gene_id baseMean baseMean_control_NC baseMean_case_VPS25siRNA foldChange log2FoldChange pval padj expression_NC_1 expression_NC_2 expression_VPS25siRNA_1 expression_VPS25siRNA_2 Dbxref product GO_id GO_term pathway pathway_description A1BG 55.7388017260041 53.8205933201931 57.657010131815 1.07128157783022 0.0993377308326319 0.889993816682608 1 1.18399 1.71321 1.18494 2.05593 GeneID:1,Genbank:NM_130786.3,HGNC:HGNC:5,MIM:138670 alpha-1-B glycoprotein A2M 67.1395063189217 52.388596733898 81.8904159039454 1.56313436528752 0.644441796125322 0.0685669772375811 0.918202374283561 0.226968 0.251292 0.375557 0.476553 GeneID:2,Genbank:NM_001347423.1,HGNC:HGNC:7,MIM:103950 alpha-2-macroglobulin hsa04610 Complement and coagulation cascades A2ML1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:144568,Genbank:NM_144670.5,HGNC:HGNC:23336,MIM:610627 alpha-2-macroglobulin like 1 GO:0004867,GO:0005615,GO:0030414,GO:0052548,GO:0070062 serine-type endopeptidase inhibitor activity|extracellular space|peptidase inhibitor activity|regulation of endopeptidase activity|extracellular exosome A3GALT2 1.21049582633443 0 2.42099165266886 Inf Inf 0.449996860143869 1 0 0 0 0.216543 GeneID:127550,Genbank:NM_001080438.1,HGNC:HGNC:30005 alpha 1,3-galactosyltransferase 2 GO:0005794,GO:0005975,GO:0006688,GO:0009247,GO:0016021,GO:0016757,GO:0030259,GO:0031982,GO:0032580,GO:0046872,GO:0047276 Golgi apparatus|carbohydrate metabolic process|glycosphingolipid biosynthetic process|glycolipid biosynthetic process|integral component of membrane|transferase activity, transferring glycosyl groups|lipid glycosylation|vesicle|Golgi cisterna membrane|metal ion binding|N-acetyllactosaminide 3-alpha-galactosyltransferase activity hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series A4GALT 260.791401234999 226.96663468774 294.616167782257 1.29805937417889 0.376356374765682 0.216635292934213 1 2.08336 2.66764 2.66045 3.62408 GeneID:53947,Genbank:NM_001318038.2,HGNC:HGNC:18149,MIM:607922 alpha 1,4-galactosyltransferase (P blood group) hsa00601,hsa00603 Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series AAAS 1116.45992535657 1143.55637212286 1089.36347859028 0.952610212444556 -0.0700420797103676 0.631945352422534 1 21.7655 22.5286 20.3342 22.4735 GeneID:8086,Genbank:NM_001173466.1,HGNC:HGNC:13666,MIM:605378 aladin WD repeat nucleoporin GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005813,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006913,GO:0007077,GO:0007612,GO:0009566,GO:0016020,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0046822,GO:0060964,GO:0075733,GO:1900034 nucleus|nuclear envelope|nuclear pore|nucleoplasm|centrosome|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nucleocytoplasmic transport|mitotic nuclear envelope disassembly|learning|fertilization|membrane|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|regulation of nucleocytoplasmic transport|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport AACS 1112.93322134962 1062.75344273054 1163.1129999687 1.09443352823239 0.130184333320426 0.393143536278194 1 11.2837 11.4306 13.1503 12.4614 GeneID:65985,Genbank:NM_023928.4,HGNC:HGNC:21298,MIM:614364 acetoacetyl-CoA synthetase GO:0001889,GO:0005524,GO:0005829,GO:0006631,GO:0007584,GO:0014074,GO:0030729,GO:0032024,GO:0034201,GO:0042594,GO:0045471,GO:0046951,GO:0047760,GO:0050872,GO:0060612,GO:0071333,GO:0071394,GO:0071397 liver development|ATP binding|cytosol|fatty acid metabolic process|response to nutrient|response to purine-containing compound|acetoacetate-CoA ligase activity|positive regulation of insulin secretion|response to oleic acid|response to starvation|response to ethanol|ketone body biosynthetic process|butyrate-CoA ligase activity|white fat cell differentiation|adipose tissue development|cellular response to glucose stimulus|cellular response to testosterone stimulus|cellular response to cholesterol hsa00280,hsa00650 Valine, leucine and isoleucine degradation|Butanoate metabolism AADACL3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0112213 0 0 0 GeneID:126767,Genbank:NM_001103170.2,HGNC:HGNC:32037 arylacetamide deacetylase like 3 GO:0009056,GO:0016787 catabolic process|hydrolase activity AADACL4 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:343066,Genbank:NM_001013630.1,HGNC:HGNC:32038 arylacetamide deacetylase like 4 GO:0009056,GO:0016021,GO:0016787,GO:0052689 catabolic process|integral component of membrane|hydrolase activity|carboxylic ester hydrolase activity AADAT 290.725784848488 296.948758616564 284.502811080412 0.958087221532308 -0.0617710940990191 0.775227478062245 1 3.10339 2.66492 3.24588 2.40381 GeneID:51166,Genbank:XM_006714231.2,HGNC:HGNC:17929,MIM:611754 aminoadipate aminotransferase GO:0005759,GO:0006103,GO:0006536,GO:0006554,GO:0006569,GO:0009058,GO:0016212,GO:0019441,GO:0030170,GO:0033512,GO:0042803,GO:0047536,GO:0070189 mitochondrial matrix|2-oxoglutarate metabolic process|glutamate metabolic process|lysine catabolic process|tryptophan catabolic process|biosynthetic process|kynurenine-oxoglutarate transaminase activity|tryptophan catabolic process to kynurenine|pyridoxal phosphate binding|L-lysine catabolic process to acetyl-CoA via saccharopine|protein homodimerization activity|2-aminoadipate transaminase activity|kynurenine metabolic process hsa00310,hsa00380 Lysine degradation|Tryptophan metabolism AAED1 222.972495278306 232.22213293947 213.722857617141 0.92033801822348 -0.119764268879297 0.599488241244114 1 8.16597 7.07994 7.69501 6.82812 GeneID:195827,Genbank:XM_005251784.4,HGNC:HGNC:16881 AhpC/TSA antioxidant enzyme domain containing 1 GO:0016209,GO:0055114 antioxidant activity|oxidation-reduction process AAGAB 1546.11599295677 1604.38682474361 1487.84516116993 0.927360620408796 -0.108797629709513 0.454776003616879 1 14.0574 13.8477 13.9835 12.3202 GeneID:79719,Genbank:NM_001271885.1,HGNC:HGNC:25662,MIM:614888 alpha and gamma adaptin binding protein GO:0005737,GO:0005829,GO:0015031,GO:0016607 cytoplasm|cytosol|protein transport|nuclear speck AAK1 744.166195964191 754.003735846566 734.328656081816 0.973905859043709 -0.038145771506664 0.883000906849388 1 1.84274 1.797 2.09452 1.44818 GeneID:22848,Genbank:NM_014911.3,HGNC:HGNC:19679,MIM:616405 AP2 associated kinase 1 GO:0004674,GO:0005112,GO:0005524,GO:0005737,GO:0005829,GO:0005905,GO:0006468,GO:0006897,GO:0019897,GO:0030136,GO:0031252,GO:0032880,GO:0035612,GO:0043195,GO:0045747,GO:0046777,GO:0050821,GO:0061024,GO:2000369 protein serine/threonine kinase activity|Notch binding|ATP binding|cytoplasm|cytosol|clathrin-coated pit|protein phosphorylation|endocytosis|extrinsic component of plasma membrane|clathrin-coated vesicle|cell leading edge|regulation of protein localization|AP-2 adaptor complex binding|terminal bouton|positive regulation of Notch signaling pathway|protein autophosphorylation|protein stabilization|membrane organization|regulation of clathrin-dependent endocytosis AAMDC 194.591566824218 168.197301073289 220.985832575148 1.31384886181293 0.393799325238681 0.0916105502152103 0.983401187832981 1.52419 2.15273 2.34223 2.38287 GeneID:28971,Genbank:NM_001316958.1,HGNC:HGNC:30205 adipogenesis associated Mth938 domain containing GO:0005737,GO:0043066,GO:0045600,GO:0045944 cytoplasm|negative regulation of apoptotic process|positive regulation of fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter AAMP 2482.54854017071 2517.46083547161 2447.6362448698 0.972263882075953 -0.0405801661441487 0.796913043108202 1 31.0298 32.3069 29.2725 32.7434 GeneID:14,Genbank:XM_024452712.1,HGNC:HGNC:18,MIM:603488 angio associated migratory cell protein AANAT 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0 GeneID:15,Genbank:NM_001166579.1,HGNC:HGNC:19,MIM:600950 aralkylamine N-acetyltransferase hsa00380 Tryptophan metabolism AAR2 1313.43203930661 1267.98444794363 1358.87963066959 1.07168477726471 0.0998806174067587 0.511330612133886 1 14.2823 15.43 16.396 15.994 GeneID:25980,Genbank:XM_006723770.3,HGNC:HGNC:15886,MIM:617365 AAR2 splicing factor homolog GO:0000244,GO:0005681 spliceosomal tri-snRNP complex assembly|spliceosomal complex AARS 7295.88748983121 6740.0612907362 7851.71368892622 1.16493209041258 0.220245855582899 0.223568905335888 1 60.1004 62.7735 66.5216 77.7343 GeneID:16,Genbank:NM_001605.2,HGNC:HGNC:20,MIM:601065 alanyl-tRNA synthetase GO:0000049,GO:0002161,GO:0004813,GO:0005524,GO:0005737,GO:0005829,GO:0006400,GO:0006418,GO:0006419,GO:0008033,GO:0016020,GO:0016597,GO:0021680,GO:0043524,GO:0046872,GO:0050885,GO:0070062 tRNA binding|aminoacyl-tRNA editing activity|alanine-tRNA ligase activity|ATP binding|cytoplasm|cytosol|tRNA modification|tRNA aminoacylation for protein translation|alanyl-tRNA aminoacylation|tRNA processing|membrane|amino acid binding|cerebellar Purkinje cell layer development|negative regulation of neuron apoptotic process|metal ion binding|neuromuscular process controlling balance|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis AARS2 948.028121477691 912.227121092184 983.829121863199 1.07849141854639 0.109014697156854 0.482788934687667 1 5.80847 5.51429 6.50037 5.85335 GeneID:57505,Genbank:XM_011514764.2,HGNC:HGNC:21022,MIM:612035 alanyl-tRNA synthetase 2, mitochondrial GO:0000049,GO:0004813,GO:0005524,GO:0005739,GO:0006400,GO:0016597,GO:0033108,GO:0046872,GO:0070143 tRNA binding|alanine-tRNA ligase activity|ATP binding|mitochondrion|tRNA modification|amino acid binding|mitochondrial respiratory chain complex assembly|metal ion binding|mitochondrial alanyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis AASDH 190.497810460177 231.232181480447 149.763439439907 0.647675589448913 -0.626656724195699 0.00747901418889063 0.341216961574625 1.17532 1.04233 0.810104 0.653279 GeneID:132949,Genbank:XM_017007743.2,HGNC:HGNC:23993,MIM:614365 aminoadipate-semialdehyde dehydrogenase GO:0005524,GO:0006631,GO:0016878,GO:0019482,GO:0043041 ATP binding|fatty acid metabolic process|acid-thiol ligase activity|beta-alanine metabolic process|amino acid activation for nonribosomal peptide biosynthetic process AASDHPPT 429.828058910412 494.712005939855 364.944111880969 0.737690024699618 -0.438913367723053 0.0401125289069181 0.758464027333929 5.50475 4.59 3.94509 3.21743 GeneID:60496,Genbank:NM_015423.2,HGNC:HGNC:14235,MIM:607756 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase GO:0000287,GO:0005829,GO:0008897,GO:0015939,GO:0019878,GO:0070062 magnesium ion binding|cytosol|holo-[acyl-carrier-protein] synthase activity|pantothenate metabolic process|lysine biosynthetic process via aminoadipic acid|extracellular exosome hsa00770 Pantothenate and CoA biosynthesis AASS 356.014729999548 376.136377978099 335.893082020996 0.893008764072679 -0.163253760725469 0.572282232197502 1 2.26171 2.00634 2.28081 1.52188 GeneID:10157,Genbank:NM_005763.3,HGNC:HGNC:17366,MIM:605113 aminoadipate-semialdehyde synthase GO:0004753,GO:0005739,GO:0005759,GO:0006091,GO:0006554,GO:0019878,GO:0033512,GO:0043231,GO:0047130,GO:0047131,GO:0051262 saccharopine dehydrogenase activity|mitochondrion|mitochondrial matrix|generation of precursor metabolites and energy|lysine catabolic process|lysine biosynthetic process via aminoadipic acid|L-lysine catabolic process to acetyl-CoA via saccharopine|intracellular membrane-bounded organelle|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|protein tetramerization hsa00310 Lysine degradation AATF 2512.6191726945 2651.51480054045 2373.72354484855 0.895232998271298 -0.159664879881185 0.2517376697617 1 35.5189 34.1449 32.593 30.8541 GeneID:26574,Genbank:NM_012138.3,HGNC:HGNC:19235,MIM:608463 apoptosis antagonizing transcription factor AATK 2.80501721271076 3.67063118712625 1.93940323829528 0.528356879083145 -0.920415366515017 0.715156042730903 1 0.029227 0.0122482 0.0133654 0.00626924 GeneID:9625,Genbank:NM_001080395.2,HGNC:HGNC:21,MIM:605276 apoptosis associated tyrosine kinase GO:0004674,GO:0005524,GO:0016021,GO:0048471 protein serine/threonine kinase activity|ATP binding|integral component of membrane|perinuclear region of cytoplasm ABAT 8.24247742901292 5.82302189369546 10.6619329643304 1.83099654422972 0.87262906823664 0.390519005566807 1 0.0685286 0.0139182 0.079193 0.0671483 GeneID:18,Genbank:NM_020686.5,HGNC:HGNC:23,MIM:137150 4-aminobutyrate aminotransferase hsa00250,hsa00280,hsa00410,hsa00640,hsa00650,hsa04727 Alanine, aspartate and glutamate metabolism|Valine, leucine and isoleucine degradation|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism|GABAergic synapse ABCA1 459.640270945278 472.851914951369 446.428626939187 0.944119316900938 -0.0829588973516147 0.798812620629638 1 1.24563 1.08203 1.44173 0.858158 GeneID:19,Genbank:NM_005502.3,HGNC:HGNC:29,MIM:600046 ATP binding cassette subfamily A member 1 hsa02010,hsa04975,hsa04979 ABC transporters|Fat digestion and absorption|Cholesterol metabolism ABCA10 3.79873196920088 3.71865746181119 3.87880647659057 1.04306635295776 0.0608309354591044 1 1 0.0382976 0.00628687 0.0186506 0.0115412 GeneID:10349,Genbank:NM_080282.3,HGNC:HGNC:30,MIM:612508 ATP binding cassette subfamily A member 10 hsa02010 ABC transporters ABCA12 20.0033733539188 21.591550650593 18.4151960572445 0.852889000667433 -0.229570100831236 0.753729445328787 1 0.0602593 0.0725129 0.0616251 0.0644393 GeneID:26154,Genbank:XM_011510951.2,HGNC:HGNC:14637,MIM:607800 ATP binding cassette subfamily A member 12 hsa02010 ABC transporters ABCA13 31.306222088592 27.2224674455487 35.3899767316353 1.30002825065081 0.37854297450833 0.56091171964682 1 0.0328431 0.0327032 0.0574234 0.0200436 GeneID:154664,Genbank:XM_017011769.1,HGNC:HGNC:14638,MIM:607807 ATP binding cassette subfamily A member 13 hsa02010 ABC transporters ABCA2 1131.70749228472 1092.07148295372 1171.34350161573 1.07258867198656 0.101096921708246 0.519546224660685 1 5.25379 5.35957 5.82555 5.67459 GeneID:20,Genbank:NM_212533.2,HGNC:HGNC:32,MIM:600047 ATP binding cassette subfamily A member 2 hsa02010,hsa04142 ABC transporters|Lysosome ABCA3 1636.90202965452 1612.48974986027 1661.31430944876 1.03027898911774 0.043035057520879 0.792318390626033 1 8.94317 10.0036 10.4026 9.80745 GeneID:21,Genbank:NM_001089.2,HGNC:HGNC:33,MIM:601615 ATP binding cassette subfamily A member 3 hsa02010 ABC transporters ABCA4 1.93972985784689 0.490071401957362 3.38938831373641 6.91611120379413 2.78996106618559 0.521778945460786 1 0 0.00460773 0 0.0312797 GeneID:24,Genbank:NM_000350.2,HGNC:HGNC:34,MIM:601691 ATP binding cassette subfamily A member 4 hsa02010 ABC transporters ABCA5 19.0574441181834 17.2769605823466 20.8379276540202 1.20611073659056 0.270362371413657 0.674214122836061 1 0.0951917 0.0366826 0.0774109 0.0910945 GeneID:23461,Genbank:NM_172232.3,HGNC:HGNC:35,MIM:612503 ATP binding cassette subfamily A member 5 hsa02010 ABC transporters ABCA6 1.48084962273568 0.538097676642304 2.42360156882906 4.50401790238564 2.17121256179462 0.55094696455999 1 0.00513894 0 0.014927 0.00926631 GeneID:23460,Genbank:XM_017024404.2,HGNC:HGNC:36,MIM:612504 ATP binding cassette subfamily A member 6 hsa02010 ABC transporters ABCA7 1092.44968624864 984.113729700753 1200.78564279652 1.22016958666114 0.287081676338927 0.201244096661062 1 5.53612 5.84963 6.61138 8.11238 GeneID:10347,Genbank:NM_019112.3,HGNC:HGNC:37,MIM:605414 ATP binding cassette subfamily A member 7 hsa02010 ABC transporters ABCA8 19.57089943936 22.6677460038776 16.4740528748424 0.726761843547406 -0.460445417706608 0.498011968581926 1 0.116108 0.117713 0.0592128 0.0916373 GeneID:10351,Genbank:XM_005256940.4,HGNC:HGNC:38,MIM:612505 ATP binding cassette subfamily A member 8 hsa02010 ABC transporters ABCA9 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0051537 0 0 GeneID:10350,Genbank:XM_017024011.1,HGNC:HGNC:39,MIM:612507 ATP binding cassette subfamily A member 9 hsa02010 ABC transporters ABCB1 2.02732192048667 3.084507235799 0.97013660517434 0.314519153631695 -1.66878021766181 0.551855804198651 1 0 0.0238605 0.0161109 0 GeneID:5243,Genbank:NM_001348944.1,HGNC:HGNC:40,MIM:171050 ATP binding cassette subfamily B member 1 hsa02010,hsa04976,hsa05206,hsa05226 ABC transporters|Bile secretion|MicroRNAs in cancer|Gastric cancer ABCB10 464.227936132813 485.449692578205 443.006179687421 0.912568668721638 -0.131994972394462 0.487983483610283 1 4.55915 4.40218 5.08024 3.52481 GeneID:23456,Genbank:NM_012089.2,HGNC:HGNC:41,MIM:605454 ATP binding cassette subfamily B member 10 hsa02010 ABC transporters ABCB11 9.70018388645952 6.31309329565283 13.0872744772662 2.07303676096124 1.05174569984638 0.257560916268612 1 0.0602029 0.0190021 0.0833351 0.0416101 GeneID:8647,Genbank:XM_017005165.1,HGNC:HGNC:42,MIM:603201 ATP binding cassette subfamily B member 11 hsa01522,hsa02010,hsa04976,hsa04979 Endocrine resistance|ABC transporters|Bile secretion|Cholesterol metabolism ABCB4 157.363590103307 171.281808309088 143.445371897526 0.837481652684741 -0.255870510245327 0.297299334301115 1 0.616892 0.713354 0.58737 0.555547 GeneID:5244,Genbank:XM_011516310.3,HGNC:HGNC:45,MIM:171060 ATP binding cassette subfamily B member 4 hsa02010,hsa04976 ABC transporters|Bile secretion ABCB5 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0108258 0.00541134 0 GeneID:340273,Genbank:NM_001163941.1,HGNC:HGNC:46,MIM:611785 ATP binding cassette subfamily B member 5 hsa02010 ABC transporters ABCB6 872.656150903925 892.903631007746 852.408670800105 0.954648005897414 -0.0669592086033256 0.661690748813941 1 12.3511 12.2371 11.4476 13.0001 GeneID:10058,Genbank:NM_001349828.1,HGNC:HGNC:47,MIM:605452 ATP binding cassette subfamily B member 6 (Langereis blood group) hsa02010 ABC transporters ABCB7 606.923656631041 633.775597235306 580.071716026775 0.915263570508551 -0.127740835524167 0.444738281071105 1 8.51216 9.23699 8.00597 8.40427 GeneID:22,Genbank:NM_001271698.2,HGNC:HGNC:48,MIM:300135 ATP binding cassette subfamily B member 7 hsa02010 ABC transporters ABCB8 975.439930126405 938.0284176074 1012.85144264541 1.07976626681403 0.110719051090107 0.488910600726161 1 6.59386 6.91875 7.42284 7.65591 GeneID:11194,Genbank:NM_001282291.1,HGNC:HGNC:49,MIM:605464 ATP binding cassette subfamily B member 8 hsa02010 ABC transporters ABCB9 466.544211276547 463.973811787198 469.114610765896 1.01107993349645 0.0158970576765038 0.938700494553391 1 2.01574 2.0988 2.12498 2.30982 GeneID:23457,Genbank:NM_001243014.1,HGNC:HGNC:50,MIM:605453 ATP binding cassette subfamily B member 9 hsa02010,hsa04142 ABC transporters|Lysosome ABCC1 2496.70988405932 2557.68490805169 2435.73486006695 0.952320144048692 -0.0704814451055809 0.598759237879539 1 12.2987 12.7396 12.3451 11.8569 GeneID:4363,Genbank:NM_004996.3,HGNC:HGNC:51,MIM:158343 ATP binding cassette subfamily C member 1 hsa01523,hsa02010,hsa04071,hsa04977,hsa05206 Antifolate resistance|ABC transporters|Sphingolipid signaling pathway|Vitamin digestion and absorption|MicroRNAs in cancer ABCC10 635.457771637147 656.933414641141 613.982128633154 0.934618509196324 -0.0975504862515968 0.557093908255653 1 3.57449 3.52809 3.23397 3.64386 GeneID:89845,Genbank:XM_017011446.2,HGNC:HGNC:52,MIM:612509 ATP binding cassette subfamily C member 10 hsa02010 ABC transporters ABCC11 2.70222161986389 2.49838328447175 2.90605995525603 1.16317619210716 0.218069645587095 1 1 0.00443873 0.0123574 0.0042252 0.0118086 GeneID:85320,Genbank:XM_017023801.2,HGNC:HGNC:14639,MIM:607040 ATP binding cassette subfamily C member 11 hsa02010 ABC transporters ABCC12 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:94160,Genbank:NM_033226.2,HGNC:HGNC:14640,MIM:607041 ATP binding cassette subfamily C member 12 hsa02010 ABC transporters ABCC2 358.675845236363 332.540657514965 384.811032957762 1.15718491637506 0.21061942332249 0.2624585339447 1 1.38879 1.38401 1.77518 1.53475 GeneID:1244,Genbank:NM_000392.4,HGNC:HGNC:53,MIM:601107 ATP binding cassette subfamily C member 2 hsa01523,hsa01524,hsa02010,hsa04976 Antifolate resistance|Platinum drug resistance|ABC transporters|Bile secretion ABCC3 4240.47420989702 3889.53150872809 4591.41691106596 1.18045499843949 0.239343043882794 0.0771515157948794 0.94157495521624 22.1206 22.9557 28.5116 26.6952 GeneID:8714,Genbank:XM_011525423.1,HGNC:HGNC:54,MIM:604323 ATP binding cassette subfamily C member 3 hsa01523,hsa02010,hsa04976 Antifolate resistance|ABC transporters|Bile secretion ABCC4 431.280123115758 479.674696959195 382.885549272321 0.798219192505984 -0.325143127237973 0.0736548003265264 0.934750619674839 2.02778 1.92671 1.72788 1.42255 GeneID:10257,Genbank:NM_001301829.1,HGNC:HGNC:55,MIM:605250 ATP binding cassette subfamily C member 4 hsa01523,hsa02010,hsa04024,hsa04976 Antifolate resistance|ABC transporters|cAMP signaling pathway|Bile secretion ABCC5 1065.99819399552 1126.85470983587 1005.14167815517 0.891988709264537 -0.164902646166842 0.279449592488806 1 3.56754 3.47565 3.28251 3.04504 GeneID:10057,Genbank:NM_005688.3,HGNC:HGNC:56,MIM:605251 ATP binding cassette subfamily C member 5 hsa01523,hsa02010 Antifolate resistance|ABC transporters ABCC6 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00632971 GeneID:368,Genbank:XM_024450261.1,HGNC:HGNC:57,MIM:603234 ATP binding cassette subfamily C member 6 hsa02010 ABC transporters ABCC9 2.02144884906308 2.10436443188427 1.93853326624189 0.921196555534869 -0.118419078157443 1 1 0.00906942 0 0.00438242 0.00813282 GeneID:10060,Genbank:XM_005253290.4,HGNC:HGNC:60,MIM:601439 ATP binding cassette subfamily C member 9 hsa02010 ABC transporters ABCD1 660.109033461506 630.124583358396 690.093483564616 1.09516991050659 0.13115471460175 0.437312084480051 1 7.46752 7.32031 8.27373 8.3172 GeneID:215,Genbank:NM_000033.3,HGNC:HGNC:61,MIM:300371 ATP binding cassette subfamily D member 1 hsa02010,hsa04146 ABC transporters|Peroxisome ABCD2 1.48672269415927 1.51824048055703 1.45520490776151 0.958481167112346 -0.0611780097655067 1 1 0.0026169 0.00514579 0.00762458 0 GeneID:225,Genbank:XM_017018992.2,HGNC:HGNC:66,MIM:601081 ATP binding cassette subfamily D member 2 hsa02010,hsa04146 ABC transporters|Peroxisome ABCD3 684.510200896055 703.055927353216 665.964474438894 0.947242528693328 -0.0781942392608924 0.73498685092643 1 6.18941 5.67015 6.72458 4.86655 GeneID:5825,Genbank:XM_006710802.2,HGNC:HGNC:67,MIM:170995 ATP binding cassette subfamily D member 3 hsa02010,hsa04146 ABC transporters|Peroxisome ABCD4 458.248221174209 444.00636282164 472.490079526778 1.06415159576571 0.08970368738097 0.628062371686374 1 3.49805 3.67976 3.79936 3.96509 GeneID:5826,Genbank:NM_001353607.1,HGNC:HGNC:68,MIM:603214 ATP binding cassette subfamily D member 4 hsa02010,hsa04146 ABC transporters|Peroxisome ABCE1 1077.32763904688 1247.35037178417 907.304906309581 0.727385766528293 -0.459207399448459 0.0263191396754605 0.649502836736788 12.5801 11.247 9.84843 7.66739 GeneID:6059,Genbank:NM_002940.2,HGNC:HGNC:69,MIM:601213 ATP binding cassette subfamily E member 1 ABCF1 4447.49194860567 4505.19880505202 4389.78509215931 0.974382104345031 -0.0374404581638111 0.788286536194588 1 37.8669 36.0727 37.6261 35.2215 GeneID:23,Genbank:NM_001025091.1,HGNC:HGNC:70,MIM:603429 ATP binding cassette subfamily F member 1 GO:0005524,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0006413,GO:0008494,GO:0016887,GO:0042788,GO:0043022,GO:0045727 ATP binding|nuclear envelope|nucleoplasm|cytoplasm|cytosol|translational initiation|translation activator activity|ATPase activity|polysomal ribosome|ribosome binding|positive regulation of translation ABCF2 4497.16969586226 4788.81587661639 4205.52351510814 0.878196953790508 -0.187383564703196 0.153894887690671 1 27.6646 29.3581 25.7816 25.6915 GeneID:10061,Genbank:NM_005692.4,HGNC:HGNC:71,MIM:612510 ATP binding cassette subfamily F member 2 ABCF3 2185.72183846269 2111.63201572796 2259.81166119742 1.0701730435823 0.0978440946948523 0.495833597206839 1 21.1277 21.5807 24.4297 22.3383 GeneID:55324,Genbank:NM_001351300.1,HGNC:HGNC:72 ATP binding cassette subfamily F member 3 GO:0005524,GO:0016020,GO:0016887,GO:0045296,GO:0051607 ATP binding|membrane|ATPase activity|cadherin binding|defense response to virus ABCG1 1.02816907859967 2.05633815719933 0 0 -Inf 0.409782672813165 1 0.00805799 0.0073158 0 0 GeneID:9619,Genbank:NM_207627.1,HGNC:HGNC:73,MIM:603076 ATP binding cassette subfamily G member 1 hsa02010 ABC transporters ABCG2 18.9087113151637 19.8812050712962 17.9362175590311 0.902169536238365 -0.148529523815534 0.846879270911226 1 0.098192 0.117482 0.165421 0.0660255 GeneID:9429,Genbank:NM_001257386.2,HGNC:HGNC:74,MIM:603756 ATP binding cassette subfamily G member 2 (Junior blood group) hsa01523,hsa02010,hsa04976 Antifolate resistance|ABC transporters|Bile secretion ABCG4 5.31273095596601 6.26506702096788 4.36039489096415 0.695985354405756 -0.52287114707269 0.76298086435093 1 0.0707786 0.00886525 0.00943666 0.0352327 GeneID:64137,Genbank:NM_022169.4,HGNC:HGNC:13884,MIM:607784 ATP binding cassette subfamily G member 4 hsa02010 ABC transporters ABHD1 23.9369860758461 32.8533842405044 15.0205879111877 0.457200628137088 -1.12910070924914 0.0537727003251427 0.845995646765703 0.535035 0.347597 0.228017 0.27663 GeneID:84696,Genbank:XM_024453180.1,HGNC:HGNC:17553,MIM:612195 abhydrolase domain containing 1 GO:0016021,GO:0016298,GO:0044255,GO:0052689 integral component of membrane|lipase activity|cellular lipid metabolic process|carboxylic ester hydrolase activity ABHD10 428.449659356909 450.280221496861 406.619097216956 0.903035660472133 -0.147145134677933 0.43419805726511 1 7.7751 6.94376 7.13939 6.19329 GeneID:55347,Genbank:NM_001272069.1,HGNC:HGNC:25656 abhydrolase domain containing 10 GO:0004553,GO:0005739,GO:0005759,GO:0005829,GO:0019391,GO:0052695,GO:0102390 hydrolase activity, hydrolyzing O-glycosyl compounds|mitochondrion|mitochondrial matrix|cytosol|glucuronoside catabolic process|cellular glucuronidation|mycophenolic acid acyl-glucuronide esterase activity ABHD11 704.522091559473 724.322119736977 684.722063381968 0.945328114003492 -0.0811129335055742 0.611337500828845 1 7.99823 8.1102 7.08383 8.87892 GeneID:83451,Genbank:NM_148913.3,HGNC:HGNC:16407 abhydrolase domain containing 11 GO:0005739,GO:0016787 mitochondrion|hydrolase activity ABHD12 1655.06255640002 1556.7078539314 1753.41725886864 1.12636244137939 0.171671133140495 0.236582874672842 1 12.7366 13.195 16.6269 14.4206 GeneID:26090,Genbank:NM_015600.4,HGNC:HGNC:15868,MIM:613599 abhydrolase domain containing 12 GO:0002084,GO:0004622,GO:0005886,GO:0006660,GO:0007628,GO:0008474,GO:0010996,GO:0016021,GO:0032281,GO:0032839,GO:0046464,GO:0046475,GO:0047372,GO:0052651 protein depalmitoylation|lysophospholipase activity|plasma membrane|phosphatidylserine catabolic process|adult walking behavior|palmitoyl-(protein) hydrolase activity|response to auditory stimulus|integral component of membrane|AMPA glutamate receptor complex|dendrite cytoplasm|acylglycerol catabolic process|glycerophospholipid catabolic process|acylglycerol lipase activity|monoacylglycerol catabolic process ABHD13 220.631809292298 234.326497371354 206.937121213241 0.883114472902708 -0.179327636872154 0.426988615785391 1 1.51929 1.56736 1.44314 1.39472 GeneID:84945,Genbank:NM_032859.2,HGNC:HGNC:20293 abhydrolase domain containing 13 GO:0002084,GO:0008474,GO:0016020,GO:0016021,GO:0032839 protein depalmitoylation|palmitoyl-(protein) hydrolase activity|membrane|integral component of membrane|dendrite cytoplasm ABHD14A 101.295144296433 96.4655969447368 106.124691648129 1.10012994279117 0.137673938975862 0.671961949440995 1 7.21911 8.29745 9.08886 11.2156 GeneID:25864,Genbank:NM_015407.4,HGNC:HGNC:24538 abhydrolase domain containing 14A GO:0005737,GO:0016021,GO:0016787,GO:0070062 cytoplasm|integral component of membrane|hydrolase activity|extracellular exosome ABHD14B 609.348651795668 523.780106134503 694.917197456833 1.32673461499965 0.407879819152837 0.0138686653270936 0.483922753548435 10.4993 9.42047 13.0497 14.4421 GeneID:84836,Genbank:NM_001254753.1,HGNC:HGNC:28235 abhydrolase domain containing 14B GO:0005634,GO:0005730,GO:0005829,GO:0016787,GO:0045944,GO:0050427,GO:0070062 nucleus|nucleolus|cytosol|hydrolase activity|positive regulation of transcription from RNA polymerase II promoter|3'-phosphoadenosine 5'-phosphosulfate metabolic process|extracellular exosome ABHD15 713.88337136802 704.171357326933 723.595385409107 1.02758423483157 0.0392566617344175 0.808736317898064 1 9.87449 9.56901 11.1279 9.13116 GeneID:116236,Genbank:NM_198147.2,HGNC:HGNC:26971 abhydrolase domain containing 15 GO:0005576,GO:0016020,GO:0016788,GO:0044255 extracellular region|membrane|hydrolase activity, acting on ester bonds|cellular lipid metabolic process ABHD16A 929.744822573061 905.789566282692 953.70007886343 1.05289364590206 0.0743597153011221 0.644535008677973 1 12.7311 13.4506 13.8235 14.0537 GeneID:7920,Genbank:NM_021160.2,HGNC:HGNC:13921,MIM:142620 abhydrolase domain containing 16A GO:0016021,GO:0047372,GO:0052651,GO:1905344 integral component of membrane|acylglycerol lipase activity|monoacylglycerol catabolic process|prostaglandin catabolic process ABHD16B 4.50601942702926 4.65077399104097 4.36126486301754 0.93775033390547 -0.092724223299013 1 1 0.102638 0.167125 0.139082 0.215934 GeneID:140701,Genbank:NM_080622.3,HGNC:HGNC:16128 abhydrolase domain containing 16B GO:0016787 hydrolase activity ABHD17A 1408.63865157447 1396.91144427799 1420.36585887095 1.01679019431692 0.0240220225143529 0.942180278004957 1 9.46242 11.349 10.7129 11.4238 GeneID:81926,Genbank:NM_001130111.1,HGNC:HGNC:28756 abhydrolase domain containing 17A GO:0002084,GO:0005576,GO:0005886,GO:0008474,GO:0010008,GO:0014069,GO:0016020,GO:0018345,GO:0055038,GO:0072657,GO:1902817,GO:1905668 protein depalmitoylation|extracellular region|plasma membrane|palmitoyl-(protein) hydrolase activity|endosome membrane|postsynaptic density|membrane|protein palmitoylation|recycling endosome membrane|protein localization to membrane|negative regulation of protein localization to microtubule|positive regulation of protein localization to endosome hsa00062 Fatty acid elongation ABHD17B 332.7748585669 364.597212396041 300.952504737759 0.825438304259035 -0.27676770708477 0.147151708268203 1 3.60877 4.25216 3.39878 3.36097 GeneID:51104,Genbank:NM_016014.3,HGNC:HGNC:24278 abhydrolase domain containing 17B GO:0002084,GO:0005576,GO:0005886,GO:0008474,GO:0014069,GO:0016020,GO:0018345,GO:0055038,GO:1902473,GO:1902817,GO:1902950,GO:1905668 protein depalmitoylation|extracellular region|plasma membrane|palmitoyl-(protein) hydrolase activity|postsynaptic density|membrane|protein palmitoylation|recycling endosome membrane|regulation of protein localization to synapse|negative regulation of protein localization to microtubule|regulation of dendritic spine maintenance|positive regulation of protein localization to endosome hsa00062 Fatty acid elongation ABHD17C 402.67885418978 429.794292164876 375.563416214683 0.873821321178949 -0.194589787017956 0.291455182419384 1 11.066 11.5161 9.43072 10.4117 GeneID:58489,Genbank:NM_021214.1,HGNC:HGNC:26925 abhydrolase domain containing 17C GO:0002084,GO:0008474,GO:0014069,GO:0018345,GO:1902817,GO:1905668 protein depalmitoylation|palmitoyl-(protein) hydrolase activity|postsynaptic density|protein palmitoylation|negative regulation of protein localization to microtubule|positive regulation of protein localization to endosome hsa00062 Fatty acid elongation ABHD18 140.884549451902 152.36112873149 129.407970172313 0.849350298529043 -0.235568405984939 0.378514782583857 1 0.568261 0.569289 0.523786 0.455019 GeneID:80167,Genbank:NM_001358454.1,HGNC:HGNC:26111 abhydrolase domain containing 18 GO:0005576 extracellular region ABHD2 4354.42560900719 4716.50073818563 3992.35047982874 0.846464508635811 -0.240478516179964 0.158317812204218 1 22.5847 21.1855 21.6071 15.8849 GeneID:11057,Genbank:NM_007011.7,HGNC:HGNC:18717,MIM:612196 abhydrolase domain containing 2 GO:0001669,GO:0003707,GO:0007340,GO:0009611,GO:0016021,GO:0030336,GO:0032570,GO:0036126,GO:0042562,GO:0043401,GO:0046464,GO:0047372,GO:0048240,GO:0097524 acrosomal vesicle|steroid hormone receptor activity|acrosome reaction|response to wounding|integral component of membrane|negative regulation of cell migration|response to progesterone|sperm flagellum|hormone binding|steroid hormone mediated signaling pathway|acylglycerol catabolic process|acylglycerol lipase activity|sperm capacitation|sperm plasma membrane ABHD3 429.470713076904 453.240267218821 405.701158934986 0.895112787362109 -0.159858616403146 0.509773694720846 1 4.74452 4.88366 5.73001 3.57364 GeneID:171586,Genbank:NM_001308256.1,HGNC:HGNC:18718,MIM:612197 abhydrolase domain containing 3 GO:0004623,GO:0005886,GO:0006656,GO:0008970,GO:0016021,GO:0046470,GO:0052739,GO:0052740,GO:0102567,GO:0102568 phospholipase A2 activity|plasma membrane|phosphatidylcholine biosynthetic process|phosphatidylcholine 1-acylhydrolase activity|integral component of membrane|phosphatidylcholine metabolic process|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) ABHD4 1023.91587734081 985.102664158921 1062.72909052271 1.07880034151574 0.109427883400082 0.48113422652208 1 11.1656 11.4673 11.8535 13.0189 GeneID:63874,Genbank:NM_022060.2,HGNC:HGNC:20154 abhydrolase domain containing 4 GO:0005789,GO:0016042,GO:0016787,GO:0036152 endoplasmic reticulum membrane|lipid catabolic process|hydrolase activity|phosphatidylethanolamine acyl-chain remodeling ABHD5 556.729245632912 588.602784360967 524.855706904857 0.891697628434907 -0.165373514687003 0.342045464093106 1 3.71017 3.53677 3.37211 3.06473 GeneID:51099,Genbank:NM_001355186.1,HGNC:HGNC:21396,MIM:604780 abhydrolase domain containing 5 GO:0003841,GO:0005811,GO:0005829,GO:0006631,GO:0006654,GO:0010891,GO:0010898,GO:0030154,GO:0042171,GO:0051006 1-acylglycerol-3-phosphate O-acyltransferase activity|lipid droplet|cytosol|fatty acid metabolic process|phosphatidic acid biosynthetic process|negative regulation of sequestering of triglyceride|positive regulation of triglyceride catabolic process|cell differentiation|lysophosphatidic acid acyltransferase activity|positive regulation of lipoprotein lipase activity hsa04923 Regulation of lipolysis in adipocytes ABHD6 532.327306019002 573.277317732196 491.377294305808 0.857137163998791 -0.222402003750768 0.190090369466804 1 8.52001 9.27046 7.02202 8.09965 GeneID:57406,Genbank:NM_001320126.1,HGNC:HGNC:21398,MIM:616966 abhydrolase domain containing 6 GO:0004620,GO:0005739,GO:0005886,GO:0009395,GO:0016021,GO:0030336,GO:0032281,GO:0046464,GO:0046889,GO:0047372,GO:0060292,GO:0070062,GO:2000124 phospholipase activity|mitochondrion|plasma membrane|phospholipid catabolic process|integral component of membrane|negative regulation of cell migration|AMPA glutamate receptor complex|acylglycerol catabolic process|positive regulation of lipid biosynthetic process|acylglycerol lipase activity|long term synaptic depression|extracellular exosome|regulation of endocannabinoid signaling pathway hsa04723 Retrograde endocannabinoid signaling ABHD8 750.698603514956 732.336766957674 769.060440072238 1.05014588201972 0.0705897551746144 0.687328184096209 1 19.3652 20.8456 21.082 22.6085 GeneID:79575,Genbank:NM_024527.4,HGNC:HGNC:23759 abhydrolase domain containing 8 GO:0016787,GO:0070062 hydrolase activity|extracellular exosome ABI1 828.64120308172 849.892000494229 807.390405669212 0.949991769777452 -0.0740130801308178 0.660730252541532 1 5.18468 4.86058 4.95093 4.76512 GeneID:10006,Genbank:NM_001178125.1,HGNC:HGNC:11320,MIM:603050 abl interactor 1 GO:0001756,GO:0005622,GO:0005634,GO:0005856,GO:0008154,GO:0014069,GO:0017124,GO:0018108,GO:0030027,GO:0030054,GO:0030175,GO:0030296,GO:0030426,GO:0031209,GO:0031252,GO:0032403,GO:0035855,GO:0043005,GO:0045211,GO:0045296,GO:0048813,GO:0072673 somitogenesis|intracellular|nucleus|cytoskeleton|actin polymerization or depolymerization|postsynaptic density|SH3 domain binding|peptidyl-tyrosine phosphorylation|lamellipodium|cell junction|filopodium|protein tyrosine kinase activator activity|growth cone|SCAR complex|cell leading edge|protein complex binding|megakaryocyte development|neuron projection|postsynaptic membrane|cadherin binding|dendrite morphogenesis|lamellipodium morphogenesis ABI2 1892.9109503672 1923.30255255399 1862.5193481804 0.96839644168679 -0.0463303166350375 0.742911203550886 1 9.04034 9.24301 9.28198 7.77157 GeneID:10152,Genbank:XM_024452511.1,HGNC:HGNC:24011,MIM:606442 abl interactor 2 GO:0003677,GO:0005737,GO:0005829,GO:0005856,GO:0006928,GO:0007010,GO:0008093,GO:0008154,GO:0016032,GO:0016477,GO:0016601,GO:0017124,GO:0018108,GO:0019900,GO:0030027,GO:0030175,GO:0031209,GO:0031625,GO:0032403,GO:0070064,GO:2000601 DNA binding|cytoplasm|cytosol|cytoskeleton|movement of cell or subcellular component|cytoskeleton organization|cytoskeletal adaptor activity|actin polymerization or depolymerization|viral process|cell migration|Rac protein signal transduction|SH3 domain binding|peptidyl-tyrosine phosphorylation|kinase binding|lamellipodium|filopodium|SCAR complex|ubiquitin protein ligase binding|protein complex binding|proline-rich region binding|positive regulation of Arp2/3 complex-mediated actin nucleation hsa04810 Regulation of actin cytoskeleton ABI3 1.27026824386655 2.05633815719933 0.484198330533773 0.235466296649008 -2.08640751970762 0.631842364882622 1 0.042267 0.0182989 0 0 GeneID:51225,Genbank:NM_016428.2,HGNC:HGNC:29859,MIM:606363 ABI family member 3 GO:0005622,GO:0005737,GO:0006928,GO:0016020,GO:0030027,GO:0030334,GO:0042802 intracellular|cytoplasm|movement of cell or subcellular component|membrane|lamellipodium|regulation of cell migration|identical protein binding ABI3BP 549.506314932031 542.075427140341 556.937202723722 1.02741643476035 0.0390210566227128 0.88543290491547 1 1.76015 1.40971 2.14138 1.35253 GeneID:25890,Genbank:XM_024453445.1,HGNC:HGNC:17265,MIM:606279 ABI family member 3 binding protein GO:0005518,GO:0005576,GO:0005614,GO:0005615,GO:0008201,GO:0010811,GO:0030198,GO:0031012 collagen binding|extracellular region|interstitial matrix|extracellular space|heparin binding|positive regulation of cell-substrate adhesion|extracellular matrix organization|extracellular matrix ABL1 2369.2918303565 2198.16191446461 2540.42174624839 1.15570273942588 0.208770367125015 0.137805343407735 1 13.3834 14.2232 16.5362 15.9322 GeneID:25,Genbank:NM_007313.2,HGNC:HGNC:76,MIM:189980 ABL proto-oncogene 1, non-receptor tyrosine kinase hsa04012,hsa04014,hsa04110,hsa04360,hsa04722,hsa05130,hsa05131,hsa05200,hsa05206,hsa05220,hsa05416 ErbB signaling pathway|Ras signaling pathway|Cell cycle|Axon guidance|Neurotrophin signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Pathways in cancer|MicroRNAs in cancer|Chronic myeloid leukemia|Viral myocarditis ABL2 2197.47170570294 2066.83157039429 2328.1118410116 1.12641585040598 0.171739540172019 0.578511338612377 1 5.14451 5.03127 7.2466 4.44848 GeneID:27,Genbank:NM_001168238.1,HGNC:HGNC:77,MIM:164690 ABL proto-oncogene 2, non-receptor tyrosine kinase hsa04012,hsa04014,hsa05416 ErbB signaling pathway|Ras signaling pathway|Viral myocarditis ABLIM1 924.583038952912 882.754176388986 966.411901516837 1.09476899386652 0.130626480271789 0.443260058048578 1 2.71097 2.25148 3.07944 2.52602 GeneID:3983,Genbank:NM_001322885.2,HGNC:HGNC:78,MIM:602330 actin binding LIM protein 1 GO:0001725,GO:0003779,GO:0005737,GO:0007010,GO:0007601,GO:0009887,GO:0015629,GO:0030027,GO:0030032,GO:0046872,GO:0060271 stress fiber|actin binding|cytoplasm|cytoskeleton organization|visual perception|animal organ morphogenesis|actin cytoskeleton|lamellipodium|lamellipodium assembly|metal ion binding|cilium assembly hsa04360 Axon guidance ABLIM2 2.18269899516717 0.490071401957362 3.87532658837698 7.90767747903426 2.98325403079315 0.285159645127938 1 0 0.00756935 0.0160376 0.0374592 GeneID:84448,Genbank:NM_001130086.1,HGNC:HGNC:19195,MIM:612544 actin binding LIM protein family member 2 GO:0003779,GO:0005737,GO:0006351,GO:0015629,GO:0030036,GO:0046872 actin binding|cytoplasm|transcription, DNA-templated|actin cytoskeleton|actin cytoskeleton organization|metal ion binding hsa04360 Axon guidance ABLIM3 686.975490391987 654.713380349671 719.237600434303 1.09855338537632 0.135604980772779 0.401860646928403 1 2.49161 2.36474 2.95888 2.43227 GeneID:22885,Genbank:NM_001301027.2,HGNC:HGNC:29132,MIM:611305 actin binding LIM protein family member 3 GO:0001725,GO:0003779,GO:0005737,GO:0006351,GO:0030027,GO:0030032,GO:0030036,GO:0045944,GO:0046872,GO:0060271,GO:1903955 stress fiber|actin binding|cytoplasm|transcription, DNA-templated|lamellipodium|lamellipodium assembly|actin cytoskeleton organization|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|cilium assembly|positive regulation of protein targeting to mitochondrion hsa04360 Axon guidance ABR 4362.06081705531 4021.19295171693 4702.9286823937 1.16953569223424 0.225935890953774 0.0922458362598663 0.985596606763188 10.4329 10.2417 12.9555 11.7993 GeneID:29,Genbank:NM_001322841.1,HGNC:HGNC:81,MIM:600365 ABR, RhoGEF and GTPase activating protein GO:0002692,GO:0005085,GO:0005089,GO:0005096,GO:0005829,GO:0005886,GO:0007186,GO:0007264,GO:0007420,GO:0016020,GO:0030036,GO:0032496,GO:0035023,GO:0042472,GO:0043065,GO:0043114,GO:0043314,GO:0043547,GO:0050728,GO:0050766,GO:0050885,GO:0051056,GO:0060313 negative regulation of cellular extravasation|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|cytosol|plasma membrane|G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|brain development|membrane|actin cytoskeleton organization|response to lipopolysaccharide|regulation of Rho protein signal transduction|inner ear morphogenesis|positive regulation of apoptotic process|regulation of vascular permeability|negative regulation of neutrophil degranulation|positive regulation of GTPase activity|negative regulation of inflammatory response|positive regulation of phagocytosis|neuromuscular process controlling balance|regulation of small GTPase mediated signal transduction|negative regulation of blood vessel remodeling ABRACL 904.048084094088 912.572096669231 895.524071518945 0.981318708721745 -0.0272063296779605 0.882402779029464 1 31.3243 29.0948 30.0281 33.6655 GeneID:58527,Genbank:NM_021243.2,HGNC:HGNC:21230 ABRA C-terminal like ABRAXAS1 121.133974044881 121.112228865805 121.155719223958 1.00035909138623 0.00051796636907233 0.977816845286009 1 1.03035 0.82111 1.15561 1.00126 GeneID:84142,Genbank:NM_001345962.1,HGNC:HGNC:25829,MIM:611143 abraxas 1, BRCA1 A complex subunit GO:0005634,GO:0005654,GO:0006302,GO:0006303,GO:0010212,GO:0016569,GO:0016579,GO:0016604,GO:0031593,GO:0045739,GO:0070531,GO:0072425 nucleus|nucleoplasm|double-strand break repair|double-strand break repair via nonhomologous end joining|response to ionizing radiation|covalent chromatin modification|protein deubiquitination|nuclear body|polyubiquitin modification-dependent protein binding|positive regulation of DNA repair|BRCA1-A complex|signal transduction involved in G2 DNA damage checkpoint hsa03440 Homologous recombination ABRAXAS2 344.75603650082 345.897046881652 343.615026119988 0.993402601201031 -0.00954957044469163 0.98977274466058 1 4.79946 4.3774 4.77642 4.13002 GeneID:23172,Genbank:NM_032182.3,HGNC:HGNC:28975,MIM:611144 abraxas 2, BRISC complex subunit GO:0000278,GO:0000922,GO:0002931,GO:0005737,GO:0005829,GO:0005874,GO:0007059,GO:0008017,GO:0008608,GO:0016579,GO:0031593,GO:0051301,GO:0070536,GO:0070552,GO:0090307 mitotic cell cycle|spindle pole|response to ischemia|cytoplasm|cytosol|microtubule|chromosome segregation|microtubule binding|attachment of spindle microtubules to kinetochore|protein deubiquitination|polyubiquitin modification-dependent protein binding|cell division|protein K63-linked deubiquitination|BRISC complex|mitotic spindle assembly ABT1 948.551788071643 967.163144386093 929.940431757193 0.961513512125684 -0.0566209630218855 0.695076823772444 1 18.5692 20.8072 17.889 20.2083 GeneID:29777,Genbank:NM_013375.3,HGNC:HGNC:17369 activator of basal transcription 1 GO:0000447,GO:0000472,GO:0000480,GO:0003677,GO:0003713,GO:0003723,GO:0005634,GO:0005667,GO:0005730,GO:0006357,GO:0006366,GO:0021522,GO:0034462 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|DNA binding|transcription coactivator activity|RNA binding|nucleus|transcription factor complex|nucleolus|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|spinal cord motor neuron differentiation|small-subunit processome assembly ABTB1 87.4334103496901 85.2135720099334 89.6532486894469 1.05210058180634 0.0732726342278486 0.889440562489146 1 1.1203 1.83145 1.67368 1.66905 GeneID:80325,Genbank:XM_017007288.1,HGNC:HGNC:18275,MIM:608308 ankyrin repeat and BTB domain containing 1 GO:0003746,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0019005,GO:0030162,GO:0031625,GO:0042787,GO:0043161 translation elongation factor activity|nucleolus|cytoplasm|cytosol|plasma membrane|SCF ubiquitin ligase complex|regulation of proteolysis|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process ABTB2 505.395913499292 504.832034593291 505.959792405292 1.00223392680084 0.00321928063594367 1 1 4.22042 4.48159 4.62577 4.23144 GeneID:25841,Genbank:NM_145804.2,HGNC:HGNC:23842 ankyrin repeat and BTB domain containing 2 GO:0005634,GO:0005654,GO:0005737,GO:0019005,GO:0030162,GO:0031625,GO:0042787,GO:0043161,GO:0046982,GO:0097237 nucleus|nucleoplasm|cytoplasm|SCF ubiquitin ligase complex|regulation of proteolysis|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein heterodimerization activity|cellular response to toxic substance ACAA1 2078.0697942967 1940.53352086336 2215.60606773004 1.14175098956512 0.191248040112658 0.18116219708052 1 27.953 30.9901 33.045 34.8844 GeneID:30,Genbank:NM_001130410.1,HGNC:HGNC:82,MIM:604054 acetyl-CoA acyltransferase 1 GO:0000038,GO:0003988,GO:0005576,GO:0005777,GO:0005782,GO:0006635,GO:0008206,GO:0008775,GO:0016020,GO:0016401,GO:0033540,GO:0035580,GO:0036109,GO:0043231,GO:0043312 very long-chain fatty acid metabolic process|acetyl-CoA C-acyltransferase activity|extracellular region|peroxisome|peroxisomal matrix|fatty acid beta-oxidation|bile acid metabolic process|acetate CoA-transferase activity|membrane|palmitoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA oxidase|specific granule lumen|alpha-linolenic acid metabolic process|intracellular membrane-bounded organelle|neutrophil degranulation hsa00071,hsa00280,hsa00592,hsa01040,hsa03320,hsa04146 Fatty acid degradation|Valine, leucine and isoleucine degradation|alpha-Linolenic acid metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|Peroxisome ACAA2 621.9064661167 615.258745165404 628.554187067997 1.02160951308221 0.0308438643864582 0.854991904190347 1 11.662 11.6673 12.3578 11.9884 GeneID:10449,Genbank:NM_006111.2,HGNC:HGNC:83,MIM:604770 acetyl-CoA acyltransferase 2 GO:0003723,GO:0003988,GO:0005739,GO:0005743,GO:0005759,GO:0006635,GO:0006695,GO:0070062,GO:0071456,GO:1901029,GO:1902109 RNA binding|acetyl-CoA C-acyltransferase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|fatty acid beta-oxidation|cholesterol biosynthetic process|extracellular exosome|cellular response to hypoxia|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|negative regulation of mitochondrial membrane permeability involved in apoptotic process hsa00062,hsa00071,hsa00280 Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation ACACA 4813.66767429591 4748.34862166032 4878.98672693151 1.02751232390041 0.0391556975793499 0.770669990244792 1 13.1666 13.2523 14.6659 12.6333 GeneID:31,Genbank:XM_011524701.1,HGNC:HGNC:84,MIM:200350 acetyl-CoA carboxylase alpha hsa00061,hsa00620,hsa00640,hsa04152,hsa04910,hsa04922 Fatty acid biosynthesis|Pyruvate metabolism|Propanoate metabolism|AMPK signaling pathway|Insulin signaling pathway|Glucagon signaling pathway ACACB 229.48148306781 205.489736895878 253.473229239741 1.23350797499038 0.302767043114223 0.162182417577132 1 0.648082 0.578465 0.866701 0.734235 GeneID:32,Genbank:XM_011538265.2,HGNC:HGNC:85,MIM:601557 acetyl-CoA carboxylase beta GO:0003989,GO:0004075,GO:0005524,GO:0005634,GO:0005739,GO:0005741,GO:0005829,GO:0006084,GO:0006633,GO:0006768,GO:0006853,GO:0009374,GO:0010629,GO:0010884,GO:0010906,GO:0012505,GO:0014070,GO:0031325,GO:0031667,GO:0031999,GO:0042493,GO:0042802,GO:0043086,GO:0045540,GO:0046872,GO:0051289,GO:0060421,GO:0097009,GO:2001295 acetyl-CoA carboxylase activity|biotin carboxylase activity|ATP binding|nucleus|mitochondrion|mitochondrial outer membrane|cytosol|acetyl-CoA metabolic process|fatty acid biosynthetic process|biotin metabolic process|carnitine shuttle|biotin binding|negative regulation of gene expression|positive regulation of lipid storage|regulation of glucose metabolic process|endomembrane system|response to organic cyclic compound|positive regulation of cellular metabolic process|response to nutrient levels|negative regulation of fatty acid beta-oxidation|response to drug|identical protein binding|negative regulation of catalytic activity|regulation of cholesterol biosynthetic process|metal ion binding|protein homotetramerization|positive regulation of heart growth|energy homeostasis|malonyl-CoA biosynthetic process hsa00061,hsa00620,hsa00640,hsa04152,hsa04910,hsa04920,hsa04922,hsa04931 Fatty acid biosynthesis|Pyruvate metabolism|Propanoate metabolism|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance ACAD10 351.556003213316 305.731826232219 397.380180194412 1.29976713609325 0.378253175795341 0.0491298085799219 0.812875014685981 2.64678 2.73904 3.24607 3.72875 GeneID:80724,Genbank:NM_001136538.1,HGNC:HGNC:21597,MIM:611181 acyl-CoA dehydrogenase family member 10 GO:0003995,GO:0005739,GO:0005759,GO:0006635,GO:0016787,GO:0033539,GO:0050660 acyl-CoA dehydrogenase activity|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|hydrolase activity|fatty acid beta-oxidation using acyl-CoA dehydrogenase|flavin adenine dinucleotide binding ACAD11 188.020305963984 167.639586086431 208.401025841537 1.24314925076283 0.313999514740481 0.17427992674918 1 1.6876 1.6701 2.21563 1.94722 GeneID:84129,Genbank:NM_032169.4,HGNC:HGNC:30211,MIM:614288 acyl-CoA dehydrogenase family member 11 GO:0003995,GO:0004466,GO:0005634,GO:0005743,GO:0005777,GO:0006635,GO:0017099,GO:0031966,GO:0033539,GO:0050660,GO:0070991 acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|nucleus|mitochondrial inner membrane|peroxisome|fatty acid beta-oxidation|very-long-chain-acyl-CoA dehydrogenase activity|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|flavin adenine dinucleotide binding|medium-chain-acyl-CoA dehydrogenase activity ACAD8 446.355039984852 467.721895214333 424.988184755371 0.908634359656437 -0.138228233506913 0.426490022609601 1 2.37739 3.01907 2.36338 2.7658 GeneID:27034,Genbank:XM_017017546.2,HGNC:HGNC:87,MIM:604773 acyl-CoA dehydrogenase family member 8 GO:0003995,GO:0005759,GO:0006351,GO:0006355,GO:0006574,GO:0006629,GO:0009083,GO:0050660 acyl-CoA dehydrogenase activity|mitochondrial matrix|transcription, DNA-templated|regulation of transcription, DNA-templated|valine catabolic process|lipid metabolic process|branched-chain amino acid catabolic process|flavin adenine dinucleotide binding hsa00280 Valine, leucine and isoleucine degradation ACAD9 1167.79029811524 1149.25391550186 1186.32668072862 1.03225811522301 0.045803760481615 0.763092290076547 1 14.2524 14.1977 14.7132 14.9376 GeneID:28976,Genbank:NM_014049.4,HGNC:HGNC:21497,MIM:611103 acyl-CoA dehydrogenase family member 9 GO:0001676,GO:0004466,GO:0005634,GO:0005739,GO:0005743,GO:0030425,GO:0031966,GO:0032981,GO:0050660,GO:0051791,GO:0070991 long-chain fatty acid metabolic process|long-chain-acyl-CoA dehydrogenase activity|nucleus|mitochondrion|mitochondrial inner membrane|dendrite|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|flavin adenine dinucleotide binding|medium-chain fatty acid metabolic process|medium-chain-acyl-CoA dehydrogenase activity ACADL 11.8907270564284 13.6063293952204 10.1751247176364 0.747822900804586 -0.419231442932624 0.676579971188568 1 0.218598 0.111001 0.0979442 0.142985 GeneID:33,Genbank:NM_001608.3,HGNC:HGNC:88,MIM:609576 acyl-CoA dehydrogenase long chain GO:0000062,GO:0001659,GO:0003995,GO:0004466,GO:0005759,GO:0006635,GO:0016401,GO:0019254,GO:0031966,GO:0033539,GO:0042413,GO:0042758,GO:0044242,GO:0045717,GO:0046322,GO:0050660,GO:0051289,GO:0055114,GO:0090181 fatty-acyl-CoA binding|temperature homeostasis|acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|mitochondrial matrix|fatty acid beta-oxidation|palmitoyl-CoA oxidase activity|carnitine metabolic process, CoA-linked|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|carnitine catabolic process|long-chain fatty acid catabolic process|cellular lipid catabolic process|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|flavin adenine dinucleotide binding|protein homotetramerization|oxidation-reduction process|regulation of cholesterol metabolic process hsa00071,hsa03320 Fatty acid degradation|PPAR signaling pathway ACADM 948.873011538166 1032.60813018175 865.13789289458 0.837818207708964 -0.255290857274007 0.103058696664235 1 14.6295 13.1864 13.1999 9.94219 GeneID:34,Genbank:NM_001127328.2,HGNC:HGNC:89,MIM:607008 acyl-CoA dehydrogenase medium chain GO:0003995,GO:0005634,GO:0005739,GO:0005759,GO:0006635,GO:0016607,GO:0019216,GO:0019254,GO:0030424,GO:0031966,GO:0033539,GO:0042802,GO:0045329,GO:0050660,GO:0051791,GO:0051793,GO:0055114,GO:0070062,GO:0070991 acyl-CoA dehydrogenase activity|nucleus|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|nuclear speck|regulation of lipid metabolic process|carnitine metabolic process, CoA-linked|axon|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|identical protein binding|carnitine biosynthetic process|flavin adenine dinucleotide binding|medium-chain fatty acid metabolic process|medium-chain fatty acid catabolic process|oxidation-reduction process|extracellular exosome|medium-chain-acyl-CoA dehydrogenase activity hsa00071,hsa00280,hsa00410,hsa00640,hsa03320 Fatty acid degradation|Valine, leucine and isoleucine degradation|beta-Alanine metabolism|Propanoate metabolism|PPAR signaling pathway ACADS 206.344720386391 182.053570497042 230.635870275741 1.26685716542697 0.341253873850098 0.400411345830005 1 3.08608 3.79002 3.82476 5.92713 GeneID:35,Genbank:NM_000017.3,HGNC:HGNC:90,MIM:606885 acyl-CoA dehydrogenase short chain hsa00071,hsa00280,hsa00650 Fatty acid degradation|Valine, leucine and isoleucine degradation|Butanoate metabolism ACADSB 318.29019347245 329.830551821537 306.749835123363 0.930022502249391 -0.10466247168727 0.62454301304516 1 2.17823 1.91867 1.80362 1.98766 GeneID:36,Genbank:NM_001609.3,HGNC:HGNC:91,MIM:600301 acyl-CoA dehydrogenase short/branched chain GO:0003995,GO:0005739,GO:0005759,GO:0006631,GO:0009083,GO:0050660,GO:0070062 acyl-CoA dehydrogenase activity|mitochondrion|mitochondrial matrix|fatty acid metabolic process|branched-chain amino acid catabolic process|flavin adenine dinucleotide binding|extracellular exosome hsa00071,hsa00280 Fatty acid degradation|Valine, leucine and isoleucine degradation ACADVL 8066.23401875924 7493.16437002057 8639.3036674979 1.15295798155222 0.205339936310721 0.121627645683848 1 83.7006 85.6006 101.427 100.298 GeneID:37,Genbank:NM_001270447.1,HGNC:HGNC:92,MIM:609575 acyl-CoA dehydrogenase very long chain GO:0001659,GO:0003995,GO:0004466,GO:0005634,GO:0005730,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006635,GO:0009409,GO:0015980,GO:0030855,GO:0031966,GO:0033539,GO:0036498,GO:0042645,GO:0045717,GO:0046322,GO:0050660,GO:0090181 temperature homeostasis|acyl-CoA dehydrogenase activity|long-chain-acyl-CoA dehydrogenase activity|nucleus|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|fatty acid beta-oxidation|response to cold|energy derivation by oxidation of organic compounds|epithelial cell differentiation|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|IRE1-mediated unfolded protein response|mitochondrial nucleoid|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|flavin adenine dinucleotide binding|regulation of cholesterol metabolic process hsa00071 Fatty acid degradation ACAP1 13.7365792950389 13.904295698438 13.5688628916398 0.975875598874393 -0.0352308449739836 1 1 0.052531 0.0768774 0.0653534 0.030511 GeneID:9744,Genbank:XM_024451047.1,HGNC:HGNC:16467,MIM:607763 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 GO:0005096,GO:0015031,GO:0016020,GO:0046872,GO:0055038 GTPase activator activity|protein transport|membrane|metal ion binding|recycling endosome membrane hsa04144 Endocytosis ACAP2 442.411775275128 465.067590448989 419.755960101266 0.902569795706517 -0.147889594991445 0.709922522369173 1 2.6442 1.92467 2.50507 1.64846 GeneID:23527,Genbank:NM_012287.5,HGNC:HGNC:16469,MIM:607766 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 GO:0005096,GO:0010008,GO:0016020,GO:0017137,GO:0036010,GO:0046872,GO:0080025,GO:1990090 GTPase activator activity|endosome membrane|membrane|Rab GTPase binding|protein localization to endosome|metal ion binding|phosphatidylinositol-3,5-bisphosphate binding|cellular response to nerve growth factor stimulus hsa04144 Endocytosis ACAP3 1057.81829647334 971.439516834763 1144.19707611191 1.17783666021745 0.23613948328282 0.127949585855229 1 5.41875 5.82687 6.84655 6.57876 GeneID:116983,Genbank:XM_005244715.2,HGNC:HGNC:16754 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 GO:0005096,GO:0046872 GTPase activator activity|metal ion binding hsa04144 Endocytosis ACAT1 1259.15192665483 1159.8805818649 1358.42327144476 1.17117511292467 0.227956802278281 0.118793565392442 1 10.1384 9.82342 11.846 11.2921 GeneID:38,Genbank:XM_024448512.1,HGNC:HGNC:93,MIM:607809 acetyl-CoA acetyltransferase 1 GO:0001889,GO:0003985,GO:0005739,GO:0005743,GO:0005759,GO:0006085,GO:0006550,GO:0006635,GO:0007420,GO:0009083,GO:0009725,GO:0014070,GO:0015936,GO:0015937,GO:0016830,GO:0016885,GO:0019899,GO:0042594,GO:0042803,GO:0046356,GO:0046872,GO:0046951,GO:0046952,GO:0050662,GO:0051260,GO:0060612,GO:0070062,GO:0072229,GO:1902224,GO:1902860 liver development|acetyl-CoA C-acetyltransferase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|acetyl-CoA biosynthetic process|isoleucine catabolic process|fatty acid beta-oxidation|brain development|branched-chain amino acid catabolic process|response to hormone|response to organic cyclic compound|coenzyme A metabolic process|coenzyme A biosynthetic process|carbon-carbon lyase activity|ligase activity, forming carbon-carbon bonds|enzyme binding|response to starvation|protein homodimerization activity|acetyl-CoA catabolic process|metal ion binding|ketone body biosynthetic process|ketone body catabolic process|coenzyme binding|protein homooligomerization|adipose tissue development|extracellular exosome|metanephric proximal convoluted tubule development|ketone body metabolic process|propionyl-CoA biosynthetic process hsa00071,hsa00072,hsa00280,hsa00310,hsa00380,hsa00620,hsa00630,hsa00640,hsa00650,hsa00900 Fatty acid degradation|Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism|Butanoate metabolism|Terpenoid backbone biosynthesis ACAT2 3707.77219149753 3564.7907250223 3850.75365797275 1.08021871548958 0.111323449245993 0.410891664272208 1 70.2786 71.8376 78.3339 78.5698 GeneID:39,Genbank:NM_005891.2,HGNC:HGNC:94,MIM:100678 acetyl-CoA acetyltransferase 2 GO:0003985,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006629,GO:0006635,GO:0006695,GO:0070062 acetyl-CoA C-acetyltransferase activity|nucleus|nucleolus|cytoplasm|mitochondrion|cytosol|lipid metabolic process|fatty acid beta-oxidation|cholesterol biosynthetic process|extracellular exosome hsa00071,hsa00072,hsa00280,hsa00310,hsa00380,hsa00620,hsa00630,hsa00640,hsa00650,hsa00900,hsa04975 Fatty acid degradation|Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism|Butanoate metabolism|Terpenoid backbone biosynthesis|Fat digestion and absorption ACBD3 716.108028154174 726.549928681846 705.666127626503 0.97125620658551 -0.0420761821324955 0.825252487530561 1 8.19115 7.25414 8.34195 6.79403 GeneID:64746,Genbank:NM_022735.3,HGNC:HGNC:15453,MIM:606809 acyl-CoA binding domain containing 3 GO:0000062,GO:0000139,GO:0005739,GO:0005794,GO:0006694,GO:0016020,GO:0034237 fatty-acyl-CoA binding|Golgi membrane|mitochondrion|Golgi apparatus|steroid biosynthetic process|membrane|protein kinase A regulatory subunit binding ACBD4 161.999645113817 140.820946148577 183.178344079057 1.30078904515944 0.379387012648045 0.126282522232369 1 0.944089 0.998282 1.21315 1.23732 GeneID:79777,Genbank:XM_017025088.1,HGNC:HGNC:23337 acyl-CoA binding domain containing 4 GO:0000062,GO:0008289 fatty-acyl-CoA binding|lipid binding ACBD5 525.403076234351 536.560180204971 514.245972263731 0.958412478666016 -0.0612814025449108 0.738609158736494 1 2.47336 2.39927 2.70772 2.07226 GeneID:91452,Genbank:NM_001352570.1,HGNC:HGNC:23338,MIM:616618 acyl-CoA binding domain containing 5 GO:0000062,GO:0005778,GO:0008289,GO:0016021,GO:0030242 fatty-acyl-CoA binding|peroxisomal membrane|lipid binding|integral component of membrane|autophagy of peroxisome ACBD6 1318.74390993831 1394.48644523011 1243.00137464651 0.891368560015938 -0.165906019183611 0.261875581330723 1 35.9703 34.8986 30.8817 33.5443 GeneID:84320,Genbank:NM_032360.3,HGNC:HGNC:23339,MIM:616352 acyl-CoA binding domain containing 6 GO:0000062,GO:0005829,GO:0006637,GO:0008289 fatty-acyl-CoA binding|cytosol|acyl-CoA metabolic process|lipid binding ACBD7 298.821067111959 313.159332500734 284.482801723184 0.908428305334049 -0.138555435816514 0.496616615552281 1 3.80205 3.82073 3.61541 3.20516 GeneID:414149,Genbank:NM_001039844.2,HGNC:HGNC:17715 acyl-CoA binding domain containing 7 GO:0000062,GO:0008289 fatty-acyl-CoA binding|lipid binding ACCS 21.4739856186427 14.3463408257104 28.6016304115751 1.99365334750151 0.995414578583969 0.133710071088175 1 0.096396 0.118706 0.21377 0.157523 GeneID:84680,Genbank:XM_024448723.1,HGNC:HGNC:23989,MIM:608405 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) GO:0003824,GO:0009058,GO:0030170,GO:0042802,GO:0042803 catalytic activity|biosynthetic process|pyridoxal phosphate binding|identical protein binding|protein homodimerization activity ACCSL 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0175951 0 0 0 GeneID:390110,Genbank:NM_001031854.2,HGNC:HGNC:34391 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like GO:0003824,GO:0009058,GO:0030170 catalytic activity|biosynthetic process|pyridoxal phosphate binding ACD 712.465689162968 706.757001506521 718.174376819415 1.01615459809886 0.0231199109124075 0.907225716018924 1 13.3612 13.8892 13.4885 14.7763 GeneID:65057,Genbank:NM_001082487.1,HGNC:HGNC:25070,MIM:609377 ACD, shelterin complex subunit and telomerase recruitment factor GO:0000723,GO:0000783,GO:0000784,GO:0005654,GO:0006886,GO:0016233,GO:0016604,GO:0031848,GO:0032202,GO:0032211,GO:0032212,GO:0042162,GO:0044877,GO:0051973,GO:0060381,GO:0070182,GO:0070187,GO:0070198,GO:0070200 telomere maintenance|nuclear telomere cap complex|nuclear chromosome, telomeric region|nucleoplasm|intracellular protein transport|telomere capping|nuclear body|protection from non-homologous end joining at telomere|telomere assembly|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|telomeric DNA binding|macromolecular complex binding|positive regulation of telomerase activity|positive regulation of single-stranded telomeric DNA binding|DNA polymerase binding|shelterin complex|protein localization to chromosome, telomeric region|establishment of protein localization to telomere ACE 2.04883350814404 2.64246210852658 1.45520490776151 0.550700387742901 -0.860660470610369 0.823907273591537 1 0.0233458 0.00674568 0.0216279 0 GeneID:1636,Genbank:NM_000789.3,HGNC:HGNC:2707,MIM:106180 angiotensin I converting enzyme hsa04614,hsa04924,hsa05142,hsa05410 Renin-angiotensin system|Renin secretion|Chagas disease (American trypanosomiasis)|Hypertrophic cardiomyopathy (HCM) ACE2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0075081 0 0 0 GeneID:59272,Genbank:XM_011545551.3,HGNC:HGNC:13557,MIM:300335 angiotensin I converting enzyme 2 hsa04614,hsa04974 Renin-angiotensin system|Protein digestion and absorption ACER2 40.6775261860927 46.4597136357248 34.8953387364607 0.751088114964796 -0.412945925409281 0.374473766903312 1 0.363263 0.274365 0.293947 0.221777 GeneID:340485,Genbank:NM_001010887.2,HGNC:HGNC:23675,MIM:613492 alkaline ceramidase 2 GO:0000139,GO:0001953,GO:0005794,GO:0006672,GO:0006919,GO:0008284,GO:0010942,GO:0017040,GO:0030148,GO:0030173,GO:0032526,GO:0033629,GO:0035690,GO:0046512,GO:0071633,GO:0090285 Golgi membrane|negative regulation of cell-matrix adhesion|Golgi apparatus|ceramide metabolic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of cell proliferation|positive regulation of cell death|ceramidase activity|sphingolipid biosynthetic process|integral component of Golgi membrane|response to retinoic acid|negative regulation of cell adhesion mediated by integrin|cellular response to drug|sphingosine biosynthetic process|dihydroceramidase activity|negative regulation of protein glycosylation in Golgi hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway ACER3 413.090443326169 452.009167385519 374.17171926682 0.827796748970997 -0.272651512244056 0.342177827158259 1 2.17326 1.6137 1.87384 1.35875 GeneID:55331,Genbank:NM_018367.6,HGNC:HGNC:16066,MIM:617036 alkaline ceramidase 3 GO:0005789,GO:0006672,GO:0008284,GO:0030148,GO:0030173,GO:0030176,GO:0046512,GO:0070774,GO:0071602 endoplasmic reticulum membrane|ceramide metabolic process|positive regulation of cell proliferation|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|sphingosine biosynthetic process|phytoceramidase activity|phytosphingosine biosynthetic process hsa00600 Sphingolipid metabolism ACHE 39.4006199536884 36.6298766321084 42.1713632752683 1.15128324615493 0.203242818310351 0.694899752901001 1 0.364038 0.542332 0.714438 0.35764 GeneID:43,Genbank:NM_001302622.1,HGNC:HGNC:108,MIM:100740 acetylcholinesterase (Cartwright blood group) hsa00564,hsa04725 Glycerophospholipid metabolism|Cholinergic synapse ACIN1 4442.60350115331 4666.49790587919 4218.70909642744 0.904041784978068 -0.145538639074913 0.276894133548235 1 15.9781 15.6981 14.811 14.2313 GeneID:22985,Genbank:NM_001164815.1,HGNC:HGNC:17066,MIM:604562 apoptotic chromatin condensation inducer 1 GO:0003676,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006397,GO:0008380,GO:0016607,GO:0016887,GO:0019899,GO:0030218,GO:0030263,GO:0043065,GO:0045657,GO:0048025,GO:0061574,GO:0097194 nucleic acid binding|RNA binding|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|mRNA processing|RNA splicing|nuclear speck|ATPase activity|enzyme binding|erythrocyte differentiation|apoptotic chromosome condensation|positive regulation of apoptotic process|positive regulation of monocyte differentiation|negative regulation of mRNA splicing, via spliceosome|ASAP complex|execution phase of apoptosis hsa03013,hsa03015,hsa03040 RNA transport|mRNA surveillance pathway|Spliceosome ACKR2 4.52916259231833 4.69880026572591 4.35952491891075 0.92779532484283 -0.10812151841621 1 1 0.0775554 0.0525111 0.0182393 0.0850716 GeneID:1238,Genbank:NM_001296.4,HGNC:HGNC:1565,MIM:602648 atypical chemokine receptor 2 GO:0004950,GO:0005044,GO:0005654,GO:0005769,GO:0005829,GO:0005884,GO:0005886,GO:0005887,GO:0006935,GO:0006954,GO:0006955,GO:0007186,GO:0007275,GO:0016493,GO:0019957,GO:0031965,GO:0043231,GO:0055037 chemokine receptor activity|scavenger receptor activity|nucleoplasm|early endosome|cytosol|actin filament|plasma membrane|integral component of plasma membrane|chemotaxis|inflammatory response|immune response|G-protein coupled receptor signaling pathway|multicellular organism development|C-C chemokine receptor activity|C-C chemokine binding|nuclear membrane|intracellular membrane-bounded organelle|recycling endosome ACKR3 8.37616159013434 12.8761266198383 3.87619656043037 0.301037468399721 -1.73198503278497 0.0992169119416276 1 0.28368 0.23456 0.0613639 0.0570592 GeneID:57007,Genbank:XM_005246098.3,HGNC:HGNC:23692,MIM:610376 atypical chemokine receptor 3 hsa04060 Cytokine-cytokine receptor interaction ACLY 10588.4985059005 12123.5214536688 9053.47555813229 0.746769459082581 -0.421265168570015 0.00329750519507857 0.215562625323993 78.9896 80.021 55.5853 65.4077 GeneID:47,Genbank:XM_017024688.1,HGNC:HGNC:115,MIM:108728 ATP citrate lyase hsa00020 Citrate cycle (TCA cycle) ACMSD 1.50986585944834 1.56626675524197 1.45346496365472 0.927980472541008 -0.107833647793846 1 1 0 0 0.00755377 0 GeneID:130013,Genbank:XM_005263586.4,HGNC:HGNC:19288,MIM:608889 aminocarboxymuconate semialdehyde decarboxylase GO:0001760,GO:0005829,GO:0006569,GO:0008270,GO:0016787,GO:0051259,GO:0070062,GO:1904985,GO:1905004,GO:1905012 aminocarboxymuconate-semialdehyde decarboxylase activity|cytosol|tryptophan catabolic process|zinc ion binding|hydrolase activity|protein oligomerization|extracellular exosome|negative regulation of quinolinate biosynthetic process|picolinic acid biosynthetic process|regulation of 'de novo' NAD biosynthetic process from tryptophan hsa00380 Tryptophan metabolism ACO1 1336.70622170886 1316.10546388311 1357.30697953462 1.03130563376733 0.0444719476205709 0.805577995352747 1 13.2875 13.5238 12.4639 15.2507 GeneID:48,Genbank:NM_001278352.1,HGNC:HGNC:117,MIM:100880 aconitase 1 hsa00020,hsa00630 Citrate cycle (TCA cycle)|Glyoxylate and dicarboxylate metabolism ACO2 3614.9440123312 2872.78694285175 4357.10108181065 1.51668089854427 0.60091758228001 1.02171536556175e-05 0.0045454981374547 26.7622 28.9657 42.4995 44.6071 GeneID:50,Genbank:XM_024452250.1,HGNC:HGNC:118,MIM:100850 aconitase 2 hsa00020,hsa00630 Citrate cycle (TCA cycle)|Glyoxylate and dicarboxylate metabolism ACOT1 2.20964866822144 1.02816907859967 3.3911282578432 3.29822042738517 1.7216878205063 0.50984760331402 1 0.0222788 0.0200935 0.0419863 0.0975473 GeneID:641371,Genbank:XM_017021591.1,HGNC:HGNC:33128,MIM:614313 acyl-CoA thioesterase 1 GO:0000038,GO:0001676,GO:0005102,GO:0005739,GO:0005759,GO:0006637,GO:0016290,GO:0047617,GO:0052689,GO:0070062,GO:0102991 very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|receptor binding|mitochondrion|mitochondrial matrix|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|extracellular exosome|myristoyl-CoA hydrolase activity hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids ACOT11 15.727719855504 19.8233701415033 11.6320695695047 0.586785671985772 -0.769094450882604 0.312098414569612 1 0.197602 0.114352 0.08578 0.114408 GeneID:26027,Genbank:NM_015547.3,HGNC:HGNC:18156,MIM:606803 acyl-CoA thioesterase 11 GO:0005829,GO:0006631,GO:0006637,GO:0008289,GO:0009266,GO:0009409,GO:0035556,GO:0047617,GO:0052689,GO:0070062 cytosol|fatty acid metabolic process|acyl-CoA metabolic process|lipid binding|response to temperature stimulus|response to cold|intracellular signal transduction|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|extracellular exosome ACOT12 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0.0174076 0 0 GeneID:134526,Genbank:XM_017009047.1,HGNC:HGNC:24436,MIM:614315 acyl-CoA thioesterase 12 GO:0003986,GO:0005524,GO:0005829,GO:0006084,GO:0006090,GO:0006631,GO:0006637,GO:0008289,GO:0047617,GO:0052689 acetyl-CoA hydrolase activity|ATP binding|cytosol|acetyl-CoA metabolic process|pyruvate metabolic process|fatty acid metabolic process|acyl-CoA metabolic process|lipid binding|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity hsa00620 Pyruvate metabolism ACOT13 743.897061696805 695.937213043882 791.856910349728 1.13782809067834 0.186282603812811 0.255507116559341 1 3.50201 4.5329 4.61683 4.8558 GeneID:55856,Genbank:NM_001160094.1,HGNC:HGNC:20999,MIM:615652 acyl-CoA thioesterase 13 GO:0005634,GO:0005737,GO:0005739,GO:0005819,GO:0005829,GO:0006637,GO:0047617,GO:0051289,GO:0070062 nucleus|cytoplasm|mitochondrion|spindle|cytosol|acyl-CoA metabolic process|acyl-CoA hydrolase activity|protein homotetramerization|extracellular exosome ACOT2 466.689203908156 439.557502584447 493.820905231866 1.12345006586935 0.167936002289418 0.355774379044424 1 9.05666 8.95336 9.91914 10.6187 GeneID:10965,Genbank:NM_006821.5,HGNC:HGNC:18431,MIM:609972 acyl-CoA thioesterase 2 GO:0000038,GO:0001676,GO:0005102,GO:0005739,GO:0005759,GO:0006637,GO:0016290,GO:0047617,GO:0052689,GO:0070062,GO:0102991 very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|receptor binding|mitochondrion|mitochondrial matrix|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|extracellular exosome|myristoyl-CoA hydrolase activity hsa00062,hsa01040,hsa04913 Fatty acid elongation|Biosynthesis of unsaturated fatty acids|Ovarian steroidogenesis ACOT4 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:122970,Genbank:NM_152331.3,HGNC:HGNC:19748,MIM:614314 acyl-CoA thioesterase 4 GO:0000038,GO:0001676,GO:0004778,GO:0005102,GO:0005777,GO:0005782,GO:0006104,GO:0006637,GO:0016290,GO:0032788,GO:0032789,GO:0043648,GO:0043649,GO:0046459,GO:0047617,GO:0052689,GO:0102991 very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|succinyl-CoA hydrolase activity|receptor binding|peroxisome|peroxisomal matrix|succinyl-CoA metabolic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|saturated monocarboxylic acid metabolic process|unsaturated monocarboxylic acid metabolic process|dicarboxylic acid metabolic process|dicarboxylic acid catabolic process|short-chain fatty acid metabolic process|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|myristoyl-CoA hydrolase activity hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids ACOT7 3146.35214038218 3089.94234084524 3202.76193991913 1.03651187842005 0.0517366498187687 0.725917598803443 1 49.0636 51.5185 52.3948 55.8582 GeneID:11332,Genbank:NM_007274.3,HGNC:HGNC:24157,MIM:602587 acyl-CoA thioesterase 7 GO:0000062,GO:0005654,GO:0005739,GO:0005829,GO:0006637,GO:0015937,GO:0016290,GO:0036042,GO:0036114,GO:0036116,GO:0042803,GO:0047617,GO:0051792,GO:0052689,GO:0070062,GO:0102991,GO:1900535 fatty-acyl-CoA binding|nucleoplasm|mitochondrion|cytosol|acyl-CoA metabolic process|coenzyme A biosynthetic process|palmitoyl-CoA hydrolase activity|long-chain fatty acyl-CoA binding|medium-chain fatty-acyl-CoA catabolic process|long-chain fatty-acyl-CoA catabolic process|protein homodimerization activity|acyl-CoA hydrolase activity|medium-chain fatty acid biosynthetic process|carboxylic ester hydrolase activity|extracellular exosome|myristoyl-CoA hydrolase activity|palmitic acid biosynthetic process hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids ACOT8 518.050418711703 496.241072076375 539.85976534703 1.08789819248162 0.121543552843587 0.488160977622618 1 14.2644 14.2459 15.502 15.2527 GeneID:10005,Genbank:NM_005469.3,HGNC:HGNC:15919,MIM:608123 acyl-CoA thioesterase 8 GO:0003986,GO:0005102,GO:0005739,GO:0005782,GO:0006637,GO:0006699,GO:0009062,GO:0016032,GO:0016289,GO:0016290,GO:0016559,GO:0033540,GO:0033882,GO:0036109,GO:0043649,GO:0045225,GO:0047617,GO:0052689,GO:0052815 acetyl-CoA hydrolase activity|receptor binding|mitochondrion|peroxisomal matrix|acyl-CoA metabolic process|bile acid biosynthetic process|fatty acid catabolic process|viral process|CoA hydrolase activity|palmitoyl-CoA hydrolase activity|peroxisome fission|fatty acid beta-oxidation using acyl-CoA oxidase|choloyl-CoA hydrolase activity|alpha-linolenic acid metabolic process|dicarboxylic acid catabolic process|negative regulation of CD4 biosynthetic process|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity|medium-chain acyl-CoA hydrolase activity hsa00120,hsa04146 Primary bile acid biosynthesis|Peroxisome ACOT9 773.277456977419 759.020119725725 787.534794229113 1.03756774525778 0.0532055365141919 0.743459598017572 1 5.72387 5.93652 6.39765 6.06566 GeneID:23597,Genbank:NM_001330259.1,HGNC:HGNC:17152,MIM:300862 acyl-CoA thioesterase 9 GO:0003986,GO:0005739,GO:0005759,GO:0006637,GO:0047617,GO:0052689 acetyl-CoA hydrolase activity|mitochondrion|mitochondrial matrix|acyl-CoA metabolic process|acyl-CoA hydrolase activity|carboxylic ester hydrolase activity ACOX1 1042.364186022 1065.03029495095 1019.69807709305 0.957435748003782 -0.0627524215798816 0.682077684314448 1 4.97154 4.97385 5.16287 4.50509 GeneID:51,Genbank:NM_004035.6,HGNC:HGNC:119,MIM:609751 acyl-CoA oxidase 1 GO:0000038,GO:0003995,GO:0003997,GO:0005102,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0005886,GO:0006091,GO:0006629,GO:0006693,GO:0007283,GO:0016020,GO:0016401,GO:0016559,GO:0019216,GO:0019395,GO:0030165,GO:0033539,GO:0033540,GO:0036109,GO:0043231,GO:0047485,GO:0050660,GO:0055088,GO:0071949,GO:2000189 very long-chain fatty acid metabolic process|acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|receptor binding|nucleus|nucleoplasm|nucleolus|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|plasma membrane|generation of precursor metabolites and energy|lipid metabolic process|prostaglandin metabolic process|spermatogenesis|membrane|palmitoyl-CoA oxidase activity|peroxisome fission|regulation of lipid metabolic process|fatty acid oxidation|PDZ domain binding|fatty acid beta-oxidation using acyl-CoA dehydrogenase|fatty acid beta-oxidation using acyl-CoA oxidase|alpha-linolenic acid metabolic process|intracellular membrane-bounded organelle|protein N-terminus binding|flavin adenine dinucleotide binding|lipid homeostasis|FAD binding|positive regulation of cholesterol homeostasis hsa00071,hsa00592,hsa01040,hsa03320,hsa04024,hsa04146 Fatty acid degradation|alpha-Linolenic acid metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|cAMP signaling pathway|Peroxisome ACOX2 31.7009800459041 25.1181030136644 38.2838570781438 1.52415399591749 0.608008675746229 0.233680271381382 1 0.302214 0.235467 0.464573 0.525119 GeneID:8309,Genbank:NM_003500.3,HGNC:HGNC:120,MIM:601641 acyl-CoA oxidase 2 GO:0003995,GO:0003997,GO:0005102,GO:0005777,GO:0005782,GO:0005829,GO:0006699,GO:0010942,GO:0016402,GO:0033539,GO:0033540,GO:0033791,GO:0042803,GO:0043231,GO:0050660,GO:0071949,GO:1902884 acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|receptor binding|peroxisome|peroxisomal matrix|cytosol|bile acid biosynthetic process|positive regulation of cell death|pristanoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA dehydrogenase|fatty acid beta-oxidation using acyl-CoA oxidase|3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity|protein homodimerization activity|intracellular membrane-bounded organelle|flavin adenine dinucleotide binding|FAD binding|positive regulation of response to oxidative stress hsa00120,hsa03320,hsa04146 Primary bile acid biosynthesis|PPAR signaling pathway|Peroxisome ACOX3 425.796437601233 407.232407365477 444.360467836989 1.09117167445417 0.12587809927778 0.510985968619024 1 2.81561 2.92564 2.97669 3.63623 GeneID:8310,Genbank:XM_011513566.1,HGNC:HGNC:121,MIM:603402 acyl-CoA oxidase 3, pristanoyl GO:0003995,GO:0005102,GO:0005739,GO:0005777,GO:0005782,GO:0016020,GO:0016402,GO:0033539,GO:0033540,GO:0050660,GO:0071949 acyl-CoA dehydrogenase activity|receptor binding|mitochondrion|peroxisome|peroxisomal matrix|membrane|pristanoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA dehydrogenase|fatty acid beta-oxidation using acyl-CoA oxidase|flavin adenine dinucleotide binding|FAD binding hsa00071,hsa00592,hsa01040,hsa03320,hsa04024,hsa04146 Fatty acid degradation|alpha-Linolenic acid metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|cAMP signaling pathway|Peroxisome ACOXL 2.22139481106861 2.98845468642911 1.45433493570811 0.486651158644767 -1.03904010497772 0.699608453666305 1 0.00278277 0.0130562 0.00532236 0 GeneID:55289,Genbank:XM_011511404.3,HGNC:HGNC:25621 acyl-CoA oxidase like GO:0003995,GO:0005782,GO:0016402,GO:0033539,GO:0033540,GO:0050660 acyl-CoA dehydrogenase activity|peroxisomal matrix|pristanoyl-CoA oxidase activity|fatty acid beta-oxidation using acyl-CoA dehydrogenase|fatty acid beta-oxidation using acyl-CoA oxidase|flavin adenine dinucleotide binding ACP1 1803.19781835871 1874.40229056359 1731.99334615384 0.924024343585854 -0.113997234687633 0.419680200978696 1 33.9179 35.3941 31.3032 32.4293 GeneID:52,Genbank:NM_004300.3,HGNC:HGNC:122,MIM:171500 acid phosphatase 1 GO:0003993,GO:0004726,GO:0005737,GO:0005829,GO:0009898,GO:0042383,GO:0070062 acid phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|cytoplasm|cytosol|cytoplasmic side of plasma membrane|sarcolemma|extracellular exosome hsa00730,hsa00740,hsa04520 Thiamine metabolism|Riboflavin metabolism|Adherens junction ACP2 1707.54475190428 1669.48988596478 1745.59961784377 1.04558861513259 0.0643153375799731 0.668285642581929 1 19.5406 20.2926 22.6076 22.1896 GeneID:53,Genbank:NM_001302490.1,HGNC:HGNC:123,MIM:171650 acid phosphatase 2, lysosomal GO:0001501,GO:0003993,GO:0005764,GO:0005765,GO:0007040,GO:0016020,GO:0016021,GO:0043202,GO:0070062 skeletal system development|acid phosphatase activity|lysosome|lysosomal membrane|lysosome organization|membrane|integral component of membrane|lysosomal lumen|extracellular exosome hsa00740,hsa04142 Riboflavin metabolism|Lysosome ACP4 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:93650,Genbank:NM_033068.2,HGNC:HGNC:14376,MIM:606362 acid phosphatase 4 GO:0003993,GO:0016021,GO:0042476 acid phosphatase activity|integral component of membrane|odontogenesis ACP5 90.8283355206397 87.1640489626549 94.4926220786245 1.08407793354241 0.116468474674856 0.74407570112887 1 1.49771 1.97709 1.70953 2.07822 GeneID:54,Genbank:NM_001111036.2,HGNC:HGNC:124,MIM:171640 acid phosphatase 5, tartrate resistant hsa00740,hsa04142,hsa04380,hsa05323 Riboflavin metabolism|Lysosome|Osteoclast differentiation|Rheumatoid arthritis ACP6 1231.3120344882 1108.0987433934 1354.525325583 1.2223868438249 0.289700921285125 0.0522613295522809 0.836181272836494 3.87062 3.99629 4.96859 4.71797 GeneID:51205,Genbank:XM_011509601.3,HGNC:HGNC:29609,MIM:611471 acid phosphatase 6, lysophosphatidic GO:0003993,GO:0005737,GO:0005739,GO:0005759,GO:0006644,GO:0006654,GO:0052642,GO:2001311 acid phosphatase activity|cytoplasm|mitochondrion|mitochondrial matrix|phospholipid metabolic process|phosphatidic acid biosynthetic process|lysophosphatidic acid phosphatase activity|lysobisphosphatidic acid metabolic process ACPP 3.52154926370123 6.07296192222811 0.97013660517434 0.159746861185391 -2.64614051048666 0.153171044286477 1 0.0182221 0.0692718 0.0174675 0 GeneID:55,Genbank:NM_001134194.1,HGNC:HGNC:125,MIM:171790 acid phosphatase, prostate GO:0003993,GO:0005615,GO:0005622,GO:0005634,GO:0005765,GO:0005886,GO:0006144,GO:0006772,GO:0008253,GO:0009117,GO:0012506,GO:0016021,GO:0016311,GO:0016791,GO:0030175,GO:0035577,GO:0042131,GO:0042802,GO:0042803,GO:0043312,GO:0046085,GO:0051289,GO:0051930,GO:0052642,GO:0060168,GO:0070062 acid phosphatase activity|extracellular space|intracellular|nucleus|lysosomal membrane|plasma membrane|purine nucleobase metabolic process|thiamine metabolic process|5'-nucleotidase activity|nucleotide metabolic process|vesicle membrane|integral component of membrane|dephosphorylation|phosphatase activity|filopodium|azurophil granule membrane|thiamine phosphate phosphatase activity|identical protein binding|protein homodimerization activity|neutrophil degranulation|adenosine metabolic process|protein homotetramerization|regulation of sensory perception of pain|lysophosphatidic acid phosphatase activity|positive regulation of adenosine receptor signaling pathway|extracellular exosome ACRBP 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0 0.0174106 GeneID:84519,Genbank:NM_032489.2,HGNC:HGNC:17195,MIM:608352 acrosin binding protein GO:0001669,GO:0002080,GO:0005576,GO:0005634,GO:0048240 acrosomal vesicle|acrosomal membrane|extracellular region|nucleus|sperm capacitation ACSBG1 94.7919269400263 108.188075971282 81.3957779087709 0.752354427029252 -0.41051563290844 0.439142622788292 1 0.557798 0.354276 0.248061 0.433867 GeneID:23205,Genbank:XM_017022025.2,HGNC:HGNC:29567,MIM:614362 acyl-CoA synthetase bubblegum family member 1 GO:0000038,GO:0001676,GO:0004467,GO:0005524,GO:0005737,GO:0005783,GO:0005829,GO:0031410,GO:0031957,GO:0035338,GO:0042552,GO:0051384,GO:0102391 very long-chain fatty acid metabolic process|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|cytoplasm|endoplasmic reticulum|cytosol|cytoplasmic vesicle|very long-chain fatty acid-CoA ligase activity|long-chain fatty-acyl-CoA biosynthetic process|myelination|response to glucocorticoid|decanoate--CoA ligase activity hsa00061,hsa00071,hsa03320,hsa04920 Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Adipocytokine signaling pathway ACSBG2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:81616,Genbank:NM_001289177.1,HGNC:HGNC:24174,MIM:614363 acyl-CoA synthetase bubblegum family member 2 GO:0004467,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006631,GO:0007275,GO:0007283,GO:0016020,GO:0030154,GO:0031957,GO:0035338,GO:0047617,GO:0102391 long-chain fatty acid-CoA ligase activity|ATP binding|cytoplasm|mitochondrion|cytosol|fatty acid metabolic process|multicellular organism development|spermatogenesis|membrane|cell differentiation|very long-chain fatty acid-CoA ligase activity|long-chain fatty-acyl-CoA biosynthetic process|acyl-CoA hydrolase activity|decanoate--CoA ligase activity hsa00061,hsa00071,hsa03320,hsa04920 Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Adipocytokine signaling pathway ACSF2 391.855086052207 327.727204390508 455.982967713906 1.39134915138315 0.476484501663733 0.058890166849801 0.879410748501007 2.88303 3.218 4.0751 4.72961 GeneID:80221,Genbank:NM_001288968.1,HGNC:HGNC:26101,MIM:610465 acyl-CoA synthetase family member 2 GO:0003996,GO:0005524,GO:0005759,GO:0006631,GO:0006637 acyl-CoA ligase activity|ATP binding|mitochondrial matrix|fatty acid metabolic process|acyl-CoA metabolic process ACSF3 493.505478550289 512.577124475239 474.43383262534 0.925585263117333 -0.111562200403925 0.506352909668885 1 0.755311 0.809462 0.751981 0.811382 GeneID:197322,Genbank:NM_001243279.2,HGNC:HGNC:27288,MIM:614245 acyl-CoA synthetase family member 3 GO:0005524,GO:0005739,GO:0005759,GO:0006631,GO:0006633,GO:0016878,GO:0031957,GO:0035338,GO:0090409,GO:0090410 ATP binding|mitochondrion|mitochondrial matrix|fatty acid metabolic process|fatty acid biosynthetic process|acid-thiol ligase activity|very long-chain fatty acid-CoA ligase activity|long-chain fatty-acyl-CoA biosynthetic process|malonyl-CoA synthetase activity|malonate catabolic process hsa00280 Valine, leucine and isoleucine degradation ACSL1 320.06009618779 320.260463501562 319.859728874018 0.998748722764083 -0.00180634181606081 1 1 2.06865 2.1337 2.32392 2.0253 GeneID:2180,Genbank:XM_017007887.1,HGNC:HGNC:3569,MIM:152425 acyl-CoA synthetase long chain family member 1 GO:0001676,GO:0004467,GO:0005524,GO:0005739,GO:0005741,GO:0005778,GO:0005789,GO:0005886,GO:0006641,GO:0007584,GO:0008610,GO:0014070,GO:0016020,GO:0016021,GO:0019216,GO:0033211,GO:0034201,GO:0035338,GO:0036109,GO:0042178,GO:0042493,GO:0043651,GO:0044539,GO:0071902,GO:0102391 long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|mitochondrion|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum membrane|plasma membrane|triglyceride metabolic process|response to nutrient|lipid biosynthetic process|response to organic cyclic compound|membrane|integral component of membrane|regulation of lipid metabolic process|adiponectin-activated signaling pathway|response to oleic acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|xenobiotic catabolic process|response to drug|linoleic acid metabolic process|long-chain fatty acid import|positive regulation of protein serine/threonine kinase activity|decanoate--CoA ligase activity hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920 Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSL3 1739.69248264085 1807.77895486014 1671.60601042155 0.924673896621877 -0.112983432692212 0.551862436515677 1 13.8221 11.9391 13.1917 10.543 GeneID:2181,Genbank:NM_004457.4,HGNC:HGNC:3570,MIM:602371 acyl-CoA synthetase long chain family member 3 GO:0004467,GO:0005524,GO:0005741,GO:0005778,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0006633,GO:0007420,GO:0007584,GO:0014070,GO:0016020,GO:0016021,GO:0019901,GO:0019904,GO:0034379,GO:0035338,GO:0042998,GO:0044539,GO:0048471,GO:0051047,GO:0102391,GO:2001247 long-chain fatty acid-CoA ligase activity|ATP binding|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|fatty acid biosynthetic process|brain development|response to nutrient|response to organic cyclic compound|membrane|integral component of membrane|protein kinase binding|protein domain specific binding|very-low-density lipoprotein particle assembly|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of Golgi to plasma membrane protein transport|long-chain fatty acid import|perinuclear region of cytoplasm|positive regulation of secretion|decanoate--CoA ligase activity|positive regulation of phosphatidylcholine biosynthetic process hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920 Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSL4 1350.08560295716 1495.20574631074 1204.96545960358 0.80588605452909 -0.311352226589259 0.269222621324096 1 12.1157 10.4703 11.1359 7.37 GeneID:2182,Genbank:NM_001318510.1,HGNC:HGNC:3571,MIM:300157 acyl-CoA synthetase long chain family member 4 GO:0004467,GO:0005524,GO:0005737,GO:0005741,GO:0005778,GO:0005789,GO:0005811,GO:0006629,GO:0006641,GO:0007584,GO:0008610,GO:0015908,GO:0016020,GO:0016021,GO:0030182,GO:0030307,GO:0031957,GO:0032307,GO:0035338,GO:0043025,GO:0044233,GO:0047676,GO:0060136,GO:0060996,GO:0070062,GO:0070672,GO:0102391 long-chain fatty acid-CoA ligase activity|ATP binding|cytoplasm|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum membrane|lipid droplet|lipid metabolic process|triglyceride metabolic process|response to nutrient|lipid biosynthetic process|fatty acid transport|membrane|integral component of membrane|neuron differentiation|positive regulation of cell growth|very long-chain fatty acid-CoA ligase activity|negative regulation of prostaglandin secretion|long-chain fatty-acyl-CoA biosynthetic process|neuronal cell body|ER-mitochondrion membrane contact site|arachidonate-CoA ligase activity|embryonic process involved in female pregnancy|dendritic spine development|extracellular exosome|response to interleukin-15|decanoate--CoA ligase activity hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920 Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSL5 4.4684343371114 6.51500704950053 2.42186162472226 0.371735841008481 -1.42765030216143 0.338995356252256 1 0.0209385 0.0682854 0.0099751 0.0371964 GeneID:51703,Genbank:NM_203379.1,HGNC:HGNC:16526,MIM:605677 acyl-CoA synthetase long chain family member 5 GO:0001676,GO:0004467,GO:0005524,GO:0005634,GO:0005730,GO:0005739,GO:0005741,GO:0005743,GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0035338,GO:0102391,GO:2001236 long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|nucleus|nucleolus|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|long-chain fatty-acyl-CoA biosynthetic process|decanoate--CoA ligase activity|regulation of extrinsic apoptotic signaling pathway hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920 Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSL6 11.6621139781155 15.5666150030498 7.75761295318113 0.498349381137855 -1.00477055800635 0.25181708450723 1 0.0938152 0.0638916 0.0709076 0.0179931 GeneID:23305,Genbank:NM_001205250.1,HGNC:HGNC:16496,MIM:604443 acyl-CoA synthetase long chain family member 6 GO:0001676,GO:0004467,GO:0005524,GO:0005741,GO:0005778,GO:0005789,GO:0005886,GO:0006637,GO:0016020,GO:0016021,GO:0019899,GO:0035338,GO:0042803,GO:0102391 long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|mitochondrial outer membrane|peroxisomal membrane|endoplasmic reticulum membrane|plasma membrane|acyl-CoA metabolic process|membrane|integral component of membrane|enzyme binding|long-chain fatty-acyl-CoA biosynthetic process|protein homodimerization activity|decanoate--CoA ligase activity hsa00061,hsa00071,hsa03320,hsa04146,hsa04216,hsa04714,hsa04920 Fatty acid biosynthesis|Fatty acid degradation|PPAR signaling pathway|Peroxisome|Ferroptosis|Thermogenesis|Adipocytokine signaling pathway ACSM3 7.34809128335089 11.7901226114458 2.90605995525603 0.246482589793838 -2.02044234891362 0.475769869921662 1 0.131824 0.00969062 0 0.036185 GeneID:6296,Genbank:XM_024450369.1,HGNC:HGNC:10522,MIM:145505 acyl-CoA synthetase medium chain family member 3 GO:0003996,GO:0004321,GO:0005524,GO:0005759,GO:0006633,GO:0006637,GO:0008217,GO:0015645,GO:0042632,GO:0046872,GO:0047760 acyl-CoA ligase activity|fatty-acyl-CoA synthase activity|ATP binding|mitochondrial matrix|fatty acid biosynthetic process|acyl-CoA metabolic process|regulation of blood pressure|fatty acid ligase activity|cholesterol homeostasis|metal ion binding|butyrate-CoA ligase activity hsa00650 Butanoate metabolism ACSM6 1.45346496365472 0 2.90692992730943 Inf Inf 0.254687062456722 1 0 0 0.0449617 0.0418247 GeneID:142827,Genbank:NM_207321.2,HGNC:HGNC:31665 acyl-CoA synthetase medium chain family member 6 GO:0003996,GO:0004321,GO:0005524,GO:0005525,GO:0005759,GO:0006633,GO:0006637,GO:0015645,GO:0031647,GO:0046872,GO:0047760,GO:1903955 acyl-CoA ligase activity|fatty-acyl-CoA synthase activity|ATP binding|GTP binding|mitochondrial matrix|fatty acid biosynthetic process|acyl-CoA metabolic process|fatty acid ligase activity|regulation of protein stability|metal ion binding|butyrate-CoA ligase activity|positive regulation of protein targeting to mitochondrion hsa00650 Butanoate metabolism ACSS1 104.849178570275 103.066847888499 106.631509252051 1.03458591619498 0.0490534573985907 0.885253273506633 1 0.865042 1.01588 1.16505 0.900141 GeneID:84532,Genbank:NM_001252675.1,HGNC:HGNC:16091,MIM:614355 acyl-CoA synthetase short chain family member 1 GO:0003987,GO:0005524,GO:0005759,GO:0006069,GO:0006085,GO:0016208,GO:0019413,GO:0019427,GO:0019542 acetate-CoA ligase activity|ATP binding|mitochondrial matrix|ethanol oxidation|acetyl-CoA biosynthetic process|AMP binding|acetate biosynthetic process|acetyl-CoA biosynthetic process from acetate|propionate biosynthetic process hsa00010,hsa00620,hsa00630,hsa00640 Glycolysis / Gluconeogenesis|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism ACSS2 569.445591631894 537.021842642459 601.869340621329 1.12075392997011 0.164469558267436 0.333064724723963 1 4.66778 4.78653 5.31283 5.85086 GeneID:55902,Genbank:XM_011528911.1,HGNC:HGNC:15814,MIM:605832 acyl-CoA synthetase short chain family member 2 GO:0003987,GO:0005524,GO:0005654,GO:0005737,GO:0005759,GO:0005829,GO:0006069,GO:0007005,GO:0008610,GO:0016208,GO:0019413,GO:0019427,GO:0019542,GO:0043231 acetate-CoA ligase activity|ATP binding|nucleoplasm|cytoplasm|mitochondrial matrix|cytosol|ethanol oxidation|mitochondrion organization|lipid biosynthetic process|AMP binding|acetate biosynthetic process|acetyl-CoA biosynthetic process from acetate|propionate biosynthetic process|intracellular membrane-bounded organelle hsa00010,hsa00620,hsa00630,hsa00640 Glycolysis / Gluconeogenesis|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism ACSS3 389.827179901333 385.649648369137 394.00471143353 1.02166490517942 0.0309220857974028 0.85121774989095 1 3.1331 2.79935 3.37409 2.83922 GeneID:79611,Genbank:NM_001330243.1,HGNC:HGNC:24723,MIM:614356 acyl-CoA synthetase short chain family member 3 GO:0003987,GO:0005524,GO:0005759,GO:0046951 acetate-CoA ligase activity|ATP binding|mitochondrial matrix|ketone body biosynthetic process hsa00640 Propanoate metabolism ACTA1 0.971768182806039 0.490071401957362 1.45346496365472 2.96582285326082 1.56843242909583 0.837471602739444 1 0 0.0247172 0 0.0249679 GeneID:58,Genbank:NM_001100.3,HGNC:HGNC:129,MIM:102610 actin, alpha 1, skeletal muscle GO:0001725,GO:0005524,GO:0005865,GO:0005884,GO:0030240,GO:0048741 stress fiber|ATP binding|striated muscle thin filament|actin filament|skeletal muscle thin filament assembly|skeletal muscle fiber development ACTA2 244.832918559798 192.085321254506 297.580515865091 1.54921007977912 0.631532793259197 0.00319334415436531 0.212218257163132 3.01804 3.11265 5.49402 4.45907 GeneID:59,Genbank:NM_001320855.1,HGNC:HGNC:130,MIM:102620 actin, alpha 2, smooth muscle, aorta GO:0001725,GO:0005524,GO:0005615,GO:0005737,GO:0005856,GO:0006936,GO:0008217,GO:0009615,GO:0010628,GO:0014829,GO:0015629,GO:0019901,GO:0030027,GO:0030175,GO:0030485,GO:0043234,GO:0044297,GO:0061041,GO:0061870,GO:0061874,GO:0070062,GO:0070374,GO:0072144,GO:0090131,GO:2000491 stress fiber|ATP binding|extracellular space|cytoplasm|cytoskeleton|muscle contraction|regulation of blood pressure|response to virus|positive regulation of gene expression|vascular smooth muscle contraction|actin cytoskeleton|protein kinase binding|lamellipodium|filopodium|smooth muscle contractile fiber|protein complex|cell body|regulation of wound healing|positive regulation of hepatic stellate cell migration|positive regulation of hepatic stellate cell contraction|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|glomerular mesangial cell development|mesenchyme migration|positive regulation of hepatic stellate cell activation hsa04270,hsa04371,hsa04926 Vascular smooth muscle contraction|Apelin signaling pathway|Relaxin signaling pathway ACTB 176718.032641762 169691.077605778 183744.987677746 1.08282055998618 0.114794186005463 0.378107842656706 1 3713.42 3729.54 4174.2 4080.55 GeneID:60,Genbank:NM_001101.4,HGNC:HGNC:132,MIM:102630 actin beta GO:0000790,GO:0001725,GO:0001895,GO:0002102,GO:0005524,GO:0005615,GO:0005634,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0007409,GO:0007623,GO:0009612,GO:0014069,GO:0015629,GO:0016020,GO:0019894,GO:0019901,GO:0021762,GO:0030424,GO:0030529,GO:0030863,GO:0030957,GO:0031982,GO:0032091,GO:0035267,GO:0035902,GO:0036464,GO:0042802,GO:0043044,GO:0043209,GO:0043234,GO:0045121,GO:0050998,GO:0060041,GO:0070062,GO:0070527,GO:0071257,GO:0072562,GO:0097433,GO:0098973,GO:0098974 nuclear chromatin|stress fiber|retina homeostasis|podosome|ATP binding|extracellular space|nucleus|cytosol|cytoskeleton|plasma membrane|focal adhesion|axonogenesis|circadian rhythm|response to mechanical stimulus|postsynaptic density|actin cytoskeleton|membrane|kinesin binding|protein kinase binding|substantia nigra development|axon|intracellular ribonucleoprotein complex|cortical cytoskeleton|Tat protein binding|vesicle|negative regulation of protein binding|NuA4 histone acetyltransferase complex|response to immobilization stress|cytoplasmic ribonucleoprotein granule|identical protein binding|ATP-dependent chromatin remodeling|myelin sheath|protein complex|membrane raft|nitric-oxide synthase binding|retina development in camera-type eye|extracellular exosome|platelet aggregation|cellular response to electrical stimulus|blood microparticle|dense body|structural constituent of postsynaptic actin cytoskeleton|postsynaptic actin cytoskeleton organization hsa04015,hsa04145,hsa04210,hsa04390,hsa04510,hsa04520,hsa04530,hsa04611,hsa04670,hsa04714,hsa04810,hsa04919,hsa04921,hsa04971,hsa05100,hsa05110,hsa05130,hsa05131,hsa05132,hsa05164,hsa05205,hsa05225,hsa05410,hsa05412,hsa05414,hsa05416,hsa05418 Rap1 signaling pathway|Phagosome|Apoptosis|Hippo signaling pathway|Focal adhesion|Adherens junction|Tight junction|Platelet activation|Leukocyte transendothelial migration|Thermogenesis|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Gastric acid secretion|Bacterial invasion of epithelial cells|Vibrio cholerae infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Influenza A|Proteoglycans in cancer|Hepatocellular carcinoma|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Viral myocarditis|Fluid shear stress and atherosclerosis ACTC1 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0227398 0.0116638 0 GeneID:70,Genbank:NM_005159.4,HGNC:HGNC:143,MIM:102540 actin, alpha, cardiac muscle 1 GO:0005524,GO:0005615,GO:0005737,GO:0005884,GO:0005925,GO:0010628,GO:0016020,GO:0016887,GO:0017022,GO:0030017,GO:0030027,GO:0030048,GO:0030175,GO:0030240,GO:0031032,GO:0031674,GO:0033275,GO:0042493,GO:0042643,GO:0043066,GO:0044297,GO:0045471,GO:0055003,GO:0055008,GO:0060047,GO:0060048,GO:0070062,GO:0070252,GO:0072562,GO:0090131 ATP binding|extracellular space|cytoplasm|actin filament|focal adhesion|positive regulation of gene expression|membrane|ATPase activity|myosin binding|sarcomere|lamellipodium|actin filament-based movement|filopodium|skeletal muscle thin filament assembly|actomyosin structure organization|I band|actin-myosin filament sliding|response to drug|actomyosin, actin portion|negative regulation of apoptotic process|cell body|response to ethanol|cardiac myofibril assembly|cardiac muscle tissue morphogenesis|heart contraction|cardiac muscle contraction|extracellular exosome|actin-mediated cell contraction|blood microparticle|mesenchyme migration hsa04260,hsa04261,hsa05410,hsa05414 Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) ACTG1 115243.118643591 123564.420082988 106921.817204194 0.865312337745631 -0.208707121926937 0.129973749145053 1 2271.51 2373.25 1925.27 2171.94 GeneID:71,Genbank:NM_001614.3,HGNC:HGNC:144,MIM:102560 actin gamma 1 GO:0001895,GO:0005200,GO:0005522,GO:0005524,GO:0005615,GO:0005634,GO:0005829,GO:0005856,GO:0005884,GO:0005886,GO:0005925,GO:0009612,GO:0015629,GO:0016020,GO:0030016,GO:0031012,GO:0031625,GO:0031941,GO:0042802,GO:0043209,GO:0045214,GO:0045335,GO:0051592,GO:0070062,GO:0070527,GO:0071346,GO:0072562,GO:0097433 retina homeostasis|structural constituent of cytoskeleton|profilin binding|ATP binding|extracellular space|nucleus|cytosol|cytoskeleton|actin filament|plasma membrane|focal adhesion|response to mechanical stimulus|actin cytoskeleton|membrane|myofibril|extracellular matrix|ubiquitin protein ligase binding|filamentous actin|identical protein binding|myelin sheath|sarcomere organization|phagocytic vesicle|response to calcium ion|extracellular exosome|platelet aggregation|cellular response to interferon-gamma|blood microparticle|dense body hsa04015,hsa04145,hsa04210,hsa04390,hsa04510,hsa04520,hsa04530,hsa04611,hsa04670,hsa04714,hsa04810,hsa04919,hsa04921,hsa05100,hsa05110,hsa05130,hsa05131,hsa05132,hsa05164,hsa05205,hsa05225,hsa05410,hsa05412,hsa05414,hsa05416,hsa05418 Rap1 signaling pathway|Phagosome|Apoptosis|Hippo signaling pathway|Focal adhesion|Adherens junction|Tight junction|Platelet activation|Leukocyte transendothelial migration|Thermogenesis|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Bacterial invasion of epithelial cells|Vibrio cholerae infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Influenza A|Proteoglycans in cancer|Hepatocellular carcinoma|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Viral myocarditis|Fluid shear stress and atherosclerosis ACTG2 17.3085480166351 21.0534529739507 13.5636430593194 0.644247909172031 -0.634312144885566 0.367832123739575 1 0.632786 0.506237 0.207545 0.550137 GeneID:72,Genbank:NM_001615.3,HGNC:HGNC:145,MIM:102545 actin, gamma 2, smooth muscle, enteric GO:0005524,GO:0005615,GO:0005737,GO:0010628,GO:0030027,GO:0030175,GO:0032982,GO:0044297,GO:0070062,GO:0071944,GO:0072562,GO:0090131 ATP binding|extracellular space|cytoplasm|positive regulation of gene expression|lamellipodium|filopodium|myosin filament|cell body|extracellular exosome|cell periphery|blood microparticle|mesenchyme migration hsa04270 Vascular smooth muscle contraction ACTL10 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:170487,Genbank:NM_001024675.1,HGNC:HGNC:16127 actin like 10 ACTL6A 2475.33315012319 2553.2614057764 2397.40489446998 0.93895787131164 -0.0908676656699233 0.523405176057424 1 48.7643 46.5962 45.1122 45.2493 GeneID:86,Genbank:NM_178042.3,HGNC:HGNC:24124,MIM:604958 actin like 6A GO:0000790,GO:0003407,GO:0003682,GO:0003713,GO:0005634,GO:0005654,GO:0005886,GO:0006281,GO:0006310,GO:0006338,GO:0006351,GO:0006357,GO:0007165,GO:0016514,GO:0016579,GO:0021510,GO:0031011,GO:0035267,GO:0040008,GO:0043044,GO:0043234,GO:0043967,GO:0043968,GO:0071564,GO:1903146,GO:1903955 nuclear chromatin|neural retina development|chromatin binding|transcription coactivator activity|nucleus|nucleoplasm|plasma membrane|DNA repair|DNA recombination|chromatin remodeling|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|signal transduction|SWI/SNF complex|protein deubiquitination|spinal cord development|Ino80 complex|NuA4 histone acetyltransferase complex|regulation of growth|ATP-dependent chromatin remodeling|protein complex|histone H4 acetylation|histone H2A acetylation|npBAF complex|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma ACTL6B 1.02229600717608 1.07619535328461 0.968396661067546 0.899833527539349 -0.152269972565186 1 1 0 0 0 0.0461555 GeneID:51412,Genbank:NM_016188.4,HGNC:HGNC:160,MIM:612458 actin like 6B GO:0003713,GO:0005200,GO:0005634,GO:0005730,GO:0006325,GO:0006338,GO:0006351,GO:0006357,GO:0016514,GO:0016569,GO:0021510,GO:0071565 transcription coactivator activity|structural constituent of cytoskeleton|nucleus|nucleolus|chromatin organization|chromatin remodeling|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|SWI/SNF complex|covalent chromatin modification|spinal cord development|nBAF complex hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma ACTL8 3.42264604424096 1.51824048055703 5.3270516079249 3.50870081264758 1.81093693420006 0.470260592906803 1 0.0297957 0.0526689 0.0277917 0.233185 GeneID:81569,Genbank:NM_030812.2,HGNC:HGNC:24018 actin like 8 GO:0005737,GO:0005856,GO:0030855 cytoplasm|cytoskeleton|epithelial cell differentiation ACTN1 9838.93756483321 9874.62752112317 9803.24760854324 0.992771381763288 -0.0104665668317294 0.922166196046861 1 51.6124 53.5058 52.8959 53.4065 GeneID:87,Genbank:NM_001130005.1,HGNC:HGNC:163,MIM:102575 actinin alpha 1 GO:0001725,GO:0001726,GO:0002576,GO:0003725,GO:0005178,GO:0005509,GO:0005576,GO:0005615,GO:0005622,GO:0005737,GO:0005829,GO:0005886,GO:0005903,GO:0005911,GO:0005916,GO:0005925,GO:0007015,GO:0017166,GO:0030018,GO:0030220,GO:0030374,GO:0031093,GO:0031143,GO:0036344,GO:0042803,GO:0042981,GO:0042995,GO:0044325,GO:0048041,GO:0051015,GO:0051017,GO:0051271,GO:0051639,GO:0051764,GO:0070062 stress fiber|ruffle|platelet degranulation|double-stranded RNA binding|integrin binding|calcium ion binding|extracellular region|extracellular space|intracellular|cytoplasm|cytosol|plasma membrane|brush border|cell-cell junction|fascia adherens|focal adhesion|actin filament organization|vinculin binding|Z disc|platelet formation|ligand-dependent nuclear receptor transcription coactivator activity|platelet alpha granule lumen|pseudopodium|platelet morphogenesis|protein homodimerization activity|regulation of apoptotic process|cell projection|ion channel binding|focal adhesion assembly|actin filament binding|actin filament bundle assembly|negative regulation of cellular component movement|actin filament network formation|actin crosslink formation|extracellular exosome hsa04510,hsa04520,hsa04530,hsa04670,hsa04810,hsa05146,hsa05203,hsa05322 Focal adhesion|Adherens junction|Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Amoebiasis|Viral carcinogenesis|Systemic lupus erythematosus ACTN2 5.06813024101403 5.77499561901052 4.36126486301754 0.755197951780403 -0.405073243005753 0.852213770127435 1 0.0644825 0.0222932 0.0306407 0.021332 GeneID:88,Genbank:NM_001278344.1,HGNC:HGNC:164,MIM:102573 actinin alpha 2 GO:0000165,GO:0002576,GO:0005088,GO:0005178,GO:0005509,GO:0005546,GO:0005576,GO:0005829,GO:0005856,GO:0005884,GO:0005925,GO:0007155,GO:0008092,GO:0008307,GO:0019904,GO:0030018,GO:0030035,GO:0030049,GO:0030175,GO:0030274,GO:0030375,GO:0030864,GO:0031093,GO:0031143,GO:0031432,GO:0042391,GO:0042802,GO:0042803,GO:0042981,GO:0043197,GO:0043267,GO:0043268,GO:0044325,GO:0045214,GO:0046983,GO:0048041,GO:0051015,GO:0051289,GO:0051373,GO:0051695,GO:0055013,GO:0070062,GO:0070080,GO:0072659,GO:0086097,GO:1901017,GO:1901018,GO:2000009,GO:2001137,GO:2001259 MAPK cascade|platelet degranulation|Ras guanyl-nucleotide exchange factor activity|integrin binding|calcium ion binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|cytosol|cytoskeleton|actin filament|focal adhesion|cell adhesion|cytoskeletal protein binding|structural constituent of muscle|protein domain specific binding|Z disc|microspike assembly|muscle filament sliding|filopodium|LIM domain binding|thyroid hormone receptor coactivator activity|cortical actin cytoskeleton|platelet alpha granule lumen|pseudopodium|titin binding|regulation of membrane potential|identical protein binding|protein homodimerization activity|regulation of apoptotic process|dendritic spine|negative regulation of potassium ion transport|positive regulation of potassium ion transport|ion channel binding|sarcomere organization|protein dimerization activity|focal adhesion assembly|actin filament binding|protein homotetramerization|FATZ binding|actin filament uncapping|cardiac muscle cell development|extracellular exosome|titin Z domain binding|protein localization to plasma membrane|phospholipase C-activating angiotensin-activated signaling pathway|negative regulation of potassium ion transmembrane transporter activity|positive regulation of potassium ion transmembrane transporter activity|negative regulation of protein localization to cell surface|positive regulation of endocytic recycling|positive regulation of cation channel activity hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) ACTN4 43427.1757833099 42635.4387553469 44218.912811273 1.03713985600131 0.0526104514846218 0.699065839168366 1 295.52 309.687 320.762 321.574 GeneID:81,Genbank:NM_004924.5,HGNC:HGNC:166,MIM:604638 actinin alpha 4 GO:0000977,GO:0001666,GO:0001725,GO:0001882,GO:0002576,GO:0003723,GO:0003779,GO:0005178,GO:0005509,GO:0005576,GO:0005615,GO:0005622,GO:0005634,GO:0005737,GO:0005829,GO:0005903,GO:0005911,GO:0005925,GO:0015031,GO:0016604,GO:0030018,GO:0030050,GO:0030335,GO:0030374,GO:0030529,GO:0030863,GO:0031093,GO:0031143,GO:0031490,GO:0032417,GO:0035257,GO:0035357,GO:0042803,GO:0042974,GO:0042981,GO:0043005,GO:0043234,GO:0044325,GO:0047485,GO:0048384,GO:0048471,GO:0048549,GO:0051015,GO:0051017,GO:0051271,GO:0051272,GO:0070062,GO:0070830,GO:1900025,GO:1901224,GO:1902396,GO:1903506 RNA polymerase II regulatory region sequence-specific DNA binding|response to hypoxia|stress fiber|nucleoside binding|platelet degranulation|RNA binding|actin binding|integrin binding|calcium ion binding|extracellular region|extracellular space|intracellular|nucleus|cytoplasm|cytosol|brush border|cell-cell junction|focal adhesion|protein transport|nuclear body|Z disc|vesicle transport along actin filament|positive regulation of cell migration|ligand-dependent nuclear receptor transcription coactivator activity|intracellular ribonucleoprotein complex|cortical cytoskeleton|platelet alpha granule lumen|pseudopodium|chromatin DNA binding|positive regulation of sodium:proton antiporter activity|nuclear hormone receptor binding|peroxisome proliferator activated receptor signaling pathway|protein homodimerization activity|retinoic acid receptor binding|regulation of apoptotic process|neuron projection|protein complex|ion channel binding|protein N-terminus binding|retinoic acid receptor signaling pathway|perinuclear region of cytoplasm|positive regulation of pinocytosis|actin filament binding|actin filament bundle assembly|negative regulation of cellular component movement|positive regulation of cellular component movement|extracellular exosome|bicellular tight junction assembly|negative regulation of substrate adhesion-dependent cell spreading|positive regulation of NIK/NF-kappaB signaling|protein localization to bicellular tight junction|regulation of nucleic acid-templated transcription hsa04510,hsa04520,hsa04530,hsa04670,hsa04810,hsa05146,hsa05203,hsa05322 Focal adhesion|Adherens junction|Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Amoebiasis|Viral carcinogenesis|Systemic lupus erythematosus ACTR10 1143.97803797266 1209.69436007517 1078.26171587014 0.891350535686661 -0.165935192159351 0.272460752649524 1 19.3143 19.1166 16.7588 17.7794 GeneID:55860,Genbank:NM_018477.2,HGNC:HGNC:17372 actin related protein 10 homolog GO:0005576,GO:0005829,GO:0005869,GO:0006888,GO:0007018,GO:0019886,GO:0035578,GO:0043312,GO:1904813 extracellular region|cytosol|dynactin complex|ER to Golgi vesicle-mediated transport|microtubule-based movement|antigen processing and presentation of exogenous peptide antigen via MHC class II|azurophil granule lumen|neutrophil degranulation|ficolin-1-rich granule lumen ACTR1A 6547.8043533943 6382.73769712951 6712.8710096591 1.05172283872453 0.0727545602570066 0.588448743219996 1 80.5271 82.3074 87.8735 88.4839 GeneID:10121,Genbank:NM_005736.3,HGNC:HGNC:167,MIM:605143 ARP1 actin related protein 1 homolog A GO:0005524,GO:0005737,GO:0005813,GO:0005869,GO:0043209,GO:0099738 ATP binding|cytoplasm|centrosome|dynactin complex|myelin sheath|cell cortex region ACTR1B 995.050514293977 904.608526725784 1085.49250186217 1.19995829111969 0.26298426063334 0.161211278185819 1 14.0864 15.924 17.7582 19.6097 GeneID:10120,Genbank:NM_005735.3,HGNC:HGNC:168,MIM:605144 ARP1 actin related protein 1 homolog B GO:0005524,GO:0005576,GO:0005737,GO:0005813,GO:0005829,GO:0005869,GO:0015630,GO:0016020,GO:0019886,GO:0034774,GO:0043312,GO:0070062,GO:1904813 ATP binding|extracellular region|cytoplasm|centrosome|cytosol|dynactin complex|microtubule cytoskeleton|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|secretory granule lumen|neutrophil degranulation|extracellular exosome|ficolin-1-rich granule lumen ACTR2 3860.66316763519 4139.12527644498 3582.2010588254 0.865448813354614 -0.208479600429167 0.327681818897128 1 46.1986 39.0044 41.3736 32.6724 GeneID:10097,Genbank:NM_001005386.2,HGNC:HGNC:169,MIM:604221 ARP2 actin related protein 2 homolog GO:0003779,GO:0005200,GO:0005524,GO:0005576,GO:0005737,GO:0005829,GO:0005885,GO:0005925,GO:0006928,GO:0007163,GO:0008306,GO:0008356,GO:0014069,GO:0015629,GO:0016020,GO:0016344,GO:0016482,GO:0030027,GO:0030478,GO:0033206,GO:0034314,GO:0035578,GO:0035902,GO:0035984,GO:0038096,GO:0043312,GO:0045471,GO:0048013,GO:0051653,GO:0060271,GO:0061003,GO:0061024,GO:0061825,GO:0070062,GO:0071346,GO:0071437,GO:1904813 actin binding|structural constituent of cytoskeleton|ATP binding|extracellular region|cytoplasm|cytosol|Arp2/3 protein complex|focal adhesion|movement of cell or subcellular component|establishment or maintenance of cell polarity|associative learning|asymmetric cell division|postsynaptic density|actin cytoskeleton|membrane|meiotic chromosome movement towards spindle pole|cytosolic transport|lamellipodium|actin cap|meiotic cytokinesis|Arp2/3 complex-mediated actin nucleation|azurophil granule lumen|response to immobilization stress|cellular response to trichostatin A|Fc-gamma receptor signaling pathway involved in phagocytosis|neutrophil degranulation|response to ethanol|ephrin receptor signaling pathway|spindle localization|cilium assembly|positive regulation of dendritic spine morphogenesis|membrane organization|podosome core|extracellular exosome|cellular response to interferon-gamma|invadopodium|ficolin-1-rich granule lumen hsa04530 Tight junction ACTR3 4863.8334375156 5100.7555905872 4626.911284444 0.907103114876232 -0.140661536564731 0.303507324815115 1 38.9709 37.3151 37.1153 32.7486 GeneID:10096,Genbank:NM_005721.4,HGNC:HGNC:170,MIM:604222 ARP3 actin related protein 3 homolog GO:0003779,GO:0005524,GO:0005829,GO:0005885,GO:0034314,GO:0042995,GO:0060271 actin binding|ATP binding|cytosol|Arp2/3 protein complex|Arp2/3 complex-mediated actin nucleation|cell projection|cilium assembly hsa04530 Tight junction ACTR3B 272.536761268026 310.02679899025 235.046723545802 0.758149696449932 -0.399445358623837 0.0529122467544591 0.840383088256616 1.44339 1.26995 1.09406 1.08034 GeneID:57180,Genbank:NM_001350942.1,HGNC:HGNC:17256 ARP3 actin related protein 3 homolog B GO:0003779,GO:0005524,GO:0005737,GO:0005885,GO:0034314,GO:0042995,GO:0070062 actin binding|ATP binding|cytoplasm|Arp2/3 protein complex|Arp2/3 complex-mediated actin nucleation|cell projection|extracellular exosome hsa04530 Tight junction ACTR3C 3.40037285100529 1.47021420587209 5.33053149613849 3.62568357375963 1.85825302147267 0.335623084440636 1 0 0.00451202 0.00607537 0.00707519 GeneID:653857,Genbank:NM_001351028.1,HGNC:HGNC:37282 ARP3 actin related protein 3 homolog C GO:0003779,GO:0005524,GO:0005885,GO:0034314,GO:0070062 actin binding|ATP binding|Arp2/3 protein complex|Arp2/3 complex-mediated actin nucleation|extracellular exosome hsa04530 Tight junction ACTR5 253.609109562781 276.059001776884 231.159217348677 0.837354391129418 -0.256089755126988 0.221176064424435 1 4.2587 4.54378 3.5059 3.83273 GeneID:79913,Genbank:NM_024855.3,HGNC:HGNC:14671 ARP5 actin related protein 5 homolog GO:0005634,GO:0005654,GO:0005737,GO:0006302,GO:0006310,GO:0006351,GO:0006355,GO:0016579,GO:0031011,GO:0070914 nucleus|nucleoplasm|cytoplasm|double-strand break repair|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|protein deubiquitination|Ino80 complex|UV-damage excision repair ACTR6 330.662937575927 387.043427335855 274.282447815999 0.708660652640386 -0.496833147186156 0.0107342796521543 0.413666579021508 6.04829 5.96698 4.12815 4.43446 GeneID:64431,Genbank:NM_022496.4,HGNC:HGNC:24025 ARP6 actin related protein 6 homolog GO:0005634,GO:0005737,GO:0005856,GO:0006338 nucleus|cytoplasm|cytoskeleton|chromatin remodeling ACTR8 1067.3316745777 1116.86117669799 1017.80217245742 0.911305893420494 -0.133992697450376 0.381611781991492 1 3.65705 3.52264 3.69071 2.93742 GeneID:93973,Genbank:XM_011534249.3,HGNC:HGNC:14672 ARP8 actin related protein 8 homolog GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0006281,GO:0006310,GO:0006338,GO:0006351,GO:0006355,GO:0007049,GO:0016579,GO:0031011,GO:0051301 ATP binding|nucleus|nucleoplasm|centrosome|DNA repair|DNA recombination|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|protein deubiquitination|Ino80 complex|cell division ACVR1 681.393099943691 676.478435789642 686.307764097739 1.01453014285167 0.0208117298521774 0.910651264034549 1 4.5414 4.90117 5.57558 4.21662 GeneID:90,Genbank:XM_006712825.4,HGNC:HGNC:171,MIM:102576 activin A receptor type 1 GO:0000082,GO:0001569,GO:0001701,GO:0001702,GO:0001707,GO:0001755,GO:0002526,GO:0003143,GO:0003181,GO:0003183,GO:0003203,GO:0003274,GO:0003289,GO:0004672,GO:0004674,GO:0004675,GO:0004702,GO:0005025,GO:0005524,GO:0005887,GO:0006468,GO:0007179,GO:0007281,GO:0007368,GO:0009968,GO:0010862,GO:0016361,GO:0017046,GO:0018107,GO:0030278,GO:0030335,GO:0030501,GO:0030509,GO:0032924,GO:0032926,GO:0042803,GO:0045177,GO:0045669,GO:0045893,GO:0045944,GO:0046332,GO:0046872,GO:0048179,GO:0048185,GO:0050431,GO:0051145,GO:0060037,GO:0060389,GO:0060412,GO:0060923,GO:0061312,GO:0061445,GO:0071773,GO:1905007,GO:2000017,GO:2001237 G1/S transition of mitotic cell cycle|branching involved in blood vessel morphogenesis|in utero embryonic development|gastrulation with mouth forming second|mesoderm formation|neural crest cell migration|acute inflammatory response|embryonic heart tube morphogenesis|atrioventricular valve morphogenesis|mitral valve morphogenesis|endocardial cushion morphogenesis|endocardial cushion fusion|atrial septum primum morphogenesis|protein kinase activity|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|signal transducer, downstream of receptor, with serine/threonine kinase activity|transforming growth factor beta receptor activity, type I|ATP binding|integral component of plasma membrane|protein phosphorylation|transforming growth factor beta receptor signaling pathway|germ cell development|determination of left/right symmetry|negative regulation of signal transduction|positive regulation of pathway-restricted SMAD protein phosphorylation|activin receptor activity, type I|peptide hormone binding|peptidyl-threonine phosphorylation|regulation of ossification|positive regulation of cell migration|positive regulation of bone mineralization|BMP signaling pathway|activin receptor signaling pathway|negative regulation of activin receptor signaling pathway|protein homodimerization activity|apical part of cell|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|SMAD binding|metal ion binding|activin receptor complex|activin binding|transforming growth factor beta binding|smooth muscle cell differentiation|pharyngeal system development|pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|cardiac muscle cell fate commitment|BMP signaling pathway involved in heart development|endocardial cushion cell fate commitment|cellular response to BMP stimulus|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of determination of dorsal identity|negative regulation of extrinsic apoptotic signaling pathway hsa04060,hsa04350,hsa04550,hsa05418 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis ACVR1B 377.630273986933 399.535343758214 355.725204215653 0.890347274084785 -0.167559935348437 0.372319325533738 1 2.76336 2.85631 2.74599 2.34407 GeneID:91,Genbank:NM_020328.3,HGNC:HGNC:172,MIM:601300 activin A receptor type 1B GO:0000082,GO:0001701,GO:0001942,GO:0004674,GO:0004675,GO:0004702,GO:0005524,GO:0005829,GO:0005886,GO:0005887,GO:0006355,GO:0006468,GO:0007165,GO:0007178,GO:0007417,GO:0009986,GO:0010629,GO:0010862,GO:0016361,GO:0018107,GO:0030308,GO:0031625,GO:0032924,GO:0032927,GO:0034711,GO:0038092,GO:0043235,GO:0045648,GO:0045944,GO:0046332,GO:0046545,GO:0046777,GO:0046872,GO:0048179,GO:0048185,GO:0070062,GO:0097191,GO:1901165 G1/S transition of mitotic cell cycle|in utero embryonic development|hair follicle development|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|signal transducer, downstream of receptor, with serine/threonine kinase activity|ATP binding|cytosol|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|protein phosphorylation|signal transduction|transmembrane receptor protein serine/threonine kinase signaling pathway|central nervous system development|cell surface|negative regulation of gene expression|positive regulation of pathway-restricted SMAD protein phosphorylation|activin receptor activity, type I|peptidyl-threonine phosphorylation|negative regulation of cell growth|ubiquitin protein ligase binding|activin receptor signaling pathway|positive regulation of activin receptor signaling pathway|inhibin binding|nodal signaling pathway|receptor complex|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|SMAD binding|development of primary female sexual characteristics|protein autophosphorylation|metal ion binding|activin receptor complex|activin binding|extracellular exosome|extrinsic apoptotic signaling pathway|positive regulation of trophoblast cell migration hsa04060,hsa04350,hsa04550 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells ACVR1C 9.40279455138259 9.10944288334217 9.69614621942302 1.06440606122617 0.0900486308767932 1 1 0.0336103 0.0607509 0.0708201 0.0202688 GeneID:130399,Genbank:NM_001111033.1,HGNC:HGNC:18123,MIM:608981 activin A receptor type 1C GO:0002021,GO:0004674,GO:0004702,GO:0005524,GO:0005886,GO:0006468,GO:0009749,GO:0016361,GO:0019838,GO:0019915,GO:0030154,GO:0030262,GO:0032868,GO:0038092,GO:0038100,GO:0043280,GO:0046676,GO:0046872,GO:0048179,GO:1901164,GO:1901383 response to dietary excess|protein serine/threonine kinase activity|signal transducer, downstream of receptor, with serine/threonine kinase activity|ATP binding|plasma membrane|protein phosphorylation|response to glucose|activin receptor activity, type I|growth factor binding|lipid storage|cell differentiation|apoptotic nuclear changes|response to insulin|nodal signaling pathway|nodal binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of insulin secretion|metal ion binding|activin receptor complex|negative regulation of trophoblast cell migration|negative regulation of chorionic trophoblast cell proliferation hsa04060,hsa04350,hsa04550 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells ACVR2A 70.6471924175445 68.1090992161106 73.1852856189783 1.07453022373356 0.103706062586342 0.788426218976436 1 0.442996 0.523967 0.599334 0.509072 GeneID:92,Genbank:NM_001278579.1,HGNC:HGNC:173,MIM:102581 activin A receptor type 2A hsa04060,hsa04350,hsa04550,hsa05418 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis ACVR2B 104.291516388374 102.912960409337 105.670072367411 1.02679071661245 0.0381421574364367 0.912997359530776 1 0.252493 0.227014 0.301584 0.180501 GeneID:93,Genbank:NM_001106.3,HGNC:HGNC:174,MIM:602730 activin A receptor type 2B GO:0000122,GO:0001702,GO:0001822,GO:0001946,GO:0001974,GO:0004674,GO:0004675,GO:0004702,GO:0004712,GO:0005524,GO:0005737,GO:0005886,GO:0005887,GO:0006355,GO:0007165,GO:0007178,GO:0007368,GO:0007498,GO:0007507,GO:0009749,GO:0009791,GO:0009952,GO:0019838,GO:0030073,GO:0030324,GO:0030501,GO:0030509,GO:0031016,GO:0032147,GO:0032924,GO:0032927,GO:0035265,GO:0042475,GO:0043234,GO:0043235,GO:0045669,GO:0046872,GO:0048185,GO:0048617,GO:0048705,GO:0060021,GO:0060836,GO:0060840,GO:0060841,GO:0061298 negative regulation of transcription from RNA polymerase II promoter|gastrulation with mouth forming second|kidney development|lymphangiogenesis|blood vessel remodeling|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|signal transducer, downstream of receptor, with serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|ATP binding|cytoplasm|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|signal transduction|transmembrane receptor protein serine/threonine kinase signaling pathway|determination of left/right symmetry|mesoderm development|heart development|response to glucose|post-embryonic development|anterior/posterior pattern specification|growth factor binding|insulin secretion|lung development|positive regulation of bone mineralization|BMP signaling pathway|pancreas development|activation of protein kinase activity|activin receptor signaling pathway|positive regulation of activin receptor signaling pathway|organ growth|odontogenesis of dentin-containing tooth|protein complex|receptor complex|positive regulation of osteoblast differentiation|metal ion binding|activin binding|embryonic foregut morphogenesis|skeletal system morphogenesis|palate development|lymphatic endothelial cell differentiation|artery development|venous blood vessel development|retina vasculature development in camera-type eye hsa04060,hsa04350,hsa04550,hsa05418 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis ACVRL1 1.2378804854154 0.538097676642304 1.93766329418849 3.60095086505369 1.84837791409998 0.680650629779701 1 0.0107192 0 0.00996319 0.0279212 GeneID:94,Genbank:XM_005269235.2,HGNC:HGNC:175,MIM:601284 activin A receptor like type 1 hsa04060 Cytokine-cytokine receptor interaction ACY1 6.4794420014074 6.65908587355536 6.29979812925943 0.946045485654009 -0.0800185452022892 1 1 11.045 10.6627 12.846 12.4017 GeneID:95,Genbank:NM_000666.2,HGNC:HGNC:177,MIM:104620 aminoacylase 1 GO:0004046,GO:0005829,GO:0006520,GO:0006805,GO:0008237,GO:0042802,GO:0046872,GO:0070062 aminoacylase activity|cytosol|cellular amino acid metabolic process|xenobiotic metabolic process|metallopeptidase activity|identical protein binding|metal ion binding|extracellular exosome hsa00220 Arginine biosynthesis ACYP1 254.120309545068 266.459487491584 241.781131598551 0.907384210165111 -0.140214540019833 0.668406245191601 1 13.0634 13.1441 9.6516 14.8235 GeneID:97,Genbank:NM_001302617.1,HGNC:HGNC:179,MIM:600875 acylphosphatase 1 GO:0003998,GO:0006796,GO:0070062 acylphosphatase activity|phosphate-containing compound metabolic process|extracellular exosome hsa00620 Pyruvate metabolism ACYP2 132.113777343435 126.118804089856 138.108750597014 1.09506866635537 0.131021336953736 0.618011308836926 1 0.475175 0.41812 0.52691 0.561835 GeneID:98,Genbank:XM_017005413.1,HGNC:HGNC:180,MIM:102595 acylphosphatase 2 GO:0003998,GO:0006796,GO:0042802 acylphosphatase activity|phosphate-containing compound metabolic process|identical protein binding hsa00620 Pyruvate metabolism ADA 81.4131055550549 94.01523993495 68.8109711751598 0.731912945420026 -0.450256032005941 0.161835739450588 1 1.79504 1.98593 1.31404 1.41242 GeneID:100,Genbank:NM_001322050.1,HGNC:HGNC:186,MIM:608958 adenosine deaminase hsa00230,hsa05340 Purine metabolism|Primary immunodeficiency ADAL 418.010234005324 392.059811215014 443.960656795635 1.1323799177982 0.179358069095033 0.336216604253411 1 2.45777 2.87919 3.45163 2.58934 GeneID:161823,Genbank:XM_024449859.1,HGNC:HGNC:31853 adenosine deaminase like GO:0004000,GO:0005829,GO:0006154,GO:0009117,GO:0017144,GO:0043101,GO:0046103,GO:0046872 adenosine deaminase activity|cytosol|adenosine catabolic process|nucleotide metabolic process|drug metabolic process|purine-containing compound salvage|inosine biosynthetic process|metal ion binding ADAM10 980.487126602475 1072.53220245691 888.442050748046 0.828359324515241 -0.271671381214118 0.365273825584623 1 8.29528 6.57507 7.22434 5.16995 GeneID:102,Genbank:NM_001320570.1,HGNC:HGNC:188,MIM:602192 ADAM metallopeptidase domain 10 hsa05010,hsa05120 Alzheimer disease|Epithelial cell signaling in Helicobacter pylori infection ADAM11 34.2217448900866 29.6728244553355 38.7706653248377 1.30660515257645 0.385823234107648 0.443712027881352 1 0.218945 0.238341 0.316768 0.296891 GeneID:4185,Genbank:XM_005257373.4,HGNC:HGNC:189,MIM:155120 ADAM metallopeptidase domain 11 GO:0004222,GO:0005178,GO:0005886,GO:0007229,GO:0008237,GO:0016021 metalloendopeptidase activity|integrin binding|plasma membrane|integrin-mediated signaling pathway|metallopeptidase activity|integral component of membrane ADAM12 6447.03226800929 6685.72694070042 6208.33759531817 0.928595745890239 -0.106877423284009 0.529425739521656 1 19.334 19.1189 20.5265 15.062 GeneID:8038,Genbank:NM_001288973.1,HGNC:HGNC:190,MIM:602714 ADAM metallopeptidase domain 12 ADAM15 2471.75467107013 1820.74539337766 3122.7639487626 1.71510193578991 0.778294324437878 2.32016483820245e-08 2.65426857490361e-05 18.7751 18.311 31.2713 32.8772 GeneID:8751,Genbank:NM_001261464.1,HGNC:HGNC:193,MIM:605548 ADAM metallopeptidase domain 15 GO:0001525,GO:0001669,GO:0001953,GO:0002418,GO:0004222,GO:0005178,GO:0005886,GO:0005912,GO:0007160,GO:0007229,GO:0008237,GO:0008584,GO:0009986,GO:0016021,GO:0017124,GO:0022617,GO:0030198,GO:0030308,GO:0030336,GO:0030574,GO:0042246,GO:0042995,GO:0045087,GO:0046872,GO:0060317,GO:0070062,GO:0070528,GO:1900121 angiogenesis|acrosomal vesicle|negative regulation of cell-matrix adhesion|immune response to tumor cell|metalloendopeptidase activity|integrin binding|plasma membrane|adherens junction|cell-matrix adhesion|integrin-mediated signaling pathway|metallopeptidase activity|male gonad development|cell surface|integral component of membrane|SH3 domain binding|extracellular matrix disassembly|extracellular matrix organization|negative regulation of cell growth|negative regulation of cell migration|collagen catabolic process|tissue regeneration|cell projection|innate immune response|metal ion binding|cardiac epithelial to mesenchymal transition|extracellular exosome|protein kinase C signaling|negative regulation of receptor binding ADAM17 1657.08854421056 1643.56209393402 1670.6149944871 1.0164599199829 0.0235533294158887 0.856447161340374 1 8.73398 8.52678 9.81721 7.99111 GeneID:6868,Genbank:NM_003183.5,HGNC:HGNC:195,MIM:603639 ADAM metallopeptidase domain 17 hsa04330,hsa05010,hsa05120 Notch signaling pathway|Alzheimer disease|Epithelial cell signaling in Helicobacter pylori infection ADAM19 12076.8530195318 11821.834660166 12331.8713788975 1.04314361800796 0.0609377990120128 0.645469333268455 1 45.7938 47.1047 54.7246 43.892 GeneID:8728,Genbank:NM_033274.4,HGNC:HGNC:197,MIM:603640 ADAM metallopeptidase domain 19 GO:0004222,GO:0005794,GO:0005886,GO:0006509,GO:0007507,GO:0016021,GO:0017124,GO:0030198,GO:0046872 metalloendopeptidase activity|Golgi apparatus|plasma membrane|membrane protein ectodomain proteolysis|heart development|integral component of membrane|SH3 domain binding|extracellular matrix organization|metal ion binding ADAM20 0.995346334121811 0.538097676642304 1.45259499160132 2.69950058261805 1.43269252815597 0.83528100889094 1 0.00322679 0 0 0.00869699 GeneID:8748,Genbank:XM_005268151.3,HGNC:HGNC:199,MIM:603712 ADAM metallopeptidase domain 20 GO:0004222,GO:0005886,GO:0007338,GO:0007339,GO:0008237,GO:0016021,GO:0019031,GO:0046872 metalloendopeptidase activity|plasma membrane|single fertilization|binding of sperm to zona pellucida|metallopeptidase activity|integral component of membrane|viral envelope|metal ion binding ADAM21 4.7012889092162 5.04479284362845 4.35778497480395 0.863818418293988 -0.21120001694151 0.956417090277108 1 0.0506601 0.0794556 0 0.135266 GeneID:8747,Genbank:NM_003813.3,HGNC:HGNC:200,MIM:603713 ADAM metallopeptidase domain 21 GO:0004222,GO:0005886,GO:0007338,GO:0007339,GO:0008237,GO:0016021,GO:0030424,GO:0043025,GO:0046872 metalloendopeptidase activity|plasma membrane|single fertilization|binding of sperm to zona pellucida|metallopeptidase activity|integral component of membrane|axon|neuronal cell body|metal ion binding ADAM22 244.822495653891 261.827313809904 227.817677497878 0.870106614099403 -0.200735909777894 0.535362271397845 1 0.886007 0.786456 0.926022 0.565582 GeneID:53616,Genbank:NM_001324418.1,HGNC:HGNC:201,MIM:603709 ADAM metallopeptidase domain 22 GO:0004222,GO:0005178,GO:0005886,GO:0007155,GO:0007162,GO:0007417,GO:0008344,GO:0016021,GO:0022011,GO:0030424 metalloendopeptidase activity|integrin binding|plasma membrane|cell adhesion|negative regulation of cell adhesion|central nervous system development|adult locomotory behavior|integral component of membrane|myelination in peripheral nervous system|axon ADAM23 118.947632129994 97.8201412910231 140.075122968964 1.43196606670429 0.517997305467052 0.0596571773863915 0.879410748501007 0.605942 0.538867 0.948819 0.664671 GeneID:8745,Genbank:XM_011512086.2,HGNC:HGNC:202,MIM:603710 ADAM metallopeptidase domain 23 ADAM28 10.7862770720094 10.9158410120089 10.65671313201 0.976261299544965 -0.0346607533452742 1 1 0.0255426 0.0245839 0.00492507 0.0228864 GeneID:10863,Genbank:NM_014265.5,HGNC:HGNC:206,MIM:606188 ADAM metallopeptidase domain 28 GO:0004222,GO:0005576,GO:0005739,GO:0005886,GO:0007283,GO:0008237,GO:0016021,GO:0046872 metalloendopeptidase activity|extracellular region|mitochondrion|plasma membrane|spermatogenesis|metallopeptidase activity|integral component of membrane|metal ion binding ADAM32 9.45158243164584 9.69556683466942 9.20759802862226 0.94967093576187 -0.0745003936378733 0.99409093947664 1 0.11992 0.0431677 0.0722693 0.133862 GeneID:203102,Genbank:NM_145004.6,HGNC:HGNC:15479 ADAM metallopeptidase domain 32 GO:0004222,GO:0016021 metalloendopeptidase activity|integral component of membrane ADAM8 14.8478581885563 13.7023819445903 15.9933344325223 1.16719374027057 0.223044051129905 0.783321825075146 1 0.181132 0.0586002 0.114716 0.0954985 GeneID:101,Genbank:NM_001164490.1,HGNC:HGNC:215,MIM:602267 ADAM metallopeptidase domain 8 GO:0000902,GO:0001525,GO:0002102,GO:0002523,GO:0002675,GO:0004222,GO:0004252,GO:0005509,GO:0005737,GO:0005886,GO:0005887,GO:0006954,GO:0008237,GO:0008270,GO:0009986,GO:0010954,GO:0022407,GO:0022617,GO:0032010,GO:0032127,GO:0033089,GO:0035579,GO:0042581,GO:0043312,GO:0043406,GO:0043524,GO:0043621,GO:0045089,GO:0045780,GO:0045785,GO:0048247,GO:0050714,GO:0050839,GO:0051044,GO:0051092,GO:0051897,GO:0070245,GO:0070820,GO:0070821,GO:0071133,GO:0071456,GO:0098609,GO:0101003,GO:2000309,GO:2000391,GO:2000415,GO:2000418 cell morphogenesis|angiogenesis|podosome|leukocyte migration involved in inflammatory response|positive regulation of acute inflammatory response|metalloendopeptidase activity|serine-type endopeptidase activity|calcium ion binding|cytoplasm|plasma membrane|integral component of plasma membrane|inflammatory response|metallopeptidase activity|zinc ion binding|cell surface|positive regulation of protein processing|regulation of cell-cell adhesion|extracellular matrix disassembly|phagolysosome|dense core granule membrane|positive regulation of T cell differentiation in thymus|specific granule membrane|specific granule|neutrophil degranulation|positive regulation of MAP kinase activity|negative regulation of neuron apoptotic process|protein self-association|positive regulation of innate immune response|positive regulation of bone resorption|positive regulation of cell adhesion|lymphocyte chemotaxis|positive regulation of protein secretion|cell adhesion molecule binding|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling|positive regulation of thymocyte apoptotic process|tertiary granule|tertiary granule membrane|alpha9-beta1 integrin-ADAM8 complex|cellular response to hypoxia|cell-cell adhesion|ficolin-1-rich granule membrane|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of neutrophil extravasation|positive regulation of fibronectin-dependent thymocyte migration|positive regulation of eosinophil migration ADAM9 5792.44647365879 6242.14264434239 5342.75030297519 0.855916086412672 -0.224458732432111 0.362568715364135 1 56.4487 48.0096 52.455 37.3369 GeneID:8754,Genbank:NM_003816.2,HGNC:HGNC:216,MIM:602713 ADAM metallopeptidase domain 9 ADAMTS1 263.81564873462 270.726051285146 256.905246184093 0.948949112819234 -0.0755973697608132 0.806850094008315 1 2.09685 2.36977 2.73645 1.61796 GeneID:9510,Genbank:NM_006988.4,HGNC:HGNC:217,MIM:605174 ADAM metallopeptidase with thrombospondin type 1 motif 1 ADAMTS10 113.586246576142 124.908338567625 102.26415458466 0.818713592361926 -0.288569247593284 0.305289262554068 1 0.862651 0.870019 0.863287 0.736364 GeneID:81794,Genbank:NM_030957.3,HGNC:HGNC:13201,MIM:608990 ADAM metallopeptidase with thrombospondin type 1 motif 10 GO:0001527,GO:0004222,GO:0005578,GO:0031012,GO:0046872 microfibril|metalloendopeptidase activity|proteinaceous extracellular matrix|extracellular matrix|metal ion binding ADAMTS12 543.838208418113 542.89289081084 544.783526025387 1.0034825197503 0.00501548576958824 0.981143530607371 1 1.77362 1.78477 2.05852 1.49414 GeneID:81792,Genbank:NM_001324512.1,HGNC:HGNC:14605,MIM:606184 ADAM metallopeptidase with thrombospondin type 1 motif 12 GO:0004222,GO:0005578,GO:0007160,GO:0016477,GO:0030167,GO:0031012,GO:0032331,GO:0046872,GO:0050727,GO:0051603,GO:0071347,GO:0071356,GO:0071773,GO:1901509,GO:1902203,GO:1902548,GO:2001113 metalloendopeptidase activity|proteinaceous extracellular matrix|cell-matrix adhesion|cell migration|proteoglycan catabolic process|extracellular matrix|negative regulation of chondrocyte differentiation|metal ion binding|regulation of inflammatory response|proteolysis involved in cellular protein catabolic process|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to BMP stimulus|regulation of endothelial tube morphogenesis|negative regulation of hepatocyte growth factor receptor signaling pathway|negative regulation of cellular response to vascular endothelial growth factor stimulus|negative regulation of cellular response to hepatocyte growth factor stimulus ADAMTS13 7.8506671221978 8.9173377846024 6.7839964597932 0.760764773485104 -0.394477649812628 0.786008524165569 1 0.00878356 0.067871 0.0324616 0.0529969 GeneID:11093,Genbank:XM_017014233.1,HGNC:HGNC:1366,MIM:604134 ADAM metallopeptidase with thrombospondin type 1 motif 13 ADAMTS14 9.53743455017883 12.2900026685111 6.7848664318466 0.552063869703666 -0.857092909089863 0.377950324600692 1 0.0698988 0.0484856 0.0324107 0.0363763 GeneID:140766,Genbank:NM_139155.3,HGNC:HGNC:14899,MIM:607506 ADAM metallopeptidase with thrombospondin type 1 motif 14 GO:0004222,GO:0005576,GO:0005578,GO:0030199,GO:0030574,GO:0046872 metalloendopeptidase activity|extracellular region|proteinaceous extracellular matrix|collagen fibril organization|collagen catabolic process|metal ion binding ADAMTS15 682.957768620086 559.055438420325 806.860098819848 1.44325596956846 0.529327192606398 0.00119705975351895 0.11383325497048 3.98125 3.71717 5.30894 5.90153 GeneID:170689,Genbank:NM_139055.3,HGNC:HGNC:16305,MIM:607509 ADAM metallopeptidase with thrombospondin type 1 motif 15 GO:0004222,GO:0005578,GO:0005615,GO:0008201,GO:0008270,GO:0009986,GO:0050840 metalloendopeptidase activity|proteinaceous extracellular matrix|extracellular space|heparin binding|zinc ion binding|cell surface|extracellular matrix binding ADAMTS16 54.9050099279676 51.1585139014507 58.6515059544845 1.14646617897205 0.197193795695848 0.613682829215454 1 0.443851 0.300086 0.498625 0.34432 GeneID:170690,Genbank:NM_139056.3,HGNC:HGNC:17108,MIM:607510 ADAM metallopeptidase with thrombospondin type 1 motif 16 GO:0001658,GO:0003073,GO:0004222,GO:0005578,GO:0046872,GO:0048232,GO:1902017 branching involved in ureteric bud morphogenesis|regulation of systemic arterial blood pressure|metalloendopeptidase activity|proteinaceous extracellular matrix|metal ion binding|male gamete generation|regulation of cilium assembly ADAMTS17 5.94428086047689 6.07296192222811 5.81559979872566 0.957621647097693 -0.062472330025007 1 1 0.00587844 0.00891637 0.00739354 0.00863633 GeneID:170691,Genbank:NM_139057.3,HGNC:HGNC:17109,MIM:607511 ADAM metallopeptidase with thrombospondin type 1 motif 17 GO:0003676,GO:0004222,GO:0005578,GO:0046872 nucleic acid binding|metalloendopeptidase activity|proteinaceous extracellular matrix|metal ion binding ADAMTS18 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0070154 0 GeneID:170692,Genbank:NM_199355.3,HGNC:HGNC:17110,MIM:607512 ADAM metallopeptidase with thrombospondin type 1 motif 18 GO:0001654,GO:0004222,GO:0005578,GO:0046872,GO:0090331 eye development|metalloendopeptidase activity|proteinaceous extracellular matrix|metal ion binding|negative regulation of platelet aggregation ADAMTS19 3.50599661308886 3.6226049124413 3.38938831373641 0.935621851032127 -0.0960025393026586 1 1 0.0148387 0.0141484 0 0.00884928 GeneID:171019,Genbank:NM_133638.4,HGNC:HGNC:17111,MIM:607513 ADAM metallopeptidase with thrombospondin type 1 motif 19 GO:0004222,GO:0005578,GO:0046872 metalloendopeptidase activity|proteinaceous extracellular matrix|metal ion binding ADAMTS3 79.456806260766 79.418959080707 79.4946534408251 1.00095310189147 0.00137438051393811 1 1 0.388583 0.419688 0.540149 0.32896 GeneID:9508,Genbank:NM_014243.2,HGNC:HGNC:219,MIM:605011 ADAM metallopeptidase with thrombospondin type 1 motif 3 GO:0004175,GO:0004222,GO:0005576,GO:0005578,GO:0005615,GO:0008201,GO:0008270,GO:0010573,GO:0016485,GO:0030199,GO:0030574,GO:0032964,GO:0070062,GO:0097435,GO:1900748 endopeptidase activity|metalloendopeptidase activity|extracellular region|proteinaceous extracellular matrix|extracellular space|heparin binding|zinc ion binding|vascular endothelial growth factor production|protein processing|collagen fibril organization|collagen catabolic process|collagen biosynthetic process|extracellular exosome|supramolecular fiber organization|positive regulation of vascular endothelial growth factor signaling pathway ADAMTS4 700.959955160045 752.044467239591 649.875443080498 0.864144969333916 -0.210654735050837 0.188513394451983 1 7.36427 7.59759 6.63572 6.59932 GeneID:9507,Genbank:NM_001320336.1,HGNC:HGNC:220,MIM:603876 ADAM metallopeptidase with thrombospondin type 1 motif 4 GO:0001501,GO:0002020,GO:0004222,GO:0005576,GO:0005578,GO:0005615,GO:0006508,GO:0008233,GO:0008237,GO:0016607,GO:0022617,GO:0031012,GO:0046872 skeletal system development|protease binding|metalloendopeptidase activity|extracellular region|proteinaceous extracellular matrix|extracellular space|proteolysis|peptidase activity|metallopeptidase activity|nuclear speck|extracellular matrix disassembly|extracellular matrix|metal ion binding ADAMTS5 8.22770888483253 7.24520982488261 9.21020794478245 1.27121341788492 0.346206257783553 0.775714614981866 1 0.028852 0.0273131 0.050752 0.0300425 GeneID:11096,Genbank:NM_007038.4,HGNC:HGNC:221,MIM:605007 ADAM metallopeptidase with thrombospondin type 1 motif 5 GO:0004222,GO:0005178,GO:0005576,GO:0005578,GO:0005615,GO:0005788,GO:0006508,GO:0008201,GO:0008237,GO:0008270,GO:0022617,GO:0036066,GO:0042742,GO:0044691,GO:0050840 metalloendopeptidase activity|integrin binding|extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|proteolysis|heparin binding|metallopeptidase activity|zinc ion binding|extracellular matrix disassembly|protein O-linked fucosylation|defense response to bacterium|tooth eruption|extracellular matrix binding ADAMTS6 34.6108233828683 49.352115772784 19.8695309929526 0.402607480587691 -1.31255411660103 0.00741879809947517 0.341036183119742 0.115875 0.120342 0.0500874 0.0493072 GeneID:11174,Genbank:XM_011543117.2,HGNC:HGNC:222,MIM:605008 ADAM metallopeptidase with thrombospondin type 1 motif 6 GO:0004222,GO:0005578,GO:0008237,GO:0046872 metalloendopeptidase activity|proteinaceous extracellular matrix|metallopeptidase activity|metal ion binding ADAMTS7 103.995105120542 102.836525170183 105.153685070901 1.02253246010485 0.0321466419826584 0.961524726512576 1 0.542133 0.744735 0.553561 0.735351 GeneID:11173,Genbank:XM_005254137.4,HGNC:HGNC:223,MIM:605009 ADAM metallopeptidase with thrombospondin type 1 motif 7 GO:0004222,GO:0005578,GO:0005615,GO:0005788,GO:0008237,GO:0009986,GO:0032331,GO:0036066,GO:0046872,GO:0051603,GO:0071347,GO:0071356,GO:0071773 metalloendopeptidase activity|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|metallopeptidase activity|cell surface|negative regulation of chondrocyte differentiation|protein O-linked fucosylation|metal ion binding|proteolysis involved in cellular protein catabolic process|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to BMP stimulus ADAMTS9 218.606789588018 171.617992231882 265.595586944153 1.54759756532574 0.630030364253522 0.00459597215043731 0.267669418041469 0.696274 0.71788 1.21694 0.978542 GeneID:56999,Genbank:NM_001318781.1,HGNC:HGNC:13202,MIM:605421 ADAM metallopeptidase with thrombospondin type 1 motif 9 GO:0003179,GO:0003229,GO:0004222,GO:0005578,GO:0005615,GO:0005783,GO:0006508,GO:0006516,GO:0007275,GO:0008237,GO:0008270,GO:0009986,GO:0010596,GO:0015031,GO:0016192,GO:0030198,GO:0035909,GO:0043231,GO:0045636,GO:0090673,GO:1903671 heart valve morphogenesis|ventricular cardiac muscle tissue development|metalloendopeptidase activity|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum|proteolysis|glycoprotein catabolic process|multicellular organism development|metallopeptidase activity|zinc ion binding|cell surface|negative regulation of endothelial cell migration|protein transport|vesicle-mediated transport|extracellular matrix organization|aorta morphogenesis|intracellular membrane-bounded organelle|positive regulation of melanocyte differentiation|endothelial cell-matrix adhesion|negative regulation of sprouting angiogenesis ADAMTSL1 288.135989192493 254.937905218032 321.334073166954 1.26044054881575 0.33392807222151 0.0965059973009506 1 0.416968 0.421067 0.58072 0.482391 GeneID:92949,Genbank:XM_011518064.3,HGNC:HGNC:14632,MIM:609198 ADAMTS like 1 GO:0005578,GO:0005788,GO:0008233,GO:0036066 proteinaceous extracellular matrix|endoplasmic reticulum lumen|peptidase activity|protein O-linked fucosylation ADAMTSL3 1.24081702112719 1.02816907859967 1.45346496365472 1.41364391704357 0.499418765260228 1 1 0.00367227 0.00347567 0.00352579 0.00655026 GeneID:57188,Genbank:NM_001301110.1,HGNC:HGNC:14633,MIM:609199 ADAMTS like 3 GO:0005578,GO:0008233,GO:0043231 proteinaceous extracellular matrix|peptidase activity|intracellular membrane-bounded organelle ADAMTSL4 10.0005562790819 12.7320477957835 7.26906476238037 0.570926600258892 -0.808622813833693 0.388330099439436 1 0.0670493 0.0941346 0.0386287 0.0217682 GeneID:54507,Genbank:NM_001288608.1,HGNC:HGNC:19706,MIM:610113 ADAMTS like 4 GO:0002020,GO:0002064,GO:0005614,GO:0005615,GO:0005788,GO:0006915,GO:0008233,GO:0030198,GO:0036066,GO:0043065 protease binding|epithelial cell development|interstitial matrix|extracellular space|endoplasmic reticulum lumen|apoptotic process|peptidase activity|extracellular matrix organization|protein O-linked fucosylation|positive regulation of apoptotic process ADAMTSL5 113.579504157869 96.8017808675314 130.357227448206 1.3466407981336 0.42936507881817 0.131570265330491 1 1.0164 0.980846 1.60233 1.80278 GeneID:339366,Genbank:NM_213604.2,HGNC:HGNC:27912 ADAMTS like 5 GO:0001527,GO:0005576,GO:0005578,GO:0008201 microfibril|extracellular region|proteinaceous extracellular matrix|heparin binding ADAP1 7.15640826444302 6.56303332418548 7.74978320470056 1.18082338179539 0.239793193979005 0.916252818686249 1 0.078412 0.132877 0.0541044 0.185985 GeneID:11033,Genbank:NM_001284308.1,HGNC:HGNC:16486,MIM:608114 ArfGAP with dual PH domains 1 GO:0005096,GO:0005547,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007166,GO:0043087,GO:0043533,GO:0046872 GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|cytoplasm|cytosol|plasma membrane|cell surface receptor signaling pathway|regulation of GTPase activity|inositol 1,3,4,5 tetrakisphosphate binding|metal ion binding ADAP2 9.39344159174542 8.12930007942745 10.6575831040634 1.31100869692757 0.390677256095642 0.734626568899875 1 0.0618743 0.0908558 0.0467641 0.141663 GeneID:55803,Genbank:NM_001346712.1,HGNC:HGNC:16487,MIM:608635 ArfGAP with dual PH domains 2 GO:0005096,GO:0005546,GO:0005547,GO:0005737,GO:0005740,GO:0005886,GO:0007507,GO:0030674,GO:0043325,GO:0043533,GO:0046872 GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|mitochondrial envelope|plasma membrane|heart development|protein binding, bridging|phosphatidylinositol-3,4-bisphosphate binding|inositol 1,3,4,5 tetrakisphosphate binding|metal ion binding ADAR 8392.51115470233 7011.22328514349 9773.79902426116 1.39402193123295 0.479253258359945 0.346386477921517 1 21.7709 21.557 40.7316 20.5336 GeneID:103,Genbank:NM_001025107.2,HGNC:HGNC:225,MIM:146920 adenosine deaminase, RNA specific GO:0001649,GO:0001701,GO:0002244,GO:0002566,GO:0003677,GO:0003723,GO:0003726,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006382,GO:0006397,GO:0006606,GO:0006611,GO:0009615,GO:0016020,GO:0016553,GO:0030218,GO:0031054,GO:0035280,GO:0035455,GO:0043066,GO:0044387,GO:0044530,GO:0045070,GO:0045071,GO:0045087,GO:0046872,GO:0051607,GO:0060216,GO:0060337,GO:0060339,GO:0061484,GO:0098586,GO:1900369 osteoblast differentiation|in utero embryonic development|hematopoietic progenitor cell differentiation|somatic diversification of immune receptors via somatic mutation|DNA binding|RNA binding|double-stranded RNA adenosine deaminase activity|nucleus|nucleoplasm|nucleolus|cytoplasm|adenosine to inosine editing|mRNA processing|protein import into nucleus|protein export from nucleus|response to virus|membrane|base conversion or substitution editing|erythrocyte differentiation|pre-miRNA processing|miRNA loading onto RISC involved in gene silencing by miRNA|response to interferon-alpha|negative regulation of apoptotic process|negative regulation of protein kinase activity by regulation of protein phosphorylation|supraspliceosomal complex|positive regulation of viral genome replication|negative regulation of viral genome replication|innate immune response|metal ion binding|defense response to virus|definitive hemopoiesis|type I interferon signaling pathway|negative regulation of type I interferon-mediated signaling pathway|hematopoietic stem cell homeostasis|cellular response to virus|negative regulation of RNA interference hsa04623,hsa05162,hsa05164 Cytosolic DNA-sensing pathway|Measles|Influenza A ADARB1 912.306002428601 843.214314311312 981.397690545889 1.16387693364461 0.218938518205762 0.154772059848249 1 2.07465 2.04426 2.63169 2.37015 GeneID:104,Genbank:NM_015833.3,HGNC:HGNC:226,MIM:601218 adenosine deaminase, RNA specific B1 GO:0003723,GO:0003725,GO:0003726,GO:0003729,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006382,GO:0006396,GO:0006397,GO:0007274,GO:0008285,GO:0016553,GO:0021610,GO:0021618,GO:0021965,GO:0030336,GO:0035264,GO:0044387,GO:0045070,GO:0045087,GO:0046872,GO:0050884,GO:0051607,GO:0051726,GO:0060384,GO:0060415,GO:0061744,GO:0097049 RNA binding|double-stranded RNA binding|double-stranded RNA adenosine deaminase activity|mRNA binding|nucleus|nucleoplasm|nucleolus|cytosol|adenosine to inosine editing|RNA processing|mRNA processing|neuromuscular synaptic transmission|negative regulation of cell proliferation|base conversion or substitution editing|facial nerve morphogenesis|hypoglossal nerve morphogenesis|spinal cord ventral commissure morphogenesis|negative regulation of cell migration|multicellular organism growth|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of viral genome replication|innate immune response|metal ion binding|neuromuscular process controlling posture|defense response to virus|regulation of cell cycle|innervation|muscle tissue morphogenesis|motor behavior|motor neuron apoptotic process ADAT1 1019.43046790621 1018.69605982992 1020.16487598251 1.00144185906917 0.00207866471783283 1 1 6.20475 6.99645 6.96807 6.36135 GeneID:23536,Genbank:NM_001324448.1,HGNC:HGNC:228,MIM:604230 adenosine deaminase, tRNA specific 1 GO:0003723,GO:0008033,GO:0008251,GO:0046872 RNA binding|tRNA processing|tRNA-specific adenosine deaminase activity|metal ion binding ADAT2 114.961571208611 124.264379686505 105.658762730717 0.850273932057389 -0.234000386868553 0.413739522622853 1 0.45564 0.427631 0.495636 0.348387 GeneID:134637,Genbank:NM_182503.2,HGNC:HGNC:21172,MIM:615388 adenosine deaminase, tRNA specific 2 GO:0002100,GO:0005654,GO:0006400,GO:0008270,GO:0052717,GO:0052718 tRNA wobble adenosine to inosine editing|nucleoplasm|tRNA modification|zinc ion binding|tRNA-specific adenosine-34 deaminase activity|tRNA-specific adenosine-34 deaminase complex ADAT3 138.697542015356 149.950006342135 127.445077688576 0.849917121028922 -0.234605930001986 0.480926052678474 1 6.14543 7.6115 5.6524 6.71154 GeneID:113179,Genbank:NM_138422.3,HGNC:HGNC:25151,MIM:615302 adenosine deaminase, tRNA specific 3 GO:0003824,GO:0005654,GO:0006400,GO:0009451,GO:0046872 catalytic activity|nucleoplasm|tRNA modification|RNA modification|metal ion binding ADCK1 180.35869331019 175.586589722226 185.130796898154 1.0543561281703 0.076362246069423 0.766840575946664 1 1.59405 1.46025 1.8218 1.64747 GeneID:57143,Genbank:XM_005267885.3,HGNC:HGNC:19038 aarF domain containing kinase 1 GO:0004674,GO:0005524,GO:0005576,GO:0005739 protein serine/threonine kinase activity|ATP binding|extracellular region|mitochondrion ADCK2 975.854471113336 938.364601530194 1013.34434069648 1.07990469700585 0.110903998292594 0.486001269300414 1 18.1512 19.4474 20.7336 20.6139 GeneID:90956,Genbank:XM_006716170.4,HGNC:HGNC:19039 aarF domain containing kinase 2 GO:0004674,GO:0005524,GO:0016021 protein serine/threonine kinase activity|ATP binding|integral component of membrane ADCK5 96.0346811089438 90.7866538750962 101.282708342791 1.11561230665177 0.157835754365509 0.633317610628194 1 1.00715 1.24636 1.4789 1.23758 GeneID:203054,Genbank:XM_017013174.1,HGNC:HGNC:21738 aarF domain containing kinase 5 GO:0004674,GO:0016021 protein serine/threonine kinase activity|integral component of membrane ADCY1 41.984858668229 50.5243636754385 33.4453536610196 0.661964866611046 -0.595173445998487 0.184019470278098 1 0.170826 0.131452 0.131231 0.0673947 GeneID:107,Genbank:NM_001281768.1,HGNC:HGNC:232,MIM:103072 adenylate cyclase 1 GO:0003091,GO:0004016,GO:0004383,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0006171,GO:0006182,GO:0007165,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0007409,GO:0007420,GO:0007616,GO:0007623,GO:0008074,GO:0008294,GO:0010226,GO:0019933,GO:0034199,GO:0042752,GO:0045121,GO:0046872,GO:0070062,GO:0071277,GO:0071377,GO:1904322 renal water homeostasis|adenylate cyclase activity|guanylate cyclase activity|calmodulin binding|ATP binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|cAMP biosynthetic process|cGMP biosynthetic process|signal transduction|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|axonogenesis|brain development|long-term memory|circadian rhythm|guanylate cyclase complex, soluble|calcium- and calmodulin-responsive adenylate cyclase activity|response to lithium ion|cAMP-mediated signaling|activation of protein kinase A activity|regulation of circadian rhythm|membrane raft|metal ion binding|extracellular exosome|cellular response to calcium ion|cellular response to glucagon stimulus|cellular response to forskolin hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04720,hsa04723,hsa04724,hsa04725,hsa04727,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05142,hsa05146,hsa05163,hsa05166,hsa05200,hsa05414 Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Chagas disease (American trypanosomiasis)|Amoebiasis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy (DCM) ADCY10 2.99658855360761 3.084507235799 2.90866987141623 0.942993369462067 -0.0846804680780024 1 1 0 0.00827617 0 0.00389135 GeneID:55811,Genbank:XM_011509762.3,HGNC:HGNC:21285,MIM:605205 adenylate cyclase 10 GO:0000287,GO:0003351,GO:0004016,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0006171,GO:0007283,GO:0030145,GO:0030424,GO:0030425,GO:0030426,GO:0035556,GO:0043025,GO:0043065,GO:0045177,GO:0045178,GO:0048471,GO:0051117,GO:0071241,GO:0071890 magnesium ion binding|epithelial cilium movement|adenylate cyclase activity|ATP binding|nucleus|cytoplasm|mitochondrion|cytosol|cytoskeleton|plasma membrane|cilium|cAMP biosynthetic process|spermatogenesis|manganese ion binding|axon|dendrite|growth cone|intracellular signal transduction|neuronal cell body|positive regulation of apoptotic process|apical part of cell|basal part of cell|perinuclear region of cytoplasm|ATPase binding|cellular response to inorganic substance|bicarbonate binding hsa00230,hsa04024,hsa04371,hsa04713,hsa04714 Purine metabolism|cAMP signaling pathway|Apelin signaling pathway|Circadian entrainment|Thermogenesis ADCY3 1153.7399085852 1122.05106536652 1185.42875180387 1.05648378081317 0.0792706191232886 0.606196588372894 1 6.09947 6.02592 7.17583 6.63215 GeneID:109,Genbank:NM_004036.4,HGNC:HGNC:234,MIM:600291 adenylate cyclase 3 GO:0003091,GO:0004016,GO:0004383,GO:0005516,GO:0005524,GO:0005737,GO:0005794,GO:0005886,GO:0005887,GO:0005929,GO:0006171,GO:0006182,GO:0007165,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0007338,GO:0007340,GO:0007608,GO:0008074,GO:0008355,GO:0016020,GO:0016021,GO:0030317,GO:0034199,GO:0046872,GO:0071377,GO:1904322 renal water homeostasis|adenylate cyclase activity|guanylate cyclase activity|calmodulin binding|ATP binding|cytoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|cilium|cAMP biosynthetic process|cGMP biosynthetic process|signal transduction|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|single fertilization|acrosome reaction|sensory perception of smell|guanylate cyclase complex, soluble|olfactory learning|membrane|integral component of membrane|flagellated sperm motility|activation of protein kinase A activity|metal ion binding|cellular response to glucagon stimulus|cellular response to forskolin hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04740,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05110,hsa05163,hsa05166,hsa05200,hsa05414 Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Vibrio cholerae infection|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy (DCM) ADCY5 6.69709304330511 6.61105959887042 6.78312648773981 1.02602712716412 0.0370688749096696 1 1 0.0108065 0.0237565 0.0151419 0.0376531 GeneID:111,Genbank:XM_005247077.4,HGNC:HGNC:236,MIM:600293 adenylate cyclase 5 GO:0001973,GO:0003091,GO:0004016,GO:0004383,GO:0005524,GO:0005886,GO:0005929,GO:0006171,GO:0006182,GO:0007186,GO:0007189,GO:0007190,GO:0007191,GO:0007193,GO:0007195,GO:0007204,GO:0007626,GO:0008074,GO:0008179,GO:0016021,GO:0034199,GO:0045111,GO:0046872,GO:0046982,GO:0050885,GO:0061178,GO:0071377,GO:0097110,GO:1904322 adenosine receptor signaling pathway|renal water homeostasis|adenylate cyclase activity|guanylate cyclase activity|ATP binding|plasma membrane|cilium|cAMP biosynthetic process|cGMP biosynthetic process|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-activating dopamine receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting dopamine receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|locomotory behavior|guanylate cyclase complex, soluble|adenylate cyclase binding|integral component of membrane|activation of protein kinase A activity|intermediate filament cytoskeleton|metal ion binding|protein heterodimerization activity|neuromuscular process controlling balance|regulation of insulin secretion involved in cellular response to glucose stimulus|cellular response to glucagon stimulus|scaffold protein binding|cellular response to forskolin hsa00230,hsa01522,hsa04015,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04970,hsa04971,hsa04972,hsa04976,hsa05012,hsa05030,hsa05031,hsa05032,hsa05034,hsa05163,hsa05166,hsa05200,hsa05414 Purine metabolism|Endocrine resistance|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Parkinson disease|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy (DCM) ADCY6 1006.83979930173 878.663151386513 1135.01644721694 1.29175378007592 0.369331105546244 0.016250656665072 0.529251203244782 4.70681 4.94746 6.60293 6.1376 GeneID:112,Genbank:NM_015270.4,HGNC:HGNC:237,MIM:600294 adenylate cyclase 6 GO:0003091,GO:0004016,GO:0004383,GO:0005080,GO:0005524,GO:0005886,GO:0005929,GO:0006171,GO:0006182,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0007212,GO:0008074,GO:0010977,GO:0016020,GO:0016021,GO:0019901,GO:0031226,GO:0034199,GO:0035811,GO:0046872,GO:0071377,GO:0071380,GO:0071870,GO:0097746,GO:1904117,GO:1904322 renal water homeostasis|adenylate cyclase activity|guanylate cyclase activity|protein kinase C binding|ATP binding|plasma membrane|cilium|cAMP biosynthetic process|cGMP biosynthetic process|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|dopamine receptor signaling pathway|guanylate cyclase complex, soluble|negative regulation of neuron projection development|membrane|integral component of membrane|protein kinase binding|intrinsic component of plasma membrane|activation of protein kinase A activity|negative regulation of urine volume|metal ion binding|cellular response to glucagon stimulus|cellular response to prostaglandin E stimulus|cellular response to catecholamine stimulus|regulation of blood vessel diameter|cellular response to vasopressin|cellular response to forskolin hsa00230,hsa01522,hsa04015,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04742,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04961,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05163,hsa05166,hsa05200,hsa05414 Purine metabolism|Endocrine resistance|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy (DCM) ADCY7 528.024577909407 589.824075539161 466.225080279654 0.790447693837312 -0.339258096362192 0.0469834308339857 0.795440410398642 3.31782 3.50936 2.8881 2.4121 GeneID:113,Genbank:XM_011522837.3,HGNC:HGNC:238,MIM:600385 adenylate cyclase 7 GO:0003091,GO:0004016,GO:0004383,GO:0005524,GO:0005886,GO:0006171,GO:0006182,GO:0007165,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0008074,GO:0016021,GO:0034199,GO:0046872,GO:0060135,GO:0071361,GO:0071377 renal water homeostasis|adenylate cyclase activity|guanylate cyclase activity|ATP binding|plasma membrane|cAMP biosynthetic process|cGMP biosynthetic process|signal transduction|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|guanylate cyclase complex, soluble|integral component of membrane|activation of protein kinase A activity|metal ion binding|maternal process involved in female pregnancy|cellular response to ethanol|cellular response to glucagon stimulus hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05163,hsa05166,hsa05200,hsa05414 Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy (DCM) ADCY8 12.1396647254526 9.253521707397 15.0258077435081 1.62379342899222 0.699368111633948 0.413483510117588 1 0.0627714 0.0646369 0.126717 0.0786494 GeneID:114,Genbank:XM_006716501.3,HGNC:HGNC:239,MIM:103070 adenylate cyclase 8 GO:0003091,GO:0004016,GO:0004383,GO:0005524,GO:0005886,GO:0006182,GO:0007165,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0007611,GO:0007616,GO:0008074,GO:0008294,GO:0016020,GO:0016021,GO:0034199,GO:0046872,GO:0071377 renal water homeostasis|adenylate cyclase activity|guanylate cyclase activity|ATP binding|plasma membrane|cGMP biosynthetic process|signal transduction|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|learning or memory|long-term memory|guanylate cyclase complex, soluble|calcium- and calmodulin-responsive adenylate cyclase activity|membrane|integral component of membrane|activation of protein kinase A activity|metal ion binding|cellular response to glucagon stimulus hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04720,hsa04723,hsa04724,hsa04725,hsa04727,hsa04742,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05163,hsa05166,hsa05200,hsa05414 Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy (DCM) ADCY9 671.581017109716 627.924166377141 715.23786784229 1.13905134750413 0.18783278402569 0.369711787847905 1 3.27912 3.46871 3.53175 4.14624 GeneID:115,Genbank:XM_011522353.2,HGNC:HGNC:240,MIM:603302 adenylate cyclase 9 GO:0003091,GO:0004016,GO:0004383,GO:0005524,GO:0005886,GO:0005887,GO:0006171,GO:0006182,GO:0007165,GO:0007186,GO:0007189,GO:0007190,GO:0007193,GO:0008074,GO:0016021,GO:0030424,GO:0030425,GO:0034199,GO:0046872,GO:0071377,GO:0071880 renal water homeostasis|adenylate cyclase activity|guanylate cyclase activity|ATP binding|plasma membrane|integral component of plasma membrane|cAMP biosynthetic process|cGMP biosynthetic process|signal transduction|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|guanylate cyclase complex, soluble|integral component of membrane|axon|dendrite|activation of protein kinase A activity|metal ion binding|cellular response to glucagon stimulus|adenylate cyclase-activating adrenergic receptor signaling pathway hsa00230,hsa01522,hsa04015,hsa04020,hsa04022,hsa04024,hsa04062,hsa04072,hsa04114,hsa04211,hsa04213,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04714,hsa04723,hsa04724,hsa04725,hsa04727,hsa04750,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04921,hsa04923,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04961,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05032,hsa05110,hsa05163,hsa05166,hsa05200,hsa05414 Purine metabolism|Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|GABAergic synapse|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Morphine addiction|Vibrio cholerae infection|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Dilated cardiomyopathy (DCM) ADCYAP1R1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00620382 0 0 GeneID:117,Genbank:XM_017011738.2,HGNC:HGNC:242,MIM:102981 ADCYAP receptor type I GO:0004872,GO:0004999,GO:0005768,GO:0005791,GO:0005886,GO:0005887,GO:0005901,GO:0005923,GO:0007166,GO:0007186,GO:0007202,GO:0007283,GO:0008179,GO:0009986,GO:0010524,GO:0019933,GO:0030154,GO:0030306,GO:0032355,GO:0033555,GO:0042923,GO:0043005,GO:0043231,GO:0043235,GO:0043950,GO:0045471,GO:0046545,GO:0051057,GO:0060548,GO:0060732 receptor activity|vasoactive intestinal polypeptide receptor activity|endosome|rough endoplasmic reticulum|plasma membrane|integral component of plasma membrane|caveola|bicellular tight junction|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|activation of phospholipase C activity|spermatogenesis|adenylate cyclase binding|cell surface|positive regulation of calcium ion transport into cytosol|cAMP-mediated signaling|cell differentiation|ADP-ribosylation factor binding|response to estradiol|multicellular organismal response to stress|neuropeptide binding|neuron projection|intracellular membrane-bounded organelle|receptor complex|positive regulation of cAMP-mediated signaling|response to ethanol|development of primary female sexual characteristics|positive regulation of small GTPase mediated signal transduction|negative regulation of cell death|positive regulation of inositol phosphate biosynthetic process hsa04024,hsa04080,hsa04713,hsa04911,hsa04924 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Insulin secretion|Renin secretion ADD1 5394.6540164705 5291.82865342334 5497.47937951765 1.03886193971176 0.0550039390086233 0.682736848664985 1 29.453 30.0314 30.726 32.0056 GeneID:118,Genbank:NM_001354757.1,HGNC:HGNC:243,MIM:102680 adducin 1 GO:0000902,GO:0001701,GO:0003723,GO:0003779,GO:0005198,GO:0005516,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005913,GO:0005925,GO:0006884,GO:0008134,GO:0008290,GO:0016604,GO:0020027,GO:0030036,GO:0030218,GO:0030507,GO:0032092,GO:0035264,GO:0036498,GO:0042803,GO:0045296,GO:0046982,GO:0048873,GO:0051015,GO:0051016,GO:0051017,GO:0055085,GO:0071277,GO:1903142,GO:1903393 cell morphogenesis|in utero embryonic development|RNA binding|actin binding|structural molecule activity|calmodulin binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|cell-cell adherens junction|focal adhesion|cell volume homeostasis|transcription factor binding|F-actin capping protein complex|nuclear body|hemoglobin metabolic process|actin cytoskeleton organization|erythrocyte differentiation|spectrin binding|positive regulation of protein binding|multicellular organism growth|IRE1-mediated unfolded protein response|protein homodimerization activity|cadherin binding|protein heterodimerization activity|homeostasis of number of cells within a tissue|actin filament binding|barbed-end actin filament capping|actin filament bundle assembly|transmembrane transport|cellular response to calcium ion|positive regulation of establishment of endothelial barrier|positive regulation of adherens junction organization ADD2 3293.57274247613 3103.53682758364 3483.60865736862 1.12246409528863 0.166669297636807 0.222363474529815 1 8.65531 9.20472 10.5308 9.60738 GeneID:119,Genbank:XM_011532502.2,HGNC:HGNC:244,MIM:102681 adducin 2 GO:0003779,GO:0005198,GO:0005516,GO:0005829,GO:0006461,GO:0008290,GO:0014069,GO:0019901,GO:0030036,GO:0030097,GO:0030507,GO:0031410,GO:0032092,GO:0042803,GO:0044853,GO:0046982,GO:0050900,GO:0050901,GO:0051015,GO:0051016,GO:0051017,GO:0055085 actin binding|structural molecule activity|calmodulin binding|cytosol|protein complex assembly|F-actin capping protein complex|postsynaptic density|protein kinase binding|actin cytoskeleton organization|hemopoiesis|spectrin binding|cytoplasmic vesicle|positive regulation of protein binding|protein homodimerization activity|plasma membrane raft|protein heterodimerization activity|leukocyte migration|leukocyte tethering or rolling|actin filament binding|barbed-end actin filament capping|actin filament bundle assembly|transmembrane transport ADD3 685.925941202727 732.574864329389 639.277018076065 0.87264394289759 -0.196534970927456 0.241089525830239 1 4.20077 3.77375 3.99088 3.20989 GeneID:120,Genbank:NM_001320591.1,HGNC:HGNC:245,MIM:601568 adducin 3 ADGRA2 203.119157894077 203.683338767212 202.554977020942 0.994460215778576 -0.00801443890831989 0.985532261829682 1 1.47149 1.4137 1.37963 1.61493 GeneID:25960,Genbank:NM_032777.9,HGNC:HGNC:17849,MIM:606823 adhesion G protein-coupled receptor A2 GO:0002040,GO:0004930,GO:0005886,GO:0007166,GO:0007186,GO:0007417,GO:0009986,GO:0010595,GO:0016021,GO:0030175,GO:0043542,GO:0045765,GO:0050920,GO:0090210,GO:1900747 sprouting angiogenesis|G-protein coupled receptor activity|plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|central nervous system development|cell surface|positive regulation of endothelial cell migration|integral component of membrane|filopodium|endothelial cell migration|regulation of angiogenesis|regulation of chemotaxis|regulation of establishment of blood-brain barrier|negative regulation of vascular endothelial growth factor signaling pathway ADGRA3 1471.71709635171 1542.82215854232 1400.6120341611 0.907824681157299 -0.139514383325367 0.334259336345524 1 9.36003 9.7242 9.23871 8.28833 GeneID:166647,Genbank:NM_145290.3,HGNC:HGNC:13839,MIM:612303 adhesion G protein-coupled receptor A3 GO:0004930,GO:0007166,GO:0007186,GO:0009897,GO:0016021 G-protein coupled receptor activity|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|external side of plasma membrane|integral component of membrane ADGRB1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00802325 0 0 GeneID:575,Genbank:XM_017013695.1,HGNC:HGNC:943,MIM:602682 adhesion G protein-coupled receptor B1 GO:0001530,GO:0001786,GO:0001891,GO:0004930,GO:0005615,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0006910,GO:0007155,GO:0007165,GO:0007166,GO:0007186,GO:0007409,GO:0007422,GO:0007517,GO:0008285,GO:0010596,GO:0014069,GO:0016021,GO:0016525,GO:0030165,GO:0030425,GO:0031397,GO:0042177,GO:0043197,GO:0043277,GO:0043652,GO:0045087,GO:0045211,GO:0048167,GO:0048471,GO:0050829,GO:0051965,GO:1901741,GO:1903428 lipopolysaccharide binding|phosphatidylserine binding|phagocytic cup|G-protein coupled receptor activity|extracellular space|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|phagocytosis, recognition|cell adhesion|signal transduction|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|axonogenesis|peripheral nervous system development|muscle organ development|negative regulation of cell proliferation|negative regulation of endothelial cell migration|postsynaptic density|integral component of membrane|negative regulation of angiogenesis|PDZ domain binding|dendrite|negative regulation of protein ubiquitination|negative regulation of protein catabolic process|dendritic spine|apoptotic cell clearance|engulfment of apoptotic cell|innate immune response|postsynaptic membrane|regulation of synaptic plasticity|perinuclear region of cytoplasm|defense response to Gram-negative bacterium|positive regulation of synapse assembly|positive regulation of myoblast fusion|positive regulation of reactive oxygen species biosynthetic process hsa04115 p53 signaling pathway ADGRB2 613.373960157913 641.809861766218 584.938058549608 0.911388393035746 -0.133862097616091 0.400269530846424 1 4.2298 4.754 4.07846 4.13668 GeneID:576,Genbank:XM_011541849.2,HGNC:HGNC:944,MIM:602683 adhesion G protein-coupled receptor B2 GO:0004930,GO:0005813,GO:0005886,GO:0007166,GO:0007186,GO:0007422,GO:0016021,GO:0016525,GO:0033173,GO:0051965 G-protein coupled receptor activity|centrosome|plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|peripheral nervous system development|integral component of membrane|negative regulation of angiogenesis|calcineurin-NFAT signaling cascade|positive regulation of synapse assembly ADGRB3 21.7050047863605 18.2090771115764 25.2009324611445 1.38397637105524 0.468819311722878 0.437282090575065 1 0.0638719 0.0308368 0.0504404 0.0521271 GeneID:577,Genbank:XM_011536011.3,HGNC:HGNC:945,MIM:602684 adhesion G protein-coupled receptor B3 GO:0004930,GO:0005096,GO:0005886,GO:0007166,GO:0007186,GO:0007520,GO:0016021,GO:0016322,GO:0016525,GO:0043083,GO:0048814,GO:0051965,GO:0061743,GO:0098794,GO:0099558 G-protein coupled receptor activity|GTPase activator activity|plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|myoblast fusion|integral component of membrane|neuron remodeling|negative regulation of angiogenesis|synaptic cleft|regulation of dendrite morphogenesis|positive regulation of synapse assembly|motor learning|postsynapse|maintenance of synapse structure ADGRD1 2.00831188251439 4.01662376502878 0 0 -Inf 0.119713491089471 1 0.00951281 0.0211251 0 0 GeneID:283383,Genbank:NM_001330497.1,HGNC:HGNC:19893,MIM:613639 adhesion G protein-coupled receptor D1 GO:0004930,GO:0005622,GO:0005886,GO:0007166,GO:0007186,GO:0007189,GO:0016021 G-protein coupled receptor activity|intracellular|plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|integral component of membrane ADGRE1 7.28789347445095 8.27337890348227 6.30240804541962 0.761769540467551 -0.392573492329969 0.779478665200465 1 0.105823 0.0650328 0.10034 0.0413601 GeneID:2015,Genbank:NM_001974.4,HGNC:HGNC:3336,MIM:600493 adhesion G protein-coupled receptor E1 GO:0002250,GO:0004930,GO:0005509,GO:0005887,GO:0007155,GO:0007166,GO:0007186,GO:0009897 adaptive immune response|G-protein coupled receptor activity|calcium ion binding|integral component of plasma membrane|cell adhesion|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|external side of plasma membrane ADGRE2 10.5378554229711 3.13253351048394 17.9431773354583 5.72800810443247 2.51803353384104 0.250240197295445 1 0.0163131 0 0.00514173 0.00479998 GeneID:30817,Genbank:NM_013447.3,HGNC:HGNC:3337,MIM:606100 adhesion G protein-coupled receptor E2 GO:0004930,GO:0005509,GO:0005886,GO:0006954,GO:0007155,GO:0007166,GO:0007186,GO:0016021,GO:0016477,GO:0031256,GO:0032587,GO:0035374,GO:0043304,GO:0071621 G-protein coupled receptor activity|calcium ion binding|plasma membrane|inflammatory response|cell adhesion|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|integral component of membrane|cell migration|leading edge membrane|ruffle membrane|chondroitin sulfate binding|regulation of mast cell degranulation|granulocyte chemotaxis ADGRE5 3483.09110267143 3311.1055709495 3655.07663439337 1.10388405204043 0.142588644642278 0.308183394733672 1 34.2081 37.6904 41.3105 39.6523 GeneID:976,Genbank:NM_078481.3,HGNC:HGNC:1711,MIM:601211 adhesion G protein-coupled receptor E5 ADGRF1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00657932 0 0 0 GeneID:266977,Genbank:NM_153840.3,HGNC:HGNC:18990,MIM:617430 adhesion G protein-coupled receptor F1 GO:0004930,GO:0005576,GO:0005622,GO:0005886,GO:0007166,GO:0007186,GO:0007189,GO:0007416,GO:0007613,GO:0016021,GO:0031175,GO:0032793 G-protein coupled receptor activity|extracellular region|intracellular|plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|synapse assembly|memory|integral component of membrane|neuron projection development|positive regulation of CREB transcription factor activity ADGRF2 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0143284 GeneID:222611,Genbank:NM_153839.6,HGNC:HGNC:18991 adhesion G protein-coupled receptor F2 GO:0004930,GO:0007166,GO:0007186,GO:0016021 G-protein coupled receptor activity|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|integral component of membrane ADGRF3 4.7005273036379 4.55472144167109 4.84633316560471 1.06402405233077 0.0895307634200427 1 1 0.00653932 0.0175254 0 0.0114577 GeneID:165082,Genbank:NM_153835.3,HGNC:HGNC:18989 adhesion G protein-coupled receptor F3 GO:0004930,GO:0007166,GO:0007186,GO:0016021 G-protein coupled receptor activity|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|integral component of membrane ADGRG1 1749.90995924171 1780.34004135481 1719.47987712861 0.965815426933898 -0.0501805870785125 0.711901703615966 1 14.1125 14.6023 14.6712 13.9665 GeneID:9289,Genbank:XM_006721340.3,HGNC:HGNC:4512,MIM:604110 adhesion G protein-coupled receptor G1 GO:0001525,GO:0004930,GO:0005518,GO:0005622,GO:0005887,GO:0007155,GO:0007166,GO:0007186,GO:0007266,GO:0007267,GO:0007420,GO:0008201,GO:0008285,GO:0010573,GO:0016021,GO:0016477,GO:0021796,GO:0021801,GO:0021819,GO:0035025,GO:0045121,GO:0045785,GO:0050840,GO:0070062,GO:0070528,GO:0072520,GO:0097451,GO:2000179,GO:2001223 angiogenesis|G-protein coupled receptor activity|collagen binding|intracellular|integral component of plasma membrane|cell adhesion|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|Rho protein signal transduction|cell-cell signaling|brain development|heparin binding|negative regulation of cell proliferation|vascular endothelial growth factor production|integral component of membrane|cell migration|cerebral cortex regionalization|cerebral cortex radial glia guided migration|layer formation in cerebral cortex|positive regulation of Rho protein signal transduction|membrane raft|positive regulation of cell adhesion|extracellular matrix binding|extracellular exosome|protein kinase C signaling|seminiferous tubule development|glial limiting end-foot|positive regulation of neural precursor cell proliferation|negative regulation of neuron migration ADGRG2 155.853933798763 147.412388437232 164.295479160293 1.11452965996986 0.15643501024689 0.519690174199448 1 0.93889 0.810679 1.039 0.988675 GeneID:10149,Genbank:XM_006724455.3,HGNC:HGNC:4516,MIM:300572 adhesion G protein-coupled receptor G2 GO:0004930,GO:0005829,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007283,GO:0009986,GO:0016021,GO:0016324,GO:0070062 G-protein coupled receptor activity|cytosol|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|spermatogenesis|cell surface|integral component of membrane|apical plasma membrane|extracellular exosome ADGRG3 2.53803493804801 3.6226049124413 1.45346496365472 0.401220944261132 -1.31753117639242 0.585743889120145 1 0.0487881 0.0146686 0.0229179 0.0224856 GeneID:222487,Genbank:XM_011522951.3,HGNC:HGNC:13728 adhesion G protein-coupled receptor G3 GO:0004930,GO:0005886,GO:0007166,GO:0007186,GO:0016021,GO:0030183,GO:0030334,GO:0032792,GO:0035579,GO:0043312,GO:1901223 G-protein coupled receptor activity|plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|integral component of membrane|B cell differentiation|regulation of cell migration|negative regulation of CREB transcription factor activity|specific granule membrane|neutrophil degranulation|negative regulation of NIK/NF-kappaB signaling ADGRG4 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0.00327433 0 GeneID:139378,Genbank:NM_153834.3,HGNC:HGNC:18992 adhesion G protein-coupled receptor G4 GO:0004930,GO:0007166,GO:0007186,GO:0016021 G-protein coupled receptor activity|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|integral component of membrane ADGRG5 3.2391227049012 3.084507235799 3.3937381740034 1.10025294627791 0.137835235013391 1 1 0.0311195 0.0276757 0.0485132 0.0181838 GeneID:221188,Genbank:XM_011522949.2,HGNC:HGNC:19010,MIM:616965 adhesion G protein-coupled receptor G5 GO:0004930,GO:0005886,GO:0007166,GO:0007186,GO:0016021 G-protein coupled receptor activity|plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|integral component of membrane ADGRG6 63.3536330099612 59.3358402555631 67.3714257643594 1.13542549451034 0.183233040939543 0.612212900121446 1 0.29821 0.255539 0.388623 0.257805 GeneID:57211,Genbank:NM_020455.5,HGNC:HGNC:13841,MIM:612243 adhesion G protein-coupled receptor G6 GO:0004930,GO:0005518,GO:0005622,GO:0005886,GO:0007005,GO:0007166,GO:0007186,GO:0007189,GO:0014037,GO:0016021,GO:0019933,GO:0022011,GO:0042552,GO:0043236,GO:0050840,GO:0060347 G-protein coupled receptor activity|collagen binding|intracellular|plasma membrane|mitochondrion organization|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|Schwann cell differentiation|integral component of membrane|cAMP-mediated signaling|myelination in peripheral nervous system|myelination|laminin binding|extracellular matrix binding|heart trabecula formation ADGRL1 1484.87144401568 1430.47439698281 1539.26849104854 1.07605455525468 0.105751223433719 0.485674149741439 1 5.49355 5.96496 6.94771 5.79409 GeneID:22859,Genbank:XM_005259818.3,HGNC:HGNC:20973,MIM:616416 adhesion G protein-coupled receptor L1 GO:0004930,GO:0005622,GO:0005886,GO:0007157,GO:0007166,GO:0007186,GO:0016021,GO:0016524,GO:0030054,GO:0030246,GO:0030424,GO:0030426,GO:0035584,GO:0042734,GO:0043005,GO:0045202,GO:0050839,GO:0051965,GO:0090129 G-protein coupled receptor activity|intracellular|plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|integral component of membrane|latrotoxin receptor activity|cell junction|carbohydrate binding|axon|growth cone|calcium-mediated signaling using intracellular calcium source|presynaptic membrane|neuron projection|synapse|cell adhesion molecule binding|positive regulation of synapse assembly|positive regulation of synapse maturation ADGRL2 531.813908880138 474.216267952763 589.411549807514 1.24291718702958 0.313730175841883 0.313252912117023 1 1.79773 1.6092 2.61555 1.73717 GeneID:23266,Genbank:XM_024454350.1,HGNC:HGNC:18582,MIM:607018 adhesion G protein-coupled receptor L2 ADGRL3 116.553769059668 111.936159398417 121.171378720919 1.08250434329832 0.114372813443799 0.709017618601118 1 0.21787 0.253522 0.289274 0.207647 GeneID:23284,Genbank:NM_001322402.1,HGNC:HGNC:20974,MIM:616417 adhesion G protein-coupled receptor L3 GO:0001764,GO:0004930,GO:0005509,GO:0005887,GO:0005911,GO:0007166,GO:0007186,GO:0007416,GO:0016021,GO:0030246,GO:0030424,GO:0031987,GO:0042220,GO:0051965,GO:0098742 neuron migration|G-protein coupled receptor activity|calcium ion binding|integral component of plasma membrane|cell-cell junction|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|synapse assembly|integral component of membrane|carbohydrate binding|axon|locomotion involved in locomotory behavior|response to cocaine|positive regulation of synapse assembly|cell-cell adhesion via plasma-membrane adhesion molecules ADGRV1 121.860458524503 131.269458137963 112.451458911044 0.856646020377861 -0.223228911719218 0.420323376046266 1 0.222348 0.238428 0.240618 0.158967 GeneID:84059,Genbank:XM_017009967.1,HGNC:HGNC:17416,MIM:602851 adhesion G protein-coupled receptor V1 GO:0004930,GO:0005509,GO:0005737,GO:0005886,GO:0007166,GO:0007186,GO:0007399,GO:0007601,GO:0007605,GO:0009986,GO:0016020,GO:0016021,GO:0032420,GO:0043235,GO:0045202,GO:0045494,GO:0048496,GO:0050877,GO:0050953,GO:0070062,GO:0098609 G-protein coupled receptor activity|calcium ion binding|cytoplasm|plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|nervous system development|visual perception|sensory perception of sound|cell surface|membrane|integral component of membrane|stereocilium|receptor complex|synapse|photoreceptor cell maintenance|maintenance of animal organ identity|nervous system process|sensory perception of light stimulus|extracellular exosome|cell-cell adhesion ADH1C 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:126,Genbank:NM_000669.4,HGNC:HGNC:251,MIM:103730 alcohol dehydrogenase 1C (class I), gamma polypeptide hsa00010,hsa00071,hsa00350,hsa00830,hsa00980,hsa00982,hsa05204 Glycolysis / Gluconeogenesis|Fatty acid degradation|Tyrosine metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ADH5 2643.20710160901 2682.25401169396 2604.16019152406 0.970885002005988 -0.0426276713961841 0.80078407606783 1 43.1198 43.0634 38.1247 44.6992 GeneID:128,Genbank:NM_000671.4,HGNC:HGNC:253,MIM:103710 alcohol dehydrogenase 5 (class III), chi polypeptide hsa00010,hsa00071,hsa00350,hsa00830,hsa00980,hsa00982,hsa05204 Glycolysis / Gluconeogenesis|Fatty acid degradation|Tyrosine metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ADH6 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0 0 0 0 GeneID:130,Genbank:NM_001102470.1,HGNC:HGNC:255,MIM:103735 alcohol dehydrogenase 6 (class V) GO:0004022,GO:0005737,GO:0008270 alcohol dehydrogenase (NAD) activity|cytoplasm|zinc ion binding hsa00010,hsa00071,hsa00350,hsa00830,hsa00980,hsa00982,hsa05204 Glycolysis / Gluconeogenesis|Fatty acid degradation|Tyrosine metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ADHFE1 16.5148281605971 7.83133377620985 25.1983225449843 3.2176284736493 1.68599775360414 0.0183045983485349 0.552102537005903 0.172713 0.0449941 0.372473 0.563335 GeneID:137872,Genbank:NM_144650.2,HGNC:HGNC:16354,MIM:611083 alcohol dehydrogenase, iron containing 1 GO:0004022,GO:0005739,GO:0005759,GO:0005829,GO:0006103,GO:0015993,GO:0046872,GO:0047988 alcohol dehydrogenase (NAD) activity|mitochondrion|mitochondrial matrix|cytosol|2-oxoglutarate metabolic process|molecular hydrogen transport|metal ion binding|hydroxyacid-oxoacid transhydrogenase activity ADI1 3851.56923771051 3700.26215437149 4002.87632104953 1.08178181816673 0.113409554997166 0.413025384740873 1 26.2001 29.4884 29.3902 30.7468 GeneID:55256,Genbank:NM_018269.3,HGNC:HGNC:30576,MIM:613400 acireductone dioxygenase 1 GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0010309,GO:0016491,GO:0019509,GO:0046872 nucleus|cytoplasm|cytosol|plasma membrane|acireductone dioxygenase [iron(II)-requiring] activity|oxidoreductase activity|L-methionine salvage from methylthioadenosine|metal ion binding hsa00270 Cysteine and methionine metabolism ADIPOQ 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00960139 0 GeneID:9370,Genbank:NM_001177800.1,HGNC:HGNC:13633,MIM:605441 adiponectin, C1Q and collagen domain containing hsa03320,hsa04152,hsa04211,hsa04920,hsa04930,hsa04932 PPAR signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Non-alcoholic fatty liver disease (NAFLD) ADIPOR1 4555.57313621354 4592.47481722428 4518.67145520279 0.983929500986116 -0.0233731454014706 0.839179940831256 1 65.7777 71.5814 70.248 67.9281 GeneID:51094,Genbank:NM_001290629.1,HGNC:HGNC:24040,MIM:607945 adiponectin receptor 1 hsa04152,hsa04211,hsa04920,hsa04932 AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease (NAFLD) ADIPOR2 2354.86378701305 2285.09360670723 2424.63396731887 1.06106548992219 0.0855137034441473 0.540396766984143 1 21.9865 22.5327 24.8698 22.8335 GeneID:79602,Genbank:XM_005253789.2,HGNC:HGNC:24041,MIM:607946 adiponectin receptor 2 hsa04152,hsa04211,hsa04920,hsa04932 AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease (NAFLD) ADIRF 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0.160123 0 0 0 GeneID:10974,Genbank:NM_006829.2,HGNC:HGNC:24043 adipogenesis regulatory factor ADK 1239.28647348186 1322.23524373428 1156.33770322945 0.874532507516361 -0.193416082883378 0.198029531260433 1 6.7346 6.31991 6.03581 5.49235 GeneID:132,Genbank:NM_006721.3,HGNC:HGNC:257,MIM:102750 adenosine kinase GO:0003723,GO:0004001,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006169,GO:0006175,GO:0009156,GO:0043101,GO:0044209,GO:0046872 RNA binding|adenosine kinase activity|ATP binding|nucleus|nucleoplasm|cytosol|adenosine salvage|dATP biosynthetic process|ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage|AMP salvage|metal ion binding hsa00230 Purine metabolism ADM 264.705940825469 248.798316711758 280.61356493918 1.12787565706998 0.173608026232693 0.423651612226469 1 7.63968 8.84157 10.4018 8.90926 GeneID:133,Genbank:NM_001124.2,HGNC:HGNC:259,MIM:103275 adrenomedullin hsa04270 Vascular smooth muscle contraction ADM5 27.4866317708369 24.9259979149246 30.0472656267492 1.20545888390523 0.269582443974346 0.65755206676618 1 0.481564 0.652241 0.649081 0.610892 GeneID:199800,Genbank:NM_001101340.1,HGNC:HGNC:27293 adrenomedullin 5 (putative) GO:0005576 extracellular region ADNP 1744.53828226364 1795.15480227055 1693.92176225672 0.943607626547982 -0.0837410159258321 0.56832253806364 1 8.78884 8.5518 9.14154 7.22751 GeneID:23394,Genbank:NM_181442.3,HGNC:HGNC:15766,MIM:611386 activity dependent neuroprotector homeobox GO:0003677,GO:0003682,GO:0005507,GO:0005615,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0007614,GO:0009743,GO:0010035,GO:0010629,GO:0010835,GO:0030424,GO:0030425,GO:0030828,GO:0031668,GO:0032091,GO:0032147,GO:0033484,GO:0042277,GO:0043025,GO:0043524,GO:0044849,GO:0045773,GO:0048487,GO:0050731,GO:0050805,GO:0051965 DNA binding|chromatin binding|copper ion binding|extracellular space|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|short-term memory|response to carbohydrate|response to inorganic substance|negative regulation of gene expression|regulation of protein ADP-ribosylation|axon|dendrite|positive regulation of cGMP biosynthetic process|cellular response to extracellular stimulus|negative regulation of protein binding|activation of protein kinase activity|nitric oxide homeostasis|peptide binding|neuronal cell body|negative regulation of neuron apoptotic process|estrous cycle|positive regulation of axon extension|beta-tubulin binding|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of synaptic transmission|positive regulation of synapse assembly ADNP2 480.353544713438 499.29615334685 461.410936080025 0.924122753574456 -0.113843593667519 0.533973519258057 1 4.00305 3.63449 3.97793 3.11313 GeneID:22850,Genbank:NM_014913.3,HGNC:HGNC:23803,MIM:617422 ADNP homeobox 2 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0030182,GO:0030307,GO:0034599,GO:0046872,GO:0060548,GO:0071300 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|neuron differentiation|positive regulation of cell growth|cellular response to oxidative stress|metal ion binding|negative regulation of cell death|cellular response to retinoic acid ADO 1189.90455944103 1229.30702480858 1150.50209407349 0.935894834126278 -0.0955816706434638 0.521052407217444 1 17.6216 18.0573 17.2694 16.6428 GeneID:84890,Genbank:NM_032804.5,HGNC:HGNC:23506,MIM:611392 2-aminoethanethiol dioxygenase GO:0000098,GO:0005739,GO:0005829,GO:0046872,GO:0047800,GO:0055114 sulfur amino acid catabolic process|mitochondrion|cytosol|metal ion binding|cysteamine dioxygenase activity|oxidation-reduction process hsa00430 Taurine and hypotaurine metabolism ADORA1 160.461584051263 152.284693492336 168.63847461019 1.10738952643771 0.147162782202334 0.573739921785606 1 1.92899 2.17281 2.16171 2.49484 GeneID:134,Genbank:XM_005244901.1,HGNC:HGNC:262,MIM:102775 adenosine A1 receptor GO:0000186,GO:0001609,GO:0001659,GO:0001664,GO:0001666,GO:0001883,GO:0002087,GO:0002674,GO:0002686,GO:0002793,GO:0003093,GO:0004629,GO:0005783,GO:0005886,GO:0005887,GO:0006612,GO:0006909,GO:0006954,GO:0007165,GO:0007186,GO:0007193,GO:0007267,GO:0007399,GO:0008285,GO:0014050,GO:0014069,GO:0016042,GO:0016323,GO:0030673,GO:0031072,GO:0031683,GO:0032229,GO:0032244,GO:0032795,GO:0032900,GO:0035307,GO:0035814,GO:0042323,GO:0043025,GO:0043066,GO:0043195,GO:0043197,GO:0043268,GO:0045741,GO:0045776,GO:0045777,GO:0046888,GO:0046982,GO:0048786,GO:0050890,GO:0050965,GO:0050995,GO:0051930,GO:0051967,GO:0055118,GO:0060079,GO:0060087,GO:0070256,GO:0097190,GO:0097756,GO:0099055,GO:0099056,GO:1900453 activation of MAPKK activity|G-protein coupled adenosine receptor activity|temperature homeostasis|G-protein coupled receptor binding|response to hypoxia|purine nucleoside binding|regulation of respiratory gaseous exchange by neurological system process|negative regulation of acute inflammatory response|negative regulation of leukocyte migration|positive regulation of peptide secretion|regulation of glomerular filtration|phospholipase C activity|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|protein targeting to membrane|phagocytosis|inflammatory response|signal transduction|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|cell-cell signaling|nervous system development|negative regulation of cell proliferation|negative regulation of glutamate secretion|postsynaptic density|lipid catabolic process|basolateral plasma membrane|axolemma|heat shock protein binding|G-protein beta/gamma-subunit complex binding|negative regulation of synaptic transmission, GABAergic|positive regulation of nucleoside transport|heterotrimeric G-protein binding|negative regulation of neurotrophin production|positive regulation of protein dephosphorylation|negative regulation of renal sodium excretion|negative regulation of circadian sleep/wake cycle, non-REM sleep|neuronal cell body|negative regulation of apoptotic process|terminal bouton|dendritic spine|positive regulation of potassium ion transport|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of blood pressure|positive regulation of blood pressure|negative regulation of hormone secretion|protein heterodimerization activity|presynaptic active zone|cognition|detection of temperature stimulus involved in sensory perception of pain|negative regulation of lipid catabolic process|regulation of sensory perception of pain|negative regulation of synaptic transmission, glutamatergic|negative regulation of cardiac muscle contraction|excitatory postsynaptic potential|relaxation of vascular smooth muscle|negative regulation of mucus secretion|apoptotic signaling pathway|negative regulation of blood vessel diameter|integral component of postsynaptic membrane|integral component of presynaptic membrane|negative regulation of long term synaptic depression hsa04022,hsa04024,hsa04071,hsa04080,hsa04923,hsa04924,hsa05032 cGMP-PKG signaling pathway|cAMP signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction|Regulation of lipolysis in adipocytes|Renin secretion|Morphine addiction ADORA2A 47.9144439439522 49.304089498099 46.5247983898053 0.943629602806052 -0.0837074165054268 0.867710332667884 1 0.865211 0.800776 0.802041 0.682806 GeneID:135,Genbank:NM_001278500.1,HGNC:HGNC:263,MIM:102776 adenosine A2a receptor GO:0001609,GO:0001963,GO:0001975,GO:0005882,GO:0005886,GO:0005887,GO:0006171,GO:0006355,GO:0006469,GO:0006909,GO:0006915,GO:0006954,GO:0006968,GO:0007186,GO:0007188,GO:0007189,GO:0007205,GO:0007267,GO:0007271,GO:0007417,GO:0007596,GO:0007600,GO:0007626,GO:0008015,GO:0008285,GO:0012505,GO:0014049,GO:0014057,GO:0014061,GO:0014069,GO:0016020,GO:0019899,GO:0030425,GO:0030673,GO:0031000,GO:0031802,GO:0032230,GO:0035249,GO:0035810,GO:0035815,GO:0040013,GO:0042311,GO:0042755,GO:0042802,GO:0043025,GO:0043116,GO:0043154,GO:0043524,GO:0044267,GO:0045938,GO:0046636,GO:0046982,GO:0048143,GO:0048167,GO:0048786,GO:0048812,GO:0050714,GO:0050728,GO:0051393,GO:0051881,GO:0051899,GO:0051924,GO:0051968,GO:0060079,GO:0060080,GO:0060134,GO:0099055,GO:0099056,GO:2001235 G-protein coupled adenosine receptor activity|synaptic transmission, dopaminergic|response to amphetamine|intermediate filament|plasma membrane|integral component of plasma membrane|cAMP biosynthetic process|regulation of transcription, DNA-templated|negative regulation of protein kinase activity|phagocytosis|apoptotic process|inflammatory response|cellular defense response|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|protein kinase C-activating G-protein coupled receptor signaling pathway|cell-cell signaling|synaptic transmission, cholinergic|central nervous system development|blood coagulation|sensory perception|locomotory behavior|blood circulation|negative regulation of cell proliferation|endomembrane system|positive regulation of glutamate secretion|positive regulation of acetylcholine secretion, neurotransmission|regulation of norepinephrine secretion|postsynaptic density|membrane|enzyme binding|dendrite|axolemma|response to caffeine|type 5 metabotropic glutamate receptor binding|positive regulation of synaptic transmission, GABAergic|synaptic transmission, glutamatergic|positive regulation of urine volume|positive regulation of renal sodium excretion|negative regulation of locomotion|vasodilation|eating behavior|identical protein binding|neuronal cell body|negative regulation of vascular permeability|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of neuron apoptotic process|cellular protein metabolic process|positive regulation of circadian sleep/wake cycle, sleep|negative regulation of alpha-beta T cell activation|protein heterodimerization activity|astrocyte activation|regulation of synaptic plasticity|presynaptic active zone|neuron projection morphogenesis|positive regulation of protein secretion|negative regulation of inflammatory response|alpha-actinin binding|regulation of mitochondrial membrane potential|membrane depolarization|regulation of calcium ion transport|positive regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|inhibitory postsynaptic potential|prepulse inhibition|integral component of postsynaptic membrane|integral component of presynaptic membrane|positive regulation of apoptotic signaling pathway hsa04015,hsa04020,hsa04024,hsa04080,hsa04270,hsa05012,hsa05034 Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Parkinson disease|Alcoholism ADORA2B 2169.8403623353 2114.76353223759 2224.91719243302 1.05208793253536 0.073255288785282 0.604902020758432 1 12.1193 12.4943 13.0261 12.99 GeneID:136,Genbank:XM_011523659.3,HGNC:HGNC:264,MIM:600446 adenosine A2b receptor GO:0000187,GO:0001609,GO:0002882,GO:0005622,GO:0005886,GO:0005887,GO:0006968,GO:0007186,GO:0007189,GO:0007190,GO:0007254,GO:0007588,GO:0010575,GO:0031284,GO:0031668,GO:0032722,GO:0032755,GO:0043306,GO:0044267,GO:0060087 activation of MAPK activity|G-protein coupled adenosine receptor activity|positive regulation of chronic inflammatory response to non-antigenic stimulus|intracellular|plasma membrane|integral component of plasma membrane|cellular defense response|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|JNK cascade|excretion|positive regulation of vascular endothelial growth factor production|positive regulation of guanylate cyclase activity|cellular response to extracellular stimulus|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of mast cell degranulation|cellular protein metabolic process|relaxation of vascular smooth muscle hsa04015,hsa04020,hsa04080,hsa04270,hsa05034 Rap1 signaling pathway|Calcium signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Alcoholism ADORA3 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0374712 GeneID:140,Genbank:NM_001302679.1,HGNC:HGNC:268,MIM:600445 adenosine A3 receptor GO:0001609,GO:0005886,GO:0005887,GO:0006954,GO:0007165,GO:0007186,GO:0007190,GO:0008016,GO:0008285,GO:0009611,GO:0030336,GO:0032088 G-protein coupled adenosine receptor activity|plasma membrane|integral component of plasma membrane|inflammatory response|signal transduction|G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|regulation of heart contraction|negative regulation of cell proliferation|response to wounding|negative regulation of cell migration|negative regulation of NF-kappaB transcription factor activity hsa04022,hsa04071,hsa04080 cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction ADPGK 1853.90007900073 1895.30287305923 1812.49728494224 0.956310102573036 -0.0644495782504246 0.637743458553638 1 12.4047 13.6736 12.7035 12.0602 GeneID:83440,Genbank:NM_031284.4,HGNC:HGNC:25250,MIM:611861 ADP dependent glucokinase GO:0005576,GO:0005783,GO:0005789,GO:0006006,GO:0016020,GO:0043843,GO:0046872,GO:0061621 extracellular region|endoplasmic reticulum|endoplasmic reticulum membrane|glucose metabolic process|membrane|ADP-specific glucokinase activity|metal ion binding|canonical glycolysis hsa00010 Glycolysis / Gluconeogenesis ADPRH 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0119576 0 0 GeneID:141,Genbank:XM_011512438.2,HGNC:HGNC:269,MIM:603081 ADP-ribosylarginine hydrolase GO:0000287,GO:0003875,GO:0005622,GO:0006464,GO:0030955,GO:0051725 magnesium ion binding|ADP-ribosylarginine hydrolase activity|intracellular|cellular protein modification process|potassium ion binding|protein de-ADP-ribosylation ADPRHL1 14.1491731995719 13.7602168743831 14.5381295247607 1.05653345855513 0.0793384556090955 0.979041925323246 1 0.181466 0.195089 0.225267 0.192755 GeneID:113622,Genbank:NM_138430.4,HGNC:HGNC:21303,MIM:610620 ADP-ribosylhydrolase like 1 GO:0000287,GO:0003875,GO:0005096,GO:0005622,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0051725,GO:0090630 magnesium ion binding|ADP-ribosylarginine hydrolase activity|GTPase activator activity|intracellular|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|protein de-ADP-ribosylation|activation of GTPase activity ADPRHL2 998.392867764835 996.970239010376 999.815496519294 1.0028539041564 0.00411144931905199 1 1 26.8635 28.3796 30.1033 26.3066 GeneID:54936,Genbank:NM_017825.2,HGNC:HGNC:21304,MIM:610624 ADP-ribosylhydrolase like 2 GO:0004649,GO:0005654,GO:0005759,GO:0016604,GO:0046872,GO:0071451 poly(ADP-ribose) glycohydrolase activity|nucleoplasm|mitochondrial matrix|nuclear body|metal ion binding|cellular response to superoxide ADPRM 86.0204832293958 94.9855740837568 77.0553923750349 0.811232580508369 -0.301812500245856 0.348904265732199 1 2.21777 2.44308 1.96873 1.91173 GeneID:56985,Genbank:NM_020233.4,HGNC:HGNC:30925 ADP-ribose/CDP-alcohol diphosphatase, manganese dependent GO:0005829,GO:0034656,GO:0046872,GO:0047631,GO:0047734 cytosol|nucleobase-containing small molecule catabolic process|metal ion binding|ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity hsa00230,hsa00564 Purine metabolism|Glycerophospholipid metabolism ADRA1B 382.973954746147 325.882588642264 440.065320850029 1.35037997176679 0.433365411907289 0.0228199526679874 0.613376998591817 0.941316 1.27626 1.53085 1.34666 GeneID:147,Genbank:NM_000679.3,HGNC:HGNC:278,MIM:104220 adrenoceptor alpha 1B GO:0001994,GO:0004937,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0005901,GO:0007186,GO:0007188,GO:0007200,GO:0007204,GO:0007267,GO:0007275,GO:0008283,GO:0031965,GO:0035556,GO:0042593,GO:0043410,GO:0045907,GO:0045987,GO:0046982,GO:0055117,GO:0071880 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure|alpha1-adrenergic receptor activity|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|caveola|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|multicellular organism development|cell proliferation|nuclear membrane|intracellular signal transduction|glucose homeostasis|positive regulation of MAPK cascade|positive regulation of vasoconstriction|positive regulation of smooth muscle contraction|protein heterodimerization activity|regulation of cardiac muscle contraction|adenylate cyclase-activating adrenergic receptor signaling pathway hsa04020,hsa04022,hsa04080,hsa04261,hsa04270,hsa04970 Calcium signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion ADRA1D 266.580594984455 228.321179034027 304.840010934884 1.33513681133126 0.416987582299492 0.0459648623686648 0.79332376136203 4.51711 4.89377 7.29965 6.5691 GeneID:146,Genbank:NM_000678.3,HGNC:HGNC:280,MIM:104219 adrenoceptor alpha 1D GO:0001994,GO:0004937,GO:0005622,GO:0005886,GO:0005887,GO:0006259,GO:0007186,GO:0007188,GO:0007200,GO:0007204,GO:0007267,GO:0007275,GO:0008283,GO:0008284,GO:0045907,GO:0045987,GO:0071880 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure|alpha1-adrenergic receptor activity|intracellular|plasma membrane|integral component of plasma membrane|DNA metabolic process|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|multicellular organism development|cell proliferation|positive regulation of cell proliferation|positive regulation of vasoconstriction|positive regulation of smooth muscle contraction|adenylate cyclase-activating adrenergic receptor signaling pathway hsa04020,hsa04022,hsa04080,hsa04261,hsa04270,hsa04970 Calcium signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Salivary secretion ADRA2A 1.73926304419324 3.47852608838648 0 0 -Inf 0.165113950009275 1 0.0189707 0.098322 0 0 GeneID:150,Genbank:NM_000681.3,HGNC:HGNC:281,MIM:104210 adrenoceptor alpha 2A hsa04022,hsa04080 cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction ADRB1 13.1256806007909 12.1939501191412 14.0574110824406 1.15281848335383 0.205165371809491 0.855576741778206 1 0.212567 0.315233 0.399674 0.227623 GeneID:153,Genbank:NM_000684.2,HGNC:HGNC:285,MIM:109630 adrenoceptor beta 1 hsa04020,hsa04022,hsa04024,hsa04080,hsa04261,hsa04540,hsa04923,hsa04924,hsa04970,hsa05414 Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Gap junction|Regulation of lipolysis in adipocytes|Renin secretion|Salivary secretion|Dilated cardiomyopathy (DCM) ADRB2 39.9141740466812 42.9909962024462 36.8373518909162 0.856862021001973 -0.222865186515296 0.63350826845752 1 0.806214 1.05934 1.04724 0.710953 GeneID:154,Genbank:NM_000024.5,HGNC:HGNC:286,MIM:109690 adrenoceptor beta 2 hsa04020,hsa04022,hsa04024,hsa04080,hsa04261,hsa04923,hsa04924,hsa04970 Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Regulation of lipolysis in adipocytes|Renin secretion|Salivary secretion ADRM1 4454.37210231235 4422.2134033404 4486.5308012843 1.0145441642177 0.0208316685554276 0.908050164190463 1 66.0972 71.4698 68.3567 71.2786 GeneID:11047,Genbank:XM_017027602.1,HGNC:HGNC:15759,MIM:610650 adhesion regulating molecule 1 GO:0000502,GO:0002020,GO:0005654,GO:0005829,GO:0005886,GO:0005887,GO:0006368,GO:0006511,GO:0008541,GO:0016020,GO:0016579,GO:0043130,GO:0043248,GO:0061133,GO:0070628 proteasome complex|protease binding|nucleoplasm|cytosol|plasma membrane|integral component of plasma membrane|transcription elongation from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|proteasome regulatory particle, lid subcomplex|membrane|protein deubiquitination|ubiquitin binding|proteasome assembly|endopeptidase activator activity|proteasome binding hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection ADSL 2043.24305130182 2063.71189654147 2022.77420606217 0.980163078699161 -0.0289062913154125 0.820558352202141 1 16.189 18.0179 16.6786 16.87 GeneID:158,Genbank:NM_000026.3,HGNC:HGNC:291,MIM:608222 adenylosuccinate lyase hsa00230,hsa00250 Purine metabolism|Alanine, aspartate and glutamate metabolism ADSS 943.839364471904 1042.44777584048 845.230953103331 0.81081371430992 -0.30255760376437 0.052996186259939 0.840383088256616 10.3059 9.74578 8.97188 7.91957 GeneID:159,Genbank:NM_001126.3,HGNC:HGNC:292,MIM:103060 adenylosuccinate synthase GO:0002376,GO:0004019,GO:0005525,GO:0005737,GO:0005829,GO:0005886,GO:0006167,GO:0006531,GO:0009168,GO:0014074,GO:0042301,GO:0044208,GO:0046040,GO:0046872,GO:0060359,GO:0070062,GO:0071257 immune system process|adenylosuccinate synthase activity|GTP binding|cytoplasm|cytosol|plasma membrane|AMP biosynthetic process|aspartate metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to purine-containing compound|phosphate ion binding|'de novo' AMP biosynthetic process|IMP metabolic process|metal ion binding|response to ammonium ion|extracellular exosome|cellular response to electrical stimulus hsa00230,hsa00250 Purine metabolism|Alanine, aspartate and glutamate metabolism ADSSL1 18.8572051522651 19.7851525219263 17.9292577826039 0.906197602608035 -0.142102420754305 0.846827306846874 1 0.1825 0.239037 0.153439 0.206765 GeneID:122622,Genbank:NM_152328.4,HGNC:HGNC:20093,MIM:612498 adenylosuccinate synthase like 1 GO:0002376,GO:0003924,GO:0004019,GO:0005525,GO:0005737,GO:0005829,GO:0006167,GO:0006531,GO:0006541,GO:0009168,GO:0014850,GO:0035690,GO:0042301,GO:0042594,GO:0042803,GO:0044208,GO:0046040,GO:0046872,GO:0051015,GO:0071257 immune system process|GTPase activity|adenylosuccinate synthase activity|GTP binding|cytoplasm|cytosol|AMP biosynthetic process|aspartate metabolic process|glutamine metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to muscle activity|cellular response to drug|phosphate ion binding|response to starvation|protein homodimerization activity|'de novo' AMP biosynthetic process|IMP metabolic process|metal ion binding|actin filament binding|cellular response to electrical stimulus hsa00230,hsa00250 Purine metabolism|Alanine, aspartate and glutamate metabolism ADTRP 25.7203235933091 26.242324641634 25.1983225449843 0.960216859180482 -0.058567828290409 0.961455377438674 1 0.115311 0.0832693 0.0895286 0.0735373 GeneID:84830,Genbank:XM_005249454.3,HGNC:HGNC:21214,MIM:614348 androgen dependent TFPI regulating protein GO:0005901,GO:0009986,GO:0010628,GO:0012505,GO:0016020,GO:0016021,GO:0016787,GO:0030195,GO:0042758,GO:0071383 caveola|cell surface|positive regulation of gene expression|endomembrane system|membrane|integral component of membrane|hydrolase activity|negative regulation of blood coagulation|long-chain fatty acid catabolic process|cellular response to steroid hormone stimulus AEBP1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00664554 GeneID:165,Genbank:XM_011515162.1,HGNC:HGNC:303,MIM:602981 AE binding protein 1 GO:0000122,GO:0000977,GO:0001227,GO:0001501,GO:0003700,GO:0003714,GO:0004180,GO:0004181,GO:0004185,GO:0005516,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0006351,GO:0006518,GO:0007517,GO:0008270,GO:0016485,GO:0070062 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|skeletal system development|DNA binding transcription factor activity|transcription corepressor activity|carboxypeptidase activity|metallocarboxypeptidase activity|serine-type carboxypeptidase activity|calmodulin binding|extracellular region|extracellular space|nucleus|cytoplasm|transcription, DNA-templated|peptide metabolic process|muscle organ development|zinc ion binding|protein processing|extracellular exosome AEBP2 388.885146621804 386.638582827305 391.131710416303 1.01162100159829 0.0166688932676041 0.927581116395512 1 2.80272 2.08708 2.79492 2.21955 GeneID:121536,Genbank:XM_017018806.1,HGNC:HGNC:24051 AE binding protein 2 GO:0000978,GO:0001078,GO:0003714,GO:0005634,GO:0005654,GO:0006351,GO:0016569,GO:0035098,GO:0045814,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcription corepressor activity|nucleus|nucleoplasm|transcription, DNA-templated|covalent chromatin modification|ESC/E(Z) complex|negative regulation of gene expression, epigenetic|metal ion binding AEN 1497.80224275512 1579.99013285107 1415.61435265916 0.895964046373319 -0.158487254523717 0.271159291000334 1 13.5001 13.67 12.681 11.7063 GeneID:64782,Genbank:XM_011521905.2,HGNC:HGNC:25722,MIM:610177 apoptosis enhancing nuclease GO:0003676,GO:0004527,GO:0005634,GO:0005654,GO:0005730,GO:0010212,GO:0031965,GO:0042771 nucleic acid binding|exonuclease activity|nucleus|nucleoplasm|nucleolus|response to ionizing radiation|nuclear membrane|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator AES 8688.67988087514 7151.10165046032 10226.25811129 1.4300255556613 0.51604092930883 8.92637709361709e-05 0.0217714797501036 145.469 151.924 211.234 215.775 GeneID:166,Genbank:XM_006722664.1,HGNC:HGNC:307,MIM:600188 amino-terminal enhancer of split GO:0000122,GO:0001501,GO:0003714,GO:0005634,GO:0006351,GO:0007275,GO:0009887,GO:0010629,GO:0016055,GO:0031668,GO:0032091,GO:0040008,GO:0045892,GO:0060761,GO:0070555,GO:0090090,GO:2000210 negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transcription corepressor activity|nucleus|transcription, DNA-templated|multicellular organism development|animal organ morphogenesis|negative regulation of gene expression|Wnt signaling pathway|cellular response to extracellular stimulus|negative regulation of protein binding|regulation of growth|negative regulation of transcription, DNA-templated|negative regulation of response to cytokine stimulus|response to interleukin-1|negative regulation of canonical Wnt signaling pathway|positive regulation of anoikis AFAP1 4064.98448803459 4055.74585588077 4074.22312018841 1.00455582399988 0.00655773805825919 0.96016064747067 1 19.2816 18.972 19.5708 19.229 GeneID:60312,Genbank:NM_198595.2,HGNC:HGNC:24017,MIM:608252 actin filament associated protein 1 GO:0003779,GO:0005829,GO:0005925,GO:0009966,GO:0015629,GO:0051493 actin binding|cytosol|focal adhesion|regulation of signal transduction|actin cytoskeleton|regulation of cytoskeleton organization AFAP1L1 77.9400535843171 69.1372682947103 86.7428388739239 1.25464660397293 0.327281057807429 0.331893972224016 1 0.259771 0.339883 0.401155 0.432479 GeneID:134265,Genbank:NM_152406.3,HGNC:HGNC:26714,MIM:614410 actin filament associated protein 1 like 1 GO:0002102,GO:0005737,GO:0030054,GO:0071437 podosome|cytoplasm|cell junction|invadopodium AFAP1L2 61.1217327528712 86.3858199125879 35.8576455931545 0.415087170897239 -1.26851375164483 0.00457733058580781 0.267556666650722 0.368438 0.526615 0.150376 0.195443 GeneID:84632,Genbank:XM_005270233.4,HGNC:HGNC:25901,MIM:612420 actin filament associated protein 1 like 2 GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007346,GO:0017124,GO:0030296,GO:0032675,GO:0032757,GO:0035591,GO:0042169,GO:0045742,GO:0045893 cytoplasm|cytosol|plasma membrane|inflammatory response|regulation of mitotic cell cycle|SH3 domain binding|protein tyrosine kinase activator activity|regulation of interleukin-6 production|positive regulation of interleukin-8 production|signaling adaptor activity|SH2 domain binding|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of transcription, DNA-templated AFDN 1555.60450144554 1502.06979694071 1609.13920595038 1.0712812475344 0.099337286023136 0.545375378037027 1 4.89176 4.92383 5.91849 4.49324 GeneID:4301,Genbank:XM_017010879.1,HGNC:HGNC:7137,MIM:159559 afadin, adherens junction formation factor hsa04014,hsa04015,hsa04024,hsa04520,hsa04530,hsa04670 Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Adherens junction|Tight junction|Leukocyte transendothelial migration AFF1 671.678305985743 634.678287799212 708.678324172273 1.11659456104866 0.159105433855574 0.649300696249958 1 2.2566 2.1093 3.12804 1.82316 GeneID:4299,Genbank:XM_005263009.4,HGNC:HGNC:7135,MIM:159557 AF4/FMR2 family member 1 hsa05202 Transcriptional misregulation in cancer AFF2 308.667152591949 311.967467287863 305.366837896034 0.978841930380712 -0.030852191818403 0.931935396507875 1 0.84331 0.749598 0.956879 0.627542 GeneID:2334,Genbank:NM_002025.3,HGNC:HGNC:3776,MIM:300806 AF4/FMR2 family member 2 GO:0002151,GO:0006397,GO:0007420,GO:0007611,GO:0008380,GO:0010468,GO:0010629,GO:0016607,GO:0035063,GO:0043484 G-quadruplex RNA binding|mRNA processing|brain development|learning or memory|RNA splicing|regulation of gene expression|negative regulation of gene expression|nuclear speck|nuclear speck organization|regulation of RNA splicing AFF3 137.36332197609 138.514667962845 136.211975989335 0.983375825770825 -0.0241852049202329 0.956890380455004 1 0.233076 0.239257 0.310027 0.167311 GeneID:3899,Genbank:XM_011511171.3,HGNC:HGNC:6473,MIM:601464 AF4/FMR2 family member 3 AFF4 2109.0198782412 2121.14020111473 2096.89955536767 0.988571879532376 -0.0165822260752543 0.972632175635174 1 8.34595 7.43547 9.83685 6.16168 GeneID:27125,Genbank:NM_014423.3,HGNC:HGNC:17869,MIM:604417 AF4/FMR2 family member 4 AFG1L 93.2992765094116 82.3976051120281 104.200947906795 1.26461136540465 0.338694090573656 0.264883429745855 1 0.307499 0.192426 0.393572 0.309929 GeneID:246269,Genbank:NM_145315.4,HGNC:HGNC:16411,MIM:617469 AFG1 like ATPase GO:0005524,GO:0005739,GO:0006123,GO:0007005,GO:0016787,GO:0031966,GO:0035694 ATP binding|mitochondrion|mitochondrial electron transport, cytochrome c to oxygen|mitochondrion organization|hydrolase activity|mitochondrial membrane|mitochondrial protein catabolic process AFG3L2 1713.40826850127 1652.64312785289 1774.17340914964 1.07353691746786 0.102371804361119 0.466304859113999 1 17.9674 17.364 19.0524 19.4525 GeneID:10939,Genbank:XM_011525601.3,HGNC:HGNC:315,MIM:604581 AFG3 like matrix AAA peptidase subunit 2 GO:0004222,GO:0005524,GO:0005739,GO:0005743,GO:0005745,GO:0006508,GO:0006851,GO:0007409,GO:0007528,GO:0008053,GO:0008237,GO:0008270,GO:0016485,GO:0016540,GO:0021675,GO:0034982,GO:0036444,GO:0040014,GO:0042407,GO:0042552,GO:0048747,GO:0051082,GO:0051560,GO:0060013 metalloendopeptidase activity|ATP binding|mitochondrion|mitochondrial inner membrane|m-AAA complex|proteolysis|mitochondrial calcium ion transmembrane transport|axonogenesis|neuromuscular junction development|mitochondrial fusion|metallopeptidase activity|zinc ion binding|protein processing|protein autoprocessing|nerve development|mitochondrial protein processing|mitochondrial calcium uptake|regulation of multicellular organism growth|cristae formation|myelination|muscle fiber development|unfolded protein binding|mitochondrial calcium ion homeostasis|righting reflex AFM 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0355703 GeneID:173,Genbank:NM_001133.2,HGNC:HGNC:316,MIM:104145 afamin GO:0005576,GO:0005615,GO:0008431,GO:0050821,GO:0051180,GO:0070062,GO:0071693,GO:0072562 extracellular region|extracellular space|vitamin E binding|protein stabilization|vitamin transport|extracellular exosome|protein transport within extracellular region|blood microparticle AFMID 510.457759147298 560.083607498924 460.831910795671 0.822791284418293 -0.281401582980159 0.105041656862531 1 4.50479 4.98092 3.67395 4.13358 GeneID:125061,Genbank:XM_011524329.2,HGNC:HGNC:20910 arylformamidase GO:0004061,GO:0005634,GO:0005737,GO:0005829,GO:0016787,GO:0019441 arylformamidase activity|nucleus|cytoplasm|cytosol|hydrolase activity|tryptophan catabolic process to kynurenine hsa00380,hsa00630 Tryptophan metabolism|Glyoxylate and dicarboxylate metabolism AFP 29.9290524570777 34.6597823691711 25.1983225449843 0.72701906424541 -0.459934899199579 0.399160264139081 1 0.576668 0.429385 0.357306 0.365337 GeneID:174,Genbank:NM_001134.2,HGNC:HGNC:317,MIM:104150 alpha fetoprotein hsa04390 Hippo signaling pathway AFTPH 380.330791966226 385.51537820019 375.146205732261 0.973103089904382 -0.0393354436163272 0.85226120738232 1 3.49288 3.43495 3.79137 2.87507 GeneID:54812,Genbank:NM_203437.3,HGNC:HGNC:25951 aftiphilin GO:0005634,GO:0005794,GO:0005829,GO:0015031,GO:0030121,GO:0030276,GO:0043231 nucleus|Golgi apparatus|cytosol|protein transport|AP-1 adaptor complex|clathrin binding|intracellular membrane-bounded organelle AGA 329.791059109842 301.475071093766 358.107047125919 1.18784961498372 0.248352198554099 0.208221609687887 1 5.06892 5.70558 5.91492 7.28249 GeneID:175,Genbank:NM_001171988.1,HGNC:HGNC:318,MIM:613228 aspartylglucosaminidase GO:0003948,GO:0005576,GO:0005615,GO:0005764,GO:0005783,GO:0006517,GO:0008233,GO:0035578,GO:0043312,GO:0043621,GO:0051604,GO:0070062 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity|extracellular region|extracellular space|lysosome|endoplasmic reticulum|protein deglycosylation|peptidase activity|azurophil granule lumen|neutrophil degranulation|protein self-association|protein maturation|extracellular exosome hsa00511,hsa04142 Other glycan degradation|Lysosome AGAP1 975.73135719893 981.700573309688 969.762141088171 0.987839028980834 -0.0176521249513676 0.910821026402332 1 2.05823 2.10804 2.09241 2.0042 GeneID:116987,Genbank:NM_001037131.2,HGNC:HGNC:16922,MIM:608651 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 GO:0003924,GO:0005096,GO:0005525,GO:0005543,GO:0005737,GO:0015031,GO:0046872 GTPase activity|GTPase activator activity|GTP binding|phospholipid binding|cytoplasm|protein transport|metal ion binding hsa04144 Endocytosis AGAP11 0.996216306175209 0.538097676642304 1.45433493570811 2.70273409241064 1.43441957978558 0.835201184388344 1 0.0114436 0 0.0217655 0.0101292 GeneID:119385,Genbank:NM_133447.1,HGNC:HGNC:29421 ArfGAP with GTPase domain, ankyrin repeat and PH domain 11 GO:0005096,GO:0046872 GTPase activator activity|metal ion binding AGAP2 187.76829516377 185.090051458156 190.446538869384 1.02893989908712 0.0411587161276751 0.887441559606348 1 0.87462 1.03515 0.869253 0.890212 GeneID:116986,Genbank:XM_017018772.2,HGNC:HGNC:16921,MIM:605476 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 hsa04068,hsa04144 FoxO signaling pathway|Endocytosis AGAP3 2252.44477538994 2330.49775930074 2174.39179147914 0.933016040372234 -0.100026210845107 0.462168336817472 1 16.9098 16.7937 15.5583 16.6641 GeneID:116988,Genbank:NM_001350104.1,HGNC:HGNC:16923,MIM:616813 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 GO:0003924,GO:0005096,GO:0005525,GO:0005737,GO:0007165,GO:0016020,GO:0046872 GTPase activity|GTPase activator activity|GTP binding|cytoplasm|signal transduction|membrane|metal ion binding hsa04144 Endocytosis AGAP4 75.9530848697532 78.7269739249019 73.1791958146045 0.929531419363464 -0.105424463961253 0.78068521295146 1 0.728872 0.758965 0.597707 0.685821 GeneID:119016,Genbank:NM_001291379.1,HGNC:HGNC:23459 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 GO:0005096,GO:0046872 GTPase activator activity|metal ion binding AGAP5 37.0360196021543 39.6565489381146 34.415490266194 0.867838760248667 -0.204501072261448 0.691815174233811 1 0.505932 0.475031 0.562599 0.350195 GeneID:729092,Genbank:NM_001144000.1,HGNC:HGNC:23467 ArfGAP with GTPase domain, ankyrin repeat and PH domain 5 GO:0005096,GO:0046872 GTPase activator activity|metal ion binding AGAP6 191.398416111335 196.688068970862 186.108763251808 0.946212773482358 -0.0797634581180358 0.732505506235063 1 1.54298 1.59288 1.58165 1.42829 GeneID:414189,Genbank:XM_017016272.1,HGNC:HGNC:23466 ArfGAP with GTPase domain, ankyrin repeat and PH domain 6 GO:0005096,GO:0046872 GTPase activator activity|metal ion binding AGAP9 56.9028187810735 62.43015614647 51.375481415677 0.822927325300017 -0.281163066499019 0.46489771572509 1 0.762512 0.807452 0.807567 0.628062 GeneID:642517,Genbank:NM_001190810.1,HGNC:HGNC:23463 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 AGBL1 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.00223742 0 0.00210692 GeneID:123624,Genbank:XM_011521227.3,HGNC:HGNC:26504,MIM:615496 ATP/GTP binding protein like 1 GO:0004181,GO:0005829,GO:0008270,GO:0015631,GO:0035609,GO:0035610 metallocarboxypeptidase activity|cytosol|zinc ion binding|tubulin binding|C-terminal protein deglutamylation|protein side chain deglutamylation AGBL2 8.78264166931362 7.38928864893743 10.1759946896898 1.37712778227348 0.461662431876025 0.648692700935573 1 0.0477063 0.0075402 0.0152257 0.0710408 GeneID:79841,Genbank:XM_011520373.3,HGNC:HGNC:26296,MIM:617345 ATP/GTP binding protein like 2 GO:0004181,GO:0005814,GO:0005829,GO:0008270,GO:0035610,GO:0036064 metallocarboxypeptidase activity|centriole|cytosol|zinc ion binding|protein side chain deglutamylation|ciliary basal body AGBL3 65.8082555345199 70.0693848239401 61.5471262450998 0.87837400599058 -0.187092734059021 0.60518381659718 1 0.23694 0.31633 0.262036 0.250463 GeneID:340351,Genbank:XM_017012137.2,HGNC:HGNC:27981,MIM:617346 ATP/GTP binding protein like 3 GO:0004181,GO:0005829,GO:0008270,GO:0035610 metallocarboxypeptidase activity|cytosol|zinc ion binding|protein side chain deglutamylation AGBL4 0.969266633120943 0 1.93853326624189 Inf Inf 0.451830900262006 1 0 0 0.00402302 0.00748583 GeneID:84871,Genbank:XM_017002595.2,HGNC:HGNC:25892,MIM:616476 ATP/GTP binding protein like 4 GO:0004181,GO:0005794,GO:0005814,GO:0005829,GO:0008270,GO:0015631,GO:0035608,GO:0035609,GO:0035610,GO:0036064,GO:0051607 metallocarboxypeptidase activity|Golgi apparatus|centriole|cytosol|zinc ion binding|tubulin binding|protein deglutamylation|C-terminal protein deglutamylation|protein side chain deglutamylation|ciliary basal body|defense response to virus AGBL5 1091.36004290334 967.825703576574 1214.89438223011 1.25528220395522 0.328011737465857 0.0308127157205772 0.695369080690778 8.36193 8.80004 10.9694 11.5382 GeneID:60509,Genbank:XM_011533011.3,HGNC:HGNC:26147,MIM:615900 ATP/GTP binding protein like 5 GO:0004181,GO:0005634,GO:0005737,GO:0005829,GO:0008270,GO:0015630,GO:0015631,GO:0030496,GO:0035608,GO:0035611,GO:0045171,GO:0051607,GO:0072686 metallocarboxypeptidase activity|nucleus|cytoplasm|cytosol|zinc ion binding|microtubule cytoskeleton|tubulin binding|midbody|protein deglutamylation|protein branching point deglutamylation|intercellular bridge|defense response to virus|mitotic spindle AGER 14.9769613301394 14.9324647770376 15.0214578832411 1.00595970642036 0.0085725193464872 1 1 0.0405435 0.163153 0.0566613 0.0706849 GeneID:177,Genbank:NM_001206932.1,HGNC:HGNC:320,MIM:600214 advanced glycosylation end-product specific receptor hsa04933 AGE-RAGE signaling pathway in diabetic complications AGFG1 968.240550568738 1003.98309211523 932.498009022245 0.928798518964718 -0.106562423161877 0.501711533894671 1 3.9124 3.71488 4.05301 3.20554 GeneID:3267,Genbank:XM_006712480.3,HGNC:HGNC:5175,MIM:600862 ArfGAP with FG repeats 1 GO:0001675,GO:0003677,GO:0003723,GO:0005096,GO:0005643,GO:0005829,GO:0006406,GO:0007275,GO:0007289,GO:0031410,GO:0042995,GO:0043025,GO:0043231,GO:0045109,GO:0046872,GO:0061024 acrosome assembly|DNA binding|RNA binding|GTPase activator activity|nuclear pore|cytosol|mRNA export from nucleus|multicellular organism development|spermatid nucleus differentiation|cytoplasmic vesicle|cell projection|neuronal cell body|intracellular membrane-bounded organelle|intermediate filament organization|metal ion binding|membrane organization hsa05164 Influenza A AGFG2 1488.59526800891 1591.97541156382 1385.215124454 0.870123441852208 -0.200708008506521 0.345530411590042 1 10.9242 12.8611 12.0361 8.95429 GeneID:3268,Genbank:NM_006076.4,HGNC:HGNC:5177,MIM:604019 ArfGAP with FG repeats 2 GO:0005096,GO:0016020,GO:0046872 GTPase activator activity|membrane|metal ion binding AGGF1 572.236734210821 579.34926265357 565.124205768073 0.975446491775372 -0.0358653590777437 0.851293247212417 1 4.66489 4.58538 5.01752 3.89139 GeneID:55109,Genbank:NM_018046.4,HGNC:HGNC:24684,MIM:608464 angiogenic factor with G-patch and FHA domains 1 GO:0001525,GO:0001570,GO:0001938,GO:0003676,GO:0005576,GO:0005737,GO:0007155,GO:0045766,GO:0048471 angiogenesis|vasculogenesis|positive regulation of endothelial cell proliferation|nucleic acid binding|extracellular region|cytoplasm|cell adhesion|positive regulation of angiogenesis|perinuclear region of cytoplasm AGK 1541.46077978194 1622.29590155026 1460.62565801363 0.900344787050171 -0.151450507543612 0.313786803983474 1 5.0002 4.34683 4.22351 4.3355 GeneID:55750,Genbank:NM_018238.3,HGNC:HGNC:21869,MIM:610345 acylglycerol kinase GO:0001729,GO:0003951,GO:0004143,GO:0005524,GO:0005739,GO:0005741,GO:0005743,GO:0005758,GO:0005829,GO:0031305,GO:0042721,GO:0043231,GO:0045039,GO:0046474,GO:0046513,GO:0047620 ceramide kinase activity|NAD+ kinase activity|diacylglycerol kinase activity|ATP binding|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|integral component of mitochondrial inner membrane|mitochondrial inner membrane protein insertion complex|intracellular membrane-bounded organelle|protein import into mitochondrial inner membrane|glycerophospholipid biosynthetic process|ceramide biosynthetic process|acylglycerol kinase activity hsa00561 Glycerolipid metabolism AGL 180.586087567327 172.136472598309 189.035702536346 1.09817344158941 0.135105926438009 0.637760121796492 1 0.812801 0.746124 1.07453 0.697574 GeneID:178,Genbank:XM_005270557.2,HGNC:HGNC:321,MIM:610860 amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase GO:0004133,GO:0004134,GO:0004135,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005978,GO:0005980,GO:0007584,GO:0016234,GO:0016529,GO:0030247,GO:0031593,GO:0034774,GO:0043033,GO:0043312,GO:0051384,GO:0102500,GO:1904813 glycogen debranching enzyme activity|4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|extracellular region|nucleus|cytoplasm|cytosol|glycogen biosynthetic process|glycogen catabolic process|response to nutrient|inclusion body|sarcoplasmic reticulum|polysaccharide binding|polyubiquitin modification-dependent protein binding|secretory granule lumen|isoamylase complex|neutrophil degranulation|response to glucocorticoid|beta-maltose 4-alpha-glucanotransferase activity|ficolin-1-rich granule lumen hsa00500 Starch and sucrose metabolism AGMAT 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:79814,Genbank:NM_024758.4,HGNC:HGNC:18407,MIM:617887 agmatinase GO:0005739,GO:0008295,GO:0008783,GO:0033388,GO:0046872,GO:0070062,GO:0097055 mitochondrion|spermidine biosynthetic process|agmatinase activity|putrescine biosynthetic process from arginine|metal ion binding|extracellular exosome|agmatine biosynthetic process hsa00330 Arginine and proline metabolism AGO1 1405.37935831922 1277.79263363532 1532.96608300312 1.19969863861387 0.262672049850772 0.066821304456938 0.912266462842959 4.36738 3.8169 5.30541 4.39595 GeneID:26523,Genbank:NM_001317123.1,HGNC:HGNC:3262,MIM:606228 argonaute 1, RISC catalytic component GO:0000932,GO:0000956,GO:0000978,GO:0000993,GO:0001047,GO:0003723,GO:0003725,GO:0003727,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0006351,GO:0007223,GO:0010501,GO:0010586,GO:0016442,GO:0016525,GO:0030529,GO:0031054,GO:0035068,GO:0035194,GO:0035196,GO:0035198,GO:0035278,GO:0035280,GO:0045652,GO:0045944,GO:0060964,GO:0070578,GO:1901224 P-body|nuclear-transcribed mRNA catabolic process|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II core binding|core promoter binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|polysome|transcription, DNA-templated|Wnt signaling pathway, calcium modulating pathway|RNA secondary structure unwinding|miRNA metabolic process|RISC complex|negative regulation of angiogenesis|intracellular ribonucleoprotein complex|pre-miRNA processing|micro-ribonucleoprotein complex|posttranscriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|miRNA binding|miRNA mediated inhibition of translation|miRNA loading onto RISC involved in gene silencing by miRNA|regulation of megakaryocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of gene silencing by miRNA|RISC-loading complex|positive regulation of NIK/NF-kappaB signaling AGO2 1302.4290629268 1391.68130398817 1213.17682186543 0.871734655332945 -0.19803903063147 0.257624245383826 1 3.45962 3.57803 3.60626 2.56878 GeneID:27161,Genbank:NM_001164623.2,HGNC:HGNC:3263,MIM:606229 argonaute 2, RISC catalytic component GO:0000340,GO:0000932,GO:0000993,GO:0001047,GO:0003723,GO:0003725,GO:0003727,GO:0003743,GO:0004521,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0005845,GO:0006351,GO:0006412,GO:0007223,GO:0008022,GO:0009791,GO:0010501,GO:0010586,GO:0016020,GO:0016442,GO:0030054,GO:0030422,GO:0030425,GO:0030529,GO:0031047,GO:0031054,GO:0035068,GO:0035087,GO:0035194,GO:0035196,GO:0035197,GO:0035198,GO:0035278,GO:0035279,GO:0035280,GO:0045944,GO:0045947,GO:0046872,GO:0060213,GO:0060964,GO:0070062,GO:0070551,GO:0070578,GO:0090624,GO:0090625,GO:0098808,GO:1900153,GO:1905618 RNA 7-methylguanosine cap binding|P-body|RNA polymerase II core binding|core promoter binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|translation initiation factor activity|endoribonuclease activity|nucleus|nucleoplasm|cytoplasm|cytosol|polysome|mRNA cap binding complex|transcription, DNA-templated|translation|Wnt signaling pathway, calcium modulating pathway|protein C-terminus binding|post-embryonic development|RNA secondary structure unwinding|miRNA metabolic process|membrane|RISC complex|cell junction|production of siRNA involved in RNA interference|dendrite|intracellular ribonucleoprotein complex|gene silencing by RNA|pre-miRNA processing|micro-ribonucleoprotein complex|siRNA loading onto RISC involved in RNA interference|posttranscriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|siRNA binding|miRNA binding|miRNA mediated inhibition of translation|mRNA cleavage involved in gene silencing by miRNA|miRNA loading onto RISC involved in gene silencing by miRNA|positive regulation of transcription from RNA polymerase II promoter|negative regulation of translational initiation|metal ion binding|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of gene silencing by miRNA|extracellular exosome|endoribonuclease activity, cleaving siRNA-paired mRNA|RISC-loading complex|endoribonuclease activity, cleaving miRNA-paired mRNA|mRNA cleavage involved in gene silencing by siRNA|mRNA cap binding|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|positive regulation of miRNA mediated inhibition of translation AGO3 275.790525517852 269.986039854656 281.595011181049 1.04299841329812 0.0607369631034366 0.7826031955123 1 0.821019 0.901959 1.02143 0.800352 GeneID:192669,Genbank:XM_017000523.2,HGNC:HGNC:18421,MIM:607355 argonaute 3, RISC catalytic component GO:0000794,GO:0000932,GO:0003723,GO:0003725,GO:0003727,GO:0005654,GO:0005737,GO:0005829,GO:0006402,GO:0007223,GO:0010501,GO:0010628,GO:0016020,GO:0016442,GO:0031054,GO:0035068,GO:0035194,GO:0035196,GO:0035198,GO:0035278,GO:0035280,GO:0036464,GO:0045652,GO:0070578,GO:0072091,GO:1901224 condensed nuclear chromosome|P-body|RNA binding|double-stranded RNA binding|single-stranded RNA binding|nucleoplasm|cytoplasm|cytosol|mRNA catabolic process|Wnt signaling pathway, calcium modulating pathway|RNA secondary structure unwinding|positive regulation of gene expression|membrane|RISC complex|pre-miRNA processing|micro-ribonucleoprotein complex|posttranscriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|miRNA binding|miRNA mediated inhibition of translation|miRNA loading onto RISC involved in gene silencing by miRNA|cytoplasmic ribonucleoprotein granule|regulation of megakaryocyte differentiation|RISC-loading complex|regulation of stem cell proliferation|positive regulation of NIK/NF-kappaB signaling AGO4 322.359441305971 309.815076581294 334.903806030647 1.08097969190589 0.112339419777586 0.554567341255809 1 1.59189 1.48186 1.93449 1.57589 GeneID:192670,Genbank:XM_005270578.3,HGNC:HGNC:18424,MIM:607356 argonaute 4, RISC catalytic component GO:0000932,GO:0003725,GO:0003727,GO:0005654,GO:0005737,GO:0005829,GO:0006402,GO:0007130,GO:0007140,GO:0007223,GO:0008584,GO:0010501,GO:0010586,GO:0016020,GO:0016442,GO:0016604,GO:0022604,GO:0031054,GO:0035068,GO:0035194,GO:0035196,GO:0035198,GO:0035278,GO:0035280,GO:0043066,GO:0045652,GO:0070578 P-body|double-stranded RNA binding|single-stranded RNA binding|nucleoplasm|cytoplasm|cytosol|mRNA catabolic process|synaptonemal complex assembly|male meiotic nuclear division|Wnt signaling pathway, calcium modulating pathway|male gonad development|RNA secondary structure unwinding|miRNA metabolic process|membrane|RISC complex|nuclear body|regulation of cell morphogenesis|pre-miRNA processing|micro-ribonucleoprotein complex|posttranscriptional gene silencing by RNA|production of miRNAs involved in gene silencing by miRNA|miRNA binding|miRNA mediated inhibition of translation|miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of apoptotic process|regulation of megakaryocyte differentiation|RISC-loading complex AGPAT1 3168.80994981941 3116.87563364182 3220.74426599699 1.03332459955542 0.047293521006104 0.744326202004088 1 28.1677 30.3898 30.4053 31.0341 GeneID:10554,Genbank:NM_032741.4,HGNC:HGNC:324,MIM:603099 1-acylglycerol-3-phosphate O-acyltransferase 1 GO:0001819,GO:0001961,GO:0003841,GO:0005783,GO:0005789,GO:0006644,GO:0006654,GO:0016020,GO:0016021,GO:0016024,GO:0031325 positive regulation of cytokine production|positive regulation of cytokine-mediated signaling pathway|1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|phospholipid metabolic process|phosphatidic acid biosynthetic process|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|positive regulation of cellular metabolic process hsa00561,hsa00564,hsa04072,hsa04975 Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway|Fat digestion and absorption AGPAT2 586.702992470415 616.604497857437 556.801487083392 0.903012366951835 -0.147182349021861 0.375905969302977 1 17.8626 18.2316 16.0966 17.5198 GeneID:10555,Genbank:NM_001012727.1,HGNC:HGNC:325,MIM:603100 1-acylglycerol-3-phosphate O-acyltransferase 2 GO:0001819,GO:0001961,GO:0003841,GO:0005783,GO:0005789,GO:0005886,GO:0006644,GO:0006654,GO:0008544,GO:0016021,GO:0016024,GO:0035579,GO:0042493,GO:0043312 positive regulation of cytokine production|positive regulation of cytokine-mediated signaling pathway|1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|phospholipid metabolic process|phosphatidic acid biosynthetic process|epidermis development|integral component of membrane|CDP-diacylglycerol biosynthetic process|specific granule membrane|response to drug|neutrophil degranulation hsa00561,hsa00564,hsa04072,hsa04975 Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway|Fat digestion and absorption AGPAT3 2105.11091717005 2165.15362574408 2045.06820859601 0.944537230189934 -0.0823204314110233 0.552303821382849 1 9.35848 9.43649 8.89864 9.07297 GeneID:56894,Genbank:XM_006724031.3,HGNC:HGNC:326,MIM:614794 1-acylglycerol-3-phosphate O-acyltransferase 3 GO:0000139,GO:0003841,GO:0005635,GO:0005783,GO:0005789,GO:0005886,GO:0006654,GO:0008654,GO:0016020,GO:0016021,GO:0016024 Golgi membrane|1-acylglycerol-3-phosphate O-acyltransferase activity|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process hsa00561,hsa00564,hsa04072 Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway AGPAT4 555.739698175915 548.303293542587 563.176102809244 1.02712515033525 0.038611977924635 0.839409024949848 1 2.35674 2.4764 2.70803 2.28482 GeneID:56895,Genbank:XM_017011059.1,HGNC:HGNC:20885,MIM:614795 1-acylglycerol-3-phosphate O-acyltransferase 4 GO:0003841,GO:0005789,GO:0006654,GO:0008654,GO:0016021,GO:0016024 1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum membrane|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|integral component of membrane|CDP-diacylglycerol biosynthetic process hsa00561,hsa00564,hsa04072 Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway AGPAT5 1710.80772024536 1991.04400788027 1430.57143261045 0.718503170672498 -0.476933571742126 0.000941896181692819 0.099246113460475 18.8197 17.6423 12.938 13.2563 GeneID:55326,Genbank:NM_018361.3,HGNC:HGNC:20886,MIM:614796 1-acylglycerol-3-phosphate O-acyltransferase 5 GO:0002244,GO:0003841,GO:0005635,GO:0005739,GO:0005741,GO:0005789,GO:0006639,GO:0006654,GO:0008654,GO:0016021,GO:0016024 hematopoietic progenitor cell differentiation|1-acylglycerol-3-phosphate O-acyltransferase activity|nuclear envelope|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum membrane|acylglycerol metabolic process|phosphatidic acid biosynthetic process|phospholipid biosynthetic process|integral component of membrane|CDP-diacylglycerol biosynthetic process hsa00561,hsa00564,hsa04072 Glycerolipid metabolism|Glycerophospholipid metabolism|Phospholipase D signaling pathway AGPS 1798.51890159079 1900.69939913245 1696.33840404913 0.892481159736989 -0.164106380693419 0.305247968545752 1 9.18445 8.55334 9.09638 7.00151 GeneID:8540,Genbank:NM_003659.3,HGNC:HGNC:327,MIM:603051 alkylglycerone phosphate synthase GO:0005730,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0008609,GO:0008610,GO:0008611,GO:0016020,GO:0016614,GO:0071949 nucleolus|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|alkylglycerone-phosphate synthase activity|lipid biosynthetic process|ether lipid biosynthetic process|membrane|oxidoreductase activity, acting on CH-OH group of donors|FAD binding hsa00565,hsa04146 Ether lipid metabolism|Peroxisome AGRN 6588.35233098572 6401.30867747923 6775.39598449222 1.05843919202476 0.0819383880188432 0.707506341842782 1 41.0163 42.528 52.5062 39.3234 GeneID:375790,Genbank:XM_005244749.3,HGNC:HGNC:329,MIM:103320 agrin hsa04512 ECM-receptor interaction AGRP 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0743198 GeneID:181,Genbank:NM_001138.1,HGNC:HGNC:330,MIM:602311 agouti related neuropeptide hsa04920 Adipocytokine signaling pathway AGT 11.9929888914323 13.8082431490681 10.1777346337966 0.737076724672501 -0.440113293011689 0.623142087298831 1 0.223546 0.229625 0.191383 0.146006 GeneID:183,Genbank:NM_000029.3,HGNC:HGNC:333,MIM:106150 angiotensinogen hsa04270,hsa04614,hsa04924,hsa05410 Vascular smooth muscle contraction|Renin-angiotensin system|Renin secretion|Hypertrophic cardiomyopathy (HCM) AGTPBP1 136.013131766759 135.352708487038 136.67355504648 1.00975855285208 0.0140103660014057 0.943008936223457 1 0.403342 0.196253 0.380639 0.306997 GeneID:23287,Genbank:NM_001286717.1,HGNC:HGNC:17258,MIM:606830 ATP/GTP binding protein 1 GO:0001754,GO:0004181,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0007005,GO:0008270,GO:0015631,GO:0021702,GO:0021772,GO:0035609,GO:0035610,GO:0043231,GO:0050905 eye photoreceptor cell differentiation|metallocarboxypeptidase activity|nucleus|nucleolus|cytoplasm|mitochondrion|cytosol|mitochondrion organization|zinc ion binding|tubulin binding|cerebellar Purkinje cell differentiation|olfactory bulb development|C-terminal protein deglutamylation|protein side chain deglutamylation|intracellular membrane-bounded organelle|neuromuscular process AGTR1 9.14601270755674 6.65908587355536 11.6329395415581 1.74692739550859 0.804819649287091 0.426771956855882 1 0.120605 0.11313 0.211493 0.1072 GeneID:185,Genbank:NM_031850.3,HGNC:HGNC:336,MIM:106165 angiotensin II receptor type 1 hsa04020,hsa04022,hsa04072,hsa04080,hsa04261,hsa04270,hsa04371,hsa04614,hsa04924,hsa04925,hsa04927,hsa04933,hsa04934,hsa05200 Calcium signaling pathway|cGMP-PKG signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Renin-angiotensin system|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Pathways in cancer AGTRAP 452.685864729324 443.987762512279 461.38396694637 1.03918172054035 0.055447958764358 0.794602695995788 1 12.93 14.5578 16.0884 13.753 GeneID:57085,Genbank:NM_001040197.1,HGNC:HGNC:13539,MIM:608729 angiotensin II receptor associated protein AHCTF1 381.700395715275 408.5761260558 354.82466537475 0.868441993417626 -0.203498605886658 0.645703461631483 1 1.77473 1.30538 1.69399 0.991183 GeneID:25909,Genbank:NM_001323343.1,HGNC:HGNC:24618,MIM:610853 AT-hook containing transcription factor 1 GO:0000777,GO:0000910,GO:0003677,GO:0003700,GO:0005634,GO:0005643,GO:0005654,GO:0005829,GO:0007062,GO:0015031,GO:0016363,GO:0031965,GO:0034399,GO:0051028,GO:0051292,GO:0070062 condensed chromosome kinetochore|cytokinesis|DNA binding|DNA binding transcription factor activity|nucleus|nuclear pore|nucleoplasm|cytosol|sister chromatid cohesion|protein transport|nuclear matrix|nuclear membrane|nuclear periphery|mRNA transport|nuclear pore complex assembly|extracellular exosome AHCY 5040.64185130061 5070.89778003911 5010.38592256211 0.988066835479273 -0.0173194620315924 0.888863314867958 1 33.3369 33.4069 33.1036 34.1556 GeneID:191,Genbank:XM_011528657.2,HGNC:HGNC:343,MIM:180960 adenosylhomocysteinase GO:0000096,GO:0001666,GO:0002439,GO:0004013,GO:0005634,GO:0005829,GO:0006730,GO:0007584,GO:0019510,GO:0030554,GO:0032259,GO:0033353,GO:0042470,GO:0042745,GO:0042802,GO:0043005,GO:0051287,GO:0070062,GO:0071268 sulfur amino acid metabolic process|response to hypoxia|chronic inflammatory response to antigenic stimulus|adenosylhomocysteinase activity|nucleus|cytosol|one-carbon metabolic process|response to nutrient|S-adenosylhomocysteine catabolic process|adenyl nucleotide binding|methylation|S-adenosylmethionine cycle|melanosome|circadian sleep/wake cycle|identical protein binding|neuron projection|NAD binding|extracellular exosome|homocysteine biosynthetic process hsa00270 Cysteine and methionine metabolism AHCYL1 3834.77032501974 3716.47846890735 3953.06218113213 1.06365803386299 0.0890343988203014 0.506032332115965 1 27.9273 27.7648 30.6067 30.0541 GeneID:10768,Genbank:NM_001242673.1,HGNC:HGNC:344,MIM:607826 adenosylhomocysteinase like 1 GO:0003723,GO:0005737,GO:0005783,GO:0005829,GO:0006378,GO:0006611,GO:0006730,GO:0010765,GO:0016324,GO:0031440,GO:0032412,GO:0033353,GO:0038166,GO:0042045,GO:0042802,GO:0043231,GO:0044070,GO:0051592 RNA binding|cytoplasm|endoplasmic reticulum|cytosol|mRNA polyadenylation|protein export from nucleus|one-carbon metabolic process|positive regulation of sodium ion transport|apical plasma membrane|regulation of mRNA 3'-end processing|regulation of ion transmembrane transporter activity|S-adenosylmethionine cycle|angiotensin-activated signaling pathway|epithelial fluid transport|identical protein binding|intracellular membrane-bounded organelle|regulation of anion transport|response to calcium ion hsa00270 Cysteine and methionine metabolism AHCYL2 975.464129352646 919.146972650234 1031.78128605506 1.12254222312244 0.166769711285993 0.294519072312601 1 4.43677 5.44084 5.80137 5.48864 GeneID:23382,Genbank:NM_015328.3,HGNC:HGNC:22204,MIM:616520 adenosylhomocysteinase like 2 GO:0005783,GO:0005829,GO:0006730,GO:0016787,GO:0033353,GO:0043005 endoplasmic reticulum|cytosol|one-carbon metabolic process|hydrolase activity|S-adenosylmethionine cycle|neuron projection hsa00270 Cysteine and methionine metabolism AHDC1 480.718302991 539.837809540365 421.598796441634 0.780973079304314 -0.356655276383806 0.0406961375897891 0.759435523043776 2.53551 2.60132 1.94164 2.16472 GeneID:27245,Genbank:NM_001029882.3,HGNC:HGNC:25230,MIM:615790 AT-hook DNA binding motif containing 1 GO:0003677 DNA binding AHI1 138.546690115004 153.48535035946 123.608029870549 0.805340897884137 -0.312328494789112 0.375953019077841 1 0.616545 0.540871 0.547326 0.331707 GeneID:54806,Genbank:NM_001134830.1,HGNC:HGNC:21575,MIM:608894 Abelson helper integration site 1 GO:0001738,GO:0001947,GO:0002092,GO:0005813,GO:0005814,GO:0005829,GO:0005911,GO:0005912,GO:0005929,GO:0007169,GO:0007417,GO:0010842,GO:0016192,GO:0030862,GO:0030902,GO:0034613,GO:0035844,GO:0035845,GO:0036038,GO:0036064,GO:0039008,GO:0039023,GO:0042802,GO:0043066,GO:0045944,GO:0050795,GO:0060271,GO:0065001,GO:0070121,GO:0070986,GO:0071599,GO:0097711,GO:0097730 morphogenesis of a polarized epithelium|heart looping|positive regulation of receptor internalization|centrosome|centriole|cytosol|cell-cell junction|adherens junction|cilium|transmembrane receptor protein tyrosine kinase signaling pathway|central nervous system development|retina layer formation|vesicle-mediated transport|positive regulation of polarized epithelial cell differentiation|hindbrain development|cellular protein localization|cloaca development|photoreceptor cell outer segment organization|MKS complex|ciliary basal body|pronephric nephron tubule morphogenesis|pronephric duct morphogenesis|identical protein binding|negative regulation of apoptotic process|positive regulation of transcription from RNA polymerase II promoter|regulation of behavior|cilium assembly|specification of axis polarity|Kupffer's vesicle development|left/right axis specification|otic vesicle development|ciliary basal body-plasma membrane docking|non-motile cilium AHNAK 10044.2925271794 9646.79031148597 10441.7947428728 1.08241128973647 0.114248792063706 0.760046730489156 1 11.2498 11.4232 15.9786 9.02661 GeneID:79026,Genbank:NM_024060.3,HGNC:HGNC:347,MIM:103390 AHNAK nucleoprotein GO:0003723,GO:0005634,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0005925,GO:0015629,GO:0016020,GO:0030315,GO:0031982,GO:0042383,GO:0043034,GO:0043484,GO:0044291,GO:0044548,GO:0045296,GO:0051259,GO:0070062,GO:0097493,GO:1901385 RNA binding|nucleus|cytoplasm|lysosomal membrane|cytosol|plasma membrane|focal adhesion|actin cytoskeleton|membrane|T-tubule|vesicle|sarcolemma|costamere|regulation of RNA splicing|cell-cell contact zone|S100 protein binding|cadherin binding|protein oligomerization|extracellular exosome|structural molecule activity conferring elasticity|regulation of voltage-gated calcium channel activity AHNAK2 2288.7625226133 1902.70197036327 2674.82307486333 1.40580244122659 0.491393865328935 0.000448839155806091 0.0589230157327078 2.74347 2.88839 4.39428 3.6579 GeneID:113146,Genbank:NM_138420.3,HGNC:HGNC:20125,MIM:608570 AHNAK nucleoprotein 2 GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0030018,GO:0030315,GO:0030659,GO:0042383,GO:0043034 nucleus|cytoplasm|cytosol|plasma membrane|Z disc|T-tubule|cytoplasmic vesicle membrane|sarcolemma|costamere AHRR 47.6981933204148 44.0191652810459 51.3772213597838 1.16715573845527 0.222997078702697 0.612177215516448 1 0.266619 0.323578 0.419227 0.334247 GeneID:57491,Genbank:NM_020731.4,HGNC:HGNC:346,MIM:606517 aryl-hydrocarbon receptor repressor GO:0001191,GO:0003677,GO:0005654,GO:0005829,GO:0006351,GO:0006805,GO:0009410,GO:0046983 transcriptional repressor activity, RNA polymerase II transcription factor binding|DNA binding|nucleoplasm|cytosol|transcription, DNA-templated|xenobiotic metabolic process|response to xenobiotic stimulus|protein dimerization activity AHSA1 2863.04328821602 2850.91500920645 2875.17156722559 1.00850834133631 0.0122230164791471 0.940970078944434 1 59.2579 63.3126 61.7214 63.9215 GeneID:10598,Genbank:NM_001321441.1,HGNC:HGNC:1189,MIM:608466 activator of HSP90 ATPase activity 1 GO:0001671,GO:0005783,GO:0005829,GO:0006950,GO:0045296,GO:0051087,GO:0070062 ATPase activator activity|endoplasmic reticulum|cytosol|response to stress|cadherin binding|chaperone binding|extracellular exosome AIDA 641.36867575976 648.256208229963 634.481143289558 0.978750585392745 -0.0309868296045444 0.904508132778464 1 8.17958 8.60719 10.2699 6.70302 GeneID:64853,Genbank:NM_022831.2,HGNC:HGNC:25761,MIM:612375 axin interactor, dorsalization associated GO:0005737,GO:0009953,GO:0016020,GO:0019904,GO:0035091,GO:0043496,GO:0043508,GO:0046329,GO:0048264 cytoplasm|dorsal/ventral pattern formation|membrane|protein domain specific binding|phosphatidylinositol binding|regulation of protein homodimerization activity|negative regulation of JUN kinase activity|negative regulation of JNK cascade|determination of ventral identity AIF1L 2936.6488548496 2611.00460431397 3262.29310538523 1.24943981331752 0.321281407131163 0.0233812492555036 0.616997337836357 23.9216 24.4523 28.5914 32.3717 GeneID:83543,Genbank:NM_001185095.1,HGNC:HGNC:28904 allograft inflammatory factor 1 like GO:0005509,GO:0005737,GO:0005925,GO:0015629,GO:0032587,GO:0043234,GO:0051015,GO:0070062 calcium ion binding|cytoplasm|focal adhesion|actin cytoskeleton|ruffle membrane|protein complex|actin filament binding|extracellular exosome AIFM1 3537.41902524562 3558.40221348835 3516.43583700288 0.988206398836424 -0.017115697329333 0.887734303685822 1 30.1465 31.6698 31.8624 30.8745 GeneID:9131,Genbank:NM_145812.2,HGNC:HGNC:8768,MIM:310490 apoptosis inducing factor mitochondria associated 1 hsa04210,hsa04217 Apoptosis|Necroptosis AIFM2 2101.75996956375 2066.81297008492 2136.70696904258 1.0338172829227 0.0479812259674092 0.724784659620676 1 25.3273 24.6222 26.7485 26.0197 GeneID:84883,Genbank:NM_032797.5,HGNC:HGNC:21411,MIM:605159 apoptosis inducing factor, mitochondria associated 2 hsa04115 p53 signaling pathway AIFM3 0.968396661067546 0 1.93679332213509 Inf Inf 0.496080204589898 1 0 0 0 0.0702984 GeneID:150209,Genbank:NM_144704.2,HGNC:HGNC:26398,MIM:617298 apoptosis inducing factor, mitochondria associated 3 GO:0005739,GO:0005743,GO:0005783,GO:0005829,GO:0016491,GO:0046872,GO:0050660,GO:0051537,GO:0097194 mitochondrion|mitochondrial inner membrane|endoplasmic reticulum|cytosol|oxidoreductase activity|metal ion binding|flavin adenine dinucleotide binding|2 iron, 2 sulfur cluster binding|execution phase of apoptosis AIG1 882.190627314025 876.57738726399 887.80386736406 1.01280717511447 0.0183595305200747 0.910313357300498 1 3.08129 2.93362 2.95363 2.9644 GeneID:51390,Genbank:NM_001286587.1,HGNC:HGNC:21607,MIM:608514 androgen induced 1 GO:0012505,GO:0016020,GO:0016021,GO:0016787,GO:0042758 endomembrane system|membrane|integral component of membrane|hydrolase activity|long-chain fatty acid catabolic process AIMP1 642.849294985759 651.819961211757 633.878628759762 0.972475018379859 -0.0402669052743004 0.856999321869987 1 4.45649 3.74588 3.93288 3.90037 GeneID:9255,Genbank:NM_001142415.1,HGNC:HGNC:10648,MIM:603605 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 GO:0000049,GO:0001525,GO:0001937,GO:0005125,GO:0005615,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0006006,GO:0006418,GO:0006915,GO:0006935,GO:0006954,GO:0007155,GO:0007165,GO:0007267,GO:0009611,GO:0009986,GO:0016020,GO:0017101,GO:0017102,GO:0030133,GO:0042803,GO:0050900,GO:0051020,GO:0051607 tRNA binding|angiogenesis|negative regulation of endothelial cell proliferation|cytokine activity|extracellular space|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|glucose metabolic process|tRNA aminoacylation for protein translation|apoptotic process|chemotaxis|inflammatory response|cell adhesion|signal transduction|cell-cell signaling|response to wounding|cell surface|membrane|aminoacyl-tRNA synthetase multienzyme complex|methionyl glutamyl tRNA synthetase complex|transport vesicle|protein homodimerization activity|leukocyte migration|GTPase binding|defense response to virus AIMP2 1734.75979757771 1890.19922828495 1579.32036687046 0.835531166893681 -0.259234450341993 0.0689249188159478 0.918407228165493 28.1142 26.7288 21.8753 24.3898 GeneID:7965,Genbank:NM_001326609.1,HGNC:HGNC:20609,MIM:600859 aminoacyl tRNA synthetase complex interacting multifunctional protein 2 GO:0005634,GO:0005829,GO:0006418,GO:0006461,GO:0006915,GO:0008285,GO:0016020,GO:0017101,GO:0031398,GO:0032947,GO:0060510,GO:1901216,GO:1903632 nucleus|cytosol|tRNA aminoacylation for protein translation|protein complex assembly|apoptotic process|negative regulation of cell proliferation|membrane|aminoacyl-tRNA synthetase multienzyme complex|positive regulation of protein ubiquitination|protein complex scaffold activity|Type II pneumocyte differentiation|positive regulation of neuron death|positive regulation of aminoacyl-tRNA ligase activity AIP 1178.36665513286 1217.02886479688 1139.70444546883 0.936464597048849 -0.0947036403309495 0.696646780041919 1 17.7881 21.8446 16.2256 21.1959 GeneID:9049,Genbank:XM_024448761.1,HGNC:HGNC:358,MIM:605555 aryl hydrocarbon receptor interacting protein hsa04934 Cushing syndrome AJAP1 36.3773618247444 24.7721104357619 47.982613213727 1.9369610569981 0.95379494855113 0.0426613243437384 0.77030864790227 0.0753425 0.0566059 0.149276 0.112155 GeneID:55966,Genbank:XM_011541786.2,HGNC:HGNC:30801,MIM:610972 adherens junctions associated protein 1 GO:0001953,GO:0005913,GO:0007155,GO:0008013,GO:0009898,GO:0009986,GO:0016323,GO:0016324,GO:0030860,GO:0032403,GO:0044214,GO:0044291,GO:0061045 negative regulation of cell-matrix adhesion|cell-cell adherens junction|cell adhesion|beta-catenin binding|cytoplasmic side of plasma membrane|cell surface|basolateral plasma membrane|apical plasma membrane|regulation of polarized epithelial cell differentiation|protein complex binding|spanning component of plasma membrane|cell-cell contact zone|negative regulation of wound healing AJM1 75.0249624573133 60.3836266443786 89.6662982702479 1.48494390372287 0.57040843180083 0.107493454789118 1 0.912137 1.40948 2.41142 1.7098 GeneID:389813,Genbank:NM_001080482.3,HGNC:HGNC:37284 apical junction component 1 homolog GO:0005912,GO:0005929,GO:0016324 adherens junction|cilium|apical plasma membrane AJUBA 1745.60855990699 1871.66479290654 1619.55232690744 0.86530041759903 -0.208726995970202 0.13736511515722 1 15.5835 16.7158 13.9743 14.5012 GeneID:84962,Genbank:NM_032876.5,HGNC:HGNC:20250,MIM:609066 ajuba LIM protein GO:0000086,GO:0000122,GO:0000932,GO:0001666,GO:0003682,GO:0003714,GO:0005634,GO:0005667,GO:0005794,GO:0005815,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0005925,GO:0006351,GO:0006355,GO:0007010,GO:0016339,GO:0030027,GO:0030032,GO:0030334,GO:0031328,GO:0031334,GO:0033673,GO:0034613,GO:0035195,GO:0035313,GO:0035331,GO:0043087,GO:0043123,GO:0043406,GO:0045294,GO:0046474,GO:0046872,GO:0048041,GO:0051015,GO:1900037,GO:2000637 G2/M transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|P-body|response to hypoxia|chromatin binding|transcription corepressor activity|nucleus|transcription factor complex|Golgi apparatus|microtubule organizing center|cytosol|plasma membrane|cell-cell junction|adherens junction|focal adhesion|transcription, DNA-templated|regulation of transcription, DNA-templated|cytoskeleton organization|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|lamellipodium|lamellipodium assembly|regulation of cell migration|positive regulation of cellular biosynthetic process|positive regulation of protein complex assembly|negative regulation of kinase activity|cellular protein localization|gene silencing by miRNA|wound healing, spreading of epidermal cells|negative regulation of hippo signaling|regulation of GTPase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|alpha-catenin binding|glycerophospholipid biosynthetic process|metal ion binding|focal adhesion assembly|actin filament binding|regulation of cellular response to hypoxia|positive regulation of gene silencing by miRNA hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species AK1 713.068239402417 687.173762738442 738.962716066391 1.07536514945152 0.104826622468841 0.680656745891263 1 7.10752 7.76169 7.12717 9.08782 GeneID:203,Genbank:NM_001318121.1,HGNC:HGNC:361,MIM:103000 adenylate kinase 1 hsa00230,hsa00730 Purine metabolism|Thiamine metabolism AK2 5298.17469313073 5613.70544395654 4982.64394230493 0.887585569290782 -0.172041883055307 0.189208314164475 1 28.1858 30.2078 25.3711 26.9589 GeneID:204,Genbank:NM_001319142.1,HGNC:HGNC:362,MIM:103020 adenylate kinase 2 GO:0004017,GO:0005524,GO:0005743,GO:0005758,GO:0006172,GO:0015949,GO:0070062,GO:0097226 adenylate kinase activity|ATP binding|mitochondrial inner membrane|mitochondrial intermembrane space|ADP biosynthetic process|nucleobase-containing small molecule interconversion|extracellular exosome|sperm mitochondrial sheath hsa00230,hsa00730 Purine metabolism|Thiamine metabolism AK3 1979.16905685352 2019.70828056722 1938.62983313981 0.959856357372243 -0.0591095723995445 0.693731632465686 1 19.5405 18.342 20.3044 16.6685 GeneID:50808,Genbank:NM_001199853.1,HGNC:HGNC:17376,MIM:609290 adenylate kinase 3 GO:0005524,GO:0005525,GO:0005739,GO:0005759,GO:0007596,GO:0046033,GO:0046039,GO:0046041,GO:0046051,GO:0046899 ATP binding|GTP binding|mitochondrion|mitochondrial matrix|blood coagulation|AMP metabolic process|GTP metabolic process|ITP metabolic process|UTP metabolic process|nucleoside triphosphate adenylate kinase activity hsa00230 Purine metabolism AK4 656.92505921402 677.06455974097 636.785558687071 0.940509364322203 -0.0884857866583537 0.58825492074073 1 4.02418 4.23097 3.89421 3.83785 GeneID:205,Genbank:XM_017000613.1,HGNC:HGNC:363,MIM:103030 adenylate kinase 4 GO:0001889,GO:0004017,GO:0004550,GO:0005524,GO:0005525,GO:0005739,GO:0005759,GO:0006165,GO:0007420,GO:0009142,GO:0015949,GO:0042493,GO:0046033,GO:0046034,GO:0046039,GO:0046899,GO:0050145,GO:0070062 liver development|adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|GTP binding|mitochondrion|mitochondrial matrix|nucleoside diphosphate phosphorylation|brain development|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|response to drug|AMP metabolic process|ATP metabolic process|GTP metabolic process|nucleoside triphosphate adenylate kinase activity|nucleoside phosphate kinase activity|extracellular exosome hsa00230,hsa00730 Purine metabolism|Thiamine metabolism AK5 44.0272259190781 37.6482370556002 50.406214782556 1.33887317772979 0.421019310531099 0.325928718347146 1 0.186086 0.139685 0.23702 0.187526 GeneID:26289,Genbank:XM_017001012.1,HGNC:HGNC:365,MIM:608009 adenylate kinase 5 GO:0004017,GO:0004550,GO:0005524,GO:0005815,GO:0005829,GO:0006165,GO:0006172,GO:0006173,GO:0009142,GO:0009220,GO:0015949,GO:0019206,GO:0046034 adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|microtubule organizing center|cytosol|nucleoside diphosphate phosphorylation|ADP biosynthetic process|dADP biosynthetic process|nucleoside triphosphate biosynthetic process|pyrimidine ribonucleotide biosynthetic process|nucleobase-containing small molecule interconversion|nucleoside kinase activity|ATP metabolic process hsa00230,hsa00730 Purine metabolism|Thiamine metabolism AK6 394.669338179221 420.050699055522 369.287977302919 0.87915096471273 -0.185817173726021 0.316307106734427 1 19.0222 18.3232 17.3192 15.5771 GeneID:102157402,Genbank:NM_001015891.1,HGNC:HGNC:49151 adenylate kinase 6 GO:0004017,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0015030,GO:0015949,GO:0016020,GO:0050145 adenylate kinase activity|ATP binding|nucleoplasm|cytoplasm|cytosol|Cajal body|nucleobase-containing small molecule interconversion|membrane|nucleoside phosphate kinase activity hsa00230,hsa03008 Purine metabolism|Ribosome biogenesis in eukaryotes AK7 1.02273099320278 1.07619535328461 0.969266633120943 0.900641904987498 -0.150974490057726 1 1 0.0212092 0 0.0102133 0.00946509 GeneID:122481,Genbank:NM_152327.4,HGNC:HGNC:20091,MIM:615364 adenylate kinase 7 GO:0004017,GO:0004127,GO:0004550,GO:0005524,GO:0005829,GO:0006165,GO:0009142,GO:0015949,GO:0019206,GO:0030030 adenylate kinase activity|cytidylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|cytosol|nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|nucleoside kinase activity|cell projection organization hsa00230,hsa00730 Purine metabolism|Thiamine metabolism AK8 2.24497296238439 3.03648096111406 1.45346496365472 0.478667570213071 -1.06290402828578 0.698606856036559 1 0.00706767 0.0127493 0 0 GeneID:158067,Genbank:XM_005272169.2,HGNC:HGNC:26526,MIM:615365 adenylate kinase 8 GO:0004017,GO:0004127,GO:0004550,GO:0005524,GO:0005829,GO:0005930,GO:0006165,GO:0009142,GO:0015949,GO:0019206,GO:0021591,GO:0036126 adenylate kinase activity|cytidylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|cytosol|axoneme|nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|nucleoside kinase activity|ventricular system development|sperm flagellum hsa00230,hsa00730 Purine metabolism|Thiamine metabolism AK9 52.1629199215772 51.0144350773958 53.3114047657587 1.04502587718315 0.0635386671114994 0.884437881734888 1 0.0921566 0.0797097 0.0936499 0.0979388 GeneID:221264,Genbank:XM_011535552.3,HGNC:HGNC:33814,MIM:615358 adenylate kinase 9 GO:0004550,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006174,GO:0006186,GO:0006756,GO:0006757,GO:0015949,GO:0019206,GO:0031965,GO:0050145,GO:0061508,GO:0061565,GO:0061566,GO:0061567,GO:0061568,GO:0061569,GO:0061570,GO:0061571 nucleoside diphosphate kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|dADP phosphorylation|dGDP phosphorylation|AMP phosphorylation|ATP generation from ADP|nucleobase-containing small molecule interconversion|nucleoside kinase activity|nuclear membrane|nucleoside phosphate kinase activity|CDP phosphorylation|dAMP phosphorylation|CMP phosphorylation|dCMP phosphorylation|GDP phosphorylation|UDP phosphorylation|dCDP phosphorylation|TDP phosphorylation hsa00230,hsa00240 Purine metabolism|Pyrimidine metabolism AKAP1 1728.40910539258 1791.67729318302 1665.14091760215 0.929375465067111 -0.105666535785685 0.46098346180973 1 13.3633 13.1049 12.3297 12.5275 GeneID:8165,Genbank:NM_003488.3,HGNC:HGNC:367,MIM:602449 A-kinase anchoring protein 1 GO:0003723,GO:0005739,GO:0005741,GO:0005829,GO:0007596,GO:0010738,GO:0016020,GO:0016021,GO:0034237 RNA binding|mitochondrion|mitochondrial outer membrane|cytosol|blood coagulation|regulation of protein kinase A signaling|membrane|integral component of membrane|protein kinase A regulatory subunit binding AKAP10 868.405924070026 875.088572748757 861.723275391295 0.984726920481341 -0.0222043957896618 0.876873707816154 1 7.636 8.61933 8.71134 7.213 GeneID:11216,Genbank:NM_001330152.1,HGNC:HGNC:368,MIM:604694 A-kinase anchoring protein 10 GO:0005739,GO:0005829,GO:0005886,GO:0007165,GO:0007596,GO:0008104,GO:0043234,GO:0051018 mitochondrion|cytosol|plasma membrane|signal transduction|blood coagulation|protein localization|protein complex|protein kinase A binding AKAP11 189.000616833685 185.060625492832 192.940608174538 1.04258054710839 0.0601588469072294 0.901251601158456 1 0.816237 0.708687 1.09824 0.504855 GeneID:11215,Genbank:XM_011534906.2,HGNC:HGNC:369,MIM:604696 A-kinase anchoring protein 11 GO:0005730,GO:0005777,GO:0005815,GO:0005829,GO:0005886,GO:0008157,GO:0010738,GO:0035556,GO:0051018 nucleolus|peroxisome|microtubule organizing center|cytosol|plasma membrane|protein phosphatase 1 binding|regulation of protein kinase A signaling|intracellular signal transduction|protein kinase A binding AKAP12 3022.01137524497 3149.91400397508 2894.10874651487 0.918789764692815 -0.122193309687814 0.614470898668306 1 9.72006 8.43531 9.96528 7.00935 GeneID:9590,Genbank:XM_017011517.2,HGNC:HGNC:370,MIM:604698 A-kinase anchoring protein 12 AKAP13 1828.11423552227 1760.56266348628 1895.66580755826 1.07673861707623 0.106668071966607 0.649660204437753 1 4.25844 4.10605 5.48088 3.71552 GeneID:11214,Genbank:NM_007200.4,HGNC:HGNC:371,MIM:604686 A-kinase anchoring protein 13 GO:0004691,GO:0004871,GO:0005078,GO:0005085,GO:0005089,GO:0005634,GO:0005829,GO:0005884,GO:0005938,GO:0007186,GO:0007507,GO:0010611,GO:0016020,GO:0017048,GO:0032947,GO:0035025,GO:0035556,GO:0043065,GO:0043123,GO:0043406,GO:0046872,GO:0048471,GO:0051018,GO:0051056,GO:0051168,GO:0055007,GO:0060297,GO:0060348,GO:0071875,GO:0086023,GO:1900169 cAMP-dependent protein kinase activity|signal transducer activity|MAP-kinase scaffold activity|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|nucleus|cytosol|actin filament|cell cortex|G-protein coupled receptor signaling pathway|heart development|regulation of cardiac muscle hypertrophy|membrane|Rho GTPase binding|protein complex scaffold activity|positive regulation of Rho protein signal transduction|intracellular signal transduction|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|metal ion binding|perinuclear region of cytoplasm|protein kinase A binding|regulation of small GTPase mediated signal transduction|nuclear export|cardiac muscle cell differentiation|regulation of sarcomere organization|bone development|adrenergic receptor signaling pathway|adrenergic receptor signaling pathway involved in heart process|regulation of glucocorticoid mediated signaling pathway hsa04928,hsa05163 Parathyroid hormone synthesis, secretion and action|Human cytomegalovirus infection AKAP14 1.51530394484523 2.54640955915669 0.484198330533773 0.190149431693984 -2.39479446774372 0.50238275309926 1 0.0858113 0.0402792 0 0.0379349 GeneID:158798,Genbank:NM_178813.5,HGNC:HGNC:24061,MIM:300462 A-kinase anchoring protein 14 GO:0005930,GO:0005952,GO:0034237 axoneme|cAMP-dependent protein kinase complex|protein kinase A regulatory subunit binding AKAP17A 4.780941336774 6.169014471598 3.39286820195 0.549985450280703 -0.862534641860114 0.57875439465467 1 0.0146929 0.0253589 0.0135781 0.0506568 GeneID:8227,Genbank:NM_005088.2,HGNC:HGNC:18783,MIM:465000 A-kinase anchoring protein 17A GO:0003723,GO:0005634,GO:0005681,GO:0005829,GO:0006355,GO:0006397,GO:0007165,GO:0008380,GO:0016607,GO:0042113,GO:0043484,GO:0051018 RNA binding|nucleus|spliceosomal complex|cytosol|regulation of transcription, DNA-templated|mRNA processing|signal transduction|RNA splicing|nuclear speck|B cell activation|regulation of RNA splicing|protein kinase A binding AKAP2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 14.5265 14.4529 14.1069 12.2388 GeneID:11217,Genbank:NM_001198656.1,HGNC:HGNC:372,MIM:604582 A-kinase anchoring protein 2 AKAP3 10.4432306244776 9.253521707397 11.6329395415581 1.25713646213842 0.330141262777262 0.753545771032627 1 0.0818799 0.0760517 0.12145 0.0808209 GeneID:10566,Genbank:NM_006422.3,HGNC:HGNC:373,MIM:604689 A-kinase anchoring protein 3 GO:0001669,GO:0005634,GO:0005737,GO:0006928,GO:0007178,GO:0007338,GO:0007340,GO:0008104,GO:0010738,GO:0035686,GO:0051018,GO:0097228 acrosomal vesicle|nucleus|cytoplasm|movement of cell or subcellular component|transmembrane receptor protein serine/threonine kinase signaling pathway|single fertilization|acrosome reaction|protein localization|regulation of protein kinase A signaling|sperm fibrous sheath|protein kinase A binding|sperm principal piece AKAP5 56.7652680589551 68.4452831389052 45.0852529790049 0.658705040163357 -0.602295505760938 0.17301011744633 1 0.443555 0.421072 0.391225 0.178819 GeneID:9495,Genbank:NM_004857.3,HGNC:HGNC:375,MIM:604688 A-kinase anchoring protein 5 GO:0005516,GO:0005829,GO:0005886,GO:0006605,GO:0007165,GO:0007193,GO:0007268,GO:0008179,GO:0010738,GO:0017124,GO:0030346,GO:0034237,GO:0035254,GO:0051018,GO:0097110 calmodulin binding|cytosol|plasma membrane|protein targeting|signal transduction|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|chemical synaptic transmission|adenylate cyclase binding|regulation of protein kinase A signaling|SH3 domain binding|protein phosphatase 2B binding|protein kinase A regulatory subunit binding|glutamate receptor binding|protein kinase A binding|scaffold protein binding AKAP6 142.464603997746 123.514559600907 161.414648394586 1.30684713539958 0.386090395992733 0.344428741041554 1 0.252986 0.19193 0.359765 0.217402 GeneID:9472,Genbank:XM_024449755.1,HGNC:HGNC:376,MIM:604691 A-kinase anchoring protein 6 GO:0001508,GO:0005635,GO:0005737,GO:0005901,GO:0006605,GO:0008179,GO:0010738,GO:0010880,GO:0014701,GO:0014704,GO:0016529,GO:0019933,GO:0030307,GO:0030315,GO:0031965,GO:0032516,GO:0032947,GO:0034237,GO:0034704,GO:0035556,GO:0043495,GO:0044325,GO:0048471,GO:0051018,GO:0051281,GO:0060306,GO:0060316,GO:0061051,GO:0070886,GO:0071320,GO:0071345,GO:1901381,GO:1902261 action potential|nuclear envelope|cytoplasm|caveola|protein targeting|adenylate cyclase binding|regulation of protein kinase A signaling|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|junctional sarcoplasmic reticulum membrane|intercalated disc|sarcoplasmic reticulum|cAMP-mediated signaling|positive regulation of cell growth|T-tubule|nuclear membrane|positive regulation of phosphoprotein phosphatase activity|protein complex scaffold activity|protein kinase A regulatory subunit binding|calcium channel complex|intracellular signal transduction|protein membrane anchor|ion channel binding|perinuclear region of cytoplasm|protein kinase A binding|positive regulation of release of sequestered calcium ion into cytosol|regulation of membrane repolarization|positive regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of cell growth involved in cardiac muscle cell development|positive regulation of calcineurin-NFAT signaling cascade|cellular response to cAMP|cellular response to cytokine stimulus|positive regulation of potassium ion transmembrane transport|positive regulation of delayed rectifier potassium channel activity AKAP7 124.729248894608 133.123882541314 116.334615247901 0.873882379533196 -0.19448898207616 0.5366269887963 1 0.60931 0.745922 0.689023 0.431092 GeneID:9465,Genbank:XM_017011509.1,HGNC:HGNC:377,MIM:604693 A-kinase anchoring protein 7 GO:0001508,GO:0005622,GO:0005886,GO:0006811,GO:0008104,GO:0016324,GO:0016328,GO:0035556,GO:0051018,GO:0060306,GO:0071320,GO:1901381,GO:1902261 action potential|intracellular|plasma membrane|ion transport|protein localization|apical plasma membrane|lateral plasma membrane|intracellular signal transduction|protein kinase A binding|regulation of membrane repolarization|cellular response to cAMP|positive regulation of potassium ion transmembrane transport|positive regulation of delayed rectifier potassium channel activity AKAP8 1152.93858267509 1194.65603409366 1111.22113125652 0.930159895019122 -0.104449357244088 0.494313741802633 1 9.08156 8.51601 8.40275 8.42195 GeneID:10270,Genbank:NM_005858.3,HGNC:HGNC:378,MIM:604692 A-kinase anchoring protein 8 GO:0000278,GO:0000793,GO:0001939,GO:0003690,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0005794,GO:0006351,GO:0006355,GO:0007076,GO:0007165,GO:0008270,GO:0015031,GO:0016020,GO:0016363,GO:0031065,GO:0032720,GO:0033127,GO:0034237,GO:0042826,GO:0044839,GO:0045087,GO:0051059,GO:0071222,GO:0071380 mitotic cell cycle|condensed chromosome|female pronucleus|double-stranded DNA binding|RNA binding|nucleus|nucleoplasm|nucleolus|mitochondrion|Golgi apparatus|transcription, DNA-templated|regulation of transcription, DNA-templated|mitotic chromosome condensation|signal transduction|zinc ion binding|protein transport|membrane|nuclear matrix|positive regulation of histone deacetylation|negative regulation of tumor necrosis factor production|regulation of histone phosphorylation|protein kinase A regulatory subunit binding|histone deacetylase binding|cell cycle G2/M phase transition|innate immune response|NF-kappaB binding|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus AKAP8L 1455.97874420379 1443.59944663033 1468.35804177726 1.01715059894539 0.0245332999098083 0.878546049838404 1 11.084 11.6139 11.6677 12.1359 GeneID:26993,Genbank:NM_001291478.1,HGNC:HGNC:29857,MIM:609475 A-kinase anchoring protein 8 like GO:0000785,GO:0003677,GO:0003723,GO:0005521,GO:0005634,GO:0005737,GO:0006351,GO:0006397,GO:0007076,GO:0008380,GO:0010793,GO:0016363,GO:0016605,GO:0016607,GO:0017151,GO:0030529,GO:0031065,GO:0033127,GO:0034237,GO:0042826,GO:0044839,GO:0045944,GO:0046872,GO:0051081 chromatin|DNA binding|RNA binding|lamin binding|nucleus|cytoplasm|transcription, DNA-templated|mRNA processing|mitotic chromosome condensation|RNA splicing|regulation of mRNA export from nucleus|nuclear matrix|PML body|nuclear speck|DEAD/H-box RNA helicase binding|intracellular ribonucleoprotein complex|positive regulation of histone deacetylation|regulation of histone phosphorylation|protein kinase A regulatory subunit binding|histone deacetylase binding|cell cycle G2/M phase transition|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|nuclear envelope disassembly AKAP9 107.598236496291 117.777781601473 97.4186913911086 0.827139805712642 -0.27379689612971 0.533155621812547 1 0.222546 0.148901 0.178899 0.134768 GeneID:10142,Genbank:XM_017011642.2,HGNC:HGNC:379,MIM:604001 A-kinase anchoring protein 9 AKIP1 1167.14843368527 1168.81855396057 1165.47831340996 0.997142207796667 -0.00412882511577536 0.969612693342473 1 10.9212 12.4907 11.9092 12.3884 GeneID:56672,Genbank:XM_017018012.2,HGNC:HGNC:1170,MIM:609191 A-kinase interacting protein 1 GO:0005654,GO:0034446,GO:1901222 nucleoplasm|substrate adhesion-dependent cell spreading|regulation of NIK/NF-kappaB signaling AKIRIN1 1944.68707732369 1789.42884992708 2099.94530472031 1.17352824886325 0.230852570454529 0.101313172071262 1 29.9418 30.5335 37.754 34.0754 GeneID:79647,Genbank:NM_024595.2,HGNC:HGNC:25744,MIM:615164 akirin 1 GO:0005634,GO:0005654,GO:0031965 nucleus|nucleoplasm|nuclear membrane AKIRIN2 1729.30705916769 1700.45840283576 1758.15571549962 1.03393044638296 0.0481391372645934 0.734561199361421 1 45.5403 44.7162 45.6419 47.8301 GeneID:55122,Genbank:NM_018064.3,HGNC:HGNC:21407,MIM:615165 akirin 2 GO:0000122,GO:0005634,GO:0005654,GO:0006351,GO:0008284,GO:0009790,GO:0010950,GO:0017053,GO:0019899,GO:0032496,GO:0032755,GO:0045087,GO:0045944 negative regulation of transcription from RNA polymerase II promoter|nucleus|nucleoplasm|transcription, DNA-templated|positive regulation of cell proliferation|embryo development|positive regulation of endopeptidase activity|transcriptional repressor complex|enzyme binding|response to lipopolysaccharide|positive regulation of interleukin-6 production|innate immune response|positive regulation of transcription from RNA polymerase II promoter AKNA 220.963719285839 212.216466354335 229.710972217343 1.08243708023014 0.114283166588808 0.625649408873627 1 0.757043 0.94237 0.966608 0.902227 GeneID:80709,Genbank:XM_005252244.2,HGNC:HGNC:24108,MIM:605729 AT-hook transcription factor GO:0000978,GO:0001077,GO:0001650,GO:0005654,GO:0005813,GO:0005829,GO:0016020,GO:0043231,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|fibrillar center|nucleoplasm|centrosome|cytosol|membrane|intracellular membrane-bounded organelle|positive regulation of transcription from RNA polymerase II promoter AKNAD1 14.2472923126002 14.4423933750803 14.0521912501202 0.972982170279798 -0.0395147267613434 1 1 0.070432 0.0667997 0.0384747 0.0717458 GeneID:254268,Genbank:NM_152763.4,HGNC:HGNC:28398 AKNA domain containing 1 AKR1A1 1737.9297770818 1545.77341261003 1930.08614155357 1.24862164519613 0.320336380635094 0.121018247996768 1 33.2617 34.5701 40.9808 46.9696 GeneID:10327,Genbank:XM_011540492.2,HGNC:HGNC:380,MIM:103830 aldo-keto reductase family 1 member A1 GO:0004032,GO:0004033,GO:0005615,GO:0005829,GO:0006006,GO:0006081,GO:0009055,GO:0016324,GO:0019640,GO:0019853,GO:0042840,GO:0046185,GO:0047939,GO:0070062,GO:1901687 alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|extracellular space|cytosol|glucose metabolic process|cellular aldehyde metabolic process|electron transfer activity|apical plasma membrane|glucuronate catabolic process to xylulose 5-phosphate|L-ascorbic acid biosynthetic process|D-glucuronate catabolic process|aldehyde catabolic process|L-glucuronate reductase activity|extracellular exosome|glutathione derivative biosynthetic process hsa00010,hsa00040,hsa00561 Glycolysis / Gluconeogenesis|Pentose and glucuronate interconversions|Glycerolipid metabolism AKR1B1 12944.807568915 13398.8996196182 12490.7155182119 0.932219501064357 -0.101258402012039 0.410595406218641 1 159.109 181.694 165.96 160.016 GeneID:231,Genbank:NM_001346142.1,HGNC:HGNC:381,MIM:103880 aldo-keto reductase family 1 member B GO:0001894,GO:0003091,GO:0004032,GO:0004033,GO:0005615,GO:0005654,GO:0005829,GO:0005975,GO:0006061,GO:0006700,GO:0006950,GO:0009055,GO:0009414,GO:0018931,GO:0031098,GO:0032838,GO:0033010,GO:0035809,GO:0042415,GO:0042629,GO:0043066,GO:0043220,GO:0043795,GO:0044597,GO:0044598,GO:0046370,GO:0046427,GO:0048471,GO:0048661,GO:0060135,GO:0070062,GO:0072061,GO:0097066,GO:0097238,GO:0097454,GO:1901653 tissue homeostasis|renal water homeostasis|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|extracellular space|nucleoplasm|cytosol|carbohydrate metabolic process|sorbitol biosynthetic process|C21-steroid hormone biosynthetic process|response to stress|electron transfer activity|response to water deprivation|naphthalene metabolic process|stress-activated protein kinase signaling cascade|plasma membrane bounded cell projection cytoplasm|paranodal junction|regulation of urine volume|norepinephrine metabolic process|mast cell granule|negative regulation of apoptotic process|Schmidt-Lanterman incisure|glyceraldehyde oxidoreductase activity|daunorubicin metabolic process|doxorubicin metabolic process|fructose biosynthetic process|positive regulation of JAK-STAT cascade|perinuclear region of cytoplasm|positive regulation of smooth muscle cell proliferation|maternal process involved in female pregnancy|extracellular exosome|inner medullary collecting duct development|response to thyroid hormone|cellular response to methylglyoxal|Schwann cell microvillus|cellular response to peptide hsa00040,hsa00051,hsa00052,hsa00561,hsa00790 Pentose and glucuronate interconversions|Fructose and mannose metabolism|Galactose metabolism|Glycerolipid metabolism|Folate biosynthesis AKR1B10 93.6636015939199 73.4518583629567 113.875344824883 1.55033987380111 0.632584525497326 0.0416677979712467 0.762892637318431 0.58075 1.00765 1.16604 1.54563 GeneID:57016,Genbank:NM_020299.4,HGNC:HGNC:382,MIM:604707 aldo-keto reductase family 1 member B10 GO:0001523,GO:0001758,GO:0004033,GO:0005764,GO:0005829,GO:0006081,GO:0007586,GO:0008202,GO:0016488,GO:0044597,GO:0044598,GO:0045550,GO:0047718,GO:0070062 retinoid metabolic process|retinal dehydrogenase activity|aldo-keto reductase (NADP) activity|lysosome|cytosol|cellular aldehyde metabolic process|digestion|steroid metabolic process|farnesol catabolic process|daunorubicin metabolic process|doxorubicin metabolic process|geranylgeranyl reductase activity|indanol dehydrogenase activity|extracellular exosome hsa00040,hsa00051,hsa00052,hsa00561,hsa00790 Pentose and glucuronate interconversions|Fructose and mannose metabolism|Galactose metabolism|Glycerolipid metabolism|Folate biosynthesis AKR1B15 1.48672269415927 1.51824048055703 1.45520490776151 0.958481167112346 -0.0611780097655067 1 1 0 0.0124092 0.0127582 0 GeneID:441282,Genbank:NM_001080538.2,HGNC:HGNC:37281,MIM:616336 aldo-keto reductase family 1 member B15 GO:0004303,GO:0005739,GO:0005759,GO:0005829,GO:0006703,GO:0016616 estradiol 17-beta-dehydrogenase activity|mitochondrion|mitochondrial matrix|cytosol|estrogen biosynthetic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C1 305.574723203176 211.342184754898 399.807261651454 1.89175323476062 0.919723912036004 5.22755994669303e-06 0.00299016428950842 2.15417 2.71891 4.6445 4.59778 GeneID:1645,Genbank:NM_001353.5,HGNC:HGNC:384,MIM:600449 aldo-keto reductase family 1 member C1 GO:0001523,GO:0004032,GO:0004033,GO:0005829,GO:0006805,GO:0007586,GO:0008206,GO:0015721,GO:0016655,GO:0018636,GO:0030299,GO:0030855,GO:0031406,GO:0032052,GO:0042448,GO:0042574,GO:0042632,GO:0044597,GO:0044598,GO:0046683,GO:0047006,GO:0047042,GO:0047086,GO:0047115,GO:0047718,GO:0051260,GO:0055114,GO:0070062,GO:0071395 retinoid metabolic process|alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|cytosol|xenobiotic metabolic process|digestion|bile acid metabolic process|bile acid and bile salt transport|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phenanthrene 9,10-monooxygenase activity|intestinal cholesterol absorption|epithelial cell differentiation|carboxylic acid binding|bile acid binding|progesterone metabolic process|retinal metabolic process|cholesterol homeostasis|daunorubicin metabolic process|doxorubicin metabolic process|response to organophosphorus|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|androsterone dehydrogenase (B-specific) activity|ketosteroid monooxygenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|indanol dehydrogenase activity|protein homooligomerization|oxidation-reduction process|extracellular exosome|cellular response to jasmonic acid stimulus hsa00140,hsa00980 Steroid hormone biosynthesis|Metabolism of xenobiotics by cytochrome P450 AKR1C2 21.5563578489621 16.940776659552 26.1719390383723 1.54490786132968 0.62752079802182 0.313617510858605 1 0.115566 0.160449 0.232246 0.169264 GeneID:1646,Genbank:NM_205845.2,HGNC:HGNC:385,MIM:600450 aldo-keto reductase family 1 member C2 GO:0004032,GO:0005737,GO:0006693,GO:0007186,GO:0007586,GO:0008202,GO:0008284,GO:0016655,GO:0018636,GO:0030855,GO:0031406,GO:0032052,GO:0042448,GO:0044597,GO:0044598,GO:0047086,GO:0047115,GO:0051897,GO:0055114,GO:0071395,GO:0071799 alditol:NADP+ 1-oxidoreductase activity|cytoplasm|prostaglandin metabolic process|G-protein coupled receptor signaling pathway|digestion|steroid metabolic process|positive regulation of cell proliferation|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phenanthrene 9,10-monooxygenase activity|epithelial cell differentiation|carboxylic acid binding|bile acid binding|progesterone metabolic process|daunorubicin metabolic process|doxorubicin metabolic process|ketosteroid monooxygenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|positive regulation of protein kinase B signaling|oxidation-reduction process|cellular response to jasmonic acid stimulus|cellular response to prostaglandin D stimulus hsa00140,hsa05204 Steroid hormone biosynthesis|Chemical carcinogenesis AKR1C3 524.947983061938 433.926585789491 615.969380334386 1.41952440921241 0.505407656915019 0.00365478654506711 0.23228198930871 6.15841 7.43986 10.2195 9.24185 GeneID:8644,Genbank:NM_001253908.1,HGNC:HGNC:386,MIM:603966 aldo-keto reductase family 1 member C3 hsa00140,hsa00590,hsa00790,hsa04913 Steroid hormone biosynthesis|Arachidonic acid metabolism|Folate biosynthesis|Ovarian steroidogenesis AKR7A2 1186.6996398287 1146.36253036565 1227.03674929175 1.07037408916389 0.0981150978042628 0.526310656715732 1 16.8364 17.5359 18.4948 18.9678 GeneID:8574,Genbank:NM_001320979.1,HGNC:HGNC:389,MIM:603418 aldo-keto reductase family 7 member A2 GO:0004032,GO:0004033,GO:0005794,GO:0005829,GO:0005975,GO:0006081,GO:0006805,GO:0009055,GO:0019119,GO:0044597,GO:0044598,GO:0070062 alditol:NADP+ 1-oxidoreductase activity|aldo-keto reductase (NADP) activity|Golgi apparatus|cytosol|carbohydrate metabolic process|cellular aldehyde metabolic process|xenobiotic metabolic process|electron transfer activity|phenanthrene-9,10-epoxide hydrolase activity|daunorubicin metabolic process|doxorubicin metabolic process|extracellular exosome hsa00980 Metabolism of xenobiotics by cytochrome P450 AKR7A3 7.57497401221589 8.36943145285216 6.78051657157961 0.810152590385208 -0.3037344329899 0.879365538883271 1 0.087316 0.0575967 0 0.151764 GeneID:22977,Genbank:XM_011541046.3,HGNC:HGNC:390,MIM:608477 aldo-keto reductase family 7 member A3 GO:0004033,GO:0005829,GO:0006081,GO:0006805,GO:0009055,GO:0042802,GO:0070062 aldo-keto reductase (NADP) activity|cytosol|cellular aldehyde metabolic process|xenobiotic metabolic process|electron transfer activity|identical protein binding|extracellular exosome hsa00980 Metabolism of xenobiotics by cytochrome P450 AKR7L 3.77004235203982 3.18055978516888 4.35952491891075 1.37067850107375 0.454890220060668 0.830458539823272 1 0.0852092 0.0156261 0.0322839 0.104978 GeneID:246181,Genbank:NM_001348421.1,HGNC:HGNC:24056,MIM:608478 aldo-keto reductase family 7 like (gene/pseudogene) GO:0004033,GO:0005829,GO:0006805,GO:0070062 aldo-keto reductase (NADP) activity|cytosol|xenobiotic metabolic process|extracellular exosome AKT1 4647.66021061041 4271.75065728352 5023.5697639373 1.17599789102201 0.233885472916779 0.0818414583570865 0.959570129609882 49.5288 50.1091 60.5976 60.6004 GeneID:207,Genbank:NM_001014431.1,HGNC:HGNC:391,MIM:164730 AKT serine/threonine kinase 1 hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04261,hsa04370,hsa04371,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04722,hsa04725,hsa04728,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04920,hsa04922,hsa04923,hsa04926,hsa04931,hsa04932,hsa04933,hsa04973,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05169,hsa05170,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05418 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Carbohydrate digestion and absorption|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis AKT1S1 2462.02708956059 2319.76523173322 2604.28894738796 1.12265194415478 0.166910718234673 0.238005594957499 1 33.6008 35.1166 37.9354 40.4368 GeneID:84335,Genbank:NM_001278160.1,HGNC:HGNC:28426,MIM:610221 AKT1 substrate 1 GO:0005654,GO:0005737,GO:0005829,GO:0006469,GO:0032007,GO:0038202,GO:0042981,GO:0043234,GO:0043491,GO:0043523,GO:0045792,GO:0048011,GO:1900034 nucleoplasm|cytoplasm|cytosol|negative regulation of protein kinase activity|negative regulation of TOR signaling|TORC1 signaling|regulation of apoptotic process|protein complex|protein kinase B signaling|regulation of neuron apoptotic process|negative regulation of cell size|neurotrophin TRK receptor signaling pathway|regulation of cellular response to heat hsa04140,hsa04150,hsa04152,hsa04211,hsa04213,hsa04714 Autophagy - animal|mTOR signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Thermogenesis AKT2 4357.86660386766 4328.32734857012 4387.4058591652 1.01364927045423 0.0195585563794494 0.888803781255884 1 18.8851 19.0788 20.4512 18.6041 GeneID:208,Genbank:NM_001243028.2,HGNC:HGNC:392,MIM:164731 AKT serine/threonine kinase 2 hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04261,hsa04370,hsa04371,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04722,hsa04725,hsa04728,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04920,hsa04922,hsa04923,hsa04926,hsa04931,hsa04932,hsa04933,hsa04973,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05169,hsa05170,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05418 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Carbohydrate digestion and absorption|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis AKT3 624.891988461469 652.18455409902 597.599422823918 0.916304164316632 -0.126101518932721 0.67068020255467 1 2.91294 2.25167 2.64678 2.06282 GeneID:10000,Genbank:NM_181690.2,HGNC:HGNC:393,MIM:611223 AKT serine/threonine kinase 3 GO:0000002,GO:0004672,GO:0004674,GO:0005524,GO:0005622,GO:0005634,GO:0005737,GO:0005886,GO:0007165,GO:0010765,GO:0018105,GO:0018107,GO:0032008,GO:0032869,GO:0045793,GO:0048854,GO:0048873 mitochondrial genome maintenance|protein kinase activity|protein serine/threonine kinase activity|ATP binding|intracellular|nucleus|cytoplasm|plasma membrane|signal transduction|positive regulation of sodium ion transport|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of TOR signaling|cellular response to insulin stimulus|positive regulation of cell size|brain morphogenesis|homeostasis of number of cells within a tissue hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04261,hsa04370,hsa04371,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04722,hsa04725,hsa04728,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04920,hsa04922,hsa04923,hsa04926,hsa04931,hsa04932,hsa04933,hsa04973,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05169,hsa05170,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05418 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Carbohydrate digestion and absorption|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis AKTIP 508.016407144513 529.929503295885 486.103310993141 0.917298070724185 -0.124537489441135 0.497225668505487 1 7.83554 6.94777 7.40299 5.83453 GeneID:64400,Genbank:XM_005256098.5,HGNC:HGNC:16710,MIM:608483 AKT interacting protein GO:0001934,GO:0005829,GO:0005886,GO:0006915,GO:0007032,GO:0007040,GO:0008333,GO:0015031,GO:0031625,GO:0032092,GO:0045022,GO:0061630,GO:0070695 positive regulation of protein phosphorylation|cytosol|plasma membrane|apoptotic process|endosome organization|lysosome organization|endosome to lysosome transport|protein transport|ubiquitin protein ligase binding|positive regulation of protein binding|early endosome to late endosome transport|ubiquitin protein ligase activity|FHF complex ALAD 796.425820860391 799.042278551958 793.809363168824 0.993451015642605 -0.00947926101254417 0.945807416181538 1 6.65758 7.15425 6.98809 6.95339 GeneID:210,Genbank:NM_000031.5,HGNC:HGNC:395,MIM:125270 aminolevulinate dehydratase hsa00860 Porphyrin and chlorophyll metabolism ALAS1 2612.21546274368 2602.13529280405 2622.29563268332 1.00774761402108 0.0111343674171908 0.940657064080616 1 32.8835 32.4678 35.1753 33.2448 GeneID:211,Genbank:NM_000688.5,HGNC:HGNC:396,MIM:125290 5'-aminolevulinate synthase 1 GO:0003870,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006782,GO:0006783,GO:0007005,GO:0019216,GO:0030170,GO:0042802 5-aminolevulinate synthase activity|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|mitochondrion organization|regulation of lipid metabolic process|pyridoxal phosphate binding|identical protein binding hsa00260,hsa00860 Glycine, serine and threonine metabolism|Porphyrin and chlorophyll metabolism ALB 1.45846806302491 0.980142803914724 1.93679332213509 1.97603177251261 0.982606144127986 0.869541181612543 1 0 0.0381744 0 0.0535033 GeneID:213,Genbank:NM_000477.6,HGNC:HGNC:399,MIM:103600 albumin hsa04918 Thyroid hormone synthesis ALCAM 3755.31760575428 3738.14035279197 3772.49485871659 1.00919026646471 0.0131981968501382 0.946541744447222 1 21.4972 18.4674 24.848 16.1908 GeneID:214,Genbank:NM_001627.3,HGNC:HGNC:400,MIM:601662 activated leukocyte cell adhesion molecule GO:0001772,GO:0002250,GO:0005102,GO:0005887,GO:0005925,GO:0007155,GO:0007157,GO:0007165,GO:0008045,GO:0009897,GO:0030424,GO:0030425,GO:0031226,GO:0031290,GO:0042802,GO:0043025,GO:0048846,GO:0070062,GO:1990138 immunological synapse|adaptive immune response|receptor binding|integral component of plasma membrane|focal adhesion|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|motor neuron axon guidance|external side of plasma membrane|axon|dendrite|intrinsic component of plasma membrane|retinal ganglion cell axon guidance|identical protein binding|neuronal cell body|axon extension involved in axon guidance|extracellular exosome|neuron projection extension hsa04514 Cell adhesion molecules (CAMs) ALDH16A1 1405.37838387046 1355.03486104841 1455.7219066925 1.07430587104319 0.103404808790614 0.650936728907969 1 16.8283 20.206 20.0436 21.8702 GeneID:126133,Genbank:NM_153329.3,HGNC:HGNC:28114,MIM:613358 aldehyde dehydrogenase 16 family member A1 GO:0004029,GO:0016020,GO:0070062 aldehyde dehydrogenase (NAD) activity|membrane|extracellular exosome ALDH18A1 3845.15391195953 3809.51560004009 3880.79222387896 1.01871015407789 0.0267436307415444 0.852802974153549 1 33.4351 34.7841 34.5701 35.5935 GeneID:5832,Genbank:NM_001323419.1,HGNC:HGNC:9722,MIM:138250 aldehyde dehydrogenase 18 family member A1 GO:0003723,GO:0004349,GO:0004350,GO:0005524,GO:0005739,GO:0005743,GO:0005829,GO:0006536,GO:0006561,GO:0006592,GO:0008652,GO:0017084,GO:0019240,GO:0042802,GO:0055129 RNA binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity|ATP binding|mitochondrion|mitochondrial inner membrane|cytosol|glutamate metabolic process|proline biosynthetic process|ornithine biosynthetic process|cellular amino acid biosynthetic process|delta1-pyrroline-5-carboxylate synthetase activity|citrulline biosynthetic process|identical protein binding|L-proline biosynthetic process hsa00330 Arginine and proline metabolism ALDH1A1 3.44839912569023 1.56626675524197 5.33053149613849 3.40333565677641 1.76694944530415 0.332820978353186 1 0.0367503 0.0175721 0.0885108 0.0987313 GeneID:216,Genbank:NM_000689.4,HGNC:HGNC:402,MIM:100640 aldehyde dehydrogenase 1 family member A1 hsa00830 Retinol metabolism ALDH1A2 13.4385142200051 12.338028943196 14.5389994968141 1.17838915468195 0.236816057687205 0.801189791490645 1 0.117915 0.0827619 0.103349 0.104967 GeneID:8854,Genbank:NM_170696.2,HGNC:HGNC:15472,MIM:603687 aldehyde dehydrogenase 1 family member A2 hsa00830 Retinol metabolism ALDH1A3 1278.27074717524 1694.37664925927 862.164845091212 0.508838955888658 -0.974718969634633 5.44096941086476e-11 1.24489380120586e-07 19.0422 20.2441 10.3896 9.79227 GeneID:220,Genbank:NM_000693.3,HGNC:HGNC:409,MIM:600463 aldehyde dehydrogenase 1 family member A3 GO:0001758,GO:0002072,GO:0002138,GO:0004029,GO:0004030,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007626,GO:0021768,GO:0031076,GO:0042472,GO:0042572,GO:0042573,GO:0042574,GO:0042803,GO:0043065,GO:0048048,GO:0050885,GO:0051289,GO:0060013,GO:0060166,GO:0060324,GO:0070062,GO:0070324,GO:0070384,GO:0070403 retinal dehydrogenase activity|optic cup morphogenesis involved in camera-type eye development|retinoic acid biosynthetic process|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase [NAD(P)+] activity|nucleus|cytoplasm|cytosol|plasma membrane|locomotory behavior|nucleus accumbens development|embryonic camera-type eye development|inner ear morphogenesis|retinol metabolic process|retinoic acid metabolic process|retinal metabolic process|protein homodimerization activity|positive regulation of apoptotic process|embryonic eye morphogenesis|neuromuscular process controlling balance|protein homotetramerization|righting reflex|olfactory pit development|face development|extracellular exosome|thyroid hormone binding|Harderian gland development|NAD+ binding hsa00010,hsa00340,hsa00350,hsa00360,hsa00410,hsa00980,hsa00982,hsa05204 Glycolysis / Gluconeogenesis|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ALDH1B1 715.936996627656 779.584518298573 652.289474956739 0.836714249252085 -0.257193090479708 0.104748740688003 1 8.36524 9.69278 7.58674 7.70217 GeneID:219,Genbank:NM_000692.4,HGNC:HGNC:407,MIM:100670 aldehyde dehydrogenase 1 family member B1 GO:0004029,GO:0005654,GO:0005739,GO:0005759,GO:0005975,GO:0006068,GO:0006069,GO:0043231,GO:0051287 aldehyde dehydrogenase (NAD) activity|nucleoplasm|mitochondrion|mitochondrial matrix|carbohydrate metabolic process|ethanol catabolic process|ethanol oxidation|intracellular membrane-bounded organelle|NAD binding hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620 Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism ALDH1L1 1.97298758835144 2.00831188251439 1.93766329418849 0.964821903937823 -0.0516654343909047 1 1 0.0107237 0.00948449 0.0100653 0.0187184 GeneID:10840,Genbank:NM_001270364.1,HGNC:HGNC:3978,MIM:600249 aldehyde dehydrogenase 1 family member L1 GO:0003824,GO:0004029,GO:0005739,GO:0005829,GO:0006730,GO:0009058,GO:0009258,GO:0016155,GO:0016742,GO:0046655,GO:0070062 catalytic activity|aldehyde dehydrogenase (NAD) activity|mitochondrion|cytosol|one-carbon metabolic process|biosynthetic process|10-formyltetrahydrofolate catabolic process|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|folic acid metabolic process|extracellular exosome hsa00670 One carbon pool by folate ALDH1L2 27.369274772101 25.6562006903067 29.0823488538953 1.13354074537166 0.180836250001627 0.767128401894973 1 0.105373 0.109494 0.156926 0.102771 GeneID:160428,Genbank:XM_017018889.1,HGNC:HGNC:26777,MIM:613584 aldehyde dehydrogenase 1 family member L2 GO:0004029,GO:0005634,GO:0005739,GO:0005759,GO:0006730,GO:0009058,GO:0009258,GO:0016155,GO:0016742,GO:0046655,GO:0070062 aldehyde dehydrogenase (NAD) activity|nucleus|mitochondrion|mitochondrial matrix|one-carbon metabolic process|biosynthetic process|10-formyltetrahydrofolate catabolic process|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|folic acid metabolic process|extracellular exosome hsa00670 One carbon pool by folate ALDH2 0.780196841909191 1.07619535328461 0.484198330533773 0.449916763769675 -1.15226997256519 0.981239839765731 1 0.0442622 0 0 0.0193601 GeneID:217,Genbank:NM_000690.3,HGNC:HGNC:404,MIM:100650 aldehyde dehydrogenase 2 family member hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620 Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism ALDH3A1 33.2707137831648 23.4077574343676 43.1336701319621 1.84270835225901 0.881827751899246 0.0790250156224665 0.945231254824065 0.170056 0.23301 0.337746 0.252659 GeneID:218,Genbank:NM_001330150.1,HGNC:HGNC:405,MIM:100660 aldehyde dehydrogenase 3 family member A1 GO:0004028,GO:0004029,GO:0004030,GO:0005615,GO:0005783,GO:0005829,GO:0005886,GO:0006081,GO:0006805,GO:0008106,GO:0016021,GO:0018479,GO:0055114 3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase [NAD(P)+] activity|extracellular space|endoplasmic reticulum|cytosol|plasma membrane|cellular aldehyde metabolic process|xenobiotic metabolic process|alcohol dehydrogenase (NADP+) activity|integral component of membrane|benzaldehyde dehydrogenase (NAD+) activity|oxidation-reduction process hsa00010,hsa00340,hsa00350,hsa00360,hsa00410,hsa00980,hsa00982,hsa05204 Glycolysis / Gluconeogenesis|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ALDH3A2 1954.17873977031 1838.97408779946 2069.38339174116 1.12529230589508 0.170299804543694 0.231521602390909 1 15.8855 16.8166 19.6099 17.9058 GeneID:224,Genbank:XM_011523733.2,HGNC:HGNC:403,MIM:609523 aldehyde dehydrogenase 3 family member A2 GO:0001561,GO:0004029,GO:0004030,GO:0005743,GO:0005777,GO:0005778,GO:0005789,GO:0006081,GO:0006714,GO:0007417,GO:0007422,GO:0008544,GO:0016021,GO:0030148,GO:0033306,GO:0043231,GO:0046577,GO:0050061,GO:0052814,GO:0055114,GO:0070062 fatty acid alpha-oxidation|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase [NAD(P)+] activity|mitochondrial inner membrane|peroxisome|peroxisomal membrane|endoplasmic reticulum membrane|cellular aldehyde metabolic process|sesquiterpenoid metabolic process|central nervous system development|peripheral nervous system development|epidermis development|integral component of membrane|sphingolipid biosynthetic process|phytol metabolic process|intracellular membrane-bounded organelle|long-chain-alcohol oxidase activity|long-chain-aldehyde dehydrogenase activity|medium-chain-aldehyde dehydrogenase activity|oxidation-reduction process|extracellular exosome hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620 Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism ALDH3B1 662.732077607266 645.604954467183 679.859200747349 1.0530575951178 0.0745843441684711 0.743455364856463 1 9.17244 9.95602 9.16213 11.2668 GeneID:221,Genbank:NM_001161473.2,HGNC:HGNC:410,MIM:600466 aldehyde dehydrogenase 3 family member B1 GO:0004028,GO:0004029,GO:0004030,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006068,GO:0006629,GO:0030148,GO:0030667,GO:0031982,GO:0034599,GO:0035579,GO:0043312,GO:0046185,GO:0055114,GO:0070062 3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aldehyde dehydrogenase [NAD(P)+] activity|cytoplasm|cytosol|plasma membrane|alcohol metabolic process|ethanol catabolic process|lipid metabolic process|sphingolipid biosynthetic process|secretory granule membrane|vesicle|cellular response to oxidative stress|specific granule membrane|neutrophil degranulation|aldehyde catabolic process|oxidation-reduction process|extracellular exosome hsa00010,hsa00340,hsa00350,hsa00360,hsa00410,hsa00980,hsa00982,hsa05204 Glycolysis / Gluconeogenesis|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ALDH3B2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0140411 GeneID:222,Genbank:NM_001031615.2,HGNC:HGNC:411,MIM:601917 aldehyde dehydrogenase 3 family member B2 GO:0004028,GO:0004030,GO:0005811,GO:0006066,GO:0006068,GO:0006629,GO:0030148 3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase [NAD(P)+] activity|lipid droplet|alcohol metabolic process|ethanol catabolic process|lipid metabolic process|sphingolipid biosynthetic process hsa00010,hsa00340,hsa00350,hsa00360,hsa00410,hsa00980,hsa00982,hsa05204 Glycolysis / Gluconeogenesis|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis ALDH4A1 596.549025770651 587.324675253834 605.773376287468 1.0314114182682 0.0446199221329231 0.776933248509127 1 6.62621 5.93307 6.73217 6.49231 GeneID:8659,Genbank:NM_001319218.1,HGNC:HGNC:406,MIM:606811 aldehyde dehydrogenase 4 family member A1 GO:0003842,GO:0004029,GO:0005759,GO:0006560,GO:0006562,GO:0009055,GO:0010133,GO:0019470,GO:0042802,GO:0046487 1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|mitochondrial matrix|proline metabolic process|proline catabolic process|electron transfer activity|proline catabolic process to glutamate|4-hydroxyproline catabolic process|identical protein binding|glyoxylate metabolic process hsa00250,hsa00330 Alanine, aspartate and glutamate metabolism|Arginine and proline metabolism ALDH5A1 430.903947743921 418.830424878183 442.977470609659 1.05765351392153 0.0808670796095642 0.663527902140347 1 3.28143 3.27489 3.90933 3.18586 GeneID:7915,Genbank:NM_170740.1,HGNC:HGNC:408,MIM:610045 aldehyde dehydrogenase 5 family member A1 GO:0004777,GO:0005739,GO:0005759,GO:0006006,GO:0006083,GO:0006105,GO:0006536,GO:0006540,GO:0006541,GO:0006650,GO:0006678,GO:0006681,GO:0006749,GO:0007417,GO:0009013,GO:0009450,GO:0009791,GO:0022904,GO:0042135,GO:0042803,GO:0046459,GO:0051287,GO:0051289 succinate-semialdehyde dehydrogenase (NAD+) activity|mitochondrion|mitochondrial matrix|glucose metabolic process|acetate metabolic process|succinate metabolic process|glutamate metabolic process|glutamate decarboxylation to succinate|glutamine metabolic process|glycerophospholipid metabolic process|glucosylceramide metabolic process|galactosylceramide metabolic process|glutathione metabolic process|central nervous system development|succinate-semialdehyde dehydrogenase [NAD(P)+] activity|gamma-aminobutyric acid catabolic process|post-embryonic development|respiratory electron transport chain|neurotransmitter catabolic process|protein homodimerization activity|short-chain fatty acid metabolic process|NAD binding|protein homotetramerization hsa00250,hsa00650 Alanine, aspartate and glutamate metabolism|Butanoate metabolism ALDH6A1 292.452839785211 257.311826988665 327.593852581757 1.27313950709381 0.348390514419878 0.0876256522279458 0.970036792388817 1.84176 2.14661 2.47113 2.66168 GeneID:4329,Genbank:NM_001278593.1,HGNC:HGNC:7179,MIM:603178 aldehyde dehydrogenase 6 family member A1 GO:0000062,GO:0003723,GO:0004491,GO:0005654,GO:0005739,GO:0005759,GO:0006210,GO:0006573,GO:0006574,GO:0009083,GO:0018478,GO:0019859,GO:0050873,GO:0070062 fatty-acyl-CoA binding|RNA binding|methylmalonate-semialdehyde dehydrogenase (acylating) activity|nucleoplasm|mitochondrion|mitochondrial matrix|thymine catabolic process|valine metabolic process|valine catabolic process|branched-chain amino acid catabolic process|malonate-semialdehyde dehydrogenase (acetylating) activity|thymine metabolic process|brown fat cell differentiation|extracellular exosome hsa00280,hsa00410,hsa00562,hsa00640 Valine, leucine and isoleucine degradation|beta-Alanine metabolism|Inositol phosphate metabolism|Propanoate metabolism ALDH7A1 2966.18585104638 2715.52103209727 3216.85066999549 1.18461637084469 0.244419928754627 0.0719795756178257 0.928200388965456 17.5366 17.7284 20.9356 21.2114 GeneID:501,Genbank:NM_001202404.1,HGNC:HGNC:877,MIM:107323 aldehyde dehydrogenase 7 family member A1 GO:0004029,GO:0004043,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0006081,GO:0006554,GO:0007605,GO:0008802,GO:0019285,GO:0042426,GO:0070062 aldehyde dehydrogenase (NAD) activity|L-aminoadipate-semialdehyde dehydrogenase activity|nucleus|mitochondrion|mitochondrial matrix|cytosol|cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound|betaine-aldehyde dehydrogenase activity|glycine betaine biosynthetic process from choline|choline catabolic process|extracellular exosome hsa00010,hsa00053,hsa00071,hsa00260,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620 Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Glycine, serine and threonine metabolism|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism ALDH8A1 5.15277286174722 3.03648096111406 7.26906476238037 2.39391086440846 1.25936943554376 0.380903593245991 1 0.0362992 0.0666367 0.120185 0.127647 GeneID:64577,Genbank:NM_001193480.1,HGNC:HGNC:15471,MIM:606467 aldehyde dehydrogenase 8 family member A1 GO:0001758,GO:0005622,GO:0005829,GO:0042573,GO:0042574,GO:0042904,GO:0070062 retinal dehydrogenase activity|intracellular|cytosol|retinoic acid metabolic process|retinal metabolic process|9-cis-retinoic acid biosynthetic process|extracellular exosome ALDH9A1 1348.90933013296 1357.35770554179 1340.46095472413 0.987551733232383 -0.0180717686617771 0.898919654216879 1 17.9827 19.0165 18.3806 18.0866 GeneID:223,Genbank:NM_000696.3,HGNC:HGNC:412,MIM:602733 aldehyde dehydrogenase 9 family member A1 GO:0004028,GO:0004029,GO:0005737,GO:0005829,GO:0006081,GO:0019145,GO:0033737,GO:0042136,GO:0042445,GO:0045329,GO:0047105,GO:0055114,GO:0070062 3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|cytoplasm|cytosol|cellular aldehyde metabolic process|aminobutyraldehyde dehydrogenase activity|1-pyrroline dehydrogenase activity|neurotransmitter biosynthetic process|hormone metabolic process|carnitine biosynthetic process|4-trimethylammoniobutyraldehyde dehydrogenase activity|oxidation-reduction process|extracellular exosome hsa00010,hsa00053,hsa00071,hsa00280,hsa00310,hsa00330,hsa00340,hsa00380,hsa00410,hsa00561,hsa00620 Glycolysis / Gluconeogenesis|Ascorbate and aldarate metabolism|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Arginine and proline metabolism|Histidine metabolism|Tryptophan metabolism|beta-Alanine metabolism|Glycerolipid metabolism|Pyruvate metabolism ALDOA 36059.3644638982 32940.7212056685 39178.0077221279 1.18934881472438 0.250171893780941 0.0541116352125915 0.849526737634191 326.724 339.682 394.011 417.776 GeneID:226,Genbank:NM_001355564.1,HGNC:HGNC:414,MIM:103850 aldolase, fructose-bisphosphate A GO:0002576,GO:0003723,GO:0003779,GO:0004332,GO:0005576,GO:0005615,GO:0005634,GO:0005829,GO:0006000,GO:0006094,GO:0006096,GO:0006754,GO:0006941,GO:0007015,GO:0007339,GO:0008092,GO:0008360,GO:0015629,GO:0015631,GO:0016020,GO:0030388,GO:0031093,GO:0031430,GO:0031674,GO:0034774,GO:0042802,GO:0043312,GO:0045296,GO:0046716,GO:0051289,GO:0061621,GO:0061827,GO:0070061,GO:0070062,GO:1904724,GO:1904813 platelet degranulation|RNA binding|actin binding|fructose-bisphosphate aldolase activity|extracellular region|extracellular space|nucleus|cytosol|fructose metabolic process|gluconeogenesis|glycolytic process|ATP biosynthetic process|striated muscle contraction|actin filament organization|binding of sperm to zona pellucida|cytoskeletal protein binding|regulation of cell shape|actin cytoskeleton|tubulin binding|membrane|fructose 1,6-bisphosphate metabolic process|platelet alpha granule lumen|M band|I band|secretory granule lumen|identical protein binding|neutrophil degranulation|cadherin binding|muscle cell cellular homeostasis|protein homotetramerization|canonical glycolysis|sperm head|fructose binding|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen hsa00010,hsa00030,hsa00051,hsa04066 Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|HIF-1 signaling pathway ALDOC 19.5486133399295 17.7768406394119 21.3203860404472 1.19933493655667 0.262234614406994 0.731066542772075 1 0.299952 0.362446 0.407568 0.473031 GeneID:230,Genbank:XM_005257949.2,HGNC:HGNC:418,MIM:103870 aldolase, fructose-bisphosphate C GO:0004332,GO:0005576,GO:0005739,GO:0005829,GO:0005856,GO:0006000,GO:0006094,GO:0008092,GO:0030388,GO:0030855,GO:0034774,GO:0043312,GO:0061621,GO:0070062,GO:1904724,GO:1904813 fructose-bisphosphate aldolase activity|extracellular region|mitochondrion|cytosol|cytoskeleton|fructose metabolic process|gluconeogenesis|cytoskeletal protein binding|fructose 1,6-bisphosphate metabolic process|epithelial cell differentiation|secretory granule lumen|neutrophil degranulation|canonical glycolysis|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen hsa00010,hsa00030,hsa00051 Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism ALG1 908.305441333174 893.423128375027 923.187754291322 1.03331526235551 0.047280484644754 0.785422589023997 1 8.1148 9.28924 9.11522 9.08849 GeneID:56052,Genbank:NM_019109.4,HGNC:HGNC:18294,MIM:605907 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase GO:0000030,GO:0004578,GO:0005783,GO:0005789,GO:0006486,GO:0006488,GO:0016020,GO:0016021 mannosyltransferase activity|chitobiosyldiphosphodolichol beta-mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane|integral component of membrane hsa00510 N-Glycan biosynthesis ALG10 117.856669127452 126.176639019649 109.536699235254 0.868121865396937 -0.204030515048288 0.469722642314656 1 0.57077 0.619197 0.567401 0.43933 GeneID:84920,Genbank:NM_032834.3,HGNC:HGNC:23162,MIM:603313 ALG10, alpha-1,2-glucosyltransferase GO:0004583,GO:0005789,GO:0006486,GO:0006488,GO:0016021,GO:0106073 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity hsa00510 N-Glycan biosynthesis ALG10B 119.086540955098 113.13681626554 125.036265644655 1.10517751667314 0.144278117901748 0.586565022304878 1 0.615619 0.486647 0.654343 0.600494 GeneID:144245,Genbank:XM_005268665.4,HGNC:HGNC:31088 ALG10B, alpha-1,2-glucosyltransferase GO:0004583,GO:0005783,GO:0005789,GO:0005886,GO:0006486,GO:0006488,GO:0016021,GO:0016740,GO:0060050,GO:0106073,GO:1901980 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|transferase activity|positive regulation of protein glycosylation|dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity|positive regulation of inward rectifier potassium channel activity hsa00510 N-Glycan biosynthesis ALG11 77.7605045472461 84.2716468255956 71.2493622688966 0.845472527863976 -0.242170217316934 0.461233352485792 1 2.25375 2.28949 2.49733 1.61898 GeneID:440138,Genbank:NM_001004127.2,HGNC:HGNC:32456,MIM:613666 ALG11, alpha-1,2-mannosyltransferase GO:0004377,GO:0005789,GO:0006490,GO:0016020,GO:0016021,GO:0033577 GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity|endoplasmic reticulum membrane|oligosaccharide-lipid intermediate biosynthetic process|membrane|integral component of membrane|protein glycosylation in endoplasmic reticulum hsa00510 N-Glycan biosynthesis ALG12 475.210240709769 488.563625779328 461.856855640209 0.94533614716708 -0.0811006738934262 0.640199681789031 1 7.15978 7.49992 7.5162 7.1264 GeneID:79087,Genbank:XM_017028936.1,HGNC:HGNC:19358,MIM:607144 ALG12, alpha-1,6-mannosyltransferase GO:0000030,GO:0005783,GO:0005789,GO:0006457,GO:0006487,GO:0006488,GO:0016020,GO:0016021,GO:0052917 mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane|integral component of membrane|dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity hsa00510 N-Glycan biosynthesis ALG13 672.79469766105 706.361965653079 639.227429669022 0.904957317567365 -0.144078345991004 0.387226209635274 1 1.56549 1.56972 1.50592 1.21144 GeneID:79868,Genbank:XM_006724698.3,HGNC:HGNC:30881,MIM:300776 ALG13, UDP-N-acetylglucosaminyltransferase subunit GO:0003723,GO:0004577,GO:0006488,GO:0043541 RNA binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity|dolichol-linked oligosaccharide biosynthetic process|UDP-N-acetylglucosamine transferase complex hsa00510 N-Glycan biosynthesis ALG14 251.239677843119 270.360441397027 232.118914289211 0.858553540931463 -0.220019988816339 0.30669722391077 1 2.40116 2.5207 2.10079 2.37498 GeneID:199857,Genbank:NM_144988.3,HGNC:HGNC:28287,MIM:612866 ALG14, UDP-N-acetylglucosaminyltransferase subunit GO:0004577,GO:0005789,GO:0006488,GO:0016021,GO:0031965 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity|endoplasmic reticulum membrane|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|nuclear membrane hsa00510 N-Glycan biosynthesis ALG1L 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:200810,Genbank:XM_017005846.2,HGNC:HGNC:33721 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase like GO:0000030,GO:0005783,GO:0006486 mannosyltransferase activity|endoplasmic reticulum|protein glycosylation ALG2 564.298343262168 589.688788369359 538.907898154977 0.913885270983693 -0.129915033949807 0.453323861845456 1 9.95275 9.58451 9.04334 8.8473 GeneID:85365,Genbank:NM_033087.3,HGNC:HGNC:23159,MIM:607905 ALG2, alpha-1,3/1,6-mannosyltransferase GO:0000033,GO:0004378,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0006488,GO:0015629,GO:0016020,GO:0016021,GO:0033577,GO:0046982,GO:0047485,GO:0048306,GO:0048471,GO:0051592,GO:0102704 alpha-1,3-mannosyltransferase activity|GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|dolichol-linked oligosaccharide biosynthetic process|actin cytoskeleton|membrane|integral component of membrane|protein glycosylation in endoplasmic reticulum|protein heterodimerization activity|protein N-terminus binding|calcium-dependent protein binding|perinuclear region of cytoplasm|response to calcium ion|GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity hsa00510 N-Glycan biosynthesis ALG3 1713.21502071029 1773.87306057999 1652.55698084059 0.931609492000666 -0.102202755904786 0.463868713401502 1 23.8968 26.8959 24.8218 24.3199 GeneID:10195,Genbank:NM_001006941.2,HGNC:HGNC:23056,MIM:608750 ALG3, alpha-1,3- mannosyltransferase GO:0000033,GO:0005789,GO:0006486,GO:0006488,GO:0016021,GO:0052925 alpha-1,3-mannosyltransferase activity|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|integral component of membrane|dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity hsa00510 N-Glycan biosynthesis ALG5 381.701777581929 382.988585951249 380.414969212608 0.993280173788343 -0.00972737982986453 0.963337904496746 1 10.6075 12.0475 11.8591 12.1853 GeneID:29880,Genbank:NM_001142364.1,HGNC:HGNC:20266,MIM:604565 ALG5, dolichyl-phosphate beta-glucosyltransferase GO:0004576,GO:0004581,GO:0005789,GO:0006486,GO:0006487,GO:0007368,GO:0016020,GO:0016021,GO:0018279 oligosaccharyl transferase activity|dolichyl-phosphate beta-glucosyltransferase activity|endoplasmic reticulum membrane|protein glycosylation|protein N-linked glycosylation|determination of left/right symmetry|membrane|integral component of membrane|protein N-linked glycosylation via asparagine hsa00510 N-Glycan biosynthesis ALG6 211.689056431866 219.816460411373 203.561652452359 0.926052817297695 -0.11083361513791 0.659528618228803 1 3.4804 2.86444 3.41622 2.57531 GeneID:29929,Genbank:NM_013339.3,HGNC:HGNC:23157,MIM:604566 ALG6, alpha-1,3-glucosyltransferase GO:0004583,GO:0005789,GO:0006487,GO:0006488,GO:0006490,GO:0016020,GO:0016021,GO:0042281,GO:0046527 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide-lipid intermediate biosynthetic process|membrane|integral component of membrane|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity|glucosyltransferase activity hsa00510 N-Glycan biosynthesis ALG8 861.892808324816 929.474655709206 794.310960940426 0.85458054833604 -0.226711615615246 0.151619509992262 1 12.1643 11.8939 10.6566 9.24758 GeneID:79053,Genbank:NM_024079.4,HGNC:HGNC:23161,MIM:608103 ALG8, alpha-1,3-glucosyltransferase GO:0000033,GO:0004583,GO:0005789,GO:0006487,GO:0006488,GO:0006490,GO:0016021,GO:0042281 alpha-1,3-mannosyltransferase activity|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity|endoplasmic reticulum membrane|protein N-linked glycosylation|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide-lipid intermediate biosynthetic process|integral component of membrane|dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity hsa00510 N-Glycan biosynthesis ALG9 530.136196372038 536.387692416447 523.884700327629 0.976690382226163 -0.0340268047719071 0.846446799279912 1 2.12131 2.12887 2.05963 1.95022 GeneID:79796,Genbank:NM_001352409.1,HGNC:HGNC:15672,MIM:606941 ALG9, alpha-1,2-mannosyltransferase GO:0000026,GO:0000030,GO:0005783,GO:0005789,GO:0006486,GO:0006488,GO:0016020,GO:0016021,GO:0052918,GO:0052926 alpha-1,2-mannosyltransferase activity|mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|membrane|integral component of membrane|dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity|dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity hsa00510 N-Glycan biosynthesis ALK 17.9510230303863 8.76345030543964 27.138595755333 3.09679347853294 1.63077517460734 0.0179109490408589 0.546850871863472 0.0317633 0.0370138 0.102659 0.0997154 GeneID:238,Genbank:XM_024452778.1,HGNC:HGNC:427,MIM:105590 ALK receptor tyrosine kinase hsa05200,hsa05223 Pathways in cancer|Non-small cell lung cancer ALKBH1 195.515261585302 186.992502136192 204.038021034412 1.09115616243161 0.125857589877094 0.597036388375505 1 2.60125 2.81725 3.20615 2.80874 GeneID:8846,Genbank:NM_006020.2,HGNC:HGNC:17911,MIM:605345 alkB homolog 1, histone H2A dioxygenase GO:0000049,GO:0001701,GO:0001764,GO:0001890,GO:0002101,GO:0003906,GO:0005719,GO:0005739,GO:0006281,GO:0006307,GO:0006446,GO:0006448,GO:0008198,GO:0016706,GO:0031175,GO:0035552,GO:0042056,GO:0042245,GO:0043524,GO:0043734,GO:0048589,GO:0070129,GO:0070579,GO:0070989,GO:0080111,GO:0103053,GO:0140078,GO:0140080,GO:1990983,GO:1990984 tRNA binding|in utero embryonic development|neuron migration|placenta development|tRNA wobble cytosine modification|DNA-(apurinic or apyrimidinic site) lyase activity|nuclear euchromatin|mitochondrion|DNA repair|DNA dealkylation involved in DNA repair|regulation of translational initiation|regulation of translational elongation|ferrous iron binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|neuron projection development|oxidative single-stranded DNA demethylation|chemoattractant activity|RNA repair|negative regulation of neuron apoptotic process|DNA-N1-methyladenine dioxygenase activity|developmental growth|regulation of mitochondrial translation|methylcytosine dioxygenase activity|oxidative demethylation|DNA demethylation|1-ethyladenine demethylase activity|class I DNA-(apurinic or apyrimidinic site) lyase activity|class III/IV DNA-(apurinic or apyrimidinic site) lyase activity|tRNA demethylation|tRNA demethylase activity ALKBH2 379.243533810682 395.56674626787 362.920321353495 0.917469238194588 -0.12426830821011 0.681272500419449 1 9.89699 10.2604 7.59356 10.5711 GeneID:121642,Genbank:NM_001145375.1,HGNC:HGNC:32487,MIM:610602 alkB homolog 2, alpha-ketoglutarate dependent dioxygenase GO:0005634,GO:0005654,GO:0006307,GO:0008198,GO:0015630,GO:0035511,GO:0043734,GO:0051747,GO:0070989,GO:0080111,GO:0103053 nucleus|nucleoplasm|DNA dealkylation involved in DNA repair|ferrous iron binding|microtubule cytoskeleton|oxidative DNA demethylation|DNA-N1-methyladenine dioxygenase activity|cytosine C-5 DNA demethylase activity|oxidative demethylation|DNA demethylation|1-ethyladenine demethylase activity ALKBH3 678.549789333255 627.779070552232 729.320508114279 1.16174708958157 0.216296030601602 0.181234691860049 1 11.0559 10.4569 12.251 13.6859 GeneID:221120,Genbank:NM_139178.3,HGNC:HGNC:30141,MIM:610603 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase ALKBH4 609.304011043329 650.159675908854 568.448346177804 0.874321135624374 -0.193764820106797 0.236579717459895 1 12.3933 13.211 11.4559 11.5176 GeneID:54784,Genbank:NM_017621.3,HGNC:HGNC:21900,MIM:613302 alkB homolog 4, lysine demethylase GO:0003779,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0006482,GO:0016706,GO:0030496,GO:0031032,GO:0032451,GO:0036090,GO:0046872,GO:0070938 actin binding|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|protein demethylation|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|midbody|actomyosin structure organization|demethylase activity|cleavage furrow ingression|metal ion binding|contractile ring ALKBH5 4689.42381468721 4711.91491813037 4666.93271124405 0.990453518862738 -0.0138388226294287 0.898693128751229 1 79.7261 82.5307 82.6683 80.172 GeneID:54890,Genbank:NM_017758.3,HGNC:HGNC:25996,MIM:613303 alkB homolog 5, RNA demethylase GO:0001666,GO:0003723,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006307,GO:0006397,GO:0006406,GO:0007283,GO:0016607,GO:0016706,GO:0030154,GO:0035515,GO:0035553,GO:0046872 response to hypoxia|RNA binding|nucleus|nucleoplasm|Golgi apparatus|cytosol|DNA dealkylation involved in DNA repair|mRNA processing|mRNA export from nucleus|spermatogenesis|nuclear speck|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|cell differentiation|oxidative RNA demethylase activity|oxidative single-stranded RNA demethylation|metal ion binding ALKBH6 317.111330436032 293.585902387763 340.6367584843 1.16026265469107 0.214451432703531 0.494199286545661 1 2.94265 3.01234 2.49462 4.33352 GeneID:84964,Genbank:NM_001297701.1,HGNC:HGNC:28243,MIM:613304 alkB homolog 6 GO:0005634,GO:0005654,GO:0005737,GO:0005925,GO:0008198,GO:0051213 nucleus|nucleoplasm|cytoplasm|focal adhesion|ferrous iron binding|dioxygenase activity ALKBH7 523.955625510384 533.784464928352 514.126786092415 0.96317300309859 -0.0541331397100357 0.814011289111687 1 8.90125 11.0751 9.57164 11.7456 GeneID:84266,Genbank:NM_032306.3,HGNC:HGNC:21306,MIM:613305 alkB homolog 7 GO:0005759,GO:0006631,GO:0006974,GO:0010883,GO:0046872,GO:0051213,GO:1902445 mitochondrial matrix|fatty acid metabolic process|cellular response to DNA damage stimulus|regulation of lipid storage|metal ion binding|dioxygenase activity|regulation of mitochondrial membrane permeability involved in programmed necrotic cell death ALKBH8 109.956670772489 117.163248685677 102.750092859301 0.876982279101497 -0.189380403996931 0.522221793872254 1 0.857239 0.857224 0.832151 0.661795 GeneID:91801,Genbank:XM_017018555.1,HGNC:HGNC:25189,MIM:613306 alkB homolog 8, tRNA methyltransferase GO:0000049,GO:0002098,GO:0005506,GO:0005634,GO:0005654,GO:0005829,GO:0006974,GO:0008198,GO:0008270,GO:0016300,GO:0016604,GO:0016706,GO:0030488,GO:0055114 tRNA binding|tRNA wobble uridine modification|iron ion binding|nucleus|nucleoplasm|cytosol|cellular response to DNA damage stimulus|ferrous iron binding|zinc ion binding|tRNA (uracil) methyltransferase activity|nuclear body|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|tRNA methylation|oxidation-reduction process ALLC 1.26526514449636 1.07619535328461 1.45433493570811 1.35136704620532 0.434419579785585 1 1 0.00674196 0 0 0 GeneID:55821,Genbank:XM_017004495.1,HGNC:HGNC:17377,MIM:612396 allantoicase GO:0000256,GO:0004037 allantoin catabolic process|allantoicase activity hsa00230 Purine metabolism ALMS1 132.579457009799 136.698461179071 128.460452840527 0.939735910210783 -0.0896727152883091 0.838976022833845 1 0.304255 0.308957 0.379969 0.208802 GeneID:7840,Genbank:NM_015120.4,HGNC:HGNC:428,MIM:606844 ALMS1, centrosome and basal body associated protein GO:0000086,GO:0000922,GO:0005813,GO:0005829,GO:0005929,GO:0010389,GO:0016197,GO:0051393,GO:0051492,GO:0097711 G2/M transition of mitotic cell cycle|spindle pole|centrosome|cytosol|cilium|regulation of G2/M transition of mitotic cell cycle|endosomal transport|alpha-actinin binding|regulation of stress fiber assembly|ciliary basal body-plasma membrane docking ALOX12 9.45710638266414 6.80316469761019 12.1110480677181 1.78020797761554 0.832045797791057 0.414559267331366 1 0.0550568 0.00827048 0.0430858 0.0644829 GeneID:239,Genbank:XM_011523780.2,HGNC:HGNC:429,MIM:152391 arachidonate 12-lipoxygenase, 12S type hsa00590,hsa01523,hsa04726,hsa04750 Arachidonic acid metabolism|Antifolate resistance|Serotonergic synapse|Inflammatory mediator regulation of TRP channels ALOX12B 0.780196841909191 1.07619535328461 0.484198330533773 0.449916763769675 -1.15226997256519 0.981239839765731 1 0.0376055 0 0 0 GeneID:242,Genbank:NM_001139.2,HGNC:HGNC:430,MIM:603741 arachidonate 12-lipoxygenase, 12R type hsa00590,hsa04726 Arachidonic acid metabolism|Serotonergic synapse ALOX5AP 6.60157425177815 7.38928864893743 5.81385985461886 0.786795607917534 -0.345939190719417 0.859889798413054 1 0.244947 0.0648058 0 0.123008 GeneID:241,Genbank:NM_001204406.1,HGNC:HGNC:436,MIM:603700 arachidonate 5-lipoxygenase activating protein hsa04664 Fc epsilon RI signaling pathway ALOXE3 4.45092348931573 3.084507235799 5.81733974283245 1.88598673892413 0.915319531921998 0.572337004218611 1 0.032867 0.0288749 0.0407601 0.0381461 GeneID:59344,Genbank:NM_001165960.1,HGNC:HGNC:13743,MIM:607206 arachidonate lipoxygenase 3 ALPI 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:248,Genbank:NM_001631.4,HGNC:HGNC:437,MIM:171740 alkaline phosphatase, intestinal hsa00730,hsa00790 Thiamine metabolism|Folate biosynthesis ALPK1 317.416917475392 321.250414960584 313.5834199902 0.976133898624459 -0.0348490355912579 0.859833281758918 1 0.922666 1.01233 1.07876 0.84097 GeneID:80216,Genbank:XM_017008638.2,HGNC:HGNC:20917,MIM:607347 alpha kinase 1 GO:0004674,GO:0005524,GO:0005737 protein serine/threonine kinase activity|ATP binding|cytoplasm ALPK2 2596.52745166544 2468.13407766073 2724.92082567014 1.10404084216235 0.142793543216794 0.48204472775034 1 5.25418 4.91625 6.59493 4.72948 GeneID:115701,Genbank:NM_052947.3,HGNC:HGNC:20565 alpha kinase 2 GO:0004674,GO:0005524,GO:0005737 protein serine/threonine kinase activity|ATP binding|cytoplasm ALPK3 36.8080468567497 37.754098260078 35.8619954534215 0.949883512152182 -0.0741774938065673 0.890017569800809 1 0.108421 0.132083 0.118419 0.107725 GeneID:57538,Genbank:NM_020778.4,HGNC:HGNC:17574,MIM:617608 alpha kinase 3 GO:0004674,GO:0005524,GO:0005634,GO:0007507 protein serine/threonine kinase activity|ATP binding|nucleus|heart development ALPL 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0115368 0.0122718 0 GeneID:249,Genbank:XM_005245818.1,HGNC:HGNC:438,MIM:171760 alkaline phosphatase, liver/bone/kidney hsa00730,hsa00790 Thiamine metabolism|Folate biosynthesis ALPP 0.972638154859436 0.490071401957362 1.45520490776151 2.96937324224464 1.5701584476161 0.837389832160054 1 0 0.0125348 0.0267753 0 GeneID:250,Genbank:NM_001632.4,HGNC:HGNC:439,MIM:171800 alkaline phosphatase, placental hsa00730,hsa00790 Thiamine metabolism|Folate biosynthesis ALS2 709.820354697347 700.875127682178 718.765581712516 1.02552587946658 0.0363638991380921 0.814834039988432 1 1.95902 1.98458 2.29593 1.82251 GeneID:57679,Genbank:NM_020919.3,HGNC:HGNC:443,MIM:606352 ALS2, alsin Rho guanine nucleotide exchange factor hsa05014 Amyotrophic lateral sclerosis (ALS) ALS2CL 11.4431450719429 10.771762187954 12.1145279559317 1.12465609104138 0.169483906685685 0.894270370913217 1 0.0376544 0.0386311 0.0410089 0.0601889 GeneID:259173,Genbank:NM_147129.4,HGNC:HGNC:20605,MIM:612402 ALS2 C-terminal like GO:0005096,GO:0005829,GO:0007032,GO:0017112,GO:0042802 GTPase activator activity|cytosol|endosome organization|Rab guanyl-nucleotide exchange factor activity|identical protein binding ALS2CR12 2.23409679159061 1.07619535328461 3.3919982298966 3.15184247873217 1.65619543427695 0.507780098991718 1 0.0109043 0 0.0104657 0.00974809 GeneID:130540,Genbank:NM_001289993.1,HGNC:HGNC:14439 amyotrophic lateral sclerosis 2 chromosome region 12 GO:0005737,GO:0042995 cytoplasm|cell projection ALX3 2.51695833641733 4.06465003971372 0.969266633120943 0.238462505664869 -2.06816565106221 0.367453407799664 1 0.0794821 0.101901 0.0363441 0.0340987 GeneID:257,Genbank:NM_006492.2,HGNC:HGNC:449,MIM:606014 ALX homeobox 3 GO:0005634,GO:0006351,GO:0006355,GO:0007389,GO:0035115,GO:0035116,GO:0042981,GO:0043565,GO:0048701 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|pattern specification process|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|regulation of apoptotic process|sequence-specific DNA binding|embryonic cranial skeleton morphogenesis ALX4 4.21089088770724 3.57457863775636 4.84720313765811 1.35602084297704 0.439379353864019 0.847038607450236 1 0.0253492 0.0298139 0.0472067 0.0295222 GeneID:60529,Genbank:NM_021926.3,HGNC:HGNC:450,MIM:605420 ALX homeobox 4 GO:0000977,GO:0001228,GO:0001501,GO:0001942,GO:0003677,GO:0005634,GO:0005667,GO:0007517,GO:0009791,GO:0009952,GO:0035115,GO:0035116,GO:0042733,GO:0042981,GO:0046982,GO:0048565,GO:0048704,GO:0060021,GO:0071837 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|skeletal system development|hair follicle development|DNA binding|nucleus|transcription factor complex|muscle organ development|post-embryonic development|anterior/posterior pattern specification|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic digit morphogenesis|regulation of apoptotic process|protein heterodimerization activity|digestive tract development|embryonic skeletal system morphogenesis|palate development|HMG box domain binding ALYREF 3295.34420698257 3304.55910393296 3286.12931003217 0.994422918967054 -0.00806854759282618 0.943474155826866 1 149.644 147.808 148.809 151.168 GeneID:10189,Genbank:NM_005782.3,HGNC:HGNC:19071,MIM:604171 Aly/REF export factor GO:0000018,GO:0000346,GO:0000398,GO:0001649,GO:0003723,GO:0005654,GO:0005829,GO:0006369,GO:0006405,GO:0006406,GO:0016020,GO:0016032,GO:0016607,GO:0031124,GO:0031297,GO:0032786,GO:0046784,GO:0070062,GO:0071013 regulation of DNA recombination|transcription export complex|mRNA splicing, via spliceosome|osteoblast differentiation|RNA binding|nucleoplasm|cytosol|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|membrane|viral process|nuclear speck|mRNA 3'-end processing|replication fork processing|positive regulation of DNA-templated transcription, elongation|viral mRNA export from host cell nucleus|extracellular exosome|catalytic step 2 spliceosome hsa03013,hsa03015,hsa03040,hsa05168 RNA transport|mRNA surveillance pathway|Spliceosome|Herpes simplex infection AMACR 415.350430703581 418.752972638174 411.947888768988 0.983749168808729 -0.0236375832314375 0.922249878514302 1 5.08078 4.643 5.05865 4.5863 GeneID:23600,Genbank:NM_203382.2,HGNC:HGNC:451,MIM:604489 alpha-methylacyl-CoA racemase GO:0005102,GO:0005737,GO:0005739,GO:0005777,GO:0005782,GO:0005886,GO:0006699,GO:0008111,GO:0008206,GO:0033540,GO:0043231 receptor binding|cytoplasm|mitochondrion|peroxisome|peroxisomal matrix|plasma membrane|bile acid biosynthetic process|alpha-methylacyl-CoA racemase activity|bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase|intracellular membrane-bounded organelle hsa00120,hsa04146 Primary bile acid biosynthesis|Peroxisome AMBN 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.01758 GeneID:258,Genbank:NM_016519.5,HGNC:HGNC:452,MIM:601259 ameloblastin AMBP 7.77959645404001 9.74359310935436 5.81559979872566 0.596863983692256 -0.74452589440214 0.507148686307177 1 0.191076 0.113775 0.0894857 0.16608 GeneID:259,Genbank:NM_001633.3,HGNC:HGNC:453,MIM:176870 alpha-1-microglobulin/bikunin precursor GO:0004867,GO:0005576,GO:0005615,GO:0005886,GO:0006898,GO:0007155,GO:0007565,GO:0009986,GO:0016032,GO:0018298,GO:0019855,GO:0019862,GO:0020037,GO:0030163,GO:0031012,GO:0042167,GO:0042803,GO:0043231,GO:0046329,GO:0046904,GO:0050777,GO:0070062,GO:0072562 serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|plasma membrane|receptor-mediated endocytosis|cell adhesion|female pregnancy|cell surface|viral process|protein-chromophore linkage|calcium channel inhibitor activity|IgA binding|heme binding|protein catabolic process|extracellular matrix|heme catabolic process|protein homodimerization activity|intracellular membrane-bounded organelle|negative regulation of JNK cascade|calcium oxalate binding|negative regulation of immune response|extracellular exosome|blood microparticle AMBRA1 1091.09058867369 1077.7153334729 1104.46584387449 1.02482149930574 0.0353726468113532 0.835569907455795 1 5.03398 5.5853 5.61916 5.38596 GeneID:55626,Genbank:NM_001267783.1,HGNC:HGNC:25990,MIM:611359 autophagy and beclin 1 regulator 1 GO:0000045,GO:0000422,GO:0000423,GO:0005737,GO:0005739,GO:0005741,GO:0005776,GO:0005829,GO:0005930,GO:0008285,GO:0009267,GO:0010508,GO:0010667,GO:0016236,GO:0021915,GO:0030154,GO:0031625,GO:0043524,GO:0043552,GO:0045335,GO:0048471,GO:0051020,GO:0098780 autophagosome assembly|autophagy of mitochondrion|mitophagy|cytoplasm|mitochondrion|mitochondrial outer membrane|autophagosome|cytosol|axoneme|negative regulation of cell proliferation|cellular response to starvation|positive regulation of autophagy|negative regulation of cardiac muscle cell apoptotic process|macroautophagy|neural tube development|cell differentiation|ubiquitin protein ligase binding|negative regulation of neuron apoptotic process|positive regulation of phosphatidylinositol 3-kinase activity|phagocytic vesicle|perinuclear region of cytoplasm|GTPase binding|response to mitochondrial depolarisation hsa04137,hsa04140 Mitophagy - animal|Autophagy - animal AMD1 1702.31165193064 1824.08659829454 1580.53670556675 0.866481178604403 -0.206759682869486 0.246138324492882 1 24.2768 22.12 23.1463 17.4845 GeneID:262,Genbank:NM_001287215.1,HGNC:HGNC:457,MIM:180980 adenosylmethionine decarboxylase 1 GO:0004014,GO:0005829,GO:0006557,GO:0006595,GO:0006597,GO:0008295,GO:0019810 adenosylmethionine decarboxylase activity|cytosol|S-adenosylmethioninamine biosynthetic process|polyamine metabolic process|spermine biosynthetic process|spermidine biosynthetic process|putrescine binding hsa00270,hsa00330 Cysteine and methionine metabolism|Arginine and proline metabolism AMDHD1 25.1683048436862 23.2058436805199 27.1307660068524 1.16913508426446 0.22544163144294 0.724093924521441 1 0.504623 0.390532 0.230726 0.681893 GeneID:144193,Genbank:NM_152435.2,HGNC:HGNC:28577 amidohydrolase domain containing 1 GO:0005829,GO:0006548,GO:0016812,GO:0019556,GO:0019557,GO:0046872,GO:0050480 cytosol|histidine catabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides|histidine catabolic process to glutamate and formamide|histidine catabolic process to glutamate and formate|metal ion binding|imidazolonepropionase activity hsa00340 Histidine metabolism AMDHD2 563.57150636614 465.645939746918 661.497072985361 1.42060096850601 0.506501374002768 0.00298790307488518 0.204505366014363 6.77777 6.42349 9.64095 9.70352 GeneID:51005,Genbank:NM_001330449.1,HGNC:HGNC:24262 amidohydrolase domain containing 2 GO:0005634,GO:0005829,GO:0005975,GO:0006046,GO:0006048,GO:0008448,GO:0019262,GO:0046872 nucleus|cytosol|carbohydrate metabolic process|N-acetylglucosamine catabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylglucosamine-6-phosphate deacetylase activity|N-acetylneuraminate catabolic process|metal ion binding hsa00520 Amino sugar and nucleotide sugar metabolism AMELX 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0 0 GeneID:265,Genbank:NM_182680.1,HGNC:HGNC:461,MIM:300391 amelogenin, X-linked GO:0001649,GO:0001837,GO:0002062,GO:0005578,GO:0005788,GO:0007155,GO:0007165,GO:0008083,GO:0009986,GO:0030345,GO:0031214,GO:0032967,GO:0034505,GO:0042127,GO:0042475,GO:0042802,GO:0043687,GO:0044267,GO:0046848,GO:0070166,GO:0070172 osteoblast differentiation|epithelial to mesenchymal transition|chondrocyte differentiation|proteinaceous extracellular matrix|endoplasmic reticulum lumen|cell adhesion|signal transduction|growth factor activity|cell surface|structural constituent of tooth enamel|biomineral tissue development|positive regulation of collagen biosynthetic process|tooth mineralization|regulation of cell proliferation|odontogenesis of dentin-containing tooth|identical protein binding|post-translational protein modification|cellular protein metabolic process|hydroxyapatite binding|enamel mineralization|positive regulation of tooth mineralization AMER1 162.83116616752 178.325104380123 147.337227954917 0.82622818849358 -0.275387813310899 0.261403059931104 1 0.712313 0.733771 0.673056 0.551471 GeneID:139285,Genbank:NM_152424.3,HGNC:HGNC:26837,MIM:300647 APC membrane recruitment protein 1 AMFR 3215.86326859107 3161.98080293126 3269.74573425088 1.03408146286648 0.0483498427554889 0.739537994536701 1 29.2646 32.1377 32.8107 31.6947 GeneID:267,Genbank:NM_001144.5,HGNC:HGNC:463,MIM:603243 autocrine motility factor receptor hsa04141 Protein processing in endoplasmic reticulum AMH 82.8852074152966 83.8678193179002 81.902595512693 0.976567605773103 -0.0342081724983313 0.946911207164441 1 2.16256 2.08868 2.28076 1.9974 GeneID:268,Genbank:NM_000479.4,HGNC:HGNC:464,MIM:600957 anti-Mullerian hormone hsa04024,hsa04060,hsa04350,hsa04390 cAMP signaling pathway|Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway AMHR2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:269,Genbank:XM_011538184.2,HGNC:HGNC:465,MIM:600956 anti-Mullerian hormone receptor type 2 hsa04060,hsa04350 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway AMIGO1 176.68221307262 172.607943690905 180.756482454335 1.04720836474376 0.0665485261984448 0.812149700094497 1 1.15437 1.43715 1.28722 1.41392 GeneID:57463,Genbank:NM_020703.3,HGNC:HGNC:20824,MIM:615689 adhesion molecule with Ig like domain 1 GO:0007156,GO:0007157,GO:0007409,GO:0007413,GO:0008076,GO:0015459,GO:0030424,GO:0030425,GO:0032809,GO:0042552,GO:0043204,GO:0050772,GO:0051965,GO:1901381 homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|axonogenesis|axonal fasciculation|voltage-gated potassium channel complex|potassium channel regulator activity|axon|dendrite|neuronal cell body membrane|myelination|perikaryon|positive regulation of axonogenesis|positive regulation of synapse assembly|positive regulation of potassium ion transmembrane transport AMIGO2 3913.65031360327 3796.93337172005 4030.36725548649 1.06147958389396 0.0860766232468781 0.511728216600159 1 35.1531 33.6502 40.0008 33.9864 GeneID:347902,Genbank:NM_181847.4,HGNC:HGNC:24073,MIM:615690 adhesion molecule with Ig like domain 2 GO:0005634,GO:0005886,GO:0007156,GO:0007157,GO:0016021,GO:0043066,GO:0043069,GO:0051965 nucleus|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|integral component of membrane|negative regulation of apoptotic process|negative regulation of programmed cell death|positive regulation of synapse assembly AMIGO3 326.03899350696 322.05705297512 330.0209340388 1.02472816847236 0.0352412541130461 0.846832275408757 1 5.44442 4.80673 5.54994 5.56947 GeneID:386724,Genbank:NM_198722.2,HGNC:HGNC:24075,MIM:615691 adhesion molecule with Ig like domain 3 GO:0007157,GO:0016021,GO:0051965 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|integral component of membrane|positive regulation of synapse assembly AMMECR1 476.122727563591 544.141573952648 408.103881174533 0.749995774463737 -0.415045627515357 0.0197543345784824 0.574202218891059 4.58656 4.30404 3.82903 2.8075 GeneID:9949,Genbank:NM_001171689.1,HGNC:HGNC:467,MIM:300195 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 GO:0005634 nucleus AMMECR1L 1086.2231915274 1130.49693205853 1041.94945099627 0.921673842227039 -0.117671788320775 0.436067647729009 1 6.9049 7.01065 6.42659 6.37641 GeneID:83607,Genbank:XM_011511952.3,HGNC:HGNC:28658 AMMECR1 like AMN 36.1785635158973 38.4362747607751 33.9208522710194 0.882521849012179 -0.180296098575704 0.723710604642202 1 0.309848 0.173349 0.241804 0.236627 GeneID:81693,Genbank:XM_011537202.3,HGNC:HGNC:14604,MIM:605799 amnion associated transmembrane protein GO:0005102,GO:0005615,GO:0005886,GO:0005905,GO:0006898,GO:0007275,GO:0007588,GO:0009235,GO:0010008,GO:0015889,GO:0016021,GO:0016324,GO:0030139,GO:0031526,GO:0034384,GO:0043001,GO:0043234,GO:0070062 receptor binding|extracellular space|plasma membrane|clathrin-coated pit|receptor-mediated endocytosis|multicellular organism development|excretion|cobalamin metabolic process|endosome membrane|cobalamin transport|integral component of membrane|apical plasma membrane|endocytic vesicle|brush border membrane|high-density lipoprotein particle clearance|Golgi to plasma membrane protein transport|protein complex|extracellular exosome AMN1 123.403774555143 125.648349998115 121.159199112171 0.964272106350692 -0.0524877792529931 0.843764938587542 1 0.564345 0.771311 0.719338 0.580665 GeneID:196394,Genbank:NM_001278411.1,HGNC:HGNC:27281 antagonist of mitotic exit network 1 homolog AMOT 2794.48651590652 2813.10002501401 2775.87300679902 0.986766550110565 -0.0192192835942117 0.94077977920197 1 13.3003 12.5729 15.3674 10.7286 GeneID:154796,Genbank:XM_011530875.2,HGNC:HGNC:17810,MIM:300410 angiomotin hsa04390,hsa04530 Hippo signaling pathway|Tight junction AMOTL1 1033.90307225266 919.107738029803 1148.69840647553 1.24979734033996 0.321694175055185 0.0961064719790351 1 2.91613 3.19279 4.55145 3.38422 GeneID:154810,Genbank:XM_006718772.3,HGNC:HGNC:17811,MIM:614657 angiomotin like 1 GO:0003365,GO:0005829,GO:0005923,GO:0016055,GO:0016324,GO:0030027,GO:0031410,GO:0035329,GO:0042802,GO:0043536 establishment of cell polarity involved in ameboidal cell migration|cytosol|bicellular tight junction|Wnt signaling pathway|apical plasma membrane|lamellipodium|cytoplasmic vesicle|hippo signaling|identical protein binding|positive regulation of blood vessel endothelial cell migration hsa04530 Tight junction AMOTL2 2752.58290151927 2815.89942560426 2689.26637743427 0.955029271635716 -0.0663831424756207 0.619866435751547 1 20.142 20.6196 20.698 19.122 GeneID:51421,Genbank:NM_001278683.1,HGNC:HGNC:17812,MIM:614658 angiomotin like 2 GO:0005829,GO:0005923,GO:0016055,GO:0016324,GO:0035329,GO:0042802,GO:0055037 cytosol|bicellular tight junction|Wnt signaling pathway|apical plasma membrane|hippo signaling|identical protein binding|recycling endosome hsa04530 Tight junction AMPD1 228.636073931562 197.034061548764 260.238086314359 1.32077715024898 0.4013870666209 0.0679588134227187 0.916876212609253 2.4581 2.79596 3.36817 3.25037 GeneID:270,Genbank:NM_001172626.1,HGNC:HGNC:468,MIM:102770 adenosine monophosphate deaminase 1 GO:0003876,GO:0005829,GO:0010033,GO:0032036,GO:0032264,GO:0043101,GO:0046872 AMP deaminase activity|cytosol|response to organic substance|myosin heavy chain binding|IMP salvage|purine-containing compound salvage|metal ion binding hsa00230 Purine metabolism AMPD2 1805.59823530733 1597.03778771596 2014.15868289871 1.26118411122839 0.334778899748225 0.0196985237769191 0.574202218891059 12.6184 12.8117 17.5682 15.8473 GeneID:271,Genbank:NM_001257360.1,HGNC:HGNC:469,MIM:102771 adenosine monophosphate deaminase 2 GO:0003876,GO:0005829,GO:0006188,GO:0032264,GO:0043101,GO:0046872,GO:0052652,GO:0097009 AMP deaminase activity|cytosol|IMP biosynthetic process|IMP salvage|purine-containing compound salvage|metal ion binding|cyclic purine nucleotide metabolic process|energy homeostasis hsa00230 Purine metabolism AMPD3 11.6717806511095 12.1939501191412 11.1496111830777 0.91435597768896 -0.129172149229423 0.916819810270615 1 0.0737036 0.103807 0.115669 0.0575674 GeneID:272,Genbank:NM_001172431.1,HGNC:HGNC:470,MIM:102772 adenosine monophosphate deaminase 3 GO:0003876,GO:0005576,GO:0005829,GO:0006196,GO:0032264,GO:0034101,GO:0034774,GO:0043101,GO:0043312,GO:0046031,GO:0046034,GO:0046039,GO:0046872,GO:0097009,GO:1904813 AMP deaminase activity|extracellular region|cytosol|AMP catabolic process|IMP salvage|erythrocyte homeostasis|secretory granule lumen|purine-containing compound salvage|neutrophil degranulation|ADP metabolic process|ATP metabolic process|GTP metabolic process|metal ion binding|energy homeostasis|ficolin-1-rich granule lumen hsa00230 Purine metabolism AMPH 714.899749231835 733.345318726057 696.454179737613 0.949694723554614 -0.0744642568040216 0.63227108170269 1 3.03326 3.74734 3.50344 2.91813 GeneID:273,Genbank:XM_006715690.4,HGNC:HGNC:471,MIM:600418 amphiphysin GO:0005543,GO:0005829,GO:0006897,GO:0007268,GO:0008021,GO:0015629,GO:0030054,GO:0030672,GO:0031256,GO:0061024 phospholipid binding|cytosol|endocytosis|chemical synaptic transmission|synaptic vesicle|actin cytoskeleton|cell junction|synaptic vesicle membrane|leading edge membrane|membrane organization hsa04144,hsa04666 Endocytosis|Fc gamma R-mediated phagocytosis AMT 15.1395164343236 13.3181717471107 16.9608611215364 1.273512719583 0.348813369025276 0.668164545443578 1 0.180172 0.179579 0.25356 0.317386 GeneID:275,Genbank:NM_001164711.1,HGNC:HGNC:473,MIM:238310 aminomethyltransferase GO:0004047,GO:0005654,GO:0005739,GO:0005759,GO:0006546,GO:0008483,GO:0019464 aminomethyltransferase activity|nucleoplasm|mitochondrion|mitochondrial matrix|glycine catabolic process|transaminase activity|glycine decarboxylation via glycine cleavage system hsa00260,hsa00630,hsa00670 Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism|One carbon pool by folate AMY2B 7.7127543734793 6.21704074628294 9.20846800067565 1.48116577910178 0.566733122938083 0.621790712092161 1 0.205122 0.0721064 0.217174 0.201357 GeneID:280,Genbank:NM_020978.4,HGNC:HGNC:478,MIM:104660 amylase, alpha 2B (pancreatic) GO:0004556,GO:0005975,GO:0007586,GO:0046872,GO:0070062,GO:0103025 alpha-amylase activity|carbohydrate metabolic process|digestion|metal ion binding|extracellular exosome|alpha-amylase activity (releasing maltohexaose) hsa00500,hsa04972,hsa04973 Starch and sucrose metabolism|Pancreatic secretion|Carbohydrate digestion and absorption AMZ1 2.77426103189131 2.64246210852658 2.90605995525603 1.09975463635936 0.137181683392666 1 1 0.0191326 0.00422352 0.00446604 0.0208883 GeneID:155185,Genbank:XM_011515151.3,HGNC:HGNC:22231,MIM:615168 archaelysin family metallopeptidase 1 GO:0006508,GO:0008233,GO:0008237,GO:0008270 proteolysis|peptidase activity|metallopeptidase activity|zinc ion binding AMZ2 1315.29266429742 1248.41980948491 1382.16551910993 1.1071319988748 0.146827239074553 0.323026465448062 1 14.3567 15.0165 17.2263 16.1024 GeneID:51321,Genbank:XM_005257432.4,HGNC:HGNC:28041,MIM:615169 archaelysin family metallopeptidase 2 GO:0006508,GO:0008233,GO:0008237,GO:0008270 proteolysis|peptidase activity|metallopeptidase activity|zinc ion binding ANAPC1 888.060922208672 936.670822258549 839.451022158795 0.896207079595654 -0.158095971769852 0.420844746476158 1 3.66518 3.11685 3.39549 2.67071 GeneID:64682,Genbank:XM_017004710.2,HGNC:HGNC:19988,MIM:608473 anaphase promoting complex subunit 1 GO:0005654,GO:0005680,GO:0005829,GO:0031145,GO:0042787,GO:0043161,GO:0051301,GO:0051436,GO:0051437,GO:0051439,GO:0070979 nucleoplasm|anaphase-promoting complex|cytosol|anaphase-promoting complex-dependent catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination hsa04110,hsa04114,hsa04120,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC10 242.832502475301 268.073780521511 217.591224429091 0.811684096840014 -0.301009747524853 0.157864630400417 1 1.15325 1.32034 1.10507 1.09983 GeneID:10393,Genbank:XM_011531532.2,HGNC:HGNC:24077,MIM:613745 anaphase promoting complex subunit 10 GO:0005680,GO:0005737,GO:0007049,GO:0031145,GO:0051301,GO:0070979,GO:1904668 anaphase-promoting complex|cytoplasm|cell cycle|anaphase-promoting complex-dependent catabolic process|cell division|protein K11-linked ubiquitination|positive regulation of ubiquitin protein ligase activity hsa04110,hsa04114,hsa04120,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC11 2014.92939013102 1970.39946741829 2059.45931284375 1.04519887814533 0.0637774812678514 0.790770157917134 1 15.7152 18.9857 16.9934 21.773 GeneID:51529,Genbank:NM_001289414.1,HGNC:HGNC:14452,MIM:614534 anaphase promoting complex subunit 11 GO:0000278,GO:0005654,GO:0005680,GO:0005730,GO:0005829,GO:0016567,GO:0031145,GO:0034450,GO:0042787,GO:0043161,GO:0045842,GO:0046872,GO:0051301,GO:0051436,GO:0051437,GO:0051439,GO:0061630,GO:0070979,GO:0097602 mitotic cell cycle|nucleoplasm|anaphase-promoting complex|nucleolus|cytosol|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|ubiquitin-ubiquitin ligase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of mitotic metaphase/anaphase transition|metal ion binding|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|ubiquitin protein ligase activity|protein K11-linked ubiquitination|cullin family protein binding hsa04110,hsa04114,hsa04120,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC13 595.137118679057 597.068268363189 593.205968994925 0.993531226539887 -0.00936278300751715 0.978807220933421 1 13.3982 12.2207 14.0582 12.4368 GeneID:25847,Genbank:NM_001242374.1,HGNC:HGNC:24540,MIM:614484 anaphase promoting complex subunit 13 GO:0005680,GO:0007049,GO:0051301,GO:0070979 anaphase-promoting complex|cell cycle|cell division|protein K11-linked ubiquitination hsa04110,hsa04114,hsa04120,hsa04914 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation ANAPC15 710.621798433077 713.742462647763 707.50113421839 0.991255489541397 -0.0126711444493391 0.934580902960653 1 4.46039 4.67475 4.65784 5.33325 GeneID:25906,Genbank:NM_001330321.1,HGNC:HGNC:24531,MIM:614717 anaphase promoting complex subunit 15 GO:0005680,GO:0007049,GO:0051301,GO:0090266 anaphase-promoting complex|cell cycle|cell division|regulation of mitotic cell cycle spindle assembly checkpoint ANAPC16 2324.51729389678 2257.54272999229 2391.49185780127 1.05933403874461 0.0831575846572379 0.53827185005027 1 24.7454 23.3497 24.3039 26.5949 GeneID:119504,Genbank:NM_001242546.1,HGNC:HGNC:26976,MIM:613427 anaphase promoting complex subunit 16 GO:0000776,GO:0000777,GO:0005654,GO:0005680,GO:0005829,GO:0016567,GO:0031145,GO:0042787,GO:0043161,GO:0051301,GO:0051436,GO:0051437,GO:0051439 kinetochore|condensed chromosome kinetochore|nucleoplasm|anaphase-promoting complex|cytosol|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle ANAPC2 853.924034907238 853.007967697061 854.840102117414 1.00214785147353 0.00309537165884722 0.985947111774801 1 12.3847 13.8867 13.4634 13.9306 GeneID:29882,Genbank:NM_013366.3,HGNC:HGNC:19989,MIM:606946 anaphase promoting complex subunit 2 GO:0005654,GO:0005680,GO:0005829,GO:0031145,GO:0031625,GO:0031915,GO:0042787,GO:0043161,GO:0045773,GO:0050775,GO:0051301,GO:0051436,GO:0051437,GO:0051439,GO:0070979,GO:0090129 nucleoplasm|anaphase-promoting complex|cytosol|anaphase-promoting complex-dependent catabolic process|ubiquitin protein ligase binding|positive regulation of synaptic plasticity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of axon extension|positive regulation of dendrite morphogenesis|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|positive regulation of synapse maturation hsa04110,hsa04114,hsa04120,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC4 228.043769193323 238.967462707287 217.120075679358 0.908575892381257 -0.138321068607189 0.549377706593438 1 2.8224 2.40862 2.56436 2.45288 GeneID:29945,Genbank:NM_001286756.1,HGNC:HGNC:19990,MIM:606947 anaphase promoting complex subunit 4 GO:0005680,GO:0007049,GO:0030071,GO:0031145,GO:0051301,GO:0070979 anaphase-promoting complex|cell cycle|regulation of mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent catabolic process|cell division|protein K11-linked ubiquitination hsa04110,hsa04114,hsa04120,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC5 2627.55115913912 2742.37992365641 2512.72239462182 0.916256122263183 -0.126177161772728 0.355451252073668 1 38.8153 39.0019 36.2427 36.3994 GeneID:51433,Genbank:NM_001137559.1,HGNC:HGNC:15713,MIM:606948 anaphase promoting complex subunit 5 GO:0005634,GO:0005654,GO:0005680,GO:0005829,GO:0019903,GO:0031145,GO:0042787,GO:0043161,GO:0051301,GO:0051436,GO:0051437,GO:0051439,GO:0070979 nucleus|nucleoplasm|anaphase-promoting complex|cytosol|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination hsa04110,hsa04114,hsa04120,hsa04657,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|IL-17 signaling pathway|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANAPC7 1290.57896098263 1261.9869042597 1319.17101770555 1.04531276295564 0.0639346686740453 0.659782517179242 1 8.39318 8.33879 9.01061 8.50615 GeneID:51434,Genbank:NM_016238.2,HGNC:HGNC:17380,MIM:606949 anaphase promoting complex subunit 7 GO:0005634,GO:0005654,GO:0005680,GO:0005829,GO:0019903,GO:0031145,GO:0042787,GO:0043161,GO:0051301,GO:0051436,GO:0051437,GO:0051439,GO:0070979 nucleus|nucleoplasm|anaphase-promoting complex|cytosol|protein phosphatase binding|anaphase-promoting complex-dependent catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination hsa04110,hsa04114,hsa04120,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection ANG 16.8414969871706 13.8082431490681 19.874750825273 1.43933957497079 0.525406998841128 0.472029629003913 1 0.948396 0.911981 1.02773 0.788274 GeneID:283,Genbank:NM_001145.4,HGNC:HGNC:483,MIM:105850 angiogenin ANGEL1 378.149346033076 363.271077014224 393.027615051928 1.08191276410519 0.113584177661399 0.561519373610187 1 3.2155 3.62296 3.81524 3.87299 GeneID:23357,Genbank:XM_017021115.2,HGNC:HGNC:19961 angel homolog 1 GO:0005634,GO:0005783,GO:0005801,GO:0005829,GO:0008190,GO:0019904,GO:0048471 nucleus|endoplasmic reticulum|cis-Golgi network|cytosol|eukaryotic initiation factor 4E binding|protein domain specific binding|perinuclear region of cytoplasm ANGEL2 437.339820515644 497.143762640281 377.535878391008 0.759409866445778 -0.397049351948364 0.0288512973107832 0.674846840672015 3.90523 3.75175 3.09155 2.73576 GeneID:90806,Genbank:NM_001300758.1,HGNC:HGNC:30534 angel homolog 2 GO:0003730,GO:0005737,GO:0015030,GO:0045930,GO:0070935 mRNA 3'-UTR binding|cytoplasm|Cajal body|negative regulation of mitotic cell cycle|3'-UTR-mediated mRNA stabilization ANGPT1 52.4595476510759 47.7280140877491 57.1910812144026 1.19827070762373 0.260953871755689 0.495827942386859 1 0.429976 0.279418 0.467548 0.41884 GeneID:284,Genbank:NM_001199859.2,HGNC:HGNC:484,MIM:601667 angiopoietin 1 GO:0001525,GO:0005576,GO:0030154,GO:0030971,GO:0048014 angiogenesis|extracellular region|cell differentiation|receptor tyrosine kinase binding|Tie signaling pathway hsa04010,hsa04014,hsa04015,hsa04066,hsa04151,hsa05323 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Rheumatoid arthritis ANGPT2 6.07565770400972 8.27337890348227 3.87793650453717 0.468724634732363 -1.09318747444156 0.396668428373527 1 0.048268 0.0332316 0.0265251 0.00617496 GeneID:285,Genbank:NM_001118888.1,HGNC:HGNC:485,MIM:601922 angiopoietin 2 hsa04010,hsa04014,hsa04015,hsa04066,hsa04151,hsa05167 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Kaposi sarcoma-associated herpesvirus infection ANGPT4 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00811158 0 0 GeneID:51378,Genbank:NM_001322809.1,HGNC:HGNC:487,MIM:603705 angiopoietin 4 GO:0001525,GO:0005576,GO:0005615,GO:0007219,GO:0010595,GO:0016525,GO:0030297,GO:0030971,GO:0043066,GO:0043536,GO:0043537,GO:0045766,GO:0050731,GO:0050900,GO:0071456 angiogenesis|extracellular region|extracellular space|Notch signaling pathway|positive regulation of endothelial cell migration|negative regulation of angiogenesis|transmembrane receptor protein tyrosine kinase activator activity|receptor tyrosine kinase binding|negative regulation of apoptotic process|positive regulation of blood vessel endothelial cell migration|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|cellular response to hypoxia hsa04010,hsa04014,hsa04015,hsa04066,hsa04151 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway ANGPTL2 1.75033344708353 1.07619535328461 2.42447154088245 2.25281732864097 1.17173033632162 0.729379640727937 1 0.0094844 0 0.0179421 0.00418328 GeneID:23452,Genbank:NM_012098.2,HGNC:HGNC:490,MIM:605001 angiopoietin like 2 GO:0005102,GO:0005615,GO:0007275,GO:0070062 receptor binding|extracellular space|multicellular organism development|extracellular exosome ANGPTL4 96.2631876121912 93.6594387019395 98.866936522443 1.05560035264652 0.0780637377409226 0.800279298633387 1 2.3004 1.66611 2.3217 2.12446 GeneID:51129,Genbank:NM_139314.2,HGNC:HGNC:16039,MIM:605910 angiopoietin like 4 GO:0001525,GO:0001666,GO:0004857,GO:0005576,GO:0005578,GO:0005615,GO:0019216,GO:0030154,GO:0042802,GO:0043066,GO:0045766,GO:0051005,GO:0051260,GO:0070328,GO:0072562,GO:2000352 angiogenesis|response to hypoxia|enzyme inhibitor activity|extracellular region|proteinaceous extracellular matrix|extracellular space|regulation of lipid metabolic process|cell differentiation|identical protein binding|negative regulation of apoptotic process|positive regulation of angiogenesis|negative regulation of lipoprotein lipase activity|protein homooligomerization|triglyceride homeostasis|blood microparticle|negative regulation of endothelial cell apoptotic process hsa03320,hsa04979 PPAR signaling pathway|Cholesterol metabolism ANGPTL6 15.5662385501286 15.6146412777348 15.5178358225225 0.993800340751321 -0.0089720583322464 1 1 0.249462 0.107924 0.402959 0.0718108 GeneID:83854,Genbank:NM_031917.2,HGNC:HGNC:23140,MIM:609336 angiopoietin like 6 GO:0001525,GO:0030141,GO:0030154,GO:0070062 angiogenesis|secretory granule|cell differentiation|extracellular exosome ANGPTL8 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0 0 0 0 GeneID:55908,Genbank:NM_018687.6,HGNC:HGNC:24933,MIM:616223 angiopoietin like 8 GO:0005179,GO:0005576,GO:0010954,GO:0019216,GO:0044255,GO:0045444,GO:0048469,GO:0050746,GO:0051004,GO:0070328 hormone activity|extracellular region|positive regulation of protein processing|regulation of lipid metabolic process|cellular lipid metabolic process|fat cell differentiation|cell maturation|regulation of lipoprotein metabolic process|regulation of lipoprotein lipase activity|triglyceride homeostasis hsa04979 Cholesterol metabolism ANK1 465.492959017224 430.323598187266 500.662319847183 1.16345541345215 0.218415924087483 0.266367774230914 1 1.06565 1.33542 1.53867 1.18965 GeneID:286,Genbank:NM_001142446.1,HGNC:HGNC:492,MIM:612641 ankyrin 1 GO:0005886,GO:0006779,GO:0006888,GO:0007165,GO:0008093,GO:0014731,GO:0015672,GO:0016020,GO:0016529,GO:0019899,GO:0030507,GO:0030863,GO:0048821,GO:0051117,GO:0055072,GO:0072659 plasma membrane|porphyrin-containing compound biosynthetic process|ER to Golgi vesicle-mediated transport|signal transduction|cytoskeletal adaptor activity|spectrin-associated cytoskeleton|monovalent inorganic cation transport|membrane|sarcoplasmic reticulum|enzyme binding|spectrin binding|cortical cytoskeleton|erythrocyte development|ATPase binding|iron ion homeostasis|protein localization to plasma membrane hsa05205 Proteoglycans in cancer ANK2 332.726827802065 322.777447095394 342.676208508736 1.06164854946467 0.0863062521492845 0.714986057178037 1 0.451588 0.365472 0.516579 0.358035 GeneID:287,Genbank:NM_001354269.1,HGNC:HGNC:493,MIM:106410 ankyrin 2 GO:0002027,GO:0005622,GO:0005737,GO:0005739,GO:0005764,GO:0005769,GO:0005856,GO:0005886,GO:0005887,GO:0006874,GO:0006897,GO:0008104,GO:0010628,GO:0010881,GO:0010882,GO:0014069,GO:0014704,GO:0015031,GO:0015459,GO:0016324,GO:0030018,GO:0030315,GO:0030507,GO:0030674,GO:0031430,GO:0031647,GO:0031672,GO:0033292,GO:0034394,GO:0034613,GO:0036309,GO:0036371,GO:0042383,GO:0043034,GO:0043268,GO:0044325,GO:0045211,GO:0048471,GO:0050821,GO:0051117,GO:0051924,GO:0051928,GO:0055037,GO:0055117,GO:0060048,GO:0070972,GO:0072659,GO:0086004,GO:0086014,GO:0086015,GO:0086036,GO:0086066,GO:0086070,GO:0086091,GO:0098904,GO:0098907,GO:0098910,GO:1901018,GO:1901019,GO:1901021,GO:2001257,GO:2001259 regulation of heart rate|intracellular|cytoplasm|mitochondrion|lysosome|early endosome|cytoskeleton|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|endocytosis|protein localization|positive regulation of gene expression|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of cardiac muscle contraction by calcium ion signaling|postsynaptic density|intercalated disc|protein transport|potassium channel regulator activity|apical plasma membrane|Z disc|T-tubule|spectrin binding|protein binding, bridging|M band|regulation of protein stability|A band|T-tubule organization|protein localization to cell surface|cellular protein localization|protein localization to M-band|protein localization to T-tubule|sarcolemma|costamere|positive regulation of potassium ion transport|ion channel binding|postsynaptic membrane|perinuclear region of cytoplasm|protein stabilization|ATPase binding|regulation of calcium ion transport|positive regulation of calcium ion transport|recycling endosome|regulation of cardiac muscle contraction|cardiac muscle contraction|protein localization to endoplasmic reticulum|protein localization to plasma membrane|regulation of cardiac muscle cell contraction|atrial cardiac muscle cell action potential|SA node cell action potential|regulation of cardiac muscle cell membrane potential|atrial cardiac muscle cell to AV node cell communication|SA node cell to atrial cardiac muscle cell communication|regulation of heart rate by cardiac conduction|regulation of AV node cell action potential|regulation of SA node cell action potential|regulation of atrial cardiac muscle cell action potential|positive regulation of potassium ion transmembrane transporter activity|regulation of calcium ion transmembrane transporter activity|positive regulation of calcium ion transmembrane transporter activity|regulation of cation channel activity|positive regulation of cation channel activity hsa05205 Proteoglycans in cancer ANK3 52.748849640808 56.5492993229817 48.9483999586343 0.86558808941319 -0.208247447227655 0.619239251221988 1 0.0830767 0.0721166 0.0694018 0.0662349 GeneID:288,Genbank:NM_001204403.1,HGNC:HGNC:494,MIM:600465 ankyrin 3 GO:0000281,GO:0005200,GO:0005764,GO:0005886,GO:0007009,GO:0007165,GO:0007409,GO:0007411,GO:0007528,GO:0008092,GO:0009986,GO:0010628,GO:0010650,GO:0010765,GO:0010960,GO:0014704,GO:0014731,GO:0016020,GO:0016323,GO:0016328,GO:0016529,GO:0019228,GO:0030018,GO:0030315,GO:0030424,GO:0030425,GO:0030507,GO:0030674,GO:0031594,GO:0033268,GO:0033270,GO:0034112,GO:0042383,GO:0043001,GO:0043034,GO:0043194,GO:0043266,GO:0044325,GO:0045184,GO:0045202,GO:0045211,GO:0045296,GO:0045760,GO:0045838,GO:0050808,GO:0071286,GO:0071709,GO:0072659,GO:0072660,GO:0090314,GO:0099612,GO:1900827,GO:1902260,GO:2000651,GO:2001259 mitotic cytokinesis|structural constituent of cytoskeleton|lysosome|plasma membrane|plasma membrane organization|signal transduction|axonogenesis|axon guidance|neuromuscular junction development|cytoskeletal protein binding|cell surface|positive regulation of gene expression|positive regulation of cell communication by electrical coupling|positive regulation of sodium ion transport|magnesium ion homeostasis|intercalated disc|spectrin-associated cytoskeleton|membrane|basolateral plasma membrane|lateral plasma membrane|sarcoplasmic reticulum|neuronal action potential|Z disc|T-tubule|axon|dendrite|spectrin binding|protein binding, bridging|neuromuscular junction|node of Ranvier|paranode region of axon|positive regulation of homotypic cell-cell adhesion|sarcolemma|Golgi to plasma membrane protein transport|costamere|axon initial segment|regulation of potassium ion transport|ion channel binding|establishment of protein localization|synapse|postsynaptic membrane|cadherin binding|positive regulation of action potential|positive regulation of membrane potential|synapse organization|cellular response to magnesium ion|membrane assembly|protein localization to plasma membrane|maintenance of protein location in plasma membrane|positive regulation of protein targeting to membrane|protein localization to axon|positive regulation of membrane depolarization during cardiac muscle cell action potential|negative regulation of delayed rectifier potassium channel activity|positive regulation of sodium ion transmembrane transporter activity|positive regulation of cation channel activity hsa05205 Proteoglycans in cancer ANKAR 22.0266576073689 18.3629645907392 25.6903506239987 1.39903066833527 0.484427588357025 0.446420990221987 1 0.0334885 0.0716835 0.123202 0.0481225 GeneID:150709,Genbank:XM_011510676.2,HGNC:HGNC:26350,MIM:609803 ankyrin and armadillo repeat containing GO:0005634,GO:0005737,GO:0016021 nucleus|cytoplasm|integral component of membrane ANKDD1A 18.7448512528994 21.4954981012231 15.9942044045757 0.744072285706446 -0.426485310698661 0.53272949820392 1 0.23007 0.271776 0.156046 0.130502 GeneID:348094,Genbank:NM_182703.5,HGNC:HGNC:28002 ankyrin repeat and death domain containing 1A GO:0007165 signal transduction ANKDD1B 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.0156653 0 0.0298302 0 GeneID:728780,Genbank:XM_017009814.1,HGNC:HGNC:32525 ankyrin repeat and death domain containing 1B GO:0007165 signal transduction ANKEF1 118.610097622208 117.50924126358 119.710953980837 1.0187365069639 0.0267809511570301 0.938447743490085 1 0.878953 0.917343 0.985344 0.793239 GeneID:63926,Genbank:NM_022096.5,HGNC:HGNC:15803 ankyrin repeat and EF-hand domain containing 1 GO:0005509 calcium ion binding ANKFN1 6.53290636148923 7.73528122683997 5.33053149613849 0.689119288597103 -0.537174355540729 0.695533923340114 1 0.00167892 0.00481132 0 0.00602101 GeneID:162282,Genbank:XM_017024263.1,HGNC:HGNC:26766 ankyrin repeat and fibronectin type III domain containing 1 ANKFY1 3091.26492857293 3147.98619533514 3034.54366181073 0.963963459022624 -0.0529496356582855 0.707670482235632 1 13.2819 12.7707 14.1137 10.9082 GeneID:51479,Genbank:NM_001330063.1,HGNC:HGNC:20763,MIM:607927 ankyrin repeat and FYVE domain containing 1 GO:0005765,GO:0005768,GO:0005769,GO:0005829,GO:0006897,GO:0010008,GO:0016020,GO:0017137,GO:0032439,GO:0034058,GO:0042147,GO:0043231,GO:0044354,GO:0046872,GO:0048549,GO:0070062,GO:0090160,GO:1901981 lysosomal membrane|endosome|early endosome|cytosol|endocytosis|endosome membrane|membrane|Rab GTPase binding|endosome localization|endosomal vesicle fusion|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|macropinosome|metal ion binding|positive regulation of pinocytosis|extracellular exosome|Golgi to lysosome transport|phosphatidylinositol phosphate binding ANKH 973.65693848804 906.365881578911 1040.94799539717 1.14848541472436 0.199732535219587 0.196742767800612 1 3.80002 4.29287 4.58739 4.7169 GeneID:56172,Genbank:NM_054027.5,HGNC:HGNC:15492,MIM:605145 ANKH inorganic pyrophosphate transport regulator GO:0001501,GO:0005315,GO:0005886,GO:0005887,GO:0007626,GO:0015114,GO:0016021,GO:0019867,GO:0030500,GO:0030504,GO:0055085 skeletal system development|inorganic phosphate transmembrane transporter activity|plasma membrane|integral component of plasma membrane|locomotory behavior|phosphate ion transmembrane transporter activity|integral component of membrane|outer membrane|regulation of bone mineralization|inorganic diphosphate transmembrane transporter activity|transmembrane transport ANKHD1 22.7210023307451 16.8447241101821 28.5972805513081 1.69769955056859 0.763581161330369 0.209699617913013 1 2.49967 2.02769 2.75837 2.73309 GeneID:54882,Genbank:NM_017747.2,HGNC:HGNC:24714,MIM:610500 ankyrin repeat and KH domain containing 1 GO:0003723,GO:0005737,GO:0045087 RNA binding|cytoplasm|innate immune response ANKIB1 932.966129862504 965.785931727027 900.146327997982 0.932035038435829 -0.101543903068506 0.794139331634221 1 5.77696 4.86043 6.50916 3.81445 GeneID:54467,Genbank:XM_005250458.4,HGNC:HGNC:22215 ankyrin repeat and IBR domain containing 1 GO:0000151,GO:0000209,GO:0005737,GO:0031624,GO:0032436,GO:0042787,GO:0046872,GO:0061630 ubiquitin ligase complex|protein polyubiquitination|cytoplasm|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity ANKK1 1.6989356506601 0.490071401957362 2.90779989936283 5.93342090101356 2.5688641273566 0.446225520480844 1 0 0.00564221 0.00587912 0.0109654 GeneID:255239,Genbank:XM_011542736.2,HGNC:HGNC:21027,MIM:608774 ankyrin repeat and kinase domain containing 1 GO:0004674,GO:0005524 protein serine/threonine kinase activity|ATP binding ANKLE1 16.7962988817223 14.6923334036129 18.9002643598317 1.28640317644739 0.363342874004504 0.648100439636452 1 0.0998966 0.199603 0.186081 0.198267 GeneID:126549,Genbank:NM_152363.5,HGNC:HGNC:26812 ankyrin repeat and LEM domain containing 1 GO:0004519,GO:0005639,GO:0005737,GO:0006281,GO:0006611,GO:0006998,GO:0031490,GO:0070197,GO:0090305,GO:2001022 endonuclease activity|integral component of nuclear inner membrane|cytoplasm|DNA repair|protein export from nucleus|nuclear envelope organization|chromatin DNA binding|meiotic attachment of telomere to nuclear envelope|nucleic acid phosphodiester bond hydrolysis|positive regulation of response to DNA damage stimulus ANKLE2 2483.83371745496 2675.3666371038 2292.30079780612 0.856817441772257 -0.222940246332548 0.104103319377395 1 16.6647 17.5539 15.0516 14.1601 GeneID:23141,Genbank:NM_015114.2,HGNC:HGNC:29101,MIM:616062 ankyrin repeat and LEM domain containing 2 GO:0005789,GO:0007084,GO:0007417,GO:0016020,GO:0019888,GO:0030176,GO:0035307,GO:0042326,GO:0043066,GO:0050790,GO:0051301,GO:0051721 endoplasmic reticulum membrane|mitotic nuclear envelope reassembly|central nervous system development|membrane|protein phosphatase regulator activity|integral component of endoplasmic reticulum membrane|positive regulation of protein dephosphorylation|negative regulation of phosphorylation|negative regulation of apoptotic process|regulation of catalytic activity|cell division|protein phosphatase 2A binding ANKMY1 207.53760775932 209.122150463428 205.953065055213 0.984845768842792 -0.0220302849860128 0.929717247448654 1 0.64839 0.792968 0.720163 0.76682 GeneID:51281,Genbank:XM_024452954.1,HGNC:HGNC:20987 ankyrin repeat and MYND domain containing 1 GO:0046872 metal ion binding ANKMY2 502.735227590583 529.065030351556 476.405424829611 0.900466667609928 -0.151255221714043 0.398006043629639 1 7.18866 6.54226 6.46035 5.67912 GeneID:57037,Genbank:NM_020319.2,HGNC:HGNC:25370 ankyrin repeat and MYND domain containing 2 GO:0005929,GO:0008589,GO:0019899,GO:0046872 cilium|regulation of smoothened signaling pathway|enzyme binding|metal ion binding ANKRA2 341.223945489126 332.550466170073 349.89742480818 1.05216338692256 0.0733587532994987 0.706680897591389 1 4.89112 5.40156 5.25881 4.85498 GeneID:57763,Genbank:NM_023039.4,HGNC:HGNC:13208,MIM:605787 ankyrin repeat family A member 2 GO:0003712,GO:0005634,GO:0005829,GO:0005856,GO:0006357,GO:0016020,GO:0019901,GO:0031625,GO:0042826,GO:0043234,GO:0043254,GO:0050750 transcription cofactor activity|nucleus|cytosol|cytoskeleton|regulation of transcription from RNA polymerase II promoter|membrane|protein kinase binding|ubiquitin protein ligase binding|histone deacetylase binding|protein complex|regulation of protein complex assembly|low-density lipoprotein particle receptor binding ANKRD1 2522.23902380488 2540.4999320153 2503.97811559445 0.985624161622444 -0.0208904721483559 0.901364180553411 1 41.1983 38.4766 38.7674 40.6699 GeneID:27063,Genbank:NM_014391.2,HGNC:HGNC:15819,MIM:609599 ankyrin repeat domain 1 GO:0000122,GO:0001085,GO:0001105,GO:0001650,GO:0002039,GO:0003677,GO:0003714,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0010976,GO:0019216,GO:0031432,GO:0031674,GO:0035690,GO:0035914,GO:0035994,GO:0042826,GO:0043065,GO:0043517,GO:0045214,GO:0045445,GO:0050714,GO:0055008,GO:0061629,GO:0070412,GO:0071222,GO:0071260,GO:0071347,GO:0071356,GO:0071407,GO:0071456,GO:0071560,GO:2000279 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor binding|RNA polymerase II transcription coactivator activity|fibrillar center|p53 binding|DNA binding|transcription corepressor activity|nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytosol|positive regulation of neuron projection development|regulation of lipid metabolic process|titin binding|I band|cellular response to drug|skeletal muscle cell differentiation|response to muscle stretch|histone deacetylase binding|positive regulation of apoptotic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|sarcomere organization|myoblast differentiation|positive regulation of protein secretion|cardiac muscle tissue morphogenesis|RNA polymerase II sequence-specific DNA binding transcription factor binding|R-SMAD binding|cellular response to lipopolysaccharide|cellular response to mechanical stimulus|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to organic cyclic compound|cellular response to hypoxia|cellular response to transforming growth factor beta stimulus|negative regulation of DNA biosynthetic process ANKRD10 1054.35990195049 1115.66829448426 993.051509416729 0.890095662237839 -0.167967698112218 0.285666573775926 1 3.46888 3.01501 3.20632 2.67457 GeneID:55608,Genbank:NM_017664.3,HGNC:HGNC:20265 ankyrin repeat domain 10 GO:0060828 regulation of canonical Wnt signaling pathway ANKRD11 3484.0112937651 3480.52990385267 3487.49268367753 1.00200049418255 0.00288322006460284 0.994502651714059 1 7.5364 7.8027 8.35477 7.27962 GeneID:29123,Genbank:XM_017023182.2,HGNC:HGNC:21316,MIM:611192 ankyrin repeat domain 11 GO:0001701,GO:0001894,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0035264,GO:0042475,GO:0048705,GO:0060325,GO:0060348 in utero embryonic development|tissue homeostasis|nucleus|nucleoplasm|cytosol|plasma membrane|multicellular organism growth|odontogenesis of dentin-containing tooth|skeletal system morphogenesis|face morphogenesis|bone development ANKRD12 40.6818631401649 41.616834545944 39.7468917343858 0.955067634721382 -0.0663251912446998 0.914371026447059 1 0.11091 0.0981243 0.127569 0.0815632 GeneID:23253,Genbank:NM_015208.4,HGNC:HGNC:29135,MIM:610616 ankyrin repeat domain 12 GO:0005654,GO:0005829 nucleoplasm|cytosol ANKRD13A 1669.38341201414 1666.84538985455 1671.92143417373 1.00304530003207 0.00438676313436278 0.968858761099744 1 14.2032 13.8957 14.4042 14.6216 GeneID:88455,Genbank:XM_005253984.1,HGNC:HGNC:21268,MIM:615123 ankyrin repeat domain 13A GO:0005737,GO:0005770,GO:0005886 cytoplasm|late endosome|plasma membrane ANKRD13B 368.092087156115 329.081748736794 407.102425575437 1.23708600412551 0.306945802183512 0.105109186525516 1 2.66657 2.5902 3.45921 3.02178 GeneID:124930,Genbank:XM_017024174.2,HGNC:HGNC:26363,MIM:615124 ankyrin repeat domain 13B GO:0005737,GO:0005769,GO:0005770,GO:0005886,GO:0043231 cytoplasm|early endosome|late endosome|plasma membrane|intracellular membrane-bounded organelle ANKRD13C 565.272228113286 608.080161924567 522.464294302004 0.859202991672035 -0.218929078213368 0.206153526011326 1 3.9158 3.70609 3.73038 2.95973 GeneID:81573,Genbank:NM_030816.4,HGNC:HGNC:25374,MIM:615125 ankyrin repeat domain 13C GO:0005102,GO:0005783,GO:0005789,GO:0006621,GO:0010869,GO:0048471,GO:2000209 receptor binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein retention in ER lumen|regulation of receptor biosynthetic process|perinuclear region of cytoplasm|regulation of anoikis ANKRD13D 501.273351987539 496.616490619602 505.930213355477 1.0187543565544 0.0268062288318044 0.910170429703404 1 4.68374 5.03021 4.84344 5.1139 GeneID:338692,Genbank:NM_001347901.1,HGNC:HGNC:27880,MIM:615126 ankyrin repeat domain 13D GO:0005737,GO:0005770,GO:0005886 cytoplasm|late endosome|plasma membrane ANKRD16 108.330424461423 111.494114271144 105.166734651702 0.943249205029296 -0.0842891157552643 0.772028405971202 1 1.27348 1.34605 1.47154 1.35638 GeneID:54522,Genbank:NM_019046.2,HGNC:HGNC:23471 ankyrin repeat domain 16 ANKRD17 2193.99149024926 2241.29190448683 2146.69107601168 0.957791830557291 -0.0622159646639883 0.796697098577223 1 5.97489 5.25612 6.36608 4.52402 GeneID:26057,Genbank:NM_198889.2,HGNC:HGNC:23575,MIM:615929 ankyrin repeat domain 17 GO:0000785,GO:0001955,GO:0003682,GO:0003723,GO:0005634,GO:0005737,GO:0006275,GO:0016020,GO:0016032,GO:0031965,GO:0042742,GO:0043123,GO:0045087,GO:0045787,GO:0051151,GO:1900087,GO:1900245,GO:1900246 chromatin|blood vessel maturation|chromatin binding|RNA binding|nucleus|cytoplasm|regulation of DNA replication|membrane|viral process|nuclear membrane|defense response to bacterium|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of cell cycle|negative regulation of smooth muscle cell differentiation|positive regulation of G1/S transition of mitotic cell cycle|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway ANKRD18B 2.49044364938977 3.52655236307142 1.45433493570811 0.412395673161499 -1.27789889879918 0.588158621281267 1 0 0.0256622 0.0169586 0 GeneID:441459,Genbank:NM_001353432.1,HGNC:HGNC:23644 ankyrin repeat domain 18B ANKRD2 6.64199710559158 5.04479284362845 8.23920136755471 1.63320905792213 0.707709474012401 0.590635096338978 1 0.0956536 0.195972 0.178452 0.16548 GeneID:26287,Genbank:NM_001346793.1,HGNC:HGNC:495,MIM:610734 ankyrin repeat domain 2 GO:0000122,GO:0000791,GO:0001817,GO:0003682,GO:0003712,GO:0005634,GO:0005829,GO:0006936,GO:0007517,GO:0008307,GO:0010832,GO:0016605,GO:0031432,GO:0031674,GO:0035914,GO:0043231,GO:0043422,GO:0043619,GO:0045662,GO:0061629,GO:1902253,GO:2000291 negative regulation of transcription from RNA polymerase II promoter|euchromatin|regulation of cytokine production|chromatin binding|transcription cofactor activity|nucleus|cytosol|muscle contraction|muscle organ development|structural constituent of muscle|negative regulation of myotube differentiation|PML body|titin binding|I band|skeletal muscle cell differentiation|intracellular membrane-bounded organelle|protein kinase B binding|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|negative regulation of myoblast differentiation|RNA polymerase II sequence-specific DNA binding transcription factor binding|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|regulation of myoblast proliferation ANKRD20A1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0100545 0 0 0 GeneID:84210,Genbank:NM_032250.3,HGNC:HGNC:23665 ankyrin repeat domain 20 family member A1 GO:0005886 plasma membrane ANKRD20A2 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0161174 0.00745644 GeneID:441430,Genbank:XM_011517877.3,HGNC:HGNC:31979 ankyrin repeat domain 20 family member A2 ANKRD20A3 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0 GeneID:441425,Genbank:XM_011543860.3,HGNC:HGNC:31981 ankyrin repeat domain 20 family member A3 ANKRD23 34.4143933413282 29.5669632508577 39.2618234317987 1.32789502590056 0.409141101806346 0.390420804622156 1 0.537792 0.309805 0.569018 0.467374 GeneID:200539,Genbank:NM_144994.7,HGNC:HGNC:24470,MIM:610736 ankyrin repeat domain 23 GO:0005654,GO:0005829,GO:0009612,GO:0014704,GO:0015629,GO:0030016,GO:0031432 nucleoplasm|cytosol|response to mechanical stimulus|intercalated disc|actin cytoskeleton|myofibril|titin binding ANKRD24 7.36516383358393 8.9173377846024 5.81298988256547 0.651875035237846 -0.617332669268437 0.709294925281149 1 0 0.057078 0.00759093 0.0425476 GeneID:170961,Genbank:XM_011527756.2,HGNC:HGNC:29424 ankyrin repeat domain 24 ANKRD26 28.346058960472 31.9692939859595 24.7228239349845 0.773330307070354 -0.370843341036156 0.510835524872402 1 0.0278534 0.0235985 0.0269344 0.0156409 GeneID:22852,Genbank:XM_017015929.1,HGNC:HGNC:29186,MIM:610855 ankyrin repeat domain 26 GO:0005813,GO:0045599 centrosome|negative regulation of fat cell differentiation ANKRD27 920.101515281033 904.309543421712 935.893487140355 1.03492603163197 0.0495276589215349 0.76093160845429 1 5.90953 6.56293 7.49599 5.79761 GeneID:84079,Genbank:NM_032139.2,HGNC:HGNC:25310 ankyrin repeat domain 27 GO:0000149,GO:0005085,GO:0005096,GO:0005764,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0015031,GO:0016020,GO:0017112,GO:0017137,GO:0030133,GO:0030659,GO:0035544,GO:0035646,GO:0042470,GO:0043005,GO:0045022,GO:0048812,GO:0050775,GO:0097422,GO:1990126 SNARE binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|lysosome|early endosome|late endosome|cytosol|plasma membrane|protein transport|membrane|Rab guanyl-nucleotide exchange factor activity|Rab GTPase binding|transport vesicle|cytoplasmic vesicle membrane|negative regulation of SNARE complex assembly|endosome to melanosome transport|melanosome|neuron projection|early endosome to late endosome transport|neuron projection morphogenesis|positive regulation of dendrite morphogenesis|tubular endosome|retrograde transport, endosome to plasma membrane ANKRD28 869.388709482874 951.603287035587 787.174131930162 0.827208294311749 -0.273677443443368 0.347381190778721 1 3.78289 3.24496 3.62778 2.25197 GeneID:23243,Genbank:XM_024453418.1,HGNC:HGNC:29024,MIM:611122 ankyrin repeat domain 28 GO:0000139,GO:0005654,GO:0005829,GO:0048208 Golgi membrane|nucleoplasm|cytosol|COPII vesicle coating ANKRD29 27.7064577428681 24.8779716402397 30.5349438454966 1.22738880351913 0.295592328101581 0.624351611875691 1 0.113818 0.196431 0.232058 0.177945 GeneID:147463,Genbank:XM_017025561.1,HGNC:HGNC:27110 ankyrin repeat domain 29 ANKRD31 1.80249284908527 2.15239070656922 1.45259499160132 0.674875145654512 -0.56730747184403 0.971482606599152 1 0.0197657 0 0 0.00890153 GeneID:256006,Genbank:XM_011543301.3,HGNC:HGNC:26853 ankyrin repeat domain 31 ANKRD33B 283.587682027854 325.315065000298 241.860299055411 0.743464797903501 -0.427663660736572 0.0345517452486532 0.730000079237491 1.48039 1.5482 1.31378 0.941199 GeneID:651746,Genbank:NM_001164440.1,HGNC:HGNC:35240 ankyrin repeat domain 33B ANKRD34A 58.9841820297826 69.9831409296781 47.9852231298872 0.685668326577463 -0.54441721428343 0.235221037302639 1 0.571707 0.862934 0.672763 0.416078 GeneID:284615,Genbank:NM_001039888.3,HGNC:HGNC:27639 ankyrin repeat domain 34A ANKRD36 13.4561334342758 15.2784573549402 11.6338095136115 0.761451843163329 -0.393175296292121 0.634675777994394 1 0.0343726 0.0334786 0.02667 0.0185841 GeneID:375248,Genbank:NM_001354587.1,HGNC:HGNC:24079 ankyrin repeat domain 36 ANKRD36B 16.2396165584755 16.0086601303222 16.4705729866289 1.02885393609123 0.0410381808380732 0.992552047352526 1 0.0455804 0.0481289 0.0331523 0.0615591 GeneID:57730,Genbank:XM_006712661.2,HGNC:HGNC:29333 ankyrin repeat domain 36B ANKRD36C 15.9152535293644 12.9241528945232 18.9063541642055 1.46286989317631 0.548801462698378 0.452339627853364 1 0.0428393 0.0243813 0.0554594 0.0386398 GeneID:400986,Genbank:NM_001310154.1,HGNC:HGNC:32946 ankyrin repeat domain 36C GO:0008200 ion channel inhibitor activity ANKRD37 58.5394579636627 56.9913444502541 60.0875714770713 1.05432802220554 0.0763237876440877 0.858655015382363 1 1.47473 1.98017 1.69322 2.42613 GeneID:353322,Genbank:NM_181726.3,HGNC:HGNC:29593 ankyrin repeat domain 37 GO:0005634,GO:0005739,GO:0005829 nucleus|mitochondrion|cytosol ANKRD39 254.690676950362 253.016854230635 256.364499670089 1.01323091874505 0.0189630066790105 0.969551725531067 1 11.0166 13.4516 12.9343 12.9263 GeneID:51239,Genbank:NM_016466.5,HGNC:HGNC:28640 ankyrin repeat domain 39 ANKRD40 1998.07227872823 2075.45094187567 1920.69361558078 0.925434360710532 -0.111797428763073 0.437569744104952 1 19.0767 17.9912 19.1541 15.7772 GeneID:91369,Genbank:NM_052855.3,HGNC:HGNC:28233 ankyrin repeat domain 40 ANKRD42 174.487784152336 181.303750411444 167.671817893229 0.924811635240423 -0.112768546099308 0.651964587039211 1 1.18652 1.16348 1.06883 1.1233 GeneID:338699,Genbank:NM_001300972.1,HGNC:HGNC:26752 ankyrin repeat domain 42 GO:0005634,GO:0051059,GO:0051091,GO:0051092,GO:1900017 nucleus|NF-kappaB binding|positive regulation of DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of cytokine production involved in inflammatory response ANKRD44 112.486864847271 120.285973541053 104.687756153489 0.870323887911665 -0.200375700217407 0.508627783201159 1 0.391742 0.303076 0.358617 0.308102 GeneID:91526,Genbank:XM_005246948.2,HGNC:HGNC:25259 ankyrin repeat domain 44 ANKRD45 19.5413623509992 25.5121218662519 13.5706028357466 0.531927642353345 -0.910698084344578 0.156759124388378 1 0.0910728 0.141836 0.080902 0.0522793 GeneID:339416,Genbank:NM_198493.2,HGNC:HGNC:24786 ankyrin repeat domain 45 ANKRD46 147.08651277231 178.833776091441 115.339249453179 0.64495226782106 -0.632735702608866 0.0323255626835249 0.712140594139387 2.02585 1.60349 1.14452 1.11346 GeneID:157567,Genbank:NM_001270379.1,HGNC:HGNC:27229 ankyrin repeat domain 46 GO:0016021 integral component of membrane ANKRD49 126.708678447991 142.925310580462 110.49204631552 0.773075432663255 -0.37131890322149 0.168484044158554 1 2.35442 2.70017 2.02027 2.11011 GeneID:54851,Genbank:NM_017704.2,HGNC:HGNC:25970 ankyrin repeat domain 49 GO:0005634,GO:0007283,GO:0030154,GO:0045893 nucleus|spermatogenesis|cell differentiation|positive regulation of transcription, DNA-templated ANKRD50 488.771164848842 512.229097895627 465.313231802057 0.908408432308293 -0.138586996952541 0.675128039937478 1 2.44039 1.9334 2.40321 1.59978 GeneID:57182,Genbank:NM_020337.2,HGNC:HGNC:29223 ankyrin repeat domain 50 GO:0005768,GO:0015031,GO:1990126 endosome|protein transport|retrograde transport, endosome to plasma membrane ANKRD52 3911.73755735004 3224.1610190492 4599.31409565089 1.42651501227046 0.512494929544363 0.0559033087464924 0.857612445291018 13.8925 14.6796 24.628 16.9838 GeneID:283373,Genbank:NM_173595.3,HGNC:HGNC:26614 ankyrin repeat domain 52 ANKRD53 41.3037349856133 41.9148008491616 40.692669122065 0.970842478018812 -0.042690861669855 0.963633665719709 1 0.246346 0.254688 0.1241 0.331275 GeneID:79998,Genbank:XM_005264569.5,HGNC:HGNC:25691,MIM:617009 ankyrin repeat domain 53 GO:0000922,GO:0005737,GO:0005819,GO:0007080,GO:0031116,GO:0051301,GO:0060236,GO:1902412 spindle pole|cytoplasm|spindle|mitotic metaphase plate congression|positive regulation of microtubule polymerization|cell division|regulation of mitotic spindle organization|regulation of mitotic cytokinesis ANKRD54 650.744409667918 591.996083555946 709.492735779889 1.19847538773935 0.261200281660402 0.119986638113338 1 5.53347 6.19079 7.18951 6.90607 GeneID:129138,Genbank:XM_011529877.2,HGNC:HGNC:25185,MIM:613383 ankyrin repeat domain 54 GO:0005634,GO:0005737,GO:0006913,GO:0019887,GO:0030496,GO:0032403,GO:0045648,GO:1902531 nucleus|cytoplasm|nucleocytoplasmic transport|protein kinase regulator activity|midbody|protein complex binding|positive regulation of erythrocyte differentiation|regulation of intracellular signal transduction ANKRD55 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00785092 GeneID:79722,Genbank:NM_024669.2,HGNC:HGNC:25681,MIM:615189 ankyrin repeat domain 55 ANKRD6 204.624222960784 196.486155217014 212.762290704554 1.08283604241512 0.114814813858863 0.61888070007219 1 0.730502 0.788501 0.9555 0.814497 GeneID:22881,Genbank:NM_001242809.1,HGNC:HGNC:17280,MIM:610583 ankyrin repeat domain 6 GO:0005634,GO:0005737,GO:0043231,GO:0046330,GO:0090090,GO:2000096 nucleus|cytoplasm|intracellular membrane-bounded organelle|positive regulation of JNK cascade|negative regulation of canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway ANKRD61 6.53584289720102 8.22535262879733 4.84633316560471 0.589194577340974 -0.763183942312795 0.546553233307105 1 0.207833 0.188065 0.121784 0.090964 GeneID:100310846,Genbank:NM_001271700.1,HGNC:HGNC:22467 ankyrin repeat domain 61 ANKRD63 5.51441686207834 7.14915727551272 3.87967644864396 0.54267605245343 -0.881836848946994 0.521175668072941 1 0.0917479 0.093656 0.0993427 0.013303 GeneID:100131244,Genbank:NM_001190479.2,HGNC:HGNC:40027 ankyrin repeat domain 63 ANKRD65 2.99484860950082 3.084507235799 2.90518998320264 0.941865186596032 -0.0864075197076172 1 1 0.031198 0.0406272 0 0.0813364 GeneID:441869,Genbank:XM_017001324.2,HGNC:HGNC:42950 ankyrin repeat domain 65 ANKRD7 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0322013 0 GeneID:56311,Genbank:NM_019644.3,HGNC:HGNC:18588,MIM:610731 ankyrin repeat domain 7 GO:0008584 male gonad development ANKRD9 891.90543618773 808.248790985525 975.562081389935 1.20700716446529 0.271434239562582 0.0888715416259404 0.975576840768376 6.74833 7.961 9.23092 8.85676 GeneID:122416,Genbank:NM_001348652.1,HGNC:HGNC:20096 ankyrin repeat domain 9 GO:0005829,GO:0043687 cytosol|post-translational protein modification ANKS1A 1088.3155110875 1044.95698478091 1131.67403739409 1.08298624142061 0.115014914635675 0.446834120063952 1 2.81022 2.70115 3.25294 2.77831 GeneID:23294,Genbank:NM_015245.2,HGNC:HGNC:20961,MIM:608994 ankyrin repeat and sterile alpha motif domain containing 1A GO:0005654,GO:0005829,GO:0006929,GO:0016322,GO:0043005,GO:0046875,GO:0048013,GO:1901187 nucleoplasm|cytosol|substrate-dependent cell migration|neuron remodeling|neuron projection|ephrin receptor binding|ephrin receptor signaling pathway|regulation of ephrin receptor signaling pathway ANKS1B 51.1762748281157 52.436623008583 49.9159266476485 0.951928705238666 -0.0710745680455795 0.890340282916407 1 0.106243 0.0919054 0.0691596 0.088708 GeneID:56899,Genbank:XM_006719507.4,HGNC:HGNC:24600,MIM:607815 ankyrin repeat and sterile alpha motif domain containing 1B GO:0005634,GO:0005829,GO:0005886,GO:0014069,GO:0030054,GO:0043197,GO:0043231,GO:0045211,GO:0046875,GO:0097120,GO:1900383 nucleus|cytosol|plasma membrane|postsynaptic density|cell junction|dendritic spine|intracellular membrane-bounded organelle|postsynaptic membrane|ephrin receptor binding|receptor localization to synapse|regulation of synaptic plasticity by receptor localization to synapse ANKS3 292.394034589859 308.095939347744 276.692129831973 0.898071329397413 -0.155098059184718 0.480198203961536 1 2.97938 3.30456 2.73163 3.23411 GeneID:124401,Genbank:NM_001324129.1,HGNC:HGNC:29422,MIM:617310 ankyrin repeat and sterile alpha motif domain containing 3 ANKS6 624.726593745722 635.899578977406 613.553608514037 0.964859277782031 -0.0516095504861282 0.747160782835897 1 2.18452 2.35111 2.43242 2.169 GeneID:203286,Genbank:NM_173551.4,HGNC:HGNC:26724,MIM:615370 ankyrin repeat and sterile alpha motif domain containing 6 GO:0005737,GO:0005929 cytoplasm|cilium ANKUB1 70.2926814450096 58.2116186275935 82.3737442624258 1.41507393548715 0.500877433674846 0.145204154148771 1 0.556315 0.570237 0.624422 0.972271 GeneID:389161,Genbank:XM_011512798.1,HGNC:HGNC:29642 ankyrin repeat and ubiquitin domain containing 1 ANKZF1 451.132872159748 452.059227661913 450.206516657583 0.995901618878764 -0.00592486360408234 0.952775379572245 1 4.78927 5.3048 5.05381 4.74611 GeneID:55139,Genbank:NM_018089.2,HGNC:HGNC:25527,MIM:617541 ankyrin repeat and zinc finger domain containing 1 GO:0003676,GO:0005737,GO:0016020,GO:0030433,GO:0036266,GO:0046872,GO:0070301,GO:0071630,GO:0072671 nucleic acid binding|cytoplasm|membrane|ubiquitin-dependent ERAD pathway|Cdc48p-Npl4p-Vms1p AAA ATPase complex|metal ion binding|cellular response to hydrogen peroxide|nuclear protein quality control by the ubiquitin-proteasome system|mitochondria-associated ubiquitin-dependent protein catabolic process ANLN 2839.21643296783 3031.42360290673 2647.00926302893 0.873190160718811 -0.19563222104303 0.518408780831432 1 23.2968 19.897 23.3219 15.0786 GeneID:54443,Genbank:NM_018685.4,HGNC:HGNC:14082,MIM:616027 anillin actin binding protein ANO1 12.2358496622775 14.2983145510254 10.1733847735296 0.711509369669028 -0.491045339560711 0.571954608149294 1 0.0760041 0.0887597 0.0357499 0.0732858 GeneID:55107,Genbank:NM_018043.5,HGNC:HGNC:21625,MIM:610108 anoctamin 1 GO:0005227,GO:0005229,GO:0005247,GO:0005254,GO:0005737,GO:0005886,GO:0006812,GO:0006821,GO:0007200,GO:0007275,GO:0015111,GO:0015705,GO:0016324,GO:0034220,GO:0034605,GO:0034707,GO:0035774,GO:0046983,GO:0050965,GO:0070062,GO:1902476 calcium activated cation channel activity|intracellular calcium activated chloride channel activity|voltage-gated chloride channel activity|chloride channel activity|cytoplasm|plasma membrane|cation transport|chloride transport|phospholipase C-activating G-protein coupled receptor signaling pathway|multicellular organism development|iodide transmembrane transporter activity|iodide transport|apical plasma membrane|ion transmembrane transport|cellular response to heat|chloride channel complex|positive regulation of insulin secretion involved in cellular response to glucose stimulus|protein dimerization activity|detection of temperature stimulus involved in sensory perception of pain|extracellular exosome|chloride transmembrane transport ANO10 1506.30726109052 1466.66121148679 1545.95331069425 1.05406299599829 0.075961092115959 0.610343469768097 1 10.4925 11.472 12.0444 11.4494 GeneID:55129,Genbank:NM_001346469.1,HGNC:HGNC:25519,MIM:613726 anoctamin 10 GO:0005227,GO:0005229,GO:0005622,GO:0005886,GO:0006812,GO:0006821,GO:0016020,GO:0016021,GO:0034220 calcium activated cation channel activity|intracellular calcium activated chloride channel activity|intracellular|plasma membrane|cation transport|chloride transport|membrane|integral component of membrane|ion transmembrane transport ANO2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00376731 0 GeneID:57101,Genbank:XM_011520975.2,HGNC:HGNC:1183,MIM:610109 anoctamin 2 GO:0005229,GO:0005654,GO:0005886,GO:0034220,GO:0034707,GO:0042803,GO:0046982,GO:0097730 intracellular calcium activated chloride channel activity|nucleoplasm|plasma membrane|ion transmembrane transport|chloride channel complex|protein homodimerization activity|protein heterodimerization activity|non-motile cilium hsa04740 Olfactory transduction ANO3 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00377245 0 GeneID:63982,Genbank:NM_001313726.1,HGNC:HGNC:14004,MIM:610110 anoctamin 3 GO:0005229,GO:0005886,GO:0016021,GO:0016048,GO:0017128,GO:0034220,GO:0046983,GO:0050982,GO:0061590,GO:0061591 intracellular calcium activated chloride channel activity|plasma membrane|integral component of membrane|detection of temperature stimulus|phospholipid scramblase activity|ion transmembrane transport|protein dimerization activity|detection of mechanical stimulus|calcium activated phosphatidylcholine scrambling|calcium activated galactosylceramide scrambling ANO4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:121601,Genbank:XM_011537912.2,HGNC:HGNC:23837,MIM:610111 anoctamin 4 GO:0005229,GO:0005622,GO:0005886,GO:0006821,GO:0016021,GO:0017128,GO:0034220,GO:0046983,GO:0061589,GO:0061590,GO:0061591 intracellular calcium activated chloride channel activity|intracellular|plasma membrane|chloride transport|integral component of membrane|phospholipid scramblase activity|ion transmembrane transport|protein dimerization activity|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|calcium activated galactosylceramide scrambling ANO6 1583.2608728905 1570.86005565666 1595.66169012434 1.01578857033023 0.0226001459302497 0.92502768575097 1 8.59076 8.49926 10.5689 6.97914 GeneID:196527,Genbank:NM_001142679.1,HGNC:HGNC:25240,MIM:608663 anoctamin 6 GO:0002407,GO:0002543,GO:0005227,GO:0005229,GO:0005244,GO:0005247,GO:0005622,GO:0005829,GO:0005886,GO:0006812,GO:0006821,GO:0007596,GO:0009986,GO:0016020,GO:0017121,GO:0017128,GO:0030501,GO:0032060,GO:0034220,GO:0034707,GO:0034767,GO:0035579,GO:0035590,GO:0035630,GO:0035725,GO:0042803,GO:0043065,GO:0043312,GO:0045794,GO:0046931,GO:0060100,GO:0061589,GO:0061590,GO:0061591,GO:0070062,GO:0070588,GO:0070821,GO:0090026,GO:0097045,GO:1902304,GO:1902476,GO:2000353 dendritic cell chemotaxis|activation of blood coagulation via clotting cascade|calcium activated cation channel activity|intracellular calcium activated chloride channel activity|voltage-gated ion channel activity|voltage-gated chloride channel activity|intracellular|cytosol|plasma membrane|cation transport|chloride transport|blood coagulation|cell surface|membrane|phospholipid scrambling|phospholipid scramblase activity|positive regulation of bone mineralization|bleb assembly|ion transmembrane transport|chloride channel complex|positive regulation of ion transmembrane transport|specific granule membrane|purinergic nucleotide receptor signaling pathway|bone mineralization involved in bone maturation|sodium ion transmembrane transport|protein homodimerization activity|positive regulation of apoptotic process|neutrophil degranulation|negative regulation of cell volume|pore complex assembly|positive regulation of phagocytosis, engulfment|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|calcium activated galactosylceramide scrambling|extracellular exosome|calcium ion transmembrane transport|tertiary granule membrane|positive regulation of monocyte chemotaxis|phosphatidylserine exposure on blood platelet|positive regulation of potassium ion export|chloride transmembrane transport|positive regulation of endothelial cell apoptotic process ANO7 146.545653262786 155.455444622397 137.635861903174 0.885371768338463 -0.175644723628519 0.498995532037199 1 0.264532 0.329003 0.322613 0.366186 GeneID:50636,Genbank:NM_001001891.3,HGNC:HGNC:31677,MIM:605096 anoctamin 7 GO:0005229,GO:0005622,GO:0005634,GO:0005783,GO:0005829,GO:0005886,GO:0006821,GO:0016021,GO:0017128,GO:0030054,GO:0034220,GO:0046983,GO:0061589,GO:0061590,GO:0061591 intracellular calcium activated chloride channel activity|intracellular|nucleus|endoplasmic reticulum|cytosol|plasma membrane|chloride transport|integral component of membrane|phospholipid scramblase activity|cell junction|ion transmembrane transport|protein dimerization activity|calcium activated phosphatidylserine scrambling|calcium activated phosphatidylcholine scrambling|calcium activated galactosylceramide scrambling ANO8 1071.33468803946 1032.88953017732 1109.77984590161 1.07444195480527 0.103587545328231 0.517426485700172 1 8.73625 9.64943 10.4769 10.1867 GeneID:57719,Genbank:XM_017027048.1,HGNC:HGNC:29329,MIM:610216 anoctamin 8 GO:0005229,GO:0005788,GO:0005886,GO:0006821,GO:0016021,GO:0034220,GO:0043687,GO:0044267 intracellular calcium activated chloride channel activity|endoplasmic reticulum lumen|plasma membrane|chloride transport|integral component of membrane|ion transmembrane transport|post-translational protein modification|cellular protein metabolic process ANOS1 2.42523314646075 0.490071401957362 4.36039489096415 8.89746855978247 3.15339492981699 0.226471222102712 1 0 0.00604704 0.0183483 0.0342002 GeneID:3730,Genbank:NM_000216.3,HGNC:HGNC:6211,MIM:300836 anosmin 1 GO:0004867,GO:0005201,GO:0005576,GO:0005578,GO:0005615,GO:0005886,GO:0006928,GO:0006935,GO:0007155,GO:0007411,GO:0008201,GO:0008543 serine-type endopeptidase inhibitor activity|extracellular matrix structural constituent|extracellular region|proteinaceous extracellular matrix|extracellular space|plasma membrane|movement of cell or subcellular component|chemotaxis|cell adhesion|axon guidance|heparin binding|fibroblast growth factor receptor signaling pathway ANP32A 3723.49656946202 3973.78927889516 3473.20386002889 0.874028192303783 -0.194248279416767 0.151598255010558 1 53.7951 53.9691 46.7361 48.6668 GeneID:8125,Genbank:NM_006305.3,HGNC:HGNC:13233,MIM:600832 acidic nuclear phosphoprotein 32 family member A GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0006351,GO:0006355,GO:0006913,GO:0035556,GO:0042393,GO:0042981,GO:0043488,GO:0048471 RNA binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|transcription, DNA-templated|regulation of transcription, DNA-templated|nucleocytoplasmic transport|intracellular signal transduction|histone binding|regulation of apoptotic process|regulation of mRNA stability|perinuclear region of cytoplasm ANP32B 3610.52827461681 3802.55753086246 3418.49901837116 0.898999946910942 -0.153607064343772 0.253041062322667 1 59.8054 62.2754 55.3209 55.8619 GeneID:10541,Genbank:NM_006401.2,HGNC:HGNC:16677 acidic nuclear phosphoprotein 32 family member B GO:0001944,GO:0005634,GO:0005737,GO:0006334,GO:0006919,GO:0021591,GO:0042393,GO:0043486,GO:0045596,GO:0046827,GO:0048839,GO:0060021,GO:0070062,GO:0070063 vasculature development|nucleus|cytoplasm|nucleosome assembly|activation of cysteine-type endopeptidase activity involved in apoptotic process|ventricular system development|histone binding|histone exchange|negative regulation of cell differentiation|positive regulation of protein export from nucleus|inner ear development|palate development|extracellular exosome|RNA polymerase binding ANP32C 15.4147778698147 20.1693627194059 10.6601930202236 0.52853395362695 -0.919931939919387 0.219263875545744 1 0 0 0 0 GeneID:23520,Genbank:NM_012403.1,HGNC:HGNC:16675,MIM:606877 acidic nuclear phosphoprotein 32 family member C GO:0005634,GO:0006913,GO:0042393,GO:0042981 nucleus|nucleocytoplasmic transport|histone binding|regulation of apoptotic process ANP32E 1886.22112786884 2094.03136952705 1678.41088621063 0.801521367174984 -0.319187114237426 0.180085622639183 1 21.4268 17.6689 18.0091 14.0149 GeneID:81611,Genbank:NM_001136478.3,HGNC:HGNC:16673,MIM:609611 acidic nuclear phosphoprotein 32 family member E GO:0000812,GO:0005634,GO:0006334,GO:0006913,GO:0016569,GO:0019212,GO:0031410,GO:0042393,GO:0042981,GO:0043486 Swr1 complex|nucleus|nucleosome assembly|nucleocytoplasmic transport|covalent chromatin modification|phosphatase inhibitor activity|cytoplasmic vesicle|histone binding|regulation of apoptotic process|histone exchange ANPEP 44.521331676536 38.6381885146228 50.4044748384492 1.30452479208163 0.383524362379471 0.395550881697434 1 0.26079 0.340139 0.418677 0.286568 GeneID:290,Genbank:XM_011521473.1,HGNC:HGNC:500,MIM:151530 alanyl aminopeptidase, membrane GO:0001525,GO:0001618,GO:0004177,GO:0004872,GO:0005615,GO:0005765,GO:0005793,GO:0005886,GO:0007165,GO:0007267,GO:0008217,GO:0008237,GO:0008270,GO:0009897,GO:0016021,GO:0030154,GO:0030667,GO:0042277,GO:0043171,GO:0043312,GO:0070006,GO:0070062 angiogenesis|virus receptor activity|aminopeptidase activity|receptor activity|extracellular space|lysosomal membrane|endoplasmic reticulum-Golgi intermediate compartment|plasma membrane|signal transduction|cell-cell signaling|regulation of blood pressure|metallopeptidase activity|zinc ion binding|external side of plasma membrane|integral component of membrane|cell differentiation|secretory granule membrane|peptide binding|peptide catabolic process|neutrophil degranulation|metalloaminopeptidase activity|extracellular exosome hsa00480,hsa04614,hsa04640 Glutathione metabolism|Renin-angiotensin system|Hematopoietic cell lineage ANTXR1 1848.12351032948 1702.30200158315 1993.94501907582 1.1713227248875 0.228138624471321 0.143692142028771 1 4.91272 4.60817 6.32821 4.92377 GeneID:84168,Genbank:NM_032208.2,HGNC:HGNC:21014,MIM:606410 anthrax toxin receptor 1 GO:0001568,GO:0004888,GO:0005518,GO:0005886,GO:0009897,GO:0009986,GO:0010008,GO:0016021,GO:0022414,GO:0031258,GO:0031527,GO:0031532,GO:0034446,GO:0046872,GO:0051015,GO:0070062,GO:1901202,GO:1905050 blood vessel development|transmembrane signaling receptor activity|collagen binding|plasma membrane|external side of plasma membrane|cell surface|endosome membrane|integral component of membrane|reproductive process|lamellipodium membrane|filopodium membrane|actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading|metal ion binding|actin filament binding|extracellular exosome|negative regulation of extracellular matrix assembly|positive regulation of metallopeptidase activity hsa04621 NOD-like receptor signaling pathway ANTXR2 428.492653679581 435.789801847096 421.195505512067 0.96651069787964 -0.0491423938088548 0.836087444328348 1 1.76538 1.76633 2.09333 1.49017 GeneID:118429,Genbank:NM_001286780.1,HGNC:HGNC:21732,MIM:608041 anthrax toxin receptor 2 GO:0004872,GO:0005576,GO:0005789,GO:0005886,GO:0009897,GO:0010008,GO:0016021,GO:0022414,GO:0046872,GO:1901998 receptor activity|extracellular region|endoplasmic reticulum membrane|plasma membrane|external side of plasma membrane|endosome membrane|integral component of membrane|reproductive process|metal ion binding|toxin transport hsa04621 NOD-like receptor signaling pathway ANXA1 7810.54072628228 7662.78248067075 7958.29897189381 1.03856516767486 0.0545917449563728 0.66370707753558 1 134.551 131.399 146.879 131.198 GeneID:301,Genbank:NM_000700.2,HGNC:HGNC:533,MIM:151690 annexin A1 ANXA10 3.82937978354524 5.23689794236822 2.42186162472226 0.46246110796405 -1.11259605186743 0.541693294658059 1 0.147773 0.0560642 0 0.105174 GeneID:11199,Genbank:XM_011531571.2,HGNC:HGNC:534,MIM:608008 annexin A10 GO:0005509,GO:0005544,GO:0005739 calcium ion binding|calcium-dependent phospholipid binding|mitochondrion ANXA11 4123.4682994877 4026.4220750059 4220.51452396951 1.0482046952227 0.0679204763660211 0.625972346189484 1 19.6787 20.6875 21.1452 21.4482 GeneID:311,Genbank:XM_011539736.3,HGNC:HGNC:535,MIM:602572 annexin A11 GO:0003723,GO:0005509,GO:0005544,GO:0005635,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0006909,GO:0008429,GO:0016020,GO:0023026,GO:0030496,GO:0032506,GO:0042470,GO:0042581,GO:0042582,GO:0044548,GO:0045335,GO:0048306,GO:0051592,GO:0070062 RNA binding|calcium ion binding|calcium-dependent phospholipid binding|nuclear envelope|nucleoplasm|cytoplasm|spindle|cytosol|phagocytosis|phosphatidylethanolamine binding|membrane|MHC class II protein complex binding|midbody|cytokinetic process|melanosome|specific granule|azurophil granule|S100 protein binding|phagocytic vesicle|calcium-dependent protein binding|response to calcium ion|extracellular exosome ANXA13 8.50208744207548 9.253521707397 7.75065317675395 0.837589560151818 -0.255684634484763 0.85702071966805 1 0.142185 0.108643 0.0449457 0.146409 GeneID:312,Genbank:NM_004306.3,HGNC:HGNC:536,MIM:602573 annexin A13 GO:0001786,GO:0005509,GO:0005544,GO:0005615,GO:0005654,GO:0005886,GO:0016323,GO:0016324,GO:0030154,GO:0042997,GO:0042998,GO:0045121,GO:0070062,GO:0070382,GO:1901611 phosphatidylserine binding|calcium ion binding|calcium-dependent phospholipid binding|extracellular space|nucleoplasm|plasma membrane|basolateral plasma membrane|apical plasma membrane|cell differentiation|negative regulation of Golgi to plasma membrane protein transport|positive regulation of Golgi to plasma membrane protein transport|membrane raft|extracellular exosome|exocytic vesicle|phosphatidylglycerol binding ANXA2 83006.0970137035 88842.0326335235 77170.1613938836 0.868622194994267 -0.203199277947429 0.10985415435637 1 542.703 568.684 462.831 513.912 GeneID:302,Genbank:NM_004039.2,HGNC:HGNC:537,MIM:151740 annexin A2 ANXA2R 67.0620657486722 61.4500133425553 72.6741181547892 1.18265422905061 0.242028336611143 0.650570737027206 1 2.85323 3.21738 2.57255 4.73687 GeneID:389289,Genbank:NM_001014279.2,HGNC:HGNC:33463,MIM:611296 annexin A2 receptor GO:0004872 receptor activity ANXA3 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.0225786 0.0229722 0.0212662 GeneID:306,Genbank:NM_005139.2,HGNC:HGNC:541,MIM:106490 annexin A3 GO:0005509,GO:0005544,GO:0005737,GO:0005829,GO:0005886,GO:0006909,GO:0010595,GO:0016020,GO:0019834,GO:0021766,GO:0030424,GO:0030425,GO:0030670,GO:0031100,GO:0042581,GO:0042742,GO:0043025,GO:0043312,GO:0045766,GO:0048306,GO:0051054,GO:0051091,GO:0051384,GO:0070062,GO:0070848 calcium ion binding|calcium-dependent phospholipid binding|cytoplasm|cytosol|plasma membrane|phagocytosis|positive regulation of endothelial cell migration|membrane|phospholipase A2 inhibitor activity|hippocampus development|axon|dendrite|phagocytic vesicle membrane|animal organ regeneration|specific granule|defense response to bacterium|neuronal cell body|neutrophil degranulation|positive regulation of angiogenesis|calcium-dependent protein binding|positive regulation of DNA metabolic process|positive regulation of DNA binding transcription factor activity|response to glucocorticoid|extracellular exosome|response to growth factor ANXA4 933.847926850052 847.125076871863 1020.57077682824 1.20474627028733 0.268729334718651 0.0791650503247998 0.945390555851746 3.43582 3.21263 3.95805 4.26686 GeneID:307,Genbank:NM_001320698.1,HGNC:HGNC:542,MIM:106491 annexin A4 GO:0004859,GO:0005509,GO:0005544,GO:0005634,GO:0005737,GO:0005886,GO:0006357,GO:0007165,GO:0007219,GO:0009986,GO:0012506,GO:0030855,GO:0031965,GO:0032088,GO:0042802,GO:0043066,GO:0048306,GO:0048471,GO:0051059,GO:0070062,GO:2000483 phospholipase inhibitor activity|calcium ion binding|calcium-dependent phospholipid binding|nucleus|cytoplasm|plasma membrane|regulation of transcription from RNA polymerase II promoter|signal transduction|Notch signaling pathway|cell surface|vesicle membrane|epithelial cell differentiation|nuclear membrane|negative regulation of NF-kappaB transcription factor activity|identical protein binding|negative regulation of apoptotic process|calcium-dependent protein binding|perinuclear region of cytoplasm|NF-kappaB binding|extracellular exosome|negative regulation of interleukin-8 secretion ANXA5 14281.3068870818 13675.2950996118 14887.3186745518 1.08862869620813 0.122511971059444 0.34367086537564 1 141.35 149.553 159.167 163.976 GeneID:308,Genbank:NM_001154.3,HGNC:HGNC:543,MIM:131230 annexin A5 GO:0002576,GO:0004859,GO:0005509,GO:0005543,GO:0005544,GO:0005576,GO:0005622,GO:0005737,GO:0005829,GO:0005925,GO:0007165,GO:0007596,GO:0009897,GO:0010033,GO:0016020,GO:0043066,GO:0050819,GO:0070062,GO:0072563 platelet degranulation|phospholipase inhibitor activity|calcium ion binding|phospholipid binding|calcium-dependent phospholipid binding|extracellular region|intracellular|cytoplasm|cytosol|focal adhesion|signal transduction|blood coagulation|external side of plasma membrane|response to organic substance|membrane|negative regulation of apoptotic process|negative regulation of coagulation|extracellular exosome|endothelial microparticle ANXA6 2730.54534620382 2368.34791011019 3092.74278229745 1.30586505854773 0.385005823819844 0.0053349371654025 0.285941071095182 19.5475 20.6472 25.9945 27.6621 GeneID:309,Genbank:NM_001155.4,HGNC:HGNC:544,MIM:114070 annexin A6 GO:0005509,GO:0005525,GO:0005544,GO:0005739,GO:0005765,GO:0005925,GO:0006816,GO:0006937,GO:0008289,GO:0015276,GO:0015485,GO:0016020,GO:0031902,GO:0034220,GO:0042470,GO:0042803,GO:0048306,GO:0048471,GO:0051260,GO:0051560,GO:0070062,GO:0097190 calcium ion binding|GTP binding|calcium-dependent phospholipid binding|mitochondrion|lysosomal membrane|focal adhesion|calcium ion transport|regulation of muscle contraction|lipid binding|ligand-gated ion channel activity|cholesterol binding|membrane|late endosome membrane|ion transmembrane transport|melanosome|protein homodimerization activity|calcium-dependent protein binding|perinuclear region of cytoplasm|protein homooligomerization|mitochondrial calcium ion homeostasis|extracellular exosome|apoptotic signaling pathway ANXA7 3469.08823021745 3197.26187586877 3740.91458456612 1.17003696594281 0.226554110782962 0.0924574602265957 0.987199121992771 27.3946 27.9566 34.9263 31.6122 GeneID:310,Genbank:NM_001320879.1,HGNC:HGNC:545,MIM:186360 annexin A7 GO:0003723,GO:0005178,GO:0005509,GO:0005544,GO:0005634,GO:0005635,GO:0005789,GO:0005829,GO:0005886,GO:0006874,GO:0006914,GO:0007599,GO:0008283,GO:0008360,GO:0009651,GO:0009992,GO:0010629,GO:0014070,GO:0016020,GO:0030855,GO:0035176,GO:0048306,GO:0051592,GO:0061025,GO:0070062 RNA binding|integrin binding|calcium ion binding|calcium-dependent phospholipid binding|nucleus|nuclear envelope|endoplasmic reticulum membrane|cytosol|plasma membrane|cellular calcium ion homeostasis|autophagy|hemostasis|cell proliferation|regulation of cell shape|response to salt stress|cellular water homeostasis|negative regulation of gene expression|response to organic cyclic compound|membrane|epithelial cell differentiation|social behavior|calcium-dependent protein binding|response to calcium ion|membrane fusion|extracellular exosome ANXA8 6.60018342807664 11.2618335899114 1.93853326624189 0.172133005763686 -2.53840434041397 0.0427914526282893 0.771788181638154 0.0584516 0.0435032 0.0182509 0.00852487 GeneID:653145,Genbank:XM_006717951.3,HGNC:HGNC:546,MIM:602396 annexin A8 GO:0005509,GO:0005544,GO:0005546,GO:0005547,GO:0005829,GO:0005886,GO:0007032,GO:0007596,GO:0016197,GO:0031902,GO:0043325,GO:0051015,GO:1900004,GO:1900138 calcium ion binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|plasma membrane|endosome organization|blood coagulation|endosomal transport|late endosome membrane|phosphatidylinositol-3,4-bisphosphate binding|actin filament binding|negative regulation of serine-type endopeptidase activity|negative regulation of phospholipase A2 activity ANXA9 25.4468261229048 24.7338928161849 26.1597594296247 1.05764828949638 0.080859953201169 0.971900202256083 1 0.197543 0.351959 0.167107 0.29649 GeneID:8416,Genbank:NM_003568.2,HGNC:HGNC:547,MIM:603319 annexin A9 GO:0001786,GO:0005509,GO:0005543,GO:0005544,GO:0005829,GO:0009986,GO:0015464,GO:0042803,GO:0070062,GO:0098609 phosphatidylserine binding|calcium ion binding|phospholipid binding|calcium-dependent phospholipid binding|cytosol|cell surface|acetylcholine receptor activity|protein homodimerization activity|extracellular exosome|cell-cell adhesion AOAH 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.0030002 0 GeneID:313,Genbank:XM_017012102.2,HGNC:HGNC:548,MIM:102593 acyloxyacyl hydrolase GO:0003824,GO:0004465,GO:0005576,GO:0006629,GO:0006954,GO:0031410,GO:0050528 catalytic activity|lipoprotein lipase activity|extracellular region|lipid metabolic process|inflammatory response|cytoplasmic vesicle|acyloxyacyl hydrolase activity AOC2 43.4346221790577 43.2409362309789 43.6283081271366 1.00895845302906 0.0128667682569323 1 1 0.449553 0.751474 0.857107 0.392949 GeneID:314,Genbank:NM_009590.3,HGNC:HGNC:549,MIM:602268 amine oxidase, copper containing 2 hsa00260,hsa00350,hsa00360,hsa00410 Glycine, serine and threonine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism AOC3 8.474484529918 7.73528122683997 9.21368783299604 1.19112512690893 0.252324975325381 0.877004086671928 1 0.0666783 0.0592024 0.124801 0.025052 GeneID:8639,Genbank:XM_011525419.2,HGNC:HGNC:550,MIM:603735 amine oxidase, copper containing 3 hsa00260,hsa00350,hsa00360,hsa00410 Glycine, serine and threonine metabolism|Tyrosine metabolism|Phenylalanine metabolism|beta-Alanine metabolism AOX1 33.4546120552995 35.3997937996611 31.5094303109379 0.890102086166377 -0.167957286044398 0.757243614917566 1 0.242087 0.220252 0.274878 0.134364 GeneID:316,Genbank:XM_011511062.1,HGNC:HGNC:553,MIM:602841 aldehyde oxidase 1 GO:0004031,GO:0005506,GO:0005829,GO:0009055,GO:0009115,GO:0016614,GO:0016903,GO:0017144,GO:0042802,GO:0042803,GO:0042816,GO:0043546,GO:0050660,GO:0051287,GO:0051537,GO:0055114,GO:0070062,GO:0102797,GO:0102798 aldehyde oxidase activity|iron ion binding|cytosol|electron transfer activity|xanthine catabolic process|oxidoreductase activity, acting on CH-OH group of donors|oxidoreductase activity, acting on the aldehyde or oxo group of donors|drug metabolic process|identical protein binding|protein homodimerization activity|vitamin B6 metabolic process|molybdopterin cofactor binding|flavin adenine dinucleotide binding|NAD binding|2 iron, 2 sulfur cluster binding|oxidation-reduction process|extracellular exosome|geranial:oxygen oxidoreductase activity|heptaldehyde:oxygen oxidoreductase activity hsa00280,hsa00350,hsa00380,hsa00750,hsa00760,hsa00830,hsa00982,hsa04630 Valine, leucine and isoleucine degradation|Tyrosine metabolism|Tryptophan metabolism|Vitamin B6 metabolism|Nicotinate and nicotinamide metabolism|Retinol metabolism|Drug metabolism - cytochrome P450|Jak-STAT signaling pathway AP1AR 268.080532977255 286.071135224132 250.089930730378 0.874222876538861 -0.193926964032892 0.362465454204688 1 1.71997 1.61891 1.73752 1.33903 GeneID:55435,Genbank:NM_018569.5,HGNC:HGNC:28808,MIM:610851 adaptor related protein complex 1 associated regulatory protein GO:0001920,GO:0005768,GO:0005769,GO:0005770,GO:0005794,GO:0005829,GO:0015031,GO:0019894,GO:0030133,GO:0034315,GO:0034613,GO:0035650,GO:0048203,GO:1900025,GO:2000146 negative regulation of receptor recycling|endosome|early endosome|late endosome|Golgi apparatus|cytosol|protein transport|kinesin binding|transport vesicle|regulation of Arp2/3 complex-mediated actin nucleation|cellular protein localization|AP-1 adaptor complex binding|vesicle targeting, trans-Golgi to endosome|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of cell motility AP1B1 4150.14497225576 3839.81276606633 4460.47717844519 1.1616392387316 0.216162091717121 0.108932179177934 1 28.1718 28.4879 35.0746 33.5125 GeneID:162,Genbank:NM_001166019.1,HGNC:HGNC:554,MIM:600157 adaptor related protein complex 1 beta 1 subunit GO:0000139,GO:0005215,GO:0005765,GO:0005794,GO:0005829,GO:0006886,GO:0007368,GO:0007507,GO:0016192,GO:0019886,GO:0019901,GO:0030131,GO:0030276,GO:0030659,GO:0030665,GO:0032588,GO:0043231,GO:0050690 Golgi membrane|transporter activity|lysosomal membrane|Golgi apparatus|cytosol|intracellular protein transport|determination of left/right symmetry|heart development|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|clathrin adaptor complex|clathrin binding|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|regulation of defense response to virus by virus hsa04142,hsa05170 Lysosome|Human immunodeficiency virus 1 infection AP1G1 2072.00900543822 2081.70620024153 2062.3118106349 0.990683416514598 -0.0135039924641666 0.95071651951431 1 11.7788 11.4817 13.292 9.996 GeneID:164,Genbank:NM_001128.5,HGNC:HGNC:555,MIM:603533 adaptor related protein complex 1 gamma 1 subunit GO:0000139,GO:0005215,GO:0005737,GO:0005765,GO:0005794,GO:0005829,GO:0006886,GO:0008565,GO:0016020,GO:0017137,GO:0019886,GO:0019894,GO:0030119,GO:0030131,GO:0030136,GO:0030659,GO:0030665,GO:0030742,GO:0032438,GO:0032588,GO:0035646,GO:0043231,GO:0043323,GO:0045954,GO:0050690,GO:0055037,GO:0090160 Golgi membrane|transporter activity|cytoplasm|lysosomal membrane|Golgi apparatus|cytosol|intracellular protein transport|protein transporter activity|membrane|Rab GTPase binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|kinesin binding|AP-type membrane coat adaptor complex|clathrin adaptor complex|clathrin-coated vesicle|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|GTP-dependent protein binding|melanosome organization|trans-Golgi network membrane|endosome to melanosome transport|intracellular membrane-bounded organelle|positive regulation of natural killer cell degranulation|positive regulation of natural killer cell mediated cytotoxicity|regulation of defense response to virus by virus|recycling endosome|Golgi to lysosome transport hsa04142,hsa05170 Lysosome|Human immunodeficiency virus 1 infection AP1G2 623.642208407202 683.205165248099 564.079251566306 0.8256366904976 -0.276421010726524 0.0921294296685288 0.985009977016794 2.54134 2.70542 1.90891 2.00016 GeneID:8906,Genbank:NM_001282474.1,HGNC:HGNC:556,MIM:603534 adaptor related protein complex 1 gamma 2 subunit GO:0000139,GO:0005794,GO:0005798,GO:0006886,GO:0008565,GO:0010008,GO:0016020,GO:0016032,GO:0016192,GO:0030121,GO:0030133 Golgi membrane|Golgi apparatus|Golgi-associated vesicle|intracellular protein transport|protein transporter activity|endosome membrane|membrane|viral process|vesicle-mediated transport|AP-1 adaptor complex|transport vesicle hsa04142,hsa05170 Lysosome|Human immunodeficiency virus 1 infection AP1M1 3227.94398318457 3075.1529378914 3380.73502847774 1.09937134729822 0.136678784297803 0.323868913831375 1 46.8965 47.8867 53.7479 52.2808 GeneID:8907,Genbank:NM_001130524.1,HGNC:HGNC:13667,MIM:603535 adaptor related protein complex 1 mu 1 subunit GO:0000139,GO:0005765,GO:0005829,GO:0005886,GO:0006886,GO:0016020,GO:0019886,GO:0030131,GO:0030659,GO:0030665,GO:0032438,GO:0032588,GO:0035579,GO:0035646,GO:0043312,GO:0050690,GO:0070062 Golgi membrane|lysosomal membrane|cytosol|plasma membrane|intracellular protein transport|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|clathrin adaptor complex|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|melanosome organization|trans-Golgi network membrane|specific granule membrane|endosome to melanosome transport|neutrophil degranulation|regulation of defense response to virus by virus|extracellular exosome hsa04142,hsa05170 Lysosome|Human immunodeficiency virus 1 infection AP1M2 79.7615171275869 82.9553200988863 76.5677141562875 0.922999441928685 -0.115598319309879 0.712966779665924 1 1.08438 1.61397 1.32033 1.40958 GeneID:10053,Genbank:NM_005498.4,HGNC:HGNC:558,MIM:607309 adaptor related protein complex 1 mu 2 subunit GO:0000139,GO:0005765,GO:0005829,GO:0006605,GO:0006903,GO:0019886,GO:0030131,GO:0030659,GO:0030665,GO:0032588,GO:0043231,GO:0050690 Golgi membrane|lysosomal membrane|cytosol|protein targeting|vesicle targeting|antigen processing and presentation of exogenous peptide antigen via MHC class II|clathrin adaptor complex|cytoplasmic vesicle membrane|clathrin-coated vesicle membrane|trans-Golgi network membrane|intracellular membrane-bounded organelle|regulation of defense response to virus by virus hsa04142,hsa05170 Lysosome|Human immunodeficiency virus 1 infection AP1S1 3022.33307710092 3017.91267041347 3026.75348378836 1.00292944638908 0.0042201194847372 0.999266909996188 1 99.0587 107.705 98.0409 111.229 GeneID:1174,Genbank:NM_001283.4,HGNC:HGNC:559,MIM:603531 adaptor related protein complex 1 sigma 1 subunit GO:0000139,GO:0005765,GO:0005794,GO:0005829,GO:0005905,GO:0006886,GO:0006898,GO:0008565,GO:0009615,GO:0016020,GO:0019886,GO:0030121,GO:0030659,GO:0032588,GO:0042147,GO:0043195,GO:0043231,GO:0050690,GO:0070062 Golgi membrane|lysosomal membrane|Golgi apparatus|cytosol|clathrin-coated pit|intracellular protein transport|receptor-mediated endocytosis|protein transporter activity|response to virus|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|AP-1 adaptor complex|cytoplasmic vesicle membrane|trans-Golgi network membrane|retrograde transport, endosome to Golgi|terminal bouton|intracellular membrane-bounded organelle|regulation of defense response to virus by virus|extracellular exosome hsa04142,hsa05170 Lysosome|Human immunodeficiency virus 1 infection AP1S2 722.898777877307 698.943251038817 746.854304715796 1.06854784505862 0.0956515072335115 0.535630922319823 1 5.81008 5.66106 6.75263 5.33568 GeneID:8905,Genbank:NM_003916.4,HGNC:HGNC:560,MIM:300629 adaptor related protein complex 1 sigma 2 subunit GO:0005794,GO:0005905,GO:0006886,GO:0008542,GO:0008565,GO:0016192,GO:0030117,GO:0030659,GO:0036465,GO:0043231,GO:0045444,GO:0050885,GO:0060612,GO:0098793 Golgi apparatus|clathrin-coated pit|intracellular protein transport|visual learning|protein transporter activity|vesicle-mediated transport|membrane coat|cytoplasmic vesicle membrane|synaptic vesicle recycling|intracellular membrane-bounded organelle|fat cell differentiation|neuromuscular process controlling balance|adipose tissue development|presynapse hsa04142,hsa05170 Lysosome|Human immunodeficiency virus 1 infection AP1S3 285.189157532738 309.622971482554 260.755343582922 0.842170535132966 -0.247815693805867 0.230617759694144 1 3.75111 3.62298 3.44687 2.68364 GeneID:130340,Genbank:NM_001039569.1,HGNC:HGNC:18971,MIM:615781 adaptor related protein complex 1 sigma 3 subunit GO:0005794,GO:0005905,GO:0006605,GO:0008565,GO:0016192,GO:0030117,GO:0030659,GO:0043231 Golgi apparatus|clathrin-coated pit|protein targeting|protein transporter activity|vesicle-mediated transport|membrane coat|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle hsa04142,hsa05170 Lysosome|Human immunodeficiency virus 1 infection AP2A1 3339.24094779512 3465.84062145162 3212.64127413861 0.926944318862833 -0.109445415489775 0.652458788153353 1 26.002 28.3813 22.1877 29.0562 GeneID:160,Genbank:NM_014203.2,HGNC:HGNC:561,MIM:601026 adaptor related protein complex 2 alpha 1 subunit GO:0005829,GO:0005886,GO:0006886,GO:0006895,GO:0006897,GO:0007018,GO:0008022,GO:0008565,GO:0010976,GO:0016020,GO:0016323,GO:0016324,GO:0019886,GO:0019901,GO:0030122,GO:0030130,GO:0030666,GO:0030669,GO:0032403,GO:0032433,GO:0032802,GO:0034383,GO:0036020,GO:0045334,GO:0048013,GO:0048260,GO:0050690,GO:0050750,GO:0060071,GO:0061024,GO:0072583,GO:1900126 cytosol|plasma membrane|intracellular protein transport|Golgi to endosome transport|endocytosis|microtubule-based movement|protein C-terminus binding|protein transporter activity|positive regulation of neuron projection development|membrane|basolateral plasma membrane|apical plasma membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|protein complex binding|filopodium tip|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|endolysosome membrane|clathrin-coated endocytic vesicle|ephrin receptor signaling pathway|positive regulation of receptor-mediated endocytosis|regulation of defense response to virus by virus|low-density lipoprotein particle receptor binding|Wnt signaling pathway, planar cell polarity pathway|membrane organization|clathrin-dependent endocytosis|negative regulation of hyaluronan biosynthetic process hsa04144,hsa04721,hsa04961,hsa05016 Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2A2 2405.53650166279 2408.82090571795 2402.25209760764 0.997273019303876 -0.00393957554482628 0.96811123215852 1 18.8642 18.9756 19.3791 19.3787 GeneID:161,Genbank:NM_001242837.1,HGNC:HGNC:562,MIM:607242 adaptor related protein complex 2 alpha 2 subunit GO:0005829,GO:0005886,GO:0006886,GO:0007018,GO:0008289,GO:0008565,GO:0019886,GO:0019901,GO:0030122,GO:0030666,GO:0030667,GO:0030669,GO:0031410,GO:0032802,GO:0034383,GO:0036020,GO:0043312,GO:0045334,GO:0048013,GO:0050690,GO:0060071,GO:0061024,GO:0072583,GO:0097718,GO:0101003 cytosol|plasma membrane|intracellular protein transport|microtubule-based movement|lipid binding|protein transporter activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|AP-2 adaptor complex|endocytic vesicle membrane|secretory granule membrane|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|endolysosome membrane|neutrophil degranulation|clathrin-coated endocytic vesicle|ephrin receptor signaling pathway|regulation of defense response to virus by virus|Wnt signaling pathway, planar cell polarity pathway|membrane organization|clathrin-dependent endocytosis|disordered domain specific binding|ficolin-1-rich granule membrane hsa04144,hsa04721,hsa04961,hsa05016 Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2B1 15880.8761106887 15081.6058170695 16680.1464043078 1.10599273092186 0.145341903567695 0.256970235258419 1 77.9001 78.1677 93.1509 81.3426 GeneID:163,Genbank:NM_001030006.1,HGNC:HGNC:563,MIM:601025 adaptor related protein complex 2 beta 1 subunit GO:0005794,GO:0006886,GO:0016192,GO:0030131,GO:0030276,GO:0030665 Golgi apparatus|intracellular protein transport|vesicle-mediated transport|clathrin adaptor complex|clathrin binding|clathrin-coated vesicle membrane hsa04144,hsa04721,hsa04961,hsa05016 Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2M1 21283.1858054139 20518.9745569243 22047.3970539035 1.07448824953406 0.103649705723695 0.434437448683308 1 291.759 301.621 318.511 328.657 GeneID:1173,Genbank:NM_001311198.1,HGNC:HGNC:564,MIM:601024 adaptor related protein complex 2 mu 1 subunit GO:0005886,GO:0005905,GO:0006886,GO:0006897,GO:0008289,GO:0030131 plasma membrane|clathrin-coated pit|intracellular protein transport|endocytosis|lipid binding|clathrin adaptor complex hsa04144,hsa04721,hsa04961,hsa05016 Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP2S1 3728.22921041304 3756.49488708189 3699.9635337442 0.984951036794407 -0.0218760867951448 0.850055682965771 1 52.0542 56.803 54.5866 57.7861 GeneID:1175,Genbank:NM_021575.3,HGNC:HGNC:565,MIM:602242 adaptor related protein complex 2 sigma 1 subunit GO:0005886,GO:0006886,GO:0006897,GO:0008565,GO:0030122 plasma membrane|intracellular protein transport|endocytosis|protein transporter activity|AP-2 adaptor complex hsa04144,hsa04721,hsa04961,hsa05016 Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease AP3B1 1456.27332245904 1418.32338813408 1494.22325678399 1.05351379613768 0.0752092068833584 0.697706684186182 1 7.072 5.83853 7.56516 6.14281 GeneID:8546,Genbank:NM_003664.4,HGNC:HGNC:566,MIM:603401 adaptor related protein complex 3 beta 1 subunit hsa04142 Lysosome AP3B2 139.856741233696 127.550800676152 152.16268179124 1.19295748034995 0.254542623098981 0.335453136084996 1 0.405389 0.457486 0.456014 0.492959 GeneID:8120,Genbank:NM_001278511.1,HGNC:HGNC:567,MIM:602166 adaptor related protein complex 3 beta 2 subunit GO:0005215,GO:0005794,GO:0006886,GO:0006892,GO:0008089,GO:0030123,GO:0030131,GO:0030137,GO:0030665,GO:0048490,GO:1904115 transporter activity|Golgi apparatus|intracellular protein transport|post-Golgi vesicle-mediated transport|anterograde axonal transport|AP-3 adaptor complex|clathrin adaptor complex|COPI-coated vesicle|clathrin-coated vesicle membrane|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP3D1 5803.55760533894 5421.72496690566 6185.39024377223 1.14085282479801 0.190112689409979 0.153372373240007 1 32.5095 32.2537 39.108 36.1134 GeneID:8943,Genbank:NM_003938.7,HGNC:HGNC:568,MIM:607246 adaptor related protein complex 3 delta 1 subunit GO:0000139,GO:0005215,GO:0005765,GO:0005794,GO:0005886,GO:0006726,GO:0006886,GO:0008089,GO:0010008,GO:0016020,GO:0016182,GO:0030123,GO:0032438,GO:0035646,GO:0043195,GO:0048007,GO:0048490,GO:0048499,GO:0051138,GO:0061088,GO:0072657,GO:0098830,GO:0098943,GO:1904115 Golgi membrane|transporter activity|lysosomal membrane|Golgi apparatus|plasma membrane|eye pigment biosynthetic process|intracellular protein transport|anterograde axonal transport|endosome membrane|membrane|synaptic vesicle budding from endosome|AP-3 adaptor complex|melanosome organization|endosome to melanosome transport|terminal bouton|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|anterograde synaptic vesicle transport|synaptic vesicle membrane organization|positive regulation of NK T cell differentiation|regulation of sequestering of zinc ion|protein localization to membrane|presynaptic endosome|neurotransmitter receptor transport, postsynaptic endosome to lysosome|axon cytoplasm hsa04142 Lysosome AP3M1 1318.89560169839 1319.98578347749 1317.80541991929 0.998348191635479 -0.00238502608174686 0.988175958913689 1 9.90396 8.6729 10.3107 8.47258 GeneID:26985,Genbank:XM_024447939.1,HGNC:HGNC:569,MIM:610366 adaptor related protein complex 3 mu 1 subunit GO:0005764,GO:0005765,GO:0005794,GO:0006622,GO:0008089,GO:0017137,GO:0030131,GO:0030659,GO:0048490,GO:1904115 lysosome|lysosomal membrane|Golgi apparatus|protein targeting to lysosome|anterograde axonal transport|Rab GTPase binding|clathrin adaptor complex|cytoplasmic vesicle membrane|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP3M2 749.78276609218 777.449710900511 722.11582128385 0.928826406594752 -0.106519106187603 0.518459548565419 1 6.46792 6.16285 6.27425 5.60899 GeneID:10947,Genbank:NM_001134296.1,HGNC:HGNC:570,MIM:610469 adaptor related protein complex 3 mu 2 subunit GO:0005794,GO:0006886,GO:0008089,GO:0030119,GO:0030131,GO:0030659,GO:0048490,GO:1904115 Golgi apparatus|intracellular protein transport|anterograde axonal transport|AP-type membrane coat adaptor complex|clathrin adaptor complex|cytoplasmic vesicle membrane|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP3S1 1539.7088093159 1535.88268967405 1543.53492895774 1.00498230713526 0.00717010276449548 0.943249662228456 1 6.05396 5.92436 6.10329 6.08711 GeneID:1176,Genbank:NM_001002924.2,HGNC:HGNC:2013,MIM:601507 adaptor related protein complex 3 sigma 1 subunit GO:0005215,GO:0005794,GO:0006886,GO:0008089,GO:0008286,GO:0008565,GO:0030119,GO:0030123,GO:0030133,GO:0030659,GO:0043231,GO:0048490,GO:1904115 transporter activity|Golgi apparatus|intracellular protein transport|anterograde axonal transport|insulin receptor signaling pathway|protein transporter activity|AP-type membrane coat adaptor complex|AP-3 adaptor complex|transport vesicle|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP3S2 8.1720695946172 6.169014471598 10.1751247176364 1.64939225940909 0.721934542138812 0.508045534597591 1 11.0455 11.4661 11.777 11.0427 GeneID:10239,Genbank:NM_005829.4,HGNC:HGNC:571,MIM:602416 adaptor related protein complex 3 sigma 2 subunit GO:0005794,GO:0006886,GO:0008089,GO:0008565,GO:0030123,GO:0030659,GO:0043231,GO:0048490,GO:1904115 Golgi apparatus|intracellular protein transport|anterograde axonal transport|protein transporter activity|AP-3 adaptor complex|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle|anterograde synaptic vesicle transport|axon cytoplasm hsa04142 Lysosome AP4B1 322.226640646737 334.308838024054 310.14444326942 0.927718349004894 -0.108241218595505 0.591352284597296 1 3.1121 2.91933 2.56432 2.94053 GeneID:10717,Genbank:NM_001253853.2,HGNC:HGNC:572,MIM:607245 adaptor related protein complex 4 beta 1 subunit GO:0005802,GO:0005829,GO:0006605,GO:0008104,GO:0016192,GO:0019898,GO:0030124,GO:0030131,GO:0030276,GO:0031904,GO:0032588 trans-Golgi network|cytosol|protein targeting|protein localization|vesicle-mediated transport|extrinsic component of membrane|AP-4 adaptor complex|clathrin adaptor complex|clathrin binding|endosome lumen|trans-Golgi network membrane hsa04142 Lysosome AP4E1 275.905644832919 299.263828456549 252.54746120929 0.843895710723883 -0.244863374293673 0.567612003089799 1 1.94732 1.45119 1.92773 1.10894 GeneID:23431,Genbank:XM_005254264.4,HGNC:HGNC:573,MIM:607244 adaptor related protein complex 4 epsilon 1 subunit GO:0006605,GO:0008104,GO:0016192,GO:0030124,GO:0031904,GO:0032588 protein targeting|protein localization|vesicle-mediated transport|AP-4 adaptor complex|endosome lumen|trans-Golgi network membrane hsa04142 Lysosome AP4M1 490.242963851636 508.502665780417 471.983261922856 0.928182473140993 -0.107519639515981 0.549465030889489 1 9.12101 9.62213 7.66039 9.37764 GeneID:9179,Genbank:XM_005250689.4,HGNC:HGNC:574,MIM:602296 adaptor related protein complex 4 mu 1 subunit GO:0005769,GO:0005802,GO:0005829,GO:0006605,GO:0006622,GO:0006886,GO:0006895,GO:0008104,GO:0019904,GO:0030124,GO:0030131,GO:0031904,GO:0032588,GO:0070062,GO:0090160,GO:1903361 early endosome|trans-Golgi network|cytosol|protein targeting|protein targeting to lysosome|intracellular protein transport|Golgi to endosome transport|protein localization|protein domain specific binding|AP-4 adaptor complex|clathrin adaptor complex|endosome lumen|trans-Golgi network membrane|extracellular exosome|Golgi to lysosome transport|protein localization to basolateral plasma membrane hsa04142 Lysosome AP4S1 112.693623500644 107.131497928213 118.255749073075 1.10383735278598 0.14252761086993 0.628646115599823 1 0.479267 0.510348 0.684229 0.53256 GeneID:11154,Genbank:NM_001254729.1,HGNC:HGNC:575,MIM:607243 adaptor related protein complex 4 sigma 1 subunit GO:0006605,GO:0008104,GO:0008565,GO:0016192,GO:0030124,GO:0031904,GO:0032588,GO:0043231 protein targeting|protein localization|protein transporter activity|vesicle-mediated transport|AP-4 adaptor complex|endosome lumen|trans-Golgi network membrane|intracellular membrane-bounded organelle hsa04142 Lysosome AP5B1 898.588840483532 850.192000799156 946.985680167909 1.11384920027214 0.155553925006438 0.333134161820232 1 5.61221 6.2591 7.08019 6.43211 GeneID:91056,Genbank:NM_138368.4,HGNC:HGNC:25104,MIM:614367 adaptor related protein complex 5 beta 1 subunit GO:0005765,GO:0015031,GO:0016197,GO:0030119 lysosomal membrane|protein transport|endosomal transport|AP-type membrane coat adaptor complex AP5M1 437.441197953838 436.712109721218 438.170286186457 1.00333898793457 0.00480911700352978 0.972991758256733 1 1.74855 1.57267 2.02084 1.32946 GeneID:55745,Genbank:NM_018229.3,HGNC:HGNC:20192,MIM:614368 adaptor related protein complex 5 mu 1 subunit GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0015031,GO:0016020,GO:0016197,GO:0030119,GO:0031902 lysosome|lysosomal membrane|late endosome|cytosol|protein transport|membrane|endosomal transport|AP-type membrane coat adaptor complex|late endosome membrane AP5S1 514.62959847719 490.850286654844 538.408910299536 1.0968902839373 0.133419227896443 0.444101943678293 1 10.9406 10.4678 12.2758 12.1606 GeneID:55317,Genbank:NM_001204446.1,HGNC:HGNC:15875,MIM:614824 adaptor related protein complex 5 sigma 1 subunit GO:0000724,GO:0005654,GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0015031,GO:0016197,GO:0030119,GO:0031902 double-strand break repair via homologous recombination|nucleoplasm|lysosome|lysosomal membrane|late endosome|cytosol|protein transport|endosomal transport|AP-type membrane coat adaptor complex|late endosome membrane AP5Z1 1003.15935290509 876.683248468468 1129.63545734171 1.2885331838097 0.365729691641645 0.0168154429249528 0.538760869736292 8.20888 8.01718 10.4747 10.723 GeneID:9907,Genbank:XM_017012864.1,HGNC:HGNC:22197,MIM:613653 adaptor related protein complex 5 zeta 1 subunit GO:0000724,GO:0005634,GO:0005654,GO:0005737,GO:0015031,GO:0016197,GO:0016607,GO:0030119,GO:0044599 double-strand break repair via homologous recombination|nucleus|nucleoplasm|cytoplasm|protein transport|endosomal transport|nuclear speck|AP-type membrane coat adaptor complex|AP-5 adaptor complex APAF1 297.671719475333 331.666375915528 263.677063035139 0.79500691713861 -0.330960681939229 0.103973743792489 1 1.84076 1.75718 1.72956 1.15918 GeneID:317,Genbank:XM_017019250.1,HGNC:HGNC:576,MIM:602233 apoptotic peptidase activating factor 1 hsa01524,hsa04115,hsa04210,hsa04215,hsa05010,hsa05012,hsa05014,hsa05016,hsa05134,hsa05152,hsa05161,hsa05169,hsa05200,hsa05222 Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis (ALS)|Huntington disease|Legionellosis|Tuberculosis|Hepatitis B|Epstein-Barr virus infection|Pathways in cancer|Small cell lung cancer APBA1 140.582081371696 129.463060009296 151.701102734095 1.17177133557018 0.228691063595314 0.391044336353133 1 0.625797 0.679093 0.867959 0.683386 GeneID:320,Genbank:XM_011518617.2,HGNC:HGNC:578,MIM:602414 amyloid beta precursor protein binding family A member 1 GO:0001540,GO:0001701,GO:0005634,GO:0005794,GO:0005829,GO:0006461,GO:0006886,GO:0007155,GO:0007268,GO:0007269,GO:0007399,GO:0007626,GO:0008021,GO:0008088,GO:0010468,GO:0014047,GO:0014051,GO:0016020,GO:0035264,GO:0043005,GO:0048471 amyloid-beta binding|in utero embryonic development|nucleus|Golgi apparatus|cytosol|protein complex assembly|intracellular protein transport|cell adhesion|chemical synaptic transmission|neurotransmitter secretion|nervous system development|locomotory behavior|synaptic vesicle|axo-dendritic transport|regulation of gene expression|glutamate secretion|gamma-aminobutyric acid secretion|membrane|multicellular organism growth|neuron projection|perinuclear region of cytoplasm APBA2 2097.82729731753 1898.04240471798 2297.61218991709 1.21051678519189 0.27562308408299 0.052685150212717 0.839722270863765 7.39735 8.31863 10.0482 9.79285 GeneID:321,Genbank:XM_011521489.2,HGNC:HGNC:579,MIM:602712 amyloid beta precursor protein binding family A member 2 GO:0001540,GO:0001701,GO:0005886,GO:0007268,GO:0007399,GO:0007626,GO:0008021,GO:0010468,GO:0015031,GO:0035264 amyloid-beta binding|in utero embryonic development|plasma membrane|chemical synaptic transmission|nervous system development|locomotory behavior|synaptic vesicle|regulation of gene expression|protein transport|multicellular organism growth APBA3 472.342463813958 492.061769177931 452.623158449985 0.919850284662769 -0.12052902844731 0.477972540009247 1 7.99023 8.78333 7.74353 7.36258 GeneID:9546,Genbank:NM_004886.3,HGNC:HGNC:580,MIM:604262 amyloid beta precursor protein binding family A member 3 GO:0001540,GO:0001701,GO:0004857,GO:0007268,GO:0010468,GO:0015031,GO:0019899,GO:0043086,GO:0048471 amyloid-beta binding|in utero embryonic development|enzyme inhibitor activity|chemical synaptic transmission|regulation of gene expression|protein transport|enzyme binding|negative regulation of catalytic activity|perinuclear region of cytoplasm APBB1 899.618179175141 811.583238249857 987.653120100425 1.21694617822598 0.283265363513001 0.0754869981662081 0.94157495521624 5.49394 5.82017 7.1031 7.19029 GeneID:322,Genbank:NM_145689.2,HGNC:HGNC:581,MIM:602709 amyloid beta precursor protein binding family B member 1 GO:0000122,GO:0001540,GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006302,GO:0006351,GO:0006355,GO:0006915,GO:0006974,GO:0007050,GO:0007165,GO:0007409,GO:0008134,GO:0010039,GO:0010976,GO:0016607,GO:0030027,GO:0030308,GO:0030426,GO:0032403,GO:0042393,GO:0042734,GO:0043025,GO:0043065,GO:0043197,GO:0043234,GO:0043967,GO:0044304,GO:0045202,GO:0045211,GO:0045739,GO:0045893,GO:0045944,GO:0048156,GO:0048471,GO:0050714,GO:0050760,GO:0070064,GO:1990761,GO:1990812 negative regulation of transcription from RNA polymerase II promoter|amyloid-beta binding|chromatin binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|double-strand break repair|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|cellular response to DNA damage stimulus|cell cycle arrest|signal transduction|axonogenesis|transcription factor binding|response to iron ion|positive regulation of neuron projection development|nuclear speck|lamellipodium|negative regulation of cell growth|growth cone|protein complex binding|histone binding|presynaptic membrane|neuronal cell body|positive regulation of apoptotic process|dendritic spine|protein complex|histone H4 acetylation|main axon|synapse|postsynaptic membrane|positive regulation of DNA repair|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|tau protein binding|perinuclear region of cytoplasm|positive regulation of protein secretion|negative regulation of thymidylate synthase biosynthetic process|proline-rich region binding|growth cone lamellipodium|growth cone filopodium hsa05010 Alzheimer disease APBB2 2074.016770373 2073.57588316125 2074.45765758475 1.00042524338302 0.00061336611415586 0.980539140353406 1 6.77668 6.05259 7.53403 5.42939 GeneID:323,Genbank:NM_001330658.1,HGNC:HGNC:582,MIM:602710 amyloid beta precursor protein binding family B member 2 GO:0001540,GO:0001764,GO:0005634,GO:0005737,GO:0006355,GO:0007050,GO:0007411,GO:0008134,GO:0016020,GO:0030027,GO:0030198,GO:0030308,GO:0030426,GO:0035556,GO:0043065,GO:0043066,GO:0045202 amyloid-beta binding|neuron migration|nucleus|cytoplasm|regulation of transcription, DNA-templated|cell cycle arrest|axon guidance|transcription factor binding|membrane|lamellipodium|extracellular matrix organization|negative regulation of cell growth|growth cone|intracellular signal transduction|positive regulation of apoptotic process|negative regulation of apoptotic process|synapse APBB3 168.264771562814 166.919191966156 169.610351159471 1.016122527084 0.0230743770690937 0.946216413594878 1 2.44245 2.52696 2.69677 2.67671 GeneID:10307,Genbank:NM_133174.2,HGNC:HGNC:20708,MIM:602711 amyloid beta precursor protein binding family B member 3 GO:0001540,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0008134,GO:0015629 amyloid-beta binding|nucleus|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription factor binding|actin cytoskeleton APC 196.718321501578 191.296266548476 202.14037645468 1.05668751461731 0.0795488036229928 0.866591813906851 1 0.627895 0.371656 0.658952 0.38191 GeneID:324,Genbank:NM_001354895.1,HGNC:HGNC:583,MIM:611731 APC, WNT signaling pathway regulator hsa04310,hsa04390,hsa04550,hsa04810,hsa04934,hsa05165,hsa05166,hsa05200,hsa05206,hsa05210,hsa05213,hsa05217,hsa05224,hsa05225,hsa05226 Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer|Endometrial cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer APC2 185.593390510035 176.374627427401 194.812153592669 1.10453615939094 0.143440649222907 0.560908935771233 1 0.68417 0.762085 0.835064 0.788578 GeneID:10297,Genbank:XM_005259475.2,HGNC:HGNC:24036,MIM:612034 APC2, WNT signaling pathway regulator GO:0000226,GO:0005737,GO:0005794,GO:0005829,GO:0005874,GO:0005884,GO:0008013,GO:0008017,GO:0015630,GO:0016055,GO:0016342,GO:0030496,GO:0031258,GO:0035414,GO:0045171,GO:0048471,GO:0090090,GO:0090630 microtubule cytoskeleton organization|cytoplasm|Golgi apparatus|cytosol|microtubule|actin filament|beta-catenin binding|microtubule binding|microtubule cytoskeleton|Wnt signaling pathway|catenin complex|midbody|lamellipodium membrane|negative regulation of catenin import into nucleus|intercellular bridge|perinuclear region of cytoplasm|negative regulation of canonical Wnt signaling pathway|activation of GTPase activity hsa04310,hsa04390,hsa04550,hsa04810,hsa04934,hsa05165,hsa05166,hsa05200,hsa05206,hsa05210,hsa05213,hsa05217,hsa05224,hsa05225,hsa05226 Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer|Endometrial cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer APCDD1 142.549259253391 123.236210607905 161.862307898877 1.31343139407188 0.393340844539132 0.12714284342927 1 0.50453 0.471662 0.613371 0.618373 GeneID:147495,Genbank:NM_153000.4,HGNC:HGNC:15718,MIM:607479 APC down-regulated 1 GO:0001942,GO:0005887,GO:0016055,GO:0017147,GO:0030178,GO:0042802,GO:0043615 hair follicle development|integral component of plasma membrane|Wnt signaling pathway|Wnt-protein binding|negative regulation of Wnt signaling pathway|identical protein binding|astrocyte cell migration APCDD1L 54.313662832784 43.6829813582513 64.9443443073168 1.48671959394661 0.572132570342663 0.154481980051709 1 0.487516 0.708673 0.958652 0.816256 GeneID:164284,Genbank:NM_153360.2,HGNC:HGNC:26892 APC down-regulated 1 like GO:0016021 integral component of membrane APEH 4559.81087011839 4285.79024015176 4833.83150008502 1.12787402771113 0.173605942075966 0.237519274770655 1 44.6514 45.6693 49.1416 55.1143 GeneID:327,Genbank:XM_011533661.2,HGNC:HGNC:586,MIM:102645 acylaminoacyl-peptide hydrolase GO:0003723,GO:0004252,GO:0005576,GO:0005829,GO:0006415,GO:0006508,GO:0008242,GO:0031965,GO:0042802,GO:0043312,GO:0050435,GO:0070062,GO:1904813 RNA binding|serine-type endopeptidase activity|extracellular region|cytosol|translational termination|proteolysis|omega peptidase activity|nuclear membrane|identical protein binding|neutrophil degranulation|amyloid-beta metabolic process|extracellular exosome|ficolin-1-rich granule lumen APELA 1.02316597922947 1.07619535328461 0.97013660517434 0.901450282435646 -0.149680169798226 1 1 0.0327366 0 0.0314737 0 GeneID:100506013,Genbank:NM_001297550.1,HGNC:HGNC:48925,MIM:615594 apelin receptor early endogenous ligand GO:0001570,GO:0005179,GO:0005576,GO:0005615,GO:0007492,GO:0007507,GO:0007509,GO:0007512,GO:0031704,GO:0035050,GO:0045766,GO:0045823,GO:0060183,GO:0060395,GO:0060674,GO:0060976,GO:0070374,GO:0090133,GO:0090134,GO:1901165,GO:1903589,GO:1904022 vasculogenesis|hormone activity|extracellular region|extracellular space|endoderm development|heart development|mesoderm migration involved in gastrulation|adult heart development|apelin receptor binding|embryonic heart tube development|positive regulation of angiogenesis|positive regulation of heart contraction|apelin receptor signaling pathway|SMAD protein signal transduction|placenta blood vessel development|coronary vasculature development|positive regulation of ERK1 and ERK2 cascade|mesendoderm migration|cell migration involved in mesendoderm migration|positive regulation of trophoblast cell migration|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of G-protein coupled receptor internalization APEX1 3839.08181434674 3939.49815741667 3738.66547127682 0.94902074373058 -0.0754884728146729 0.563628231512676 1 89.4972 94.4578 84.1827 93.1967 GeneID:328,Genbank:NM_001641.3,HGNC:HGNC:587,MIM:107748 apurinic/apyrimidinic endodeoxyribonuclease 1 hsa03410 Base excision repair APEX2 844.238320889155 879.181631752939 809.295010025371 0.920509461067531 -0.119495545104616 0.44454050991469 1 17.6679 18.0432 16.2539 17.2196 GeneID:27301,Genbank:NM_014481.3,HGNC:HGNC:17889,MIM:300773 apurinic/apyrimidinic endodeoxyribonuclease 2 hsa03410 Base excision repair APH1A 3928.64015027275 3780.17895950755 4077.10134103796 1.07854717586415 0.109089281641392 0.423324118839972 1 51.1339 51.9523 57.262 56.5844 GeneID:51107,Genbank:NM_001243771.1,HGNC:HGNC:29509,MIM:607629 aph-1 homolog A, gamma-secretase subunit GO:0001656,GO:0004175,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0006509,GO:0007219,GO:0007220,GO:0016020,GO:0016021,GO:0016485,GO:0031293,GO:0032580,GO:0034205,GO:0035333,GO:0042982,GO:0042987,GO:0043065,GO:0043085,GO:0048013,GO:0070765 metanephros development|endopeptidase activity|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|membrane protein ectodomain proteolysis|Notch signaling pathway|Notch receptor processing|membrane|integral component of membrane|protein processing|membrane protein intracellular domain proteolysis|Golgi cisterna membrane|amyloid-beta formation|Notch receptor processing, ligand-dependent|amyloid precursor protein metabolic process|amyloid precursor protein catabolic process|positive regulation of apoptotic process|positive regulation of catalytic activity|ephrin receptor signaling pathway|gamma-secretase complex hsa04330,hsa05010 Notch signaling pathway|Alzheimer disease APH1B 203.208297190417 158.770274576513 247.646319804321 1.55977761243322 0.641340349401247 0.00432974472541793 0.259719818435557 1.49733 1.21308 2.16451 2.04292 GeneID:83464,Genbank:NM_031301.3,HGNC:HGNC:24080,MIM:607630 aph-1 homolog B, gamma-secretase subunit GO:0004175,GO:0005783,GO:0005886,GO:0005887,GO:0007219,GO:0007220,GO:0008233,GO:0016021,GO:0016485,GO:0030133,GO:0031293,GO:0035333,GO:0043065,GO:0043085,GO:0048013,GO:0070765 endopeptidase activity|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|Notch signaling pathway|Notch receptor processing|peptidase activity|integral component of membrane|protein processing|transport vesicle|membrane protein intracellular domain proteolysis|Notch receptor processing, ligand-dependent|positive regulation of apoptotic process|positive regulation of catalytic activity|ephrin receptor signaling pathway|gamma-secretase complex hsa04330,hsa05010 Notch signaling pathway|Alzheimer disease API5 2452.66464413987 2575.56252489131 2329.76676338844 0.904566183454139 -0.144702032009941 0.311255262396098 1 11.4014 10.3904 10.8893 8.89067 GeneID:8539,Genbank:NM_001142930.1,HGNC:HGNC:594,MIM:609774 apoptosis inhibitor 5 GO:0005634,GO:0005737,GO:0006915,GO:0017134,GO:0043066 nucleus|cytoplasm|apoptotic process|fibroblast growth factor binding|negative regulation of apoptotic process APIP 198.049127363782 208.5360265121 187.562228215463 0.899423621676131 -0.15292732070087 0.504517966659446 1 3.25536 3.47348 3.3135 3.00156 GeneID:51074,Genbank:NM_015957.3,HGNC:HGNC:17581,MIM:612491 APAF1 interacting protein GO:0005737,GO:0006915,GO:0008270,GO:0019509,GO:0042802,GO:0043066,GO:0046570,GO:0051289,GO:0070269,GO:0070372 cytoplasm|apoptotic process|zinc ion binding|L-methionine salvage from methylthioadenosine|identical protein binding|negative regulation of apoptotic process|methylthioribulose 1-phosphate dehydratase activity|protein homotetramerization|pyroptosis|regulation of ERK1 and ERK2 cascade hsa00270 Cysteine and methionine metabolism APLF 30.5182179990559 29.5287456312807 31.5076903668311 1.06701756858422 0.0935839305209794 0.90581979748382 1 0.211454 0.291982 0.317364 0.190655 GeneID:200558,Genbank:NM_173545.2,HGNC:HGNC:28724,MIM:611035 aprataxin and PNKP like factor GO:0000012,GO:0000166,GO:0003906,GO:0004520,GO:0005634,GO:0005654,GO:0005829,GO:0006302,GO:0006974,GO:0008408,GO:0035861,GO:0045191,GO:0046872,GO:0051106,GO:0140078,GO:0140080 single strand break repair|nucleotide binding|DNA-(apurinic or apyrimidinic site) lyase activity|endodeoxyribonuclease activity|nucleus|nucleoplasm|cytosol|double-strand break repair|cellular response to DNA damage stimulus|3'-5' exonuclease activity|site of double-strand break|regulation of isotype switching|metal ion binding|positive regulation of DNA ligation|class I DNA-(apurinic or apyrimidinic site) lyase activity|class III/IV DNA-(apurinic or apyrimidinic site) lyase activity APLN 90.9371029567263 90.2867738180309 91.5874320954218 1.01440585616684 0.0206349792950819 0.966210113752167 1 1.34477 1.30937 1.27922 1.40411 GeneID:8862,Genbank:NM_017413.4,HGNC:HGNC:16665,MIM:300297 apelin GO:0001664,GO:0002026,GO:0005102,GO:0005179,GO:0005576,GO:0005615,GO:0006955,GO:0007165,GO:0007186,GO:0007595,GO:0008284,GO:0023052,GO:0031652,GO:0031704,GO:0042327,GO:0042756,GO:0043576,GO:0045776,GO:0045823,GO:0045906,GO:0048471,GO:0051461,GO:0051466,GO:0060183,GO:0060976,GO:1904022 G-protein coupled receptor binding|regulation of the force of heart contraction|receptor binding|hormone activity|extracellular region|extracellular space|immune response|signal transduction|G-protein coupled receptor signaling pathway|lactation|positive regulation of cell proliferation|signaling|positive regulation of heat generation|apelin receptor binding|positive regulation of phosphorylation|drinking behavior|regulation of respiratory gaseous exchange|negative regulation of blood pressure|positive regulation of heart contraction|negative regulation of vasoconstriction|perinuclear region of cytoplasm|positive regulation of corticotropin secretion|positive regulation of corticotropin-releasing hormone secretion|apelin receptor signaling pathway|coronary vasculature development|positive regulation of G-protein coupled receptor internalization hsa04080,hsa04371 Neuroactive ligand-receptor interaction|Apelin signaling pathway APLP1 932.101454167151 831.473234975406 1032.7296733589 1.24204800577789 0.312720935522372 0.0453140749981235 0.792169711191323 12.4263 13.1799 16.2133 15.7436 GeneID:333,Genbank:NM_001024807.2,HGNC:HGNC:597,MIM:104775 amyloid beta precursor like protein 1 GO:0005604,GO:0005886,GO:0006897,GO:0006915,GO:0007155,GO:0007399,GO:0008201,GO:0009887,GO:0016021,GO:0031694,GO:0031695,GO:0031696,GO:0042802,GO:0046914,GO:0048471,GO:0071874,GO:0106072 basement membrane|plasma membrane|endocytosis|apoptotic process|cell adhesion|nervous system development|heparin binding|animal organ morphogenesis|integral component of membrane|alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|identical protein binding|transition metal ion binding|perinuclear region of cytoplasm|cellular response to norepinephrine stimulus|negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway APLP2 19294.2005415878 19455.747247746 19132.6538354295 0.983393420555773 -0.0241593921218709 0.846749349957913 1 151.185 155.128 155.955 148.943 GeneID:334,Genbank:NM_001642.2,HGNC:HGNC:598,MIM:104776 amyloid beta precursor like protein 2 GO:0002576,GO:0003677,GO:0004867,GO:0005634,GO:0005788,GO:0005886,GO:0007186,GO:0008201,GO:0016020,GO:0016021,GO:0031092,GO:0042802,GO:0043687,GO:0044267,GO:0046914,GO:0070062 platelet degranulation|DNA binding|serine-type endopeptidase inhibitor activity|nucleus|endoplasmic reticulum lumen|plasma membrane|G-protein coupled receptor signaling pathway|heparin binding|membrane|integral component of membrane|platelet alpha granule membrane|identical protein binding|post-translational protein modification|cellular protein metabolic process|transition metal ion binding|extracellular exosome APMAP 3293.74771182514 3050.26515759605 3537.23026605423 1.15964681209615 0.213685477746023 0.11908660357849 1 52.9794 55.5549 64.3876 64.2964 GeneID:57136,Genbank:XM_005260763.3,HGNC:HGNC:13238,MIM:615884 adipocyte plasma membrane associated protein GO:0004064,GO:0005783,GO:0009058,GO:0009986,GO:0016020,GO:0016021,GO:0016844,GO:0070062 arylesterase activity|endoplasmic reticulum|biosynthetic process|cell surface|membrane|integral component of membrane|strictosidine synthase activity|extracellular exosome APOA1 1.97092102469304 1.51824048055703 2.42360156882906 1.59632258516771 0.674752221106181 0.891291031725468 1 0.0440564 0.0761908 0.121655 0.0758861 GeneID:335,Genbank:NM_001318021.1,HGNC:HGNC:600,MIM:107680 apolipoprotein A1 hsa03320,hsa04975,hsa04977,hsa04979,hsa05143 PPAR signaling pathway|Fat digestion and absorption|Vitamin digestion and absorption|Cholesterol metabolism|African trypanosomiasis APOB 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00219831 GeneID:338,Genbank:NM_000384.2,HGNC:HGNC:603,MIM:107730 apolipoprotein B hsa04975,hsa04977,hsa04979 Fat digestion and absorption|Vitamin digestion and absorption|Cholesterol metabolism APOBEC2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:10930,Genbank:NM_006789.3,HGNC:HGNC:605,MIM:604797 apolipoprotein B mRNA editing enzyme catalytic subunit 2 GO:0003723,GO:0004126,GO:0006397,GO:0008270,GO:0016554,GO:0016556,GO:0042802,GO:0080111 RNA binding|cytidine deaminase activity|mRNA processing|zinc ion binding|cytidine to uridine editing|mRNA modification|identical protein binding|DNA demethylation APOBEC3B 3.19066144418956 2.98845468642911 3.39286820195 1.1353252961664 0.183105721240172 1 1 0.28114 0.281986 0.499576 0.246583 GeneID:9582,Genbank:NM_004900.4,HGNC:HGNC:17352,MIM:607110 apolipoprotein B mRNA editing enzyme catalytic subunit 3B GO:0003723,GO:0005634,GO:0008270,GO:0010529,GO:0045087,GO:0047844,GO:0051607 RNA binding|nucleus|zinc ion binding|negative regulation of transposition|innate immune response|deoxycytidine deaminase activity|defense response to virus hsa05170 Human immunodeficiency virus 1 infection APOBEC3C 1908.1885639288 1937.9871113042 1878.3900165534 0.969247940606426 -0.0450623302501407 0.730359347789395 1 51.1546 56.9871 52.2551 51.4475 GeneID:27350,Genbank:XM_024452218.1,HGNC:HGNC:17353,MIM:607750 apolipoprotein B mRNA editing enzyme catalytic subunit 3C GO:0003723,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0010529,GO:0016032,GO:0016814,GO:0045071,GO:0045087,GO:0051607,GO:0080111 RNA binding|nucleus|cytoplasm|zinc ion binding|cytidine deamination|negative regulation of transposition|viral process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|negative regulation of viral genome replication|innate immune response|defense response to virus|DNA demethylation hsa05170 Human immunodeficiency virus 1 infection APOBEC3D 38.8296040722879 39.3683912900049 38.2908168545709 0.972628436160978 -0.0400393234745282 0.951991640936057 1 0.486723 0.527369 0.488094 0.397265 GeneID:140564,Genbank:NM_152426.3,HGNC:HGNC:17354,MIM:609900 apolipoprotein B mRNA editing enzyme catalytic subunit 3D GO:0000932,GO:0005737,GO:0008270,GO:0010529,GO:0016814,GO:0045087,GO:0045869,GO:0051607,GO:0070383 P-body|cytoplasm|zinc ion binding|negative regulation of transposition|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|defense response to virus|DNA cytosine deamination hsa05170 Human immunodeficiency virus 1 infection APOBEC3F 478.877663068278 444.016171476748 513.739154659808 1.15702802659455 0.210423811151757 0.242827113860769 1 2.15252 2.30366 2.90903 2.45677 GeneID:200316,Genbank:XM_024452178.1,HGNC:HGNC:17356,MIM:608993 apolipoprotein B mRNA editing enzyme catalytic subunit 3F hsa05170 Human immunodeficiency virus 1 infection APOBEC3G 43.0813801323512 52.2445179098432 33.9182423548592 0.649221080255557 -0.62321824982834 0.151929999636361 1 0.358072 0.385373 0.156466 0.354893 GeneID:60489,Genbank:XM_017028903.1,HGNC:HGNC:17357,MIM:607113 apolipoprotein B mRNA editing enzyme catalytic subunit 3G hsa05170 Human immunodeficiency virus 1 infection APOBEC3H 4.56198533679619 6.21704074628294 2.90692992730943 0.467574533599033 -1.0967317391215 0.485897618755462 1 0.211535 0.153667 0.079371 0.0741292 GeneID:164668,Genbank:XM_011529991.3,HGNC:HGNC:24100,MIM:610976 apolipoprotein B mRNA editing enzyme catalytic subunit 3H GO:0000932,GO:0004126,GO:0005634,GO:0005737,GO:0008270,GO:0010529,GO:0045087,GO:0045869,GO:0048525,GO:0051607,GO:0070383 P-body|cytidine deaminase activity|nucleus|cytoplasm|zinc ion binding|negative regulation of transposition|innate immune response|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|negative regulation of viral process|defense response to virus|DNA cytosine deamination hsa05170 Human immunodeficiency virus 1 infection APOBR 2.04796353609065 2.64246210852658 1.45346496365472 0.550041932092324 -0.86238648913064 0.823928496362041 1 0.0270426 0.00803058 0.00846323 0.0158412 GeneID:55911,Genbank:NM_018690.3,HGNC:HGNC:24087,MIM:605220 apolipoprotein B receptor GO:0005886,GO:0006641,GO:0006869,GO:0006898,GO:0008203,GO:0016020,GO:0030229,GO:0034361,GO:0034362,GO:0034447,GO:0042627 plasma membrane|triglyceride metabolic process|lipid transport|receptor-mediated endocytosis|cholesterol metabolic process|membrane|very-low-density lipoprotein particle receptor activity|very-low-density lipoprotein particle|low-density lipoprotein particle|very-low-density lipoprotein particle clearance|chylomicron APOC1 15.5196271201252 16.988802934237 14.0504513060134 0.827041867540766 -0.273967729741675 0.74679759635997 1 0.858942 0.572965 0.347245 0.793466 GeneID:341,Genbank:NM_001321066.1,HGNC:HGNC:607,MIM:107710 apolipoprotein C1 hsa04979 Cholesterol metabolism APOC2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0560373 0 GeneID:344,Genbank:NM_000483.4,HGNC:HGNC:609,MIM:608083 apolipoprotein C2 GO:0001523,GO:0005576,GO:0005615,GO:0005769,GO:0008289,GO:0010518,GO:0010898,GO:0010902,GO:0010916,GO:0016004,GO:0016042,GO:0032375,GO:0033344,GO:0033700,GO:0034361,GO:0034362,GO:0034363,GO:0034366,GO:0034370,GO:0034371,GO:0034372,GO:0034375,GO:0034378,GO:0034382,GO:0034384,GO:0042493,GO:0042627,GO:0042632,GO:0042803,GO:0042953,GO:0043274,GO:0043691,GO:0045723,GO:0045833,GO:0048261,GO:0051006,GO:0055102,GO:0060230,GO:0060697,GO:0070062,GO:0070328 retinoid metabolic process|extracellular region|extracellular space|early endosome|lipid binding|positive regulation of phospholipase activity|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|negative regulation of very-low-density lipoprotein particle clearance|phospholipase activator activity|lipid catabolic process|negative regulation of cholesterol transport|cholesterol efflux|phospholipid efflux|very-low-density lipoprotein particle|low-density lipoprotein particle|intermediate-density lipoprotein particle|spherical high-density lipoprotein particle|triglyceride-rich lipoprotein particle remodeling|chylomicron remodeling|very-low-density lipoprotein particle remodeling|high-density lipoprotein particle remodeling|chylomicron assembly|chylomicron remnant clearance|high-density lipoprotein particle clearance|response to drug|chylomicron|cholesterol homeostasis|protein homodimerization activity|lipoprotein transport|phospholipase binding|reverse cholesterol transport|positive regulation of fatty acid biosynthetic process|negative regulation of lipid metabolic process|negative regulation of receptor-mediated endocytosis|positive regulation of lipoprotein lipase activity|lipase inhibitor activity|lipoprotein lipase activator activity|positive regulation of phospholipid catabolic process|extracellular exosome|triglyceride homeostasis hsa04979 Cholesterol metabolism APOD 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0.0356195 0 GeneID:347,Genbank:NM_001647.3,HGNC:HGNC:612,MIM:107740 apolipoprotein D GO:0000302,GO:0001525,GO:0005319,GO:0005576,GO:0005615,GO:0005783,GO:0006006,GO:0006629,GO:0007420,GO:0007568,GO:0010642,GO:0014012,GO:0015485,GO:0022626,GO:0030425,GO:0042246,GO:0042308,GO:0042493,GO:0043025,GO:0048471,GO:0048662,GO:0048678,GO:0051895,GO:0060588,GO:0070062,GO:0071638,GO:1900016,GO:2000098,GO:2000405 response to reactive oxygen species|angiogenesis|lipid transporter activity|extracellular region|extracellular space|endoplasmic reticulum|glucose metabolic process|lipid metabolic process|brain development|aging|negative regulation of platelet-derived growth factor receptor signaling pathway|peripheral nervous system axon regeneration|cholesterol binding|cytosolic ribosome|dendrite|tissue regeneration|negative regulation of protein import into nucleus|response to drug|neuronal cell body|perinuclear region of cytoplasm|negative regulation of smooth muscle cell proliferation|response to axon injury|negative regulation of focal adhesion assembly|negative regulation of lipoprotein lipid oxidation|extracellular exosome|negative regulation of monocyte chemotactic protein-1 production|negative regulation of cytokine production involved in inflammatory response|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of T cell migration APOE 19.4140721129495 15.5666150030498 23.2615292228492 1.49432161187849 0.57949068221567 0.368243440759869 1 0.517554 0.407581 0.596982 0.627008 GeneID:348,Genbank:NM_001302688.1,HGNC:HGNC:613,MIM:107741 apolipoprotein E hsa04979,hsa05010 Cholesterol metabolism|Alzheimer disease APOF 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0 0 0 0 GeneID:319,Genbank:NM_001638.2,HGNC:HGNC:615,MIM:107760 apolipoprotein F GO:0005102,GO:0005319,GO:0005615,GO:0006629,GO:0006869,GO:0008203,GO:0015485,GO:0034362,GO:0034364 receptor binding|lipid transporter activity|extracellular space|lipid metabolic process|lipid transport|cholesterol metabolic process|cholesterol binding|low-density lipoprotein particle|high-density lipoprotein particle APOL1 51.9476572312273 43.7790339076212 60.1162805548334 1.37317512948517 0.457515633006893 0.546480806404453 1 0.345698 0.477546 0.787547 0.334873 GeneID:8542,Genbank:NM_145343.2,HGNC:HGNC:618,MIM:603743 apolipoprotein L1 GO:0005254,GO:0005576,GO:0005615,GO:0005788,GO:0006869,GO:0006898,GO:0008203,GO:0008289,GO:0019835,GO:0031224,GO:0031640,GO:0034361,GO:0034364,GO:0042157,GO:0043687,GO:0044267,GO:0045087,GO:0072562,GO:1902476 chloride channel activity|extracellular region|extracellular space|endoplasmic reticulum lumen|lipid transport|receptor-mediated endocytosis|cholesterol metabolic process|lipid binding|cytolysis|intrinsic component of membrane|killing of cells of other organism|very-low-density lipoprotein particle|high-density lipoprotein particle|lipoprotein metabolic process|post-translational protein modification|cellular protein metabolic process|innate immune response|blood microparticle|chloride transmembrane transport hsa05143 African trypanosomiasis APOL2 1050.99010716125 833.50995582239 1268.4702585001 1.52184176042451 0.605818356660658 0.0364007999281499 0.739899327172153 6.43397 6.86744 12.759 8.4863 GeneID:23780,Genbank:NM_145637.2,HGNC:HGNC:619,MIM:607252 apolipoprotein L2 GO:0005102,GO:0005576,GO:0005789,GO:0006629,GO:0006869,GO:0006953,GO:0007275,GO:0008035,GO:0008203,GO:0008289,GO:0016020,GO:0042157,GO:0060135 receptor binding|extracellular region|endoplasmic reticulum membrane|lipid metabolic process|lipid transport|acute-phase response|multicellular organism development|high-density lipoprotein particle binding|cholesterol metabolic process|lipid binding|membrane|lipoprotein metabolic process|maternal process involved in female pregnancy APOL3 24.0497509402585 25.8002795143615 22.2992223661555 0.864301580676394 -0.210393295195775 0.756539302591879 1 0.153877 0.100104 0.141346 0.0790441 GeneID:80833,Genbank:NM_145642.2,HGNC:HGNC:14868,MIM:607253 apolipoprotein L3 GO:0004871,GO:0005319,GO:0005576,GO:0005737,GO:0006954,GO:0008289,GO:0016020,GO:0042157,GO:0043123 signal transducer activity|lipid transporter activity|extracellular region|cytoplasm|inflammatory response|lipid binding|membrane|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB signaling APOL4 0.97013660517434 0 1.94027321034868 Inf Inf 0.496193947515089 1 0 0 0.0417943 0 GeneID:80832,Genbank:NM_145660.2,HGNC:HGNC:14867,MIM:607254 apolipoprotein L4 GO:0005615,GO:0006629,GO:0006869,GO:0008289,GO:0042157,GO:0043231 extracellular space|lipid metabolic process|lipid transport|lipid binding|lipoprotein metabolic process|intracellular membrane-bounded organelle APOL6 416.426241039724 348.51110002571 484.341382053738 1.38974449312521 0.474819665405856 0.533726035003887 1 1.31556 1.33276 2.77901 0.963585 GeneID:80830,Genbank:XM_011530392.3,HGNC:HGNC:14870,MIM:607256 apolipoprotein L6 GO:0005576,GO:0005737,GO:0006869,GO:0008289,GO:0042157 extracellular region|cytoplasm|lipid transport|lipid binding|lipoprotein metabolic process APOLD1 307.168063860195 309.008438566758 305.327689153631 0.988088514895583 -0.017287807853802 0.933342017886285 1 3.00058 3.0745 3.14866 2.85439 GeneID:81575,Genbank:NM_001130415.1,HGNC:HGNC:25268,MIM:612456 apolipoprotein L domain containing 1 GO:0001525,GO:0001666,GO:0005576,GO:0005654,GO:0005829,GO:0005886,GO:0006869,GO:0008289,GO:0016021,GO:0030154,GO:0042118,GO:0042157,GO:0045601 angiogenesis|response to hypoxia|extracellular region|nucleoplasm|cytosol|plasma membrane|lipid transport|lipid binding|integral component of membrane|cell differentiation|endothelial cell activation|lipoprotein metabolic process|regulation of endothelial cell differentiation APOM 100.540707159045 108.043997147227 93.037417170863 0.861106767866843 -0.215735967692202 0.541538727216125 1 1.36278 0.638024 1.08401 0.922854 GeneID:55937,Genbank:NM_001256169.1,HGNC:HGNC:13916,MIM:606907 apolipoprotein M GO:0001523,GO:0005319,GO:0005543,GO:0005576,GO:0005887,GO:0009749,GO:0016209,GO:0033344,GO:0034361,GO:0034362,GO:0034364,GO:0034365,GO:0034366,GO:0034375,GO:0034380,GO:0034384,GO:0034445,GO:0042157,GO:0042632,GO:0043691,GO:0070062 retinoid metabolic process|lipid transporter activity|phospholipid binding|extracellular region|integral component of plasma membrane|response to glucose|antioxidant activity|cholesterol efflux|very-low-density lipoprotein particle|low-density lipoprotein particle|high-density lipoprotein particle|discoidal high-density lipoprotein particle|spherical high-density lipoprotein particle|high-density lipoprotein particle remodeling|high-density lipoprotein particle assembly|high-density lipoprotein particle clearance|negative regulation of plasma lipoprotein oxidation|lipoprotein metabolic process|cholesterol homeostasis|reverse cholesterol transport|extracellular exosome APOO 376.304769968569 367.354327363298 385.255212573839 1.04872920740862 0.0686422074080426 0.710172164816529 1 4.56605 4.4911 4.60982 5.24567 GeneID:79135,Genbank:NM_024122.4,HGNC:HGNC:28727,MIM:300753 apolipoprotein O GO:0000139,GO:0005576,GO:0005615,GO:0005739,GO:0005789,GO:0005829,GO:0006869,GO:0031305,GO:0034361,GO:0034362,GO:0034364,GO:0042407,GO:0061617 Golgi membrane|extracellular region|extracellular space|mitochondrion|endoplasmic reticulum membrane|cytosol|lipid transport|integral component of mitochondrial inner membrane|very-low-density lipoprotein particle|low-density lipoprotein particle|high-density lipoprotein particle|cristae formation|MICOS complex APOOL 275.127783266318 287.559949739365 262.695616793271 0.913533393754482 -0.130470628077911 0.70100840438051 1 1.90852 1.48879 1.71569 1.33403 GeneID:139322,Genbank:XM_017029272.1,HGNC:HGNC:24009,MIM:300955 apolipoprotein O like GO:0002576,GO:0005576,GO:0005739,GO:0031093,GO:0042407,GO:0061617 platelet degranulation|extracellular region|mitochondrion|platelet alpha granule lumen|cristae formation|MICOS complex APOPT1 1056.95233316193 1029.38056112275 1084.5241052011 1.0535696380532 0.0752856754781067 0.618089227974068 1 8.74886 9.46993 9.42616 10.6531 GeneID:84334,Genbank:NM_032374.4,HGNC:HGNC:20492,MIM:616003 apoptogenic 1, mitochondrial GO:0005739,GO:0034393,GO:0043280,GO:0090200,GO:0097193 mitochondrion|positive regulation of smooth muscle cell apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of release of cytochrome c from mitochondria|intrinsic apoptotic signaling pathway APP 19215.8143050841 19295.193899001 19136.4347111673 0.991772086423969 -0.011919473835659 0.927622988328344 1 136.586 134.605 143.275 128.996 GeneID:351,Genbank:NM_001136131.2,HGNC:HGNC:620,MIM:104760 amyloid beta precursor protein GO:0003677,GO:0004867,GO:0005737,GO:0005794,GO:0005905,GO:0006378,GO:0006417,GO:0006468,GO:0006878,GO:0006897,GO:0006915,GO:0007155,GO:0007176,GO:0007219,GO:0007409,GO:0007617,GO:0007626,GO:0008088,GO:0008201,GO:0008344,GO:0008542,GO:0016021,GO:0016199,GO:0016322,GO:0016358,GO:0030198,GO:0030424,GO:0031175,GO:0035235,GO:0040014,GO:0045931,GO:0046914,GO:0048669,GO:0050803 DNA binding|serine-type endopeptidase inhibitor activity|cytoplasm|Golgi apparatus|clathrin-coated pit|mRNA polyadenylation|regulation of translation|protein phosphorylation|cellular copper ion homeostasis|endocytosis|apoptotic process|cell adhesion|regulation of epidermal growth factor-activated receptor activity|Notch signaling pathway|axonogenesis|mating behavior|locomotory behavior|axo-dendritic transport|heparin binding|adult locomotory behavior|visual learning|integral component of membrane|axon midline choice point recognition|neuron remodeling|dendrite development|extracellular matrix organization|axon|neuron projection development|ionotropic glutamate receptor signaling pathway|regulation of multicellular organism growth|positive regulation of mitotic cell cycle|transition metal ion binding|collateral sprouting in absence of injury|regulation of synapse structure or activity hsa04726,hsa05010 Serotonergic synapse|Alzheimer disease APPBP2 630.857141756872 643.268233315273 618.446050198472 0.961412390926143 -0.0567726974730261 0.790855841169215 1 4.70335 4.11952 4.86566 3.69717 GeneID:10513,Genbank:NM_001282476.1,HGNC:HGNC:622,MIM:605324 amyloid beta precursor protein binding protein 2 GO:0003777,GO:0005634,GO:0005737,GO:0005874,GO:0005875,GO:0006886,GO:0030659,GO:0046907 microtubule motor activity|nucleus|cytoplasm|microtubule|microtubule associated complex|intracellular protein transport|cytoplasmic vesicle membrane|intracellular transport APPL1 767.621130126943 793.621050164249 741.621210089638 0.934477745942035 -0.097767787472685 0.766168459441638 1 5.6845 5.02164 6.41111 3.90947 GeneID:26060,Genbank:NM_012096.2,HGNC:HGNC:24035,MIM:604299 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 GO:0005634,GO:0005769,GO:0005829,GO:0007049,GO:0007165,GO:0008283,GO:0008286,GO:0010008,GO:0012506,GO:0031901,GO:0042802,GO:0043422,GO:0046324,GO:0070062,GO:0097192,GO:1903076 nucleus|early endosome|cytosol|cell cycle|signal transduction|cell proliferation|insulin receptor signaling pathway|endosome membrane|vesicle membrane|early endosome membrane|identical protein binding|protein kinase B binding|regulation of glucose import|extracellular exosome|extrinsic apoptotic signaling pathway in absence of ligand|regulation of protein localization to plasma membrane hsa04211,hsa05200,hsa05210 Longevity regulating pathway|Pathways in cancer|Colorectal cancer APPL2 405.788288641759 413.689579485184 397.886997798334 0.961800870820783 -0.0561898624476515 0.761380813043224 1 1.56774 1.59886 1.6563 1.46845 GeneID:55198,Genbank:NM_018171.3,HGNC:HGNC:18242,MIM:606231 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 GO:0005634,GO:0007049,GO:0007165,GO:0008283,GO:0010008,GO:0031901,GO:0070062 nucleus|cell cycle|signal transduction|cell proliferation|endosome membrane|early endosome membrane|extracellular exosome APRT 1521.90434473819 1541.13346427495 1502.67522520142 0.97504548440156 -0.0364585749071599 0.85362535518835 1 78.0556 89.3719 78.7853 94.0601 GeneID:353,Genbank:NM_001030018.1,HGNC:HGNC:626,MIM:102600 adenine phosphoribosyltransferase hsa00230 Purine metabolism APTX 973.321939686582 989.02323537458 957.620643998584 0.968248884098155 -0.0465501613313759 0.753107537481759 1 2.98335 3.25454 3.45376 3.1379 GeneID:54840,Genbank:XM_017014831.1,HGNC:HGNC:15984,MIM:606350 aprataxin GO:0000012,GO:0000785,GO:0003682,GO:0003684,GO:0003690,GO:0003725,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006266,GO:0006302,GO:0006974,GO:0008967,GO:0031647,GO:0033699,GO:0042542,GO:0046403,GO:0046872,GO:0047485,GO:0051219,GO:0120108 single strand break repair|chromatin|chromatin binding|damaged DNA binding|double-stranded DNA binding|double-stranded RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA ligation|double-strand break repair|cellular response to DNA damage stimulus|phosphoglycolate phosphatase activity|regulation of protein stability|DNA 5'-adenosine monophosphate hydrolase activity|response to hydrogen peroxide|polynucleotide 3'-phosphatase activity|metal ion binding|protein N-terminus binding|phosphoprotein binding|DNA-3'-diphospho-5'-guanosine diphosphatase AQP1 40.2452834308053 53.3589308827048 27.1316359789058 0.508474130385921 -0.97575371886425 0.0699712034829456 0.92021045003939 0.910457 0.568657 0.239798 0.51785 GeneID:358,Genbank:NM_198098.3,HGNC:HGNC:633,MIM:107776 aquaporin 1 (Colton blood group) hsa04924,hsa04964,hsa04976 Renin secretion|Proximal tubule bicarbonate reclamation|Bile secretion AQP10 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0518365 0 GeneID:89872,Genbank:XM_011510104.2,HGNC:HGNC:16029,MIM:606578 aquaporin 10 GO:0005886,GO:0006833,GO:0009636,GO:0015250,GO:0015254,GO:0015265,GO:0016021 plasma membrane|water transport|response to toxic substance|water channel activity|glycerol channel activity|urea channel activity|integral component of membrane AQP11 54.7516736045559 44.5572629576882 64.9460842514236 1.45758693286652 0.54358193068154 0.165823876719288 1 1.06093 1.17039 1.82729 1.38754 GeneID:282679,Genbank:XM_005273917.5,HGNC:HGNC:19940,MIM:609914 aquaporin 11 GO:0005783,GO:0005829,GO:0005886,GO:0009986,GO:0015267,GO:0016021,GO:0030425,GO:0048388,GO:0051260,GO:0072014 endoplasmic reticulum|cytosol|plasma membrane|cell surface|channel activity|integral component of membrane|dendrite|endosomal lumen acidification|protein homooligomerization|proximal tubule development AQP2 0.729234031512454 0.490071401957362 0.968396661067546 1.97603177251261 0.982606144127986 1 1 0 0.00960752 0 0.0188525 GeneID:359,Genbank:NM_000486.5,HGNC:HGNC:634,MIM:107777 aquaporin 2 GO:0003091,GO:0003097,GO:0005372,GO:0005794,GO:0005886,GO:0005887,GO:0006833,GO:0007588,GO:0015168,GO:0015250,GO:0015793,GO:0016020,GO:0016323,GO:0016324,GO:0030658,GO:0034220,GO:0042631,GO:0055037,GO:0070062,GO:0071280,GO:0071288,GO:0072205 renal water homeostasis|renal water transport|water transmembrane transporter activity|Golgi apparatus|plasma membrane|integral component of plasma membrane|water transport|excretion|glycerol transmembrane transporter activity|water channel activity|glycerol transport|membrane|basolateral plasma membrane|apical plasma membrane|transport vesicle membrane|ion transmembrane transport|cellular response to water deprivation|recycling endosome|extracellular exosome|cellular response to copper ion|cellular response to mercury ion|metanephric collecting duct development hsa04962 Vasopressin-regulated water reabsorption AQP3 25.3274154667053 29.8169032793903 20.8379276540202 0.698862905338111 -0.516918622387094 0.372310522446464 1 0.751491 0.687056 0.460172 0.50502 GeneID:360,Genbank:NM_001318144.1,HGNC:HGNC:636,MIM:600170 aquaporin 3 (Gill blood group) hsa04962 Vasopressin-regulated water reabsorption AQP4 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00749118 0 0 0 GeneID:361,Genbank:NM_001317387.2,HGNC:HGNC:637,MIM:600308 aquaporin 4 hsa04962,hsa04976 Vasopressin-regulated water reabsorption|Bile secretion AQP5 8.28323980857276 8.81147658012458 7.75500303702094 0.880102553357896 -0.184256452273276 0.930494410236801 1 0.271901 0.143395 0.248302 0.202757 GeneID:362,Genbank:NM_001651.3,HGNC:HGNC:638,MIM:600442 aquaporin 5 GO:0005783,GO:0005886,GO:0005887,GO:0005902,GO:0006833,GO:0007588,GO:0009925,GO:0015250,GO:0015670,GO:0016324,GO:0030157,GO:0034220,GO:0042476,GO:0042802,GO:0046541,GO:0048593,GO:0070062 endoplasmic reticulum|plasma membrane|integral component of plasma membrane|microvillus|water transport|excretion|basal plasma membrane|water channel activity|carbon dioxide transport|apical plasma membrane|pancreatic juice secretion|ion transmembrane transport|odontogenesis|identical protein binding|saliva secretion|camera-type eye morphogenesis|extracellular exosome hsa04970 Salivary secretion AQP6 3.26313584224367 3.13253351048394 3.3937381740034 1.08338447542389 0.115545322680473 1 1 0.0667667 0.014843 0.077951 0.0146363 GeneID:363,Genbank:NM_001652.3,HGNC:HGNC:639,MIM:601383 aquaporin 6 GO:0005253,GO:0005887,GO:0006810,GO:0006833,GO:0007588,GO:0015112,GO:0015250,GO:0016324,GO:0030658,GO:0034220,GO:0042476 anion channel activity|integral component of plasma membrane|transport|water transport|excretion|nitrate transmembrane transporter activity|water channel activity|apical plasma membrane|transport vesicle membrane|ion transmembrane transport|odontogenesis AQP7 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0 GeneID:364,Genbank:XM_017014701.1,HGNC:HGNC:640,MIM:602974 aquaporin 7 GO:0005737,GO:0005886,GO:0005887,GO:0005911,GO:0006091,GO:0006833,GO:0007588,GO:0015250,GO:0015254,GO:0015793 cytoplasm|plasma membrane|integral component of plasma membrane|cell-cell junction|generation of precursor metabolites and energy|water transport|excretion|water channel activity|glycerol channel activity|glycerol transport hsa03320,hsa04923 PPAR signaling pathway|Regulation of lipolysis in adipocytes AQP8 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0434092 0 GeneID:343,Genbank:XM_011545823.2,HGNC:HGNC:642,MIM:603750 aquaporin 8 GO:0005886,GO:0005887,GO:0006810,GO:0006833,GO:0015250,GO:0034220,GO:0045177,GO:0071320 plasma membrane|integral component of plasma membrane|transport|water transport|water channel activity|ion transmembrane transport|apical part of cell|cellular response to cAMP hsa04976 Bile secretion AQR 846.72389077397 878.709143659489 814.738637888451 0.927199453615989 -0.109048378700156 0.586473180159496 1 5.63522 4.91717 5.54436 4.28783 GeneID:9716,Genbank:NM_014691.2,HGNC:HGNC:29513,MIM:610548 aquarius intron-binding spliceosomal factor GO:0000398,GO:0003723,GO:0005654,GO:0006283,GO:0016020,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|transcription-coupled nucleotide-excision repair|membrane|catalytic step 2 spliceosome hsa03040 Spliceosome AR 889.877571999875 815.185208851227 964.569935148523 1.18325249854301 0.242757968458536 0.377684634650094 1 2.52883 2.63359 3.71435 2.44985 GeneID:367,Genbank:NM_001011645.3,HGNC:HGNC:644,MIM:313700 androgen receptor hsa04114,hsa05200,hsa05215 Oocyte meiosis|Pathways in cancer|Prostate cancer ARAF 1426.07644262573 1461.78992343254 1390.36296181892 0.951137327964407 -0.0722744382707187 0.605469746762327 1 8.53714 9.02829 8.37391 8.83119 GeneID:369,Genbank:NM_001256196.1,HGNC:HGNC:646,MIM:311010 A-Raf proto-oncogene, serine/threonine kinase GO:0000165,GO:0004672,GO:0004674,GO:0004709,GO:0005524,GO:0005739,GO:0005829,GO:0006464,GO:0007275,GO:0009968,GO:0030154,GO:0031434,GO:0032006,GO:0032434,GO:0033138,GO:0043066,GO:0046872,GO:0070374 MAPK cascade|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|ATP binding|mitochondrion|cytosol|cellular protein modification process|multicellular organism development|negative regulation of signal transduction|cell differentiation|mitogen-activated protein kinase kinase binding|regulation of TOR signaling|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of peptidyl-serine phosphorylation|negative regulation of apoptotic process|metal ion binding|positive regulation of ERK1 and ERK2 cascade hsa01521,hsa01522,hsa04010,hsa04012,hsa04068,hsa04270,hsa04650,hsa04720,hsa04726,hsa04730,hsa04810,hsa04910,hsa04914,hsa04928,hsa05034,hsa05160,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|FoxO signaling pathway|Vascular smooth muscle contraction|Natural killer cell mediated cytotoxicity|Long-term potentiation|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Parathyroid hormone synthesis, secretion and action|Alcoholism|Hepatitis C|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer ARAP1 1192.16495869551 1062.25457967433 1322.0753377167 1.24459368122661 0.3156748268271 0.0365884565506232 0.739899327172153 6.06969 6.47064 8.2813 7.91223 GeneID:116985,Genbank:NM_001040118.2,HGNC:HGNC:16925,MIM:606646 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 GO:0001921,GO:0005096,GO:0005547,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0007165,GO:0008360,GO:0030037,GO:0031410,GO:0031702,GO:0032580,GO:0043231,GO:0043547,GO:0045742,GO:0046872,GO:0051056,GO:0051270,GO:0051491,GO:0051497 positive regulation of receptor recycling|GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|signal transduction|regulation of cell shape|actin filament reorganization involved in cell cycle|cytoplasmic vesicle|type 1 angiotensin receptor binding|Golgi cisterna membrane|intracellular membrane-bounded organelle|positive regulation of GTPase activity|positive regulation of epidermal growth factor receptor signaling pathway|metal ion binding|regulation of small GTPase mediated signal transduction|regulation of cellular component movement|positive regulation of filopodium assembly|negative regulation of stress fiber assembly hsa04144 Endocytosis ARAP2 60.0041241975365 57.4814158522114 62.5268325428615 1.08777474625229 0.121379837737426 0.762628379294846 1 0.228836 0.257049 0.323299 0.223912 GeneID:116984,Genbank:NM_015230.3,HGNC:HGNC:16924,MIM:606645 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 GO:0005096,GO:0005547,GO:0005829,GO:0007165,GO:0046872,GO:0051056 GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|signal transduction|metal ion binding|regulation of small GTPase mediated signal transduction hsa04144 Endocytosis ARAP3 1093.26083789544 1159.1808220557 1027.34085373518 0.886264536289764 -0.174190709617105 0.240864335312737 1 6.80534 7.02185 5.95581 6.57509 GeneID:64411,Genbank:NM_022481.5,HGNC:HGNC:24097,MIM:606647 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 GO:0001726,GO:0005096,GO:0005547,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0007010,GO:0007165,GO:0008360,GO:0016192,GO:0030027,GO:0030336,GO:0035021,GO:0035024,GO:0043325,GO:0046872,GO:0051056 ruffle|GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytosol|cytoskeleton|plasma membrane|cytoskeleton organization|signal transduction|regulation of cell shape|vesicle-mediated transport|lamellipodium|negative regulation of cell migration|negative regulation of Rac protein signal transduction|negative regulation of Rho protein signal transduction|phosphatidylinositol-3,4-bisphosphate binding|metal ion binding|regulation of small GTPase mediated signal transduction hsa04015,hsa04024,hsa04144 Rap1 signaling pathway|cAMP signaling pathway|Endocytosis ARC 5.31816904136291 7.24520982488261 3.3911282578432 0.468051076477713 -1.09526212114634 0.437971446655031 1 0.147663 0.0925313 0.0335314 0.078587 GeneID:23237,Genbank:NM_015193.4,HGNC:HGNC:648,MIM:612461 activity regulated cytoskeleton associated protein GO:0001669,GO:0005737,GO:0005768,GO:0005886,GO:0006897,GO:0007010,GO:0007492,GO:0007612,GO:0007616,GO:0009952,GO:0014069,GO:0015629,GO:0016477,GO:0022604,GO:0030054,GO:0043025,GO:0043197,GO:0045211,GO:0048168,GO:0060291,GO:0060997,GO:0061001,GO:1900271,GO:2000969 acrosomal vesicle|cytoplasm|endosome|plasma membrane|endocytosis|cytoskeleton organization|endoderm development|learning|long-term memory|anterior/posterior pattern specification|postsynaptic density|actin cytoskeleton|cell migration|regulation of cell morphogenesis|cell junction|neuronal cell body|dendritic spine|postsynaptic membrane|regulation of neuronal synaptic plasticity|long-term synaptic potentiation|dendritic spine morphogenesis|regulation of dendritic spine morphogenesis|regulation of long-term synaptic potentiation|positive regulation of AMPA receptor activity hsa05031 Amphetamine addiction ARCN1 4083.29180881208 4133.69358375475 4032.89003386941 0.975614169787162 -0.0356173829471828 0.79750551876087 1 41.0771 41.3931 45.1139 36.3419 GeneID:372,Genbank:NM_001655.4,HGNC:HGNC:649,MIM:600820 archain 1 GO:0000139,GO:0003723,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0008344,GO:0016020,GO:0021691,GO:0030126,GO:0030133,GO:0043473 Golgi membrane|RNA binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|adult locomotory behavior|membrane|cerebellar Purkinje cell layer maturation|COPI vesicle coat|transport vesicle|pigmentation AREL1 1977.01659078332 2050.85335323014 1903.17982833649 0.927994108081371 -0.107812449306899 0.442706556797688 1 13.4804 13.9164 13.7821 12.3646 GeneID:9870,Genbank:NM_001039479.1,HGNC:HGNC:20363,MIM:615380 apoptosis resistant E3 ubiquitin protein ligase 1 GO:0004842,GO:0005829,GO:0006915,GO:0042787,GO:0043066,GO:0061630 ubiquitin-protein transferase activity|cytosol|apoptotic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of apoptotic process|ubiquitin protein ligase activity ARF1 11412.8545738529 11173.6893981448 11652.0197495611 1.04280863145307 0.0604744293967339 0.657880051274382 1 172.23 179.338 186.394 191.759 GeneID:375,Genbank:NM_001024226.1,HGNC:HGNC:652,MIM:103180 ADP ribosylation factor 1 GO:0000287,GO:0002090,GO:0003723,GO:0005525,GO:0005770,GO:0005794,GO:0005829,GO:0005925,GO:0006878,GO:0007015,GO:0007264,GO:0012505,GO:0014069,GO:0015031,GO:0016192,GO:0019003,GO:0019904,GO:0030017,GO:0031252,GO:0034315,GO:0034379,GO:0043005,GO:0043234,GO:0045211,GO:0045807,GO:0045956,GO:0046982,GO:0048471,GO:0050714,GO:0055108,GO:0060292,GO:0060999,GO:0070062,GO:0070142,GO:0097061,GO:0097212,GO:0098586,GO:1902307,GO:1902824,GO:1902953,GO:1903725,GO:1990386,GO:1990583 magnesium ion binding|regulation of receptor internalization|RNA binding|GTP binding|late endosome|Golgi apparatus|cytosol|focal adhesion|cellular copper ion homeostasis|actin filament organization|small GTPase mediated signal transduction|endomembrane system|postsynaptic density|protein transport|vesicle-mediated transport|GDP binding|protein domain specific binding|sarcomere|cell leading edge|regulation of Arp2/3 complex-mediated actin nucleation|very-low-density lipoprotein particle assembly|neuron projection|protein complex|postsynaptic membrane|positive regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|protein heterodimerization activity|perinuclear region of cytoplasm|positive regulation of protein secretion|Golgi to transport vesicle transport|long term synaptic depression|positive regulation of dendritic spine development|extracellular exosome|synaptic vesicle budding|dendritic spine organization|lysosomal membrane organization|cellular response to virus|positive regulation of sodium ion transmembrane transport|positive regulation of late endosome to lysosome transport|positive regulation of ER to Golgi vesicle-mediated transport|regulation of phospholipid metabolic process|mitotic cleavage furrow ingression|phospholipase D activator activity hsa04072,hsa04144,hsa05110,hsa05134 Phospholipase D signaling pathway|Endocytosis|Vibrio cholerae infection|Legionellosis ARF3 5643.95556737712 5748.29954070373 5539.61159405052 0.963695707717476 -0.0533504155153034 0.676373058425943 1 46.7407 49.1431 46.2963 47.5982 GeneID:377,Genbank:XM_006719391.4,HGNC:HGNC:654,MIM:103190 ADP ribosylation factor 3 GO:0005525,GO:0005794,GO:0006890,GO:0007264,GO:0015031,GO:0048471,GO:0070062 GTP binding|Golgi apparatus|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction|protein transport|perinuclear region of cytoplasm|extracellular exosome hsa04144 Endocytosis ARF4 8572.68361552512 8702.54281913058 8442.82441191966 0.970156032253011 -0.0437112972221825 0.745823150044934 1 267.508 265.968 273.034 250.609 GeneID:378,Genbank:NM_001660.3,HGNC:HGNC:655,MIM:601177 ADP ribosylation factor 4 GO:0003924,GO:0005086,GO:0005154,GO:0005525,GO:0005794,GO:0005829,GO:0006471,GO:0006888,GO:0006890,GO:0007173,GO:0007264,GO:0007420,GO:0007612,GO:0015031,GO:0016020,GO:0016477,GO:0031012,GO:0031584,GO:0032587,GO:0043066,GO:0043197,GO:0045176,GO:0045197,GO:0045944,GO:0048678,GO:0060996,GO:0061512,GO:0070062,GO:2000377 GTPase activity|ARF guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|GTP binding|Golgi apparatus|cytosol|protein ADP-ribosylation|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|epidermal growth factor receptor signaling pathway|small GTPase mediated signal transduction|brain development|learning|protein transport|membrane|cell migration|extracellular matrix|activation of phospholipase D activity|ruffle membrane|negative regulation of apoptotic process|dendritic spine|apical protein localization|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of transcription from RNA polymerase II promoter|response to axon injury|dendritic spine development|protein localization to cilium|extracellular exosome|regulation of reactive oxygen species metabolic process ARF5 3572.21654046882 3417.8812676447 3726.55181329294 1.09031049398066 0.124739038064302 0.430900710573219 1 148.108 160.628 162.668 179.795 GeneID:381,Genbank:NM_001662.3,HGNC:HGNC:658,MIM:103188 ADP ribosylation factor 5 GO:0005525,GO:0005737,GO:0005794,GO:0005886,GO:0006890,GO:0007264,GO:0015031,GO:0048471,GO:0070062 GTP binding|cytoplasm|Golgi apparatus|plasma membrane|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction|protein transport|perinuclear region of cytoplasm|extracellular exosome hsa04144 Endocytosis ARF6 1601.46469063576 1639.43183431111 1563.49754696041 0.953682558944201 -0.0684189616211049 0.630447007633017 1 19.3766 20.7466 20.818 17.5572 GeneID:382,Genbank:NM_001663.3,HGNC:HGNC:659,MIM:600464 ADP ribosylation factor 6 GO:0001726,GO:0001889,GO:0003924,GO:0005525,GO:0005768,GO:0005769,GO:0005794,GO:0005829,GO:0005886,GO:0005925,GO:0005938,GO:0006928,GO:0007049,GO:0007155,GO:0007264,GO:0007399,GO:0015031,GO:0016020,GO:0016192,GO:0030139,GO:0030154,GO:0030838,GO:0030866,GO:0031527,GO:0031529,GO:0031996,GO:0032154,GO:0033028,GO:0034394,GO:0035020,GO:0036010,GO:0043209,GO:0047485,GO:0048261,GO:0051301,GO:0051489,GO:0055038,GO:0060998,GO:0070062,GO:0090162,GO:0090543,GO:0097284,GO:1903078,GO:2000171 ruffle|liver development|GTPase activity|GTP binding|endosome|early endosome|Golgi apparatus|cytosol|plasma membrane|focal adhesion|cell cortex|movement of cell or subcellular component|cell cycle|cell adhesion|small GTPase mediated signal transduction|nervous system development|protein transport|membrane|vesicle-mediated transport|endocytic vesicle|cell differentiation|positive regulation of actin filament polymerization|cortical actin cytoskeleton organization|filopodium membrane|ruffle organization|thioesterase binding|cleavage furrow|myeloid cell apoptotic process|protein localization to cell surface|regulation of Rac protein signal transduction|protein localization to endosome|myelin sheath|protein N-terminus binding|negative regulation of receptor-mediated endocytosis|cell division|regulation of filopodium assembly|recycling endosome membrane|regulation of dendritic spine development|extracellular exosome|establishment of epithelial cell polarity|Flemming body|hepatocyte apoptotic process|positive regulation of protein localization to plasma membrane|negative regulation of dendrite development hsa04014,hsa04072,hsa04144,hsa04666 Ras signaling pathway|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis ARFGAP1 1618.7129856359 1628.91102915255 1608.51494211925 0.987478697934834 -0.0181784684472272 0.882017945799858 1 15.6863 16.3937 17.5809 15.759 GeneID:55738,Genbank:NM_175609.2,HGNC:HGNC:15852,MIM:608377 ADP ribosylation factor GTPase activating protein 1 GO:0005096,GO:0005794,GO:0005829,GO:0006888,GO:0006890,GO:0014069,GO:0015031,GO:0030100,GO:0036498,GO:0046872 GTPase activator activity|Golgi apparatus|cytosol|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|postsynaptic density|protein transport|regulation of endocytosis|IRE1-mediated unfolded protein response|metal ion binding hsa04144 Endocytosis ARFGAP2 1947.78326256989 1976.02835021154 1919.53817492823 0.971412264769756 -0.0418443933612202 0.75837572998608 1 22.3717 22.9199 22.2083 22.6122 GeneID:84364,Genbank:NM_001242832.1,HGNC:HGNC:13504,MIM:606908 ADP ribosylation factor GTPase activating protein 2 GO:0000139,GO:0005096,GO:0005794,GO:0005829,GO:0005886,GO:0006888,GO:0006890,GO:0015031,GO:0046872 Golgi membrane|GTPase activator activity|Golgi apparatus|cytosol|plasma membrane|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|protein transport|metal ion binding hsa04144 Endocytosis ARFGAP3 1007.19539669245 988.907565514994 1025.4832278699 1.03698592631948 0.0523963144338015 0.738293226060431 1 12.6286 13.467 14.1855 13.1702 GeneID:26286,Genbank:NM_001142293.1,HGNC:HGNC:661,MIM:612439 ADP ribosylation factor GTPase activating protein 3 GO:0000139,GO:0005096,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0008565,GO:0009306,GO:0016020,GO:0016192,GO:0046872 Golgi membrane|GTPase activator activity|Golgi apparatus|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|protein transporter activity|protein secretion|membrane|vesicle-mediated transport|metal ion binding hsa04144 Endocytosis ARFGEF1 437.613842082131 429.264986142487 445.962698021774 1.03889837843365 0.0550545415376196 0.879952794250609 1 1.69301 1.44265 2.1091 1.18085 GeneID:10565,Genbank:XM_005251136.4,HGNC:HGNC:15772,MIM:604141 ADP ribosylation factor guanine nucleotide exchange factor 1 GO:0000139,GO:0005085,GO:0005086,GO:0005654,GO:0005730,GO:0005794,GO:0005802,GO:0005829,GO:0006887,GO:0007030,GO:0010256,GO:0015031,GO:0016363,GO:0017022,GO:0030532,GO:0030837,GO:0031175,GO:0032012,GO:0034237,GO:0034260,GO:0048471,GO:0051897,GO:0090284,GO:0090303,GO:2000114 Golgi membrane|guanyl-nucleotide exchange factor activity|ARF guanyl-nucleotide exchange factor activity|nucleoplasm|nucleolus|Golgi apparatus|trans-Golgi network|cytosol|exocytosis|Golgi organization|endomembrane system organization|protein transport|nuclear matrix|myosin binding|small nuclear ribonucleoprotein complex|negative regulation of actin filament polymerization|neuron projection development|regulation of ARF protein signal transduction|protein kinase A regulatory subunit binding|negative regulation of GTPase activity|perinuclear region of cytoplasm|positive regulation of protein kinase B signaling|positive regulation of protein glycosylation in Golgi|positive regulation of wound healing|regulation of establishment of cell polarity hsa04144 Endocytosis ARFGEF2 854.875551363715 875.115964712371 834.635138015059 0.953742328640277 -0.0683285471101962 0.745462298209368 1 3.81345 3.51385 4.00947 2.9309 GeneID:10564,Genbank:XM_005260252.3,HGNC:HGNC:15853,MIM:605371 ADP ribosylation factor guanine nucleotide exchange factor 2 GO:0000139,GO:0001881,GO:0005085,GO:0005086,GO:0005802,GO:0005815,GO:0005829,GO:0005879,GO:0006887,GO:0006893,GO:0007032,GO:0010256,GO:0015031,GO:0016020,GO:0017022,GO:0030054,GO:0031410,GO:0032012,GO:0032279,GO:0032280,GO:0032760,GO:0034237,GO:0035556,GO:0043197,GO:0048471,GO:0050811,GO:0055037 Golgi membrane|receptor recycling|guanyl-nucleotide exchange factor activity|ARF guanyl-nucleotide exchange factor activity|trans-Golgi network|microtubule organizing center|cytosol|axonemal microtubule|exocytosis|Golgi to plasma membrane transport|endosome organization|endomembrane system organization|protein transport|membrane|myosin binding|cell junction|cytoplasmic vesicle|regulation of ARF protein signal transduction|asymmetric synapse|symmetric synapse|positive regulation of tumor necrosis factor production|protein kinase A regulatory subunit binding|intracellular signal transduction|dendritic spine|perinuclear region of cytoplasm|GABA receptor binding|recycling endosome hsa04144 Endocytosis ARFGEF3 827.329438252081 750.59285334308 904.066023161083 1.2044692660401 0.268397581374447 0.544900728511504 1 1.92407 1.97648 3.15208 1.67034 GeneID:57221,Genbank:NM_020340.4,HGNC:HGNC:21213,MIM:617411 ARFGEF family member 3 GO:0005086,GO:0010923,GO:0016021,GO:0030658,GO:0032012 ARF guanyl-nucleotide exchange factor activity|negative regulation of phosphatase activity|integral component of membrane|transport vesicle membrane|regulation of ARF protein signal transduction ARFIP1 421.500795087143 483.892217477216 359.109372697069 0.742126778912243 -0.430262428682478 0.0371512466291061 0.744556882325193 3.20606 2.62589 2.27558 2.24897 GeneID:27236,Genbank:NM_001287432.1,HGNC:HGNC:21496,MIM:605928 ADP ribosylation factor interacting protein 1 GO:0000139,GO:0005829,GO:0006886,GO:0019904,GO:0032588,GO:0034315,GO:0045296,GO:0050708,GO:0070273 Golgi membrane|cytosol|intracellular protein transport|protein domain specific binding|trans-Golgi network membrane|regulation of Arp2/3 complex-mediated actin nucleation|cadherin binding|regulation of protein secretion|phosphatidylinositol-4-phosphate binding ARFIP2 1235.7718110631 1225.11893025588 1246.42469187033 1.01739077006181 0.0248739110033142 0.894475977516353 1 8.03637 9.0717 8.93572 8.96527 GeneID:23647,Genbank:NM_001242856.1,HGNC:HGNC:17160,MIM:601638 ADP ribosylation factor interacting protein 2 GO:0001726,GO:0005525,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0006928,GO:0007264,GO:0019904,GO:0030032,GO:0030036,GO:0030742,GO:0031529,GO:0032588,GO:0034315,GO:0042802,GO:0045296,GO:0048365,GO:0070273 ruffle|GTP binding|cytoplasm|cytosol|plasma membrane|cell cortex|movement of cell or subcellular component|small GTPase mediated signal transduction|protein domain specific binding|lamellipodium assembly|actin cytoskeleton organization|GTP-dependent protein binding|ruffle organization|trans-Golgi network membrane|regulation of Arp2/3 complex-mediated actin nucleation|identical protein binding|cadherin binding|Rac GTPase binding|phosphatidylinositol-4-phosphate binding ARFRP1 805.520937433855 804.163506634741 806.878368232969 1.00337600696355 0.00486234545865544 0.981135743140626 1 10.608 9.27478 9.98056 10.4508 GeneID:10139,Genbank:NM_001267546.2,HGNC:HGNC:662,MIM:604699 ADP ribosylation factor related protein 1 GO:0003924,GO:0005525,GO:0005794,GO:0005802,GO:0005829,GO:0007165,GO:0007264,GO:0007369,GO:0016020,GO:0032588,GO:0034067,GO:0042147,GO:0043001 GTPase activity|GTP binding|Golgi apparatus|trans-Golgi network|cytosol|signal transduction|small GTPase mediated signal transduction|gastrulation|membrane|trans-Golgi network membrane|protein localization to Golgi apparatus|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport ARG2 524.321161260462 507.810680624612 540.831641896311 1.06502612593946 0.0908888213440618 0.614110866021719 1 8.71428 10.1209 10.3526 10.0875 GeneID:384,Genbank:NM_001172.3,HGNC:HGNC:664,MIM:107830 arginase 2 hsa00220,hsa00330,hsa05146 Arginine biosynthesis|Arginine and proline metabolism|Amoebiasis ARGFX 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00730158 0 GeneID:503582,Genbank:NM_001012659.1,HGNC:HGNC:30146,MIM:611164 arginine-fifty homeobox GO:0005634,GO:0006351,GO:0006355,GO:0043565 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|sequence-specific DNA binding ARGLU1 1057.44614879045 1101.46704948346 1013.42524809744 0.920068601754991 -0.120186660106952 0.439592172911989 1 20.4476 19.6005 20.8783 17.3413 GeneID:55082,Genbank:NM_018011.3,HGNC:HGNC:25482,MIM:614046 arginine and glutamate rich 1 ARHGAP1 2020.68968219519 2098.07371260743 1943.30565178295 0.926233258681777 -0.110552533404169 0.420197496945816 1 19.044 19.8754 18.4637 18.4535 GeneID:392,Genbank:NM_004308.3,HGNC:HGNC:673,MIM:602732 Rho GTPase activating protein 1 GO:0005070,GO:0005096,GO:0005737,GO:0005829,GO:0007264,GO:0007266,GO:0010008,GO:0017124,GO:0017137,GO:0032439,GO:0033572,GO:0045296,GO:0048471,GO:0051056,GO:0070062,GO:0098706,GO:2001136 SH3/SH2 adaptor activity|GTPase activator activity|cytoplasm|cytosol|small GTPase mediated signal transduction|Rho protein signal transduction|endosome membrane|SH3 domain binding|Rab GTPase binding|endosome localization|transferrin transport|cadherin binding|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction|extracellular exosome|ferric iron import across plasma membrane|negative regulation of endocytic recycling ARHGAP10 332.49796797039 334.472534158325 330.523401782455 0.988192954659767 -0.0171353247866665 0.928925898216021 1 2.62586 3.01311 2.94909 2.78074 GeneID:79658,Genbank:XM_005263215.3,HGNC:HGNC:26099,MIM:609746 Rho GTPase activating protein 10 GO:0005096,GO:0005829,GO:0005886,GO:0007010,GO:0007165,GO:0043066,GO:0048471,GO:0051056 GTPase activator activity|cytosol|plasma membrane|cytoskeleton organization|signal transduction|negative regulation of apoptotic process|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction hsa05100 Bacterial invasion of epithelial cells ARHGAP11A 1171.12185214619 1273.90047138413 1068.34323290825 0.838639483151668 -0.253877341013338 0.446835591284959 1 8.22103 7.20123 8.30562 4.86446 GeneID:9824,Genbank:NM_001286479.2,HGNC:HGNC:15783,MIM:610589 Rho GTPase activating protein 11A GO:0005096,GO:0005829,GO:0007165,GO:0051056 GTPase activator activity|cytosol|signal transduction|regulation of small GTPase mediated signal transduction ARHGAP11B 157.312375424195 165.833187957764 148.791562890625 0.897236341669565 -0.156440038345664 0.539635488281082 1 3.42502 3.23629 3.42375 2.82015 GeneID:89839,Genbank:NM_001039841.2,HGNC:HGNC:15782,MIM:616310 Rho GTPase activating protein 11B GO:0005096,GO:0005829,GO:0007165,GO:0021987,GO:0051056 GTPase activator activity|cytosol|signal transduction|cerebral cortex development|regulation of small GTPase mediated signal transduction ARHGAP12 354.102660066838 359.685672720505 348.519647413171 0.968956157683794 -0.0454967053286468 0.923884768866312 1 2.71799 2.24762 3.0362 1.78268 GeneID:94134,Genbank:NM_001270698.1,HGNC:HGNC:16348,MIM:610577 Rho GTPase activating protein 12 GO:0001891,GO:0002011,GO:0005096,GO:0005829,GO:0006911,GO:0007015,GO:0007165,GO:0051056,GO:0051058 phagocytic cup|morphogenesis of an epithelial sheet|GTPase activator activity|cytosol|phagocytosis, engulfment|actin filament organization|signal transduction|regulation of small GTPase mediated signal transduction|negative regulation of small GTPase mediated signal transduction ARHGAP15 32.6765676426701 30.9411249073599 34.4120103779804 1.1121770937874 0.153386529056509 0.772524277794583 1 0.114746 0.109376 0.209355 0.0371717 GeneID:55843,Genbank:XM_011511479.2,HGNC:HGNC:21030,MIM:610578 Rho GTPase activating protein 15 GO:0005096,GO:0005829,GO:0007165,GO:0008360,GO:0016020,GO:0051056 GTPase activator activity|cytosol|signal transduction|regulation of cell shape|membrane|regulation of small GTPase mediated signal transduction ARHGAP17 1038.26081560284 1044.29442559043 1032.22720561524 0.988444618989165 -0.0167679586222333 0.907309872680933 1 7.34722 7.44664 7.57053 7.20623 GeneID:55114,Genbank:NM_018054.5,HGNC:HGNC:18239,MIM:608293 Rho GTPase activating protein 17 GO:0005096,GO:0005634,GO:0005829,GO:0005886,GO:0005923,GO:0007165,GO:0017124,GO:0051056 GTPase activator activity|nucleus|cytosol|plasma membrane|bicellular tight junction|signal transduction|SH3 domain binding|regulation of small GTPase mediated signal transduction hsa04530 Tight junction ARHGAP18 629.642762256887 616.103600799517 643.181923714258 1.04395092461658 0.0620538934437965 0.760212049276497 1 4.612 4.31241 5.31259 3.92944 GeneID:93663,Genbank:XM_005267213.1,HGNC:HGNC:21035,MIM:613351 Rho GTPase activating protein 18 GO:0005096,GO:0005737,GO:0005829,GO:0005886,GO:0007264,GO:0008360,GO:0016607,GO:0030833,GO:0032956,GO:0045296,GO:0051056,GO:2000145 GTPase activator activity|cytoplasm|cytosol|plasma membrane|small GTPase mediated signal transduction|regulation of cell shape|nuclear speck|regulation of actin filament polymerization|regulation of actin cytoskeleton organization|cadherin binding|regulation of small GTPase mediated signal transduction|regulation of cell motility ARHGAP19 844.97002491897 829.174731443073 860.765318394868 1.03809882978081 0.0539437986547425 0.710695413590767 1 6.02752 5.32352 6.61539 5.28744 GeneID:84986,Genbank:NM_001204300.1,HGNC:HGNC:23724,MIM:611587 Rho GTPase activating protein 19 GO:0005096,GO:0005634,GO:0005829,GO:0005886,GO:0007165,GO:0043231,GO:0051056 GTPase activator activity|nucleus|cytosol|plasma membrane|signal transduction|intracellular membrane-bounded organelle|regulation of small GTPase mediated signal transduction ARHGAP20 6.90334706276093 8.47529265732998 5.33140146819188 0.629052197221879 -0.66874836148905 0.59522509503731 1 0.0177052 0.0720988 0.0337893 0.0262726 GeneID:57569,Genbank:NM_001258418.1,HGNC:HGNC:18357,MIM:609568 Rho GTPase activating protein 20 ARHGAP21 856.767906954236 719.372362441864 994.163451466607 1.38198727581357 0.466744332654418 0.177951184480427 1 2.00259 1.85961 3.34539 2.07184 GeneID:57584,Genbank:NM_020824.3,HGNC:HGNC:23725,MIM:609870 Rho GTPase activating protein 21 GO:0000139,GO:0005096,GO:0005794,GO:0005829,GO:0005886,GO:0007030,GO:0007165,GO:0015629,GO:0030054,GO:0030659,GO:0043547,GO:0051056,GO:0051683,GO:0051684,GO:0072384 Golgi membrane|GTPase activator activity|Golgi apparatus|cytosol|plasma membrane|Golgi organization|signal transduction|actin cytoskeleton|cell junction|cytoplasmic vesicle membrane|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|establishment of Golgi localization|maintenance of Golgi location|organelle transport along microtubule ARHGAP22 301.921108990793 252.459139243776 351.38307873781 1.39184138783945 0.476994813187028 0.017515451099957 0.545445222117836 0.885465 0.955096 1.40751 1.081 GeneID:58504,Genbank:XM_011540013.3,HGNC:HGNC:30320,MIM:610585 Rho GTPase activating protein 22 GO:0001525,GO:0005096,GO:0005634,GO:0005829,GO:0005925,GO:0006351,GO:0006355,GO:0007165,GO:0030154,GO:0051056 angiogenesis|GTPase activator activity|nucleus|cytosol|focal adhesion|transcription, DNA-templated|regulation of transcription, DNA-templated|signal transduction|cell differentiation|regulation of small GTPase mediated signal transduction ARHGAP23 1080.01294429714 1057.06570800664 1102.96018058763 1.04341685879445 0.0613156487166141 0.708652835511718 1 5.29459 5.68824 5.65707 6.18134 GeneID:57636,Genbank:XM_006721991.1,HGNC:HGNC:29293,MIM:610590 Rho GTPase activating protein 23 GO:0005096,GO:0005829,GO:0007165,GO:0043547,GO:0051056,GO:0070062 GTPase activator activity|cytosol|signal transduction|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|extracellular exosome ARHGAP24 122.146364701797 78.0447974242048 166.24793197939 2.13016033696347 1.09096202605498 8.29931154627655e-05 0.0207690271445571 0.154462 0.156157 0.412135 0.295604 GeneID:83478,Genbank:NM_001025616.2,HGNC:HGNC:25361,MIM:610586 Rho GTPase activating protein 24 GO:0001525,GO:0005096,GO:0005829,GO:0005856,GO:0005925,GO:0007165,GO:0030154,GO:0042995,GO:0051056 angiogenesis|GTPase activator activity|cytosol|cytoskeleton|focal adhesion|signal transduction|cell differentiation|cell projection|regulation of small GTPase mediated signal transduction ARHGAP25 14.4298598142652 16.7486715608123 12.1110480677181 0.72310499514809 -0.467722952577156 0.544008632227741 1 0.0619071 0.102413 0.0458245 0.0915043 GeneID:9938,Genbank:XM_011533207.3,HGNC:HGNC:28951,MIM:610587 Rho GTPase activating protein 25 GO:0001891,GO:0005096,GO:0005829,GO:0006911,GO:0007015,GO:0007165,GO:0051056,GO:0051058 phagocytic cup|GTPase activator activity|cytosol|phagocytosis, engulfment|actin filament organization|signal transduction|regulation of small GTPase mediated signal transduction|negative regulation of small GTPase mediated signal transduction ARHGAP26 611.965418021243 653.473488862115 570.457347180371 0.872961729746223 -0.196009686754939 0.248605184181175 1 2.15069 1.95971 2.07346 1.56154 GeneID:23092,Genbank:XM_005268402.4,HGNC:HGNC:17073,MIM:605370 Rho GTPase activating protein 26 ARHGAP27 187.931462643143 195.093393251151 180.769532035136 0.92657946546875 -0.110013384666695 0.612923889628537 1 0.986933 1.21172 1.15011 1.0542 GeneID:201176,Genbank:NM_001282290.1,HGNC:HGNC:31813,MIM:610591 Rho GTPase activating protein 27 GO:0005096,GO:0005622,GO:0005634,GO:0005654,GO:0005829,GO:0006898,GO:0007165,GO:0016020,GO:0017124,GO:0043547 GTPase activator activity|intracellular|nucleus|nucleoplasm|cytosol|receptor-mediated endocytosis|signal transduction|membrane|SH3 domain binding|positive regulation of GTPase activity ARHGAP29 665.157369461508 714.730380105076 615.584358817939 0.861281926658049 -0.215442537154582 0.491364668568296 1 3.1495 2.66241 3.07316 1.91303 GeneID:9411,Genbank:NM_001328665.1,HGNC:HGNC:30207,MIM:610496 Rho GTPase activating protein 29 GO:0005096,GO:0005737,GO:0005829,GO:0007266,GO:0030165,GO:0046872,GO:0051056 GTPase activator activity|cytoplasm|cytosol|Rho protein signal transduction|PDZ domain binding|metal ion binding|regulation of small GTPase mediated signal transduction ARHGAP30 2.51152025102044 3.084507235799 1.93853326624189 0.628474215830372 -0.670074537921313 0.833675698800589 1 0.0239232 0.0217085 0.0150604 0.0140603 GeneID:257106,Genbank:XM_005245073.3,HGNC:HGNC:27414,MIM:614264 Rho GTPase activating protein 30 GO:0005096,GO:0005829,GO:0007264,GO:0031410,GO:0043231,GO:0051056 GTPase activator activity|cytosol|small GTPase mediated signal transduction|cytoplasmic vesicle|intracellular membrane-bounded organelle|regulation of small GTPase mediated signal transduction ARHGAP31 558.427158499874 537.704019143157 579.150297856591 1.07708009841451 0.107125541700602 0.530620602588152 1 2.25354 2.27175 2.57429 2.32499 GeneID:57514,Genbank:XM_006713714.3,HGNC:HGNC:29216,MIM:610911 Rho GTPase activating protein 31 GO:0005096,GO:0005829,GO:0005925,GO:0007264,GO:0017124,GO:0030027,GO:0051056 GTPase activator activity|cytosol|focal adhesion|small GTPase mediated signal transduction|SH3 domain binding|lamellipodium|regulation of small GTPase mediated signal transduction ARHGAP32 476.559567842965 452.884465985811 500.23466970012 1.10455250129024 0.143461994112771 0.653733485915597 1 1.24033 1.21019 1.72737 1.03652 GeneID:9743,Genbank:XM_017018595.2,HGNC:HGNC:17399,MIM:608541 Rho GTPase activating protein 32 GO:0000139,GO:0001650,GO:0005096,GO:0005654,GO:0005789,GO:0005794,GO:0005829,GO:0005938,GO:0007264,GO:0010008,GO:0014069,GO:0015629,GO:0030054,GO:0035091,GO:0043197,GO:0045211,GO:0051056 Golgi membrane|fibrillar center|GTPase activator activity|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|cell cortex|small GTPase mediated signal transduction|endosome membrane|postsynaptic density|actin cytoskeleton|cell junction|phosphatidylinositol binding|dendritic spine|postsynaptic membrane|regulation of small GTPase mediated signal transduction ARHGAP33 311.758939954575 276.510855559264 347.007024349885 1.25494900968006 0.327628746665145 0.103341290452126 1 1.30818 1.49131 1.86852 1.67497 GeneID:115703,Genbank:NM_052948.3,HGNC:HGNC:23085,MIM:614902 Rho GTPase activating protein 33 GO:0005096,GO:0005829,GO:0005886,GO:0005938,GO:0007264,GO:0015031,GO:0015629,GO:0019901,GO:0035091,GO:0043234,GO:0051056 GTPase activator activity|cytosol|plasma membrane|cell cortex|small GTPase mediated signal transduction|protein transport|actin cytoskeleton|protein kinase binding|phosphatidylinositol binding|protein complex|regulation of small GTPase mediated signal transduction ARHGAP35 4087.69209533402 3706.79271072779 4468.59147994026 1.20551426223748 0.269648719324978 0.0441571090808776 0.784836632957795 14.3079 14.0489 18.9948 15.6123 GeneID:2909,Genbank:XM_024451473.1,HGNC:HGNC:4591,MIM:605277 Rho GTPase activating protein 35 GO:0000122,GO:0000977,GO:0001227,GO:0001843,GO:0003677,GO:0003714,GO:0003924,GO:0005096,GO:0005525,GO:0005543,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0007165,GO:0007411,GO:0007413,GO:0008064,GO:0008360,GO:0010976,GO:0015629,GO:0016477,GO:0021955,GO:0030879,GO:0030900,GO:0030950,GO:0031668,GO:0032956,GO:0035024,GO:0036064,GO:0043010,GO:0043116,GO:0044319,GO:0045724,GO:0045892,GO:0050770,GO:0051056,GO:0097485 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|neural tube closure|DNA binding|transcription corepressor activity|GTPase activity|GTPase activator activity|GTP binding|phospholipid binding|nucleus|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|signal transduction|axon guidance|axonal fasciculation|regulation of actin polymerization or depolymerization|regulation of cell shape|positive regulation of neuron projection development|actin cytoskeleton|cell migration|central nervous system neuron axonogenesis|mammary gland development|forebrain development|establishment or maintenance of actin cytoskeleton polarity|cellular response to extracellular stimulus|regulation of actin cytoskeleton organization|negative regulation of Rho protein signal transduction|ciliary basal body|camera-type eye development|negative regulation of vascular permeability|wound healing, spreading of cells|positive regulation of cilium assembly|negative regulation of transcription, DNA-templated|regulation of axonogenesis|regulation of small GTPase mediated signal transduction|neuron projection guidance hsa04510,hsa04611,hsa04670,hsa04810 Focal adhesion|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton ARHGAP36 31.4519661059174 31.8830500916976 31.0208821201372 0.972958422450776 -0.0395499394243522 0.93953017028158 1 0.251747 0.442698 0.334573 0.324641 GeneID:158763,Genbank:NM_001282607.1,HGNC:HGNC:26388,MIM:300937 Rho GTPase activating protein 36 GO:0005096,GO:0005829,GO:0007165,GO:0051056 GTPase activator activity|cytosol|signal transduction|regulation of small GTPase mediated signal transduction ARHGAP39 250.77679355661 267.977727972141 233.575859141079 0.871624149173179 -0.198221926646316 0.347232325967321 1 1.2891 1.34488 1.11773 1.2013 GeneID:80728,Genbank:XM_011517308.1,HGNC:HGNC:29351,MIM:615880 Rho GTPase activating protein 39 GO:0005096,GO:0005634,GO:0005829,GO:0005856,GO:0007165,GO:0051056 GTPase activator activity|nucleus|cytosol|cytoskeleton|signal transduction|regulation of small GTPase mediated signal transduction ARHGAP4 23.5517269970243 18.507043414794 28.5964105792547 1.5451636405843 0.627759634866089 0.288875233320169 1 0.194995 0.153498 0.303603 0.245381 GeneID:393,Genbank:NM_001666.4,HGNC:HGNC:674,MIM:300023 Rho GTPase activating protein 4 GO:0005070,GO:0005096,GO:0005737,GO:0005794,GO:0005829,GO:0005874,GO:0007010,GO:0007266,GO:0010764,GO:0030336,GO:0030426,GO:0030517,GO:0042802,GO:0048365,GO:0051056 SH3/SH2 adaptor activity|GTPase activator activity|cytoplasm|Golgi apparatus|cytosol|microtubule|cytoskeleton organization|Rho protein signal transduction|negative regulation of fibroblast migration|negative regulation of cell migration|growth cone|negative regulation of axon extension|identical protein binding|Rac GTPase binding|regulation of small GTPase mediated signal transduction ARHGAP42 69.3734331706791 65.552881001846 73.1939853395122 1.11656397431947 0.159065913757182 0.680073127022322 1 0.231118 0.206239 0.317147 0.181118 GeneID:143872,Genbank:NM_152432.3,HGNC:HGNC:26545,MIM:615936 Rho GTPase activating protein 42 GO:0003085,GO:0005096,GO:0007165,GO:0035024,GO:0090630,GO:1904694 negative regulation of systemic arterial blood pressure|GTPase activator activity|signal transduction|negative regulation of Rho protein signal transduction|activation of GTPase activity|negative regulation of vascular smooth muscle contraction ARHGAP44 5.05042516112185 6.7071121482403 3.3937381740034 0.505990968839516 -0.982816459625325 0.504578158949251 1 0.0560453 0.0502774 0.0420212 0.0294282 GeneID:9912,Genbank:NM_001321167.1,HGNC:HGNC:29096,MIM:617716 Rho GTPase activating protein 44 GO:0005096,GO:0005543,GO:0005829,GO:0006887,GO:0007165,GO:0030054,GO:0031256,GO:0032956,GO:0035021,GO:0043197,GO:0048365,GO:0051056,GO:0055037,GO:0061001,GO:0098886,GO:0098887 GTPase activator activity|phospholipid binding|cytosol|exocytosis|signal transduction|cell junction|leading edge membrane|regulation of actin cytoskeleton organization|negative regulation of Rac protein signal transduction|dendritic spine|Rac GTPase binding|regulation of small GTPase mediated signal transduction|recycling endosome|regulation of dendritic spine morphogenesis|modification of dendritic spine|neurotransmitter receptor transport, endosome to postsynaptic membrane ARHGAP45 193.922448942443 210.486503464822 177.358394420065 0.842611718568958 -0.247060114658024 0.288786870591921 1 1.15442 1.08038 0.872773 0.985289 GeneID:23526,Genbank:NM_001258328.2,HGNC:HGNC:17102,MIM:601155 Rho GTPase activating protein 45 GO:0005096,GO:0005576,GO:0005829,GO:0016020,GO:0032587,GO:0034774,GO:0035556,GO:0035578,GO:0043312,GO:0046872,GO:0051056 GTPase activator activity|extracellular region|cytosol|membrane|ruffle membrane|secretory granule lumen|intracellular signal transduction|azurophil granule lumen|neutrophil degranulation|metal ion binding|regulation of small GTPase mediated signal transduction ARHGAP5 327.153010143714 320.826970142673 333.479050144755 1.03943583669557 0.0558007048647661 0.833077625054343 1 0.996118 0.896523 1.23354 0.769784 GeneID:394,Genbank:XM_005267636.4,HGNC:HGNC:675,MIM:602680 Rho GTPase activating protein 5 GO:0003924,GO:0005096,GO:0005525,GO:0005737,GO:0005783,GO:0005829,GO:0007155,GO:0007266,GO:0016020,GO:0030879,GO:0042169,GO:0051056 GTPase activity|GTPase activator activity|GTP binding|cytoplasm|endoplasmic reticulum|cytosol|cell adhesion|Rho protein signal transduction|membrane|mammary gland development|SH2 domain binding|regulation of small GTPase mediated signal transduction hsa04510,hsa04670 Focal adhesion|Leukocyte transendothelial migration ARHGAP6 6.88410917705327 9.88767193340919 3.88054642069736 0.392463104240492 -1.34937106338312 0.26689795137968 1 0.0831991 0.0480205 0.0497663 0 GeneID:395,Genbank:NM_013427.2,HGNC:HGNC:676,MIM:300118 Rho GTPase activating protein 6 GO:0005070,GO:0005096,GO:0005737,GO:0005829,GO:0005884,GO:0007202,GO:0007266,GO:0010518,GO:0015629,GO:0016004,GO:0017124,GO:0030041,GO:0043274,GO:0048041,GO:0051056,GO:0051497,GO:0051895 SH3/SH2 adaptor activity|GTPase activator activity|cytoplasm|cytosol|actin filament|activation of phospholipase C activity|Rho protein signal transduction|positive regulation of phospholipase activity|actin cytoskeleton|phospholipase activator activity|SH3 domain binding|actin filament polymerization|phospholipase binding|focal adhesion assembly|regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly ARHGAP9 3.02473481826688 4.11267631439867 1.93679332213509 0.470932593298016 -1.08640751970762 0.611816776500908 1 0.041759 0.0277848 0 0.0182041 GeneID:64333,Genbank:NM_001319850.1,HGNC:HGNC:14130,MIM:610576 Rho GTPase activating protein 9 GO:0005096,GO:0005547,GO:0005576,GO:0005829,GO:0007165,GO:0034774,GO:0043312,GO:0051056 GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|extracellular region|cytosol|signal transduction|secretory granule lumen|neutrophil degranulation|regulation of small GTPase mediated signal transduction ARHGDIA 12476.7361003507 12616.4920154157 12336.9801852857 0.977845519199114 -0.0323215298007618 0.784977802844521 1 181.032 184.671 183.545 181.598 GeneID:396,Genbank:NM_001185078.2,HGNC:HGNC:678,MIM:601925 Rho GDP dissociation inhibitor alpha GO:0005094,GO:0005096,GO:0005829,GO:0005856,GO:0006928,GO:0007162,GO:0035023,GO:0043066,GO:0050771,GO:0050772,GO:0051056,GO:0070062,GO:0071526,GO:2000249 Rho GDP-dissociation inhibitor activity|GTPase activator activity|cytosol|cytoskeleton|movement of cell or subcellular component|negative regulation of cell adhesion|regulation of Rho protein signal transduction|negative regulation of apoptotic process|negative regulation of axonogenesis|positive regulation of axonogenesis|regulation of small GTPase mediated signal transduction|extracellular exosome|semaphorin-plexin signaling pathway|regulation of actin cytoskeleton reorganization hsa04722,hsa04962 Neurotrophin signaling pathway|Vasopressin-regulated water reabsorption ARHGDIB 70.142719329669 85.5301386225121 54.755300036826 0.640187200894049 -0.643434261164236 0.066984600418539 0.912266462842959 1.48478 1.1686 0.834594 1.10031 GeneID:397,Genbank:NM_001175.6,HGNC:HGNC:679,MIM:602843 Rho GDP dissociation inhibitor beta GO:0003924,GO:0005094,GO:0005096,GO:0005737,GO:0005829,GO:0005856,GO:0006928,GO:0007162,GO:0007275,GO:0016020,GO:0031410,GO:0035023,GO:0048365,GO:0051056,GO:0070062,GO:0071461,GO:1901164,GO:2000249 GTPase activity|Rho GDP-dissociation inhibitor activity|GTPase activator activity|cytoplasm|cytosol|cytoskeleton|movement of cell or subcellular component|negative regulation of cell adhesion|multicellular organism development|membrane|cytoplasmic vesicle|regulation of Rho protein signal transduction|Rac GTPase binding|regulation of small GTPase mediated signal transduction|extracellular exosome|cellular response to redox state|negative regulation of trophoblast cell migration|regulation of actin cytoskeleton reorganization hsa04722,hsa04962 Neurotrophin signaling pathway|Vasopressin-regulated water reabsorption ARHGEF1 2108.75244682378 2134.17631721886 2083.32857642871 0.976174536105618 -0.0347889759290574 0.777117549567803 1 21.3994 23.2501 21.7341 22.8031 GeneID:9138,Genbank:NM_004706.3,HGNC:HGNC:681,MIM:601855 Rho guanine nucleotide exchange factor 1 GO:0003723,GO:0005085,GO:0005089,GO:0005096,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0007266,GO:0008283,GO:0035023,GO:0043065,GO:0051056 RNA binding|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|cytoplasm|cytosol|plasma membrane|G-protein coupled receptor signaling pathway|Rho protein signal transduction|cell proliferation|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction hsa04270,hsa04611,hsa04810,hsa04928,hsa05163,hsa05200,hsa05205 Vascular smooth muscle contraction|Platelet activation|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer ARHGEF10 1737.08986044651 1711.09589485476 1763.08382603825 1.03038282736801 0.0431804544294331 0.764225842120465 1 9.61007 9.69037 10.228 9.66271 GeneID:9639,Genbank:NM_001308153.1,HGNC:HGNC:14103,MIM:608136 Rho guanine nucleotide exchange factor 10 GO:0005089,GO:0005813,GO:0005829,GO:0019894,GO:0022011,GO:0035023,GO:0051298,GO:0051496,GO:0090307,GO:0090630 Rho guanyl-nucleotide exchange factor activity|centrosome|cytosol|kinesin binding|myelination in peripheral nervous system|regulation of Rho protein signal transduction|centrosome duplication|positive regulation of stress fiber assembly|mitotic spindle assembly|activation of GTPase activity ARHGEF10L 530.260175766785 505.158409860978 555.361941672591 1.09938175992246 0.136692448625375 0.435203211791081 1 1.84322 1.9587 2.00932 2.08785 GeneID:55160,Genbank:XM_024448061.1,HGNC:HGNC:25540,MIM:612494 Rho guanine nucleotide exchange factor 10 like GO:0005089,GO:0005737,GO:0035023 Rho guanyl-nucleotide exchange factor activity|cytoplasm|regulation of Rho protein signal transduction ARHGEF11 1411.85264797462 1410.46669639597 1413.23859955327 1.00196523828913 0.00283245721793344 0.988593737682246 1 3.97291 3.88993 4.33352 3.88957 GeneID:9826,Genbank:XM_006711663.3,HGNC:HGNC:14580,MIM:605708 Rho guanine nucleotide exchange factor 11 GO:0001558,GO:0001664,GO:0005085,GO:0005089,GO:0005096,GO:0005737,GO:0005829,GO:0006941,GO:0007186,GO:0007266,GO:0016020,GO:0030010,GO:0030036,GO:0035023,GO:0043065,GO:0045893,GO:0051056 regulation of cell growth|G-protein coupled receptor binding|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|cytoplasm|cytosol|striated muscle contraction|G-protein coupled receptor signaling pathway|Rho protein signal transduction|membrane|establishment of cell polarity|actin cytoskeleton organization|regulation of Rho protein signal transduction|positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|regulation of small GTPase mediated signal transduction hsa04270,hsa04928,hsa05163,hsa05200 Vascular smooth muscle contraction|Parathyroid hormone synthesis, secretion and action|Human cytomegalovirus infection|Pathways in cancer ARHGEF12 2623.79596901564 2516.15904105085 2731.43289698043 1.0855565377297 0.118434866052688 0.717603730782916 1 8.72759 7.86 11.3496 6.90115 GeneID:23365,Genbank:XM_017017420.1,HGNC:HGNC:14193,MIM:604763 Rho guanine nucleotide exchange factor 12 hsa04270,hsa04360,hsa04611,hsa04625,hsa04810,hsa05152,hsa05163,hsa05200,hsa05205 Vascular smooth muscle contraction|Axon guidance|Platelet activation|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Tuberculosis|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer ARHGEF16 26.1098208543868 34.7754522287568 17.4441894800168 0.501623655826729 -0.99532270978732 0.198160132264544 1 0.151394 0.361622 0.102859 0.131294 GeneID:27237,Genbank:NM_014448.3,HGNC:HGNC:15515 Rho guanine nucleotide exchange factor 16 GO:0005085,GO:0005089,GO:0005829,GO:0007186,GO:0017048,GO:0030165,GO:0030971,GO:0035023,GO:0043065,GO:0045296,GO:0051056,GO:0060326,GO:0090630,GO:1903078 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytosol|G-protein coupled receptor signaling pathway|Rho GTPase binding|PDZ domain binding|receptor tyrosine kinase binding|regulation of Rho protein signal transduction|positive regulation of apoptotic process|cadherin binding|regulation of small GTPase mediated signal transduction|cell chemotaxis|activation of GTPase activity|positive regulation of protein localization to plasma membrane ARHGEF17 861.771592583867 833.759895850922 889.783289316812 1.06719367739403 0.0938220243906697 0.560799038555742 1 3.12815 3.21297 3.44621 3.37903 GeneID:9828,Genbank:XM_017018623.1,HGNC:HGNC:21726,MIM:617043 Rho guanine nucleotide exchange factor 17 ARHGEF18 2219.23416093694 1992.98772718045 2445.48059469342 1.22704247564692 0.295185190601893 0.0346167831392195 0.730000079237491 8.3157 8.27216 10.8408 9.83916 GeneID:23370,Genbank:XM_006722706.3,HGNC:HGNC:17090,MIM:616432 Rho/Rac guanine nucleotide exchange factor 18 GO:0005085,GO:0005089,GO:0005829,GO:0005856,GO:0005886,GO:0007179,GO:0007186,GO:0007264,GO:0008360,GO:0016324,GO:0030036,GO:0030054,GO:0035023,GO:0043065,GO:0045177,GO:0051056,GO:0070062 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytosol|cytoskeleton|plasma membrane|transforming growth factor beta receptor signaling pathway|G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|regulation of cell shape|apical plasma membrane|actin cytoskeleton organization|cell junction|regulation of Rho protein signal transduction|positive regulation of apoptotic process|apical part of cell|regulation of small GTPase mediated signal transduction|extracellular exosome hsa04530 Tight junction ARHGEF19 89.8568339041534 100.72235208319 78.9913157251166 0.784248124585839 -0.350617920807576 0.256673338306528 1 1.10717 1.10331 0.908384 0.938047 GeneID:128272,Genbank:NM_153213.4,HGNC:HGNC:26604,MIM:612496 Rho guanine nucleotide exchange factor 19 GO:0005085,GO:0005089,GO:0005096,GO:0005829,GO:0007186,GO:0032956,GO:0035023,GO:0042060,GO:0043065,GO:0051056,GO:0060071 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|cytosol|G-protein coupled receptor signaling pathway|regulation of actin cytoskeleton organization|regulation of Rho protein signal transduction|wound healing|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction|Wnt signaling pathway, planar cell polarity pathway ARHGEF2 2751.98313295854 2797.54626966863 2706.41999624845 0.967426357015724 -0.0477762511103206 0.750004899905604 1 8.1083 8.4932 7.53912 8.81185 GeneID:9181,Genbank:NM_001350112.1,HGNC:HGNC:682,MIM:607560 Rho/Rac guanine nucleotide exchange factor 2 hsa04530,hsa05130,hsa05418 Tight junction|Pathogenic Escherichia coli infection|Fluid shear stress and atherosclerosis ARHGEF25 275.271663935508 263.154466192576 287.38886167844 1.09209190266271 0.12709426828777 0.568965511455642 1 3.10417 3.73353 3.80136 3.64553 GeneID:115557,Genbank:NM_001111270.2,HGNC:HGNC:30275,MIM:610215 Rho guanine nucleotide exchange factor 25 GO:0005089,GO:0005829,GO:0005886,GO:0007186,GO:0030016,GO:0030017,GO:0035023 Rho guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|G-protein coupled receptor signaling pathway|myofibril|sarcomere|regulation of Rho protein signal transduction ARHGEF26 164.748808364492 204.951639219236 124.545977509747 0.607684710325839 -0.718605101530942 0.00342982107104869 0.221500057556112 1.34664 1.37842 0.878687 0.83431 GeneID:26084,Genbank:NM_001251962.1,HGNC:HGNC:24490,MIM:617552 Rho guanine nucleotide exchange factor 26 GO:0001726,GO:0001886,GO:0005085,GO:0005089,GO:0005829,GO:0007186,GO:0035023,GO:0043065,GO:0051056,GO:0097178 ruffle|endothelial cell morphogenesis|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytosol|G-protein coupled receptor signaling pathway|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction|ruffle assembly hsa05100 Bacterial invasion of epithelial cells ARHGEF28 392.270287373651 382.258383175867 402.282191571434 1.05238291500426 0.0736597322569697 0.703375479699321 1 1.3666 1.45727 1.70761 1.29679 GeneID:64283,Genbank:NM_001080479.2,HGNC:HGNC:30322,MIM:612790 Rho guanine nucleotide exchange factor 28 GO:0003723,GO:0005085,GO:0005089,GO:0005829,GO:0005886,GO:0030154,GO:0035023,GO:0035556,GO:0046872,GO:0048013 RNA binding|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|cell differentiation|regulation of Rho protein signal transduction|intracellular signal transduction|metal ion binding|ephrin receptor signaling pathway ARHGEF3 393.338766801795 365.057857832674 421.619675770916 1.15493932461568 0.20781706084012 0.259954409700315 1 1.92933 1.94071 2.41123 2.33599 GeneID:50650,Genbank:NM_001128615.1,HGNC:HGNC:683,MIM:612115 Rho guanine nucleotide exchange factor 3 GO:0005085,GO:0005089,GO:0005622,GO:0005829,GO:0007186,GO:0007266,GO:0035023,GO:0043065,GO:0051056 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|intracellular|cytosol|G-protein coupled receptor signaling pathway|Rho protein signal transduction|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction ARHGEF33 2.4618623987038 2.49838328447175 2.42534151293585 0.970764385116615 -0.0428069142497335 1 1 0.00938624 0.0265204 0.0447589 0 GeneID:100271715,Genbank:NM_001145451.2,HGNC:HGNC:37252 Rho guanine nucleotide exchange factor 33 GO:0005089,GO:0035023 Rho guanyl-nucleotide exchange factor activity|regulation of Rho protein signal transduction ARHGEF35 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0150101 0 0 GeneID:445328,Genbank:NM_001003702.2,HGNC:HGNC:33846 Rho guanine nucleotide exchange factor 35 ARHGEF37 326.383142892761 230.175603437378 422.590682348144 1.83594905818554 0.876526029055267 8.24015210887116e-06 0.00399922049017213 1.51393 1.59137 2.86756 2.94853 GeneID:389337,Genbank:XM_011537642.3,HGNC:HGNC:34430 Rho guanine nucleotide exchange factor 37 GO:0005089,GO:0005737,GO:0007264,GO:0035023,GO:0043547 Rho guanyl-nucleotide exchange factor activity|cytoplasm|small GTPase mediated signal transduction|regulation of Rho protein signal transduction|positive regulation of GTPase activity ARHGEF39 640.785381023895 663.246507936794 618.324254110997 0.932269143842853 -0.101181577312072 0.554836813992671 1 5.34967 5.07795 4.63187 5.4696 GeneID:84904,Genbank:NM_032818.2,HGNC:HGNC:25909 Rho guanine nucleotide exchange factor 39 GO:0005089,GO:0005886,GO:0030335,GO:0035023 Rho guanyl-nucleotide exchange factor activity|plasma membrane|positive regulation of cell migration|regulation of Rho protein signal transduction ARHGEF4 805.344290489036 858.636850490307 752.051730487764 0.875867056088171 -0.191216188619836 0.347531651067948 1 2.38241 2.23566 1.78001 2.24242 GeneID:50649,Genbank:XM_011511274.3,HGNC:HGNC:684,MIM:605216 Rho guanine nucleotide exchange factor 4 GO:0005085,GO:0005089,GO:0005829,GO:0007186,GO:0019904,GO:0030032,GO:0030676,GO:0032587,GO:0035023,GO:0035556,GO:0043065,GO:0046847,GO:0051056 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytosol|G-protein coupled receptor signaling pathway|protein domain specific binding|lamellipodium assembly|Rac guanyl-nucleotide exchange factor activity|ruffle membrane|regulation of Rho protein signal transduction|intracellular signal transduction|positive regulation of apoptotic process|filopodium assembly|regulation of small GTPase mediated signal transduction hsa04810 Regulation of actin cytoskeleton ARHGEF40 1020.44288679057 1016.36137267971 1024.52440090142 1.00803161989538 0.0115408939477306 0.961335886004813 1 4.01847 4.46405 4.30165 4.01571 GeneID:55701,Genbank:XM_017021434.2,HGNC:HGNC:25516,MIM:610018 Rho guanine nucleotide exchange factor 40 GO:0005089,GO:0005737,GO:0035023 Rho guanyl-nucleotide exchange factor activity|cytoplasm|regulation of Rho protein signal transduction ARHGEF6 543.243170699635 576.130485248824 510.355856150446 0.885833798449373 -0.174892051462883 0.311934497798275 1 3.02146 3.01605 3.10611 2.4407 GeneID:9459,Genbank:XM_011531413.2,HGNC:HGNC:685,MIM:300267 Rac/Cdc42 guanine nucleotide exchange factor 6 GO:0005085,GO:0005089,GO:0005096,GO:0005829,GO:0006915,GO:0007186,GO:0007254,GO:0030027,GO:0030032,GO:0035023,GO:0043065,GO:0051056 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|cytosol|apoptotic process|G-protein coupled receptor signaling pathway|JNK cascade|lamellipodium|lamellipodium assembly|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction hsa04810,hsa05212 Regulation of actin cytoskeleton|Pancreatic cancer ARHGEF7 907.653438928239 928.927766378311 886.379111478168 0.954195948877671 -0.0676425336400773 0.661012180356852 1 2.94754 3.06118 2.89874 2.89651 GeneID:8874,Genbank:NM_001354046.1,HGNC:HGNC:15607,MIM:605477 Rho guanine nucleotide exchange factor 7 GO:0000322,GO:0001726,GO:0002244,GO:0005085,GO:0005089,GO:0005829,GO:0005886,GO:0005925,GO:0005938,GO:0007030,GO:0007165,GO:0007186,GO:0007399,GO:0010763,GO:0019901,GO:0030027,GO:0030032,GO:0032092,GO:0035023,GO:0035556,GO:0042059,GO:0043005,GO:0043025,GO:0043065,GO:0043234,GO:0043547,GO:0048013,GO:0048041,GO:0051056,GO:0060124,GO:1900026,GO:1904424,GO:2000394 storage vacuole|ruffle|hematopoietic progenitor cell differentiation|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|focal adhesion|cell cortex|Golgi organization|signal transduction|G-protein coupled receptor signaling pathway|nervous system development|positive regulation of fibroblast migration|protein kinase binding|lamellipodium|lamellipodium assembly|positive regulation of protein binding|regulation of Rho protein signal transduction|intracellular signal transduction|negative regulation of epidermal growth factor receptor signaling pathway|neuron projection|neuronal cell body|positive regulation of apoptotic process|protein complex|positive regulation of GTPase activity|ephrin receptor signaling pathway|focal adhesion assembly|regulation of small GTPase mediated signal transduction|positive regulation of growth hormone secretion|positive regulation of substrate adhesion-dependent cell spreading|regulation of GTP binding|positive regulation of lamellipodium morphogenesis hsa04810 Regulation of actin cytoskeleton ARHGEF9 454.112187934721 368.815749914917 539.408625954526 1.46254227504916 0.548478326660012 0.00241304922821531 0.178923131662484 0.819347 0.968505 1.41076 1.25754 GeneID:23229,Genbank:NM_001353922.1,HGNC:HGNC:14561,MIM:300429 Cdc42 guanine nucleotide exchange factor 9 GO:0005089,GO:0005737,GO:0035023 Rho guanyl-nucleotide exchange factor activity|cytoplasm|regulation of Rho protein signal transduction ARID1A 2323.93545498299 2317.74609419475 2330.12481577123 1.00534084454181 0.00768470674093121 0.968256513296637 1 9.32135 9.6045 9.97438 9.33593 GeneID:8289,Genbank:NM_006015.5,HGNC:HGNC:11110,MIM:603024 AT-rich interaction domain 1A GO:0000122,GO:0000790,GO:0001704,GO:0001843,GO:0003205,GO:0003408,GO:0003677,GO:0003713,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006344,GO:0006351,GO:0006357,GO:0007566,GO:0016514,GO:0016569,GO:0016922,GO:0019827,GO:0030520,GO:0030521,GO:0030900,GO:0031491,GO:0042766,GO:0042921,GO:0043044,GO:0045893,GO:0048096,GO:0055007,GO:0060674,GO:0071564,GO:0071565,GO:1901998 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|formation of primary germ layer|neural tube closure|cardiac chamber development|optic cup formation involved in camera-type eye development|DNA binding|transcription coactivator activity|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|maintenance of chromatin silencing|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|embryo implantation|SWI/SNF complex|covalent chromatin modification|ligand-dependent nuclear receptor binding|stem cell population maintenance|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|forebrain development|nucleosome binding|nucleosome mobilization|glucocorticoid receptor signaling pathway|ATP-dependent chromatin remodeling|positive regulation of transcription, DNA-templated|chromatin-mediated maintenance of transcription|cardiac muscle cell differentiation|placenta blood vessel development|npBAF complex|nBAF complex|toxin transport hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma ARID1B 1342.6135648251 1405.28661638254 1279.94051326767 0.910803887510488 -0.134787645661253 0.365429297745734 1 5.20286 4.73557 4.80015 4.38307 GeneID:57492,Genbank:XM_011535984.2,HGNC:HGNC:18040,MIM:614556 AT-rich interaction domain 1B GO:0002931,GO:0003677,GO:0003713,GO:0005654,GO:0005829,GO:0005886,GO:0006351,GO:0007270,GO:0007399,GO:0016514,GO:0016569,GO:0048096,GO:0060996,GO:0071565,GO:0097026,GO:1904385 response to ischemia|DNA binding|transcription coactivator activity|nucleoplasm|cytosol|plasma membrane|transcription, DNA-templated|neuron-neuron synaptic transmission|nervous system development|SWI/SNF complex|covalent chromatin modification|chromatin-mediated maintenance of transcription|dendritic spine development|nBAF complex|dendritic cell dendrite assembly|cellular response to angiotensin hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma ARID2 236.754515224132 253.94795375901 219.561076689255 0.864590848003498 -0.209910530004286 0.346683992863685 1 1.17227 0.954628 1.0764 0.782057 GeneID:196528,Genbank:XM_006719272.4,HGNC:HGNC:18037,MIM:609539 AT-rich interaction domain 2 GO:0003007,GO:0003677,GO:0005654,GO:0005886,GO:0006337,GO:0006351,GO:0006355,GO:0008285,GO:0016569,GO:0030336,GO:0042592,GO:0046872,GO:0048568,GO:0060038,GO:0060982 heart morphogenesis|DNA binding|nucleoplasm|plasma membrane|nucleosome disassembly|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of cell proliferation|covalent chromatin modification|negative regulation of cell migration|homeostatic process|metal ion binding|embryonic organ development|cardiac muscle cell proliferation|coronary artery morphogenesis hsa05225 Hepatocellular carcinoma ARID3A 107.691357001662 105.373126074231 110.009587929094 1.04400042048289 0.0621222929695322 0.856693689790197 1 0.543657 0.63449 0.66343 0.626906 GeneID:1820,Genbank:XM_017026445.1,HGNC:HGNC:3031,MIM:603265 AT-rich interaction domain 3A GO:0000977,GO:0001228,GO:0003682,GO:0005634,GO:0005654,GO:0005829,GO:0006977,GO:0042803,GO:0043231,GO:0045121 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|nucleus|nucleoplasm|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|protein homodimerization activity|intracellular membrane-bounded organelle|membrane raft ARID3B 147.334814600139 166.237015465459 128.432613734819 0.7725873408832 -0.372230056192296 0.140346731994124 1 1.2601 1.36751 1.20702 1.03553 GeneID:10620,Genbank:NM_001307939.1,HGNC:HGNC:14350,MIM:612457 AT-rich interaction domain 3B GO:0000977,GO:0000978,GO:0000980,GO:0001077,GO:0001205,GO:0001228,GO:0003677,GO:0005634,GO:0005654 RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|nucleus|nucleoplasm ARID3C 3.48078688414139 3.084507235799 3.87706653248377 1.25694843166074 0.329925462078687 0.933610977568463 1 0.0290296 0.0173312 0.0181443 0.016979 GeneID:138715,Genbank:XM_017014283.1,HGNC:HGNC:21209 AT-rich interaction domain 3C GO:0000977,GO:0001228,GO:0003682,GO:0005634,GO:0005737,GO:0045121 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|nucleus|cytoplasm|membrane raft ARID4A 39.6040362092486 38.9743724374174 40.2336999810798 1.03231168239295 0.0458786245918292 0.951140426409689 1 0.115877 0.140483 0.164816 0.108568 GeneID:5926,Genbank:XM_017021560.1,HGNC:HGNC:9885,MIM:180201 AT-rich interaction domain 4A GO:0003677,GO:0003700,GO:0004407,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006349,GO:0006357,GO:0006366,GO:0007283,GO:0017053,GO:0034773,GO:0036124,GO:0044212,GO:0045892,GO:0045944,GO:0048821,GO:0080182,GO:0097368 DNA binding|DNA binding transcription factor activity|histone deacetylase activity|nucleus|nucleoplasm|cytosol|plasma membrane|regulation of gene expression by genetic imprinting|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|spermatogenesis|transcriptional repressor complex|histone H4-K20 trimethylation|histone H3-K9 trimethylation|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|erythrocyte development|histone H3-K4 trimethylation|establishment of Sertoli cell barrier ARID4B 135.94006355763 147.796598634711 124.083528480549 0.83955604950848 -0.252301450905942 0.465894413468128 1 0.608722 0.512869 0.581405 0.395338 GeneID:51742,Genbank:XM_011544212.3,HGNC:HGNC:15550,MIM:609696 AT-rich interaction domain 4B GO:0004407,GO:0005634,GO:0005654,GO:0005737,GO:0006349,GO:0006351,GO:0006357,GO:0007283,GO:0034773,GO:0036124,GO:0044212,GO:0045944,GO:0097368 histone deacetylase activity|nucleus|nucleoplasm|cytoplasm|regulation of gene expression by genetic imprinting|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|spermatogenesis|histone H4-K20 trimethylation|histone H3-K9 trimethylation|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|establishment of Sertoli cell barrier ARID5A 178.296641176335 214.118917032371 142.474365320298 0.66539830900956 -0.587709895012574 0.0130482310336753 0.469619029742344 1.46285 1.53475 0.87391 1.04916 GeneID:10865,Genbank:NM_001319085.1,HGNC:HGNC:17361,MIM:611583 AT-rich interaction domain 5A GO:0000122,GO:0001227,GO:0003677,GO:0003714,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0008134,GO:0030331,GO:0043565,GO:0044212,GO:0045087,GO:0045892,GO:0046965,GO:0046966,GO:0050681,GO:0071391 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|transcription corepressor activity|RNA binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|transcription factor binding|estrogen receptor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|innate immune response|negative regulation of transcription, DNA-templated|retinoid X receptor binding|thyroid hormone receptor binding|androgen receptor binding|cellular response to estrogen stimulus ARID5B 778.98086942244 774.230933495765 783.730805349115 1.0122700752997 0.0175942547685101 0.914625456419855 1 2.6955 2.69542 3.14521 2.34137 GeneID:84159,Genbank:NM_032199.2,HGNC:HGNC:17362,MIM:608538 AT-rich interaction domain 5B GO:0000122,GO:0000977,GO:0001227,GO:0001822,GO:0001889,GO:0003677,GO:0003713,GO:0005634,GO:0005654,GO:0006351,GO:0008584,GO:0008585,GO:0009791,GO:0010761,GO:0030325,GO:0032452,GO:0035264,GO:0044212,GO:0045444,GO:0045892,GO:0048008,GO:0048468,GO:0048644,GO:0048705,GO:0051091,GO:0060021,GO:0060325,GO:0060612,GO:0060613,GO:1990830 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|kidney development|liver development|DNA binding|transcription coactivator activity|nucleus|nucleoplasm|transcription, DNA-templated|male gonad development|female gonad development|post-embryonic development|fibroblast migration|adrenal gland development|histone demethylase activity|multicellular organism growth|transcription regulatory region DNA binding|fat cell differentiation|negative regulation of transcription, DNA-templated|platelet-derived growth factor receptor signaling pathway|cell development|muscle organ morphogenesis|skeletal system morphogenesis|positive regulation of DNA binding transcription factor activity|palate development|face morphogenesis|adipose tissue development|fat pad development|cellular response to leukemia inhibitory factor ARIH1 1161.24047338555 1157.81443505259 1164.6665117185 1.00591811300538 0.00851286700284379 0.940462048493326 1 9.06392 8.60528 9.97874 7.84602 GeneID:25820,Genbank:NM_005744.3,HGNC:HGNC:689,MIM:605624 ariadne RBR E3 ubiquitin protein ligase 1 GO:0000151,GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0006511,GO:0008270,GO:0015030,GO:0016567,GO:0016604,GO:0019787,GO:0031624,GO:0031625,GO:0032436,GO:0042787,GO:0061630,GO:0097413 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|Cajal body|protein ubiquitination|nuclear body|ubiquitin-like protein transferase activity|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity|Lewy body ARIH2 4292.00960179997 4345.42404671054 4238.5951568894 0.975415773311695 -0.0359107927057412 0.77412641228159 1 14.3052 15.5554 15.28 14.6964 GeneID:10425,Genbank:NM_001349210.1,HGNC:HGNC:690,MIM:605615 ariadne RBR E3 ubiquitin protein ligase 2 GO:0000209,GO:0004842,GO:0005634,GO:0005654,GO:0005737,GO:0007275,GO:0008270,GO:0016567,GO:0031624,GO:0032436,GO:0042787,GO:0048588,GO:0061630,GO:0070534,GO:0070936,GO:0071425,GO:1903955 protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytoplasm|multicellular organism development|zinc ion binding|protein ubiquitination|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|developmental cell growth|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|hematopoietic stem cell proliferation|positive regulation of protein targeting to mitochondrion ARIH2OS 34.428325529094 32.0271289157524 36.8295221424356 1.14994766590898 0.201568205646518 0.720590326877205 1 0.703555 0.925678 1.03139 1.1047 GeneID:646450,Genbank:NM_001123040.1,HGNC:HGNC:34425 ariadne RBR E3 ubiquitin protein ligase 2 opposite strand GO:0016021 integral component of membrane ARL1 1211.68941632838 1329.12465232615 1094.25418033061 0.823289356957989 -0.28052851906471 0.0622527611222542 0.89180699654206 17.398 16.5653 13.6562 13.6838 GeneID:400,Genbank:NM_001301068.1,HGNC:HGNC:692,MIM:603425 ADP ribosylation factor like GTPase 1 GO:0003924,GO:0005525,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0007030,GO:0007264,GO:0008047,GO:0009404,GO:0019904,GO:0031584,GO:0032588,GO:0034067,GO:0042147,GO:0046872,GO:0048193,GO:0070062 GTPase activity|GTP binding|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|Golgi organization|small GTPase mediated signal transduction|enzyme activator activity|toxin metabolic process|protein domain specific binding|activation of phospholipase D activity|trans-Golgi network membrane|protein localization to Golgi apparatus|retrograde transport, endosome to Golgi|metal ion binding|Golgi vesicle transport|extracellular exosome ARL13B 132.09863351254 143.491817221573 120.705449803506 0.841200927974304 -0.249477653301755 0.595244596373075 1 1.35909 1.07836 1.33806 0.74783 GeneID:200894,Genbank:NM_001174150.1,HGNC:HGNC:25419,MIM:608922 ADP ribosylation factor like GTPase 13B GO:0001947,GO:0005525,GO:0005929,GO:0005930,GO:0007224,GO:0007264,GO:0009953,GO:0010226,GO:0021532,GO:0021830,GO:0021943,GO:0031514,GO:0060170,GO:0060271,GO:0070986,GO:1905515 heart looping|GTP binding|cilium|axoneme|smoothened signaling pathway|small GTPase mediated signal transduction|dorsal/ventral pattern formation|response to lithium ion|neural tube patterning|interneuron migration from the subpallium to the cortex|formation of radial glial scaffolds|motile cilium|ciliary membrane|cilium assembly|left/right axis specification|non-motile cilium assembly ARL14 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0279931 0 0.0260221 GeneID:80117,Genbank:NM_025047.2,HGNC:HGNC:22974,MIM:614439 ADP ribosylation factor like GTPase 14 GO:0005525,GO:0007264,GO:0031410 GTP binding|small GTPase mediated signal transduction|cytoplasmic vesicle ARL14EP 232.623129678923 237.459030881838 227.787228476009 0.959269595391207 -0.0599917642383671 0.801097036509854 1 2.75899 2.6128 2.67793 2.47104 GeneID:120534,Genbank:NM_152316.2,HGNC:HGNC:26798,MIM:612295 ADP ribosylation factor like GTPase 14 effector protein GO:0005634,GO:0005730,GO:0005829,GO:0005886,GO:0005925,GO:0043231 nucleus|nucleolus|cytosol|plasma membrane|focal adhesion|intracellular membrane-bounded organelle ARL14EPL 24.6480431142648 24.0899339350647 25.2061522934649 1.04633546781029 0.0653454712344017 0.949806340942252 1 0.420215 0.642138 0.750068 0.349392 GeneID:644100,Genbank:XM_017009722.1,HGNC:HGNC:44201 ADP ribosylation factor like GTPase 14 effector protein like ARL15 122.868341730976 150.246955644498 95.4897278174541 0.635551831368843 -0.653918308273087 0.0562044347339696 0.859761439063283 2.26212 1.73082 1.61143 0.945555 GeneID:54622,Genbank:XM_011543500.2,HGNC:HGNC:25945 ADP ribosylation factor like GTPase 15 GO:0005525,GO:0005622,GO:0007264,GO:0070062 GTP binding|intracellular|small GTPase mediated signal transduction|extracellular exosome ARL16 991.822237995206 1018.33146694265 965.31300904776 0.947935952471282 -0.0771385085207298 0.600836657167222 1 15.9758 16.7033 15.4548 17.2528 GeneID:339231,Genbank:NM_001040025.2,HGNC:HGNC:27902 ADP ribosylation factor like GTPase 16 GO:0005525,GO:0005622,GO:0007264 GTP binding|intracellular|small GTPase mediated signal transduction ARL17A 47.1768611037206 57.0295620698311 37.3241601376102 0.654470397158369 -0.611600156863033 0.221479777640482 1 0.316315 0.190741 0.231452 0.151156 GeneID:51326,Genbank:XM_005257439.5,HGNC:HGNC:24096 ADP ribosylation factor like GTPase 17A GO:0005525,GO:0005794,GO:0007264,GO:0015031,GO:0016192 GTP binding|Golgi apparatus|small GTPase mediated signal transduction|protein transport|vesicle-mediated transport ARL17B 22.7558157078678 41.6354348553051 3.87619656043037 0.093098500685804 -3.42509825583139 0.234154632915877 1 0.417922 0.0294795 0.0298248 0.0500132 GeneID:100506084,Genbank:NM_001103154.2,HGNC:HGNC:32387 ADP ribosylation factor like GTPase 17B GO:0005525,GO:0005794,GO:0007264,GO:0015031,GO:0016192 GTP binding|Golgi apparatus|small GTPase mediated signal transduction|protein transport|vesicle-mediated transport ARL2 1308.48614871572 1323.03614109713 1293.93615633432 0.978005147509672 -0.0320860363896753 0.79726301834169 1 56.9647 64.6037 61.4398 59.4832 GeneID:402,Genbank:NM_001667.3,HGNC:HGNC:693,MIM:601175 ADP ribosylation factor like GTPase 2 GO:0003924,GO:0005095,GO:0005525,GO:0005634,GO:0005730,GO:0005758,GO:0005759,GO:0005794,GO:0005813,GO:0005829,GO:0005925,GO:0007021,GO:0007098,GO:0007264,GO:0010811,GO:0016328,GO:0031113,GO:0031116,GO:0034260,GO:0050796,GO:0051457,GO:0070062,GO:0070830 GTPase activity|GTPase inhibitor activity|GTP binding|nucleus|nucleolus|mitochondrial intermembrane space|mitochondrial matrix|Golgi apparatus|centrosome|cytosol|focal adhesion|tubulin complex assembly|centrosome cycle|small GTPase mediated signal transduction|positive regulation of cell-substrate adhesion|lateral plasma membrane|regulation of microtubule polymerization|positive regulation of microtubule polymerization|negative regulation of GTPase activity|regulation of insulin secretion|maintenance of protein location in nucleus|extracellular exosome|bicellular tight junction assembly ARL2BP 1829.33332665206 1921.40889353021 1737.25775977392 0.90415827969967 -0.145352745532864 0.309541218371061 1 43.3062 43.2084 36.3049 41.9716 GeneID:23568,Genbank:NM_012106.3,HGNC:HGNC:17146,MIM:615407 ADP ribosylation factor like GTPase 2 binding protein GO:0003713,GO:0005634,GO:0005758,GO:0005759,GO:0005813,GO:0005819,GO:0005829,GO:0005929,GO:0007165,GO:0030496,GO:0030695,GO:0042531,GO:0050796,GO:0051457 transcription coactivator activity|nucleus|mitochondrial intermembrane space|mitochondrial matrix|centrosome|spindle|cytosol|cilium|signal transduction|midbody|GTPase regulator activity|positive regulation of tyrosine phosphorylation of STAT protein|regulation of insulin secretion|maintenance of protein location in nucleus ARL3 819.929418671557 852.910898146836 786.947939196279 0.922661371669797 -0.116126837104516 0.552964326732445 1 6.79462 7.44247 6.15446 7.38937 GeneID:403,Genbank:NM_004311.3,HGNC:HGNC:694,MIM:604695 ADP ribosylation factor like GTPase 3 GO:0000139,GO:0000281,GO:0001822,GO:0003924,GO:0005525,GO:0005634,GO:0005794,GO:0005813,GO:0005876,GO:0005881,GO:0005929,GO:0006892,GO:0007224,GO:0007264,GO:0008017,GO:0019003,GO:0030496,GO:0032391,GO:0042073,GO:0042461,GO:0046872,GO:0060271,GO:0070062 Golgi membrane|mitotic cytokinesis|kidney development|GTPase activity|GTP binding|nucleus|Golgi apparatus|centrosome|spindle microtubule|cytoplasmic microtubule|cilium|post-Golgi vesicle-mediated transport|smoothened signaling pathway|small GTPase mediated signal transduction|microtubule binding|GDP binding|midbody|photoreceptor connecting cilium|intraciliary transport|photoreceptor cell development|metal ion binding|cilium assembly|extracellular exosome ARL4A 1075.9794037527 1085.27609290951 1066.68271459589 0.982867605363196 -0.0249309997353448 0.881782743383564 1 14.2276 14.062 14.8664 13.1761 GeneID:10124,Genbank:NM_001037164.2,HGNC:HGNC:695,MIM:604786 ADP ribosylation factor like GTPase 4A GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0007264,GO:0050873 GTP binding|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|small GTPase mediated signal transduction|brown fat cell differentiation ARL4C 5413.20704407854 5139.39007245184 5687.02401570524 1.10655621300061 0.146076741836877 0.272317413638936 1 61.8577 63.084 77.3059 62.7846 GeneID:10123,Genbank:NM_001282431.1,HGNC:HGNC:698,MIM:604787 ADP ribosylation factor like GTPase 4C GO:0003924,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007264,GO:0030175,GO:0032456,GO:0043014 GTPase activity|GTP binding|nucleus|cytoplasm|cytosol|plasma membrane|small GTPase mediated signal transduction|filopodium|endocytic recycling|alpha-tubulin binding ARL4D 128.544358213484 130.145236509993 126.943479916975 0.975398587924709 -0.0359362110880067 0.933984907399635 1 3.5855 3.41447 2.46487 3.98433 GeneID:379,Genbank:NM_001661.3,HGNC:HGNC:656,MIM:600732 ADP ribosylation factor like GTPase 4D GO:0005525,GO:0005730,GO:0005737,GO:0005886,GO:0007264 GTP binding|nucleolus|cytoplasm|plasma membrane|small GTPase mediated signal transduction ARL5A 479.458663882437 489.312428864071 469.604898900803 0.959724035604371 -0.0593084699912392 0.754079082486102 1 7.36643 7.43973 7.4324 6.93178 GeneID:26225,Genbank:NM_177985.2,HGNC:HGNC:696,MIM:608960 ADP ribosylation factor like GTPase 5A GO:0005525,GO:0005622,GO:0007264,GO:1903292 GTP binding|intracellular|small GTPase mediated signal transduction|protein localization to Golgi membrane ARL5B 173.878455462362 191.68149374681 156.075417177914 0.814243535602198 -0.296467733986382 0.221568798744962 1 1.25433 1.23856 1.22405 0.782304 GeneID:221079,Genbank:NM_178815.4,HGNC:HGNC:23052,MIM:608909 ADP ribosylation factor like GTPase 5B GO:0005525,GO:0005622,GO:0007264,GO:1903292 GTP binding|intracellular|small GTPase mediated signal transduction|protein localization to Golgi membrane ARL6 72.8942385666591 84.2422208602718 61.5462562730464 0.730586820296796 -0.452872367007251 0.389477081554231 1 0.578949 0.323765 0.342392 0.305759 GeneID:84100,Genbank:XM_017007312.2,HGNC:HGNC:13210,MIM:608845 ADP ribosylation factor like GTPase 6 GO:0005525,GO:0005543,GO:0005737,GO:0005829,GO:0005879,GO:0005886,GO:0005929,GO:0005930,GO:0006612,GO:0007264,GO:0007368,GO:0007420,GO:0007601,GO:0008589,GO:0010842,GO:0016020,GO:0016055,GO:0030117,GO:0032402,GO:0045444,GO:0046872,GO:0051258,GO:0060271,GO:0061512,GO:0070062,GO:0097499,GO:1903445 GTP binding|phospholipid binding|cytoplasm|cytosol|axonemal microtubule|plasma membrane|cilium|axoneme|protein targeting to membrane|small GTPase mediated signal transduction|determination of left/right symmetry|brain development|visual perception|regulation of smoothened signaling pathway|retina layer formation|membrane|Wnt signaling pathway|membrane coat|melanosome transport|fat cell differentiation|metal ion binding|protein polymerization|cilium assembly|protein localization to cilium|extracellular exosome|protein localization to non-motile cilium|protein transport from ciliary membrane to plasma membrane ARL6IP1 7765.58526935687 8085.90381030355 7445.2667284102 0.92077112257049 -0.119085506831681 0.380249770943875 1 155.52 140.754 150.554 125.036 GeneID:23204,Genbank:NM_015161.2,HGNC:HGNC:697,MIM:607669 ADP ribosylation factor like GTPase 6 interacting protein 1 GO:0002038,GO:0005784,GO:0005789,GO:0006613,GO:0006915,GO:0016020,GO:0030176,GO:0042802,GO:0043066,GO:0043154,GO:0071787,GO:1990809 positive regulation of L-glutamate transport|Sec61 translocon complex|endoplasmic reticulum membrane|cotranslational protein targeting to membrane|apoptotic process|membrane|integral component of endoplasmic reticulum membrane|identical protein binding|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|endoplasmic reticulum tubular network formation|endoplasmic reticulum tubular network membrane organization ARL6IP4 2248.99296190167 2192.8005550084 2305.18536879495 1.05125172625931 0.0721081695303107 0.692718400649617 1 25.3197 26.1133 27.6004 30.2736 GeneID:51329,Genbank:NM_001278380.1,HGNC:HGNC:18076,MIM:607668 ADP ribosylation factor like GTPase 6 interacting protein 4 GO:0003723,GO:0005634,GO:0005730,GO:0006397,GO:0008380,GO:0016607 RNA binding|nucleus|nucleolus|mRNA processing|RNA splicing|nuclear speck ARL6IP5 4201.53128443844 4229.47700419879 4173.58556467808 0.986785259864229 -0.0191919293907994 0.892494421261675 1 88.1613 91.0797 90.5209 87.217 GeneID:10550,Genbank:NM_006407.3,HGNC:HGNC:16937,MIM:605709 ADP ribosylation factor like GTPase 6 interacting protein 5 GO:0002037,GO:0005789,GO:0005856,GO:0005886,GO:0008631,GO:0010917,GO:0015813,GO:0016020,GO:0016021,GO:0032874,GO:0043065,GO:0043280,GO:0070062 negative regulation of L-glutamate transport|endoplasmic reticulum membrane|cytoskeleton|plasma membrane|intrinsic apoptotic signaling pathway in response to oxidative stress|negative regulation of mitochondrial membrane potential|L-glutamate transport|membrane|integral component of membrane|positive regulation of stress-activated MAPK cascade|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|extracellular exosome ARL6IP6 915.911419375549 960.39819730806 871.424641443038 0.907357639659873 -0.140256786399005 0.352811613305112 1 13.0862 15.3905 14.7081 11.5193 GeneID:151188,Genbank:NM_152522.5,HGNC:HGNC:24048,MIM:616495 ADP ribosylation factor like GTPase 6 interacting protein 6 GO:0016021 integral component of membrane ARL8A 1039.23714471938 1078.2720314589 1000.20225797985 0.927597330542435 -0.108429426713205 0.471226397678429 1 22.4373 22.138 19.8425 22.1674 GeneID:127829,Genbank:NM_001256129.1,HGNC:HGNC:25192,MIM:616597 ADP ribosylation factor like GTPase 8A GO:0005525,GO:0005737,GO:0005765,GO:0007049,GO:0007059,GO:0007264,GO:0030496,GO:0031902,GO:0051233,GO:0051301 GTP binding|cytoplasm|lysosomal membrane|cell cycle|chromosome segregation|small GTPase mediated signal transduction|midbody|late endosome membrane|spindle midzone|cell division ARL8B 1877.1912617968 1898.63325232014 1855.74927127347 0.977413236076914 -0.0329594532726674 0.846508680802336 1 33.707 30.7685 34.7886 28.8014 GeneID:55207,Genbank:NM_018184.2,HGNC:HGNC:25564,MIM:616596 ADP ribosylation factor like GTPase 8B GO:0003924,GO:0005525,GO:0005737,GO:0005765,GO:0007049,GO:0007059,GO:0007264,GO:0016020,GO:0019003,GO:0030496,GO:0031902,GO:0032418,GO:0043014,GO:0048487,GO:0051233,GO:0051301,GO:0070062 GTPase activity|GTP binding|cytoplasm|lysosomal membrane|cell cycle|chromosome segregation|small GTPase mediated signal transduction|membrane|GDP binding|midbody|late endosome membrane|lysosome localization|alpha-tubulin binding|beta-tubulin binding|spindle midzone|cell division|extracellular exosome ARL9 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0 0 GeneID:132946,Genbank:NM_206919.1,HGNC:HGNC:23592,MIM:612405 ADP ribosylation factor like GTPase 9 GO:0005525,GO:0005622,GO:0007264 GTP binding|intracellular|small GTPase mediated signal transduction ARMC1 848.498183047284 827.032149391611 869.964216702956 1.05191100169797 0.0730126486982328 0.626582843700711 1 10.5539 10.2334 12.1427 9.89245 GeneID:55156,Genbank:NM_001286702.1,HGNC:HGNC:17684 armadillo repeat containing 1 GO:0005634,GO:0005737,GO:0005739,GO:0030001,GO:0046872 nucleus|cytoplasm|mitochondrion|metal ion transport|metal ion binding ARMC10 1046.23101734023 1085.91126013637 1006.5507745441 0.926918074703167 -0.109486262447065 0.465944745685589 1 6.81597 7.18695 6.64343 6.58697 GeneID:83787,Genbank:NM_031905.4,HGNC:HGNC:21706,MIM:611864 armadillo repeat containing 10 GO:0002039,GO:0005739,GO:0005783,GO:0005789,GO:0016021,GO:0040008,GO:0040010,GO:0043066,GO:0050692,GO:1902254 p53 binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|regulation of growth|positive regulation of growth rate|negative regulation of apoptotic process|DBD domain binding|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator ARMC12 12.2431135574026 11.4059124139662 13.080314700839 1.14680125763745 0.197615391820753 0.842006992835868 1 0.113898 0.0903217 0.0806935 0.150244 GeneID:221481,Genbank:XM_011514381.2,HGNC:HGNC:21099 armadillo repeat containing 12 GO:0005634 nucleus ARMC2 56.7251235114499 58.2116186275935 55.2386283953064 0.948927889270582 -0.0756296364549753 0.879587507074106 1 0.293493 0.25198 0.275334 0.319897 GeneID:84071,Genbank:XM_017011350.1,HGNC:HGNC:23045 armadillo repeat containing 2 ARMC3 1.45302997762802 0 2.90605995525603 Inf Inf 0.254745368186766 1 0 0 0.00966883 0.0269815 GeneID:219681,Genbank:NM_173081.4,HGNC:HGNC:30964,MIM:611226 armadillo repeat containing 3 GO:0005634,GO:0005737,GO:0070062 nucleus|cytoplasm|extracellular exosome ARMC4 46.4729193552411 46.9017587629972 46.0440799474851 0.981713290969618 -0.0266263474260303 0.991572779811319 1 0.1887 0.164845 0.232144 0.194981 GeneID:55130,Genbank:NM_018076.4,HGNC:HGNC:25583,MIM:615408 armadillo repeat containing 4 GO:0003341,GO:0003356,GO:0005634,GO:0005737,GO:0005930,GO:0007368,GO:0007507,GO:0021591,GO:0036158,GO:0097546 cilium movement|regulation of cilium beat frequency|nucleus|cytoplasm|axoneme|determination of left/right symmetry|heart development|ventricular system development|outer dynein arm assembly|ciliary base ARMC5 275.673635329372 270.255597193404 281.09167346534 1.0400956590149 0.0567162210970299 0.823733485302759 1 2.48485 2.89757 3.07621 2.66269 GeneID:79798,Genbank:XM_024450448.1,HGNC:HGNC:25781,MIM:615549 armadillo repeat containing 5 GO:0005654,GO:0005737,GO:0005829,GO:0005925 nucleoplasm|cytoplasm|cytosol|focal adhesion hsa04934 Cushing syndrome ARMC6 2224.10079583066 2285.87386975901 2162.32772190231 0.945952333813709 -0.0801606063577264 0.548898244624084 1 28.8273 31.0244 27.8935 29.8523 GeneID:93436,Genbank:NM_001199196.1,HGNC:HGNC:25049 armadillo repeat containing 6 GO:0002244,GO:0005829 hematopoietic progenitor cell differentiation|cytosol ARMC7 572.372846079686 570.472176490254 574.273515669117 1.00666349619757 0.00958150509352676 0.997371404500606 1 7.52103 8.94796 8.23892 8.19108 GeneID:79637,Genbank:NM_024585.3,HGNC:HGNC:26168 armadillo repeat containing 7 GO:0005634,GO:0005737,GO:0016342,GO:0019903,GO:0045294,GO:0045296 nucleus|cytoplasm|catenin complex|protein phosphatase binding|alpha-catenin binding|cadherin binding ARMC8 427.900108541332 443.851458341622 411.948758741042 0.928123026294022 -0.107612042055733 0.58376406368797 1 2.33969 2.01714 2.10204 1.91273 GeneID:25852,Genbank:NM_015396.5,HGNC:HGNC:24999 armadillo repeat containing 8 GO:0005576,GO:0035580,GO:0043312,GO:1904724 extracellular region|specific granule lumen|neutrophil degranulation|tertiary granule lumen ARMC9 409.858087074493 432.494589203196 387.22158494579 0.895321223923716 -0.159522708580537 0.381524316295743 1 0.676247 0.707126 0.611483 0.599025 GeneID:80210,Genbank:NM_001352754.1,HGNC:HGNC:20730,MIM:617612 armadillo repeat containing 9 GO:0070062 extracellular exosome ARMCX1 104.092827966128 118.047338940222 90.1383169920341 0.763577712138682 -0.38915310196252 0.186328563417495 1 2.07139 2.10085 1.56726 1.56171 GeneID:51309,Genbank:NM_016608.1,HGNC:HGNC:18073,MIM:300362 armadillo repeat containing, X-linked 1 ARMCX2 487.091589265454 493.886767615958 480.296410914949 0.972482849122257 -0.0402552881864311 0.822461143486764 1 4.89972 4.91203 5.43018 4.59112 GeneID:9823,Genbank:NM_014782.6,HGNC:HGNC:16869,MIM:300363 armadillo repeat containing, X-linked 2 ARMCX3 914.334447967295 905.383704773287 923.285191161302 1.01977226483494 0.0282470060432038 0.844750440115303 1 4.67242 4.015 5.05088 4.05937 GeneID:51566,Genbank:NM_016607.3,HGNC:HGNC:24065,MIM:300364 armadillo repeat containing, X-linked 3 ARMCX4 88.2770570409775 90.2867738180309 86.2673402639241 0.955481479909696 -0.0657001851606979 0.851823379826052 1 0.420359 0.422396 0.447065 0.378363 GeneID:100131755,Genbank:NM_001256155.2,HGNC:HGNC:28615 armadillo repeat containing, X-linked 4 GO:0016021 integral component of membrane ARMCX5 184.535096260149 173.270502881386 195.799689638911 1.13002320869899 0.17635240337594 0.448893996275703 1 2.41166 2.20285 2.74397 2.39196 GeneID:64860,Genbank:NM_001168479.1,HGNC:HGNC:25772 armadillo repeat containing, X-linked 5 ARMCX5-GPRASP2 12.0990347333478 11.1177547658566 13.080314700839 1.17652484483734 0.234531786473957 0.843323035012215 1 0.863678 0.717594 0.75381 0.827229 GeneID:100528062,Genbank:NM_001199818.1,HGNC:HGNC:42000 ARMCX5-GPRASP2 readthrough GO:0001540,GO:0005737 amyloid-beta binding|cytoplasm ARMCX6 465.41662689524 448.675737122042 482.157516668439 1.07462355722901 0.103831369367386 0.578833209909059 1 4.05095 3.65389 4.38767 4.72706 GeneID:54470,Genbank:NM_001009584.1,HGNC:HGNC:26094 armadillo repeat containing, X-linked 6 GO:0005741,GO:0016021 mitochondrial outer membrane|integral component of membrane ARMH1 3.55532784585389 3.71865746181119 3.3919982298966 0.912156676093666 -0.132646445486615 1 1 0.0473506 0 0.0222938 0.0103951 GeneID:339541,Genbank:XM_017001145.1,HGNC:HGNC:34345 armadillo-like helical domain containing 1 ARMH3 935.750113577872 906.154159169955 965.346067985789 1.06532211789444 0.0912897193001315 0.557506481336228 1 5.32131 5.66694 5.89755 6.06573 GeneID:79591,Genbank:NM_024541.2,HGNC:HGNC:25788 armadillo-like helical domain containing 3 GO:0016021 integral component of membrane ARMH4 109.493801808788 96.8399984871084 122.147605130467 1.26133423212236 0.334950615977825 0.293430464907707 1 0.212651 0.210788 0.30316 0.239967 GeneID:145407,Genbank:XM_017021030.2,HGNC:HGNC:19846 armadillo-like helical domain containing 4 GO:0016021 integral component of membrane ARMT1 507.918161641898 564.127623227567 451.708700056228 0.800720761504016 -0.320628881254618 0.182482694624947 1 11.4874 9.39603 9.34717 7.22056 GeneID:79624,Genbank:NM_024573.2,HGNC:HGNC:17872,MIM:616332 acidic residue methyltransferase 1 GO:0006974,GO:0008757,GO:0019899,GO:0032259,GO:0051998,GO:2001020 cellular response to DNA damage stimulus|S-adenosylmethionine-dependent methyltransferase activity|enzyme binding|methylation|protein carboxyl O-methyltransferase activity|regulation of response to DNA damage stimulus ARNT 893.558224504368 875.981454657555 911.134994351181 1.04013046110362 0.0567644935423373 0.715154556258471 1 5.74567 5.81783 6.3159 5.57912 GeneID:405,Genbank:NM_001197325.1,HGNC:HGNC:700,MIM:126110 aryl hydrocarbon receptor nuclear translocator hsa04066,hsa04934,hsa05200,hsa05204,hsa05211 HIF-1 signaling pathway|Cushing syndrome|Pathways in cancer|Chemical carcinogenesis|Renal cell carcinoma ARNT2 991.259546009749 870.764174025402 1111.7549179941 1.27675776192609 0.35248482980282 0.0216528083655694 0.600929980812952 4.76112 4.8938 6.49653 6.00724 GeneID:9915,Genbank:NM_014862.3,HGNC:HGNC:16876,MIM:606036 aryl hydrocarbon receptor nuclear translocator 2 GO:0000978,GO:0000981,GO:0001077,GO:0001666,GO:0001701,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006355,GO:0006805,GO:0007417,GO:0007420,GO:0008284,GO:0017162,GO:0032355,GO:0043066,GO:0045893,GO:0045944,GO:0046982 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|response to hypoxia|in utero embryonic development|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|cytoplasm|regulation of transcription, DNA-templated|xenobiotic metabolic process|central nervous system development|brain development|positive regulation of cell proliferation|aryl hydrocarbon receptor binding|response to estradiol|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity hsa05200,hsa05202,hsa05211 Pathways in cancer|Transcriptional misregulation in cancer|Renal cell carcinoma ARNTL 313.143013584409 336.009374948243 290.276652220574 0.863894503733078 -0.211072949435872 0.297617263294024 1 2.32134 1.96827 1.7278 1.91799 GeneID:406,Genbank:XM_017017739.2,HGNC:HGNC:701,MIM:602550 aryl hydrocarbon receptor nuclear translocator like GO:0000976,GO:0001047,GO:0003677,GO:0003700,GO:0005634,GO:0005667,GO:0006351,GO:0006355,GO:0007283,GO:0016605,GO:0032007,GO:0032922,GO:0033391,GO:0042634,GO:0042753,GO:0043161,GO:0043565,GO:0045599,GO:0045892,GO:0045893,GO:0046983,GO:0050767,GO:0050796,GO:0051726,GO:0051775,GO:0070888,GO:0090263,GO:0090403,GO:1901985,GO:2000074,GO:2000323,GO:2000772,GO:2001016 transcription regulatory region sequence-specific DNA binding|core promoter binding|DNA binding|DNA binding transcription factor activity|nucleus|transcription factor complex|transcription, DNA-templated|regulation of transcription, DNA-templated|spermatogenesis|PML body|negative regulation of TOR signaling|circadian regulation of gene expression|chromatoid body|regulation of hair cycle|positive regulation of circadian rhythm|proteasome-mediated ubiquitin-dependent protein catabolic process|sequence-specific DNA binding|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|regulation of neurogenesis|regulation of insulin secretion|regulation of cell cycle|response to redox state|E-box binding|positive regulation of canonical Wnt signaling pathway|oxidative stress-induced premature senescence|positive regulation of protein acetylation|regulation of type B pancreatic cell development|negative regulation of glucocorticoid receptor signaling pathway|regulation of cellular senescence|positive regulation of skeletal muscle cell differentiation hsa04710,hsa04728,hsa05168 Circadian rhythm|Dopaminergic synapse|Herpes simplex infection ARNTL2 652.801693698678 726.915538569964 578.687848827392 0.796086777792403 -0.329002393933635 0.0477032210576893 0.802536542499949 3.01101 2.7774 2.64579 2.10109 GeneID:56938,Genbank:NM_001248003.1,HGNC:HGNC:18984,MIM:614517 aryl hydrocarbon receptor nuclear translocator like 2 GO:0000982,GO:0003700,GO:0005634,GO:0005667,GO:0005730,GO:0005737,GO:0006351,GO:0006355,GO:0006357,GO:0007623,GO:0009649,GO:0042753,GO:0045893,GO:0045944,GO:0046983,GO:0070888 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription factor complex|nucleolus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|circadian rhythm|entrainment of circadian clock|positive regulation of circadian rhythm|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|E-box binding ARPC1A 5181.75322998253 4757.09550565811 5606.41095430695 1.17853655610628 0.23699650911442 0.0767774997084145 0.94157495521624 126.565 132.462 149.819 158.598 GeneID:10552,Genbank:NM_006409.3,HGNC:HGNC:703,MIM:604220 actin related protein 2/3 complex subunit 1A GO:0003779,GO:0005829,GO:0005885,GO:0015629,GO:0030036,GO:0034314,GO:0036195,GO:0038096,GO:0048013,GO:0051015,GO:0061024,GO:0070062 actin binding|cytosol|Arp2/3 protein complex|actin cytoskeleton|actin cytoskeleton organization|Arp2/3 complex-mediated actin nucleation|muscle cell projection membrane|Fc-gamma receptor signaling pathway involved in phagocytosis|ephrin receptor signaling pathway|actin filament binding|membrane organization|extracellular exosome hsa04144,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132 Endocytosis|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection ARPC1B 4082.40905944332 4427.62177207044 3737.1963468162 0.844064045937831 -0.244575622908349 0.0920005466763101 0.985009977016794 95.9023 100.475 79.8108 90.8099 GeneID:10095,Genbank:XM_024446628.1,HGNC:HGNC:704,MIM:604223 actin related protein 2/3 complex subunit 1B GO:0003779,GO:0005200,GO:0005829,GO:0005885,GO:0005925,GO:0006928,GO:0015629,GO:0032355,GO:0032403,GO:0034314,GO:0036284,GO:0038096,GO:0043627,GO:0048013,GO:0070062 actin binding|structural constituent of cytoskeleton|cytosol|Arp2/3 protein complex|focal adhesion|movement of cell or subcellular component|actin cytoskeleton|response to estradiol|protein complex binding|Arp2/3 complex-mediated actin nucleation|tubulobulbar complex|Fc-gamma receptor signaling pathway involved in phagocytosis|response to estrogen|ephrin receptor signaling pathway|extracellular exosome hsa04144,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132 Endocytosis|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection ARPC2 7198.65089881808 7183.77542790631 7213.52636972985 1.00414140755402 0.00596245017674776 0.963776110291192 1 54.8018 56.6633 56.8159 56.4617 GeneID:10109,Genbank:NM_152862.2,HGNC:HGNC:705,MIM:604224 actin related protein 2/3 complex subunit 2 GO:0003779,GO:0005200,GO:0005768,GO:0005829,GO:0005885,GO:0005925,GO:0006928,GO:0010592,GO:0015629,GO:0030041,GO:0031252,GO:0034314,GO:0036195,GO:0038096,GO:0043005,GO:0045202,GO:0048013,GO:0061024,GO:0070062,GO:1900026 actin binding|structural constituent of cytoskeleton|endosome|cytosol|Arp2/3 protein complex|focal adhesion|movement of cell or subcellular component|positive regulation of lamellipodium assembly|actin cytoskeleton|actin filament polymerization|cell leading edge|Arp2/3 complex-mediated actin nucleation|muscle cell projection membrane|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron projection|synapse|ephrin receptor signaling pathway|membrane organization|extracellular exosome|positive regulation of substrate adhesion-dependent cell spreading hsa04144,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132 Endocytosis|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection ARPC3 4465.44896276547 4608.44896638501 4322.44895914593 0.937940072825972 -0.092432346345734 0.597327330511294 1 175.193 176.053 150.024 178.671 GeneID:10094,Genbank:NM_001287222.1,HGNC:HGNC:706,MIM:604225 actin related protein 2/3 complex subunit 3 GO:0003779,GO:0005200,GO:0005829,GO:0005885,GO:0005925,GO:0006928,GO:0015629,GO:0016020,GO:0030027,GO:0031941,GO:0034314,GO:0038096,GO:0048013,GO:0061024,GO:0061850,GO:0070062,GO:1990090 actin binding|structural constituent of cytoskeleton|cytosol|Arp2/3 protein complex|focal adhesion|movement of cell or subcellular component|actin cytoskeleton|membrane|lamellipodium|filamentous actin|Arp2/3 complex-mediated actin nucleation|Fc-gamma receptor signaling pathway involved in phagocytosis|ephrin receptor signaling pathway|membrane organization|growth cone leading edge|extracellular exosome|cellular response to nerve growth factor stimulus hsa04144,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132 Endocytosis|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection ARPC4 3680.25994471699 3518.10373967082 3842.41614976316 1.0921838678136 0.127215752643359 0.361208501482558 1 112.709 121.736 125.593 131.933 GeneID:10093,Genbank:NM_001024959.2,HGNC:HGNC:707,MIM:604226 actin related protein 2/3 complex subunit 4 GO:0003779,GO:0005200,GO:0005829,GO:0005885,GO:0019899,GO:0030041,GO:0034314,GO:0038096,GO:0042995,GO:0045010,GO:0048013,GO:0061024,GO:0070062 actin binding|structural constituent of cytoskeleton|cytosol|Arp2/3 protein complex|enzyme binding|actin filament polymerization|Arp2/3 complex-mediated actin nucleation|Fc-gamma receptor signaling pathway involved in phagocytosis|cell projection|actin nucleation|ephrin receptor signaling pathway|membrane organization|extracellular exosome hsa04144,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132 Endocytosis|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection ARPC4-TTLL3 3.73082568449026 4.55472144167109 2.90692992730943 0.638223426950761 -0.647866529006934 0.741979207665512 1 4.00454 4.52948 4.89861 4.58481 GeneID:100526693,Genbank:NM_001198793.1,HGNC:HGNC:38830 ARPC4-TTLL3 readthrough GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0005930,GO:0015630,GO:0018094,GO:0035082,GO:0060271,GO:0070735,GO:0070736 ATP binding|cytosol|microtubule|cilium|axoneme|microtubule cytoskeleton|protein polyglycylation|axoneme assembly|cilium assembly|protein-glycine ligase activity|protein-glycine ligase activity, initiating ARPC5 6545.7743832523 7147.50542051063 5944.04334599396 0.831624881169982 -0.265995172425135 0.0416790120912604 0.762892637318431 117.414 124.376 97.4745 107.999 GeneID:10092,Genbank:NM_005717.3,HGNC:HGNC:708,MIM:604227 actin related protein 2/3 complex subunit 5 GO:0003779,GO:0005200,GO:0005576,GO:0005737,GO:0005768,GO:0005829,GO:0005885,GO:0005925,GO:0006928,GO:0014909,GO:0015629,GO:0016477,GO:0021769,GO:0030011,GO:0030027,GO:0030036,GO:0030426,GO:0034314,GO:0034774,GO:0038096,GO:0043312,GO:0048013,GO:0051639,GO:0061024,GO:0061842,GO:0070062,GO:0097581,GO:1904813 actin binding|structural constituent of cytoskeleton|extracellular region|cytoplasm|endosome|cytosol|Arp2/3 protein complex|focal adhesion|movement of cell or subcellular component|smooth muscle cell migration|actin cytoskeleton|cell migration|orbitofrontal cortex development|maintenance of cell polarity|lamellipodium|actin cytoskeleton organization|growth cone|Arp2/3 complex-mediated actin nucleation|secretory granule lumen|Fc-gamma receptor signaling pathway involved in phagocytosis|neutrophil degranulation|ephrin receptor signaling pathway|actin filament network formation|membrane organization|microtubule organizing center localization|extracellular exosome|lamellipodium organization|ficolin-1-rich granule lumen hsa04144,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132 Endocytosis|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection ARPC5L 1112.35344444248 1187.13349227663 1037.57339660834 0.87401577274897 -0.194268779622136 0.191018547776337 1 13.6587 14.3946 12.9907 12.8404 GeneID:81873,Genbank:NM_030978.2,HGNC:HGNC:23366 actin related protein 2/3 complex subunit 5 like GO:0005737,GO:0005885,GO:0005925,GO:0016477,GO:0034314,GO:0051015,GO:0070062 cytoplasm|Arp2/3 protein complex|focal adhesion|cell migration|Arp2/3 complex-mediated actin nucleation|actin filament binding|extracellular exosome hsa04144,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132 Endocytosis|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection ARPIN 789.309715143808 725.195384335559 853.424045952056 1.17681946739634 0.23489301751423 0.1327708092383 1 5.17004 4.9073 6.02575 5.86342 GeneID:348110,Genbank:NM_182616.3,HGNC:HGNC:28782,MIM:615543 actin related protein 2/3 complex inhibitor GO:0030027,GO:0030336,GO:0033058,GO:0051126,GO:2000393 lamellipodium|negative regulation of cell migration|directional locomotion|negative regulation of actin nucleation|negative regulation of lamellipodium morphogenesis ARPP19 4720.44116309195 5184.61156724828 4256.27075893562 0.820943035698743 -0.284645976375301 0.0570810574925545 0.86572937197041 45.0526 40.1919 38.1341 31.66 GeneID:10776,Genbank:NM_001306191.1,HGNC:HGNC:16967,MIM:605487 cAMP regulated phosphoprotein 19 GO:0000086,GO:0000278,GO:0004864,GO:0005102,GO:0005654,GO:0005737,GO:0015459,GO:0019212,GO:0019888,GO:0035308,GO:0045722,GO:0046326,GO:0051301,GO:0051721 G2/M transition of mitotic cell cycle|mitotic cell cycle|protein phosphatase inhibitor activity|receptor binding|nucleoplasm|cytoplasm|potassium channel regulator activity|phosphatase inhibitor activity|protein phosphatase regulator activity|negative regulation of protein dephosphorylation|positive regulation of gluconeogenesis|positive regulation of glucose import|cell division|protein phosphatase 2A binding ARPP21 4.4749366266582 3.13253351048394 5.81733974283245 1.85707183127108 0.893029619589079 0.571407772448678 1 0.00675976 0 0.00978588 0.00606652 GeneID:10777,Genbank:NM_001267616.1,HGNC:HGNC:16968,MIM:605488 cAMP regulated phosphoprotein 21 GO:0005516,GO:0005737 calmodulin binding|cytoplasm ARR3 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0 0 0 GeneID:407,Genbank:NM_004312.2,HGNC:HGNC:710,MIM:301770 arrestin 3 GO:0001750,GO:0001917,GO:0001932,GO:0002046,GO:0005737,GO:0006897,GO:0007165,GO:0007601,GO:0045202,GO:0051219 photoreceptor outer segment|photoreceptor inner segment|regulation of protein phosphorylation|opsin binding|cytoplasm|endocytosis|signal transduction|visual perception|synapse|phosphoprotein binding ARRB1 136.704589447844 128.002654458532 145.406524437156 1.13596491457341 0.183918276433592 0.513138550314522 1 0.412016 0.54461 0.612219 0.446224 GeneID:408,Genbank:NM_020251.3,HGNC:HGNC:711,MIM:107940 arrestin beta 1 GO:0001934,GO:0002092,GO:0005634,GO:0005886,GO:0005905,GO:0006351,GO:0006355,GO:0006511,GO:0007165,GO:0015031,GO:0031143,GO:0031410,GO:0045746 positive regulation of protein phosphorylation|positive regulation of receptor internalization|nucleus|plasma membrane|clathrin-coated pit|transcription, DNA-templated|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|signal transduction|protein transport|pseudopodium|cytoplasmic vesicle|negative regulation of Notch signaling pathway hsa04010,hsa04062,hsa04144,hsa04340,hsa04740,hsa04926,hsa04928,hsa05032 MAPK signaling pathway|Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Olfactory transduction|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction ARRB2 1726.1056679563 1722.63811143939 1729.57322447322 1.00402586764323 0.00579643924870325 0.991173064996082 1 16.2495 16.2903 16.4403 16.9309 GeneID:409,Genbank:NM_001257328.1,HGNC:HGNC:712,MIM:107941 arrestin beta 2 hsa04010,hsa04062,hsa04144,hsa04340,hsa04728,hsa04740,hsa04926,hsa04928,hsa05032 MAPK signaling pathway|Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Dopaminergic synapse|Olfactory transduction|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction ARRDC1 517.540175462013 531.054741924709 504.025608999317 0.949102925194812 -0.0753635465067446 0.662729967162842 1 3.55372 3.47305 3.78448 3.35619 GeneID:92714,Genbank:NM_001317968.1,HGNC:HGNC:28633 arrestin domain containing 1 GO:0005886,GO:0006511,GO:0006858,GO:0015031,GO:0016567,GO:0031410,GO:0031625,GO:0042802,GO:0045746,GO:0070062,GO:0140112,GO:1903561,GO:1990756,GO:1990763 plasma membrane|ubiquitin-dependent protein catabolic process|extracellular transport|protein transport|protein ubiquitination|cytoplasmic vesicle|ubiquitin protein ligase binding|identical protein binding|negative regulation of Notch signaling pathway|extracellular exosome|extracellular vesicle biogenesis|extracellular vesicle|protein binding, bridging involved in substrate recognition for ubiquitination|arrestin family protein binding ARRDC2 363.064390882136 375.292539344841 350.836242419432 0.934834044481398 -0.0972178202123558 0.6839693478645 1 4.99974 6.11342 4.71108 5.76968 GeneID:27106,Genbank:NM_001025604.2,HGNC:HGNC:25225 arrestin domain containing 2 GO:0005886,GO:0031410 plasma membrane|cytoplasmic vesicle ARRDC3 370.530331150822 364.922570662873 376.13809163877 1.0307339744854 0.0436720308498661 0.879133429404405 1 3.25203 2.78358 3.934 2.40698 GeneID:57561,Genbank:NM_001329672.1,HGNC:HGNC:29263,MIM:612464 arrestin domain containing 3 GO:0001659,GO:0005764,GO:0005768,GO:0005769,GO:0005886,GO:0031651,GO:0031699,GO:0043588,GO:0044252,GO:0051443,GO:0060613,GO:0071879,GO:0090327 temperature homeostasis|lysosome|endosome|early endosome|plasma membrane|negative regulation of heat generation|beta-3 adrenergic receptor binding|skin development|negative regulation of multicellular organismal metabolic process|positive regulation of ubiquitin-protein transferase activity|fat pad development|positive regulation of adrenergic receptor signaling pathway|negative regulation of locomotion involved in locomotory behavior ARRDC4 56.978302674266 54.3488823417275 59.6077230068045 1.09676078768301 0.133248896701567 0.747291290017241 1 0.550284 0.579017 0.626026 0.611681 GeneID:91947,Genbank:NM_183376.2,HGNC:HGNC:28087 arrestin domain containing 4 GO:0005768,GO:0005769,GO:0005886,GO:0015031,GO:0016567,GO:0051443,GO:0140112,GO:1903561,GO:1990756 endosome|early endosome|plasma membrane|protein transport|protein ubiquitination|positive regulation of ubiquitin-protein transferase activity|extracellular vesicle biogenesis|extracellular vesicle|protein binding, bridging involved in substrate recognition for ubiquitination ARSA 310.95504368868 271.033826243471 350.876261133888 1.29458476086558 0.372489426479564 0.0650206854117648 0.901277047586747 2.06079 2.31188 2.87074 2.79974 GeneID:410,Genbank:NM_001085427.2,HGNC:HGNC:713,MIM:607574 arylsulfatase A hsa00600,hsa04142 Sphingolipid metabolism|Lysosome ARSB 1308.24369592593 1327.31927119834 1289.16812065352 0.97125699040716 -0.0420750178514922 0.778483549566609 1 3.68995 3.64789 3.78027 3.22407 GeneID:411,Genbank:XM_011543390.1,HGNC:HGNC:714,MIM:611542 arylsulfatase B GO:0003943,GO:0004065,GO:0005576,GO:0005739,GO:0005764,GO:0005788,GO:0005791,GO:0005794,GO:0006687,GO:0006914,GO:0007040,GO:0007041,GO:0007417,GO:0007584,GO:0009268,GO:0009986,GO:0010632,GO:0010976,GO:0030207,GO:0035578,GO:0043202,GO:0043312,GO:0043627,GO:0043687,GO:0046872,GO:0051597,GO:0061580,GO:0070062,GO:1904813 N-acetylgalactosamine-4-sulfatase activity|arylsulfatase activity|extracellular region|mitochondrion|lysosome|endoplasmic reticulum lumen|rough endoplasmic reticulum|Golgi apparatus|glycosphingolipid metabolic process|autophagy|lysosome organization|lysosomal transport|central nervous system development|response to nutrient|response to pH|cell surface|regulation of epithelial cell migration|positive regulation of neuron projection development|chondroitin sulfate catabolic process|azurophil granule lumen|lysosomal lumen|neutrophil degranulation|response to estrogen|post-translational protein modification|metal ion binding|response to methylmercury|colon epithelial cell migration|extracellular exosome|ficolin-1-rich granule lumen hsa00531,hsa04142 Glycosaminoglycan degradation|Lysosome ARSD 353.104475426254 354.86241094094 351.346539911568 0.990092297969656 -0.0143650731129706 0.9643493947097 1 1.96045 1.70691 1.79318 1.72198 GeneID:414,Genbank:NM_001669.3,HGNC:HGNC:717,MIM:300002 arylsulfatase D GO:0004065,GO:0005764,GO:0005788,GO:0006687,GO:0043687,GO:0046872,GO:0070062 arylsulfatase activity|lysosome|endoplasmic reticulum lumen|glycosphingolipid metabolic process|post-translational protein modification|metal ion binding|extracellular exosome ARSE 93.570561226021 98.4641001721433 88.6770222798988 0.900602576216775 -0.151037490303486 0.633113087896271 1 1.03504 0.87 0.776885 1.03197 GeneID:415,Genbank:NM_001282631.1,HGNC:HGNC:719,MIM:300180 arylsulfatase E (chondrodysplasia punctata 1) GO:0001501,GO:0004065,GO:0005788,GO:0005794,GO:0005795,GO:0006687,GO:0043687,GO:0046872,GO:0070062 skeletal system development|arylsulfatase activity|endoplasmic reticulum lumen|Golgi apparatus|Golgi stack|glycosphingolipid metabolic process|post-translational protein modification|metal ion binding|extracellular exosome ARSF 37.7194623423471 26.4922646701666 48.9466600145275 1.8475830822288 0.885639241028771 0.0600936977625345 0.879410748501007 0.290886 0.442225 0.46024 0.716224 GeneID:416,Genbank:NM_001201538.1,HGNC:HGNC:721,MIM:300003 arylsulfatase F GO:0004065,GO:0005788,GO:0006687,GO:0043687,GO:0046872,GO:0070062 arylsulfatase activity|endoplasmic reticulum lumen|glycosphingolipid metabolic process|post-translational protein modification|metal ion binding|extracellular exosome ARSG 66.9439246435043 58.3076711769634 75.5801781100452 1.29623043734091 0.374322216105637 0.514240877526475 1 0.157301 0.102998 0.133056 0.203653 GeneID:22901,Genbank:NM_001352904.1,HGNC:HGNC:24102,MIM:610008 arylsulfatase G GO:0004065,GO:0005615,GO:0005764,GO:0005783,GO:0005788,GO:0006687,GO:0006790,GO:0043687,GO:0046872 arylsulfatase activity|extracellular space|lysosome|endoplasmic reticulum|endoplasmic reticulum lumen|glycosphingolipid metabolic process|sulfur compound metabolic process|post-translational protein modification|metal ion binding hsa04142 Lysosome ARSJ 1479.69645619457 1509.24736318069 1450.14554920846 0.960840207235696 -0.0576315716895099 0.697723053779102 1 8.79387 8.58188 9.57515 7.27733 GeneID:79642,Genbank:XM_024454216.1,HGNC:HGNC:26286,MIM:610010 arylsulfatase family member J GO:0004065,GO:0005576,GO:0005788,GO:0006687,GO:0043687,GO:0046872 arylsulfatase activity|extracellular region|endoplasmic reticulum lumen|glycosphingolipid metabolic process|post-translational protein modification|metal ion binding ARSK 279.494880065562 296.794871137401 262.194888993722 0.883421226212293 -0.17882659805003 0.395263460065592 1 3.25481 3.17464 3.08911 2.7834 GeneID:153642,Genbank:XM_005271904.4,HGNC:HGNC:25239,MIM:610011 arylsulfatase family member K GO:0004065,GO:0005576,GO:0005788,GO:0006687,GO:0043687,GO:0046872 arylsulfatase activity|extracellular region|endoplasmic reticulum lumen|glycosphingolipid metabolic process|post-translational protein modification|metal ion binding ARTN 10.3232637095814 9.98372448277907 10.6628029363838 1.06801854906714 0.0949367035936188 0.94400606612989 1 0.278414 0.0877474 0.190142 0.208561 GeneID:9048,Genbank:NM_057090.2,HGNC:HGNC:727,MIM:603886 artemin GO:0000165,GO:0005088,GO:0005102,GO:0005576,GO:0005615,GO:0005622,GO:0007165,GO:0007405,GO:0007411,GO:0007422,GO:0008083,GO:0050930,GO:0061146,GO:0097021 MAPK cascade|Ras guanyl-nucleotide exchange factor activity|receptor binding|extracellular region|extracellular space|intracellular|signal transduction|neuroblast proliferation|axon guidance|peripheral nervous system development|growth factor activity|induction of positive chemotaxis|Peyer's patch morphogenesis|lymphocyte migration into lymphoid organs ARV1 429.812346825084 428.266243029212 431.358450620956 1.00722029261487 0.0103792546508321 0.955001993465283 1 9.10942 9.24901 10.504 8.08904 GeneID:64801,Genbank:NM_001346992.1,HGNC:HGNC:29561,MIM:611647 ARV1 homolog, fatty acid homeostasis modulator GO:0005789,GO:0005794,GO:0006665,GO:0006695,GO:0008206,GO:0015248,GO:0016021,GO:0030301,GO:0032383,GO:0032541,GO:0090181,GO:0097036 endoplasmic reticulum membrane|Golgi apparatus|sphingolipid metabolic process|cholesterol biosynthetic process|bile acid metabolic process|sterol transporter activity|integral component of membrane|cholesterol transport|regulation of intracellular cholesterol transport|cortical endoplasmic reticulum|regulation of cholesterol metabolic process|regulation of plasma membrane sterol distribution ARVCF 148.556912795797 160.462019846449 136.651805745145 0.851614642990981 -0.231727338628329 0.354491625017522 1 0.384905 0.547285 0.40515 0.499034 GeneID:421,Genbank:XM_006724243.3,HGNC:HGNC:728,MIM:602269 ARVCF, delta catenin family member GO:0005622,GO:0005634,GO:0005737,GO:0005886,GO:0007155,GO:0007275,GO:0016339 intracellular|nucleus|cytoplasm|plasma membrane|cell adhesion|multicellular organism development|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ARX 6.44618427090284 5.14084539299833 7.75152314880735 1.50783043570318 0.592474198285205 0.655307116591104 1 0.117645 0.0796193 0.107497 0.201151 GeneID:170302,Genbank:NM_139058.2,HGNC:HGNC:18060,MIM:300382 aristaless related homeobox GO:0000980,GO:0000981,GO:0001206,GO:0003682,GO:0005634,GO:0006351,GO:0007411,GO:0010628,GO:0021759,GO:0021800,GO:0021831,GO:0021846,GO:0021853,GO:0042127,GO:0044241,GO:0046622,GO:0072148 RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding|chromatin binding|nucleus|transcription, DNA-templated|axon guidance|positive regulation of gene expression|globus pallidus development|cerebral cortex tangential migration|embryonic olfactory bulb interneuron precursor migration|cell proliferation in forebrain|cerebral cortex GABAergic interneuron migration|regulation of cell proliferation|lipid digestion|positive regulation of organ growth|epithelial cell fate commitment AS3MT 2.42860466819925 0.980142803914724 3.87706653248377 3.95561393400904 1.98390162663545 0.424234826993998 1 0 0.0299637 0.0306283 0.0284097 GeneID:57412,Genbank:NM_020682.3,HGNC:HGNC:17452,MIM:611806 arsenite methyltransferase GO:0005739,GO:0005829,GO:0009404,GO:0018872,GO:0030791,GO:0030792,GO:0032259 mitochondrion|cytosol|toxin metabolic process|arsonoacetate metabolic process|arsenite methyltransferase activity|methylarsonite methyltransferase activity|methylation ASAH1 2806.25580275471 2932.99096270162 2679.52064280781 0.913579576917502 -0.130397695291219 0.356615688488656 1 32.1588 28.618 28.1449 26.3889 GeneID:427,Genbank:NM_004315.5,HGNC:HGNC:735,MIM:613468 N-acylsphingosine amidohydrolase 1 GO:0003824,GO:0005576,GO:0005615,GO:0006672,GO:0006687,GO:0017040,GO:0043202,GO:0043312,GO:0070062,GO:1904724,GO:1904813 catalytic activity|extracellular region|extracellular space|ceramide metabolic process|glycosphingolipid metabolic process|ceramidase activity|lysosomal lumen|neutrophil degranulation|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen hsa00600,hsa04071,hsa04142 Sphingolipid metabolism|Sphingolipid signaling pathway|Lysosome ASAH2 2.7776325536298 3.13253351048394 2.42273159677566 0.773409634299929 -0.370695358821752 0.960660496689595 1 0.0153759 0.00735411 0.022214 0.0137814 GeneID:56624,Genbank:XM_011539971.2,HGNC:HGNC:18860,MIM:611202 N-acylsphingosine amidohydrolase 2 GO:0005739,GO:0005886,GO:0006672,GO:0006915,GO:0007165,GO:0016021,GO:0017040 mitochondrion|plasma membrane|ceramide metabolic process|apoptotic process|signal transduction|integral component of membrane|ceramidase activity hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway ASAH2B 124.145174109031 139.705516174861 108.584832043201 0.777240834981003 -0.363566395100262 0.543246853861305 1 2.01777 1.18692 1.62739 0.890102 GeneID:653308,Genbank:NM_001321960.1,HGNC:HGNC:23456 N-acylsphingosine amidohydrolase 2B GO:0005739,GO:0005886,GO:0006672,GO:0006915,GO:0007165,GO:0016021,GO:0017040 mitochondrion|plasma membrane|ceramide metabolic process|apoptotic process|signal transduction|integral component of membrane|ceramidase activity ASAP1 2396.01781534113 2623.47385242355 2168.56177825872 0.826599348895899 -0.274739867571023 0.237408432972014 1 11.5594 10.3798 10.9698 7.46053 GeneID:50807,Genbank:XM_017013468.1,HGNC:HGNC:2720,MIM:605953 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 hsa04144,hsa04666 Endocytosis|Fc gamma R-mediated phagocytosis ASAP2 881.350576869322 899.485264641292 863.215889097352 0.959677632341867 -0.0593782268929103 0.707262163713065 1 4.14387 4.202 4.64838 3.58315 GeneID:8853,Genbank:NM_003887.2,HGNC:HGNC:2721,MIM:603817 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 GO:0005096,GO:0005886,GO:0032580,GO:0046872 GTPase activator activity|plasma membrane|Golgi cisterna membrane|metal ion binding hsa04144,hsa04666 Endocytosis|Fc gamma R-mediated phagocytosis ASAP3 463.2038543691 362.799605921627 563.608102816573 1.55349700941606 0.635519464179566 0.000339913288134576 0.0488987647139116 2.68826 2.43146 3.89409 3.8554 GeneID:55616,Genbank:XM_017001687.1,HGNC:HGNC:14987,MIM:616594 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 GO:0001726,GO:0005096,GO:0005654,GO:0005829,GO:0005925,GO:0016477,GO:0043231,GO:0043547,GO:0046872,GO:0051492 ruffle|GTPase activator activity|nucleoplasm|cytosol|focal adhesion|cell migration|intracellular membrane-bounded organelle|positive regulation of GTPase activity|metal ion binding|regulation of stress fiber assembly hsa04144,hsa04666 Endocytosis|Fc gamma R-mediated phagocytosis ASB1 2045.36412597209 2103.82909091622 1986.89916102795 0.944420423506291 -0.0824988540698059 0.54798662824148 1 13.739 14.562 13.323 13.7919 GeneID:51665,Genbank:NM_001040445.2,HGNC:HGNC:16011,MIM:605758 ankyrin repeat and SOCS box containing 1 GO:0000151,GO:0005829,GO:0016567,GO:0030539,GO:0035556,GO:0042036,GO:0043687 ubiquitin ligase complex|cytosol|protein ubiquitination|male genitalia development|intracellular signal transduction|negative regulation of cytokine biosynthetic process|post-translational protein modification ASB12 7.73426596113667 5.77499561901052 9.69353630326283 1.67853569816624 0.747203219799688 0.489322022462789 1 0.285342 0.10885 0.382276 0.142734 GeneID:142689,Genbank:NM_130388.3,HGNC:HGNC:19763,MIM:300891 ankyrin repeat and SOCS box containing 12 GO:0000151,GO:0005829,GO:0016567,GO:0043687 ubiquitin ligase complex|cytosol|protein ubiquitination|post-translational protein modification ASB13 510.283694719021 531.092959544286 489.474429893756 0.921636073492215 -0.117730908890761 0.502276620720786 1 9.69456 9.19363 9.14266 8.61138 GeneID:79754,Genbank:NM_024701.3,HGNC:HGNC:19765,MIM:615055 ankyrin repeat and SOCS box containing 13 GO:0005829,GO:0016567,GO:0035556,GO:0043687 cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB14 12.8890228324568 19.4773775636008 6.30066810131283 0.323486469404766 -1.62822272557803 0.235663291804233 1 0.0113419 0.0107866 0.0108398 0 GeneID:142686,Genbank:NM_001142733.2,HGNC:HGNC:19766 ankyrin repeat and SOCS box containing 14 GO:0000151,GO:0004842,GO:0005634,GO:0005737,GO:0005829,GO:0031625,GO:0035556,GO:0043687 ubiquitin ligase complex|ubiquitin-protein transferase activity|nucleus|cytoplasm|cytosol|ubiquitin protein ligase binding|intracellular signal transduction|post-translational protein modification ASB16 11.7441466826885 12.8281003451534 10.6601930202236 0.831003245484523 -0.267073983432917 0.794796046200801 1 0.161248 0.190174 0.118262 0.248899 GeneID:92591,Genbank:NM_080863.4,HGNC:HGNC:19768,MIM:615056 ankyrin repeat and SOCS box containing 16 GO:0000151,GO:0004842,GO:0005634,GO:0005737,GO:0005829,GO:0031625,GO:0035556,GO:0043687 ubiquitin ligase complex|ubiquitin-protein transferase activity|nucleus|cytoplasm|cytosol|ubiquitin protein ligase binding|intracellular signal transduction|post-translational protein modification ASB2 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0.011126 GeneID:51676,Genbank:NM_001202429.1,HGNC:HGNC:16012,MIM:605759 ankyrin repeat and SOCS box containing 2 GO:0000151,GO:0000209,GO:0016567,GO:0031466,GO:0035556,GO:0035914,GO:0042787,GO:0045445,GO:0061630 ubiquitin ligase complex|protein polyubiquitination|protein ubiquitination|Cul5-RING ubiquitin ligase complex|intracellular signal transduction|skeletal muscle cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|myoblast differentiation|ubiquitin protein ligase activity ASB3 5.72108336670718 5.6309167949557 5.81124993845867 1.03202553865909 0.0454786723512228 1 1 1.6518 1.74612 1.22156 2.19904 GeneID:51130,Genbank:NM_145863.2,HGNC:HGNC:16013,MIM:605760 ankyrin repeat and SOCS box containing 3 GO:0000151,GO:0004842,GO:0005634,GO:0005737,GO:0005829,GO:0031625,GO:0035556,GO:0043687 ubiquitin ligase complex|ubiquitin-protein transferase activity|nucleus|cytoplasm|cytosol|ubiquitin protein ligase binding|intracellular signal transduction|post-translational protein modification ASB6 950.29416296561 972.07265005992 928.5156758713 0.955191647264292 -0.06613787397044 0.662735044243199 1 8.77662 8.83395 8.46508 8.6785 GeneID:140459,Genbank:NM_177999.2,HGNC:HGNC:17181,MIM:615051 ankyrin repeat and SOCS box containing 6 GO:0005829,GO:0016567,GO:0035556,GO:0043687 cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB7 426.914276338279 444.764974561491 409.063578115067 0.91972974832017 -0.12071809027756 0.514770153674663 1 3.86171 3.62909 3.91505 3.0726 GeneID:140460,Genbank:NM_198243.2,HGNC:HGNC:17182,MIM:615052 ankyrin repeat and SOCS box containing 7 GO:0005829,GO:0016567,GO:0035556,GO:0043687 cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB8 441.383935870303 417.542507115942 465.225364624664 1.11419881017163 0.156006680485696 0.382161120243125 1 5.33797 5.04789 5.97298 5.83761 GeneID:140461,Genbank:NM_001319297.1,HGNC:HGNC:17183,MIM:615053 ankyrin repeat and SOCS box containing 8 GO:0005829,GO:0016567,GO:0035556,GO:0043687 cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification ASB9 89.7410955768544 97.099747170749 82.3824439829598 0.848431086417671 -0.237130612869689 0.443507810534175 1 1.55407 1.75915 1.5839 1.58727 GeneID:140462,Genbank:XM_017029284.1,HGNC:HGNC:17184,MIM:300890 ankyrin repeat and SOCS box containing 9 GO:0005739,GO:0005829,GO:0016567,GO:0035556,GO:0043687,GO:0045732 mitochondrion|cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification|positive regulation of protein catabolic process ASCC1 862.552521352455 810.620678754448 914.484363950462 1.12812859074309 0.17393152399006 0.265829014985859 1 3.99412 4.33389 4.8405 4.75079 GeneID:51008,Genbank:NM_001198800.2,HGNC:HGNC:24268,MIM:614215 activating signal cointegrator 1 complex subunit 1 GO:0003723,GO:0005634,GO:0005667,GO:0006351,GO:0006355,GO:0031594 RNA binding|nucleus|transcription factor complex|transcription, DNA-templated|regulation of transcription, DNA-templated|neuromuscular junction ASCC2 1441.24543437713 1337.97536352671 1544.51550522755 1.15436767173084 0.207102802579774 0.151872340469404 1 7.86566 7.69132 9.48742 9.06025 GeneID:84164,Genbank:NM_001242906.1,HGNC:HGNC:24103,MIM:614216 activating signal cointegrator 1 complex subunit 2 GO:0005634,GO:0005654,GO:0006307,GO:0006351,GO:0006355,GO:0099053 nucleus|nucleoplasm|DNA dealkylation involved in DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|activating signal cointegrator 1 complex ASCC3 712.945273318255 733.708894612466 692.181652024042 0.943400927952007 -0.0840570749493617 0.793203867145538 1 1.5911 1.46556 1.79737 1.12417 GeneID:10973,Genbank:NM_006828.3,HGNC:HGNC:18697,MIM:614217 activating signal cointegrator 1 complex subunit 3 GO:0003723,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005829,GO:0006307,GO:0006351,GO:0006355,GO:0008283,GO:0016020,GO:0032508,GO:0043140,GO:0099053 RNA binding|ATP binding|intracellular|nucleus|nucleoplasm|cytosol|DNA dealkylation involved in DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|cell proliferation|membrane|DNA duplex unwinding|ATP-dependent 3'-5' DNA helicase activity|activating signal cointegrator 1 complex ASCL1 1.48335117242078 1.02816907859967 1.93853326624189 1.88542264749112 0.914887962799843 0.868258168018795 1 0.0244424 0.0219919 0.0456114 0.0426246 GeneID:429,Genbank:NM_004316.3,HGNC:HGNC:738,MIM:100790 achaete-scute family bHLH transcription factor 1 ASCL5 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0515747 0 GeneID:647219,Genbank:NM_001270601.1,HGNC:HGNC:33169 achaete-scute family bHLH transcription factor 5 GO:0000977,GO:0006351,GO:0006357,GO:0046983,GO:0090575 RNA polymerase II regulatory region sequence-specific DNA binding|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|protein dimerization activity|RNA polymerase II transcription factor complex ASF1A 951.382952746791 979.95099310996 922.814912383623 0.941694961147995 -0.0866682848450396 0.586395517909076 1 16.5878 16.7197 17.7197 13.7427 GeneID:25842,Genbank:NM_014034.2,HGNC:HGNC:20995,MIM:609189 anti-silencing function 1A histone chaperone GO:0000790,GO:0001649,GO:0003682,GO:0005634,GO:0005654,GO:0006281,GO:0006334,GO:0006335,GO:0006336,GO:0006351,GO:0016569,GO:0031936,GO:0042393,GO:0042692,GO:0043234 nuclear chromatin|osteoblast differentiation|chromatin binding|nucleus|nucleoplasm|DNA repair|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|transcription, DNA-templated|covalent chromatin modification|negative regulation of chromatin silencing|histone binding|muscle cell differentiation|protein complex ASF1B 2933.18120599041 2918.83302032467 2947.52939165615 1.00983145357465 0.014114519330192 0.938445377534896 1 67.4229 72.4671 73.717 69.8124 GeneID:55723,Genbank:NM_018154.2,HGNC:HGNC:20996,MIM:609190 anti-silencing function 1B histone chaperone GO:0000790,GO:0005654,GO:0006335,GO:0006336,GO:0006351,GO:0006355,GO:0007275,GO:0007283,GO:0016569,GO:0030154,GO:0042393,GO:0043234 nuclear chromatin|nucleoplasm|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|spermatogenesis|covalent chromatin modification|cell differentiation|histone binding|protein complex ASGR1 18.3301778785131 16.3066264335398 20.3537293234864 1.24818762522347 0.319834813714526 0.669468489982868 1 0.202944 0.275293 0.374324 0.325775 GeneID:432,Genbank:NM_001197216.2,HGNC:HGNC:742,MIM:108360 asialoglycoprotein receptor 1 hsa04918 Thyroid hormone synthesis ASGR2 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0 0 0 GeneID:433,Genbank:XM_017024652.2,HGNC:HGNC:743,MIM:108361 asialoglycoprotein receptor 2 hsa04918 Thyroid hormone synthesis ASH1L 546.6114433408 537.722619452518 555.500267229082 1.03306100047393 0.0469254453771346 0.883675665893114 1 1.43372 1.26651 1.78447 1.04165 GeneID:55870,Genbank:NM_018489.2,HGNC:HGNC:19088,MIM:607999 ASH1 like histone lysine methyltransferase GO:0001501,GO:0002674,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005694,GO:0005794,GO:0005923,GO:0006323,GO:0006366,GO:0007267,GO:0007338,GO:0009791,GO:0018024,GO:0032635,GO:0042800,GO:0043124,GO:0043409,GO:0045944,GO:0046697,GO:0046872,GO:0046975,GO:0061038,GO:0070062,GO:0097676,GO:0097722,GO:1903699,GO:1903709 skeletal system development|negative regulation of acute inflammatory response|DNA binding|chromatin binding|nucleus|nucleoplasm|chromosome|Golgi apparatus|bicellular tight junction|DNA packaging|transcription from RNA polymerase II promoter|cell-cell signaling|single fertilization|post-embryonic development|histone-lysine N-methyltransferase activity|interleukin-6 production|histone methyltransferase activity (H3-K4 specific)|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of MAPK cascade|positive regulation of transcription from RNA polymerase II promoter|decidualization|metal ion binding|histone methyltransferase activity (H3-K36 specific)|uterus morphogenesis|extracellular exosome|histone H3-K36 dimethylation|sperm motility|tarsal gland development|uterine gland development hsa00310 Lysine degradation ASH2L 1728.2093888 1738.44282381415 1717.97595378585 0.988226894926926 -0.0170857751374553 0.911818367543891 1 15.0801 14.9449 15.1 15.1104 GeneID:9070,Genbank:XM_005273682.1,HGNC:HGNC:744,MIM:604782 ASH2 like histone lysine methyltransferase complex subunit hsa04934 Cushing syndrome ASIC1 202.153574975925 197.860316873516 206.446833078334 1.04339685865512 0.061287994976759 0.800887701526764 1 1.43917 1.33898 1.48938 1.49827 GeneID:41,Genbank:NM_020039.3,HGNC:HGNC:100,MIM:602866 acid sensing ion channel subunit 1 GO:0005794,GO:0005886,GO:0005887,GO:0006810,GO:0006814,GO:0007165,GO:0007613,GO:0008306,GO:0009268,GO:0009986,GO:0010447,GO:0015280,GO:0034220,GO:0035725,GO:0042391,GO:0044736,GO:0045202,GO:0046929,GO:0050915,GO:0070207,GO:0070588,GO:0071467 Golgi apparatus|plasma membrane|integral component of plasma membrane|transport|sodium ion transport|signal transduction|memory|associative learning|response to pH|cell surface|response to acidic pH|ligand-gated sodium channel activity|ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|acid-sensing ion channel activity|synapse|negative regulation of neurotransmitter secretion|sensory perception of sour taste|protein homotrimerization|calcium ion transmembrane transport|cellular response to pH hsa04750 Inflammatory mediator regulation of TRP channels ASIC2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0104461 GeneID:40,Genbank:NM_001094.4,HGNC:HGNC:99,MIM:601784 acid sensing ion channel subunit 2 GO:0003026,GO:0005886,GO:0005887,GO:0007268,GO:0007417,GO:0007422,GO:0007602,GO:0007605,GO:0010447,GO:0015280,GO:0015672,GO:0019229,GO:0034220,GO:0034765,GO:0035418,GO:0042391,GO:0043025,GO:0043066,GO:0043197,GO:0044736,GO:0050915,GO:0050974,GO:0051965 regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback|plasma membrane|integral component of plasma membrane|chemical synaptic transmission|central nervous system development|peripheral nervous system development|phototransduction|sensory perception of sound|response to acidic pH|ligand-gated sodium channel activity|monovalent inorganic cation transport|regulation of vasoconstriction|ion transmembrane transport|regulation of ion transmembrane transport|protein localization to synapse|regulation of membrane potential|neuronal cell body|negative regulation of apoptotic process|dendritic spine|acid-sensing ion channel activity|sensory perception of sour taste|detection of mechanical stimulus involved in sensory perception|positive regulation of synapse assembly hsa04742,hsa04750 Taste transduction|Inflammatory mediator regulation of TRP channels ASIC3 14.4136539245496 13.3181717471107 15.5091361019885 1.16450939336723 0.219722276912165 0.814507638162017 1 0.127241 0.130007 0.163377 0.240424 GeneID:9311,Genbank:NM_020321.3,HGNC:HGNC:101,MIM:611741 acid sensing ion channel subunit 3 GO:0005261,GO:0005272,GO:0005737,GO:0005886,GO:0005887,GO:0006810,GO:0007165,GO:0007600,GO:0009408,GO:0010447,GO:0030165,GO:0034220,GO:0042931,GO:0044736,GO:0050915,GO:0050965,GO:0050966,GO:0050968 cation channel activity|sodium channel activity|cytoplasm|plasma membrane|integral component of plasma membrane|transport|signal transduction|sensory perception|response to heat|response to acidic pH|PDZ domain binding|ion transmembrane transport|enterobactin transmembrane transporter activity|acid-sensing ion channel activity|sensory perception of sour taste|detection of temperature stimulus involved in sensory perception of pain|detection of mechanical stimulus involved in sensory perception of pain|detection of chemical stimulus involved in sensory perception of pain hsa04750 Inflammatory mediator regulation of TRP channels ASIC4 2.02057887700968 2.10436443188427 1.93679332213509 0.920369729116198 -0.119714560664903 1 1 0.0156534 0 0 0.0270803 GeneID:55515,Genbank:NM_018674.5,HGNC:HGNC:21263,MIM:606715 acid sensing ion channel subunit family member 4 GO:0005216,GO:0005272,GO:0005887,GO:0006810,GO:0015081 ion channel activity|sodium channel activity|integral component of plasma membrane|transport|sodium ion transmembrane transporter activity hsa04750 Inflammatory mediator regulation of TRP channels ASIC5 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0150757 GeneID:51802,Genbank:XM_017008291.1,HGNC:HGNC:17537,MIM:616693 acid sensing ion channel subunit family member 5 GO:0005886,GO:0015252,GO:0016021,GO:0034220,GO:0044736 plasma membrane|proton channel activity|integral component of membrane|ion transmembrane transport|acid-sensing ion channel activity hsa04750 Inflammatory mediator regulation of TRP channels ASIP 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:434,Genbank:XM_011528821.1,HGNC:HGNC:745,MIM:600201 agouti signaling protein GO:0005102,GO:0005615,GO:0005622,GO:0006091,GO:0007165,GO:0007267,GO:0008343,GO:0009755,GO:0031781,GO:0031782,GO:0032402,GO:0032438,GO:0040030,GO:0042438,GO:0048023,GO:0071514 receptor binding|extracellular space|intracellular|generation of precursor metabolites and energy|signal transduction|cell-cell signaling|adult feeding behavior|hormone-mediated signaling pathway|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|melanosome transport|melanosome organization|regulation of molecular function, epigenetic|melanin biosynthetic process|positive regulation of melanin biosynthetic process|genetic imprinting hsa04916 Melanogenesis ASL 1239.2977925401 1182.79049324391 1295.80509183629 1.09554912661026 0.131654179104857 0.393626858675972 1 18.3623 19.0318 19.8914 22.4002 GeneID:435,Genbank:NM_000048.3,HGNC:HGNC:746,MIM:608310 argininosuccinate lyase GO:0000050,GO:0004056,GO:0005737,GO:0005829,GO:0042450,GO:0042802,GO:0070062 urea cycle|argininosuccinate lyase activity|cytoplasm|cytosol|arginine biosynthetic process via ornithine|identical protein binding|extracellular exosome hsa00220,hsa00250 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism ASMTL 15.7566502265953 24.7240841610769 6.78921629211359 0.274599303573066 -1.86460012829878 0.0125739151686938 0.459780423154794 0.207615 0.0328026 0.157279 0.0163232 GeneID:8623,Genbank:XM_005274434.3,HGNC:HGNC:751,MIM:400011 acetylserotonin O-methyltransferase like GO:0005829,GO:0008171,GO:0047429 cytosol|O-methyltransferase activity|nucleoside-triphosphate diphosphatase activity ASNA1 3510.90650958021 3529.74978345822 3492.06323570221 0.989323167343867 -0.0154862333897408 0.886420183955204 1 92.3099 100.204 94.9482 100.713 GeneID:439,Genbank:NM_004317.3,HGNC:HGNC:752,MIM:601913 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) ASNS 2852.51738118964 2897.49039270176 2807.54436967753 0.968957266173932 -0.0454950548800706 0.844678578381301 1 33.8444 35.793 28.7958 38.2625 GeneID:440,Genbank:NM_001352496.1,HGNC:HGNC:753,MIM:108370 asparagine synthetase (glutamine-hydrolyzing) hsa00250 Alanine, aspartate and glutamate metabolism ASNSD1 332.007062343377 362.088003455606 301.926121231147 0.833847347467187 -0.262144801396921 0.191439349075936 1 9.75958 8.47962 8.39415 7.54806 GeneID:54529,Genbank:NM_019048.3,HGNC:HGNC:24910 asparagine synthetase domain containing 1 GO:0004066,GO:0006529,GO:0006541,GO:0042803 asparagine synthase (glutamine-hydrolyzing) activity|asparagine biosynthetic process|glutamine metabolic process|protein homodimerization activity ASPG 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:374569,Genbank:XM_017021268.1,HGNC:HGNC:20123 asparaginase GO:0003847,GO:0004067,GO:0004622,GO:0005829,GO:0006530,GO:0008652,GO:0016042 1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity|cytosol|asparagine catabolic process|cellular amino acid biosynthetic process|lipid catabolic process ASPH 4141.38830270075 4192.00597858255 4090.77062681895 0.975850379918153 -0.0352681281412945 0.891954266264375 1 7.5025 6.85686 8.24587 5.8308 GeneID:444,Genbank:NM_004318.3,HGNC:HGNC:757,MIM:600582 aspartate beta-hydroxylase GO:0004597,GO:0005198,GO:0005509,GO:0005513,GO:0005623,GO:0005783,GO:0005789,GO:0005886,GO:0006936,GO:0007389,GO:0008285,GO:0008307,GO:0009055,GO:0010524,GO:0010649,GO:0010880,GO:0010881,GO:0014701,GO:0016021,GO:0030176,GO:0031585,GO:0031647,GO:0032237,GO:0032541,GO:0033017,GO:0033018,GO:0033198,GO:0034220,GO:0034704,GO:0035108,GO:0042264,GO:0044325,GO:0045862,GO:0045893,GO:0060021,GO:0060314,GO:0060316,GO:0060325,GO:0070588,GO:0071277,GO:0090316,GO:0097202,GO:1901879,GO:1903779 peptide-aspartate beta-dioxygenase activity|structural molecule activity|calcium ion binding|detection of calcium ion|cell|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|muscle contraction|pattern specification process|negative regulation of cell proliferation|structural constituent of muscle|electron transfer activity|positive regulation of calcium ion transport into cytosol|regulation of cell communication by electrical coupling|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|junctional sarcoplasmic reticulum membrane|integral component of membrane|integral component of endoplasmic reticulum membrane|regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|regulation of protein stability|activation of store-operated calcium channel activity|cortical endoplasmic reticulum|sarcoplasmic reticulum membrane|sarcoplasmic reticulum lumen|response to ATP|ion transmembrane transport|calcium channel complex|limb morphogenesis|peptidyl-aspartic acid hydroxylation|ion channel binding|positive regulation of proteolysis|positive regulation of transcription, DNA-templated|palate development|regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|face morphogenesis|calcium ion transmembrane transport|cellular response to calcium ion|positive regulation of intracellular protein transport|activation of cysteine-type endopeptidase activity|regulation of protein depolymerization|regulation of cardiac conduction ASPHD1 115.065682874323 125.936507646225 104.194858102421 0.827360231356589 -0.27341248152933 0.329291185568238 1 1.37818 1.44667 1.16525 1.11893 GeneID:253982,Genbank:XM_017023107.1,HGNC:HGNC:27380 aspartate beta-hydroxylase domain containing 1 GO:0016021,GO:0018193,GO:0051213 integral component of membrane|peptidyl-amino acid modification|dioxygenase activity ASPHD2 88.5833979653038 92.3529206303381 84.8138753002694 0.918367006927205 -0.122857281921573 0.689939417203023 1 1.21097 1.46952 1.31404 1.15528 GeneID:57168,Genbank:NM_020437.4,HGNC:HGNC:30437 aspartate beta-hydroxylase domain containing 2 GO:0016020,GO:0016021,GO:0018193,GO:0046872,GO:0051213 membrane|integral component of membrane|peptidyl-amino acid modification|metal ion binding|dioxygenase activity ASPM 270.615997274265 259.108416462224 282.123578086306 1.0888244463006 0.122771363725958 0.764918501819419 1 0.787408 0.831478 1.19685 0.642774 GeneID:259266,Genbank:NM_001206846.1,HGNC:HGNC:19048,MIM:605481 abnormal spindle microtubule assembly ASPN 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.01659 0 0 0 GeneID:54829,Genbank:NM_001193335.1,HGNC:HGNC:14872,MIM:608135 asporin GO:0004860,GO:0005509,GO:0005518,GO:0005578,GO:0005737,GO:0006469,GO:0019221,GO:0030282,GO:0030512,GO:0031012,GO:0046426,GO:0070171 protein kinase inhibitor activity|calcium ion binding|collagen binding|proteinaceous extracellular matrix|cytoplasm|negative regulation of protein kinase activity|cytokine-mediated signaling pathway|bone mineralization|negative regulation of transforming growth factor beta receptor signaling pathway|extracellular matrix|negative regulation of JAK-STAT cascade|negative regulation of tooth mineralization ASPRV1 10.4321602215873 11.6558524424989 9.20846800067565 0.790029562067918 -0.340021456469985 0.729626030073425 1 0.178458 0.259978 0.210354 0.156917 GeneID:151516,Genbank:NM_152792.2,HGNC:HGNC:26321,MIM:611765 aspartic peptidase retroviral like 1 GO:0004190,GO:0016021,GO:0016485,GO:0043588 aspartic-type endopeptidase activity|integral component of membrane|protein processing|skin development ASPSCR1 691.059539841196 686.223045899852 695.896033782541 1.01409598226187 0.020194207153772 0.941034793645399 1 6.37711 7.53282 7.73078 7.87908 GeneID:79058,Genbank:NM_001330528.1,HGNC:HGNC:13825,MIM:606236 ASPSCR1, UBX domain containing tether for SLC2A4 hsa05202 Transcriptional misregulation in cancer ASRGL1 206.20366360975 207.89206763098 204.515259588519 0.983756917322813 -0.0236262198685265 0.931661835853913 1 2.41374 2.29547 2.28177 2.12228 GeneID:80150,Genbank:NM_001083926.1,HGNC:HGNC:16448,MIM:609212 asparaginase like 1 GO:0004067,GO:0005634,GO:0005737,GO:0005829,GO:0006559,GO:0008798,GO:0033345 asparaginase activity|nucleus|cytoplasm|cytosol|L-phenylalanine catabolic process|beta-aspartyl-peptidase activity|asparagine catabolic process via L-aspartate ASS1 138.65940639489 130.981300489853 146.337512299927 1.11723972622538 0.159938778237648 0.564752754876758 1 1.9667 1.96234 2.07281 2.59564 GeneID:445,Genbank:NM_000050.4,HGNC:HGNC:758,MIM:603470 argininosuccinate synthase 1 hsa00220,hsa00250,hsa05418 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Fluid shear stress and atherosclerosis ASTE1 65.1333558351427 70.6555087752673 59.6112028950181 0.843687971798807 -0.245218561324248 0.499416011800764 1 0.497987 0.582114 0.477612 0.39633 GeneID:28990,Genbank:NM_001288950.1,HGNC:HGNC:25021 asteroid homolog 1 GO:0004518,GO:0006281 nuclease activity|DNA repair ASTN1 5.74640146212975 5.67894306964064 5.81385985461886 1.0237573758574 0.0338738460783078 1 1 0.024615 0.0188395 0.0116685 0.0254026 GeneID:460,Genbank:XM_017001341.2,HGNC:HGNC:773,MIM:600904 astrotactin 1 GO:0001764,GO:0005768,GO:0007158,GO:0007626,GO:0009897,GO:0016021,GO:0030136,GO:0043204 neuron migration|endosome|neuron cell-cell adhesion|locomotory behavior|external side of plasma membrane|integral component of membrane|clathrin-coated vesicle|perikaryon ASTN2 96.3320929448744 91.3727778264234 101.291408063325 1.10855126081144 0.148675483789862 0.652255711775042 1 0.431969 0.502482 0.503357 0.445785 GeneID:23245,Genbank:NM_014010.4,HGNC:HGNC:17021,MIM:612856 astrotactin 2 GO:0005509,GO:0005769,GO:0005770,GO:0005938,GO:0015031,GO:0016021,GO:0030136,GO:0043204,GO:0043533,GO:0048105,GO:0060187,GO:2000009 calcium ion binding|early endosome|late endosome|cell cortex|protein transport|integral component of membrane|clathrin-coated vesicle|perikaryon|inositol 1,3,4,5 tetrakisphosphate binding|establishment of body hair planar orientation|cell pole|negative regulation of protein localization to cell surface ASXL1 3654.0880723783 3615.21024449412 3692.96590026248 1.02150792084272 0.0307003908711435 0.828540320888867 1 13.2378 13.6884 14.7209 13.2512 GeneID:171023,Genbank:XM_017027706.1,HGNC:HGNC:18318,MIM:612990 additional sex combs like 1, transcriptional regulator ASXL2 522.668451804511 552.866806638511 492.470096970512 0.89075721504205 -0.16689583079965 0.532929736231865 1 1.31098 1.2615 1.41414 0.898525 GeneID:55252,Genbank:NM_018263.5,HGNC:HGNC:23805,MIM:612991 additional sex combs like 2, transcriptional regulator GO:0003677,GO:0005654,GO:0006351,GO:0016579,GO:0035360,GO:0042975,GO:0045600,GO:0045944,GO:0046872 DNA binding|nucleoplasm|transcription, DNA-templated|protein deubiquitination|positive regulation of peroxisome proliferator activated receptor signaling pathway|peroxisome proliferator activated receptor binding|positive regulation of fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ASXL3 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.00344032 GeneID:80816,Genbank:NM_030632.2,HGNC:HGNC:29357,MIM:615115 additional sex combs like 3, transcriptional regulator GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ATAD1 956.593986894852 977.807394057644 935.380579732059 0.956610254142665 -0.0639968388741597 0.706359694607227 1 3.70397 3.57303 3.751 3.42528 GeneID:84896,Genbank:NM_001321968.1,HGNC:HGNC:25903,MIM:614452 ATPase family, AAA domain containing 1 GO:0002092,GO:0005524,GO:0005634,GO:0005739,GO:0005778,GO:0007612,GO:0007613,GO:0016020,GO:0016887,GO:0030054,GO:0045211,GO:0051967 positive regulation of receptor internalization|ATP binding|nucleus|mitochondrion|peroxisomal membrane|learning|memory|membrane|ATPase activity|cell junction|postsynaptic membrane|negative regulation of synaptic transmission, glutamatergic ATAD2 856.43869369053 888.393884838195 824.483502542864 0.928060758424771 -0.107708835861333 0.773149258485052 1 5.91807 4.52482 5.93092 3.95138 GeneID:29028,Genbank:NM_014109.3,HGNC:HGNC:30123,MIM:611941 ATPase family, AAA domain containing 2 GO:0003682,GO:0005524,GO:0005634,GO:0005654,GO:0006325,GO:0006351,GO:0006357,GO:0016887,GO:0031936,GO:0042393,GO:0045893,GO:0045944,GO:0070062 chromatin binding|ATP binding|nucleus|nucleoplasm|chromatin organization|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|ATPase activity|negative regulation of chromatin silencing|histone binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|extracellular exosome ATAD2B 61.0496957574567 63.4583252250697 58.6410662898437 0.92408783373749 -0.113898109831392 0.769647018894296 1 0.116372 0.138617 0.120518 0.116537 GeneID:54454,Genbank:XM_006712030.4,HGNC:HGNC:29230,MIM:615347 ATPase family, AAA domain containing 2B GO:0003682,GO:0005524,GO:0005634,GO:0005654,GO:0016887,GO:0031936,GO:0045944,GO:0070577 chromatin binding|ATP binding|nucleus|nucleoplasm|ATPase activity|negative regulation of chromatin silencing|positive regulation of transcription from RNA polymerase II promoter|lysine-acetylated histone binding ATAD3A 1993.36775940928 2052.12368768388 1934.61183113468 0.942736465031586 -0.0850735622989792 0.528054809208024 1 25.6721 26.9641 25.5282 25.3805 GeneID:55210,Genbank:NM_018188.4,HGNC:HGNC:25567,MIM:612316 ATPase family, AAA domain containing 3A GO:0005524,GO:0005739,GO:0005743,GO:0005886,GO:0030667,GO:0043312,GO:0101003 ATP binding|mitochondrion|mitochondrial inner membrane|plasma membrane|secretory granule membrane|neutrophil degranulation|ficolin-1-rich granule membrane ATAD3B 702.665279008755 658.461463776806 746.869094240703 1.13426393999857 0.181756390385788 0.267738562103633 1 7.27494 7.14544 9.2068 7.45536 GeneID:83858,Genbank:XM_005244806.3,HGNC:HGNC:24007,MIM:612317 ATPase family, AAA domain containing 3B GO:0005524,GO:0005739,GO:0005743,GO:0005886,GO:0030667,GO:0043312,GO:0101003 ATP binding|mitochondrion|mitochondrial inner membrane|plasma membrane|secretory granule membrane|neutrophil degranulation|ficolin-1-rich granule membrane ATAD3C 1.75827308216552 2.54640955915669 0.97013660517434 0.380982156497883 -1.39220466497676 0.672283656149566 1 0.012719 0 0.0237452 0 GeneID:219293,Genbank:NM_001039211.2,HGNC:HGNC:32151,MIM:617227 ATPase family, AAA domain containing 3C GO:0005524,GO:0005739 ATP binding|mitochondrion ATAD5 53.8365599776685 54.8389537436849 52.8341662116521 0.963442272414549 -0.0537298692550944 0.912397417433063 1 0.205841 0.233507 0.276093 0.168234 GeneID:79915,Genbank:XM_011525269.3,HGNC:HGNC:25752,MIM:609534 ATPase family, AAA domain containing 5 GO:0002377,GO:0005524,GO:0005634,GO:0006974,GO:0030890,GO:0048304,GO:1901990 immunoglobulin production|ATP binding|nucleus|cellular response to DNA damage stimulus|positive regulation of B cell proliferation|positive regulation of isotype switching to IgG isotypes|regulation of mitotic cell cycle phase transition ATAT1 538.233229694401 553.098146357682 523.36831303112 0.946248539210731 -0.0797089269753196 0.6361281976424 1 3.08151 3.25984 2.99406 3.02092 GeneID:79969,Genbank:XM_024446558.1,HGNC:HGNC:21186,MIM:615556 alpha tubulin acetyltransferase 1 GO:0004468,GO:0005794,GO:0005829,GO:0005874,GO:0005905,GO:0005925,GO:0007283,GO:0019799,GO:0021542,GO:0030424,GO:0045598,GO:0050662,GO:0060271,GO:0070507,GO:0071929,GO:0072686,GO:0097427,GO:1900227 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|Golgi apparatus|cytosol|microtubule|clathrin-coated pit|focal adhesion|spermatogenesis|tubulin N-acetyltransferase activity|dentate gyrus development|axon|regulation of fat cell differentiation|coenzyme binding|cilium assembly|regulation of microtubule cytoskeleton organization|alpha-tubulin acetylation|mitotic spindle|microtubule bundle|positive regulation of NLRP3 inflammasome complex assembly ATCAY 1.26526514449636 1.07619535328461 1.45433493570811 1.35136704620532 0.434419579785585 1 1 0.00746198 0 0.0139665 0.00652378 GeneID:85300,Genbank:NM_033064.4,HGNC:HGNC:779,MIM:608179 ATCAY, caytaxin GO:0005737,GO:0019894,GO:0030054,GO:0030424,GO:0030425,GO:0031175,GO:0031966,GO:0032880,GO:0043005,GO:0045202,GO:0048311,GO:0050699,GO:2000212 cytoplasm|kinesin binding|cell junction|axon|dendrite|neuron projection development|mitochondrial membrane|regulation of protein localization|neuron projection|synapse|mitochondrion distribution|WW domain binding|negative regulation of glutamate metabolic process ATE1 397.639158031756 442.900741503032 352.37757456048 0.795612970447167 -0.329861299048441 0.117837498836724 1 2.80402 2.75918 2.76359 1.78037 GeneID:11101,Genbank:NM_001288736.1,HGNC:HGNC:782,MIM:607103 arginyltransferase 1 GO:0004057,GO:0005634,GO:0005737,GO:0010498,GO:0016598 arginyltransferase activity|nucleus|cytoplasm|proteasomal protein catabolic process|protein arginylation ATF1 234.840395570698 221.026925933604 248.653865207791 1.12499354618218 0.169916725071046 0.624003501556527 1 1.78184 1.31694 2.19045 1.38522 GeneID:466,Genbank:XM_017019336.1,HGNC:HGNC:783,MIM:123803 activating transcription factor 1 hsa04925,hsa05166,hsa05202 Aldosterone synthesis and secretion|Human T-cell leukemia virus 1 infection|Transcriptional misregulation in cancer ATF2 315.694481735789 322.643176926448 308.74578654513 0.956926439561788 -0.0635200681471355 0.779485380911722 1 2.39674 2.33876 2.68308 1.82318 GeneID:1386,Genbank:NM_001256092.1,HGNC:HGNC:784,MIM:123811 activating transcription factor 2 GO:0000122,GO:0000977,GO:0000980,GO:0001077,GO:0001102,GO:0001158,GO:0003151,GO:0003677,GO:0003682,GO:0003700,GO:0004402,GO:0005634,GO:0005654,GO:0005737,GO:0005741,GO:0006355,GO:0006970,GO:0006974,GO:0008140,GO:0009414,GO:0010628,GO:0016020,GO:0016525,GO:0019901,GO:0031573,GO:0032915,GO:0035497,GO:0035861,GO:0043525,GO:0043565,GO:0045444,GO:0045944,GO:0046872,GO:0046982,GO:0050680,GO:0051091,GO:0060612,GO:0097186,GO:0110024,GO:1902110 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|enhancer sequence-specific DNA binding|outflow tract morphogenesis|DNA binding|chromatin binding|DNA binding transcription factor activity|histone acetyltransferase activity|nucleus|nucleoplasm|cytoplasm|mitochondrial outer membrane|regulation of transcription, DNA-templated|response to osmotic stress|cellular response to DNA damage stimulus|cAMP response element binding protein binding|response to water deprivation|positive regulation of gene expression|membrane|negative regulation of angiogenesis|protein kinase binding|intra-S DNA damage checkpoint|positive regulation of transforming growth factor beta2 production|cAMP response element binding|site of double-strand break|positive regulation of neuron apoptotic process|sequence-specific DNA binding|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|protein heterodimerization activity|negative regulation of epithelial cell proliferation|positive regulation of DNA binding transcription factor activity|adipose tissue development|amelogenesis|positive regulation of cardiac muscle myoblast proliferation|positive regulation of mitochondrial membrane permeability involved in apoptotic process hsa04010,hsa04022,hsa04151,hsa04211,hsa04261,hsa04668,hsa04714,hsa04728,hsa04911,hsa04915,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05164,hsa05166,hsa05203 MAPK signaling pathway|cGMP-PKG signaling pathway|PI3K-Akt signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human T-cell leukemia virus 1 infection|Viral carcinogenesis ATF3 258.327740630366 242.36955355652 274.285927704212 1.13168475033004 0.178472127359766 0.40153315489033 1 2.77499 3.03162 3.14797 3.43837 GeneID:467,Genbank:NM_001030287.3,HGNC:HGNC:785,MIM:603148 activating transcription factor 3 hsa05166 Human T-cell leukemia virus 1 infection ATF4 6389.78993180407 6654.50376015008 6125.07610345807 0.920440700648118 -0.119603315883213 0.505453043955779 1 33.614 36.4403 30.3983 35.077 GeneID:468,Genbank:XM_017028807.2,HGNC:HGNC:786,MIM:604064 activating transcription factor 4 hsa04010,hsa04022,hsa04137,hsa04141,hsa04151,hsa04210,hsa04211,hsa04261,hsa04668,hsa04720,hsa04722,hsa04725,hsa04728,hsa04911,hsa04912,hsa04915,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04932,hsa04934,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05166,hsa05203,hsa05215 MAPK signaling pathway|cGMP-PKG signaling pathway|Mitophagy - animal|Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Non-alcoholic fatty liver disease (NAFLD)|Cushing syndrome|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis|Prostate cancer ATF5 747.100065224711 766.841644846827 727.358485602595 0.948511978307962 -0.0762621020240674 0.650681489095393 1 9.00829 8.44782 7.78687 9.05912 GeneID:22809,Genbank:NM_012068.5,HGNC:HGNC:790,MIM:606398 activating transcription factor 5 ATF6 1728.00942745121 1576.02051835987 1879.99833654256 1.1928768151439 0.254445067880657 0.072618863944305 0.929707214174252 6.67098 6.69828 8.84745 7.07169 GeneID:22926,Genbank:NM_007348.3,HGNC:HGNC:791,MIM:605537 activating transcription factor 6 GO:0000139,GO:0000976,GO:0000977,GO:0000978,GO:0001077,GO:0001228,GO:0001654,GO:0003700,GO:0003713,GO:0005634,GO:0005635,GO:0005654,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006357,GO:0006457,GO:0006950,GO:0006990,GO:0007165,GO:0007601,GO:0016020,GO:0030176,GO:0030968,GO:0031625,GO:0035497,GO:0036500,GO:0042802,GO:0043065,GO:0043565,GO:0045944,GO:0046982,GO:1990440 Golgi membrane|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|eye development|DNA binding transcription factor activity|transcription coactivator activity|nucleus|nuclear envelope|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|regulation of transcription from RNA polymerase II promoter|protein folding|response to stress|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|signal transduction|visual perception|membrane|integral component of endoplasmic reticulum membrane|endoplasmic reticulum unfolded protein response|ubiquitin protein ligase binding|cAMP response element binding|ATF6-mediated unfolded protein response|identical protein binding|positive regulation of apoptotic process|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress hsa04141,hsa05010 Protein processing in endoplasmic reticulum|Alzheimer disease ATF6B 2070.35325652754 1959.96185515142 2180.74465790366 1.11264647940568 0.153995278731739 0.277017868440154 1 25.2265 24.9277 27.8929 28.7705 GeneID:1388,Genbank:NM_001136153.1,HGNC:HGNC:2349,MIM:600984 activating transcription factor 6 beta GO:0003700,GO:0005622,GO:0005634,GO:0005730,GO:0005789,GO:0005794,GO:0006351,GO:0006366,GO:0007165,GO:0030176,GO:0032993,GO:0035497,GO:0036500,GO:0044212,GO:0045944,GO:0090575,GO:1990440 DNA binding transcription factor activity|intracellular|nucleus|nucleolus|endoplasmic reticulum membrane|Golgi apparatus|transcription, DNA-templated|transcription from RNA polymerase II promoter|signal transduction|integral component of endoplasmic reticulum membrane|protein-DNA complex|cAMP response element binding|ATF6-mediated unfolded protein response|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor complex|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress hsa04022,hsa04141,hsa04151,hsa04211,hsa04261,hsa04668,hsa04728,hsa04911,hsa04915,hsa04918,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05203 cGMP-PKG signaling pathway|Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Thyroid hormone synthesis|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Viral carcinogenesis ATF7 751.256593131822 686.298464138151 816.214722125494 1.18929993985997 0.250112606738771 0.211811233437017 1 2.91567 2.7576 4.06859 2.89183 GeneID:11016,Genbank:XM_005268587.3,HGNC:HGNC:792,MIM:606371 activating transcription factor 7 GO:0003677,GO:0003700,GO:0005654,GO:0006351,GO:0034399,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|nuclear periphery|metal ion binding ATF7IP 622.028298659013 584.83610062447 659.220496693557 1.12718844816464 0.172728731574786 0.58101300369579 1 1.81936 1.78419 2.47648 1.573 GeneID:55729,Genbank:NM_018179.4,HGNC:HGNC:20092,MIM:613644 activating transcription factor 7 interacting protein GO:0000122,GO:0003714,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006306,GO:0006351,GO:0016032,GO:0016604,GO:0016887,GO:0045892,GO:0045893,GO:0045898 negative regulation of transcription from RNA polymerase II promoter|transcription corepressor activity|nucleus|nucleoplasm|transcription factor complex|cytosol|DNA methylation|transcription, DNA-templated|viral process|nuclear body|ATPase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of RNA polymerase II transcriptional preinitiation complex assembly ATG10 296.045632614519 286.282857633088 305.808407595951 1.06820369939121 0.0951867856768087 0.640553404085788 1 1.22182 1.32304 1.33959 1.27496 GeneID:83734,Genbank:XM_017009944.1,HGNC:HGNC:20315,MIM:610800 autophagy related 10 GO:0005622,GO:0005829,GO:0006497,GO:0006914,GO:0006983,GO:0015031,GO:0016236,GO:0016874,GO:0019777,GO:0031401,GO:0032446 intracellular|cytosol|protein lipidation|autophagy|ER overload response|protein transport|macroautophagy|ligase activity|Atg12 transferase activity|positive regulation of protein modification process|protein modification by small protein conjugation hsa04136,hsa04140 Autophagy - other|Autophagy - animal ATG101 1062.84504836125 1057.63221464776 1068.05788207474 1.0098575547176 0.0141518082289696 0.944148729969951 1 32.529 33.4094 33.0591 35.5518 GeneID:60673,Genbank:XM_024449120.1,HGNC:HGNC:25679,MIM:615089 autophagy related 101 GO:0000045,GO:0000407,GO:0005789,GO:0005829,GO:0016236,GO:0016241,GO:0032403,GO:0042802 autophagosome assembly|phagophore assembly site|endoplasmic reticulum membrane|cytosol|macroautophagy|regulation of macroautophagy|protein complex binding|identical protein binding hsa04136,hsa04140,hsa04211 Autophagy - other|Autophagy - animal|Longevity regulating pathway ATG12 1092.76684800848 1249.27345677328 936.26023924368 0.749443794044841 -0.41610781030112 0.00617941486650377 0.314188915879125 12.1466 11.7912 8.74645 9.29606 GeneID:9140,Genbank:NM_001277783.1,HGNC:HGNC:588,MIM:609608 autophagy related 12 GO:0000045,GO:0000422,GO:0005776,GO:0005829,GO:0006501,GO:0016236,GO:0019776,GO:0030670,GO:0034045,GO:0034274,GO:0044804 autophagosome assembly|autophagy of mitochondrion|autophagosome|cytosol|C-terminal protein lipidation|macroautophagy|Atg8 ligase activity|phagocytic vesicle membrane|phagophore assembly site membrane|Atg12-Atg5-Atg16 complex|autophagy of nucleus hsa04068,hsa04136,hsa04140,hsa04621,hsa04622 FoxO signaling pathway|Autophagy - other|Autophagy - animal|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway ATG13 3057.79726782548 2886.07467163268 3229.51986401828 1.11900079916897 0.162211066659876 0.239530748341672 1 11.4018 12.0099 13.5197 13.4661 GeneID:9776,Genbank:NM_001346319.1,HGNC:HGNC:29091,MIM:615088 autophagy related 13 GO:0000045,GO:0000407,GO:0000423,GO:0005739,GO:0005789,GO:0005829,GO:0016236,GO:0016241,GO:0019901,GO:0098780,GO:1903955,GO:1990316 autophagosome assembly|phagophore assembly site|mitophagy|mitochondrion|endoplasmic reticulum membrane|cytosol|macroautophagy|regulation of macroautophagy|protein kinase binding|response to mitochondrial depolarisation|positive regulation of protein targeting to mitochondrion|Atg1/ULK1 kinase complex hsa04136,hsa04140,hsa04211 Autophagy - other|Autophagy - animal|Longevity regulating pathway ATG14 208.554659913196 204.855586669866 212.253733156525 1.0361139601166 0.0511826909136603 0.825175516213397 1 1.58746 1.47835 1.58423 1.73487 GeneID:22863,Genbank:NM_014924.4,HGNC:HGNC:19962,MIM:613515 autophagy related 14 GO:0000045,GO:0000421,GO:0000423,GO:0001932,GO:0001933,GO:0001934,GO:0005776,GO:0005789,GO:0005829,GO:0005930,GO:0008333,GO:0009267,GO:0010608,GO:0016236,GO:0016240,GO:0031410,GO:0034045,GO:0035032,GO:0042149,GO:0043552,GO:0051020,GO:0061635,GO:0097629,GO:0097632,GO:0098780 autophagosome assembly|autophagosome membrane|mitophagy|regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|autophagosome|endoplasmic reticulum membrane|cytosol|axoneme|endosome to lysosome transport|cellular response to starvation|posttranscriptional regulation of gene expression|macroautophagy|autophagosome membrane docking|cytoplasmic vesicle|phagophore assembly site membrane|phosphatidylinositol 3-kinase complex, class III|cellular response to glucose starvation|positive regulation of phosphatidylinositol 3-kinase activity|GTPase binding|regulation of protein complex stability|extrinsic component of omegasome membrane|extrinsic component of phagophore assembly site membrane|response to mitochondrial depolarisation hsa04140,hsa05167 Autophagy - animal|Kaposi sarcoma-associated herpesvirus infection ATG16L1 762.657312147934 799.330436200068 725.9841880958 0.908240391229254 -0.138853897224014 0.380316796559553 1 8.51388 8.90366 8.46593 7.68947 GeneID:55054,Genbank:NM_030803.6,HGNC:HGNC:21498,MIM:610767 autophagy related 16 like 1 GO:0000045,GO:0000421,GO:0005776,GO:0005829,GO:0005930,GO:0015031,GO:0016236,GO:0019787,GO:0034045,GO:0034497,GO:0039689,GO:0042802,GO:0051020,GO:0051260,GO:0061739,GO:0098792 autophagosome assembly|autophagosome membrane|autophagosome|cytosol|axoneme|protein transport|macroautophagy|ubiquitin-like protein transferase activity|phagophore assembly site membrane|protein localization to phagophore assembly site|negative stranded viral RNA replication|identical protein binding|GTPase binding|protein homooligomerization|protein lipidation involved in autophagosome assembly|xenophagy hsa04136,hsa04140,hsa04621 Autophagy - other|Autophagy - animal|NOD-like receptor signaling pathway ATG16L2 103.622704701961 99.1560853279483 108.089324075973 1.09009269293437 0.124450815691192 0.698016465124421 1 0.348005 0.351694 0.403516 0.323957 GeneID:89849,Genbank:NM_001318766.1,HGNC:HGNC:25464 autophagy related 16 like 2 GO:0000045,GO:0000421,GO:0005654,GO:0015031,GO:0039689 autophagosome assembly|autophagosome membrane|nucleoplasm|protein transport|negative stranded viral RNA replication hsa04140 Autophagy - animal ATG2A 743.739548680295 769.273401547253 718.205695813337 0.933615661699466 -0.0990993319712464 0.529821047427545 1 4.33973 4.36173 4.01469 4.21676 GeneID:23130,Genbank:NM_015104.2,HGNC:HGNC:29028,MIM:616225 autophagy related 2A GO:0000045,GO:0000407,GO:0000422,GO:0005634,GO:0005811,GO:0005829,GO:0019898,GO:0034045,GO:0043231,GO:0044804 autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|nucleus|lipid droplet|cytosol|extrinsic component of membrane|phagophore assembly site membrane|intracellular membrane-bounded organelle|autophagy of nucleus hsa04136,hsa04140 Autophagy - other|Autophagy - animal ATG2B 302.791961076389 327.832048594131 277.751873558648 0.847238318369891 -0.239160254763825 0.473940067851928 1 0.936473 0.832572 0.937647 0.57445 GeneID:55102,Genbank:NM_018036.6,HGNC:HGNC:20187,MIM:616226 autophagy related 2B GO:0000045,GO:0000407,GO:0000422,GO:0005654,GO:0005811,GO:0019898,GO:0034045,GO:0044804 autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|nucleoplasm|lipid droplet|extrinsic component of membrane|phagophore assembly site membrane|autophagy of nucleus hsa04136,hsa04140 Autophagy - other|Autophagy - animal ATG3 1065.36369133757 1115.41057980233 1015.3168028728 0.910262840659744 -0.135644907637818 0.371676376487636 1 12.0047 12.781 11.8167 10.8328 GeneID:64422,Genbank:NM_022488.4,HGNC:HGNC:20962,MIM:609606 autophagy related 3 GO:0000045,GO:0000153,GO:0000422,GO:0005829,GO:0006464,GO:0006612,GO:0016236,GO:0016567,GO:0016874,GO:0019776,GO:0019777,GO:0019787,GO:0019899,GO:0043653,GO:0044804,GO:0050765,GO:1902017 autophagosome assembly|cytoplasmic ubiquitin ligase complex|autophagy of mitochondrion|cytosol|cellular protein modification process|protein targeting to membrane|macroautophagy|protein ubiquitination|ligase activity|Atg8 ligase activity|Atg12 transferase activity|ubiquitin-like protein transferase activity|enzyme binding|mitochondrial fragmentation involved in apoptotic process|autophagy of nucleus|negative regulation of phagocytosis|regulation of cilium assembly hsa04136,hsa04140,hsa05167 Autophagy - other|Autophagy - animal|Kaposi sarcoma-associated herpesvirus infection ATG4A 459.205840436299 443.016411362617 475.39526950998 1.07308726565631 0.101767403783459 0.573323545487104 1 4.2878 4.5113 4.5684 4.84251 GeneID:115201,Genbank:NM_001321287.1,HGNC:HGNC:16489,MIM:300663 autophagy related 4A cysteine peptidase GO:0000045,GO:0000422,GO:0004197,GO:0005737,GO:0005829,GO:0006501,GO:0006508,GO:0006612,GO:0008234,GO:0044804,GO:0051697 autophagosome assembly|autophagy of mitochondrion|cysteine-type endopeptidase activity|cytoplasm|cytosol|C-terminal protein lipidation|proteolysis|protein targeting to membrane|cysteine-type peptidase activity|autophagy of nucleus|protein delipidation hsa04136,hsa04140 Autophagy - other|Autophagy - animal ATG4B 1062.99689860173 1111.6645303769 1014.32926682656 0.912441873523351 -0.132195438966941 0.366473900391833 1 6.31102 6.72035 6.24239 6.35692 GeneID:23192,Genbank:NM_178326.2,HGNC:HGNC:20790,MIM:611338 autophagy related 4B cysteine peptidase GO:0000045,GO:0000422,GO:0004175,GO:0004197,GO:0005737,GO:0005829,GO:0006501,GO:0006508,GO:0006612,GO:0006914,GO:0008234,GO:0016236,GO:0044804,GO:0045732,GO:0051697 autophagosome assembly|autophagy of mitochondrion|endopeptidase activity|cysteine-type endopeptidase activity|cytoplasm|cytosol|C-terminal protein lipidation|proteolysis|protein targeting to membrane|autophagy|cysteine-type peptidase activity|macroautophagy|autophagy of nucleus|positive regulation of protein catabolic process|protein delipidation hsa04136,hsa04140 Autophagy - other|Autophagy - animal ATG4C 110.449682021694 124.936747532094 95.9626165112937 0.768089600592833 -0.380653478223559 0.195671239252133 1 0.891458 0.827797 0.878205 0.658483 GeneID:84938,Genbank:XM_024450414.1,HGNC:HGNC:16040,MIM:611339 autophagy related 4C cysteine peptidase GO:0000045,GO:0000422,GO:0004197,GO:0005576,GO:0005737,GO:0005829,GO:0006501,GO:0006508,GO:0006612,GO:0006914,GO:0008233,GO:0044804,GO:0051697 autophagosome assembly|autophagy of mitochondrion|cysteine-type endopeptidase activity|extracellular region|cytoplasm|cytosol|C-terminal protein lipidation|proteolysis|protein targeting to membrane|autophagy|peptidase activity|autophagy of nucleus|protein delipidation hsa04136,hsa04140 Autophagy - other|Autophagy - animal ATG4D 1055.06406860307 1039.62403428917 1070.50410291696 1.02970311151848 0.0422284332516719 0.783947229919962 1 23.5605 21.4079 21.9198 24.2223 GeneID:84971,Genbank:NM_001281504.1,HGNC:HGNC:20789,MIM:611340 autophagy related 4D cysteine peptidase GO:0000045,GO:0000422,GO:0004197,GO:0005737,GO:0005759,GO:0005829,GO:0006501,GO:0006612,GO:0006915,GO:0044804,GO:0051697 autophagosome assembly|autophagy of mitochondrion|cysteine-type endopeptidase activity|cytoplasm|mitochondrial matrix|cytosol|C-terminal protein lipidation|protein targeting to membrane|apoptotic process|autophagy of nucleus|protein delipidation hsa04136,hsa04140 Autophagy - other|Autophagy - animal ATG5 844.41520083935 902.74124266476 786.089159013939 0.870780154780033 -0.199619566238916 0.219055416708275 1 10.7619 9.37186 9.8596 8.39496 GeneID:9474,Genbank:NM_001286111.1,HGNC:HGNC:589,MIM:604261 autophagy related 5 GO:0000045,GO:0000422,GO:0001974,GO:0002739,GO:0005737,GO:0005776,GO:0005829,GO:0005930,GO:0006501,GO:0006914,GO:0006915,GO:0006995,GO:0009620,GO:0016020,GO:0016236,GO:0019725,GO:0019883,GO:0030670,GO:0031397,GO:0034045,GO:0034274,GO:0035973,GO:0039689,GO:0042311,GO:0042493,GO:0043066,GO:0043687,GO:0044233,GO:0044804,GO:0045060,GO:0048840,GO:0050765,GO:0051279,GO:0055015,GO:0060047,GO:0060548,GO:0061739,GO:0070257,GO:0071500,GO:0075044,GO:1902017,GO:2000378,GO:2000619 autophagosome assembly|autophagy of mitochondrion|blood vessel remodeling|regulation of cytokine secretion involved in immune response|cytoplasm|autophagosome|cytosol|axoneme|C-terminal protein lipidation|autophagy|apoptotic process|cellular response to nitrogen starvation|response to fungus|membrane|macroautophagy|cellular homeostasis|antigen processing and presentation of endogenous antigen|phagocytic vesicle membrane|negative regulation of protein ubiquitination|phagophore assembly site membrane|Atg12-Atg5-Atg16 complex|aggrephagy|negative stranded viral RNA replication|vasodilation|response to drug|negative regulation of apoptotic process|post-translational protein modification|ER-mitochondrion membrane contact site|autophagy of nucleus|negative thymic T cell selection|otolith development|negative regulation of phagocytosis|regulation of release of sequestered calcium ion into cytosol|ventricular cardiac muscle cell development|heart contraction|negative regulation of cell death|protein lipidation involved in autophagosome assembly|positive regulation of mucus secretion|cellular response to nitrosative stress|autophagy of host cells involved in interaction with symbiont|regulation of cilium assembly|negative regulation of reactive oxygen species metabolic process|negative regulation of histone H4-K16 acetylation hsa04136,hsa04137,hsa04140,hsa04211,hsa04213,hsa04216,hsa04621,hsa04622,hsa05131 Autophagy - other|Mitophagy - animal|Autophagy - animal|Longevity regulating pathway|Longevity regulating pathway - multiple species|Ferroptosis|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Shigellosis ATG7 1241.99731614866 1300.04979447896 1183.94483781835 0.910691915683781 -0.13496501768597 0.353290833561698 1 4.51966 4.90714 4.48087 4.28711 GeneID:10533,Genbank:NM_001349238.1,HGNC:HGNC:16935,MIM:608760 autophagy related 7 GO:0000045,GO:0000407,GO:0000422,GO:0004839,GO:0005576,GO:0005737,GO:0005829,GO:0005930,GO:0006464,GO:0006497,GO:0006501,GO:0006914,GO:0006995,GO:0007568,GO:0008134,GO:0009267,GO:0009749,GO:0010508,GO:0015031,GO:0016236,GO:0019778,GO:0019779,GO:0030424,GO:0031401,GO:0034727,GO:0034774,GO:0039521,GO:0042803,GO:0043065,GO:0043312,GO:0044805,GO:0045732,GO:0051607,GO:0061025,GO:0071315,GO:0071455,GO:0075044,GO:0090298,GO:1902617,GO:1903204,GO:1904813 autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|ubiquitin activating enzyme activity|extracellular region|cytoplasm|cytosol|axoneme|cellular protein modification process|protein lipidation|C-terminal protein lipidation|autophagy|cellular response to nitrogen starvation|aging|transcription factor binding|cellular response to starvation|response to glucose|positive regulation of autophagy|protein transport|macroautophagy|Atg12 activating enzyme activity|Atg8 activating enzyme activity|axon|positive regulation of protein modification process|piecemeal microautophagy of the nucleus|secretory granule lumen|suppression by virus of host autophagy|protein homodimerization activity|positive regulation of apoptotic process|neutrophil degranulation|late nucleophagy|positive regulation of protein catabolic process|defense response to virus|membrane fusion|cellular response to morphine|cellular response to hyperoxia|autophagy of host cells involved in interaction with symbiont|negative regulation of mitochondrial DNA replication|response to fluoride|negative regulation of oxidative stress-induced neuron death|ficolin-1-rich granule lumen hsa04136,hsa04140,hsa04216 Autophagy - other|Autophagy - animal|Ferroptosis ATG9A 3048.47224245324 3018.62325587863 3078.32122902784 1.01977655642616 0.0282530774422421 0.85589995061687 1 34.8403 36.646 36.739 36.909 GeneID:79065,Genbank:NM_024085.4,HGNC:HGNC:22408,MIM:612204 autophagy related 9A GO:0000045,GO:0000407,GO:0000422,GO:0005768,GO:0005770,GO:0005776,GO:0005789,GO:0005802,GO:0015031,GO:0016020,GO:0016021,GO:0031667,GO:0031902,GO:0034497,GO:0043231,GO:0044805,GO:0055037 autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|endosome|late endosome|autophagosome|endoplasmic reticulum membrane|trans-Golgi network|protein transport|membrane|integral component of membrane|response to nutrient levels|late endosome membrane|protein localization to phagophore assembly site|intracellular membrane-bounded organelle|late nucleophagy|recycling endosome hsa04136,hsa04137,hsa04140 Autophagy - other|Mitophagy - animal|Autophagy - animal ATG9B 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0.0111655 0.020895 GeneID:285973,Genbank:XM_011516066.3,HGNC:HGNC:21899,MIM:612205 autophagy related 9B GO:0000045,GO:0000407,GO:0000421,GO:0000422,GO:0005776,GO:0016021,GO:0031410,GO:0034497,GO:0044805 autophagosome assembly|phagophore assembly site|autophagosome membrane|autophagy of mitochondrion|autophagosome|integral component of membrane|cytoplasmic vesicle|protein localization to phagophore assembly site|late nucleophagy hsa04136,hsa04137,hsa04140 Autophagy - other|Mitophagy - animal|Autophagy - animal ATIC 2165.12367083056 2161.07037539501 2169.17696626611 1.00375119244769 0.00540170165276732 0.983083758564497 1 29.4993 31.9033 31.3253 29.9197 GeneID:471,Genbank:NM_004044.6,HGNC:HGNC:794,MIM:601731 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase hsa00230,hsa00670,hsa01523 Purine metabolism|One carbon pool by folate|Antifolate resistance ATL1 156.567990112458 159.010405949938 154.125574274977 0.969279798729032 -0.0450149112170593 0.899517240379879 1 1.9713 1.58621 2.0388 1.56025 GeneID:51062,Genbank:NM_001127713.1,HGNC:HGNC:11231,MIM:606439 atlastin GTPase 1 GO:0000137,GO:0000139,GO:0003924,GO:0005525,GO:0005783,GO:0005789,GO:0005794,GO:0007029,GO:0007409,GO:0016021,GO:0030424,GO:0042802,GO:0051260,GO:0071782,GO:0098826,GO:1990809 Golgi cis cisterna|Golgi membrane|GTPase activity|GTP binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|endoplasmic reticulum organization|axonogenesis|integral component of membrane|axon|identical protein binding|protein homooligomerization|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network membrane|endoplasmic reticulum tubular network membrane organization ATL2 779.339634849656 857.328298416996 701.350971282315 0.818065812801603 -0.289711183281272 0.313239592105335 1 5.00279 4.19988 4.45608 3.39663 GeneID:64225,Genbank:NM_001330462.1,HGNC:HGNC:24047,MIM:609368 atlastin GTPase 2 GO:0003924,GO:0005525,GO:0005783,GO:0007029,GO:0007030,GO:0016020,GO:0016021,GO:0042802,GO:0051260,GO:0098826,GO:1990809 GTPase activity|GTP binding|endoplasmic reticulum|endoplasmic reticulum organization|Golgi organization|membrane|integral component of membrane|identical protein binding|protein homooligomerization|endoplasmic reticulum tubular network membrane|endoplasmic reticulum tubular network membrane organization ATL3 1625.20286100798 1585.55238906027 1664.85333295568 1.05001471060973 0.0704095400580992 0.621330962774807 1 9.38933 9.38827 11.3754 8.60431 GeneID:25923,Genbank:NM_001290048.1,HGNC:HGNC:24526,MIM:609369 atlastin GTPase 3 GO:0003924,GO:0005525,GO:0005783,GO:0007029,GO:0007030,GO:0016020,GO:0016021,GO:0042802,GO:0051260,GO:0071782,GO:0098826,GO:1903373 GTPase activity|GTP binding|endoplasmic reticulum|endoplasmic reticulum organization|Golgi organization|membrane|integral component of membrane|identical protein binding|protein homooligomerization|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network membrane|positive regulation of endoplasmic reticulum tubular network organization ATM 199.842773054917 172.328577697049 227.356968412786 1.31932249108721 0.399797255586208 0.457872116597177 1 0.438783 0.353747 0.695654 0.308591 GeneID:472,Genbank:XM_011542843.2,HGNC:HGNC:795,MIM:607585 ATM serine/threonine kinase hsa01524,hsa03440,hsa04064,hsa04068,hsa04110,hsa04115,hsa04210,hsa04218,hsa05165,hsa05166,hsa05170,hsa05202,hsa05206 Platinum drug resistance|Homologous recombination|NF-kappa B signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Apoptosis|Cellular senescence|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Transcriptional misregulation in cancer|MicroRNAs in cancer ATMIN 970.04696374893 987.272638173996 952.821289323863 0.965104523798155 -0.0512428957199878 0.762424024260702 1 7.5659 6.88523 7.58168 6.50833 GeneID:23300,Genbank:NM_015251.2,HGNC:HGNC:29034,MIM:614693 ATM interactor GO:0006351,GO:0006974,GO:0016604,GO:0044212,GO:0044458,GO:0045893,GO:0046872,GO:0070840,GO:1902857 transcription, DNA-templated|cellular response to DNA damage stimulus|nuclear body|transcription regulatory region DNA binding|motile cilium assembly|positive regulation of transcription, DNA-templated|metal ion binding|dynein complex binding|positive regulation of non-motile cilium assembly ATN1 3548.91663553256 3469.43278339788 3628.40048766723 1.04581950831561 0.0646338870278244 0.649456765798215 1 28.4755 29.6315 31.5671 30.5049 GeneID:1822,Genbank:NM_001007026.1,HGNC:HGNC:3033,MIM:607462 atrophin 1 GO:0000122,GO:0003677,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0007417,GO:0016363,GO:0019904,GO:0030054,GO:0048471,GO:0051402 negative regulation of transcription from RNA polymerase II promoter|DNA binding|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|central nervous system development|nuclear matrix|protein domain specific binding|cell junction|perinuclear region of cytoplasm|neuron apoptotic process ATOH1 0.998282869833606 1.02816907859967 0.968396661067546 0.941865186596032 -0.0864075197076174 1 1 0.0671858 0.0559733 0 0.113817 GeneID:474,Genbank:NM_005172.1,HGNC:HGNC:797,MIM:601461 atonal bHLH transcription factor 1 GO:0000978,GO:0001077,GO:0001764,GO:0003700,GO:0005634,GO:0006366,GO:0007219,GO:0007411,GO:0007417,GO:0021987,GO:0031490,GO:0042472,GO:0042667,GO:0042668,GO:0043066,GO:0045609,GO:0045666,GO:0046983 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|neuron migration|DNA binding transcription factor activity|nucleus|transcription from RNA polymerase II promoter|Notch signaling pathway|axon guidance|central nervous system development|cerebral cortex development|chromatin DNA binding|inner ear morphogenesis|auditory receptor cell fate specification|auditory receptor cell fate determination|negative regulation of apoptotic process|positive regulation of inner ear auditory receptor cell differentiation|positive regulation of neuron differentiation|protein dimerization activity ATOH7 2.26648455004176 2.59443583384164 1.93853326624189 0.747188749459823 -0.420455362565587 0.964658570328397 1 0.156337 0.0926659 0.0969122 0.0907397 GeneID:220202,Genbank:NM_145178.3,HGNC:HGNC:13907,MIM:609875 atonal bHLH transcription factor 7 GO:0003407,GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0007623,GO:0009649,GO:0021554,GO:0030154,GO:0046983 neural retina development|DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|circadian rhythm|entrainment of circadian clock|optic nerve development|cell differentiation|protein dimerization activity ATOH8 65.2318712156133 56.8090480066222 73.6546944246043 1.2965310458295 0.374656752375555 0.369097711966538 1 0.26875 0.438189 0.426733 0.529032 GeneID:84913,Genbank:XM_011533139.1,HGNC:HGNC:24126 atonal bHLH transcription factor 8 GO:0001704,GO:0001937,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0007399,GO:0010595,GO:0016607,GO:0030154,GO:0033613,GO:0035148,GO:0045603,GO:0045892,GO:0045893,GO:0046983,GO:0051450,GO:0060395,GO:0070888 formation of primary germ layer|negative regulation of endothelial cell proliferation|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|nervous system development|positive regulation of endothelial cell migration|nuclear speck|cell differentiation|activating transcription factor binding|tube formation|positive regulation of endothelial cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|myoblast proliferation|SMAD protein signal transduction|E-box binding ATOX1 978.932881990355 949.914592768215 1007.95117121249 1.06109662793489 0.0855560401309924 0.600485554654839 1 92.9582 99.2948 95.5882 104.216 GeneID:475,Genbank:NM_004045.3,HGNC:HGNC:798,MIM:602270 antioxidant 1 copper chaperone hsa04978 Mineral absorption ATP10A 26.7381325211009 14.2022620016556 39.2740030405462 2.76533435560955 1.46745392675902 0.243020133585764 1 0.0463266 0.0669649 0.265518 0.0656829 GeneID:57194,Genbank:XM_011521828.2,HGNC:HGNC:13542,MIM:605855 ATPase phospholipid transporting 10A (putative) GO:0000287,GO:0004012,GO:0005524,GO:0005783,GO:0005789,GO:0005886,GO:0008360,GO:0016021,GO:0034220,GO:0045332 magnesium ion binding|phospholipid-translocating ATPase activity|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|regulation of cell shape|integral component of membrane|ion transmembrane transport|phospholipid translocation ATP10D 565.722400486228 539.634878785662 591.809922186794 1.09668582490172 0.133150286202234 0.545202356719055 1 3.03228 2.70903 3.79373 2.68222 GeneID:57205,Genbank:XM_005248119.4,HGNC:HGNC:13549 ATPase phospholipid transporting 10D (putative) GO:0000287,GO:0004012,GO:0005524,GO:0005654,GO:0005783,GO:0005789,GO:0005886,GO:0006812,GO:0016021,GO:0034220,GO:0045332 magnesium ion binding|phospholipid-translocating ATPase activity|ATP binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|cation transport|integral component of membrane|ion transmembrane transport|phospholipid translocation ATP11A 598.728086524894 641.01099840508 556.445174644708 0.868074301422622 -0.204109561772613 0.386396414937977 1 2.14119 2.05035 2.27113 1.47966 GeneID:23250,Genbank:XM_005268299.4,HGNC:HGNC:13552,MIM:605868 ATPase phospholipid transporting 11A GO:0000287,GO:0004012,GO:0005524,GO:0005765,GO:0005769,GO:0005783,GO:0005886,GO:0016020,GO:0016021,GO:0035579,GO:0043231,GO:0043312,GO:0045332,GO:0055037,GO:0070821 magnesium ion binding|phospholipid-translocating ATPase activity|ATP binding|lysosomal membrane|early endosome|endoplasmic reticulum|plasma membrane|membrane|integral component of membrane|specific granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|phospholipid translocation|recycling endosome|tertiary granule membrane ATP11B 904.912678431068 934.940859369037 874.8844974931 0.935764533901677 -0.0957825442547353 0.751225444734352 1 3.0477 2.51865 3.2012 2.15238 GeneID:23200,Genbank:NM_014616.2,HGNC:HGNC:13553,MIM:605869 ATPase phospholipid transporting 11B (putative) GO:0000287,GO:0004012,GO:0005524,GO:0005637,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0006811,GO:0015075,GO:0015917,GO:0016020,GO:0016021,GO:0034220,GO:0035577,GO:0043312,GO:0045332,GO:0055037,GO:0055038 magnesium ion binding|phospholipid-translocating ATPase activity|ATP binding|nuclear inner membrane|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|ion transport|ion transmembrane transporter activity|aminophospholipid transport|membrane|integral component of membrane|ion transmembrane transport|azurophil granule membrane|neutrophil degranulation|phospholipid translocation|recycling endosome|recycling endosome membrane ATP11C 1059.94908360577 1068.02550728992 1051.87265992163 0.984875972289013 -0.0219860408055539 0.976627662108706 1 5.8624 4.64967 6.63653 3.751 GeneID:286410,Genbank:XM_017029449.1,HGNC:HGNC:13554,MIM:300516 ATPase phospholipid transporting 11C GO:0000287,GO:0002329,GO:0004012,GO:0005524,GO:0005765,GO:0005783,GO:0005789,GO:0005886,GO:0016021,GO:0034220,GO:0045332,GO:0045579,GO:0055037 magnesium ion binding|pre-B cell differentiation|phospholipid-translocating ATPase activity|ATP binding|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of membrane|ion transmembrane transport|phospholipid translocation|positive regulation of B cell differentiation|recycling endosome ATP12A 1.74946347503013 1.07619535328461 2.42273159677566 2.25120057374467 1.17069460137475 0.729443551161772 1 0.0104769 0 0 0.00919709 GeneID:479,Genbank:NM_001185085.1,HGNC:HGNC:13816,MIM:182360 ATPase H+/K+ transporting non-gastric alpha2 subunit GO:0005391,GO:0005524,GO:0005886,GO:0005889,GO:0006885,GO:0008900,GO:0016323,GO:0034220,GO:0046872,GO:0055075 sodium:potassium-exchanging ATPase activity|ATP binding|plasma membrane|hydrogen:potassium-exchanging ATPase complex|regulation of pH|hydrogen:potassium-exchanging ATPase activity|basolateral plasma membrane|ion transmembrane transport|metal ion binding|potassium ion homeostasis hsa00190 Oxidative phosphorylation ATP13A1 1757.28023751272 1775.68047570951 1738.87999931593 0.979275282407509 -0.0302136244985882 0.809353803397272 1 16.3024 17.3755 17.5287 16.2696 GeneID:57130,Genbank:NM_020410.2,HGNC:HGNC:24215 ATPase 13A1 GO:0005388,GO:0005524,GO:0005789,GO:0005887,GO:0006874,GO:0015410,GO:0016020,GO:0034220,GO:0043231,GO:0046872 calcium-transporting ATPase activity|ATP binding|endoplasmic reticulum membrane|integral component of plasma membrane|cellular calcium ion homeostasis|manganese-transporting ATPase activity|membrane|ion transmembrane transport|intracellular membrane-bounded organelle|metal ion binding ATP13A2 1295.6809660892 1378.83460333366 1212.52732884475 0.879385624579759 -0.185432146049567 0.201553420629294 1 14.0405 13.9037 12.8051 12.647 GeneID:23400,Genbank:XM_006710512.1,HGNC:HGNC:30213,MIM:610513 ATPase cation transporting 13A2 GO:0005388,GO:0005524,GO:0005764,GO:0005765,GO:0005770,GO:0005771,GO:0005776,GO:0005887,GO:0006874,GO:0006879,GO:0006882,GO:0008270,GO:0010821,GO:0012506,GO:0016021,GO:0016241,GO:0016243,GO:0016887,GO:0019829,GO:0030003,GO:0030133,GO:0030145,GO:0031982,GO:0032585,GO:0033157,GO:0034220,GO:0034599,GO:0043005,GO:0043025,GO:0043202,GO:0046777,GO:0050714,GO:0052548,GO:0055069,GO:0070300,GO:0071287,GO:0071294,GO:0080025,GO:1901215,GO:1903135,GO:1903146,GO:1903543,GO:1904714,GO:1905037,GO:1905103,GO:1905122,GO:1905123,GO:1905165,GO:1905166,GO:1990938 calcium-transporting ATPase activity|ATP binding|lysosome|lysosomal membrane|late endosome|multivesicular body|autophagosome|integral component of plasma membrane|cellular calcium ion homeostasis|cellular iron ion homeostasis|cellular zinc ion homeostasis|zinc ion binding|regulation of mitochondrion organization|vesicle membrane|integral component of membrane|regulation of macroautophagy|regulation of autophagosome size|ATPase activity|cation-transporting ATPase activity|cellular cation homeostasis|transport vesicle|manganese ion binding|vesicle|multivesicular body membrane|regulation of intracellular protein transport|ion transmembrane transport|cellular response to oxidative stress|neuron projection|neuronal cell body|lysosomal lumen|protein autophosphorylation|positive regulation of protein secretion|regulation of endopeptidase activity|zinc ion homeostasis|phosphatidic acid binding|cellular response to manganese ion|cellular response to zinc ion|phosphatidylinositol-3,5-bisphosphate binding|negative regulation of neuron death|cupric ion binding|regulation of autophagy of mitochondrion|positive regulation of exosomal secretion|regulation of chaperone-mediated autophagy|autophagosome organization|integral component of lysosomal membrane|polyamine import|regulation of glucosylceramidase activity|regulation of lysosomal protein catabolic process|negative regulation of lysosomal protein catabolic process|peptidyl-aspartic acid autophosphorylation ATP13A3 1450.59015745909 1579.76453378359 1321.41578113459 0.836463759551401 -0.257625059164173 0.546582259202405 1 7.26275 5.65147 6.99118 3.97473 GeneID:79572,Genbank:XM_011513123.2,HGNC:HGNC:24113,MIM:610232 ATPase 13A3 GO:0005388,GO:0005524,GO:0005887,GO:0006874,GO:0016020,GO:0043231,GO:0046872 calcium-transporting ATPase activity|ATP binding|integral component of plasma membrane|cellular calcium ion homeostasis|membrane|intracellular membrane-bounded organelle|metal ion binding ATP13A4 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:84239,Genbank:NM_032279.3,HGNC:HGNC:25422,MIM:609556 ATPase 13A4 GO:0005388,GO:0005524,GO:0005886,GO:0005887,GO:0006874,GO:0019829,GO:0034220,GO:0043231,GO:0046872 calcium-transporting ATPase activity|ATP binding|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|cation-transporting ATPase activity|ion transmembrane transport|intracellular membrane-bounded organelle|metal ion binding ATP13A5 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00858425 0 0 GeneID:344905,Genbank:NM_198505.3,HGNC:HGNC:31789 ATPase 13A5 GO:0005388,GO:0005524,GO:0005886,GO:0005887,GO:0006874,GO:0019829,GO:0034220,GO:0043231,GO:0046872 calcium-transporting ATPase activity|ATP binding|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|cation-transporting ATPase activity|ion transmembrane transport|intracellular membrane-bounded organelle|metal ion binding ATP1A1 75351.2575798963 70144.5059864947 80558.0091732979 1.148457859106 0.199697920212406 0.121213299105608 1 342.967 366.325 417.693 402.581 GeneID:476,Genbank:NM_000701.7,HGNC:HGNC:799,MIM:182310 ATPase Na+/K+ transporting subunit alpha 1 GO:0002026,GO:0002028,GO:0005391,GO:0005524,GO:0005768,GO:0005783,GO:0005794,GO:0005886,GO:0005890,GO:0005901,GO:0006883,GO:0008217,GO:0010107,GO:0014069,GO:0014704,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0016791,GO:0019901,GO:0019904,GO:0030007,GO:0030315,GO:0030506,GO:0030955,GO:0031402,GO:0031947,GO:0034220,GO:0036376,GO:0042383,GO:0042470,GO:0042493,GO:0043209,GO:0043234,GO:0043531,GO:0043548,GO:0045822,GO:0045823,GO:0045989,GO:0051087,GO:0055119,GO:0060081,GO:0070062,GO:0071260,GO:0071383,GO:0086002,GO:0086004,GO:0086009,GO:0086013,GO:0086064,GO:1903416,GO:1903561,GO:1903779,GO:1990239,GO:1990573 regulation of the force of heart contraction|regulation of sodium ion transport|sodium:potassium-exchanging ATPase activity|ATP binding|endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|cellular sodium ion homeostasis|regulation of blood pressure|potassium ion import|postsynaptic density|intercalated disc|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|phosphatase activity|protein kinase binding|protein domain specific binding|cellular potassium ion homeostasis|T-tubule|ankyrin binding|potassium ion binding|sodium ion binding|negative regulation of glucocorticoid biosynthetic process|ion transmembrane transport|sodium ion export across plasma membrane|sarcolemma|melanosome|response to drug|myelin sheath|protein complex|ADP binding|phosphatidylinositol 3-kinase binding|negative regulation of heart contraction|positive regulation of heart contraction|positive regulation of striated muscle contraction|chaperone binding|relaxation of cardiac muscle|membrane hyperpolarization|extracellular exosome|cellular response to mechanical stimulus|cellular response to steroid hormone stimulus|cardiac muscle cell action potential involved in contraction|regulation of cardiac muscle cell contraction|membrane repolarization|membrane repolarization during cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|response to glycoside|extracellular vesicle|regulation of cardiac conduction|steroid hormone binding|potassium ion import across plasma membrane hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978 cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1A2 1.48835427179097 2.00831188251439 0.968396661067546 0.482194359102791 -1.05231332105607 0.812659389660536 1 0.0065746 0.0177364 0 0.0115191 GeneID:477,Genbank:NM_000702.3,HGNC:HGNC:800,MIM:182340 ATPase Na+/K+ transporting subunit alpha 2 GO:0001504,GO:0002026,GO:0002087,GO:0005391,GO:0005524,GO:0005737,GO:0005768,GO:0005886,GO:0005890,GO:0005901,GO:0006813,GO:0006814,GO:0006883,GO:0006940,GO:0006942,GO:0008217,GO:0008344,GO:0008542,GO:0010107,GO:0010881,GO:0014704,GO:0015991,GO:0016020,GO:0019229,GO:0030007,GO:0030315,GO:0034220,GO:0035094,GO:0036376,GO:0040011,GO:0043197,GO:0043209,GO:0045822,GO:0045988,GO:0046034,GO:0046872,GO:0051087,GO:0051481,GO:0051946,GO:0051966,GO:0055119,GO:0060048,GO:0071260,GO:0071383,GO:0086004,GO:0086009,GO:0086012,GO:0086064,GO:1903170,GO:1903280,GO:1903416,GO:1903561,GO:1903779,GO:1990239,GO:1990573 neurotransmitter uptake|regulation of the force of heart contraction|regulation of respiratory gaseous exchange by neurological system process|sodium:potassium-exchanging ATPase activity|ATP binding|cytoplasm|endosome|plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|potassium ion transport|sodium ion transport|cellular sodium ion homeostasis|regulation of smooth muscle contraction|regulation of striated muscle contraction|regulation of blood pressure|adult locomotory behavior|visual learning|potassium ion import|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|intercalated disc|ATP hydrolysis coupled proton transport|membrane|regulation of vasoconstriction|cellular potassium ion homeostasis|T-tubule|ion transmembrane transport|response to nicotine|sodium ion export across plasma membrane|locomotion|dendritic spine|myelin sheath|negative regulation of heart contraction|negative regulation of striated muscle contraction|ATP metabolic process|metal ion binding|chaperone binding|negative regulation of cytosolic calcium ion concentration|regulation of glutamate uptake involved in transmission of nerve impulse|regulation of synaptic transmission, glutamatergic|relaxation of cardiac muscle|cardiac muscle contraction|cellular response to mechanical stimulus|cellular response to steroid hormone stimulus|regulation of cardiac muscle cell contraction|membrane repolarization|membrane depolarization during cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|negative regulation of calcium ion transmembrane transport|negative regulation of calcium:sodium antiporter activity|response to glycoside|extracellular vesicle|regulation of cardiac conduction|steroid hormone binding|potassium ion import across plasma membrane hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978 cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1A3 29.4666160627904 37.1199480340658 21.8132840915149 0.587643174271051 -0.766987699982699 0.137268092715303 1 0.207846 0.34145 0.212722 0.0989683 GeneID:478,Genbank:NM_152296.4,HGNC:HGNC:801,MIM:182350 ATPase Na+/K+ transporting subunit alpha 3 GO:0001540,GO:0005391,GO:0005524,GO:0005634,GO:0005783,GO:0005794,GO:0005886,GO:0005890,GO:0006883,GO:0007613,GO:0008344,GO:0008542,GO:0010107,GO:0016020,GO:0016021,GO:0021987,GO:0030007,GO:0030424,GO:0031748,GO:0032809,GO:0034220,GO:0035235,GO:0036376,GO:0042383,GO:0042493,GO:0043025,GO:0043209,GO:0043395,GO:0044326,GO:0044327,GO:0045202,GO:0046872,GO:0051087,GO:0060048,GO:0060075,GO:0071300,GO:0071383,GO:0086037,GO:0086064,GO:0097067,GO:1903416,GO:1903561,GO:1903779,GO:1904646,GO:1990239,GO:1990535 amyloid-beta binding|sodium:potassium-exchanging ATPase activity|ATP binding|nucleus|endoplasmic reticulum|Golgi apparatus|plasma membrane|sodium:potassium-exchanging ATPase complex|cellular sodium ion homeostasis|memory|adult locomotory behavior|visual learning|potassium ion import|membrane|integral component of membrane|cerebral cortex development|cellular potassium ion homeostasis|axon|D1 dopamine receptor binding|neuronal cell body membrane|ion transmembrane transport|ionotropic glutamate receptor signaling pathway|sodium ion export across plasma membrane|sarcolemma|response to drug|neuronal cell body|myelin sheath|heparan sulfate proteoglycan binding|dendritic spine neck|dendritic spine head|synapse|metal ion binding|chaperone binding|cardiac muscle contraction|regulation of resting membrane potential|cellular response to retinoic acid|cellular response to steroid hormone stimulus|sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential|cell communication by electrical coupling involved in cardiac conduction|cellular response to thyroid hormone stimulus|response to glycoside|extracellular vesicle|regulation of cardiac conduction|cellular response to amyloid-beta|steroid hormone binding|neuron projection maintenance hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978 cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1A4 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:480,Genbank:NM_144699.3,HGNC:HGNC:14073,MIM:607321 ATPase Na+/K+ transporting subunit alpha 4 GO:0005391,GO:0005524,GO:0005886,GO:0005887,GO:0005890,GO:0006813,GO:0006814,GO:0007283,GO:0009566,GO:0015991,GO:0030317,GO:0030641,GO:0034220,GO:0042391,GO:0046872,GO:1903779 sodium:potassium-exchanging ATPase activity|ATP binding|plasma membrane|integral component of plasma membrane|sodium:potassium-exchanging ATPase complex|potassium ion transport|sodium ion transport|spermatogenesis|fertilization|ATP hydrolysis coupled proton transport|flagellated sperm motility|regulation of cellular pH|ion transmembrane transport|regulation of membrane potential|metal ion binding|regulation of cardiac conduction hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978 cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1B1 4020.24160711932 3887.73085125111 4152.75236298754 1.06816868807961 0.0951394993086486 0.569262157003754 1 77.0194 78.6635 96.5037 71.9954 GeneID:481,Genbank:NM_001677.3,HGNC:HGNC:804,MIM:182330 ATPase Na+/K+ transporting subunit beta 1 GO:0001666,GO:0001671,GO:0005391,GO:0005622,GO:0005886,GO:0005890,GO:0005901,GO:0006874,GO:0006883,GO:0007155,GO:0008022,GO:0010107,GO:0010468,GO:0010882,GO:0014704,GO:0016020,GO:0016323,GO:0016324,GO:0019901,GO:0023026,GO:0030007,GO:0032781,GO:0034220,GO:0036376,GO:0042383,GO:0043209,GO:0044861,GO:0046034,GO:0050821,GO:0050900,GO:0051117,GO:0055119,GO:0060048,GO:0070062,GO:0072659,GO:0086009,GO:0086013,GO:0086064,GO:1901018,GO:1903278,GO:1903281,GO:1903288,GO:1903561,GO:1903779,GO:1990573 response to hypoxia|ATPase activator activity|sodium:potassium-exchanging ATPase activity|intracellular|plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|cellular calcium ion homeostasis|cellular sodium ion homeostasis|cell adhesion|protein C-terminus binding|potassium ion import|regulation of gene expression|regulation of cardiac muscle contraction by calcium ion signaling|intercalated disc|membrane|basolateral plasma membrane|apical plasma membrane|protein kinase binding|MHC class II protein complex binding|cellular potassium ion homeostasis|positive regulation of ATPase activity|ion transmembrane transport|sodium ion export across plasma membrane|sarcolemma|myelin sheath|protein transport into plasma membrane raft|ATP metabolic process|protein stabilization|leukocyte migration|ATPase binding|relaxation of cardiac muscle|cardiac muscle contraction|extracellular exosome|protein localization to plasma membrane|membrane repolarization|membrane repolarization during cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|positive regulation of potassium ion transmembrane transporter activity|positive regulation of sodium ion export across plasma membrane|positive regulation of calcium:sodium antiporter activity|positive regulation of potassium ion import|extracellular vesicle|regulation of cardiac conduction|potassium ion import across plasma membrane hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978 cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1B2 15.2608012134946 17.4308480615094 13.0907543654798 0.751010755144305 -0.413094526319256 0.596697996649045 1 0.225364 0.209843 0.23459 0.0732622 GeneID:482,Genbank:NM_001303263.1,HGNC:HGNC:805,MIM:182331 ATPase Na+/K+ transporting subunit beta 2 GO:0001671,GO:0005391,GO:0005737,GO:0005886,GO:0005890,GO:0006810,GO:0006883,GO:0007155,GO:0010107,GO:0016324,GO:0030007,GO:0032781,GO:0034220,GO:0036376,GO:0050821,GO:0050900,GO:0051117,GO:0086009,GO:0086064,GO:1901018,GO:1903278,GO:1903288,GO:1903779 ATPase activator activity|sodium:potassium-exchanging ATPase activity|cytoplasm|plasma membrane|sodium:potassium-exchanging ATPase complex|transport|cellular sodium ion homeostasis|cell adhesion|potassium ion import|apical plasma membrane|cellular potassium ion homeostasis|positive regulation of ATPase activity|ion transmembrane transport|sodium ion export across plasma membrane|protein stabilization|leukocyte migration|ATPase binding|membrane repolarization|cell communication by electrical coupling involved in cardiac conduction|positive regulation of potassium ion transmembrane transporter activity|positive regulation of sodium ion export across plasma membrane|positive regulation of potassium ion import|regulation of cardiac conduction hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978 cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP1B3 3908.31781398931 3727.16398720104 4089.47164077759 1.09720732836567 0.13383616324624 0.318704853895311 1 86.4868 89.7868 105.534 90.8026 GeneID:483,Genbank:NM_001679.3,HGNC:HGNC:806,MIM:601867 ATPase Na+/K+ transporting subunit beta 3 GO:0001671,GO:0005391,GO:0005886,GO:0005890,GO:0005901,GO:0006810,GO:0006883,GO:0010107,GO:0030007,GO:0032781,GO:0034220,GO:0036376,GO:0042470,GO:0050821,GO:0050900,GO:0051117,GO:0070062,GO:0072659,GO:0086009,GO:1901018,GO:1903278,GO:1903288,GO:1903779 ATPase activator activity|sodium:potassium-exchanging ATPase activity|plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|transport|cellular sodium ion homeostasis|potassium ion import|cellular potassium ion homeostasis|positive regulation of ATPase activity|ion transmembrane transport|sodium ion export across plasma membrane|melanosome|protein stabilization|leukocyte migration|ATPase binding|extracellular exosome|protein localization to plasma membrane|membrane repolarization|positive regulation of potassium ion transmembrane transporter activity|positive regulation of sodium ion export across plasma membrane|positive regulation of potassium ion import|regulation of cardiac conduction hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04925,hsa04960,hsa04961,hsa04964,hsa04970,hsa04971,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978 cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone synthesis and secretion|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption ATP23 98.0172303153501 96.2156569162042 99.818803714496 1.03744865351208 0.053039934862821 0.885456997860877 1 1.77939 2.03334 1.79469 2.29886 GeneID:91419,Genbank:NM_001320408.1,HGNC:HGNC:29452 ATP23 metallopeptidase and ATP synthase assembly factor homolog GO:0004222,GO:0004677,GO:0005829,GO:0005886,GO:0005958,GO:0006303,GO:0030054,GO:0043231,GO:0046872 metalloendopeptidase activity|DNA-dependent protein kinase activity|cytosol|plasma membrane|DNA-dependent protein kinase-DNA ligase 4 complex|double-strand break repair via nonhomologous end joining|cell junction|intracellular membrane-bounded organelle|metal ion binding ATP2A1 11.7151304459758 11.7999312665537 11.6303296253979 0.985626895841631 -0.0208864699747652 1 1 0.0768351 0.0765685 0.0407851 0.0379878 GeneID:487,Genbank:NM_004320.4,HGNC:HGNC:811,MIM:108730 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 GO:0005388,GO:0005509,GO:0005524,GO:0005739,GO:0005789,GO:0005793,GO:0006816,GO:0006942,GO:0008637,GO:0016020,GO:0016021,GO:0016529,GO:0016887,GO:0031095,GO:0031448,GO:0031673,GO:0031674,GO:0032470,GO:0032471,GO:0033017,GO:0034220,GO:0034704,GO:0034976,GO:0042803,GO:0045988,GO:0048471,GO:0051561,GO:0051659,GO:0070059,GO:0070509,GO:0090076,GO:1903779 calcium-transporting ATPase activity|calcium ion binding|ATP binding|mitochondrion|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|calcium ion transport|regulation of striated muscle contraction|apoptotic mitochondrial changes|membrane|integral component of membrane|sarcoplasmic reticulum|ATPase activity|platelet dense tubular network membrane|positive regulation of fast-twitch skeletal muscle fiber contraction|H zone|I band|positive regulation of endoplasmic reticulum calcium ion concentration|negative regulation of endoplasmic reticulum calcium ion concentration|sarcoplasmic reticulum membrane|ion transmembrane transport|calcium channel complex|response to endoplasmic reticulum stress|protein homodimerization activity|negative regulation of striated muscle contraction|perinuclear region of cytoplasm|positive regulation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|calcium ion import|relaxation of skeletal muscle|regulation of cardiac conduction hsa04020,hsa04022,hsa04972,hsa05010 Calcium signaling pathway|cGMP-PKG signaling pathway|Pancreatic secretion|Alzheimer disease ATP2A2 6979.96258267774 7349.3596928364 6610.56547251908 0.899475022152278 -0.152844875575558 0.243171586110117 1 37.8808 38.3589 36.9052 32.63 GeneID:488,Genbank:NM_170665.3,HGNC:HGNC:812,MIM:108740 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 GO:0002026,GO:0005388,GO:0005509,GO:0005524,GO:0005654,GO:0005783,GO:0005789,GO:0005887,GO:0006874,GO:0006984,GO:0006996,GO:0007155,GO:0008022,GO:0008544,GO:0010460,GO:0010882,GO:0012506,GO:0014801,GO:0014883,GO:0014898,GO:0016020,GO:0016529,GO:0019899,GO:0031095,GO:0031234,GO:0031775,GO:0032469,GO:0032470,GO:0033017,GO:0033292,GO:0034220,GO:0034599,GO:0034976,GO:0043234,GO:0044548,GO:0045822,GO:0048471,GO:0055119,GO:0070296,GO:0070588,GO:0086036,GO:0086039,GO:0090534,GO:0097470,GO:0098909,GO:1903233,GO:1903515,GO:1903779,GO:1990036 regulation of the force of heart contraction|calcium-transporting ATPase activity|calcium ion binding|ATP binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|cellular calcium ion homeostasis|ER-nucleus signaling pathway|organelle organization|cell adhesion|protein C-terminus binding|epidermis development|positive regulation of heart rate|regulation of cardiac muscle contraction by calcium ion signaling|vesicle membrane|longitudinal sarcoplasmic reticulum|transition between fast and slow fiber|cardiac muscle hypertrophy in response to stress|membrane|sarcoplasmic reticulum|enzyme binding|platelet dense tubular network membrane|extrinsic component of cytoplasmic side of plasma membrane|lutropin-choriogonadotropic hormone receptor binding|endoplasmic reticulum calcium ion homeostasis|positive regulation of endoplasmic reticulum calcium ion concentration|sarcoplasmic reticulum membrane|T-tubule organization|ion transmembrane transport|cellular response to oxidative stress|response to endoplasmic reticulum stress|protein complex|S100 protein binding|negative regulation of heart contraction|perinuclear region of cytoplasm|relaxation of cardiac muscle|sarcoplasmic reticulum calcium ion transport|calcium ion transmembrane transport|regulation of cardiac muscle cell membrane potential|calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential|calcium ion-transporting ATPase complex|ribbon synapse|regulation of cardiac muscle cell action potential involved in regulation of contraction|regulation of calcium ion-dependent exocytosis of neurotransmitter|calcium ion transport from cytosol to endoplasmic reticulum|regulation of cardiac conduction|calcium ion import into sarcoplasmic reticulum hsa04020,hsa04022,hsa04024,hsa04260,hsa04261,hsa04919,hsa04972,hsa05010,hsa05410,hsa05412,hsa05414 Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Thyroid hormone signaling pathway|Pancreatic secretion|Alzheimer disease|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ATP2A3 23.5276054932068 18.9490885420664 28.1061224443472 1.48324402949263 0.568755975524205 0.342988992464901 1 0.0973973 0.10271 0.166464 0.161643 GeneID:489,Genbank:NM_174957.2,HGNC:HGNC:813,MIM:601929 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 GO:0005388,GO:0005524,GO:0005783,GO:0005789,GO:0006810,GO:0006816,GO:0016021,GO:0016529,GO:0031095,GO:0031965,GO:0033017,GO:0034220,GO:0046872,GO:1903779 calcium-transporting ATPase activity|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|transport|calcium ion transport|integral component of membrane|sarcoplasmic reticulum|platelet dense tubular network membrane|nuclear membrane|sarcoplasmic reticulum membrane|ion transmembrane transport|metal ion binding|regulation of cardiac conduction hsa04020,hsa04022,hsa04972,hsa05010 Calcium signaling pathway|cGMP-PKG signaling pathway|Pancreatic secretion|Alzheimer disease ATP2B1 488.561171824182 520.02221405226 457.100129596105 0.879001160419982 -0.186063024932735 0.619598404290173 1 3.00788 2.48698 3.16114 1.74543 GeneID:490,Genbank:XM_024448991.1,HGNC:HGNC:814,MIM:108731 ATPase plasma membrane Ca2+ transporting 1 GO:0003407,GO:0005388,GO:0005516,GO:0005524,GO:0005634,GO:0005886,GO:0005887,GO:0006810,GO:0007420,GO:0007568,GO:0009409,GO:0009898,GO:0015085,GO:0016020,GO:0016323,GO:0016324,GO:0030165,GO:0032591,GO:0032809,GO:0034220,GO:0043231,GO:0045121,GO:0046872,GO:0051480,GO:0070062,GO:0071305,GO:0071386,GO:1903779,GO:1990034 neural retina development|calcium-transporting ATPase activity|calmodulin binding|ATP binding|nucleus|plasma membrane|integral component of plasma membrane|transport|brain development|aging|response to cold|cytoplasmic side of plasma membrane|calcium ion transmembrane transporter activity|membrane|basolateral plasma membrane|apical plasma membrane|PDZ domain binding|dendritic spine membrane|neuronal cell body membrane|ion transmembrane transport|intracellular membrane-bounded organelle|membrane raft|metal ion binding|regulation of cytosolic calcium ion concentration|extracellular exosome|cellular response to vitamin D|cellular response to corticosterone stimulus|regulation of cardiac conduction|calcium ion export across plasma membrane hsa04020,hsa04022,hsa04024,hsa04261,hsa04925,hsa04961,hsa04970,hsa04972,hsa04978 Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Adrenergic signaling in cardiomyocytes|Aldosterone synthesis and secretion|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Pancreatic secretion|Mineral absorption ATP2B2 5.58515131602566 7.29323609956755 3.87706653248377 0.531597562392593 -0.911593605646075 0.519613084702997 1 0.0248491 0.0185997 0.0155405 0.0108909 GeneID:491,Genbank:XM_017006487.1,HGNC:HGNC:815,MIM:108733 ATPase plasma membrane Ca2+ transporting 2 GO:0005388,GO:0005509,GO:0005516,GO:0005524,GO:0005737,GO:0005886,GO:0005887,GO:0006816,GO:0007605,GO:0008022,GO:0030054,GO:0030165,GO:0030182,GO:0034220,GO:0043231,GO:0045202,GO:0046872,GO:0051480,GO:0070062,GO:1903779 calcium-transporting ATPase activity|calcium ion binding|calmodulin binding|ATP binding|cytoplasm|plasma membrane|integral component of plasma membrane|calcium ion transport|sensory perception of sound|protein C-terminus binding|cell junction|PDZ domain binding|neuron differentiation|ion transmembrane transport|intracellular membrane-bounded organelle|synapse|metal ion binding|regulation of cytosolic calcium ion concentration|extracellular exosome|regulation of cardiac conduction hsa04020,hsa04022,hsa04024,hsa04261,hsa04925,hsa04970,hsa04972 Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Adrenergic signaling in cardiomyocytes|Aldosterone synthesis and secretion|Salivary secretion|Pancreatic secretion ATP2B3 1.29221481755063 1.61429302992691 0.97013660517434 0.600966854957097 -0.734642670519382 0.974659005890232 1 0.00928866 0 0.00866803 0 GeneID:492,Genbank:XM_011531174.2,HGNC:HGNC:816,MIM:300014 ATPase plasma membrane Ca2+ transporting 3 GO:0005388,GO:0005516,GO:0005524,GO:0005794,GO:0005886,GO:0005887,GO:0006810,GO:0015085,GO:0030165,GO:0034220,GO:0043231,GO:0046872,GO:0051480,GO:1903561,GO:1903779,GO:1990034 calcium-transporting ATPase activity|calmodulin binding|ATP binding|Golgi apparatus|plasma membrane|integral component of plasma membrane|transport|calcium ion transmembrane transporter activity|PDZ domain binding|ion transmembrane transport|intracellular membrane-bounded organelle|metal ion binding|regulation of cytosolic calcium ion concentration|extracellular vesicle|regulation of cardiac conduction|calcium ion export across plasma membrane hsa04020,hsa04022,hsa04024,hsa04261,hsa04925,hsa04970,hsa04972 Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Adrenergic signaling in cardiomyocytes|Aldosterone synthesis and secretion|Salivary secretion|Pancreatic secretion ATP2B4 2290.31904962242 2157.2340140719 2423.40408517293 1.12338488516534 0.167852297094765 0.32658687457224 1 8.61887 8.39536 11.0585 8.345 GeneID:493,Genbank:NM_001001396.2,HGNC:HGNC:817,MIM:108732 ATPase plasma membrane Ca2+ transporting 4 GO:0003407,GO:0005388,GO:0005516,GO:0005524,GO:0005886,GO:0005887,GO:0005901,GO:0006357,GO:0006874,GO:0007283,GO:0010751,GO:0016020,GO:0016323,GO:0019901,GO:0021766,GO:0030018,GO:0030165,GO:0030315,GO:0030317,GO:0030346,GO:0033138,GO:0034220,GO:0036126,GO:0036487,GO:0043005,GO:0043231,GO:0043234,GO:0045019,GO:0046872,GO:0050998,GO:0051001,GO:0051599,GO:0070588,GO:0070885,GO:0071872,GO:0097110,GO:0097228,GO:0097553,GO:0098703,GO:0098736,GO:1900082,GO:1901205,GO:1901660,GO:1902083,GO:1902305,GO:1902806,GO:1903243,GO:1903249,GO:1903779,GO:2000481 neural retina development|calcium-transporting ATPase activity|calmodulin binding|ATP binding|plasma membrane|integral component of plasma membrane|caveola|regulation of transcription from RNA polymerase II promoter|cellular calcium ion homeostasis|spermatogenesis|negative regulation of nitric oxide mediated signal transduction|membrane|basolateral plasma membrane|protein kinase binding|hippocampus development|Z disc|PDZ domain binding|T-tubule|flagellated sperm motility|protein phosphatase 2B binding|positive regulation of peptidyl-serine phosphorylation|ion transmembrane transport|sperm flagellum|nitric-oxide synthase inhibitor activity|neuron projection|intracellular membrane-bounded organelle|protein complex|negative regulation of nitric oxide biosynthetic process|metal ion binding|nitric-oxide synthase binding|negative regulation of nitric-oxide synthase activity|response to hydrostatic pressure|calcium ion transmembrane transport|negative regulation of calcineurin-NFAT signaling cascade|cellular response to epinephrine stimulus|scaffold protein binding|sperm principal piece|calcium ion transmembrane import into cytosol|calcium ion import across plasma membrane|negative regulation of the force of heart contraction|negative regulation of arginine catabolic process|negative regulation of adrenergic receptor signaling pathway involved in heart process|calcium ion export|negative regulation of peptidyl-cysteine S-nitrosylation|regulation of sodium ion transmembrane transport|regulation of cell cycle G1/S phase transition|negative regulation of cardiac muscle hypertrophy in response to stress|negative regulation of citrulline biosynthetic process|regulation of cardiac conduction|positive regulation of cAMP-dependent protein kinase activity hsa04020,hsa04022,hsa04024,hsa04261,hsa04925,hsa04970,hsa04972 Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Adrenergic signaling in cardiomyocytes|Aldosterone synthesis and secretion|Salivary secretion|Pancreatic secretion ATP2C1 1364.11094423047 1371.13550572468 1357.08638273626 0.989753658241827 -0.0148586002575641 0.941401331377812 1 9.58831 9.25068 10.5556 8.12868 GeneID:27032,Genbank:XM_005247354.2,HGNC:HGNC:13211,MIM:604384 ATPase secretory pathway Ca2+ transporting 1 GO:0000139,GO:0004871,GO:0005388,GO:0005509,GO:0005524,GO:0005794,GO:0005802,GO:0006816,GO:0006828,GO:0006874,GO:0008544,GO:0015410,GO:0016020,GO:0016021,GO:0016339,GO:0030026,GO:0030145,GO:0031532,GO:0032468,GO:0032472,GO:0034220,GO:0043123,GO:0046872 Golgi membrane|signal transducer activity|calcium-transporting ATPase activity|calcium ion binding|ATP binding|Golgi apparatus|trans-Golgi network|calcium ion transport|manganese ion transport|cellular calcium ion homeostasis|epidermis development|manganese-transporting ATPase activity|membrane|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|cellular manganese ion homeostasis|manganese ion binding|actin cytoskeleton reorganization|Golgi calcium ion homeostasis|Golgi calcium ion transport|ion transmembrane transport|positive regulation of I-kappaB kinase/NF-kappaB signaling|metal ion binding ATP2C2 1.48585272210587 1.51824048055703 1.45346496365472 0.957335140426142 -0.0629040282857778 1 1 0.00724398 0 0.00680137 0 GeneID:9914,Genbank:NM_001286527.2,HGNC:HGNC:29103,MIM:613082 ATPase secretory pathway Ca2+ transporting 2 GO:0000139,GO:0005388,GO:0005524,GO:0016021,GO:0034220,GO:0046872 Golgi membrane|calcium-transporting ATPase activity|ATP binding|integral component of membrane|ion transmembrane transport|metal ion binding ATP5F1A 5999.27801654772 5935.47433928355 6063.08169381189 1.02149909969011 0.030687932535958 0.827035524398032 1 83.6389 90.0589 89.3021 89.2882 GeneID:498,Genbank:NM_001001937.1,HGNC:HGNC:823,MIM:164360 ATP synthase F1 subunit alpha GO:0001937,GO:0003723,GO:0005524,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0005886,GO:0006629,GO:0006754,GO:0016020,GO:0022857,GO:0031012,GO:0042288,GO:0042407,GO:0042776,GO:0043209,GO:0043532,GO:0043536,GO:0045259,GO:0045261,GO:0046933,GO:0070062 negative regulation of endothelial cell proliferation|RNA binding|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|plasma membrane|lipid metabolic process|ATP biosynthetic process|membrane|transmembrane transporter activity|extracellular matrix|MHC class I protein binding|cristae formation|mitochondrial ATP synthesis coupled proton transport|myelin sheath|angiostatin binding|positive regulation of blood vessel endothelial cell migration|proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, catalytic core F(1)|proton-transporting ATP synthase activity, rotational mechanism|extracellular exosome hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5F1B 25411.7609141423 24737.2759714274 26086.2458568573 1.05453186870648 0.0766026950652838 0.563267456128936 1 506.611 542.124 561.695 563.261 GeneID:506,Genbank:NM_001686.3,HGNC:HGNC:830,MIM:102910 ATP synthase F1 subunit beta GO:0001525,GO:0001649,GO:0005215,GO:0005524,GO:0005634,GO:0005739,GO:0005753,GO:0005754,GO:0005759,GO:0005886,GO:0006091,GO:0006629,GO:0006754,GO:0006933,GO:0007005,GO:0009986,GO:0015992,GO:0016020,GO:0022857,GO:0031012,GO:0031966,GO:0042288,GO:0042407,GO:0042645,GO:0042776,GO:0043209,GO:0043532,GO:0043536,GO:0045259,GO:0046933,GO:0046961,GO:0051453,GO:0070062 angiogenesis|osteoblast differentiation|transporter activity|ATP binding|nucleus|mitochondrion|mitochondrial proton-transporting ATP synthase complex|mitochondrial proton-transporting ATP synthase, catalytic core|mitochondrial matrix|plasma membrane|generation of precursor metabolites and energy|lipid metabolic process|ATP biosynthetic process|negative regulation of cell adhesion involved in substrate-bound cell migration|mitochondrion organization|cell surface|proton transport|membrane|transmembrane transporter activity|extracellular matrix|mitochondrial membrane|MHC class I protein binding|cristae formation|mitochondrial nucleoid|mitochondrial ATP synthesis coupled proton transport|myelin sheath|angiostatin binding|positive regulation of blood vessel endothelial cell migration|proton-transporting ATP synthase complex|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|regulation of intracellular pH|extracellular exosome hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5F1C 3794.60331444334 3758.42167872098 3830.78495016571 1.01925363294237 0.0275130990571171 0.833791851619729 1 104.962 107.415 108.122 113.155 GeneID:509,Genbank:NM_001001973.2,HGNC:HGNC:833,MIM:108729 ATP synthase F1 subunit gamma GO:0000275,GO:0003723,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0006119,GO:0006754,GO:0016020,GO:0022857,GO:0042407,GO:0042776,GO:0043209,GO:0046933,GO:0070062 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)|RNA binding|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|oxidative phosphorylation|ATP biosynthetic process|membrane|transmembrane transporter activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|myelin sheath|proton-transporting ATP synthase activity, rotational mechanism|extracellular exosome hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5F1D 1402.74244805848 1401.58961023265 1403.89528588432 1.00164504333853 0.00237134591747858 0.990587229288162 1 78.7638 82.0416 78.7266 84.8723 GeneID:513,Genbank:NM_001687.4,HGNC:HGNC:837,MIM:603150 ATP synthase F1 subunit delta GO:0000275,GO:0005215,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0006119,GO:0006754,GO:0015986,GO:0016887,GO:0022857,GO:0042407,GO:0042776,GO:0046688,GO:0046933 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)|transporter activity|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|oxidative phosphorylation|ATP biosynthetic process|ATP synthesis coupled proton transport|ATPase activity|transmembrane transporter activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|response to copper ion|proton-transporting ATP synthase activity, rotational mechanism hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5F1E 6462.51331734368 6563.46513224474 6361.56150244262 0.969238256662595 -0.0450767445676234 0.793800445969125 1 849.188 875.649 753.162 907.448 GeneID:514,Genbank:NM_006886.3,HGNC:HGNC:838,MIM:606153 ATP synthase F1 subunit epsilon GO:0000275,GO:0005753,GO:0005759,GO:0006754,GO:0022857,GO:0042407,GO:0042776,GO:0046933 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|ATP biosynthetic process|transmembrane transporter activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5IF1 1806.56051012008 1770.64345751928 1842.47756272088 1.04056949178365 0.0573733150049369 0.689801392501606 1 20.9639 21.8118 25.4983 24.4961 GeneID:93974,Genbank:NM_178191.2,HGNC:HGNC:871,MIM:614981 ATP synthase inhibitory factor subunit 1 GO:0001525,GO:0001937,GO:0004857,GO:0005516,GO:0005739,GO:0006091,GO:0006783,GO:0009986,GO:0019899,GO:0030218,GO:0032780,GO:0042030,GO:0042803,GO:0043532,GO:0051117,GO:0051260,GO:0051289,GO:0051346,GO:0051882,GO:0072593,GO:1901030,GO:1903052,GO:1903214,GO:1903578,GO:1904925 angiogenesis|negative regulation of endothelial cell proliferation|enzyme inhibitor activity|calmodulin binding|mitochondrion|generation of precursor metabolites and energy|heme biosynthetic process|cell surface|enzyme binding|erythrocyte differentiation|negative regulation of ATPase activity|ATPase inhibitor activity|protein homodimerization activity|angiostatin binding|ATPase binding|protein homooligomerization|protein homotetramerization|negative regulation of hydrolase activity|mitochondrial depolarization|reactive oxygen species metabolic process|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of proteolysis involved in cellular protein catabolic process|regulation of protein targeting to mitochondrion|regulation of ATP metabolic process|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization ATP5MC1 1772.43082483962 1846.89268247078 1697.96896720847 0.919365257832368 -0.121289946135283 0.493958485680003 1 117.592 122.852 107.22 123.05 GeneID:516,Genbank:NM_005175.2,HGNC:HGNC:841,MIM:603192 ATP synthase membrane subunit c locus 1 GO:0000276,GO:0005215,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0008289,GO:0015986,GO:0015991,GO:0016021,GO:0042407,GO:0042776,GO:0046933 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|transporter activity|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|lipid binding|ATP synthesis coupled proton transport|ATP hydrolysis coupled proton transport|integral component of membrane|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5MC2 2804.79810827866 2848.29216440814 2761.30405214918 0.969459554273981 -0.0447473843485192 0.731431811556949 1 35.5798 38.2809 35.0435 36.0745 GeneID:517,Genbank:NM_001002031.2,HGNC:HGNC:842,MIM:603193 ATP synthase membrane subunit c locus 2 GO:0000276,GO:0005215,GO:0005741,GO:0005753,GO:0006754,GO:0008289,GO:0015986,GO:0015991,GO:0016021,GO:0042407,GO:0042776,GO:0046933 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|transporter activity|mitochondrial outer membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|lipid binding|ATP synthesis coupled proton transport|ATP hydrolysis coupled proton transport|integral component of membrane|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5MC3 4958.57107509989 4956.85049855626 4960.29165164352 1.00069422168134 0.00100120268883475 0.988260013558752 1 27.2244 31.5551 28.7764 31.3752 GeneID:518,Genbank:NM_001689.4,HGNC:HGNC:843,MIM:602736 ATP synthase membrane subunit c locus 3 GO:0000276,GO:0005215,GO:0005741,GO:0005753,GO:0006754,GO:0008289,GO:0015986,GO:0015991,GO:0016021,GO:0042407,GO:0042776,GO:0046933 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|transporter activity|mitochondrial outer membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|lipid binding|ATP synthesis coupled proton transport|ATP hydrolysis coupled proton transport|integral component of membrane|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5MD 3085.32137619353 3108.66110666899 3061.98164571807 0.984984062479253 -0.0218277136362807 0.912605762097181 1 60.6258 60.9258 57.3465 72.7059 GeneID:84833,Genbank:NM_001206426.1,HGNC:HGNC:30889,MIM:615204 ATP synthase membrane subunit DAPIT GO:0005739,GO:0005753,GO:0016021,GO:0070062 mitochondrion|mitochondrial proton-transporting ATP synthase complex|integral component of membrane|extracellular exosome ATP5ME 2305.20604535765 2289.40042212208 2321.01166859322 1.01380765294078 0.0197839595687688 0.953628860263244 1 501.764 525.25 449.418 598.79 GeneID:521,Genbank:NM_007100.3,HGNC:HGNC:846,MIM:601519 ATP synthase membrane subunit e GO:0000276,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0015078,GO:0022857,GO:0042407,GO:0042776 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|hydrogen ion transmembrane transporter activity|transmembrane transporter activity|cristae formation|mitochondrial ATP synthesis coupled proton transport hsa00190,hsa04714 Oxidative phosphorylation|Thermogenesis ATP5MF 1499.94897826761 1461.91540194724 1537.98255458799 1.05203252701178 0.0731793109354737 0.805964484219892 1 354.76 374.228 334.526 418.171 GeneID:9551,Genbank:NM_001039178.2,HGNC:HGNC:848 ATP synthase membrane subunit f GO:0005753,GO:0006754,GO:0015992,GO:0016021,GO:0045263 mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|proton transport|integral component of membrane|proton-transporting ATP synthase complex, coupling factor F(o) hsa00190,hsa04714 Oxidative phosphorylation|Thermogenesis ATP5MG 4197.83332209406 4069.43370551942 4326.2329386687 1.06310441494623 0.0882833010338622 0.716580042094417 1 130.91 153.073 131.51 170.066 GeneID:10632,Genbank:NM_006476.4,HGNC:HGNC:14247,MIM:617473 ATP synthase membrane subunit g GO:0000276,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0015078,GO:0015986,GO:0022857,GO:0042407,GO:0042776,GO:0070062,GO:0099132 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|hydrogen ion transmembrane transporter activity|ATP synthesis coupled proton transport|transmembrane transporter activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|extracellular exosome|ATP hydrolysis coupled cation transmembrane transport hsa00190,hsa04714 Oxidative phosphorylation|Thermogenesis ATP5MGL 3.47948192606129 3.084507235799 3.87445661632358 1.25610229451122 0.328953959272994 0.933631849866183 1 0.199938 0.182964 0.0622995 0.408527 GeneID:267020,Genbank:NM_001165877.1,HGNC:HGNC:13213 ATP synthase membrane subunit g like GO:0000276,GO:0005739,GO:0015078,GO:0015986,GO:0099132 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|mitochondrion|hydrogen ion transmembrane transporter activity|ATP synthesis coupled proton transport|ATP hydrolysis coupled cation transmembrane transport ATP5MPL 1324.23385467001 1346.36542929063 1302.10228004939 0.967123970745031 -0.0482272615290778 0.732782473215996 1 38.6954 43.9916 35.3419 42.2807 GeneID:9556,Genbank:NM_004894.2,HGNC:HGNC:1188,MIM:604573 ATP synthase membrane subunit 6.8PL GO:0005753,GO:0016021 mitochondrial proton-transporting ATP synthase complex|integral component of membrane ATP5PB 3393.73540205201 3339.39914874406 3448.07165535996 1.03254253288553 0.0462012109126954 0.728377247763874 1 69.9926 70.8468 73.6242 73.8058 GeneID:515,Genbank:NM_001688.4,HGNC:HGNC:840,MIM:603270 ATP synthase peripheral stalk-membrane subunit b GO:0000276,GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0005753,GO:0005759,GO:0006754,GO:0015078,GO:0015986,GO:0016020,GO:0021762,GO:0022857,GO:0042407,GO:0042776,GO:0043209,GO:0070062,GO:0099132 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|mitochondrial matrix|ATP biosynthetic process|hydrogen ion transmembrane transporter activity|ATP synthesis coupled proton transport|membrane|substantia nigra development|transmembrane transporter activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|myelin sheath|extracellular exosome|ATP hydrolysis coupled cation transmembrane transport hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5PD 2658.01260071883 2646.05840553573 2669.96679590193 1.00903547341064 0.0129768943788662 0.955854019968214 1 158.451 163.883 146.903 181.764 GeneID:10476,Genbank:NM_001003785.1,HGNC:HGNC:845 ATP synthase peripheral stalk subunit d GO:0000274,GO:0005654,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0015078,GO:0015986,GO:0022857,GO:0042407,GO:0042776,GO:0043209,GO:0070062,GO:0099132 mitochondrial proton-transporting ATP synthase, stator stalk|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|hydrogen ion transmembrane transporter activity|ATP synthesis coupled proton transport|transmembrane transporter activity|cristae formation|mitochondrial ATP synthesis coupled proton transport|myelin sheath|extracellular exosome|ATP hydrolysis coupled cation transmembrane transport hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5PF 1888.71972084674 1845.31559005958 1932.1238516339 1.04704250158723 0.0663200053867961 0.643169604023133 1 33.6634 32.2373 34.0438 35.7263 GeneID:522,Genbank:NM_001003697.1,HGNC:HGNC:847,MIM:603152 ATP synthase peripheral stalk subunit F6 GO:0000276,GO:0005215,GO:0005739,GO:0005743,GO:0005753,GO:0006754,GO:0015078,GO:0021762,GO:0022857,GO:0042407,GO:0042776 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)|transporter activity|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|ATP biosynthetic process|hydrogen ion transmembrane transporter activity|substantia nigra development|transmembrane transporter activity|cristae formation|mitochondrial ATP synthesis coupled proton transport hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5PO 1944.36150100822 1895.59103070734 1993.1319713091 1.05145674305357 0.0723894987945774 0.624452630182197 1 100.558 108.394 104.757 118.901 GeneID:539,Genbank:NM_001697.2,HGNC:HGNC:850,MIM:600828 ATP synthase peripheral stalk subunit OSCP GO:0005215,GO:0005634,GO:0005739,GO:0005743,GO:0005753,GO:0005886,GO:0006754,GO:0008144,GO:0015992,GO:0016887,GO:0022857,GO:0031012,GO:0042407,GO:0042776,GO:0046933,GO:0070062 transporter activity|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial proton-transporting ATP synthase complex|plasma membrane|ATP biosynthetic process|drug binding|proton transport|ATPase activity|transmembrane transporter activity|extracellular matrix|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase activity, rotational mechanism|extracellular exosome hsa00190,hsa04714,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Alzheimer disease|Parkinson disease|Huntington disease ATP5S 227.71022942753 215.051033561601 240.36942529346 1.11773201603612 0.160574333548433 0.473943779477888 1 0.873495 0.909685 0.956211 0.898001 GeneID:27109,Genbank:XM_017021220.2,HGNC:HGNC:18799 ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) GO:0005743,GO:0006754,GO:0015078,GO:0015992,GO:0042407,GO:0042776,GO:0045263,GO:0046872 mitochondrial inner membrane|ATP biosynthetic process|hydrogen ion transmembrane transporter activity|proton transport|cristae formation|mitochondrial ATP synthesis coupled proton transport|proton-transporting ATP synthase complex, coupling factor F(o)|metal ion binding ATP6AP1 7847.34501649992 7567.20438633657 8127.48564666327 1.074040719891 0.103048690968744 0.448732172628319 1 134.728 142.069 150.255 154.076 GeneID:537,Genbank:NM_001183.5,HGNC:HGNC:868,MIM:300197 ATPase H+ transporting accessory protein 1 GO:0005215,GO:0005524,GO:0005789,GO:0006879,GO:0008286,GO:0010008,GO:0015991,GO:0015992,GO:0016021,GO:0016469,GO:0017137,GO:0033116,GO:0033180,GO:0033572,GO:0034220,GO:0036295,GO:0045669,GO:0045780,GO:0045851,GO:0045921,GO:0046933,GO:0046961,GO:0051656,GO:0070062,GO:0070374,GO:2001206 transporter activity|ATP binding|endoplasmic reticulum membrane|cellular iron ion homeostasis|insulin receptor signaling pathway|endosome membrane|ATP hydrolysis coupled proton transport|proton transport|integral component of membrane|proton-transporting two-sector ATPase complex|Rab GTPase binding|endoplasmic reticulum-Golgi intermediate compartment membrane|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|positive regulation of osteoblast differentiation|positive regulation of bone resorption|pH reduction|positive regulation of exocytosis|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|establishment of organelle localization|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|positive regulation of osteoclast development hsa00190,hsa04142,hsa04145,hsa05110,hsa05120,hsa05152,hsa05161,hsa05165,hsa05323 Oxidative phosphorylation|Lysosome|Phagosome|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Hepatitis B|Human papillomavirus infection|Rheumatoid arthritis ATP6AP1L 64.6741006672366 57.1452319294168 72.2029694050564 1.26349945511181 0.337425042115965 0.366271446337538 1 0.187951 0.283314 0.356038 0.367063 GeneID:92270,Genbank:XM_017010032.2,HGNC:HGNC:28091 ATPase H+ transporting accessory protein 1 like GO:0015991,GO:0016021,GO:0033180,GO:0046933,GO:0046961 ATP hydrolysis coupled proton transport|integral component of membrane|proton-transporting V-type ATPase, V1 domain|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism ATP6AP2 1805.64079922642 1917.54514024349 1693.73645820935 0.883283747883131 -0.1790511282427 0.214746507247724 1 46.1497 44.5 39.9806 40.1629 GeneID:10159,Genbank:NM_005765.2,HGNC:HGNC:18305,MIM:300556 ATPase H+ transporting accessory protein 2 GO:0002003,GO:0004872,GO:0005886,GO:0009897,GO:0016021,GO:0019899,GO:0021903,GO:0030177,GO:0032914,GO:0043005,GO:0043312,GO:0043408,GO:0044297,GO:0048069,GO:0060323,GO:0070062,GO:0070821,GO:0101003 angiotensin maturation|receptor activity|plasma membrane|external side of plasma membrane|integral component of membrane|enzyme binding|rostrocaudal neural tube patterning|positive regulation of Wnt signaling pathway|positive regulation of transforming growth factor beta1 production|neuron projection|neutrophil degranulation|regulation of MAPK cascade|cell body|eye pigmentation|head morphogenesis|extracellular exosome|tertiary granule membrane|ficolin-1-rich granule membrane hsa04614 Renin-angiotensin system ATP6V0A1 2115.35392685328 2088.69471238534 2142.01314132123 1.02552715273311 0.0363656903499954 0.806607470068041 1 14.5235 15.4999 15.6522 16.1527 GeneID:535,Genbank:NM_001130020.1,HGNC:HGNC:865,MIM:192130 ATPase H+ transporting V0 subunit a1 GO:0000220,GO:0005765,GO:0005794,GO:0005829,GO:0005886,GO:0007035,GO:0008286,GO:0010008,GO:0015986,GO:0015991,GO:0016021,GO:0016241,GO:0016471,GO:0016607,GO:0030667,GO:0030670,GO:0033572,GO:0034220,GO:0042470,GO:0043231,GO:0043312,GO:0046961,GO:0051117,GO:0070062,GO:0070072,GO:0090383,GO:0101003,GO:1901998 vacuolar proton-transporting V-type ATPase, V0 domain|lysosomal membrane|Golgi apparatus|cytosol|plasma membrane|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|ATP synthesis coupled proton transport|ATP hydrolysis coupled proton transport|integral component of membrane|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|nuclear speck|secretory granule membrane|phagocytic vesicle membrane|transferrin transport|ion transmembrane transport|melanosome|intracellular membrane-bounded organelle|neutrophil degranulation|proton-transporting ATPase activity, rotational mechanism|ATPase binding|extracellular exosome|vacuolar proton-transporting V-type ATPase complex assembly|phagosome acidification|ficolin-1-rich granule membrane|toxin transport hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323 Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0A2 707.247570911587 750.506609448818 663.988532374356 0.884720432858009 -0.176706451949089 0.273392674537798 1 4.48723 4.66544 4.60749 3.71166 GeneID:23545,Genbank:NM_012463.3,HGNC:HGNC:18481,MIM:611716 ATPase H+ transporting V0 subunit a2 GO:0000220,GO:0001669,GO:0005765,GO:0005886,GO:0006879,GO:0006955,GO:0007035,GO:0008286,GO:0010008,GO:0015986,GO:0015991,GO:0016021,GO:0016241,GO:0016471,GO:0030670,GO:0033572,GO:0034220,GO:0036295,GO:0046961,GO:0051117,GO:0070072,GO:0090383 vacuolar proton-transporting V-type ATPase, V0 domain|acrosomal vesicle|lysosomal membrane|plasma membrane|cellular iron ion homeostasis|immune response|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|ATP synthesis coupled proton transport|ATP hydrolysis coupled proton transport|integral component of membrane|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|proton-transporting ATPase activity, rotational mechanism|ATPase binding|vacuolar proton-transporting V-type ATPase complex assembly|phagosome acidification hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323 Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0A4 1.51236740913344 2.05633815719933 0.968396661067546 0.470932593298016 -1.08640751970762 0.811664485952849 1 0.0104128 0.0190134 0 0.00915535 GeneID:50617,Genbank:XM_005250394.3,HGNC:HGNC:866,MIM:605239 ATPase H+ transporting V0 subunit a4 GO:0000220,GO:0001503,GO:0005765,GO:0005768,GO:0005886,GO:0006885,GO:0007035,GO:0007588,GO:0007605,GO:0008286,GO:0010008,GO:0015986,GO:0015991,GO:0015992,GO:0016021,GO:0016324,GO:0016471,GO:0030670,GO:0031526,GO:0033572,GO:0034220,GO:0045177,GO:0046961,GO:0051117,GO:0070062,GO:0070072,GO:0090383 vacuolar proton-transporting V-type ATPase, V0 domain|ossification|lysosomal membrane|endosome|plasma membrane|regulation of pH|vacuolar acidification|excretion|sensory perception of sound|insulin receptor signaling pathway|endosome membrane|ATP synthesis coupled proton transport|ATP hydrolysis coupled proton transport|proton transport|integral component of membrane|apical plasma membrane|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|brush border membrane|transferrin transport|ion transmembrane transport|apical part of cell|proton-transporting ATPase activity, rotational mechanism|ATPase binding|extracellular exosome|vacuolar proton-transporting V-type ATPase complex assembly|phagosome acidification hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323 Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0B 4378.63605202151 4543.77646898773 4213.4956350553 0.927311381581671 -0.108874232593099 0.504853770678082 1 96.4519 108.387 90.4897 103.909 GeneID:533,Genbank:NM_001294333.1,HGNC:HGNC:861,MIM:603717 ATPase H+ transporting V0 subunit b GO:0000220,GO:0005768,GO:0005774,GO:0007035,GO:0015991,GO:0016021,GO:0046961 vacuolar proton-transporting V-type ATPase, V0 domain|endosome|vacuolar membrane|vacuolar acidification|ATP hydrolysis coupled proton transport|integral component of membrane|proton-transporting ATPase activity, rotational mechanism hsa00190,hsa04142,hsa04145,hsa04721,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323 Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0C 3849.5672739166 3713.58236012031 3985.55218771288 1.0732365142923 0.10196804477655 0.47280717068175 1 197.072 209.521 227.05 220.883 GeneID:527,Genbank:NM_001198569.1,HGNC:HGNC:855,MIM:108745 ATPase H+ transporting V0 subunit c GO:0000220,GO:0005765,GO:0005886,GO:0005925,GO:0007042,GO:0008286,GO:0010008,GO:0015991,GO:0015992,GO:0016021,GO:0016032,GO:0016241,GO:0030177,GO:0030670,GO:0031625,GO:0033572,GO:0034220,GO:0035577,GO:0043312,GO:0046933,GO:0046961,GO:0070062,GO:0070821,GO:0090383,GO:0101003 vacuolar proton-transporting V-type ATPase, V0 domain|lysosomal membrane|plasma membrane|focal adhesion|lysosomal lumen acidification|insulin receptor signaling pathway|endosome membrane|ATP hydrolysis coupled proton transport|proton transport|integral component of membrane|viral process|regulation of macroautophagy|positive regulation of Wnt signaling pathway|phagocytic vesicle membrane|ubiquitin protein ligase binding|transferrin transport|ion transmembrane transport|azurophil granule membrane|neutrophil degranulation|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|tertiary granule membrane|phagosome acidification|ficolin-1-rich granule membrane hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323 Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP6V0D1 2735.06220479027 2450.49557519369 3019.62883438685 1.23225231049363 0.301297686088943 0.0292096782292209 0.677045321871968 41.7271 42.668 53.0861 52.1439 GeneID:9114,Genbank:NM_004691.4,HGNC:HGNC:13724,MIM:607028 ATPase H+ transporting V0 subunit d1 GO:0005765,GO:0005769,GO:0005813,GO:0006879,GO:0007034,GO:0007035,GO:0008553,GO:0015991,GO:0016471,GO:0033179,GO:0036295,GO:0046961,GO:0060271 lysosomal membrane|early endosome|centrosome|cellular iron ion homeostasis|vacuolar transport|vacuolar acidification|hydrogen-exporting ATPase activity, phosphorylative mechanism|ATP hydrolysis coupled proton transport|vacuolar proton-transporting V-type ATPase complex|proton-transporting V-type ATPase, V0 domain|cellular response to increased oxygen levels|proton-transporting ATPase activity, rotational mechanism|cilium assembly hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05203,hsa05323 Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Viral carcinogenesis|Rheumatoid arthritis ATP6V0D2 3.02060169095008 3.13253351048394 2.90866987141623 0.928535915635542 -0.106970380410921 1 1 0.0586382 0.0369084 0.074724 0.0348927 GeneID:245972,Genbank:NM_152565.1,HGNC:HGNC:18266 ATPase H+ transporting V0 subunit d2 GO:0005765,GO:0005769,GO:0007034,GO:0007035,GO:0008286,GO:0008553,GO:0010008,GO:0015991,GO:0016020,GO:0016241,GO:0016324,GO:0016471,GO:0030670,GO:0033179,GO:0033572,GO:0034220,GO:0046961,GO:0070062,GO:0090383 lysosomal membrane|early endosome|vacuolar transport|vacuolar acidification|insulin receptor signaling pathway|hydrogen-exporting ATPase activity, phosphorylative mechanism|endosome membrane|ATP hydrolysis coupled proton transport|membrane|regulation of macroautophagy|apical plasma membrane|vacuolar proton-transporting V-type ATPase complex|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05203,hsa05323 Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Viral carcinogenesis|Rheumatoid arthritis ATP6V0E1 5113.58174219466 4840.20573023701 5386.95775415232 1.11296049267074 0.154402381503217 0.254892668550297 1 291.915 323.032 339.247 346.781 GeneID:8992,Genbank:NM_003945.3,HGNC:HGNC:863,MIM:603931 ATPase H+ transporting V0 subunit e1 GO:0005215,GO:0007035,GO:0008286,GO:0010008,GO:0015991,GO:0015992,GO:0016020,GO:0016021,GO:0016241,GO:0030670,GO:0033179,GO:0033572,GO:0034220,GO:0042625,GO:0046961,GO:0090383,GO:1902600 transporter activity|vacuolar acidification|insulin receptor signaling pathway|endosome membrane|ATP hydrolysis coupled proton transport|proton transport|membrane|integral component of membrane|regulation of macroautophagy|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|transferrin transport|ion transmembrane transport|ATPase coupled ion transmembrane transporter activity|proton-transporting ATPase activity, rotational mechanism|phagosome acidification|hydrogen ion transmembrane transport hsa00190,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V0E2 3323.77643476205 3216.99326146432 3430.55960805978 1.06638694247629 0.0927310203669532 0.511209418107913 1 63.2316 66.2904 69.087 71.8713 GeneID:155066,Genbank:NM_145230.3,HGNC:HGNC:21723,MIM:611019 ATPase H+ transporting V0 subunit e2 GO:0007035,GO:0008286,GO:0010008,GO:0015991,GO:0016020,GO:0016021,GO:0016241,GO:0030670,GO:0033179,GO:0033572,GO:0034220,GO:0042625,GO:0046961,GO:0090383,GO:1902600 vacuolar acidification|insulin receptor signaling pathway|endosome membrane|ATP hydrolysis coupled proton transport|membrane|integral component of membrane|regulation of macroautophagy|phagocytic vesicle membrane|proton-transporting V-type ATPase, V0 domain|transferrin transport|ion transmembrane transport|ATPase coupled ion transmembrane transporter activity|proton-transporting ATPase activity, rotational mechanism|phagosome acidification|hydrogen ion transmembrane transport hsa00190,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1A 1345.71365949649 1341.59695143829 1349.83036755468 1.00613702655448 0.00882680024125629 0.944079153847333 1 13.8021 12.7347 15.4547 11.6415 GeneID:523,Genbank:NM_001690.3,HGNC:HGNC:851,MIM:607027 ATPase H+ transporting V1 subunit A GO:0005524,GO:0005739,GO:0005765,GO:0005829,GO:0005886,GO:0005887,GO:0005902,GO:0006810,GO:0006879,GO:0008286,GO:0015991,GO:0016241,GO:0016324,GO:0016469,GO:0033180,GO:0033572,GO:0034220,GO:0036295,GO:0043209,GO:0046034,GO:0046961,GO:0070062,GO:0090383 ATP binding|mitochondrion|lysosomal membrane|cytosol|plasma membrane|integral component of plasma membrane|microvillus|transport|cellular iron ion homeostasis|insulin receptor signaling pathway|ATP hydrolysis coupled proton transport|regulation of macroautophagy|apical plasma membrane|proton-transporting two-sector ATPase complex|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|myelin sheath|ATP metabolic process|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1B1 7.74133562416526 7.24520982488261 8.23746142344792 1.13695277604764 0.185172332350861 0.914808144156951 1 0.142147 0.0624679 0.099167 0.123736 GeneID:525,Genbank:NM_001692.3,HGNC:HGNC:853,MIM:192132 ATPase H+ transporting V1 subunit B1 GO:0001503,GO:0005524,GO:0005737,GO:0005829,GO:0005902,GO:0006885,GO:0007588,GO:0007605,GO:0008286,GO:0015078,GO:0015991,GO:0015992,GO:0016241,GO:0016323,GO:0016324,GO:0016328,GO:0016471,GO:0016787,GO:0032403,GO:0033180,GO:0033572,GO:0034220,GO:0042472,GO:0045851,GO:0046034,GO:0055074,GO:0070062,GO:0090383,GO:0098850 ossification|ATP binding|cytoplasm|cytosol|microvillus|regulation of pH|excretion|sensory perception of sound|insulin receptor signaling pathway|hydrogen ion transmembrane transporter activity|ATP hydrolysis coupled proton transport|proton transport|regulation of macroautophagy|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|vacuolar proton-transporting V-type ATPase complex|hydrolase activity|protein complex binding|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|inner ear morphogenesis|pH reduction|ATP metabolic process|calcium ion homeostasis|extracellular exosome|phagosome acidification|extrinsic component of synaptic vesicle membrane hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1B2 5003.04003302086 4960.75617611254 5045.32388992919 1.01704734335138 0.0243868379255031 0.852228977687389 1 77.4027 77.6032 78.9646 80.0235 GeneID:526,Genbank:NM_001693.3,HGNC:HGNC:854,MIM:606939 ATPase H+ transporting V1 subunit B2 GO:0001726,GO:0005524,GO:0005765,GO:0005829,GO:0005886,GO:0005902,GO:0008286,GO:0012505,GO:0015078,GO:0015991,GO:0015992,GO:0016021,GO:0016241,GO:0033180,GO:0033572,GO:0034220,GO:0042470,GO:0043209,GO:0043231,GO:0046034,GO:0046961,GO:0070062,GO:0090383 ruffle|ATP binding|lysosomal membrane|cytosol|plasma membrane|microvillus|insulin receptor signaling pathway|endomembrane system|hydrogen ion transmembrane transporter activity|ATP hydrolysis coupled proton transport|proton transport|integral component of membrane|regulation of macroautophagy|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|melanosome|myelin sheath|intracellular membrane-bounded organelle|ATP metabolic process|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1C1 876.178943811224 909.006309685728 843.35157793672 0.927773073685587 -0.108156118740548 0.648951215231815 1 7.06462 6.04608 7.18856 5.24404 GeneID:528,Genbank:NM_001695.4,HGNC:HGNC:856,MIM:603097 ATPase H+ transporting V1 subunit C1 GO:0000221,GO:0005215,GO:0005765,GO:0005829,GO:0005886,GO:0008286,GO:0008553,GO:0015991,GO:0015992,GO:0016241,GO:0016469,GO:0031410,GO:0033572,GO:0034220,GO:0045177,GO:0046961,GO:0070062,GO:0090383 vacuolar proton-transporting V-type ATPase, V1 domain|transporter activity|lysosomal membrane|cytosol|plasma membrane|insulin receptor signaling pathway|hydrogen-exporting ATPase activity, phosphorylative mechanism|ATP hydrolysis coupled proton transport|proton transport|regulation of macroautophagy|proton-transporting two-sector ATPase complex|cytoplasmic vesicle|transferrin transport|ion transmembrane transport|apical part of cell|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1C2 231.813998326566 267.910084387241 195.717912265892 0.730535816572692 -0.452973087943336 0.395651630038695 1 2.02757 1.81353 0.77666 1.80067 GeneID:245973,Genbank:XM_017003745.2,HGNC:HGNC:18264 ATPase H+ transporting V1 subunit C2 GO:0000221,GO:0005765,GO:0005829,GO:0008286,GO:0008553,GO:0015991,GO:0016241,GO:0030177,GO:0033572,GO:0034220,GO:0046961,GO:0046983,GO:0070062,GO:0090383 vacuolar proton-transporting V-type ATPase, V1 domain|lysosomal membrane|cytosol|insulin receptor signaling pathway|hydrogen-exporting ATPase activity, phosphorylative mechanism|ATP hydrolysis coupled proton transport|regulation of macroautophagy|positive regulation of Wnt signaling pathway|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|protein dimerization activity|extracellular exosome|phagosome acidification hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1D 921.763044264756 929.512873328783 914.013215200729 0.983324966686532 -0.0242598214038295 0.89583657055223 1 21.5155 19.7716 20.9545 20.0726 GeneID:51382,Genbank:NM_015994.3,HGNC:HGNC:13527,MIM:609398 ATPase H+ transporting V1 subunit D GO:0005765,GO:0005829,GO:0005886,GO:0008286,GO:0015992,GO:0016020,GO:0016241,GO:0033176,GO:0033572,GO:0034220,GO:0035579,GO:0042626,GO:0043312,GO:0060271,GO:0061512,GO:0070062,GO:0090383 lysosomal membrane|cytosol|plasma membrane|insulin receptor signaling pathway|proton transport|membrane|regulation of macroautophagy|proton-transporting V-type ATPase complex|transferrin transport|ion transmembrane transport|specific granule membrane|ATPase activity, coupled to transmembrane movement of substances|neutrophil degranulation|cilium assembly|protein localization to cilium|extracellular exosome|phagosome acidification hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1E1 3119.00542343034 3269.39944150673 2968.61140535396 0.9079989944532 -0.139237395056397 0.30054019531405 1 78.0668 85.6364 69.8846 78.4705 GeneID:529,Genbank:NM_001039366.1,HGNC:HGNC:857,MIM:108746 ATPase H+ transporting V1 subunit E1 GO:0005739,GO:0005765,GO:0005768,GO:0005829,GO:0005902,GO:0008286,GO:0008553,GO:0015991,GO:0015992,GO:0016241,GO:0016324,GO:0016469,GO:0033178,GO:0033572,GO:0034220,GO:0046961,GO:0051117,GO:0070062,GO:0090383 mitochondrion|lysosomal membrane|endosome|cytosol|microvillus|insulin receptor signaling pathway|hydrogen-exporting ATPase activity, phosphorylative mechanism|ATP hydrolysis coupled proton transport|proton transport|regulation of macroautophagy|apical plasma membrane|proton-transporting two-sector ATPase complex|proton-transporting two-sector ATPase complex, catalytic domain|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|ATPase binding|extracellular exosome|phagosome acidification hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1E2 47.7421963543844 44.6052892323731 50.8791034763956 1.14065180053735 0.189858456566014 0.665680975004607 1 0.343293 0.404928 0.355226 0.542395 GeneID:90423,Genbank:NM_001318063.1,HGNC:HGNC:18125,MIM:617385 ATPase H+ transporting V1 subunit E2 GO:0001669,GO:0005829,GO:0008286,GO:0008553,GO:0015991,GO:0016241,GO:0033178,GO:0033572,GO:0034220,GO:0046961,GO:0090383 acrosomal vesicle|cytosol|insulin receptor signaling pathway|hydrogen-exporting ATPase activity, phosphorylative mechanism|ATP hydrolysis coupled proton transport|regulation of macroautophagy|proton-transporting two-sector ATPase complex, catalytic domain|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|phagosome acidification hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1F 3486.3137552685 3433.16851665389 3539.4589938831 1.03095987765052 0.0439881877584268 0.797147959700233 1 117.301 126.78 125.138 139.259 GeneID:9296,Genbank:NM_001198909.1,HGNC:HGNC:16832,MIM:607160 ATPase H+ transporting V1 subunit F GO:0005829,GO:0008286,GO:0015078,GO:0015991,GO:0015992,GO:0016020,GO:0016469,GO:0016471,GO:0033180,GO:0033572,GO:0034220,GO:0042624,GO:0042625,GO:0046961,GO:0070062,GO:0090383 cytosol|insulin receptor signaling pathway|hydrogen ion transmembrane transporter activity|ATP hydrolysis coupled proton transport|proton transport|membrane|proton-transporting two-sector ATPase complex|vacuolar proton-transporting V-type ATPase complex|proton-transporting V-type ATPase, V1 domain|transferrin transport|ion transmembrane transport|ATPase activity, uncoupled|ATPase coupled ion transmembrane transporter activity|proton-transporting ATPase activity, rotational mechanism|extracellular exosome|phagosome acidification hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1G1 2169.59852897876 2135.7002983511 2203.49675960643 1.03174437036305 0.0450855664074886 0.739058160888858 1 62.178 61.9791 62.6246 66.3019 GeneID:9550,Genbank:NM_004888.3,HGNC:HGNC:864,MIM:607296 ATPase H+ transporting V1 subunit G1 GO:0005765,GO:0005829,GO:0005886,GO:0006879,GO:0008286,GO:0008553,GO:0016241,GO:0016471,GO:0033572,GO:0034220,GO:0036295,GO:0051117,GO:0070062,GO:0090383 lysosomal membrane|cytosol|plasma membrane|cellular iron ion homeostasis|insulin receptor signaling pathway|hydrogen-exporting ATPase activity, phosphorylative mechanism|regulation of macroautophagy|vacuolar proton-transporting V-type ATPase complex|transferrin transport|ion transmembrane transport|cellular response to increased oxygen levels|ATPase binding|extracellular exosome|phagosome acidification hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1G2 18.4085253479908 17.4308480615094 19.3862026344723 1.11217782210383 0.153387473814467 0.857882267394119 1 0.364256 0.277667 0.602617 0.427759 GeneID:534,Genbank:NM_138282.2,HGNC:HGNC:862,MIM:606853 ATPase H+ transporting V1 subunit G2 GO:0005829,GO:0005886,GO:0015992,GO:0016471,GO:0042626 cytosol|plasma membrane|proton transport|vacuolar proton-transporting V-type ATPase complex|ATPase activity, coupled to transmembrane movement of substances hsa00190,hsa04145,hsa04150,hsa04721,hsa04966,hsa05110,hsa05120,hsa05165,hsa05323 Oxidative phosphorylation|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Human papillomavirus infection|Rheumatoid arthritis ATP6V1H 1158.23962299503 1129.64226776931 1186.83697822075 1.05063081657203 0.0712558066275557 0.644397511451347 1 16.0096 17.4004 18.4183 17.2821 GeneID:51606,Genbank:NM_213619.2,HGNC:HGNC:18303,MIM:608861 ATPase H+ transporting V1 subunit H GO:0000221,GO:0005765,GO:0005829,GO:0005886,GO:0006897,GO:0007035,GO:0008286,GO:0015991,GO:0016241,GO:0030234,GO:0033572,GO:0034220,GO:0046961,GO:0050690,GO:0070062,GO:0090383 vacuolar proton-transporting V-type ATPase, V1 domain|lysosomal membrane|cytosol|plasma membrane|endocytosis|vacuolar acidification|insulin receptor signaling pathway|ATP hydrolysis coupled proton transport|regulation of macroautophagy|enzyme regulator activity|transferrin transport|ion transmembrane transport|proton-transporting ATPase activity, rotational mechanism|regulation of defense response to virus by virus|extracellular exosome|phagosome acidification hsa00190,hsa04142,hsa04145,hsa04150,hsa04721,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323 Oxidative phosphorylation|Lysosome|Phagosome|mTOR signaling pathway|Synaptic vesicle cycle|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis ATP7A 283.293681953937 287.877533352799 278.709830555074 0.968154156766068 -0.046691312372211 0.893844020847329 1 1.4661 1.33648 1.65093 1.05837 GeneID:538,Genbank:NM_000052.6,HGNC:HGNC:869,MIM:300011 ATPase copper transporting alpha hsa01524,hsa04978 Platinum drug resistance|Mineral absorption ATP7B 105.660000725675 102.278810183324 109.041191268026 1.06611712702348 0.0923659458769498 0.757544410226611 1 0.301062 0.285246 0.298728 0.311419 GeneID:540,Genbank:XM_005266430.4,HGNC:HGNC:870,MIM:606882 ATPase copper transporting beta hsa01524 Platinum drug resistance ATP8A1 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.0056392 0.00544398 0 0 GeneID:10396,Genbank:XM_017007645.2,HGNC:HGNC:13531,MIM:609542 ATPase phospholipid transporting 8A1 GO:0000139,GO:0000287,GO:0004012,GO:0005524,GO:0005783,GO:0005802,GO:0005886,GO:0016021,GO:0042584,GO:0048194 Golgi membrane|magnesium ion binding|phospholipid-translocating ATPase activity|ATP binding|endoplasmic reticulum|trans-Golgi network|plasma membrane|integral component of membrane|chromaffin granule membrane|Golgi vesicle budding ATP8A2 11.4624946356615 15.1725961504623 7.75239312086075 0.510947041889368 -0.968754326939506 0.312461606110898 1 0.0384653 0.0120404 0.0122666 0.0114347 GeneID:51761,Genbank:NM_016529.5,HGNC:HGNC:13533,MIM:605870 ATPase phospholipid transporting 8A2 GO:0000287,GO:0001750,GO:0003011,GO:0004012,GO:0005524,GO:0005654,GO:0005768,GO:0005794,GO:0005886,GO:0007409,GO:0007568,GO:0008285,GO:0010842,GO:0010976,GO:0010996,GO:0016021,GO:0040018,GO:0042472,GO:0042755,GO:0043588,GO:0048666,GO:0050884,GO:0050908,GO:0060052,GO:0061092 magnesium ion binding|photoreceptor outer segment|involuntary skeletal muscle contraction|phospholipid-translocating ATPase activity|ATP binding|nucleoplasm|endosome|Golgi apparatus|plasma membrane|axonogenesis|aging|negative regulation of cell proliferation|retina layer formation|positive regulation of neuron projection development|response to auditory stimulus|integral component of membrane|positive regulation of multicellular organism growth|inner ear morphogenesis|eating behavior|skin development|neuron development|neuromuscular process controlling posture|detection of light stimulus involved in visual perception|neurofilament cytoskeleton organization|positive regulation of phospholipid translocation ATP8B1 60.1868498990461 74.3261399623936 46.0475598356987 0.619533852544974 -0.690744978680638 0.063085671952422 0.894697583479674 0.395591 0.41818 0.3091 0.195506 GeneID:5205,Genbank:XM_011526023.3,HGNC:HGNC:3706,MIM:602397 ATPase phospholipid transporting 8B1 GO:0000287,GO:0004012,GO:0005524,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006855,GO:0007030,GO:0007605,GO:0008206,GO:0015247,GO:0015721,GO:0016324,GO:0021650,GO:0031526,GO:0032420,GO:0032534,GO:0034220,GO:0045332,GO:0045892,GO:0060119,GO:1901612 magnesium ion binding|phospholipid-translocating ATPase activity|ATP binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|drug transmembrane transport|Golgi organization|sensory perception of sound|bile acid metabolic process|aminophospholipid transmembrane transporter activity|bile acid and bile salt transport|apical plasma membrane|vestibulocochlear nerve formation|brush border membrane|stereocilium|regulation of microvillus assembly|ion transmembrane transport|phospholipid translocation|negative regulation of transcription, DNA-templated|inner ear receptor cell development|cardiolipin binding ATP8B2 921.036560895082 936.788526119845 905.28459567032 0.966370285746332 -0.0493519999775491 0.737642398030756 1 5.41513 5.83656 5.67064 5.34384 GeneID:57198,Genbank:NM_001005855.1,HGNC:HGNC:13534,MIM:605867 ATPase phospholipid transporting 8B2 GO:0000287,GO:0004012,GO:0005524,GO:0005789,GO:0005794,GO:0005886,GO:0007030,GO:0016021,GO:0034220 magnesium ion binding|phospholipid-translocating ATPase activity|ATP binding|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|Golgi organization|integral component of membrane|ion transmembrane transport ATP8B3 210.639153929713 208.5360265121 212.742281347326 1.02017039887821 0.0288101454170143 0.914640115132545 1 0.581946 0.727 0.667627 0.772939 GeneID:148229,Genbank:XM_006722656.3,HGNC:HGNC:13535,MIM:605866 ATPase phospholipid transporting 8B3 GO:0000287,GO:0002080,GO:0004012,GO:0005524,GO:0005789,GO:0005794,GO:0005886,GO:0007030,GO:0007339,GO:0016021 magnesium ion binding|acrosomal membrane|phospholipid-translocating ATPase activity|ATP binding|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|Golgi organization|binding of sperm to zona pellucida|integral component of membrane ATP8B4 7.62102918352272 2.64246210852658 12.5995962585189 4.76812750421777 2.25342281533933 0.0450203483966487 0.789998430107923 0.00755255 0.00363077 0.0218614 0.0406503 GeneID:79895,Genbank:XM_011522056.3,HGNC:HGNC:13536,MIM:609123 ATPase phospholipid transporting 8B4 (putative) GO:0000287,GO:0004012,GO:0005524,GO:0005794,GO:0005886,GO:0007030,GO:0016021,GO:0035579,GO:0043312,GO:0070821 magnesium ion binding|phospholipid-translocating ATPase activity|ATP binding|Golgi apparatus|plasma membrane|Golgi organization|integral component of membrane|specific granule membrane|neutrophil degranulation|tertiary granule membrane ATP9A 2073.45954633421 1730.37034166366 2416.54875100476 1.39655002910035 0.481867256712849 0.000557362814642905 0.0663583556644534 9.47629 8.66147 14.2869 11.4262 GeneID:10079,Genbank:NM_006045.2,HGNC:HGNC:13540,MIM:609126 ATPase phospholipid transporting 9A (putative) GO:0000287,GO:0004012,GO:0005524,GO:0005769,GO:0005802,GO:0005886,GO:0006890,GO:0006897,GO:0016021,GO:0031901,GO:0045332,GO:0048471,GO:0055037 magnesium ion binding|phospholipid-translocating ATPase activity|ATP binding|early endosome|trans-Golgi network|plasma membrane|retrograde vesicle-mediated transport, Golgi to ER|endocytosis|integral component of membrane|early endosome membrane|phospholipid translocation|perinuclear region of cytoplasm|recycling endosome ATP9B 131.803372314479 135.180220698514 128.426523930445 0.9500393124588 -0.0739408817428362 0.80282135621357 1 0.28182 0.241603 0.2475 0.24438 GeneID:374868,Genbank:NM_198531.4,HGNC:HGNC:13541,MIM:614446 ATPase phospholipid transporting 9B (putative) GO:0000287,GO:0004012,GO:0005524,GO:0005768,GO:0005802,GO:0005886,GO:0006890,GO:0006897,GO:0016021,GO:0045332,GO:0048471 magnesium ion binding|phospholipid-translocating ATPase activity|ATP binding|endosome|trans-Golgi network|plasma membrane|retrograde vesicle-mediated transport, Golgi to ER|endocytosis|integral component of membrane|phospholipid translocation|perinuclear region of cytoplasm ATPAF1 986.2796808679 996.056722790507 976.502638945294 0.98036850372293 -0.0286039593695184 0.850327988403764 1 14.0216 15.3886 14.7296 14.9285 GeneID:64756,Genbank:NM_001042546.2,HGNC:HGNC:18803,MIM:608917 ATP synthase mitochondrial F1 complex assembly factor 1 GO:0005739,GO:0033615 mitochondrion|mitochondrial proton-transporting ATP synthase complex assembly ATPAF2 450.243467237806 428.497582748383 471.989351727229 1.10149828314057 0.139467246371967 0.460286449210402 1 3.86487 4.49724 4.29868 4.92648 GeneID:91647,Genbank:XM_017025303.1,HGNC:HGNC:18802,MIM:608918 ATP synthase mitochondrial F1 complex assembly factor 2 GO:0005739,GO:0005829,GO:0016607,GO:0043461 mitochondrion|cytosol|nuclear speck|proton-transporting ATP synthase complex assembly ATR 137.541072807232 141.281591585211 133.800554029253 0.947048745190235 -0.0784894108680772 0.91508669144925 1 0.641175 0.454698 0.744444 0.334254 GeneID:545,Genbank:NM_001354579.1,HGNC:HGNC:882,MIM:601215 ATR serine/threonine kinase hsa03460,hsa04110,hsa04115,hsa04218,hsa05165,hsa05166,hsa05170 Fanconi anemia pathway|Cell cycle|p53 signaling pathway|Cellular senescence|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection ATRAID 1792.98821656393 1709.0885999731 1876.88783315475 1.09818053504323 0.135115245237038 0.35004087127245 1 46.9925 49.581 52.5808 55.0439 GeneID:51374,Genbank:NM_080592.3,HGNC:HGNC:24090 all-trans retinoic acid induced differentiation factor GO:0005635,GO:0005765,GO:0005886,GO:0010468,GO:0016021,GO:0030154,GO:0030501,GO:0033689,GO:0045669,GO:0048471,GO:1903363 nuclear envelope|lysosomal membrane|plasma membrane|regulation of gene expression|integral component of membrane|cell differentiation|positive regulation of bone mineralization|negative regulation of osteoblast proliferation|positive regulation of osteoblast differentiation|perinuclear region of cytoplasm|negative regulation of cellular protein catabolic process ATRIP 526.220925751376 514.027721370895 538.414130131856 1.04744181635948 0.0668701068544688 0.71456643232111 1 5.11575 5.50267 5.70014 5.57889 GeneID:84126,Genbank:NM_130384.2,HGNC:HGNC:33499,MIM:606605 ATR interacting protein GO:0000077,GO:0005634,GO:0005654,GO:0006260,GO:0036297,GO:0070530,GO:1901796 DNA damage checkpoint|nucleus|nucleoplasm|DNA replication|interstrand cross-link repair|K63-linked polyubiquitin modification-dependent protein binding|regulation of signal transduction by p53 class mediator hsa03460 Fanconi anemia pathway ATRN 1502.08150038757 1518.21374424083 1485.9492565343 0.978748389132349 -0.0309900669334255 0.823305468502139 1 5.92311 6.28699 6.57267 5.64812 GeneID:8455,Genbank:NM_139321.2,HGNC:HGNC:885,MIM:603130 attractin ATRNL1 217.200957943142 192.545966691139 241.855949195144 1.25609460094847 0.328945122812088 0.179076689064326 1 0.292573 0.263272 0.418158 0.310416 GeneID:26033,Genbank:NM_207303.4,HGNC:HGNC:29063,MIM:612869 attractin like 1 GO:0007186,GO:0016021,GO:0030246 G-protein coupled receptor signaling pathway|integral component of membrane|carbohydrate binding ATRX 160.962896338511 143.539843496258 178.385949180763 1.24276260051387 0.313550731006703 0.480332524819078 1 0.406159 0.350361 0.58838 0.339271 GeneID:546,Genbank:NM_138270.3,HGNC:HGNC:886,MIM:300504 ATRX, chromatin remodeler GO:0000212,GO:0000780,GO:0000784,GO:0003677,GO:0003678,GO:0003682,GO:0004386,GO:0005524,GO:0005634,GO:0005654,GO:0005720,GO:0005721,GO:0006281,GO:0006306,GO:0006310,GO:0006334,GO:0006336,GO:0006338,GO:0006351,GO:0006355,GO:0007283,GO:0010571,GO:0015616,GO:0016569,GO:0016604,GO:0016605,GO:0030330,GO:0030900,GO:0031297,GO:0031618,GO:0031933,GO:0032206,GO:0035064,GO:0035128,GO:0035264,GO:0042393,GO:0045944,GO:0046872,GO:0060009,GO:0070087,GO:0070192,GO:0070198,GO:0070603,GO:0072520,GO:0072711,GO:1900112,GO:1901581,GO:1901582,GO:1904908,GO:1990707 meiotic spindle organization|condensed nuclear chromosome, centromeric region|nuclear chromosome, telomeric region|DNA binding|DNA helicase activity|chromatin binding|helicase activity|ATP binding|nucleus|nucleoplasm|nuclear heterochromatin|pericentric heterochromatin|DNA repair|DNA methylation|DNA recombination|nucleosome assembly|DNA replication-independent nucleosome assembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|spermatogenesis|positive regulation of nuclear cell cycle DNA replication|DNA translocase activity|covalent chromatin modification|nuclear body|PML body|DNA damage response, signal transduction by p53 class mediator|forebrain development|replication fork processing|nuclear pericentric heterochromatin|telomeric heterochromatin|positive regulation of telomere maintenance|methylated histone binding|post-embryonic forelimb morphogenesis|multicellular organism growth|histone binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|Sertoli cell development|chromo shadow domain binding|chromosome organization involved in meiotic cell cycle|protein localization to chromosome, telomeric region|SWI/SNF superfamily-type complex|seminiferous tubule development|cellular response to hydroxyurea|regulation of histone H3-K9 trimethylation|negative regulation of telomeric RNA transcription from RNA pol II promoter|positive regulation of telomeric RNA transcription from RNA pol II promoter|negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric|nuclear subtelomeric heterochromatin ATXN1 910.542082250264 812.925939939326 1008.1582245612 1.24015998878871 0.310526249759809 0.17442367935717 1 3.36377 2.97837 4.72888 3.32004 GeneID:6310,Genbank:NM_001128164.1,HGNC:HGNC:10548,MIM:601556 ataxin 1 ATXN10 2260.90483197259 2404.39842044352 2117.41124350166 0.880640756331508 -0.183374480686694 0.191569072693963 1 32.4103 32.0378 30.4055 26.8855 GeneID:25814,Genbank:NM_013236.3,HGNC:HGNC:10549,MIM:611150 ataxin 10 GO:0005615,GO:0005737,GO:0005829,GO:0005886,GO:0007399,GO:0016020,GO:0019899,GO:0030425,GO:0031175,GO:0042802,GO:0043025,GO:0048471,GO:0060271,GO:0070207 extracellular space|cytoplasm|cytosol|plasma membrane|nervous system development|membrane|enzyme binding|dendrite|neuron projection development|identical protein binding|neuronal cell body|perinuclear region of cytoplasm|cilium assembly|protein homotrimerization ATXN1L 1860.38687676388 1827.26919208142 1893.50456144635 1.03624828221915 0.0513697101784821 0.715714923562074 1 9.65922 9.52673 10.6519 9.56286 GeneID:342371,Genbank:NM_001137675.3,HGNC:HGNC:33279,MIM:614301 ataxin 1 like GO:0000122,GO:0003677,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0007420,GO:0007612,GO:0007613,GO:0030198,GO:0030425,GO:0035176,GO:0048286,GO:1902035 negative regulation of transcription from RNA polymerase II promoter|DNA binding|RNA binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|brain development|learning|memory|extracellular matrix organization|dendrite|social behavior|lung alveolus development|positive regulation of hematopoietic stem cell proliferation ATXN2 644.069869831366 662.920132669107 625.219606993625 0.943129611219244 -0.0844720454992032 0.603250278423133 1 4.38715 4.50539 4.66509 3.82244 GeneID:6311,Genbank:NM_002973.3,HGNC:HGNC:10555,MIM:601517 ataxin 2 GO:0002091,GO:0003723,GO:0005154,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0005844,GO:0006417,GO:0008022,GO:0010494,GO:0010603,GO:0016020,GO:0016070,GO:0030529,GO:0033962,GO:0034063,GO:0048471,GO:0050658 negative regulation of receptor internalization|RNA binding|epidermal growth factor receptor binding|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|polysome|regulation of translation|protein C-terminus binding|cytoplasmic stress granule|regulation of cytoplasmic mRNA processing body assembly|membrane|RNA metabolic process|intracellular ribonucleoprotein complex|cytoplasmic mRNA processing body assembly|stress granule assembly|perinuclear region of cytoplasm|RNA transport ATXN2L 3527.67963305296 3448.71551434673 3606.64375175919 1.0457933502359 0.0645978018300072 0.649251979171331 1 21.9421 22.9809 24.4891 23.3258 GeneID:11273,Genbank:XM_005255069.1,HGNC:HGNC:31326,MIM:607931 ataxin 2 like GO:0003723,GO:0005829,GO:0010494,GO:0010603,GO:0016020,GO:0016607,GO:0034063,GO:0045296 RNA binding|cytosol|cytoplasmic stress granule|regulation of cytoplasmic mRNA processing body assembly|membrane|nuclear speck|stress granule assembly|cadherin binding ATXN3 72.0352913647581 83.9638718672701 60.106710862246 0.715863972510255 -0.482242620287376 0.166463519920089 1 0.543645 0.468419 0.518313 0.285388 GeneID:4287,Genbank:NM_001164782.1,HGNC:HGNC:7106,MIM:607047 ataxin 3 GO:0005829,GO:0016020,GO:0042803,GO:0070062 cytosol|membrane|protein homodimerization activity|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum ATXN7 400.388972461968 393.625060969402 407.152883954534 1.03436728076159 0.0487485454681025 0.849466853142408 1 2.20423 1.82429 2.52048 1.69566 GeneID:6314,Genbank:NM_000333.3,HGNC:HGNC:10560,MIM:607640 ataxin 7 GO:0000226,GO:0003682,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006351,GO:0006997,GO:0007601,GO:0015630,GO:0016363,GO:0016578,GO:0016579,GO:0036459,GO:0042326,GO:0043569,GO:0045944 microtubule cytoskeleton organization|chromatin binding|nucleus|nucleoplasm|nucleolus|cytosol|transcription, DNA-templated|nucleus organization|visual perception|microtubule cytoskeleton|nuclear matrix|histone deubiquitination|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|negative regulation of phosphorylation|negative regulation of insulin-like growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter ATXN7L1 109.691826500785 106.929584174365 112.454068827204 1.05166469780552 0.0726748035653998 0.81195919587924 1 0.222705 0.195142 0.257781 0.179382 GeneID:222255,Genbank:NM_020725.1,HGNC:HGNC:22210 ataxin 7 like 1 ATXN7L2 197.924043254892 225.256289108444 170.591797401339 0.75732312769839 -0.40101910740778 0.077999999881072 0.94157495521624 1.32659 1.63595 1.18943 1.13629 GeneID:127002,Genbank:NM_001350177.1,HGNC:HGNC:28713 ataxin 7 like 2 ATXN7L3 2640.25662945361 2679.56759131417 2600.94566759306 0.970658727185699 -0.0429639456275392 0.73371545858401 1 18.0428 19.9747 18.3772 18.8056 GeneID:56970,Genbank:XM_017024881.1,HGNC:HGNC:25416 ataxin 7 like 3 GO:0000124,GO:0003713,GO:0005634,GO:0006351,GO:0010390,GO:0016578,GO:0030374,GO:0045893,GO:0046872,GO:0071819 SAGA complex|transcription coactivator activity|nucleus|transcription, DNA-templated|histone monoubiquitination|histone deubiquitination|ligand-dependent nuclear receptor transcription coactivator activity|positive regulation of transcription, DNA-templated|metal ion binding|DUBm complex ATXN7L3B 1265.48473271785 1274.8738565355 1256.0956089002 0.985270505360954 -0.0214082249726488 0.876143197127133 1 15.761 17.2232 15.8572 16.8658 GeneID:552889,Genbank:NM_001136262.1,HGNC:HGNC:37931,MIM:615579 ataxin 7 like 3B GO:0005737,GO:0010468 cytoplasm|regulation of gene expression AUH 219.833228319003 223.516517563823 216.149939074184 0.967042352977177 -0.0483490189473069 0.833235461937117 1 0.614062 0.702482 0.697801 0.61769 GeneID:549,Genbank:NM_001306190.1,HGNC:HGNC:890,MIM:600529 AU RNA binding methylglutaconyl-CoA hydratase GO:0003730,GO:0004300,GO:0004490,GO:0005739,GO:0005759,GO:0006552,GO:0006635,GO:0009083,GO:0050011 mRNA 3'-UTR binding|enoyl-CoA hydratase activity|methylglutaconyl-CoA hydratase activity|mitochondrion|mitochondrial matrix|leucine catabolic process|fatty acid beta-oxidation|branched-chain amino acid catabolic process|itaconyl-CoA hydratase activity hsa00280 Valine, leucine and isoleucine degradation AUNIP 313.682278103527 348.713013779558 278.651542427497 0.799085584467602 -0.323578066484268 0.100745492060263 1 4.96145 5.23657 4.06836 4.06056 GeneID:79000,Genbank:NM_001287490.1,HGNC:HGNC:28363 aurora kinase A and ninein interacting protein GO:0000724,GO:0000922,GO:0003684,GO:0005634,GO:0005737,GO:0005813,GO:0007051,GO:0090734,GO:2001033 double-strand break repair via homologous recombination|spindle pole|damaged DNA binding|nucleus|cytoplasm|centrosome|spindle organization|site of DNA damage|negative regulation of double-strand break repair via nonhomologous end joining AUP1 2201.34714465067 2023.22909227861 2379.46519702274 1.17607304388003 0.233977666272011 0.0985902681996863 1 48.5749 51.4937 60.5583 61.1065 GeneID:550,Genbank:NM_181575.4,HGNC:HGNC:891,MIM:602434 AUP1, lipid droplet regulating VLDL assembly factor GO:0000839,GO:0016020,GO:0030176,GO:0030433,GO:0030970,GO:0043130,GO:0070062,GO:0097027 Hrd1p ubiquitin ligase ERAD-L complex|membrane|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|ubiquitin binding|extracellular exosome|ubiquitin-protein transferase activator activity AURKA 3588.13888002255 3734.99532097725 3441.28243906785 0.921361914361768 -0.11816013130276 0.382509689039784 1 45.5691 46.028 42.2825 42.5639 GeneID:6790,Genbank:NM_198437.2,HGNC:HGNC:11393,MIM:603072 aurora kinase A hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation AURKAIP1 2812.77284508427 2792.01343942476 2833.53225074379 1.01487056284643 0.0212957370189068 0.904189894534688 1 80.055 83.5007 83.349 85.6736 GeneID:54998,Genbank:XM_024447924.1,HGNC:HGNC:24114,MIM:609183 aurora kinase A interacting protein 1 GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0005840,GO:0006397,GO:0043231,GO:0045839,GO:0045862,GO:0070125,GO:0070126 nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|ribosome|mRNA processing|intracellular membrane-bounded organelle|negative regulation of mitotic nuclear division|positive regulation of proteolysis|mitochondrial translational elongation|mitochondrial translational termination AURKB 2521.73725115083 2462.42098497493 2581.05351732672 1.04817719353256 0.0678826239573636 0.63860610667028 1 21.3628 20.8031 22.2426 23.4816 GeneID:9212,Genbank:NM_001313955.1,HGNC:HGNC:11390,MIM:604970 aurora kinase B GO:0000122,GO:0000779,GO:0000780,GO:0002903,GO:0004674,GO:0004712,GO:0005524,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005876,GO:0006468,GO:0007051,GO:0007062,GO:0007568,GO:0008283,GO:0008608,GO:0009838,GO:0010369,GO:0016570,GO:0016925,GO:0019900,GO:0030496,GO:0031145,GO:0031577,GO:0031616,GO:0032091,GO:0032133,GO:0032212,GO:0032466,GO:0032467,GO:0034501,GO:0034644,GO:0035174,GO:0036089,GO:0042787,GO:0043988,GO:0044878,GO:0046777,GO:0046872,GO:0051233,GO:0051256,GO:0051973,GO:0051983,GO:1901796,GO:1904355,GO:1990023 negative regulation of transcription from RNA polymerase II promoter|condensed chromosome, centromeric region|condensed nuclear chromosome, centromeric region|negative regulation of B cell apoptotic process|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|spindle|cytosol|spindle microtubule|protein phosphorylation|spindle organization|sister chromatid cohesion|aging|cell proliferation|attachment of spindle microtubules to kinetochore|abscission|chromocenter|histone modification|protein sumoylation|kinase binding|midbody|anaphase-promoting complex-dependent catabolic process|spindle checkpoint|spindle pole centrosome|negative regulation of protein binding|chromosome passenger complex|positive regulation of telomere maintenance via telomerase|negative regulation of cytokinesis|positive regulation of cytokinesis|protein localization to kinetochore|cellular response to UV|histone serine kinase activity|cleavage furrow formation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|histone H3-S28 phosphorylation|mitotic cytokinesis checkpoint|protein autophosphorylation|metal ion binding|spindle midzone|mitotic spindle midzone assembly|positive regulation of telomerase activity|regulation of chromosome segregation|regulation of signal transduction by p53 class mediator|positive regulation of telomere capping|mitotic spindle midzone AURKC 16.9311331126151 13.5102768458505 20.3519893793796 1.50640801899115 0.59111258491606 0.393378722622094 1 0.437676 0.242209 0.441833 0.410285 GeneID:6795,Genbank:NM_003160.2,HGNC:HGNC:11391,MIM:603495 aurora kinase C GO:0000780,GO:0000793,GO:0000910,GO:0004672,GO:0004712,GO:0005524,GO:0005737,GO:0005819,GO:0005876,GO:0006468,GO:0007283,GO:0008608,GO:0016570,GO:0030496,GO:0031616,GO:0032133,GO:0032467,GO:0035174,GO:0048599,GO:0051233,GO:0051256,GO:0051321 condensed nuclear chromosome, centromeric region|condensed chromosome|cytokinesis|protein kinase activity|protein serine/threonine/tyrosine kinase activity|ATP binding|cytoplasm|spindle|spindle microtubule|protein phosphorylation|spermatogenesis|attachment of spindle microtubules to kinetochore|histone modification|midbody|spindle pole centrosome|chromosome passenger complex|positive regulation of cytokinesis|histone serine kinase activity|oocyte development|spindle midzone|mitotic spindle midzone assembly|meiotic cell cycle AUTS2 2190.0238560176 2139.39258085015 2240.65513118505 1.04733238361267 0.0667193716761505 0.68005757953496 1 4.27978 4.60427 5.34054 4.1546 GeneID:26053,Genbank:XM_017011951.2,HGNC:HGNC:14262,MIM:607270 AUTS2, activator of transcription and developmental regulator GO:0001764,GO:0003682,GO:0005634,GO:0005737,GO:0006351,GO:0010592,GO:0015629,GO:0030426,GO:0031532,GO:0035022,GO:0045944,GO:0048675,GO:0051571,GO:0060013,GO:0097484,GO:0098582,GO:2000620 neuron migration|chromatin binding|nucleus|cytoplasm|transcription, DNA-templated|positive regulation of lamellipodium assembly|actin cytoskeleton|growth cone|actin cytoskeleton reorganization|positive regulation of Rac protein signal transduction|positive regulation of transcription from RNA polymerase II promoter|axon extension|positive regulation of histone H3-K4 methylation|righting reflex|dendrite extension|innate vocalization behavior|positive regulation of histone H4-K16 acetylation AVEN 532.890014512135 523.00289408529 542.77713493898 1.03780904671335 0.0535410172001353 0.782180561368251 1 5.58538 6.3355 6.55268 6.38905 GeneID:57099,Genbank:XM_011521818.2,HGNC:HGNC:13509,MIM:605265 apoptosis and caspase activation inhibitor GO:0005622,GO:0006915,GO:0012505,GO:0016020,GO:0043066 intracellular|apoptotic process|endomembrane system|membrane|negative regulation of apoptotic process AVIL 4.02138611046879 4.65077399104097 3.3919982298966 0.729340586412237 -0.455335415338948 0.847853810782231 1 0.00844525 0.015541 0.0160146 0.0223684 GeneID:10677,Genbank:XM_017018710.2,HGNC:HGNC:14188,MIM:613397 advillin GO:0003779,GO:0005737,GO:0007010,GO:0007399,GO:0010976,GO:0015629,GO:0030424,GO:0042995,GO:0043005,GO:0051015,GO:0051693,GO:0060271 actin binding|cytoplasm|cytoskeleton organization|nervous system development|positive regulation of neuron projection development|actin cytoskeleton|axon|cell projection|neuron projection|actin filament binding|actin filament capping|cilium assembly AVL9 1568.59087181821 1764.07940719424 1373.10233644217 0.778367646514328 -0.361476350317399 0.01432062864148 0.494308595521431 7.47661 7.40735 6.78136 4.94411 GeneID:23080,Genbank:NM_015060.2,HGNC:HGNC:28994,MIM:612927 AVL9 cell migration associated GO:0016021,GO:0016477,GO:0055037 integral component of membrane|cell migration|recycling endosome AVPI1 155.485363637643 147.182065718915 163.788661556371 1.11283029461736 0.154233600064067 0.545052485315345 1 4.04612 3.98553 4.08471 5.03132 GeneID:60370,Genbank:XM_017016494.1,HGNC:HGNC:30898 arginine vasopressin induced 1 GO:0000187,GO:0007049 activation of MAPK activity|cell cycle AVPR2 2.97301040229184 3.03648096111406 2.90953984346962 0.958194660440795 -0.0616093208420747 1 1 0.0326293 0.0558034 0.060254 0.0140671 GeneID:554,Genbank:XM_006724828.3,HGNC:HGNC:897,MIM:300538 arginine vasopressin receptor 2 GO:0001992,GO:0003084,GO:0003091,GO:0005000,GO:0005768,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0007186,GO:0007188,GO:0007190,GO:0007249,GO:0007588,GO:0007599,GO:0008284,GO:0010628,GO:0016021,GO:0021537,GO:0030665,GO:0031398,GO:0032609,GO:0032870,GO:0034097,GO:0035811,GO:0035814,GO:0042277,GO:0045907,GO:0061024,GO:1901652 regulation of systemic arterial blood pressure by vasopressin|positive regulation of systemic arterial blood pressure|renal water homeostasis|vasopressin receptor activity|endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|I-kappaB kinase/NF-kappaB signaling|excretion|hemostasis|positive regulation of cell proliferation|positive regulation of gene expression|integral component of membrane|telencephalon development|clathrin-coated vesicle membrane|positive regulation of protein ubiquitination|interferon-gamma production|cellular response to hormone stimulus|response to cytokine|negative regulation of urine volume|negative regulation of renal sodium excretion|peptide binding|positive regulation of vasoconstriction|membrane organization|response to peptide hsa04072,hsa04080,hsa04962 Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Vasopressin-regulated water reabsorption AXDND1 4.72584539906047 4.60274771635603 4.84894308176491 1.05348878117608 0.0751749506736706 1 1 0 0.0289317 0.00719537 0.00668278 GeneID:126859,Genbank:XM_011509167.3,HGNC:HGNC:26564 axonemal dynein light chain domain containing 1 AXIN1 758.731294786317 744.050454329966 773.412135242668 1.0394619487722 0.0558369469193056 0.798296644299205 1 4.23612 4.72968 4.71852 5.17488 GeneID:8312,Genbank:XM_011522684.2,HGNC:HGNC:903,MIM:603816 axin 1 hsa04310,hsa04390,hsa04550,hsa04934,hsa05165,hsa05200,hsa05210,hsa05213,hsa05217,hsa05224,hsa05225,hsa05226 Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Cushing syndrome|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer AXIN2 68.1808846982934 70.943666423377 65.4181029732098 0.922113365029772 -0.116983967755175 0.764339586808655 1 0.50809 0.467156 0.401365 0.512529 GeneID:8313,Genbank:NM_004655.3,HGNC:HGNC:904,MIM:604025 axin 2 hsa04310,hsa04390,hsa04550,hsa04934,hsa05165,hsa05200,hsa05210,hsa05213,hsa05217,hsa05224,hsa05225,hsa05226 Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Cushing syndrome|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer AXL 13648.985557135 15091.8185529758 12206.1525612941 0.808792692441119 -0.306158132545774 0.0168530966369807 0.538760869736292 113.362 122.417 106.411 87.8814 GeneID:558,Genbank:NM_021913.4,HGNC:HGNC:905,MIM:109135 AXL receptor tyrosine kinase hsa01521 EGFR tyrosine kinase inhibitor resistance AZGP1 317.258996348569 261.914574705021 372.603417992117 1.42261429480111 0.508544565304256 0.222044834916953 1 5.68506 6.27744 6.88187 10.6803 GeneID:563,Genbank:NM_001185.3,HGNC:HGNC:910,MIM:194460 alpha-2-glycoprotein 1, zinc-binding GO:0001580,GO:0001895,GO:0004540,GO:0005576,GO:0005615,GO:0005634,GO:0005886,GO:0007155,GO:0008285,GO:0008320,GO:0031012,GO:0055085,GO:0070062 detection of chemical stimulus involved in sensory perception of bitter taste|retina homeostasis|ribonuclease activity|extracellular region|extracellular space|nucleus|plasma membrane|cell adhesion|negative regulation of cell proliferation|protein transmembrane transporter activity|extracellular matrix|transmembrane transport|extracellular exosome AZI2 751.676007517001 716.191802656695 787.160212377308 1.09909134600167 0.136311294337304 0.592079334035998 1 5.56643 5.50844 7.10131 4.83646 GeneID:64343,Genbank:NM_022461.4,HGNC:HGNC:24002,MIM:609916 5-azacytidine induced 2 GO:0000278,GO:0005737,GO:0007249,GO:0016032,GO:0032607,GO:0032609,GO:0032635,GO:0032640,GO:0042110,GO:0044565,GO:0097028 mitotic cell cycle|cytoplasm|I-kappaB kinase/NF-kappaB signaling|viral process|interferon-alpha production|interferon-gamma production|interleukin-6 production|tumor necrosis factor production|T cell activation|dendritic cell proliferation|dendritic cell differentiation hsa04622 RIG-I-like receptor signaling pathway AZIN1 3008.02188657763 2882.68711308939 3133.35666006586 1.08695690414622 0.120294741278695 0.386620928380991 1 25.9375 24.329 30.5604 24.7342 GeneID:51582,Genbank:NM_001301668.1,HGNC:HGNC:16432,MIM:607909 antizyme inhibitor 1 GO:0003824,GO:0005634,GO:0005737,GO:0005829,GO:0006521,GO:0033387,GO:0042177,GO:0042978,GO:1902269 catalytic activity|nucleus|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|putrescine biosynthetic process from ornithine|negative regulation of protein catabolic process|ornithine decarboxylase activator activity|positive regulation of polyamine transmembrane transport AZIN2 59.0465064555728 60.4316529190636 57.661359992082 0.954158246661037 -0.0676995385724975 0.867504632223483 1 0.263146 0.520047 0.221015 0.331933 GeneID:113451,Genbank:XM_005270406.1,HGNC:HGNC:29957,MIM:608353 antizyme inhibitor 2 GO:0005634,GO:0005739,GO:0005801,GO:0005802,GO:0005829,GO:0007283,GO:0008792,GO:0015489,GO:0015847,GO:0030133,GO:0030424,GO:0030425,GO:0031410,GO:0033116,GO:0033387,GO:0042177,GO:0042978,GO:0043085,GO:0043204,GO:0048471,GO:0097055,GO:0098629,GO:1902269,GO:1990005 nucleus|mitochondrion|cis-Golgi network|trans-Golgi network|cytosol|spermatogenesis|arginine decarboxylase activity|putrescine transmembrane transporter activity|putrescine transport|transport vesicle|axon|dendrite|cytoplasmic vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|putrescine biosynthetic process from ornithine|negative regulation of protein catabolic process|ornithine decarboxylase activator activity|positive regulation of catalytic activity|perikaryon|perinuclear region of cytoplasm|agmatine biosynthetic process|trans-Golgi network membrane organization|positive regulation of polyamine transmembrane transport|granular vesicle hsa00330 Arginine and proline metabolism AZU1 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0 0 GeneID:566,Genbank:NM_001700.4,HGNC:HGNC:913,MIM:162815 azurocidin 1 GO:0001774,GO:0005576,GO:0005615,GO:0006508,GO:0006954,GO:0007205,GO:0008201,GO:0008233,GO:0008347,GO:0010628,GO:0010800,GO:0015643,GO:0019730,GO:0019898,GO:0035577,GO:0035578,GO:0035584,GO:0042117,GO:0042535,GO:0042582,GO:0043066,GO:0043114,GO:0043312,GO:0043395,GO:0045123,GO:0045348,GO:0045785,GO:0045860,GO:0048246,GO:0050725,GO:0050754,GO:0050766,GO:0050829,GO:0050930,GO:0051607,GO:0060326,GO:0070062,GO:0070528,GO:0070944 microglial cell activation|extracellular region|extracellular space|proteolysis|inflammatory response|protein kinase C-activating G-protein coupled receptor signaling pathway|heparin binding|peptidase activity|glial cell migration|positive regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|toxic substance binding|antimicrobial humoral response|extrinsic component of membrane|azurophil granule membrane|azurophil granule lumen|calcium-mediated signaling using intracellular calcium source|monocyte activation|positive regulation of tumor necrosis factor biosynthetic process|azurophil granule|negative regulation of apoptotic process|regulation of vascular permeability|neutrophil degranulation|heparan sulfate proteoglycan binding|cellular extravasation|positive regulation of MHC class II biosynthetic process|positive regulation of cell adhesion|positive regulation of protein kinase activity|macrophage chemotaxis|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of fractalkine biosynthetic process|positive regulation of phagocytosis|defense response to Gram-negative bacterium|induction of positive chemotaxis|defense response to virus|cell chemotaxis|extracellular exosome|protein kinase C signaling|neutrophil mediated killing of bacterium B2M 22340.4251640718 22648.3299406593 22032.5203874844 0.972809935443877 -0.0397701315844684 0.753826501918869 1 608.392 644.657 620.856 598.136 GeneID:567,Genbank:NM_004048.2,HGNC:HGNC:914,MIM:109700 beta-2-microglobulin hsa04612,hsa05163,hsa05169,hsa05170 Antigen processing and presentation|Human cytomegalovirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection B3GALNT1 135.479779592622 146.87429076059 124.085268424655 0.844839949742593 -0.243250038206137 0.403484421088455 1 1.26956 1.06803 1.17063 0.817342 GeneID:8706,Genbank:NM_001349142.1,HGNC:HGNC:918,MIM:603094 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) hsa00601,hsa00603 Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series B3GALNT2 641.643136314551 685.20265147465 598.083621154452 0.872856548157386 -0.196183524958734 0.242724242590667 1 3.81393 3.66926 3.62244 2.9803 GeneID:148789,Genbank:XM_006711749.3,HGNC:HGNC:28596,MIM:610194 beta-1,3-N-acetylgalactosaminyltransferase 2 GO:0000139,GO:0005783,GO:0005789,GO:0006486,GO:0006493,GO:0008375,GO:0008376,GO:0008378,GO:0016021 Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|protein O-linked glycosylation|acetylglucosaminyltransferase activity|acetylgalactosaminyltransferase activity|galactosyltransferase activity|integral component of membrane hsa00515 Mannose type O-glycan biosynthesis B3GALT1 3.45470718314052 2.54640955915669 4.36300480712434 1.7133947645756 0.776857585328211 0.715379976159873 1 0.0124529 0.01204 0.0361348 0.0168192 GeneID:8708,Genbank:XM_011512085.2,HGNC:HGNC:916,MIM:603093 beta-1,3-galactosyltransferase 1 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series B3GALT2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0112209 0 0 0 GeneID:8707,Genbank:NM_003783.3,HGNC:HGNC:917,MIM:603018 beta-1,3-galactosyltransferase 2 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series B3GALT4 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0320498 0 0 GeneID:8705,Genbank:NM_003782.3,HGNC:HGNC:919,MIM:603095 beta-1,3-galactosyltransferase 4 hsa00604 Glycosphingolipid biosynthesis - ganglio series B3GALT5 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0117385 0 0 GeneID:10317,Genbank:NM_001356336.1,HGNC:HGNC:920,MIM:604066 beta-1,3-galactosyltransferase 5 hsa00601,hsa00603 Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series B3GALT6 1398.46551002618 1446.35757859844 1350.57344145392 0.933775617757445 -0.0988521766859981 0.487365081444498 1 33.5398 34.5323 30.7141 33.817 GeneID:126792,Genbank:NM_080605.3,HGNC:HGNC:17978,MIM:615291 beta-1,3-galactosyltransferase 6 hsa00532,hsa00534 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin B3GAT2 4.96750957830066 4.60274771635603 5.33227144024528 1.15849743867057 0.212254854542529 0.959912101888044 1 0.0368446 0.0317063 0.135208 0.0314626 GeneID:135152,Genbank:NM_080742.2,HGNC:HGNC:922,MIM:607497 beta-1,3-glucuronyltransferase 2 GO:0000139,GO:0005975,GO:0006486,GO:0015018,GO:0016021,GO:0030203,GO:0030204,GO:0046872,GO:0050650 Golgi membrane|carbohydrate metabolic process|protein glycosylation|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|integral component of membrane|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|metal ion binding|chondroitin sulfate proteoglycan biosynthetic process hsa00515 Mannose type O-glycan biosynthesis B3GAT3 1938.47230510306 1910.82247878845 1966.12213141767 1.0289402355494 0.0411591878873806 0.795460124328371 1 24.6038 27.0466 26.9119 26.8444 GeneID:26229,Genbank:NM_012200.3,HGNC:HGNC:923,MIM:606374 beta-1,3-glucuronyltransferase 3 GO:0000139,GO:0005794,GO:0005801,GO:0005975,GO:0006024,GO:0006486,GO:0015012,GO:0015018,GO:0015020,GO:0016020,GO:0016021,GO:0030203,GO:0030204,GO:0043085,GO:0046872,GO:0050650,GO:0050651,GO:0070062,GO:0072542,GO:0090316 Golgi membrane|Golgi apparatus|cis-Golgi network|carbohydrate metabolic process|glycosaminoglycan biosynthetic process|protein glycosylation|heparan sulfate proteoglycan biosynthetic process|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|glucuronosyltransferase activity|membrane|integral component of membrane|glycosaminoglycan metabolic process|chondroitin sulfate metabolic process|positive regulation of catalytic activity|metal ion binding|chondroitin sulfate proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular exosome|protein phosphatase activator activity|positive regulation of intracellular protein transport hsa00532,hsa00534 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin B3GLCT 781.241755679242 822.448001984616 740.035509373867 0.899796105757588 -0.152329971820563 0.361309706727681 1 7.87485 6.89864 6.98135 6.6002 GeneID:145173,Genbank:NM_194318.3,HGNC:HGNC:20207,MIM:610308 beta 3-glucosyltransferase GO:0005789,GO:0006004,GO:0016021,GO:0016757,GO:0036066 endoplasmic reticulum membrane|fucose metabolic process|integral component of membrane|transferase activity, transferring glycosyl groups|protein O-linked fucosylation hsa00514 Other types of O-glycan biosynthesis B3GNT2 404.403958989882 435.635914367933 373.17200361183 0.856614414248347 -0.223282141228749 0.237558188886086 1 6.76491 5.73727 5.82513 5.22989 GeneID:10678,Genbank:NM_006577.5,HGNC:HGNC:15629,MIM:605581 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 hsa00533,hsa00601 Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT4 65.2594044798801 73.3459971584789 57.1728118012813 0.779494642055897 -0.359388988456866 0.321294422163009 1 0.576033 0.756978 0.381374 0.697136 GeneID:79369,Genbank:NM_030765.3,HGNC:HGNC:15683,MIM:605864 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 GO:0000139,GO:0008499,GO:0008532,GO:0016021,GO:0016266,GO:0018146,GO:0030311 Golgi membrane|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|integral component of membrane|O-glycan processing|keratan sulfate biosynthetic process|poly-N-acetyllactosamine biosynthetic process hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT5 368.346045023192 415.821335880683 320.870754165702 0.77165533963311 -0.373971484222784 0.296760200963711 1 2.94526 2.08575 2.34442 1.62724 GeneID:84002,Genbank:XM_011513227.2,HGNC:HGNC:15684,MIM:615333 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series B3GNT6 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0431249 0 GeneID:192134,Genbank:NM_138706.4,HGNC:HGNC:24141,MIM:615315 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 hsa00512 Mucin type O-glycan biosynthesis B3GNT7 1.05218221594214 2.10436443188427 0 0 -Inf 0.405312649089613 1 0.03992 0.011527 0 0 GeneID:93010,Genbank:NM_145236.2,HGNC:HGNC:18811,MIM:615313 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate B3GNT8 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0207791 0 0 0 GeneID:374907,Genbank:XM_011526934.2,HGNC:HGNC:24139,MIM:615357 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 GO:0000139,GO:0008499,GO:0016021,GO:0016262,GO:0016266,GO:0030311,GO:0070062 Golgi membrane|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity|integral component of membrane|protein N-acetylglucosaminyltransferase activity|O-glycan processing|poly-N-acetyllactosamine biosynthetic process|extracellular exosome B3GNT9 1246.20376153186 1113.19156251171 1379.215960552 1.23897450088469 0.309146495932304 0.0379657060040606 0.745170033530679 20.6141 20.9257 26.1505 26.4592 GeneID:84752,Genbank:NM_033309.2,HGNC:HGNC:28714 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 GO:0000139,GO:0001650,GO:0005794,GO:0006486,GO:0008378,GO:0016021 Golgi membrane|fibrillar center|Golgi apparatus|protein glycosylation|galactosyltransferase activity|integral component of membrane B3GNTL1 155.073721634046 164.27672985763 145.870713410462 0.88795725077362 -0.171437872795624 0.490546142497958 1 0.615178 0.647203 0.509186 0.518061 GeneID:146712,Genbank:NM_001009905.2,HGNC:HGNC:21727,MIM:615337 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1 GO:0016757 transferase activity, transferring glycosyl groups B4GALNT1 2271.46196585497 1956.32064992962 2586.60328178031 1.32217756934343 0.402915944779 0.00405519749271576 0.249352958245434 8.57327 9.2067 13.9018 11.0446 GeneID:2583,Genbank:XM_005268773.5,HGNC:HGNC:4117,MIM:601873 beta-1,4-N-acetyl-galactosaminyltransferase 1 hsa00604 Glycosphingolipid biosynthesis - ganglio series B4GALNT3 177.461854552319 144.587629885073 210.336079219565 1.45473080502635 0.540752210051435 0.0233839525516152 0.616997337836357 1.14546 1.08237 1.7544 1.62845 GeneID:283358,Genbank:NM_173593.3,HGNC:HGNC:24137,MIM:612220 beta-1,4-N-acetyl-galactosaminyltransferase 3 GO:0008376,GO:0016021,GO:0032580,GO:0033842 acetylgalactosaminyltransferase activity|integral component of membrane|Golgi cisterna membrane|N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity B4GALNT4 252.737708382563 267.535682844869 237.939733920257 0.889375695197365 -0.169135115537885 0.422828245450534 1 2.04083 2.02705 1.72667 2.02544 GeneID:338707,Genbank:NM_178537.4,HGNC:HGNC:26315 beta-1,4-N-acetyl-galactosaminyltransferase 4 GO:0008376,GO:0016021,GO:0032580,GO:0033842 acetylgalactosaminyltransferase activity|integral component of membrane|Golgi cisterna membrane|N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity B4GALT1 4685.92787184561 4572.66903039129 4799.18671329994 1.04953730116987 0.0697534417672676 0.614483398390198 1 51.1294 55.1116 56.6155 56.0107 GeneID:2683,Genbank:NM_001497.3,HGNC:HGNC:924,MIM:137060 beta-1,4-galactosyltransferase 1 hsa00052,hsa00510,hsa00514,hsa00515,hsa00533,hsa00601 Galactose metabolism|N-Glycan biosynthesis|Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT2 1755.59766575213 1701.10337871773 1810.09195278653 1.0640693419532 0.0895921696664627 0.539886459658139 1 31.1706 31.1923 34.1194 33.0726 GeneID:8704,Genbank:NM_003780.4,HGNC:HGNC:925,MIM:604013 beta-1,4-galactosyltransferase 2 hsa00052,hsa00510,hsa00514,hsa00515,hsa00533,hsa00601 Galactose metabolism|N-Glycan biosynthesis|Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT3 1414.01181113072 1491.90479301515 1336.11882924629 0.895579151901497 -0.159107150661127 0.265238407412434 1 16.3055 18.2434 15.9913 15.7115 GeneID:8703,Genbank:XM_017002714.2,HGNC:HGNC:926,MIM:604014 beta-1,4-galactosyltransferase 3 GO:0003831,GO:0003945,GO:0005975,GO:0006486,GO:0016021,GO:0032580,GO:0046872 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|N-acetyllactosamine synthase activity|carbohydrate metabolic process|protein glycosylation|integral component of membrane|Golgi cisterna membrane|metal ion binding hsa00510,hsa00514,hsa00515,hsa00533,hsa00601 N-Glycan biosynthesis|Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT4 432.528458671258 430.380416116204 434.676501226313 1.00998206458574 0.0143296736078058 0.943178174918333 1 4.39377 4.55566 4.24704 4.8907 GeneID:8702,Genbank:XM_006713798.3,HGNC:HGNC:927,MIM:604015 beta-1,4-galactosyltransferase 4 hsa00533,hsa00601 Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series B4GALT5 3407.29538649309 3683.07819533595 3131.51257765023 0.850243305074492 -0.234052353876452 0.0832362035029745 0.963076417285947 34.3407 35.2364 28.9047 30.4569 GeneID:9334,Genbank:NM_004776.3,HGNC:HGNC:928,MIM:604016 beta-1,4-galactosyltransferase 5 hsa00512 Mucin type O-glycan biosynthesis B4GALT6 100.811613902607 106.631617871148 94.991609934066 0.890839057218963 -0.166763283033706 0.59897226698894 1 0.408864 0.37329 0.334957 0.319687 GeneID:9331,Genbank:NM_001330570.1,HGNC:HGNC:929,MIM:604017 beta-1,4-galactosyltransferase 6 hsa00600 Sphingolipid metabolism B4GALT7 665.159560434697 641.722600871101 688.596519998292 1.07304389632461 0.101709095399632 0.559605443439457 1 11.1523 11.8616 12.1115 14.2373 GeneID:11285,Genbank:XM_006714816.4,HGNC:HGNC:930,MIM:604327 beta-1,4-galactosyltransferase 7 hsa00532,hsa00534 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin B4GAT1 873.438111355438 982.662115804242 764.214106906633 0.777697740266679 -0.362718548092971 0.0192181708928062 0.567967248609484 25.2245 26.3178 19.6671 21.22 GeneID:11041,Genbank:NM_006876.2,HGNC:HGNC:15685,MIM:605517 beta-1,4-glucuronyltransferase 1 hsa00515 Mannose type O-glycan biosynthesis B9D1 321.568712039444 297.622143463008 345.515280615881 1.16091926694569 0.215267647287975 0.295353507509456 1 1.45945 1.6478 1.71359 2.06129 GeneID:27077,Genbank:NM_001243475.2,HGNC:HGNC:24123,MIM:614144 B9 domain containing 1 GO:0001701,GO:0001944,GO:0005813,GO:0005829,GO:0007224,GO:0008158,GO:0016020,GO:0032880,GO:0035869,GO:0036038,GO:0036064,GO:0042733,GO:0043010,GO:0060271,GO:0060563,GO:0097711 in utero embryonic development|vasculature development|centrosome|cytosol|smoothened signaling pathway|hedgehog receptor activity|membrane|regulation of protein localization|ciliary transition zone|MKS complex|ciliary basal body|embryonic digit morphogenesis|camera-type eye development|cilium assembly|neuroepithelial cell differentiation|ciliary basal body-plasma membrane docking B9D2 124.936514596948 135.997684369012 113.875344824883 0.837332968963625 -0.256126664287579 0.511892276685751 1 2.78415 3.75012 2.45675 3.01837 GeneID:80776,Genbank:XM_011527350.2,HGNC:HGNC:28636,MIM:611951 B9 domain containing 2 GO:0005634,GO:0005813,GO:0005829,GO:0007062,GO:0016020,GO:0036038,GO:0036064,GO:0043015,GO:0060271,GO:0097711 nucleus|centrosome|cytosol|sister chromatid cohesion|membrane|MKS complex|ciliary basal body|gamma-tubulin binding|cilium assembly|ciliary basal body-plasma membrane docking BAALC 20.5314519256259 15.8645813062674 25.1983225449843 1.5883383279097 0.667518250017984 0.298526993221967 1 0.245639 0.277237 0.283973 0.450314 GeneID:79870,Genbank:NM_024812.2,HGNC:HGNC:14333,MIM:606602 BAALC, MAP3K1 and KLF4 binding BAAT 2.50695213767695 2.10436443188427 2.90953984346962 1.38262165972098 0.467406431746645 0.907553852302883 1 0.0360218 0.011532 0.0347323 0.0107754 GeneID:570,Genbank:NM_001701.3,HGNC:HGNC:932,MIM:602938 bile acid-CoA:amino acid N-acyltransferase GO:0001889,GO:0002152,GO:0005102,GO:0005777,GO:0005782,GO:0005829,GO:0006544,GO:0006631,GO:0006637,GO:0006699,GO:0008206,GO:0016290,GO:0016410,GO:0016746,GO:0019530,GO:0031100,GO:0047963,GO:0052689,GO:0052815,GO:0052816,GO:0052817,GO:0102991 liver development|bile acid conjugation|receptor binding|peroxisome|peroxisomal matrix|cytosol|glycine metabolic process|fatty acid metabolic process|acyl-CoA metabolic process|bile acid biosynthetic process|bile acid metabolic process|palmitoyl-CoA hydrolase activity|N-acyltransferase activity|transferase activity, transferring acyl groups|taurine metabolic process|animal organ regeneration|glycine N-choloyltransferase activity|carboxylic ester hydrolase activity|medium-chain acyl-CoA hydrolase activity|long-chain acyl-CoA hydrolase activity|very long chain acyl-CoA hydrolase activity|myristoyl-CoA hydrolase activity hsa00120,hsa00430,hsa01040,hsa04146,hsa04976 Primary bile acid biosynthesis|Taurine and hypotaurine metabolism|Biosynthesis of unsaturated fatty acids|Peroxisome|Bile secretion BABAM1 3607.58049360354 3420.65698292132 3794.50400428576 1.10929099972052 0.149637876575178 0.276917753441793 1 72.3424 76.0876 83.0474 86.3971 GeneID:29086,Genbank:NM_001033549.2,HGNC:HGNC:25008,MIM:612766 BRISC and BRCA1 A complex member 1 GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006302,GO:0006303,GO:0007049,GO:0010212,GO:0016569,GO:0016579,GO:0016604,GO:0045739,GO:0051301,GO:0070531,GO:0070536,GO:0070552,GO:0072425 nucleus|nucleoplasm|cytoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|cell cycle|response to ionizing radiation|covalent chromatin modification|protein deubiquitination|nuclear body|positive regulation of DNA repair|cell division|BRCA1-A complex|protein K63-linked deubiquitination|BRISC complex|signal transduction involved in G2 DNA damage checkpoint hsa03440 Homologous recombination BABAM2 779.036669683033 737.553030588971 820.520308777094 1.11248991563613 0.153792258571 0.329253608696335 1 10.8129 10.4853 13.0108 10.8854 GeneID:9577,Genbank:NM_001329112.1,HGNC:HGNC:1106,MIM:610497 BRISC and BRCA1 A complex member 2 GO:0005634,GO:0005737,GO:0006302,GO:0006915,GO:0007049,GO:0010212,GO:0016569,GO:0031593,GO:0045739,GO:0051301,GO:0070531,GO:0070552,GO:0072425 nucleus|cytoplasm|double-strand break repair|apoptotic process|cell cycle|response to ionizing radiation|covalent chromatin modification|polyubiquitin modification-dependent protein binding|positive regulation of DNA repair|cell division|BRCA1-A complex|BRISC complex|signal transduction involved in G2 DNA damage checkpoint hsa03440 Homologous recombination BACE1 1645.7134835514 1377.13406640947 1914.29290069333 1.39005558528108 0.475142574319991 0.00101055734809324 0.103795225877033 7.9891 8.8933 12.096 11.4322 GeneID:23621,Genbank:NM_138973.3,HGNC:HGNC:933,MIM:604252 beta-secretase 1 GO:0001540,GO:0004190,GO:0005768,GO:0005771,GO:0005783,GO:0005794,GO:0005802,GO:0005887,GO:0006508,GO:0006509,GO:0009986,GO:0019899,GO:0030424,GO:0030659,GO:0045121,GO:0050435,GO:0050804 amyloid-beta binding|aspartic-type endopeptidase activity|endosome|multivesicular body|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|integral component of plasma membrane|proteolysis|membrane protein ectodomain proteolysis|cell surface|enzyme binding|axon|cytoplasmic vesicle membrane|membrane raft|amyloid-beta metabolic process|modulation of chemical synaptic transmission hsa05010 Alzheimer disease BACE2 2398.51122617955 2286.13158444094 2510.89086791815 1.09831423746861 0.13529088128106 0.331695472280814 1 9.86047 10.164 11.4593 10.6199 GeneID:25825,Genbank:NM_012105.4,HGNC:HGNC:934,MIM:605668 beta-site APP-cleaving enzyme 2 GO:0001540,GO:0004190,GO:0005768,GO:0005783,GO:0005794,GO:0006508,GO:0006509,GO:0009986,GO:0016021,GO:0016486,GO:0030163,GO:0042985,GO:0050435 amyloid-beta binding|aspartic-type endopeptidase activity|endosome|endoplasmic reticulum|Golgi apparatus|proteolysis|membrane protein ectodomain proteolysis|cell surface|integral component of membrane|peptide hormone processing|protein catabolic process|negative regulation of amyloid precursor protein biosynthetic process|amyloid-beta metabolic process hsa05010 Alzheimer disease BACH1 95.8380000936113 95.2257054571815 96.4502947300411 1.01285986033897 0.018434576133014 0.957637807883484 1 0.728305 0.683982 0.832417 0.638378 GeneID:571,Genbank:NM_001186.3,HGNC:HGNC:935,MIM:602751 BTB domain and CNC homolog 1 GO:0000083,GO:0000117,GO:0000122,GO:0000980,GO:0001078,GO:0001205,GO:0001206,GO:0003700,GO:0005634,GO:0005737,GO:0006281,GO:0006355,GO:0016567,GO:0020037,GO:0031463,GO:0061418 regulation of transcription involved in G1/S transition of mitotic cell cycle|regulation of transcription involved in G2/M transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding|DNA binding transcription factor activity|nucleus|cytoplasm|DNA repair|regulation of transcription, DNA-templated|protein ubiquitination|heme binding|Cul3-RING ubiquitin ligase complex|regulation of transcription from RNA polymerase II promoter in response to hypoxia BACH2 21.6480830389187 20.5153552973084 22.780810780529 1.11042730922227 0.151114954292376 0.840904993245323 1 0.0386792 0.0454812 0.0600592 0.0387678 GeneID:60468,Genbank:NM_001170794.1,HGNC:HGNC:14078,MIM:605394 BTB domain and CNC homolog 2 BAD 1503.26353577439 1538.71151622963 1467.81555531915 0.953925111911686 -0.0680520832838281 0.700557592623635 1 50.4901 51.9392 46.1525 55.4346 GeneID:572,Genbank:NM_032989.2,HGNC:HGNC:936,MIM:603167 BCL2 associated agonist of cell death hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04022,hsa04024,hsa04062,hsa04140,hsa04151,hsa04210,hsa04370,hsa04510,hsa04722,hsa04910,hsa04919,hsa05010,hsa05014,hsa05145,hsa05152,hsa05160,hsa05161,hsa05165,hsa05170,hsa05200,hsa05203,hsa05210,hsa05211,hsa05212,hsa05213,hsa05215,hsa05218,hsa05220,hsa05221,hsa05223,hsa05225 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Autophagy - animal|PI3K-Akt signaling pathway|Apoptosis|VEGF signaling pathway|Focal adhesion|Neurotrophin signaling pathway|Insulin signaling pathway|Thyroid hormone signaling pathway|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Hepatocellular carcinoma BAG1 1574.26798753775 1571.63051005333 1576.90546502217 1.00335635821212 0.00483409340399137 0.983770101049512 1 15.0299 16.2809 15.4221 16.2541 GeneID:573,Genbank:NM_001349286.1,HGNC:HGNC:937,MIM:601497 BCL2 associated athanogene 1 hsa04141 Protein processing in endoplasmic reticulum BAG2 968.78731490525 1009.89337490404 927.681254906456 0.918593267328445 -0.122501885275229 0.437880622632216 1 12.7939 13.1371 13.7054 10.2065 GeneID:9532,Genbank:NM_004282.3,HGNC:HGNC:938,MIM:603882 BCL2 associated athanogene 2 GO:0000774,GO:0005829,GO:0006457,GO:0019538,GO:0042802,GO:0051087,GO:1900034 adenyl-nucleotide exchange factor activity|cytosol|protein folding|protein metabolic process|identical protein binding|chaperone binding|regulation of cellular response to heat hsa04141 Protein processing in endoplasmic reticulum BAG3 3252.00328489782 3160.08714390748 3343.91942588816 1.05817316852641 0.0815757417535162 0.559434659547917 1 43.2562 45.2239 48.4034 46.8712 GeneID:9531,Genbank:NM_004281.3,HGNC:HGNC:939,MIM:603883 BCL2 associated athanogene 3 BAG4 298.783401259365 329.542394173428 268.024408345302 0.81332299905623 -0.298099684045758 0.144287589352633 1 3.35542 3.05896 3.0033 2.30863 GeneID:9530,Genbank:NM_004874.3,HGNC:HGNC:940,MIM:603884 BCL2 associated athanogene 4 GO:0000774,GO:0003723,GO:0005057,GO:0005634,GO:0005829,GO:0005886,GO:0006457,GO:0010763,GO:0030838,GO:0031625,GO:0033138,GO:0033209,GO:0043066,GO:0045785,GO:0051087,GO:0051291,GO:0051496,GO:0051897,GO:0071356,GO:0071364,GO:0072659,GO:0090367,GO:0097178,GO:1900034,GO:1903215,GO:2001145 adenyl-nucleotide exchange factor activity|RNA binding|signal transducer activity, downstream of receptor|nucleus|cytosol|plasma membrane|protein folding|positive regulation of fibroblast migration|positive regulation of actin filament polymerization|ubiquitin protein ligase binding|positive regulation of peptidyl-serine phosphorylation|tumor necrosis factor-mediated signaling pathway|negative regulation of apoptotic process|positive regulation of cell adhesion|chaperone binding|protein heterooligomerization|positive regulation of stress fiber assembly|positive regulation of protein kinase B signaling|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|protein localization to plasma membrane|negative regulation of mRNA modification|ruffle assembly|regulation of cellular response to heat|negative regulation of protein targeting to mitochondrion|negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity hsa04668 TNF signaling pathway BAG5 1163.12096851888 1190.22577416583 1136.01616287193 0.954454345998443 -0.0672519034151522 0.670799959010946 1 10.5215 10.0074 10.5107 9.1004 GeneID:9529,Genbank:NM_001015048.2,HGNC:HGNC:941,MIM:603885 BCL2 associated athanogene 5 GO:0000774,GO:0005634,GO:0005739,GO:0005829,GO:0006457,GO:0007030,GO:0010977,GO:0016020,GO:0016234,GO:0019901,GO:0031397,GO:0031625,GO:0032435,GO:0048471,GO:0051087,GO:0051438,GO:0051444,GO:0061084,GO:0070997,GO:0090083,GO:1900034,GO:1902176 adenyl-nucleotide exchange factor activity|nucleus|mitochondrion|cytosol|protein folding|Golgi organization|negative regulation of neuron projection development|membrane|inclusion body|protein kinase binding|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|perinuclear region of cytoplasm|chaperone binding|regulation of ubiquitin-protein transferase activity|negative regulation of ubiquitin-protein transferase activity|negative regulation of protein refolding|neuron death|regulation of inclusion body assembly|regulation of cellular response to heat|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway BAG6 8312.09817876813 8259.677605598 8364.51875193825 1.01269312815178 0.0181970669673396 0.900124740792466 1 49.4986 49.4265 51.4869 51.4799 GeneID:7917,Genbank:NM_001199697.1,HGNC:HGNC:13919,MIM:142590 BCL2 associated athanogene 6 GO:0001822,GO:0002429,GO:0005102,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0006915,GO:0007130,GO:0007283,GO:0007420,GO:0009790,GO:0010498,GO:0016020,GO:0016569,GO:0018393,GO:0030101,GO:0030154,GO:0030324,GO:0030433,GO:0030544,GO:0031593,GO:0031625,GO:0032435,GO:0042127,GO:0042771,GO:0042802,GO:0043022,GO:0043066,GO:0043231,GO:0045861,GO:0050821,GO:0051787,GO:0061857,GO:0070059,GO:0070062,GO:0070628,GO:0071712,GO:0071816,GO:0071818,GO:1904294,GO:1904378,GO:1904379,GO:1990381 kidney development|immune response-activating cell surface receptor signaling pathway|receptor binding|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|apoptotic process|synaptonemal complex assembly|spermatogenesis|brain development|embryo development|proteasomal protein catabolic process|membrane|covalent chromatin modification|internal peptidyl-lysine acetylation|natural killer cell activation|cell differentiation|lung development|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|ribosome binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|negative regulation of proteolysis|protein stabilization|misfolded protein binding|endoplasmic reticulum stress-induced pre-emptive quality control|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|extracellular exosome|proteasome binding|ER-associated misfolded protein catabolic process|tail-anchored membrane protein insertion into ER membrane|BAT3 complex|positive regulation of ERAD pathway|maintenance of unfolded protein involved in ERAD pathway|protein localization to cytosolic proteasome complex involved in ERAD pathway|ubiquitin-specific protease binding BAHCC1 33.3174705068182 31.7291626125348 34.9057784011015 1.10011659706745 0.137656437474026 0.851717768710349 1 0.126026 0.117618 0.181004 0.0695386 GeneID:57597,Genbank:XM_017024898.2,HGNC:HGNC:29279,MIM:617646 BAH domain and coiled-coil containing 1 GO:0000785,GO:0000976,GO:0003682,GO:0005677,GO:0006342,GO:0031507 chromatin|transcription regulatory region sequence-specific DNA binding|chromatin binding|chromatin silencing complex|chromatin silencing|heterochromatin assembly BAHD1 1216.44179232332 1117.62182243955 1315.26176220709 1.17683972860885 0.234917856072736 0.119247720542044 1 8.84464 9.45539 11.0957 10.9868 GeneID:22893,Genbank:NM_001301132.1,HGNC:HGNC:29153,MIM:613880 bromo adjacent homology domain containing 1 GO:0000785,GO:0000976,GO:0003682,GO:0005654,GO:0005677,GO:0006342,GO:0006351,GO:0016569,GO:0031507,GO:0045892 chromatin|transcription regulatory region sequence-specific DNA binding|chromatin binding|nucleoplasm|chromatin silencing complex|chromatin silencing|transcription, DNA-templated|covalent chromatin modification|heterochromatin assembly|negative regulation of transcription, DNA-templated BAIAP2 557.051322339133 538.3774039896 575.725240688665 1.06937110737245 0.0967626031568349 0.592305310877728 1 1.76946 1.82479 1.97932 1.94762 GeneID:10458,Genbank:XM_024450534.1,HGNC:HGNC:947,MIM:605475 BAI1 associated protein 2 GO:0001221,GO:0001726,GO:0005737,GO:0005791,GO:0005794,GO:0005829,GO:0005874,GO:0005886,GO:0005913,GO:0007009,GO:0007409,GO:0007420,GO:0008022,GO:0008093,GO:0008286,GO:0008360,GO:0009617,GO:0014069,GO:0016358,GO:0030141,GO:0030165,GO:0030175,GO:0030838,GO:0032956,GO:0035418,GO:0038096,GO:0042802,GO:0043025,GO:0043198,GO:0044306,GO:0048010,GO:0048167,GO:0051017,GO:0051764,GO:0060076,GO:0061003,GO:0061845,GO:0061846,GO:0070062,GO:0070064,GO:0071364,GO:0097060,GO:0097110,GO:0098641,GO:0098793,GO:1905232,GO:2000251,GO:2000463 transcription cofactor binding|ruffle|cytoplasm|rough endoplasmic reticulum|Golgi apparatus|cytosol|microtubule|plasma membrane|cell-cell adherens junction|plasma membrane organization|axonogenesis|brain development|protein C-terminus binding|cytoskeletal adaptor activity|insulin receptor signaling pathway|regulation of cell shape|response to bacterium|postsynaptic density|dendrite development|secretory granule|PDZ domain binding|filopodium|positive regulation of actin filament polymerization|regulation of actin cytoskeleton organization|protein localization to synapse|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|neuronal cell body|dendritic shaft|neuron projection terminus|vascular endothelial growth factor receptor signaling pathway|regulation of synaptic plasticity|actin filament bundle assembly|actin crosslink formation|excitatory synapse|positive regulation of dendritic spine morphogenesis|neuron projection branch point|dendritic spine cytoplasm|extracellular exosome|proline-rich region binding|cellular response to epidermal growth factor stimulus|synaptic membrane|scaffold protein binding|cadherin binding involved in cell-cell adhesion|presynapse|cellular response to L-glutamate|positive regulation of actin cytoskeleton reorganization|positive regulation of excitatory postsynaptic potential hsa04520,hsa04810 Adherens junction|Regulation of actin cytoskeleton BAIAP2L1 157.704850084898 164.218894927837 151.190805241959 0.920666317407613 -0.119249728418169 0.642422343217315 1 1.63187 1.51569 1.31871 1.54701 GeneID:55971,Genbank:NM_018842.4,HGNC:HGNC:21649,MIM:611877 BAI1 associated protein 2 like 1 GO:0003779,GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0005913,GO:0007009,GO:0008286,GO:0009617,GO:0030838,GO:0046626,GO:0051017,GO:0051764,GO:0070062,GO:0070064,GO:0098641,GO:2000251 actin binding|nucleoplasm|cytosol|cytoskeleton|plasma membrane|cell-cell adherens junction|plasma membrane organization|insulin receptor signaling pathway|response to bacterium|positive regulation of actin filament polymerization|regulation of insulin receptor signaling pathway|actin filament bundle assembly|actin crosslink formation|extracellular exosome|proline-rich region binding|cadherin binding involved in cell-cell adhesion|positive regulation of actin cytoskeleton reorganization BAIAP2L2 0.780196841909191 1.07619535328461 0.484198330533773 0.449916763769675 -1.15226997256519 0.981239839765731 1 0.0254231 0 0 0 GeneID:80115,Genbank:XM_005261751.4,HGNC:HGNC:26203,MIM:617536 BAI1 associated protein 2 like 2 GO:0005543,GO:0005829,GO:0005886,GO:0007009,GO:0008286,GO:0012506,GO:0015629,GO:0030659,GO:0030838,GO:0044291,GO:0051017,GO:0051764,GO:0061024,GO:2000251 phospholipid binding|cytosol|plasma membrane|plasma membrane organization|insulin receptor signaling pathway|vesicle membrane|actin cytoskeleton|cytoplasmic vesicle membrane|positive regulation of actin filament polymerization|cell-cell contact zone|actin filament bundle assembly|actin crosslink formation|membrane organization|positive regulation of actin cytoskeleton reorganization BAIAP3 38.0558870190719 31.5272488586871 44.5845251794566 1.41415844367821 0.499943770149321 0.273893867055111 1 0.0189789 0.00803964 0.0610207 0.0326294 GeneID:8938,Genbank:NM_001286464.1,HGNC:HGNC:948,MIM:604009 BAI1 associated protein 3 GO:0005783,GO:0007186,GO:0007269,GO:0008022,GO:0098793 endoplasmic reticulum|G-protein coupled receptor signaling pathway|neurotransmitter secretion|protein C-terminus binding|presynapse hsa05202 Transcriptional misregulation in cancer BAK1 935.25418435707 922.096192716232 948.412175997908 1.02853930369689 0.0405969247964172 0.809576208767846 1 14.7876 15.1887 16.0261 15.2994 GeneID:578,Genbank:NM_001188.3,HGNC:HGNC:949,MIM:600516 BCL2 antagonist/killer 1 hsa01524,hsa04141,hsa04210,hsa04215,hsa05163,hsa05165,hsa05167,hsa05169,hsa05170,hsa05200,hsa05202,hsa05203,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 Platinum drug resistance|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer BAMBI 175.5554547592 164.026789829097 187.084119689303 1.14057051219639 0.189755639505373 0.434983192167127 1 4.73767 5.0689 6.52398 5.01861 GeneID:25805,Genbank:NM_012342.2,HGNC:HGNC:30251,MIM:604444 BMP and activin membrane bound inhibitor GO:0005109,GO:0005114,GO:0005737,GO:0005886,GO:0008284,GO:0008360,GO:0010718,GO:0016021,GO:0016477,GO:0030512,GO:0032092,GO:0035413,GO:0045893,GO:0090263 frizzled binding|type II transforming growth factor beta receptor binding|cytoplasm|plasma membrane|positive regulation of cell proliferation|regulation of cell shape|positive regulation of epithelial to mesenchymal transition|integral component of membrane|cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of protein binding|positive regulation of catenin import into nucleus|positive regulation of transcription, DNA-templated|positive regulation of canonical Wnt signaling pathway hsa04310,hsa04350 Wnt signaling pathway|TGF-beta signaling pathway BANF1 2937.39556696436 3100.96404306172 2773.827090867 0.894504757987544 -0.16083893870657 0.263981375968624 1 68.4554 76.8551 63.652 69.6735 GeneID:8815,Genbank:NM_003860.3,HGNC:HGNC:17397,MIM:603811 barrier to autointegration factor 1 GO:0003677,GO:0005634,GO:0005635,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0007077,GO:0007084,GO:0008022,GO:0009615,GO:0019899,GO:0042802,GO:0042803,GO:0045071,GO:0047485,GO:0051169,GO:0070062,GO:0075713,GO:0097726 DNA binding|nucleus|nuclear envelope|nucleoplasm|chromosome|cytoplasm|cytosol|mitotic nuclear envelope disassembly|mitotic nuclear envelope reassembly|protein C-terminus binding|response to virus|enzyme binding|identical protein binding|protein homodimerization activity|negative regulation of viral genome replication|protein N-terminus binding|nuclear transport|extracellular exosome|establishment of integrated proviral latency|LEM domain binding BANP 389.233778808737 362.156664041362 416.310893576112 1.14953260539357 0.201047387302281 0.295861314859721 1 1.04297 1.42343 1.67055 1.51822 GeneID:54971,Genbank:XM_011523176.2,HGNC:HGNC:13450,MIM:611564 BTG3 associated nuclear protein GO:0002039,GO:0003677,GO:0005654,GO:0006351,GO:0007049,GO:0007275,GO:0016569,GO:0016604,GO:0034504,GO:0042177,GO:0042802,GO:0045893,GO:1901796 p53 binding|DNA binding|nucleoplasm|transcription, DNA-templated|cell cycle|multicellular organism development|covalent chromatin modification|nuclear body|protein localization to nucleus|negative regulation of protein catabolic process|identical protein binding|positive regulation of transcription, DNA-templated|regulation of signal transduction by p53 class mediator BAP1 4852.34637888726 4727.06789697062 4977.62486080391 1.05300473132486 0.0745119186462269 0.590389869053559 1 42.1829 43.6537 46.5813 44.8838 GeneID:8314,Genbank:NM_004656.3,HGNC:HGNC:950,MIM:603089 BRCA1 associated protein 1 BARD1 290.312685415114 283.02484560791 297.600525222319 1.05149964690592 0.0724483656120896 0.757316861651343 1 2.3208 1.96269 2.64091 1.93838 GeneID:580,Genbank:XM_017004613.1,HGNC:HGNC:952,MIM:601593 BRCA1 associated RING domain 1 hsa03440 Homologous recombination BARX1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0446237 0 GeneID:56033,Genbank:NM_021570.3,HGNC:HGNC:955,MIM:603260 BARX homeobox 1 GO:0000977,GO:0001228,GO:0003700,GO:0005634,GO:0006357,GO:0007267,GO:0009888,GO:0009952,GO:0030178,GO:0030855,GO:0048513,GO:0048536,GO:0055123 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|regulation of transcription from RNA polymerase II promoter|cell-cell signaling|tissue development|anterior/posterior pattern specification|negative regulation of Wnt signaling pathway|epithelial cell differentiation|animal organ development|spleen development|digestive system development BASP1 109.561429515907 106.199381398983 112.92347763283 1.06331577590443 0.0885701017410239 0.770983875500232 1 2.55381 2.4831 2.96718 2.47448 GeneID:10409,Genbank:NM_001271606.1,HGNC:HGNC:957,MIM:605940 brain abundant membrane attached signal protein 1 BATF2 1.69980562271349 0.490071401957362 2.90953984346962 5.93697128999738 2.56972713653953 0.446122233660411 1 0 0 0.0922197 0.0172455 GeneID:116071,Genbank:NM_138456.3,HGNC:HGNC:25163,MIM:614983 basic leucine zipper ATF-like transcription factor 2 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006357,GO:0042832,GO:0043011 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|defense response to protozoan|myeloid dendritic cell differentiation BATF3 118.270205963465 117.31713616484 119.22327576209 1.01624775083643 0.0232521593254246 0.955716887397435 1 2.80275 2.94152 3.20208 2.63734 GeneID:55509,Genbank:NM_018664.2,HGNC:HGNC:28915,MIM:612470 basic leucine zipper ATF-like transcription factor 3 GO:0000122,GO:0000978,GO:0001078,GO:0003700,GO:0003714,GO:0005634,GO:0006366,GO:0009615,GO:0043011,GO:0097028 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|transcription from RNA polymerase II promoter|response to virus|myeloid dendritic cell differentiation|dendritic cell differentiation BAX 2107.91477148943 2140.32469737938 2075.50484559947 0.969714944718773 -0.0443673767416597 0.751750140919608 1 55.2566 56.1484 51.9106 58.7047 GeneID:581,Genbank:XM_017027077.1,HGNC:HGNC:959,MIM:600040 BCL2 associated X, apoptosis regulator hsa01521,hsa01522,hsa01524,hsa04071,hsa04115,hsa04141,hsa04210,hsa04211,hsa04215,hsa04217,hsa04722,hsa04932,hsa04933,hsa05014,hsa05016,hsa05020,hsa05152,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05170,hsa05200,hsa05202,hsa05203,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|Sphingolipid signaling pathway|p53 signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Longevity regulating pathway|Apoptosis - multiple species|Necroptosis|Neurotrophin signaling pathway|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Amyotrophic lateral sclerosis (ALS)|Huntington disease|Prion diseases|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer BAZ1A 330.072956036185 316.944616546591 343.20129552578 1.08284311393353 0.114824235424857 0.782253598299943 1 1.49822 1.17942 1.92944 1.01601 GeneID:11177,Genbank:NM_182648.1,HGNC:HGNC:960,MIM:605680 bromodomain adjacent to zinc finger domain 1A GO:0006261,GO:0006338,GO:0006351,GO:0006355,GO:0008623,GO:0016590,GO:0046872 DNA-dependent DNA replication|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|CHRAC|ACF complex|metal ion binding BAZ1B 5001.31019159869 5074.29376888321 4928.32661431417 0.971233996055935 -0.0421091738261805 0.839915110423213 1 23.8008 22.6741 26.6427 19.0331 GeneID:9031,Genbank:NM_032408.3,HGNC:HGNC:961,MIM:605681 bromodomain adjacent to zinc finger domain 1B GO:0000793,GO:0004713,GO:0004715,GO:0005524,GO:0005654,GO:0005721,GO:0006333,GO:0006338,GO:0006351,GO:0006355,GO:0006974,GO:0008270,GO:0016572,GO:0016604,GO:0035173,GO:0042393,GO:0045815 condensed chromosome|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|ATP binding|nucleoplasm|pericentric heterochromatin|chromatin assembly or disassembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|zinc ion binding|histone phosphorylation|nuclear body|histone kinase activity|histone binding|positive regulation of gene expression, epigenetic BAZ2A 2516.91755191957 2508.76502875107 2525.07007508807 1.00649923215213 0.00934607164252082 0.960721014071707 1 8.39692 8.86828 9.58704 7.90415 GeneID:11176,Genbank:NM_013449.3,HGNC:HGNC:962,MIM:605682 bromodomain adjacent to zinc finger domain 2A GO:0000183,GO:0001164,GO:0003723,GO:0005677,GO:0005730,GO:0005829,GO:0006306,GO:0006338,GO:0006351,GO:0006355,GO:0016575,GO:0016607,GO:0016922,GO:0033553,GO:0042393,GO:0046872,GO:0070577 chromatin silencing at rDNA|RNA polymerase I CORE element sequence-specific DNA binding|RNA binding|chromatin silencing complex|nucleolus|cytosol|DNA methylation|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|histone deacetylation|nuclear speck|ligand-dependent nuclear receptor binding|rDNA heterochromatin|histone binding|metal ion binding|lysine-acetylated histone binding BAZ2B 93.3703954908127 94.6395815058543 92.1012094757711 0.973178537038162 -0.0392235921717041 0.940232636115599 1 0.224918 0.200064 0.289236 0.1559 GeneID:29994,Genbank:XM_024452826.1,HGNC:HGNC:963,MIM:605683 bromodomain adjacent to zinc finger domain 2B GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding BBC3 71.2524233872506 64.9765657056267 77.5282810688745 1.19317295746458 0.25480318535545 0.475456069496345 1 1.20818 1.06816 1.14824 1.68786 GeneID:27113,Genbank:XM_006723141.3,HGNC:HGNC:17868,MIM:605854 BCL2 binding component 3 GO:0005739,GO:0006915,GO:0051117,GO:0090200,GO:0097193 mitochondrion|apoptotic process|ATPase binding|positive regulation of release of cytochrome c from mitochondria|intrinsic apoptotic signaling pathway hsa01524,hsa04115,hsa04210,hsa04215,hsa04390,hsa05016,hsa05162,hsa05200,hsa05210 Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Hippo signaling pathway|Huntington disease|Measles|Pathways in cancer|Colorectal cancer BBIP1 488.997445149533 520.051640017584 457.943250281483 0.880572649027699 -0.183486060656735 0.307964393285747 1 6.49015 5.61397 4.66911 5.88685 GeneID:92482,Genbank:NM_001243783.1,HGNC:HGNC:28093,MIM:613605 BBSome interacting protein 1 GO:0005737,GO:0005829,GO:0015031,GO:0034464,GO:0060271,GO:0097500 cytoplasm|cytosol|protein transport|BBSome|cilium assembly|receptor localization to non-motile cilium BBOF1 29.1403726275847 32.6034442119717 25.6773010431977 0.787564064589507 -0.34453081023661 0.579355728186078 1 0.162938 0.0649276 0.0573473 0.113167 GeneID:80127,Genbank:XM_011537172.1,HGNC:HGNC:19855 basal body orientation factor 1 GO:0005737,GO:0036064,GO:0044458 cytoplasm|ciliary basal body|motile cilium assembly BBOX1 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0130664 GeneID:8424,Genbank:XM_005253159.2,HGNC:HGNC:964,MIM:603312 gamma-butyrobetaine hydroxylase 1 GO:0005506,GO:0005739,GO:0005829,GO:0008270,GO:0008336,GO:0042802,GO:0045329,GO:0070062 iron ion binding|mitochondrion|cytosol|zinc ion binding|gamma-butyrobetaine dioxygenase activity|identical protein binding|carnitine biosynthetic process|extracellular exosome hsa00310 Lysine degradation BBS1 221.448550771235 187.030719755769 255.866381786701 1.36804468335907 0.452115352597901 0.039131181873605 0.753859521009372 2.02424 1.87806 2.45598 2.85059 GeneID:582,Genbank:NM_024649.4,HGNC:HGNC:966,MIM:209901 Bardet-Biedl syndrome 1 BBS10 131.798358100324 133.700197837534 129.896518363114 0.971550681779532 -0.0416388376821771 0.91998826141753 1 1.73016 1.40518 1.8304 1.31138 GeneID:79738,Genbank:NM_024685.3,HGNC:HGNC:26291,MIM:610148 Bardet-Biedl syndrome 10 GO:0001103,GO:0001895,GO:0005524,GO:0005929,GO:0007601,GO:0043254,GO:0045494,GO:0050896,GO:0051131,GO:1905515 RNA polymerase II repressing transcription factor binding|retina homeostasis|ATP binding|cilium|visual perception|regulation of protein complex assembly|photoreceptor cell maintenance|response to stimulus|chaperone-mediated protein complex assembly|non-motile cilium assembly BBS12 32.2722399927707 33.0454893392442 31.4989906462972 0.953200914137761 -0.0691477597866003 0.93867159665173 1 0.403135 0.313278 0.315485 0.394466 GeneID:166379,Genbank:XM_011531680.2,HGNC:HGNC:26648,MIM:610683 Bardet-Biedl syndrome 12 GO:0005524,GO:0005832,GO:0005929,GO:0006458,GO:0042073,GO:0042755,GO:0044183,GO:0045494,GO:0045599,GO:0051082,GO:0051131,GO:0061077 ATP binding|chaperonin-containing T-complex|cilium|'de novo' protein folding|intraciliary transport|eating behavior|protein binding involved in protein folding|photoreceptor cell maintenance|negative regulation of fat cell differentiation|unfolded protein binding|chaperone-mediated protein complex assembly|chaperone-mediated protein folding BBS2 865.516728430734 804.423255318381 926.610201543087 1.15189385117459 0.204007776294229 0.195770748366019 1 8.61764 9.21754 10.9422 10.0682 GeneID:583,Genbank:XM_005256080.2,HGNC:HGNC:967,MIM:606151 Bardet-Biedl syndrome 2 BBS4 459.918656676808 449.319696003162 470.517617350453 1.04717781467372 0.0665064380344082 0.757448388095576 1 4.84351 4.64069 4.42494 5.52087 GeneID:585,Genbank:NM_033028.4,HGNC:HGNC:969,MIM:600374 Bardet-Biedl syndrome 4 BBS5 135.943575270073 147.335953198078 124.551197342068 0.845355085697391 -0.242370631871603 0.352843772638865 1 2.04479 2.4035 1.91827 1.68218 GeneID:129880,Genbank:NM_152384.2,HGNC:HGNC:970,MIM:603650 Bardet-Biedl syndrome 5 GO:0001103,GO:0001947,GO:0005622,GO:0005829,GO:0005930,GO:0007601,GO:0015031,GO:0032266,GO:0032402,GO:0034464,GO:0036064,GO:0044458,GO:0046907,GO:0050896,GO:0060170,GO:0060271 RNA polymerase II repressing transcription factor binding|heart looping|intracellular|cytosol|axoneme|visual perception|protein transport|phosphatidylinositol-3-phosphate binding|melanosome transport|BBSome|ciliary basal body|motile cilium assembly|intracellular transport|response to stimulus|ciliary membrane|cilium assembly BBS7 189.814942626995 187.232633509617 192.397251744374 1.02758396406624 0.0392562815885917 0.877280347823204 1 1.06421 1.16999 1.1154 1.07108 GeneID:55212,Genbank:NM_176824.2,HGNC:HGNC:18758,MIM:607590 Bardet-Biedl syndrome 7 BBS9 200.847972843237 195.256072384567 206.439873301906 1.05727760873584 0.0803542340164856 0.724760757703309 1 0.762225 0.704971 0.727413 0.808954 GeneID:27241,Genbank:XM_011515265.2,HGNC:HGNC:30000,MIM:607968 Bardet-Biedl syndrome 9 GO:0000242,GO:0005829,GO:0005929,GO:0007601,GO:0015031,GO:0016020,GO:0034451,GO:0034464,GO:0035869,GO:0045444,GO:0050896,GO:0060170,GO:0060271,GO:0061512 pericentriolar material|cytosol|cilium|visual perception|protein transport|membrane|centriolar satellite|BBSome|ciliary transition zone|fat cell differentiation|response to stimulus|ciliary membrane|cilium assembly|protein localization to cilium BBX 551.367474575611 552.567823334439 550.167125816783 0.995655379455198 -0.00628161804029315 0.995732107288155 1 2.02399 1.58284 2.25932 1.3682 GeneID:56987,Genbank:NM_001142568.2,HGNC:HGNC:14422 BBX, HMG-box containing GO:0003677,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0060348 DNA binding|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|bone development BCAM 1311.4456257532 1268.44509338026 1354.44615812614 1.06780038426156 0.0946419732873294 0.526589940173676 1 12.9268 12.5197 13.2304 14.9416 GeneID:4059,Genbank:NM_001013257.2,HGNC:HGNC:6722,MIM:612773 basal cell adhesion molecule (Lutheran blood group) BCAN 9.2545730053521 9.30154798208194 9.20759802862226 0.989899535685817 -0.014645980525938 1 1 0.0406525 0.00887174 0.0471849 0.0441332 GeneID:63827,Genbank:NM_021948.4,HGNC:HGNC:23059,MIM:600347 brevican BCAP29 992.195665039181 1080.51844071313 903.872889365228 0.836517781935013 -0.257531886797321 0.0997587949698939 1 5.21483 4.6486 4.55379 3.86739 GeneID:55973,Genbank:NM_018844.3,HGNC:HGNC:24131 B cell receptor associated protein 29 GO:0001649,GO:0005789,GO:0006886,GO:0006888,GO:0006915,GO:0016020,GO:0016021,GO:0070973 osteoblast differentiation|endoplasmic reticulum membrane|intracellular protein transport|ER to Golgi vesicle-mediated transport|apoptotic process|membrane|integral component of membrane|protein localization to endoplasmic reticulum exit site BCAP31 8208.89445000392 8107.85965954743 8309.92924046042 1.02492267865972 0.0355150752703835 0.822569509597947 1 154.176 165.529 163.671 178.159 GeneID:10134,Genbank:NM_001256447.1,HGNC:HGNC:16695,MIM:300398 B cell receptor associated protein 31 GO:0002474,GO:0005739,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0005887,GO:0006886,GO:0006888,GO:0007204,GO:0007283,GO:0016020,GO:0030136,GO:0032403,GO:0032471,GO:0032580,GO:0033116,GO:0035584,GO:0042288,GO:0043280,GO:0051561,GO:0070973,GO:0071556,GO:0097038,GO:0097194,GO:1903071,GO:1904154,GO:2001244 antigen processing and presentation of peptide antigen via MHC class I|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cytosol|integral component of plasma membrane|intracellular protein transport|ER to Golgi vesicle-mediated transport|positive regulation of cytosolic calcium ion concentration|spermatogenesis|membrane|clathrin-coated vesicle|protein complex binding|negative regulation of endoplasmic reticulum calcium ion concentration|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|calcium-mediated signaling using intracellular calcium source|MHC class I protein binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of mitochondrial calcium ion concentration|protein localization to endoplasmic reticulum exit site|integral component of lumenal side of endoplasmic reticulum membrane|perinuclear endoplasmic reticulum|execution phase of apoptosis|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of retrograde protein transport, ER to cytosol|positive regulation of intrinsic apoptotic signaling pathway hsa04141,hsa05165 Protein processing in endoplasmic reticulum|Human papillomavirus infection BCAR1 2032.6770858475 2078.87570103768 1986.47847065732 0.955554230426453 -0.0655903423050871 0.618783002141847 1 6.57944 7.25046 6.81831 6.7886 GeneID:9564,Genbank:NM_001170715.2,HGNC:HGNC:971,MIM:602941 BCAR1, Cas family scaffold protein hsa04015,hsa04062,hsa04510,hsa04670,hsa04810,hsa05100,hsa05163 Rap1 signaling pathway|Chemokine signaling pathway|Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Human cytomegalovirus infection BCAR3 1734.9747566388 1783.39512262528 1686.55439065231 0.945698667253045 -0.0805475313149154 0.566083558148526 1 12.4311 12.4643 12.6619 11.2116 GeneID:8412,Genbank:NM_001308251.1,HGNC:HGNC:973,MIM:604704 BCAR3, NSP family adaptor protein GO:0002089,GO:0005070,GO:0005085,GO:0005622,GO:0007165,GO:0007264,GO:0033138,GO:0042493 lens morphogenesis in camera-type eye|SH3/SH2 adaptor activity|guanyl-nucleotide exchange factor activity|intracellular|signal transduction|small GTPase mediated signal transduction|positive regulation of peptidyl-serine phosphorylation|response to drug BCAS1 0.974269732491135 0.980142803914724 0.968396661067546 0.988015886256305 -0.0173938558720137 1 1 0 0.00778294 0 0.0149013 GeneID:8537,Genbank:NM_001316361.2,HGNC:HGNC:974,MIM:602968 breast carcinoma amplified sequence 1 GO:0005737,GO:0070062 cytoplasm|extracellular exosome BCAS2 772.443835103681 847.979741161084 696.907929046278 0.821845022019096 -0.283061729014878 0.080593427035919 0.951623427935096 23.7307 22.6885 19.9427 18.6066 GeneID:10286,Genbank:NM_005872.2,HGNC:HGNC:975,MIM:605783 BCAS2, pre-mRNA processing factor GO:0000398,GO:0000974,GO:0005662,GO:0005681,GO:0005730,GO:0005813,GO:0016607,GO:0071011,GO:0071013 mRNA splicing, via spliceosome|Prp19 complex|DNA replication factor A complex|spliceosomal complex|nucleolus|centrosome|nuclear speck|precatalytic spliceosome|catalytic step 2 spliceosome hsa03040 Spliceosome BCAS3 285.588154026226 272.196265491018 298.980042561435 1.09839876760286 0.135401911902968 0.574032366670123 1 0.983885 1.11056 1.06987 1.34546 GeneID:54828,Genbank:NM_001353144.1,HGNC:HGNC:14347,MIM:607470 BCAS3, microtubule associated cell migration factor BCAS4 149.266295941209 177.873250597742 120.659341284676 0.678344500250606 -0.559909956366884 0.0283020071282109 0.668561867500627 1.89949 1.1688 1.00012 1.10824 GeneID:55653,Genbank:NM_017843.4,HGNC:HGNC:14367,MIM:607471 breast carcinoma amplified sequence 4 BCAT1 1304.32619664575 1428.50023471645 1180.15215857505 0.826147682649347 -0.275528393168494 0.133758807102888 1 4.848 4.12544 4.133 3.31956 GeneID:586,Genbank:NM_001178092.1,HGNC:HGNC:976,MIM:113520 branched chain amino acid transaminase 1 GO:0000082,GO:0004084,GO:0005739,GO:0005829,GO:0008283,GO:0009082,GO:0009083,GO:0009098,GO:0009099,GO:0042802,GO:0052654,GO:0052655,GO:0052656 G1/S transition of mitotic cell cycle|branched-chain-amino-acid transaminase activity|mitochondrion|cytosol|cell proliferation|branched-chain amino acid biosynthetic process|branched-chain amino acid catabolic process|leucine biosynthetic process|valine biosynthetic process|identical protein binding|L-leucine transaminase activity|L-valine transaminase activity|L-isoleucine transaminase activity hsa00270,hsa00280,hsa00290,hsa00770 Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation|Valine, leucine and isoleucine biosynthesis|Pantothenate and CoA biosynthesis BCAT2 1261.00001083186 1304.19087975783 1217.8091419059 0.933766031343534 -0.0988669878917527 0.498732302726267 1 20.8267 20.9821 19.3613 20.2671 GeneID:587,Genbank:NM_001164773.1,HGNC:HGNC:977,MIM:113530 branched chain amino acid transaminase 2 GO:0004084,GO:0005739,GO:0005759,GO:0006550,GO:0009082,GO:0009083,GO:0009098,GO:0009099,GO:0010817,GO:0052654,GO:0052655,GO:0052656,GO:1990830 branched-chain-amino-acid transaminase activity|mitochondrion|mitochondrial matrix|isoleucine catabolic process|branched-chain amino acid biosynthetic process|branched-chain amino acid catabolic process|leucine biosynthetic process|valine biosynthetic process|regulation of hormone levels|L-leucine transaminase activity|L-valine transaminase activity|L-isoleucine transaminase activity|cellular response to leukemia inhibitory factor hsa00270,hsa00280,hsa00290,hsa00770 Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation|Valine, leucine and isoleucine biosynthesis|Pantothenate and CoA biosynthesis BCCIP 1111.4702893022 1232.33268011373 990.607898490672 0.80384778759519 -0.31500574879541 0.0381171452230446 0.746313200357312 11.307 11.089 9.43266 8.4332 GeneID:56647,Genbank:NM_016567.3,HGNC:HGNC:978,MIM:611883 BRCA2 and CDKN1A interacting protein GO:0000079,GO:0000132,GO:0000226,GO:0003723,GO:0005634,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0006281,GO:0007052,GO:0015631,GO:0019207,GO:0019908,GO:0034453,GO:0061101,GO:0090307,GO:0097431 regulation of cyclin-dependent protein serine/threonine kinase activity|establishment of mitotic spindle orientation|microtubule cytoskeleton organization|RNA binding|nucleus|nucleoplasm|centrosome|centriole|cytosol|DNA repair|mitotic spindle organization|tubulin binding|kinase regulator activity|nuclear cyclin-dependent protein kinase holoenzyme complex|microtubule anchoring|neuroendocrine cell differentiation|mitotic spindle assembly|mitotic spindle pole BCDIN3D 176.55651837995 182.053570497042 171.059466262859 0.939610609096173 -0.089865092048077 0.701686369553468 1 2.09229 2.54037 2.05087 2.33925 GeneID:144233,Genbank:NM_181708.2,HGNC:HGNC:27050 BCDIN3 domain containing RNA methyltransferase GO:0001510,GO:0005634,GO:0005737,GO:0005829,GO:0008171,GO:0008173,GO:0010586,GO:2000632 RNA methylation|nucleus|cytoplasm|cytosol|O-methyltransferase activity|RNA methyltransferase activity|miRNA metabolic process|negative regulation of pre-miRNA processing BCHE 520.144897308622 523.635010309593 516.654784307652 0.986669672836019 -0.0193609292800962 0.972311637871112 1 8.48468 6.90289 8.82753 6.94212 GeneID:590,Genbank:NM_000055.3,HGNC:HGNC:983,MIM:177400 butyrylcholinesterase GO:0001540,GO:0003824,GO:0003990,GO:0004104,GO:0005576,GO:0005641,GO:0005788,GO:0007612,GO:0008285,GO:0014016,GO:0016020,GO:0016788,GO:0019695,GO:0019899,GO:0033265,GO:0042802,GO:0043279,GO:0050783,GO:0050805,GO:0051384,GO:0051593,GO:0072562 amyloid-beta binding|catalytic activity|acetylcholinesterase activity|cholinesterase activity|extracellular region|nuclear envelope lumen|endoplasmic reticulum lumen|learning|negative regulation of cell proliferation|neuroblast differentiation|membrane|hydrolase activity, acting on ester bonds|choline metabolic process|enzyme binding|choline binding|identical protein binding|response to alkaloid|cocaine metabolic process|negative regulation of synaptic transmission|response to glucocorticoid|response to folic acid|blood microparticle BCKDHA 1018.01905593652 982.989508072784 1053.04860380025 1.0712714582934 0.0993241027867138 0.537676243283867 1 20.5844 22.3361 22.567 24.2276 GeneID:593,Genbank:NM_000709.3,HGNC:HGNC:986,MIM:608348 branched chain keto acid dehydrogenase E1, alpha polypeptide GO:0003826,GO:0003863,GO:0005739,GO:0005759,GO:0005947,GO:0009083,GO:0016831,GO:0034641,GO:0046872 alpha-ketoacid dehydrogenase activity|3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|mitochondrion|mitochondrial matrix|mitochondrial alpha-ketoglutarate dehydrogenase complex|branched-chain amino acid catabolic process|carboxy-lyase activity|cellular nitrogen compound metabolic process|metal ion binding hsa00280,hsa00640 Valine, leucine and isoleucine degradation|Propanoate metabolism BCKDHB 420.47795538908 409.105432078189 431.85047869997 1.05559702912337 0.078059195455664 0.668593428158303 1 2.07639 1.90473 2.52638 1.76143 GeneID:594,Genbank:NM_183050.3,HGNC:HGNC:987,MIM:248611 branched chain keto acid dehydrogenase E1 subunit beta GO:0003826,GO:0003863,GO:0005739,GO:0005759,GO:0005947,GO:0009083,GO:0016831,GO:0034641 alpha-ketoacid dehydrogenase activity|3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|mitochondrion|mitochondrial matrix|mitochondrial alpha-ketoglutarate dehydrogenase complex|branched-chain amino acid catabolic process|carboxy-lyase activity|cellular nitrogen compound metabolic process hsa00280,hsa00640 Valine, leucine and isoleucine degradation|Propanoate metabolism BCKDK 1345.91399008099 1326.6381116985 1365.18986846349 1.02905973861676 0.041326735491863 0.794470890728927 1 21.7024 22.2861 23.3994 22.6951 GeneID:10295,Genbank:NM_001122957.2,HGNC:HGNC:16902,MIM:614901 branched chain ketoacid dehydrogenase kinase BCL10 391.39931220844 401.899456873739 380.899167543142 0.947747405547766 -0.0774254928541381 0.670461391310665 1 3.68106 3.95931 3.58216 3.77777 GeneID:8915,Genbank:NM_001320715.1,HGNC:HGNC:989,MIM:603517 B cell CLL/lymphoma 10 hsa04064,hsa04625,hsa04660,hsa04662,hsa05152 NF-kappa B signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Tuberculosis BCL11A 18.2118425412487 17.5269006108793 18.8967844716181 1.0781589335817 0.108569864351155 0.90444813172421 1 0.0822745 0.0712028 0.0671044 0.0729413 GeneID:53335,Genbank:NM_138559.1,HGNC:HGNC:13221,MIM:606557 B cell CLL/lymphoma 11A GO:0000122,GO:0000978,GO:0001078,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0006366,GO:0007165,GO:0010629,GO:0010976,GO:0010977,GO:0016604,GO:0016925,GO:0022008,GO:0030183,GO:0030217,GO:0043565,GO:0044212,GO:0046872,GO:0046982,GO:0048671,GO:0048672,GO:0050773,GO:2000171 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|transcription from RNA polymerase II promoter|signal transduction|negative regulation of gene expression|positive regulation of neuron projection development|negative regulation of neuron projection development|nuclear body|protein sumoylation|neurogenesis|B cell differentiation|T cell differentiation|sequence-specific DNA binding|transcription regulatory region DNA binding|metal ion binding|protein heterodimerization activity|negative regulation of collateral sprouting|positive regulation of collateral sprouting|regulation of dendrite development|negative regulation of dendrite development BCL2 92.7347106675754 89.5085447679639 95.9608765671869 1.07208621049476 0.100420923008726 0.769888740050926 1 0.343114 0.387655 0.422223 0.358104 GeneID:596,Genbank:NM_000633.2,HGNC:HGNC:990,MIM:151430 BCL2, apoptosis regulator hsa01521,hsa01522,hsa01524,hsa04064,hsa04066,hsa04071,hsa04115,hsa04140,hsa04141,hsa04151,hsa04210,hsa04215,hsa04217,hsa04261,hsa04340,hsa04510,hsa04621,hsa04630,hsa04722,hsa04725,hsa04915,hsa04928,hsa04933,hsa05014,hsa05145,hsa05152,hsa05161,hsa05169,hsa05170,hsa05200,hsa05206,hsa05210,hsa05215,hsa05222,hsa05226,hsa05418 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|NF-kappa B signaling pathway|HIF-1 signaling pathway|Sphingolipid signaling pathway|p53 signaling pathway|Autophagy - animal|Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Adrenergic signaling in cardiomyocytes|Hedgehog signaling pathway|Focal adhesion|NOD-like receptor signaling pathway|Jak-STAT signaling pathway|Neurotrophin signaling pathway|Cholinergic synapse|Estrogen signaling pathway|Parathyroid hormone synthesis, secretion and action|AGE-RAGE signaling pathway in diabetic complications|Amyotrophic lateral sclerosis (ALS)|Toxoplasmosis|Tuberculosis|Hepatitis B|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer|Prostate cancer|Small cell lung cancer|Gastric cancer|Fluid shear stress and atherosclerosis BCL2A1 1.26776669418146 1.56626675524197 0.969266633120943 0.61883879605885 -0.692364450254232 0.974556248291384 1 0.0842695 0.0396453 0.0402566 0 GeneID:597,Genbank:NM_004049.3,HGNC:HGNC:991,MIM:601056 BCL2 related protein A1 GO:0001836,GO:0005741,GO:0008053,GO:0008630,GO:0015267,GO:0042803,GO:0043065,GO:0043066,GO:0046982,GO:0097192 release of cytochrome c from mitochondria|mitochondrial outer membrane|mitochondrial fusion|intrinsic apoptotic signaling pathway in response to DNA damage|channel activity|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|protein heterodimerization activity|extrinsic apoptotic signaling pathway in absence of ligand hsa04064,hsa04210,hsa05202,hsa05221 NF-kappa B signaling pathway|Apoptosis|Transcriptional misregulation in cancer|Acute myeloid leukemia BCL2L1 6803.21741968722 6335.53121441075 7270.90362496368 1.14763914483214 0.198669082954363 0.137055758452849 1 71.6967 77.7929 90.1353 85.7466 GeneID:598,Genbank:NM_001317920.1,HGNC:HGNC:992,MIM:600039 BCL2 like 1 hsa01521,hsa01524,hsa04014,hsa04064,hsa04115,hsa04137,hsa04140,hsa04151,hsa04210,hsa04215,hsa04621,hsa04630,hsa05014,hsa05145,hsa05166,hsa05170,hsa05200,hsa05202,hsa05212,hsa05220,hsa05222,hsa05225 EGFR tyrosine kinase inhibitor resistance|Platinum drug resistance|Ras signaling pathway|NF-kappa B signaling pathway|p53 signaling pathway|Mitophagy - animal|Autophagy - animal|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|NOD-like receptor signaling pathway|Jak-STAT signaling pathway|Amyotrophic lateral sclerosis (ALS)|Toxoplasmosis|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Pancreatic cancer|Chronic myeloid leukemia|Small cell lung cancer|Hepatocellular carcinoma BCL2L10 1.24168699318059 1.02816907859967 1.45520490776151 1.41533619134263 0.501144783780499 1 1 0.0453953 0.0403259 0.125545 0 GeneID:10017,Genbank:NM_020396.3,HGNC:HGNC:993,MIM:606910 BCL2 like 10 GO:0005739,GO:0005741,GO:0005829,GO:0006919,GO:0007283,GO:0007292,GO:0008630,GO:0016020,GO:0016021,GO:0031965,GO:0042803,GO:0043066,GO:0046982,GO:0089720,GO:0097192,GO:2001243 mitochondrion|mitochondrial outer membrane|cytosol|activation of cysteine-type endopeptidase activity involved in apoptotic process|spermatogenesis|female gamete generation|intrinsic apoptotic signaling pathway in response to DNA damage|membrane|integral component of membrane|nuclear membrane|protein homodimerization activity|negative regulation of apoptotic process|protein heterodimerization activity|caspase binding|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway BCL2L11 288.670257505033 335.481085926709 241.859429083357 0.720933129256042 -0.472062647577738 0.0201478362533306 0.581419361141158 1.98231 1.95161 1.63118 1.19781 GeneID:10018,Genbank:NM_138624.3,HGNC:HGNC:994,MIM:603827 BCL2 like 11 GO:0001701,GO:0001776,GO:0001782,GO:0001783,GO:0001822,GO:0002260,GO:0002262,GO:0005737,GO:0005739,GO:0005829,GO:0006919,GO:0007160,GO:0007283,GO:0007420,GO:0008017,GO:0008584,GO:0008630,GO:0009791,GO:0019898,GO:0019901,GO:0030879,GO:0032464,GO:0034976,GO:0035148,GO:0042475,GO:0042981,GO:0043029,GO:0043065,GO:0043231,GO:0043280,GO:0043525,GO:0043583,GO:0045787,GO:0046620,GO:0046982,GO:0048066,GO:0048070,GO:0048536,GO:0048538,GO:0048563,GO:0060139,GO:0060154,GO:0070242,GO:0070840,GO:0090200,GO:0097136,GO:0097140,GO:0097141,GO:0097192,GO:1902110,GO:1902263,GO:2000271,GO:2001244 in utero embryonic development|leukocyte homeostasis|B cell homeostasis|B cell apoptotic process|kidney development|lymphocyte homeostasis|myeloid cell homeostasis|cytoplasm|mitochondrion|cytosol|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell-matrix adhesion|spermatogenesis|brain development|microtubule binding|male gonad development|intrinsic apoptotic signaling pathway in response to DNA damage|post-embryonic development|extrinsic component of membrane|protein kinase binding|mammary gland development|positive regulation of protein homooligomerization|response to endoplasmic reticulum stress|tube formation|odontogenesis of dentin-containing tooth|regulation of apoptotic process|T cell homeostasis|positive regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of neuron apoptotic process|ear development|positive regulation of cell cycle|regulation of organ growth|protein heterodimerization activity|developmental pigmentation|regulation of developmental pigmentation|spleen development|thymus development|post-embryonic animal organ morphogenesis|positive regulation of apoptotic process by virus|cellular process regulating host cell cycle in response to virus|thymocyte apoptotic process|dynein complex binding|positive regulation of release of cytochrome c from mitochondria|Bcl-2 family protein complex|BIM-BCL-xl complex|BIM-BCL-2 complex|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of mitochondrial membrane permeability involved in apoptotic process|apoptotic process involved in embryonic digit morphogenesis|positive regulation of fibroblast apoptotic process|positive regulation of intrinsic apoptotic signaling pathway hsa01521,hsa04068,hsa04151,hsa04210,hsa04215,hsa04932,hsa05169,hsa05200,hsa05206,hsa05210 EGFR tyrosine kinase inhibitor resistance|FoxO signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|Non-alcoholic fatty liver disease (NAFLD)|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Colorectal cancer BCL2L12 1255.66902750676 1320.17113092368 1191.16692408985 0.902282208865169 -0.148349355805405 0.308320468109048 1 12.5086 11.5009 10.8545 11.7776 GeneID:83596,Genbank:XM_017027346.2,HGNC:HGNC:13787,MIM:610837 BCL2 like 12 BCL2L13 2596.40610694361 2345.92908713399 2846.88312675323 1.21354185101616 0.27922386309336 0.0435571910251384 0.780326589998453 12.5897 13.2235 17.3788 14.3744 GeneID:23786,Genbank:XM_017028726.1,HGNC:HGNC:17164 BCL2 like 13 GO:0005634,GO:0005739,GO:0006915,GO:0006919,GO:0008656,GO:0016021,GO:0031966 nucleus|mitochondrion|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cysteine-type endopeptidase activator activity involved in apoptotic process|integral component of membrane|mitochondrial membrane hsa04137,hsa05134 Mitophagy - animal|Legionellosis BCL2L15 3.21510956755873 3.03648096111406 3.3937381740034 1.11765501495464 0.160474942188542 1 1 0.0206572 0.0397013 0.0497162 0.0185541 GeneID:440603,Genbank:NM_001010922.2,HGNC:HGNC:33624 BCL2 like 15 BCL2L2 850.30945431845 754.109597051044 946.509311585856 1.2551349502608 0.327842488961026 0.0358851715644605 0.738653561785664 10.0355 10.0502 13.2398 11.9765 GeneID:599,Genbank:NM_004050.4,HGNC:HGNC:995,MIM:601931 BCL2 like 2 GO:0005741,GO:0005829,GO:0008630,GO:0042803,GO:0046982,GO:0060011,GO:0097136,GO:0097192,GO:0097718,GO:2001243 mitochondrial outer membrane|cytosol|intrinsic apoptotic signaling pathway in response to DNA damage|protein homodimerization activity|protein heterodimerization activity|Sertoli cell proliferation|Bcl-2 family protein complex|extrinsic apoptotic signaling pathway in absence of ligand|disordered domain specific binding|negative regulation of intrinsic apoptotic signaling pathway hsa05206 MicroRNAs in cancer BCL3 337.334762372714 304.925188217683 369.744336527744 1.21257393883705 0.27807272085955 0.229791443761955 1 1.54167 1.74156 1.97538 2.16118 GeneID:602,Genbank:XM_011527198.3,HGNC:HGNC:998,MIM:109560 B cell CLL/lymphoma 3 GO:0000060,GO:0002268,GO:0002315,GO:0002455,GO:0002467,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0006974,GO:0007249,GO:0008134,GO:0009615,GO:0010225,GO:0019730,GO:0030198,GO:0030330,GO:0030496,GO:0030674,GO:0032729,GO:0032996,GO:0033257,GO:0042088,GO:0042345,GO:0042536,GO:0042742,GO:0042771,GO:0042832,GO:0042981,GO:0043066,GO:0043231,GO:0043234,GO:0045064,GO:0045082,GO:0045415,GO:0045727,GO:0045892,GO:0045893,GO:0045944,GO:0046426,GO:0048471,GO:0048536,GO:0051101,GO:0051457 protein import into nucleus, translocation|follicular dendritic cell differentiation|marginal zone B cell differentiation|humoral immune response mediated by circulating immunoglobulin|germinal center formation|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|cellular response to DNA damage stimulus|I-kappaB kinase/NF-kappaB signaling|transcription factor binding|response to virus|response to UV-C|antimicrobial humoral response|extracellular matrix organization|DNA damage response, signal transduction by p53 class mediator|midbody|protein binding, bridging|positive regulation of interferon-gamma production|Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|T-helper 1 type immune response|regulation of NF-kappaB import into nucleus|negative regulation of tumor necrosis factor biosynthetic process|defense response to bacterium|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|defense response to protozoan|regulation of apoptotic process|negative regulation of apoptotic process|intracellular membrane-bounded organelle|protein complex|T-helper 2 cell differentiation|positive regulation of interleukin-10 biosynthetic process|negative regulation of interleukin-8 biosynthetic process|positive regulation of translation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of JAK-STAT cascade|perinuclear region of cytoplasm|spleen development|regulation of DNA binding|maintenance of protein location in nucleus hsa04625,hsa04668 C-type lectin receptor signaling pathway|TNF signaling pathway BCL6 778.506876368376 730.212785215574 826.800967521179 1.13227402239621 0.179223148020606 0.270669830490702 1 2.68137 2.87203 3.47464 2.95949 GeneID:604,Genbank:NM_001706.4,HGNC:HGNC:1001,MIM:109565 B cell CLL/lymphoma 6 hsa04068,hsa05202 FoxO signaling pathway|Transcriptional misregulation in cancer BCL6B 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.013432 0 GeneID:255877,Genbank:NM_181844.3,HGNC:HGNC:1002,MIM:608992 B cell CLL/lymphoma 6B GO:0000977,GO:0001227,GO:0005634,GO:0042092,GO:0042127,GO:0045595,GO:0046872,GO:0050727 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|type 2 immune response|regulation of cell proliferation|regulation of cell differentiation|metal ion binding|regulation of inflammatory response BCL7A 221.447981877627 180.217746403051 262.678217352203 1.45756021587758 0.543555486412708 0.0127746225658875 0.46405612496835 2.02077 1.65293 2.87683 2.57645 GeneID:605,Genbank:NM_020993.4,HGNC:HGNC:1004,MIM:601406 BCL tumor suppressor 7A GO:0045892 negative regulation of transcription, DNA-templated BCL7B 1959.14655443402 1780.09787597967 2138.19523288837 1.20116722891522 0.264437019929083 0.0592078985656097 0.879410748501007 35.5147 32.427 42.159 41.1802 GeneID:9275,Genbank:NM_001197244.1,HGNC:HGNC:1005,MIM:605846 BCL tumor suppressor 7B BCL7C 877.730130549303 864.80688196276 890.653379135846 1.02988701606355 0.042486074975928 0.841252906589977 1 5.37872 5.51323 5.61789 6.42106 GeneID:9274,Genbank:NM_001286526.1,HGNC:HGNC:1006,MIM:605847 BCL tumor suppressor 7C GO:0006915 apoptotic process BCL9 925.560091171471 891.039397949286 960.080784393656 1.07748410070673 0.107666581146593 0.494566766431405 1 4.48063 4.70875 5.3124 4.74067 GeneID:607,Genbank:NM_004326.3,HGNC:HGNC:1008,MIM:602597 B cell CLL/lymphoma 9 BCL9L 2303.61959057742 2251.43358445219 2355.80559670264 1.04635802404797 0.0653765716056462 0.645816813950896 1 7.67119 7.34484 8.34292 7.70934 GeneID:283149,Genbank:NM_182557.2,HGNC:HGNC:23688,MIM:609004 B cell CLL/lymphoma 9 like GO:0003713,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0008013,GO:0010718,GO:0022604,GO:0030512,GO:0035019,GO:0035914,GO:0045944,GO:0060070,GO:1904837 transcription coactivator activity|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|beta-catenin binding|positive regulation of epithelial to mesenchymal transition|regulation of cell morphogenesis|negative regulation of transforming growth factor beta receptor signaling pathway|somatic stem cell population maintenance|skeletal muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly BCLAF1 904.189362811072 1016.39653929673 791.982186325417 0.779205906066358 -0.359923482379383 0.176606156185767 1 4.86404 4.1677 4.03609 2.93186 GeneID:9774,Genbank:NM_001077440.1,HGNC:HGNC:16863,MIM:612588 BCL2 associated transcription factor 1 BCLAF3 44.3243351564371 43.0870487518161 45.5616215610581 1.05743194024487 0.0805648097934114 0.87794261309318 1 0.158797 0.168383 0.205157 0.156101 GeneID:256643,Genbank:XM_011545475.2,HGNC:HGNC:27413 BCLAF1 and THRAP3 family member 3 GO:0005739 mitochondrion BCO1 10.6491355235281 7.24520982488261 14.0530612221736 1.93963481553155 0.955785054775902 0.288255328366371 1 0.0131775 0.0610853 0.137842 0.16347 GeneID:53630,Genbank:XM_017023287.2,HGNC:HGNC:13815,MIM:605748 beta-carotene oxygenase 1 GO:0001523,GO:0003834,GO:0005829,GO:0035238,GO:0042572,GO:0042574,GO:0046872,GO:1901810 retinoid metabolic process|beta-carotene 15,15'-monooxygenase activity|cytosol|vitamin A biosynthetic process|retinol metabolic process|retinal metabolic process|metal ion binding|beta-carotene metabolic process hsa00830 Retinol metabolism BCO2 23.303863126809 17.0368292089219 29.570897044696 1.73570426057979 0.795521153922124 0.200035487427741 1 0.112794 0.131283 0.398965 0.168093 GeneID:83875,Genbank:NM_031938.5,HGNC:HGNC:18503,MIM:611740 beta-carotene oxygenase 2 GO:0001523,GO:0005622,GO:0005739,GO:0005759,GO:0016116,GO:0016119,GO:0016121,GO:0016122,GO:0016702,GO:0042573,GO:0042574,GO:0046872,GO:0051881,GO:0055114,GO:0102076,GO:2000377 retinoid metabolic process|intracellular|mitochondrion|mitochondrial matrix|carotenoid metabolic process|carotene metabolic process|carotene catabolic process|xanthophyll metabolic process|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|retinoic acid metabolic process|retinal metabolic process|metal ion binding|regulation of mitochondrial membrane potential|oxidation-reduction process|beta,beta-carotene-9',10'-cleaving oxygenase activity|regulation of reactive oxygen species metabolic process BCOR 905.113537316549 939.815198425851 870.411876207248 0.926152160196121 -0.110678857420718 0.467676124416631 1 3.91372 4.10147 3.92887 3.55016 GeneID:54880,Genbank:XM_005272616.1,HGNC:HGNC:20893,MIM:300485 BCL6 corepressor GO:0000122,GO:0000415,GO:0000977,GO:0003714,GO:0005634,GO:0006351,GO:0007507,GO:0008134,GO:0030502,GO:0031072,GO:0035518,GO:0042476,GO:0042826,GO:0044212,GO:0045892,GO:0051572,GO:0060021,GO:0065001,GO:0070171 negative regulation of transcription from RNA polymerase II promoter|negative regulation of histone H3-K36 methylation|RNA polymerase II regulatory region sequence-specific DNA binding|transcription corepressor activity|nucleus|transcription, DNA-templated|heart development|transcription factor binding|negative regulation of bone mineralization|heat shock protein binding|histone H2A monoubiquitination|odontogenesis|histone deacetylase binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|negative regulation of histone H3-K4 methylation|palate development|specification of axis polarity|negative regulation of tooth mineralization BCORL1 385.636220306918 433.974612064176 337.297828549661 0.777229402764652 -0.36358761545101 0.0486230083505949 0.806708656465773 1.66743 1.85687 1.37484 1.38641 GeneID:63035,Genbank:XM_005262453.4,HGNC:HGNC:25657,MIM:300688 BCL6 corepressor like 1 GO:0005654,GO:0005886,GO:0006351,GO:0006355,GO:0016569 nucleoplasm|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|covalent chromatin modification BCR 1107.64260898384 1000.80456633177 1214.4806516359 1.21350430692709 0.279179228860965 0.0678561154628109 0.916343630061028 5.84208 6.3557 7.73593 7.34709 GeneID:613,Genbank:NM_004327.3,HGNC:HGNC:1014,MIM:151410 BCR, RhoGEF and GTPase activating protein hsa05200,hsa05220 Pathways in cancer|Chronic myeloid leukemia BCS1L 480.523088730382 517.621917318867 443.424260141897 0.856656654800684 -0.223211002181935 0.194061642504525 1 7.74195 8.77644 7.60311 7.82376 GeneID:617,Genbank:NM_001320717.1,HGNC:HGNC:1020,MIM:603647 BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone GO:0005524,GO:0005739,GO:0005750,GO:0007005,GO:0016021,GO:0032981,GO:0033617,GO:0034551 ATP binding|mitochondrion|mitochondrial respiratory chain complex III|mitochondrion organization|integral component of membrane|mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex IV assembly|mitochondrial respiratory chain complex III assembly BDH1 431.900909506609 426.699976273969 437.101842739249 1.02437747139363 0.0347474299475799 0.846955855684903 1 1.01253 0.915978 0.866168 1.13792 GeneID:622,Genbank:NM_203315.2,HGNC:HGNC:1027,MIM:603063 3-hydroxybutyrate dehydrogenase 1 GO:0003858,GO:0005654,GO:0005739,GO:0005759,GO:0046951,GO:0046952,GO:0099617 3-hydroxybutyrate dehydrogenase activity|nucleoplasm|mitochondrion|mitochondrial matrix|ketone body biosynthetic process|ketone body catabolic process|matrix side of mitochondrial inner membrane hsa00072,hsa00650 Synthesis and degradation of ketone bodies|Butanoate metabolism BDH2 187.986191792824 143.837809799475 232.134573786172 1.61386337924494 0.690518453195395 0.00283050909150854 0.197101885259134 1.0741 0.975182 1.91227 1.93057 GeneID:56898,Genbank:XM_006714274.3,HGNC:HGNC:32389 3-hydroxybutyrate dehydrogenase 2 GO:0003858,GO:0005737,GO:0005829,GO:0006635,GO:0016628,GO:0019290,GO:0030855,GO:0042168,GO:0046951,GO:0051287,GO:0055072,GO:0070062 3-hydroxybutyrate dehydrogenase activity|cytoplasm|cytosol|fatty acid beta-oxidation|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|siderophore biosynthetic process|epithelial cell differentiation|heme metabolic process|ketone body biosynthetic process|NAD binding|iron ion homeostasis|extracellular exosome hsa00072,hsa00650 Synthesis and degradation of ketone bodies|Butanoate metabolism BDKRB2 1.51824048055703 3.03648096111406 0 0 -Inf 0.221951500672507 1 0.0161985 0.0298938 0 0 GeneID:624,Genbank:NM_000623.3,HGNC:HGNC:1030,MIM:113503 bradykinin receptor B2 hsa04020,hsa04022,hsa04071,hsa04080,hsa04610,hsa04750,hsa04810,hsa04961,hsa05142,hsa05200 Calcium signaling pathway|cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Endocrine and other factor-regulated calcium reabsorption|Chagas disease (American trypanosomiasis)|Pathways in cancer BDNF 418.798123445262 398.007294622549 439.588952267976 1.104474611916 0.143360256462449 0.428919119449497 1 1.72563 1.71882 2.04559 1.67595 GeneID:627,Genbank:NM_170731.4,HGNC:HGNC:1033,MIM:113505 brain derived neurotrophic factor hsa04010,hsa04014,hsa04024,hsa04151,hsa04722,hsa05016,hsa05030,hsa05034 MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|Neurotrophin signaling pathway|Huntington disease|Cocaine addiction|Alcoholism BDP1 175.84897932469 178.641670992701 173.056287656678 0.968734151975932 -0.0458272912159636 0.941094378632199 1 0.4011 0.327598 0.459245 0.23881 GeneID:55814,Genbank:NM_018429.2,HGNC:HGNC:13652,MIM:607012 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB GO:0000126,GO:0001026,GO:0001156,GO:0003677,GO:0005654,GO:0070898 transcription factor TFIIIB complex|TFIIIB-type transcription factor activity|TFIIIC-class transcription factor binding|DNA binding|nucleoplasm|RNA polymerase III transcriptional preinitiation complex assembly BEAN1 58.1256545613298 51.8024727825708 64.4488363400888 1.24412663871469 0.315133343785916 0.412835355820752 1 0.15513 0.155073 0.171561 0.263404 GeneID:146227,Genbank:NM_001197224.3,HGNC:HGNC:24160,MIM:612051 brain expressed associated with NEDD4 1 GO:0016021 integral component of membrane BECN1 2105.00311829544 1913.40507196547 2296.6011646254 1.20026919457588 0.26335800760493 0.0598695814932987 0.879410748501007 22.2085 22.3607 27.0559 27.3334 GeneID:8678,Genbank:NM_001314000.1,HGNC:HGNC:1034,MIM:604378 beclin 1 GO:0000045,GO:0000407,GO:0000422,GO:0000423,GO:0000910,GO:0001666,GO:0005634,GO:0005768,GO:0005776,GO:0005783,GO:0005789,GO:0005802,GO:0005829,GO:0006914,GO:0006915,GO:0006968,GO:0006995,GO:0007040,GO:0007080,GO:0007568,GO:0008285,GO:0010008,GO:0010040,GO:0010288,GO:0010613,GO:0014068,GO:0016032,GO:0016236,GO:0016579,GO:0019898,GO:0019901,GO:0030425,GO:0031625,GO:0031966,GO:0032465,GO:0032801,GO:0033197,GO:0034198,GO:0034271,GO:0034272,GO:0035032,GO:0042149,GO:0042803,GO:0043066,GO:0043234,GO:0043548,GO:0043652,GO:0044804,GO:0045022,GO:0045324,GO:0045335,GO:0048666,GO:0050435,GO:0050790,GO:0051020,GO:0051607,GO:0060548,GO:0070301,GO:0071275,GO:0071280,GO:0071364,GO:0098780,GO:1902425,GO:1902902,GO:1905672,GO:2000378,GO:2000786 autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|mitophagy|cytokinesis|response to hypoxia|nucleus|endosome|autophagosome|endoplasmic reticulum|endoplasmic reticulum membrane|trans-Golgi network|cytosol|autophagy|apoptotic process|cellular defense response|cellular response to nitrogen starvation|lysosome organization|mitotic metaphase plate congression|aging|negative regulation of cell proliferation|endosome membrane|response to iron(II) ion|response to lead ion|positive regulation of cardiac muscle hypertrophy|positive regulation of phosphatidylinositol 3-kinase signaling|viral process|macroautophagy|protein deubiquitination|extrinsic component of membrane|protein kinase binding|dendrite|ubiquitin protein ligase binding|mitochondrial membrane|regulation of cytokinesis|receptor catabolic process|response to vitamin E|cellular response to amino acid starvation|phosphatidylinositol 3-kinase complex, class III, type I|phosphatidylinositol 3-kinase complex, class III, type II|phosphatidylinositol 3-kinase complex, class III|cellular response to glucose starvation|protein homodimerization activity|negative regulation of apoptotic process|protein complex|phosphatidylinositol 3-kinase binding|engulfment of apoptotic cell|autophagy of nucleus|early endosome to late endosome transport|late endosome to vacuole transport|phagocytic vesicle|neuron development|amyloid-beta metabolic process|regulation of catalytic activity|GTPase binding|defense response to virus|negative regulation of cell death|cellular response to hydrogen peroxide|cellular response to aluminum ion|cellular response to copper ion|cellular response to epidermal growth factor stimulus|response to mitochondrial depolarisation|positive regulation of attachment of mitotic spindle microtubules to kinetochore|negative regulation of autophagosome assembly|negative regulation of lysosome organization|negative regulation of reactive oxygen species metabolic process|positive regulation of autophagosome assembly hsa04136,hsa04137,hsa04140,hsa04215,hsa04371,hsa05167 Autophagy - other|Mitophagy - animal|Autophagy - animal|Apoptosis - multiple species|Apelin signaling pathway|Kaposi sarcoma-associated herpesvirus infection BEGAIN 59.873753025048 66.4369712563908 53.3105347937053 0.802422714123608 -0.317565650091705 0.41099452716874 1 0.415123 0.297402 0.29364 0.310811 GeneID:57596,Genbank:XM_011537031.1,HGNC:HGNC:24163 brain enriched guanylate kinase associated GO:0005737,GO:0016020 cytoplasm|membrane BEND3 224.452738183772 240.50532049806 208.400155869483 0.866509545143989 -0.206712453227191 0.347395319579635 1 1.4604 1.45115 1.33805 1.14645 GeneID:57673,Genbank:NM_001080450.2,HGNC:HGNC:23040,MIM:616374 BEN domain containing 3 GO:0000122,GO:0000182,GO:0000183,GO:0005654,GO:0005720,GO:0005730,GO:0006306,GO:0006351,GO:0034773,GO:0036124,GO:0043967,GO:0051260,GO:0080182,GO:0098532,GO:1903580 negative regulation of transcription from RNA polymerase II promoter|rDNA binding|chromatin silencing at rDNA|nucleoplasm|nuclear heterochromatin|nucleolus|DNA methylation|transcription, DNA-templated|histone H4-K20 trimethylation|histone H3-K9 trimethylation|histone H4 acetylation|protein homooligomerization|histone H3-K4 trimethylation|histone H3-K27 trimethylation|positive regulation of ATP metabolic process BEND5 43.619948827272 34.4196509957464 52.8202466587977 1.53459564901821 0.61785856959959 0.153698584356282 1 0.163098 0.151149 0.216748 0.187838 GeneID:79656,Genbank:NM_001349793.1,HGNC:HGNC:25668 BEN domain containing 5 GO:0003677,GO:0005794,GO:0006351,GO:0045892 DNA binding|Golgi apparatus|transcription, DNA-templated|negative regulation of transcription, DNA-templated BEND6 63.518218645552 77.112680894975 49.923756396129 0.647413056020236 -0.627241635015715 0.0859392011880044 0.964561165794104 0.375839 0.336031 0.29129 0.202568 GeneID:221336,Genbank:NM_152731.2,HGNC:HGNC:20871 BEN domain containing 6 GO:0001106,GO:0003682,GO:0005634,GO:0006351,GO:0045666,GO:0045746 RNA polymerase II transcription corepressor activity|chromatin binding|nucleus|transcription, DNA-templated|positive regulation of neuron differentiation|negative regulation of Notch signaling pathway BEND7 158.714004293863 158.943779365892 158.484229221835 0.997108725198996 -0.00417726954854155 0.983071698894704 1 0.592609 0.805604 0.807986 0.648364 GeneID:222389,Genbank:XM_011519392.2,HGNC:HGNC:23514 BEN domain containing 7 GO:0070062 extracellular exosome BEST1 16.6131880275556 12.8761266198383 20.3502494352728 1.58046360028171 0.660347808859758 0.353571836741805 1 0.0196816 0.035352 0.0738916 0.0979876 GeneID:7439,Genbank:XM_011545229.3,HGNC:HGNC:12703,MIM:607854 bestrophin 1 BEST2 1.2383154714421 0.538097676642304 1.93853326624189 3.60256761994999 1.84902550994227 0.680597935457111 1 0 0 0 0.056177 GeneID:54831,Genbank:XM_005259963.3,HGNC:HGNC:17107,MIM:607335 bestrophin 2 GO:0005254,GO:0005886,GO:0005929,GO:0007608,GO:0034707,GO:0051899 chloride channel activity|plasma membrane|cilium|sensory perception of smell|chloride channel complex|membrane depolarization hsa04970 Salivary secretion BEST3 19.1617725168457 17.9689457381517 20.3545992955398 1.13276536042529 0.179849054090442 0.817220519604686 1 0.0301385 0.0379166 0.0672394 0.0357983 GeneID:144453,Genbank:NM_001282614.1,HGNC:HGNC:17105,MIM:607337 bestrophin 3 GO:0005254,GO:0005886,GO:0034707,GO:0043271 chloride channel activity|plasma membrane|chloride channel complex|negative regulation of ion transport BEST4 1.46521110650189 1.96028560782945 0.97013660517434 0.494895540374107 -1.01480405310505 0.813633116358399 1 0 0.0367683 0.0129017 0 GeneID:266675,Genbank:XM_017001023.1,HGNC:HGNC:17106,MIM:607336 bestrophin 4 GO:0005254,GO:0005886,GO:0034707 chloride channel activity|plasma membrane|chloride channel complex BET1 503.513300855855 547.130028639077 459.896573072633 0.840561747664576 -0.250574291157781 0.156597262548249 1 21.045 19.3131 16.6321 17.0491 GeneID:10282,Genbank:NM_001317739.1,HGNC:HGNC:14562,MIM:605456 Bet1 golgi vesicular membrane trafficking protein GO:0000139,GO:0005789,GO:0005801,GO:0006888,GO:0015031,GO:0016020,GO:0016021,GO:0019905,GO:0030133,GO:0031201,GO:0031985,GO:0033116,GO:0048208,GO:0048280 Golgi membrane|endoplasmic reticulum membrane|cis-Golgi network|ER to Golgi vesicle-mediated transport|protein transport|membrane|integral component of membrane|syntaxin binding|transport vesicle|SNARE complex|Golgi cisterna|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating|vesicle fusion with Golgi apparatus hsa04130 SNARE interactions in vesicular transport BET1L 901.853831951735 910.132565315407 893.575098588063 0.981807631812838 -0.0264877137448791 0.866015785042157 1 13.67 13.6181 12.6823 14.6535 GeneID:51272,Genbank:NM_001098787.1,HGNC:HGNC:19348,MIM:615417 Bet1 golgi vesicular membrane trafficking protein like GO:0000139,GO:0005484,GO:0005768,GO:0005794,GO:0005829,GO:0006888,GO:0015031,GO:0016020,GO:0016021,GO:0031201,GO:0042147,GO:2000156 Golgi membrane|SNAP receptor activity|endosome|Golgi apparatus|cytosol|ER to Golgi vesicle-mediated transport|protein transport|membrane|integral component of membrane|SNARE complex|retrograde transport, endosome to Golgi|regulation of retrograde vesicle-mediated transport, Golgi to ER hsa04130 SNARE interactions in vesicular transport BEX1 355.114330604165 386.025066912363 324.203594295968 0.839851144613802 -0.251794447898083 0.18522192700102 1 18.2194 19.4141 15.407 16.1928 GeneID:55859,Genbank:NM_018476.3,HGNC:HGNC:1036,MIM:300690 brain expressed X-linked 1 BEX2 93.8962910578537 92.3333033201223 95.4592787955852 1.03385534106394 0.0480343352372308 0.871218962471833 1 2.94405 1.98461 2.10862 2.67922 GeneID:84707,Genbank:NM_032621.3,HGNC:HGNC:30933,MIM:300691 brain expressed X-linked 2 BEX3 2701.66189584942 2600.87680100713 2802.4469906917 1.07750086032776 0.107689021230938 0.437520769924552 1 57.9612 60.8508 63.5487 68.815 GeneID:27018,Genbank:NM_206915.2,HGNC:HGNC:13388,MIM:300361 brain expressed X-linked 3 GO:0005163,GO:0005634,GO:0005829,GO:0006919,GO:0007275,GO:0008625,GO:0008656,GO:0042802,GO:0043154,GO:0043281,GO:0046872 nerve growth factor receptor binding|nucleus|cytosol|activation of cysteine-type endopeptidase activity involved in apoptotic process|multicellular organism development|extrinsic apoptotic signaling pathway via death domain receptors|cysteine-type endopeptidase activator activity involved in apoptotic process|identical protein binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|metal ion binding hsa04722 Neurotrophin signaling pathway BEX4 25.1870011683017 26.6265348391135 23.7474674974898 0.89187224852877 -0.165091021079644 0.848249176908208 1 1.24135 0.614849 0.926095 0.791134 GeneID:56271,Genbank:NM_001080425.3,HGNC:HGNC:25475,MIM:300692 brain expressed X-linked 4 GO:0000922,GO:0005634,GO:0005737,GO:0005874,GO:0007059,GO:0030334,GO:0042127,GO:0042826,GO:0043014,GO:1904428 spindle pole|nucleus|cytoplasm|microtubule|chromosome segregation|regulation of cell migration|regulation of cell proliferation|histone deacetylase binding|alpha-tubulin binding|negative regulation of tubulin deacetylation BFAR 1494.21005664464 1489.4436103494 1498.97650293989 1.00640030446554 0.00920426378736613 0.953005981730591 1 18.0212 18.4734 19.3957 17.8565 GeneID:51283,Genbank:NM_016561.2,HGNC:HGNC:17613 bifunctional apoptosis regulator GO:0000209,GO:0005783,GO:0005887,GO:0006915,GO:0016020,GO:0030176,GO:0030674,GO:0042787,GO:0043066,GO:0043161,GO:0046872,GO:0051865,GO:0061630,GO:0070534,GO:0070936,GO:0089720,GO:1903895 protein polyubiquitination|endoplasmic reticulum|integral component of plasma membrane|apoptotic process|membrane|integral component of endoplasmic reticulum membrane|protein binding, bridging|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|caspase binding|negative regulation of IRE1-mediated unfolded protein response BFSP1 184.609531826973 160.327749677502 208.891313976444 1.30290180206875 0.381728354046466 0.136981761611735 1 0.972169 1.51365 1.85045 1.50558 GeneID:631,Genbank:NM_001278608.1,HGNC:HGNC:1040,MIM:603307 beaded filament structural protein 1 GO:0005200,GO:0005212,GO:0005882,GO:0005886,GO:0005938,GO:0048469,GO:0070307 structural constituent of cytoskeleton|structural constituent of eye lens|intermediate filament|plasma membrane|cell cortex|cell maturation|lens fiber cell development BGLAP 0.977641254229628 1.47021420587209 0.48506830258717 0.329930360249405 -1.59976655382621 0.793472162274683 1 0.547433 1.03363 0.201103 0.36774 GeneID:632,Genbank:NM_199173.5,HGNC:HGNC:1043,MIM:112260 bone gamma-carboxyglutamate protein hsa04928 Parathyroid hormone synthesis, secretion and action BGN 42.4027195521195 31.9791026410675 52.8263364631715 1.65190177648487 0.724127905406822 0.107136968359596 1 0.3962 0.587147 0.907598 0.669696 GeneID:633,Genbank:NM_001711.5,HGNC:HGNC:1044,MIM:301870 biglycan GO:0001974,GO:0004860,GO:0005201,GO:0005539,GO:0005576,GO:0005578,GO:0005737,GO:0005796,GO:0006469,GO:0009986,GO:0019221,GO:0019800,GO:0030133,GO:0030198,GO:0030203,GO:0030206,GO:0030207,GO:0030208,GO:0031012,GO:0042383,GO:0043202,GO:0046426,GO:0050840,GO:0070062 blood vessel remodeling|protein kinase inhibitor activity|extracellular matrix structural constituent|glycosaminoglycan binding|extracellular region|proteinaceous extracellular matrix|cytoplasm|Golgi lumen|negative regulation of protein kinase activity|cell surface|cytokine-mediated signaling pathway|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|transport vesicle|extracellular matrix organization|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|extracellular matrix|sarcolemma|lysosomal lumen|negative regulation of JAK-STAT cascade|extracellular matrix binding|extracellular exosome BHLHA15 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0863679 0 0 GeneID:168620,Genbank:NM_177455.3,HGNC:HGNC:22265,MIM:608606 basic helix-loop-helix family member a15 GO:0000977,GO:0001228,GO:0005634,GO:0006851,GO:0007030,GO:0007186,GO:0007267,GO:0010832,GO:0019722,GO:0030968,GO:0042149,GO:0042593,GO:0042803,GO:0048312,GO:0048469 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|mitochondrial calcium ion transmembrane transport|Golgi organization|G-protein coupled receptor signaling pathway|cell-cell signaling|negative regulation of myotube differentiation|calcium-mediated signaling|endoplasmic reticulum unfolded protein response|cellular response to glucose starvation|glucose homeostasis|protein homodimerization activity|intracellular distribution of mitochondria|cell maturation hsa04950 Maturity onset diabetes of the young BHLHE40 2685.83439209779 2560.5262329115 2811.14255128408 1.09787687981919 0.134716273984568 0.319570933018793 1 33.4257 31.0345 33.6134 36.6637 GeneID:8553,Genbank:NM_003670.2,HGNC:HGNC:1046,MIM:604256 basic helix-loop-helix family member e40 GO:0000122,GO:0000981,GO:0001078,GO:0001102,GO:0001191,GO:0003700,GO:0003705,GO:0003714,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0016604,GO:0019904,GO:0032922,GO:0042803,GO:0043153,GO:0043425,GO:0043426,GO:0043433,GO:0045892,GO:0046982,GO:0070888 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|transcriptional repressor activity, RNA polymerase II transcription factor binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|transcription corepressor activity|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear body|protein domain specific binding|circadian regulation of gene expression|protein homodimerization activity|entrainment of circadian clock by photoperiod|bHLH transcription factor binding|MRF binding|negative regulation of DNA binding transcription factor activity|negative regulation of transcription, DNA-templated|protein heterodimerization activity|E-box binding hsa04710 Circadian rhythm BHLHE41 396.144260065501 396.316566353468 395.971953777534 0.999130461340274 -0.00125502483766617 0.990387084623592 1 4.3044 4.7306 5.14787 4.08235 GeneID:79365,Genbank:NM_030762.2,HGNC:HGNC:16617,MIM:606200 basic helix-loop-helix family member e41 GO:0000122,GO:0000978,GO:0001078,GO:0001102,GO:0001191,GO:0003705,GO:0003714,GO:0005634,GO:0006351,GO:0008283,GO:0009887,GO:0010832,GO:0010944,GO:0030154,GO:0032922,GO:0042803,GO:0042826,GO:0043425,GO:0043426,GO:0045892,GO:0046982,GO:0070888 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|transcriptional repressor activity, RNA polymerase II transcription factor binding|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|transcription corepressor activity|nucleus|transcription, DNA-templated|cell proliferation|animal organ morphogenesis|negative regulation of myotube differentiation|negative regulation of transcription by competitive promoter binding|cell differentiation|circadian regulation of gene expression|protein homodimerization activity|histone deacetylase binding|bHLH transcription factor binding|MRF binding|negative regulation of transcription, DNA-templated|protein heterodimerization activity|E-box binding hsa04710 Circadian rhythm BHMG1 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0.0118244 0.0104781 0 0.0103154 GeneID:388553,Genbank:NM_001310124.1,HGNC:HGNC:44318 basic helix-loop-helix and HMG-box containing 1 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046983 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|protein dimerization activity BHMT 0.968396661067546 0 1.93679332213509 Inf Inf 0.496080204589898 1 0 0 0 0 GeneID:635,Genbank:NM_001713.2,HGNC:HGNC:1047,MIM:602888 betaine--homocysteine S-methyltransferase GO:0000096,GO:0005829,GO:0006479,GO:0006577,GO:0006579,GO:0008270,GO:0042426,GO:0047150,GO:0050666,GO:0070062,GO:0071267 sulfur amino acid metabolic process|cytosol|protein methylation|amino-acid betaine metabolic process|amino-acid betaine catabolic process|zinc ion binding|choline catabolic process|betaine-homocysteine S-methyltransferase activity|regulation of homocysteine metabolic process|extracellular exosome|L-methionine salvage hsa00260,hsa00270 Glycine, serine and threonine metabolism|Cysteine and methionine metabolism BICC1 255.983045747327 283.658995833922 228.307095660732 0.80486464033879 -0.313181919277583 0.372229159824741 1 0.71368 0.612764 0.656442 0.392668 GeneID:80114,Genbank:XM_024448175.1,HGNC:HGNC:19351,MIM:614295 BicC family RNA binding protein 1 GO:0003723,GO:0005737,GO:0007368,GO:0007507,GO:0090090 RNA binding|cytoplasm|determination of left/right symmetry|heart development|negative regulation of canonical Wnt signaling pathway BICD1 875.93201722854 829.578558950768 922.285475506313 1.11175182332677 0.15283477078102 0.316013980674565 1 2.3889 2.14007 2.72291 2.33315 GeneID:636,Genbank:XM_011520814.3,HGNC:HGNC:1049,MIM:602204 BICD cargo adaptor 1 GO:0005200,GO:0005794,GO:0005802,GO:0005813,GO:0005829,GO:0005856,GO:0006396,GO:0008093,GO:0008298,GO:0009653,GO:0016020,GO:0016032,GO:0017137,GO:0019901,GO:0031410,GO:0031871,GO:0033365,GO:0034063,GO:0034452,GO:0045505,GO:0048260,GO:0048471,GO:0070507,GO:0070840,GO:0072385,GO:0072393,GO:0072517,GO:1900275,GO:1900276,GO:1900737,GO:1904781 structural constituent of cytoskeleton|Golgi apparatus|trans-Golgi network|centrosome|cytosol|cytoskeleton|RNA processing|cytoskeletal adaptor activity|intracellular mRNA localization|anatomical structure morphogenesis|membrane|viral process|Rab GTPase binding|protein kinase binding|cytoplasmic vesicle|proteinase activated receptor binding|protein localization to organelle|stress granule assembly|dynactin binding|dynein intermediate chain binding|positive regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|regulation of microtubule cytoskeleton organization|dynein complex binding|minus-end-directed organelle transport along microtubule|microtubule anchoring at microtubule organizing center|host cell viral assembly compartment|negative regulation of phospholipase C activity|regulation of proteinase activated receptor activity|negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of protein localization to centrosome BICD2 1163.06747520327 1001.71604854993 1324.41890185662 1.3221500282179 0.402885892946341 0.00693757074933783 0.331661688677574 6.33446 6.01499 7.99883 8.53056 GeneID:23299,Genbank:XM_017014551.1,HGNC:HGNC:17208,MIM:609797 BICD cargo adaptor 2 GO:0000042,GO:0005635,GO:0005642,GO:0005643,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005886,GO:0006890,GO:0008093,GO:0017137,GO:0031410,GO:0034452,GO:0051028,GO:0051642,GO:0051959,GO:0070507,GO:0070840,GO:0072385,GO:0072393 protein targeting to Golgi|nuclear envelope|annulate lamellae|nuclear pore|cytoplasm|Golgi apparatus|centrosome|cytosol|plasma membrane|retrograde vesicle-mediated transport, Golgi to ER|cytoskeletal adaptor activity|Rab GTPase binding|cytoplasmic vesicle|dynactin binding|mRNA transport|centrosome localization|dynein light intermediate chain binding|regulation of microtubule cytoskeleton organization|dynein complex binding|minus-end-directed organelle transport along microtubule|microtubule anchoring at microtubule organizing center BICDL1 40.416502848475 43.5192852239806 37.3137204729694 0.857406556218168 -0.221948646023502 0.663380724802115 1 0.329369 0.153178 0.178439 0.315978 GeneID:92558,Genbank:XM_011539001.2,HGNC:HGNC:28095,MIM:617002 BICD family like cargo adaptor 1 GO:0005737,GO:0005813,GO:0017137,GO:0031175,GO:0034452,GO:0055107 cytoplasm|centrosome|Rab GTPase binding|neuron projection development|dynactin binding|Golgi to secretory granule transport BICDL2 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0 0 0 0 GeneID:146439,Genbank:XM_005255135.4,HGNC:HGNC:33584,MIM:617003 BICD family like cargo adaptor 2 GO:0017137 Rab GTPase binding BICRA 316.224824700041 271.850272913115 360.599376486966 1.32646317630226 0.407584625733578 0.0399403997735306 0.758464027333929 1.72652 1.65739 2.55283 1.96899 GeneID:29998,Genbank:NM_015711.3,HGNC:HGNC:4332,MIM:605690 BRD4 interacting chromatin remodeling complex associated protein BICRAL 364.346832722911 387.495281118235 341.198384327586 0.880522682348427 -0.183567926390101 0.330212677983308 1 2.1904 2.3083 2.21834 1.86359 GeneID:23506,Genbank:NM_001318819.1,HGNC:HGNC:21111 BRD4 interacting chromatin remodeling complex associated protein like BID 873.281921051963 911.564561901702 834.999280202224 0.916006737317927 -0.126569885364906 0.409612930929575 1 11.9762 12.4076 11.1414 10.6171 GeneID:637,Genbank:NM_001244567.1,HGNC:HGNC:1050,MIM:601997 BH3 interacting domain death agonist hsa01524,hsa04071,hsa04115,hsa04210,hsa04215,hsa04217,hsa04650,hsa04932,hsa05010,hsa05014,hsa05152,hsa05163,hsa05167,hsa05169,hsa05170,hsa05200,hsa05416 Platinum drug resistance|Sphingolipid signaling pathway|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Natural killer cell mediated cytotoxicity|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral myocarditis BIK 15.1339924833053 16.2105738841699 14.0574110824406 0.867175411733448 -0.205604244414589 0.798622504060474 1 0.662618 0.949931 1.05188 0.637996 GeneID:638,Genbank:NM_001197.4,HGNC:HGNC:1051,MIM:603392 BCL2 interacting killer hsa01522 Endocrine resistance BIN1 866.52916552372 909.633702259197 823.424628788243 0.905226605767968 -0.14364910700657 0.342797577739012 1 4.3574 5.12942 4.91226 4.18936 GeneID:274,Genbank:NM_139351.2,HGNC:HGNC:1052,MIM:601248 bridging integrator 1 hsa04144,hsa04666 Endocytosis|Fc gamma R-mediated phagocytosis BIN3 618.510666767239 577.918283068129 659.103050466348 1.14047793568187 0.189638535742315 0.259905915497961 1 4.24905 4.66182 5.45483 5.0068 GeneID:55909,Genbank:NM_018688.4,HGNC:HGNC:1054,MIM:606396 bridging integrator 3 GO:0000910,GO:0000917,GO:0005737,GO:0005884,GO:0007015,GO:0008093,GO:0008104,GO:0009826,GO:0010591,GO:0014839,GO:0048741 cytokinesis|division septum assembly|cytoplasm|actin filament|actin filament organization|cytoskeletal adaptor activity|protein localization|unidimensional cell growth|regulation of lamellipodium assembly|myoblast migration involved in skeletal muscle regeneration|skeletal muscle fiber development BIRC2 415.035431394972 446.65761658442 383.413246205525 0.858405257112767 -0.220269183299808 0.454980543370711 1 4.49516 4.1348 4.40227 2.67565 GeneID:329,Genbank:NM_001166.4,HGNC:HGNC:590,MIM:601712 baculoviral IAP repeat containing 2 hsa01524,hsa04064,hsa04120,hsa04210,hsa04215,hsa04217,hsa04390,hsa04510,hsa04621,hsa04668,hsa05145,hsa05200,hsa05222 Platinum drug resistance|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Apoptosis|Apoptosis - multiple species|Necroptosis|Hippo signaling pathway|Focal adhesion|NOD-like receptor signaling pathway|TNF signaling pathway|Toxoplasmosis|Pathways in cancer|Small cell lung cancer BIRC3 81.4407825928453 118.287470313647 44.5940948720439 0.376997620743769 -1.40737267630588 2.24900190293431e-05 0.00847369839142897 0.689615 0.658371 0.318996 0.193947 GeneID:330,Genbank:XM_024448467.1,HGNC:HGNC:591,MIM:601721 baculoviral IAP repeat containing 3 hsa01524,hsa04064,hsa04120,hsa04210,hsa04215,hsa04217,hsa04510,hsa04621,hsa04668,hsa05145,hsa05200,hsa05202,hsa05222 Platinum drug resistance|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Apoptosis|Apoptosis - multiple species|Necroptosis|Focal adhesion|NOD-like receptor signaling pathway|TNF signaling pathway|Toxoplasmosis|Pathways in cancer|Transcriptional misregulation in cancer|Small cell lung cancer BIRC5 4954.79243153723 4629.27514764321 5280.30971543125 1.14063423473964 0.189836239194891 0.157138307768194 1 73.4685 78.4383 83.4166 89.436 GeneID:332,Genbank:NM_001012271.1,HGNC:HGNC:593,MIM:603352 baculoviral IAP repeat containing 5 GO:0000086,GO:0000775,GO:0000777,GO:0000910,GO:0005634,GO:0005737,GO:0005814,GO:0005829,GO:0005876,GO:0005881,GO:0006351,GO:0006468,GO:0007059,GO:0008017,GO:0008270,GO:0015631,GO:0030496,GO:0031021,GO:0031503,GO:0031536,GO:0031577,GO:0032133,GO:0042803,GO:0043027,GO:0043066,GO:0043154,GO:0045892,GO:0045931,GO:0048037,GO:0051301,GO:0051303 G2/M transition of mitotic cell cycle|chromosome, centromeric region|condensed chromosome kinetochore|cytokinesis|nucleus|cytoplasm|centriole|cytosol|spindle microtubule|cytoplasmic microtubule|transcription, DNA-templated|protein phosphorylation|chromosome segregation|microtubule binding|zinc ion binding|tubulin binding|midbody|interphase microtubule organizing center|protein complex localization|positive regulation of exit from mitosis|spindle checkpoint|chromosome passenger complex|protein homodimerization activity|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle|cofactor binding|cell division|establishment of chromosome localization hsa01524,hsa04210,hsa04215,hsa04390,hsa05161,hsa05200,hsa05210 Platinum drug resistance|Apoptosis|Apoptosis - multiple species|Hippo signaling pathway|Hepatitis B|Pathways in cancer|Colorectal cancer BIRC6 537.203944963111 566.356449173291 508.051440752932 0.897052450792313 -0.156735752679633 0.791711765719808 1 1.23015 0.869495 1.32037 0.609711 GeneID:57448,Genbank:XM_005264454.5,HGNC:HGNC:13516,MIM:605638 baculoviral IAP repeat containing 6 hsa04120,hsa04215 Ubiquitin mediated proteolysis|Apoptosis - multiple species BIVM 89.0412422252676 83.5698530146826 94.5126314358526 1.13094169759096 0.177524557299051 0.563523791640892 1 2.02231 1.70524 2.17699 1.65047 GeneID:54841,Genbank:NM_017693.3,HGNC:HGNC:16034 basic, immunoglobulin-like variable motif containing GO:0005615,GO:0005634,GO:0005737 extracellular space|nucleus|cytoplasm BLCAP 1159.24051846736 1164.10013638463 1154.38090055008 0.991650859293998 -0.0120958293425111 0.932984445176875 1 18.9553 18.7624 19.3997 18.839 GeneID:10904,Genbank:NM_006698.3,HGNC:HGNC:1055,MIM:613110 bladder cancer associated protein GO:0007049,GO:0016021,GO:0030262 cell cycle|integral component of membrane|apoptotic nuclear changes BLID 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:414899,Genbank:NM_001001786.2,HGNC:HGNC:33495,MIM:608853 BH3-like motif containing, cell death inducer GO:0005739,GO:0005829,GO:0006915,GO:0043280 mitochondrion|cytosol|apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process BLM 252.748132440705 279.142492011828 226.353772869582 0.81088970453123 -0.302422399368491 0.376844721259353 1 1.78329 1.42247 1.65906 0.999005 GeneID:641,Genbank:NM_001287246.1,HGNC:HGNC:1058,MIM:604610 Bloom syndrome RecQ like helicase hsa03440,hsa03460 Homologous recombination|Fanconi anemia pathway BLMH 1585.07012965622 1563.07878215684 1607.06147715559 1.02813850171906 0.040034624730172 0.795401260470361 1 20.1438 22.342 23.0927 20.9072 GeneID:642,Genbank:NM_000386.3,HGNC:HGNC:1059,MIM:602403 bleomycin hydrolase GO:0000209,GO:0004177,GO:0004180,GO:0004197,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008234,GO:0009636,GO:0042493,GO:0042802,GO:0043418,GO:0070062 protein polyubiquitination|aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|nucleus|cytoplasm|cytosol|proteolysis|cysteine-type peptidase activity|response to toxic substance|response to drug|identical protein binding|homocysteine catabolic process|extracellular exosome BLNK 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0.00765216 0.00727606 0 0.0068238 GeneID:29760,Genbank:XM_017016159.1,HGNC:HGNC:14211,MIM:604515 B cell linker hsa04064,hsa04380,hsa04662,hsa05169,hsa05340 NF-kappa B signaling pathway|Osteoclast differentiation|B cell receptor signaling pathway|Epstein-Barr virus infection|Primary immunodeficiency BLOC1S1 831.774230123744 844.589492968669 818.958967278818 0.969653274279127 -0.0444591299596454 0.766002670816732 1 50.5866 53.3429 46.3123 53.0482 GeneID:2647,Genbank:NM_001487.3,HGNC:HGNC:4200,MIM:601444 biogenesis of lysosomal organelles complex 1 subunit 1 GO:0005615,GO:0005758,GO:0005759,GO:0005765,GO:0005829,GO:0008089,GO:0009060,GO:0016197,GO:0018394,GO:0031083,GO:0031175,GO:0032418,GO:0032438,GO:0048490,GO:0060155,GO:0070062,GO:0099078,GO:1904115 extracellular space|mitochondrial intermembrane space|mitochondrial matrix|lysosomal membrane|cytosol|anterograde axonal transport|aerobic respiration|endosomal transport|peptidyl-lysine acetylation|BLOC-1 complex|neuron projection development|lysosome localization|melanosome organization|anterograde synaptic vesicle transport|platelet dense granule organization|extracellular exosome|BORC complex|axon cytoplasm BLOC1S2 812.710054890718 833.980409914131 791.439699867306 0.948990756208284 -0.0755340603674461 0.634027787404081 1 6.75794 6.94296 6.87135 6.14906 GeneID:282991,Genbank:NM_001282439.1,HGNC:HGNC:20984,MIM:609768 biogenesis of lysosomal organelles complex 1 subunit 2 GO:0000930,GO:0005739,GO:0005765,GO:0008089,GO:0008625,GO:0031083,GO:0031175,GO:0032418,GO:0043015,GO:0048490,GO:0097345,GO:0099078,GO:1904115 gamma-tubulin complex|mitochondrion|lysosomal membrane|anterograde axonal transport|extrinsic apoptotic signaling pathway via death domain receptors|BLOC-1 complex|neuron projection development|lysosome localization|gamma-tubulin binding|anterograde synaptic vesicle transport|mitochondrial outer membrane permeabilization|BORC complex|axon cytoplasm BLOC1S3 343.734968014556 315.763576989683 371.706359039428 1.17716667192294 0.235318602222623 0.223901269213042 1 7.03033 7.06428 8.51905 8.43352 GeneID:388552,Genbank:NM_212550.4,HGNC:HGNC:20914,MIM:609762 biogenesis of lysosomal organelles complex 1 subunit 3 GO:0001654,GO:0005829,GO:0008089,GO:0030133,GO:0030168,GO:0031083,GO:0031175,GO:0032402,GO:0032438,GO:0035646,GO:0043473,GO:0048490,GO:0060155,GO:1904115 eye development|cytosol|anterograde axonal transport|transport vesicle|platelet activation|BLOC-1 complex|neuron projection development|melanosome transport|melanosome organization|endosome to melanosome transport|pigmentation|anterograde synaptic vesicle transport|platelet dense granule organization|axon cytoplasm BLOC1S4 399.189421286548 402.927625952338 395.451216620757 0.981444783504457 -0.0270209915414296 0.878407622674033 1 15.1696 15.9207 15.7382 15.4165 GeneID:55330,Genbank:NM_018366.2,HGNC:HGNC:24206,MIM:605695 biogenesis of lysosomal organelles complex 1 subunit 4 GO:0005737,GO:0005829,GO:0008089,GO:0031083,GO:0031175,GO:0032438,GO:0046907,GO:0048490,GO:0050885,GO:0070527,GO:1904115 cytoplasm|cytosol|anterograde axonal transport|BLOC-1 complex|neuron projection development|melanosome organization|intracellular transport|anterograde synaptic vesicle transport|neuromuscular process controlling balance|platelet aggregation|axon cytoplasm BLOC1S5 309.996452425879 332.617092754119 287.375812097639 0.863983897273963 -0.210923670854506 0.307102580848818 1 4.47145 3.51711 3.43335 3.42939 GeneID:63915,Genbank:NM_001199323.1,HGNC:HGNC:18561,MIM:607289 biogenesis of lysosomal organelles complex 1 subunit 5 GO:0008089,GO:0030133,GO:0031083,GO:0031175,GO:0032402,GO:0032438,GO:0035646,GO:0048490,GO:0050942,GO:1904115 anterograde axonal transport|transport vesicle|BLOC-1 complex|neuron projection development|melanosome transport|melanosome organization|endosome to melanosome transport|anterograde synaptic vesicle transport|positive regulation of pigment cell differentiation|axon cytoplasm BLOC1S6 752.470897054714 706.73636719545 798.205426913978 1.12942458314619 0.175587938589733 0.262928771350513 1 7.11536 6.96324 8.33562 7.65277 GeneID:26258,Genbank:NM_012388.3,HGNC:HGNC:8549,MIM:604310 biogenesis of lysosomal organelles complex 1 subunit 6 GO:0005737,GO:0005829,GO:0008089,GO:0016081,GO:0019898,GO:0019905,GO:0030133,GO:0031083,GO:0031175,GO:0032402,GO:0032438,GO:0035646,GO:0042802,GO:0042803,GO:0048490,GO:0050942,GO:0051015,GO:0098793,GO:1904115 cytoplasm|cytosol|anterograde axonal transport|synaptic vesicle docking|extrinsic component of membrane|syntaxin binding|transport vesicle|BLOC-1 complex|neuron projection development|melanosome transport|melanosome organization|endosome to melanosome transport|identical protein binding|protein homodimerization activity|anterograde synaptic vesicle transport|positive regulation of pigment cell differentiation|actin filament binding|presynapse|axon cytoplasm BLVRA 866.276990935971 857.340141073814 875.213840798129 1.02084785124132 0.0297678607147858 0.855154223602627 1 23.1019 22.9529 24.0851 24.1516 GeneID:644,Genbank:XM_011515474.3,HGNC:HGNC:1062,MIM:109750 biliverdin reductase A hsa00860 Porphyrin and chlorophyll metabolism BLVRB 1257.06925371142 1116.12319926921 1398.01530815364 1.25256361400696 0.324883875501778 0.134428123327438 1 51.0666 54.6557 60.6261 73.7351 GeneID:645,Genbank:NM_000713.2,HGNC:HGNC:1063,MIM:600941 biliverdin reductase B hsa00740,hsa00860 Riboflavin metabolism|Porphyrin and chlorophyll metabolism BLZF1 193.154725609681 181.27432444612 205.035126773242 1.13107649083632 0.177696497160406 0.644700832814881 1 2.01987 1.4528 2.45866 1.48913 GeneID:8548,Genbank:NM_003666.3,HGNC:HGNC:1065,MIM:608692 basic leucine zipper nuclear factor 1 GO:0000139,GO:0001558,GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0005794,GO:0005796,GO:0006357,GO:0007030,GO:0008283,GO:0019899,GO:0031625,GO:0043001 Golgi membrane|regulation of cell growth|DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|Golgi apparatus|Golgi lumen|regulation of transcription from RNA polymerase II promoter|Golgi organization|cell proliferation|enzyme binding|ubiquitin protein ligase binding|Golgi to plasma membrane protein transport BMF 51.0722955498587 55.6171827937519 46.5274083059655 0.836565355683431 -0.257449841369458 0.543307058697233 1 0.452245 0.369608 0.409701 0.31614 GeneID:90427,Genbank:NM_001003943.2,HGNC:HGNC:24132,MIM:606266 Bcl2 modifying factor GO:0001669,GO:0001844,GO:0005741,GO:0005829,GO:0005886,GO:0010507,GO:0016459,GO:0032464,GO:0034644,GO:0043065,GO:0043276,GO:0090200,GO:1900740,GO:2001244 acrosomal vesicle|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|mitochondrial outer membrane|cytosol|plasma membrane|negative regulation of autophagy|myosin complex|positive regulation of protein homooligomerization|cellular response to UV|positive regulation of apoptotic process|anoikis|positive regulation of release of cytochrome c from mitochondria|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway hsa05206 MicroRNAs in cancer BMI1 32.6864783811302 38.2343610069274 27.138595755333 0.709795980385704 -0.494523690527996 0.337868660798956 1 11.4179 10.8135 12.4367 9.93824 GeneID:648,Genbank:NM_005180.8,HGNC:HGNC:1066,MIM:164831 BMI1 proto-oncogene, polycomb ring finger hsa04550,hsa05202,hsa05206 Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer|MicroRNAs in cancer BMP1 2553.78394226739 2833.77536979561 2273.79251473916 0.80238982206383 -0.317624788726858 0.0315217933633613 0.705022653979306 15.3843 17.109 12.7687 13.9676 GeneID:649,Genbank:NM_006129.4,HGNC:HGNC:1067,MIM:112264 bone morphogenetic protein 1 GO:0001501,GO:0001502,GO:0001503,GO:0004222,GO:0004252,GO:0005125,GO:0005509,GO:0005576,GO:0005578,GO:0005615,GO:0005794,GO:0006508,GO:0007275,GO:0008083,GO:0008233,GO:0008237,GO:0008270,GO:0022617,GO:0030154,GO:0031982,GO:0034380,GO:0042802,GO:0061036 skeletal system development|cartilage condensation|ossification|metalloendopeptidase activity|serine-type endopeptidase activity|cytokine activity|calcium ion binding|extracellular region|proteinaceous extracellular matrix|extracellular space|Golgi apparatus|proteolysis|multicellular organism development|growth factor activity|peptidase activity|metallopeptidase activity|zinc ion binding|extracellular matrix disassembly|cell differentiation|vesicle|high-density lipoprotein particle assembly|identical protein binding|positive regulation of cartilage development BMP2 4.33639465981648 4.7948528150958 3.87793650453717 0.808770707690574 -0.306197348678614 0.952415245632353 1 0.115623 0.0134121 0.0548114 0.0383581 GeneID:650,Genbank:NM_001200.3,HGNC:HGNC:1069,MIM:112261 bone morphogenetic protein 2 hsa04060,hsa04350,hsa04390,hsa05200,hsa05217 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Pathways in cancer|Basal cell carcinoma BMP2K 531.871336424577 596.021498975228 467.721173873925 0.784738763078352 -0.349715629337003 0.0417905810782898 0.763190360946282 2.42741 2.61218 2.33254 1.70043 GeneID:55589,Genbank:NM_198892.1,HGNC:HGNC:18041,MIM:617648 BMP2 inducible kinase GO:0004674,GO:0005524,GO:0005737,GO:0006468,GO:0016607,GO:0019208,GO:0030500,GO:0035612,GO:0045747,GO:2000369 protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation|nuclear speck|phosphatase regulator activity|regulation of bone mineralization|AP-2 adaptor complex binding|positive regulation of Notch signaling pathway|regulation of clathrin-dependent endocytosis hsa05202 Transcriptional misregulation in cancer BMP3 2.7801341033149 3.6226049124413 1.93766329418849 0.534881208694293 -0.902709574695096 0.715893962996954 1 0.0364159 0.0262862 0.0087552 0.0244891 GeneID:651,Genbank:XM_006714291.3,HGNC:HGNC:1070,MIM:112263 bone morphogenetic protein 3 hsa04060 Cytokine-cytokine receptor interaction BMP4 103.309387783476 85.9437747853154 120.675000781637 1.40411566844812 0.489661787083284 0.105142907918452 1 1.01947 1.42743 1.74469 1.65773 GeneID:652,Genbank:NM_001347912.1,HGNC:HGNC:1071,MIM:112262 bone morphogenetic protein 4 hsa04060,hsa04350,hsa04390,hsa04550,hsa04919,hsa05200,hsa05217,hsa05418 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Thyroid hormone signaling pathway|Pathways in cancer|Basal cell carcinoma|Fluid shear stress and atherosclerosis BMP5 5.02510706569928 6.65908587355536 3.3911282578432 0.509248314593763 -0.973558794426182 0.505226193548815 1 0.0115771 0.0113751 0.00374911 0.0069627 GeneID:653,Genbank:NM_001329756.1,HGNC:HGNC:1072,MIM:112265 bone morphogenetic protein 5 hsa04060,hsa04350,hsa04390 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway BMP6 182.439835334235 196.226406533374 168.653264135097 0.859483018186003 -0.21845895992035 0.370730998494115 1 1.85571 1.65477 1.94971 1.51273 GeneID:654,Genbank:NM_001718.5,HGNC:HGNC:1073,MIM:112266 bone morphogenetic protein 6 hsa04060,hsa04350,hsa04390,hsa04913 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Ovarian steroidogenesis BMP7 2.93888269973389 1.51824048055703 4.35952491891075 2.87143240793532 1.52177060181302 0.472583741512024 1 0.0125976 0.0224669 0.0236223 0.0770448 GeneID:655,Genbank:NM_001719.2,HGNC:HGNC:1074,MIM:112267 bone morphogenetic protein 7 hsa04060,hsa04350,hsa04360,hsa04390 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Axon guidance|Hippo signaling pathway BMP8A 2.46012245459701 2.49838328447175 2.42186162472226 0.969371529090393 -0.0448783844103732 1 1 0.00732294 0.0194304 0 0.0255585 GeneID:353500,Genbank:XM_006710616.3,HGNC:HGNC:21650 bone morphogenetic protein 8a hsa04060,hsa04350,hsa04390,hsa04714 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Thermogenesis BMP8B 37.4770734847034 36.187831504836 38.7663154645707 1.07125279002667 0.0992989617729237 0.874975672538029 1 0.17431 0.247477 0.204732 0.260892 GeneID:656,Genbank:NM_001720.4,HGNC:HGNC:1075,MIM:602284 bone morphogenetic protein 8b hsa04060,hsa04350,hsa04390,hsa04714 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Thermogenesis BMPER 24.1583841974805 19.7273175921334 28.5894508028275 1.4492315374001 0.535288106401809 0.348794508339724 1 0.201966 0.107993 0.212016 0.265422 GeneID:168667,Genbank:NM_133468.4,HGNC:HGNC:24154,MIM:608699 BMP binding endothelial regulator GO:0001657,GO:0002043,GO:0005615,GO:0010594,GO:0030514,GO:0042118,GO:0048839,GO:0060393,GO:0070374 ureteric bud development|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|extracellular space|regulation of endothelial cell migration|negative regulation of BMP signaling pathway|endothelial cell activation|inner ear development|regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of ERK1 and ERK2 cascade BMPR1A 744.03492334934 733.910808366314 754.159038332365 1.02758949689149 0.0392640494774824 0.806474004515835 1 5.07557 4.7942 5.84072 4.38758 GeneID:657,Genbank:XM_011540103.2,HGNC:HGNC:1076,MIM:601299 bone morphogenetic protein receptor type 1A GO:0000981,GO:0001701,GO:0001707,GO:0001756,GO:0001880,GO:0002053,GO:0002062,GO:0003148,GO:0003151,GO:0003161,GO:0003183,GO:0003186,GO:0003203,GO:0003215,GO:0003222,GO:0003223,GO:0003272,GO:0004674,GO:0004675,GO:0004702,GO:0005524,GO:0005886,GO:0006468,GO:0006955,GO:0007179,GO:0007398,GO:0009897,GO:0009950,GO:0010862,GO:0014032,GO:0014912,GO:0016021,GO:0019827,GO:0021983,GO:0021998,GO:0030324,GO:0030425,GO:0030501,GO:0030509,GO:0035137,GO:0035912,GO:0042475,GO:0042733,GO:0042803,GO:0043025,GO:0045669,GO:0045944,GO:0046332,GO:0046872,GO:0048352,GO:0048368,GO:0048378,GO:0048382,GO:0048568,GO:0048589,GO:0050679,GO:0050768,GO:0060021,GO:0060043,GO:0060045,GO:0060391,GO:0060914,GO:0061312,GO:0061626,GO:0071773,GO:0098821,GO:1902895,GO:1904414,GO:1904707,GO:1905285,GO:1990712,GO:2000772 RNA polymerase II transcription factor activity, sequence-specific DNA binding|in utero embryonic development|mesoderm formation|somitogenesis|Mullerian duct regression|positive regulation of mesenchymal cell proliferation|chondrocyte differentiation|outflow tract septum morphogenesis|outflow tract morphogenesis|cardiac conduction system development|mitral valve morphogenesis|tricuspid valve morphogenesis|endocardial cushion morphogenesis|cardiac right ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|ventricular compact myocardium morphogenesis|endocardial cushion formation|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|signal transducer, downstream of receptor, with serine/threonine kinase activity|ATP binding|plasma membrane|protein phosphorylation|immune response|transforming growth factor beta receptor signaling pathway|ectoderm development|external side of plasma membrane|dorsal/ventral axis specification|positive regulation of pathway-restricted SMAD protein phosphorylation|neural crest cell development|negative regulation of smooth muscle cell migration|integral component of membrane|stem cell population maintenance|pituitary gland development|neural plate mediolateral regionalization|lung development|dendrite|positive regulation of bone mineralization|BMP signaling pathway|hindlimb morphogenesis|dorsal aorta morphogenesis|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|protein homodimerization activity|neuronal cell body|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|SMAD binding|metal ion binding|paraxial mesoderm structural organization|lateral mesoderm development|regulation of lateral mesodermal cell fate specification|mesendoderm development|embryonic organ development|developmental growth|positive regulation of epithelial cell proliferation|negative regulation of neurogenesis|palate development|regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle cell proliferation|positive regulation of SMAD protein import into nucleus|heart formation|BMP signaling pathway involved in heart development|pharyngeal arch artery morphogenesis|cellular response to BMP stimulus|BMP receptor activity|positive regulation of pri-miRNA transcription from RNA polymerase II promoter|positive regulation of cardiac ventricle development|positive regulation of vascular smooth muscle cell proliferation|fibrous ring of heart morphogenesis|HFE-transferrin receptor complex|regulation of cellular senescence hsa04060,hsa04350,hsa04390,hsa04550,hsa05418 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis BMPR1B 178.762193017186 171.896341224884 185.628044809488 1.07988362920791 0.11087585256438 0.634443958801081 1 1.06876 0.939009 1.18357 0.962987 GeneID:658,Genbank:NM_001203.2,HGNC:HGNC:1077,MIM:603248 bone morphogenetic protein receptor type 1B GO:0001501,GO:0001502,GO:0001550,GO:0001654,GO:0002063,GO:0004674,GO:0004675,GO:0004702,GO:0005025,GO:0005524,GO:0005886,GO:0005887,GO:0006468,GO:0006954,GO:0009953,GO:0030166,GO:0030425,GO:0030501,GO:0030509,GO:0031290,GO:0032332,GO:0035108,GO:0042698,GO:0043025,GO:0043235,GO:0045597,GO:0045669,GO:0045944,GO:0046332,GO:0046872,GO:0060041,GO:0060350,GO:0061036,GO:0071773,GO:1902043,GO:1902731,GO:1990712 skeletal system development|cartilage condensation|ovarian cumulus expansion|eye development|chondrocyte development|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase activity|signal transducer, downstream of receptor, with serine/threonine kinase activity|transforming growth factor beta receptor activity, type I|ATP binding|plasma membrane|integral component of plasma membrane|protein phosphorylation|inflammatory response|dorsal/ventral pattern formation|proteoglycan biosynthetic process|dendrite|positive regulation of bone mineralization|BMP signaling pathway|retinal ganglion cell axon guidance|positive regulation of chondrocyte differentiation|limb morphogenesis|ovulation cycle|neuronal cell body|receptor complex|positive regulation of cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|SMAD binding|metal ion binding|retina development in camera-type eye|endochondral bone morphogenesis|positive regulation of cartilage development|cellular response to BMP stimulus|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of chondrocyte proliferation|HFE-transferrin receptor complex hsa04060,hsa04350,hsa04360,hsa04390,hsa04550,hsa05418 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Fluid shear stress and atherosclerosis BMPR2 489.352108868174 455.689607227753 523.014610508596 1.14774311771213 0.198799781148642 0.568030410200647 1 1.71135 1.38675 2.23314 1.40113 GeneID:659,Genbank:XM_011511687.1,HGNC:HGNC:1078,MIM:600799 bone morphogenetic protein receptor type 2 GO:0001707,GO:0001893,GO:0001935,GO:0001938,GO:0001946,GO:0001974,GO:0002063,GO:0003085,GO:0003148,GO:0003151,GO:0003183,GO:0003186,GO:0003197,GO:0003252,GO:0004702,GO:0005524,GO:0005615,GO:0005654,GO:0005737,GO:0005886,GO:0005887,GO:0005901,GO:0005913,GO:0006366,GO:0007178,GO:0007420,GO:0009267,GO:0009925,GO:0009952,GO:0009986,GO:0010595,GO:0010634,GO:0010862,GO:0014069,GO:0014916,GO:0016324,GO:0016362,GO:0019838,GO:0030166,GO:0030308,GO:0030425,GO:0030501,GO:0030509,GO:0030513,GO:0036122,GO:0042127,GO:0043025,GO:0044214,GO:0045669,GO:0045778,GO:0045906,GO:0045944,GO:0046872,GO:0048010,GO:0048286,GO:0048842,GO:0060173,GO:0060350,GO:0060412,GO:0060413,GO:0060836,GO:0060840,GO:0060841,GO:0061036,GO:0061298,GO:0061626,GO:0071773,GO:0072577,GO:0098821,GO:1902731,GO:1905314,GO:2000279 mesoderm formation|maternal placenta development|endothelial cell proliferation|positive regulation of endothelial cell proliferation|lymphangiogenesis|blood vessel remodeling|chondrocyte development|negative regulation of systemic arterial blood pressure|outflow tract septum morphogenesis|outflow tract morphogenesis|mitral valve morphogenesis|tricuspid valve morphogenesis|endocardial cushion development|negative regulation of cell proliferation involved in heart valve morphogenesis|signal transducer, downstream of receptor, with serine/threonine kinase activity|ATP binding|extracellular space|nucleoplasm|cytoplasm|plasma membrane|integral component of plasma membrane|caveola|cell-cell adherens junction|transcription from RNA polymerase II promoter|transmembrane receptor protein serine/threonine kinase signaling pathway|brain development|cellular response to starvation|basal plasma membrane|anterior/posterior pattern specification|cell surface|positive regulation of endothelial cell migration|positive regulation of epithelial cell migration|positive regulation of pathway-restricted SMAD protein phosphorylation|postsynaptic density|regulation of lung blood pressure|apical plasma membrane|activin receptor activity, type II|growth factor binding|proteoglycan biosynthetic process|negative regulation of cell growth|dendrite|positive regulation of bone mineralization|BMP signaling pathway|positive regulation of BMP signaling pathway|BMP binding|regulation of cell proliferation|neuronal cell body|spanning component of plasma membrane|positive regulation of osteoblast differentiation|positive regulation of ossification|negative regulation of vasoconstriction|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|vascular endothelial growth factor receptor signaling pathway|lung alveolus development|positive regulation of axon extension involved in axon guidance|limb development|endochondral bone morphogenesis|ventricular septum morphogenesis|atrial septum morphogenesis|lymphatic endothelial cell differentiation|artery development|venous blood vessel development|positive regulation of cartilage development|retina vasculature development in camera-type eye|pharyngeal arch artery morphogenesis|cellular response to BMP stimulus|endothelial cell apoptotic process|BMP receptor activity|negative regulation of chondrocyte proliferation|semi-lunar valve development|negative regulation of DNA biosynthetic process hsa04060,hsa04350,hsa04360,hsa04390,hsa04550,hsa05206,hsa05418 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|MicroRNAs in cancer|Fluid shear stress and atherosclerosis BMS1 1017.46044623481 1085.42896338781 949.491929081811 0.874761924648003 -0.193037668645126 0.316397421486882 1 4.49258 4.1178 4.32578 3.36185 GeneID:9790,Genbank:NM_014753.3,HGNC:HGNC:23505,MIM:611448 BMS1, ribosome biogenesis factor GO:0000462,GO:0000479,GO:0003723,GO:0003924,GO:0005524,GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0030686,GO:0034511 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|GTPase activity|ATP binding|GTP binding|nucleus|nucleoplasm|nucleolus|rRNA processing|90S preribosome|U3 snoRNA binding hsa03008 Ribosome biogenesis in eukaryotes BMT2 216.972817672953 233.778591039604 200.167044306302 0.856224872500804 -0.223938349854317 0.32748501223743 1 3.04881 2.85771 2.9392 2.30113 GeneID:154743,Genbank:NM_152556.2,HGNC:HGNC:26475,MIM:617855 base methyltransferase of 25S rRNA 2 homolog GO:0005730,GO:0016433,GO:0034198,GO:1904047,GO:1904262 nucleolus|rRNA (adenine) methyltransferase activity|cellular response to amino acid starvation|S-adenosyl-L-methionine binding|negative regulation of TORC1 signaling BMX 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:660,Genbank:NM_203281.2,HGNC:HGNC:1079,MIM:300101 BMX non-receptor tyrosine kinase GO:0001865,GO:0004713,GO:0004715,GO:0004871,GO:0005524,GO:0005654,GO:0005829,GO:0005886,GO:0006468,GO:0006661,GO:0007155,GO:0007165,GO:0007169,GO:0007498,GO:0031234,GO:0032587,GO:0035556,GO:0038083,GO:0042127,GO:0045087,GO:0046777,GO:0046872,GO:0097194 NK T cell differentiation|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signal transducer activity|ATP binding|nucleoplasm|cytosol|plasma membrane|protein phosphorylation|phosphatidylinositol biosynthetic process|cell adhesion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|mesoderm development|extrinsic component of cytoplasmic side of plasma membrane|ruffle membrane|intracellular signal transduction|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|innate immune response|protein autophosphorylation|metal ion binding|execution phase of apoptosis BNC1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00641618 GeneID:646,Genbank:XM_011521893.1,HGNC:HGNC:1081,MIM:601930 basonuclin 1 GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0007283,GO:0008284,GO:0008544,GO:0030154,GO:0043231,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|spermatogenesis|positive regulation of cell proliferation|epidermis development|cell differentiation|intracellular membrane-bounded organelle|metal ion binding BNC2 652.079409225294 701.181885639649 602.97693281094 0.85994368245962 -0.217685913789667 0.440702037212673 1 1.1934 0.997901 1.13784 0.736661 GeneID:54796,Genbank:NM_001317939.1,HGNC:HGNC:30988,MIM:608669 basonuclin 2 GO:0003416,GO:0003677,GO:0005654,GO:0006351,GO:0006355,GO:0043586,GO:0046872,GO:0060021,GO:0060485 endochondral bone growth|DNA binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|tongue development|metal ion binding|palate development|mesenchyme development BNIP1 373.701736427316 405.281930412755 342.121542441877 0.844156910951957 -0.244416904471714 0.187338773009249 1 5.67925 6.93818 4.85455 5.8393 GeneID:662,Genbank:NM_013979.2,HGNC:HGNC:1082,MIM:603291 BCL2 interacting protein 1 hsa04130 SNARE interactions in vesicular transport BNIP2 954.140007659254 1052.85392814031 855.426087178196 0.812483160593 -0.299590182635187 0.0739590642856099 0.937126877846779 6.30816 5.54732 5.37517 4.37142 GeneID:663,Genbank:NM_004330.3,HGNC:HGNC:1083,MIM:603292 BCL2 interacting protein 2 BNIP3 2512.44643819019 2415.39171369553 2609.50116268484 1.08036354844172 0.111516869126937 0.481259082393523 1 62.901 63.0015 63.8776 72.9988 GeneID:664,Genbank:NM_004052.3,HGNC:HGNC:1084,MIM:603293 BCL2 interacting protein 3 hsa04068,hsa04137,hsa04140,hsa05134 FoxO signaling pathway|Mitophagy - animal|Autophagy - animal|Legionellosis BNIP3L 1127.09614663352 1133.6852664971 1120.50702676995 0.988375751086657 -0.0168684790164675 0.945655040922593 1 13.0561 11.5811 13.0453 11.2543 GeneID:665,Genbank:NM_004331.2,HGNC:HGNC:1085,MIM:605368 BCL2 interacting protein 3 like hsa04137 Mitophagy - animal BNIPL 5.02010396632909 5.67894306964064 4.36126486301754 0.767971224492927 -0.380875840007471 0.852393033950403 1 0.0496038 0.0606152 0.0625923 0.0582972 GeneID:149428,Genbank:XM_024453491.1,HGNC:HGNC:16976,MIM:611275 BCL2 interacting protein like GO:0005634,GO:0005829,GO:0006915,GO:0008285,GO:0040009,GO:0042802 nucleus|cytosol|apoptotic process|negative regulation of cell proliferation|regulation of growth rate|identical protein binding BOC 141.224244192216 123.486150636438 158.962337747995 1.2872887925384 0.364335746507089 0.162983864244917 1 0.562846 0.598899 0.758886 0.782924 GeneID:91653,Genbank:XM_017007446.1,HGNC:HGNC:17173,MIM:608708 BOC cell adhesion associated, oncogene regulated GO:0005654,GO:0005886,GO:0005887,GO:0007155,GO:0007224,GO:0007411,GO:0044295,GO:0045663,GO:0051149 nucleoplasm|plasma membrane|integral component of plasma membrane|cell adhesion|smoothened signaling pathway|axon guidance|axonal growth cone|positive regulation of myoblast differentiation|positive regulation of muscle cell differentiation hsa04340,hsa04360 Hedgehog signaling pathway|Axon guidance BOD1 1291.46778597881 1246.3438540175 1336.59171794012 1.07241008461005 0.100856691151226 0.495585351340627 1 21.3436 21.1003 23.2763 22.8485 GeneID:91272,Genbank:NM_001159651.1,HGNC:HGNC:25114,MIM:616745 biorientation of chromosomes in cell division 1 GO:0000922,GO:0000940,GO:0004864,GO:0005737,GO:0005813,GO:0005876,GO:0007080,GO:0032515,GO:0051301,GO:0051721,GO:0071459,GO:0071962,GO:1990758 spindle pole|condensed chromosome outer kinetochore|protein phosphatase inhibitor activity|cytoplasm|centrosome|spindle microtubule|mitotic metaphase plate congression|negative regulation of phosphoprotein phosphatase activity|cell division|protein phosphatase 2A binding|protein localization to chromosome, centromeric region|mitotic sister chromatid cohesion, centromeric|mitotic sister chromatid biorientation BOD1L1 213.795992332609 211.879265430685 215.712719234534 1.01809263306655 0.0258688336982389 0.941227199225409 1 0.566131 0.406762 0.650921 0.347972 GeneID:259282,Genbank:XM_017008010.1,HGNC:HGNC:31792,MIM:616746 biorientation of chromosomes in cell division 1 like 1 GO:0005654,GO:0005694,GO:0006281,GO:0006974,GO:0031297 nucleoplasm|chromosome|DNA repair|cellular response to DNA damage stimulus|replication fork processing BOK 331.315940821808 300.600789494329 362.031092149286 1.20435842087539 0.268264806605701 0.176027191461061 1 3.87098 4.30246 5.09069 4.8307 GeneID:666,Genbank:NM_032515.4,HGNC:HGNC:1087,MIM:605404 BOK, BCL2 family apoptosis regulator hsa04215 Apoptosis - multiple species BOLA1 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.0964169 0 0 0 GeneID:51027,Genbank:NM_001321026.1,HGNC:HGNC:24263,MIM:613181 bolA family member 1 GO:0005739 mitochondrion BOLA2-SMG1P6 32.7407902124118 35.9280828211954 29.5534976036281 0.822573744073905 -0.281783072038739 0.728439558053373 1 1.97748 0.992369 1.34015 1.33399 GeneID:107282092,Genbank:NM_001320625.1,HGNC:HGNC:53563 BOLA2-SMG1P6 readthrough GO:0000184,GO:0003723,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006406,GO:0006950,GO:0018105,GO:0032204,GO:0042162,GO:0046777,GO:0046854,GO:0046872 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|mRNA export from nucleus|response to stress|peptidyl-serine phosphorylation|regulation of telomere maintenance|telomeric DNA binding|protein autophosphorylation|phosphatidylinositol phosphorylation|metal ion binding BOLA2B 29.7393630424016 38.6381885146228 20.8405375701804 0.539376672959012 -0.890634965850135 0.083474983744911 0.963076417285947 0.480572 0.946915 0.586812 1.1591 GeneID:654483,Genbank:NM_001320607.1,HGNC:HGNC:32479 bolA family member 2B GO:0005634,GO:0005737,GO:0005829,GO:0035722,GO:0044571,GO:0070062,GO:0097428 nucleus|cytoplasm|cytosol|interleukin-12-mediated signaling pathway|[2Fe-2S] cluster assembly|extracellular exosome|protein maturation by iron-sulfur cluster transfer BOLA3 494.023916886595 492.782163298205 495.265670474986 1.00503976678084 0.00725258618279232 0.989556658750086 1 30.5551 32.8681 32.9317 32.342 GeneID:388962,Genbank:NM_001035505.1,HGNC:HGNC:24415,MIM:613183 bolA family member 3 GO:0005739 mitochondrion BOP1 1764.96359029109 1919.16350127683 1610.76367930534 0.839305081736752 -0.252732778971919 0.158854650129656 1 29.607 32.4624 24.4339 28.1242 GeneID:23246,Genbank:NM_015201.4,HGNC:HGNC:15519,MIM:610596 block of proliferation 1 BORA 207.900415006901 212.225258008588 203.575572005214 0.959242900281811 -0.0600319129494449 0.879798163307163 1 2.7832 2.18047 2.70053 1.80771 GeneID:79866,Genbank:XM_006719868.4,HGNC:HGNC:24724,MIM:610510 bora, aurora kinase A activator GO:0000086,GO:0005829,GO:0007088,GO:0019901,GO:0032880,GO:0051301,GO:0060236 G2/M transition of mitotic cell cycle|cytosol|regulation of mitotic nuclear division|protein kinase binding|regulation of protein localization|cell division|regulation of mitotic spindle organization BORCS5 248.600500495787 240.351433018897 256.849567972676 1.06864171661702 0.0957782419268711 0.652318039264446 1 1.2979 1.2554 1.4114 1.4055 GeneID:118426,Genbank:XM_011520551.2,HGNC:HGNC:17950,MIM:616598 BLOC-1 related complex subunit 5 GO:0031224,GO:0032418,GO:0072384,GO:0098574,GO:0099078 intrinsic component of membrane|lysosome localization|organelle transport along microtubule|cytoplasmic side of lysosomal membrane|BORC complex BORCS6 275.711866480347 248.04849662616 303.375236334535 1.22304807511798 0.29048111389894 0.159473055469413 1 6.52318 6.30399 8.06025 7.90497 GeneID:54785,Genbank:NM_017622.2,HGNC:HGNC:25939,MIM:616599 BLOC-1 related complex subunit 6 GO:0005765,GO:0032418,GO:0099078 lysosomal membrane|lysosome localization|BORC complex BORCS7 334.169484449844 355.285855758851 313.053113140836 0.881130245030976 -0.182572806760948 0.340477612468004 1 6.37671 7.57562 5.82216 6.37674 GeneID:119032,Genbank:NM_001136200.1,HGNC:HGNC:23516,MIM:616600 BLOC-1 related complex subunit 7 GO:0005765,GO:0099078 lysosomal membrane|BORC complex BORCS8 287.105051996325 292.173523111684 282.036580880966 0.965305062133084 -0.050943150355625 0.79562330576805 1 8.09703 9.58239 8.76836 9.72097 GeneID:729991,Genbank:NM_001145784.1,HGNC:HGNC:37247,MIM:616601 BLOC-1 related complex subunit 8 GO:0005765,GO:0007507,GO:0099078 lysosomal membrane|heart development|BORC complex BPGM 931.243258405661 928.138711672281 934.34780513904 1.00668983352238 0.00961924981257264 0.935501685823072 1 15.1197 13.8256 14.6345 14.3497 GeneID:669,Genbank:NM_001293085.1,HGNC:HGNC:1093,MIM:613896 bisphosphoglycerate mutase GO:0004082,GO:0005829,GO:0005975,GO:0006094,GO:0006096,GO:0007585,GO:0016787,GO:0043456,GO:0046538,GO:0048821,GO:0061621,GO:0070062 bisphosphoglycerate mutase activity|cytosol|carbohydrate metabolic process|gluconeogenesis|glycolytic process|respiratory gaseous exchange|hydrolase activity|regulation of pentose-phosphate shunt|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity|erythrocyte development|canonical glycolysis|extracellular exosome hsa00010,hsa00260 Glycolysis / Gluconeogenesis|Glycine, serine and threonine metabolism BPHL 374.968170901131 359.359297452818 390.577044349444 1.08687056969974 0.120180146832393 0.520566585412674 1 7.36384 6.20325 7.17476 8.28192 GeneID:670,Genbank:NM_001302777.1,HGNC:HGNC:1094,MIM:603156 biphenyl hydrolase like GO:0005739,GO:0005741,GO:0006520,GO:0006805,GO:0009636,GO:0016787,GO:0047658,GO:0070062 mitochondrion|mitochondrial outer membrane|cellular amino acid metabolic process|xenobiotic metabolic process|response to toxic substance|hydrolase activity|alpha-amino-acid esterase activity|extracellular exosome BPIFB3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0299285 GeneID:359710,Genbank:NM_182658.2,HGNC:HGNC:16178,MIM:615717 BPI fold containing family B member 3 GO:0005576,GO:0005737,GO:0008289,GO:0045087 extracellular region|cytoplasm|lipid binding|innate immune response BPNT1 920.66326628085 943.370159753391 897.956372808309 0.951860055699711 -0.0711786135694155 0.644737624570552 1 7.28719 8.21003 6.99969 7.40752 GeneID:10380,Genbank:NM_001286149.1,HGNC:HGNC:1096,MIM:604053 3'(2'), 5'-bisphosphate nucleotidase 1 GO:0005829,GO:0006139,GO:0007399,GO:0008441,GO:0046854,GO:0046872,GO:0050427,GO:0070062 cytosol|nucleobase-containing compound metabolic process|nervous system development|3'(2'),5'-bisphosphate nucleotidase activity|phosphatidylinositol phosphorylation|metal ion binding|3'-phosphoadenosine 5'-phosphosulfate metabolic process|extracellular exosome hsa00920 Sulfur metabolism BPTF 510.559365872279 479.193417211491 541.925314533068 1.1309114338144 0.177485950548005 0.620371788121433 1 1.11019 0.86394 1.39169 0.834321 GeneID:2186,Genbank:XM_005257152.3,HGNC:HGNC:3581,MIM:601819 bromodomain PHD finger transcription factor GO:0000122,GO:0000790,GO:0001892,GO:0005634,GO:0005654,GO:0005737,GO:0006338,GO:0006351,GO:0006355,GO:0007420,GO:0007492,GO:0008134,GO:0009611,GO:0009952,GO:0016569,GO:0016589,GO:0030425,GO:0043565,GO:0044297,GO:0045893,GO:0046872,GO:0048471,GO:0070062,GO:1990090 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|embryonic placenta development|nucleus|nucleoplasm|cytoplasm|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|brain development|endoderm development|transcription factor binding|response to wounding|anterior/posterior pattern specification|covalent chromatin modification|NURF complex|dendrite|sequence-specific DNA binding|cell body|positive regulation of transcription, DNA-templated|metal ion binding|perinuclear region of cytoplasm|extracellular exosome|cellular response to nerve growth factor stimulus BRAF 336.392599663345 336.873847892572 335.911351434118 0.997142857884411 -0.00412788454977485 0.995661628416447 1 1.19265 0.966333 1.2765 0.799761 GeneID:673,Genbank:NM_001354609.1,HGNC:HGNC:1097,MIM:164757 B-Raf proto-oncogene, serine/threonine kinase hsa01521,hsa01522,hsa04010,hsa04012,hsa04015,hsa04024,hsa04062,hsa04068,hsa04150,hsa04270,hsa04510,hsa04650,hsa04720,hsa04722,hsa04726,hsa04730,hsa04810,hsa04910,hsa04914,hsa04928,hsa04934,hsa05034,hsa05160,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|mTOR signaling pathway|Vascular smooth muscle contraction|Focal adhesion|Natural killer cell mediated cytotoxicity|Long-term potentiation|Neurotrophin signaling pathway|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Alcoholism|Hepatitis C|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer BRAP 423.419361242866 439.239918971013 407.598803514718 0.927963934766177 -0.107859358656352 0.557962515454874 1 3.20295 3.40001 3.38099 2.8332 GeneID:8315,Genbank:XM_017019994.1,HGNC:HGNC:1099,MIM:604986 BRCA1 associated protein GO:0000151,GO:0000165,GO:0003676,GO:0004842,GO:0005737,GO:0005829,GO:0007265,GO:0008139,GO:0008270,GO:0009968,GO:0016567,GO:0031965,GO:0042802,GO:0061630 ubiquitin ligase complex|MAPK cascade|nucleic acid binding|ubiquitin-protein transferase activity|cytoplasm|cytosol|Ras protein signal transduction|nuclear localization sequence binding|zinc ion binding|negative regulation of signal transduction|protein ubiquitination|nuclear membrane|identical protein binding|ubiquitin protein ligase activity hsa04014 Ras signaling pathway BRAT1 1656.53871491087 1673.2183520817 1639.85907774004 0.980062808718205 -0.0290538855343543 0.833665926433033 1 17.0288 17.2276 15.1579 17.8058 GeneID:221927,Genbank:NM_001350627.1,HGNC:HGNC:21701,MIM:614506 BRCA1 associated ATM activator 1 GO:0001934,GO:0005634,GO:0005654,GO:0005737,GO:0006006,GO:0006915,GO:0006974,GO:0008283,GO:0010212,GO:0016020,GO:0016477,GO:0030307,GO:0051646 positive regulation of protein phosphorylation|nucleus|nucleoplasm|cytoplasm|glucose metabolic process|apoptotic process|cellular response to DNA damage stimulus|cell proliferation|response to ionizing radiation|membrane|cell migration|positive regulation of cell growth|mitochondrion localization BRCA1 477.309753606648 489.773074300705 464.846432912592 0.949105733458902 -0.0753592777782705 0.837079167436698 1 2.00913 1.69474 2.1567 1.33322 GeneID:672,Genbank:NM_007294.3,HGNC:HGNC:1100,MIM:113705 BRCA1, DNA repair associated hsa01524,hsa03440,hsa03460,hsa04120,hsa04151,hsa05206,hsa05224 Platinum drug resistance|Homologous recombination|Fanconi anemia pathway|Ubiquitin mediated proteolysis|PI3K-Akt signaling pathway|MicroRNAs in cancer|Breast cancer BRCA2 27.425349048343 26.7323960435913 28.1183020530947 1.05184368835638 0.0729203255537271 0.931299071991112 1 0.0755941 0.0653974 0.110181 0.0511642 GeneID:675,Genbank:NM_000059.3,HGNC:HGNC:1101,MIM:600185 BRCA2, DNA repair associated hsa03440,hsa03460,hsa05200,hsa05212,hsa05224 Homologous recombination|Fanconi anemia pathway|Pathways in cancer|Pancreatic cancer|Breast cancer BRCC3 521.198673278535 540.787509378101 501.609837178969 0.927554406269136 -0.108496188514954 0.561403140479083 1 2.3533 1.93199 2.15893 1.82676 GeneID:79184,Genbank:XM_017029838.1,HGNC:HGNC:24185,MIM:300617 BRCA1/BRCA2-containing complex subunit 3 GO:0000151,GO:0000152,GO:0000922,GO:0004843,GO:0005634,GO:0005654,GO:0005737,GO:0006302,GO:0007049,GO:0008237,GO:0010165,GO:0010212,GO:0030234,GO:0031593,GO:0036459,GO:0045739,GO:0046872,GO:0051301,GO:0070531,GO:0070536,GO:0070537,GO:0070552,GO:0072425 ubiquitin ligase complex|nuclear ubiquitin ligase complex|spindle pole|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|cytoplasm|double-strand break repair|cell cycle|metallopeptidase activity|response to X-ray|response to ionizing radiation|enzyme regulator activity|polyubiquitin modification-dependent protein binding|thiol-dependent ubiquitinyl hydrolase activity|positive regulation of DNA repair|metal ion binding|cell division|BRCA1-A complex|protein K63-linked deubiquitination|histone H2A K63-linked deubiquitination|BRISC complex|signal transduction involved in G2 DNA damage checkpoint hsa03440,hsa04621 Homologous recombination|NOD-like receptor signaling pathway BRD1 783.500826492537 816.309430479197 750.692222505877 0.919617236401641 -0.120894588119951 0.446348741623536 1 2.88213 2.887 2.77178 2.56282 GeneID:23774,Genbank:NM_001304808.2,HGNC:HGNC:1102,MIM:604589 bromodomain containing 1 GO:0005634,GO:0016607,GO:0030425,GO:0035902,GO:0042393,GO:0043204,GO:0043966,GO:0046872,GO:0051602,GO:0070776 nucleus|nuclear speck|dendrite|response to immobilization stress|histone binding|perikaryon|histone H3 acetylation|metal ion binding|response to electrical stimulus|MOZ/MORF histone acetyltransferase complex BRD2 5859.74107917443 5827.79188402102 5891.69027432784 1.01096442556262 0.0157322316945702 0.904260618848162 1 34.7435 34.0201 36.0245 34.7 GeneID:6046,Genbank:NM_005104.3,HGNC:HGNC:1103,MIM:601540 bromodomain containing 2 GO:0003682,GO:0005654,GO:0005737,GO:0006334,GO:0006351,GO:0006357,GO:0007283,GO:0016569,GO:0016607,GO:0070577 chromatin binding|nucleoplasm|cytoplasm|nucleosome assembly|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|spermatogenesis|covalent chromatin modification|nuclear speck|lysine-acetylated histone binding BRD3 793.582107833343 739.042862105059 848.121353561626 1.14759426962852 0.198612669316149 0.211686085404345 1 4.5783 4.50967 5.51697 5.1273 GeneID:8019,Genbank:NM_007371.3,HGNC:HGNC:1104,MIM:601541 bromodomain containing 3 GO:0003682,GO:0005634,GO:0006351,GO:0006357,GO:0016569,GO:0070577 chromatin binding|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|covalent chromatin modification|lysine-acetylated histone binding BRD3OS 537.099000347565 546.929131886084 527.268868809045 0.964053362801794 -0.0528150893877434 0.751984251130948 1 9.8028 10.3327 9.90552 9.66102 GeneID:266655,Genbank:NM_001355256.1,HGNC:HGNC:24742 BRD3 opposite strand BRD4 2120.56233257082 2114.47537458948 2126.64929055215 1.00575741676114 0.00828237687486164 0.96093468848298 1 8.182 7.97926 8.90462 7.56653 GeneID:23476,Genbank:XM_011527854.2,HGNC:HGNC:13575,MIM:608749 bromodomain containing 4 BRD7 2015.95684731599 2060.86345267568 1971.05024195629 0.956419620813412 -0.0642843678492697 0.670295732893958 1 10.9673 10.1156 10.3129 9.33597 GeneID:29117,Genbank:XM_011523046.3,HGNC:HGNC:14310 bromodomain containing 7 GO:0002039,GO:0003713,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006357,GO:0007049,GO:0008134,GO:0008285,GO:0016055,GO:0035066,GO:0042393,GO:0044212,GO:0045892,GO:0045893,GO:0070577,GO:1901796,GO:2000134 p53 binding|transcription coactivator activity|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|cell cycle|transcription factor binding|negative regulation of cell proliferation|Wnt signaling pathway|positive regulation of histone acetylation|histone binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|lysine-acetylated histone binding|regulation of signal transduction by p53 class mediator|negative regulation of G1/S transition of mitotic cell cycle hsa05225 Hepatocellular carcinoma BRD8 1595.28430025978 1666.40334472727 1524.16525579228 0.914643660920958 -0.128718306410856 0.377281093228804 1 8.7011 8.42546 8.04883 7.76674 GeneID:10902,Genbank:XM_005271859.4,HGNC:HGNC:19874,MIM:602848 bromodomain containing 8 GO:0000812,GO:0005654,GO:0005739,GO:0006351,GO:0035267,GO:0040008,GO:0043967,GO:0043968,GO:0045944 Swr1 complex|nucleoplasm|mitochondrion|transcription, DNA-templated|NuA4 histone acetyltransferase complex|regulation of growth|histone H4 acetylation|histone H2A acetylation|positive regulation of transcription from RNA polymerase II promoter BRD9 902.755571372297 888.098969537542 917.412173207053 1.03300668582554 0.0468495916435681 0.772935510288243 1 2.72168 2.79892 2.92865 2.8316 GeneID:65980,Genbank:NM_023924.4,HGNC:HGNC:25818 bromodomain containing 9 GO:0003676,GO:0006351,GO:0006355,GO:0016569,GO:0070577 nucleic acid binding|transcription, DNA-templated|regulation of transcription, DNA-templated|covalent chromatin modification|lysine-acetylated histone binding BRF1 741.973473467419 730.87636140691 753.070585527929 1.03036659179714 0.0431577219444736 0.832602732045226 1 3.48913 3.79601 3.97681 4.38191 GeneID:2972,Genbank:NM_001242787.1,HGNC:HGNC:11551,MIM:604902 BRF1, RNA polymerase III transcription initiation factor subunit GO:0000126,GO:0001026,GO:0005654,GO:0006383,GO:0006384,GO:0009303,GO:0009304,GO:0017025,GO:0045945,GO:0046872,GO:0070897 transcription factor TFIIIB complex|TFIIIB-type transcription factor activity|nucleoplasm|transcription from RNA polymerase III promoter|transcription initiation from RNA polymerase III promoter|rRNA transcription|tRNA transcription|TBP-class protein binding|positive regulation of transcription from RNA polymerase III promoter|metal ion binding|DNA-templated transcriptional preinitiation complex assembly BRF2 525.82544526099 500.661523349099 550.98936717288 1.10052269143257 0.138188892144269 0.434884208198804 1 10.6934 11.4743 11.417 13.0233 GeneID:55290,Genbank:NM_018310.3,HGNC:HGNC:17298,MIM:607013 BRF2, RNA polymerase III transcription initiation factor subunit GO:0001007,GO:0001032,GO:0005654,GO:0006359,GO:0034599,GO:0046872,GO:0070897 transcription factor activity, RNA polymerase III transcription factor binding|RNA polymerase III type 3 promoter DNA binding|nucleoplasm|regulation of transcription from RNA polymerase III promoter|cellular response to oxidative stress|metal ion binding|DNA-templated transcriptional preinitiation complex assembly BRI3 2304.09494703532 2002.39615336787 2605.79374070277 1.30133776791373 0.379995468472861 0.00665892482658113 0.323179818250071 13.7585 14.9493 18.6836 18.8296 GeneID:25798,Genbank:NM_001159491.1,HGNC:HGNC:1109,MIM:615628 brain protein I3 GO:0005886,GO:0016021,GO:0035577,GO:0042802,GO:0043312 plasma membrane|integral component of membrane|azurophil granule membrane|identical protein binding|neutrophil degranulation BRI3BP 231.786783809936 239.679065173308 223.894502446564 0.934142922681501 -0.0982847975548556 0.649683985968686 1 4.65392 5.11634 4.2286 4.75972 GeneID:140707,Genbank:NM_080626.5,HGNC:HGNC:14251,MIM:615627 BRI3 binding protein GO:0005739,GO:0005741,GO:0016021 mitochondrion|mitochondrial outer membrane|integral component of membrane BRICD5 24.6752110403956 25.6081744156218 23.7422476651694 0.927135502899649 -0.109147887562929 0.880817306977383 1 0.631701 0.580092 0.436425 0.724845 GeneID:283870,Genbank:NM_182563.3,HGNC:HGNC:28309 BRICHOS domain containing 5 GO:0005615,GO:0016021,GO:0042127 extracellular space|integral component of membrane|regulation of cell proliferation BRINP1 146.753501037775 118.537410342179 174.969591733371 1.47607064494062 0.561761770630373 0.0279193989788335 0.668561867500627 1.43926 1.34441 2.36594 1.76113 GeneID:1620,Genbank:NM_014618.2,HGNC:HGNC:2687,MIM:602865 BMP/retinoic acid inducible neural specific 1 GO:0001662,GO:0005737,GO:0005783,GO:0007050,GO:0007614,GO:0008219,GO:0030425,GO:0035176,GO:0035640,GO:0042711,GO:0043025,GO:0045666,GO:0045786,GO:0045930,GO:0050768,GO:0071300,GO:0071625 behavioral fear response|cytoplasm|endoplasmic reticulum|cell cycle arrest|short-term memory|cell death|dendrite|social behavior|exploration behavior|maternal behavior|neuronal cell body|positive regulation of neuron differentiation|negative regulation of cell cycle|negative regulation of mitotic cell cycle|negative regulation of neurogenesis|cellular response to retinoic acid|vocalization behavior BRINP2 0.980142803914724 1.96028560782945 0 0 -Inf 0.468110954943058 1 0 0.0210478 0 0 GeneID:57795,Genbank:XM_005245379.2,HGNC:HGNC:13746 BMP/retinoic acid inducible neural specific 2 GO:0005576,GO:0005783,GO:0007050,GO:0030425,GO:0043025,GO:0045666,GO:0045930,GO:0071300 extracellular region|endoplasmic reticulum|cell cycle arrest|dendrite|neuronal cell body|positive regulation of neuron differentiation|negative regulation of mitotic cell cycle|cellular response to retinoic acid BRINP3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00552855 0 0 GeneID:339479,Genbank:XM_017001127.1,HGNC:HGNC:22393 BMP/retinoic acid inducible neural specific 3 GO:0005576,GO:0005739,GO:0005783,GO:0007050,GO:0030425,GO:0043025,GO:0045666,GO:0045930,GO:0071300 extracellular region|mitochondrion|endoplasmic reticulum|cell cycle arrest|dendrite|neuronal cell body|positive regulation of neuron differentiation|negative regulation of mitotic cell cycle|cellular response to retinoic acid BRIP1 164.573851463308 172.578517725581 156.569185201035 0.907234499777063 -0.14045259161019 0.710123621332198 1 0.512941 0.411964 0.550374 0.304623 GeneID:83990,Genbank:NM_032043.2,HGNC:HGNC:20473,MIM:605882 BRCA1 interacting protein C-terminal helicase 1 hsa03440,hsa03460 Homologous recombination|Fanconi anemia pathway BRIX1 792.754932131095 871.185584841604 714.324279420586 0.819945017284075 -0.286400924121415 0.0758026803342944 0.94157495521624 24.4612 21.9736 18.8295 18.8496 GeneID:55299,Genbank:NM_018321.3,HGNC:HGNC:24170 BRX1, biogenesis of ribosomes GO:0000027,GO:0003723,GO:0005634,GO:0005730 ribosomal large subunit assembly|RNA binding|nucleus|nucleolus BRK1 4882.62741291258 4666.75089691028 5098.50392891488 1.09251683699047 0.127655513552405 0.345131583062046 1 188.831 202.947 207.646 223.591 GeneID:55845,Genbank:NM_018462.4,HGNC:HGNC:23057,MIM:611183 BRICK1, SCAR/WAVE actin nucleating complex subunit GO:0001701,GO:0005829,GO:0005856,GO:0007015,GO:0008284,GO:0010592,GO:0016601,GO:0030027,GO:0031209,GO:0032403,GO:0038096,GO:0048010,GO:0048870,GO:0070062,GO:0070207,GO:2000601 in utero embryonic development|cytosol|cytoskeleton|actin filament organization|positive regulation of cell proliferation|positive regulation of lamellipodium assembly|Rac protein signal transduction|lamellipodium|SCAR complex|protein complex binding|Fc-gamma receptor signaling pathway involved in phagocytosis|vascular endothelial growth factor receptor signaling pathway|cell motility|extracellular exosome|protein homotrimerization|positive regulation of Arp2/3 complex-mediated actin nucleation hsa04810 Regulation of actin cytoskeleton BRMS1 1141.61674165427 1153.18429537262 1130.04918793592 0.979938065815204 -0.0292375241950585 0.856194618914327 1 29.7682 28.4084 25.9649 30.6628 GeneID:25855,Genbank:XM_024448426.1,HGNC:HGNC:17262,MIM:606259 breast cancer metastasis suppressor 1 BRMS1L 155.131275285943 191.03753486569 119.225015706196 0.624092096822847 -0.680169152617899 0.00704037752601928 0.334595508773664 1.69784 1.5872 1.18618 0.919784 GeneID:84312,Genbank:XM_017021706.1,HGNC:HGNC:20512 breast cancer metastasis-suppressor 1 like GO:0000122,GO:0006351,GO:0016575,GO:0040008,GO:0042826,GO:0070822 negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|histone deacetylation|regulation of growth|histone deacetylase binding|Sin3-type complex BROX 489.481298499019 479.751132198349 499.211464799688 1.04056339067334 0.0573648561105958 0.726753299845816 1 4.06583 3.7471 4.6082 3.45765 GeneID:148362,Genbank:NM_144695.3,HGNC:HGNC:26512 BRO1 domain and CAAX motif containing GO:0016020,GO:0070062 membrane|extracellular exosome BRPF1 1082.92867271836 1004.20564018015 1161.65170525657 1.15678667672906 0.210122841281672 0.169064027144113 1 5.71407 5.88744 7.15699 6.6988 GeneID:7862,Genbank:NM_001319049.1,HGNC:HGNC:14255,MIM:602410 bromodomain and PHD finger containing 1 GO:0003677,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0043966,GO:0043972,GO:0045893,GO:0046872,GO:0070776,GO:1901796 DNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|histone H3 acetylation|histone H3-K23 acetylation|positive regulation of transcription, DNA-templated|metal ion binding|MOZ/MORF histone acetyltransferase complex|regulation of signal transduction by p53 class mediator BRPF3 1424.03682244462 1362.13395804753 1485.93968684172 1.09089100823215 0.125506968079675 0.399378902763837 1 7.00599 7.3516 8.42005 7.24694 GeneID:27154,Genbank:NM_015695.2,HGNC:HGNC:14256,MIM:616856 bromodomain and PHD finger containing 3 GO:0002576,GO:0005576,GO:0005829,GO:0043966,GO:0046872,GO:0070776 platelet degranulation|extracellular region|cytosol|histone H3 acetylation|metal ion binding|MOZ/MORF histone acetyltransferase complex BRSK1 464.762563244618 482.68276895584 446.842357533395 0.925747481104461 -0.111309375959586 0.527708112893896 1 4.83633 4.91593 4.97937 4.34764 GeneID:84446,Genbank:XM_005259327.3,HGNC:HGNC:18994,MIM:609235 BR serine/threonine kinase 1 GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006468,GO:0006974,GO:0007269,GO:0007409,GO:0008021,GO:0009411,GO:0019901,GO:0030010,GO:0030054,GO:0030182,GO:0031572,GO:0035556,GO:0043015,GO:0050321,GO:0051298 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|protein phosphorylation|cellular response to DNA damage stimulus|neurotransmitter secretion|axonogenesis|synaptic vesicle|response to UV|protein kinase binding|establishment of cell polarity|cell junction|neuron differentiation|G2 DNA damage checkpoint|intracellular signal transduction|gamma-tubulin binding|tau-protein kinase activity|centrosome duplication BRSK2 143.21561349534 158.011662836662 128.419564154018 0.812722060185938 -0.299166040187111 0.240622418111425 1 0.936525 0.944779 0.783064 0.85173 GeneID:9024,Genbank:NM_001256629.1,HGNC:HGNC:11405,MIM:609236 BR serine/threonine kinase 2 GO:0000086,GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005783,GO:0005813,GO:0006468,GO:0006887,GO:0007409,GO:0018105,GO:0019901,GO:0030010,GO:0030182,GO:0031532,GO:0036503,GO:0043462,GO:0048471,GO:0050321,GO:0051117,GO:0051301,GO:0060590,GO:0061178,GO:0070059,GO:1904152 G2/M transition of mitotic cell cycle|magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|endoplasmic reticulum|centrosome|protein phosphorylation|exocytosis|axonogenesis|peptidyl-serine phosphorylation|protein kinase binding|establishment of cell polarity|neuron differentiation|actin cytoskeleton reorganization|ERAD pathway|regulation of ATPase activity|perinuclear region of cytoplasm|tau-protein kinase activity|ATPase binding|cell division|ATPase regulator activity|regulation of insulin secretion involved in cellular response to glucose stimulus|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|regulation of retrograde protein transport, ER to cytosol BRWD1 172.188732309351 190.739568562473 153.63789605623 0.805485181780252 -0.312070046450599 0.20657578353047 1 0.336457 0.300839 0.292072 0.247164 GeneID:54014,Genbank:XM_017028373.1,HGNC:HGNC:12760,MIM:617824 bromodomain and WD repeat domain containing 1 GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006325,GO:0006351,GO:0006357,GO:0007010,GO:0008360,GO:0038111 nucleus|nucleoplasm|nucleolus|cytosol|chromatin organization|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|cytoskeleton organization|regulation of cell shape|interleukin-7-mediated signaling pathway BRWD3 173.087136864067 176.018826194391 170.155447533742 0.966688911706678 -0.0488764014054435 0.922994095818311 1 0.478727 0.526181 0.642077 0.30427 GeneID:254065,Genbank:NM_153252.4,HGNC:HGNC:17342,MIM:300553 bromodomain and WD repeat domain containing 3 BSCL2 1076.6655075068 983.008108382145 1170.32290663145 1.19055264819493 0.251631420364889 0.0994230218543862 1 17.262 17.9975 19.7792 21.4895 GeneID:26580,Genbank:NM_001122955.3,HGNC:HGNC:15832,MIM:606158 BSCL2, seipin lipid droplet biogenesis associated GO:0016042,GO:0019915,GO:0030176,GO:0034389,GO:0045444,GO:0050995 lipid catabolic process|lipid storage|integral component of endoplasmic reticulum membrane|lipid particle organization|fat cell differentiation|negative regulation of lipid catabolic process BSDC1 2091.90739382102 1943.43369765382 2240.38108998823 1.1527952266614 0.205136266921107 0.144018057136872 1 10.5095 10.5505 12.402 12.6662 GeneID:55108,Genbank:NM_001143890.2,HGNC:HGNC:25501,MIM:617518 BSD domain containing 1 BSG 26153.3737601583 25770.0549167494 26536.6926035672 1.0297491677567 0.0422929602204799 0.761708949091987 1 419.775 425.565 423.575 467.401 GeneID:682,Genbank:NM_198590.2,HGNC:HGNC:1116,MIM:109480 basigin (Ok blood group) BSN 9.94926684913358 11.6558524424989 8.2426812557683 0.707171036732958 -0.499868906721091 0.603903267621258 1 0.0215528 0.0325763 0.0298373 0.00933361 GeneID:8927,Genbank:NM_003458.3,HGNC:HGNC:1117,MIM:604020 bassoon presynaptic cytomatrix protein GO:0005634,GO:0007268,GO:0007416,GO:0009986,GO:0014069,GO:0030054,GO:0030424,GO:0030425,GO:0035418,GO:0044306,GO:0046872,GO:0048786,GO:0048788,GO:0060076,GO:0099526 nucleus|chemical synaptic transmission|synapse assembly|cell surface|postsynaptic density|cell junction|axon|dendrite|protein localization to synapse|neuron projection terminus|metal ion binding|presynaptic active zone|cytoskeleton of presynaptic active zone|excitatory synapse|presynapse to nucleus signaling pathway BSPRY 1.0012194055454 1.51824048055703 0.484198330533773 0.31892070902768 -1.64873031325362 0.791516662337547 1 0 0.0389411 0 0.0191432 GeneID:54836,Genbank:NM_001317943.1,HGNC:HGNC:18232 B-box and SPRY domain containing GO:0006816,GO:0008270,GO:0016020,GO:0031252,GO:0048471,GO:1990830 calcium ion transport|zinc ion binding|membrane|cell leading edge|perinuclear region of cytoplasm|cellular response to leukemia inhibitory factor BST1 4.45842813837101 4.55472144167109 4.36213483507094 0.957717149321543 -0.0623284593060362 1 1 0.0192444 0.0272401 0.0367838 0.0171249 GeneID:683,Genbank:XM_011513881.2,HGNC:HGNC:1118,MIM:600387 bone marrow stromal cell antigen 1 GO:0001931,GO:0001952,GO:0002691,GO:0003953,GO:0005576,GO:0005886,GO:0006501,GO:0006959,GO:0007165,GO:0008284,GO:0016740,GO:0016849,GO:0019674,GO:0019898,GO:0030890,GO:0031225,GO:0032956,GO:0035579,GO:0043312,GO:0050135,GO:0050727,GO:0050730,GO:0050848,GO:0061809,GO:0061811,GO:0061812,GO:0070062,GO:0090022,GO:0090322,GO:2001044 uropod|regulation of cell-matrix adhesion|regulation of cellular extravasation|NAD+ nucleosidase activity|extracellular region|plasma membrane|C-terminal protein lipidation|humoral immune response|signal transduction|positive regulation of cell proliferation|transferase activity|phosphorus-oxygen lyase activity|NAD metabolic process|extrinsic component of membrane|positive regulation of B cell proliferation|anchored component of membrane|regulation of actin cytoskeleton organization|specific granule membrane|neutrophil degranulation|NAD(P)+ nucleosidase activity|regulation of inflammatory response|regulation of peptidyl-tyrosine phosphorylation|regulation of calcium-mediated signaling|NAD+ nucleotidase, cyclic ADP-ribose generating|ADP-ribosyl cyclase activity|cyclic ADP-ribose hydrolase|extracellular exosome|regulation of neutrophil chemotaxis|regulation of superoxide metabolic process|regulation of integrin-mediated signaling pathway hsa00760,hsa04970,hsa04972 Nicotinate and nicotinamide metabolism|Salivary secretion|Pancreatic secretion BST2 3361.36863353256 2836.43541521264 3886.30185185247 1.37013585114933 0.454318945786285 0.355473159919096 1 113.105 124.613 222.425 113.956 GeneID:684,Genbank:NM_004335.3,HGNC:HGNC:1119,MIM:600534 bone marrow stromal cell antigen 2 GO:0002737,GO:0003723,GO:0004871,GO:0005771,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0006959,GO:0007267,GO:0007275,GO:0008191,GO:0008283,GO:0009615,GO:0009986,GO:0016020,GO:0016324,GO:0030308,GO:0030336,GO:0031225,GO:0032956,GO:0034341,GO:0035455,GO:0035456,GO:0035577,GO:0042113,GO:0042802,GO:0042803,GO:0043123,GO:0043312,GO:0045071,GO:0045087,GO:0045121,GO:0051607,GO:0060337,GO:0070062,GO:1901253 negative regulation of plasmacytoid dendritic cell cytokine production|RNA binding|signal transducer activity|multivesicular body|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|humoral immune response|cell-cell signaling|multicellular organism development|metalloendopeptidase inhibitor activity|cell proliferation|response to virus|cell surface|membrane|apical plasma membrane|negative regulation of cell growth|negative regulation of cell migration|anchored component of membrane|regulation of actin cytoskeleton organization|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|azurophil granule membrane|B cell activation|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|negative regulation of viral genome replication|innate immune response|membrane raft|defense response to virus|type I interferon signaling pathway|extracellular exosome|negative regulation of intracellular transport of viral material hsa05170 Human immunodeficiency virus 1 infection BTAF1 715.515090262636 739.838674463633 691.19150606164 0.934246248430767 -0.0981252295713564 0.767055961720062 1 3.55484 2.81912 3.55922 2.42015 GeneID:9044,Genbank:XM_011540326.2,HGNC:HGNC:17307,MIM:605191 B-TFIID TATA-box binding protein associated factor 1 GO:0003677,GO:0003700,GO:0004386,GO:0005524,GO:0005654,GO:0035562,GO:0043231,GO:0045892 DNA binding|DNA binding transcription factor activity|helicase activity|ATP binding|nucleoplasm|negative regulation of chromatin binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated BTBD1 3329.07643233285 3358.09626325588 3300.05660140981 0.982716498487212 -0.025152817912067 0.872310843051876 1 46.5362 43.601 49.5982 40.5428 GeneID:53339,Genbank:NM_001011885.1,HGNC:HGNC:1120,MIM:608530 BTB domain containing 1 GO:0000932,GO:0005829,GO:0019005,GO:0022008,GO:0030162,GO:0031625,GO:0042787,GO:0043161,GO:0043234,GO:0043393,GO:0043687 P-body|cytosol|SCF ubiquitin ligase complex|neurogenesis|regulation of proteolysis|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein complex|regulation of protein binding|post-translational protein modification BTBD10 559.996324238449 558.26740071515 561.725247761749 1.00619389031523 0.00890833461015643 0.962464662694816 1 4.24135 4.19717 4.78375 4.10078 GeneID:84280,Genbank:NM_001297741.1,HGNC:HGNC:21445,MIM:615933 BTB domain containing 10 GO:0001650,GO:0005634,GO:0005737,GO:0042327,GO:0044342,GO:1901215 fibrillar center|nucleus|cytoplasm|positive regulation of phosphorylation|type B pancreatic cell proliferation|negative regulation of neuron death BTBD11 61.1395726368314 67.5229752647834 54.7561700088794 0.810926500115843 -0.302356935961103 0.414503014038551 1 0.297202 0.344046 0.2323 0.309555 GeneID:121551,Genbank:XM_017018807.2,HGNC:HGNC:23844 BTB domain containing 11 GO:0005737,GO:0016021,GO:0019005,GO:0030162,GO:0031625,GO:0042787,GO:0043161,GO:0046982,GO:0060395 cytoplasm|integral component of membrane|SCF ubiquitin ligase complex|regulation of proteolysis|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein heterodimerization activity|SMAD protein signal transduction BTBD16 5.15364283380061 3.03648096111406 7.27080470648717 2.39448387775156 1.25971472182734 0.380869904257729 1 0.0110784 0.0102357 0.0524703 0.0490359 GeneID:118663,Genbank:XM_011539239.2,HGNC:HGNC:26340 BTB domain containing 16 GO:0000151,GO:0005634 ubiquitin ligase complex|nucleus BTBD18 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:643376,Genbank:XM_011545212.2,HGNC:HGNC:37214 BTB domain containing 18 GO:0005634,GO:0006351,GO:0007141,GO:0007283,GO:0010529,GO:0016567,GO:0030154,GO:0031463,GO:0032968,GO:1990511 nucleus|transcription, DNA-templated|male meiosis I|spermatogenesis|negative regulation of transposition|protein ubiquitination|cell differentiation|Cul3-RING ubiquitin ligase complex|positive regulation of transcription elongation from RNA polymerase II promoter|piRNA biosynthetic process BTBD19 71.7730360284868 72.3080194247712 71.2380526322024 0.985202653853878 -0.0215075808378689 0.996784472127499 1 0.707509 0.611547 0.74286 0.745292 GeneID:149478,Genbank:XM_017000447.1,HGNC:HGNC:27145 BTB domain containing 19 BTBD2 1687.01150215928 1380.76749697787 1993.25550734068 1.44358518845742 0.529656246014279 0.000259411519675579 0.0423952540726947 21.9283 23.7243 34.031 33.3291 GeneID:55643,Genbank:XM_011528127.1,HGNC:HGNC:15504,MIM:608531 BTB domain containing 2 GO:0000932,GO:0005829,GO:0019005,GO:0022008,GO:0030162,GO:0031625,GO:0042787,GO:0043161 P-body|cytosol|SCF ubiquitin ligase complex|neurogenesis|regulation of proteolysis|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process BTBD3 1528.80995373966 1515.47319558122 1542.14671189809 1.01760078396282 0.0251716871920933 0.846780167004421 1 13.6626 13.0773 14.6907 12.8332 GeneID:22903,Genbank:NM_181443.3,HGNC:HGNC:15854,MIM:615566 BTB domain containing 3 GO:0005634,GO:0005829,GO:0019005,GO:0021987,GO:0030162,GO:0031625,GO:0042787,GO:0043161,GO:0048813 nucleus|cytosol|SCF ubiquitin ligase complex|cerebral cortex development|regulation of proteolysis|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|dendrite morphogenesis BTBD6 1571.81920233918 1479.45109421237 1664.18731046599 1.12486807909792 0.169755816739263 0.245587271548639 1 31.9984 32.9414 37.6918 37.3103 GeneID:90135,Genbank:NM_033271.2,HGNC:HGNC:19897 BTB domain containing 6 GO:0005829,GO:0019005,GO:0022008,GO:0030162,GO:0031625,GO:0042787,GO:0043161,GO:0043687 cytosol|SCF ubiquitin ligase complex|neurogenesis|regulation of proteolysis|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification BTBD7 600.907263941676 641.03940736955 560.775120513803 0.87479040144333 -0.192990704252246 0.257357159392998 1 2.70853 2.58134 2.64458 1.98055 GeneID:55727,Genbank:NM_001289133.1,HGNC:HGNC:18269,MIM:610386 BTB domain containing 7 GO:0005634,GO:0007275,GO:0060693 nucleus|multicellular organism development|regulation of branching involved in salivary gland morphogenesis BTBD8 1.99993726140571 2.54640955915669 1.45346496365472 0.570789941636908 -0.808968182775871 0.825113498854447 1 0 0.0978086 0.0328847 0 GeneID:284697,Genbank:NM_183242.3,HGNC:HGNC:21019 BTB domain containing 8 GO:0000976,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0045893 transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-templated BTBD9 659.001373114373 623.464480483985 694.53826574476 1.11399813058412 0.155746811673204 0.335753773267829 1 2.05512 1.92546 2.50859 1.91465 GeneID:114781,Genbank:XM_011514279.3,HGNC:HGNC:21228,MIM:611237 BTB domain containing 9 GO:0005737,GO:0007616,GO:0008344,GO:0019005,GO:0030162,GO:0031625,GO:0042428,GO:0042748,GO:0042787,GO:0043161,GO:0048512,GO:0050804,GO:0050951,GO:0060586,GO:1900242 cytoplasm|long-term memory|adult locomotory behavior|SCF ubiquitin ligase complex|regulation of proteolysis|ubiquitin protein ligase binding|serotonin metabolic process|circadian sleep/wake cycle, non-REM sleep|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|circadian behavior|modulation of chemical synaptic transmission|sensory perception of temperature stimulus|multicellular organismal iron ion homeostasis|regulation of synaptic vesicle endocytosis BTC 42.3536179584994 35.7457863775636 48.9614495394353 1.36971247526301 0.453873080012914 0.41988080557931 1 0.201471 0.296122 0.593927 0.314194 GeneID:685,Genbank:NM_001316963.1,HGNC:HGNC:1121,MIM:600345 betacellulin GO:0000165,GO:0004713,GO:0005088,GO:0005154,GO:0005576,GO:0005615,GO:0005622,GO:0005886,GO:0007173,GO:0008083,GO:0008284,GO:0016021,GO:0035810,GO:0038128,GO:0043066,GO:0045597,GO:0045840,GO:0046934,GO:0048146,GO:0051781,GO:0051897,GO:1901185,GO:2000145 MAPK cascade|protein tyrosine kinase activity|Ras guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|extracellular region|extracellular space|intracellular|plasma membrane|epidermal growth factor receptor signaling pathway|growth factor activity|positive regulation of cell proliferation|integral component of membrane|positive regulation of urine volume|ERBB2 signaling pathway|negative regulation of apoptotic process|positive regulation of cell differentiation|positive regulation of mitotic nuclear division|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|positive regulation of fibroblast proliferation|positive regulation of cell division|positive regulation of protein kinase B signaling|negative regulation of ERBB signaling pathway|regulation of cell motility hsa04012 ErbB signaling pathway BTD 835.708838854954 796.649756471964 874.767921237945 1.0980583551697 0.134954726908532 0.401907979974319 1 2.13965 2.4002 2.63207 2.35703 GeneID:686,Genbank:NM_001281723.2,HGNC:HGNC:1122,MIM:609019 biotinidase GO:0005576,GO:0005615,GO:0005759,GO:0006768,GO:0007417,GO:0016810,GO:0047708,GO:0070062 extracellular region|extracellular space|mitochondrial matrix|biotin metabolic process|central nervous system development|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|biotinidase activity|extracellular exosome hsa00780,hsa04977 Biotin metabolism|Vitamin digestion and absorption BTF3 7438.84459709084 7971.54301321069 6906.14618097099 0.866349986386062 -0.206978135038387 0.116880452028638 1 205.196 200.71 174.162 183.805 GeneID:689,Genbank:NM_001037637.1,HGNC:HGNC:1125,MIM:602542 basic transcription factor 3 GO:0001701,GO:0003723,GO:0005634,GO:0005829,GO:0006355,GO:0006366,GO:0015031 in utero embryonic development|RNA binding|nucleus|cytosol|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|protein transport BTF3L4 1434.87706228064 1488.56831174911 1381.18581281217 0.927861893814761 -0.108018009293126 0.467130142496075 1 15.7298 15.9835 15.0756 14.5038 GeneID:91408,Genbank:NM_152265.4,HGNC:HGNC:30547 basic transcription factor 3 like 4 BTG1 1224.47048498618 1157.92131325793 1291.01965671443 1.11494593106851 0.156973748826553 0.29181869733415 1 11.7193 12.598 13.6781 13.5791 GeneID:694,Genbank:NM_001731.2,HGNC:HGNC:1130,MIM:109580 BTG anti-proliferation factor 1 hsa03018 RNA degradation BTG2 107.852831128992 88.2588446253006 127.446817632683 1.44401185143261 0.530082582898827 0.123922149031541 1 1.8182 1.0696 1.99103 2.24257 GeneID:7832,Genbank:NM_006763.2,HGNC:HGNC:1131,MIM:601597 BTG anti-proliferation factor 2 GO:0001078,GO:0005829,GO:0006281,GO:0006351,GO:0006479,GO:0006974,GO:0006977,GO:0008285,GO:0008306,GO:0009612,GO:0009952,GO:0014070,GO:0017148,GO:0021542,GO:0021954,GO:0031175,GO:0035914,GO:0043434,GO:0043524,GO:0051602,GO:0060213,GO:0070062,GO:2000178 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|cytosol|DNA repair|transcription, DNA-templated|protein methylation|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation|associative learning|response to mechanical stimulus|anterior/posterior pattern specification|response to organic cyclic compound|negative regulation of translation|dentate gyrus development|central nervous system neuron development|neuron projection development|skeletal muscle cell differentiation|response to peptide hormone|negative regulation of neuron apoptotic process|response to electrical stimulus|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|extracellular exosome|negative regulation of neural precursor cell proliferation hsa03018 RNA degradation BTG3 1133.8046435358 1193.16721957843 1074.44206749318 0.900495797959322 -0.151208550879512 0.31373604914246 1 17.6711 18.2329 17.3296 16.084 GeneID:10950,Genbank:NM_006806.4,HGNC:HGNC:1132,MIM:605674 BTG anti-proliferation factor 3 GO:0005737,GO:0008285,GO:0045930 cytoplasm|negative regulation of cell proliferation|negative regulation of mitotic cell cycle hsa03018 RNA degradation BTG4 1.80379780716536 2.15239070656922 1.45520490776151 0.676087711826734 -0.564717669077069 0.971494676615895 1 0.00980283 0 0.0283054 0 GeneID:54766,Genbank:XM_011542876.2,HGNC:HGNC:13862,MIM:605673 BTG anti-proliferation factor 4 GO:0007050,GO:0008285,GO:0030182,GO:0045930 cell cycle arrest|negative regulation of cell proliferation|neuron differentiation|negative regulation of mitotic cell cycle hsa03018 RNA degradation BTK 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0120565 0 0 0 GeneID:695,Genbank:NM_001287344.1,HGNC:HGNC:1133,MIM:300300 Bruton tyrosine kinase hsa04064,hsa04380,hsa04611,hsa04662,hsa04664,hsa05169,hsa05340 NF-kappa B signaling pathway|Osteoclast differentiation|Platelet activation|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Epstein-Barr virus infection|Primary immunodeficiency BTLA 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.00968921 0.0096326 0 GeneID:151888,Genbank:XM_011512447.3,HGNC:HGNC:21087,MIM:607925 B and T lymphocyte associated GO:0002250,GO:0005886,GO:0016021,GO:0031295 adaptive immune response|plasma membrane|integral component of membrane|T cell costimulation BTN1A1 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.00997352 0 0.00950773 GeneID:696,Genbank:XM_005249340.3,HGNC:HGNC:1135,MIM:601610 butyrophilin subfamily 1 member A1 GO:0004872,GO:0005615,GO:0005886,GO:0005887 receptor activity|extracellular space|plasma membrane|integral component of plasma membrane BTN2A1 1658.77758292231 1724.5189108055 1593.03625503913 0.923756906959659 -0.114414848511719 0.431674944144667 1 14.2319 13.5305 14.1018 11.9668 GeneID:11120,Genbank:NM_001197234.2,HGNC:HGNC:1136,MIM:613590 butyrophilin subfamily 2 member A1 GO:0005886,GO:0005887,GO:0006629,GO:0070062 plasma membrane|integral component of plasma membrane|lipid metabolic process|extracellular exosome BTN2A2 766.756636353189 776.565620645966 756.947652060413 0.974737526277259 -0.0369143073245546 0.835147405470743 1 5.43471 5.11681 5.15272 5.5702 GeneID:10385,Genbank:XM_011514231.3,HGNC:HGNC:1137,MIM:613591 butyrophilin subfamily 2 member A2 GO:0005886,GO:0016021,GO:0031324,GO:0046007,GO:0050710,GO:0070062 plasma membrane|integral component of membrane|negative regulation of cellular metabolic process|negative regulation of activated T cell proliferation|negative regulation of cytokine secretion|extracellular exosome BTN3A1 344.143357555089 309.710232377671 378.576482732507 1.22235703943697 0.289665744886524 0.460228028010706 1 2.02322 2.42056 3.50899 2.0671 GeneID:11119,Genbank:NM_001145009.1,HGNC:HGNC:1138,MIM:613593 butyrophilin subfamily 3 member A1 GO:0002250,GO:0005886,GO:0016021,GO:0050663,GO:0050798,GO:0050852,GO:0072643 adaptive immune response|plasma membrane|integral component of membrane|cytokine secretion|activated T cell proliferation|T cell receptor signaling pathway|interferon-gamma secretion BTN3A2 592.562944356413 549.245218726924 635.880669985902 1.15773546733786 0.211305647491886 0.218990508684979 1 3.52243 4.07565 4.92557 3.89416 GeneID:11118,Genbank:NM_001197247.2,HGNC:HGNC:1139,MIM:613594 butyrophilin subfamily 3 member A2 GO:0002456,GO:0005886,GO:0016020,GO:0016021,GO:0072643 T cell mediated immunity|plasma membrane|membrane|integral component of membrane|interferon-gamma secretion BTN3A3 233.791481898219 183.052313610318 284.530650186121 1.55436795402559 0.63632806269767 0.0893334784145072 0.978485089907035 2.16509 1.68939 3.73753 2.43269 GeneID:10384,Genbank:NM_006994.4,HGNC:HGNC:1140,MIM:613595 butyrophilin subfamily 3 member A3 GO:0002456,GO:0005886,GO:0016020,GO:0016021 T cell mediated immunity|plasma membrane|membrane|integral component of membrane BTRC 661.192543085852 649.178516104085 673.206570067619 1.03701301470624 0.0524340003558863 0.745524236858151 1 3.20169 3.17972 3.83727 2.9661 GeneID:8945,Genbank:XM_017016872.1,HGNC:HGNC:1144,MIM:603482 beta-transducin repeat containing E3 ubiquitin protein ligase hsa04114,hsa04120,hsa04218,hsa04310,hsa04340,hsa04390,hsa04710,hsa05131,hsa05170 Oocyte meiosis|Ubiquitin mediated proteolysis|Cellular senescence|Wnt signaling pathway|Hedgehog signaling pathway|Hippo signaling pathway|Circadian rhythm|Shigellosis|Human immunodeficiency virus 1 infection BUB1 1829.99959431283 1853.63292723433 1806.36626139134 0.974500525347535 -0.0372651316555264 0.884788131000467 1 17.3248 14.6843 17.9344 14.0609 GeneID:699,Genbank:NM_001278616.1,HGNC:HGNC:1148,MIM:602452 BUB1 mitotic checkpoint serine/threonine kinase hsa04110,hsa04114,hsa04914 Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation BUB1B 2416.18253557076 2549.72301075652 2282.642060385 0.895250994227692 -0.159635879144898 0.266685288335738 1 24.2968 21.318 21.4059 19.6356 GeneID:701,Genbank:NM_001211.5,HGNC:HGNC:1149,MIM:602860 BUB1 mitotic checkpoint serine/threonine kinase B hsa04110,hsa05166 Cell cycle|Human T-cell leukemia virus 1 infection BUB1B-PAK6 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0.871921 0.932544 0.297258 0.406079 GeneID:106821730,Genbank:NM_001128628.2,HGNC:HGNC:52276 BUB1B-PAK6 readthrough hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05170,hsa05211 ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection|Renal cell carcinoma BUB3 4128.78737474408 4378.15769308805 3879.41705640012 0.886084359758144 -0.174484037629582 0.195963296883094 1 68.9956 67.6065 61.7324 59.6636 GeneID:9184,Genbank:NM_004725.3,HGNC:HGNC:1151,MIM:603719 BUB3, mitotic checkpoint protein GO:0000070,GO:0000776,GO:0000777,GO:0005654,GO:0007094,GO:0008608,GO:0033597,GO:0043130,GO:0051301,GO:0051321,GO:0051983,GO:1990298 mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|nucleoplasm|mitotic spindle assembly checkpoint|attachment of spindle microtubules to kinetochore|mitotic checkpoint complex|ubiquitin binding|cell division|meiotic cell cycle|regulation of chromosome segregation|bub1-bub3 complex hsa04110,hsa05166 Cell cycle|Human T-cell leukemia virus 1 infection BUD13 590.437720124514 562.485938234026 618.389502015001 1.09938659792366 0.136698797416335 0.420042317063678 1 4.92824 5.28171 5.78121 5.31148 GeneID:84811,Genbank:NM_001159736.1,HGNC:HGNC:28199 BUD13 homolog GO:0000398,GO:0003723,GO:0005634,GO:0006406,GO:0070274 mRNA splicing, via spliceosome|RNA binding|nucleus|mRNA export from nucleus|RES complex BUD23 2996.68962839605 3171.53127394102 2821.84798285108 0.889743073333969 -0.168539298515753 0.211377461761854 1 58.4391 62.1632 55.9405 58.4514 GeneID:114049,Genbank:NM_001202560.2,HGNC:HGNC:16405,MIM:615733 BUD23, rRNA methyltransferase and ribosome maturation factor GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0006355,GO:0008168,GO:0016435,GO:0016569,GO:0031167,GO:0046982,GO:0048471,GO:0070476,GO:2000234 RNA binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|methyltransferase activity|rRNA (guanine) methyltransferase activity|covalent chromatin modification|rRNA methylation|protein heterodimerization activity|perinuclear region of cytoplasm|rRNA (guanine-N7)-methylation|positive regulation of rRNA processing BUD31 2354.37523233338 2416.12293347177 2292.62753119499 0.948886954150413 -0.0756918731848428 0.583654192519956 1 22.0442 21.694 19.8211 22.1177 GeneID:8896,Genbank:XM_005250674.3,HGNC:HGNC:29629,MIM:603477 BUD31 homolog GO:0000398,GO:0003700,GO:0005634,GO:0005654,GO:0005681,GO:0006357,GO:0030374,GO:0035257,GO:2000825 mRNA splicing, via spliceosome|DNA binding transcription factor activity|nucleus|nucleoplasm|spliceosomal complex|regulation of transcription from RNA polymerase II promoter|ligand-dependent nuclear receptor transcription coactivator activity|nuclear hormone receptor binding|positive regulation of androgen receptor activity hsa03040 Spliceosome BVES 2565.28215086531 2664.51335467242 2466.0509470582 0.925516452275912 -0.111669458755962 0.563215320718251 1 19.8233 17.8393 20.1193 15.1506 GeneID:11149,Genbank:NM_001199563.1,HGNC:HGNC:1152,MIM:604577 blood vessel epicardial substance GO:0001921,GO:0002027,GO:0002244,GO:0002931,GO:0005198,GO:0005886,GO:0005901,GO:0005923,GO:0007507,GO:0007517,GO:0007519,GO:0008360,GO:0016021,GO:0016192,GO:0016328,GO:0030054,GO:0030552,GO:0031253,GO:0034446,GO:0040017,GO:0042383,GO:0042391,GO:0043087,GO:0048278,GO:0060931,GO:0060973,GO:0090136,GO:2001135 positive regulation of receptor recycling|regulation of heart rate|hematopoietic progenitor cell differentiation|response to ischemia|structural molecule activity|plasma membrane|caveola|bicellular tight junction|heart development|muscle organ development|skeletal muscle tissue development|regulation of cell shape|integral component of membrane|vesicle-mediated transport|lateral plasma membrane|cell junction|cAMP binding|cell projection membrane|substrate adhesion-dependent cell spreading|positive regulation of locomotion|sarcolemma|regulation of membrane potential|regulation of GTPase activity|vesicle docking|sinoatrial node cell development|cell migration involved in heart development|epithelial cell-cell adhesion|regulation of endocytic recycling hsa04530 Tight junction BYSL 1440.50750379147 1576.96549454677 1304.04951303617 0.826935984043808 -0.274152445148879 0.116601996673984 1 29.0504 33.3391 24.9281 27.6004 GeneID:705,Genbank:NM_004053.3,HGNC:HGNC:1157,MIM:603871 bystin like GO:0000462,GO:0001829,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0007155,GO:0007565,GO:0008283,GO:0016020,GO:0043231,GO:0045177 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|trophectodermal cell differentiation|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|cell adhesion|female pregnancy|cell proliferation|membrane|intracellular membrane-bounded organelle|apical part of cell BZW1 2138.49488598487 2255.49416648849 2021.49560548125 0.89625397197478 -0.158020487392909 0.274921691724509 1 24.7402 21.599 21.8674 19.3571 GeneID:9689,Genbank:NM_001207067.1,HGNC:HGNC:18380 basic leucine zipper and W2 domains 1 GO:0003723,GO:0005737,GO:0006351,GO:0006355,GO:0016020,GO:0045296 RNA binding|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|membrane|cadherin binding BZW2 2560.70507957746 2750.71012048883 2370.70003866608 0.861850189522983 -0.214490979187338 0.119945728159286 1 47.6244 48.75 40.4398 42.7889 GeneID:28969,Genbank:NM_001159767.1,HGNC:HGNC:18808 basic leucine zipper and W2 domains 2 GO:0005737,GO:0007399,GO:0016020,GO:0030154,GO:0045296 cytoplasm|nervous system development|membrane|cell differentiation|cadherin binding C10orf111 5.23525345854171 5.14084539299833 5.32966152408509 1.03672861497526 0.0520382884907098 1 1 0.0927792 0.113945 0.0586335 0.136805 GeneID:221060,Genbank:NM_153244.1,HGNC:HGNC:28582 chromosome 10 open reading frame 111 GO:0016021 integral component of membrane C10orf126 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0176523 0 GeneID:283080,Genbank:NM_001278522.1,HGNC:HGNC:28693 chromosome 10 open reading frame 126 C10orf143 24.4248327143003 18.8050097180116 30.044655710589 1.597694240052 0.675991337823044 0.254906696669813 1 0.148595 0.158659 0.382663 0.414007 GeneID:387723,Genbank:XM_024448009.1,HGNC:HGNC:48677 chromosome 10 open reading frame 143 C10orf25 37.5055352541291 37.2061919283278 37.8048785799304 1.01609104884359 0.0230296834385747 0.974542865345498 1 0.551937 0.411231 0.570108 0.440982 GeneID:220979,Genbank:XM_017015895.1,HGNC:HGNC:23509 chromosome 10 open reading frame 25 GO:0005576 extracellular region C10orf55 405.29173544311 480.615605142678 329.967865743543 0.68655254264078 -0.542557959210441 0.107953610695771 1 0.592928 0.408568 0.629259 0.707989 GeneID:414236,Genbank:NM_001001791.2,HGNC:HGNC:31008 chromosome 10 open reading frame 55 C10orf62 1.7784797117428 2.10436443188427 1.45259499160132 0.690277296837148 -0.534752059943747 0.969269437705094 1 0.0909056 0.0269978 0 0.0794328 GeneID:414157,Genbank:NM_001009997.2,HGNC:HGNC:23294 chromosome 10 open reading frame 62 C10orf67 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.00424114 0.00407711 0 0 GeneID:256815,Genbank:XM_017016029.1,HGNC:HGNC:28716 chromosome 10 open reading frame 67 GO:0005739 mitochondrion C10orf82 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0 0 0 0 GeneID:143379,Genbank:XM_011539342.2,HGNC:HGNC:28500 chromosome 10 open reading frame 82 C10orf88 232.002954296001 232.356403108417 231.649505483585 0.996957701120456 -0.00439579957011524 1 1 3.35156 2.93653 3.17061 3.11191 GeneID:80007,Genbank:NM_024942.3,HGNC:HGNC:25822 chromosome 10 open reading frame 88 GO:0042802 identical protein binding C10orf90 31.0157844554097 33.4395081918316 28.5920607189877 0.855038314408344 -0.225939026036862 0.686684640403683 1 0.228475 0.204506 0.171984 0.167412 GeneID:118611,Genbank:NM_001350922.1,HGNC:HGNC:26563,MIM:617735 chromosome 10 open reading frame 90 GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0015629,GO:0042826,GO:0051393 nucleoplasm|cytoplasm|centrosome|cytosol|plasma membrane|actin cytoskeleton|histone deacetylase binding|alpha-actinin binding C10orf95 4.14981351209502 1.51824048055703 6.78138654363301 4.46660896641682 2.15917995804284 0.214076032115441 1 0 0 0.108532 0.455621 GeneID:79946,Genbank:NM_024886.2,HGNC:HGNC:25880 chromosome 10 open reading frame 95 C11orf1 129.552425717445 125.850263751963 133.254587682928 1.0588343934309 0.0824769628344226 0.831965305842566 1 2.32887 3.04615 2.78594 3.59651 GeneID:64776,Genbank:NM_022761.2,HGNC:HGNC:1163 chromosome 11 open reading frame 1 GO:0005634,GO:0005654 nucleus|nucleoplasm C11orf16 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0.0167385 0.0150725 0 0 GeneID:56673,Genbank:NM_020643.2,HGNC:HGNC:1169 chromosome 11 open reading frame 16 C11orf21 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0 0 0 0.0128788 GeneID:29125,Genbank:NM_001329958.1,HGNC:HGNC:13231,MIM:611033 chromosome 11 open reading frame 21 GO:0005737 cytoplasm C11orf24 753.40345844832 713.473922309869 793.332994586771 1.11192991051216 0.153065851961245 0.354133958911687 1 8.27435 8.89438 9.95281 9.27099 GeneID:53838,Genbank:NM_001300913.1,HGNC:HGNC:1174,MIM:610880 chromosome 11 open reading frame 24 GO:0005794,GO:0005886,GO:0016021 Golgi apparatus|plasma membrane|integral component of membrane C11orf42 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00668246 0 0 0.00593745 GeneID:160298,Genbank:XM_011519926.3,HGNC:HGNC:28541 chromosome 11 open reading frame 42 C11orf44 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.0115374 0 GeneID:283171,Genbank:NM_001271983.1,HGNC:HGNC:26805 chromosome 11 open reading frame 44 GO:0005576 extracellular region C11orf45 88.4701404782458 90.1809126135531 86.7593683429385 0.962059107948078 -0.0558025604305913 0.893797772038356 1 1.02406 0.843596 1.11019 0.814384 GeneID:219833,Genbank:XM_011542654.2,HGNC:HGNC:28584 chromosome 11 open reading frame 45 GO:0005576 extracellular region C11orf49 939.247025604588 823.478205064926 1055.01584614425 1.28117033293075 0.357462296240201 0.021318667938126 0.598036670329243 4.77065 5.26042 6.4013 6.41101 GeneID:79096,Genbank:XM_011520364.2,HGNC:HGNC:28720 chromosome 11 open reading frame 49 C11orf52 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0401586 0 0 0 GeneID:91894,Genbank:NM_080659.2,HGNC:HGNC:30531 chromosome 11 open reading frame 52 GO:0070062 extracellular exosome C11orf54 224.363894933161 232.116271734992 216.611518131329 0.933202642418087 -0.0997377024837315 0.673384468025659 1 1.44147 1.35154 1.20726 1.38935 GeneID:28970,Genbank:NM_001351986.1,HGNC:HGNC:30204,MIM:615810 chromosome 11 open reading frame 54 GO:0005634,GO:0005654,GO:0008270,GO:0016604,GO:0016788,GO:0070062 nucleus|nucleoplasm|zinc ion binding|nuclear body|hydrolase activity, acting on ester bonds|extracellular exosome C11orf58 1978.77258794051 2125.22446846466 1832.32070741636 0.862177494474314 -0.213943190726398 0.137842110118174 1 12.231 11.1367 10.1708 10.4411 GeneID:10944,Genbank:NM_014267.5,HGNC:HGNC:16990 chromosome 11 open reading frame 58 C11orf65 1.99743571172061 2.05633815719933 1.93853326624189 0.942711323745559 -0.0851120372001571 1 1 0.0089416 0.0087985 0 0 GeneID:160140,Genbank:NM_001330368.1,HGNC:HGNC:28519 chromosome 11 open reading frame 65 C11orf68 762.991159643185 729.281685687199 796.700633599172 1.09244568900485 0.127561557848507 0.531034772611666 1 18.1101 22.4604 22.4323 23.6758 GeneID:83638,Genbank:NM_031450.3,HGNC:HGNC:28801 chromosome 11 open reading frame 68 GO:0003723 RNA binding C11orf71 137.230095030566 132.461323350833 141.998866710298 1.0720024767849 0.100308239043037 0.74226411361943 1 2.67407 3.76212 3.63427 3.32165 GeneID:54494,Genbank:NM_019021.3,HGNC:HGNC:25937 chromosome 11 open reading frame 71 C11orf74 154.086499572444 162.306635594692 145.866363550195 0.898708564907032 -0.154074743473023 0.551428822495106 1 2.61104 2.59227 2.49089 2.20472 GeneID:119710,Genbank:XM_011519885.3,HGNC:HGNC:25142 chromosome 11 open reading frame 74 GO:0005929 cilium C11orf80 387.096128757295 389.897611853337 384.294645661252 0.985629647318301 -0.0208824425519919 0.910630476844964 1 4.89973 5.07081 5.31849 5.66845 GeneID:79703,Genbank:NM_024650.3,HGNC:HGNC:26197,MIM:616109 chromosome 11 open reading frame 80 GO:0005694,GO:0007131,GO:0042138 chromosome|reciprocal meiotic recombination|meiotic DNA double-strand break formation C11orf86 5.2424314880454 6.12098819691306 4.36387477917774 0.712936316619354 -0.488154881893856 0.763642952399073 1 0.186208 0.28136 0.215074 0.0402642 GeneID:254439,Genbank:NM_001353554.1,HGNC:HGNC:34442 chromosome 11 open reading frame 86 C11orf87 10.001861237162 12.7320477957835 7.27167467854057 0.571131588191866 -0.808104915392946 0.388312842972202 1 0.040029 0.0672665 0.048131 0.0224413 GeneID:399947,Genbank:NM_207645.3,HGNC:HGNC:33788 chromosome 11 open reading frame 87 GO:0016021 integral component of membrane C11orf88 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0 0 0 0 GeneID:399949,Genbank:NM_207430.2,HGNC:HGNC:25061 chromosome 11 open reading frame 88 C11orf91 4.91654676790392 4.01662376502878 5.81646977077905 1.44809922737122 0.53416046287112 0.774640090060614 1 0 0.200438 0.140778 0.0328898 GeneID:100131378,Genbank:NM_001166692.1,HGNC:HGNC:34444 chromosome 11 open reading frame 91 C11orf94 7.20791442734155 6.65908587355536 7.75674298112774 1.16483600428272 0.220126854053573 0.907898425237497 1 0 0 0.2769 0 GeneID:143678,Genbank:NM_001080446.2,HGNC:HGNC:37213 chromosome 11 open reading frame 94 GO:0005576 extracellular region C11orf95 365.830244573767 347.838732180121 383.821756967413 1.1034474354301 0.14201790605564 0.461577427138561 1 3.0953 3.16889 3.53007 3.52596 GeneID:65998,Genbank:NM_001144936.1,HGNC:HGNC:28449,MIM:615699 chromosome 11 open reading frame 95 GO:0003676 nucleic acid binding C11orf96 19.8974004714299 15.5666150030498 24.22818593981 1.55641967987666 0.638231127444069 0.314163448055368 1 1.3765 0.748099 1.30866 1.87018 GeneID:387763,Genbank:NM_001145033.1,HGNC:HGNC:38675 chromosome 11 open reading frame 96 C11orf98 5.49453685205267 8.08127380474251 2.90779989936283 0.359819499947692 -1.47465472120648 0.262937918485212 1 59.4418 63.672 48.548 62.5969 GeneID:102288414,Genbank:NM_001286086.1,HGNC:HGNC:51238 chromosome 11 open reading frame 98 C12orf10 721.81205754717 763.210248280133 680.413866814208 0.89151563196052 -0.165668000397492 0.29646962307313 1 23.4452 23.532 21.5765 21.5435 GeneID:60314,Genbank:NM_021640.3,HGNC:HGNC:17590,MIM:611366 chromosome 12 open reading frame 10 GO:0005634,GO:0005654,GO:0005739,GO:0035641,GO:0043473,GO:0070062 nucleus|nucleoplasm|mitochondrion|locomotory exploration behavior|pigmentation|extracellular exosome C12orf29 316.454541039473 354.256669679397 278.65241239955 0.786583390657772 -0.346328371953415 0.0855524018881133 0.964561165794104 5.33247 4.56627 3.61322 3.83937 GeneID:91298,Genbank:NM_001009894.2,HGNC:HGNC:25322 chromosome 12 open reading frame 29 GO:0002244 hematopoietic progenitor cell differentiation C12orf4 293.156483412861 310.065016609827 276.247950215896 0.89093556324516 -0.166607002027179 0.421245563398571 1 2.24715 2.05333 2.09958 1.82905 GeneID:57102,Genbank:NM_001352962.1,HGNC:HGNC:1184,MIM:616082 chromosome 12 open reading frame 4 GO:0005737,GO:0043304 cytoplasm|regulation of mast cell degranulation C12orf42 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00603787 0 0 0 GeneID:374470,Genbank:XM_017019281.1,HGNC:HGNC:24729 chromosome 12 open reading frame 42 C12orf43 482.826753133444 507.214748018177 458.438758248711 0.903835623944203 -0.145867674109039 0.403390123518944 1 4.89373 5.08675 4.67483 4.69117 GeneID:64897,Genbank:NM_001286197.1,HGNC:HGNC:25719 chromosome 12 open reading frame 43 C12orf45 100.667245386175 116.039027057707 85.295463714643 0.735058418511426 -0.444069182696761 0.136813667690236 1 7.92798 7.96351 5.52441 5.70823 GeneID:121053,Genbank:NM_152318.2,HGNC:HGNC:28628 chromosome 12 open reading frame 45 C12orf49 1455.38763785013 1436.53551624822 1474.23975945205 1.02624664881401 0.0373775109216706 0.792040759462977 1 12.5194 12.0742 13.1491 12.5136 GeneID:79794,Genbank:NM_001353625.1,HGNC:HGNC:26128 chromosome 12 open reading frame 49 GO:0005576 extracellular region C12orf56 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0191972 0 0 0 GeneID:115749,Genbank:NM_001099676.2,HGNC:HGNC:26967 chromosome 12 open reading frame 56 C12orf57 1888.12672471507 1992.06847030889 1784.18497912124 0.895644404654716 -0.159002038350416 0.505586527732244 1 61.2603 77.1179 58.8501 72.4889 GeneID:113246,Genbank:NM_001301836.1,HGNC:HGNC:29521,MIM:615140 chromosome 12 open reading frame 57 GO:0005737,GO:0009791,GO:0014819,GO:0016607,GO:0021540,GO:0021678,GO:0036343,GO:0048593,GO:0050890 cytoplasm|post-embryonic development|regulation of skeletal muscle contraction|nuclear speck|corpus callosum morphogenesis|third ventricle development|psychomotor behavior|camera-type eye morphogenesis|cognition C12orf60 10.1900610563204 11.6558524424989 8.72426967014188 0.748488342073719 -0.417948248828669 0.666482054514053 1 0.0735955 0.119108 0.0401578 0.0467203 GeneID:144608,Genbank:XM_024448858.1,HGNC:HGNC:28726 chromosome 12 open reading frame 60 C12orf65 424.421420045078 440.796377071147 408.046463019009 0.925702851122 -0.11137892949096 0.551743239096586 1 4.07271 4.17469 3.94657 3.98194 GeneID:91574,Genbank:NM_152269.4,HGNC:HGNC:26784,MIM:613541 chromosome 12 open reading frame 65 GO:0004045,GO:0005739,GO:0005762,GO:0016150,GO:0070126,GO:0072344 aminoacyl-tRNA hydrolase activity|mitochondrion|mitochondrial large ribosomal subunit|translation release factor activity, codon nonspecific|mitochondrial translational termination|rescue of stalled ribosome C12orf66 79.4012786485617 84.1559769660099 74.6465803311136 0.887002718312722 -0.172989569064209 0.649815543074955 1 1.08676 0.834598 1.00425 0.690487 GeneID:144577,Genbank:NM_001300940.1,HGNC:HGNC:26517,MIM:617420 chromosome 12 open reading frame 66 GO:0005765,GO:0034198,GO:0042149,GO:0061462,GO:0140007,GO:1904262 lysosomal membrane|cellular response to amino acid starvation|cellular response to glucose starvation|protein localization to lysosome|KICSTOR complex|negative regulation of TORC1 signaling C12orf73 243.287056871125 273.368513393672 213.205600348578 0.77992010748343 -0.358601748400577 0.11785746739102 1 1.91138 2.31763 1.44484 1.80714 GeneID:728568,Genbank:NM_001135570.1,HGNC:HGNC:34450 chromosome 12 open reading frame 73 GO:0005576 extracellular region C12orf75 1497.62072090902 1445.40584475899 1549.83559705905 1.07224943269651 0.100640552675596 0.49528885025106 1 54.4652 58.7204 62.6952 60.0268 GeneID:387882,Genbank:NM_001145199.1,HGNC:HGNC:35164 chromosome 12 open reading frame 75 C12orf76 46.7389569070143 51.3222100357214 42.1557037783071 0.821392994357917 -0.283855452230963 0.492828865793933 1 0.790768 1.124 0.61315 0.58816 GeneID:400073,Genbank:NM_207435.2,HGNC:HGNC:33790 chromosome 12 open reading frame 76 C12orf80 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0 0 0.0320364 0 GeneID:283403,Genbank:NM_001242696.1,HGNC:HGNC:27473 chromosome 12 open reading frame 80 C13orf42 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0140546 0 0 0 GeneID:647166,Genbank:XM_024449398.1,HGNC:HGNC:42693 chromosome 13 open reading frame 42 C13orf46 5.3973735766992 3.52655236307142 7.26819479032697 2.06099159803679 1.04333862351115 0.464929437665758 1 0.00967053 0.0167343 0.0533328 0.025011 GeneID:100507747,Genbank:XM_017020909.1,HGNC:HGNC:53786 chromosome 13 open reading frame 46 C14orf119 856.873272711092 872.012857167211 841.733688254973 0.965276694416409 -0.0509855479013731 0.752323104443586 1 8.85364 8.59853 8.0044 8.98359 GeneID:55017,Genbank:NM_017924.3,HGNC:HGNC:20270 chromosome 14 open reading frame 119 GO:0005739,GO:0005829 mitochondrion|cytosol C14orf132 320.969055750613 288.147090691547 353.791020809678 1.22781396112863 0.296091979527348 0.132335421638125 1 1.2145 1.27054 1.68032 1.49785 GeneID:56967,Genbank:NM_001289139.1,HGNC:HGNC:20346 chromosome 14 open reading frame 132 GO:0016021 integral component of membrane C14orf178 9.61284548394474 12.9241528945232 6.30153807336622 0.487578421951088 -1.03629381477214 0.287254300177225 1 0.0785536 0.069644 0.0719749 0 GeneID:283579,Genbank:NM_174943.3,HGNC:HGNC:26385 chromosome 14 open reading frame 178 C14orf28 20.9303913234981 27.8085913968759 14.0521912501202 0.505318340277344 -0.984735552083681 0.11805850704057 1 0.389855 0.351463 0.132103 0.184121 GeneID:122525,Genbank:NM_001017923.1,HGNC:HGNC:19834 chromosome 14 open reading frame 28 C14orf93 169.002550426551 159.174102084209 178.830998768894 1.12349305840146 0.167991210729904 0.490425664645985 1 1.24461 1.17506 1.34625 1.46869 GeneID:60686,Genbank:NM_001130708.2,HGNC:HGNC:20162 chromosome 14 open reading frame 93 GO:0003723,GO:0005576 RNA binding|extracellular region C15orf32 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 1.61916e-08 2.57557e-08 0.0176644 1.06987e-08 GeneID:145858,Genbank:XM_011521257.2,HGNC:HGNC:26549 chromosome 15 open reading frame 32 C15orf39 621.693246863952 632.257356754749 611.129136973155 0.966582880284635 -0.0490346523120642 0.769697108043715 1 6.04318 5.71066 6.05993 5.61741 GeneID:56905,Genbank:NM_015492.4,HGNC:HGNC:24497 chromosome 15 open reading frame 39 GO:0005829 cytosol C15orf40 415.627153234304 433.416897077318 397.83740939129 0.9179093202735 -0.123576457210688 0.50182305168418 1 2.78701 2.8611 2.60744 2.68152 GeneID:123207,Genbank:XM_011521213.2,HGNC:HGNC:28443 chromosome 15 open reading frame 40 C15orf41 152.970760932058 161.038335142668 144.903186721447 0.899805543773624 -0.152314839383966 0.551182350880862 1 1.24818 1.41156 1.20669 0.987915 GeneID:84529,Genbank:NM_001321757.1,HGNC:HGNC:26929,MIM:615626 chromosome 15 open reading frame 41 C15orf48 3.42775751008625 2.00831188251439 4.84720313765811 2.4135709099074 1.27116921330373 0.512578245526723 1 0.0669382 0.126363 0.256934 0.119293 GeneID:84419,Genbank:NM_032413.3,HGNC:HGNC:29898,MIM:608409 chromosome 15 open reading frame 48 GO:0005634,GO:0005751,GO:0022900,GO:1902600 nucleus|mitochondrial respiratory chain complex IV|electron transport chain|hydrogen ion transmembrane transport C15orf56 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0.0231209 0.0490223 0 GeneID:644809,Genbank:NM_001039905.2,HGNC:HGNC:33868 chromosome 15 open reading frame 56 C15orf59 1.47997965068228 0.538097676642304 2.42186162472226 4.50078439259304 2.1701764549285 0.55105548931329 1 0.00691452 0 0 0.0241148 GeneID:388135,Genbank:XM_005254369.4,HGNC:HGNC:33753,MIM:617128 chromosome 15 open reading frame 59 C15orf61 157.41329510266 153.466750050099 161.359840155222 1.0514319232182 0.0723554433032108 0.84320383693435 1 5.03115 6.85048 5.15868 7.20071 GeneID:145853,Genbank:NM_001143936.1,HGNC:HGNC:34453 chromosome 15 open reading frame 61 GO:0005576 extracellular region C15orf62 18.858269356415 15.422536178995 22.2940025338351 1.44554710555316 0.531615622194866 0.429885099714332 1 0.238836 0.211663 0.340917 0.304382 GeneID:643338,Genbank:NM_001130448.2,HGNC:HGNC:34489 chromosome 15 open reading frame 62 GO:0005096,GO:0005737,GO:0005739,GO:0005886,GO:0007266,GO:0008360,GO:0017049,GO:0030838,GO:0031274 GTPase activator activity|cytoplasm|mitochondrion|plasma membrane|Rho protein signal transduction|regulation of cell shape|GTP-Rho binding|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly C15orf65 23.2613977303171 24.2340127591196 22.2887827015147 0.919731409034896 -0.12071548527023 0.884441984640616 1 1.41726 1.22457 0.925017 1.34907 GeneID:145788,Genbank:NM_001198784.1,HGNC:HGNC:44654 chromosome 15 open reading frame 65 C16orf45 232.845177728125 219.009822396837 246.680533059413 1.12634461029989 0.171648294121148 0.432720734625024 1 1.99902 1.95524 2.30331 2.08097 GeneID:89927,Genbank:NM_033201.2,HGNC:HGNC:19213 chromosome 16 open reading frame 45 GO:0007026,GO:0015630,GO:0021822 negative regulation of microtubule depolymerization|microtubule cytoskeleton|negative regulation of cell motility involved in cerebral cortex radial glia guided migration C16orf46 47.7094426325939 55.1947549766953 40.2241302884924 0.728767258872263 -0.456469949857815 0.326244772176004 1 0.468256 0.774916 0.527536 0.49269 GeneID:123775,Genbank:NM_001100873.1,HGNC:HGNC:26525 chromosome 16 open reading frame 46 GO:0005634,GO:0005654,GO:0005829 nucleus|nucleoplasm|cytosol C16orf47 0.97133319677934 0.490071401957362 1.45259499160132 2.96404765876891 1.56756864484914 0.837512515494886 1 0 0 0 0.0108206 GeneID:388289,Genbank:XM_024450275.1,HGNC:HGNC:28329 chromosome 16 open reading frame 47 C16orf54 0.968396661067546 0 1.93679332213509 Inf Inf 0.496080204589898 1 0 0 0 0.0580798 GeneID:283897,Genbank:NM_175900.3,HGNC:HGNC:26649 chromosome 16 open reading frame 54 GO:0016021 integral component of membrane C16orf58 1303.08909375584 1233.74709339152 1372.43109412016 1.11240877605426 0.153687031602358 0.304285509110848 1 17.9516 18.0389 20.0416 20.259 GeneID:64755,Genbank:NM_022744.3,HGNC:HGNC:25848 chromosome 16 open reading frame 58 GO:0016020,GO:0016021 membrane|integral component of membrane C16orf70 599.632921795904 667.175870806706 532.089972785102 0.797525804015863 -0.32639689673278 0.054427348317085 0.850412673568737 5.93615 5.4772 4.38791 4.74392 GeneID:80262,Genbank:XM_017023730.1,HGNC:HGNC:29564 chromosome 16 open reading frame 70 C16orf71 11.054999290779 10.9638672866938 11.1461312948641 1.01662406187564 0.0237862826015834 1 1 0.129719 0.0630892 0.0535217 0.0750718 GeneID:146562,Genbank:NM_139170.2,HGNC:HGNC:25081 chromosome 16 open reading frame 71 C16orf72 851.682951875248 915.30080267202 788.065101078477 0.860990287321822 -0.215931131959408 0.177115913893672 1 4.98101 4.44364 4.47478 3.69967 GeneID:29035,Genbank:XM_011522462.3,HGNC:HGNC:30103 chromosome 16 open reading frame 72 C16orf74 94.8999597631017 102.096513739693 87.7034057865109 0.859024491376085 -0.219228830714397 0.47236172683334 1 4.03833 5.35811 3.39389 4.81302 GeneID:404550,Genbank:NM_206967.2,HGNC:HGNC:23362 chromosome 16 open reading frame 74 C16orf86 16.5987461029268 14.7883859529828 18.4091062528707 1.24483539389622 0.315954985578638 0.706598717157855 1 0.0835782 0.0984365 0.104138 0.255349 GeneID:388284,Genbank:NM_001012984.2,HGNC:HGNC:33755 chromosome 16 open reading frame 86 C16orf87 269.987845667471 316.550597694004 223.425093640938 0.705811630963698 -0.502644890619272 0.0485196716942938 0.806708656465773 2.23321 1.85122 1.57491 1.21115 GeneID:388272,Genbank:NM_001348660.1,HGNC:HGNC:33754 chromosome 16 open reading frame 87 C16orf89 0.729234031512454 0.490071401957362 0.968396661067546 1.97603177251261 0.982606144127986 1 1 0 0.0168767 0 0.0332355 GeneID:146556,Genbank:XM_005255143.3,HGNC:HGNC:28687 chromosome 16 open reading frame 89 GO:0005829,GO:0016020,GO:0042803,GO:0070062 cytosol|membrane|protein homodimerization activity|extracellular exosome C16orf91 232.178079276943 230.31089060718 234.045267946705 1.01621450609513 0.0232049633460191 0.984088198700713 1 10.6038 14.4604 11.0115 14.4836 GeneID:283951,Genbank:NM_001272051.1,HGNC:HGNC:27558 chromosome 16 open reading frame 91 GO:0016021 integral component of membrane C16orf95 80.9553126501506 65.9567085095414 95.9539167907598 1.45480147446835 0.540822293105159 0.100826049517404 1 1.13629 1.9751 3.35992 2.98825 GeneID:100506581,Genbank:NM_001195125.1,HGNC:HGNC:40033 chromosome 16 open reading frame 95 C17orf100 68.5946751944314 71.2896590012795 65.8996913875833 0.924393415690213 -0.113421111136456 0.763883333922941 1 1.81805 1.78927 1.43701 1.99472 GeneID:388327,Genbank:NM_001105520.1,HGNC:HGNC:34494 chromosome 17 open reading frame 100 C17orf107 7.58888217900175 5.48683797090087 9.69092638710264 1.76621333425516 0.820659611210419 0.492954147326555 1 0.0338872 0.116155 0.124864 0.175402 GeneID:100130311,Genbank:NM_001145536.1,HGNC:HGNC:37238 chromosome 17 open reading frame 107 C17orf113 10.2689293774462 8.90752912949446 11.6303296253979 1.30567404903429 0.384794784683957 0.684805920140514 1 0.328618 0.126655 0.219336 0.333359 GeneID:110806298,Genbank:NM_001358661.1,HGNC:HGNC:53437 chromosome 17 open reading frame 113 C17orf49 714.641510026899 717.863930616415 711.419089437384 0.991022196680787 -0.0130107239713897 0.953532915763568 1 25.8863 22.7217 23.6753 24.1588 GeneID:124944,Genbank:NM_001142798.2,HGNC:HGNC:28737,MIM:617215 chromosome 17 open reading frame 49 GO:0003677,GO:0005654,GO:0005829,GO:0016569,GO:0016589,GO:0071339 DNA binding|nucleoplasm|cytosol|covalent chromatin modification|NURF complex|MLL1 complex C17orf51 718.61313011963 760.64422141076 676.582038828501 0.889485543679869 -0.168956936534717 0.292885320562337 1 3.92995 4.13239 3.99614 3.31318 GeneID:339263,Genbank:XM_005256621.4,HGNC:HGNC:27904 chromosome 17 open reading frame 51 C17orf53 320.823623030031 301.917116221038 339.730129839024 1.12524302726283 0.170236624874979 0.398108620086949 1 2.8751 3.3805 3.58794 3.38895 GeneID:78995,Genbank:NM_024032.4,HGNC:HGNC:28460 chromosome 17 open reading frame 53 C17orf58 287.554288955783 274.136933788631 300.971644122934 1.09788797869532 0.134730858691566 0.506987231986402 1 6.84698 6.45363 7.67796 6.2037 GeneID:284018,Genbank:NM_181655.3,HGNC:HGNC:27568 chromosome 17 open reading frame 58 C17orf67 36.7643608476729 39.1184512614723 34.4102704338736 0.879642964489349 -0.185010023275277 0.723825878187217 1 0.613665 0.501664 0.47488 0.441881 GeneID:339210,Genbank:NM_001085430.3,HGNC:HGNC:27900 chromosome 17 open reading frame 67 GO:0005576 extracellular region C17orf75 359.271672787859 340.525878770337 378.017466805381 1.11009908606779 0.150688455493051 0.424631820976966 1 2.299 2.29953 2.69581 2.4567 GeneID:64149,Genbank:NM_022344.3,HGNC:HGNC:30173 chromosome 17 open reading frame 75 C17orf78 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.013067 GeneID:284099,Genbank:XM_011524648.3,HGNC:HGNC:26831 chromosome 17 open reading frame 78 GO:0016021 integral component of membrane C17orf80 606.974764111447 617.35330094218 596.596227280715 0.966377318093567 -0.0493415014184404 0.780410068542353 1 4.26795 3.97206 4.31099 3.80883 GeneID:55028,Genbank:NM_001351264.1,HGNC:HGNC:29601 chromosome 17 open reading frame 80 GO:0016021,GO:0070062 integral component of membrane|extracellular exosome C17orf82 4.18981428607656 4.01662376502878 4.36300480712434 1.086236865178 0.119338732015856 1 1 0.109875 0.269597 0.295548 0.138707 GeneID:388407,Genbank:NM_203425.2,HGNC:HGNC:32699 chromosome 17 open reading frame 82 C17orf97 65.0103070908849 61.2000733140226 68.8205408677471 1.12451729452387 0.169305849227739 0.644967358330539 1 1.20167 0.804998 1.24586 0.949255 GeneID:400566,Genbank:NM_001013672.4,HGNC:HGNC:33800 chromosome 17 open reading frame 97 GO:0016598 protein arginylation C17orf99 0.971768182806039 0.490071401957362 1.45346496365472 2.96582285326082 1.56843242909583 0.837471602739444 1 0 0 0.0189037 0 GeneID:100141515,Genbank:XM_017023997.1,HGNC:HGNC:34490 chromosome 17 open reading frame 99 GO:0005576 extracellular region C18orf21 99.4345622322265 112.118455842049 86.7506686224045 0.773741200508666 -0.370076997739391 0.22197380919762 1 2.17989 2.11607 1.76726 1.55996 GeneID:83608,Genbank:XM_005258364.5,HGNC:HGNC:28802 chromosome 18 open reading frame 21 C18orf25 269.631243770349 280.450027084284 258.812460456413 0.922846979717465 -0.115836645179215 0.586721967727514 1 2.42666 2.33049 2.41345 1.92363 GeneID:147339,Genbank:XM_011525822.2,HGNC:HGNC:28172 chromosome 18 open reading frame 25 GO:0000209,GO:0042787,GO:0043161,GO:0061630 protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity C18orf32 10.7240256056459 11.7519049918688 9.69614621942302 0.82507016744365 -0.277411277446071 0.792845998245669 1 2.17168 2.71171 3.35428 3.2479 GeneID:497661,Genbank:NM_001199346.1,HGNC:HGNC:31690 chromosome 18 open reading frame 32 GO:0004871,GO:0043123 signal transducer activity|positive regulation of I-kappaB kinase/NF-kappaB signaling C18orf54 58.4644838073331 60.7001932569573 56.2287743577089 0.926336002254227 -0.11039250954354 0.865166271533821 1 0.405993 0.272834 0.407241 0.222985 GeneID:162681,Genbank:XM_005258201.1,HGNC:HGNC:13796,MIM:613258 chromosome 18 open reading frame 54 GO:0005576,GO:0008285 extracellular region|negative regulation of cell proliferation C18orf65 2.72503816560136 2.05633815719933 3.3937381740034 1.65037941941687 0.722797735734548 0.792472188633315 1 0.0261247 0.0485437 0.12466 0.0463795 GeneID:400658,Genbank:NM_001272093.2,HGNC:HGNC:51248 chromosome 18 open reading frame 65 C19orf12 754.149029305543 738.2744417101 770.023616900985 1.04300457038353 0.0607454796747541 0.715584143803881 1 4.3773 4.48526 4.49638 4.98017 GeneID:83636,Genbank:NM_001256047.1,HGNC:HGNC:25443,MIM:614297 chromosome 19 open reading frame 12 GO:0005739,GO:0005783,GO:0005829,GO:0006914,GO:0006915,GO:0006979,GO:0016021,GO:0031966,GO:0051560 mitochondrion|endoplasmic reticulum|cytosol|autophagy|apoptotic process|response to oxidative stress|integral component of membrane|mitochondrial membrane|mitochondrial calcium ion homeostasis C19orf18 3.96705177833356 3.57457863775636 4.35952491891075 1.21959127514035 0.286397734570853 0.943676605977403 1 0.0877607 0.0824166 0.0413688 0.270672 GeneID:147685,Genbank:NM_152474.4,HGNC:HGNC:28642 chromosome 19 open reading frame 18 GO:0016021,GO:0070062 integral component of membrane|extracellular exosome C19orf24 1043.69692587332 989.802481425502 1097.59137032114 1.10889939247313 0.149128479508422 0.46138584632899 1 57.612 60.9816 61.8831 72.1231 GeneID:55009,Genbank:NM_017914.3,HGNC:HGNC:26073 chromosome 19 open reading frame 24 GO:0005576,GO:0005737,GO:0016021 extracellular region|cytoplasm|integral component of membrane C19orf25 703.257978561412 671.857087763925 734.658869358898 1.09347491116599 0.128920119378559 0.445537929209116 1 12.3958 12.6903 13.6988 14.4268 GeneID:148223,Genbank:NM_152482.2,HGNC:HGNC:26711 chromosome 19 open reading frame 25 C19orf33 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.12892 0 GeneID:64073,Genbank:NM_001317801.1,HGNC:HGNC:16668 chromosome 19 open reading frame 33 GO:0005634,GO:0005829,GO:0005886 nucleus|cytosol|plasma membrane C19orf38 3.45971028251071 3.52655236307142 3.39286820195 0.962092109415047 -0.0557530725812868 1 1 0.0266513 0.117909 0.0493577 0.0463383 GeneID:255809,Genbank:XM_005259847.5,HGNC:HGNC:34073 chromosome 19 open reading frame 38 GO:0016021 integral component of membrane C19orf44 239.181471825686 240.909148005755 237.453795645616 0.985657031338401 -0.0208423603149137 0.917521564162963 1 1.48639 1.71576 1.5209 1.72654 GeneID:84167,Genbank:NM_032207.3,HGNC:HGNC:26141 chromosome 19 open reading frame 44 C19orf47 731.149326716061 742.16660396129 720.132049470831 0.970310501209769 -0.043481608542152 0.770757995655706 1 1.77463 2.13644 1.76565 1.93171 GeneID:126526,Genbank:XM_011526460.2,HGNC:HGNC:26723 chromosome 19 open reading frame 47 GO:0005654 nucleoplasm C19orf48 1909.02662752317 1992.54873305574 1825.50452199059 0.916165558064434 -0.126319767071417 0.423857382742557 1 30.9085 36.6137 30.4537 32.5143 GeneID:84798,Genbank:NM_001290150.1,HGNC:HGNC:29667 chromosome 19 open reading frame 48 C19orf53 2671.11065273987 2671.23739448175 2670.98391099799 0.999905106343494 -0.000136909103658738 0.981817692466398 1 96.9351 107.482 94.0863 113.578 GeneID:28974,Genbank:NM_014047.2,HGNC:HGNC:24991 chromosome 19 open reading frame 53 GO:0005634,GO:0005730 nucleus|nucleolus C19orf54 315.661269360911 298.380755202859 332.941783518964 1.11582861063747 0.158115448697592 0.427762488089718 1 2.1967 2.34608 3.04104 2.72567 GeneID:284325,Genbank:XM_011526774.3,HGNC:HGNC:24758 chromosome 19 open reading frame 54 C19orf57 122.530017744094 99.2041116026333 145.855923885554 1.47026087456724 0.556072161219935 0.044376560220404 0.785206567052859 0.829596 0.789785 1.0754 1.41587 GeneID:79173,Genbank:NM_024323.4,HGNC:HGNC:28153 chromosome 19 open reading frame 57 GO:0007275 multicellular organism development C19orf66 523.29274396438 350.337115464592 696.248372464167 1.98736685817845 0.990858211602145 0.327740685605183 1 3.96769 4.06697 12.8634 3.99307 GeneID:55337,Genbank:NM_018381.3,HGNC:HGNC:25649,MIM:616808 chromosome 19 open reading frame 66 GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0034340,GO:0034341,GO:0034342,GO:0045071,GO:0051607 RNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|response to type I interferon|response to interferon-gamma|response to type III interferon|negative regulation of viral genome replication|defense response to virus C19orf67 0.975139704544532 0.980142803914724 0.97013660517434 0.989791080748215 -0.0148040531050533 1 1 0 0.031429 0.0333128 0 GeneID:646457,Genbank:XM_011528184.2,HGNC:HGNC:34354 chromosome 19 open reading frame 67 C19orf70 994.311231121582 1009.77973904617 978.842723196997 0.969362609831731 -0.0448916588145138 0.823395888612029 1 10.0362 14.2993 11.8347 12.6055 GeneID:125988,Genbank:NM_205767.2,HGNC:HGNC:33702,MIM:616658 chromosome 19 open reading frame 70 GO:0005654,GO:0005739,GO:0005743,GO:0042407,GO:0044284,GO:0061617 nucleoplasm|mitochondrion|mitochondrial inner membrane|cristae formation|mitochondrial crista junction|MICOS complex C19orf71 23.4842556983404 19.3431073946539 27.625404002027 1.428178184528 0.514175986298399 0.402975352699455 1 0.0815995 0.136881 0.222333 0.34613 GeneID:100128569,Genbank:NM_001135580.1,HGNC:HGNC:34496 chromosome 19 open reading frame 71 C19orf73 10.0020554692585 8.36943145285216 11.6346794856649 1.39013976650708 0.47522994072555 0.617827979207884 1 1.22385 0.467543 1.62127 0.570824 GeneID:55150,Genbank:NM_018111.2,HGNC:HGNC:25534 chromosome 19 open reading frame 73 C19orf81 4.05921195431683 7.14915727551272 0.969266633120943 0.135577746546558 -2.88280769798833 0.0956915018209769 1 0.093434 0.317148 0.0853238 0.079704 GeneID:342918,Genbank:NM_001195076.1,HGNC:HGNC:40041 chromosome 19 open reading frame 81 C1D 265.156743649843 279.27777918163 251.035708118057 0.898874621724899 -0.153808197423744 0.466554112043708 1 8.0686 7.01535 7.44643 6.51772 GeneID:10438,Genbank:NM_173177.2,HGNC:HGNC:29911,MIM:606997 C1D nuclear receptor corepressor GO:0000176,GO:0000460,GO:0003677,GO:0003714,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006351,GO:0006364,GO:0006915,GO:0016922,GO:0017053,GO:0045892 nuclear exosome (RNase complex)|maturation of 5.8S rRNA|DNA binding|transcription corepressor activity|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|transcription, DNA-templated|rRNA processing|apoptotic process|ligand-dependent nuclear receptor binding|transcriptional repressor complex|negative regulation of transcription, DNA-templated hsa03018 RNA degradation C1GALT1 513.595478522107 538.145047269574 489.045909774639 0.908762260762126 -0.138025171292388 0.564920298765166 1 2.73114 2.38706 2.68209 1.96573 GeneID:56913,Genbank:XM_005249812.1,HGNC:HGNC:24337,MIM:610555 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 hsa00512 Mucin type O-glycan biosynthesis C1GALT1C1 1303.7146760096 1316.87388427807 1290.55546774112 0.980014474543719 -0.0291250372939773 0.85246867659198 1 27.4965 28.5028 28.0775 26.6237 GeneID:29071,Genbank:NM_001011551.2,HGNC:HGNC:24338,MIM:300611 C1GALT1 specific chaperone 1 hsa00512 Mucin type O-glycan biosynthesis C1GALT1C1L 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0337945 0 0 GeneID:728819,Genbank:NM_001101330.2,HGNC:HGNC:51617 C1GALT1 specific chaperone 1 like GO:0016021 integral component of membrane C1QBP 6399.19342446208 6998.64243517775 5799.74441374642 0.828695631683478 -0.271085777594059 0.0377950796599617 0.744558420459959 217.273 238.383 185.35 197.441 GeneID:708,Genbank:NM_001212.3,HGNC:HGNC:1243,MIM:601269 complement C1q binding protein hsa05168 Herpes simplex infection C1QL1 1196.37364559939 1013.99725956419 1378.75003163459 1.35971770991489 0.443307165609225 0.00307533556061981 0.207825208180957 40.8303 39.0652 55.0896 54.6991 GeneID:10882,Genbank:NM_006688.4,HGNC:HGNC:24182,MIM:611586 complement C1q like 1 C1QL2 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.0336581 0 GeneID:165257,Genbank:NM_182528.3,HGNC:HGNC:24181,MIM:614330 complement C1q like 2 GO:0005576,GO:0005581,GO:0042802,GO:0051259 extracellular region|collagen trimer|identical protein binding|protein oligomerization C1QL4 46.6564426945809 45.3354920077552 47.9773933814066 1.05827446128079 0.0817138359378152 0.858592007962471 1 1.2524 1.00837 1.2512 1.14488 GeneID:338761,Genbank:XM_011538270.2,HGNC:HGNC:31416,MIM:615229 complement C1q like 4 GO:0005581,GO:0005615,GO:0042802,GO:0045599,GO:0048147,GO:0070373 collagen trimer|extracellular space|identical protein binding|negative regulation of fat cell differentiation|negative regulation of fibroblast proliferation|negative regulation of ERK1 and ERK2 cascade C1QTNF1 2033.70448693764 1806.71765316624 2260.69132070904 1.25126984659015 0.323392952058366 0.0229742282123213 0.613948474678957 14.2806 15.5844 18.7065 19.6162 GeneID:114897,Genbank:NM_153372.2,HGNC:HGNC:14324,MIM:610365 C1q and TNF related 1 GO:0005518,GO:0005581,GO:0005615,GO:0005887,GO:0007204,GO:0010544,GO:0010628,GO:0010906,GO:0043410,GO:0051260,GO:0051897,GO:0070208,GO:0090331,GO:2000860 collagen binding|collagen trimer|extracellular space|integral component of plasma membrane|positive regulation of cytosolic calcium ion concentration|negative regulation of platelet activation|positive regulation of gene expression|regulation of glucose metabolic process|positive regulation of MAPK cascade|protein homooligomerization|positive regulation of protein kinase B signaling|protein heterotrimerization|negative regulation of platelet aggregation|positive regulation of aldosterone secretion C1QTNF12 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0 0 0 GeneID:388581,Genbank:NM_001014980.2,HGNC:HGNC:32308,MIM:616593 C1q and TNF related 12 GO:0005179,GO:0005576,GO:0005615,GO:0035774,GO:0045721,GO:0046324,GO:0046326,GO:0046628,GO:0050728,GO:0051897 hormone activity|extracellular region|extracellular space|positive regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of gluconeogenesis|regulation of glucose import|positive regulation of glucose import|positive regulation of insulin receptor signaling pathway|negative regulation of inflammatory response|positive regulation of protein kinase B signaling C1QTNF2 161.005577300183 157.723505188552 164.287649411813 1.04161804681815 0.0588263496122563 0.846660729078892 1 1.28743 1.48917 1.45779 1.44801 GeneID:114898,Genbank:XM_017009013.2,HGNC:HGNC:14325 C1q and TNF related 2 GO:0000187,GO:0005102,GO:0005581,GO:0005615,GO:0042802,GO:0045725,GO:0046321,GO:0046326,GO:0051260,GO:0070208 activation of MAPK activity|receptor binding|collagen trimer|extracellular space|identical protein binding|positive regulation of glycogen biosynthetic process|positive regulation of fatty acid oxidation|positive regulation of glucose import|protein homooligomerization|protein heterotrimerization C1QTNF3 12.3630933784936 15.5185887283649 9.20759802862226 0.593327021534671 -0.753100606803185 0.380510067733175 1 0.183972 0.120769 0.0774096 0.0926144 GeneID:114899,Genbank:NM_030945.3,HGNC:HGNC:14326,MIM:612045 C1q and TNF related 3 GO:0005581,GO:0005623,GO:0010629,GO:0016020,GO:0035356,GO:0042347,GO:0045444,GO:0045721,GO:0050715,GO:0050728,GO:0070062,GO:0070165,GO:0070206,GO:0071638,GO:1900165 collagen trimer|cell|negative regulation of gene expression|membrane|cellular triglyceride homeostasis|negative regulation of NF-kappaB import into nucleus|fat cell differentiation|negative regulation of gluconeogenesis|positive regulation of cytokine secretion|negative regulation of inflammatory response|extracellular exosome|positive regulation of adiponectin secretion|protein trimerization|negative regulation of monocyte chemotactic protein-1 production|negative regulation of interleukin-6 secretion C1QTNF4 3.93934049970099 2.54640955915669 5.33227144024528 2.09403527451852 1.06628574501195 0.54475621539136 1 0 0.0570547 0.0607139 0.0572198 GeneID:114900,Genbank:XM_017017165.1,HGNC:HGNC:14346,MIM:614911 C1q and TNF related 4 GO:0005125,GO:0005615 cytokine activity|extracellular space C1QTNF6 251.182307308533 238.73713998897 263.627474628096 1.10425832629257 0.143077710581112 0.499089633868577 1 1.07557 1.00517 1.14483 1.18974 GeneID:114904,Genbank:XM_024452152.1,HGNC:HGNC:14343,MIM:614910 C1q and TNF related 6 GO:0005581,GO:0005615,GO:0042802,GO:0070208 collagen trimer|extracellular space|identical protein binding|protein heterotrimerization C1QTNF9B 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0254455 GeneID:387911,Genbank:NM_001007537.2,HGNC:HGNC:34072,MIM:614148 C1q and TNF related 9B GO:0005581,GO:0070062 collagen trimer|extracellular exosome C1R 36.9538431240577 34.6597823691711 39.2479038789443 1.13237594687999 0.179353009985483 0.704001544143365 1 0.368493 0.256643 0.345273 0.537186 GeneID:715,Genbank:NM_001733.5,HGNC:HGNC:1246,MIM:613785 complement C1r GO:0004252,GO:0005509,GO:0005576,GO:0005615,GO:0006955,GO:0006956,GO:0006958,GO:0008236,GO:0030449,GO:0031638,GO:0045087,GO:0070062,GO:0072562 serine-type endopeptidase activity|calcium ion binding|extracellular region|extracellular space|immune response|complement activation|complement activation, classical pathway|serine-type peptidase activity|regulation of complement activation|zymogen activation|innate immune response|extracellular exosome|blood microparticle hsa04145,hsa04610,hsa05133,hsa05150,hsa05322 Phagosome|Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Systemic lupus erythematosus C1RL 163.228882891678 123.880169489025 202.57759629433 1.63527057744522 0.709529368715046 0.00407907561565333 0.249352958245434 0.994285 1.11032 1.89133 1.71171 GeneID:51279,Genbank:NM_001297640.1,HGNC:HGNC:21265,MIM:608974 complement C1r subcomponent like GO:0004252,GO:0005615,GO:0006958,GO:0045087,GO:0070062 serine-type endopeptidase activity|extracellular space|complement activation, classical pathway|innate immune response|extracellular exosome C1S 5.7017467091833 6.07296192222811 5.33053149613849 0.877748216504997 -0.18812093518778 0.941889117868029 1 0.0510601 0.0827499 0.0364668 0.0338614 GeneID:716,Genbank:NM_201442.3,HGNC:HGNC:1247,MIM:120580 complement C1s hsa04610,hsa05133,hsa05150,hsa05322 Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Systemic lupus erythematosus C1orf105 3.72669255717346 3.57457863775636 3.87880647659057 1.08510872739539 0.117839607292066 1 1 0 0 0.0285698 0 GeneID:92346,Genbank:XM_011510152.2,HGNC:HGNC:29591 chromosome 1 open reading frame 105 C1orf109 684.527199317528 785.089956578835 583.96444205622 0.743818510430251 -0.426977444042005 0.00845408322122956 0.35820263722543 8.62871 9.27222 6.57133 6.83524 GeneID:54955,Genbank:XM_011541641.1,HGNC:HGNC:26039,MIM:614799 chromosome 1 open reading frame 109 GO:0005634,GO:0005737 nucleus|cytoplasm C1orf112 546.379112389312 536.858146508189 555.900078270436 1.03546920520085 0.0502846485225512 0.763642437759846 1 3.56176 3.02584 3.83167 2.97873 GeneID:55732,Genbank:NM_001320051.1,HGNC:HGNC:25565 chromosome 1 open reading frame 112 C1orf115 87.0968470023873 83.0895902678332 91.1041037369415 1.0964562882459 0.132848298114665 0.688017741271678 1 1.02521 1.07363 1.11764 1.23525 GeneID:79762,Genbank:NM_024709.4,HGNC:HGNC:25873 chromosome 1 open reading frame 115 GO:0016021 integral component of membrane C1orf116 12.6334342687 11.2138073152264 14.0530612221736 1.25319267819877 0.325608245873963 0.733880691345313 1 0.0549103 0.080902 0.0838409 0.0905798 GeneID:79098,Genbank:XM_006711530.1,HGNC:HGNC:28667,MIM:611680 chromosome 1 open reading frame 116 GO:0005737,GO:0005829,GO:0005886,GO:0070062 cytoplasm|cytosol|plasma membrane|extracellular exosome C1orf122 1045.51361092365 960.01398711058 1131.01323473672 1.1781216210618 0.23648848063329 0.253823612634911 1 37.6488 38.3564 42.6883 51.9806 GeneID:127687,Genbank:NM_198446.2,HGNC:HGNC:24789 chromosome 1 open reading frame 122 GO:0000049,GO:0002949,GO:0003725,GO:0005737,GO:0005739,GO:0006450,GO:0016020,GO:0016779,GO:0051051 tRNA binding|tRNA threonylcarbamoyladenosine modification|double-stranded RNA binding|cytoplasm|mitochondrion|regulation of translational fidelity|membrane|nucleotidyltransferase activity|negative regulation of transport C1orf123 597.132185852187 630.191209942441 564.073161761933 0.895082560439794 -0.159907335366674 0.343721612146698 1 18.5686 17.5324 16.1037 16.6855 GeneID:54987,Genbank:NM_001304760.1,HGNC:HGNC:26059 chromosome 1 open reading frame 123 GO:0070062 extracellular exosome C1orf127 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0130348 0 0 GeneID:148345,Genbank:NM_001170754.1,HGNC:HGNC:26730 chromosome 1 open reading frame 127 C1orf131 191.569190948319 188.308828862902 194.829553033737 1.03462781968435 0.0491118892128303 0.841851441253287 1 3.89896 3.96528 4.17386 3.76812 GeneID:128061,Genbank:NM_001300830.1,HGNC:HGNC:25332 chromosome 1 open reading frame 131 GO:0003723,GO:0005694 RNA binding|chromosome C1orf158 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:93190,Genbank:NM_152290.3,HGNC:HGNC:28567 chromosome 1 open reading frame 158 C1orf159 400.401094175221 385.968248983425 414.833939367016 1.07478773308327 0.104051760590139 0.618231050797464 1 1.34881 1.53198 1.50884 1.60569 GeneID:54991,Genbank:XM_024447899.1,HGNC:HGNC:26062 chromosome 1 open reading frame 159 GO:0016021 integral component of membrane C1orf162 29.4331175783556 31.2390912105775 27.6271439461338 0.884377325828841 -0.17726605789879 0.75763303752121 1 0.139871 0.153491 0.141236 0.0766596 GeneID:128346,Genbank:XM_017000324.2,HGNC:HGNC:28344 chromosome 1 open reading frame 162 GO:0016021 integral component of membrane C1orf167 6.08759807895341 5.87104816838041 6.30414798952642 1.07376873919695 0.102683309208313 0.981369319782907 1 0.0463183 0.00576655 0.012272 0.00574753 GeneID:284498,Genbank:XM_024446507.1,HGNC:HGNC:25262 chromosome 1 open reading frame 167 C1orf174 582.690337349735 602.776637398153 562.604037301317 0.933354085735242 -0.099503595992545 0.558779627763715 1 5.18327 5.20506 4.79651 5.39966 GeneID:339448,Genbank:NM_207356.2,HGNC:HGNC:27915 chromosome 1 open reading frame 174 GO:0005634 nucleus C1orf189 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0655428 0 GeneID:388701,Genbank:NM_001010979.2,HGNC:HGNC:32305 chromosome 1 open reading frame 189 C1orf198 542.410612774298 554.634987147601 530.186238400996 0.955919209366252 -0.0650394025934352 0.715682408834 1 5.80837 5.48899 5.74507 5.38886 GeneID:84886,Genbank:NM_001136494.1,HGNC:HGNC:25900 chromosome 1 open reading frame 198 GO:0005829 cytosol C1orf21 446.001247409161 402.062136007155 489.940358811168 1.21856876073118 0.285187660964414 0.107775190075101 1 1.64857 1.5677 1.9347 1.94623 GeneID:81563,Genbank:NM_030806.3,HGNC:HGNC:15494 chromosome 1 open reading frame 21 C1orf216 1220.54479988962 1118.54311331281 1322.54648646643 1.18238311132185 0.241697567876279 0.102974769703708 1 12.8807 12.7539 15.5801 15.2001 GeneID:127703,Genbank:NM_152374.1,HGNC:HGNC:26800 chromosome 1 open reading frame 216 C1orf226 130.487406719447 112.176290771841 148.798522667053 1.32647034095376 0.407592418169479 0.130359771247952 1 1.00979 1.08183 1.63769 1.1841 GeneID:400793,Genbank:NM_001135240.2,HGNC:HGNC:34351 chromosome 1 open reading frame 226 C1orf229 4.36670294841444 0.980142803914724 7.75326309291415 7.91034027077212 2.98373975492524 0.0817208828149785 0.959088928094653 0 0.0541526 0.205337 0.219689 GeneID:388759,Genbank:NM_207401.2,HGNC:HGNC:33759 chromosome 1 open reading frame 229 C1orf35 516.475033397402 540.097558224005 492.852508570798 0.912524970843115 -0.132064056754067 0.42824657502442 1 12.9516 15.525 12.9528 13.2914 GeneID:79169,Genbank:NM_024319.3,HGNC:HGNC:19032 chromosome 1 open reading frame 35 GO:0003723,GO:0005576,GO:0034774,GO:0043312,GO:1904813 RNA binding|extracellular region|secretory granule lumen|neutrophil degranulation|ficolin-1-rich granule lumen C1orf43 6910.49660449341 6800.48313500016 7020.51007398667 1.03235460402131 0.0459386079613412 0.737889919488879 1 86.9648 91.9502 91.0663 95.4531 GeneID:25912,Genbank:NM_001297718.1,HGNC:HGNC:29876,MIM:617428 chromosome 1 open reading frame 43 GO:0016021,GO:0016491 integral component of membrane|oxidoreductase activity C1orf50 151.044179155545 159.135884464632 142.952473846458 0.898304454255443 -0.154723607378436 0.538062187256645 1 4.84488 5.94773 4.60615 5.6273 GeneID:79078,Genbank:NM_024097.3,HGNC:HGNC:28795 chromosome 1 open reading frame 50 GO:0042802 identical protein binding C1orf52 633.0553763571 677.793745515497 588.317007198704 0.867988250247512 -0.204252581508367 0.229385570282698 1 2.65706 2.56651 2.25011 2.18764 GeneID:148423,Genbank:NM_198077.3,HGNC:HGNC:24871 chromosome 1 open reading frame 52 GO:0003723,GO:0005634 RNA binding|nucleus C1orf53 48.1188496528261 51.658393958516 44.5793053471362 0.862963439841653 -0.212628655154536 0.615082721509221 1 5.2565 5.01952 3.72532 4.50071 GeneID:388722,Genbank:NM_001024594.2,HGNC:HGNC:30003 chromosome 1 open reading frame 53 C1orf54 4.19188084973496 4.50669516698614 3.87706653248377 0.860290387707 -0.217104376711089 0.95019451384955 1 0.101753 0.190855 0.144884 0 GeneID:79630,Genbank:XM_024449802.1,HGNC:HGNC:26258 chromosome 1 open reading frame 54 GO:0005576 extracellular region C1orf56 102.499875417819 94.9953827388647 110.004368096773 1.15799699864537 0.211631514082712 0.494164784683118 1 2.6281 2.98084 3.0368 3.26645 GeneID:54964,Genbank:NM_017860.4,HGNC:HGNC:26045 chromosome 1 open reading frame 56 GO:0005576,GO:0042127 extracellular region|regulation of cell proliferation C1orf61 3.28464742990104 2.69048838321152 3.87880647659057 1.44167374993851 0.527744720335303 0.81233580623888 1 0.00897239 0 0 0.00785356 GeneID:10485,Genbank:NM_001320453.1,HGNC:HGNC:30780 chromosome 1 open reading frame 61 GO:0005634,GO:0045944 nucleus|positive regulation of transcription from RNA polymerase II promoter C1orf74 182.793185476134 184.350040027666 181.236330924602 0.983109799690866 -0.0245755403528197 0.921044554262246 1 1.54 1.71188 1.47664 1.71356 GeneID:148304,Genbank:NM_152485.3,HGNC:HGNC:26319 chromosome 1 open reading frame 74 C1orf94 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0111756 0.0117285 0 GeneID:84970,Genbank:NM_032884.4,HGNC:HGNC:28250 chromosome 1 open reading frame 94 C2 6.82259681541436 7.83133377620985 5.81385985461886 0.742384378032807 -0.429761742681209 0.776104510279942 1 0.0214484 0.0291352 0.0101028 0.0470619 GeneID:717,Genbank:NM_001282457.1,HGNC:HGNC:1248,MIM:613927 complement C2 hsa04610,hsa05133,hsa05150,hsa05322 Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Systemic lupus erythematosus C20orf141 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0747713 GeneID:128653,Genbank:NM_001256538.1,HGNC:HGNC:16134 chromosome 20 open reading frame 141 GO:0016021 integral component of membrane C20orf144 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:128864,Genbank:NM_080825.3,HGNC:HGNC:16137 chromosome 20 open reading frame 144 C20orf194 310.746242763911 291.423703026086 330.068782501737 1.1326078801222 0.179648472527459 0.366167193712753 1 1.38676 1.40219 1.77882 1.37707 GeneID:25943,Genbank:NM_001009984.2,HGNC:HGNC:17721,MIM:614146 chromosome 20 open reading frame 194 C20orf196 72.2228232472088 72.7216555875746 71.723990906843 0.986281051047715 -0.0199292787347813 0.94585586775363 1 0.332388 0.508224 0.403238 0.4211 GeneID:149840,Genbank:XM_011529178.2,HGNC:HGNC:26318 chromosome 20 open reading frame 196 C20orf202 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0239596 0.0247044 0 GeneID:400831,Genbank:NM_001009612.2,HGNC:HGNC:37254 chromosome 20 open reading frame 202 C20orf203 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0074809 0 GeneID:284805,Genbank:NM_182584.3,HGNC:HGNC:26592 chromosome 20 open reading frame 203 GO:0005737 cytoplasm C20orf204 5.46214909360151 6.56303332418548 4.36126486301754 0.664519688928871 -0.58961614941265 0.681538361423504 1 0.0799469 0.0524507 0.0556945 0.0869844 GeneID:284739,Genbank:NM_001348090.1,HGNC:HGNC:27655 chromosome 20 open reading frame 204 C20orf27 904.121593162189 907.837112785638 900.40607353874 0.991814567677128 -0.0118576792141371 0.912323133367445 1 21.3933 23.7514 22.5581 23.5164 GeneID:54976,Genbank:NM_001258429.1,HGNC:HGNC:15873 chromosome 20 open reading frame 27 C20orf96 113.501944106359 105.853388821081 121.150499391637 1.14451224227136 0.194732894758799 0.492778028672238 1 1.57956 1.19626 1.46414 1.66208 GeneID:140680,Genbank:NM_153269.2,HGNC:HGNC:16227 chromosome 20 open reading frame 96 GO:0016491 oxidoreductase activity C21orf2 247.595685587277 253.843109555387 241.348261619168 0.950777281455055 -0.0728206639710354 0.71658633770311 1 2.49643 2.8543 2.77759 2.7628 GeneID:755,Genbank:XM_017028470.1,HGNC:HGNC:1260,MIM:603191 chromosome 21 open reading frame 2 GO:0001750,GO:0005737,GO:0005739,GO:0005886,GO:0007010,GO:0008360,GO:0030030,GO:0032391,GO:0036064,GO:0042769 photoreceptor outer segment|cytoplasm|mitochondrion|plasma membrane|cytoskeleton organization|regulation of cell shape|cell projection organization|photoreceptor connecting cilium|ciliary basal body|DNA damage response, detection of DNA damage C21orf58 636.791210883081 616.969090744701 656.613331021461 1.06425644472547 0.0898458265493341 0.585592962382486 1 3.25061 3.14752 3.05795 3.70551 GeneID:54058,Genbank:XM_006724018.4,HGNC:HGNC:1300 chromosome 21 open reading frame 58 C21orf91 77.3464525877338 80.5235633984606 74.169341777007 0.92108866829439 -0.118588051327265 0.878387576307914 1 0.844005 0.520904 0.877122 0.399953 GeneID:54149,Genbank:NM_001100421.1,HGNC:HGNC:16459 chromosome 21 open reading frame 91 GO:0021895,GO:0060999 cerebral cortex neuron differentiation|positive regulation of dendritic spine development C22orf15 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0141409 0 0 0 GeneID:150248,Genbank:XM_017028617.1,HGNC:HGNC:15558 chromosome 22 open reading frame 15 C22orf23 36.712515159028 33.6894482203643 39.7355820976917 1.17946669348157 0.238134679427389 0.642098629972873 1 0.429641 0.503697 0.453654 0.501462 GeneID:84645,Genbank:NM_001207062.1,HGNC:HGNC:18589 chromosome 22 open reading frame 23 C22orf24 2.91236801270632 0.980142803914724 4.84459322149792 4.94274222301939 2.30531166810645 0.287368225417295 1 0 0.0566357 0 0.0545709 GeneID:25775,Genbank:NM_015372.2,HGNC:HGNC:23051 chromosome 22 open reading frame 24 GO:0016021 integral component of membrane C22orf31 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0 0 0 0 GeneID:25770,Genbank:XM_011530096.3,HGNC:HGNC:26931 chromosome 22 open reading frame 31 C22orf39 481.997804103574 466.281106973785 497.714501233364 1.0674129699648 0.0941184465027793 0.675538486455523 1 6.36322 8.72157 8.47388 7.76992 GeneID:128977,Genbank:NM_001166242.1,HGNC:HGNC:27012 chromosome 22 open reading frame 39 C22orf46 415.044948921777 368.690271400224 461.399626443331 1.25145592990836 0.323607487332968 0.07712285779257 0.94157495521624 1.54508 1.59545 2.18741 1.80296 GeneID:79640,Genbank:XM_017028939.1,HGNC:HGNC:26294 chromosome 22 open reading frame 46 GO:0005576 extracellular region C2CD2 368.336577984466 328.101605932879 408.571550036053 1.24525922046122 0.316446093415184 0.0944905024828352 0.994506734213175 1.65619 1.68248 2.43573 1.82984 GeneID:25966,Genbank:XM_011529522.2,HGNC:HGNC:1266,MIM:617581 C2 calcium dependent domain containing 2 GO:0005634,GO:0005829,GO:0016021 nucleus|cytosol|integral component of membrane C2CD2L 504.371752678549 540.596421280216 468.147084076881 0.865982580809982 -0.207590089371625 0.233426910527083 1 2.98656 2.88472 2.61488 2.61039 GeneID:9854,Genbank:XM_017018626.2,HGNC:HGNC:29000,MIM:617582 C2CD2 like GO:0005548,GO:0005789,GO:0005886,GO:0008526,GO:0016021,GO:0032541,GO:0035091,GO:0035774,GO:0043559 phospholipid transporter activity|endoplasmic reticulum membrane|plasma membrane|phosphatidylinositol transporter activity|integral component of membrane|cortical endoplasmic reticulum|phosphatidylinositol binding|positive regulation of insulin secretion involved in cellular response to glucose stimulus|insulin binding C2CD3 764.229018226572 745.239268540272 783.218767912872 1.05096282627054 0.071711640466963 0.664479139213787 1 2.73803 2.17435 2.92731 2.26508 GeneID:26005,Genbank:XM_017017510.1,HGNC:HGNC:24564,MIM:615944 C2 calcium dependent domain containing 3 GO:0001701,GO:0001947,GO:0005813,GO:0005814,GO:0005829,GO:0007420,GO:0008589,GO:0016485,GO:0021915,GO:0021997,GO:0030162,GO:0034451,GO:0036064,GO:0042733,GO:0061511,GO:0071539,GO:0097711,GO:1905515 in utero embryonic development|heart looping|centrosome|centriole|cytosol|brain development|regulation of smoothened signaling pathway|protein processing|neural tube development|neural plate axis specification|regulation of proteolysis|centriolar satellite|ciliary basal body|embryonic digit morphogenesis|centriole elongation|protein localization to centrosome|ciliary basal body-plasma membrane docking|non-motile cilium assembly C2CD4C 179.147096081247 167.380854403645 190.91333775885 1.14059244373586 0.189783380200667 0.643416842288366 1 2.62468 3.36263 2.93921 4.06159 GeneID:126567,Genbank:XM_011527694.1,HGNC:HGNC:29417,MIM:610336 C2 calcium dependent domain containing 4C GO:0005509,GO:0005544,GO:0005886 calcium ion binding|calcium-dependent phospholipid binding|plasma membrane C2CD4D 3.55913435361909 4.20872886376855 2.90953984346962 0.691310829860488 -0.532593568253355 0.84410906285695 1 0.129421 0.0271076 0.117723 0.0275859 GeneID:100191040,Genbank:XM_016999989.2,HGNC:HGNC:37210 C2 calcium dependent domain containing 4D GO:0005509,GO:0005544,GO:0005886 calcium ion binding|calcium-dependent phospholipid binding|plasma membrane C2CD5 291.311459387467 291.317841821608 291.305076953326 0.999956182332665 -6.32169163871403e-05 1 1 1.80741 1.83646 2.15448 1.27872 GeneID:9847,Genbank:NM_014802.2,HGNC:HGNC:29062 C2 calcium dependent domain containing 5 GO:0005509,GO:0005544,GO:0005815,GO:0005829,GO:0005886,GO:0005938,GO:0006906,GO:0010828,GO:0030659,GO:0031340,GO:0032587,GO:0032869,GO:0038028,GO:0065002,GO:0072659,GO:0090314,GO:2001275 calcium ion binding|calcium-dependent phospholipid binding|microtubule organizing center|cytosol|plasma membrane|cell cortex|vesicle fusion|positive regulation of glucose transport|cytoplasmic vesicle membrane|positive regulation of vesicle fusion|ruffle membrane|cellular response to insulin stimulus|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|intracellular protein transmembrane transport|protein localization to plasma membrane|positive regulation of protein targeting to membrane|positive regulation of glucose import in response to insulin stimulus C2orf15 23.7456185617046 27.6164862981362 19.874750825273 0.719669787485396 -0.474593001158872 0.422775325617537 1 0.523587 0.726691 0.617206 0.23464 GeneID:150590,Genbank:NM_001317992.1,HGNC:HGNC:28436 chromosome 2 open reading frame 15 GO:0003723 RNA binding C2orf27A 102.860941824806 122.842191755318 82.8796918942945 0.674684249035363 -0.567715613358497 0.0550447165943173 0.855410907895938 1.58527 1.5033 1.32726 1.0054 GeneID:29798,Genbank:NM_001354871.1,HGNC:HGNC:25077 chromosome 2 open reading frame 27A C2orf42 183.63802544749 183.610028597176 183.666022297805 1.00030495992543 0.000439897099999989 1 1 1.95 2.03591 1.84877 1.97737 GeneID:54980,Genbank:NM_017880.2,HGNC:HGNC:26056 chromosome 2 open reading frame 42 GO:0005634,GO:0031965 nucleus|nuclear membrane C2orf48 8.35234268488838 8.46548400222204 8.23920136755471 0.973269970788683 -0.0390880519629456 1 1 0.223151 0.0339842 0.122766 0.114759 GeneID:348738,Genbank:NM_182626.3,HGNC:HGNC:26322 chromosome 2 open reading frame 48 C2orf49 359.290453456406 391.944141355429 326.636765557384 0.833375808164405 -0.262960873833954 0.166695096100085 1 1.46987 1.50587 1.28865 1.19613 GeneID:79074,Genbank:NM_024093.2,HGNC:HGNC:28772 chromosome 2 open reading frame 49 GO:0005654,GO:0006388,GO:0048598,GO:0072669 nucleoplasm|tRNA splicing, via endonucleolytic cleavage and ligation|embryonic morphogenesis|tRNA-splicing ligase complex C2orf50 1.96678789737625 0.538097676642304 3.39547811811019 6.31015197704952 2.65767475225938 0.516835147792981 1 0 0 0.0407446 0 GeneID:130813,Genbank:NM_182500.2,HGNC:HGNC:26324 chromosome 2 open reading frame 50 C2orf66 2.21302018995993 1.51824048055703 2.90779989936283 1.91524329419539 0.937527669974993 0.766544435698746 1 0.0226759 0.0441096 0.0655552 0.0613744 GeneID:401027,Genbank:NM_213608.2,HGNC:HGNC:33809 chromosome 2 open reading frame 66 GO:0005576 extracellular region C2orf68 543.809844254298 511.375450607261 576.244237901335 1.12685158667089 0.172297516154828 0.320024305372525 1 3.63402 3.76832 4.45071 4.15884 GeneID:388969,Genbank:NM_001013649.3,HGNC:HGNC:34353 chromosome 2 open reading frame 68 C2orf69 218.699343600859 233.326737257223 204.071949944495 0.874618795699879 -0.193273742384507 0.625368754486978 1 3.48134 2.87175 3.55541 2.08416 GeneID:205327,Genbank:NM_153689.5,HGNC:HGNC:26799 chromosome 2 open reading frame 69 GO:0005576 extracellular region C2orf70 1.75783809613882 2.54640955915669 0.969266633120943 0.380640509942925 -1.39349898523626 0.672311225248235 1 0.00850775 0.00765382 0.00800642 0.0074911 GeneID:339778,Genbank:NM_001322426.1,HGNC:HGNC:27938 chromosome 2 open reading frame 70 GO:0005634 nucleus C2orf71 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0.00476772 0.00446604 GeneID:388939,Genbank:NM_001029883.2,HGNC:HGNC:34383,MIM:613425 chromosome 2 open reading frame 71 GO:0001750,GO:0001917,GO:0005929,GO:0007601,GO:0035845,GO:0050896,GO:1903546 photoreceptor outer segment|photoreceptor inner segment|cilium|visual perception|photoreceptor cell outer segment organization|response to stimulus|protein localization to photoreceptor outer segment C2orf72 19.6879298185444 21.4474718265382 17.9283878105506 0.835920800155417 -0.258561835159821 0.708495682781412 1 0.264804 0.336778 0.219657 0.299907 GeneID:257407,Genbank:NM_001144994.1,HGNC:HGNC:27418 chromosome 2 open reading frame 72 C2orf73 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0 0.0130428 0.0121425 GeneID:129852,Genbank:XM_011532513.3,HGNC:HGNC:26861 chromosome 2 open reading frame 73 C2orf74 210.972873229998 218.903961192359 203.041785267636 0.927538196027507 -0.108521401741702 0.643927287067299 1 4.91552 5.17024 4.26196 4.6966 GeneID:339804,Genbank:NM_001143960.2,HGNC:HGNC:34439 chromosome 2 open reading frame 74 GO:0016021 integral component of membrane C2orf76 115.043157541089 118.643271546657 111.44304353552 0.939311956613524 -0.0903237213361157 0.789368235180574 1 0.504711 0.485158 0.385197 0.579049 GeneID:130355,Genbank:XM_017003354.2,HGNC:HGNC:27017 chromosome 2 open reading frame 76 C2orf78 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0104361 0 0 GeneID:388960,Genbank:NM_001080474.1,HGNC:HGNC:34349 chromosome 2 open reading frame 78 C2orf81 98.0456662723861 87.5482591601344 108.543073384638 1.2398084716465 0.310117267105926 0.310007089075581 1 1.67923 1.27306 1.58098 2.12826 GeneID:388963,Genbank:NM_001316765.1,HGNC:HGNC:34350 chromosome 2 open reading frame 81 C2orf88 0.99578132014851 0.538097676642304 1.45346496365472 2.70111733751434 1.43355631240266 0.835241087836065 1 0.00730399 0 0.0070477 0.013113 GeneID:84281,Genbank:XM_011511986.2,HGNC:HGNC:28191,MIM:615117 chromosome 2 open reading frame 88 GO:0005886,GO:0034237 plasma membrane|protein kinase A regulatory subunit binding C2orf92 16.6801384745914 15.9126075809524 17.4476693682304 1.09646827394371 0.132864068567583 0.891609602484217 1 0.0898343 0.0732909 0.110994 0.103156 GeneID:728537,Genbank:XM_024453105.1,HGNC:HGNC:49272 chromosome 2 open reading frame 92 GO:0005654 nucleoplasm C3 181.936174240282 237.882475699749 125.989872780815 0.529630744804577 -0.916941222572921 0.000118339036907978 0.0256124056097052 1.13515 1.26832 0.634783 0.692671 GeneID:718,Genbank:NM_000064.3,HGNC:HGNC:1318,MIM:120700 complement C3 hsa04145,hsa04610,hsa05133,hsa05134,hsa05140,hsa05142,hsa05150,hsa05152,hsa05167,hsa05168,hsa05203,hsa05322 Phagosome|Complement and coagulation cascades|Pertussis|Legionellosis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Staphylococcus aureus infection|Tuberculosis|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Viral carcinogenesis|Systemic lupus erythematosus C3AR1 17.478389516798 19.9292313459811 15.0275476876149 0.754045523719875 -0.407276469454 0.566493208316809 1 0.194322 0.261463 0.171913 0.123398 GeneID:719,Genbank:NM_001326475.1,HGNC:HGNC:1319,MIM:605246 complement C3a receptor 1 hsa04080,hsa04610,hsa05150 Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Staphylococcus aureus infection C3orf14 0.995346334121811 0.538097676642304 1.45259499160132 2.69950058261805 1.43269252815597 0.83528100889094 1 0.0117545 0 0 0.0315096 GeneID:57415,Genbank:NM_001291941.1,HGNC:HGNC:25024 chromosome 3 open reading frame 14 C3orf18 241.546606560266 211.726394952377 271.366818168155 1.28168629248702 0.358043188901773 0.0986609407596615 1 1.5013 1.57546 1.83366 2.16927 GeneID:51161,Genbank:NM_001171741.2,HGNC:HGNC:24837 chromosome 3 open reading frame 18 GO:0016021 integral component of membrane C3orf20 15.8986366746021 14.8364122276678 16.9608611215364 1.14319155205912 0.193067160378202 0.832362688451209 1 0.0445023 0.0820066 0.0902849 0.0843083 GeneID:84077,Genbank:XM_011534153.3,HGNC:HGNC:25320 chromosome 3 open reading frame 20 GO:0005737,GO:0016021 cytoplasm|integral component of membrane C3orf33 71.8468360940651 71.4915727551272 72.202099433003 1.00993860745391 0.0142675965277877 1 1 0.541931 0.7461 0.673216 0.834982 GeneID:285315,Genbank:NM_001308229.1,HGNC:HGNC:26434 chromosome 3 open reading frame 33 GO:0005615,GO:0016021,GO:0051090,GO:0070373 extracellular space|integral component of membrane|regulation of DNA binding transcription factor activity|negative regulation of ERK1 and ERK2 cascade C3orf35 7.61540977222412 10.8678147373239 4.36300480712434 0.401461095222781 -1.31666790900949 0.235964258640182 1 0.0407184 0.0307894 0.0117168 0.0109218 GeneID:339883,Genbank:XM_017006291.1,HGNC:HGNC:24082,MIM:611429 chromosome 3 open reading frame 35 GO:0016021 integral component of membrane C3orf38 598.900448563006 599.230467724866 598.570429401146 0.998898523424174 -0.00158997061213304 1 1 9.2442 9.1048 10.2755 8.12799 GeneID:285237,Genbank:NM_173824.3,HGNC:HGNC:28384 chromosome 3 open reading frame 38 GO:0005634,GO:0006915,GO:0043065 nucleus|apoptotic process|positive regulation of apoptotic process C3orf49 1.05218221594214 2.10436443188427 0 0 -Inf 0.405312649089613 1 0 0 0 0 GeneID:132200,Genbank:NM_001355236.1,HGNC:HGNC:25190 chromosome 3 open reading frame 49 C3orf58 172.242825887556 187.453147572826 157.032504202287 0.837716017231876 -0.255466836603475 0.331461947830889 1 2.66667 2.05167 2.20412 1.71945 GeneID:205428,Genbank:NM_173552.3,HGNC:HGNC:28490,MIM:612200 chromosome 3 open reading frame 58 GO:0000139,GO:0005615,GO:0014066,GO:0030126,GO:0060038 Golgi membrane|extracellular space|regulation of phosphatidylinositol 3-kinase signaling|COPI vesicle coat|cardiac muscle cell proliferation C3orf62 190.224601787226 190.94148231632 189.507721258132 0.992491097058664 -0.0108739339787931 0.991887169052737 1 1.92476 1.66015 2.04005 1.53483 GeneID:375341,Genbank:NM_198562.2,HGNC:HGNC:24771 chromosome 3 open reading frame 62 C3orf67 56.2250555054111 53.8107846650852 58.6393263457369 1.08973185785534 0.123973185522603 0.769358641609453 1 0.165917 0.196113 0.213091 0.193497 GeneID:200844,Genbank:XM_005264929.2,HGNC:HGNC:24763 chromosome 3 open reading frame 67 C3orf70 68.3064238774511 80.3892932295138 56.2235545253885 0.699391078919783 -0.515828701025413 0.148412905985888 1 0.551557 0.457223 0.410656 0.301698 GeneID:285382,Genbank:NM_001025266.2,HGNC:HGNC:33731 chromosome 3 open reading frame 70 C3orf80 19.1464735263584 24.7240841610769 13.5688628916398 0.548811547608353 -0.865617257141151 0.190997694020918 1 0.585754 0.538683 0.315389 0.338648 GeneID:401097,Genbank:NM_001168214.1,HGNC:HGNC:40048 chromosome 3 open reading frame 80 GO:0016021 integral component of membrane C4A 8.03439759982889 7.83133377620985 8.23746142344792 1.05185932037168 0.072941766062069 0.993157035130852 1 0.0786078 0.0208345 0.0366779 0.068602 GeneID:720,Genbank:NM_007293.2,HGNC:HGNC:1323,MIM:120810 complement C4A (Rodgers blood group) hsa04610,hsa05133,hsa05150,hsa05322 Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Systemic lupus erythematosus C4B 3.27020550527226 4.60274771635603 1.93766329418849 0.420979687264399 -1.24817747154797 0.520190377932444 1 0.0315051 0.0278353 0.00734733 0.02062 GeneID:721,Genbank:NM_001002029.3,HGNC:HGNC:1324,MIM:120820 complement C4B (Chido blood group) hsa04610,hsa05133,hsa05150,hsa05322 Complement and coagulation cascades|Pertussis|Staphylococcus aureus infection|Systemic lupus erythematosus C4orf19 68.8124330826779 68.7912757168078 68.8335904485481 1.00061511770642 0.000887154440370492 1 1 0.359839 0.340245 0.463419 0.268488 GeneID:55286,Genbank:XM_011513713.2,HGNC:HGNC:25618 chromosome 4 open reading frame 19 GO:0005654,GO:0030054 nucleoplasm|cell junction C4orf3 940.194700850965 885.513325357953 994.876076343976 1.1235020951738 0.16800281494419 0.270619706295842 1 14.2318 13.8919 15.3104 16.6027 GeneID:401152,Genbank:NM_001170330.1,HGNC:HGNC:19225 chromosome 4 open reading frame 3 GO:0016021 integral component of membrane C4orf33 128.853249897225 121.025984971543 136.680514822907 1.12934850193572 0.175490751328364 0.507618604275181 1 0.953001 0.770598 1.09606 0.904685 GeneID:132321,Genbank:NM_173487.2,HGNC:HGNC:27025 chromosome 4 open reading frame 33 C4orf36 11.3830460348591 8.22535262879733 14.5407394409209 1.7677952663103 0.82195120154953 0.350309394298492 1 0.0460587 0.127648 0.262462 0.0612325 GeneID:132989,Genbank:NM_144645.3,HGNC:HGNC:28386 chromosome 4 open reading frame 36 C4orf46 559.778371207649 639.751489607309 479.805252807988 0.749986925552141 -0.415062649419513 0.0158373430157811 0.525157113334885 10.6773 9.79204 8.41269 7.23177 GeneID:201725,Genbank:NM_001008393.3,HGNC:HGNC:27320,MIM:616210 chromosome 4 open reading frame 46 GO:0005737 cytoplasm C4orf47 5.29089274875704 6.21704074628294 4.36474475123113 0.702061467723328 -0.510330746270014 0.763185757375231 1 0.0109836 0.0214068 0.021229 0.00985579 GeneID:441054,Genbank:XM_017008237.1,HGNC:HGNC:34346 chromosome 4 open reading frame 47 GO:0005737,GO:0005813 cytoplasm|centrosome C4orf48 452.517916069113 410.778577038764 494.257255099462 1.20322062231795 0.266901199073726 0.333445852122532 1 3.99591 4.42211 4.33838 5.31692 GeneID:401115,Genbank:XM_011513471.2,HGNC:HGNC:34437,MIM:614690 chromosome 4 open reading frame 48 GO:0005576 extracellular region C4orf54 8.85545228157821 6.56303332418548 11.1478712389709 1.69858519503319 0.764333580518832 0.474712780611494 1 0.0148689 0.0307104 0.0457027 0.0328887 GeneID:285556,Genbank:XM_006714430.3,HGNC:HGNC:27741,MIM:617881 chromosome 4 open reading frame 54 C5 87.6224129096242 76.372669464485 98.8721563547633 1.29460128928374 0.372507845756086 0.229173765864751 1 0.387492 0.339838 0.534775 0.46657 GeneID:727,Genbank:NM_001317163.1,HGNC:HGNC:1331,MIM:120900 complement C5 hsa04610,hsa05020,hsa05133,hsa05150,hsa05168,hsa05322 Complement and coagulation cascades|Prion diseases|Pertussis|Staphylococcus aureus infection|Herpes simplex infection|Systemic lupus erythematosus C5AR1 4.72410545495367 4.60274771635603 4.84546319355132 1.05273273534693 0.0741392157268066 1 1 0.0791555 0.0717894 0.0742807 0.104093 GeneID:728,Genbank:NM_001736.3,HGNC:HGNC:1338,MIM:113995 complement C5a receptor 1 GO:0000187,GO:0001856,GO:0004878,GO:0004930,GO:0005886,GO:0005887,GO:0006915,GO:0006935,GO:0006954,GO:0006955,GO:0006968,GO:0007165,GO:0007186,GO:0007200,GO:0007202,GO:0007204,GO:0007606,GO:0009986,GO:0010575,GO:0010759,GO:0016323,GO:0021534,GO:0030449,GO:0030593,GO:0030667,GO:0031100,GO:0032494,GO:0032496,GO:0042789,GO:0043312,GO:0043524,GO:0045177,GO:0045766,GO:0050679,GO:0050830,GO:0050900,GO:0060326,GO:0070374,GO:0090023 activation of MAPK activity|complement component C5a binding|complement component C5a receptor activity|G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|apoptotic process|chemotaxis|inflammatory response|immune response|cellular defense response|signal transduction|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|sensory perception of chemical stimulus|cell surface|positive regulation of vascular endothelial growth factor production|positive regulation of macrophage chemotaxis|basolateral plasma membrane|cell proliferation in hindbrain|regulation of complement activation|neutrophil chemotaxis|secretory granule membrane|animal organ regeneration|response to peptidoglycan|response to lipopolysaccharide|mRNA transcription from RNA polymerase II promoter|neutrophil degranulation|negative regulation of neuron apoptotic process|apical part of cell|positive regulation of angiogenesis|positive regulation of epithelial cell proliferation|defense response to Gram-positive bacterium|leukocyte migration|cell chemotaxis|positive regulation of ERK1 and ERK2 cascade|positive regulation of neutrophil chemotaxis hsa04080,hsa04610,hsa05150 Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Staphylococcus aureus infection C5orf15 1999.46792617866 1856.70086816247 2142.23498419484 1.15378573949553 0.206375337270302 0.13812482516865 1 37.5825 37.3384 48.4521 38.5696 GeneID:56951,Genbank:NM_020199.2,HGNC:HGNC:20656 chromosome 5 open reading frame 15 GO:0016021 integral component of membrane C5orf22 749.315417838373 788.086185918663 710.544649758083 0.90160779677899 -0.149428103416994 0.489698533016324 1 7.77109 6.80683 7.64674 5.77166 GeneID:55322,Genbank:NM_018356.2,HGNC:HGNC:25639 chromosome 5 open reading frame 22 C5orf24 1324.27910795512 1473.29762904757 1175.26058686267 0.7977075125156 -0.32606823013602 0.0472209723140876 0.797733134720091 13.4377 11.558 10.5701 9.39692 GeneID:134553,Genbank:XM_017009050.1,HGNC:HGNC:26746 chromosome 5 open reading frame 24 C5orf30 300.630240534676 352.633584995217 248.626896074136 0.705057336151089 -0.504187510826486 0.0114096762034551 0.432003248403162 4.91103 5.26045 3.78848 3.21913 GeneID:90355,Genbank:NM_033211.3,HGNC:HGNC:25052,MIM:616608 chromosome 5 open reading frame 30 GO:0005737,GO:0010764,GO:0015031,GO:0035869,GO:0060271,GO:1900016 cytoplasm|negative regulation of fibroblast migration|protein transport|ciliary transition zone|cilium assembly|negative regulation of cytokine production involved in inflammatory response C5orf34 145.898358266975 161.902808086997 129.893908446954 0.802295586974357 -0.317794233149611 0.227269573197157 1 1.83582 1.52477 1.5373 1.23973 GeneID:375444,Genbank:XM_017009446.1,HGNC:HGNC:24738 chromosome 5 open reading frame 34 C5orf46 212.937605678501 219.451867524109 206.423343832892 0.940631520532465 -0.0882984172163033 0.709865291062433 1 1.02589 1.08429 0.95319 1.15518 GeneID:389336,Genbank:XM_017009459.1,HGNC:HGNC:33768 chromosome 5 open reading frame 46 GO:0070062 extracellular exosome C5orf49 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0164936 0 0 GeneID:134121,Genbank:NM_001089584.2,HGNC:HGNC:27028 chromosome 5 open reading frame 49 C5orf51 99.3482769190765 113.867019040922 84.8295347972306 0.744987754239389 -0.424711383464649 0.35980653485137 1 3.63844 3.35579 3.48559 2.25282 GeneID:285636,Genbank:XM_005248289.4,HGNC:HGNC:27750 chromosome 5 open reading frame 51 GO:0005654,GO:0005829 nucleoplasm|cytosol C5orf56 51.0590003834653 42.9909962024462 59.1270045644843 1.37533459997189 0.459782649179189 0.259773481647613 1 1.85612 2.17186 3.51924 2.99491 GeneID:441108,Genbank:NM_001207001.2,HGNC:HGNC:33838 chromosome 5 open reading frame 56 C5orf58 1.45640149936651 0.490071401957362 2.42273159677566 4.94362982026534 2.30557071806793 0.554025919298353 1 0 0.0205833 0.0206527 0 GeneID:133874,Genbank:XM_017009029.1,HGNC:HGNC:37272 chromosome 5 open reading frame 58 C5orf64 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:285668,Genbank:XM_017009382.1,HGNC:HGNC:26744 chromosome 5 open reading frame 64 GO:0005576 extracellular region C5orf66 92.5482685303809 103.691189459404 81.4053476013582 0.785074874979899 -0.349097840104957 0.271689811468703 1 0.454008 0.511507 0.35405 0.149078 GeneID:100996485,Genbank:NM_001277348.1,HGNC:HGNC:48332 chromosome 5 open reading frame 66 C5orf67 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:101928448,Genbank:XM_017008942.1,HGNC:HGNC:51252 chromosome 5 open reading frame 67 C6 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0.00766328 0.00772211 0 GeneID:729,Genbank:NM_001115131.2,HGNC:HGNC:1339,MIM:217050 complement C6 hsa04610,hsa05020,hsa05322 Complement and coagulation cascades|Prion diseases|Systemic lupus erythematosus C6orf106 4448.58258485756 3754.1354976172 5143.02967209792 1.36996378403557 0.454137755023106 0.000658814164494978 0.0753683404182255 30.7115 29.6348 44.6187 39.4716 GeneID:64771,Genbank:NM_022758.5,HGNC:HGNC:21215,MIM:612217 chromosome 6 open reading frame 106 GO:0000407,GO:0005776,GO:0016236,GO:0043130 phagophore assembly site|autophagosome|macroautophagy|ubiquitin binding C6orf118 15.4729187097151 21.7356294746478 9.21020794478245 0.423737805961641 -1.2387562429376 0.0960086396516672 1 0.236818 0.137813 0.129994 0.0661006 GeneID:168090,Genbank:XM_011535511.3,HGNC:HGNC:21233 chromosome 6 open reading frame 118 C6orf120 835.717592331626 840.734531336202 830.700653327051 0.988065343297838 -0.0173216407955227 0.938718269092263 1 9.73615 8.9746 10.4361 8.53646 GeneID:387263,Genbank:NM_001029863.2,HGNC:HGNC:21247,MIM:616987 chromosome 6 open reading frame 120 GO:0005576,GO:0006915,GO:0035578,GO:0043312,GO:0070062 extracellular region|apoptotic process|azurophil granule lumen|neutrophil degranulation|extracellular exosome C6orf136 460.802612058619 451.031058583314 470.574165533924 1.04332984742114 0.0611953361971509 0.762657026703762 1 7.88232 8.51193 9.01872 8.82312 GeneID:221545,Genbank:NM_001161376.1,HGNC:HGNC:21301 chromosome 6 open reading frame 136 C6orf141 545.792787026279 572.555906611067 519.029667441491 0.906513515009572 -0.141599565936197 0.41477258317686 1 5.75562 5.3495 5.03066 4.72936 GeneID:135398,Genbank:NM_001145652.1,HGNC:HGNC:21351 chromosome 6 open reading frame 141 C6orf15 2.21595672567172 2.00831188251439 2.42360156882906 1.2067854549537 0.271169213303733 1 1 0.0496766 0.133991 0.138926 0.0867769 GeneID:29113,Genbank:NM_014070.2,HGNC:HGNC:13927,MIM:611401 chromosome 6 open reading frame 15 GO:0005578 proteinaceous extracellular matrix C6orf163 1.76033964582391 3.03648096111406 0.484198330533773 0.15946035451384 -2.64873031325362 0.397094287453316 1 0.0476173 0.0690611 0 0.021256 GeneID:206412,Genbank:NM_001010868.2,HGNC:HGNC:21403 chromosome 6 open reading frame 163 C6orf201 33.0096544132953 39.3683912900049 26.6509175365856 0.676962320869635 -0.562852557995947 0.255445615474276 1 0 0 0 0 GeneID:404220,Genbank:XM_017010861.1,HGNC:HGNC:21620 chromosome 6 open reading frame 201 C6orf203 177.346130026138 174.894604566421 179.797655485855 1.02803431776291 0.0398884252710773 0.879699770821447 1 3.19156 2.99962 3.22119 2.82182 GeneID:51250,Genbank:NM_001142470.2,HGNC:HGNC:17971 chromosome 6 open reading frame 203 GO:0005739 mitochondrion C6orf223 2.696783534467 1.51824048055703 3.87532658837698 2.55251169890764 1.35191757341154 0.558069520044957 1 0 0.012058 0.0126495 0.035604 GeneID:221416,Genbank:XM_017010425.1,HGNC:HGNC:28692 chromosome 6 open reading frame 223 C6orf226 184.767732307894 168.437432446713 201.098032169074 1.19390345274167 0.255686175059545 0.283229355310545 1 22.9792 23.4486 24.7468 31.1047 GeneID:441150,Genbank:NM_001008739.1,HGNC:HGNC:34431 chromosome 6 open reading frame 226 C6orf47 774.193899313647 697.868072686388 850.519725940906 1.21873998715387 0.285390366109188 0.0738961376641793 0.937070895351936 11.8609 11.9418 14.9847 14.8556 GeneID:57827,Genbank:NM_021184.3,HGNC:HGNC:19076 chromosome 6 open reading frame 47 GO:0005829 cytosol C6orf48 3423.09404534954 3642.15537994752 3204.03271075157 0.879707858811268 -0.184903594568488 0.297121237935811 1 173.803 187.522 149.073 175.62 GeneID:50854,Genbank:NM_001287484.1,HGNC:HGNC:19078,MIM:605447 chromosome 6 open reading frame 48 C6orf52 17.3374189596978 12.3860552178809 22.2887827015147 1.79950616313561 0.847601043362919 0.218017300549196 1 0.0535139 0.0746878 0.0764311 0.0948486 GeneID:347744,Genbank:NM_001354357.1,HGNC:HGNC:20881 chromosome 6 open reading frame 52 C6orf58 1.51236740913344 2.05633815719933 0.968396661067546 0.470932593298016 -1.08640751970762 0.811664485952849 1 0.0422897 0.0810096 0 0.0378261 GeneID:352999,Genbank:NM_001010905.2,HGNC:HGNC:20960 chromosome 6 open reading frame 58 GO:0005615,GO:0007275,GO:0070062 extracellular space|multicellular organism development|extracellular exosome C6orf62 3229.49148315045 3226.72196091429 3232.2610053866 1.00171661659709 0.00247443103415282 0.973034073764558 1 26.5913 25.8574 29.1035 23.2171 GeneID:81688,Genbank:XM_011514928.3,HGNC:HGNC:20998 chromosome 6 open reading frame 62 GO:0005622 intracellular C6orf89 4197.6713062153 3970.03443781548 4425.30817461511 1.11467752835166 0.156626404732379 0.245394738680615 1 16.1254 17.1615 19.9274 17.404 GeneID:221477,Genbank:XM_017010434.2,HGNC:HGNC:21114,MIM:616642 chromosome 6 open reading frame 89 GO:0000139,GO:0005730,GO:0005737,GO:0005886,GO:0016021,GO:0030496,GO:0042060,GO:0045787,GO:0050673,GO:1901727 Golgi membrane|nucleolus|cytoplasm|plasma membrane|integral component of membrane|midbody|wound healing|positive regulation of cell cycle|epithelial cell proliferation|positive regulation of histone deacetylase activity C6orf99 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:100130967,Genbank:XM_011535374.2,HGNC:HGNC:21179 chromosome 6 open reading frame 99 C7 4.79451328934939 4.25675513845349 5.33227144024528 1.25266106853929 0.324996118664291 0.858639855136458 1 0.0496448 0.00673428 0.04087 0.025374 GeneID:730,Genbank:NM_000587.3,HGNC:HGNC:1346,MIM:217070 complement C7 hsa04610,hsa05020,hsa05322 Complement and coagulation cascades|Prion diseases|Systemic lupus erythematosus C7orf25 365.087287012906 347.329043467947 382.845530557865 1.10225602424519 0.140459361848114 0.452766590243258 1 3.46962 3.23348 3.68017 3.76452 GeneID:79020,Genbank:XM_017012597.2,HGNC:HGNC:21703 chromosome 7 open reading frame 25 C7orf26 855.087711811357 883.410994927779 826.764428694936 0.935877449388692 -0.0956084697097011 0.515342906197319 1 13.7808 15.5512 14.3996 13.7812 GeneID:79034,Genbank:NM_024067.3,HGNC:HGNC:21702 chromosome 7 open reading frame 26 C7orf31 121.700672161527 120.295782196161 123.105562126894 1.0233572605742 0.0333098870972761 0.910367194110682 1 1.04849 0.887155 1.00792 0.914444 GeneID:136895,Genbank:NM_138811.3,HGNC:HGNC:21722,MIM:616071 chromosome 7 open reading frame 31 GO:0005737,GO:0005813 cytoplasm|centrosome C7orf43 628.108987770906 656.760926852617 599.457048689194 0.912747735408013 -0.131711910651669 0.418439757671933 1 11.7048 11.5876 10.7033 10.6219 GeneID:55262,Genbank:NM_001303470.1,HGNC:HGNC:25604 chromosome 7 open reading frame 43 GO:0005815,GO:0005886,GO:0043231 microtubule organizing center|plasma membrane|intracellular membrane-bounded organelle C7orf50 2627.53048974973 2483.1480626812 2771.91291681826 1.11628982519281 0.158711646417719 0.258839449562453 1 13.2768 14.5628 15.4956 16.6875 GeneID:84310,Genbank:XM_011515580.3,HGNC:HGNC:22421 chromosome 7 open reading frame 50 GO:0003723 RNA binding C7orf57 58.1266097738013 75.0563427377757 41.196876809827 0.548879352591912 -0.865439024974637 0.0228254677298154 0.613376998591817 1.22794 1.12694 0.650104 0.669891 GeneID:136288,Genbank:NM_001100159.2,HGNC:HGNC:22247 chromosome 7 open reading frame 57 C7orf61 10.2052645865275 10.2336645113117 10.1768646617432 0.994449705723132 -0.00802968626035347 1 1 0.400471 0.400021 0.415716 0.475585 GeneID:402573,Genbank:NM_001004323.2,HGNC:HGNC:22135 chromosome 7 open reading frame 61 GO:0005634 nucleus C7orf65 4.28586683544644 4.20872886376855 4.36300480712434 1.03665618488373 0.0519374924070242 1 1 0.0965755 0.0289842 0.0906202 0.042332 GeneID:401335,Genbank:NM_001123065.1,HGNC:HGNC:34432 chromosome 7 open reading frame 65 C7orf69 1.04924568023034 1.61429302992691 0.484198330533773 0.299944509179783 -1.73723247328634 0.787670862996782 1 0 0 0 0.0448654 GeneID:80099,Genbank:NM_001302627.1,HGNC:HGNC:21911 chromosome 7 open reading frame 69 GO:0005576 extracellular region C8G 4.18143966496787 2.54640955915669 5.81646977077905 2.28418470621251 1.19167931618347 0.472340765737004 1 0 0.0703162 0.0758928 0.0710864 GeneID:733,Genbank:NM_000606.2,HGNC:HGNC:1354,MIM:120930 complement C8 gamma chain GO:0001848,GO:0005576,GO:0005579,GO:0006957,GO:0006958,GO:0019835,GO:0019841,GO:0030449,GO:0032403,GO:0070062,GO:0072562 complement binding|extracellular region|membrane attack complex|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|retinol binding|regulation of complement activation|protein complex binding|extracellular exosome|blood microparticle hsa04610,hsa05020,hsa05146,hsa05322 Complement and coagulation cascades|Prion diseases|Amoebiasis|Systemic lupus erythematosus C8orf33 2183.26713227097 2201.30222262849 2165.23204191346 0.983614162406124 -0.0238355873974626 0.867012618183248 1 9.58751 9.42692 9.24742 9.67315 GeneID:65265,Genbank:NM_023080.2,HGNC:HGNC:26104 chromosome 8 open reading frame 33 GO:0003723,GO:0003887,GO:0003964,GO:0004190,GO:0004523,GO:0005198,GO:0005886,GO:0008270,GO:0016032,GO:0019028 RNA binding|DNA-directed DNA polymerase activity|RNA-directed DNA polymerase activity|aspartic-type endopeptidase activity|RNA-DNA hybrid ribonuclease activity|structural molecule activity|plasma membrane|zinc ion binding|viral process|viral capsid C8orf34 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.00892448 0 GeneID:116328,Genbank:NM_052958.3,HGNC:HGNC:30905 chromosome 8 open reading frame 34 C8orf37 91.130367094693 108.10183207702 74.1589021123662 0.686009669656014 -0.543699182823883 0.0822845568551987 0.961246872788376 0.979131 0.872813 0.766324 0.512421 GeneID:157657,Genbank:NM_177965.3,HGNC:HGNC:27232,MIM:614477 chromosome 8 open reading frame 37 GO:0005737,GO:0005829,GO:0005886,GO:0030054,GO:0097546 cytoplasm|cytosol|plasma membrane|cell junction|ciliary base C8orf44 22.0944555256044 18.0169720128366 26.1719390383723 1.45262694639951 0.538664247580366 0.380262489420219 1 0.432422 0.474573 0.910638 0.545648 GeneID:56260,Genbank:NM_019607.2,HGNC:HGNC:25646 chromosome 8 open reading frame 44 GO:0005654 nucleoplasm C8orf46 164.825664448606 150.804670631356 178.846658265855 1.1859490658817 0.246042050374798 0.317924422033971 1 1.6433 1.70703 2.17792 1.71202 GeneID:254778,Genbank:NM_152765.3,HGNC:HGNC:28498 chromosome 8 open reading frame 46 C8orf48 19.9886048097384 23.0137385817801 16.9634710376966 0.737101926200139 -0.440063966399981 0.501844596935837 1 0.512723 0.611092 0.465964 0.366346 GeneID:157773,Genbank:NM_001007090.2,HGNC:HGNC:26345 chromosome 8 open reading frame 48 C8orf58 598.250362337541 618.834340804015 577.666383871067 0.933474996104029 -0.099316715692273 0.533870739776209 1 10.8976 11.6019 10.8121 10.7605 GeneID:541565,Genbank:NM_001013842.2,HGNC:HGNC:32233 chromosome 8 open reading frame 58 C8orf59 666.375807149327 712.973025251949 619.778589046705 0.869287570631005 -0.20209457827045 0.23671804116842 1 5.92464 5.46579 4.97811 5.8283 GeneID:401466,Genbank:NM_001293320.1,HGNC:HGNC:32235 chromosome 8 open reading frame 59 C8orf76 20.8209610536493 25.1661292883494 16.4757928189492 0.65468124359421 -0.611135448114957 0.33734070406121 1 7.89094 9.19053 6.86766 8.10113 GeneID:84933,Genbank:NM_032847.2,HGNC:HGNC:25924 chromosome 8 open reading frame 76 C8orf82 630.750288425156 613.568016896323 647.932559953989 1.0560077157077 0.0786203757688741 0.648432057681545 1 26.0288 24.5902 27.8837 28.5156 GeneID:414919,Genbank:NM_001001795.1,HGNC:HGNC:33826 chromosome 8 open reading frame 82 C8orf88 132.680021284737 128.223168521741 137.136874047732 1.06951712103792 0.0969595776303985 0.710125427552953 1 3.74891 3.08454 3.45694 4.14524 GeneID:100127983,Genbank:XM_017012939.2,HGNC:HGNC:44672 chromosome 8 open reading frame 88 GO:0005737,GO:0008190,GO:0045947 cytoplasm|eukaryotic initiation factor 4E binding|negative regulation of translational initiation C9orf116 49.7841784525763 46.7576799389423 52.8106769662103 1.12945460585667 0.175626288241831 0.726108022256301 1 3.08562 2.8434 2.43307 3.89207 GeneID:138162,Genbank:NM_144654.2,HGNC:HGNC:28435,MIM:614502 chromosome 9 open reading frame 116 C9orf129 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0297935 0 GeneID:445577,Genbank:NM_001098808.1,HGNC:HGNC:31116 chromosome 9 open reading frame 129 GO:0005634,GO:0035357,GO:0045444 nucleus|peroxisome proliferator activated receptor signaling pathway|fat cell differentiation C9orf131 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0087927 0 0 GeneID:138724,Genbank:NM_001040412.2,HGNC:HGNC:31418 chromosome 9 open reading frame 131 C9orf135 99.5511351245305 107.515708125693 91.5865621233684 0.851843546584821 -0.231339611963028 0.453875494669348 1 0.471703 0.629922 0.639665 0.386172 GeneID:138255,Genbank:XM_011518230.2,HGNC:HGNC:31422 chromosome 9 open reading frame 135 GO:0005737,GO:0005886,GO:0016021 cytoplasm|plasma membrane|integral component of membrane C9orf139 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0256212 0 GeneID:401563,Genbank:NM_207511.2,HGNC:HGNC:31426 chromosome 9 open reading frame 139 C9orf147 9.85831617095011 13.4142242964806 6.30240804541962 0.469830226938515 -1.0897885615043 0.253466614865824 1 0.0624243 0 0.0297465 0 GeneID:100133204,Genbank:NM_001350649.1,HGNC:HGNC:31438 chromosome 9 open reading frame 147 GO:0016021 integral component of membrane C9orf152 2.51402180070554 3.57457863775636 1.45346496365472 0.40661155088394 -1.29827689552794 0.586956146241499 1 0.0499952 0.0617627 0.0157842 0.0296344 GeneID:401546,Genbank:NM_001012993.2,HGNC:HGNC:31455 chromosome 9 open reading frame 152 C9orf16 568.953844816804 560.256095287448 577.65159434616 1.03104919197673 0.0441131661957023 0.785422354865007 1 33.204 28.2055 30.3506 33.2432 GeneID:79095,Genbank:XM_011519004.1,HGNC:HGNC:17823 chromosome 9 open reading frame 16 C9orf163 8.19556188031156 10.0895856872569 6.30153807336622 0.624558655696343 -0.679091025362473 0.518091920584086 1 0.161838 0.298847 0.198675 0.116154 GeneID:158055,Genbank:NM_152571.2,HGNC:HGNC:26718 chromosome 9 open reading frame 163 C9orf170 0.999152841887003 1.02816907859967 0.97013660517434 0.943557460895085 -0.0838177169406569 1 1 0.0105903 0.0101727 0.0204031 0 GeneID:401535,Genbank:NM_001001709.2,HGNC:HGNC:33817 chromosome 9 open reading frame 170 C9orf24 5.37129387569833 2.98845468642911 7.75413306496754 2.59469655008653 1.37556582517897 0.330861577885629 1 0.00493972 0.0187538 0.0189498 0.0176335 GeneID:84688,Genbank:XM_024447705.1,HGNC:HGNC:19919 chromosome 9 open reading frame 24 GO:0002177,GO:0005634,GO:0007283,GO:0030154,GO:0043014,GO:0043623,GO:0048471 manchette|nucleus|spermatogenesis|cell differentiation|alpha-tubulin binding|cellular protein complex assembly|perinuclear region of cytoplasm C9orf3 1251.71848636517 1182.34743111579 1321.08954161456 1.11734462041149 0.160074222059631 0.279798660979159 1 1.8098 1.85538 2.10816 1.97619 GeneID:84909,Genbank:XM_011519121.3,HGNC:HGNC:1361 chromosome 9 open reading frame 3 GO:0002003,GO:0004177,GO:0005730,GO:0005737,GO:0005829,GO:0006508,GO:0008237,GO:0008270,GO:0042277,GO:0043171,GO:0070006 angiotensin maturation|aminopeptidase activity|nucleolus|cytoplasm|cytosol|proteolysis|metallopeptidase activity|zinc ion binding|peptide binding|peptide catabolic process|metalloaminopeptidase activity C9orf40 432.976958046118 417.19651453804 448.757401554196 1.07564992974858 0.105208629204805 0.555167286025185 1 10.7125 10.2951 11.4843 11.5054 GeneID:55071,Genbank:NM_017998.2,HGNC:HGNC:23433 chromosome 9 open reading frame 40 C9orf43 14.7226906306575 11.511773618444 17.9336076428709 1.55784922786684 0.639555612902522 0.434965426546642 1 0.0604504 0.113208 0.244618 0.161218 GeneID:257169,Genbank:NM_001278629.1,HGNC:HGNC:23570 chromosome 9 open reading frame 43 C9orf47 2.99528359552752 3.084507235799 2.90605995525603 0.942147232312541 -0.0859755629376226 1 1 0.0308716 0.0288172 0.00989067 0.0456928 GeneID:286223,Genbank:NM_001001938.3,HGNC:HGNC:23669 chromosome 9 open reading frame 47 GO:0005576 extracellular region C9orf50 1.96841947500795 1.02816907859967 2.90866987141623 2.8289801083862 1.50028203264315 0.612213169729345 1 0.0196746 0 0.0543494 0.0169725 GeneID:375759,Genbank:XM_011518662.2,HGNC:HGNC:23677 chromosome 9 open reading frame 50 C9orf64 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0278098 GeneID:84267,Genbank:NM_001317997.1,HGNC:HGNC:28144,MIM:611342 chromosome 9 open reading frame 64 GO:0006400 tRNA modification C9orf72 133.799509691192 149.843128136803 117.755891245581 0.78586113831041 -0.347653684145853 0.402693289050632 1 1.71006 1.11881 1.02643 1.11728 GeneID:203228,Genbank:NM_001256054.2,HGNC:HGNC:28337,MIM:614260 chromosome 9 open reading frame 72 GO:0000932,GO:0001933,GO:0005085,GO:0005615,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005776,GO:0006897,GO:0006914,GO:0010494,GO:0010506,GO:0016239,GO:0017137,GO:0030425,GO:0031965,GO:0032045,GO:0034063,GO:0043204,GO:0044295,GO:0044304,GO:0048675,GO:0110053,GO:1902774,GO:1903432,GO:2000785 P-body|negative regulation of protein phosphorylation|guanyl-nucleotide exchange factor activity|extracellular space|nucleus|cytoplasm|lysosome|endosome|autophagosome|endocytosis|autophagy|cytoplasmic stress granule|regulation of autophagy|positive regulation of macroautophagy|Rab GTPase binding|dendrite|nuclear membrane|guanyl-nucleotide exchange factor complex|stress granule assembly|perikaryon|axonal growth cone|main axon|axon extension|regulation of actin filament organization|late endosome to lysosome transport|regulation of TORC1 signaling|regulation of autophagosome assembly C9orf78 1242.85380606365 1102.12081701969 1383.58679510761 1.25538577417406 0.328130765742394 0.0259223481614992 0.641688296993154 18.6 17.7677 22.6241 23.0042 GeneID:51759,Genbank:NM_016520.2,HGNC:HGNC:24932 chromosome 9 open reading frame 78 GO:0005654,GO:0005829 nucleoplasm|cytosol C9orf84 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:158401,Genbank:XM_017014340.1,HGNC:HGNC:26535 chromosome 9 open reading frame 84 C9orf85 96.3340673597885 103.499084360664 89.1690503589132 0.861544340316918 -0.215003046656326 0.497244152858849 1 1.15821 1.36005 1.2822 1.30787 GeneID:138241,Genbank:XM_011518226.3,HGNC:HGNC:28784 chromosome 9 open reading frame 85 C9orf92 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.119787 GeneID:100129385,Genbank:NM_001271829.1,HGNC:HGNC:19054 chromosome 9 open reading frame 92 CA1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0268404 0 0 GeneID:759,Genbank:NM_001291968.1,HGNC:HGNC:1368,MIM:114800 carbonic anhydrase 1 GO:0004064,GO:0004089,GO:0005829,GO:0006730,GO:0008270,GO:0015701,GO:0016836,GO:0035722,GO:0070062 arylesterase activity|carbonate dehydratase activity|cytosol|one-carbon metabolic process|zinc ion binding|bicarbonate transport|hydro-lyase activity|interleukin-12-mediated signaling pathway|extracellular exosome hsa00910 Nitrogen metabolism CA10 10.4718118751635 10.2816907859967 10.6619329643304 1.03698245612011 0.0523914865497778 1 1 0.0981208 0.0604215 0.07235 0.086792 GeneID:56934,Genbank:NM_001082534.1,HGNC:HGNC:1369,MIM:604642 carbonic anhydrase 10 GO:0007420 brain development CA11 325.894234465206 279.63358041464 372.154888515772 1.3308662284549 0.412365566558865 0.0615257553743037 0.886147929923425 4.38281 4.76465 5.45717 6.69885 GeneID:770,Genbank:NM_001217.4,HGNC:HGNC:1370,MIM:604644 carbonic anhydrase 11 GO:0005576,GO:0016323 extracellular region|basolateral plasma membrane CA12 23.9960698472265 25.7042269649917 22.2879127294613 0.867091344930028 -0.205744110741413 0.756544459133252 1 0.214551 0.179168 0.157062 0.224167 GeneID:771,Genbank:NM_001293642.1,HGNC:HGNC:1371,MIM:603263 carbonic anhydrase 12 GO:0004089,GO:0005886,GO:0006730,GO:0008270,GO:0015701,GO:0016021,GO:0055064 carbonate dehydratase activity|plasma membrane|one-carbon metabolic process|zinc ion binding|bicarbonate transport|integral component of membrane|chloride ion homeostasis hsa00910 Nitrogen metabolism CA13 300.270130861851 296.170529566497 304.369732157204 1.02768405959468 0.0393968056671564 0.848625699262427 1 3.79116 3.75207 4.46331 3.52404 GeneID:377677,Genbank:NM_198584.2,HGNC:HGNC:14914,MIM:611436 carbonic anhydrase 13 GO:0004089,GO:0005829,GO:0006730,GO:0008270,GO:0015701,GO:0043209,GO:0043231 carbonate dehydratase activity|cytosol|one-carbon metabolic process|zinc ion binding|bicarbonate transport|myelin sheath|intracellular membrane-bounded organelle hsa00910 Nitrogen metabolism CA14 54.8847093582363 58.8937951282906 50.875623588182 0.863853712897219 -0.211141071325452 0.636603016445778 1 0.516201 0.383443 0.359243 0.574833 GeneID:23632,Genbank:XM_011509379.3,HGNC:HGNC:1372,MIM:604832 carbonic anhydrase 14 GO:0004089,GO:0005886,GO:0015701,GO:0016021,GO:0046872 carbonate dehydratase activity|plasma membrane|bicarbonate transport|integral component of membrane|metal ion binding hsa00910 Nitrogen metabolism CA2 93.2283976567374 101.644659957312 84.8121353561626 0.834398338208631 -0.261191810304558 0.402483502754808 1 2.65834 2.76214 2.37521 2.05504 GeneID:760,Genbank:NM_000067.2,HGNC:HGNC:1373,MIM:611492 carbonic anhydrase 2 GO:0001822,GO:0002009,GO:0004064,GO:0004089,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0006730,GO:0008270,GO:0009268,GO:0010043,GO:0015670,GO:0015701,GO:0016323,GO:0030424,GO:0032230,GO:0032849,GO:0038166,GO:0042475,GO:0043209,GO:0043627,GO:0044070,GO:0045177,GO:0045672,GO:0045780,GO:0046903,GO:0048545,GO:0051453,GO:0070062,GO:0071498,GO:2001150,GO:2001225 kidney development|morphogenesis of an epithelium|arylesterase activity|carbonate dehydratase activity|cytoplasm|cytosol|plasma membrane|microvillus|one-carbon metabolic process|zinc ion binding|response to pH|response to zinc ion|carbon dioxide transport|bicarbonate transport|basolateral plasma membrane|axon|positive regulation of synaptic transmission, GABAergic|positive regulation of cellular pH reduction|angiotensin-activated signaling pathway|odontogenesis of dentin-containing tooth|myelin sheath|response to estrogen|regulation of anion transport|apical part of cell|positive regulation of osteoclast differentiation|positive regulation of bone resorption|secretion|response to steroid hormone|regulation of intracellular pH|extracellular exosome|cellular response to fluid shear stress|positive regulation of dipeptide transmembrane transport|regulation of chloride transport hsa00910,hsa04964,hsa04966,hsa04971,hsa04972,hsa04976 Nitrogen metabolism|Proximal tubule bicarbonate reclamation|Collecting duct acid secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion CA3 7.59475525042534 6.46698077481559 8.72252972603509 1.3487792881654 0.431654287559231 0.766880096415072 1 0.0535566 0.251261 0.176762 0.211114 GeneID:761,Genbank:NM_005181.3,HGNC:HGNC:1374,MIM:114750 carbonic anhydrase 3 GO:0004089,GO:0005829,GO:0006730,GO:0006979,GO:0008270,GO:0015701,GO:0016151,GO:0016791,GO:0045471 carbonate dehydratase activity|cytosol|one-carbon metabolic process|response to oxidative stress|zinc ion binding|bicarbonate transport|nickel cation binding|phosphatase activity|response to ethanol hsa00910 Nitrogen metabolism CA4 2.53466341630952 3.13253351048394 1.93679332213509 0.618283352964316 -0.693659932761692 0.833296029032968 1 0.0548463 0.0246615 0 0.0481128 GeneID:762,Genbank:NM_000717.4,HGNC:HGNC:1375,MIM:114760 carbonic anhydrase 4 GO:0004089,GO:0005791,GO:0005793,GO:0005794,GO:0005802,GO:0005886,GO:0006730,GO:0008270,GO:0009986,GO:0015701,GO:0016020,GO:0016324,GO:0030658,GO:0030667,GO:0031362,GO:0031526,GO:0048471,GO:0070062 carbonate dehydratase activity|rough endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|trans-Golgi network|plasma membrane|one-carbon metabolic process|zinc ion binding|cell surface|bicarbonate transport|membrane|apical plasma membrane|transport vesicle membrane|secretory granule membrane|anchored component of external side of plasma membrane|brush border membrane|perinuclear region of cytoplasm|extracellular exosome hsa00910,hsa04964 Nitrogen metabolism|Proximal tubule bicarbonate reclamation CA5B 77.3240917374671 80.0050830320342 74.6431004429 0.932979475979204 -0.100082750389861 0.779212531453767 1 0.381182 0.437692 0.456283 0.30313 GeneID:11238,Genbank:XM_005274442.5,HGNC:HGNC:1378,MIM:300230 carbonic anhydrase 5B GO:0004089,GO:0005739,GO:0005759,GO:0006730,GO:0008270,GO:0015701 carbonate dehydratase activity|mitochondrion|mitochondrial matrix|one-carbon metabolic process|zinc ion binding|bicarbonate transport hsa00910 Nitrogen metabolism CA6 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0354262 GeneID:765,Genbank:NM_001215.3,HGNC:HGNC:1380,MIM:114780 carbonic anhydrase 6 GO:0001580,GO:0004089,GO:0005576,GO:0005615,GO:0006730,GO:0008270,GO:0015701,GO:0070062 detection of chemical stimulus involved in sensory perception of bitter taste|carbonate dehydratase activity|extracellular region|extracellular space|one-carbon metabolic process|zinc ion binding|bicarbonate transport|extracellular exosome hsa00910 Nitrogen metabolism CA7 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0220875 GeneID:766,Genbank:NM_005182.2,HGNC:HGNC:1381,MIM:114770 carbonic anhydrase 7 GO:0004089,GO:0005829,GO:0006730,GO:0008270,GO:0015701,GO:0032230,GO:0032849,GO:2001225 carbonate dehydratase activity|cytosol|one-carbon metabolic process|zinc ion binding|bicarbonate transport|positive regulation of synaptic transmission, GABAergic|positive regulation of cellular pH reduction|regulation of chloride transport hsa00910 Nitrogen metabolism CA8 32.3371109699533 30.7490198086201 33.9252021312864 1.103293774645 0.141816989290237 0.806681213329019 1 0.0682818 0.104299 0.142001 0.0703759 GeneID:767,Genbank:NM_001321839.1,HGNC:HGNC:1382,MIM:114815 carbonic anhydrase 8 GO:0004089,GO:0005737,GO:0006730,GO:0008270,GO:0048015 carbonate dehydratase activity|cytoplasm|one-carbon metabolic process|zinc ion binding|phosphatidylinositol-mediated signaling hsa00910 Nitrogen metabolism CA9 158.103947141612 132.105522117823 184.102372165402 1.39360088218874 0.478817442316433 0.432483372215224 1 3.43427 3.55093 3.30118 6.51479 GeneID:768,Genbank:NM_001216.2,HGNC:HGNC:1383,MIM:603179 carbonic anhydrase 9 GO:0002009,GO:0004089,GO:0005730,GO:0005886,GO:0006730,GO:0008270,GO:0015701,GO:0016021,GO:0016323,GO:0031528,GO:0033574,GO:0042493,GO:0046903,GO:0061418 morphogenesis of an epithelium|carbonate dehydratase activity|nucleolus|plasma membrane|one-carbon metabolic process|zinc ion binding|bicarbonate transport|integral component of membrane|basolateral plasma membrane|microvillus membrane|response to testosterone|response to drug|secretion|regulation of transcription from RNA polymerase II promoter in response to hypoxia hsa00910 Nitrogen metabolism CAAP1 711.390847067036 767.552230311993 655.229463822078 0.853661077312929 -0.22826469381387 0.16470732111104 1 12.2981 11.7255 10.7378 9.63912 GeneID:79886,Genbank:NM_024828.3,HGNC:HGNC:25834 caspase activity and apoptosis inhibitor 1 GO:0006915 apoptotic process CAB39 825.133270418382 878.180854637954 772.085686198809 0.879187563838562 -0.185757115464784 0.295438879786409 1 4.78028 4.40831 4.68485 3.57134 GeneID:51719,Genbank:NM_016289.3,HGNC:HGNC:20292,MIM:612174 calcium binding protein 39 GO:0004674,GO:0005576,GO:0005829,GO:0007050,GO:0010800,GO:0018105,GO:0019900,GO:0023014,GO:0030295,GO:0034774,GO:0035556,GO:0043234,GO:0043312,GO:0043539,GO:0051291,GO:0070062,GO:0071476,GO:0071902,GO:1901017,GO:1901380,GO:1902554,GO:1904813,GO:2000681,GO:2000687 protein serine/threonine kinase activity|extracellular region|cytosol|cell cycle arrest|positive regulation of peptidyl-threonine phosphorylation|peptidyl-serine phosphorylation|kinase binding|signal transduction by protein phosphorylation|protein kinase activator activity|secretory granule lumen|intracellular signal transduction|protein complex|neutrophil degranulation|protein serine/threonine kinase activator activity|protein heterooligomerization|extracellular exosome|cellular hypotonic response|positive regulation of protein serine/threonine kinase activity|negative regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transport|serine/threonine protein kinase complex|ficolin-1-rich granule lumen|negative regulation of rubidium ion transport|negative regulation of rubidium ion transmembrane transporter activity hsa04150,hsa04152 mTOR signaling pathway|AMPK signaling pathway CAB39L 166.698818792212 161.816564192735 171.581073391688 1.06034307580108 0.0845311267476003 0.732745420664768 1 1.16692 1.15488 1.50251 1.00298 GeneID:81617,Genbank:XM_011535256.3,HGNC:HGNC:20290,MIM:612175 calcium binding protein 39 like GO:0005829,GO:0007050,GO:0070062 cytosol|cell cycle arrest|extracellular exosome hsa04150,hsa04152 mTOR signaling pathway|AMPK signaling pathway CABCOCO1 4.47743817634329 3.6226049124413 5.33227144024528 1.47194396549631 0.5577227513954 0.756360152104437 1 0.0311529 0.0302412 0.0503336 0.0280667 GeneID:219621,Genbank:XM_005269600.4,HGNC:HGNC:28678 ciliary associated calcium binding coiled-coil 1 GO:0005509,GO:0005737,GO:0005813,GO:0036126 calcium ion binding|cytoplasm|centrosome|sperm flagellum CABIN1 1441.50319933802 1226.50188356663 1656.5045151094 1.35059272007992 0.433592686279861 0.00305225023650943 0.207139151643793 2.56025 2.72801 3.84649 3.52293 GeneID:23523,Genbank:XM_005261419.2,HGNC:HGNC:24187,MIM:604251 calcineurin binding protein 1 GO:0004864,GO:0005634,GO:0005654,GO:0005829,GO:0006336,GO:0007166,GO:0016235,GO:0016569 protein phosphatase inhibitor activity|nucleus|nucleoplasm|cytosol|DNA replication-independent nucleosome assembly|cell surface receptor signaling pathway|aggresome|covalent chromatin modification CABLES1 201.738990153493 222.228599801583 181.249380505403 0.815598805316829 -0.294068432780459 0.203595991854432 1 1.87382 1.70466 1.5253 1.47464 GeneID:91768,Genbank:NM_001256438.1,HGNC:HGNC:25097,MIM:609194 Cdk5 and Abl enzyme substrate 1 GO:0005634,GO:0005829,GO:0007049,GO:0007399,GO:0051301,GO:0051726 nucleus|cytosol|cell cycle|nervous system development|cell division|regulation of cell cycle CABLES2 484.14289882107 417.725820560429 550.55997708171 1.31799364555217 0.398343414691582 0.0252129535032622 0.631315976879816 4.22025 4.65694 6.43681 5.60276 GeneID:81928,Genbank:NM_031215.2,HGNC:HGNC:16143 Cdk5 and Abl enzyme substrate 2 GO:0007049,GO:0051301,GO:0051726 cell cycle|cell division|regulation of cell cycle CABP1 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.0153389 0.00679814 0 0 GeneID:9478,Genbank:XM_017020235.1,HGNC:HGNC:1384,MIM:605563 calcium binding protein 1 GO:0000139,GO:0004857,GO:0005509,GO:0005615,GO:0005856,GO:0005886,GO:0005938,GO:0008139,GO:0014069,GO:0030054,GO:0042308,GO:0045211,GO:0048306,GO:0048471 Golgi membrane|enzyme inhibitor activity|calcium ion binding|extracellular space|cytoskeleton|plasma membrane|cell cortex|nuclear localization sequence binding|postsynaptic density|cell junction|negative regulation of protein import into nucleus|postsynaptic membrane|calcium-dependent protein binding|perinuclear region of cytoplasm CABP4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00498658 0 GeneID:57010,Genbank:XM_017018025.1,HGNC:HGNC:1386,MIM:608965 calcium binding protein 4 GO:0005246,GO:0005509,GO:0005576,GO:0005829,GO:0007165,GO:0007601,GO:0007602,GO:0008594,GO:0043195,GO:0044325,GO:0045202,GO:0046549,GO:0060040 calcium channel regulator activity|calcium ion binding|extracellular region|cytosol|signal transduction|visual perception|phototransduction|photoreceptor cell morphogenesis|terminal bouton|ion channel binding|synapse|retinal cone cell development|retinal bipolar neuron differentiation CABP7 21.4349046500842 26.8764748676462 15.9933344325223 0.595068159469641 -0.748873169833091 0.234996446878585 1 0.352042 0.267402 0.20373 0.139962 GeneID:164633,Genbank:NM_182527.2,HGNC:HGNC:20834 calcium binding protein 7 GO:0005509,GO:0005886,GO:0016021,GO:0032588,GO:0048471 calcium ion binding|plasma membrane|integral component of membrane|trans-Golgi network membrane|perinuclear region of cytoplasm CABYR 1.50736430976325 1.07619535328461 1.93853326624189 1.801283809975 0.849025509942274 0.867041039883367 1 0.0254467 0 0 0 GeneID:26256,Genbank:NM_012189.3,HGNC:HGNC:15569,MIM:612135 calcium binding tyrosine phosphorylation regulated GO:0003351,GO:0005509,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0017124,GO:0019899,GO:0031514,GO:0035686,GO:0046982,GO:0048240,GO:0097228,GO:0097229 epithelial cilium movement|calcium ion binding|nucleus|cytoplasm|cytosol|cytoskeleton|SH3 domain binding|enzyme binding|motile cilium|sperm fibrous sheath|protein heterodimerization activity|sperm capacitation|sperm principal piece|sperm end piece CACFD1 200.104004508386 172.9441276137 227.263881403072 1.31408845468697 0.394062390457161 0.111936021266093 1 1.51373 1.56552 1.92625 2.28796 GeneID:11094,Genbank:NM_001242369.1,HGNC:HGNC:1365,MIM:613104 calcium channel flower domain containing 1 GO:0016021,GO:0016192 integral component of membrane|vesicle-mediated transport CACHD1 165.740418735226 165.237255351329 166.243582119123 1.00609019295107 0.00875964419967951 0.968858647699621 1 0.924611 0.809068 1.00246 0.818879 GeneID:57685,Genbank:NM_020925.2,HGNC:HGNC:29314 cache domain containing 1 GO:0006816,GO:0016021 calcium ion transport|integral component of membrane CACNA1A 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0 0 0.0043968 0 GeneID:773,Genbank:NM_001127222.1,HGNC:HGNC:1388,MIM:601011 calcium voltage-gated channel subunit alpha1 A hsa04010,hsa04020,hsa04721,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04742,hsa04930,hsa05032,hsa05033 MAPK signaling pathway|Calcium signaling pathway|Synaptic vesicle cycle|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Type II diabetes mellitus|Morphine addiction|Nicotine addiction CACNA1B 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0 0 GeneID:774,Genbank:NM_000718.3,HGNC:HGNC:1389,MIM:601012 calcium voltage-gated channel subunit alpha1 B GO:0005245,GO:0005262,GO:0005509,GO:0005524,GO:0005886,GO:0005891,GO:0006810,GO:0007268,GO:0007269,GO:0007626,GO:0008016,GO:0008022,GO:0008217,GO:0008331,GO:0030425,GO:0034765,GO:0043025,GO:0048265,GO:0051899,GO:0051924,GO:0086010,GO:0098793 voltage-gated calcium channel activity|calcium channel activity|calcium ion binding|ATP binding|plasma membrane|voltage-gated calcium channel complex|transport|chemical synaptic transmission|neurotransmitter secretion|locomotory behavior|regulation of heart contraction|protein C-terminus binding|regulation of blood pressure|high voltage-gated calcium channel activity|dendrite|regulation of ion transmembrane transport|neuronal cell body|response to pain|membrane depolarization|regulation of calcium ion transport|membrane depolarization during action potential|presynapse hsa04010,hsa04020,hsa04721,hsa04723,hsa04725,hsa04726,hsa04727,hsa04728,hsa04930,hsa05032,hsa05033 MAPK signaling pathway|Calcium signaling pathway|Synaptic vesicle cycle|Retrograde endocannabinoid signaling|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Type II diabetes mellitus|Morphine addiction|Nicotine addiction CACNA1C 0.99578132014851 0.538097676642304 1.45346496365472 2.70111733751434 1.43355631240266 0.835241087836065 1 0.00247349 0 0.00233615 0.00436293 GeneID:775,Genbank:XM_017019926.2,HGNC:HGNC:1390,MIM:114205 calcium voltage-gated channel subunit alpha1 C GO:0002520,GO:0005245,GO:0005516,GO:0005737,GO:0005886,GO:0005891,GO:0007204,GO:0007507,GO:0008331,GO:0010881,GO:0014069,GO:0016021,GO:0030018,GO:0035115,GO:0035585,GO:0043010,GO:0046872,GO:0050796,GO:0051393,GO:0060402,GO:0061337,GO:0061577,GO:0070588,GO:0086002,GO:0086007,GO:0086012,GO:0086045,GO:0086056,GO:0086064,GO:0086091,GO:0098911,GO:0098912,GO:1990454 immune system development|voltage-gated calcium channel activity|calmodulin binding|cytoplasm|plasma membrane|voltage-gated calcium channel complex|positive regulation of cytosolic calcium ion concentration|heart development|high voltage-gated calcium channel activity|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|postsynaptic density|integral component of membrane|Z disc|embryonic forelimb morphogenesis|calcium-mediated signaling using extracellular calcium source|camera-type eye development|metal ion binding|regulation of insulin secretion|alpha-actinin binding|calcium ion transport into cytosol|cardiac conduction|calcium ion transmembrane transport via high voltage-gated calcium channel|calcium ion transmembrane transport|cardiac muscle cell action potential involved in contraction|voltage-gated calcium channel activity involved in cardiac muscle cell action potential|membrane depolarization during cardiac muscle cell action potential|membrane depolarization during AV node cell action potential|voltage-gated calcium channel activity involved in AV node cell action potential|cell communication by electrical coupling involved in cardiac conduction|regulation of heart rate by cardiac conduction|regulation of ventricular cardiac muscle cell action potential|membrane depolarization during atrial cardiac muscle cell action potential|L-type voltage-gated calcium channel complex hsa04010,hsa04020,hsa04022,hsa04024,hsa04260,hsa04261,hsa04270,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04742,hsa04911,hsa04912,hsa04921,hsa04924,hsa04925,hsa04927,hsa04930,hsa04934,hsa05010,hsa05031,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Taste transduction|Insulin secretion|GnRH signaling pathway|Oxytocin signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Type II diabetes mellitus|Cushing syndrome|Alzheimer disease|Amphetamine addiction|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNA1D 16.2523410398512 17.4788743361943 15.0258077435081 0.859655344760587 -0.218169728174079 0.799043026393142 1 0.0561974 0.044418 0.06852 0.0354466 GeneID:776,Genbank:NM_001128840.2,HGNC:HGNC:1391,MIM:114206 calcium voltage-gated channel subunit alpha1 D GO:0005245,GO:0005262,GO:0005886,GO:0005891,GO:0006816,GO:0007188,GO:0007605,GO:0008331,GO:0030018,GO:0030506,GO:0046872,GO:0050796,GO:0051393,GO:0051928,GO:0060372,GO:0061337,GO:0070509,GO:0070588,GO:0086002,GO:0086007,GO:0086012,GO:0086046,GO:0086059,GO:0086091,GO:1901016,GO:1901379,GO:1990454 voltage-gated calcium channel activity|calcium channel activity|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|sensory perception of sound|high voltage-gated calcium channel activity|Z disc|ankyrin binding|metal ion binding|regulation of insulin secretion|alpha-actinin binding|positive regulation of calcium ion transport|regulation of atrial cardiac muscle cell membrane repolarization|cardiac conduction|calcium ion import|calcium ion transmembrane transport|cardiac muscle cell action potential involved in contraction|voltage-gated calcium channel activity involved in cardiac muscle cell action potential|membrane depolarization during cardiac muscle cell action potential|membrane depolarization during SA node cell action potential|voltage-gated calcium channel activity involved SA node cell action potential|regulation of heart rate by cardiac conduction|regulation of potassium ion transmembrane transporter activity|regulation of potassium ion transmembrane transport|L-type voltage-gated calcium channel complex hsa04010,hsa04020,hsa04022,hsa04024,hsa04218,hsa04260,hsa04261,hsa04270,hsa04530,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04911,hsa04912,hsa04921,hsa04924,hsa04925,hsa04927,hsa04930,hsa04934,hsa04973,hsa05010,hsa05031,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cellular senescence|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Tight junction|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Insulin secretion|GnRH signaling pathway|Oxytocin signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Type II diabetes mellitus|Cushing syndrome|Carbohydrate digestion and absorption|Alzheimer disease|Amphetamine addiction|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNA1E 4.46005971600271 5.04479284362845 3.87532658837698 0.768183493058887 -0.380477131718655 0.850733712639942 1 0.00479545 0.01321 0.00227139 0.0127073 GeneID:777,Genbank:XM_017002244.1,HGNC:HGNC:1392,MIM:601013 calcium voltage-gated channel subunit alpha1 E GO:0005245,GO:0005262,GO:0005509,GO:0005886,GO:0005891,GO:0006810,GO:0007268,GO:0008331,GO:0034765,GO:0050796,GO:0051899,GO:0086010 voltage-gated calcium channel activity|calcium channel activity|calcium ion binding|plasma membrane|voltage-gated calcium channel complex|transport|chemical synaptic transmission|high voltage-gated calcium channel activity|regulation of ion transmembrane transport|regulation of insulin secretion|membrane depolarization|membrane depolarization during action potential hsa04010,hsa04020,hsa04930 MAPK signaling pathway|Calcium signaling pathway|Type II diabetes mellitus CACNA1F 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00680131 0 0 0 GeneID:778,Genbank:XM_011543983.2,HGNC:HGNC:1393,MIM:300110 calcium voltage-gated channel subunit alpha1 F hsa04010,hsa04020,hsa04022,hsa04024,hsa04260,hsa04261,hsa04270,hsa04723,hsa04725,hsa04726,hsa04727,hsa04911,hsa04912,hsa04921,hsa04924,hsa04925,hsa04927,hsa04934,hsa05010,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Retrograde endocannabinoid signaling|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Insulin secretion|GnRH signaling pathway|Oxytocin signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome|Alzheimer disease|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNA1G 4.90229907537164 1.56626675524197 8.23833139550132 5.25985204495296 2.39502221833607 0.107449097735142 1 0.00484548 0.00421127 0.0359362 0.0209704 GeneID:8913,Genbank:XM_006722160.4,HGNC:HGNC:1394,MIM:604065 calcium voltage-gated channel subunit alpha1 G GO:0005248,GO:0005737,GO:0005886,GO:0005891,GO:0007268,GO:0008332,GO:0010045,GO:0019228,GO:0034765,GO:0042391,GO:0045956,GO:0060371,GO:0070509,GO:0070588,GO:0086002,GO:0086010,GO:0086015,GO:0086016,GO:0086018,GO:0086027,GO:0086045,GO:0086046,GO:0086056,GO:0086059,GO:0086091,GO:0097110 voltage-gated sodium channel activity|cytoplasm|plasma membrane|voltage-gated calcium channel complex|chemical synaptic transmission|low voltage-gated calcium channel activity|response to nickel cation|neuronal action potential|regulation of ion transmembrane transport|regulation of membrane potential|positive regulation of calcium ion-dependent exocytosis|regulation of atrial cardiac muscle cell membrane depolarization|calcium ion import|calcium ion transmembrane transport|cardiac muscle cell action potential involved in contraction|membrane depolarization during action potential|SA node cell action potential|AV node cell action potential|SA node cell to atrial cardiac muscle cell signaling|AV node cell to bundle of His cell signaling|membrane depolarization during AV node cell action potential|membrane depolarization during SA node cell action potential|voltage-gated calcium channel activity involved in AV node cell action potential|voltage-gated calcium channel activity involved SA node cell action potential|regulation of heart rate by cardiac conduction|scaffold protein binding hsa04010,hsa04020,hsa04713,hsa04925,hsa04927,hsa04930,hsa04934 MAPK signaling pathway|Calcium signaling pathway|Circadian entrainment|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Type II diabetes mellitus|Cushing syndrome CACNA1H 1.51236740913344 2.05633815719933 0.968396661067546 0.470932593298016 -1.08640751970762 0.811664485952849 1 0 0.00501046 0 0.0102266 GeneID:8912,Genbank:NM_021098.2,HGNC:HGNC:1395,MIM:607904 calcium voltage-gated channel subunit alpha1 H GO:0005244,GO:0005248,GO:0005886,GO:0005887,GO:0005891,GO:0006936,GO:0007517,GO:0007520,GO:0008016,GO:0008332,GO:0016021,GO:0019228,GO:0032342,GO:0032870,GO:0034651,GO:0034765,GO:0035865,GO:0042391,GO:0045956,GO:0046872,GO:0070509,GO:0086010,GO:0097110,GO:0098662,GO:2000344 voltage-gated ion channel activity|voltage-gated sodium channel activity|plasma membrane|integral component of plasma membrane|voltage-gated calcium channel complex|muscle contraction|muscle organ development|myoblast fusion|regulation of heart contraction|low voltage-gated calcium channel activity|integral component of membrane|neuronal action potential|aldosterone biosynthetic process|cellular response to hormone stimulus|cortisol biosynthetic process|regulation of ion transmembrane transport|cellular response to potassium ion|regulation of membrane potential|positive regulation of calcium ion-dependent exocytosis|metal ion binding|calcium ion import|membrane depolarization during action potential|scaffold protein binding|inorganic cation transmembrane transport|positive regulation of acrosome reaction hsa04010,hsa04020,hsa04713,hsa04925,hsa04927,hsa04934 MAPK signaling pathway|Calcium signaling pathway|Circadian entrainment|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome CACNA1I 1.97679409611663 2.49838328447175 1.45520490776151 0.582458631069969 -0.77977250841594 0.825694118379557 1 0.00321927 0.00842507 0.0059897 0 GeneID:8911,Genbank:NM_021096.3,HGNC:HGNC:1396,MIM:608230 calcium voltage-gated channel subunit alpha1 I GO:0005245,GO:0005248,GO:0005886,GO:0005891,GO:0006810,GO:0007165,GO:0008332,GO:0019228,GO:0030317,GO:0030431,GO:0034765,GO:0045956,GO:0070509,GO:0086010 voltage-gated calcium channel activity|voltage-gated sodium channel activity|plasma membrane|voltage-gated calcium channel complex|transport|signal transduction|low voltage-gated calcium channel activity|neuronal action potential|flagellated sperm motility|sleep|regulation of ion transmembrane transport|positive regulation of calcium ion-dependent exocytosis|calcium ion import|membrane depolarization during action potential hsa04010,hsa04020,hsa04713,hsa04925,hsa04927,hsa04934 MAPK signaling pathway|Calcium signaling pathway|Circadian entrainment|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome CACNA2D1 118.714467156068 109.946447825263 127.482486486872 1.15949618208201 0.213498069573902 0.622925471865056 1 0.359119 0.228716 0.43097 0.235303 GeneID:781,Genbank:NM_000722.3,HGNC:HGNC:1399,MIM:114204 calcium voltage-gated channel auxiliary subunit alpha2delta 1 GO:0005245,GO:0005886,GO:0005891,GO:0006816,GO:0016529,GO:0046872,GO:0051924,GO:0060307,GO:0060402,GO:0061337,GO:0061577,GO:0070062,GO:0086002,GO:0086048,GO:0086091,GO:0098703,GO:0098903,GO:1901843,GO:1902514,GO:1904646,GO:1990454 voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|sarcoplasmic reticulum|metal ion binding|regulation of calcium ion transport|regulation of ventricular cardiac muscle cell membrane repolarization|calcium ion transport into cytosol|cardiac conduction|calcium ion transmembrane transport via high voltage-gated calcium channel|extracellular exosome|cardiac muscle cell action potential involved in contraction|membrane depolarization during bundle of His cell action potential|regulation of heart rate by cardiac conduction|calcium ion import across plasma membrane|regulation of membrane repolarization during action potential|positive regulation of high voltage-gated calcium channel activity|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|cellular response to amyloid-beta|L-type voltage-gated calcium channel complex hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNA2D2 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0.00678965 0 0 0 GeneID:9254,Genbank:NM_001291101.1,HGNC:HGNC:1400,MIM:607082 calcium voltage-gated channel auxiliary subunit alpha2delta 2 GO:0005245,GO:0005886,GO:0005891,GO:0007528,GO:0034765,GO:0040014,GO:0046622,GO:0046872,GO:0048747,GO:0050796,GO:0060024,GO:0061337 voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|neuromuscular junction development|regulation of ion transmembrane transport|regulation of multicellular organism growth|positive regulation of organ growth|metal ion binding|muscle fiber development|regulation of insulin secretion|rhythmic synaptic transmission|cardiac conduction hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNA2D3 19.0853832445513 17.8248669140969 20.3458995750058 1.14143346332169 0.190846764132413 0.853189240267553 1 0.0543328 0.0696942 0.0141984 0.0792555 GeneID:55799,Genbank:XM_011533946.2,HGNC:HGNC:15460,MIM:606399 calcium voltage-gated channel auxiliary subunit alpha2delta 3 GO:0005244,GO:0005262,GO:0005886,GO:0016021,GO:0034765,GO:0046872,GO:0061337 voltage-gated ion channel activity|calcium channel activity|plasma membrane|integral component of membrane|regulation of ion transmembrane transport|metal ion binding|cardiac conduction hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNA2D4 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0 0 0 0 GeneID:93589,Genbank:NM_172364.4,HGNC:HGNC:20202,MIM:608171 calcium voltage-gated channel auxiliary subunit alpha2delta 4 GO:0005245,GO:0005886,GO:0005891,GO:0034765,GO:0046872,GO:0050908,GO:0061337,GO:0070588 voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|regulation of ion transmembrane transport|metal ion binding|detection of light stimulus involved in visual perception|cardiac conduction|calcium ion transmembrane transport hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNB1 99.8075011716474 107.045254033951 92.5697483093437 0.864772092371174 -0.209608129223873 0.469630980833129 1 0.570121 0.764659 0.674954 0.439698 GeneID:782,Genbank:NM_000723.4,HGNC:HGNC:1401,MIM:114207 calcium voltage-gated channel auxiliary subunit beta 1 GO:0005245,GO:0005886,GO:0005891,GO:0006810,GO:0007268,GO:0007528,GO:0008331,GO:0042383,GO:0061337,GO:1901385,GO:1902514,GO:1904646 voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|transport|chemical synaptic transmission|neuromuscular junction development|high voltage-gated calcium channel activity|sarcolemma|cardiac conduction|regulation of voltage-gated calcium channel activity|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|cellular response to amyloid-beta hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNB2 11.1717030504117 9.253521707397 13.0898843934264 1.41458406943194 0.50037791936295 0.590787623594034 1 0.0255126 0.024231 0.0570191 0.0228221 GeneID:783,Genbank:NM_201596.2,HGNC:HGNC:1402,MIM:600003 calcium voltage-gated channel auxiliary subunit beta 2 GO:0005245,GO:0005262,GO:0005886,GO:0005887,GO:0005891,GO:0007268,GO:0007528,GO:0007601,GO:0051015,GO:0051928,GO:0061337,GO:0070509,GO:0072659,GO:0086045,GO:0086091,GO:0098912,GO:1901385,GO:1901843,GO:1904879,GO:1990454 voltage-gated calcium channel activity|calcium channel activity|plasma membrane|integral component of plasma membrane|voltage-gated calcium channel complex|chemical synaptic transmission|neuromuscular junction development|visual perception|actin filament binding|positive regulation of calcium ion transport|cardiac conduction|calcium ion import|protein localization to plasma membrane|membrane depolarization during AV node cell action potential|regulation of heart rate by cardiac conduction|membrane depolarization during atrial cardiac muscle cell action potential|regulation of voltage-gated calcium channel activity|positive regulation of high voltage-gated calcium channel activity|positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|L-type voltage-gated calcium channel complex hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNB3 771.527595173818 711.916447208881 831.138743138755 1.16746669696605 0.22338139635275 0.161744541301842 1 4.14961 4.10945 5.04056 4.89106 GeneID:784,Genbank:NM_001206917.1,HGNC:HGNC:1403,MIM:601958 calcium voltage-gated channel auxiliary subunit beta 3 GO:0005245,GO:0005262,GO:0005829,GO:0005886,GO:0005891,GO:0006810,GO:0006816,GO:0007268,GO:0007528,GO:0008331,GO:0016020,GO:0016324,GO:0019901,GO:0050852,GO:0051899,GO:0060402,GO:0061337,GO:0061577,GO:0072659,GO:0098903,GO:1901385,GO:1990454 voltage-gated calcium channel activity|calcium channel activity|cytosol|plasma membrane|voltage-gated calcium channel complex|transport|calcium ion transport|chemical synaptic transmission|neuromuscular junction development|high voltage-gated calcium channel activity|membrane|apical plasma membrane|protein kinase binding|T cell receptor signaling pathway|membrane depolarization|calcium ion transport into cytosol|cardiac conduction|calcium ion transmembrane transport via high voltage-gated calcium channel|protein localization to plasma membrane|regulation of membrane repolarization during action potential|regulation of voltage-gated calcium channel activity|L-type voltage-gated calcium channel complex hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNB4 23.5685750110579 22.417805975345 24.7193440467709 1.10266562543887 0.140995371477066 0.81178527816128 1 0.0452118 0.0307959 0.0503262 0.0448345 GeneID:785,Genbank:NM_001145798.2,HGNC:HGNC:1404,MIM:601949 calcium voltage-gated channel auxiliary subunit beta 4 GO:0005262,GO:0005829,GO:0005886,GO:0005891,GO:0006810,GO:0007268,GO:0007528,GO:0008331,GO:0009898,GO:0045202,GO:0051899,GO:0061337,GO:0070588,GO:1901385 calcium channel activity|cytosol|plasma membrane|voltage-gated calcium channel complex|transport|chemical synaptic transmission|neuromuscular junction development|high voltage-gated calcium channel activity|cytoplasmic side of plasma membrane|synapse|membrane depolarization|cardiac conduction|calcium ion transmembrane transport|regulation of voltage-gated calcium channel activity hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNG1 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0942648 0 0 0 GeneID:786,Genbank:NM_000727.3,HGNC:HGNC:1405,MIM:114209 calcium voltage-gated channel auxiliary subunit gamma 1 GO:0005245,GO:0005886,GO:0005891,GO:0006810,GO:0006936,GO:0034765,GO:0061337,GO:0070296 voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|transport|muscle contraction|regulation of ion transmembrane transport|cardiac conduction|sarcoplasmic reticulum calcium ion transport hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNG4 1123.6188562885 1010.77848215944 1236.45923041756 1.22327419136977 0.29074781367151 0.23127802896185 1 11.9894 12.6841 18.2849 12.7009 GeneID:27092,Genbank:NM_014405.3,HGNC:HGNC:1408,MIM:606404 calcium voltage-gated channel auxiliary subunit gamma 4 GO:0005245,GO:0005262,GO:0005886,GO:0005887,GO:0005891,GO:0006810,GO:0016247,GO:0019226,GO:0030666,GO:0032281,GO:0036477,GO:0051899,GO:0061337,GO:0070588,GO:2000311 voltage-gated calcium channel activity|calcium channel activity|plasma membrane|integral component of plasma membrane|voltage-gated calcium channel complex|transport|channel regulator activity|transmission of nerve impulse|endocytic vesicle membrane|AMPA glutamate receptor complex|somatodendritic compartment|membrane depolarization|cardiac conduction|calcium ion transmembrane transport|regulation of AMPA receptor activity hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNG7 3.52587662311453 2.69048838321152 4.36126486301754 1.62099375348787 0.696878531429518 0.712668566123601 1 0.111778 0 0.0618809 0.0581185 GeneID:59284,Genbank:XM_017027093.1,HGNC:HGNC:13626,MIM:606899 calcium voltage-gated channel auxiliary subunit gamma 7 GO:0005245,GO:0016247,GO:0019226,GO:0032281,GO:0070588,GO:2000311 voltage-gated calcium channel activity|channel regulator activity|transmission of nerve impulse|AMPA glutamate receptor complex|calcium ion transmembrane transport|regulation of AMPA receptor activity hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACNG8 16.5761462901395 14.2502882763405 18.9020043039385 1.32642960881859 0.40754811642382 0.597548512520889 1 0.0459123 0.0610897 0.0830021 0.0662727 GeneID:59283,Genbank:NM_031895.5,HGNC:HGNC:13628,MIM:606900 calcium voltage-gated channel auxiliary subunit gamma 8 GO:0005245,GO:0005886,GO:0005891,GO:0006816,GO:0014069,GO:0016247,GO:0019226,GO:0030054,GO:0030666,GO:0032281,GO:0045211,GO:0061337,GO:0070588,GO:2000311 voltage-gated calcium channel activity|plasma membrane|voltage-gated calcium channel complex|calcium ion transport|postsynaptic density|channel regulator activity|transmission of nerve impulse|cell junction|endocytic vesicle membrane|AMPA glutamate receptor complex|postsynaptic membrane|cardiac conduction|calcium ion transmembrane transport|regulation of AMPA receptor activity hsa04010,hsa04260,hsa04261,hsa04921,hsa05410,hsa05412,hsa05414 MAPK signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Oxytocin signaling pathway|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) CACTIN 1178.35755879409 1153.40582643669 1203.30929115149 1.04326618053333 0.0611072962487225 0.698491739525955 1 9.71712 10.0383 10.496 10.483 GeneID:58509,Genbank:NM_001080543.1,HGNC:HGNC:29938 cactin, spliceosome C complex subunit GO:0000398,GO:0001933,GO:0003723,GO:0005634,GO:0005654,GO:0005829,GO:0007275,GO:0016607,GO:0031665,GO:0032088,GO:0032688,GO:0032717,GO:0032720,GO:0034122,GO:0045087,GO:0060339,GO:0070062,GO:0071013,GO:0071222,GO:0071347,GO:0071356 mRNA splicing, via spliceosome|negative regulation of protein phosphorylation|RNA binding|nucleus|nucleoplasm|cytosol|multicellular organism development|nuclear speck|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-beta production|negative regulation of interleukin-8 production|negative regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|innate immune response|negative regulation of type I interferon-mediated signaling pathway|extracellular exosome|catalytic step 2 spliceosome|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor CACUL1 1221.87201613459 1376.00679377893 1067.73723849025 0.775967999080815 -0.365930937989618 0.026735118973059 0.655726899651628 9.95325 9.10657 8.39301 6.52707 GeneID:143384,Genbank:NM_153810.4,HGNC:HGNC:23727 CDK2 associated cullin domain 1 GO:0000082,GO:0008284,GO:0019901,GO:0031461,GO:0031625,GO:0042787,GO:0045860 G1/S transition of mitotic cell cycle|positive regulation of cell proliferation|protein kinase binding|cullin-RING ubiquitin ligase complex|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of protein kinase activity CACYBP 2655.09007094545 2849.74072730208 2460.43941458882 0.863390620422572 -0.211914674943385 0.124372374544603 1 25.5995 27.4951 23.8219 23.2163 GeneID:27101,Genbank:NM_001007214.1,HGNC:HGNC:30423,MIM:606186 calcyclin binding protein GO:0005641,GO:0005654,GO:0005829,GO:0007568,GO:0019005,GO:0019904,GO:0030877,GO:0031625,GO:0042803,GO:0043005,GO:0044297,GO:0045740,GO:0055007,GO:0060416,GO:0060548,GO:0070062,GO:0071277,GO:1990830 nuclear envelope lumen|nucleoplasm|cytosol|aging|SCF ubiquitin ligase complex|protein domain specific binding|beta-catenin destruction complex|ubiquitin protein ligase binding|protein homodimerization activity|neuron projection|cell body|positive regulation of DNA replication|cardiac muscle cell differentiation|response to growth hormone|negative regulation of cell death|extracellular exosome|cellular response to calcium ion|cellular response to leukemia inhibitory factor hsa04310 Wnt signaling pathway CAD 2458.9296490166 2481.12994214358 2436.72935588962 0.982104691294163 -0.0260512724243747 0.834315246002891 1 12.4297 13.2396 13.4378 12.4075 GeneID:790,Genbank:NM_004341.4,HGNC:HGNC:1424,MIM:114010 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase hsa00240,hsa00250 Pyrimidine metabolism|Alanine, aspartate and glutamate metabolism CADM1 2063.41380241904 2011.34967477034 2115.47793006774 1.05177033939128 0.0728197175649488 0.599045752597427 1 14.0764 13.6104 15.7082 13.5804 GeneID:23705,Genbank:NM_001098517.1,HGNC:HGNC:5951,MIM:605686 cell adhesion molecule 1 GO:0002376,GO:0004872,GO:0005102,GO:0005886,GO:0005887,GO:0005911,GO:0005913,GO:0006915,GO:0007156,GO:0007157,GO:0007275,GO:0007283,GO:0008037,GO:0016323,GO:0030154,GO:0030165,GO:0034332,GO:0042271,GO:0042803,GO:0045202,GO:0045954,GO:0050715,GO:0050839,GO:0051606,GO:0070062 immune system process|receptor activity|receptor binding|plasma membrane|integral component of plasma membrane|cell-cell junction|cell-cell adherens junction|apoptotic process|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|multicellular organism development|spermatogenesis|cell recognition|basolateral plasma membrane|cell differentiation|PDZ domain binding|adherens junction organization|susceptibility to natural killer cell mediated cytotoxicity|protein homodimerization activity|synapse|positive regulation of natural killer cell mediated cytotoxicity|positive regulation of cytokine secretion|cell adhesion molecule binding|detection of stimulus|extracellular exosome hsa04514 Cell adhesion molecules (CAMs) CADM2 46.8131961666418 32.0653465353294 61.5610457979541 1.91986217052501 0.941002741656018 0.0502073238166428 0.818859977848627 0.15463 0.112799 0.35805 0.202378 GeneID:253559,Genbank:NM_001167675.1,HGNC:HGNC:29849,MIM:609938 cell adhesion molecule 2 GO:0004872,GO:0005102,GO:0005886,GO:0005887,GO:0005913,GO:0007156,GO:0007157,GO:0008037,GO:0030424,GO:0034332,GO:0042803,GO:0045202,GO:0050839 receptor activity|receptor binding|plasma membrane|integral component of plasma membrane|cell-cell adherens junction|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell recognition|axon|adherens junction organization|protein homodimerization activity|synapse|cell adhesion molecule binding CADM3 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.00941884 0.00991512 0 GeneID:57863,Genbank:NM_021189.4,HGNC:HGNC:17601,MIM:609743 cell adhesion molecule 3 GO:0004872,GO:0005102,GO:0005886,GO:0005887,GO:0005911,GO:0005913,GO:0007156,GO:0007157,GO:0008037,GO:0008104,GO:0034332,GO:0042803,GO:0050839 receptor activity|receptor binding|plasma membrane|integral component of plasma membrane|cell-cell junction|cell-cell adherens junction|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell recognition|protein localization|adherens junction organization|protein homodimerization activity|cell adhesion molecule binding hsa04514 Cell adhesion molecules (CAMs) CADM4 733.532438825002 709.619977678256 757.444899971747 1.06739511822929 0.0940943182352859 0.563708433111139 1 12.4555 12.1002 12.9251 13.4856 GeneID:199731,Genbank:XM_017026452.1,HGNC:HGNC:30825,MIM:609744 cell adhesion molecule 4 GO:0004872,GO:0005102,GO:0005887,GO:0005913,GO:0007156,GO:0007157,GO:0008037,GO:0042803,GO:0050839,GO:0070062 receptor activity|receptor binding|integral component of plasma membrane|cell-cell adherens junction|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell recognition|protein homodimerization activity|cell adhesion molecule binding|extracellular exosome CADPS 2.4634939763355 2.98845468642911 1.93853326624189 0.648674137521632 -0.624434174821027 0.834473657512802 1 0.00528263 0.0195927 0.0100575 0.00467673 GeneID:8618,Genbank:NM_183393.2,HGNC:HGNC:1426,MIM:604667 calcium dependent secretion activator GO:0005829,GO:0006887,GO:0008289,GO:0015031,GO:0016050,GO:0016082,GO:0019901,GO:0030054,GO:0030659,GO:0046872,GO:0050432,GO:0098793,GO:0099525 cytosol|exocytosis|lipid binding|protein transport|vesicle organization|synaptic vesicle priming|protein kinase binding|cell junction|cytoplasmic vesicle membrane|metal ion binding|catecholamine secretion|presynapse|presynaptic dense core vesicle exocytosis CADPS2 191.759828952395 194.977723391565 188.541934513225 0.966992183689542 -0.0484238666101799 0.832743700278786 1 0.720511 0.940082 1.04061 0.728539 GeneID:93664,Genbank:NM_001009571.3,HGNC:HGNC:16018,MIM:609978 calcium dependent secretion activator 2 GO:0005654,GO:0008289,GO:0009267,GO:0015031,GO:0016082,GO:0030054,GO:0030659,GO:0042734,GO:0043231,GO:0045211,GO:0045921,GO:0046872,GO:1990504 nucleoplasm|lipid binding|cellular response to starvation|protein transport|synaptic vesicle priming|cell junction|cytoplasmic vesicle membrane|presynaptic membrane|intracellular membrane-bounded organelle|postsynaptic membrane|positive regulation of exocytosis|metal ion binding|dense core granule exocytosis CAGE1 2.7771975676031 3.13253351048394 2.42186162472226 0.773131912752662 -0.371213505268009 0.960658824905657 1 0.00943562 0 0 0 GeneID:285782,Genbank:NM_205864.2,HGNC:HGNC:21622,MIM:608304 cancer antigen 1 CALB1 82.7971932728249 86.1162625738393 79.4781239718105 0.922916550212139 -0.115727889094183 0.753812684240808 1 1.40545 1.27562 1.32403 1.26261 GeneID:793,Genbank:NM_004929.3,HGNC:HGNC:1434,MIM:114050 calbindin 1 hsa04961 Endocrine and other factor-regulated calcium reabsorption CALCOCO1 581.694494540429 528.114313512965 635.274675567892 1.20291130028669 0.266530265660806 0.227927501846747 1 3.80347 3.8415 3.86482 5.00214 GeneID:57658,Genbank:NM_020898.2,HGNC:HGNC:29306 calcium binding and coiled-coil domain 1 GO:0000790,GO:0001047,GO:0003682,GO:0003712,GO:0003713,GO:0005634,GO:0005829,GO:0006351,GO:0007165,GO:0008013,GO:0008022,GO:0010628,GO:0016055,GO:0030374,GO:0030518,GO:0043231,GO:0043565,GO:0044212,GO:0045893,GO:0045944,GO:0070016 nuclear chromatin|core promoter binding|chromatin binding|transcription cofactor activity|transcription coactivator activity|nucleus|cytosol|transcription, DNA-templated|signal transduction|beta-catenin binding|protein C-terminus binding|positive regulation of gene expression|Wnt signaling pathway|ligand-dependent nuclear receptor transcription coactivator activity|intracellular steroid hormone receptor signaling pathway|intracellular membrane-bounded organelle|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|armadillo repeat domain binding CALCOCO2 1477.58491775412 1397.51311753612 1557.65671797213 1.11459184062498 0.156515497311207 0.276927767741432 1 11.1954 11.5093 13.7878 11.8653 GeneID:10241,Genbank:NM_001261391.1,HGNC:HGNC:29912,MIM:604587 calcium binding and coiled-coil domain 2 GO:0000421,GO:0005634,GO:0005737,GO:0005776,GO:0005829,GO:0005856,GO:0016020,GO:0016032,GO:0031410,GO:0034341,GO:0042803,GO:0043231,GO:0048471,GO:0098792,GO:1901098 autophagosome membrane|nucleus|cytoplasm|autophagosome|cytosol|cytoskeleton|membrane|viral process|cytoplasmic vesicle|response to interferon-gamma|protein homodimerization activity|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|xenophagy|positive regulation of autophagosome maturation hsa04137 Mitophagy - animal CALCR 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:799,Genbank:NM_001742.3,HGNC:HGNC:1440,MIM:114131 calcitonin receptor GO:0004872,GO:0004948,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007189,GO:0007204,GO:0008565,GO:0010628,GO:0010739,GO:0010942,GO:0015031,GO:0030816,GO:0032841,GO:0033138,GO:0045762,GO:0051384,GO:0051897,GO:0070374,GO:0072659,GO:0097647,GO:1903440,GO:1905665 receptor activity|calcitonin receptor activity|intracellular|cell|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|protein transporter activity|positive regulation of gene expression|positive regulation of protein kinase A signaling|positive regulation of cell death|protein transport|positive regulation of cAMP metabolic process|calcitonin binding|positive regulation of peptidyl-serine phosphorylation|positive regulation of adenylate cyclase activity|response to glucocorticoid|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|protein localization to plasma membrane|amylin receptor signaling pathway|amylin receptor complex|positive regulation of calcium ion import across plasma membrane hsa04080,hsa04380 Neuroactive ligand-receptor interaction|Osteoclast differentiation CALCRL 165.380213600556 167.937552389648 162.822874811464 0.969544169809519 -0.0446214697749013 0.873408648545366 1 1.0862 1.03386 0.984253 1.01191 GeneID:10203,Genbank:NM_001271751.1,HGNC:HGNC:16709,MIM:114190 calcitonin receptor like receptor GO:0001525,GO:0001605,GO:0001635,GO:0004930,GO:0004948,GO:0005737,GO:0005764,GO:0005768,GO:0005783,GO:0005886,GO:0005887,GO:0006816,GO:0007166,GO:0007186,GO:0007187,GO:0007189,GO:0007507,GO:0008565,GO:0015031,GO:0031623,GO:0045986,GO:0048661,GO:0050728,GO:0071329,GO:1903143,GO:1990406,GO:1990408,GO:1990409,GO:1990410 angiogenesis|adrenomedullin receptor activity|calcitonin gene-related peptide receptor activity|G-protein coupled receptor activity|calcitonin receptor activity|cytoplasm|lysosome|endosome|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|calcium ion transport|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-activating G-protein coupled receptor signaling pathway|heart development|protein transporter activity|protein transport|receptor internalization|negative regulation of smooth muscle contraction|positive regulation of smooth muscle cell proliferation|negative regulation of inflammatory response|cellular response to sucrose stimulus|adrenomedullin receptor complex|CGRP receptor complex|calcitonin gene-related peptide receptor signaling pathway|adrenomedullin binding|adrenomedullin receptor signaling pathway hsa04080,hsa04270 Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction CALD1 2034.12064602093 2095.51139238803 1972.72989965383 0.941407384765262 -0.0871089247554206 0.780921361064831 1 9.47871 7.75662 9.44535 6.57346 GeneID:800,Genbank:NM_033138.3,HGNC:HGNC:1441,MIM:114213 caldesmon 1 GO:0003779,GO:0005516,GO:0005523,GO:0005829,GO:0005856,GO:0005886,GO:0006928,GO:0006936,GO:0015629,GO:0017022,GO:0030016,GO:0030478,GO:0043231,GO:0045296 actin binding|calmodulin binding|tropomyosin binding|cytosol|cytoskeleton|plasma membrane|movement of cell or subcellular component|muscle contraction|actin cytoskeleton|myosin binding|myofibril|actin cap|intracellular membrane-bounded organelle|cadherin binding hsa04270 Vascular smooth muscle contraction CALHM2 24.8364611864997 23.9938813856949 25.6790409873045 1.07023288873197 0.097924769392461 0.909409319372842 1 0.27014 0.368951 0.203893 0.454691 GeneID:51063,Genbank:XM_017016308.2,HGNC:HGNC:23493,MIM:612235 calcium homeostasis modulator family member 2 GO:0005261,GO:0005887,GO:0034220 cation channel activity|integral component of plasma membrane|ion transmembrane transport CALHM3 1.29134484549723 1.61429302992691 0.968396661067546 0.599889018359566 -0.737232473286342 0.974655394057561 1 0.127454 0 0 0.0725136 GeneID:119395,Genbank:NM_001129742.1,HGNC:HGNC:23458 calcium homeostasis modulator 3 GO:0005261,GO:0005887,GO:0034220 cation channel activity|integral component of plasma membrane|ion transmembrane transport CALHM5 218.295811526097 210.294398366082 226.297224686112 1.07609725434613 0.105808470108619 0.639860256375647 1 0.834752 0.885524 0.849212 1.02438 GeneID:254228,Genbank:NM_153711.3,HGNC:HGNC:21568 calcium homeostasis modulator family member 5 GO:0005261,GO:0005887,GO:0034220,GO:0070062 cation channel activity|integral component of plasma membrane|ion transmembrane transport|extracellular exosome CALHM6 1.74989846105683 1.07619535328461 2.42360156882906 2.25200895119282 1.17121256179462 0.729411591636508 1 0.139444 0 0.192609 0.119298 GeneID:441168,Genbank:NM_001010919.2,HGNC:HGNC:33391,MIM:617305 calcium homeostasis modulator family member 6 GO:0005261,GO:0005887,GO:0034220 cation channel activity|integral component of plasma membrane|ion transmembrane transport CALM1 5162.20841015227 5126.16591925239 5198.25090105216 1.01406216321033 0.020146093964913 0.874656232615739 1 44.5378 44.6913 48.2577 43.5828 GeneID:801,Genbank:NM_006888.4,HGNC:HGNC:1442,MIM:114180 calmodulin 1 GO:0005509 calcium ion binding hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418 Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALM2 8565.03552818236 9331.71363464782 7798.35742171689 0.835683318952511 -0.25897175632731 0.0492494714654222 0.813062736622003 75.6472 76.8816 63.5278 64.3295 GeneID:805,Genbank:NM_001305625.1,HGNC:HGNC:1445,MIM:114182 calmodulin 2 GO:0005509 calcium ion binding hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418 Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALM3 12656.4929221017 11455.7144836386 13857.2713605648 1.2096383320618 0.274575762759619 0.0359303860080999 0.738653561785664 167.294 172.379 220.218 198.718 GeneID:808,Genbank:NM_001329921.1,HGNC:HGNC:1449,MIM:114183 calmodulin 3 GO:0005509 calcium ion binding hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418 Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALML4 168.151290991017 155.503470897082 180.799111084951 1.16266929633108 0.217440802409325 0.473707044163558 1 1.0416 1.06672 1.52929 0.955211 GeneID:91860,Genbank:NM_001286695.1,HGNC:HGNC:18445 calmodulin like 4 GO:0005509 calcium ion binding hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418 Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALML5 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0639966 0 0 GeneID:51806,Genbank:NM_017422.4,HGNC:HGNC:18180,MIM:605183 calmodulin like 5 GO:0005509,GO:0005576,GO:0007165,GO:0008544,GO:0043312,GO:0070062,GO:1904813 calcium ion binding|extracellular region|signal transduction|epidermis development|neutrophil degranulation|extracellular exosome|ficolin-1-rich granule lumen hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418 Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALML6 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0165628 0.0175082 0 GeneID:163688,Genbank:XM_005244729.3,HGNC:HGNC:24193,MIM:610171 calmodulin like 6 GO:0005509,GO:0005634,GO:0005737 calcium ion binding|nucleus|cytoplasm hsa04014,hsa04015,hsa04020,hsa04022,hsa04024,hsa04070,hsa04114,hsa04218,hsa04261,hsa04270,hsa04371,hsa04625,hsa04713,hsa04720,hsa04722,hsa04728,hsa04740,hsa04744,hsa04750,hsa04910,hsa04912,hsa04915,hsa04916,hsa04921,hsa04922,hsa04924,hsa04925,hsa04970,hsa04971,hsa05010,hsa05031,hsa05034,hsa05133,hsa05152,hsa05163,hsa05167,hsa05170,hsa05200,hsa05214,hsa05418 Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Dopaminergic synapse|Olfactory transduction|Phototransduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Salivary secretion|Gastric acid secretion|Alzheimer disease|Amphetamine addiction|Alcoholism|Pertussis|Tuberculosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Glioma|Fluid shear stress and atherosclerosis CALN1 1.26483015846966 1.07619535328461 1.45346496365472 1.35055866875717 0.43355631240266 1 1 0.00604722 0 0.00287199 0.00536417 GeneID:83698,Genbank:XM_017012677.1,HGNC:HGNC:13248,MIM:607176 calneuron 1 GO:0005509,GO:0005886,GO:0016021,GO:0032588,GO:0048471 calcium ion binding|plasma membrane|integral component of membrane|trans-Golgi network membrane|perinuclear region of cytoplasm CALR 37247.4255698859 35802.3507977805 38692.5003419914 1.08072513340074 0.111999641385646 0.391484652896598 1 507.995 540.544 566.53 580.659 GeneID:811,Genbank:NM_004343.3,HGNC:HGNC:1455,MIM:109091 calreticulin hsa04141,hsa04145,hsa04612,hsa05142,hsa05163,hsa05166,hsa05169,hsa05170 Protein processing in endoplasmic reticulum|Phagosome|Antigen processing and presentation|Chagas disease (American trypanosomiasis)|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection CALU 24849.4691300147 25991.3783635725 23707.5598964568 0.912131690933463 -0.132685963325323 0.312035574409236 1 131.164 127.635 113.788 123.993 GeneID:813,Genbank:NM_001199671.1,HGNC:HGNC:1458,MIM:603420 calumenin GO:0005509,GO:0005576,GO:0005789,GO:0005794,GO:0033018,GO:0042470 calcium ion binding|extracellular region|endoplasmic reticulum membrane|Golgi apparatus|sarcoplasmic reticulum lumen|melanosome CALY 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:50632,Genbank:NM_001321617.1,HGNC:HGNC:17938,MIM:604647 calcyon neuron specific vesicular protein GO:0005768,GO:0005887,GO:0006897,GO:0007212,GO:0016197,GO:0030659,GO:0031410,GO:0032051,GO:0032403,GO:0045807,GO:0048268 endosome|integral component of plasma membrane|endocytosis|dopamine receptor signaling pathway|endosomal transport|cytoplasmic vesicle membrane|cytoplasmic vesicle|clathrin light chain binding|protein complex binding|positive regulation of endocytosis|clathrin coat assembly hsa04728 Dopaminergic synapse CAMK1 887.212739865881 906.981431495562 867.4440482362 0.956407725796363 -0.0643023107986317 0.663248431404601 1 13.7599 15.6744 14.0319 13.8867 GeneID:8536,Genbank:XM_017007354.1,HGNC:HGNC:1459,MIM:604998 calcium/calmodulin dependent protein kinase I GO:0004683,GO:0005516,GO:0005524,GO:0005622,GO:0005634,GO:0005737,GO:0006468,GO:0006913,GO:0007049,GO:0007165,GO:0010976,GO:0018107,GO:0032091,GO:0032880,GO:0033138,GO:0035556,GO:0043393,GO:0045944,GO:0046827,GO:0051147,GO:0051149,GO:0051835,GO:0060143,GO:0060999,GO:0071902,GO:1901985 calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|intracellular|nucleus|cytoplasm|protein phosphorylation|nucleocytoplasmic transport|cell cycle|signal transduction|positive regulation of neuron projection development|peptidyl-threonine phosphorylation|negative regulation of protein binding|regulation of protein localization|positive regulation of peptidyl-serine phosphorylation|intracellular signal transduction|regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of protein export from nucleus|regulation of muscle cell differentiation|positive regulation of muscle cell differentiation|positive regulation of synapse structural plasticity|positive regulation of syncytium formation by plasma membrane fusion|positive regulation of dendritic spine development|positive regulation of protein serine/threonine kinase activity|positive regulation of protein acetylation hsa04921,hsa04925 Oxytocin signaling pathway|Aldosterone synthesis and secretion CAMK1D 245.778877189179 268.602069543046 222.955684835312 0.830059445240356 -0.268713435195913 0.210476625195194 1 0.782557 0.802478 0.801025 0.557856 GeneID:57118,Genbank:XM_006717482.3,HGNC:HGNC:19341,MIM:607957 calcium/calmodulin dependent protein kinase ID GO:0004683,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0006954,GO:0010976,GO:0018105,GO:0018107,GO:0032793,GO:0035556,GO:0043065,GO:0043066,GO:0050766,GO:0050773,GO:0060267,GO:0071622,GO:0090023 calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|nucleus|cytoplasm|inflammatory response|positive regulation of neuron projection development|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of CREB transcription factor activity|intracellular signal transduction|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of phagocytosis|regulation of dendrite development|positive regulation of respiratory burst|regulation of granulocyte chemotaxis|positive regulation of neutrophil chemotaxis hsa04921,hsa04925 Oxytocin signaling pathway|Aldosterone synthesis and secretion CAMK1G 3.58815059033175 5.23689794236822 1.93940323829528 0.370334358171252 -1.43309969157326 0.437044225774006 1 0.0788427 0.0283219 0.044254 0 GeneID:57172,Genbank:NM_020439.2,HGNC:HGNC:14585,MIM:614994 calcium/calmodulin dependent protein kinase IG GO:0000139,GO:0004683,GO:0005516,GO:0005524,GO:0005622,GO:0005886,GO:0005954,GO:0018105,GO:0018107,GO:0035556,GO:0043005 Golgi membrane|calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|intracellular|plasma membrane|calcium- and calmodulin-dependent protein kinase complex|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|intracellular signal transduction|neuron projection hsa04921,hsa04925 Oxytocin signaling pathway|Aldosterone synthesis and secretion CAMK2B 2.72036168578278 1.56626675524197 3.87445661632358 2.4736888549518 1.30666404694008 0.556531419407559 1 0.00914593 0.00795798 0 0.03969 GeneID:816,Genbank:NM_172084.2,HGNC:HGNC:1461,MIM:607707 calcium/calmodulin dependent protein kinase II beta GO:0000165,GO:0003779,GO:0004674,GO:0004683,GO:0005088,GO:0005516,GO:0005524,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0010976,GO:0014733,GO:0018105,GO:0018107,GO:0030666,GO:0033017,GO:0035556,GO:0042802,GO:0042803,GO:0043005,GO:0046777,GO:0048169,GO:0051823,GO:0051924,GO:0060333,GO:0060998,GO:0061003,GO:0090129,GO:1900034 MAPK cascade|actin binding|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|Ras guanyl-nucleotide exchange factor activity|calmodulin binding|ATP binding|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|plasma membrane|protein phosphorylation|signal transduction|positive regulation of neuron projection development|regulation of skeletal muscle adaptation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|endocytic vesicle membrane|sarcoplasmic reticulum membrane|intracellular signal transduction|identical protein binding|protein homodimerization activity|neuron projection|protein autophosphorylation|regulation of long-term neuronal synaptic plasticity|regulation of synapse structural plasticity|regulation of calcium ion transport|interferon-gamma-mediated signaling pathway|regulation of dendritic spine development|positive regulation of dendritic spine morphogenesis|positive regulation of synapse maturation|regulation of cellular response to heat hsa04012,hsa04020,hsa04024,hsa04066,hsa04114,hsa04217,hsa04261,hsa04310,hsa04360,hsa04713,hsa04720,hsa04722,hsa04725,hsa04728,hsa04740,hsa04750,hsa04911,hsa04912,hsa04916,hsa04921,hsa04922,hsa04925,hsa04934,hsa04971,hsa05031,hsa05152,hsa05200,hsa05205,hsa05214 ErbB signaling pathway|Calcium signaling pathway|cAMP signaling pathway|HIF-1 signaling pathway|Oocyte meiosis|Necroptosis|Adrenergic signaling in cardiomyocytes|Wnt signaling pathway|Axon guidance|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Aldosterone synthesis and secretion|Cushing syndrome|Gastric acid secretion|Amphetamine addiction|Tuberculosis|Pathways in cancer|Proteoglycans in cancer|Glioma CAMK2D 1281.86631126993 1229.39225170198 1334.34037083787 1.08536585373024 0.118181426443627 0.537789360120385 1 5.96595 5.49896 7.46935 5.28605 GeneID:817,Genbank:NM_001321578.1,HGNC:HGNC:1462,MIM:607708 calcium/calmodulin dependent protein kinase II delta GO:0000082,GO:0002028,GO:0003254,GO:0004674,GO:0004683,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0006816,GO:0007399,GO:0010613,GO:0014704,GO:0016529,GO:0018105,GO:0018107,GO:0019871,GO:0030154,GO:0030315,GO:0031432,GO:0031594,GO:0033017,GO:0035556,GO:0042802,GO:0042803,GO:0043025,GO:0043194,GO:0044325,GO:0046777,GO:0051259,GO:0055119,GO:0060048,GO:0060341,GO:0086003,GO:1901897,GO:1902306,GO:2000650 G1/S transition of mitotic cell cycle|regulation of sodium ion transport|regulation of membrane depolarization|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|nucleus|cytoplasm|protein phosphorylation|calcium ion transport|nervous system development|positive regulation of cardiac muscle hypertrophy|intercalated disc|sarcoplasmic reticulum|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sodium channel inhibitor activity|cell differentiation|T-tubule|titin binding|neuromuscular junction|sarcoplasmic reticulum membrane|intracellular signal transduction|identical protein binding|protein homodimerization activity|neuronal cell body|axon initial segment|ion channel binding|protein autophosphorylation|protein oligomerization|relaxation of cardiac muscle|cardiac muscle contraction|regulation of cellular localization|cardiac muscle cell contraction|regulation of relaxation of cardiac muscle|negative regulation of sodium ion transmembrane transport|negative regulation of sodium ion transmembrane transporter activity hsa04012,hsa04020,hsa04024,hsa04066,hsa04114,hsa04217,hsa04261,hsa04310,hsa04360,hsa04713,hsa04720,hsa04722,hsa04725,hsa04728,hsa04740,hsa04750,hsa04911,hsa04912,hsa04916,hsa04921,hsa04922,hsa04925,hsa04934,hsa04971,hsa05031,hsa05152,hsa05200,hsa05205,hsa05214 ErbB signaling pathway|Calcium signaling pathway|cAMP signaling pathway|HIF-1 signaling pathway|Oocyte meiosis|Necroptosis|Adrenergic signaling in cardiomyocytes|Wnt signaling pathway|Axon guidance|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Aldosterone synthesis and secretion|Cushing syndrome|Gastric acid secretion|Amphetamine addiction|Tuberculosis|Pathways in cancer|Proteoglycans in cancer|Glioma CAMK2G 1395.97723495826 1324.94636642856 1467.00810348796 1.1072207454271 0.14694287937739 0.318570480708543 1 8.18892 7.98344 9.48529 8.66818 GeneID:818,Genbank:NM_001222.3,HGNC:HGNC:1463,MIM:602123 calcium/calmodulin dependent protein kinase II gamma GO:0000082,GO:0004674,GO:0004683,GO:0005516,GO:0005524,GO:0005737,GO:0006816,GO:0007399,GO:0014069,GO:0018105,GO:0018107,GO:0030154,GO:0033017,GO:0035556,GO:0042802,GO:0042803,GO:0043005,GO:0046777,GO:0051259,GO:1901897 G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|cytoplasm|calcium ion transport|nervous system development|postsynaptic density|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cell differentiation|sarcoplasmic reticulum membrane|intracellular signal transduction|identical protein binding|protein homodimerization activity|neuron projection|protein autophosphorylation|protein oligomerization|regulation of relaxation of cardiac muscle hsa04012,hsa04020,hsa04024,hsa04066,hsa04114,hsa04217,hsa04261,hsa04310,hsa04360,hsa04713,hsa04720,hsa04722,hsa04725,hsa04728,hsa04740,hsa04750,hsa04911,hsa04912,hsa04916,hsa04921,hsa04922,hsa04925,hsa04934,hsa04971,hsa05031,hsa05152,hsa05200,hsa05205,hsa05214 ErbB signaling pathway|Calcium signaling pathway|cAMP signaling pathway|HIF-1 signaling pathway|Oocyte meiosis|Necroptosis|Adrenergic signaling in cardiomyocytes|Wnt signaling pathway|Axon guidance|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Dopaminergic synapse|Olfactory transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Oxytocin signaling pathway|Glucagon signaling pathway|Aldosterone synthesis and secretion|Cushing syndrome|Gastric acid secretion|Amphetamine addiction|Tuberculosis|Pathways in cancer|Proteoglycans in cancer|Glioma CAMK2N1 475.052774857394 385.958440328317 564.147109386471 1.46167838409383 0.547625907243933 0.00223105626573646 0.170155224533501 8.26256 10.2677 15.1565 12.4999 GeneID:55450,Genbank:NM_018584.5,HGNC:HGNC:24190,MIM:614986 calcium/calmodulin dependent protein kinase II inhibitor 1 GO:0005622,GO:0006469,GO:0008285,GO:0008427,GO:0010628,GO:0014069,GO:0019901,GO:0030054,GO:0030425,GO:0043025,GO:0045211,GO:0045786,GO:0045861,GO:0070373,GO:1904030 intracellular|negative regulation of protein kinase activity|negative regulation of cell proliferation|calcium-dependent protein kinase inhibitor activity|positive regulation of gene expression|postsynaptic density|protein kinase binding|cell junction|dendrite|neuronal cell body|postsynaptic membrane|negative regulation of cell cycle|negative regulation of proteolysis|negative regulation of ERK1 and ERK2 cascade|negative regulation of cyclin-dependent protein kinase activity CAMK2N2 283.369392527095 301.676984847614 265.061800206575 0.87862784872524 -0.186675867501908 0.374672343732251 1 11.6363 12.67 9.68564 11.8001 GeneID:94032,Genbank:NM_033259.2,HGNC:HGNC:24197,MIM:608721 calcium/calmodulin dependent protein kinase II inhibitor 2 GO:0005634,GO:0005813,GO:0005829,GO:0008427,GO:0019901 nucleus|centrosome|cytosol|calcium-dependent protein kinase inhibitor activity|protein kinase binding CAMK4 258.058254931972 269.380298593113 246.736211270831 0.915940076388123 -0.126674879016657 0.743739133140406 1 0.928387 0.946532 1.10718 0.612839 GeneID:814,Genbank:NM_001323375.1,HGNC:HGNC:1464,MIM:114080 calcium/calmodulin dependent protein kinase IV GO:0001650,GO:0002250,GO:0004683,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006954,GO:0007165,GO:0007616,GO:0009931,GO:0018105,GO:0033081,GO:0035556,GO:0043011,GO:0045670,GO:0045893,GO:0046777,GO:0070062 fibrillar center|adaptive immune response|calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|inflammatory response|signal transduction|long-term memory|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|regulation of T cell differentiation in thymus|intracellular signal transduction|myeloid dendritic cell differentiation|regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|protein autophosphorylation|extracellular exosome hsa04020,hsa04024,hsa04211,hsa04371,hsa04380,hsa04720,hsa04722,hsa04725,hsa04921,hsa04925,hsa05031,hsa05034 Calcium signaling pathway|cAMP signaling pathway|Longevity regulating pathway|Apelin signaling pathway|Osteoclast differentiation|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Amphetamine addiction|Alcoholism CAMKK1 58.3344134420067 60.4600618835326 56.2087650004807 0.929684212178919 -0.105187338762974 0.824225553446527 1 0.257527 0.166756 0.180571 0.272584 GeneID:84254,Genbank:XM_006721588.3,HGNC:HGNC:1469,MIM:611411 calcium/calmodulin dependent protein kinase kinase 1 GO:0004683,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0018105,GO:0018107,GO:0035556,GO:0045860 calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|intracellular signal transduction|positive regulation of protein kinase activity hsa05034 Alcoholism CAMKK2 706.574458928557 705.565136293651 707.583781563463 1.00286103318599 0.00412170502931517 0.993006549424941 1 3.8885 4.25772 4.55501 3.85669 GeneID:10645,Genbank:NM_153500.1,HGNC:HGNC:1470,MIM:615002 calcium/calmodulin dependent protein kinase kinase 2 GO:0000165,GO:0001934,GO:0004683,GO:0004713,GO:0005509,GO:0005516,GO:0005524,GO:0005622,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0018105,GO:0018107,GO:0019722,GO:0034614,GO:0042995,GO:0045859,GO:0045860,GO:0045893,GO:0046777,GO:0061762,GO:1903599 MAPK cascade|positive regulation of protein phosphorylation|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity|calcium ion binding|calmodulin binding|ATP binding|intracellular|nucleus|cytoplasm|cytosol|protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|calcium-mediated signaling|cellular response to reactive oxygen species|cell projection|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of transcription, DNA-templated|protein autophosphorylation|CAMKK-AMPK signaling cascade|positive regulation of autophagy of mitochondrion hsa04140,hsa04152,hsa04211,hsa04920,hsa04921,hsa05034 Autophagy - animal|AMPK signaling pathway|Longevity regulating pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Alcoholism CAMKMT 83.0970319076044 91.5648829251632 74.6291808900456 0.815041514889947 -0.295054548671914 0.358431294175145 1 0.15271 0.194665 0.126378 0.147601 GeneID:79823,Genbank:XM_017004971.1,HGNC:HGNC:26276,MIM:609559 calmodulin-lysine N-methyltransferase GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0006479,GO:0007005,GO:0018025,GO:0022400,GO:0031072,GO:0043234 nucleus|cytoplasm|Golgi apparatus|cytosol|protein methylation|mitochondrion organization|calmodulin-lysine N-methyltransferase activity|regulation of rhodopsin mediated signaling pathway|heat shock protein binding|protein complex hsa00310 Lysine degradation CAMKV 3.21423959550533 3.03648096111406 3.3919982298966 1.11708200161153 0.159735093588509 1 1 0.0277897 0.0368115 0.0259601 0.0363953 GeneID:79012,Genbank:NM_001320147.1,HGNC:HGNC:28788,MIM:614993 CaM kinase like vesicle associated GO:0004683,GO:0005516,GO:0005524,GO:0005622,GO:0005886,GO:0018105,GO:0018107,GO:0030659,GO:0035556 calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|intracellular|plasma membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cytoplasmic vesicle membrane|intracellular signal transduction CAMLG 690.39576492605 701.365199084135 679.426330767966 0.968719764903052 -0.0458487174377877 0.794136050252656 1 13.7694 13.0247 13.1814 13.3339 GeneID:819,Genbank:NM_001745.3,HGNC:HGNC:1471,MIM:601118 calcium modulating ligand GO:0001881,GO:0005783,GO:0006952,GO:0007165,GO:0007173,GO:0016020,GO:0016021,GO:0016032 receptor recycling|endoplasmic reticulum|defense response|signal transduction|epidermal growth factor receptor signaling pathway|membrane|integral component of membrane|viral process CAMP 1.21386734807293 0.490071401957362 1.93766329418849 3.95383873951713 1.98325403079315 0.683591311517638 1 0 0.0552023 0.0583174 0.162093 GeneID:820,Genbank:NM_004345.4,HGNC:HGNC:1472,MIM:600474 cathelicidin antimicrobial peptide GO:0001878,GO:0002227,GO:0002544,GO:0005576,GO:0005615,GO:0005622,GO:0019730,GO:0019731,GO:0019732,GO:0035580,GO:0035821,GO:0042581,GO:0042742,GO:0043312,GO:0044140,GO:0045087,GO:0050829,GO:0050830,GO:0051838,GO:0051873,GO:0061844,GO:0070062,GO:1904724,GO:2000484 response to yeast|innate immune response in mucosa|chronic inflammatory response|extracellular region|extracellular space|intracellular|antimicrobial humoral response|antibacterial humoral response|antifungal humoral response|specific granule lumen|modification of morphology or physiology of other organism|specific granule|defense response to bacterium|neutrophil degranulation|negative regulation of growth of symbiont on or near host surface|innate immune response|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|cytolysis by host of symbiont cells|killing by host of symbiont cells|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome|tertiary granule lumen|positive regulation of interleukin-8 secretion hsa04621,hsa04970,hsa05152 NOD-like receptor signaling pathway|Salivary secretion|Tuberculosis CAMSAP1 1826.39270201238 1807.75461389909 1845.03079012566 1.02062015272425 0.0294460339488405 0.851055998978466 1 7.49176 7.82347 8.24078 7.51453 GeneID:157922,Genbank:XM_005263396.3,HGNC:HGNC:19946,MIM:613774 calmodulin regulated spectrin associated protein 1 GO:0000226,GO:0005516,GO:0005737,GO:0005874,GO:0007010,GO:0008017,GO:0022604,GO:0030507,GO:0031113,GO:0031175,GO:0051011 microtubule cytoskeleton organization|calmodulin binding|cytoplasm|microtubule|cytoskeleton organization|microtubule binding|regulation of cell morphogenesis|spectrin binding|regulation of microtubule polymerization|neuron projection development|microtubule minus-end binding CAMSAP2 498.169997378947 539.739722989285 456.60027176861 0.845963808703541 -0.24133215036102 0.495331940818093 1 2.64963 2.10371 2.47031 1.55968 GeneID:23271,Genbank:XM_017000799.1,HGNC:HGNC:29188,MIM:613775 calmodulin regulated spectrin associated protein family member 2 GO:0000226,GO:0005516,GO:0005794,GO:0005829,GO:0030507,GO:0031113,GO:0033043,GO:0050773,GO:0051011,GO:0061564,GO:1903358,GO:1990752 microtubule cytoskeleton organization|calmodulin binding|Golgi apparatus|cytosol|spectrin binding|regulation of microtubule polymerization|regulation of organelle organization|regulation of dendrite development|microtubule minus-end binding|axon development|regulation of Golgi organization|microtubule end CAMSAP3 8.14090092862473 8.52331893201493 7.75848292523453 0.910265471363796 -0.135640738184738 0.943647224118614 1 0.0512864 0.12823 0.139983 0.0328636 GeneID:57662,Genbank:NM_001080429.2,HGNC:HGNC:29307,MIM:612685 calmodulin regulated spectrin associated protein family member 3 GO:0000226,GO:0005516,GO:0005737,GO:0005874,GO:0005915,GO:0009792,GO:0010923,GO:0030334,GO:0030507,GO:0030951,GO:0031113,GO:0031175,GO:0033043,GO:0034453,GO:0045198,GO:0045218,GO:0051011,GO:0051015,GO:0051893,GO:0070507,GO:0090136,GO:0098840,GO:1903358 microtubule cytoskeleton organization|calmodulin binding|cytoplasm|microtubule|zonula adherens|embryo development ending in birth or egg hatching|negative regulation of phosphatase activity|regulation of cell migration|spectrin binding|establishment or maintenance of microtubule cytoskeleton polarity|regulation of microtubule polymerization|neuron projection development|regulation of organelle organization|microtubule anchoring|establishment of epithelial cell apical/basal polarity|zonula adherens maintenance|microtubule minus-end binding|actin filament binding|regulation of focal adhesion assembly|regulation of microtubule cytoskeleton organization|epithelial cell-cell adhesion|protein transport along microtubule|regulation of Golgi organization CAMTA1 851.507862952937 852.516879294249 850.498846611625 0.997632853106329 -0.00341911946200803 0.973205634519008 1 0.753776 0.707569 0.726631 0.732216 GeneID:23261,Genbank:NM_015215.3,HGNC:HGNC:18806,MIM:611501 calmodulin binding transcription activator 1 GO:0001077,GO:0005634,GO:0005730,GO:0005829,GO:0043565,GO:0045944,GO:0050885 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|nucleolus|cytosol|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|neuromuscular process controlling balance CAMTA2 1422.96236558242 1429.83922975594 1416.0855014089 0.990380926707827 -0.0139445642699563 0.915897075825992 1 8.69487 8.90327 9.19461 8.67952 GeneID:23125,Genbank:NM_001171166.1,HGNC:HGNC:18807,MIM:611508 calmodulin binding transcription activator 2 GO:0001077,GO:0003682,GO:0005634,GO:0006357,GO:0008134,GO:0014898,GO:0042826,GO:0043565,GO:0045944 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|chromatin binding|nucleus|regulation of transcription from RNA polymerase II promoter|transcription factor binding|cardiac muscle hypertrophy in response to stress|histone deacetylase binding|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter CAND1 1024.11427810543 1086.14834050723 962.080215703635 0.88577239390187 -0.174992060185576 0.502898301609341 1 8.45868 6.53153 7.5482 5.72899 GeneID:55832,Genbank:NM_001329674.1,HGNC:HGNC:30688,MIM:607727 cullin associated and neddylation dissociated 1 GO:0000151,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006879,GO:0010265,GO:0016020,GO:0016567,GO:0017025,GO:0030154,GO:0031461,GO:0034774,GO:0043086,GO:0043312,GO:0043687,GO:0045899,GO:0070062,GO:1904813 ubiquitin ligase complex|extracellular region|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|cellular iron ion homeostasis|SCF complex assembly|membrane|protein ubiquitination|TBP-class protein binding|cell differentiation|cullin-RING ubiquitin ligase complex|secretory granule lumen|negative regulation of catalytic activity|neutrophil degranulation|post-translational protein modification|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|extracellular exosome|ficolin-1-rich granule lumen CAND2 178.354891633117 160.942282593298 195.767500672935 1.21638327429244 0.282597884041979 0.23779079380788 1 1.37039 1.28764 1.41486 1.86887 GeneID:23066,Genbank:XM_011533503.2,HGNC:HGNC:30689,MIM:610403 cullin associated and neddylation dissociated 2 (putative) GO:0005622,GO:0005634,GO:0006351,GO:0010265,GO:0016567,GO:0017025,GO:0045893 intracellular|nucleus|transcription, DNA-templated|SCF complex assembly|protein ubiquitination|TBP-class protein binding|positive regulation of transcription, DNA-templated CANT1 2938.00142538414 2716.26409453032 3159.73875623795 1.16326640056858 0.218181527393596 0.115469458233164 1 25.2054 27.3534 31.1479 30.594 GeneID:124583,Genbank:NM_001159773.1,HGNC:HGNC:19721,MIM:613165 calcium activated nucleotidase 1 GO:0004382,GO:0004871,GO:0005509,GO:0005576,GO:0005789,GO:0005886,GO:0016020,GO:0016021,GO:0030166,GO:0032580,GO:0035580,GO:0042803,GO:0043123,GO:0043262,GO:0043312,GO:0045134,GO:0070062,GO:1904724,GO:1904813 guanosine-diphosphatase activity|signal transducer activity|calcium ion binding|extracellular region|endoplasmic reticulum membrane|plasma membrane|membrane|integral component of membrane|proteoglycan biosynthetic process|Golgi cisterna membrane|specific granule lumen|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|adenosine-diphosphatase activity|neutrophil degranulation|uridine-diphosphatase activity|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen hsa00230,hsa00240 Purine metabolism|Pyrimidine metabolism CANX 23574.4840991685 24953.9604869163 22195.0077114208 0.889438280671237 -0.169033596487496 0.197494299819687 1 155.562 146.501 144.917 125.56 GeneID:821,Genbank:XM_011534665.3,HGNC:HGNC:1473,MIM:114217 calnexin hsa04141,hsa04145,hsa04612,hsa04918,hsa05166 Protein processing in endoplasmic reticulum|Phagosome|Antigen processing and presentation|Thyroid hormone synthesis|Human T-cell leukemia virus 1 infection CAP1 10313.8894549065 10336.3772306155 10291.4016791975 0.995648809015527 -0.00629113857541221 0.957666037843505 1 111.231 113.01 113.895 112.095 GeneID:10487,Genbank:NM_001350479.1,HGNC:HGNC:20040,MIM:617801 cyclase associated actin cytoskeleton regulatory protein 1 GO:0000902,GO:0001667,GO:0003779,GO:0005576,GO:0005886,GO:0005925,GO:0006898,GO:0007163,GO:0007165,GO:0007190,GO:0008154,GO:0008179,GO:0030864,GO:0035578,GO:0043312,GO:0070062 cell morphogenesis|ameboidal-type cell migration|actin binding|extracellular region|plasma membrane|focal adhesion|receptor-mediated endocytosis|establishment or maintenance of cell polarity|signal transduction|activation of adenylate cyclase activity|actin polymerization or depolymerization|adenylate cyclase binding|cortical actin cytoskeleton|azurophil granule lumen|neutrophil degranulation|extracellular exosome CAP2 1078.51750590805 1146.54279280758 1010.49221900853 0.881338424825914 -0.182231989401408 0.238234582358895 1 13.0702 11.9378 12.0209 10.4418 GeneID:10486,Genbank:XM_011514233.2,HGNC:HGNC:20039 cyclase associated actin cytoskeleton regulatory protein 2 GO:0000902,GO:0003779,GO:0005886,GO:0007163,GO:0007165,GO:0007190,GO:0008154,GO:0008179,GO:0014069,GO:0030864,GO:0042802 cell morphogenesis|actin binding|plasma membrane|establishment or maintenance of cell polarity|signal transduction|activation of adenylate cyclase activity|actin polymerization or depolymerization|adenylate cyclase binding|postsynaptic density|cortical actin cytoskeleton|identical protein binding CAPG 20.8810471845382 22.8696597577253 18.8924346113511 0.826091634571402 -0.275626272795605 0.723403769942434 1 0.273711 0.406959 0.137678 0.366537 GeneID:822,Genbank:NM_001256139.1,HGNC:HGNC:1474,MIM:153615 capping actin protein, gelsolin like CAPN1 3055.10414011537 2966.03172839003 3144.1765518407 1.06006167154097 0.0841481993527818 0.546734946588383 1 31.5184 31.1824 34.2315 34.4365 GeneID:823,Genbank:NM_001198868.1,HGNC:HGNC:1476,MIM:114220 calpain 1 hsa04141,hsa04210,hsa04217,hsa04218,hsa05010 Protein processing in endoplasmic reticulum|Apoptosis|Necroptosis|Cellular senescence|Alzheimer disease CAPN10 402.387524640228 387.514898428451 417.260150852005 1.07675899054252 0.106695369604341 0.584717725285713 1 6.80311 7.32422 7.84572 8.05876 GeneID:11132,Genbank:NM_023083.3,HGNC:HGNC:1477,MIM:605286 calpain 10 GO:0000149,GO:0004198,GO:0005739,GO:0005829,GO:0005886,GO:0006508,GO:0006921,GO:0008092,GO:0031532,GO:0032024,GO:0032388,GO:0032869,GO:0046326,GO:0097050,GO:2000676 SNARE binding|calcium-dependent cysteine-type endopeptidase activity|mitochondrion|cytosol|plasma membrane|proteolysis|cellular component disassembly involved in execution phase of apoptosis|cytoskeletal protein binding|actin cytoskeleton reorganization|positive regulation of insulin secretion|positive regulation of intracellular transport|cellular response to insulin stimulus|positive regulation of glucose import|type B pancreatic cell apoptotic process|positive regulation of type B pancreatic cell apoptotic process CAPN12 169.07317264595 198.618928613367 139.527416678532 0.702488013869701 -0.509454485181223 0.317202721098731 1 1.44063 1.08565 0.645085 1.40079 GeneID:147968,Genbank:NM_144691.4,HGNC:HGNC:13249,MIM:608839 calpain 12 GO:0004198,GO:0005509,GO:0005737,GO:0006508 calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|cytoplasm|proteolysis CAPN14 0.971768182806039 0.490071401957362 1.45346496365472 2.96582285326082 1.56843242909583 0.837471602739444 1 0 0.00844784 0.00866876 0.0161686 GeneID:440854,Genbank:XM_011532864.3,HGNC:HGNC:16664,MIM:610229 calpain 14 GO:0004198,GO:0005509,GO:0005737,GO:0006508 calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|cytoplasm|proteolysis CAPN15 1181.41964291083 1233.62364887853 1129.21563694313 0.915364777555682 -0.12758131553716 0.378028438348826 1 5.86753 6.52957 6.20035 5.68414 GeneID:6650,Genbank:XM_011522628.3,HGNC:HGNC:11182,MIM:603267 calpain 15 GO:0003700,GO:0004198,GO:0005737,GO:0008233,GO:0008234,GO:0046872 DNA binding transcription factor activity|calcium-dependent cysteine-type endopeptidase activity|cytoplasm|peptidase activity|cysteine-type peptidase activity|metal ion binding CAPN2 9826.73024599242 9578.96362926628 10074.4968627186 1.05173140358716 0.0727663090125479 0.584325089892844 1 88.1376 92.0107 104.328 88.6659 GeneID:824,Genbank:NM_001146068.1,HGNC:HGNC:1479,MIM:114230 calpain 2 hsa04141,hsa04210,hsa04217,hsa04218,hsa04510,hsa05010 Protein processing in endoplasmic reticulum|Apoptosis|Necroptosis|Cellular senescence|Focal adhesion|Alzheimer disease CAPN3 33.4273003556451 26.1462720922641 40.7083286190262 1.55694580379857 0.638718726079205 0.198123174847828 1 0.173483 0.147431 0.240256 0.322368 GeneID:825,Genbank:NM_000070.2,HGNC:HGNC:1480,MIM:114240 calpain 3 GO:0003824,GO:0004198,GO:0005102,GO:0005509,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006461,GO:0006508,GO:0008233,GO:0008307,GO:0012501,GO:0014718,GO:0014850,GO:0019899,GO:0030016,GO:0030018,GO:0030239,GO:0030315,GO:0031402,GO:0031432,GO:0032947,GO:0033234,GO:0042493,GO:0043066,GO:0043122,GO:0043234,GO:0045214,GO:0045661,GO:0045862,GO:0045892,GO:0045893,GO:0050790,GO:0051092,GO:0051281,GO:0051592,GO:0055103,GO:0061061,GO:0070315,GO:0071277,GO:0071472,GO:0072657,GO:0097264,GO:1990091,GO:2001015 catalytic activity|calcium-dependent cysteine-type endopeptidase activity|receptor binding|calcium ion binding|nucleus|cytoplasm|cytosol|plasma membrane|protein complex assembly|proteolysis|peptidase activity|structural constituent of muscle|programmed cell death|positive regulation of satellite cell activation involved in skeletal muscle regeneration|response to muscle activity|enzyme binding|myofibril|Z disc|myofibril assembly|T-tubule|sodium ion binding|titin binding|protein complex scaffold activity|negative regulation of protein sumoylation|response to drug|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|protein complex|sarcomere organization|regulation of myoblast differentiation|positive regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of catalytic activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of release of sequestered calcium ion into cytosol|response to calcium ion|ligase regulator activity|muscle structure development|G1 to G0 transition involved in cell differentiation|cellular response to calcium ion|cellular response to salt stress|protein localization to membrane|self proteolysis|sodium-dependent self proteolysis|negative regulation of skeletal muscle cell differentiation CAPN5 312.447548200441 314.255145164234 310.639951236648 0.988495991288554 -0.0166929795751152 0.928173829171649 1 2.54626 2.45793 2.45128 2.57108 GeneID:726,Genbank:NM_004055.4,HGNC:HGNC:1482,MIM:602537 calpain 5 GO:0004198,GO:0005737,GO:0005925,GO:0006508,GO:0007165,GO:0009986,GO:0070062 calcium-dependent cysteine-type endopeptidase activity|cytoplasm|focal adhesion|proteolysis|signal transduction|cell surface|extracellular exosome CAPN6 4.21045590168054 3.57457863775636 4.84633316560471 1.35577746546558 0.439120396899037 0.847047916343533 1 0.0291522 0.0266202 0.0459249 0.042814 GeneID:827,Genbank:NM_014289.3,HGNC:HGNC:1483,MIM:300146 calpain 6 CAPN7 773.997710281786 788.538039701043 759.457380862528 0.963120791421121 -0.054211347435559 0.760694536124461 1 6.07434 5.7689 6.18472 5.09083 GeneID:23473,Genbank:NM_014296.2,HGNC:HGNC:1484,MIM:606400 calpain 7 GO:0004175,GO:0004198,GO:0005634,GO:0005737,GO:0010634,GO:0070062,GO:0090541,GO:0097264 endopeptidase activity|calcium-dependent cysteine-type endopeptidase activity|nucleus|cytoplasm|positive regulation of epithelial cell migration|extracellular exosome|MIT domain binding|self proteolysis CAPN8 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0107218 0 0.0101634 0 GeneID:388743,Genbank:NM_001143962.1,HGNC:HGNC:1485 calpain 8 GO:0004198,GO:0005509,GO:0005737,GO:0005794,GO:0006508,GO:0007586 calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|cytoplasm|Golgi apparatus|proteolysis|digestion CAPN9 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.00795609 0 GeneID:10753,Genbank:XM_011544019.2,HGNC:HGNC:1486,MIM:606401 calpain 9 CAPNS1 12576.5346140788 11949.4571724305 13203.6120557272 1.10495496700806 0.143987573057388 0.274855405264369 1 143.496 149.506 162.676 170.181 GeneID:826,Genbank:NM_001749.3,HGNC:HGNC:1481,MIM:114170 calpain small subunit 1 CAPNS2 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0.0435082 0.0443016 0 GeneID:84290,Genbank:NM_032330.2,HGNC:HGNC:16371,MIM:616767 calpain small subunit 2 CAPRIN1 6971.75824996705 7055.16870483451 6888.3477950996 0.976354795085113 -0.0345225945412049 0.819972988554822 1 41.0104 37.645 41.5742 35.9337 GeneID:4076,Genbank:NM_005898.4,HGNC:HGNC:6743,MIM:601178 cell cycle associated protein 1 GO:0000932,GO:0003723,GO:0005829,GO:0005887,GO:0010494,GO:0016020,GO:0017148,GO:0030425,GO:0050775,GO:0061003 P-body|RNA binding|cytosol|integral component of plasma membrane|cytoplasmic stress granule|membrane|negative regulation of translation|dendrite|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis CAPRIN2 356.679546672684 421.116068752844 292.243024592525 0.693972627209446 -0.527049336072303 0.0560972523379497 0.858942249947038 2.43085 1.80753 1.66804 1.41201 GeneID:65981,Genbank:XM_017019871.2,HGNC:HGNC:21259,MIM:610375 caprin family member 2 GO:0003723,GO:0005102,GO:0005634,GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005886,GO:0017148,GO:0030308,GO:0032092,GO:0033138,GO:0043235,GO:0045944,GO:0046872,GO:0050775,GO:0061003,GO:0090263 RNA binding|receptor binding|nucleus|cytoplasm|mitochondrion|centrosome|cytosol|plasma membrane|negative regulation of translation|negative regulation of cell growth|positive regulation of protein binding|positive regulation of peptidyl-serine phosphorylation|receptor complex|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of canonical Wnt signaling pathway CAPS 15617.8550193964 12273.8983171848 18961.8117216081 1.54488909974588 0.627503277618861 0.0173295581803918 0.545285272725254 222.762 248.644 332.53 410.059 GeneID:828,Genbank:NM_004058.4,HGNC:HGNC:1487,MIM:114212 calcyphosine GO:0005509,GO:0005737,GO:0031982,GO:0035556,GO:0070062 calcium ion binding|cytoplasm|vesicle|intracellular signal transduction|extracellular exosome CAPS2 22.45326176204 22.6099110740847 22.2966124499953 0.986143305780245 -0.0201307814326358 1 1 0.160277 0.0300788 0.155849 0.0551456 GeneID:84698,Genbank:NM_001355026.1,HGNC:HGNC:16471,MIM:607724 calcyphosine 2 GO:0005432,GO:0005509,GO:0055074 calcium:sodium antiporter activity|calcium ion binding|calcium ion homeostasis CAPSL 2.32038389615029 3.67063118712625 0.97013660517434 0.264296943963434 -1.91976835153591 0.448082214481966 1 0.0319905 0 0.0306148 0 GeneID:133690,Genbank:NM_144647.3,HGNC:HGNC:28375 calcyphosine like GO:0005509,GO:0005737 calcium ion binding|cytoplasm CAPZA1 2642.88585815187 3123.77855753878 2161.99315876496 0.692108329365187 -0.530930227536526 0.000131801579112131 0.0274147284553233 39.9977 36.2407 28.0099 25.4716 GeneID:829,Genbank:NM_006135.2,HGNC:HGNC:1488,MIM:601580 capping actin protein of muscle Z-line alpha subunit 1 GO:0003779,GO:0005576,GO:0005829,GO:0005856,GO:0006461,GO:0006888,GO:0006928,GO:0007596,GO:0008290,GO:0015629,GO:0019886,GO:0034329,GO:0035722,GO:0045087,GO:0045296,GO:0051016,GO:0070062,GO:0071203 actin binding|extracellular region|cytosol|cytoskeleton|protein complex assembly|ER to Golgi vesicle-mediated transport|movement of cell or subcellular component|blood coagulation|F-actin capping protein complex|actin cytoskeleton|antigen processing and presentation of exogenous peptide antigen via MHC class II|cell junction assembly|interleukin-12-mediated signaling pathway|innate immune response|cadherin binding|barbed-end actin filament capping|extracellular exosome|WASH complex hsa04144 Endocytosis CAPZA2 1938.93081663105 2142.80041235107 1735.06122091103 0.809716673055575 -0.304510910202073 0.0326327066029987 0.714141733165715 43.6419 42.8561 38.0897 32.2456 GeneID:830,Genbank:NM_006136.2,HGNC:HGNC:1490,MIM:601571 capping actin protein of muscle Z-line alpha subunit 2 GO:0003779,GO:0005576,GO:0005829,GO:0005903,GO:0006461,GO:0006888,GO:0006928,GO:0007596,GO:0008290,GO:0015629,GO:0016020,GO:0019886,GO:0030863,GO:0045087,GO:0051016,GO:0070062 actin binding|extracellular region|cytosol|brush border|protein complex assembly|ER to Golgi vesicle-mediated transport|movement of cell or subcellular component|blood coagulation|F-actin capping protein complex|actin cytoskeleton|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|cortical cytoskeleton|innate immune response|barbed-end actin filament capping|extracellular exosome hsa04144 Endocytosis CAPZB 5071.59870745743 4974.84887025974 5168.34854465511 1.0388955884775 0.0550506671824432 0.700295574806579 1 24.0893 25.7222 25.1575 27.5385 GeneID:832,Genbank:NM_004930.4,HGNC:HGNC:1491,MIM:601572 capping actin protein of muscle Z-line beta subunit GO:0003779,GO:0005829,GO:0005856,GO:0005884,GO:0006888,GO:0006928,GO:0007010,GO:0007596,GO:0008290,GO:0010591,GO:0015629,GO:0019886,GO:0022604,GO:0030017,GO:0030036,GO:0045296,GO:0051015,GO:0051016,GO:0051490,GO:0070062,GO:0071203 actin binding|cytosol|cytoskeleton|actin filament|ER to Golgi vesicle-mediated transport|movement of cell or subcellular component|cytoskeleton organization|blood coagulation|F-actin capping protein complex|regulation of lamellipodium assembly|actin cytoskeleton|antigen processing and presentation of exogenous peptide antigen via MHC class II|regulation of cell morphogenesis|sarcomere|actin cytoskeleton organization|cadherin binding|actin filament binding|barbed-end actin filament capping|negative regulation of filopodium assembly|extracellular exosome|WASH complex hsa04144 Endocytosis CARD10 476.942622325161 446.476337141643 507.40890750868 1.13647435552157 0.184565130192477 0.313135302169745 1 4.44203 5.03211 5.62691 5.38822 GeneID:29775,Genbank:NM_014550.3,HGNC:HGNC:16422,MIM:607209 caspase recruitment domain family member 10 GO:0005737,GO:0006461,GO:0007250,GO:0030159,GO:0032449,GO:0042981 cytoplasm|protein complex assembly|activation of NF-kappaB-inducing kinase activity|receptor signaling complex scaffold activity|CBM complex|regulation of apoptotic process hsa04064 NF-kappa B signaling pathway CARD11 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0.00751982 0 GeneID:84433,Genbank:NM_032415.5,HGNC:HGNC:16393,MIM:607210 caspase recruitment domain family member 11 GO:0001772,GO:0001819,GO:0002223,GO:0002377,GO:0004385,GO:0005737,GO:0005829,GO:0005886,GO:0007249,GO:0030183,GO:0030890,GO:0031295,GO:0032449,GO:0038095,GO:0038202,GO:0042100,GO:0042102,GO:0042981,GO:0043123,GO:0045061,GO:0045086,GO:0045121,GO:0045577,GO:0045580,GO:0048872,GO:0050700,GO:0050852,GO:0051092,GO:0070062,GO:0070970 immunological synapse|positive regulation of cytokine production|stimulatory C-type lectin receptor signaling pathway|immunoglobulin production|guanylate kinase activity|cytoplasm|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|B cell differentiation|positive regulation of B cell proliferation|T cell costimulation|CBM complex|Fc-epsilon receptor signaling pathway|TORC1 signaling|B cell proliferation|positive regulation of T cell proliferation|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|thymic T cell selection|positive regulation of interleukin-2 biosynthetic process|membrane raft|regulation of B cell differentiation|regulation of T cell differentiation|homeostasis of number of cells|CARD domain binding|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|extracellular exosome|interleukin-2 secretion hsa04064,hsa04660,hsa04662 NF-kappa B signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway CARD14 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0.00869043 0.00812486 GeneID:79092,Genbank:XM_011525213.1,HGNC:HGNC:16446,MIM:607211 caspase recruitment domain family member 14 hsa04064 NF-kappa B signaling pathway CARD16 13.4754700917997 14.8364122276678 12.1145279559317 0.816540263915009 -0.292404067498062 0.741655111222758 1 0.0803262 0.155796 0.116175 0.144186 GeneID:114769,Genbank:XM_011542583.2,HGNC:HGNC:33701,MIM:615680 caspase recruitment domain family member 16 GO:0004869,GO:0010804,GO:0019900,GO:0031665,GO:0032091,GO:0042802,GO:0043123,GO:0043154,GO:0043234,GO:0050700,GO:0050713,GO:0051092,GO:0071222,GO:0071456,GO:0071494,GO:0089720,GO:0097179,GO:0097340 cysteine-type endopeptidase inhibitor activity|negative regulation of tumor necrosis factor-mediated signaling pathway|kinase binding|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein binding|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein complex|CARD domain binding|negative regulation of interleukin-1 beta secretion|positive regulation of NF-kappaB transcription factor activity|cellular response to lipopolysaccharide|cellular response to hypoxia|cellular response to UV-C|caspase binding|protease inhibitor complex|inhibition of cysteine-type endopeptidase activity hsa04621 NOD-like receptor signaling pathway CARD19 326.585943035883 333.781566003375 319.390320068392 0.956884239871901 -0.0635836912463185 0.786807296197447 1 12.2508 15.3579 13.9554 13.5603 GeneID:84270,Genbank:NM_001318010.1,HGNC:HGNC:28148,MIM:617726 caspase recruitment domain family member 19 GO:0005739,GO:0005789,GO:0016021,GO:0031966,GO:0042981 mitochondrion|endoplasmic reticulum membrane|integral component of membrane|mitochondrial membrane|regulation of apoptotic process CARD6 423.07000763437 411.853755391194 434.286259877546 1.05446716023032 0.0765141652969885 0.724668039756573 1 3.28089 3.1582 3.92693 2.85761 GeneID:84674,Genbank:XM_017009989.1,HGNC:HGNC:16394,MIM:609986 caspase recruitment domain family member 6 GO:0006915,GO:0042981 apoptotic process|regulation of apoptotic process hsa04621 NOD-like receptor signaling pathway CARD8 447.287418859972 498.123905444196 396.450932275747 0.79588818754285 -0.32936233071144 0.0686407631319816 0.918202374283561 1.47076 1.37072 1.28772 0.904551 GeneID:22900,Genbank:NM_001351787.1,HGNC:HGNC:17057,MIM:609051 caspase recruitment domain family member 8 GO:0005634,GO:0006915,GO:0042981,GO:0072559 nucleus|apoptotic process|regulation of apoptotic process|NLRP3 inflammasome complex hsa04621 NOD-like receptor signaling pathway CARD9 4.72377883540207 4.11267631439867 5.33488135640547 1.29717997444336 0.375378657094564 0.873481241207411 1 0 0.0213646 0.11547 0 GeneID:64170,Genbank:NM_052814.3,HGNC:HGNC:16391,MIM:607212 caspase recruitment domain family member 9 GO:0002223,GO:0005737,GO:0005829,GO:0005886,GO:0007249,GO:0009620,GO:0032494,GO:0032495,GO:0032755,GO:0032760,GO:0032874,GO:0042534,GO:0042803,GO:0042981,GO:0043123,GO:0043330,GO:0045076,GO:0045087,GO:0045408,GO:0046330,GO:0050700,GO:0050830,GO:0051607 stimulatory C-type lectin receptor signaling pathway|cytoplasm|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|response to fungus|response to peptidoglycan|response to muramyl dipeptide|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of stress-activated MAPK cascade|regulation of tumor necrosis factor biosynthetic process|protein homodimerization activity|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|regulation of interleukin-2 biosynthetic process|innate immune response|regulation of interleukin-6 biosynthetic process|positive regulation of JNK cascade|CARD domain binding|defense response to Gram-positive bacterium|defense response to virus hsa04621,hsa04625,hsa05152 NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Tuberculosis CARF 49.7768031507235 46.2195822623 53.334024039147 1.15392700298484 0.206551962490571 0.810362854660155 1 0.145038 0.201626 0.320826 0.0700283 GeneID:79800,Genbank:NM_001322428.2,HGNC:HGNC:14435,MIM:607586 calcium responsive transcription factor GO:0000978,GO:0001077,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005730,GO:0035865,GO:0061400,GO:0071277 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|nucleolus|cellular response to potassium ion|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|cellular response to calcium ion CARHSP1 1613.41999797606 1565.18416358958 1661.65583236254 1.06163598573072 0.0862891789437192 0.648330974903703 1 15.6658 17.5828 16.5791 18.6603 GeneID:23589,Genbank:NM_014316.3,HGNC:HGNC:17150,MIM:616885 calcium regulated heat stable protein 1 GO:0000177,GO:0000932,GO:0003677,GO:0003730,GO:0005737,GO:0005829,GO:0006355,GO:0019902,GO:0035556,GO:0043186,GO:0043488,GO:0070062 cytoplasmic exosome (RNase complex)|P-body|DNA binding|mRNA 3'-UTR binding|cytoplasm|cytosol|regulation of transcription, DNA-templated|phosphatase binding|intracellular signal transduction|P granule|regulation of mRNA stability|extracellular exosome CARM1 1967.00182217959 1872.31957744363 2061.68406691556 1.10113897849131 0.138996567836479 0.344223445956177 1 18.4923 20.7294 24.0804 21.325 GeneID:10498,Genbank:NM_199141.1,HGNC:HGNC:23393,MIM:603934 coactivator associated arginine methyltransferase 1 GO:0001105,GO:0003420,GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006977,GO:0007568,GO:0008013,GO:0008276,GO:0008284,GO:0008469,GO:0016032,GO:0016274,GO:0016571,GO:0019216,GO:0030374,GO:0030520,GO:0032091,GO:0033146,GO:0034970,GO:0034971,GO:0035242,GO:0035642,GO:0042054,GO:0042803,GO:0044212,GO:0045600,GO:0051092,GO:0051591,GO:0060350,GO:0070577,GO:0071168,GO:0090575,GO:1902415,GO:2000171 RNA polymerase II transcription coactivator activity|regulation of growth plate cartilage chondrocyte proliferation|transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|aging|beta-catenin binding|protein methyltransferase activity|positive regulation of cell proliferation|histone-arginine N-methyltransferase activity|viral process|protein-arginine N-methyltransferase activity|histone methylation|regulation of lipid metabolic process|ligand-dependent nuclear receptor transcription coactivator activity|intracellular estrogen receptor signaling pathway|negative regulation of protein binding|regulation of intracellular estrogen receptor signaling pathway|histone H3-R2 methylation|histone H3-R17 methylation|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity (H3-R17 specific)|histone methyltransferase activity|protein homodimerization activity|transcription regulatory region DNA binding|positive regulation of fat cell differentiation|positive regulation of NF-kappaB transcription factor activity|response to cAMP|endochondral bone morphogenesis|lysine-acetylated histone binding|protein localization to chromatin|RNA polymerase II transcription factor complex|regulation of mRNA binding|negative regulation of dendrite development hsa01522 Endocrine resistance CARMIL1 577.740315697354 555.913096254733 599.567535139975 1.07852745182538 0.109062897971069 0.61270804183618 1 2.18498 2.15825 2.85577 1.86206 GeneID:55604,Genbank:XM_017011008.1,HGNC:HGNC:21581,MIM:609593 capping protein regulator and myosin 1 linker 1 GO:0005634,GO:0005829,GO:0005886,GO:0007015,GO:0007596,GO:0016477,GO:0016607,GO:0030027,GO:0030032,GO:0030335,GO:0030838,GO:0031252,GO:0031529,GO:0031941,GO:0032403,GO:0044351,GO:0044354,GO:0046415,GO:0051496,GO:0051638,GO:0051639,GO:0070062,GO:1900026,GO:1902745,GO:2000813 nucleus|cytosol|plasma membrane|actin filament organization|blood coagulation|cell migration|nuclear speck|lamellipodium|lamellipodium assembly|positive regulation of cell migration|positive regulation of actin filament polymerization|cell leading edge|ruffle organization|filamentous actin|protein complex binding|macropinocytosis|macropinosome|urate metabolic process|positive regulation of stress fiber assembly|barbed-end actin filament uncapping|actin filament network formation|extracellular exosome|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of lamellipodium organization|negative regulation of barbed-end actin filament capping CARMIL2 14.553297022716 17.4788743361943 11.6277197092377 0.6652441962558 -0.588044075990111 0.453496027972542 1 0.127895 0.0888759 0.063954 0.129647 GeneID:146206,Genbank:NM_001013838.2,HGNC:HGNC:27089,MIM:610859 capping protein regulator and myosin 1 linker 2 GO:0001726,GO:0005543,GO:0005737,GO:0005886,GO:0007163,GO:0010592,GO:0015629,GO:0016020,GO:0030011,GO:0030027,GO:0030335,GO:0031234,GO:0031252,GO:0032403,GO:0044319,GO:0044354,GO:0045111,GO:0051639,GO:0061339,GO:0090091,GO:1900029,GO:1902745,GO:2000813 ruffle|phospholipid binding|cytoplasm|plasma membrane|establishment or maintenance of cell polarity|positive regulation of lamellipodium assembly|actin cytoskeleton|membrane|maintenance of cell polarity|lamellipodium|positive regulation of cell migration|extrinsic component of cytoplasmic side of plasma membrane|cell leading edge|protein complex binding|wound healing, spreading of cells|macropinosome|intermediate filament cytoskeleton|actin filament network formation|establishment or maintenance of monopolar cell polarity|positive regulation of extracellular matrix disassembly|positive regulation of ruffle assembly|positive regulation of lamellipodium organization|negative regulation of barbed-end actin filament capping CARMIL3 3.10308228774458 5.23689794236822 0.969266633120943 0.185084117312896 -2.43374699685365 0.234845579374409 1 0.0419287 0.00727373 0.00775614 0 GeneID:90668,Genbank:NM_138360.3,HGNC:HGNC:20272,MIM:614716 capping protein regulator and myosin 1 linker 3 GO:0005737,GO:0005886 cytoplasm|plasma membrane CARNMT1 135.469483701505 154.609571987429 116.329395415581 0.752407460419328 -0.410413941060004 0.134267774491612 1 1.21364 1.00894 1.03533 0.690105 GeneID:138199,Genbank:NM_152420.2,HGNC:HGNC:23435,MIM:616552 carnosine N-methyltransferase 1 GO:0005634,GO:0005829,GO:0006548,GO:0030735,GO:0035498 nucleus|cytosol|histidine catabolic process|carnosine N-methyltransferase activity|carnosine metabolic process hsa00340 Histidine metabolism CARNS1 0.998282869833606 1.02816907859967 0.968396661067546 0.941865186596032 -0.0864075197076174 1 1 0.0078485 0.00678031 0 0.013605 GeneID:57571,Genbank:XM_017018054.1,HGNC:HGNC:29268,MIM:613368 carnosine synthase 1 GO:0005524,GO:0005829,GO:0006548,GO:0016887,GO:0035499,GO:0046872,GO:0047730,GO:0102102 ATP binding|cytosol|histidine catabolic process|ATPase activity|carnosine biosynthetic process|metal ion binding|carnosine synthase activity|homocarnosine synthase activity hsa00330,hsa00340,hsa00410 Arginine and proline metabolism|Histidine metabolism|beta-Alanine metabolism CARS 1870.19543357149 1861.22819764053 1879.16266950245 1.00963582643152 0.0138350096665014 0.950887785477547 1 11.9983 12.7605 11.1409 13.9811 GeneID:833,Genbank:NM_001751.5,HGNC:HGNC:1493,MIM:123859 cysteinyl-tRNA synthetase GO:0000049,GO:0004817,GO:0005524,GO:0005737,GO:0005829,GO:0006423,GO:0042803,GO:0046872 tRNA binding|cysteine-tRNA ligase activity|ATP binding|cytoplasm|cytosol|cysteinyl-tRNA aminoacylation|protein homodimerization activity|metal ion binding hsa00970 Aminoacyl-tRNA biosynthesis CARS2 1424.63813439917 1449.25978939061 1400.01647940773 0.96602175100464 -0.0498724216511089 0.716100543122127 1 6.62213 7.54984 6.72004 7.16224 GeneID:79587,Genbank:NM_001352252.1,HGNC:HGNC:25695,MIM:612800 cysteinyl-tRNA synthetase 2, mitochondrial GO:0004817,GO:0005524,GO:0005737,GO:0005759,GO:0006423,GO:0046872 cysteine-tRNA ligase activity|ATP binding|cytoplasm|mitochondrial matrix|cysteinyl-tRNA aminoacylation|metal ion binding hsa00970 Aminoacyl-tRNA biosynthesis CASC1 0.996651292201907 0.538097676642304 1.45520490776151 2.70435084730694 1.43528233092293 0.835161298535314 1 0 0 0.0191449 0 GeneID:55259,Genbank:XM_011520723.1,HGNC:HGNC:29599,MIM:616906 cancer susceptibility 1 CASC10 508.077726538433 432.216240210194 583.939212866672 1.35103487222667 0.434064913256631 0.0133942543967807 0.475659375651531 11.7952 12.7542 15.6244 17.5441 GeneID:399726,Genbank:NM_001010911.2,HGNC:HGNC:31448 cancer susceptibility 10 CASC3 2625.47019067036 2457.0880344832 2793.85234685751 1.13705830139096 0.185306228699136 0.185352732182298 1 19.6135 21.6356 23.918 23.3743 GeneID:22794,Genbank:NM_007359.4,HGNC:HGNC:17040,MIM:606504 cancer susceptibility 3 hsa03013,hsa03015 RNA transport|mRNA surveillance pathway CASC4 2222.45952821059 2515.06221138649 1929.85684503468 0.76731972525276 -0.382100252591295 0.0326393449473841 0.714141733165715 25.7381 22.0741 19.659 17.0977 GeneID:113201,Genbank:XM_017021880.2,HGNC:HGNC:24892 cancer susceptibility 4 GO:0016021 integral component of membrane CASD1 250.047863915079 266.977967858011 233.117759972147 0.873172276508332 -0.195661769848272 0.368277424157797 1 1.51322 1.42193 1.52461 1.07918 GeneID:64921,Genbank:NM_022900.4,HGNC:HGNC:16014,MIM:611686 CAS1 domain containing 1 GO:0005975,GO:0030173,GO:0047186 carbohydrate metabolic process|integral component of Golgi membrane|N-acetylneuraminate 7-O(or 9-O)-acetyltransferase activity CASK 542.157453072083 557.959625756824 526.355280387342 0.943357289827891 -0.0841238100558265 0.636087874501793 1 2.06525 2.03221 2.17183 1.64897 GeneID:8573,Genbank:XM_006724566.3,HGNC:HGNC:1497,MIM:300172 calcium/calmodulin dependent serine protein kinase GO:0001953,GO:0004385,GO:0004674,GO:0005516,GO:0005524,GO:0005604,GO:0005652,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0007155,GO:0007269,GO:0010839,GO:0015629,GO:0016323,GO:0016363,GO:0031982,GO:0042043,GO:0042734,GO:0045944,GO:0060170,GO:0061045,GO:0070509,GO:0090280,GO:0090288 negative regulation of cell-matrix adhesion|guanylate kinase activity|protein serine/threonine kinase activity|calmodulin binding|ATP binding|basement membrane|nuclear lamina|nucleolus|cytoplasm|cytosol|plasma membrane|cell-cell junction|focal adhesion|cell adhesion|neurotransmitter secretion|negative regulation of keratinocyte proliferation|actin cytoskeleton|basolateral plasma membrane|nuclear matrix|vesicle|neurexin family protein binding|presynaptic membrane|positive regulation of transcription from RNA polymerase II promoter|ciliary membrane|negative regulation of wound healing|calcium ion import|positive regulation of calcium ion import|negative regulation of cellular response to growth factor stimulus CASKIN1 90.1410172499943 87.7305556037662 92.5514788962224 1.05495147339805 0.0771766380811466 0.798048840020315 1 0.86843 0.552112 0.662665 0.788909 GeneID:57524,Genbank:NM_020764.3,HGNC:HGNC:20879,MIM:612184 CASK interacting protein 1 GO:0005737,GO:0007165,GO:0016020,GO:0042802 cytoplasm|signal transduction|membrane|identical protein binding CASKIN2 704.846086766733 663.353386142126 746.33878739134 1.12509983815992 0.170053027777728 0.314501737986562 1 4.55112 5.08608 5.69727 5.22569 GeneID:57513,Genbank:NM_020753.4,HGNC:HGNC:18200,MIM:612185 CASK interacting protein 2 GO:0005737,GO:0016020 cytoplasm|membrane CASP1 35.0371561395573 31.2871174852624 38.7871947938523 1.23971774683694 0.310011691910219 0.70934864227004 1 0.311233 0.372756 0.64934 0.173911 GeneID:834,Genbank:XM_017018395.1,HGNC:HGNC:1499,MIM:147678 caspase 1 hsa04217,hsa04621,hsa04623,hsa04625,hsa05014,hsa05132,hsa05133,hsa05134,hsa05164 Necroptosis|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|Amyotrophic lateral sclerosis (ALS)|Salmonella infection|Pertussis|Legionellosis|Influenza A CASP10 3.48622496953828 4.06465003971372 2.90779989936283 0.715387516994606 -0.483203150341056 0.844725913131162 1 0.0178804 0.027794 0 0.0158569 GeneID:843,Genbank:NM_001306083.1,HGNC:HGNC:1500,MIM:601762 caspase 10 hsa04210,hsa04622,hsa04668,hsa05152,hsa05161 Apoptosis|RIG-I-like receptor signaling pathway|TNF signaling pathway|Tuberculosis|Hepatitis B CASP2 2027.7604435945 2072.28999940072 1983.23088778828 0.957023818269553 -0.0633732641449654 0.661675168785195 1 21.2097 19.6225 22.178 17.6964 GeneID:835,Genbank:NM_032982.3,HGNC:HGNC:1503,MIM:600639 caspase 2 hsa04210 Apoptosis CASP3 293.058280225621 317.598384082819 268.518176368423 0.845464554688675 -0.242183822625595 0.260844966517494 1 4.6634 4.19493 4.61569 3.17773 GeneID:836,Genbank:NM_001354784.1,HGNC:HGNC:1504,MIM:600636 caspase 3 hsa01524,hsa04010,hsa04115,hsa04210,hsa04215,hsa04650,hsa04657,hsa04668,hsa04726,hsa04932,hsa04933,hsa05010,hsa05012,hsa05014,hsa05016,hsa05120,hsa05133,hsa05134,hsa05145,hsa05146,hsa05152,hsa05161,hsa05163,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05222,hsa05416 Platinum drug resistance|MAPK signaling pathway|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|TNF signaling pathway|Serotonergic synapse|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis (ALS)|Huntington disease|Epithelial cell signaling in Helicobacter pylori infection|Pertussis|Legionellosis|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Small cell lung cancer|Viral myocarditis CASP4 596.49582377043 564.906869278489 628.084778262371 1.11183774250183 0.152946261831111 0.353841235390361 1 7.9923 7.6786 9.08717 9.08457 GeneID:837,Genbank:XM_011543019.1,HGNC:HGNC:1505,MIM:602664 caspase 4 hsa04621 NOD-like receptor signaling pathway CASP6 502.283877899554 508.377187265723 496.190568533384 0.976028391836611 -0.0350049797158827 0.8877993593213 1 12.1019 11.6517 10.1781 13.3299 GeneID:839,Genbank:NM_032992.2,HGNC:HGNC:1507,MIM:601532 caspase 6 hsa04210 Apoptosis CASP7 789.332054269474 504.072405852585 1074.59170268636 2.13182013180985 1.09208571863516 0.00103897438392151 0.1041019983757 3.92921 3.89885 9.93654 6.73896 GeneID:840,Genbank:NM_001320911.1,HGNC:HGNC:1508,MIM:601761 caspase 7 GO:0004197,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0008233,GO:0008234,GO:0008635,GO:0072734,GO:0097194,GO:0097200 cysteine-type endopeptidase activity|nucleus|nucleoplasm|cytoplasm|cytosol|proteolysis|apoptotic process|peptidase activity|cysteine-type peptidase activity|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|cellular response to staurosporine|execution phase of apoptosis|cysteine-type endopeptidase activity involved in execution phase of apoptosis hsa04210,hsa04215,hsa04668,hsa04932,hsa05010,hsa05133,hsa05134,hsa05200 Apoptosis|Apoptosis - multiple species|TNF signaling pathway|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Pertussis|Legionellosis|Pathways in cancer CASP8 316.407712807854 338.623428092301 294.191997523408 0.868788078783544 -0.202923787783139 0.304781335928353 1 2.87148 2.69002 2.68809 2.16139 GeneID:841,Genbank:NM_001228.4,HGNC:HGNC:1509,MIM:601763 caspase 8 hsa01524,hsa04115,hsa04210,hsa04215,hsa04217,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04668,hsa04932,hsa05010,hsa05016,hsa05134,hsa05142,hsa05145,hsa05152,hsa05161,hsa05163,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05416 Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Huntington disease|Legionellosis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Viral myocarditis CASP8AP2 98.5067586360889 100.068584546962 96.9449327252156 0.968784890523952 -0.0457517304085384 0.929962256058211 1 0.443688 0.395916 0.496387 0.311424 GeneID:9994,Genbank:NM_012115.3,HGNC:HGNC:1510,MIM:606880 caspase 8 associated protein 2 GO:0003677,GO:0003714,GO:0005123,GO:0005634,GO:0005737,GO:0005739,GO:0006351,GO:0006355,GO:0006919,GO:0007049,GO:0007165,GO:0008625,GO:0008656,GO:0016505,GO:0016605,GO:0032184,GO:0036337,GO:0071260,GO:0097190 DNA binding|transcription corepressor activity|death receptor binding|nucleus|cytoplasm|mitochondrion|transcription, DNA-templated|regulation of transcription, DNA-templated|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell cycle|signal transduction|extrinsic apoptotic signaling pathway via death domain receptors|cysteine-type endopeptidase activator activity involved in apoptotic process|peptidase activator activity involved in apoptotic process|PML body|SUMO polymer binding|Fas signaling pathway|cellular response to mechanical stimulus|apoptotic signaling pathway CASP9 366.567127922781 386.620999518798 346.513256326764 0.896260825868346 -0.158009454760687 0.397465877032072 1 3.58809 3.88749 3.61426 3.23049 GeneID:842,Genbank:NM_032996.3,HGNC:HGNC:1511,MIM:602234 caspase 9 hsa01524,hsa04115,hsa04151,hsa04210,hsa04215,hsa04370,hsa04919,hsa05010,hsa05012,hsa05014,hsa05016,hsa05134,hsa05145,hsa05152,hsa05161,hsa05163,hsa05164,hsa05167,hsa05169,hsa05170,hsa05200,hsa05210,hsa05212,hsa05213,hsa05215,hsa05222,hsa05223,hsa05416 Platinum drug resistance|p53 signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Apoptosis - multiple species|VEGF signaling pathway|Thyroid hormone signaling pathway|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis (ALS)|Huntington disease|Legionellosis|Toxoplasmosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Prostate cancer|Small cell lung cancer|Non-small cell lung cancer|Viral myocarditis CASQ1 2.34059052572757 3.22858605985383 1.45259499160132 0.449916763769675 -1.15226997256519 0.767624024401618 1 0.111826 0 0 0.0495197 GeneID:844,Genbank:NM_001231.4,HGNC:HGNC:1512,MIM:114250 calsequestrin 1 CASQ2 13.3829832962648 10.771762187954 15.9942044045757 1.48482709936373 0.57029494623605 0.488803279254092 1 0.0965708 0.129637 0.224564 0.18391 GeneID:845,Genbank:NM_001232.3,HGNC:HGNC:1513,MIM:114251 calsequestrin 2 CASS4 2.48707212765127 3.03648096111406 1.93766329418849 0.638127924726911 -0.648082426588456 0.834080190590241 1 0.0088021 0.0320873 0.00828998 0.00774067 GeneID:57091,Genbank:XM_006723831.3,HGNC:HGNC:15878 Cas scaffold protein family member 4 GO:0005737,GO:0005856,GO:0005925,GO:0007155 cytoplasm|cytoskeleton|focal adhesion|cell adhesion CAST 4361.66595196642 4544.16438583519 4179.16751809765 0.919677890862557 -0.12079943657118 0.368963562818423 1 24.2316 24.1031 24.0427 20.1126 GeneID:831,Genbank:NM_001042442.2,HGNC:HGNC:1515,MIM:114090 calpastatin GO:0003723,GO:0004866,GO:0005783,GO:0005829,GO:0010859,GO:0016020,GO:0045296,GO:0097340,GO:2000675 RNA binding|endopeptidase inhibitor activity|endoplasmic reticulum|cytosol|calcium-dependent cysteine-type endopeptidase inhibitor activity|membrane|cadherin binding|inhibition of cysteine-type endopeptidase activity|negative regulation of type B pancreatic cell apoptotic process CASTOR1 44.3942461601647 51.9563602617336 36.8321320585958 0.708905163353467 -0.496335456859929 0.240251113671852 1 1.28642 1.745 1.18432 0.759389 GeneID:652968,Genbank:NM_001037666.2,HGNC:HGNC:34423,MIM:617034 cytosolic arginine sensor for mTORC1 subunit 1 GO:0005829,GO:0034618,GO:0042802,GO:1903577,GO:1904262 cytosol|arginine binding|identical protein binding|cellular response to L-arginine|negative regulation of TORC1 signaling CASTOR2 384.908052001246 377.251807951816 392.564296050676 1.04058956849536 0.0574011500445421 0.760675224049166 1 1.97617 1.93168 2.22181 1.96963 GeneID:729438,Genbank:XM_017012574.1,HGNC:HGNC:37073,MIM:617033 cytosolic arginine sensor for mTORC1 subunit 2 GO:0005829,GO:0042802,GO:1904262 cytosol|identical protein binding|negative regulation of TORC1 signaling CASTOR3 344.007773527272 301.763228741876 386.252318312669 1.27998470828619 0.356126574747574 0.0653192556871715 0.901277047586747 0.849976 0.900565 1.16152 1.12941 GeneID:352954,Genbank:XM_017012156.1,HGNC:HGNC:29954 CASTOR family member 3 CASZ1 25.9557022159527 28.6446553767358 23.2667490551696 0.812254458961515 -0.299996336475407 0.605225188296533 1 0.11294 0.111145 0.11895 0.0696417 GeneID:54897,Genbank:NM_001079843.2,HGNC:HGNC:26002,MIM:609895 castor zinc finger 1 CAT 1024.47567178512 987.600030442538 1061.3513131277 1.07467727866727 0.103903489241239 0.488893943696582 1 16.6058 16.0865 18.3179 16.7724 GeneID:847,Genbank:NM_001752.3,HGNC:HGNC:1516,MIM:115500 catalase hsa00380,hsa00630,hsa04068,hsa04146,hsa04211,hsa04213,hsa05014 Tryptophan metabolism|Glyoxylate and dicarboxylate metabolism|FoxO signaling pathway|Peroxisome|Longevity regulating pathway|Longevity regulating pathway - multiple species|Amyotrophic lateral sclerosis (ALS) CATSPER1 10.417912529055 9.20549543271206 11.6303296253979 1.26341159043642 0.337324712560054 0.753873860782532 1 0.0453222 0.0791323 0.111639 0.14412 GeneID:117144,Genbank:NM_053054.3,HGNC:HGNC:17116,MIM:606389 cation channel sperm associated 1 GO:0005227,GO:0005886,GO:0007275,GO:0007283,GO:0008331,GO:0030154,GO:0030317,GO:0031514,GO:0032570,GO:0034765,GO:0035036,GO:0036128,GO:0086010 calcium activated cation channel activity|plasma membrane|multicellular organism development|spermatogenesis|high voltage-gated calcium channel activity|cell differentiation|flagellated sperm motility|motile cilium|response to progesterone|regulation of ion transmembrane transport|sperm-egg recognition|CatSper complex|membrane depolarization during action potential CATSPER2 27.9362899136397 26.7902309733842 29.0823488538953 1.08555797382965 0.118436774615566 0.890779380304289 1 0.079308 0.146641 0.17556 0.233203 GeneID:117155,Genbank:NM_001282310.2,HGNC:HGNC:18810,MIM:607249 cation channel sperm associated 2 GO:0005227,GO:0005244,GO:0005248,GO:0005262,GO:0005886,GO:0007275,GO:0007283,GO:0019228,GO:0030154,GO:0030317,GO:0031514,GO:0032570,GO:0034765,GO:0035036,GO:0036128,GO:0086010 calcium activated cation channel activity|voltage-gated ion channel activity|voltage-gated sodium channel activity|calcium channel activity|plasma membrane|multicellular organism development|spermatogenesis|neuronal action potential|cell differentiation|flagellated sperm motility|motile cilium|response to progesterone|regulation of ion transmembrane transport|sperm-egg recognition|CatSper complex|membrane depolarization during action potential CATSPER3 15.3378308186974 13.7121905996982 16.9634710376966 1.23710875475068 0.306972333816873 0.723151975239366 1 0.227531 0.449372 0.465639 0.399142 GeneID:347732,Genbank:NM_178019.2,HGNC:HGNC:20819,MIM:609120 cation channel sperm associated 3 GO:0001669,GO:0005245,GO:0005261,GO:0005783,GO:0005886,GO:0006814,GO:0006816,GO:0007275,GO:0030317,GO:0031514,GO:0032570,GO:0034220,GO:0034765,GO:0035036,GO:0036128,GO:0048240,GO:0086010 acrosomal vesicle|voltage-gated calcium channel activity|cation channel activity|endoplasmic reticulum|plasma membrane|sodium ion transport|calcium ion transport|multicellular organism development|flagellated sperm motility|motile cilium|response to progesterone|ion transmembrane transport|regulation of ion transmembrane transport|sperm-egg recognition|CatSper complex|sperm capacitation|membrane depolarization during action potential CATSPER4 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0151091 0 0 GeneID:378807,Genbank:XM_011541433.2,HGNC:HGNC:23220,MIM:609121 cation channel sperm associated 4 GO:0001669,GO:0005227,GO:0005245,GO:0005886,GO:0006814,GO:0006816,GO:0007275,GO:0030317,GO:0032570,GO:0034765,GO:0035036,GO:0036128,GO:0048240,GO:0072345,GO:0086010,GO:0097228 acrosomal vesicle|calcium activated cation channel activity|voltage-gated calcium channel activity|plasma membrane|sodium ion transport|calcium ion transport|multicellular organism development|flagellated sperm motility|response to progesterone|regulation of ion transmembrane transport|sperm-egg recognition|CatSper complex|sperm capacitation|NAADP-sensitive calcium-release channel activity|membrane depolarization during action potential|sperm principal piece CATSPERD 2.56541959712897 4.16070258908361 0.97013660517434 0.233166534834688 -2.10056735391568 0.364208530816 1 0 0 0.0127308 0 GeneID:257062,Genbank:XM_011527885.3,HGNC:HGNC:28598,MIM:617490 cation channel sperm associated auxiliary subunit delta GO:0005886,GO:0007275,GO:0007283,GO:0030317,GO:0032570,GO:0035036,GO:0036128,GO:0048240,GO:0097228 plasma membrane|multicellular organism development|spermatogenesis|flagellated sperm motility|response to progesterone|sperm-egg recognition|CatSper complex|sperm capacitation|sperm principal piece CATSPERE 6.33633192122219 7.34126237425249 5.33140146819188 0.726224073790135 -0.461513339684548 0.772289054478121 1 0.030772 0.0222484 0.0149021 0.00691277 GeneID:257044,Genbank:XM_011544142.3,HGNC:HGNC:28491,MIM:617510 catsper channel auxiliary subunit epsilon GO:0036128,GO:0097228 CatSper complex|sperm principal piece CATSPERG 3.48035189811469 3.084507235799 3.87619656043037 1.25666638594424 0.32960170049408 0.933617934026868 1 0.00693353 0 0 0.012134 GeneID:57828,Genbank:XM_011527178.2,HGNC:HGNC:25243,MIM:613452 cation channel sperm associated auxiliary subunit gamma GO:0005886,GO:0007275,GO:0007283,GO:0030154,GO:0032570,GO:0035036,GO:0036128,GO:0097228 plasma membrane|multicellular organism development|spermatogenesis|cell differentiation|response to progesterone|sperm-egg recognition|CatSper complex|sperm principal piece CATSPERZ 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0626409 GeneID:25858,Genbank:NM_001039496.1,HGNC:HGNC:19231,MIM:617511 catsper channel auxiliary subunit zeta GO:0005737,GO:0007140,GO:0007283,GO:0030317,GO:0036128,GO:0048240,GO:0097228 cytoplasm|male meiotic nuclear division|spermatogenesis|flagellated sperm motility|CatSper complex|sperm capacitation|sperm principal piece CAV1 14053.7942467491 14284.844097388 13822.7443961102 0.967651050433073 -0.0474412112001455 0.73589612988957 1 187.093 172.922 194.004 155.146 GeneID:857,Genbank:NM_001753.4,HGNC:HGNC:1527,MIM:601047 caveolin 1 hsa04144,hsa04510,hsa05100,hsa05205,hsa05416,hsa05418 Endocytosis|Focal adhesion|Bacterial invasion of epithelial cells|Proteoglycans in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis CAV2 3402.76553770858 3694.56933464332 3110.96174077383 0.842036367162716 -0.248045550916026 0.0677537609750469 0.916343630061028 48.6472 49.4099 45.0492 37.966 GeneID:858,Genbank:NM_001233.4,HGNC:HGNC:1528,MIM:601048 caveolin 2 GO:0005829,GO:0016020,GO:0042803,GO:0070062 cytosol|membrane|protein homodimerization activity|extracellular exosome hsa04144,hsa04510,hsa05100,hsa05205,hsa05418 Endocytosis|Focal adhesion|Bacterial invasion of epithelial cells|Proteoglycans in cancer|Fluid shear stress and atherosclerosis CAV3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:859,Genbank:NM_033337.2,HGNC:HGNC:1529,MIM:601253 caveolin 3 hsa04144,hsa04510,hsa05100,hsa05205,hsa05418 Endocytosis|Focal adhesion|Bacterial invasion of epithelial cells|Proteoglycans in cancer|Fluid shear stress and atherosclerosis CAVIN1 20857.4561527086 19329.1103246432 22385.801980774 1.15813928343271 0.211808769245923 0.104510538816451 1 164.77 172.804 200.833 195.308 GeneID:284119,Genbank:NM_012232.5,HGNC:HGNC:9688,MIM:603198 caveolae associated protein 1 GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0005901,GO:0006355,GO:0006361,GO:0006363,GO:0009303,GO:0042134,GO:0042802,GO:0043231,GO:0043234,GO:0045121,GO:2000147 RNA binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|caveola|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|termination of RNA polymerase I transcription|rRNA transcription|rRNA primary transcript binding|identical protein binding|intracellular membrane-bounded organelle|protein complex|membrane raft|positive regulation of cell motility CAVIN2 182.906967397659 191.335501168908 174.47843362641 0.911897857744569 -0.133055858631137 0.590421134645889 1 2.32588 2.14635 2.26667 1.80681 GeneID:8436,Genbank:NM_004657.5,HGNC:HGNC:10690,MIM:606728 caveolae associated protein 2 GO:0001786,GO:0005080,GO:0005543,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005901,GO:0015629,GO:0045121,GO:0097320 phosphatidylserine binding|protein kinase C binding|phospholipid binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|caveola|actin cytoskeleton|membrane raft|plasma membrane tubulation CAVIN3 39.1774095537239 31.3449524150553 47.0098666923924 1.49975875126271 0.584730449822056 0.219148808272133 1 1.33006 2.31961 2.99 2.67727 GeneID:112464,Genbank:NM_145040.2,HGNC:HGNC:9400 caveolae associated protein 3 GO:0005080,GO:0005737,GO:0005829,GO:0005901,GO:0030866,GO:0032922,GO:0043234,GO:0051898,GO:0070374,GO:1901003 protein kinase C binding|cytoplasm|cytosol|caveola|cortical actin cytoskeleton organization|circadian regulation of gene expression|protein complex|negative regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|negative regulation of fermentation CAVIN4 14.7432367859812 16.4026789829097 13.0837945890526 0.797662052807648 -0.326150448697368 0.693050716472534 1 0.17055 0.198361 0.117045 0.163556 GeneID:347273,Genbank:NM_001018116.2,HGNC:HGNC:33742,MIM:617714 caveolae associated protein 4 GO:0005737,GO:0005829,GO:0005886,GO:0005901,GO:0006351,GO:0007517,GO:0010468,GO:0030018,GO:0030154,GO:0035023,GO:0042383,GO:0045944 cytoplasm|cytosol|plasma membrane|caveola|transcription, DNA-templated|muscle organ development|regulation of gene expression|Z disc|cell differentiation|regulation of Rho protein signal transduction|sarcolemma|positive regulation of transcription from RNA polymerase II promoter CBARP 182.139279824302 194.669948433239 169.608611215364 0.871262424326012 -0.198820770723265 0.408141509414835 1 1.60435 1.31027 1.16766 1.26763 GeneID:255057,Genbank:XM_017026555.1,HGNC:HGNC:28617 CACN beta subunit associated regulatory protein GO:0005886,GO:0016021,GO:0030054,GO:0030141,GO:0030426,GO:0030672,GO:0044325,GO:0045955,GO:1901386,GO:1903170 plasma membrane|integral component of membrane|cell junction|secretory granule|growth cone|synaptic vesicle membrane|ion channel binding|negative regulation of calcium ion-dependent exocytosis|negative regulation of voltage-gated calcium channel activity|negative regulation of calcium ion transmembrane transport CBFA2T2 584.817518529974 590.938488512022 578.696548547926 0.979283901451535 -0.0302009267438559 0.856203251115323 1 2.42273 2.52887 2.63534 2.13646 GeneID:9139,Genbank:XM_017028122.2,HGNC:HGNC:1536,MIM:603672 CBFA2/RUNX1 translocation partner 2 GO:0000122,GO:0003700,GO:0003714,GO:0005634,GO:0006351,GO:0010976,GO:0010977,GO:0045746,GO:0045892,GO:0046872,GO:0060575 negative regulation of transcription from RNA polymerase II promoter|DNA binding transcription factor activity|transcription corepressor activity|nucleus|transcription, DNA-templated|positive regulation of neuron projection development|negative regulation of neuron projection development|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|metal ion binding|intestinal epithelial cell differentiation CBFB 1728.19273848249 2139.65807018548 1316.72740677949 0.615391508169971 -0.700423558927309 1.12016993840093e-06 0.000815483715155879 38.1833 35.916 23.7684 22.8587 GeneID:865,Genbank:NM_001755.2,HGNC:HGNC:1539,MIM:121360 core-binding factor beta subunit GO:0000209,GO:0001503,GO:0001649,GO:0003677,GO:0003713,GO:0005634,GO:0005654,GO:0030098,GO:0030099,GO:0043234,GO:0045944,GO:0048469,GO:0060216 protein polyubiquitination|ossification|osteoblast differentiation|DNA binding|transcription coactivator activity|nucleus|nucleoplasm|lymphocyte differentiation|myeloid cell differentiation|protein complex|positive regulation of transcription from RNA polymerase II promoter|cell maturation|definitive hemopoiesis CBL 1483.60463333228 1563.0199302262 1404.18933643837 0.898382233830606 -0.154598697222219 0.495992210229164 1 6.09072 6.13093 6.70193 4.52455 GeneID:867,Genbank:NM_005188.3,HGNC:HGNC:1541,MIM:165360 Cbl proto-oncogene hsa04012,hsa04120,hsa04144,hsa04910,hsa05100,hsa05200,hsa05205,hsa05220 ErbB signaling pathway|Ubiquitin mediated proteolysis|Endocytosis|Insulin signaling pathway|Bacterial invasion of epithelial cells|Pathways in cancer|Proteoglycans in cancer|Chronic myeloid leukemia CBLB 130.363573243554 125.974725265802 134.752421221306 1.06967823058938 0.0971768854617705 0.76035236267828 1 0.466785 0.438922 0.560252 0.39711 GeneID:868,Genbank:XM_011513257.1,HGNC:HGNC:1542,MIM:604491 Cbl proto-oncogene B hsa04012,hsa04120,hsa04144,hsa04625,hsa04660,hsa04910,hsa05162 ErbB signaling pathway|Ubiquitin mediated proteolysis|Endocytosis|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|Insulin signaling pathway|Measles CBLL1 593.905554595344 650.302737732055 537.508371458633 0.826550989671681 -0.274824273219261 0.104004345773446 1 2.78353 2.75846 2.66807 1.94576 GeneID:79872,Genbank:NM_024814.3,HGNC:HGNC:21225,MIM:606872 Cbl proto-oncogene like 1 GO:0004842,GO:0007162,GO:0016607,GO:0030335,GO:0045807,GO:0046872 ubiquitin-protein transferase activity|negative regulation of cell adhesion|nuclear speck|positive regulation of cell migration|positive regulation of endocytosis|metal ion binding CBLN1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0209599 GeneID:869,Genbank:NM_004352.3,HGNC:HGNC:1543,MIM:600432 cerebellin 1 precursor GO:0005576,GO:0007157,GO:0007268,GO:0007399,GO:0009306,GO:0021707,GO:0030054,GO:0042803,GO:0045211,GO:0051965,GO:0090394,GO:1900454 extracellular region|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|chemical synaptic transmission|nervous system development|protein secretion|cerebellar granule cell differentiation|cell junction|protein homodimerization activity|postsynaptic membrane|positive regulation of synapse assembly|negative regulation of excitatory postsynaptic potential|positive regulation of long term synaptic depression CBLN3 6.41597144258518 3.6226049124413 9.20933797272905 2.5421866848082 1.34606997816258 0.26812594832183 1 0.0790457 0.034834 0.183652 0.120408 GeneID:643866,Genbank:NM_001039771.2,HGNC:HGNC:20146,MIM:612978 cerebellin 3 precursor GO:0005615,GO:0005783,GO:0005794,GO:0030054,GO:0045202 extracellular space|endoplasmic reticulum|Golgi apparatus|cell junction|synapse CBR1 1781.91080127154 1683.5852697611 1880.23633278198 1.11680493204171 0.15937721791415 0.263388375978832 1 32.1772 32.0761 33.484 37.8572 GeneID:873,Genbank:NM_001286789.1,HGNC:HGNC:1548,MIM:114830 carbonyl reductase 1 hsa00590,hsa00790,hsa00980,hsa05204 Arachidonic acid metabolism|Folate biosynthesis|Metabolism of xenobiotics by cytochrome P450|Chemical carcinogenesis CBR3 220.373269495225 216.386977598526 224.359561391923 1.03684410162699 0.0521989889268026 0.864185996118715 1 3.77728 5.66991 4.66129 5.52098 GeneID:874,Genbank:XM_011529772.2,HGNC:HGNC:1549,MIM:603608 carbonyl reductase 3 hsa00590,hsa00980 Arachidonic acid metabolism|Metabolism of xenobiotics by cytochrome P450 CBR4 371.255016950614 406.203221286022 336.306812615205 0.827927487995964 -0.272423676546358 0.203307379923847 1 2.73391 2.55999 2.2242 2.39326 GeneID:84869,Genbank:XM_017008782.1,HGNC:HGNC:25891 carbonyl reductase 4 GO:0003955,GO:0005759,GO:0006633,GO:0008753,GO:0044597,GO:0044598,GO:0046949,GO:0047025,GO:0048038,GO:0051289,GO:0051290,GO:0055114,GO:0070402,GO:1990204 NAD(P)H dehydrogenase (quinone) activity|mitochondrial matrix|fatty acid biosynthetic process|NADPH dehydrogenase (quinone) activity|daunorubicin metabolic process|doxorubicin metabolic process|fatty-acyl-CoA biosynthetic process|3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity|quinone binding|protein homotetramerization|protein heterotetramerization|oxidation-reduction process|NADPH binding|oxidoreductase complex CBS 12.3724238372771 13.116257993263 11.6285896812911 0.886578297504059 -0.17368004759565 0.920573631552819 1 0.1028 0.0560446 0.0717342 0.111181 GeneID:875,Genbank:XM_017028491.2,HGNC:HGNC:1550,MIM:613381 cystathionine-beta-synthase hsa00260,hsa00270 Glycine, serine and threonine metabolism|Cysteine and methionine metabolism CBSL 161.319494666784 121.075028247083 201.563961086486 1.66478557969152 0.735336373671204 0.232269346882021 1 0.764296 1.47397 1.5983 2.35848 GeneID:102724560,Genbank:XM_017028210.1,HGNC:HGNC:51829 cystathionine-beta-synthase like hsa00260,hsa00270 Glycine, serine and threonine metabolism|Cysteine and methionine metabolism CBWD1 228.829415235414 241.523680921552 216.135149549276 0.894881813346816 -0.160230936038249 0.474219072862181 1 2.06029 1.86809 1.83541 1.70566 GeneID:55871,Genbank:NM_001145356.1,HGNC:HGNC:17134,MIM:611078 COBW domain containing 1 GO:0005524 ATP binding CBWD2 289.683956431565 298.716939125654 280.650973737477 0.939521456529863 -0.0900019849974841 0.748011241954596 1 1.65607 2.11054 2.52319 1.26194 GeneID:150472,Genbank:NM_001330340.1,HGNC:HGNC:17907,MIM:611079 COBW domain containing 2 GO:0005524 ATP binding CBWD3 32.434965036788 19.3431073946539 45.5268226789222 2.35364575866983 1.23489720029661 0.436423020369697 1 0.115297 0.0934265 0.0371538 1.04846 GeneID:445571,Genbank:XM_006717116.1,HGNC:HGNC:18519,MIM:611080 COBW domain containing 3 GO:0005524 ATP binding CBWD5 144.60816169984 147.710354740449 141.50596865923 0.957996268493695 -0.0619080583790656 0.837465369826087 1 1.50395 1.45686 1.08765 1.33298 GeneID:220869,Genbank:XM_017014456.1,HGNC:HGNC:24584 COBW domain containing 5 GO:0005524 ATP binding CBWD6 29.295096463162 29.0288655742154 29.5613273521087 1.01834249349262 0.0262228566619104 0.973350650925971 1 0.233954 0.113568 0.201374 0.14014 GeneID:644019,Genbank:XM_017015028.1,HGNC:HGNC:31978 COBW domain containing 6 GO:0005524 ATP binding CBX1 3869.88829742824 3928.17340389269 3811.60319096378 0.970324575586865 -0.0434606823677441 0.762319991739455 1 47.4815 43.9489 46.4694 43.8716 GeneID:10951,Genbank:NM_001127228.1,HGNC:HGNC:1551,MIM:604511 chromobox 1 CBX2 480.515769345531 432.292675449348 528.738863241715 1.22310391378275 0.290546979115109 0.0997072882004004 1 2.66435 2.66094 3.58655 3.3605 GeneID:84733,Genbank:XM_011525383.2,HGNC:HGNC:1552,MIM:602770 chromobox 2 GO:0000122,GO:0000791,GO:0000792,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0006351,GO:0016569,GO:0030154,GO:0031519,GO:0035064,GO:0035102,GO:0045137 negative regulation of transcription from RNA polymerase II promoter|euchromatin|heterochromatin|DNA binding|chromatin binding|nucleus|nucleoplasm|transcription, DNA-templated|covalent chromatin modification|cell differentiation|PcG protein complex|methylated histone binding|PRC1 complex|development of primary sexual characteristics CBX3 3489.00141591171 3895.20028178918 3082.80255003423 0.791436210468286 -0.337455020645834 0.0435056703508025 0.780326589998453 54.3309 45.737 42.7109 37.309 GeneID:11335,Genbank:NM_007276.4,HGNC:HGNC:1553,MIM:604477 chromobox 3 GO:0000779,GO:0000785,GO:0005635,GO:0005719,GO:0005720,GO:0005819,GO:0006351,GO:0016569,GO:0019904,GO:0031618,GO:0042802,GO:0045892,GO:0048511,GO:1990226 condensed chromosome, centromeric region|chromatin|nuclear envelope|nuclear euchromatin|nuclear heterochromatin|spindle|transcription, DNA-templated|covalent chromatin modification|protein domain specific binding|nuclear pericentric heterochromatin|identical protein binding|negative regulation of transcription, DNA-templated|rhythmic process|histone methyltransferase binding CBX4 791.146022537068 741.935264242119 840.356780832018 1.13265512684646 0.179708653278732 0.259900232892253 1 7.42926 7.10024 8.71692 8.0028 GeneID:8535,Genbank:NM_003655.2,HGNC:HGNC:1554,MIM:603079 chromobox 4 GO:0000122,GO:0003682,GO:0003714,GO:0003727,GO:0005634,GO:0005654,GO:0006351,GO:0016569,GO:0016604,GO:0016607,GO:0016874,GO:0019789,GO:0019899,GO:0031519,GO:0032183,GO:0035064,GO:0035102,GO:0043066,GO:0044212,GO:0045892,GO:0051219 negative regulation of transcription from RNA polymerase II promoter|chromatin binding|transcription corepressor activity|single-stranded RNA binding|nucleus|nucleoplasm|transcription, DNA-templated|covalent chromatin modification|nuclear body|nuclear speck|ligase activity|SUMO transferase activity|enzyme binding|PcG protein complex|SUMO binding|methylated histone binding|PRC1 complex|negative regulation of apoptotic process|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|phosphoprotein binding CBX5 3421.0682799565 3600.40696488175 3241.72959503124 0.900378659037982 -0.15139623274761 0.563786745304817 1 13.8238 12.6059 14.6111 9.43497 GeneID:23468,Genbank:NM_012117.2,HGNC:HGNC:1555,MIM:604478 chromobox 5 GO:0000118,GO:0000122,GO:0000776,GO:0000784,GO:0003682,GO:0005634,GO:0005635,GO:0005654,GO:0005720,GO:0005721,GO:0005730,GO:0007596,GO:0010369,GO:0016032,GO:0017053,GO:0030674,GO:0031618,GO:0032991,GO:0035064,GO:0035097,GO:0042802,GO:0042803,GO:0042826,GO:0043021,GO:0044877,GO:0045892,GO:0070317,GO:0070491,GO:1990904 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|kinetochore|nuclear chromosome, telomeric region|chromatin binding|nucleus|nuclear envelope|nucleoplasm|nuclear heterochromatin|pericentric heterochromatin|nucleolus|blood coagulation|chromocenter|viral process|transcriptional repressor complex|protein binding, bridging|nuclear pericentric heterochromatin|macromolecular complex|methylated histone binding|histone methyltransferase complex|identical protein binding|protein homodimerization activity|histone deacetylase binding|ribonucleoprotein complex binding|macromolecular complex binding|negative regulation of transcription, DNA-templated|negative regulation of G0 to G1 transition|repressing transcription factor binding|ribonucleoprotein complex CBX6 2874.13185717947 2589.50031455849 3158.76339980045 1.21983510951572 0.286686145524778 0.0373591737741821 0.744556882325193 19.7956 20.2423 25.1171 24.7877 GeneID:23466,Genbank:NM_001303494.1,HGNC:HGNC:1556,MIM:617438 chromobox 6 GO:0000122,GO:0000792,GO:0003727,GO:0005634,GO:0005654,GO:0006351,GO:0016569,GO:0031519 negative regulation of transcription from RNA polymerase II promoter|heterochromatin|single-stranded RNA binding|nucleus|nucleoplasm|transcription, DNA-templated|covalent chromatin modification|PcG protein complex CBX7 330.76242771367 310.190495124521 351.33436030282 1.13264063801111 0.179690198319141 0.36582012722274 1 3.14922 3.36817 3.43728 3.98202 GeneID:23492,Genbank:NM_001346744.1,HGNC:HGNC:1557,MIM:608457 chromobox 7 GO:0000122,GO:0000790,GO:0000792,GO:0003006,GO:0003682,GO:0003727,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0016569,GO:0031519,GO:0032968,GO:0035064,GO:0035102,GO:0042493,GO:0048733 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|heterochromatin|developmental process involved in reproduction|chromatin binding|single-stranded RNA binding|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|covalent chromatin modification|PcG protein complex|positive regulation of transcription elongation from RNA polymerase II promoter|methylated histone binding|PRC1 complex|response to drug|sebaceous gland development CBX8 174.779453512889 181.41942027103 168.139486754748 0.926799823875294 -0.109670324847623 0.69851322373046 1 3.77179 4.24011 3.30651 4.08628 GeneID:57332,Genbank:NM_020649.2,HGNC:HGNC:15962,MIM:617354 chromobox 8 GO:0000122,GO:0000790,GO:0000792,GO:0003727,GO:0005634,GO:0005654,GO:0006351,GO:0008284,GO:0016574,GO:0031519,GO:0032967,GO:0035064,GO:0035102,GO:0045739,GO:0070301,GO:0097027 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|heterochromatin|single-stranded RNA binding|nucleus|nucleoplasm|transcription, DNA-templated|positive regulation of cell proliferation|histone ubiquitination|PcG protein complex|positive regulation of collagen biosynthetic process|methylated histone binding|PRC1 complex|positive regulation of DNA repair|cellular response to hydrogen peroxide|ubiquitin-protein transferase activator activity CBY1 378.690661863274 358.56246809339 398.818855633159 1.11227161547004 0.153509135581279 0.420833155513146 1 8.10647 9.11552 8.839 9.67227 GeneID:25776,Genbank:NM_001002880.1,HGNC:HGNC:1307,MIM:607757 chibby family member 1, beta catenin antagonist GO:0005634,GO:0005654,GO:0005802,GO:0005814,GO:0005829,GO:0008013,GO:0008104,GO:0016607,GO:0030030,GO:0030178,GO:0042802,GO:0042803,GO:0042995,GO:0045444,GO:0045892,GO:0051289,GO:0055007 nucleus|nucleoplasm|trans-Golgi network|centriole|cytosol|beta-catenin binding|protein localization|nuclear speck|cell projection organization|negative regulation of Wnt signaling pathway|identical protein binding|protein homodimerization activity|cell projection|fat cell differentiation|negative regulation of transcription, DNA-templated|protein homotetramerization|cardiac muscle cell differentiation CC2D1A 1581.95398758022 1590.37971884326 1573.52825631718 0.989404126369058 -0.015368178532364 0.887676538127267 1 13.0199 14.3925 13.7153 14.1792 GeneID:54862,Genbank:NM_017721.4,HGNC:HGNC:30237,MIM:610055 coiled-coil and C2 domain containing 1A GO:0000122,GO:0000978,GO:0000981,GO:0001078,GO:0001650,GO:0004871,GO:0005634,GO:0005815,GO:0005829,GO:0005886,GO:0006351,GO:0016020,GO:0043123,GO:0045296,GO:0070062 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|fibrillar center|signal transducer activity|nucleus|microtubule organizing center|cytosol|plasma membrane|transcription, DNA-templated|membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|cadherin binding|extracellular exosome CC2D1B 1666.70980547562 1657.60371080397 1675.81590014728 1.01098705874306 0.0157645299741534 0.933543994694719 1 4.92546 5.6789 5.50521 5.49868 GeneID:200014,Genbank:XM_005270590.2,HGNC:HGNC:29386 coiled-coil and C2 domain containing 1B GO:0000122,GO:0000978,GO:0000981,GO:0001078,GO:0005634,GO:0005654,GO:0006351,GO:0043231 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|intracellular membrane-bounded organelle CC2D2A 234.424956382711 233.788399694712 235.06151307071 1.00544557975357 0.00783499716355266 0.973456350920948 1 0.846623 0.779468 0.913249 0.715268 GeneID:57545,Genbank:XM_011513874.2,HGNC:HGNC:29253,MIM:612013 coiled-coil and C2 domain containing 2A GO:0001843,GO:0005829,GO:0005856,GO:0007224,GO:0007368,GO:0007507,GO:0035082,GO:0035869,GO:0036038,GO:0043010,GO:0044458,GO:0060271,GO:0097711,GO:1904491,GO:1905515,GO:1990403 neural tube closure|cytosol|cytoskeleton|smoothened signaling pathway|determination of left/right symmetry|heart development|axoneme assembly|ciliary transition zone|MKS complex|camera-type eye development|motile cilium assembly|cilium assembly|ciliary basal body-plasma membrane docking|protein localization to ciliary transition zone|non-motile cilium assembly|embryonic brain development CC2D2B 5.20373567214395 3.6226049124413 6.7848664318466 1.8729247587958 0.905292943204802 0.526582316392643 1 0 0 0.018673 0 GeneID:387707,Genbank:XM_024447997.1,HGNC:HGNC:31666 coiled-coil and C2 domain containing 2B CCAR1 643.658494450346 708.09970319599 579.217285704703 0.817988318721813 -0.289847853972712 0.366665287171326 1 4.82101 3.64337 4.10344 2.92812 GeneID:55749,Genbank:NM_001282959.1,HGNC:HGNC:24236,MIM:612569 cell division cycle and apoptosis regulator 1 GO:0000398,GO:0001047,GO:0003713,GO:0003714,GO:0003723,GO:0005654,GO:0006351,GO:0006355,GO:0006915,GO:0007049,GO:0008284,GO:0030335,GO:0030374,GO:0048471 mRNA splicing, via spliceosome|core promoter binding|transcription coactivator activity|transcription corepressor activity|RNA binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|cell cycle|positive regulation of cell proliferation|positive regulation of cell migration|ligand-dependent nuclear receptor transcription coactivator activity|perinuclear region of cytoplasm CCAR2 5148.59611564277 5139.44994138334 5157.7422899022 1.00355920355826 0.00512572896804498 0.982886332869907 1 46.2215 47.7251 47.6473 48.4548 GeneID:57805,Genbank:XM_011544603.2,HGNC:HGNC:23360,MIM:607359 cell cycle and apoptosis regulator 2 CCDC102A 258.324302432324 242.831215994008 273.81738887064 1.12760374628852 0.173260176159398 0.434060292135799 1 2.43049 2.83975 3.01442 3.0126 GeneID:92922,Genbank:XM_011523469.2,HGNC:HGNC:28097 coiled-coil domain containing 102A GO:0003774,GO:0016459 motor activity|myosin complex CCDC102B 31.6024388530439 29.278805602748 33.9260721033398 1.15872459292382 0.21253770556954 0.694675527389155 1 0.0638666 0.0556596 0.0700691 0.0482417 GeneID:79839,Genbank:XM_017025976.1,HGNC:HGNC:26295 coiled-coil domain containing 102B CCDC103 200.42622497416 180.333416262637 220.519033685682 1.22284065957315 0.290236427888157 0.207338706773152 1 2.77252 3.09943 3.65877 3.3215 GeneID:388389,Genbank:NM_001258399.1,HGNC:HGNC:32700,MIM:614677 coiled-coil domain containing 103 GO:0001947,GO:0003341,GO:0005737,GO:0005930,GO:0031514,GO:0036158,GO:0036159,GO:0042803,GO:0060287,GO:0070286,GO:0071907 heart looping|cilium movement|cytoplasm|axoneme|motile cilium|outer dynein arm assembly|inner dynein arm assembly|protein homodimerization activity|epithelial cilium movement involved in determination of left/right asymmetry|axonemal dynein complex assembly|determination of digestive tract left/right asymmetry CCDC106 1055.09942982284 1105.64838638361 1004.55047326206 0.908562329248067 -0.138342605180203 0.356142678873523 1 20.1201 19.5862 16.7329 19.904 GeneID:29903,Genbank:XM_024451477.1,HGNC:HGNC:30181,MIM:613478 coiled-coil domain containing 106 GO:0005634,GO:0005829 nucleus|cytosol CCDC107 932.388707128464 868.515730769463 996.261683487465 1.1470853643662 0.197972758542208 0.434332548963876 1 21.6502 23.9583 23.7813 30.4516 GeneID:203260,Genbank:NM_174923.2,HGNC:HGNC:28465 coiled-coil domain containing 107 GO:0016021 integral component of membrane CCDC110 1.75076843311023 1.07619535328461 2.42534151293585 2.25362570608911 1.17224792508914 0.75806356813066 1 0.0191046 0 0.0184733 0 GeneID:256309,Genbank:NM_001145411.1,HGNC:HGNC:28504,MIM:609488 coiled-coil domain containing 110 GO:0005634 nucleus CCDC112 69.9451151973776 68.637388237645 71.2528421571102 1.03810538230869 0.0539529049839005 0.877993490674501 1 0.767347 0.655396 0.725193 0.554939 GeneID:153733,Genbank:NM_001040440.2,HGNC:HGNC:28599 coiled-coil domain containing 112 CCDC113 230.177289157701 214.166943307056 246.187635008346 1.14951276423356 0.20102248588577 0.362462315871888 1 0.87106 0.93905 1.07433 1.03817 GeneID:29070,Genbank:XM_011523039.3,HGNC:HGNC:25002,MIM:616070 coiled-coil domain containing 113 GO:0005654,GO:0005829,GO:0034451,GO:0043234,GO:0060271 nucleoplasm|cytosol|centriolar satellite|protein complex|cilium assembly CCDC114 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0153376 0.00811733 0 GeneID:93233,Genbank:XM_011527515.2,HGNC:HGNC:26560,MIM:615038 coiled-coil domain containing 114 GO:0003341,GO:0005929,GO:0005930,GO:0036157,GO:0036158 cilium movement|cilium|axoneme|outer dynein arm|outer dynein arm assembly CCDC115 445.762190727905 478.675953845919 412.848427609891 0.862479981066236 -0.21343712396617 0.335035905125469 1 8.99078 9.35563 7.17515 9.18466 GeneID:84317,Genbank:NM_001321118.1,HGNC:HGNC:28178,MIM:613734 coiled-coil domain containing 115 GO:0005764,GO:0005768,GO:0005783,GO:0005793,GO:0006879,GO:0007042,GO:0016020,GO:0016471,GO:0030137,GO:0036295,GO:0042406,GO:0051082,GO:1905146 lysosome|endosome|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cellular iron ion homeostasis|lysosomal lumen acidification|membrane|vacuolar proton-transporting V-type ATPase complex|COPI-coated vesicle|cellular response to increased oxygen levels|extrinsic component of endoplasmic reticulum membrane|unfolded protein binding|lysosomal protein catabolic process CCDC116 6.03783186016167 5.77499561901052 6.30066810131283 1.09102560711421 0.12568496309427 0.972441566872773 1 0.0712158 0.020582 0.0658594 0.0616655 GeneID:164592,Genbank:XM_011529984.2,HGNC:HGNC:26688 coiled-coil domain containing 116 GO:0005737,GO:0005813 cytoplasm|centrosome CCDC117 530.575082842449 574.612244768267 486.537920916631 0.846723900067331 -0.240036482992272 0.166252773571863 1 6.40814 6.47038 5.26642 5.65547 GeneID:150275,Genbank:NM_173510.3,HGNC:HGNC:26599 coiled-coil domain containing 117 CCDC12 863.569495157141 905.75033166226 821.388658652021 0.906859903815419 -0.141048401555706 0.370345349521532 1 1.60145 1.49029 1.24503 1.53502 GeneID:151903,Genbank:XM_011533396.2,HGNC:HGNC:28332 coiled-coil domain containing 12 GO:0004814,GO:0005524,GO:0005737,GO:0006420 arginine-tRNA ligase activity|ATP binding|cytoplasm|arginyl-tRNA aminoacylation hsa03040 Spliceosome CCDC120 91.6216453081176 80.9852258359489 102.258064780286 1.26267555254374 0.336483982856268 0.281580045790668 1 0.787552 0.841619 1.17827 0.998782 GeneID:90060,Genbank:NM_001271836.1,HGNC:HGNC:28910,MIM:300947 coiled-coil domain containing 120 GO:0005768,GO:0005814,GO:0007275,GO:0008104,GO:0030426,GO:0034454,GO:0120103 endosome|centriole|multicellular organism development|protein localization|growth cone|microtubule anchoring at centrosome|centriolar subdistal appendage CCDC121 25.69587546994 26.194298366949 25.1974525729309 0.961944168915939 -0.0559749322491455 0.961388053685155 1 0.299027 0.260467 0.236677 0.336559 GeneID:79635,Genbank:XM_005264560.4,HGNC:HGNC:25833 coiled-coil domain containing 121 CCDC122 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0084424 0 0 0 GeneID:160857,Genbank:XM_017020399.1,HGNC:HGNC:26478,MIM:613408 coiled-coil domain containing 122 CCDC124 2379.58397268133 2335.73465724311 2423.43328811954 1.03754648697123 0.0531759774430699 0.743823525233189 1 65.2401 67.8473 66.2282 75.0393 GeneID:115098,Genbank:NM_001136203.1,HGNC:HGNC:25171 coiled-coil domain containing 124 GO:0003723,GO:0005815,GO:0005829,GO:0005886,GO:0007049,GO:0030496,GO:0051301 RNA binding|microtubule organizing center|cytosol|plasma membrane|cell cycle|midbody|cell division CCDC125 232.389285382222 236.536723007716 228.241847756727 0.964931976965292 -0.0515008519406671 0.823309501247916 1 1.29713 1.4884 1.30639 1.47568 GeneID:202243,Genbank:XM_011543258.2,HGNC:HGNC:28924,MIM:613781 coiled-coil domain containing 125 GO:0005737,GO:0035024,GO:0090630,GO:2000146 cytoplasm|negative regulation of Rho protein signal transduction|activation of GTPase activity|negative regulation of cell motility CCDC126 151.141973440431 163.670988596087 138.612958284775 0.846899988041556 -0.239736485749823 0.35626696730175 1 2.74766 2.56632 2.57426 2.08419 GeneID:90693,Genbank:NM_138771.3,HGNC:HGNC:22398 coiled-coil domain containing 126 GO:0005576,GO:0005794,GO:0006487,GO:0016020,GO:0030144 extracellular region|Golgi apparatus|protein N-linked glycosylation|membrane|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity CCDC127 449.474599561858 444.870835765969 454.078363357747 1.02069708070641 0.0295547712059471 0.872914843947406 1 13.5942 13.3564 13.6263 14.2187 GeneID:133957,Genbank:NM_145265.2,HGNC:HGNC:30520 coiled-coil domain containing 127 CCDC129 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.00405522 0.00411751 0 GeneID:223075,Genbank:NM_001257967.2,HGNC:HGNC:27363 coiled-coil domain containing 129 GO:0005102 receptor binding CCDC13 19.0443071516347 19.1892199154911 18.8993943877783 0.984896440345714 -0.0219560584952012 1 1 0.0264628 0.0236472 0.0318824 0.0364236 GeneID:152206,Genbank:XM_011533418.2,HGNC:HGNC:26358 coiled-coil domain containing 13 GO:0005634,GO:0005813,GO:0005829,GO:0006974,GO:0031122,GO:0034451,GO:0042995,GO:1905515 nucleus|centrosome|cytosol|cellular response to DNA damage stimulus|cytoplasmic microtubule organization|centriolar satellite|cell projection|non-motile cilium assembly CCDC130 581.559158293285 559.757232231238 603.361084355333 1.07789779142341 0.108220385142926 0.532981908765641 1 6.56494 7.0074 7.93188 7.30109 GeneID:81576,Genbank:NM_001320561.1,HGNC:HGNC:28118 coiled-coil domain containing 130 GO:0009615 response to virus CCDC134 550.355189611245 565.666498019195 535.043881203294 0.945864538693501 -0.0802945110569276 0.640086796924865 1 3.30635 3.27492 3.29651 2.98086 GeneID:79879,Genbank:XM_005261748.3,HGNC:HGNC:26185 coiled-coil domain containing 134 GO:0005576,GO:0005634,GO:0005783,GO:0016020 extracellular region|nucleus|endoplasmic reticulum|membrane CCDC136 273.046597420742 241.745211985615 304.347982855869 1.25896178193585 0.332234488101799 0.112596153114773 1 0.758633 0.854536 1.02473 1.10286 GeneID:64753,Genbank:XM_024446874.1,HGNC:HGNC:22225,MIM:611902 coiled-coil domain containing 136 GO:0001675,GO:0002080,GO:0007283,GO:0007338,GO:0016021 acrosome assembly|acrosomal membrane|spermatogenesis|single fertilization|integral component of membrane CCDC137 1583.01370095147 1594.50118681191 1571.52621509104 0.985591122847136 -0.0209388330530971 0.882159904424976 1 15.8865 17.4235 15.8256 17.7463 GeneID:339230,Genbank:XM_017024573.1,HGNC:HGNC:33451,MIM:614271 coiled-coil domain containing 137 GO:0001650,GO:0003723,GO:0005694,GO:0005730 fibrillar center|RNA binding|chromosome|nucleolus CCDC138 68.009736719924 70.1076024435171 65.9118709963309 0.940152974842257 -0.0890325741712307 0.836041455582795 1 0.400338 0.337698 0.368135 0.354991 GeneID:165055,Genbank:XM_024452737.1,HGNC:HGNC:26531 coiled-coil domain containing 138 CCDC14 483.901539912762 496.182220145728 471.620859679797 0.950499313621684 -0.0732425098177961 0.830860429639451 1 2.24225 1.91273 2.42685 1.58879 GeneID:64770,Genbank:XM_011513081.2,HGNC:HGNC:25766,MIM:617147 coiled-coil domain containing 14 GO:0005813,GO:0021762,GO:0034451,GO:0071539 centrosome|substantia nigra development|centriolar satellite|protein localization to centrosome CCDC141 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.00303396 0 GeneID:285025,Genbank:XM_011510993.3,HGNC:HGNC:26821,MIM:616031 coiled-coil domain containing 141 GO:0005737,GO:0005815 cytoplasm|microtubule organizing center CCDC142 205.07337467826 209.026097914058 201.120651442462 0.962179619911165 -0.0556218531106277 0.809305722869241 1 1.86174 1.91524 1.8924 1.79739 GeneID:84865,Genbank:NM_032779.3,HGNC:HGNC:25889 coiled-coil domain containing 142 CCDC144A 7.99528929875442 8.71542403075469 7.27515456675416 0.834744762972156 -0.260592957761356 0.883343741340534 1 0.0180003 0.0201015 0.0324061 0.00231639 GeneID:9720,Genbank:XM_024451045.1,HGNC:HGNC:29072 coiled-coil domain containing 144A CCDC146 15.5795937697538 14.682524748505 16.4766627910026 1.12219547204784 0.16632399679489 0.825249739576645 1 0.105436 0.0686434 0.0931814 0.125375 GeneID:57639,Genbank:NM_020879.2,HGNC:HGNC:29296 coiled-coil domain containing 146 GO:0005814 centriole CCDC148 4.05170730526154 5.67894306964064 2.42447154088245 0.426923022673632 -1.22795213000273 0.464586722259477 1 0.0103549 0.0203803 0.0201375 0.00931407 GeneID:130940,Genbank:XM_024452710.1,HGNC:HGNC:25191 coiled-coil domain containing 148 CCDC149 417.893728684247 424.797525595933 410.989931772561 0.967496058730565 -0.047672310696413 0.800312510222394 1 1.99519 1.94114 2.14128 1.76247 GeneID:91050,Genbank:XM_011513907.3,HGNC:HGNC:25405 coiled-coil domain containing 149 CCDC15 45.0334484239937 40.1466203400719 49.9202765079154 1.24344903967142 0.314347382729851 0.464755564252597 1 0.194462 0.173896 0.231613 0.190545 GeneID:80071,Genbank:NM_025004.2,HGNC:HGNC:25798 coiled-coil domain containing 15 GO:0005813 centrosome CCDC150 57.1084003721083 66.2350575025431 47.9817432416736 0.724416118153612 -0.465109448486653 0.238571405546045 1 0.234642 0.190626 0.152966 0.141893 GeneID:284992,Genbank:XM_006712438.3,HGNC:HGNC:26834 coiled-coil domain containing 150 CCDC151 69.0923226847444 63.0643063724822 75.1203389970066 1.19117046262773 0.252379885066205 0.481183708694885 1 0.510334 0.432955 0.638558 0.595837 GeneID:115948,Genbank:NM_001302453.1,HGNC:HGNC:28303,MIM:615956 coiled-coil domain containing 151 GO:0003341,GO:0005814,GO:0005929,GO:0005930,GO:0007368,GO:0036064,GO:0036158,GO:1902017 cilium movement|centriole|cilium|axoneme|determination of left/right symmetry|ciliary basal body|outer dynein arm assembly|regulation of cilium assembly CCDC152 6.89670279110017 8.46548400222204 5.32792157997829 0.629369989782015 -0.668019706567006 0.720128476737817 1 0.165323 0.0251632 0.0246873 0.103031 GeneID:100129792,Genbank:NM_001134848.1,HGNC:HGNC:34438 coiled-coil domain containing 152 CCDC153 7.28615353034415 8.27337890348227 6.29892815720603 0.761348927770588 -0.393370299512237 0.779487161372601 1 0.182642 0.216547 0.226696 0.158277 GeneID:283152,Genbank:NM_001145018.1,HGNC:HGNC:27446 coiled-coil domain containing 153 CCDC154 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0.0216579 GeneID:645811,Genbank:NM_001143980.1,HGNC:HGNC:34454 coiled-coil domain containing 154 GO:0005769 early endosome CCDC157 87.9741356803497 99.396216701373 76.5520546593263 0.770170708703331 -0.376749839594616 0.316069904847768 1 0.354014 0.363224 0.248053 0.436863 GeneID:550631,Genbank:NM_001318334.1,HGNC:HGNC:33854 coiled-coil domain containing 157 CCDC159 82.7656031522039 66.1870312278582 99.3441750765496 1.50096133991179 0.585886818107285 0.0647632072604163 0.901170744989424 1.16871 0.859767 1.40675 1.40123 GeneID:126075,Genbank:XM_017026260.2,HGNC:HGNC:26996 coiled-coil domain containing 159 CCDC160 24.4071309459441 26.0404108877863 22.7738510041019 0.874558051416289 -0.193373944347364 0.802352025513152 1 0.618494 0.326509 0.340008 0.464067 GeneID:347475,Genbank:NM_001353453.1,HGNC:HGNC:37286 coiled-coil domain containing 160 CCDC163 95.3290870733885 81.1293046600038 109.528869486773 1.35005310283117 0.43301615519052 0.154250555246338 1 1.75996 1.767 2.46857 2.13128 GeneID:126661,Genbank:NM_001358407.1,HGNC:HGNC:27003 coiled-coil domain containing 163 CCDC167 663.947300643275 636.379841724255 691.514759562295 1.08663837887865 0.11987190743211 0.472845482448287 1 35.0082 34.8679 34.7342 38.4033 GeneID:154467,Genbank:NM_138493.2,HGNC:HGNC:21239 coiled-coil domain containing 167 GO:0016021 integral component of membrane CCDC168 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00120163 0 GeneID:643677,Genbank:NM_001146197.2,HGNC:HGNC:26851 coiled-coil domain containing 168 CCDC169 7.50184637505857 7.24520982488261 7.75848292523453 1.07084309671601 0.0987471073779382 0.988763476354074 1 0.569693 0.287932 0.526873 0.493489 GeneID:728591,Genbank:NM_001144984.2,HGNC:HGNC:34361 coiled-coil domain containing 169 CCDC17 10.4015124072429 10.1376119619418 10.665412852544 1.05206363121646 0.0732219647673136 1 1 0.0434655 0.103004 0.0674161 0.0504836 GeneID:149483,Genbank:XM_017000451.1,HGNC:HGNC:26574 coiled-coil domain containing 17 CCDC170 1.24418854286568 1.51824048055703 0.97013660517434 0.638987444741564 -0.646140510486663 0.974454614671682 1 0.00667955 0.00642395 0.0128441 0 GeneID:80129,Genbank:NM_025059.3,HGNC:HGNC:21177 coiled-coil domain containing 170 CCDC171 18.5671784841295 20.6594341213632 16.4749228468958 0.797452764200336 -0.326529029141104 0.659764626653832 1 0.0432766 0.0362768 0.025047 0.0362672 GeneID:203238,Genbank:XM_005251397.2,HGNC:HGNC:29828 coiled-coil domain containing 171 CCDC173 5.09964802741179 7.29323609956755 2.90605995525603 0.398459602237249 -1.32749463066238 0.357816184255637 1 0 0 0 0.0117947 GeneID:129881,Genbank:NM_001085447.1,HGNC:HGNC:25064 coiled-coil domain containing 173 CCDC174 459.607828942817 490.350406597779 428.865251287855 0.874609759709328 -0.193288647445046 0.28250615336169 1 3.58264 3.74764 3.09204 3.42941 GeneID:51244,Genbank:NM_016474.4,HGNC:HGNC:28033,MIM:616735 coiled-coil domain containing 174 GO:0005634,GO:0005654 nucleus|nucleoplasm CCDC175 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0 0 0 0 GeneID:729665,Genbank:NM_001164399.1,HGNC:HGNC:19847 coiled-coil domain containing 175 CCDC18 69.8966299156859 63.1985765414291 76.5946832899428 1.21196848855816 0.277352188916577 0.63721262504501 1 0.178373 0.0838269 0.214894 0.09689 GeneID:343099,Genbank:XM_017001164.2,HGNC:HGNC:30370 coiled-coil domain containing 18 CCDC180 47.8990951200952 41.0307105946168 54.7674796455736 1.33479237507427 0.416615350342822 0.320334804121307 1 0.115914 0.135014 0.191306 0.132805 GeneID:100499483,Genbank:NM_001348010.1,HGNC:HGNC:29303 coiled-coil domain containing 180 GO:0016021,GO:0070062 integral component of membrane|extracellular exosome CCDC181 31.3473384202194 42.3470373213261 20.3476395191126 0.480497357222804 -1.05739959881454 0.040200312885562 0.758464027333929 0.270715 0.246461 0.0690786 0.199647 GeneID:57821,Genbank:XM_017001938.1,HGNC:HGNC:28051 coiled-coil domain containing 181 GO:0002177,GO:0005737,GO:0005874,GO:0008017,GO:0036126 manchette|cytoplasm|microtubule|microtubule binding|sperm flagellum CCDC183 12.9769157022586 12.8761266198383 13.0777047846789 1.01565518659392 0.0224106924398175 1 1 0.0423057 0.0939704 0.0392068 0.0728568 GeneID:84960,Genbank:NM_001039374.4,HGNC:HGNC:28236,MIM:615955 coiled-coil domain containing 183 GO:0003341,GO:0005930,GO:0036158 cilium movement|axoneme|outer dynein arm assembly CCDC184 42.888549460285 32.4691740430248 53.3079248775451 1.64180107590377 0.715279337717178 0.109999038838458 1 0.549621 0.854302 1.1739 1.17922 GeneID:387856,Genbank:NM_001013635.3,HGNC:HGNC:33749 coiled-coil domain containing 184 GO:0005737 cytoplasm CCDC186 65.306716567307 56.9335095204612 73.6799236141528 1.29413985251819 0.371993532038394 0.416077087748585 1 0.257479 0.188516 0.365692 0.208879 GeneID:55088,Genbank:XM_011539915.3,HGNC:HGNC:24349 coiled-coil domain containing 186 CCDC187 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00821438 0 0 GeneID:399693,Genbank:XM_011518679.2,HGNC:HGNC:30942 coiled-coil domain containing 187 GO:0005813,GO:0008017,GO:0034453 centrosome|microtubule binding|microtubule anchoring CCDC188 26.8041319621241 29.3748581521179 24.2334057721304 0.82497098868146 -0.277584709130503 0.643668847046321 1 0.331434 0.22918 0.307857 0.197138 GeneID:388849,Genbank:XM_005261239.3,HGNC:HGNC:51899 coiled-coil domain containing 188 GO:0016021 integral component of membrane CCDC189 177.376426303464 195.323715969468 159.429136637461 0.816230306935089 -0.292951815493004 0.212451378154711 1 1.82799 1.73494 1.65233 1.61994 GeneID:90835,Genbank:XM_017023858.2,HGNC:HGNC:28078 coiled-coil domain containing 189 CCDC190 1.02316597922947 1.07619535328461 0.97013660517434 0.901450282435646 -0.149680169798226 1 1 0.0111196 0 0.0106729 0 GeneID:339512,Genbank:XM_006711289.3,HGNC:HGNC:28736 coiled-coil domain containing 190 CCDC191 9.55350805243931 10.8678147373239 8.23920136755471 0.758128618006193 -0.399485469685195 0.723210804495509 1 0.0373201 0.03588 0.0314572 0.0250743 GeneID:57577,Genbank:NM_001353767.2,HGNC:HGNC:29272 coiled-coil domain containing 191 CCDC192 0.968831647094244 0 1.93766329418849 Inf Inf 0.451925900856321 1 0 0 0 0 GeneID:728586,Genbank:XM_017009806.2,HGNC:HGNC:49566 coiled-coil domain containing 192 CCDC194 2.96594073926325 1.56626675524197 4.36561472328453 2.78727407619023 1.47885487144758 0.626561469903103 1 0 0 0.184031 0 GeneID:110806280,Genbank:XM_011528476.3,HGNC:HGNC:53438 coiled-coil domain containing 194 CCDC198 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.00867462 0 0.00808052 GeneID:55195,Genbank:NM_001283059.1,HGNC:HGNC:20189 coiled-coil domain containing 198 CCDC22 328.978226507277 309.037864532082 348.918588482471 1.12904801814746 0.175106844897505 0.394871366009254 1 4.82327 6.40356 6.18853 6.62017 GeneID:28952,Genbank:NM_014008.4,HGNC:HGNC:28909,MIM:300859 coiled-coil domain containing 22 GO:0005654,GO:0005768,GO:0005829,GO:0006878,GO:0006893,GO:0007253,GO:0015031,GO:0016567,GO:0043123,GO:0043124,GO:0043687,GO:0097602,GO:2000060 nucleoplasm|endosome|cytosol|cellular copper ion homeostasis|Golgi to plasma membrane transport|cytoplasmic sequestering of NF-kappaB|protein transport|protein ubiquitination|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|post-translational protein modification|cullin family protein binding|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process CCDC24 75.153331325834 72.7696818622595 77.5369807894084 1.06551215843121 0.0915470556342989 0.831173183660587 1 0.791256 1.11452 1.05176 1.15797 GeneID:149473,Genbank:XM_017000424.1,HGNC:HGNC:28688 coiled-coil domain containing 24 CCDC25 829.153712161444 803.864523330668 854.44290099222 1.06291903199309 0.0880317035566769 0.557769021349413 1 8.12353 7.52879 9.04871 7.84249 GeneID:55246,Genbank:NM_001304530.1,HGNC:HGNC:25591 coiled-coil domain containing 25 GO:0070062 extracellular exosome CCDC28A 289.130041058117 283.102297847919 295.157784268315 1.04258349901092 0.0601629316651111 0.775020267833375 1 4.24813 4.54961 5.01618 4.24457 GeneID:25901,Genbank:XM_011535728.3,HGNC:HGNC:21098,MIM:615353 coiled-coil domain containing 28A CCDC28B 293.054786265007 281.286091064144 304.823481465869 1.08367776135919 0.115935825694023 0.566579827101886 1 1.66489 1.65571 2.04981 1.88492 GeneID:79140,Genbank:NM_001301011.1,HGNC:HGNC:28163,MIM:610162 coiled-coil domain containing 28B GO:0005737,GO:0005813,GO:0060271 cytoplasm|centrosome|cilium assembly CCDC3 38.6375022850841 45.2874657330703 31.9875388370979 0.706322120686467 -0.501601815170242 0.283136318015252 1 0.562417 0.464699 0.372842 0.348848 GeneID:83643,Genbank:NM_001282658.1,HGNC:HGNC:23813 coiled-coil domain containing 3 GO:0005576,GO:0005783,GO:0010804,GO:0045600,GO:0046889 extracellular region|endoplasmic reticulum|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of fat cell differentiation|positive regulation of lipid biosynthetic process CCDC30 11.6981869716619 13.2221191977408 10.174254745583 0.769487447013895 -0.378030303458659 0.677485877487293 1 0.0319527 0.0342727 0.0152746 0.0426633 GeneID:728621,Genbank:NM_001355226.1,HGNC:HGNC:26103 coiled-coil domain containing 30 GO:0070062 extracellular exosome CCDC32 347.355916162179 285.706542336868 409.005289987489 1.4315573127662 0.517585430161505 0.00724915816779429 0.338869203906778 2.6881 2.90116 4.33908 4.37376 GeneID:90416,Genbank:NM_001289132.1,HGNC:HGNC:28295 coiled-coil domain containing 32 CCDC33 7.24900342645299 10.1376119619418 4.36039489096415 0.430120516284678 -1.21718714696626 0.274839710576123 1 0.00509124 0.013594 0.00950635 0.0133524 GeneID:80125,Genbank:XM_017022633.1,HGNC:HGNC:26552 coiled-coil domain containing 33 CCDC34 352.810251099827 330.542154287558 375.078347912096 1.13473680450994 0.182357711735814 0.338768895643544 1 4.19999 4.3922 4.56138 5.30471 GeneID:91057,Genbank:NM_030771.1,HGNC:HGNC:25079,MIM:612324 coiled-coil domain containing 34 CCDC38 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0 0 0 0.00985081 GeneID:120935,Genbank:NM_182496.2,HGNC:HGNC:26843 coiled-coil domain containing 38 GO:0005737,GO:0005813 cytoplasm|centrosome CCDC39 2.09936133251408 3.22858605985383 0.97013660517434 0.300483427478549 -1.73464267051938 0.65312594605688 1 0.0325887 0 0.0158602 0 GeneID:339829,Genbank:NM_181426.1,HGNC:HGNC:25244,MIM:613798 coiled-coil domain containing 39 GO:0001947,GO:0003341,GO:0003356,GO:0005930,GO:0030317,GO:0030324,GO:0035469,GO:0036159,GO:0044458,GO:0060285,GO:0060287,GO:0070286,GO:0071907,GO:0071910 heart looping|cilium movement|regulation of cilium beat frequency|axoneme|flagellated sperm motility|lung development|determination of pancreatic left/right asymmetry|inner dynein arm assembly|motile cilium assembly|cilium-dependent cell motility|epithelial cilium movement involved in determination of left/right asymmetry|axonemal dynein complex assembly|determination of digestive tract left/right asymmetry|determination of liver left/right asymmetry CCDC40 55.3583533058657 49.1600106740442 61.5566959376872 1.25217010927518 0.324430567970931 0.413793490906917 1 0.152743 0.13157 0.247525 0.121481 GeneID:55036,Genbank:NM_017950.3,HGNC:HGNC:26090,MIM:613799 coiled-coil domain containing 40 CCDC42 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0236886 GeneID:146849,Genbank:NM_001158261.1,HGNC:HGNC:26528 coiled-coil domain containing 42 GO:0007286 spermatid development CCDC43 694.937437058204 712.857355392363 677.017518724044 0.949723691006046 -0.0744202525991438 0.66791462802878 1 11.7435 10.7846 11.3267 10.7358 GeneID:124808,Genbank:NM_001099225.1,HGNC:HGNC:26472 coiled-coil domain containing 43 GO:0005829 cytosol CCDC47 2683.3151314859 2746.03566118415 2620.59460178766 0.954319216909804 -0.0674561707731806 0.722507154567275 1 26.6781 23.9287 27.2432 21.5799 GeneID:57003,Genbank:NM_020198.2,HGNC:HGNC:24856 coiled-coil domain containing 47 GO:0001649,GO:0003723,GO:0005509,GO:0005783,GO:0005791,GO:0006983,GO:0007029,GO:0009791,GO:0016020,GO:0016021,GO:0030433,GO:0055074 osteoblast differentiation|RNA binding|calcium ion binding|endoplasmic reticulum|rough endoplasmic reticulum|ER overload response|endoplasmic reticulum organization|post-embryonic development|membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|calcium ion homeostasis CCDC50 3041.36177260746 3103.66906375088 2979.05448146405 0.959849268808244 -0.0591202267790389 0.673515299653503 1 13.3994 13.526 13.3222 12.3588 GeneID:152137,Genbank:XM_011512460.1,HGNC:HGNC:18111,MIM:611051 coiled-coil domain containing 50 GO:0005829,GO:0007605,GO:0031625 cytosol|sensory perception of sound|ubiquitin protein ligase binding CCDC51 544.820181875826 553.195215907907 536.445147843745 0.969721234778447 -0.0443580187251442 0.821869354685858 1 6.58223 8.40848 6.56183 7.96227 GeneID:79714,Genbank:XM_011534113.2,HGNC:HGNC:25714 coiled-coil domain containing 51 GO:0005739,GO:0016021 mitochondrion|integral component of membrane CCDC54 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:84692,Genbank:NM_032600.2,HGNC:HGNC:30703 coiled-coil domain containing 54 CCDC57 490.366134765051 497.567207458192 483.165062071909 0.971054874255367 -0.0423752703250869 0.807612271219189 1 0.964858 0.898035 0.857973 0.913695 GeneID:284001,Genbank:NM_198082.3,HGNC:HGNC:27564 coiled-coil domain containing 57 CCDC58 205.667043517353 228.157482899756 183.17660413495 0.802851617255225 -0.316794720882119 0.165114680474843 1 3.78157 3.32216 2.61744 2.56404 GeneID:131076,Genbank:XM_011512410.2,HGNC:HGNC:31136 coiled-coil domain containing 58 GO:0005739 mitochondrion CCDC59 324.632013312439 353.180474326112 296.083552298766 0.838334998172563 -0.254401235657055 0.263072566836408 1 7.76384 6.4849 5.66623 6.19623 GeneID:29080,Genbank:NM_014167.4,HGNC:HGNC:25005 coiled-coil domain containing 59 GO:0003723,GO:0005654,GO:0006351,GO:0006355,GO:0044267 RNA binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular protein metabolic process CCDC6 1046.72568734985 1065.89476789528 1027.55660680442 0.964031945511323 -0.0528471404786564 0.807701902894476 1 7.97332 7.73482 9.06223 6.36638 GeneID:8030,Genbank:NM_005436.4,HGNC:HGNC:18782,MIM:601985 coiled-coil domain containing 6 hsa05200,hsa05216 Pathways in cancer|Thyroid cancer CCDC61 226.47676216715 207.257917404968 245.695606929331 1.18545824451791 0.245444847562345 0.26308493848666 1 1.47685 1.41223 1.69396 1.86936 GeneID:729440,Genbank:XM_011527257.2,HGNC:HGNC:33629 coiled-coil domain containing 61 GO:0005813 centrosome CCDC62 6.75686546083723 8.66739775606975 4.84633316560471 0.559145120830626 -0.838705325359226 0.484803471152606 1 0.0454922 0.0172629 0.0435143 0.024314 GeneID:84660,Genbank:XM_017020033.2,HGNC:HGNC:30723,MIM:613481 coiled-coil domain containing 62 GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0030331,GO:0030374,GO:0045944,GO:0071392 nucleus|nucleoplasm|cytoplasm|plasma membrane|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|positive regulation of transcription from RNA polymerase II promoter|cellular response to estradiol stimulus CCDC63 6.97408151670825 8.61937148138481 5.32879155203169 0.618234353112665 -0.693774272965104 0.558257626009888 1 0.0330561 0.0905293 0.0103927 0.0580685 GeneID:160762,Genbank:XM_011538001.2,HGNC:HGNC:26669 coiled-coil domain containing 63 GO:0003341,GO:0005930,GO:0007286,GO:0036158 cilium movement|axoneme|spermatid development|outer dynein arm assembly CCDC65 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:85478,Genbank:NM_033124.4,HGNC:HGNC:29937,MIM:611088 coiled-coil domain containing 65 GO:0003352,GO:0060271 regulation of cilium movement|cilium assembly CCDC66 74.2724964233033 77.7850487405642 70.7599441060424 0.909685669055084 -0.136559969393968 0.757684894351586 1 0.364792 0.265856 0.346536 0.270611 GeneID:285331,Genbank:XM_011533615.2,HGNC:HGNC:27709 coiled-coil domain containing 66 CCDC69 70.6672906806466 68.1571254907956 73.1774558704977 1.07365818824592 0.102534767428455 0.78837061350128 1 0.677896 0.713449 0.784717 0.752728 GeneID:26112,Genbank:NM_015621.2,HGNC:HGNC:24487 coiled-coil domain containing 69 GO:0005737,GO:0030496,GO:0051233,GO:0051255 cytoplasm|midbody|spindle midzone|spindle midzone assembly CCDC7 9.06853521013243 5.53486424558581 12.6022061746791 2.27687719436473 1.18705648038149 0.24448135412311 1 0.00846082 0.0204274 0.0407778 0.0265195 GeneID:79741,Genbank:NM_001321115.1,HGNC:HGNC:26533 coiled-coil domain containing 7 CCDC70 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.029311 0 0 0 GeneID:83446,Genbank:NM_001346075.1,HGNC:HGNC:25303 coiled-coil domain containing 70 GO:0005576,GO:0005886 extracellular region|plasma membrane CCDC71 660.34029490328 640.310221595022 680.370368211538 1.06256365315663 0.0875492688670346 0.610198631454889 1 14.5439 15.3537 15.109 17.2156 GeneID:64925,Genbank:NM_022903.3,HGNC:HGNC:25760 coiled-coil domain containing 71 CCDC71L 394.655810062146 397.258491537806 392.053128586487 0.986896786192868 -0.0190288854174813 0.904535936754954 1 2.80683 3.46854 3.0757 3.13212 GeneID:168455,Genbank:NM_175884.5,HGNC:HGNC:26685 coiled-coil domain containing 71 like GO:0044255,GO:0045600 cellular lipid metabolic process|positive regulation of fat cell differentiation CCDC73 93.9426704320992 109.879821241217 78.0055196229811 0.709916695730118 -0.494278351549069 0.19137108983761 1 0.111622 0.0882894 0.0624415 0.0722853 GeneID:493860,Genbank:NM_001008391.3,HGNC:HGNC:23261,MIM:612328 coiled-coil domain containing 73 CCDC74A 78.8284936991289 70.9054488038 86.7515385944579 1.22348197575768 0.290992847901522 0.397790241906914 1 0.42279 0.809472 0.919372 0.761516 GeneID:90557,Genbank:XM_017005241.1,HGNC:HGNC:25197 coiled-coil domain containing 74A CCDC74B 30.5872983745178 25.8002795143615 35.3743172346741 1.37108271307616 0.455315606963477 0.37608928615141 1 0.368958 0.224891 0.290405 0.367336 GeneID:91409,Genbank:NM_001258307.1,HGNC:HGNC:25267 coiled-coil domain containing 74B CCDC77 282.675502250346 302.657127651528 262.693876849164 0.867958666255575 -0.204301754300524 0.305586390948079 1 3.18819 3.78566 3.46585 2.67343 GeneID:84318,Genbank:NM_001130147.1,HGNC:HGNC:28203 coiled-coil domain containing 77 GO:0005813,GO:0016020 centrosome|membrane CCDC78 17.3835335590331 20.2271976491987 14.5398694688675 0.71882767554029 -0.476282139856842 0.483581362399432 1 0.0400308 0.0571371 0.0491337 0.10352 GeneID:124093,Genbank:XM_017022929.1,HGNC:HGNC:14153,MIM:614666 coiled-coil domain containing 78 GO:0003009,GO:0005814,GO:0016529,GO:0030030,GO:0042383,GO:0048471,GO:0098535,GO:0098536 skeletal muscle contraction|centriole|sarcoplasmic reticulum|cell projection organization|sarcolemma|perinuclear region of cytoplasm|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation|deuterosome CCDC8 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0373788 0 GeneID:83987,Genbank:NM_032040.4,HGNC:HGNC:25367,MIM:614145 coiled-coil domain containing 8 GO:0000226,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0007088,GO:0010923,GO:0043687,GO:1990393 microtubule cytoskeleton organization|nucleus|cytoplasm|centrosome|cytosol|plasma membrane|regulation of mitotic nuclear division|negative regulation of phosphatase activity|post-translational protein modification|3M complex CCDC80 1075.50601762165 910.247218174138 1240.76481706916 1.36310750782409 0.446899351496116 0.00474689161499607 0.274462874028076 5.45216 5.24457 8.25 6.31427 GeneID:151887,Genbank:NM_199512.2,HGNC:HGNC:30649,MIM:608298 coiled-coil domain containing 80 GO:0001968,GO:0005604,GO:0005614,GO:0005615,GO:0008201,GO:0010811,GO:0030198 fibronectin binding|basement membrane|interstitial matrix|extracellular space|heparin binding|positive regulation of cell-substrate adhesion|extracellular matrix organization CCDC81 3.2391227049012 3.084507235799 3.3937381740034 1.10025294627791 0.137835235013391 1 1 0.00871406 0.00827054 0.033438 0.0155437 GeneID:60494,Genbank:NM_001156474.1,HGNC:HGNC:26281 coiled-coil domain containing 81 GO:0003677,GO:0005737,GO:0005813 DNA binding|cytoplasm|centrosome CCDC82 150.228322076545 159.404424802525 141.052219350566 0.884870162953789 -0.17646231088315 0.606950571144248 1 0.576645 0.4752 0.543418 0.329907 GeneID:79780,Genbank:XM_017018310.1,HGNC:HGNC:26282 coiled-coil domain containing 82 CCDC84 148.029620747135 147.278118268285 148.781123225985 1.01020521565167 0.014648395481408 0.967136399048858 1 2.14526 2.10764 2.58953 1.93324 GeneID:338657,Genbank:NM_198489.2,HGNC:HGNC:30460 coiled-coil domain containing 84 CCDC85A 14.6482484407612 11.8479575412386 17.4485393402838 1.47270441167192 0.558467894319294 0.469960705084768 1 0.134761 0.0820479 0.212009 0.148073 GeneID:114800,Genbank:NM_001348512.1,HGNC:HGNC:29400 coiled-coil domain containing 85A CCDC85B 1356.13100449136 1211.91642836835 1500.34558061436 1.23799425892289 0.30800462421076 0.0391000410090739 0.753859521009372 80.3941 86.1115 105.942 110.615 GeneID:11007,Genbank:NM_006848.2,HGNC:HGNC:24926,MIM:605360 coiled-coil domain containing 85B GO:0005634,GO:0005737,GO:0005813,GO:0006351,GO:0030154,GO:0030308,GO:0045599,GO:0045892 nucleus|cytoplasm|centrosome|transcription, DNA-templated|cell differentiation|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated CCDC85C 886.774097191217 823.209664727032 950.338529655402 1.15443072448685 0.207181601922819 0.193615000001109 1 4.18531 4.66996 5.04365 5.16824 GeneID:317762,Genbank:NM_001144995.1,HGNC:HGNC:35459 coiled-coil domain containing 85C GO:0005923,GO:0021987,GO:0043296 bicellular tight junction|cerebral cortex development|apical junction complex CCDC86 2233.51639608446 2372.42236880501 2094.61042336391 0.882899457915227 -0.179678937677063 0.189893923157291 1 41.0508 42.7364 39.5025 35.9108 GeneID:79080,Genbank:NM_024098.3,HGNC:HGNC:28359,MIM:611293 coiled-coil domain containing 86 GO:0003723,GO:0005634,GO:0005730,GO:0016032 RNA binding|nucleus|nucleolus|viral process CCDC87 9.31097390114573 10.8678147373239 7.75413306496754 0.713495146207923 -0.487024479573959 0.656461634225572 1 0.175919 0.117998 0.109799 0.102622 GeneID:55231,Genbank:NM_018219.2,HGNC:HGNC:25579 coiled-coil domain containing 87 CCDC88A 125.449856436296 127.281243337403 123.61846953519 0.971222988508181 -0.0421255248029921 0.965114267959331 1 0.392026 0.290595 0.430989 0.186636 GeneID:55704,Genbank:XM_011532967.3,HGNC:HGNC:25523,MIM:609736 coiled-coil domain containing 88A GO:0001932,GO:0003779,GO:0005783,GO:0005794,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0006260,GO:0006275,GO:0008017,GO:0010975,GO:0016020,GO:0016477,GO:0030027,GO:0030032,GO:0030705,GO:0031122,GO:0031410,GO:0031929,GO:0032148,GO:0032956,GO:0035091,GO:0036064,GO:0042127,GO:0042803,GO:0043422,GO:0045724,GO:0051959,GO:0061024,GO:1903566 regulation of protein phosphorylation|actin binding|endoplasmic reticulum|Golgi apparatus|centrosome|centriole|cytosol|plasma membrane|DNA replication|regulation of DNA replication|microtubule binding|regulation of neuron projection development|membrane|cell migration|lamellipodium|lamellipodium assembly|cytoskeleton-dependent intracellular transport|cytoplasmic microtubule organization|cytoplasmic vesicle|TOR signaling|activation of protein kinase B activity|regulation of actin cytoskeleton organization|phosphatidylinositol binding|ciliary basal body|regulation of cell proliferation|protein homodimerization activity|protein kinase B binding|positive regulation of cilium assembly|dynein light intermediate chain binding|membrane organization|positive regulation of protein localization to cilium CCDC88B 104.059386223389 92.3048943556532 115.813878091125 1.25468837703114 0.327329091078692 0.279608135107872 1 0.557588 0.709463 0.747804 0.794144 GeneID:283234,Genbank:XM_024448450.1,HGNC:HGNC:26757,MIM:611205 coiled-coil domain containing 88B GO:0001819,GO:0005737,GO:0005783,GO:0005794,GO:0005813,GO:0008017,GO:0016020,GO:0030705,GO:0031122,GO:0042102,GO:0042832,GO:0050870,GO:0051959 positive regulation of cytokine production|cytoplasm|endoplasmic reticulum|Golgi apparatus|centrosome|microtubule binding|membrane|cytoskeleton-dependent intracellular transport|cytoplasmic microtubule organization|positive regulation of T cell proliferation|defense response to protozoan|positive regulation of T cell activation|dynein light intermediate chain binding CCDC88C 89.7025441596798 75.2102302169384 104.194858102421 1.38538145411706 0.470283265944212 0.135820108018025 1 0.252137 0.297771 0.365152 0.3699 GeneID:440193,Genbank:NM_001080414.3,HGNC:HGNC:19967,MIM:611204 coiled-coil domain containing 88C GO:0001932,GO:0005737,GO:0005813,GO:0008017,GO:0016055,GO:0030165,GO:0030705,GO:0031098,GO:0031122,GO:0031648,GO:0043621,GO:0051260,GO:0051959 regulation of protein phosphorylation|cytoplasm|centrosome|microtubule binding|Wnt signaling pathway|PDZ domain binding|cytoskeleton-dependent intracellular transport|stress-activated protein kinase signaling cascade|cytoplasmic microtubule organization|protein destabilization|protein self-association|protein homooligomerization|dynein light intermediate chain binding CCDC89 20.9679860080748 24.4839527876522 17.4520192284974 0.712794187272685 -0.488442522936429 0.436547356973976 1 0.390799 0.515627 0.447165 0.208077 GeneID:220388,Genbank:NM_152723.2,HGNC:HGNC:26762 coiled-coil domain containing 89 GO:0005634,GO:0005737 nucleus|cytoplasm CCDC9 487.77974514292 435.185077586407 540.374412699433 1.24171172342678 0.31233027544559 0.0762346698665439 0.94157495521624 5.33582 5.3166 7.47575 6.57979 GeneID:26093,Genbank:NM_015603.2,HGNC:HGNC:24560 coiled-coil domain containing 9 GO:0003723 RNA binding CCDC90B 498.066242719526 504.244893641109 491.887591797944 0.975493451695794 -0.0357959065612229 0.856905873809533 1 3.93482 3.51547 3.8995 3.77929 GeneID:60492,Genbank:NM_001286116.1,HGNC:HGNC:28108 coiled-coil domain containing 90B GO:0005739,GO:0016021,GO:0031966 mitochondrion|integral component of membrane|mitochondrial membrane CCDC91 99.938086105499 111.176530657711 88.6996415532871 0.797827032634924 -0.325852088048364 0.360891699903094 1 1.29139 1.06056 0.944624 0.864538 GeneID:55297,Genbank:NM_001352086.1,HGNC:HGNC:24855,MIM:617366 coiled-coil domain containing 91 GO:0005802,GO:0005829,GO:0015031,GO:0016020,GO:0090160 trans-Golgi network|cytosol|protein transport|membrane|Golgi to lysosome transport CCDC92 606.557401593886 524.933753727796 688.181049459976 1.31098647128878 0.390652797760053 0.0197381069860708 0.574202218891059 4.90544 4.82591 6.67698 6.22643 GeneID:80212,Genbank:NM_001304961.1,HGNC:HGNC:29563 coiled-coil domain containing 92 GO:0005654,GO:0005813,GO:0005814,GO:0043231 nucleoplasm|centrosome|centriole|intracellular membrane-bounded organelle CCDC92B 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00882783 GeneID:101928991,Genbank:NM_001355573.1,HGNC:HGNC:52279 coiled-coil domain containing 92B GO:0005829,GO:0016020,GO:0042803,GO:0070062 cytosol|membrane|protein homodimerization activity|extracellular exosome CCDC93 672.066902697817 697.080034981213 647.053770414421 0.928234546886514 -0.107438702384257 0.51786821226652 1 2.55185 2.60736 2.83047 2.067 GeneID:54520,Genbank:NM_019044.4,HGNC:HGNC:25611 coiled-coil domain containing 93 GO:0005769,GO:0006893,GO:0015031,GO:0043231 early endosome|Golgi to plasma membrane transport|protein transport|intracellular membrane-bounded organelle CCDC96 32.6204075008067 33.7374744950492 31.5033405065641 0.933778860986974 -0.0988471658644021 0.864060070425434 1 0.545451 0.60757 0.636123 0.490745 GeneID:257236,Genbank:NM_153376.2,HGNC:HGNC:26900 coiled-coil domain containing 96 GO:0005737,GO:0005815 cytoplasm|microtubule organizing center CCDC97 1115.98412504448 1123.66535839645 1108.30289169251 0.986328254591865 -0.0198602328077684 0.889454450169169 1 7.59536 7.74234 7.39559 7.87598 GeneID:90324,Genbank:XM_017027442.1,HGNC:HGNC:28289 coiled-coil domain containing 97 GO:0005686 U2 snRNP CCDC9B 3263.06598035391 3288.31808708261 3237.8138736252 0.98464132358247 -0.022329806790846 0.870948104364398 1 21.9956 21.4392 22.3689 21.0162 GeneID:388115,Genbank:NM_207380.2,HGNC:HGNC:33488 coiled-coil domain containing 9B GO:0003723 RNA binding CCER2 26.9777685839838 25.8581144441544 28.0974227238132 1.08659982863387 0.119820724596486 0.920775947160166 1 0.179099 0.18088 0.15533 0.313146 GeneID:643669,Genbank:XM_011527219.3,HGNC:HGNC:44662,MIM:617634 coiled-coil glutamate rich protein 2 GO:0005576 extracellular region CCHCR1 899.489411419947 852.114068787408 946.864754052486 1.1111948373296 0.152111801609509 0.523838074912084 1 6.78915 7.74192 7.44744 8.87452 GeneID:54535,Genbank:NM_019052.3,HGNC:HGNC:13930,MIM:605310 coiled-coil alpha-helical rod protein 1 GO:0005634,GO:0005814,GO:0005829,GO:0006611,GO:0007275,GO:0030154,GO:0042802 nucleus|centriole|cytosol|protein export from nucleus|multicellular organism development|cell differentiation|identical protein binding CCIN 50.7026260488241 53.9068372144551 47.4984148831932 0.881120416956247 -0.182588898585997 0.66952544719409 1 1.02005 1.01211 1.02064 0.827471 GeneID:881,Genbank:NM_005893.2,HGNC:HGNC:1568,MIM:603960 calicin GO:0003779,GO:0005634,GO:0007275,GO:0007283,GO:0015629,GO:0030154,GO:0031463,GO:0033150,GO:0042787 actin binding|nucleus|multicellular organism development|spermatogenesis|actin cytoskeleton|cell differentiation|Cul3-RING ubiquitin ligase complex|cytoskeletal calyx|protein ubiquitination involved in ubiquitin-dependent protein catabolic process CCL2 1726.65786727582 2140.44712489151 1312.86860966013 0.613361850611784 -0.705189657080538 8.85367388734041e-07 0.000708049934540451 129.955 127.428 81.9904 77.74 GeneID:6347,Genbank:NM_002982.3,HGNC:HGNC:10618,MIM:158105 C-C motif chemokine ligand 2 hsa04060,hsa04062,hsa04621,hsa04657,hsa04668,hsa04933,hsa05142,hsa05144,hsa05163,hsa05164,hsa05168,hsa05323,hsa05418 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Chagas disease (American trypanosomiasis)|Malaria|Human cytomegalovirus infection|Influenza A|Herpes simplex infection|Rheumatoid arthritis|Fluid shear stress and atherosclerosis CCL25 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0425581 0.0396861 GeneID:6370,Genbank:XM_011528177.2,HGNC:HGNC:10624,MIM:602565 C-C motif chemokine ligand 25 hsa04060,hsa04062,hsa04672 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|Intestinal immune network for IgA production CCL26 69.5025843542222 77.4684821279855 61.536686580459 0.7943448082382 -0.332162708233545 0.347192994674366 1 3.07697 4.46398 2.58474 3.33421 GeneID:10344,Genbank:NM_006072.4,HGNC:HGNC:10625,MIM:604697 C-C motif chemokine ligand 26 hsa04060,hsa04062 Cytokine-cytokine receptor interaction|Chemokine signaling pathway CCL27 2.24247141269929 2.54640955915669 1.93853326624189 0.76128101988585 -0.393498985236256 0.964560642378451 1 0 0.240628 0 0 GeneID:10850,Genbank:NM_006664.3,HGNC:HGNC:10626,MIM:604833 C-C motif chemokine ligand 27 hsa04060,hsa04062 Cytokine-cytokine receptor interaction|Chemokine signaling pathway CCL3 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0 GeneID:6348,Genbank:NM_002983.2,HGNC:HGNC:10627,MIM:182283 C-C motif chemokine ligand 3 hsa04060,hsa04062,hsa04620,hsa05132,hsa05142,hsa05163,hsa05323 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|Toll-like receptor signaling pathway|Salmonella infection|Chagas disease (American trypanosomiasis)|Human cytomegalovirus infection|Rheumatoid arthritis CCL5 3.64551691845906 1.47021420587209 5.82081963104604 3.95916432299286 1.98519594689495 0.565831454799604 1 0 0.0581068 0.181739 0 GeneID:6352,Genbank:NM_002985.2,HGNC:HGNC:10632,MIM:187011 C-C motif chemokine ligand 5 hsa04060,hsa04062,hsa04620,hsa04621,hsa04623,hsa04668,hsa05020,hsa05120,hsa05142,hsa05163,hsa05164,hsa05168,hsa05323 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|TNF signaling pathway|Prion diseases|Epithelial cell signaling in Helicobacter pylori infection|Chagas disease (American trypanosomiasis)|Human cytomegalovirus infection|Influenza A|Herpes simplex infection|Rheumatoid arthritis CCL7 1.4593380350783 0.980142803914724 1.93853326624189 1.97780696700452 0.983901626635446 0.869495943289778 1 0 0.125659 0.125047 0.116655 GeneID:6354,Genbank:NM_006273.3,HGNC:HGNC:10634,MIM:158106 C-C motif chemokine ligand 7 hsa04060,hsa04062,hsa04657 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|IL-17 signaling pathway CCM2 1816.27890787368 1674.69837494268 1957.85944080467 1.1690818299574 0.225375914935423 0.11820212313599 1 12.6833 14.4115 16.4688 16.206 GeneID:83605,Genbank:NM_031443.3,HGNC:HGNC:21708,MIM:607929 CCM2 scaffold protein GO:0001570,GO:0001701,GO:0001885,GO:0005737,GO:0005739,GO:0007229,GO:0035264,GO:0043234,GO:0045216,GO:0048839,GO:0048845,GO:0051403,GO:0060039,GO:0060837,GO:0061154 vasculogenesis|in utero embryonic development|endothelial cell development|cytoplasm|mitochondrion|integrin-mediated signaling pathway|multicellular organism growth|protein complex|cell-cell junction organization|inner ear development|venous blood vessel morphogenesis|stress-activated MAPK cascade|pericardium development|blood vessel endothelial cell differentiation|endothelial tube morphogenesis CCM2L 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:140706,Genbank:XM_011528566.2,HGNC:HGNC:16153 CCM2 like scaffold protein GO:0003209,GO:0003222,GO:0032091,GO:0034111,GO:0042060,GO:0055017,GO:0090271 cardiac atrium morphogenesis|ventricular trabecula myocardium morphogenesis|negative regulation of protein binding|negative regulation of homotypic cell-cell adhesion|wound healing|cardiac muscle tissue growth|positive regulation of fibroblast growth factor production CCNA1 233.94481884527 216.357551633202 251.532086057339 1.1625759496658 0.217324968803057 0.311580828967713 1 2.69271 2.31575 3.2356 2.72256 GeneID:8900,Genbank:XM_011535294.2,HGNC:HGNC:1577,MIM:604036 cyclin A1 hsa04110,hsa04152,hsa04218,hsa04914,hsa05161,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05221 Cell cycle|AMPK signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Hepatitis B|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Acute myeloid leukemia CCNA2 2230.6571956208 2267.26670579143 2194.04768545017 0.96770603998452 -0.0473592282383582 0.751008367146495 1 33.9395 32.401 35.4171 29.339 GeneID:890,Genbank:NM_001237.4,HGNC:HGNC:1578,MIM:123835 cyclin A2 hsa04110,hsa04152,hsa04218,hsa04914,hsa05161,hsa05165,hsa05169,hsa05203 Cell cycle|AMPK signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Hepatitis B|Human papillomavirus infection|Epstein-Barr virus infection|Viral carcinogenesis CCNB1 8582.95649196136 9077.98147130119 8087.93151262153 0.890939416233712 -0.166600762882973 0.202614452332789 1 164.377 168.107 142.368 155.242 GeneID:891,Genbank:NM_031966.3,HGNC:HGNC:1579,MIM:123836 cyclin B1 hsa04068,hsa04110,hsa04114,hsa04115,hsa04218,hsa04914,hsa05170 FoxO signaling pathway|Cell cycle|Oocyte meiosis|p53 signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Human immunodeficiency virus 1 infection CCNB1IP1 729.887919434389 704.738880968899 755.03695789988 1.07137122456168 0.0994584530465591 0.548577830338351 1 15.9318 17.5712 18.0054 18.1377 GeneID:57820,Genbank:NM_182849.2,HGNC:HGNC:19437,MIM:608249 cyclin B1 interacting protein 1 GO:0000795,GO:0001825,GO:0007131,GO:0007286,GO:0016567,GO:0046872,GO:0051026,GO:0061630 synaptonemal complex|blastocyst formation|reciprocal meiotic recombination|spermatid development|protein ubiquitination|metal ion binding|chiasma assembly|ubiquitin protein ligase activity CCNB2 3293.93346278587 3288.97185461884 3298.89507095289 1.0030171180456 0.00434622799272511 0.977448612159482 1 74.6628 78.198 80.0953 74.4592 GeneID:9133,Genbank:NM_004701.3,HGNC:HGNC:1580,MIM:602755 cyclin B2 hsa04068,hsa04110,hsa04114,hsa04115,hsa04218,hsa04914,hsa05166,hsa05170 FoxO signaling pathway|Cell cycle|Oocyte meiosis|p53 signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection CCNB3 11.241240912754 8.90752912949446 13.5749526960136 1.52398633769992 0.607849969352935 0.5408962215526 1 0.0687126 0.0236296 0.107801 0.044699 GeneID:85417,Genbank:XM_017029915.1,HGNC:HGNC:18709,MIM:300456 cyclin B3 GO:0000079,GO:0010389,GO:0016607,GO:0019901,GO:0051301,GO:0051321 regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of G2/M transition of mitotic cell cycle|nuclear speck|protein kinase binding|cell division|meiotic cell cycle hsa04068,hsa04110,hsa04218,hsa04914,hsa05170 FoxO signaling pathway|Cell cycle|Cellular senescence|Progesterone-mediated oocyte maturation|Human immunodeficiency virus 1 infection CCNC 1393.31526056183 1574.0788330614 1212.55168806225 0.770324625802871 -0.376461548637832 0.0105736220223851 0.413204483866249 20.979 19.7081 16.8272 15.529 GeneID:892,Genbank:NM_001013399.1,HGNC:HGNC:1581,MIM:123838 cyclin C GO:0000307,GO:0004674,GO:0005634,GO:0005654,GO:0006367,GO:0016538,GO:0016592,GO:0045737,GO:0045944,GO:1901409 cyclin-dependent protein kinase holoenzyme complex|protein serine/threonine kinase activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|cyclin-dependent protein serine/threonine kinase regulator activity|mediator complex|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of phosphorylation of RNA polymerase II C-terminal domain CCND1 13507.2363756757 15548.386148453 11466.0866028984 0.737445448898839 -0.439391762154553 0.000671181885801113 0.0757017541055678 165.968 172.596 138.705 114.422 GeneID:595,Genbank:NM_053056.2,HGNC:HGNC:1582,MIM:168461 cyclin D1 hsa01522,hsa04068,hsa04110,hsa04115,hsa04151,hsa04152,hsa04218,hsa04310,hsa04340,hsa04371,hsa04390,hsa04510,hsa04530,hsa04630,hsa04917,hsa04919,hsa04921,hsa04933,hsa04934,hsa05161,hsa05162,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05416 Endocrine resistance|FoxO signaling pathway|Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Cellular senescence|Wnt signaling pathway|Hedgehog signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Focal adhesion|Tight junction|Jak-STAT signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Hepatitis B|Measles|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Viral myocarditis CCND3 4685.54905876986 4302.03024000126 5069.06787753846 1.17829666337654 0.236702816671638 0.0796243503952138 0.946740836643754 68.2683 70.6444 82.9589 84.6003 GeneID:896,Genbank:NM_001136126.2,HGNC:HGNC:1585,MIM:123834 cyclin D3 hsa04110,hsa04115,hsa04151,hsa04218,hsa04310,hsa04390,hsa04510,hsa04630,hsa05162,hsa05165,hsa05166,hsa05169,hsa05200,hsa05203 Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Wnt signaling pathway|Hippo signaling pathway|Focal adhesion|Jak-STAT signaling pathway|Measles|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis CCNDBP1 1148.2278032456 1208.97498295575 1087.48062353546 0.899506308126191 -0.152794695933716 0.299708124708987 1 11.2433 12.6286 10.5874 10.8011 GeneID:23582,Genbank:XM_006720448.2,HGNC:HGNC:1587,MIM:607089 cyclin D1 binding protein 1 GO:0005634,GO:0005654,GO:0005737,GO:0007049,GO:0051726 nucleus|nucleoplasm|cytoplasm|cell cycle|regulation of cell cycle CCNE1 433.97232687953 474.947487729 392.997166030059 0.827453931610855 -0.273249102588867 0.128074603576951 1 9.92275 10.1594 7.4065 8.9195 GeneID:898,Genbank:NM_001238.3,HGNC:HGNC:1589,MIM:123837 cyclin E1 hsa04110,hsa04114,hsa04115,hsa04151,hsa04218,hsa04934,hsa05161,hsa05162,hsa05165,hsa05169,hsa05200,hsa05203,hsa05206,hsa05215,hsa05222,hsa05226 Cell cycle|Oocyte meiosis|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Cushing syndrome|Hepatitis B|Measles|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Prostate cancer|Small cell lung cancer|Gastric cancer CCNE2 210.521379954091 224.755392050524 196.287367857658 0.873337747614679 -0.19538839684502 0.472457557749861 1 2.23431 1.69612 2.08371 1.5433 GeneID:9134,Genbank:NM_057749.2,HGNC:HGNC:1590,MIM:603775 cyclin E2 hsa04110,hsa04114,hsa04115,hsa04151,hsa04218,hsa04934,hsa05161,hsa05162,hsa05165,hsa05169,hsa05200,hsa05203,hsa05206,hsa05215,hsa05222,hsa05226 Cell cycle|Oocyte meiosis|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Cushing syndrome|Hepatitis B|Measles|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Prostate cancer|Small cell lung cancer|Gastric cancer CCNF 1365.61012914275 1313.69434149376 1417.52591679175 1.07903784923054 0.109745470886636 0.461380270817573 1 11.8923 11.9465 13.2224 13.0348 GeneID:899,Genbank:NM_001323538.1,HGNC:HGNC:1591,MIM:600227 cyclin F GO:0000209,GO:0000320,GO:0001890,GO:0004842,GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0010826,GO:0016567,GO:0019005,GO:0030054,GO:0031146,GO:0043687,GO:0051301 protein polyubiquitination|re-entry into mitotic cell cycle|placenta development|ubiquitin-protein transferase activity|nucleus|centrosome|centriole|cytosol|negative regulation of centrosome duplication|protein ubiquitination|SCF ubiquitin ligase complex|cell junction|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|cell division CCNG1 1029.99719486795 1139.62395825038 920.370431485512 0.80760888258134 -0.308271316479521 0.0460356654442563 0.79332376136203 19.5691 17.7791 16.4622 13.4808 GeneID:900,Genbank:NM_004060.3,HGNC:HGNC:1592,MIM:601578 cyclin G1 hsa04115,hsa05206 p53 signaling pathway|MicroRNAs in cancer CCNG2 292.950698620274 284.95672225127 300.944674989278 1.05610659966783 0.0787554625849292 0.697267132039932 1 2.29625 2.25404 2.33691 2.37687 GeneID:901,Genbank:NM_004354.2,HGNC:HGNC:1593,MIM:603203 cyclin G2 hsa04068,hsa04115 FoxO signaling pathway|p53 signaling pathway CCNH 1120.19343534173 1169.29678270571 1071.09008797774 0.916012174000232 -0.126561322708099 0.418523880016931 1 8.2259 7.70965 8.43495 6.70724 GeneID:902,Genbank:XM_011543706.3,HGNC:HGNC:1594,MIM:601953 cyclin H GO:0000307,GO:0005634,GO:0005675,GO:0006366,GO:0006468,GO:0007049,GO:0016538,GO:0045737,GO:0045944,GO:0070985,GO:1901409 cyclin-dependent protein kinase holoenzyme complex|nucleus|holo TFIIH complex|transcription from RNA polymerase II promoter|protein phosphorylation|cell cycle|cyclin-dependent protein serine/threonine kinase regulator activity|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription from RNA polymerase II promoter|TFIIK complex|positive regulation of phosphorylation of RNA polymerase II C-terminal domain hsa03022,hsa03420,hsa04110 Basal transcription factors|Nucleotide excision repair|Cell cycle CCNI 4542.6818830753 4459.01845741015 4626.34530874045 1.0375254897302 0.0531467807541312 0.686528050613675 1 76.3125 75.2976 82.2467 77.704 GeneID:10983,Genbank:NM_001348134.1,HGNC:HGNC:1595 cyclin I CCNI2 2.79870915526048 2.69048838321152 2.90692992730943 1.08044693500574 0.111628217515297 1 1 0 0 0.0443567 0.0206879 GeneID:645121,Genbank:NM_001287253.1,HGNC:HGNC:33869 cyclin I family member 2 CCNJ 279.395555661193 326.169729289519 232.621382032866 0.713191204283656 -0.487639184429502 0.0180017610165872 0.547089571995561 3.14927 2.8057 2.15435 2.12591 GeneID:54619,Genbank:XM_011539885.2,HGNC:HGNC:23434 cyclin J GO:0005634 nucleus CCNJL 651.720623171271 587.153204466165 716.288041876377 1.21993380335482 0.286802865687539 0.0877746457567992 0.970228836454666 3.55649 4.14525 4.99486 4.58858 GeneID:79616,Genbank:XM_011534646.3,HGNC:HGNC:25876 cyclin J like GO:0005634 nucleus CCNK 1160.6152960803 1240.98249456129 1080.24809759932 0.870478110959336 -0.200120074561195 0.176976785363891 1 10.9902 11.1634 10.2482 9.55215 GeneID:8812,Genbank:NM_001099402.1,HGNC:HGNC:1596,MIM:603544 cyclin K CCNL1 441.867244060343 477.098861434714 406.635626685971 0.852308943817537 -0.230551623446558 0.216563897544476 1 3.33941 2.81452 2.99203 2.36415 GeneID:57018,Genbank:NM_001308185.1,HGNC:HGNC:20569,MIM:613384 cyclin L1 GO:0000307,GO:0005634,GO:0006351,GO:0006396,GO:0016538,GO:0016607,GO:0045737,GO:0045944,GO:1901409 cyclin-dependent protein kinase holoenzyme complex|nucleus|transcription, DNA-templated|RNA processing|cyclin-dependent protein serine/threonine kinase regulator activity|nuclear speck|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of phosphorylation of RNA polymerase II C-terminal domain CCNL2 1905.82688305502 1969.13792461881 1842.51584149123 0.935696691661609 -0.0958871423751928 0.495953195814466 1 15.5457 15.5536 14.7688 14.7559 GeneID:81669,Genbank:NM_030937.5,HGNC:HGNC:20570,MIM:613482 cyclin L2 GO:0000307,GO:0005634,GO:0005654,GO:0006351,GO:0016538,GO:0016607,GO:0043231,GO:0045737,GO:0045944,GO:1901409 cyclin-dependent protein kinase holoenzyme complex|nucleus|nucleoplasm|transcription, DNA-templated|cyclin-dependent protein serine/threonine kinase regulator activity|nuclear speck|intracellular membrane-bounded organelle|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of phosphorylation of RNA polymerase II C-terminal domain CCNO 149.279903926036 157.059928997216 141.499878854857 0.900929217008398 -0.150514332114257 0.576546469752565 1 7.14481 4.78278 5.02618 6.19939 GeneID:10309,Genbank:NM_021147.4,HGNC:HGNC:18576,MIM:607752 cyclin O GO:0004844,GO:0005654,GO:0005737,GO:0006284,GO:0007049,GO:0042493,GO:0051301,GO:0060271,GO:1903251 uracil DNA N-glycosylase activity|nucleoplasm|cytoplasm|base-excision repair|cell cycle|response to drug|cell division|cilium assembly|multi-ciliated epithelial cell differentiation CCNQ 621.101678272821 635.485942814603 606.71741373104 0.954729873400276 -0.0668354930813839 0.691032688661758 1 9.5045 9.4704 8.83631 9.96643 GeneID:92002,Genbank:NM_001130997.2,HGNC:HGNC:28434,MIM:300708 cyclin Q GO:0000307,GO:0005634,GO:0016538,GO:0045737,GO:0045944,GO:1901409 cyclin-dependent protein kinase holoenzyme complex|nucleus|cyclin-dependent protein serine/threonine kinase regulator activity|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of phosphorylation of RNA polymerase II C-terminal domain CCNT1 428.598341701356 459.773874577683 397.422808825028 0.864387540919053 -0.210249817210808 0.259142547108602 1 2.95379 2.62721 2.68509 2.1409 GeneID:904,Genbank:NM_001277842.1,HGNC:HGNC:1599,MIM:143055 cyclin T1 GO:0000307,GO:0003682,GO:0005634,GO:0006351,GO:0006468,GO:0007049,GO:0008024,GO:0008134,GO:0016032,GO:0016538,GO:0019901,GO:0044212,GO:0045737,GO:0045944,GO:0051301,GO:0070063,GO:0097322,GO:1900364,GO:1901409 cyclin-dependent protein kinase holoenzyme complex|chromatin binding|nucleus|transcription, DNA-templated|protein phosphorylation|cell cycle|cyclin/CDK positive transcription elongation factor complex|transcription factor binding|viral process|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|transcription regulatory region DNA binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription from RNA polymerase II promoter|cell division|RNA polymerase binding|7SK snRNA binding|negative regulation of mRNA polyadenylation|positive regulation of phosphorylation of RNA polymerase II C-terminal domain hsa05202 Transcriptional misregulation in cancer CCNT2 248.847089358105 268.909844501371 228.784334214839 0.850784524601784 -0.233134303341614 0.349082790852047 1 1.05979 1.14335 1.11303 0.718797 GeneID:905,Genbank:XM_017005227.1,HGNC:HGNC:1600,MIM:603862 cyclin T2 hsa05202 Transcriptional misregulation in cancer CCNY 1535.10269263921 1527.59274446292 1542.6126408155 1.00983239571347 0.0141158653155675 0.941150036497387 1 12.0424 13.1227 13.7664 11.9113 GeneID:219771,Genbank:NM_181698.3,HGNC:HGNC:23354,MIM:612786 cyclin Y GO:0000086,GO:0000308,GO:0005634,GO:0005886,GO:0016055,GO:0016538,GO:0019901,GO:0045737,GO:0051301,GO:0060828,GO:0070062 G2/M transition of mitotic cell cycle|cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane|Wnt signaling pathway|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|cell division|regulation of canonical Wnt signaling pathway|extracellular exosome CCNYL1 390.06532180832 394.326854780315 385.803788836325 0.978385783669899 -0.0315246537959215 0.885683554868262 1 4.45915 4.23731 4.94496 3.71409 GeneID:151195,Genbank:NM_001330218.1,HGNC:HGNC:26868 cyclin Y like 1 GO:0000079,GO:0019901 regulation of cyclin-dependent protein serine/threonine kinase activity|protein kinase binding CCP110 150.021618644742 150.737027046456 149.306210243028 0.990507861064644 -0.013759669925075 1 1 0.93625 0.743523 1.05776 0.558462 GeneID:9738,Genbank:NM_001323570.1,HGNC:HGNC:24342,MIM:609544 centriolar coiled-coil protein 110 GO:0000086,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0007099,GO:0010389,GO:0016579,GO:0032053,GO:0032465,GO:0043234,GO:0045724,GO:0051298,GO:0097711,GO:1902018 G2/M transition of mitotic cell cycle|centrosome|centriole|cytosol|cilium|centriole replication|regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|ciliary basal body organization|regulation of cytokinesis|protein complex|positive regulation of cilium assembly|centrosome duplication|ciliary basal body-plasma membrane docking|negative regulation of cilium assembly CCPG1 440.38027585082 427.111578435063 453.648973266577 1.06213223001059 0.0869633854502117 0.76331446494559 1 2.46743 1.79748 2.57074 1.96251 GeneID:9236,Genbank:NM_001204451.1,HGNC:HGNC:24227,MIM:611326 cell cycle progression 1 GO:0007049,GO:0016021,GO:2001106 cell cycle|integral component of membrane|regulation of Rho guanyl-nucleotide exchange factor activity CCR1 1.26820168020816 1.56626675524197 0.97013660517434 0.619394239153384 -0.691070129994731 0.974558099637673 1 0.0321355 0.0149251 0.0304784 0 GeneID:1230,Genbank:NM_001295.2,HGNC:HGNC:1602,MIM:601159 C-C motif chemokine receptor 1 hsa04060,hsa04062,hsa05163,hsa05167 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection CCR10 18.1331684522194 15.9126075809524 20.3537293234864 1.27909453054383 0.355122889479271 0.620425757439891 1 0.928624 1.20608 1.25286 1.39895 GeneID:2826,Genbank:NM_016602.2,HGNC:HGNC:4474,MIM:600240 C-C motif chemokine receptor 10 hsa04060,hsa04062,hsa04672 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|Intestinal immune network for IgA production CCR2 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.0212874 0.0100533 0 0 GeneID:729230,Genbank:NM_001123396.2,HGNC:HGNC:1603,MIM:601267 C-C motif chemokine receptor 2 GO:0001974,GO:0005886,GO:0006935,GO:0006954,GO:0006955,GO:0016021,GO:0016493,GO:0090026 blood vessel remodeling|plasma membrane|chemotaxis|inflammatory response|immune response|integral component of membrane|C-C chemokine receptor activity|positive regulation of monocyte chemotaxis hsa04060,hsa04062 Cytokine-cytokine receptor interaction|Chemokine signaling pathway CCR5 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0111385 0.0105607 0 0 GeneID:1234,Genbank:NM_000579.3,HGNC:HGNC:1606,MIM:601373 C-C motif chemokine receptor 5 (gene/pseudogene) hsa04060,hsa04062,hsa04144,hsa05145,hsa05163,hsa05167,hsa05170,hsa05203 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|Endocytosis|Toxoplasmosis|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis CCR6 5.69337208807462 4.60274771635603 6.7839964597932 1.47390143406862 0.559640048628998 0.710715919214347 1 0.0666598 0.0628616 0.0638966 0.0947993 GeneID:1235,Genbank:NM_004367.5,HGNC:HGNC:1607,MIM:601835 C-C motif chemokine receptor 6 hsa04060,hsa04062 Cytokine-cytokine receptor interaction|Chemokine signaling pathway CCR7 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0152348 0 0.0149756 GeneID:1236,Genbank:NM_001301714.1,HGNC:HGNC:1608,MIM:600242 C-C motif chemokine receptor 7 hsa04060,hsa04062 Cytokine-cytokine receptor interaction|Chemokine signaling pathway CCRL2 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0 0 0.047125 0 GeneID:9034,Genbank:XM_011534209.1,HGNC:HGNC:1612,MIM:608379 C-C motif chemokine receptor like 2 GO:0004950,GO:0005886,GO:0005887,GO:0006935,GO:0006954,GO:0007186,GO:0042379,GO:0048020 chemokine receptor activity|plasma membrane|integral component of plasma membrane|chemotaxis|inflammatory response|G-protein coupled receptor signaling pathway|chemokine receptor binding|CCR chemokine receptor binding CCS 171.993807469827 156.44539608142 187.542218858235 1.1987710955753 0.261556203534605 0.288788016933424 1 5.55329 6.09316 6.40581 7.08671 GeneID:9973,Genbank:NM_005125.1,HGNC:HGNC:1613,MIM:603864 copper chaperone for superoxide dismutase GO:0005507,GO:0005634,GO:0005737,GO:0005829,GO:0006801,GO:0008270,GO:0015035,GO:0015680,GO:0016532,GO:0034599,GO:0045296,GO:0051353 copper ion binding|nucleus|cytoplasm|cytosol|superoxide metabolic process|zinc ion binding|protein disulfide oxidoreductase activity|intracellular copper ion transport|superoxide dismutase copper chaperone activity|cellular response to oxidative stress|cadherin binding|positive regulation of oxidoreductase activity hsa05014 Amyotrophic lateral sclerosis (ALS) CCSAP 446.43035752103 480.414708389685 412.446006652376 0.858520772677559 -0.220075052941446 0.222004668227225 1 3.25802 3.2679 3.1423 2.60153 GeneID:126731,Genbank:NM_145257.4,HGNC:HGNC:29578,MIM:616762 centriole, cilia and spindle associated protein GO:0005813,GO:0005814,GO:0005819,GO:0005929,GO:0005930,GO:0007049,GO:0008017,GO:0030424,GO:0035869,GO:0036064,GO:0045995,GO:0048666,GO:0051301,GO:0060296,GO:0061673,GO:0072686,GO:1901673,GO:1990755 centrosome|centriole|spindle|cilium|axoneme|cell cycle|microtubule binding|axon|ciliary transition zone|ciliary basal body|regulation of embryonic development|neuron development|cell division|regulation of cilium beat frequency involved in ciliary motility|mitotic spindle astral microtubule|mitotic spindle|regulation of mitotic spindle assembly|mitotic spindle microtubule depolymerization CCSER2 498.203624329633 467.586608044531 528.820640614734 1.13095762692239 0.17754487753807 0.527004531999099 1 1.64127 1.69459 2.27308 1.51729 GeneID:54462,Genbank:XM_005269905.4,HGNC:HGNC:29197 coiled-coil serine rich protein 2 GO:0001578,GO:0008017,GO:0015630 microtubule bundle formation|microtubule binding|microtubule cytoskeleton CCT2 5647.54322231265 6119.38705783478 5175.69938679051 0.845787223111498 -0.241633328435178 0.069079308825325 0.918407228165493 113.486 111.562 95.2095 96.5923 GeneID:10576,Genbank:NM_006431.2,HGNC:HGNC:1615,MIM:605139 chaperonin containing TCP1 subunit 2 GO:0002199,GO:0005524,GO:0005576,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0007339,GO:0031012,GO:0031625,GO:0032212,GO:0035578,GO:0043209,GO:0043312,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0051086,GO:0051131,GO:0051973,GO:0070062,GO:0090666,GO:1901998,GO:1904851,GO:1904871,GO:1904874 zona pellucida receptor complex|ATP binding|extracellular region|cytosol|chaperonin-containing T-complex|microtubule|protein folding|binding of sperm to zona pellucida|extracellular matrix|ubiquitin protein ligase binding|positive regulation of telomere maintenance via telomerase|azurophil granule lumen|myelin sheath|neutrophil degranulation|protein binding involved in protein folding|cell body|protein stabilization|unfolded protein binding|chaperone mediated protein folding independent of cofactor|chaperone-mediated protein complex assembly|positive regulation of telomerase activity|extracellular exosome|scaRNA localization to Cajal body|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT3 12308.0401890105 13359.8815832035 11256.1987948176 0.842537317768543 -0.247187507148008 0.0555052302455034 0.855410907895938 185.767 193.864 153.945 168.608 GeneID:7203,Genbank:NM_001008800.2,HGNC:HGNC:1616,MIM:600114 chaperonin containing TCP1 subunit 3 GO:0002199,GO:0003723,GO:0005524,GO:0005829,GO:0005832,GO:0005856,GO:0005874,GO:0005886,GO:0006457,GO:0006458,GO:0007339,GO:0032212,GO:0043209,GO:0044183,GO:0044297,GO:0046931,GO:0050821,GO:0051082,GO:0061077,GO:0070062,GO:1901998,GO:1904871,GO:1904874 zona pellucida receptor complex|RNA binding|ATP binding|cytosol|chaperonin-containing T-complex|cytoskeleton|microtubule|plasma membrane|protein folding|'de novo' protein folding|binding of sperm to zona pellucida|positive regulation of telomere maintenance via telomerase|myelin sheath|protein binding involved in protein folding|cell body|pore complex assembly|protein stabilization|unfolded protein binding|chaperone-mediated protein folding|extracellular exosome|toxin transport|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT4 5257.82343919214 5681.17632494322 4834.47055344106 0.850962947975282 -0.232831778412133 0.0798960654402797 0.9478632474752 95.7418 98.6457 82.7936 85.2261 GeneID:10575,Genbank:NM_001256721.1,HGNC:HGNC:1617,MIM:605142 chaperonin containing TCP1 subunit 4 GO:0002199,GO:0003723,GO:0005524,GO:0005654,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0006458,GO:0007339,GO:0032212,GO:0042470,GO:0042995,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0051973,GO:0061077,GO:0070062,GO:0090666,GO:1901998,GO:1904851,GO:1904871,GO:1904874 zona pellucida receptor complex|RNA binding|ATP binding|nucleoplasm|centrosome|cytosol|chaperonin-containing T-complex|microtubule|protein folding|'de novo' protein folding|binding of sperm to zona pellucida|positive regulation of telomere maintenance via telomerase|melanosome|cell projection|protein binding involved in protein folding|cell body|protein stabilization|unfolded protein binding|positive regulation of telomerase activity|chaperone-mediated protein folding|extracellular exosome|scaRNA localization to Cajal body|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT5 11489.1133435507 12360.8803639978 10617.3463231036 0.858947422064499 -0.219358271146845 0.0911618722142824 0.981875282706084 108.706 109.349 95.0025 97.217 GeneID:22948,Genbank:NM_012073.4,HGNC:HGNC:1618,MIM:610150 chaperonin containing TCP1 subunit 5 GO:0002199,GO:0003730,GO:0005524,GO:0005730,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0006458,GO:0007339,GO:0009615,GO:0031681,GO:0032212,GO:0043209,GO:0044183,GO:0044297,GO:0048027,GO:0048487,GO:0050821,GO:0051082,GO:0061077,GO:0070062,GO:1901998,GO:1904851,GO:1904871,GO:1904874 zona pellucida receptor complex|mRNA 3'-UTR binding|ATP binding|nucleolus|centrosome|cytosol|chaperonin-containing T-complex|microtubule|protein folding|'de novo' protein folding|binding of sperm to zona pellucida|response to virus|G-protein beta-subunit binding|positive regulation of telomere maintenance via telomerase|myelin sheath|protein binding involved in protein folding|cell body|mRNA 5'-UTR binding|beta-tubulin binding|protein stabilization|unfolded protein binding|chaperone-mediated protein folding|extracellular exosome|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT6A 9056.90118028677 9690.71611386677 8423.08624670677 0.869191311326713 -0.20225434186899 0.125899603800709 1 145.06 139.783 132.52 118.638 GeneID:908,Genbank:NM_001762.3,HGNC:HGNC:1620,MIM:104613 chaperonin containing TCP1 subunit 6A GO:0003723,GO:0005524,GO:0005737,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0006458,GO:0031012,GO:0032212,GO:0044183,GO:0050821,GO:0051082,GO:0061077,GO:0070062,GO:0071987,GO:1904851,GO:1904871,GO:1904874 RNA binding|ATP binding|cytoplasm|cytosol|chaperonin-containing T-complex|microtubule|protein folding|'de novo' protein folding|extracellular matrix|positive regulation of telomere maintenance via telomerase|protein binding involved in protein folding|protein stabilization|unfolded protein binding|chaperone-mediated protein folding|extracellular exosome|WD40-repeat domain binding|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT6B 22.6172413055646 21.0054266992657 24.2290559118634 1.15346649505151 0.205976098407489 0.763299454239698 1 0.343784 0.347881 0.330796 0.306861 GeneID:10693,Genbank:NM_001193530.1,HGNC:HGNC:1621,MIM:610730 chaperonin containing TCP1 subunit 6B GO:0005524,GO:0005829,GO:0005832,GO:0006457,GO:0006458,GO:0007283,GO:0008565,GO:0044183,GO:0051082,GO:0051131,GO:0061077,GO:1901998 ATP binding|cytosol|chaperonin-containing T-complex|protein folding|'de novo' protein folding|spermatogenesis|protein transporter activity|protein binding involved in protein folding|unfolded protein binding|chaperone-mediated protein complex assembly|chaperone-mediated protein folding|toxin transport CCT7 8099.40430650635 8504.78872481498 7694.01988819771 0.904669138428844 -0.144537838187495 0.259379006887257 1 126.624 136.534 117.219 125.205 GeneID:10574,Genbank:XM_011532478.3,HGNC:HGNC:1622,MIM:605140 chaperonin containing TCP1 subunit 7 GO:0002199,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0006458,GO:0007339,GO:0032212,GO:0042802,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0061077,GO:0070062,GO:1901998,GO:1904851,GO:1904871,GO:1904874 zona pellucida receptor complex|ATP binding|cytoplasm|mitochondrion|cytosol|chaperonin-containing T-complex|microtubule|protein folding|'de novo' protein folding|binding of sperm to zona pellucida|positive regulation of telomere maintenance via telomerase|identical protein binding|protein binding involved in protein folding|cell body|protein stabilization|unfolded protein binding|chaperone-mediated protein folding|extracellular exosome|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCT8 3059.36090380878 3390.72913343318 2727.99267418439 0.804544558657283 -0.313755769931556 0.0223961626545222 0.610028811351747 50.765 47.1206 42.0185 39.4462 GeneID:10694,Genbank:NM_001282909.1,HGNC:HGNC:1623,MIM:617786 chaperonin containing TCP1 subunit 8 GO:0002199,GO:0005524,GO:0005576,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0005929,GO:0006457,GO:0006458,GO:0007339,GO:0032212,GO:0034774,GO:0035578,GO:0042623,GO:0043312,GO:0044183,GO:0044297,GO:0045111,GO:0045296,GO:0046931,GO:0050821,GO:0051082,GO:0061077,GO:0070062,GO:1901998,GO:1904813,GO:1904851,GO:1904871,GO:1904874 zona pellucida receptor complex|ATP binding|extracellular region|nucleoplasm|cytoplasm|centrosome|cytosol|chaperonin-containing T-complex|microtubule|cilium|protein folding|'de novo' protein folding|binding of sperm to zona pellucida|positive regulation of telomere maintenance via telomerase|secretory granule lumen|azurophil granule lumen|ATPase activity, coupled|neutrophil degranulation|protein binding involved in protein folding|cell body|intermediate filament cytoskeleton|cadherin binding|pore complex assembly|protein stabilization|unfolded protein binding|chaperone-mediated protein folding|extracellular exosome|toxin transport|ficolin-1-rich granule lumen|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body CCZ1 511.068950776793 540.414124836584 481.723776717002 0.89139745720501 -0.165859249354065 0.334587246117186 1 9.73455 10.6313 9.23101 8.83799 GeneID:51622,Genbank:NM_015622.5,HGNC:HGNC:21691 CCZ1 homolog, vacuolar protein trafficking and biogenesis associated GO:0005765,GO:0005829,GO:0016192,GO:0016235,GO:0031982,GO:0043231 lysosomal membrane|cytosol|vesicle-mediated transport|aggresome|vesicle|intracellular membrane-bounded organelle CCZ1B 786.206436748357 805.700347424659 766.712526072054 0.951610022910843 -0.071557627740101 0.666599690386196 1 14.0542 13.5459 14.2012 12.6322 GeneID:221960,Genbank:NM_198097.3,HGNC:HGNC:21717 CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated GO:0005765,GO:0005829,GO:0016192,GO:0016235,GO:0031982,GO:0043231 lysosomal membrane|cytosol|vesicle-mediated transport|aggresome|vesicle|intracellular membrane-bounded organelle CD101 27.4205642020493 26.7323960435913 28.1087323605073 1.05148570725466 0.0724292397863226 0.924781042509079 1 0.203306 0.192873 0.158298 0.167142 GeneID:9398,Genbank:XM_017002846.2,HGNC:HGNC:5949,MIM:604516 CD101 molecule GO:0002763,GO:0005886,GO:0007166,GO:0016021,GO:0016812,GO:0070062 positive regulation of myeloid leukocyte differentiation|plasma membrane|cell surface receptor signaling pathway|integral component of membrane|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides|extracellular exosome CD109 3610.80980761467 3502.02504060045 3719.59457462888 1.06212677850845 0.0869559806515773 0.746153278702022 1 17.0406 13.9817 19.966 13.6157 GeneID:135228,Genbank:NM_133493.4,HGNC:HGNC:21685,MIM:608859 CD109 molecule CD14 12.0962065641111 10.1376119619418 14.0548011662804 1.38640157258379 0.471345196048648 0.613853127263019 1 0.179946 0.316405 0.416933 0.311704 GeneID:929,Genbank:NM_001174105.1,HGNC:HGNC:1628,MIM:158120 CD14 molecule hsa04010,hsa04064,hsa04145,hsa04620,hsa04640,hsa05130,hsa05132,hsa05133,hsa05134,hsa05146,hsa05152,hsa05202,hsa05221 MAPK signaling pathway|NF-kappa B signaling pathway|Phagosome|Toll-like receptor signaling pathway|Hematopoietic cell lineage|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Legionellosis|Amoebiasis|Tuberculosis|Transcriptional misregulation in cancer|Acute myeloid leukemia CD151 7170.13995508748 6863.89648495311 7476.38342522185 1.08923312605477 0.123312763796427 0.39415378792374 1 172.189 182.549 187.952 205.189 GeneID:977,Genbank:NM_004357.4,HGNC:HGNC:1630,MIM:602243 CD151 molecule (Raph blood group) CD160 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0 0 GeneID:11126,Genbank:XM_011509104.2,HGNC:HGNC:17013,MIM:604463 CD160 molecule GO:0004872,GO:0005102,GO:0005886,GO:0006968,GO:0007166,GO:0008283,GO:0032393,GO:0046658,GO:0050776,GO:0050829 receptor activity|receptor binding|plasma membrane|cellular defense response|cell surface receptor signaling pathway|cell proliferation|MHC class I receptor activity|anchored component of plasma membrane|regulation of immune response|defense response to Gram-negative bacterium CD163L1 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0112788 GeneID:283316,Genbank:XM_011520616.1,HGNC:HGNC:30375,MIM:606079 CD163 molecule like 1 GO:0005044,GO:0005576,GO:0005886,GO:0016021 scavenger receptor activity|extracellular region|plasma membrane|integral component of membrane CD164 3383.21073788632 3040.53406279093 3725.88741298171 1.22540558205807 0.293259328313923 0.266478359052552 1 40.9257 36.3302 56.5868 38.7738 GeneID:8763,Genbank:NM_001142401.2,HGNC:HGNC:1632,MIM:603356 CD164 molecule GO:0005576,GO:0005764,GO:0005765,GO:0005768,GO:0005886,GO:0005887,GO:0006955,GO:0007155,GO:0007157,GO:0007162,GO:0007165,GO:0007275,GO:0007517,GO:0008285,GO:0010008,GO:0030097 extracellular region|lysosome|lysosomal membrane|endosome|plasma membrane|integral component of plasma membrane|immune response|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|negative regulation of cell adhesion|signal transduction|multicellular organism development|muscle organ development|negative regulation of cell proliferation|endosome membrane|hemopoiesis hsa04142 Lysosome CD164L2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:388611,Genbank:XM_011541441.1,HGNC:HGNC:32043 CD164 molecule like 2 GO:0016021,GO:0031410 integral component of membrane|cytoplasmic vesicle CD177 26.0596814942098 25.464095591567 26.6552673968526 1.04677848467079 0.0659561768641311 0.958650737611597 1 0.19933 0.320814 0.211286 0.278745 GeneID:57126,Genbank:NM_020406.3,HGNC:HGNC:30072,MIM:162860 CD177 molecule GO:0002020,GO:0005178,GO:0005886,GO:0007155,GO:0007159,GO:0007596,GO:0030027,GO:0030100,GO:0030667,GO:0031225,GO:0032930,GO:0034394,GO:0035579,GO:0043312,GO:0043315,GO:0044853,GO:0045087,GO:0045217,GO:0048306,GO:0050900,GO:0070062,GO:0070821,GO:0072672,GO:0098742,GO:1990266,GO:2001044 protease binding|integrin binding|plasma membrane|cell adhesion|leukocyte cell-cell adhesion|blood coagulation|lamellipodium|regulation of endocytosis|secretory granule membrane|anchored component of membrane|positive regulation of superoxide anion generation|protein localization to cell surface|specific granule membrane|neutrophil degranulation|positive regulation of neutrophil degranulation|plasma membrane raft|innate immune response|cell-cell junction maintenance|calcium-dependent protein binding|leukocyte migration|extracellular exosome|tertiary granule membrane|neutrophil extravasation|cell-cell adhesion via plasma-membrane adhesion molecules|neutrophil migration|regulation of integrin-mediated signaling pathway CD180 54.770973334905 33.929579593789 75.6123670760209 2.22850881093328 1.15607866499572 0.00317421327635221 0.211825832641904 0.402378 0.401905 1.07137 0.760757 GeneID:4064,Genbank:NM_005582.2,HGNC:HGNC:6726,MIM:602226 CD180 molecule GO:0002224,GO:0002322,GO:0004872,GO:0005887,GO:0006954,GO:0031666,GO:0045087,GO:0071222 toll-like receptor signaling pathway|B cell proliferation involved in immune response|receptor activity|integral component of plasma membrane|inflammatory response|positive regulation of lipopolysaccharide-mediated signaling pathway|innate immune response|cellular response to lipopolysaccharide CD200R1 1.02523254288787 1.56626675524197 0.484198330533773 0.309141676482158 -1.69365993276169 0.789571303159055 1 0.0338774 0.0163692 0 0.0151871 GeneID:131450,Genbank:NM_170780.2,HGNC:HGNC:24235,MIM:607546 CD200 receptor 1 GO:0004872,GO:0005576,GO:0005886,GO:0009897,GO:0016021,GO:0016032,GO:0043235,GO:0050776 receptor activity|extracellular region|plasma membrane|external side of plasma membrane|integral component of membrane|viral process|receptor complex|regulation of immune response hsa05167 Kaposi sarcoma-associated herpesvirus infection CD200R1L 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0152666 0 0 0 GeneID:344807,Genbank:XM_011512763.3,HGNC:HGNC:24665 CD200 receptor 1 like GO:0004872,GO:0009897,GO:0016021 receptor activity|external side of plasma membrane|integral component of membrane hsa05167 Kaposi sarcoma-associated herpesvirus infection CD22 2.4655605399939 3.47852608838648 1.45259499160132 0.417589218735774 -1.25984362981198 0.589440956012381 1 0.0108177 0.0386596 0 0.018875 GeneID:933,Genbank:NM_001278417.1,HGNC:HGNC:1643,MIM:107266 CD22 molecule hsa04514,hsa04640,hsa04662 Cell adhesion molecules (CAMs)|Hematopoietic cell lineage|B cell receptor signaling pathway CD226 0.996651292201907 0.538097676642304 1.45520490776151 2.70435084730694 1.43528233092293 0.835161298535314 1 0.00572524 0 0.0110874 0 GeneID:10666,Genbank:XM_006722374.3,HGNC:HGNC:16961,MIM:605397 CD226 molecule GO:0001816,GO:0002729,GO:0002860,GO:0002891,GO:0004872,GO:0005178,GO:0005886,GO:0005887,GO:0005913,GO:0007155,GO:0007156,GO:0007157,GO:0007165,GO:0008037,GO:0009897,GO:0009986,GO:0019901,GO:0032729,GO:0033005,GO:0042803,GO:0045121,GO:0045954,GO:0050776,GO:0050839,GO:0050862,GO:0060369 cytokine production|positive regulation of natural killer cell cytokine production|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of immunoglobulin mediated immune response|receptor activity|integrin binding|plasma membrane|integral component of plasma membrane|cell-cell adherens junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|cell recognition|external side of plasma membrane|cell surface|protein kinase binding|positive regulation of interferon-gamma production|positive regulation of mast cell activation|protein homodimerization activity|membrane raft|positive regulation of natural killer cell mediated cytotoxicity|regulation of immune response|cell adhesion molecule binding|positive regulation of T cell receptor signaling pathway|positive regulation of Fc receptor mediated stimulatory signaling pathway hsa04514 Cell adhesion molecules (CAMs) CD24 1881.42390331889 1816.06315941959 1946.78464721819 1.07198069468045 0.100278924508779 0.460235568119767 1 24.1533 21.6655 25.9912 24.1716 GeneID:100133941,Genbank:NM_001291738.1,HGNC:HGNC:1645,MIM:600074 CD24 molecule GO:0016021 integral component of membrane hsa04640 Hematopoietic cell lineage CD247 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0 0 GeneID:919,Genbank:NM_000734.3,HGNC:HGNC:1677,MIM:186780 CD247 molecule GO:0002250,GO:0004888,GO:0007166,GO:0016021 adaptive immune response|transmembrane signaling receptor activity|cell surface receptor signaling pathway|integral component of membrane hsa04650,hsa04658,hsa04659,hsa04660,hsa05142,hsa05169,hsa05170 Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Chagas disease (American trypanosomiasis)|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection CD27 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0.0195856 0 0 0 GeneID:939,Genbank:XM_017020232.1,HGNC:HGNC:11922,MIM:186711 CD27 molecule hsa04060 Cytokine-cytokine receptor interaction CD274 440.439455637455 423.345911699422 457.532999575488 1.08075450106233 0.112038844697186 0.534622476849159 1 4.61238 4.07527 5.23028 4.0279 GeneID:29126,Genbank:NM_014143.3,HGNC:HGNC:17635,MIM:605402 CD274 molecule GO:0005886,GO:0006955,GO:0007165,GO:0007166,GO:0009897,GO:0012505,GO:0016021,GO:0030335,GO:0031295,GO:0032689,GO:0032693,GO:0034097,GO:0042102,GO:0046007,GO:0070062,GO:1901998,GO:1903556,GO:1905404,GO:2001181 plasma membrane|immune response|signal transduction|cell surface receptor signaling pathway|external side of plasma membrane|endomembrane system|integral component of membrane|positive regulation of cell migration|T cell costimulation|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|response to cytokine|positive regulation of T cell proliferation|negative regulation of activated T cell proliferation|extracellular exosome|toxin transport|negative regulation of tumor necrosis factor superfamily cytokine production|positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process|positive regulation of interleukin-10 secretion hsa04514 Cell adhesion molecules (CAMs) CD276 3108.58235756107 2886.24817642206 3330.91653870007 1.1540644931058 0.206723849012907 0.133820569647583 1 33.7049 34.4309 41.5647 37.7947 GeneID:80381,Genbank:XM_017022638.1,HGNC:HGNC:19137,MIM:605715 CD276 molecule GO:0005102,GO:0006955,GO:0008283,GO:0009897,GO:0016021,GO:0042102,GO:0042110,GO:0045078,GO:0050776,GO:0070062 receptor binding|immune response|cell proliferation|external side of plasma membrane|integral component of membrane|positive regulation of T cell proliferation|T cell activation|positive regulation of interferon-gamma biosynthetic process|regulation of immune response|extracellular exosome hsa04514 Cell adhesion molecules (CAMs) CD28 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00720543 0 0.00692958 0 GeneID:940,Genbank:NM_006139.3,HGNC:HGNC:1653,MIM:186760 CD28 molecule hsa04514,hsa04660,hsa04672,hsa04940,hsa05162,hsa05320,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416 Cell adhesion molecules (CAMs)|T cell receptor signaling pathway|Intestinal immune network for IgA production|Type I diabetes mellitus|Measles|Autoimmune thyroid disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis CD2AP 325.773897907544 365.556720888885 285.991074926202 0.782343911584469 -0.354125151718258 0.348295187331235 1 2.38947 1.90634 2.1433 1.33491 GeneID:23607,Genbank:XM_005248976.1,HGNC:HGNC:14258,MIM:604241 CD2 associated protein GO:0001726,GO:0005172,GO:0005200,GO:0005737,GO:0005886,GO:0005911,GO:0006461,GO:0006930,GO:0007015,GO:0007049,GO:0007165,GO:0008013,GO:0008022,GO:0015629,GO:0016050,GO:0017124,GO:0030139,GO:0031941,GO:0032403,GO:0032911,GO:0043161,GO:0045296,GO:0048259,GO:0048471,GO:0051058,GO:0051301,GO:0070062,GO:0098609,GO:1900182,GO:2000249 ruffle|vascular endothelial growth factor receptor binding|structural constituent of cytoskeleton|cytoplasm|plasma membrane|cell-cell junction|protein complex assembly|substrate-dependent cell migration, cell extension|actin filament organization|cell cycle|signal transduction|beta-catenin binding|protein C-terminus binding|actin cytoskeleton|vesicle organization|SH3 domain binding|endocytic vesicle|filamentous actin|protein complex binding|negative regulation of transforming growth factor beta1 production|proteasome-mediated ubiquitin-dependent protein catabolic process|cadherin binding|regulation of receptor-mediated endocytosis|perinuclear region of cytoplasm|negative regulation of small GTPase mediated signal transduction|cell division|extracellular exosome|cell-cell adhesion|positive regulation of protein localization to nucleus|regulation of actin cytoskeleton reorganization hsa05100 Bacterial invasion of epithelial cells CD2BP2 2198.16036846892 2067.35310176328 2328.96763517457 1.12654564582517 0.171905770449913 0.223318590153451 1 18.377 19.778 21.2173 23.1963 GeneID:10421,Genbank:NM_006110.2,HGNC:HGNC:1656,MIM:604470 CD2 cytoplasmic tail binding protein 2 GO:0000244,GO:0000398,GO:0001650,GO:0005634,GO:0005654,GO:0005682,GO:0005737,GO:0005829,GO:0010923,GO:0016607,GO:0043021 spliceosomal tri-snRNP complex assembly|mRNA splicing, via spliceosome|fibrillar center|nucleus|nucleoplasm|U5 snRNP|cytoplasm|cytosol|negative regulation of phosphatase activity|nuclear speck|ribonucleoprotein complex binding CD302 3.16371177113529 2.45035700978681 3.87706653248377 1.58224557360362 0.661973531748084 0.815733297504404 1 1.69807 1.53773 1.90516 1.4404 GeneID:9936,Genbank:NM_001198764.1,HGNC:HGNC:30843,MIM:612246 CD302 molecule GO:0004888,GO:0005887,GO:0005902,GO:0005938,GO:0006909,GO:0016020,GO:0030175,GO:0030246 transmembrane signaling receptor activity|integral component of plasma membrane|microvillus|cell cortex|phagocytosis|membrane|filopodium|carbohydrate binding CD320 2686.91743354583 2713.88138110544 2659.95348598623 0.980128868013663 -0.0289566466580455 0.819756434509328 1 100.633 102.246 95.6563 106.079 GeneID:51293,Genbank:NM_001165895.1,HGNC:HGNC:16692,MIM:606475 CD320 molecule GO:0005509,GO:0005783,GO:0005886,GO:0005887,GO:0008083,GO:0009235,GO:0010008,GO:0015889,GO:0016020,GO:0030656,GO:0030890,GO:0031296,GO:0031419,GO:0070062 calcium ion binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|growth factor activity|cobalamin metabolic process|endosome membrane|cobalamin transport|membrane|regulation of vitamin metabolic process|positive regulation of B cell proliferation|B cell costimulation|cobalamin binding|extracellular exosome CD33 3.19566454355975 3.96859749034384 2.42273159677566 0.610475515007634 -0.711994662222513 0.731963663033557 1 0.0117947 0.0739448 0.0221203 0.0310705 GeneID:945,Genbank:XM_017027508.1,HGNC:HGNC:1659,MIM:159590 CD33 molecule hsa04640 Hematopoietic cell lineage CD34 86.6112707543469 91.8050142985879 81.4175272101058 0.886852726206243 -0.17323354933822 0.594847355063573 1 1.07601 0.967728 0.877824 0.906461 GeneID:947,Genbank:NM_001025109.1,HGNC:HGNC:1662,MIM:142230 CD34 molecule hsa04514,hsa04640 Cell adhesion molecules (CAMs)|Hematopoietic cell lineage CD36 5.99731023453202 7.14915727551272 4.84546319355132 0.677767043977055 -0.561138606555845 0.688992769845043 1 0.0234726 0.0459101 0.0304067 0.0423394 GeneID:948,Genbank:NM_001001547.2,HGNC:HGNC:1663,MIM:173510 CD36 molecule hsa03320,hsa04145,hsa04152,hsa04512,hsa04640,hsa04920,hsa04931,hsa04975,hsa04979,hsa05144 PPAR signaling pathway|Phagosome|AMPK signaling pathway|ECM-receptor interaction|Hematopoietic cell lineage|Adipocytokine signaling pathway|Insulin resistance|Fat digestion and absorption|Cholesterol metabolism|Malaria CD37 3.24369081824469 4.06465003971372 2.42273159677566 0.596049247316331 -0.746496559629732 0.730868430300716 1 0.0225355 0.0194658 0.0207903 0.0194233 GeneID:951,Genbank:XM_011527543.3,HGNC:HGNC:1666,MIM:151523 CD37 molecule GO:0001772,GO:0005887,GO:0007166,GO:0016020,GO:0070062 immunological synapse|integral component of plasma membrane|cell surface receptor signaling pathway|membrane|extracellular exosome hsa04640 Hematopoietic cell lineage CD38 6.83606999617352 4.94874029425856 8.72339969808849 1.76275156492031 0.817829161377823 0.531010797876076 1 0.00823307 0.0700171 0.0708847 0.058717 GeneID:952,Genbank:NM_001775.3,HGNC:HGNC:1667,MIM:107270 CD38 molecule hsa00760,hsa04020,hsa04640,hsa04921,hsa04970,hsa04972 Nicotinate and nicotinamide metabolism|Calcium signaling pathway|Hematopoietic cell lineage|Oxytocin signaling pathway|Salivary secretion|Pancreatic secretion CD3EAP 1184.63820515588 1364.69896791605 1004.57744239572 0.73611651068349 -0.441993964362961 0.00297816787514 0.204505366014363 12.547 13.1074 8.95424 9.86399 GeneID:10849,Genbank:NM_001297590.1,HGNC:HGNC:24219,MIM:107325 CD3e molecule associated protein GO:0000120,GO:0001650,GO:0003723,GO:0003899,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005739,GO:0005829,GO:0006361,GO:0006362,GO:0006363,GO:0007169,GO:0009303,GO:0045815 RNA polymerase I transcription factor complex|fibrillar center|RNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|chromosome|nucleolus|mitochondrion|cytosol|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transmembrane receptor protein tyrosine kinase signaling pathway|rRNA transcription|positive regulation of gene expression, epigenetic CD4 1.27070322989325 2.05633815719933 0.48506830258717 0.235889365223771 -2.08381771694066 0.63179572723844 1 0 0.0198092 0 0 GeneID:920,Genbank:NM_000616.4,HGNC:HGNC:1678,MIM:186940 CD4 molecule hsa04060,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04660,hsa05170,hsa05340 Cytokine-cytokine receptor interaction|Cell adhesion molecules (CAMs)|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Human immunodeficiency virus 1 infection|Primary immunodeficiency CD40 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0155947 GeneID:958,Genbank:XM_017028135.1,HGNC:HGNC:11919,MIM:109535 CD40 molecule hsa04060,hsa04064,hsa04514,hsa04620,hsa04672,hsa05144,hsa05145,hsa05166,hsa05169,hsa05202,hsa05310,hsa05320,hsa05322,hsa05330,hsa05340,hsa05416 Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Cell adhesion molecules (CAMs)|Toll-like receptor signaling pathway|Intestinal immune network for IgA production|Malaria|Toxoplasmosis|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Transcriptional misregulation in cancer|Asthma|Autoimmune thyroid disease|Systemic lupus erythematosus|Allograft rejection|Primary immunodeficiency|Viral myocarditis CD44 34109.4861211513 30326.8799330861 37892.0923092164 1.24945567736683 0.32129972481219 0.0122292621999898 0.452341485900777 116.008 119.065 161.461 133.562 GeneID:960,Genbank:NM_000610.3,HGNC:HGNC:1681,MIM:107269 CD44 molecule (Indian blood group) GO:0005540,GO:0005886,GO:0007155,GO:0016021,GO:0016324,GO:0031258,GO:0042995,GO:0044319,GO:2000392 hyaluronic acid binding|plasma membrane|cell adhesion|integral component of membrane|apical plasma membrane|lamellipodium membrane|cell projection|wound healing, spreading of cells|regulation of lamellipodium morphogenesis hsa04512,hsa04640,hsa05131,hsa05169,hsa05205,hsa05206 ECM-receptor interaction|Hematopoietic cell lineage|Shigellosis|Epstein-Barr virus infection|Proteoglycans in cancer|MicroRNAs in cancer CD46 2151.26759434971 2225.22540942672 2077.3097792727 0.933527799238943 -0.0992351102216286 0.605096898739389 1 26.4802 24.0059 26.6348 20.3692 GeneID:4179,Genbank:NM_002389.4,HGNC:HGNC:6953,MIM:120920 CD46 molecule GO:0002079,GO:0006958,GO:0007338,GO:0009986,GO:0016021,GO:0045087 inner acrosomal membrane|complement activation, classical pathway|single fertilization|cell surface|integral component of membrane|innate immune response hsa04610,hsa05162 Complement and coagulation cascades|Measles CD47 1070.97177508693 1055.80416520716 1086.13938496669 1.02873186217595 0.0408669943606399 0.774179383072254 1 3.97231 3.42324 4.29471 3.34951 GeneID:961,Genbank:NM_198793.2,HGNC:HGNC:1682,MIM:601028 CD47 molecule GO:0005886,GO:0005887,GO:0007155,GO:0007229,GO:0008228,GO:0008284,GO:0009617,GO:0022409,GO:0030198,GO:0035579,GO:0043312,GO:0050729,GO:0050766,GO:0050870,GO:0050900,GO:0070053,GO:0070062,GO:0070821 plasma membrane|integral component of plasma membrane|cell adhesion|integrin-mediated signaling pathway|opsonization|positive regulation of cell proliferation|response to bacterium|positive regulation of cell-cell adhesion|extracellular matrix organization|specific granule membrane|neutrophil degranulation|positive regulation of inflammatory response|positive regulation of phagocytosis|positive regulation of T cell activation|leukocyte migration|thrombospondin receptor activity|extracellular exosome|tertiary granule membrane hsa04512 ECM-receptor interaction CD55 498.386676094156 530.035364500363 466.73798768795 0.880578955571993 -0.18347572830357 0.306797272503184 1 5.46709 5.16977 5.07132 4.18465 GeneID:1604,Genbank:NM_001114752.2,HGNC:HGNC:2665,MIM:125240 CD55 molecule (Cromer blood group) hsa04610,hsa04640,hsa05416 Complement and coagulation cascades|Hematopoietic cell lineage|Viral myocarditis CD58 849.55390968085 907.1813112477 791.926508114 0.87295284668598 -0.196024367366619 0.2202650034617 1 4.13697 3.90296 3.76733 3.18627 GeneID:965,Genbank:XM_017002869.2,HGNC:HGNC:1688,MIM:153420 CD58 molecule GO:0005102,GO:0005886,GO:0005887,GO:0007155,GO:0009986,GO:0016020,GO:0030667,GO:0031225,GO:0034113,GO:0043312,GO:0050900,GO:0070062,GO:0071346,GO:0071356,GO:0098609,GO:0101003,GO:2000484 receptor binding|plasma membrane|integral component of plasma membrane|cell adhesion|cell surface|membrane|secretory granule membrane|anchored component of membrane|heterotypic cell-cell adhesion|neutrophil degranulation|leukocyte migration|extracellular exosome|cellular response to interferon-gamma|cellular response to tumor necrosis factor|cell-cell adhesion|ficolin-1-rich granule membrane|positive regulation of interleukin-8 secretion hsa04514,hsa05169 Cell adhesion molecules (CAMs)|Epstein-Barr virus infection CD59 8899.09063165928 8704.14054585286 9094.04071746571 1.04479479272639 0.0632196116002227 0.626665773302339 1 40.5481 40.7116 41.1524 44.3181 GeneID:966,Genbank:NM_000611.5,HGNC:HGNC:1689,MIM:107271 CD59 molecule (CD59 blood group) hsa04610,hsa04640 Complement and coagulation cascades|Hematopoietic cell lineage CD63 17964.0410274802 17171.279360964 18756.8026939964 1.09233577182588 0.127416392785559 0.574638392062147 1 287.943 289.355 289.952 353.136 GeneID:967,Genbank:NM_001257389.1,HGNC:HGNC:1692,MIM:155740 CD63 molecule GO:0002092,GO:0002576,GO:0005615,GO:0005765,GO:0005886,GO:0005887,GO:0007160,GO:0009986,GO:0010008,GO:0015031,GO:0016477,GO:0031088,GO:0031226,GO:0031902,GO:0031904,GO:0032585,GO:0034613,GO:0035577,GO:0035646,GO:0042470,GO:0043312,GO:0048757,GO:0070062,GO:0097487,GO:1900746,GO:2000680,GO:2001046 positive regulation of receptor internalization|platelet degranulation|extracellular space|lysosomal membrane|plasma membrane|integral component of plasma membrane|cell-matrix adhesion|cell surface|endosome membrane|protein transport|cell migration|platelet dense granule membrane|intrinsic component of plasma membrane|late endosome membrane|endosome lumen|multivesicular body membrane|cellular protein localization|azurophil granule membrane|endosome to melanosome transport|melanosome|neutrophil degranulation|pigment granule maturation|extracellular exosome|multivesicular body, internal vesicle|regulation of vascular endothelial growth factor signaling pathway|regulation of rubidium ion transport|positive regulation of integrin-mediated signaling pathway hsa04142,hsa05205 Lysosome|Proteoglycans in cancer CD68 621.56645381049 583.587417482662 659.545490138319 1.13015714592221 0.176523390233309 0.290297923937454 1 9.74072 9.5193 10.7087 11.3741 GeneID:968,Genbank:NM_001251.2,HGNC:HGNC:1693,MIM:153634 CD68 molecule GO:0005886,GO:0010008,GO:0016020,GO:0016021,GO:0035577,GO:0043312,GO:0071310 plasma membrane|endosome membrane|membrane|integral component of membrane|azurophil granule membrane|neutrophil degranulation|cellular response to organic substance hsa04142 Lysosome CD69 0.97720626820293 1.47021420587209 0.484198330533773 0.329338628752101 -1.60235635659317 0.793508671995383 1 0 0.0517928 0 0.0237424 GeneID:969,Genbank:NM_001781.2,HGNC:HGNC:1694,MIM:107273 CD69 molecule CD70 12005.7325902309 12162.7539021415 11848.7112783203 0.974179973849022 -0.0377397687872842 0.749197846259666 1 138.963 157.305 143.745 149.048 GeneID:970,Genbank:NM_001330332.1,HGNC:HGNC:11937,MIM:602840 CD70 molecule GO:0002020,GO:0005102,GO:0005125,GO:0005164,GO:0005886,GO:0005887,GO:0006955,GO:0007165,GO:0007267,GO:0008283,GO:0033209,GO:0070062,GO:0097191 protease binding|receptor binding|cytokine activity|tumor necrosis factor receptor binding|plasma membrane|integral component of plasma membrane|immune response|signal transduction|cell-cell signaling|cell proliferation|tumor necrosis factor-mediated signaling pathway|extracellular exosome|extrinsic apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction CD72 2.21302018995993 1.51824048055703 2.90779989936283 1.91524329419539 0.937527669974993 0.766544435698746 1 0 0 0 0.0251989 GeneID:971,Genbank:NM_001782.2,HGNC:HGNC:1696,MIM:107272 CD72 molecule hsa04662 B cell receptor signaling pathway CD79A 3.28921554324454 3.67063118712625 2.90779989936283 0.792179805359132 -0.336100171074252 0.957039415790012 1 0.189276 0.0664832 0.105692 0.0329492 GeneID:973,Genbank:NM_001783.3,HGNC:HGNC:1698,MIM:112205 CD79a molecule hsa04662,hsa05340 B cell receptor signaling pathway|Primary immunodeficiency CD80 7.90803676186105 11.4539386886512 4.36213483507094 0.380841468916981 -1.39273751607462 0.202978555025625 1 0.00720668 0.00691167 0 0.00646157 GeneID:941,Genbank:XM_011513327.2,HGNC:HGNC:1700,MIM:112203 CD80 molecule GO:0001618,GO:0005622,GO:0005886,GO:0009967,GO:0009986,GO:0015026,GO:0016021,GO:0019221,GO:0031295,GO:0035556,GO:0045086,GO:0045425,GO:0045627,GO:0045893,GO:0046934,GO:0050731,GO:0051897,GO:0098636 virus receptor activity|intracellular|plasma membrane|positive regulation of signal transduction|cell surface|coreceptor activity|integral component of membrane|cytokine-mediated signaling pathway|T cell costimulation|intracellular signal transduction|positive regulation of interleukin-2 biosynthetic process|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-templated|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling|protein complex involved in cell adhesion hsa04514,hsa04620,hsa04672,hsa04940,hsa05320,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416 Cell adhesion molecules (CAMs)|Toll-like receptor signaling pathway|Intestinal immune network for IgA production|Type I diabetes mellitus|Autoimmune thyroid disease|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis CD81 2985.38549363999 2949.22623890028 3021.5447483797 1.0245211806831 0.0349498105576574 0.815439286028861 1 70.8124 73.1821 73.8636 76.6204 GeneID:975,Genbank:NM_001297649.1,HGNC:HGNC:1701,MIM:186845 CD81 molecule GO:0000187,GO:0001618,GO:0001772,GO:0005886,GO:0005887,GO:0005925,GO:0007166,GO:0008104,GO:0008283,GO:0008284,GO:0016020,GO:0016323,GO:0023026,GO:0030449,GO:0030890,GO:0031623,GO:0031647,GO:0031982,GO:0043128,GO:0045944,GO:0046718,GO:0046813,GO:0050731,GO:0050776,GO:0061462,GO:0070062,GO:0071404,GO:1904352,GO:1990459,GO:2000145 activation of MAPK activity|virus receptor activity|immunological synapse|plasma membrane|integral component of plasma membrane|focal adhesion|cell surface receptor signaling pathway|protein localization|cell proliferation|positive regulation of cell proliferation|membrane|basolateral plasma membrane|MHC class II protein complex binding|regulation of complement activation|positive regulation of B cell proliferation|receptor internalization|regulation of protein stability|vesicle|positive regulation of 1-phosphatidylinositol 4-kinase activity|positive regulation of transcription from RNA polymerase II promoter|viral entry into host cell|receptor-mediated virion attachment to host cell|positive regulation of peptidyl-tyrosine phosphorylation|regulation of immune response|protein localization to lysosome|extracellular exosome|cellular response to low-density lipoprotein particle stimulus|positive regulation of protein catabolic process in the vacuole|transferrin receptor binding|regulation of cell motility hsa04662,hsa05144,hsa05160 B cell receptor signaling pathway|Malaria|Hepatitis C CD82 1172.03750284861 1490.16502147053 853.909984226696 0.573030484492274 -0.803316204324081 7.92983489556555e-08 7.05579087152099e-05 24.2527 24.8133 14.6548 14.1581 GeneID:3732,Genbank:NM_002231.3,HGNC:HGNC:6210,MIM:600623 CD82 molecule hsa04115 p53 signaling pathway CD83 410.300777096616 381.566398020062 439.035156173171 1.15061273333111 0.202402341102216 0.270919688222432 1 6.47617 6.70325 7.13486 8.23298 GeneID:9308,Genbank:NM_001251901.1,HGNC:HGNC:1703,MIM:604534 CD83 molecule CD8A 2.47793590096429 1.07619535328461 3.87967644864396 3.60499275229444 1.84999635898361 0.460064433529833 1 0.0132522 0 0.086508 0.0115644 GeneID:925,Genbank:NM_001145873.1,HGNC:HGNC:1706,MIM:186910 CD8a molecule hsa04514,hsa04612,hsa04640,hsa04660,hsa05340 Cell adhesion molecules (CAMs)|Antigen processing and presentation|Hematopoietic cell lineage|T cell receptor signaling pathway|Primary immunodeficiency CD9 3453.83354960983 3403.1486826198 3504.51841659986 1.02978704236396 0.0423460221747297 0.813486650102518 1 75.5003 79.292 74.4924 85.0308 GeneID:928,Genbank:NM_001330312.1,HGNC:HGNC:1709,MIM:143030 CD9 molecule hsa04640 Hematopoietic cell lineage CD96 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00414661 GeneID:10225,Genbank:NM_198196.2,HGNC:HGNC:16892,MIM:606037 CD96 molecule GO:0002534,GO:0002728,GO:0005737,GO:0005886,GO:0005887,GO:0005912,GO:0006955,GO:0007155,GO:0007160,GO:0032496,GO:0032689,GO:0050776 cytokine production involved in inflammatory response|negative regulation of natural killer cell cytokine production|cytoplasm|plasma membrane|integral component of plasma membrane|adherens junction|immune response|cell adhesion|cell-matrix adhesion|response to lipopolysaccharide|negative regulation of interferon-gamma production|regulation of immune response CD99 1996.68120930837 1823.48289103471 2169.87952758204 1.18996429209752 0.250918282451911 0.0833062658061228 0.963076417285947 12.7095 11.2407 18.0705 11.5091 GeneID:4267,Genbank:NM_002414.4,HGNC:HGNC:7082,MIM:450000 CD99 molecule (Xg blood group) GO:0005737,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0050776 cytoplasm|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|regulation of immune response hsa04514,hsa04670 Cell adhesion molecules (CAMs)|Leukocyte transendothelial migration CD99L2 3299.58036071279 2889.27484872807 3709.8858726975 1.28401971668797 0.36066735584773 0.00827889373163438 0.356525902221039 18.837 19.4845 26.1075 24.1687 GeneID:83692,Genbank:NM_134445.3,HGNC:HGNC:18237,MIM:300846 CD99 molecule like 2 GO:0005886,GO:0005925,GO:0007155,GO:0016021 plasma membrane|focal adhesion|cell adhesion|integral component of membrane CDA 2.50814872928195 2.59443583384164 2.42186162472226 0.933482953454339 -0.0993044175793639 1 1 0.11341 0.100022 0 0.196433 GeneID:978,Genbank:NM_001785.2,HGNC:HGNC:1712,MIM:123920 cytidine deaminase hsa00240,hsa00983 Pyrimidine metabolism|Drug metabolism - other enzymes CDADC1 136.532167155446 145.115918906608 127.948415404285 0.881697999560121 -0.181643508430865 0.507299022571733 1 0.943452 0.806201 0.842135 0.717314 GeneID:81602,Genbank:XM_011535253.1,HGNC:HGNC:20299 cytidine and dCMP deaminase domain containing 1 GO:0004126,GO:0005634,GO:0005737,GO:0008270,GO:0009972,GO:0042803,GO:0061676,GO:0070383 cytidine deaminase activity|nucleus|cytoplasm|zinc ion binding|cytidine deamination|protein homodimerization activity|importin-alpha family protein binding|DNA cytosine deamination CDAN1 972.592617999602 934.23230790558 1010.95292809362 1.08212156605892 0.113862581326172 0.468118799807191 1 7.53338 7.71211 8.86849 8.09892 GeneID:146059,Genbank:NM_138477.3,HGNC:HGNC:1713,MIM:607465 codanin 1 GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006325,GO:0008104,GO:0008156,GO:0012505,GO:0016021,GO:0031497 nucleus|cytoplasm|cytosol|plasma membrane|chromatin organization|protein localization|negative regulation of DNA replication|endomembrane system|integral component of membrane|chromatin assembly CDC123 1728.6466466504 1811.98971772562 1645.30357557517 0.90800933332024 -0.139220968003748 0.33870410144145 1 45.6487 42.3558 41.101 39.943 GeneID:8872,Genbank:NM_006023.2,HGNC:HGNC:16827,MIM:617708 cell division cycle 123 GO:0005737,GO:0006417,GO:0007050,GO:0008284,GO:0045948,GO:0051301,GO:1905143 cytoplasm|regulation of translation|cell cycle arrest|positive regulation of cell proliferation|positive regulation of translational initiation|cell division|eukaryotic translation initiation factor 2 complex assembly CDC14A 55.9686356881853 60.0758516860531 51.8614196903175 0.863265658909625 -0.212123496302335 0.597645623717919 1 0.260656 0.249993 0.228189 0.202265 GeneID:8556,Genbank:XM_024450503.1,HGNC:HGNC:1718,MIM:603504 cell division cycle 14A hsa04110 Cell cycle CDC14B 422.876118484739 433.791298619689 411.960938349789 0.94967543069821 -0.07449356515995 0.698370060097595 1 2.28928 2.21441 2.46111 1.95514 GeneID:8555,Genbank:XM_011519158.1,HGNC:HGNC:1719,MIM:603505 cell division cycle 14B GO:0004725,GO:0005730,GO:0008138,GO:0016021 protein tyrosine phosphatase activity|nucleolus|protein tyrosine/serine/threonine phosphatase activity|integral component of membrane hsa04110 Cell cycle CDC14C 9.35813020377727 10.9638672866938 7.75239312086075 0.707085640325962 -0.500043133896442 0.656110568015273 1 0.188027 0.0961379 0.0832341 0.128864 GeneID:168448,Genbank:NM_152627.2,HGNC:HGNC:22427 cell division cycle 14C GO:0000922,GO:0004722,GO:0004725,GO:0005634,GO:0005730,GO:0005737,GO:0005813,GO:0007096,GO:0008138,GO:0016021,GO:0051256,GO:0060271,GO:0071850,GO:0072686 spindle pole|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|nucleus|nucleolus|cytoplasm|centrosome|regulation of exit from mitosis|protein tyrosine/serine/threonine phosphatase activity|integral component of membrane|mitotic spindle midzone assembly|cilium assembly|mitotic cell cycle arrest|mitotic spindle CDC16 1027.75502973325 1059.13962947235 996.37042999414 0.940735670980907 -0.0881386851487888 0.569736227180071 1 12.7588 13.5952 11.9883 12.6739 GeneID:8881,Genbank:NM_001078645.2,HGNC:HGNC:1720,MIM:603461 cell division cycle 16 hsa04110,hsa04114,hsa04120,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC20 5672.00919001121 5716.75470853653 5627.26367148588 0.984345832274906 -0.0227628252043797 0.845852012609906 1 123.058 128.892 123.639 129.983 GeneID:991,Genbank:NM_001255.2,HGNC:HGNC:1723,MIM:603618 cell division cycle 20 hsa04110,hsa04114,hsa04120,hsa05166,hsa05203 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Human T-cell leukemia virus 1 infection|Viral carcinogenesis CDC20B 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:166979,Genbank:NM_001145734.2,HGNC:HGNC:24222 cell division cycle 20B GO:0010997,GO:0097027,GO:1904668 anaphase-promoting complex binding|ubiquitin-protein transferase activator activity|positive regulation of ubiquitin protein ligase activity CDC23 1558.75134974745 1498.31190485846 1619.19079463643 1.08067671983784 0.111935011102285 0.43026102635809 1 17.7815 17.3615 20.4504 18.0472 GeneID:8697,Genbank:NM_004661.3,HGNC:HGNC:1724,MIM:603462 cell division cycle 23 hsa04110,hsa04114,hsa04120,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC25A 1176.85734724244 1202.21984453283 1151.49484995205 0.957807222355004 -0.0621927806159509 0.66529397371973 1 10.5156 11.0976 10.89 10.2578 GeneID:993,Genbank:XM_006713435.3,HGNC:HGNC:1725,MIM:116947 cell division cycle 25A hsa04110,hsa04218,hsa04914,hsa05206 Cell cycle|Cellular senescence|Progesterone-mediated oocyte maturation|MicroRNAs in cancer CDC25B 3718.10120747663 3665.84046937403 3770.36194557923 1.0285122817205 0.0405590215453614 0.771678472227604 1 37.0774 36.953 38.6223 38.5675 GeneID:994,Genbank:NM_001287516.1,HGNC:HGNC:1726,MIM:116949 cell division cycle 25B hsa04010,hsa04110,hsa04914,hsa05206 MAPK signaling pathway|Cell cycle|Progesterone-mediated oocyte maturation|MicroRNAs in cancer CDC25C 813.887994892815 817.001415635002 810.774574150627 0.992378420201959 -0.0110377314890593 0.942573776165061 1 9.40581 9.89586 9.95575 9.23847 GeneID:995,Genbank:NM_001287583.1,HGNC:HGNC:1727,MIM:157680 cell division cycle 25C hsa04110,hsa04114,hsa04914,hsa05170,hsa05206 Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human immunodeficiency virus 1 infection|MicroRNAs in cancer CDC26 233.784697163007 235.440910344216 232.128483981798 0.98593096519388 -0.0204414621373343 0.959329435219139 1 3.82332 3.55434 4.31317 4.28712 GeneID:246184,Genbank:NM_139286.3,HGNC:HGNC:17839,MIM:614533 cell division cycle 26 GO:0005654,GO:0005680,GO:0005829,GO:0030071,GO:0031145,GO:0042787,GO:0043161,GO:0051301,GO:0051436,GO:0051437,GO:0051439,GO:0070979 nucleoplasm|anaphase-promoting complex|cytosol|regulation of mitotic metaphase/anaphase transition|anaphase-promoting complex-dependent catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination hsa04110,hsa04114,hsa04120,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC27 1334.45402967538 1382.55900144716 1286.34905790361 0.930411690609339 -0.104058870520171 0.681862445594955 1 8.05041 6.99207 8.08505 5.81115 GeneID:996,Genbank:NM_001353050.1,HGNC:HGNC:1728,MIM:116946 cell division cycle 27 hsa04110,hsa04114,hsa04120,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection CDC34 2227.84487681229 2153.34693682499 2302.34281679959 1.06919269599644 0.0965218872075621 0.578445601300188 1 39.4469 44.3284 44.972 47.9725 GeneID:997,Genbank:XM_006722952.2,HGNC:HGNC:1734,MIM:116948 cell division cycle 34 GO:0000209,GO:0004842,GO:0005524,GO:0005737,GO:0005829,GO:0006513,GO:0007049,GO:0016567,GO:0016607,GO:0031625,GO:0035458,GO:0043161,GO:0043951,GO:0061630,GO:0061631,GO:0070936 protein polyubiquitination|ubiquitin-protein transferase activity|ATP binding|cytoplasm|cytosol|protein monoubiquitination|cell cycle|protein ubiquitination|nuclear speck|ubiquitin protein ligase binding|cellular response to interferon-beta|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of cAMP-mediated signaling|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination hsa04120,hsa05168 Ubiquitin mediated proteolysis|Herpes simplex infection CDC37 5725.27803815616 5611.08565016079 5839.47042615152 1.04070242199639 0.0575576040040813 0.69298277936023 1 95.6755 102.399 103.113 108.307 GeneID:11140,Genbank:XM_011527652.3,HGNC:HGNC:1735,MIM:605065 cell division cycle 37 hsa04151 PI3K-Akt signaling pathway CDC37L1 268.21148442942 286.811146654622 249.611822204218 0.87030028335963 -0.200414828905526 0.342172654705691 1 3.92919 3.71322 3.64521 2.78297 GeneID:55664,Genbank:NM_017913.3,HGNC:HGNC:17179,MIM:610346 cell division cycle 37 like 1 GO:0002576,GO:0005576,GO:0005737,GO:0005829,GO:0006457,GO:0031072,GO:0031089,GO:0050821,GO:0051082,GO:0051087 platelet degranulation|extracellular region|cytoplasm|cytosol|protein folding|heat shock protein binding|platelet dense granule lumen|protein stabilization|unfolded protein binding|chaperone binding CDC40 600.152738877537 595.934238080111 604.371239674964 1.01415760507742 0.0202818716657323 0.886590859016676 1 6.27386 5.73522 6.78646 5.43611 GeneID:51362,Genbank:NM_015891.2,HGNC:HGNC:17350,MIM:605585 cell division cycle 40 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005681,GO:0006369,GO:0006405,GO:0006406,GO:0008380,GO:0031124,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|spliceosomal complex|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|RNA splicing|mRNA 3'-end processing|catalytic step 2 spliceosome hsa03040 Spliceosome CDC42 7269.06983959005 7730.41538514343 6807.72429403667 0.880641460369644 -0.183373327308415 0.163012789660594 1 98.405 101.07 86.8204 92.0121 GeneID:998,Genbank:NM_001039802.1,HGNC:HGNC:1736,MIM:116952 cell division cycle 42 GO:0003924,GO:0005525,GO:0005737,GO:0005815,GO:0006911,GO:0007015,GO:0007264,GO:0016020,GO:0030496,GO:0031258,GO:0032467,GO:0034329,GO:0045198,GO:0051233,GO:0051489,GO:0051491,GO:0051988,GO:0060997,GO:0072686,GO:1900026 GTPase activity|GTP binding|cytoplasm|microtubule organizing center|phagocytosis, engulfment|actin filament organization|small GTPase mediated signal transduction|membrane|midbody|lamellipodium membrane|positive regulation of cytokinesis|cell junction assembly|establishment of epithelial cell apical/basal polarity|spindle midzone|regulation of filopodium assembly|positive regulation of filopodium assembly|regulation of attachment of spindle microtubules to kinetochore|dendritic spine morphogenesis|mitotic spindle|positive regulation of substrate adhesion-dependent cell spreading hsa04010,hsa04014,hsa04015,hsa04062,hsa04144,hsa04360,hsa04370,hsa04510,hsa04520,hsa04530,hsa04660,hsa04666,hsa04670,hsa04722,hsa04810,hsa04912,hsa04932,hsa04933,hsa05100,hsa05120,hsa05130,hsa05131,hsa05132,hsa05165,hsa05200,hsa05203,hsa05205,hsa05211,hsa05212 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Endocytosis|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Tight junction|T cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|GnRH signaling pathway|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Human papillomavirus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Renal cell carcinoma|Pancreatic cancer CDC42BPA 734.351838029684 664.975453825451 803.728222233917 1.20865848146763 0.27340665426766 0.550604550915407 1 2.01705 1.89381 3.16239 1.69131 GeneID:8476,Genbank:XM_017002580.2,HGNC:HGNC:1737,MIM:603412 CDC42 binding protein kinase alpha GO:0000287,GO:0004674,GO:0005524,GO:0005737,GO:0005911,GO:0006468,GO:0016477,GO:0030027,GO:0031032,GO:0031252,GO:0031532,GO:0035556,GO:0042641,GO:0042802,GO:0070062 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|cytoplasm|cell-cell junction|protein phosphorylation|cell migration|lamellipodium|actomyosin structure organization|cell leading edge|actin cytoskeleton reorganization|intracellular signal transduction|actomyosin|identical protein binding|extracellular exosome CDC42BPB 3288.87949156363 3116.40517955008 3461.35380357719 1.11068798957551 0.151453597004716 0.274910338995279 1 13.7932 14.8689 17.0385 15.2323 GeneID:9578,Genbank:NM_006035.3,HGNC:HGNC:1738,MIM:614062 CDC42 binding protein kinase beta CDC42BPG 41.8141471960127 51.648585303408 31.9797090886173 0.619178800363137 -0.691572018002176 0.123831663841898 1 0.365406 0.215119 0.151877 0.231474 GeneID:55561,Genbank:XM_011545156.3,HGNC:HGNC:29829,MIM:613991 CDC42 binding protein kinase gamma GO:0000287,GO:0004674,GO:0005524,GO:0005815,GO:0005829,GO:0006468,GO:0031252,GO:0031532,GO:0035556 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|microtubule organizing center|cytosol|protein phosphorylation|cell leading edge|actin cytoskeleton reorganization|intracellular signal transduction CDC42EP1 2452.76369476531 2612.3425823526 2293.18480717801 0.877826982827357 -0.187991478149681 0.164709047639507 1 37.8306 40.4869 34.3443 36.1151 GeneID:11135,Genbank:XM_006724109.1,HGNC:HGNC:17014,MIM:606084 CDC42 effector protein 1 GO:0005096,GO:0005737,GO:0005856,GO:0005886,GO:0005913,GO:0005925,GO:0007266,GO:0008360,GO:0012505,GO:0017049,GO:0030838,GO:0031274,GO:0098641 GTPase activator activity|cytoplasm|cytoskeleton|plasma membrane|cell-cell adherens junction|focal adhesion|Rho protein signal transduction|regulation of cell shape|endomembrane system|GTP-Rho binding|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|cadherin binding involved in cell-cell adhesion CDC42EP2 94.500937811144 100.328333230603 88.6735423916852 0.883833504817335 -0.178153472326493 0.562549512223876 1 1.92208 2.14629 1.55867 2.17945 GeneID:10435,Genbank:NM_006779.3,HGNC:HGNC:16263,MIM:606132 CDC42 effector protein 2 CDC42EP3 3390.95401527794 3376.20049616383 3405.70753439205 1.00873971740178 0.0125539674519317 0.913501941430893 1 22.166 21.2241 24.2012 19.9594 GeneID:10602,Genbank:NM_001270436.1,HGNC:HGNC:16943,MIM:606133 CDC42 effector protein 3 GO:0005096,GO:0005519,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0007266,GO:0008360,GO:0012505,GO:0015629,GO:0017049,GO:0030838,GO:0031274 GTPase activator activity|cytoskeletal regulatory protein binding|cytoplasm|cytosol|plasma membrane|signal transduction|Rho protein signal transduction|regulation of cell shape|endomembrane system|actin cytoskeleton|GTP-Rho binding|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly CDC42EP4 1954.23987601585 1953.54290065129 1954.9368513804 1.00071355009846 0.00102906808630845 1 1 25.2365 24.7475 25.4571 26.0199 GeneID:23580,Genbank:NM_012121.4,HGNC:HGNC:17147,MIM:605468 CDC42 effector protein 4 GO:0003723,GO:0005096,GO:0005737,GO:0005886,GO:0005913,GO:0007266,GO:0008360,GO:0012505,GO:0015629,GO:0015630,GO:0017049,GO:0030838,GO:0031274,GO:0045335,GO:0071346 RNA binding|GTPase activator activity|cytoplasm|plasma membrane|cell-cell adherens junction|Rho protein signal transduction|regulation of cell shape|endomembrane system|actin cytoskeleton|microtubule cytoskeleton|GTP-Rho binding|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|phagocytic vesicle|cellular response to interferon-gamma CDC42SE1 2683.976689804 2792.16427590136 2575.78910370664 0.922506288737302 -0.116369348810052 0.394207040254109 1 30.3004 31.2323 29.4839 28.501 GeneID:56882,Genbank:NM_020239.3,HGNC:HGNC:17719 CDC42 small effector 1 GO:0005095,GO:0005198,GO:0005737,GO:0005856,GO:0005886,GO:0006909,GO:0007165,GO:0008360 GTPase inhibitor activity|structural molecule activity|cytoplasm|cytoskeleton|plasma membrane|phagocytosis|signal transduction|regulation of cell shape CDC42SE2 698.806741616051 725.387489434299 672.225993797804 0.926712968708691 -0.109805533537552 0.517843910404057 1 10.6134 9.71086 10.4652 8.57464 GeneID:56990,Genbank:NM_020240.2,HGNC:HGNC:18547 CDC42 small effector 2 GO:0001891,GO:0005198,GO:0005737,GO:0005856,GO:0005886,GO:0006909,GO:0008360,GO:0009966,GO:0042995,GO:0070062 phagocytic cup|structural molecule activity|cytoplasm|cytoskeleton|plasma membrane|phagocytosis|regulation of cell shape|regulation of signal transduction|cell projection|extracellular exosome CDC45 1031.17895161164 1044.6688271328 1017.68907609048 0.974173871813167 -0.037748805520409 0.805279171024553 1 13.0254 12.4628 12.7477 13.1391 GeneID:8318,Genbank:XM_011530417.3,HGNC:HGNC:1739,MIM:603465 cell division cycle 45 hsa04110 Cell cycle CDC5L 978.336473438935 987.301047138466 969.371899739404 0.981840242698996 -0.0264397952108544 0.926059591820124 1 5.53296 4.98705 6.03892 4.30687 GeneID:988,Genbank:NM_001253.3,HGNC:HGNC:1743,MIM:602868 cell division cycle 5 like hsa03040 Spliceosome CDC6 2797.21945564358 2798.6106223651 2795.82828892205 0.999005816164345 -0.00143501754331118 0.999138344924033 1 27.8132 28.0943 29.0563 27.8646 GeneID:990,Genbank:XM_011525541.2,HGNC:HGNC:1744,MIM:602627 cell division cycle 6 hsa04110 Cell cycle CDC7 323.977720024235 329.494367898743 318.461072149727 0.966514463299093 -0.0491367732384855 0.891772476185156 1 3.79962 3.49592 4.48085 2.77983 GeneID:8317,Genbank:XM_024450089.1,HGNC:HGNC:1745,MIM:603311 cell division cycle 7 hsa04110 Cell cycle CDC73 645.104676614812 666.416242066 623.793111163625 0.936041278390461 -0.0953559424119061 0.706841468561384 1 4.5627 4.11991 4.61859 3.38362 GeneID:79577,Genbank:NM_024529.4,HGNC:HGNC:16783,MIM:607393 cell division cycle 73 CDCA2 1152.79973588327 1204.39861020216 1101.20086156439 0.914315951742546 -0.129235304608448 0.523719967133271 1 5.93194 5.52317 5.7767 4.43989 GeneID:157313,Genbank:XM_011544417.3,HGNC:HGNC:14623 cell division cycle associated 2 GO:0005654,GO:0005694,GO:0005829,GO:0007049,GO:0035307,GO:0051301 nucleoplasm|chromosome|cytosol|cell cycle|positive regulation of protein dephosphorylation|cell division CDCA3 1224.21277035894 1225.27281773504 1223.15272298284 0.998269695759577 -0.00249846352179739 0.962100928556461 1 18.0205 21.0136 19.3872 20.6515 GeneID:83461,Genbank:NM_001297603.2,HGNC:HGNC:14624,MIM:607749 cell division cycle associated 3 GO:0005829,GO:0005913,GO:0007049,GO:0016567,GO:0051301 cytosol|cell-cell adherens junction|cell cycle|protein ubiquitination|cell division CDCA4 1516.08648012589 1543.89057924221 1488.28238100958 0.963981775016775 -0.0529222236826081 0.690239085907303 1 29.5988 33.9557 31.5121 30.7003 GeneID:55038,Genbank:NM_145701.2,HGNC:HGNC:14625,MIM:612270 cell division cycle associated 4 GO:0005654,GO:0005829,GO:0005886 nucleoplasm|cytosol|plasma membrane CDCA5 2591.16660183383 2602.1941447347 2580.13905893296 0.991524427242924 -0.0122797796918125 0.916842160938088 1 25.3958 26.6975 26.7051 26.1883 GeneID:113130,Genbank:XM_011544743.3,HGNC:HGNC:14626,MIM:609374 cell division cycle associated 5 GO:0000278,GO:0000775,GO:0000790,GO:0003682,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0006302,GO:0007062,GO:0007064,GO:0007076,GO:0007080,GO:0008278,GO:0031536,GO:0051301,GO:0071922 mitotic cell cycle|chromosome, centromeric region|nuclear chromatin|chromatin binding|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|double-strand break repair|sister chromatid cohesion|mitotic sister chromatid cohesion|mitotic chromosome condensation|mitotic metaphase plate congression|cohesin complex|positive regulation of exit from mitosis|cell division|regulation of cohesin loading hsa05206 MicroRNAs in cancer CDCA7 568.604898860256 575.054289895539 562.155507824972 0.977569453359073 -0.0327288896978899 0.858504544593168 1 8.2283 8.03099 8.09354 8.21038 GeneID:83879,Genbank:NM_031942.4,HGNC:HGNC:14628,MIM:609937 cell division cycle associated 7 GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0006915,GO:0042127 nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|regulation of cell proliferation CDCA7L 2932.68581659555 2939.63551626924 2925.73611692186 0.995271726963955 -0.00683763393018341 0.950365474262921 1 30.458 32.733 32.6858 30.8389 GeneID:55536,Genbank:NM_001127371.2,HGNC:HGNC:30777,MIM:609685 cell division cycle associated 7 like GO:0001650,GO:0005634,GO:0005730,GO:0005829,GO:0006351,GO:0006355,GO:0008284 fibrillar center|nucleus|nucleolus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of cell proliferation CDCA8 2638.57178065003 2751.30605309526 2525.8375082048 0.918050358433658 -0.123354801956495 0.369693117490014 1 41.5552 41.5305 38.7847 38.7067 GeneID:55143,Genbank:NM_001256875.1,HGNC:HGNC:14629,MIM:609977 cell division cycle associated 8 GO:0000775,GO:0005730,GO:0005737,GO:0005819,GO:0007049,GO:0032133,GO:0043234,GO:0051301 chromosome, centromeric region|nucleolus|cytoplasm|spindle|cell cycle|chromosome passenger complex|protein complex|cell division CDCP1 1.21723886981142 0.980142803914724 1.45433493570811 1.48379902387637 0.569295696478757 1 1 0 0.0125562 0.00650993 0.00608212 GeneID:64866,Genbank:NM_022842.4,HGNC:HGNC:24357,MIM:611735 CUB domain containing protein 1 GO:0005576,GO:0005886,GO:0016021 extracellular region|plasma membrane|integral component of membrane CDCP2 0.780196841909191 1.07619535328461 0.484198330533773 0.449916763769675 -1.15226997256519 0.981239839765731 1 0 0 0 0.0149105 GeneID:200008,Genbank:NM_001353655.1,HGNC:HGNC:27297,MIM:612320 CUB domain containing protein 2 GO:0005576 extracellular region CDH10 54.9773630533518 46.9497850376821 63.0049410690215 1.34196442046441 0.424346421836147 0.269111223540079 1 0.45823 0.387371 0.645023 0.509169 GeneID:1008,Genbank:NM_001317222.1,HGNC:HGNC:1749,MIM:604555 cadherin 10 GO:0005509,GO:0005886,GO:0007156,GO:0016021,GO:0034332,GO:0098609 calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|adherens junction organization|cell-cell adhesion CDH11 1391.1210332885 1269.04981764095 1513.19224893604 1.19238207035003 0.25384658704053 0.193787956347582 1 5.2655 5.42754 7.46141 5.47051 GeneID:1009,Genbank:NM_001330576.1,HGNC:HGNC:1750,MIM:600023 cadherin 11 GO:0001501,GO:0001503,GO:0005509,GO:0005737,GO:0005886,GO:0007155,GO:0007156,GO:0016021,GO:0021957,GO:0034332,GO:0070062 skeletal system development|ossification|calcium ion binding|cytoplasm|plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|corticospinal tract morphogenesis|adherens junction organization|extracellular exosome CDH12 3.48078688414139 3.084507235799 3.87706653248377 1.25694843166074 0.329925462078687 0.933610977568463 1 0.0146476 0.0206949 0.0280289 0.0261342 GeneID:1010,Genbank:NM_004061.4,HGNC:HGNC:1751,MIM:600562 cadherin 12 GO:0005509,GO:0005886,GO:0007156,GO:0016021,GO:0034332 calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|adherens junction organization CDH13 4057.41290018861 4406.2750764441 3708.55072393311 0.841652111952561 -0.248704061207718 0.0637119905402664 0.897898872552551 27.3786 27.6269 25.4422 21.3681 GeneID:1012,Genbank:NM_001220488.1,HGNC:HGNC:1753,MIM:601364 cadherin 13 CDH15 9.39051796222843 12.4821077672508 6.29892815720603 0.504636578585907 -0.986683311022882 0.324352946632836 1 0.192706 0.10862 0.0737313 0.0829454 GeneID:1013,Genbank:NM_004933.2,HGNC:HGNC:1754,MIM:114019 cadherin 15 GO:0005509,GO:0005794,GO:0005829,GO:0005886,GO:0005901,GO:0007155,GO:0007156,GO:0016021,GO:0031594,GO:0034332,GO:0051149,GO:0070062 calcium ion binding|Golgi apparatus|cytosol|plasma membrane|caveola|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|neuromuscular junction|adherens junction organization|positive regulation of muscle cell differentiation|extracellular exosome hsa04514 Cell adhesion molecules (CAMs) CDH16 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:1014,Genbank:NM_001204746.1,HGNC:HGNC:1755,MIM:603118 cadherin 16 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399,GO:0016323,GO:0016339,GO:0070062 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|basolateral plasma membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|extracellular exosome CDH18 2.2370333273024 1.56626675524197 2.90779989936283 1.85651638817655 0.892598050466924 0.765300490057989 1 0.00946065 0 0.00909537 0.012697 GeneID:1016,Genbank:NM_001349562.1,HGNC:HGNC:1757,MIM:603019 cadherin 18 GO:0005509,GO:0005886,GO:0007156,GO:0016021,GO:0034332 calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|adherens junction organization CDH19 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.011967 0 0 GeneID:28513,Genbank:XM_011525931.3,HGNC:HGNC:1758,MIM:603016 cadherin 19 GO:0005509,GO:0005886,GO:0007156,GO:0016021 calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane CDH2 3780.21164937966 3640.52721025906 3919.89608850025 1.07673857716375 0.10666801848887 0.421249718585187 1 25.7856 25.0848 30.2485 24.9501 GeneID:1000,Genbank:XM_017025514.2,HGNC:HGNC:1759,MIM:114020 cadherin 2 GO:0005509,GO:0005737,GO:0005788,GO:0005886,GO:0005911,GO:0005913,GO:0005916,GO:0005925,GO:0007155,GO:0007156,GO:0007157,GO:0008013,GO:0009986,GO:0010001,GO:0014069,GO:0014704,GO:0016021,GO:0016323,GO:0016324,GO:0016339,GO:0016342,GO:0016477,GO:0019901,GO:0019903,GO:0021987,GO:0030027,GO:0030054,GO:0031012,GO:0034332,GO:0042383,GO:0042802,GO:0043410,GO:0043687,GO:0044267,GO:0044331,GO:0044853,GO:0045294,GO:0045295,GO:0048514,GO:0048854,GO:0048872,GO:0051146,GO:0051149,GO:0060019,GO:0060563,GO:0070062,GO:0070445,GO:0072659,GO:0090090,GO:0097118,GO:0097150,GO:1902897,GO:2000809 calcium ion binding|cytoplasm|endoplasmic reticulum lumen|plasma membrane|cell-cell junction|cell-cell adherens junction|fascia adherens|focal adhesion|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|beta-catenin binding|cell surface|glial cell differentiation|postsynaptic density|intercalated disc|integral component of membrane|basolateral plasma membrane|apical plasma membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|catenin complex|cell migration|protein kinase binding|protein phosphatase binding|cerebral cortex development|lamellipodium|cell junction|extracellular matrix|adherens junction organization|sarcolemma|identical protein binding|positive regulation of MAPK cascade|post-translational protein modification|cellular protein metabolic process|cell-cell adhesion mediated by cadherin|plasma membrane raft|alpha-catenin binding|gamma-catenin binding|blood vessel morphogenesis|brain morphogenesis|homeostasis of number of cells|striated muscle cell differentiation|positive regulation of muscle cell differentiation|radial glial cell differentiation|neuroepithelial cell differentiation|extracellular exosome|regulation of oligodendrocyte progenitor proliferation|protein localization to plasma membrane|negative regulation of canonical Wnt signaling pathway|neuroligin clustering involved in postsynaptic membrane assembly|neuronal stem cell population maintenance|regulation of postsynaptic density protein 95 clustering|positive regulation of synaptic vesicle clustering hsa04514,hsa05412 Cell adhesion molecules (CAMs)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) CDH20 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00368091 0 0.00351414 0 GeneID:28316,Genbank:NM_031891.3,HGNC:HGNC:1760,MIM:605807 cadherin 20 GO:0005509,GO:0005886,GO:0007156,GO:0016021 calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane CDH22 0.972638154859436 0.490071401957362 1.45520490776151 2.96937324224464 1.5701584476161 0.837389832160054 1 0 0 0.0102443 0 GeneID:64405,Genbank:NM_021248.2,HGNC:HGNC:13251,MIM:609920 cadherin 22 GO:0005509,GO:0005886,GO:0007156,GO:0007420,GO:0016021,GO:0016339 calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|brain development|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules CDH23 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00233287 0 0 GeneID:64072,Genbank:NM_022124.5,HGNC:HGNC:13733,MIM:605516 cadherin related 23 GO:0001917,GO:0005509,GO:0005813,GO:0005886,GO:0006816,GO:0007156,GO:0007605,GO:0007626,GO:0016021,GO:0032420,GO:0032426,GO:0042472,GO:0042491,GO:0045177,GO:0045202,GO:0045494,GO:0047485,GO:0048563,GO:0048839,GO:0050953,GO:0050957,GO:0051480,GO:0060088,GO:0060091,GO:0060122 photoreceptor inner segment|calcium ion binding|centrosome|plasma membrane|calcium ion transport|homophilic cell adhesion via plasma membrane adhesion molecules|sensory perception of sound|locomotory behavior|integral component of membrane|stereocilium|stereocilium tip|inner ear morphogenesis|inner ear auditory receptor cell differentiation|apical part of cell|synapse|photoreceptor cell maintenance|protein N-terminus binding|post-embryonic animal organ morphogenesis|inner ear development|sensory perception of light stimulus|equilibrioception|regulation of cytosolic calcium ion concentration|auditory receptor cell stereocilium organization|kinocilium|inner ear receptor cell stereocilium organization CDH24 540.372650334002 543.306526973643 537.438773694361 0.989199921245256 -0.0156659700190778 0.921155679669364 1 4.43297 4.37895 4.32682 4.50691 GeneID:64403,Genbank:NM_144985.3,HGNC:HGNC:14265 cadherin 24 GO:0005509,GO:0005886,GO:0005911,GO:0007156,GO:0008013,GO:0016021,GO:0034332,GO:0045294,GO:0070097,GO:0098609 calcium ion binding|plasma membrane|cell-cell junction|homophilic cell adhesion via plasma membrane adhesion molecules|beta-catenin binding|integral component of membrane|adherens junction organization|alpha-catenin binding|delta-catenin binding|cell-cell adhesion CDH26 2.24247141269929 2.54640955915669 1.93853326624189 0.76128101988585 -0.393498985236256 0.964560642378451 1 0 0.00371213 0 0.00352829 GeneID:60437,Genbank:XM_017027995.2,HGNC:HGNC:15902,MIM:617685 cadherin 26 GO:0005509,GO:0005886,GO:0007156,GO:0016021 calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane CDH3 2.6951519568353 1.02816907859967 4.36213483507094 4.24262402542978 2.08495683496113 0.348083628734939 1 0.00828606 0.00735547 0.0232898 0.0217685 GeneID:1001,Genbank:NM_001317195.1,HGNC:HGNC:1762,MIM:114021 cadherin 3 hsa04514 Cell adhesion molecules (CAMs) CDH4 4569.19005043441 4431.91674482847 4706.46335604035 1.06194760123422 0.0867125822394937 0.534677473516835 1 22.4719 23.985 27.0873 23.2972 GeneID:1002,Genbank:NM_001794.4,HGNC:HGNC:1763,MIM:603006 cadherin 4 GO:0005509,GO:0005886,GO:0005887,GO:0007155,GO:0007156,GO:0007157,GO:0007411,GO:0034332,GO:0045773 calcium ion binding|plasma membrane|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|axon guidance|adherens junction organization|positive regulation of axon extension hsa04514 Cell adhesion molecules (CAMs) CDH5 218.985054648006 263.038796332991 174.931312963022 0.66503996901495 -0.588487045451216 0.0074314203239754 0.341036183119742 1.69858 1.8842 1.13097 1.28736 GeneID:1003,Genbank:NM_001795.4,HGNC:HGNC:1764,MIM:601120 cadherin 5 GO:0001955,GO:0005102,GO:0005509,GO:0005886,GO:0005911,GO:0005913,GO:0005923,GO:0007043,GO:0007156,GO:0007179,GO:0008013,GO:0008285,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0019903,GO:0030054,GO:0034332,GO:0044325,GO:0050728,GO:1903142,GO:2000114 blood vessel maturation|receptor binding|calcium ion binding|plasma membrane|cell-cell junction|cell-cell adherens junction|bicellular tight junction|cell-cell junction assembly|homophilic cell adhesion via plasma membrane adhesion molecules|transforming growth factor beta receptor signaling pathway|beta-catenin binding|negative regulation of cell proliferation|external side of plasma membrane|cell surface|membrane|integral component of membrane|protein phosphatase binding|cell junction|adherens junction organization|ion channel binding|negative regulation of inflammatory response|positive regulation of establishment of endothelial barrier|regulation of establishment of cell polarity hsa04514,hsa04670,hsa05418 Cell adhesion molecules (CAMs)|Leukocyte transendothelial migration|Fluid shear stress and atherosclerosis CDH6 151.227517233807 133.767841422434 168.68719304518 1.26104444275565 0.334619121196131 0.380674650714893 1 0.447433 0.469415 0.740834 0.429994 GeneID:1004,Genbank:NM_004932.3,HGNC:HGNC:1765,MIM:603007 cadherin 6 GO:0005509,GO:0005886,GO:0007155,GO:0007156,GO:0007219,GO:0016021,GO:0034332,GO:0070062 calcium ion binding|plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|Notch signaling pathway|integral component of membrane|adherens junction organization|extracellular exosome CDH7 2.50651715165025 2.10436443188427 2.90866987141623 1.38220824651164 0.466974991685868 0.907564573450322 1 0.0142356 0.0045533 0.0137161 0.00849925 GeneID:1005,Genbank:NM_033646.2,HGNC:HGNC:1766,MIM:605806 cadherin 7 GO:0005509,GO:0005886,GO:0007156,GO:0016021,GO:0034332,GO:0098609 calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|adherens junction organization|cell-cell adhesion CDH8 0.968831647094244 0 1.93766329418849 Inf Inf 0.451925900856321 1 0 0 0.0031309 0.00872012 GeneID:1006,Genbank:XM_005255760.4,HGNC:HGNC:1767,MIM:603008 cadherin 8 GO:0005509,GO:0005886,GO:0007155,GO:0007156,GO:0009409,GO:0016021,GO:0034332,GO:0035249,GO:0042802,GO:0043083,GO:0043679 calcium ion binding|plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|response to cold|integral component of membrane|adherens junction organization|synaptic transmission, glutamatergic|identical protein binding|synaptic cleft|axon terminus CDHR1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00483416 0 0 0 GeneID:92211,Genbank:NM_001171971.2,HGNC:HGNC:14550,MIM:609502 cadherin related family member 1 GO:0005509,GO:0005887,GO:0007156,GO:0008594,GO:0035845,GO:0042622,GO:0045494 calcium ion binding|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|photoreceptor cell morphogenesis|photoreceptor cell outer segment organization|photoreceptor outer segment membrane|photoreceptor cell maintenance CDHR2 0.969701619147642 0 1.93940323829528 Inf Inf 0.451735954600221 1 0 0 0.0162919 0.00762444 GeneID:54825,Genbank:NM_001171976.1,HGNC:HGNC:18231 cadherin related family member 2 CDHR3 22.1524021334084 23.9458551110099 20.3589491558068 0.850207648105499 -0.234112857982437 0.713244677180558 1 0.0441991 0.0462806 0.0526731 0.0294586 GeneID:222256,Genbank:XM_017011863.2,HGNC:HGNC:26308,MIM:615610 cadherin related family member 3 GO:0001618,GO:0005509,GO:0005886,GO:0007156,GO:0016021 virus receptor activity|calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane CDHR4 0.807146514963456 1.61429302992691 0 0 -Inf 0.549240155942477 1 0 0 0 0 GeneID:389118,Genbank:XM_011533701.2,HGNC:HGNC:34527 cadherin related family member 4 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development CDHR5 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0 0 0 0 GeneID:53841,Genbank:NM_031264.3,HGNC:HGNC:7521,MIM:606839 cadherin related family member 5 CDIP1 23.8140327918685 18.0649982875216 29.5630672962155 1.63648326037408 0.710598845096506 0.221941643808574 1 0.330171 0.191296 0.46008 0.414439 GeneID:29965,Genbank:NM_001199056.1,HGNC:HGNC:13234,MIM:610503 cell death inducing p53 target 1 GO:0005634,GO:0006915,GO:0033209,GO:0042771,GO:0046872,GO:0098560,GO:0098574 nucleus|apoptotic process|tumor necrosis factor-mediated signaling pathway|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|metal ion binding|cytoplasmic side of late endosome membrane|cytoplasmic side of lysosomal membrane CDIPT 1028.18933369662 828.330892809814 1228.04777458343 1.48255701343907 0.568087586339048 0.00020764760428851 0.0361487394596172 16.2483 17.1263 26.8063 25.8427 GeneID:10423,Genbank:NM_001286585.1,HGNC:HGNC:1769,MIM:605893 CDP-diacylglycerol--inositol 3-phosphatidyltransferase GO:0000139,GO:0003881,GO:0005789,GO:0005794,GO:0005886,GO:0006661,GO:0016020,GO:0016021,GO:0019992,GO:0030145,GO:0030246,GO:0043178,GO:0046341 Golgi membrane|CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|phosphatidylinositol biosynthetic process|membrane|integral component of membrane|diacylglycerol binding|manganese ion binding|carbohydrate binding|alcohol binding|CDP-diacylglycerol metabolic process hsa00562,hsa00564,hsa04070 Inositol phosphate metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system CDK1 2922.46138295616 3176.03186710288 2668.89089880945 0.840322455972071 -0.250985057038844 0.0718821497887357 0.928200388965456 28.5951 27.0056 25.2322 22.7284 GeneID:983,Genbank:NM_001320918.1,HGNC:HGNC:1722,MIM:116940 cyclin dependent kinase 1 hsa04110,hsa04114,hsa04115,hsa04218,hsa04540,hsa04914,hsa05168,hsa05170,hsa05203 Cell cycle|Oocyte meiosis|p53 signaling pathway|Cellular senescence|Gap junction|Progesterone-mediated oocyte maturation|Herpes simplex infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis CDK10 606.887394793597 603.632318688229 610.142470898966 1.01078496298025 0.0154761071919403 0.944878725315757 1 6.38689 6.6838 6.91901 6.9741 GeneID:8558,Genbank:XM_017023806.1,HGNC:HGNC:1770,MIM:603464 cyclin dependent kinase 10 GO:0004674,GO:0004693,GO:0005524,GO:0005737,GO:0006468,GO:0007089,GO:0008285,GO:0016592,GO:0018107,GO:0030030,GO:0032956,GO:0036064,GO:0043410,GO:1902018 protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation|traversing start control point of mitotic cell cycle|negative regulation of cell proliferation|mediator complex|peptidyl-threonine phosphorylation|cell projection organization|regulation of actin cytoskeleton organization|ciliary basal body|positive regulation of MAPK cascade|negative regulation of cilium assembly CDK11A 404.271084761553 392.261724968862 416.280444554244 1.06123136175799 0.0857392161712996 0.663055198754341 1 2.05132 2.40829 2.50346 2.30289 GeneID:728642,Genbank:NM_033529.3,HGNC:HGNC:1730,MIM:116951 cyclin dependent kinase 11A GO:0000278,GO:0001558,GO:0004672,GO:0004674,GO:0004693,GO:0005524,GO:0005634,GO:0005737,GO:0006355,GO:0006468,GO:0006915,GO:0007346,GO:0050684 mitotic cell cycle|regulation of cell growth|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|regulation of mitotic cell cycle|regulation of mRNA processing CDK11B 1551.78298470352 1500.03307609372 1603.53289331331 1.06899835668232 0.096259635277213 0.508934256653513 1 8.17052 8.33717 8.51375 8.065 GeneID:984,Genbank:XM_017002927.2,HGNC:HGNC:1729,MIM:176873 cyclin dependent kinase 11B GO:0000278,GO:0001558,GO:0004672,GO:0004674,GO:0004693,GO:0005524,GO:0005634,GO:0005737,GO:0006355,GO:0006468,GO:0006915,GO:0007346,GO:0050684 mitotic cell cycle|regulation of cell growth|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|regulation of mitotic cell cycle|regulation of mRNA processing CDK12 1700.08323779332 1667.84514996868 1732.32132561797 1.03865837044315 0.0547212092814439 0.812687060323139 1 4.18106 4.19335 5.28841 3.58196 GeneID:51755,Genbank:XM_011524896.2,HGNC:HGNC:24224,MIM:615514 cyclin dependent kinase 12 GO:0001650,GO:0002944,GO:0004672,GO:0004693,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0006368,GO:0006397,GO:0008024,GO:0008134,GO:0008353,GO:0008380,GO:0016607,GO:0019901,GO:0019908,GO:0030332,GO:0043405,GO:0043484,GO:0044212,GO:0045944,GO:0046777,GO:0070816,GO:2000737 fibrillar center|cyclin K-CDK12 complex|protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|chromosome|transcription elongation from RNA polymerase II promoter|mRNA processing|cyclin/CDK positive transcription elongation factor complex|transcription factor binding|RNA polymerase II carboxy-terminal domain kinase activity|RNA splicing|nuclear speck|protein kinase binding|nuclear cyclin-dependent protein kinase holoenzyme complex|cyclin binding|regulation of MAP kinase activity|regulation of RNA splicing|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|phosphorylation of RNA polymerase II C-terminal domain|negative regulation of stem cell differentiation CDK13 1251.02952918442 1282.66595569128 1219.39310267756 0.950670825297131 -0.0729822079760747 0.624622700797126 1 5.28099 5.48933 5.7535 4.83658 GeneID:8621,Genbank:XM_017012750.2,HGNC:HGNC:1733,MIM:603309 cyclin dependent kinase 13 CDK14 671.636664748874 520.301580046116 822.971749451632 1.5817206424372 0.661494818926368 6.52194231448888e-05 0.0186527550194382 1.21169 1.17705 2.06497 1.65718 GeneID:5218,Genbank:XM_011516306.3,HGNC:HGNC:8883,MIM:610679 cyclin dependent kinase 14 GO:0000086,GO:0000308,GO:0004693,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0016055,GO:0030332,GO:0051301,GO:0060828 G2/M transition of mitotic cell cycle|cytoplasmic cyclin-dependent protein kinase holoenzyme complex|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|Wnt signaling pathway|cyclin binding|cell division|regulation of canonical Wnt signaling pathway hsa05202 Transcriptional misregulation in cancer CDK15 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00412905 0 0 0 GeneID:65061,Genbank:XM_005246782.4,HGNC:HGNC:14434,MIM:616147 cyclin dependent kinase 15 GO:0004674,GO:0004693,GO:0005524,GO:0005634,GO:0005829,GO:0030332,GO:0046872 protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytosol|cyclin binding|metal ion binding CDK16 2893.88392792726 2443.82668066502 3343.94117518949 1.36832173969044 0.452407497533841 0.000991970265779994 0.103164907641119 15.2439 15.5942 22.2046 21.2625 GeneID:5127,Genbank:XM_017029573.1,HGNC:HGNC:8749,MIM:311550 cyclin dependent kinase 16 GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006887,GO:0007283,GO:0008021,GO:0015630,GO:0030054,GO:0030252,GO:0031175,GO:0031234,GO:0043005,GO:0061178 protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|exocytosis|spermatogenesis|synaptic vesicle|microtubule cytoskeleton|cell junction|growth hormone secretion|neuron projection development|extrinsic component of cytoplasmic side of plasma membrane|neuron projection|regulation of insulin secretion involved in cellular response to glucose stimulus CDK17 335.215781230734 356.332625146812 314.098937314656 0.881476786430221 -0.182005518016864 0.534589627792222 1 3.0113 2.72532 3.19231 2.0454 GeneID:5128,Genbank:NM_002595.4,HGNC:HGNC:8750,MIM:603440 cyclin dependent kinase 17 GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468 protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation CDK18 51.9102807997271 48.0838153207596 55.7367462786945 1.15915814722445 0.213077410737488 0.615524513690143 1 0.399362 0.467376 0.474731 0.483803 GeneID:5129,Genbank:NM_002596.3,HGNC:HGNC:8751,MIM:169190 cyclin dependent kinase 18 GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468 protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation CDK19 452.252089779454 474.120215403393 430.383964155514 0.90775282338327 -0.139628582641051 0.454416589456776 1 2.06615 1.84776 2.02907 1.63927 GeneID:23097,Genbank:XM_011535630.2,HGNC:HGNC:19338,MIM:614720 cyclin dependent kinase 19 GO:0004693,GO:0005524,GO:0005634,GO:0005829,GO:0006468,GO:0007346,GO:0019899,GO:0043065,GO:0050729,GO:0071222 cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytosol|protein phosphorylation|regulation of mitotic cell cycle|enzyme binding|positive regulation of apoptotic process|positive regulation of inflammatory response|cellular response to lipopolysaccharide CDK2 2974.64878784684 3001.7873234227 2947.51025227097 0.981918415495924 -0.0263249343484469 0.834908086544718 1 46.8629 50.9263 50.1329 47.9916 GeneID:1017,Genbank:NM_001798.4,HGNC:HGNC:1771,MIM:116953 cyclin dependent kinase 2 GO:0000082,GO:0000122,GO:0000307,GO:0000781,GO:0000793,GO:0000805,GO:0000806,GO:0004672,GO:0004693,GO:0005524,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005768,GO:0005813,GO:0006281,GO:0006468,GO:0006813,GO:0007099,GO:0007165,GO:0007265,GO:0007275,GO:0008284,GO:0010033,GO:0010389,GO:0015030,GO:0016301,GO:0016572,GO:0018105,GO:0019904,GO:0030332,GO:0032298,GO:0035173,GO:0045893,GO:0046872,GO:0051301,GO:0051321,GO:0060968,GO:0097123,GO:0097124,GO:0097134,GO:0097135,GO:0097472 G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|cyclin-dependent protein kinase holoenzyme complex|chromosome, telomeric region|condensed chromosome|X chromosome|Y chromosome|protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|transcription factor complex|cytoplasm|endosome|centrosome|DNA repair|protein phosphorylation|potassium ion transport|centriole replication|signal transduction|Ras protein signal transduction|multicellular organism development|positive regulation of cell proliferation|response to organic substance|regulation of G2/M transition of mitotic cell cycle|Cajal body|kinase activity|histone phosphorylation|peptidyl-serine phosphorylation|protein domain specific binding|cyclin binding|positive regulation of DNA-dependent DNA replication initiation|histone kinase activity|positive regulation of transcription, DNA-templated|metal ion binding|cell division|meiotic cell cycle|regulation of gene silencing|cyclin A1-CDK2 complex|cyclin A2-CDK2 complex|cyclin E1-CDK2 complex|cyclin E2-CDK2 complex|cyclin-dependent protein kinase activity hsa04068,hsa04110,hsa04114,hsa04115,hsa04151,hsa04218,hsa04914,hsa04934,hsa05161,hsa05162,hsa05165,hsa05168,hsa05169,hsa05200,hsa05203,hsa05215,hsa05222,hsa05226 FoxO signaling pathway|Cell cycle|Oocyte meiosis|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Progesterone-mediated oocyte maturation|Cushing syndrome|Hepatitis B|Measles|Human papillomavirus infection|Herpes simplex infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Prostate cancer|Small cell lung cancer|Gastric cancer CDK20 189.552649738346 192.51755772667 186.587741750022 0.969198570526916 -0.0451358179305943 0.861161368040668 1 2.31325 2.2187 2.37937 2.27915 GeneID:23552,Genbank:NM_001170640.1,HGNC:HGNC:21420,MIM:610076 cyclin dependent kinase 20 GO:0004693,GO:0005524,GO:0005634,GO:0005737,GO:0005929,GO:0007049,GO:0007275,GO:0019912,GO:0051301,GO:1904031 cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cilium|cell cycle|multicellular organism development|cyclin-dependent protein kinase activating kinase activity|cell division|positive regulation of cyclin-dependent protein kinase activity CDK2AP1 4986.75178755666 4794.27125462026 5179.23232049306 1.08029605448415 0.111426736282529 0.405656191588258 1 161.459 160.868 176.88 168.897 GeneID:8099,Genbank:NM_004642.3,HGNC:HGNC:14002,MIM:602198 cyclin dependent kinase 2 associated protein 1 GO:0001934,GO:0005634,GO:0005654,GO:0005829,GO:0006261,GO:0007049,GO:0048471,GO:0070182 positive regulation of protein phosphorylation|nucleus|nucleoplasm|cytosol|DNA-dependent DNA replication|cell cycle|perinuclear region of cytoplasm|DNA polymerase binding CDK2AP2 809.390747249259 828.378919084499 790.40257541402 0.954155830386836 -0.0677031920033974 0.658344224381941 1 21.4963 21.458 20.3704 21.692 GeneID:10263,Genbank:NM_005851.4,HGNC:HGNC:30833 cyclin dependent kinase 2 associated protein 2 GO:0005634,GO:0005737,GO:0005874,GO:0070507,GO:2000035,GO:2000134 nucleus|cytoplasm|microtubule|regulation of microtubule cytoskeleton organization|regulation of stem cell division|negative regulation of G1/S transition of mitotic cell cycle CDK3 83.6949845558643 84.5215868541283 82.8683822576003 0.980440445357691 -0.0284980950630553 0.921953749381048 1 1.29305 1.78596 1.23034 1.42488 GeneID:1018,Genbank:NM_001258.2,HGNC:HGNC:1772,MIM:123828 cyclin dependent kinase 3 CDK4 4346.11296661026 4444.22433080548 4248.00160241504 0.955847699444354 -0.065147331033109 0.614073680704445 1 82.1444 87.9308 79.2969 85.1855 GeneID:1019,Genbank:NM_000075.3,HGNC:HGNC:1773,MIM:123829 cyclin dependent kinase 4 hsa01522,hsa04110,hsa04115,hsa04151,hsa04218,hsa04530,hsa04660,hsa04933,hsa04934,hsa05161,hsa05162,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05203,hsa05212,hsa05214,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225 Endocrine resistance|Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Tight junction|T cell receptor signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Hepatitis B|Measles|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer|Glioma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma CDK5 1160.28676791256 1149.27353281207 1171.30000301306 1.0191655594357 0.0273884306750072 0.86589396109597 1 34.6452 34.7095 34.3209 35.2322 GeneID:1020,Genbank:NM_001164410.2,HGNC:HGNC:1774,MIM:123831 cyclin dependent kinase 5 GO:0000226,GO:0001764,GO:0001963,GO:0002039,GO:0004672,GO:0004674,GO:0004693,GO:0005176,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0005886,GO:0006468,GO:0006886,GO:0006913,GO:0007049,GO:0007160,GO:0007268,GO:0007416,GO:0007519,GO:0008045,GO:0008092,GO:0008283,GO:0008542,GO:0009611,GO:0014044,GO:0014069,GO:0016020,GO:0016079,GO:0016241,GO:0016301,GO:0016310,GO:0016533,GO:0018105,GO:0018107,GO:0019233,GO:0019901,GO:0021697,GO:0021766,GO:0021819,GO:0021954,GO:0022038,GO:0030027,GO:0030054,GO:0030175,GO:0030182,GO:0030334,GO:0030424,GO:0030425,GO:0030426,GO:0030517,GO:0030549,GO:0030866,GO:0031175,GO:0031397,GO:0031594,GO:0031914,GO:0032092,GO:0032801,GO:0035249,GO:0035418,GO:0042501,GO:0042981,GO:0043025,GO:0043113,GO:0043125,GO:0043204,GO:0043525,GO:0045211,GO:0045786,GO:0045860,GO:0045861,GO:0045892,GO:0045956,GO:0046777,GO:0046826,GO:0046875,GO:0048148,GO:0048167,GO:0048488,GO:0048511,GO:0048675,GO:0048709,GO:0048813,GO:0050321,GO:0051301,GO:0051402,GO:0051966,GO:0060079,GO:0061001,GO:0070509,GO:0071156,GO:0090314,GO:0098793,GO:1901215,GO:1901796,GO:1903076,GO:1903421,GO:1904646,GO:2000251 microtubule cytoskeleton organization|neuron migration|synaptic transmission, dopaminergic|p53 binding|protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ErbB-2 class receptor binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|microtubule|plasma membrane|protein phosphorylation|intracellular protein transport|nucleocytoplasmic transport|cell cycle|cell-matrix adhesion|chemical synaptic transmission|synapse assembly|skeletal muscle tissue development|motor neuron axon guidance|cytoskeletal protein binding|cell proliferation|visual learning|response to wounding|Schwann cell development|postsynaptic density|membrane|synaptic vesicle exocytosis|regulation of macroautophagy|kinase activity|phosphorylation|cyclin-dependent protein kinase 5 holoenzyme complex|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sensory perception of pain|protein kinase binding|cerebellar cortex formation|hippocampus development|layer formation in cerebral cortex|central nervous system neuron development|corpus callosum development|lamellipodium|cell junction|filopodium|neuron differentiation|regulation of cell migration|axon|dendrite|growth cone|negative regulation of axon extension|acetylcholine receptor activator activity|cortical actin cytoskeleton organization|neuron projection development|negative regulation of protein ubiquitination|neuromuscular junction|negative regulation of synaptic plasticity|positive regulation of protein binding|receptor catabolic process|synaptic transmission, glutamatergic|protein localization to synapse|serine phosphorylation of STAT protein|regulation of apoptotic process|neuronal cell body|receptor clustering|ErbB-3 class receptor binding|perikaryon|positive regulation of neuron apoptotic process|postsynaptic membrane|negative regulation of cell cycle|positive regulation of protein kinase activity|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of calcium ion-dependent exocytosis|protein autophosphorylation|negative regulation of protein export from nucleus|ephrin receptor binding|behavioral response to cocaine|regulation of synaptic plasticity|synaptic vesicle endocytosis|rhythmic process|axon extension|oligodendrocyte differentiation|dendrite morphogenesis|tau-protein kinase activity|cell division|neuron apoptotic process|regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|regulation of dendritic spine morphogenesis|calcium ion import|regulation of cell cycle arrest|positive regulation of protein targeting to membrane|presynapse|negative regulation of neuron death|regulation of signal transduction by p53 class mediator|regulation of protein localization to plasma membrane|regulation of synaptic vesicle recycling|cellular response to amyloid-beta|positive regulation of actin cytoskeleton reorganization hsa04360,hsa05010,hsa05030 Axon guidance|Alzheimer disease|Cocaine addiction CDK5R1 209.815101138894 220.912273074873 198.717929202915 0.899533223921713 -0.152751527027161 0.507302028907763 1 2.04649 1.92602 2.1005 1.57162 GeneID:8851,Genbank:XM_017025281.2,HGNC:HGNC:1775,MIM:603460 cyclin dependent kinase 5 regulatory subunit 1 hsa05010,hsa05030 Alzheimer disease|Cocaine addiction CDK5R2 7.15020857346782 5.09281911831339 9.20759802862226 1.80795701059015 0.854360373911425 0.472947526524967 1 0.11559 0.145807 0.237438 0.24727 GeneID:8941,Genbank:NM_003936.4,HGNC:HGNC:1776,MIM:603764 cyclin dependent kinase 5 regulatory subunit 2 CDK5RAP1 828.831805067515 825.58256949681 832.08104063822 1.00787137638501 0.0113115351753461 0.958570532929685 1 5.79927 6.49133 6.3863 6.22633 GeneID:51654,Genbank:XM_011528856.3,HGNC:HGNC:15880,MIM:608200 CDK5 regulatory subunit associated protein 1 GO:0005739,GO:0007420,GO:0019901,GO:0032403,GO:0035597,GO:0045664,GO:0045736,GO:0045903,GO:0046872,GO:0051539,GO:0070131,GO:0070900 mitochondrion|brain development|protein kinase binding|protein complex binding|N6-isopentenyladenosine methylthiotransferase activity|regulation of neuron differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of translational fidelity|metal ion binding|4 iron, 4 sulfur cluster binding|positive regulation of mitochondrial translation|mitochondrial tRNA modification CDK5RAP2 1059.20731734336 1076.91545311091 1041.49918157581 0.967113229332178 -0.048243284985823 0.775228772972869 1 4.68527 4.24653 4.6037 4.12191 GeneID:55755,Genbank:NM_001272039.1,HGNC:HGNC:18672,MIM:608201 CDK5 regulatory subunit associated protein 2 GO:0000086,GO:0000132,GO:0000226,GO:0000242,GO:0000922,GO:0001578,GO:0005516,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005856,GO:0005874,GO:0007059,GO:0007098,GO:0007099,GO:0007420,GO:0008017,GO:0010389,GO:0015631,GO:0019901,GO:0022008,GO:0030054,GO:0031023,GO:0035371,GO:0044212,GO:0045664,GO:0045665,GO:0045893,GO:0046600,GO:0048471,GO:0070062,GO:0090231,GO:0097431,GO:0097711 G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|microtubule cytoskeleton organization|pericentriolar material|spindle pole|microtubule bundle formation|calmodulin binding|cytoplasm|Golgi apparatus|centrosome|cytosol|cytoskeleton|microtubule|chromosome segregation|centrosome cycle|centriole replication|brain development|microtubule binding|regulation of G2/M transition of mitotic cell cycle|tubulin binding|protein kinase binding|neurogenesis|cell junction|microtubule organizing center organization|microtubule plus-end|transcription regulatory region DNA binding|regulation of neuron differentiation|negative regulation of neuron differentiation|positive regulation of transcription, DNA-templated|negative regulation of centriole replication|perinuclear region of cytoplasm|extracellular exosome|regulation of spindle checkpoint|mitotic spindle pole|ciliary basal body-plasma membrane docking CDK5RAP3 1543.64268718219 1423.63098066391 1663.65439370047 1.16859945891639 0.22478052640071 0.118931455679552 1 12.4665 12.3462 14.2731 14.9713 GeneID:80279,Genbank:XM_011525297.1,HGNC:HGNC:18673,MIM:608202 CDK5 regulatory subunit associated protein 3 GO:0000079,GO:0001933,GO:0005634,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0007095,GO:0007420,GO:0008283,GO:0010921,GO:0012505,GO:0016020,GO:0019901,GO:0030262,GO:0030332,GO:0030968,GO:0031398,GO:0032088,GO:0043234,GO:0043407,GO:0044387,GO:0044389,GO:0044818,GO:0045664,GO:0045944,GO:0051019,GO:0051059,GO:0071569,GO:0071901,GO:0097371,GO:1900182,GO:1901798,GO:1903363 regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of protein phosphorylation|nucleus|nucleolus|cytoplasm|centrosome|cytosol|mitotic G2 DNA damage checkpoint|brain development|cell proliferation|regulation of phosphatase activity|endomembrane system|membrane|protein kinase binding|apoptotic nuclear changes|cyclin binding|endoplasmic reticulum unfolded protein response|positive regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|protein complex|negative regulation of MAP kinase activity|negative regulation of protein kinase activity by regulation of protein phosphorylation|ubiquitin-like protein ligase binding|mitotic G2/M transition checkpoint|regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|mitogen-activated protein kinase binding|NF-kappaB binding|protein ufmylation|negative regulation of protein serine/threonine kinase activity|MDM2/MDM4 family protein binding|positive regulation of protein localization to nucleus|positive regulation of signal transduction by p53 class mediator|negative regulation of cellular protein catabolic process CDK6 1079.81796330052 934.086195079816 1225.54973152122 1.31203066481086 0.391801439051706 0.515174802728547 1 3.94511 3.4984 6.85393 3.054 GeneID:1021,Genbank:NM_001145306.1,HGNC:HGNC:1777,MIM:603368 cyclin dependent kinase 6 hsa04110,hsa04115,hsa04151,hsa04218,hsa04934,hsa05161,hsa05162,hsa05163,hsa05165,hsa05167,hsa05169,hsa05200,hsa05203,hsa05206,hsa05212,hsa05214,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225 Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Cushing syndrome|Hepatitis B|Measles|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Pancreatic cancer|Glioma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma CDK7 660.782052670588 713.828706542025 607.735398799152 0.851374276811005 -0.232134593301709 0.156799268908671 1 12.4101 13.3393 11.3386 10.2222 GeneID:1022,Genbank:NM_001324069.1,HGNC:HGNC:1778,MIM:601955 cyclin dependent kinase 7 hsa03022,hsa03420,hsa04110 Basal transcription factors|Nucleotide excision repair|Cell cycle CDK8 269.942808463735 261.693043640958 278.192573286512 1.06304917171658 0.0882083307833812 0.664465787777387 1 2.34719 2.23866 2.66237 2.30191 GeneID:1024,Genbank:NM_001260.2,HGNC:HGNC:1779,MIM:603184 cyclin dependent kinase 8 GO:0004672,GO:0004674,GO:0004693,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006367,GO:0007346,GO:0008353,GO:0016592,GO:0043234,GO:0045944 protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|nucleolus|transcription initiation from RNA polymerase II promoter|regulation of mitotic cell cycle|RNA polymerase II carboxy-terminal domain kinase activity|mediator complex|protein complex|positive regulation of transcription from RNA polymerase II promoter CDK9 888.005956339972 827.139027596944 948.872885083 1.14717460236367 0.198084989255682 0.206450344414046 1 13.8813 13.6557 16.0481 16.3871 GeneID:1025,Genbank:NM_001261.3,HGNC:HGNC:1780,MIM:603251 cyclin dependent kinase 9 hsa05202 Transcriptional misregulation in cancer CDKAL1 446.359515325811 453.634286071409 439.084744580214 0.967926715554953 -0.0470302737385161 0.801112846544451 1 2.69304 2.77279 2.70902 2.4695 GeneID:54901,Genbank:NM_017774.3,HGNC:HGNC:21050,MIM:611259 CDK5 regulatory subunit associated protein 1 like 1 GO:0005783,GO:0005789,GO:0005791,GO:0006400,GO:0016020,GO:0016021,GO:0035598,GO:0046872,GO:0051539,GO:0061712,GO:1990145 endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|tRNA modification|membrane|integral component of membrane|N6-threonylcarbomyladenosine methylthiotransferase activity|metal ion binding|4 iron, 4 sulfur cluster binding|tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase|maintenance of translational fidelity CDKL1 34.7533402771821 34.1314933476367 35.3751872067275 1.03643830776531 0.0516342450243905 0.964339839555127 1 0.119234 0.135805 0.119994 0.14393 GeneID:8814,Genbank:XM_017021731.2,HGNC:HGNC:1781,MIM:603441 cyclin dependent kinase like 1 CDKL2 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.00872647 0.00849914 0 0 GeneID:8999,Genbank:NM_003948.4,HGNC:HGNC:1782,MIM:603442 cyclin dependent kinase like 2 GO:0004693,GO:0005524,GO:0005634,GO:0005737,GO:0005813 cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|centrosome CDKL3 60.4611594336017 64.2267456200287 56.6955732471747 0.882740869085768 -0.1799381018057 0.671948929913165 1 0.192768 0.182805 0.203386 0.212879 GeneID:51265,Genbank:XM_024446092.1,HGNC:HGNC:15483,MIM:608459 cyclin dependent kinase like 3 GO:0004672,GO:0004693,GO:0005524,GO:0005634,GO:0005737,GO:0006464,GO:0030517,GO:0050775,GO:0097484 protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cellular protein modification process|negative regulation of axon extension|positive regulation of dendrite morphogenesis|dendrite extension CDKL4 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0.00692217 0 0 0 GeneID:344387,Genbank:XM_011532817.2,HGNC:HGNC:19287 cyclin dependent kinase like 4 GO:0004693,GO:0005524,GO:0005634,GO:0005737,GO:0006468 cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation CDKL5 66.9012748808581 70.7897789442142 63.0127708175021 0.890139392399561 -0.167896820631965 0.673100989642211 1 0.29837 0.225415 0.26251 0.188241 GeneID:6792,Genbank:NM_003159.2,HGNC:HGNC:11411,MIM:300203 cyclin dependent kinase like 5 GO:0001764,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006468,GO:0016301,GO:0032587,GO:0032839,GO:0043547,GO:0044294,GO:0045202,GO:0045773,GO:0046777,GO:0048365,GO:0048471,GO:0050773,GO:0050775,GO:0060999 neuron migration|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytosol|protein phosphorylation|kinase activity|ruffle membrane|dendrite cytoplasm|positive regulation of GTPase activity|dendritic growth cone|synapse|positive regulation of axon extension|protein autophosphorylation|Rac GTPase binding|perinuclear region of cytoplasm|regulation of dendrite development|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine development CDKN1A 2112.23323529828 2103.3782541347 2121.08821646187 1.00841977057258 0.0120963083422252 0.95199492034157 1 33.1442 35.9191 34.3624 37.4895 GeneID:1026,Genbank:NM_001220777.1,HGNC:HGNC:1784,MIM:116899 cyclin dependent kinase inhibitor 1A hsa01522,hsa01524,hsa04012,hsa04066,hsa04068,hsa04110,hsa04115,hsa04151,hsa04218,hsa04630,hsa04921,hsa04928,hsa04934,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05202,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05217,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Jak-STAT signaling pathway|Oxytocin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer CDKN1B 1410.03782544617 1458.22210244733 1361.85354844501 0.933913665249905 -0.0986389073430157 0.517358825558819 1 29.0728 26.1102 27.44 24.6031 GeneID:1027,Genbank:NM_004064.4,HGNC:HGNC:1785,MIM:600778 cyclin dependent kinase inhibitor 1B hsa01522,hsa04012,hsa04066,hsa04068,hsa04110,hsa04151,hsa04933,hsa04934,hsa05161,hsa05162,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05206,hsa05215,hsa05220,hsa05222,hsa05226 Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|PI3K-Akt signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Hepatitis B|Measles|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Prostate cancer|Chronic myeloid leukemia|Small cell lung cancer|Gastric cancer CDKN1C 33.2824872585279 37.014086829588 29.5508876874679 0.798368681186692 -0.324872967878114 0.603720679664055 1 1.37915 0.966702 0.694339 1.50428 GeneID:1028,Genbank:XM_005252732.4,HGNC:HGNC:1786,MIM:600856 cyclin dependent kinase inhibitor 1C GO:0004860,GO:0004861,GO:0005634,GO:0005737,GO:0007050,GO:0007346,GO:0030511,GO:0032403,GO:0033673,GO:0042326,GO:0045892,GO:0045893,GO:0050680,GO:1904030 protein kinase inhibitor activity|cyclin-dependent protein serine/threonine kinase inhibitor activity|nucleus|cytoplasm|cell cycle arrest|regulation of mitotic cell cycle|positive regulation of transforming growth factor beta receptor signaling pathway|protein complex binding|negative regulation of kinase activity|negative regulation of phosphorylation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of epithelial cell proliferation|negative regulation of cyclin-dependent protein kinase activity hsa04110 Cell cycle CDKN2A 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0105161 GeneID:1029,Genbank:XM_011517679.1,HGNC:HGNC:1787,MIM:600160 cyclin dependent kinase inhibitor 2A hsa01522,hsa01524,hsa04110,hsa04115,hsa04218,hsa04934,hsa05163,hsa05166,hsa05200,hsa05203,hsa05206,hsa05212,hsa05214,hsa05218,hsa05219,hsa05220,hsa05223,hsa05225 Endocrine resistance|Platinum drug resistance|Cell cycle|p53 signaling pathway|Cellular senescence|Cushing syndrome|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Pancreatic cancer|Glioma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Non-small cell lung cancer|Hepatocellular carcinoma CDKN2AIP 328.955830507274 352.556132755208 305.35552825934 0.866118895374198 -0.207363012206799 0.343363090903904 1 4.94672 4.42057 4.71859 3.3668 GeneID:55602,Genbank:NM_017632.3,HGNC:HGNC:24325,MIM:615914 CDKN2A interacting protein GO:0001652,GO:0002039,GO:0003723,GO:0005654,GO:0005730,GO:0006974,GO:0009967,GO:0030307,GO:0030308,GO:0031647 granular component|p53 binding|RNA binding|nucleoplasm|nucleolus|cellular response to DNA damage stimulus|positive regulation of signal transduction|positive regulation of cell growth|negative regulation of cell growth|regulation of protein stability CDKN2AIPNL 1258.75314600865 1278.85226268095 1238.65402933635 0.968566945129113 -0.0460763268353295 0.742838968871809 1 21.0922 22.9891 21.622 22.7244 GeneID:91368,Genbank:NM_080656.2,HGNC:HGNC:30545 CDKN2A interacting protein N-terminal like GO:0005654,GO:0005730,GO:0007165 nucleoplasm|nucleolus|signal transduction CDKN2D 665.700650493823 594.340579361255 737.060721626392 1.24013191631391 0.310493592297118 0.0876364091696206 0.970036792388817 22.484 24.509 28.0311 31.8114 GeneID:1032,Genbank:NM_079421.2,HGNC:HGNC:1790,MIM:600927 cyclin dependent kinase inhibitor 2D hsa04068,hsa04110 FoxO signaling pathway|Cell cycle CDKN3 964.494196338816 916.598529089368 1012.38986358826 1.10450740586946 0.143403092188279 0.343285768059575 1 14.8106 14.2688 16.0435 15.9557 GeneID:1033,Genbank:NM_001330173.1,HGNC:HGNC:1791,MIM:123832 cyclin dependent kinase inhibitor 3 CDNF 6.23103477869022 5.67894306964064 6.78312648773981 1.19443466936693 0.256327946504241 0.891235086997524 1 0.125752 0.119145 0.120452 0.139865 GeneID:441549,Genbank:XM_011519488.2,HGNC:HGNC:24913,MIM:611233 cerebral dopamine neurotrophic factor GO:0005615,GO:0005783,GO:0008083,GO:0031175,GO:0071542 extracellular space|endoplasmic reticulum|growth factor activity|neuron projection development|dopaminergic neuron differentiation CDO1 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0521322 0 0 GeneID:1036,Genbank:NM_001323566.1,HGNC:HGNC:1795,MIM:603943 cysteine dioxygenase type 1 GO:0005506,GO:0005829,GO:0017172,GO:0042412 iron ion binding|cytosol|cysteine dioxygenase activity|taurine biosynthetic process hsa00270,hsa00430 Cysteine and methionine metabolism|Taurine and hypotaurine metabolism CDON 861.536996262275 880.766498817542 842.307493707007 0.956334618582601 -0.0644125937283832 0.691223032845407 1 3.77944 3.57849 3.74655 3.39057 GeneID:50937,Genbank:XM_017017873.1,HGNC:HGNC:17104,MIM:608707 cell adhesion associated, oncogene regulated GO:0001708,GO:0002088,GO:0005886,GO:0005887,GO:0007155,GO:0007224,GO:0007520,GO:0009952,GO:0010172,GO:0014816,GO:0021987,GO:0043410,GO:0043497,GO:0045663,GO:0045666,GO:0045944,GO:0048643,GO:0051057,GO:0051149,GO:0060059,GO:2000179 cell fate specification|lens development in camera-type eye|plasma membrane|integral component of plasma membrane|cell adhesion|smoothened signaling pathway|myoblast fusion|anterior/posterior pattern specification|embryonic body morphogenesis|skeletal muscle satellite cell differentiation|cerebral cortex development|positive regulation of MAPK cascade|regulation of protein heterodimerization activity|positive regulation of myoblast differentiation|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of skeletal muscle tissue development|positive regulation of small GTPase mediated signal transduction|positive regulation of muscle cell differentiation|embryonic retina morphogenesis in camera-type eye|positive regulation of neural precursor cell proliferation hsa04340 Hedgehog signaling pathway CDPF1 140.945710901726 146.201922915 135.689498888451 0.928096540613486 -0.107653212573108 0.688911743418278 1 2.29914 2.34743 2.37787 2.00778 GeneID:150383,Genbank:XM_011529960.2,HGNC:HGNC:33710 cysteine rich DPF motif domain containing 1 CDR1 1.02523254288787 1.56626675524197 0.484198330533773 0.309141676482158 -1.69365993276169 0.789571303159055 1 0.0223829 0.0218946 0 0.0200873 GeneID:1038,Genbank:NM_004065.2,HGNC:HGNC:1798,MIM:302650 cerebellar degeneration related protein 1 CDR2 563.642874160469 582.539631093846 544.746117227091 0.935122845125937 -0.0967721936171007 0.580126007726331 1 7.65577 7.30135 7.57588 6.62521 GeneID:1039,Genbank:NM_001802.1,HGNC:HGNC:1799,MIM:117340 cerebellar degeneration related protein 2 GO:0005737 cytoplasm CDR2L 1319.6865452545 1186.35628022742 1453.01681028158 1.22477272173503 0.292514056454713 0.0635080377575916 0.897898872552551 15.4491 17.1893 22.2981 18.2514 GeneID:30850,Genbank:NM_014603.2,HGNC:HGNC:29999 cerebellar degeneration related protein 2 like CDRT1 9.78309946928072 8.4174577275371 11.1487412110243 1.32447843183721 0.40542435066499 0.673376821988562 1 0.0611783 0.0162576 0.0582374 0.0619255 GeneID:374286,Genbank:NM_001282540.1,HGNC:HGNC:14379,MIM:604596 CMT1A duplicated region transcript 1 GO:0000209,GO:0004842,GO:0005829,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|post-translational protein modification CDS1 130.999666343942 146.163705295423 115.83562739246 0.792506095534012 -0.335506063152199 0.202573742067095 1 1.36427 1.65886 1.33247 1.07063 GeneID:1040,Genbank:NM_001263.3,HGNC:HGNC:1800,MIM:603548 CDP-diacylglycerol synthase 1 GO:0004142,GO:0004605,GO:0005783,GO:0005789,GO:0006655,GO:0006661,GO:0007165,GO:0007602,GO:0016021,GO:0016024 diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|phosphatidylglycerol biosynthetic process|phosphatidylinositol biosynthetic process|signal transduction|phototransduction|integral component of membrane|CDP-diacylglycerol biosynthetic process hsa00564,hsa04070 Glycerophospholipid metabolism|Phosphatidylinositol signaling system CDS2 1209.32611468444 1078.66503331064 1339.98719605824 1.24226442378089 0.312972292941643 0.0340959538159663 0.729079834868512 4.15211 3.97275 5.14969 5.16129 GeneID:8760,Genbank:NM_003818.3,HGNC:HGNC:1801,MIM:603549 CDP-diacylglycerol synthase 2 GO:0004605,GO:0005743,GO:0005789,GO:0006655,GO:0016020,GO:0016021,GO:0016024 phosphatidate cytidylyltransferase activity|mitochondrial inner membrane|endoplasmic reticulum membrane|phosphatidylglycerol biosynthetic process|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process hsa00564,hsa04070 Glycerophospholipid metabolism|Phosphatidylinositol signaling system CDSN 1.70393875003029 1.47021420587209 1.93766329418849 1.31794624650571 0.398291530071997 1 1 0 0.0349681 0.0183655 0.0517596 GeneID:1041,Genbank:NM_001264.4,HGNC:HGNC:1802,MIM:602593 corneodesmosin GO:0005576,GO:0042803,GO:0043589 extracellular region|protein homodimerization activity|skin morphogenesis CDT1 1291.27353887014 1312.81126824007 1269.73580950022 0.967188384361149 -0.0481311765257138 0.723176229120325 1 21.6426 22.9777 22.567 21.4518 GeneID:81620,Genbank:NM_030928.3,HGNC:HGNC:24576,MIM:605525 chromatin licensing and DNA replication factor 1 CDV3 2952.11438284276 3041.34273480717 2862.88603087834 0.941323053831963 -0.087238166644596 0.542109941470242 1 27.2024 25.2679 27.4898 22.6534 GeneID:55573,Genbank:NM_001134422.1,HGNC:HGNC:26928 CDV3 homolog GO:0005829,GO:0005886,GO:0008283 cytosol|plasma membrane|cell proliferation CDX1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0274119 0 0 0 GeneID:1044,Genbank:NM_001804.2,HGNC:HGNC:1805,MIM:600746 caudal type homeobox 1 GO:0000980,GO:0001205,GO:0005634,GO:0009887,GO:0009948,GO:0014807,GO:0030154,GO:0044212,GO:0045944,GO:0060349 RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|nucleus|animal organ morphogenesis|anterior/posterior axis specification|regulation of somitogenesis|cell differentiation|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|bone morphogenesis CDYL 1139.70051726116 1110.00998572569 1169.39104879663 1.05349597195931 0.0751847980228653 0.611348808148087 1 10.9885 10.669 11.5369 11.5139 GeneID:9425,Genbank:NM_004824.3,HGNC:HGNC:1811,MIM:603778 chromodomain Y like GO:0003682,GO:0003714,GO:0005634,GO:0005694,GO:0006351,GO:0006355,GO:0007283,GO:0007286,GO:0016607,GO:0030674,GO:0035064,GO:0060816,GO:0120092,GO:0120094 chromatin binding|transcription corepressor activity|nucleus|chromosome|transcription, DNA-templated|regulation of transcription, DNA-templated|spermatogenesis|spermatid development|nuclear speck|protein binding, bridging|methylated histone binding|random inactivation of X chromosome|crotonyl-CoA hydratase activity|negative regulation of peptidyl-lysine crotonylation CDYL2 346.589723759622 337.393345259853 355.786102259391 1.05451428505613 0.0765786388395693 0.804747060283649 1 1.49917 1.49133 1.98086 1.19357 GeneID:124359,Genbank:XM_011522866.1,HGNC:HGNC:23030 chromodomain Y like 2 GO:0003824,GO:0005634,GO:0008152,GO:0035064 catalytic activity|nucleus|metabolic process|methylated histone binding CEACAM1 1.4602080071317 0.980142803914724 1.94027321034868 1.97958216149643 0.985195946894947 0.869450732833891 1 0 0.00919928 0.0282531 0 GeneID:634,Genbank:NM_001184816.1,HGNC:HGNC:1814,MIM:109770 carcinoembryonic antigen related cell adhesion molecule 1 CEACAM16 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0300077 0 GeneID:388551,Genbank:NM_001039213.3,HGNC:HGNC:31948,MIM:614591 carcinoembryonic antigen related cell adhesion molecule 16 GO:0005615,GO:0007605,GO:0032426,GO:0042802 extracellular space|sensory perception of sound|stereocilium tip|identical protein binding CEACAM19 39.2810751186241 32.5172003177098 46.0449499195385 1.41601827554819 0.501839885387435 0.288804655688944 1 0.292953 0.422598 0.529406 0.40653 GeneID:56971,Genbank:NM_020219.3,HGNC:HGNC:31951,MIM:606691 carcinoembryonic antigen related cell adhesion molecule 19 GO:0016021 integral component of membrane CEACAM20 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00635526 0 0 GeneID:125931,Genbank:XM_024451345.1,HGNC:HGNC:24879 carcinoembryonic antigen related cell adhesion molecule 20 GO:0002376,GO:0016021,GO:0016324,GO:0031528 immune system process|integral component of membrane|apical plasma membrane|microvillus membrane CEBPA 108.577890272787 123.149966713643 94.0058138319305 0.763344208208511 -0.389594349101907 0.170862399123668 1 2.6621 2.85638 1.9069 2.39133 GeneID:1050,Genbank:NM_004364.4,HGNC:HGNC:1833,MIM:116897 CCAAT enhancer binding protein alpha hsa04932,hsa05200,hsa05202,hsa05221 Non-alcoholic fatty liver disease (NAFLD)|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia CEBPB 1289.56606895948 1316.29081132931 1262.84132658965 0.959393863210453 -0.0598048835574279 0.753608185636198 1 46.3143 51.4877 44.7513 51.2383 GeneID:1051,Genbank:NM_005194.3,HGNC:HGNC:1834,MIM:189965 CCAAT enhancer binding protein beta hsa04657,hsa04668,hsa05152,hsa05202 IL-17 signaling pathway|TNF signaling pathway|Tuberculosis|Transcriptional misregulation in cancer CEBPD 460.926287961434 341.737361293424 580.115214629445 1.69754694784848 0.76345147461232 2.25189951344967e-05 0.00847369839142897 20.8687 21.685 38.8674 35.2311 GeneID:1052,Genbank:NM_005195.3,HGNC:HGNC:1835,MIM:116898 CCAAT enhancer binding protein delta GO:0000978,GO:0001077,GO:0005654,GO:0006366,GO:0019221 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleoplasm|transcription from RNA polymerase II promoter|cytokine-mediated signaling pathway CEBPG 1164.96835535315 1248.21687873021 1081.71983197609 0.866612085134202 -0.206541739374266 0.171007404624348 1 12.5942 12.1146 11.3897 10.1073 GeneID:1054,Genbank:NM_001806.3,HGNC:HGNC:1837,MIM:138972 CCAAT enhancer binding protein gamma GO:0000978,GO:0001077,GO:0001889,GO:0003677,GO:0005634,GO:0005654,GO:0006357,GO:0006955,GO:0008134,GO:0016071,GO:0030183,GO:0042267,GO:0042803,GO:0043353,GO:0043388,GO:0043433,GO:0043565,GO:0045078,GO:0045739,GO:0045944,GO:0046982,GO:0051091 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|liver development|DNA binding|nucleus|nucleoplasm|regulation of transcription from RNA polymerase II promoter|immune response|transcription factor binding|mRNA metabolic process|B cell differentiation|natural killer cell mediated cytotoxicity|protein homodimerization activity|enucleate erythrocyte differentiation|positive regulation of DNA binding|negative regulation of DNA binding transcription factor activity|sequence-specific DNA binding|positive regulation of interferon-gamma biosynthetic process|positive regulation of DNA repair|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|positive regulation of DNA binding transcription factor activity hsa05152 Tuberculosis CEBPZ 297.382784343864 339.824084959424 254.941483728303 0.750216052987367 -0.414621961030232 0.0412123987137538 0.759435523043776 3.07992 2.90058 2.6367 1.86274 GeneID:10153,Genbank:NM_005760.2,HGNC:HGNC:24218,MIM:612828 CCAAT enhancer binding protein zeta GO:0000978,GO:0001077,GO:0003677,GO:0003723,GO:0005634,GO:0006366,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|RNA binding|nucleus|transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter CEBPZOS 616.879594460711 630.383315041181 603.375873880241 0.957157112955669 -0.0631723389557009 0.713014673448689 1 7.10477 6.90187 7.1862 6.32833 GeneID:100505876,Genbank:NM_001322373.1,HGNC:HGNC:49288 CEBPZ opposite strand GO:0016021,GO:0031966 integral component of membrane|mitochondrial membrane CECR2 13.4962200738788 13.904295698438 13.0881444493196 0.941302222937474 -0.0872700929429925 0.968941743718566 1 0.043958 0.0347718 0.0476583 0.0278101 GeneID:27443,Genbank:NM_001290046.1,HGNC:HGNC:1840,MIM:607576 CECR2, histone acetyl-lysine reader GO:0000910,GO:0005634,GO:0006309,GO:0007010,GO:0016192,GO:0016569,GO:0021915,GO:0043044,GO:0090537,GO:0097194 cytokinesis|nucleus|apoptotic DNA fragmentation|cytoskeleton organization|vesicle-mediated transport|covalent chromatin modification|neural tube development|ATP-dependent chromatin remodeling|CERF complex|execution phase of apoptosis CEL 3.26433243384867 3.6226049124413 2.90605995525603 0.802201737560615 -0.317963003869112 0.956947929395741 1 0.0507017 0.0288538 0.0155329 0.029076 GeneID:1056,Genbank:NM_001807.4,HGNC:HGNC:1848,MIM:114840 carboxyl ester lipase GO:0003824,GO:0004771,GO:0004806,GO:0005576,GO:0005615,GO:0005737,GO:0006629,GO:0006707,GO:0008201,GO:0009062,GO:0016787,GO:0018350,GO:0030157,GO:0030299,GO:0044241,GO:0044258,GO:0047372,GO:0052689,GO:0070062 catalytic activity|sterol esterase activity|triglyceride lipase activity|extracellular region|extracellular space|cytoplasm|lipid metabolic process|cholesterol catabolic process|heparin binding|fatty acid catabolic process|hydrolase activity|protein esterification|pancreatic juice secretion|intestinal cholesterol absorption|lipid digestion|intestinal lipid catabolic process|acylglycerol lipase activity|carboxylic ester hydrolase activity|extracellular exosome hsa00100,hsa00561,hsa04972,hsa04975 Steroid biosynthesis|Glycerolipid metabolism|Pancreatic secretion|Fat digestion and absorption CELA1 1.75533654645372 2.05633815719933 1.45433493570811 0.707245027096551 -0.499717967356846 0.969172040919743 1 0 0.0516 0.108593 0.0502127 GeneID:1990,Genbank:NM_001971.5,HGNC:HGNC:3308,MIM:130120 chymotrypsin like elastase family member 1 CELA2B 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:51032,Genbank:NM_015849.2,HGNC:HGNC:29995,MIM:609444 chymotrypsin like elastase family member 2B GO:0004252,GO:0005576,GO:0005615 serine-type endopeptidase activity|extracellular region|extracellular space hsa04972,hsa04974 Pancreatic secretion|Protein digestion and absorption CELF1 2686.73222162685 2826.54367527582 2546.92076797788 0.901072497218479 -0.150284909858613 0.279095080985753 1 12.5535 11.9281 12.5775 9.9838 GeneID:10658,Genbank:NM_001330272.1,HGNC:HGNC:2549,MIM:601074 CUGBP Elav-like family member 1 GO:0003723,GO:0005634,GO:0005737,GO:0006397,GO:0008380,GO:0043484 RNA binding|nucleus|cytoplasm|mRNA processing|RNA splicing|regulation of RNA splicing CELF2 178.166302100922 171.166138449502 185.166465752343 1.08179379069752 0.113425521816834 0.740123492327296 1 0.602455 0.585333 0.840194 0.481796 GeneID:10659,Genbank:NM_001326323.1,HGNC:HGNC:2550,MIM:602538 CUGBP Elav-like family member 2 GO:0003723,GO:0005634,GO:0005737,GO:0006376,GO:0006396,GO:0008016,GO:0036002 RNA binding|nucleus|cytoplasm|mRNA splice site selection|RNA processing|regulation of heart contraction|pre-mRNA binding CELF3 16.8206515448112 20.073310170036 13.5679929195864 0.675922047965948 -0.565071220417769 0.436199347829532 1 0.0799893 0.0766432 0.0501708 0.0625587 GeneID:11189,Genbank:XM_006711141.3,HGNC:HGNC:11967,MIM:612678 CUGBP Elav-like family member 3 GO:0000381,GO:0003723,GO:0005634,GO:0005737,GO:0006397,GO:0007283,GO:0008380,GO:0016604,GO:0030317,GO:0030575,GO:0036002,GO:0048026,GO:0097322,GO:0098781 regulation of alternative mRNA splicing, via spliceosome|RNA binding|nucleus|cytoplasm|mRNA processing|spermatogenesis|RNA splicing|nuclear body|flagellated sperm motility|nuclear body organization|pre-mRNA binding|positive regulation of mRNA splicing, via spliceosome|7SK snRNA binding|ncRNA transcription CELF5 6.97832301050014 9.10944288334217 4.84720313765811 0.532107528389235 -0.910210279614975 0.428694796053258 1 0.0449201 0.0721431 0.0277859 0.0260241 GeneID:60680,Genbank:XM_006722832.1,HGNC:HGNC:14058,MIM:612680 CUGBP Elav-like family member 5 GO:0000381,GO:0005634,GO:0005737,GO:0006397,GO:0036002 regulation of alternative mRNA splicing, via spliceosome|nucleus|cytoplasm|mRNA processing|pre-mRNA binding CELF6 1.02229600717608 1.07619535328461 0.968396661067546 0.899833527539349 -0.152269972565186 1 1 0.0278212 0 0 0.0241921 GeneID:60677,Genbank:NM_052840.4,HGNC:HGNC:14059,MIM:612681 CUGBP Elav-like family member 6 GO:0000381,GO:0003723,GO:0005634,GO:0005737,GO:0005829,GO:0006397 regulation of alternative mRNA splicing, via spliceosome|RNA binding|nucleus|cytoplasm|cytosol|mRNA processing CELSR1 11.5083555748719 13.8082431490681 9.20846800067565 0.666881941552219 -0.584496711906862 0.511430103803632 1 0.0430155 0.0471461 0.0325795 0.0236591 GeneID:9620,Genbank:NM_014246.1,HGNC:HGNC:1850,MIM:604523 cadherin EGF LAG seven-pass G-type receptor 1 GO:0001736,GO:0001764,GO:0001843,GO:0001942,GO:0004888,GO:0004930,GO:0005509,GO:0005654,GO:0005886,GO:0005887,GO:0007156,GO:0007186,GO:0007266,GO:0007417,GO:0007626,GO:0009952,GO:0016021,GO:0032956,GO:0042060,GO:0042249,GO:0042472,GO:0045176,GO:0046983,GO:0048105,GO:0060071,GO:0060488,GO:0060489,GO:0060490,GO:0090179,GO:0090251 establishment of planar polarity|neuron migration|neural tube closure|hair follicle development|transmembrane signaling receptor activity|G-protein coupled receptor activity|calcium ion binding|nucleoplasm|plasma membrane|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|G-protein coupled receptor signaling pathway|Rho protein signal transduction|central nervous system development|locomotory behavior|anterior/posterior pattern specification|integral component of membrane|regulation of actin cytoskeleton organization|wound healing|establishment of planar polarity of embryonic epithelium|inner ear morphogenesis|apical protein localization|protein dimerization activity|establishment of body hair planar orientation|Wnt signaling pathway, planar cell polarity pathway|orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis|planar dichotomous subdivision of terminal units involved in lung branching morphogenesis|lateral sprouting involved in lung morphogenesis|planar cell polarity pathway involved in neural tube closure|protein localization involved in establishment of planar polarity CELSR2 2174.85824486364 2061.83785482791 2287.87863489937 1.10963072558891 0.150079641441264 0.291403427695465 1 7.7822 8.01851 8.91791 9.0234 GeneID:1952,Genbank:NM_001408.2,HGNC:HGNC:3231,MIM:604265 cadherin EGF LAG seven-pass G-type receptor 2 GO:0004930,GO:0005509,GO:0005737,GO:0005886,GO:0006355,GO:0007156,GO:0007186,GO:0016021,GO:0016055,GO:0021999,GO:0022407,GO:0048813,GO:0060071 G-protein coupled receptor activity|calcium ion binding|cytoplasm|plasma membrane|regulation of transcription, DNA-templated|homophilic cell adhesion via plasma membrane adhesion molecules|G-protein coupled receptor signaling pathway|integral component of membrane|Wnt signaling pathway|neural plate anterior/posterior regionalization|regulation of cell-cell adhesion|dendrite morphogenesis|Wnt signaling pathway, planar cell polarity pathway CELSR3 364.700259135772 373.206775222318 356.193743049226 0.954413924658904 -0.0673130031432 0.71610060840661 1 1.2317 1.30468 1.20618 1.23345 GeneID:1951,Genbank:NM_001407.2,HGNC:HGNC:3230,MIM:604264 cadherin EGF LAG seven-pass G-type receptor 3 GO:0001764,GO:0001932,GO:0004930,GO:0005509,GO:0005886,GO:0007156,GO:0007186,GO:0007413,GO:0016021,GO:0032880,GO:0036514,GO:0036515,GO:0060071,GO:0060271,GO:1904938 neuron migration|regulation of protein phosphorylation|G-protein coupled receptor activity|calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|G-protein coupled receptor signaling pathway|axonal fasciculation|integral component of membrane|regulation of protein localization|dopaminergic neuron axon guidance|serotonergic neuron axon guidance|Wnt signaling pathway, planar cell polarity pathway|cilium assembly|planar cell polarity pathway involved in axon guidance CEMIP 112.050230201596 106.353268878146 117.747191525047 1.10713279212842 0.146828272756765 0.632425509383785 1 0.412746 0.505836 0.43886 0.586863 GeneID:57214,Genbank:NM_001293298.1,HGNC:HGNC:29213,MIM:608366 cell migration inducing hyaluronidase 1 GO:0004415,GO:0005540,GO:0005576,GO:0005634,GO:0005737,GO:0005783,GO:0005886,GO:0005905,GO:0007605,GO:0010800,GO:0030213,GO:0030214,GO:0030335,GO:0030665,GO:0032050,GO:0045334,GO:0046923,GO:0051281,GO:0090314,GO:1900020 hyalurononglucosaminidase activity|hyaluronic acid binding|extracellular region|nucleus|cytoplasm|endoplasmic reticulum|plasma membrane|clathrin-coated pit|sensory perception of sound|positive regulation of peptidyl-threonine phosphorylation|hyaluronan biosynthetic process|hyaluronan catabolic process|positive regulation of cell migration|clathrin-coated vesicle membrane|clathrin heavy chain binding|clathrin-coated endocytic vesicle|ER retention sequence binding|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of protein targeting to membrane|positive regulation of protein kinase C activity CEMIP2 1924.17150644567 1830.72708385873 2017.61592903261 1.10208449245201 0.140234833862538 0.309667865503938 1 10.1978 9.50793 11.9897 10.0893 GeneID:23670,Genbank:NM_001135820.1,HGNC:HGNC:11869,MIM:605835 cell migration inducing hyaluronidase 2 GO:0001525,GO:0004415,GO:0005509,GO:0005887,GO:0016021,GO:0030214,GO:0045296,GO:0070062,GO:1903670 angiogenesis|hyalurononglucosaminidase activity|calcium ion binding|integral component of plasma membrane|integral component of membrane|hyaluronan catabolic process|cadherin binding|extracellular exosome|regulation of sprouting angiogenesis CEMP1 10.9964234648518 9.39760053145183 12.5952463982519 1.34026194836631 0.422514996709947 0.675757330059294 1 0.342317 0.179887 0.126611 0.415331 GeneID:752014,Genbank:NM_001048212.3,HGNC:HGNC:32553,MIM:611113 cementum protein 1 GO:0005634,GO:0005737,GO:0008283,GO:0030154,GO:0031214,GO:0042476,GO:0046848 nucleus|cytoplasm|cell proliferation|cell differentiation|biomineral tissue development|odontogenesis|hydroxyapatite binding CEND1 708.337564292435 534.552885323311 882.122243261558 1.65020574667374 0.722645910047358 0.000941530095944935 0.099246113460475 12.5966 12.8523 24.5466 18.5169 GeneID:51286,Genbank:NM_016564.3,HGNC:HGNC:24153,MIM:608213 cell cycle exit and neuronal differentiation 1 GO:0007628,GO:0016021,GO:0021686,GO:0021702,GO:0021933,GO:0021941 adult walking behavior|integral component of membrane|cerebellar granular layer maturation|cerebellar Purkinje cell differentiation|radial glia guided migration of cerebellar granule cell|negative regulation of cerebellar granule cell precursor proliferation CENPA 884.162886982666 846.135125412841 922.190648552492 1.08988578875335 0.124176960110242 0.414522128037928 1 30.2017 27.8393 30.8581 33.8788 GeneID:1058,Genbank:NM_001809.3,HGNC:HGNC:1851,MIM:117139 centromere protein A GO:0000132,GO:0000281,GO:0000775,GO:0000778,GO:0000780,GO:0000788,GO:0000939,GO:0003682,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0007062,GO:0016032,GO:0031492,GO:0031618,GO:0034080,GO:0046982,GO:0051382,GO:0071459 establishment of mitotic spindle orientation|mitotic cytokinesis|chromosome, centromeric region|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region|nuclear nucleosome|condensed chromosome inner kinetochore|chromatin binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|sister chromatid cohesion|viral process|nucleosomal DNA binding|nuclear pericentric heterochromatin|CENP-A containing nucleosome assembly|protein heterodimerization activity|kinetochore assembly|protein localization to chromosome, centromeric region CENPB 3793.98750542801 3812.84328965188 3775.13172120414 0.990109331650191 -0.0143402530077157 0.889435587914214 1 53.6785 58.3664 55.7645 57.2885 GeneID:1059,Genbank:NM_001810.5,HGNC:HGNC:1852,MIM:117140 centromere protein B GO:0000775,GO:0000780,GO:0003682,GO:0003696,GO:0005694,GO:0016604,GO:0019237,GO:0031618,GO:0043565 chromosome, centromeric region|condensed nuclear chromosome, centromeric region|chromatin binding|satellite DNA binding|chromosome|nuclear body|centromeric DNA binding|nuclear pericentric heterochromatin|sequence-specific DNA binding CENPBD1 260.737930863077 236.036842950651 285.439018775504 1.2092985790154 0.274170493786999 0.184302336228971 1 3.48527 3.03688 3.96617 4.03992 GeneID:92806,Genbank:NM_145039.3,HGNC:HGNC:28272 CENPB DNA-binding domain containing 1 GO:0003677,GO:0005634 DNA binding|nucleus CENPC 99.7294725184721 112.214508391418 87.2444366455256 0.777479114743398 -0.363124173934573 0.231936635731942 1 0.563444 0.513914 0.454915 0.338604 GeneID:1060,Genbank:XM_006714064.3,HGNC:HGNC:1854,MIM:117141 centromere protein C GO:0000278,GO:0000776,GO:0000778,GO:0000780,GO:0003677,GO:0005654,GO:0005721,GO:0005829,GO:0007059,GO:0007062,GO:0016604,GO:0019237,GO:0030496,GO:0031618,GO:0032154,GO:0034080,GO:0045171,GO:0051301,GO:0051315,GO:0051382,GO:0051455,GO:0090543 mitotic cell cycle|kinetochore|condensed nuclear chromosome kinetochore|condensed nuclear chromosome, centromeric region|DNA binding|nucleoplasm|pericentric heterochromatin|cytosol|chromosome segregation|sister chromatid cohesion|nuclear body|centromeric DNA binding|midbody|nuclear pericentric heterochromatin|cleavage furrow|CENP-A containing nucleosome assembly|intercellular bridge|cell division|attachment of mitotic spindle microtubules to kinetochore|kinetochore assembly|attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation|Flemming body CENPE 70.6008853775222 68.9735721604396 72.2281985946049 1.04718657207712 0.0665185030432827 0.891482462540911 1 0.202555 0.135554 0.20989 0.119553 GeneID:1062,Genbank:NM_001286734.1,HGNC:HGNC:1856,MIM:117143 centromere protein E GO:0000278,GO:0000775,GO:0000776,GO:0000777,GO:0000779,GO:0003777,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005828,GO:0005829,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0007052,GO:0007059,GO:0007062,GO:0007079,GO:0007080,GO:0007275,GO:0008017,GO:0015630,GO:0016020,GO:0016887,GO:0019886,GO:0030071,GO:0030496,GO:0043515,GO:0045860,GO:0051301,GO:0051310,GO:0051315,GO:0051382,GO:0099606,GO:0099607,GO:1990023 mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed chromosome, centromeric region|microtubule motor activity|ATP binding|nucleus|nucleoplasm|chromosome|kinetochore microtubule|cytosol|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|mitotic spindle organization|chromosome segregation|sister chromatid cohesion|mitotic chromosome movement towards spindle pole|mitotic metaphase plate congression|multicellular organism development|microtubule binding|microtubule cytoskeleton|membrane|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|regulation of mitotic metaphase/anaphase transition|midbody|kinetochore binding|positive regulation of protein kinase activity|cell division|metaphase plate congression|attachment of mitotic spindle microtubules to kinetochore|kinetochore assembly|microtubule plus-end directed mitotic chromosome migration|lateral attachment of mitotic spindle microtubules to kinetochore|mitotic spindle midzone CENPF 618.297670165799 557.900773826177 678.694566505422 1.21651483264815 0.282753910788028 0.617002180289065 1 1.61371 1.28274 2.43517 1.09436 GeneID:1063,Genbank:NM_016343.3,HGNC:HGNC:1857,MIM:600236 centromere protein F CENPH 1064.10656310206 1061.53215155234 1066.68097465178 1.00485036943244 0.00698068812111796 0.957591713191265 1 32.5009 32.9673 34.1892 31.0542 GeneID:64946,Genbank:NM_022909.3,HGNC:HGNC:17268,MIM:605607 centromere protein H GO:0000776,GO:0000777,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0007062,GO:0034080,GO:0043515,GO:0051382,GO:0051383 kinetochore|condensed chromosome kinetochore|nucleus|nucleoplasm|nucleolus|cytosol|sister chromatid cohesion|CENP-A containing nucleosome assembly|kinetochore binding|kinetochore assembly|kinetochore organization CENPI 912.227864160107 849.296067887793 975.159660432421 1.14819754535971 0.199370876502038 0.230559906888107 1 4.5958 4.22133 5.83891 4.51531 GeneID:2491,Genbank:XM_011530897.2,HGNC:HGNC:3968,MIM:300065 centromere protein I GO:0000776,GO:0005654,GO:0005829,GO:0007062,GO:0007548,GO:0016604,GO:0034080 kinetochore|nucleoplasm|cytosol|sister chromatid cohesion|sex differentiation|nuclear body|CENP-A containing nucleosome assembly CENPJ 221.045454766069 227.359636539473 214.731272992665 0.944456440294249 -0.0824438359345554 0.825202035964943 1 0.787591 0.635028 0.852867 0.554428 GeneID:55835,Genbank:NM_018451.4,HGNC:HGNC:17272,MIM:609279 centromere protein J GO:0000086,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0005886,GO:0006977,GO:0007020,GO:0007099,GO:0008275,GO:0010389,GO:0015631,GO:0019901,GO:0019904,GO:0042802,GO:0046599,GO:0046785,GO:0051301,GO:0061511,GO:0097711 G2/M transition of mitotic cell cycle|nucleoplasm|centrosome|centriole|cytosol|microtubule|plasma membrane|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|microtubule nucleation|centriole replication|gamma-tubulin small complex|regulation of G2/M transition of mitotic cell cycle|tubulin binding|protein kinase binding|protein domain specific binding|identical protein binding|regulation of centriole replication|microtubule polymerization|cell division|centriole elongation|ciliary basal body-plasma membrane docking CENPK 469.578282822749 507.799854968649 431.356710676849 0.849462059620871 -0.235378582579896 0.195341425294605 1 2.22475 2.00523 2.05222 1.63111 GeneID:64105,Genbank:XM_017009693.1,HGNC:HGNC:29479,MIM:611502 centromere protein K GO:0000777,GO:0005654,GO:0005829,GO:0007062,GO:0034080 condensed chromosome kinetochore|nucleoplasm|cytosol|sister chromatid cohesion|CENP-A containing nucleosome assembly CENPL 572.110305530343 552.454187476562 591.766423584124 1.07115926894704 0.0991730080402343 0.566694251263671 1 7.02962 7.43479 8.89378 7.30324 GeneID:91687,Genbank:NM_033319.3,HGNC:HGNC:17879,MIM:611503 centromere protein L GO:0000775,GO:0005654,GO:0005829,GO:0007062,GO:0034080 chromosome, centromeric region|nucleoplasm|cytosol|sister chromatid cohesion|CENP-A containing nucleosome assembly CENPM 855.258475062783 780.093190009892 930.423760115673 1.19270847641148 0.254241460442514 0.107379052805753 1 4.11452 4.22619 4.12846 5.53537 GeneID:79019,Genbank:XM_011530368.2,HGNC:HGNC:18352,MIM:610152 centromere protein M GO:0000777,GO:0005654,GO:0005829,GO:0007062,GO:0034080 condensed chromosome kinetochore|nucleoplasm|cytosol|sister chromatid cohesion|CENP-A containing nucleosome assembly CENPN 1890.28682566404 1988.46141470325 1792.11223662483 0.901255726348747 -0.149991573988889 0.289486522706199 1 11.995 11.9717 10.4409 10.8004 GeneID:55839,Genbank:NM_001100625.2,HGNC:HGNC:30873,MIM:611509 centromere protein N GO:0000777,GO:0005634,GO:0005654,GO:0005829,GO:0007062,GO:0034080 condensed chromosome kinetochore|nucleus|nucleoplasm|cytosol|sister chromatid cohesion|CENP-A containing nucleosome assembly CENPO 1821.05546115707 1828.64437073877 1813.46655157536 0.991699961235611 -0.0120243955578831 0.924972581709628 1 14.3575 15.1199 15.6577 14.8108 GeneID:79172,Genbank:NM_024322.3,HGNC:HGNC:28152,MIM:611504 centromere protein O GO:0000777,GO:0005654,GO:0005829,GO:0007062,GO:0034080 condensed chromosome kinetochore|nucleoplasm|cytosol|sister chromatid cohesion|CENP-A containing nucleosome assembly CENPP 161.879136012626 173.510634254811 150.24763777044 0.865927546260896 -0.207681777814148 0.41582679686848 1 0.951504 0.79407 0.865603 0.739528 GeneID:401541,Genbank:XM_011518689.1,HGNC:HGNC:32933,MIM:611505 centromere protein P GO:0000775,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0007062,GO:0034080 chromosome, centromeric region|nucleus|nucleoplasm|nucleolus|cytosol|sister chromatid cohesion|CENP-A containing nucleosome assembly CENPQ 283.679618292841 308.54677612927 258.812460456413 0.838811099254462 -0.253582143403468 0.220068907773726 1 5.76804 5.48453 5.01649 4.29956 GeneID:55166,Genbank:XM_011514723.2,HGNC:HGNC:21347,MIM:611506 centromere protein Q GO:0000775,GO:0005654,GO:0005829,GO:0007062,GO:0015629,GO:0034080,GO:0051310,GO:1905342 chromosome, centromeric region|nucleoplasm|cytosol|sister chromatid cohesion|actin cytoskeleton|CENP-A containing nucleosome assembly|metaphase plate congression|positive regulation of protein localization to kinetochore CENPS 24.2082698975325 19.8331787966113 28.5833609984537 1.44118909487861 0.527259640402127 0.495221621573322 1 9.60451 8.24405 7.71573 8.55465 GeneID:378708,Genbank:NM_199294.2,HGNC:HGNC:23163,MIM:609130 centromere protein S GO:0000712,GO:0000777,GO:0003677,GO:0003682,GO:0005654,GO:0005829,GO:0006281,GO:0006312,GO:0006974,GO:0007062,GO:0031297,GO:0031398,GO:0034080,GO:0036297,GO:0043240,GO:0046982,GO:0051301,GO:0051382,GO:0071821 resolution of meiotic recombination intermediates|condensed chromosome kinetochore|DNA binding|chromatin binding|nucleoplasm|cytosol|DNA repair|mitotic recombination|cellular response to DNA damage stimulus|sister chromatid cohesion|replication fork processing|positive regulation of protein ubiquitination|CENP-A containing nucleosome assembly|interstrand cross-link repair|Fanconi anaemia nuclear complex|protein heterodimerization activity|cell division|kinetochore assembly|FANCM-MHF complex hsa03460 Fanconi anemia pathway CENPS-CORT 93.9852087880177 93.9672136602651 94.0032039157703 1.00038300864848 0.000552458886263363 1 1 3.26712 4.11754 3.07293 4.27962 GeneID:100526739,Genbank:NM_001270517.1,HGNC:HGNC:38843 CENPS-CORT readthrough GO:0001664,GO:0005184,GO:0005576,GO:0005615,GO:0007186,GO:0007193,GO:0007268 G-protein coupled receptor binding|neuropeptide hormone activity|extracellular region|extracellular space|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|chemical synaptic transmission hsa03460 Fanconi anemia pathway CENPT 623.5696082603 587.10517819148 660.034038329119 1.12421770893299 0.168921445864801 0.327009161894311 1 5.07802 6.08021 6.19325 6.84649 GeneID:80152,Genbank:NM_025082.3,HGNC:HGNC:25787,MIM:611510 centromere protein T GO:0000278,GO:0000775,GO:0000776,GO:0000777,GO:0000788,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0007059,GO:0007062,GO:0016604,GO:0034080,GO:0042393,GO:0046982,GO:0051276,GO:0051301,GO:0051382,GO:1903394 mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|nuclear nucleosome|DNA binding|nucleus|nucleoplasm|cytosol|chromosome segregation|sister chromatid cohesion|nuclear body|CENP-A containing nucleosome assembly|histone binding|protein heterodimerization activity|chromosome organization|cell division|kinetochore assembly|protein localization to kinetochore involved in kinetochore assembly CENPU 463.99405193735 488.408721299311 439.579382575389 0.900023614250742 -0.151965240427821 0.414590368451954 1 5.57787 4.59386 5.08446 4.22544 GeneID:79682,Genbank:NM_024629.3,HGNC:HGNC:21348,MIM:611511 centromere protein U GO:0000777,GO:0005634,GO:0005654,GO:0005815,GO:0005829,GO:0006351,GO:0006355,GO:0007062,GO:0016032,GO:0034080,GO:0043009 condensed chromosome kinetochore|nucleus|nucleoplasm|microtubule organizing center|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|sister chromatid cohesion|viral process|CENP-A containing nucleosome assembly|chordate embryonic development CENPV 1.95778405814435 3.43049981370153 0.48506830258717 0.141398725821174 -2.82215897516266 0.489190049063716 1 0 0.227574 0.0481525 0 GeneID:201161,Genbank:NM_181716.2,HGNC:HGNC:29920,MIM:608139 centromere protein V GO:0000776,GO:0000777,GO:0001667,GO:0005634,GO:0005737,GO:0007049,GO:0008152,GO:0015630,GO:0016846,GO:0031508,GO:0032467,GO:0033044,GO:0034508,GO:0051233,GO:0051301 kinetochore|condensed chromosome kinetochore|ameboidal-type cell migration|nucleus|cytoplasm|cell cycle|metabolic process|microtubule cytoskeleton|carbon-sulfur lyase activity|pericentric heterochromatin assembly|positive regulation of cytokinesis|regulation of chromosome organization|centromere complex assembly|spindle midzone|cell division CENPW 849.00114984801 814.589276244792 883.413023451227 1.08448889423601 0.117015279093479 0.456543627417632 1 14.783 15.9824 16.1011 17.5634 GeneID:387103,Genbank:XM_017010845.1,HGNC:HGNC:21488,MIM:611264 centromere protein W GO:0000278,GO:0000775,GO:0000776,GO:0000777,GO:0003677,GO:0005654,GO:0005730,GO:0007059,GO:0016363,GO:0034080,GO:0046982,GO:0051276,GO:0051301,GO:0051382 mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|DNA binding|nucleoplasm|nucleolus|chromosome segregation|nuclear matrix|CENP-A containing nucleosome assembly|protein heterodimerization activity|chromosome organization|cell division|kinetochore assembly CENPX 1649.70588791393 1732.75712309197 1566.65465273589 0.904139785003634 -0.145382256382626 0.447221326504207 1 56.4487 57.7378 48.9254 57.6807 GeneID:201254,Genbank:XM_017024329.1,HGNC:HGNC:11422,MIM:615128 centromere protein X GO:0000712,GO:0000777,GO:0003677,GO:0005654,GO:0031297,GO:0031398,GO:0034080,GO:0036297,GO:0043240,GO:0051301,GO:0051382,GO:0071821 resolution of meiotic recombination intermediates|condensed chromosome kinetochore|DNA binding|nucleoplasm|replication fork processing|positive regulation of protein ubiquitination|CENP-A containing nucleosome assembly|interstrand cross-link repair|Fanconi anaemia nuclear complex|cell division|kinetochore assembly|FANCM-MHF complex hsa03460 Fanconi anemia pathway CEP104 814.807056725891 804.268350838364 825.345762613417 1.02620693920516 0.037321686170149 0.798859268066704 1 3.90235 3.6945 4.45915 3.98513 GeneID:9731,Genbank:NM_014704.3,HGNC:HGNC:24866,MIM:616690 centrosomal protein 104 GO:0000922,GO:0005814,GO:0005929,GO:0016594,GO:0016595,GO:0016596 spindle pole|centriole|cilium|glycine binding|glutamate binding|thienylcyclohexylpiperidine binding CEP112 38.8820660728613 35.5918988984008 42.1722332473217 1.18488292427737 0.24474451658453 0.597683487577895 1 0.0906141 0.0665347 0.112247 0.0520911 GeneID:201134,Genbank:NM_001353128.1,HGNC:HGNC:28514 centrosomal protein 112 GO:0005737,GO:0005813,GO:0005886,GO:0060077,GO:0097120 cytoplasm|centrosome|plasma membrane|inhibitory synapse|receptor localization to synapse CEP120 251.690922207926 295.458927100476 207.922917315377 0.703728668332533 -0.506908808504153 0.0199018828062154 0.575358402571021 1.90884 1.66049 1.3979 1.13209 GeneID:153241,Genbank:NM_001166226.1,HGNC:HGNC:26690,MIM:613446 centrosomal protein 120 GO:0005813,GO:0005814,GO:0007098,GO:0008022,GO:0010825,GO:0021987,GO:0022008,GO:0022027,GO:0030953,GO:0032880,GO:0045724 centrosome|centriole|centrosome cycle|protein C-terminus binding|positive regulation of centrosome duplication|cerebral cortex development|neurogenesis|interkinetic nuclear migration|astral microtubule organization|regulation of protein localization|positive regulation of cilium assembly CEP126 17.2208460673939 16.988802934237 17.4528892005508 1.02731718462509 0.0388816831519062 0.99807401679592 1 0.0664607 0.0690629 0.0959801 0.0467701 GeneID:57562,Genbank:NM_020802.3,HGNC:HGNC:29264,MIM:614634 centrosomal protein 126 GO:0005737,GO:0005813,GO:0007052,GO:0030496,GO:0031122,GO:0060271,GO:0097546,GO:1905515 cytoplasm|centrosome|mitotic spindle organization|midbody|cytoplasmic microtubule organization|cilium assembly|ciliary base|non-motile cilium assembly CEP128 80.7848533179329 74.3261399623936 87.2435666734722 1.17379385930191 0.231179065794019 0.489980112288485 1 0.18262 0.210784 0.188865 0.181489 GeneID:145508,Genbank:XM_011536491.2,HGNC:HGNC:20359 centrosomal protein 128 GO:0000922,GO:0005814,GO:0008104,GO:0120103 spindle pole|centriole|protein localization|centriolar subdistal appendage CEP131 596.574782448891 546.179311800486 646.970253097295 1.18453818941723 0.244324711701569 0.145964219298561 1 4.31312 4.15654 4.91031 4.87298 GeneID:22994,Genbank:NM_001009811.3,HGNC:HGNC:29511,MIM:613479 centrosomal protein 131 GO:0000086,GO:0001669,GO:0005813,GO:0005815,GO:0005829,GO:0007275,GO:0007283,GO:0008284,GO:0010389,GO:0010824,GO:0015630,GO:0030154,GO:0032403,GO:0034451,GO:0035735,GO:0035869,GO:0042803,GO:0043231,GO:0045171,GO:0071539,GO:0090316,GO:0097711 G2/M transition of mitotic cell cycle|acrosomal vesicle|centrosome|microtubule organizing center|cytosol|multicellular organism development|spermatogenesis|positive regulation of cell proliferation|regulation of G2/M transition of mitotic cell cycle|regulation of centrosome duplication|microtubule cytoskeleton|cell differentiation|protein complex binding|centriolar satellite|intraciliary transport involved in cilium assembly|ciliary transition zone|protein homodimerization activity|intracellular membrane-bounded organelle|intercellular bridge|protein localization to centrosome|positive regulation of intracellular protein transport|ciliary basal body-plasma membrane docking CEP135 121.122439803322 109.908230205686 132.336649400958 1.20406496541067 0.267913234910969 0.554680165808004 1 0.666706 0.499284 0.936002 0.514946 GeneID:9662,Genbank:NM_025009.4,HGNC:HGNC:29086,MIM:611423 centrosomal protein 135 GO:0000086,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0008022,GO:0010389,GO:0010457,GO:0097711,GO:1902857 G2/M transition of mitotic cell cycle|centrosome|centriole|cytosol|centriole replication|protein C-terminus binding|regulation of G2/M transition of mitotic cell cycle|centriole-centriole cohesion|ciliary basal body-plasma membrane docking|positive regulation of non-motile cilium assembly CEP152 95.4412485320674 88.1245744563537 102.757922607781 1.16605297945212 0.221633338672582 0.460192959195876 1 0.258529 0.213792 0.345417 0.18238 GeneID:22995,Genbank:XM_011521374.3,HGNC:HGNC:29298,MIM:613529 centrosomal protein 152 GO:0000086,GO:0000242,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0010389,GO:0019901,GO:0051298,GO:0097711,GO:0098535,GO:0098536 G2/M transition of mitotic cell cycle|pericentriolar material|nucleoplasm|centrosome|centriole|cytosol|centriole replication|regulation of G2/M transition of mitotic cell cycle|protein kinase binding|centrosome duplication|ciliary basal body-plasma membrane docking|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation|deuterosome CEP162 24.6488047198431 24.5800053370221 24.7176041026641 1.00559799575937 0.00805367946245276 1 1 0.102183 0.105127 0.0896702 0.083276 GeneID:22832,Genbank:NM_001286206.1,HGNC:HGNC:21107,MIM:610201 centrosomal protein 162 GO:0005634,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005879,GO:0060271,GO:0097711 nucleus|centrosome|centriole|spindle|cytosol|axonemal microtubule|cilium assembly|ciliary basal body-plasma membrane docking CEP164 588.697160196773 555.586720987046 621.8075994065 1.11919089481082 0.162456130602514 0.339283371120678 1 1.61254 1.76748 2.09667 1.90926 GeneID:22897,Genbank:XM_017017364.1,HGNC:HGNC:29182,MIM:614848 centrosomal protein 164 GO:0000086,GO:0005615,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0006281,GO:0010389,GO:0043231,GO:0051301,GO:0060271,GO:0097539,GO:0097711 G2/M transition of mitotic cell cycle|extracellular space|nucleoplasm|centrosome|centriole|cytosol|DNA repair|regulation of G2/M transition of mitotic cell cycle|intracellular membrane-bounded organelle|cell division|cilium assembly|ciliary transition fiber|ciliary basal body-plasma membrane docking CEP170 431.23710021329 429.111098663325 433.363101763256 1.00990886302679 0.0142251060544965 0.961133827402439 1 1.39026 1.15193 1.6444 0.957555 GeneID:9859,Genbank:XM_011544341.3,HGNC:HGNC:28920,MIM:613023 centrosomal protein 170 GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005874,GO:0005886,GO:0120103 centrosome|centriole|spindle|cytosol|microtubule|plasma membrane|centriolar subdistal appendage CEP170B 1004.00636979904 918.511805423367 1089.50093417472 1.18615887976806 0.246297264269843 0.109538872814457 1 4.2733 4.12458 5.59814 4.76697 GeneID:283638,Genbank:NM_001112726.2,HGNC:HGNC:20362 centrosomal protein 170B GO:0005737,GO:0005874 cytoplasm|microtubule CEP19 199.511111347272 190.615107048634 208.40711564591 1.09333997117415 0.128742072979785 0.584751845943173 1 3.10494 3.29218 3.87488 3.14746 GeneID:84984,Genbank:XM_011513246.3,HGNC:HGNC:28209,MIM:615586 centrosomal protein 19 GO:0000922,GO:0005813,GO:0005814,GO:0005929,GO:0034454,GO:0036064,GO:0060271,GO:0097712 spindle pole|centrosome|centriole|cilium|microtubule anchoring at centrosome|ciliary basal body|cilium assembly|vesicle targeting, trans-Golgi to periciliary membrane compartment CEP192 439.647077936392 476.522546138495 402.771609734288 0.84523096125913 -0.242582479960822 0.204737801630102 1 1.93904 1.79715 1.84646 1.41344 GeneID:55125,Genbank:XM_011525675.3,HGNC:HGNC:25515,MIM:616426 centrosomal protein 192 GO:0000086,GO:0000242,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0010923,GO:0019902,GO:0071539,GO:0090222,GO:0090307,GO:0097711 G2/M transition of mitotic cell cycle|pericentriolar material|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|negative regulation of phosphatase activity|phosphatase binding|protein localization to centrosome|centrosome-templated microtubule nucleation|mitotic spindle assembly|ciliary basal body-plasma membrane docking CEP250 1159.24937638774 1178.63858230908 1139.86017046639 0.967098979768062 -0.0482645419868784 0.744844915955115 1 2.83769 3.03004 2.9314 2.77985 GeneID:11190,Genbank:XM_006723690.4,HGNC:HGNC:1859,MIM:609689 centrosomal protein 250 GO:0000086,GO:0000278,GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0005929,GO:0008022,GO:0008104,GO:0010389,GO:0010457,GO:0019901,GO:0019904,GO:0030997,GO:0033365,GO:0043234,GO:0048471,GO:0070062,GO:0097711,GO:1904781,GO:1905515 G2/M transition of mitotic cell cycle|mitotic cell cycle|centrosome|centriole|microtubule organizing center|cytosol|cilium|protein C-terminus binding|protein localization|regulation of G2/M transition of mitotic cell cycle|centriole-centriole cohesion|protein kinase binding|protein domain specific binding|regulation of centriole-centriole cohesion|protein localization to organelle|protein complex|perinuclear region of cytoplasm|extracellular exosome|ciliary basal body-plasma membrane docking|positive regulation of protein localization to centrosome|non-motile cilium assembly CEP290 31.5634500332297 30.1727045124008 32.9541955540587 1.09218567200413 0.127218135845189 0.900018372710821 1 0.0412047 0.0979853 0.0772111 0.0687736 GeneID:80184,Genbank:XM_017019983.2,HGNC:HGNC:29021,MIM:610142 centrosomal protein 290 CEP295 86.614667193552 72.8941433760985 100.335191011005 1.37645064972263 0.460952885504312 0.203690473711108 1 0.199791 0.167967 0.317483 0.210268 GeneID:85459,Genbank:NM_033395.1,HGNC:HGNC:29366,MIM:617728 centrosomal protein 295 GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005856,GO:0005886,GO:1902117 cytoplasm|centrosome|centriole|cytosol|cytoskeleton|plasma membrane|positive regulation of organelle assembly CEP295NL 4.96914115593235 5.09281911831339 4.84546319355132 0.951430451579833 -0.0718298938037766 1 1 0.0642041 0.0436096 0.0602793 0.0842766 GeneID:100653515,Genbank:NM_001243540.1,HGNC:HGNC:44659 CEP295 N-terminal like GO:0005929 cilium CEP350 123.519041240524 121.468030098815 125.570052382232 1.03377038616729 0.0479157799237126 0.94474775166564 1 0.285561 0.255672 0.428302 0.149565 GeneID:9857,Genbank:NM_014810.4,HGNC:HGNC:24238,MIM:617870 centrosomal protein 350 GO:0005634,GO:0005813,GO:0005814,GO:0005819,GO:0008017,GO:0016020,GO:0034453,GO:0042995 nucleus|centrosome|centriole|spindle|microtubule binding|membrane|microtubule anchoring|cell projection CEP41 996.363046779941 988.599790556668 1004.12630300321 1.01570555910982 0.0224822426842078 0.885199096452782 1 3.79258 3.8647 3.89647 3.80614 GeneID:95681,Genbank:NM_001257159.1,HGNC:HGNC:12370,MIM:610523 centrosomal protein 41 GO:0000086,GO:0005813,GO:0005814,GO:0005829,GO:0005929,GO:0010389,GO:0015031,GO:0016020,GO:0018095,GO:0036064,GO:0060271,GO:0097711 G2/M transition of mitotic cell cycle|centrosome|centriole|cytosol|cilium|regulation of G2/M transition of mitotic cell cycle|protein transport|membrane|protein polyglutamylation|ciliary basal body|cilium assembly|ciliary basal body-plasma membrane docking CEP44 138.906332436571 151.81322239974 125.999442473402 0.829963559706495 -0.268880099855301 0.324271772984219 1 0.828933 0.676361 0.636585 0.664959 GeneID:80817,Genbank:XM_011532286.2,HGNC:HGNC:29356 centrosomal protein 44 GO:0000922,GO:0005737,GO:0005813,GO:0030496 spindle pole|cytoplasm|centrosome|midbody CEP55 1688.43276744152 1777.93364261629 1598.93189226676 0.89932034241384 -0.153092992394755 0.413580265391718 1 23.2318 20.6911 22.5458 17.4152 GeneID:55165,Genbank:XM_011539919.1,HGNC:HGNC:1161,MIM:610000 centrosomal protein 55 GO:0000281,GO:0000920,GO:0005813,GO:0005814,GO:0005815,GO:0005886,GO:0016020,GO:0030496,GO:0032154,GO:0045171,GO:0045184,GO:0072001,GO:0090543,GO:1904888 mitotic cytokinesis|cell separation after cytokinesis|centrosome|centriole|microtubule organizing center|plasma membrane|membrane|midbody|cleavage furrow|intercellular bridge|establishment of protein localization|renal system development|Flemming body|cranial skeletal system development CEP57 296.614330958469 307.278475677245 285.950186239693 0.930589705671558 -0.10378286702145 0.619109052269237 1 2.17541 2.15685 2.2538 1.84726 GeneID:9702,Genbank:NM_001243776.1,HGNC:HGNC:30794,MIM:607951 centrosomal protein 57 CEP57L1 187.114673192475 195.860796645255 178.368549739695 0.910690412756556 -0.134967398587136 0.761788000001493 1 0.832783 0.534117 0.697452 0.513346 GeneID:285753,Genbank:XM_024446404.1,HGNC:HGNC:21561 centrosomal protein 57 like 1 GO:0000070,GO:0005737,GO:0005813,GO:0005874,GO:0008017,GO:0042802,GO:0043015 mitotic sister chromatid segregation|cytoplasm|centrosome|microtubule|microtubule binding|identical protein binding|gamma-tubulin binding CEP63 151.493996394679 150.794861976248 152.193130813109 1.00927265570283 0.0133159721572987 0.957665149530298 1 0.660418 0.56272 0.708415 0.600745 GeneID:80254,Genbank:NM_001353113.1,HGNC:HGNC:25815,MIM:614724 centrosomal protein 63 GO:0000077,GO:0000086,GO:0000922,GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0010389,GO:0042770,GO:0051225,GO:0051301,GO:0097711,GO:0098535 DNA damage checkpoint|G2/M transition of mitotic cell cycle|spindle pole|centrosome|centriole|cytosol|centriole replication|regulation of G2/M transition of mitotic cell cycle|signal transduction in response to DNA damage|spindle assembly|cell division|ciliary basal body-plasma membrane docking|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation CEP68 177.824141571891 178.26726945033 177.381013693453 0.995028499849639 -0.00719024661509765 0.99669168426672 1 0.855976 0.752018 0.857941 0.754213 GeneID:23177,Genbank:NM_015147.2,HGNC:HGNC:29076,MIM:616889 centrosomal protein 68 GO:0005634,GO:0005813,GO:0005815,GO:0005829,GO:0007098,GO:0010457,GO:0019901,GO:0019904,GO:0030054,GO:0033365 nucleus|centrosome|microtubule organizing center|cytosol|centrosome cycle|centriole-centriole cohesion|protein kinase binding|protein domain specific binding|cell junction|protein localization to organelle CEP70 137.709405251276 143.597678426051 131.821132076502 0.91798929844389 -0.123450759518346 0.660719587699582 1 0.350781 0.36695 0.324988 0.363055 GeneID:80321,Genbank:NM_001288967.1,HGNC:HGNC:29972,MIM:614310 centrosomal protein 70 GO:0000086,GO:0005654,GO:0005813,GO:0005829,GO:0010389,GO:0031965,GO:0042802,GO:0097711 G2/M transition of mitotic cell cycle|nucleoplasm|centrosome|cytosol|regulation of G2/M transition of mitotic cell cycle|nuclear membrane|identical protein binding|ciliary basal body-plasma membrane docking CEP72 225.179553219684 230.329490916541 220.029615522828 0.955281994707984 -0.0660014221438303 0.760469365338359 1 2.78078 2.6179 2.82834 2.46663 GeneID:55722,Genbank:NM_018140.3,HGNC:HGNC:25547,MIM:616475 centrosomal protein 72 GO:0000086,GO:0005813,GO:0005829,GO:0007051,GO:0007099,GO:0010389,GO:0033566,GO:0034451,GO:0042802,GO:0097711,GO:1904779 G2/M transition of mitotic cell cycle|centrosome|cytosol|spindle organization|centriole replication|regulation of G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|centriolar satellite|identical protein binding|ciliary basal body-plasma membrane docking|regulation of protein localization to centrosome CEP76 228.773675653256 237.516865811631 220.030485494881 0.926378363671161 -0.110326536496351 0.619368827584776 1 1.88801 1.90882 1.91004 1.65424 GeneID:79959,Genbank:XM_005258149.5,HGNC:HGNC:25727 centrosomal protein 76 GO:0000086,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0043234,GO:0046599,GO:0097711 G2/M transition of mitotic cell cycle|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|protein complex|regulation of centriole replication|ciliary basal body-plasma membrane docking CEP78 420.442233930988 446.36945893631 394.515008925665 0.883830649762166 -0.17815813268454 0.339376474383879 1 1.35809 1.32059 1.24432 1.13541 GeneID:84131,Genbank:NM_001349839.1,HGNC:HGNC:25740,MIM:617110 centrosomal protein 78 GO:0000086,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0036064,GO:0044782,GO:0097711 G2/M transition of mitotic cell cycle|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|ciliary basal body|cilium organization|ciliary basal body-plasma membrane docking CEP83 47.2517382796436 56.6933781470365 37.8100984122508 0.666922657425507 -0.584408632155839 0.166937010343447 1 0.110394 0.0897509 0.0854269 0.045175 GeneID:51134,Genbank:XM_024449002.1,HGNC:HGNC:17966,MIM:615847 centrosomal protein 83 GO:0005794,GO:0005814,GO:0005829,GO:0048278,GO:0060271,GO:0071539,GO:0097539,GO:0097711 Golgi apparatus|centriole|cytosol|vesicle docking|cilium assembly|protein localization to centrosome|ciliary transition fiber|ciliary basal body-plasma membrane docking CEP85 1641.05275427386 1605.75321174671 1676.35229680102 1.0439663358839 0.0620751909917054 0.684925623746666 1 10.1807 11.4193 11.9431 11.2762 GeneID:64793,Genbank:NM_022778.4,HGNC:HGNC:25309 centrosomal protein 85 GO:0000242,GO:0000922,GO:0005730,GO:0005739,GO:0005794,GO:0005813,GO:0005815,GO:0005829,GO:0006469,GO:0007059,GO:0046602 pericentriolar material|spindle pole|nucleolus|mitochondrion|Golgi apparatus|centrosome|microtubule organizing center|cytosol|negative regulation of protein kinase activity|chromosome segregation|regulation of mitotic centrosome separation CEP85L 66.3589116894439 63.8807530421262 68.8370703367617 1.07758702048122 0.107804378778347 0.848003366466658 1 0.282656 0.173833 0.328769 0.153101 GeneID:387119,Genbank:XM_011535810.2,HGNC:HGNC:21638 centrosomal protein 85 like GO:0005737,GO:0005813 cytoplasm|centrosome CEP89 642.902751486334 644.663029282846 641.142473689822 0.994538921214482 -0.00790026294914422 0.95447111717897 1 2.87519 3.01147 3.03034 3.02831 GeneID:84902,Genbank:XM_005259344.3,HGNC:HGNC:25907,MIM:615470 centrosomal protein 89 GO:0000922,GO:0005758,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0007005,GO:0007268,GO:0031514,GO:0060271,GO:0097539,GO:0097711,GO:0097730,GO:1905515 spindle pole|mitochondrial intermembrane space|centrosome|centriole|cytosol|plasma membrane|mitochondrion organization|chemical synaptic transmission|motile cilium|cilium assembly|ciliary transition fiber|ciliary basal body-plasma membrane docking|non-motile cilium|non-motile cilium assembly CEP95 284.325599361116 276.433403319255 292.217795402976 1.05710016189864 0.0801120808154761 0.691061977432166 1 1.01137 1.02255 0.966482 1.08389 GeneID:90799,Genbank:NM_138363.2,HGNC:HGNC:25141 centrosomal protein 95 GO:0000922,GO:0005737,GO:0005813 spindle pole|cytoplasm|centrosome CEP97 155.31803623944 183.148366159687 127.487706319193 0.696089782248104 -0.522654696786924 0.168492305746433 1 1.00862 0.812569 0.833287 0.466857 GeneID:79598,Genbank:XM_006713743.4,HGNC:HGNC:26244,MIM:615864 centrosomal protein 97 GO:0005516,GO:0005813,GO:0005815,GO:0005829,GO:0043234,GO:0097711,GO:1901673,GO:1902018 calmodulin binding|centrosome|microtubule organizing center|cytosol|protein complex|ciliary basal body-plasma membrane docking|regulation of mitotic spindle assembly|negative regulation of cilium assembly CEPT1 506.595582433228 509.18382528026 504.007339586196 0.989833758581757 -0.0147418482896823 0.956763059929575 1 7.32198 6.79771 7.59556 7.23495 GeneID:10390,Genbank:NM_001007794.2,HGNC:HGNC:24289,MIM:616751 choline/ethanolamine phosphotransferase 1 GO:0004142,GO:0004307,GO:0005789,GO:0006629,GO:0006646,GO:0006656,GO:0016021,GO:0031965,GO:0046872 diacylglycerol cholinephosphotransferase activity|ethanolaminephosphotransferase activity|endoplasmic reticulum membrane|lipid metabolic process|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|integral component of membrane|nuclear membrane|metal ion binding hsa00440,hsa00564,hsa00565 Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Ether lipid metabolism CERCAM 872.803672419299 826.793035019041 918.814309819557 1.1112990445044 0.152247090327878 0.333420169433903 1 5.01014 5.19178 5.63287 6.09952 GeneID:51148,Genbank:XM_017014794.2,HGNC:HGNC:23723,MIM:616626 cerebral endothelial cell adhesion molecule GO:0005788,GO:0005886,GO:0006928,GO:0007155,GO:0007159 endoplasmic reticulum lumen|plasma membrane|movement of cell or subcellular component|cell adhesion|leukocyte cell-cell adhesion CERK 1919.66003852161 1927.06923629049 1912.25084075273 0.992310397956288 -0.0111366239256371 0.938941066886063 1 18.9778 18.5638 18.4984 19.2608 GeneID:64781,Genbank:NM_022766.5,HGNC:HGNC:19256,MIM:610307 ceramide kinase GO:0000287,GO:0001729,GO:0003951,GO:0005524,GO:0005739,GO:0005886,GO:0006672,GO:0006687,GO:0016021,GO:0102773 magnesium ion binding|ceramide kinase activity|NAD+ kinase activity|ATP binding|mitochondrion|plasma membrane|ceramide metabolic process|glycosphingolipid metabolic process|integral component of membrane|dihydroceramide kinase activity hsa00600 Sphingolipid metabolism CERKL 5.55026200788941 5.28492421705316 5.81559979872566 1.10041309200994 0.138045209130131 0.966023192990189 1 0.09675 0.0133084 0.0800768 0.0743308 GeneID:375298,Genbank:NM_001030312.2,HGNC:HGNC:21699,MIM:608381 ceramide kinase like GO:0001750,GO:0001917,GO:0003951,GO:0005634,GO:0005730,GO:0005737,GO:0005783,GO:0005794,GO:0005829,GO:0030148,GO:0043066,GO:0046625,GO:0048471 photoreceptor outer segment|photoreceptor inner segment|NAD+ kinase activity|nucleus|nucleolus|cytoplasm|endoplasmic reticulum|Golgi apparatus|cytosol|sphingolipid biosynthetic process|negative regulation of apoptotic process|sphingolipid binding|perinuclear region of cytoplasm CERS1 34.6503897960265 24.7240841610769 44.576695430976 1.80296649779056 0.85037258927138 0.0778266086142968 0.94157495521624 0.865547 0.96921 1.12014 1.8266 GeneID:10715,Genbank:NM_021267.4,HGNC:HGNC:14253,MIM:606919 ceramide synthase 1 GO:0000139,GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0030148,GO:0035690,GO:0036146,GO:0043231,GO:0046513,GO:0050291,GO:0051974,GO:0071492,GO:0072721 Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|sphingolipid biosynthetic process|cellular response to drug|cellular response to mycotoxin|intracellular membrane-bounded organelle|ceramide biosynthetic process|sphingosine N-acyltransferase activity|negative regulation of telomerase activity|cellular response to UV-A|cellular response to dithiothreitol hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway CERS2 6679.03680451116 6556.3541925888 6801.71941643352 1.03742403424789 0.0530056984582743 0.695361778074451 1 103.15 104.527 113.737 107.272 GeneID:29956,Genbank:NM_022075.4,HGNC:HGNC:14076,MIM:606920 ceramide synthase 2 GO:0003677,GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0030148,GO:0031965,GO:0046513,GO:0048681,GO:0050291,GO:1900148,GO:1905045 DNA binding|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|sphingolipid biosynthetic process|nuclear membrane|ceramide biosynthetic process|negative regulation of axon regeneration|sphingosine N-acyltransferase activity|negative regulation of Schwann cell migration|negative regulation of Schwann cell proliferation involved in axon regeneration hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway CERS4 641.658532098362 586.969891021679 696.347173175046 1.18634223633343 0.246520258987363 0.168396480313924 1 6.10464 6.04767 6.69211 7.69409 GeneID:79603,Genbank:XM_011528294.2,HGNC:HGNC:23747,MIM:615334 ceramide synthase 4 GO:0003677,GO:0005783,GO:0005789,GO:0016021,GO:0030148,GO:0031965,GO:0046513,GO:0050291 DNA binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|sphingolipid biosynthetic process|nuclear membrane|ceramide biosynthetic process|sphingosine N-acyltransferase activity hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway CERS5 963.824986947471 893.518163923542 1034.1318099714 1.1573707751283 0.210851120060796 0.16998432487963 1 7.91638 7.27908 8.60841 9.11658 GeneID:91012,Genbank:NM_147190.3,HGNC:HGNC:23749,MIM:615335 ceramide synthase 5 GO:0003677,GO:0005783,GO:0005789,GO:0016021,GO:0030148,GO:0031965,GO:0046513,GO:0050291 DNA binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|sphingolipid biosynthetic process|nuclear membrane|ceramide biosynthetic process|sphingosine N-acyltransferase activity hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway CERS6 606.029138710719 603.812581130151 608.245696291287 1.00734187279245 0.010553389877312 0.934572204423165 1 2.51421 1.88157 2.40346 2.01337 GeneID:253782,Genbank:XM_024452780.1,HGNC:HGNC:23826,MIM:615336 ceramide synthase 6 GO:0003677,GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0030148,GO:0031965,GO:0046513,GO:0050291 DNA binding|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|sphingolipid biosynthetic process|nuclear membrane|ceramide biosynthetic process|sphingosine N-acyltransferase activity hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway CES2 1285.85283549825 1269.57033200909 1302.13533898742 1.02565041585904 0.0365390845050871 0.828399464263256 1 10.0474 10.8532 10.4714 11.1438 GeneID:8824,Genbank:NM_003869.5,HGNC:HGNC:1864,MIM:605278 carboxylesterase 2 hsa00983 Drug metabolism - other enzymes CES3 5.94341088842349 6.07296192222811 5.81385985461886 0.957335140426142 -0.0629040282857778 1 1 0.0398781 0.0176055 0.0185545 0.0260925 GeneID:23491,Genbank:NM_024922.5,HGNC:HGNC:1865,MIM:605279 carboxylesterase 3 CETN2 784.199581198077 819.220432925617 749.178729470538 0.914502006248861 -0.128941759902865 0.426007674019193 1 28.8743 27.6839 24.5946 27.9607 GeneID:1069,Genbank:NM_004344.1,HGNC:HGNC:1867,MIM:300006 centrin 2 hsa03420 Nucleotide excision repair CETN3 373.865762208984 406.068951117075 341.662573300892 0.841390538136431 -0.249152500527276 0.194007049800726 1 9.24732 7.86485 7.32195 6.54232 GeneID:1070,Genbank:NM_001297768.1,HGNC:HGNC:1868,MIM:602907 centrin 3 GO:0005509,GO:0005730,GO:0005813,GO:0005814,GO:0007098,GO:0051301 calcium ion binding|nucleolus|centrosome|centriole|centrosome cycle|cell division CETP 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:1071,Genbank:NM_000078.2,HGNC:HGNC:1869,MIM:118470 cholesteryl ester transfer protein hsa04979 Cholesterol metabolism CFAP126 12.9112831194977 14.682524748505 11.1400414904904 0.758727921887186 -0.398345463680219 0.789532490678708 1 0 0 0 0 GeneID:257177,Genbank:NM_001013625.3,HGNC:HGNC:32325,MIM:616119 cilia and flagella associated protein 126 GO:0005737,GO:0005929,GO:0016324,GO:0036064,GO:0044782 cytoplasm|cilium|apical plasma membrane|ciliary basal body|cilium organization CFAP157 7.69700749077042 8.12930007942745 7.26471490211339 0.893645803591131 -0.162224962199216 0.938576873927388 1 0 0.0249125 0 0 GeneID:286207,Genbank:XM_011518559.3,HGNC:HGNC:27843 cilia and flagella associated protein 157 GO:0005829,GO:0005886,GO:0007288,GO:0008017,GO:0036064,GO:0043231 cytosol|plasma membrane|sperm axoneme assembly|microtubule binding|ciliary basal body|intracellular membrane-bounded organelle CFAP161 1.02816907859967 2.05633815719933 0 0 -Inf 0.409782672813165 1 0.0194527 0.0182667 0 0 GeneID:161502,Genbank:XM_006720408.2,HGNC:HGNC:26782 cilia and flagella associated protein 161 CFAP20 1410.85622067449 1452.21002645746 1369.50241489151 0.94304707304101 -0.0845983087718774 0.544080468126109 1 45.8849 51.1871 44.1116 46.6047 GeneID:29105,Genbank:NM_013242.2,HGNC:HGNC:29523,MIM:617906 cilia and flagella associated protein 20 GO:0003723,GO:0005634,GO:0005814,GO:0005874,GO:0005929,GO:0007275,GO:0018095,GO:0036064,GO:0060271,GO:0060296,GO:0070062,GO:2000147,GO:2000253 RNA binding|nucleus|centriole|microtubule|cilium|multicellular organism development|protein polyglutamylation|ciliary basal body|cilium assembly|regulation of cilium beat frequency involved in ciliary motility|extracellular exosome|positive regulation of cell motility|positive regulation of feeding behavior CFAP206 5.72956635429096 6.61105959887042 4.84807310971151 0.733327696900488 -0.447470065632536 0.768758567530756 1 0.0676331 0.129266 0.113784 0.0451926 GeneID:154313,Genbank:NM_001031743.2,HGNC:HGNC:21405 cilia and flagella associated protein 206 GO:0001534,GO:0003341,GO:0031514,GO:0035082 radial spoke|cilium movement|motile cilium|axoneme assembly CFAP221 2.21258520393323 1.51824048055703 2.90692992730943 1.91467028085228 0.937095971714222 0.766567103099927 1 0 0.0106833 0.00540508 0.0151109 GeneID:200373,Genbank:XM_006712353.3,HGNC:HGNC:33720 cilia and flagella associated protein 221 GO:0003341,GO:0005516,GO:0005929,GO:0005930,GO:0044458,GO:0060271 cilium movement|calmodulin binding|cilium|axoneme|motile cilium assembly|cilium assembly CFAP298 132.303311799573 149.748092588288 114.858531010858 0.767011646196033 -0.382679611315996 0.139636612336709 1 6.43978 7.12125 5.67902 5.52326 GeneID:56683,Genbank:NM_021254.3,HGNC:HGNC:1301,MIM:615494 cilia and flagella associated protein 298 GO:0003352,GO:0005634,GO:0005829,GO:0005856,GO:0005929,GO:0048858,GO:0060271 regulation of cilium movement|nucleus|cytosol|cytoskeleton|cilium|cell projection morphogenesis|cilium assembly CFAP299 0.972638154859436 0.490071401957362 1.45520490776151 2.96937324224464 1.5701584476161 0.837389832160054 1 0 0 0.0180231 0 GeneID:255119,Genbank:XM_017007976.1,HGNC:HGNC:28554 cilia and flagella associated protein 299 CFAP36 423.614568610691 392.636126511234 454.593010710149 1.15779720717356 0.211382581629576 0.248268391194582 1 3.48111 4.02939 4.65587 4.30907 GeneID:112942,Genbank:NM_001282761.1,HGNC:HGNC:30540 cilia and flagella associated protein 36 GO:0005634,GO:0005737,GO:0035869,GO:0047485,GO:0097546 nucleus|cytoplasm|ciliary transition zone|protein N-terminus binding|ciliary base CFAP43 6.03826684618837 5.77499561901052 6.30153807336622 1.0911762517399 0.12588415113353 0.972437975840659 1 0.0293842 0.0056989 0.0341797 0.0158128 GeneID:80217,Genbank:NM_025145.6,HGNC:HGNC:26684,MIM:617558 cilia and flagella associated protein 43 GO:0042995 cell projection CFAP44 31.5758512065897 37.4561319568604 25.6955704563191 0.686017725640052 -0.543682240992748 0.313062903958947 1 0.0919851 0.0985767 0.0984371 0.0383915 GeneID:55779,Genbank:NM_001164496.1,HGNC:HGNC:25631,MIM:617559 cilia and flagella associated protein 44 GO:0042995,GO:0060285 cell projection|cilium-dependent cell motility CFAP45 31.7200495119048 37.754098260078 25.6860007637317 0.680350000330762 -0.555650975234396 0.268376588259583 1 0.394317 0.58834 0.308443 0.301144 GeneID:25790,Genbank:NM_012337.2,HGNC:HGNC:17229,MIM:605152 cilia and flagella associated protein 45 GO:0005634,GO:0005654,GO:0005929 nucleus|nucleoplasm|cilium CFAP46 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0099489 0 0 0 GeneID:54777,Genbank:NM_001200049.2,HGNC:HGNC:25247 cilia and flagella associated protein 46 GO:0005930,GO:0035082,GO:0060294 axoneme|axoneme assembly|cilium movement involved in cell motility CFAP47 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00352237 0 0 0 GeneID:286464,Genbank:NM_001304548.1,HGNC:HGNC:26708 cilia and flagella associated protein 47 CFAP52 0.974269732491135 0.980142803914724 0.968396661067546 0.988015886256305 -0.0173938558720137 1 1 0 0.0316415 0 0.0151915 GeneID:146845,Genbank:NM_145054.4,HGNC:HGNC:16053,MIM:609804 cilia and flagella associated protein 52 GO:0005737,GO:0042995 cytoplasm|cell projection CFAP53 7.79947646406569 8.81147658012458 6.78747634800679 0.77029953904852 -0.376508532888661 0.782179270000264 1 0.106106 0.0289792 0.0728109 0.0269263 GeneID:220136,Genbank:NM_145020.4,HGNC:HGNC:26530,MIM:614759 cilia and flagella associated protein 53 GO:0003341,GO:0005929,GO:0007368,GO:0060271,GO:0060287 cilium movement|cilium|determination of left/right symmetry|cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry CFAP54 5.17678599908969 3.084507235799 7.26906476238037 2.35663728650564 1.23672972836861 0.37997651698201 1 0.00602933 0.00293329 0.0145824 0.0108532 GeneID:144535,Genbank:XM_011539069.3,HGNC:HGNC:26456 cilia and flagella associated protein 54 GO:0005930,GO:0007283,GO:0030154,GO:0060271,GO:0060294 axoneme|spermatogenesis|cell differentiation|cilium assembly|cilium movement involved in cell motility CFAP57 2.98777894647223 1.61429302992691 4.36126486301754 2.70165625581311 1.43384412559572 0.469417698480439 1 0.00546529 0 0.0104296 0.0145723 GeneID:149465,Genbank:NM_001195831.2,HGNC:HGNC:26485,MIM:614259 cilia and flagella associated protein 57 CFAP58 9.81529299563536 14.2983145510254 5.33227144024528 0.372930069569834 -1.42302296774012 0.13126029448137 1 0.0333342 0.0632935 0.0319652 0.0148519 GeneID:159686,Genbank:XM_011539377.2,HGNC:HGNC:26676 cilia and flagella associated protein 58 GO:0005615,GO:0005929 extracellular space|cilium CFAP61 1.5397520682144 2.59443583384164 0.48506830258717 0.186964848488436 -2.41916104230609 0.49972398725951 1 0.0130929 0 0.00416472 0 GeneID:26074,Genbank:XM_011529211.1,HGNC:HGNC:15872 cilia and flagella associated protein 61 GO:0003341,GO:0005930,GO:0031514,GO:0044782 cilium movement|axoneme|motile cilium|cilium organization CFAP69 12.4727274750977 12.338028943196 12.6074260069994 1.02183469215737 0.0311618224060979 1 1 0.0359937 0.0314395 0.0504571 0.00360914 GeneID:79846,Genbank:NM_001039706.2,HGNC:HGNC:26107 cilia and flagella associated protein 69 CFAP70 14.6498800183929 12.338028943196 16.9617310935898 1.37475209141438 0.459171481376808 0.561317914640671 1 0.0362666 0.0520704 0.0639003 0.070364 GeneID:118491,Genbank:XM_017015627.1,HGNC:HGNC:30726 cilia and flagella associated protein 70 GO:0005929,GO:0070062 cilium|extracellular exosome CFAP73 69.7661518968488 74.6044889553953 64.9278148383022 0.870293674649007 -0.200425784193518 0.69461425634408 1 0.318257 0.0525864 0.240316 0.328295 GeneID:387885,Genbank:XM_024448978.1,HGNC:HGNC:37100 cilia and flagella associated protein 73 GO:0003341,GO:0031514,GO:0036159,GO:0070840,GO:0097545,GO:2000574 cilium movement|motile cilium|inner dynein arm assembly|dynein complex binding|axonemal outer doublet|regulation of microtubule motor activity CFAP74 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0 0.00452379 0 GeneID:85452,Genbank:NM_001304360.1,HGNC:HGNC:29368 cilia and flagella associated protein 74 GO:0005930,GO:0035082 axoneme|axoneme assembly CFAP77 1.48585272210587 1.51824048055703 1.45346496365472 0.957335140426142 -0.0629040282857778 1 1 0.0153805 0.0135815 0 0.0133769 GeneID:389799,Genbank:XM_011518670.2,HGNC:HGNC:33776 cilia and flagella associated protein 77 GO:0005929 cilium CFAP97 405.398762867988 411.92038197524 398.877143760736 0.9683355357364 -0.0464210557911432 0.871374437571258 1 2.03532 1.64032 2.01308 1.62826 GeneID:57587,Genbank:XM_017008483.2,HGNC:HGNC:29276,MIM:616047 cilia and flagella associated protein 97 CFAP97D1 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0.0174097 0.0162162 0 0 GeneID:284067,Genbank:XM_011524633.1,HGNC:HGNC:37241 CFAP97 domain containing 1 CFAP99 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0353669 GeneID:402160,Genbank:XM_024454046.1,HGNC:HGNC:51180 cilia and flagella associated protein 99 GO:0042995 cell projection CFB 75.9134332161769 80.1011355814041 71.7257308509498 0.895439625547597 -0.15933193220087 0.651255609335911 1 0.882443 0.920324 0.83472 0.810619 GeneID:629,Genbank:NM_001710.5,HGNC:HGNC:1037,MIM:138470 complement factor B hsa04610,hsa05150 Complement and coagulation cascades|Staphylococcus aureus infection CFD 13.2166216843155 11.8959838159236 14.5372595527073 1.22203087845902 0.289280739851295 0.741052891760919 1 0.61634 0.563008 0.686052 0.868675 GeneID:1675,Genbank:NM_001317335.1,HGNC:HGNC:2771,MIM:134350 complement factor D hsa04610,hsa05150 Complement and coagulation cascades|Staphylococcus aureus infection CFDP1 589.906548947045 631.72805073236 548.085047161731 0.867596502207458 -0.204903858218954 0.23344140672335 1 8.74207 8.51726 7.31644 7.94735 GeneID:10428,Genbank:NM_006324.2,HGNC:HGNC:1873,MIM:608108 craniofacial development protein 1 GO:0000777,GO:0007155,GO:0007275,GO:0008360,GO:0042127,GO:2000270 condensed chromosome kinetochore|cell adhesion|multicellular organism development|regulation of cell shape|regulation of cell proliferation|negative regulation of fibroblast apoptotic process CFH 130.36976333987 128.905345022438 131.834181657303 1.02272083158658 0.0324123915642904 0.89644913319133 1 0.913778 0.770708 0.955774 0.702287 GeneID:3075,Genbank:NM_000186.3,HGNC:HGNC:4883,MIM:134370 complement factor H hsa04610,hsa05150 Complement and coagulation cascades|Staphylococcus aureus infection CFHR1 0.972203168832738 0.490071401957362 1.45433493570811 2.96759804775273 1.56929569647876 0.837430708298891 1 0.0279658 0.0267155 0.0535126 0 GeneID:3078,Genbank:XM_011509457.2,HGNC:HGNC:4888,MIM:134371 complement factor H related 1 GO:0005576,GO:0005615,GO:0006956,GO:0030449,GO:0032091,GO:0042803,GO:0043234,GO:0045919,GO:0046982,GO:0070062,GO:0072562 extracellular region|extracellular space|complement activation|regulation of complement activation|negative regulation of protein binding|protein homodimerization activity|protein complex|positive regulation of cytolysis|protein heterodimerization activity|extracellular exosome|blood microparticle CFHR2 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0 0 0 GeneID:3080,Genbank:XM_011509460.2,HGNC:HGNC:4890,MIM:600889 complement factor H related 2 GO:0005576,GO:0030449,GO:0032091,GO:0042803,GO:0043234,GO:0045919,GO:0046982 extracellular region|regulation of complement activation|negative regulation of protein binding|protein homodimerization activity|protein complex|positive regulation of cytolysis|protein heterodimerization activity CFHR3 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0542582 0 GeneID:10878,Genbank:NM_021023.5,HGNC:HGNC:16980,MIM:605336 complement factor H related 3 GO:0005615,GO:0070062,GO:0072562 extracellular space|extracellular exosome|blood microparticle CFI 780.110159728542 763.025917834791 797.194401622294 1.04478024007947 0.0631995165749554 0.668872163819511 1 8.51786 7.8819 8.51432 8.62006 GeneID:3426,Genbank:XM_017008165.2,HGNC:HGNC:5394,MIM:217030 complement factor I hsa04610,hsa05150 Complement and coagulation cascades|Staphylococcus aureus infection CFL1 24388.5641771832 23767.8694687897 25009.2588855766 1.05222973049465 0.0734497187580833 0.583785972829069 1 753.993 806.81 795.995 873.038 GeneID:1072,Genbank:NM_005507.2,HGNC:HGNC:1874,MIM:601442 cofilin 1 hsa04360,hsa04666,hsa04810,hsa05133,hsa05170 Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Pertussis|Human immunodeficiency virus 1 infection CFL2 1133.10904160949 1306.69805469655 959.520028522423 0.734308913274725 -0.445540982917847 0.00303129742519687 0.206592593880652 16.7892 17.2826 12.2885 12.8658 GeneID:1073,Genbank:NM_138638.4,HGNC:HGNC:1875,MIM:601443 cofilin 2 hsa04360,hsa04666,hsa04810,hsa05133,hsa05170 Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Pertussis|Human immunodeficiency virus 1 infection CFLAR 844.384948682779 810.110990042275 878.658907323283 1.08461546395937 0.117183644909284 0.448735163126171 1 1.3736 1.26927 1.62778 1.32803 GeneID:8837,Genbank:NM_001351590.1,HGNC:HGNC:1876,MIM:603599 CASP8 and FADD like apoptosis regulator GO:0003964,GO:0006310,GO:0009036,GO:0032197,GO:0032199,GO:0046872,GO:0090305 RNA-directed DNA polymerase activity|DNA recombination|Type II site-specific deoxyribonuclease activity|transposition, RNA-mediated|reverse transcription involved in RNA-mediated transposition|metal ion binding|nucleic acid phosphodiester bond hydrolysis hsa04064,hsa04140,hsa04210,hsa04217,hsa04668,hsa05142 NF-kappa B signaling pathway|Autophagy - animal|Apoptosis|Necroptosis|TNF signaling pathway|Chagas disease (American trypanosomiasis) CFP 1.76033964582391 3.03648096111406 0.484198330533773 0.15946035451384 -2.64873031325362 0.397094287453316 1 0.0183185 0.0161185 0 0.0159143 GeneID:5199,Genbank:NM_002621.2,HGNC:HGNC:8864,MIM:300383 complement factor properdin hsa05168 Herpes simplex infection CGA 1.22224196918161 1.96028560782945 0.484198330533773 0.247003971564076 -2.01739385587201 0.637784766456736 1 0 0.262307 0 0 GeneID:1081,Genbank:NM_000735.3,HGNC:HGNC:1885,MIM:118850 glycoprotein hormones, alpha polypeptide hsa04080,hsa04912,hsa04913,hsa04917,hsa04918,hsa04923,hsa05320 Neuroactive ligand-receptor interaction|GnRH signaling pathway|Ovarian steroidogenesis|Prolactin signaling pathway|Thyroid hormone synthesis|Regulation of lipolysis in adipocytes|Autoimmune thyroid disease CGAS 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0 0.0253456 0.0257995 0 GeneID:115004,Genbank:NM_138441.2,HGNC:HGNC:21367,MIM:613973 cyclic GMP-AMP synthase GO:0002218,GO:0002230,GO:0003677,GO:0003682,GO:0003690,GO:0005524,GO:0005525,GO:0005829,GO:0006974,GO:0009190,GO:0032481,GO:0038001,GO:0045087,GO:0046872,GO:0051607,GO:0061501,GO:0071360,GO:2000774 activation of innate immune response|positive regulation of defense response to virus by host|DNA binding|chromatin binding|double-stranded DNA binding|ATP binding|GTP binding|cytosol|cellular response to DNA damage stimulus|cyclic nucleotide biosynthetic process|positive regulation of type I interferon production|paracrine signaling|innate immune response|metal ion binding|defense response to virus|cyclic-GMP-AMP synthase activity|cellular response to exogenous dsRNA|positive regulation of cellular senescence hsa04623,hsa05163,hsa05170 Cytosolic DNA-sensing pathway|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection CGB2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0466095 0 0 GeneID:114336,Genbank:NM_033378.1,HGNC:HGNC:16722,MIM:608824 chorionic gonadotropin beta subunit 2 GO:0005179,GO:0005615,GO:0005737,GO:0007186,GO:0007267,GO:0009755,GO:0030728 hormone activity|extracellular space|cytoplasm|G-protein coupled receptor signaling pathway|cell-cell signaling|hormone-mediated signaling pathway|ovulation CGB5 1.21093081236113 0 2.42186162472226 Inf Inf 0.339679181581212 1 0 0 0.0682814 0.127553 GeneID:93659,Genbank:NM_033043.1,HGNC:HGNC:16452,MIM:608825 chorionic gonadotropin beta subunit 5 GO:0005179,GO:0005615,GO:0005737,GO:0007186,GO:0007267,GO:0009755,GO:0030728 hormone activity|extracellular space|cytoplasm|G-protein coupled receptor signaling pathway|cell-cell signaling|hormone-mediated signaling pathway|ovulation CGB7 2.05090007180244 3.13253351048394 0.969266633120943 0.309419398029425 -1.69236445025423 0.550191620909098 1 0.0619063 0.052431 0.0283205 0.0265401 GeneID:94027,Genbank:XM_024451784.1,HGNC:HGNC:16451,MIM:608826 chorionic gonadotropin beta subunit 7 GO:0005179,GO:0005576,GO:0006915,GO:0007165,GO:0007267,GO:0007292 hormone activity|extracellular region|apoptotic process|signal transduction|cell-cell signaling|female gamete generation CGB8 3.7018094477776 3.52655236307142 3.87706653248377 1.0993928725071 0.136707031357513 1 1 0.0725716 0.0616215 0.266524 0 GeneID:94115,Genbank:NM_033183.2,HGNC:HGNC:16453,MIM:608827 chorionic gonadotropin beta subunit 8 GO:0005179,GO:0005615,GO:0005737,GO:0007186,GO:0007267,GO:0009755,GO:0030728 hormone activity|extracellular space|cytoplasm|G-protein coupled receptor signaling pathway|cell-cell signaling|hormone-mediated signaling pathway|ovulation CGGBP1 1463.07558969608 1595.67917536625 1330.47200402592 0.833796683296653 -0.262232461528524 0.213160640546014 1 15.4652 13.908 14.5594 10.334 GeneID:8545,Genbank:NM_001195308.1,HGNC:HGNC:1888,MIM:603363 CGG triplet repeat binding protein 1 GO:0000122,GO:0000977,GO:0001227,GO:0003690,GO:0005634,GO:0005654,GO:0006351,GO:0042802 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|double-stranded DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|identical protein binding CGN 289.874140614216 278.79751643478 300.950764793652 1.07945999176092 0.110309773459776 0.595061789865612 1 1.70479 1.756 1.93964 1.87918 GeneID:57530,Genbank:XM_005245365.5,HGNC:HGNC:17429,MIM:609473 cingulin GO:0003774,GO:0003779,GO:0005886,GO:0005923,GO:0007179,GO:0016459,GO:0030054,GO:0045296 motor activity|actin binding|plasma membrane|bicellular tight junction|transforming growth factor beta receptor signaling pathway|myosin complex|cell junction|cadherin binding hsa04530 Tight junction CGNL1 1534.15955463157 1563.95204675543 1504.36706250771 0.96190101584551 -0.0560396533828532 0.701380046027947 1 5.45123 5.50379 5.82421 4.89041 GeneID:84952,Genbank:XM_005254726.4,HGNC:HGNC:25931,MIM:607856 cingulin like 1 GO:0003774,GO:0005923,GO:0007015,GO:0016459,GO:0051058 motor activity|bicellular tight junction|actin filament organization|myosin complex|negative regulation of small GTPase mediated signal transduction hsa04530 Tight junction CGREF1 4.00194108646981 5.58289052027075 2.42099165266886 0.433644837540438 -1.2054141602599 0.466361374681623 1 0.0152545 0.0271558 0 0.0266915 GeneID:10669,Genbank:NM_001301324.1,HGNC:HGNC:16962,MIM:606137 cell growth regulator with EF-hand domain 1 GO:0005509,GO:0005576,GO:0006950,GO:0007050,GO:0007155,GO:0008285 calcium ion binding|extracellular region|response to stress|cell cycle arrest|cell adhesion|negative regulation of cell proliferation CGRRF1 162.626749072578 173.088206437754 152.165291707401 0.879119928729067 -0.185868104967495 0.448654752471316 1 2.68088 3.02894 2.36492 2.5382 GeneID:10668,Genbank:NM_006568.2,HGNC:HGNC:15528,MIM:606138 cell growth regulator with ring finger domain 1 GO:0005654,GO:0005783,GO:0006950,GO:0007050,GO:0008285,GO:0043231,GO:0046872 nucleoplasm|endoplasmic reticulum|response to stress|cell cycle arrest|negative regulation of cell proliferation|intracellular membrane-bounded organelle|metal ion binding CH25H 6.71947460301588 6.169014471598 7.26993473443377 1.17845966611108 0.236902381840253 0.8999296622988 1 0.292229 0.264655 0.361932 0.252932 GeneID:9023,Genbank:NM_003956.3,HGNC:HGNC:1907,MIM:604551 cholesterol 25-hydroxylase GO:0001567,GO:0005506,GO:0005789,GO:0005829,GO:0006629,GO:0006699,GO:0008203,GO:0008395,GO:0016021,GO:0016126,GO:0035754 cholesterol 25-hydroxylase activity|iron ion binding|endoplasmic reticulum membrane|cytosol|lipid metabolic process|bile acid biosynthetic process|cholesterol metabolic process|steroid hydroxylase activity|integral component of membrane|sterol biosynthetic process|B cell chemotaxis hsa00120 Primary bile acid biosynthesis CHAC1 670.121452389981 766.554504199572 573.688400580389 0.748398708033721 -0.41812102684174 0.164105240453384 1 5.3651 6.03896 3.35237 5.15593 GeneID:79094,Genbank:XM_024450045.1,HGNC:HGNC:28680,MIM:614587 ChaC glutathione specific gamma-glutamylcyclotransferase 1 GO:0003839,GO:0005112,GO:0005802,GO:0005829,GO:0006750,GO:0006751,GO:0006986,GO:0007219,GO:0010955,GO:0016829,GO:0022008,GO:0045746,GO:0070059 gamma-glutamylcyclotransferase activity|Notch binding|trans-Golgi network|cytosol|glutathione biosynthetic process|glutathione catabolic process|response to unfolded protein|Notch signaling pathway|negative regulation of protein processing|lyase activity|neurogenesis|negative regulation of Notch signaling pathway|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress hsa00480 Glutathione metabolism CHAC2 142.820543344797 166.429120564199 119.211966125395 0.716292712004148 -0.481378831615594 0.0608236875002716 0.88260138524454 4.17996 4.77454 2.60072 3.08422 GeneID:494143,Genbank:NM_001346127.1,HGNC:HGNC:32363,MIM:617446 ChaC cation transport regulator homolog 2 GO:0003839,GO:0005737,GO:0005829,GO:0006750,GO:0006751,GO:0016829 gamma-glutamylcyclotransferase activity|cytoplasm|cytosol|glutathione biosynthetic process|glutathione catabolic process|lyase activity hsa00480 Glutathione metabolism CHAD 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0 0 0 0 GeneID:1101,Genbank:XM_011524214.2,HGNC:HGNC:1909,MIM:602178 chondroadherin GO:0004860,GO:0005578,GO:0005737,GO:0006469,GO:0019221,GO:0046426,GO:0060348,GO:1900155 protein kinase inhibitor activity|proteinaceous extracellular matrix|cytoplasm|negative regulation of protein kinase activity|cytokine-mediated signaling pathway|negative regulation of JAK-STAT cascade|bone development|negative regulation of bone trabecula formation hsa04151,hsa04510,hsa04512,hsa05165 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Human papillomavirus infection CHADL 11.9639726547197 12.7800740704684 11.1478712389709 0.872285338684453 -0.197127953729314 0.855235750082949 1 0 0 0.0736027 0 GeneID:150356,Genbank:XM_011529933.2,HGNC:HGNC:25165,MIM:616236 chondroadherin like GO:0005518,GO:0005578,GO:0031012,GO:0032331,GO:0098633,GO:1904027 collagen binding|proteinaceous extracellular matrix|extracellular matrix|negative regulation of chondrocyte differentiation|collagen fibril binding|negative regulation of collagen fibril organization CHAF1A 3051.0689693885 2963.68824958558 3138.44968919142 1.05896755153997 0.0826583835232842 0.561311653430039 1 20.2389 21.9562 23.1639 22.4627 GeneID:10036,Genbank:XM_011527605.2,HGNC:HGNC:1910,MIM:601246 chromatin assembly factor 1 subunit A GO:0000790,GO:0003682,GO:0006260,GO:0006281,GO:0006335,GO:0006461,GO:0007049,GO:0031497,GO:0033186,GO:0042802,GO:0043234,GO:0051082,GO:0070087 nuclear chromatin|chromatin binding|DNA replication|DNA repair|DNA replication-dependent nucleosome assembly|protein complex assembly|cell cycle|chromatin assembly|CAF-1 complex|identical protein binding|protein complex|unfolded protein binding|chromo shadow domain binding CHAF1B 703.339312741483 655.039755617357 751.638869865609 1.1474706129206 0.198457206243347 0.21371296153844 1 5.66163 5.32349 6.47378 6.42351 GeneID:8208,Genbank:XM_017028477.1,HGNC:HGNC:1911,MIM:601245 chromatin assembly factor 1 subunit B GO:0000790,GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006281,GO:0006335,GO:0006351,GO:0006355,GO:0006461,GO:0007049,GO:0031497,GO:0033186,GO:0042393,GO:0043234,GO:0051082 nuclear chromatin|chromatin binding|nucleus|nucleoplasm|cytoplasm|DNA replication|DNA repair|DNA replication-dependent nucleosome assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|protein complex assembly|cell cycle|chromatin assembly|CAF-1 complex|histone binding|protein complex|unfolded protein binding CHAMP1 626.717771490674 704.266392875448 549.1691501059 0.779774749528653 -0.358870656386232 0.168692552678891 1 7.98957 6.88778 7.05774 4.72721 GeneID:283489,Genbank:NM_032436.3,HGNC:HGNC:20311,MIM:616327 chromosome alignment maintaining phosphoprotein 1 GO:0000777,GO:0000793,GO:0003676,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0031134,GO:0034501,GO:0035372,GO:0046872,GO:0051315,GO:0090543 condensed chromosome kinetochore|condensed chromosome|nucleic acid binding|nucleus|nucleoplasm|cytoplasm|spindle|sister chromatid biorientation|protein localization to kinetochore|protein localization to microtubule|metal ion binding|attachment of mitotic spindle microtubules to kinetochore|Flemming body CHAT 4.21883052278922 5.04479284362845 3.39286820195 0.672548567823786 -0.572289639815162 0.75085213242221 1 0.0345536 0.0596553 0.0159566 0.0446776 GeneID:1103,Genbank:NM_020984.3,HGNC:HGNC:1912,MIM:118490 choline O-acetyltransferase hsa00564,hsa04725 Glycerophospholipid metabolism|Cholinergic synapse CHCHD1 860.294187440733 878.826847520784 841.761527360682 0.957824092123875 -0.0621673707871303 0.674781502954984 1 45.0311 53.9303 46.9428 48.7565 GeneID:118487,Genbank:NM_203298.2,HGNC:HGNC:23518,MIM:608842 coiled-coil-helix-coiled-coil-helix domain containing 1 GO:0001650,GO:0003723,GO:0005654,GO:0005739,GO:0005743,GO:0005761,GO:0005829,GO:0070125,GO:0070126 fibrillar center|RNA binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|cytosol|mitochondrial translational elongation|mitochondrial translational termination CHCHD2 10578.9012111384 11130.8894900403 10026.9129322366 0.900818657952581 -0.150691385745312 0.392249763278161 1 390.36 403.896 340.28 399.989 GeneID:51142,Genbank:NM_016139.3,HGNC:HGNC:21645,MIM:616244 coiled-coil-helix-coiled-coil-helix domain containing 2 GO:0005634,GO:0005739,GO:0005758,GO:0006351,GO:0007005,GO:0008134,GO:0043565,GO:0045944,GO:1900037 nucleus|mitochondrion|mitochondrial intermembrane space|transcription, DNA-templated|mitochondrion organization|transcription factor binding|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|regulation of cellular response to hypoxia CHCHD3 3868.89490303612 3836.62036362435 3901.16944244789 1.01682446338333 0.0240706451105657 0.854662526429159 1 46.2341 46.8243 46.9103 47.1551 GeneID:54927,Genbank:NM_017812.3,HGNC:HGNC:21906,MIM:613748 coiled-coil-helix-coiled-coil-helix domain containing 3 GO:0000122,GO:0001227,GO:0005634,GO:0005737,GO:0005739,GO:0005743,GO:0006351,GO:0007007,GO:0008053,GO:0019902,GO:0032947,GO:0042407,GO:0061617,GO:0070062 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|cytoplasm|mitochondrion|mitochondrial inner membrane|transcription, DNA-templated|inner mitochondrial membrane organization|mitochondrial fusion|phosphatase binding|protein complex scaffold activity|cristae formation|MICOS complex|extracellular exosome CHCHD4 515.86109069589 567.473913148717 464.248268243063 0.818096228718444 -0.289657544471323 0.0893808495588157 0.978485089907035 10.9383 13.3215 10.0024 10.4604 GeneID:131474,Genbank:NM_001098502.1,HGNC:HGNC:26467,MIM:611077 coiled-coil-helix-coiled-coil-helix domain containing 4 GO:0005739,GO:0005758,GO:0015035,GO:0022417,GO:0045041,GO:0051084 mitochondrion|mitochondrial intermembrane space|protein disulfide oxidoreductase activity|protein maturation by protein folding|protein import into mitochondrial intermembrane space|'de novo' posttranslational protein folding CHCHD5 330.051538469755 332.031985803646 328.071091135864 0.988070743671893 -0.0173137556170485 0.92174428707616 1 1.15751 1.32076 1.08003 1.54337 GeneID:84269,Genbank:NM_032309.3,HGNC:HGNC:17840,MIM:616978 coiled-coil-helix-coiled-coil-helix domain containing 5 GO:0005758,GO:0009060 mitochondrial intermembrane space|aerobic respiration CHCHD6 113.382036619491 120.151703372106 106.612369866877 0.887314676985488 -0.172482262720944 0.554288013734459 1 0.169662 0.0984498 0.114987 0.107226 GeneID:84303,Genbank:NM_032343.2,HGNC:HGNC:28184,MIM:615634 coiled-coil-helix-coiled-coil-helix domain containing 6 GO:0005739,GO:0005743,GO:0005829,GO:0006974,GO:0042407,GO:0061617 mitochondrion|mitochondrial inner membrane|cytosol|cellular response to DNA damage stimulus|cristae formation|MICOS complex CHCHD7 586.16643359902 600.950621959271 571.382245238769 0.950797327367596 -0.0727902469277276 0.677506301466694 1 9.19344 8.58902 8.5558 8.48814 GeneID:79145,Genbank:NM_001011667.2,HGNC:HGNC:28314,MIM:611238 coiled-coil-helix-coiled-coil-helix domain containing 7 GO:0005758 mitochondrial intermembrane space CHD1 261.122416867615 278.902360638403 243.342473096828 0.87250058601089 -0.19677199458545 0.659496444544997 1 1.12019 0.891141 1.19001 0.606769 GeneID:1105,Genbank:XM_005271867.5,HGNC:HGNC:1915,MIM:602118 chromodomain helicase DNA binding protein 1 GO:0001650,GO:0003677,GO:0004003,GO:0005524,GO:0005634,GO:0005737,GO:0006338,GO:0006351,GO:0006357,GO:0016569,GO:0035064,GO:0043923 fibrillar center|DNA binding|ATP-dependent DNA helicase activity|ATP binding|nucleus|cytoplasm|chromatin remodeling|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|covalent chromatin modification|methylated histone binding|positive regulation by host of viral transcription CHD1L 1440.39283483065 1486.00228487974 1394.78338478157 0.938614562691909 -0.0913952508003084 0.544506688721604 1 9.00132 8.48106 8.69096 8.06719 GeneID:9557,Genbank:NM_001348451.1,HGNC:HGNC:1916,MIM:613039 chromodomain helicase DNA binding protein 1 like GO:0000166,GO:0000717,GO:0004003,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006281,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006338,GO:0006974,GO:0016887,GO:0033683,GO:0070911 nucleotide binding|nucleotide-excision repair, DNA duplex unwinding|ATP-dependent DNA helicase activity|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|DNA repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|chromatin remodeling|cellular response to DNA damage stimulus|ATPase activity|nucleotide-excision repair, DNA incision|global genome nucleotide-excision repair CHD2 1445.25989747151 1470.42586122158 1420.09393372144 0.965770509872344 -0.050247683882991 0.758420709522965 1 4.45487 4.16809 4.73008 3.76498 GeneID:1106,Genbank:NM_001271.3,HGNC:HGNC:1917,MIM:602119 chromodomain helicase DNA binding protein 2 GO:0001046,GO:0003677,GO:0003723,GO:0004003,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0006357,GO:0006974,GO:0007517,GO:0016569,GO:0042393,GO:0043231,GO:0060218,GO:0070062 core promoter sequence-specific DNA binding|DNA binding|RNA binding|ATP-dependent DNA helicase activity|ATP binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|cellular response to DNA damage stimulus|muscle organ development|covalent chromatin modification|histone binding|intracellular membrane-bounded organelle|hematopoietic stem cell differentiation|extracellular exosome CHD3 6357.50042453939 6133.8030762471 6581.19777283167 1.07293920118125 0.101568327129438 0.441985221055811 1 18.7336 18.5278 20.853 20.1072 GeneID:1107,Genbank:XM_005256427.4,HGNC:HGNC:1918,MIM:602120 chromodomain helicase DNA binding protein 3 GO:0003677,GO:0003723,GO:0004003,GO:0004386,GO:0004407,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005815,GO:0006333,GO:0006351,GO:0006355,GO:0006357,GO:0007051,GO:0007098,GO:0008270,GO:0016581,GO:1901796 DNA binding|RNA binding|ATP-dependent DNA helicase activity|helicase activity|histone deacetylase activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|microtubule organizing center|chromatin assembly or disassembly|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|spindle organization|centrosome cycle|zinc ion binding|NuRD complex|regulation of signal transduction by p53 class mediator CHD4 9551.98740456369 9546.51203853177 9557.46277059562 1.00114709246892 0.0016539561772696 0.994985807385668 1 34.9226 35.834 37.1339 34.0911 GeneID:1108,Genbank:XM_017018731.1,HGNC:HGNC:1919,MIM:603277 chromodomain helicase DNA binding protein 4 GO:0000122,GO:0000790,GO:0001103,GO:0003677,GO:0004003,GO:0004407,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006351,GO:0006357,GO:0008270,GO:0016020,GO:0016581,GO:0032993,GO:0042826,GO:0043044,GO:0043234,GO:0072553,GO:1901796 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II repressing transcription factor binding|DNA binding|ATP-dependent DNA helicase activity|histone deacetylase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|zinc ion binding|membrane|NuRD complex|protein-DNA complex|histone deacetylase binding|ATP-dependent chromatin remodeling|protein complex|terminal button organization|regulation of signal transduction by p53 class mediator hsa05165,hsa05203 Human papillomavirus infection|Viral carcinogenesis CHD5 7.39111114712971 4.60274771635603 10.1794745779034 2.21160819693208 1.14509582390467 0.312032740350996 1 0.015706 0.0172884 0.0402805 0.0205001 GeneID:26038,Genbank:NM_015557.2,HGNC:HGNC:16816,MIM:610771 chromodomain helicase DNA binding protein 5 CHD6 644.431915473368 665.53316881231 623.330662134426 0.936588424656285 -0.0945128870811876 0.694871606263215 1 1.44811 1.38724 1.65855 1.08181 GeneID:84181,Genbank:NM_032221.4,HGNC:HGNC:19057,MIM:616114 chromodomain helicase DNA binding protein 6 GO:0001221,GO:0003677,GO:0004386,GO:0005524,GO:0005654,GO:0006351,GO:0008094,GO:0016032,GO:0016569,GO:0036091 transcription cofactor binding|DNA binding|helicase activity|ATP binding|nucleoplasm|transcription, DNA-templated|DNA-dependent ATPase activity|viral process|covalent chromatin modification|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress CHD7 228.461691296651 238.333312481275 218.590070112027 0.917161213580671 -0.12475274973534 0.589088893275294 1 0.636567 0.528756 0.624673 0.465452 GeneID:55636,Genbank:XM_011517553.2,HGNC:HGNC:20626,MIM:608892 chromodomain helicase DNA binding protein 7 CHD8 1565.72845020109 1564.98021583402 1566.47668456815 1.00095622214197 0.00137887779048423 0.993480292081036 1 5.24674 5.15624 5.97332 4.53191 GeneID:57680,Genbank:NM_020920.3,HGNC:HGNC:20153,MIM:610528 chromodomain helicase DNA binding protein 8 GO:0000122,GO:0001701,GO:0002039,GO:0003677,GO:0003678,GO:0003682,GO:0005524,GO:0005634,GO:0005654,GO:0006351,GO:0007420,GO:0008013,GO:0008094,GO:0016569,GO:0030178,GO:0035064,GO:0042393,GO:0043044,GO:0043234,GO:0045892,GO:0045893,GO:0045944,GO:0045945,GO:0048565,GO:0060070,GO:0070016,GO:0071339,GO:0090090,GO:2000270 negative regulation of transcription from RNA polymerase II promoter|in utero embryonic development|p53 binding|DNA binding|DNA helicase activity|chromatin binding|ATP binding|nucleus|nucleoplasm|transcription, DNA-templated|brain development|beta-catenin binding|DNA-dependent ATPase activity|covalent chromatin modification|negative regulation of Wnt signaling pathway|methylated histone binding|histone binding|ATP-dependent chromatin remodeling|protein complex|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|digestive tract development|canonical Wnt signaling pathway|armadillo repeat domain binding|MLL1 complex|negative regulation of canonical Wnt signaling pathway|negative regulation of fibroblast apoptotic process hsa04310 Wnt signaling pathway CHD9 260.794078641312 233.163041122953 288.425116159672 1.23701044029349 0.306857676624773 0.531801873049521 1 0.682556 0.479047 0.928088 0.517628 GeneID:80205,Genbank:XM_005256168.4,HGNC:HGNC:25701,MIM:616936 chromodomain helicase DNA binding protein 9 GO:0003677,GO:0004386,GO:0005524,GO:0005654,GO:0005737,GO:0006351,GO:0006355,GO:0016569,GO:0019216 DNA binding|helicase activity|ATP binding|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|covalent chromatin modification|regulation of lipid metabolic process CHDH 762.537324810412 699.69408812527 825.380561495553 1.17963060643694 0.238335159846941 0.139662966064424 1 2.98117 3.17439 4.12286 3.3648 GeneID:55349,Genbank:XM_017006799.2,HGNC:HGNC:24288 choline dehydrogenase GO:0005743,GO:0008812,GO:0019285,GO:0042426,GO:0050660 mitochondrial inner membrane|choline dehydrogenase activity|glycine betaine biosynthetic process from choline|choline catabolic process|flavin adenine dinucleotide binding hsa00260 Glycine, serine and threonine metabolism CHEK1 899.823535305548 946.674164051544 852.972906559551 0.901020582318447 -0.150368032500496 0.350673551761629 1 8.01648 7.16631 7.59193 6.43839 GeneID:1111,Genbank:XM_011542560.2,HGNC:HGNC:1925,MIM:603078 checkpoint kinase 1 hsa04110,hsa04115,hsa04218,hsa05166,hsa05170,hsa05203 Cell cycle|p53 signaling pathway|Cellular senescence|Human T-cell leukemia virus 1 infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis CHEK2 289.182680176569 288.560726854351 289.804633498788 1.00431072744374 0.00620569915594381 1 1 2.05708 2.43541 2.26949 2.31112 GeneID:11200,Genbank:XM_011529845.2,HGNC:HGNC:16627,MIM:604373 checkpoint kinase 2 hsa04110,hsa04115,hsa04218,hsa05166 Cell cycle|p53 signaling pathway|Cellular senescence|Human T-cell leukemia virus 1 infection CHERP 1781.90387874176 1802.11388844903 1761.69386903449 0.977570774148283 -0.0327269404811374 0.808247346903491 1 16.3668 15.9423 16.7942 14.9922 GeneID:10523,Genbank:NM_006387.5,HGNC:HGNC:16930 calcium homeostasis endoplasmic reticulum protein GO:0000398,GO:0003723,GO:0005654,GO:0005737,GO:0006874,GO:0007399,GO:0008285,GO:0016020,GO:0033017,GO:0044325,GO:0048471,GO:0051209,GO:0051533 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|cytoplasm|cellular calcium ion homeostasis|nervous system development|negative regulation of cell proliferation|membrane|sarcoplasmic reticulum membrane|ion channel binding|perinuclear region of cytoplasm|release of sequestered calcium ion into cytosol|positive regulation of NFAT protein import into nucleus hsa03040 Spliceosome CHFR 431.006559949737 368.652053780647 493.361066118827 1.33828378564353 0.420384074670549 0.0209843984423074 0.592744489333324 3.64833 3.68028 5.36785 4.62702 GeneID:55743,Genbank:NM_001161347.1,HGNC:HGNC:20455,MIM:605209 checkpoint with forkhead and ring finger domains GO:0000166,GO:0000209,GO:0004842,GO:0005634,GO:0007093,GO:0016605,GO:0019941,GO:0046872,GO:0051301 nucleotide binding|protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|mitotic cell cycle checkpoint|PML body|modification-dependent protein catabolic process|metal ion binding|cell division CHGB 146.925138667203 142.665561896821 151.184715437586 1.05971415545208 0.0836751684443343 0.742116646628867 1 1.34685 1.15413 1.16076 1.46777 GeneID:1114,Genbank:NM_001819.2,HGNC:HGNC:1930,MIM:118920 chromogranin B GO:0005179,GO:0005576,GO:0005788,GO:0030141,GO:0043687,GO:0044267 hormone activity|extracellular region|endoplasmic reticulum lumen|secretory granule|post-translational protein modification|cellular protein metabolic process CHI3L1 2.6951519568353 1.02816907859967 4.36213483507094 4.24262402542978 2.08495683496113 0.348083628734939 1 0.0242906 0.0214901 0.0895233 0.0833066 GeneID:1116,Genbank:NM_001276.2,HGNC:HGNC:1932,MIM:601525 chitinase 3 like 1 GO:0005201,GO:0005576,GO:0005578,GO:0005615,GO:0005737,GO:0005783,GO:0005975,GO:0006915,GO:0006954,GO:0007250,GO:0008061,GO:0009612,GO:0010800,GO:0030246,GO:0030324,GO:0034612,GO:0035580,GO:0043312,GO:0045766,GO:0048471,GO:0051216,GO:0051897,GO:0070062,GO:0070374,GO:0070555,GO:0070741,GO:0071347,GO:0071356,GO:0072606 extracellular matrix structural constituent|extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|endoplasmic reticulum|carbohydrate metabolic process|apoptotic process|inflammatory response|activation of NF-kappaB-inducing kinase activity|chitin binding|response to mechanical stimulus|positive regulation of peptidyl-threonine phosphorylation|carbohydrate binding|lung development|response to tumor necrosis factor|specific granule lumen|neutrophil degranulation|positive regulation of angiogenesis|perinuclear region of cytoplasm|cartilage development|positive regulation of protein kinase B signaling|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|response to interleukin-1|response to interleukin-6|cellular response to interleukin-1|cellular response to tumor necrosis factor|interleukin-8 secretion CHI3L2 5.40205005651779 4.01662376502878 6.78747634800679 1.68984618552098 0.756891934386093 0.619894975008915 1 0.0419491 0.07796 0.119885 0.0744511 GeneID:1117,Genbank:XM_024452754.1,HGNC:HGNC:1933,MIM:601526 chitinase 3 like 2 GO:0005615,GO:0005737,GO:0005975,GO:0008061,GO:0016787,GO:0030246 extracellular space|cytoplasm|carbohydrate metabolic process|chitin binding|hydrolase activity|carbohydrate binding CHIC1 129.968618082558 146.508680872471 113.428555292645 0.77421047419968 -0.369202269078738 0.522702895416928 1 0.664612 0.363829 0.536191 0.305518 GeneID:53344,Genbank:XM_017029582.1,HGNC:HGNC:1934,MIM:300922 cysteine rich hydrophobic domain 1 GO:0005622,GO:0005886,GO:0031410 intracellular|plasma membrane|cytoplasmic vesicle CHIC2 904.428122916441 992.270421743795 816.585824089086 0.822946856214897 -0.281128826756564 0.0702357343589437 0.92021045003939 2.34577 2.5419 1.98574 1.92281 GeneID:26511,Genbank:XM_006714037.4,HGNC:HGNC:1935,MIM:604332 cysteine rich hydrophobic domain 2 CHID1 1442.0204784791 1364.67157595243 1519.36938100577 1.11335899990837 0.154918861212029 0.30238447568011 1 7.46214 8.10486 10.0039 8.34191 GeneID:66005,Genbank:NM_001142675.1,HGNC:HGNC:28474,MIM:615692 chitinase domain containing 1 GO:0002576,GO:0004568,GO:0005576,GO:0005615,GO:0005634,GO:0005764,GO:0005770,GO:0005802,GO:0005975,GO:0006032,GO:0008061,GO:0016020,GO:0043202,GO:0045087,GO:0070062,GO:0070492,GO:1900016 platelet degranulation|chitinase activity|extracellular region|extracellular space|nucleus|lysosome|late endosome|trans-Golgi network|carbohydrate metabolic process|chitin catabolic process|chitin binding|membrane|lysosomal lumen|innate immune response|extracellular exosome|oligosaccharide binding|negative regulation of cytokine production involved in inflammatory response CHIT1 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0 0.0372141 0 GeneID:1118,Genbank:NM_001256125.1,HGNC:HGNC:1936,MIM:600031 chitinase 1 GO:0000272,GO:0004553,GO:0004568,GO:0005576,GO:0005615,GO:0005764,GO:0006032,GO:0006955,GO:0008061,GO:0008843,GO:0009617,GO:0035580,GO:0043312,GO:0044245,GO:1904724 polysaccharide catabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|chitinase activity|extracellular region|extracellular space|lysosome|chitin catabolic process|immune response|chitin binding|endochitinase activity|response to bacterium|specific granule lumen|neutrophil degranulation|polysaccharide digestion|tertiary granule lumen hsa00520 Amino sugar and nucleotide sugar metabolism CHKA 448.943035998992 439.951521437034 457.934550560949 1.04087502428717 0.0577968576239416 0.768731453632628 1 3.48043 4.23353 3.7945 4.42923 GeneID:1119,Genbank:NM_212469.1,HGNC:HGNC:1937,MIM:118491 choline kinase alpha hsa00564,hsa05231 Glycerophospholipid metabolism|Choline metabolism in cancer CHKB 235.336646237877 230.771536043814 239.901756431941 1.03956389312412 0.0559784310780087 0.817957281742078 1 4.21404 4.64361 4.76778 4.04632 GeneID:1120,Genbank:NM_005198.4,HGNC:HGNC:1938,MIM:612395 choline kinase beta GO:0004103,GO:0004305,GO:0005524,GO:0005829,GO:0006646,GO:0006656 choline kinase activity|ethanolamine kinase activity|ATP binding|cytosol|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process hsa00564,hsa05231 Glycerophospholipid metabolism|Choline metabolism in cancer CHM 305.783421391447 310.563879666037 301.002963116856 0.969214331816493 -0.0451123567430591 0.936560416100396 1 1.41 0.995264 1.48266 0.937851 GeneID:1121,Genbank:NM_000390.3,HGNC:HGNC:1940,MIM:300390 CHM, Rab escort protein 1 CHML 125.419022193105 124.322214616298 126.515829769912 1.01764459521884 0.0252337988985739 0.965398813609172 1 0.614999 0.726567 0.884843 0.510509 GeneID:1122,Genbank:NM_001821.3,HGNC:HGNC:1941,MIM:118825 CHM like, Rab escort protein 2 GO:0005092,GO:0005096,GO:0005634,GO:0005654,GO:0005829,GO:0005968,GO:0006886,GO:0007264,GO:0017137,GO:0018344,GO:0043687 GDP-dissociation inhibitor activity|GTPase activator activity|nucleus|nucleoplasm|cytosol|Rab-protein geranylgeranyltransferase complex|intracellular protein transport|small GTPase mediated signal transduction|Rab GTPase binding|protein geranylgeranylation|post-translational protein modification CHMP1A 2510.94426699893 2413.63639284412 2608.25214115373 1.08063175915254 0.111874987687436 0.434806972360067 1 33.7733 34.5016 38.6171 37.3321 GeneID:5119,Genbank:NM_001083314.3,HGNC:HGNC:8740,MIM:164010 charged multivesicular body protein 1A GO:0000794,GO:0000815,GO:0000920,GO:0005769,GO:0005815,GO:0006351,GO:0006997,GO:0007034,GO:0007076,GO:0007080,GO:0010824,GO:0015031,GO:0016192,GO:0016363,GO:0016458,GO:0019904,GO:0042803,GO:0045014,GO:0045786,GO:1901673 condensed nuclear chromosome|ESCRT III complex|cell separation after cytokinesis|early endosome|microtubule organizing center|transcription, DNA-templated|nucleus organization|vacuolar transport|mitotic chromosome condensation|mitotic metaphase plate congression|regulation of centrosome duplication|protein transport|vesicle-mediated transport|nuclear matrix|gene silencing|protein domain specific binding|protein homodimerization activity|negative regulation of transcription by glucose|negative regulation of cell cycle|regulation of mitotic spindle assembly hsa04144,hsa04217 Endocytosis|Necroptosis CHMP1B 1477.20685533602 1480.17047133179 1474.24323934026 0.995995574762282 -0.00578876251638958 0.975110480194259 1 24.0067 24.1707 24.8668 23.5657 GeneID:57132,Genbank:NM_020412.4,HGNC:HGNC:24287,MIM:606486 charged multivesicular body protein 1B GO:0000815,GO:0000920,GO:0005634,GO:0005829,GO:0006997,GO:0007034,GO:0007080,GO:0010008,GO:0010824,GO:0015031,GO:0019904,GO:0030117,GO:0030496,GO:0031902,GO:0036258,GO:0039702,GO:0042802,GO:0045184,GO:0051301,GO:0070062,GO:1901673,GO:1904903 ESCRT III complex|cell separation after cytokinesis|nucleus|cytosol|nucleus organization|vacuolar transport|mitotic metaphase plate congression|endosome membrane|regulation of centrosome duplication|protein transport|protein domain specific binding|membrane coat|midbody|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|establishment of protein localization|cell division|extracellular exosome|regulation of mitotic spindle assembly|ESCRT III complex disassembly hsa04144,hsa04217 Endocytosis|Necroptosis CHMP2A 3084.82686500437 2842.98660588001 3326.66712412873 1.17013112803569 0.226670211147594 0.202101334205546 1 37.9844 35.1035 41.7599 47.8251 GeneID:27243,Genbank:XM_005258747.3,HGNC:HGNC:30216,MIM:610893 charged multivesicular body protein 2A GO:0000815,GO:0000920,GO:0005635,GO:0005829,GO:0006997,GO:0007034,GO:0007080,GO:0010324,GO:0010458,GO:0010824,GO:0015031,GO:0016020,GO:0016197,GO:0016236,GO:0019058,GO:0019904,GO:0030117,GO:0031210,GO:0031468,GO:0031902,GO:0036258,GO:0039702,GO:0045184,GO:0050792,GO:0051258,GO:0051260,GO:0051291,GO:0060548,GO:0070062,GO:1901673,GO:1902188,GO:1903543,GO:1903723,GO:1904903 ESCRT III complex|cell separation after cytokinesis|nuclear envelope|cytosol|nucleus organization|vacuolar transport|mitotic metaphase plate congression|membrane invagination|exit from mitosis|regulation of centrosome duplication|protein transport|membrane|endosomal transport|macroautophagy|viral life cycle|protein domain specific binding|membrane coat|phosphatidylcholine binding|nuclear envelope reassembly|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|establishment of protein localization|regulation of viral process|protein polymerization|protein homooligomerization|protein heterooligomerization|negative regulation of cell death|extracellular exosome|regulation of mitotic spindle assembly|positive regulation of viral release from host cell|positive regulation of exosomal secretion|negative regulation of centriole elongation|ESCRT III complex disassembly hsa04144,hsa04217 Endocytosis|Necroptosis CHMP2B 1034.39872680154 1099.95760065716 968.839852945933 0.880797452890104 -0.183117797997035 0.260187691164288 1 15.7951 14.0953 14.7761 11.7572 GeneID:25978,Genbank:NM_014043.3,HGNC:HGNC:24537,MIM:609512 charged multivesicular body protein 2B GO:0000815,GO:0000920,GO:0005622,GO:0005737,GO:0005764,GO:0005829,GO:0005886,GO:0006997,GO:0007032,GO:0007034,GO:0007080,GO:0010824,GO:0015031,GO:0019904,GO:0031902,GO:0039702,GO:0045296,GO:0050890,GO:0070050,GO:1901673,GO:1902188 ESCRT III complex|cell separation after cytokinesis|intracellular|cytoplasm|lysosome|cytosol|plasma membrane|nucleus organization|endosome organization|vacuolar transport|mitotic metaphase plate congression|regulation of centrosome duplication|protein transport|protein domain specific binding|late endosome membrane|viral budding via host ESCRT complex|cadherin binding|cognition|neuron cellular homeostasis|regulation of mitotic spindle assembly|positive regulation of viral release from host cell hsa04144,hsa04217 Endocytosis|Necroptosis CHMP3 13.1673988180255 11.3098598645963 15.0249377714547 1.3284813385255 0.40977796211083 0.632784206954919 1 28.1362 29.6068 34.93 32.5977 GeneID:51652,Genbank:NM_001005753.2,HGNC:HGNC:29865,MIM:610052 charged multivesicular body protein 3 GO:0000815,GO:0000920,GO:0005622,GO:0005770,GO:0005829,GO:0005886,GO:0006915,GO:0007049,GO:0010824,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0031210,GO:0031410,GO:0031902,GO:0036258,GO:0039702,GO:0042802,GO:0042803,GO:0050792,GO:0051258,GO:0051291,GO:0061763,GO:0070062,GO:0071985,GO:0097352,GO:1902187,GO:1902188,GO:1990381,GO:2000641 ESCRT III complex|cell separation after cytokinesis|intracellular|late endosome|cytosol|plasma membrane|apoptotic process|cell cycle|regulation of centrosome duplication|protein transport|endosomal transport|macroautophagy|viral life cycle|phosphatidylcholine binding|cytoplasmic vesicle|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|regulation of viral process|protein polymerization|protein heterooligomerization|multivesicular body-lysosome fusion|extracellular exosome|multivesicular body sorting pathway|autophagosome maturation|negative regulation of viral release from host cell|positive regulation of viral release from host cell|ubiquitin-specific protease binding|regulation of early endosome to late endosome transport hsa04144,hsa04217 Endocytosis|Necroptosis CHMP4A 771.028012055841 740.531676620293 801.524347491389 1.08236335162523 0.114184896197551 0.464953557752832 1 16.5147 15.5987 16.5369 17.9029 GeneID:29082,Genbank:NM_014169.3,HGNC:HGNC:20274,MIM:610051 charged multivesicular body protein 4A GO:0000815,GO:0000920,GO:0005634,GO:0005737,GO:0005829,GO:0006620,GO:0006900,GO:0006997,GO:0007034,GO:0007080,GO:0008289,GO:0009898,GO:0010324,GO:0016197,GO:0016236,GO:0019058,GO:0030117,GO:0030496,GO:0030659,GO:0031902,GO:0036258,GO:0039702,GO:0042802,GO:0042803,GO:0051117,GO:0051258,GO:0051260,GO:0070062,GO:0097320,GO:1901215,GO:1902902 ESCRT III complex|cell separation after cytokinesis|nucleus|cytoplasm|cytosol|posttranslational protein targeting to endoplasmic reticulum membrane|vesicle budding from membrane|nucleus organization|vacuolar transport|mitotic metaphase plate congression|lipid binding|cytoplasmic side of plasma membrane|membrane invagination|endosomal transport|macroautophagy|viral life cycle|membrane coat|midbody|cytoplasmic vesicle membrane|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|ATPase binding|protein polymerization|protein homooligomerization|extracellular exosome|plasma membrane tubulation|negative regulation of neuron death|negative regulation of autophagosome assembly hsa04144,hsa04217 Endocytosis|Necroptosis CHMP4B 3295.54574952377 3336.06571848058 3255.02578056696 0.9757079312123 -0.0354787393648571 0.794476359139582 1 85.2523 84.0302 79.0933 87.0955 GeneID:128866,Genbank:NM_176812.4,HGNC:HGNC:16171,MIM:610897 charged multivesicular body protein 4B GO:0000281,GO:0000815,GO:0000920,GO:0005634,GO:0005635,GO:0005737,GO:0005768,GO:0005829,GO:0006620,GO:0006914,GO:0006997,GO:0007034,GO:0007080,GO:0009898,GO:0010458,GO:0010824,GO:0016197,GO:0016236,GO:0019058,GO:0030117,GO:0030496,GO:0031468,GO:0031902,GO:0031982,GO:0036258,GO:0036438,GO:0039702,GO:0042802,GO:0042803,GO:0045296,GO:0046755,GO:0050792,GO:0051260,GO:0060548,GO:0070062,GO:0090148,GO:0090611,GO:1901215,GO:1901673,GO:1902188,GO:1902902 mitotic cytokinesis|ESCRT III complex|cell separation after cytokinesis|nucleus|nuclear envelope|cytoplasm|endosome|cytosol|posttranslational protein targeting to endoplasmic reticulum membrane|autophagy|nucleus organization|vacuolar transport|mitotic metaphase plate congression|cytoplasmic side of plasma membrane|exit from mitosis|regulation of centrosome duplication|endosomal transport|macroautophagy|viral life cycle|membrane coat|midbody|nuclear envelope reassembly|late endosome membrane|vesicle|multivesicular body assembly|maintenance of lens transparency|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|cadherin binding|viral budding|regulation of viral process|protein homooligomerization|negative regulation of cell death|extracellular exosome|membrane fission|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|negative regulation of neuron death|regulation of mitotic spindle assembly|positive regulation of viral release from host cell|negative regulation of autophagosome assembly hsa04144,hsa04217 Endocytosis|Necroptosis CHMP5 1773.45985116032 1874.4296825272 1672.49001979344 0.892266077188079 -0.164454103353274 0.253661069453816 1 37.7644 37.7137 34.9998 32.3398 GeneID:51510,Genbank:NM_016410.5,HGNC:HGNC:26942,MIM:610900 charged multivesicular body protein 5 GO:0000920,GO:0001919,GO:0005634,GO:0005829,GO:0006997,GO:0007040,GO:0007080,GO:0008333,GO:0010008,GO:0010824,GO:0015031,GO:0045296,GO:0046755,GO:0061763,GO:0071985,GO:1901673 cell separation after cytokinesis|regulation of receptor recycling|nucleus|cytosol|nucleus organization|lysosome organization|mitotic metaphase plate congression|endosome to lysosome transport|endosome membrane|regulation of centrosome duplication|protein transport|cadherin binding|viral budding|multivesicular body-lysosome fusion|multivesicular body sorting pathway|regulation of mitotic spindle assembly hsa04144,hsa04217 Endocytosis|Necroptosis CHMP6 691.721089494123 661.372466223226 722.06971276502 1.09177468014114 0.12667514436734 0.43241800530547 1 14.9022 14.1229 15.4907 15.9658 GeneID:79643,Genbank:NM_024591.4,HGNC:HGNC:25675,MIM:610901 charged multivesicular body protein 6 GO:0000815,GO:0000920,GO:0005829,GO:0006997,GO:0007034,GO:0007080,GO:0007175,GO:0010008,GO:0015031,GO:0016020,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0032403,GO:0036258,GO:0039702,GO:0047485,GO:0070062,GO:1904902 ESCRT III complex|cell separation after cytokinesis|cytosol|nucleus organization|vacuolar transport|mitotic metaphase plate congression|negative regulation of epidermal growth factor-activated receptor activity|endosome membrane|protein transport|membrane|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|protein complex binding|multivesicular body assembly|viral budding via host ESCRT complex|protein N-terminus binding|extracellular exosome|ESCRT III complex assembly hsa04144,hsa04217 Endocytosis|Necroptosis CHMP7 2258.5509768838 2288.74665458585 2228.35529918174 0.973613787579718 -0.0385784963385536 0.766086487382106 1 17.9997 19.3455 19.2215 18.0495 GeneID:91782,Genbank:NM_152272.4,HGNC:HGNC:28439,MIM:611130 charged multivesicular body protein 7 GO:0000815,GO:0000920,GO:0005634,GO:0005635,GO:0005829,GO:0006997,GO:0007080,GO:0008565,GO:0010458,GO:0016197,GO:0019058,GO:0031468,GO:0036258,GO:0039702,GO:0045324,GO:0071168,GO:1904903 ESCRT III complex|cell separation after cytokinesis|nucleus|nuclear envelope|cytosol|nucleus organization|mitotic metaphase plate congression|protein transporter activity|exit from mitosis|endosomal transport|viral life cycle|nuclear envelope reassembly|multivesicular body assembly|viral budding via host ESCRT complex|late endosome to vacuole transport|protein localization to chromatin|ESCRT III complex disassembly hsa04144,hsa04217 Endocytosis|Necroptosis CHN1 1190.24454298193 1053.98897542424 1326.50011053961 1.25855216844719 0.331765019121187 0.025110012682978 0.631315976879816 12.0759 11.8949 16.8089 14.1268 GeneID:1123,Genbank:NM_001025201.3,HGNC:HGNC:1943,MIM:118423 chimerin 1 GO:0005070,GO:0005096,GO:0005737,GO:0005829,GO:0008045,GO:0035556,GO:0043087,GO:0046872,GO:0046875,GO:0048013,GO:0050770,GO:0051056 SH3/SH2 adaptor activity|GTPase activator activity|cytoplasm|cytosol|motor neuron axon guidance|intracellular signal transduction|regulation of GTPase activity|metal ion binding|ephrin receptor binding|ephrin receptor signaling pathway|regulation of axonogenesis|regulation of small GTPase mediated signal transduction CHN2 31.6734140609214 33.7855007697342 29.5613273521087 0.874970821169251 -0.192693188635346 0.722226064806593 1 0.171277 0.217614 0.14687 0.172742 GeneID:1124,Genbank:NM_001293069.1,HGNC:HGNC:1944,MIM:602857 chimerin 2 GO:0005096,GO:0005737,GO:0016020,GO:0035556,GO:0043087,GO:0045202,GO:0046872 GTPase activator activity|cytoplasm|membrane|intracellular signal transduction|regulation of GTPase activity|synapse|metal ion binding CHODL 1.75490156042702 2.05633815719933 1.45346496365472 0.706821958521787 -0.500581234739772 0.969170192895383 1 0.0134515 0 0.0128396 0.0238956 GeneID:140578,Genbank:XM_011529457.2,HGNC:HGNC:17807,MIM:607247 chondrolectin CHORDC1 365.791234134051 424.316245848229 307.266222419873 0.724144374452675 -0.465650735227987 0.0152789456989805 0.512226950647688 3.76852 3.06362 2.58296 2.455 GeneID:26973,Genbank:NM_001144073.1,HGNC:HGNC:14525,MIM:604353 cysteine and histidine rich domain containing 1 GO:0005524,GO:0008270,GO:0010824,GO:0043531,GO:0051879,GO:0061077,GO:1900034,GO:2000299 ATP binding|zinc ion binding|regulation of centrosome duplication|ADP binding|Hsp90 protein binding|chaperone-mediated protein folding|regulation of cellular response to heat|negative regulation of Rho-dependent protein serine/threonine kinase activity CHP1 2893.22851122999 2778.27756351142 3008.17945894856 1.08274979377747 0.114699897627135 0.396061051263103 1 35.6272 34.4094 40.244 36.4441 GeneID:11261,Genbank:XM_017021879.2,HGNC:HGNC:17433,MIM:606988 calcineurin like EF-hand protein 1 GO:0000139,GO:0001578,GO:0001933,GO:0004860,GO:0005215,GO:0005509,GO:0005634,GO:0005737,GO:0005783,GO:0005793,GO:0005829,GO:0005886,GO:0005925,GO:0006469,GO:0006611,GO:0006813,GO:0007264,GO:0008017,GO:0010923,GO:0015459,GO:0015630,GO:0017156,GO:0019900,GO:0022406,GO:0030133,GO:0030214,GO:0031122,GO:0031397,GO:0031953,GO:0032088,GO:0032417,GO:0042308,GO:0048306,GO:0050821,GO:0051222,GO:0051259,GO:0051453,GO:0060050,GO:0061024,GO:0061025,GO:0070062,GO:0070885,GO:0071468,GO:0090314,GO:1901214 Golgi membrane|microtubule bundle formation|negative regulation of protein phosphorylation|protein kinase inhibitor activity|transporter activity|calcium ion binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|focal adhesion|negative regulation of protein kinase activity|protein export from nucleus|potassium ion transport|small GTPase mediated signal transduction|microtubule binding|negative regulation of phosphatase activity|potassium channel regulator activity|microtubule cytoskeleton|calcium ion regulated exocytosis|kinase binding|membrane docking|transport vesicle|hyaluronan catabolic process|cytoplasmic microtubule organization|negative regulation of protein ubiquitination|negative regulation of protein autophosphorylation|negative regulation of NF-kappaB transcription factor activity|positive regulation of sodium:proton antiporter activity|negative regulation of protein import into nucleus|calcium-dependent protein binding|protein stabilization|positive regulation of protein transport|protein oligomerization|regulation of intracellular pH|positive regulation of protein glycosylation|membrane organization|membrane fusion|extracellular exosome|negative regulation of calcineurin-NFAT signaling cascade|cellular response to acidic pH|positive regulation of protein targeting to membrane|regulation of neuron death CHPF 2362.47659586495 2275.69905717835 2449.25413455155 1.07626451170059 0.106032690181779 0.468947134047633 1 34.0307 36.1296 38.4406 39.1451 GeneID:79586,Genbank:NM_024536.5,HGNC:HGNC:24291,MIM:610405 chondroitin polymerizing factor GO:0000139,GO:0005759,GO:0005829,GO:0016021,GO:0030206,GO:0032580,GO:0046872,GO:0047238,GO:0050510 Golgi membrane|mitochondrial matrix|cytosol|integral component of membrane|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|metal ion binding|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHPF2 3420.99452534929 3245.06058454398 3596.92846615459 1.10843183738588 0.148520054924276 0.281446576391165 1 40.4996 42.0546 47.8496 45.8636 GeneID:54480,Genbank:NM_019015.2,HGNC:HGNC:29270,MIM:608037 chondroitin polymerizing factor 2 GO:0000139,GO:0008376,GO:0016020,GO:0016021,GO:0030206,GO:0032580,GO:0050510 Golgi membrane|acetylgalactosaminyltransferase activity|membrane|integral component of membrane|chondroitin sulfate biosynthetic process|Golgi cisterna membrane|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHPT1 1185.88853916907 1013.84235508417 1357.93472325396 1.33939435104901 0.421580788549617 0.00451851105169184 0.266060562514325 24.4018 23.3726 33.2099 32.969 GeneID:56994,Genbank:NM_020244.2,HGNC:HGNC:17852,MIM:616747 choline phosphotransferase 1 GO:0000139,GO:0001558,GO:0004142,GO:0006629,GO:0006656,GO:0006657,GO:0006663,GO:0016020,GO:0016021,GO:0019992,GO:0043231,GO:0046872 Golgi membrane|regulation of cell growth|diacylglycerol cholinephosphotransferase activity|lipid metabolic process|phosphatidylcholine biosynthetic process|CDP-choline pathway|platelet activating factor biosynthetic process|membrane|integral component of membrane|diacylglycerol binding|intracellular membrane-bounded organelle|metal ion binding hsa00440,hsa00564,hsa00565,hsa05231 Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Choline metabolism in cancer CHRAC1 853.132562643098 874.616084655306 831.64904063089 0.950873251957916 -0.0726750471332056 0.665292313021333 1 18.8824 16.8423 18.3409 16.0755 GeneID:54108,Genbank:NM_017444.5,HGNC:HGNC:13544,MIM:607268 chromatin accessibility complex 1 GO:0003677,GO:0003887,GO:0006338,GO:0008622,GO:0008623,GO:0046982 DNA binding|DNA-directed DNA polymerase activity|chromatin remodeling|epsilon DNA polymerase complex|CHRAC|protein heterodimerization activity CHRD 27.7845026137742 30.8548810130979 24.7141242144505 0.800979404326965 -0.320162947955448 0.543179647752141 1 0.172818 0.318799 0.159067 0.322223 GeneID:8646,Genbank:NM_001304473.1,HGNC:HGNC:1949,MIM:603475 chordin GO:0001501,GO:0001649,GO:0001702,GO:0001707,GO:0002053,GO:0005615,GO:0008201,GO:0019955,GO:0021919,GO:0030336,GO:0030514,GO:0030900,GO:0033504,GO:0045545,GO:0045668,GO:0045785 skeletal system development|osteoblast differentiation|gastrulation with mouth forming second|mesoderm formation|positive regulation of mesenchymal cell proliferation|extracellular space|heparin binding|cytokine binding|BMP signaling pathway involved in spinal cord dorsal/ventral patterning|negative regulation of cell migration|negative regulation of BMP signaling pathway|forebrain development|floor plate development|syndecan binding|negative regulation of osteoblast differentiation|positive regulation of cell adhesion hsa04350 TGF-beta signaling pathway CHRDL1 110.213699993317 136.582791319485 83.8446086671484 0.613873884529311 -0.703985798986621 0.0391035782347085 0.753859521009372 1.26809 0.885168 0.73478 0.667984 GeneID:91851,Genbank:NM_001143983.2,HGNC:HGNC:29861,MIM:300350 chordin like 1 GO:0001503,GO:0001654,GO:0005576,GO:0005788,GO:0007399,GO:0030154,GO:0030509,GO:0030514,GO:0043687,GO:0044267,GO:0048749 ossification|eye development|extracellular region|endoplasmic reticulum lumen|nervous system development|cell differentiation|BMP signaling pathway|negative regulation of BMP signaling pathway|post-translational protein modification|cellular protein metabolic process|compound eye development CHRFAM7A 3.97586138546894 5.04479284362845 2.90692992730943 0.576223844549112 -0.795298733415977 0.648569501490011 1 0.039948 0.0478436 0.0250467 0.0466096 GeneID:89832,Genbank:XM_011522153.2,HGNC:HGNC:15781,MIM:609756 CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion GO:0004888,GO:0005230,GO:0016021 transmembrane signaling receptor activity|extracellular ligand-gated ion channel activity|integral component of membrane CHRM1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0172861 0 0 0 GeneID:1128,Genbank:XM_011544742.2,HGNC:HGNC:1950,MIM:118510 cholinergic receptor muscarinic 1 GO:0003056,GO:0004435,GO:0005886,GO:0005887,GO:0006464,GO:0007165,GO:0007186,GO:0007197,GO:0007205,GO:0007207,GO:0007213,GO:0007271,GO:0007274,GO:0007399,GO:0008144,GO:0008283,GO:0008284,GO:0014069,GO:0016020,GO:0016907,GO:0030054,GO:0030425,GO:0040012,GO:0043270,GO:0043679,GO:0045202,GO:0045211,GO:0046541,GO:0050890,GO:0090316 regulation of vascular smooth muscle contraction|phosphatidylinositol phospholipase C activity|plasma membrane|integral component of plasma membrane|cellular protein modification process|signal transduction|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway|protein kinase C-activating G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway|G-protein coupled acetylcholine receptor signaling pathway|synaptic transmission, cholinergic|neuromuscular synaptic transmission|nervous system development|drug binding|cell proliferation|positive regulation of cell proliferation|postsynaptic density|membrane|G-protein coupled acetylcholine receptor activity|cell junction|dendrite|regulation of locomotion|positive regulation of ion transport|axon terminus|synapse|postsynaptic membrane|saliva secretion|cognition|positive regulation of intracellular protein transport hsa04020,hsa04024,hsa04080,hsa04151,hsa04725,hsa04810 Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Cholinergic synapse|Regulation of actin cytoskeleton CHRM2 1.2383154714421 0.538097676642304 1.93853326624189 3.60256761994999 1.84902550994227 0.680597935457111 1 0.00639238 0 0.00613427 0.0114254 GeneID:1129,Genbank:XM_024446648.1,HGNC:HGNC:1951,MIM:118493 cholinergic receptor muscarinic 2 GO:0005886,GO:0005887,GO:0006940,GO:0007186,GO:0007187,GO:0007188,GO:0007197,GO:0007207,GO:0007213,GO:0007271,GO:0007399,GO:0008016,GO:0008144,GO:0009615,GO:0016021,GO:0016907,GO:0030054,GO:0030425,GO:0030665,GO:0032279,GO:0032280,GO:0043025,GO:0043679,GO:0045202,GO:0045211,GO:0061024,GO:1990763 plasma membrane|integral component of plasma membrane|regulation of smooth muscle contraction|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway|phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway|G-protein coupled acetylcholine receptor signaling pathway|synaptic transmission, cholinergic|nervous system development|regulation of heart contraction|drug binding|response to virus|integral component of membrane|G-protein coupled acetylcholine receptor activity|cell junction|dendrite|clathrin-coated vesicle membrane|asymmetric synapse|symmetric synapse|neuronal cell body|axon terminus|synapse|postsynaptic membrane|membrane organization|arrestin family protein binding hsa04020,hsa04024,hsa04080,hsa04151,hsa04725,hsa04810 Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Cholinergic synapse|Regulation of actin cytoskeleton CHRM3 57.0196798456279 46.1715559876151 67.8678037036407 1.46990505847031 0.555722974042949 0.322512404610991 1 0.0836375 0.0822979 0.177402 0.0864853 GeneID:1131,Genbank:XM_017000153.1,HGNC:HGNC:1952,MIM:118494 cholinergic receptor muscarinic 3 GO:0003056,GO:0004435,GO:0004872,GO:0005886,GO:0005887,GO:0006464,GO:0006939,GO:0007165,GO:0007186,GO:0007197,GO:0007207,GO:0007213,GO:0007271,GO:0007399,GO:0008283,GO:0016323,GO:0016907,GO:0030054,GO:0030425,GO:0032279,GO:0042166,GO:0043679,GO:0045202,GO:0045211,GO:0045987,GO:0046541 regulation of vascular smooth muscle contraction|phosphatidylinositol phospholipase C activity|receptor activity|plasma membrane|integral component of plasma membrane|cellular protein modification process|smooth muscle contraction|signal transduction|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway|phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway|G-protein coupled acetylcholine receptor signaling pathway|synaptic transmission, cholinergic|nervous system development|cell proliferation|basolateral plasma membrane|G-protein coupled acetylcholine receptor activity|cell junction|dendrite|asymmetric synapse|acetylcholine binding|axon terminus|synapse|postsynaptic membrane|positive regulation of smooth muscle contraction|saliva secretion hsa04020,hsa04080,hsa04725,hsa04742,hsa04810,hsa04911,hsa04970,hsa04971,hsa04972 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Cholinergic synapse|Taste transduction|Regulation of actin cytoskeleton|Insulin secretion|Salivary secretion|Gastric acid secretion|Pancreatic secretion CHRM4 8.77124464687173 9.30154798208194 8.24094131166151 0.885975251381433 -0.174661695438845 0.928376823144402 1 0.279271 0.211229 0.257054 0.133128 GeneID:1132,Genbank:NM_000741.3,HGNC:HGNC:1953,MIM:118495 cholinergic receptor muscarinic 4 GO:0005886,GO:0005887,GO:0007165,GO:0007166,GO:0007186,GO:0007197,GO:0007207,GO:0007213,GO:0007271,GO:0008283,GO:0016907,GO:0030054,GO:0040012,GO:0045202,GO:0045211 plasma membrane|integral component of plasma membrane|signal transduction|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway|phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway|G-protein coupled acetylcholine receptor signaling pathway|synaptic transmission, cholinergic|cell proliferation|G-protein coupled acetylcholine receptor activity|cell junction|regulation of locomotion|synapse|postsynaptic membrane hsa04080,hsa04725,hsa04810 Neuroactive ligand-receptor interaction|Cholinergic synapse|Regulation of actin cytoskeleton CHRM5 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.00969388 0.00903415 GeneID:1133,Genbank:NM_001320917.1,HGNC:HGNC:1954,MIM:118496 cholinergic receptor muscarinic 5 GO:0001696,GO:0004435,GO:0005886,GO:0005887,GO:0007186,GO:0007197,GO:0007207,GO:0007213,GO:0007271,GO:0008283,GO:0015872,GO:0016907,GO:0019226,GO:0030054,GO:0045202,GO:0045211,GO:0060304 gastric acid secretion|phosphatidylinositol phospholipase C activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway|phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway|G-protein coupled acetylcholine receptor signaling pathway|synaptic transmission, cholinergic|cell proliferation|dopamine transport|G-protein coupled acetylcholine receptor activity|transmission of nerve impulse|cell junction|synapse|postsynaptic membrane|regulation of phosphatidylinositol dephosphorylation hsa04020,hsa04080,hsa04725,hsa04810 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Cholinergic synapse|Regulation of actin cytoskeleton CHRNA1 2.51239022307384 3.084507235799 1.94027321034868 0.62903830726339 -0.668780217661813 0.833661370103449 1 0.0543151 0.0164413 0.0171 0 GeneID:1134,Genbank:NM_000079.3,HGNC:HGNC:1955,MIM:100690 cholinergic receptor nicotinic alpha 1 subunit GO:0003009,GO:0005216,GO:0005886,GO:0005892,GO:0006810,GO:0007165,GO:0007271,GO:0007274,GO:0007528,GO:0009986,GO:0015276,GO:0015464,GO:0019228,GO:0022848,GO:0030054,GO:0031594,GO:0035094,GO:0042166,GO:0042391,GO:0045211,GO:0046716,GO:0048630,GO:0050881,GO:0050905,GO:0070050 skeletal muscle contraction|ion channel activity|plasma membrane|acetylcholine-gated channel complex|transport|signal transduction|synaptic transmission, cholinergic|neuromuscular synaptic transmission|neuromuscular junction development|cell surface|ligand-gated ion channel activity|acetylcholine receptor activity|neuronal action potential|acetylcholine-gated cation-selective channel activity|cell junction|neuromuscular junction|response to nicotine|acetylcholine binding|regulation of membrane potential|postsynaptic membrane|muscle cell cellular homeostasis|skeletal muscle tissue growth|musculoskeletal movement|neuromuscular process|neuron cellular homeostasis hsa04080 Neuroactive ligand-receptor interaction CHRNA10 16.9845116070755 18.4590171401091 15.5100060740419 0.840240081924007 -0.251126486623349 0.749752230126999 1 0.154857 0.175182 0.121957 0.147933 GeneID:57053,Genbank:XM_011520234.2,HGNC:HGNC:13800,MIM:606372 cholinergic receptor nicotinic alpha 10 subunit GO:0004888,GO:0005102,GO:0005262,GO:0005892,GO:0007204,GO:0007271,GO:0016020,GO:0022848,GO:0030054,GO:0030424,GO:0042127,GO:0042472,GO:0043204,GO:0045211,GO:0050910 transmembrane signaling receptor activity|receptor binding|calcium channel activity|acetylcholine-gated channel complex|positive regulation of cytosolic calcium ion concentration|synaptic transmission, cholinergic|membrane|acetylcholine-gated cation-selective channel activity|cell junction|axon|regulation of cell proliferation|inner ear morphogenesis|perikaryon|postsynaptic membrane|detection of mechanical stimulus involved in sensory perception of sound hsa04080 Neuroactive ligand-receptor interaction CHRNA3 9.2570745550372 9.7916193840393 8.72252972603509 0.890815848117333 -0.166800870173312 0.9263192210387 1 0.0729016 0.0663973 0.0573693 0.0428347 GeneID:1136,Genbank:NM_001166694.1,HGNC:HGNC:1957,MIM:118503 cholinergic receptor nicotinic alpha 3 subunit GO:0005886,GO:0005892,GO:0006811,GO:0006940,GO:0007165,GO:0007171,GO:0007271,GO:0007399,GO:0007626,GO:0014056,GO:0014069,GO:0015276,GO:0015464,GO:0016021,GO:0022848,GO:0022850,GO:0030054,GO:0030425,GO:0035095,GO:0042166,GO:0042391,GO:0043025,GO:0044853,GO:0045211,GO:0048814,GO:0060079,GO:0060084,GO:0095500,GO:1905144 plasma membrane|acetylcholine-gated channel complex|ion transport|regulation of smooth muscle contraction|signal transduction|activation of transmembrane receptor protein tyrosine kinase activity|synaptic transmission, cholinergic|nervous system development|locomotory behavior|regulation of acetylcholine secretion, neurotransmission|postsynaptic density|ligand-gated ion channel activity|acetylcholine receptor activity|integral component of membrane|acetylcholine-gated cation-selective channel activity|serotonin-gated cation-selective channel activity|cell junction|dendrite|behavioral response to nicotine|acetylcholine binding|regulation of membrane potential|neuronal cell body|plasma membrane raft|postsynaptic membrane|regulation of dendrite morphogenesis|excitatory postsynaptic potential|synaptic transmission involved in micturition|acetylcholine receptor signaling pathway|response to acetylcholine hsa04080,hsa04725 Neuroactive ligand-receptor interaction|Cholinergic synapse CHRNA5 714.800858092313 722.534321917672 707.067394266954 0.978593504583052 -0.0312183879767387 0.85402538981023 1 8.20554 8.26165 8.53918 8.14712 GeneID:1138,Genbank:NM_000745.3,HGNC:HGNC:1959,MIM:118505 cholinergic receptor nicotinic alpha 5 subunit GO:0005886,GO:0005892,GO:0007165,GO:0007268,GO:0007271,GO:0007274,GO:0015276,GO:0015464,GO:0022848,GO:0030054,GO:0035095,GO:0045211 plasma membrane|acetylcholine-gated channel complex|signal transduction|chemical synaptic transmission|synaptic transmission, cholinergic|neuromuscular synaptic transmission|ligand-gated ion channel activity|acetylcholine receptor activity|acetylcholine-gated cation-selective channel activity|cell junction|behavioral response to nicotine|postsynaptic membrane hsa04080 Neuroactive ligand-receptor interaction CHRNA7 4.03919955683607 3.22858605985383 4.8498130538183 1.50214767824336 0.587026653195826 0.813233786872319 1 0.0431902 0 0.0617833 0.0063975 GeneID:1139,Genbank:XM_017021884.1,HGNC:HGNC:1960,MIM:118511 cholinergic receptor nicotinic alpha 7 subunit GO:0000187,GO:0001540,GO:0001666,GO:0001934,GO:0005216,GO:0005262,GO:0005886,GO:0005892,GO:0006811,GO:0006816,GO:0006874,GO:0007165,GO:0007611,GO:0007613,GO:0007614,GO:0008284,GO:0015276,GO:0015464,GO:0015643,GO:0016021,GO:0017081,GO:0022848,GO:0030054,GO:0032720,GO:0034220,GO:0035094,GO:0042166,GO:0042803,GO:0044853,GO:0045211,GO:0045766,GO:0050808,GO:0050890,GO:0050893,GO:0051247,GO:0070374,GO:0095500,GO:0097061,GO:0098794,GO:0098815,GO:0140059,GO:1900273,GO:1901214,GO:1902004,GO:1902430,GO:1902991,GO:1904645,GO:1905144,GO:1905906,GO:1905920,GO:2000463 activation of MAPK activity|amyloid-beta binding|response to hypoxia|positive regulation of protein phosphorylation|ion channel activity|calcium channel activity|plasma membrane|acetylcholine-gated channel complex|ion transport|calcium ion transport|cellular calcium ion homeostasis|signal transduction|learning or memory|memory|short-term memory|positive regulation of cell proliferation|ligand-gated ion channel activity|acetylcholine receptor activity|toxic substance binding|integral component of membrane|chloride channel regulator activity|acetylcholine-gated cation-selective channel activity|cell junction|negative regulation of tumor necrosis factor production|ion transmembrane transport|response to nicotine|acetylcholine binding|protein homodimerization activity|plasma membrane raft|postsynaptic membrane|positive regulation of angiogenesis|synapse organization|cognition|sensory processing|positive regulation of protein metabolic process|positive regulation of ERK1 and ERK2 cascade|acetylcholine receptor signaling pathway|dendritic spine organization|postsynapse|modulation of excitatory postsynaptic potential|dendrite arborization|positive regulation of long-term synaptic potentiation|regulation of neuron death|positive regulation of amyloid-beta formation|negative regulation of amyloid-beta formation|regulation of amyloid precursor protein catabolic process|response to amyloid-beta|response to acetylcholine|regulation of amyloid fibril formation|positive regulation of CoA-transferase activity|positive regulation of excitatory postsynaptic potential hsa04020,hsa04080,hsa04725,hsa05033,hsa05204 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Cholinergic synapse|Nicotine addiction|Chemical carcinogenesis CHRNA9 1.48335117242078 1.02816907859967 1.93853326624189 1.88542264749112 0.914887962799843 0.868258168018795 1 0 0.0175318 0.0358423 0 GeneID:55584,Genbank:NM_017581.3,HGNC:HGNC:14079,MIM:605116 cholinergic receptor nicotinic alpha 9 subunit GO:0004888,GO:0005262,GO:0005886,GO:0005887,GO:0005892,GO:0007204,GO:0015276,GO:0022848,GO:0030054,GO:0042472,GO:0045211,GO:0050910 transmembrane signaling receptor activity|calcium channel activity|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|positive regulation of cytosolic calcium ion concentration|ligand-gated ion channel activity|acetylcholine-gated cation-selective channel activity|cell junction|inner ear morphogenesis|postsynaptic membrane|detection of mechanical stimulus involved in sensory perception of sound hsa04080 Neuroactive ligand-receptor interaction CHRNB1 159.533477856554 145.087509942139 173.979445770969 1.19913454879991 0.261993545320751 0.303908891205576 1 2.05696 2.51489 2.78478 2.67695 GeneID:1140,Genbank:NM_000747.2,HGNC:HGNC:1961,MIM:100710 cholinergic receptor nicotinic beta 1 subunit GO:0001941,GO:0003009,GO:0004888,GO:0005887,GO:0005892,GO:0006812,GO:0006936,GO:0007165,GO:0007271,GO:0007274,GO:0015267,GO:0015276,GO:0022848,GO:0030054,GO:0035095,GO:0042166,GO:0042391,GO:0045202,GO:0045211,GO:0048747,GO:0050877,GO:0098655 postsynaptic membrane organization|skeletal muscle contraction|transmembrane signaling receptor activity|integral component of plasma membrane|acetylcholine-gated channel complex|cation transport|muscle contraction|signal transduction|synaptic transmission, cholinergic|neuromuscular synaptic transmission|channel activity|ligand-gated ion channel activity|acetylcholine-gated cation-selective channel activity|cell junction|behavioral response to nicotine|acetylcholine binding|regulation of membrane potential|synapse|postsynaptic membrane|muscle fiber development|nervous system process|cation transmembrane transport hsa04080 Neuroactive ligand-receptor interaction CHRNB2 196.648992921293 220.78679456018 172.511191282406 0.781347415392569 -0.35596392933905 0.278532274584111 1 0.884797 0.642664 0.564455 0.675374 GeneID:1141,Genbank:NM_000748.2,HGNC:HGNC:1962,MIM:118507 cholinergic receptor nicotinic beta 2 subunit GO:0001508,GO:0001661,GO:0001666,GO:0005886,GO:0005892,GO:0006811,GO:0006816,GO:0006939,GO:0007165,GO:0007271,GO:0007274,GO:0007601,GO:0007605,GO:0007612,GO:0007613,GO:0007626,GO:0008306,GO:0008542,GO:0009897,GO:0014059,GO:0015276,GO:0015464,GO:0016021,GO:0019233,GO:0021562,GO:0021631,GO:0021771,GO:0021952,GO:0022848,GO:0030054,GO:0030890,GO:0032225,GO:0032226,GO:0033603,GO:0035094,GO:0035095,GO:0035176,GO:0042053,GO:0042113,GO:0042166,GO:0042220,GO:0042320,GO:0044853,GO:0045188,GO:0045211,GO:0045471,GO:0045759,GO:0046982,GO:0048814,GO:0050877,GO:0050890,GO:0051291,GO:0051899,GO:0051963,GO:0060084,GO:0095500,GO:1905144 action potential|conditioned taste aversion|response to hypoxia|plasma membrane|acetylcholine-gated channel complex|ion transport|calcium ion transport|smooth muscle contraction|signal transduction|synaptic transmission, cholinergic|neuromuscular synaptic transmission|visual perception|sensory perception of sound|learning|memory|locomotory behavior|associative learning|visual learning|external side of plasma membrane|regulation of dopamine secretion|ligand-gated ion channel activity|acetylcholine receptor activity|integral component of membrane|sensory perception of pain|vestibulocochlear nerve development|optic nerve morphogenesis|lateral geniculate nucleus development|central nervous system projection neuron axonogenesis|acetylcholine-gated cation-selective channel activity|cell junction|positive regulation of B cell proliferation|regulation of synaptic transmission, dopaminergic|positive regulation of synaptic transmission, dopaminergic|positive regulation of dopamine secretion|response to nicotine|behavioral response to nicotine|social behavior|regulation of dopamine metabolic process|B cell activation|acetylcholine binding|response to cocaine|regulation of circadian sleep/wake cycle, REM sleep|plasma membrane raft|regulation of circadian sleep/wake cycle, non-REM sleep|postsynaptic membrane|response to ethanol|negative regulation of action potential|protein heterodimerization activity|regulation of dendrite morphogenesis|nervous system process|cognition|protein heterooligomerization|membrane depolarization|regulation of synapse assembly|synaptic transmission involved in micturition|acetylcholine receptor signaling pathway|response to acetylcholine hsa04080,hsa04725,hsa05033 Neuroactive ligand-receptor interaction|Cholinergic synapse|Nicotine addiction CHRNB4 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0 0.00486023 0 0 GeneID:1143,Genbank:XM_011521187.2,HGNC:HGNC:1964,MIM:118509 cholinergic receptor nicotinic beta 4 subunit GO:0001508,GO:0005886,GO:0005887,GO:0005892,GO:0006811,GO:0006939,GO:0006940,GO:0007165,GO:0007271,GO:0007626,GO:0015276,GO:0015464,GO:0016021,GO:0022848,GO:0030054,GO:0035094,GO:0035095,GO:0035579,GO:0042166,GO:0043005,GO:0043312,GO:0045211,GO:0046928,GO:0046982,GO:0051291,GO:0051971,GO:0060084,GO:0070821 action potential|plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|ion transport|smooth muscle contraction|regulation of smooth muscle contraction|signal transduction|synaptic transmission, cholinergic|locomotory behavior|ligand-gated ion channel activity|acetylcholine receptor activity|integral component of membrane|acetylcholine-gated cation-selective channel activity|cell junction|response to nicotine|behavioral response to nicotine|specific granule membrane|acetylcholine binding|neuron projection|neutrophil degranulation|postsynaptic membrane|regulation of neurotransmitter secretion|protein heterodimerization activity|protein heterooligomerization|positive regulation of transmission of nerve impulse|synaptic transmission involved in micturition|tertiary granule membrane hsa04080,hsa04725 Neuroactive ligand-receptor interaction|Cholinergic synapse CHRND 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00836543 GeneID:1144,Genbank:NM_000751.2,HGNC:HGNC:1965,MIM:100720 cholinergic receptor nicotinic delta subunit GO:0003009,GO:0004888,GO:0005654,GO:0005829,GO:0005886,GO:0005892,GO:0006810,GO:0006936,GO:0007165,GO:0007271,GO:0007274,GO:0015276,GO:0022848,GO:0030054,GO:0035094,GO:0042166,GO:0045211,GO:0048630,GO:0050881,GO:0050905,GO:0098655 skeletal muscle contraction|transmembrane signaling receptor activity|nucleoplasm|cytosol|plasma membrane|acetylcholine-gated channel complex|transport|muscle contraction|signal transduction|synaptic transmission, cholinergic|neuromuscular synaptic transmission|ligand-gated ion channel activity|acetylcholine-gated cation-selective channel activity|cell junction|response to nicotine|acetylcholine binding|postsynaptic membrane|skeletal muscle tissue growth|musculoskeletal movement|neuromuscular process|cation transmembrane transport hsa04080 Neuroactive ligand-receptor interaction CHRNE 9.78679761057082 9.39760053145183 10.1759946896898 1.08282903232935 0.11480547408044 0.938989636991399 1 0.0629344 0.0548305 0.0388694 0.109136 GeneID:1145,Genbank:NM_000080.3,HGNC:HGNC:1966,MIM:100725 cholinergic receptor nicotinic epsilon subunit GO:0005886,GO:0005887,GO:0005892,GO:0006810,GO:0006936,GO:0007165,GO:0007271,GO:0007274,GO:0008324,GO:0015276,GO:0015464,GO:0022848,GO:0030054,GO:0035094,GO:0045211 plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|transport|muscle contraction|signal transduction|synaptic transmission, cholinergic|neuromuscular synaptic transmission|cation transmembrane transporter activity|ligand-gated ion channel activity|acetylcholine receptor activity|acetylcholine-gated cation-selective channel activity|cell junction|response to nicotine|postsynaptic membrane hsa04080 Neuroactive ligand-receptor interaction CHRNG 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:1146,Genbank:NM_005199.4,HGNC:HGNC:1967,MIM:100730 cholinergic receptor nicotinic gamma subunit GO:0005886,GO:0005887,GO:0005892,GO:0006810,GO:0006936,GO:0007165,GO:0007271,GO:0007274,GO:0015267,GO:0015276,GO:0015464,GO:0022848,GO:0030054,GO:0035094,GO:0045211,GO:0098655 plasma membrane|integral component of plasma membrane|acetylcholine-gated channel complex|transport|muscle contraction|signal transduction|synaptic transmission, cholinergic|neuromuscular synaptic transmission|channel activity|ligand-gated ion channel activity|acetylcholine receptor activity|acetylcholine-gated cation-selective channel activity|cell junction|response to nicotine|postsynaptic membrane|cation transmembrane transport hsa04080 Neuroactive ligand-receptor interaction CHST1 240.876034491586 211.312758789574 270.439310193597 1.27980587515258 0.355924994448707 0.0939075982788443 0.992100325879928 2.77655 2.44316 3.713 3.04746 GeneID:8534,Genbank:NM_003654.5,HGNC:HGNC:1969,MIM:603797 carbohydrate sulfotransferase 1 hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate CHST10 522.755440544054 537.617775248895 507.893105839214 0.944710404346435 -0.0820559478219734 0.63289568179058 1 4.50636 4.66315 4.66119 4.31683 GeneID:9486,Genbank:NM_004854.4,HGNC:HGNC:19650,MIM:606376 carbohydrate sulfotransferase 10 GO:0000139,GO:0005794,GO:0007155,GO:0008146,GO:0016020,GO:0016021,GO:0016051,GO:0016232 Golgi membrane|Golgi apparatus|cell adhesion|sulfotransferase activity|membrane|integral component of membrane|carbohydrate biosynthetic process|HNK-1 sulfotransferase activity hsa00515 Mannose type O-glycan biosynthesis CHST11 583.473257778279 652.234614375415 514.711901181143 0.78915146457542 -0.341625866613006 0.0421463397283458 0.765859201853198 4.26061 4.16805 3.69653 3.02404 GeneID:50515,Genbank:NM_018413.5,HGNC:HGNC:17422,MIM:610128 carbohydrate sulfotransferase 11 GO:0000139,GO:0001537,GO:0002063,GO:0007585,GO:0009791,GO:0016020,GO:0016021,GO:0016051,GO:0030206,GO:0030512,GO:0033037,GO:0036342,GO:0042127,GO:0042733,GO:0043066,GO:0047756,GO:0048589,GO:0048703,GO:0050659 Golgi membrane|N-acetylgalactosamine 4-O-sulfotransferase activity|chondrocyte development|respiratory gaseous exchange|post-embryonic development|membrane|integral component of membrane|carbohydrate biosynthetic process|chondroitin sulfate biosynthetic process|negative regulation of transforming growth factor beta receptor signaling pathway|polysaccharide localization|post-anal tail morphogenesis|regulation of cell proliferation|embryonic digit morphogenesis|negative regulation of apoptotic process|chondroitin 4-sulfotransferase activity|developmental growth|embryonic viscerocranium morphogenesis|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST12 785.270813567342 751.027123816954 819.51450331773 1.09119161922235 0.125904469056121 0.519136210888227 1 15.1629 18.802 19.9383 18.7675 GeneID:55501,Genbank:XM_011515444.2,HGNC:HGNC:17423,MIM:610129 carbohydrate sulfotransferase 12 GO:0000139,GO:0016020,GO:0016051,GO:0030173,GO:0030206,GO:0030208,GO:0047756,GO:0050656 Golgi membrane|membrane|carbohydrate biosynthetic process|integral component of Golgi membrane|chondroitin sulfate biosynthetic process|dermatan sulfate biosynthetic process|chondroitin 4-sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate binding hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST14 1088.12403414198 765.478308846288 1410.76975943767 1.84299116400038 0.88204915415724 7.65139076057365e-09 1.11404249473952e-05 18.7044 20.3504 38.1669 35.4329 GeneID:113189,Genbank:NM_130468.3,HGNC:HGNC:24464,MIM:608429 carbohydrate sulfotransferase 14 GO:0000139,GO:0001537,GO:0016021,GO:0016051,GO:0030208,GO:0042301,GO:0050655,GO:0070062 Golgi membrane|N-acetylgalactosamine 4-O-sulfotransferase activity|integral component of membrane|carbohydrate biosynthetic process|dermatan sulfate biosynthetic process|phosphate ion binding|dermatan sulfate proteoglycan metabolic process|extracellular exosome hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST15 39.6344768853017 40.012350171125 39.2566035994783 0.981112167407948 -0.027510010315967 0.948481997241221 1 0.114289 0.175968 0.165751 0.154766 GeneID:51363,Genbank:XM_005269894.5,HGNC:HGNC:18137,MIM:608277 carbohydrate sulfotransferase 15 GO:0000139,GO:0016021,GO:0019319,GO:0030206,GO:0050656,GO:0050659 Golgi membrane|integral component of membrane|hexose biosynthetic process|chondroitin sulfate biosynthetic process|3'-phosphoadenosine 5'-phosphosulfate binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST2 607.939208091712 474.371172432781 741.507243750643 1.56313723691908 0.644444446495569 0.000130029865503884 0.0274020832356607 6.16811 6.74848 11.0225 9.67978 GeneID:9435,Genbank:NM_004267.4,HGNC:HGNC:1970,MIM:603798 carbohydrate sulfotransferase 2 GO:0000139,GO:0001517,GO:0005794,GO:0005802,GO:0005975,GO:0006044,GO:0006790,GO:0006954,GO:0007275,GO:0008146,GO:0016021,GO:0018146,GO:0031228 Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|Golgi apparatus|trans-Golgi network|carbohydrate metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|inflammatory response|multicellular organism development|sulfotransferase activity|integral component of membrane|keratan sulfate biosynthetic process|intrinsic component of Golgi membrane hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate CHST3 6503.94298616028 4895.38660855518 8112.49936376538 1.6571723568447 0.728723660153578 3.63702700936845e-08 3.64066403637782e-05 20.4553 20.2001 36.7751 32.2205 GeneID:9469,Genbank:NM_004273.4,HGNC:HGNC:1971,MIM:603799 carbohydrate sulfotransferase 3 GO:0000139,GO:0001517,GO:0005975,GO:0006790,GO:0008146,GO:0008459,GO:0016021,GO:0030206 Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|carbohydrate metabolic process|sulfur compound metabolic process|sulfotransferase activity|chondroitin 6-sulfotransferase activity|integral component of membrane|chondroitin sulfate biosynthetic process hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST5 1.2383154714421 0.538097676642304 1.93853326624189 3.60256761994999 1.84902550994227 0.680597935457111 1 0.0188801 0 0.035049 0.032762 GeneID:23563,Genbank:NM_024533.4,HGNC:HGNC:1973,MIM:604817 carbohydrate sulfotransferase 5 GO:0000139,GO:0001517,GO:0005794,GO:0005975,GO:0006044,GO:0006477,GO:0006790,GO:0008146,GO:0016021,GO:0018146,GO:0031228 Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|Golgi apparatus|carbohydrate metabolic process|N-acetylglucosamine metabolic process|protein sulfation|sulfur compound metabolic process|sulfotransferase activity|integral component of membrane|keratan sulfate biosynthetic process|intrinsic component of Golgi membrane CHST6 15.1067065960405 16.6428103563344 13.5706028357466 0.815403321025134 -0.294414262151244 0.745507219805356 1 0.113531 0.0566532 0.0750989 0.0600095 GeneID:4166,Genbank:NM_021615.4,HGNC:HGNC:6938,MIM:605294 carbohydrate sulfotransferase 6 GO:0000139,GO:0001517,GO:0005794,GO:0005975,GO:0006044,GO:0006790,GO:0016021,GO:0018146 Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|Golgi apparatus|carbohydrate metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|integral component of membrane|keratan sulfate biosynthetic process hsa00533 Glycosaminoglycan biosynthesis - keratan sulfate CHST7 221.806528100585 219.211736150685 224.401320050486 1.02367384151474 0.0337561233622056 0.897260968224874 1 6.44707 6.25469 7.21784 5.80536 GeneID:56548,Genbank:NM_019886.3,HGNC:HGNC:13817,MIM:300375 carbohydrate sulfotransferase 7 GO:0000139,GO:0001517,GO:0005976,GO:0006044,GO:0006790,GO:0008459,GO:0016021,GO:0030206 Golgi membrane|N-acetylglucosamine 6-O-sulfotransferase activity|polysaccharide metabolic process|N-acetylglucosamine metabolic process|sulfur compound metabolic process|chondroitin 6-sulfotransferase activity|integral component of membrane|chondroitin sulfate biosynthetic process hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHST9 2.91867607015661 1.96028560782945 3.87706653248377 1.97780696700452 0.983901626635446 0.690391127950819 1 0 0.0167731 0.00832298 0.00388004 GeneID:83539,Genbank:XM_017026034.1,HGNC:HGNC:19898,MIM:610191 carbohydrate sulfotransferase 9 GO:0000139,GO:0001537,GO:0005576,GO:0006790,GO:0016021,GO:0016051,GO:0030166,GO:0030203,GO:0030206,GO:0042446,GO:0047756 Golgi membrane|N-acetylgalactosamine 4-O-sulfotransferase activity|extracellular region|sulfur compound metabolic process|integral component of membrane|carbohydrate biosynthetic process|proteoglycan biosynthetic process|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|hormone biosynthetic process|chondroitin 4-sulfotransferase activity CHSY1 1652.90578363637 1793.74343999532 1512.06812727742 0.842967892488215 -0.246450412984745 0.085165365261049 0.964561165794104 13.7005 13.8669 12.2515 11.1419 GeneID:22856,Genbank:NM_014918.4,HGNC:HGNC:17198,MIM:608183 chondroitin sulfate synthase 1 hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHSY3 154.915054071586 154.244979100166 155.585129043006 1.00868845099956 0.0124806446091004 0.995889997312297 1 0.270539 0.344131 0.363949 0.266369 GeneID:337876,Genbank:XM_011543363.3,HGNC:HGNC:24293,MIM:609963 chondroitin sulfate synthase 3 hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CHTF18 556.077744564329 552.906041258943 559.249447869716 1.01147284735093 0.0164575917519134 0.942193090399801 1 6.29339 6.18283 6.97296 6.71268 GeneID:63922,Genbank:NM_022092.2,HGNC:HGNC:18435,MIM:613201 chromosome transmission fidelity factor 18 GO:0003677,GO:0005524,GO:0005654,GO:0005829,GO:0006260,GO:0007049,GO:0016020,GO:0031390,GO:1900264 DNA binding|ATP binding|nucleoplasm|cytosol|DNA replication|cell cycle|membrane|Ctf18 RFC-like complex|positive regulation of DNA-directed DNA polymerase activity CHTF8 3012.01546157733 2883.71055851716 3140.3203646375 1.08898597862481 0.122985378573936 0.373573927494174 1 34.122 35.5357 38.7766 38.4748 GeneID:54921,Genbank:NM_001039690.3,HGNC:HGNC:24353,MIM:613202 chromosome transmission fidelity factor 8 GO:0003677,GO:0005634,GO:0006260,GO:0007064,GO:0031390,GO:1900264 DNA binding|nucleus|DNA replication|mitotic sister chromatid cohesion|Ctf18 RFC-like complex|positive regulation of DNA-directed DNA polymerase activity CHTOP 2290.18542021668 2307.02337528233 2273.34746515103 0.985402874330575 -0.021214415020888 0.860756449001279 1 38.24 41.8796 40.2716 40.6146 GeneID:26097,Genbank:NM_001206612.1,HGNC:HGNC:24511,MIM:614206 chromatin target of PRMT1 GO:0000346,GO:0003723,GO:0005730,GO:0006351,GO:0006355,GO:0006406,GO:0008284,GO:0008327,GO:0016607,GO:0031062,GO:0032781,GO:0036464,GO:0051096 transcription export complex|RNA binding|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA export from nucleus|positive regulation of cell proliferation|methyl-CpG binding|nuclear speck|positive regulation of histone methylation|positive regulation of ATPase activity|cytoplasmic ribonucleoprotein granule|positive regulation of helicase activity CHUK 751.659837087465 842.683991288068 660.635682886862 0.783966100835807 -0.351136822196653 0.235302222430081 1 4.59637 3.6716 3.93767 2.79909 GeneID:1147,Genbank:NM_001320928.1,HGNC:HGNC:1974,MIM:600664 conserved helix-loop-helix ubiquitous kinase hsa01523,hsa04010,hsa04014,hsa04062,hsa04064,hsa04068,hsa04150,hsa04151,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04920,hsa05120,hsa05131,hsa05142,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05418 Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Fluid shear stress and atherosclerosis CHURC1 235.847510277237 224.525069332207 247.169951222268 1.10085680836181 0.13862682557705 0.508642366830648 1 3.24765 3.16893 3.7209 3.64693 GeneID:91612,Genbank:NM_145165.3,HGNC:HGNC:20099,MIM:608577 churchill domain containing 1 GO:0006351,GO:0007275,GO:0008270,GO:0045893 transcription, DNA-templated|multicellular organism development|zinc ion binding|positive regulation of transcription, DNA-templated CIAO1 1945.98005215178 1986.90699060482 1905.05311369873 0.958803367599418 -0.0606931187221273 0.647291919525473 1 16.9674 18.9096 17.7067 17.0428 GeneID:9391,Genbank:NM_004804.2,HGNC:HGNC:14280,MIM:604333 cytosolic iron-sulfur assembly component 1 GO:0006357,GO:0007059,GO:0008284,GO:0016226,GO:0071817,GO:0097361 regulation of transcription from RNA polymerase II promoter|chromosome segregation|positive regulation of cell proliferation|iron-sulfur cluster assembly|MMXD complex|CIA complex CIAPIN1 1746.17394284726 1845.60476470854 1646.74312098597 0.892251229772928 -0.164478110172513 0.241285335648172 1 32.2548 34.4349 30.3466 30.0264 GeneID:57019,Genbank:NM_001308347.1,HGNC:HGNC:28050,MIM:608943 cytokine induced apoptosis inhibitor 1 GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005758,GO:0006915,GO:0008168,GO:0016226,GO:0030097,GO:0043066,GO:0046872,GO:0051537 nucleoplasm|nucleolus|cytoplasm|mitochondrion|mitochondrial intermembrane space|apoptotic process|methyltransferase activity|iron-sulfur cluster assembly|hemopoiesis|negative regulation of apoptotic process|metal ion binding|2 iron, 2 sulfur cluster binding CIART 153.446067726574 142.617535622136 164.274599831012 1.15185414692802 0.203958047660996 0.409121027751231 1 2.38494 1.97764 2.56392 2.93471 GeneID:148523,Genbank:NM_144697.3,HGNC:HGNC:25200,MIM:615782 circadian associated repressor of transcription GO:0001046,GO:0005634,GO:0006351,GO:0016605,GO:0032922,GO:0045475,GO:0045892,GO:0070888 core promoter sequence-specific DNA binding|nucleus|transcription, DNA-templated|PML body|circadian regulation of gene expression|locomotor rhythm|negative regulation of transcription, DNA-templated|E-box binding CIB1 1595.55975816774 1615.78496250417 1575.3345538313 0.974965475226246 -0.0365769627961581 0.858716932023156 1 23.5178 22.4535 20.4101 24.7922 GeneID:10519,Genbank:NM_006384.3,HGNC:HGNC:16920,MIM:602293 calcium and integrin binding 1 GO:0001525,GO:0001933,GO:0001934,GO:0001954,GO:0002931,GO:0005509,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005794,GO:0005813,GO:0005886,GO:0006302,GO:0006915,GO:0006974,GO:0007026,GO:0007113,GO:0007155,GO:0007286,GO:0008022,GO:0008284,GO:0008285,GO:0008427,GO:0010977,GO:0016020,GO:0016324,GO:0017016,GO:0019901,GO:0030027,GO:0030220,GO:0030291,GO:0030307,GO:0030335,GO:0030424,GO:0030425,GO:0030426,GO:0031122,GO:0031982,GO:0032433,GO:0032587,GO:0033630,GO:0038163,GO:0042127,GO:0042383,GO:0043005,GO:0043025,GO:0043066,GO:0043085,GO:0043495,GO:0044325,GO:0045653,GO:0048471,GO:0051092,GO:0051301,GO:0051302,GO:0051898,GO:0070062,GO:0070374,GO:0070886,GO:0071356,GO:0071363,GO:0071902,GO:0071944,GO:0090050,GO:0090314,GO:0097191,GO:1900026,GO:1903078,GO:1990090,GO:2000256 angiogenesis|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of cell-matrix adhesion|response to ischemia|calcium ion binding|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|Golgi apparatus|centrosome|plasma membrane|double-strand break repair|apoptotic process|cellular response to DNA damage stimulus|negative regulation of microtubule depolymerization|endomitotic cell cycle|cell adhesion|spermatid development|protein C-terminus binding|positive regulation of cell proliferation|negative regulation of cell proliferation|calcium-dependent protein kinase inhibitor activity|negative regulation of neuron projection development|membrane|apical plasma membrane|Ras GTPase binding|protein kinase binding|lamellipodium|platelet formation|protein serine/threonine kinase inhibitor activity|positive regulation of cell growth|positive regulation of cell migration|axon|dendrite|growth cone|cytoplasmic microtubule organization|vesicle|filopodium tip|ruffle membrane|positive regulation of cell adhesion mediated by integrin|thrombopoietin-mediated signaling pathway|regulation of cell proliferation|sarcolemma|neuron projection|neuronal cell body|negative regulation of apoptotic process|positive regulation of catalytic activity|protein membrane anchor|ion channel binding|negative regulation of megakaryocyte differentiation|perinuclear region of cytoplasm|positive regulation of NF-kappaB transcription factor activity|cell division|regulation of cell division|negative regulation of protein kinase B signaling|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|positive regulation of calcineurin-NFAT signaling cascade|cellular response to tumor necrosis factor|cellular response to growth factor stimulus|positive regulation of protein serine/threonine kinase activity|cell periphery|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of protein targeting to membrane|extrinsic apoptotic signaling pathway|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of protein localization to plasma membrane|cellular response to nerve growth factor stimulus|positive regulation of male germ cell proliferation CIB2 136.970379962564 135.824179579634 138.116580345494 1.01687770743733 0.0241461870790773 0.945426029428399 1 1.6702 1.48643 1.75564 1.7174 GeneID:10518,Genbank:NM_001271889.1,HGNC:HGNC:24579,MIM:605564 calcium and integrin binding family member 2 GO:0000287,GO:0001750,GO:0001917,GO:0005178,GO:0005509,GO:0005737,GO:0005927,GO:0007204,GO:0031594,GO:0032420,GO:0032437,GO:0042383,GO:0042803,GO:0045494,GO:0055074,GO:0071318,GO:0072562 magnesium ion binding|photoreceptor outer segment|photoreceptor inner segment|integrin binding|calcium ion binding|cytoplasm|muscle tendon junction|positive regulation of cytosolic calcium ion concentration|neuromuscular junction|stereocilium|cuticular plate|sarcolemma|protein homodimerization activity|photoreceptor cell maintenance|calcium ion homeostasis|cellular response to ATP|blood microparticle CIC 2873.95115818948 2736.81766744721 3011.08464893176 1.10021383037197 0.137783943783605 0.324426801138709 1 12.6851 12.625 14.9106 13.5754 GeneID:23152,Genbank:NM_001304815.1,HGNC:HGNC:14214,MIM:612082 capicua transcriptional repressor GO:0000122,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0006351,GO:0007420,GO:0007612,GO:0007613,GO:0035176,GO:0043231,GO:0043234,GO:0045892,GO:0048286 negative regulation of transcription from RNA polymerase II promoter|DNA binding|chromatin binding|nucleus|nucleoplasm|transcription, DNA-templated|brain development|learning|memory|social behavior|intracellular membrane-bounded organelle|protein complex|negative regulation of transcription, DNA-templated|lung alveolus development CIDEB 77.0596383450054 92.0931719466976 62.0261047433132 0.673514696390446 -0.570218668608409 0.0897848277243398 0.979717040875575 0.402387 0.268684 0.250783 0.26134 GeneID:27141,Genbank:NM_014430.2,HGNC:HGNC:1977,MIM:604441 cell death-inducing DFFA-like effector b GO:0001632,GO:0004974,GO:0005654,GO:0005886,GO:0005887,GO:0006935,GO:0007186,GO:0007194,GO:0007200,GO:0007218,GO:0008528,GO:0016020,GO:0051546 leukotriene B4 receptor activity|leukotriene receptor activity|nucleoplasm|plasma membrane|integral component of plasma membrane|chemotaxis|G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|phospholipase C-activating G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|G-protein coupled peptide receptor activity|membrane|keratinocyte migration CIDEC 2.75655595199912 3.57457863775636 1.93853326624189 0.542310986186231 -0.882807697988325 0.716599193465425 1 0.030751 0 0.0571358 0.0534626 GeneID:63924,Genbank:NM_001321144.1,HGNC:HGNC:24229,MIM:612120 cell death inducing DFFA like effector c GO:0005634,GO:0005783,GO:0005811,GO:0005829,GO:0006351,GO:0006355,GO:0006915,GO:0034389,GO:0042981,GO:0097194 nucleus|endoplasmic reticulum|lipid droplet|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|lipid particle organization|regulation of apoptotic process|execution phase of apoptosis CILP 1.26483015846966 1.07619535328461 1.45346496365472 1.35055866875717 0.43355631240266 1 1 0.0119168 0 0.0056119 0.0104726 GeneID:8483,Genbank:NM_003613.3,HGNC:HGNC:1980,MIM:603489 cartilage intermediate layer protein GO:0005578,GO:0005615,GO:0031012,GO:0043569,GO:0070062 proteinaceous extracellular matrix|extracellular space|extracellular matrix|negative regulation of insulin-like growth factor receptor signaling pathway|extracellular exosome CILP2 6.52409675435384 6.26506702096788 6.78312648773981 1.08269017155572 0.114620452632087 0.978321861858245 1 0.096222 0.0457941 0.0626906 0.105814 GeneID:148113,Genbank:NM_153221.2,HGNC:HGNC:24213,MIM:612419 cartilage intermediate layer protein 2 GO:0005578,GO:0070062 proteinaceous extracellular matrix|extracellular exosome CINP 450.653734906716 428.804340705854 472.503129107579 1.10190845626654 0.140004373477 0.430815212010077 1 15.5671 14.8417 16.7683 15.8719 GeneID:51550,Genbank:NM_001320046.1,HGNC:HGNC:23789,MIM:613362 cyclin dependent kinase 2 interacting protein GO:0005634,GO:0006260,GO:0006281,GO:0007049,GO:0051301 nucleus|DNA replication|DNA repair|cell cycle|cell division CIP2A 359.426643646519 383.429614077667 335.42367321537 0.874798557284695 -0.192977253787972 0.576322115732139 1 1.86285 1.55048 1.83449 1.11612 GeneID:57650,Genbank:XM_011513057.2,HGNC:HGNC:29302,MIM:610643 cell proliferation regulating inhibitor of protein phosphatase 2A CIPC 225.223899987423 217.808148528859 232.639651445987 1.06809434365659 0.0950390843982489 0.642163384320721 1 2.52111 1.98039 2.73097 2.177 GeneID:85457,Genbank:NM_033426.2,HGNC:HGNC:20365,MIM:616995 CLOCK interacting pacemaker GO:0005634,GO:0005829,GO:0006351,GO:0042754,GO:0045892,GO:0048511 nucleus|cytosol|transcription, DNA-templated|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|rhythmic process CIR1 113.578188085003 96.3019008104661 130.854475359541 1.35879431515146 0.442327087474617 0.113744228538665 1 1.30027 1.1401 1.90427 1.65158 GeneID:9541,Genbank:NM_004882.3,HGNC:HGNC:24217,MIM:605228 corepressor interacting with RBPJ, 1 GO:0003700,GO:0003705,GO:0003714,GO:0005634,GO:0005737,GO:0005815,GO:0006351,GO:0006397,GO:0008380,GO:0016607,GO:0019901,GO:0043234,GO:0045892 DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|transcription corepressor activity|nucleus|cytoplasm|microtubule organizing center|transcription, DNA-templated|mRNA processing|RNA splicing|nuclear speck|protein kinase binding|protein complex|negative regulation of transcription, DNA-templated hsa04330,hsa05169 Notch signaling pathway|Epstein-Barr virus infection CIRBP 3426.95746131523 3525.75953465595 3328.15538797452 0.943954162290677 -0.0832112897933678 0.56335784883938 1 45.8317 46.9354 42.3229 48.0706 GeneID:1153,Genbank:NM_001300815.1,HGNC:HGNC:1982,MIM:602649 cold inducible RNA binding protein GO:0003723,GO:0003730,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0009409,GO:0009411,GO:0010494,GO:0030371,GO:0034063,GO:0045727,GO:0048255,GO:0070181 RNA binding|mRNA 3'-UTR binding|nucleus|nucleoplasm|nucleolus|cytoplasm|response to cold|response to UV|cytoplasmic stress granule|translation repressor activity|stress granule assembly|positive regulation of translation|mRNA stabilization|small ribosomal subunit rRNA binding CISD1 802.827708538438 798.272841156145 807.382575920731 1.01141180595771 0.0163705238954519 0.915965453064193 1 15.9119 16.776 16.538 16.4975 GeneID:55847,Genbank:NM_018464.4,HGNC:HGNC:30880,MIM:611932 CDGSH iron sulfur domain 1 GO:0005739,GO:0005741,GO:0016021,GO:0042802,GO:0043457,GO:0046872,GO:0051537,GO:0070062 mitochondrion|mitochondrial outer membrane|integral component of membrane|identical protein binding|regulation of cellular respiration|metal ion binding|2 iron, 2 sulfur cluster binding|extracellular exosome CISD2 921.542039368748 978.020133467454 865.063945270041 0.884505252671087 -0.17705738444192 0.254005016749299 1 7.52375 7.98265 7.15367 6.7649 GeneID:493856,Genbank:NM_001008388.4,HGNC:HGNC:24212,MIM:611507 CDGSH iron sulfur domain 2 GO:0000422,GO:0003723,GO:0005741,GO:0005783,GO:0005789,GO:0010259,GO:0010506,GO:0016020,GO:0016021,GO:0042803,GO:0043234,GO:0046872,GO:0051537 autophagy of mitochondrion|RNA binding|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|multicellular organism aging|regulation of autophagy|membrane|integral component of membrane|protein homodimerization activity|protein complex|metal ion binding|2 iron, 2 sulfur cluster binding CISD3 1073.865990762 1137.35894868679 1010.37303283722 0.888350185316437 -0.170799599584529 0.263029327005705 1 12.0417 13.3993 10.8149 12.3096 GeneID:284106,Genbank:NM_001136498.1,HGNC:HGNC:27578,MIM:611933 CDGSH iron sulfur domain 3 GO:0005739,GO:0046872,GO:0051537 mitochondrion|metal ion binding|2 iron, 2 sulfur cluster binding CISH 17.9459709925695 21.8414906791256 14.0504513060134 0.64329177492641 -0.636454852260232 0.34287757706575 1 0.129586 0.165497 0.0606428 0.127656 GeneID:1154,Genbank:NM_145071.2,HGNC:HGNC:1984,MIM:602441 cytokine inducible SH2 containing protein GO:0001558,GO:0004860,GO:0005737,GO:0005829,GO:0005886,GO:0006469,GO:0007205,GO:0016567,GO:0019221,GO:0035556,GO:0038111,GO:0043687,GO:0046426,GO:0046627 regulation of cell growth|protein kinase inhibitor activity|cytoplasm|cytosol|plasma membrane|negative regulation of protein kinase activity|protein kinase C-activating G-protein coupled receptor signaling pathway|protein ubiquitination|cytokine-mediated signaling pathway|intracellular signal transduction|interleukin-7-mediated signaling pathway|post-translational protein modification|negative regulation of JAK-STAT cascade|negative regulation of insulin receptor signaling pathway hsa04630,hsa04917 Jak-STAT signaling pathway|Prolactin signaling pathway CIT 1396.83819252313 1404.17220340967 1389.50418163658 0.989553972271013 -0.0151496979690718 0.926546150826792 1 4.03919 3.79583 4.26674 3.67262 GeneID:11113,Genbank:NM_007174.2,HGNC:HGNC:1985,MIM:605629 citron rho-interacting serine/threonine kinase GO:0000086,GO:0000278,GO:0000281,GO:0004674,GO:0005524,GO:0005829,GO:0005886,GO:0007030,GO:0008064,GO:0016020,GO:0017048,GO:0017124,GO:0030165,GO:0030496,GO:0031985,GO:0032154,GO:0032467,GO:0035556,GO:0043025,GO:0046872,GO:0048699,GO:0051402,GO:0097110 G2/M transition of mitotic cell cycle|mitotic cell cycle|mitotic cytokinesis|protein serine/threonine kinase activity|ATP binding|cytosol|plasma membrane|Golgi organization|regulation of actin polymerization or depolymerization|membrane|Rho GTPase binding|SH3 domain binding|PDZ domain binding|midbody|Golgi cisterna|cleavage furrow|positive regulation of cytokinesis|intracellular signal transduction|neuronal cell body|metal ion binding|generation of neurons|neuron apoptotic process|scaffold protein binding CITED1 14.5017668388375 12.0400626399784 16.9634710376966 1.40891883580159 0.494588504082429 0.508249820837714 1 0.637866 0.241711 0.589487 0.480056 GeneID:4435,Genbank:NM_001144886.1,HGNC:HGNC:1986,MIM:300149 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1 GO:0000578,GO:0001105,GO:0001570,GO:0001656,GO:0001658,GO:0001890,GO:0003340,GO:0003682,GO:0003700,GO:0003713,GO:0005634,GO:0005737,GO:0005829,GO:0006357,GO:0006913,GO:0006915,GO:0007179,GO:0007420,GO:0008022,GO:0008283,GO:0010628,GO:0030178,GO:0030318,GO:0030511,GO:0032496,GO:0032868,GO:0034097,GO:0034341,GO:0042438,GO:0042803,GO:0042981,GO:0043473,GO:0043524,GO:0043627,GO:0044212,GO:0045668,GO:0045892,GO:0045893,GO:0050693,GO:0051591,GO:0060231,GO:0060395,GO:0060711,GO:0060712,GO:0070410,GO:0070555,GO:0070669,GO:0070670,GO:0070741,GO:0071104,GO:0071105,GO:0071107,GO:0071559 embryonic axis specification|RNA polymerase II transcription coactivator activity|vasculogenesis|metanephros development|branching involved in ureteric bud morphogenesis|placenta development|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|chromatin binding|DNA binding transcription factor activity|transcription coactivator activity|nucleus|cytoplasm|cytosol|regulation of transcription from RNA polymerase II promoter|nucleocytoplasmic transport|apoptotic process|transforming growth factor beta receptor signaling pathway|brain development|protein C-terminus binding|cell proliferation|positive regulation of gene expression|negative regulation of Wnt signaling pathway|melanocyte differentiation|positive regulation of transforming growth factor beta receptor signaling pathway|response to lipopolysaccharide|response to insulin|response to cytokine|response to interferon-gamma|melanin biosynthetic process|protein homodimerization activity|regulation of apoptotic process|pigmentation|negative regulation of neuron apoptotic process|response to estrogen|transcription regulatory region DNA binding|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|LBD domain binding|response to cAMP|mesenchymal to epithelial transition|SMAD protein signal transduction|labyrinthine layer development|spongiotrophoblast layer development|co-SMAD binding|response to interleukin-1|response to interleukin-2|response to interleukin-4|response to interleukin-6|response to interleukin-9|response to interleukin-11|response to parathyroid hormone|response to transforming growth factor beta CITED2 1250.97333130153 1268.12852676769 1233.81813583538 0.972944074509737 -0.0395712145945275 0.776735621300546 1 24.6755 26.0562 24.9103 25.3338 GeneID:10370,Genbank:NM_006079.4,HGNC:HGNC:1987,MIM:602937 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 hsa04137 Mitophagy - animal CITED4 11.902701047011 15.0863522562004 8.7190498378215 0.577942877758142 -0.79100118701868 0.454520215967972 1 0.597042 1.43704 0.307643 1.0067 GeneID:163732,Genbank:NM_133467.2,HGNC:HGNC:18696,MIM:606815 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 CIZ1 2524.83074833898 2571.32066341224 2478.34083326571 0.963839659724455 -0.0531349290962325 0.68503038827284 1 18.8835 18.8422 18.3127 18.0323 GeneID:25792,Genbank:NM_001131015.1,HGNC:HGNC:16744,MIM:611420 CDKN1A interacting zinc finger protein 1 CKAP2 750.101320228486 779.447197127062 720.755443329909 0.924700795623509 -0.112941464932595 0.721095806954373 1 6.41293 5.46912 6.63147 4.40133 GeneID:26586,Genbank:NM_001098525.2,HGNC:HGNC:1990,MIM:611569 cytoskeleton associated protein 2 GO:0000281,GO:0000922,GO:0005813,GO:0005829,GO:0005881,GO:0006915,GO:0007026,GO:0015630,GO:0045944 mitotic cytokinesis|spindle pole|centrosome|cytosol|cytoplasmic microtubule|apoptotic process|negative regulation of microtubule depolymerization|microtubule cytoskeleton|positive regulation of transcription from RNA polymerase II promoter CKAP2L 411.961365969144 415.322472824472 408.600259113815 0.983814471523917 -0.0235418181934364 0.942389034864383 1 2.5942 2.48343 3.07332 2.1176 GeneID:150468,Genbank:NM_001304361.1,HGNC:HGNC:26877,MIM:616174 cytoskeleton associated protein 2 like GO:0000922,GO:0005813,GO:0005829,GO:0072686 spindle pole|centrosome|cytosol|mitotic spindle CKAP4 9083.18755689677 8327.53879878729 9838.83631500626 1.18148189431901 0.240597520825664 0.0681832749433966 0.917687571238293 115.675 122.221 152.305 133.041 GeneID:10970,Genbank:NM_006825.3,HGNC:HGNC:16991 cytoskeleton associated protein 4 GO:0003723,GO:0005783,GO:0005788,GO:0005789,GO:0005791,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0016020,GO:0016021,GO:0016607,GO:0031012,GO:0035577,GO:0035579,GO:0036464,GO:0042599,GO:0043312,GO:0043687,GO:0044267,GO:0048471,GO:0070062 RNA binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|rough endoplasmic reticulum|lipid droplet|cytosol|cytoskeleton|plasma membrane|membrane|integral component of membrane|nuclear speck|extracellular matrix|azurophil granule membrane|specific granule membrane|cytoplasmic ribonucleoprotein granule|lamellar body|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|perinuclear region of cytoplasm|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum CKAP5 4822.03719125928 5058.10855296095 4585.96582955761 0.906656269144925 -0.141372393957746 0.423860937375368 1 22.6405 19.9704 21.9885 17.1319 GeneID:9793,Genbank:NM_014756.3,HGNC:HGNC:28959,MIM:611142 cytoskeleton associated protein 5 GO:0000086,GO:0000776,GO:0000777,GO:0000922,GO:0005730,GO:0005813,GO:0005829,GO:0005886,GO:0007019,GO:0007051,GO:0007062,GO:0007098,GO:0010389,GO:0016020,GO:0030951,GO:0043234,GO:0045296,GO:0046785,GO:0050658,GO:0051010,GO:0051298,GO:0051301,GO:0097711 G2/M transition of mitotic cell cycle|kinetochore|condensed chromosome kinetochore|spindle pole|nucleolus|centrosome|cytosol|plasma membrane|microtubule depolymerization|spindle organization|sister chromatid cohesion|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|membrane|establishment or maintenance of microtubule cytoskeleton polarity|protein complex|cadherin binding|microtubule polymerization|RNA transport|microtubule plus-end binding|centrosome duplication|cell division|ciliary basal body-plasma membrane docking CKB 10491.0779000082 9877.55545123068 11104.6003487858 1.12422556406932 0.168931526231399 0.280822849578937 1 225.959 239.037 258.911 280 GeneID:1152,Genbank:NM_001823.4,HGNC:HGNC:1991,MIM:123280 creatine kinase B hsa00330 Arginine and proline metabolism CKLF 17.4539413934289 19.8812050712962 15.0266777155615 0.755823284437446 -0.403879130900505 0.566597869108517 1 75.8638 84.0692 72.6482 79.3311 GeneID:51192,Genbank:NM_016951.3,HGNC:HGNC:13253,MIM:616074 chemokine like factor CKMT1A 2.96670234484155 2.05633815719933 3.87706653248377 1.88542264749112 0.914887962799843 0.688085907961971 1 0.0306584 0.0273249 0.0573082 0.0266856 GeneID:548596,Genbank:XM_017022371.1,HGNC:HGNC:31736,MIM:613415 creatine kinase, mitochondrial 1A GO:0004111,GO:0005524,GO:0005739,GO:0005743,GO:0006600,GO:0070062 creatine kinase activity|ATP binding|mitochondrion|mitochondrial inner membrane|creatine metabolic process|extracellular exosome hsa00330 Arginine and proline metabolism CKMT1B 10.8633066772122 7.19718355019767 14.5294298042268 2.01876604964837 1.01347372960523 0.533311643819156 1 0.113792 0.10177 0.0913003 0.34007 GeneID:1159,Genbank:NM_020990.4,HGNC:HGNC:1995,MIM:123290 creatine kinase, mitochondrial 1B GO:0004111,GO:0005524,GO:0005739,GO:0005743,GO:0006600,GO:0070062 creatine kinase activity|ATP binding|mitochondrion|mitochondrial inner membrane|creatine metabolic process|extracellular exosome hsa00330 Arginine and proline metabolism CKMT2 5.12409615078096 7.34126237425249 2.90692992730943 0.395971398257704 -1.33653186933502 0.357086046388223 1 0.0512377 0.0427682 0.0148227 0.0239759 GeneID:1160,Genbank:XM_024454356.1,HGNC:HGNC:1996,MIM:123295 creatine kinase, mitochondrial 2 GO:0004111,GO:0005524,GO:0005739,GO:0005743,GO:0006600,GO:0006936 creatine kinase activity|ATP binding|mitochondrion|mitochondrial inner membrane|creatine metabolic process|muscle contraction hsa00330 Arginine and proline metabolism CKS1B 2024.90523423991 2120.07889942082 1929.73156905899 0.910216864846949 -0.135717777526929 0.321762019315867 1 102.254 112.961 98.4074 101.448 GeneID:1163,Genbank:NM_001826.2,HGNC:HGNC:19083,MIM:116900 CDC28 protein kinase regulatory subunit 1B hsa05200,hsa05222 Pathways in cancer|Small cell lung cancer CKS2 3024.92779893061 3244.03139846453 2805.82419939669 0.864918940280524 -0.209363164375129 0.12174176544251 1 232.887 251.184 198.65 218.957 GeneID:1164,Genbank:NM_001827.2,HGNC:HGNC:2000,MIM:116901 CDC28 protein kinase regulatory subunit 2 hsa05200,hsa05222 Pathways in cancer|Small cell lung cancer CLASP1 875.818730818611 849.643077466551 901.994384170671 1.06161564554874 0.0862615376794982 0.615029316998722 1 2.24001 2.27337 2.87075 2.12029 GeneID:23332,Genbank:NM_001142274.1,HGNC:HGNC:17088,MIM:605852 cytoplasmic linker associated protein 1 GO:0000086,GO:0000226,GO:0000776,GO:0000777,GO:0001578,GO:0002162,GO:0005794,GO:0005813,GO:0005828,GO:0005829,GO:0005876,GO:0005881,GO:0005938,GO:0006903,GO:0007020,GO:0007026,GO:0007030,GO:0007052,GO:0007062,GO:0007163,GO:0008017,GO:0010389,GO:0010458,GO:0010470,GO:0010634,GO:0010717,GO:0016020,GO:0030953,GO:0030981,GO:0031023,GO:0031111,GO:0031116,GO:0031592,GO:0034453,GO:0035371,GO:0040001,GO:0043515,GO:0045180,GO:0045921,GO:0051010,GO:0051294,GO:0051301,GO:0051497,GO:0051893,GO:0070062,GO:0070507,GO:0090091,GO:0090162,GO:0090307,GO:0097711,GO:1903690,GO:1904261 G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|kinetochore|condensed chromosome kinetochore|microtubule bundle formation|dystroglycan binding|Golgi apparatus|centrosome|kinetochore microtubule|cytosol|spindle microtubule|cytoplasmic microtubule|cell cortex|vesicle targeting|microtubule nucleation|negative regulation of microtubule depolymerization|Golgi organization|mitotic spindle organization|sister chromatid cohesion|establishment or maintenance of cell polarity|microtubule binding|regulation of G2/M transition of mitotic cell cycle|exit from mitosis|regulation of gastrulation|positive regulation of epithelial cell migration|regulation of epithelial to mesenchymal transition|membrane|astral microtubule organization|cortical microtubule cytoskeleton|microtubule organizing center organization|negative regulation of microtubule polymerization or depolymerization|positive regulation of microtubule polymerization|centrosomal corona|microtubule anchoring|microtubule plus-end|establishment of mitotic spindle localization|kinetochore binding|basal cortex|positive regulation of exocytosis|microtubule plus-end binding|establishment of spindle orientation|cell division|negative regulation of stress fiber assembly|regulation of focal adhesion assembly|extracellular exosome|regulation of microtubule cytoskeleton organization|positive regulation of extracellular matrix disassembly|establishment of epithelial cell polarity|mitotic spindle assembly|ciliary basal body-plasma membrane docking|negative regulation of wound healing, spreading of epidermal cells|positive regulation of basement membrane assembly involved in embryonic body morphogenesis CLASP2 907.322039214128 951.430799247063 863.213279181192 0.907279099924363 -0.140381669671269 0.445882124476467 1 3.92344 3.68193 4.08726 3.0192 GeneID:23122,Genbank:XM_017005964.1,HGNC:HGNC:17078,MIM:605853 cytoplasmic linker associated protein 2 GO:0000226,GO:0000777,GO:0002162,GO:0005737,GO:0005794,GO:0005802,GO:0005815,GO:0005828,GO:0005829,GO:0005874,GO:0005881,GO:0005886,GO:0005938,GO:0006903,GO:0007020,GO:0007026,GO:0007030,GO:0007052,GO:0007062,GO:0007163,GO:0008017,GO:0010458,GO:0010470,GO:0010634,GO:0010717,GO:0016020,GO:0030516,GO:0031023,GO:0031110,GO:0031113,GO:0031252,GO:0032587,GO:0032886,GO:0032956,GO:0034453,GO:0035791,GO:0044295,GO:0045180,GO:0045921,GO:0051010,GO:0051015,GO:0051301,GO:0051497,GO:0051895,GO:0072659,GO:0090091,GO:1903690,GO:1903754,GO:1904261,GO:1990782 microtubule cytoskeleton organization|condensed chromosome kinetochore|dystroglycan binding|cytoplasm|Golgi apparatus|trans-Golgi network|microtubule organizing center|kinetochore microtubule|cytosol|microtubule|cytoplasmic microtubule|plasma membrane|cell cortex|vesicle targeting|microtubule nucleation|negative regulation of microtubule depolymerization|Golgi organization|mitotic spindle organization|sister chromatid cohesion|establishment or maintenance of cell polarity|microtubule binding|exit from mitosis|regulation of gastrulation|positive regulation of epithelial cell migration|regulation of epithelial to mesenchymal transition|membrane|regulation of axon extension|microtubule organizing center organization|regulation of microtubule polymerization or depolymerization|regulation of microtubule polymerization|cell leading edge|ruffle membrane|regulation of microtubule-based process|regulation of actin cytoskeleton organization|microtubule anchoring|platelet-derived growth factor receptor-beta signaling pathway|axonal growth cone|basal cortex|positive regulation of exocytosis|microtubule plus-end binding|actin filament binding|cell division|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly|protein localization to plasma membrane|positive regulation of extracellular matrix disassembly|negative regulation of wound healing, spreading of epidermal cells|cortical microtubule plus-end|positive regulation of basement membrane assembly involved in embryonic body morphogenesis|protein tyrosine kinase binding CLASRP 774.922585429152 800.628162617416 749.217008240887 0.935786477697143 -0.0957487132720885 0.533515319180828 1 10.0837 10.0745 9.39094 9.25737 GeneID:11129,Genbank:NM_007056.2,HGNC:HGNC:17731 CLK4 associating serine/arginine rich protein GO:0005634,GO:0005654,GO:0006397,GO:0008380 nucleus|nucleoplasm|mRNA processing|RNA splicing CLBA1 119.700212257064 117.278918545263 122.121505968865 1.0412912012122 0.0583735804489758 0.872738311340283 1 0.578584 0.890146 0.765653 0.798257 GeneID:122616,Genbank:XM_005267318.4,HGNC:HGNC:20126 clathrin binding box of aftiphilin containing 1 CLCA2 2.02101386303638 2.10436443188427 1.93766329418849 0.920783142325533 -0.119066673999736 1 1 0.0251528 0.00806257 0.00807734 0.0225566 GeneID:9635,Genbank:NM_006536.6,HGNC:HGNC:2016,MIM:604003 chloride channel accessory 2 GO:0004222,GO:0005229,GO:0005254,GO:0005576,GO:0005634,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0007155,GO:0009925,GO:0015276,GO:0030054,GO:0031965,GO:0034220,GO:0046872 metalloendopeptidase activity|intracellular calcium activated chloride channel activity|chloride channel activity|extracellular region|nucleus|cytosol|plasma membrane|integral component of plasma membrane|transport|cell adhesion|basal plasma membrane|ligand-gated ion channel activity|cell junction|nuclear membrane|ion transmembrane transport|metal ion binding hsa04924,hsa04972 Renin secretion|Pancreatic secretion CLCC1 1076.11218790738 1150.9632440803 1001.26113173447 0.869933194551791 -0.201023479660971 0.190299852927606 1 9.12113 8.77459 8.18351 7.26028 GeneID:23155,Genbank:NM_001048210.2,HGNC:HGNC:29675,MIM:617539 chloride channel CLIC like 1 GO:0005254,GO:0005634,GO:0005783,GO:0005794,GO:0016020,GO:0034707,GO:0043231 chloride channel activity|nucleus|endoplasmic reticulum|Golgi apparatus|membrane|chloride channel complex|intracellular membrane-bounded organelle CLCF1 511.24344867097 567.444487183393 455.042410158547 0.801915289400779 -0.31847824974845 0.0644693300310493 0.90091963811897 11.6941 11.9064 9.20966 9.98819 GeneID:23529,Genbank:NM_001166212.1,HGNC:HGNC:17412,MIM:607672 cardiotrophin like cytokine factor 1 GO:0002639,GO:0005102,GO:0005125,GO:0005127,GO:0005576,GO:0005622,GO:0007166,GO:0007259,GO:0008083,GO:0008284,GO:0019221,GO:0030183,GO:0030890,GO:0042531,GO:0043524,GO:0046982,GO:0048295,GO:0048711,GO:0070062,GO:0097058,GO:0097059 positive regulation of immunoglobulin production|receptor binding|cytokine activity|ciliary neurotrophic factor receptor binding|extracellular region|intracellular|cell surface receptor signaling pathway|JAK-STAT cascade|growth factor activity|positive regulation of cell proliferation|cytokine-mediated signaling pathway|B cell differentiation|positive regulation of B cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of neuron apoptotic process|protein heterodimerization activity|positive regulation of isotype switching to IgE isotypes|positive regulation of astrocyte differentiation|extracellular exosome|CRLF-CLCF1 complex|CNTFR-CLCF1 complex hsa04060 Cytokine-cytokine receptor interaction CLCN1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:1180,Genbank:NM_000083.2,HGNC:HGNC:2019,MIM:118425 chloride voltage-gated channel 1 GO:0005247,GO:0005886,GO:0005887,GO:0006936,GO:0019227,GO:0034220,GO:0034707,GO:0034765,GO:0042383,GO:0042803,GO:1902476 voltage-gated chloride channel activity|plasma membrane|integral component of plasma membrane|muscle contraction|neuronal action potential propagation|ion transmembrane transport|chloride channel complex|regulation of ion transmembrane transport|sarcolemma|protein homodimerization activity|chloride transmembrane transport CLCN2 191.457308962155 200.204812678825 182.709805245485 0.912614451175024 -0.131922595965211 0.578907577977238 1 1.25394 1.13965 1.26688 1.17362 GeneID:1181,Genbank:NM_001171088.2,HGNC:HGNC:2020,MIM:600570 chloride voltage-gated channel 2 GO:0005247,GO:0005886,GO:0006810,GO:0034220,GO:0034707,GO:0034765,GO:0060041,GO:0060689,GO:1902476 voltage-gated chloride channel activity|plasma membrane|transport|ion transmembrane transport|chloride channel complex|regulation of ion transmembrane transport|retina development in camera-type eye|cell differentiation involved in salivary gland development|chloride transmembrane transport hsa04978 Mineral absorption CLCN3 1404.17419785419 1402.33536231483 1406.01303339356 1.00262253322391 0.00377856313582927 0.956001027650649 1 8.14781 7.4256 8.73448 7.06056 GeneID:1182,Genbank:NM_173872.3,HGNC:HGNC:2021,MIM:600580 chloride voltage-gated channel 3 GO:0000139,GO:0005247,GO:0005254,GO:0005524,GO:0005769,GO:0005770,GO:0005794,GO:0005886,GO:0005887,GO:0006810,GO:0006885,GO:0008021,GO:0009897,GO:0009986,GO:0012506,GO:0015297,GO:0016020,GO:0016021,GO:0030141,GO:0030165,GO:0030658,GO:0031410,GO:0031901,GO:0031902,GO:0042581,GO:0042803,GO:0045335,GO:0045794,GO:0046982,GO:0048388,GO:0072320,GO:1902476 Golgi membrane|voltage-gated chloride channel activity|chloride channel activity|ATP binding|early endosome|late endosome|Golgi apparatus|plasma membrane|integral component of plasma membrane|transport|regulation of pH|synaptic vesicle|external side of plasma membrane|cell surface|vesicle membrane|antiporter activity|membrane|integral component of membrane|secretory granule|PDZ domain binding|transport vesicle membrane|cytoplasmic vesicle|early endosome membrane|late endosome membrane|specific granule|protein homodimerization activity|phagocytic vesicle|negative regulation of cell volume|protein heterodimerization activity|endosomal lumen acidification|volume-sensitive chloride channel activity|chloride transmembrane transport CLCN4 63.5443214726099 53.9068372144551 73.1818057307647 1.35756073834621 0.441016746796188 0.226273805435072 1 0.352397 0.319337 0.499922 0.440845 GeneID:1183,Genbank:NM_001830.3,HGNC:HGNC:2022,MIM:302910 chloride voltage-gated channel 4 GO:0005247,GO:0005254,GO:0005524,GO:0005789,GO:0005887,GO:0006810,GO:0006821,GO:0010008,GO:0015297,GO:0031901,GO:0031902,GO:0034220 voltage-gated chloride channel activity|chloride channel activity|ATP binding|endoplasmic reticulum membrane|integral component of plasma membrane|transport|chloride transport|endosome membrane|antiporter activity|early endosome membrane|late endosome membrane|ion transmembrane transport CLCN5 128.339527384525 128.713239923698 127.965814845353 0.994193098714722 -0.00840200617594565 1 1 0.504032 0.474315 0.654414 0.38375 GeneID:1184,Genbank:NM_001127899.3,HGNC:HGNC:2023,MIM:300008 chloride voltage-gated channel 5 GO:0000139,GO:0005247,GO:0005254,GO:0005524,GO:0005765,GO:0005768,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0007588,GO:0010008,GO:0015297,GO:0016020,GO:0034220,GO:0042802,GO:0045177 Golgi membrane|voltage-gated chloride channel activity|chloride channel activity|ATP binding|lysosomal membrane|endosome|Golgi apparatus|cytosol|plasma membrane|integral component of plasma membrane|transport|excretion|endosome membrane|antiporter activity|membrane|ion transmembrane transport|identical protein binding|apical part of cell CLCN6 539.269596207565 529.402231275205 549.136961139924 1.03727738324257 0.0528017436369446 0.775841075833551 1 3.34316 3.43624 4.04621 2.96591 GeneID:1185,Genbank:NM_001286.3,HGNC:HGNC:2024,MIM:602726 chloride voltage-gated channel 6 GO:0005247,GO:0005524,GO:0005765,GO:0006821,GO:0006884,GO:0007165,GO:0009612,GO:0010008,GO:0015297,GO:0016021,GO:0034220,GO:1902476 voltage-gated chloride channel activity|ATP binding|lysosomal membrane|chloride transport|cell volume homeostasis|signal transduction|response to mechanical stimulus|endosome membrane|antiporter activity|integral component of membrane|ion transmembrane transport|chloride transmembrane transport CLCN7 2012.52204359922 1728.84534353056 2296.19874366789 1.32816897258069 0.409438701200418 0.00388538452576188 0.241195033196133 14.8943 15.6642 21.8851 20.1713 GeneID:1186,Genbank:NM_001114331.2,HGNC:HGNC:2025,MIM:602727 chloride voltage-gated channel 7 GO:0005247,GO:0005254,GO:0005524,GO:0005654,GO:0005765,GO:0006810,GO:0009268,GO:0015297,GO:0016020,GO:0016021,GO:0031410,GO:0034220 voltage-gated chloride channel activity|chloride channel activity|ATP binding|nucleoplasm|lysosomal membrane|transport|response to pH|antiporter activity|membrane|integral component of membrane|cytoplasmic vesicle|ion transmembrane transport CLCNKA 1.72588532371436 1.02816907859967 2.42360156882906 2.35720137793866 1.23707501465219 0.731188896846623 1 0 0.0175608 0.0559193 0 GeneID:1187,Genbank:NM_004070.3,HGNC:HGNC:2026,MIM:602024 chloride voltage-gated channel Ka GO:0005247,GO:0005886,GO:0005887,GO:0006810,GO:0007588,GO:0034220,GO:0034707,GO:0034765,GO:0042802,GO:0046872,GO:1902476 voltage-gated chloride channel activity|plasma membrane|integral component of plasma membrane|transport|excretion|ion transmembrane transport|chloride channel complex|regulation of ion transmembrane transport|identical protein binding|metal ion binding|chloride transmembrane transport CLDN1 317.935791407394 378.038828656136 257.832754158651 0.682027174497401 -0.552098872160492 0.0326044540080169 0.714141733165715 6.17257 4.84148 3.91932 3.58055 GeneID:9076,Genbank:NM_021101.4,HGNC:HGNC:2032,MIM:603718 claudin 1 GO:0001618,GO:0005198,GO:0005737,GO:0005887,GO:0005923,GO:0007568,GO:0008065,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0016338,GO:0032496,GO:0042538,GO:0042802,GO:0045216,GO:0045471,GO:0051260,GO:0051291,GO:0061436,GO:0061772,GO:0070673,GO:0070830,GO:0071284,GO:0071346,GO:0071356,GO:0071548,GO:0071560,GO:0090557,GO:0097421,GO:1903348,GO:1903545 virus receptor activity|structural molecule activity|cytoplasm|integral component of plasma membrane|bicellular tight junction|aging|establishment of blood-nerve barrier|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|response to lipopolysaccharide|hyperosmotic salinity response|identical protein binding|cell-cell junction organization|response to ethanol|protein homooligomerization|protein heterooligomerization|establishment of skin barrier|drug transport across blood-nerve barrier|response to interleukin-18|bicellular tight junction assembly|cellular response to lead ion|cellular response to interferon-gamma|cellular response to tumor necrosis factor|response to dexamethasone|cellular response to transforming growth factor beta stimulus|establishment of endothelial intestinal barrier|liver regeneration|positive regulation of bicellular tight junction assembly|cellular response to butyrate hsa04514,hsa04530,hsa04670,hsa05130,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C CLDN11 5.27645082412825 8.12930007942745 2.42360156882906 0.298131640504007 -1.74597859920987 0.201410755521464 1 0.126574 0.136659 0.0604205 0.0374506 GeneID:5010,Genbank:NM_005602.5,HGNC:HGNC:8514,MIM:601326 claudin 11 GO:0005198,GO:0005886,GO:0005923,GO:0007283,GO:0008366,GO:0016021,GO:0016338,GO:0042802,GO:0043209,GO:0045178,GO:0070062 structural molecule activity|plasma membrane|bicellular tight junction|spermatogenesis|axon ensheathment|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding|myelin sheath|basal part of cell|extracellular exosome hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN12 551.157549187716 714.144256153749 388.170842221683 0.543546823876034 -0.879523773224465 6.24205435724505e-05 0.0184954253916009 9.37072 8.28102 4.72302 4.99482 GeneID:9069,Genbank:NM_001185073.2,HGNC:HGNC:2034,MIM:611232 claudin 12 GO:0005198,GO:0005886,GO:0005923,GO:0016021,GO:0016328,GO:0016338,GO:0042802 structural molecule activity|plasma membrane|bicellular tight junction|integral component of membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding CLDN15 199.108012113207 192.748897445842 205.467126780572 1.06598340900136 0.0921849841217332 0.796140004933962 1 2.6745 3.48494 3.27814 3.68389 GeneID:24146,Genbank:NM_001185080.1,HGNC:HGNC:2036,MIM:615778 claudin 15 GO:0005198,GO:0005923,GO:0006811,GO:0016021,GO:0016328,GO:0016338,GO:0042802 structural molecule activity|bicellular tight junction|ion transport|integral component of membrane|lateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN16 4.6993307120329 4.06465003971372 5.33401138435208 1.31229289907767 0.392089760265395 0.860379968962256 1 0.0470743 0.0299755 0.0901557 0.0280758 GeneID:10686,Genbank:NM_006580.3,HGNC:HGNC:2037,MIM:603959 claudin 16 GO:0005198,GO:0005886,GO:0005923,GO:0006875,GO:0007588,GO:0015095,GO:0016021,GO:0016338,GO:0042802 structural molecule activity|plasma membrane|bicellular tight junction|cellular metal ion homeostasis|excretion|magnesium ion transmembrane transporter activity|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN18 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0104545 GeneID:51208,Genbank:NM_001002026.2,HGNC:HGNC:2039,MIM:609210 claudin 18 GO:0005198,GO:0005886,GO:0005923,GO:0016021,GO:0016338,GO:0042802,GO:0045471,GO:0045779,GO:0048565,GO:0071847,GO:1900181,GO:2001205 structural molecule activity|plasma membrane|bicellular tight junction|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding|response to ethanol|negative regulation of bone resorption|digestive tract development|TNFSF11-mediated signaling pathway|negative regulation of protein localization to nucleus|negative regulation of osteoclast development hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN2 4.29043494878994 5.18887166768327 3.3919982298966 0.653706325215605 -0.613285438230915 0.749847901287099 1 0.0617849 0.0447068 0.0348587 0.043498 GeneID:9075,Genbank:NM_001171092.1,HGNC:HGNC:2041,MIM:300520 claudin 2 GO:0005198,GO:0005886,GO:0005923,GO:0016021,GO:0016338,GO:0042802,GO:0070062 structural molecule activity|plasma membrane|bicellular tight junction|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding|extracellular exosome hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN20 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0314639 0 GeneID:49861,Genbank:NM_001001346.3,HGNC:HGNC:2042 claudin 20 GO:0005198,GO:0005886,GO:0005923,GO:0016021,GO:0016338,GO:0042802 structural molecule activity|plasma membrane|bicellular tight junction|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN22 2.29256425104263 3.13253351048394 1.45259499160132 0.463712514723237 -1.10869743204054 0.696617135597472 1 0.0325709 0.0311404 0 0.0146376 GeneID:53842,Genbank:NM_001111319.1,HGNC:HGNC:2044 claudin 22 GO:0005198,GO:0005886,GO:0005923,GO:0016021,GO:0016338,GO:0042802 structural molecule activity|plasma membrane|bicellular tight junction|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN23 1.22017540552321 1.47021420587209 0.97013660517434 0.65986072049881 -0.59976655382621 0.974348449198545 1 0 0.0588952 0.0628617 0 GeneID:137075,Genbank:NM_194284.2,HGNC:HGNC:17591,MIM:609203 claudin 23 GO:0005198,GO:0005886,GO:0005923,GO:0016021,GO:0016338,GO:0042802 structural molecule activity|plasma membrane|bicellular tight junction|integral component of membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|identical protein binding hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN4 70.6537550300427 107.381437956746 33.9260721033398 0.315939819291725 -1.66227831711123 2.89271772315999e-06 0.00185319068216522 3.40914 3.53583 1.25092 1.04048 GeneID:1364,Genbank:NM_001305.4,HGNC:HGNC:2046,MIM:602909 claudin 4 hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN5 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0178721 0 GeneID:7122,Genbank:NM_003277.3,HGNC:HGNC:2047,MIM:602101 claudin 5 GO:0003151,GO:0005198,GO:0005886,GO:0005911,GO:0005923,GO:0007043,GO:0007179,GO:0007612,GO:0016021,GO:0016327,GO:0016338,GO:0030054,GO:0042802,GO:0060021,GO:0060325,GO:0070062,GO:1903142,GO:2000810 outflow tract morphogenesis|structural molecule activity|plasma membrane|cell-cell junction|bicellular tight junction|cell-cell junction assembly|transforming growth factor beta receptor signaling pathway|learning|integral component of membrane|apicolateral plasma membrane|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|cell junction|identical protein binding|palate development|face morphogenesis|extracellular exosome|positive regulation of establishment of endothelial barrier|regulation of bicellular tight junction assembly hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN6 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0443332 0.041242 GeneID:9074,Genbank:NM_021195.4,HGNC:HGNC:2048,MIM:615798 claudin 6 hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN7 5.77715764294921 6.7071121482403 4.84720313765811 0.722696002471024 -0.468539180707685 0.768381730841074 1 0.185503 0.161099 0.143877 0.106973 GeneID:1366,Genbank:NM_001185022.1,HGNC:HGNC:2049,MIM:609131 claudin 7 hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDN9 4.01801458873029 4.16070258908361 3.87532658837698 0.931411583837939 -0.102509270017476 1 1 0.111171 0.0235128 0.0509507 0.0955233 GeneID:9080,Genbank:NM_020982.3,HGNC:HGNC:2051,MIM:615799 claudin 9 hsa04514,hsa04530,hsa04670,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Hepatitis C CLDND1 1150.89156171656 1212.80727627544 1088.97584715767 0.897896861653025 -0.15537835785779 0.308026843308286 1 22.698 21.0617 20.8359 19.6066 GeneID:56650,Genbank:NM_001040200.1,HGNC:HGNC:1322 claudin domain containing 1 GO:0009986,GO:0016021 cell surface|integral component of membrane CLDND2 18.1626196749587 16.940776659552 19.3844626903655 1.14424876025005 0.194400728834299 0.806741289441321 1 0.290886 0.267357 0.340345 0.318811 GeneID:125875,Genbank:XM_017026245.1,HGNC:HGNC:28511 claudin domain containing 2 GO:0016021 integral component of membrane CLEC11A 69.1064524161427 67.4651403349905 70.7477644972949 1.04865659725904 0.0685423170564185 0.851407943478043 1 3.10678 2.51312 2.69234 3.31587 GeneID:6320,Genbank:NM_002975.2,HGNC:HGNC:10576,MIM:604713 C-type lectin domain containing 11A CLEC12B 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0102105 0 GeneID:387837,Genbank:XM_011520663.2,HGNC:HGNC:31966,MIM:617573 C-type lectin domain family 12 member B GO:0002769,GO:0009897,GO:0016021,GO:0019903,GO:0030246,GO:0030547,GO:0043234,GO:0045953,GO:2000272 natural killer cell inhibitory signaling pathway|external side of plasma membrane|integral component of membrane|protein phosphatase binding|carbohydrate binding|receptor inhibitor activity|protein complex|negative regulation of natural killer cell mediated cytotoxicity|negative regulation of receptor activity CLEC14A 2.67157380551953 0.980142803914724 4.36300480712434 4.4513970716291 2.15425819719991 0.349854367142455 1 0 0.0434173 0.137245 0.0640569 GeneID:161198,Genbank:NM_175060.2,HGNC:HGNC:19832,MIM:616845 C-type lectin domain containing 14A GO:0009897,GO:0016021,GO:0030246,GO:0031012,GO:0070062,GO:1990430 external side of plasma membrane|integral component of membrane|carbohydrate binding|extracellular matrix|extracellular exosome|extracellular matrix protein binding CLEC16A 794.430572361359 775.124832405417 813.736312317301 1.04981324078092 0.0701326987829796 0.661169107318219 1 1.91951 1.88067 2.1783 1.93822 GeneID:23274,Genbank:NM_015226.2,HGNC:HGNC:29013,MIM:611303 C-type lectin domain containing 16A GO:0005794,GO:0005829,GO:0006914,GO:0009267,GO:0031982,GO:0032435,GO:0036020,GO:1901097,GO:1901098,GO:1901525,GO:1904263,GO:1904766 Golgi apparatus|cytosol|autophagy|cellular response to starvation|vesicle|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|endolysosome membrane|negative regulation of autophagosome maturation|positive regulation of autophagosome maturation|negative regulation of mitophagy|positive regulation of TORC1 signaling|negative regulation of macroautophagy by TORC1 signaling CLEC17A 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00771208 0 GeneID:388512,Genbank:XM_017026788.2,HGNC:HGNC:34520,MIM:616838 C-type lectin domain containing 17A GO:0005537,GO:0009986,GO:0016021,GO:0042806,GO:0046872 mannose binding|cell surface|integral component of membrane|fucose binding|metal ion binding CLEC18A 1.2383154714421 0.538097676642304 1.93853326624189 3.60256761994999 1.84902550994227 0.680597935457111 1 0.00821668 0 0.0154024 0.0143746 GeneID:348174,Genbank:XM_017023208.2,HGNC:HGNC:30388,MIM:616571 C-type lectin domain family 18 member A GO:0005615,GO:0005768,GO:0005783,GO:0005794,GO:0030247 extracellular space|endosome|endoplasmic reticulum|Golgi apparatus|polysaccharide binding CLEC18B 1.72838687339946 1.51824048055703 1.93853326624189 1.27682886279692 0.352565169253837 1 1 0.0216129 0.0371728 0.0199874 0.0186839 GeneID:497190,Genbank:XM_017023255.1,HGNC:HGNC:33849,MIM:616572 C-type lectin domain family 18 member B GO:0005576,GO:0005768,GO:0005794,GO:0016529,GO:0030246 extracellular region|endosome|Golgi apparatus|sarcoplasmic reticulum|carbohydrate binding CLEC1A 2.26354801432997 2.10436443188427 2.42273159677566 1.15128898781392 0.203250013275037 1 1 0.0307056 0.014491 0.0292916 0.0408337 GeneID:51267,Genbank:XM_011520687.2,HGNC:HGNC:24355,MIM:606782 C-type lectin domain family 1 member A GO:0004888,GO:0005622,GO:0005887,GO:0006952,GO:0007166,GO:0030246 transmembrane signaling receptor activity|intracellular|integral component of plasma membrane|defense response|cell surface receptor signaling pathway|carbohydrate binding CLEC2B 406.385860345385 403.234383909809 409.53733678096 1.01563099061652 0.0223763226725171 0.893419937929001 1 6.59723 6.35303 7.38259 5.80149 GeneID:9976,Genbank:NM_005127.2,HGNC:HGNC:2053,MIM:603242 C-type lectin domain family 2 member B hsa05167 Kaposi sarcoma-associated herpesvirus infection CLEC2D 89.238713970104 95.609915654661 82.8675122855469 0.866725085135112 -0.206353634550854 0.541985380531825 1 0.648784 0.495629 0.450007 0.493681 GeneID:29121,Genbank:NM_001004419.4,HGNC:HGNC:14351,MIM:605659 C-type lectin domain family 2 member D CLEC3B 1.70187218637189 0.980142803914724 2.42360156882906 2.47270250737863 1.30608867848779 0.73299311284869 1 0 0.0225778 0.0236561 0.0441802 GeneID:7123,Genbank:XM_017007116.1,HGNC:HGNC:11891,MIM:187520 C-type lectin domain family 3 member B CLEC4A 4.15448999191361 2.00831188251439 6.30066810131283 3.13729563429383 1.64952148392602 0.318175466594687 1 0 0.0353748 0.082669 0.0219031 GeneID:50856,Genbank:XM_024448997.1,HGNC:HGNC:13257,MIM:605306 C-type lectin domain family 4 member A CLEC4M 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.019112 GeneID:10332,Genbank:XM_006722613.3,HGNC:HGNC:13523,MIM:605872 C-type lectin domain family 4 member M GO:0001618,GO:0002250,GO:0005537,GO:0006897,GO:0016021,GO:0045087,GO:0046872,GO:0048306 virus receptor activity|adaptive immune response|mannose binding|endocytosis|integral component of membrane|innate immune response|metal ion binding|calcium-dependent protein binding hsa04145,hsa04625,hsa05152,hsa05162 Phagosome|C-type lectin receptor signaling pathway|Tuberculosis|Measles CLEC7A 31.9313780700312 29.9227644838681 33.9399916561942 1.13425320960875 0.181742742104417 0.871378589231671 1 0.309638 0.420591 0.65533 0.20398 GeneID:64581,Genbank:NM_197950.2,HGNC:HGNC:14558,MIM:606264 C-type lectin domain containing 7A GO:0002223,GO:0005654,GO:0005737,GO:0005886,GO:0006910,GO:0006954,GO:0008037,GO:0008329,GO:0009756,GO:0016021,GO:0030246,GO:0042110,GO:0042287,GO:0042832,GO:0043231,GO:0045087,GO:0046872 stimulatory C-type lectin receptor signaling pathway|nucleoplasm|cytoplasm|plasma membrane|phagocytosis, recognition|inflammatory response|cell recognition|signaling pattern recognition receptor activity|carbohydrate mediated signaling|integral component of membrane|carbohydrate binding|T cell activation|MHC protein binding|defense response to protozoan|intracellular membrane-bounded organelle|innate immune response|metal ion binding hsa04145,hsa04625,hsa05152 Phagosome|C-type lectin receptor signaling pathway|Tuberculosis CLGN 415.892665090359 429.495308860804 402.290021319915 0.936657544379125 -0.0944064208903481 0.753687784648301 1 4.58886 3.86978 4.43337 3.31052 GeneID:1047,Genbank:NM_004362.2,HGNC:HGNC:2060,MIM:601858 calmegin GO:0005509,GO:0005635,GO:0005783,GO:0005789,GO:0006461,GO:0007338,GO:0007339,GO:0016021,GO:0044183,GO:0051082 calcium ion binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|protein complex assembly|single fertilization|binding of sperm to zona pellucida|integral component of membrane|protein binding involved in protein folding|unfolded protein binding CLHC1 27.4011191780504 27.6645125728211 27.1377257832796 0.980958031045917 -0.027736680866038 0.994790059693414 1 0.114989 0.0920164 0.104753 0.103868 GeneID:130162,Genbank:NM_001135598.1,HGNC:HGNC:26453 clathrin heavy chain linker domain containing 1 CLIC1 14129.6886653605 14172.6489120128 14086.7284187082 0.993937584015663 -0.00877283671987153 0.933751875176344 1 272.745 281.347 262.301 289.696 GeneID:1192,Genbank:NM_001287593.1,HGNC:HGNC:2062,MIM:602872 chloride intracellular channel 1 CLIC2 16.8506332138575 15.7685287568975 17.9327376708175 1.13724862650698 0.185547692239798 0.843465765472786 1 0.156837 0.209365 0.234883 0.102747 GeneID:1193,Genbank:NM_001289.5,HGNC:HGNC:2063,MIM:300138 chloride intracellular channel 2 GO:0004602,GO:0005244,GO:0005254,GO:0005622,GO:0005634,GO:0005737,GO:0006810,GO:0007165,GO:0010880,GO:0010881,GO:0034707,GO:0051099,GO:0060315,GO:1902476 glutathione peroxidase activity|voltage-gated ion channel activity|chloride channel activity|intracellular|nucleus|cytoplasm|transport|signal transduction|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|chloride channel complex|positive regulation of binding|negative regulation of ryanodine-sensitive calcium-release channel activity|chloride transmembrane transport CLIC3 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:9022,Genbank:NM_004669.2,HGNC:HGNC:2064,MIM:606533 chloride intracellular channel 3 GO:0005244,GO:0005254,GO:0005634,GO:0005737,GO:0006821,GO:0007165,GO:0016604,GO:0034707,GO:0034765,GO:0070062 voltage-gated ion channel activity|chloride channel activity|nucleus|cytoplasm|chloride transport|signal transduction|nuclear body|chloride channel complex|regulation of ion transmembrane transport|extracellular exosome CLIC4 5814.50678687953 6398.74294490383 5230.27062885523 0.817390333365523 -0.290902913050795 0.0463844902114404 0.79332376136203 70.7896 63.5882 58.1836 51.9406 GeneID:25932,Genbank:NM_013943.2,HGNC:HGNC:13518,MIM:606536 chloride intracellular channel 4 CLIC5 3.22011266692892 4.01662376502878 2.42360156882906 0.603392727476851 -0.728830786696267 0.7314041986138 1 0.00997863 0.0139894 0.0142534 0.00443425 GeneID:53405,Genbank:NM_001114086.1,HGNC:HGNC:13517,MIM:607293 chloride intracellular channel 5 GO:0005244,GO:0005254,GO:0005737,GO:0005794,GO:0005815,GO:0005938,GO:0006810,GO:0006821,GO:0007565,GO:0007605,GO:0015629,GO:0034707,GO:0034765,GO:0060088,GO:0070062,GO:1902476 voltage-gated ion channel activity|chloride channel activity|cytoplasm|Golgi apparatus|microtubule organizing center|cell cortex|transport|chloride transport|female pregnancy|sensory perception of sound|actin cytoskeleton|chloride channel complex|regulation of ion transmembrane transport|auditory receptor cell stereocilium organization|extracellular exosome|chloride transmembrane transport CLINT1 1916.38839363148 2008.94632703438 1823.83046022859 0.90785424960603 -0.139467394561404 0.36050578445584 1 16.4573 15.5051 16.3753 12.7333 GeneID:9685,Genbank:NM_001195556.1,HGNC:HGNC:23186,MIM:607265 clathrin interactor 1 GO:0005654,GO:0005794,GO:0005829,GO:0006897,GO:0008289,GO:0016020,GO:0030136,GO:0030276,GO:0043231,GO:0045296,GO:0048268,GO:0048471 nucleoplasm|Golgi apparatus|cytosol|endocytosis|lipid binding|membrane|clathrin-coated vesicle|clathrin binding|intracellular membrane-bounded organelle|cadherin binding|clathrin coat assembly|perinuclear region of cytoplasm CLIP1 858.012686049771 823.696685126425 892.328686973117 1.0833219352293 0.115462038274083 0.66867470306348 1 3.79495 3.00583 4.42087 3.11699 GeneID:6249,Genbank:XM_017019790.1,HGNC:HGNC:10461,MIM:179838 CAP-Gly domain containing linker protein 1 GO:0000278,GO:0000776,GO:0001578,GO:0001726,GO:0005635,GO:0005768,GO:0005813,GO:0005829,GO:0005874,GO:0005881,GO:0005882,GO:0007062,GO:0008017,GO:0008270,GO:0015630,GO:0015631,GO:0030659,GO:0031116,GO:0035371,GO:0042802,GO:0042803,GO:0044861,GO:0046872,GO:0051010 mitotic cell cycle|kinetochore|microtubule bundle formation|ruffle|nuclear envelope|endosome|centrosome|cytosol|microtubule|cytoplasmic microtubule|intermediate filament|sister chromatid cohesion|microtubule binding|zinc ion binding|microtubule cytoskeleton|tubulin binding|cytoplasmic vesicle membrane|positive regulation of microtubule polymerization|microtubule plus-end|identical protein binding|protein homodimerization activity|protein transport into plasma membrane raft|metal ion binding|microtubule plus-end binding hsa04150 mTOR signaling pathway CLIP2 2475.26663210978 2012.28280830042 2938.25045591915 1.46015780873306 0.546124298949997 8.21010663135014e-05 0.0207690271445571 13.3511 12.8512 19.6391 19.7033 GeneID:7461,Genbank:NM_003388.4,HGNC:HGNC:2586,MIM:603432 CAP-Gly domain containing linker protein 2 GO:0005875,GO:0005881,GO:0008017,GO:0035371,GO:0051010 microtubule associated complex|cytoplasmic microtubule|microtubule binding|microtubule plus-end|microtubule plus-end binding CLIP3 581.496622321691 495.212902997776 667.780341645606 1.3484712082484 0.431324718339777 0.0107132756938321 0.413666579021508 3.63991 3.69558 4.99541 5.40846 GeneID:25999,Genbank:NM_015526.2,HGNC:HGNC:24314,MIM:607382 CAP-Gly domain containing linker protein 3 GO:0001934,GO:0005795,GO:0005802,GO:0005829,GO:0005886,GO:0008017,GO:0010803,GO:0010828,GO:0018230,GO:0031115,GO:0031901,GO:0032588,GO:0035594,GO:0043065,GO:0044091,GO:0045121,GO:0045444,GO:0045807,GO:0055038,GO:0072321,GO:1903078 positive regulation of protein phosphorylation|Golgi stack|trans-Golgi network|cytosol|plasma membrane|microtubule binding|regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of glucose transport|peptidyl-L-cysteine S-palmitoylation|negative regulation of microtubule polymerization|early endosome membrane|trans-Golgi network membrane|ganglioside binding|positive regulation of apoptotic process|membrane biogenesis|membrane raft|fat cell differentiation|positive regulation of endocytosis|recycling endosome membrane|chaperone-mediated protein transport|positive regulation of protein localization to plasma membrane CLIP4 785.860951138348 799.098079480042 772.623822796653 0.966869828168509 -0.0486064253476412 0.882448882696772 1 5.15554 4.67389 5.66681 3.84359 GeneID:79745,Genbank:NM_001287528.1,HGNC:HGNC:26108 CAP-Gly domain containing linker protein family member 4 GO:0043231 intracellular membrane-bounded organelle CLK1 209.799889534154 225.755152164654 193.844626903655 0.85864984716838 -0.219858166947694 0.338275722766473 1 2.70425 2.61995 2.34128 2.36139 GeneID:1195,Genbank:NM_004071.3,HGNC:HGNC:2068,MIM:601951 CDC like kinase 1 GO:0004674,GO:0004712,GO:0004715,GO:0005524,GO:0005634,GO:0005737,GO:0008283,GO:0018105,GO:0018107,GO:0043484,GO:0046777 protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|cell proliferation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of RNA splicing|protein autophosphorylation hsa05134 Legionellosis CLK2 548.034226059058 579.004287076522 517.064165041593 0.893023033822991 -0.163230707498719 0.332191257554305 1 7.26015 8.11036 7.0655 7.85077 GeneID:1196,Genbank:NM_001294339.1,HGNC:HGNC:2069,MIM:602989 CDC like kinase 2 GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005634,GO:0005654,GO:0006468,GO:0010212,GO:0016604,GO:0016607,GO:0032526,GO:0042802,GO:0043484,GO:0045721,GO:0046777 protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|protein phosphorylation|response to ionizing radiation|nuclear body|nuclear speck|response to retinoic acid|identical protein binding|regulation of RNA splicing|negative regulation of gluconeogenesis|protein autophosphorylation CLK3 1425.27551210524 1333.23936264226 1517.31166156822 1.13806395466839 0.18658163364657 0.205470491789937 1 4.18843 4.23826 4.81056 5.12777 GeneID:1198,Genbank:XM_017021909.1,HGNC:HGNC:2071,MIM:602990 CDC like kinase 3 GO:0001669,GO:0003723,GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005634,GO:0005654,GO:0006468,GO:0016020,GO:0016607,GO:0042802,GO:0043484,GO:0045111,GO:0046777 acrosomal vesicle|RNA binding|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|protein phosphorylation|membrane|nuclear speck|identical protein binding|regulation of RNA splicing|intermediate filament cytoskeleton|protein autophosphorylation CLK4 107.616179018577 114.90499677463 100.327361262525 0.873133145456702 -0.195726425404431 0.520821525965869 1 1.40915 1.30721 1.37517 1.00191 GeneID:57396,Genbank:NM_020666.2,HGNC:HGNC:13659,MIM:607969 CDC like kinase 4 GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005634,GO:0043484,GO:0046777 protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|regulation of RNA splicing|protein autophosphorylation CLMN 87.3512452576621 83.0993989229412 91.603091592383 1.10233157856325 0.140558248224764 0.690748470044948 1 0.183139 0.240834 0.285425 0.238509 GeneID:79789,Genbank:NM_024734.3,HGNC:HGNC:19972,MIM:611121 calmin GO:0003779,GO:0005737,GO:0008285,GO:0016021,GO:0031175 actin binding|cytoplasm|negative regulation of cell proliferation|integral component of membrane|neuron projection development CLMP 178.490230144007 174.250645685301 182.729814602713 1.04866076038952 0.0685480444945442 0.774258190313928 1 2.00953 1.92798 2.35703 1.74817 GeneID:79827,Genbank:NM_024769.3,HGNC:HGNC:24039,MIM:611693 CXADR like membrane protein GO:0005881,GO:0005886,GO:0005923,GO:0009986,GO:0016021,GO:0048565,GO:0070062 cytoplasmic microtubule|plasma membrane|bicellular tight junction|cell surface|integral component of membrane|digestive tract development|extracellular exosome CLN3 1262.26243402154 1166.64756294464 1357.87730509844 1.1639138915879 0.218984329058639 0.146349417484845 1 20.4316 21.8158 24.6959 25.6692 GeneID:1201,Genbank:NM_001286109.1,HGNC:HGNC:2074,MIM:607042 CLN3, battenin hsa04142 Lysosome CLN5 553.396932790283 509.231851554945 597.562014025622 1.17345765431004 0.230765781341962 0.168858061923035 1 7.02665 6.57638 8.40802 7.48501 GeneID:1203,Genbank:NM_006493.2,HGNC:HGNC:2076,MIM:608102 CLN5, intracellular trafficking protein hsa04142 Lysosome CLN6 2504.36810002129 2354.89546819413 2653.84073184845 1.12694629876016 0.172418769850605 0.219763813152798 1 55.4206 57.0742 66.2123 63.5223 GeneID:54982,Genbank:NM_017882.2,HGNC:HGNC:2077,MIM:606725 CLN6, transmembrane ER protein CLN8 884.21964623804 933.453061854658 834.986230621423 0.894513355564346 -0.160825072238342 0.306783859400653 1 4.19096 4.06163 3.65057 3.70008 GeneID:2055,Genbank:XM_005266022.1,HGNC:HGNC:2079,MIM:607837 CLN8, transmembrane ER and ERGIC protein CLNS1A 1008.5049098313 1030.32248630709 986.687333355518 0.957649033645795 -0.0624310716926638 0.683244851554952 1 19.0945 20.77 19.4115 19.5476 GeneID:1207,Genbank:NM_001311202.1,HGNC:HGNC:2080,MIM:602158 chloride nucleotide-sensitive channel 1A GO:0000387,GO:0003723,GO:0005634,GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0006821,GO:0006884,GO:0034709,GO:0034715,GO:0046982 spliceosomal snRNP assembly|RNA binding|nucleus|nucleoplasm|cytosol|cytoskeleton|plasma membrane|chloride transport|cell volume homeostasis|methylosome|pICln-Sm protein complex|protein heterodimerization activity hsa03013 RNA transport CLOCK 608.189517011694 652.164936788805 564.214097234583 0.865140189861658 -0.208994164645953 0.627836765435716 1 2.35367 1.73443 2.23483 1.34711 GeneID:9575,Genbank:NM_004898.3,HGNC:HGNC:2082,MIM:601851 clock circadian regulator GO:0000077,GO:0000978,GO:0000982,GO:0001046,GO:0001047,GO:0001190,GO:0003677,GO:0003700,GO:0004402,GO:0005634,GO:0005654,GO:0005667,GO:0005694,GO:0005829,GO:0006355,GO:0006357,GO:0006473,GO:0007165,GO:0007283,GO:0007623,GO:0009648,GO:0031490,GO:0032922,GO:0033391,GO:0042634,GO:0043161,GO:0043231,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0050729,GO:0050796,GO:0051092,GO:0051775,GO:0070888,GO:0071479,GO:2000074,GO:2000323 DNA damage checkpoint|RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|core promoter sequence-specific DNA binding|core promoter binding|transcriptional activator activity, RNA polymerase II transcription factor binding|DNA binding|DNA binding transcription factor activity|histone acetyltransferase activity|nucleus|nucleoplasm|transcription factor complex|chromosome|cytosol|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|protein acetylation|signal transduction|spermatogenesis|circadian rhythm|photoperiodism|chromatin DNA binding|circadian regulation of gene expression|chromatoid body|regulation of hair cycle|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|positive regulation of inflammatory response|regulation of insulin secretion|positive regulation of NF-kappaB transcription factor activity|response to redox state|E-box binding|cellular response to ionizing radiation|regulation of type B pancreatic cell development|negative regulation of glucocorticoid receptor signaling pathway hsa04710,hsa04728,hsa05168 Circadian rhythm|Dopaminergic synapse|Herpes simplex infection CLP1 465.094437545856 499.844059678601 430.344815413111 0.860958147006534 -0.215984988012889 0.229135928708267 1 11.439 10.6882 9.7515 9.68243 GeneID:10978,Genbank:NM_006831.2,HGNC:HGNC:16999,MIM:608757 cleavage and polyadenylation factor I subunit 1 GO:0000214,GO:0000398,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005849,GO:0006369,GO:0006378,GO:0006379,GO:0006388,GO:0021695,GO:0030423,GO:0031124,GO:0035087,GO:0046404,GO:0051733,GO:0051736 tRNA-intron endonuclease complex|mRNA splicing, via spliceosome|ATP binding|nucleus|nucleoplasm|cytosol|mRNA cleavage factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|tRNA splicing, via endonucleolytic cleavage and ligation|cerebellar cortex development|targeting of mRNA for destruction involved in RNA interference|mRNA 3'-end processing|siRNA loading onto RISC involved in RNA interference|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|polydeoxyribonucleotide kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity hsa03015 mRNA surveillance pathway CLPB 465.528514539324 456.142478010988 474.91455106766 1.0411539682481 0.058183433481404 0.753312733511134 1 3.42967 3.53132 3.86108 3.85599 GeneID:81570,Genbank:NM_001258393.2,HGNC:HGNC:30664,MIM:616254 ClpB homolog, mitochondrial AAA ATPase chaperonin GO:0005524,GO:0005739,GO:0016887,GO:0034605 ATP binding|mitochondrion|ATPase activity|cellular response to heat hsa04213 Longevity regulating pathway - multiple species CLPP 1631.3229865028 1698.83735215329 1563.80862085231 0.920516975253798 -0.119483768327216 0.443644206666497 1 72.5624 80.4276 69.3291 74.2056 GeneID:8192,Genbank:NM_006012.2,HGNC:HGNC:2084,MIM:601119 caseinolytic mitochondrial matrix peptidase proteolytic subunit GO:0004252,GO:0005739,GO:0005759,GO:0008233,GO:0009368,GO:0042802,GO:0051260,GO:0051603 serine-type endopeptidase activity|mitochondrion|mitochondrial matrix|peptidase activity|endopeptidase Clp complex|identical protein binding|protein homooligomerization|proteolysis involved in cellular protein catabolic process CLPSL1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0352043 0 0 GeneID:340204,Genbank:NM_001348773.1,HGNC:HGNC:21251 colipase like 1 GO:0005576,GO:0007586,GO:0008047,GO:0016042,GO:0032094 extracellular region|digestion|enzyme activator activity|lipid catabolic process|response to food CLPTM1 6320.93121439085 6181.80471567701 6460.05771310468 1.04501161234065 0.0635189738594485 0.645749070606518 1 83.7116 86.4591 91.7677 89.0287 GeneID:1209,Genbank:NM_001282176.1,HGNC:HGNC:2087,MIM:604783 CLPTM1, transmembrane protein GO:0005887,GO:0007275,GO:0009897,GO:0016020,GO:0030154,GO:0033081 integral component of plasma membrane|multicellular organism development|external side of plasma membrane|membrane|cell differentiation|regulation of T cell differentiation in thymus CLPTM1L 5195.31133901891 5176.02300008651 5214.59967795131 1.00745295719593 0.0107124739843418 0.953566857053846 1 77.0245 80.4652 82.0542 78.0622 GeneID:81037,Genbank:NM_030782.4,HGNC:HGNC:24308,MIM:612585 CLPTM1 like GO:0006915,GO:0016020,GO:0016021 apoptotic process|membrane|integral component of membrane CLPX 651.866343492031 710.551077206631 593.18160977743 0.834819098592303 -0.260464488724517 0.120149302270016 1 6.29698 5.74034 5.05121 4.93946 GeneID:10845,Genbank:NM_006660.4,HGNC:HGNC:2088,MIM:615611 caseinolytic mitochondrial matrix peptidase chaperone subunit GO:0005524,GO:0005654,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006457,GO:0009368,GO:0009841,GO:0016504,GO:0016887,GO:0042645,GO:0046034,GO:0046872,GO:0051082,GO:0051603 ATP binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|protein folding|endopeptidase Clp complex|mitochondrial endopeptidase Clp complex|peptidase activator activity|ATPase activity|mitochondrial nucleoid|ATP metabolic process|metal ion binding|unfolded protein binding|proteolysis involved in cellular protein catabolic process CLRN1 3.20716993247674 1.56626675524197 4.84807310971151 3.09530486648332 1.63008151208988 0.396701656845747 1 0.014819 0.0140896 0.0708794 0.0264238 GeneID:7401,Genbank:NM_052995.2,HGNC:HGNC:12605,MIM:606397 clarin 1 CLSPN 682.275271954509 741.252070740567 623.298473168451 0.840872488282871 -0.250041051207582 0.152201359174727 1 2.45296 2.34275 2.33311 1.75639 GeneID:63967,Genbank:NM_001330490.1,HGNC:HGNC:19715,MIM:605434 claspin CLSTN1 8674.52892316923 7726.12651439053 9622.93133194793 1.24550527538275 0.316731132178839 0.0162582162834936 0.529251203244782 51.8253 54.6201 69.8662 65.0206 GeneID:22883,Genbank:NM_014944.4,HGNC:HGNC:17447,MIM:611321 calsyntenin 1 GO:0000139,GO:0001540,GO:0001558,GO:0005509,GO:0005634,GO:0005789,GO:0007155,GO:0007156,GO:0009986,GO:0014069,GO:0016021,GO:0019894,GO:0030054,GO:0042988,GO:0042995,GO:0045211,GO:0050806,GO:0051965,GO:0070062 Golgi membrane|amyloid-beta binding|regulation of cell growth|calcium ion binding|nucleus|endoplasmic reticulum membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell surface|postsynaptic density|integral component of membrane|kinesin binding|cell junction|X11-like protein binding|cell projection|postsynaptic membrane|positive regulation of synaptic transmission|positive regulation of synapse assembly|extracellular exosome CLSTN2 36.1394456201639 40.7807705660841 31.4981206742438 0.772376790262016 -0.372623282588683 0.454379297393215 1 0.111836 0.086963 0.0718495 0.0762356 GeneID:64084,Genbank:NM_022131.2,HGNC:HGNC:17448,MIM:611323 calsyntenin 2 GO:0000139,GO:0005509,GO:0005789,GO:0007156,GO:0009986,GO:0014069,GO:0016021,GO:0045211,GO:0050806,GO:0051965 Golgi membrane|calcium ion binding|endoplasmic reticulum membrane|homophilic cell adhesion via plasma membrane adhesion molecules|cell surface|postsynaptic density|integral component of membrane|postsynaptic membrane|positive regulation of synaptic transmission|positive regulation of synapse assembly CLSTN3 376.179209114815 365.625381474641 386.733036754989 1.05773027899545 0.0809717874095103 0.68911100212841 1 2.13038 2.3593 2.49914 2.36566 GeneID:9746,Genbank:NM_014718.3,HGNC:HGNC:18371,MIM:611324 calsyntenin 3 GO:0000139,GO:0001558,GO:0005509,GO:0005789,GO:0007156,GO:0007416,GO:0009986,GO:0014069,GO:0016021,GO:0035249,GO:0043234,GO:0045211,GO:0050806,GO:0051932,GO:0051965,GO:0070062,GO:1902474 Golgi membrane|regulation of cell growth|calcium ion binding|endoplasmic reticulum membrane|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|cell surface|postsynaptic density|integral component of membrane|synaptic transmission, glutamatergic|protein complex|postsynaptic membrane|positive regulation of synaptic transmission|synaptic transmission, GABAergic|positive regulation of synapse assembly|extracellular exosome|positive regulation of protein localization to synapse CLTA 8305.30913987289 8436.73746052866 8173.88081921712 0.968843804546328 -0.0456639994948049 0.709508016021979 1 217.243 234.858 217.302 227.06 GeneID:1211,Genbank:XM_024447409.1,HGNC:HGNC:2090,MIM:118960 clathrin light chain A GO:0005198,GO:0005819,GO:0005829,GO:0005886,GO:0006886,GO:0007018,GO:0007049,GO:0016020,GO:0019886,GO:0030118,GO:0030125,GO:0030130,GO:0030132,GO:0030672,GO:0031410,GO:0032050,GO:0032403,GO:0032588,GO:0032802,GO:0034383,GO:0036020,GO:0042277,GO:0045334,GO:0048268,GO:0051020,GO:0051301,GO:0061024,GO:0071439,GO:0072583 structural molecule activity|spindle|cytosol|plasma membrane|intracellular protein transport|microtubule-based movement|cell cycle|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|clathrin coat|clathrin vesicle coat|clathrin coat of trans-Golgi network vesicle|clathrin coat of coated pit|synaptic vesicle membrane|cytoplasmic vesicle|clathrin heavy chain binding|protein complex binding|trans-Golgi network membrane|low-density lipoprotein particle receptor catabolic process|low-density lipoprotein particle clearance|endolysosome membrane|peptide binding|clathrin-coated endocytic vesicle|clathrin coat assembly|GTPase binding|cell division|membrane organization|clathrin complex|clathrin-dependent endocytosis hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100 Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTB 1740.5673496912 1634.30283157493 1846.83186780747 1.13004262865269 0.176377196521732 0.265750554308819 1 12.482 15.0502 15.3974 16.6796 GeneID:1212,Genbank:NM_001834.3,HGNC:HGNC:2091,MIM:118970 clathrin light chain B GO:0005198,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0030118,GO:0030125,GO:0030130,GO:0030132,GO:0032050,GO:0042277,GO:0043231,GO:0045334,GO:0060170,GO:0061024,GO:0072583 structural molecule activity|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|clathrin coat|clathrin vesicle coat|clathrin coat of trans-Golgi network vesicle|clathrin coat of coated pit|clathrin heavy chain binding|peptide binding|intracellular membrane-bounded organelle|clathrin-coated endocytic vesicle|ciliary membrane|membrane organization|clathrin-dependent endocytosis hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100 Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTC 8861.90444645474 8907.11090379975 8816.69798910973 0.989849355681487 -0.0147191155015195 0.968309542506435 1 40.8495 36.2781 46.6305 31.6807 GeneID:1213,Genbank:NM_001288653.1,HGNC:HGNC:2092,MIM:118955 clathrin heavy chain hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100 Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTCL1 191.388255024286 186.492622079127 196.283887969445 1.05250216218293 0.0738231970611564 0.752444981594201 1 1.02753 0.889279 1.16663 0.927162 GeneID:8218,Genbank:NM_001835.3,HGNC:HGNC:2093,MIM:601273 clathrin heavy chain like 1 hsa04142,hsa04144,hsa04721,hsa04961,hsa05016,hsa05100 Lysosome|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Huntington disease|Bacterial invasion of epithelial cells CLTRN 3.44622419555674 1.56626675524197 5.3261816358715 3.40055844130374 1.76577168587561 0.568404839467001 1 0.020563 0 0 0.183962 GeneID:57393,Genbank:NM_020665.5,HGNC:HGNC:29437,MIM:300631 collectrin, amino acid transport regulator GO:0005737,GO:0008237,GO:0008241,GO:0016021,GO:0031526,GO:0035543,GO:0035774,GO:0045956,GO:0051957,GO:0070062 cytoplasm|metallopeptidase activity|peptidyl-dipeptidase activity|integral component of membrane|brush border membrane|positive regulation of SNARE complex assembly|positive regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of calcium ion-dependent exocytosis|positive regulation of amino acid transport|extracellular exosome CLU 2030.90250861372 1867.02382757061 2194.78118965682 1.17555071191174 0.233336776545595 0.101397411950195 1 21.682 23.5922 26.5508 27.8214 GeneID:1191,Genbank:NM_001831.3,HGNC:HGNC:2095,MIM:185430 clusterin hsa04610 Complement and coagulation cascades CLUAP1 166.133400716179 182.033953186826 150.232848245533 0.82530124526464 -0.277007277684547 0.264312613375486 1 1.31394 1.191 0.942516 1.02445 GeneID:23059,Genbank:NM_001330454.1,HGNC:HGNC:19009,MIM:616787 clusterin associated protein 1 GO:0005654,GO:0005813,GO:0005929,GO:0030992,GO:0035735,GO:0043231,GO:0060271,GO:0097542 nucleoplasm|centrosome|cilium|intraciliary transport particle B|intraciliary transport involved in cilium assembly|intracellular membrane-bounded organelle|cilium assembly|ciliary tip CLUH 3241.1853641206 3276.97204360015 3205.39868464104 0.978158691009009 -0.031859555927102 0.801118429545948 1 19.7765 20.0631 20.8839 19.1203 GeneID:23277,Genbank:NM_015229.3,HGNC:HGNC:29094,MIM:616184 clustered mitochondria homolog GO:0003729,GO:0005737,GO:0007005,GO:0048312 mRNA binding|cytoplasm|mitochondrion organization|intracellular distribution of mitochondria CLUL1 4.01931954681039 4.16070258908361 3.87793650453717 0.932038861588346 -0.101537985231046 1 1 0.021219 0.00673006 0.0338848 0.00630359 GeneID:27098,Genbank:NM_001289036.1,HGNC:HGNC:2096,MIM:616990 clusterin like 1 GO:0005576 extracellular region CLVS1 21.0778287630966 23.7439413571622 18.4117161690309 0.775427966742225 -0.366935326328164 0.585565681021245 1 0.129388 0.130374 0.0744159 0.107666 GeneID:157807,Genbank:XM_024447079.1,HGNC:HGNC:23139,MIM:611292 clavesin 1 GO:0005768,GO:0005802,GO:0007040,GO:0030136,GO:0031901,GO:0032588,GO:0080025 endosome|trans-Golgi network|lysosome organization|clathrin-coated vesicle|early endosome membrane|trans-Golgi network membrane|phosphatidylinositol-3,5-bisphosphate binding CLVS2 6.23440630042871 6.169014471598 6.29979812925943 1.02120008929523 0.0302655690090374 1 1 0.0253484 0.0206804 0.0245785 0.0229086 GeneID:134829,Genbank:NM_001010852.3,HGNC:HGNC:23046,MIM:616945 clavesin 2 GO:0005768,GO:0005802,GO:0007040,GO:0030136,GO:0031901,GO:0032588,GO:0080025 endosome|trans-Golgi network|lysosome organization|clathrin-coated vesicle|early endosome membrane|trans-Golgi network membrane|phosphatidylinositol-3,5-bisphosphate binding CLYBL 81.8121299236255 73.0000045805763 90.6242552666747 1.24142807644135 0.312000679744988 0.336511247592691 1 0.267654 0.196711 0.300803 0.280761 GeneID:171425,Genbank:NM_206808.3,HGNC:HGNC:18355,MIM:609686 citrate lyase beta like GO:0000287,GO:0004474,GO:0005739,GO:0047777,GO:0070207,GO:0106064 magnesium ion binding|malate synthase activity|mitochondrion|(3S)-citramalyl-CoA lyase activity|protein homotrimerization|regulation of cobalamin metabolic process CMAS 1001.13181864363 1051.90422830258 950.359408984684 0.903465718089421 -0.146458235668787 0.339681242604954 1 25.9643 26.8332 25.3549 23.5515 GeneID:55907,Genbank:NM_018686.5,HGNC:HGNC:18290,MIM:603316 cytidine monophosphate N-acetylneuraminic acid synthetase GO:0005634,GO:0005654,GO:0006054,GO:0008781,GO:0016020 nucleus|nucleoplasm|N-acetylneuraminate metabolic process|N-acylneuraminate cytidylyltransferase activity|membrane hsa00520 Amino sugar and nucleotide sugar metabolism CMBL 588.105151787954 550.551736798526 625.658566777382 1.13642102087554 0.184497423046648 0.27990170180423 1 4.81326 5.27414 5.8747 5.57194 GeneID:134147,Genbank:NM_138809.3,HGNC:HGNC:25090,MIM:613379 carboxymethylenebutenolidase homolog GO:0005829,GO:0006805,GO:0016787,GO:0070062 cytosol|xenobiotic metabolic process|hydrolase activity|extracellular exosome CMC1 723.108137474257 767.783570031165 678.432704917349 0.883624932075339 -0.178493969003143 0.268931794777167 1 1.5479 1.51959 1.38419 1.61748 GeneID:152100,Genbank:XM_024453372.1,HGNC:HGNC:28783,MIM:615166 C-X9-C motif containing 1 GO:0005739,GO:0046872 mitochondrion|metal ion binding CMC2 1013.50581712976 997.267188312738 1029.74444594678 1.03256625507653 0.0462343557886603 0.774485615661488 1 15.0135 14.5907 15.4581 17.7171 GeneID:56942,Genbank:NM_020188.4,HGNC:HGNC:24447 C-X9-C motif containing 2 GO:0005739 mitochondrion CMC4 193.871282930494 188.596986511011 199.145579349978 1.05593192677207 0.0785168308384799 0.811295670910449 1 30.2079 27.7248 26.934 31.0376 GeneID:100272147,Genbank:NM_001018024.2,HGNC:HGNC:35428 C-X9-C motif containing 4 CMIP 821.761729536106 747.422102213019 896.101356859193 1.1989227428597 0.261738696213155 0.0982116720488885 1 2.20124 2.2948 2.85015 2.61681 GeneID:80790,Genbank:NM_198390.2,HGNC:HGNC:24319,MIM:610112 c-Maf inducing protein GO:0005654,GO:0005829 nucleoplasm|cytosol CMPK1 2046.91394749479 2178.94900923548 1914.87888575411 0.878808488697024 -0.186379289598233 0.194724153734945 1 37.9506 35.7618 35.5665 29.4718 GeneID:51727,Genbank:NM_016308.2,HGNC:HGNC:18170,MIM:191710 cytidine/uridine monophosphate kinase 1 GO:0004127,GO:0004550,GO:0004849,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006165,GO:0006207,GO:0009041,GO:0009142,GO:0009220,GO:0015949,GO:0050145,GO:0070062 cytidylate kinase activity|nucleoside diphosphate kinase activity|uridine kinase activity|ATP binding|nucleus|nucleolus|cytoplasm|cytosol|nucleoside diphosphate phosphorylation|'de novo' pyrimidine nucleobase biosynthetic process|uridylate kinase activity|nucleoside triphosphate biosynthetic process|pyrimidine ribonucleotide biosynthetic process|nucleobase-containing small molecule interconversion|nucleoside phosphate kinase activity|extracellular exosome hsa00240,hsa00983 Pyrimidine metabolism|Drug metabolism - other enzymes CMPK2 160.524684292112 38.2823872816124 282.766981302611 7.38634660431506 2.88486096259687 0.300525564642709 1 0.440355 0.395132 6.36546 0.342044 GeneID:129607,Genbank:NM_001256478.1,HGNC:HGNC:27015,MIM:611787 cytidine/uridine monophosphate kinase 2 GO:0004127,GO:0004550,GO:0004798,GO:0005524,GO:0005739,GO:0006165,GO:0006227,GO:0006233,GO:0006235,GO:0009142,GO:0033862,GO:0071222 cytidylate kinase activity|nucleoside diphosphate kinase activity|thymidylate kinase activity|ATP binding|mitochondrion|nucleoside diphosphate phosphorylation|dUDP biosynthetic process|dTDP biosynthetic process|dTTP biosynthetic process|nucleoside triphosphate biosynthetic process|UMP kinase activity|cellular response to lipopolysaccharide hsa00240 Pyrimidine metabolism CMSS1 607.750575955761 666.417259066855 549.083892844667 0.823934082399843 -0.279399173496925 0.0959871666909996 1 12.3871 12.0826 10.4658 10.4802 GeneID:84319,Genbank:NM_032359.3,HGNC:HGNC:28666 cms1 ribosomal small subunit homolog (yeast) GO:0003723,GO:0005634,GO:0030686 RNA binding|nucleus|90S preribosome CMTM1 24.0483376157033 26.2903509163189 21.8063243150877 0.829442116786358 -0.269786789702645 0.675618900306196 1 0.968125 0.926802 0.623408 1.16738 GeneID:113540,Genbank:NM_181271.2,HGNC:HGNC:19172,MIM:607884 CKLF like MARVEL transmembrane domain containing 1 GO:0005125,GO:0005615,GO:0006935,GO:0016021 cytokine activity|extracellular space|chemotaxis|integral component of membrane CMTM2 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0431527 0 0 0 GeneID:146225,Genbank:NM_144673.2,HGNC:HGNC:19173,MIM:607885 CKLF like MARVEL transmembrane domain containing 2 GO:0005125,GO:0005615,GO:0006935,GO:0016021 cytokine activity|extracellular space|chemotaxis|integral component of membrane CMTM3 1819.00114187705 1730.99671723628 1907.00556651783 1.10168063724729 0.139706066164234 0.32884662334163 1 30.7119 30.5118 34.8791 33.8918 GeneID:123920,Genbank:XM_006721131.2,HGNC:HGNC:19174,MIM:607886 CKLF like MARVEL transmembrane domain containing 3 GO:0005125,GO:0005615,GO:0005737,GO:0006935,GO:0016021,GO:0031965,GO:0050861 cytokine activity|extracellular space|cytoplasm|chemotaxis|integral component of membrane|nuclear membrane|positive regulation of B cell receptor signaling pathway CMTM4 1621.55499727396 1890.62063910115 1352.48935544677 0.71536792071083 -0.483242669969192 0.000825148495807737 0.0905176596497036 10.243 9.76709 6.77129 7.72736 GeneID:146223,Genbank:XM_017022954.1,HGNC:HGNC:19175,MIM:607887 CKLF like MARVEL transmembrane domain containing 4 GO:0005125,GO:0005615,GO:0006935,GO:0016021 cytokine activity|extracellular space|chemotaxis|integral component of membrane CMTM6 2962.05944369091 2921.18122277996 3002.93766460187 1.02798745972497 0.0398226654044174 0.747545288711735 1 46.5853 43.6358 51.2486 42.4825 GeneID:54918,Genbank:NM_017801.2,HGNC:HGNC:19177,MIM:607889 CKLF like MARVEL transmembrane domain containing 6 GO:0005125,GO:0005886,GO:0006935,GO:0016020,GO:0016021,GO:0035577,GO:0035579,GO:0043312,GO:0070062 cytokine activity|plasma membrane|chemotaxis|membrane|integral component of membrane|azurophil granule membrane|specific granule membrane|neutrophil degranulation|extracellular exosome CMTM7 634.477548896814 680.591112104041 588.363985689587 0.864489669679443 -0.210079370570163 0.201834208658928 1 8.55382 9.05923 8.23198 7.28882 GeneID:112616,Genbank:NM_181472.2,HGNC:HGNC:19178,MIM:607890 CKLF like MARVEL transmembrane domain containing 7 GO:0002337,GO:0005125,GO:0005615,GO:0006935,GO:0016020,GO:0016021 B-1a B cell differentiation|cytokine activity|extracellular space|chemotaxis|membrane|integral component of membrane CMTM8 186.204825648458 212.485006692228 159.924644604689 0.752639666648714 -0.409968768583698 0.0830892423126602 0.963076417285947 4.024 3.32248 2.78445 2.83575 GeneID:152189,Genbank:NM_178868.4,HGNC:HGNC:19179,MIM:607891 CKLF like MARVEL transmembrane domain containing 8 GO:0001766,GO:0005125,GO:0005615,GO:0005654,GO:0005737,GO:0006935,GO:0008104,GO:0016021,GO:0019911,GO:0042552,GO:0045121 membrane raft polarization|cytokine activity|extracellular space|nucleoplasm|cytoplasm|chemotaxis|protein localization|integral component of membrane|structural constituent of myelin sheath|myelination|membrane raft CMTR1 2648.63258278285 2493.35128422633 2803.91388133936 1.12455629460547 0.16935588336144 0.379505002477607 1 19.8059 20.2861 26.6531 19.3911 GeneID:23070,Genbank:NM_015050.2,HGNC:HGNC:21077,MIM:616189 cap methyltransferase 1 GO:0003676,GO:0004483,GO:0005634,GO:0005654,GO:0005829,GO:0006370,GO:0080009,GO:0097309 nucleic acid binding|mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleus|nucleoplasm|cytosol|7-methylguanosine mRNA capping|mRNA methylation|cap1 mRNA methylation CMTR2 202.288111085988 239.303646630082 165.272575541895 0.69063960315396 -0.533995030265069 0.0205788247249176 0.586657016555258 2.61827 2.16149 1.86544 1.44095 GeneID:55783,Genbank:XM_017023444.1,HGNC:HGNC:25635,MIM:616190 cap methyltransferase 2 GO:0004483,GO:0005634,GO:0005737,GO:0006370,GO:0097310 mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleus|cytoplasm|7-methylguanosine mRNA capping|cap2 mRNA methylation CMYA5 2.99278204584242 2.59443583384164 3.3911282578432 1.30707732818425 0.386344495140871 0.921829859631654 1 0.0067224 0.00429009 0.00430222 0.00801422 GeneID:202333,Genbank:XM_017009212.1,HGNC:HGNC:14305,MIM:612193 cardiomyopathy associated 5 GO:0031430,GO:0048471 M band|perinuclear region of cytoplasm CNBD1 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0386468 0 GeneID:168975,Genbank:XM_017013149.1,HGNC:HGNC:26663 cyclic nucleotide binding domain containing 1 CNBD2 14.4556128957144 16.7966978354972 12.1145279559317 0.72124462049496 -0.471439441634181 0.543852099983411 1 0.0252658 0.0549473 0.0241367 0.0149669 GeneID:140894,Genbank:XM_011528593.2,HGNC:HGNC:16145 cyclic nucleotide binding domain containing 2 GO:0005829,GO:0007283,GO:0030552 cytosol|spermatogenesis|cAMP binding CNBP 5737.80796526306 6481.76321893849 4993.85271158764 0.770446642820358 -0.37623304834063 0.00462969556600846 0.268656536902868 80.1072 76.0235 58.1368 61.9614 GeneID:7555,Genbank:NM_001127196.1,HGNC:HGNC:13164,MIM:116955 CCHC-type zinc finger nucleic acid binding protein GO:0000122,GO:0000977,GO:0001227,GO:0003697,GO:0003727,GO:0005634,GO:0005783,GO:0005829,GO:0006351,GO:0008270,GO:0008284,GO:0045893,GO:0045944 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|single-stranded DNA binding|single-stranded RNA binding|nucleus|endoplasmic reticulum|cytosol|transcription, DNA-templated|zinc ion binding|positive regulation of cell proliferation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter CNDP2 1188.46994631551 1213.8364623549 1163.10343027612 0.958204392723254 -0.0615946676145886 0.679256991216961 1 5.93566 5.85206 5.79369 5.54754 GeneID:55748,Genbank:NM_018235.2,HGNC:HGNC:24437,MIM:169800 carnosine dipeptidase 2 GO:0004180,GO:0005654,GO:0005829,GO:0006750,GO:0008237,GO:0046872,GO:0070062,GO:0102008,GO:0103046 carboxypeptidase activity|nucleoplasm|cytosol|glutathione biosynthetic process|metallopeptidase activity|metal ion binding|extracellular exosome|cytosolic dipeptidase activity|alanylglutamate dipeptidase activity hsa00330,hsa00340,hsa00410 Arginine and proline metabolism|Histidine metabolism|beta-Alanine metabolism CNEP1R1 396.539676364862 405.838628398759 387.240724330965 0.95417414024591 -0.0676755075428555 0.728330848095053 1 10.1959 10.2329 10.6691 9.15103 GeneID:255919,Genbank:NM_153261.5,HGNC:HGNC:26759,MIM:616869 CTD nuclear envelope phosphatase 1 regulatory subunit 1 GO:0005635,GO:0005737,GO:0005829,GO:0006629,GO:0007077,GO:0010867,GO:0016021,GO:0031965,GO:0034504,GO:0035307,GO:0071595 nuclear envelope|cytoplasm|cytosol|lipid metabolic process|mitotic nuclear envelope disassembly|positive regulation of triglyceride biosynthetic process|integral component of membrane|nuclear membrane|protein localization to nucleus|positive regulation of protein dephosphorylation|Nem1-Spo7 phosphatase complex CNFN 14.5874118190792 14.1542357269706 15.0205879111877 1.06120798048928 0.0857074300658073 0.982834084122048 1 1.03446 1.56318 0.94364 1.76168 GeneID:84518,Genbank:XM_005259332.3,HGNC:HGNC:30183,MIM:611764 cornifelin GO:0001533,GO:0005737,GO:0031424,GO:0070062 cornified envelope|cytoplasm|keratinization|extracellular exosome CNGA3 2.43404275359614 1.96028560782945 2.90779989936283 1.48335522525339 0.568864127356602 0.909379550164811 1 0 0.0310715 0.0161104 0.0224581 GeneID:1261,Genbank:NM_001298.2,HGNC:HGNC:2150,MIM:600053 cyclic nucleotide gated channel alpha 3 hsa04024,hsa04740 cAMP signaling pathway|Olfactory transduction CNGA4 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00857216 GeneID:1262,Genbank:XM_024448352.1,HGNC:HGNC:2152,MIM:609472 cyclic nucleotide gated channel alpha 4 GO:0000139,GO:0005249,GO:0005887,GO:0007608,GO:0030552,GO:0030660,GO:0042391,GO:0050896,GO:0060170 Golgi membrane|voltage-gated potassium channel activity|integral component of plasma membrane|sensory perception of smell|cAMP binding|Golgi-associated vesicle membrane|regulation of membrane potential|response to stimulus|ciliary membrane hsa04024,hsa04740 cAMP signaling pathway|Olfactory transduction CNGB1 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00524295 0 0 0 GeneID:1258,Genbank:NM_001286130.1,HGNC:HGNC:2151,MIM:600724 cyclic nucleotide gated channel beta 1 GO:0000139,GO:0001750,GO:0001895,GO:0005222,GO:0005223,GO:0005249,GO:0005886,GO:0005887,GO:0006810,GO:0006812,GO:0007601,GO:0007608,GO:0015276,GO:0016056,GO:0017071,GO:0022400,GO:0030552,GO:0030553,GO:0030660,GO:0033365,GO:0035845,GO:0042391,GO:0043195,GO:0045494,GO:0050908,GO:0051290,GO:0051480,GO:0060170,GO:1902495 Golgi membrane|photoreceptor outer segment|retina homeostasis|intracellular cAMP activated cation channel activity|intracellular cGMP activated cation channel activity|voltage-gated potassium channel activity|plasma membrane|integral component of plasma membrane|transport|cation transport|visual perception|sensory perception of smell|ligand-gated ion channel activity|rhodopsin mediated signaling pathway|intracellular cyclic nucleotide activated cation channel complex|regulation of rhodopsin mediated signaling pathway|cAMP binding|cGMP binding|Golgi-associated vesicle membrane|protein localization to organelle|photoreceptor cell outer segment organization|regulation of membrane potential|terminal bouton|photoreceptor cell maintenance|detection of light stimulus involved in visual perception|protein heterotetramerization|regulation of cytosolic calcium ion concentration|ciliary membrane|transmembrane transporter complex hsa04022,hsa04024,hsa04740,hsa04744 cGMP-PKG signaling pathway|cAMP signaling pathway|Olfactory transduction|Phototransduction CNGB3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:54714,Genbank:XM_011517138.2,HGNC:HGNC:2153,MIM:605080 cyclic nucleotide gated channel beta 3 GO:0001750,GO:0005223,GO:0005249,GO:0005887,GO:0006810,GO:0006812,GO:0007165,GO:0007601,GO:0030553,GO:0042391,GO:1902495 photoreceptor outer segment|intracellular cGMP activated cation channel activity|voltage-gated potassium channel activity|integral component of plasma membrane|transport|cation transport|signal transduction|visual perception|cGMP binding|regulation of membrane potential|transmembrane transporter complex hsa04024 cAMP signaling pathway CNIH1 1630.15528633159 1714.85276993615 1545.45780272702 0.901218944168928 -0.150050454670312 0.297399256316592 1 60.6617 62.4282 55.1615 54.0845 GeneID:10175,Genbank:NM_005776.2,HGNC:HGNC:19431,MIM:611287 cornichon family AMPA receptor auxiliary protein 1 GO:0000139,GO:0005789,GO:0006888,GO:0006955,GO:0007165,GO:0012507,GO:0016021,GO:0033116,GO:0048208 Golgi membrane|endoplasmic reticulum membrane|ER to Golgi vesicle-mediated transport|immune response|signal transduction|ER to Golgi transport vesicle membrane|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating CNIH2 93.489977878255 81.8114811607009 105.168474595809 1.28549774559427 0.362327080087697 0.234123952509616 1 3.7459 2.94934 4.23617 3.65036 GeneID:254263,Genbank:NM_182553.2,HGNC:HGNC:28744,MIM:611288 cornichon family AMPA receptor auxiliary protein 2 GO:0005789,GO:0014069,GO:0016192,GO:0016247,GO:0030054,GO:0030425,GO:0032281,GO:0035249,GO:0042391,GO:0043197,GO:0043198,GO:0045211,GO:0051668,GO:1902684,GO:1903743,GO:2000310,GO:2000311 endoplasmic reticulum membrane|postsynaptic density|vesicle-mediated transport|channel regulator activity|cell junction|dendrite|AMPA glutamate receptor complex|synaptic transmission, glutamatergic|regulation of membrane potential|dendritic spine|dendritic shaft|postsynaptic membrane|localization within membrane|negative regulation of receptor localization to synapse|negative regulation of anterograde synaptic vesicle transport|regulation of NMDA receptor activity|regulation of AMPA receptor activity CNIH3 324.493232397048 304.943788527044 344.042676267051 1.12821670488474 0.174044203406198 0.464550776190291 1 4.23149 4.42958 4.45128 5.60873 GeneID:149111,Genbank:NM_001322302.1,HGNC:HGNC:26802 cornichon family AMPA receptor auxiliary protein 3 GO:0000139,GO:0005789,GO:0006888,GO:0012507,GO:0016247,GO:0030054,GO:0032281,GO:0033116,GO:0035249,GO:0042391,GO:0043198,GO:0045211,GO:0048208,GO:2000311 Golgi membrane|endoplasmic reticulum membrane|ER to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|channel regulator activity|cell junction|AMPA glutamate receptor complex|endoplasmic reticulum-Golgi intermediate compartment membrane|synaptic transmission, glutamatergic|regulation of membrane potential|dendritic shaft|postsynaptic membrane|COPII vesicle coating|regulation of AMPA receptor activity CNIH4 1215.78660786418 1211.82815047238 1219.74506525598 1.00653303422644 0.00939452201840511 0.954140285031713 1 12.0373 12.2789 12.78 13.4099 GeneID:29097,Genbank:NM_001277200.1,HGNC:HGNC:25013,MIM:617483 cornichon family AMPA receptor auxiliary protein 4 GO:0005783,GO:0005793,GO:0006888,GO:0015031,GO:0016021,GO:0031730 endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|ER to Golgi vesicle-mediated transport|protein transport|integral component of membrane|CCR5 chemokine receptor binding CNKSR1 4.24784675950189 6.07296192222811 2.42273159677566 0.398937392956151 -1.32576573931368 0.397921406733426 1 0.0638751 0.110474 0.0294511 0.0275968 GeneID:10256,Genbank:NM_001297647.1,HGNC:HGNC:19700,MIM:603272 connector enhancer of kinase suppressor of Ras 1 GO:0005886,GO:0005911,GO:0005938,GO:0007169,GO:0007265,GO:0007266,GO:0030674 plasma membrane|cell-cell junction|cell cortex|transmembrane receptor protein tyrosine kinase signaling pathway|Ras protein signal transduction|Rho protein signal transduction|protein binding, bridging CNKSR2 95.3169317569043 88.8547772317358 101.779086282073 1.14545429579582 0.195919895531145 0.506407721624206 1 0.328973 0.266253 0.387382 0.322875 GeneID:22866,Genbank:NM_014927.4,HGNC:HGNC:19701,MIM:300724 connector enhancer of kinase suppressor of Ras 2 GO:0005737,GO:0009966,GO:0014069,GO:0042802,GO:0043005,GO:0043025,GO:0045211,GO:0070062 cytoplasm|regulation of signal transduction|postsynaptic density|identical protein binding|neuron projection|neuronal cell body|postsynaptic membrane|extracellular exosome CNKSR3 449.9281341316 434.589144979972 465.267123283227 1.07059076062443 0.0984071071221294 0.585068136144816 1 2.46592 2.48837 3.0147 2.45015 GeneID:154043,Genbank:XM_011535485.3,HGNC:HGNC:23034,MIM:617476 CNKSR family member 3 GO:0005737,GO:0010765,GO:0016324,GO:0033137,GO:0070373 cytoplasm|positive regulation of sodium ion transport|apical plasma membrane|negative regulation of peptidyl-serine phosphorylation|negative regulation of ERK1 and ERK2 cascade CNN1 11.345365484661 15.422536178995 7.26819479032697 0.471271048157827 -1.08537104065504 0.215321089556695 1 0.129728 0.12548 0.0723708 0.0901606 GeneID:1264,Genbank:NM_001308341.1,HGNC:HGNC:2155,MIM:600806 calponin 1 GO:0003779,GO:0005516,GO:0005856,GO:0005925,GO:0006940,GO:0031032,GO:1904706 actin binding|calmodulin binding|cytoskeleton|focal adhesion|regulation of smooth muscle contraction|actomyosin structure organization|negative regulation of vascular smooth muscle cell proliferation CNN2 5545.73418162657 5849.96585197296 5241.50251128017 0.895988565388363 -0.158447774170071 0.221272810312976 1 90.6543 96.3157 82.6649 88.8651 GeneID:1265,Genbank:NM_001303501.1,HGNC:HGNC:2156,MIM:602373 calponin 2 GO:0001725,GO:0003779,GO:0005516,GO:0005576,GO:0005856,GO:0005911,GO:0005925,GO:0007010,GO:0016020,GO:0031032,GO:0032970,GO:0035580,GO:0035722,GO:0043312,GO:0045296,GO:0070062,GO:0071260,GO:1904724 stress fiber|actin binding|calmodulin binding|extracellular region|cytoskeleton|cell-cell junction|focal adhesion|cytoskeleton organization|membrane|actomyosin structure organization|regulation of actin filament-based process|specific granule lumen|interleukin-12-mediated signaling pathway|neutrophil degranulation|cadherin binding|extracellular exosome|cellular response to mechanical stimulus|tertiary granule lumen CNN3 12682.7211180463 12811.3263156306 12554.115920462 0.979923203200682 -0.0292594055604425 0.818613011290641 1 89.8028 94.1487 89.8645 90.3486 GeneID:1266,Genbank:NM_001286055.1,HGNC:HGNC:2157,MIM:602374 calponin 3 GO:0003779,GO:0005516,GO:0005829,GO:0005913,GO:0005925,GO:0008017,GO:0014069,GO:0015629,GO:0030855,GO:0031032,GO:0032780,GO:0043025,GO:0043197,GO:0098641 actin binding|calmodulin binding|cytosol|cell-cell adherens junction|focal adhesion|microtubule binding|postsynaptic density|actin cytoskeleton|epithelial cell differentiation|actomyosin structure organization|negative regulation of ATPase activity|neuronal cell body|dendritic spine|cadherin binding involved in cell-cell adhesion CNNM1 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.012579 0 0 GeneID:26507,Genbank:NM_001345887.1,HGNC:HGNC:102,MIM:607802 cyclin and CBS domain divalent metal cation transport mediator 1 GO:0005886,GO:0006811,GO:0016021,GO:0030425,GO:0043025 plasma membrane|ion transport|integral component of membrane|dendrite|neuronal cell body CNNM2 455.960438459488 380.74014269531 531.180734223665 1.39512668788577 0.480396135449279 0.00730014108683525 0.339880987345213 2.25809 2.36576 3.61497 3.12752 GeneID:54805,Genbank:XM_005269933.4,HGNC:HGNC:103,MIM:607803 cyclin and CBS domain divalent metal cation transport mediator 2 GO:0005524,GO:0010960,GO:0015095,GO:0016021,GO:0016323,GO:0043231 ATP binding|magnesium ion homeostasis|magnesium ion transmembrane transporter activity|integral component of membrane|basolateral plasma membrane|intracellular membrane-bounded organelle CNNM3 848.870640135768 900.524259375855 797.217020895682 0.885281004476466 -0.175792629051559 0.250308557744806 1 6.04876 6.73937 6.05133 5.66515 GeneID:26505,Genbank:XM_011510957.3,HGNC:HGNC:104,MIM:607804 cyclin and CBS domain divalent metal cation transport mediator 3 GO:0005886,GO:0006811,GO:0016020,GO:0016021 plasma membrane|ion transport|membrane|integral component of membrane CNNM4 472.267442240872 457.958684794763 486.57619968698 1.06248929399612 0.0874483042371452 0.633253884329592 1 3.08515 3.16094 3.51321 3.16998 GeneID:26504,Genbank:NM_020184.3,HGNC:HGNC:105,MIM:607805 cyclin and CBS domain divalent metal cation transport mediator 4 GO:0007601,GO:0010960,GO:0015081,GO:0015095,GO:0016021,GO:0016323,GO:0030425,GO:0043025,GO:0043234,GO:0050896,GO:0055065,GO:0070166 visual perception|magnesium ion homeostasis|sodium ion transmembrane transporter activity|magnesium ion transmembrane transporter activity|integral component of membrane|basolateral plasma membrane|dendrite|neuronal cell body|protein complex|response to stimulus|metal ion homeostasis|enamel mineralization CNOT1 4216.9346672737 4491.94420888639 3941.92512566101 0.877554337799369 -0.188439635627879 0.320353711696752 1 17.8462 15.822 17.1903 12.6958 GeneID:23019,Genbank:NM_001265612.1,HGNC:HGNC:7877,MIM:604917 CCR4-NOT transcription complex subunit 1 GO:0000122,GO:0000289,GO:0000932,GO:0003723,GO:0005615,GO:0005634,GO:0005778,GO:0005829,GO:0006351,GO:0006977,GO:0007275,GO:0010606,GO:0016020,GO:0017148,GO:0019904,GO:0030014,GO:0030015,GO:0030331,GO:0032947,GO:0033147,GO:0035195,GO:0042974,GO:0048387,GO:0060213,GO:0061014,GO:0070016,GO:0090503,GO:1900153,GO:2000036 negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA poly(A) tail shortening|P-body|RNA binding|extracellular space|nucleus|peroxisomal membrane|cytosol|transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|multicellular organism development|positive regulation of cytoplasmic mRNA processing body assembly|membrane|negative regulation of translation|protein domain specific binding|CCR4-NOT complex|CCR4-NOT core complex|estrogen receptor binding|protein complex scaffold activity|negative regulation of intracellular estrogen receptor signaling pathway|gene silencing by miRNA|retinoic acid receptor binding|negative regulation of retinoic acid receptor signaling pathway|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of mRNA catabolic process|armadillo repeat domain binding|RNA phosphodiester bond hydrolysis, exonucleolytic|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|regulation of stem cell population maintenance hsa03018 RNA degradation CNOT10 595.035963362014 619.66938778302 570.402538941007 0.920494944863625 -0.119518296223865 0.478671668521974 1 5.79098 6.45077 6.07558 5.89565 GeneID:25904,Genbank:NM_015442.2,HGNC:HGNC:23817 CCR4-NOT transcription complex subunit 10 GO:0000289,GO:0005634,GO:0005829,GO:0006351,GO:0006355,GO:0006417,GO:0006977,GO:0016020,GO:0030014,GO:0031047 nuclear-transcribed mRNA poly(A) tail shortening|nucleus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of translation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|membrane|CCR4-NOT complex|gene silencing by RNA hsa03018 RNA degradation CNOT11 1049.57316975487 1131.80345013013 967.342889379609 0.854691589134479 -0.226524169735847 0.136724315323593 1 22.9802 22.4974 20.6446 18.6695 GeneID:55571,Genbank:NM_017546.4,HGNC:HGNC:25217 CCR4-NOT transcription complex subunit 11 GO:0000289,GO:0005634,GO:0005829,GO:0006351,GO:0006355,GO:0006417,GO:0006977,GO:0008283,GO:0030014,GO:0031047 nuclear-transcribed mRNA poly(A) tail shortening|nucleus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of translation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell proliferation|CCR4-NOT complex|gene silencing by RNA CNOT2 677.090910846187 690.737515720236 663.444305972137 0.960486857703624 -0.0581622211897128 0.738728252026328 1 4.50057 4.11963 4.20003 4.14947 GeneID:4848,Genbank:XM_024448986.1,HGNC:HGNC:7878,MIM:604909 CCR4-NOT transcription complex subunit 2 GO:0000122,GO:0000288,GO:0000289,GO:0000932,GO:0001104,GO:0001226,GO:0001829,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0006357,GO:0006977,GO:0010606,GO:0016020,GO:0017148,GO:0030014,GO:0030015,GO:0031047,GO:0033147,GO:0090503,GO:2000036 negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|P-body|RNA polymerase II transcription cofactor activity|RNA polymerase II transcription corepressor binding|trophectodermal cell differentiation|nucleus|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cytoplasmic mRNA processing body assembly|membrane|negative regulation of translation|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by RNA|negative regulation of intracellular estrogen receptor signaling pathway|RNA phosphodiester bond hydrolysis, exonucleolytic|regulation of stem cell population maintenance hsa03018 RNA degradation CNOT3 1617.66638266121 1620.07993526221 1615.25283006021 0.99702045244995 -0.00430499513302728 0.963688893931763 1 11.6767 11.5515 11.5595 11.1702 GeneID:4849,Genbank:XM_005278280.2,HGNC:HGNC:7879,MIM:604910 CCR4-NOT transcription complex subunit 3 GO:0000288,GO:0000289,GO:0000932,GO:0001829,GO:0005634,GO:0005829,GO:0006351,GO:0006355,GO:0006977,GO:0017148,GO:0030014,GO:0030015,GO:0031047,GO:2000036 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|P-body|trophectodermal cell differentiation|nucleus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of translation|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by RNA|regulation of stem cell population maintenance hsa03018 RNA degradation CNOT4 430.644903652879 436.279873249053 425.009934056706 0.974168097399456 -0.037757357117774 0.860083572398904 1 2.80958 2.57787 2.75064 2.77558 GeneID:4850,Genbank:NM_013316.3,HGNC:HGNC:7880,MIM:604911 CCR4-NOT transcription complex subunit 4 GO:0000288,GO:0000289,GO:0003723,GO:0004842,GO:0005634,GO:0005829,GO:0006977,GO:0046872,GO:0051865 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|ubiquitin-protein transferase activity|nucleus|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|metal ion binding|protein autoubiquitination hsa03018 RNA degradation CNOT6 1011.24224969061 1097.71017440207 924.774324979147 0.842457641866056 -0.247323944386381 0.12086318012136 1 6.12287 6.50144 6.17528 4.6082 GeneID:57472,Genbank:XM_024446137.1,HGNC:HGNC:14099,MIM:608951 CCR4-NOT transcription complex subunit 6 GO:0000289,GO:0003723,GO:0004532,GO:0004535,GO:0005634,GO:0005829,GO:0006351,GO:0006355,GO:0006977,GO:0008284,GO:0010606,GO:0016020,GO:0030014,GO:0035195,GO:0043928,GO:0046872,GO:0070966,GO:2000327 nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|exoribonuclease activity|poly(A)-specific ribonuclease activity|nucleus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cell proliferation|positive regulation of cytoplasmic mRNA processing body assembly|membrane|CCR4-NOT complex|gene silencing by miRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|metal ion binding|nuclear-transcribed mRNA catabolic process, no-go decay|positive regulation of ligand-dependent nuclear receptor transcription coactivator activity hsa03018 RNA degradation CNOT6L 217.029842955208 222.71867120354 211.341014706875 0.948914671431983 -0.0756497322317189 0.828796232253645 1 1.09015 1.02999 1.25787 0.753039 GeneID:246175,Genbank:XM_011531810.2,HGNC:HGNC:18042 CCR4-NOT transcription complex subunit 6 like GO:0000289,GO:0004535,GO:0005634,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0006397,GO:0006977,GO:0008284,GO:0010606,GO:0030014,GO:0031047,GO:0046872,GO:0061157 nuclear-transcribed mRNA poly(A) tail shortening|poly(A)-specific ribonuclease activity|nucleus|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA processing|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cell proliferation|positive regulation of cytoplasmic mRNA processing body assembly|CCR4-NOT complex|gene silencing by RNA|metal ion binding|mRNA destabilization hsa03018 RNA degradation CNOT7 2096.00593814499 2211.73576689194 1980.27610939804 0.895349317509496 -0.159477440089263 0.264845652746183 1 5.7497 5.43712 5.13733 4.52267 GeneID:29883,Genbank:XM_005273481.3,HGNC:HGNC:14101,MIM:604913 CCR4-NOT transcription complex subunit 7 GO:0000122,GO:0000175,GO:0000289,GO:0000290,GO:0000932,GO:0001191,GO:0003723,GO:0004532,GO:0004535,GO:0005634,GO:0005737,GO:0006351,GO:0008134,GO:0008284,GO:0008285,GO:0010629,GO:0016604,GO:0016607,GO:0017148,GO:0030014,GO:0030015,GO:0031047,GO:0033962,GO:0042509,GO:0043928,GO:0045070,GO:0045892,GO:0045944,GO:0046872,GO:0051607,GO:0060213,GO:0060339,GO:0061014,GO:0075341,GO:1900153 negative regulation of transcription from RNA polymerase II promoter|3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA binding|exoribonuclease activity|poly(A)-specific ribonuclease activity|nucleus|cytoplasm|transcription, DNA-templated|transcription factor binding|positive regulation of cell proliferation|negative regulation of cell proliferation|negative regulation of gene expression|nuclear body|nuclear speck|negative regulation of translation|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by RNA|cytoplasmic mRNA processing body assembly|regulation of tyrosine phosphorylation of STAT protein|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|positive regulation of viral genome replication|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|defense response to virus|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|negative regulation of type I interferon-mediated signaling pathway|positive regulation of mRNA catabolic process|host cell PML body|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay hsa03018 RNA degradation CNOT8 1134.20151789171 1152.7510418996 1115.65199388381 0.96781694687982 -0.0471938932574653 0.762678257333113 1 11.3151 11.7535 11.6779 10.279 GeneID:9337,Genbank:XM_017010051.1,HGNC:HGNC:9207,MIM:603731 CCR4-NOT transcription complex subunit 8 GO:0000175,GO:0000289,GO:0000932,GO:0003700,GO:0003723,GO:0004535,GO:0005622,GO:0005634,GO:0005829,GO:0006351,GO:0006355,GO:0006977,GO:0008284,GO:0008285,GO:0030014,GO:0030015,GO:0035195,GO:0043928,GO:0046872,GO:0061014 3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|P-body|DNA binding transcription factor activity|RNA binding|poly(A)-specific ribonuclease activity|intracellular|nucleus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|positive regulation of cell proliferation|negative regulation of cell proliferation|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by miRNA|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|metal ion binding|positive regulation of mRNA catabolic process hsa03018 RNA degradation CNOT9 1540.8232870285 1765.9937005291 1315.65287352791 0.744992959563637 -0.424701303206014 0.00356327331738006 0.22919431908096 10.7955 12.4743 7.88275 9.3156 GeneID:9125,Genbank:XM_017005249.2,HGNC:HGNC:10445,MIM:612054 CCR4-NOT transcription complex subunit 9 GO:0000288,GO:0000289,GO:0000932,GO:0005154,GO:0005634,GO:0005829,GO:0006351,GO:0006355,GO:0006977,GO:0007548,GO:0016020,GO:0017148,GO:0019221,GO:0019900,GO:0019904,GO:0030014,GO:0030015,GO:0031047,GO:0033138,GO:0033147,GO:0042803,GO:0043234,GO:0045742,GO:2000327 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|nuclear-transcribed mRNA poly(A) tail shortening|P-body|epidermal growth factor receptor binding|nucleus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|sex differentiation|membrane|negative regulation of translation|cytokine-mediated signaling pathway|kinase binding|protein domain specific binding|CCR4-NOT complex|CCR4-NOT core complex|gene silencing by RNA|positive regulation of peptidyl-serine phosphorylation|negative regulation of intracellular estrogen receptor signaling pathway|protein homodimerization activity|protein complex|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of ligand-dependent nuclear receptor transcription coactivator activity hsa03018 RNA degradation CNP 5953.59252882712 5374.50765853093 6532.67739912331 1.21549317894338 0.281541797330303 0.0346916599359953 0.730000079237491 33.9416 36.5644 47.8285 40.2868 GeneID:1267,Genbank:NM_033133.4,HGNC:HGNC:2158,MIM:123830 2',3'-cyclic nucleotide 3' phosphodiesterase GO:0000226,GO:0003723,GO:0004113,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005741,GO:0005743,GO:0005829,GO:0005874,GO:0005886,GO:0005902,GO:0007268,GO:0007409,GO:0007568,GO:0008344,GO:0009214,GO:0009636,GO:0016020,GO:0021762,GO:0030551,GO:0030900,GO:0031143,GO:0032496,GO:0035748,GO:0035749,GO:0042470,GO:0046902,GO:0048471,GO:0048709,GO:0070062 microtubule cytoskeleton organization|RNA binding|2',3'-cyclic-nucleotide 3'-phosphodiesterase activity|extracellular space|nucleus|nucleoplasm|cytoplasm|mitochondrial outer membrane|mitochondrial inner membrane|cytosol|microtubule|plasma membrane|microvillus|chemical synaptic transmission|axonogenesis|aging|adult locomotory behavior|cyclic nucleotide catabolic process|response to toxic substance|membrane|substantia nigra development|cyclic nucleotide binding|forebrain development|pseudopodium|response to lipopolysaccharide|myelin sheath abaxonal region|myelin sheath adaxonal region|melanosome|regulation of mitochondrial membrane permeability|perinuclear region of cytoplasm|oligodendrocyte differentiation|extracellular exosome CNPPD1 1268.63959553963 1234.62137499095 1302.6578160883 1.05510713039279 0.0773894905340597 0.610931692496922 1 22.7567 22.9263 23.9434 24.3068 GeneID:27013,Genbank:XM_024452790.1,HGNC:HGNC:25220 cyclin Pas1/PHO80 domain containing 1 GO:0000079,GO:0016021,GO:0019901 regulation of cyclin-dependent protein serine/threonine kinase activity|integral component of membrane|protein kinase binding CNPY1 2.0008072334591 2.54640955915669 1.45520490776151 0.571473234746824 -0.8072421642556 0.825091795897871 1 0 0.0417898 0.0415612 0 GeneID:285888,Genbank:NM_001103176.1,HGNC:HGNC:27786,MIM:612493 canopy FGF signaling regulator 1 GO:0005783,GO:0007167,GO:0009888 endoplasmic reticulum|enzyme linked receptor protein signaling pathway|tissue development CNPY2 1647.30191187187 1603.85955272293 1690.74427102081 1.05417227347019 0.0761106523374518 0.60630616187823 1 20.2218 21.8751 20.9395 23.7374 GeneID:10330,Genbank:NM_014255.6,HGNC:HGNC:13529,MIM:605861 canopy FGF signaling regulator 2 GO:0005783,GO:0005887,GO:0007167,GO:0009888,GO:0010629,GO:0010988,GO:0045716 endoplasmic reticulum|integral component of plasma membrane|enzyme linked receptor protein signaling pathway|tissue development|negative regulation of gene expression|regulation of low-density lipoprotein particle clearance|positive regulation of low-density lipoprotein particle receptor biosynthetic process CNPY3 1641.29249753545 1639.27998083366 1643.30501423725 1.00245536665527 0.00353800352450016 0.993440757327405 1 22.5188 24.8001 23.2597 24.7118 GeneID:10695,Genbank:NM_001318842.1,HGNC:HGNC:11968,MIM:610774 canopy FGF signaling regulator 3 GO:0002224,GO:0005102,GO:0005788,GO:0045087 toll-like receptor signaling pathway|receptor binding|endoplasmic reticulum lumen|innate immune response CNPY4 326.334830506955 302.29151776341 350.3781432505 1.15907368437882 0.212972283953417 0.274759005635525 1 6.07012 5.59036 6.95371 6.9401 GeneID:245812,Genbank:NM_152755.1,HGNC:HGNC:28631,MIM:610047 canopy FGF signaling regulator 4 GO:0005102,GO:0005576,GO:1903078 receptor binding|extracellular region|positive regulation of protein localization to plasma membrane CNR1 2533.32109588879 2397.50596084908 2669.13623092851 1.11329701552993 0.154838539370863 0.433182272205054 1 7.91176 6.91579 9.56829 7.0763 GeneID:1268,Genbank:XM_017010240.2,HGNC:HGNC:2159,MIM:114610 cannabinoid receptor 1 GO:0002866,GO:0004949,GO:0005741,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007188,GO:0007283,GO:0007413,GO:0007568,GO:0007584,GO:0007613,GO:0008144,GO:0010976,GO:0019233,GO:0030424,GO:0030426,GO:0031622,GO:0031999,GO:0032228,GO:0032496,GO:0033004,GO:0033602,GO:0035094,GO:0038171,GO:0042220,GO:0042593,GO:0042734,GO:0043065,GO:0043278,GO:0045121,GO:0045471,GO:0045759,GO:0045776,GO:0045777,GO:0050796,GO:0051001,GO:0051966,GO:0060135,GO:0060259,GO:0060405,GO:0099553 positive regulation of acute inflammatory response to antigenic stimulus|cannabinoid receptor activity|mitochondrial outer membrane|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|spermatogenesis|axonal fasciculation|aging|response to nutrient|memory|drug binding|positive regulation of neuron projection development|sensory perception of pain|axon|growth cone|positive regulation of fever generation|negative regulation of fatty acid beta-oxidation|regulation of synaptic transmission, GABAergic|response to lipopolysaccharide|negative regulation of mast cell activation|negative regulation of dopamine secretion|response to nicotine|cannabinoid signaling pathway|response to cocaine|glucose homeostasis|presynaptic membrane|positive regulation of apoptotic process|response to morphine|membrane raft|response to ethanol|negative regulation of action potential|negative regulation of blood pressure|positive regulation of blood pressure|regulation of insulin secretion|negative regulation of nitric-oxide synthase activity|regulation of synaptic transmission, glutamatergic|maternal process involved in female pregnancy|regulation of feeding behavior|regulation of penile erection|trans-synaptic signaling by endocannabinoid, modulating synaptic transmission hsa04015,hsa04080,hsa04714,hsa04723 Rap1 signaling pathway|Neuroactive ligand-receptor interaction|Thermogenesis|Retrograde endocannabinoid signaling CNR2 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0224598 0 0 0 GeneID:1269,Genbank:XM_011540629.3,HGNC:HGNC:2160,MIM:605051 cannabinoid receptor 2 GO:0001975,GO:0004949,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007186,GO:0007187,GO:0019233,GO:0030425,GO:0030595,GO:0031234,GO:0032229,GO:0032496,GO:0033004,GO:0043204,GO:0045759,GO:0050728,GO:0051001 response to amphetamine|cannabinoid receptor activity|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|sensory perception of pain|dendrite|leukocyte chemotaxis|extrinsic component of cytoplasmic side of plasma membrane|negative regulation of synaptic transmission, GABAergic|response to lipopolysaccharide|negative regulation of mast cell activation|perikaryon|negative regulation of action potential|negative regulation of inflammatory response|negative regulation of nitric-oxide synthase activity hsa04080 Neuroactive ligand-receptor interaction CNRIP1 1174.7875443174 1271.76973198949 1077.80535664531 0.847484673942706 -0.238740816345498 0.108031688816276 1 24.8235 25.8778 22.4524 21.6477 GeneID:25927,Genbank:NM_001111101.1,HGNC:HGNC:24546 cannabinoid receptor interacting protein 1 GO:0005737,GO:0005886,GO:0008022,GO:0010469,GO:0031718,GO:0043209,GO:2000272 cytoplasm|plasma membrane|protein C-terminus binding|regulation of receptor activity|type 1 cannabinoid receptor binding|myelin sheath|negative regulation of receptor activity CNST 410.120001990095 409.730790649948 410.509213330241 1.0018998393532 0.00273828848207921 1 1 2.06688 2.33463 2.42299 1.94029 GeneID:163882,Genbank:NM_152609.2,HGNC:HGNC:26486,MIM:613439 consortin, connexin sorting protein GO:0005802,GO:0005886,GO:0010923,GO:0016020,GO:0016021,GO:0019902,GO:0030133,GO:0042998,GO:0043231,GO:0043234,GO:0071253 trans-Golgi network|plasma membrane|negative regulation of phosphatase activity|membrane|integral component of membrane|phosphatase binding|transport vesicle|positive regulation of Golgi to plasma membrane protein transport|intracellular membrane-bounded organelle|protein complex|connexin binding CNTD1 58.285168074863 56.4914643931888 60.0788717565373 1.06350352928329 0.088824820953541 0.863194806045172 1 0.440137 0.27765 0.397401 0.554929 GeneID:124817,Genbank:XM_011524311.2,HGNC:HGNC:26847 cyclin N-terminal domain containing 1 GO:0007131,GO:0007283 reciprocal meiotic recombination|spermatogenesis CNTD2 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0273762 0 0.0273116 GeneID:79935,Genbank:XM_006723395.3,HGNC:HGNC:25805 cyclin N-terminal domain containing 2 CNTF 25.1095107646825 20.6594341213632 29.5595874080019 1.4308033431291 0.51682539436424 0.362832925235509 1 0.573433 0.436821 0.52283 0.803488 GeneID:1270,Genbank:NM_000614.3,HGNC:HGNC:2169,MIM:118945 ciliary neurotrophic factor hsa04060,hsa04630 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway CNTFR 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:1271,Genbank:XM_017014263.1,HGNC:HGNC:2170,MIM:118946 ciliary neurotrophic factor receptor GO:0001967,GO:0003360,GO:0004897,GO:0005102,GO:0005886,GO:0007165,GO:0007399,GO:0007548,GO:0008284,GO:0016324,GO:0019221,GO:0019898,GO:0019955,GO:0031225,GO:0043524,GO:0060538,GO:0070110,GO:0070120,GO:0097059 suckling behavior|brainstem development|ciliary neurotrophic factor receptor activity|receptor binding|plasma membrane|signal transduction|nervous system development|sex differentiation|positive regulation of cell proliferation|apical plasma membrane|cytokine-mediated signaling pathway|extrinsic component of membrane|cytokine binding|anchored component of membrane|negative regulation of neuron apoptotic process|skeletal muscle organ development|ciliary neurotrophic factor receptor complex|ciliary neurotrophic factor-mediated signaling pathway|CNTFR-CLCF1 complex hsa04060,hsa04630 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway CNTLN 161.605893098833 156.463996390781 166.747789806885 1.06572626069463 0.0918369192853526 0.806109068944924 1 0.355629 0.314167 0.465176 0.272995 GeneID:54875,Genbank:XM_017014840.2,HGNC:HGNC:23432,MIM:611870 centlein GO:0005654,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0010457,GO:0019901,GO:0019904,GO:0030674,GO:0033365,GO:0070062 nucleoplasm|cytoplasm|centrosome|centriole|cytosol|centriole-centriole cohesion|protein kinase binding|protein domain specific binding|protein binding, bridging|protein localization to organelle|extracellular exosome CNTN1 229.567978476867 240.033849405464 219.10210754827 0.912796708009977 -0.131634506313183 0.762077267788621 1 1.08515 0.887416 1.15542 0.649609 GeneID:1272,Genbank:XM_011537926.3,HGNC:HGNC:2171,MIM:600016 contactin 1 GO:0005886,GO:0007155,GO:0007219,GO:0010628,GO:0010765,GO:0010976,GO:0016020,GO:0021549,GO:0030246,GO:0031175,GO:0031225,GO:0043209,GO:0045121,GO:0050731,GO:0070062 plasma membrane|cell adhesion|Notch signaling pathway|positive regulation of gene expression|positive regulation of sodium ion transport|positive regulation of neuron projection development|membrane|cerebellum development|carbohydrate binding|neuron projection development|anchored component of membrane|myelin sheath|membrane raft|positive regulation of peptidyl-tyrosine phosphorylation|extracellular exosome hsa04514 Cell adhesion molecules (CAMs) CNTN5 1.6955641289216 0 3.3911282578432 Inf Inf 0.190761613265799 1 0 0 0.00479007 0.0222765 GeneID:53942,Genbank:XM_017017926.1,HGNC:HGNC:2175,MIM:607219 contactin 5 GO:0005576,GO:0005829,GO:0005886,GO:0006501,GO:0007155,GO:0007605,GO:0031225 extracellular region|cytosol|plasma membrane|C-terminal protein lipidation|cell adhesion|sensory perception of sound|anchored component of membrane CNTN6 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00568609 0 0 0 GeneID:27255,Genbank:XM_017006171.1,HGNC:HGNC:2176,MIM:607220 contactin 6 GO:0005112,GO:0005886,GO:0007155,GO:0007219,GO:0007417,GO:0030182,GO:0031225,GO:0045747 Notch binding|plasma membrane|cell adhesion|Notch signaling pathway|central nervous system development|neuron differentiation|anchored component of membrane|positive regulation of Notch signaling pathway CNTNAP1 1219.20174891942 1191.50591727467 1246.89758056417 1.04648878573444 0.0655568516299379 0.676658393270159 1 5.50049 5.83753 5.86388 6.17918 GeneID:8506,Genbank:XM_024451011.1,HGNC:HGNC:8011,MIM:602346 contactin associated protein 1 GO:0002175,GO:0004872,GO:0005070,GO:0005887,GO:0007010,GO:0007155,GO:0007165,GO:0008076,GO:0016021,GO:0017124,GO:0019227,GO:0022010,GO:0022011,GO:0030913,GO:0033010,GO:0033270,GO:0043209,GO:0048812,GO:0050884,GO:0050885,GO:0071205 protein localization to paranode region of axon|receptor activity|SH3/SH2 adaptor activity|integral component of plasma membrane|cytoskeleton organization|cell adhesion|signal transduction|voltage-gated potassium channel complex|integral component of membrane|SH3 domain binding|neuronal action potential propagation|central nervous system myelination|myelination in peripheral nervous system|paranodal junction assembly|paranodal junction|paranode region of axon|myelin sheath|neuron projection morphogenesis|neuromuscular process controlling posture|neuromuscular process controlling balance|protein localization to juxtaparanode region of axon hsa04514 Cell adhesion molecules (CAMs) CNTNAP2 14.4863690765339 17.8248669140969 11.1478712389709 0.625411190596582 -0.677123060987772 0.372898321974075 1 0.0513086 0.0776639 0.0452894 0.0315945 GeneID:26047,Genbank:XM_017011950.2,HGNC:HGNC:13830,MIM:604569 contactin associated protein like 2 GO:0005769,GO:0005794,GO:0007155,GO:0007420,GO:0007612,GO:0008038,GO:0008076,GO:0009986,GO:0016020,GO:0016021,GO:0019226,GO:0019899,GO:0021756,GO:0021761,GO:0021794,GO:0021987,GO:0030424,GO:0030425,GO:0030534,GO:0030673,GO:0031175,GO:0033010,GO:0035176,GO:0042297,GO:0043025,GO:0043204,GO:0044224,GO:0045163,GO:0048812,GO:0071109,GO:0071205,GO:0071625 early endosome|Golgi apparatus|cell adhesion|brain development|learning|neuron recognition|voltage-gated potassium channel complex|cell surface|membrane|integral component of membrane|transmission of nerve impulse|enzyme binding|striatum development|limbic system development|thalamus development|cerebral cortex development|axon|dendrite|adult behavior|axolemma|neuron projection development|paranodal junction|social behavior|vocal learning|neuronal cell body|perikaryon|juxtaparanode region of axon|clustering of voltage-gated potassium channels|neuron projection morphogenesis|superior temporal gyrus development|protein localization to juxtaparanode region of axon|vocalization behavior hsa04514 Cell adhesion molecules (CAMs) CNTNAP3 129.257496513165 131.057735729007 127.457257297324 0.97252753977737 -0.0401889903539003 0.921713853414396 1 0.923188 0.713771 0.849516 0.719001 GeneID:79937,Genbank:NM_033655.3,HGNC:HGNC:13834,MIM:610517 contactin associated protein like 3 GO:0005576,GO:0005886,GO:0007155,GO:0008037,GO:0016021 extracellular region|plasma membrane|cell adhesion|cell recognition|integral component of membrane CNTNAP3B 24.0980083742148 31.7193539574269 16.4766627910026 0.519451399076958 -0.944939320908338 0.114032125756959 1 0.20517 0.115465 0.0627057 0.0842599 GeneID:728577,Genbank:NM_001201380.2,HGNC:HGNC:32035 contactin associated protein like 3B GO:0007155,GO:0016021 cell adhesion|integral component of membrane CNTRL 61.0511580204585 48.9100706455116 73.1922453954055 1.49646574681695 0.58155925680937 0.113767966998587 1 0.135302 0.13018 0.239776 0.152862 GeneID:11064,Genbank:XM_017014227.2,HGNC:HGNC:1858,MIM:605496 centriolin GO:0000086,GO:0004713,GO:0005813,GO:0005829,GO:0010389,GO:0016020,GO:0051301,GO:0090543,GO:0097711,GO:0120103 G2/M transition of mitotic cell cycle|protein tyrosine kinase activity|centrosome|cytosol|regulation of G2/M transition of mitotic cell cycle|membrane|cell division|Flemming body|ciliary basal body-plasma membrane docking|centriolar subdistal appendage CNTROB 1845.01040902872 1769.98191532966 1920.03890272778 1.08477882519505 0.117400922557902 0.422328194426277 1 10.6865 11.8267 12.3075 12.1834 GeneID:116840,Genbank:XM_017024129.1,HGNC:HGNC:29616,MIM:611425 centrobin, centriole duplication and spindle assembly protein GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0019904,GO:0051299,GO:1902410 centrosome|centriole|cytosol|centriole replication|protein domain specific binding|centrosome separation|mitotic cytokinetic process COA1 2651.62504999782 2929.24593027705 2374.00416971859 0.810448909455018 -0.303206853498776 0.0279601180440002 0.668561867500627 4.14756 4.18247 3.26401 3.54291 GeneID:55744,Genbank:XM_017012416.2,HGNC:HGNC:21868,MIM:614769 cytochrome c oxidase assembly factor 1 homolog GO:0003723,GO:0003735,GO:0005739,GO:0005829,GO:0006412,GO:0022625,GO:0031305,GO:0032981,GO:0033617 RNA binding|structural constituent of ribosome|mitochondrion|cytosol|translation|cytosolic large ribosomal subunit|integral component of mitochondrial inner membrane|mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex IV assembly hsa04714 Thermogenesis COA3 1145.88475929635 1130.21960006638 1161.54991852632 1.02772055842785 0.0394480429614092 0.853371495258231 1 64.8765 72.7138 66.2578 77.7604 GeneID:28958,Genbank:NM_001040431.2,HGNC:HGNC:24990,MIM:614775 cytochrome c oxidase assembly factor 3 GO:0005739,GO:0031305,GO:0033617,GO:0070131 mitochondrion|integral component of mitochondrial inner membrane|mitochondrial respiratory chain complex IV assembly|positive regulation of mitochondrial translation hsa04714 Thermogenesis COA4 1491.59799083097 1612.79650781775 1370.3994738442 0.849703894571593 -0.234967917470211 0.163615001993791 1 10.6653 11.5908 8.55431 9.89885 GeneID:51287,Genbank:XM_017017884.1,HGNC:HGNC:24604,MIM:608016 cytochrome c oxidase assembly factor 4 homolog GO:0005758,GO:0033617 mitochondrial intermembrane space|mitochondrial respiratory chain complex IV assembly hsa04714 Thermogenesis COA5 406.028995191915 413.219125393443 398.838864990387 0.965199431683217 -0.0511010288032858 0.768175150075506 1 8.18842 9.3763 8.67066 8.61108 GeneID:493753,Genbank:NM_001008215.2,HGNC:HGNC:33848,MIM:613920 cytochrome c oxidase assembly factor 5 GO:0005739,GO:0033617 mitochondrion|mitochondrial respiratory chain complex IV assembly hsa04714 Thermogenesis COA6 683.564884116582 732.297532337242 634.832235895921 0.866904786459891 -0.206054546244548 0.203785910945093 1 18.6004 19.4903 15.0832 17.5925 GeneID:388753,Genbank:NM_001206641.2,HGNC:HGNC:18025,MIM:614772 cytochrome c oxidase assembly factor 6 hsa04714 Thermogenesis COA7 515.850580759719 555.788634740894 475.912526778543 0.856283300935816 -0.223839904293847 0.192479475568614 1 9.31479 9.99659 8.87491 8.11269 GeneID:65260,Genbank:NM_023077.2,HGNC:HGNC:25716,MIM:615623 cytochrome c oxidase assembly factor 7 (putative) GO:0005634,GO:0005739,GO:0005758 nucleus|mitochondrion|mitochondrial intermembrane space hsa04714 Thermogenesis COASY 2054.83909269553 1877.05557832808 2232.62260706299 1.18942807705866 0.250268036783705 0.0780618086536912 0.94157495521624 27.1457 28.1066 33.6781 33.5324 GeneID:80347,Genbank:NM_025233.6,HGNC:HGNC:29932,MIM:609855 Coenzyme A synthase GO:0004140,GO:0004595,GO:0005524,GO:0005654,GO:0005741,GO:0005759,GO:0005829,GO:0009108,GO:0015937,GO:0070062 dephospho-CoA kinase activity|pantetheine-phosphate adenylyltransferase activity|ATP binding|nucleoplasm|mitochondrial outer membrane|mitochondrial matrix|cytosol|coenzyme biosynthetic process|coenzyme A biosynthetic process|extracellular exosome hsa00770 Pantothenate and CoA biosynthesis COBL 167.44491105762 137.6305777083 197.25924440694 1.43325159053694 0.51929188005413 0.0323020973396246 0.712140594139387 0.509219 0.540369 0.79928 0.650086 GeneID:23242,Genbank:NM_001346443.1,HGNC:HGNC:22199,MIM:610317 cordon-bleu WH2 repeat protein GO:0000578,GO:0001726,GO:0001757,GO:0001843,GO:0001889,GO:0003785,GO:0005884,GO:0005886,GO:0005938,GO:0030041,GO:0030424,GO:0030425,GO:0030903,GO:0033504,GO:0043025,GO:0044294,GO:0044295,GO:0048471,GO:0048565,GO:0048669,GO:0051639,GO:1900006,GO:1900029 embryonic axis specification|ruffle|somite specification|neural tube closure|liver development|actin monomer binding|actin filament|plasma membrane|cell cortex|actin filament polymerization|axon|dendrite|notochord development|floor plate development|neuronal cell body|dendritic growth cone|axonal growth cone|perinuclear region of cytoplasm|digestive tract development|collateral sprouting in absence of injury|actin filament network formation|positive regulation of dendrite development|positive regulation of ruffle assembly COBLL1 173.288931761857 149.286430150799 197.291433372915 1.32156307290371 0.40224528066919 0.353327110000796 1 0.513331 0.492046 0.855867 0.508543 GeneID:22837,Genbank:NM_001278460.1,HGNC:HGNC:23571,MIM:610318 cordon-bleu WH2 repeat protein like 1 GO:0003785,GO:0030041,GO:0045296,GO:0051639,GO:0070062 actin monomer binding|actin filament polymerization|cadherin binding|actin filament network formation|extracellular exosome COG1 872.313492025663 853.429378513263 891.197605538064 1.04425466005236 0.0624735816327896 0.696770118046473 1 10.0641 10.4144 10.642 11.1146 GeneID:9382,Genbank:NM_018714.2,HGNC:HGNC:6545,MIM:606973 component of oligomeric golgi complex 1 GO:0000139,GO:0005794,GO:0006888,GO:0006891,GO:0007030,GO:0015031,GO:0017119,GO:0032588 Golgi membrane|Golgi apparatus|ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi organization|protein transport|Golgi transport complex|trans-Golgi network membrane COG2 703.035334624471 746.047940556517 660.022728692425 0.884692112681229 -0.176752633806118 0.275175392760789 1 9.04085 9.64797 7.99583 8.89585 GeneID:22796,Genbank:NM_007357.2,HGNC:HGNC:6546,MIM:606974 component of oligomeric golgi complex 2 GO:0000139,GO:0005795,GO:0005829,GO:0006888,GO:0006891,GO:0007030,GO:0008565,GO:0017119,GO:0032403,GO:0032588 Golgi membrane|Golgi stack|cytosol|ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi organization|protein transporter activity|Golgi transport complex|protein complex binding|trans-Golgi network membrane COG3 332.116787068599 345.310922930325 318.922651206873 0.923581126540915 -0.114689403070304 0.581019844073792 1 2.85674 2.51335 2.87425 2.20754 GeneID:83548,Genbank:NM_031431.3,HGNC:HGNC:18619,MIM:606975 component of oligomeric golgi complex 3 GO:0000139,GO:0005794,GO:0005801,GO:0005829,GO:0005886,GO:0006486,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0007030,GO:0008565,GO:0017119,GO:0032580,GO:0032588,GO:0033365,GO:0050821 Golgi membrane|Golgi apparatus|cis-Golgi network|cytosol|plasma membrane|protein glycosylation|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|Golgi organization|protein transporter activity|Golgi transport complex|Golgi cisterna membrane|trans-Golgi network membrane|protein localization to organelle|protein stabilization COG4 2021.22711540422 1866.0612680752 2176.39296273323 1.16630305765798 0.221942713899238 0.114204808712189 1 12.9483 12.4875 15.3313 15.2809 GeneID:25839,Genbank:NM_001195139.1,HGNC:HGNC:18620,MIM:606976 component of oligomeric golgi complex 4 GO:0000139,GO:0000301,GO:0006888,GO:0006890,GO:0007030,GO:0015031,GO:0017119,GO:0032588,GO:0042802,GO:0048213 Golgi membrane|retrograde transport, vesicle recycling within Golgi|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|Golgi organization|protein transport|Golgi transport complex|trans-Golgi network membrane|identical protein binding|Golgi vesicle prefusion complex stabilization COG5 1050.41844084731 1062.21331105219 1038.62357064243 0.977791899080617 -0.0324006420925839 0.862015845422932 1 5.20278 4.5461 5.0079 4.45648 GeneID:10466,Genbank:NM_181733.2,HGNC:HGNC:14857,MIM:606821 component of oligomeric golgi complex 5 GO:0000139,GO:0005654,GO:0005794,GO:0005829,GO:0006888,GO:0006891,GO:0015031,GO:0016020,GO:0017119,GO:0032588 Golgi membrane|nucleoplasm|Golgi apparatus|cytosol|ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|protein transport|membrane|Golgi transport complex|trans-Golgi network membrane COG6 266.205648284201 273.598836111989 258.812460456413 0.945955999427119 -0.0801550158518912 0.709638665785194 1 1.60699 1.67632 1.71725 1.2857 GeneID:57511,Genbank:NM_001145079.1,HGNC:HGNC:18621,MIM:606977 component of oligomeric golgi complex 6 GO:0000139,GO:0006888,GO:0006891,GO:0015031,GO:0017119,GO:0032588,GO:0070085 Golgi membrane|ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|protein transport|Golgi transport complex|trans-Golgi network membrane|glycosylation COG7 411.130213848804 405.474035511495 416.786392186112 1.02789909016085 0.0396986407280376 0.847165222252566 1 3.88745 4.14661 4.50681 4.17728 GeneID:91949,Genbank:NM_153603.3,HGNC:HGNC:18622,MIM:606978 component of oligomeric golgi complex 7 GO:0000139,GO:0005730,GO:0005794,GO:0006486,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0017119,GO:0032588,GO:0033365,GO:0034067,GO:0050821 Golgi membrane|nucleolus|Golgi apparatus|protein glycosylation|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|Golgi organization|Golgi transport complex|trans-Golgi network membrane|protein localization to organelle|protein localization to Golgi apparatus|protein stabilization COG8 681.254178633414 698.627701427094 663.880655839734 0.950263859396956 -0.0735999332453232 0.660494917820342 1 16.7773 17.6877 15.6605 17.9496 GeneID:84342,Genbank:NM_032382.4,HGNC:HGNC:18623,MIM:606979 component of oligomeric golgi complex 8 GO:0000139,GO:0005794,GO:0006888,GO:0006891,GO:0015031,GO:0016020,GO:0017119,GO:0032588 Golgi membrane|Golgi apparatus|ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|protein transport|membrane|Golgi transport complex|trans-Golgi network membrane COIL 523.218520854069 539.980871363565 506.456170344574 0.93791502107411 -0.0924708802797217 0.610701512690364 1 7.65407 7.24376 7.53255 6.47772 GeneID:8161,Genbank:NM_004645.2,HGNC:HGNC:2184,MIM:600272 coilin GO:0001650,GO:0005634,GO:0005654,GO:0005730,GO:0008022,GO:0015030,GO:0016020,GO:0016604,GO:0042802 fibrillar center|nucleus|nucleoplasm|nucleolus|protein C-terminus binding|Cajal body|membrane|nuclear body|identical protein binding COL10A1 1.48878925781767 2.00831188251439 0.969266633120943 0.482627544835033 -1.05101783854861 0.812641228941161 1 0.00352578 0.0102791 0 0 GeneID:1300,Genbank:XM_011535432.3,HGNC:HGNC:2185,MIM:120110 collagen type X alpha 1 chain GO:0001501,GO:0005576,GO:0005578,GO:0005581,GO:0005788,GO:0005938,GO:0030198,GO:0030574,GO:0046872 skeletal system development|extracellular region|proteinaceous extracellular matrix|collagen trimer|endoplasmic reticulum lumen|cell cortex|extracellular matrix organization|collagen catabolic process|metal ion binding hsa04974 Protein digestion and absorption COL11A1 744.877505566757 687.133511117156 802.621500016359 1.16807212431168 0.224129358271233 0.230283844238846 1 2.46999 2.12479 3.00117 2.37952 GeneID:1301,Genbank:NM_001190709.1,HGNC:HGNC:2186,MIM:120280 collagen type XI alpha 1 chain GO:0001502,GO:0001503,GO:0002063,GO:0005201,GO:0005576,GO:0005592,GO:0005615,GO:0005788,GO:0006029,GO:0007601,GO:0007605,GO:0030198,GO:0030199,GO:0030574,GO:0030674,GO:0035987,GO:0035989,GO:0042472,GO:0046872,GO:0048704,GO:0050840,GO:0050910,GO:0055010 cartilage condensation|ossification|chondrocyte development|extracellular matrix structural constituent|extracellular region|collagen type XI trimer|extracellular space|endoplasmic reticulum lumen|proteoglycan metabolic process|visual perception|sensory perception of sound|extracellular matrix organization|collagen fibril organization|collagen catabolic process|protein binding, bridging|endodermal cell differentiation|tendon development|inner ear morphogenesis|metal ion binding|embryonic skeletal system morphogenesis|extracellular matrix binding|detection of mechanical stimulus involved in sensory perception of sound|ventricular cardiac muscle tissue morphogenesis hsa04974 Protein digestion and absorption COL11A2 13.5096836599791 12.4821077672508 14.5372595527073 1.16464781620045 0.219893756908833 0.800521406696827 1 0.0410769 0.0361625 0.0382463 0.0518375 GeneID:1302,Genbank:XM_017010250.1,HGNC:HGNC:2187,MIM:120290 collagen type XI alpha 2 chain hsa04974 Protein digestion and absorption COL12A1 7610.20528522959 7727.50808934699 7492.90248111219 0.969640198946123 -0.0444785841767028 0.8937698758618 1 18.1134 17.0285 21.5286 12.9636 GeneID:1303,Genbank:XM_011535436.2,HGNC:HGNC:2188,MIM:120320 collagen type XII alpha 1 chain GO:0001501,GO:0005576,GO:0005595,GO:0005615,GO:0005788,GO:0007155,GO:0030020,GO:0030199,GO:0030574,GO:0031012,GO:0035987,GO:0070062,GO:1903561 skeletal system development|extracellular region|collagen type XII trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|extracellular matrix structural constituent conferring tensile strength|collagen fibril organization|collagen catabolic process|extracellular matrix|endodermal cell differentiation|extracellular exosome|extracellular vesicle hsa04974 Protein digestion and absorption COL13A1 177.887177144687 181.303750411444 174.47060387793 0.962311058000692 -0.0554247879001639 0.832926587081674 1 1.11629 0.929 1.3172 0.975305 GeneID:1305,Genbank:XM_011539292.3,HGNC:HGNC:2190,MIM:120350 collagen type XIII alpha 1 chain GO:0001763,GO:0001958,GO:0005576,GO:0005600,GO:0005788,GO:0005886,GO:0005911,GO:0007160,GO:0008201,GO:0030154,GO:0030198,GO:0030574,GO:0045211,GO:0098609 morphogenesis of a branching structure|endochondral ossification|extracellular region|collagen type XIII trimer|endoplasmic reticulum lumen|plasma membrane|cell-cell junction|cell-matrix adhesion|heparin binding|cell differentiation|extracellular matrix organization|collagen catabolic process|postsynaptic membrane|cell-cell adhesion hsa04974 Protein digestion and absorption COL14A1 622.330061957974 555.490668437676 689.169455478272 1.24064992381703 0.311096085313361 0.0626089772317007 0.892209508796134 1.78813 1.94382 2.50379 2.19476 GeneID:7373,Genbank:XM_017013809.2,HGNC:HGNC:2191,MIM:120324 collagen type XIV alpha 1 chain GO:0003723,GO:0005201,GO:0005518,GO:0005576,GO:0005578,GO:0005581,GO:0005596,GO:0005615,GO:0005788,GO:0030198,GO:0030199,GO:0030674,GO:0070062,GO:0098609 RNA binding|extracellular matrix structural constituent|collagen binding|extracellular region|proteinaceous extracellular matrix|collagen trimer|collagen type XIV trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix organization|collagen fibril organization|protein binding, bridging|extracellular exosome|cell-cell adhesion hsa04974 Protein digestion and absorption COL15A1 2.02982347017177 3.57457863775636 0.48506830258717 0.135699435302291 -2.88151337772882 0.310086678524488 1 0.021209 0.0191533 0.00664565 0 GeneID:1306,Genbank:XM_011518214.2,HGNC:HGNC:2192,MIM:120325 collagen type XV alpha 1 chain GO:0001525,GO:0005198,GO:0005576,GO:0005582,GO:0005615,GO:0005788,GO:0007155,GO:0007165,GO:0016021,GO:0030154,GO:0030574,GO:0031012,GO:0070062 angiogenesis|structural molecule activity|extracellular region|collagen type XV trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|signal transduction|integral component of membrane|cell differentiation|collagen catabolic process|extracellular matrix|extracellular exosome hsa04974 Protein digestion and absorption COL16A1 41.8162963137566 41.9628271238466 41.6697655036666 0.993016161201078 -0.0101108972798169 1 1 0.146301 0.195174 0.142137 0.183174 GeneID:1307,Genbank:NM_001856.3,HGNC:HGNC:2193,MIM:120326 collagen type XVI alpha 1 chain COL17A1 2065.98074764081 2101.36790825047 2030.59358703115 0.966319880996827 -0.0494272512344931 0.726822137671448 1 10.5069 10.2501 10.3677 9.90912 GeneID:1308,Genbank:NM_000494.3,HGNC:HGNC:2194,MIM:113811 collagen type XVII alpha 1 chain GO:0005576,GO:0005581,GO:0005604,GO:0005788,GO:0005886,GO:0005887,GO:0005911,GO:0007160,GO:0008544,GO:0030056,GO:0031581,GO:0050776 extracellular region|collagen trimer|basement membrane|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|cell-cell junction|cell-matrix adhesion|epidermis development|hemidesmosome|hemidesmosome assembly|regulation of immune response hsa04974 Protein digestion and absorption COL18A1 951.236226109559 1137.72455857491 764.74789364421 0.672173144088689 -0.573095192324847 0.000174072424856247 0.0324179529825308 6.29062 6.76189 4.45746 4.31712 GeneID:80781,Genbank:NM_130445.3,HGNC:HGNC:2195,MIM:120328 collagen type XVIII alpha 1 chain GO:0001525,GO:0001886,GO:0005198,GO:0005576,GO:0005581,GO:0005604,GO:0005615,GO:0005788,GO:0007155,GO:0007601,GO:0008284,GO:0008285,GO:0009887,GO:0030198,GO:0030335,GO:0030574,GO:0031012,GO:0042493,GO:0042802,GO:0046872,GO:0051599,GO:0070062,GO:2000353 angiogenesis|endothelial cell morphogenesis|structural molecule activity|extracellular region|collagen trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|cell adhesion|visual perception|positive regulation of cell proliferation|negative regulation of cell proliferation|animal organ morphogenesis|extracellular matrix organization|positive regulation of cell migration|collagen catabolic process|extracellular matrix|response to drug|identical protein binding|metal ion binding|response to hydrostatic pressure|extracellular exosome|positive regulation of endothelial cell apoptotic process hsa04974 Protein digestion and absorption COL19A1 4.67651416629543 4.50669516698614 4.84633316560471 1.07536298463375 0.104823718176273 1 1 0 0.0119731 0.00901365 0.00839327 GeneID:1310,Genbank:XM_017010256.1,HGNC:HGNC:2196,MIM:120165 collagen type XIX alpha 1 chain GO:0001501,GO:0005201,GO:0005576,GO:0005578,GO:0005581,GO:0005788,GO:0007155,GO:0007519,GO:0030154,GO:0030198,GO:0030574,GO:0030674,GO:0098609 skeletal system development|extracellular matrix structural constituent|extracellular region|proteinaceous extracellular matrix|collagen trimer|endoplasmic reticulum lumen|cell adhesion|skeletal muscle tissue development|cell differentiation|extracellular matrix organization|collagen catabolic process|protein binding, bridging|cell-cell adhesion COL1A1 271.338562185316 296.977167581033 245.699956789598 0.827336184767662 -0.273454412960691 0.198231238578824 1 2.05219 1.69182 1.48362 1.57504 GeneID:1277,Genbank:XM_005257058.4,HGNC:HGNC:2197,MIM:120150 collagen type I alpha 1 chain hsa04151,hsa04510,hsa04512,hsa04611,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Platelet activation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection COL1A2 31534.7880825101 29121.9121265937 33947.6640384265 1.16570862142758 0.221207219966693 0.0860046894487147 0.964561165794104 226.694 228.606 288.667 251.497 GeneID:1278,Genbank:NM_000089.3,HGNC:HGNC:2198,MIM:120160 collagen type I alpha 2 chain hsa04151,hsa04510,hsa04512,hsa04611,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Platelet activation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection COL21A1 225.086715159978 193.728023248902 256.445407071055 1.32373934741271 0.404619074399521 0.46028091704559 1 1.04207 0.959734 1.89914 0.959561 GeneID:81578,Genbank:NM_001318752.1,HGNC:HGNC:17025,MIM:610002 collagen type XXI alpha 1 chain GO:0005576,GO:0005578,GO:0005581,GO:0005788,GO:0005829 extracellular region|proteinaceous extracellular matrix|collagen trimer|endoplasmic reticulum lumen|cytosol hsa04974,hsa05205 Protein digestion and absorption|Proteoglycans in cancer COL22A1 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.00335606 0.00307655 0 0 GeneID:169044,Genbank:XM_017013150.2,HGNC:HGNC:22989,MIM:610026 collagen type XXII alpha 1 chain GO:0005576,GO:0005578,GO:0005581,GO:0005788 extracellular region|proteinaceous extracellular matrix|collagen trimer|endoplasmic reticulum lumen hsa04974 Protein digestion and absorption COL23A1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00746052 GeneID:91522,Genbank:NM_173465.3,HGNC:HGNC:22990,MIM:610043 collagen type XXIII alpha 1 chain GO:0005581,GO:0005788,GO:0005886,GO:0016021 collagen trimer|endoplasmic reticulum lumen|plasma membrane|integral component of membrane COL24A1 13.3547286651305 10.2336645113117 16.4757928189492 1.60996022497492 0.687025046140962 0.400450171593686 1 0.0189605 0.0289631 0.0365357 0.0475359 GeneID:255631,Genbank:XM_017000924.2,HGNC:HGNC:20821,MIM:610025 collagen type XXIV alpha 1 chain GO:0002244,GO:0005201,GO:0005576,GO:0005578,GO:0005581,GO:0005788 hematopoietic progenitor cell differentiation|extracellular matrix structural constituent|extracellular region|proteinaceous extracellular matrix|collagen trimer|endoplasmic reticulum lumen hsa04974 Protein digestion and absorption COL25A1 3.19109643021626 2.98845468642911 3.3937381740034 1.13561640717349 0.183475598113677 1 1 0.00322456 0.01238 0.012442 0.00579228 GeneID:84570,Genbank:XM_017008735.1,HGNC:HGNC:18603,MIM:610004 collagen type XXV alpha 1 chain GO:0001540,GO:0005576,GO:0005581,GO:0005615,GO:0005788,GO:0005886,GO:0005887,GO:0008201,GO:0016021,GO:0030574,GO:0060385 amyloid-beta binding|extracellular region|collagen trimer|extracellular space|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|heparin binding|integral component of membrane|collagen catabolic process|axonogenesis involved in innervation COL26A1 1.24669009255078 2.00831188251439 0.48506830258717 0.241530365283637 -2.04972351828911 0.634396538962021 1 0 0.0331844 0.0118044 0 GeneID:136227,Genbank:XM_017011743.1,HGNC:HGNC:18038,MIM:608927 collagen type XXVI alpha 1 chain GO:0005576,GO:0005578,GO:0005581,GO:0005788,GO:0005794,GO:0005886,GO:0010811,GO:0030574,GO:0031012 extracellular region|proteinaceous extracellular matrix|collagen trimer|endoplasmic reticulum lumen|Golgi apparatus|plasma membrane|positive regulation of cell-substrate adhesion|collagen catabolic process|extracellular matrix COL27A1 305.511146608728 325.565005028831 285.457288188625 0.876805810757659 -0.189670735544809 0.334390958174787 1 1.11083 1.18153 1.04016 0.860545 GeneID:85301,Genbank:XM_011519138.2,HGNC:HGNC:22986,MIM:608461 collagen type XXVII alpha 1 chain GO:0003431,GO:0005201,GO:0005576,GO:0005583,GO:0005788,GO:0030198,GO:0046872 growth plate cartilage chondrocyte development|extracellular matrix structural constituent|extracellular region|fibrillar collagen trimer|endoplasmic reticulum lumen|extracellular matrix organization|metal ion binding hsa04974 Protein digestion and absorption COL28A1 0.99578132014851 0.538097676642304 1.45346496365472 2.70111733751434 1.43355631240266 0.835241087836065 1 0 0 0.00274302 0.0051095 GeneID:340267,Genbank:XM_017012132.2,HGNC:HGNC:22442,MIM:609996 collagen type XXVIII alpha 1 chain GO:0004867,GO:0005576,GO:0005581,GO:0005604,GO:0005788,GO:0007155,GO:0031012 serine-type endopeptidase inhibitor activity|extracellular region|collagen trimer|basement membrane|endoplasmic reticulum lumen|cell adhesion|extracellular matrix COL2A1 3.7767853955168 4.16070258908361 3.39286820195 0.815455594171002 -0.294321778113983 0.953622931919326 1 0.0296367 0.0194684 0.0207081 0.00643792 GeneID:1280,Genbank:NM_033150.2,HGNC:HGNC:2200,MIM:120140 collagen type II alpha 1 chain GO:0001501,GO:0001502,GO:0001894,GO:0001958,GO:0002062,GO:0003007,GO:0005576,GO:0005585,GO:0005604,GO:0005615,GO:0005788,GO:0006029,GO:0007417,GO:0007601,GO:0007605,GO:0010468,GO:0030020,GO:0030198,GO:0030199,GO:0030574,GO:0030903,GO:0031012,GO:0042289,GO:0042472,GO:0042802,GO:0046872,GO:0048407,GO:0050776,GO:0051216,GO:0060021,GO:0060174,GO:0060272,GO:0060351,GO:0071599,GO:0071773,GO:2001240 skeletal system development|cartilage condensation|tissue homeostasis|endochondral ossification|chondrocyte differentiation|heart morphogenesis|extracellular region|collagen type II trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|proteoglycan metabolic process|central nervous system development|visual perception|sensory perception of sound|regulation of gene expression|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization|collagen fibril organization|collagen catabolic process|notochord development|extracellular matrix|MHC class II protein binding|inner ear morphogenesis|identical protein binding|metal ion binding|platelet-derived growth factor binding|regulation of immune response|cartilage development|palate development|limb bud formation|embryonic skeletal joint morphogenesis|cartilage development involved in endochondral bone morphogenesis|otic vesicle development|cellular response to BMP stimulus|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa04151,hsa04510,hsa04512,hsa04974,hsa05165 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL3A1 1.50823428181664 1.07619535328461 1.94027321034868 1.80290056487129 0.850319830201774 0.866997324863217 1 0.0142734 0 0.027066 0 GeneID:1281,Genbank:NM_000090.3,HGNC:HGNC:2201,MIM:120180 collagen type III alpha 1 chain hsa04611,hsa04926,hsa04933,hsa04974,hsa05146 Platelet activation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis COL4A1 3084.00516203675 3284.91497923253 2883.09534484097 0.87767731069696 -0.188237482949102 0.170783788553622 1 6.99545 6.76865 6.2471 5.84182 GeneID:1282,Genbank:NM_001845.5,HGNC:HGNC:2202,MIM:120130 collagen type IV alpha 1 chain GO:0001569,GO:0005201,GO:0005576,GO:0005587,GO:0005604,GO:0005615,GO:0005788,GO:0007420,GO:0007528,GO:0030023,GO:0030198,GO:0030574,GO:0030855,GO:0031012,GO:0038063,GO:0048407,GO:0048514,GO:0061304,GO:0061333,GO:0071230,GO:0071711 branching involved in blood vessel morphogenesis|extracellular matrix structural constituent|extracellular region|collagen type IV trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|brain development|neuromuscular junction development|extracellular matrix constituent conferring elasticity|extracellular matrix organization|collagen catabolic process|epithelial cell differentiation|extracellular matrix|collagen-activated tyrosine kinase receptor signaling pathway|platelet-derived growth factor binding|blood vessel morphogenesis|retinal blood vessel morphogenesis|renal tubule morphogenesis|cellular response to amino acid stimulus|basement membrane organization hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A2 10406.5600419941 10596.2462928193 10216.8737911689 0.964197462840451 -0.0525994614115641 0.678883691655106 1 48.3309 48.2616 50.8991 44.3718 GeneID:1284,Genbank:NM_001846.3,HGNC:HGNC:2203,MIM:120090 collagen type IV alpha 2 chain GO:0001525,GO:0005201,GO:0005576,GO:0005587,GO:0005788,GO:0006351,GO:0007568,GO:0014823,GO:0016525,GO:0030198,GO:0030574,GO:0031012,GO:0035987,GO:0038063,GO:0070062,GO:0071560 angiogenesis|extracellular matrix structural constituent|extracellular region|collagen type IV trimer|endoplasmic reticulum lumen|transcription, DNA-templated|aging|response to activity|negative regulation of angiogenesis|extracellular matrix organization|collagen catabolic process|extracellular matrix|endodermal cell differentiation|collagen-activated tyrosine kinase receptor signaling pathway|extracellular exosome|cellular response to transforming growth factor beta stimulus hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A2-AS2 15.7615080323156 16.0086601303222 15.5143559343089 0.969122700339106 -0.0452487584894234 1 1 0 0 0 0 GeneID:100129836,Genbank:NM_001267044.1,HGNC:HGNC:39849 COL4A2 antisense 2 COL4A3 29.4666779074318 27.9046439462458 31.0287118686177 1.11195512576294 0.153098567606759 0.845076941030302 1 0.0911992 0.0674903 0.137698 0.0575359 GeneID:1285,Genbank:NM_000091.4,HGNC:HGNC:2204,MIM:120070 collagen type IV alpha 3 chain GO:0005178,GO:0005198,GO:0005201,GO:0005576,GO:0005587,GO:0005604,GO:0005783,GO:0005788,GO:0006919,GO:0007155,GO:0007166,GO:0007605,GO:0008015,GO:0008191,GO:0008283,GO:0008285,GO:0016525,GO:0030198,GO:0030574,GO:0032836,GO:0038063,GO:0043231,GO:0072577 integrin binding|structural molecule activity|extracellular matrix structural constituent|extracellular region|collagen type IV trimer|basement membrane|endoplasmic reticulum|endoplasmic reticulum lumen|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell adhesion|cell surface receptor signaling pathway|sensory perception of sound|blood circulation|metalloendopeptidase inhibitor activity|cell proliferation|negative regulation of cell proliferation|negative regulation of angiogenesis|extracellular matrix organization|collagen catabolic process|glomerular basement membrane development|collagen-activated tyrosine kinase receptor signaling pathway|intracellular membrane-bounded organelle|endothelial cell apoptotic process hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A3BP 414.829184623792 430.273537910871 399.384831336712 0.928211465840696 -0.107474576209957 0.740251746002292 1 2.84946 2.18252 2.89946 1.96202 GeneID:10087,Genbank:XM_017008919.2,HGNC:HGNC:2205,MIM:604677 collagen type IV alpha 3 binding protein GO:0000902,GO:0001701,GO:0003007,GO:0005622,GO:0005654,GO:0005739,GO:0005789,GO:0005794,GO:0005829,GO:0006672,GO:0006936,GO:0006955,GO:0007029,GO:0007165,GO:0008283,GO:0016301,GO:0030148,GO:0034976,GO:0035621,GO:0055088,GO:0070273,GO:0070584,GO:0097001,GO:0120012,GO:0120017 cell morphogenesis|in utero embryonic development|heart morphogenesis|intracellular|nucleoplasm|mitochondrion|endoplasmic reticulum membrane|Golgi apparatus|cytosol|ceramide metabolic process|muscle contraction|immune response|endoplasmic reticulum organization|signal transduction|cell proliferation|kinase activity|sphingolipid biosynthetic process|response to endoplasmic reticulum stress|ER to Golgi ceramide transport|lipid homeostasis|phosphatidylinositol-4-phosphate binding|mitochondrion morphogenesis|ceramide binding|intermembrane sphingolipid transfer|intermembrane ceramide transfer activity COL4A4 58.5627319962805 59.9317728619982 57.1936911305628 0.954313353323616 -0.0674650350950494 0.87564786405591 1 0.133741 0.124021 0.157393 0.0875144 GeneID:1286,Genbank:XM_011510565.2,HGNC:HGNC:2206,MIM:120131 collagen type IV alpha 4 chain GO:0005201,GO:0005576,GO:0005587,GO:0005605,GO:0005788,GO:0030198,GO:0030574,GO:0032836 extracellular matrix structural constituent|extracellular region|collagen type IV trimer|basal lamina|endoplasmic reticulum lumen|extracellular matrix organization|collagen catabolic process|glomerular basement membrane development hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A5 1469.78176771075 1451.660086124 1487.90344929751 1.02496683866971 0.0355772341593246 0.800584797074644 1 5.10596 5.19012 5.70903 4.87341 GeneID:1287,Genbank:NM_033380.2,HGNC:HGNC:2207,MIM:303630 collagen type IV alpha 5 chain hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL4A6 206.86033800279 184.984190253678 228.736485751902 1.23651910705571 0.30628453284677 0.177452030751088 1 0.569061 0.594267 0.70499 0.802306 GeneID:1288,Genbank:NM_001847.3,HGNC:HGNC:2208,MIM:303631 collagen type IV alpha 6 chain GO:0005201,GO:0005576,GO:0005587,GO:0005788,GO:0007155,GO:0030198,GO:0030574 extracellular matrix structural constituent|extracellular region|collagen type IV trimer|endoplasmic reticulum lumen|cell adhesion|extracellular matrix organization|collagen catabolic process hsa04151,hsa04510,hsa04512,hsa04926,hsa04933,hsa04974,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Protein digestion and absorption|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer COL5A1 6370.4820952857 6507.03927743474 6233.92491313666 0.958027859883189 -0.061860484091991 0.634418162706808 1 20.7684 20.2606 20.96 19.2033 GeneID:1289,Genbank:XM_017014266.2,HGNC:HGNC:2209,MIM:120215 collagen type V alpha 1 chain GO:0001568,GO:0003007,GO:0005178,GO:0005201,GO:0005576,GO:0005588,GO:0005604,GO:0005788,GO:0007155,GO:0008201,GO:0016477,GO:0030198,GO:0030199,GO:0030574,GO:0031012,GO:0032964,GO:0035313,GO:0035989,GO:0043394,GO:0043588,GO:0045112,GO:0046872,GO:0048407,GO:0048592,GO:0051128,GO:0070062,GO:0097435,GO:1903225 blood vessel development|heart morphogenesis|integrin binding|extracellular matrix structural constituent|extracellular region|collagen type V trimer|basement membrane|endoplasmic reticulum lumen|cell adhesion|heparin binding|cell migration|extracellular matrix organization|collagen fibril organization|collagen catabolic process|extracellular matrix|collagen biosynthetic process|wound healing, spreading of epidermal cells|tendon development|proteoglycan binding|skin development|integrin biosynthetic process|metal ion binding|platelet-derived growth factor binding|eye morphogenesis|regulation of cellular component organization|extracellular exosome|supramolecular fiber organization|negative regulation of endodermal cell differentiation hsa04974 Protein digestion and absorption COL5A2 4874.26294769759 4802.78069689374 4945.74519850143 1.02976702677683 0.0423179807761277 0.737673312108515 1 20.4644 19.5977 22.0098 19.9744 GeneID:1290,Genbank:NM_000393.4,HGNC:HGNC:2210,MIM:120190 collagen type V alpha 2 chain GO:0001501,GO:0001503,GO:0005201,GO:0005576,GO:0005588,GO:0005615,GO:0005788,GO:0030198,GO:0030199,GO:0030574,GO:0031012,GO:0043588,GO:0046332,GO:0046872,GO:0048592,GO:0071230,GO:1903225 skeletal system development|ossification|extracellular matrix structural constituent|extracellular region|collagen type V trimer|extracellular space|endoplasmic reticulum lumen|extracellular matrix organization|collagen fibril organization|collagen catabolic process|extracellular matrix|skin development|SMAD binding|metal ion binding|eye morphogenesis|cellular response to amino acid stimulus|negative regulation of endodermal cell differentiation hsa04974 Protein digestion and absorption COL5A3 1.24375355683899 1.51824048055703 0.969266633120943 0.638414431398462 -0.647434830746163 0.97445271569056 1 0.00602844 0.00527704 0.0056045 0.00525985 GeneID:50509,Genbank:XM_011528042.2,HGNC:HGNC:14864,MIM:120216 collagen type V alpha 3 chain GO:0005201,GO:0005518,GO:0005576,GO:0005588,GO:0005788,GO:0007160,GO:0008201,GO:0030198,GO:0030199,GO:0030574,GO:0031012,GO:0043394,GO:0043588,GO:0070062 extracellular matrix structural constituent|collagen binding|extracellular region|collagen type V trimer|endoplasmic reticulum lumen|cell-matrix adhesion|heparin binding|extracellular matrix organization|collagen fibril organization|collagen catabolic process|extracellular matrix|proteoglycan binding|skin development|extracellular exosome hsa04974 Protein digestion and absorption COL6A1 8195.74273719818 8973.32030904642 7418.16516534995 0.826691225751895 -0.27457952033783 0.0330365609313053 0.717059810541268 76.4594 81.1394 67.7007 65.5758 GeneID:1291,Genbank:NM_001848.2,HGNC:HGNC:2211,MIM:120220 collagen type VI alpha 1 chain GO:0001649,GO:0005576,GO:0005578,GO:0005589,GO:0005765,GO:0005788,GO:0007155,GO:0016020,GO:0030198,GO:0030574,GO:0031012,GO:0035987,GO:0042383,GO:0043234,GO:0048407,GO:0070062,GO:0070208,GO:0071230 osteoblast differentiation|extracellular region|proteinaceous extracellular matrix|collagen type VI trimer|lysosomal membrane|endoplasmic reticulum lumen|cell adhesion|membrane|extracellular matrix organization|collagen catabolic process|extracellular matrix|endodermal cell differentiation|sarcolemma|protein complex|platelet-derived growth factor binding|extracellular exosome|protein heterotrimerization|cellular response to amino acid stimulus hsa04151,hsa04510,hsa04512,hsa04974,hsa05165 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL6A2 6134.47634903617 6315.57560810201 5953.37708997033 0.942649959305841 -0.0852059504184824 0.504737311448726 1 45.9008 49.5458 44.2257 47.4897 GeneID:1292,Genbank:NM_001849.3,HGNC:HGNC:2212,MIM:120240 collagen type VI alpha 2 chain GO:0005576,GO:0005578,GO:0005581,GO:0005615,GO:0005788,GO:0007155,GO:0009749,GO:0030198,GO:0030574,GO:0031012,GO:0042383,GO:0043234,GO:0070062,GO:0070208,GO:1903561 extracellular region|proteinaceous extracellular matrix|collagen trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|response to glucose|extracellular matrix organization|collagen catabolic process|extracellular matrix|sarcolemma|protein complex|extracellular exosome|protein heterotrimerization|extracellular vesicle hsa04151,hsa04510,hsa04512,hsa04974,hsa05165 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL6A3 34.687054455318 34.9577486723887 34.4163602382473 0.984513063492303 -0.0225177455299352 1 1 0.0868709 0.0817328 0.0976917 0.0675554 GeneID:1293,Genbank:NM_057166.4,HGNC:HGNC:2213,MIM:120250 collagen type VI alpha 3 chain GO:0004867,GO:0005576,GO:0005578,GO:0005589,GO:0005615,GO:0005788,GO:0007155,GO:0007517,GO:0030198,GO:0030574,GO:0031012,GO:0042383,GO:0070062,GO:1903561 serine-type endopeptidase inhibitor activity|extracellular region|proteinaceous extracellular matrix|collagen type VI trimer|extracellular space|endoplasmic reticulum lumen|cell adhesion|muscle organ development|extracellular matrix organization|collagen catabolic process|extracellular matrix|sarcolemma|extracellular exosome|extracellular vesicle hsa04151,hsa04510,hsa04512,hsa04974,hsa05165 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL7A1 152.190022529056 164.795210224056 139.584834834057 0.847019974939056 -0.239532102418771 0.357139274294923 1 0.418847 0.374202 0.381102 0.3201 GeneID:1294,Genbank:XM_017005688.1,HGNC:HGNC:2214,MIM:120120 collagen type VII alpha 1 chain GO:0000139,GO:0004867,GO:0005576,GO:0005590,GO:0005604,GO:0005615,GO:0005788,GO:0006888,GO:0007155,GO:0008544,GO:0030134,GO:0030198,GO:0030574,GO:0033116,GO:0035987,GO:0042802,GO:0048208 Golgi membrane|serine-type endopeptidase inhibitor activity|extracellular region|collagen type VII trimer|basement membrane|extracellular space|endoplasmic reticulum lumen|ER to Golgi vesicle-mediated transport|cell adhesion|epidermis development|COPII-coated ER to Golgi transport vesicle|extracellular matrix organization|collagen catabolic process|endoplasmic reticulum-Golgi intermediate compartment membrane|endodermal cell differentiation|identical protein binding|COPII vesicle coating hsa04974 Protein digestion and absorption COL8A1 316.505816328355 301.033025966493 331.978606690217 1.10279795920853 0.14116850267251 0.486255196886119 1 2.64721 2.82903 3.16255 2.94449 GeneID:1295,Genbank:NM_001850.4,HGNC:HGNC:2215,MIM:120251 collagen type VIII alpha 1 chain GO:0001525,GO:0005576,GO:0005591,GO:0005788,GO:0007155,GO:0010811,GO:0030198,GO:0030574,GO:0031012,GO:0035987,GO:0048593,GO:0050673,GO:0070062 angiogenesis|extracellular region|collagen type VIII trimer|endoplasmic reticulum lumen|cell adhesion|positive regulation of cell-substrate adhesion|extracellular matrix organization|collagen catabolic process|extracellular matrix|endodermal cell differentiation|camera-type eye morphogenesis|epithelial cell proliferation|extracellular exosome COL8A2 17.865329111698 20.7074603960482 15.0231978273479 0.725496876005856 -0.462958692835954 0.525152729202363 1 0.181981 0.13563 0.127047 0.119389 GeneID:1296,Genbank:NM_001294347.1,HGNC:HGNC:2216,MIM:120252 collagen type VIII alpha 2 chain GO:0001525,GO:0005201,GO:0005576,GO:0005578,GO:0005581,GO:0005604,GO:0005788,GO:0030198,GO:0030574,GO:0030674,GO:0048593,GO:0050673,GO:0098609 angiogenesis|extracellular matrix structural constituent|extracellular region|proteinaceous extracellular matrix|collagen trimer|basement membrane|endoplasmic reticulum lumen|extracellular matrix organization|collagen catabolic process|protein binding, bridging|camera-type eye morphogenesis|epithelial cell proliferation|cell-cell adhesion COL9A2 103.63453491902 92.9008269620884 114.368242875951 1.23107884629082 0.299923164348771 0.356891449572988 1 0.565853 0.730667 0.745191 0.845512 GeneID:1298,Genbank:XM_017000332.1,HGNC:HGNC:2218,MIM:120260 collagen type IX alpha 2 chain GO:0001501,GO:0005576,GO:0005578,GO:0005594,GO:0005788,GO:0030020,GO:0030198 skeletal system development|extracellular region|proteinaceous extracellular matrix|collagen type IX trimer|endoplasmic reticulum lumen|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization hsa04151,hsa04510,hsa04512,hsa04974,hsa05165 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COL9A3 76.0117447698921 72.0776967064545 79.9457928333297 1.10916131461469 0.149469203975759 0.741174920015181 1 0.859472 0.954618 0.757312 1.16351 GeneID:1299,Genbank:NM_001853.3,HGNC:HGNC:2219,MIM:120270 collagen type IX alpha 3 chain GO:0005576,GO:0005578,GO:0005594,GO:0005788,GO:0008584,GO:0008585,GO:0030020,GO:0030198 extracellular region|proteinaceous extracellular matrix|collagen type IX trimer|endoplasmic reticulum lumen|male gonad development|female gonad development|extracellular matrix structural constituent conferring tensile strength|extracellular matrix organization hsa04151,hsa04510,hsa04512,hsa04974,hsa05165 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Protein digestion and absorption|Human papillomavirus infection COLCA1 1.02523254288787 1.56626675524197 0.484198330533773 0.309141676482158 -1.69365993276169 0.789571303159055 1 0.00795948 0.00738129 0 0.00706378 GeneID:399948,Genbank:NM_001302644.1,HGNC:HGNC:33789,MIM:615693 colorectal cancer associated 1 GO:0016020,GO:0016021 membrane|integral component of membrane COLCA2 1.5393170821877 2.59443583384164 0.484198330533773 0.186629526241476 -2.42175084507305 0.49977085294748 1 0 0.0220743 0 0.0106642 GeneID:120376,Genbank:XM_017017196.2,HGNC:HGNC:26978,MIM:615694 colorectal cancer associated 2 GO:0005737 cytoplasm COLEC10 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:10584,Genbank:NM_001324095.1,HGNC:HGNC:2220,MIM:607620 collectin subfamily member 10 COLEC11 13.7150677073815 14.3463408257104 13.0837945890526 0.911995243107907 -0.132901795456261 0.910250553940532 1 0.246411 0.199033 0.168014 0.19564 GeneID:78989,Genbank:NM_199235.2,HGNC:HGNC:17213,MIM:612502 collectin subfamily member 11 hsa04145 Phagosome COLEC12 1.77934968379619 2.10436443188427 1.45433493570811 0.69110412325582 -0.533025008314132 0.969273063831792 1 0.0327551 0.0100887 0.020738 0.00965671 GeneID:81035,Genbank:NM_130386.2,HGNC:HGNC:16016,MIM:607621 collectin subfamily member 12 GO:0005044,GO:0005534,GO:0005581,GO:0005886,GO:0006898,GO:0006910,GO:0006952,GO:0008329,GO:0009756,GO:0016021,GO:0030169,GO:0030666,GO:0034138,GO:0045087,GO:0046872,GO:0050776,GO:0051260,GO:0060355,GO:0070062,GO:0071360 scavenger receptor activity|galactose binding|collagen trimer|plasma membrane|receptor-mediated endocytosis|phagocytosis, recognition|defense response|signaling pattern recognition receptor activity|carbohydrate mediated signaling|integral component of membrane|low-density lipoprotein particle binding|endocytic vesicle membrane|toll-like receptor 3 signaling pathway|innate immune response|metal ion binding|regulation of immune response|protein homooligomerization|positive regulation of cell adhesion molecule production|extracellular exosome|cellular response to exogenous dsRNA hsa04145 Phagosome COLGALT1 7211.03655878618 6947.23499824862 7474.83811932374 1.07594433198361 0.10560343658527 0.434784884407446 1 74.433 78.966 86.363 84.4156 GeneID:79709,Genbank:NM_024656.3,HGNC:HGNC:26182,MIM:617531 collagen beta(1-O)galactosyltransferase 1 GO:0005788,GO:0016020,GO:0050211,GO:1904028 endoplasmic reticulum lumen|membrane|procollagen galactosyltransferase activity|positive regulation of collagen fibril organization hsa00310,hsa00514 Lysine degradation|Other types of O-glycan biosynthesis COLGALT2 1301.71851912228 1073.39093474955 1530.04610349501 1.42543229494669 0.511399515905562 0.000556892480360443 0.0663583556644534 4.35664 4.69826 6.81957 6.04905 GeneID:23127,Genbank:NM_001303420.1,HGNC:HGNC:16790,MIM:617533 collagen beta(1-O)galactosyltransferase 2 GO:0005788,GO:0050211 endoplasmic reticulum lumen|procollagen galactosyltransferase activity hsa00310,hsa00514 Lysine degradation|Other types of O-glycan biosynthesis COLQ 16.3112305791351 14.6923334036129 17.9301277546573 1.2203730518563 0.287322227947492 0.737355401665357 1 0.0719768 0.150155 0.123814 0.13666 GeneID:8292,Genbank:NM_080539.3,HGNC:HGNC:2226,MIM:603033 collagen like tail subunit of asymmetric acetylcholinesterase GO:0001507,GO:0005581,GO:0005605,GO:0005615,GO:0005886,GO:0008582,GO:0030054,GO:0031594,GO:0043083,GO:0071340,GO:0090150 acetylcholine catabolic process in synaptic cleft|collagen trimer|basal lamina|extracellular space|plasma membrane|regulation of synaptic growth at neuromuscular junction|cell junction|neuromuscular junction|synaptic cleft|skeletal muscle acetylcholine-gated channel clustering|establishment of protein localization to membrane COMMD1 331.776583570545 321.922782806173 341.630384334916 1.06121841193392 0.0857216113759405 0.658952642580768 1 2.88566 2.62242 2.48793 3.02456 GeneID:150684,Genbank:NM_001321781.1,HGNC:HGNC:23024,MIM:607238 copper metabolism domain containing 1 GO:0005507,GO:0005546,GO:0005547,GO:0005634,GO:0005654,GO:0005737,GO:0005769,GO:0005829,GO:0006351,GO:0006893,GO:0010008,GO:0015031,GO:0016567,GO:0031398,GO:0031462,GO:0032088,GO:0032434,GO:0042802,GO:0042803,GO:0043325,GO:0043687,GO:0048227,GO:0055037,GO:0055070,GO:0070062,GO:0070300,GO:0080025,GO:1902306,GO:2000009 copper ion binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|cytoplasm|early endosome|cytosol|transcription, DNA-templated|Golgi to plasma membrane transport|endosome membrane|protein transport|protein ubiquitination|positive regulation of protein ubiquitination|Cul2-RING ubiquitin ligase complex|negative regulation of NF-kappaB transcription factor activity|regulation of proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|protein homodimerization activity|phosphatidylinositol-3,4-bisphosphate binding|post-translational protein modification|plasma membrane to endosome transport|recycling endosome|copper ion homeostasis|extracellular exosome|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|negative regulation of sodium ion transmembrane transport|negative regulation of protein localization to cell surface COMMD10 359.140031167853 382.450488274607 335.829574061098 0.878099477859645 -0.187543706282571 0.322996640568581 1 1.82464 2.11109 1.60706 1.90769 GeneID:51397,Genbank:NM_016144.3,HGNC:HGNC:30201,MIM:616704 COMM domain containing 10 GO:0005634,GO:0005737,GO:0006351,GO:0006355 nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated COMMD2 485.43758853256 556.585464100322 414.289712964798 0.744341596549715 -0.425963233570903 0.0877903123322518 0.970228836454666 6.43336 6.28004 4.03414 5.44991 GeneID:51122,Genbank:NM_016094.3,HGNC:HGNC:24993,MIM:616699 COMM domain containing 2 GO:0005737,GO:0006351,GO:0006355 cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated COMMD3 99.4106220543107 103.355005536609 95.4662385720124 0.923673102007601 -0.114545738437975 0.723850930647382 1 22.3292 23.234 22.8792 25.005 GeneID:23412,Genbank:NM_012071.3,HGNC:HGNC:23332,MIM:616700 COMM domain containing 3 GO:0005576,GO:0005634,GO:0006351,GO:0006355,GO:0006814,GO:0043312,GO:1904813 extracellular region|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|sodium ion transport|neutrophil degranulation|ficolin-1-rich granule lumen COMMD4 2026.71865540845 1888.77907435548 2164.65823646142 1.14606216568769 0.196685302120021 0.270801929545445 1 47.9769 52.2778 57.9058 65.2844 GeneID:54939,Genbank:NM_017828.4,HGNC:HGNC:26027,MIM:616701 COMM domain containing 4 GO:0005634,GO:0005737,GO:0006351,GO:0006355 nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated COMMD5 661.030503187804 631.508553670006 690.552452705601 1.09349659429387 0.128948727104809 0.450645809926245 1 14.8006 16.5461 16.6194 18.403 GeneID:28991,Genbank:NM_001081003.2,HGNC:HGNC:17902,MIM:608216 COMM domain containing 5 GO:0005654,GO:0005829,GO:0006351,GO:0006355 nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated COMMD6 669.037483067887 643.635877205101 694.439088930673 1.07893160329436 0.10960341096528 0.611804868754954 1 3.08867 2.92 3.10164 3.31683 GeneID:170622,Genbank:NM_203497.3,HGNC:HGNC:24015,MIM:612377 COMM domain containing 6 GO:0005634,GO:0005737,GO:0006351,GO:0032088,GO:0051059 nucleus|cytoplasm|transcription, DNA-templated|negative regulation of NF-kappaB transcription factor activity|NF-kappaB binding COMMD7 1444.37612289941 1408.81520274732 1479.93704305151 1.05048344180663 0.0710534217808534 0.681942506712796 1 20.5346 23.1356 21.9011 24.534 GeneID:149951,Genbank:NM_001099339.1,HGNC:HGNC:16223,MIM:616703 COMM domain containing 7 GO:0006351,GO:0031410,GO:0032088,GO:0033209,GO:0043231,GO:0045892,GO:0051059,GO:0070062 transcription, DNA-templated|cytoplasmic vesicle|negative regulation of NF-kappaB transcription factor activity|tumor necrosis factor-mediated signaling pathway|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated|NF-kappaB binding|extracellular exosome COMMD8 261.010572162546 271.474854369889 250.546289955203 0.922907908125552 -0.115741398391241 0.6059739318291 1 4.41627 4.18621 3.76778 3.92704 GeneID:54951,Genbank:NM_001329668.1,HGNC:HGNC:26036,MIM:616656 COMM domain containing 8 GO:0005654,GO:0005829,GO:0006351,GO:0006355 nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated COMMD9 1176.7739481593 1148.82167902969 1204.7262172889 1.04866250287549 0.0685504417176233 0.651911443700153 1 12.6721 13.0875 13.3333 14.1886 GeneID:29099,Genbank:NM_001101653.1,HGNC:HGNC:25014,MIM:612299 COMM domain containing 9 GO:0005576,GO:0005634,GO:0005794,GO:0005829,GO:0006351,GO:0006355,GO:0006814,GO:0034774,GO:0042632,GO:0043312,GO:1904813 extracellular region|nucleus|Golgi apparatus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|sodium ion transport|secretory granule lumen|cholesterol homeostasis|neutrophil degranulation|ficolin-1-rich granule lumen COMP 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:1311,Genbank:NM_000095.2,HGNC:HGNC:2227,MIM:600310 cartilage oligomeric matrix protein GO:0001501,GO:0002020,GO:0003417,GO:0005201,GO:0005509,GO:0005518,GO:0005576,GO:0005578,GO:0005615,GO:0006915,GO:0007155,GO:0008201,GO:0009887,GO:0030198,GO:0043066,GO:0043395,GO:0060173,GO:0070062 skeletal system development|protease binding|growth plate cartilage development|extracellular matrix structural constituent|calcium ion binding|collagen binding|extracellular region|proteinaceous extracellular matrix|extracellular space|apoptotic process|cell adhesion|heparin binding|animal organ morphogenesis|extracellular matrix organization|negative regulation of apoptotic process|heparan sulfate proteoglycan binding|limb development|extracellular exosome hsa04145,hsa04151,hsa04510,hsa04512,hsa05144,hsa05165 Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection COMT 2098.26842179446 2084.16941690899 2112.36742667994 1.0135296149834 0.0193882444688132 0.907538353197578 1 16.8202 18.0134 16.7437 19.0983 GeneID:1312,Genbank:NM_000754.3,HGNC:HGNC:2228,MIM:116790 catechol-O-methyltransferase hsa00140,hsa00350,hsa04728 Steroid hormone biosynthesis|Tyrosine metabolism|Dopaminergic synapse COMTD1 227.084468248948 222.056112013059 232.112824484837 1.04528905951117 0.0639019538438655 0.79169557519163 1 6.57155 6.38146 6.67204 8.34457 GeneID:118881,Genbank:NM_144589.3,HGNC:HGNC:26309 catechol-O-methyltransferase domain containing 1 GO:0005739,GO:0008171,GO:0016021 mitochondrion|O-methyltransferase activity|integral component of membrane COP1 692.707463459322 693.851448921359 691.563477997285 0.996702506094597 -0.00476513893792215 0.9797184696502 1 2.36607 2.53154 2.47573 2.26922 GeneID:64326,Genbank:NM_001286644.1,HGNC:HGNC:17440,MIM:608067 COP1, E3 ubiquitin ligase GO:0000139,GO:0004842,GO:0005654,GO:0005829,GO:0010212,GO:0016607,GO:0031464,GO:0032436,GO:0043161,GO:0043687,GO:0046872,GO:0061630 Golgi membrane|ubiquitin-protein transferase activity|nucleoplasm|cytosol|response to ionizing radiation|nuclear speck|Cul4A-RING E3 ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|metal ion binding|ubiquitin protein ligase activity hsa04115,hsa04120 p53 signaling pathway|Ubiquitin mediated proteolysis COPA 5711.60487791864 5703.0266072766 5720.18314856069 1.0030083221534 0.00433357631861607 0.968408911339693 1 32.1983 31.9468 34.1275 30.8782 GeneID:1314,Genbank:NM_004371.3,HGNC:HGNC:2230,MIM:601924 coatomer protein complex subunit alpha COPB1 1458.21105594056 1515.73091026315 1400.69120161796 0.924102815436267 -0.113874720445086 0.590740807227602 1 15.48 13.1897 15.064 11.915 GeneID:1315,Genbank:NM_001144061.1,HGNC:HGNC:2231,MIM:600959 coatomer protein complex subunit beta 1 GO:0000139,GO:0005198,GO:0005789,GO:0005793,GO:0005794,GO:0005798,GO:0005829,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0016020,GO:0016032,GO:0030126,GO:0030133,GO:0030667,GO:0043231,GO:0043312,GO:0070821,GO:0101003 Golgi membrane|structural molecule activity|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|Golgi-associated vesicle|cytosol|plasma membrane|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|membrane|viral process|COPI vesicle coat|transport vesicle|secretory granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|tertiary granule membrane|ficolin-1-rich granule membrane COPB2 3827.0136606032 3818.98251680472 3835.04480440169 1.00420590760138 0.00605511731433927 0.931415215550192 1 25.8104 22.5344 26.8862 22.6749 GeneID:9276,Genbank:XM_024453831.1,HGNC:HGNC:2232,MIM:606990 coatomer protein complex subunit beta 2 GO:0000139,GO:0005198,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0030126,GO:0030133,GO:1901998 Golgi membrane|structural molecule activity|endoplasmic reticulum membrane|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|COPI vesicle coat|transport vesicle|toxin transport COPE 5218.64930454109 4670.55884926892 5766.73975981326 1.23470016028509 0.304160734287728 0.0403607227741304 0.758464027333929 115.735 120.962 140.464 155.313 GeneID:11316,Genbank:NM_001330469.1,HGNC:HGNC:2234,MIM:606942 coatomer protein complex subunit epsilon GO:0000139,GO:0005198,GO:0005654,GO:0005789,GO:0005794,GO:0005829,GO:0006888,GO:0006890,GO:0006891,GO:0015031,GO:0030126,GO:0030133 Golgi membrane|structural molecule activity|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|protein transport|COPI vesicle coat|transport vesicle COPG1 4907.52668444494 4602.04287154255 5213.01049734732 1.1327600899989 0.179842341636153 0.180258099853436 1 47.0575 47.9473 54.7183 55.4526 GeneID:22820,Genbank:XM_011512549.2,HGNC:HGNC:2236,MIM:615525 coatomer protein complex subunit gamma 1 GO:0000139,GO:0005198,GO:0005789,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0030126,GO:0030133,GO:0051683,GO:0072384 Golgi membrane|structural molecule activity|endoplasmic reticulum membrane|Golgi apparatus|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|COPI vesicle coat|transport vesicle|establishment of Golgi localization|organelle transport along microtubule COPG2 1355.73098498361 1313.31790594968 1398.14406401755 1.06458920394185 0.0902968409998129 0.525157798215002 1 12.1156 11.1751 13.0067 12.3802 GeneID:26958,Genbank:NM_012133.5,HGNC:HGNC:2237,MIM:604355 coatomer protein complex subunit gamma 2 GO:0000139,GO:0005198,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0030126,GO:0030133 Golgi membrane|structural molecule activity|endoplasmic reticulum membrane|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|COPI vesicle coat|transport vesicle COPRS 1622.10970495918 1509.83552113372 1734.38388878464 1.14872372818617 0.200031866825347 0.171487525038824 1 41.2469 42.6624 46.4964 50.7203 GeneID:55352,Genbank:NM_018405.3,HGNC:HGNC:28848 coordinator of PRMT5 and differentiation stimulator GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006351,GO:0006355,GO:0007517,GO:0042393,GO:0043985 nucleus|nucleoplasm|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|muscle organ development|histone binding|histone H4-R3 methylation COPS2 833.668448067741 878.257289877108 789.079606258375 0.8984606394429 -0.154472792626121 0.546814501564574 1 8.76453 7.56234 8.88852 6.0479 GeneID:9318,Genbank:NM_004236.3,HGNC:HGNC:30747,MIM:604508 COP9 signalosome subunit 2 GO:0000122,GO:0000338,GO:0003714,GO:0005634,GO:0005737,GO:0008180,GO:0008283,GO:0030182,GO:0035914,GO:0045892,GO:1903507 negative regulation of transcription from RNA polymerase II promoter|protein deneddylation|transcription corepressor activity|nucleus|cytoplasm|COP9 signalosome|cell proliferation|neuron differentiation|skeletal muscle cell differentiation|negative regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription COPS3 2698.2572693812 2808.64135612171 2587.8731826407 0.921396808816539 -0.118105493594388 0.400418698160249 1 41.631 39.0245 38.836 37.6147 GeneID:8533,Genbank:NM_001316358.1,HGNC:HGNC:2239,MIM:604665 COP9 signalosome subunit 3 GO:0000338,GO:0000715,GO:0001701,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006283,GO:0006511,GO:0007165,GO:0008180,GO:0009416,GO:0043687 protein deneddylation|nucleotide-excision repair, DNA damage recognition|in utero embryonic development|nucleus|nucleoplasm|cytoplasm|cytosol|transcription-coupled nucleotide-excision repair|ubiquitin-dependent protein catabolic process|signal transduction|COP9 signalosome|response to light stimulus|post-translational protein modification COPS4 649.909095268393 664.937236205875 634.880954330912 0.954798317437502 -0.0667320708081743 0.700487270852269 1 11.4672 11.5934 11.8941 10.2736 GeneID:51138,Genbank:NM_001330727.1,HGNC:HGNC:16702,MIM:616008 COP9 signalosome subunit 4 GO:0000338,GO:0000715,GO:0005634,GO:0005654,GO:0005829,GO:0006283,GO:0008021,GO:0008180,GO:0016607,GO:0019784,GO:0030054,GO:0043687,GO:0070062 protein deneddylation|nucleotide-excision repair, DNA damage recognition|nucleus|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|synaptic vesicle|COP9 signalosome|nuclear speck|NEDD8-specific protease activity|cell junction|post-translational protein modification|extracellular exosome COPS5 1067.37570563806 1119.95447558804 1014.79693568808 0.906105522865341 -0.142249022044562 0.362493691737012 1 30.2484 26.4545 26.237 25.893 GeneID:10987,Genbank:NM_006837.2,HGNC:HGNC:2240,MIM:604850 COP9 signalosome subunit 5 GO:0000338,GO:0000715,GO:0003713,GO:0003743,GO:0004843,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005852,GO:0006283,GO:0006366,GO:0006412,GO:0008021,GO:0008180,GO:0008237,GO:0016579,GO:0019784,GO:0019899,GO:0030054,GO:0035718,GO:0043066,GO:0043687,GO:0045944,GO:0046328,GO:0046872,GO:0048471,GO:0051091,GO:0051726,GO:1903894,GO:1990182 protein deneddylation|nucleotide-excision repair, DNA damage recognition|transcription coactivator activity|translation initiation factor activity|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|cytoplasm|cytosol|eukaryotic translation initiation factor 3 complex|transcription-coupled nucleotide-excision repair|transcription from RNA polymerase II promoter|translation|synaptic vesicle|COP9 signalosome|metallopeptidase activity|protein deubiquitination|NEDD8-specific protease activity|enzyme binding|cell junction|macrophage migration inhibitory factor binding|negative regulation of apoptotic process|post-translational protein modification|positive regulation of transcription from RNA polymerase II promoter|regulation of JNK cascade|metal ion binding|perinuclear region of cytoplasm|positive regulation of DNA binding transcription factor activity|regulation of cell cycle|regulation of IRE1-mediated unfolded protein response|exosomal secretion COPS6 5186.7977860043 5374.41058898071 4999.18498302788 0.930182928948122 -0.104413631640489 0.423129605103516 1 140.322 146.258 131.338 138.294 GeneID:10980,Genbank:NM_006833.4,HGNC:HGNC:21749,MIM:614729 COP9 signalosome subunit 6 GO:0000338,GO:0000715,GO:0005654,GO:0005829,GO:0006283,GO:0008180,GO:0016032,GO:0043687,GO:0070062 protein deneddylation|nucleotide-excision repair, DNA damage recognition|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|COP9 signalosome|viral process|post-translational protein modification|extracellular exosome COPS7A 1376.1019933797 1449.6636168983 1302.5403698611 0.898512147699485 -0.154390086079987 0.432490248789946 1 27.1253 29.108 22.8107 27.4905 GeneID:50813,Genbank:NM_001164095.2,HGNC:HGNC:16758,MIM:616009 COP9 signalosome subunit 7A GO:0000338,GO:0000715,GO:0005654,GO:0005829,GO:0006283,GO:0008180,GO:0043687 protein deneddylation|nucleotide-excision repair, DNA damage recognition|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|COP9 signalosome|post-translational protein modification COPS7B 891.606290120307 894.892325580044 888.32025466057 0.992656020471274 -0.0106342195637301 0.94753940280773 1 5.539 5.98228 5.86055 5.49124 GeneID:64708,Genbank:NM_001282951.2,HGNC:HGNC:16760,MIM:616010 COP9 signalosome subunit 7B GO:0000338,GO:0000715,GO:0005654,GO:0005829,GO:0006283,GO:0008180,GO:0043687 protein deneddylation|nucleotide-excision repair, DNA damage recognition|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|COP9 signalosome|post-translational protein modification COPS8 1628.20494964136 1620.32784128903 1636.0820579937 1.00972285750033 0.0139593652774639 0.914810153327495 1 30.3587 27.9644 30.9189 29.6741 GeneID:10920,Genbank:NM_198189.2,HGNC:HGNC:24335,MIM:616011 COP9 signalosome subunit 8 GO:0000338,GO:0000715,GO:0005634,GO:0005654,GO:0005829,GO:0006283,GO:0007250,GO:0008180,GO:0008285,GO:0010387,GO:0043687,GO:0048471,GO:0070062 protein deneddylation|nucleotide-excision repair, DNA damage recognition|nucleus|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|activation of NF-kappaB-inducing kinase activity|COP9 signalosome|negative regulation of cell proliferation|COP9 signalosome assembly|post-translational protein modification|perinuclear region of cytoplasm|extracellular exosome COPS9 573.75193919364 600.481184868384 547.022693518896 0.910973911095641 -0.134518356855523 0.720055515243465 1 10.1808 12.1292 7.68611 12.8858 GeneID:150678,Genbank:XM_017003411.1,HGNC:HGNC:21314 COP9 signalosome subunit 9 GO:0000790,GO:0005634,GO:0005654,GO:0005737,GO:0008180,GO:0008284,GO:0034644 nuclear chromatin|nucleus|nucleoplasm|cytoplasm|COP9 signalosome|positive regulation of cell proliferation|cellular response to UV COPZ1 3184.80910134575 3092.73563943036 3276.88256326115 1.05954176020835 0.0834404504360889 0.541384185281745 1 59.5463 62.0451 62.7139 67.6186 GeneID:22818,Genbank:NM_001271736.1,HGNC:HGNC:2243,MIM:615472 coatomer protein complex subunit zeta 1 GO:0000139,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0030126,GO:0030133,GO:1901998 Golgi membrane|endoplasmic reticulum membrane|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|COPI vesicle coat|transport vesicle|toxin transport COPZ2 19.9066321583972 12.1939501191412 27.6193141976532 2.26500140871484 1.17951194755419 0.0708492821382068 0.924040800265082 0.300546 0.540417 0.803707 0.832125 GeneID:51226,Genbank:NM_016429.3,HGNC:HGNC:19356,MIM:615526 coatomer protein complex subunit zeta 2 GO:0000139,GO:0005789,GO:0005801,GO:0005829,GO:0006886,GO:0006888,GO:0006890,GO:0030126,GO:0030133,GO:0033116 Golgi membrane|endoplasmic reticulum membrane|cis-Golgi network|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|COPI vesicle coat|transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane COQ10A 258.288235436646 284.908695976585 231.667774896706 0.813129883953228 -0.29844227768083 0.156091060810196 1 8.01223 7.7988 7.35081 5.73164 GeneID:93058,Genbank:NM_144576.3,HGNC:HGNC:26515 coenzyme Q10A GO:0005739,GO:0005743,GO:0006744,GO:0045333,GO:0048039 mitochondrion|mitochondrial inner membrane|ubiquinone biosynthetic process|cellular respiration|ubiquinone binding COQ10B 637.911070556875 675.353197160818 600.468943952931 0.889118384983295 -0.169552570031027 0.317860560346312 1 12.0405 11.3039 10.8272 9.74806 GeneID:80219,Genbank:NM_025147.4,HGNC:HGNC:25819 coenzyme Q10B GO:0005739,GO:0005743,GO:0006744,GO:0045333,GO:0048039 mitochondrion|mitochondrial inner membrane|ubiquinone biosynthetic process|cellular respiration|ubiquinone binding COQ2 834.849092563763 830.80965878407 838.888526343455 1.00972408959618 0.0139611256986258 0.939621663682121 1 4.166 4.41599 4.51185 4.38567 GeneID:27235,Genbank:XM_017008032.2,HGNC:HGNC:25223,MIM:609825 coenzyme Q2, polyprenyltransferase GO:0002083,GO:0005743,GO:0006071,GO:0006744,GO:0008299,GO:0031305,GO:0047293 4-hydroxybenzoate decaprenyltransferase activity|mitochondrial inner membrane|glycerol metabolic process|ubiquinone biosynthetic process|isoprenoid biosynthetic process|integral component of mitochondrial inner membrane|4-hydroxybenzoate nonaprenyltransferase activity hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ3 357.036899359825 359.830768545414 354.243030174236 0.984471204633873 -0.0225790863628317 0.908951747184316 1 5.5821 5.93525 5.15916 5.59354 GeneID:51805,Genbank:XM_006715500.3,HGNC:HGNC:18175,MIM:605196 coenzyme Q3, methyltransferase GO:0004395,GO:0005739,GO:0005743,GO:0005759,GO:0006071,GO:0006744,GO:0008171,GO:0008425,GO:0008689,GO:0010795,GO:0044595,GO:0044596 hexaprenyldihydroxybenzoate methyltransferase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|glycerol metabolic process|ubiquinone biosynthetic process|O-methyltransferase activity|2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|regulation of ubiquinone biosynthetic process|decaprenyldihydroxybenzoate methyltransferase activity|3-demethylubiquinone-10 3-O-methyltransferase activity hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ4 404.811863522372 380.279497258677 429.344229786068 1.12902281842983 0.175074644395128 0.441836416091792 1 6.18793 8.31444 7.31588 9.42042 GeneID:51117,Genbank:XM_017014792.1,HGNC:HGNC:19693,MIM:612898 coenzyme Q4 GO:0005739,GO:0005743,GO:0006744,GO:0043234 mitochondrion|mitochondrial inner membrane|ubiquinone biosynthetic process|protein complex COQ5 531.745417563598 532.86215705423 530.628678072966 0.995808523927443 -0.00605973024136526 0.953444239405604 1 8.77732 10.963 9.42975 10.3618 GeneID:84274,Genbank:XM_024449224.1,HGNC:HGNC:28722,MIM:616359 coenzyme Q5, methyltransferase GO:0005743,GO:0005759,GO:0006744,GO:0032259,GO:0043234,GO:0102005 mitochondrial inner membrane|mitochondrial matrix|ubiquinone biosynthetic process|methylation|protein complex|2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ6 368.035092449247 340.103450953281 395.966733945213 1.1642537964121 0.219405586522406 0.250780612980963 1 2.87502 3.24818 3.84722 3.51501 GeneID:51004,Genbank:NM_182480.2,HGNC:HGNC:20233,MIM:614647 coenzyme Q6, monooxygenase GO:0005739,GO:0005743,GO:0005794,GO:0006744,GO:0016709,GO:0042995,GO:0071949 mitochondrion|mitochondrial inner membrane|Golgi apparatus|ubiquinone biosynthetic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|cell projection|FAD binding hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ7 590.662546779302 586.201470626719 595.123622931885 1.01522028304642 0.0217927981275176 0.915640435970018 1 5.44775 6.18379 6.17874 5.55572 GeneID:10229,Genbank:NM_016138.4,HGNC:HGNC:2244,MIM:601683 coenzyme Q7, hydroxylase GO:0000122,GO:0003682,GO:0004497,GO:0005634,GO:0005739,GO:0005743,GO:0006744,GO:0045944,GO:0046872,GO:2000377 negative regulation of transcription from RNA polymerase II promoter|chromatin binding|monooxygenase activity|nucleus|mitochondrion|mitochondrial inner membrane|ubiquinone biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|regulation of reactive oxygen species metabolic process hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis COQ8A 443.533852289474 468.846116842303 418.221587736646 0.892023145149169 -0.164846950931555 0.346435442503176 1 5.36124 5.81551 5.00459 5.21437 GeneID:56997,Genbank:XM_017001852.1,HGNC:HGNC:16812,MIM:606980 coenzyme Q8A GO:0005524,GO:0005739,GO:0006744,GO:0016021,GO:0016301,GO:0016310,GO:0043531 ATP binding|mitochondrion|ubiquinone biosynthetic process|integral component of membrane|kinase activity|phosphorylation|ADP binding COQ8B 486.457325923941 452.953126571566 519.961525276316 1.14793671745229 0.199043112454198 0.413115658463141 1 5.7044 7.15989 7.08137 8.71641 GeneID:79934,Genbank:NM_024876.3,HGNC:HGNC:19041,MIM:615567 coenzyme Q8B GO:0005524,GO:0005739,GO:0005829,GO:0005886,GO:0006744,GO:0016021,GO:0016301,GO:0021692,GO:0031966 ATP binding|mitochondrion|cytosol|plasma membrane|ubiquinone biosynthetic process|integral component of membrane|kinase activity|cerebellar Purkinje cell layer morphogenesis|mitochondrial membrane COQ9 1912.3548500669 1731.70933670315 2093.00036343064 1.20863260309915 0.273375764653991 0.056719620919834 0.865163284430535 36.1039 40.4909 45.9161 48.3423 GeneID:57017,Genbank:NM_020312.3,HGNC:HGNC:25302,MIM:612837 coenzyme Q9 GO:0005739,GO:0005743,GO:0006120,GO:0006744,GO:0008289,GO:0042803 mitochondrion|mitochondrial inner membrane|mitochondrial electron transport, NADH to ubiquinone|ubiquinone biosynthetic process|lipid binding|protein homodimerization activity CORIN 2.94856227892267 2.98845468642911 2.90866987141623 0.973302317289534 -0.0390401049777162 1 1 0.00838144 0.0392696 0.0240542 0.0148804 GeneID:10699,Genbank:NM_001278585.1,HGNC:HGNC:19012,MIM:605236 corin, serine peptidase GO:0003050,GO:0004252,GO:0005576,GO:0005886,GO:0005887,GO:0007565,GO:0008217,GO:0009986,GO:0015629,GO:0016021,GO:0016486,GO:0016604,GO:0035813,GO:1903779 regulation of systemic arterial blood pressure by atrial natriuretic peptide|serine-type endopeptidase activity|extracellular region|plasma membrane|integral component of plasma membrane|female pregnancy|regulation of blood pressure|cell surface|actin cytoskeleton|integral component of membrane|peptide hormone processing|nuclear body|regulation of renal sodium excretion|regulation of cardiac conduction CORO1A 67.4686896013751 63.6984565984944 71.2389226042558 1.11837753076642 0.161407281046392 0.658424532758298 1 1.06354 1.00952 1.134 1.15686 GeneID:11151,Genbank:NM_001193333.2,HGNC:HGNC:2252,MIM:605000 coronin 1A GO:0001772,GO:0001845,GO:0001891,GO:0003723,GO:0003779,GO:0003785,GO:0005737,GO:0005769,GO:0005829,GO:0005884,GO:0005886,GO:0005911,GO:0006816,GO:0006909,GO:0006928,GO:0007015,GO:0008022,GO:0008092,GO:0008360,GO:0016020,GO:0030027,GO:0030036,GO:0030335,GO:0030424,GO:0030595,GO:0030670,GO:0030864,GO:0031339,GO:0031589,GO:0032036,GO:0032796,GO:0032956,GO:0038180,GO:0042102,GO:0042803,GO:0043029,GO:0043234,GO:0043320,GO:0043524,GO:0043548,GO:0045087,GO:0045335,GO:0048873,GO:0050918,GO:0051015,GO:0051126,GO:0051279,GO:0061502,GO:0070062,GO:0071353 immunological synapse|phagolysosome assembly|phagocytic cup|RNA binding|actin binding|actin monomer binding|cytoplasm|early endosome|cytosol|actin filament|plasma membrane|cell-cell junction|calcium ion transport|phagocytosis|movement of cell or subcellular component|actin filament organization|protein C-terminus binding|cytoskeletal protein binding|regulation of cell shape|membrane|lamellipodium|actin cytoskeleton organization|positive regulation of cell migration|axon|leukocyte chemotaxis|phagocytic vesicle membrane|cortical actin cytoskeleton|negative regulation of vesicle fusion|cell-substrate adhesion|myosin heavy chain binding|uropod organization|regulation of actin cytoskeleton organization|nerve growth factor signaling pathway|positive regulation of T cell proliferation|protein homodimerization activity|T cell homeostasis|protein complex|natural killer cell degranulation|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|innate immune response|phagocytic vesicle|homeostasis of number of cells within a tissue|positive chemotaxis|actin filament binding|negative regulation of actin nucleation|regulation of release of sequestered calcium ion into cytosol|early endosome to recycling endosome transport|extracellular exosome|cellular response to interleukin-4 hsa04145,hsa05152 Phagosome|Tuberculosis CORO1B 2192.3476757265 2135.19366064149 2249.50169081151 1.05353520492173 0.0752385240435758 0.605159769604526 1 42.7856 43.8671 44.4436 49.0526 GeneID:57175,Genbank:NM_001018070.2,HGNC:HGNC:2253,MIM:609849 coronin 1B GO:0001725,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005925,GO:0016477,GO:0030027,GO:0030036,GO:0031252,GO:0031529,GO:0034315,GO:0034316,GO:0035767,GO:0036120,GO:0042060,GO:0042802,GO:0045296,GO:0048471,GO:0051015,GO:0051017,GO:0070062,GO:0071672,GO:0071933,GO:0071944,GO:0090135,GO:1902463,GO:2000394 stress fiber|cytoplasm|cytosol|actin filament|plasma membrane|focal adhesion|cell migration|lamellipodium|actin cytoskeleton organization|cell leading edge|ruffle organization|regulation of Arp2/3 complex-mediated actin nucleation|negative regulation of Arp2/3 complex-mediated actin nucleation|endothelial cell chemotaxis|cellular response to platelet-derived growth factor stimulus|wound healing|identical protein binding|cadherin binding|perinuclear region of cytoplasm|actin filament binding|actin filament bundle assembly|extracellular exosome|negative regulation of smooth muscle cell chemotaxis|Arp2/3 complex binding|cell periphery|actin filament branching|protein localization to cell leading edge|positive regulation of lamellipodium morphogenesis CORO1C 7447.34900760033 7617.46762297407 7277.2303922266 0.955334601000295 -0.0659219767572184 0.624376115743633 1 49.9533 47.5619 48.906 45.7346 GeneID:23603,Genbank:XM_024448916.1,HGNC:HGNC:2254,MIM:605269 coronin 1C GO:0001755,GO:0001932,GO:0001933,GO:0005737,GO:0005925,GO:0006909,GO:0007165,GO:0010632,GO:0010633,GO:0010762,GO:0015629,GO:0016328,GO:0016600,GO:0030027,GO:0030036,GO:0044387,GO:0045184,GO:0048365,GO:0051015,GO:0051893,GO:0051895,GO:0090630,GO:1900024,GO:1900025,GO:1900027,GO:2000394 neural crest cell migration|regulation of protein phosphorylation|negative regulation of protein phosphorylation|cytoplasm|focal adhesion|phagocytosis|signal transduction|regulation of epithelial cell migration|negative regulation of epithelial cell migration|regulation of fibroblast migration|actin cytoskeleton|lateral plasma membrane|flotillin complex|lamellipodium|actin cytoskeleton organization|negative regulation of protein kinase activity by regulation of protein phosphorylation|establishment of protein localization|Rac GTPase binding|actin filament binding|regulation of focal adhesion assembly|negative regulation of focal adhesion assembly|activation of GTPase activity|regulation of substrate adhesion-dependent cell spreading|negative regulation of substrate adhesion-dependent cell spreading|regulation of ruffle assembly|positive regulation of lamellipodium morphogenesis CORO2A 275.630397281183 294.450375332092 256.810419230273 0.872168761682279 -0.197320776301295 0.477244307061168 1 1.65668 1.48009 1.12998 1.63551 GeneID:7464,Genbank:NM_052820.3,HGNC:HGNC:2255,MIM:602159 coronin 2A GO:0015629,GO:0017053,GO:0030036,GO:0035556,GO:0051015 actin cytoskeleton|transcriptional repressor complex|actin cytoskeleton organization|intracellular signal transduction|actin filament binding CORO2B 309.275613386534 258.436048616635 360.115178156433 1.39344019568504 0.478651085513071 0.016566453628739 0.534873364697483 2.13975 2.25777 3.60288 2.71875 GeneID:10391,Genbank:NM_001324014.1,HGNC:HGNC:2256,MIM:605002 coronin 2B GO:0003779,GO:0005737,GO:0015629,GO:0016020,GO:0030036,GO:0051015 actin binding|cytoplasm|actin cytoskeleton|membrane|actin cytoskeleton organization|actin filament binding CORO6 16.6088606681423 16.2586001588549 16.9591211774296 1.04308618280358 0.0608583624278719 0.995564058088252 1 0.120587 0.185967 0.144565 0.155831 GeneID:84940,Genbank:XM_017025235.2,HGNC:HGNC:21356 coronin 6 GO:0015629,GO:0030036,GO:0051015 actin cytoskeleton|actin cytoskeleton organization|actin filament binding CORO7 49.7698578006175 53.0227469599102 46.5169686413247 0.877302126132686 -0.188854329969851 0.669147132509491 1 3.906 3.36074 3.24165 3.24906 GeneID:79585,Genbank:NM_001201473.1,HGNC:HGNC:26161,MIM:611668 coronin 7 GO:0000139,GO:0003779,GO:0005794,GO:0005802,GO:0005829,GO:0006895,GO:0015031,GO:0016020,GO:0016021,GO:0030041,GO:0031410 Golgi membrane|actin binding|Golgi apparatus|trans-Golgi network|cytosol|Golgi to endosome transport|protein transport|membrane|integral component of membrane|actin filament polymerization|cytoplasmic vesicle CORT 0.969266633120943 0 1.93853326624189 Inf Inf 0.451830900262006 1 5.1855e-08 1.62245e-08 0.256162 0.0813848 GeneID:1325,Genbank:NM_001302.4,HGNC:HGNC:2257,MIM:602784 cortistatin GO:0001664,GO:0005184,GO:0005576,GO:0005615,GO:0007186,GO:0007193,GO:0007268 G-protein coupled receptor binding|neuropeptide hormone activity|extracellular region|extracellular space|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|chemical synaptic transmission hsa04080 Neuroactive ligand-receptor interaction COTL1 8154.26534340341 8526.91837314222 7781.6123136646 0.912593738222573 -0.131955340146349 0.30199863750564 1 212.774 222.342 204.769 200.221 GeneID:23406,Genbank:NM_021149.3,HGNC:HGNC:18304,MIM:606748 coactosin like F-actin binding protein 1 GO:0003779,GO:0005576,GO:0005634,GO:0005856,GO:0019899,GO:0034774,GO:0043312,GO:0050832,GO:0070062,GO:1904813 actin binding|extracellular region|nucleus|cytoskeleton|enzyme binding|secretory granule lumen|neutrophil degranulation|defense response to fungus|extracellular exosome|ficolin-1-rich granule lumen COX10 426.003287494456 403.234383909809 448.772191079103 1.11293135949309 0.154364616603833 0.385261585892428 1 6.33783 5.51259 7.04698 6.47962 GeneID:1352,Genbank:NM_001303.3,HGNC:HGNC:2260,MIM:602125 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor GO:0000266,GO:0004311,GO:0005730,GO:0005739,GO:0005743,GO:0005829,GO:0006123,GO:0006783,GO:0006784,GO:0008495,GO:0008535,GO:0016021,GO:0045333,GO:0048034,GO:0070069,GO:1902600 mitochondrial fission|farnesyltranstransferase activity|nucleolus|mitochondrion|mitochondrial inner membrane|cytosol|mitochondrial electron transport, cytochrome c to oxygen|heme biosynthetic process|heme a biosynthetic process|protoheme IX farnesyltransferase activity|respiratory chain complex IV assembly|integral component of membrane|cellular respiration|heme O biosynthetic process|cytochrome complex|hydrogen ion transmembrane transport hsa00190,hsa00860,hsa04714 Oxidative phosphorylation|Porphyrin and chlorophyll metabolism|Thermogenesis COX11 1040.62322658394 1084.34397638028 996.902476787611 0.919359998766664 -0.121298198839686 0.433006959201661 1 8.46585 8.23411 8.14808 7.52315 GeneID:1353,Genbank:XM_017024196.2,HGNC:HGNC:2261,MIM:603648 COX11, cytochrome c oxidase copper chaperone GO:0004129,GO:0005507,GO:0005739,GO:0005743,GO:0007585,GO:0008535,GO:0009055,GO:0016021,GO:0033132,GO:0043234,GO:0055065 cytochrome-c oxidase activity|copper ion binding|mitochondrion|mitochondrial inner membrane|respiratory gaseous exchange|respiratory chain complex IV assembly|electron transfer activity|integral component of membrane|negative regulation of glucokinase activity|protein complex|metal ion homeostasis hsa00190,hsa04714 Oxidative phosphorylation|Thermogenesis COX14 454.766084328716 487.987310483109 421.544858174324 0.863843893311474 -0.211157470801388 0.502907592947937 1 20.5602 20.2817 14.9357 21.5489 GeneID:84987,Genbank:NM_001257134.1,HGNC:HGNC:28216,MIM:614478 COX14, cytochrome c oxidase assembly factor GO:0005739,GO:0016021,GO:0031966,GO:0033617 mitochondrion|integral component of membrane|mitochondrial membrane|mitochondrial respiratory chain complex IV assembly hsa04714 Thermogenesis COX15 1137.00688216526 1045.9077016195 1228.10606271101 1.17420118506575 0.23167961784315 0.118912011244127 1 5.98108 5.81972 7.56126 6.45013 GeneID:1355,Genbank:NM_001320974.1,HGNC:HGNC:2263,MIM:603646 COX15, cytochrome c oxidase assembly homolog GO:0004129,GO:0005634,GO:0005739,GO:0005743,GO:0005746,GO:0006123,GO:0006783,GO:0006784,GO:0007585,GO:0008535,GO:0016021,GO:0016627,GO:0045333,GO:0055114,GO:0070069,GO:1902600 cytochrome-c oxidase activity|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain|mitochondrial electron transport, cytochrome c to oxygen|heme biosynthetic process|heme a biosynthetic process|respiratory gaseous exchange|respiratory chain complex IV assembly|integral component of membrane|oxidoreductase activity, acting on the CH-CH group of donors|cellular respiration|oxidation-reduction process|cytochrome complex|hydrogen ion transmembrane transport hsa00190,hsa00860,hsa04714 Oxidative phosphorylation|Porphyrin and chlorophyll metabolism|Thermogenesis COX16 19.9512998175384 16.6428103563344 23.2597892787424 1.39758783406971 0.482938954835767 0.445359196696913 1 13.7334 13.2089 12.2075 11.6079 GeneID:51241,Genbank:NM_001204090.1,HGNC:HGNC:20213 COX16, cytochrome c oxidase assembly homolog GO:0016021,GO:0031966 integral component of membrane|mitochondrial membrane hsa04714 Thermogenesis COX17 982.777364455627 995.912643966452 969.642084944802 0.973621623160621 -0.0385668856687313 0.828491997115907 1 116.807 115.814 103.326 117.864 GeneID:10063,Genbank:NM_005694.1,HGNC:HGNC:2264,MIM:604813 COX17, cytochrome c oxidase copper chaperone GO:0005507,GO:0005737,GO:0005758,GO:0006091,GO:0006825,GO:0007420,GO:0007507,GO:0008284,GO:0016531,GO:0033617,GO:1903136,GO:1904960 copper ion binding|cytoplasm|mitochondrial intermembrane space|generation of precursor metabolites and energy|copper ion transport|brain development|heart development|positive regulation of cell proliferation|copper chaperone activity|mitochondrial respiratory chain complex IV assembly|cuprous ion binding|positive regulation of cytochrome-c oxidase activity hsa00190,hsa04714 Oxidative phosphorylation|Thermogenesis COX18 572.85135714244 598.059236823066 547.643477461813 0.915701060602182 -0.127051401343072 0.440627648372594 1 5.1705 5.89128 5.12142 4.69999 GeneID:285521,Genbank:NM_001300729.1,HGNC:HGNC:26801,MIM:610428 COX18, cytochrome c oxidase assembly factor GO:0008535,GO:0008565,GO:0031305,GO:0032977,GO:0032979,GO:0033617,GO:0051204 respiratory chain complex IV assembly|protein transporter activity|integral component of mitochondrial inner membrane|membrane insertase activity|protein insertion into mitochondrial membrane from inner side|mitochondrial respiratory chain complex IV assembly|protein insertion into mitochondrial membrane hsa04714 Thermogenesis COX19 513.28570907547 557.018717573341 469.552700577599 0.842974725558974 -0.24643871859231 0.190716105444717 1 4.48747 4.94513 3.54059 4.31566 GeneID:90639,Genbank:NM_001031617.2,HGNC:HGNC:28074,MIM:610429 COX19, cytochrome c oxidase assembly factor GO:0005758,GO:0005829,GO:0009060,GO:0033617 mitochondrial intermembrane space|cytosol|aerobic respiration|mitochondrial respiratory chain complex IV assembly hsa04714 Thermogenesis COX20 1528.6563130418 1405.67184358087 1651.64078250273 1.1749831868975 0.232640113085468 0.107904214508817 1 19.7183 21.395 25.7366 24.0128 GeneID:116228,Genbank:NM_001312871.1,HGNC:HGNC:26970,MIM:614698 COX20, cytochrome c oxidase assembly factor GO:0005739,GO:0005743,GO:0009060,GO:0016021,GO:0033617 mitochondrion|mitochondrial inner membrane|aerobic respiration|integral component of membrane|mitochondrial respiratory chain complex IV assembly hsa04714 Thermogenesis COX4I1 7544.63510309724 7425.43068934769 7663.8395168468 1.03210707061627 0.0455926434689988 0.777243356020519 1 101.009 104.66 102.951 113.616 GeneID:1327,Genbank:NM_001318786.1,HGNC:HGNC:2265,MIM:123864 cytochrome c oxidase subunit 4I1 GO:0004129,GO:0005634,GO:0005739,GO:0005743,GO:0005751,GO:0006091,GO:0006123,GO:0007584,GO:0016020,GO:0070062 cytochrome-c oxidase activity|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|response to nutrient|membrane|extracellular exosome hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX4I2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:84701,Genbank:XM_005260581.3,HGNC:HGNC:16232,MIM:607976 cytochrome c oxidase subunit 4I2 GO:0004129,GO:0005751,GO:0006091,GO:0006123,GO:0045333,GO:0055114,GO:0071456 cytochrome-c oxidase activity|mitochondrial respiratory chain complex IV|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|cellular respiration|oxidation-reduction process|cellular response to hypoxia hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX5A 3471.13387951824 3552.9241671717 3389.34359186478 0.9539588891825 -0.0680010001979844 0.609494166375089 1 213.749 218.601 201.515 210.599 GeneID:9377,Genbank:NM_004255.3,HGNC:HGNC:2267,MIM:603773 cytochrome c oxidase subunit 5A GO:0004129,GO:0005743,GO:0005751,GO:0006123,GO:0009055,GO:0043209,GO:0046872,GO:0070062 cytochrome-c oxidase activity|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|mitochondrial electron transport, cytochrome c to oxygen|electron transfer activity|myelin sheath|metal ion binding|extracellular exosome hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX5B 2494.41094593054 2589.26221718678 2399.55967467431 0.926734904926479 -0.109771383915035 0.643834158811886 1 233.265 266.44 203.403 259.195 GeneID:1329,Genbank:NM_001862.2,HGNC:HGNC:2269,MIM:123866 cytochrome c oxidase subunit 5B GO:0004129,GO:0005743,GO:0046872 cytochrome-c oxidase activity|mitochondrial inner membrane|metal ion binding hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX6A1 5766.1868062597 5666.01862245214 5866.35499006726 1.03535752015026 0.0501290319595562 0.79496521202775 1 485.013 509.872 465.457 541.852 GeneID:1337,Genbank:NM_004373.3,HGNC:HGNC:2277,MIM:602072 cytochrome c oxidase subunit 6A1 GO:0004129,GO:0005739,GO:0005743,GO:0005751,GO:0006091,GO:0006123,GO:0009060,GO:0030234 cytochrome-c oxidase activity|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|aerobic respiration|enzyme regulator activity hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX6B1 5769.2880878578 5640.12229038841 5898.4538853272 1.04580248115879 0.0646103980849578 0.686624970956672 1 431.508 456.756 438.004 494.137 GeneID:1340,Genbank:NM_001863.4,HGNC:HGNC:2280,MIM:124089 cytochrome c oxidase subunit 6B1 GO:0004129,GO:0005743,GO:0005758,GO:0006123,GO:0021762 cytochrome-c oxidase activity|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial electron transport, cytochrome c to oxygen|substantia nigra development hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX6B2 3.2378177468211 3.084507235799 3.3911282578432 1.09940680912839 0.136725319785145 1 1 0.0645734 0.0832098 0.059264 0.138628 GeneID:125965,Genbank:NM_144613.4,HGNC:HGNC:24380 cytochrome c oxidase subunit 6B2 GO:0005758,GO:0030061 mitochondrial intermembrane space|mitochondrial crista hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX6C 2703.61736451231 2710.53610818514 2696.69862083948 0.99489492602446 -0.00738392873669308 0.959066945560826 1 62.7311 67.8631 63.0313 72.9117 GeneID:1345,Genbank:NM_004374.3,HGNC:HGNC:2285,MIM:124090 cytochrome c oxidase subunit 6C hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX7A2 4192.3274651673 4209.25387455301 4175.40105578159 0.991957525067309 -0.0116497481529185 0.95872529783524 1 137.006 150.855 123.215 165.333 GeneID:1347,Genbank:NM_001865.3,HGNC:HGNC:2288,MIM:123996 cytochrome c oxidase subunit 7A2 GO:0004129,GO:0005746,GO:0070062 cytochrome-c oxidase activity|mitochondrial respiratory chain|extracellular exosome hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX7A2L 1923.49787816668 1957.03021839393 1889.96553793943 0.965731402701825 -0.0503061044526116 0.723551289936028 1 44.524 44.1852 42.3082 45.0573 GeneID:9167,Genbank:NM_001319038.1,HGNC:HGNC:2289,MIM:605771 cytochrome c oxidase subunit 7A2 like GO:0004129,GO:0005730,GO:0005739,GO:0005743,GO:0005746,GO:0006123 cytochrome-c oxidase activity|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain|mitochondrial electron transport, cytochrome c to oxygen hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX7B 3699.75192232268 3778.80479785105 3620.69904679431 0.958159852250995 -0.0616617303544897 0.765648108964498 1 467.396 488.345 397.185 500.703 GeneID:1349,Genbank:NM_001866.2,HGNC:HGNC:2291,MIM:300885 cytochrome c oxidase subunit 7B GO:0004129,GO:0005739,GO:0005743,GO:0005746,GO:0006123,GO:0007417,GO:0016021,GO:0045277 cytochrome-c oxidase activity|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain|mitochondrial electron transport, cytochrome c to oxygen|central nervous system development|integral component of membrane|respiratory chain complex IV hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX7C 6207.14748753878 6081.18720779745 6333.10776728012 1.0414262134801 0.0585606260157444 0.713639273328472 1 762.632 827.787 788.004 882.472 GeneID:1350,Genbank:NM_001867.2,HGNC:HGNC:2292,MIM:603774 cytochrome c oxidase subunit 7C GO:0004129,GO:0005739,GO:0005743,GO:0005751,GO:0006091,GO:0006123,GO:0016021 cytochrome-c oxidase activity|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|integral component of membrane hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease COX8A 4595.54233315454 4437.77798434174 4753.30668196734 1.07110060456808 0.0990939935288097 0.586592754226523 1 589.435 624.251 601.432 688.774 GeneID:1351,Genbank:NM_004074.2,HGNC:HGNC:2294,MIM:123870 cytochrome c oxidase subunit 8A GO:0004129,GO:0005743,GO:0005751,GO:0006091,GO:0006123,GO:0016021,GO:1902600 cytochrome-c oxidase activity|mitochondrial inner membrane|mitochondrial respiratory chain complex IV|generation of precursor metabolites and energy|mitochondrial electron transport, cytochrome c to oxygen|integral component of membrane|hydrogen ion transmembrane transport hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease CP 13.5369728587798 18.3531559356312 8.72078978192829 0.475165677909245 -1.07349746350123 0.32705250336935 1 0.0886525 0.0268137 0.00536652 0.0199357 GeneID:1356,Genbank:XM_006713499.3,HGNC:HGNC:2295,MIM:117700 ceruloplasmin hsa00860,hsa04216 Porphyrin and chlorophyll metabolism|Ferroptosis CPA1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0259906 GeneID:1357,Genbank:NM_001868.3,HGNC:HGNC:2296,MIM:114850 carboxypeptidase A1 GO:0004181,GO:0005615,GO:0006508,GO:0008270 metallocarboxypeptidase activity|extracellular space|proteolysis|zinc ion binding hsa04972,hsa04974 Pancreatic secretion|Protein digestion and absorption CPA2 7.26638188679357 8.71542403075469 5.81733974283245 0.667476386955405 -0.583211294828606 0.632025529968305 1 0.168438 0.0519113 0.106687 0.0992605 GeneID:1358,Genbank:NM_001869.2,HGNC:HGNC:2297,MIM:600688 carboxypeptidase A2 GO:0004180,GO:0004181,GO:0005576,GO:0005615,GO:0005773,GO:0007039,GO:0008270 carboxypeptidase activity|metallocarboxypeptidase activity|extracellular region|extracellular space|vacuole|protein catabolic process in the vacuole|zinc ion binding hsa04972,hsa04974 Pancreatic secretion|Protein digestion and absorption CPA4 3815.69864164334 5553.2200241111 2078.17725917557 0.37422923099616 -1.41800584318692 6.60538494248283e-23 1.05791845238805e-18 76.1324 86.6808 33.2999 28.7973 GeneID:51200,Genbank:NM_016352.3,HGNC:HGNC:15740,MIM:607635 carboxypeptidase A4 GO:0004181,GO:0005615,GO:0008270,GO:0016573 metallocarboxypeptidase activity|extracellular space|zinc ion binding|histone acetylation CPA5 8.85992493464141 12.8761266198383 4.84372324944452 0.37617859721741 -1.41051032621414 0.16282558520433 1 0.038539 0.0587627 0.0121336 0.0679092 GeneID:93979,Genbank:NM_080385.4,HGNC:HGNC:15722,MIM:609561 carboxypeptidase A5 GO:0004181,GO:0005615,GO:0008270 metallocarboxypeptidase activity|extracellular space|zinc ion binding CPA6 375.808471543121 353.257926566121 398.35901652012 1.12767184134383 0.173347296686196 0.353415563197917 1 3.13508 3.16435 3.72645 3.68216 GeneID:57094,Genbank:NM_020361.4,HGNC:HGNC:17245,MIM:609562 carboxypeptidase A6 GO:0004181,GO:0005578,GO:0005615,GO:0008270 metallocarboxypeptidase activity|proteinaceous extracellular matrix|extracellular space|zinc ion binding CPB1 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0261573 0 0 0.0230988 GeneID:1360,Genbank:NM_001871.2,HGNC:HGNC:2299,MIM:114852 carboxypeptidase B1 GO:0004180,GO:0004181,GO:0005615,GO:0008270 carboxypeptidase activity|metallocarboxypeptidase activity|extracellular space|zinc ion binding hsa04972,hsa04974 Pancreatic secretion|Protein digestion and absorption CPB2 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0 0.0218141 0 GeneID:1361,Genbank:XM_017020393.2,HGNC:HGNC:2300,MIM:603101 carboxypeptidase B2 hsa04610,hsa04972,hsa04974 Complement and coagulation cascades|Pancreatic secretion|Protein digestion and absorption CPD 1644.94321504259 1789.35815533961 1500.52827474557 0.838584645711009 -0.253971679870454 0.208717655399513 1 8.93062 7.57624 7.7934 6.2191 GeneID:1362,Genbank:NM_001304.4,HGNC:HGNC:2301,MIM:603102 carboxypeptidase D GO:0004181,GO:0004185,GO:0005615,GO:0005886,GO:0006518,GO:0008270,GO:0016020,GO:0016021,GO:0016485,GO:0070062 metallocarboxypeptidase activity|serine-type carboxypeptidase activity|extracellular space|plasma membrane|peptide metabolic process|zinc ion binding|membrane|integral component of membrane|protein processing|extracellular exosome CPE 460.056368556387 493.655427896787 426.457309215987 0.863876471556087 -0.211103063302459 0.248290193328103 1 9.08124 8.02928 7.19366 7.3326 GeneID:1363,Genbank:NM_001873.3,HGNC:HGNC:2303,MIM:114855 carboxypeptidase E GO:0003214,GO:0004180,GO:0004181,GO:0004185,GO:0005615,GO:0005634,GO:0005794,GO:0005886,GO:0006464,GO:0007218,GO:0008152,GO:0008270,GO:0016055,GO:0030070,GO:0030141,GO:0030658,GO:0030667,GO:0042043,GO:0043025,GO:0050839,GO:0070062,GO:0072657,GO:0097060 cardiac left ventricle morphogenesis|carboxypeptidase activity|metallocarboxypeptidase activity|serine-type carboxypeptidase activity|extracellular space|nucleus|Golgi apparatus|plasma membrane|cellular protein modification process|neuropeptide signaling pathway|metabolic process|zinc ion binding|Wnt signaling pathway|insulin processing|secretory granule|transport vesicle membrane|secretory granule membrane|neurexin family protein binding|neuronal cell body|cell adhesion molecule binding|extracellular exosome|protein localization to membrane|synaptic membrane hsa04940 Type I diabetes mellitus CPEB1 211.539173912995 201.146737863163 221.931609962827 1.10333188755864 0.14186682584607 0.572303538049219 1 1.8066 2.2015 1.84406 2.42108 GeneID:64506,Genbank:NM_030594.4,HGNC:HGNC:21744,MIM:607342 cytoplasmic polyadenylation element binding protein 1 GO:0000900,GO:0000932,GO:0003730,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0008135,GO:0014069,GO:0030054,GO:0030425,GO:0032869,GO:0035925,GO:0043005,GO:0043022,GO:0045202,GO:0045211,GO:0046872,GO:0071230,GO:0071456,GO:1990124,GO:2000766 translation repressor activity, nucleic acid binding|P-body|mRNA 3'-UTR binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|translation factor activity, RNA binding|postsynaptic density|cell junction|dendrite|cellular response to insulin stimulus|mRNA 3'-UTR AU-rich region binding|neuron projection|ribosome binding|synapse|postsynaptic membrane|metal ion binding|cellular response to amino acid stimulus|cellular response to hypoxia|messenger ribonucleoprotein complex|negative regulation of cytoplasmic translation hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation CPEB2 191.565345993253 175.672833616488 207.457858370018 1.18093306801733 0.239927199133153 0.423368462569676 1 1.00763 1.01272 1.48244 0.900186 GeneID:132864,Genbank:XM_011513779.2,HGNC:HGNC:21745,MIM:610605 cytoplasmic polyadenylation element binding protein 2 GO:0000900,GO:0003723,GO:0003730,GO:0005095,GO:0005634,GO:0005737,GO:0008135,GO:0032869,GO:0034260,GO:0034599,GO:0035925,GO:0043005,GO:0043022,GO:0043023,GO:0043024,GO:0045202,GO:0071243,GO:0071456,GO:1900248,GO:1990124,GO:2000766 translation repressor activity, nucleic acid binding|RNA binding|mRNA 3'-UTR binding|GTPase inhibitor activity|nucleus|cytoplasm|translation factor activity, RNA binding|cellular response to insulin stimulus|negative regulation of GTPase activity|cellular response to oxidative stress|mRNA 3'-UTR AU-rich region binding|neuron projection|ribosome binding|ribosomal large subunit binding|ribosomal small subunit binding|synapse|cellular response to arsenic-containing substance|cellular response to hypoxia|negative regulation of cytoplasmic translational elongation|messenger ribonucleoprotein complex|negative regulation of cytoplasmic translation hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation CPEB3 52.3079152395191 60.0278254113681 44.5880050676702 0.742788944328909 -0.428975752528078 0.284240417229574 1 0.1814 0.194311 0.164811 0.144922 GeneID:22849,Genbank:XM_011539517.2,HGNC:HGNC:21746,MIM:610606 cytoplasmic polyadenylation element binding protein 3 GO:0000122,GO:0000900,GO:0003723,GO:0003730,GO:0005634,GO:0005737,GO:0007616,GO:0008135,GO:0014069,GO:0017148,GO:0030014,GO:0030054,GO:0030425,GO:0035613,GO:0035925,GO:0043005,GO:0043022,GO:0045202,GO:0045211,GO:0045727,GO:0048167,GO:0050955,GO:0060213,GO:0060998,GO:0060999,GO:0061158,GO:0071230,GO:0097440,GO:1900153,GO:1900248,GO:1900273,GO:1900365,GO:1990124 negative regulation of transcription from RNA polymerase II promoter|translation repressor activity, nucleic acid binding|RNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|long-term memory|translation factor activity, RNA binding|postsynaptic density|negative regulation of translation|CCR4-NOT complex|cell junction|dendrite|RNA stem-loop binding|mRNA 3'-UTR AU-rich region binding|neuron projection|ribosome binding|synapse|postsynaptic membrane|positive regulation of translation|regulation of synaptic plasticity|thermoception|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of dendritic spine development|positive regulation of dendritic spine development|3'-UTR-mediated mRNA destabilization|cellular response to amino acid stimulus|apical dendrite|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of cytoplasmic translational elongation|positive regulation of long-term synaptic potentiation|positive regulation of mRNA polyadenylation|messenger ribonucleoprotein complex hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation CPEB4 352.192307575817 393.682895899194 310.701719252439 0.789218232462903 -0.341503809403721 0.203102979559701 1 2.20737 2.02839 1.97012 1.31503 GeneID:80315,Genbank:NM_030627.3,HGNC:HGNC:21747,MIM:610607 cytoplasmic polyadenylation element binding protein 4 GO:0000900,GO:0002931,GO:0003723,GO:0003730,GO:0005634,GO:0005737,GO:0005783,GO:0008135,GO:0014069,GO:0030054,GO:0030424,GO:0030425,GO:0030426,GO:0035235,GO:0036294,GO:0042149,GO:0043005,GO:0043022,GO:0043197,GO:0043524,GO:0045202,GO:0045211,GO:0046872,GO:0048471,GO:0071230,GO:1990124,GO:2000766 translation repressor activity, nucleic acid binding|response to ischemia|RNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|endoplasmic reticulum|translation factor activity, RNA binding|postsynaptic density|cell junction|axon|dendrite|growth cone|ionotropic glutamate receptor signaling pathway|cellular response to decreased oxygen levels|cellular response to glucose starvation|neuron projection|ribosome binding|dendritic spine|negative regulation of neuron apoptotic process|synapse|postsynaptic membrane|metal ion binding|perinuclear region of cytoplasm|cellular response to amino acid stimulus|messenger ribonucleoprotein complex|negative regulation of cytoplasmic translation hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation CPED1 14.3166230366512 13.6161380503283 15.0171080229741 1.10289040603639 0.141289437780373 0.941437865470221 1 0.0394394 0.0871104 0.0326764 0.0810619 GeneID:79974,Genbank:NM_024913.4,HGNC:HGNC:26159 cadherin like and PC-esterase domain containing 1 GO:0005783 endoplasmic reticulum CPLANE1 74.3857058684013 69.2715384636572 79.4998732731455 1.14765566113209 0.198689845415002 0.684002193068439 1 0.142329 0.106798 0.197403 0.08247 GeneID:65250,Genbank:XM_011514089.2,HGNC:HGNC:25801,MIM:614571 ciliogenesis and planar polarity effector 1 GO:0001736,GO:0001822,GO:0003281,GO:0016021,GO:0021549,GO:0035869,GO:0042733,GO:0060021,GO:0060271,GO:0060976,GO:1904491 establishment of planar polarity|kidney development|ventricular septum development|integral component of membrane|cerebellum development|ciliary transition zone|embryonic digit morphogenesis|palate development|cilium assembly|coronary vasculature development|protein localization to ciliary transition zone CPLANE2 67.1100286585894 68.8010843719157 65.4189729452632 0.950842178469601 -0.0727221935850684 0.836242831189085 1 0.959331 1.50548 1.10009 1.23203 GeneID:79363,Genbank:NM_030907.3,HGNC:HGNC:28127 ciliogenesis and planar polarity effector 2 GO:0003924,GO:0005525,GO:0005654,GO:0005737,GO:0006887,GO:0015031,GO:0017157,GO:0031338,GO:0034613,GO:0036064,GO:0060271 GTPase activity|GTP binding|nucleoplasm|cytoplasm|exocytosis|protein transport|regulation of exocytosis|regulation of vesicle fusion|cellular protein localization|ciliary basal body|cilium assembly CPLX1 9.46841753948462 8.76345030543964 10.1733847735296 1.16088805424215 0.215228858184157 0.86805732826826 1 0.266169 0.197688 0.107657 0.327684 GeneID:10815,Genbank:NM_006651.3,HGNC:HGNC:2309,MIM:605032 complexin 1 GO:0005326,GO:0005829,GO:0016079,GO:0019905,GO:0030073,GO:0031201,GO:0098793 neurotransmitter transporter activity|cytosol|synaptic vesicle exocytosis|syntaxin binding|insulin secretion|SNARE complex|presynapse hsa04721 Synaptic vesicle cycle CPLX2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00643344 0 0 GeneID:10814,Genbank:XM_005265799.1,HGNC:HGNC:2310,MIM:605033 complexin 2 GO:0000149,GO:0005634,GO:0005829,GO:0006904,GO:0016079,GO:0017075,GO:0030054,GO:0030425,GO:0031201,GO:0031915,GO:0042629,GO:0043025,GO:0043195,GO:0043303,GO:0045202,GO:0048306,GO:0070033 SNARE binding|nucleus|cytosol|vesicle docking involved in exocytosis|synaptic vesicle exocytosis|syntaxin-1 binding|cell junction|dendrite|SNARE complex|positive regulation of synaptic plasticity|mast cell granule|neuronal cell body|terminal bouton|mast cell degranulation|synapse|calcium-dependent protein binding|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex hsa04721 Synaptic vesicle cycle CPLX3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0155554 0 0 GeneID:594855,Genbank:NM_001030005.2,HGNC:HGNC:27652,MIM:609585 complexin 3 GO:0005326,GO:0005829,GO:0005886,GO:0016079,GO:0019905,GO:0030054,GO:0030073,GO:0046928,GO:0098793 neurotransmitter transporter activity|cytosol|plasma membrane|synaptic vesicle exocytosis|syntaxin binding|cell junction|insulin secretion|regulation of neurotransmitter secretion|presynapse hsa04721 Synaptic vesicle cycle CPN2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0140376 0 GeneID:1370,Genbank:XM_005269280.4,HGNC:HGNC:2313,MIM:603104 carboxypeptidase N subunit 2 GO:0004181,GO:0005576,GO:0030234,GO:0030449,GO:0050821,GO:0070062,GO:0072562 metallocarboxypeptidase activity|extracellular region|enzyme regulator activity|regulation of complement activation|protein stabilization|extracellular exosome|blood microparticle CPNE1 2432.16191403594 2484.33789389236 2379.98593417951 0.957996068099515 -0.0619083601628287 0.651000677106496 1 35.2408 35.951 36.0498 34.0984 GeneID:8904,Genbank:NM_001198863.1,HGNC:HGNC:2314,MIM:604205 copine 1 GO:0001786,GO:0004175,GO:0005215,GO:0005509,GO:0005544,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0006355,GO:0006508,GO:0006629,GO:0010629,GO:0016020,GO:0016192,GO:0031965,GO:0035577,GO:0042803,GO:0043122,GO:0043312,GO:0043392,GO:0045666,GO:0046474,GO:0051059,GO:0051897,GO:0070062,GO:0071277,GO:1901223,GO:1903265,GO:1990138 phosphatidylserine binding|endopeptidase activity|transporter activity|calcium ion binding|calcium-dependent phospholipid binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|proteolysis|lipid metabolic process|negative regulation of gene expression|membrane|vesicle-mediated transport|nuclear membrane|azurophil granule membrane|protein homodimerization activity|regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|negative regulation of DNA binding|positive regulation of neuron differentiation|glycerophospholipid biosynthetic process|NF-kappaB binding|positive regulation of protein kinase B signaling|extracellular exosome|cellular response to calcium ion|negative regulation of NIK/NF-kappaB signaling|positive regulation of tumor necrosis factor-mediated signaling pathway|neuron projection extension CPNE2 1653.14664993757 1602.35213789833 1703.9411619768 1.06339993667791 0.088684285625486 0.559379552655439 1 26.1827 28.4975 30.4592 29.0102 GeneID:221184,Genbank:NM_152727.5,HGNC:HGNC:2315,MIM:604206 copine 2 GO:0005634,GO:0005737,GO:0005886,GO:0070062,GO:0071277 nucleus|cytoplasm|plasma membrane|extracellular exosome|cellular response to calcium ion CPNE3 1646.83956358213 1639.49642689345 1654.18270027082 1.00895779529401 0.0128658277708294 0.916526508537864 1 13.7407 12.6641 15.1345 11.9117 GeneID:8895,Genbank:XM_017013945.2,HGNC:HGNC:2316,MIM:604207 copine 3 GO:0003723,GO:0004674,GO:0005215,GO:0005544,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005925,GO:0006629,GO:0016192,GO:0030054,GO:0030335,GO:0030971,GO:0035577,GO:0038128,GO:0043312,GO:0046474,GO:0048306,GO:0070062,GO:0071277,GO:0071363 RNA binding|protein serine/threonine kinase activity|transporter activity|calcium-dependent phospholipid binding|nucleus|nucleolus|cytoplasm|mitochondrion|cytosol|plasma membrane|focal adhesion|lipid metabolic process|vesicle-mediated transport|cell junction|positive regulation of cell migration|receptor tyrosine kinase binding|azurophil granule membrane|ERBB2 signaling pathway|neutrophil degranulation|glycerophospholipid biosynthetic process|calcium-dependent protein binding|extracellular exosome|cellular response to calcium ion|cellular response to growth factor stimulus CPNE4 8.94987325331639 6.26506702096788 11.6346794856649 1.85707183127108 0.893029619589079 0.365827303836512 1 0.0348492 0.00818832 0.0541006 0.0194089 GeneID:131034,Genbank:NM_153429.1,HGNC:HGNC:2317,MIM:604208 copine 4 GO:0070062 extracellular exosome CPNE5 41.7052344662761 38.8302936133626 44.5801753191896 1.14807721422555 0.199219674099144 0.680968265064767 1 0.117912 0.216476 0.13125 0.148443 GeneID:57699,Genbank:XM_005249247.2,HGNC:HGNC:2318,MIM:604209 copine 5 GO:0043005,GO:0043204,GO:0070062,GO:1903861 neuron projection|perikaryon|extracellular exosome|positive regulation of dendrite extension CPNE7 12.9867036479225 13.856269423753 12.1171378720919 0.874487750023116 -0.193489920122577 0.854292453070857 1 0.0748433 0.0830507 0.0791767 0.0370571 GeneID:27132,Genbank:NM_014427.4,HGNC:HGNC:2320,MIM:605689 copine 7 GO:0005215,GO:0005634,GO:0005737,GO:0005886,GO:0006629,GO:0046474,GO:0070062,GO:0071277 transporter activity|nucleus|cytoplasm|plasma membrane|lipid metabolic process|glycerophospholipid biosynthetic process|extracellular exosome|cellular response to calcium ion CPNE8 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0 0 GeneID:144402,Genbank:XM_017018852.1,HGNC:HGNC:23498 copine 8 GO:0070062 extracellular exosome CPNE9 3.24456079029809 4.06465003971372 2.42447154088245 0.596477314699696 -0.745460824682868 0.730848732445383 1 0.0165819 0.0147096 0.0310477 0.0144673 GeneID:151835,Genbank:NM_001308388.1,HGNC:HGNC:24336 copine family member 9 GO:0005615,GO:0070062,GO:1903861 extracellular space|extracellular exosome|positive regulation of dendrite extension CPO 7.15564665886471 6.07296192222811 8.23833139550132 1.35655904005384 0.439951837844135 0.754055848321553 1 0.00572864 0.0162212 0.0127236 0.011791 GeneID:130749,Genbank:XM_017003372.2,HGNC:HGNC:21011,MIM:609563 carboxypeptidase O GO:0004181,GO:0005615,GO:0008270,GO:0016324,GO:0046658 metallocarboxypeptidase activity|extracellular space|zinc ion binding|apical plasma membrane|anchored component of plasma membrane CPOX 719.353651625369 831.952480721401 606.754822529336 0.729314277665485 -0.455387457119921 0.00497746466206893 0.281051935465501 7.37814 7.12233 5.45947 5.24205 GeneID:1371,Genbank:XM_005247125.4,HGNC:HGNC:2321,MIM:612732 coproporphyrinogen oxidase GO:0004109,GO:0005212,GO:0005739,GO:0005743,GO:0005758,GO:0005829,GO:0006782,GO:0006783,GO:0010039,GO:0010288,GO:0017085,GO:0042803,GO:0046685,GO:0051597 coproporphyrinogen oxidase activity|structural constituent of eye lens|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|response to iron ion|response to lead ion|response to insecticide|protein homodimerization activity|response to arsenic-containing substance|response to methylmercury hsa00860 Porphyrin and chlorophyll metabolism CPPED1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00582667 GeneID:55313,Genbank:NM_001099455.1,HGNC:HGNC:25632,MIM:615603 calcineurin like phosphoesterase domain containing 1 GO:0004721,GO:0005576,GO:0005829,GO:0005886,GO:0035578,GO:0043312,GO:0046872,GO:0070062 phosphoprotein phosphatase activity|extracellular region|cytosol|plasma membrane|azurophil granule lumen|neutrophil degranulation|metal ion binding|extracellular exosome CPQ 624.687066760552 562.207589241025 687.166544280079 1.22226479583413 0.28955686965149 0.0841285774748366 0.963274948662815 11.1062 12.442 14.2076 15.0744 GeneID:10404,Genbank:NM_016134.3,HGNC:HGNC:16910 carboxypeptidase Q GO:0004180,GO:0005615,GO:0005737,GO:0005764,GO:0005783,GO:0005794,GO:0006508,GO:0006590,GO:0042246,GO:0042803,GO:0043171,GO:0043231,GO:0046872,GO:0070062,GO:0070573 carboxypeptidase activity|extracellular space|cytoplasm|lysosome|endoplasmic reticulum|Golgi apparatus|proteolysis|thyroid hormone generation|tissue regeneration|protein homodimerization activity|peptide catabolic process|intracellular membrane-bounded organelle|metal ion binding|extracellular exosome|metallodipeptidase activity CPS1 459.656869859565 473.438038902696 445.875700816435 0.941782586481341 -0.0865340473712516 0.649957902406417 1 2.5736 2.36748 2.46588 2.20262 GeneID:1373,Genbank:NM_001122633.2,HGNC:HGNC:2323,MIM:608307 carbamoyl-phosphate synthase 1 hsa00220,hsa00250,hsa00910 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Nitrogen metabolism CPSF1 2146.94370389585 2118.38715415089 2175.50025364081 1.02696065229531 0.0383809062657398 0.799393413795917 1 14.9248 15.0524 15.8823 15.5097 GeneID:29894,Genbank:XM_006716548.2,HGNC:HGNC:2324,MIM:606027 cleavage and polyadenylation specific factor 1 GO:0000398,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006379,GO:0006388,GO:0006406,GO:0019899,GO:0031124,GO:0035925,GO:0098789 mRNA splicing, via spliceosome|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA export from nucleus|enzyme binding|mRNA 3'-end processing|mRNA 3'-UTR AU-rich region binding|pre-mRNA cleavage required for polyadenylation hsa03015 mRNA surveillance pathway CPSF2 838.510902391358 859.356227609727 817.665577172989 0.951486183380902 -0.071745387744428 0.784719666906811 1 6.64928 5.63095 6.7754 4.91243 GeneID:53981,Genbank:NM_017437.2,HGNC:HGNC:2325,MIM:606028 cleavage and polyadenylation specific factor 2 GO:0000398,GO:0003723,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006379,GO:0006398,GO:0006406,GO:0016020,GO:0031124 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|mRNA 3'-end processing by stem-loop binding and cleavage|mRNA export from nucleus|membrane|mRNA 3'-end processing hsa03015 mRNA surveillance pathway CPSF3 824.190272615412 863.710052298405 784.67049293242 0.908488318324357 -0.138460131010107 0.391962708945318 1 7.18259 6.80473 7.19239 5.61244 GeneID:51692,Genbank:NM_001321834.1,HGNC:HGNC:2326,MIM:606029 cleavage and polyadenylation specific factor 3 GO:0000398,GO:0003723,GO:0004521,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006379,GO:0006398,GO:0006406,GO:0008409,GO:0030529,GO:0031124,GO:0046872 mRNA splicing, via spliceosome|RNA binding|endoribonuclease activity|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|mRNA 3'-end processing by stem-loop binding and cleavage|mRNA export from nucleus|5'-3' exonuclease activity|intracellular ribonucleoprotein complex|mRNA 3'-end processing|metal ion binding hsa03015 mRNA surveillance pathway CPSF4 1231.49128388119 1241.29026951962 1221.69229824276 0.984211612901433 -0.0229595556836194 0.866519349371477 1 7.20733 7.51909 7.15777 7.38768 GeneID:10898,Genbank:XM_017011700.2,HGNC:HGNC:2327,MIM:603052 cleavage and polyadenylation specific factor 4 GO:0003723,GO:0004521,GO:0005847,GO:0006378,GO:0008270,GO:0098789 RNA binding|endoribonuclease activity|mRNA cleavage and polyadenylation specificity factor complex|mRNA polyadenylation|zinc ion binding|pre-mRNA cleavage required for polyadenylation hsa03015,hsa05164 mRNA surveillance pathway|Influenza A CPSF4L 7.80698111312097 10.2816907859967 5.33227144024528 0.518618148632486 -0.947255401839318 0.389166127494048 1 0 0 0 0.0174186 GeneID:642843,Genbank:XM_011525115.2,HGNC:HGNC:33632 cleavage and polyadenylation specific factor 4 like GO:0003723,GO:0004521,GO:0005847,GO:0006378,GO:0046872,GO:0098789 RNA binding|endoribonuclease activity|mRNA cleavage and polyadenylation specificity factor complex|mRNA polyadenylation|metal ion binding|pre-mRNA cleavage required for polyadenylation CPSF6 1795.03400237141 1863.78238185309 1726.28562288973 0.926227031491389 -0.110562232868972 0.449504987471627 1 10.9962 10.7463 10.6423 9.85429 GeneID:11052,Genbank:NM_001300947.1,HGNC:HGNC:13871,MIM:604979 cleavage and polyadenylation specific factor 6 GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005849,GO:0006378,GO:0006397,GO:0016020,GO:0016607,GO:0030529,GO:0042382,GO:0051262 RNA binding|mRNA binding|nucleus|nucleoplasm|mRNA cleavage factor complex|mRNA polyadenylation|mRNA processing|membrane|nuclear speck|intracellular ribonucleoprotein complex|paraspeckles|protein tetramerization hsa03015 mRNA surveillance pathway CPSF7 2444.88723529279 2418.64093406646 2471.13353651912 1.02170334658333 0.0309763679589688 0.831119226903258 1 19.0611 19.1746 20.2823 19.2414 GeneID:79869,Genbank:NM_001142565.1,HGNC:HGNC:30098 cleavage and polyadenylation specific factor 7 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005849,GO:0006369,GO:0016020,GO:0031124,GO:0051262 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|mRNA cleavage factor complex|termination of RNA polymerase II transcription|membrane|mRNA 3'-end processing|protein tetramerization hsa03015 mRNA surveillance pathway CPT1A 5405.78466000095 5053.02488685032 5758.54443315158 1.13962320829594 0.18855690739262 0.157747685459059 1 31.6082 32.5156 39.3187 35.2324 GeneID:1374,Genbank:NM_001031847.2,HGNC:HGNC:2328,MIM:600528 carnitine palmitoyltransferase 1A GO:0001676,GO:0004095,GO:0005739,GO:0005741,GO:0005743,GO:0006006,GO:0006635,GO:0006641,GO:0006853,GO:0007623,GO:0009437,GO:0014070,GO:0016020,GO:0019216,GO:0030855,GO:0031307,GO:0032000,GO:0042493,GO:0042755,GO:0042802,GO:0050796,GO:0051260,GO:0071398,GO:1990698 long-chain fatty acid metabolic process|carnitine O-palmitoyltransferase activity|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|glucose metabolic process|fatty acid beta-oxidation|triglyceride metabolic process|carnitine shuttle|circadian rhythm|carnitine metabolic process|response to organic cyclic compound|membrane|regulation of lipid metabolic process|epithelial cell differentiation|integral component of mitochondrial outer membrane|positive regulation of fatty acid beta-oxidation|response to drug|eating behavior|identical protein binding|regulation of insulin secretion|protein homooligomerization|cellular response to fatty acid|palmitoleoyltransferase activity hsa00071,hsa03320,hsa04152,hsa04714,hsa04920,hsa04922,hsa04931 Fatty acid degradation|PPAR signaling pathway|AMPK signaling pathway|Thermogenesis|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance CPT1B 127.013229594841 129.962940066361 124.063519123321 0.954606898397124 -0.06702133292909 0.789889132164052 1 1.05414 1.36176 1.14931 1.13708 GeneID:1375,Genbank:NM_001145134.1,HGNC:HGNC:2329,MIM:601987 carnitine palmitoyltransferase 1B GO:0004095,GO:0005739,GO:0005741,GO:0006635,GO:0006853,GO:0016021 carnitine O-palmitoyltransferase activity|mitochondrion|mitochondrial outer membrane|fatty acid beta-oxidation|carnitine shuttle|integral component of membrane hsa00071,hsa03320,hsa04152,hsa04714,hsa04920,hsa04922,hsa04931 Fatty acid degradation|PPAR signaling pathway|AMPK signaling pathway|Thermogenesis|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance CPT1C 642.743793690494 585.731016534978 699.75657084601 1.19467221487702 0.256614836749954 0.137401489921961 1 5.21156 5.803 6.37096 7.21529 GeneID:126129,Genbank:XM_024451351.1,HGNC:HGNC:18540,MIM:608846 carnitine palmitoyltransferase 1C GO:0004095,GO:0005741,GO:0005783,GO:0005789,GO:0006635,GO:0009437,GO:0030054,GO:0030424,GO:0030425,GO:0032281,GO:0045202 carnitine O-palmitoyltransferase activity|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid beta-oxidation|carnitine metabolic process|cell junction|axon|dendrite|AMPA glutamate receptor complex|synapse hsa00071,hsa03320,hsa04152,hsa04714,hsa04920,hsa04922 Fatty acid degradation|PPAR signaling pathway|AMPK signaling pathway|Thermogenesis|Adipocytokine signaling pathway|Glucagon signaling pathway CPT2 724.118010365321 659.249501481981 788.986519248661 1.19679501838839 0.259176075190018 0.111144751298831 1 8.70868 9.12812 11.4418 10.4537 GeneID:1376,Genbank:NM_000098.2,HGNC:HGNC:2330,MIM:600650 carnitine palmitoyltransferase 2 GO:0004095,GO:0005654,GO:0005730,GO:0005739,GO:0005743,GO:0006635,GO:0006853,GO:0019216 carnitine O-palmitoyltransferase activity|nucleoplasm|nucleolus|mitochondrion|mitochondrial inner membrane|fatty acid beta-oxidation|carnitine shuttle|regulation of lipid metabolic process hsa00071,hsa03320,hsa04714 Fatty acid degradation|PPAR signaling pathway|Thermogenesis CPTP 730.298150459815 701.193728296466 759.402572623164 1.08301392607734 0.115051794149884 0.498062001159438 1 9.33285 10.3455 11.0406 11.1641 GeneID:80772,Genbank:XM_005244802.2,HGNC:HGNC:28116,MIM:615467 ceramide-1-phosphate transfer protein GO:0005543,GO:0005548,GO:0005640,GO:0005794,GO:0005829,GO:0005886,GO:0006687,GO:0010008,GO:0120013,GO:1902387,GO:1902388,GO:1902389 phospholipid binding|phospholipid transporter activity|nuclear outer membrane|Golgi apparatus|cytosol|plasma membrane|glycosphingolipid metabolic process|endosome membrane|intermembrane lipid transfer activity|ceramide 1-phosphate binding|ceramide 1-phosphate transporter activity|ceramide 1-phosphate transport CPVL 803.143942192084 792.143061304978 814.144823079189 1.02777498516236 0.0395244441778793 0.819048832423919 1 8.24199 9.09002 8.89221 8.98855 GeneID:54504,Genbank:NM_001348054.1,HGNC:HGNC:14399,MIM:609780 carboxypeptidase, vitellogenic like GO:0004185,GO:0051603,GO:0070062 serine-type carboxypeptidase activity|proteolysis involved in cellular protein catabolic process|extracellular exosome CRABP1 5.20786879946075 4.60274771635603 5.81298988256547 1.2629390617932 0.336785029173189 0.871809604167565 1 0.26681 0.295814 0.185383 0.518714 GeneID:1381,Genbank:NM_004378.2,HGNC:HGNC:2338,MIM:180230 cellular retinoic acid binding protein 1 GO:0001972,GO:0005501,GO:0005829,GO:0007165,GO:0007275,GO:0016918,GO:0019841,GO:0034653 retinoic acid binding|retinoid binding|cytosol|signal transduction|multicellular organism development|retinal binding|retinol binding|retinoic acid catabolic process CRABP2 180.378381774452 212.446789072651 148.309974476252 0.698104099966103 -0.518485910448593 0.028506578477467 0.6711497109187 6.63331 6.36804 5.0964 4.07207 GeneID:1382,Genbank:NM_001199723.1,HGNC:HGNC:2339,MIM:180231 cellular retinoic acid binding protein 2 GO:0001972,GO:0005501,GO:0005654,GO:0005783,GO:0005829,GO:0006355,GO:0007165,GO:0008544,GO:0016918,GO:0019841,GO:0035115,GO:0042573,GO:0048385,GO:0048672,GO:0070062 retinoic acid binding|retinoid binding|nucleoplasm|endoplasmic reticulum|cytosol|regulation of transcription, DNA-templated|signal transduction|epidermis development|retinal binding|retinol binding|embryonic forelimb morphogenesis|retinoic acid metabolic process|regulation of retinoic acid receptor signaling pathway|positive regulation of collateral sprouting|extracellular exosome CRACR2A 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00638371 0 GeneID:84766,Genbank:XM_011521034.3,HGNC:HGNC:28657,MIM:614178 calcium release activated channel regulator 2A GO:0002115,GO:0002250,GO:0005509,GO:0005576,GO:0005737,GO:0016020,GO:0032237,GO:0035580,GO:0043312,GO:0051928 store-operated calcium entry|adaptive immune response|calcium ion binding|extracellular region|cytoplasm|membrane|activation of store-operated calcium channel activity|specific granule lumen|neutrophil degranulation|positive regulation of calcium ion transport CRACR2B 1.24125200715389 1.02816907859967 1.45433493570811 1.4144900541931 0.500282032643154 1 1 0 0.011643 0.0252746 0 GeneID:283229,Genbank:XM_017017587.1,HGNC:HGNC:28703,MIM:614177 calcium release activated channel regulator 2B GO:0002115,GO:0005509,GO:0005737,GO:0034613,GO:2001256 store-operated calcium entry|calcium ion binding|cytoplasm|cellular protein localization|regulation of store-operated calcium entry CRADD 217.48102734942 229.483618281573 205.478436417266 0.895394790948201 -0.159404169649097 0.480249755690558 1 1.38777 1.35538 1.23178 1.21727 GeneID:8738,Genbank:XM_024449252.1,HGNC:HGNC:2340,MIM:603454 CASP2 and RIPK1 domain containing adaptor with death domain GO:0002020,GO:0005634,GO:0005737,GO:0005829,GO:0006919,GO:0006977,GO:0008625,GO:0030674,GO:0042981,GO:0043065,GO:0070513,GO:0071260,GO:2001235 protease binding|nucleus|cytoplasm|cytosol|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|extrinsic apoptotic signaling pathway via death domain receptors|protein binding, bridging|regulation of apoptotic process|positive regulation of apoptotic process|death domain binding|cellular response to mechanical stimulus|positive regulation of apoptotic signaling pathway CRAMP1 559.703794784193 563.025052911523 556.382536656863 0.988202094701984 -0.0171219810034138 0.891021222587629 1 2.72041 3.22901 3.21736 2.82083 GeneID:57585,Genbank:NM_020825.3,HGNC:HGNC:14122 cramped chromatin regulator homolog 1 GO:0003677,GO:0003682,GO:0005634 DNA binding|chromatin binding|nucleus CRAT 1319.48044205266 1247.14271737864 1391.81816672668 1.11600552794161 0.158344173326779 0.29421715315694 1 12.1062 12.6005 14.1357 14.4368 GeneID:1384,Genbank:NM_001346549.1,HGNC:HGNC:2342,MIM:600184 carnitine O-acetyltransferase GO:0004092,GO:0005102,GO:0005739,GO:0005743,GO:0005777,GO:0005782,GO:0005783,GO:0019254,GO:0033540 carnitine O-acetyltransferase activity|receptor binding|mitochondrion|mitochondrial inner membrane|peroxisome|peroxisomal matrix|endoplasmic reticulum|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA oxidase hsa04146 Peroxisome CRB1 3.96542020070186 3.084507235799 4.84633316560471 1.57118553957593 0.651853556966049 0.737432801993054 1 0.00695693 0.0196355 0.0133428 0.0123909 GeneID:23418,Genbank:NM_001257965.1,HGNC:HGNC:2343,MIM:604210 crumbs 1, cell polarity complex component hsa04390 Hippo signaling pathway CRB2 3.42862748213965 2.00831188251439 4.84894308176491 2.41443728137189 1.27168698783073 0.512531225080143 1 0.00750429 0.0128159 0.0552833 0.00646698 GeneID:286204,Genbank:XM_011518558.3,HGNC:HGNC:18688,MIM:609720 crumbs 2, cell polarity complex component GO:0001707,GO:0001756,GO:0005509,GO:0010470,GO:0010718,GO:0010951,GO:0014028,GO:0016021,GO:0016324,GO:0019899,GO:0030513,GO:0043234,GO:0045121,GO:0045199,GO:0055111,GO:0070062,GO:0072358 mesoderm formation|somitogenesis|calcium ion binding|regulation of gastrulation|positive regulation of epithelial to mesenchymal transition|negative regulation of endopeptidase activity|notochord formation|integral component of membrane|apical plasma membrane|enzyme binding|positive regulation of BMP signaling pathway|protein complex|membrane raft|maintenance of epithelial cell apical/basal polarity|ingression involved in gastrulation with mouth forming second|extracellular exosome|cardiovascular system development hsa04390 Hippo signaling pathway CRB3 1.94059982990028 0.490071401957362 3.3911282578432 6.91966159277795 2.7907014843419 0.357562461262114 1 0 0.0349902 0 0.0356932 GeneID:92359,Genbank:NM_174882.2,HGNC:HGNC:20237,MIM:609737 crumbs 3, cell polarity complex component GO:0005886,GO:0005923,GO:0016021,GO:0016324,GO:0017124,GO:0019904,GO:0030054,GO:0043234,GO:0070062,GO:0070830,GO:0072659 plasma membrane|bicellular tight junction|integral component of membrane|apical plasma membrane|SH3 domain binding|protein domain specific binding|cell junction|protein complex|extracellular exosome|bicellular tight junction assembly|protein localization to plasma membrane hsa04530,hsa05165 Tight junction|Human papillomavirus infection CRBN 533.610624183619 595.703915361794 471.517333005443 0.791529685882746 -0.337284636031288 0.0517253489563853 0.831760229804686 5.16498 5.22894 3.99342 4.19804 GeneID:51185,Genbank:XM_011533791.3,HGNC:HGNC:30185,MIM:609262 cereblon CRCP 1791.23185057963 1850.45643545258 1732.00726570669 0.935989214619412 -0.0954361891222054 0.499831665962238 1 25.737 26.9905 24.473 25.2153 GeneID:27297,Genbank:NM_014478.4,HGNC:HGNC:17888,MIM:606121 CGRP receptor component GO:0000166,GO:0001635,GO:0001669,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0005886,GO:0006383,GO:0006384,GO:0007218,GO:0009360,GO:0032481,GO:0045087,GO:0051607 nucleotide binding|calcitonin gene-related peptide receptor activity|acrosomal vesicle|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|plasma membrane|transcription from RNA polymerase III promoter|transcription initiation from RNA polymerase III promoter|neuropeptide signaling pathway|DNA polymerase III complex|positive regulation of type I interferon production|innate immune response|defense response to virus CREB1 426.296282438332 488.111771996948 364.480792879717 0.746715842128873 -0.421368755680238 0.0198888767934477 0.575358402571021 1.2461 1.42727 1.18996 0.816485 GeneID:1385,Genbank:NM_134442.4,HGNC:HGNC:2345,MIM:123810 cAMP responsive element binding protein 1 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0007623,GO:0030154,GO:0033762,GO:0045600,GO:0045893,GO:0045944,GO:0046889,GO:0050821 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|circadian rhythm|cell differentiation|response to glucagon|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of lipid biosynthetic process|protein stabilization hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04380,hsa04612,hsa04668,hsa04710,hsa04713,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04962,hsa05016,hsa05030,hsa05031,hsa05034,hsa05152,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05203,hsa05215 cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|Osteoclast differentiation|Antigen processing and presentation|TNF signaling pathway|Circadian rhythm|Circadian entrainment|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Vasopressin-regulated water reabsorption|Huntington disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Viral carcinogenesis|Prostate cancer CREB3 3029.58292987887 2781.79735822195 3277.36850153579 1.17814782297104 0.236520566407371 0.0857616645332753 0.964561165794104 57.7177 61.2203 68.8672 73.9716 GeneID:10488,Genbank:NM_006368.4,HGNC:HGNC:2347,MIM:606443 cAMP responsive element binding protein 3 GO:0000139,GO:0000977,GO:0000978,GO:0000982,GO:0001077,GO:0001558,GO:0002230,GO:0003677,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006351,GO:0006935,GO:0006990,GO:0008140,GO:0016020,GO:0016021,GO:0016032,GO:0016604,GO:0019043,GO:0019046,GO:0030176,GO:0030335,GO:0030968,GO:0031726,GO:0034976,GO:0035497,GO:0042127,GO:0042803,GO:0042981,GO:0042994,GO:0043025,GO:0045786,GO:0045893,GO:0045944,GO:0046983,GO:0050930,GO:0051928,GO:0090026,GO:0090045,GO:1902236,GO:2000326 Golgi membrane|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|regulation of cell growth|positive regulation of defense response to virus by host|DNA binding|chromatin binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|transcription, DNA-templated|chemotaxis|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|cAMP response element binding protein binding|membrane|integral component of membrane|viral process|nuclear body|establishment of viral latency|release from viral latency|integral component of endoplasmic reticulum membrane|positive regulation of cell migration|endoplasmic reticulum unfolded protein response|CCR1 chemokine receptor binding|response to endoplasmic reticulum stress|cAMP response element binding|regulation of cell proliferation|protein homodimerization activity|regulation of apoptotic process|cytoplasmic sequestering of transcription factor|neuronal cell body|negative regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|induction of positive chemotaxis|positive regulation of calcium ion transport|positive regulation of monocyte chemotaxis|positive regulation of deacetylase activity|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of ligand-dependent nuclear receptor transcription coactivator activity hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04962,hsa05016,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05203,hsa05215 cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Vasopressin-regulated water reabsorption|Huntington disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Viral carcinogenesis|Prostate cancer CREB3L1 17.0125495052596 19.9772576206661 14.0478413898532 0.703191682091589 -0.508010089645222 0.478577027400981 1 0.197918 0.182711 0.064519 0.110947 GeneID:90993,Genbank:NM_052854.3,HGNC:HGNC:18856,MIM:616215 cAMP responsive element binding protein 3 like 1 GO:0001077,GO:0001649,GO:0003682,GO:0005634,GO:0005783,GO:0005789,GO:0007275,GO:0016020,GO:0016021,GO:0030968,GO:0032967,GO:0035497,GO:0044212,GO:0046332,GO:0070278,GO:1902236,GO:1990440 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|osteoblast differentiation|chromatin binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|multicellular organism development|membrane|integral component of membrane|endoplasmic reticulum unfolded protein response|positive regulation of collagen biosynthetic process|cAMP response element binding|transcription regulatory region DNA binding|SMAD binding|extracellular matrix constituent secretion|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04962,hsa05016,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05203,hsa05215 cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Vasopressin-regulated water reabsorption|Huntington disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Viral carcinogenesis|Prostate cancer CREB3L2 1083.67117215473 1024.50825606765 1142.83408824181 1.11549524513187 0.157684364017477 0.289593052527275 1 4.26805 4.01734 5.20357 4.22255 GeneID:64764,Genbank:NM_194071.3,HGNC:HGNC:23720,MIM:608834 cAMP responsive element binding protein 3 like 2 hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04962,hsa05016,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05203,hsa05215 cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Vasopressin-regulated water reabsorption|Huntington disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Viral carcinogenesis|Prostate cancer CREB3L3 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00828813 0 GeneID:84699,Genbank:NM_032607.2,HGNC:HGNC:18855,MIM:611998 cAMP responsive element binding protein 3 like 3 GO:0000139,GO:0000976,GO:0000977,GO:0001228,GO:0002675,GO:0005634,GO:0005654,GO:0005783,GO:0005789,GO:0005829,GO:0016020,GO:0016021,GO:0030968,GO:0035497,GO:0042803,GO:0045944,GO:0046982,GO:1990440 Golgi membrane|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|positive regulation of acute inflammatory response|nucleus|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|membrane|integral component of membrane|endoplasmic reticulum unfolded protein response|cAMP response element binding|protein homodimerization activity|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04962,hsa05016,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05203,hsa05215 cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Vasopressin-regulated water reabsorption|Huntington disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Viral carcinogenesis|Prostate cancer CREB3L4 111.596523276972 97.6760624669683 125.516984086975 1.28503320994765 0.361805644405664 0.201710360011872 1 1.35528 1.34108 1.70284 1.85608 GeneID:148327,Genbank:XM_024453343.1,HGNC:HGNC:18854,MIM:607138 cAMP responsive element binding protein 3 like 4 GO:0000139,GO:0001228,GO:0005654,GO:0005739,GO:0005783,GO:0005789,GO:0005794,GO:0007283,GO:0016021,GO:0030968,GO:0031965,GO:0035497,GO:0045944 Golgi membrane|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|spermatogenesis|integral component of membrane|endoplasmic reticulum unfolded protein response|nuclear membrane|cAMP response element binding|positive regulation of transcription from RNA polymerase II promoter hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04916,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04962,hsa05016,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05203,hsa05215 cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Vasopressin-regulated water reabsorption|Huntington disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Viral carcinogenesis|Prostate cancer CREB5 147.824587611547 153.629429183515 142.01974603958 0.924430604177622 -0.113363072463447 0.728106748075556 1 0.482696 0.402228 0.523821 0.354783 GeneID:9586,Genbank:NM_182899.4,HGNC:HGNC:16844 cAMP responsive element binding protein 5 GO:0001077,GO:0003677,GO:0003700,GO:0005634,GO:0045444,GO:0045893,GO:0045944,GO:0060612 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|adipose tissue development hsa04022,hsa04024,hsa04151,hsa04152,hsa04211,hsa04261,hsa04668,hsa04714,hsa04725,hsa04728,hsa04911,hsa04915,hsa04918,hsa04922,hsa04925,hsa04926,hsa04927,hsa04928,hsa04931,hsa04934,hsa04962,hsa05016,hsa05030,hsa05031,hsa05034,hsa05161,hsa05163,hsa05165,hsa05203,hsa05215 cGMP-PKG signaling pathway|cAMP signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Thermogenesis|Cholinergic synapse|Dopaminergic synapse|Insulin secretion|Estrogen signaling pathway|Thyroid hormone synthesis|Glucagon signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|Cushing syndrome|Vasopressin-regulated water reabsorption|Huntington disease|Cocaine addiction|Amphetamine addiction|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Viral carcinogenesis|Prostate cancer CREBBP 1282.03312651465 1220.58179212271 1343.48446090659 1.10069187462656 0.138410660398228 0.347990082708545 1 3.50144 3.4126 4.45645 3.56011 GeneID:1387,Genbank:NM_001079846.1,HGNC:HGNC:2348,MIM:600140 CREB binding protein hsa04024,hsa04066,hsa04068,hsa04110,hsa04310,hsa04330,hsa04350,hsa04520,hsa04630,hsa04720,hsa04916,hsa04919,hsa04922,hsa05016,hsa05152,hsa05161,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05200,hsa05203,hsa05206,hsa05211,hsa05215 cAMP signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|Wnt signaling pathway|Notch signaling pathway|TGF-beta signaling pathway|Adherens junction|Jak-STAT signaling pathway|Long-term potentiation|Melanogenesis|Thyroid hormone signaling pathway|Glucagon signaling pathway|Huntington disease|Tuberculosis|Hepatitis B|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Renal cell carcinoma|Prostate cancer CREBL2 1021.09877686372 947.404366826926 1094.79318690051 1.15557118505503 0.208606134892196 0.159706082755626 1 11.9183 10.7787 13.7199 12.6707 GeneID:1389,Genbank:NM_001310.3,HGNC:HGNC:2350,MIM:603476 cAMP responsive element binding protein like 2 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0007049,GO:0007165,GO:0030154,GO:0033138,GO:0045600,GO:0045893,GO:0046326,GO:0046889,GO:0050821 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|cell cycle|signal transduction|cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of glucose import|positive regulation of lipid biosynthetic process|protein stabilization CREBRF 46.5967819550598 49.0923670891434 44.1011968209762 0.898331032620528 -0.154680922620413 0.847463860809384 1 0.25317 0.12854 0.184268 0.171316 GeneID:153222,Genbank:XM_005265821.3,HGNC:HGNC:24050,MIM:617109 CREB3 regulatory factor GO:0000122,GO:0000977,GO:0001228,GO:0005634,GO:0005654,GO:0005737,GO:0016604,GO:0030968,GO:0032388,GO:0034976,GO:0042711,GO:0045732,GO:0045944,GO:0051222,GO:1900102,GO:1900170,GO:1902213 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|nucleoplasm|cytoplasm|nuclear body|endoplasmic reticulum unfolded protein response|positive regulation of intracellular transport|response to endoplasmic reticulum stress|maternal behavior|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of protein transport|negative regulation of endoplasmic reticulum unfolded protein response|negative regulation of glucocorticoid mediated signaling pathway|positive regulation of prolactin signaling pathway CREBZF 1011.83420502319 1099.40090267115 924.267507375224 0.840701062851216 -0.25033519786661 0.105376624923327 1 7.44977 7.16955 6.97269 5.33162 GeneID:58487,Genbank:NM_001039618.2,HGNC:HGNC:24905,MIM:606444 CREB/ATF bZIP transcription factor GO:0003677,GO:0003700,GO:0005634,GO:0005739,GO:0006351,GO:0009615,GO:0042802,GO:0045814,GO:0045892,GO:0051090 DNA binding|DNA binding transcription factor activity|nucleus|mitochondrion|transcription, DNA-templated|response to virus|identical protein binding|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|regulation of DNA binding transcription factor activity CREG1 281.028120534825 256.735511692446 305.320729377204 1.18924229595071 0.250042679385118 0.235445785488948 1 4.94138 6.2615 6.90202 6.36575 GeneID:8804,Genbank:NM_003851.2,HGNC:HGNC:2351 cellular repressor of E1A stimulated genes 1 GO:0003714,GO:0005576,GO:0005615,GO:0005667,GO:0006357,GO:0007275,GO:0008134,GO:0008283,GO:0035578,GO:0040008,GO:0043312,GO:0048037,GO:0070062 transcription corepressor activity|extracellular region|extracellular space|transcription factor complex|regulation of transcription from RNA polymerase II promoter|multicellular organism development|transcription factor binding|cell proliferation|azurophil granule lumen|regulation of growth|neutrophil degranulation|cofactor binding|extracellular exosome CREG2 129.386586748554 127.444939471674 131.328234025434 1.03047037073311 0.0433030234497577 0.878393353351464 1 0.834788 0.781204 0.761563 0.816658 GeneID:200407,Genbank:NM_153836.3,HGNC:HGNC:14272 cellular repressor of E1A stimulated genes 2 GO:0005576,GO:0005783,GO:0005794,GO:0048037 extracellular region|endoplasmic reticulum|Golgi apparatus|cofactor binding CRELD1 464.711256500961 403.148140015547 526.274372986376 1.30541188399401 0.384505078244201 0.0295964367540397 0.682038174176547 4.85269 4.66802 5.98786 6.48305 GeneID:78987,Genbank:XM_011534108.1,HGNC:HGNC:14630,MIM:607170 cysteine rich with EGF like domains 1 GO:0003197,GO:0003279,GO:0005509,GO:0016021 endocardial cushion development|cardiac septum development|calcium ion binding|integral component of membrane CRELD2 528.465443643493 490.898312929529 566.032574357456 1.15305463361556 0.205460871861243 0.233670093899066 1 3.63037 3.34714 4.20586 4.42154 GeneID:79174,Genbank:NM_001135101.2,HGNC:HGNC:28150,MIM:607171 cysteine rich with EGF like domains 2 GO:0005509,GO:0005615,GO:0005783,GO:0005794 calcium ion binding|extracellular space|endoplasmic reticulum|Golgi apparatus CREM 310.195254601236 333.97265410126 286.417855101212 0.857608704137707 -0.221608546656299 0.264678400077108 1 1.46442 1.52629 1.42506 1.17867 GeneID:1390,Genbank:XM_017015734.2,HGNC:HGNC:2352,MIM:123812 cAMP responsive element modulator GO:0000122,GO:0000977,GO:0001227,GO:0003677,GO:0005634,GO:0005667,GO:0005737,GO:0006006,GO:0006351,GO:0006355,GO:0006631,GO:0006687,GO:0007165,GO:0007275,GO:0007283,GO:0008140,GO:0030154,GO:0042752,GO:0045944,GO:0048384,GO:0048511 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|nucleus|transcription factor complex|cytoplasm|glucose metabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|fatty acid metabolic process|glycosphingolipid metabolic process|signal transduction|multicellular organism development|spermatogenesis|cAMP response element binding protein binding|cell differentiation|regulation of circadian rhythm|positive regulation of transcription from RNA polymerase II promoter|retinoic acid receptor signaling pathway|rhythmic process hsa04261,hsa05166 Adrenergic signaling in cardiomyocytes|Human T-cell leukemia virus 1 infection CRHBP 16.9970193555009 20.9093741498959 13.084664561106 0.625779828095486 -0.676272940584095 0.331773485844228 1 0.427864 0.439708 0.28584 0.310986 GeneID:1393,Genbank:NM_001882.3,HGNC:HGNC:2356,MIM:122559 corticotropin releasing hormone binding protein GO:0001963,GO:0002125,GO:0005576,GO:0005615,GO:0005622,GO:0005634,GO:0005767,GO:0005771,GO:0005874,GO:0006954,GO:0007165,GO:0007565,GO:0007611,GO:0009755,GO:0030141,GO:0030425,GO:0031045,GO:0033554,GO:0035690,GO:0035865,GO:0042277,GO:0042445,GO:0043196,GO:0043204,GO:0043679,GO:0045055,GO:0048149,GO:0051424,GO:0051459,GO:0051460,GO:0071277,GO:0071314,GO:0071320,GO:0071356,GO:0071391,GO:0071392,GO:0097211,GO:1900011,GO:2000310 synaptic transmission, dopaminergic|maternal aggressive behavior|extracellular region|extracellular space|intracellular|nucleus|secondary lysosome|multivesicular body|microtubule|inflammatory response|signal transduction|female pregnancy|learning or memory|hormone-mediated signaling pathway|secretory granule|dendrite|dense core granule|cellular response to stress|cellular response to drug|cellular response to potassium ion|peptide binding|hormone metabolic process|varicosity|perikaryon|axon terminus|regulated exocytosis|behavioral response to ethanol|corticotropin-releasing hormone binding|regulation of corticotropin secretion|negative regulation of corticotropin secretion|cellular response to calcium ion|cellular response to cocaine|cellular response to cAMP|cellular response to tumor necrosis factor|cellular response to estrogen stimulus|cellular response to estradiol stimulus|cellular response to gonadotropin-releasing hormone|negative regulation of corticotropin-releasing hormone receptor activity|regulation of NMDA receptor activity CRIM1 5627.24517533015 5616.89072739254 5637.59962326776 1.00368689669789 0.00530928619057387 0.979529363851268 1 21.9071 21.9018 26.802 17.9929 GeneID:51232,Genbank:XM_017004259.1,HGNC:HGNC:2359,MIM:606189 cysteine rich transmembrane BMP regulator 1 GO:0001558,GO:0004867,GO:0005010,GO:0005520,GO:0005886,GO:0007399,GO:0016021,GO:0030165,GO:0070062 regulation of cell growth|serine-type endopeptidase inhibitor activity|insulin-like growth factor-activated receptor activity|insulin-like growth factor binding|plasma membrane|nervous system development|integral component of membrane|PDZ domain binding|extracellular exosome CRIP1 1.45846806302491 0.980142803914724 1.93679332213509 1.97603177251261 0.982606144127986 0.869541181612543 1 0 0 0 0 GeneID:1396,Genbank:NM_001311.4,HGNC:HGNC:2360,MIM:123875 cysteine rich protein 1 GO:0003680,GO:0005737,GO:0006955,GO:0007507,GO:0008270,GO:0008283,GO:0008301,GO:0008630,GO:0010033,GO:0010043,GO:0010468,GO:0042277,GO:0060741,GO:0071236,GO:0071493 AT DNA binding|cytoplasm|immune response|heart development|zinc ion binding|cell proliferation|DNA binding, bending|intrinsic apoptotic signaling pathway in response to DNA damage|response to organic substance|response to zinc ion|regulation of gene expression|peptide binding|prostate gland stromal morphogenesis|cellular response to antibiotic|cellular response to UV-B CRIP2 267.341197640642 259.444600385018 275.237794896265 1.06087309000769 0.0852520800344082 0.68323728475536 1 3.99489 3.10942 3.79923 4.85418 GeneID:1397,Genbank:NM_001270837.1,HGNC:HGNC:2361,MIM:601183 cysteine rich protein 2 GO:0005938,GO:0008270,GO:0008284,GO:0030097 cell cortex|zinc ion binding|positive regulation of cell proliferation|hemopoiesis CRIPAK 63.3651849207119 65.6587422063238 61.0716276351 0.930137032524786 -0.104484817827518 0.792514423291313 1 0.877948 0.908407 1.04682 0.733182 GeneID:285464,Genbank:NM_175918.3,HGNC:HGNC:26619,MIM:610203 cysteine rich PAK1 inhibitor GO:0005634,GO:0005737,GO:0005783,GO:0005886,GO:0006469,GO:0033147,GO:0043627,GO:0051493 nucleus|cytoplasm|endoplasmic reticulum|plasma membrane|negative regulation of protein kinase activity|negative regulation of intracellular estrogen receptor signaling pathway|response to estrogen|regulation of cytoskeleton organization CRIPT 285.413900738518 314.427632952758 256.400168524278 0.815450493700093 -0.294330801839066 0.150533786435076 1 2.57908 2.5579 2.48728 1.77444 GeneID:9419,Genbank:NM_014171.5,HGNC:HGNC:14312,MIM:604594 CXXC repeat containing interactor of PDZ3 domain GO:0001650,GO:0005634,GO:0005730,GO:0005737,GO:0008017,GO:0014069,GO:0030054,GO:0030165,GO:0030425,GO:0031122,GO:0032403,GO:0035372,GO:0043025,GO:0043197,GO:0043198,GO:0045184,GO:0097110,GO:1902897 fibrillar center|nucleus|nucleolus|cytoplasm|microtubule binding|postsynaptic density|cell junction|PDZ domain binding|dendrite|cytoplasmic microtubule organization|protein complex binding|protein localization to microtubule|neuronal cell body|dendritic spine|dendritic shaft|establishment of protein localization|scaffold protein binding|regulation of postsynaptic density protein 95 clustering CRISPLD1 165.003839774629 179.775701275779 150.231978273479 0.835663425075566 -0.259006100843452 0.303830583593456 1 1.52284 1.35837 1.2637 1.25545 GeneID:83690,Genbank:NM_031461.5,HGNC:HGNC:18206 cysteine rich secretory protein LCCL domain containing 1 GO:0060325,GO:0070062 face morphogenesis|extracellular exosome CRISPLD2 30.9776785138437 39.1762861912651 22.7790708364223 0.581450490871213 -0.782271740016718 0.120678992511122 1 0.24398 0.316049 0.205649 0.153502 GeneID:83716,Genbank:NM_031476.3,HGNC:HGNC:25248,MIM:612434 cysteine rich secretory protein LCCL domain containing 2 GO:0005576,GO:0005578,GO:0008201,GO:0030133,GO:0030198,GO:0030324,GO:0034774,GO:0043312,GO:0060325,GO:0070062,GO:1904813 extracellular region|proteinaceous extracellular matrix|heparin binding|transport vesicle|extracellular matrix organization|lung development|secretory granule lumen|neutrophil degranulation|face morphogenesis|extracellular exosome|ficolin-1-rich granule lumen CRK 2593.45719134279 2790.33520945991 2396.57917322567 0.858885758635983 -0.219461845258187 0.117099786374971 1 35.0192 31.9581 30.9922 27.3161 GeneID:1398,Genbank:NM_005206.4,HGNC:HGNC:2362,MIM:164762 CRK proto-oncogene, adaptor protein hsa04010,hsa04012,hsa04015,hsa04062,hsa04510,hsa04666,hsa04722,hsa04810,hsa04910,hsa05100,hsa05131,hsa05163,hsa05170,hsa05200,hsa05206,hsa05211,hsa05220 MAPK signaling pathway|ErbB signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Focal adhesion|Fc gamma R-mediated phagocytosis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|Bacterial invasion of epithelial cells|Shigellosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Renal cell carcinoma|Chronic myeloid leukemia CRKL 2216.80228790767 2277.47399533998 2156.13058047535 0.946720175460658 -0.07899002730447 0.566553103927445 1 19.6648 20.4115 19.9159 18.5813 GeneID:1399,Genbank:NM_005207.3,HGNC:HGNC:2363,MIM:602007 CRK like proto-oncogene, adaptor protein GO:0000186,GO:0001568,GO:0001784,GO:0003723,GO:0004871,GO:0005070,GO:0005654,GO:0005768,GO:0005829,GO:0007254,GO:0007265,GO:0007507,GO:0008284,GO:0009887,GO:0009952,GO:0019221,GO:0035556,GO:0042802,GO:0045296,GO:0048538,GO:0060017,GO:0070062,GO:1900026 activation of MAPKK activity|blood vessel development|phosphotyrosine residue binding|RNA binding|signal transducer activity|SH3/SH2 adaptor activity|nucleoplasm|endosome|cytosol|JNK cascade|Ras protein signal transduction|heart development|positive regulation of cell proliferation|animal organ morphogenesis|anterior/posterior pattern specification|cytokine-mediated signaling pathway|intracellular signal transduction|identical protein binding|cadherin binding|thymus development|parathyroid gland development|extracellular exosome|positive regulation of substrate adhesion-dependent cell spreading hsa04010,hsa04012,hsa04015,hsa04062,hsa04510,hsa04666,hsa04722,hsa04810,hsa04910,hsa05100,hsa05131,hsa05163,hsa05170,hsa05200,hsa05206,hsa05211,hsa05220 MAPK signaling pathway|ErbB signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Focal adhesion|Fc gamma R-mediated phagocytosis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|Bacterial invasion of epithelial cells|Shigellosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Renal cell carcinoma|Chronic myeloid leukemia CRLF1 7.01460314233791 7.24520982488261 6.7839964597932 0.936342303917074 -0.0948920545181309 1 1 0.0971224 0.0831719 0.0893778 0.0502066 GeneID:9244,Genbank:NM_004750.4,HGNC:HGNC:2364,MIM:604237 cytokine receptor like factor 1 GO:0001657,GO:0005576,GO:0005615,GO:0005829,GO:0008284,GO:0010469,GO:0019221,GO:0019955,GO:0042531,GO:0043524,GO:0046982,GO:0070106,GO:0097058,GO:2000672 ureteric bud development|extracellular region|extracellular space|cytosol|positive regulation of cell proliferation|regulation of receptor activity|cytokine-mediated signaling pathway|cytokine binding|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of neuron apoptotic process|protein heterodimerization activity|interleukin-27-mediated signaling pathway|CRLF-CLCF1 complex|negative regulation of motor neuron apoptotic process CRLF2 2.98595313674402 5.48683797090087 0.48506830258717 0.0884058004190578 -3.49971515996256 0.140566370296276 1 0 0.116482 0.0202464 0 GeneID:64109,Genbank:XM_011546181.2,HGNC:HGNC:14281,MIM:400023 cytokine receptor like factor 2 GO:0004896,GO:0005576,GO:0005886,GO:0008284,GO:0016021,GO:0019221,GO:0033005,GO:0038111,GO:1904894,GO:2000664 cytokine receptor activity|extracellular region|plasma membrane|positive regulation of cell proliferation|integral component of membrane|cytokine-mediated signaling pathway|positive regulation of mast cell activation|interleukin-7-mediated signaling pathway|positive regulation of STAT cascade|positive regulation of interleukin-5 secretion hsa04060,hsa04630 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway CRLF3 618.744095320362 697.617115657 539.871074983724 0.773878769409615 -0.369820513621118 0.0285372722986785 0.6711497109187 10.3155 9.18316 7.79569 7.57799 GeneID:51379,Genbank:NM_015986.3,HGNC:HGNC:17177,MIM:614853 cytokine receptor like factor 3 GO:0000082,GO:0005737,GO:0005829,GO:0005886,GO:0030308,GO:0042802,GO:0045893,GO:0045944,GO:0046427,GO:0071158 G1/S transition of mitotic cell cycle|cytoplasm|cytosol|plasma membrane|negative regulation of cell growth|identical protein binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JAK-STAT cascade|positive regulation of cell cycle arrest CRLS1 564.890799291926 597.183938222774 532.597660361077 0.891848601866442 -0.165129272493781 0.336306966712969 1 4.28095 4.08689 4.03316 4.12343 GeneID:54675,Genbank:NM_001323562.1,HGNC:HGNC:16148,MIM:608188 cardiolipin synthase 1 GO:0003841,GO:0005739,GO:0005743,GO:0008808,GO:0016021,GO:0032049,GO:0036148,GO:0043337,GO:0047144,GO:0097068,GO:1905711 1-acylglycerol-3-phosphate O-acyltransferase activity|mitochondrion|mitochondrial inner membrane|cardiolipin synthase activity|integral component of membrane|cardiolipin biosynthetic process|phosphatidylglycerol acyl-chain remodeling|CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity|2-acylglycerol-3-phosphate O-acyltransferase activity|response to thyroxine|response to phosphatidylethanolamine hsa00564 Glycerophospholipid metabolism CRMP1 461.844595635134 459.880752783015 463.808438487252 1.00854066120504 0.0122692500751368 0.970303317909686 1 3.55466 3.89358 4.05272 3.63046 GeneID:1400,Genbank:NM_001014809.2,HGNC:HGNC:2365,MIM:602462 collapsin response mediator protein 1 GO:0000226,GO:0005813,GO:0005819,GO:0005829,GO:0006139,GO:0007399,GO:0007411,GO:0010977,GO:0016810,GO:0030496,GO:0031005,GO:1904530 microtubule cytoskeleton organization|centrosome|spindle|cytosol|nucleobase-containing compound metabolic process|nervous system development|axon guidance|negative regulation of neuron projection development|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|midbody|filamin binding|negative regulation of actin filament binding CRNDE 89.1590213038355 77.9967711495198 100.321271458151 1.28622339078415 0.363141231147751 0.247940211511712 1 0.586218 1.086 1.21105 1.04838 GeneID:643911,Genbank:NM_001308963.1,HGNC:HGNC:37078,MIM:615624 colorectal neoplasia differentially expressed CRNKL1 239.955879941667 235.172370006322 244.739389877011 1.04068088385737 0.0575277460089028 0.803763448679882 1 1.79891 1.94075 2.04237 1.82936 GeneID:51340,Genbank:NM_001278627.1,HGNC:HGNC:15762,MIM:610952 crooked neck pre-mRNA splicing factor 1 GO:0000245,GO:0000398,GO:0000974,GO:0003723,GO:0005654,GO:0005681,GO:0005737,GO:0016607,GO:0071010,GO:0071011,GO:0071012,GO:0071013,GO:0071014 spliceosomal complex assembly|mRNA splicing, via spliceosome|Prp19 complex|RNA binding|nucleoplasm|spliceosomal complex|cytoplasm|nuclear speck|prespliceosome|precatalytic spliceosome|catalytic step 1 spliceosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex hsa03040 Spliceosome CRNN 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0120446 GeneID:49860,Genbank:NM_016190.2,HGNC:HGNC:1230,MIM:611312 cornulin GO:0005509,GO:0005737,GO:0009408,GO:0016020,GO:0046914,GO:0070062,GO:0098609 calcium ion binding|cytoplasm|response to heat|membrane|transition metal ion binding|extracellular exosome|cell-cell adhesion CROCC 221.648139739357 225.688525580608 217.607753898106 0.964195026478577 -0.0526031068594823 0.796391826081294 1 1.12617 1.25493 1.28409 1.09045 GeneID:9696,Genbank:XM_006711058.3,HGNC:HGNC:21299,MIM:615776 ciliary rootlet coiled-coil, rootletin GO:0001917,GO:0003779,GO:0005198,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0007098,GO:0008104,GO:0010457,GO:0010669,GO:0015629,GO:0019894,GO:0032053,GO:0033365,GO:0035253,GO:0045494,GO:0045724,GO:0051656,GO:0070062,GO:1903566 photoreceptor inner segment|actin binding|structural molecule activity|centrosome|centriole|cytosol|plasma membrane|centrosome cycle|protein localization|centriole-centriole cohesion|epithelial structure maintenance|actin cytoskeleton|kinesin binding|ciliary basal body organization|protein localization to organelle|ciliary rootlet|photoreceptor cell maintenance|positive regulation of cilium assembly|establishment of organelle localization|extracellular exosome|positive regulation of protein localization to cilium CROT 463.295810008925 485.04586507051 441.545754947339 0.910317532308317 -0.135558228278456 0.469981026924599 1 2.31233 2.13574 2.28518 1.81256 GeneID:54677,Genbank:NM_001143935.1,HGNC:HGNC:2366,MIM:606090 carnitine O-octanoyltransferase GO:0005102,GO:0005739,GO:0005777,GO:0005782,GO:0006091,GO:0006631,GO:0006635,GO:0008458,GO:0009437,GO:0015908,GO:0015936,GO:0033540,GO:0043231,GO:0051791 receptor binding|mitochondrion|peroxisome|peroxisomal matrix|generation of precursor metabolites and energy|fatty acid metabolic process|fatty acid beta-oxidation|carnitine O-octanoyltransferase activity|carnitine metabolic process|fatty acid transport|coenzyme A metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase|intracellular membrane-bounded organelle|medium-chain fatty acid metabolic process hsa04146 Peroxisome CRTAP 12739.9090285565 12593.6730715818 12886.1449855313 1.02322371815491 0.0331216111498962 0.804501711440246 1 71.219 74.8206 76.3748 74.6051 GeneID:10491,Genbank:NM_006371.4,HGNC:HGNC:2379,MIM:605497 cartilage associated protein CRTC1 494.488969480166 482.558307442001 506.419631518331 1.04944754594075 0.0696300588622359 0.716653362134114 1 1.22733 1.35831 1.38707 1.36621 GeneID:23373,Genbank:NM_001098482.1,HGNC:HGNC:16062,MIM:607536 CREB regulated transcription coactivator 1 hsa05166 Human T-cell leukemia virus 1 infection CRTC2 806.428187626394 825.842318180451 787.014057072337 0.952983444595498 -0.0694769432992977 0.646402472427754 1 7.85851 7.97031 7.6048 7.43608 GeneID:200186,Genbank:NM_181715.2,HGNC:HGNC:27301,MIM:608972 CREB regulated transcription coactivator 2 hsa04151,hsa04152,hsa04922,hsa04931,hsa05166 PI3K-Akt signaling pathway|AMPK signaling pathway|Glucagon signaling pathway|Insulin resistance|Human T-cell leukemia virus 1 infection CRTC3 841.128809475472 799.176548720905 883.081070230038 1.10498871825434 0.144031640022492 0.36383823073769 1 4.09619 4.24643 5.29284 4.07518 GeneID:64784,Genbank:NM_022769.4,HGNC:HGNC:26148,MIM:608986 CREB regulated transcription coactivator 3 GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0008140,GO:0016032,GO:0032793,GO:0042116,GO:0043951,GO:0045944,GO:0050995,GO:0051289,GO:0097009 nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|cAMP response element binding protein binding|viral process|positive regulation of CREB transcription factor activity|macrophage activation|negative regulation of cAMP-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|negative regulation of lipid catabolic process|protein homotetramerization|energy homeostasis hsa05166 Human T-cell leukemia virus 1 infection CRY1 444.412273910583 486.564105551067 402.260442270099 0.826736780787624 -0.27450002244147 0.131892078029835 1 5.22409 4.74785 4.63168 4.00017 GeneID:1407,Genbank:XM_024448845.1,HGNC:HGNC:2384,MIM:601933 cryptochrome circadian regulator 1 hsa04710 Circadian rhythm CRY2 161.411417046454 156.099403503517 166.72343058939 1.06805937016686 0.0949918442770279 0.720390462469011 1 1.40932 1.4906 1.71061 1.45737 GeneID:1408,Genbank:NM_001127457.2,HGNC:HGNC:2385,MIM:603732 cryptochrome circadian regulator 2 hsa04710 Circadian rhythm CRYAB 682.569959408616 474.937679073892 890.202239743341 1.87435589755523 0.906394913983498 3.56820738457282e-08 3.64066403637782e-05 12.281 11.2217 21.0716 24.2823 GeneID:1410,Genbank:NM_001289807.1,HGNC:HGNC:2389,MIM:123590 crystallin alpha B hsa04141,hsa04213 Protein processing in endoplasmic reticulum|Longevity regulating pathway - multiple species CRYBA2 6.22983818708522 5.18887166768327 7.27080470648717 1.40123039692239 0.486694190007914 0.725528720407825 1 0.309278 0.266594 0.214408 0.333345 GeneID:1412,Genbank:NM_057094.1,HGNC:HGNC:2395,MIM:600836 crystallin beta A2 GO:0002088,GO:0005212,GO:0042803 lens development in camera-type eye|structural constituent of eye lens|protein homodimerization activity CRYBB1 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0 0 0 GeneID:1414,Genbank:XM_011529899.3,HGNC:HGNC:2397,MIM:600929 crystallin beta B1 CRYBB3 2.77262945425961 2.15239070656922 3.39286820195 1.57632542809016 0.656565406003474 0.790637896827523 1 0.0748911 5.17922e-07 0.074607 0.0273593 GeneID:1417,Genbank:XM_017028599.2,HGNC:HGNC:2400,MIM:123630 crystallin beta B3 GO:0005212,GO:0007601 structural constituent of eye lens|visual perception CRYBG1 1808.2205215255 1629.09906624787 1987.34197680313 1.21990247123545 0.286765811813304 0.376172477332215 1 7.21695 6.13997 10.1472 6.44481 GeneID:202,Genbank:XM_005266839.3,HGNC:HGNC:356,MIM:601797 crystallin beta-gamma domain containing 1 GO:0030246 carbohydrate binding CRYBG2 9.52112029398815 9.34957425676688 9.69266633120943 1.03669601043002 0.0519929158109863 1 1 0.0423582 0.0123698 0.0459811 0.0430643 GeneID:55057,Genbank:NM_001039775.3,HGNC:HGNC:17295 crystallin beta-gamma domain containing 2 GO:0030246 carbohydrate binding CRYBG3 108.655721098639 109.706316451839 107.605125745439 0.980847131009799 -0.027899790776651 0.981497466687708 1 0.351818 0.260737 0.367898 0.210429 GeneID:131544,Genbank:NM_153605.3,HGNC:HGNC:34427 crystallin beta-gamma domain containing 3 GO:0030246,GO:0043234,GO:0051018 carbohydrate binding|protein complex|protein kinase A binding CRYGC 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:1420,Genbank:XM_011510662.1,HGNC:HGNC:2410,MIM:123680 crystallin gamma C CRYGN 1.24081702112719 1.02816907859967 1.45346496365472 1.41364391704357 0.499418765260228 1 1 0.0199036 0.0175791 0 0.0173728 GeneID:155051,Genbank:NM_144727.2,HGNC:HGNC:20458,MIM:609603 crystallin gamma N GO:0005212 structural constituent of eye lens CRYGS 8.67259508753645 13.9523219731229 3.39286820195 0.243175882013464 -2.03992794433358 0.051175185591333 0.82804521131659 0.30161 0.233422 0.143438 0 GeneID:1427,Genbank:NM_017541.3,HGNC:HGNC:2417,MIM:123730 crystallin gamma S GO:0002009,GO:0002088,GO:0005212 morphogenesis of an epithelium|lens development in camera-type eye|structural constituent of eye lens CRYL1 212.440426520134 175.346458348801 249.534394691466 1.42309344050217 0.509030392520264 0.214223261777662 1 2.26132 2.47122 2.84401 3.80889 GeneID:51084,Genbank:NM_015974.2,HGNC:HGNC:18246,MIM:609877 crystallin lambda 1 GO:0003857,GO:0005829,GO:0006631,GO:0019640,GO:0042803,GO:0050104,GO:0070062,GO:0070403 3-hydroxyacyl-CoA dehydrogenase activity|cytosol|fatty acid metabolic process|glucuronate catabolic process to xylulose 5-phosphate|protein homodimerization activity|L-gulonate 3-dehydrogenase activity|extracellular exosome|NAD+ binding hsa00040 Pentose and glucuronate interconversions CRYZ 778.741412052257 841.637221900108 715.845602204406 0.850539381550034 -0.233550057997429 0.212154069881466 1 14.836 12.5871 12.3332 10.0664 GeneID:1429,Genbank:XM_011540747.2,HGNC:HGNC:2419,MIM:123691 crystallin zeta GO:0003730,GO:0003960,GO:0005829,GO:0007601,GO:0008270,GO:0042178,GO:0051289,GO:0070062,GO:0070402 mRNA 3'-UTR binding|NADPH:quinone reductase activity|cytosol|visual perception|zinc ion binding|xenobiotic catabolic process|protein homotetramerization|extracellular exosome|NADPH binding CRYZL1 161.803335719744 152.515016210653 171.091655228834 1.12180203287343 0.165818102514359 0.503315157415663 1 2.92858 3.01631 3.86696 2.98694 GeneID:9946,Genbank:NM_145858.2,HGNC:HGNC:2420,MIM:603920 crystallin zeta like 1 GO:0003960,GO:0005829,GO:0050661,GO:1901661 NADPH:quinone reductase activity|cytosol|NADP binding|quinone metabolic process CS 6341.67059609526 5980.36778616403 6702.97340602649 1.12082962882889 0.164566998639687 0.216360383833914 1 76.6542 81.1836 93.22 86.6973 GeneID:1431,Genbank:NM_004077.2,HGNC:HGNC:2422,MIM:118950 citrate synthase hsa00020,hsa00630 Citrate cycle (TCA cycle)|Glyoxylate and dicarboxylate metabolism CSAD 74.1026612062633 71.1455801772247 77.0597422353019 1.08312761022322 0.115203226132411 0.758143240372994 1 0.45567 0.458657 0.612509 0.500079 GeneID:51380,Genbank:XM_024449011.1,HGNC:HGNC:18966,MIM:616569 cysteine sulfinic acid decarboxylase GO:0004782,GO:0019752,GO:0030170,GO:0042412 sulfinoalanine decarboxylase activity|carboxylic acid metabolic process|pyridoxal phosphate binding|taurine biosynthetic process hsa00430 Taurine and hypotaurine metabolism CSAG1 15.953405992764 15.9126075809524 15.9942044045757 1.00512780970738 0.00737896280438849 1 1 0.200733 0.366209 0.262699 0.175028 GeneID:158511,Genbank:NM_001102576.2,HGNC:HGNC:24294,MIM:300944 chondrosarcoma associated gene 1 CSDC2 12.7364706154771 16.7486715608123 8.72426967014188 0.520893232544754 -0.94094040119968 0.242395822666043 1 0.207293 0.271812 0.172711 0.130086 GeneID:27254,Genbank:NM_014460.3,HGNC:HGNC:30359,MIM:617689 cold shock domain containing C2 GO:0003677,GO:0003723,GO:0003730,GO:0005634,GO:0005737,GO:0006355,GO:0006397,GO:0008134,GO:0043488 DNA binding|RNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|mRNA processing|transcription factor binding|regulation of mRNA stability CSDE1 13247.3552837338 13697.4967538214 12797.2138136462 0.934273907389389 -0.0980825182927869 0.466659792399251 1 105.152 99.3568 104.694 89.0669 GeneID:7812,Genbank:NM_001242893.1,HGNC:HGNC:29905,MIM:191510 cold shock domain containing E1 GO:0003677,GO:0003723,GO:0005743,GO:0005794,GO:0005829,GO:0005886,GO:0006355,GO:0008584,GO:0070937,GO:0070966 DNA binding|RNA binding|mitochondrial inner membrane|Golgi apparatus|cytosol|plasma membrane|regulation of transcription, DNA-templated|male gonad development|CRD-mediated mRNA stability complex|nuclear-transcribed mRNA catabolic process, no-go decay CSE1L 1773.09735437707 1659.38540661814 1886.80930213601 1.1370530888188 0.1852996149932 0.368501509668166 1 19.3264 15.6948 22.1431 18.2487 GeneID:1434,Genbank:NM_001316.3,HGNC:HGNC:2431,MIM:601342 chromosome segregation 1 like CSF1 2044.06121254574 1601.70817901721 2486.41424607428 1.55235159478296 0.634455353016116 0.00265078721095344 0.187026466830971 11.7675 13.0729 22.5574 16.9437 GeneID:1435,Genbank:XM_017000369.1,HGNC:HGNC:2432,MIM:120420 colony stimulating factor 1 GO:0001954,GO:0002158,GO:0003006,GO:0005125,GO:0005157,GO:0005576,GO:0005615,GO:0005788,GO:0005886,GO:0006954,GO:0007169,GO:0008083,GO:0008283,GO:0008284,GO:0010628,GO:0010743,GO:0010744,GO:0010759,GO:0016020,GO:0016021,GO:0019221,GO:0030097,GO:0030154,GO:0030225,GO:0030278,GO:0030316,GO:0030335,GO:0032270,GO:0032946,GO:0038145,GO:0040018,GO:0042117,GO:0042488,GO:0042802,GO:0042803,GO:0043687,GO:0044267,GO:0045087,GO:0045651,GO:0045657,GO:0045672,GO:0045860,GO:0046579,GO:0048471,GO:0048873,GO:0060444,GO:0060611,GO:0060763,GO:0070062,GO:1902228,GO:1904141,GO:1990682 positive regulation of cell-matrix adhesion|osteoclast proliferation|developmental process involved in reproduction|cytokine activity|macrophage colony-stimulating factor receptor binding|extracellular region|extracellular space|endoplasmic reticulum lumen|plasma membrane|inflammatory response|transmembrane receptor protein tyrosine kinase signaling pathway|growth factor activity|cell proliferation|positive regulation of cell proliferation|positive regulation of gene expression|regulation of macrophage derived foam cell differentiation|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage chemotaxis|membrane|integral component of membrane|cytokine-mediated signaling pathway|hemopoiesis|cell differentiation|macrophage differentiation|regulation of ossification|osteoclast differentiation|positive regulation of cell migration|positive regulation of cellular protein metabolic process|positive regulation of mononuclear cell proliferation|macrophage colony-stimulating factor signaling pathway|positive regulation of multicellular organism growth|monocyte activation|positive regulation of odontogenesis of dentin-containing tooth|identical protein binding|protein homodimerization activity|post-translational protein modification|cellular protein metabolic process|innate immune response|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of osteoclast differentiation|positive regulation of protein kinase activity|positive regulation of Ras protein signal transduction|perinuclear region of cytoplasm|homeostasis of number of cells within a tissue|branching involved in mammary gland duct morphogenesis|mammary gland fat development|mammary duct terminal end bud growth|extracellular exosome|positive regulation of macrophage colony-stimulating factor signaling pathway|positive regulation of microglial cell migration|CSF1-CSF1R complex hsa04010,hsa04014,hsa04015,hsa04060,hsa04151,hsa04380,hsa04640,hsa04668,hsa05323 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Osteoclast differentiation|Hematopoietic cell lineage|TNF signaling pathway|Rheumatoid arthritis CSF1R 34.1217045070498 38.1961433873504 30.0472656267492 0.786657053882045 -0.3461932704579 0.475536527852459 1 0.235672 0.241223 0.21099 0.188978 GeneID:1436,Genbank:NM_005211.3,HGNC:HGNC:2433,MIM:164770 colony stimulating factor 1 receptor hsa04010,hsa04014,hsa04015,hsa04060,hsa04151,hsa04380,hsa04640,hsa05200,hsa05202,hsa05221 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Osteoclast differentiation|Hematopoietic cell lineage|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia CSF2 14.8209550373357 21.8895169538106 7.75239312086075 0.354160082071212 -1.49752648201628 0.0462495844433653 0.79332376136203 1.02155 1.35741 0.354115 0.548072 GeneID:1437,Genbank:NM_000758.3,HGNC:HGNC:2434,MIM:138960 colony stimulating factor 2 hsa04060,hsa04630,hsa04640,hsa04650,hsa04657,hsa04660,hsa04664,hsa04668,hsa05132,hsa05146,hsa05166,hsa05167,hsa05202,hsa05221,hsa05323 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|Hematopoietic cell lineage|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Salmonella infection|Amoebiasis|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Transcriptional misregulation in cancer|Acute myeloid leukemia|Rheumatoid arthritis CSF2RA 2.6928911610804 4.90071401957362 0.48506830258717 0.0989791080748215 -3.33673214799242 0.420504865724827 1 0 0.0910927 0.0117816 0 GeneID:1438,Genbank:NM_006140.4,HGNC:HGNC:2435,MIM:425000 colony stimulating factor 2 receptor alpha subunit GO:0000165,GO:0004713,GO:0004872,GO:0004896,GO:0005088,GO:0005576,GO:0005622,GO:0005886,GO:0005887,GO:0019221,GO:0044267 MAPK cascade|protein tyrosine kinase activity|receptor activity|cytokine receptor activity|Ras guanyl-nucleotide exchange factor activity|extracellular region|intracellular|plasma membrane|integral component of plasma membrane|cytokine-mediated signaling pathway|cellular protein metabolic process hsa04060,hsa04630,hsa04640,hsa05200 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|Hematopoietic cell lineage|Pathways in cancer CSF3 0.995346334121811 0.538097676642304 1.45259499160132 2.69950058261805 1.43269252815597 0.83528100889094 1 0 0 0 0.0949944 GeneID:1440,Genbank:NM_000759.3,HGNC:HGNC:2438,MIM:138970 colony stimulating factor 3 hsa04060,hsa04151,hsa04630,hsa04640,hsa04657,hsa05144 Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Jak-STAT signaling pathway|Hematopoietic cell lineage|IL-17 signaling pathway|Malaria CSGALNACT1 19.9412077531766 18.5550696894789 21.3273458168743 1.14940801483313 0.200891014247412 0.778320695298909 1 0.0576172 0.0659884 0.0670267 0.0513683 GeneID:55790,Genbank:NM_001354476.1,HGNC:HGNC:24290,MIM:616615 chondroitin sulfate N-acetylgalactosaminyltransferase 1 hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CSGALNACT2 566.516712346397 639.635819747724 493.39760494507 0.771372693198559 -0.374500019810391 0.0727147733037536 0.93019154092086 6.38085 5.60305 5.25802 4.12727 GeneID:55454,Genbank:NM_018590.4,HGNC:HGNC:24292,MIM:616616 chondroitin sulfate N-acetylgalactosaminyltransferase 2 hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate CSK 2071.00352484891 1928.21510923038 2213.79194046743 1.14810423892542 0.199253633436654 0.165266588552675 1 24.5864 26.5313 30.8797 29.5753 GeneID:1445,Genbank:NM_004383.2,HGNC:HGNC:2444,MIM:124095 C-terminal Src kinase hsa05120 Epithelial cell signaling in Helicobacter pylori infection CSKMT 48.3286565199221 44.8072029862208 51.8501100536234 1.15718247509376 0.210616379705091 0.644421059739968 1 0.922539 1.32905 1.33784 1.63384 GeneID:751071,Genbank:XM_005274232.5,HGNC:HGNC:33113,MIM:617897 citrate synthase lysine methyltransferase GO:0005739,GO:0006479,GO:0016278,GO:0016279,GO:0018023,GO:0018026,GO:0018027 mitochondrion|protein methylation|lysine N-methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation CSMD1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:64478,Genbank:XM_011534752.2,HGNC:HGNC:14026,MIM:608397 CUB and Sushi multiple domains 1 GO:0016021 integral component of membrane CSMD2 276.930269152382 256.735511692446 297.125026612319 1.15731954903168 0.210787263885487 0.502735964324403 1 0.361865 0.439615 0.564903 0.366333 GeneID:114784,Genbank:NM_052896.4,HGNC:HGNC:19290,MIM:608398 CUB and Sushi multiple domains 2 GO:0005886,GO:0016021 plasma membrane|integral component of membrane CSMD3 4.77300170169201 4.69880026572591 4.84720313765811 1.03158314112959 0.0448601008769565 1 1 0.0138177 0.0052731 0.0133365 0.0074192 GeneID:114788,Genbank:NM_052900.2,HGNC:HGNC:19291,MIM:608399 CUB and Sushi multiple domains 3 GO:0005886,GO:0016021,GO:0050773 plasma membrane|integral component of membrane|regulation of dendrite development CSNK1A1 3785.33565177581 3797.09706785432 3773.57423569729 0.993805048505034 -0.00896522412564664 0.958429805295403 1 42.1028 42.1855 47.5744 39.3437 GeneID:1452,Genbank:NM_001271741.1,HGNC:HGNC:2451,MIM:600505 casein kinase 1 alpha 1 GO:0000139,GO:0000777,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0006468,GO:0006909,GO:0007049,GO:0008360,GO:0016055,GO:0016607,GO:0018105,GO:0036064,GO:0045104,GO:0051301 Golgi membrane|condensed chromosome kinetochore|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|protein phosphorylation|phagocytosis|cell cycle|regulation of cell shape|Wnt signaling pathway|nuclear speck|peptidyl-serine phosphorylation|ciliary basal body|intermediate filament cytoskeleton organization|cell division hsa04310,hsa04340,hsa05165,hsa05224,hsa05225,hsa05226 Wnt signaling pathway|Hedgehog signaling pathway|Human papillomavirus infection|Breast cancer|Hepatocellular carcinoma|Gastric cancer CSNK1A1L 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0163847 0 0 0 GeneID:122011,Genbank:NM_145203.5,HGNC:HGNC:20289 casein kinase 1 alpha 1 like GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006909,GO:0008360,GO:0016055,GO:0018105 protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|phagocytosis|regulation of cell shape|Wnt signaling pathway|peptidyl-serine phosphorylation hsa04310,hsa04340,hsa05165,hsa05224,hsa05225,hsa05226 Wnt signaling pathway|Hedgehog signaling pathway|Human papillomavirus infection|Breast cancer|Hepatocellular carcinoma|Gastric cancer CSNK1D 4898.26283761651 4980.03570792571 4816.48996730731 0.967159725309173 -0.0481739260928242 0.704688990775247 1 29.6703 30.482 28.9862 31.0066 GeneID:1453,Genbank:XM_005256337.5,HGNC:HGNC:2452,MIM:600864 casein kinase 1 delta GO:0000086,GO:0000139,GO:0001934,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005794,GO:0005813,GO:0005819,GO:0005829,GO:0005876,GO:0005886,GO:0006364,GO:0006468,GO:0006897,GO:0007020,GO:0007030,GO:0008360,GO:0010389,GO:0016055,GO:0018105,GO:0032436,GO:0032922,GO:0033116,GO:0034067,GO:0042277,GO:0042752,GO:0043005,GO:0045296,GO:0048208,GO:0048471,GO:0050321,GO:0051225,GO:0061512,GO:0071539,GO:0090263,GO:0097711,GO:1905426,GO:1905515,GO:1990090,GO:2000052 G2/M transition of mitotic cell cycle|Golgi membrane|positive regulation of protein phosphorylation|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|Golgi apparatus|centrosome|spindle|cytosol|spindle microtubule|plasma membrane|rRNA processing|protein phosphorylation|endocytosis|microtubule nucleation|Golgi organization|regulation of cell shape|regulation of G2/M transition of mitotic cell cycle|Wnt signaling pathway|peptidyl-serine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|circadian regulation of gene expression|endoplasmic reticulum-Golgi intermediate compartment membrane|protein localization to Golgi apparatus|peptide binding|regulation of circadian rhythm|neuron projection|cadherin binding|COPII vesicle coating|perinuclear region of cytoplasm|tau-protein kinase activity|spindle assembly|protein localization to cilium|protein localization to centrosome|positive regulation of canonical Wnt signaling pathway|ciliary basal body-plasma membrane docking|positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation|non-motile cilium assembly|cellular response to nerve growth factor stimulus|positive regulation of non-canonical Wnt signaling pathway hsa04340,hsa04390,hsa04540,hsa04710 Hedgehog signaling pathway|Hippo signaling pathway|Gap junction|Circadian rhythm CSNK1E 2.93638115004879 1.02816907859967 4.84459322149792 4.71186434442874 2.23629800427084 0.285753015024831 1 25.0608 24.8225 24.5647 25.8527 GeneID:1454,Genbank:NM_001894.4,HGNC:HGNC:2453,MIM:600863 casein kinase 1 epsilon GO:0000086,GO:0003723,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006364,GO:0006468,GO:0006897,GO:0007165,GO:0008360,GO:0010389,GO:0016055,GO:0018105,GO:0032091,GO:0032436,GO:0032922,GO:0042752,GO:0097711,GO:1903827,GO:1905426,GO:2000052 G2/M transition of mitotic cell cycle|RNA binding|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|rRNA processing|protein phosphorylation|endocytosis|signal transduction|regulation of cell shape|regulation of G2/M transition of mitotic cell cycle|Wnt signaling pathway|peptidyl-serine phosphorylation|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|circadian regulation of gene expression|regulation of circadian rhythm|ciliary basal body-plasma membrane docking|regulation of cellular protein localization|positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation|positive regulation of non-canonical Wnt signaling pathway hsa04068,hsa04310,hsa04340,hsa04390,hsa04392,hsa04710 FoxO signaling pathway|Wnt signaling pathway|Hedgehog signaling pathway|Hippo signaling pathway|Hippo signaling pathway - multiple species|Circadian rhythm CSNK1G1 637.723748784302 673.008701355509 602.438796213096 0.895142655659164 -0.159810477078434 0.345195108442419 1 3.17013 2.91397 3.03833 2.44253 GeneID:53944,Genbank:NM_001329606.1,HGNC:HGNC:2454,MIM:606274 casein kinase 1 gamma 1 GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006897,GO:0008360,GO:0016055,GO:0018105 protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|endocytosis|regulation of cell shape|Wnt signaling pathway|peptidyl-serine phosphorylation hsa04340 Hedgehog signaling pathway CSNK1G2 3063.6232287386 2947.24531898138 3180.00113849583 1.0789740229683 0.109660131382047 0.425590834391509 1 22.8051 22.6211 24.852 25.8696 GeneID:1455,Genbank:XM_005259498.1,HGNC:HGNC:2455,MIM:602214 casein kinase 1 gamma 2 GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0006897,GO:0007165,GO:0008360,GO:0016020,GO:0016055,GO:0018105,GO:0030148,GO:0042277,GO:0046777,GO:0051219 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|endocytosis|signal transduction|regulation of cell shape|membrane|Wnt signaling pathway|peptidyl-serine phosphorylation|sphingolipid biosynthetic process|peptide binding|protein autophosphorylation|phosphoprotein binding hsa04340 Hedgehog signaling pathway CSNK1G3 323.35968505932 345.253088000532 301.466282118108 0.873174759606042 -0.195657667166871 0.335902469944161 1 2.44805 2.18218 2.18218 1.72234 GeneID:1456,Genbank:NM_001031812.3,HGNC:HGNC:2456,MIM:604253 casein kinase 1 gamma 3 GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006897,GO:0008360,GO:0016055,GO:0018105 protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|endocytosis|regulation of cell shape|Wnt signaling pathway|peptidyl-serine phosphorylation hsa04340 Hedgehog signaling pathway CSNK2A1 2170.71524097159 2249.78005680183 2091.65042514134 0.929713293002835 -0.105142211499615 0.451789734741681 1 14.8165 15.5519 14.6377 14.4052 GeneID:1457,Genbank:XM_024451837.1,HGNC:HGNC:2457,MIM:115440 casein kinase 2 alpha 1 GO:0004674,GO:0005524,GO:0005634,GO:0006351,GO:0006355,GO:0006468,GO:0006915,GO:0007049,GO:0008284,GO:0016055,GO:0030177,GO:0030307,GO:0043154,GO:0045732,GO:0047485,GO:0048511,GO:1905818 protein serine/threonine kinase activity|ATP binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|cell cycle|positive regulation of cell proliferation|Wnt signaling pathway|positive regulation of Wnt signaling pathway|positive regulation of cell growth|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein catabolic process|protein N-terminus binding|rhythmic process|regulation of chromosome separation hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05162,hsa05168 Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Measles|Herpes simplex infection CSNK2A2 936.000203379361 900.291902655828 971.708504102893 1.07932605106898 0.110130751019898 0.4666024664932 1 8.50898 7.79084 8.91825 8.31063 GeneID:1459,Genbank:NM_001896.3,HGNC:HGNC:2459,MIM:115442 casein kinase 2 alpha 2 GO:0000785,GO:0001669,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006351,GO:0006355,GO:0006457,GO:0006656,GO:0006915,GO:0007049,GO:0007283,GO:0016055,GO:0016236,GO:0021987,GO:0047485,GO:0097421,GO:1901796,GO:1903146,GO:1903955,GO:1905818 chromatin|acrosomal vesicle|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|protein folding|phosphatidylcholine biosynthetic process|apoptotic process|cell cycle|spermatogenesis|Wnt signaling pathway|macroautophagy|cerebral cortex development|protein N-terminus binding|liver regeneration|regulation of signal transduction by p53 class mediator|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|regulation of chromosome separation hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05162,hsa05168 Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Measles|Herpes simplex infection CSNK2A3 149.78049754672 147.864242219612 151.696752873828 1.02591911740584 0.0369169945734324 0.893990894257315 1 5.74902 5.42407 5.98481 5.18115 GeneID:283106,Genbank:NM_001256686.1,HGNC:HGNC:2458 casein kinase 2 alpha 3 GO:0004674,GO:0005524,GO:0005654,GO:0006468,GO:0008013,GO:0008284,GO:0019888,GO:0030307,GO:0045732,GO:0046777 protein serine/threonine kinase activity|ATP binding|nucleoplasm|protein phosphorylation|beta-catenin binding|positive regulation of cell proliferation|protein phosphatase regulator activity|positive regulation of cell growth|positive regulation of protein catabolic process|protein autophosphorylation hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05162,hsa05168 Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Measles|Herpes simplex infection CSNK2B 3911.20249820095 3940.17931691651 3882.22567948539 0.985291624372955 -0.0213773015184484 0.867120416476863 1 136.783 137.235 135.142 138.016 GeneID:1460,Genbank:NM_001320.6,HGNC:HGNC:2460,MIM:115441 casein kinase 2 beta GO:0005956,GO:0016055,GO:0019887,GO:0046872 protein kinase CK2 complex|Wnt signaling pathway|protein kinase regulator activity|metal ion binding hsa03008,hsa04064,hsa04137,hsa04310,hsa04520,hsa05162,hsa05168 Ribosome biogenesis in eukaryotes|NF-kappa B signaling pathway|Mitophagy - animal|Wnt signaling pathway|Adherens junction|Measles|Herpes simplex infection CSPG4 16.4901128457048 20.8613478752109 12.1188778161987 0.580924966531011 -0.78357626069686 0.264278799465558 1 0.085751 0.11724 0.0843529 0.0395139 GeneID:1464,Genbank:NM_001897.4,HGNC:HGNC:2466,MIM:601172 chondroitin sulfate proteoglycan 4 GO:0000187,GO:0001525,GO:0004871,GO:0005576,GO:0005796,GO:0005887,GO:0005925,GO:0007169,GO:0008283,GO:0008347,GO:0009986,GO:0016324,GO:0019901,GO:0030203,GO:0030206,GO:0030207,GO:0030208,GO:0031012,GO:0031258,GO:0035556,GO:0043202,GO:0048771,GO:0050731,GO:0070062 activation of MAPK activity|angiogenesis|signal transducer activity|extracellular region|Golgi lumen|integral component of plasma membrane|focal adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|cell proliferation|glial cell migration|cell surface|apical plasma membrane|protein kinase binding|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|extracellular matrix|lamellipodium membrane|intracellular signal transduction|lysosomal lumen|tissue remodeling|positive regulation of peptidyl-tyrosine phosphorylation|extracellular exosome CSPG5 95.5054789050583 87.3081277867097 103.702830023407 1.18777979384404 0.248267395249659 0.433236938162363 1 1.04861 1.18827 1.41952 1.57503 GeneID:10675,Genbank:NM_001206942.1,HGNC:HGNC:2467,MIM:606775 chondroitin sulfate proteoglycan 5 GO:0000139,GO:0005576,GO:0005789,GO:0005794,GO:0005796,GO:0005887,GO:0007399,GO:0008083,GO:0009986,GO:0016020,GO:0016021,GO:0030154,GO:0030203,GO:0030206,GO:0030207,GO:0030208,GO:0030660,GO:0040008,GO:0043202,GO:0046907,GO:0050804 Golgi membrane|extracellular region|endoplasmic reticulum membrane|Golgi apparatus|Golgi lumen|integral component of plasma membrane|nervous system development|growth factor activity|cell surface|membrane|integral component of membrane|cell differentiation|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|Golgi-associated vesicle membrane|regulation of growth|lysosomal lumen|intracellular transport|modulation of chemical synaptic transmission CSPP1 104.737725287015 122.726521895732 86.7489286782977 0.706847446976452 -0.500529211166219 0.161990320462121 1 0.491873 0.350034 0.317693 0.312141 GeneID:79848,Genbank:XM_011517598.2,HGNC:HGNC:26193,MIM:611654 centrosome and spindle pole associated protein 1 GO:0000922,GO:0005737,GO:0005813,GO:0005819,GO:0005874,GO:0032467,GO:0051781 spindle pole|cytoplasm|centrosome|spindle|microtubule|positive regulation of cytokinesis|positive regulation of cell division CSRNP1 388.74493312231 377.655635459511 399.83423078511 1.05872703395148 0.0823306747629828 0.669074700172412 1 4.0317 3.86317 4.589 4.06844 GeneID:64651,Genbank:NM_001320560.1,HGNC:HGNC:14300,MIM:606458 cysteine and serine rich nuclear protein 1 GO:0001228,GO:0003700,GO:0005634,GO:0006915,GO:0009791,GO:0043565,GO:0045944,GO:0048008,GO:0048705,GO:0060021,GO:0060325 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|apoptotic process|post-embryonic development|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|palate development|face morphogenesis CSRNP2 677.848799914069 694.639486626534 661.058113201604 0.951656400087454 -0.0714873190098975 0.660684965909432 1 4.6018 4.72104 4.77477 4.23149 GeneID:81566,Genbank:NM_030809.2,HGNC:HGNC:16006 cysteine and serine rich nuclear protein 2 GO:0001228,GO:0003700,GO:0005634,GO:0006915,GO:0010923,GO:0019902,GO:0043565,GO:0045944 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|apoptotic process|negative regulation of phosphatase activity|phosphatase binding|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter CSRNP3 18.9329186846026 15.5666150030498 22.2992223661555 1.43250297908611 0.518538139267202 0.429057705774602 1 0.0580324 0.0365021 0.0892106 0.0307928 GeneID:80034,Genbank:NM_001172173.1,HGNC:HGNC:30729 cysteine and serine rich nuclear protein 3 GO:0001228,GO:0003700,GO:0005634,GO:0006915,GO:0010923,GO:0043065,GO:0043565,GO:0045944 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|apoptotic process|negative regulation of phosphatase activity|positive regulation of apoptotic process|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter CSRP1 5708.2201387005 5009.09705046781 6407.34322693319 1.27914136268028 0.355175710637167 0.0308261767788744 0.695369080690778 74.3166 84.8439 98.8471 109.493 GeneID:1465,Genbank:NM_001193570.1,HGNC:HGNC:2469,MIM:123876 cysteine and glycine rich protein 1 GO:0003723,GO:0005634,GO:0005925,GO:0008270,GO:0070062,GO:0070527 RNA binding|nucleus|focal adhesion|zinc ion binding|extracellular exosome|platelet aggregation CSRP2 1321.09396153597 1238.28219752297 1403.90572554896 1.13375265214771 0.181105925603517 0.220992249405626 1 52.6123 54.4373 57.1098 60.1747 GeneID:1466,Genbank:NM_001300965.1,HGNC:HGNC:2470,MIM:601871 cysteine and glycine rich protein 2 GO:0005634,GO:0005925,GO:0007275,GO:0030154,GO:0046872 nucleus|focal adhesion|multicellular organism development|cell differentiation|metal ion binding CSRP3 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0298179 0 0.0283455 GeneID:8048,Genbank:NM_003476.4,HGNC:HGNC:2472,MIM:600824 cysteine and glycine rich protein 3 GO:0002026,GO:0003300,GO:0003779,GO:0005634,GO:0005856,GO:0006351,GO:0006874,GO:0007519,GO:0008307,GO:0030018,GO:0031433,GO:0033365,GO:0035995,GO:0042802,GO:0042805,GO:0045662,GO:0045663,GO:0045944,GO:0046872,GO:0048738,GO:0055003,GO:0060048,GO:1903919,GO:1903920 regulation of the force of heart contraction|cardiac muscle hypertrophy|actin binding|nucleus|cytoskeleton|transcription, DNA-templated|cellular calcium ion homeostasis|skeletal muscle tissue development|structural constituent of muscle|Z disc|telethonin binding|protein localization to organelle|detection of muscle stretch|identical protein binding|actinin binding|negative regulation of myoblast differentiation|positive regulation of myoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|cardiac muscle tissue development|cardiac myofibril assembly|cardiac muscle contraction|negative regulation of actin filament severing|positive regulation of actin filament severing CST3 1868.38416756673 1757.61547742199 1979.15285771147 1.12604428166189 0.171263562478407 0.238765661894153 1 24.8063 26.862 29.2139 30.0061 GeneID:1471,Genbank:NM_001288614.1,HGNC:HGNC:2475,MIM:604312 cystatin C GO:0001540,GO:0001654,GO:0001666,GO:0002020,GO:0004866,GO:0004869,GO:0005576,GO:0005604,GO:0005615,GO:0005764,GO:0005771,GO:0005788,GO:0006915,GO:0006952,GO:0007420,GO:0007431,GO:0007566,GO:0008284,GO:0009743,GO:0010466,GO:0010711,GO:0010716,GO:0030424,GO:0031667,GO:0031965,GO:0032355,GO:0034103,GO:0042747,GO:0042802,GO:0043025,GO:0043067,GO:0043292,GO:0043312,GO:0043687,GO:0044267,GO:0045740,GO:0045861,GO:0048471,GO:0048678,GO:0060009,GO:0060311,GO:0060313,GO:0060548,GO:0070062,GO:0070301,GO:0097435,GO:1904724,GO:1904813,GO:2000117 amyloid-beta binding|eye development|response to hypoxia|protease binding|endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|extracellular region|basement membrane|extracellular space|lysosome|multivesicular body|endoplasmic reticulum lumen|apoptotic process|defense response|brain development|salivary gland development|embryo implantation|positive regulation of cell proliferation|response to carbohydrate|negative regulation of peptidase activity|negative regulation of collagen catabolic process|negative regulation of extracellular matrix disassembly|axon|response to nutrient levels|nuclear membrane|response to estradiol|regulation of tissue remodeling|circadian sleep/wake cycle, REM sleep|identical protein binding|neuronal cell body|regulation of programmed cell death|contractile fiber|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|positive regulation of DNA replication|negative regulation of proteolysis|perinuclear region of cytoplasm|response to axon injury|Sertoli cell development|negative regulation of elastin catabolic process|negative regulation of blood vessel remodeling|negative regulation of cell death|extracellular exosome|cellular response to hydrogen peroxide|supramolecular fiber organization|tertiary granule lumen|ficolin-1-rich granule lumen|negative regulation of cysteine-type endopeptidase activity hsa04970 Salivary secretion CST7 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0502161 0 0 0 GeneID:8530,Genbank:NM_003650.3,HGNC:HGNC:2479,MIM:603253 cystatin F GO:0002020,GO:0004866,GO:0004869,GO:0005615,GO:0005737,GO:0006955,GO:2000117 protease binding|endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|extracellular space|cytoplasm|immune response|negative regulation of cysteine-type endopeptidase activity CSTA 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.12863 0.0628544 0 0 GeneID:1475,Genbank:NM_005213.3,HGNC:HGNC:2481,MIM:184600 cystatin A CSTB 1719.58192093359 1742.99856225668 1696.1652796105 0.973130624625678 -0.0392946219970394 0.777625323288757 1 90.8634 92.8913 90.984 89.2525 GeneID:1476,Genbank:NM_000100.3,HGNC:HGNC:2482,MIM:601145 cystatin B CSTF1 900.088848464172 913.29350779036 886.884189137983 0.971083426711012 -0.0423328506002433 0.789959531115988 1 12.982 13.4099 13.2053 12.3497 GeneID:1477,Genbank:NM_001033521.1,HGNC:HGNC:2483,MIM:600369 cleavage stimulation factor subunit 1 GO:0000398,GO:0003723,GO:0005654,GO:0006369,GO:0031124 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|termination of RNA polymerase II transcription|mRNA 3'-end processing hsa03015 mRNA surveillance pathway CSTF2 1025.94996237505 1065.21259139458 986.687333355518 0.926282078644738 -0.110476493743868 0.473674890590701 1 13.5057 12.7155 12.3598 11.8796 GeneID:1478,Genbank:NM_001325.2,HGNC:HGNC:2484,MIM:300907 cleavage stimulation factor subunit 2 GO:0000398,GO:0003723,GO:0003729,GO:0005654,GO:0005847,GO:0006369,GO:0006378,GO:0006388,GO:0016604,GO:0031124,GO:0071920,GO:0098789 mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|tRNA splicing, via endonucleolytic cleavage and ligation|nuclear body|mRNA 3'-end processing|cleavage body|pre-mRNA cleavage required for polyadenylation hsa03015 mRNA surveillance pathway CSTF2T 811.519525008697 847.16329449144 775.875755525953 0.915851478187235 -0.1268144365824 0.43540349258672 1 8.38861 8.05172 7.6117 7.54622 GeneID:23283,Genbank:NM_015235.2,HGNC:HGNC:17086,MIM:611968 cleavage stimulation factor subunit 2 tau variant GO:0000398,GO:0003723,GO:0003729,GO:0005622,GO:0005654,GO:0005847,GO:0006369,GO:0031124,GO:0098789 mRNA splicing, via spliceosome|RNA binding|mRNA binding|intracellular|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA 3'-end processing|pre-mRNA cleavage required for polyadenylation hsa03015 mRNA surveillance pathway CSTF3 845.696228473053 890.298369517941 801.094087428166 0.899804059915244 -0.152317218516775 0.342363905434787 1 8.39761 8.0161 7.60512 7.1954 GeneID:1479,Genbank:NM_001326.2,HGNC:HGNC:2485,MIM:600367 cleavage stimulation factor subunit 3 GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0006369,GO:0006378,GO:0006379,GO:0031124 mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|mRNA 3'-end processing hsa03015 mRNA surveillance pathway CT45A1 78.661937855083 76.3922867747008 80.9315889354652 1.05942094879489 0.0832759416162541 0.84416089698526 1 1.98413 2.39265 2.52943 2.07186 GeneID:541466,Genbank:XM_011531352.1,HGNC:HGNC:33267,MIM:300648 cancer/testis antigen family 45 member A1 CT45A10 5.48072414554709 5.6309167949557 5.33053149613849 0.946654282107969 -0.0790904448555894 1 1 0.0280518 0.158322 0 0.0499101 GeneID:102723631,Genbank:NM_001291529.1,HGNC:HGNC:51263 cancer/testis antigen family 45 member A10 CT45A5 3.45590377474552 3.03648096111406 3.87532658837698 1.27625584945382 0.351917573411544 0.934010490353218 1 0 0 0 0.0279218 GeneID:441521,Genbank:NM_001007551.4,HGNC:HGNC:33270,MIM:300796 cancer/testis antigen family 45 member A5 CT45A9 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:102723680,Genbank:NM_001321271.1,HGNC:HGNC:51262 cancer/testis antigen family 45 member A9 CT55 2.53846992407471 3.6226049124413 1.45433493570811 0.401461095222781 -1.31666790900949 0.585722043824866 1 0.0666867 0.0617174 0.0422845 0.0197333 GeneID:54967,Genbank:NM_001031705.2,HGNC:HGNC:26047 cancer/testis antigen 55 CT62 0.998282869833606 1.02816907859967 0.968396661067546 0.941865186596032 -0.0864075197076174 1 1 0 0 0 0 GeneID:196993,Genbank:XM_006720429.3,HGNC:HGNC:27286 cancer/testis antigen 62 CT83 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:203413,Genbank:NM_001017978.3,HGNC:HGNC:33494,MIM:300625 cancer/testis antigen 83 GO:0005634,GO:0005886,GO:0016021 nucleus|plasma membrane|integral component of membrane CTAGE1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00984027 0 0 0 GeneID:64693,Genbank:NM_172241.2,HGNC:HGNC:24346,MIM:608856 cutaneous T cell lymphoma-associated antigen 1 GO:0016021 integral component of membrane CTBP1 5956.25020004911 5772.29545609113 6140.20494400709 1.06373711995766 0.089141663440542 0.515603799806042 1 14.8254 15.7034 17.3178 16.4659 GeneID:1487,Genbank:NM_001328.2,HGNC:HGNC:2494,MIM:602618 C-terminal binding protein 1 GO:0000122,GO:0001106,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006351,GO:0006468,GO:0008022,GO:0008134,GO:0008285,GO:0016618,GO:0017053,GO:0019079,GO:0019904,GO:0030267,GO:0031065,GO:0035067,GO:0042802,GO:0042803,GO:0045892,GO:0050872,GO:0051287,GO:0051726,GO:0070491,GO:0090241,GO:1903758 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription corepressor activity|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|cytosol|transcription, DNA-templated|protein phosphorylation|protein C-terminus binding|transcription factor binding|negative regulation of cell proliferation|hydroxypyruvate reductase activity|transcriptional repressor complex|viral genome replication|protein domain specific binding|glyoxylate reductase (NADP) activity|positive regulation of histone deacetylation|negative regulation of histone acetylation|identical protein binding|protein homodimerization activity|negative regulation of transcription, DNA-templated|white fat cell differentiation|NAD binding|regulation of cell cycle|repressing transcription factor binding|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter by histone modification hsa04310,hsa04330,hsa05200,hsa05220 Wnt signaling pathway|Notch signaling pathway|Pathways in cancer|Chronic myeloid leukemia CTBP2 1862.56648646326 1951.40809325323 1773.7248796733 0.908946153193557 -0.137733264518177 0.336683174965718 1 7.90583 7.49071 7.14674 7.01908 GeneID:1488,Genbank:NM_001083914.2,HGNC:HGNC:2495,MIM:602619 C-terminal binding protein 2 GO:0003682,GO:0003713,GO:0003714,GO:0005634,GO:0005829,GO:0006351,GO:0008285,GO:0016618,GO:0017053,GO:0019079,GO:0019901,GO:0030054,GO:0030267,GO:0032403,GO:0035563,GO:0042803,GO:0042974,GO:0045892,GO:0045944,GO:0048386,GO:0050872,GO:0051287,GO:0097470,GO:1990830 chromatin binding|transcription coactivator activity|transcription corepressor activity|nucleus|cytosol|transcription, DNA-templated|negative regulation of cell proliferation|hydroxypyruvate reductase activity|transcriptional repressor complex|viral genome replication|protein kinase binding|cell junction|glyoxylate reductase (NADP) activity|protein complex binding|positive regulation of chromatin binding|protein homodimerization activity|retinoic acid receptor binding|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of retinoic acid receptor signaling pathway|white fat cell differentiation|NAD binding|ribbon synapse|cellular response to leukemia inhibitory factor hsa04310,hsa04330,hsa05200,hsa05220 Wnt signaling pathway|Notch signaling pathway|Pathways in cancer|Chronic myeloid leukemia CTBS 325.106493901737 292.067661907206 358.145325896268 1.22624094553151 0.294242483735016 0.13449534392285 1 4.09425 4.68707 5.2572 5.24814 GeneID:1486,Genbank:NM_004388.2,HGNC:HGNC:2496,MIM:600873 chitobiase GO:0004568,GO:0005615,GO:0005764,GO:0006032,GO:0008061,GO:0009313,GO:0070062 chitinase activity|extracellular space|lysosome|chitin catabolic process|chitin binding|oligosaccharide catabolic process|extracellular exosome CTC1 638.495113532193 619.352821170441 657.637405893946 1.06181385377587 0.0865308699340132 0.617195130434035 1 3.13058 3.18317 3.52615 3.48531 GeneID:80169,Genbank:NM_025099.5,HGNC:HGNC:26169,MIM:613129 CST telomere replication complex component 1 GO:0000723,GO:0000784,GO:0003697,GO:0005634,GO:0006974,GO:0010389,GO:0010833,GO:0016233,GO:0032211,GO:0035264,GO:0042162,GO:0045740,GO:0048146,GO:0048536,GO:0048538,GO:0048539,GO:0071425,GO:0090399,GO:0098505,GO:1990879 telomere maintenance|nuclear chromosome, telomeric region|single-stranded DNA binding|nucleus|cellular response to DNA damage stimulus|regulation of G2/M transition of mitotic cell cycle|telomere maintenance via telomere lengthening|telomere capping|negative regulation of telomere maintenance via telomerase|multicellular organism growth|telomeric DNA binding|positive regulation of DNA replication|positive regulation of fibroblast proliferation|spleen development|thymus development|bone marrow development|hematopoietic stem cell proliferation|replicative senescence|G-rich strand telomeric DNA binding|CST complex CTCF 2009.89545353621 2016.30720671885 2003.48370035358 0.99364010289576 -0.00920469359014454 0.963994010428781 1 15.5249 14.7354 15.923 14.7478 GeneID:10664,Genbank:NM_006565.3,HGNC:HGNC:13723,MIM:604167 CCCTC-binding factor CTCFL 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0052682 GeneID:140690,Genbank:NM_001269043.1,HGNC:HGNC:16234,MIM:607022 CCCTC-binding factor like GO:0000978,GO:0001077,GO:0003677,GO:0005634,GO:0005737,GO:0006349,GO:0007049,GO:0010628,GO:0016571,GO:0042393,GO:0043046,GO:0043565,GO:0044212,GO:0045893,GO:0045944,GO:0046872,GO:0051569 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|nucleus|cytoplasm|regulation of gene expression by genetic imprinting|cell cycle|positive regulation of gene expression|histone methylation|histone binding|DNA methylation involved in gamete generation|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|regulation of histone H3-K4 methylation CTDNEP1 4120.09075326497 3959.94790313079 4280.23360339915 1.08088129139657 0.112208086701119 0.418934716138539 1 83.2929 87.4207 96.6704 92.8392 GeneID:23399,Genbank:NM_015343.4,HGNC:HGNC:19085,MIM:610684 CTD nuclear envelope phosphatase 1 GO:0004722,GO:0005635,GO:0005737,GO:0005789,GO:0005811,GO:0006470,GO:0006998,GO:0007077,GO:0007276,GO:0007498,GO:0010867,GO:0016021,GO:0031965,GO:0034504,GO:0071595,GO:0090263 protein serine/threonine phosphatase activity|nuclear envelope|cytoplasm|endoplasmic reticulum membrane|lipid droplet|protein dephosphorylation|nuclear envelope organization|mitotic nuclear envelope disassembly|gamete generation|mesoderm development|positive regulation of triglyceride biosynthetic process|integral component of membrane|nuclear membrane|protein localization to nucleus|Nem1-Spo7 phosphatase complex|positive regulation of canonical Wnt signaling pathway CTDP1 357.808158698857 342.477372723914 373.138944673801 1.08952875253048 0.123704269501811 0.559832185106183 1 3.09693 3.61971 3.46822 3.92885 GeneID:9150,Genbank:NM_004715.4,HGNC:HGNC:2498,MIM:604927 CTD phosphatase subunit 1 GO:0000922,GO:0001096,GO:0004721,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005819,GO:0006366,GO:0006368,GO:0006470,GO:0008420,GO:0010458,GO:0016591,GO:0030496,GO:0030957,GO:0043231,GO:0043234,GO:0043923,GO:0050434,GO:0051233,GO:0051301,GO:0061052,GO:0070940 spindle pole|TFIIF-class transcription factor binding|phosphoprotein phosphatase activity|nucleus|nucleoplasm|cytoplasm|centrosome|spindle|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|protein dephosphorylation|CTD phosphatase activity|exit from mitosis|DNA-directed RNA polymerase II, holoenzyme|midbody|Tat protein binding|intracellular membrane-bounded organelle|protein complex|positive regulation by host of viral transcription|positive regulation of viral transcription|spindle midzone|cell division|negative regulation of cell growth involved in cardiac muscle cell development|dephosphorylation of RNA polymerase II C-terminal domain CTDSP1 1259.24136247852 1213.88550563044 1304.5972193266 1.0747283934732 0.103972106420396 0.497724019458334 1 9.95308 10.6734 11.6914 11.6747 GeneID:58190,Genbank:NM_001206878.1,HGNC:HGNC:21614,MIM:605323 CTD small phosphatase 1 GO:0001933,GO:0005634,GO:0005654,GO:0006357,GO:0006470,GO:0008420,GO:0045665,GO:0046872,GO:0070062,GO:2000134 negative regulation of protein phosphorylation|nucleus|nucleoplasm|regulation of transcription from RNA polymerase II promoter|protein dephosphorylation|CTD phosphatase activity|negative regulation of neuron differentiation|metal ion binding|extracellular exosome|negative regulation of G1/S transition of mitotic cell cycle CTDSP2 2252.07127652481 2408.25439907684 2095.88815397277 0.870293501706545 -0.200426070882096 0.144877580438305 1 12.0749 12.9282 10.3919 11.4099 GeneID:10106,Genbank:XM_005268556.2,HGNC:HGNC:17077,MIM:608711 CTD small phosphatase 2 GO:0001933,GO:0005654,GO:0006470,GO:0008420,GO:0036498,GO:0046872,GO:2000134 negative regulation of protein phosphorylation|nucleoplasm|protein dephosphorylation|CTD phosphatase activity|IRE1-mediated unfolded protein response|metal ion binding|negative regulation of G1/S transition of mitotic cell cycle CTDSPL 964.446970318065 967.364041139086 961.529899497043 0.993969031932205 -0.00872719096077802 0.953471876516683 1 6.76918 7.07092 7.18829 6.42196 GeneID:10217,Genbank:XM_017005519.1,HGNC:HGNC:16890,MIM:608592 CTD small phosphatase like GO:0001933,GO:0004721,GO:0005634,GO:0046872,GO:0070062,GO:2000134 negative regulation of protein phosphorylation|phosphoprotein phosphatase activity|nucleus|metal ion binding|extracellular exosome|negative regulation of G1/S transition of mitotic cell cycle CTDSPL2 563.978641717609 621.454134599761 506.503148835457 0.815029011210398 -0.295076681452293 0.480872664097918 1 4.65927 3.06787 3.69336 2.68347 GeneID:51496,Genbank:XM_011521665.2,HGNC:HGNC:26936 CTD small phosphatase like 2 GO:0004721,GO:0005654,GO:0030514,GO:0046827 phosphoprotein phosphatase activity|nucleoplasm|negative regulation of BMP signaling pathway|positive regulation of protein export from nucleus CTF1 1.70731027176878 1.96028560782945 1.45433493570811 0.741899511938183 -0.430704303521243 0.968964006615108 1 0 0.079957 0 0 GeneID:1489,Genbank:XM_011545759.2,HGNC:HGNC:2499,MIM:600435 cardiotrophin 1 GO:0005125,GO:0005146,GO:0005576,GO:0005615,GO:0007166,GO:0007267,GO:0007399,GO:0007517,GO:0008283,GO:0008284,GO:0019221,GO:0042531,GO:0048666,GO:0048861 cytokine activity|leukemia inhibitory factor receptor binding|extracellular region|extracellular space|cell surface receptor signaling pathway|cell-cell signaling|nervous system development|muscle organ development|cell proliferation|positive regulation of cell proliferation|cytokine-mediated signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|neuron development|leukemia inhibitory factor signaling pathway hsa04060,hsa04630 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway CTGF 13568.779457249 14423.202549576 12714.356364922 0.881521029828139 -0.181933107568941 0.156657889319443 1 268.16 275.281 251.522 233.698 GeneID:1490,Genbank:NM_001901.2,HGNC:HGNC:2500,MIM:121009 connective tissue growth factor hsa04371,hsa04390 Apelin signaling pathway|Hippo signaling pathway CTH 216.488153441057 213.446549186782 219.529757695333 1.02849991499852 0.0405416746297719 0.889296881774192 1 1.41622 1.52971 1.64662 1.64368 GeneID:1491,Genbank:NM_001902.5,HGNC:HGNC:2501,MIM:607657 cystathionine gamma-lyase GO:0000098,GO:0003962,GO:0004123,GO:0005516,GO:0005737,GO:0005829,GO:0006534,GO:0016846,GO:0018272,GO:0019343,GO:0019344,GO:0019346,GO:0030170,GO:0030968,GO:0042802,GO:0043123,GO:0044524,GO:0044540,GO:0047982,GO:0051092,GO:0051289,GO:0070062,GO:0070814,GO:0071266,GO:0080146,GO:1904831,GO:1990830,GO:2001234 sulfur amino acid catabolic process|cystathionine gamma-synthase activity|cystathionine gamma-lyase activity|calmodulin binding|cytoplasm|cytosol|cysteine metabolic process|carbon-sulfur lyase activity|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine|cysteine biosynthetic process via cystathionine|cysteine biosynthetic process|transsulfuration|pyridoxal phosphate binding|endoplasmic reticulum unfolded protein response|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein sulfhydration|L-cystine L-cysteine-lyase (deaminating)|homocysteine desulfhydrase activity|positive regulation of NF-kappaB transcription factor activity|protein homotetramerization|extracellular exosome|hydrogen sulfide biosynthetic process|'de novo' L-methionine biosynthetic process|L-cysteine desulfhydrase activity|positive regulation of aortic smooth muscle cell differentiation|cellular response to leukemia inhibitory factor|negative regulation of apoptotic signaling pathway hsa00260,hsa00270,hsa00450 Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Selenocompound metabolism CTHRC1 14.8315904541993 19.4871862187087 10.1759946896898 0.522189020799746 -0.937355970067469 0.213259549903921 1 0.575597 0.571117 0.310053 0.351138 GeneID:115908,Genbank:NM_138455.3,HGNC:HGNC:18831,MIM:610635 collagen triple helix repeat containing 1 CTIF 253.222032547709 223.93894538088 282.505119714539 1.26152741870803 0.335171562956481 0.17471999141242 1 1.30134 1.10778 1.38865 1.74835 GeneID:9811,Genbank:NM_001142397.1,HGNC:HGNC:23925,MIM:613178 cap binding complex dependent translation initiation factor GO:0000184,GO:0003723,GO:0005829,GO:0006446,GO:0048471 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|cytosol|regulation of translational initiation|perinuclear region of cytoplasm CTNNA1 11310.9624244565 10660.8748319453 11961.0500169676 1.12195764470721 0.166018213447361 0.202370163493372 1 60.8546 61.5203 70.3913 68.0309 GeneID:1495,Genbank:NM_001323982.1,HGNC:HGNC:2509,MIM:116805 catenin alpha 1 GO:0001541,GO:0001669,GO:0005198,GO:0005794,GO:0005829,GO:0005886,GO:0005911,GO:0005912,GO:0005913,GO:0005915,GO:0007015,GO:0007163,GO:0007406,GO:0007568,GO:0008013,GO:0008584,GO:0014704,GO:0015629,GO:0016264,GO:0016342,GO:0016600,GO:0017166,GO:0030027,GO:0030054,GO:0031103,GO:0034613,GO:0042127,GO:0042475,GO:0042802,GO:0043066,GO:0043231,GO:0043297,GO:0043627,GO:0045295,GO:0045296,GO:0045880,GO:0046982,GO:0051015,GO:0051291,GO:0071681,GO:0090136,GO:2000146,GO:2001045,GO:2001240,GO:2001241 ovarian follicle development|acrosomal vesicle|structural molecule activity|Golgi apparatus|cytosol|plasma membrane|cell-cell junction|adherens junction|cell-cell adherens junction|zonula adherens|actin filament organization|establishment or maintenance of cell polarity|negative regulation of neuroblast proliferation|aging|beta-catenin binding|male gonad development|intercalated disc|actin cytoskeleton|gap junction assembly|catenin complex|flotillin complex|vinculin binding|lamellipodium|cell junction|axon regeneration|cellular protein localization|regulation of cell proliferation|odontogenesis of dentin-containing tooth|identical protein binding|negative regulation of apoptotic process|intracellular membrane-bounded organelle|apical junction assembly|response to estrogen|gamma-catenin binding|cadherin binding|positive regulation of smoothened signaling pathway|protein heterodimerization activity|actin filament binding|protein heterooligomerization|cellular response to indole-3-methanol|epithelial cell-cell adhesion|negative regulation of cell motility|negative regulation of integrin-mediated signaling pathway|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa04390,hsa04520,hsa04670,hsa05100,hsa05200,hsa05213,hsa05226,hsa05412 Hippo signaling pathway|Adherens junction|Leukocyte transendothelial migration|Bacterial invasion of epithelial cells|Pathways in cancer|Endometrial cancer|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy (ARVC) CTNNA2 3.78222348091369 5.14084539299833 2.42360156882906 0.471440275587732 -1.08485308023518 0.543272622660938 1 0.0060162 0.0224563 0.0114938 0.00534096 GeneID:1496,Genbank:XM_024452716.1,HGNC:HGNC:2510,MIM:114025 catenin alpha 2 GO:0005198,GO:0005634,GO:0005737,GO:0005912,GO:0005913,GO:0007409,GO:0014069,GO:0015629,GO:0016323,GO:0021942,GO:0030027,GO:0030424,GO:0042802,GO:0045296,GO:0048813,GO:0048854,GO:0051015,GO:0051823,GO:0060134,GO:0098609 structural molecule activity|nucleus|cytoplasm|adherens junction|cell-cell adherens junction|axonogenesis|postsynaptic density|actin cytoskeleton|basolateral plasma membrane|radial glia guided migration of Purkinje cell|lamellipodium|axon|identical protein binding|cadherin binding|dendrite morphogenesis|brain morphogenesis|actin filament binding|regulation of synapse structural plasticity|prepulse inhibition|cell-cell adhesion hsa04390,hsa04520,hsa04670,hsa05100,hsa05200,hsa05213,hsa05226,hsa05412 Hippo signaling pathway|Adherens junction|Leukocyte transendothelial migration|Bacterial invasion of epithelial cells|Pathways in cancer|Endometrial cancer|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy (ARVC) CTNNA3 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0062329 0 0 GeneID:29119,Genbank:NM_013266.3,HGNC:HGNC:2511,MIM:607667 catenin alpha 3 GO:0005737,GO:0005856,GO:0005916,GO:0008013,GO:0030027,GO:0045296,GO:0051015,GO:0086073,GO:0086091,GO:0098609,GO:0098911 cytoplasm|cytoskeleton|fascia adherens|beta-catenin binding|lamellipodium|cadherin binding|actin filament binding|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|regulation of heart rate by cardiac conduction|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential hsa04390,hsa04520,hsa04670,hsa05100,hsa05200,hsa05213,hsa05226,hsa05412 Hippo signaling pathway|Adherens junction|Leukocyte transendothelial migration|Bacterial invasion of epithelial cells|Pathways in cancer|Endometrial cancer|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy (ARVC) CTNNAL1 1022.5540512665 1000.12035582937 1044.98774670364 1.04486199147208 0.0633123993708549 0.73957024557488 1 11.891 11.6871 14.7732 10.528 GeneID:8727,Genbank:NM_003798.3,HGNC:HGNC:2512,MIM:604785 catenin alpha like 1 CTNNB1 9876.29912898324 10036.1731496229 9716.42510834361 0.96814044192818 -0.0467117496844067 0.73135210621313 1 95.9034 92.8275 96.2419 89.7251 GeneID:1499,Genbank:XM_006712983.2,HGNC:HGNC:2514,MIM:116806 catenin beta 1 hsa04015,hsa04310,hsa04390,hsa04510,hsa04520,hsa04550,hsa04670,hsa04916,hsa04919,hsa04934,hsa05100,hsa05130,hsa05163,hsa05165,hsa05166,hsa05167,hsa05200,hsa05205,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05224,hsa05225,hsa05226,hsa05412,hsa05418 Rap1 signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Focal adhesion|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Leukocyte transendothelial migration|Melanogenesis|Thyroid hormone signaling pathway|Cushing syndrome|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Fluid shear stress and atherosclerosis CTNNBIP1 413.198587571507 345.638315198867 480.758859944148 1.3909304576593 0.476050291269023 0.00966040402750963 0.389725518651371 3.77737 3.78324 5.65017 5.11336 GeneID:56998,Genbank:NM_001012329.1,HGNC:HGNC:16913,MIM:607758 catenin beta interacting protein 1 GO:0001658,GO:0002528,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008013,GO:0009952,GO:0016055,GO:0030178,GO:0030877,GO:0032091,GO:0043392,GO:0043433,GO:0045657,GO:0045669,GO:0048662,GO:0060633,GO:0070016,GO:0072201 branching involved in ureteric bud morphogenesis|regulation of vascular permeability involved in acute inflammatory response|nucleus|nucleoplasm|cytoplasm|cytosol|beta-catenin binding|anterior/posterior pattern specification|Wnt signaling pathway|negative regulation of Wnt signaling pathway|beta-catenin destruction complex|negative regulation of protein binding|negative regulation of DNA binding|negative regulation of DNA binding transcription factor activity|positive regulation of monocyte differentiation|positive regulation of osteoblast differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription initiation from RNA polymerase II promoter|armadillo repeat domain binding|negative regulation of mesenchymal cell proliferation hsa04310 Wnt signaling pathway CTNNBL1 1394.47181350734 1446.50064042164 1342.44298659304 0.928062490315755 -0.107706143593419 0.461245154708908 1 16.1758 16.7203 16.2491 15.2439 GeneID:56259,Genbank:NM_001281495.1,HGNC:HGNC:15879,MIM:611537 catenin beta like 1 GO:0000398,GO:0000974,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006915,GO:0016020,GO:0016445,GO:0019899,GO:0043065 mRNA splicing, via spliceosome|Prp19 complex|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|apoptotic process|membrane|somatic diversification of immunoglobulins|enzyme binding|positive regulation of apoptotic process hsa03040 Spliceosome CTNND1 5053.65820231788 4994.38880640397 5112.9275982318 1.02373439402152 0.0338414593491894 0.801019739732422 1 26.6543 27.133 28.6844 26.4714 GeneID:1500,Genbank:NM_001085458.1,HGNC:HGNC:2515,MIM:601045 catenin delta 1 hsa04015,hsa04520,hsa04670 Rap1 signaling pathway|Adherens junction|Leukocyte transendothelial migration CTNND2 1727.31540148945 1515.96530098489 1938.665501994 1.27883237217533 0.354827169864238 0.0133600943324909 0.47550060184261 8.87947 9.13546 12.8894 10.3606 GeneID:1501,Genbank:NM_001288717.1,HGNC:HGNC:2516,MIM:604275 catenin delta 2 CTNS 520.829833524814 472.708853128169 568.950813921459 1.20359669626749 0.267352051759756 0.127662912938175 1 6.54836 7.18582 8.73907 8.3654 GeneID:1497,Genbank:NM_004937.2,HGNC:HGNC:2518,MIM:606272 cystinosin, lysosomal cystine transporter GO:0002088,GO:0005764,GO:0005765,GO:0005770,GO:0005886,GO:0006520,GO:0006749,GO:0006811,GO:0007420,GO:0007616,GO:0007625,GO:0007628,GO:0008542,GO:0010730,GO:0010918,GO:0015184,GO:0015811,GO:0016021,GO:0042438,GO:0042470,GO:0043231,GO:0045111,GO:0046034,GO:0050890,GO:0055085,GO:0070062 lens development in camera-type eye|lysosome|lysosomal membrane|late endosome|plasma membrane|cellular amino acid metabolic process|glutathione metabolic process|ion transport|brain development|long-term memory|grooming behavior|adult walking behavior|visual learning|negative regulation of hydrogen peroxide biosynthetic process|positive regulation of mitochondrial membrane potential|L-cystine transmembrane transporter activity|L-cystine transport|integral component of membrane|melanin biosynthetic process|melanosome|intracellular membrane-bounded organelle|intermediate filament cytoskeleton|ATP metabolic process|cognition|transmembrane transport|extracellular exosome hsa04142 Lysosome CTPS1 2979.34215305345 3064.00474015936 2894.67956594753 0.94473730017695 -0.0820148749928981 0.544841070627942 1 20.4445 20.4159 20.1819 19.0466 GeneID:1503,Genbank:NM_001905.3,HGNC:HGNC:2519,MIM:123860 CTP synthase 1 GO:0003883,GO:0005524,GO:0005829,GO:0006139,GO:0006241,GO:0006541,GO:0015949,GO:0016020,GO:0042098,GO:0042100,GO:0042493,GO:0042802,GO:0044210 CTP synthase activity|ATP binding|cytosol|nucleobase-containing compound metabolic process|CTP biosynthetic process|glutamine metabolic process|nucleobase-containing small molecule interconversion|membrane|T cell proliferation|B cell proliferation|response to drug|identical protein binding|'de novo' CTP biosynthetic process hsa00240 Pyrimidine metabolism CTPS2 313.783118541007 298.995288118655 328.570948963359 1.09891681247153 0.136082179028556 0.479173700197643 1 2.09989 1.94013 2.36815 2.30404 GeneID:56474,Genbank:NM_019857.4,HGNC:HGNC:2520,MIM:300380 CTP synthase 2 GO:0003883,GO:0005524,GO:0005739,GO:0005829,GO:0006220,GO:0006541,GO:0015949,GO:0044210 CTP synthase activity|ATP binding|mitochondrion|cytosol|pyrimidine nucleotide metabolic process|glutamine metabolic process|nucleobase-containing small molecule interconversion|'de novo' CTP biosynthetic process hsa00240 Pyrimidine metabolism CTR9 455.099387751219 473.495873832489 436.702901669948 0.922295052193935 -0.116699736595599 0.548232575563674 1 3.43389 3.05784 3.52941 2.5327 GeneID:9646,Genbank:NM_014633.4,HGNC:HGNC:16850,MIM:609366 CTR9 homolog, Paf1/RNA polymerase II complex component GO:0000122,GO:0000993,GO:0001711,GO:0001826,GO:0001829,GO:0001832,GO:0005654,GO:0006366,GO:0006368,GO:0007259,GO:0010390,GO:0016055,GO:0016567,GO:0016593,GO:0016607,GO:0019827,GO:0032968,GO:0033523,GO:0035327,GO:0042169,GO:0045638,GO:0045944,GO:0051571,GO:0070102,GO:0071222,GO:0080182,GO:1900364,GO:2000653,GO:2001162,GO:2001168 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II core binding|endodermal cell fate commitment|inner cell mass cell differentiation|trophectodermal cell differentiation|blastocyst growth|nucleoplasm|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|JAK-STAT cascade|histone monoubiquitination|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|nuclear speck|stem cell population maintenance|positive regulation of transcription elongation from RNA polymerase II promoter|histone H2B ubiquitination|transcriptionally active chromatin|SH2 domain binding|negative regulation of myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|interleukin-6-mediated signaling pathway|cellular response to lipopolysaccharide|histone H3-K4 trimethylation|negative regulation of mRNA polyadenylation|regulation of genetic imprinting|positive regulation of histone H3-K79 methylation|positive regulation of histone H2B ubiquitination CTRC 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.032017 0 GeneID:11330,Genbank:XM_011540550.1,HGNC:HGNC:2523,MIM:601405 chymotrypsin C GO:0004252,GO:0005576,GO:0006508,GO:0008233,GO:0009235 serine-type endopeptidase activity|extracellular region|proteolysis|peptidase activity|cobalamin metabolic process CTRL 13.3546427995091 14.1062094522857 12.6030761467324 0.893441727869022 -0.162554458128597 0.853681207491404 1 0.296647 0.521584 0.461357 0.301476 GeneID:1506,Genbank:NM_001907.2,HGNC:HGNC:2524,MIM:118888 chymotrypsin like GO:0004252,GO:0005615,GO:0006508,GO:0007586 serine-type endopeptidase activity|extracellular space|proteolysis|digestion hsa04972,hsa04974 Pancreatic secretion|Protein digestion and absorption CTSA 5768.8877417535 5625.53785219098 5912.23763131602 1.0509639765402 0.0717132194832526 0.610867589692861 1 72.0468 77.606 77.9061 81.5038 GeneID:5476,Genbank:NM_001127695.2,HGNC:HGNC:9251,MIM:613111 cathepsin A GO:0004180,GO:0004185,GO:0004308,GO:0005576,GO:0005654,GO:0005764,GO:0005783,GO:0006508,GO:0006687,GO:0006886,GO:0008047,GO:0016020,GO:0031647,GO:0035578,GO:0043202,GO:0043231,GO:0043312,GO:0051603,GO:0070062,GO:1904714,GO:1904715 carboxypeptidase activity|serine-type carboxypeptidase activity|exo-alpha-sialidase activity|extracellular region|nucleoplasm|lysosome|endoplasmic reticulum|proteolysis|glycosphingolipid metabolic process|intracellular protein transport|enzyme activator activity|membrane|regulation of protein stability|azurophil granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|proteolysis involved in cellular protein catabolic process|extracellular exosome|regulation of chaperone-mediated autophagy|negative regulation of chaperone-mediated autophagy hsa04142,hsa04614 Lysosome|Renin-angiotensin system CTSB 17970.2214061956 17576.7209195076 18363.7218928836 1.04477518741864 0.0631925395418162 0.659180500268313 1 118.935 125.426 123.048 138.958 GeneID:1508,Genbank:NM_001908.4,HGNC:HGNC:2527,MIM:116810 cathepsin B hsa04140,hsa04142,hsa04210,hsa04612,hsa04621,hsa04924 Autophagy - animal|Lysosome|Apoptosis|Antigen processing and presentation|NOD-like receptor signaling pathway|Renin secretion CTSC 2389.12474152503 2312.30728249853 2465.94220055153 1.0664422584385 0.0928058543614842 0.511919548739694 1 10.6695 12.1128 13.5413 11.0066 GeneID:1075,Genbank:NM_001814.5,HGNC:HGNC:2528,MIM:602365 cathepsin C GO:0003964,GO:0006310,GO:0009036,GO:0032197,GO:0032199,GO:0046872,GO:0090305 RNA-directed DNA polymerase activity|DNA recombination|Type II site-specific deoxyribonuclease activity|transposition, RNA-mediated|reverse transcription involved in RNA-mediated transposition|metal ion binding|nucleic acid phosphodiester bond hydrolysis hsa04142,hsa04210 Lysosome|Apoptosis CTSD 25859.5286349476 23536.9335809642 28182.123688931 1.19735748890092 0.259853954674755 0.112120793439778 1 457.989 487.347 545.384 608.387 GeneID:1509,Genbank:NM_001909.4,HGNC:HGNC:2529,MIM:116840 cathepsin D hsa04071,hsa04140,hsa04142,hsa04210,hsa04915,hsa05152 Sphingolipid signaling pathway|Autophagy - animal|Lysosome|Apoptosis|Estrogen signaling pathway|Tuberculosis CTSE 3.51567619227764 5.09281911831339 1.93853326624189 0.380640509942925 -1.39349898523626 0.44014221031611 1 0.0544019 0.0495113 0.0171368 0 GeneID:1510,Genbank:NM_001317331.1,HGNC:HGNC:2530,MIM:116890 cathepsin E GO:0004190,GO:0005768,GO:0007586,GO:0016540,GO:0019886,GO:0030163,GO:0042803,GO:0070062 aspartic-type endopeptidase activity|endosome|digestion|protein autoprocessing|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein catabolic process|protein homodimerization activity|extracellular exosome hsa04142 Lysosome CTSF 430.364885258585 449.791167095758 410.938603421411 0.913620883386365 -0.130332466938786 0.462177260392998 1 7.84825 8.18836 6.89183 7.80663 GeneID:8722,Genbank:XM_011545328.2,HGNC:HGNC:2531,MIM:603539 cathepsin F GO:0004197,GO:0005615,GO:0005764,GO:0006508,GO:0019886,GO:0043202,GO:0051603,GO:0070062,GO:1903561 cysteine-type endopeptidase activity|extracellular space|lysosome|proteolysis|antigen processing and presentation of exogenous peptide antigen via MHC class II|lysosomal lumen|proteolysis involved in cellular protein catabolic process|extracellular exosome|extracellular vesicle hsa04142,hsa04210 Lysosome|Apoptosis CTSH 428.222118639915 412.565357857215 443.878879422615 1.07589954165817 0.1055433775994 0.568478729585621 1 4.20596 3.968 4.09663 4.65902 GeneID:1512,Genbank:NM_004390.4,HGNC:HGNC:2535,MIM:116820 cathepsin H hsa04142,hsa04210 Lysosome|Apoptosis CTSK 41.3412567107635 47.3055862706926 35.3769271508343 0.747838256319244 -0.419201819478484 0.336475852622953 1 0.594646 0.812159 0.546252 0.620917 GeneID:1513,Genbank:NM_000396.3,HGNC:HGNC:2536,MIM:601105 cathepsin K GO:0001957,GO:0001968,GO:0002224,GO:0004197,GO:0004252,GO:0005518,GO:0005576,GO:0005615,GO:0005654,GO:0005764,GO:0006508,GO:0008234,GO:0022617,GO:0030574,GO:0036021,GO:0043202,GO:0043231,GO:0043394,GO:0045453,GO:0045616,GO:0051603,GO:1903146,GO:1903955 intramembranous ossification|fibronectin binding|toll-like receptor signaling pathway|cysteine-type endopeptidase activity|serine-type endopeptidase activity|collagen binding|extracellular region|extracellular space|nucleoplasm|lysosome|proteolysis|cysteine-type peptidase activity|extracellular matrix disassembly|collagen catabolic process|endolysosome lumen|lysosomal lumen|intracellular membrane-bounded organelle|proteoglycan binding|bone resorption|regulation of keratinocyte differentiation|proteolysis involved in cellular protein catabolic process|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion hsa04142,hsa04210,hsa04380,hsa04620,hsa05323 Lysosome|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|Rheumatoid arthritis CTSL 2439.95627790058 2199.9399036288 2679.97265217236 1.21820266442358 0.284754164965587 0.0420687111733348 0.765650543354693 29.2472 31.3372 37.4723 37.0548 GeneID:1514,Genbank:XM_017014293.2,HGNC:HGNC:2537,MIM:116880 cathepsin L hsa04140,hsa04142,hsa04145,hsa04210,hsa04612,hsa05205,hsa05323,hsa05418 Autophagy - animal|Lysosome|Phagosome|Apoptosis|Antigen processing and presentation|Proteoglycans in cancer|Rheumatoid arthritis|Fluid shear stress and atherosclerosis CTSO 94.2976323386718 74.7103501598731 113.88491451747 1.52435257328827 0.608196627834875 0.0444602150071539 0.785206567052859 1.27295 1.08547 1.76942 1.64639 GeneID:1519,Genbank:NM_001334.2,HGNC:HGNC:2542,MIM:600550 cathepsin O GO:0004197,GO:0005615,GO:0005764,GO:0006508,GO:0051603 cysteine-type endopeptidase activity|extracellular space|lysosome|proteolysis|proteolysis involved in cellular protein catabolic process hsa04142,hsa04210 Lysosome|Apoptosis CTSS 6.77924702054801 8.22535262879733 5.33314141229868 0.648378452934299 -0.625091947217215 0.623806885397318 1 0.0831196 0.0700887 0.080101 0.0279512 GeneID:1520,Genbank:NM_001199739.1,HGNC:HGNC:2545,MIM:116845 cathepsin S GO:0001968,GO:0002224,GO:0002250,GO:0004197,GO:0004252,GO:0005518,GO:0005576,GO:0005615,GO:0005764,GO:0006508,GO:0006955,GO:0010447,GO:0016485,GO:0019882,GO:0019886,GO:0022617,GO:0030574,GO:0034769,GO:0036021,GO:0043202,GO:0043231,GO:0043236,GO:0043312,GO:0043394,GO:0048002,GO:0051603,GO:0097067,GO:1904724,GO:1904813,GO:2001259 fibronectin binding|toll-like receptor signaling pathway|adaptive immune response|cysteine-type endopeptidase activity|serine-type endopeptidase activity|collagen binding|extracellular region|extracellular space|lysosome|proteolysis|immune response|response to acidic pH|protein processing|antigen processing and presentation|antigen processing and presentation of exogenous peptide antigen via MHC class II|extracellular matrix disassembly|collagen catabolic process|basement membrane disassembly|endolysosome lumen|lysosomal lumen|intracellular membrane-bounded organelle|laminin binding|neutrophil degranulation|proteoglycan binding|antigen processing and presentation of peptide antigen|proteolysis involved in cellular protein catabolic process|cellular response to thyroid hormone stimulus|tertiary granule lumen|ficolin-1-rich granule lumen|positive regulation of cation channel activity hsa04142,hsa04145,hsa04210,hsa04612,hsa05152 Lysosome|Phagosome|Apoptosis|Antigen processing and presentation|Tuberculosis CTSV 110.031318309267 112.964328477016 107.098308141517 0.948071923105418 -0.076931585160929 0.788371952742485 1 0.8081 1.02726 0.769573 0.89452 GeneID:1515,Genbank:NM_001201575.1,HGNC:HGNC:2538,MIM:603308 cathepsin V GO:0004177,GO:0004197,GO:0004252,GO:0005576,GO:0005615,GO:0005730,GO:0005764,GO:0005902,GO:0007283,GO:0008234,GO:0009267,GO:0009749,GO:0009897,GO:0010259,GO:0010839,GO:0016540,GO:0016807,GO:0019886,GO:0021675,GO:0022617,GO:0030141,GO:0030984,GO:0031069,GO:0032403,GO:0034698,GO:0042277,GO:0042393,GO:0043005,GO:0043202,GO:0043204,GO:0045177,GO:0045616,GO:0046697,GO:0048102,GO:0051384,GO:0051603,GO:0060008,GO:0070062,GO:1990834,GO:2000249 aminopeptidase activity|cysteine-type endopeptidase activity|serine-type endopeptidase activity|extracellular region|extracellular space|nucleolus|lysosome|microvillus|spermatogenesis|cysteine-type peptidase activity|cellular response to starvation|response to glucose|external side of plasma membrane|multicellular organism aging|negative regulation of keratinocyte proliferation|protein autoprocessing|cysteine-type carboxypeptidase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|nerve development|extracellular matrix disassembly|secretory granule|kininogen binding|hair follicle morphogenesis|protein complex binding|response to gonadotropin|peptide binding|histone binding|neuron projection|lysosomal lumen|perikaryon|apical part of cell|regulation of keratinocyte differentiation|decidualization|autophagic cell death|response to glucocorticoid|proteolysis involved in cellular protein catabolic process|Sertoli cell differentiation|extracellular exosome|response to odorant|regulation of actin cytoskeleton reorganization hsa04142,hsa04210 Lysosome|Apoptosis CTSW 1.70524370811038 1.47021420587209 1.94027321034868 1.31972144099762 0.40023344617379 1 1 0 0.0832932 0.0294738 0 GeneID:1521,Genbank:NM_001335.3,HGNC:HGNC:2546,MIM:602364 cathepsin W GO:0002576,GO:0004197,GO:0005576,GO:0005615,GO:0005764,GO:0006955,GO:0008234,GO:0016020,GO:0031089,GO:0051603 platelet degranulation|cysteine-type endopeptidase activity|extracellular region|extracellular space|lysosome|immune response|cysteine-type peptidase activity|membrane|platelet dense granule lumen|proteolysis involved in cellular protein catabolic process hsa04142,hsa04210 Lysosome|Apoptosis CTSZ 593.860075579891 598.443447020546 589.276704139237 0.984682357327252 -0.0222696854601695 0.885885498038179 1 13.0861 13.9354 13.2657 14.149 GeneID:1522,Genbank:NM_001336.3,HGNC:HGNC:2547,MIM:603169 cathepsin Z GO:0000139,GO:0002003,GO:0004180,GO:0004197,GO:0005576,GO:0005615,GO:0005764,GO:0005783,GO:0005788,GO:0005886,GO:0006508,GO:0006888,GO:0008234,GO:0009986,GO:0010757,GO:0010977,GO:0030134,GO:0030426,GO:0031410,GO:0032091,GO:0033116,GO:0035580,GO:0043231,GO:0043312,GO:0043525,GO:0048208,GO:0051603,GO:0060441,GO:0070062,GO:0099738,GO:1901214,GO:1904813,GO:2000179 Golgi membrane|angiotensin maturation|carboxypeptidase activity|cysteine-type endopeptidase activity|extracellular region|extracellular space|lysosome|endoplasmic reticulum|endoplasmic reticulum lumen|plasma membrane|proteolysis|ER to Golgi vesicle-mediated transport|cysteine-type peptidase activity|cell surface|negative regulation of plasminogen activation|negative regulation of neuron projection development|COPII-coated ER to Golgi transport vesicle|growth cone|cytoplasmic vesicle|negative regulation of protein binding|endoplasmic reticulum-Golgi intermediate compartment membrane|specific granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|positive regulation of neuron apoptotic process|COPII vesicle coating|proteolysis involved in cellular protein catabolic process|epithelial tube branching involved in lung morphogenesis|extracellular exosome|cell cortex region|regulation of neuron death|ficolin-1-rich granule lumen|positive regulation of neural precursor cell proliferation hsa04142,hsa04210 Lysosome|Apoptosis CTTN 4891.22663352237 4448.10261639815 5334.3506506466 1.19924181402229 0.262122591793097 0.0480982624387159 0.805544588686926 31.6493 30.2714 39.6269 36.8296 GeneID:2017,Genbank:NM_005231.3,HGNC:HGNC:3338,MIM:164765 cortactin hsa04530,hsa05100,hsa05130,hsa05131,hsa05205 Tight junction|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Proteoglycans in cancer CTTNBP2 11.9826431669455 6.51500704950053 17.4502792843906 2.67847435187785 1.42141148138673 0.102879325712737 1 0.0116714 0.0331128 0.0670305 0.0415868 GeneID:83992,Genbank:XM_024446965.1,HGNC:HGNC:15679,MIM:609772 cortactin binding protein 2 GO:0005938,GO:0007420,GO:0008021,GO:0017124,GO:0043197 cell cortex|brain development|synaptic vesicle|SH3 domain binding|dendritic spine CTTNBP2NL 462.392434721635 503.091246047816 421.693623395455 0.838205050690497 -0.254624880285711 0.368985529413262 1 3.02498 2.56334 2.87233 1.89936 GeneID:55917,Genbank:XM_017001806.1,HGNC:HGNC:25330,MIM:615100 CTTNBP2 N-terminal like GO:0005737,GO:0006470,GO:0015629,GO:0032410,GO:0034763,GO:0051721 cytoplasm|protein dephosphorylation|actin cytoskeleton|negative regulation of transporter activity|negative regulation of transmembrane transport|protein phosphatase 2A binding CTU1 167.219879054386 171.608183576774 162.831574531998 0.948856698661752 -0.0757378745964565 0.773884698646629 1 5.09604 4.57592 4.84302 4.97394 GeneID:90353,Genbank:NM_145232.3,HGNC:HGNC:29590,MIM:612694 cytosolic thiouridylase subunit 1 GO:0000049,GO:0002098,GO:0005739,GO:0005829,GO:0006400,GO:0016740,GO:0034227 tRNA binding|tRNA wobble uridine modification|mitochondrion|cytosol|tRNA modification|transferase activity|tRNA thio-modification hsa04122 Sulfur relay system CTU2 619.6922427105 654.474265977101 584.910219443899 0.893710035444487 -0.16212127050636 0.317032430074361 1 11.5636 13.0012 10.7227 11.6688 GeneID:348180,Genbank:NM_001318507.1,HGNC:HGNC:28005,MIM:617057 cytosolic thiouridylase subunit 2 GO:0000049,GO:0002098,GO:0002143,GO:0005829,GO:0006400,GO:0016783,GO:0034227,GO:0043234 tRNA binding|tRNA wobble uridine modification|tRNA wobble position uridine thiolation|cytosol|tRNA modification|sulfurtransferase activity|tRNA thio-modification|protein complex hsa04122 Sulfur relay system CTXN1 350.827875345844 357.553916325006 344.101834366682 0.962377472755476 -0.0553252224526896 0.753275306003684 1 21.0057 21.86 22.589 19.709 GeneID:404217,Genbank:NM_206833.3,HGNC:HGNC:31108,MIM:600135 cortexin 1 GO:0016021 integral component of membrane CTXN2 4.9342518477961 3.084507235799 6.7839964597932 2.19937770968979 1.13709538641336 0.437206115039626 1 0.0274437 0.0262935 0.0394161 0.0245531 GeneID:399697,Genbank:XM_005254378.3,HGNC:HGNC:31109 cortexin 2 GO:0016021 integral component of membrane CTXND1 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00531673 0 0.00505723 0 GeneID:100996492,Genbank:NM_001352888.1,HGNC:HGNC:50507 cortexin domain containing 1 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding CUBN 128.358839749786 120.545722224694 136.171957274878 1.12962911301869 0.175849175614842 0.520912566666408 1 0.233443 0.253349 0.248577 0.276272 GeneID:8029,Genbank:NM_001081.3,HGNC:HGNC:2548,MIM:602997 cubilin GO:0001894,GO:0004872,GO:0005215,GO:0005509,GO:0005765,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0005905,GO:0006898,GO:0008144,GO:0008203,GO:0009235,GO:0010008,GO:0015889,GO:0016020,GO:0016324,GO:0030139,GO:0031232,GO:0031419,GO:0031526,GO:0034384,GO:0042359,GO:0042803,GO:0042953,GO:0043202,GO:0070062 tissue homeostasis|receptor activity|transporter activity|calcium ion binding|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|clathrin-coated pit|receptor-mediated endocytosis|drug binding|cholesterol metabolic process|cobalamin metabolic process|endosome membrane|cobalamin transport|membrane|apical plasma membrane|endocytic vesicle|extrinsic component of external side of plasma membrane|cobalamin binding|brush border membrane|high-density lipoprotein particle clearance|vitamin D metabolic process|protein homodimerization activity|lipoprotein transport|lysosomal lumen|extracellular exosome hsa04977 Vitamin digestion and absorption CUEDC1 3564.51133854929 3577.27690079297 3551.74577630561 0.992862972256437 -0.0103334736969483 0.912546705962679 1 30.5424 33.304 32.605 33.3421 GeneID:404093,Genbank:NM_001271875.1,HGNC:HGNC:31350 CUE domain containing 1 CUEDC2 1637.02889044448 1625.51097230502 1648.54680858394 1.01417144311628 0.0203015569037448 0.954306647174876 1 38.7085 45.3063 39.5719 47.063 GeneID:79004,Genbank:NM_024040.2,HGNC:HGNC:28352,MIM:614142 CUE domain containing 2 GO:0005654,GO:0005829,GO:0010936,GO:0031965,GO:1900016 nucleoplasm|cytosol|negative regulation of macrophage cytokine production|nuclear membrane|negative regulation of cytokine production involved in inflammatory response CUL1 2170.84298356876 2244.55972516712 2097.1262419704 0.93431518816647 -0.0980187743990338 0.502346767551937 1 20.128 18.0878 19.3295 16.3145 GeneID:8454,Genbank:XM_011516630.3,HGNC:HGNC:2551,MIM:603134 cullin 1 GO:0000082,GO:0000086,GO:0000209,GO:0002223,GO:0004842,GO:0005654,GO:0005829,GO:0006513,GO:0006879,GO:0007050,GO:0008283,GO:0008285,GO:0009887,GO:0010265,GO:0010972,GO:0016032,GO:0016055,GO:0016567,GO:0019005,GO:0031146,GO:0031461,GO:0031625,GO:0038061,GO:0038095,GO:0042787,GO:0043161,GO:0043687,GO:0050852,GO:0051403,GO:0051437,GO:0070498,GO:0097193,GO:1990452 G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|ubiquitin-protein transferase activity|nucleoplasm|cytosol|protein monoubiquitination|cellular iron ion homeostasis|cell cycle arrest|cell proliferation|negative regulation of cell proliferation|animal organ morphogenesis|SCF complex assembly|negative regulation of G2/M transition of mitotic cell cycle|viral process|Wnt signaling pathway|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cullin-RING ubiquitin ligase complex|ubiquitin protein ligase binding|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|T cell receptor signaling pathway|stress-activated MAPK cascade|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|interleukin-1-mediated signaling pathway|intrinsic apoptotic signaling pathway|Parkin-FBXW7-Cul1 ubiquitin ligase complex hsa04110,hsa04114,hsa04120,hsa04141,hsa04310,hsa04340,hsa04350,hsa04710,hsa05168,hsa05170,hsa05200 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Wnt signaling pathway|Hedgehog signaling pathway|TGF-beta signaling pathway|Circadian rhythm|Herpes simplex infection|Human immunodeficiency virus 1 infection|Pathways in cancer CUL2 406.307355842268 419.041130286284 393.573581398253 0.939224226341144 -0.0904584730967034 0.721025630420078 1 2.35999 2.15355 2.63382 1.75224 GeneID:8453,Genbank:XM_011519745.1,HGNC:HGNC:2552,MIM:603135 cullin 2 GO:0000082,GO:0005654,GO:0005730,GO:0005829,GO:0007050,GO:0008285,GO:0016032,GO:0016567,GO:0030891,GO:0031462,GO:0031625,GO:0032403,GO:0042787,GO:0043687,GO:0061418,GO:0097193 G1/S transition of mitotic cell cycle|nucleoplasm|nucleolus|cytosol|cell cycle arrest|negative regulation of cell proliferation|viral process|protein ubiquitination|VCB complex|Cul2-RING ubiquitin ligase complex|ubiquitin protein ligase binding|protein complex binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|post-translational protein modification|regulation of transcription from RNA polymerase II promoter in response to hypoxia|intrinsic apoptotic signaling pathway hsa04066,hsa04120,hsa05200,hsa05211 HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Pathways in cancer|Renal cell carcinoma CUL3 1165.70005606987 1245.7370957551 1085.66301638464 0.871502518536276 -0.198423261317188 0.192861976977137 1 5.99475 5.73197 5.98488 4.64941 GeneID:8452,Genbank:NM_001257197.1,HGNC:HGNC:2553,MIM:603136 cullin 3 GO:0000082,GO:0000122,GO:0000139,GO:0000165,GO:0000209,GO:0001831,GO:0005112,GO:0005654,GO:0005827,GO:0005829,GO:0006511,GO:0006513,GO:0006888,GO:0007050,GO:0007080,GO:0007229,GO:0007369,GO:0008284,GO:0016020,GO:0016055,GO:0016477,GO:0016567,GO:0017145,GO:0030030,GO:0030332,GO:0031145,GO:0031208,GO:0031463,GO:0031625,GO:0032467,GO:0035024,GO:0040016,GO:0042787,GO:0042803,GO:0043149,GO:0043161,GO:0043687,GO:0044346,GO:0045842,GO:0046982,GO:0048208,GO:0070062,GO:0071630,GO:0072576,GO:0090090,GO:0097193 G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|Golgi membrane|MAPK cascade|protein polyubiquitination|trophectodermal cellular morphogenesis|Notch binding|nucleoplasm|polar microtubule|cytosol|ubiquitin-dependent protein catabolic process|protein monoubiquitination|ER to Golgi vesicle-mediated transport|cell cycle arrest|mitotic metaphase plate congression|integrin-mediated signaling pathway|gastrulation|positive regulation of cell proliferation|membrane|Wnt signaling pathway|cell migration|protein ubiquitination|stem cell division|cell projection organization|cyclin binding|anaphase-promoting complex-dependent catabolic process|POZ domain binding|Cul3-RING ubiquitin ligase complex|ubiquitin protein ligase binding|positive regulation of cytokinesis|negative regulation of Rho protein signal transduction|embryonic cleavage|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein homodimerization activity|stress fiber assembly|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|fibroblast apoptotic process|positive regulation of mitotic metaphase/anaphase transition|protein heterodimerization activity|COPII vesicle coating|extracellular exosome|nuclear protein quality control by the ubiquitin-proteasome system|liver morphogenesis|negative regulation of canonical Wnt signaling pathway|intrinsic apoptotic signaling pathway hsa04120,hsa04340 Ubiquitin mediated proteolysis|Hedgehog signaling pathway CUL4A 1942.41195604687 1966.62871567838 1918.19519641536 0.975372311572137 -0.0359750765063505 0.810427247526738 1 10.0396 9.74846 10.0733 9.38427 GeneID:8451,Genbank:NM_001278513.2,HGNC:HGNC:2554,MIM:603137 cullin 4A GO:0000082,GO:0000715,GO:0000717,GO:0001701,GO:0005654,GO:0006283,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006974,GO:0007050,GO:0008284,GO:0008285,GO:0016032,GO:0016567,GO:0030097,GO:0030853,GO:0031464,GO:0031625,GO:0033683,GO:0035019,GO:0042769,GO:0042787,GO:0043161,GO:0043687,GO:0051246,GO:0070911,GO:0080008,GO:0097193,GO:1900087,GO:2000001,GO:2000819 G1/S transition of mitotic cell cycle|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|in utero embryonic development|nucleoplasm|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|cellular response to DNA damage stimulus|cell cycle arrest|positive regulation of cell proliferation|negative regulation of cell proliferation|viral process|protein ubiquitination|hemopoiesis|negative regulation of granulocyte differentiation|Cul4A-RING E3 ubiquitin ligase complex|ubiquitin protein ligase binding|nucleotide-excision repair, DNA incision|somatic stem cell population maintenance|DNA damage response, detection of DNA damage|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|regulation of protein metabolic process|global genome nucleotide-excision repair|Cul4-RING E3 ubiquitin ligase complex|intrinsic apoptotic signaling pathway|positive regulation of G1/S transition of mitotic cell cycle|regulation of DNA damage checkpoint|regulation of nucleotide-excision repair hsa03420,hsa04120,hsa05170 Nucleotide excision repair|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection CUL4B 2496.9051470012 2549.906324201 2443.90396980139 0.958428922116256 -0.0612566504875863 0.833402110601103 1 14.9476 13.4875 16.4398 10.9507 GeneID:8450,Genbank:NM_003588.3,HGNC:HGNC:2555,MIM:300304 cullin 4B GO:0000715,GO:0000717,GO:0005654,GO:0005829,GO:0006283,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0007049,GO:0010498,GO:0016567,GO:0031175,GO:0031465,GO:0031625,GO:0033683,GO:0035518,GO:0042769,GO:0042787,GO:0043687,GO:0045732,GO:0070062,GO:0070911,GO:0070914,GO:0080008,GO:1900087 nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|cell cycle|proteasomal protein catabolic process|protein ubiquitination|neuron projection development|Cul4B-RING E3 ubiquitin ligase complex|ubiquitin protein ligase binding|nucleotide-excision repair, DNA incision|histone H2A monoubiquitination|DNA damage response, detection of DNA damage|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|post-translational protein modification|positive regulation of protein catabolic process|extracellular exosome|global genome nucleotide-excision repair|UV-damage excision repair|Cul4-RING E3 ubiquitin ligase complex|positive regulation of G1/S transition of mitotic cell cycle hsa03420,hsa04120,hsa05170 Nucleotide excision repair|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection CUL5 194.817962928306 195.284481349036 194.351444507577 0.995222165965193 -0.00690947681038982 1 1 1.19871 0.973916 1.30689 1.01047 GeneID:8065,Genbank:NM_003478.4,HGNC:HGNC:2556,MIM:601741 cullin 5 GO:0000082,GO:0004842,GO:0004872,GO:0005262,GO:0005829,GO:0006974,GO:0007050,GO:0008283,GO:0008285,GO:0016032,GO:0031466,GO:0031625,GO:0038128,GO:0042787,GO:0043687,GO:0080008,GO:0097193 G1/S transition of mitotic cell cycle|ubiquitin-protein transferase activity|receptor activity|calcium channel activity|cytosol|cellular response to DNA damage stimulus|cell cycle arrest|cell proliferation|negative regulation of cell proliferation|viral process|Cul5-RING ubiquitin ligase complex|ubiquitin protein ligase binding|ERBB2 signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex|intrinsic apoptotic signaling pathway hsa04120,hsa05170 Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection CUL7 1286.20013518269 1137.43538392594 1434.96488643945 1.26157925691265 0.335230844414116 0.0239933450745272 0.621959897532696 5.66018 6.20346 7.81185 7.44284 GeneID:9820,Genbank:NM_001168370.1,HGNC:HGNC:21024,MIM:609577 cullin 7 GO:0000226,GO:0000281,GO:0001837,GO:0001890,GO:0005737,GO:0005794,GO:0005813,GO:0006511,GO:0007030,GO:0007088,GO:0016567,GO:0031467,GO:0031625,GO:0048471,GO:0050775,GO:1990393 microtubule cytoskeleton organization|mitotic cytokinesis|epithelial to mesenchymal transition|placenta development|cytoplasm|Golgi apparatus|centrosome|ubiquitin-dependent protein catabolic process|Golgi organization|regulation of mitotic nuclear division|protein ubiquitination|Cul7-RING ubiquitin ligase complex|ubiquitin protein ligase binding|perinuclear region of cytoplasm|positive regulation of dendrite morphogenesis|3M complex hsa04120 Ubiquitin mediated proteolysis CUL9 1153.83802688594 1061.75469961726 1245.92135415462 1.17345499351568 0.230762510052915 0.128884236882046 1 4.12038 4.30304 4.86956 5.39559 GeneID:23113,Genbank:XM_011514423.2,HGNC:HGNC:15982,MIM:607489 cullin 9 GO:0000226,GO:0005524,GO:0005829,GO:0006511,GO:0007088,GO:0016567,GO:0031461,GO:0031625,GO:0043687,GO:0046872 microtubule cytoskeleton organization|ATP binding|cytosol|ubiquitin-dependent protein catabolic process|regulation of mitotic nuclear division|protein ubiquitination|cullin-RING ubiquitin ligase complex|ubiquitin protein ligase binding|post-translational protein modification|metal ion binding CUTA 4590.08093205561 4378.21959602126 4801.94226808996 1.09677967556807 0.133273741885469 0.326083651544996 1 165.849 171.909 183.186 196.96 GeneID:51596,Genbank:NM_001014433.2,HGNC:HGNC:21101,MIM:616953 cutA divalent cation tolerance homolog GO:0005507,GO:0008104,GO:0010038,GO:0016020,GO:0019899,GO:0070062 copper ion binding|protein localization|response to metal ion|membrane|enzyme binding|extracellular exosome CUTC 532.501395907312 587.63245021216 477.370341602465 0.812362117561946 -0.299805130093024 0.083253008874153 0.963076417285947 17.3362 16.5696 14.8436 13.1065 GeneID:51076,Genbank:NM_015960.2,HGNC:HGNC:24271,MIM:610101 cutC copper transporter GO:0005507,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006825,GO:0051262,GO:0055070 copper ion binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|copper ion transport|protein tetramerization|copper ion homeostasis CUX1 1940.11988982377 1778.33071247144 2101.9090671761 1.18195623144526 0.241176612633889 0.0879424736605892 0.970228836454666 4.3646 4.40851 5.65369 4.97207 GeneID:1523,Genbank:NM_001913.4,HGNC:HGNC:2557,MIM:116896 cut like homeobox 1 GO:0000122,GO:0000139,GO:0000301,GO:0000977,GO:0004713,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006351,GO:0006357,GO:0007275,GO:0030674,GO:0043565,GO:0048193,GO:0050775 negative regulation of transcription from RNA polymerase II promoter|Golgi membrane|retrograde transport, vesicle recycling within Golgi|RNA polymerase II regulatory region sequence-specific DNA binding|protein tyrosine kinase activity|nucleus|nucleoplasm|Golgi apparatus|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|multicellular organism development|protein binding, bridging|sequence-specific DNA binding|Golgi vesicle transport|positive regulation of dendrite morphogenesis CUX2 6.58136762220087 7.83133377620985 5.33140146819188 0.680778219974189 -0.554743213030734 0.695037811628408 1 0.0278184 0.0124793 0.0156601 0.0073231 GeneID:23316,Genbank:NM_015267.3,HGNC:HGNC:19347,MIM:610648 cut like homeobox 2 GO:0000122,GO:0000139,GO:0000977,GO:0000978,GO:0001078,GO:0005634,GO:0006351,GO:0007275,GO:0007614,GO:0010628,GO:0043565,GO:0048193,GO:0050775,GO:0050890,GO:0051965,GO:0061003,GO:0070062,GO:0071310,GO:2000463 negative regulation of transcription from RNA polymerase II promoter|Golgi membrane|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|transcription, DNA-templated|multicellular organism development|short-term memory|positive regulation of gene expression|sequence-specific DNA binding|Golgi vesicle transport|positive regulation of dendrite morphogenesis|cognition|positive regulation of synapse assembly|positive regulation of dendritic spine morphogenesis|extracellular exosome|cellular response to organic substance|positive regulation of excitatory postsynaptic potential CUZD1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:50624,Genbank:NM_022034.5,HGNC:HGNC:17937,MIM:616644 CUB and zona pellucida like domains 1 GO:0006931,GO:0007049,GO:0008283,GO:0016021,GO:0030658,GO:0032023,GO:0042589,GO:0051301 substrate-dependent cell migration, cell attachment to substrate|cell cycle|cell proliferation|integral component of membrane|transport vesicle membrane|trypsinogen activation|zymogen granule membrane|cell division CWC15 856.380593184384 875.375713396012 837.385472972757 0.956601217235201 -0.0640104677926333 0.696114412582261 1 12.88 12.1816 11.4837 13.2203 GeneID:51503,Genbank:NM_016403.3,HGNC:HGNC:26939 CWC15 spliceosome associated protein homolog GO:0000398,GO:0003723,GO:0005634,GO:0005681,GO:0005739,GO:0016607,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleus|spliceosomal complex|mitochondrion|nuclear speck|catalytic step 2 spliceosome hsa03040 Spliceosome CWC22 99.556713671915 109.927847515902 89.1855798279277 0.811310162468395 -0.301674535178912 0.307532019130079 1 0.650097 0.877675 0.758134 0.499512 GeneID:57703,Genbank:XM_005246726.3,HGNC:HGNC:29322,MIM:615186 CWC22 spliceosome associated protein homolog GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0005829,GO:0016607,GO:0048024,GO:0071006,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|cytosol|nuclear speck|regulation of mRNA splicing, via spliceosome|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome CWC25 564.914492718043 561.851788008014 567.977197428072 1.01090218016708 0.0156434017754754 0.936443688465386 1 5.3222 5.66099 5.74323 5.52172 GeneID:54883,Genbank:NM_017748.4,HGNC:HGNC:25989 CWC25 spliceosome associated protein homolog GO:0000398,GO:0005654,GO:0016607 mRNA splicing, via spliceosome|nucleoplasm|nuclear speck CWC27 313.975828211687 316.800537722536 311.151118700837 0.982167268205059 -0.0259593509380269 0.939897589805137 1 0.976648 0.837608 1.02204 0.805562 GeneID:10283,Genbank:NM_005869.3,HGNC:HGNC:10664,MIM:617170 CWC27 spliceosome associated protein homolog GO:0000398,GO:0003755,GO:0005634,GO:0005654,GO:0006457,GO:0071013 mRNA splicing, via spliceosome|peptidyl-prolyl cis-trans isomerase activity|nucleus|nucleoplasm|protein folding|catalytic step 2 spliceosome CWF19L1 946.773713041824 967.479710998672 926.067715084976 0.957196005825333 -0.0631137180569256 0.673874130474726 1 11.8326 12.6511 11.5977 12.2392 GeneID:55280,Genbank:NM_001303406.1,HGNC:HGNC:25613,MIM:616120 CWF19 like 1, cell cycle control (S. pombe) CWF19L2 55.4968223132808 56.2131154001871 54.7805292263745 0.974515090230922 -0.0372435692987492 0.952516929004384 1 0.344527 0.47584 0.514563 0.238558 GeneID:143884,Genbank:NM_152434.2,HGNC:HGNC:26508 CWF19 like 2, cell cycle control (S. pombe) CX3CL1 259.980448483553 227.244983680742 292.715913286365 1.28810726003793 0.365252730938492 0.0835285064868522 0.963076417285947 2.75 2.92047 3.75893 3.61616 GeneID:6376,Genbank:NM_002996.5,HGNC:HGNC:10647,MIM:601880 C-X3-C motif chemokine ligand 1 hsa04060,hsa04062,hsa04668,hsa05163 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|TNF signaling pathway|Human cytomegalovirus infection CX3CR1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.010438 0 0 GeneID:1524,Genbank:NM_001171174.1,HGNC:HGNC:2558,MIM:601470 C-X3-C motif chemokine receptor 1 hsa04060,hsa04062 Cytokine-cytokine receptor interaction|Chemokine signaling pathway CXADR 400.524195495439 457.918433173476 343.129957817401 0.749325497642527 -0.41633555133408 0.192916727878066 1 2.3021 1.72743 1.66618 1.35777 GeneID:1525,Genbank:NM_001207066.1,HGNC:HGNC:2559,MIM:602621 CXADR, Ig-like cell adhesion molecule GO:0001618,GO:0001669,GO:0005102,GO:0005178,GO:0005576,GO:0005615,GO:0005654,GO:0005737,GO:0005886,GO:0005887,GO:0005911,GO:0005912,GO:0005913,GO:0005923,GO:0007005,GO:0007157,GO:0007507,GO:0008013,GO:0008354,GO:0010669,GO:0014704,GO:0016323,GO:0016327,GO:0030054,GO:0030165,GO:0030175,GO:0030426,GO:0030593,GO:0031532,GO:0031594,GO:0034109,GO:0042802,GO:0043005,GO:0043234,GO:0044297,GO:0045121,GO:0045216,GO:0046629,GO:0048739,GO:0050776,GO:0050839,GO:0050900,GO:0051607,GO:0070633,GO:0071253,GO:0086067,GO:0086072,GO:0086082,GO:0098904 virus receptor activity|acrosomal vesicle|receptor binding|integrin binding|extracellular region|extracellular space|nucleoplasm|cytoplasm|plasma membrane|integral component of plasma membrane|cell-cell junction|adherens junction|cell-cell adherens junction|bicellular tight junction|mitochondrion organization|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|heart development|beta-catenin binding|germ cell migration|epithelial structure maintenance|intercalated disc|basolateral plasma membrane|apicolateral plasma membrane|cell junction|PDZ domain binding|filopodium|growth cone|neutrophil chemotaxis|actin cytoskeleton reorganization|neuromuscular junction|homotypic cell-cell adhesion|identical protein binding|neuron projection|protein complex|cell body|membrane raft|cell-cell junction organization|gamma-delta T cell activation|cardiac muscle fiber development|regulation of immune response|cell adhesion molecule binding|leukocyte migration|defense response to virus|transepithelial transport|connexin binding|AV node cell to bundle of His cell communication|AV node cell-bundle of His cell adhesion involved in cell communication|cell adhesive protein binding involved in AV node cell-bundle of His cell communication|regulation of AV node cell action potential hsa05416 Viral myocarditis CXCL10 3.17945865384417 0.538097676642304 5.82081963104604 10.8174033892278 3.43528233092293 0.411352985682198 1 0.0391458 0 0.411687 0 GeneID:3627,Genbank:NM_001565.3,HGNC:HGNC:10637,MIM:147310 C-X-C motif chemokine ligand 10 hsa04060,hsa04062,hsa04620,hsa04622,hsa04623,hsa04657,hsa04668,hsa05164,hsa05169 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|Toll-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|IL-17 signaling pathway|TNF signaling pathway|Influenza A|Epstein-Barr virus infection CXCL11 0.780631827935889 1.07619535328461 0.48506830258717 0.450725141217823 -1.14968016979823 0.981241458110389 1 0.056923 0 0.0274671 0 GeneID:6373,Genbank:NM_001302123.1,HGNC:HGNC:10638,MIM:604852 C-X-C motif chemokine ligand 11 hsa04060,hsa04062,hsa04620 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|Toll-like receptor signaling pathway CXCL14 5248.52134843549 4614.44382041981 5882.59887645116 1.27482294841678 0.350296894787778 0.0273302032563385 0.663212932353815 107.859 128.168 145.692 155.149 GeneID:9547,Genbank:NM_004887.4,HGNC:HGNC:10640,MIM:604186 C-X-C motif chemokine ligand 14 hsa04060,hsa04062 Cytokine-cytokine receptor interaction|Chemokine signaling pathway CXCL16 183.600933251501 197.082087823449 170.119778679553 0.863192492825377 -0.212245777108114 0.362841947163195 1 3.16951 3.56235 3.70302 2.76207 GeneID:58191,Genbank:NM_022059.3,HGNC:HGNC:16642,MIM:605398 C-X-C motif chemokine ligand 16 hsa04060,hsa04062 Cytokine-cytokine receptor interaction|Chemokine signaling pathway CXCL2 24.4463572081525 23.2058436805199 25.6868707357851 1.1069138915793 0.146542997166124 0.821198775296894 1 0.954583 0.803422 1.08076 0.565365 GeneID:2920,Genbank:NM_002089.3,HGNC:HGNC:4603,MIM:139110 C-X-C motif chemokine ligand 2 hsa04060,hsa04062,hsa04064,hsa04621,hsa04657,hsa04668,hsa05132,hsa05134,hsa05167 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|NF-kappa B signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Salmonella infection|Legionellosis|Kaposi sarcoma-associated herpesvirus infection CXCL3 28.0549551819917 32.363312838547 23.7465975254364 0.733750516948083 -0.446638480244676 0.418086834334281 1 1.12752 1.2944 0.926168 0.950291 GeneID:2921,Genbank:NM_002090.2,HGNC:HGNC:4604,MIM:139111 C-X-C motif chemokine ligand 3 hsa04060,hsa04062,hsa04621,hsa04657,hsa04668,hsa05132,hsa05134,hsa05167 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Salmonella infection|Legionellosis|Kaposi sarcoma-associated herpesvirus infection CXCL5 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0235416 0 0 GeneID:6374,Genbank:NM_002994.4,HGNC:HGNC:10642,MIM:600324 C-X-C motif chemokine ligand 5 hsa04060,hsa04062,hsa04657,hsa04668,hsa05133,hsa05323 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Pertussis|Rheumatoid arthritis CXCL6 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0347136 GeneID:6372,Genbank:NM_002993.3,HGNC:HGNC:10643,MIM:138965 C-X-C motif chemokine ligand 6 hsa04060,hsa04062,hsa04657,hsa05133,hsa05323 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|IL-17 signaling pathway|Pertussis|Rheumatoid arthritis CXCL8 132.561224523852 146.884099415697 118.238349632007 0.804977190195247 -0.312980191235798 0.243736077115343 1 2.79392 2.78014 2.21282 2.35717 GeneID:3576,Genbank:NM_000584.3,HGNC:HGNC:6025,MIM:146930 C-X-C motif chemokine ligand 8 hsa04060,hsa04062,hsa04064,hsa04072,hsa04218,hsa04620,hsa04621,hsa04622,hsa04657,hsa04932,hsa04933,hsa05120,hsa05131,hsa05132,hsa05133,hsa05134,hsa05142,hsa05144,hsa05146,hsa05160,hsa05161,hsa05163,hsa05164,hsa05167,hsa05200,hsa05202,hsa05219,hsa05323 Cytokine-cytokine receptor interaction|Chemokine signaling pathway|NF-kappa B signaling pathway|Phospholipase D signaling pathway|Cellular senescence|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Chagas disease (American trypanosomiasis)|Malaria|Amoebiasis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Transcriptional misregulation in cancer|Bladder cancer|Rheumatoid arthritis CXCR4 2.04502700037885 2.15239070656922 1.93766329418849 0.900237716263423 -0.151622085900019 1 1 0.0871058 0 0 0.0576854 GeneID:7852,Genbank:NM_003467.2,HGNC:HGNC:2561,MIM:162643 C-X-C motif chemokine receptor 4 GO:0004950,GO:0005764,GO:0005769,GO:0005770,GO:0005886,GO:0006935,GO:0016021,GO:0019955,GO:0030054,GO:0071345 chemokine receptor activity|lysosome|early endosome|late endosome|plasma membrane|chemotaxis|integral component of membrane|cytokine binding|cell junction|cellular response to cytokine stimulus hsa04020,hsa04060,hsa04062,hsa04144,hsa04360,hsa04670,hsa04672,hsa04810,hsa05163,hsa05170,hsa05200 Calcium signaling pathway|Cytokine-cytokine receptor interaction|Chemokine signaling pathway|Endocytosis|Axon guidance|Leukocyte transendothelial migration|Intestinal immune network for IgA production|Regulation of actin cytoskeleton|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer CXCR5 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:643,Genbank:NM_001716.4,HGNC:HGNC:1060,MIM:601613 C-X-C motif chemokine receptor 5 hsa04060,hsa04062 Cytokine-cytokine receptor interaction|Chemokine signaling pathway CXCR6 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0169696 0 GeneID:10663,Genbank:XM_011533290.2,HGNC:HGNC:16647,MIM:605163 C-X-C motif chemokine receptor 6 hsa04060,hsa04062 Cytokine-cytokine receptor interaction|Chemokine signaling pathway CXXC1 466.627103192308 431.226288751172 502.027917633445 1.16418671757539 0.21932246281406 0.242899038125728 1 3.95723 4.04099 4.10876 4.70193 GeneID:30827,Genbank:NM_014593.3,HGNC:HGNC:24343,MIM:609150 CXXC finger protein 1 GO:0000987,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0008270,GO:0016363,GO:0016607,GO:0035097,GO:0036498,GO:0045322,GO:0045893,GO:0048188,GO:0051568 proximal promoter sequence-specific DNA binding|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|nuclear matrix|nuclear speck|histone methyltransferase complex|IRE1-mediated unfolded protein response|unmethylated CpG binding|positive regulation of transcription, DNA-templated|Set1C/COMPASS complex|histone H3-K4 methylation CXXC4 20.2313331931285 18.6511222388488 21.8115441474081 1.16944942336909 0.225829469016189 0.735484181353972 1 0.133251 0.109721 0.182655 0.110956 GeneID:80319,Genbank:NM_025212.3,HGNC:HGNC:24593,MIM:611645 CXXC finger protein 4 GO:0003677,GO:0005737,GO:0007352,GO:0008270,GO:0016055,GO:0030165,GO:0030178,GO:0031410 DNA binding|cytoplasm|zygotic specification of dorsal/ventral axis|zinc ion binding|Wnt signaling pathway|PDZ domain binding|negative regulation of Wnt signaling pathway|cytoplasmic vesicle hsa04310 Wnt signaling pathway CXXC5 2131.42102898615 2029.74308232725 2233.09897564505 1.10018799674126 0.137750068106487 0.331444729616886 1 29.3055 29.7149 32.3103 33.3769 GeneID:51523,Genbank:NM_001317201.1,HGNC:HGNC:26943,MIM:612752 CXXC finger protein 5 GO:0000122,GO:0005654,GO:0005829,GO:0008134,GO:0008270,GO:0043565 negative regulation of transcription from RNA polymerase II promoter|nucleoplasm|cytosol|transcription factor binding|zinc ion binding|sequence-specific DNA binding CXorf38 384.888109521375 414.525643465044 355.250575577707 0.857005063928364 -0.222624365832254 0.22937545796199 1 2.73808 2.95854 2.68762 2.26063 GeneID:159013,Genbank:NM_001330455.1,HGNC:HGNC:28589 chromosome X open reading frame 38 CXorf40A 519.837128305878 498.836524911072 540.837731700685 1.08419833891895 0.116628701710509 0.537935762339164 1 1.54164 1.8747 1.97897 1.88782 GeneID:91966,Genbank:NM_001324275.1,HGNC:HGNC:28089,MIM:300954 chromosome X open reading frame 40A CXorf40B 853.863804093931 868.3618432903 839.365764897562 0.96660829973497 -0.0489967124380138 0.75271335264794 1 3.17546 3.25452 3.16416 3.07505 GeneID:541578,Genbank:XM_011531181.3,HGNC:HGNC:17402 chromosome X open reading frame 40B CXorf56 1138.23134779727 1157.07544062296 1119.38725497159 0.967428065337658 -0.047773703541311 0.774667003268327 1 15.9533 15.0851 13.8918 16.3707 GeneID:63932,Genbank:NM_001170570.1,HGNC:HGNC:26239 chromosome X open reading frame 56 CXorf57 164.67656271066 179.583596177039 149.76952924428 0.833982236866628 -0.261911439103921 0.295136200243352 1 1.72332 1.66875 1.76256 1.1669 GeneID:55086,Genbank:NM_018015.5,HGNC:HGNC:25486 chromosome X open reading frame 57 GO:0003697,GO:0003723,GO:0005657,GO:2000042 single-stranded DNA binding|RNA binding|replication fork|negative regulation of double-strand break repair via homologous recombination CXorf58 1.77978466982289 2.10436443188427 1.45520490776151 0.691517536465156 -0.532162257176787 0.969274875950838 1 0.087144 0 0.0279793 0 GeneID:254158,Genbank:XM_011545473.2,HGNC:HGNC:26356 chromosome X open reading frame 58 CXorf65 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.020894 0.0214709 0.0201388 GeneID:158830,Genbank:XM_005262244.4,HGNC:HGNC:33713 chromosome X open reading frame 65 CYB561 701.659941525853 689.470232269066 713.84965078264 1.03535963899897 0.050131984417369 0.776115061829233 1 7.52023 7.96276 8.28572 8.26722 GeneID:1534,Genbank:NM_001330421.1,HGNC:HGNC:2571,MIM:600019 cytochrome b561 GO:0000293,GO:0005765,GO:0016021,GO:0016491,GO:0022900,GO:0046872,GO:0055114 ferric-chelate reductase activity|lysosomal membrane|integral component of membrane|oxidoreductase activity|electron transport chain|metal ion binding|oxidation-reduction process CYB561A3 1138.04887928558 1036.42487419464 1239.67288437651 1.19610491338294 0.258343937511858 0.087872845725411 0.970228836454666 13.0878 13.3282 16.1551 15.0242 GeneID:220002,Genbank:NM_001300763.1,HGNC:HGNC:23014 cytochrome b561 family member A3 GO:0005765,GO:0016021,GO:0016491,GO:0031902,GO:0046872,GO:0055114 lysosomal membrane|integral component of membrane|oxidoreductase activity|late endosome membrane|metal ion binding|oxidation-reduction process CYB561D1 416.648343280057 366.576098313231 466.720588246882 1.27318881507675 0.348446388112091 0.0554024896439967 0.855410907895938 3.18834 3.07931 4.44886 3.77329 GeneID:284613,Genbank:XM_011541287.3,HGNC:HGNC:26804 cytochrome b561 family member D1 GO:0016021,GO:0046872,GO:0055114 integral component of membrane|metal ion binding|oxidation-reduction process CYB561D2 633.37635821512 613.981653059126 652.771063371113 1.0631768231489 0.088381559865364 0.617542794019483 1 20.7433 22.0157 22.954 24.6452 GeneID:11068,Genbank:NM_007022.4,HGNC:HGNC:30253,MIM:607068 cytochrome b561 family member D2 GO:0016021,GO:0046872,GO:0055114 integral component of membrane|metal ion binding|oxidation-reduction process CYB5A 427.493712820055 447.456479945557 407.530945694553 0.91077225151402 -0.134837757313734 0.525401825009572 1 8.56728 9.57703 7.78535 8.77271 GeneID:1528,Genbank:NM_001190807.2,HGNC:HGNC:2570,MIM:613218 cytochrome b5 type A GO:0004033,GO:0004129,GO:0005741,GO:0005789,GO:0005829,GO:0016020,GO:0016021,GO:0019852,GO:0019899,GO:0020037,GO:0043231,GO:0046686,GO:0046872,GO:0070062 aldo-keto reductase (NADP) activity|cytochrome-c oxidase activity|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|membrane|integral component of membrane|L-ascorbic acid metabolic process|enzyme binding|heme binding|intracellular membrane-bounded organelle|response to cadmium ion|metal ion binding|extracellular exosome CYB5B 4500.39659327404 4594.68976651148 4406.10342003659 0.95895558654484 -0.0604640956557226 0.651361779870788 1 49.4237 51.585 48.1035 49.2883 GeneID:80777,Genbank:NM_030579.2,HGNC:HGNC:24374,MIM:611964 cytochrome b5 type B GO:0005741,GO:0006805,GO:0016020,GO:0016021,GO:0020037,GO:0046872,GO:0055114 mitochondrial outer membrane|xenobiotic metabolic process|membrane|integral component of membrane|heme binding|metal ion binding|oxidation-reduction process CYB5D1 398.306265263747 422.991127467266 373.621403060228 0.883284255386991 -0.179050299320971 0.332180865913462 1 2.28505 2.48196 1.99945 2.2166 GeneID:124637,Genbank:NM_144607.5,HGNC:HGNC:26516 cytochrome b5 domain containing 1 GO:0046872 metal ion binding CYB5D2 600.10009860685 509.127007351321 691.073189862378 1.35736894700914 0.440812913589876 0.00885286898188047 0.366376097193275 5.0512 4.96535 6.50842 6.8851 GeneID:124936,Genbank:XM_017024180.1,HGNC:HGNC:28471 cytochrome b5 domain containing 2 GO:0005576,GO:0012505,GO:0016020,GO:0020037,GO:0045666 extracellular region|endomembrane system|membrane|heme binding|positive regulation of neuron differentiation CYB5R1 1136.5021161561 1034.82918147408 1238.17505083813 1.19650187007135 0.258822651736879 0.0847162234722366 0.964561165794104 22.3931 22.8114 27.3078 27.5664 GeneID:51706,Genbank:NM_016243.2,HGNC:HGNC:13397,MIM:608341 cytochrome b5 reductase 1 GO:0002576,GO:0004128,GO:0005739,GO:0005789,GO:0005886,GO:0015701,GO:0016020,GO:0016021,GO:0016126,GO:0016491,GO:0031092,GO:0070062,GO:1903955 platelet degranulation|cytochrome-b5 reductase activity, acting on NAD(P)H|mitochondrion|endoplasmic reticulum membrane|plasma membrane|bicarbonate transport|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity|platelet alpha granule membrane|extracellular exosome|positive regulation of protein targeting to mitochondrion hsa00520 Amino sugar and nucleotide sugar metabolism CYB5R2 68.1810981197076 63.6602389789174 72.7019572604979 1.14203085672636 0.191601631650572 0.62053387505849 1 0.518478 0.561616 0.592734 0.540245 GeneID:51700,Genbank:NM_001302826.1,HGNC:HGNC:24376,MIM:608342 cytochrome b5 reductase 2 GO:0004128,GO:0005634,GO:0005739,GO:0005789,GO:0015701,GO:0016020,GO:0016126,GO:0055114 cytochrome-b5 reductase activity, acting on NAD(P)H|nucleus|mitochondrion|endoplasmic reticulum membrane|bicarbonate transport|membrane|sterol biosynthetic process|oxidation-reduction process hsa00520 Amino sugar and nucleotide sugar metabolism CYB5R3 5335.51849823365 5155.15286055705 5515.88413591026 1.06997489407409 0.0975769455799323 0.477335186186439 1 50.9274 53.2233 56.6874 58.0893 GeneID:1727,Genbank:NM_000398.6,HGNC:HGNC:2873,MIM:613213 cytochrome b5 reductase 3 hsa00520 Amino sugar and nucleotide sugar metabolism CYB5R4 649.981004979298 693.658326821764 606.303683136832 0.874066755480067 -0.194184627378568 0.250507344324035 1 11.8445 11.1518 11.1685 9.38422 GeneID:51167,Genbank:NM_016230.3,HGNC:HGNC:20147,MIM:608343 cytochrome b5 reductase 4 hsa00520 Amino sugar and nucleotide sugar metabolism CYB5RL 260.249368871159 202.107263356862 318.391474385455 1.57535889159644 0.655680534735542 0.00163948238016899 0.142611020336488 1.76078 1.63254 2.72235 2.83787 GeneID:606495,Genbank:NM_001353353.1,HGNC:HGNC:32220 cytochrome b5 reductase like GO:0004128,GO:0005634,GO:0005654,GO:0005789,GO:0015701,GO:0016491 cytochrome-b5 reductase activity, acting on NAD(P)H|nucleus|nucleoplasm|endoplasmic reticulum membrane|bicarbonate transport|oxidoreductase activity hsa00520 Amino sugar and nucleotide sugar metabolism CYBB 9.14253281934315 6.65908587355536 11.6259797651309 1.74588224057902 0.803956252746223 0.447315000731673 1 0.0488082 0.0565776 0.0471833 0.157649 GeneID:1536,Genbank:NM_000397.3,HGNC:HGNC:2578,MIM:300481 cytochrome b-245 beta chain hsa04066,hsa04145,hsa04216,hsa04217,hsa04621,hsa04670,hsa04933,hsa05140 HIF-1 signaling pathway|Phagosome|Ferroptosis|Necroptosis|NOD-like receptor signaling pathway|Leukocyte transendothelial migration|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis CYBC1 1426.32894246734 1391.04817076301 1461.60971417166 1.05072544926316 0.0713857475771254 0.644503342323095 1 20.4963 21.6608 21.8351 22.5183 GeneID:79415,Genbank:NM_001100408.2,HGNC:HGNC:28672 cytochrome b-245 chaperone 1 GO:0016021 integral component of membrane CYBRD1 1310.84842157195 1263.10131723256 1358.59552591133 1.07560296816727 0.105145641500713 0.615986803814694 1 12.8996 12.8225 16.3316 11.4475 GeneID:79901,Genbank:NM_001256909.1,HGNC:HGNC:20797,MIM:605745 cytochrome b reductase 1 GO:0000293,GO:0005765,GO:0005886,GO:0006879,GO:0010039,GO:0016021,GO:0016722,GO:0031526,GO:0046872,GO:0070062 ferric-chelate reductase activity|lysosomal membrane|plasma membrane|cellular iron ion homeostasis|response to iron ion|integral component of membrane|oxidoreductase activity, oxidizing metal ions|brush border membrane|metal ion binding|extracellular exosome hsa04978 Mineral absorption CYC1 3640.73267946673 3579.50674373955 3701.95861519391 1.03420914674027 0.0485279694567294 0.748808208358238 1 70.4023 76.0063 75.5429 76.946 GeneID:1537,Genbank:NM_001916.4,HGNC:HGNC:2579,MIM:123980 cytochrome c1 hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease CYCS 5930.75028014647 5967.84913342547 5893.65142686747 0.987567094124007 -0.0180493284097138 0.910222008140776 1 48.8555 46.9638 50.0784 46.1885 GeneID:54205,Genbank:NM_018947.5,HGNC:HGNC:19986,MIM:123970 cytochrome c, somatic hsa01524,hsa04115,hsa04210,hsa04215,hsa04932,hsa05010,hsa05012,hsa05014,hsa05016,hsa05134,hsa05145,hsa05152,hsa05161,hsa05163,hsa05164,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05210,hsa05222,hsa05416 Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Amyotrophic lateral sclerosis (ALS)|Huntington disease|Legionellosis|Toxoplasmosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Small cell lung cancer|Viral myocarditis CYFIP1 8080.09874020707 7866.48478110077 8293.71269931338 1.05430988937257 0.076298975277715 0.570396470957362 1 32.2822 34.1888 35.3923 35.8002 GeneID:23191,Genbank:NM_001324119.2,HGNC:HGNC:13759,MIM:606322 cytoplasmic FMR1 interacting protein 1 GO:0000340,GO:0001726,GO:0005576,GO:0005829,GO:0005845,GO:0005925,GO:0006417,GO:0008360,GO:0016601,GO:0030027,GO:0030032,GO:0031209,GO:0031529,GO:0032403,GO:0032433,GO:0032869,GO:0034774,GO:0035580,GO:0038096,GO:0043005,GO:0043025,GO:0043195,GO:0043197,GO:0043312,GO:0044294,GO:0044295,GO:0045773,GO:0048010,GO:0048365,GO:0048471,GO:0048675,GO:0050890,GO:0051015,GO:0051388,GO:0051602,GO:0060076,GO:0070062,GO:0090724,GO:0090725,GO:0097484,GO:0099563,GO:1900006,GO:1900029,GO:1903422,GO:1904724,GO:2000601 RNA 7-methylguanosine cap binding|ruffle|extracellular region|cytosol|mRNA cap binding complex|focal adhesion|regulation of translation|regulation of cell shape|Rac protein signal transduction|lamellipodium|lamellipodium assembly|SCAR complex|ruffle organization|protein complex binding|filopodium tip|cellular response to insulin stimulus|secretory granule lumen|specific granule lumen|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron projection|neuronal cell body|terminal bouton|dendritic spine|neutrophil degranulation|dendritic growth cone|axonal growth cone|positive regulation of axon extension|vascular endothelial growth factor receptor signaling pathway|Rac GTPase binding|perinuclear region of cytoplasm|axon extension|cognition|actin filament binding|positive regulation of neurotrophin TRK receptor signaling pathway|response to electrical stimulus|excitatory synapse|extracellular exosome|central region of growth cone|peripheral region of growth cone|dendrite extension|modification of synaptic structure|positive regulation of dendrite development|positive regulation of ruffle assembly|negative regulation of synaptic vesicle recycling|tertiary granule lumen|positive regulation of Arp2/3 complex-mediated actin nucleation hsa03013,hsa04810 RNA transport|Regulation of actin cytoskeleton CYFIP2 617.801481149924 666.157510383214 569.445451916634 0.85482103412608 -0.22630568682409 0.180139621709341 1 3.07531 2.90348 2.6266 2.51938 GeneID:26999,Genbank:NM_001291722.1,HGNC:HGNC:13760,MIM:606323 cytoplasmic FMR1 interacting protein 2 GO:0005634,GO:0005737,GO:0006915,GO:0030054,GO:0031175,GO:0043005,GO:0045202,GO:0045862,GO:0048471,GO:0051388,GO:0097202,GO:0097484,GO:0098609 nucleus|cytoplasm|apoptotic process|cell junction|neuron projection development|neuron projection|synapse|positive regulation of proteolysis|perinuclear region of cytoplasm|positive regulation of neurotrophin TRK receptor signaling pathway|activation of cysteine-type endopeptidase activity|dendrite extension|cell-cell adhesion hsa03013,hsa04810 RNA transport|Regulation of actin cytoskeleton CYGB 3.42982407374465 2.49838328447175 4.36126486301754 1.74563482317713 0.80375178697801 0.716342598104537 1 0.0121621 0.0211217 0.0224871 0.0421522 GeneID:114757,Genbank:NM_134268.4,HGNC:HGNC:16505,MIM:608759 cytoglobin GO:0001666,GO:0004096,GO:0004601,GO:0005344,GO:0005506,GO:0005829,GO:0006979,GO:0008941,GO:0010764,GO:0015671,GO:0016607,GO:0019395,GO:0019825,GO:0020037,GO:0032966,GO:0043005,GO:0043025,GO:0047888,GO:0050999,GO:2000490 response to hypoxia|catalase activity|peroxidase activity|oxygen carrier activity|iron ion binding|cytosol|response to oxidative stress|nitric oxide dioxygenase activity|negative regulation of fibroblast migration|oxygen transport|nuclear speck|fatty acid oxidation|oxygen binding|heme binding|negative regulation of collagen biosynthetic process|neuron projection|neuronal cell body|fatty acid peroxidase activity|regulation of nitric-oxide synthase activity|negative regulation of hepatic stellate cell activation CYHR1 710.948451938406 683.829506819003 738.067397057809 1.07931493113116 0.110115887335501 0.50656480205408 1 8.96522 8.86799 10.0829 10.4505 GeneID:50626,Genbank:NM_001330618.1,HGNC:HGNC:17806,MIM:616635 cysteine and histidine rich 1 GO:0005654,GO:0008270,GO:0048471 nucleoplasm|zinc ion binding|perinuclear region of cytoplasm CYLD 1035.18854462087 1100.03505289717 970.342036344578 0.882101014680383 -0.180984217977894 0.343142295165325 1 4.26789 4.19149 4.32345 3.09499 GeneID:1540,Genbank:XM_017022979.1,HGNC:HGNC:2584,MIM:605018 CYLD lysine 63 deubiquitinase hsa04217,hsa04380,hsa04622,hsa04625 Necroptosis|Osteoclast differentiation|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway CYP11A1 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0332455 0 GeneID:1583,Genbank:NM_000781.2,HGNC:HGNC:2590,MIM:118485 cytochrome P450 family 11 subfamily A member 1 GO:0005506,GO:0005739,GO:0005743,GO:0005759,GO:0006700,GO:0008203,GO:0008386,GO:0016125,GO:0020037,GO:0042359 iron ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|C21-steroid hormone biosynthetic process|cholesterol metabolic process|cholesterol monooxygenase (side-chain-cleaving) activity|sterol metabolic process|heme binding|vitamin D metabolic process hsa00140,hsa04913,hsa04925,hsa04927,hsa04934 Steroid hormone biosynthesis|Ovarian steroidogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome CYP19A1 4.64369142181757 2.98845468642911 6.29892815720603 2.10775428043468 1.07570668905243 0.503142668883463 1 0 0.0297165 0.0301399 0.0448024 GeneID:1588,Genbank:NM_000103.3,HGNC:HGNC:2594,MIM:107910 cytochrome P450 family 19 subfamily A member 1 hsa00140,hsa04913 Steroid hormone biosynthesis|Ovarian steroidogenesis CYP1A1 3.49166305493517 5.04479284362845 1.93853326624189 0.384264196039337 -1.37982953587636 0.441185271524616 1 0.0317531 0.0570358 0.0298987 0.0139502 GeneID:1543,Genbank:NM_000499.4,HGNC:HGNC:2595,MIM:108330 cytochrome P450 family 1 subfamily A member 1 hsa00140,hsa00380,hsa00830,hsa00980,hsa04913,hsa05204 Steroid hormone biosynthesis|Tryptophan metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Ovarian steroidogenesis|Chemical carcinogenesis CYP1B1 14.0559247984588 9.20549543271206 18.9063541642055 2.05381169350441 1.03830391227873 0.183815161509897 1 0.0829155 0.0980691 0.248238 0.11098 GeneID:1545,Genbank:NM_000104.3,HGNC:HGNC:2597,MIM:601771 cytochrome P450 family 1 subfamily B member 1 hsa00140,hsa00380,hsa00980,hsa04913,hsa05204,hsa05206 Steroid hormone biosynthesis|Tryptophan metabolism|Metabolism of xenobiotics by cytochrome P450|Ovarian steroidogenesis|Chemical carcinogenesis|MicroRNAs in cancer CYP20A1 273.828118124795 287.397270605949 260.258965643641 0.905572154860448 -0.143098496989605 0.500931615024025 1 1.02898 0.991153 0.931808 0.874912 GeneID:57404,Genbank:NM_177538.2,HGNC:HGNC:20576 cytochrome P450 family 20 subfamily A member 1 GO:0004497,GO:0005506,GO:0016020,GO:0016021,GO:0016705,GO:0020037 monooxygenase activity|iron ion binding|membrane|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|heme binding CYP21A2 0.99578132014851 0.538097676642304 1.45346496365472 2.70111733751434 1.43355631240266 0.835241087836065 1 0 0 0.0224571 0.0418668 GeneID:1589,Genbank:NM_000500.7,HGNC:HGNC:2600,MIM:613815 cytochrome P450 family 21 subfamily A member 2 hsa00140,hsa04925,hsa04927,hsa04934 Steroid hormone biosynthesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome CYP24A1 10.0663960001341 11.4059124139662 8.72687958630208 0.765118937404452 -0.386244063335588 0.726266112025665 1 0.126654 0.085892 0.109822 0.0408301 GeneID:1591,Genbank:XM_017027692.2,HGNC:HGNC:2602,MIM:126065 cytochrome P450 family 24 subfamily A member 1 GO:0001649,GO:0005506,GO:0005634,GO:0005654,GO:0005739,GO:0005741,GO:0005886,GO:0006766,GO:0008403,GO:0016491,GO:0020037,GO:0030342,GO:0033280,GO:0042359,GO:0042369,GO:0055114,GO:0070561 osteoblast differentiation|iron ion binding|nucleus|nucleoplasm|mitochondrion|mitochondrial outer membrane|plasma membrane|vitamin metabolic process|25-hydroxycholecalciferol-24-hydroxylase activity|oxidoreductase activity|heme binding|1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|response to vitamin D|vitamin D metabolic process|vitamin D catabolic process|oxidation-reduction process|vitamin D receptor signaling pathway hsa00100,hsa04928,hsa05206 Steroid biosynthesis|Parathyroid hormone synthesis, secretion and action|MicroRNAs in cancer CYP26A1 1.3182945185515 2.15239070656922 0.484198330533773 0.224958381884837 -2.15226997256519 0.648987732022175 1 0.0687895 0 0 0 GeneID:1592,Genbank:NM_057157.2,HGNC:HGNC:2603,MIM:602239 cytochrome P450 family 26 subfamily A member 1 GO:0001972,GO:0005506,GO:0005789,GO:0006766,GO:0006805,GO:0008401,GO:0016125,GO:0016709,GO:0019825,GO:0020037,GO:0031090,GO:0034653,GO:0042573,GO:0048387 retinoic acid binding|iron ion binding|endoplasmic reticulum membrane|vitamin metabolic process|xenobiotic metabolic process|retinoic acid 4-hydroxylase activity|sterol metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|oxygen binding|heme binding|organelle membrane|retinoic acid catabolic process|retinoic acid metabolic process|negative regulation of retinoic acid receptor signaling pathway hsa00830 Retinol metabolism CYP26B1 119.025558414562 132.873942512782 105.177174316343 0.791556059279461 -0.337236566912137 0.234026177617133 1 1.39481 1.15847 1.22406 0.854666 GeneID:56603,Genbank:NM_001277742.1,HGNC:HGNC:20581,MIM:605207 cytochrome P450 family 26 subfamily B member 1 hsa00830 Retinol metabolism CYP27A1 660.251448612416 628.000601616295 692.502295608537 1.10270960541476 0.141052912427232 0.394745905829095 1 12.5607 12.4083 13.3489 14.0983 GeneID:1593,Genbank:XM_017003488.2,HGNC:HGNC:2605,MIM:606530 cytochrome P450 family 27 subfamily A member 1 GO:0005506,GO:0005739,GO:0005743,GO:0005759,GO:0006699,GO:0008395,GO:0016125,GO:0016705,GO:0020037 iron ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|bile acid biosynthetic process|steroid hydroxylase activity|sterol metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|heme binding hsa00120,hsa03320,hsa04979 Primary bile acid biosynthesis|PPAR signaling pathway|Cholesterol metabolism CYP27B1 31.5112939427639 35.3997937996611 27.6227940858668 0.780309462879731 -0.357881699092811 0.493478715572269 1 0.532274 0.52732 0.49474 0.346982 GeneID:1594,Genbank:NM_000785.3,HGNC:HGNC:2606,MIM:609506 cytochrome P450 family 27 subfamily B member 1 hsa00100,hsa04928,hsa05152 Steroid biosynthesis|Parathyroid hormone synthesis, secretion and action|Tuberculosis CYP27C1 130.91697143081 122.25606780399 139.577875057629 1.14168464244581 0.19116420270669 0.476114627154171 1 0.941504 0.812133 1.06063 0.970903 GeneID:339761,Genbank:XM_017003960.1,HGNC:HGNC:33480 cytochrome P450 family 27 subfamily C member 1 hsa00830 Retinol metabolism CYP2C18 2.75992747373762 4.06465003971372 1.45520490776151 0.358014809034827 -1.48190883008156 0.491168597136201 1 0.0151778 0.0719336 0.0289985 0 GeneID:1562,Genbank:NM_000772.2,HGNC:HGNC:2620,MIM:601131 cytochrome P450 family 2 subfamily C member 18 GO:0004497,GO:0005506,GO:0005789,GO:0006805,GO:0008392,GO:0008395,GO:0019373,GO:0019825,GO:0020037,GO:0031090,GO:0070330 monooxygenase activity|iron ion binding|endoplasmic reticulum membrane|xenobiotic metabolic process|arachidonic acid epoxygenase activity|steroid hydroxylase activity|epoxygenase P450 pathway|oxygen binding|heme binding|organelle membrane|aromatase activity hsa00830,hsa04726,hsa05204 Retinol metabolism|Serotonergic synapse|Chemical carcinogenesis CYP2C19 1.26776669418146 1.56626675524197 0.969266633120943 0.61883879605885 -0.692364450254232 0.974556248291384 1 0.0208231 0.00991836 0.00999015 0.00931624 GeneID:1557,Genbank:NM_000769.3,HGNC:HGNC:2621,MIM:124020 cytochrome P450 family 2 subfamily C member 19 hsa00590,hsa00591,hsa00982,hsa04726,hsa05204 Arachidonic acid metabolism|Linoleic acid metabolism|Drug metabolism - cytochrome P450|Serotonergic synapse|Chemical carcinogenesis CYP2C8 27.6941442265392 18.0649982875216 37.3232901655568 2.06605556067713 1.04687905189685 0.0524842158779733 0.838606644358991 0.32611 0.237178 0.679197 0.530519 GeneID:1558,Genbank:NM_000770.3,HGNC:HGNC:2622,MIM:601129 cytochrome P450 family 2 subfamily C member 8 hsa00590,hsa00591,hsa00830,hsa00982,hsa04726,hsa05204 Arachidonic acid metabolism|Linoleic acid metabolism|Retinol metabolism|Drug metabolism - cytochrome P450|Serotonergic synapse|Chemical carcinogenesis CYP2C9 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0.0205351 0 0 0.0182257 GeneID:1559,Genbank:NM_000771.3,HGNC:HGNC:2623,MIM:601130 cytochrome P450 family 2 subfamily C member 9 hsa00590,hsa00591,hsa00830,hsa00980,hsa00982,hsa04726,hsa05204 Arachidonic acid metabolism|Linoleic acid metabolism|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Serotonergic synapse|Chemical carcinogenesis CYP2D6 0.97133319677934 0.490071401957362 1.45259499160132 2.96404765876891 1.56756864484914 0.837512515494886 1 0 0.0300871 0 0.0612285 GeneID:1565,Genbank:NM_001025161.2,HGNC:HGNC:2625,MIM:124030 cytochrome P450 family 2 subfamily D member 6 hsa00980,hsa00982,hsa01522,hsa04726 Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Endocrine resistance|Serotonergic synapse CYP2D7 3.67485977472333 2.98845468642911 4.36126486301754 1.45937125392013 0.545346941553579 0.832865587152448 1 0.020961 0.0540514 0.0384647 0.053783 GeneID:1564,Genbank:NM_001348386.1,HGNC:HGNC:2624 cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) GO:0005506,GO:0005737,GO:0005739,GO:0006805,GO:0008395,GO:0016021,GO:0019369,GO:0020037,GO:0042738,GO:0070330 iron ion binding|cytoplasm|mitochondrion|xenobiotic metabolic process|steroid hydroxylase activity|integral component of membrane|arachidonic acid metabolic process|heme binding|exogenous drug catabolic process|aromatase activity hsa00980,hsa00982,hsa01522,hsa04726 Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Endocrine resistance|Serotonergic synapse CYP2E1 10.7947600595932 11.8959838159236 9.69353630326283 0.814857892651751 -0.295379612773829 0.792717330611971 1 0.285887 0.214814 0.111696 0.124954 GeneID:1571,Genbank:NM_000773.3,HGNC:HGNC:2631,MIM:124040 cytochrome P450 family 2 subfamily E member 1 hsa00140,hsa00590,hsa00591,hsa00980,hsa00982,hsa00983,hsa04932,hsa05204 Steroid hormone biosynthesis|Arachidonic acid metabolism|Linoleic acid metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Non-alcoholic fatty liver disease (NAFLD)|Chemical carcinogenesis CYP2J2 79.6248837958422 72.9519783058914 86.297789285793 1.18293967195711 0.242376500399937 0.729776000079597 1 1.24544 1.14065 2.08903 0.723733 GeneID:1573,Genbank:NM_000775.3,HGNC:HGNC:2634,MIM:601258 cytochrome P450 family 2 subfamily J member 2 hsa00590,hsa00591,hsa04726,hsa04750,hsa04913 Arachidonic acid metabolism|Linoleic acid metabolism|Serotonergic synapse|Inflammatory mediator regulation of TRP channels|Ovarian steroidogenesis CYP2R1 79.5665406493127 79.1690190521743 79.9640622464511 1.01004235247317 0.0144157884443463 0.978846932999182 1 0.301244 0.289641 0.317324 0.279768 GeneID:120227,Genbank:XM_011519898.3,HGNC:HGNC:20580,MIM:608713 cytochrome P450 family 2 subfamily R member 1 GO:0005506,GO:0005789,GO:0006766,GO:0008395,GO:0010164,GO:0010212,GO:0016705,GO:0020037,GO:0030343,GO:0031090,GO:0042359 iron ion binding|endoplasmic reticulum membrane|vitamin metabolic process|steroid hydroxylase activity|response to cesium ion|response to ionizing radiation|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|heme binding|vitamin D3 25-hydroxylase activity|organelle membrane|vitamin D metabolic process hsa00100 Steroid biosynthesis CYP2S1 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0160063 0.0138334 0 0 GeneID:29785,Genbank:NM_030622.7,HGNC:HGNC:15654,MIM:611529 cytochrome P450 family 2 subfamily S member 1 GO:0005506,GO:0005783,GO:0005789,GO:0008392,GO:0008395,GO:0008401,GO:0019373,GO:0020037,GO:0031090,GO:0070330 iron ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|arachidonic acid epoxygenase activity|steroid hydroxylase activity|retinoic acid 4-hydroxylase activity|epoxygenase P450 pathway|heme binding|organelle membrane|aromatase activity hsa00830,hsa00980 Retinol metabolism|Metabolism of xenobiotics by cytochrome P450 CYP2U1 403.386437894391 415.649865093014 391.123010695769 0.94099154972237 -0.0877463275428711 0.632660784249986 1 3.56179 3.88363 3.92832 3.19253 GeneID:113612,Genbank:XM_005262717.2,HGNC:HGNC:20582,MIM:610670 cytochrome P450 family 2 subfamily U member 1 GO:0004497,GO:0005506,GO:0005789,GO:0008395,GO:0016021,GO:0019825,GO:0020037,GO:0031090,GO:0070330,GO:0097267 monooxygenase activity|iron ion binding|endoplasmic reticulum membrane|steroid hydroxylase activity|integral component of membrane|oxygen binding|heme binding|organelle membrane|aromatase activity|omega-hydroxylase P450 pathway hsa00590 Arachidonic acid metabolism CYP2W1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:54905,Genbank:XM_011515441.3,HGNC:HGNC:20243,MIM:615967 cytochrome P450 family 2 subfamily W member 1 CYP39A1 20.9146075136144 19.5352124933937 22.2940025338351 1.14122139912091 0.190578704359799 0.788960325901158 1 0.0985158 0.103797 0.13231 0.0888022 GeneID:51302,Genbank:NM_001278739.1,HGNC:HGNC:17449,MIM:605994 cytochrome P450 family 39 subfamily A member 1 GO:0005506,GO:0005789,GO:0006699,GO:0006707,GO:0007586,GO:0008387,GO:0008396,GO:0016125,GO:0020037,GO:0030573,GO:0031090,GO:0043231 iron ion binding|endoplasmic reticulum membrane|bile acid biosynthetic process|cholesterol catabolic process|digestion|steroid 7-alpha-hydroxylase activity|oxysterol 7-alpha-hydroxylase activity|sterol metabolic process|heme binding|bile acid catabolic process|organelle membrane|intracellular membrane-bounded organelle hsa00120 Primary bile acid biosynthesis CYP3A5 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0 0 GeneID:1577,Genbank:NM_000777.4,HGNC:HGNC:2638,MIM:605325 cytochrome P450 family 3 subfamily A member 5 hsa00140,hsa00830,hsa00980,hsa00982,hsa05204 Steroid hormone biosynthesis|Retinol metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis CYP3A7 0.807146514963456 1.61429302992691 0 0 -Inf 0.549240155942477 1 0.0700724 0.0165182 0.0167578 0 GeneID:1551,Genbank:NM_000765.4,HGNC:HGNC:2640,MIM:605340 cytochrome P450 family 3 subfamily A member 7 hsa00140,hsa00830,hsa05204 Steroid hormone biosynthesis|Retinol metabolism|Chemical carcinogenesis CYP46A1 9.41323573614968 11.0697284911716 7.75674298112774 0.700716642446464 -0.51309693336421 0.598306142699442 1 0.0750121 0.131208 0.138797 0.0324241 GeneID:10858,Genbank:XM_011536364.1,HGNC:HGNC:2641,MIM:604087 cytochrome P450 family 46 subfamily A member 1 GO:0005506,GO:0005783,GO:0005789,GO:0006699,GO:0006707,GO:0006805,GO:0007399,GO:0008395,GO:0016021,GO:0016125,GO:0020037,GO:0031090,GO:0033781 iron ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|bile acid biosynthetic process|cholesterol catabolic process|xenobiotic metabolic process|nervous system development|steroid hydroxylase activity|integral component of membrane|sterol metabolic process|heme binding|organelle membrane|cholesterol 24-hydroxylase activity hsa00120 Primary bile acid biosynthesis CYP4F11 5.37346880583182 2.98845468642911 7.75848292523453 2.59615210512196 1.37637491140971 0.435807577884007 1 0.0124141 0.0336607 0.105256 0.0218161 GeneID:57834,Genbank:NM_001128932.1,HGNC:HGNC:13265,MIM:611517 cytochrome P450 family 4 subfamily F member 11 GO:0004497,GO:0005504,GO:0005506,GO:0005789,GO:0006631,GO:0006954,GO:0007596,GO:0016021,GO:0016709,GO:0020037,GO:0031090,GO:0042361,GO:0042376,GO:0042377,GO:0055114 monooxygenase activity|fatty acid binding|iron ion binding|endoplasmic reticulum membrane|fatty acid metabolic process|inflammatory response|blood coagulation|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|heme binding|organelle membrane|menaquinone catabolic process|phylloquinone catabolic process|vitamin K catabolic process|oxidation-reduction process CYP4V2 137.941263746995 129.511086283981 146.37144121001 1.13018464603917 0.176558494908638 0.514671689883343 1 1.02426 1.15851 1.42421 1.05462 GeneID:285440,Genbank:NM_207352.3,HGNC:HGNC:23198,MIM:608614 cytochrome P450 family 4 subfamily V member 2 CYP51A1 2310.03325572382 2257.48387806164 2362.582633386 1.04655570582174 0.0656491050708064 0.615357785606746 1 31.0431 28.5776 32.8442 30.2989 GeneID:1595,Genbank:NM_001146152.1,HGNC:HGNC:2649,MIM:601637 cytochrome P450 family 51 subfamily A member 1 GO:0005506,GO:0005783,GO:0005789,GO:0005886,GO:0006694,GO:0006695,GO:0008398,GO:0016020,GO:0016021,GO:0016125,GO:0020037,GO:0031090,GO:0033488,GO:0045540 iron ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|steroid biosynthetic process|cholesterol biosynthetic process|sterol 14-demethylase activity|membrane|integral component of membrane|sterol metabolic process|heme binding|organelle membrane|cholesterol biosynthetic process via 24,25-dihydrolanosterol|regulation of cholesterol biosynthetic process hsa00100 Steroid biosynthesis CYR61 9261.17667938667 8523.64546745766 9998.70789131569 1.17305534697444 0.23027108405851 0.0780932943726361 0.94157495521624 166.383 171.35 214.13 188.84 GeneID:3491,Genbank:NM_001554.4,HGNC:HGNC:2654,MIM:602369 cysteine rich angiogenic inducer 61 CYREN 3376.74188430438 3524.3941646537 3229.08960395506 0.916211255920164 -0.126247807996896 0.349325681283765 1 13.3633 13.9169 12.8761 12.2284 GeneID:78996,Genbank:XM_017012595.1,HGNC:HGNC:22432,MIM:616980 cell cycle regulator of NHEJ GO:0005634,GO:0005737,GO:0006303,GO:2001033 nucleus|cytoplasm|double-strand break repair via nonhomologous end joining|negative regulation of double-strand break repair via nonhomologous end joining CYS1 84.3790952327647 81.5233235125912 87.2348669529383 1.07006023790805 0.097692013902179 0.77827203003506 1 1.66031 1.5617 1.9401 1.7345 GeneID:192668,Genbank:NM_001037160.2,HGNC:HGNC:18525 cystin 1 GO:0005829,GO:0005856,GO:0005929,GO:0060170,GO:0070062 cytosol|cytoskeleton|cilium|ciliary membrane|extracellular exosome CYSLTR2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00711789 0 GeneID:57105,Genbank:NM_001308465.2,HGNC:HGNC:18274,MIM:605666 cysteinyl leukotriene receptor 2 GO:0001631,GO:0004974,GO:0005886,GO:0005887,GO:0006955,GO:0007186,GO:0007200,GO:0007218,GO:0008528,GO:0010942,GO:0045766,GO:0070374 cysteinyl leukotriene receptor activity|leukotriene receptor activity|plasma membrane|integral component of plasma membrane|immune response|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|G-protein coupled peptide receptor activity|positive regulation of cell death|positive regulation of angiogenesis|positive regulation of ERK1 and ERK2 cascade hsa04020,hsa04080 Calcium signaling pathway|Neuroactive ligand-receptor interaction CYSRT1 24.9668452651829 19.8812050712962 30.0524854590696 1.51160281035773 0.596079105958055 0.309836236045561 1 0.596483 0.684876 1.08262 0.725783 GeneID:375791,Genbank:NM_199001.3,HGNC:HGNC:30529 cysteine rich tail 1 GO:0070062 extracellular exosome CYSTM1 1729.68635180701 1572.29408624466 1887.07861736935 1.20020715836726 0.263283439629748 0.0676709419388042 0.916343630061028 72.1946 74.1218 87.6784 90.1636 GeneID:84418,Genbank:NM_032412.3,HGNC:HGNC:30239 cysteine rich transmembrane module containing 1 GO:0005886,GO:0016021,GO:0043312,GO:0070062,GO:0070821 plasma membrane|integral component of membrane|neutrophil degranulation|extracellular exosome|tertiary granule membrane CYTH1 913.227514386073 903.655775885484 922.799252886662 1.02118447921436 0.0302435157810501 0.850623853780777 1 5.81161 5.74142 6.51452 5.35065 GeneID:9267,Genbank:NM_017456.3,HGNC:HGNC:9501,MIM:182115 cytohesin 1 GO:0000139,GO:0005086,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005923,GO:0008289,GO:0016192,GO:0030155,GO:0031234,GO:0032012,GO:0090162 Golgi membrane|ARF guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|plasma membrane|adherens junction|bicellular tight junction|lipid binding|vesicle-mediated transport|regulation of cell adhesion|extrinsic component of cytoplasmic side of plasma membrane|regulation of ARF protein signal transduction|establishment of epithelial cell polarity hsa04072,hsa04144 Phospholipase D signaling pathway|Endocytosis CYTH2 2486.03495682153 2396.31038898623 2575.75952465682 1.07488559766521 0.104183118918048 0.46283743269011 1 13.9303 14.1378 15.3727 15.7183 GeneID:9266,Genbank:NM_017457.5,HGNC:HGNC:9502,MIM:602488 cytohesin 2 GO:0005086,GO:0005737,GO:0005886,GO:0008289,GO:0030426,GO:0032012,GO:0070679 ARF guanyl-nucleotide exchange factor activity|cytoplasm|plasma membrane|lipid binding|growth cone|regulation of ARF protein signal transduction|inositol 1,4,5 trisphosphate binding hsa04072,hsa04144 Phospholipase D signaling pathway|Endocytosis CYTH3 3577.97997337248 3419.33963919375 3736.62030755122 1.09279004189016 0.128016242161994 0.350845003300248 1 28.2122 29.7866 34.2488 30.1493 GeneID:9265,Genbank:NM_004227.3,HGNC:HGNC:9504,MIM:605081 cytohesin 3 GO:0000139,GO:0001726,GO:0005086,GO:0005547,GO:0005654,GO:0005829,GO:0005886,GO:0005912,GO:0005923,GO:0031234,GO:0032012,GO:0045785,GO:0048193,GO:0090162 Golgi membrane|ruffle|ARF guanyl-nucleotide exchange factor activity|phosphatidylinositol-3,4,5-trisphosphate binding|nucleoplasm|cytosol|plasma membrane|adherens junction|bicellular tight junction|extrinsic component of cytoplasmic side of plasma membrane|regulation of ARF protein signal transduction|positive regulation of cell adhesion|Golgi vesicle transport|establishment of epithelial cell polarity hsa04072,hsa04144 Phospholipase D signaling pathway|Endocytosis CYTH4 1.4647761204752 1.96028560782945 0.969266633120943 0.49445174175113 -1.01609837336455 0.813651560116793 1 0 0.0398081 0.0105086 0.00985506 GeneID:27128,Genbank:NM_001318024.1,HGNC:HGNC:9505,MIM:606514 cytohesin 4 GO:0000139,GO:0005086,GO:0005829,GO:0005886,GO:0008289,GO:0032012 Golgi membrane|ARF guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|lipid binding|regulation of ARF protein signal transduction hsa04072,hsa04144 Phospholipase D signaling pathway|Endocytosis D2HGDH 225.746813051893 215.003007286916 236.490618816869 1.0999409812965 0.137426116227096 0.544687683524152 1 1.3048 1.33194 1.36867 1.3076 GeneID:728294,Genbank:NM_152783.4,HGNC:HGNC:28358,MIM:609186 D-2-hydroxyglutarate dehydrogenase GO:0004458,GO:0005739,GO:0005759,GO:0006103,GO:0010042,GO:0010043,GO:0019516,GO:0022904,GO:0032025,GO:0044267,GO:0051990,GO:0071949 D-lactate dehydrogenase (cytochrome) activity|mitochondrion|mitochondrial matrix|2-oxoglutarate metabolic process|response to manganese ion|response to zinc ion|lactate oxidation|respiratory electron transport chain|response to cobalt ion|cellular protein metabolic process|(R)-2-hydroxyglutarate dehydrogenase activity|FAD binding DAAM1 74.7042183269426 74.758376434558 74.6500602193271 0.998551116003359 -0.00209181352054902 1 1 0.42917 0.356909 0.542246 0.309304 GeneID:23002,Genbank:XM_005267431.1,HGNC:HGNC:18142,MIM:606626 dishevelled associated activator of morphogenesis 1 GO:0001725,GO:0003779,GO:0005829,GO:0005886,GO:0016020,GO:0017048,GO:0030036,GO:0031514,GO:0036064,GO:0042802,GO:0060071 stress fiber|actin binding|cytosol|plasma membrane|membrane|Rho GTPase binding|actin cytoskeleton organization|motile cilium|ciliary basal body|identical protein binding|Wnt signaling pathway, planar cell polarity pathway hsa04310 Wnt signaling pathway DAAM2 54.7731362537666 58.1734010080165 51.3728714995168 0.883098986982683 -0.179352935580982 0.645704581087819 1 0.137523 0.178159 0.151408 0.129824 GeneID:23500,Genbank:XM_006715043.2,HGNC:HGNC:18143,MIM:606627 dishevelled associated activator of morphogenesis 2 GO:0003779,GO:0007368,GO:0017048,GO:0030036,GO:0070062 actin binding|determination of left/right symmetry|Rho GTPase binding|actin cytoskeleton organization|extracellular exosome hsa04310 Wnt signaling pathway DAB1 57.4468015404112 40.2426728894418 74.6509301913806 1.85501918315585 0.891434106145657 0.0848060227712368 0.964561165794104 0.150802 0.152359 0.487107 0.211387 GeneID:1600,Genbank:NM_021080.4,HGNC:HGNC:2661,MIM:603448 DAB1, reelin adaptor protein GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding DAB2 658.777617216577 643.835756957239 673.719477475915 1.04641513024984 0.0654553062110607 0.740712428051526 1 5.40888 5.06398 6.48565 4.65036 GeneID:1601,Genbank:NM_001244871.1,HGNC:HGNC:2662,MIM:601236 DAB2, clathrin adaptor protein hsa04144 Endocytosis DAB2IP 803.746352713166 814.118822153051 793.373883273281 0.974518536710763 -0.0372384670580226 0.808576816266055 1 2.75961 2.75921 2.97143 2.51088 GeneID:153090,Genbank:XM_005251721.1,HGNC:HGNC:17294,MIM:609205 DAB2 interacting protein hsa04210,hsa04668 Apoptosis|TNF signaling pathway DACH1 421.58123908756 355.054516039679 488.107962135441 1.37474089213075 0.45915972855471 0.1584499203978 1 1.35982 1.19961 2.11327 1.37105 GeneID:1602,Genbank:XM_011534939.2,HGNC:HGNC:2663,MIM:603803 dachshund family transcription factor 1 GO:0001075,GO:0001078,GO:0001967,GO:0003677,GO:0005634,GO:0005667,GO:0005737,GO:0007275,GO:0007585,GO:0008283,GO:0010944,GO:0030336,GO:0033262,GO:0045892,GO:0046545,GO:0048147,GO:0060244,GO:2000279 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|suckling behavior|DNA binding|nucleus|transcription factor complex|cytoplasm|multicellular organism development|respiratory gaseous exchange|cell proliferation|negative regulation of transcription by competitive promoter binding|negative regulation of cell migration|regulation of nuclear cell cycle DNA replication|negative regulation of transcription, DNA-templated|development of primary female sexual characteristics|negative regulation of fibroblast proliferation|negative regulation of cell proliferation involved in contact inhibition|negative regulation of DNA biosynthetic process DACT1 542.047309863819 538.386195643854 545.708424083785 1.01360032723568 0.0194888953581542 0.911579299831849 1 5.42373 5.32852 5.84897 5.25891 GeneID:51339,Genbank:NM_016651.5,HGNC:HGNC:17748,MIM:607861 dishevelled binding antagonist of beta catenin 1 DACT3 39.7307236667681 35.8418389269335 43.6196084066026 1.21700252309946 0.283332159061756 0.549937737279322 1 0.381643 0.449538 0.519957 0.439501 GeneID:147906,Genbank:NM_001301046.1,HGNC:HGNC:30745,MIM:611112 dishevelled binding antagonist of beta catenin 3 GO:0005080,GO:0005737,GO:0008013,GO:0010719,GO:0016055,GO:0030178,GO:0030308,GO:0035414,GO:0042802,GO:0051018,GO:0070097,GO:0090090 protein kinase C binding|cytoplasm|beta-catenin binding|negative regulation of epithelial to mesenchymal transition|Wnt signaling pathway|negative regulation of Wnt signaling pathway|negative regulation of cell growth|negative regulation of catenin import into nucleus|identical protein binding|protein kinase A binding|delta-catenin binding|negative regulation of canonical Wnt signaling pathway DAD1 2085.17935277829 2025.03447340642 2145.32423215016 1.05940133875419 0.0832492368674546 0.560470458918585 1 169.005 180.509 178.696 194.548 GeneID:1603,Genbank:NM_001344.3,HGNC:HGNC:2664,MIM:600243 defender against cell death 1 GO:0001824,GO:0004579,GO:0006486,GO:0006487,GO:0006915,GO:0007584,GO:0008250,GO:0016020,GO:0016021,GO:0042493,GO:0043066,GO:0070062 blastocyst development|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein glycosylation|protein N-linked glycosylation|apoptotic process|response to nutrient|oligosaccharyltransferase complex|membrane|integral component of membrane|response to drug|negative regulation of apoptotic process|extracellular exosome hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum DAG1 12463.8646521284 11020.1039272326 13907.6253770242 1.2620230688257 0.335738281933975 0.0100386265618437 0.399946873170368 65.0835 66.8684 88.5534 81.4079 GeneID:1605,Genbank:NM_001177643.2,HGNC:HGNC:2666,MIM:128239 dystroglycan 1 hsa04512,hsa05410,hsa05412,hsa05414,hsa05416 ECM-receptor interaction|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Viral myocarditis DAGLA 270.049577462364 301.177104790548 238.922050134179 0.793294199106987 -0.334072095440267 0.103571056721946 1 1.93047 1.84157 1.56223 1.5169 GeneID:747,Genbank:XM_017018238.1,HGNC:HGNC:1165,MIM:614015 diacylglycerol lipase alpha GO:0005886,GO:0007216,GO:0007405,GO:0016021,GO:0019369,GO:0042136,GO:0043196,GO:0045211,GO:0046340,GO:0046872,GO:0047372,GO:0071926,GO:0098921 plasma membrane|G-protein coupled glutamate receptor signaling pathway|neuroblast proliferation|integral component of membrane|arachidonic acid metabolic process|neurotransmitter biosynthetic process|varicosity|postsynaptic membrane|diacylglycerol catabolic process|metal ion binding|acylglycerol lipase activity|endocannabinoid signaling pathway|retrograde trans-synaptic signaling by endocannabinoid hsa04723,hsa04925 Retrograde endocannabinoid signaling|Aldosterone synthesis and secretion DAGLB 786.35041350303 748.835498489953 823.865328516107 1.10019534354001 0.137759702055199 0.405510065108504 1 9.59595 10.9755 11.53 10.922 GeneID:221955,Genbank:NM_001142936.1,HGNC:HGNC:28923,MIM:614016 diacylglycerol lipase beta GO:0005634,GO:0005765,GO:0005886,GO:0007405,GO:0016021,GO:0016042,GO:0019369,GO:0042136,GO:0046872,GO:0047372 nucleus|lysosomal membrane|plasma membrane|neuroblast proliferation|integral component of membrane|lipid catabolic process|arachidonic acid metabolic process|neurotransmitter biosynthetic process|metal ion binding|acylglycerol lipase activity hsa04723,hsa04925 Retrograde endocannabinoid signaling|Aldosterone synthesis and secretion DALRD3 807.685466342691 814.340353217114 801.030579468268 0.9836557605229 -0.0237745755392599 0.867103019069354 1 11.9642 12.6056 11.48 12.9577 GeneID:55152,Genbank:XM_017006723.1,HGNC:HGNC:25536 DALR anticodon binding domain containing 3 GO:0004814,GO:0005524,GO:0006420 arginine-tRNA ligase activity|ATP binding|arginyl-tRNA aminoacylation DAND5 6.84367341704503 7.38928864893743 6.29805818515264 0.85232266384103 -0.230528399883456 0.940815835591187 1 0.294444 0.0784521 0.054755 0.229786 GeneID:199699,Genbank:NM_152654.2,HGNC:HGNC:26780,MIM:609068 DAN domain BMP antagonist family member 5 GO:0003140,GO:0003281,GO:0003283,GO:0005576,GO:0005615,GO:0016015,GO:0023019,GO:0030512,GO:0030514,GO:0035582,GO:0038101,GO:0061371,GO:1900108,GO:1900176 determination of left/right asymmetry in lateral mesoderm|ventricular septum development|atrial septum development|extracellular region|extracellular space|morphogen activity|signal transduction involved in regulation of gene expression|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|sequestering of BMP in extracellular matrix|sequestering of nodal from receptor via nodal binding|determination of heart left/right asymmetry|negative regulation of nodal signaling pathway|negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry DAP 5922.01748570904 5351.91838176792 6492.11658965015 1.21304476760454 0.278632794324273 0.0373940447991747 0.744556882325193 82.8153 92.2707 110.573 103.966 GeneID:1611,Genbank:NM_001291963.1,HGNC:HGNC:2672,MIM:600954 death associated protein GO:0006914,GO:0006915,GO:0006919,GO:0010507,GO:0032088,GO:0034198,GO:0045892,GO:0070513,GO:0097190 autophagy|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of autophagy|negative regulation of NF-kappaB transcription factor activity|cellular response to amino acid starvation|negative regulation of transcription, DNA-templated|death domain binding|apoptotic signaling pathway DAP3 2961.40027032226 3126.18393927645 2796.61660136807 0.894578391959669 -0.160720183615183 0.240931028084142 1 42.5058 42.5285 36.5281 40.019 GeneID:7818,Genbank:XM_024449697.1,HGNC:HGNC:2673,MIM:602074 death associated protein 3 GO:0003723,GO:0003735,GO:0005525,GO:0005654,GO:0005739,GO:0005743,GO:0005763,GO:0070125,GO:0070126,GO:0097190 RNA binding|structural constituent of ribosome|GTP binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination|apoptotic signaling pathway DAPK1 181.230395297569 174.914221876637 187.546568718502 1.07222023861944 0.100601271961323 0.706138706374077 1 0.67866 0.902654 0.823407 0.826867 GeneID:1612,Genbank:NM_001288731.1,HGNC:HGNC:2674,MIM:600831 death associated protein kinase 1 hsa04140,hsa05200,hsa05219 Autophagy - animal|Pathways in cancer|Bladder cancer DAPK2 666.930430016732 768.33249336377 565.528366669694 0.736046401205555 -0.442131376595528 0.0100968404936149 0.401267983488181 1.68728 2.05492 1.14434 1.32463 GeneID:23604,Genbank:NM_014326.3,HGNC:HGNC:2675,MIM:616567 death associated protein kinase 2 GO:0004674,GO:0005516,GO:0005524,GO:0005737,GO:0005794,GO:0006468,GO:0006915,GO:0010506,GO:0018105,GO:0018107,GO:0031410,GO:0034423,GO:0035556,GO:0042802,GO:0042981,GO:0043231,GO:0043276,GO:0046777,GO:0090023,GO:1990266,GO:2000424,GO:2001242 protein serine/threonine kinase activity|calmodulin binding|ATP binding|cytoplasm|Golgi apparatus|protein phosphorylation|apoptotic process|regulation of autophagy|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|cytoplasmic vesicle|autophagosome lumen|intracellular signal transduction|identical protein binding|regulation of apoptotic process|intracellular membrane-bounded organelle|anoikis|protein autophosphorylation|positive regulation of neutrophil chemotaxis|neutrophil migration|positive regulation of eosinophil chemotaxis|regulation of intrinsic apoptotic signaling pathway hsa04140,hsa05200,hsa05219 Autophagy - animal|Pathways in cancer|Bladder cancer DAPK3 2463.76076126806 2439.93655241554 2487.58497012058 1.01952854784599 0.0279021728623205 0.86504113560525 1 44.6463 46.6843 48.2409 46.4604 GeneID:1613,Genbank:NM_001348.2,HGNC:HGNC:2676,MIM:603289 death associated protein kinase 3 GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005884,GO:0006351,GO:0006355,GO:0006468,GO:0006915,GO:0006940,GO:0007088,GO:0007346,GO:0008022,GO:0008140,GO:0008360,GO:0010506,GO:0016569,GO:0016605,GO:0017048,GO:0017148,GO:0018105,GO:0018107,GO:0030182,GO:0030335,GO:0035556,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043519,GO:0043522,GO:0045121,GO:0046777,GO:0051893,GO:0071346,GO:0090263,GO:0097190,GO:2000145,GO:2000249,GO:2001241 protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|actin filament|transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|regulation of smooth muscle contraction|regulation of mitotic nuclear division|regulation of mitotic cell cycle|protein C-terminus binding|cAMP response element binding protein binding|regulation of cell shape|regulation of autophagy|covalent chromatin modification|PML body|Rho GTPase binding|negative regulation of translation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|neuron differentiation|positive regulation of cell migration|intracellular signal transduction|identical protein binding|protein homodimerization activity|regulation of apoptotic process|positive regulation of apoptotic process|regulation of myosin II filament organization|leucine zipper domain binding|membrane raft|protein autophosphorylation|regulation of focal adhesion assembly|cellular response to interferon-gamma|positive regulation of canonical Wnt signaling pathway|apoptotic signaling pathway|regulation of cell motility|regulation of actin cytoskeleton reorganization|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa04140,hsa05200,hsa05219 Autophagy - animal|Pathways in cancer|Bladder cancer DAPL1 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0934705 0.086697 0 0 GeneID:92196,Genbank:NM_001017920.2,HGNC:HGNC:21490 death associated protein like 1 GO:0010507,GO:0030154,GO:0034198,GO:0070513,GO:0097190 negative regulation of autophagy|cell differentiation|cellular response to amino acid starvation|death domain binding|apoptotic signaling pathway DARS 1153.79474221775 1212.8258765848 1094.76360785069 0.902655219505569 -0.147753057451449 0.339288410958803 1 15.4501 13.9264 13.6235 12.9829 GeneID:1615,Genbank:NM_001293312.1,HGNC:HGNC:2678,MIM:603084 aspartyl-tRNA synthetase GO:0003723,GO:0004046,GO:0004815,GO:0005524,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006422,GO:0006461,GO:0016020,GO:0017101,GO:0070062 RNA binding|aminoacylase activity|aspartate-tRNA ligase activity|ATP binding|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|aspartyl-tRNA aminoacylation|protein complex assembly|membrane|aminoacyl-tRNA synthetase multienzyme complex|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis DARS2 1123.63864339063 1082.20139432882 1165.07589245244 1.07657955215907 0.106454929133505 0.474692311895783 1 9.80982 9.87915 11.3288 9.79889 GeneID:55157,Genbank:XM_006711427.4,HGNC:HGNC:25538,MIM:610956 aspartyl-tRNA synthetase 2, mitochondrial GO:0000049,GO:0004815,GO:0005524,GO:0005634,GO:0005739,GO:0005759,GO:0006418,GO:0042803,GO:0043039,GO:0050560,GO:0070145 tRNA binding|aspartate-tRNA ligase activity|ATP binding|nucleus|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|protein homodimerization activity|tRNA aminoacylation|aspartate-tRNA(Asn) ligase activity|mitochondrial asparaginyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis DAW1 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0394815 0 GeneID:164781,Genbank:NM_001330004.1,HGNC:HGNC:26383 dynein assembly factor with WD repeats 1 GO:0005737,GO:0005929,GO:0007368,GO:0007507 cytoplasm|cilium|determination of left/right symmetry|heart development DAXX 2125.33406334953 2219.19575012834 2031.47237657071 0.915409276740563 -0.127511182630029 0.353870525121978 1 23.5806 25.0761 22.1673 23.1547 GeneID:1616,Genbank:NM_001254717.1,HGNC:HGNC:2681,MIM:603186 death domain associated protein hsa04010,hsa04210,hsa05014,hsa05168 MAPK signaling pathway|Apoptosis|Amyotrophic lateral sclerosis (ALS)|Herpes simplex infection DAZAP1 4900.25183699799 4902.41435531942 4898.08931867657 0.99911777415588 -0.00127334462164807 0.975749453868676 1 32.6836 34.2398 34.5831 33.8874 GeneID:26528,Genbank:NM_170711.2,HGNC:HGNC:2683,MIM:607430 DAZ associated protein 1 GO:0001893,GO:0003723,GO:0005654,GO:0005829,GO:0007283,GO:0008266,GO:0008283,GO:0030154,GO:0034046,GO:0035613,GO:0043234,GO:0048026,GO:1990904 maternal placenta development|RNA binding|nucleoplasm|cytosol|spermatogenesis|poly(U) RNA binding|cell proliferation|cell differentiation|poly(G) binding|RNA stem-loop binding|protein complex|positive regulation of mRNA splicing, via spliceosome|ribonucleoprotein complex hsa03015 mRNA surveillance pathway DAZAP2 5079.17420388998 5300.82039244539 4857.52801533457 0.916372873575836 -0.125993342199436 0.345787143150305 1 78.2509 78.0754 75.6448 68.9606 GeneID:9802,Genbank:NM_001136269.1,HGNC:HGNC:2684,MIM:607431 DAZ associated protein 2 GO:0005737,GO:0016607,GO:0042802,GO:0043234,GO:0050699 cytoplasm|nuclear speck|identical protein binding|protein complex|WW domain binding DBF4 650.507987792346 748.967734657191 552.048240927501 0.737078802440239 -0.440109226160998 0.0270487373071349 0.658377776156645 6.69766 5.86291 5.27405 3.98911 GeneID:10926,Genbank:NM_006716.3,HGNC:HGNC:17364,MIM:604281 DBF4 zinc finger GO:0000082,GO:0003676,GO:0005634,GO:0005654,GO:0006260,GO:0008047,GO:0008270,GO:0016604 G1/S transition of mitotic cell cycle|nucleic acid binding|nucleus|nucleoplasm|DNA replication|enzyme activator activity|zinc ion binding|nuclear body hsa04110 Cell cycle DBF4B 1068.98785667359 1086.32489629918 1051.65081704801 0.968081299278611 -0.0467998850518067 0.744512040679869 1 5.48831 5.70974 5.60285 5.45162 GeneID:80174,Genbank:XM_017025147.1,HGNC:HGNC:17883,MIM:611661 DBF4 zinc finger B GO:0003676,GO:0005634,GO:0005654,GO:0005737,GO:0007049,GO:0008270,GO:0008284,GO:0010571,GO:0010971,GO:0016235,GO:0019901,GO:0030295,GO:0043231 nucleic acid binding|nucleus|nucleoplasm|cytoplasm|cell cycle|zinc ion binding|positive regulation of cell proliferation|positive regulation of nuclear cell cycle DNA replication|positive regulation of G2/M transition of mitotic cell cycle|aggresome|protein kinase binding|protein kinase activator activity|intracellular membrane-bounded organelle DBI 3999.85809337446 4024.59402556531 3975.1221611836 0.98770761372018 -0.017844063871993 0.893293213037821 1 91.3867 88.1693 84.1397 98.5318 GeneID:1622,Genbank:NM_001282633.1,HGNC:HGNC:2690,MIM:125950 diazepam binding inhibitor, acyl-CoA binding protein GO:0005788,GO:0005794,GO:0006637,GO:0008289,GO:0030156,GO:0036042,GO:0036151,GO:0046983,GO:0070062,GO:0097038 endoplasmic reticulum lumen|Golgi apparatus|acyl-CoA metabolic process|lipid binding|benzodiazepine receptor binding|long-chain fatty acyl-CoA binding|phosphatidylcholine acyl-chain remodeling|protein dimerization activity|extracellular exosome|perinuclear endoplasmic reticulum hsa03320 PPAR signaling pathway DBN1 3077.13326703983 3124.21587901522 3030.05065506444 0.969859565536662 -0.044152232919072 0.812246335707627 1 22.4646 22.7169 19.9808 24.9947 GeneID:1627,Genbank:XM_011534447.2,HGNC:HGNC:2695,MIM:126660 drebrin 1 GO:0003779,GO:0005522,GO:0005737,GO:0005856,GO:0005886,GO:0005921,GO:0007015,GO:0010643,GO:0010644,GO:0015629,GO:0030425,GO:0030426,GO:0030863,GO:0032507,GO:0042641,GO:0045296,GO:0048168,GO:0048699,GO:0050773,GO:0061351 actin binding|profilin binding|cytoplasm|cytoskeleton|plasma membrane|gap junction|actin filament organization|cell communication by chemical coupling|cell communication by electrical coupling|actin cytoskeleton|dendrite|growth cone|cortical cytoskeleton|maintenance of protein location in cell|actomyosin|cadherin binding|regulation of neuronal synaptic plasticity|generation of neurons|regulation of dendrite development|neural precursor cell proliferation DBNDD1 1081.07422015623 977.751593129561 1184.39684718291 1.21134739693128 0.276612668464445 0.0683157123963473 0.917906417567028 13.7924 13.7185 16.984 17.6094 GeneID:79007,Genbank:NM_001288709.1,HGNC:HGNC:28455 dysbindin domain containing 1 GO:0030672,GO:0031175 synaptic vesicle membrane|neuron projection development DBNDD2 525.656701850335 557.518597630407 493.794806070264 0.885701047765967 -0.175108269341286 0.299627220169314 1 7.22472 7.77378 6.17629 6.80292 GeneID:55861,Genbank:NM_001197139.1,HGNC:HGNC:15881,MIM:611453 dysbindin domain containing 2 GO:0006469,GO:0030672,GO:0031175 negative regulation of protein kinase activity|synaptic vesicle membrane|neuron projection development DBNL 3577.54025505629 3338.74843221039 3816.33207790218 1.14304271657137 0.192879319417781 0.157363099056422 1 44.6929 45.1653 52.6803 53.7221 GeneID:28988,Genbank:NM_001122956.1,HGNC:HGNC:2696,MIM:610106 drebrin like GO:0000139,GO:0001726,GO:0002102,GO:0002250,GO:0003779,GO:0005576,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0005938,GO:0006898,GO:0007257,GO:0007416,GO:0008022,GO:0008047,GO:0014069,GO:0016601,GO:0019904,GO:0030027,GO:0030054,GO:0030425,GO:0030665,GO:0034774,GO:0043312,GO:0045296,GO:0048812,GO:0051015,GO:0070062,GO:0071800,GO:0097178,GO:1904724,GO:1904813 Golgi membrane|ruffle|podosome|adaptive immune response|actin binding|extracellular region|cytoplasm|early endosome|cytosol|plasma membrane|cell cortex|receptor-mediated endocytosis|activation of JUN kinase activity|synapse assembly|protein C-terminus binding|enzyme activator activity|postsynaptic density|Rac protein signal transduction|protein domain specific binding|lamellipodium|cell junction|dendrite|clathrin-coated vesicle membrane|secretory granule lumen|neutrophil degranulation|cadherin binding|neuron projection morphogenesis|actin filament binding|extracellular exosome|podosome assembly|ruffle assembly|tertiary granule lumen|ficolin-1-rich granule lumen DBP 245.377204811067 247.962252731898 242.792156890236 0.979149665787023 -0.0303986981985986 0.878122094982138 1 6.15331 6.57941 6.18287 6.39345 GeneID:1628,Genbank:NM_001352.4,HGNC:HGNC:2697,MIM:124097 D-box binding PAR bZIP transcription factor GO:0000977,GO:0001077,GO:0001889,GO:0005634,GO:0006357,GO:0007275,GO:0007623,GO:0045944 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|liver development|nucleus|regulation of transcription from RNA polymerase II promoter|multicellular organism development|circadian rhythm|positive regulation of transcription from RNA polymerase II promoter DBR1 411.832396463859 418.522649919857 405.14214300786 0.968029192889418 -0.0468775393278505 0.810943046886216 1 6.07198 6.14654 6.09872 5.84748 GeneID:51163,Genbank:NM_016216.3,HGNC:HGNC:15594,MIM:607024 debranching RNA lariats 1 GO:0000375,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0008419,GO:0046872 RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|RNA lariat debranching enzyme activity|metal ion binding DBT 225.495031267184 209.612221865385 241.377840668984 1.15154468819093 0.203570399129416 0.367324599967737 1 0.676309 0.721886 0.972776 0.669022 GeneID:1629,Genbank:NM_001918.3,HGNC:HGNC:2698,MIM:248610 dihydrolipoamide branched chain transacylase E2 GO:0005739,GO:0005759,GO:0005947,GO:0009083,GO:0031625,GO:0034641,GO:0042645,GO:0043754 mitochondrion|mitochondrial matrix|mitochondrial alpha-ketoglutarate dehydrogenase complex|branched-chain amino acid catabolic process|ubiquitin protein ligase binding|cellular nitrogen compound metabolic process|mitochondrial nucleoid|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity hsa00280,hsa00640 Valine, leucine and isoleucine degradation|Propanoate metabolism DCAF1 1700.60207791791 1794.13745884791 1607.06669698791 0.895732202157952 -0.158860621942341 0.265595773726201 1 6.01301 6.16078 5.85122 5.18415 GeneID:9730,Genbank:XM_017007549.2,HGNC:HGNC:30911,MIM:617259 DDB1 and CUL4 associated factor 1 GO:0000122,GO:0001650,GO:0005524,GO:0005634,GO:0005737,GO:0006351,GO:0016032,GO:0016567,GO:0030183,GO:0030331,GO:0033151,GO:0035212,GO:0080008,GO:1990244,GO:1990245 negative regulation of transcription from RNA polymerase II promoter|fibrillar center|ATP binding|nucleus|cytoplasm|transcription, DNA-templated|viral process|protein ubiquitination|B cell differentiation|estrogen receptor binding|V(D)J recombination|cell competition in a multicellular organism|Cul4-RING E3 ubiquitin ligase complex|histone kinase activity (H2A-T120 specific)|histone H2A-T120 phosphorylation hsa05170 Human immunodeficiency virus 1 infection DCAF10 308.981526820228 305.827878781589 312.135174858866 1.02062367924862 0.0294510188498463 0.898862320866224 1 1.4606 1.60455 1.81562 1.32072 GeneID:79269,Genbank:NM_001286810.1,HGNC:HGNC:23686 DDB1 and CUL4 associated factor 10 GO:0005654,GO:0016567,GO:0043687,GO:0080008 nucleoplasm|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF11 2260.36514901234 2205.70610759356 2315.02419043113 1.04956149074495 0.0697866923985684 0.641456529228731 1 16.8078 18.8249 19.0372 19.1705 GeneID:80344,Genbank:NM_001163484.1,HGNC:HGNC:20258,MIM:613317 DDB1 and CUL4 associated factor 11 GO:0005654,GO:0016567,GO:0043687,GO:0080008 nucleoplasm|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF12 2406.45737182349 2485.20134983583 2327.71339381115 0.936629699627722 -0.0944493096516908 0.501012822500536 1 25.7459 25.5008 25.7941 23.5689 GeneID:25853,Genbank:NM_015397.3,HGNC:HGNC:19911 DDB1 and CUL4 associated factor 12 GO:0005737,GO:0005813,GO:0016567,GO:0080008 cytoplasm|centrosome|protein ubiquitination|Cul4-RING E3 ubiquitin ligase complex DCAF12L2 1.73045343705785 2.00831188251439 1.45259499160132 0.723291538654186 -0.467350820334915 0.969065272483004 1 0.0235142 0.0620887 0 0.061493 GeneID:340578,Genbank:NM_001013628.2,HGNC:HGNC:32950 DDB1 and CUL4 associated factor 12 like 2 DCAF13 735.4801506038 838.504688389624 632.455612817976 0.754266042367191 -0.406854618732537 0.0164430794845008 0.534055811244943 13.5443 11.2829 10.0594 8.79973 GeneID:25879,Genbank:NM_015420.6,HGNC:HGNC:24535,MIM:616196 DDB1 and CUL4 associated factor 13 GO:0000462,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005813,GO:0005829,GO:0006364,GO:0016567,GO:0030054,GO:0030331,GO:0032040,GO:0043687,GO:0080008 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleoplasm|nucleolus|centrosome|cytosol|rRNA processing|protein ubiquitination|cell junction|estrogen receptor binding|small-subunit processome|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF15 1145.95087958746 1161.26658617822 1130.6351729967 0.973622410610873 -0.0385657188395567 0.775263254174319 1 20.9271 21.9902 21.736 20.4378 GeneID:90379,Genbank:NM_138353.3,HGNC:HGNC:25095 DDB1 and CUL4 associated factor 15 GO:0016567,GO:0043234,GO:0080008 protein ubiquitination|protein complex|Cul4-RING E3 ubiquitin ligase complex DCAF16 931.279222055172 929.089428510872 933.469015599473 1.00471384880099 0.00678466787306362 0.943896721381715 1 7.05238 6.28715 7.323 5.85283 GeneID:54876,Genbank:XM_024454104.1,HGNC:HGNC:25987 DDB1 and CUL4 associated factor 16 GO:0005654,GO:0016567,GO:0043687,GO:0080008 nucleoplasm|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF17 153.597173829617 153.053113887295 154.141233771939 1.00710942663633 0.0102204466899637 0.980917806643518 1 0.580763 0.594912 0.831596 0.488177 GeneID:80067,Genbank:XM_017004998.1,HGNC:HGNC:25784,MIM:612515 DDB1 and CUL4 associated factor 17 GO:0005654,GO:0005730,GO:0005829,GO:0016021,GO:0016567,GO:0043687,GO:0080008 nucleoplasm|nucleolus|cytosol|integral component of membrane|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF4 144.731401364658 146.499889218218 142.962913511099 0.975856802854979 -0.0352586325169625 0.898317647819073 1 1.03267 1.06367 1.07052 0.940904 GeneID:26094,Genbank:NM_001352448.1,HGNC:HGNC:20229,MIM:616372 DDB1 and CUL4 associated factor 4 GO:0003723,GO:0005654,GO:0005682,GO:0008380,GO:0016567,GO:0043687,GO:0071011,GO:0071013,GO:0080008 RNA binding|nucleoplasm|U5 snRNP|RNA splicing|protein ubiquitination|post-translational protein modification|precatalytic spliceosome|catalytic step 2 spliceosome|Cul4-RING E3 ubiquitin ligase complex DCAF4L1 2.96920389452665 2.54640955915669 3.3919982298966 1.33207096152276 0.413670939098415 0.922290344647737 1 0.0187147 0.0270017 0.0270453 0.0335139 GeneID:285429,Genbank:NM_001029955.3,HGNC:HGNC:27723 DDB1 and CUL4 associated factor 4 like 1 DCAF5 952.239875783046 921.182676496363 983.297075069728 1.06742896947391 0.0941400709725018 0.54300982846307 1 3.46436 3.43172 3.82136 3.72605 GeneID:8816,Genbank:NM_001284206.1,HGNC:HGNC:20224,MIM:603812 DDB1 and CUL4 associated factor 5 GO:0005654,GO:0005739,GO:0016567,GO:0043687,GO:0080008 nucleoplasm|mitochondrion|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF6 1200.84669474635 1114.37158506777 1287.32180442494 1.1551997750792 0.208142366440779 0.295088576450552 1 7.75976 7.14025 9.92422 7.34444 GeneID:55827,Genbank:NM_001349774.1,HGNC:HGNC:30002,MIM:610494 DDB1 and CUL4 associated factor 6 GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0016567,GO:0030374,GO:0043687,GO:0045944,GO:0080008 nucleus|nucleoplasm|cytosol|focal adhesion|protein ubiquitination|ligand-dependent nuclear receptor transcription coactivator activity|post-translational protein modification|positive regulation of transcription from RNA polymerase II promoter|Cul4-RING E3 ubiquitin ligase complex DCAF7 5837.47902096407 5479.29262665213 6195.66541527601 1.13074183794078 0.177269582168878 0.182854406810493 1 34.604 36.1523 42.8869 38.4798 GeneID:10238,Genbank:NM_005828.4,HGNC:HGNC:30915,MIM:605973 DDB1 and CUL4 associated factor 7 GO:0005654,GO:0005737,GO:0005829,GO:0007275,GO:0016363,GO:0016567,GO:0016604,GO:0043234,GO:0043687,GO:0080008 nucleoplasm|cytoplasm|cytosol|multicellular organism development|nuclear matrix|protein ubiquitination|nuclear body|protein complex|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAF8 2473.06995269783 2381.46213410175 2564.67777129391 1.07693409631359 0.106929965916752 0.436037415016099 1 18.4845 18.2018 20.6417 19.234 GeneID:50717,Genbank:NM_015726.3,HGNC:HGNC:24891,MIM:615820 DDB1 and CUL4 associated factor 8 GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0016567,GO:0043687,GO:0080008 nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|protein ubiquitination|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DCAKD 737.128705544655 698.85802414541 775.3993869439 1.10952347995444 0.149940198454618 0.357777128266117 1 6.90567 7.05629 7.93028 8.12327 GeneID:79877,Genbank:NM_001321326.1,HGNC:HGNC:26238 dephospho-CoA kinase domain containing GO:0004140,GO:0005524,GO:0005739,GO:0015937,GO:0016020 dephospho-CoA kinase activity|ATP binding|mitochondrion|coenzyme A biosynthetic process|membrane DCBLD1 534.190160536315 559.017220800748 509.363100271883 0.911176044885095 -0.134198276265141 0.431013592280942 1 4.39638 4.69317 4.46944 3.944 GeneID:285761,Genbank:XM_017010775.2,HGNC:HGNC:21479 discoidin, CUB and LCCL domain containing 1 GO:0016021,GO:0070492 integral component of membrane|oligosaccharide binding DCBLD2 9288.27400443682 8641.13574705844 9935.4122618152 1.14978083352033 0.201358886798447 0.24016292387088 1 58.5701 54.5432 75.1698 57.283 GeneID:131566,Genbank:NM_080927.3,HGNC:HGNC:24627,MIM:608698 discoidin, CUB and LCCL domain containing 2 GO:0005887,GO:0009986,GO:0030308,GO:0030522,GO:0042060 integral component of plasma membrane|cell surface|negative regulation of cell growth|intracellular receptor signaling pathway|wound healing DCC 1.02523254288787 1.56626675524197 0.484198330533773 0.309141676482158 -1.69365993276169 0.789571303159055 1 0.00746502 0.00352185 0 0.00332423 GeneID:1630,Genbank:NM_005215.3,HGNC:HGNC:2701,MIM:120470 DCC netrin 1 receptor hsa04360,hsa05200,hsa05210 Axon guidance|Pathways in cancer|Colorectal cancer DCDC1 1.48335117242078 1.02816907859967 1.93853326624189 1.88542264749112 0.914887962799843 0.868258168018795 1 0.00222762 0.00215448 0.00215212 0.00200143 GeneID:341019,Genbank:NM_020869.3,HGNC:HGNC:20625,MIM:608062 doublecortin domain containing 1 GO:0005622,GO:0035556 intracellular|intracellular signal transduction DCDC2 2.74774634486374 2.10436443188427 3.3911282578432 1.61147385237202 0.688380779549015 0.791592663219117 1 0.0264927 0.00856572 0.00854578 0.0238321 GeneID:51473,Genbank:NM_001195610.1,HGNC:HGNC:18141,MIM:605755 doublecortin domain containing 2 GO:0001764,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005929,GO:0005930,GO:0006968,GO:0007605,GO:0015630,GO:0019894,GO:0030111,GO:0035556,GO:0045880,GO:0060091,GO:0060271,GO:0072686,GO:1902017 neuron migration|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|cilium|axoneme|cellular defense response|sensory perception of sound|microtubule cytoskeleton|kinesin binding|regulation of Wnt signaling pathway|intracellular signal transduction|positive regulation of smoothened signaling pathway|kinocilium|cilium assembly|mitotic spindle|regulation of cilium assembly DCDC2B 1.29177983152393 1.61429302992691 0.969266633120943 0.600427936658332 -0.735936990778882 0.974657200381333 1 0 0 0 0 GeneID:149069,Genbank:XM_017000413.1,HGNC:HGNC:32576 doublecortin domain containing 2B GO:0005622,GO:0035556 intracellular|intracellular signal transduction DCHS1 19.0574570243782 22.1198396721274 15.9950743766291 0.723109869407599 -0.467713227784258 0.689738191046018 1 0.130899 0.0336982 0.0765814 0.0527891 GeneID:8642,Genbank:NM_003737.3,HGNC:HGNC:13681,MIM:603057 dachsous cadherin-related 1 GO:0001658,GO:0003192,GO:0003273,GO:0005509,GO:0005622,GO:0005886,GO:0007156,GO:0007157,GO:0007389,GO:0016020,GO:0016021,GO:0016339,GO:0021915,GO:0022008,GO:0035329,GO:0036342,GO:0043931,GO:0045177,GO:0048565,GO:0072137,GO:0072659,GO:0090102 branching involved in ureteric bud morphogenesis|mitral valve formation|cell migration involved in endocardial cushion formation|calcium ion binding|intracellular|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|pattern specification process|membrane|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|neural tube development|neurogenesis|hippo signaling|post-anal tail morphogenesis|ossification involved in bone maturation|apical part of cell|digestive tract development|condensed mesenchymal cell proliferation|protein localization to plasma membrane|cochlea development hsa04392 Hippo signaling pathway - multiple species DCHS2 30.4306388426109 31.7771888872198 29.0840887980021 0.915250524557859 -0.127761399504982 0.831172038929682 1 0.07718 0.0808623 0.0884315 0.0630636 GeneID:54798,Genbank:NM_001358235.1,HGNC:HGNC:23111,MIM:612486 dachsous cadherin-related 2 GO:0005509,GO:0005886,GO:0007156,GO:0016021,GO:0072006,GO:0072137 calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|nephron development|condensed mesenchymal cell proliferation hsa04392 Hippo signaling pathway - multiple species DCK 1346.91963469334 1450.24668984706 1243.59257953961 0.857504166874364 -0.221784413089521 0.136940054552836 1 30.1866 29.2448 27.177 24.2064 GeneID:1633,Genbank:NM_000788.2,HGNC:HGNC:2704,MIM:125450 deoxycytidine kinase GO:0004137,GO:0005524,GO:0005634,GO:0005829,GO:0006220,GO:0008144,GO:0019206,GO:0042803,GO:0043097,GO:0043101 deoxycytidine kinase activity|ATP binding|nucleus|cytosol|pyrimidine nucleotide metabolic process|drug binding|nucleoside kinase activity|protein homodimerization activity|pyrimidine nucleoside salvage|purine-containing compound salvage hsa00230,hsa00240 Purine metabolism|Pyrimidine metabolism DCLK1 565.840758322783 595.62748012264 536.054036522925 0.899982043159847 -0.152031878448031 0.371809158190951 1 1.67525 1.77177 1.83318 1.38885 GeneID:9201,Genbank:NM_001330072.1,HGNC:HGNC:2700,MIM:604742 doublecortin like kinase 1 GO:0001764,GO:0004672,GO:0004674,GO:0005524,GO:0005622,GO:0006468,GO:0007409,GO:0007420,GO:0009615,GO:0014069,GO:0018105,GO:0018107,GO:0021952,GO:0030424,GO:0030426,GO:0030900,GO:0035556,GO:0048675,GO:0048812,GO:0048813,GO:1900181 neuron migration|protein kinase activity|protein serine/threonine kinase activity|ATP binding|intracellular|protein phosphorylation|axonogenesis|brain development|response to virus|postsynaptic density|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|central nervous system projection neuron axonogenesis|axon|growth cone|forebrain development|intracellular signal transduction|axon extension|neuron projection morphogenesis|dendrite morphogenesis|negative regulation of protein localization to nucleus DCLK2 267.291798211447 258.339996067265 276.243600355629 1.06930248726838 0.0966700243882584 0.661404509678911 1 1.8012 2.01404 2.23983 1.99587 GeneID:166614,Genbank:NM_001040261.4,HGNC:HGNC:19002,MIM:613166 doublecortin like kinase 2 GO:0000226,GO:0004674,GO:0005524,GO:0005737,GO:0005874,GO:0015630,GO:0018105,GO:0018107,GO:0021766,GO:0021860,GO:0030182,GO:0035556,GO:1900181 microtubule cytoskeleton organization|protein serine/threonine kinase activity|ATP binding|cytoplasm|microtubule|microtubule cytoskeleton|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|hippocampus development|pyramidal neuron development|neuron differentiation|intracellular signal transduction|negative regulation of protein localization to nucleus DCLK3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:85443,Genbank:XM_011534167.2,HGNC:HGNC:19005,MIM:613167 doublecortin like kinase 3 GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0018105,GO:0018107,GO:0035556,GO:1900181 protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|intracellular signal transduction|negative regulation of protein localization to nucleus DCLRE1A 317.732476000314 333.510991663772 301.953960336856 0.905379336466578 -0.143405714651714 0.48457381099313 1 2.77998 2.50962 2.76051 2.10491 GeneID:9937,Genbank:NM_001271816.1,HGNC:HGNC:17660,MIM:609682 DNA cross-link repair 1A DCLRE1B 737.614887530842 739.033053449951 736.196721611732 0.996162104218508 -0.00554756552304518 0.980456459964019 1 7.5206 7.47921 8.36115 6.90369 GeneID:64858,Genbank:NM_001319947.1,HGNC:HGNC:17641,MIM:609683 DNA cross-link repair 1B DCLRE1C 186.465969363823 190.691542287788 182.240396439859 0.955681590559613 -0.065398066887506 0.812759142674058 1 0.66389 0.586154 0.677153 0.48957 GeneID:64421,Genbank:NM_001350966.1,HGNC:HGNC:17642,MIM:605988 DNA cross-link repair 1C hsa03450,hsa05340 Non-homologous end-joining|Primary immunodeficiency DCN 1.97342257437814 2.00831188251439 1.93853326624189 0.965255089670065 -0.0510178385486115 1 1 0.00833542 0.0242383 0.0161116 0.00748226 GeneID:1634,Genbank:NM_001920.4,HGNC:HGNC:2705,MIM:125255 decorin hsa04350,hsa05205 TGF-beta signaling pathway|Proteoglycans in cancer DCP1A 561.155065057888 660.939212750207 461.370917365569 0.698053479753119 -0.518590525473907 0.00258649093813573 0.184112172734141 4.36748 3.8629 2.98794 2.86314 GeneID:55802,Genbank:NM_001290207.1,HGNC:HGNC:18714,MIM:607010 decapping mRNA 1A GO:0000184,GO:0000290,GO:0000932,GO:0003729,GO:0005634,GO:0005737,GO:0005829,GO:0008047,GO:0016020,GO:0016787,GO:0019894,GO:0030234,GO:0031087,GO:0036464,GO:0042802,GO:0043488,GO:0043928,GO:1903608 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|mRNA binding|nucleus|cytoplasm|cytosol|enzyme activator activity|membrane|hydrolase activity|kinesin binding|enzyme regulator activity|deadenylation-independent decapping of nuclear-transcribed mRNA|cytoplasmic ribonucleoprotein granule|identical protein binding|regulation of mRNA stability|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|protein localization to cytoplasmic stress granule hsa03018 RNA degradation DCP1B 118.392532445932 113.684722597291 123.100342294573 1.08282220761215 0.114796381216843 0.680320242165878 1 0.879894 1.01449 1.07735 0.941551 GeneID:196513,Genbank:NM_152640.4,HGNC:HGNC:24451,MIM:609843 decapping mRNA 1B GO:0000184,GO:0000290,GO:0000932,GO:0003729,GO:0005634,GO:0005829,GO:0008047,GO:0016020,GO:0016787,GO:0030234,GO:0031087,GO:0043231,GO:0043928 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|mRNA binding|nucleus|cytosol|enzyme activator activity|membrane|hydrolase activity|enzyme regulator activity|deadenylation-independent decapping of nuclear-transcribed mRNA|intracellular membrane-bounded organelle|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay hsa03018 RNA degradation DCP2 363.589684482497 367.056361060081 360.123007904913 0.981110930389154 -0.0275118293149195 0.907237143667804 1 1.65514 1.6025 1.84847 1.30141 GeneID:167227,Genbank:NM_152624.5,HGNC:HGNC:24452,MIM:609844 decapping mRNA 2 GO:0000184,GO:0000932,GO:0003723,GO:0005634,GO:0006402,GO:0030145,GO:0050072,GO:0071044 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|P-body|RNA binding|nucleus|mRNA catabolic process|manganese ion binding|m7G(5')pppN diphosphatase activity|histone mRNA catabolic process hsa03018 RNA degradation DCPS 1086.78938626053 1090.44636426783 1083.13240825324 0.993292695308769 -0.00970919299594146 0.951318774980223 1 6.43082 6.22657 6.55778 6.38147 GeneID:28960,Genbank:NM_001350236.1,HGNC:HGNC:29812,MIM:610534 decapping enzyme, scavenger GO:0000288,GO:0000290,GO:0000340,GO:0000932,GO:0004532,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0036245,GO:0043069,GO:0043928,GO:0045292,GO:0050072 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|deadenylation-dependent decapping of nuclear-transcribed mRNA|RNA 7-methylguanosine cap binding|P-body|exoribonuclease activity|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|cellular response to menadione|negative regulation of programmed cell death|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|mRNA cis splicing, via spliceosome|m7G(5')pppN diphosphatase activity hsa03018 RNA degradation DCST1 3.89218419706944 2.45035700978681 5.33401138435208 2.17683029984931 1.12222894307569 0.609974673901494 1 0 0.0771281 0.102054 0 GeneID:149095,Genbank:NM_152494.3,HGNC:HGNC:26539 DC-STAMP domain containing 1 GO:0005886,GO:0016021,GO:0042787,GO:0045087,GO:0046872,GO:0060339,GO:0061630 plasma membrane|integral component of membrane|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|innate immune response|metal ion binding|negative regulation of type I interferon-mediated signaling pathway|ubiquitin protein ligase activity DCST2 2.19401015198765 2.45035700978681 1.93766329418849 0.790767747903426 -0.338674064094209 0.964358256709538 1 0 0.0409828 0 0.0271015 GeneID:127579,Genbank:XM_011509188.2,HGNC:HGNC:26562 DC-STAMP domain containing 2 GO:0016021 integral component of membrane DCT 2.0003722474324 2.54640955915669 1.45433493570811 0.571131588191866 -0.808104915392946 0.825102646268534 1 0.0151099 0.0071819 0.00726755 0.00675691 GeneID:1638,Genbank:NM_001322182.1,HGNC:HGNC:2709,MIM:191275 dopachrome tautomerase GO:0002052,GO:0004167,GO:0005507,GO:0005829,GO:0006583,GO:0008544,GO:0016021,GO:0016491,GO:0021847,GO:0033162,GO:0042438,GO:0042470,GO:0048066,GO:0048468 positive regulation of neuroblast proliferation|dopachrome isomerase activity|copper ion binding|cytosol|melanin biosynthetic process from tyrosine|epidermis development|integral component of membrane|oxidoreductase activity|ventricular zone neuroblast division|melanosome membrane|melanin biosynthetic process|melanosome|developmental pigmentation|cell development hsa00350,hsa04916 Tyrosine metabolism|Melanogenesis DCTD 1835.13772719013 1805.94719876957 1864.32825561069 1.03232711171229 0.0459001874943157 0.750518633829233 1 24.3941 24.5858 25.7437 25.9128 GeneID:1635,Genbank:NM_001921.2,HGNC:HGNC:2710,MIM:607638 dCMP deaminase GO:0004132,GO:0005737,GO:0005829,GO:0006220,GO:0006226,GO:0006231,GO:0008270,GO:0015949,GO:0042802,GO:0070062 dCMP deaminase activity|cytoplasm|cytosol|pyrimidine nucleotide metabolic process|dUMP biosynthetic process|dTMP biosynthetic process|zinc ion binding|nucleobase-containing small molecule interconversion|identical protein binding|extracellular exosome hsa00240 Pyrimidine metabolism DCTN1 4411.20179920522 4225.83884997955 4596.56474843088 1.08772835680971 0.121318310986512 0.372866058841008 1 25.657 26.4949 28.9667 29.7067 GeneID:1639,Genbank:NM_001190836.1,HGNC:HGNC:2711,MIM:601143 dynactin subunit 1 GO:0000086,GO:0000132,GO:0000278,GO:0000776,GO:0000922,GO:0003774,GO:0005635,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005869,GO:0005874,GO:0005938,GO:0006888,GO:0007399,GO:0008017,GO:0010389,GO:0010457,GO:0010970,GO:0015631,GO:0016020,GO:0019886,GO:0019901,GO:0030286,GO:0031116,GO:0031252,GO:0032402,GO:0034454,GO:0035371,GO:0036498,GO:0042147,GO:0045111,GO:0051081,GO:0051301,GO:0060236,GO:0070840,GO:0090063,GO:0097711,GO:0099738,GO:0120103,GO:1905515 G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|mitotic cell cycle|kinetochore|spindle pole|motor activity|nuclear envelope|cytoplasm|centrosome|centriole|spindle|cytosol|dynactin complex|microtubule|cell cortex|ER to Golgi vesicle-mediated transport|nervous system development|microtubule binding|regulation of G2/M transition of mitotic cell cycle|centriole-centriole cohesion|transport along microtubule|tubulin binding|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|dynein complex|positive regulation of microtubule polymerization|cell leading edge|melanosome transport|microtubule anchoring at centrosome|microtubule plus-end|IRE1-mediated unfolded protein response|retrograde transport, endosome to Golgi|intermediate filament cytoskeleton|nuclear envelope disassembly|cell division|regulation of mitotic spindle organization|dynein complex binding|positive regulation of microtubule nucleation|ciliary basal body-plasma membrane docking|cell cortex region|centriolar subdistal appendage|non-motile cilium assembly hsa04962,hsa05016 Vasopressin-regulated water reabsorption|Huntington disease DCTN2 3077.28078546338 2878.65697401928 3275.90459690749 1.13799755457962 0.186497457469053 0.176769260082865 1 26.1661 27.5217 29.5041 31.657 GeneID:10540,Genbank:NM_001261413.1,HGNC:HGNC:2712,MIM:607376 dynactin subunit 2 GO:0000086,GO:0000278,GO:0000776,GO:0003774,GO:0005737,GO:0005813,GO:0005829,GO:0005869,GO:0005874,GO:0006888,GO:0007052,GO:0008283,GO:0010389,GO:0016020,GO:0019886,GO:0019901,GO:0030286,GO:0030426,GO:0030507,GO:0031982,GO:0032402,GO:0042802,GO:0070062,GO:0071539,GO:0097711 G2/M transition of mitotic cell cycle|mitotic cell cycle|kinetochore|motor activity|cytoplasm|centrosome|cytosol|dynactin complex|microtubule|ER to Golgi vesicle-mediated transport|mitotic spindle organization|cell proliferation|regulation of G2/M transition of mitotic cell cycle|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|dynein complex|growth cone|spectrin binding|vesicle|melanosome transport|identical protein binding|extracellular exosome|protein localization to centrosome|ciliary basal body-plasma membrane docking hsa04962,hsa05016 Vasopressin-regulated water reabsorption|Huntington disease DCTN3 1784.63700870708 1732.26705169001 1837.00696572414 1.06046406870808 0.0846957394211764 0.740176682603368 1 48.3749 53.9988 50.0242 63.4649 GeneID:11258,Genbank:NM_001281425.1,HGNC:HGNC:2713,MIM:607387 dynactin subunit 3 GO:0000086,GO:0000278,GO:0000777,GO:0000910,GO:0005198,GO:0005730,GO:0005813,GO:0005819,GO:0005829,GO:0005869,GO:0005874,GO:0006888,GO:0007017,GO:0010389,GO:0019886,GO:0030496,GO:0032154,GO:0048471,GO:0097711 G2/M transition of mitotic cell cycle|mitotic cell cycle|condensed chromosome kinetochore|cytokinesis|structural molecule activity|nucleolus|centrosome|spindle|cytosol|dynactin complex|microtubule|ER to Golgi vesicle-mediated transport|microtubule-based process|regulation of G2/M transition of mitotic cell cycle|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|cleavage furrow|perinuclear region of cytoplasm|ciliary basal body-plasma membrane docking DCTN4 1852.57668673951 1796.99062636454 1908.16274711448 1.06186572101094 0.0866013406431713 0.544191982176576 1 13.7901 13.7416 16.5622 12.9523 GeneID:51164,Genbank:NM_016221.3,HGNC:HGNC:15518,MIM:614758 dynactin subunit 4 GO:0000776,GO:0000922,GO:0001725,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005868,GO:0005869,GO:0005925,GO:0006888,GO:0007097,GO:0019886,GO:0047485 kinetochore|spindle pole|stress fiber|nucleus|cytoplasm|centrosome|cytosol|cytoplasmic dynein complex|dynactin complex|focal adhesion|ER to Golgi vesicle-mediated transport|nuclear migration|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein N-terminus binding hsa04962,hsa05016 Vasopressin-regulated water reabsorption|Huntington disease DCTN5 2412.42703346582 2389.49639863266 2435.35766829899 1.01919285992336 0.0274270757707812 0.849632823601914 1 10.5212 11.2918 12.1557 10.5953 GeneID:84516,Genbank:NM_001199743.1,HGNC:HGNC:24594,MIM:612962 dynactin subunit 5 GO:0000777,GO:0003281,GO:0005654,GO:0005813,GO:0005829,GO:0006888,GO:0019886,GO:0031965,GO:0035904,GO:0060976 condensed chromosome kinetochore|ventricular septum development|nucleoplasm|centrosome|cytosol|ER to Golgi vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|nuclear membrane|aorta development|coronary vasculature development hsa04962 Vasopressin-regulated water reabsorption DCTN6 684.778555157458 726.473493442692 643.083616872224 0.885212774694241 -0.175903823758553 0.290991065835228 1 26.5785 24.9081 22.4109 22.7237 GeneID:10671,Genbank:NM_006571.3,HGNC:HGNC:16964,MIM:612963 dynactin subunit 6 GO:0000777,GO:0005813,GO:0005829,GO:0005869,GO:0006888,GO:0019886 condensed chromosome kinetochore|centrosome|cytosol|dynactin complex|ER to Golgi vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II hsa04962 Vasopressin-regulated water reabsorption DCTPP1 1530.41670602733 1683.58730376281 1377.24610829184 0.818042583959678 -0.289752148947262 0.0413270418968017 0.759924113684472 69.8217 77.2477 59.2866 63.8635 GeneID:79077,Genbank:NM_024096.1,HGNC:HGNC:28777,MIM:615840 dCTP pyrophosphatase 1 GO:0000287,GO:0005634,GO:0005739,GO:0005829,GO:0006253,GO:0009143,GO:0032556,GO:0042262,GO:0042802,GO:0047429,GO:0047840,GO:0051289 magnesium ion binding|nucleus|mitochondrion|cytosol|dCTP catabolic process|nucleoside triphosphate catabolic process|pyrimidine deoxyribonucleotide binding|DNA protection|identical protein binding|nucleoside-triphosphate diphosphatase activity|dCTP diphosphatase activity|protein homotetramerization hsa00240 Pyrimidine metabolism DCUN1D1 451.866135146154 485.458484232458 418.273786059849 0.861605677200528 -0.214900338921137 0.368247193180819 1 1.34242 1.21467 1.53026 1.09253 GeneID:54165,Genbank:XM_011512915.2,HGNC:HGNC:18184,MIM:605905 defective in cullin neddylation 1 domain containing 1 GO:0000151,GO:0005634,GO:0005829,GO:0031624,GO:0032182,GO:0043687,GO:0045116,GO:0051443,GO:0097602 ubiquitin ligase complex|nucleus|cytosol|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|post-translational protein modification|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding DCUN1D2 364.361216114434 401.101610513456 327.620821715413 0.816802558573676 -0.291940709528929 0.12256682732492 1 1.82515 1.94587 1.65052 1.4373 GeneID:55208,Genbank:XM_017020647.1,HGNC:HGNC:20328 defective in cullin neddylation 1 domain containing 2 GO:0000151,GO:0031624,GO:0032182,GO:0045116,GO:0051443,GO:0097602 ubiquitin ligase complex|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding DCUN1D3 215.02126423509 202.270959491133 227.771568979048 1.12607153074306 0.171298473750787 0.452613636713755 1 1.38732 1.53164 1.65605 1.66224 GeneID:123879,Genbank:NM_173475.3,HGNC:HGNC:28734,MIM:616167 defective in cullin neddylation 1 domain containing 3 GO:0000151,GO:0005886,GO:0010225,GO:0010332,GO:0030308,GO:0031624,GO:0032182,GO:0043065,GO:0043687,GO:0045116,GO:0048471,GO:0051443,GO:0097602,GO:2000134 ubiquitin ligase complex|plasma membrane|response to UV-C|response to gamma radiation|negative regulation of cell growth|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|positive regulation of apoptotic process|post-translational protein modification|protein neddylation|perinuclear region of cytoplasm|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding|negative regulation of G1/S transition of mitotic cell cycle DCUN1D4 293.038377714742 315.148027073032 270.928728356452 0.859687210714052 -0.218116250927331 0.293120333232617 1 2.17539 1.85351 1.9895 1.51055 GeneID:23142,Genbank:NM_001287757.1,HGNC:HGNC:28998,MIM:612977 defective in cullin neddylation 1 domain containing 4 GO:0000151,GO:0005634,GO:0031624,GO:0032182,GO:0045116,GO:0051443,GO:0097602 ubiquitin ligase complex|nucleus|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding DCUN1D5 847.892122071388 898.101294329682 797.682949813094 0.888188175264197 -0.171062730519131 0.280349602259054 1 1.98672 2.09034 1.75513 1.85948 GeneID:84259,Genbank:NM_001318740.1,HGNC:HGNC:28409,MIM:616522 defective in cullin neddylation 1 domain containing 5 GO:0000151,GO:0031624,GO:0032182,GO:0045116,GO:0051443,GO:0097602 ubiquitin ligase complex|ubiquitin conjugating enzyme binding|ubiquitin-like protein binding|protein neddylation|positive regulation of ubiquitin-protein transferase activity|cullin family protein binding DCX 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00439147 0 0 GeneID:1641,Genbank:NM_178153.2,HGNC:HGNC:2714,MIM:300121 doublecortin GO:0001764,GO:0005829,GO:0005856,GO:0005874,GO:0005875,GO:0007399,GO:0007417,GO:0008017,GO:0019901,GO:0035556,GO:0043005 neuron migration|cytosol|cytoskeleton|microtubule|microtubule associated complex|nervous system development|central nervous system development|microtubule binding|protein kinase binding|intracellular signal transduction|neuron projection DCXR 1415.03074674491 1443.11140923008 1386.95008425974 0.961083167514907 -0.0572668145962545 0.711653949937195 1 55.8337 64.4967 56.7472 61.8513 GeneID:51181,Genbank:NM_001195218.1,HGNC:HGNC:18985,MIM:608347 dicarbonyl and L-xylulose reductase GO:0005634,GO:0005881,GO:0005886,GO:0005902,GO:0005903,GO:0005997,GO:0006006,GO:0006739,GO:0016655,GO:0019640,GO:0042732,GO:0042802,GO:0050038,GO:0051289,GO:0055114,GO:0070062 nucleus|cytoplasmic microtubule|plasma membrane|microvillus|brush border|xylulose metabolic process|glucose metabolic process|NADP metabolic process|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|glucuronate catabolic process to xylulose 5-phosphate|D-xylose metabolic process|identical protein binding|L-xylulose reductase (NADP+) activity|protein homotetramerization|oxidation-reduction process|extracellular exosome hsa00040 Pentose and glucuronate interconversions DDA1 2423.26870742932 2540.36972984977 2306.16768500887 0.907807890288965 -0.139541067251243 0.335330552329047 1 28.1002 29.0095 24.8029 28.0738 GeneID:79016,Genbank:NM_024050.5,HGNC:HGNC:28360 DET1 and DDB1 associated 1 GO:0005654,GO:0032434,GO:0043687,GO:0080008 nucleoplasm|regulation of proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex DDAH1 1476.81088827374 1441.78120584484 1511.84057070264 1.04859223061986 0.0684537615832313 0.814858515877476 1 11.2964 10.3838 14.3408 8.8432 GeneID:23576,Genbank:NM_001134445.1,HGNC:HGNC:2715,MIM:604743 dimethylarginine dimethylaminohydrolase 1 GO:0000052,GO:0003073,GO:0003824,GO:0005739,GO:0005829,GO:0006527,GO:0007263,GO:0008285,GO:0016403,GO:0016597,GO:0043116,GO:0045429,GO:0045766,GO:0046872,GO:0050999,GO:0070062,GO:1900038 citrulline metabolic process|regulation of systemic arterial blood pressure|catalytic activity|mitochondrion|cytosol|arginine catabolic process|nitric oxide mediated signal transduction|negative regulation of cell proliferation|dimethylargininase activity|amino acid binding|negative regulation of vascular permeability|positive regulation of nitric oxide biosynthetic process|positive regulation of angiogenesis|metal ion binding|regulation of nitric-oxide synthase activity|extracellular exosome|negative regulation of cellular response to hypoxia DDAH2 1424.34885839335 1171.01897094183 1677.67874584488 1.43266572743527 0.518702036238406 0.000395285461249347 0.0550512343249526 28.3593 27.7208 38.7567 41.9607 GeneID:23564,Genbank:NM_013974.2,HGNC:HGNC:2716,MIM:604744 dimethylarginine dimethylaminohydrolase 2 GO:0000052,GO:0003824,GO:0005739,GO:0005815,GO:0005829,GO:0006527,GO:0006809,GO:0007263,GO:0016403,GO:0016597,GO:0043066,GO:0045429,GO:0050999,GO:0070062 citrulline metabolic process|catalytic activity|mitochondrion|microtubule organizing center|cytosol|arginine catabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction|dimethylargininase activity|amino acid binding|negative regulation of apoptotic process|positive regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity|extracellular exosome DDB1 6677.5032224643 6642.13630524156 6712.87013968704 1.01064925969521 0.0152824046668072 0.923221163421027 1 50.741 54.7539 53.8476 54.5611 GeneID:1642,Genbank:NM_001923.4,HGNC:HGNC:2717,MIM:600045 damage specific DNA binding protein 1 hsa03420,hsa04120,hsa05161,hsa05170,hsa05203 Nucleotide excision repair|Ubiquitin mediated proteolysis|Hepatitis B|Human immunodeficiency virus 1 infection|Viral carcinogenesis DDB2 461.436100076072 425.653206886009 497.218993266136 1.16813167438274 0.224202907156197 0.216147109111921 1 7.04845 7.71208 9.03817 8.75444 GeneID:1643,Genbank:NM_000107.2,HGNC:HGNC:2718,MIM:600811 damage specific DNA binding protein 2 hsa03420,hsa04115,hsa04120,hsa05161,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 Nucleotide excision repair|p53 signaling pathway|Ubiquitin mediated proteolysis|Hepatitis B|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer DDHD1 190.080742112735 166.889766000833 213.271718224637 1.27791969115453 0.353797175241423 0.295376190830349 1 0.561905 0.426682 0.738318 0.494408 GeneID:80821,Genbank:NM_030637.2,HGNC:HGNC:19714,MIM:614603 DDHD domain containing 1 GO:0004620,GO:0005737,GO:0005829,GO:0006654,GO:0016042,GO:0046872,GO:0090141 phospholipase activity|cytoplasm|cytosol|phosphatidic acid biosynthetic process|lipid catabolic process|metal ion binding|positive regulation of mitochondrial fission DDHD2 732.328692581016 808.928933484513 655.728451677519 0.810613175687668 -0.302914469780456 0.0621826858977477 0.891600624295727 4.44811 4.47204 3.88798 3.326 GeneID:23259,Genbank:NM_015214.2,HGNC:HGNC:29106,MIM:615003 DDHD domain containing 2 GO:0004620,GO:0004806,GO:0005793,GO:0005794,GO:0005815,GO:0005829,GO:0006654,GO:0006888,GO:0007626,GO:0008542,GO:0016020,GO:0019433,GO:0030134,GO:0034389,GO:0046872,GO:0090141 phospholipase activity|triglyceride lipase activity|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|microtubule organizing center|cytosol|phosphatidic acid biosynthetic process|ER to Golgi vesicle-mediated transport|locomotory behavior|visual learning|membrane|triglyceride catabolic process|COPII-coated ER to Golgi transport vesicle|lipid particle organization|metal ion binding|positive regulation of mitochondrial fission DDI2 55.005651300125 51.3702363104063 58.6410662898437 1.14153779506684 0.190978626406968 0.661790368178549 1 0.919322 1.40045 1.55337 1.25057 GeneID:84301,Genbank:NM_032341.4,HGNC:HGNC:24578 DNA damage inducible 1 homolog 2 GO:0004190,GO:0005654,GO:0005829,GO:0016485,GO:0042802,GO:0043130 aspartic-type endopeptidase activity|nucleoplasm|cytosol|protein processing|identical protein binding|ubiquitin binding DDIAS 193.930521236264 219.192118840469 168.668923632059 0.769502683419099 -0.378001737341445 0.105392191726491 1 2.27694 2.06197 1.92276 1.4353 GeneID:220042,Genbank:NM_145018.3,HGNC:HGNC:26351 DNA damage induced apoptosis suppressor GO:0005634,GO:0005737,GO:0006915,GO:0007050,GO:0097752,GO:1902230 nucleus|cytoplasm|apoptotic process|cell cycle arrest|regulation of DNA stability|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage DDIT3 611.975342998942 579.464932513155 644.485753484728 1.1122083793571 0.153427111533611 0.445546034560074 1 12.5194 12.0357 12.4784 15.6458 GeneID:1649,Genbank:NM_001195057.1,HGNC:HGNC:2726,MIM:126337 DNA damage inducible transcript 3 hsa04010,hsa04141,hsa04210,hsa04932,hsa05202 MAPK signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease (NAFLD)|Transcriptional misregulation in cancer DDIT4 2676.19672981274 2589.66502769362 2762.72843193187 1.06682849032115 0.0933282585880883 0.823186351153606 1 72.1015 77.7909 61.9963 98.8454 GeneID:54541,Genbank:NM_019058.3,HGNC:HGNC:24944,MIM:607729 DNA damage inducible transcript 4 hsa04140,hsa04150,hsa04151,hsa05206 Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|MicroRNAs in cancer DDIT4L 9.43613814750856 6.75513842292525 12.1171378720919 1.79376603608438 0.842991729391666 0.382521030964241 1 0.162414 0.0967918 0.272781 0.199222 GeneID:115265,Genbank:NM_145244.3,HGNC:HGNC:30555,MIM:607730 DNA damage inducible transcript 4 like GO:0005737,GO:0009968 cytoplasm|negative regulation of signal transduction DDN 7.65374356152548 4.65077399104097 10.65671313201 2.29138486465663 1.19621979635504 0.344692163276917 1 0.0505866 0.0356767 0.047053 0.132204 GeneID:23109,Genbank:XM_011538055.3,HGNC:HGNC:24458,MIM:610588 dendrin GO:0000978,GO:0000982,GO:0005634,GO:0005737,GO:0005789,GO:0032591,GO:0042995,GO:0043204,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|cytoplasm|endoplasmic reticulum membrane|dendritic spine membrane|cell projection|perikaryon|positive regulation of transcription from RNA polymerase II promoter DDO 29.2239366178469 27.4243811993964 31.0234920362974 1.13123763160717 0.177902018567955 0.784595331635776 1 0.407748 0.73142 0.921509 0.427711 GeneID:8528,Genbank:NM_004032.2,HGNC:HGNC:2727,MIM:124450 D-aspartate oxidase GO:0005102,GO:0005777,GO:0005782,GO:0005829,GO:0006531,GO:0006533,GO:0007320,GO:0007625,GO:0008445,GO:0019478,GO:0034641,GO:0042445,GO:0048037,GO:0071949 receptor binding|peroxisome|peroxisomal matrix|cytosol|aspartate metabolic process|aspartate catabolic process|insemination|grooming behavior|D-aspartate oxidase activity|D-amino acid catabolic process|cellular nitrogen compound metabolic process|hormone metabolic process|cofactor binding|FAD binding hsa00250,hsa04146 Alanine, aspartate and glutamate metabolism|Peroxisome DDOST 10568.6955682138 10426.7563503329 10710.6347860947 1.02722595850748 0.0387535656499718 0.781859714484964 1 201.941 214.041 206.446 226.308 GeneID:1650,Genbank:NM_005216.4,HGNC:HGNC:2728,MIM:602202 dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit GO:0005783,GO:0005789,GO:0005886,GO:0006486,GO:0006487,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0034097,GO:0035577,GO:0042110,GO:0043231,GO:0043234,GO:0043312 endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|protein glycosylation|protein N-linked glycosylation|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|response to cytokine|azurophil granule membrane|T cell activation|intracellular membrane-bounded organelle|protein complex|neutrophil degranulation hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum DDR1 5719.04964287746 5187.13298019897 6250.96630555595 1.20509081402347 0.269141870110461 0.0450342511668665 0.789998430107923 36.1932 38.8987 45.6403 48.1267 GeneID:780,Genbank:XM_011514887.2,HGNC:HGNC:2730,MIM:600408 discoidin domain receptor tyrosine kinase 1 DDR2 703.442129857624 662.399618300971 744.484641414277 1.12392069808834 0.168540245068783 0.481492141947333 1 2.23485 1.86016 2.80585 1.9789 GeneID:4921,Genbank:NM_001354983.1,HGNC:HGNC:2731,MIM:191311 discoidin domain receptor tyrosine kinase 2 GO:0001503,GO:0003416,GO:0004714,GO:0005518,GO:0005524,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0007165,GO:0010715,GO:0010763,GO:0015629,GO:0016324,GO:0018108,GO:0030198,GO:0030199,GO:0030500,GO:0031214,GO:0035988,GO:0038062,GO:0038063,GO:0045669,GO:0045860,GO:0046777,GO:0048146,GO:0051091,GO:0070062,GO:0090091 ossification|endochondral bone growth|transmembrane receptor protein tyrosine kinase activity|collagen binding|ATP binding|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|signal transduction|regulation of extracellular matrix disassembly|positive regulation of fibroblast migration|actin cytoskeleton|apical plasma membrane|peptidyl-tyrosine phosphorylation|extracellular matrix organization|collagen fibril organization|regulation of bone mineralization|biomineral tissue development|chondrocyte proliferation|protein tyrosine kinase collagen receptor activity|collagen-activated tyrosine kinase receptor signaling pathway|positive regulation of osteoblast differentiation|positive regulation of protein kinase activity|protein autophosphorylation|positive regulation of fibroblast proliferation|positive regulation of DNA binding transcription factor activity|extracellular exosome|positive regulation of extracellular matrix disassembly DDRGK1 1446.61622569245 1420.48965549918 1472.74279588572 1.03678530159249 0.0521171705285208 0.732045302128322 1 33.7257 33.5638 35.3974 35.8572 GeneID:65992,Genbank:NM_023935.2,HGNC:HGNC:16110,MIM:616177 DDRGK domain containing 1 GO:0001103,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0008284,GO:0010628,GO:0010629,GO:0030335,GO:0032436,GO:0033146,GO:0034976,GO:0043066,GO:0044389,GO:0045944,GO:0051092,GO:1901800,GO:1902808,GO:1903721,GO:1905050,GO:1905552,GO:1905636,GO:1990592 RNA polymerase II repressing transcription factor binding|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|positive regulation of cell proliferation|positive regulation of gene expression|negative regulation of gene expression|positive regulation of cell migration|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|negative regulation of apoptotic process|ubiquitin-like protein ligase binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal protein catabolic process|positive regulation of cell cycle G1/S phase transition|positive regulation of I-kappaB phosphorylation|positive regulation of metallopeptidase activity|positive regulation of protein localization to endoplasmic reticulum|positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding|protein K69-linked ufmylation DDT 427.407018958471 431.764386427814 423.049651489129 0.979815994063832 -0.0294172531867413 0.868142672999459 1 36.2896 35.6205 32.7813 37.8484 GeneID:1652,Genbank:NM_001355.3,HGNC:HGNC:2732,MIM:602750 D-dopachrome tautomerase GO:0004167,GO:0005126,GO:0005615,GO:0005737,GO:0010760,GO:0032760,GO:0033981,GO:0042438,GO:0050178,GO:0050729,GO:0070062,GO:0070374 dopachrome isomerase activity|cytokine receptor binding|extracellular space|cytoplasm|negative regulation of macrophage chemotaxis|positive regulation of tumor necrosis factor production|D-dopachrome decarboxylase activity|melanin biosynthetic process|phenylpyruvate tautomerase activity|positive regulation of inflammatory response|extracellular exosome|positive regulation of ERK1 and ERK2 cascade DDTL 31.9417012936643 33.8335270444191 30.0498755429094 0.888168576201286 -0.171094565870725 0.757473524195334 1 0.0879791 0.062519 0.175662 0.0948258 GeneID:100037417,Genbank:XM_011529816.3,HGNC:HGNC:33446 D-dopachrome tautomerase like GO:0005737,GO:0016829,GO:0070062 cytoplasm|lyase activity|extracellular exosome DDX1 1512.36450343461 1592.12421403871 1432.60479283052 0.899807175971814 -0.152312222416205 0.306012274210446 1 20.1297 18.7316 18.8303 16.5341 GeneID:1653,Genbank:NM_004939.2,HGNC:HGNC:2734,MIM:601257 DEAD-box helicase 1 DDX10 388.482046762535 415.898788120692 361.065305404379 0.868156666279103 -0.203972682092099 0.290269281185646 1 3.75338 3.21972 3.22289 2.71163 GeneID:1662,Genbank:NM_004398.3,HGNC:HGNC:2735,MIM:601235 DEAD-box helicase 10 DDX11 895.087738943287 868.409869564985 921.76560832159 1.06144073279975 0.0860238183624723 0.586123120392028 1 3.63766 3.52753 3.918 3.61913 GeneID:1663,Genbank:NM_030653.3,HGNC:HGNC:2736,MIM:601150 DEAD/H-box helicase 11 GO:0003677,GO:0003723,GO:0004003,GO:0005524,GO:0005634,GO:0006139,GO:0007049 DNA binding|RNA binding|ATP-dependent DNA helicase activity|ATP binding|nucleus|nucleobase-containing compound metabolic process|cell cycle DDX17 5798.25960046701 5887.4334652332 5709.08573570082 0.969707049670187 -0.0443791226612947 0.745572111442839 1 48.873 48.0717 50.5481 45.5302 GeneID:10521,Genbank:NM_006386.4,HGNC:HGNC:2740,MIM:608469 DEAD-box helicase 17 GO:0000380,GO:0000381,GO:0001837,GO:0003713,GO:0003723,GO:0003724,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006351,GO:0006357,GO:0006364,GO:0006396,GO:0008186,GO:0010501,GO:0010586,GO:0016020,GO:0016607,GO:0030520,GO:0030521,GO:0031047,GO:0045445,GO:0045944,GO:0051607,GO:2001014 alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|epithelial to mesenchymal transition|transcription coactivator activity|RNA binding|RNA helicase activity|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|rRNA processing|RNA processing|RNA-dependent ATPase activity|RNA secondary structure unwinding|miRNA metabolic process|membrane|nuclear speck|intracellular estrogen receptor signaling pathway|androgen receptor signaling pathway|gene silencing by RNA|myoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|defense response to virus|regulation of skeletal muscle cell differentiation DDX18 999.157099511682 1116.72487252733 881.589326496034 0.789441829571552 -0.341095130613752 0.0762644222289915 0.94157495521624 12.2506 10.3996 9.78869 8.26391 GeneID:8886,Genbank:NM_006773.3,HGNC:HGNC:2741,MIM:606355 DEAD-box helicase 18 GO:0003723,GO:0004004,GO:0005524,GO:0005694,GO:0005730,GO:0005737,GO:0010501,GO:0016020,GO:0071392 RNA binding|ATP-dependent RNA helicase activity|ATP binding|chromosome|nucleolus|cytoplasm|RNA secondary structure unwinding|membrane|cellular response to estradiol stimulus DDX19A 2290.11693005707 2285.52686018025 2294.70699993388 1.0040166405014 0.005783180613282 0.978897811119328 1 18.8742 19.8076 20.5485 19.4479 GeneID:55308,Genbank:NM_001320525.1,HGNC:HGNC:25628 DEAD-box helicase 19A GO:0003723,GO:0004004,GO:0005524,GO:0005643,GO:0005730,GO:0005737,GO:0008380,GO:0010468,GO:0010501,GO:0015031,GO:0016020,GO:0031965,GO:0051028,GO:0071013 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nuclear pore|nucleolus|cytoplasm|RNA splicing|regulation of gene expression|RNA secondary structure unwinding|protein transport|membrane|nuclear membrane|mRNA transport|catalytic step 2 spliceosome DDX19B 815.301873019122 795.09329837183 835.510447666413 1.05083321589724 0.0715337086036495 0.6707736182262 1 6.63459 7.23023 7.56777 7.17218 GeneID:11269,Genbank:NM_001257174.1,HGNC:HGNC:2742,MIM:605812 DEAD-box helicase 19B GO:0003723,GO:0004004,GO:0004386,GO:0005524,GO:0005635,GO:0005643,GO:0005730,GO:0005737,GO:0006406,GO:0008380,GO:0010468,GO:0010501,GO:0016020,GO:0031965,GO:0070062,GO:0071013 RNA binding|ATP-dependent RNA helicase activity|helicase activity|ATP binding|nuclear envelope|nuclear pore|nucleolus|cytoplasm|mRNA export from nucleus|RNA splicing|regulation of gene expression|RNA secondary structure unwinding|membrane|nuclear membrane|extracellular exosome|catalytic step 2 spliceosome DDX20 539.796520841427 570.721099517932 508.871942164922 0.891629804110534 -0.165483253162043 0.330102570173266 1 6.23224 6.82363 6.09812 5.61802 GeneID:11218,Genbank:NM_007204.4,HGNC:HGNC:2743,MIM:606168 DEAD-box helicase 20 GO:0000122,GO:0000244,GO:0000387,GO:0003677,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005856,GO:0006396,GO:0008285,GO:0010501,GO:0016020,GO:0019904,GO:0030674,GO:0032797,GO:0034719,GO:0042826,GO:0043065,GO:0048477,GO:0050810,GO:0051170,GO:0070491,GO:0090571,GO:0097504 negative regulation of transcription from RNA polymerase II promoter|spliceosomal tri-snRNP complex assembly|spliceosomal snRNP assembly|DNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|cytoskeleton|RNA processing|negative regulation of cell proliferation|RNA secondary structure unwinding|membrane|protein domain specific binding|protein binding, bridging|SMN complex|SMN-Sm protein complex|histone deacetylase binding|positive regulation of apoptotic process|oogenesis|regulation of steroid biosynthetic process|nuclear import|repressing transcription factor binding|RNA polymerase II transcription repressor complex|Gemini of coiled bodies hsa03013 RNA transport DDX21 3229.05758264221 3789.49097179216 2668.62419349227 0.704217060643952 -0.505907915956304 0.0179597626498618 0.546850871863472 30.1482 25.9731 22.5321 17.2938 GeneID:9188,Genbank:NM_004728.3,HGNC:HGNC:2744,MIM:606357 DExD-box helicase 21 GO:0001649,GO:0003723,GO:0003725,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0006366,GO:0009615,GO:0010501,GO:0016020,GO:0019843,GO:0030515,GO:0035198,GO:0043330,GO:0045815,GO:0097322 osteoblast differentiation|RNA binding|double-stranded RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|transcription from RNA polymerase II promoter|response to virus|RNA secondary structure unwinding|membrane|rRNA binding|snoRNA binding|miRNA binding|response to exogenous dsRNA|positive regulation of gene expression, epigenetic|7SK snRNA binding DDX23 2731.14581016797 2552.14902680525 2910.14259353069 1.1402714194843 0.189377270825822 0.169276852109799 1 20.8493 21.3831 24.4663 23.7772 GeneID:9416,Genbank:NM_004818.2,HGNC:HGNC:17347,MIM:612172 DEAD-box helicase 23 GO:0000354,GO:0000375,GO:0000398,GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005682,GO:0005730,GO:0005737,GO:0008380,GO:0010501,GO:0070062,GO:0071013 cis assembly of pre-catalytic spliceosome|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|U5 snRNP|nucleolus|cytoplasm|RNA splicing|RNA secondary structure unwinding|extracellular exosome|catalytic step 2 spliceosome hsa03040 Spliceosome DDX24 3948.94674586626 3693.79212259411 4204.1013691384 1.13815321209411 0.1866947786025 0.164847190955602 1 38.6803 39.7967 44.998 44.2702 GeneID:57062,Genbank:NM_020414.3,HGNC:HGNC:13266,MIM:606181 DEAD-box helicase 24 GO:0003723,GO:0003724,GO:0004004,GO:0005524,GO:0005730,GO:0005737,GO:0010501,GO:0016020,GO:0016070 RNA binding|RNA helicase activity|ATP-dependent RNA helicase activity|ATP binding|nucleolus|cytoplasm|RNA secondary structure unwinding|membrane|RNA metabolic process DDX27 1761.76311382916 1848.15015726684 1675.37607039147 0.906515124760813 -0.14159700405705 0.31847321595682 1 17.3776 17.832 16.5503 15.374 GeneID:55661,Genbank:NM_001348187.1,HGNC:HGNC:15837,MIM:616621 DEAD-box helicase 27 GO:0003723,GO:0004004,GO:0005524,GO:0005694,GO:0005730,GO:0005737,GO:0006364,GO:0010501 RNA binding|ATP-dependent RNA helicase activity|ATP binding|chromosome|nucleolus|cytoplasm|rRNA processing|RNA secondary structure unwinding DDX28 431.739535331273 426.374618007138 437.104452655409 1.02516527531217 0.0358565171957287 0.923231552280248 1 6.46022 8.45706 7.35448 8.22694 GeneID:55794,Genbank:NM_018380.3,HGNC:HGNC:17330,MIM:607618 DEAD-box helicase 28 GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005730,GO:0005739,GO:0005829,GO:0010501,GO:0019843,GO:0035770,GO:0042645,GO:1902775 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleolus|mitochondrion|cytosol|RNA secondary structure unwinding|rRNA binding|ribonucleoprotein granule|mitochondrial nucleoid|mitochondrial large ribosomal subunit assembly DDX31 410.496646588801 447.331001430864 373.662291746738 0.835314991698576 -0.259607764045445 0.154052383180309 1 1.74312 1.85976 1.61444 1.46215 GeneID:64794,Genbank:NM_001322340.1,HGNC:HGNC:16715,MIM:616533 DEAD-box helicase 31 GO:0003723,GO:0004004,GO:0005524,GO:0005730,GO:0005737,GO:0005794,GO:0010501,GO:0042254,GO:0043231 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleolus|cytoplasm|Golgi apparatus|RNA secondary structure unwinding|ribosome biogenesis|intracellular membrane-bounded organelle DDX39A 3791.85094304829 3779.01753726086 3804.68434883572 1.00679192708734 0.00976555347708978 0.959455670993972 1 49.8075 51.4295 51.7266 52.9853 GeneID:10212,Genbank:NM_005804.3,HGNC:HGNC:17821 DExD-box helicase 39A GO:0000398,GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005737,GO:0006369,GO:0006405,GO:0006406,GO:0006974,GO:0010468,GO:0010501,GO:0016020,GO:0016607,GO:0016887,GO:0031124,GO:0042802 mRNA splicing, via spliceosome|RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|spliceosomal complex|nucleolus|cytoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|cellular response to DNA damage stimulus|regulation of gene expression|RNA secondary structure unwinding|membrane|nuclear speck|ATPase activity|mRNA 3'-end processing|identical protein binding DDX39B 5508.4329961255 5470.96242981971 5545.9035624313 1.01369797975638 0.0196278811275025 0.893700366224383 1 87.658 90.4276 91.2895 92.729 GeneID:7919,Genbank:NM_080598.5,HGNC:HGNC:13917,MIM:142560 DExD-box helicase 39B GO:0000245,GO:0000346,GO:0000398,GO:0001889,GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005737,GO:0006369,GO:0006405,GO:0006406,GO:0008186,GO:0008380,GO:0010501,GO:0016363,GO:0016607,GO:0016887,GO:0017070,GO:0030621,GO:0031124,GO:0032403,GO:0032786,GO:0042802,GO:0043008,GO:0045727,GO:0046784,GO:0061051,GO:1904707,GO:2000002,GO:2000573 spliceosomal complex assembly|transcription export complex|mRNA splicing, via spliceosome|liver development|RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|spliceosomal complex|nucleolus|cytoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|RNA-dependent ATPase activity|RNA splicing|RNA secondary structure unwinding|nuclear matrix|nuclear speck|ATPase activity|U6 snRNA binding|U4 snRNA binding|mRNA 3'-end processing|protein complex binding|positive regulation of DNA-templated transcription, elongation|identical protein binding|ATP-dependent protein binding|positive regulation of translation|viral mRNA export from host cell nucleus|positive regulation of cell growth involved in cardiac muscle cell development|positive regulation of vascular smooth muscle cell proliferation|negative regulation of DNA damage checkpoint|positive regulation of DNA biosynthetic process hsa03013,hsa03015,hsa03040,hsa05164 RNA transport|mRNA surveillance pathway|Spliceosome|Influenza A DDX3X 4966.71560737873 5510.32740875371 4423.10380600374 0.802693465904983 -0.31707894107853 0.112610177454004 1 35.9974 30.9843 30.3616 23.8458 GeneID:1654,Genbank:NM_001356.4,HGNC:HGNC:2745,MIM:300160 DEAD-box helicase 3, X-linked GO:0003677,GO:0003723,GO:0003924,GO:0004003,GO:0004004,GO:0005524,GO:0005576,GO:0005634,GO:0005730,GO:0005737,GO:0005741,GO:0005829,GO:0006351,GO:0007059,GO:0008134,GO:0008143,GO:0008190,GO:0008625,GO:0009615,GO:0010494,GO:0010501,GO:0010628,GO:0016032,GO:0016055,GO:0016607,GO:0016887,GO:0017111,GO:0017148,GO:0030307,GO:0030308,GO:0031333,GO:0031369,GO:0032728,GO:0033592,GO:0034063,GO:0034774,GO:0035556,GO:0035613,GO:0042256,GO:0043024,GO:0043065,GO:0043066,GO:0043154,GO:0043273,GO:0043280,GO:0043312,GO:0043539,GO:0045070,GO:0045087,GO:0045296,GO:0045727,GO:0045944,GO:0045948,GO:0048027,GO:0070062,GO:0071243,GO:0071470,GO:0071651,GO:0071902,GO:0090263,GO:0097193,GO:1900087,GO:1903608,GO:1904813,GO:2001243 DNA binding|RNA binding|GTPase activity|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|ATP binding|extracellular region|nucleus|nucleolus|cytoplasm|mitochondrial outer membrane|cytosol|transcription, DNA-templated|chromosome segregation|transcription factor binding|poly(A) binding|eukaryotic initiation factor 4E binding|extrinsic apoptotic signaling pathway via death domain receptors|response to virus|cytoplasmic stress granule|RNA secondary structure unwinding|positive regulation of gene expression|viral process|Wnt signaling pathway|nuclear speck|ATPase activity|nucleoside-triphosphatase activity|negative regulation of translation|positive regulation of cell growth|negative regulation of cell growth|negative regulation of protein complex assembly|translation initiation factor binding|positive regulation of interferon-beta production|RNA strand annealing activity|stress granule assembly|secretory granule lumen|intracellular signal transduction|RNA stem-loop binding|mature ribosome assembly|ribosomal small subunit binding|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|CTPase activity|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|neutrophil degranulation|protein serine/threonine kinase activator activity|positive regulation of viral genome replication|innate immune response|cadherin binding|positive regulation of translation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of translational initiation|mRNA 5'-UTR binding|extracellular exosome|cellular response to arsenic-containing substance|cellular response to osmotic stress|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of protein serine/threonine kinase activity|positive regulation of canonical Wnt signaling pathway|intrinsic apoptotic signaling pathway|positive regulation of G1/S transition of mitotic cell cycle|protein localization to cytoplasmic stress granule|ficolin-1-rich granule lumen|negative regulation of intrinsic apoptotic signaling pathway hsa04622,hsa05161,hsa05203 RIG-I-like receptor signaling pathway|Hepatitis B|Viral carcinogenesis DDX41 2614.98013841867 2656.17843418916 2573.78184264818 0.968979270940381 -0.045462292024502 0.72542913537474 1 23.1394 24.5339 23.4291 23.3352 GeneID:51428,Genbank:NM_016222.3,HGNC:HGNC:18674,MIM:608170 DEAD-box helicase 41 GO:0000398,GO:0003677,GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0005783,GO:0005829,GO:0006915,GO:0008283,GO:0010501,GO:0016020,GO:0030154,GO:0032479,GO:0032481,GO:0035458,GO:0045944,GO:0046872,GO:0051607,GO:0071013 mRNA splicing, via spliceosome|DNA binding|RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleolus|cytoplasm|endoplasmic reticulum|cytosol|apoptotic process|cell proliferation|RNA secondary structure unwinding|membrane|cell differentiation|regulation of type I interferon production|positive regulation of type I interferon production|cellular response to interferon-beta|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|defense response to virus|catalytic step 2 spliceosome DDX42 2893.240319403 2912.95790415287 2873.52273465313 0.986462156063592 -0.0196643894090151 0.896555523706091 1 18.2243 17.815 19.6986 16.8297 GeneID:11325,Genbank:XM_017024111.1,HGNC:HGNC:18676,MIM:613369 DEAD-box helicase 42 GO:0000398,GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0008104,GO:0010501,GO:0015030,GO:0016020,GO:0016607,GO:0042981 mRNA splicing, via spliceosome|RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|protein localization|RNA secondary structure unwinding|Cajal body|membrane|nuclear speck|regulation of apoptotic process hsa03040 Spliceosome DDX46 911.367874684401 951.756157513895 870.979591854907 0.91512892769721 -0.127953083461976 0.667442039317994 1 5.44905 4.37334 5.19978 3.97281 GeneID:9879,Genbank:NM_001300860.1,HGNC:HGNC:18681,MIM:617848 DEAD-box helicase 46 GO:0003723,GO:0004386,GO:0005524,GO:0006397,GO:0008380,GO:0015030,GO:0016020,GO:0016607 RNA binding|helicase activity|ATP binding|mRNA processing|RNA splicing|Cajal body|membrane|nuclear speck hsa03040 Spliceosome DDX47 1088.87374849926 1165.85749123776 1011.89000576077 0.86793627297147 -0.204338976230492 0.180856441418607 1 25.7359 24.658 22.3205 21.9121 GeneID:51202,Genbank:NM_016355.3,HGNC:HGNC:18682,MIM:615428 DEAD-box helicase 47 GO:0003723,GO:0004004,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0006397,GO:0008380,GO:0008625,GO:0010501,GO:0016020 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleoplasm|nucleolus|cytoplasm|rRNA processing|mRNA processing|RNA splicing|extrinsic apoptotic signaling pathway via death domain receptors|RNA secondary structure unwinding|membrane DDX49 1764.12215671221 1708.5319019871 1819.71241143731 1.06507370996169 0.0909532776965354 0.54029743993039 1 27.2308 28.8708 30.0675 31.3831 GeneID:54555,Genbank:NM_019070.4,HGNC:HGNC:18684 DEAD-box helicase 49 GO:0003723,GO:0004004,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0010501 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleoplasm|nucleolus|cytoplasm|rRNA processing|RNA secondary structure unwinding DDX5 14431.2503694842 14688.6889462102 14173.8117927582 0.964947371726815 -0.051477835013603 0.714618913591857 1 113.219 104.546 108.09 105.201 GeneID:1655,Genbank:NM_001320595.1,HGNC:HGNC:2746,MIM:180630 DEAD-box helicase 5 hsa03040,hsa05202,hsa05205 Spliceosome|Transcriptional misregulation in cancer|Proteoglycans in cancer DDX50 731.967308254213 750.04494701133 713.889669497096 0.951795852157527 -0.0712759275131483 0.666117211540705 1 2.93723 2.99674 3.10434 2.662 GeneID:79009,Genbank:XM_024448162.1,HGNC:HGNC:17906,MIM:610373 DExD-box helicase 50 GO:0003723,GO:0004004,GO:0005524,GO:0005730,GO:0005737,GO:0005886,GO:0010501,GO:0016020 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleolus|cytoplasm|plasma membrane|RNA secondary structure unwinding|membrane DDX51 754.568357485151 751.67006569722 757.466649273082 1.00771160624906 0.0110828176427215 0.972629286267917 1 4.96812 5.65035 5.52564 5.37137 GeneID:317781,Genbank:NM_175066.3,HGNC:HGNC:20082 DEAD-box helicase 51 GO:0003723,GO:0004004,GO:0005524,GO:0005730,GO:0005737,GO:0006364,GO:0010501,GO:0016020 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleolus|cytoplasm|rRNA processing|RNA secondary structure unwinding|membrane DDX52 1035.96698592615 1062.83866962395 1009.09530222835 0.949434124922635 -0.0748601902939265 0.637802433141873 1 4.6233 4.64998 5.0898 3.98464 GeneID:11056,Genbank:NM_007010.4,HGNC:HGNC:20038,MIM:612500 DExD-box helicase 52 GO:0003723,GO:0004004,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0010501,GO:0016020 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleoplasm|nucleolus|cytoplasm|rRNA processing|RNA secondary structure unwinding|membrane DDX54 2405.48512996401 2370.42386557761 2440.54639435042 1.02958227420467 0.0420591207369552 0.779987343248485 1 18.1795 19.1193 19.6338 19.3033 GeneID:79039,Genbank:NM_024072.3,HGNC:HGNC:20084,MIM:611665 DEAD-box helicase 54 GO:0003714,GO:0003723,GO:0004004,GO:0005102,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0005794,GO:0006351,GO:0006355,GO:0006396,GO:0010501,GO:0016020,GO:0016070,GO:0030331,GO:0030520 transcription corepressor activity|RNA binding|ATP-dependent RNA helicase activity|receptor binding|ATP binding|nucleus|nucleolus|cytoplasm|Golgi apparatus|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA processing|RNA secondary structure unwinding|membrane|RNA metabolic process|estrogen receptor binding|intracellular estrogen receptor signaling pathway DDX55 616.008594649318 671.808044488386 560.20914481025 0.833882757740533 -0.26208353701655 0.116822007047414 1 4.87937 5.0778 4.0599 4.33306 GeneID:57696,Genbank:NM_020936.2,HGNC:HGNC:20085 DEAD-box helicase 55 GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0010501,GO:0016020 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleolus|cytoplasm|cytosol|RNA secondary structure unwinding|membrane DDX56 3030.85169163612 3167.69592961877 2894.00745365347 0.913600142802141 -0.130365218683187 0.337752070759822 1 43.1517 42.0549 38.4634 41.6321 GeneID:54606,Genbank:NM_001257189.1,HGNC:HGNC:18193,MIM:608023 DEAD-box helicase 56 GO:0003723,GO:0004004,GO:0005524,GO:0005730,GO:0005737,GO:0006364,GO:0010501,GO:0010976,GO:0016020 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleolus|cytoplasm|rRNA processing|RNA secondary structure unwinding|positive regulation of neuron projection development|membrane DDX58 578.915974385774 293.152648914744 864.679299856803 2.94958719649255 1.56051305913699 0.378363963774674 1 2.2137 1.74076 10.992 1.45876 GeneID:23586,Genbank:NM_014314.3,HGNC:HGNC:19102,MIM:609631 DExD/H-box helicase 58 GO:0002230,GO:0003690,GO:0003725,GO:0003727,GO:0004386,GO:0005524,GO:0005737,GO:0005829,GO:0005923,GO:0008270,GO:0009597,GO:0009615,GO:0010628,GO:0015629,GO:0016032,GO:0016579,GO:0030334,GO:0031625,GO:0032480,GO:0032587,GO:0032725,GO:0032727,GO:0032728,GO:0032755,GO:0032757,GO:0034344,GO:0035549,GO:0039528,GO:0039529,GO:0042802,GO:0042993,GO:0045087,GO:0045944,GO:0051091,GO:0051607,GO:0060760,GO:0071360,GO:1902741,GO:1904469,GO:2000778 positive regulation of defense response to virus by host|double-stranded DNA binding|double-stranded RNA binding|single-stranded RNA binding|helicase activity|ATP binding|cytoplasm|cytosol|bicellular tight junction|zinc ion binding|detection of virus|response to virus|positive regulation of gene expression|actin cytoskeleton|viral process|protein deubiquitination|regulation of cell migration|ubiquitin protein ligase binding|negative regulation of type I interferon production|ruffle membrane|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|regulation of type III interferon production|positive regulation of interferon-beta secretion|cytoplasmic pattern recognition receptor signaling pathway in response to virus|RIG-I signaling pathway|identical protein binding|positive regulation of transcription factor import into nucleus|innate immune response|positive regulation of transcription from RNA polymerase II promoter|positive regulation of DNA binding transcription factor activity|defense response to virus|positive regulation of response to cytokine stimulus|cellular response to exogenous dsRNA|positive regulation of interferon-alpha secretion|positive regulation of tumor necrosis factor secretion|positive regulation of interleukin-6 secretion hsa04064,hsa04622,hsa04623,hsa05160,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169 NF-kappa B signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Herpes simplex infection|Epstein-Barr virus infection DDX59 321.539852753733 311.554848125915 331.524857381552 1.06409789279725 0.0896308791818185 0.659357727570186 1 2.69216 3.11574 3.53439 2.48947 GeneID:83479,Genbank:NM_001349802.2,HGNC:HGNC:25360,MIM:615464 DEAD-box helicase 59 GO:0003723,GO:0004004,GO:0005524,GO:0005622,GO:0005730,GO:0005737,GO:0010501,GO:0046872 RNA binding|ATP-dependent RNA helicase activity|ATP binding|intracellular|nucleolus|cytoplasm|RNA secondary structure unwinding|metal ion binding DDX6 2043.85971099834 2078.24525746165 2009.47416453503 0.966909058168327 -0.0485478902931957 0.827814199317966 1 13.9338 12.2969 14.7212 10.9818 GeneID:1656,Genbank:XM_011542645.1,HGNC:HGNC:2747,MIM:600326 DEAD-box helicase 6 GO:0000792,GO:0000932,GO:0001520,GO:0003723,GO:0003724,GO:0004004,GO:0004386,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006417,GO:0007283,GO:0010494,GO:0010501,GO:0016020,GO:0016442,GO:0019074,GO:0019827,GO:0019904,GO:0033962,GO:0036464,GO:0043186,GO:0043928,GO:0045296,GO:0045665,GO:0097227 heterochromatin|P-body|outer dense fiber|RNA binding|RNA helicase activity|ATP-dependent RNA helicase activity|helicase activity|ATP binding|nucleus|nucleolus|cytoplasm|mitochondrion|cytosol|regulation of translation|spermatogenesis|cytoplasmic stress granule|RNA secondary structure unwinding|membrane|RISC complex|viral RNA genome packaging|stem cell population maintenance|protein domain specific binding|cytoplasmic mRNA processing body assembly|cytoplasmic ribonucleoprotein granule|P granule|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|cadherin binding|negative regulation of neuron differentiation|sperm annulus hsa03018 RNA degradation DDX60 75.1106551271585 48.8620443708266 101.35926588349 2.07439674677238 1.05269184876092 0.525777288786236 1 0.158144 0.150135 0.61304 0.0599749 GeneID:55601,Genbank:NM_017631.5,HGNC:HGNC:25942,MIM:613974 DExD/H-box helicase 60 GO:0003690,GO:0003725,GO:0003727,GO:0004386,GO:0005524,GO:0005737,GO:0005829,GO:0009615,GO:0045087,GO:0045111,GO:0051607,GO:1900245,GO:1900246 double-stranded DNA binding|double-stranded RNA binding|single-stranded RNA binding|helicase activity|ATP binding|cytoplasm|cytosol|response to virus|innate immune response|intermediate filament cytoskeleton|defense response to virus|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway DDX60L 124.038849622422 80.7735034269933 167.30419581785 2.07127571195507 1.05051960657398 0.476095317183408 1 0.33994 0.245165 1.06169 0.146377 GeneID:91351,Genbank:XM_011532405.1,HGNC:HGNC:26429,MIM:616725 DExD/H-box 60 like GO:0003723,GO:0004386,GO:0005524 RNA binding|helicase activity|ATP binding DEAF1 889.70054059314 983.209005135138 796.192076051143 0.809789243073207 -0.304381615948089 0.0508201864396925 0.826491656848345 9.68271 8.7551 7.23788 7.72333 GeneID:10522,Genbank:NM_001293634.1,HGNC:HGNC:14677,MIM:602635 DEAF1, transcription factor GO:0000122,GO:0000977,GO:0001227,GO:0001650,GO:0001662,GO:0001843,GO:0003700,GO:0005576,GO:0005634,GO:0005667,GO:0005737,GO:0006357,GO:0006366,GO:0007281,GO:0008542,GO:0009653,GO:0033599,GO:0045892,GO:0045893,GO:0046872,GO:0048706 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|fibrillar center|behavioral fear response|neural tube closure|DNA binding transcription factor activity|extracellular region|nucleus|transcription factor complex|cytoplasm|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|germ cell development|visual learning|anatomical structure morphogenesis|regulation of mammary gland epithelial cell proliferation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|embryonic skeletal system development DEC1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0192667 0 0 GeneID:50514,Genbank:NM_017418.2,HGNC:HGNC:23658,MIM:604767 deleted in esophageal cancer 1 GO:0008285 negative regulation of cell proliferation DECR1 980.410935880879 917.934473126293 1042.88739863546 1.13612401447743 0.184120321908105 0.226516306011109 1 7.49898 7.70076 8.82887 8.79482 GeneID:1666,Genbank:NM_001330575.1,HGNC:HGNC:2753,MIM:222745 2,4-dienoyl-CoA reductase 1 GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006635,GO:0008670,GO:0016651,GO:0051289,GO:0070062,GO:0070402 nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|fatty acid beta-oxidation|2,4-dienoyl-CoA reductase (NADPH) activity|oxidoreductase activity, acting on NAD(P)H|protein homotetramerization|extracellular exosome|NADPH binding DECR2 229.786352134475 223.564543838508 236.008160430442 1.055660062988 0.0781453418982474 0.729560885950943 1 6.69496 7.10111 7.29254 8.11271 GeneID:26063,Genbank:NM_020664.3,HGNC:HGNC:2754,MIM:615839 2,4-dienoyl-CoA reductase 2 GO:0005102,GO:0005778,GO:0006636,GO:0008670,GO:0019166,GO:0033540 receptor binding|peroxisomal membrane|unsaturated fatty acid biosynthetic process|2,4-dienoyl-CoA reductase (NADPH) activity|trans-2-enoyl-CoA reductase (NADPH) activity|fatty acid beta-oxidation using acyl-CoA oxidase hsa04146 Peroxisome DEDD 1258.22168203145 1282.05142277548 1234.39194128742 0.962825608519749 -0.0546535808344865 0.708411517534102 1 10.3967 10.6921 10.9754 9.69376 GeneID:9191,Genbank:XM_005245600.3,HGNC:HGNC:2755,MIM:606841 death effector domain containing GO:0003677,GO:0005730,GO:0005737,GO:0006351,GO:0006355,GO:0007283,GO:0008625,GO:0042981 DNA binding|nucleolus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|spermatogenesis|extrinsic apoptotic signaling pathway via death domain receptors|regulation of apoptotic process DEDD2 603.982032182665 636.12111004147 571.842954323861 0.898952959266801 -0.153682471036537 0.341549397131267 1 10.9343 12.2807 10.5517 10.8254 GeneID:162989,Genbank:NM_001270614.1,HGNC:HGNC:24450,MIM:617078 death effector domain containing 2 GO:0003677,GO:0005730,GO:0006351,GO:0006396,GO:0008625,GO:0016075,GO:0019725,GO:0030159,GO:0030262,GO:0035556,GO:0045892,GO:2001238 DNA binding|nucleolus|transcription, DNA-templated|RNA processing|extrinsic apoptotic signaling pathway via death domain receptors|rRNA catabolic process|cellular homeostasis|receptor signaling complex scaffold activity|apoptotic nuclear changes|intracellular signal transduction|negative regulation of transcription, DNA-templated|positive regulation of extrinsic apoptotic signaling pathway DEF6 11.3084096128663 12.9241528945232 9.69266633120943 0.749965309936623 -0.415104230398663 0.673532338636018 1 0.2559 0.130233 0.138066 0.14691 GeneID:50619,Genbank:NM_022047.3,HGNC:HGNC:2760,MIM:610094 DEF6, guanine nucleotide exchange factor GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0016020,GO:0030175,GO:0048471 nucleoplasm|cytosol|cytoskeleton|plasma membrane|membrane|filopodium|perinuclear region of cytoplasm DEF8 1363.21987062748 1306.57461018357 1419.8651310714 1.0867080379527 0.119964388593828 0.426992934618027 1 8.58754 9.13634 9.40443 10.5842 GeneID:54849,Genbank:NM_207514.2,HGNC:HGNC:25969 differentially expressed in FDCP 8 homolog GO:0005622,GO:0032418,GO:0035556,GO:0045780,GO:0046872,GO:1900029 intracellular|lysosome localization|intracellular signal transduction|positive regulation of bone resorption|metal ion binding|positive regulation of ruffle assembly DEGS1 4381.1251401468 4583.39073230285 4178.85954799075 0.911739756014899 -0.133306009845611 0.315062184759229 1 72.06 77.1594 68.3321 67.8979 GeneID:8560,Genbank:NM_001321541.1,HGNC:HGNC:13709,MIM:615843 delta 4-desaturase, sphingolipid 1 GO:0005739,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0006636,GO:0009055,GO:0016020,GO:0030148,GO:0035579,GO:0042284,GO:0043312,GO:0046513 mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|unsaturated fatty acid biosynthetic process|electron transfer activity|membrane|sphingolipid biosynthetic process|specific granule membrane|sphingolipid delta-4 desaturase activity|neutrophil degranulation|ceramide biosynthetic process hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway DEK 2052.5996591242 2190.68805456968 1914.51126367873 0.873931484532975 -0.194407916762354 0.506225368744194 1 22.01 17.6915 19.9544 14.7284 GeneID:7913,Genbank:NM_001134709.1,HGNC:HGNC:2768,MIM:125264 DEK proto-oncogene DELE1 971.863131826527 980.327428654041 963.398834999013 0.982731694370451 -0.0251305094885013 0.854070248484771 1 4.92171 5.48041 5.08507 5.42141 GeneID:9812,Genbank:NM_014773.4,HGNC:HGNC:28969,MIM:615741 DAP3 binding cell death enhancer 1 GO:0005739,GO:0008625,GO:0043281 mitochondrion|extrinsic apoptotic signaling pathway via death domain receptors|regulation of cysteine-type endopeptidase activity involved in apoptotic process DENND1A 533.752894257468 518.400146368934 549.105642146002 1.05923126371036 0.0830176097108059 0.65370806924543 1 1.38035 1.56831 1.63597 1.46905 GeneID:57706,Genbank:NM_001352965.1,HGNC:HGNC:29324,MIM:613633 DENN domain containing 1A GO:0005654,GO:0005829,GO:0006897,GO:0015031,GO:0017112,GO:0017124,GO:0030054,GO:0030136,GO:0030425,GO:0030665,GO:0032266,GO:0032456,GO:0032483,GO:0042734,GO:0043025,GO:0043231,GO:0043547,GO:0048488,GO:1901981 nucleoplasm|cytosol|endocytosis|protein transport|Rab guanyl-nucleotide exchange factor activity|SH3 domain binding|cell junction|clathrin-coated vesicle|dendrite|clathrin-coated vesicle membrane|phosphatidylinositol-3-phosphate binding|endocytic recycling|regulation of Rab protein signal transduction|presynaptic membrane|neuronal cell body|intracellular membrane-bounded organelle|positive regulation of GTPase activity|synaptic vesicle endocytosis|phosphatidylinositol phosphate binding DENND1B 39.1446126216356 39.5124701140597 38.7767551292115 0.981380182440519 -0.0271159563357748 0.984624009529087 1 0.0569791 0.0776854 0.0658724 0.0536418 GeneID:163486,Genbank:XM_011509248.2,HGNC:HGNC:28404,MIM:613292 DENN domain containing 1B GO:0005829,GO:0015031,GO:0016607,GO:0017112,GO:0030136,GO:0032456,GO:0035745,GO:0043547,GO:0050776,GO:0050852 cytosol|protein transport|nuclear speck|Rab guanyl-nucleotide exchange factor activity|clathrin-coated vesicle|endocytic recycling|T-helper 2 cell cytokine production|positive regulation of GTPase activity|regulation of immune response|T cell receptor signaling pathway DENND1C 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.010126 0.0106819 0.00998257 GeneID:79958,Genbank:NM_001290331.1,HGNC:HGNC:26225,MIM:613634 DENN domain containing 1C GO:0005829,GO:0017112,GO:0030136 cytosol|Rab guanyl-nucleotide exchange factor activity|clathrin-coated vesicle DENND2A 1136.58313808825 956.458008782185 1316.70826739432 1.37665036551978 0.46116219783179 0.00220176155022746 0.168724464059536 4.86288 5.21464 7.05271 7.22489 GeneID:27147,Genbank:XM_011516054.2,HGNC:HGNC:22212 DENN domain containing 2A GO:0005829,GO:0015031,GO:0015629,GO:0017112,GO:0042147 cytosol|protein transport|actin cytoskeleton|Rab guanyl-nucleotide exchange factor activity|retrograde transport, endosome to Golgi DENND2C 17.0666526781236 15.2304310802552 18.9028742759919 1.24112536121828 0.311648843811335 0.698842669014607 1 0.0823459 0.134691 0.150662 0.103322 GeneID:163259,Genbank:NM_198459.3,HGNC:HGNC:24748 DENN domain containing 2C GO:0017112 Rab guanyl-nucleotide exchange factor activity DENND2D 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0085643 0 0 GeneID:79961,Genbank:NM_001271833.1,HGNC:HGNC:26192,MIM:615111 DENN domain containing 2D GO:0005654,GO:0005829,GO:0017112 nucleoplasm|cytosol|Rab guanyl-nucleotide exchange factor activity DENND3 10.2720697399134 3.57457863775636 16.9695608420704 4.74728983797698 2.24710413383036 0.0974079445087271 1 0.0104124 0.0092991 0.1074 0.027352 GeneID:22898,Genbank:XM_005250841.4,HGNC:HGNC:29134,MIM:617503 DENN domain containing 3 GO:0005829,GO:0008333,GO:0017112,GO:0044257 cytosol|endosome to lysosome transport|Rab guanyl-nucleotide exchange factor activity|cellular protein catabolic process DENND4A 155.734123563585 160.720751529235 150.747495597935 0.937946681829165 -0.0924221807255462 0.832324397166709 1 0.421973 0.323792 0.445386 0.29783 GeneID:10260,Genbank:XM_005254121.4,HGNC:HGNC:24321,MIM:600382 DENN domain containing 4A GO:0003677,GO:0005634,GO:0005829,GO:0006351,GO:0006355,GO:0017112 DNA binding|nucleus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|Rab guanyl-nucleotide exchange factor activity DENND4B 1418.61784002388 1521.53060819665 1315.70507185111 0.864724682345045 -0.209687225306158 0.169363925977341 1 9.83467 11.1538 9.07648 9.589 GeneID:9909,Genbank:XM_005245679.2,HGNC:HGNC:29044 DENN domain containing 4B GO:0005634,GO:0005794,GO:0005829,GO:0017112,GO:0032483 nucleus|Golgi apparatus|cytosol|Rab guanyl-nucleotide exchange factor activity|regulation of Rab protein signal transduction DENND4C 391.519975831613 403.003044190638 380.036907472589 0.943012498170648 -0.0846512031711613 0.862446813697769 1 1.93047 1.53239 2.14618 1.20359 GeneID:55667,Genbank:NM_001330640.1,HGNC:HGNC:26079 DENN domain containing 4C GO:0005829,GO:0005886,GO:0015031,GO:0017112,GO:0030659,GO:0030904,GO:0032593,GO:0032869,GO:0072659 cytosol|plasma membrane|protein transport|Rab guanyl-nucleotide exchange factor activity|cytoplasmic vesicle membrane|retromer complex|insulin-responsive compartment|cellular response to insulin stimulus|protein localization to plasma membrane DENND5A 3177.67117421645 2719.67192603124 3635.67042240167 1.33680477693025 0.418788793838843 0.00200746494479751 0.159166131464737 17.4077 16.7276 23.5719 22.577 GeneID:23258,Genbank:NM_001348748.1,HGNC:HGNC:19344,MIM:617278 DENN domain containing 5A GO:0000139,GO:0005262,GO:0005802,GO:0005829,GO:0010977,GO:0017112,GO:0042147,GO:0050982 Golgi membrane|calcium channel activity|trans-Golgi network|cytosol|negative regulation of neuron projection development|Rab guanyl-nucleotide exchange factor activity|retrograde transport, endosome to Golgi|detection of mechanical stimulus DENND5B 467.860277080885 521.800203216457 413.920350945313 0.793254483984183 -0.334144323681783 0.117235579419133 1 1.69505 1.50833 1.48441 1.08718 GeneID:160518,Genbank:NM_144973.3,HGNC:HGNC:28338,MIM:617279 DENN domain containing 5B GO:0005262,GO:0005829,GO:0016020,GO:0016021,GO:0017112,GO:0050982 calcium channel activity|cytosol|membrane|integral component of membrane|Rab guanyl-nucleotide exchange factor activity|detection of mechanical stimulus DENND6A 975.188151908981 1045.03342002006 905.342883797897 0.866329120632826 -0.207012882290312 0.180293474917903 1 8.6962 8.57288 8.26088 6.77667 GeneID:201627,Genbank:XM_006713019.3,HGNC:HGNC:26635 DENN domain containing 6A GO:0005737,GO:0005829,GO:0017112,GO:0043231,GO:0055037,GO:2000049 cytoplasm|cytosol|Rab guanyl-nucleotide exchange factor activity|intracellular membrane-bounded organelle|recycling endosome|positive regulation of cell-cell adhesion mediated by cadherin DENND6B 35.8120376888659 37.6962633302851 33.9278120474466 0.900031171529647 -0.151953126520083 0.790397945231368 1 0.233205 0.168571 0.198789 0.169827 GeneID:414918,Genbank:XM_024452245.1,HGNC:HGNC:32690 DENN domain containing 6B GO:0005829,GO:0017112,GO:0055037 cytosol|Rab guanyl-nucleotide exchange factor activity|recycling endosome DENR 1516.05158942412 1518.11565768975 1513.98752115849 0.997280749651482 -0.0039283925581064 0.998904200608538 1 24.0914 23.4053 24.5496 23.2495 GeneID:8562,Genbank:NM_003677.4,HGNC:HGNC:2769,MIM:604550 density regulated re-initiation and release factor DEPDC1 642.496958235518 700.940737265369 584.053179205667 0.833241882165781 -0.263192737896837 0.42399314487658 1 5.08393 4.06864 4.52365 3.21317 GeneID:55635,Genbank:NM_017779.5,HGNC:HGNC:22949,MIM:612002 DEP domain containing 1 GO:0005096,GO:0005634,GO:0006351,GO:0007165,GO:0017053,GO:0035556,GO:0045892 GTPase activator activity|nucleus|transcription, DNA-templated|signal transduction|transcriptional repressor complex|intracellular signal transduction|negative regulation of transcription, DNA-templated DEPDC1B 797.052117928175 817.720792754421 776.383443101929 0.949448087881865 -0.0748389732938384 0.661136212852309 1 4.61659 4.27759 4.55846 4.0655 GeneID:55789,Genbank:NM_001145208.1,HGNC:HGNC:24902,MIM:616073 DEP domain containing 1B GO:0005096,GO:0005829,GO:0016477,GO:0030177,GO:0035556,GO:0051056 GTPase activator activity|cytosol|cell migration|positive regulation of Wnt signaling pathway|intracellular signal transduction|regulation of small GTPase mediated signal transduction DEPDC4 25.3935818073091 28.9808392995304 21.8063243150877 0.752439364840653 -0.410352767590834 0.496565297150831 1 0.172387 0.0977161 0.126694 0.0908251 GeneID:120863,Genbank:XM_017018783.1,HGNC:HGNC:22952 DEP domain containing 4 GO:0005622,GO:0007165,GO:0035556 intracellular|signal transduction|intracellular signal transduction DEPDC5 320.584183614294 316.945633547446 324.222733681142 1.02296008956567 0.0327498599328199 0.88639064395488 1 1.46793 1.44759 1.6018 1.57312 GeneID:9681,Genbank:NM_001242897.1,HGNC:HGNC:18423,MIM:614191 DEP domain containing 5 GO:0005096,GO:0005764,GO:0005765,GO:0005829,GO:0010506,GO:0032007,GO:0032403,GO:0034198,GO:0035556,GO:0048471,GO:1904262,GO:1990130 GTPase activator activity|lysosome|lysosomal membrane|cytosol|regulation of autophagy|negative regulation of TOR signaling|protein complex binding|cellular response to amino acid starvation|intracellular signal transduction|perinuclear region of cytoplasm|negative regulation of TORC1 signaling|GATOR1 complex hsa04150 mTOR signaling pathway DEPDC7 68.9446943245853 77.7948573956721 60.0945312534985 0.772474341688833 -0.37244108126588 0.299795481549602 1 1.19821 1.00624 1.05261 0.855179 GeneID:91614,Genbank:NM_001077242.1,HGNC:HGNC:29899,MIM:612294 DEP domain containing 7 GO:0005096,GO:0005829,GO:0007165,GO:0035556,GO:0051056 GTPase activator activity|cytosol|signal transduction|intracellular signal transduction|regulation of small GTPase mediated signal transduction DEPP1 148.051059104082 153.168783746881 142.933334461283 0.933175357045907 -0.099779885226077 0.79667913879895 1 2.57436 3.12541 2.13463 3.39316 GeneID:11067,Genbank:NM_007021.3,HGNC:HGNC:23355,MIM:611309 DEPP1, autophagy regulator GO:0005737 cytoplasm DEPTOR 30.6203618729259 31.6811363378499 29.5595874080019 0.933034317102023 -0.0999979503565018 0.867969039379209 1 0.128098 0.18736 0.150722 0.166236 GeneID:64798,Genbank:NM_022783.3,HGNC:HGNC:22953,MIM:612974 DEP domain containing MTOR interacting protein GO:0005622,GO:0005737,GO:0006469,GO:0032007,GO:0035556,GO:0045792,GO:2001236 intracellular|cytoplasm|negative regulation of protein kinase activity|negative regulation of TOR signaling|intracellular signal transduction|negative regulation of cell size|regulation of extrinsic apoptotic signaling pathway hsa04140,hsa04150 Autophagy - animal|mTOR signaling pathway DERA 522.928317976949 510.82754427551 535.029091678387 1.04737713867251 0.06678102022666 0.704248909129658 1 10.2279 10.2191 11.2648 10.3665 GeneID:51071,Genbank:NM_015954.3,HGNC:HGNC:24269 deoxyribose-phosphate aldolase GO:0004139,GO:0005576,GO:0005634,GO:0005829,GO:0006098,GO:0009264,GO:0016052,GO:0034774,GO:0043312,GO:0046121,GO:0046386,GO:0070062,GO:1904813 deoxyribose-phosphate aldolase activity|extracellular region|nucleus|cytosol|pentose-phosphate shunt|deoxyribonucleotide catabolic process|carbohydrate catabolic process|secretory granule lumen|neutrophil degranulation|deoxyribonucleoside catabolic process|deoxyribose phosphate catabolic process|extracellular exosome|ficolin-1-rich granule lumen hsa00030 Pentose phosphate pathway DERL1 2100.56788278627 2057.14581221472 2143.98995335782 1.04221584130179 0.0596540884887409 0.659021516639156 1 27.4598 26.6247 29.3071 27.5073 GeneID:79139,Genbank:NM_001330601.1,HGNC:HGNC:28454,MIM:608813 derlin 1 GO:0002020,GO:0004872,GO:0005769,GO:0005770,GO:0005783,GO:0005789,GO:0006457,GO:0006986,GO:0016020,GO:0016021,GO:0016032,GO:0016567,GO:0030176,GO:0030433,GO:0030968,GO:0030970,GO:0031398,GO:0031625,GO:0031648,GO:0032092,GO:0036502,GO:0036503,GO:0036513,GO:0042288,GO:0045184,GO:0051117,GO:0051260,GO:0055085,GO:0071712,GO:1990381 protease binding|receptor activity|early endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|response to unfolded protein|membrane|integral component of membrane|viral process|protein ubiquitination|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|protein destabilization|positive regulation of protein binding|Derlin-1-VIMP complex|ERAD pathway|Derlin-1 retrotranslocation complex|MHC class I protein binding|establishment of protein localization|ATPase binding|protein homooligomerization|transmembrane transport|ER-associated misfolded protein catabolic process|ubiquitin-specific protease binding hsa04141,hsa05014 Protein processing in endoplasmic reticulum|Amyotrophic lateral sclerosis (ALS) DERL2 1217.90136929141 1272.21076011591 1163.59197846692 0.914622022502708 -0.128752437744522 0.393628492980263 1 13.098 12.8965 12.0072 11.6748 GeneID:51009,Genbank:NM_001304777.1,HGNC:HGNC:17943,MIM:610304 derlin 2 GO:0001967,GO:0005769,GO:0005770,GO:0005783,GO:0005789,GO:0008284,GO:0016020,GO:0030176,GO:0030307,GO:0030433,GO:0030968,GO:0030970,GO:0044322,GO:1904153,GO:1904380 suckling behavior|early endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum membrane|positive regulation of cell proliferation|membrane|integral component of endoplasmic reticulum membrane|positive regulation of cell growth|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|endoplasmic reticulum quality control compartment|negative regulation of retrograde protein transport, ER to cytosol|endoplasmic reticulum mannose trimming hsa04141 Protein processing in endoplasmic reticulum DERL3 46.3822061194519 46.7194623193653 46.0449499195385 0.985562496519843 -0.020980736494839 0.959718593159996 1 0.288691 0.37637 0.519967 0.387603 GeneID:91319,Genbank:XM_011530506.3,HGNC:HGNC:14236,MIM:610305 derlin 3 GO:0018279,GO:0030176,GO:0030433,GO:0030968,GO:1904153 protein N-linked glycosylation via asparagine|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|negative regulation of retrograde protein transport, ER to cytosol hsa04141 Protein processing in endoplasmic reticulum DES 1.97842567374833 2.98845468642911 0.968396661067546 0.32404595775373 -1.62572965732849 0.555377186137041 1 0.018644 0.0807254 0 0.0322044 GeneID:1674,Genbank:NM_001927.3,HGNC:HGNC:2770,MIM:125660 desmin hsa05410,hsa05412,hsa05414 Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) DESI1 1251.71278108825 1194.44532868556 1308.98023349095 1.09588961675746 0.132102490473147 0.373745538168115 1 8.87363 9.14025 10.3629 10.0396 GeneID:27351,Genbank:NM_015704.2,HGNC:HGNC:24577,MIM:614637 desumoylating isopeptidase 1 GO:0005634,GO:0005737,GO:0008233,GO:0042802 nucleus|cytoplasm|peptidase activity|identical protein binding DESI2 1065.53375087578 1126.92031941906 1004.1471823325 0.891054287538396 -0.166414764176595 0.291530063745192 1 9.43272 8.24348 8.09942 7.82162 GeneID:51029,Genbank:XM_011544203.3,HGNC:HGNC:24264,MIM:614638 desumoylating isopeptidase 2 GO:0005737,GO:0008233 cytoplasm|peptidase activity DET1 162.570808080277 152.120997358066 173.020618802489 1.13738814369741 0.185724670614226 0.448786536898726 1 2.32472 2.06475 2.91996 2.56203 GeneID:55070,Genbank:NM_001144074.2,HGNC:HGNC:25477,MIM:608727 DET1, COP1 ubiquitin ligase partner GO:0005634,GO:0006461,GO:0016567,GO:0031464,GO:0031625,GO:0032403,GO:0032436,GO:0080008,GO:1990756 nucleus|protein complex assembly|protein ubiquitination|Cul4A-RING E3 ubiquitin ligase complex|ubiquitin protein ligase binding|protein complex binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|Cul4-RING E3 ubiquitin ligase complex|protein binding, bridging involved in substrate recognition for ubiquitination hsa04120 Ubiquitin mediated proteolysis DEUP1 2.6878880617102 3.9205712156589 1.45520490776151 0.37117165528058 -1.4298415523839 0.64717293182397 1 0 0.0246967 0.0122434 0 GeneID:159989,Genbank:XM_011542631.2,HGNC:HGNC:26344,MIM:617148 deuterosome assembly protein 1 GO:0005814,GO:0007099,GO:0030030,GO:0042802,GO:0098535,GO:0098536,GO:1903251 centriole|centriole replication|cell projection organization|identical protein binding|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation|deuterosome|multi-ciliated epithelial cell differentiation DEXI 347.293460243857 319.492043106602 375.094877381111 1.17403511440802 0.231475558894908 0.233734712474912 1 8.84596 9.24868 10.4343 10.276 GeneID:28955,Genbank:NM_014015.3,HGNC:HGNC:13267,MIM:627901 Dexi homolog DFFA 1316.3972210564 1338.33319876143 1294.46124335137 0.967218959037508 -0.0480855708944959 0.71950514457112 1 12.4827 13.4399 13.1006 12.2622 GeneID:1676,Genbank:NM_004401.2,HGNC:HGNC:2772,MIM:601882 DNA fragmentation factor subunit alpha GO:0000790,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006309,GO:0019904,GO:0032076,GO:0043065,GO:0044183,GO:0060703,GO:0061077,GO:0070242,GO:1900118,GO:1902511 nuclear chromatin|nucleus|nucleoplasm|cytosol|plasma membrane|apoptotic DNA fragmentation|protein domain specific binding|negative regulation of deoxyribonuclease activity|positive regulation of apoptotic process|protein binding involved in protein folding|deoxyribonuclease inhibitor activity|chaperone-mediated protein folding|thymocyte apoptotic process|negative regulation of execution phase of apoptosis|negative regulation of apoptotic DNA fragmentation hsa04210 Apoptosis DFFB 140.438165579148 151.976918534011 128.899412624284 0.848151244726271 -0.237606541702221 0.367523795579341 1 1.98864 1.81983 1.45291 1.75544 GeneID:1677,Genbank:NM_001282669.1,HGNC:HGNC:2773,MIM:601883 DNA fragmentation factor subunit beta GO:0000790,GO:0004536,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006308,GO:0006309,GO:0019899,GO:0019904,GO:0030263,GO:0042802,GO:0051260,GO:0097718 nuclear chromatin|deoxyribonuclease activity|nucleus|nucleoplasm|nucleolus|cytosol|DNA catabolic process|apoptotic DNA fragmentation|enzyme binding|protein domain specific binding|apoptotic chromosome condensation|identical protein binding|protein homooligomerization|disordered domain specific binding hsa04210 Apoptosis DGAT1 613.896150676901 619.583143888758 608.209157465045 0.981642517980192 -0.026730356939183 0.870867370329967 1 7.14987 6.90156 7.10461 6.47916 GeneID:8694,Genbank:NM_012079.5,HGNC:HGNC:2843,MIM:604900 diacylglycerol O-acyltransferase 1 GO:0003846,GO:0004144,GO:0005789,GO:0005886,GO:0006641,GO:0016021,GO:0016746,GO:0019432,GO:0019915,GO:0034379,GO:0035336,GO:0035579,GO:0036155,GO:0043312,GO:0046339,GO:0050252,GO:0055089 2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity|endoplasmic reticulum membrane|plasma membrane|triglyceride metabolic process|integral component of membrane|transferase activity, transferring acyl groups|triglyceride biosynthetic process|lipid storage|very-low-density lipoprotein particle assembly|long-chain fatty-acyl-CoA metabolic process|specific granule membrane|acylglycerol acyl-chain remodeling|neutrophil degranulation|diacylglycerol metabolic process|retinol O-fatty-acyltransferase activity|fatty acid homeostasis hsa00561,hsa00830,hsa04975 Glycerolipid metabolism|Retinol metabolism|Fat digestion and absorption DGAT2 42.5285997771499 48.7179655467718 36.3392340075281 0.745910335123508 -0.422925878411387 0.340040606092147 1 0.774917 0.774939 0.39006 0.663792 GeneID:84649,Genbank:NM_032564.4,HGNC:HGNC:16940,MIM:606983 diacylglycerol O-acyltransferase 2 GO:0003846,GO:0004144,GO:0005739,GO:0005783,GO:0005789,GO:0005811,GO:0006071,GO:0010867,GO:0016021,GO:0019432,GO:0019915,GO:0030176,GO:0034383,GO:0035336,GO:0035356,GO:0036155,GO:0042632,GO:0042803,GO:0045722,GO:0046322,GO:0046339,GO:0048471,GO:0050252,GO:0050746,GO:0055089,GO:0060613,GO:0071400,GO:0090181,GO:0097006 2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|glycerol metabolic process|positive regulation of triglyceride biosynthetic process|integral component of membrane|triglyceride biosynthetic process|lipid storage|integral component of endoplasmic reticulum membrane|low-density lipoprotein particle clearance|long-chain fatty-acyl-CoA metabolic process|cellular triglyceride homeostasis|acylglycerol acyl-chain remodeling|cholesterol homeostasis|protein homodimerization activity|positive regulation of gluconeogenesis|negative regulation of fatty acid oxidation|diacylglycerol metabolic process|perinuclear region of cytoplasm|retinol O-fatty-acyltransferase activity|regulation of lipoprotein metabolic process|fatty acid homeostasis|fat pad development|cellular response to oleic acid|regulation of cholesterol metabolic process|regulation of plasma lipoprotein particle levels hsa00561,hsa04975 Glycerolipid metabolism|Fat digestion and absorption DGAT2L6 2.93248877666219 4.41064261761626 1.45433493570811 0.32973311641697 -1.60062930496355 0.587418397172247 1 0 0.202232 0.0458426 0.0214208 GeneID:347516,Genbank:NM_198512.2,HGNC:HGNC:23250,MIM:300926 diacylglycerol O-acyltransferase 2 like 6 GO:0004144,GO:0005789,GO:0016021,GO:0036155 diacylglycerol O-acyltransferase activity|endoplasmic reticulum membrane|integral component of membrane|acylglycerol acyl-chain remodeling DGCR2 2223.09574197986 2034.14493329062 2412.0465506691 1.18577910118093 0.245835275218391 0.0821092286824298 0.960511097314172 20.8448 21.4682 26.9316 24.5447 GeneID:9993,Genbank:NM_001173534.1,HGNC:HGNC:2845,MIM:600594 DiGeorge syndrome critical region gene 2 GO:0007155,GO:0009887,GO:0016021,GO:0030246,GO:0050890 cell adhesion|animal organ morphogenesis|integral component of membrane|carbohydrate binding|cognition DGCR6 146.953179536974 130.116827545524 163.789531528425 1.25878823375954 0.332035598543939 0.313485996754042 1 3.06975 4.54932 4.69022 5.44014 GeneID:8214,Genbank:NM_005675.4,HGNC:HGNC:2846,MIM:601279 DiGeorge syndrome critical region gene 6 GO:0005578,GO:0005634,GO:0007155,GO:0009887 proteinaceous extracellular matrix|nucleus|cell adhesion|animal organ morphogenesis DGCR6L 884.115021537901 879.970686458969 888.259356616832 1.00941925712459 0.013525514924276 0.967564738211864 1 29.878 32.7859 30.8157 33.7265 GeneID:85359,Genbank:NM_033257.3,HGNC:HGNC:18551,MIM:609459 DiGeorge syndrome critical region gene 6 like GO:0005634 nucleus DGCR8 1348.03523435114 1334.29695768618 1361.77351101609 1.02059253239815 0.0294069907782978 0.864022494600003 1 10.6444 11.8924 11.5694 11.6014 GeneID:54487,Genbank:NM_022720.6,HGNC:HGNC:2847,MIM:609030 DGCR8, microprocessor complex subunit GO:0003725,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0010586,GO:0014069,GO:0020037,GO:0031053,GO:0042802,GO:0042803,GO:0046872,GO:0070877,GO:0070878,GO:0072091,GO:0090502 double-stranded RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|miRNA metabolic process|postsynaptic density|heme binding|primary miRNA processing|identical protein binding|protein homodimerization activity|metal ion binding|microprocessor complex|primary miRNA binding|regulation of stem cell proliferation|RNA phosphodiester bond hydrolysis, endonucleolytic DGKA 263.489938785974 264.797168186972 262.182709384975 0.990126560567477 -0.0143151488535837 0.9465168186507 1 1.48304 1.5375 1.58169 1.60977 GeneID:1606,Genbank:XM_017018901.2,HGNC:HGNC:2849,MIM:125855 diacylglycerol kinase alpha GO:0003951,GO:0004143,GO:0005509,GO:0005524,GO:0005543,GO:0005829,GO:0005886,GO:0006654,GO:0007205,GO:0016020,GO:0016301,GO:0030168,GO:0035556,GO:0046339,GO:0046486,GO:0046834 NAD+ kinase activity|diacylglycerol kinase activity|calcium ion binding|ATP binding|phospholipid binding|cytosol|plasma membrane|phosphatidic acid biosynthetic process|protein kinase C-activating G-protein coupled receptor signaling pathway|membrane|kinase activity|platelet activation|intracellular signal transduction|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation hsa00561,hsa00564,hsa04070,hsa04072,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKB 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00401803 0 0 0 GeneID:1607,Genbank:NM_001350722.1,HGNC:HGNC:2850,MIM:604070 diacylglycerol kinase beta GO:0003951,GO:0004143,GO:0005509,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0007205,GO:0030168,GO:0035556,GO:0046486,GO:0046834 NAD+ kinase activity|diacylglycerol kinase activity|calcium ion binding|ATP binding|cytoplasm|cytosol|plasma membrane|protein kinase C-activating G-protein coupled receptor signaling pathway|platelet activation|intracellular signal transduction|glycerolipid metabolic process|lipid phosphorylation hsa00561,hsa00564,hsa04070,hsa04072,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKD 995.977525272593 977.607514305506 1014.34753623968 1.03758156662725 0.0532247544288533 0.738722152047891 1 3.30695 3.56671 3.78607 3.47978 GeneID:8527,Genbank:NM_152879.2,HGNC:HGNC:2851,MIM:601826 diacylglycerol kinase delta GO:0003951,GO:0004143,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006897,GO:0007165,GO:0007173,GO:0007205,GO:0007275,GO:0010033,GO:0015031,GO:0016049,GO:0019932,GO:0019992,GO:0030168,GO:0031410,GO:0042802,GO:0042803,GO:0046339,GO:0046834,GO:0046872,GO:0046982,GO:0051260 NAD+ kinase activity|diacylglycerol kinase activity|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|endocytosis|signal transduction|epidermal growth factor receptor signaling pathway|protein kinase C-activating G-protein coupled receptor signaling pathway|multicellular organism development|response to organic substance|protein transport|cell growth|second-messenger-mediated signaling|diacylglycerol binding|platelet activation|cytoplasmic vesicle|identical protein binding|protein homodimerization activity|diacylglycerol metabolic process|lipid phosphorylation|metal ion binding|protein heterodimerization activity|protein homooligomerization hsa00561,hsa00564,hsa04070,hsa04072,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKE 12.8885845348942 13.1740929230559 12.6030761467324 0.95665608405387 -0.0639277229499282 0.97128269570717 1 0.0419577 0.080821 0.0506705 0.0329695 GeneID:8526,Genbank:NM_003647.2,HGNC:HGNC:2852,MIM:601440 diacylglycerol kinase epsilon GO:0003951,GO:0004143,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007205,GO:0008654,GO:0016020,GO:0016021,GO:0016301,GO:0030168,GO:0035556,GO:0046834,GO:0046872 NAD+ kinase activity|diacylglycerol kinase activity|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein kinase C-activating G-protein coupled receptor signaling pathway|phospholipid biosynthetic process|membrane|integral component of membrane|kinase activity|platelet activation|intracellular signal transduction|lipid phosphorylation|metal ion binding hsa00561,hsa00564,hsa04070,hsa04072,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKG 228.013306016416 234.547011434563 221.479600598269 0.944286602688435 -0.0827032930091792 0.760147981285342 1 1.36993 1.01314 1.20556 1.03181 GeneID:1608,Genbank:NM_001080745.1,HGNC:HGNC:2853,MIM:601854 diacylglycerol kinase gamma GO:0003951,GO:0004143,GO:0005509,GO:0005524,GO:0005737,GO:0005886,GO:0007165,GO:0007205,GO:0030168,GO:0035556,GO:0046486,GO:0046834,GO:0048666 NAD+ kinase activity|diacylglycerol kinase activity|calcium ion binding|ATP binding|cytoplasm|plasma membrane|signal transduction|protein kinase C-activating G-protein coupled receptor signaling pathway|platelet activation|intracellular signal transduction|glycerolipid metabolic process|lipid phosphorylation|neuron development hsa00561,hsa00564,hsa04070,hsa04072,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKH 91.855536126653 90.6327663959334 93.0783058573726 1.0269829506335 0.0384122310809685 0.957151978538707 1 0.1923 0.206276 0.264333 0.12538 GeneID:160851,Genbank:NM_001204504.2,HGNC:HGNC:2854,MIM:604071 diacylglycerol kinase eta GO:0003951,GO:0004143,GO:0005524,GO:0005737,GO:0005768,GO:0005886,GO:0007205,GO:0030168,GO:0035556,GO:0046473,GO:0046872,GO:0051259 NAD+ kinase activity|diacylglycerol kinase activity|ATP binding|cytoplasm|endosome|plasma membrane|protein kinase C-activating G-protein coupled receptor signaling pathway|platelet activation|intracellular signal transduction|phosphatidic acid metabolic process|metal ion binding|protein oligomerization hsa00561,hsa00564,hsa04070,hsa04072,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKI 24.914445109251 14.4423933750803 35.3864968434217 2.45018231565964 1.29288910274297 0.0249876360786538 0.631315976879816 0.0542439 0.0479092 0.168671 0.0858886 GeneID:9162,Genbank:XM_017012780.2,HGNC:HGNC:2855,MIM:604072 diacylglycerol kinase iota GO:0003951,GO:0004143,GO:0005095,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007205,GO:0007269,GO:0008021,GO:0014069,GO:0017016,GO:0030168,GO:0032045,GO:0035556,GO:0043025,GO:0043197,GO:0043234,GO:0043679,GO:0045202,GO:0046579,GO:0046834,GO:0046872,GO:0046959,GO:0048471,GO:0048786,GO:0051966,GO:0060076,GO:0060079,GO:0097060,GO:1900452 NAD+ kinase activity|diacylglycerol kinase activity|GTPase inhibitor activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein kinase C-activating G-protein coupled receptor signaling pathway|neurotransmitter secretion|synaptic vesicle|postsynaptic density|Ras GTPase binding|platelet activation|guanyl-nucleotide exchange factor complex|intracellular signal transduction|neuronal cell body|dendritic spine|protein complex|axon terminus|synapse|positive regulation of Ras protein signal transduction|lipid phosphorylation|metal ion binding|habituation|perinuclear region of cytoplasm|presynaptic active zone|regulation of synaptic transmission, glutamatergic|excitatory synapse|excitatory postsynaptic potential|synaptic membrane|regulation of long term synaptic depression hsa00561,hsa00564,hsa04070,hsa04072,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKK 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.00490852 0.00502312 0 GeneID:139189,Genbank:NM_001013742.3,HGNC:HGNC:32395,MIM:300837 diacylglycerol kinase kappa GO:0003951,GO:0004143,GO:0005524,GO:0005737,GO:0005886,GO:0006979,GO:0007205,GO:0030168,GO:0035556,GO:0046339,GO:0046872 NAD+ kinase activity|diacylglycerol kinase activity|ATP binding|cytoplasm|plasma membrane|response to oxidative stress|protein kinase C-activating G-protein coupled receptor signaling pathway|platelet activation|intracellular signal transduction|diacylglycerol metabolic process|metal ion binding hsa00561,hsa00564,hsa04070,hsa04072,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKQ 514.875099468298 488.919427012339 540.830771924258 1.10617566421759 0.145580508331914 0.417233755838119 1 4.4285 4.53931 5.10177 5.13531 GeneID:1609,Genbank:NM_001347.3,HGNC:HGNC:2856,MIM:601207 diacylglycerol kinase theta GO:0003951,GO:0004143,GO:0005524,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0005856,GO:0005886,GO:0006111,GO:0006357,GO:0006654,GO:0007186,GO:0007205,GO:0008277,GO:0010628,GO:0010629,GO:0010801,GO:0012506,GO:0016363,GO:0016607,GO:0018105,GO:0019900,GO:0019933,GO:0030168,GO:0030297,GO:0033198,GO:0033613,GO:0043274,GO:0046339,GO:0046486,GO:0046834,GO:0046872,GO:0050731,GO:0051591,GO:0070493,GO:0070528,GO:0090181,GO:1903432,GO:2000064,GO:2000182 NAD+ kinase activity|diacylglycerol kinase activity|ATP binding|nucleus|cytoplasm|endosome|cytosol|cytoskeleton|plasma membrane|regulation of gluconeogenesis|regulation of transcription from RNA polymerase II promoter|phosphatidic acid biosynthetic process|G-protein coupled receptor signaling pathway|protein kinase C-activating G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|positive regulation of gene expression|negative regulation of gene expression|negative regulation of peptidyl-threonine phosphorylation|vesicle membrane|nuclear matrix|nuclear speck|peptidyl-serine phosphorylation|kinase binding|cAMP-mediated signaling|platelet activation|transmembrane receptor protein tyrosine kinase activator activity|response to ATP|activating transcription factor binding|phospholipase binding|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|response to cAMP|thrombin-activated receptor signaling pathway|protein kinase C signaling|regulation of cholesterol metabolic process|regulation of TORC1 signaling|regulation of cortisol biosynthetic process|regulation of progesterone biosynthetic process hsa00561,hsa00564,hsa04070,hsa04072,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGKZ 1664.24630550142 1614.88227194027 1713.61033906257 1.06113638674334 0.0856100962458443 0.572446604762323 1 7.4411 8.47724 9.15404 9.43912 GeneID:8525,Genbank:NM_201532.2,HGNC:HGNC:2857,MIM:601441 diacylglycerol kinase zeta GO:0001727,GO:0003951,GO:0004143,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0007205,GO:0008022,GO:0016301,GO:0016477,GO:0016607,GO:0030027,GO:0030168,GO:0031571,GO:0035556,GO:0045930,GO:0046339,GO:0046486,GO:0046834,GO:0046872 lipid kinase activity|NAD+ kinase activity|diacylglycerol kinase activity|ATP binding|nucleus|cytoplasm|plasma membrane|protein kinase C-activating G-protein coupled receptor signaling pathway|protein C-terminus binding|kinase activity|cell migration|nuclear speck|lamellipodium|platelet activation|mitotic G1 DNA damage checkpoint|intracellular signal transduction|negative regulation of mitotic cell cycle|diacylglycerol metabolic process|glycerolipid metabolic process|lipid phosphorylation|metal ion binding hsa00561,hsa00564,hsa04070,hsa04072,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Choline metabolism in cancer DGLUCY 324.973776067873 308.768307193333 341.179244942412 1.10496847310428 0.144005207313567 0.472748964600751 1 1.77026 1.88042 2.21893 2.1068 GeneID:80017,Genbank:NM_001358312.1,HGNC:HGNC:20498 D-glutamate cyclase GO:0005759,GO:0006536,GO:0047820 mitochondrial matrix|glutamate metabolic process|D-glutamate cyclase activity hsa00471 D-Glutamine and D-glutamate metabolism DGUOK 920.040257625745 926.641105502795 913.439409748695 0.985753172748648 -0.0207016460834365 0.897447833586805 1 17.6432 18.7017 15.3108 19.3267 GeneID:1716,Genbank:NM_001318861.1,HGNC:HGNC:2858,MIM:601465 deoxyguanosine kinase GO:0004138,GO:0005524,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0006468,GO:0008617,GO:0010977,GO:0019206,GO:0043101,GO:0046070,GO:0046122 deoxyguanosine kinase activity|ATP binding|nucleus|mitochondrion|mitochondrial matrix|cytosol|protein phosphorylation|guanosine metabolic process|negative regulation of neuron projection development|nucleoside kinase activity|purine-containing compound salvage|dGTP metabolic process|purine deoxyribonucleoside metabolic process hsa00230 Purine metabolism DHCR24 24466.6013512271 21939.1198924938 26994.0828099603 1.23040864639224 0.299137546630332 0.0207152797567505 0.588255178340632 200.068 206.487 251.929 254.194 GeneID:1718,Genbank:NM_014762.3,HGNC:HGNC:2859,MIM:606418 24-dehydrocholesterol reductase GO:0000139,GO:0000246,GO:0005634,GO:0005783,GO:0005789,GO:0005829,GO:0005856,GO:0006695,GO:0006915,GO:0006979,GO:0007050,GO:0007265,GO:0008104,GO:0008285,GO:0009725,GO:0009888,GO:0016020,GO:0016021,GO:0016614,GO:0016628,GO:0019899,GO:0030539,GO:0031639,GO:0033489,GO:0033490,GO:0042605,GO:0042987,GO:0043066,GO:0043154,GO:0043588,GO:0050614,GO:0050660,GO:0055114,GO:0061024,GO:1901214 Golgi membrane|delta24(24-1) sterol reductase activity|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|cytoskeleton|cholesterol biosynthetic process|apoptotic process|response to oxidative stress|cell cycle arrest|Ras protein signal transduction|protein localization|negative regulation of cell proliferation|response to hormone|tissue development|membrane|integral component of membrane|oxidoreductase activity, acting on CH-OH group of donors|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|enzyme binding|male genitalia development|plasminogen activation|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|peptide antigen binding|amyloid precursor protein catabolic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|skin development|delta24-sterol reductase activity|flavin adenine dinucleotide binding|oxidation-reduction process|membrane organization|regulation of neuron death hsa00100 Steroid biosynthesis DHCR7 2477.89775832329 2392.26535625673 2563.53016038984 1.07159105643744 0.0997544455247351 0.485181087638944 1 37.9294 39.2887 39.9919 43.719 GeneID:1717,Genbank:NM_001163817.1,HGNC:HGNC:2860,MIM:602858 7-dehydrocholesterol reductase GO:0001568,GO:0005640,GO:0005783,GO:0005789,GO:0005829,GO:0006695,GO:0009791,GO:0009918,GO:0016020,GO:0016132,GO:0030154,GO:0030176,GO:0030324,GO:0033489,GO:0033490,GO:0035264,GO:0042127,GO:0045540,GO:0047598,GO:0050661 blood vessel development|nuclear outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|cholesterol biosynthetic process|post-embryonic development|sterol delta7 reductase activity|membrane|brassinosteroid biosynthetic process|cell differentiation|integral component of endoplasmic reticulum membrane|lung development|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|multicellular organism growth|regulation of cell proliferation|regulation of cholesterol biosynthetic process|7-dehydrocholesterol reductase activity|NADP binding hsa00100 Steroid biosynthesis DHDDS 939.755684337919 909.325927300871 970.185441374967 1.06692816321068 0.0934630420773848 0.561549796147052 1 9.57523 10.3377 10.3067 11.2876 GeneID:79947,Genbank:NM_001319959.1,HGNC:HGNC:20603,MIM:608172 dehydrodolichyl diphosphate synthase subunit GO:0005789,GO:0006486,GO:0006489,GO:0016094,GO:0016765 endoplasmic reticulum membrane|protein glycosylation|dolichyl diphosphate biosynthetic process|polyprenol biosynthetic process|transferase activity, transferring alkyl or aryl (other than methyl) groups hsa00900 Terpenoid backbone biosynthesis DHDH 11.7934779154535 12.9241528945232 10.6628029363838 0.825029154591807 -0.277482993175165 0.794728564447614 1 0.266402 0.1055 0.194044 0.103579 GeneID:27294,Genbank:XM_005258748.4,HGNC:HGNC:17887,MIM:606377 dihydrodiol dehydrogenase GO:0005975,GO:0008746,GO:0009055,GO:0042843,GO:0047115,GO:0047837 carbohydrate metabolic process|NAD(P)+ transhydrogenase activity|electron transfer activity|D-xylose catabolic process|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|D-xylose 1-dehydrogenase (NADP+) activity hsa00040,hsa00980 Pentose and glucuronate interconversions|Metabolism of xenobiotics by cytochrome P450 DHFR 3446.83400493342 3536.80659483434 3356.8614150325 0.949122131794074 -0.0753343515855145 0.589143103633318 1 33.8865 33.1355 30.8977 32.965 GeneID:1719,Genbank:NM_001290354.1,HGNC:HGNC:2861,MIM:126060 dihydrofolate reductase hsa00670,hsa00790,hsa01523 One carbon pool by folate|Folate biosynthesis|Antifolate resistance DHFR2 135.045743748323 132.441706040617 137.649781456028 1.03932353011078 0.0556448194307069 0.843842128836515 1 1.14455 1.10557 1.34229 1.00933 GeneID:200895,Genbank:XM_011512537.3,HGNC:HGNC:27309,MIM:616588 dihydrofolate reductase 2 GO:0003729,GO:0004146,GO:0005739,GO:0005743,GO:0005759,GO:0006545,GO:0006730,GO:0009165,GO:0046105,GO:0046653,GO:0046654,GO:0050661 mRNA binding|dihydrofolate reductase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|glycine biosynthetic process|one-carbon metabolic process|nucleotide biosynthetic process|thymidine biosynthetic process|tetrahydrofolate metabolic process|tetrahydrofolate biosynthetic process|NADP binding hsa00670,hsa00790,hsa01523 One carbon pool by folate|Folate biosynthesis|Antifolate resistance DHH 2.93638115004879 1.02816907859967 4.84459322149792 4.71186434442874 2.23629800427084 0.285753015024831 1 0.0100456 0.0089495 0.028215 0.0614621 GeneID:50846,Genbank:NM_021044.3,HGNC:HGNC:2865,MIM:605423 desert hedgehog GO:0001649,GO:0005113,GO:0005509,GO:0005615,GO:0005886,GO:0007224,GO:0007267,GO:0007286,GO:0008233,GO:0008270,GO:0030238,GO:0032355,GO:0033327,GO:0042552,GO:0043627,GO:0050810 osteoblast differentiation|patched binding|calcium ion binding|extracellular space|plasma membrane|smoothened signaling pathway|cell-cell signaling|spermatid development|peptidase activity|zinc ion binding|male sex determination|response to estradiol|Leydig cell differentiation|myelination|response to estrogen|regulation of steroid biosynthetic process hsa04340 Hedgehog signaling pathway DHODH 343.023620033353 388.47542392215 297.571816144557 0.765999076956255 -0.38458544121159 0.0446753228718143 0.787153801689864 3.76151 3.71974 3.31536 2.67839 GeneID:1723,Genbank:NM_001361.4,HGNC:HGNC:2867,MIM:126064 dihydroorotate dehydrogenase (quinone) GO:0004152,GO:0005654,GO:0005739,GO:0005743,GO:0005829,GO:0006207,GO:0007565,GO:0007595,GO:0008144,GO:0010181,GO:0016021,GO:0031000,GO:0042594,GO:0043025,GO:0043065,GO:0044205,GO:0046134,GO:0048039,GO:0090140,GO:1903576 dihydroorotate dehydrogenase activity|nucleoplasm|mitochondrion|mitochondrial inner membrane|cytosol|'de novo' pyrimidine nucleobase biosynthetic process|female pregnancy|lactation|drug binding|FMN binding|integral component of membrane|response to caffeine|response to starvation|neuronal cell body|positive regulation of apoptotic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process|ubiquinone binding|regulation of mitochondrial fission|response to L-arginine hsa00240 Pyrimidine metabolism DHPS 1879.7849642195 1991.76069535057 1767.80923308843 0.887561059526421 -0.17208172214795 0.315201533565322 1 29.2221 31.8803 24.9568 28.4819 GeneID:1725,Genbank:XM_011527770.2,HGNC:HGNC:2869,MIM:600944 deoxyhypusine synthase GO:0005737,GO:0005829,GO:0006412,GO:0008216,GO:0008284,GO:0008612,GO:0034038,GO:0042102,GO:0042593,GO:0042802,GO:0046203,GO:0051289 cytoplasm|cytosol|translation|spermidine metabolic process|positive regulation of cell proliferation|peptidyl-lysine modification to peptidyl-hypusine|deoxyhypusine synthase activity|positive regulation of T cell proliferation|glucose homeostasis|identical protein binding|spermidine catabolic process|protein homotetramerization DHRS1 253.841298614791 241.639350781137 266.043246448444 1.10099305261505 0.138805365369644 0.523483134165467 1 5.31736 5.48779 5.41387 6.5361 GeneID:115817,Genbank:NM_001136050.2,HGNC:HGNC:16445,MIM:610410 dehydrogenase/reductase 1 GO:0005743,GO:0005783,GO:0016491 mitochondrial inner membrane|endoplasmic reticulum|oxidoreductase activity DHRS11 424.656383226496 356.938366408355 492.374400044638 1.37943815062273 0.464080772537342 0.0106859850491929 0.413666579021508 8.68142 8.33593 11.7996 11.2499 GeneID:79154,Genbank:NM_024308.3,HGNC:HGNC:28639,MIM:616159 dehydrogenase/reductase 11 GO:0000166,GO:0000253,GO:0004303,GO:0005576,GO:0006694,GO:0006703,GO:0072555,GO:0072582 nucleotide binding|3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity|extracellular region|steroid biosynthetic process|estrogen biosynthetic process|17-beta-ketosteroid reductase activity|17-beta-hydroxysteroid dehydrogenase (NADP+) activity hsa00140 Steroid hormone biosynthesis DHRS12 106.556262514435 107.467681851008 105.644843177862 0.983038261905822 -0.0246805245193541 0.959925413256664 1 0.940775 0.851644 0.927617 0.836378 GeneID:79758,Genbank:NM_024705.2,HGNC:HGNC:25832,MIM:616163 dehydrogenase/reductase 12 GO:0016491 oxidoreductase activity DHRS13 461.173489891247 426.604940725454 495.74203905704 1.1620635199724 0.216688930570802 0.296846367893305 1 9.79874 11.3255 12.0481 13.2551 GeneID:147015,Genbank:NM_144683.3,HGNC:HGNC:28326,MIM:616157 dehydrogenase/reductase 13 GO:0005576,GO:0016020,GO:0016491 extracellular region|membrane|oxidoreductase activity DHRS2 43.9762141702347 51.1202962818737 36.8321320585958 0.720499189901132 -0.472931286591817 0.27103128170608 1 0.593998 0.728683 0.423946 0.506232 GeneID:10202,Genbank:XM_005267249.1,HGNC:HGNC:18349,MIM:615194 dehydrogenase/reductase 2 GO:0004090,GO:0005634,GO:0005635,GO:0005737,GO:0005739,GO:0005759,GO:0008207,GO:0008285,GO:0009636,GO:0034599,GO:0043011,GO:0043066,GO:0055114,GO:0070062 carbonyl reductase (NADPH) activity|nucleus|nuclear envelope|cytoplasm|mitochondrion|mitochondrial matrix|C21-steroid hormone metabolic process|negative regulation of cell proliferation|response to toxic substance|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptotic process|oxidation-reduction process|extracellular exosome DHRS3 2158.23140592152 2181.3476333206 2135.11517852244 0.978805553919076 -0.0309058073352249 0.840422525985023 1 31.3523 35.3636 30.8782 34.1233 GeneID:9249,Genbank:NM_004753.6,HGNC:HGNC:17693,MIM:612830 dehydrogenase/reductase 3 GO:0000166,GO:0001523,GO:0003151,GO:0004745,GO:0005789,GO:0007601,GO:0009055,GO:0016021,GO:0030278,GO:0042572,GO:0042622,GO:0048387,GO:0052650,GO:0060021,GO:0060349,GO:0060411 nucleotide binding|retinoid metabolic process|outflow tract morphogenesis|retinol dehydrogenase activity|endoplasmic reticulum membrane|visual perception|electron transfer activity|integral component of membrane|regulation of ossification|retinol metabolic process|photoreceptor outer segment membrane|negative regulation of retinoic acid receptor signaling pathway|NADP-retinol dehydrogenase activity|palate development|bone morphogenesis|cardiac septum morphogenesis hsa00830 Retinol metabolism DHRS4 195.215721966275 168.005195974549 222.426247958002 1.32392481475214 0.404821194302118 0.083614064014454 0.963076417285947 3.78464 3.8509 4.61811 4.79749 GeneID:10901,Genbank:NM_021004.3,HGNC:HGNC:16985,MIM:611596 dehydrogenase/reductase 4 GO:0000253,GO:0004090,GO:0005102,GO:0005634,GO:0005739,GO:0005777,GO:0005778,GO:0005789,GO:0006066,GO:0008202,GO:0016655,GO:0018455,GO:0042180,GO:0051262,GO:0052650,GO:0055114,GO:0070062 3-keto sterol reductase activity|carbonyl reductase (NADPH) activity|receptor binding|nucleus|mitochondrion|peroxisome|peroxisomal membrane|endoplasmic reticulum membrane|alcohol metabolic process|steroid metabolic process|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|alcohol dehydrogenase [NAD(P)+] activity|cellular ketone metabolic process|protein tetramerization|NADP-retinol dehydrogenase activity|oxidation-reduction process|extracellular exosome hsa00830,hsa04146 Retinol metabolism|Peroxisome DHRS4L1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0274484 0 0 GeneID:728635,Genbank:NM_001277864.1,HGNC:HGNC:19732,MIM:615195 dehydrogenase/reductase 4 like 1 GO:0016491 oxidoreductase activity hsa00830,hsa04146 Retinol metabolism|Peroxisome DHRS4L2 96.9458669553961 75.6620839993188 118.229649911474 1.56260102368497 0.643949464435775 0.146022300441657 1 1.50509 2.24028 2.53644 3.57755 GeneID:317749,Genbank:NM_001193636.1,HGNC:HGNC:19731,MIM:615196 dehydrogenase/reductase 4 like 2 GO:0005576,GO:0016491 extracellular region|oxidoreductase activity hsa00830 Retinol metabolism DHRS7 834.388854579586 780.016754770738 888.760954388434 1.13941264588561 0.188290323305771 0.242136836226653 1 7.98964 9.1339 9.54117 10.2979 GeneID:51635,Genbank:NM_001322282.1,HGNC:HGNC:21524,MIM:612833 dehydrogenase/reductase 7 GO:0016020,GO:0016491 membrane|oxidoreductase activity DHRS7B 665.935803058578 655.396573851223 676.475032265933 1.0321613802325 0.0456685562835357 0.831853695350805 1 6.77702 7.80274 6.4496 8.30771 GeneID:25979,Genbank:XM_017024426.2,HGNC:HGNC:24547,MIM:616160 dehydrogenase/reductase 7B GO:0005789,GO:0016020,GO:0016021,GO:0016491 endoplasmic reticulum membrane|membrane|integral component of membrane|oxidoreductase activity DHRS9 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:10170,Genbank:NM_199204.1,HGNC:HGNC:16888,MIM:612131 dehydrogenase/reductase 9 GO:0004022,GO:0004745,GO:0005789,GO:0008209,GO:0016854,GO:0030176,GO:0030855,GO:0031090,GO:0042448,GO:0042572,GO:0042904,GO:0047035 alcohol dehydrogenase (NAD) activity|retinol dehydrogenase activity|endoplasmic reticulum membrane|androgen metabolic process|racemase and epimerase activity|integral component of endoplasmic reticulum membrane|epithelial cell differentiation|organelle membrane|progesterone metabolic process|retinol metabolic process|9-cis-retinoic acid biosynthetic process|testosterone dehydrogenase (NAD+) activity hsa00830 Retinol metabolism DHRSX 20.677005647594 4.06465003971372 37.2893612554743 9.17406440680945 3.19756103594161 0.237929527880585 1 0.379549 0.0144338 0.0595193 0.831618 GeneID:207063,Genbank:NM_145177.2,HGNC:HGNC:18399 dehydrogenase/reductase X-linked GO:0005576,GO:0010508,GO:0016491 extracellular region|positive regulation of autophagy|oxidoreductase activity DHTKD1 1140.5451971726 1072.40098329052 1208.68941105467 1.12708719022801 0.172599125132132 0.254399375401272 1 7.44069 7.90254 9.20826 8.42962 GeneID:55526,Genbank:NM_018706.6,HGNC:HGNC:23537,MIM:614984 dehydrogenase E1 and transketolase domain containing 1 GO:0002244,GO:0004591,GO:0005739,GO:0005759,GO:0006091,GO:0006096,GO:0006099,GO:0030976,GO:0034641,GO:0045252 hematopoietic progenitor cell differentiation|oxoglutarate dehydrogenase (succinyl-transferring) activity|mitochondrion|mitochondrial matrix|generation of precursor metabolites and energy|glycolytic process|tricarboxylic acid cycle|thiamine pyrophosphate binding|cellular nitrogen compound metabolic process|oxoglutarate dehydrogenase complex DHX15 3139.55708659918 3448.72597864925 2830.38819454911 0.820705446611817 -0.285063567112373 0.0861472873560237 0.964561165794104 42.0984 35.3694 35.5717 29.6995 GeneID:1665,Genbank:NM_001358.2,HGNC:HGNC:2738,MIM:603403 DEAH-box helicase 15 GO:0000398,GO:0003723,GO:0003725,GO:0004004,GO:0005524,GO:0005681,GO:0005689,GO:0005730,GO:0005737,GO:0009636,GO:0016607,GO:0043279,GO:0071008 mRNA splicing, via spliceosome|RNA binding|double-stranded RNA binding|ATP-dependent RNA helicase activity|ATP binding|spliceosomal complex|U12-type spliceosomal complex|nucleolus|cytoplasm|response to toxic substance|nuclear speck|response to alkaloid|U2-type post-mRNA release spliceosomal complex hsa03040 Spliceosome DHX16 2053.4853251779 2046.32805775379 2060.642592602 1.00699522972085 0.0100568491099671 0.952631383773077 1 12.3943 12.2316 12.9464 12.3942 GeneID:8449,Genbank:NM_001164239.1,HGNC:HGNC:2739,MIM:603405 DEAH-box helicase 16 GO:0000398,GO:0003723,GO:0003724,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0008380,GO:0016887 mRNA splicing, via spliceosome|RNA binding|RNA helicase activity|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|RNA splicing|ATPase activity hsa03040 Spliceosome DHX29 339.938275262526 350.768334935902 329.10821558915 0.938249502051802 -0.0919564754426696 0.792106727162258 1 2.41708 1.9597 2.43482 1.76741 GeneID:54505,Genbank:NM_001345964.1,HGNC:HGNC:15815,MIM:612720 DExH-box helicase 29 GO:0003723,GO:0003743,GO:0004004,GO:0005524,GO:0005739,GO:0006396,GO:0016282,GO:0043024,GO:0045296 RNA binding|translation initiation factor activity|ATP-dependent RNA helicase activity|ATP binding|mitochondrion|RNA processing|eukaryotic 43S preinitiation complex|ribosomal small subunit binding|cadherin binding DHX30 4361.93447262519 4451.00010353948 4272.86884171089 0.959979497262439 -0.0589245010469747 0.640676714074529 1 34.147 36.0226 34.1368 34.2185 GeneID:22907,Genbank:NM_001330990.1,HGNC:HGNC:16716,MIM:616423 DExH-box helicase 30 GO:0003682,GO:0003723,GO:0003725,GO:0004004,GO:0005524,GO:0005739,GO:0005829,GO:0006396,GO:0035770,GO:0042645,GO:1902775 chromatin binding|RNA binding|double-stranded RNA binding|ATP-dependent RNA helicase activity|ATP binding|mitochondrion|cytosol|RNA processing|ribonucleoprotein granule|mitochondrial nucleoid|mitochondrial large ribosomal subunit assembly DHX32 968.411332042765 958.331033494898 978.491630590633 1.02103719528127 0.0300354229937841 0.843260828991573 1 11.0355 11.1358 12.1009 10.4747 GeneID:55760,Genbank:NM_018180.2,HGNC:HGNC:16717,MIM:607960 DEAH-box helicase 32 (putative) GO:0000398,GO:0003723,GO:0004004,GO:0005524,GO:0005681,GO:0005737,GO:0005739 mRNA splicing, via spliceosome|RNA binding|ATP-dependent RNA helicase activity|ATP binding|spliceosomal complex|cytoplasm|mitochondrion DHX33 1513.1634012939 1622.73998067924 1403.58682190857 0.864948690868555 -0.20931354089522 0.14985361726859 1 11.7949 11.4414 11.2486 9.11678 GeneID:56919,Genbank:NM_001199699.1,HGNC:HGNC:16718,MIM:614405 DEAH-box helicase 33 GO:0000182,GO:0003723,GO:0004004,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0006396,GO:0033613,GO:0045943 rDNA binding|RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleoplasm|nucleolus|cytoplasm|RNA processing|activating transcription factor binding|positive regulation of transcription from RNA polymerase I promoter hsa04621 NOD-like receptor signaling pathway DHX34 726.26945454362 713.463096653907 739.075812433333 1.0358991458697 0.0508835504797166 0.746685139164219 1 4.60742 4.19913 4.93021 4.55596 GeneID:9704,Genbank:NM_014681.5,HGNC:HGNC:16719,MIM:615475 DExH-box helicase 34 GO:0000956,GO:0003723,GO:0004004,GO:0005524,GO:0005737,GO:0006396,GO:0016020,GO:2000623 nuclear-transcribed mRNA catabolic process|RNA binding|ATP-dependent RNA helicase activity|ATP binding|cytoplasm|RNA processing|membrane|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay DHX35 319.445691167735 335.990774638882 302.900607696588 0.901514656234658 -0.14957714864829 0.442320385871477 1 3.19717 3.3215 3.08069 2.98845 GeneID:60625,Genbank:NM_021931.3,HGNC:HGNC:15861 DEAH-box helicase 35 GO:0000398,GO:0003723,GO:0004004,GO:0005524,GO:0005737,GO:0006396,GO:0071013 mRNA splicing, via spliceosome|RNA binding|ATP-dependent RNA helicase activity|ATP binding|cytoplasm|RNA processing|catalytic step 2 spliceosome DHX36 304.530292374117 304.683022842549 304.377561905685 0.99899744680877 -0.00144710403786925 0.974707951889956 1 3.14317 2.10182 3.26601 2.40658 GeneID:170506,Genbank:NM_001114397.1,HGNC:HGNC:14410,MIM:612767 DEAH-box helicase 36 GO:0000781,GO:0001047,GO:0001503,GO:0002151,GO:0003697,GO:0003723,GO:0003725,GO:0004004,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006351,GO:0006396,GO:0008094,GO:0009615,GO:0010501,GO:0032206,GO:0032481,GO:0042826,GO:0043330,GO:0044212,GO:0045944,GO:0051880,GO:0070034,GO:0070062,GO:0090669,GO:1902741 chromosome, telomeric region|core promoter binding|ossification|G-quadruplex RNA binding|single-stranded DNA binding|RNA binding|double-stranded RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|cytoplasm|cytosol|transcription, DNA-templated|RNA processing|DNA-dependent ATPase activity|response to virus|RNA secondary structure unwinding|positive regulation of telomere maintenance|positive regulation of type I interferon production|histone deacetylase binding|response to exogenous dsRNA|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|G-quadruplex DNA binding|telomerase RNA binding|extracellular exosome|telomerase RNA stabilization|positive regulation of interferon-alpha secretion hsa03018 RNA degradation DHX37 1344.50410786445 1282.57971179702 1406.42850393188 1.09656225729731 0.132987723315044 0.366606139168818 1 8.47922 8.3277 10.2577 8.80209 GeneID:57647,Genbank:NM_032656.3,HGNC:HGNC:17210,MIM:617362 DEAH-box helicase 37 GO:0003723,GO:0004004,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0006396 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleoplasm|nucleolus|cytoplasm|rRNA processing|RNA processing DHX38 1790.38258000087 1762.00548572854 1818.7596742732 1.03220999537422 0.0457365060959656 0.758171100956717 1 13.0315 13.4417 13.7762 14.0671 GeneID:9785,Genbank:XM_011523485.1,HGNC:HGNC:17211,MIM:605584 DEAH-box helicase 38 GO:0000398,GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006369,GO:0006405,GO:0006406,GO:0016020,GO:0031124,GO:0071013 mRNA splicing, via spliceosome|RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|membrane|mRNA 3'-end processing|catalytic step 2 spliceosome hsa03040 Spliceosome DHX40 1167.78811805422 1238.36640741552 1097.20982869291 0.886013882581642 -0.17459879094366 0.258136892600648 1 12.1752 11.0126 10.4497 9.96122 GeneID:79665,Genbank:NM_024612.4,HGNC:HGNC:18018,MIM:607570 DEAH-box helicase 40 GO:0000398,GO:0003723,GO:0004004,GO:0005524,GO:0005681,GO:0005737 mRNA splicing, via spliceosome|RNA binding|ATP-dependent RNA helicase activity|ATP binding|spliceosomal complex|cytoplasm DHX57 323.643338513828 346.310683044456 300.975993983201 0.869092432659852 -0.202418471301802 0.302674049453313 1 1.86447 1.78504 1.92219 1.47619 GeneID:90957,Genbank:NM_001329963.1,HGNC:HGNC:20086 DExH-box helicase 57 GO:0003723,GO:0004004,GO:0005524,GO:0005739,GO:0006396,GO:0046872 RNA binding|ATP-dependent RNA helicase activity|ATP binding|mitochondrion|RNA processing|metal ion binding DHX58 155.263952813995 86.0300186795774 224.497886948413 2.60952967806 1.38378980975552 0.267838148061111 1 1.15276 1.08427 4.54172 1.12219 GeneID:79132,Genbank:NM_024119.2,HGNC:HGNC:29517,MIM:608588 DExH-box helicase 58 GO:0003677,GO:0003725,GO:0003727,GO:0004386,GO:0005524,GO:0005737,GO:0008270,GO:0009615,GO:0016032,GO:0032480,GO:0032481,GO:0039534,GO:0039536,GO:0045087,GO:0045088,GO:0045824,GO:0051607,GO:1900245,GO:1900246 DNA binding|double-stranded RNA binding|single-stranded RNA binding|helicase activity|ATP binding|cytoplasm|zinc ion binding|response to virus|viral process|negative regulation of type I interferon production|positive regulation of type I interferon production|negative regulation of MDA-5 signaling pathway|negative regulation of RIG-I signaling pathway|innate immune response|regulation of innate immune response|negative regulation of innate immune response|defense response to virus|positive regulation of MDA-5 signaling pathway|positive regulation of RIG-I signaling pathway hsa04622 RIG-I-like receptor signaling pathway DHX8 2245.70312152457 2205.37566432245 2286.03057872668 1.03657196173379 0.0518202758614004 0.703111318165456 1 11.1221 10.5682 11.8027 10.6638 GeneID:1659,Genbank:NM_001322219.1,HGNC:HGNC:2749,MIM:600396 DEAH-box helicase 8 GO:0000398,GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006396,GO:0008380,GO:0016604,GO:0042802,GO:0071013 mRNA splicing, via spliceosome|RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|RNA processing|RNA splicing|nuclear body|identical protein binding|catalytic step 2 spliceosome hsa03040 Spliceosome DHX9 5874.20330249719 6373.16928145781 5375.23732353657 0.843416687389015 -0.245682528599684 0.0658168786014309 0.9056040615812 49.227 47.6005 43.9622 38.3088 GeneID:1660,Genbank:NM_001357.4,HGNC:HGNC:2750,MIM:603115 DExH-box helicase 9 DIABLO 1208.13561765083 1248.37280021108 1167.89843509057 0.935536592028515 -0.0961340115916496 0.500062631304624 1 15.3798 16.899 15.0626 15.6039 GeneID:56616,Genbank:NM_019887.5,HGNC:HGNC:21528,MIM:605219 diablo IAP-binding mitochondrial protein GO:0005739,GO:0005758,GO:0005829,GO:0006915,GO:0006919,GO:0008625,GO:0008631,GO:0008635,GO:0009898,GO:0035631,GO:0043065,GO:0051402,GO:0097193 mitochondrion|mitochondrial intermembrane space|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to oxidative stress|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|cytoplasmic side of plasma membrane|CD40 receptor complex|positive regulation of apoptotic process|neuron apoptotic process|intrinsic apoptotic signaling pathway hsa04210,hsa04215 Apoptosis|Apoptosis - multiple species DIAPH1 5055.61572423276 4953.67669642364 5157.55475204188 1.04115691598635 0.0581875180658834 0.669409226715212 1 20.3061 22.0233 23.501 20.8445 GeneID:1729,Genbank:XM_024454384.1,HGNC:HGNC:2876,MIM:602121 diaphanous related formin 1 hsa04510,hsa04810,hsa04933,hsa05131 Focal adhesion|Regulation of actin cytoskeleton|AGE-RAGE signaling pathway in diabetic complications|Shigellosis DIAPH2 114.635989087041 117.307327509732 111.96465066435 0.954455727883336 -0.0672498146436497 0.837737252522408 1 0.683719 0.622414 0.811674 0.554675 GeneID:1730,Genbank:NM_006729.4,HGNC:HGNC:2877,MIM:300108 diaphanous related formin 2 GO:0000910,GO:0003779,GO:0005102,GO:0005730,GO:0005769,GO:0005783,GO:0005829,GO:0007015,GO:0007275,GO:0007292,GO:0017048,GO:0043231,GO:0048477 cytokinesis|actin binding|receptor binding|nucleolus|early endosome|endoplasmic reticulum|cytosol|actin filament organization|multicellular organism development|female gamete generation|Rho GTPase binding|intracellular membrane-bounded organelle|oogenesis hsa04810 Regulation of actin cytoskeleton DIAPH3 619.299118109822 657.46068666182 581.137549557823 0.883912241975229 -0.178024954175613 0.436208983287406 1 1.52044 1.41032 1.55651 1.03856 GeneID:81624,Genbank:NM_001258368.1,HGNC:HGNC:15480,MIM:614567 diaphanous related formin 3 GO:0003779,GO:0005634,GO:0005829,GO:0007283,GO:0017048,GO:0030036,GO:0045296 actin binding|nucleus|cytosol|spermatogenesis|Rho GTPase binding|actin cytoskeleton organization|cadherin binding hsa04810 Regulation of actin cytoskeleton DICER1 298.16363766931 276.365759734355 319.961515604265 1.1577465888387 0.211319506320175 0.712051773493718 1 0.688902 0.577825 1.01296 0.462759 GeneID:23405,Genbank:XM_017021121.2,HGNC:HGNC:17098,MIM:606241 dicer 1, ribonuclease III hsa05206 MicroRNAs in cancer DIDO1 2459.97007796634 2527.81794449591 2392.12221143678 0.946319024534739 -0.0796014657365264 0.568277102922488 1 6.8873 6.68117 6.65372 6.4404 GeneID:11083,Genbank:NM_033081.2,HGNC:HGNC:2680,MIM:604140 death inducer-obliterator 1 GO:0003723,GO:0005634,GO:0005737,GO:0005819,GO:0006351,GO:0046872,GO:0097190 RNA binding|nucleus|cytoplasm|spindle|transcription, DNA-templated|metal ion binding|apoptotic signaling pathway DIEXF 667.328433379043 750.150808215808 584.506058542278 0.779184734776855 -0.359962681426883 0.0281450453283465 0.668561867500627 3.06246 3.01746 2.66606 2.15799 GeneID:27042,Genbank:NM_014388.6,HGNC:HGNC:28440 digestive organ expansion factor homolog (zebrafish) GO:0000462,GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0007275,GO:0019843,GO:0032040,GO:0034511 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|nucleolus|rRNA processing|multicellular organism development|rRNA binding|small-subunit processome|U3 snoRNA binding DIMT1 799.233825606826 903.531314371645 694.936336842007 0.769133649037163 -0.378693784021631 0.0161998165666372 0.529251203244782 10.2045 10.5429 8.72275 8.31071 GeneID:27292,Genbank:NM_014473.3,HGNC:HGNC:30217,MIM:612499 DIM1 dimethyladenosine transferase 1 homolog GO:0000179,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005759,GO:0005829,GO:0031167,GO:0052909,GO:2000234 rRNA (adenine-N6,N6-)-dimethyltransferase activity|RNA binding|nucleus|nucleoplasm|nucleolus|mitochondrial matrix|cytosol|rRNA methylation|18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity|positive regulation of rRNA processing DIO1 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.0605249 0 0 GeneID:1733,Genbank:NM_000792.6,HGNC:HGNC:2883,MIM:147892 iodothyronine deiodinase 1 hsa04919 Thyroid hormone signaling pathway DIO2 202.506969210637 213.541584735297 191.472353685976 0.896651366165153 -0.157380945945938 0.73819478315322 1 1.25485 0.943209 1.24789 0.732327 GeneID:1734,Genbank:NM_000793.5,HGNC:HGNC:2884,MIM:601413 iodothyronine deiodinase 2 hsa04919 Thyroid hormone signaling pathway DIP2A 950.122525336182 947.944498505278 952.300552167086 1.00459526234782 0.00661437641601249 0.982099432698331 1 2.96307 3.22165 3.1757 3.07904 GeneID:23181,Genbank:XM_017028300.1,HGNC:HGNC:17217,MIM:607711 disco interacting protein 2 homolog A GO:0003824,GO:0005634,GO:0007275,GO:0008152,GO:0009986,GO:0010629,GO:0042981 catalytic activity|nucleus|multicellular organism development|metabolic process|cell surface|negative regulation of gene expression|regulation of apoptotic process DIP2B 1528.37381666983 1481.48578105764 1575.26185228203 1.0632986643702 0.0885468848145221 0.688417736015009 1 7.28241 6.68584 8.85573 6.22459 GeneID:57609,Genbank:NM_173602.2,HGNC:HGNC:29284,MIM:611379 disco interacting protein 2 homolog B GO:0003824,GO:0005634,GO:0005737,GO:0008152,GO:0016020,GO:0070062 catalytic activity|nucleus|cytoplasm|metabolic process|membrane|extracellular exosome DIP2C 1252.65106404987 1056.72749008214 1448.5746380176 1.37081191850606 0.455030640517174 0.0020190112373913 0.159293024522459 3.57127 3.2937 4.98176 4.55134 GeneID:22982,Genbank:NM_014974.2,HGNC:HGNC:29150,MIM:611380 disco interacting protein 2 homolog C GO:0003824,GO:0008152 catalytic activity|metabolic process DIRAS1 144.561250642852 139.870229309986 149.252271975717 1.06707676617115 0.0936639682809997 0.859941318518257 1 1.23009 2.01796 1.66218 1.91416 GeneID:148252,Genbank:NM_145173.3,HGNC:HGNC:19127,MIM:607862 DIRAS family GTPase 1 GO:0003924,GO:0005525,GO:0005886,GO:0007165 GTPase activity|GTP binding|plasma membrane|signal transduction DIRAS2 13.3360452467098 11.6558524424989 15.0162380509207 1.28830028734487 0.365468907559531 0.762797128751383 1 0.0870238 0.130634 0.0723496 0.231165 GeneID:54769,Genbank:NM_017594.4,HGNC:HGNC:19323,MIM:607863 DIRAS family GTPase 2 GO:0003924,GO:0005525,GO:0005886,GO:0007165 GTPase activity|GTP binding|plasma membrane|signal transduction DIRAS3 169.003974240688 186.310325635495 151.697622845881 0.814220158375272 -0.296509154878335 0.217206977126186 1 4.44878 4.78729 4.1553 3.42668 GeneID:9077,Genbank:NM_004675.3,HGNC:HGNC:687,MIM:605193 DIRAS family GTPase 3 DIRC2 293.556222525228 260.444360499149 326.668084551306 1.2542720599718 0.326850312255724 0.108823961348064 1 3.66007 4.23996 5.7743 4.48399 GeneID:84925,Genbank:NM_032839.2,HGNC:HGNC:16628,MIM:602773 disrupted in renal carcinoma 2 DIS3 304.52427338384 321.133728100144 287.914818667537 0.896557394861221 -0.157532151915081 0.717072961161074 1 1.66123 1.13613 1.49958 0.985061 GeneID:22894,Genbank:NM_001322348.1,HGNC:HGNC:20604,MIM:607533 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease GO:0000175,GO:0000176,GO:0000178,GO:0003723,GO:0004519,GO:0005085,GO:0005634,GO:0005654,GO:0005829,GO:0006364,GO:0016020,GO:0016075,GO:0043488,GO:0043928,GO:0071034 3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|exosome (RNase complex)|RNA binding|endonuclease activity|guanyl-nucleotide exchange factor activity|nucleus|nucleoplasm|cytosol|rRNA processing|membrane|rRNA catabolic process|regulation of mRNA stability|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|CUT catabolic process hsa03018 RNA degradation DIS3L 653.548529560524 687.730460724446 619.366598396603 0.900594976910243 -0.151049663850834 0.358850188500071 1 3.39928 3.51074 3.29632 3.0706 GeneID:115752,Genbank:NM_133375.4,HGNC:HGNC:28698,MIM:614183 DIS3 like exosome 3'-5' exoribonuclease GO:0000175,GO:0000177,GO:0003723,GO:0005813,GO:0005829,GO:0005886,GO:0006364,GO:0016075,GO:0019899 3'-5'-exoribonuclease activity|cytoplasmic exosome (RNase complex)|RNA binding|centrosome|cytosol|plasma membrane|rRNA processing|rRNA catabolic process|enzyme binding hsa03018 RNA degradation DIS3L2 374.920022388624 361.666592639405 388.173452137843 1.0732908707575 0.102041111445388 0.61374675776187 1 2.58942 3.14363 3.07021 3.13631 GeneID:129563,Genbank:NM_001257281.1,HGNC:HGNC:28648,MIM:614184 DIS3 like 3'-5' exoribonuclease 2 GO:0000175,GO:0000178,GO:0000278,GO:0000287,GO:0000291,GO:0000932,GO:0004540,GO:0005737,GO:0005844,GO:0006364,GO:0008266,GO:0008285,GO:0010587,GO:0019827,GO:0034427,GO:0051301,GO:0051306,GO:1990074 3'-5'-exoribonuclease activity|exosome (RNase complex)|mitotic cell cycle|magnesium ion binding|nuclear-transcribed mRNA catabolic process, exonucleolytic|P-body|ribonuclease activity|cytoplasm|polysome|rRNA processing|poly(U) RNA binding|negative regulation of cell proliferation|miRNA catabolic process|stem cell population maintenance|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|cell division|mitotic sister chromatid separation|polyuridylation-dependent mRNA catabolic process DISC1 55.6133126514993 61.7861972653499 49.4404280376487 0.800185643814904 -0.321593349461579 0.420574010932779 1 0.19105 0.143152 0.176783 0.0959073 GeneID:27185,Genbank:NM_001164537.1,HGNC:HGNC:2888,MIM:605210 DISC1 scaffold protein GO:0000226,GO:0001764,GO:0002052,GO:0005739,GO:0005813,GO:0005874,GO:0014069,GO:0016055,GO:0030054,GO:0030177,GO:0032091,GO:0045111,GO:0045211,GO:0097546,GO:1905515 microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|mitochondrion|centrosome|microtubule|postsynaptic density|Wnt signaling pathway|cell junction|positive regulation of Wnt signaling pathway|negative regulation of protein binding|intermediate filament cytoskeleton|postsynaptic membrane|ciliary base|non-motile cilium assembly DISP1 418.840389846661 404.896703214421 432.784076478902 1.06887527866512 0.0960935225170218 0.585684147589504 1 1.92827 1.71622 2.12727 1.85728 GeneID:84976,Genbank:XM_011510075.2,HGNC:HGNC:19711,MIM:607502 dispatched RND transporter family member 1 GO:0007224,GO:0007225,GO:0007368,GO:0009880,GO:0009953,GO:0015197,GO:0015833,GO:0016021,GO:0016323,GO:0050708,GO:0060539,GO:0070207 smoothened signaling pathway|patched ligand maturation|determination of left/right symmetry|embryonic pattern specification|dorsal/ventral pattern formation|peptide transporter activity|peptide transport|integral component of membrane|basolateral plasma membrane|regulation of protein secretion|diaphragm development|protein homotrimerization DISP2 44.7090998212036 43.8652778018831 45.5529218405241 1.03847334664705 0.0544641885912453 0.90952888325484 1 0.258186 0.188324 0.22978 0.234829 GeneID:85455,Genbank:XM_011522125.3,HGNC:HGNC:19712,MIM:607503 dispatched RND transporter family member 2 GO:0005886,GO:0007224,GO:0016021 plasma membrane|smoothened signaling pathway|integral component of membrane DISP3 1.4618395847634 1.47021420587209 1.45346496365472 0.988607617753608 -0.0165300716253246 1 1 0 0.0119132 0 0.00599242 GeneID:57540,Genbank:XM_011541830.2,HGNC:HGNC:29251,MIM:611251 dispatched RND transporter family member 3 GO:0005737,GO:0005783,GO:0005789,GO:0007224,GO:0008203,GO:0016021,GO:0030659,GO:0031965,GO:0032368,GO:0042632,GO:0045665,GO:0045834,GO:2000179 cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|smoothened signaling pathway|cholesterol metabolic process|integral component of membrane|cytoplasmic vesicle membrane|nuclear membrane|regulation of lipid transport|cholesterol homeostasis|negative regulation of neuron differentiation|positive regulation of lipid metabolic process|positive regulation of neural precursor cell proliferation DIXDC1 340.774266906599 387.859874005499 293.688659807699 0.757202999048917 -0.401247969761708 0.039252621574843 0.75470586691799 1.89725 1.74821 1.45277 1.38209 GeneID:85458,Genbank:NM_001278542.1,HGNC:HGNC:23695,MIM:610493 DIX domain containing 1 GO:0003779,GO:0005829,GO:0005925,GO:0007049,GO:0019904,GO:0021799,GO:0021869,GO:0032956,GO:0043015,GO:0045665,GO:0060070,GO:0070507,GO:0090263 actin binding|cytosol|focal adhesion|cell cycle|protein domain specific binding|cerebral cortex radially oriented cell migration|forebrain ventricular zone progenitor cell division|regulation of actin cytoskeleton organization|gamma-tubulin binding|negative regulation of neuron differentiation|canonical Wnt signaling pathway|regulation of microtubule cytoskeleton organization|positive regulation of canonical Wnt signaling pathway DKC1 3247.94928768253 3467.45760413067 3028.44097123438 0.87338947349398 -0.195302951712348 0.155497408698549 1 37.3579 35.2727 32.9272 31.5675 GeneID:1736,Genbank:NM_001288747.1,HGNC:HGNC:2890,MIM:300126 dyskerin pseudouridine synthase 1 hsa03008 Ribosome biogenesis in eukaryotes DKK1 11540.750456429 11895.3686944198 11186.1322184381 0.94037709177401 -0.088688700501472 0.495332576977527 1 318.15 322.77 309.548 298.477 GeneID:22943,Genbank:NM_012242.3,HGNC:HGNC:2891,MIM:605189 dickkopf WNT signaling pathway inhibitor 1 hsa04310 Wnt signaling pathway DKK2 6.36621812998825 8.36943145285216 4.36300480712434 0.521302412440155 -0.939807558553294 0.469245601986068 1 0.136685 0.0591947 0.0715036 0.0331768 GeneID:27123,Genbank:NM_014421.2,HGNC:HGNC:2892,MIM:605415 dickkopf WNT signaling pathway inhibitor 2 GO:0005615,GO:0007275,GO:0016055,GO:0039706,GO:0090090,GO:0090263 extracellular space|multicellular organism development|Wnt signaling pathway|co-receptor binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway hsa04310 Wnt signaling pathway DKK3 6424.09612542718 6367.45146512117 6480.74078573319 1.01779194097239 0.0254426729995776 0.862574297030827 1 60.3597 63.6084 63.5748 64.3032 GeneID:27122,Genbank:NM_013253.4,HGNC:HGNC:2893,MIM:605416 dickkopf WNT signaling pathway inhibitor 3 GO:0005615,GO:0009653,GO:0016055,GO:0017015,GO:0030325,GO:0032348,GO:0045892,GO:0090090,GO:1902613,GO:2000065 extracellular space|anatomical structure morphogenesis|Wnt signaling pathway|regulation of transforming growth factor beta receptor signaling pathway|adrenal gland development|negative regulation of aldosterone biosynthetic process|negative regulation of transcription, DNA-templated|negative regulation of canonical Wnt signaling pathway|negative regulation of anti-Mullerian hormone signaling pathway|negative regulation of cortisol biosynthetic process DKKL1 2.91530454841812 1.47021420587209 4.36039489096415 2.96582285326082 1.56843242909583 0.47413413945601 1 0 0 0.021206 0.0797823 GeneID:27120,Genbank:XM_011526725.1,HGNC:HGNC:16528,MIM:605418 dickkopf like acrosomal protein 1 GO:0001669,GO:0004871,GO:0005615,GO:0007341,GO:0009653,GO:0043065,GO:0045600,GO:2000225 acrosomal vesicle|signal transducer activity|extracellular space|penetration of zona pellucida|anatomical structure morphogenesis|positive regulation of apoptotic process|positive regulation of fat cell differentiation|negative regulation of testosterone biosynthetic process DLAT 752.618169030658 806.36290661514 698.873431446176 0.866698388173419 -0.206398073287073 0.208092805769426 1 7.99461 7.30781 7.27749 6.03309 GeneID:1737,Genbank:NM_001931.4,HGNC:HGNC:2896,MIM:608770 dihydrolipoamide S-acetyltransferase GO:0004742,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0006086,GO:0006090,GO:0006099,GO:0010510,GO:0030431,GO:0034641,GO:0042802,GO:0043209,GO:0045254 dihydrolipoyllysine-residue acetyltransferase activity|mitochondrion|mitochondrial matrix|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|acetyl-CoA biosynthetic process from pyruvate|pyruvate metabolic process|tricarboxylic acid cycle|regulation of acetyl-CoA biosynthetic process from pyruvate|sleep|cellular nitrogen compound metabolic process|identical protein binding|myelin sheath|pyruvate dehydrogenase complex hsa00010,hsa00020,hsa00620 Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism DLC1 160.823266770179 170.926007076077 150.72052646428 0.881788143551472 -0.181496016158346 0.469938666973084 1 0.618558 0.651623 0.608217 0.555475 GeneID:10395,Genbank:XM_005273374.1,HGNC:HGNC:2897,MIM:604258 DLC1 Rho GTPase activating protein DLD 1537.26173850323 1593.94042082248 1480.58305618398 0.928882307545714 -0.106432280923616 0.47859676583841 1 20.3539 19.0842 19.6295 17.3667 GeneID:1738,Genbank:NM_000108.4,HGNC:HGNC:2898,MIM:238331 dihydrolipoamide dehydrogenase GO:0004148,GO:0005654,GO:0005739,GO:0005759,GO:0006090,GO:0006099,GO:0006103,GO:0006120,GO:0006508,GO:0006554,GO:0007369,GO:0007568,GO:0009055,GO:0009083,GO:0009106,GO:0010510,GO:0031514,GO:0034641,GO:0042391,GO:0043159,GO:0043209,GO:0043544,GO:0045252,GO:0045254,GO:0045454,GO:0048240,GO:0050660,GO:0051068,GO:0051287,GO:0061732 dihydrolipoyl dehydrogenase activity|nucleoplasm|mitochondrion|mitochondrial matrix|pyruvate metabolic process|tricarboxylic acid cycle|2-oxoglutarate metabolic process|mitochondrial electron transport, NADH to ubiquinone|proteolysis|lysine catabolic process|gastrulation|aging|electron transfer activity|branched-chain amino acid catabolic process|lipoate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|motile cilium|cellular nitrogen compound metabolic process|regulation of membrane potential|acrosomal matrix|myelin sheath|lipoamide binding|oxoglutarate dehydrogenase complex|pyruvate dehydrogenase complex|cell redox homeostasis|sperm capacitation|flavin adenine dinucleotide binding|dihydrolipoamide metabolic process|NAD binding|mitochondrial acetyl-CoA biosynthetic process from pyruvate hsa00010,hsa00020,hsa00260,hsa00280,hsa00620,hsa00630,hsa00640 Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Glycine, serine and threonine metabolism|Valine, leucine and isoleucine degradation|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism DLEC1 11.5329024700573 14.8266035725598 8.23920136755471 0.555703895854026 -0.847611740311428 0.574785502472797 1 0.00645692 0 0.0181338 0 GeneID:9940,Genbank:XM_006713438.3,HGNC:HGNC:2899,MIM:604050 deleted in lung and esophageal cancer 1 GO:0005737,GO:0005829,GO:0008285 cytoplasm|cytosol|negative regulation of cell proliferation DLEU7 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.0306178 0.0143949 0 0 GeneID:220107,Genbank:NM_198989.3,HGNC:HGNC:17567 deleted in lymphocytic leukemia, 7 DLG1 2476.9519891976 2690.50370528381 2263.40027311139 0.841255215023996 -0.24938455172793 0.248887998303247 1 9.8244 8.04021 8.5628 6.7343 GeneID:1739,Genbank:NM_001290983.1,HGNC:HGNC:2900,MIM:601014 discs large MAGUK scaffold protein 1 hsa04390,hsa04530,hsa04660,hsa05165,hsa05166,hsa05203 Hippo signaling pathway|Tight junction|T cell receptor signaling pathway|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Viral carcinogenesis DLG2 14.1249193082993 9.34957425676688 18.9002643598317 2.02151069565038 1.01543383681314 0.182955745491366 1 0.00985924 0.0112818 0.0208449 0.0264608 GeneID:1740,Genbank:XM_017017256.2,HGNC:HGNC:2901,MIM:603583 discs large MAGUK scaffold protein 2 GO:0004385,GO:0005829,GO:0005886,GO:0007268,GO:0007399,GO:0010923,GO:0014069,GO:0016020,GO:0019233,GO:0019900,GO:0030054,GO:0035255,GO:0043113,GO:0044224,GO:0045211,GO:0097120 guanylate kinase activity|cytosol|plasma membrane|chemical synaptic transmission|nervous system development|negative regulation of phosphatase activity|postsynaptic density|membrane|sensory perception of pain|kinase binding|cell junction|ionotropic glutamate receptor binding|receptor clustering|juxtaparanode region of axon|postsynaptic membrane|receptor localization to synapse hsa04390,hsa04530,hsa05165 Hippo signaling pathway|Tight junction|Human papillomavirus infection DLG3 482.660178658182 416.678034171613 548.64232314475 1.31670565316814 0.396932870137926 0.0245745319870006 0.624739213180639 1.62747 1.67497 2.51948 1.94357 GeneID:1741,Genbank:XM_006724625.2,HGNC:HGNC:2902,MIM:300189 discs large MAGUK scaffold protein 3 GO:0001736,GO:0004385,GO:0005615,GO:0005737,GO:0005886,GO:0005911,GO:0005923,GO:0007268,GO:0007399,GO:0008022,GO:0010923,GO:0014069,GO:0016323,GO:0019900,GO:0019902,GO:0019903,GO:0019904,GO:0030165,GO:0030426,GO:0031625,GO:0032281,GO:0035255,GO:0043025,GO:0043113,GO:0043198,GO:0045197,GO:0045202,GO:0045211,GO:0061098,GO:0097120 establishment of planar polarity|guanylate kinase activity|extracellular space|cytoplasm|plasma membrane|cell-cell junction|bicellular tight junction|chemical synaptic transmission|nervous system development|protein C-terminus binding|negative regulation of phosphatase activity|postsynaptic density|basolateral plasma membrane|kinase binding|phosphatase binding|protein phosphatase binding|protein domain specific binding|PDZ domain binding|growth cone|ubiquitin protein ligase binding|AMPA glutamate receptor complex|ionotropic glutamate receptor binding|neuronal cell body|receptor clustering|dendritic shaft|establishment or maintenance of epithelial cell apical/basal polarity|synapse|postsynaptic membrane|positive regulation of protein tyrosine kinase activity|receptor localization to synapse hsa04390,hsa04530,hsa05165 Hippo signaling pathway|Tight junction|Human papillomavirus infection DLG4 717.381810810787 711.695933145672 723.067688475903 1.01597839020938 0.022869716411932 0.905356005085652 1 2.92193 3.09117 3.27692 3.2172 GeneID:1742,Genbank:NM_001321074.1,HGNC:HGNC:2903,MIM:602887 discs large MAGUK scaffold protein 4 GO:0000165,GO:0002091,GO:0004385,GO:0005088,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0006461,GO:0007165,GO:0007204,GO:0007268,GO:0007399,GO:0007612,GO:0008021,GO:0008022,GO:0014069,GO:0015276,GO:0016188,GO:0016323,GO:0019900,GO:0019903,GO:0030054,GO:0030165,GO:0030666,GO:0030863,GO:0031234,GO:0031697,GO:0031748,GO:0031812,GO:0032281,GO:0032403,GO:0032839,GO:0033130,GO:0035176,GO:0035255,GO:0035418,GO:0035641,GO:0043197,GO:0044224,GO:0044300,GO:0044306,GO:0044309,GO:0045184,GO:0045197,GO:0045202,GO:0045211,GO:0048169,GO:0050806,GO:0050885,GO:0060076,GO:0060997,GO:0061098,GO:0071625,GO:0097109,GO:0097110,GO:0097113,GO:0097120,GO:0098839,GO:2000310,GO:2000463,GO:2000821 MAPK cascade|negative regulation of receptor internalization|guanylate kinase activity|Ras guanyl-nucleotide exchange factor activity|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|protein complex assembly|signal transduction|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|nervous system development|learning|synaptic vesicle|protein C-terminus binding|postsynaptic density|ligand-gated ion channel activity|synaptic vesicle maturation|basolateral plasma membrane|kinase binding|protein phosphatase binding|cell junction|PDZ domain binding|endocytic vesicle membrane|cortical cytoskeleton|extrinsic component of cytoplasmic side of plasma membrane|beta-1 adrenergic receptor binding|D1 dopamine receptor binding|P2Y1 nucleotide receptor binding|AMPA glutamate receptor complex|protein complex binding|dendrite cytoplasm|acetylcholine receptor binding|social behavior|ionotropic glutamate receptor binding|protein localization to synapse|locomotory exploration behavior|dendritic spine|juxtaparanode region of axon|cerebellar mossy fiber|neuron projection terminus|neuron spine|establishment of protein localization|establishment or maintenance of epithelial cell apical/basal polarity|synapse|postsynaptic membrane|regulation of long-term neuronal synaptic plasticity|positive regulation of synaptic transmission|neuromuscular process controlling balance|excitatory synapse|dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|vocalization behavior|neuroligin family protein binding|scaffold protein binding|AMPA glutamate receptor clustering|receptor localization to synapse|postsynaptic density membrane|regulation of NMDA receptor activity|positive regulation of excitatory postsynaptic potential|regulation of grooming behavior hsa04390,hsa04724,hsa05016,hsa05030 Hippo signaling pathway|Glutamatergic synapse|Huntington disease|Cocaine addiction DLG5 4423.53695672513 3802.43306934863 5044.64084410163 1.32668761082646 0.407828705774115 0.00234537410739028 0.176586018318416 11.496 11.5748 16.6298 14.8941 GeneID:9231,Genbank:XM_005270276.4,HGNC:HGNC:2904,MIM:604090 discs large MAGUK scaffold protein 5 GO:0001837,GO:0005737,GO:0005886,GO:0005913,GO:0006461,GO:0007165,GO:0008013,GO:0008092,GO:0008285,GO:0014069,GO:0030011,GO:0030054,GO:0030159,GO:0030336,GO:0030859,GO:0030901,GO:0035331,GO:0035332,GO:0035556,GO:0036064,GO:0042130,GO:0042981,GO:0045176,GO:0045186,GO:0045197,GO:0045211,GO:0045880,GO:0051965,GO:0060441,GO:0060999,GO:0071896,GO:0072205,GO:0098609 epithelial to mesenchymal transition|cytoplasm|plasma membrane|cell-cell adherens junction|protein complex assembly|signal transduction|beta-catenin binding|cytoskeletal protein binding|negative regulation of cell proliferation|postsynaptic density|maintenance of cell polarity|cell junction|receptor signaling complex scaffold activity|negative regulation of cell migration|polarized epithelial cell differentiation|midbrain development|negative regulation of hippo signaling|positive regulation of hippo signaling|intracellular signal transduction|ciliary basal body|negative regulation of T cell proliferation|regulation of apoptotic process|apical protein localization|zonula adherens assembly|establishment or maintenance of epithelial cell apical/basal polarity|postsynaptic membrane|positive regulation of smoothened signaling pathway|positive regulation of synapse assembly|epithelial tube branching involved in lung morphogenesis|positive regulation of dendritic spine development|protein localization to adherens junction|metanephric collecting duct development|cell-cell adhesion DLGAP1 1.23875045746879 0.538097676642304 1.93940323829528 3.60418437484629 1.84967281522267 0.680545261345893 1 0 0 0.011769 0.00365646 GeneID:9229,Genbank:XM_024451288.1,HGNC:HGNC:2905,MIM:605445 DLG associated protein 1 GO:0005886,GO:0006461,GO:0007268,GO:0014069,GO:0019904,GO:0030054,GO:0045202,GO:0045211 plasma membrane|protein complex assembly|chemical synaptic transmission|postsynaptic density|protein domain specific binding|cell junction|synapse|postsynaptic membrane hsa04724 Glutamatergic synapse DLGAP3 3.45971028251071 3.52655236307142 3.39286820195 0.962092109415047 -0.0557530725812868 1 1 0.0084733 0.019068 0.00398826 0.0111719 GeneID:58512,Genbank:XM_011541879.2,HGNC:HGNC:30368,MIM:611413 DLG associated protein 3 GO:0001540,GO:0005886,GO:0006461,GO:0014069,GO:0019904,GO:0023052,GO:0030054,GO:0045202,GO:0045211 amyloid-beta binding|plasma membrane|protein complex assembly|postsynaptic density|protein domain specific binding|signaling|cell junction|synapse|postsynaptic membrane DLGAP4 1448.67251553953 1303.87329614439 1593.47173493467 1.22210627339837 0.289369746235456 0.0465537217785145 0.79332376136203 7.71101 7.49887 9.7863 8.74525 GeneID:22839,Genbank:NM_014902.5,HGNC:HGNC:24476,MIM:616191 DLG associated protein 4 GO:0005886,GO:0006461,GO:0019904,GO:0023052,GO:0045202 plasma membrane|protein complex assembly|protein domain specific binding|signaling|synapse DLGAP5 738.68846011803 750.379096932415 726.997823303644 0.96884071834576 -0.0456685951306805 0.905368536591813 1 6.24326 4.39267 5.96101 4.73566 GeneID:9787,Genbank:NM_014750.4,HGNC:HGNC:16864,MIM:617859 DLG associated protein 5 GO:0004721,GO:0005634,GO:0005739,GO:0005815,GO:0005829,GO:0006461,GO:0007079,GO:0007221,GO:0008283,GO:0031616,GO:0045842 phosphoprotein phosphatase activity|nucleus|mitochondrion|microtubule organizing center|cytosol|protein complex assembly|mitotic chromosome movement towards spindle pole|positive regulation of transcription of Notch receptor target|cell proliferation|spindle pole centrosome|positive regulation of mitotic metaphase/anaphase transition DLK1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00867473 GeneID:8788,Genbank:NM_003836.6,HGNC:HGNC:2907,MIM:176290 delta like non-canonical Notch ligand 1 GO:0005509,GO:0005615,GO:0016021,GO:0030154,GO:0045746 calcium ion binding|extracellular space|integral component of membrane|cell differentiation|negative regulation of Notch signaling pathway DLK2 42.4313137090003 37.8501508094479 47.0124766085526 1.24206840932369 0.31274463497072 0.493842795770039 1 0.543382 0.651249 0.974479 0.80482 GeneID:65989,Genbank:NM_001286655.1,HGNC:HGNC:21113 delta like non-canonical Notch ligand 2 GO:0005509,GO:0016021,GO:0042803,GO:0045598,GO:0045746,GO:0070062 calcium ion binding|integral component of membrane|protein homodimerization activity|regulation of fat cell differentiation|negative regulation of Notch signaling pathway|extracellular exosome DLL1 101.745997510714 96.8596157973243 106.632379224105 1.10089616138092 0.13867839758017 0.673980359531356 1 1.0863 1.26429 1.51999 1.17575 GeneID:28514,Genbank:XM_005266934.4,HGNC:HGNC:2908,MIM:606582 delta like canonical Notch ligand 1 GO:0001709,GO:0001756,GO:0001757,GO:0001947,GO:0002315,GO:0003323,GO:0005112,GO:0005509,GO:0005576,GO:0005886,GO:0005887,GO:0005912,GO:0007219,GO:0007220,GO:0007368,GO:0007386,GO:0008217,GO:0008284,GO:0008285,GO:0009954,GO:0014002,GO:0014807,GO:0016324,GO:0021510,GO:0021688,GO:0021693,GO:0030097,GO:0030154,GO:0030155,GO:0030857,GO:0030957,GO:0031410,GO:0032693,GO:0034351,GO:0035265,GO:0035333,GO:0040008,GO:0045121,GO:0045596,GO:0045605,GO:0045608,GO:0045638,GO:0045662,GO:0045665,GO:0045747,GO:0045807,GO:0045944,GO:0046331,GO:0048630,GO:0048631,GO:0048633,GO:0048665,GO:0048839,GO:0050767,GO:0051302,GO:0060041,GO:0060042,GO:0060853,GO:0070986,GO:0072006,GO:0072014,GO:0072070,GO:0072583,GO:0097102,GO:0097110,GO:0097150,GO:0098773,GO:1900746,GO:1903672,GO:2000505,GO:2000726 cell fate determination|somitogenesis|somite specification|heart looping|marginal zone B cell differentiation|type B pancreatic cell development|Notch binding|calcium ion binding|extracellular region|plasma membrane|integral component of plasma membrane|adherens junction|Notch signaling pathway|Notch receptor processing|determination of left/right symmetry|compartment pattern specification|regulation of blood pressure|positive regulation of cell proliferation|negative regulation of cell proliferation|proximal/distal pattern formation|astrocyte development|regulation of somitogenesis|apical plasma membrane|spinal cord development|cerebellar molecular layer formation|cerebellar Purkinje cell layer structural organization|hemopoiesis|cell differentiation|regulation of cell adhesion|negative regulation of epithelial cell differentiation|Tat protein binding|cytoplasmic vesicle|negative regulation of interleukin-10 production|negative regulation of glial cell apoptotic process|organ growth|Notch receptor processing, ligand-dependent|regulation of growth|membrane raft|negative regulation of cell differentiation|negative regulation of epidermal cell differentiation|negative regulation of inner ear auditory receptor cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of myoblast differentiation|negative regulation of neuron differentiation|positive regulation of Notch signaling pathway|positive regulation of endocytosis|positive regulation of transcription from RNA polymerase II promoter|lateral inhibition|skeletal muscle tissue growth|regulation of skeletal muscle tissue growth|positive regulation of skeletal muscle tissue growth|neuron fate specification|inner ear development|regulation of neurogenesis|regulation of cell division|retina development in camera-type eye|retina morphogenesis in camera-type eye|Notch signaling pathway involved in arterial endothelial cell fate commitment|left/right axis specification|nephron development|proximal tubule development|loop of Henle development|clathrin-dependent endocytosis|endothelial tip cell fate specification|scaffold protein binding|neuronal stem cell population maintenance|skin epidermis development|regulation of vascular endothelial growth factor signaling pathway|positive regulation of sprouting angiogenesis|regulation of energy homeostasis|negative regulation of cardiac muscle cell differentiation hsa01522,hsa04330,hsa04658,hsa05200,hsa05224 Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Pathways in cancer|Breast cancer DLL3 38.157328715392 46.7576799389423 29.5569774918417 0.632130968226783 -0.661704600351435 0.154545840413294 1 1.14054 0.890102 0.466468 0.838972 GeneID:10683,Genbank:NM_016941.3,HGNC:HGNC:2909,MIM:602768 delta like canonical Notch ligand 3 GO:0001501,GO:0001756,GO:0005112,GO:0005509,GO:0007219,GO:0007386,GO:0016021,GO:0048339,GO:0050768 skeletal system development|somitogenesis|Notch binding|calcium ion binding|Notch signaling pathway|compartment pattern specification|integral component of membrane|paraxial mesoderm development|negative regulation of neurogenesis hsa01522,hsa04330,hsa04658,hsa05200,hsa05224 Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Pathways in cancer|Breast cancer DLL4 2.20921368219474 1.02816907859967 3.39025828578981 3.29737429023564 1.7213176589277 0.509884641904143 1 0.0153551 0.0133605 0.0142567 0.079619 GeneID:54567,Genbank:NM_019074.3,HGNC:HGNC:2910,MIM:605185 delta like canonical Notch ligand 4 GO:0000122,GO:0001525,GO:0001569,GO:0001974,GO:0003208,GO:0003209,GO:0003222,GO:0003344,GO:0005112,GO:0005509,GO:0005886,GO:0007165,GO:0007219,GO:0007220,GO:0007601,GO:0008015,GO:0008285,GO:0010596,GO:0010628,GO:0010629,GO:0016021,GO:0030217,GO:0035333,GO:0035912,GO:0035924,GO:0044344,GO:0045746,GO:0045747,GO:0050767,GO:0060579,GO:0061074,GO:0061314,GO:0072554,GO:0090051,GO:1903588,GO:2000179 negative regulation of transcription from RNA polymerase II promoter|angiogenesis|branching involved in blood vessel morphogenesis|blood vessel remodeling|cardiac ventricle morphogenesis|cardiac atrium morphogenesis|ventricular trabecula myocardium morphogenesis|pericardium morphogenesis|Notch binding|calcium ion binding|plasma membrane|signal transduction|Notch signaling pathway|Notch receptor processing|visual perception|blood circulation|negative regulation of cell proliferation|negative regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|integral component of membrane|T cell differentiation|Notch receptor processing, ligand-dependent|dorsal aorta morphogenesis|cellular response to vascular endothelial growth factor stimulus|cellular response to fibroblast growth factor stimulus|negative regulation of Notch signaling pathway|positive regulation of Notch signaling pathway|regulation of neurogenesis|ventral spinal cord interneuron fate commitment|regulation of neural retina development|Notch signaling involved in heart development|blood vessel lumenization|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|positive regulation of neural precursor cell proliferation hsa01522,hsa04330,hsa04658,hsa05200,hsa05224 Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Pathways in cancer|Breast cancer DLST 2799.86418629485 2780.18306519202 2819.54530739767 1.01415814760491 0.0202826434407469 0.897878755607778 1 27.541 29.601 30.2319 28.98 GeneID:1743,Genbank:NM_001933.4,HGNC:HGNC:2911,MIM:126063 dihydrolipoamide S-succinyltransferase GO:0004149,GO:0005634,GO:0005759,GO:0006091,GO:0006099,GO:0006554,GO:0016020,GO:0033512,GO:0034641,GO:0043209,GO:0045252,GO:0070062 dihydrolipoyllysine-residue succinyltransferase activity|nucleus|mitochondrial matrix|generation of precursor metabolites and energy|tricarboxylic acid cycle|lysine catabolic process|membrane|L-lysine catabolic process to acetyl-CoA via saccharopine|cellular nitrogen compound metabolic process|myelin sheath|oxoglutarate dehydrogenase complex|extracellular exosome hsa00020,hsa00310 Citrate cycle (TCA cycle)|Lysine degradation DLX1 232.836862535045 231.107719966608 234.566005103482 1.01496395333472 0.0214284906925169 0.937637572267801 1 4.21846 4.17219 4.58817 4.04025 GeneID:1745,Genbank:NM_178120.4,HGNC:HGNC:2914,MIM:600029 distal-less homeobox 1 GO:0000122,GO:0000977,GO:0003682,GO:0005634,GO:0006351,GO:0009954,GO:0021544,GO:0021766,GO:0021882,GO:0021893,GO:0030514,GO:0042475,GO:0043524,GO:0045597,GO:0045746,GO:0045944,GO:0046533,GO:0048706,GO:0048715,GO:0071560,GO:0071773,GO:1902871,GO:1903845 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|chromatin binding|nucleus|transcription, DNA-templated|proximal/distal pattern formation|subpallium development|hippocampus development|regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment|cerebral cortex GABAergic interneuron fate commitment|negative regulation of BMP signaling pathway|odontogenesis of dentin-containing tooth|negative regulation of neuron apoptotic process|positive regulation of cell differentiation|negative regulation of Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|negative regulation of photoreceptor cell differentiation|embryonic skeletal system development|negative regulation of oligodendrocyte differentiation|cellular response to transforming growth factor beta stimulus|cellular response to BMP stimulus|positive regulation of amacrine cell differentiation|negative regulation of cellular response to transforming growth factor beta stimulus DLX2 20.5753579791888 19.8233701415033 21.3273458168743 1.07586881870415 0.105502179992614 0.874663332307721 1 0.6142 0.310051 0.614065 0.384751 GeneID:1746,Genbank:NM_004405.3,HGNC:HGNC:2915,MIM:126255 distal-less homeobox 2 GO:0000122,GO:0000977,GO:0001228,GO:0003682,GO:0003700,GO:0003727,GO:0005634,GO:0007420,GO:0009954,GO:0021544,GO:0021766,GO:0021772,GO:0021882,GO:0021893,GO:0042475,GO:0045597,GO:0045746,GO:0046533,GO:0048701,GO:0048715,GO:0048755,GO:0051216,GO:1902871 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|DNA binding transcription factor activity|single-stranded RNA binding|nucleus|brain development|proximal/distal pattern formation|subpallium development|hippocampus development|olfactory bulb development|regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment|cerebral cortex GABAergic interneuron fate commitment|odontogenesis of dentin-containing tooth|positive regulation of cell differentiation|negative regulation of Notch signaling pathway|negative regulation of photoreceptor cell differentiation|embryonic cranial skeleton morphogenesis|negative regulation of oligodendrocyte differentiation|branching morphogenesis of a nerve|cartilage development|positive regulation of amacrine cell differentiation DLX3 1.4647761204752 1.96028560782945 0.969266633120943 0.49445174175113 -1.01609837336455 0.813651560116793 1 0 0.0591327 0.0155099 0.0145062 GeneID:1747,Genbank:NM_005220.2,HGNC:HGNC:2916,MIM:600525 distal-less homeobox 3 GO:0001077,GO:0001568,GO:0001890,GO:0003682,GO:0003700,GO:0005634,GO:0042475,GO:0043565,GO:0071895 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|blood vessel development|placenta development|chromatin binding|DNA binding transcription factor activity|nucleus|odontogenesis of dentin-containing tooth|sequence-specific DNA binding|odontoblast differentiation DLX4 11.3589245310416 8.66739775606975 14.0504513060134 1.62106917225229 0.696945653061605 0.441520020995121 1 0.117107 0.154808 0.126576 0.220755 GeneID:1748,Genbank:XM_017024291.1,HGNC:HGNC:2917,MIM:601911 distal-less homeobox 4 DLX5 123.360537063491 104.729167193111 141.991906933871 1.35580097445109 0.439145412805872 0.107880273518256 1 1.07683 1.01668 1.52668 1.42558 GeneID:1749,Genbank:NM_005221.5,HGNC:HGNC:2918,MIM:600028 distal-less homeobox 5 hsa04550 Signaling pathways regulating pluripotency of stem cells DLX6 191.850034867934 176.749028969773 206.951040766096 1.17087512147797 0.227587214838627 0.323603764400164 1 3.75949 3.47822 4.79425 3.86888 GeneID:1750,Genbank:NM_005222.3,HGNC:HGNC:2919,MIM:600030 distal-less homeobox 6 GO:0001501,GO:0003700,GO:0005634,GO:0007399,GO:0030326,GO:0030855,GO:0042472,GO:0043565,GO:0048646,GO:0050679,GO:0060021,GO:0060322 skeletal system development|DNA binding transcription factor activity|nucleus|nervous system development|embryonic limb morphogenesis|epithelial cell differentiation|inner ear morphogenesis|sequence-specific DNA binding|anatomical structure formation involved in morphogenesis|positive regulation of epithelial cell proliferation|palate development|head development DMAC1 1472.96278252884 1436.00824422754 1509.91732083015 1.05146842081144 0.0724055216599296 0.750625617966669 1 17.9516 20.2586 17.7416 22.4702 GeneID:90871,Genbank:NM_001318059.1,HGNC:HGNC:30536,MIM:617261 distal membrane arm assembly complex 1 GO:0005743,GO:0016021,GO:0032981 mitochondrial inner membrane|integral component of membrane|mitochondrial respiratory chain complex I assembly DMAC2 1469.15841656916 1501.44647237066 1436.87036076766 0.95699073340854 -0.0634231398001685 0.648780720670472 1 22.6864 24.1551 21.9255 23.5674 GeneID:55101,Genbank:XM_011527065.2,HGNC:HGNC:25496,MIM:617262 distal membrane arm assembly complex 2 GO:0005739,GO:0032981 mitochondrion|mitochondrial respiratory chain complex I assembly DMAP1 797.76803851287 787.712801377146 807.823275648595 1.02553021131089 0.0363699931014194 0.823534205148465 1 12.1757 11.5789 12.7137 13.2356 GeneID:55929,Genbank:XM_024448403.1,HGNC:HGNC:18291,MIM:605077 DNA methyltransferase 1 associated protein 1 GO:0000122,GO:0001103,GO:0003714,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005829,GO:0006281,GO:0006306,GO:0006338,GO:0006351,GO:0035267,GO:0040008,GO:0042993,GO:0043967,GO:0043968,GO:0045471,GO:0045892 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II repressing transcription factor binding|transcription corepressor activity|nucleus|nucleoplasm|replication fork|cytoplasm|cytosol|DNA repair|DNA methylation|chromatin remodeling|transcription, DNA-templated|NuA4 histone acetyltransferase complex|regulation of growth|positive regulation of transcription factor import into nucleus|histone H4 acetylation|histone H2A acetylation|response to ethanol|negative regulation of transcription, DNA-templated DMBT1 18.71540003016 20.4673290226234 16.9634710376966 0.828807267374562 -0.270891441574197 0.706122628894513 1 0.0768276 0.094734 0.0817451 0.0625328 GeneID:1755,Genbank:NM_007329.2,HGNC:HGNC:2926,MIM:601969 deleted in malignant brain tumors 1 hsa04970 Salivary secretion DMBX1 9.76909253067863 10.3297170606816 9.20846800067565 0.891454039503773 -0.1657676758248 0.924387016918248 1 0.176396 0.107624 0.146697 0.107026 GeneID:127343,Genbank:XM_017000289.1,HGNC:HGNC:19026,MIM:607410 diencephalon/mesencephalon homeobox 1 GO:0000977,GO:0001227,GO:0003677,GO:0003700,GO:0005634,GO:0005667,GO:0006351,GO:0007417,GO:0007420,GO:0008343,GO:0008344,GO:0042803,GO:0043565,GO:0045892,GO:0046982,GO:0048589 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|transcription factor complex|transcription, DNA-templated|central nervous system development|brain development|adult feeding behavior|adult locomotory behavior|protein homodimerization activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|protein heterodimerization activity|developmental growth DMD 94.6193833062932 102.960986684021 86.2777799285649 0.837965745154949 -0.255036825073908 0.418635205329316 1 0.129225 0.110843 0.119975 0.0800047 GeneID:1756,Genbank:XM_006724469.3,HGNC:HGNC:2928,MIM:300377 dystrophin GO:0001954,GO:0002027,GO:0002162,GO:0003779,GO:0005178,GO:0005521,GO:0005634,GO:0005741,GO:0005794,GO:0005840,GO:0005883,GO:0005886,GO:0006355,GO:0007517,GO:0007519,GO:0007568,GO:0008065,GO:0008270,GO:0008284,GO:0008307,GO:0009414,GO:0009986,GO:0010468,GO:0010880,GO:0010881,GO:0010976,GO:0014069,GO:0014809,GO:0014819,GO:0014894,GO:0014904,GO:0016010,GO:0017022,GO:0017166,GO:0021629,GO:0021987,GO:0030016,GO:0030018,GO:0030027,GO:0030054,GO:0030055,GO:0030141,GO:0030154,GO:0030165,GO:0030175,GO:0030182,GO:0030424,GO:0030672,GO:0031527,GO:0032403,GO:0033137,GO:0034613,GO:0035994,GO:0042383,GO:0042391,GO:0042692,GO:0042995,GO:0043005,GO:0043025,GO:0043034,GO:0043043,GO:0043234,GO:0043403,GO:0043623,GO:0044306,GO:0045121,GO:0045202,GO:0045211,GO:0045213,GO:0045665,GO:0045666,GO:0046716,GO:0048471,GO:0048747,GO:0048812,GO:0050998,GO:0051647,GO:0051726,GO:0060048,GO:0060314,GO:0060857,GO:0070373,GO:0086001,GO:0090287,GO:0097449,GO:0099617,GO:1901385,GO:1902083,GO:2000651 positive regulation of cell-matrix adhesion|regulation of heart rate|dystroglycan binding|actin binding|integrin binding|lamin binding|nucleus|mitochondrial outer membrane|Golgi apparatus|ribosome|neurofilament|plasma membrane|regulation of transcription, DNA-templated|muscle organ development|skeletal muscle tissue development|aging|establishment of blood-nerve barrier|zinc ion binding|positive regulation of cell proliferation|structural constituent of muscle|response to water deprivation|cell surface|regulation of gene expression|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|positive regulation of neuron projection development|postsynaptic density|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|regulation of skeletal muscle contraction|response to denervation involved in regulation of muscle adaptation|myotube cell development|dystrophin-associated glycoprotein complex|myosin binding|vinculin binding|olfactory nerve structural organization|cerebral cortex development|myofibril|Z disc|lamellipodium|cell junction|cell-substrate junction|secretory granule|cell differentiation|PDZ domain binding|filopodium|neuron differentiation|axon|synaptic vesicle membrane|filopodium membrane|protein complex binding|negative regulation of peptidyl-serine phosphorylation|cellular protein localization|response to muscle stretch|sarcolemma|regulation of membrane potential|muscle cell differentiation|cell projection|neuron projection|neuronal cell body|costamere|peptide biosynthetic process|protein complex|skeletal muscle tissue regeneration|cellular protein complex assembly|neuron projection terminus|membrane raft|synapse|postsynaptic membrane|neurotransmitter receptor metabolic process|negative regulation of neuron differentiation|positive regulation of neuron differentiation|muscle cell cellular homeostasis|perinuclear region of cytoplasm|muscle fiber development|neuron projection morphogenesis|nitric-oxide synthase binding|nucleus localization|regulation of cell cycle|cardiac muscle contraction|regulation of ryanodine-sensitive calcium-release channel activity|establishment of glial blood-brain barrier|negative regulation of ERK1 and ERK2 cascade|cardiac muscle cell action potential|regulation of cellular response to growth factor stimulus|astrocyte projection|matrix side of mitochondrial inner membrane|regulation of voltage-gated calcium channel activity|negative regulation of peptidyl-cysteine S-nitrosylation|positive regulation of sodium ion transmembrane transporter activity hsa05410,hsa05412,hsa05414,hsa05416 Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Viral myocarditis DMGDH 2.42903965422595 0.980142803914724 3.87793650453717 3.95650153125499 1.98422531557958 0.42419904207777 1 0 0.00497457 0.0249362 0.00928335 GeneID:29958,Genbank:NM_013391.3,HGNC:HGNC:24475,MIM:605849 dimethylglycine dehydrogenase GO:0003723,GO:0005739,GO:0005759,GO:0006579,GO:0009055,GO:0019695,GO:0042426,GO:0047865 RNA binding|mitochondrion|mitochondrial matrix|amino-acid betaine catabolic process|electron transfer activity|choline metabolic process|choline catabolic process|dimethylglycine dehydrogenase activity hsa00260 Glycine, serine and threonine metabolism DMKN 7.67060117021795 7.10113100082778 8.24007133960811 1.16038858298031 0.214608006096052 0.915505819149726 1 0.0308953 0.0827352 0 0.0270546 GeneID:93099,Genbank:NM_001190347.1,HGNC:HGNC:25063,MIM:617211 dermokine GO:0070062,GO:1903575 extracellular exosome|cornified envelope assembly DMPK 1042.89772761054 991.003138292625 1094.79231692845 1.10473143285363 0.143695684020832 0.357692080037451 1 8.60696 8.82221 10.8335 9.8393 GeneID:1760,Genbank:NM_001288766.1,HGNC:HGNC:2933,MIM:605377 DM1 protein kinase GO:0002028,GO:0004674,GO:0005524,GO:0005640,GO:0005789,GO:0005829,GO:0005886,GO:0006468,GO:0006874,GO:0006998,GO:0008016,GO:0010657,GO:0010830,GO:0014722,GO:0014853,GO:0017020,GO:0018105,GO:0031072,GO:0031307,GO:0031965,GO:0033017,GO:0046872,GO:0051823,GO:1903779 regulation of sodium ion transport|protein serine/threonine kinase activity|ATP binding|nuclear outer membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|protein phosphorylation|cellular calcium ion homeostasis|nuclear envelope organization|regulation of heart contraction|muscle cell apoptotic process|regulation of myotube differentiation|regulation of skeletal muscle contraction by calcium ion signaling|regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction|myosin phosphatase regulator activity|peptidyl-serine phosphorylation|heat shock protein binding|integral component of mitochondrial outer membrane|nuclear membrane|sarcoplasmic reticulum membrane|metal ion binding|regulation of synapse structural plasticity|regulation of cardiac conduction DMRT1 2.96039428739126 1.07619535328461 4.84459322149792 4.50159277004119 2.17043555141328 0.284157577688255 1 0 0 0.0403898 0.094449 GeneID:1761,Genbank:XM_006716732.1,HGNC:HGNC:2934,MIM:602424 doublesex and mab-3 related transcription factor 1 GO:0000122,GO:0000902,GO:0000977,GO:0000987,GO:0001228,GO:0002176,GO:0003682,GO:0005634,GO:0005737,GO:0007283,GO:0008354,GO:0030238,GO:0035556,GO:0042802,GO:0042803,GO:0045835,GO:0045840,GO:0045944,GO:0046661,GO:0046872,GO:0046982,GO:0048599,GO:0060008,GO:0060009,GO:0060903,GO:1900107,GO:2000020 negative regulation of transcription from RNA polymerase II promoter|cell morphogenesis|RNA polymerase II regulatory region sequence-specific DNA binding|proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|male germ cell proliferation|chromatin binding|nucleus|cytoplasm|spermatogenesis|germ cell migration|male sex determination|intracellular signal transduction|identical protein binding|protein homodimerization activity|negative regulation of meiotic nuclear division|positive regulation of mitotic nuclear division|positive regulation of transcription from RNA polymerase II promoter|male sex differentiation|metal ion binding|protein heterodimerization activity|oocyte development|Sertoli cell differentiation|Sertoli cell development|positive regulation of meiosis I|regulation of nodal signaling pathway|positive regulation of male gonad development DMRT2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0076216 0 0 0 GeneID:10655,Genbank:XM_011517690.2,HGNC:HGNC:2935,MIM:604935 doublesex and mab-3 related transcription factor 2 GO:0000977,GO:0003700,GO:0005634,GO:0006351,GO:0014807,GO:0042803,GO:0045944,GO:0046872,GO:0048706,GO:2000287 RNA polymerase II regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of somitogenesis|protein homodimerization activity|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|embryonic skeletal system development|positive regulation of myotome development DMRTA1 201.211651582997 200.319465537556 202.103837628437 1.0089076320471 0.0127940982426084 0.939070572765891 1 4.82129 3.42086 4.76121 3.85743 GeneID:63951,Genbank:NM_022160.2,HGNC:HGNC:13826,MIM:614803 DMRT like family A1 GO:0001541,GO:0003700,GO:0005634,GO:0006351,GO:0042803,GO:0043565,GO:0046872,GO:0060179 ovarian follicle development|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|protein homodimerization activity|sequence-specific DNA binding|metal ion binding|male mating behavior DMRTA2 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0.0161436 0.0301058 GeneID:63950,Genbank:XM_011541937.2,HGNC:HGNC:13908,MIM:614804 DMRT like family A2 GO:0002052,GO:0003700,GO:0005634,GO:0007420,GO:0021796,GO:0035914,GO:0042803,GO:0043565,GO:0046872,GO:0046982,GO:0048665,GO:0071542 positive regulation of neuroblast proliferation|DNA binding transcription factor activity|nucleus|brain development|cerebral cortex regionalization|skeletal muscle cell differentiation|protein homodimerization activity|sequence-specific DNA binding|metal ion binding|protein heterodimerization activity|neuron fate specification|dopaminergic neuron differentiation DMTF1 455.996248453999 476.743060201704 435.249436706294 0.91296438908234 -0.131369507072468 0.635096312510824 1 2.21567 1.82009 2.15028 1.61643 GeneID:9988,Genbank:NM_001142327.1,HGNC:HGNC:14603,MIM:608491 cyclin D binding myb like transcription factor 1 DMTN 815.762351568582 815.974263557257 815.550439579907 0.999480591488875 -0.00074954275949492 0.97888886276138 1 5.66021 6.35148 5.69381 6.78162 GeneID:2039,Genbank:NM_001323397.1,HGNC:HGNC:3382,MIM:125305 dematin actin binding protein GO:0003779,GO:0005102,GO:0005829,GO:0005884,GO:0005886,GO:0006461,GO:0007010,GO:0008360,GO:0010591,GO:0010763,GO:0010801,GO:0010812,GO:0012505,GO:0014069,GO:0014731,GO:0015629,GO:0030036,GO:0030194,GO:0030507,GO:0030863,GO:0031095,GO:0031253,GO:0031410,GO:0032956,GO:0033137,GO:0035584,GO:0035585,GO:0043621,GO:0048471,GO:0048821,GO:0050732,GO:0051017,GO:0051489,GO:0051693,GO:0051895,GO:0055085,GO:0070560,GO:0071277,GO:0071320,GO:0090303,GO:0090315,GO:0090527,GO:1900025,GO:1900026,GO:1901731,GO:2001046 actin binding|receptor binding|cytosol|actin filament|plasma membrane|protein complex assembly|cytoskeleton organization|regulation of cell shape|regulation of lamellipodium assembly|positive regulation of fibroblast migration|negative regulation of peptidyl-threonine phosphorylation|negative regulation of cell-substrate adhesion|endomembrane system|postsynaptic density|spectrin-associated cytoskeleton|actin cytoskeleton|actin cytoskeleton organization|positive regulation of blood coagulation|spectrin binding|cortical cytoskeleton|platelet dense tubular network membrane|cell projection membrane|cytoplasmic vesicle|regulation of actin cytoskeleton organization|negative regulation of peptidyl-serine phosphorylation|calcium-mediated signaling using intracellular calcium source|calcium-mediated signaling using extracellular calcium source|protein self-association|perinuclear region of cytoplasm|erythrocyte development|negative regulation of peptidyl-tyrosine phosphorylation|actin filament bundle assembly|regulation of filopodium assembly|actin filament capping|negative regulation of focal adhesion assembly|transmembrane transport|protein secretion by platelet|cellular response to calcium ion|cellular response to cAMP|positive regulation of wound healing|negative regulation of protein targeting to membrane|actin filament reorganization|negative regulation of substrate adhesion-dependent cell spreading|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of platelet aggregation|positive regulation of integrin-mediated signaling pathway DMWD 1355.10744851227 1321.31496986187 1388.89992716268 1.05114977037449 0.0719682426421648 0.641718916529765 1 17.4667 17.4211 18.5358 18.2991 GeneID:1762,Genbank:NM_004943.1,HGNC:HGNC:2936,MIM:609857 DM1 locus, WD repeat containing GO:0005634,GO:0016579,GO:0030425,GO:0043204 nucleus|protein deubiquitination|dendrite|perikaryon DMXL1 255.526326641232 249.777442514818 261.275210767645 1.04603205212234 0.064927058783216 0.863257510148359 1 0.728394 0.596693 0.891964 0.526552 GeneID:1657,Genbank:XM_011543213.2,HGNC:HGNC:2937,MIM:605671 Dmx like 1 GO:0007035,GO:0043291,GO:0070072 vacuolar acidification|RAVE complex|vacuolar proton-transporting V-type ATPase complex assembly DMXL2 209.649636207874 206.978551411112 212.320721004637 1.02581025694259 0.036763901819002 0.923793380774643 1 0.771813 0.554446 0.875201 0.455344 GeneID:23312,Genbank:NM_001174117.1,HGNC:HGNC:2938,MIM:612186 Dmx like 2 GO:0005615,GO:0007035,GO:0008021,GO:0017137,GO:0030054,GO:0030672,GO:0043291,GO:0070072 extracellular space|vacuolar acidification|synaptic vesicle|Rab GTPase binding|cell junction|synaptic vesicle membrane|RAVE complex|vacuolar proton-transporting V-type ATPase complex assembly DNA2 330.474391324259 363.846375309588 297.102407338931 0.816560030551722 -0.292369143459583 0.229647828856553 1 2.90303 2.47993 2.40035 1.98022 GeneID:1763,Genbank:XM_006717680.3,HGNC:HGNC:2939,MIM:601810 DNA replication helicase/nuclease 2 GO:0000076,GO:0000723,GO:0000729,GO:0000731,GO:0000732,GO:0000784,GO:0003677,GO:0003678,GO:0004386,GO:0004518,GO:0005524,GO:0005634,GO:0005654,GO:0005739,GO:0006260,GO:0006264,GO:0006284,GO:0016887,GO:0016890,GO:0017108,GO:0032201,GO:0033567,GO:0042645,GO:0043137,GO:0043139,GO:0043142,GO:0043504,GO:0044806,GO:0045740,GO:0046872,GO:0051539,GO:0090305,GO:0090656,GO:1901796,GO:1902990 DNA replication checkpoint|telomere maintenance|DNA double-strand break processing|DNA synthesis involved in DNA repair|strand displacement|nuclear chromosome, telomeric region|DNA binding|DNA helicase activity|helicase activity|nuclease activity|ATP binding|nucleus|nucleoplasm|mitochondrion|DNA replication|mitochondrial DNA replication|base-excision repair|ATPase activity|site-specific endodeoxyribonuclease activity, specific for altered base|5'-flap endonuclease activity|telomere maintenance via semi-conservative replication|DNA replication, Okazaki fragment processing|mitochondrial nucleoid|DNA replication, removal of RNA primer|5'-3' DNA helicase activity|single-stranded DNA-dependent ATPase activity|mitochondrial DNA repair|G-quadruplex DNA unwinding|positive regulation of DNA replication|metal ion binding|4 iron, 4 sulfur cluster binding|nucleic acid phosphodiester bond hydrolysis|t-circle formation|regulation of signal transduction by p53 class mediator|mitotic telomere maintenance via semi-conservative replication hsa03030 DNA replication DNAAF1 5.93296970365641 4.11267631439867 7.75326309291415 1.88521111320374 0.914726091089636 0.487357422829712 1 0.0216165 0.026137 0.0473825 0.0189797 GeneID:123872,Genbank:NM_178452.5,HGNC:HGNC:30539,MIM:613190 dynein axonemal assembly factor 1 GO:0000922,GO:0001947,GO:0003341,GO:0003356,GO:0005737,GO:0005829,GO:0005886,GO:0005930,GO:0016607,GO:0030324,GO:0035469,GO:0036158,GO:0036159,GO:0044458,GO:0060271,GO:0060287,GO:0060972,GO:0070286,GO:0070840,GO:0071907,GO:0071910 spindle pole|heart looping|cilium movement|regulation of cilium beat frequency|cytoplasm|cytosol|plasma membrane|axoneme|nuclear speck|lung development|determination of pancreatic left/right asymmetry|outer dynein arm assembly|inner dynein arm assembly|motile cilium assembly|cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry|left/right pattern formation|axonemal dynein complex assembly|dynein complex binding|determination of digestive tract left/right asymmetry|determination of liver left/right asymmetry DNAAF2 228.236304175144 228.705389231506 227.767219118781 0.995897909901127 -0.00593023655810378 0.988100105430718 1 3.56018 3.64094 3.57594 3.5663 GeneID:55172,Genbank:NM_001083908.1,HGNC:HGNC:20188,MIM:612517 dynein axonemal assembly factor 2 GO:0005737,GO:0005829,GO:0060285,GO:0070286 cytoplasm|cytosol|cilium-dependent cell motility|axonemal dynein complex assembly DNAAF3 41.1654322525755 45.9794508888753 36.3514136162756 0.790601299352855 -0.338977768659281 0.447571200895177 1 0.686472 0.62562 0.672648 0.334983 GeneID:352909,Genbank:NM_001256715.1,HGNC:HGNC:30492,MIM:614566 dynein axonemal assembly factor 3 GO:0005737,GO:0044458,GO:0070286 cytoplasm|motile cilium assembly|axonemal dynein complex assembly DNAAF4 33.4019951664174 30.9411249073599 35.8628654254749 1.15906792441616 0.212965114529838 0.675626944417027 1 0.343403 0.302285 0.396653 0.397699 GeneID:161582,Genbank:NM_001033560.1,HGNC:HGNC:21493,MIM:608706 dynein axonemal assembly factor 4 GO:0001764,GO:0003341,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0007368,GO:0030331,GO:0033146,GO:0036158,GO:0036159,GO:0061136,GO:0097730 neuron migration|cilium movement|nucleus|cytoplasm|centrosome|cytosol|plasma membrane|determination of left/right symmetry|estrogen receptor binding|regulation of intracellular estrogen receptor signaling pathway|outer dynein arm assembly|inner dynein arm assembly|regulation of proteasomal protein catabolic process|non-motile cilium DNAAF5 2156.95560575655 2305.60118735114 2008.31002416195 0.871056987296774 -0.19916098731351 0.147027133212347 1 28.8551 30.1526 27.0158 25.4494 GeneID:54919,Genbank:XM_024446813.1,HGNC:HGNC:26013,MIM:614864 dynein axonemal assembly factor 5 GO:0003341,GO:0005737,GO:0036158,GO:0036159,GO:0045505 cilium movement|cytoplasm|outer dynein arm assembly|inner dynein arm assembly|dynein intermediate chain binding DNAH1 54.8630989987627 58.3655061067563 51.3606918907692 0.879983663584197 -0.184451353733827 0.645715596542615 1 0.0833683 0.0834366 0.0657234 0.0803406 GeneID:25981,Genbank:XM_017006132.1,HGNC:HGNC:2940,MIM:603332 dynein axonemal heavy chain 1 GO:0003341,GO:0003777,GO:0005524,GO:0005858,GO:0005874,GO:0005930,GO:0007288,GO:0008569,GO:0030317,GO:0036126,GO:0036156,GO:0036159,GO:0045503,GO:0045505,GO:0051959,GO:0060285 cilium movement|microtubule motor activity|ATP binding|axonemal dynein complex|microtubule|axoneme|sperm axoneme assembly|ATP-dependent microtubule motor activity, minus-end-directed|flagellated sperm motility|sperm flagellum|inner dynein arm|inner dynein arm assembly|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility hsa05016 Huntington disease DNAH10 13.2751975102426 13.4622505711655 13.0881444493196 0.972210729560537 -0.0406590387300509 1 1 0.020458 0.011792 0.014602 0.0158192 GeneID:196385,Genbank:XM_011538020.2,HGNC:HGNC:2941,MIM:605884 dynein axonemal heavy chain 10 GO:0005524,GO:0005737,GO:0005874,GO:0005929,GO:0007018,GO:0008569,GO:0030286,GO:0045503,GO:0045505,GO:0051959 ATP binding|cytoplasm|microtubule|cilium|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding hsa05016 Huntington disease DNAH11 45.12510217465 54.3969086164124 35.8532957328875 0.659105391185226 -0.601418923761138 0.159650366179564 1 0.0974519 0.0993628 0.0541363 0.0800431 GeneID:8701,Genbank:NM_001277115.1,HGNC:HGNC:2942,MIM:603339 dynein axonemal heavy chain 11 GO:0003341,GO:0003356,GO:0005524,GO:0005874,GO:0005930,GO:0007368,GO:0007507,GO:0008569,GO:0030286,GO:0030317,GO:0031514,GO:0045503,GO:0045505,GO:0051959 cilium movement|regulation of cilium beat frequency|ATP binding|microtubule|axoneme|determination of left/right symmetry|heart development|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|flagellated sperm motility|motile cilium|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding hsa05016 Huntington disease DNAH12 1.21180078441453 0 2.42360156882906 Inf Inf 0.339528558269803 1 0 0 0.00262946 0.00244013 GeneID:201625,Genbank:XM_017005861.1,HGNC:HGNC:2943,MIM:603340 dynein axonemal heavy chain 12 GO:0003777,GO:0005524,GO:0005737,GO:0005874,GO:0005929,GO:0007018,GO:0016887,GO:0030286 microtubule motor activity|ATP binding|cytoplasm|microtubule|cilium|microtubule-based movement|ATPase activity|dynein complex hsa05016 Huntington disease DNAH14 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00193246 0 0 0 GeneID:127602,Genbank:XM_011544071.2,HGNC:HGNC:2945,MIM:603341 dynein axonemal heavy chain 14 GO:0005524,GO:0005737,GO:0005874,GO:0005929,GO:0007018,GO:0008569,GO:0030286,GO:0045503,GO:0045505,GO:0051959,GO:0060271 ATP binding|cytoplasm|microtubule|cilium|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding|cilium assembly hsa05016 Huntington disease DNAH17 16.4139307117017 21.1975317980055 11.6303296253979 0.548664332065878 -0.866004303705504 0.232047945618966 1 0.0196697 0.0109222 0.016142 0.00858735 GeneID:8632,Genbank:NM_173628.3,HGNC:HGNC:2946,MIM:610063 dynein axonemal heavy chain 17 GO:0003341,GO:0003777,GO:0005524,GO:0005858,GO:0005874,GO:0005930,GO:0008569,GO:0030286,GO:0031514,GO:0045503,GO:0045505,GO:0051959,GO:0060285 cilium movement|microtubule motor activity|ATP binding|axonemal dynein complex|microtubule|axoneme|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|motile cilium|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility hsa05016 Huntington disease DNAH2 2.70309159191729 2.49838328447175 2.90779989936283 1.16387262012027 0.21893317132456 1 1 0.0022941 0.00412364 0.00648291 0.00602741 GeneID:146754,Genbank:NM_020877.3,HGNC:HGNC:2948,MIM:603333 dynein axonemal heavy chain 2 GO:0003777,GO:0005524,GO:0005858,GO:0005874,GO:0007018,GO:0008569,GO:0030286,GO:0031514,GO:0045503,GO:0045505,GO:0051959,GO:0060285 microtubule motor activity|ATP binding|axonemal dynein complex|microtubule|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|motile cilium|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility hsa05016 Huntington disease DNAH3 1.72458036563427 1.02816907859967 2.42099165266886 2.35466296649008 1.23552057517975 0.734582532185275 1 0 0.00221721 0 0.00636176 GeneID:55567,Genbank:XM_017023432.1,HGNC:HGNC:2949,MIM:603334 dynein axonemal heavy chain 3 GO:0003341,GO:0003777,GO:0005524,GO:0005858,GO:0005874,GO:0008569,GO:0036156,GO:0036159,GO:0045503,GO:0045505,GO:0051959,GO:0060285 cilium movement|microtubule motor activity|ATP binding|axonemal dynein complex|microtubule|ATP-dependent microtubule motor activity, minus-end-directed|inner dynein arm|inner dynein arm assembly|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility hsa05016 Huntington disease DNAH5 32.6932214246072 39.2145038108421 26.1719390383723 0.6674045696107 -0.583366530434666 0.252023585517706 1 0.0540453 0.0394085 0.0311743 0.0209139 GeneID:1767,Genbank:XM_017009177.1,HGNC:HGNC:2950,MIM:603335 dynein axonemal heavy chain 5 GO:0003341,GO:0005524,GO:0005874,GO:0005930,GO:0007368,GO:0008569,GO:0030317,GO:0036157,GO:0036158,GO:0045503,GO:0045505,GO:0051959,GO:0060271 cilium movement|ATP binding|microtubule|axoneme|determination of left/right symmetry|ATP-dependent microtubule motor activity, minus-end-directed|flagellated sperm motility|outer dynein arm|outer dynein arm assembly|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding|cilium assembly hsa05016 Huntington disease DNAH6 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.00249079 0.00251143 0.00232941 GeneID:1768,Genbank:XM_011532649.3,HGNC:HGNC:2951,MIM:603336 dynein axonemal heavy chain 6 GO:0001539,GO:0005524,GO:0005858,GO:0005874,GO:0005929,GO:0007018,GO:0008569,GO:0030286,GO:0045503,GO:0045505,GO:0051959,GO:0060271 cilium or flagellum-dependent cell motility|ATP binding|axonemal dynein complex|microtubule|cilium|microtubule-based movement|ATP-dependent microtubule motor activity, minus-end-directed|dynein complex|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding|cilium assembly hsa05016 Huntington disease DNAH7 4.50982593479445 5.14084539299833 3.87880647659057 0.754507513856257 -0.406392826807129 0.850491088123243 1 0.0149879 0.0144379 0.00868887 0.00536859 GeneID:56171,Genbank:XM_011511488.3,HGNC:HGNC:18661,MIM:610061 dynein axonemal heavy chain 7 GO:0003341,GO:0003777,GO:0005509,GO:0005524,GO:0005829,GO:0005858,GO:0005874,GO:0005929,GO:0008569,GO:0036156,GO:0036159,GO:0045503,GO:0045505,GO:0051959,GO:0060285 cilium movement|microtubule motor activity|calcium ion binding|ATP binding|cytosol|axonemal dynein complex|microtubule|cilium|ATP-dependent microtubule motor activity, minus-end-directed|inner dynein arm|inner dynein arm assembly|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding|cilium-dependent cell motility hsa05016 Huntington disease DNAH9 11.5973255550184 7.68725495215503 15.5073961578817 2.01728656775386 1.01241604206237 0.243343282686161 1 0.0145924 0.0133508 0.0299379 0.0300093 GeneID:1770,Genbank:NM_001372.3,HGNC:HGNC:2953,MIM:603330 dynein axonemal heavy chain 9 GO:0003341,GO:0005524,GO:0005874,GO:0005930,GO:0008569,GO:0030030,GO:0030286,GO:0031514,GO:0045503,GO:0045505,GO:0051959 cilium movement|ATP binding|microtubule|axoneme|ATP-dependent microtubule motor activity, minus-end-directed|cell projection organization|dynein complex|motile cilium|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding hsa05016 Huntington disease DNAI1 3.74646420072404 3.13253351048394 4.36039489096415 1.39197070881151 0.47712885292731 0.831048559314407 1 0.0138939 0.00424871 0.00876907 0.0245368 GeneID:27019,Genbank:NM_001281428.1,HGNC:HGNC:2954,MIM:604366 dynein axonemal intermediate chain 1 GO:0003341,GO:0003774,GO:0005856,GO:0005874,GO:0005929,GO:0007368,GO:0030317,GO:0036157,GO:0036158,GO:0045503,GO:0045504 cilium movement|motor activity|cytoskeleton|microtubule|cilium|determination of left/right symmetry|flagellated sperm motility|outer dynein arm|outer dynein arm assembly|dynein light chain binding|dynein heavy chain binding hsa05016 Huntington disease DNAJA1 6460.39940277484 6426.20082007197 6494.59798547772 1.01064348396834 0.0152741598318697 0.899867437899144 1 95.4194 91.842 107.401 83.6535 GeneID:3301,Genbank:NM_001539.3,HGNC:HGNC:5229,MIM:602837 DnaJ heat shock protein family (Hsp40) member A1 GO:0001664,GO:0001671,GO:0005524,GO:0005634,GO:0005739,GO:0005783,GO:0005829,GO:0006457,GO:0007283,GO:0009408,GO:0016020,GO:0030317,GO:0030521,GO:0030544,GO:0030957,GO:0031397,GO:0031625,GO:0042769,GO:0043065,GO:0043066,GO:0043508,GO:0046872,GO:0048471,GO:0050750,GO:0051082,GO:0051087,GO:0051223,GO:0055131,GO:0070062,GO:0070585,GO:1901998,GO:1903748,GO:1905259 G-protein coupled receptor binding|ATPase activator activity|ATP binding|nucleus|mitochondrion|endoplasmic reticulum|cytosol|protein folding|spermatogenesis|response to heat|membrane|flagellated sperm motility|androgen receptor signaling pathway|Hsp70 protein binding|Tat protein binding|negative regulation of protein ubiquitination|ubiquitin protein ligase binding|DNA damage response, detection of DNA damage|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of JUN kinase activity|metal ion binding|perinuclear region of cytoplasm|low-density lipoprotein particle receptor binding|unfolded protein binding|chaperone binding|regulation of protein transport|C3HC4-type RING finger domain binding|extracellular exosome|protein localization to mitochondrion|toxin transport|negative regulation of establishment of protein localization to mitochondrion|negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway hsa04141 Protein processing in endoplasmic reticulum DNAJA2 2898.27550881686 2956.70852909602 2839.84248853769 0.96047427759338 -0.0581811172124699 0.676846226412459 1 36.2996 37.0735 35.4315 35.8853 GeneID:10294,Genbank:NM_005880.3,HGNC:HGNC:14884,MIM:611322 DnaJ heat shock protein family (Hsp40) member A2 GO:0001671,GO:0005524,GO:0005829,GO:0008284,GO:0009408,GO:0016020,GO:0031072,GO:0042026,GO:0046872,GO:0051082,GO:0051087,GO:0070062 ATPase activator activity|ATP binding|cytosol|positive regulation of cell proliferation|response to heat|membrane|heat shock protein binding|protein refolding|metal ion binding|unfolded protein binding|chaperone binding|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum DNAJA3 2067.49336540938 2164.10787335698 1970.87885746177 0.910711929717503 -0.134933312309622 0.322541076588518 1 27.3597 29.5571 25.4604 27.5012 GeneID:9093,Genbank:NM_005147.5,HGNC:HGNC:11808,MIM:608382 DnaJ heat shock protein family (Hsp40) member A3 hsa05203 Viral carcinogenesis DNAJA4 1.02816907859967 2.05633815719933 0 0 -Inf 0.409782672813165 1 0.0128507 0.0118299 0 0 GeneID:55466,Genbank:NM_018602.3,HGNC:HGNC:14885 DnaJ heat shock protein family (Hsp40) member A4 GO:0005524,GO:0005829,GO:0009408,GO:0016020,GO:0031072,GO:0042026,GO:0046872,GO:0051082,GO:0051087,GO:0090084 ATP binding|cytosol|response to heat|membrane|heat shock protein binding|protein refolding|metal ion binding|unfolded protein binding|chaperone binding|negative regulation of inclusion body assembly DNAJB1 9122.31344807265 8806.92330409666 9437.70359204863 1.0716232293812 0.0997977596690344 0.451102102532812 1 80.1568 83.2926 86.1503 91.1042 GeneID:3337,Genbank:NM_001313964.1,HGNC:HGNC:5270,MIM:604572 DnaJ heat shock protein family (Hsp40) member B1 GO:0001106,GO:0001671,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006986,GO:0030544,GO:0032781,GO:0045296,GO:0051082,GO:0051085,GO:0051087,GO:0051117,GO:0070062,GO:0090084,GO:0097201,GO:1900034 RNA polymerase II transcription corepressor activity|ATPase activator activity|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|response to unfolded protein|Hsp70 protein binding|positive regulation of ATPase activity|cadherin binding|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|ATPase binding|extracellular exosome|negative regulation of inclusion body assembly|negative regulation of transcription from RNA polymerase II promoter in response to stress|regulation of cellular response to heat hsa04141,hsa05164 Protein processing in endoplasmic reticulum|Influenza A DNAJB11 4211.63968548104 4364.36703324748 4058.9123377146 0.930011684808828 -0.104679252312018 0.445878081088807 1 96.0026 91.4842 93.6932 83.0151 GeneID:51726,Genbank:NM_016306.5,HGNC:HGNC:14889,MIM:611341 DnaJ heat shock protein family (Hsp40) member B11 GO:0005783,GO:0005788,GO:0006457,GO:0016020,GO:0032781,GO:0036498,GO:0051082 endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|membrane|positive regulation of ATPase activity|IRE1-mediated unfolded protein response|unfolded protein binding hsa04141 Protein processing in endoplasmic reticulum DNAJB12 2227.32922259782 2102.81952214698 2351.83892304865 1.11842167065646 0.161464219908356 0.249311028508592 1 16.3783 16.4784 18.1006 18.9634 GeneID:54788,Genbank:NM_017626.4,HGNC:HGNC:14891,MIM:608376 DnaJ heat shock protein family (Hsp40) member B12 GO:0005783,GO:0016020,GO:0030176,GO:0030544,GO:0031965,GO:0036503,GO:0043623,GO:0051085,GO:0071218 endoplasmic reticulum|membrane|integral component of endoplasmic reticulum membrane|Hsp70 protein binding|nuclear membrane|ERAD pathway|cellular protein complex assembly|chaperone cofactor-dependent protein refolding|cellular response to misfolded protein hsa04141 Protein processing in endoplasmic reticulum DNAJB13 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0 0 0 0.00751908 GeneID:374407,Genbank:NM_153614.3,HGNC:HGNC:30718,MIM:610263 DnaJ heat shock protein family (Hsp40) member B13 GO:0005930,GO:0006457,GO:0031514,GO:0036126,GO:0051082,GO:1904158 axoneme|protein folding|motile cilium|sperm flagellum|unfolded protein binding|axonemal central apparatus assembly DNAJB14 127.632230332038 129.241528945232 126.022931718844 0.975096261606806 -0.0363834459865425 0.953803504409771 1 0.929393 0.706315 0.980382 0.636947 GeneID:79982,Genbank:NM_001278310.1,HGNC:HGNC:25881,MIM:617487 DnaJ heat shock protein family (Hsp40) member B14 GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0030544,GO:0031965,GO:0043623,GO:0051085 endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|Hsp70 protein binding|nuclear membrane|cellular protein complex assembly|chaperone cofactor-dependent protein refolding DNAJB2 1501.21025728721 1507.94186210994 1494.47865246448 0.99107179793615 -0.0129385180262206 0.920768658058713 1 20.915 21.4584 20.2479 22.8759 GeneID:3300,Genbank:NM_006736.5,HGNC:HGNC:5228,MIM:604139 DnaJ heat shock protein family (Hsp40) member B2 GO:0001671,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0006986,GO:0008285,GO:0016234,GO:0030308,GO:0030433,GO:0030544,GO:0031227,GO:0031396,GO:0031398,GO:0031593,GO:0031625,GO:0031965,GO:0032091,GO:0032436,GO:0032781,GO:0032880,GO:0042026,GO:0043161,GO:0051082,GO:0051087,GO:0061077,GO:0070628,GO:0090084,GO:0090086,GO:1903644 ATPase activator activity|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|response to unfolded protein|negative regulation of cell proliferation|inclusion body|negative regulation of cell growth|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|intrinsic component of endoplasmic reticulum membrane|regulation of protein ubiquitination|positive regulation of protein ubiquitination|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|nuclear membrane|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ATPase activity|regulation of protein localization|protein refolding|proteasome-mediated ubiquitin-dependent protein catabolic process|unfolded protein binding|chaperone binding|chaperone-mediated protein folding|proteasome binding|negative regulation of inclusion body assembly|negative regulation of protein deubiquitination|regulation of chaperone-mediated protein folding hsa04141 Protein processing in endoplasmic reticulum DNAJB4 439.672141191512 485.775050845037 393.569231537986 0.810188236002131 -0.303670957758103 0.391269868055051 1 6.47269 4.85692 5.31417 3.80634 GeneID:11080,Genbank:NM_001317100.1,HGNC:HGNC:14886,MIM:611327 DnaJ heat shock protein family (Hsp40) member B4 GO:0001671,GO:0005654,GO:0005829,GO:0005886,GO:0006457,GO:0006986,GO:0009408,GO:0051082,GO:0051087,GO:0070062 ATPase activator activity|nucleoplasm|cytosol|plasma membrane|protein folding|response to unfolded protein|response to heat|unfolded protein binding|chaperone binding|extracellular exosome DNAJB5 365.516524764768 336.54848962574 394.484559903797 1.1721477649253 0.229154452257858 0.239719421333043 1 3.54233 4.14362 4.45748 4.19814 GeneID:25822,Genbank:NM_001349723.1,HGNC:HGNC:14887,MIM:611328 DnaJ heat shock protein family (Hsp40) member B5 GO:0000122,GO:0005634,GO:0005829,GO:0006457,GO:0006986,GO:0051082,GO:0051087 negative regulation of transcription from RNA polymerase II promoter|nucleus|cytosol|protein folding|response to unfolded protein|unfolded protein binding|chaperone binding DNAJB6 3222.67139083764 3416.68431742756 3028.65846424773 0.886432044306637 -0.173918059476504 0.203810198415782 1 34.3479 34.136 34.2998 30.952 GeneID:10049,Genbank:XM_017011633.1,HGNC:HGNC:14888,MIM:611332 DnaJ heat shock protein family (Hsp40) member B6 GO:0005634,GO:0030018,GO:0048471 nucleus|Z disc|perinuclear region of cytoplasm DNAJB7 2.75361941628733 3.084507235799 2.42273159677566 0.785451746929711 -0.348405446488833 0.96056761489562 1 0 0.0316191 0.0156922 0.014555 GeneID:150353,Genbank:NM_145174.1,HGNC:HGNC:24986,MIM:611336 DnaJ heat shock protein family (Hsp40) member B7 GO:0051087 chaperone binding DNAJB9 363.79070844977 397.507414565483 330.074002334057 0.830359359950209 -0.268192258890336 0.171315526328838 1 8.19999 7.68987 7.79204 5.58088 GeneID:4189,Genbank:NM_012328.2,HGNC:HGNC:6968,MIM:602634 DnaJ heat shock protein family (Hsp40) member B9 GO:0005730,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0030433,GO:0036498,GO:0051787,GO:0070062 nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|IRE1-mediated unfolded protein response|misfolded protein binding|extracellular exosome DNAJC1 654.023248626035 635.908370631659 672.13812662041 1.05697323334927 0.0799388425642846 0.621206806391179 1 6.04355 5.40409 5.38697 5.91153 GeneID:64215,Genbank:NM_022365.3,HGNC:HGNC:20090,MIM:611207 DnaJ heat shock protein family (Hsp40) member C1 GO:0001671,GO:0003677,GO:0005783,GO:0005789,GO:0005886,GO:0006417,GO:0006457,GO:0016020,GO:0016021,GO:0031965,GO:0045861,GO:0050708,GO:0051087 ATPase activator activity|DNA binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|regulation of translation|protein folding|membrane|integral component of membrane|nuclear membrane|negative regulation of proteolysis|regulation of protein secretion|chaperone binding hsa04141 Protein processing in endoplasmic reticulum DNAJC10 913.151547521152 915.08806326221 911.215031780094 0.995767586052529 -0.00611904092382941 0.991860242415122 1 5.69477 4.66943 6.13401 4.50793 GeneID:54431,Genbank:XM_024452971.1,HGNC:HGNC:24637,MIM:607987 DnaJ heat shock protein family (Hsp40) member C10 GO:0001671,GO:0001933,GO:0005783,GO:0005788,GO:0015035,GO:0015036,GO:0016020,GO:0016671,GO:0030433,GO:0030544,GO:0032781,GO:0034663,GO:0034975,GO:0034976,GO:0045454,GO:0051087,GO:0051117,GO:0051787,GO:0070059 ATPase activator activity|negative regulation of protein phosphorylation|endoplasmic reticulum|endoplasmic reticulum lumen|protein disulfide oxidoreductase activity|disulfide oxidoreductase activity|membrane|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|ubiquitin-dependent ERAD pathway|Hsp70 protein binding|positive regulation of ATPase activity|endoplasmic reticulum chaperone complex|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|cell redox homeostasis|chaperone binding|ATPase binding|misfolded protein binding|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress hsa04141 Protein processing in endoplasmic reticulum DNAJC11 2095.95400867979 2170.97664763778 2020.93136972181 0.930885816722518 -0.103323878500531 0.456926666302151 1 22.0872 22.5973 22.2037 20.5243 GeneID:55735,Genbank:NM_018198.3,HGNC:HGNC:25570,MIM:614827 DnaJ heat shock protein family (Hsp40) member C11 GO:0005739,GO:0005741,GO:0005743,GO:0042407,GO:0070062 mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|cristae formation|extracellular exosome DNAJC12 189.343252044887 189.682990519404 189.00351357037 0.996417828782786 -0.0051772591111083 0.99218921574666 1 1.89823 2.14239 2.5001 2.03429 GeneID:56521,Genbank:XM_017016432.2,HGNC:HGNC:28908,MIM:606060 DnaJ heat shock protein family (Hsp40) member C12 GO:0005737 cytoplasm DNAJC13 347.488989031681 344.503267914934 350.474710148427 1.01733348501927 0.0247926765592799 0.94232491271915 1 1.57561 1.30721 2.05831 1.06754 GeneID:23317,Genbank:NM_001329126.1,HGNC:HGNC:30343,MIM:614334 DnaJ heat shock protein family (Hsp40) member C13 GO:0001649,GO:0005765,GO:0005829,GO:0005886,GO:0006898,GO:0007032,GO:0010008,GO:0015031,GO:0016020,GO:0030667,GO:0031901,GO:0035577,GO:0043231,GO:0043312,GO:0070062,GO:1902954,GO:2000641 osteoblast differentiation|lysosomal membrane|cytosol|plasma membrane|receptor-mediated endocytosis|endosome organization|endosome membrane|protein transport|membrane|secretory granule membrane|early endosome membrane|azurophil granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|regulation of early endosome to recycling endosome transport|regulation of early endosome to late endosome transport DNAJC14 1417.75833491234 1440.87074062754 1394.64592919713 0.967918835377092 -0.0470420191936383 0.752530941922434 1 15.0634 16.1885 14.1987 16.2195 GeneID:85406,Genbank:NM_032364.5,HGNC:HGNC:24581,MIM:606092 DnaJ heat shock protein family (Hsp40) member C14 GO:0005789,GO:0015031,GO:0016020,GO:0016021,GO:0070062 endoplasmic reticulum membrane|protein transport|membrane|integral component of membrane|extracellular exosome DNAJC15 71.462799419238 67.3210615109357 75.6045373275403 1.12304434348913 0.167414893783786 0.635299430911869 1 0.715021 0.654959 0.865909 0.972044 GeneID:29103,Genbank:NM_013238.2,HGNC:HGNC:20325,MIM:615339 DnaJ heat shock protein family (Hsp40) member C15 GO:0005743,GO:0015031,GO:0016021 mitochondrial inner membrane|protein transport|integral component of membrane DNAJC16 416.385004464554 501.756319011745 331.013689917363 0.659710057203314 -0.600095996087092 0.00105327977388926 0.104778440115593 3.623 3.50417 2.50217 2.21524 GeneID:23341,Genbank:NM_015291.3,HGNC:HGNC:29157 DnaJ heat shock protein family (Hsp40) member C16 GO:0005829,GO:0016021,GO:0045454 cytosol|integral component of membrane|cell redox homeostasis DNAJC17 316.315943241394 301.157487480332 331.474399002455 1.1006679653751 0.138379321806615 0.477096372973939 1 1.7378 1.58446 1.62161 1.99419 GeneID:55192,Genbank:XM_017022401.2,HGNC:HGNC:25556,MIM:616844 DnaJ heat shock protein family (Hsp40) member C17 GO:0000122,GO:0003723,GO:0005634,GO:0005737,GO:0006351,GO:1901998 negative regulation of transcription from RNA polymerase II promoter|RNA binding|nucleus|cytoplasm|transcription, DNA-templated|toxin transport DNAJC18 508.721357549595 487.266916362835 530.175798736355 1.08806032368011 0.121758543961045 0.509238691522579 1 3.11425 3.88656 3.93451 3.92452 GeneID:202052,Genbank:NM_152686.3,HGNC:HGNC:28429 DnaJ heat shock protein family (Hsp40) member C18 GO:0016021 integral component of membrane DNAJC19 712.263730677133 755.80134232098 668.726119033286 0.88479085916903 -0.176591613812516 0.271835129617408 1 14.504 15.463 12.9753 14.6907 GeneID:131118,Genbank:NM_145261.3,HGNC:HGNC:30528,MIM:608977 DnaJ heat shock protein family (Hsp40) member C19 GO:0005739,GO:0005743,GO:0006457,GO:0006626,GO:0007601,GO:0016021,GO:0043234,GO:0048806 mitochondrion|mitochondrial inner membrane|protein folding|protein targeting to mitochondrion|visual perception|integral component of membrane|protein complex|genitalia development DNAJC2 313.635903207024 368.939194427902 258.332611986146 0.700203762266928 -0.514153281351083 0.0409345474101656 0.759435523043776 3.86567 3.17184 2.60317 2.12377 GeneID:27000,Genbank:NM_001129887.1,HGNC:HGNC:13192,MIM:605502 DnaJ heat shock protein family (Hsp40) member C2 GO:0001671,GO:0003677,GO:0003682,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006260,GO:0006351,GO:0016569,GO:0030544,GO:0031965,GO:0042393,GO:0045893,GO:0051083,GO:0061649,GO:1900034,GO:2000279 ATPase activator activity|DNA binding|chromatin binding|RNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA replication|transcription, DNA-templated|covalent chromatin modification|Hsp70 protein binding|nuclear membrane|histone binding|positive regulation of transcription, DNA-templated|'de novo' cotranslational protein folding|ubiquitin modification-dependent histone binding|regulation of cellular response to heat|negative regulation of DNA biosynthetic process DNAJC21 503.400404431808 506.599198101526 500.201610762091 0.987371501251068 -0.0183350900727905 0.94135200034877 1 1.65203 1.70625 1.94277 1.43054 GeneID:134218,Genbank:XM_011513965.2,HGNC:HGNC:27030,MIM:617048 DnaJ heat shock protein family (Hsp40) member C21 GO:0003723,GO:0005730,GO:0005840,GO:0006457,GO:0008270 RNA binding|nucleolus|ribosome|protein folding|zinc ion binding DNAJC22 689.223866769004 675.766833323621 702.680900214388 1.03982744574544 0.0563441400763296 0.725521897927569 1 5.59622 5.41668 5.57476 6.04867 GeneID:79962,Genbank:NM_001304944.1,HGNC:HGNC:25802 DnaJ heat shock protein family (Hsp40) member C22 GO:0016021 integral component of membrane DNAJC24 360.667464602821 417.465054875934 303.869874329709 0.727892959615545 -0.458201784553891 0.0173219384313544 0.545285272725254 5.70395 5.06805 4.29342 3.94379 GeneID:120526,Genbank:NM_181706.4,HGNC:HGNC:26979,MIM:611072 DnaJ heat shock protein family (Hsp40) member C24 GO:0001671,GO:0005737,GO:0005856,GO:0008198,GO:0008270,GO:0017183,GO:0032781,GO:0055114,GO:0061077 ATPase activator activity|cytoplasm|cytoskeleton|ferrous iron binding|zinc ion binding|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|positive regulation of ATPase activity|oxidation-reduction process|chaperone-mediated protein folding DNAJC25 104.836334607639 101.586825027519 108.085844187759 1.06397501997409 0.0894642796148989 0.753765607030376 1 2.08113 1.90011 2.51497 1.79222 GeneID:548645,Genbank:NM_001015882.2,HGNC:HGNC:34187 DnaJ heat shock protein family (Hsp40) member C25 GO:0016021 integral component of membrane DNAJC27 69.4430112717322 81.6958113011151 57.1902112423492 0.700038476043246 -0.514493876156492 0.361149675906476 1 0.757096 0.451199 0.499349 0.391577 GeneID:51277,Genbank:NM_001198559.1,HGNC:HGNC:30290,MIM:613527 DnaJ heat shock protein family (Hsp40) member C27 GO:0003924,GO:0005525,GO:0005634 GTPase activity|GTP binding|nucleus DNAJC28 10.173311814103 8.71542403075469 11.6311995974513 1.33455349463291 0.416357136049239 0.686243543837687 1 0.135198 0.111973 0.148928 0.207043 GeneID:54943,Genbank:NM_001320746.2,HGNC:HGNC:1297 DnaJ heat shock protein family (Hsp40) member C28 GO:0000301,GO:0006890,GO:0007030,GO:0017119,GO:0048213 retrograde transport, vesicle recycling within Golgi|retrograde vesicle-mediated transport, Golgi to ER|Golgi organization|Golgi transport complex|Golgi vesicle prefusion complex stabilization DNAJC3 573.877285227398 569.989879741695 577.764690713101 1.01364026142873 0.0195457340605732 0.92808303856616 1 3.61575 3.40907 4.29666 2.85343 GeneID:5611,Genbank:NM_006260.4,HGNC:HGNC:9439,MIM:601184 DnaJ heat shock protein family (Hsp40) member C3 hsa04141,hsa05164 Protein processing in endoplasmic reticulum|Influenza A DNAJC30 547.127734445816 504.015587923647 590.239880967984 1.17107465544776 0.2278330498879 0.223690382832721 1 9.32638 11.2787 11.6931 12.8531 GeneID:84277,Genbank:NM_032317.2,HGNC:HGNC:16410 DnaJ heat shock protein family (Hsp40) member C30 GO:0005739,GO:0005829 mitochondrion|cytosol DNAJC4 428.73167586112 383.98834606538 473.47500565686 1.23304524866034 0.302225742822737 0.100694321986035 1 10.0002 10.8935 12.3602 12.4893 GeneID:3338,Genbank:NM_005528.3,HGNC:HGNC:5271,MIM:604189 DnaJ heat shock protein family (Hsp40) member C4 GO:0006457,GO:0006986,GO:0016020,GO:0016021,GO:0051082 protein folding|response to unfolded protein|membrane|integral component of membrane|unfolded protein binding DNAJC5 4008.045613349 3760.60654639544 4255.48468030256 1.13159529661019 0.178358085407021 0.190639641183614 1 24.7405 25.7501 29.6515 28.7172 GeneID:80331,Genbank:NM_025219.2,HGNC:HGNC:16235,MIM:611203 DnaJ heat shock protein family (Hsp40) member C5 GO:0005739,GO:0005765,GO:0005886,GO:0006887,GO:0007269,GO:0008021,GO:0016020,GO:0016079,GO:0035577,GO:0035579,GO:0042470,GO:0043008,GO:0043195,GO:0043312,GO:0043524,GO:0045055,GO:0061202,GO:0070062 mitochondrion|lysosomal membrane|plasma membrane|exocytosis|neurotransmitter secretion|synaptic vesicle|membrane|synaptic vesicle exocytosis|azurophil granule membrane|specific granule membrane|melanosome|ATP-dependent protein binding|terminal bouton|neutrophil degranulation|negative regulation of neuron apoptotic process|regulated exocytosis|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum DNAJC5B 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0150138 0 0 GeneID:85479,Genbank:NM_001349432.1,HGNC:HGNC:24138,MIM:613945 DnaJ heat shock protein family (Hsp40) member C5 beta GO:0016020 membrane hsa04141 Protein processing in endoplasmic reticulum DNAJC5G 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0213178 0 0 GeneID:285126,Genbank:NM_001303127.1,HGNC:HGNC:24844,MIM:613946 DnaJ heat shock protein family (Hsp40) member C5 gamma GO:0016020 membrane hsa04141 Protein processing in endoplasmic reticulum DNAJC6 440.48939179608 411.353875334129 469.624908258031 1.14165670100123 0.191128893939868 0.27617373048427 1 2.37659 2.13095 2.78342 2.43473 GeneID:9829,Genbank:NM_001256865.1,HGNC:HGNC:15469,MIM:608375 DnaJ heat shock protein family (Hsp40) member C6 GO:0004725,GO:0005829,GO:0006898,GO:0014069,GO:0016191,GO:0017124,GO:0031982,GO:0061024,GO:2000369 protein tyrosine phosphatase activity|cytosol|receptor-mediated endocytosis|postsynaptic density|synaptic vesicle uncoating|SH3 domain binding|vesicle|membrane organization|regulation of clathrin-dependent endocytosis hsa04144 Endocytosis DNAJC7 2225.8152507612 2333.24303161118 2118.38746991121 0.907915481246886 -0.139370093033418 0.324761674406848 1 28.6275 27.0642 26.595 23.8671 GeneID:7266,Genbank:NM_003315.3,HGNC:HGNC:12392,MIM:601964 DnaJ heat shock protein family (Hsp40) member C7 GO:0001671,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006457,GO:0016020,GO:0031072,GO:0051085,GO:0070062,GO:1900034 ATPase activator activity|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein folding|membrane|heat shock protein binding|chaperone cofactor-dependent protein refolding|extracellular exosome|regulation of cellular response to heat DNAJC8 4575.49673136649 4686.31248436644 4464.68097836654 0.952706630908787 -0.0698960646884564 0.599879935959793 1 78.5028 81.8569 74.8883 78.2246 GeneID:22826,Genbank:NM_014280.2,HGNC:HGNC:15470 DnaJ heat shock protein family (Hsp40) member C8 GO:0000398,GO:0005634,GO:0005654,GO:0005829,GO:0030544,GO:0045171 mRNA splicing, via spliceosome|nucleus|nucleoplasm|cytosol|Hsp70 protein binding|intercellular bridge DNAJC9 2811.59218836039 2929.18911234811 2693.99526437267 0.919706840714389 -0.12075402376878 0.377575724820054 1 43.5919 46.0514 42.1153 41.8212 GeneID:23234,Genbank:NM_015190.4,HGNC:HGNC:19123,MIM:611206 DnaJ heat shock protein family (Hsp40) member C9 GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0031072,GO:0032781,GO:0035176 extracellular space|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|heat shock protein binding|positive regulation of ATPase activity|social behavior DNAL1 245.309400255788 285.581063822175 205.037736689402 0.717966849570512 -0.47801086234925 0.0863451629438743 0.964561165794104 1.43489 1.31213 1.23556 0.773875 GeneID:83544,Genbank:NM_001201366.1,HGNC:HGNC:23247,MIM:610062 dynein axonemal light chain 1 GO:0003774,GO:0005874,GO:0036157,GO:0036158,GO:0043014,GO:0045504 motor activity|microtubule|outer dynein arm|outer dynein arm assembly|alpha-tubulin binding|dynein heavy chain binding hsa05016 Huntington disease DNAL4 177.335053340125 185.060625492832 169.609481187417 0.916507661939071 -0.125781153243537 0.626867621878468 1 5.22897 4.19409 4.23337 4.37606 GeneID:10126,Genbank:NM_005740.2,HGNC:HGNC:2955,MIM:610565 dynein axonemal light chain 4 GO:0003777,GO:0005737,GO:0005874,GO:0005886,GO:0005929,GO:0007018,GO:0008092,GO:0030286,GO:0045505,GO:0051959,GO:2000582 microtubule motor activity|cytoplasm|microtubule|plasma membrane|cilium|microtubule-based movement|cytoskeletal protein binding|dynein complex|dynein intermediate chain binding|dynein light intermediate chain binding|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed hsa05016 Huntington disease DNALI1 2.07741475883001 3.67063118712625 0.484198330533773 0.131911463137993 -2.92235815430287 0.305991428012652 1 0.0472143 0.0289312 0 0.0138229 GeneID:7802,Genbank:NM_003462.3,HGNC:HGNC:14353,MIM:602135 dynein axonemal light intermediate chain 1 GO:0003774,GO:0005737,GO:0005930,GO:0030175,GO:0030286,GO:0045504 motor activity|cytoplasm|axoneme|filopodium|dynein complex|dynein heavy chain binding hsa05016 Huntington disease DNASE1 219.881337147774 213.436740531674 226.325933763874 1.06038882153135 0.0845933667113441 0.720946714928246 1 0.576235 0.644924 0.812073 0.683457 GeneID:1773,Genbank:XM_017023005.1,HGNC:HGNC:2956,MIM:125505 deoxyribonuclease 1 DNASE1L1 942.024683074121 861.040198226264 1023.00916792198 1.18810848788404 0.24866657669952 0.11094673475117 1 5.48961 5.96432 6.82711 7.3639 GeneID:1774,Genbank:NM_001009934.2,HGNC:HGNC:2957,MIM:300081 deoxyribonuclease 1 like 1 GO:0003677,GO:0004519,GO:0004536,GO:0005576,GO:0005634,GO:0005783,GO:0006259,GO:0006308,GO:0035580,GO:0043312,GO:0070062 DNA binding|endonuclease activity|deoxyribonuclease activity|extracellular region|nucleus|endoplasmic reticulum|DNA metabolic process|DNA catabolic process|specific granule lumen|neutrophil degranulation|extracellular exosome DNASE1L2 11.2591867465764 12.338028943196 10.1803445499568 0.825119198279309 -0.277325546020398 0.793845546137853 1 0.191488 0.115111 0.326295 0.0939236 GeneID:1775,Genbank:XM_011522399.2,HGNC:HGNC:2958,MIM:602622 deoxyribonuclease 1 like 2 GO:0001942,GO:0003335,GO:0003677,GO:0004519,GO:0004536,GO:0005509,GO:0005576,GO:0005634,GO:0005737,GO:0006259,GO:0006308 hair follicle development|corneocyte development|DNA binding|endonuclease activity|deoxyribonuclease activity|calcium ion binding|extracellular region|nucleus|cytoplasm|DNA metabolic process|DNA catabolic process DNASE2 2819.1997105744 2792.84746940291 2845.5519517459 1.01887123551157 0.0269717358736594 0.856069606816489 1 50.3261 51.7869 50.693 55.7619 GeneID:1777,Genbank:NM_001375.2,HGNC:HGNC:2960,MIM:126350 deoxyribonuclease 2, lysosomal GO:0003677,GO:0004531,GO:0005622,GO:0005764,GO:0006259,GO:0006309,GO:0030218,GO:0070062 DNA binding|deoxyribonuclease II activity|intracellular|lysosome|DNA metabolic process|apoptotic DNA fragmentation|erythrocyte differentiation|extracellular exosome hsa04142 Lysosome DND1 74.9145115335613 84.8959883964999 64.9330346706226 0.764853980701162 -0.386743747638734 0.260344301567853 1 1.29017 1.01723 1.19007 0.8028 GeneID:373863,Genbank:NM_194249.2,HGNC:HGNC:23799,MIM:609385 DND microRNA-mediated repression inhibitor 1 GO:0005634,GO:0005737,GO:0007275,GO:0007281,GO:0017091,GO:0060965 nucleus|cytoplasm|multicellular organism development|germ cell development|AU-rich element binding|negative regulation of gene silencing by miRNA DNER 1779.44147037289 1784.66342307731 1774.21951766847 0.994147969149933 -0.00846749614683828 0.94787202913047 1 22.8688 23.744 23.5559 23.0532 GeneID:92737,Genbank:NM_139072.3,HGNC:HGNC:24456,MIM:607299 delta/notch like EGF repeat containing GO:0001764,GO:0004888,GO:0005112,GO:0005509,GO:0005769,GO:0005886,GO:0006897,GO:0007219,GO:0007220,GO:0007416,GO:0007417,GO:0010001,GO:0016021,GO:0030276,GO:0030425,GO:0043025,GO:0048741 neuron migration|transmembrane signaling receptor activity|Notch binding|calcium ion binding|early endosome|plasma membrane|endocytosis|Notch signaling pathway|Notch receptor processing|synapse assembly|central nervous system development|glial cell differentiation|integral component of membrane|clathrin binding|dendrite|neuronal cell body|skeletal muscle fiber development DNHD1 61.1331417865849 60.2297391652158 62.0365444079539 1.02999855665624 0.0426423157518448 0.948142402643359 1 0.0876681 0.136524 0.132703 0.103953 GeneID:144132,Genbank:NM_144666.2,HGNC:HGNC:26532,MIM:617277 dynein heavy chain domain 1 GO:0003341,GO:0005524,GO:0008569,GO:0036156,GO:0036159,GO:0045503,GO:0045505,GO:0051959,GO:0070062 cilium movement|ATP binding|ATP-dependent microtubule motor activity, minus-end-directed|inner dynein arm|inner dynein arm assembly|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding|extracellular exosome DNLZ 178.348700911597 185.138077732841 171.559324090353 0.926656073084642 -0.109894110645335 0.638434787631521 1 14.5328 16.4657 15.0675 14.0601 GeneID:728489,Genbank:NM_001080849.2,HGNC:HGNC:33879 DNL-type zinc finger GO:0005654,GO:0005739,GO:0006457,GO:0008270,GO:0030150,GO:0050821,GO:0051087 nucleoplasm|mitochondrion|protein folding|zinc ion binding|protein import into mitochondrial matrix|protein stabilization|chaperone binding DNM1 564.253236140822 493.636827587426 634.869644694218 1.28610672707919 0.363010369134705 0.0322590427500118 0.712140594139387 3.61993 3.40505 4.91237 4.43284 GeneID:1759,Genbank:NM_001005336.2,HGNC:HGNC:2972,MIM:602377 dynamin 1 GO:0000266,GO:0001917,GO:0002031,GO:0003374,GO:0003924,GO:0005525,GO:0005634,GO:0005654,GO:0005794,GO:0005874,GO:0005886,GO:0006897,GO:0006898,GO:0007032,GO:0007605,GO:0008017,GO:0008021,GO:0008022,GO:0008344,GO:0016185,GO:0019901,GO:0030117,GO:0031749,GO:0031966,GO:0032403,GO:0042802,GO:0043196,GO:0043209,GO:0046983,GO:0050998,GO:0051262,GO:0051932,GO:0061025,GO:0072583,GO:1901998,GO:1903423 mitochondrial fission|photoreceptor inner segment|G-protein coupled receptor internalization|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|GTP binding|nucleus|nucleoplasm|Golgi apparatus|microtubule|plasma membrane|endocytosis|receptor-mediated endocytosis|endosome organization|sensory perception of sound|microtubule binding|synaptic vesicle|protein C-terminus binding|adult locomotory behavior|synaptic vesicle budding from presynaptic endocytic zone membrane|protein kinase binding|membrane coat|D2 dopamine receptor binding|mitochondrial membrane|protein complex binding|identical protein binding|varicosity|myelin sheath|protein dimerization activity|nitric-oxide synthase binding|protein tetramerization|synaptic transmission, GABAergic|membrane fusion|clathrin-dependent endocytosis|toxin transport|positive regulation of synaptic vesicle recycling hsa04072,hsa04144,hsa04721,hsa04961,hsa05100 Phospholipase D signaling pathway|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Bacterial invasion of epithelial cells DNM1L 566.37440563219 605.426874160078 527.321937104303 0.870991955611267 -0.199268700579097 0.513330071631928 1 4.68019 3.57688 4.22427 3.35 GeneID:10059,Genbank:NM_001278464.1,HGNC:HGNC:2973,MIM:603850 dynamin 1 like GO:0000139,GO:0000266,GO:0001836,GO:0003374,GO:0003924,GO:0005096,GO:0005525,GO:0005737,GO:0005739,GO:0005741,GO:0005777,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005874,GO:0005903,GO:0005905,GO:0006897,GO:0007005,GO:0008017,GO:0008289,GO:0010637,GO:0010821,GO:0015630,GO:0016020,GO:0016559,GO:0017137,GO:0030054,GO:0030276,GO:0030672,GO:0030742,GO:0031625,GO:0032403,GO:0032459,GO:0036466,GO:0042802,GO:0042803,GO:0043065,GO:0043231,GO:0043234,GO:0043653,GO:0048312,GO:0048471,GO:0050714,GO:0051259,GO:0051289,GO:0051433,GO:0060047,GO:0061003,GO:0061025,GO:0070266,GO:0070584,GO:0070585,GO:0090141,GO:0090149,GO:0090200,GO:0090650,GO:0097194,GO:1900063,GO:1900244,GO:1903146,GO:1903578,GO:1904579,GO:1905395,GO:1990910,GO:2000302,GO:2001244 Golgi membrane|mitochondrial fission|release of cytochrome c from mitochondria|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|GTPase activator activity|GTP binding|cytoplasm|mitochondrion|mitochondrial outer membrane|peroxisome|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|microtubule|brush border|clathrin-coated pit|endocytosis|mitochondrion organization|microtubule binding|lipid binding|negative regulation of mitochondrial fusion|regulation of mitochondrion organization|microtubule cytoskeleton|membrane|peroxisome fission|Rab GTPase binding|cell junction|clathrin binding|synaptic vesicle membrane|GTP-dependent protein binding|ubiquitin protein ligase binding|protein complex binding|regulation of protein oligomerization|synaptic vesicle recycling via endosome|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|intracellular membrane-bounded organelle|protein complex|mitochondrial fragmentation involved in apoptotic process|intracellular distribution of mitochondria|perinuclear region of cytoplasm|positive regulation of protein secretion|protein oligomerization|protein homotetramerization|BH2 domain binding|heart contraction|positive regulation of dendritic spine morphogenesis|membrane fusion|necroptotic process|mitochondrion morphogenesis|protein localization to mitochondrion|positive regulation of mitochondrial fission|mitochondrial membrane fission|positive regulation of release of cytochrome c from mitochondria|cellular response to oxygen-glucose deprivation|execution phase of apoptosis|regulation of peroxisome organization|positive regulation of synaptic vesicle endocytosis|regulation of autophagy of mitochondrion|regulation of ATP metabolic process|cellular response to thapsigargin|response to flavonoid|response to hypobaric hypoxia|positive regulation of synaptic vesicle exocytosis|positive regulation of intrinsic apoptotic signaling pathway hsa04217,hsa04621,hsa04668 Necroptosis|NOD-like receptor signaling pathway|TNF signaling pathway DNM2 4976.1433708015 4914.67696602431 5037.60977557868 1.02501340584625 0.035642778434548 0.812302067093366 1 37.9173 41.1713 41.2217 41.1561 GeneID:1785,Genbank:NM_001005360.2,HGNC:HGNC:2974,MIM:602378 dynamin 2 hsa04072,hsa04144,hsa04666,hsa04721,hsa04961,hsa05100 Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Bacterial invasion of epithelial cells DNM3 221.105491063588 210.034649682442 232.176332444735 1.10541919057532 0.144593563718195 0.614564677239792 1 0.22592 0.185006 0.287496 0.181809 GeneID:26052,Genbank:NM_001350206.1,HGNC:HGNC:29125,MIM:611445 dynamin 3 GO:0000266,GO:0001917,GO:0003374,GO:0003924,GO:0005525,GO:0005794,GO:0005874,GO:0006897,GO:0007416,GO:0008017,GO:0014069,GO:0016185,GO:0030424,GO:0031798,GO:0031802,GO:0031966,GO:0042802,GO:0043083,GO:0043197,GO:0044327,GO:0046847,GO:0048471,GO:0050998,GO:0051491,GO:0061002,GO:0061025,GO:0061828,GO:0061829,GO:0070062,GO:0098844,GO:0098884,GO:1903423 mitochondrial fission|photoreceptor inner segment|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|GTP binding|Golgi apparatus|microtubule|endocytosis|synapse assembly|microtubule binding|postsynaptic density|synaptic vesicle budding from presynaptic endocytic zone membrane|axon|type 1 metabotropic glutamate receptor binding|type 5 metabotropic glutamate receptor binding|mitochondrial membrane|identical protein binding|synaptic cleft|dendritic spine|dendritic spine head|filopodium assembly|perinuclear region of cytoplasm|nitric-oxide synthase binding|positive regulation of filopodium assembly|negative regulation of dendritic spine morphogenesis|membrane fusion|apical tubulobulbar complex|basal tubulobulbar complex|extracellular exosome|postsynaptic endocytic zone membrane|postsynaptic neurotransmitter receptor internalization|positive regulation of synaptic vesicle recycling hsa04072,hsa04144,hsa04721,hsa04961,hsa05100 Phospholipase D signaling pathway|Endocytosis|Synaptic vesicle cycle|Endocrine and other factor-regulated calcium reabsorption|Bacterial invasion of epithelial cells DNMBP 1621.28197146232 1562.14666562761 1680.41727729704 1.07571031214403 0.105289613672955 0.606772326339338 1 5.66084 6.11577 7.404 5.40017 GeneID:23268,Genbank:NM_015221.3,HGNC:HGNC:30373,MIM:611282 dynamin binding protein GO:0005089,GO:0005795,GO:0005856,GO:0007264,GO:0030054,GO:0035023,GO:0043547,GO:0045202 Rho guanyl-nucleotide exchange factor activity|Golgi stack|cytoskeleton|small GTPase mediated signal transduction|cell junction|regulation of Rho protein signal transduction|positive regulation of GTPase activity|synapse DNMT1 8940.75658699696 9008.76202711563 8872.75114687829 0.984902378392507 -0.0219473603575238 0.856632455383542 1 39.6254 40.4368 42.2574 38.5875 GeneID:1786,Genbank:NM_001379.3,HGNC:HGNC:2976,MIM:126375 DNA methyltransferase 1 hsa00270,hsa05206 Cysteine and methionine metabolism|MicroRNAs in cancer DNMT3A 314.748088118818 299.956830613209 329.539345624426 1.09862257495767 0.135695842376712 0.505293726933164 1 1.33132 1.23846 1.44213 1.46283 GeneID:1788,Genbank:NM_175629.2,HGNC:HGNC:2978,MIM:602769 DNA methyltransferase 3 alpha GO:0000122,GO:0000278,GO:0000775,GO:0000791,GO:0001741,GO:0003677,GO:0003682,GO:0003886,GO:0005634,GO:0005654,GO:0005720,GO:0005737,GO:0006306,GO:0006346,GO:0006349,GO:0007283,GO:0007568,GO:0009008,GO:0010212,GO:0010288,GO:0010942,GO:0016363,GO:0030182,GO:0032355,GO:0033189,GO:0042220,GO:0042802,GO:0043045,GO:0043046,GO:0045814,GO:0046872,GO:0071230,GO:0071361,GO:0071456,GO:0097284 negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|chromosome, centromeric region|euchromatin|XY body|DNA binding|chromatin binding|DNA (cytosine-5-)-methyltransferase activity|nucleus|nucleoplasm|nuclear heterochromatin|cytoplasm|DNA methylation|methylation-dependent chromatin silencing|regulation of gene expression by genetic imprinting|spermatogenesis|aging|DNA-methyltransferase activity|response to ionizing radiation|response to lead ion|positive regulation of cell death|nuclear matrix|neuron differentiation|response to estradiol|response to vitamin A|response to cocaine|identical protein binding|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|negative regulation of gene expression, epigenetic|metal ion binding|cellular response to amino acid stimulus|cellular response to ethanol|cellular response to hypoxia|hepatocyte apoptotic process hsa00270,hsa05206 Cysteine and methionine metabolism|MicroRNAs in cancer DNMT3B 171.581261878538 169.657706624053 173.504817133023 1.02267571916137 0.0323487525871792 0.909915094972019 1 1.05115 1.03739 1.13731 1.08565 GeneID:1789,Genbank:NM_006892.3,HGNC:HGNC:2979,MIM:602900 DNA methyltransferase 3 beta hsa00270,hsa05206 Cysteine and methionine metabolism|MicroRNAs in cancer DNPEP 724.884616335057 721.371882670125 728.397349999988 1.00973903682503 0.0139824821598111 0.93921950324964 1 5.44079 5.55875 5.78191 5.56886 GeneID:23549,Genbank:NM_001319117.1,HGNC:HGNC:2981,MIM:611367 aspartyl aminopeptidase GO:0004177,GO:0005634,GO:0005737,GO:0005829,GO:0006518,GO:0008270,GO:0042802,GO:0070006,GO:0072562 aminopeptidase activity|nucleus|cytoplasm|cytosol|peptide metabolic process|zinc ion binding|identical protein binding|metalloaminopeptidase activity|blood microparticle DNPH1 359.347866660287 367.39356198373 351.302171336844 0.956201217680568 -0.0646138519913398 0.809426251456799 1 19.8232 23.412 18.0444 23.4397 GeneID:10591,Genbank:NM_006443.2,HGNC:HGNC:21218 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 GO:0005634,GO:0005829,GO:0006195,GO:0008283,GO:0009159,GO:0030307,GO:0030855,GO:0042802,GO:0042803,GO:0050144,GO:0070062,GO:0070694 nucleus|cytosol|purine nucleotide catabolic process|cell proliferation|deoxyribonucleoside monophosphate catabolic process|positive regulation of cell growth|epithelial cell differentiation|identical protein binding|protein homodimerization activity|nucleoside deoxyribosyltransferase activity|extracellular exosome|deoxyribonucleoside 5'-monophosphate N-glycosidase activity DNTTIP1 794.11162795548 827.388967625477 760.834288285484 0.919560591276679 -0.120983455699442 0.440326395774442 1 18.3011 19.2502 17.5481 18.5314 GeneID:116092,Genbank:NM_052951.2,HGNC:HGNC:16160,MIM:611388 deoxynucleotidyltransferase terminal interacting protein 1 GO:0000118,GO:0003677,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0006355,GO:0031491,GO:0042803 histone deacetylase complex|DNA binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|nucleosome binding|protein homodimerization activity DNTTIP2 280.139983899537 329.080731735939 231.199236063134 0.702560842269709 -0.509304925724749 0.107599864126957 1 3.50564 2.73281 2.63176 1.80651 GeneID:30836,Genbank:NM_014597.4,HGNC:HGNC:24013,MIM:611199 deoxynucleotidyltransferase terminal interacting protein 2 GO:0003723,GO:0005634,GO:0005730,GO:0006351,GO:0006355 RNA binding|nucleus|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated DOC2A 33.3805171943989 35.2655236307142 31.4955107580836 0.893096359149275 -0.163112253956277 0.79888050527492 1 0.0817505 0.27388 0.0864849 0.182041 GeneID:8448,Genbank:XM_011545975.1,HGNC:HGNC:2985,MIM:604567 double C2 domain alpha GO:0005509,GO:0005544,GO:0005634,GO:0005730,GO:0005764,GO:0005886,GO:0006906,GO:0007268,GO:0007399,GO:0017158,GO:0019905,GO:0030054,GO:0030276,GO:0030672,GO:0043005,GO:0048791,GO:0070382 calcium ion binding|calcium-dependent phospholipid binding|nucleus|nucleolus|lysosome|plasma membrane|vesicle fusion|chemical synaptic transmission|nervous system development|regulation of calcium ion-dependent exocytosis|syntaxin binding|cell junction|clathrin binding|synaptic vesicle membrane|neuron projection|calcium ion-regulated exocytosis of neurotransmitter|exocytic vesicle DOC2B 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0145711 0 0 0 GeneID:8447,Genbank:NM_003585.4,HGNC:HGNC:2986,MIM:604568 double C2 domain beta GO:0005509,GO:0005544,GO:0005737,GO:0005886,GO:0006906,GO:0008104,GO:0017158,GO:0019905,GO:0030276,GO:0031340,GO:0032024,GO:0045956,GO:0048791,GO:0070382,GO:0098793 calcium ion binding|calcium-dependent phospholipid binding|cytoplasm|plasma membrane|vesicle fusion|protein localization|regulation of calcium ion-dependent exocytosis|syntaxin binding|clathrin binding|positive regulation of vesicle fusion|positive regulation of insulin secretion|positive regulation of calcium ion-dependent exocytosis|calcium ion-regulated exocytosis of neurotransmitter|exocytic vesicle|presynapse DOCK1 1588.73003353817 1529.05990766623 1648.40015941012 1.07804812038139 0.108421576500598 0.550397476330091 1 4.37304 3.81251 5.23626 3.89214 GeneID:1793,Genbank:NM_001290223.1,HGNC:HGNC:2987,MIM:601403 dedicator of cytokinesis 1 GO:0005089,GO:0005096,GO:0005634,GO:0005737,GO:0005829,GO:0006911,GO:0006915,GO:0007010,GO:0007165,GO:0007229,GO:0007264,GO:0007596,GO:0010634,GO:0016020,GO:0016477,GO:0016607,GO:0017124,GO:0032045,GO:0038096,GO:0048010,GO:1900026 Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|nucleus|cytoplasm|cytosol|phagocytosis, engulfment|apoptotic process|cytoskeleton organization|signal transduction|integrin-mediated signaling pathway|small GTPase mediated signal transduction|blood coagulation|positive regulation of epithelial cell migration|membrane|cell migration|nuclear speck|SH3 domain binding|guanyl-nucleotide exchange factor complex|Fc-gamma receptor signaling pathway involved in phagocytosis|vascular endothelial growth factor receptor signaling pathway|positive regulation of substrate adhesion-dependent cell spreading hsa04510,hsa04810,hsa05100,hsa05131 Focal adhesion|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis DOCK10 223.706923601032 225.409159586752 222.004687615312 0.984896479017619 -0.0219560018478594 0.965083016817862 1 0.65178 0.60989 0.78917 0.437278 GeneID:55619,Genbank:NM_014689.2,HGNC:HGNC:23479,MIM:611518 dedicator of cytokinesis 10 GO:0001782,GO:0002315,GO:0005085,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007264,GO:0016020,GO:0030334,GO:0043197,GO:0043547,GO:0060997,GO:0070062 B cell homeostasis|marginal zone B cell differentiation|guanyl-nucleotide exchange factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|small GTPase mediated signal transduction|membrane|regulation of cell migration|dendritic spine|positive regulation of GTPase activity|dendritic spine morphogenesis|extracellular exosome DOCK11 65.9712963545871 58.7399076491279 73.2026850600462 1.24621723100603 0.31755556978966 0.632300254975589 1 0.276928 0.180877 0.438554 0.205817 GeneID:139818,Genbank:XM_005262368.4,HGNC:HGNC:23483,MIM:300681 dedicator of cytokinesis 11 GO:0001782,GO:0002315,GO:0005085,GO:0005089,GO:0005829,GO:0007264,GO:0007596,GO:0043547,GO:0051491 B cell homeostasis|marginal zone B cell differentiation|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytosol|small GTPase mediated signal transduction|blood coagulation|positive regulation of GTPase activity|positive regulation of filopodium assembly DOCK2 196.765359501563 226.80293855347 166.727780449657 0.735121782429418 -0.443944824049763 0.0512979269145925 0.82808973186751 0.449343 0.446542 0.379837 0.309426 GeneID:1794,Genbank:NM_004946.2,HGNC:HGNC:2988,MIM:603122 dedicator of cytokinesis 2 GO:0001766,GO:0001768,GO:0001771,GO:0002277,GO:0005096,GO:0005576,GO:0005829,GO:0005856,GO:0006935,GO:0007264,GO:0016020,GO:0030036,GO:0030676,GO:0035580,GO:0042608,GO:0043312,GO:0044351,GO:0045059,GO:0045060,GO:0046633,GO:0050690,GO:0050766,GO:0070062 membrane raft polarization|establishment of T cell polarity|immunological synapse formation|myeloid dendritic cell activation involved in immune response|GTPase activator activity|extracellular region|cytosol|cytoskeleton|chemotaxis|small GTPase mediated signal transduction|membrane|actin cytoskeleton organization|Rac guanyl-nucleotide exchange factor activity|specific granule lumen|T cell receptor binding|neutrophil degranulation|macropinocytosis|positive thymic T cell selection|negative thymic T cell selection|alpha-beta T cell proliferation|regulation of defense response to virus by virus|positive regulation of phagocytosis|extracellular exosome hsa04062,hsa04666 Chemokine signaling pathway|Fc gamma R-mediated phagocytosis DOCK3 427.405416707383 431.658525223336 423.15230819143 0.980294106255622 -0.0287134456795498 0.912507305378884 1 0.833008 0.89881 1.0448 0.646282 GeneID:1795,Genbank:XM_005264914.3,HGNC:HGNC:2989,MIM:603123 dedicator of cytokinesis 3 GO:0005085,GO:0005829,GO:0007264,GO:0017124 guanyl-nucleotide exchange factor activity|cytosol|small GTPase mediated signal transduction|SH3 domain binding DOCK4 1259.70702493875 1158.34272407413 1361.07132580337 1.17501607902038 0.232680498887506 0.423805718318293 1 4.21022 3.90272 5.93022 3.82029 GeneID:9732,Genbank:NM_014705.3,HGNC:HGNC:19192,MIM:607679 dedicator of cytokinesis 4 GO:0005085,GO:0005096,GO:0005730,GO:0005794,GO:0005829,GO:0005886,GO:0007264,GO:0016020,GO:0017124,GO:0030165,GO:0030971,GO:0032420,GO:0032421,GO:0048365,GO:0060326,GO:1904694,GO:1904754 guanyl-nucleotide exchange factor activity|GTPase activator activity|nucleolus|Golgi apparatus|cytosol|plasma membrane|small GTPase mediated signal transduction|membrane|SH3 domain binding|PDZ domain binding|receptor tyrosine kinase binding|stereocilium|stereocilium bundle|Rac GTPase binding|cell chemotaxis|negative regulation of vascular smooth muscle contraction|positive regulation of vascular associated smooth muscle cell migration hsa04015 Rap1 signaling pathway DOCK5 1258.03452258567 1253.86639583453 1262.20264933682 1.00664843840618 0.00955992492942947 0.965568560152974 1 3.26808 3.0636 4.03365 2.55785 GeneID:80005,Genbank:NM_024940.7,HGNC:HGNC:23476,MIM:616904 dedicator of cytokinesis 5 GO:0005085,GO:0005737,GO:0005829,GO:0005886,GO:0007264,GO:0010634,GO:1900026,GO:1904694,GO:1904754 guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|plasma membrane|small GTPase mediated signal transduction|positive regulation of epithelial cell migration|positive regulation of substrate adhesion-dependent cell spreading|negative regulation of vascular smooth muscle contraction|positive regulation of vascular associated smooth muscle cell migration DOCK6 678.720504941701 697.887689996604 659.553319886799 0.945070860742664 -0.0815055892474554 0.609232813654826 1 3.41113 3.46073 3.11602 3.38281 GeneID:57572,Genbank:NM_020812.3,HGNC:HGNC:19189,MIM:614194 dedicator of cytokinesis 6 GO:0005085,GO:0005829,GO:0007264,GO:0007596,GO:0048471 guanyl-nucleotide exchange factor activity|cytosol|small GTPase mediated signal transduction|blood coagulation|perinuclear region of cytoplasm DOCK7 495.166098068432 510.452125732284 479.88007040458 0.940107889091762 -0.0891017613674484 0.794923092181384 1 1.90941 1.8018 2.2749 1.23208 GeneID:85440,Genbank:NM_001272001.1,HGNC:HGNC:19190,MIM:615730 dedicator of cytokinesis 7 GO:0000226,GO:0005085,GO:0005622,GO:0005925,GO:0007264,GO:0007409,GO:0022027,GO:0030424,GO:0030426,GO:0031175,GO:0033138,GO:0043005,GO:0045178,GO:0045200,GO:0048365,GO:0050767,GO:0090630,GO:1904754 microtubule cytoskeleton organization|guanyl-nucleotide exchange factor activity|intracellular|focal adhesion|small GTPase mediated signal transduction|axonogenesis|interkinetic nuclear migration|axon|growth cone|neuron projection development|positive regulation of peptidyl-serine phosphorylation|neuron projection|basal part of cell|establishment of neuroblast polarity|Rac GTPase binding|regulation of neurogenesis|activation of GTPase activity|positive regulation of vascular associated smooth muscle cell migration DOCK8 6.96907841733806 7.63922867747008 6.29892815720603 0.824550281598858 -0.278320622083956 0.856407557169082 1 0.0239318 0.0398805 0.0227337 0.0296486 GeneID:81704,Genbank:XM_011518045.3,HGNC:HGNC:19191,MIM:611432 dedicator of cytokinesis 8 GO:0001771,GO:0005085,GO:0005737,GO:0005829,GO:0007264,GO:0007596,GO:0016020,GO:0031256,GO:0031258,GO:0036336,GO:0043547,GO:0061485,GO:0070233,GO:1903905,GO:1990869,GO:2000406 immunological synapse formation|guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|small GTPase mediated signal transduction|blood coagulation|membrane|leading edge membrane|lamellipodium membrane|dendritic cell migration|positive regulation of GTPase activity|memory T cell proliferation|negative regulation of T cell apoptotic process|positive regulation of establishment of T cell polarity|cellular response to chemokine|positive regulation of T cell migration DOCK9 458.686930729358 457.391161152797 459.982700305919 1.00566591437095 0.00815111654532612 0.969552207397813 1 1.5594 1.41899 1.81501 1.16698 GeneID:23348,Genbank:NM_001318849.1,HGNC:HGNC:14132,MIM:607325 dedicator of cytokinesis 9 GO:0005085,GO:0005829,GO:0007264,GO:0007596,GO:0012505,GO:0016020,GO:0043547,GO:0045296 guanyl-nucleotide exchange factor activity|cytosol|small GTPase mediated signal transduction|blood coagulation|endomembrane system|membrane|positive regulation of GTPase activity|cadherin binding DOHH 562.124009918654 565.002921827859 559.245098009449 0.989809214083738 -0.0147776226450219 0.952045791177574 1 10.7505 9.27517 10.2232 10.3476 GeneID:83475,Genbank:NM_001145165.1,HGNC:HGNC:28662,MIM:611262 deoxyhypusine hydroxylase GO:0005829,GO:0008612,GO:0019135,GO:0046872 cytosol|peptidyl-lysine modification to peptidyl-hypusine|deoxyhypusine monooxygenase activity|metal ion binding DOK1 344.364188995547 336.423011111047 352.305366880048 1.04720948105348 0.0665500640907079 0.736378974328796 1 4.42143 4.06519 4.22776 4.70587 GeneID:1796,Genbank:NM_001197260.1,HGNC:HGNC:2990,MIM:602919 docking protein 1 GO:0005057,GO:0005634,GO:0005829,GO:0007165,GO:0007166,GO:0007169,GO:0007265,GO:0007411,GO:0045742,GO:0048471 signal transducer activity, downstream of receptor|nucleus|cytosol|signal transduction|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|Ras protein signal transduction|axon guidance|positive regulation of epidermal growth factor receptor signaling pathway|perinuclear region of cytoplasm hsa05162 Measles DOK2 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0763595 GeneID:9046,Genbank:XM_005273680.4,HGNC:HGNC:2991,MIM:604997 docking protein 2 GO:0005057,GO:0005068,GO:0005829,GO:0007165,GO:0007166,GO:0007265,GO:0007411,GO:0050900 signal transducer activity, downstream of receptor|transmembrane receptor protein tyrosine kinase adaptor activity|cytosol|signal transduction|cell surface receptor signaling pathway|Ras protein signal transduction|axon guidance|leukocyte migration DOK3 88.5046284159942 96.0715780921493 80.937678739839 0.842472668266214 -0.247298212149432 0.426443891911877 1 0.860843 0.937311 0.892847 0.723676 GeneID:79930,Genbank:XM_011534655.3,HGNC:HGNC:24583,MIM:611435 docking protein 3 GO:0005886,GO:0030667,GO:0043312,GO:0101003 plasma membrane|secretory granule membrane|neutrophil degranulation|ficolin-1-rich granule membrane DOK4 149.656950180385 143.281111813472 156.032788547297 1.08899761156534 0.123000789879776 0.686643221323577 1 1.35576 1.59764 1.51503 1.77894 GeneID:55715,Genbank:NM_001330556.1,HGNC:HGNC:19868,MIM:608333 docking protein 4 GO:0005829,GO:0007411 cytosol|axon guidance DOK5 1.97092102469304 1.51824048055703 2.42360156882906 1.59632258516771 0.674752221106181 0.891291031725468 1 0.018111 0.0334783 0.0515779 0.0320626 GeneID:55816,Genbank:NM_018431.4,HGNC:HGNC:16173,MIM:608334 docking protein 5 GO:0000165,GO:0005057,GO:0005829,GO:0007169,GO:0007411,GO:0051386 MAPK cascade|signal transducer activity, downstream of receptor|cytosol|transmembrane receptor protein tyrosine kinase signaling pathway|axon guidance|regulation of neurotrophin TRK receptor signaling pathway DOK6 45.4103055491908 41.3767031725193 49.4439079258623 1.19496973259824 0.256974076629934 0.577608728436722 1 0.10421 0.121361 0.169351 0.0909628 GeneID:220164,Genbank:XM_011525875.2,HGNC:HGNC:28301,MIM:611402 docking protein 6 GO:0005829,GO:0007411 cytosol|axon guidance DOK7 5.708140632255 3.18055978516888 8.23572147934112 2.58939370287731 1.37261433565378 0.282478494503308 1 0.0103614 0.0087686 0.0190338 0.0981431 GeneID:285489,Genbank:NM_001301071.1,HGNC:HGNC:26594,MIM:610285 docking protein 7 DOLK 530.425335670212 542.777220951254 518.073450389171 0.954486353501003 -0.067203523635486 0.713245561609437 1 14.0446 12.4769 13.4936 12.5044 GeneID:22845,Genbank:NM_014908.3,HGNC:HGNC:23406,MIM:610746 dolichol kinase GO:0004168,GO:0005789,GO:0006486,GO:0006489,GO:0030176,GO:0043048 dolichol kinase activity|endoplasmic reticulum membrane|protein glycosylation|dolichyl diphosphate biosynthetic process|integral component of endoplasmic reticulum membrane|dolichyl monophosphate biosynthetic process hsa00510 N-Glycan biosynthesis DOLPP1 811.383644596765 818.317742361711 804.44954683182 0.983052798672228 -0.0246591906948684 0.876876802782821 1 15.9974 15.9833 15.8018 16.2416 GeneID:57171,Genbank:NM_020438.4,HGNC:HGNC:29565,MIM:614516 dolichyldiphosphatase 1 GO:0005789,GO:0006487,GO:0006489,GO:0008610,GO:0030176,GO:0047874 endoplasmic reticulum membrane|protein N-linked glycosylation|dolichyl diphosphate biosynthetic process|lipid biosynthetic process|integral component of endoplasmic reticulum membrane|dolichyldiphosphatase activity hsa00510 N-Glycan biosynthesis DONSON 785.207761207871 778.007425887369 792.408096528373 1.01850968276373 0.0264596957763775 0.868746069864754 1 12.4671 12.4976 14.054 11.8284 GeneID:29980,Genbank:NM_017613.3,HGNC:HGNC:2993,MIM:611428 downstream neighbor of SON GO:0000077,GO:0005634,GO:0005657,GO:0006260,GO:0007095,GO:0007275,GO:0030894,GO:0033260,GO:0048478 DNA damage checkpoint|nucleus|replication fork|DNA replication|mitotic G2 DNA damage checkpoint|multicellular organism development|replisome|nuclear DNA replication|replication fork protection DOPEY1 139.261946957044 144.750309018489 133.773584895598 0.92416787088524 -0.113773160457851 0.819594798982698 1 0.531296 0.331537 0.496653 0.338676 GeneID:23033,Genbank:NM_015018.3,HGNC:HGNC:21194,MIM:616823 dopey family member 1 GO:0005768,GO:0005802,GO:0005829,GO:0006895,GO:0015031 endosome|trans-Golgi network|cytosol|Golgi to endosome transport|protein transport DOPEY2 387.65250633664 418.600102159866 356.704910513415 0.852137657570822 -0.230841587144265 0.208010774634576 1 1.90965 2.11064 1.84948 1.60567 GeneID:9980,Genbank:NM_001320714.1,HGNC:HGNC:1291,MIM:604803 dopey family member 2 GO:0000139,GO:0005768,GO:0005802,GO:0005829,GO:0006895,GO:0007029,GO:0007275,GO:0015031,GO:0050890,GO:0070062 Golgi membrane|endosome|trans-Golgi network|cytosol|Golgi to endosome transport|endoplasmic reticulum organization|multicellular organism development|protein transport|cognition|extracellular exosome DOT1L 1941.12386347241 1850.13107718574 2032.11664975907 1.09836361045843 0.135355733910814 0.34977531758291 1 8.08452 8.21845 9.72369 8.52398 GeneID:84444,Genbank:XM_005259659.3,HGNC:HGNC:24948,MIM:607375 DOT1 like histone lysine methyltransferase GO:0000077,GO:0000781,GO:0003677,GO:0005634,GO:0005654,GO:0006281,GO:0006348,GO:0008134,GO:0008284,GO:0018024,GO:0031151,GO:0032200,GO:0034729,GO:0042054,GO:0043231,GO:0043234,GO:0045944,GO:0046425,GO:2000677 DNA damage checkpoint|chromosome, telomeric region|DNA binding|nucleus|nucleoplasm|DNA repair|chromatin silencing at telomere|transcription factor binding|positive regulation of cell proliferation|histone-lysine N-methyltransferase activity|histone methyltransferase activity (H3-K79 specific)|telomere organization|histone H3-K79 methylation|histone methyltransferase activity|intracellular membrane-bounded organelle|protein complex|positive regulation of transcription from RNA polymerase II promoter|regulation of JAK-STAT cascade|regulation of transcription regulatory region DNA binding hsa00310,hsa05202 Lysine degradation|Transcriptional misregulation in cancer DPAGT1 1325.39717037692 1271.49138299649 1379.30295775734 1.08479143170187 0.117417688408018 0.432895764025547 1 26.1984 27.2542 31.9667 28.331 GeneID:1798,Genbank:NM_001382.3,HGNC:HGNC:2995,MIM:191350 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 hsa00510 N-Glycan biosynthesis DPCD 482.742887795017 462.993668983283 502.49210660675 1.08531096701647 0.118108467826267 0.630706434908551 1 2.22509 2.00729 2.24919 2.64632 GeneID:25911,Genbank:NM_001329742.1,HGNC:HGNC:24542,MIM:616467 deleted in primary ciliary dyskinesia homolog (mouse) GO:0003351,GO:0005634,GO:0007283,GO:0007368,GO:0021670,GO:0021678,GO:0030317,GO:0060972 epithelial cilium movement|nucleus|spermatogenesis|determination of left/right symmetry|lateral ventricle development|third ventricle development|flagellated sperm motility|left/right pattern formation DPEP1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0130411 0 0 0 GeneID:1800,Genbank:NM_001128141.2,HGNC:HGNC:3002,MIM:179780 dipeptidase 1 GO:0005615,GO:0005634,GO:0005886,GO:0006691,GO:0006749,GO:0006805,GO:0008235,GO:0008239,GO:0008270,GO:0016324,GO:0016805,GO:0016999,GO:0030054,GO:0030336,GO:0031225,GO:0031528,GO:0034235,GO:0035690,GO:0043027,GO:0043066,GO:0043154,GO:0045177,GO:0050667,GO:0070062,GO:0070573,GO:0071277,GO:0071732,GO:0072340,GO:0072341 extracellular space|nucleus|plasma membrane|leukotriene metabolic process|glutathione metabolic process|xenobiotic metabolic process|metalloexopeptidase activity|dipeptidyl-peptidase activity|zinc ion binding|apical plasma membrane|dipeptidase activity|antibiotic metabolic process|cell junction|negative regulation of cell migration|anchored component of membrane|microvillus membrane|GPI anchor binding|cellular response to drug|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|apical part of cell|homocysteine metabolic process|extracellular exosome|metallodipeptidase activity|cellular response to calcium ion|cellular response to nitric oxide|cellular lactam catabolic process|modified amino acid binding DPF1 181.111975886093 184.350040027666 177.873911744521 0.964870480732343 -0.0515927994972521 0.829464311930842 1 1.71302 1.89905 2.26149 1.90021 GeneID:8193,Genbank:NM_001135156.2,HGNC:HGNC:20225,MIM:601670 double PHD fingers 1 GO:0003676,GO:0005737,GO:0006351,GO:0006355,GO:0007399,GO:0046872,GO:0071565 nucleic acid binding|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|nervous system development|metal ion binding|nBAF complex hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma DPF2 974.61823386134 997.412284137648 951.824183585033 0.954293624334064 -0.0674948609478548 0.645519006594876 1 7.22527 7.9402 7.78419 7.04746 GeneID:5977,Genbank:NM_001330308.1,HGNC:HGNC:9964,MIM:601671 double PHD fingers 2 GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0006915,GO:0046872 nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|metal ion binding DPF3 109.646475027154 101.538798752834 117.754151301474 1.1596961235292 0.213746823878874 0.447924655360563 1 0.300249 0.223897 0.284034 0.326336 GeneID:8110,Genbank:XM_017021670.2,HGNC:HGNC:17427,MIM:601672 double PHD fingers 3 GO:0003676,GO:0005654,GO:0006351,GO:0006355,GO:0007399,GO:0016569,GO:0046872,GO:0071565 nucleic acid binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|nervous system development|covalent chromatin modification|metal ion binding|nBAF complex hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma DPH1 474.545360115327 495.952914428266 453.137805802388 0.913671021219353 -0.130253296661887 0.4571787867617 1 14.2439 14.4885 14.3552 13.2726 GeneID:1801,Genbank:NM_001383.4,HGNC:HGNC:3003,MIM:603527 diphthamide biosynthesis 1 GO:0005654,GO:0005829,GO:0008283,GO:0016740,GO:0017183,GO:0030054 nucleoplasm|cytosol|cell proliferation|transferase activity|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|cell junction DPH2 1432.92956113719 1508.40250754657 1357.4566147278 0.899929964274398 -0.152115364695674 0.293888730447035 1 20.0222 19.7245 19.5476 18.11 GeneID:1802,Genbank:NM_001319170.1,HGNC:HGNC:3004,MIM:603456 DPH2 homolog GO:0005829,GO:0017183,GO:0090560 cytosol|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|2-(3-amino-3-carboxypropyl)histidine synthase activity DPH3 540.665506679093 541.421659604113 539.909353754074 0.997206787310384 -0.0040353925776957 0.990175344846211 1 5.52966 4.56375 5.58951 4.67003 GeneID:285381,Genbank:NM_001047434.2,HGNC:HGNC:27717,MIM:608959 diphthamide biosynthesis 3 GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0017183,GO:0046872,GO:0050709,GO:0051099 nucleus|nucleoplasm|cytoplasm|cytosol|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|metal ion binding|negative regulation of protein secretion|positive regulation of binding DPH3P1 6.49627710924618 5.72696934432558 7.26558487416678 1.26866138743447 0.343307057471479 0.814742019223476 1 0.196294 0.0515574 0.053043 0.248568 GeneID:100132911,Genbank:NM_080750.4,HGNC:HGNC:16136 diphthamide biosynthesis 3 pseudogene 1 GO:0046872 metal ion binding DPH5 548.583784464422 537.453062113769 559.714506815075 1.04142025838266 0.0585523763538933 0.740775341854028 1 1.0384 0.901784 0.979472 1.03323 GeneID:51611,Genbank:XM_005270938.2,HGNC:HGNC:24270,MIM:611075 diphthamide biosynthesis 5 GO:0004164,GO:0005829,GO:0017183 diphthine synthase activity|cytosol|peptidyl-diphthamide biosynthetic process from peptidyl-histidine DPH6 147.454145118866 148.546418720309 146.361871517423 0.98529384133454 -0.0213740553770963 0.957017996231292 1 0.479091 0.485193 0.520837 0.519715 GeneID:89978,Genbank:XM_017022708.2,HGNC:HGNC:30543 diphthamine biosynthesis 6 GO:0005524,GO:0005634,GO:0005730,GO:0005829,GO:0017178,GO:0017183,GO:0031647,GO:1903955 ATP binding|nucleus|nucleolus|cytosol|diphthine-ammonia ligase activity|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|regulation of protein stability|positive regulation of protein targeting to mitochondrion DPH7 723.279957881047 766.678965713411 679.880950048684 0.886787013148378 -0.173340452561737 0.277145304358941 1 3.49888 3.78942 3.10803 3.48499 GeneID:92715,Genbank:NM_001346384.1,HGNC:HGNC:25199,MIM:613210 diphthamide biosynthesis 7 GO:0017183,GO:0061685 peptidyl-diphthamide biosynthetic process from peptidyl-histidine|diphthine methylesterase activity DPM1 816.090073470549 866.968064323582 765.212082617516 0.882630069210845 -0.180119197378108 0.257042451562632 1 18.93 20.5586 18.1149 17.7496 GeneID:8813,Genbank:NM_001317036.1,HGNC:HGNC:3005,MIM:603503 dolichyl-phosphate mannosyltransferase subunit 1, catalytic GO:0004169,GO:0004582,GO:0005634,GO:0005783,GO:0005789,GO:0006506,GO:0016020,GO:0018279,GO:0019348,GO:0033185,GO:0035268,GO:0035269 dolichyl-phosphate-mannose-protein mannosyltransferase activity|dolichyl-phosphate beta-D-mannosyltransferase activity|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor biosynthetic process|membrane|protein N-linked glycosylation via asparagine|dolichol metabolic process|dolichol-phosphate-mannose synthase complex|protein mannosylation|protein O-linked mannosylation hsa00510 N-Glycan biosynthesis DPM2 726.821168292029 694.256293429909 759.38604315415 1.09381225685758 0.129365133611077 0.453767671776219 1 14.7137 17.3201 17.5773 17.4413 GeneID:8818,Genbank:NM_003863.3,HGNC:HGNC:3006,MIM:603564 dolichyl-phosphate mannosyltransferase subunit 2, regulatory GO:0000506,GO:0005789,GO:0006506,GO:0016254,GO:0018279,GO:0019348,GO:0030176,GO:0030234,GO:0031647,GO:0033185,GO:0035269 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane|GPI anchor biosynthetic process|preassembly of GPI anchor in ER membrane|protein N-linked glycosylation via asparagine|dolichol metabolic process|integral component of endoplasmic reticulum membrane|enzyme regulator activity|regulation of protein stability|dolichol-phosphate-mannose synthase complex|protein O-linked mannosylation hsa00510,hsa00563 N-Glycan biosynthesis|Glycosylphosphatidylinositol (GPI)-anchor biosynthesis DPM3 327.748522544363 299.312871732089 356.184173356638 1.19000620085412 0.250969091111517 0.20076453292543 1 25.8786 24.9633 31.1298 33.4751 GeneID:54344,Genbank:XM_017001498.1,HGNC:HGNC:3007,MIM:605951 dolichyl-phosphate mannosyltransferase subunit 3 GO:0005783,GO:0005789,GO:0005975,GO:0006506,GO:0016020,GO:0018279,GO:0018406,GO:0030176,GO:0031501,GO:0031647,GO:0033185,GO:0035268,GO:0035269 endoplasmic reticulum|endoplasmic reticulum membrane|carbohydrate metabolic process|GPI anchor biosynthetic process|membrane|protein N-linked glycosylation via asparagine|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan|integral component of endoplasmic reticulum membrane|mannosyltransferase complex|regulation of protein stability|dolichol-phosphate-mannose synthase complex|protein mannosylation|protein O-linked mannosylation hsa00510 N-Glycan biosynthesis DPP3 1610.12084255646 1588.11064127625 1632.13104383667 1.02771872526781 0.0394454696030903 0.800483588772685 1 20.0501 20.793 20.5136 21.887 GeneID:10072,Genbank:NM_130443.3,HGNC:HGNC:3008,MIM:606818 dipeptidyl peptidase 3 GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0008237,GO:0008239,GO:0008270,GO:0016607,GO:0070062 cytoplasm|cytosol|plasma membrane|proteolysis|metallopeptidase activity|dipeptidyl-peptidase activity|zinc ion binding|nuclear speck|extracellular exosome DPP4 0.97013660517434 0 1.94027321034868 Inf Inf 0.496193947515089 1 0 0 0.041611 0 GeneID:1803,Genbank:XM_005246371.3,HGNC:HGNC:3009,MIM:102720 dipeptidyl peptidase 4 hsa04974 Protein digestion and absorption DPP7 1953.65619543502 1938.87018455789 1968.44220631214 1.01525219274079 0.0218381431970809 0.88965082727776 1 23.8787 24.1064 23.499 26.5119 GeneID:29952,Genbank:XM_011518600.1,HGNC:HGNC:14892,MIM:610537 dipeptidyl peptidase 7 GO:0005576,GO:0005794,GO:0005829,GO:0006508,GO:0008236,GO:0008239,GO:0031982,GO:0035578,GO:0043231,GO:0043312,GO:0070062 extracellular region|Golgi apparatus|cytosol|proteolysis|serine-type peptidase activity|dipeptidyl-peptidase activity|vesicle|azurophil granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome DPP8 789.852837427579 837.149127042483 742.556547812676 0.887006297714259 -0.172983747239404 0.588121493434267 1 4.18674 3.45782 4.16765 2.69406 GeneID:54878,Genbank:NM_017743.5,HGNC:HGNC:16490,MIM:606819 dipeptidyl peptidase 8 GO:0005737,GO:0005829,GO:0006508,GO:0006955,GO:0008236,GO:0008239 cytoplasm|cytosol|proteolysis|immune response|serine-type peptidase activity|dipeptidyl-peptidase activity DPP9 2607.36111203011 2461.43205051677 2753.29017354346 1.11857248830632 0.161658752267754 0.252836301623617 1 14.9404 15.9201 18.8174 16.3875 GeneID:91039,Genbank:XM_011528405.1,HGNC:HGNC:18648,MIM:608258 dipeptidyl peptidase 9 GO:0004177,GO:0005634,GO:0005829,GO:0008236,GO:0042802 aminopeptidase activity|nucleus|cytosol|serine-type peptidase activity|identical protein binding DPP9-AS1 28.7248517819987 30.797046083305 26.6526574806924 0.865429022270442 -0.208512592357773 0.720449105919564 1 0.0501018 0.0433469 0.0461702 0.0719317 GeneID:100131094,Genbank:NM_001242901.1,HGNC:HGNC:50706 DPP9 antisense RNA 1 GO:0004177,GO:0005634,GO:0005829,GO:0008236,GO:0042802 aminopeptidase activity|nucleus|cytosol|serine-type peptidase activity|identical protein binding DPY19L1 1640.28731993948 1605.49920371476 1675.0754361642 1.04333619866547 0.0612041185403738 0.761248534110459 1 16.9975 14.7929 19.383 13.9846 GeneID:23333,Genbank:NM_015283.1,HGNC:HGNC:22205,MIM:613892 dpy-19 like C-mannosyltransferase 1 GO:0000030,GO:0005637,GO:0016020,GO:0016021,GO:0018406 mannosyltransferase activity|nuclear inner membrane|membrane|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY19L2 92.0054165828311 102.576776486542 81.4340566791204 0.793883951791023 -0.332999962093061 0.282898128387376 1 0.409592 0.535815 0.475442 0.305112 GeneID:283417,Genbank:NM_173812.4,HGNC:HGNC:19414,MIM:613893 dpy-19 like 2 GO:0000030,GO:0005634,GO:0005637,GO:0007275,GO:0007286,GO:0016021,GO:0018406 mannosyltransferase activity|nucleus|nuclear inner membrane|multicellular organism development|spermatid development|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY19L3 409.334605741618 401.360342196242 417.308869286996 1.03973618071851 0.0562175100466761 0.76786854232555 1 3.07282 2.58725 3.36684 2.52607 GeneID:147991,Genbank:NM_001172774.1,HGNC:HGNC:27120,MIM:613894 dpy-19 like C-mannosyltransferase 3 GO:0000030,GO:0005637,GO:0016021,GO:0018406 mannosyltransferase activity|nuclear inner membrane|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY19L4 324.794301496383 367.026935094757 282.56166789801 0.769866298300585 -0.377320178336035 0.132767877287182 1 2.86475 2.22759 2.15423 1.77739 GeneID:286148,Genbank:XM_017013352.2,HGNC:HGNC:27829,MIM:613895 dpy-19 like 4 GO:0000030,GO:0005637,GO:0016021,GO:0018406 mannosyltransferase activity|nuclear inner membrane|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan DPY30 626.227754496436 674.316236427965 578.139272564907 0.857371128459648 -0.222008258942414 0.18052943018527 1 8.15623 8.46335 7.38942 7.43119 GeneID:84661,Genbank:NM_001321210.1,HGNC:HGNC:24590,MIM:612032 dpy-30, histone methyltransferase complex regulatory subunit GO:0000781,GO:0005634,GO:0005654,GO:0005794,GO:0005802,GO:0006348,GO:0006351,GO:0016197,GO:0018024,GO:0035097,GO:0042802,GO:0042803,GO:0044666,GO:0045652,GO:0048188,GO:0051568 chromosome, telomeric region|nucleus|nucleoplasm|Golgi apparatus|trans-Golgi network|chromatin silencing at telomere|transcription, DNA-templated|endosomal transport|histone-lysine N-methyltransferase activity|histone methyltransferase complex|identical protein binding|protein homodimerization activity|MLL3/4 complex|regulation of megakaryocyte differentiation|Set1C/COMPASS complex|histone H3-K4 methylation DPYD 505.920734020245 454.94080414301 556.900663897479 1.2241167616225 0.291741175170826 0.127459901549049 1 2.22681 2.20092 2.9327 2.39991 GeneID:1806,Genbank:XM_005270562.3,HGNC:HGNC:3012,MIM:612779 dihydropyrimidine dehydrogenase GO:0005737,GO:0005829,GO:0006145,GO:0006208,GO:0006210,GO:0006212,GO:0006214,GO:0017113,GO:0019483,GO:0042803,GO:0046135,GO:0046872,GO:0050660,GO:0050661,GO:0051539 cytoplasm|cytosol|purine nucleobase catabolic process|pyrimidine nucleobase catabolic process|thymine catabolic process|uracil catabolic process|thymidine catabolic process|dihydropyrimidine dehydrogenase (NADP+) activity|beta-alanine biosynthetic process|protein homodimerization activity|pyrimidine nucleoside catabolic process|metal ion binding|flavin adenine dinucleotide binding|NADP binding|4 iron, 4 sulfur cluster binding hsa00240,hsa00410,hsa00770,hsa00983 Pyrimidine metabolism|beta-Alanine metabolism|Pantothenate and CoA biosynthesis|Drug metabolism - other enzymes DPYS 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00533528 0 0 0 GeneID:1807,Genbank:NM_001385.2,HGNC:HGNC:3013,MIM:613326 dihydropyrimidinase GO:0002058,GO:0002059,GO:0004157,GO:0005829,GO:0006208,GO:0006210,GO:0006212,GO:0008270,GO:0016597,GO:0019482,GO:0046135,GO:0051219,GO:0051289,GO:0070062 uracil binding|thymine binding|dihydropyrimidinase activity|cytosol|pyrimidine nucleobase catabolic process|thymine catabolic process|uracil catabolic process|zinc ion binding|amino acid binding|beta-alanine metabolic process|pyrimidine nucleoside catabolic process|phosphoprotein binding|protein homotetramerization|extracellular exosome hsa00240,hsa00410,hsa00770,hsa00983 Pyrimidine metabolism|beta-Alanine metabolism|Pantothenate and CoA biosynthesis|Drug metabolism - other enzymes DPYSL2 2920.5914680116 2730.21336550088 3110.96957052231 1.13946023773552 0.18835058162588 0.165931059892221 1 21.3907 20.5486 25.9653 22.6367 GeneID:1808,Genbank:NM_001197293.2,HGNC:HGNC:3014,MIM:602463 dihydropyrimidinase like 2 GO:0004157,GO:0005829,GO:0005856,GO:0005886,GO:0006139,GO:0006897,GO:0007010,GO:0007165,GO:0007399,GO:0007411,GO:0007420,GO:0008017,GO:0030516,GO:0042802,GO:0070062 dihydropyrimidinase activity|cytosol|cytoskeleton|plasma membrane|nucleobase-containing compound metabolic process|endocytosis|cytoskeleton organization|signal transduction|nervous system development|axon guidance|brain development|microtubule binding|regulation of axon extension|identical protein binding|extracellular exosome hsa04360 Axon guidance DPYSL3 10084.5150584784 10681.7321118171 9487.29800513974 0.888179735816821 -0.171076438883038 0.191091048398588 1 63.9893 62.6905 56.322 56.9685 GeneID:1809,Genbank:NM_001197294.1,HGNC:HGNC:3015,MIM:601168 dihydropyrimidinase like 3 GO:0005615,GO:0005829,GO:0010976,GO:0010977,GO:0016810,GO:0017124,GO:0030027,GO:0030336,GO:0030426,GO:0031005,GO:0031941,GO:0035374,GO:0044297,GO:0048666,GO:0048678,GO:0051017,GO:0051260,GO:0051491,GO:0051764,GO:0070382,GO:0071345 extracellular space|cytosol|positive regulation of neuron projection development|negative regulation of neuron projection development|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|SH3 domain binding|lamellipodium|negative regulation of cell migration|growth cone|filamin binding|filamentous actin|chondroitin sulfate binding|cell body|neuron development|response to axon injury|actin filament bundle assembly|protein homooligomerization|positive regulation of filopodium assembly|actin crosslink formation|exocytic vesicle|cellular response to cytokine stimulus DPYSL4 707.470380025364 673.951643540702 740.989116510026 1.09946926253809 0.136807271856608 0.412289475619314 1 5.1911 5.54317 6.24363 6.01449 GeneID:10570,Genbank:XM_005252658.3,HGNC:HGNC:3016,MIM:608407 dihydropyrimidinase like 4 GO:0005829,GO:0007399,GO:0016810,GO:0031005,GO:0070997,GO:0097485 cytosol|nervous system development|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|filamin binding|neuron death|neuron projection guidance DPYSL5 435.188210062968 431.812412702499 438.564007423438 1.01563548087625 0.0223827010335515 0.916877504216544 1 2.94026 2.98587 2.90899 3.17827 GeneID:56896,Genbank:NM_020134.3,HGNC:HGNC:20637,MIM:608383 dihydropyrimidinase like 5 GO:0005829,GO:0007165,GO:0007399,GO:0007411,GO:0008017,GO:0016810,GO:0030425,GO:0043025 cytosol|signal transduction|nervous system development|axon guidance|microtubule binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|dendrite|neuronal cell body hsa04360 Axon guidance DQX1 1.24375355683899 1.51824048055703 0.969266633120943 0.638414431398462 -0.647434830746163 0.97445271569056 1 0.0141299 0 0.0132976 0 GeneID:165545,Genbank:NM_133637.2,HGNC:HGNC:20410 DEAQ-box RNA dependent ATPase 1 GO:0000398,GO:0003723,GO:0004004,GO:0005524,GO:0005681,GO:0005737 mRNA splicing, via spliceosome|RNA binding|ATP-dependent RNA helicase activity|ATP binding|spliceosomal complex|cytoplasm DR1 1910.62674122082 2020.70804068136 1800.54544176029 0.891046804145529 -0.166426880496852 0.246202805053494 1 34.5798 33.8467 34.5655 27.1426 GeneID:1810,Genbank:NM_001938.2,HGNC:HGNC:3017,MIM:601482 down-regulator of transcription 1 GO:0003677,GO:0005634,GO:0005671,GO:0006351,GO:0006355,GO:0017025,GO:0043966,GO:0046982 DNA binding|nucleus|Ada2/Gcn5/Ada3 transcription activator complex|transcription, DNA-templated|regulation of transcription, DNA-templated|TBP-class protein binding|histone H3 acetylation|protein heterodimerization activity DRAM1 1433.55051130317 1521.22079923662 1345.88022336971 0.884736932367151 -0.176679546796713 0.224069481230045 1 17.2955 17.6997 17.1264 14.4354 GeneID:55332,Genbank:XM_017019578.1,HGNC:HGNC:25645,MIM:610776 DNA damage regulated autophagy modulator 1 DRAM2 487.801205715467 491.954890972598 483.647520458336 0.983113552346561 -0.0245700334120587 0.909165039916954 1 7.61129 7.07928 7.36784 7.39866 GeneID:128338,Genbank:NM_001349885.1,HGNC:HGNC:28769,MIM:613360 DNA damage regulated autophagy modulator 2 GO:0001917,GO:0005737,GO:0005764,GO:0005765,GO:0005794,GO:0006914,GO:0006915,GO:0007601,GO:0010506,GO:0016021,GO:0016324,GO:0043231,GO:0045494 photoreceptor inner segment|cytoplasm|lysosome|lysosomal membrane|Golgi apparatus|autophagy|apoptotic process|visual perception|regulation of autophagy|integral component of membrane|apical plasma membrane|intracellular membrane-bounded organelle|photoreceptor cell maintenance DRAP1 4071.38813398836 4034.82194942493 4107.95431855179 1.01812530268833 0.0259151276636401 0.874324541226175 1 129.086 136.796 132.74 144.497 GeneID:10589,Genbank:NM_006442.3,HGNC:HGNC:3019,MIM:602289 DR1 associated protein 1 GO:0000122,GO:0003677,GO:0003700,GO:0003714,GO:0005634,GO:0006351,GO:0042802,GO:0046982 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|transcription, DNA-templated|identical protein binding|protein heterodimerization activity DRAXIN 11.5126829342852 10.4257696100515 12.5995962585189 1.20850514923825 0.273223620198785 0.770259490190842 1 0.103752 0.0462252 0.0888345 0.0906358 GeneID:374946,Genbank:XM_011541405.2,HGNC:HGNC:25054,MIM:612682 dorsal inhibitory axon guidance protein GO:0005576,GO:0007411,GO:0016055,GO:0021516,GO:0021528,GO:0030517,GO:0030900,GO:0043524,GO:0090090 extracellular region|axon guidance|Wnt signaling pathway|dorsal spinal cord development|commissural neuron differentiation in spinal cord|negative regulation of axon extension|forebrain development|negative regulation of neuron apoptotic process|negative regulation of canonical Wnt signaling pathway DRC1 0.780631827935889 1.07619535328461 0.48506830258717 0.450725141217823 -1.14968016979823 0.981241458110389 1 0.0253659 0 0.0120812 0 GeneID:92749,Genbank:NM_145038.4,HGNC:HGNC:24245,MIM:615288 dynein regulatory complex subunit 1 GO:0005930,GO:0007368,GO:0007507,GO:0060285,GO:0070286 axoneme|determination of left/right symmetry|heart development|cilium-dependent cell motility|axonemal dynein complex assembly DRC3 14.6417461512144 15.2304310802552 14.0530612221736 0.922696222327679 -0.116072344824571 0.906964784784116 1 0.0593376 0.0895135 0.0372895 0.0463955 GeneID:83450,Genbank:XM_011524023.2,HGNC:HGNC:25384 dynein regulatory complex subunit 3 GO:0005737,GO:0005930 cytoplasm|axoneme DRD2 436.050981998364 382.585775444409 489.516188552319 1.27949395918785 0.355573336068013 0.0907108975220266 0.97998510908004 4.62653 5.44126 7.20425 5.69294 GeneID:1813,Genbank:NM_016574.3,HGNC:HGNC:3023,MIM:126450 dopamine receptor D2 GO:0001591,GO:0001659,GO:0001666,GO:0001669,GO:0001963,GO:0001975,GO:0001976,GO:0002027,GO:0002028,GO:0002031,GO:0002052,GO:0002092,GO:0005622,GO:0005886,GO:0005887,GO:0006874,GO:0007186,GO:0007194,GO:0007195,GO:0007270,GO:0007409,GO:0007416,GO:0007608,GO:0007616,GO:0007625,GO:0007626,GO:0007628,GO:0007631,GO:0008104,GO:0008144,GO:0008285,GO:0008306,GO:0008542,GO:0009416,GO:0009636,GO:0010039,GO:0014059,GO:0014069,GO:0014854,GO:0015459,GO:0016055,GO:0016328,GO:0021756,GO:0021769,GO:0021853,GO:0021984,GO:0030139,GO:0030336,GO:0030424,GO:0030425,GO:0030432,GO:0030672,GO:0031223,GO:0032147,GO:0032228,GO:0032467,GO:0032922,GO:0033602,GO:0034776,GO:0035094,GO:0035240,GO:0035255,GO:0035556,GO:0035810,GO:0035815,GO:0036126,GO:0040018,GO:0042220,GO:0042321,GO:0042417,GO:0042493,GO:0042802,GO:0042803,GO:0043197,GO:0043204,GO:0043266,GO:0043278,GO:0043473,GO:0043666,GO:0043679,GO:0045745,GO:0045776,GO:0045824,GO:0045944,GO:0046676,GO:0046982,GO:0048148,GO:0048149,GO:0048169,GO:0048678,GO:0048755,GO:0050482,GO:0050709,GO:0051209,GO:0051481,GO:0051482,GO:0051584,GO:0051586,GO:0051823,GO:0051898,GO:0051967,GO:0060079,GO:0060124,GO:0060134,GO:0060158,GO:0060160,GO:0060170,GO:0070374,GO:0090325,GO:0097730,GO:1900168,GO:1900273,GO:1901386 dopamine neurotransmitter receptor activity, coupled via Gi/Go|temperature homeostasis|response to hypoxia|acrosomal vesicle|synaptic transmission, dopaminergic|response to amphetamine|neurological system process involved in regulation of systemic arterial blood pressure|regulation of heart rate|regulation of sodium ion transport|G-protein coupled receptor internalization|positive regulation of neuroblast proliferation|positive regulation of receptor internalization|intracellular|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|adenylate cyclase-inhibiting dopamine receptor signaling pathway|neuron-neuron synaptic transmission|axonogenesis|synapse assembly|sensory perception of smell|long-term memory|grooming behavior|locomotory behavior|adult walking behavior|feeding behavior|protein localization|drug binding|negative regulation of cell proliferation|associative learning|visual learning|response to light stimulus|response to toxic substance|response to iron ion|regulation of dopamine secretion|postsynaptic density|response to inactivity|potassium channel regulator activity|Wnt signaling pathway|lateral plasma membrane|striatum development|orbitofrontal cortex development|cerebral cortex GABAergic interneuron migration|adenohypophysis development|endocytic vesicle|negative regulation of cell migration|axon|dendrite|peristalsis|synaptic vesicle membrane|auditory behavior|activation of protein kinase activity|regulation of synaptic transmission, GABAergic|positive regulation of cytokinesis|circadian regulation of gene expression|negative regulation of dopamine secretion|response to histamine|response to nicotine|dopamine binding|ionotropic glutamate receptor binding|intracellular signal transduction|positive regulation of urine volume|positive regulation of renal sodium excretion|sperm flagellum|positive regulation of multicellular organism growth|response to cocaine|negative regulation of circadian sleep/wake cycle, sleep|dopamine metabolic process|response to drug|identical protein binding|protein homodimerization activity|dendritic spine|perikaryon|regulation of potassium ion transport|response to morphine|pigmentation|regulation of phosphoprotein phosphatase activity|axon terminus|positive regulation of G-protein coupled receptor protein signaling pathway|negative regulation of blood pressure|negative regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|negative regulation of insulin secretion|protein heterodimerization activity|behavioral response to cocaine|behavioral response to ethanol|regulation of long-term neuronal synaptic plasticity|response to axon injury|branching morphogenesis of a nerve|arachidonic acid secretion|negative regulation of protein secretion|release of sequestered calcium ion into cytosol|negative regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|regulation of dopamine uptake involved in synaptic transmission|positive regulation of dopamine uptake involved in synaptic transmission|regulation of synapse structural plasticity|negative regulation of protein kinase B signaling|negative regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|positive regulation of growth hormone secretion|prepulse inhibition|phospholipase C-activating dopamine receptor signaling pathway|negative regulation of dopamine receptor signaling pathway|ciliary membrane|positive regulation of ERK1 and ERK2 cascade|regulation of locomotion involved in locomotory behavior|non-motile cilium|positive regulation of glial cell-derived neurotrophic factor secretion|positive regulation of long-term synaptic potentiation|negative regulation of voltage-gated calcium channel activity hsa04015,hsa04024,hsa04080,hsa04540,hsa04728,hsa05012,hsa05030,hsa05034 Rap1 signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Gap junction|Dopaminergic synapse|Parkinson disease|Cocaine addiction|Alcoholism DRD4 4.97338264972424 5.58289052027075 4.36387477917774 0.781651505314867 -0.355402561032767 0.852568275916738 1 0.171389 0.269015 0.383549 0.0712667 GeneID:1815,Genbank:NM_000797.3,HGNC:HGNC:3025,MIM:126452 dopamine receptor D4 GO:0000187,GO:0001591,GO:0001662,GO:0001975,GO:0004952,GO:0005886,GO:0005887,GO:0006874,GO:0007186,GO:0007195,GO:0007212,GO:0008144,GO:0008344,GO:0015459,GO:0016020,GO:0017124,GO:0032417,GO:0033674,GO:0034776,GO:0035176,GO:0035240,GO:0042053,GO:0042417,GO:0042596,GO:0042752,GO:0042802,GO:0046872,GO:0048148,GO:0048149,GO:0048511,GO:0050482,GO:0050709,GO:0051379,GO:0051380,GO:0051586,GO:0060080,GO:0098794,GO:1901386 activation of MAPK activity|dopamine neurotransmitter receptor activity, coupled via Gi/Go|behavioral fear response|response to amphetamine|dopamine neurotransmitter receptor activity|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting dopamine receptor signaling pathway|dopamine receptor signaling pathway|drug binding|adult locomotory behavior|potassium channel regulator activity|membrane|SH3 domain binding|positive regulation of sodium:proton antiporter activity|positive regulation of kinase activity|response to histamine|social behavior|dopamine binding|regulation of dopamine metabolic process|dopamine metabolic process|fear response|regulation of circadian rhythm|identical protein binding|metal ion binding|behavioral response to cocaine|behavioral response to ethanol|rhythmic process|arachidonic acid secretion|negative regulation of protein secretion|epinephrine binding|norepinephrine binding|positive regulation of dopamine uptake involved in synaptic transmission|inhibitory postsynaptic potential|postsynapse|negative regulation of voltage-gated calcium channel activity hsa04080,hsa04728 Neuroactive ligand-receptor interaction|Dopaminergic synapse DRG1 1339.7795332637 1323.15958561011 1356.39948091729 1.02512160715055 0.0357950625370943 0.822903786859731 1 29.7541 32.8969 31.1278 33.4247 GeneID:4733,Genbank:NM_004147.3,HGNC:HGNC:3029,MIM:603952 developmentally regulated GTP binding protein 1 GO:0005525,GO:0005829,GO:0005844,GO:0006351,GO:0007275,GO:0008134,GO:0016020,GO:0016604,GO:0042802 GTP binding|cytosol|polysome|transcription, DNA-templated|multicellular organism development|transcription factor binding|membrane|nuclear body|identical protein binding DRG2 1050.48845843851 1070.20056630927 1030.77635056775 0.963161843693017 -0.054149854996172 0.714156282179541 1 15.6386 15.1987 15.1742 15.2765 GeneID:1819,Genbank:NM_001388.4,HGNC:HGNC:3030,MIM:602986 developmentally regulated GTP binding protein 2 GO:0005525,GO:0005654,GO:0005739,GO:0005829,GO:0007165,GO:0016020,GO:0043231 GTP binding|nucleoplasm|mitochondrion|cytosol|signal transduction|membrane|intracellular membrane-bounded organelle DRICH1 2.53216186662442 2.64246210852658 2.42186162472226 0.916517068270348 -0.125766346604802 1 1 0.0107404 0 0 0.0283811 GeneID:51233,Genbank:XM_011530206.1,HGNC:HGNC:28031 aspartate rich 1 DROSHA 1348.23922638225 1354.49269536835 1341.98575739616 0.990766330438729 -0.0133832530839041 0.946577395928189 1 5.76707 5.25379 5.9045 5.0634 GeneID:29102,Genbank:NM_013235.4,HGNC:HGNC:17904,MIM:608828 drosha ribonuclease III hsa03008,hsa05205 Ribosome biogenesis in eukaryotes|Proteoglycans in cancer DRP2 35.6696033486375 42.7410561739136 28.5981505233615 0.669102569833452 -0.579700709659718 0.231642514773189 1 0.220197 0.185593 0.165576 0.11958 GeneID:1821,Genbank:XM_017029333.1,HGNC:HGNC:3032,MIM:300052 dystrophin related protein 2 GO:0007417,GO:0008270,GO:0014069,GO:0030054,GO:0030425,GO:0043204,GO:0045211,GO:0050808 central nervous system development|zinc ion binding|postsynaptic density|cell junction|dendrite|perikaryon|postsynaptic membrane|synapse organization DSC2 1.48878925781767 2.00831188251439 0.969266633120943 0.482627544835033 -1.05101783854861 0.812641228941161 1 0.00790269 0.0228111 0.00764425 0 GeneID:1824,Genbank:NM_024422.4,HGNC:HGNC:3036,MIM:125645 desmocollin 2 GO:0001533,GO:0005509,GO:0005886,GO:0005913,GO:0007155,GO:0007156,GO:0009267,GO:0014704,GO:0016021,GO:0030057,GO:0031410,GO:0031424,GO:0070062,GO:0070268,GO:0086042,GO:0086073,GO:0086083,GO:0086091,GO:0098911 cornified envelope|calcium ion binding|plasma membrane|cell-cell adherens junction|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cellular response to starvation|intercalated disc|integral component of membrane|desmosome|cytoplasmic vesicle|keratinization|extracellular exosome|cornification|cardiac muscle cell-cardiac muscle cell adhesion|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|regulation of ventricular cardiac muscle cell action potential hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) DSCAML1 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.00865127 0 0 0 GeneID:57453,Genbank:NM_020693.3,HGNC:HGNC:14656,MIM:611782 DS cell adhesion molecule like 1 GO:0001709,GO:0005615,GO:0005886,GO:0007156,GO:0007409,GO:0007417,GO:0007420,GO:0009953,GO:0009986,GO:0016021,GO:0030054,GO:0042803,GO:0045202,GO:0048704 cell fate determination|extracellular space|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axonogenesis|central nervous system development|brain development|dorsal/ventral pattern formation|cell surface|integral component of membrane|cell junction|protein homodimerization activity|synapse|embryonic skeletal system morphogenesis DSCC1 254.875879000399 283.418864460498 226.332893540301 0.798580905936298 -0.324489517332047 0.131182408046285 1 5.44175 4.5381 4.35097 3.54404 GeneID:79075,Genbank:NM_024094.2,HGNC:HGNC:24453,MIM:613203 DNA replication and sister chromatid cohesion 1 GO:0000775,GO:0000785,GO:0003677,GO:0005654,GO:0006260,GO:0006275,GO:0031390,GO:0034088,GO:0034421,GO:1900264 chromosome, centromeric region|chromatin|DNA binding|nucleoplasm|DNA replication|regulation of DNA replication|Ctf18 RFC-like complex|maintenance of mitotic sister chromatid cohesion|post-translational protein acetylation|positive regulation of DNA-directed DNA polymerase activity DSE 505.258888108127 490.91691323889 519.600862977364 1.05842933695078 0.0819249550954833 0.739600290627333 1 2.13656 2.03888 2.77487 1.88269 GeneID:29940,Genbank:NM_001322937.1,HGNC:HGNC:21144,MIM:605942 dermatan sulfate epimerase GO:0000139,GO:0005654,GO:0005783,GO:0005794,GO:0005829,GO:0015012,GO:0016021,GO:0030206,GO:0030208,GO:0047757 Golgi membrane|nucleoplasm|endoplasmic reticulum|Golgi apparatus|cytosol|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|chondroitin sulfate biosynthetic process|dermatan sulfate biosynthetic process|chondroitin-glucuronate 5-epimerase activity hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate DSEL 427.123150765041 420.425100597894 433.821200932187 1.03186322680364 0.0452517545896286 0.872744904519828 1 1.96112 1.90168 2.44553 1.54116 GeneID:92126,Genbank:NM_032160.2,HGNC:HGNC:18144,MIM:611125 dermatan sulfate epimerase like GO:0000139,GO:0008146,GO:0016021,GO:0030204,GO:0030208,GO:0047757 Golgi membrane|sulfotransferase activity|integral component of membrane|chondroitin sulfate metabolic process|dermatan sulfate biosynthetic process|chondroitin-glucuronate 5-epimerase activity DSG2 660.145082066181 701.825844520769 618.464319611594 0.881221921991064 -0.182422709750513 0.417379915660127 1 4.70996 4.12842 4.59229 3.27826 GeneID:1829,Genbank:NM_001943.4,HGNC:HGNC:3049,MIM:125671 desmoglein 2 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) DSN1 1179.80218293761 1175.14923056473 1184.45513531049 1.00791891319308 0.0113795790761713 0.925402861750527 1 16.5642 15.9372 17.2367 15.481 GeneID:79980,Genbank:NM_001145318.1,HGNC:HGNC:16165,MIM:609175 DSN1 homolog, MIS12 kinetochore complex component GO:0000070,GO:0000444,GO:0000777,GO:0000818,GO:0000922,GO:0000941,GO:0001650,GO:0005576,GO:0005634,GO:0005730,GO:0005829,GO:0007062,GO:0016604,GO:0035578,GO:0043312,GO:0051301,GO:0051456 mitotic sister chromatid segregation|MIS12/MIND type complex|condensed chromosome kinetochore|nuclear MIS12/MIND complex|spindle pole|condensed nuclear chromosome inner kinetochore|fibrillar center|extracellular region|nucleus|nucleolus|cytosol|sister chromatid cohesion|nuclear body|azurophil granule lumen|neutrophil degranulation|cell division|attachment of spindle microtubules to kinetochore involved in meiotic sister chromatid segregation DSP 265.499792716606 242.551850000151 288.447735433061 1.18922092506357 0.25001675367593 0.656088511709116 1 0.749571 0.703048 1.22009 0.535967 GeneID:1832,Genbank:NM_004415.3,HGNC:HGNC:3052,MIM:125647 desmoplakin hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) DST 1355.90783130238 1259.47667831841 1452.33898428635 1.15312892194672 0.205553817981456 0.657125067156769 1 1.09516 0.922884 1.61709 0.808908 GeneID:667,Genbank:NM_001144769.2,HGNC:HGNC:1090,MIM:113810 dystonin GO:0000226,GO:0003779,GO:0005178,GO:0005509,GO:0005604,GO:0005634,GO:0005635,GO:0005737,GO:0005789,GO:0005829,GO:0005882,GO:0005925,GO:0005938,GO:0007010,GO:0007155,GO:0007229,GO:0008022,GO:0008090,GO:0009611,GO:0009925,GO:0015629,GO:0015630,GO:0016021,GO:0030011,GO:0030018,GO:0030056,GO:0030424,GO:0031252,GO:0031410,GO:0031581,GO:0031673,GO:0035371,GO:0042803,GO:0045104,GO:0045111,GO:0048870,GO:0051010,GO:0070062,GO:1904115 microtubule cytoskeleton organization|actin binding|integrin binding|calcium ion binding|basement membrane|nucleus|nuclear envelope|cytoplasm|endoplasmic reticulum membrane|cytosol|intermediate filament|focal adhesion|cell cortex|cytoskeleton organization|cell adhesion|integrin-mediated signaling pathway|protein C-terminus binding|retrograde axonal transport|response to wounding|basal plasma membrane|actin cytoskeleton|microtubule cytoskeleton|integral component of membrane|maintenance of cell polarity|Z disc|hemidesmosome|axon|cell leading edge|cytoplasmic vesicle|hemidesmosome assembly|H zone|microtubule plus-end|protein homodimerization activity|intermediate filament cytoskeleton organization|intermediate filament cytoskeleton|cell motility|microtubule plus-end binding|extracellular exosome|axon cytoplasm DSTN 5734.17085197095 5779.4865376362 5688.8551663057 0.984318438888939 -0.0228029745611484 0.867784937641765 1 113.793 115.17 111.9 113.701 GeneID:11034,Genbank:XM_011529144.1,HGNC:HGNC:15750,MIM:609114 destrin, actin depolymerizing factor GO:0005737,GO:0030043,GO:0030836,GO:0030864,GO:0051014,GO:0051015 cytoplasm|actin filament fragmentation|positive regulation of actin filament depolymerization|cortical actin cytoskeleton|actin filament severing|actin filament binding DSTYK 742.379752679023 713.194556316013 771.564949042033 1.08184357579442 0.113491914377383 0.484537485025924 1 3.32031 3.48109 4.07253 3.4972 GeneID:25778,Genbank:XM_011509392.2,HGNC:HGNC:29043,MIM:612666 dual serine/threonine and tyrosine protein kinase GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005737,GO:0005829,GO:0016323,GO:0016324,GO:0030054,GO:0033674,GO:0043066,GO:0044344,GO:0045743,GO:0070374 protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|cytoplasm|cytosol|basolateral plasma membrane|apical plasma membrane|cell junction|positive regulation of kinase activity|negative regulation of apoptotic process|cellular response to fibroblast growth factor stimulus|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade DTD1 1048.50949936084 1036.73264915297 1060.2863495687 1.02271916528816 0.0324100410084469 0.857929265014909 1 9.63175 10.7357 9.5993 11.0123 GeneID:92675,Genbank:NM_080820.5,HGNC:HGNC:16219,MIM:610996 D-tyrosyl-tRNA deacylase 1 GO:0000049,GO:0002161,GO:0003677,GO:0005730,GO:0005737,GO:0005829,GO:0006260,GO:0006399,GO:0046872,GO:0051500 tRNA binding|aminoacyl-tRNA editing activity|DNA binding|nucleolus|cytoplasm|cytosol|DNA replication|tRNA metabolic process|metal ion binding|D-tyrosyl-tRNA(Tyr) deacylase activity DTD2 288.222061353949 316.685884863805 259.758237844092 0.820239392594983 -0.285883063076999 0.159611618332304 1 5.06965 5.01595 4.19966 3.91558 GeneID:112487,Genbank:NM_080664.2,HGNC:HGNC:20277 D-tyrosyl-tRNA deacylase 2 (putative) GO:0002161,GO:0005737,GO:0006399,GO:0051500 aminoacyl-tRNA editing activity|cytoplasm|tRNA metabolic process|D-tyrosyl-tRNA(Tyr) deacylase activity DTL 1134.051224598 1119.86823169378 1148.23421750222 1.02532975309563 0.0360879649971171 0.853505434244189 1 9.15061 8.72871 10.694 7.72295 GeneID:51514,Genbank:NM_016448.3,HGNC:HGNC:30288,MIM:610617 denticleless E3 ubiquitin protein ligase homolog GO:0000209,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005813,GO:0005829,GO:0006260,GO:0006511,GO:0006513,GO:0006974,GO:0009411,GO:0010971,GO:0019985,GO:0031464,GO:0031465,GO:0031965,GO:0042769,GO:0043687,GO:0045732,GO:0051726,GO:0072425,GO:0080008 protein polyubiquitination|nucleus|nucleoplasm|chromosome|nucleolus|centrosome|cytosol|DNA replication|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|response to UV|positive regulation of G2/M transition of mitotic cell cycle|translesion synthesis|Cul4A-RING E3 ubiquitin ligase complex|Cul4B-RING E3 ubiquitin ligase complex|nuclear membrane|DNA damage response, detection of DNA damage|post-translational protein modification|positive regulation of protein catabolic process|regulation of cell cycle|signal transduction involved in G2 DNA damage checkpoint|Cul4-RING E3 ubiquitin ligase complex DTNA 372.177766650423 355.170185899265 389.18534740158 1.09577144381134 0.131946912106981 0.483815197592776 1 1.10043 1.07094 1.28377 0.991759 GeneID:1837,Genbank:NM_032975.3,HGNC:HGNC:3057,MIM:601239 dystrobrevin alpha GO:0005737,GO:0008270,GO:0016014,GO:0030054,GO:0042383,GO:0043234,GO:0045202 cytoplasm|zinc ion binding|dystrobrevin complex|cell junction|sarcolemma|protein complex|synapse DTNB 400.22064638212 405.483844166603 394.957448597636 0.974039913746498 -0.0379472032940081 0.823630160775986 1 0.783195 0.990999 0.875203 0.900957 GeneID:1838,Genbank:NM_001256304.2,HGNC:HGNC:3058,MIM:602415 dystrobrevin beta GO:0005737,GO:0008270,GO:0045202 cytoplasm|zinc ion binding|synapse DTNBP1 551.088259628368 553.126555322151 549.049963934585 0.992629912000532 -0.0106721652930079 0.958327577975986 1 3.20046 3.20341 3.20681 3.58808 GeneID:84062,Genbank:NM_032122.4,HGNC:HGNC:17328,MIM:607145 dystrobrevin binding protein 1 GO:0001956,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0007596,GO:0008089,GO:0010008,GO:0010628,GO:0014059,GO:0014069,GO:0015630,GO:0016528,GO:0030054,GO:0030424,GO:0030426,GO:0030496,GO:0030672,GO:0031083,GO:0031175,GO:0031532,GO:0032091,GO:0032438,GO:0033162,GO:0042383,GO:0043005,GO:0043197,GO:0043506,GO:0045211,GO:0048490,GO:0048812,GO:0048813,GO:0060155,GO:0060159,GO:0071901,GO:1904115 positive regulation of neurotransmitter secretion|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|blood coagulation|anterograde axonal transport|endosome membrane|positive regulation of gene expression|regulation of dopamine secretion|postsynaptic density|microtubule cytoskeleton|sarcoplasm|cell junction|axon|growth cone|midbody|synaptic vesicle membrane|BLOC-1 complex|neuron projection development|actin cytoskeleton reorganization|negative regulation of protein binding|melanosome organization|melanosome membrane|sarcolemma|neuron projection|dendritic spine|regulation of JUN kinase activity|postsynaptic membrane|anterograde synaptic vesicle transport|neuron projection morphogenesis|dendrite morphogenesis|platelet dense granule organization|regulation of dopamine receptor signaling pathway|negative regulation of protein serine/threonine kinase activity|axon cytoplasm DTWD1 305.448177712236 321.576790228271 289.319565196201 0.899690444048614 -0.152499395286095 0.453186073451972 1 0.641823 0.744033 0.742552 0.625737 GeneID:56986,Genbank:XM_017022427.1,HGNC:HGNC:30926 DTW domain containing 1 DTWD2 484.474115932494 504.609486528373 464.338745336616 0.920194244724148 -0.119989661630182 0.659918493915374 1 4.35384 3.61204 4.38381 3.10558 GeneID:285605,Genbank:NM_173666.3,HGNC:HGNC:19334 DTW domain containing 2 GO:1903955 positive regulation of protein targeting to mitochondrion DTX1 1.7784797117428 2.10436443188427 1.45259499160132 0.690277296837148 -0.534752059943747 0.969269437705094 1 0.0364658 0.010342 0 0.0313618 GeneID:1840,Genbank:XM_011538009.2,HGNC:HGNC:3060,MIM:602582 deltex E3 ubiquitin ligase 1 GO:0003713,GO:0005112,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006366,GO:0007166,GO:0007219,GO:0008270,GO:0008593,GO:0010001,GO:0016567,GO:0016604,GO:0016740,GO:0017124,GO:0031625,GO:0045581,GO:0045665,GO:1990830 transcription coactivator activity|Notch binding|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|transcription from RNA polymerase II promoter|cell surface receptor signaling pathway|Notch signaling pathway|zinc ion binding|regulation of Notch signaling pathway|glial cell differentiation|protein ubiquitination|nuclear body|transferase activity|SH3 domain binding|ubiquitin protein ligase binding|negative regulation of T cell differentiation|negative regulation of neuron differentiation|cellular response to leukemia inhibitory factor hsa04330 Notch signaling pathway DTX2 708.450378985526 704.019503849479 712.881254121572 1.01258736473015 0.0180463872322923 0.967618106323961 1 5.11124 6.20994 5.83592 5.58318 GeneID:113878,Genbank:NM_020892.2,HGNC:HGNC:15973,MIM:613141 deltex E3 ubiquitin ligase 2 GO:0005654,GO:0005737,GO:0007219,GO:0008270,GO:0016567,GO:0016740,GO:0031965 nucleoplasm|cytoplasm|Notch signaling pathway|zinc ion binding|protein ubiquitination|transferase activity|nuclear membrane hsa04330 Notch signaling pathway DTX3 718.277808448277 733.8834164027 702.672200493854 0.957471152486542 -0.0626990739506093 0.685865499295539 1 7.73209 8.03374 7.52224 8.1461 GeneID:196403,Genbank:XM_024448876.1,HGNC:HGNC:24457,MIM:613142 deltex E3 ubiquitin ligase 3 GO:0005737,GO:0007219,GO:0016567,GO:0016740,GO:0046872 cytoplasm|Notch signaling pathway|protein ubiquitination|transferase activity|metal ion binding hsa04330 Notch signaling pathway DTX3L 1432.0693031582 1036.59736198317 1827.54124433323 1.76301938569173 0.818048338235841 0.467959916036992 1 6.57008 7.07612 19.8006 4.73375 GeneID:151636,Genbank:NM_138287.3,HGNC:HGNC:30323,MIM:613143 deltex E3 ubiquitin ligase 3L GO:0000209,GO:0002230,GO:0003723,GO:0004842,GO:0004857,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0006302,GO:0006974,GO:0008047,GO:0008333,GO:0010390,GO:0015031,GO:0019899,GO:0031901,GO:0032092,GO:0033522,GO:0033523,GO:0035563,GO:0042393,GO:0042787,GO:0043234,GO:0044389,GO:0045087,GO:0045893,GO:0046872,GO:0051444,GO:0051607,GO:0051865,GO:0070936,GO:0097677,GO:1900182,GO:1901666,GO:1902966,GO:2000646,GO:2001034 protein polyubiquitination|positive regulation of defense response to virus by host|RNA binding|ubiquitin-protein transferase activity|enzyme inhibitor activity|nucleus|nucleoplasm|cytoplasm|lysosome|lysosomal membrane|cytosol|double-strand break repair|cellular response to DNA damage stimulus|enzyme activator activity|endosome to lysosome transport|histone monoubiquitination|protein transport|enzyme binding|early endosome membrane|positive regulation of protein binding|histone H2A ubiquitination|histone H2B ubiquitination|positive regulation of chromatin binding|histone binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein complex|ubiquitin-like protein ligase binding|innate immune response|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of ubiquitin-protein transferase activity|defense response to virus|protein autoubiquitination|protein K48-linked ubiquitination|STAT family protein binding|positive regulation of protein localization to nucleus|positive regulation of NAD+ ADP-ribosyltransferase activity|positive regulation of protein localization to early endosome|positive regulation of receptor catabolic process|positive regulation of double-strand break repair via nonhomologous end joining hsa04330 Notch signaling pathway DTX4 54.5307041858252 65.4470197973682 43.6143885742822 0.666407556972306 -0.585523334122897 0.241383342447103 1 0.496895 0.294726 0.246082 0.247228 GeneID:23220,Genbank:NM_001300727.1,HGNC:HGNC:29151,MIM:616110 deltex E3 ubiquitin ligase 4 GO:0004842,GO:0005829,GO:0007219,GO:0008270,GO:0032479 ubiquitin-protein transferase activity|cytosol|Notch signaling pathway|zinc ion binding|regulation of type I interferon production hsa04330 Notch signaling pathway DTYMK 2368.30183919508 2399.78012342036 2336.82355496979 0.973765693016556 -0.0383534213359277 0.761307555827189 1 63.8467 62.7927 60.4728 63.137 GeneID:1841,Genbank:NM_001320902.1,HGNC:HGNC:3061,MIM:188345 deoxythymidylate kinase GO:0004798,GO:0005524,GO:0005737,GO:0005758,GO:0005759,GO:0005829,GO:0006227,GO:0006233,GO:0006235,GO:0007049,GO:0008283,GO:0009041,GO:0015949,GO:0043627,GO:0045445,GO:0046686,GO:0050145,GO:0071363 thymidylate kinase activity|ATP binding|cytoplasm|mitochondrial intermembrane space|mitochondrial matrix|cytosol|dUDP biosynthetic process|dTDP biosynthetic process|dTTP biosynthetic process|cell cycle|cell proliferation|uridylate kinase activity|nucleobase-containing small molecule interconversion|response to estrogen|myoblast differentiation|response to cadmium ion|nucleoside phosphate kinase activity|cellular response to growth factor stimulus hsa00240 Pyrimidine metabolism DUOX1 3.98129947086583 6.02493564754317 1.93766329418849 0.321607301312608 -1.63662793511206 0.311892249696117 1 0 0.0419884 0.00744486 0.0208359 GeneID:53905,Genbank:NM_017434.4,HGNC:HGNC:3062,MIM:606758 dual oxidase 1 GO:0004601,GO:0005509,GO:0005886,GO:0006590,GO:0006979,GO:0016021,GO:0016174,GO:0016324,GO:0019221,GO:0020037,GO:0042335,GO:0042446,GO:0042554,GO:0042744,GO:0050661,GO:0050665,GO:0051591,GO:0055114 peroxidase activity|calcium ion binding|plasma membrane|thyroid hormone generation|response to oxidative stress|integral component of membrane|NAD(P)H oxidase activity|apical plasma membrane|cytokine-mediated signaling pathway|heme binding|cuticle development|hormone biosynthetic process|superoxide anion generation|hydrogen peroxide catabolic process|NADP binding|hydrogen peroxide biosynthetic process|response to cAMP|oxidation-reduction process DUOX2 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0069311 0 0.00646585 0 GeneID:50506,Genbank:XM_005254421.3,HGNC:HGNC:13273,MIM:606759 dual oxidase 2 hsa04918 Thyroid hormone synthesis DUOXA1 1.45890304905161 0.980142803914724 1.93766329418849 1.97691936975856 0.983254030793153 0.869518558966023 1 0 0.0162109 0 0 GeneID:90527,Genbank:XM_006720746.1,HGNC:HGNC:26507,MIM:612771 dual oxidase maturation factor 1 GO:0005789,GO:0005886,GO:0015031,GO:0016020,GO:0016021,GO:0042743,GO:0045666,GO:0050727,GO:2000379,GO:2000609 endoplasmic reticulum membrane|plasma membrane|protein transport|membrane|integral component of membrane|hydrogen peroxide metabolic process|positive regulation of neuron differentiation|regulation of inflammatory response|positive regulation of reactive oxygen species metabolic process|regulation of thyroid hormone generation DUS1L 1957.29206240162 1788.04793061803 2126.53619418521 1.18930603468229 0.250120000119627 0.0826443363780552 0.963076417285947 24.2443 27.0912 32.5481 31.4315 GeneID:64118,Genbank:NM_022156.4,HGNC:HGNC:30086 dihydrouridine synthase 1 like GO:0017150,GO:0050660 tRNA dihydrouridine synthase activity|flavin adenine dinucleotide binding DUS2 409.052902693452 411.03730872155 407.068496665354 0.990344399469382 -0.0139977747429799 0.949143857918552 1 6.60738 6.16422 6.17887 6.68638 GeneID:54920,Genbank:NM_017803.4,HGNC:HGNC:26014,MIM:609707 dihydrouridine synthase 2 GO:0003725,GO:0004860,GO:0005739,GO:0005783,GO:0005829,GO:0017150,GO:0050660,GO:0060548 double-stranded RNA binding|protein kinase inhibitor activity|mitochondrion|endoplasmic reticulum|cytosol|tRNA dihydrouridine synthase activity|flavin adenine dinucleotide binding|negative regulation of cell death DUS3L 929.268277426539 959.101487891566 899.435066961512 0.937789252041281 -0.0926643503942081 0.525983998967068 1 17.7102 19.6354 17.8443 17.8064 GeneID:56931,Genbank:XM_017027020.1,HGNC:HGNC:26920 dihydrouridine synthase 3 like GO:0003723,GO:0017150,GO:0046872,GO:0050660 RNA binding|tRNA dihydrouridine synthase activity|metal ion binding|flavin adenine dinucleotide binding DUS4L 118.331981579887 127.118564203987 109.545398955788 0.861757679861775 -0.214645844144685 0.466803588492998 1 1.28603 1.72342 1.68527 1.17433 GeneID:11062,Genbank:NM_181581.2,HGNC:HGNC:21517 dihydrouridine synthase 4 like GO:0017150,GO:0050660 tRNA dihydrouridine synthase activity|flavin adenine dinucleotide binding DUSP1 554.882335487245 535.024356415908 574.740314558583 1.07423205629129 0.103305678889109 0.636815562403374 1 11.6629 14.4536 13.969 14.8578 GeneID:1843,Genbank:NM_004417.3,HGNC:HGNC:3064,MIM:600714 dual specificity phosphatase 1 hsa04010,hsa04726,hsa05418 MAPK signaling pathway|Serotonergic synapse|Fluid shear stress and atherosclerosis DUSP10 676.232111285883 659.383771650928 693.080450920838 1.05110328873509 0.0719044455361248 0.66666522390717 1 2.87281 2.9868 3.57866 2.70931 GeneID:11221,Genbank:NM_007207.5,HGNC:HGNC:3065,MIM:608867 dual specificity phosphatase 10 hsa04010 MAPK signaling pathway DUSP11 364.326836271878 392.338160208016 336.315512335739 0.857208261764357 -0.22228234012602 0.240332843606988 1 8.77854 8.96504 7.23609 7.85259 GeneID:8446,Genbank:NM_003584.2,HGNC:HGNC:3066,MIM:603092 dual specificity phosphatase 11 GO:0001650,GO:0003723,GO:0004651,GO:0004725,GO:0005634,GO:0006396,GO:0006470,GO:0008138,GO:0016070,GO:0016607,GO:0016791,GO:0045171,GO:0098507,GO:0098519 fibrillar center|RNA binding|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|nucleus|RNA processing|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|RNA metabolic process|nuclear speck|phosphatase activity|intercellular bridge|polynucleotide 5' dephosphorylation|nucleotide phosphatase activity, acting on free nucleotides DUSP12 663.900104017733 705.517110018966 622.2830980165 0.882024105694292 -0.181110009750396 0.265586189840268 1 20.4166 21.5318 20.2271 17.4607 GeneID:11266,Genbank:NM_007240.2,HGNC:HGNC:3067,MIM:604835 dual specificity phosphatase 12 GO:0003676,GO:0004725,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0008138,GO:0008270,GO:0016311,GO:0016791,GO:0019900,GO:0033133 nucleic acid binding|protein tyrosine phosphatase activity|nucleus|cytoplasm|cytosol|cellular protein modification process|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding|dephosphorylation|phosphatase activity|kinase binding|positive regulation of glucokinase activity DUSP14 1331.23589801656 1343.31034802016 1319.16144801296 0.982022843758492 -0.0261715100686039 0.839038521651084 1 18.0813 20.1751 19.6727 18.7281 GeneID:11072,Genbank:XM_011524234.1,HGNC:HGNC:17007,MIM:606618 dual specificity phosphatase 14 GO:0003723,GO:0004725,GO:0017017,GO:0035335 RNA binding|protein tyrosine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation DUSP15 7.95096116535958 9.59951428529953 6.30240804541962 0.656534055589769 -0.607058246669164 0.57667307862806 1 0.0283281 0.0246758 0.0914963 0.0122416 GeneID:128853,Genbank:XM_017027656.1,HGNC:HGNC:16236,MIM:616776 dual specificity phosphatase 15 GO:0000122,GO:0004725,GO:0005886,GO:0008138,GO:0016311,GO:0016791,GO:0048713,GO:0070374 negative regulation of transcription from RNA polymerase II promoter|protein tyrosine phosphatase activity|plasma membrane|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|regulation of oligodendrocyte differentiation|positive regulation of ERK1 and ERK2 cascade DUSP16 1110.79181814106 988.070484534279 1233.51315174785 1.24840603079977 0.320087231757706 0.0854762976527393 0.964561165794104 5.9131 5.47262 8.37933 6.12069 GeneID:80824,Genbank:NM_030640.2,HGNC:HGNC:17909,MIM:607175 dual specificity phosphatase 16 GO:0000188,GO:0004721,GO:0004725,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016311,GO:0016791,GO:0017017,GO:0031410,GO:0045204,GO:0045209 inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|nucleus|nucleoplasm|cytoplasm|cytosol|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|cytoplasmic vesicle|MAPK export from nucleus|MAPK phosphatase export from nucleus, leptomycin B sensitive hsa04010 MAPK signaling pathway DUSP18 95.2653991564128 106.199381398983 84.3314169138424 0.794085763993441 -0.332633263078221 0.277092416155965 1 0.860792 0.905284 0.780623 0.604485 GeneID:150290,Genbank:NM_001304795.1,HGNC:HGNC:18484,MIM:611446 dual specificity phosphatase 18 GO:0004725,GO:0005634,GO:0005654,GO:0005737,GO:0005743,GO:0008138,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970 protein tyrosine phosphatase activity|nucleus|nucleoplasm|cytoplasm|mitochondrial inner membrane|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation DUSP19 32.7382853511907 29.1347267786932 36.3418439236883 1.247372051907 0.31889183997454 0.543582952305881 1 0.258652 0.323887 0.310999 0.364082 GeneID:142679,Genbank:NM_080876.3,HGNC:HGNC:18894,MIM:611437 dual specificity phosphatase 19 GO:0004725,GO:0004860,GO:0005078,GO:0006469,GO:0008579,GO:0030295,GO:0031435,GO:0043410,GO:0043507,GO:0043508,GO:0045860,GO:0046329,GO:0046330 protein tyrosine phosphatase activity|protein kinase inhibitor activity|MAP-kinase scaffold activity|negative regulation of protein kinase activity|JUN kinase phosphatase activity|protein kinase activator activity|mitogen-activated protein kinase kinase kinase binding|positive regulation of MAPK cascade|positive regulation of JUN kinase activity|negative regulation of JUN kinase activity|positive regulation of protein kinase activity|negative regulation of JNK cascade|positive regulation of JNK cascade DUSP2 4.95947448293838 8.46548400222204 1.45346496365472 0.171693073104055 -2.54209625939132 0.227523194045002 1 0.553176 0.108276 0.0393768 0.0733254 GeneID:1844,Genbank:XM_017003546.1,HGNC:HGNC:3068,MIM:603068 dual specificity phosphatase 2 GO:0000188,GO:0001706,GO:0004725,GO:0005634,GO:0006470,GO:0008330,GO:0017017,GO:0031965,GO:0051019 inactivation of MAPK activity|endoderm formation|protein tyrosine phosphatase activity|nucleus|protein dephosphorylation|protein tyrosine/threonine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|nuclear membrane|mitogen-activated protein kinase binding hsa04010 MAPK signaling pathway DUSP22 492.673505739419 401.379959506457 583.96705197238 1.45489837781247 0.540918386847582 0.00192408923980793 0.155161689175677 2.02783 1.85677 2.90236 2.80607 GeneID:56940,Genbank:NM_001286555.1,HGNC:HGNC:16077,MIM:616778 dual specificity phosphatase 22 GO:0000122,GO:0000188,GO:0002710,GO:0004725,GO:0005634,GO:0005737,GO:0006470,GO:0006915,GO:0007179,GO:0007275,GO:0008138,GO:0008283,GO:0042127,GO:0046330,GO:0050860,GO:0050868 negative regulation of transcription from RNA polymerase II promoter|inactivation of MAPK activity|negative regulation of T cell mediated immunity|protein tyrosine phosphatase activity|nucleus|cytoplasm|protein dephosphorylation|apoptotic process|transforming growth factor beta receptor signaling pathway|multicellular organism development|protein tyrosine/serine/threonine phosphatase activity|cell proliferation|regulation of cell proliferation|positive regulation of JNK cascade|negative regulation of T cell receptor signaling pathway|negative regulation of T cell activation DUSP26 18.0510273811713 19.1411936408062 16.9608611215364 0.88609213405471 -0.17447137981684 0.848349453313637 1 0.393356 0.214485 0.365414 0.362449 GeneID:78986,Genbank:NM_001305115.1,HGNC:HGNC:28161 dual specificity phosphatase 26 GO:0000122,GO:0001102,GO:0002039,GO:0004647,GO:0004721,GO:0004725,GO:0005634,GO:0005737,GO:0005739,GO:0005794,GO:0006470,GO:0008138,GO:0044387,GO:0045785,GO:0070062,GO:0070373,GO:1902310 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II activating transcription factor binding|p53 binding|phosphoserine phosphatase activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|nucleus|cytoplasm|mitochondrion|Golgi apparatus|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of cell adhesion|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine dephosphorylation DUSP27 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00715811 0 GeneID:92235,Genbank:XM_011510146.2,HGNC:HGNC:25034 dual specificity phosphatase 27, atypical GO:0008138,GO:0030017 protein tyrosine/serine/threonine phosphatase activity|sarcomere DUSP28 98.1055470563933 89.1145259153764 107.09656819741 1.20178575936217 0.265179731777807 0.386927006186194 1 0.581847 0.611436 0.656193 0.81384 GeneID:285193,Genbank:XM_024452814.1,HGNC:HGNC:33237 dual specificity phosphatase 28 GO:0004725,GO:0008138,GO:0016311,GO:0016791,GO:0035335 protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|peptidyl-tyrosine dephosphorylation DUSP3 3110.83194620026 2641.06941362018 3580.59447878035 1.35573660439024 0.439076915604646 0.00120765547161081 0.11383325497048 26.5253 25.1021 38.5613 33.1848 GeneID:1845,Genbank:NM_004090.3,HGNC:HGNC:3069,MIM:600183 dual specificity phosphatase 3 GO:0000188,GO:0001701,GO:0001772,GO:0004725,GO:0005634,GO:0005654,GO:0005829,GO:0008138,GO:0016311,GO:0016791,GO:0019901,GO:0033549,GO:0035335,GO:0043409,GO:0045931,GO:0046329,GO:0050860,GO:0050868,GO:0070062,GO:0070373 inactivation of MAPK activity|in utero embryonic development|immunological synapse|protein tyrosine phosphatase activity|nucleus|nucleoplasm|cytosol|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|protein kinase binding|MAP kinase phosphatase activity|peptidyl-tyrosine dephosphorylation|negative regulation of MAPK cascade|positive regulation of mitotic cell cycle|negative regulation of JNK cascade|negative regulation of T cell receptor signaling pathway|negative regulation of T cell activation|extracellular exosome|negative regulation of ERK1 and ERK2 cascade hsa04010 MAPK signaling pathway DUSP4 1155.56469104631 1173.62321543078 1137.50616666183 0.969226027319432 -0.045094947856567 0.751494689390856 1 5.21141 5.69113 5.90008 4.75621 GeneID:1846,Genbank:NM_001394.6,HGNC:HGNC:3070,MIM:602747 dual specificity phosphatase 4 GO:0000188,GO:0001706,GO:0004725,GO:0005634,GO:0005654,GO:0008330,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970,GO:0070373,GO:1990439 inactivation of MAPK activity|endoderm formation|protein tyrosine phosphatase activity|nucleus|nucleoplasm|protein tyrosine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation|negative regulation of ERK1 and ERK2 cascade|MAP kinase serine/threonine phosphatase activity hsa04010 MAPK signaling pathway DUSP5 195.923772195888 200.89679783463 190.950746557146 0.950491738122818 -0.0732540081724429 0.754635825087582 1 3.79175 3.94633 4.02981 3.56989 GeneID:1847,Genbank:NM_004419.3,HGNC:HGNC:3071,MIM:603069 dual specificity phosphatase 5 GO:0000165,GO:0000187,GO:0001706,GO:0004725,GO:0005654,GO:0006470,GO:0008138,GO:0016311,GO:0016791,GO:0017017,GO:0035335,GO:0035970 MAPK cascade|activation of MAPK activity|endoderm formation|protein tyrosine phosphatase activity|nucleoplasm|protein dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|peptidyl-threonine dephosphorylation hsa04010 MAPK signaling pathway DUSP6 398.128675050626 358.148831930586 438.108518170666 1.22325826335677 0.290729028500422 0.112544602233297 1 5.16912 4.95252 6.48174 6.15997 GeneID:1848,Genbank:NM_022652.3,HGNC:HGNC:3072,MIM:602748 dual specificity phosphatase 6 hsa04010,hsa05202,hsa05221 MAPK signaling pathway|Transcriptional misregulation in cancer|Acute myeloid leukemia DUSP7 1208.18527776689 1293.91020597269 1122.4603495611 0.86749478007038 -0.205073018221517 0.158562027019271 1 20.0666 21.648 19.9455 16.9813 GeneID:1849,Genbank:NM_001947.3,HGNC:HGNC:3073,MIM:602749 dual specificity phosphatase 7 GO:0000165,GO:0000187,GO:0004725,GO:0005654,GO:0005829,GO:0008138,GO:0017017,GO:0035335,GO:0043407 MAPK cascade|activation of MAPK activity|protein tyrosine phosphatase activity|nucleoplasm|cytosol|protein tyrosine/serine/threonine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity|peptidyl-tyrosine dephosphorylation|negative regulation of MAP kinase activity hsa04010 MAPK signaling pathway DUSP8 299.636203380628 283.775682694363 315.496724066894 1.11178209870328 0.152874057913196 0.484593688716709 1 2.98497 3.62178 3.79354 3.626 GeneID:1850,Genbank:XM_011519933.2,HGNC:HGNC:3074,MIM:602038 dual specificity phosphatase 8 GO:0000188,GO:0004725,GO:0005634,GO:0005737,GO:0016311,GO:0016791,GO:0017017 inactivation of MAPK activity|protein tyrosine phosphatase activity|nucleus|cytoplasm|dephosphorylation|phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity hsa04010 MAPK signaling pathway DUSP9 1.48378615844747 1.02816907859967 1.93940323829528 1.88626878464064 0.915535268080234 0.868235938463046 1 0.0229417 0.0192033 0.0632114 0.0197035 GeneID:1852,Genbank:NM_001395.3,HGNC:HGNC:3076,MIM:300134 dual specificity phosphatase 9 GO:0000165,GO:0000187,GO:0000188,GO:0004721,GO:0004725,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0007254,GO:0008138,GO:0017017 MAPK cascade|activation of MAPK activity|inactivation of MAPK activity|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|nucleus|cytoplasm|cytosol|protein dephosphorylation|JNK cascade|protein tyrosine/serine/threonine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity hsa04010,hsa04550 MAPK signaling pathway|Signaling pathways regulating pluripotency of stem cells DUT 2946.07149158893 3050.82963023545 2841.31335294241 0.931324818922493 -0.102643669402318 0.455376591295458 1 34.6458 34.8765 32.4992 33.327 GeneID:1854,Genbank:NM_001330286.1,HGNC:HGNC:3078,MIM:601266 deoxyuridine triphosphatase hsa00240,hsa00983 Pyrimidine metabolism|Drug metabolism - other enzymes DVL1 2275.54543133725 2320.37198999562 2230.71887267889 0.961362610088694 -0.0568474005113921 0.652181738897878 1 27.6342 29.7247 28.6597 27.8766 GeneID:1855,Genbank:XM_005244732.4,HGNC:HGNC:3084,MIM:601365 dishevelled segment polarity protein 1 GO:0005109,GO:0005829,GO:0005886,GO:0031410,GO:0035556,GO:0060070,GO:0090179 frizzled binding|cytosol|plasma membrane|cytoplasmic vesicle|intracellular signal transduction|canonical Wnt signaling pathway|planar cell polarity pathway involved in neural tube closure hsa04150,hsa04310,hsa04330,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Notch signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer DVL2 2082.80669601384 1902.4706306441 2263.14276138358 1.18958091911115 0.250453411846873 0.075296097200706 0.94157495521624 25.4378 24.6451 30.0276 31.35 GeneID:1856,Genbank:XM_005256502.2,HGNC:HGNC:3086,MIM:602151 dishevelled segment polarity protein 2 GO:0001843,GO:0001934,GO:0003151,GO:0005109,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006366,GO:0007379,GO:0007507,GO:0016055,GO:0016235,GO:0016328,GO:0016604,GO:0019901,GO:0019904,GO:0022007,GO:0030674,GO:0031410,GO:0034613,GO:0035329,GO:0035567,GO:0042802,GO:0043507,GO:0043547,GO:0043621,GO:0044340,GO:0045177,GO:0045334,GO:0045893,GO:0048365,GO:0051091,GO:0051259,GO:0060070,GO:0060071,GO:0061024,GO:0061098,GO:0090090,GO:0090103,GO:0090179,GO:0090263,GO:1904886 neural tube closure|positive regulation of protein phosphorylation|outflow tract morphogenesis|frizzled binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription from RNA polymerase II promoter|segment specification|heart development|Wnt signaling pathway|aggresome|lateral plasma membrane|nuclear body|protein kinase binding|protein domain specific binding|convergent extension involved in neural plate elongation|protein binding, bridging|cytoplasmic vesicle|cellular protein localization|hippo signaling|non-canonical Wnt signaling pathway|identical protein binding|positive regulation of JUN kinase activity|positive regulation of GTPase activity|protein self-association|canonical Wnt signaling pathway involved in regulation of cell proliferation|apical part of cell|clathrin-coated endocytic vesicle|positive regulation of transcription, DNA-templated|Rac GTPase binding|positive regulation of DNA binding transcription factor activity|protein oligomerization|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|membrane organization|positive regulation of protein tyrosine kinase activity|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|positive regulation of canonical Wnt signaling pathway|beta-catenin destruction complex disassembly hsa04150,hsa04310,hsa04330,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Notch signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer DVL3 3123.36019850921 2970.11497873911 3276.60541827932 1.1031914392992 0.141683166779157 0.30199678458272 1 20.5295 20.3961 24.0901 22.8234 GeneID:1857,Genbank:XM_005247172.2,HGNC:HGNC:3087,MIM:601368 dishevelled segment polarity protein 3 GO:0000790,GO:0001934,GO:0002020,GO:0005102,GO:0005109,GO:0005829,GO:0008013,GO:0016055,GO:0035556,GO:0035567,GO:0038031,GO:0042493,GO:0043507,GO:0043547,GO:0045893,GO:0046982,GO:0048365,GO:0050821,GO:0060070,GO:0060071,GO:0090090,GO:0090179,GO:1903827,GO:1904886 nuclear chromatin|positive regulation of protein phosphorylation|protease binding|receptor binding|frizzled binding|cytosol|beta-catenin binding|Wnt signaling pathway|intracellular signal transduction|non-canonical Wnt signaling pathway|non-canonical Wnt signaling pathway via JNK cascade|response to drug|positive regulation of JUN kinase activity|positive regulation of GTPase activity|positive regulation of transcription, DNA-templated|protein heterodimerization activity|Rac GTPase binding|protein stabilization|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|negative regulation of canonical Wnt signaling pathway|planar cell polarity pathway involved in neural tube closure|regulation of cellular protein localization|beta-catenin destruction complex disassembly hsa04150,hsa04310,hsa04330,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Notch signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer DXO 695.043058063726 717.422902489997 672.663213637454 0.937610454451351 -0.0929394388419697 0.559468198089339 1 12.6438 12.6367 12.2844 11.6711 GeneID:1797,Genbank:NM_005510.3,HGNC:HGNC:2992,MIM:605996 decapping exoribonuclease GO:0000166,GO:0000287,GO:0003729,GO:0005634,GO:0005829,GO:0005886,GO:0006402,GO:0008409,GO:0034353,GO:0050779,GO:0071028,GO:0090305 nucleotide binding|magnesium ion binding|mRNA binding|nucleus|cytosol|plasma membrane|mRNA catabolic process|5'-3' exonuclease activity|RNA pyrophosphohydrolase activity|RNA destabilization|nuclear mRNA surveillance|nucleic acid phosphodiester bond hydrolysis DYDC2 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0175777 0 0 0 GeneID:84332,Genbank:NM_001270042.1,HGNC:HGNC:23468 DPY30 domain containing 2 GO:0000781,GO:0006348,GO:0048188,GO:0051568 chromosome, telomeric region|chromatin silencing at telomere|Set1C/COMPASS complex|histone H3-K4 methylation DYM 343.027113183245 309.978772715565 376.075453650926 1.21322970071893 0.278852721699366 0.146578010770891 1 1.00765 1.07905 1.30238 1.15263 GeneID:54808,Genbank:NM_001353211.1,HGNC:HGNC:21317,MIM:607461 dymeclin GO:0005737,GO:0005794,GO:0007030,GO:0016020,GO:0019899,GO:0060348 cytoplasm|Golgi apparatus|Golgi organization|membrane|enzyme binding|bone development DYNC1H1 15093.4993224809 14419.175100155 15767.8235448068 1.09353159492718 0.128994904141166 0.593403331425266 1 32.8679 33.6382 44.2916 30.0027 GeneID:1778,Genbank:NM_001376.4,HGNC:HGNC:2961,MIM:600112 dynein cytoplasmic 1 heavy chain 1 hsa04145,hsa04962,hsa05132 Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1I1 1386.99307683636 1313.85600362632 1460.1301500464 1.11133194658803 0.152289803376576 0.287781924182744 1 7.6666 7.15498 8.18194 8.49535 GeneID:1780,Genbank:NM_001278422.1,HGNC:HGNC:2963,MIM:603772 dynein cytoplasmic 1 intermediate chain 1 GO:0000776,GO:0000777,GO:0000922,GO:0003774,GO:0003777,GO:0005634,GO:0005737,GO:0005829,GO:0005868,GO:0005874,GO:0006888,GO:0007062,GO:0008017,GO:0019886,GO:0030507,GO:0031982,GO:0036464,GO:0045503,GO:0045504,GO:0047496,GO:0048471,GO:0055037,GO:2000582 kinetochore|condensed chromosome kinetochore|spindle pole|motor activity|microtubule motor activity|nucleus|cytoplasm|cytosol|cytoplasmic dynein complex|microtubule|ER to Golgi vesicle-mediated transport|sister chromatid cohesion|microtubule binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|spectrin binding|vesicle|cytoplasmic ribonucleoprotein granule|dynein light chain binding|dynein heavy chain binding|vesicle transport along microtubule|perinuclear region of cytoplasm|recycling endosome|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed hsa04145,hsa04962,hsa05132 Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1I2 1309.37416625355 1281.13688955476 1337.61144295234 1.044081591794 0.0622344585333092 0.655127486068293 1 8.70074 8.38371 9.63556 8.9817 GeneID:1781,Genbank:NM_001378.2,HGNC:HGNC:2964,MIM:603331 dynein cytoplasmic 1 intermediate chain 2 GO:0000086,GO:0003777,GO:0005737,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0006888,GO:0007018,GO:0007062,GO:0010389,GO:0010970,GO:0016032,GO:0019886,GO:0031982,GO:0045503,GO:0045504,GO:0097711,GO:2000582 G2/M transition of mitotic cell cycle|microtubule motor activity|cytoplasm|centrosome|cytosol|cytoplasmic dynein complex|microtubule|ER to Golgi vesicle-mediated transport|microtubule-based movement|sister chromatid cohesion|regulation of G2/M transition of mitotic cell cycle|transport along microtubule|viral process|antigen processing and presentation of exogenous peptide antigen via MHC class II|vesicle|dynein light chain binding|dynein heavy chain binding|ciliary basal body-plasma membrane docking|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed hsa04145,hsa04962,hsa05132 Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1LI1 1363.24205578183 1435.4200862745 1291.06402528915 0.899432882146705 -0.152912466781233 0.307254073270192 1 21.0692 19.8443 19.2907 17.3169 GeneID:51143,Genbank:NM_001329135.1,HGNC:HGNC:18745,MIM:615890 dynein cytoplasmic 1 light intermediate chain 1 GO:0000226,GO:0000776,GO:0000777,GO:0000922,GO:0003723,GO:0003777,GO:0005524,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0005886,GO:0006888,GO:0007018,GO:0007062,GO:0016020,GO:0016032,GO:0019003,GO:0019886,GO:0030667,GO:0043312,GO:0045504,GO:0051301,GO:0090267,GO:0101003 microtubule cytoskeleton organization|kinetochore|condensed chromosome kinetochore|spindle pole|RNA binding|microtubule motor activity|ATP binding|centrosome|cytosol|cytoplasmic dynein complex|microtubule|plasma membrane|ER to Golgi vesicle-mediated transport|microtubule-based movement|sister chromatid cohesion|membrane|viral process|GDP binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|secretory granule membrane|neutrophil degranulation|dynein heavy chain binding|cell division|positive regulation of mitotic cell cycle spindle assembly checkpoint|ficolin-1-rich granule membrane hsa04145,hsa04962,hsa05132 Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC1LI2 3041.50735253308 3120.22461321209 2962.79009185407 0.94954384992305 -0.0746934693353544 0.596842000285887 1 26.104 25.6419 27.8119 21.6826 GeneID:1783,Genbank:NM_001323955.1,HGNC:HGNC:2966,MIM:611406 dynein cytoplasmic 1 light intermediate chain 2 GO:0000226,GO:0000776,GO:0003777,GO:0005524,GO:0005764,GO:0005770,GO:0005813,GO:0005829,GO:0005868,GO:0005874,GO:0006888,GO:0007018,GO:0007062,GO:0016020,GO:0019886,GO:0045504,GO:0051260,GO:0051642,GO:1990090 microtubule cytoskeleton organization|kinetochore|microtubule motor activity|ATP binding|lysosome|late endosome|centrosome|cytosol|cytoplasmic dynein complex|microtubule|ER to Golgi vesicle-mediated transport|microtubule-based movement|sister chromatid cohesion|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|dynein heavy chain binding|protein homooligomerization|centrosome localization|cellular response to nerve growth factor stimulus hsa04145,hsa04962,hsa05132 Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC2H1 986.601894425348 1038.33611652693 934.867672323763 0.900351685204542 -0.151439454117056 0.325724925654878 1 2.35102 2.38756 2.21005 2.06691 GeneID:79659,Genbank:NM_001080463.1,HGNC:HGNC:2962,MIM:603297 dynein cytoplasmic 2 heavy chain 1 GO:0003774,GO:0003777,GO:0005524,GO:0005794,GO:0005868,GO:0005874,GO:0005886,GO:0005929,GO:0005930,GO:0007030,GO:0007275,GO:0016887,GO:0031514,GO:0035721,GO:0035735,GO:0045503,GO:0045505,GO:0051959,GO:0060271,GO:0070062,GO:0097542 motor activity|microtubule motor activity|ATP binding|Golgi apparatus|cytoplasmic dynein complex|microtubule|plasma membrane|cilium|axoneme|Golgi organization|multicellular organism development|ATPase activity|motile cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|dynein light chain binding|dynein intermediate chain binding|dynein light intermediate chain binding|cilium assembly|extracellular exosome|ciliary tip hsa04145,hsa04962,hsa05132 Phagosome|Vasopressin-regulated water reabsorption|Salmonella infection DYNC2LI1 75.8284639758921 82.3495788373432 69.3073491144411 0.841623601394937 -0.248752932631187 0.475807381296481 1 0.898995 0.833586 0.633548 0.611609 GeneID:51626,Genbank:NM_001348913.1,HGNC:HGNC:24595,MIM:617083 dynein cytoplasmic 2 light intermediate chain 1 GO:0003774,GO:0005737,GO:0005813,GO:0005868,GO:0005874,GO:0005929,GO:0005930,GO:0007368,GO:0030990,GO:0031514,GO:0035721,GO:0035735,GO:0035869,GO:0036064,GO:0045177,GO:0045504,GO:0097542,GO:1902017 motor activity|cytoplasm|centrosome|cytoplasmic dynein complex|microtubule|cilium|axoneme|determination of left/right symmetry|intraciliary transport particle|motile cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|apical part of cell|dynein heavy chain binding|ciliary tip|regulation of cilium assembly hsa04962 Vasopressin-regulated water reabsorption DYNLL1 5502.88064331013 5740.65050337115 5265.11078324912 0.917162746653402 -0.124750338213195 0.339369095403663 1 191.267 192.662 169.213 188.942 GeneID:8655,Genbank:NM_001037494.1,HGNC:HGNC:15476,MIM:601562 dynein light chain LC8-type 1 GO:0000776,GO:0003774,GO:0005634,GO:0005739,GO:0005868,GO:0005874,GO:0006351,GO:0006355,GO:0006915,GO:0007017,GO:0072686 kinetochore|motor activity|nucleus|mitochondrion|cytoplasmic dynein complex|microtubule|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|microtubule-based process|mitotic spindle hsa04962 Vasopressin-regulated water reabsorption DYNLL2 1793.71054208831 1812.28971803055 1775.13136614607 0.97949646156749 -0.0298878141231938 0.826236234815085 1 57.9145 61.1902 58.7347 59.5183 GeneID:140735,Genbank:NM_080677.2,HGNC:HGNC:24596,MIM:608942 dynein light chain LC8-type 2 GO:0003774,GO:0005634,GO:0005737,GO:0005813,GO:0005868,GO:0005874,GO:0010970,GO:0016020,GO:0016459,GO:0031475,GO:0042803,GO:0045505,GO:0046982,GO:0051959,GO:0060271,GO:0097110,GO:2000582 motor activity|nucleus|cytoplasm|centrosome|cytoplasmic dynein complex|microtubule|transport along microtubule|membrane|myosin complex|myosin V complex|protein homodimerization activity|dynein intermediate chain binding|protein heterodimerization activity|dynein light intermediate chain binding|cilium assembly|scaffold protein binding|positive regulation of ATP-dependent microtubule motor activity, plus-end-directed hsa04962 Vasopressin-regulated water reabsorption DYNLRB1 3388.06029457334 3226.7740551924 3549.34653395427 1.09996748245908 0.13746087503317 0.317827894486184 1 18.0964 19.8094 22.2852 22.3946 GeneID:83658,Genbank:NM_177953.2,HGNC:HGNC:15468,MIM:607167 dynein light chain roadblock-type 1 GO:0003777,GO:0005737,GO:0005813,GO:0005868,GO:0005874,GO:0005929,GO:0007018,GO:0007632,GO:0016020,GO:0035735,GO:0036157,GO:0045505,GO:0097542 microtubule motor activity|cytoplasm|centrosome|cytoplasmic dynein complex|microtubule|cilium|microtubule-based movement|visual behavior|membrane|intraciliary transport involved in cilium assembly|outer dynein arm|dynein intermediate chain binding|ciliary tip DYNLRB2 3.65974211013766 0.538097676642304 6.78138654363301 12.6025196502398 3.65564029873128 0.102294850878936 1 0 0 0.0410948 0.191851 GeneID:83657,Genbank:XM_011523370.2,HGNC:HGNC:15467,MIM:607168 dynein light chain roadblock-type 2 GO:0003777,GO:0005868,GO:0005874,GO:0005929,GO:0007018,GO:0035735,GO:0036157,GO:0045505,GO:0070062,GO:0097542 microtubule motor activity|cytoplasmic dynein complex|microtubule|cilium|microtubule-based movement|intraciliary transport involved in cilium assembly|outer dynein arm|dynein intermediate chain binding|extracellular exosome|ciliary tip DYNLT1 2698.49218862701 2725.36576276027 2671.61861449376 0.980278922924433 -0.0287357911023256 0.827516173686447 1 136.158 158.393 141.359 151.512 GeneID:6993,Genbank:NM_001291602.1,HGNC:HGNC:11697,MIM:601554 dynein light chain Tctex-type 1 GO:0000132,GO:0003774,GO:0005794,GO:0005819,GO:0005868,GO:0005874,GO:0006886,GO:0008277,GO:0043001,GO:0050768,GO:0051301 establishment of mitotic spindle orientation|motor activity|Golgi apparatus|spindle|cytoplasmic dynein complex|microtubule|intracellular protein transport|regulation of G-protein coupled receptor protein signaling pathway|Golgi to plasma membrane protein transport|negative regulation of neurogenesis|cell division DYNLT3 342.171537217828 357.687169493098 326.655904942559 0.913244680835167 -0.13092664920735 0.523446734185333 1 8.55607 7.50015 7.95462 6.87511 GeneID:6990,Genbank:NM_006520.2,HGNC:HGNC:11694,MIM:300302 dynein light chain Tctex-type 3 GO:0000777,GO:0003774,GO:0005634,GO:0005868,GO:0007049,GO:0007346,GO:0042802,GO:0045931,GO:0051301,GO:0061673 condensed chromosome kinetochore|motor activity|nucleus|cytoplasmic dynein complex|cell cycle|regulation of mitotic cell cycle|identical protein binding|positive regulation of mitotic cell cycle|cell division|mitotic spindle astral microtubule DYRK1A 651.713918762178 686.423942652845 617.003894871512 0.898867094418293 -0.153820278812091 0.36095539517352 1 2.19963 2.36415 2.40307 1.73971 GeneID:1859,Genbank:NM_001396.4,HGNC:HGNC:3091,MIM:600855 dual specificity tyrosine phosphorylation regulated kinase 1A DYRK1B 154.519422004427 138.94690443501 170.091939573844 1.22415062260996 0.291781081824001 0.238529592823316 1 1.72708 1.46858 1.8427 2.10128 GeneID:9149,Genbank:NM_006483.2,HGNC:HGNC:3092,MIM:604556 dual specificity tyrosine phosphorylation regulated kinase 1B DYRK2 384.333615930944 395.941147810241 372.726084051646 0.941367387837847 -0.0871702208484869 0.678362741204902 1 2.08387 1.94835 2.22828 1.61698 GeneID:8445,Genbank:NM_006482.2,HGNC:HGNC:3093,MIM:603496 dual specificity tyrosine phosphorylation regulated kinase 2 GO:0000151,GO:0000287,GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006974,GO:0007224,GO:0030145,GO:0030529,GO:0042771,GO:0045725,GO:0051534,GO:1901796 ubiquitin ligase complex|magnesium ion binding|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|cellular response to DNA damage stimulus|smoothened signaling pathway|manganese ion binding|intracellular ribonucleoprotein complex|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of glycogen biosynthetic process|negative regulation of NFAT protein import into nucleus|regulation of signal transduction by p53 class mediator DYRK3 445.977093114399 463.551383970142 428.402802258656 0.924175435718795 -0.113761351236247 0.515382071496551 1 2.15936 2.45209 2.17953 2.13451 GeneID:8444,Genbank:NM_001004023.1,HGNC:HGNC:3094,MIM:603497 dual specificity tyrosine phosphorylation regulated kinase 3 GO:0000287,GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0010494,GO:0030218,GO:0035617,GO:0043066,GO:0080135,GO:1903432 magnesium ion binding|protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|cytoplasmic stress granule|erythrocyte differentiation|stress granule disassembly|negative regulation of apoptotic process|regulation of cellular response to stress|regulation of TORC1 signaling DYRK4 245.84832415162 279.46988428037 212.22676402287 0.759390460154054 -0.397086219679223 0.167704190490713 1 3.56313 3.32956 2.07197 3.20953 GeneID:8798,Genbank:NM_003845.2,HGNC:HGNC:3095,MIM:609181 dual specificity tyrosine phosphorylation regulated kinase 4 GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005634,GO:0005737,GO:0043231,GO:0046872 protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|intracellular membrane-bounded organelle|metal ion binding DYSF 7.25844225171159 7.24520982488261 7.27167467854057 1.00365273805695 0.00526018587787087 1 1 0.035234 0.0177199 0.0375256 0.0131335 GeneID:8291,Genbank:XM_005264585.5,HGNC:HGNC:3097,MIM:603009 dysferlin DZANK1 44.7761361338608 43.0292138220232 46.5230584456985 1.08119703599806 0.112629461975299 0.787298987214677 1 0.22374 0.144672 0.170946 0.221876 GeneID:55184,Genbank:NM_001099407.1,HGNC:HGNC:15858 double zinc ribbon and ankyrin repeat domains 1 GO:0046872 metal ion binding DZIP1 343.103065324183 335.288980827969 350.917149820398 1.04661104267082 0.0657253858523741 0.74996489716248 1 1.21035 1.316 1.67288 1.07337 GeneID:22873,Genbank:NM_014934.4,HGNC:HGNC:20908,MIM:608671 DAZ interacting zinc finger protein 1 GO:0003676,GO:0005634,GO:0005654,GO:0005737,GO:0005814,GO:0005815,GO:0005829,GO:0007224,GO:0007275,GO:0007281,GO:0007283,GO:0036064,GO:0045184,GO:0046872,GO:0051220,GO:0060271,GO:0097539 nucleic acid binding|nucleus|nucleoplasm|cytoplasm|centriole|microtubule organizing center|cytosol|smoothened signaling pathway|multicellular organism development|germ cell development|spermatogenesis|ciliary basal body|establishment of protein localization|metal ion binding|cytoplasmic sequestering of protein|cilium assembly|ciliary transition fiber DZIP1L 101.458302181147 107.929344288496 94.987260073799 0.88008743775833 -0.184281230508176 0.517309668024044 1 0.16512 0.315885 0.244489 0.248469 GeneID:199221,Genbank:NM_173543.2,HGNC:HGNC:26551,MIM:617570 DAZ interacting zinc finger protein 1 like GO:0003676,GO:0005814,GO:0032880,GO:0036064,GO:0046872,GO:0060271 nucleic acid binding|centriole|regulation of protein localization|ciliary basal body|metal ion binding|cilium assembly DZIP3 120.921416730972 108.543877204292 133.298956257651 1.22806518148202 0.296387136038098 0.389708481594211 1 0.520943 0.473731 0.852692 0.504058 GeneID:9666,Genbank:NM_014648.3,HGNC:HGNC:30938,MIM:608672 DAZ interacting zinc finger protein 3 GO:0000209,GO:0000836,GO:0003723,GO:0004842,GO:0005737,GO:0019902,GO:0030433,GO:0030968,GO:0031593,GO:0036513,GO:0042787,GO:0044322,GO:0046872,GO:0051082,GO:1904264,GO:1990381 protein polyubiquitination|Hrd1p ubiquitin ligase complex|RNA binding|ubiquitin-protein transferase activity|cytoplasm|phosphatase binding|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|polyubiquitin modification-dependent protein binding|Derlin-1 retrotranslocation complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|endoplasmic reticulum quality control compartment|metal ion binding|unfolded protein binding|ubiquitin protein ligase activity involved in ERAD pathway|ubiquitin-specific protease binding E2F1 3271.98623596807 2937.033305782 3606.93916615413 1.22808929645208 0.29641546532115 0.0312150286728188 0.700195937288327 44.6104 47.8826 56.7522 60.0693 GeneID:1869,Genbank:NM_005225.2,HGNC:HGNC:3113,MIM:189971 E2F transcription factor 1 hsa01522,hsa04110,hsa04137,hsa04218,hsa04934,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05206,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 Endocrine resistance|Cell cycle|Mitophagy - animal|Cellular senescence|Cushing syndrome|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer E2F2 916.929169297898 923.268440618886 910.58989797691 0.986267761266184 -0.0199487186612245 0.888167285194136 1 5.99871 6.33158 6.17757 6.31861 GeneID:1870,Genbank:XM_011540870.3,HGNC:HGNC:3114,MIM:600426 E2F transcription factor 2 hsa01522,hsa04110,hsa04218,hsa04934,hsa05161,hsa05163,hsa05166,hsa05167,hsa05169,hsa05200,hsa05206,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 Endocrine resistance|Cell cycle|Cellular senescence|Cushing syndrome|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer E2F3 1028.86880740591 1111.72033130499 946.017283506841 0.850948981383081 -0.232855457114843 0.128147958806707 1 5.23262 5.13067 4.67692 4.28035 GeneID:1871,Genbank:NM_001949.4,HGNC:HGNC:3115,MIM:600427 E2F transcription factor 3 hsa01522,hsa04110,hsa04218,hsa04934,hsa05161,hsa05163,hsa05166,hsa05167,hsa05169,hsa05200,hsa05206,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 Endocrine resistance|Cell cycle|Cellular senescence|Cushing syndrome|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer E2F4 1631.73544711098 1714.6332728738 1548.83762134817 0.903305474034254 -0.146714143340256 0.297518214805241 1 30.923 32.085 28.6351 28.9927 GeneID:1874,Genbank:NM_001950.3,HGNC:HGNC:3118,MIM:600659 E2F transcription factor 4 hsa04110,hsa04218,hsa04350 Cell cycle|Cellular senescence|TGF-beta signaling pathway E2F5 548.380456690587 600.508576831998 496.252336549175 0.826386758982145 -0.275110956492515 0.110070527119488 1 11.3052 11.0802 9.46337 9.18467 GeneID:1875,Genbank:NM_001951.3,HGNC:HGNC:3119,MIM:600967 E2F transcription factor 5 hsa04110,hsa04218,hsa04350 Cell cycle|Cellular senescence|TGF-beta signaling pathway E2F6 407.155060638753 427.084186471449 387.225934806057 0.906673548382348 -0.141344899047665 0.453177854556161 1 2.85161 2.73064 2.6556 2.20762 GeneID:1876,Genbank:NM_001278278.1,HGNC:HGNC:3120,MIM:602944 E2F transcription factor 6 E2F7 931.86670549228 917.578671893283 946.154739091278 1.03114290694991 0.0442442908637028 0.864074376064474 1 5.88199 5.82935 7.56768 4.90557 GeneID:144455,Genbank:NM_203394.2,HGNC:HGNC:23820,MIM:612046 E2F transcription factor 7 GO:0000122,GO:0000977,GO:0001047,GO:0001227,GO:0001890,GO:0002040,GO:0003700,GO:0003714,GO:0005654,GO:0005667,GO:0006351,GO:0006977,GO:0008285,GO:0016607,GO:0030330,GO:0032466,GO:0032877,GO:0042802,GO:0045944,GO:0060707,GO:0060718,GO:0070365,GO:0071930,GO:2000134 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|placenta development|sprouting angiogenesis|DNA binding transcription factor activity|transcription corepressor activity|nucleoplasm|transcription factor complex|transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation|nuclear speck|DNA damage response, signal transduction by p53 class mediator|negative regulation of cytokinesis|positive regulation of DNA endoreduplication|identical protein binding|positive regulation of transcription from RNA polymerase II promoter|trophoblast giant cell differentiation|chorionic trophoblast cell differentiation|hepatocyte differentiation|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of G1/S transition of mitotic cell cycle E2F8 338.266150898033 360.061091263731 316.471210532335 0.878937542019868 -0.186167444899446 0.341982050595286 1 2.79772 2.70489 2.484 2.32054 GeneID:79733,Genbank:NM_001256372.1,HGNC:HGNC:24727,MIM:612047 E2F transcription factor 8 GO:0000122,GO:0000978,GO:0001047,GO:0001078,GO:0001890,GO:0002040,GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0006351,GO:0006977,GO:0008283,GO:0032466,GO:0032877,GO:0033301,GO:0042803,GO:0045944,GO:0060707,GO:0060718,GO:0070365 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|core promoter binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|placenta development|sprouting angiogenesis|DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|transcription factor complex|nucleolus|cytosol|transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|cell proliferation|negative regulation of cytokinesis|positive regulation of DNA endoreduplication|cell cycle comprising mitosis without cytokinesis|protein homodimerization activity|positive regulation of transcription from RNA polymerase II promoter|trophoblast giant cell differentiation|chorionic trophoblast cell differentiation|hepatocyte differentiation E4F1 482.2270668242 506.494353897903 457.959779750497 0.904175488287499 -0.145325287389062 0.398455036375493 1 6.5194 6.95441 5.7985 5.89958 GeneID:1877,Genbank:NM_004424.4,HGNC:HGNC:3121,MIM:603022 E4F transcription factor 1 GO:0000122,GO:0000977,GO:0001227,GO:0003677,GO:0003700,GO:0003713,GO:0003714,GO:0005654,GO:0005737,GO:0005819,GO:0006260,GO:0006351,GO:0008283,GO:0009794,GO:0010564,GO:0016032,GO:0016567,GO:0016740,GO:0035497,GO:0040008,GO:0046872,GO:0051301,GO:0071850 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|nucleoplasm|cytoplasm|spindle|DNA replication|transcription, DNA-templated|cell proliferation|regulation of mitotic cell cycle, embryonic|regulation of cell cycle process|viral process|protein ubiquitination|transferase activity|cAMP response element binding|regulation of growth|metal ion binding|cell division|mitotic cell cycle arrest EAF1 1065.55038595627 1075.01300243287 1056.08776947967 0.982395345069903 -0.0256243701528827 0.889065569434361 1 8.74846 7.90216 9.33229 7.46581 GeneID:85403,Genbank:NM_033083.6,HGNC:HGNC:20907,MIM:608315 ELL associated factor 1 GO:0005654,GO:0006355,GO:0006366,GO:0006368,GO:0008023,GO:0015030,GO:0016604,GO:0016607,GO:0032783,GO:0043231,GO:0045171 nucleoplasm|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|Cajal body|nuclear body|nuclear speck|ELL-EAF complex|intracellular membrane-bounded organelle|intercellular bridge EAF2 17.5044692177989 20.4673290226234 14.5416094129743 0.710479095582079 -0.493135893193751 0.482913468400385 1 0.111045 0.140317 0.0784537 0.0549655 GeneID:55840,Genbank:XM_005247618.3,HGNC:HGNC:23115,MIM:607659 ELL associated factor 2 GO:0000977,GO:0001228,GO:0005654,GO:0006366,GO:0006368,GO:0006915,GO:0008023,GO:0016607,GO:0030308,GO:0032783,GO:0045944,GO:0060770 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleoplasm|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|apoptotic process|transcription elongation factor complex|nuclear speck|negative regulation of cell growth|ELL-EAF complex|positive regulation of transcription from RNA polymerase II promoter|negative regulation of epithelial cell proliferation involved in prostate gland development EAPP 321.925783434719 312.861366197516 330.990200671921 1.05794526404695 0.0812649872527026 0.675770829667055 1 3.3012 3.01148 3.09292 3.33885 GeneID:55837,Genbank:NM_001318916.1,HGNC:HGNC:19312,MIM:609486 E2F associated phosphoprotein GO:0005634,GO:0005737,GO:0008284,GO:0032968,GO:0034244 nucleus|cytoplasm|positive regulation of cell proliferation|positive regulation of transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter EARS2 1022.2934324206 1019.15670526655 1025.43015957465 1.00615553454702 0.00885333851861508 0.957561938738086 1 7.49285 7.63518 7.5606 8.26563 GeneID:124454,Genbank:NM_001083614.1,HGNC:HGNC:29419,MIM:612799 glutamyl-tRNA synthetase 2, mitochondrial GO:0000049,GO:0004818,GO:0005524,GO:0005739,GO:0005759,GO:0006424,GO:0008270,GO:0050561,GO:0070127 tRNA binding|glutamate-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|glutamyl-tRNA aminoacylation|zinc ion binding|glutamate-tRNA(Gln) ligase activity|tRNA aminoacylation for mitochondrial protein translation hsa00860,hsa00970 Porphyrin and chlorophyll metabolism|Aminoacyl-tRNA biosynthesis EBAG9 187.702095207527 182.043761841934 193.360428573121 1.06216454009016 0.087007271589126 0.719751311319008 1 2.39266 2.56483 2.6209 2.5993 GeneID:9166,Genbank:NM_198120.2,HGNC:HGNC:3123,MIM:605772 estrogen receptor binding site associated, antigen, 9 hsa04915 Estrogen signaling pathway EBF1 68.250771681041 74.4702187864484 62.0313245756335 0.832968206438539 -0.263666664469188 0.465037027536946 1 0.045933 0.0407126 0.0380022 0.0354198 GeneID:1879,Genbank:NM_182708.2,HGNC:HGNC:3126,MIM:164343 early B cell factor 1 GO:0000978,GO:0001077,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0006355,GO:0007275,GO:0045893,GO:0045944,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|multicellular organism development|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding EBF2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00834166 0 0 0 GeneID:64641,Genbank:NM_022659.3,HGNC:HGNC:19090,MIM:609934 early B cell factor 2 GO:0000978,GO:0001077,GO:0001709,GO:0003682,GO:0005634,GO:0035563,GO:0046872,GO:0050873,GO:0060612 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|cell fate determination|chromatin binding|nucleus|positive regulation of chromatin binding|metal ion binding|brown fat cell differentiation|adipose tissue development EBF4 138.189247098471 130.991109144961 145.387385051981 1.10990269493091 0.150433201175321 0.598251666156117 1 1.69524 2.06402 2.16485 2.01959 GeneID:57593,Genbank:NM_001110514.1,HGNC:HGNC:29278,MIM:609935 early B cell factor 4 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0007275,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|metal ion binding EBI3 12.4833010473199 19.1510022959141 5.81559979872566 0.303670779673313 -1.71942000116152 0.0626151028900384 0.892209508796134 0.430621 0.956602 0.196841 0.221956 GeneID:10148,Genbank:XM_011527619.2,HGNC:HGNC:3129,MIM:605816 Epstein-Barr virus induced 3 EBLN2 12.3681919381441 11.1657810405415 13.5706028357466 1.21537425697974 0.281400639384132 0.787604726344105 1 0.208128 0.319828 0.223507 0.299884 GeneID:55096,Genbank:NM_018029.4,HGNC:HGNC:25493,MIM:613250 endogenous Bornavirus like nucleoprotein 2 EBNA1BP2 2119.0621045957 2275.40886552853 1962.71534366287 0.862576995896063 -0.213274853599566 0.123194149935036 1 42.7343 46.0111 39.0448 38.5165 GeneID:10969,Genbank:NM_001159936.1,HGNC:HGNC:15531,MIM:614443 EBNA1 binding protein 2 GO:0003723,GO:0005634,GO:0005730,GO:0006364,GO:0030687,GO:0034399,GO:0042273 RNA binding|nucleus|nucleolus|rRNA processing|preribosome, large subunit precursor|nuclear periphery|ribosomal large subunit biogenesis EBP 1448.30122170601 1394.81383749865 1501.78860591337 1.07669465669093 0.106609169347567 0.468103176238074 1 58.5875 57.864 61.977 64.4673 GeneID:10682,Genbank:NM_006579.2,HGNC:HGNC:3133,MIM:300205 emopamil binding protein (sterol isomerase) GO:0000247,GO:0001501,GO:0004769,GO:0004888,GO:0005635,GO:0005783,GO:0005789,GO:0005887,GO:0006695,GO:0008203,GO:0015238,GO:0030097,GO:0031410,GO:0033489,GO:0033490,GO:0047750 C-8 sterol isomerase activity|skeletal system development|steroid delta-isomerase activity|transmembrane signaling receptor activity|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|cholesterol biosynthetic process|cholesterol metabolic process|drug transmembrane transporter activity|hemopoiesis|cytoplasmic vesicle|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|cholestenol delta-isomerase activity hsa00100 Steroid biosynthesis EBPL 510.116016761359 583.164989665605 437.067043857113 0.749474079552912 -0.41604951124007 0.07837582138448 0.942392759229604 22.0924 24.8107 15.1807 20.1291 GeneID:84650,Genbank:NM_032565.4,HGNC:HGNC:18061,MIM:617335 emopamil binding protein like GO:0005783,GO:0005789,GO:0016021,GO:0016125,GO:0047750 endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|sterol metabolic process|cholestenol delta-isomerase activity ECD 905.771090096124 933.856889362354 877.685290829895 0.939849885809791 -0.0894977490462555 0.567591369502531 1 11.4121 11.1329 10.8926 10.1199 GeneID:11319,Genbank:NM_001135753.1,HGNC:HGNC:17029,MIM:616464 ecdysoneless cell cycle regulator GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006110,GO:0006366,GO:0006397,GO:0008283,GO:0008380,GO:0035035,GO:0045944,GO:2000045 transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of glycolytic process|transcription from RNA polymerase II promoter|mRNA processing|cell proliferation|RNA splicing|histone acetyltransferase binding|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle ECE1 3290.71719919311 3055.44422060863 3525.9901777776 1.15400247008117 0.206646311999034 0.131317821728602 1 13.9526 14.2396 16.039 17.3397 GeneID:1889,Genbank:NM_001113348.1,HGNC:HGNC:3146,MIM:600423 endothelin converting enzyme 1 ECEL1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.016624 GeneID:9427,Genbank:NM_001290787.1,HGNC:HGNC:3147,MIM:605896 endothelin converting enzyme like 1 GO:0003016,GO:0004222,GO:0005887,GO:0007218,GO:0008237,GO:0046872 respiratory system process|metalloendopeptidase activity|integral component of plasma membrane|neuropeptide signaling pathway|metallopeptidase activity|metal ion binding ECH1 2187.25776347897 2050.91322216164 2323.6023047963 1.13295983452057 0.180096715911177 0.325637441422134 1 39.6202 43.4314 44.7215 51.9242 GeneID:1891,Genbank:NM_001398.2,HGNC:HGNC:3149,MIM:600696 enoyl-CoA hydratase 1 GO:0005102,GO:0005739,GO:0005777,GO:0006635,GO:0016020,GO:0016853,GO:0070062 receptor binding|mitochondrion|peroxisome|fatty acid beta-oxidation|membrane|isomerase activity|extracellular exosome hsa04146 Peroxisome ECHDC1 1032.77869219273 1071.51485903427 994.042525351185 0.92769831138608 -0.108272379438147 0.505524565457773 1 8.8129 7.39887 8.85548 6.84646 GeneID:55862,Genbank:XM_011535942.3,HGNC:HGNC:21489,MIM:612136 ethylmalonyl-CoA decarboxylase 1 GO:0004300,GO:0004492,GO:0005739,GO:0005829,GO:0006635,GO:0016831,GO:0070062 enoyl-CoA hydratase activity|methylmalonyl-CoA decarboxylase activity|mitochondrion|cytosol|fatty acid beta-oxidation|carboxy-lyase activity|extracellular exosome hsa00640 Propanoate metabolism ECHDC2 28.2124942806109 24.9259979149246 31.4989906462972 1.2637002840892 0.337654335405184 0.560566583380866 1 0.0854651 0.0953431 0.127371 0.113485 GeneID:55268,Genbank:NM_001319958.1,HGNC:HGNC:23408 enoyl-CoA hydratase domain containing 2 GO:0004300,GO:0005739,GO:0006635 enoyl-CoA hydratase activity|mitochondrion|fatty acid beta-oxidation ECHS1 3615.36827044346 3543.89421053008 3686.84233035685 1.0403364523134 0.0570501818134349 0.695616479097503 1 98.8191 108.517 103.877 112.428 GeneID:1892,Genbank:NM_004092.3,HGNC:HGNC:3151,MIM:602292 enoyl-CoA hydratase, short chain 1 GO:0004300,GO:0005739,GO:0005759,GO:0006635,GO:0070062 enoyl-CoA hydratase activity|mitochondrion|mitochondrial matrix|fatty acid beta-oxidation|extracellular exosome hsa00062,hsa00071,hsa00280,hsa00310,hsa00380,hsa00410,hsa00640,hsa00650 Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism ECI1 982.428184397726 865.365613950473 1099.49075484498 1.27055054779182 0.345453772949661 0.235370587336405 1 34.6358 39.4174 41.0051 52.9907 GeneID:1632,Genbank:NM_001178029.1,HGNC:HGNC:2703,MIM:600305 enoyl-CoA delta isomerase 1 GO:0004165,GO:0004300,GO:0005739,GO:0005743,GO:0005759,GO:0006635,GO:0016860,GO:0070062 dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|fatty acid beta-oxidation|intramolecular oxidoreductase activity|extracellular exosome hsa00071 Fatty acid degradation ECI2 1085.0410299147 1134.92617498551 1035.15588484389 0.912090942705682 -0.132750415180125 0.385866887808811 1 24.091 23.6974 22.8776 21.3266 GeneID:10455,Genbank:NM_006117.2,HGNC:HGNC:14601,MIM:608024 enoyl-CoA delta isomerase 2 GO:0000062,GO:0004165,GO:0005102,GO:0005654,GO:0005739,GO:0005777,GO:0005782,GO:0009062,GO:0016020,GO:0033540,GO:0043231 fatty-acyl-CoA binding|dodecenoyl-CoA delta-isomerase activity|receptor binding|nucleoplasm|mitochondrion|peroxisome|peroxisomal matrix|fatty acid catabolic process|membrane|fatty acid beta-oxidation using acyl-CoA oxidase|intracellular membrane-bounded organelle hsa00071,hsa04146 Fatty acid degradation|Peroxisome ECM1 597.884663897469 588.545966432028 607.223361362909 1.03173481086636 0.0450721992375312 0.802148418101745 1 7.73441 8.23686 8.3913 8.37783 GeneID:1893,Genbank:NM_004425.3,HGNC:HGNC:3153,MIM:602201 extracellular matrix protein 1 ECM2 6.40152951795639 5.53486424558581 7.26819479032697 1.3131658642077 0.393049152603213 0.814729348765791 1 0.0160827 0.0620788 0.0309533 0.0577169 GeneID:1842,Genbank:NM_001197296.1,HGNC:HGNC:3154,MIM:603479 extracellular matrix protein 2 GO:0005178,GO:0005578,GO:0005614,GO:0005615,GO:0007160,GO:0008201,GO:0010811,GO:0030198,GO:0070052 integrin binding|proteinaceous extracellular matrix|interstitial matrix|extracellular space|cell-matrix adhesion|heparin binding|positive regulation of cell-substrate adhesion|extracellular matrix organization|collagen V binding ECPAS 1540.31559060774 1595.1234943811 1485.50768683439 0.931280676428601 -0.102712051201042 0.482488144411675 1 6.27786 6.23675 6.68609 5.37606 GeneID:23392,Genbank:NM_001080398.1,HGNC:HGNC:29020,MIM:616694 Ecm29 proteasome adaptor and scaffold GO:0000502,GO:0005634,GO:0005769,GO:0005770,GO:0005771,GO:0005783,GO:0005793,GO:0005813,GO:0016020,GO:0030134,GO:0030139,GO:0030433,GO:0031410,GO:0032947,GO:0043248 proteasome complex|nucleus|early endosome|late endosome|multivesicular body|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|centrosome|membrane|COPII-coated ER to Golgi transport vesicle|endocytic vesicle|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle|protein complex scaffold activity|proteasome assembly ECSCR 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0386464 0 0 0 GeneID:641700,Genbank:NM_001293739.1,HGNC:HGNC:35454,MIM:615736 endothelial cell surface expressed chemotaxis and apoptosis regulator GO:0001525,GO:0005654,GO:0005829,GO:0005886,GO:0006915,GO:0006935,GO:0016021,GO:0016525,GO:0030154,GO:0043231,GO:1901800,GO:2000353 angiogenesis|nucleoplasm|cytosol|plasma membrane|apoptotic process|chemotaxis|integral component of membrane|negative regulation of angiogenesis|cell differentiation|intracellular membrane-bounded organelle|positive regulation of proteasomal protein catabolic process|positive regulation of endothelial cell apoptotic process ECSIT 600.365015482497 593.984778128244 606.745252836749 1.02148283117408 0.0306649558203671 0.87182747284696 1 11.3174 11.4733 11.4675 10.9997 GeneID:51295,Genbank:NM_001142465.2,HGNC:HGNC:29548,MIM:608388 ECSIT signalling integrator GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005829,GO:0016651,GO:0032981,GO:0045087,GO:0051341 nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|cytosol|oxidoreductase activity, acting on NAD(P)H|mitochondrial respiratory chain complex I assembly|innate immune response|regulation of oxidoreductase activity hsa04010 MAPK signaling pathway ECT2 1662.23876323072 1803.50156541062 1520.97596105083 0.843346072008832 -0.245803323842871 0.417668617461682 1 12.294 10.0053 11.2523 7.55303 GeneID:1894,Genbank:NM_001349098.1,HGNC:HGNC:3155,MIM:600586 epithelial cell transforming 2 EDA 4.0159480250719 3.67063118712625 4.36126486301754 1.18815120361684 0.248718444579199 0.943017848354346 1 0.0150231 0.00705236 0.0143597 0.0134017 GeneID:1896,Genbank:NM_001399.4,HGNC:HGNC:3157,MIM:300451 ectodysplasin A GO:0005102,GO:0005123,GO:0005164,GO:0005576,GO:0005581,GO:0005789,GO:0005811,GO:0005856,GO:0005886,GO:0005887,GO:0006955,GO:0007160,GO:0010467,GO:0010628,GO:0016020,GO:0016021,GO:0019221,GO:0030154,GO:0033209,GO:0038177,GO:0042346,GO:0042475,GO:0043231,GO:0043473,GO:0045177,GO:0051092,GO:0060662,GO:0060789,GO:0061153,GO:0090263,GO:1901222 receptor binding|death receptor binding|tumor necrosis factor receptor binding|extracellular region|collagen trimer|endoplasmic reticulum membrane|lipid droplet|cytoskeleton|plasma membrane|integral component of plasma membrane|immune response|cell-matrix adhesion|gene expression|positive regulation of gene expression|membrane|integral component of membrane|cytokine-mediated signaling pathway|cell differentiation|tumor necrosis factor-mediated signaling pathway|death receptor agonist activity|positive regulation of NF-kappaB import into nucleus|odontogenesis of dentin-containing tooth|intracellular membrane-bounded organelle|pigmentation|apical part of cell|positive regulation of NF-kappaB transcription factor activity|salivary gland cavitation|hair follicle placode formation|trachea gland development|positive regulation of canonical Wnt signaling pathway|regulation of NIK/NF-kappaB signaling hsa04060 Cytokine-cytokine receptor interaction EDA2R 76.8426846489952 70.7995875993222 82.8857816986683 1.17070995056844 0.227383684968781 0.505101763931703 1 0.502328 0.554989 0.720872 0.471849 GeneID:60401,Genbank:XM_011531005.2,HGNC:HGNC:17756,MIM:300276 ectodysplasin A2 receptor GO:0004872,GO:0005031,GO:0005622,GO:0005886,GO:0005887,GO:0007275,GO:0008544,GO:0009888,GO:0010668,GO:0016021,GO:0033209,GO:0043123,GO:0046330,GO:0051092,GO:0072332 receptor activity|tumor necrosis factor-activated receptor activity|intracellular|plasma membrane|integral component of plasma membrane|multicellular organism development|epidermis development|tissue development|ectodermal cell differentiation|integral component of membrane|tumor necrosis factor-mediated signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|intrinsic apoptotic signaling pathway by p53 class mediator hsa04060 Cytokine-cytokine receptor interaction EDARADD 120.243171050962 115.942974508338 124.543367593587 1.07417778543047 0.10323279121166 0.720094214998172 1 1.38301 1.39149 1.44273 1.52654 GeneID:128178,Genbank:NM_145861.2,HGNC:HGNC:14341,MIM:606603 EDAR associated death domain EDC3 1272.58693635285 1197.95328073927 1347.22059196643 1.12460194702672 0.169414449735762 0.257864127205077 1 8.07544 8.57563 9.40241 9.80036 GeneID:80153,Genbank:NM_001351379.1,HGNC:HGNC:26114,MIM:609842 enhancer of mRNA decapping 3 GO:0000932,GO:0003729,GO:0005829,GO:0016020,GO:0031087,GO:0033962,GO:0036464,GO:0042802,GO:0043928,GO:1990174 P-body|mRNA binding|cytosol|membrane|deadenylation-independent decapping of nuclear-transcribed mRNA|cytoplasmic mRNA processing body assembly|cytoplasmic ribonucleoprotein granule|identical protein binding|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|phosphodiesterase decapping endonuclease activity hsa03018 RNA degradation EDC4 2131.55772758936 2214.6126197222 2048.50283545652 0.92499375159954 -0.112484474736038 0.409470602417639 1 19.1382 19.7771 18.7708 18.0266 GeneID:23644,Genbank:NM_014329.4,HGNC:HGNC:17157,MIM:606030 enhancer of mRNA decapping 4 GO:0000932,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016020,GO:0031087,GO:0036464,GO:0043928 P-body|nucleus|nucleoplasm|cytoplasm|cytosol|membrane|deadenylation-independent decapping of nuclear-transcribed mRNA|cytoplasmic ribonucleoprotein granule|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay hsa03018 RNA degradation EDEM1 2206.40257166703 2340.76760742992 2072.03753590414 0.885195749175272 -0.175931571740395 0.306288040697613 1 15.158 15.289 15.8202 11.5091 GeneID:9695,Genbank:NM_014674.2,HGNC:HGNC:18967,MIM:607673 ER degradation enhancing alpha-mannosidase like protein 1 GO:0000139,GO:0004571,GO:0005509,GO:0005783,GO:0006491,GO:0016235,GO:0030176,GO:0030433,GO:0036498,GO:0036510,GO:0044322,GO:0051787,GO:0097466,GO:1904154,GO:1904382 Golgi membrane|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|N-glycan processing|aggresome|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|IRE1-mediated unfolded protein response|trimming of terminal mannose on C branch|endoplasmic reticulum quality control compartment|misfolded protein binding|ubiquitin-dependent glycoprotein ERAD pathway|positive regulation of retrograde protein transport, ER to cytosol|mannose trimming involved in glycoprotein ERAD pathway hsa04141 Protein processing in endoplasmic reticulum EDEM2 18.2417287500147 18.5550696894789 17.9283878105506 0.966225840731618 -0.0495676581835675 0.996310224922529 1 11.757 12.0037 14.0741 13.4951 GeneID:55741,Genbank:NM_001145025.1,HGNC:HGNC:15877,MIM:610302 ER degradation enhancing alpha-mannosidase like protein 2 GO:0004571,GO:0005509,GO:0005783,GO:0005788,GO:0006491,GO:0016020,GO:0030968,GO:0036509,GO:0036510,GO:0036511,GO:0036512,GO:0044322,GO:0097466,GO:1904154,GO:1904382 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum lumen|N-glycan processing|membrane|endoplasmic reticulum unfolded protein response|trimming of terminal mannose on B branch|trimming of terminal mannose on C branch|trimming of first mannose on A branch|trimming of second mannose on A branch|endoplasmic reticulum quality control compartment|ubiquitin-dependent glycoprotein ERAD pathway|positive regulation of retrograde protein transport, ER to cytosol|mannose trimming involved in glycoprotein ERAD pathway hsa04141 Protein processing in endoplasmic reticulum EDEM3 395.279149190905 425.546328680676 365.011969701134 0.857749074778258 -0.2213724302846 0.564178587380888 1 2.12418 1.91532 2.26738 1.20653 GeneID:80267,Genbank:NM_025191.3,HGNC:HGNC:16787,MIM:610214 ER degradation enhancing alpha-mannosidase like protein 3 GO:0004571,GO:0005509,GO:0005783,GO:0005788,GO:0006486,GO:0006491,GO:0016020,GO:0030968,GO:0044322,GO:1904382 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum lumen|protein glycosylation|N-glycan processing|membrane|endoplasmic reticulum unfolded protein response|endoplasmic reticulum quality control compartment|mannose trimming involved in glycoprotein ERAD pathway hsa04141 Protein processing in endoplasmic reticulum EDF1 5124.86127084278 5213.49874935359 5036.22379233198 0.965996931131212 -0.0499094891066607 0.781281090617384 1 130.799 139.446 121.839 144.176 GeneID:8721,Genbank:NM_001281298.1,HGNC:HGNC:3164,MIM:605107 endothelial differentiation related factor 1 GO:0003713,GO:0003723,GO:0005516,GO:0005622,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0007275,GO:0019216,GO:0043388,GO:0043565,GO:0045446,GO:0045893,GO:0070062 transcription coactivator activity|RNA binding|calmodulin binding|intracellular|nucleus|nucleolus|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|regulation of lipid metabolic process|positive regulation of DNA binding|sequence-specific DNA binding|endothelial cell differentiation|positive regulation of transcription, DNA-templated|extracellular exosome EDIL3 3273.96682661135 3651.51440150595 2896.41925171676 0.793210414430302 -0.3342244753787 0.124310447836569 1 37.5301 31.5379 31.3634 23.8079 GeneID:10085,Genbank:NM_001278642.1,HGNC:HGNC:3173,MIM:606018 EGF like repeats and discoidin domains 3 GO:0005178,GO:0005509,GO:0007155,GO:0007275,GO:0010811,GO:0031012,GO:0070062,GO:1903561 integrin binding|calcium ion binding|cell adhesion|multicellular organism development|positive regulation of cell-substrate adhesion|extracellular matrix|extracellular exosome|extracellular vesicle EDN1 227.143376067092 290.971849243706 163.314902890478 0.561273894072456 -0.833223136546138 0.000153274135771259 0.0299370555916156 4.00756 3.64363 2.18102 2.16652 GeneID:1906,Genbank:XM_011514331.3,HGNC:HGNC:3176,MIM:131240 endothelin 1 hsa04066,hsa04270,hsa04668,hsa04916,hsa04926,hsa04933,hsa05410,hsa05418 HIF-1 signaling pathway|Vascular smooth muscle contraction|TNF signaling pathway|Melanogenesis|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Hypertrophic cardiomyopathy (HCM)|Fluid shear stress and atherosclerosis EDN2 1.02273099320278 1.07619535328461 0.969266633120943 0.900641904987498 -0.150974490057726 1 1 0.0910652 0 0.0419828 0.03919 GeneID:1907,Genbank:XM_017000512.1,HGNC:HGNC:3177,MIM:131241 endothelin 2 hsa04080,hsa04270 Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction EDNRA 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0.00867788 0.0161642 GeneID:1909,Genbank:NM_001957.3,HGNC:HGNC:3179,MIM:131243 endothelin receptor type A hsa04020,hsa04022,hsa04024,hsa04080,hsa04270,hsa04924,hsa05200 Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Vascular smooth muscle contraction|Renin secretion|Pathways in cancer EDNRB 380.724305374173 286.513180351404 474.935430396942 1.65763903012922 0.729129877677984 9.29179443596012e-05 0.0218849087774025 2.66049 2.47805 4.40417 4.2409 GeneID:1910,Genbank:NM_000115.4,HGNC:HGNC:3180,MIM:131244 endothelin receptor type B hsa04020,hsa04022,hsa04080,hsa04916,hsa04926,hsa05200 Calcium signaling pathway|cGMP-PKG signaling pathway|Neuroactive ligand-receptor interaction|Melanogenesis|Relaxin signaling pathway|Pathways in cancer EDRF1 326.664498254885 358.139023275479 295.189973234291 0.824232920876741 -0.278876007103574 0.298696417680835 1 2.85608 2.60432 2.7651 1.74706 GeneID:26098,Genbank:NM_001202438.1,HGNC:HGNC:24640 erythroid differentiation regulatory factor 1 GO:0005634,GO:0006351,GO:0045893 nucleus|transcription, DNA-templated|positive regulation of transcription, DNA-templated EEA1 74.6801682624253 64.5247119232463 84.8356246016043 1.31477727018012 0.394818420488971 0.487677306408402 1 0.289156 0.204307 0.434464 0.194132 GeneID:8411,Genbank:XM_017020018.1,HGNC:HGNC:3185,MIM:605070 early endosome antigen 1 GO:0003676,GO:0005516,GO:0005545,GO:0005737,GO:0005769,GO:0005829,GO:0005969,GO:0006897,GO:0006906,GO:0008270,GO:0016020,GO:0016189,GO:0019897,GO:0030742,GO:0031901,GO:0039694,GO:0042803,GO:0044308,GO:0045022,GO:0055037,GO:0070062,GO:0098793 nucleic acid binding|calmodulin binding|1-phosphatidylinositol binding|cytoplasm|early endosome|cytosol|serine-pyruvate aminotransferase complex|endocytosis|vesicle fusion|zinc ion binding|membrane|synaptic vesicle to endosome fusion|extrinsic component of plasma membrane|GTP-dependent protein binding|early endosome membrane|viral RNA genome replication|protein homodimerization activity|axonal spine|early endosome to late endosome transport|recycling endosome|extracellular exosome|presynapse hsa04144,hsa04145,hsa05152 Endocytosis|Phagosome|Tuberculosis EED 371.694969007969 406.050350807714 337.339587208224 0.830782651799682 -0.267457004395559 0.153877199605797 1 2.92625 2.87075 2.88413 1.95862 GeneID:8726,Genbank:NM_001308007.1,HGNC:HGNC:3188,MIM:605984 embryonic ectoderm development GO:0000122,GO:0000978,GO:0001739,GO:0003682,GO:0005634,GO:0005654,GO:0005829,GO:0006349,GO:0006351,GO:0016571,GO:0021510,GO:0035098,GO:0042054,GO:0042802,GO:0045120,GO:0046976,GO:0061087,GO:1990830,GO:2000011 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|sex chromatin|chromatin binding|nucleus|nucleoplasm|cytosol|regulation of gene expression by genetic imprinting|transcription, DNA-templated|histone methylation|spinal cord development|ESC/E(Z) complex|histone methyltransferase activity|identical protein binding|pronucleus|histone methyltransferase activity (H3-K27 specific)|positive regulation of histone H3-K27 methylation|cellular response to leukemia inhibitory factor|regulation of adaxial/abaxial pattern formation EEF1A1 186968.087010312 195037.008903306 178899.165117318 0.917257530369588 -0.124601251333669 0.324172996702989 1 1950.44 2102.2 1771.59 1940.66 GeneID:1915,Genbank:NM_001402.5,HGNC:HGNC:3189,MIM:130590 eukaryotic translation elongation factor 1 alpha 1 hsa03013,hsa05134 RNA transport|Legionellosis EEF1A2 2327.90519848638 2321.98424902384 2333.82614794892 1.00509990493263 0.00733890955086547 0.974754621507452 1 46.4213 46.6236 45.3615 50.2202 GeneID:1917,Genbank:NM_001958.3,HGNC:HGNC:3192,MIM:602959 eukaryotic translation elongation factor 1 alpha 2 hsa03013,hsa05134 RNA transport|Legionellosis EEF1AKMT1 56.7105957211997 63.996422901712 49.4247685406875 0.77230517425319 -0.372757057777659 0.331442138593403 1 2.13077 2.15454 1.5624 2.17463 GeneID:221143,Genbank:NM_001318939.1,HGNC:HGNC:27351,MIM:617793 EEF1A lysine methyltransferase 1 GO:0003676,GO:0005829,GO:0006479,GO:0008168,GO:0016279,GO:0018022,GO:0070062 nucleic acid binding|cytosol|protein methylation|methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|extracellular exosome EEF1AKMT2 444.686761459504 460.955931135445 428.417591783564 0.929411171103208 -0.105611109390627 0.57616147008313 1 4.82707 4.55153 4.18589 3.99577 GeneID:399818,Genbank:NM_212554.3,HGNC:HGNC:33787,MIM:617794 EEF1A lysine methyltransferase 2 GO:0005634,GO:0005737,GO:0005829,GO:0006479,GO:0008168,GO:0016279,GO:0018022 nucleus|cytoplasm|cytosol|protein methylation|methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation EEF1AKMT3 128.03608517225 141.695227748014 114.376942596485 0.807203915151531 -0.308994922975303 0.255381536166989 1 2.20015 2.03352 1.90694 1.63724 GeneID:25895,Genbank:NM_206914.1,HGNC:HGNC:24936,MIM:615258 EEF1A lysine methyltransferase 3 GO:0005622,GO:0005737,GO:0005813,GO:0008168,GO:0016279,GO:0018022,GO:0031072,GO:0043234 intracellular|cytoplasm|centrosome|methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|heat shock protein binding|protein complex EEF1AKMT4 85.8335754621228 91.2188903472607 80.4482605769849 0.88192544626148 -0.181271392454845 0.576045131403351 1 15.2677 16.6112 15.0071 13.4763 GeneID:110599564,Genbank:NM_032331.3,HGNC:HGNC:53611 EEF1A lysine methyltransferase 4 EEF1B2 6144.75796138903 6698.4857248124 5591.03019796566 0.834670764058729 -0.260720856254898 0.170109655000123 1 227.748 252.273 182.351 220.476 GeneID:1933,Genbank:NM_001959.3,HGNC:HGNC:3208,MIM:600655 eukaryotic translation elongation factor 1 beta 2 GO:0003746,GO:0005737,GO:0005829,GO:0005853,GO:0006414 translation elongation factor activity|cytoplasm|cytosol|eukaryotic translation elongation factor 1 complex|translational elongation EEF1D 7219.27382453717 7202.63456590414 7235.91308317019 1.00462032565467 0.00665036927682051 0.981732282075187 1 47.0834 49.1413 45.7654 52.5775 GeneID:1936,Genbank:NM_001317743.2,HGNC:HGNC:3211,MIM:130592 eukaryotic translation elongation factor 1 delta GO:0001650,GO:0003677,GO:0003746,GO:0004871,GO:0005634,GO:0005737,GO:0005829,GO:0005853,GO:0006351,GO:0006355,GO:0006414,GO:0008135,GO:0009299,GO:0010941,GO:0031072,GO:0033613,GO:0043123,GO:0045296,GO:0071479 fibrillar center|DNA binding|translation elongation factor activity|signal transducer activity|nucleus|cytoplasm|cytosol|eukaryotic translation elongation factor 1 complex|transcription, DNA-templated|regulation of transcription, DNA-templated|translational elongation|translation factor activity, RNA binding|mRNA transcription|regulation of cell death|heat shock protein binding|activating transcription factor binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|cadherin binding|cellular response to ionizing radiation hsa05168 Herpes simplex infection EEF1E1 1055.86452631387 1182.73265831412 928.99639431362 0.785466088031949 -0.34837910540769 0.0204234444994321 0.586204098750725 37.9512 43.8504 31.3606 33.0121 GeneID:9521,Genbank:NM_001135650.1,HGNC:HGNC:3212,MIM:609206 eukaryotic translation elongation factor 1 epsilon 1 GO:0004364,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006418,GO:0006749,GO:0008285,GO:0017101,GO:0043065,GO:0043517,GO:0070062,GO:2000774 glutathione transferase activity|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|tRNA aminoacylation for protein translation|glutathione metabolic process|negative regulation of cell proliferation|aminoacyl-tRNA synthetase multienzyme complex|positive regulation of apoptotic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|extracellular exosome|positive regulation of cellular senescence EEF1G 23870.1208025514 24936.0585961751 22804.1830089277 0.914506313055648 -0.128934965610321 0.395561228869236 1 573.39 599.55 508.026 569.09 GeneID:1937,Genbank:NM_001404.4,HGNC:HGNC:3213,MIM:130593 eukaryotic translation elongation factor 1 gamma GO:0003746,GO:0004364,GO:0005634,GO:0005737,GO:0005829,GO:0006414,GO:0006749,GO:0009615,GO:0016020,GO:0045296,GO:0070062 translation elongation factor activity|glutathione transferase activity|nucleus|cytoplasm|cytosol|translational elongation|glutathione metabolic process|response to virus|membrane|cadherin binding|extracellular exosome hsa05134 Legionellosis EEF2 71479.0658469688 72024.1323824025 70933.9993115351 0.984864335955073 -0.0220030863837954 0.845538411674848 1 749.539 771.682 741.504 783.028 GeneID:1938,Genbank:NM_001961.3,HGNC:HGNC:3214,MIM:130610 eukaryotic translation elongation factor 2 GO:0002039,GO:0002244,GO:0002931,GO:0003009,GO:0003723,GO:0003746,GO:0003924,GO:0005525,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006414,GO:0006479,GO:0007568,GO:0008097,GO:0014009,GO:0016020,GO:0016235,GO:0017183,GO:0019901,GO:0030529,GO:0031012,GO:0032355,GO:0034774,GO:0034976,GO:0035914,GO:0042542,GO:0042788,GO:0043022,GO:0043312,GO:0045121,GO:0045296,GO:0045471,GO:0045727,GO:0051015,GO:0051593,GO:0070062,GO:1904813,GO:1990416,GO:2000767 p53 binding|hematopoietic progenitor cell differentiation|response to ischemia|skeletal muscle contraction|RNA binding|translation elongation factor activity|GTPase activity|GTP binding|extracellular region|nucleus|cytoplasm|cytosol|plasma membrane|translational elongation|protein methylation|aging|5S rRNA binding|glial cell proliferation|membrane|aggresome|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|protein kinase binding|intracellular ribonucleoprotein complex|extracellular matrix|response to estradiol|secretory granule lumen|response to endoplasmic reticulum stress|skeletal muscle cell differentiation|response to hydrogen peroxide|polysomal ribosome|ribosome binding|neutrophil degranulation|membrane raft|cadherin binding|response to ethanol|positive regulation of translation|actin filament binding|response to folic acid|extracellular exosome|ficolin-1-rich granule lumen|cellular response to brain-derived neurotrophic factor stimulus|positive regulation of cytoplasmic translation hsa04152,hsa04921 AMPK signaling pathway|Oxytocin signaling pathway EEF2K 859.137711965021 774.212333186404 944.063090743638 1.21938523874734 0.286153986686068 0.0690595034795503 0.918407228165493 3.92091 4.06818 5.05113 4.68247 GeneID:29904,Genbank:NM_013302.3,HGNC:HGNC:24615,MIM:606968 eukaryotic elongation factor 2 kinase GO:0002931,GO:0004672,GO:0004686,GO:0005509,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0006414,GO:0008135,GO:0014069,GO:0031952,GO:0032869,GO:0043066,GO:0043197,GO:0045807,GO:0046777,GO:0051965,GO:0061003,GO:0071277,GO:0071320,GO:0071454,GO:1990416,GO:1990637 response to ischemia|protein kinase activity|elongation factor-2 kinase activity|calcium ion binding|calmodulin binding|ATP binding|cytoplasm|cytosol|translational elongation|translation factor activity, RNA binding|postsynaptic density|regulation of protein autophosphorylation|cellular response to insulin stimulus|negative regulation of apoptotic process|dendritic spine|positive regulation of endocytosis|protein autophosphorylation|positive regulation of synapse assembly|positive regulation of dendritic spine morphogenesis|cellular response to calcium ion|cellular response to cAMP|cellular response to anoxia|cellular response to brain-derived neurotrophic factor stimulus|response to prolactin hsa04152,hsa04921 AMPK signaling pathway|Oxytocin signaling pathway EEF2KMT 308.1418175727 322.124696560021 294.158938585379 0.913183440222716 -0.131023397091264 0.513042674379167 1 4.35889 4.23279 3.6075 4.08131 GeneID:196483,Genbank:XM_005255157.4,HGNC:HGNC:32221,MIM:615263 eukaryotic elongation factor 2 lysine methyltransferase GO:0005737,GO:0005829,GO:0006479,GO:0016279,GO:0018023,GO:0043234 cytoplasm|cytosol|protein methylation|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|protein complex EEFSEC 454.525616672416 470.489835837553 438.561397507278 0.932137878656958 -0.101384725691968 0.637117667747887 1 3.37227 4.12569 3.29981 3.55617 GeneID:60678,Genbank:XM_024453695.1,HGNC:HGNC:24614,MIM:607695 eukaryotic elongation factor, selenocysteine-tRNA specific GO:0000049,GO:0001514,GO:0003746,GO:0003924,GO:0005525,GO:0005634,GO:0005739,GO:0030529,GO:0035368,GO:0043021 tRNA binding|selenocysteine incorporation|translation elongation factor activity|GTPase activity|GTP binding|nucleus|mitochondrion|intracellular ribonucleoprotein complex|selenocysteine insertion sequence binding|ribonucleoprotein complex binding EEPD1 186.57350929297 172.992153888385 200.154864697555 1.15701701030149 0.210410074901075 0.379507129654113 1 0.779736 0.826992 0.946278 0.916995 GeneID:80820,Genbank:NM_030636.2,HGNC:HGNC:22223,MIM:617192 endonuclease/exonuclease/phosphatase family domain containing 1 GO:0003677,GO:0006281 DNA binding|DNA repair EFCAB1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:79645,Genbank:XM_024447272.1,HGNC:HGNC:25678 EF-hand calcium binding domain 1 GO:0005509 calcium ion binding EFCAB10 10.8043312723069 13.856269423753 7.75239312086075 0.559486315095119 -0.837825251238618 0.355968975251953 1 0.134189 0.110748 0 0.0513397 GeneID:100130771,Genbank:XM_024446617.1,HGNC:HGNC:34531 EF-hand calcium binding domain 10 GO:0005509 calcium ion binding EFCAB11 131.313017503268 136.131954537959 126.494080468577 0.929201970969313 -0.105935880576374 0.676810231828982 1 0.909751 1.24968 0.976614 0.791102 GeneID:90141,Genbank:NM_001284267.1,HGNC:HGNC:20357 EF-hand calcium binding domain 11 GO:0005509 calcium ion binding EFCAB12 2.48206902828108 2.05633815719933 2.90779989936283 1.41406698561834 0.499850463520999 0.908170413273276 1 0.00596627 0.0110102 0.0169921 0.00528021 GeneID:90288,Genbank:NM_207307.2,HGNC:HGNC:28061 EF-hand calcium binding domain 12 GO:0005509 calcium ion binding EFCAB13 1.02273099320278 1.07619535328461 0.969266633120943 0.900641904987498 -0.150974490057726 1 1 0.00899451 0 0 0.0081359 GeneID:124989,Genbank:NM_152347.4,HGNC:HGNC:26864 EF-hand calcium binding domain 13 EFCAB14 2060.06332048945 2090.74901654083 2029.37762443807 0.970646217399975 -0.0429825391059902 0.815235377290367 1 13.7711 13.3221 15.3105 11.1435 GeneID:9813,Genbank:NM_014774.2,HGNC:HGNC:29051 EF-hand calcium binding domain 14 GO:0005509 calcium ion binding EFCAB2 195.39514246843 212.917243164393 177.873041772467 0.8354092845131 -0.259444917574622 0.275012097638093 1 0.321356 0.277367 0.242864 0.24005 GeneID:84288,Genbank:XM_011544301.1,HGNC:HGNC:28166 EF-hand calcium binding domain 2 GO:0005509 calcium ion binding EFCAB5 9.04486159853637 10.819788462639 7.26993473443377 0.671910986017616 -0.573657975777743 0.590559897642094 1 0.0090759 0.00872635 0.0131009 0.00407017 GeneID:374786,Genbank:NM_001145053.1,HGNC:HGNC:24801 EF-hand calcium binding domain 5 GO:0005509 calcium ion binding EFCAB6 2.02351541272148 2.59443583384164 1.45259499160132 0.559888578724427 -0.836788344351891 0.824528416670166 1 0.0107837 0 0 0 GeneID:64800,Genbank:NM_198856.2,HGNC:HGNC:24204 EF-hand calcium binding domain 6 GO:0005509,GO:0005654,GO:0006351,GO:0006355 calcium ion binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated EFCAB7 49.0379264671971 54.4449348910974 43.6309180432968 0.801376989991242 -0.319447008754921 0.512394236580363 1 0.323472 0.337757 0.343458 0.156055 GeneID:84455,Genbank:NM_032437.3,HGNC:HGNC:29379,MIM:617632 EF-hand calcium binding domain 7 GO:0005509,GO:0005929,GO:0019898,GO:0042307,GO:0045944,GO:0060170,GO:0098797,GO:1903569 calcium ion binding|cilium|extrinsic component of membrane|positive regulation of protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|ciliary membrane|plasma membrane protein complex|positive regulation of protein localization to ciliary membrane EFCAB8 39.713262652342 47.4398564396395 31.9866688650445 0.674257286291391 -0.568628888008005 0.217944384120345 1 0.224274 0.185479 0.154636 0.127052 GeneID:388795,Genbank:XM_024451883.1,HGNC:HGNC:34532 EF-hand calcium binding domain 8 GO:0005509 calcium ion binding EFEMP1 1559.32631879909 1521.62360974346 1597.02902785471 1.04955589386784 0.0697789990824175 0.680958668828693 1 16.1952 15.9279 19.321 14.2252 GeneID:2202,Genbank:NM_001039349.2,HGNC:HGNC:3218,MIM:601548 EGF containing fibulin extracellular matrix protein 1 EFEMP2 115.61037022626 121.717970127348 109.502770325171 0.899643415106278 -0.152574810331009 0.672225720861572 1 2.71113 2.26845 1.79129 2.58714 GeneID:30008,Genbank:NM_016938.4,HGNC:HGNC:3219,MIM:604633 EGF containing fibulin extracellular matrix protein 2 GO:0005201,GO:0005509,GO:0005576,GO:0005604,GO:0048251,GO:0070062,GO:1903561 extracellular matrix structural constituent|calcium ion binding|extracellular region|basement membrane|elastic fiber assembly|extracellular exosome|extracellular vesicle EFHB 31.7660950885528 33.4875344665166 30.044655710589 0.897189243377413 -0.156515771185302 0.793343520078688 1 0.193404 0.209315 0.194275 0.188765 GeneID:151651,Genbank:XM_011533383.3,HGNC:HGNC:26330 EF-hand domain family member B GO:0005509 calcium ion binding EFHC1 378.417891133966 354.084181890873 402.75160037706 1.13744589839143 0.185797926429055 0.315851304900977 1 2.15169 2.19544 2.75647 2.3487 GeneID:114327,Genbank:NM_018100.3,HGNC:HGNC:16406,MIM:608815 EF-hand domain containing 1 GO:0000281,GO:0000922,GO:0005509,GO:0005813,GO:0005930,GO:0007052,GO:0008022,GO:0021795,GO:0043014,GO:0043025,GO:0051302,GO:0072686 mitotic cytokinesis|spindle pole|calcium ion binding|centrosome|axoneme|mitotic spindle organization|protein C-terminus binding|cerebral cortex cell migration|alpha-tubulin binding|neuronal cell body|regulation of cell division|mitotic spindle EFHC2 1.51280239516014 2.05633815719933 0.969266633120943 0.471355661872779 -1.08511203720016 0.811646606184739 1 0.0159666 0.00772528 0.00772558 0 GeneID:80258,Genbank:XM_024452453.1,HGNC:HGNC:26233,MIM:300817 EF-hand domain containing 2 GO:0005509,GO:1990830 calcium ion binding|cellular response to leukemia inhibitory factor EFHD1 38.678420178156 29.3846668072258 47.9721735490862 1.6325580229921 0.707134267725995 0.134168086048686 1 0.478028 0.776495 0.820341 0.985691 GeneID:80303,Genbank:NM_001243252.1,HGNC:HGNC:29556,MIM:611617 EF-hand domain family member D1 GO:0005509,GO:0005743,GO:0031175,GO:0070062 calcium ion binding|mitochondrial inner membrane|neuron projection development|extracellular exosome EFHD2 2498.1604238202 2438.38009431541 2557.940753325 1.04903282276964 0.0690598185311703 0.641151135101741 1 44.5848 47.5233 52.647 47.0215 GeneID:79180,Genbank:NM_024329.5,HGNC:HGNC:28670,MIM:616450 EF-hand domain family member D2 GO:0005509,GO:0045121,GO:0045296 calcium ion binding|membrane raft|cadherin binding EFL1 775.902308555876 834.527299245027 717.277317866726 0.859501323103063 -0.218428234319851 0.177401228761212 1 5.56826 5.01457 4.75779 4.30932 GeneID:79631,Genbank:NM_001040610.2,HGNC:HGNC:25789,MIM:617538 elongation factor like GTPase 1 GO:0003746,GO:0003924,GO:0005525,GO:0042256,GO:0043022,GO:0046039 translation elongation factor activity|GTPase activity|GTP binding|mature ribosome assembly|ribosome binding|GTP metabolic process hsa03008 Ribosome biogenesis in eukaryotes EFNA1 178.204769797805 171.762071055937 184.647468539673 1.07501887584681 0.104361991769621 0.671534004966672 1 3.90015 3.91677 4.32101 3.93389 GeneID:1942,Genbank:NM_004428.2,HGNC:HGNC:3221,MIM:191164 ephrin A1 GO:0000122,GO:0001525,GO:0001934,GO:0003180,GO:0003183,GO:0003199,GO:0005102,GO:0005886,GO:0005887,GO:0007267,GO:0007411,GO:0010719,GO:0014028,GO:0016477,GO:0033628,GO:0034446,GO:0043409,GO:0043410,GO:0043535,GO:0045765,GO:0046658,GO:0046875,GO:0048013,GO:0050730,GO:0050731,GO:0050770,GO:0050821,GO:0061002,GO:0061098,GO:0070062,GO:0070244,GO:1902004,GO:1902961,GO:1903051 negative regulation of transcription from RNA polymerase II promoter|angiogenesis|positive regulation of protein phosphorylation|aortic valve morphogenesis|mitral valve morphogenesis|endocardial cushion to mesenchymal transition involved in heart valve formation|receptor binding|plasma membrane|integral component of plasma membrane|cell-cell signaling|axon guidance|negative regulation of epithelial to mesenchymal transition|notochord formation|cell migration|regulation of cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading|negative regulation of MAPK cascade|positive regulation of MAPK cascade|regulation of blood vessel endothelial cell migration|regulation of angiogenesis|anchored component of plasma membrane|ephrin receptor binding|ephrin receptor signaling pathway|regulation of peptidyl-tyrosine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of axonogenesis|protein stabilization|negative regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|extracellular exosome|negative regulation of thymocyte apoptotic process|positive regulation of amyloid-beta formation|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of proteolysis involved in cellular protein catabolic process hsa04010,hsa04014,hsa04015,hsa04151,hsa04360 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance EFNA2 15.2422036606953 14.9804910517226 15.5039162696681 1.03494045796886 0.0495477692086285 0.985491070026401 1 0.172739 0.111928 0.10964 0.186951 GeneID:1943,Genbank:XM_017026449.1,HGNC:HGNC:3222,MIM:602756 ephrin A2 GO:0005886,GO:0007267,GO:0007411,GO:0021772,GO:0030316,GO:0031225,GO:0031594,GO:0043204,GO:0046849,GO:0046875,GO:0048013 plasma membrane|cell-cell signaling|axon guidance|olfactory bulb development|osteoclast differentiation|anchored component of membrane|neuromuscular junction|perikaryon|bone remodeling|ephrin receptor binding|ephrin receptor signaling pathway hsa04010,hsa04014,hsa04015,hsa04151,hsa04360 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance EFNA3 68.5281228062475 58.0675398035387 78.9887058089564 1.36029020819895 0.443914472993904 0.205673954491691 1 1.33044 1.15018 1.66717 1.87024 GeneID:1944,Genbank:NM_004952.4,HGNC:HGNC:3223,MIM:601381 ephrin A3 GO:0005005,GO:0005886,GO:0005887,GO:0007267,GO:0007411,GO:0016525,GO:0031225,GO:0045664,GO:0046875,GO:0048013,GO:1902961 transmembrane-ephrin receptor activity|plasma membrane|integral component of plasma membrane|cell-cell signaling|axon guidance|negative regulation of angiogenesis|anchored component of membrane|regulation of neuron differentiation|ephrin receptor binding|ephrin receptor signaling pathway|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process hsa04010,hsa04014,hsa04015,hsa04151,hsa04360,hsa05206 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance|MicroRNAs in cancer EFNA4 197.404393699605 199.532444833236 195.276342565974 0.97866962302387 -0.0311061744520522 0.906091536049806 1 6.36954 7.19156 5.65608 7.34537 GeneID:1945,Genbank:NM_005227.2,HGNC:HGNC:3224,MIM:601380 ephrin A4 GO:0005005,GO:0005576,GO:0005886,GO:0005887,GO:0007267,GO:0007411,GO:0030316,GO:0031225,GO:0046849,GO:0046875,GO:0048013 transmembrane-ephrin receptor activity|extracellular region|plasma membrane|integral component of plasma membrane|cell-cell signaling|axon guidance|osteoclast differentiation|anchored component of membrane|bone remodeling|ephrin receptor binding|ephrin receptor signaling pathway hsa04010,hsa04014,hsa04015,hsa04151,hsa04360 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance EFNA5 154.870815115348 157.559809054282 152.181821176415 0.96586700688363 -0.050103541145494 0.856089880635972 1 0.805653 0.764303 0.790419 0.627134 GeneID:1946,Genbank:NM_001962.2,HGNC:HGNC:3225,MIM:601535 ephrin A5 GO:0001934,GO:0005168,GO:0005169,GO:0005170,GO:0005604,GO:0005886,GO:0005901,GO:0005912,GO:0007399,GO:0007411,GO:0022407,GO:0022604,GO:0030297,GO:0031290,GO:0031362,GO:0032956,GO:0043087,GO:0045499,GO:0046875,GO:0048013,GO:0048668,GO:0048672,GO:0050731,GO:0051893,GO:0051965,GO:0061178,GO:0070507,GO:0071372,GO:1900025,GO:1904322 positive regulation of protein phosphorylation|neurotrophin TRKA receptor binding|neurotrophin TRKB receptor binding|neurotrophin TRKC receptor binding|basement membrane|plasma membrane|caveola|adherens junction|nervous system development|axon guidance|regulation of cell-cell adhesion|regulation of cell morphogenesis|transmembrane receptor protein tyrosine kinase activator activity|retinal ganglion cell axon guidance|anchored component of external side of plasma membrane|regulation of actin cytoskeleton organization|regulation of GTPase activity|chemorepellent activity|ephrin receptor binding|ephrin receptor signaling pathway|collateral sprouting|positive regulation of collateral sprouting|positive regulation of peptidyl-tyrosine phosphorylation|regulation of focal adhesion assembly|positive regulation of synapse assembly|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of microtubule cytoskeleton organization|cellular response to follicle-stimulating hormone stimulus|negative regulation of substrate adhesion-dependent cell spreading|cellular response to forskolin hsa04010,hsa04014,hsa04015,hsa04151,hsa04360 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance EFNB1 349.428817673751 349.914687647536 348.942947699967 0.997222923238512 -0.00401204833711644 0.965706116524219 1 4.36357 4.91595 4.96691 4.50104 GeneID:1947,Genbank:NM_004429.4,HGNC:HGNC:3226,MIM:300035 ephrin B1 GO:0001755,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0007155,GO:0007267,GO:0007411,GO:0009880,GO:0031295,GO:0042102,GO:0045121,GO:0045202,GO:0046875,GO:0048013,GO:0070062 neural crest cell migration|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|cell adhesion|cell-cell signaling|axon guidance|embryonic pattern specification|T cell costimulation|positive regulation of T cell proliferation|membrane raft|synapse|ephrin receptor binding|ephrin receptor signaling pathway|extracellular exosome hsa04360 Axon guidance EFNB2 3005.82701138498 2699.06829283796 3312.585729932 1.22730711880171 0.29549631120946 0.0281893395331311 0.668561867500627 8.93679 8.31443 11.4201 9.86037 GeneID:1948,Genbank:NM_004093.3,HGNC:HGNC:3227,MIM:600527 ephrin B2 GO:0001618,GO:0001945,GO:0002042,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0007267,GO:0007411,GO:0008284,GO:0009653,GO:0009887,GO:0010839,GO:0010977,GO:0031295,GO:0046875,GO:0048013,GO:0048845,GO:0050920,GO:0072178,GO:1901216,GO:1903849,GO:2000727 virus receptor activity|lymph vessel development|cell migration involved in sprouting angiogenesis|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|cell-cell signaling|axon guidance|positive regulation of cell proliferation|anatomical structure morphogenesis|animal organ morphogenesis|negative regulation of keratinocyte proliferation|negative regulation of neuron projection development|T cell costimulation|ephrin receptor binding|ephrin receptor signaling pathway|venous blood vessel morphogenesis|regulation of chemotaxis|nephric duct morphogenesis|positive regulation of neuron death|positive regulation of aorta morphogenesis|positive regulation of cardiac muscle cell differentiation hsa04360 Axon guidance EFNB3 458.43458738039 452.606116992809 464.263057767971 1.02575515517248 0.0366864048500696 0.840103990490011 1 6.97795 6.45774 6.93038 7.06991 GeneID:1949,Genbank:NM_001406.3,HGNC:HGNC:3228,MIM:602297 ephrin B3 GO:0001618,GO:0005005,GO:0005886,GO:0005887,GO:0007267,GO:0007399,GO:0007411,GO:0007628,GO:0016198,GO:0031295,GO:0046875,GO:0048013,GO:0050771 virus receptor activity|transmembrane-ephrin receptor activity|plasma membrane|integral component of plasma membrane|cell-cell signaling|nervous system development|axon guidance|adult walking behavior|axon choice point recognition|T cell costimulation|ephrin receptor binding|ephrin receptor signaling pathway|negative regulation of axonogenesis hsa04360 Axon guidance EFR3A 1323.13881716686 1420.43857822193 1225.83905611179 0.863000396431271 -0.212566872760887 0.461903662797229 1 9.85226 8.60624 9.77365 6.33192 GeneID:23167,Genbank:NM_001323555.1,HGNC:HGNC:28970,MIM:611798 EFR3 homolog A GO:0005829,GO:0005886,GO:0046854,GO:0070062,GO:0072659 cytosol|plasma membrane|phosphatidylinositol phosphorylation|extracellular exosome|protein localization to plasma membrane EFR3B 162.246178484846 134.988115599774 189.504241369919 1.40385870658258 0.489397740791811 0.0464707692922725 0.79332376136203 0.700236 0.706134 1.0995 0.930717 GeneID:22979,Genbank:NM_014971.1,HGNC:HGNC:29155,MIM:616797 EFR3 homolog B GO:0005829,GO:0005886,GO:0046854,GO:0072659 cytosol|plasma membrane|phosphatidylinositol phosphorylation|protein localization to plasma membrane EFTUD2 6976.86513456129 7107.47243602844 6846.25783309414 0.963247890824004 -0.0540209729966514 0.673964933181528 1 47.5171 48.9724 48.0245 46.5372 GeneID:9343,Genbank:NM_001142605.1,HGNC:HGNC:30858,MIM:603892 elongation factor Tu GTP binding domain containing 2 GO:0000398,GO:0003723,GO:0003924,GO:0005525,GO:0005654,GO:0005681,GO:0005829,GO:0006397,GO:0008380,GO:0015030,GO:0016020,GO:0016607,GO:0031012,GO:0035690,GO:0042220,GO:0046540,GO:0071013 mRNA splicing, via spliceosome|RNA binding|GTPase activity|GTP binding|nucleoplasm|spliceosomal complex|cytosol|mRNA processing|RNA splicing|Cajal body|membrane|nuclear speck|extracellular matrix|cellular response to drug|response to cocaine|U4/U6 x U5 tri-snRNP complex|catalytic step 2 spliceosome hsa03040 Spliceosome EGF 423.551605643403 410.39334984043 436.709861446375 1.06412509270966 0.0896677561247177 0.676600331716991 1 2.21292 2.16845 2.80014 1.9067 GeneID:1950,Genbank:XM_017007845.1,HGNC:HGNC:3229,MIM:131530 epidermal growth factor hsa01521,hsa04010,hsa04012,hsa04014,hsa04015,hsa04066,hsa04068,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05160,hsa05165,hsa05200,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05223,hsa05224,hsa05226,hsa05231 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Jak-STAT signaling pathway|Regulation of actin cytoskeleton|Hepatitis C|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Non-small cell lung cancer|Breast cancer|Gastric cancer|Choline metabolism in cancer EGFL7 118.745618707843 121.189681105814 116.301556309872 0.95966550327273 -0.059396460785089 0.832172933719086 1 1.93317 2.28204 1.8116 2.31689 GeneID:51162,Genbank:XM_011518766.1,HGNC:HGNC:20594,MIM:608582 EGF like domain multiple 7 GO:0001525,GO:0001568,GO:0001570,GO:0001938,GO:0005509,GO:0005576,GO:0005615,GO:0007155,GO:0031012,GO:0045746 angiogenesis|blood vessel development|vasculogenesis|positive regulation of endothelial cell proliferation|calcium ion binding|extracellular region|extracellular space|cell adhesion|extracellular matrix|negative regulation of Notch signaling pathway EGFL8 84.4351341019583 74.3741662370785 94.4961019668381 1.27055006795798 0.345453228103933 0.284355383421378 1 1.65889 1.7378 2.22054 2.3552 GeneID:80864,Genbank:NM_030652.3,HGNC:HGNC:13944,MIM:609897 EGF like domain multiple 8 GO:0005509,GO:0005576 calcium ion binding|extracellular region EGFLAM 3.6984379260391 3.03648096111406 4.36039489096415 1.43600271063921 0.522058472435378 0.832263033314671 1 0.0143398 0.0263727 0.00681364 0.0316909 GeneID:133584,Genbank:NM_001205301.1,HGNC:HGNC:26810,MIM:617683 EGF like, fibronectin type III and laminin G domains GO:0005509,GO:0005539,GO:0005604,GO:0005614,GO:0010811,GO:0019800,GO:0030054,GO:0030198,GO:0045202 calcium ion binding|glycosaminoglycan binding|basement membrane|interstitial matrix|positive regulation of cell-substrate adhesion|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|cell junction|extracellular matrix organization|synapse EGFR 1608.00625604408 1638.24876075249 1577.76375133566 0.963079471893481 -0.054273242845671 0.855059942988442 1 7.07083 6.57624 8.23804 5.1352 GeneID:1956,Genbank:NM_005228.4,HGNC:HGNC:3236,MIM:131550 epidermal growth factor receptor hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04066,hsa04068,hsa04072,hsa04144,hsa04151,hsa04510,hsa04520,hsa04540,hsa04630,hsa04810,hsa04912,hsa04915,hsa04921,hsa04926,hsa04928,hsa04934,hsa05120,hsa05160,hsa05163,hsa05165,hsa05200,hsa05205,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Focal adhesion|Adherens junction|Gap junction|Jak-STAT signaling pathway|Regulation of actin cytoskeleton|GnRH signaling pathway|Estrogen signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Epithelial cell signaling in Helicobacter pylori infection|Hepatitis C|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer EGLN1 1153.67007681005 1146.58202742801 1160.75812619209 1.01236378944112 0.0177278106963567 0.901312418417581 1 8.10724 7.85377 8.75879 7.21746 GeneID:54583,Genbank:NM_022051.2,HGNC:HGNC:1232,MIM:606425 egl-9 family hypoxia inducible factor 1 hsa04066,hsa05200,hsa05211 HIF-1 signaling pathway|Pathways in cancer|Renal cell carcinoma EGLN2 2019.70901891064 1912.93665187544 2126.48138594585 1.11163189008954 0.152679127753036 0.292187904213118 1 35.3543 38.1803 40.9767 42.4692 GeneID:112398,Genbank:NM_080732.3,HGNC:HGNC:14660,MIM:606424 egl-9 family hypoxia inducible factor 2 GO:0001558,GO:0001666,GO:0005634,GO:0005654,GO:0008198,GO:0016706,GO:0018401,GO:0019826,GO:0030520,GO:0031418,GO:0031545,GO:0043523,GO:0045454,GO:0045732,GO:0061418 regulation of cell growth|response to hypoxia|nucleus|nucleoplasm|ferrous iron binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|oxygen sensor activity|intracellular estrogen receptor signaling pathway|L-ascorbic acid binding|peptidyl-proline 4-dioxygenase activity|regulation of neuron apoptotic process|cell redox homeostasis|positive regulation of protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia hsa04066,hsa05200,hsa05211 HIF-1 signaling pathway|Pathways in cancer|Renal cell carcinoma EGLN3 330.524750742894 328.601485989945 332.448015495843 1.01170575809878 0.0167897613205969 0.952802251064987 1 5.49257 6.08248 6.12226 5.82812 GeneID:112399,Genbank:NM_022073.3,HGNC:HGNC:14661,MIM:606426 egl-9 family hypoxia inducible factor 3 GO:0001666,GO:0005506,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0006919,GO:0006974,GO:0016706,GO:0018126,GO:0018401,GO:0031418,GO:0031545,GO:0042127,GO:0043523,GO:0061418 response to hypoxia|iron ion binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein hydroxylation|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|L-ascorbic acid binding|peptidyl-proline 4-dioxygenase activity|regulation of cell proliferation|regulation of neuron apoptotic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia hsa04066,hsa05200,hsa05211 HIF-1 signaling pathway|Pathways in cancer|Renal cell carcinoma EGR1 368.402994673659 330.167752745187 406.638236602131 1.23161100144133 0.300546659515468 0.11504687930822 1 4.84112 5.09453 6.93091 5.52246 GeneID:1958,Genbank:NM_001964.2,HGNC:HGNC:3238,MIM:128990 early growth response 1 hsa04371,hsa04912,hsa04928,hsa04933,hsa05020,hsa05166 Apelin signaling pathway|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action|AGE-RAGE signaling pathway in diabetic complications|Prion diseases|Human T-cell leukemia virus 1 infection EGR2 19.9844587762268 17.1907166880847 22.7782008643689 1.32502915833387 0.406024107691548 0.566608673882516 1 0.155828 0.292574 0.292798 0.26126 GeneID:1959,Genbank:NM_001136178.1,HGNC:HGNC:3239,MIM:129010 early growth response 2 hsa04625,hsa05161,hsa05166,hsa05203 C-type lectin receptor signaling pathway|Hepatitis B|Human T-cell leukemia virus 1 infection|Viral carcinogenesis EGR3 8.12828481372415 6.56303332418548 9.69353630326283 1.47699026112531 0.562660313392791 0.638084116719983 1 0.0436068 0.0872995 0.11177 0.0855297 GeneID:1960,Genbank:NM_004430.2,HGNC:HGNC:3240,MIM:602419 early growth response 3 GO:0001938,GO:0002042,GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0007517,GO:0007623,GO:0035767,GO:0035924,GO:0043066,GO:0044344,GO:0046872 positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|muscle organ development|circadian rhythm|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|negative regulation of apoptotic process|cellular response to fibroblast growth factor stimulus|metal ion binding hsa04625,hsa05161,hsa05203 C-type lectin receptor signaling pathway|Hepatitis B|Viral carcinogenesis EHBP1 483.124893501881 509.174016625152 457.075770378609 0.897680862444919 -0.155725456157899 0.555711860851087 1 2.04581 1.81554 2.03199 1.48951 GeneID:23301,Genbank:NM_001142615.2,HGNC:HGNC:29144,MIM:609922 EH domain binding protein 1 GO:0005768,GO:0005829,GO:0005886,GO:0006897,GO:0015031 endosome|cytosol|plasma membrane|endocytosis|protein transport EHBP1L1 16.7833561472701 12.2419763938261 21.3247359007141 1.74193571484655 0.800691383073754 0.263645087572446 1 0.0682382 0.0875947 0.13506 0.106302 GeneID:254102,Genbank:XM_005273869.3,HGNC:HGNC:30682 EH domain binding protein 1 like 1 GO:0005768,GO:0016020 endosome|membrane EHD1 1495.15177103764 1518.00405583358 1472.2994862417 0.969891668328391 -0.0441044798488629 0.731954840280057 1 16.6976 18.7892 17.96 17.2817 GeneID:10938,Genbank:NM_001282445.1,HGNC:HGNC:3242,MIM:605888 EH domain containing 1 GO:0005509,GO:0005524,GO:0005525,GO:0005811,GO:0005886,GO:0006886,GO:0006897,GO:0007596,GO:0010008,GO:0010886,GO:0016020,GO:0017137,GO:0020018,GO:0031095,GO:0031175,GO:0031901,GO:0032456,GO:0034383,GO:0042632,GO:0042802,GO:0045296,GO:0051260,GO:0055038,GO:0060271,GO:0061512,GO:0070062,GO:1901741,GO:1990090,GO:2001137 calcium ion binding|ATP binding|GTP binding|lipid droplet|plasma membrane|intracellular protein transport|endocytosis|blood coagulation|endosome membrane|positive regulation of cholesterol storage|membrane|Rab GTPase binding|ciliary pocket membrane|platelet dense tubular network membrane|neuron projection development|early endosome membrane|endocytic recycling|low-density lipoprotein particle clearance|cholesterol homeostasis|identical protein binding|cadherin binding|protein homooligomerization|recycling endosome membrane|cilium assembly|protein localization to cilium|extracellular exosome|positive regulation of myoblast fusion|cellular response to nerve growth factor stimulus|positive regulation of endocytic recycling hsa04144 Endocytosis EHD2 2495.46298887249 2302.37260129129 2688.55337645369 1.16773165861417 0.223708785121672 0.116221454176013 1 30.7134 32.1156 35.7831 39.2099 GeneID:30846,Genbank:NM_014601.3,HGNC:HGNC:3243,MIM:605890 EH domain containing 2 GO:0003676,GO:0005509,GO:0005524,GO:0005525,GO:0005634,GO:0005829,GO:0005886,GO:0005901,GO:0006897,GO:0007596,GO:0010008,GO:0015630,GO:0016787,GO:0019898,GO:0019904,GO:0030866,GO:0032456,GO:0042802,GO:0045171,GO:0048471,GO:0055038,GO:0070062,GO:0072659,GO:0097320,GO:1901741,GO:2001137 nucleic acid binding|calcium ion binding|ATP binding|GTP binding|nucleus|cytosol|plasma membrane|caveola|endocytosis|blood coagulation|endosome membrane|microtubule cytoskeleton|hydrolase activity|extrinsic component of membrane|protein domain specific binding|cortical actin cytoskeleton organization|endocytic recycling|identical protein binding|intercellular bridge|perinuclear region of cytoplasm|recycling endosome membrane|extracellular exosome|protein localization to plasma membrane|plasma membrane tubulation|positive regulation of myoblast fusion|positive regulation of endocytic recycling hsa04144 Endocytosis EHD3 26.9962112484743 20.073310170036 33.9191123269126 1.68976178017439 0.756819872078151 0.166891263191837 1 0.162159 0.137444 0.213374 0.283831 GeneID:30845,Genbank:NM_014600.2,HGNC:HGNC:3244,MIM:605891 EH domain containing 3 GO:0001881,GO:0003676,GO:0005509,GO:0005524,GO:0005525,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0007596,GO:0010008,GO:0015031,GO:0020018,GO:0030139,GO:0032456,GO:0034498,GO:0043209,GO:0048471,GO:0051260,GO:0055038,GO:0055117,GO:0060271,GO:0072659,GO:0086036,GO:0090160,GO:1901387,GO:1903358,GO:1903779 receptor recycling|nucleic acid binding|calcium ion binding|ATP binding|GTP binding|nucleus|cytoplasm|cytosol|focal adhesion|blood coagulation|endosome membrane|protein transport|ciliary pocket membrane|endocytic vesicle|endocytic recycling|early endosome to Golgi transport|myelin sheath|perinuclear region of cytoplasm|protein homooligomerization|recycling endosome membrane|regulation of cardiac muscle contraction|cilium assembly|protein localization to plasma membrane|regulation of cardiac muscle cell membrane potential|Golgi to lysosome transport|positive regulation of voltage-gated calcium channel activity|regulation of Golgi organization|regulation of cardiac conduction hsa04144 Endocytosis EHD4 3580.54663682355 3583.36744602371 3577.72582762339 0.998425609852939 -0.00227315474371542 0.969301351824582 1 45.4002 48.0514 51.5365 43.3479 GeneID:30844,Genbank:NM_139265.3,HGNC:HGNC:3245,MIM:605892 EH domain containing 4 GO:0003676,GO:0005509,GO:0005524,GO:0005525,GO:0005634,GO:0005783,GO:0005886,GO:0006907,GO:0016020,GO:0030100,GO:0031901,GO:0032456,GO:0045296,GO:0048471,GO:0050731,GO:0051260,GO:0055038,GO:0070062,GO:0071363 nucleic acid binding|calcium ion binding|ATP binding|GTP binding|nucleus|endoplasmic reticulum|plasma membrane|pinocytosis|membrane|regulation of endocytosis|early endosome membrane|endocytic recycling|cadherin binding|perinuclear region of cytoplasm|positive regulation of peptidyl-tyrosine phosphorylation|protein homooligomerization|recycling endosome membrane|extracellular exosome|cellular response to growth factor stimulus hsa04144 Endocytosis EHF 27.9604147289932 32.6514704866567 23.2693589713298 0.71265883663154 -0.488716498572347 0.417294839407153 1 0.165042 0.091315 0.149641 0.0674222 GeneID:26298,Genbank:NM_012153.5,HGNC:HGNC:3246,MIM:605439 ETS homologous factor EHHADH 111.083358543095 111.676410714776 110.490306371414 0.989379096840856 -0.0154046756845441 0.98843670838878 1 1.08618 1.00478 1.02572 1.02078 GeneID:1962,Genbank:NM_001966.3,HGNC:HGNC:3247,MIM:607037 enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase GO:0003857,GO:0004165,GO:0004300,GO:0005102,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0006475,GO:0006635,GO:0016508,GO:0019899,GO:0033540 3-hydroxyacyl-CoA dehydrogenase activity|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity|receptor binding|mitochondrion|peroxisome|peroxisomal matrix|cytosol|internal protein amino acid acetylation|fatty acid beta-oxidation|long-chain-enoyl-CoA hydratase activity|enzyme binding|fatty acid beta-oxidation using acyl-CoA oxidase hsa00071,hsa00280,hsa00310,hsa00380,hsa00410,hsa00640,hsa00650,hsa03320,hsa04146 Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism|PPAR signaling pathway|Peroxisome EHMT1 1720.36928443603 1584.63211518786 1856.1064536842 1.1713169485172 0.22813150981269 0.114148484013776 1 3.80066 3.85848 4.38798 4.31493 GeneID:79813,Genbank:NM_024757.4,HGNC:HGNC:24650,MIM:607001 euchromatic histone lysine methyltransferase 1 GO:0000122,GO:0002039,GO:0005634,GO:0005654,GO:0005694,GO:0006306,GO:0006325,GO:0008168,GO:0008270,GO:0009790,GO:0016279,GO:0016571,GO:0016604,GO:0018024,GO:0018026,GO:0018027,GO:0045892,GO:0046974,GO:0046976,GO:0060992,GO:0070317,GO:0070742,GO:1901796 negative regulation of transcription from RNA polymerase II promoter|p53 binding|nucleus|nucleoplasm|chromosome|DNA methylation|chromatin organization|methyltransferase activity|zinc ion binding|embryo development|protein-lysine N-methyltransferase activity|histone methylation|nuclear body|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K27 specific)|response to fungicide|negative regulation of G0 to G1 transition|C2H2 zinc finger domain binding|regulation of signal transduction by p53 class mediator hsa00310,hsa04211 Lysine degradation|Longevity regulating pathway EHMT2 1911.2017471918 1852.43735537148 1969.96613901212 1.06344548348685 0.0887460768161144 0.547092988153949 1 10.7161 11.6725 11.9693 12.2008 GeneID:10919,Genbank:NM_025256.6,HGNC:HGNC:14129,MIM:604599 euchromatic histone lysine methyltransferase 2 GO:0000122,GO:0000790,GO:0002039,GO:0005634,GO:0005654,GO:0006275,GO:0006306,GO:0008270,GO:0009267,GO:0016279,GO:0016571,GO:0016607,GO:0018024,GO:0018027,GO:0034968,GO:0046974,GO:0046976,GO:0070317,GO:0070742,GO:1901796,GO:1990841 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|p53 binding|nucleus|nucleoplasm|regulation of DNA replication|DNA methylation|zinc ion binding|cellular response to starvation|protein-lysine N-methyltransferase activity|histone methylation|nuclear speck|histone-lysine N-methyltransferase activity|peptidyl-lysine dimethylation|histone lysine methylation|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K27 specific)|negative regulation of G0 to G1 transition|C2H2 zinc finger domain binding|regulation of signal transduction by p53 class mediator|promoter-specific chromatin binding hsa00310,hsa04211 Lysine degradation|Longevity regulating pathway EI24 3158.07313628992 3158.53744345988 3157.60882911996 0.999705998628622 -0.00042421668370081 0.998322052758453 1 61.3114 60.1709 56.895 64.5599 GeneID:9538,Genbank:XM_011543070.1,HGNC:HGNC:13276,MIM:605170 EI24, autophagy associated transmembrane protein GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006915,GO:0016020,GO:0016021,GO:0016236,GO:0030308,GO:0031965 endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|apoptotic process|membrane|integral component of membrane|macroautophagy|negative regulation of cell growth|nuclear membrane hsa04115 p53 signaling pathway EID1 5901.88969717365 5785.46715365904 6018.31224068826 1.04024654895534 0.0569255022127311 0.642819803938805 1 127.188 118.214 136.691 120.747 GeneID:23741,Genbank:NM_014335.2,HGNC:HGNC:1191,MIM:605894 EP300 interacting inhibitor of differentiation 1 GO:0000122,GO:0003714,GO:0005634,GO:0005654,GO:0006351,GO:0007049,GO:0030154,GO:0035034,GO:0035035,GO:0036464,GO:0045595,GO:0045892 negative regulation of transcription from RNA polymerase II promoter|transcription corepressor activity|nucleus|nucleoplasm|transcription, DNA-templated|cell cycle|cell differentiation|histone acetyltransferase regulator activity|histone acetyltransferase binding|cytoplasmic ribonucleoprotein granule|regulation of cell differentiation|negative regulation of transcription, DNA-templated EID2 464.560820596809 501.660266462375 427.461374731244 0.852093345453947 -0.230916610860144 0.196644422520686 1 19.4944 18.7232 17.8384 15.3775 GeneID:163126,Genbank:NM_153232.3,HGNC:HGNC:28292,MIM:609773 EP300 interacting inhibitor of differentiation 2 GO:0000122,GO:0005622,GO:0005654,GO:0006351,GO:0007181,GO:0007183,GO:0007517,GO:0017015,GO:0030154,GO:0030512,GO:0042127,GO:0045892,GO:0046332 negative regulation of transcription from RNA polymerase II promoter|intracellular|nucleoplasm|transcription, DNA-templated|transforming growth factor beta receptor complex assembly|SMAD protein complex assembly|muscle organ development|regulation of transforming growth factor beta receptor signaling pathway|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of cell proliferation|negative regulation of transcription, DNA-templated|SMAD binding EID2B 81.1399106832221 87.6541203646122 74.625701001832 0.85136557975157 -0.232149330966384 0.465766387580522 1 3.00882 3.72982 2.6797 3.21708 GeneID:126272,Genbank:NM_152361.2,HGNC:HGNC:26796 EP300 interacting inhibitor of differentiation 2B GO:0005634,GO:0006351,GO:0007517,GO:0030154,GO:0042802,GO:0045662,GO:0045892 nucleus|transcription, DNA-templated|muscle organ development|cell differentiation|identical protein binding|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-templated EID3 31.4093443009905 28.8847867501605 33.9339018518204 1.17480188257342 0.232417482638834 0.676450115993186 1 0.975337 0.792094 1.42947 0.693114 GeneID:493861,Genbank:NM_001008394.2,HGNC:HGNC:32961,MIM:612986 EP300 interacting inhibitor of differentiation 3 GO:0000781,GO:0005634,GO:0005737,GO:0006281,GO:0006310,GO:0006351,GO:0006355,GO:0030915 chromosome, telomeric region|nucleus|cytoplasm|DNA repair|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|Smc5-Smc6 complex EIF1 11869.1720120987 11982.8476373468 11755.4963868506 0.981026943062546 -0.0276353355183395 0.81876139285119 1 360.341 389.288 354.288 379.255 GeneID:10209,Genbank:NM_005801.3,HGNC:HGNC:3249 eukaryotic translation initiation factor 1 GO:0003723,GO:0003743,GO:0005634,GO:0005737,GO:0006446,GO:0006950,GO:0008135,GO:0009048 RNA binding|translation initiation factor activity|nucleus|cytoplasm|regulation of translational initiation|response to stress|translation factor activity, RNA binding|dosage compensation by inactivation of X chromosome hsa03013 RNA transport EIF1AD 457.050527266419 474.533851566196 439.567202966641 0.926313689773347 -0.11042725988588 0.545322281316977 1 5.26021 4.88096 5.04852 4.60806 GeneID:84285,Genbank:NM_001242486.1,HGNC:HGNC:28147 eukaryotic translation initiation factor 1A domain containing GO:0003743,GO:0005634 translation initiation factor activity|nucleus EIF1AX 1154.39316132234 1234.8310633982 1073.95525924649 0.869718369645649 -0.201379788745737 0.1853216212479 1 12.7786 12.5059 11.6776 10.6164 GeneID:1964,Genbank:NM_001412.3,HGNC:HGNC:3250,MIM:300186 eukaryotic translation initiation factor 1A, X-linked GO:0003723,GO:0003743,GO:0005829,GO:0006413,GO:0008135 RNA binding|translation initiation factor activity|cytosol|translational initiation|translation factor activity, RNA binding hsa03013 RNA transport EIF1B 877.307762147867 873.579123922453 881.036400373282 1.0085364636661 0.0122632455763196 0.93660952236822 1 40.4303 41.935 41.666 42.095 GeneID:10289,Genbank:NM_005875.2,HGNC:HGNC:30792 eukaryotic translation initiation factor 1B GO:0003723,GO:0003743,GO:0006446 RNA binding|translation initiation factor activity|regulation of translational initiation hsa03013 RNA transport EIF2A 733.468005506208 795.225534539068 671.710476473347 0.844679210235229 -0.24352455192145 0.141656481436763 1 6.34381 5.51653 5.31003 4.90743 GeneID:83939,Genbank:NM_032025.4,HGNC:HGNC:3254,MIM:609234 eukaryotic translation initiation factor 2A GO:0000049,GO:0003729,GO:0003743,GO:0005615,GO:0005737,GO:0005850,GO:0006417,GO:0006468,GO:0009967,GO:0022627,GO:0032933,GO:0042255,GO:0043022,GO:0045296,GO:0072562,GO:1990928 tRNA binding|mRNA binding|translation initiation factor activity|extracellular space|cytoplasm|eukaryotic translation initiation factor 2 complex|regulation of translation|protein phosphorylation|positive regulation of signal transduction|cytosolic small ribosomal subunit|SREBP signaling pathway|ribosome assembly|ribosome binding|cadherin binding|blood microparticle|response to amino acid starvation EIF2AK1 5546.23302370059 5468.77756214525 5623.68848525592 1.02832642603403 0.0402982980604239 0.757936384057789 1 40.2644 39.8326 43.1072 40.1169 GeneID:27102,Genbank:NM_001134335.1,HGNC:HGNC:24921,MIM:613635 eukaryotic translation initiation factor 2 alpha kinase 1 GO:0002526,GO:0004694,GO:0005524,GO:0005737,GO:0006909,GO:0006950,GO:0008285,GO:0009605,GO:0010999,GO:0020037,GO:0030225,GO:0042803,GO:0045993,GO:0046501,GO:0046777,GO:0046986,GO:0055072 acute inflammatory response|eukaryotic translation initiation factor 2alpha kinase activity|ATP binding|cytoplasm|phagocytosis|response to stress|negative regulation of cell proliferation|response to external stimulus|regulation of eIF2 alpha phosphorylation by heme|heme binding|macrophage differentiation|protein homodimerization activity|negative regulation of translational initiation by iron|protoporphyrinogen IX metabolic process|protein autophosphorylation|negative regulation of hemoglobin biosynthetic process|iron ion homeostasis hsa04141,hsa05160,hsa05162,hsa05164,hsa05168 Protein processing in endoplasmic reticulum|Hepatitis C|Measles|Influenza A|Herpes simplex infection EIF2AK2 1688.50311610626 1407.99468807425 1969.01154413828 1.39845097486223 0.483829678509934 0.588589175980291 1 5.3265 4.66248 11.0517 3.22259 GeneID:5610,Genbank:XM_011532987.2,HGNC:HGNC:9437,MIM:176871 eukaryotic translation initiation factor 2 alpha kinase 2 hsa04141,hsa04217,hsa05160,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05203 Protein processing in endoplasmic reticulum|Necroptosis|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Viral carcinogenesis EIF2AK3 449.800159725141 453.210841253497 446.389478196784 0.984948808731392 -0.0218793503270141 0.941056419851686 1 3.18159 2.80177 3.46531 2.50804 GeneID:9451,Genbank:NM_004836.6,HGNC:HGNC:3255,MIM:604032 eukaryotic translation initiation factor 2 alpha kinase 3 GO:0001501,GO:0001503,GO:0001525,GO:0002063,GO:0004672,GO:0004674,GO:0004694,GO:0005524,GO:0005737,GO:0005783,GO:0005789,GO:0006468,GO:0006919,GO:0006983,GO:0007029,GO:0010575,GO:0010628,GO:0010998,GO:0016020,GO:0017148,GO:0018105,GO:0019722,GO:0019899,GO:0019903,GO:0030176,GO:0030282,GO:0030968,GO:0031018,GO:0031642,GO:0032057,GO:0034198,GO:0034976,GO:0036492,GO:0036499,GO:0042149,GO:0042802,GO:0042803,GO:0045943,GO:0046777,GO:0048009,GO:0048471,GO:0051260,GO:0051879,GO:0060734,GO:0070417,GO:1900182,GO:1902235,GO:1990737 skeletal system development|ossification|angiogenesis|chondrocyte development|protein kinase activity|protein serine/threonine kinase activity|eukaryotic translation initiation factor 2alpha kinase activity|ATP binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|protein phosphorylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|ER overload response|endoplasmic reticulum organization|positive regulation of vascular endothelial growth factor production|positive regulation of gene expression|regulation of translational initiation by eIF2 alpha phosphorylation|membrane|negative regulation of translation|peptidyl-serine phosphorylation|calcium-mediated signaling|enzyme binding|protein phosphatase binding|integral component of endoplasmic reticulum membrane|bone mineralization|endoplasmic reticulum unfolded protein response|endocrine pancreas development|negative regulation of myelination|negative regulation of translational initiation in response to stress|cellular response to amino acid starvation|response to endoplasmic reticulum stress|eiF2alpha phosphorylation in response to endoplasmic reticulum stress|PERK-mediated unfolded protein response|cellular response to glucose starvation|identical protein binding|protein homodimerization activity|positive regulation of transcription from RNA polymerase I promoter|protein autophosphorylation|insulin-like growth factor receptor signaling pathway|perinuclear region of cytoplasm|protein homooligomerization|Hsp90 protein binding|regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|cellular response to cold|positive regulation of protein localization to nucleus|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|response to manganese-induced endoplasmic reticulum stress hsa04137,hsa04140,hsa04141,hsa04210,hsa04932,hsa05010,hsa05160,hsa05162,hsa05164,hsa05168 Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Hepatitis C|Measles|Influenza A|Herpes simplex infection EIF2AK4 2501.34382740942 2547.90985497531 2454.77779984354 0.963447664779072 -0.0537217945463047 0.705949829090023 1 14.2174 13.6619 14.9097 12.4112 GeneID:440275,Genbank:XM_005254392.3,HGNC:HGNC:19687,MIM:609280 eukaryotic translation initiation factor 2 alpha kinase 4 GO:0000049,GO:0000077,GO:0002230,GO:0002250,GO:0002286,GO:0002821,GO:0004674,GO:0004694,GO:0005524,GO:0005844,GO:0006446,GO:0006468,GO:0007050,GO:0007612,GO:0007616,GO:0010998,GO:0019081,GO:0022626,GO:0032057,GO:0032792,GO:0034198,GO:0034644,GO:0036492,GO:0039520,GO:0044828,GO:0045665,GO:0045947,GO:0046777,GO:0051607,GO:0060259,GO:0060733,GO:0070417,GO:0071264,GO:1900273,GO:1990138,GO:1990253 tRNA binding|DNA damage checkpoint|positive regulation of defense response to virus by host|adaptive immune response|T cell activation involved in immune response|positive regulation of adaptive immune response|protein serine/threonine kinase activity|eukaryotic translation initiation factor 2alpha kinase activity|ATP binding|polysome|regulation of translational initiation|protein phosphorylation|cell cycle arrest|learning|long-term memory|regulation of translational initiation by eIF2 alpha phosphorylation|viral translation|cytosolic ribosome|negative regulation of translational initiation in response to stress|negative regulation of CREB transcription factor activity|cellular response to amino acid starvation|cellular response to UV|eiF2alpha phosphorylation in response to endoplasmic reticulum stress|induction by virus of host autophagy|negative regulation by host of viral genome replication|negative regulation of neuron differentiation|negative regulation of translational initiation|protein autophosphorylation|defense response to virus|regulation of feeding behavior|regulation of eIF2 alpha phosphorylation by amino acid starvation|cellular response to cold|positive regulation of translational initiation in response to starvation|positive regulation of long-term synaptic potentiation|neuron projection extension|cellular response to leucine starvation hsa04140,hsa04141,hsa05160,hsa05162,hsa05164,hsa05168 Autophagy - animal|Protein processing in endoplasmic reticulum|Hepatitis C|Measles|Influenza A|Herpes simplex infection EIF2B1 1145.0561293401 1147.84153622578 1142.27072245442 0.995146704840741 -0.00701887099523179 0.96117759649823 1 22.1368 22.9534 23.2867 22.088 GeneID:1967,Genbank:NM_001414.3,HGNC:HGNC:3257,MIM:606686 eukaryotic translation initiation factor 2B subunit alpha hsa03013 RNA transport EIF2B2 1048.61116172841 976.329405198373 1120.89291825845 1.14806837967837 0.199208572401204 0.19188225515325 1 22.4137 22.5797 25.364 26.8302 GeneID:8892,Genbank:NM_014239.3,HGNC:HGNC:3258,MIM:606454 eukaryotic translation initiation factor 2B subunit beta hsa03013 RNA transport EIF2B3 648.608665903625 648.84233218129 648.374999625959 0.999279744042347 -0.00103948409053512 1 1 6.03047 6.40945 6.21224 7.16848 GeneID:8891,Genbank:NM_001261418.1,HGNC:HGNC:3259,MIM:606273 eukaryotic translation initiation factor 2B subunit gamma hsa03013 RNA transport EIF2B4 908.105563768653 931.77315924154 884.437968295766 0.949198803940323 -0.0752178122552612 0.605648122919488 1 13.0946 14.9044 13.7104 13.0758 GeneID:8890,Genbank:NM_001318967.1,HGNC:HGNC:3260,MIM:606687 eukaryotic translation initiation factor 2B subunit delta hsa03013 RNA transport EIF2B5 2739.5251237577 2830.15850553486 2648.89174198054 0.935951727367984 -0.0954939715773306 0.483716557424845 1 28.2286 28.4208 26.3258 27.9677 GeneID:8893,Genbank:NM_003907.2,HGNC:HGNC:3261,MIM:603945 eukaryotic translation initiation factor 2B subunit epsilon hsa03013 RNA transport EIF2D 1168.59240703424 1067.03962383432 1270.14519023416 1.19034491490579 0.251379670107776 0.0967161398917898 1 5.32447 6.16182 6.84016 7.31412 GeneID:1939,Genbank:XM_011509257.2,HGNC:HGNC:6583,MIM:613709 eukaryotic translation initiation factor 2D GO:0001731,GO:0003743,GO:0004872,GO:0005737,GO:0005829,GO:0006886,GO:0016604,GO:0032790,GO:0075522 formation of translation preinitiation complex|translation initiation factor activity|receptor activity|cytoplasm|cytosol|intracellular protein transport|nuclear body|ribosome disassembly|IRES-dependent viral translational initiation EIF2S1 2075.63485976721 2289.31112722526 1861.95859230917 0.813327017968914 -0.298092555203857 0.0339994148426744 0.729079834868512 19.7634 20.7055 16.9102 15.7849 GeneID:1965,Genbank:NM_004094.4,HGNC:HGNC:3265,MIM:603907 eukaryotic translation initiation factor 2 subunit alpha GO:0003723,GO:0003743,GO:0005634,GO:0005829,GO:0005840,GO:0005844,GO:0005850,GO:0006413,GO:0007568,GO:0010494,GO:0016020,GO:0032057,GO:0033290,GO:0034198,GO:0034605,GO:0034644,GO:0034976,GO:0036499,GO:0043022,GO:0043614,GO:0044207,GO:0046777,GO:0055085,GO:0070062,GO:0097451,GO:1901216,GO:1905098,GO:1990737,GO:2000676 RNA binding|translation initiation factor activity|nucleus|cytosol|ribosome|polysome|eukaryotic translation initiation factor 2 complex|translational initiation|aging|cytoplasmic stress granule|membrane|negative regulation of translational initiation in response to stress|eukaryotic 48S preinitiation complex|cellular response to amino acid starvation|cellular response to heat|cellular response to UV|response to endoplasmic reticulum stress|PERK-mediated unfolded protein response|ribosome binding|multi-eIF complex|translation initiation ternary complex|protein autophosphorylation|transmembrane transport|extracellular exosome|glial limiting end-foot|positive regulation of neuron death|negative regulation of guanyl-nucleotide exchange factor activity|response to manganese-induced endoplasmic reticulum stress|positive regulation of type B pancreatic cell apoptotic process hsa03013,hsa04140,hsa04141,hsa04210,hsa04932,hsa05160,hsa05162,hsa05164,hsa05168 RNA transport|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease (NAFLD)|Hepatitis C|Measles|Influenza A|Herpes simplex infection EIF2S2 2565.40729331397 2759.49115410277 2371.32343252516 0.859333587280941 -0.218709810680746 0.116381960727838 1 25.8419 24.2726 22.4209 21.2825 GeneID:8894,Genbank:NM_001316363.1,HGNC:HGNC:3266,MIM:603908 eukaryotic translation initiation factor 2 subunit beta GO:0001701,GO:0002176,GO:0003723,GO:0003743,GO:0005737,GO:0005829,GO:0005850,GO:0006413,GO:0008135,GO:0008584,GO:0046872,GO:0055085 in utero embryonic development|male germ cell proliferation|RNA binding|translation initiation factor activity|cytoplasm|cytosol|eukaryotic translation initiation factor 2 complex|translational initiation|translation factor activity, RNA binding|male gonad development|metal ion binding|transmembrane transport hsa03013 RNA transport EIF2S3 2756.1580705307 3216.74601108491 2295.57012997649 0.713631142174716 -0.486749520435353 0.000444752574881586 0.0588690680934172 41.825 38.3714 27.4677 29.514 GeneID:1968,Genbank:NM_001415.3,HGNC:HGNC:3267,MIM:300161 eukaryotic translation initiation factor 2 subunit gamma GO:0003743,GO:0003924,GO:0005525,GO:0005737,GO:0005829,GO:0005850,GO:0006413,GO:0008135,GO:0045296,GO:0055085,GO:0070062 translation initiation factor activity|GTPase activity|GTP binding|cytoplasm|cytosol|eukaryotic translation initiation factor 2 complex|translational initiation|translation factor activity, RNA binding|cadherin binding|transmembrane transport|extracellular exosome hsa03013 RNA transport EIF2S3B 105.200436050871 128.51132616985 81.889545931892 0.637216565827517 -0.650144321548079 0.0415580781660379 0.762843764469236 2.21654 1.79098 1.06134 1.47307 GeneID:255308,Genbank:NM_001357731.1,HGNC:HGNC:43863 eukaryotic translation initiation factor 2 subunit gamma B GO:0003743,GO:0003924,GO:0005525 translation initiation factor activity|GTPase activity|GTP binding EIF3A 3872.79042793947 4137.04256332502 3608.53829255392 0.872250705019013 -0.197185236371957 0.384301887878227 1 19.4715 17.2776 19.0468 13.4745 GeneID:8661,Genbank:NM_003750.3,HGNC:HGNC:3271,MIM:602039 eukaryotic translation initiation factor 3 subunit A hsa03013 RNA transport EIF3B 11537.8889180483 11296.5579648629 11779.2198712338 1.04272645772918 0.060360739989513 0.653735643730872 1 109.117 113.863 119.405 117.096 GeneID:8662,Genbank:XM_011515599.1,HGNC:HGNC:3280,MIM:603917 eukaryotic translation initiation factor 3 subunit B GO:0003723,GO:0003743,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0031369,GO:0032947,GO:0070062,GO:0071541,GO:0075522,GO:0075525 RNA binding|translation initiation factor activity|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|translation initiation factor binding|protein complex scaffold activity|extracellular exosome|eukaryotic translation initiation factor 3 complex, eIF3m|IRES-dependent viral translational initiation|viral translational termination-reinitiation hsa03013 RNA transport EIF3C 908.864582577766 772.825311872229 1044.9038532833 1.35205697488342 0.435155947219114 0.599210305310504 1 8.20074 5.23978 4.94056 13.0614 GeneID:8663,Genbank:NM_001199142.1,HGNC:HGNC:3279,MIM:603916 eukaryotic translation initiation factor 3 subunit C hsa03013 RNA transport EIF3CL 56.5518960632274 52.0426041559955 61.0611879704592 1.17329232387047 0.23056250326984 0.548368057146756 1 0.282183 0.217171 0.256394 0.164496 GeneID:728689,Genbank:NM_001317857.1,HGNC:HGNC:26347 eukaryotic translation initiation factor 3 subunit C like GO:0003743,GO:0005852,GO:0006413,GO:0031369 translation initiation factor activity|eukaryotic translation initiation factor 3 complex|translational initiation|translation initiation factor binding hsa03013 RNA transport EIF3D 4812.07096785327 4976.38266004709 4647.75927565945 0.933963401362602 -0.0985620778295098 0.45412297174701 1 70.1399 72.6569 63.7987 70.1154 GeneID:8664,Genbank:NM_003753.3,HGNC:HGNC:3278,MIM:603915 eukaryotic translation initiation factor 3 subunit D GO:0001732,GO:0002191,GO:0003723,GO:0003743,GO:0005829,GO:0005852,GO:0006413,GO:0016020,GO:0045727,GO:0071541,GO:0075522,GO:0075525,GO:0098808,GO:1902416 formation of cytoplasmic translation initiation complex|cap-dependent translational initiation|RNA binding|translation initiation factor activity|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|membrane|positive regulation of translation|eukaryotic translation initiation factor 3 complex, eIF3m|IRES-dependent viral translational initiation|viral translational termination-reinitiation|mRNA cap binding|positive regulation of mRNA binding hsa03013 RNA transport EIF3E 2378.23964774488 2648.7850775368 2107.69421795296 0.795721116004238 -0.329665210671462 0.0182561528830924 0.551680272784165 49.705 48.298 41.7391 36.9226 GeneID:3646,Genbank:NM_001568.2,HGNC:HGNC:3277,MIM:602210 eukaryotic translation initiation factor 3 subunit E GO:0000184,GO:0003723,GO:0003743,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0016020,GO:0016604,GO:0016605,GO:0045296,GO:0045727,GO:0045947,GO:0047485,GO:0070062,GO:1902416 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|translation initiation factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|membrane|nuclear body|PML body|cadherin binding|positive regulation of translation|negative regulation of translational initiation|protein N-terminus binding|extracellular exosome|positive regulation of mRNA binding hsa03013,hsa05160 RNA transport|Hepatitis C EIF3F 1825.72979897128 1695.58914878322 1955.87044915933 1.15350493400061 0.206024175016118 0.156511985717106 1 54.9652 62.2507 66.917 70.0021 GeneID:8665,Genbank:NM_003754.2,HGNC:HGNC:3275,MIM:603914 eukaryotic translation initiation factor 3 subunit F hsa03013 RNA transport EIF3G 4317.76128451834 4375.81929928786 4259.70326974882 0.973464162572266 -0.0388002268107744 0.749427876658286 1 105.671 113.391 105.489 109.863 GeneID:8666,Genbank:NM_003755.4,HGNC:HGNC:3274,MIM:603913 eukaryotic translation initiation factor 3 subunit G GO:0003723,GO:0003743,GO:0005737,GO:0005829,GO:0005852,GO:0006413,GO:0048471,GO:0075525 RNA binding|translation initiation factor activity|cytoplasm|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|perinuclear region of cytoplasm|viral translational termination-reinitiation hsa03013 RNA transport EIF3H 2524.24152548636 2637.47623467306 2411.00681629965 0.914134043978794 -0.129522364610247 0.352126684499353 1 70.5648 68.9081 65.1178 63.2396 GeneID:8667,Genbank:NM_003756.2,HGNC:HGNC:3273,MIM:603912 eukaryotic translation initiation factor 3 subunit H GO:0003723,GO:0003743,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0016020,GO:0070062,GO:0071541 RNA binding|translation initiation factor activity|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|membrane|extracellular exosome|eukaryotic translation initiation factor 3 complex, eIF3m hsa03013,hsa05162 RNA transport|Measles EIF3I 8749.96599338062 9063.62263217124 8436.30935459 0.930787798318676 -0.10347579628475 0.433671015375322 1 160.69 170.205 146.427 164.06 GeneID:8668,Genbank:NM_003757.3,HGNC:HGNC:3272,MIM:603911 eukaryotic translation initiation factor 3 subunit I GO:0003743,GO:0005829,GO:0005852,GO:0006413,GO:0070062,GO:0071541 translation initiation factor activity|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|extracellular exosome|eukaryotic translation initiation factor 3 complex, eIF3m hsa03013 RNA transport EIF3J 1616.54327075059 1832.41882912867 1400.66771237251 0.764381859707556 -0.38763455417075 0.00725725130744411 0.338869203906778 28.2785 28.156 23.5671 19.497 GeneID:8669,Genbank:NM_003758.3,HGNC:HGNC:3270,MIM:603910 eukaryotic translation initiation factor 3 subunit J GO:0003743,GO:0005829,GO:0005852,GO:0006413 translation initiation factor activity|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation hsa03013 RNA transport EIF3K 4767.58608906398 4614.20063804382 4920.97154008414 1.06648408383264 0.0928624351139587 0.612812124890084 1 183.226 192.666 192.674 224.616 GeneID:27335,Genbank:NM_001308393.1,HGNC:HGNC:24656,MIM:609596 eukaryotic translation initiation factor 3 subunit K GO:0003743,GO:0005634,GO:0005829,GO:0005852,GO:0006413,GO:0006446,GO:0016020,GO:0043022,GO:0070062 translation initiation factor activity|nucleus|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|regulation of translational initiation|membrane|ribosome binding|extracellular exosome EIF3L 4633.20663894014 4880.68446649646 4385.72881138382 0.898588884712735 -0.154266878640294 0.247098590414217 1 67.2522 67.2088 59.6715 61.9583 GeneID:51386,Genbank:XM_006724260.4,HGNC:HGNC:18138 eukaryotic translation initiation factor 3 subunit L GO:0001650,GO:0003723,GO:0003743,GO:0005654,GO:0005829,GO:0005852,GO:0006413,GO:0016020,GO:0075525 fibrillar center|RNA binding|translation initiation factor activity|nucleoplasm|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|membrane|viral translational termination-reinitiation EIF3M 3382.08345042534 3700.81580135493 3063.35109949575 0.827750221552289 -0.272732603119095 0.0442009642187769 0.784836632957795 66.4164 70.1017 58.6674 54.4794 GeneID:10480,Genbank:NM_006360.5,HGNC:HGNC:24460,MIM:609641 eukaryotic translation initiation factor 3 subunit M GO:0002183,GO:0003743,GO:0005829,GO:0005852,GO:0006413,GO:0031369,GO:0071541 cytoplasmic translational initiation|translation initiation factor activity|cytosol|eukaryotic translation initiation factor 3 complex|translational initiation|translation initiation factor binding|eukaryotic translation initiation factor 3 complex, eIF3m EIF4A1 30480.4362788169 30468.0394585126 30492.8330991212 1.00081375897659 0.00117352862002111 0.999797372166644 1 495.422 517.52 498.698 529.862 GeneID:1973,Genbank:NM_001416.3,HGNC:HGNC:3282,MIM:602641 eukaryotic translation initiation factor 4A1 GO:0000289,GO:0000339,GO:0003723,GO:0003725,GO:0003729,GO:0003743,GO:0004004,GO:0004386,GO:0005524,GO:0005737,GO:0005829,GO:0006413,GO:0008135,GO:0010468,GO:0010501,GO:0016020,GO:0016032,GO:0016281,GO:0031012,GO:0070062 nuclear-transcribed mRNA poly(A) tail shortening|RNA cap binding|RNA binding|double-stranded RNA binding|mRNA binding|translation initiation factor activity|ATP-dependent RNA helicase activity|helicase activity|ATP binding|cytoplasm|cytosol|translational initiation|translation factor activity, RNA binding|regulation of gene expression|RNA secondary structure unwinding|membrane|viral process|eukaryotic translation initiation factor 4F complex|extracellular matrix|extracellular exosome hsa03013 RNA transport EIF4A2 6778.83468848363 7317.41372281063 6240.25565415663 0.852795248504786 -0.229728694991116 0.0838388441457616 0.963076417285947 124.865 123.097 101.482 111.101 GeneID:1974,Genbank:NM_001967.3,HGNC:HGNC:3284,MIM:601102 eukaryotic translation initiation factor 4A2 GO:0003743,GO:0004004,GO:0005524,GO:0005730,GO:0005737,GO:0006413,GO:0010468,GO:0010501,GO:0016887,GO:0048471,GO:1900260,GO:1990830 translation initiation factor activity|ATP-dependent RNA helicase activity|ATP binding|nucleolus|cytoplasm|translational initiation|regulation of gene expression|RNA secondary structure unwinding|ATPase activity|perinuclear region of cytoplasm|negative regulation of RNA-directed 5'-3' RNA polymerase activity|cellular response to leukemia inhibitory factor hsa03013 RNA transport EIF4A3 2850.51880477043 2894.17454574679 2806.86306379408 0.969831991618814 -0.0441932505276645 0.740832068733196 1 53.5982 55.066 54.4006 55.3828 GeneID:9775,Genbank:NM_014740.3,HGNC:HGNC:18683,MIM:608546 eukaryotic translation initiation factor 4A3 GO:0000184,GO:0000289,GO:0000398,GO:0003723,GO:0003729,GO:0004004,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006369,GO:0006405,GO:0006406,GO:0008143,GO:0008306,GO:0008380,GO:0010501,GO:0014070,GO:0016020,GO:0016607,GO:0017148,GO:0030425,GO:0031124,GO:0035145,GO:0035368,GO:0035613,GO:0035640,GO:0043021,GO:0043025,GO:0045727,GO:0048701,GO:0071013,GO:0072715,GO:0090394,GO:1904570,GO:1904574,GO:1990416 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|mRNA splicing, via spliceosome|RNA binding|mRNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|poly(A) binding|associative learning|RNA splicing|RNA secondary structure unwinding|response to organic cyclic compound|membrane|nuclear speck|negative regulation of translation|dendrite|mRNA 3'-end processing|exon-exon junction complex|selenocysteine insertion sequence binding|RNA stem-loop binding|exploration behavior|ribonucleoprotein complex binding|neuronal cell body|positive regulation of translation|embryonic cranial skeleton morphogenesis|catalytic step 2 spliceosome|cellular response to selenite ion|negative regulation of excitatory postsynaptic potential|negative regulation of selenocysteine incorporation|negative regulation of selenocysteine insertion sequence binding|cellular response to brain-derived neurotrophic factor stimulus hsa03013,hsa03015,hsa03040 RNA transport|mRNA surveillance pathway|Spliceosome EIF4B 5664.63933594863 6062.49954058729 5266.77913130996 0.868747139038917 -0.20299177324433 0.129220905059408 1 49.323 46.8103 42.0385 42.8129 GeneID:1975,Genbank:NM_001300821.2,HGNC:HGNC:3285,MIM:603928 eukaryotic translation initiation factor 4B GO:0000289,GO:0001731,GO:0003723,GO:0003743,GO:0004386,GO:0005829,GO:0005844,GO:0006413,GO:0006446,GO:0016281,GO:0033592,GO:0034057,GO:0043024,GO:0097010 nuclear-transcribed mRNA poly(A) tail shortening|formation of translation preinitiation complex|RNA binding|translation initiation factor activity|helicase activity|cytosol|polysome|translational initiation|regulation of translational initiation|eukaryotic translation initiation factor 4F complex|RNA strand annealing activity|RNA strand-exchange activity|ribosomal small subunit binding|eukaryotic translation initiation factor 4F complex assembly hsa03013,hsa04150,hsa04151,hsa05205 RNA transport|mTOR signaling pathway|PI3K-Akt signaling pathway|Proteoglycans in cancer EIF4E 841.550902311626 904.279100455533 778.822704167719 0.86126363395481 -0.215473178773419 0.180088347011565 1 2.50711 2.14141 2.29013 1.91548 GeneID:1977,Genbank:NM_001968.4,HGNC:HGNC:3287,MIM:133440 eukaryotic translation initiation factor 4E hsa01521,hsa03013,hsa04066,hsa04150,hsa04151,hsa04211,hsa04910 EGFR tyrosine kinase inhibitor resistance|RNA transport|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Longevity regulating pathway|Insulin signaling pathway EIF4E2 1768.26635985269 1708.09864851408 1828.43407119129 1.07044992558357 0.0982173096870506 0.498633977836108 1 13.332 13.9426 14.8736 15.4079 GeneID:9470,Genbank:NM_001282958.1,HGNC:HGNC:3293,MIM:605895 eukaryotic translation initiation factor 4E family member 2 GO:0000339,GO:0001701,GO:0003723,GO:0003743,GO:0005829,GO:0005845,GO:0008135,GO:0017148,GO:0031625 RNA cap binding|in utero embryonic development|RNA binding|translation initiation factor activity|cytosol|mRNA cap binding complex|translation factor activity, RNA binding|negative regulation of translation|ubiquitin protein ligase binding hsa01521,hsa03013,hsa04066,hsa04150,hsa04151,hsa04211,hsa04910 EGFR tyrosine kinase inhibitor resistance|RNA transport|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Longevity regulating pathway|Insulin signaling pathway EIF4E3 145.858548413555 148.738523819049 142.97857300806 0.961274653915508 -0.0569794003819192 0.851478107251023 1 1.10389 1.01804 1.05528 0.833132 GeneID:317649,Genbank:NM_173359.4,HGNC:HGNC:31837,MIM:609896 eukaryotic translation initiation factor 4E family member 3 GO:0003743,GO:0005829,GO:0005845,GO:0006417 translation initiation factor activity|cytosol|mRNA cap binding complex|regulation of translation EIF4EBP1 2107.03130492278 2296.56040505356 1917.50220479201 0.834945251417106 -0.260246493825916 0.170638627378964 1 104.181 115.523 86.2046 100.301 GeneID:1978,Genbank:NM_004095.3,HGNC:HGNC:3288,MIM:602223 eukaryotic translation initiation factor 4E binding protein 1 hsa01521,hsa03013,hsa04012,hsa04066,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04910,hsa05163,hsa05165,hsa05221,hsa05231 EGFR tyrosine kinase inhibitor resistance|RNA transport|ErbB signaling pathway|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Insulin signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Acute myeloid leukemia|Choline metabolism in cancer EIF4EBP2 3544.68254635003 3603.6778365646 3485.68725613546 0.967258288398603 -0.0480269087682845 0.723749033518602 1 22.7428 23.3684 24.8268 20.3807 GeneID:1979,Genbank:NM_004096.4,HGNC:HGNC:3289,MIM:602224 eukaryotic translation initiation factor 4E binding protein 2 hsa03013,hsa04213 RNA transport|Longevity regulating pathway - multiple species EIF4EBP3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 6.69051e-15 2.37159e-19 0.000340535 9.34874e-05 GeneID:8637,Genbank:NM_003732.2,HGNC:HGNC:3290,MIM:603483 eukaryotic translation initiation factor 4E binding protein 3 GO:0005737,GO:0008190,GO:0016020,GO:0016281,GO:0030371,GO:0045947 cytoplasm|eukaryotic initiation factor 4E binding|membrane|eukaryotic translation initiation factor 4F complex|translation repressor activity|negative regulation of translational initiation hsa03013 RNA transport EIF4ENIF1 548.477619424937 546.467469448596 550.487769401278 1.00735688797128 0.0105748941582132 0.953839205962511 1 2.85733 2.96951 2.78811 3.1999 GeneID:56478,Genbank:XM_011530280.2,HGNC:HGNC:16687,MIM:607445 eukaryotic translation initiation factor 4E nuclear import factor 1 GO:0000932,GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0005829,GO:0008565,GO:0016020,GO:0016605,GO:0016607,GO:0017148,GO:0019827,GO:0043231,GO:0045665 P-body|RNA binding|mRNA binding|nucleus|cytoplasm|cytosol|protein transporter activity|membrane|PML body|nuclear speck|negative regulation of translation|stem cell population maintenance|intracellular membrane-bounded organelle|negative regulation of neuron differentiation EIF4G1 25071.062278859 25121.3495443862 25020.7750133318 0.995996451907301 -0.00578749197639444 0.950292133498425 1 119.461 124.012 128.466 118.88 GeneID:1981,Genbank:NM_001194946.1,HGNC:HGNC:3296,MIM:600495 eukaryotic translation initiation factor 4 gamma 1 GO:0000184,GO:0000289,GO:0001662,GO:0002191,GO:0003723,GO:0003729,GO:0003743,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0006412,GO:0006413,GO:0006446,GO:0007005,GO:0008135,GO:0008190,GO:0008284,GO:0010507,GO:0010801,GO:0010942,GO:0016020,GO:0016032,GO:0016281,GO:0030307,GO:0031369,GO:0032270,GO:0032502,GO:0032947,GO:0033138,GO:0034645,GO:0042802,GO:0043488,GO:0045296,GO:0045666,GO:0060964,GO:0080135,GO:1900087,GO:1901215,GO:1905537,GO:1905606,GO:1905612,GO:1905618,GO:1905696,GO:2000507 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|behavioral fear response|cap-dependent translational initiation|RNA binding|mRNA binding|translation initiation factor activity|ATP binding|nucleus|cytoplasm|cytosol|polysome|translation|translational initiation|regulation of translational initiation|mitochondrion organization|translation factor activity, RNA binding|eukaryotic initiation factor 4E binding|positive regulation of cell proliferation|negative regulation of autophagy|negative regulation of peptidyl-threonine phosphorylation|positive regulation of cell death|membrane|viral process|eukaryotic translation initiation factor 4F complex|positive regulation of cell growth|translation initiation factor binding|positive regulation of cellular protein metabolic process|developmental process|protein complex scaffold activity|positive regulation of peptidyl-serine phosphorylation|cellular macromolecule biosynthetic process|identical protein binding|regulation of mRNA stability|cadherin binding|positive regulation of neuron differentiation|regulation of gene silencing by miRNA|regulation of cellular response to stress|positive regulation of G1/S transition of mitotic cell cycle|negative regulation of neuron death|positive regulation of eukaryotic translation initiation factor 4F complex assembly|regulation of presynapse assembly|positive regulation of mRNA cap binding|positive regulation of miRNA mediated inhibition of translation|regulation of polysome binding|positive regulation of energy homeostasis hsa03013,hsa05416 RNA transport|Viral myocarditis EIF4G2 12852.3069842413 13205.1116603783 12499.5023081042 0.946565438413424 -0.0792258484289178 0.557280104334332 1 104.954 97.7409 108.454 86.2359 GeneID:1982,Genbank:NM_001042559.2,HGNC:HGNC:3297,MIM:602325 eukaryotic translation initiation factor 4 gamma 2 GO:0003723,GO:0003743,GO:0005829,GO:0005913,GO:0006446,GO:0007050,GO:0008135,GO:0008219,GO:0010507,GO:0016020,GO:0016281,GO:0030307,GO:0034645,GO:0045296 RNA binding|translation initiation factor activity|cytosol|cell-cell adherens junction|regulation of translational initiation|cell cycle arrest|translation factor activity, RNA binding|cell death|negative regulation of autophagy|membrane|eukaryotic translation initiation factor 4F complex|positive regulation of cell growth|cellular macromolecule biosynthetic process|cadherin binding hsa03013,hsa05416 RNA transport|Viral myocarditis EIF4G3 1558.02168657491 1605.28951530751 1510.75385784231 0.941109901632232 -0.0875648859807907 0.604741937327544 1 4.49149 4.63924 5.13609 3.76782 GeneID:8672,Genbank:NM_001198801.1,HGNC:HGNC:3298,MIM:603929 eukaryotic translation initiation factor 4 gamma 3 GO:0000339,GO:0003723,GO:0003743,GO:0005829,GO:0006446,GO:0008135,GO:0016032,GO:0016281 RNA cap binding|RNA binding|translation initiation factor activity|cytosol|regulation of translational initiation|translation factor activity, RNA binding|viral process|eukaryotic translation initiation factor 4F complex hsa03013,hsa05416 RNA transport|Viral myocarditis EIF4H 15734.0125464133 16120.1333830478 15347.8917097788 0.952094585390893 -0.0708231903709656 0.578582800448944 1 208.091 211.317 206.506 204.568 GeneID:7458,Genbank:NM_022170.1,HGNC:HGNC:12741,MIM:603431 eukaryotic translation initiation factor 4H GO:0001731,GO:0003723,GO:0003743,GO:0004386,GO:0005829,GO:0005844,GO:0006413,GO:0006446,GO:0008135,GO:0016020,GO:0016032,GO:0016281,GO:0019953,GO:0033592,GO:0034057,GO:0043024,GO:0045296,GO:0048471,GO:0048589,GO:0097010 formation of translation preinitiation complex|RNA binding|translation initiation factor activity|helicase activity|cytosol|polysome|translational initiation|regulation of translational initiation|translation factor activity, RNA binding|membrane|viral process|eukaryotic translation initiation factor 4F complex|sexual reproduction|RNA strand annealing activity|RNA strand-exchange activity|ribosomal small subunit binding|cadherin binding|perinuclear region of cytoplasm|developmental growth|eukaryotic translation initiation factor 4F complex assembly EIF5 3048.84810175764 3376.23871378341 2721.45748973187 0.806061928803074 -0.311037411289352 0.0308258880077888 0.695369080690778 21.9438 21.1291 19.8516 15.1888 GeneID:1983,Genbank:NM_001969.4,HGNC:HGNC:3299,MIM:601710 eukaryotic translation initiation factor 5 GO:0003723,GO:0003743,GO:0003924,GO:0005525,GO:0005737,GO:0005829,GO:0005886,GO:0006413,GO:0006446,GO:0008135,GO:0045296 RNA binding|translation initiation factor activity|GTPase activity|GTP binding|cytoplasm|cytosol|plasma membrane|translational initiation|regulation of translational initiation|translation factor activity, RNA binding|cadherin binding hsa03013 RNA transport EIF5A 16389.7178098687 16737.4136611068 16042.0219586305 0.958452857976963 -0.0612206209860267 0.614559799912937 1 122.445 136.822 127.819 134.808 GeneID:1984,Genbank:NM_001143760.1,HGNC:HGNC:3300,MIM:600187 eukaryotic translation initiation factor 5A GO:0003746,GO:0005643,GO:0005789,GO:0006452,GO:0015031,GO:0043022,GO:0043065,GO:0045901,GO:0045905,GO:0051028 translation elongation factor activity|nuclear pore|endoplasmic reticulum membrane|translational frameshifting|protein transport|ribosome binding|positive regulation of apoptotic process|positive regulation of translational elongation|positive regulation of translational termination|mRNA transport EIF5A2 471.521377579263 496.173428491474 446.869326667051 0.900631313582584 -0.150991456020677 0.401152538701297 1 4.54416 4.60153 4.61173 3.60618 GeneID:56648,Genbank:NM_020390.5,HGNC:HGNC:3301,MIM:605782 eukaryotic translation initiation factor 5A2 GO:0003746,GO:0005643,GO:0005789,GO:0005829,GO:0006452,GO:0007283,GO:0008284,GO:0008612,GO:0010509,GO:0015031,GO:0043022,GO:0043231,GO:0045901,GO:0045905,GO:0051028 translation elongation factor activity|nuclear pore|endoplasmic reticulum membrane|cytosol|translational frameshifting|spermatogenesis|positive regulation of cell proliferation|peptidyl-lysine modification to peptidyl-hypusine|polyamine homeostasis|protein transport|ribosome binding|intracellular membrane-bounded organelle|positive regulation of translational elongation|positive regulation of translational termination|mRNA transport EIF5AL1 486.774291760014 528.700437464292 444.848146055736 0.841399239594502 -0.24913758060017 0.15558066988827 1 4.519 4.78867 3.64333 3.81286 GeneID:143244,Genbank:NM_001099692.1,HGNC:HGNC:17419 eukaryotic translation initiation factor 5A-like 1 GO:0003746,GO:0005643,GO:0005789,GO:0006452,GO:0015031,GO:0043022,GO:0045901,GO:0045905,GO:0051028 translation elongation factor activity|nuclear pore|endoplasmic reticulum membrane|translational frameshifting|protein transport|ribosome binding|positive regulation of translational elongation|positive regulation of translational termination|mRNA transport EIF5B 516.443369124769 543.342710591511 489.544027658028 0.900985728004126 -0.150423841568579 0.696251583674196 1 3.34354 2.44172 3.17287 2.1493 GeneID:9669,Genbank:NM_015904.3,HGNC:HGNC:30793,MIM:606086 eukaryotic translation initiation factor 5B GO:0003723,GO:0003743,GO:0003924,GO:0005525,GO:0005737,GO:0005829,GO:0006446,GO:0046872 RNA binding|translation initiation factor activity|GTPase activity|GTP binding|cytoplasm|cytosol|regulation of translational initiation|metal ion binding hsa03013 RNA transport EIF6 3762.40667306168 3984.39465529972 3540.41869082363 0.888571288015975 -0.170440569909235 0.312873009759835 1 66.493 74.2095 60.7047 71.4516 GeneID:3692,Genbank:NM_002212.3,HGNC:HGNC:6159,MIM:602912 eukaryotic translation initiation factor 6 GO:0000054,GO:0000460,GO:0000470,GO:0003743,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006110,GO:0030687,GO:0032868,GO:0035195,GO:0035278,GO:0042256,GO:0042304,GO:0043022,GO:0043023,GO:0045652,GO:0045727,GO:0070062,GO:1902626,GO:2000377 ribosomal subunit export from nucleus|maturation of 5.8S rRNA|maturation of LSU-rRNA|translation initiation factor activity|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of glycolytic process|preribosome, large subunit precursor|response to insulin|gene silencing by miRNA|miRNA mediated inhibition of translation|mature ribosome assembly|regulation of fatty acid biosynthetic process|ribosome binding|ribosomal large subunit binding|regulation of megakaryocyte differentiation|positive regulation of translation|extracellular exosome|assembly of large subunit precursor of preribosome|regulation of reactive oxygen species metabolic process hsa03008 Ribosome biogenesis in eukaryotes EIPR1 745.275234854034 724.821999794043 765.728469914025 1.05643657357476 0.079206153230271 0.638284348096207 1 6.91156 7.53881 8.66896 7.88393 GeneID:7260,Genbank:NM_001330531.1,HGNC:HGNC:12383,MIM:608998 EARP complex and GARP complex interacting protein 1 ELAC1 52.8519460408168 48.525860448032 57.1780316336017 1.17830021159203 0.236707161065836 0.573026808754388 1 0.790731 0.942014 0.875299 1.06117 GeneID:55520,Genbank:NM_018696.2,HGNC:HGNC:14197,MIM:608079 elaC ribonuclease Z 1 GO:0005634,GO:0005829,GO:0042781,GO:0046872 nucleus|cytosol|3'-tRNA processing endoribonuclease activity|metal ion binding hsa03013 RNA transport ELAC2 4068.95063683021 4293.51266172093 3844.38861193948 0.895394730336854 -0.159404267308468 0.235186832230244 1 32.4907 31.9398 29.3234 29.5595 GeneID:60528,Genbank:NM_001165962.1,HGNC:HGNC:14198,MIM:605367 elaC ribonuclease Z 2 hsa03013 RNA transport ELANE 1.48672269415927 1.51824048055703 1.45520490776151 0.958481167112346 -0.0611780097655067 1 1 0.0367368 0.0311526 0 0 GeneID:1991,Genbank:XM_011527775.1,HGNC:HGNC:3309,MIM:130130 elastase, neutrophil expressed hsa05202,hsa05322 Transcriptional misregulation in cancer|Systemic lupus erythematosus ELAVL1 4121.94155560008 4285.2981347481 3958.58497645207 0.923759526636708 -0.114410757186718 0.389472666048127 1 29.9753 31.0794 30.2406 26.6903 GeneID:1994,Genbank:NM_001419.2,HGNC:HGNC:3312,MIM:603466 ELAV like RNA binding protein 1 hsa04152,hsa04657 AMPK signaling pathway|IL-17 signaling pathway ELAVL2 78.1163244146003 73.3459971584789 82.8866516707217 1.13007737138849 0.176421550956589 0.607433139370681 1 0.497608 0.463319 0.695239 0.406952 GeneID:1993,Genbank:XM_011517783.3,HGNC:HGNC:3313,MIM:601673 ELAV like RNA binding protein 2 GO:0003723 RNA binding ELAVL3 1.72795188737276 1.51824048055703 1.93766329418849 1.27625584945382 0.351917573411544 1 1 0.0078685 0.0138412 0.00731454 0.0205871 GeneID:1995,Genbank:XM_024451413.1,HGNC:HGNC:3314,MIM:603458 ELAV like RNA binding protein 3 GO:0007399,GO:0017091,GO:0030154 nervous system development|AU-rich element binding|cell differentiation ELF1 605.624984798497 590.861036272014 620.388933324981 1.04997435139618 0.0703540864004561 0.667713551111405 1 4.41766 4.42824 5.65094 4.01206 GeneID:1997,Genbank:NM_172373.3,HGNC:HGNC:3316,MIM:189973 E74 like ETS transcription factor 1 GO:0000978,GO:0001077,GO:0001817,GO:0001959,GO:0003700,GO:0005634,GO:0005654,GO:0030154,GO:0045893,GO:0045944,GO:0050855,GO:0050860 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|regulation of cytokine production|regulation of cytokine-mediated signaling pathway|DNA binding transcription factor activity|nucleus|nucleoplasm|cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of B cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway ELF2 266.866036411059 289.943680165106 243.788392657012 0.84081292104104 -0.250143255060869 0.23462187353929 1 2.21916 2.168 2.00006 1.60054 GeneID:1998,Genbank:NM_001331036.1,HGNC:HGNC:3317 E74 like ETS transcription factor 2 GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006357,GO:0016604,GO:0030154,GO:0043565,GO:0045892,GO:0045893,GO:0050855 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|nuclear body|cell differentiation|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of B cell receptor signaling pathway ELF3 99.9568118377308 136.919992243134 62.9936314323273 0.460076212394659 -1.1200552290731 0.00210902134941814 0.164715617601136 1.08519 1.49725 0.528981 0.773921 GeneID:1999,Genbank:NM_001114309.1,HGNC:HGNC:3318,MIM:602191 E74 like ETS transcription factor 3 GO:0000978,GO:0000981,GO:0001077,GO:0001824,GO:0003700,GO:0003713,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006357,GO:0006366,GO:0006954,GO:0007275,GO:0008544,GO:0030198,GO:0030855,GO:0045747,GO:0045892,GO:0045893,GO:0060056 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|blastocyst development|DNA binding transcription factor activity|transcription coactivator activity|nucleus|nucleoplasm|Golgi apparatus|cytosol|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|inflammatory response|multicellular organism development|epidermis development|extracellular matrix organization|epithelial cell differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|mammary gland involution ELF4 1972.53787704098 2173.26330851329 1771.81244556866 0.815277393506788 -0.294637083216058 0.0360656272050692 0.738653561785664 14.6973 14.6441 12.5974 12.0322 GeneID:2000,Genbank:NM_001127197.1,HGNC:HGNC:3319,MIM:300775 E74 like ETS transcription factor 4 GO:0000978,GO:0001077,GO:0001787,GO:0001866,GO:0005654,GO:0016604,GO:0016605,GO:0030154,GO:0045087,GO:0045893,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|natural killer cell proliferation|NK T cell proliferation|nucleoplasm|nuclear body|PML body|cell differentiation|innate immune response|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter ELF5 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0175605 0 0 0 GeneID:2001,Genbank:XM_017017308.1,HGNC:HGNC:3320,MIM:605169 E74 like ETS transcription factor 5 GO:0000977,GO:0000981,GO:0001228,GO:0001712,GO:0005634,GO:0005737,GO:0006357,GO:0006366,GO:0008283,GO:0030154,GO:0035019,GO:0045596,GO:0060644 RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|ectodermal cell fate commitment|nucleus|cytoplasm|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|cell proliferation|cell differentiation|somatic stem cell population maintenance|negative regulation of cell differentiation|mammary gland epithelial cell differentiation hsa04917 Prolactin signaling pathway ELFN1 1.21136579838783 0 2.42273159677566 Inf Inf 0.33960385030001 1 0 0 0.00909891 0.0127829 GeneID:392617,Genbank:XM_006715725.3,HGNC:HGNC:33154,MIM:614964 extracellular leucine rich repeat and fibronectin type III domain containing 1 GO:0004864,GO:0010923,GO:0016021,GO:0030425,GO:0050808,GO:0060076,GO:0070062 protein phosphatase inhibitor activity|negative regulation of phosphatase activity|integral component of membrane|dendrite|synapse organization|excitatory synapse|extracellular exosome ELFN2 262.737130201499 169.235278806996 356.238981596002 2.10499243483549 1.07381504837721 1.64035752819044e-05 0.00702715616170104 0.720945 0.864015 1.95866 1.45893 GeneID:114794,Genbank:NM_052906.4,HGNC:HGNC:29396 extracellular leucine rich repeat and fibronectin type III domain containing 2 GO:0004864,GO:0005615,GO:0010923,GO:0016021 protein phosphatase inhibitor activity|extracellular space|negative regulation of phosphatase activity|integral component of membrane ELK1 1268.77598507719 1236.34152922536 1301.21044092902 1.05246844028956 0.0737769727497327 0.630155786338783 1 16.3823 16.7607 17.5704 17.8166 GeneID:2002,Genbank:NM_005229.4,HGNC:HGNC:3321,MIM:311040 ELK1, ETS transcription factor GO:0000978,GO:0001077,GO:0001085,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0005739,GO:0009416,GO:0030154,GO:0030425,GO:0043025,GO:0043679,GO:0045893,GO:0045944,GO:0071394,GO:0071480,GO:0071774,GO:1901216 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|chromatin binding|DNA binding transcription factor activity|nucleus|nucleoplasm|mitochondrion|response to light stimulus|cell differentiation|dendrite|neuronal cell body|axon terminus|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|cellular response to testosterone stimulus|cellular response to gamma radiation|response to fibroblast growth factor|positive regulation of neuron death hsa04010,hsa04012,hsa04014,hsa04510,hsa04910,hsa04912,hsa04921,hsa05020,hsa05140,hsa05161,hsa05163,hsa05166,hsa05200,hsa05205,hsa05213,hsa05225 MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Focal adhesion|Insulin signaling pathway|GnRH signaling pathway|Oxytocin signaling pathway|Prion diseases|Leishmaniasis|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Endometrial cancer|Hepatocellular carcinoma ELK3 1302.99509344825 1347.23869388921 1258.75149300729 0.93431958176136 -0.0980119901759619 0.625115138395732 1 10.4791 10.7243 11.6093 8.20801 GeneID:2004,Genbank:NM_005230.3,HGNC:HGNC:3325,MIM:600247 ELK3, ETS transcription factor GO:0000978,GO:0001077,GO:0001525,GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0005739,GO:0007165,GO:0030154,GO:0032422,GO:0042060,GO:0045892,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|angiogenesis|DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|mitochondrion|signal transduction|cell differentiation|purine-rich negative regulatory element binding|wound healing|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter ELK4 267.224776312703 262.028210562897 272.421342062509 1.03966417004217 0.0561175875419432 0.89207879340852 1 1.26331 0.748588 1.36159 0.775977 GeneID:2005,Genbank:NM_001973.3,HGNC:HGNC:3326,MIM:600246 ELK4, ETS transcription factor GO:0000122,GO:0000978,GO:0000981,GO:0001047,GO:0001077,GO:0003677,GO:0003682,GO:0003700,GO:0003712,GO:0005634,GO:0005654,GO:0005829,GO:0030154,GO:0045944,GO:0070932 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|core promoter binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|chromatin binding|DNA binding transcription factor activity|transcription cofactor activity|nucleus|nucleoplasm|cytosol|cell differentiation|positive regulation of transcription from RNA polymerase II promoter|histone H3 deacetylation hsa04010,hsa05166,hsa05202 MAPK signaling pathway|Human T-cell leukemia virus 1 infection|Transcriptional misregulation in cancer ELL 419.807023097616 408.270385099184 431.343661096048 1.05651469427854 0.079312832786682 0.683934089455494 1 3.14336 3.27879 3.76123 3.08422 GeneID:8178,Genbank:NM_006532.3,HGNC:HGNC:23114,MIM:600284 elongation factor for RNA polymerase II ELL2 1389.45559705323 1582.76483112684 1196.14636297962 0.755732209521004 -0.404052982712079 0.00623585862718403 0.315120450994091 7.61279 7.05434 6.21999 4.97653 GeneID:22936,Genbank:NM_012081.5,HGNC:HGNC:17064,MIM:601874 elongation factor for RNA polymerase II 2 GO:0005654,GO:0006355,GO:0006368,GO:0008023,GO:0042795 nucleoplasm|regulation of transcription, DNA-templated|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|snRNA transcription from RNA polymerase II promoter ELL3 47.2410674557315 50.870356253341 43.611778658122 0.857312231920093 -0.222107367323049 0.613986632185031 1 0.705728 0.667558 0.65258 0.687757 GeneID:80237,Genbank:NM_025165.2,HGNC:HGNC:23113,MIM:609885 elongation factor for RNA polymerase II 3 GO:0005634,GO:0005654,GO:0005730,GO:0006354,GO:0006366,GO:0006368,GO:0007283,GO:0008023,GO:0010717,GO:0032786,GO:0035326,GO:0042795,GO:0045944,GO:0048863,GO:0050769,GO:1902166,GO:2000179 nucleus|nucleoplasm|nucleolus|DNA-templated transcription, elongation|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|spermatogenesis|transcription elongation factor complex|regulation of epithelial to mesenchymal transition|positive regulation of DNA-templated transcription, elongation|enhancer binding|snRNA transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|stem cell differentiation|positive regulation of neurogenesis|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of neural precursor cell proliferation ELMO1 13.2995372671367 14.0003482478079 12.5987262864655 0.899886635922656 -0.152184826882202 0.912048654325558 1 0.0625056 0.0413034 0.0296756 0.0473564 GeneID:9844,Genbank:NM_001206480.2,HGNC:HGNC:16286,MIM:606420 engulfment and cell motility 1 GO:0005085,GO:0005737,GO:0005886,GO:0006909,GO:0006911,GO:0006915,GO:0016477,GO:0016601,GO:0017124,GO:0030029,GO:0030036,GO:0032045,GO:0048870 guanyl-nucleotide exchange factor activity|cytoplasm|plasma membrane|phagocytosis|phagocytosis, engulfment|apoptotic process|cell migration|Rac protein signal transduction|SH3 domain binding|actin filament-based process|actin cytoskeleton organization|guanyl-nucleotide exchange factor complex|cell motility hsa04062,hsa05100,hsa05131 Chemokine signaling pathway|Bacterial invasion of epithelial cells|Shigellosis ELMO2 950.295840441436 954.583967068618 946.007713814254 0.991015716217506 -0.0130201580313324 0.931749112422561 1 6.34541 6.36716 6.58775 6.19469 GeneID:63916,Genbank:NM_182764.2,HGNC:HGNC:17233,MIM:606421 engulfment and cell motility 2 GO:0005829,GO:0006915,GO:0007010,GO:0016020,GO:0017124,GO:0030971,GO:0038096,GO:0048010,GO:0060326,GO:0098609 cytosol|apoptotic process|cytoskeleton organization|membrane|SH3 domain binding|receptor tyrosine kinase binding|Fc-gamma receptor signaling pathway involved in phagocytosis|vascular endothelial growth factor receptor signaling pathway|cell chemotaxis|cell-cell adhesion hsa05100,hsa05131 Bacterial invasion of epithelial cells|Shigellosis ELMO3 34.4432153459443 34.9577486723887 33.9286820195 0.970562559318888 -0.0431068875019346 0.967188864685167 1 0.559736 0.336027 0.47647 0.28439 GeneID:79767,Genbank:NM_024712.3,HGNC:HGNC:17289,MIM:606422 engulfment and cell motility 3 GO:0005737,GO:0006909,GO:0006915,GO:0016477,GO:0017124 cytoplasm|phagocytosis|apoptotic process|cell migration|SH3 domain binding hsa05100,hsa05131 Bacterial invasion of epithelial cells|Shigellosis ELMOD1 85.1519816577152 76.7666883170725 93.5372749983579 1.21846177097047 0.285060987461317 0.366690295178147 1 1.12026 0.794969 1.2331 1.07586 GeneID:55531,Genbank:XM_017017994.2,HGNC:HGNC:25334,MIM:615456 ELMO domain containing 1 GO:0005096 GTPase activator activity ELMOD2 242.1199570778 275.365999620224 208.873914535376 0.758531971352486 -0.398718105002254 0.22830326288733 1 1.15753 0.852179 0.770448 0.741809 GeneID:255520,Genbank:XM_005262885.3,HGNC:HGNC:28111,MIM:610196 ELMO domain containing 2 GO:0005096,GO:0016020,GO:0050688,GO:0051607 GTPase activator activity|membrane|regulation of defense response to virus|defense response to virus ELMOD3 287.916584403807 274.886753874229 300.946414933385 1.09480144347399 0.130669241981557 0.533139278670895 1 2.32695 2.35701 2.48113 2.58766 GeneID:84173,Genbank:XM_024453170.1,HGNC:HGNC:26158,MIM:615427 ELMO domain containing 3 GO:0005737,GO:0005856,GO:0032420,GO:0060091 cytoplasm|cytoskeleton|stereocilium|kinocilium ELMSAN1 606.535907943576 630.538219521199 582.533596365954 0.923867226967308 -0.114242564414307 0.474766378321284 1 2.75901 3.20794 2.90712 2.70802 GeneID:91748,Genbank:XM_005268206.1,HGNC:HGNC:19853 ELM2 and Myb/SANT domain containing 1 GO:0000118,GO:0003700,GO:0005654,GO:0005667,GO:0006351,GO:0006357,GO:0008134,GO:0044212 histone deacetylase complex|DNA binding transcription factor activity|nucleoplasm|transcription factor complex|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription factor binding|transcription regulatory region DNA binding ELN 2.07491320914491 3.18055978516888 0.969266633120943 0.304747182442752 -1.71431521249851 0.548518743267145 1 0.0626328 0.0135117 0 0 GeneID:2006,Genbank:XM_011515870.1,HGNC:HGNC:3327,MIM:130160 elastin hsa04974 Protein digestion and absorption ELOA 2442.98015383677 2196.65043163659 2689.30987603694 1.22427758067691 0.291930697625278 0.0337498505024122 0.726529039847626 14.1325 13.7071 18.3225 15.9952 GeneID:6924,Genbank:NM_003198.2,HGNC:HGNC:11620,MIM:600786 elongin A GO:0005615,GO:0005654,GO:0006357,GO:0006366,GO:0006368,GO:0070449 extracellular space|nucleoplasm|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|elongin complex ELOB 2219.51945894852 2290.46884282197 2148.57007507508 0.938048156301458 -0.0922661070358726 0.700196626527572 1 71.6344 82.589 64.5747 82.486 GeneID:6923,Genbank:NM_207013.2,HGNC:HGNC:11619,MIM:600787 elongin B GO:0005654,GO:0005829,GO:0006366,GO:0006368,GO:0006461,GO:0016567,GO:0030891,GO:0031462,GO:0031466,GO:0031625,GO:0043687,GO:0061418,GO:0070062,GO:0070449 nucleoplasm|cytosol|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|protein complex assembly|protein ubiquitination|VCB complex|Cul2-RING ubiquitin ligase complex|Cul5-RING ubiquitin ligase complex|ubiquitin protein ligase binding|post-translational protein modification|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|elongin complex hsa04066,hsa04120,hsa05170,hsa05200,hsa05211 HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection|Pathways in cancer|Renal cell carcinoma ELOC 1859.75746105823 2035.56508722009 1683.94983489637 0.827264058255239 -0.273580191452861 0.0534414732356072 0.844101218285488 28.6789 29.2524 23.5768 25.4538 GeneID:6921,Genbank:NM_001204864.1,HGNC:HGNC:11617,MIM:600788 elongin C GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0006368,GO:0016032,GO:0016567,GO:0032968,GO:0042787,GO:0043687,GO:0061418,GO:0070449 nucleoplasm|cytosol|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral process|protein ubiquitination|positive regulation of transcription elongation from RNA polymerase II promoter|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|post-translational protein modification|regulation of transcription from RNA polymerase II promoter in response to hypoxia|elongin complex hsa04066,hsa04120,hsa05170,hsa05200,hsa05211 HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection|Pathways in cancer|Renal cell carcinoma ELOF1 1450.48571524009 1454.43885240318 1446.532578077 0.99456403800468 -0.00786382856700771 0.943797137498297 1 31.4165 32.7028 32.2058 33.5579 GeneID:84337,Genbank:NM_032377.3,HGNC:HGNC:28691 elongation factor 1 homolog GO:0000993,GO:0006368,GO:0008023,GO:0046872,GO:0048096 RNA polymerase II core binding|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|metal ion binding|chromatin-mediated maintenance of transcription ELOVL1 3376.26667251803 3231.67273521026 3520.8606098258 1.08948550744781 0.123647005566036 0.361311720609335 1 72.8728 71.3292 83.1921 76.8628 GeneID:64834,Genbank:NM_001256402.1,HGNC:HGNC:14418,MIM:611813 ELOVL fatty acid elongase 1 GO:0005783,GO:0005789,GO:0009922,GO:0016020,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0036109,GO:0042761,GO:0043651,GO:0102336,GO:0102337,GO:0102338,GO:0102756 endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid elongase activity|membrane|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|very long-chain fatty acid biosynthetic process|linoleic acid metabolic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL2 382.527683432355 410.277679980844 354.777686883867 0.864725780111733 -0.209685393808129 0.274276184042367 1 2.63146 2.52034 2.45863 1.84609 GeneID:54898,Genbank:NM_017770.3,HGNC:HGNC:14416,MIM:611814 ELOVL fatty acid elongase 2 GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0036109,GO:0042761,GO:0043651,GO:0102336,GO:0102337,GO:0102338,GO:0102756 endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|very long-chain fatty acid biosynthetic process|linoleic acid metabolic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL3 3.44026525851173 4.4586688923012 2.42186162472226 0.543180416223348 -0.880496629161077 0.664281697855726 1 0.0161345 0.118512 0.0152697 0.0426699 GeneID:83401,Genbank:XM_011540245.2,HGNC:HGNC:18047,MIM:611815 ELOVL fatty acid elongase 3 GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0036109,GO:0042761,GO:0043651,GO:0102336,GO:0102337,GO:0102338,GO:0102756 endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|very long-chain fatty acid biosynthetic process|linoleic acid metabolic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL4 365.485836697742 368.420714061475 362.550959334009 0.984067793955563 -0.0231703864016961 0.939819520575475 1 5.86391 5.76487 6.66982 4.74312 GeneID:6785,Genbank:NM_022726.3,HGNC:HGNC:14415,MIM:605512 ELOVL fatty acid elongase 4 hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL5 13130.3878273946 13237.0593030523 13023.7163517369 0.983882904319521 -0.0234414697800031 0.88031473856412 1 139.752 126.89 146.021 120.773 GeneID:60481,Genbank:NM_001242830.1,HGNC:HGNC:21308,MIM:611805 ELOVL fatty acid elongase 5 GO:0005783,GO:0005789,GO:0006636,GO:0009922,GO:0016020,GO:0019367,GO:0030148,GO:0030176,GO:0030425,GO:0034625,GO:0034626,GO:0035338,GO:0036109,GO:0042761,GO:0043025,GO:0043651,GO:0045723,GO:0097447,GO:0102336,GO:0102337,GO:0102338,GO:0102756 endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|fatty acid elongase activity|membrane|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|dendrite|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|alpha-linolenic acid metabolic process|very long-chain fatty acid biosynthetic process|neuronal cell body|linoleic acid metabolic process|positive regulation of fatty acid biosynthetic process|dendritic tree|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL6 1490.85011504796 1552.45785644549 1429.24237365043 0.920631995075752 -0.119303512921894 0.429078743060871 1 9.12705 8.34413 8.70699 7.41159 GeneID:79071,Genbank:XM_011532233.3,HGNC:HGNC:15829,MIM:611546 ELOVL fatty acid elongase 6 GO:0005783,GO:0005789,GO:0009922,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0042759,GO:0042761,GO:0045540,GO:0102336,GO:0102337,GO:0102338,GO:0102756 endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid elongase activity|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|long-chain fatty acid biosynthetic process|very long-chain fatty acid biosynthetic process|regulation of cholesterol biosynthetic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELOVL7 197.9623485315 225.803178439339 170.12151862366 0.753406217748889 -0.408500155206421 0.0772081307062837 0.94157495521624 1.68234 1.5658 1.35984 0.996572 GeneID:79993,Genbank:NM_001104558.1,HGNC:HGNC:26292,MIM:614451 ELOVL fatty acid elongase 7 GO:0005783,GO:0005789,GO:0009922,GO:0019367,GO:0030148,GO:0030176,GO:0034625,GO:0034626,GO:0035338,GO:0042761,GO:0102336,GO:0102337,GO:0102338,GO:0102756 endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid elongase activity|fatty acid elongation, saturated fatty acid|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|3-oxo-arachidoyl-CoA synthase activity|3-oxo-cerotoyl-CoA synthase activity|3-oxo-lignoceronyl-CoA synthase activity|very-long-chain 3-ketoacyl-CoA synthase activity hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids ELP1 806.393652897092 755.013304615805 857.774001178379 1.13610448443007 0.184095521671256 0.24789290888253 1 4.03443 4.24677 4.68496 4.70584 GeneID:8518,Genbank:NM_001330749.1,HGNC:HGNC:5959,MIM:603722 elongator complex protein 1 GO:0000123,GO:0002098,GO:0004871,GO:0005730,GO:0005737,GO:0005829,GO:0006357,GO:0006368,GO:0006461,GO:0006468,GO:0006955,GO:0008023,GO:0008607,GO:0030335,GO:0033588 histone acetyltransferase complex|tRNA wobble uridine modification|signal transducer activity|nucleolus|cytoplasm|cytosol|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|protein complex assembly|protein phosphorylation|immune response|transcription elongation factor complex|phosphorylase kinase regulator activity|positive regulation of cell migration|Elongator holoenzyme complex ELP2 417.144793551998 438.817491153957 395.472095950039 0.901222271040444 -0.150045128936527 0.404579745410444 1 2.75397 3.135 2.76526 2.48033 GeneID:55250,Genbank:NM_001242875.2,HGNC:HGNC:18248,MIM:616054 elongator acetyltransferase complex subunit 2 GO:0000123,GO:0002098,GO:0005737,GO:0005829,GO:0006357,GO:0006368,GO:0008023,GO:0019901,GO:0033588,GO:0046425 histone acetyltransferase complex|tRNA wobble uridine modification|cytoplasm|cytosol|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|protein kinase binding|Elongator holoenzyme complex|regulation of JAK-STAT cascade ELP3 1149.51013141747 1118.96554112987 1180.05472170507 1.05459433586624 0.0766881532625585 0.602472457199323 1 10.8571 10.6387 11.6336 11.545 GeneID:55140,Genbank:NM_001284222.1,HGNC:HGNC:20696,MIM:612722 elongator acetyltransferase complex subunit 3 GO:0000123,GO:0001764,GO:0005730,GO:0005737,GO:0006357,GO:0006368,GO:0007417,GO:0008023,GO:0008607,GO:0010484,GO:0010485,GO:0030335,GO:0033588,GO:0043966,GO:0043967,GO:0046872,GO:0051536 histone acetyltransferase complex|neuron migration|nucleolus|cytoplasm|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|central nervous system development|transcription elongation factor complex|phosphorylase kinase regulator activity|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|positive regulation of cell migration|Elongator holoenzyme complex|histone H3 acetylation|histone H4 acetylation|metal ion binding|iron-sulfur cluster binding ELP4 446.414854434068 436.779753306118 456.049955562018 1.04411880841554 0.0622858829419444 0.722812872076145 1 5.17847 4.98143 5.92915 5.14797 GeneID:26610,Genbank:NM_001288725.1,HGNC:HGNC:1171,MIM:606985 elongator acetyltransferase complex subunit 4 GO:0000123,GO:0002098,GO:0005654,GO:0005737,GO:0006357,GO:0006368,GO:0008023,GO:0008607,GO:0033588,GO:0043966,GO:0043967 histone acetyltransferase complex|tRNA wobble uridine modification|nucleoplasm|cytoplasm|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription elongation factor complex|phosphorylase kinase regulator activity|Elongator holoenzyme complex|histone H3 acetylation|histone H4 acetylation ELP5 1349.16473226787 1364.18048754962 1334.14897698612 0.977985676501325 -0.0321147591493538 0.81850186437576 1 21.4823 20.0424 20.4334 20.7435 GeneID:23587,Genbank:NM_203415.2,HGNC:HGNC:30617,MIM:615019 elongator acetyltransferase complex subunit 5 GO:0002098,GO:0005634,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0030335,GO:0033588 tRNA wobble uridine modification|nucleus|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of cell migration|Elongator holoenzyme complex ELP6 1273.82214534718 1263.91979790392 1283.72449279044 1.01566926550195 0.0224306907918976 0.897745451886443 1 7.43514 7.72334 7.60761 8.10831 GeneID:54859,Genbank:XM_005265241.4,HGNC:HGNC:25976,MIM:615020 elongator acetyltransferase complex subunit 6 GO:0002098,GO:0006351,GO:0006355,GO:0030335,GO:0033588 tRNA wobble uridine modification|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of cell migration|Elongator holoenzyme complex EMB 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0107464 0 GeneID:133418,Genbank:XM_011543146.2,HGNC:HGNC:30465,MIM:615669 embigin GO:0005886,GO:0005887,GO:0008028,GO:0030054,GO:0035879,GO:0045202 plasma membrane|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|cell junction|plasma membrane lactate transport|synapse EMC1 4123.16876894727 3991.60637115586 4254.73116673868 1.06591952490211 0.0920985212047376 0.495530238019598 1 21.9457 22.3862 25.8461 22.2621 GeneID:23065,Genbank:NM_001271429.1,HGNC:HGNC:28957,MIM:616846 ER membrane protein complex subunit 1 GO:0016021,GO:0034975,GO:0072546 integral component of membrane|protein folding in endoplasmic reticulum|ER membrane protein complex EMC10 4734.16625128813 4868.03597294581 4600.29652963045 0.94500052078429 -0.0816129704925875 0.579245588642053 1 55.436 60.2825 53.1043 58.1255 GeneID:284361,Genbank:NM_175063.5,HGNC:HGNC:27609,MIM:614545 ER membrane protein complex subunit 10 GO:0005576,GO:0016021,GO:0072546 extracellular region|integral component of membrane|ER membrane protein complex EMC2 232.815800631019 240.735643216377 224.895958045661 0.934202991467785 -0.0981920300009913 0.670807223773691 1 1.47035 1.45899 1.77966 1.24414 GeneID:9694,Genbank:NM_001329495.1,HGNC:HGNC:28963,MIM:607722 ER membrane protein complex subunit 2 GO:0005634,GO:0005737,GO:0005739,GO:0005783,GO:0034975,GO:0072546 nucleus|cytoplasm|mitochondrion|endoplasmic reticulum|protein folding in endoplasmic reticulum|ER membrane protein complex EMC3 2961.53136503801 2868.64382357117 3054.41890650485 1.06476059572373 0.0905290866123863 0.516726434612679 1 31.8753 34.0979 33.8694 37.8281 GeneID:55831,Genbank:NM_018447.3,HGNC:HGNC:23999 ER membrane protein complex subunit 3 GO:0016021,GO:0034975,GO:0072546 integral component of membrane|protein folding in endoplasmic reticulum|ER membrane protein complex EMC4 2734.58356633701 2833.45575218047 2635.71138049356 0.930210884170422 -0.104370274303675 0.436844495733123 1 95.0289 103.874 88.9701 99.2342 GeneID:51234,Genbank:NM_001351373.1,HGNC:HGNC:28032,MIM:616245 ER membrane protein complex subunit 4 GO:0006915,GO:0016021,GO:0072546 apoptotic process|integral component of membrane|ER membrane protein complex EMC6 938.478939702659 780.785175165697 1096.17270423962 1.40393636957438 0.489477550044347 0.00161534695712681 0.142150532227159 53.0686 53.6934 70.7474 76.6971 GeneID:83460,Genbank:NM_001014764.2,HGNC:HGNC:28430 ER membrane protein complex subunit 6 GO:0000045,GO:0016021,GO:0030176,GO:0034975,GO:0072546,GO:0097631 autophagosome assembly|integral component of membrane|integral component of endoplasmic reticulum membrane|protein folding in endoplasmic reticulum|ER membrane protein complex|integral component of omegasome membrane EMC7 3045.21932099581 2979.2832735531 3111.15536843853 1.0442630266333 0.0624851404765704 0.661636902091453 1 111.298 123.041 121.063 127.767 GeneID:56851,Genbank:NM_020154.2,HGNC:HGNC:24301 ER membrane protein complex subunit 7 GO:0016021,GO:0030246,GO:0072546 integral component of membrane|carbohydrate binding|ER membrane protein complex EMC8 1037.97986269154 1083.47071178169 992.489013601389 0.916027542608243 -0.126537117758434 0.398488584134131 1 16.6706 17.7282 16.3303 16.9969 GeneID:10328,Genbank:NM_001142288.1,HGNC:HGNC:7864,MIM:604886 ER membrane protein complex subunit 8 GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0016020,GO:0072546 nucleus|cytoplasm|mitochondrion|cytosol|membrane|ER membrane protein complex EMC9 476.0879028846 430.746026004322 521.429779764878 1.21052719766623 0.275635493626319 0.123903364111365 1 5.45184 6.5226 7.48215 7.87874 GeneID:51016,Genbank:XM_024449620.1,HGNC:HGNC:20273 ER membrane protein complex subunit 9 GO:0005737,GO:0072546 cytoplasm|ER membrane protein complex EMD 2382.79767657471 2401.19250269644 2364.40285045298 0.984678591074166 -0.0222752035493288 0.852648077780896 1 55.7213 62.4742 59.1989 62.0452 GeneID:2010,Genbank:XM_024452349.1,HGNC:HGNC:3331,MIM:300384 emerin hsa05410,hsa05412,hsa05414 Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) EME1 527.276717271399 535.051748379522 519.501686163277 0.970937274266759 -0.0425499990650657 0.817132508879807 1 5.50052 5.31549 5.38311 5.17001 GeneID:146956,Genbank:NM_001166131.1,HGNC:HGNC:24965,MIM:610885 essential meiotic structure-specific endonuclease 1 GO:0000712,GO:0000790,GO:0003677,GO:0004520,GO:0005654,GO:0005720,GO:0005730,GO:0006302,GO:0031297,GO:0031573,GO:0036297,GO:0046872,GO:0048476,GO:0072429 resolution of meiotic recombination intermediates|nuclear chromatin|DNA binding|endodeoxyribonuclease activity|nucleoplasm|nuclear heterochromatin|nucleolus|double-strand break repair|replication fork processing|intra-S DNA damage checkpoint|interstrand cross-link repair|metal ion binding|Holliday junction resolvase complex|response to intra-S DNA damage checkpoint signaling hsa03440,hsa03460 Homologous recombination|Fanconi anemia pathway EME2 73.3101508480251 63.256411471222 83.3638902248283 1.3178725805961 0.398210889140682 0.241200973455782 1 1.2776 1.41018 2.1968 1.83066 GeneID:197342,Genbank:XM_017023026.1,HGNC:HGNC:27289,MIM:610886 essential meiotic structure-specific endonuclease subunit 2 GO:0000712,GO:0000790,GO:0003677,GO:0004519,GO:0006302,GO:0031297,GO:0031573,GO:0048476 resolution of meiotic recombination intermediates|nuclear chromatin|DNA binding|endonuclease activity|double-strand break repair|replication fork processing|intra-S DNA damage checkpoint|Holliday junction resolvase complex hsa03460 Fanconi anemia pathway EMG1 761.528219265483 796.189111035331 726.867327495634 0.912933017321032 -0.131419082568121 0.522077439378616 1 26.4982 30.0779 24.2538 29.3692 GeneID:10436,Genbank:NM_006331.7,HGNC:HGNC:16912,MIM:611531 EMG1, N1-specific pseudouridine methyltransferase GO:0000462,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0019843,GO:0032040,GO:0042274,GO:0070037,GO:0070475 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|rRNA binding|small-subunit processome|ribosomal small subunit biogenesis|rRNA (pseudouridine) methyltransferase activity|rRNA base methylation hsa03008 Ribosome biogenesis in eukaryotes EMID1 3.46014526853741 3.52655236307142 3.3937381740034 0.962338801357723 -0.0553831957077819 1 1 0.00737139 0.0258525 0.0206069 0 GeneID:129080,Genbank:NM_133455.3,HGNC:HGNC:18036,MIM:608926 EMI domain containing 1 GO:0005578,GO:0005581,GO:0005783,GO:0005794 proteinaceous extracellular matrix|collagen trimer|endoplasmic reticulum|Golgi apparatus EMILIN1 11.8507358771057 9.64754055998448 14.053931194227 1.45673719709654 0.542740631250536 0.554878505357541 1 0.104489 0.113601 0.164243 0.179362 GeneID:11117,Genbank:NM_007046.3,HGNC:HGNC:19880,MIM:130660 elastin microfibril interfacer 1 GO:0005576,GO:0005578,GO:0005581,GO:0005615,GO:0007155,GO:0007160,GO:0016477,GO:0030023,GO:0031012,GO:0034668,GO:0042802,GO:0070062,GO:0070207,GO:0098640,GO:1990971 extracellular region|proteinaceous extracellular matrix|collagen trimer|extracellular space|cell adhesion|cell-matrix adhesion|cell migration|extracellular matrix constituent conferring elasticity|extracellular matrix|integrin alpha4-beta1 complex|identical protein binding|extracellular exosome|protein homotrimerization|integrin binding involved in cell-matrix adhesion|EMILIN complex EMILIN2 17.8356467296874 13.856269423753 21.8150240356217 1.57437932018162 0.654783175797818 0.343128456459161 1 0.106097 0.103744 0.208472 0.116549 GeneID:84034,Genbank:NM_032048.2,HGNC:HGNC:19881,MIM:608928 elastin microfibril interfacer 2 GO:0005576,GO:0005578,GO:0005581,GO:0005615,GO:0007155,GO:0030023,GO:0031012 extracellular region|proteinaceous extracellular matrix|collagen trimer|extracellular space|cell adhesion|extracellular matrix constituent conferring elasticity|extracellular matrix EML1 819.574124136721 790.075897491816 849.072350781626 1.07467188086246 0.103896242967456 0.499460593648122 1 5.19692 4.72329 5.54074 5.37308 GeneID:2009,Genbank:XM_005267400.4,HGNC:HGNC:3330,MIM:602033 echinoderm microtubule associated protein like 1 GO:0000226,GO:0002244,GO:0005509,GO:0005829,GO:0005874,GO:0005875,GO:0007052,GO:0007405,GO:0007420,GO:0008017,GO:0015631,GO:0048471,GO:0097431,GO:1990023 microtubule cytoskeleton organization|hematopoietic progenitor cell differentiation|calcium ion binding|cytosol|microtubule|microtubule associated complex|mitotic spindle organization|neuroblast proliferation|brain development|microtubule binding|tubulin binding|perinuclear region of cytoplasm|mitotic spindle pole|mitotic spindle midzone EML2 138.778310897046 138.956713090118 138.599908703974 0.997432262334013 -0.00370922659806449 1 1 1.04038 1.00212 0.965643 1.03151 GeneID:24139,Genbank:XM_011526694.2,HGNC:HGNC:18035,MIM:617494 echinoderm microtubule associated protein like 2 GO:0005102,GO:0005737,GO:0005819,GO:0005874,GO:0005875,GO:0007601,GO:0007605,GO:0008017,GO:0008022,GO:0010968,GO:0015631,GO:0031115 receptor binding|cytoplasm|spindle|microtubule|microtubule associated complex|visual perception|sensory perception of sound|microtubule binding|protein C-terminus binding|regulation of microtubule nucleation|tubulin binding|negative regulation of microtubule polymerization EML3 785.981086567995 756.378674618054 815.583498517936 1.0782740522527 0.108723897550436 0.51744713062152 1 7.09508 7.74946 8.18901 8.78122 GeneID:256364,Genbank:XM_005273878.4,HGNC:HGNC:26666 echinoderm microtubule associated protein like 3 GO:0005737,GO:0005874,GO:0008017,GO:0015630 cytoplasm|microtubule|microtubule binding|microtubule cytoskeleton EML4 586.959187670368 595.184417994513 578.733957346222 0.97236073366349 -0.0404364599460206 0.902791562231573 1 3.65319 3.06999 3.73238 2.56342 GeneID:27436,Genbank:NM_019063.4,HGNC:HGNC:1316,MIM:607442 echinoderm microtubule associated protein like 4 hsa05200,hsa05223 Pathways in cancer|Non-small cell lung cancer EML5 51.5359639427995 61.8724411596118 41.1994867259872 0.665877827896029 -0.586670592150814 0.301545640035248 1 0.222366 0.112548 0.141251 0.0786138 GeneID:161436,Genbank:XM_017021065.2,HGNC:HGNC:18197 echinoderm microtubule associated protein like 5 GO:0003824,GO:0005737,GO:0005874,GO:0008017,GO:0015630,GO:0070062 catalytic activity|cytoplasm|microtubule|microtubule binding|microtubule cytoskeleton|extracellular exosome EML6 354.202377562881 399.284386728826 309.120368396935 0.774185965370277 -0.369247940543407 0.397882762706402 1 1.45963 1.06527 0.741754 1.22219 GeneID:400954,Genbank:XM_017004102.1,HGNC:HGNC:35412 echinoderm microtubule associated protein like 6 GO:0005737,GO:0005874,GO:0008017,GO:0015630 cytoplasm|microtubule|microtubule binding|microtubule cytoskeleton EMP1 1869.25321434171 1686.06301873451 2052.4434099489 1.21729934595766 0.283683984669831 0.0430426102717447 0.775444821273637 23.0735 22.1996 29.4002 26.573 GeneID:2012,Genbank:NM_001423.2,HGNC:HGNC:3333,MIM:602333 epithelial membrane protein 1 GO:0005886,GO:0007275,GO:0008219,GO:0008283,GO:0008544,GO:0016020,GO:0016021,GO:0016049,GO:0032060 plasma membrane|multicellular organism development|cell death|cell proliferation|epidermis development|membrane|integral component of membrane|cell growth|bleb assembly EMP2 660.542329929798 645.066856790541 676.017803069054 1.04798098980392 0.0676125468712017 0.701949534882567 1 4.31256 4.88212 4.62777 5.15196 GeneID:2013,Genbank:NM_001424.5,HGNC:HGNC:3334,MIM:602334 epithelial membrane protein 2 GO:0000139,GO:0001765,GO:0001913,GO:0001954,GO:0003093,GO:0005178,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0007015,GO:0007155,GO:0007160,GO:0007566,GO:0008219,GO:0008283,GO:0008284,GO:0009986,GO:0010594,GO:0016021,GO:0016324,GO:0016477,GO:0019900,GO:0019901,GO:0031410,GO:0032060,GO:0032147,GO:0034394,GO:0043534,GO:0043549,GO:0045022,GO:0045121,GO:0045177,GO:0045765,GO:0070252,GO:0072659,GO:2001046,GO:2001212 Golgi membrane|membrane raft assembly|T cell mediated cytotoxicity|positive regulation of cell-matrix adhesion|regulation of glomerular filtration|integrin binding|nucleus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|actin filament organization|cell adhesion|cell-matrix adhesion|embryo implantation|cell death|cell proliferation|positive regulation of cell proliferation|cell surface|regulation of endothelial cell migration|integral component of membrane|apical plasma membrane|cell migration|kinase binding|protein kinase binding|cytoplasmic vesicle|bleb assembly|activation of protein kinase activity|protein localization to cell surface|blood vessel endothelial cell migration|regulation of kinase activity|early endosome to late endosome transport|membrane raft|apical part of cell|regulation of angiogenesis|actin-mediated cell contraction|protein localization to plasma membrane|positive regulation of integrin-mediated signaling pathway|regulation of vasculogenesis EMP3 4879.30135301956 4841.79059730161 4916.81210873751 1.01549457993448 0.022182539464182 0.884668637546187 1 163.964 173.645 177.922 180.894 GeneID:2014,Genbank:NM_001425.2,HGNC:HGNC:3335,MIM:602335 epithelial membrane protein 3 GO:0005886,GO:0008219,GO:0008285,GO:0016021,GO:0016049,GO:0032060 plasma membrane|cell death|negative regulation of cell proliferation|integral component of membrane|cell growth|bleb assembly EMSY 216.518466832601 220.278122848861 212.758810816341 0.965864462910464 -0.0501073410292018 0.836319231198202 1 0.900376 0.807422 0.904221 0.844001 GeneID:56946,Genbank:XM_011545173.3,HGNC:HGNC:18071,MIM:608574 EMSY, BRCA2 interacting transcriptional repressor EMX1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00358036 GeneID:2016,Genbank:XM_011532697.3,HGNC:HGNC:3340,MIM:600034 empty spiracles homeobox 1 GO:0001701,GO:0005634,GO:0005730,GO:0005737,GO:0006355,GO:0009791,GO:0021796,GO:0021895,GO:0042493,GO:0043565,GO:0048854,GO:0048872,GO:0060019,GO:0060563,GO:0070445,GO:1990138 in utero embryonic development|nucleus|nucleolus|cytoplasm|regulation of transcription, DNA-templated|post-embryonic development|cerebral cortex regionalization|cerebral cortex neuron differentiation|response to drug|sequence-specific DNA binding|brain morphogenesis|homeostasis of number of cells|radial glial cell differentiation|neuroepithelial cell differentiation|regulation of oligodendrocyte progenitor proliferation|neuron projection extension EMX2 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0.0126013 0.0235083 GeneID:2018,Genbank:NM_004098.3,HGNC:HGNC:3341,MIM:600035 empty spiracles homeobox 2 GO:0005634,GO:0006355,GO:0009952,GO:0021542,GO:0021796,GO:0021846,GO:0021885,GO:0030182,GO:0042493,GO:0043565,GO:0072001 nucleus|regulation of transcription, DNA-templated|anterior/posterior pattern specification|dentate gyrus development|cerebral cortex regionalization|cell proliferation in forebrain|forebrain cell migration|neuron differentiation|response to drug|sequence-specific DNA binding|renal system development EN1 60.6611879496927 54.9350062930547 66.3873696063307 1.20847113864305 0.273183018296909 0.468675913241327 1 1.15957 1.04139 1.21041 1.45795 GeneID:2019,Genbank:NM_001426.3,HGNC:HGNC:3342,MIM:131290 engrailed homeobox 1 GO:0000122,GO:0000978,GO:0001078,GO:0001501,GO:0005634,GO:0008344,GO:0009653,GO:0009953,GO:0009954,GO:0021549,GO:0030901,GO:0030917,GO:0035115,GO:0035176,GO:0035264,GO:0042756,GO:0043473,GO:0043524,GO:0045944,GO:0048666,GO:0061743,GO:0071542,GO:1990403 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|skeletal system development|nucleus|adult locomotory behavior|anatomical structure morphogenesis|dorsal/ventral pattern formation|proximal/distal pattern formation|cerebellum development|midbrain development|midbrain-hindbrain boundary development|embryonic forelimb morphogenesis|social behavior|multicellular organism growth|drinking behavior|pigmentation|negative regulation of neuron apoptotic process|positive regulation of transcription from RNA polymerase II promoter|neuron development|motor learning|dopaminergic neuron differentiation|embryonic brain development EN2 13.630860072675 17.0848554836069 10.1768646617432 0.595665832321967 -0.747424887112547 0.35814262339911 1 0.318968 0.223239 0.166922 0.140206 GeneID:2020,Genbank:NM_001427.3,HGNC:HGNC:3343,MIM:131310 engrailed homeobox 2 GO:0001650,GO:0005634,GO:0005730,GO:0007275,GO:0016020,GO:0030901,GO:0030902,GO:0043524,GO:0043565,GO:0045944,GO:0048666,GO:1990403 fibrillar center|nucleus|nucleolus|multicellular organism development|membrane|midbrain development|hindbrain development|negative regulation of neuron apoptotic process|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|neuron development|embryonic brain development ENAH 3453.47027345967 3406.46721922389 3500.47332769544 1.0275963637463 0.0392736902380308 0.851158053957921 1 8.64027 7.81316 10.2346 6.99201 GeneID:55740,Genbank:NM_018212.5,HGNC:HGNC:18271,MIM:609061 ENAH, actin regulator GO:0001725,GO:0001843,GO:0003779,GO:0005522,GO:0005829,GO:0005886,GO:0005925,GO:0006928,GO:0007015,GO:0007411,GO:0008154,GO:0015629,GO:0017124,GO:0030027,GO:0030036,GO:0030054,GO:0030175,GO:0045202,GO:0050699,GO:1990830 stress fiber|neural tube closure|actin binding|profilin binding|cytosol|plasma membrane|focal adhesion|movement of cell or subcellular component|actin filament organization|axon guidance|actin polymerization or depolymerization|actin cytoskeleton|SH3 domain binding|lamellipodium|actin cytoskeleton organization|cell junction|filopodium|synapse|WW domain binding|cellular response to leukemia inhibitory factor hsa04360,hsa04810 Axon guidance|Regulation of actin cytoskeleton ENAM 1.02816907859967 2.05633815719933 0 0 -Inf 0.409782672813165 1 0.00932498 0.00895222 0 0 GeneID:10117,Genbank:XM_006714056.4,HGNC:HGNC:3344,MIM:606585 enamelin GO:0005578,GO:0005788,GO:0022604,GO:0030345,GO:0031214,GO:0036305,GO:0043687,GO:0044267,GO:0070175,GO:0097186 proteinaceous extracellular matrix|endoplasmic reticulum lumen|regulation of cell morphogenesis|structural constituent of tooth enamel|biomineral tissue development|ameloblast differentiation|post-translational protein modification|cellular protein metabolic process|positive regulation of enamel mineralization|amelogenesis ENC1 3911.78416495295 3556.57213004605 4266.99619985985 1.19974965889546 0.262733402877073 0.0485023378361059 0.806708656465773 28.242 26.7262 37.2067 29.8061 GeneID:8507,Genbank:NM_001256576.1,HGNC:HGNC:3345,MIM:605173 ectodermal-neural cortex 1 ENDOD1 729.489181448223 655.924862872757 803.053500023689 1.22430715083211 0.291965542828483 0.0725789932216947 0.929707214174252 5.56616 6.23359 7.66824 6.84471 GeneID:23052,Genbank:NM_015036.2,HGNC:HGNC:29129 endonuclease domain containing 1 GO:0002576,GO:0003676,GO:0004519,GO:0005576,GO:0005829,GO:0016020,GO:0046872,GO:0070062 platelet degranulation|nucleic acid binding|endonuclease activity|extracellular region|cytosol|membrane|metal ion binding|extracellular exosome ENDOG 348.587070716771 325.49736144393 371.676779989612 1.14187340364551 0.191402711946956 0.315818450161103 1 10.0526 9.90021 11.2127 13.6728 GeneID:2021,Genbank:XM_011518347.2,HGNC:HGNC:3346,MIM:600440 endonuclease G GO:0001701,GO:0003676,GO:0004519,GO:0004536,GO:0005634,GO:0005739,GO:0005829,GO:0006309,GO:0006310,GO:0007568,GO:0009612,GO:0032355,GO:0034612,GO:0036475,GO:0043204,GO:0046677,GO:0046872,GO:0071277,GO:0071333,GO:0071456,GO:1901300,GO:1902512 in utero embryonic development|nucleic acid binding|endonuclease activity|deoxyribonuclease activity|nucleus|mitochondrion|cytosol|apoptotic DNA fragmentation|DNA recombination|aging|response to mechanical stimulus|response to estradiol|response to tumor necrosis factor|neuron death in response to oxidative stress|perikaryon|response to antibiotic|metal ion binding|cellular response to calcium ion|cellular response to glucose stimulus|cellular response to hypoxia|positive regulation of hydrogen peroxide-mediated programmed cell death|positive regulation of apoptotic DNA fragmentation hsa04210 Apoptosis ENDOU 1.0041559412572 2.00831188251439 0 0 -Inf 0.414392508436943 1 0.0155326 0.0432407 0 0 GeneID:8909,Genbank:NM_001172440.1,HGNC:HGNC:14369,MIM:606720 endonuclease, poly(U) specific GO:0003723,GO:0004521,GO:0005044,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0006508,GO:0006955,GO:0007565,GO:0008083,GO:0008236,GO:0030145,GO:0030247 RNA binding|endoribonuclease activity|scavenger receptor activity|extracellular region|extracellular space|cytoplasm|plasma membrane|proteolysis|immune response|female pregnancy|growth factor activity|serine-type peptidase activity|manganese ion binding|polysaccharide binding ENDOV 114.512611931822 103.018821613814 126.006402249829 1.22313961930363 0.29058909444599 0.308105966880148 1 0.385922 0.404679 0.619094 0.38282 GeneID:284131,Genbank:XM_011524658.2,HGNC:HGNC:26640 endonuclease V ENG 24.3877084227988 30.3550009560326 18.4204158895649 0.606832986638536 -0.720628584176587 0.216960044119985 1 0.361629 0.297826 0.252164 0.149487 GeneID:2022,Genbank:NM_001114753.2,HGNC:HGNC:3349,MIM:131195 endoglin ENGASE 345.761815605228 331.445861852319 360.077769358137 1.08638486944989 0.119535291799826 0.552190400704857 1 2.85321 3.10465 3.3047 3.15902 GeneID:64772,Genbank:XM_006722019.3,HGNC:HGNC:24622,MIM:611898 endo-beta-N-acetylglucosaminidase GO:0005764,GO:0005829,GO:0006457,GO:0006517,GO:0033925 lysosome|cytosol|protein folding|protein deglycosylation|mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity hsa00511 Other glycan degradation ENHO 119.697481068234 112.926110857439 126.468851279028 1.11992567811607 0.163402993558632 0.693937450705646 1 4.84571 6.94912 5.87993 7.73455 GeneID:375704,Genbank:NM_198573.2,HGNC:HGNC:24838 energy homeostasis associated GO:0005576,GO:0005886,GO:0045747 extracellular region|plasma membrane|positive regulation of Notch signaling pathway ENKD1 350.166725682074 358.706546917445 341.626904446703 0.95238547325797 -0.0703824795484556 0.71341892715449 1 5.96925 5.82922 5.11417 6.56453 GeneID:84080,Genbank:XM_024450469.1,HGNC:HGNC:25246 enkurin domain containing 1 GO:0005881,GO:0015630 cytoplasmic microtubule|microtubule cytoskeleton ENKUR 8.58803502088875 6.51500704950053 10.661062992277 1.63638548834637 0.710512648410732 0.525889487945084 1 0 0.0917798 0.0611422 0.0568796 GeneID:219670,Genbank:NM_001270383.1,HGNC:HGNC:28388,MIM:611025 enkurin, TRPC channel interacting protein GO:0001669,GO:0005516,GO:0017124,GO:0097228 acrosomal vesicle|calmodulin binding|SH3 domain binding|sperm principal piece ENO1 93743.9922420815 93958.9948641104 93528.9896200526 0.995423479735179 -0.00661767763534438 0.944694845810122 1 1021.28 1082.86 1017.15 1128.41 GeneID:2023,Genbank:NM_001428.4,HGNC:HGNC:3350,MIM:172430 enolase 1 hsa00010,hsa03018,hsa04066 Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway ENO2 2218.48459410154 2193.39445361312 2243.57473458995 1.02287791003308 0.0326339563234355 0.874300567787533 1 36.7246 36.8867 34.0071 41.9196 GeneID:2026,Genbank:NM_001975.2,HGNC:HGNC:3353,MIM:131360 enolase 2 GO:0000015,GO:0000287,GO:0001917,GO:0004634,GO:0005615,GO:0005829,GO:0005886,GO:0006094,GO:0006096,GO:0016020,GO:0043204,GO:0043209,GO:0061621,GO:0070062 phosphopyruvate hydratase complex|magnesium ion binding|photoreceptor inner segment|phosphopyruvate hydratase activity|extracellular space|cytosol|plasma membrane|gluconeogenesis|glycolytic process|membrane|perikaryon|myelin sheath|canonical glycolysis|extracellular exosome hsa00010,hsa03018,hsa04066 Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway ENO3 56.3913216570802 58.0195135288537 54.7631297853066 0.943874335624553 -0.0833332982655828 0.853038790919183 1 0.733596 0.453147 0.641287 0.403051 GeneID:2027,Genbank:XM_011523729.1,HGNC:HGNC:3354,MIM:131370 enolase 3 GO:0000015,GO:0000287,GO:0004634,GO:0005615,GO:0005829,GO:0005886,GO:0006094,GO:0007568,GO:0016020,GO:0042493,GO:0042803,GO:0043403,GO:0046982,GO:0061621,GO:0070062 phosphopyruvate hydratase complex|magnesium ion binding|phosphopyruvate hydratase activity|extracellular space|cytosol|plasma membrane|gluconeogenesis|aging|membrane|response to drug|protein homodimerization activity|skeletal muscle tissue regeneration|protein heterodimerization activity|canonical glycolysis|extracellular exosome hsa00010,hsa03018,hsa04066 Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway ENO4 36.0813176864583 44.0573829006229 28.1052524722938 0.637923785343509 -0.648544023679344 0.184157137504745 1 0.12378 0.0987419 0.0383422 0.0785121 GeneID:387712,Genbank:XM_006717835.3,HGNC:HGNC:31670,MIM:131375 enolase 4 GO:0000015,GO:0000287,GO:0004634,GO:0006096 phosphopyruvate hydratase complex|magnesium ion binding|phosphopyruvate hydratase activity|glycolytic process hsa00010,hsa03018,hsa04066 Glycolysis / Gluconeogenesis|RNA degradation|HIF-1 signaling pathway ENOPH1 1420.86984334936 1548.72059867432 1293.01908802441 0.834895002449902 -0.260333321216319 0.0772505432183174 0.94157495521624 30.7595 29.1757 26.4509 23.5754 GeneID:58478,Genbank:NM_021204.4,HGNC:HGNC:24599 enolase-phosphatase 1 GO:0000287,GO:0005634,GO:0005829,GO:0019509,GO:0043874,GO:0070062 magnesium ion binding|nucleus|cytosol|L-methionine salvage from methylthioadenosine|acireductone synthase activity|extracellular exosome hsa00270 Cysteine and methionine metabolism ENOSF1 5.83268856668944 8.27337890348227 3.3919982298966 0.409989469776237 -1.28634123905102 0.326373591483495 1 0.0523689 0.0383523 0.00994126 0.0184735 GeneID:55556,Genbank:NM_001354065.1,HGNC:HGNC:30365,MIM:607427 enolase superfamily member 1 GO:0000287,GO:0005739,GO:0009063,GO:0016853,GO:0044275,GO:0050023 magnesium ion binding|mitochondrion|cellular amino acid catabolic process|isomerase activity|cellular carbohydrate catabolic process|L-fuconate dehydratase activity hsa00051 Fructose and mannose metabolism ENOX1 78.5719784216229 82.503466316506 74.6404905267398 0.90469520687044 -0.144496266890353 0.671972962190095 1 0.170973 0.179384 0.182673 0.128833 GeneID:55068,Genbank:NM_001347965.1,HGNC:HGNC:25474,MIM:610914 ecto-NOX disulfide-thiol exchanger 1 GO:0003676,GO:0005615,GO:0005886,GO:0016491,GO:0048511 nucleic acid binding|extracellular space|plasma membrane|oxidoreductase activity|rhythmic process ENOX2 261.494007367375 269.024497360102 253.963517374648 0.944016325155348 -0.0831162861296812 0.72205041102137 1 1.80504 1.45324 1.69651 1.38911 GeneID:10495,Genbank:XM_011531245.2,HGNC:HGNC:2259,MIM:300282 ecto-NOX disulfide-thiol exchanger 2 GO:0003676,GO:0005615,GO:0005829,GO:0007624,GO:0009897,GO:0015035,GO:0016049,GO:0040008,GO:0055114 nucleic acid binding|extracellular space|cytosol|ultradian rhythm|external side of plasma membrane|protein disulfide oxidoreductase activity|cell growth|regulation of growth|oxidation-reduction process ENPEP 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.00779187 0 GeneID:2028,Genbank:NM_001977.3,HGNC:HGNC:3355,MIM:138297 glutamyl aminopeptidase GO:0001525,GO:0002003,GO:0002005,GO:0003081,GO:0004177,GO:0005765,GO:0005886,GO:0005887,GO:0005903,GO:0007267,GO:0008237,GO:0008270,GO:0008283,GO:0009897,GO:0016324,GO:0016477,GO:0031410,GO:0032835,GO:0042277,GO:0043171,GO:0045177,GO:0070006,GO:0070062 angiogenesis|angiotensin maturation|angiotensin catabolic process in blood|regulation of systemic arterial blood pressure by renin-angiotensin|aminopeptidase activity|lysosomal membrane|plasma membrane|integral component of plasma membrane|brush border|cell-cell signaling|metallopeptidase activity|zinc ion binding|cell proliferation|external side of plasma membrane|apical plasma membrane|cell migration|cytoplasmic vesicle|glomerulus development|peptide binding|peptide catabolic process|apical part of cell|metalloaminopeptidase activity|extracellular exosome hsa04614 Renin-angiotensin system ENPP1 208.795850033905 219.836077721589 197.755622346221 0.899559455371417 -0.152709456951681 0.50707459499875 1 1.20324 1.19509 1.29839 0.898895 GeneID:5167,Genbank:NM_006208.2,HGNC:HGNC:3356,MIM:173335 ectonucleotide pyrophosphatase/phosphodiesterase 1 GO:0003676,GO:0004527,GO:0004528,GO:0004551,GO:0005044,GO:0005158,GO:0005509,GO:0005524,GO:0005615,GO:0005765,GO:0005886,GO:0005887,GO:0006091,GO:0006771,GO:0006796,GO:0006955,GO:0008270,GO:0009143,GO:0009986,GO:0016021,GO:0016323,GO:0030247,GO:0030308,GO:0030500,GO:0030505,GO:0030643,GO:0030730,GO:0031214,GO:0031953,GO:0032869,GO:0035529,GO:0042803,GO:0045599,GO:0045719,GO:0046034,GO:0046325,GO:0046627,GO:0047429,GO:0050427,GO:0050656,GO:0090305 nucleic acid binding|exonuclease activity|phosphodiesterase I activity|nucleotide diphosphatase activity|scavenger receptor activity|insulin receptor binding|calcium ion binding|ATP binding|extracellular space|lysosomal membrane|plasma membrane|integral component of plasma membrane|generation of precursor metabolites and energy|riboflavin metabolic process|phosphate-containing compound metabolic process|immune response|zinc ion binding|nucleoside triphosphate catabolic process|cell surface|integral component of membrane|basolateral plasma membrane|polysaccharide binding|negative regulation of cell growth|regulation of bone mineralization|inorganic diphosphate transport|cellular phosphate ion homeostasis|sequestering of triglyceride|biomineral tissue development|negative regulation of protein autophosphorylation|cellular response to insulin stimulus|NADH pyrophosphatase activity|protein homodimerization activity|negative regulation of fat cell differentiation|negative regulation of glycogen biosynthetic process|ATP metabolic process|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|nucleoside-triphosphate diphosphatase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|3'-phosphoadenosine 5'-phosphosulfate binding|nucleic acid phosphodiester bond hydrolysis hsa00230,hsa00240,hsa00500,hsa00740,hsa00760,hsa00770 Purine metabolism|Pyrimidine metabolism|Starch and sucrose metabolism|Riboflavin metabolism|Nicotinate and nicotinamide metabolism|Pantothenate and CoA biosynthesis ENPP2 17.6392905424968 14.4423933750803 20.8361877099134 1.44271016366756 0.528781495644237 0.445367288535025 1 0.0834842 0.0785942 0.150046 0.204373 GeneID:5168,Genbank:NM_001040092.2,HGNC:HGNC:3357,MIM:601060 ectonucleotide pyrophosphatase/phosphodiesterase 2 hsa00565 Ether lipid metabolism ENPP3 1.02523254288787 1.56626675524197 0.484198330533773 0.309141676482158 -1.69365993276169 0.789571303159055 1 0.0209059 0.00993436 0 0.009334 GeneID:5169,Genbank:NM_005021.4,HGNC:HGNC:3358,MIM:602182 ectonucleotide pyrophosphatase/phosphodiesterase 3 GO:0003676,GO:0004528,GO:0004551,GO:0005044,GO:0005887,GO:0006796,GO:0006955,GO:0009143,GO:0030247,GO:0035529,GO:0046872,GO:0047429,GO:0048471,GO:0070062 nucleic acid binding|phosphodiesterase I activity|nucleotide diphosphatase activity|scavenger receptor activity|integral component of plasma membrane|phosphate-containing compound metabolic process|immune response|nucleoside triphosphate catabolic process|polysaccharide binding|NADH pyrophosphatase activity|metal ion binding|nucleoside-triphosphate diphosphatase activity|perinuclear region of cytoplasm|extracellular exosome hsa00230,hsa00240,hsa00500,hsa00740,hsa00760,hsa00770 Purine metabolism|Pyrimidine metabolism|Starch and sucrose metabolism|Riboflavin metabolism|Nicotinate and nicotinamide metabolism|Pantothenate and CoA biosynthesis ENPP4 241.030118263974 267.814031837871 214.246204690078 0.799981252736519 -0.321961903513568 0.237006701062093 1 2.75358 2.68548 2.77405 1.6638 GeneID:22875,Genbank:NM_014936.4,HGNC:HGNC:3359,MIM:617000 ectonucleotide pyrophosphatase/phosphodiesterase 4 GO:0005886,GO:0007596,GO:0016020,GO:0016021,GO:0030194,GO:0043312,GO:0046130,GO:0046872,GO:0047710,GO:0070062,GO:0101003 plasma membrane|blood coagulation|membrane|integral component of membrane|positive regulation of blood coagulation|neutrophil degranulation|purine ribonucleoside catabolic process|metal ion binding|bis(5'-adenosyl)-triphosphatase activity|extracellular exosome|ficolin-1-rich granule membrane hsa00230 Purine metabolism ENPP5 54.0443002811061 47.4976913694324 60.5909091927798 1.27566008885589 0.351243961195011 0.385719360607285 1 0.394017 0.471152 0.691473 0.428168 GeneID:59084,Genbank:NM_001290073.1,HGNC:HGNC:13717,MIM:617001 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) GO:0005576,GO:0005886,GO:0007154,GO:0008152,GO:0016021,GO:0016787,GO:0046872 extracellular region|plasma membrane|cell communication|metabolic process|integral component of membrane|hydrolase activity|metal ion binding ENPP6 384.556436700509 378.481890784263 390.630982616755 1.03209953270767 0.0455821068266548 0.814954161593225 1 3.30478 3.33388 3.92796 3.2614 GeneID:133121,Genbank:NM_153343.3,HGNC:HGNC:23409,MIM:616983 ectonucleotide pyrophosphatase/phosphodiesterase 6 GO:0005576,GO:0005886,GO:0006629,GO:0008081,GO:0008889,GO:0019695,GO:0031225,GO:0046475,GO:0047390,GO:0070062 extracellular region|plasma membrane|lipid metabolic process|phosphoric diester hydrolase activity|glycerophosphodiester phosphodiesterase activity|choline metabolic process|anchored component of membrane|glycerophospholipid catabolic process|glycerophosphocholine cholinephosphodiesterase activity|extracellular exosome hsa00565 Ether lipid metabolism ENSA 4849.9207450021 4194.32039277512 5505.52109722909 1.31261338707281 0.392442052037477 0.00364609231572794 0.23228198930871 24.4442 25.8795 31.7928 33.8456 GeneID:2029,Genbank:NM_004436.2,HGNC:HGNC:3360,MIM:603061 endosulfine alpha GO:0000086,GO:0000278,GO:0004864,GO:0005102,GO:0005654,GO:0005737,GO:0006810,GO:0007584,GO:0008200,GO:0009749,GO:0019212,GO:0019870,GO:0019888,GO:0035308,GO:0050796,GO:0051301,GO:0051721 G2/M transition of mitotic cell cycle|mitotic cell cycle|protein phosphatase inhibitor activity|receptor binding|nucleoplasm|cytoplasm|transport|response to nutrient|ion channel inhibitor activity|response to glucose|phosphatase inhibitor activity|potassium channel inhibitor activity|protein phosphatase regulator activity|negative regulation of protein dephosphorylation|regulation of insulin secretion|cell division|protein phosphatase 2A binding ENTPD1 58.9677531239939 75.2964741112004 42.6390321367875 0.566281922760643 -0.820407619025915 0.0308789626899727 0.695580121578908 0.180323 0.150008 0.0791949 0.101557 GeneID:953,Genbank:XM_011540371.2,HGNC:HGNC:3363,MIM:601752 ectonucleoside triphosphate diphosphohydrolase 1 GO:0005524,GO:0005886,GO:0005887,GO:0007155,GO:0007596,GO:0016020,GO:0017110,GO:0017111,GO:0034656,GO:0070062,GO:0102485,GO:0102486,GO:0102487,GO:0102488,GO:0102489,GO:0102490,GO:0102491 ATP binding|plasma membrane|integral component of plasma membrane|cell adhesion|blood coagulation|membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|nucleobase-containing small molecule catabolic process|extracellular exosome|dATP phosphohydrolase activity|dCTP phosphohydrolase activity|dUTP phosphohydrolase activity|dTTP phosphohydrolase activity|GTP phosphohydrolase activity|8-oxo-dGTP phosphohydrolase activity|dGTP phosphohydrolase activity hsa00230,hsa00240,hsa05169 Purine metabolism|Pyrimidine metabolism|Epstein-Barr virus infection ENTPD3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00832519 0 0 0 GeneID:956,Genbank:NM_001248.3,HGNC:HGNC:3365,MIM:603161 ectonucleoside triphosphate diphosphohydrolase 3 GO:0005524,GO:0005886,GO:0009134,GO:0009143,GO:0016021,GO:0017110,GO:0017111,GO:0034656,GO:0102485,GO:0102486,GO:0102487,GO:0102488,GO:0102489,GO:0102490,GO:0102491 ATP binding|plasma membrane|nucleoside diphosphate catabolic process|nucleoside triphosphate catabolic process|integral component of membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|nucleobase-containing small molecule catabolic process|dATP phosphohydrolase activity|dCTP phosphohydrolase activity|dUTP phosphohydrolase activity|dTTP phosphohydrolase activity|GTP phosphohydrolase activity|8-oxo-dGTP phosphohydrolase activity|dGTP phosphohydrolase activity hsa00230,hsa00240,hsa05169 Purine metabolism|Pyrimidine metabolism|Epstein-Barr virus infection ENTPD4 2087.88216405877 1816.36315972452 2359.40116839303 1.29896995309621 0.377368059715394 0.0190452016651226 0.565914563763644 11.2356 11.6064 17.4861 13.2511 GeneID:9583,Genbank:NM_001128930.2,HGNC:HGNC:14573,MIM:607577 ectonucleoside triphosphate diphosphohydrolase 4 GO:0000139,GO:0006256,GO:0017110,GO:0017111,GO:0030173,GO:0031410,GO:0034656,GO:0045134,GO:0097637 Golgi membrane|UDP catabolic process|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|integral component of Golgi membrane|cytoplasmic vesicle|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|integral component of autophagosome membrane hsa00230,hsa00240,hsa04142 Purine metabolism|Pyrimidine metabolism|Lysosome ENTPD5 395.88125450972 387.053235990963 404.709273028477 1.04561655967637 0.0643538947289565 0.737754057271173 1 1.57124 1.64936 1.89629 1.41724 GeneID:957,Genbank:NM_001330189.1,HGNC:HGNC:3367,MIM:603162 ectonucleoside triphosphate diphosphohydrolase 5 GO:0004382,GO:0005576,GO:0005783,GO:0006487,GO:0008283,GO:0014066,GO:0017110,GO:0034656,GO:0045134,GO:0045821,GO:0046034,GO:0051084,GO:0070062 guanosine-diphosphatase activity|extracellular region|endoplasmic reticulum|protein N-linked glycosylation|cell proliferation|regulation of phosphatidylinositol 3-kinase signaling|nucleoside-diphosphatase activity|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|positive regulation of glycolytic process|ATP metabolic process|'de novo' posttranslational protein folding|extracellular exosome hsa00230,hsa00240 Purine metabolism|Pyrimidine metabolism ENTPD6 1569.28271455063 1514.04323299664 1624.52219610462 1.07296949036873 0.101609053988634 0.486864596985318 1 8.10948 8.13411 9.54771 8.44892 GeneID:955,Genbank:NM_001322390.1,HGNC:HGNC:3368,MIM:603160 ectonucleoside triphosphate diphosphohydrolase 6 (putative) GO:0000139,GO:0005576,GO:0005794,GO:0005886,GO:0008894,GO:0009986,GO:0016021,GO:0017110,GO:0017111,GO:0032026,GO:0034656,GO:0045134,GO:0051592,GO:0070062 Golgi membrane|extracellular region|Golgi apparatus|plasma membrane|guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity|cell surface|integral component of membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|response to magnesium ion|nucleobase-containing small molecule catabolic process|uridine-diphosphatase activity|response to calcium ion|extracellular exosome hsa00230,hsa00240 Purine metabolism|Pyrimidine metabolism ENTPD7 576.368648950367 698.588466806662 454.148831094072 0.650094945268772 -0.621277658184284 0.000245488425958272 0.0409556523973718 3.12396 3.14721 2.3847 1.70722 GeneID:57089,Genbank:NM_001349962.1,HGNC:HGNC:19745,MIM:616753 ectonucleoside triphosphate diphosphohydrolase 7 GO:0016021,GO:0017111,GO:0030666,GO:0034656,GO:0046872 integral component of membrane|nucleoside-triphosphatase activity|endocytic vesicle membrane|nucleobase-containing small molecule catabolic process|metal ion binding ENTPD8 1.48672269415927 1.51824048055703 1.45520490776151 0.958481167112346 -0.0611780097655067 1 1 0.0227858 0 0.0208834 0 GeneID:377841,Genbank:XM_011518666.2,HGNC:HGNC:24860,MIM:616748 ectonucleoside triphosphate diphosphohydrolase 8 GO:0005524,GO:0005886,GO:0009124,GO:0009133,GO:0016021,GO:0017110,GO:0017111,GO:0034656,GO:0046872,GO:0102485,GO:0102486,GO:0102487,GO:0102488,GO:0102489,GO:0102490,GO:0102491 ATP binding|plasma membrane|nucleoside monophosphate biosynthetic process|nucleoside diphosphate biosynthetic process|integral component of membrane|nucleoside-diphosphatase activity|nucleoside-triphosphatase activity|nucleobase-containing small molecule catabolic process|metal ion binding|dATP phosphohydrolase activity|dCTP phosphohydrolase activity|dUTP phosphohydrolase activity|dTTP phosphohydrolase activity|GTP phosphohydrolase activity|8-oxo-dGTP phosphohydrolase activity|dGTP phosphohydrolase activity hsa00230,hsa00240,hsa05169 Purine metabolism|Pyrimidine metabolism|Epstein-Barr virus infection ENY2 1123.91468209133 1199.63318335239 1048.19618083027 0.873763909982112 -0.194684577071707 0.201867511097633 1 15.8589 15.3853 12.3067 13.9439 GeneID:56943,Genbank:NM_020189.5,HGNC:HGNC:24449 ENY2, transcription and export complex 2 subunit GO:0000124,GO:0003682,GO:0003713,GO:0005643,GO:0005654,GO:0005739,GO:0006351,GO:0006357,GO:0016578,GO:0016973,GO:0030374,GO:0045893,GO:0061179,GO:0071819 SAGA complex|chromatin binding|transcription coactivator activity|nuclear pore|nucleoplasm|mitochondrion|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|histone deubiquitination|poly(A)+ mRNA export from nucleus|ligand-dependent nuclear receptor transcription coactivator activity|positive regulation of transcription, DNA-templated|negative regulation of insulin secretion involved in cellular response to glucose stimulus|DUBm complex EOGT 224.711370129589 246.808605138605 202.614135120573 0.820936267626436 -0.284657870385213 0.323313759719326 1 1.74042 1.5287 1.66056 0.884186 GeneID:285203,Genbank:NM_173654.2,HGNC:HGNC:28526,MIM:614789 EGF domain specific O-linked N-acetylglucosamine transferase GO:0005788,GO:0006493,GO:0016262 endoplasmic reticulum lumen|protein O-linked glycosylation|protein N-acetylglucosaminyltransferase activity hsa00514 Other types of O-glycan biosynthesis EOMES 11.9963604131708 14.2983145510254 9.69440627531622 0.678010421488522 -0.560620646135981 0.517752247550493 1 0.131383 0.192396 0.136769 0.0926728 GeneID:8320,Genbank:NM_001278183.1,HGNC:HGNC:3372,MIM:604615 eomesodermin GO:0000122,GO:0000977,GO:0001102,GO:0001191,GO:0001706,GO:0001707,GO:0001714,GO:0001829,GO:0002250,GO:0002302,GO:0003677,GO:0003682,GO:0003700,GO:0005634,GO:0006351,GO:0007420,GO:0010002,GO:0019827,GO:0021772,GO:0021796,GO:0021895,GO:0032609,GO:0035914,GO:0043565,GO:0045597,GO:0045664,GO:0045893,GO:0045944,GO:0060706,GO:0060809 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|transcriptional repressor activity, RNA polymerase II transcription factor binding|endoderm formation|mesoderm formation|endodermal cell fate specification|trophectodermal cell differentiation|adaptive immune response|CD8-positive, alpha-beta T cell differentiation involved in immune response|DNA binding|chromatin binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|brain development|cardioblast differentiation|stem cell population maintenance|olfactory bulb development|cerebral cortex regionalization|cerebral cortex neuron differentiation|interferon-gamma production|skeletal muscle cell differentiation|sequence-specific DNA binding|positive regulation of cell differentiation|regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|cell differentiation involved in embryonic placenta development|mesodermal to mesenchymal transition involved in gastrulation EP300 1170.11832938774 1146.94763731613 1193.28902145936 1.04040409748057 0.0571439862498077 0.738795795081258 1 4.11366 4.16807 5.0216 3.68044 GeneID:2033,Genbank:XM_006724165.4,HGNC:HGNC:3373,MIM:602700 E1A binding protein p300 hsa04024,hsa04066,hsa04068,hsa04110,hsa04310,hsa04330,hsa04350,hsa04520,hsa04630,hsa04720,hsa04916,hsa04919,hsa04922,hsa05016,hsa05152,hsa05161,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05200,hsa05203,hsa05206,hsa05211,hsa05215 cAMP signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Cell cycle|Wnt signaling pathway|Notch signaling pathway|TGF-beta signaling pathway|Adherens junction|Jak-STAT signaling pathway|Long-term potentiation|Melanogenesis|Thyroid hormone signaling pathway|Glucagon signaling pathway|Huntington disease|Tuberculosis|Hepatitis B|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Pathways in cancer|Viral carcinogenesis|MicroRNAs in cancer|Renal cell carcinoma|Prostate cancer EP400 1580.97783396639 1591.6175763291 1570.33809160367 0.986630277874595 -0.0194185332094638 0.883195453370837 1 4.79786 4.97645 5.53765 4.33623 GeneID:57634,Genbank:NM_015409.4,HGNC:HGNC:11958,MIM:606265 E1A binding protein p400 EPAS1 1017.38405195931 885.206567400483 1149.56153651813 1.29863647520596 0.376997636470441 0.0136214396242694 0.479474674774284 6.07871 6.02828 8.26312 7.73466 GeneID:2034,Genbank:NM_001430.4,HGNC:HGNC:3374,MIM:603349 endothelial PAS domain protein 1 GO:0000981,GO:0001077,GO:0001525,GO:0001666,GO:0001892,GO:0001974,GO:0002027,GO:0003677,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006366,GO:0007005,GO:0007165,GO:0007601,GO:0008134,GO:0016567,GO:0016607,GO:0030218,GO:0030324,GO:0035019,GO:0035035,GO:0042415,GO:0043129,GO:0043619,GO:0043687,GO:0045944,GO:0046982,GO:0048469,GO:0048625,GO:0055072,GO:0061418,GO:0071456 RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|angiogenesis|response to hypoxia|embryonic placenta development|blood vessel remodeling|regulation of heart rate|DNA binding|nucleus|nucleoplasm|transcription factor complex|cytosol|transcription from RNA polymerase II promoter|mitochondrion organization|signal transduction|visual perception|transcription factor binding|protein ubiquitination|nuclear speck|erythrocyte differentiation|lung development|somatic stem cell population maintenance|histone acetyltransferase binding|norepinephrine metabolic process|surfactant homeostasis|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|post-translational protein modification|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|cell maturation|myoblast fate commitment|iron ion homeostasis|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to hypoxia hsa05200,hsa05211 Pathways in cancer|Renal cell carcinoma EPB41 738.43701124684 795.496108878671 681.377913615008 0.856544621664431 -0.223399689468756 0.164378681663526 1 1.70102 1.74541 1.48396 1.49667 GeneID:2035,Genbank:NM_203342.2,HGNC:HGNC:3377,MIM:130500 erythrocyte membrane protein band 4.1 GO:0003779,GO:0005200,GO:0005516,GO:0005545,GO:0005634,GO:0005829,GO:0005886,GO:0006461,GO:0007049,GO:0008022,GO:0008360,GO:0009898,GO:0014069,GO:0014731,GO:0030036,GO:0030054,GO:0030507,GO:0030863,GO:0030866,GO:0031032,GO:0032092,GO:0043234,GO:0047485,GO:0051219,GO:0051301,GO:0099738,GO:1904778 actin binding|structural constituent of cytoskeleton|calmodulin binding|1-phosphatidylinositol binding|nucleus|cytosol|plasma membrane|protein complex assembly|cell cycle|protein C-terminus binding|regulation of cell shape|cytoplasmic side of plasma membrane|postsynaptic density|spectrin-associated cytoskeleton|actin cytoskeleton organization|cell junction|spectrin binding|cortical cytoskeleton|cortical actin cytoskeleton organization|actomyosin structure organization|positive regulation of protein binding|protein complex|protein N-terminus binding|phosphoprotein binding|cell division|cell cortex region|positive regulation of protein localization to cell cortex EPB41L1 459.148664405092 409.413207036515 508.88412177367 1.24295971167409 0.313779534757269 0.076251040155894 0.94157495521624 1.15596 1.00064 1.54006 1.27847 GeneID:2036,Genbank:XM_011528667.1,HGNC:HGNC:3378,MIM:602879 erythrocyte membrane protein band 4.1 like 1 GO:0003779,GO:0005200,GO:0005829,GO:0005856,GO:0005886,GO:0030866,GO:0031032,GO:0045296 actin binding|structural constituent of cytoskeleton|cytosol|cytoskeleton|plasma membrane|cortical actin cytoskeleton organization|actomyosin structure organization|cadherin binding EPB41L2 4557.59512752212 4724.72609081443 4390.4641642298 0.929252633875542 -0.105857222616797 0.43836937865538 1 23.1532 21.9607 22.756 19.5117 GeneID:2037,Genbank:XM_017010353.2,HGNC:HGNC:3379,MIM:603237 erythrocyte membrane protein band 4.1 like 2 GO:0003779,GO:0005200,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0005925,GO:0007049,GO:0008091,GO:0030054,GO:0030507,GO:0030866,GO:0031032,GO:0042731,GO:0051301,GO:0070062,GO:0099738,GO:1904778 actin binding|structural constituent of cytoskeleton|nucleus|nucleoplasm|cytosol|plasma membrane|focal adhesion|cell cycle|spectrin|cell junction|spectrin binding|cortical actin cytoskeleton organization|actomyosin structure organization|PH domain binding|cell division|extracellular exosome|cell cortex region|positive regulation of protein localization to cell cortex EPB41L3 59.1120084422882 58.1155660782236 60.1084508063528 1.03429175456102 0.0486432006305016 0.918488424916897 1 0.309814 0.264491 0.405201 0.235322 GeneID:23136,Genbank:NM_001330557.1,HGNC:HGNC:3380,MIM:605331 erythrocyte membrane protein band 4.1 like 3 GO:0001558,GO:0002175,GO:0003779,GO:0005200,GO:0005737,GO:0005856,GO:0005886,GO:0005911,GO:0006915,GO:0007016,GO:0008360,GO:0014069,GO:0030865,GO:0030866,GO:0030913,GO:0031032,GO:0033270,GO:0043217,GO:0044224,GO:0048812,GO:0071205,GO:0072659 regulation of cell growth|protein localization to paranode region of axon|actin binding|structural constituent of cytoskeleton|cytoplasm|cytoskeleton|plasma membrane|cell-cell junction|apoptotic process|cytoskeletal anchoring at plasma membrane|regulation of cell shape|postsynaptic density|cortical cytoskeleton organization|cortical actin cytoskeleton organization|paranodal junction assembly|actomyosin structure organization|paranode region of axon|myelin maintenance|juxtaparanode region of axon|neuron projection morphogenesis|protein localization to juxtaparanode region of axon|protein localization to plasma membrane EPB41L4A 263.700098981497 243.378105324903 284.022092638092 1.16699935788772 0.222803767238526 0.276860291374436 1 1.0501 0.992227 1.38677 1.01093 GeneID:64097,Genbank:XM_011543531.3,HGNC:HGNC:13278,MIM:612141 erythrocyte membrane protein band 4.1 like 4A GO:0005200,GO:0005737,GO:0005856,GO:0008092,GO:0031032 structural constituent of cytoskeleton|cytoplasm|cytoskeleton|cytoskeletal protein binding|actomyosin structure organization EPB41L4B 60.28638054522 70.1752460284179 50.397515062022 0.718166560351114 -0.477609615845753 0.188602895964019 1 0.304996 0.453685 0.248852 0.29996 GeneID:54566,Genbank:NM_019114.4,HGNC:HGNC:19818,MIM:610340 erythrocyte membrane protein band 4.1 like 4B GO:0005200,GO:0005737,GO:0005856,GO:0005923,GO:0008092,GO:0010628,GO:0031032,GO:0042060,GO:0045177,GO:0045785,GO:0051549 structural constituent of cytoskeleton|cytoplasm|cytoskeleton|bicellular tight junction|cytoskeletal protein binding|positive regulation of gene expression|actomyosin structure organization|wound healing|apical part of cell|positive regulation of cell adhesion|positive regulation of keratinocyte migration hsa04530 Tight junction EPB41L5 267.054324512452 262.211524007384 271.897125017519 1.03693812103339 0.052329804332565 0.787500487692525 1 0.96112 0.807474 1.08269 0.88269 GeneID:57669,Genbank:NM_020909.3,HGNC:HGNC:19819,MIM:611730 erythrocyte membrane protein band 4.1 like 5 GO:0001701,GO:0001837,GO:0001839,GO:0003383,GO:0005200,GO:0005634,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0006931,GO:0007398,GO:0007492,GO:0007509,GO:0008092,GO:0009826,GO:0010608,GO:0010634,GO:0010718,GO:0019904,GO:0022408,GO:0031032,GO:0032091,GO:0032092,GO:0032525,GO:0032587,GO:0048319,GO:0048339,GO:0048617,GO:0051894,GO:0070201,GO:0070986,GO:0071560 in utero embryonic development|epithelial to mesenchymal transition|neural plate morphogenesis|apical constriction|structural constituent of cytoskeleton|nucleus|cytosol|cytoskeleton|plasma membrane|focal adhesion|substrate-dependent cell migration, cell attachment to substrate|ectoderm development|endoderm development|mesoderm migration involved in gastrulation|cytoskeletal protein binding|unidimensional cell growth|posttranscriptional regulation of gene expression|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|protein domain specific binding|negative regulation of cell-cell adhesion|actomyosin structure organization|negative regulation of protein binding|positive regulation of protein binding|somite rostral/caudal axis specification|ruffle membrane|axial mesoderm morphogenesis|paraxial mesoderm development|embryonic foregut morphogenesis|positive regulation of focal adhesion assembly|regulation of establishment of protein localization|left/right axis specification|cellular response to transforming growth factor beta stimulus EPB42 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0210602 GeneID:2038,Genbank:XM_011521351.2,HGNC:HGNC:3381,MIM:177070 erythrocyte membrane protein band 4.2 GO:0000902,GO:0003810,GO:0005200,GO:0005524,GO:0005856,GO:0005886,GO:0008360,GO:0018149,GO:0020027,GO:0030863,GO:0043249,GO:0048536,GO:0055072 cell morphogenesis|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton|ATP binding|cytoskeleton|plasma membrane|regulation of cell shape|peptide cross-linking|hemoglobin metabolic process|cortical cytoskeleton|erythrocyte maturation|spleen development|iron ion homeostasis EPC1 421.577985594058 424.431915707815 418.724055480301 0.98655176480309 -0.0195333431119615 0.940337156367952 1 3.6136 3.28318 3.59243 3.21313 GeneID:80314,Genbank:NM_001282391.1,HGNC:HGNC:19876,MIM:610999 enhancer of polycomb homolog 1 GO:0000122,GO:0005634,GO:0005654,GO:0006351,GO:0031965,GO:0032777,GO:0035267,GO:0035886,GO:0040008,GO:0043967,GO:0043968,GO:0045814,GO:0045892,GO:0045893,GO:0045944,GO:0070317 negative regulation of transcription from RNA polymerase II promoter|nucleus|nucleoplasm|transcription, DNA-templated|nuclear membrane|Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex|vascular smooth muscle cell differentiation|regulation of growth|histone H4 acetylation|histone H2A acetylation|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of G0 to G1 transition EPC2 189.878816347615 190.729759907365 189.027872787865 0.991076971311001 -0.0129309872067798 1 1 1.62136 1.21252 1.53836 1.11141 GeneID:26122,Genbank:XM_011510941.2,HGNC:HGNC:24543,MIM:611000 enhancer of polycomb homolog 2 GO:0006281,GO:0006351,GO:0006357,GO:0016573,GO:0032777 DNA repair|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|histone acetylation|Piccolo NuA4 histone acetyltransferase complex EPDR1 2490.97002080839 2190.45300820052 2791.48703341626 1.27438800237467 0.34980458990113 0.0110999901730346 0.424289839167833 40.6058 39.569 53.7787 50.1526 GeneID:54749,Genbank:NM_017549.4,HGNC:HGNC:17572 ependymin related 1 GO:0005509,GO:0005764,GO:0007160,GO:0070062 calcium ion binding|lysosome|cell-matrix adhesion|extracellular exosome EPG5 233.314243342549 236.882715585619 229.745771099479 0.969871400416464 -0.0441346282896678 0.84495229387643 1 0.584911 0.547586 0.646871 0.46278 GeneID:57724,Genbank:XM_017025890.2,HGNC:HGNC:29331,MIM:615068 ectopic P-granules autophagy protein 5 homolog GO:0005737,GO:0032456,GO:0097352 cytoplasm|endocytic recycling|autophagosome maturation EPGN 1.21180078441453 0 2.42360156882906 Inf Inf 0.339528558269803 1 0 0 0.0119976 0.0223962 GeneID:255324,Genbank:XM_011531817.3,HGNC:HGNC:17470 epithelial mitogen GO:0000165,GO:0000187,GO:0001525,GO:0005154,GO:0005615,GO:0005622,GO:0005887,GO:0008083,GO:0008284,GO:0043406,GO:0045741,GO:0045840,GO:0050679 MAPK cascade|activation of MAPK activity|angiogenesis|epidermal growth factor receptor binding|extracellular space|intracellular|integral component of plasma membrane|growth factor activity|positive regulation of cell proliferation|positive regulation of MAP kinase activity|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitotic nuclear division|positive regulation of epithelial cell proliferation EPHA1 35.3088068195061 35.2459063204983 35.3717073185139 1.00356923714407 0.00514015296224917 0.999841445434032 1 0.111618 0.0328533 0.115919 0.0215977 GeneID:2041,Genbank:XM_006715880.3,HGNC:HGNC:3385,MIM:179610 EPH receptor A1 hsa04360 Axon guidance EPHA2 15168.8209444844 15497.6886413416 14839.9532476272 0.957559129691129 -0.0625665180552381 0.607779897098065 1 129.073 135.484 138.418 120.903 GeneID:1969,Genbank:NM_001329090.1,HGNC:HGNC:3386,MIM:176946 EPH receptor A2 hsa04010,hsa04014,hsa04015,hsa04151,hsa04360 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance EPHA3 2944.21036289501 2781.91470072981 3106.5060250602 1.11667910746697 0.159214667847095 0.592066116711112 1 17.6246 14.7174 22.0465 14.2892 GeneID:2042,Genbank:NM_005233.5,HGNC:HGNC:3387,MIM:179611 EPH receptor A3 hsa04360 Axon guidance EPHA4 116.11118389143 117.845425186374 114.376942596485 0.970567524497418 -0.0430995070192947 0.906898161563581 1 0.603213 0.572889 0.638971 0.540614 GeneID:2043,Genbank:NM_001304536.1,HGNC:HGNC:3388,MIM:602188 EPH receptor A4 GO:0004672,GO:0005004,GO:0005005,GO:0005524,GO:0005737,GO:0005741,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0007155,GO:0007628,GO:0008045,GO:0008347,GO:0009986,GO:0010977,GO:0014069,GO:0016301,GO:0018108,GO:0021957,GO:0030054,GO:0030175,GO:0030424,GO:0030425,GO:0031594,GO:0031901,GO:0042731,GO:0042802,GO:0043087,GO:0043197,GO:0043198,GO:0043204,GO:0043507,GO:0043679,GO:0044295,GO:0045211,GO:0046777,GO:0046875,GO:0048013,GO:0048681,GO:0048710,GO:0050770,GO:0050775,GO:0050821,GO:0061001,GO:0061098,GO:0072178,GO:0097155,GO:0097156,GO:0097161,GO:0097485,GO:0106030,GO:1900272,GO:1902004,GO:1902961,GO:1903051,GO:1904646,GO:1905244,GO:1990782,GO:2001108 protein kinase activity|GPI-linked ephrin receptor activity|transmembrane-ephrin receptor activity|ATP binding|cytoplasm|mitochondrial outer membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell adhesion|adult walking behavior|motor neuron axon guidance|glial cell migration|cell surface|negative regulation of neuron projection development|postsynaptic density|kinase activity|peptidyl-tyrosine phosphorylation|corticospinal tract morphogenesis|cell junction|filopodium|axon|dendrite|neuromuscular junction|early endosome membrane|PH domain binding|identical protein binding|regulation of GTPase activity|dendritic spine|dendritic shaft|perikaryon|positive regulation of JUN kinase activity|axon terminus|axonal growth cone|postsynaptic membrane|protein autophosphorylation|ephrin receptor binding|ephrin receptor signaling pathway|negative regulation of axon regeneration|regulation of astrocyte differentiation|regulation of axonogenesis|positive regulation of dendrite morphogenesis|protein stabilization|regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|nephric duct morphogenesis|fasciculation of sensory neuron axon|fasciculation of motor neuron axon|DH domain binding|neuron projection guidance|neuron projection fasciculation|negative regulation of long-term synaptic potentiation|positive regulation of amyloid-beta formation|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of proteolysis involved in cellular protein catabolic process|cellular response to amyloid-beta|regulation of modification of synaptic structure|protein tyrosine kinase binding|positive regulation of Rho guanyl-nucleotide exchange factor activity hsa04360 Axon guidance EPHA5 56.9913393488721 49.5060032519468 64.4766754457975 1.30240114754693 0.381173875877376 0.548946373873874 1 0.171825 0.188907 0.363035 0.154669 GeneID:2044,Genbank:NM_182472.4,HGNC:HGNC:3389,MIM:600004 EPH receptor A5 GO:0005003,GO:0005004,GO:0005005,GO:0005524,GO:0005791,GO:0005886,GO:0005887,GO:0007411,GO:0009897,GO:0019933,GO:0021766,GO:0030424,GO:0030425,GO:0032793,GO:0032956,GO:0043025,GO:0043087,GO:0048013,GO:0048471,GO:0048666,GO:0061178 ephrin receptor activity|GPI-linked ephrin receptor activity|transmembrane-ephrin receptor activity|ATP binding|rough endoplasmic reticulum|plasma membrane|integral component of plasma membrane|axon guidance|external side of plasma membrane|cAMP-mediated signaling|hippocampus development|axon|dendrite|positive regulation of CREB transcription factor activity|regulation of actin cytoskeleton organization|neuronal cell body|regulation of GTPase activity|ephrin receptor signaling pathway|perinuclear region of cytoplasm|neuron development|regulation of insulin secretion involved in cellular response to glucose stimulus hsa04360 Axon guidance EPHA6 25.7837082865099 33.151350543722 18.4160660292979 0.555514804894893 -0.848102733833167 0.127280123232327 1 0.0310189 0.0458155 0.0245031 0.0227995 GeneID:285220,Genbank:XM_006713592.3,HGNC:HGNC:19296,MIM:600066 EPH receptor A6 GO:0005003,GO:0005524,GO:0005654,GO:0005886,GO:0005887,GO:0048013 ephrin receptor activity|ATP binding|nucleoplasm|plasma membrane|integral component of plasma membrane|ephrin receptor signaling pathway hsa04360 Axon guidance EPHB1 15.3964925102459 11.4059124139662 19.3870726065257 1.69973886374813 0.765313117590059 0.294646445930848 1 0.0598413 0.0446019 0.108015 0.0861208 GeneID:2047,Genbank:XM_024453390.1,HGNC:HGNC:3392,MIM:600600 EPH receptor B1 GO:0001525,GO:0001771,GO:0005005,GO:0005524,GO:0005576,GO:0005783,GO:0005829,GO:0005886,GO:0005887,GO:0007411,GO:0008046,GO:0014719,GO:0021631,GO:0021952,GO:0022008,GO:0030010,GO:0030424,GO:0030425,GO:0031290,GO:0031589,GO:0031901,GO:0032403,GO:0032433,GO:0045121,GO:0046328,GO:0046777,GO:0048013,GO:0048593,GO:0050965,GO:0051965,GO:0060326,GO:0060996,GO:0060997,GO:0061351,GO:0070062,GO:0070372,GO:1901214,GO:1902723,GO:1902725 angiogenesis|immunological synapse formation|transmembrane-ephrin receptor activity|ATP binding|extracellular region|endoplasmic reticulum|cytosol|plasma membrane|integral component of plasma membrane|axon guidance|axon guidance receptor activity|skeletal muscle satellite cell activation|optic nerve morphogenesis|central nervous system projection neuron axonogenesis|neurogenesis|establishment of cell polarity|axon|dendrite|retinal ganglion cell axon guidance|cell-substrate adhesion|early endosome membrane|protein complex binding|filopodium tip|membrane raft|regulation of JNK cascade|protein autophosphorylation|ephrin receptor signaling pathway|camera-type eye morphogenesis|detection of temperature stimulus involved in sensory perception of pain|positive regulation of synapse assembly|cell chemotaxis|dendritic spine development|dendritic spine morphogenesis|neural precursor cell proliferation|extracellular exosome|regulation of ERK1 and ERK2 cascade|regulation of neuron death|negative regulation of skeletal muscle satellite cell proliferation|negative regulation of satellite cell differentiation hsa04360 Axon guidance EPHB2 1644.87319522149 1678.7051900526 1611.04120039038 0.959692750065242 -0.059355500414745 0.662504151827275 1 4.45389 4.86613 5.19848 4.0062 GeneID:2048,Genbank:XM_006710442.4,HGNC:HGNC:3393,MIM:600997 EPH receptor B2 GO:0001525,GO:0001540,GO:0001655,GO:0001933,GO:0004713,GO:0005005,GO:0005102,GO:0005524,GO:0005576,GO:0005634,GO:0005829,GO:0005886,GO:0005887,GO:0007399,GO:0007411,GO:0007413,GO:0007611,GO:0007612,GO:0008046,GO:0010628,GO:0016310,GO:0018108,GO:0021631,GO:0021952,GO:0022038,GO:0030424,GO:0030425,GO:0031290,GO:0031915,GO:0042472,GO:0042802,GO:0043025,GO:0044877,GO:0046580,GO:0048013,GO:0048168,GO:0048170,GO:0048593,GO:0050771,GO:0050878,GO:0051389,GO:0051965,GO:0060021,GO:0060996,GO:0060997,GO:0070373,GO:0071679,GO:0098794,GO:0099557,GO:0106028,GO:1900273,GO:1903078,GO:1904782,GO:1904783 angiogenesis|amyloid-beta binding|urogenital system development|negative regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane-ephrin receptor activity|receptor binding|ATP binding|extracellular region|nucleus|cytosol|plasma membrane|integral component of plasma membrane|nervous system development|axon guidance|axonal fasciculation|learning or memory|learning|axon guidance receptor activity|positive regulation of gene expression|phosphorylation|peptidyl-tyrosine phosphorylation|optic nerve morphogenesis|central nervous system projection neuron axonogenesis|corpus callosum development|axon|dendrite|retinal ganglion cell axon guidance|positive regulation of synaptic plasticity|inner ear morphogenesis|identical protein binding|neuronal cell body|macromolecular complex binding|negative regulation of Ras protein signal transduction|ephrin receptor signaling pathway|regulation of neuronal synaptic plasticity|positive regulation of long-term neuronal synaptic plasticity|camera-type eye morphogenesis|negative regulation of axonogenesis|regulation of body fluid levels|inactivation of MAPKK activity|positive regulation of synapse assembly|palate development|dendritic spine development|dendritic spine morphogenesis|negative regulation of ERK1 and ERK2 cascade|commissural neuron axon guidance|postsynapse|trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission|neuron projection retraction|positive regulation of long-term synaptic potentiation|positive regulation of protein localization to plasma membrane|negative regulation of NMDA glutamate receptor activity|positive regulation of NMDA glutamate receptor activity hsa04360 Axon guidance EPHB3 155.35740394276 125.110252321473 185.604555564047 1.48352794531285 0.569032103214903 0.0245535555328801 0.624739213180639 1.17991 1.27745 1.86631 1.93126 GeneID:2049,Genbank:NM_004443.3,HGNC:HGNC:3394,MIM:601839 EPH receptor B3 GO:0001525,GO:0001655,GO:0005003,GO:0005524,GO:0005576,GO:0005829,GO:0005886,GO:0005887,GO:0007411,GO:0007413,GO:0008046,GO:0016477,GO:0021952,GO:0022038,GO:0022407,GO:0030425,GO:0031290,GO:0034446,GO:0043087,GO:0046777,GO:0048013,GO:0048538,GO:0048546,GO:0050770,GO:0051965,GO:0060021,GO:0060996,GO:0060997 angiogenesis|urogenital system development|ephrin receptor activity|ATP binding|extracellular region|cytosol|plasma membrane|integral component of plasma membrane|axon guidance|axonal fasciculation|axon guidance receptor activity|cell migration|central nervous system projection neuron axonogenesis|corpus callosum development|regulation of cell-cell adhesion|dendrite|retinal ganglion cell axon guidance|substrate adhesion-dependent cell spreading|regulation of GTPase activity|protein autophosphorylation|ephrin receptor signaling pathway|thymus development|digestive tract morphogenesis|regulation of axonogenesis|positive regulation of synapse assembly|palate development|dendritic spine development|dendritic spine morphogenesis hsa04360 Axon guidance EPHB4 3856.14226666025 3697.19624744505 4015.08828587545 1.0859819217468 0.119000086914539 0.387261053893776 1 32.7331 33.2783 37.2049 36.4381 GeneID:2050,Genbank:NM_004444.4,HGNC:HGNC:3395,MIM:600011 EPH receptor B4 GO:0001525,GO:0002042,GO:0003007,GO:0004714,GO:0005003,GO:0005524,GO:0005576,GO:0005829,GO:0005886,GO:0005887,GO:0007155,GO:0046777,GO:0048013,GO:0070062 angiogenesis|cell migration involved in sprouting angiogenesis|heart morphogenesis|transmembrane receptor protein tyrosine kinase activity|ephrin receptor activity|ATP binding|extracellular region|cytosol|plasma membrane|integral component of plasma membrane|cell adhesion|protein autophosphorylation|ephrin receptor signaling pathway|extracellular exosome hsa04360 Axon guidance EPHB6 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00948425 GeneID:2051,Genbank:XM_024446675.1,HGNC:HGNC:3396,MIM:602757 EPH receptor B6 hsa04360 Axon guidance EPHX1 6904.52571290086 5825.00941109186 7984.04201470985 1.37064877517739 0.454858932002771 0.000583406798594971 0.0687047300463019 90.4893 93.552 125.73 126.821 GeneID:2052,Genbank:NM_001136018.3,HGNC:HGNC:3401,MIM:132810 epoxide hydrolase 1 hsa00980,hsa04976,hsa05204 Metabolism of xenobiotics by cytochrome P450|Bile secretion|Chemical carcinogenesis EPHX3 1.48628770813257 1.51824048055703 1.45433493570811 0.957908153769244 -0.062040760902852 1 1 0.026216 0.0456711 0.0487376 0.0227475 GeneID:79852,Genbank:XM_024451725.1,HGNC:HGNC:23760,MIM:617400 epoxide hydrolase 3 GO:0004301,GO:0005783,GO:0006629,GO:0016020,GO:0016021,GO:0031090,GO:0043231,GO:0097176 epoxide hydrolase activity|endoplasmic reticulum|lipid metabolic process|membrane|integral component of membrane|organelle membrane|intracellular membrane-bounded organelle|epoxide metabolic process EPHX4 227.62856358122 234.768542498626 220.488584663813 0.939174313207243 -0.0905351441856707 0.693685326186146 1 7.72428 7.33941 7.06094 7.7504 GeneID:253152,Genbank:NM_173567.4,HGNC:HGNC:23758,MIM:617401 epoxide hydrolase 4 GO:0016021,GO:0016787 integral component of membrane|hydrolase activity EPM2A 125.749865010909 120.641774774064 130.857955247754 1.08468194779813 0.117272075296002 0.673597355118815 1 0.678375 0.678517 0.710934 0.607073 GeneID:7957,Genbank:XM_024446550.1,HGNC:HGNC:3413,MIM:607566 EPM2A, laforin glucan phosphatase EPM2AIP1 393.616558556977 417.897291348098 369.335825765856 0.883795691937635 -0.178215196192713 0.526540972859355 1 2.95105 2.43939 2.83966 2.02332 GeneID:9852,Genbank:NM_014805.3,HGNC:HGNC:19735,MIM:607911 EPM2A interacting protein 1 GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0005783,GO:0032868,GO:0042802,GO:0045725,GO:2000467 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|endoplasmic reticulum|response to insulin|identical protein binding|positive regulation of glycogen biosynthetic process|positive regulation of glycogen (starch) synthase activity EPN1 4303.03595987258 3758.44536403461 4847.62655571054 1.28979566979968 0.367142531140339 0.00658721837217434 0.320671396500742 50.8361 52.1827 67.8519 68.6297 GeneID:29924,Genbank:NM_001130072.1,HGNC:HGNC:21604,MIM:607262 epsin 1 hsa04144 Endocytosis EPN2 1206.22917133744 1205.25632549394 1207.20201718093 1.00161433849865 0.00232712027138277 1 1 8.96626 9.73574 9.63332 9.38191 GeneID:22905,Genbank:NM_014964.4,HGNC:HGNC:18639,MIM:607263 epsin 2 GO:0005829,GO:0006897,GO:0008289,GO:0030128,GO:0043231,GO:0045296,GO:0061024 cytosol|endocytosis|lipid binding|clathrin coat of endocytic vesicle|intracellular membrane-bounded organelle|cadherin binding|membrane organization hsa04144 Endocytosis EPN3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0105485 GeneID:55040,Genbank:NM_017957.2,HGNC:HGNC:18235,MIM:607264 epsin 3 GO:0005634,GO:0005654,GO:0005905,GO:0008289,GO:0019897,GO:0030136,GO:0043231,GO:0048471,GO:0070062,GO:1990175 nucleus|nucleoplasm|clathrin-coated pit|lipid binding|extrinsic component of plasma membrane|clathrin-coated vesicle|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|extracellular exosome|EH domain binding hsa04144 Endocytosis EPOP 252.991237290988 240.419076603798 265.563397978177 1.10458538369572 0.143504942344886 0.513175369358316 1 3.21686 3.45607 3.68077 3.91034 GeneID:100170841,Genbank:NM_001130677.1,HGNC:HGNC:34493,MIM:617795 elongin BC and polycomb repressive complex 2 associated protein GO:0003682,GO:0005694,GO:0006357,GO:0035098,GO:0035616,GO:0048663,GO:0048863,GO:0070449 chromatin binding|chromosome|regulation of transcription from RNA polymerase II promoter|ESC/E(Z) complex|histone H2B conserved C-terminal lysine deubiquitination|neuron fate commitment|stem cell differentiation|elongin complex EPOR 303.603328458337 299.005096773763 308.201560142911 1.03075687828862 0.043704088429252 0.824973165280336 1 5.59518 4.98587 5.52216 6.3098 GeneID:2057,Genbank:NM_000121.3,HGNC:HGNC:3416,MIM:133171 erythropoietin receptor GO:0004900,GO:0005576,GO:0005887,GO:0007165,GO:0007420,GO:0007507,GO:0042802,GO:0046697 erythropoietin receptor activity|extracellular region|integral component of plasma membrane|signal transduction|brain development|heart development|identical protein binding|decidualization hsa04060,hsa04151,hsa04630,hsa04640,hsa05200 Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Jak-STAT signaling pathway|Hematopoietic cell lineage|Pathways in cancer EPPK1 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0.00344079 0.00286279 0.00313789 0.0029389 GeneID:83481,Genbank:XM_017013890.1,HGNC:HGNC:15577,MIM:607553 epiplakin 1 GO:0003723,GO:0005737,GO:0005856,GO:0005923,GO:0008092,GO:0010839,GO:0016323,GO:0016327,GO:0019215,GO:0030056,GO:0030336,GO:0042060,GO:0042995,GO:0045095,GO:0045109,GO:0050680,GO:0051548,GO:0061045,GO:0071944,GO:0097356,GO:1905041 RNA binding|cytoplasm|cytoskeleton|bicellular tight junction|cytoskeletal protein binding|negative regulation of keratinocyte proliferation|basolateral plasma membrane|apicolateral plasma membrane|intermediate filament binding|hemidesmosome|negative regulation of cell migration|wound healing|cell projection|keratin filament|intermediate filament organization|negative regulation of epithelial cell proliferation|negative regulation of keratinocyte migration|negative regulation of wound healing|cell periphery|perinucleolar compartment|regulation of epithelium regeneration EPRS 2111.52971280634 2232.55686314586 1990.50256246682 0.891579782501951 -0.165564192528006 0.3293347827532 1 13.6066 11.9926 12.6312 10.2732 GeneID:2058,Genbank:NM_004446.2,HGNC:HGNC:3418,MIM:138295 glutamyl-prolyl-tRNA synthetase GO:0004818,GO:0004827,GO:0005524,GO:0005737,GO:0005829,GO:0006418,GO:0006424,GO:0006433,GO:0006461,GO:0008270,GO:0016020,GO:0017101,GO:0017148,GO:0030529,GO:0035613,GO:0042802,GO:0042803,GO:0051020,GO:0071346,GO:0097452 glutamate-tRNA ligase activity|proline-tRNA ligase activity|ATP binding|cytoplasm|cytosol|tRNA aminoacylation for protein translation|glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly|zinc ion binding|membrane|aminoacyl-tRNA synthetase multienzyme complex|negative regulation of translation|intracellular ribonucleoprotein complex|RNA stem-loop binding|identical protein binding|protein homodimerization activity|GTPase binding|cellular response to interferon-gamma|GAIT complex hsa00860,hsa00970 Porphyrin and chlorophyll metabolism|Aminoacyl-tRNA biosynthesis EPS15 625.968279204805 684.84685024164 567.08970816797 0.828053320195427 -0.272204425828475 0.195624798388226 1 4.07628 3.65625 3.83267 2.85214 GeneID:2060,Genbank:NM_001981.2,HGNC:HGNC:3419,MIM:600051 epidermal growth factor receptor pathway substrate 15 hsa04144 Endocytosis EPS15L1 1475.81907369739 1472.59990324007 1479.03824415471 1.00437209108902 0.00629384550332806 0.982523222215939 1 5.67566 6.06902 5.86124 5.81752 GeneID:58513,Genbank:NM_001258374.1,HGNC:HGNC:24634,MIM:616826 epidermal growth factor receptor pathway substrate 15 like 1 GO:0005509,GO:0005634,GO:0005829,GO:0005886,GO:0006897,GO:0016020,GO:0030132,GO:0042059,GO:0045296,GO:0061024 calcium ion binding|nucleus|cytosol|plasma membrane|endocytosis|membrane|clathrin coat of coated pit|negative regulation of epidermal growth factor receptor signaling pathway|cadherin binding|membrane organization hsa04144 Endocytosis EPS8 1029.53477918467 1087.29319644627 971.776361923058 0.893757419893022 -0.162044780935902 0.358149100149414 1 5.87021 5.30767 5.55034 4.2317 GeneID:2059,Genbank:NM_004447.5,HGNC:HGNC:3420,MIM:600206 epidermal growth factor receptor pathway substrate 8 EPS8L1 19.9721821870726 20.5633815719933 19.3809828021519 0.942499789458177 -0.0854357987847637 0.939579207702996 1 0.251843 0.228848 0.16293 0.279299 GeneID:54869,Genbank:NM_133180.2,HGNC:HGNC:21295,MIM:614987 EPS8 like 1 GO:0003779,GO:0005829,GO:0007266,GO:0032587,GO:0035023,GO:0042608,GO:0043234,GO:0045296,GO:0065009,GO:0070062,GO:1900029 actin binding|cytosol|Rho protein signal transduction|ruffle membrane|regulation of Rho protein signal transduction|T cell receptor binding|protein complex|cadherin binding|regulation of molecular function|extracellular exosome|positive regulation of ruffle assembly EPS8L2 11.2039953485826 16.1047126796921 6.30327801747302 0.391393385454271 -1.35330872025366 0.129524149348396 1 0.249762 0.106925 0.0767403 0.0358835 GeneID:64787,Genbank:NM_022772.3,HGNC:HGNC:21296,MIM:614988 EPS8 like 2 GO:0003779,GO:0005829,GO:0005886,GO:0007266,GO:0007605,GO:0031982,GO:0032421,GO:0032426,GO:0032587,GO:0035023,GO:0043234,GO:0045296,GO:0065009,GO:0070062,GO:1900029 actin binding|cytosol|plasma membrane|Rho protein signal transduction|sensory perception of sound|vesicle|stereocilium bundle|stereocilium tip|ruffle membrane|regulation of Rho protein signal transduction|protein complex|cadherin binding|regulation of molecular function|extracellular exosome|positive regulation of ruffle assembly EPSTI1 1.29177983152393 1.61429302992691 0.969266633120943 0.600427936658332 -0.735936990778882 0.974657200381333 1 0.0173151 0 0 0.00516308 GeneID:94240,Genbank:NM_001331228.1,HGNC:HGNC:16465,MIM:607441 epithelial stromal interaction 1 ERAL1 2167.41172171593 2154.62301193041 2180.20043150144 1.01187094885249 0.0170253045356331 0.919403290798524 1 38.4265 40.8254 39.2019 42.861 GeneID:26284,Genbank:NM_005702.3,HGNC:HGNC:3424,MIM:607435 Era like 12S mitochondrial rRNA chaperone 1 GO:0000028,GO:0003723,GO:0005525,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0019843,GO:0043024,GO:0070125,GO:0070126 ribosomal small subunit assembly|RNA binding|GTP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|rRNA binding|ribosomal small subunit binding|mitochondrial translational elongation|mitochondrial translational termination ERAP1 733.297101186253 712.867164047471 753.727038325035 1.05731765515131 0.0804088778209029 0.766569456329967 1 2.56207 2.49716 3.45236 2.15699 GeneID:51752,Genbank:NM_001349244.1,HGNC:HGNC:18173,MIM:606832 endoplasmic reticulum aminopeptidase 1 GO:0001525,GO:0002250,GO:0002474,GO:0004175,GO:0004177,GO:0005138,GO:0005151,GO:0005576,GO:0005615,GO:0005783,GO:0005788,GO:0005789,GO:0005829,GO:0005886,GO:0006509,GO:0007165,GO:0007267,GO:0008217,GO:0008235,GO:0008270,GO:0009617,GO:0016020,GO:0016021,GO:0019885,GO:0042277,GO:0043171,GO:0045088,GO:0045444,GO:0045766,GO:0070006,GO:0070062 angiogenesis|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|endopeptidase activity|aminopeptidase activity|interleukin-6 receptor binding|interleukin-1, Type II receptor binding|extracellular region|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|cytosol|plasma membrane|membrane protein ectodomain proteolysis|signal transduction|cell-cell signaling|regulation of blood pressure|metalloexopeptidase activity|zinc ion binding|response to bacterium|membrane|integral component of membrane|antigen processing and presentation of endogenous peptide antigen via MHC class I|peptide binding|peptide catabolic process|regulation of innate immune response|fat cell differentiation|positive regulation of angiogenesis|metalloaminopeptidase activity|extracellular exosome ERAP2 543.245913276097 529.535484443297 556.956342108897 1.05178285208672 0.0728368809090804 0.829436135082718 1 3.16895 2.74973 4.09491 2.39667 GeneID:64167,Genbank:NM_022350.4,HGNC:HGNC:29499,MIM:609497 endoplasmic reticulum aminopeptidase 2 GO:0002250,GO:0002474,GO:0004175,GO:0004177,GO:0005788,GO:0005789,GO:0005886,GO:0007165,GO:0007267,GO:0008217,GO:0008237,GO:0008270,GO:0016021,GO:0019885,GO:0042277,GO:0043171,GO:0070006 adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|endopeptidase activity|aminopeptidase activity|endoplasmic reticulum lumen|endoplasmic reticulum membrane|plasma membrane|signal transduction|cell-cell signaling|regulation of blood pressure|metallopeptidase activity|zinc ion binding|integral component of membrane|antigen processing and presentation of endogenous peptide antigen via MHC class I|peptide binding|peptide catabolic process|metalloaminopeptidase activity ERBB2 1775.52860800249 1639.25055486834 1911.80666113665 1.16626872899867 0.2219002493656 0.125125161804283 1 9.482 10.1104 11.7386 11.7206 GeneID:2064,Genbank:NM_001289936.1,HGNC:HGNC:3430,MIM:164870 erb-b2 receptor tyrosine kinase 2 hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04020,hsa04066,hsa04151,hsa04510,hsa04520,hsa04530,hsa05200,hsa05205,hsa05206,hsa05212,hsa05213,hsa05215,hsa05219,hsa05223,hsa05224,hsa05226,hsa05230 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Adherens junction|Tight junction|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Pancreatic cancer|Endometrial cancer|Prostate cancer|Bladder cancer|Non-small cell lung cancer|Breast cancer|Gastric cancer|Central carbon metabolism in cancer ERBB3 22.1053316963982 19.9772576206661 24.2334057721304 1.21304967039427 0.278638625284775 0.673845308878353 1 0.100021 0.102326 0.136012 0.110198 GeneID:2065,Genbank:NM_001982.3,HGNC:HGNC:3431,MIM:190151 erb-b2 receptor tyrosine kinase 3 hsa01521,hsa04010,hsa04012,hsa04020,hsa04151,hsa05205,hsa05206 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Proteoglycans in cancer|MicroRNAs in cancer ERBB4 27.5607377465227 25.5601481409368 29.5613273521087 1.15653975043922 0.209814852464379 0.731458500028034 1 0.0497897 0.0673742 0.0545738 0.0895787 GeneID:2066,Genbank:NM_001042599.1,HGNC:HGNC:3432,MIM:600543 erb-b2 receptor tyrosine kinase 4 GO:0000165,GO:0001755,GO:0001934,GO:0004713,GO:0004714,GO:0004716,GO:0005088,GO:0005154,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006351,GO:0007165,GO:0007169,GO:0007399,GO:0007507,GO:0007595,GO:0008283,GO:0008284,GO:0008285,GO:0009880,GO:0014068,GO:0016021,GO:0016323,GO:0016477,GO:0018108,GO:0021551,GO:0021889,GO:0030334,GO:0038083,GO:0038128,GO:0042531,GO:0042803,GO:0043065,GO:0043066,GO:0043235,GO:0043552,GO:0043653,GO:0044212,GO:0045165,GO:0045893,GO:0046777,GO:0046934,GO:0051897,GO:0060045,GO:0060644,GO:0060749,GO:0061026,GO:0070374,GO:0071364,GO:1901185,GO:2000010,GO:2000145,GO:2000366,GO:2001223 MAPK cascade|neural crest cell migration|positive regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|signal transducer, downstream of receptor, with protein tyrosine kinase activity|Ras guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|ATP binding|extracellular region|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|plasma membrane|transcription, DNA-templated|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|nervous system development|heart development|lactation|cell proliferation|positive regulation of cell proliferation|negative regulation of cell proliferation|embryonic pattern specification|positive regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|basolateral plasma membrane|cell migration|peptidyl-tyrosine phosphorylation|central nervous system morphogenesis|olfactory bulb interneuron differentiation|regulation of cell migration|peptidyl-tyrosine autophosphorylation|ERBB2 signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|receptor complex|positive regulation of phosphatidylinositol 3-kinase activity|mitochondrial fragmentation involved in apoptotic process|transcription regulatory region DNA binding|cell fate commitment|positive regulation of transcription, DNA-templated|protein autophosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|positive regulation of protein kinase B signaling|positive regulation of cardiac muscle cell proliferation|mammary gland epithelial cell differentiation|mammary gland alveolus development|cardiac muscle tissue regeneration|positive regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|negative regulation of ERBB signaling pathway|positive regulation of protein localization to cell surface|regulation of cell motility|positive regulation of STAT protein import into nucleus|negative regulation of neuron migration hsa04010,hsa04012,hsa04020,hsa04151,hsa05205 MAPK signaling pathway|ErbB signaling pathway|Calcium signaling pathway|PI3K-Akt signaling pathway|Proteoglycans in cancer ERBIN 1273.59200922154 1291.27246751499 1255.91155092809 0.972615449119772 -0.0400585872183557 0.931938812369637 1 6.33035 5.18486 7.11397 4.37718 GeneID:55914,Genbank:NM_001253699.1,HGNC:HGNC:15842,MIM:606944 erbb2 interacting protein GO:0005102,GO:0005176,GO:0005178,GO:0005200,GO:0005604,GO:0005634,GO:0005737,GO:0005886,GO:0006605,GO:0007049,GO:0007155,GO:0007165,GO:0007173,GO:0007229,GO:0009925,GO:0016049,GO:0016323,GO:0016607,GO:0030054,GO:0030056,GO:0031965,GO:0032088,GO:0032495,GO:0032496,GO:0038128,GO:0045104,GO:0045175,GO:0045197,GO:0070433,GO:0071356,GO:0071638 receptor binding|ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton|basement membrane|nucleus|cytoplasm|plasma membrane|protein targeting|cell cycle|cell adhesion|signal transduction|epidermal growth factor receptor signaling pathway|integrin-mediated signaling pathway|basal plasma membrane|cell growth|basolateral plasma membrane|nuclear speck|cell junction|hemidesmosome|nuclear membrane|negative regulation of NF-kappaB transcription factor activity|response to muramyl dipeptide|response to lipopolysaccharide|ERBB2 signaling pathway|intermediate filament cytoskeleton organization|basal protein localization|establishment or maintenance of epithelial cell apical/basal polarity|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to tumor necrosis factor|negative regulation of monocyte chemotactic protein-1 production hsa04621 NOD-like receptor signaling pathway ERC1 1005.58485335993 988.043092570665 1023.12661414919 1.03550808850578 0.0503388227053092 0.755497492970095 1 2.77131 3.03198 3.24006 2.68852 GeneID:23085,Genbank:XM_017019055.2,HGNC:HGNC:17072,MIM:607127 ELKS/RAB6-interacting/CAST family member 1 GO:0000139,GO:0005737,GO:0007252,GO:0008385,GO:0015031,GO:0017137,GO:0030165,GO:0042147,GO:0045202,GO:0045296,GO:0048786 Golgi membrane|cytoplasm|I-kappaB phosphorylation|IkappaB kinase complex|protein transport|Rab GTPase binding|PDZ domain binding|retrograde transport, endosome to Golgi|synapse|cadherin binding|presynaptic active zone hsa04064 NF-kappa B signaling pathway ERC2 21.1522709529929 23.4077574343676 18.8967844716181 0.807287264685747 -0.308845962161787 0.627597684927048 1 0.0916695 0.125307 0.0439037 0.0862511 GeneID:26059,Genbank:XM_017006155.1,HGNC:HGNC:31922,MIM:617250 ELKS/RAB6-interacting/CAST family member 2 GO:0005737,GO:0005856,GO:0030054,GO:0030426,GO:0042734,GO:0048786 cytoplasm|cytoskeleton|cell junction|growth cone|presynaptic membrane|presynaptic active zone ERCC1 2752.39280129085 2811.31629519812 2693.46930738357 0.958081206296196 -0.0617801519158406 0.641468043830393 1 19.2352 19.6546 18.6074 18.6637 GeneID:2067,Genbank:NM_001166049.1,HGNC:HGNC:3433,MIM:126380 ERCC excision repair 1, endonuclease non-catalytic subunit hsa01524,hsa03420,hsa03460 Platinum drug resistance|Nucleotide excision repair|Fanconi anemia pathway ERCC2 2751.76643372531 2992.19086013997 2511.34200731065 0.839298736175265 -0.25274368650113 0.0617914128379063 0.887969225260202 20.7194 23.4083 18.6631 18.4648 GeneID:2068,Genbank:XM_011526611.2,HGNC:HGNC:3434,MIM:126340 ERCC excision repair 2, TFIIH core complex helicase subunit hsa03022,hsa03420 Basal transcription factors|Nucleotide excision repair ERCC3 2427.15192380856 2469.0300105721 2385.27383704503 0.966077296278932 -0.049789470529218 0.720806752476528 1 24.3383 24.0398 23.6839 24.1648 GeneID:2071,Genbank:NM_000122.1,HGNC:HGNC:3435,MIM:133510 ERCC excision repair 3, TFIIH core complex helicase subunit hsa03022,hsa03420 Basal transcription factors|Nucleotide excision repair ERCC4 178.919831782545 194.516060954077 163.323602611012 0.839640705296677 -0.252155985539161 0.299520111373316 1 1.02725 0.889113 0.859839 0.794989 GeneID:2072,Genbank:XM_011522424.3,HGNC:HGNC:3436,MIM:133520 ERCC excision repair 4, endonuclease catalytic subunit hsa03420,hsa03460 Nucleotide excision repair|Fanconi anemia pathway ERCC5 16.7181585505359 14.0483745224928 19.3879425785791 1.38008440389577 0.464756502770243 0.50756163433323 1 2.22648 1.3935 2.56491 1.8873 GeneID:2073,Genbank:NM_000123.3,HGNC:HGNC:3437,MIM:133530 ERCC excision repair 5, endonuclease hsa03420 Nucleotide excision repair ERCC6 139.631729316267 133.863893971804 145.399564660729 1.08617462369169 0.119256063070189 0.657778598494381 1 0.536648 0.615189 0.687991 0.565254 GeneID:2074,Genbank:NM_001346440.1,HGNC:HGNC:3438,MIM:609413 ERCC excision repair 6, chromatin remodeling factor GO:0003677,GO:0005654,GO:0016604 DNA binding|nucleoplasm|nuclear body hsa03420 Nucleotide excision repair ERCC6L 381.190948040723 418.253092581109 344.128803500338 0.822776471003866 -0.281427557285334 0.209451995131922 1 3.46508 3.08362 3.14999 2.28249 GeneID:54821,Genbank:NM_017669.3,HGNC:HGNC:20794,MIM:300687 ERCC excision repair 6 like, spindle assembly checkpoint helicase GO:0000777,GO:0003677,GO:0004386,GO:0005524,GO:0005829,GO:0007062,GO:0015616,GO:0016020,GO:0051301 condensed chromosome kinetochore|DNA binding|helicase activity|ATP binding|cytosol|sister chromatid cohesion|DNA translocase activity|membrane|cell division ERCC6L2 135.940362844666 136.640626249278 135.240099440054 0.989750289883265 -0.0148635100878257 0.995120015269941 1 0.285721 0.252815 0.341928 0.191471 GeneID:375748,Genbank:NM_020207.4,HGNC:HGNC:26922,MIM:615667 ERCC excision repair 6 like 2 GO:0003677,GO:0004386,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005815,GO:0019901,GO:0034614,GO:0036297,GO:0043234 DNA binding|helicase activity|ATP binding|nucleus|cytoplasm|mitochondrion|microtubule organizing center|protein kinase binding|cellular response to reactive oxygen species|interstrand cross-link repair|protein complex ERCC8 380.612697402094 389.993664402707 371.231730401481 0.951891695394692 -0.0711306593852404 0.703287105673572 1 3.92594 4.47601 4.1105 3.36479 GeneID:1161,Genbank:NM_001290285.1,HGNC:HGNC:3439,MIM:609412 ERCC excision repair 8, CSA ubiquitin ligase complex subunit hsa03420,hsa04120 Nucleotide excision repair|Ubiquitin mediated proteolysis EREG 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0.0105279 0.0196039 GeneID:2069,Genbank:NM_001432.2,HGNC:HGNC:3443,MIM:602061 epiregulin GO:0000165,GO:0001525,GO:0001550,GO:0001556,GO:0001819,GO:0004713,GO:0005088,GO:0005154,GO:0005576,GO:0005615,GO:0005622,GO:0005887,GO:0007143,GO:0007173,GO:0007267,GO:0008083,GO:0008284,GO:0008285,GO:0009299,GO:0009653,GO:0009887,GO:0019221,GO:0030216,GO:0030728,GO:0038128,GO:0042060,GO:0042108,GO:0042327,GO:0042700,GO:0043434,GO:0043616,GO:0045089,GO:0045410,GO:0045740,GO:0045741,GO:0045840,GO:0045860,GO:0045892,GO:0046934,GO:0048146,GO:0048160,GO:0048661,GO:0050680,GO:0051151,GO:0051781,GO:0051897,GO:1901185,GO:2000145 MAPK cascade|angiogenesis|ovarian cumulus expansion|oocyte maturation|positive regulation of cytokine production|protein tyrosine kinase activity|Ras guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|extracellular region|extracellular space|intracellular|integral component of plasma membrane|female meiotic nuclear division|epidermal growth factor receptor signaling pathway|cell-cell signaling|growth factor activity|positive regulation of cell proliferation|negative regulation of cell proliferation|mRNA transcription|anatomical structure morphogenesis|animal organ morphogenesis|cytokine-mediated signaling pathway|keratinocyte differentiation|ovulation|ERBB2 signaling pathway|wound healing|positive regulation of cytokine biosynthetic process|positive regulation of phosphorylation|luteinizing hormone signaling pathway|response to peptide hormone|keratinocyte proliferation|positive regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of DNA replication|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitotic nuclear division|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|positive regulation of fibroblast proliferation|primary follicle stage|positive regulation of smooth muscle cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|positive regulation of cell division|positive regulation of protein kinase B signaling|negative regulation of ERBB signaling pathway|regulation of cell motility hsa04010,hsa04012,hsa04151,hsa05210 MAPK signaling pathway|ErbB signaling pathway|PI3K-Akt signaling pathway|Colorectal cancer ERF 1894.18511743128 1904.25944546426 1884.1107893983 0.989419164434787 -0.0153462510131621 0.898791104497066 1 27.1715 28.563 26.9096 29.4331 GeneID:2077,Genbank:NM_001312656.1,HGNC:HGNC:3444,MIM:611888 ETS2 repressor factor GO:0000122,GO:0000981,GO:0001227,GO:0003714,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0007049,GO:0030154,GO:0043565 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|transcription corepressor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|cell cycle|cell differentiation|sequence-specific DNA binding ERFE 182.556315737846 182.889634476902 182.222996998791 0.996354973970954 -0.00526826830717029 0.974634168047611 1 2.642 2.90617 3.02356 2.69602 GeneID:151176,Genbank:NM_001291832.1,HGNC:HGNC:26727,MIM:615099 erythroferrone GO:0005179,GO:0005576,GO:0005615,GO:0005623,GO:0006879,GO:0019217,GO:0042803,GO:2000193 hormone activity|extracellular region|extracellular space|cell|cellular iron ion homeostasis|regulation of fatty acid metabolic process|protein homodimerization activity|positive regulation of fatty acid transport ERG 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.0058877 0 0.0112126 0 GeneID:2078,Genbank:NM_001243432.2,HGNC:HGNC:3446,MIM:165080 ERG, ETS transcription factor hsa05202,hsa05215 Transcriptional misregulation in cancer|Prostate cancer ERG28 895.995204147596 848.922683346277 943.067724948915 1.11089942988864 0.151728214955328 0.332571469424644 1 28.2061 28.4737 32.2758 32.4087 GeneID:11161,Genbank:NM_007176.3,HGNC:HGNC:1187,MIM:604576 ergosterol biosynthesis 28 homolog GO:0005789,GO:0006696,GO:0016021,GO:0030133,GO:0030674 endoplasmic reticulum membrane|ergosterol biosynthetic process|integral component of membrane|transport vesicle|protein binding, bridging ERGIC1 6174.59453191628 5810.44153920209 6538.74752463047 1.12534434440389 0.170366519620591 0.201793979833734 1 46.13 48.3154 56.6648 51.8899 GeneID:57222,Genbank:NM_001031711.2,HGNC:HGNC:29205 endoplasmic reticulum-golgi intermediate compartment 1 GO:0000139,GO:0005654,GO:0005789,GO:0005793,GO:0006888,GO:0016020,GO:0016021,GO:0033116,GO:0043231 Golgi membrane|nucleoplasm|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|ER to Golgi vesicle-mediated transport|membrane|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|intracellular membrane-bounded organelle ERGIC2 358.072271656678 345.849020606967 370.295522706389 1.07068547442036 0.0985347348625938 0.59288969165474 1 2.1882 2.09465 2.67003 1.9242 GeneID:51290,Genbank:XM_024449009.1,HGNC:HGNC:30208,MIM:612236 ERGIC and golgi 2 GO:0005634,GO:0005730,GO:0005737,GO:0005789,GO:0005794,GO:0006890,GO:0016020,GO:0016021,GO:0033116,GO:0043231 nucleus|nucleolus|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|retrograde vesicle-mediated transport, Golgi to ER|membrane|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|intracellular membrane-bounded organelle ERGIC3 5794.08170595845 5660.16820859483 5927.99520332208 1.04731785078764 0.0666993526445725 0.7051757572196 1 115.296 123.717 118.221 136.621 GeneID:51614,Genbank:NM_198398.1,HGNC:HGNC:15927,MIM:616971 ERGIC and golgi 3 GO:0005789,GO:0005794,GO:0016020,GO:0016021,GO:0016192,GO:0033116 endoplasmic reticulum membrane|Golgi apparatus|membrane|integral component of membrane|vesicle-mediated transport|endoplasmic reticulum-Golgi intermediate compartment membrane ERH 3198.7372845716 3477.70107729709 2919.77349184611 0.839569999534115 -0.252277479349052 0.0657802594019459 0.9056040615812 192.817 187.585 157.888 163.681 GeneID:2079,Genbank:NM_004450.2,HGNC:HGNC:3447,MIM:601191 ERH, mRNA splicing and mitosis factor GO:0001649,GO:0006221,GO:0007049,GO:0008327,GO:0016020,GO:0030496,GO:0034709,GO:0045747 osteoblast differentiation|pyrimidine nucleotide biosynthetic process|cell cycle|methyl-CpG binding|membrane|midbody|methylosome|positive regulation of Notch signaling pathway ERI1 821.115422457949 855.628778493662 786.602066422235 0.91932633192522 -0.121351031108452 0.456316414421483 1 4.03866 3.88673 4.06125 3.1862 GeneID:90459,Genbank:XM_017013949.1,HGNC:HGNC:23994,MIM:608739 exoribonuclease 1 GO:0000175,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006259,GO:0006364,GO:0008408,GO:0019843,GO:0031047,GO:0031125,GO:0043022,GO:0046872,GO:0071204,GO:0071207 3'-5'-exoribonuclease activity|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA metabolic process|rRNA processing|3'-5' exonuclease activity|rRNA binding|gene silencing by RNA|rRNA 3'-end processing|ribosome binding|metal ion binding|histone pre-mRNA 3'end processing complex|histone pre-mRNA stem-loop binding ERI2 199.166620645879 218.990205086621 179.343036205137 0.818954601801473 -0.288144615635491 0.319263432509271 1 1.86607 1.71876 1.74935 1.11252 GeneID:112479,Genbank:NM_080663.2,HGNC:HGNC:30541 ERI1 exoribonuclease family member 2 GO:0003676,GO:0004527,GO:0006259,GO:0008270 nucleic acid binding|exonuclease activity|DNA metabolic process|zinc ion binding ERI3 1770.08311302765 1768.99196387063 1771.17426218467 1.00123363947299 0.00177866865743498 0.995600004959009 1 40.1559 42.7803 39.6411 45.8003 GeneID:79033,Genbank:NM_001301699.1,HGNC:HGNC:17276,MIM:609917 ERI1 exoribonuclease family member 3 GO:0003723,GO:0004527,GO:0006259,GO:0046872 RNA binding|exonuclease activity|DNA metabolic process|metal ion binding ERICH1 508.975236188093 540.606229935324 477.344242440863 0.882979544090661 -0.179548079415439 0.298433228862513 1 0.430625 0.441243 0.42861 0.383432 GeneID:157697,Genbank:NM_001303100.1,HGNC:HGNC:27234 glutamate rich 1 GO:0003964,GO:0004519,GO:0006310,GO:0046872 RNA-directed DNA polymerase activity|endonuclease activity|DNA recombination|metal ion binding ERICH2 30.3066117598246 22.8118248279324 37.8013986917168 1.65709665828356 0.72865775727226 0.152404118273882 1 0.129546 0.0609475 0.196702 0.195378 GeneID:285141,Genbank:XM_017003875.1,HGNC:HGNC:44395 glutamate rich 2 ERICH3 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00346684 0 0.00333418 0 GeneID:127254,Genbank:NM_001002912.4,HGNC:HGNC:25346 glutamate rich 3 ERICH4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.021711 0 GeneID:100170765,Genbank:XM_017026119.1,HGNC:HGNC:34497 glutamate rich 4 ERICH5 0.975139704544532 0.980142803914724 0.97013660517434 0.989791080748215 -0.0148040531050533 1 1 0 0.0373361 0.0378583 0 GeneID:203111,Genbank:NM_173549.2,HGNC:HGNC:26823 glutamate rich 5 ERICH6 1.53344401076412 1.61429302992691 1.45259499160132 0.899833527539349 -0.152269972565186 1 1 0.0402616 0 0 0 GeneID:131831,Genbank:NM_001308234.1,HGNC:HGNC:28602 glutamate rich 6 ERLEC1 1045.70671461983 1070.22795827288 1021.18547096678 0.954175662365201 -0.06767320612626 0.672100848776178 1 5.63801 5.52263 5.94225 4.7769 GeneID:27248,Genbank:NM_015701.4,HGNC:HGNC:25222,MIM:611229 endoplasmic reticulum lectin 1 GO:0005788,GO:0030433,GO:0036503,GO:0044322,GO:0051082,GO:0055085,GO:1904153 endoplasmic reticulum lumen|ubiquitin-dependent ERAD pathway|ERAD pathway|endoplasmic reticulum quality control compartment|unfolded protein binding|transmembrane transport|negative regulation of retrograde protein transport, ER to cytosol hsa04141 Protein processing in endoplasmic reticulum ERLIN1 1918.98469658637 1996.0056078322 1841.96378534053 0.922824955056627 -0.115871076941839 0.405092190891271 1 20.2343 21.9078 18.7672 20.5732 GeneID:10613,Genbank:NM_001347857.1,HGNC:HGNC:16947,MIM:611604 ER lipid raft associated 1 GO:0005783,GO:0005789,GO:0008203,GO:0015485,GO:0016021,GO:0030433,GO:0031625,GO:0032933,GO:0043234,GO:0045541,GO:0045717,GO:0055085 endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol metabolic process|cholesterol binding|integral component of membrane|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|SREBP signaling pathway|protein complex|negative regulation of cholesterol biosynthetic process|negative regulation of fatty acid biosynthetic process|transmembrane transport ERLIN2 1589.62101981468 1465.5829821318 1713.65905749756 1.16926784657728 0.225605448831306 0.111780406830081 1 9.25861 8.5936 10.9557 10.1706 GeneID:11160,Genbank:NM_007175.6,HGNC:HGNC:1356,MIM:611605 ER lipid raft associated 2 GO:0004713,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0008203,GO:0015485,GO:0016021,GO:0030433,GO:0031625,GO:0032933,GO:0043234,GO:0045121,GO:0045541,GO:0045717,GO:0055085,GO:0070062 protein tyrosine kinase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|cholesterol metabolic process|cholesterol binding|integral component of membrane|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|SREBP signaling pathway|protein complex|membrane raft|negative regulation of cholesterol biosynthetic process|negative regulation of fatty acid biosynthetic process|transmembrane transport|extracellular exosome ERMAP 293.660870363832 294.133808719513 293.187932008151 0.996784195888666 -0.00464690041569499 0.97502651085547 1 2.36433 2.70718 2.56147 2.64682 GeneID:114625,Genbank:NM_001017922.1,HGNC:HGNC:15743,MIM:609017 erythroblast membrane associated protein (Scianna blood group) ERMARD 293.628853671666 291.154145687337 296.103561655994 1.01699929759534 0.0243186827784357 0.885929528432076 1 3.05173 2.59079 2.86881 3.14529 GeneID:55780,Genbank:NM_001278531.1,HGNC:HGNC:21056,MIM:615532 ER membrane associated RNA degradation GO:0005789,GO:0007275,GO:0016021 endoplasmic reticulum membrane|multicellular organism development|integral component of membrane ERMN 1.94853946498227 1.96028560782945 1.93679332213509 0.988015886256305 -0.0173938558720137 1 1 0 0.0369179 0 0.0255876 GeneID:57471,Genbank:NM_001009959.2,HGNC:HGNC:29208,MIM:610072 ermin GO:0001763,GO:0005737,GO:0005856,GO:0005938,GO:0007015,GO:0008360,GO:0030175,GO:0031344,GO:0033269,GO:0033270,GO:0043025,GO:0043209,GO:0051015,GO:0070062 morphogenesis of a branching structure|cytoplasm|cytoskeleton|cell cortex|actin filament organization|regulation of cell shape|filopodium|regulation of cell projection organization|internode region of axon|paranode region of axon|neuronal cell body|myelin sheath|actin filament binding|extracellular exosome ERMP1 1033.79618230265 1107.01172238415 960.580642221151 0.867724002192464 -0.204691858653518 0.182444456111705 1 9.45728 9.14886 8.82482 7.61396 GeneID:79956,Genbank:NM_024896.2,HGNC:HGNC:23703,MIM:611156 endoplasmic reticulum metallopeptidase 1 GO:0005789,GO:0008237,GO:0016020,GO:0016021,GO:0046872 endoplasmic reticulum membrane|metallopeptidase activity|membrane|integral component of membrane|metal ion binding ERN1 158.872248256365 171.858123605307 145.886372907423 0.848876793525737 -0.236372919516734 0.343724888401456 1 0.650136 0.638417 0.598964 0.447201 GeneID:2081,Genbank:XM_017024347.2,HGNC:HGNC:3449,MIM:604033 endoplasmic reticulum to nucleus signaling 1 GO:0000287,GO:0001935,GO:0004521,GO:0004674,GO:0005161,GO:0005524,GO:0005637,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0006351,GO:0006355,GO:0006379,GO:0006402,GO:0006468,GO:0006987,GO:0007050,GO:0007257,GO:0016241,GO:0019899,GO:0030176,GO:0030544,GO:0033120,GO:0034976,GO:0035924,GO:0036289,GO:0036498,GO:0042802,GO:0042803,GO:0043531,GO:0046777,GO:0051879,GO:0070054,GO:0070055,GO:0070059,GO:0071333,GO:1900103,GO:1901142,GO:1904707,GO:1990332,GO:1990579,GO:1990597,GO:1990604,GO:1990630 magnesium ion binding|endothelial cell proliferation|endoribonuclease activity|protein serine/threonine kinase activity|platelet-derived growth factor receptor binding|ATP binding|nuclear inner membrane|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA cleavage|mRNA catabolic process|protein phosphorylation|activation of signaling protein activity involved in unfolded protein response|cell cycle arrest|activation of JUN kinase activity|regulation of macroautophagy|enzyme binding|integral component of endoplasmic reticulum membrane|Hsp70 protein binding|positive regulation of RNA splicing|response to endoplasmic reticulum stress|cellular response to vascular endothelial growth factor stimulus|peptidyl-serine autophosphorylation|IRE1-mediated unfolded protein response|identical protein binding|protein homodimerization activity|ADP binding|protein autophosphorylation|Hsp90 protein binding|mRNA splicing, via endonucleolytic cleavage and ligation|mRNA endonucleolytic cleavage involved in unfolded protein response|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to glucose stimulus|positive regulation of endoplasmic reticulum unfolded protein response|insulin metabolic process|positive regulation of vascular smooth muscle cell proliferation|Ire1 complex|peptidyl-serine trans-autophosphorylation|AIP1-IRE1 complex|IRE1-TRAF2-ASK1 complex|IRE1-RACK1-PP2A complex hsa04140,hsa04141,hsa04210,hsa04932,hsa05010 Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease ERN2 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0 0 0 0 GeneID:10595,Genbank:NM_001308220.1,HGNC:HGNC:16942,MIM:604034 endoplasmic reticulum to nucleus signaling 2 GO:0000287,GO:0004519,GO:0004540,GO:0004674,GO:0005524,GO:0006351,GO:0006397,GO:0006468,GO:0007050,GO:0007257,GO:0016021,GO:0016075,GO:0030263,GO:0034976,GO:0045892,GO:0070059,GO:1990604 magnesium ion binding|endonuclease activity|ribonuclease activity|protein serine/threonine kinase activity|ATP binding|transcription, DNA-templated|mRNA processing|protein phosphorylation|cell cycle arrest|activation of JUN kinase activity|integral component of membrane|rRNA catabolic process|apoptotic chromosome condensation|response to endoplasmic reticulum stress|negative regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|IRE1-TRAF2-ASK1 complex ERO1A 924.636974547861 799.445089058799 1049.82886003692 1.31319695924695 0.393083314417056 0.0496721584983605 0.815111977981293 5.9868 6.0849 8.95736 6.84212 GeneID:30001,Genbank:NM_014584.2,HGNC:HGNC:13280,MIM:615435 endoplasmic reticulum oxidoreductase 1 alpha GO:0003756,GO:0005783,GO:0005788,GO:0005789,GO:0006457,GO:0006464,GO:0009266,GO:0010260,GO:0015035,GO:0015036,GO:0016020,GO:0016491,GO:0016671,GO:0019471,GO:0022417,GO:0030198,GO:0030425,GO:0030968,GO:0034599,GO:0034975,GO:0034976,GO:0043231,GO:0045454,GO:0050873,GO:0051085,GO:0051209,GO:0070059,GO:0071456 protein disulfide isomerase activity|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|protein folding|cellular protein modification process|response to temperature stimulus|animal organ senescence|protein disulfide oxidoreductase activity|disulfide oxidoreductase activity|membrane|oxidoreductase activity|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|4-hydroxyproline metabolic process|protein maturation by protein folding|extracellular matrix organization|dendrite|endoplasmic reticulum unfolded protein response|cellular response to oxidative stress|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|intracellular membrane-bounded organelle|cell redox homeostasis|brown fat cell differentiation|chaperone cofactor-dependent protein refolding|release of sequestered calcium ion into cytosol|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to hypoxia hsa04141,hsa05110 Protein processing in endoplasmic reticulum|Vibrio cholerae infection ERO1B 119.151520298755 110.350275332959 127.952765264552 1.15951468973214 0.213521097404755 0.43137292431277 1 0.627803 0.518578 0.730423 0.607081 GeneID:56605,Genbank:XM_024448449.1,HGNC:HGNC:14355,MIM:615437 endoplasmic reticulum oxidoreductase 1 beta GO:0003756,GO:0005783,GO:0005789,GO:0006457,GO:0006464,GO:0015035,GO:0016491,GO:0016671,GO:0019471,GO:0022417,GO:0030070,GO:0030198,GO:0034975,GO:0042593,GO:0045454,GO:0051082 protein disulfide isomerase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|cellular protein modification process|protein disulfide oxidoreductase activity|oxidoreductase activity|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|4-hydroxyproline metabolic process|protein maturation by protein folding|insulin processing|extracellular matrix organization|protein folding in endoplasmic reticulum|glucose homeostasis|cell redox homeostasis|unfolded protein binding hsa04141 Protein processing in endoplasmic reticulum ERP29 4562.63820751695 4392.6728150523 4732.60359998159 1.07738586488037 0.107535042499808 0.434657798636546 1 112.231 125.608 123.623 134.575 GeneID:10961,Genbank:XM_017018720.1,HGNC:HGNC:13799,MIM:602287 endoplasmic reticulum protein 29 GO:0000187,GO:0001934,GO:0005783,GO:0005788,GO:0005790,GO:0006457,GO:0006886,GO:0009306,GO:0009986,GO:0010628,GO:0010629,GO:0016020,GO:0030133,GO:0042470,GO:0042803,GO:0043335,GO:0050709,GO:0051087,GO:0070062,GO:1902235 activation of MAPK activity|positive regulation of protein phosphorylation|endoplasmic reticulum|endoplasmic reticulum lumen|smooth endoplasmic reticulum|protein folding|intracellular protein transport|protein secretion|cell surface|positive regulation of gene expression|negative regulation of gene expression|membrane|transport vesicle|melanosome|protein homodimerization activity|protein unfolding|negative regulation of protein secretion|chaperone binding|extracellular exosome|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway hsa04141 Protein processing in endoplasmic reticulum ERP44 683.522422859447 703.066753009179 663.978092709715 0.944402632990165 -0.0825260310881099 0.608925507223452 1 4.79962 5.31852 5.18631 4.38773 GeneID:23071,Genbank:NM_015051.2,HGNC:HGNC:18311,MIM:609170 endoplasmic reticulum protein 44 GO:0003756,GO:0005576,GO:0005788,GO:0005789,GO:0005793,GO:0006457,GO:0006986,GO:0009100,GO:0009986,GO:0034976,GO:0035580,GO:0043312,GO:0045454,GO:0070062 protein disulfide isomerase activity|extracellular region|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|protein folding|response to unfolded protein|glycoprotein metabolic process|cell surface|response to endoplasmic reticulum stress|specific granule lumen|neutrophil degranulation|cell redox homeostasis|extracellular exosome ERRFI1 4757.73603357252 5058.73797953612 4456.73408760893 0.880997218206901 -0.182790631116752 0.17384336566464 1 30.8504 30.4357 28.4764 25.8324 GeneID:54206,Genbank:NM_018948.3,HGNC:HGNC:18185,MIM:608069 ERBB receptor feedback inhibitor 1 ERV3-1 54.6355131974249 45.7775371350276 63.4934892598222 1.38700098855338 0.471968815909927 0.224672996666937 1 0.763429 0.595269 1.11349 1.04913 GeneID:2086,Genbank:NM_001007253.3,HGNC:HGNC:3454,MIM:131170 endogenous retrovirus group 3 member 1, envelope GO:0019031,GO:0070062 viral envelope|extracellular exosome ERVMER34-1 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0407606 0 GeneID:100288413,Genbank:NM_001242690.1,HGNC:HGNC:42970 endogenous retrovirus group MER34 member 1, envelope GO:0016021,GO:0019031 integral component of membrane|viral envelope ESAM 7.93203699300871 6.65908587355536 9.20498811246207 1.38232007924947 0.467091713612614 0.699351704454234 1 0.095807 0.0846273 0.111847 0.229946 GeneID:90952,Genbank:NM_138961.2,HGNC:HGNC:17474,MIM:614281 endothelial cell adhesion molecule GO:0005886,GO:0005912,GO:0005923,GO:0007156,GO:0016021,GO:0050900,GO:0070062 plasma membrane|adherens junction|bicellular tight junction|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|leukocyte migration|extracellular exosome hsa04514,hsa04670 Cell adhesion molecules (CAMs)|Leukocyte transendothelial migration ESCO1 45.6369018972149 53.95486348914 37.3189403052898 0.691669627017059 -0.531844989504451 0.213629005723932 1 0.361591 0.394668 0.297392 0.233896 GeneID:114799,Genbank:XM_011525799.3,HGNC:HGNC:24645,MIM:609674 establishment of sister chromatid cohesion N-acetyltransferase 1 GO:0000785,GO:0005654,GO:0006275,GO:0007062,GO:0008080,GO:0008270,GO:0018394,GO:0034421,GO:0042802,GO:0061733 chromatin|nucleoplasm|regulation of DNA replication|sister chromatid cohesion|N-acetyltransferase activity|zinc ion binding|peptidyl-lysine acetylation|post-translational protein acetylation|identical protein binding|peptide-lysine-N-acetyltransferase activity ESCO2 342.926784613987 380.037331883542 305.816237344432 0.804700516732776 -0.313476135777324 0.282546346926036 1 4.60713 3.5761 3.5387 3.00297 GeneID:157570,Genbank:XM_011544421.2,HGNC:HGNC:27230,MIM:609353 establishment of sister chromatid cohesion N-acetyltransferase 2 GO:0000785,GO:0001741,GO:0002244,GO:0004468,GO:0005634,GO:0005654,GO:0005794,GO:0006275,GO:0006302,GO:0007049,GO:0007059,GO:0008080,GO:0010369,GO:0030054,GO:0031618,GO:0034421,GO:0035861,GO:0046872,GO:0071168 chromatin|XY body|hematopoietic progenitor cell differentiation|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|nucleus|nucleoplasm|Golgi apparatus|regulation of DNA replication|double-strand break repair|cell cycle|chromosome segregation|N-acetyltransferase activity|chromocenter|cell junction|nuclear pericentric heterochromatin|post-translational protein acetylation|site of double-strand break|metal ion binding|protein localization to chromatin ESD 1082.70352336522 1062.88669589863 1102.52035083182 1.03728869228124 0.0528174727035614 0.7142965834131 1 12.0597 11.7939 12.859 12.1795 GeneID:2098,Genbank:XM_011534954.2,HGNC:HGNC:3465,MIM:133280 esterase D GO:0005788,GO:0016788,GO:0018738,GO:0031410,GO:0042802,GO:0046294,GO:0047374,GO:0052689,GO:0070062,GO:1901687 endoplasmic reticulum lumen|hydrolase activity, acting on ester bonds|S-formylglutathione hydrolase activity|cytoplasmic vesicle|identical protein binding|formaldehyde catabolic process|methylumbelliferyl-acetate deacetylase activity|carboxylic ester hydrolase activity|extracellular exosome|glutathione derivative biosynthetic process ESF1 63.7940723719916 69.415617287712 58.1725274562711 0.83803227183242 -0.254922293067603 0.66876724024173 1 0.517044 0.348829 0.526156 0.221043 GeneID:51575,Genbank:NM_001276380.1,HGNC:HGNC:15898 ESF1 nucleolar pre-rRNA processing protein homolog GO:0003723,GO:0005615,GO:0005654,GO:0005730,GO:0006351,GO:0006355 RNA binding|extracellular space|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated ESM1 2.0803512945418 4.16070258908361 0 0 -Inf 0.115301259557465 1 0.110112 0.0639491 0 0 GeneID:11082,Genbank:NM_001135604.1,HGNC:HGNC:3466,MIM:601521 endothelial cell specific molecule 1 GO:0001525,GO:0001558,GO:0002040,GO:0005171,GO:0005178,GO:0005520,GO:0005576,GO:0008284,GO:1902204 angiogenesis|regulation of cell growth|sprouting angiogenesis|hepatocyte growth factor receptor binding|integrin binding|insulin-like growth factor binding|extracellular region|positive regulation of cell proliferation|positive regulation of hepatocyte growth factor receptor signaling pathway ESPL1 1846.0997422295 1849.18813500055 1843.01134945846 0.996659731140826 -0.00482705564581931 0.970304007308907 1 11.0405 10.8351 11.0672 10.9614 GeneID:9700,Genbank:XM_011539025.2,HGNC:HGNC:16856,MIM:604143 extra spindle pole bodies like 1, separase GO:0000070,GO:0000212,GO:0000910,GO:0003824,GO:0004197,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0006915,GO:0008234,GO:0040001,GO:0045143,GO:0045842,GO:0045875,GO:0051307,GO:0072686 mitotic sister chromatid segregation|meiotic spindle organization|cytokinesis|catalytic activity|cysteine-type endopeptidase activity|nucleus|cytoplasm|centrosome|cytosol|apoptotic process|cysteine-type peptidase activity|establishment of mitotic spindle localization|homologous chromosome segregation|positive regulation of mitotic metaphase/anaphase transition|negative regulation of sister chromatid cohesion|meiotic chromosome separation|mitotic spindle hsa04110,hsa04114 Cell cycle|Oocyte meiosis ESPN 3.76158186530972 5.58289052027075 1.94027321034868 0.347539183027824 -1.52475245238031 0.370684772116822 1 0.00723692 0.0182559 0.00661601 0 GeneID:83715,Genbank:XM_017002433.1,HGNC:HGNC:13281,MIM:606351 espin GO:0005737,GO:0005902,GO:0005903,GO:0007605,GO:0007626,GO:0017124,GO:0030046,GO:0031941,GO:0032426,GO:0051015,GO:0051017,GO:0051491,GO:0051494 cytoplasm|microvillus|brush border|sensory perception of sound|locomotory behavior|SH3 domain binding|parallel actin filament bundle assembly|filamentous actin|stereocilium tip|actin filament binding|actin filament bundle assembly|positive regulation of filopodium assembly|negative regulation of cytoskeleton organization ESPNL 1.26820168020816 1.56626675524197 0.97013660517434 0.619394239153384 -0.691070129994731 0.974558099637673 1 0.0211277 0.00892596 0.0194091 0 GeneID:339768,Genbank:NM_194312.3,HGNC:HGNC:27937 espin like GO:0005737,GO:0007605,GO:0032426,GO:0051015,GO:0051017 cytoplasm|sensory perception of sound|stereocilium tip|actin filament binding|actin filament bundle assembly ESR1 0.999152841887003 1.02816907859967 0.97013660517434 0.943557460895085 -0.0838177169406569 1 1 0.00227186 0.0021662 0 0 GeneID:2099,Genbank:XM_017010377.1,HGNC:HGNC:3467,MIM:133430 estrogen receptor 1 hsa01522,hsa04915,hsa04917,hsa04919,hsa04961,hsa05200,hsa05205,hsa05224 Endocrine resistance|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Endocrine and other factor-regulated calcium reabsorption|Pathways in cancer|Proteoglycans in cancer|Breast cancer ESR2 8.82056297344196 4.55472144167109 13.0864045052128 2.87315144796463 1.52263404141512 0.138341202146628 1 0.010631 0.0199208 0.0508599 0.0567053 GeneID:2100,Genbank:NM_001291712.1,HGNC:HGNC:3468,MIM:601663 estrogen receptor 2 hsa01522,hsa04915,hsa04917,hsa05200,hsa05224 Endocrine resistance|Estrogen signaling pathway|Prolactin signaling pathway|Pathways in cancer|Breast cancer ESRP1 1.21386734807293 0.490071401957362 1.93766329418849 3.95383873951713 1.98325403079315 0.683591311517638 1 0 0.0108767 0 0.0102545 GeneID:54845,Genbank:XM_005250991.3,HGNC:HGNC:25966,MIM:612959 epithelial splicing regulatory protein 1 GO:0003729,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0008543,GO:0016604,GO:0043484 mRNA binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|fibroblast growth factor receptor signaling pathway|nuclear body|regulation of RNA splicing ESRP2 32.9888708155773 36.4181542231528 29.5595874080019 0.811671762024924 -0.301031671709207 0.60903263461428 1 0.248265 0.142581 0.141964 0.184509 GeneID:80004,Genbank:XM_005256153.5,HGNC:HGNC:26152,MIM:612960 epithelial splicing regulatory protein 2 GO:0000380,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0008543,GO:0043484,GO:0050679,GO:0060441,GO:0060445 alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|fibroblast growth factor receptor signaling pathway|regulation of RNA splicing|positive regulation of epithelial cell proliferation|epithelial tube branching involved in lung morphogenesis|branching involved in salivary gland morphogenesis ESRRA 1235.11990053563 1246.60461970199 1223.63518136927 0.981574399797893 -0.0268304719727758 0.837432604311732 1 18.2005 19.506 18.4257 19.2623 GeneID:2101,Genbank:NM_004451.4,HGNC:HGNC:3471,MIM:601998 estrogen related receptor alpha ESRRB 5.42769477149196 4.55472144167109 6.30066810131283 1.38332677025385 0.46814199100731 0.789127438978839 1 0.00762351 0.0270364 0.0355722 0.0399218 GeneID:2103,Genbank:NM_004452.3,HGNC:HGNC:3473,MIM:602167 estrogen related receptor beta GO:0000793,GO:0000980,GO:0000993,GO:0001047,GO:0001158,GO:0001191,GO:0001205,GO:0003700,GO:0003705,GO:0003707,GO:0003713,GO:0004879,GO:0005496,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006367,GO:0008134,GO:0008270,GO:0008283,GO:0017145,GO:0019827,GO:0035326,GO:0043565,GO:0043697,GO:0045494,GO:0045725,GO:0045821,GO:0045893,GO:0045944,GO:0048839,GO:0071931,GO:0090282,GO:1902459,GO:2000035,GO:2000737 condensed chromosome|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II core binding|core promoter binding|enhancer sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|steroid hormone receptor activity|transcription coactivator activity|nuclear receptor activity|steroid binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|transcription factor binding|zinc ion binding|cell proliferation|stem cell division|stem cell population maintenance|enhancer binding|sequence-specific DNA binding|cell dedifferentiation|photoreceptor cell maintenance|positive regulation of glycogen biosynthetic process|positive regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|inner ear development|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|positive regulation of transcription involved in G2/M transition of mitotic cell cycle|positive regulation of stem cell population maintenance|regulation of stem cell division|negative regulation of stem cell differentiation hsa04550 Signaling pathways regulating pluripotency of stem cells ESRRG 10.0533448992069 9.44562680613677 10.661062992277 1.12867713398867 0.174632852090234 0.874314594027201 1 0.0130865 0.00754835 0.0201636 0.0211391 GeneID:2104,Genbank:NM_001243511.2,HGNC:HGNC:3474,MIM:602969 estrogen related receptor gamma GO:0000977,GO:0001228,GO:0003707,GO:0003708,GO:0005496,GO:0005634,GO:0006355,GO:0008270,GO:0045893,GO:0045944,GO:0050682 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|steroid hormone receptor activity|retinoic acid receptor activity|steroid binding|nucleus|regulation of transcription, DNA-templated|zinc ion binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|AF-2 domain binding ESS2 574.343744048551 559.891502400185 588.795985696917 1.05162515089588 0.0726205512896509 0.674044180755925 1 2.11366 2.02051 2.1657 2.30387 GeneID:8220,Genbank:NM_022719.2,HGNC:HGNC:16817,MIM:601755 ess-2 splicing factor homolog GO:0000398,GO:0005634,GO:0007399,GO:0071013 mRNA splicing, via spliceosome|nucleus|nervous system development|catalytic step 2 spliceosome ESYT1 3254.71655426685 3224.53542059157 3284.89768794213 1.01871967879934 0.026757119567692 0.859712958715193 1 25.487 26.7288 28.5022 25.4184 GeneID:23344,Genbank:NM_001184796.1,HGNC:HGNC:29534,MIM:616670 extended synaptotagmin 1 GO:0005783,GO:0005789,GO:0005886,GO:0006687,GO:0006869,GO:0008289,GO:0016020,GO:0030176,GO:0042802,GO:0044232,GO:0046872,GO:0061817 endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|glycosphingolipid metabolic process|lipid transport|lipid binding|membrane|integral component of endoplasmic reticulum membrane|identical protein binding|organelle membrane contact site|metal ion binding|endoplasmic reticulum-plasma membrane tethering ESYT2 4800.62822323016 4801.34194265491 4799.91450380542 0.999702700022924 -0.000428976973165522 1 1 23.895 24.1815 25.5766 22.8978 GeneID:57488,Genbank:XM_024446846.1,HGNC:HGNC:22211,MIM:616691 extended synaptotagmin 2 GO:0005509,GO:0005544,GO:0005789,GO:0005887,GO:0006687,GO:0006869,GO:0006897,GO:0008429,GO:0016020,GO:0031210,GO:0031227,GO:0031234,GO:0035091,GO:0042802,GO:0044232,GO:0045296,GO:0061817 calcium ion binding|calcium-dependent phospholipid binding|endoplasmic reticulum membrane|integral component of plasma membrane|glycosphingolipid metabolic process|lipid transport|endocytosis|phosphatidylethanolamine binding|membrane|phosphatidylcholine binding|intrinsic component of endoplasmic reticulum membrane|extrinsic component of cytoplasmic side of plasma membrane|phosphatidylinositol binding|identical protein binding|organelle membrane contact site|cadherin binding|endoplasmic reticulum-plasma membrane tethering ESYT3 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0189559 0 GeneID:83850,Genbank:NM_031913.4,HGNC:HGNC:24295,MIM:616692 extended synaptotagmin 3 GO:0005789,GO:0005887,GO:0006687,GO:0006869,GO:0008289,GO:0031227,GO:0031234,GO:0044232,GO:0046872,GO:0061817 endoplasmic reticulum membrane|integral component of plasma membrane|glycosphingolipid metabolic process|lipid transport|lipid binding|intrinsic component of endoplasmic reticulum membrane|extrinsic component of cytoplasmic side of plasma membrane|organelle membrane contact site|metal ion binding|endoplasmic reticulum-plasma membrane tethering ETAA1 80.7932039180616 70.4535950214196 91.1328128147036 1.29351543788499 0.371297272443383 0.409296715347506 1 0.698775 0.645668 1.19224 0.571272 GeneID:54465,Genbank:NM_019002.3,HGNC:HGNC:24648,MIM:613196 ETAA1, ATR kinase activator GO:0006281,GO:0006974,GO:0031297,GO:0043539,GO:0043596,GO:0071902,GO:2000001 DNA repair|cellular response to DNA damage stimulus|replication fork processing|protein serine/threonine kinase activator activity|nuclear replication fork|positive regulation of protein serine/threonine kinase activity|regulation of DNA damage checkpoint ETF1 4737.43935031253 4957.04427630327 4517.83442432179 0.911396826919402 -0.133848747143427 0.323992242013817 1 40.0805 38.0014 37.9708 34.2267 GeneID:2107,Genbank:NM_004730.3,HGNC:HGNC:3477,MIM:600285 eukaryotic translation termination factor 1 GO:0000184,GO:0003747,GO:0005737,GO:0006415,GO:0006479,GO:0016032,GO:1990825 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translation release factor activity|cytoplasm|translational termination|protein methylation|viral process|sequence-specific mRNA binding hsa03015 mRNA surveillance pathway ETFA 2601.36620731942 2570.83633266197 2631.89608197687 1.02375092826375 0.0338647599990347 0.79199590481323 1 72.2858 66.2824 69.2497 70.9046 GeneID:2108,Genbank:NM_001127716.1,HGNC:HGNC:3481,MIM:608053 electron transfer flavoprotein alpha subunit GO:0005739,GO:0005759,GO:0009055,GO:0016491,GO:0022904,GO:0033539,GO:0050660,GO:0070062 mitochondrion|mitochondrial matrix|electron transfer activity|oxidoreductase activity|respiratory electron transport chain|fatty acid beta-oxidation using acyl-CoA dehydrogenase|flavin adenine dinucleotide binding|extracellular exosome ETFB 1428.76336148833 1266.59168597777 1590.9350369989 1.25607569875271 0.328923412417626 0.0380759488807245 0.746313200357312 19.0471 20.9111 24.5562 25.9463 GeneID:2109,Genbank:NM_001985.2,HGNC:HGNC:3482,MIM:130410 electron transfer flavoprotein beta subunit GO:0005739,GO:0005759,GO:0005829,GO:0006479,GO:0009055,GO:0022904,GO:0033539,GO:0070062 mitochondrion|mitochondrial matrix|cytosol|protein methylation|electron transfer activity|respiratory electron transport chain|fatty acid beta-oxidation using acyl-CoA dehydrogenase|extracellular exosome ETFBKMT 30.1262432092731 25.8483057890465 34.4041806294998 1.33100331256832 0.412514161798221 0.42448790341325 1 0.149185 0.100176 0.137933 0.163652 GeneID:254013,Genbank:NM_001135864.1,HGNC:HGNC:28739,MIM:615256 electron transfer flavoprotein beta subunit lysine methyltransferase GO:0005737,GO:0005759,GO:0006479,GO:0016279,GO:0018022,GO:0018023,GO:0031072,GO:0043234,GO:1904733,GO:1904736 cytoplasm|mitochondrial matrix|protein methylation|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|peptidyl-lysine trimethylation|heat shock protein binding|protein complex|negative regulation of electron transfer activity|negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase ETFDH 330.552245559859 332.992511297345 328.111979822374 0.985343419718489 -0.021301463134893 0.922129786275302 1 4.19227 4.38629 4.80655 4.12175 GeneID:2110,Genbank:NM_004453.3,HGNC:HGNC:3483,MIM:231675 electron transfer flavoprotein dehydrogenase GO:0004174,GO:0005759,GO:0006979,GO:0009055,GO:0016491,GO:0017133,GO:0022900,GO:0022904,GO:0031305,GO:0031966,GO:0033539,GO:0043783,GO:0046872,GO:0048038,GO:0048039,GO:0050660,GO:0051539 electron-transferring-flavoprotein dehydrogenase activity|mitochondrial matrix|response to oxidative stress|electron transfer activity|oxidoreductase activity|mitochondrial electron transfer flavoprotein complex|electron transport chain|respiratory electron transport chain|integral component of mitochondrial inner membrane|mitochondrial membrane|fatty acid beta-oxidation using acyl-CoA dehydrogenase|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|metal ion binding|quinone binding|ubiquinone binding|flavin adenine dinucleotide binding|4 iron, 4 sulfur cluster binding ETFRF1 100.997625885437 100.712543428082 101.282708342791 1.00566130985577 0.00814451104509809 0.990239907509733 1 1.15766 1.1868 1.19992 1.23827 GeneID:144363,Genbank:NM_001001660.2,HGNC:HGNC:27052 electron transfer flavoprotein regulatory factor 1 GO:0005739,GO:0022904 mitochondrion|respiratory electron transport chain ETHE1 803.982025317282 810.323729452086 797.640321182478 0.984347726953296 -0.0227600482936674 0.870036379573881 1 25.0944 25.8533 24.8264 26.9732 GeneID:23474,Genbank:NM_001320869.1,HGNC:HGNC:23287,MIM:608451 ETHE1, persulfide dioxygenase GO:0005506,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006749,GO:0050313,GO:0070221,GO:0070813 iron ion binding|nucleoplasm|cytoplasm|mitochondrion|mitochondrial matrix|glutathione metabolic process|sulfur dioxygenase activity|sulfide oxidation, using sulfide:quinone oxidoreductase|hydrogen sulfide metabolic process hsa00920 Sulfur metabolism ETNK1 324.557014169977 358.302719409749 290.811308930205 0.811635784984479 -0.30109562003242 0.124633479515284 1 1.32103 1.4243 1.24285 0.893035 GeneID:55500,Genbank:NM_018638.4,HGNC:HGNC:24649,MIM:609858 ethanolamine kinase 1 GO:0004305,GO:0005524,GO:0005654,GO:0005829,GO:0005886,GO:0006646,GO:0016020 ethanolamine kinase activity|ATP binding|nucleoplasm|cytosol|plasma membrane|phosphatidylethanolamine biosynthetic process|membrane hsa00564 Glycerophospholipid metabolism ETNK2 733.567121891333 686.404325342629 780.729918440038 1.13741986991461 0.185764912477233 0.248625020564442 1 6.94928 6.57841 7.82237 7.81585 GeneID:55224,Genbank:NM_001297761.1,HGNC:HGNC:25575,MIM:609859 ethanolamine kinase 2 GO:0001701,GO:0001890,GO:0004305,GO:0005524,GO:0005829,GO:0006646,GO:0009791,GO:0035264 in utero embryonic development|placenta development|ethanolamine kinase activity|ATP binding|cytosol|phosphatidylethanolamine biosynthetic process|post-embryonic development|multicellular organism growth hsa00564 Glycerophospholipid metabolism ETNPPL 11.6549359486118 14.5864721991351 8.72339969808849 0.598047257691667 -0.741668604203763 0.41256600014869 1 0.208961 0.111895 0.0998869 0.052979 GeneID:64850,Genbank:NM_001331033.1,HGNC:HGNC:14404,MIM:614682 ethanolamine-phosphate phospho-lyase GO:0005739,GO:0005759,GO:0006646,GO:0008453,GO:0030170,GO:0042802,GO:0050459 mitochondrion|mitochondrial matrix|phosphatidylethanolamine biosynthetic process|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding|identical protein binding|ethanolamine-phosphate phospho-lyase activity hsa00564 Glycerophospholipid metabolism ETS1 2288.63758524052 2449.62703424594 2127.64813623509 0.868560032401029 -0.203302527524378 0.150613969469252 1 17.4122 16.1805 16.0172 13.3013 GeneID:2113,Genbank:NM_001143820.1,HGNC:HGNC:3488,MIM:164720 ETS proto-oncogene 1, transcription factor GO:0003700,GO:0005634,GO:0006351,GO:0010595,GO:0043565,GO:0045765 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|positive regulation of endothelial cell migration|sequence-specific DNA binding|regulation of angiogenesis hsa04014,hsa04218,hsa05166,hsa05200,hsa05211 Ras signaling pathway|Cellular senescence|Human T-cell leukemia virus 1 infection|Pathways in cancer|Renal cell carcinoma ETS2 1454.40835016624 1546.95445216693 1361.86224816554 0.880350579332105 -0.183849936656669 0.201676040749754 1 8.62251 9.14436 8.38528 7.27272 GeneID:2114,Genbank:NM_001256295.1,HGNC:HGNC:3489,MIM:164740 ETS proto-oncogene 2, transcription factor hsa04014,hsa05166 Ras signaling pathway|Human T-cell leukemia virus 1 infection ETV1 393.920672031468 371.505221297274 416.336122765661 1.1206736780491 0.164366249957942 0.364207353213108 1 1.65835 1.52642 2.04856 1.53972 GeneID:2115,Genbank:NM_001163148.1,HGNC:HGNC:3490,MIM:600541 ETS variant 1 GO:0000978,GO:0001077,GO:0003700,GO:0005634,GO:0006366,GO:0007411,GO:0007517,GO:0007638,GO:0045944,GO:0048935 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription from RNA polymerase II promoter|axon guidance|muscle organ development|mechanosensory behavior|positive regulation of transcription from RNA polymerase II promoter|peripheral nervous system neuron development hsa05202 Transcriptional misregulation in cancer ETV2 36.1769448444604 42.7890824485985 29.5648072403223 0.690942772045597 -0.533361871835448 0.27089767683126 1 0.532452 0.251795 0.388398 0.227036 GeneID:2116,Genbank:XM_011526624.2,HGNC:HGNC:3491,MIM:609358 ETS variant 2 GO:0000978,GO:0000981,GO:0001077,GO:0001824,GO:0001890,GO:0005634,GO:0006357,GO:0007219,GO:0016055,GO:0030154,GO:0030218,GO:0045603,GO:0048514,GO:0060803,GO:2000382 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|blastocyst development|placenta development|nucleus|regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|Wnt signaling pathway|cell differentiation|erythrocyte differentiation|positive regulation of endothelial cell differentiation|blood vessel morphogenesis|BMP signaling pathway involved in mesodermal cell fate specification|positive regulation of mesoderm development ETV3 421.717124058307 443.611326968198 399.822921148416 0.901291055575501 -0.149935021448056 0.432995320125995 1 2.84413 2.41607 2.47842 2.27917 GeneID:2117,Genbank:NM_001145312.2,HGNC:HGNC:3492,MIM:164873 ETS variant 3 GO:0000790,GO:0000977,GO:0000981,GO:0001227,GO:0005634,GO:0006351,GO:0006357,GO:0008285,GO:0017151,GO:0030154,GO:0090571,GO:0097011 nuclear chromatin|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|negative regulation of cell proliferation|DEAD/H-box RNA helicase binding|cell differentiation|RNA polymerase II transcription repressor complex|cellular response to granulocyte macrophage colony-stimulating factor stimulus ETV4 522.431037631716 434.704814839558 610.157260423874 1.40361284162236 0.48914505209762 0.00488171663315481 0.278240475432767 4.7951 5.07768 7.57797 6.79699 GeneID:2118,Genbank:NM_001261437.1,HGNC:HGNC:3493,MIM:600711 ETS variant 4 hsa05202 Transcriptional misregulation in cancer ETV5 2846.04525462681 2708.14358610515 2983.94692314848 1.10184221341085 0.139917641124971 0.314188664916577 1 25.8249 27.8685 31.799 28.4462 GeneID:2119,Genbank:NM_004454.2,HGNC:HGNC:3494,MIM:601600 ETS variant 5 GO:0000977,GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005886,GO:0007274,GO:0007626,GO:0030154,GO:0034599,GO:0044212,GO:0045666,GO:0045944,GO:0048133,GO:0050807,GO:0060252,GO:0060762,GO:0071340 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|plasma membrane|neuromuscular synaptic transmission|locomotory behavior|cell differentiation|cellular response to oxidative stress|transcription regulatory region DNA binding|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|male germ-line stem cell asymmetric division|regulation of synapse organization|positive regulation of glial cell proliferation|regulation of branching involved in mammary gland duct morphogenesis|skeletal muscle acetylcholine-gated channel clustering hsa05202,hsa05215 Transcriptional misregulation in cancer|Prostate cancer ETV6 549.630514099981 513.786572996616 585.474455203346 1.13952852404962 0.188437037801882 0.261275378641362 1 1.90677 1.62811 2.28482 1.88801 GeneID:2120,Genbank:XM_017018990.1,HGNC:HGNC:3495,MIM:600618 ETS variant 6 hsa05202 Transcriptional misregulation in cancer ETV7 9.61217933864672 7.10113100082778 12.1232276764657 1.70722490192794 0.771653124870299 0.611906712295663 1 0.0515727 0.107874 0.241317 0.0449351 GeneID:51513,Genbank:NM_001207039.1,HGNC:HGNC:18160,MIM:605255 ETS variant 7 GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0005654,GO:0006366,GO:0009887,GO:0030154 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|nucleoplasm|transcription from RNA polymerase II promoter|animal organ morphogenesis|cell differentiation hsa05202 Transcriptional misregulation in cancer EVA1A 1297.81387222693 1358.44370955019 1237.18403490368 0.91073632731778 -0.134894663616973 0.355100940162409 1 23.7918 24.5194 21.0084 22.9853 GeneID:84141,Genbank:NM_032181.2,HGNC:HGNC:25816 eva-1 homolog A, regulator of programmed cell death GO:0005765,GO:0005788,GO:0005789,GO:0005886,GO:0006914,GO:0006915,GO:0016021,GO:0043231,GO:0043687,GO:0044267 lysosomal membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|plasma membrane|autophagy|apoptotic process|integral component of membrane|intracellular membrane-bounded organelle|post-translational protein modification|cellular protein metabolic process EVA1B 300.884102970979 291.116945068615 310.651260873342 1.06710126681263 0.0936970929345367 0.677900420943503 1 8.50531 10.78 11.368 9.71914 GeneID:55194,Genbank:NM_018166.2,HGNC:HGNC:25558 eva-1 homolog B GO:0016021 integral component of membrane EVA1C 237.467572775109 219.499893798794 255.435251751424 1.16371469402883 0.218737398484662 0.347152209933903 1 2.27073 2.38448 3.13832 2.24776 GeneID:59271,Genbank:NM_001320745.1,HGNC:HGNC:13239 eva-1 homolog C GO:0008201,GO:0016021,GO:0030246 heparin binding|integral component of membrane|carbohydrate binding EVC 563.491508315232 608.887816939958 518.095199690506 0.850887774851955 -0.232959230122025 0.172508085880094 1 2.11043 2.03492 1.93973 1.61334 GeneID:2121,Genbank:NM_153717.2,HGNC:HGNC:3497,MIM:604831 EvC ciliary complex subunit 1 GO:0001501,GO:0003416,GO:0005737,GO:0005929,GO:0007224,GO:0007517,GO:0016021,GO:0036064,GO:0045880,GO:0051216,GO:0060170,GO:0098797 skeletal system development|endochondral bone growth|cytoplasm|cilium|smoothened signaling pathway|muscle organ development|integral component of membrane|ciliary basal body|positive regulation of smoothened signaling pathway|cartilage development|ciliary membrane|plasma membrane protein complex hsa04340 Hedgehog signaling pathway EVC2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00579208 GeneID:132884,Genbank:NM_001166136.1,HGNC:HGNC:19747,MIM:607261 EvC ciliary complex subunit 2 GO:0005634,GO:0005737,GO:0005856,GO:0005929,GO:0007224,GO:0016021,GO:0060170,GO:0098797 nucleus|cytoplasm|cytoskeleton|cilium|smoothened signaling pathway|integral component of membrane|ciliary membrane|plasma membrane protein complex hsa04340 Hedgehog signaling pathway EVI2A 73.6872424440295 76.6128008379097 70.7616840501492 0.923627426177256 -0.11461708177701 0.783197560219092 1 0.997958 0.705378 0.898522 0.743711 GeneID:2123,Genbank:NM_014210.3,HGNC:HGNC:3499,MIM:158380 ecotropic viral integration site 2A GO:0004888,GO:0016021 transmembrane signaling receptor activity|integral component of membrane EVI2B 63.9625005475993 68.7814670616998 59.1435340334989 0.859876018353093 -0.21779943577216 0.717147659956988 1 1.04856 0.665973 1.12601 0.511969 GeneID:2124,Genbank:XM_005257946.4,HGNC:HGNC:3500,MIM:158381 ecotropic viral integration site 2B GO:0005887,GO:0030854,GO:0043066,GO:0045660,GO:0061515,GO:0071157,GO:2000035 integral component of plasma membrane|positive regulation of granulocyte differentiation|negative regulation of apoptotic process|positive regulation of neutrophil differentiation|myeloid cell development|negative regulation of cell cycle arrest|regulation of stem cell division EVI5 167.561938394988 186.320134290603 148.803742499373 0.798645530532326 -0.324372772978045 0.219061554173093 1 0.590652 0.733538 0.669762 0.410178 GeneID:7813,Genbank:NM_005665.5,HGNC:HGNC:3501,MIM:602942 ecotropic viral integration site 5 GO:0005096,GO:0005634,GO:0005794,GO:0005815,GO:0005819,GO:0005829,GO:0006886,GO:0007049,GO:0007275,GO:0008283,GO:0012505,GO:0017137,GO:0031338,GO:0042147,GO:0043231,GO:0043547,GO:0051301,GO:0090630 GTPase activator activity|nucleus|Golgi apparatus|microtubule organizing center|spindle|cytosol|intracellular protein transport|cell cycle|multicellular organism development|cell proliferation|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|positive regulation of GTPase activity|cell division|activation of GTPase activity EVI5L 636.642807958018 504.669355459875 768.61626045616 1.52300957476557 0.606925011702677 0.000311261714459 0.0465903515773397 4.67728 5.58342 8.12078 7.96959 GeneID:115704,Genbank:XM_005272458.5,HGNC:HGNC:30464 ecotropic viral integration site 5 like GO:0005096,GO:0005622,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0043547,GO:0090630,GO:1902018 GTPase activator activity|intracellular|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|positive regulation of GTPase activity|activation of GTPase activity|negative regulation of cilium assembly EVL 510.871439147166 482.376010998369 539.366867295962 1.11814612459612 0.161108738677118 0.376910458698653 1 1.9863 2.44556 2.45635 2.66928 GeneID:51466,Genbank:NM_001330221.1,HGNC:HGNC:20234,MIM:616912 Enah/Vasp-like GO:0003779,GO:0005522,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0007015,GO:0007166,GO:0007399,GO:0007411,GO:0008154,GO:0009887,GO:0010633,GO:0016020,GO:0017124,GO:0030027,GO:0045010,GO:0045335,GO:0051289,GO:0051496,GO:0071346,GO:1900028 actin binding|profilin binding|cytoplasm|cytosol|cytoskeleton|focal adhesion|actin filament organization|cell surface receptor signaling pathway|nervous system development|axon guidance|actin polymerization or depolymerization|animal organ morphogenesis|negative regulation of epithelial cell migration|membrane|SH3 domain binding|lamellipodium|actin nucleation|phagocytic vesicle|protein homotetramerization|positive regulation of stress fiber assembly|cellular response to interferon-gamma|negative regulation of ruffle assembly EVPL 1.04924568023034 1.61429302992691 0.484198330533773 0.299944509179783 -1.73723247328634 0.787670862996782 1 0.0198445 0 0 0 GeneID:2125,Genbank:NM_001988.3,HGNC:HGNC:3503,MIM:601590 envoplakin GO:0001533,GO:0005198,GO:0005829,GO:0008544,GO:0018149,GO:0019215,GO:0030057,GO:0030216,GO:0030674,GO:0045111,GO:0045296,GO:0070062,GO:0070268 cornified envelope|structural molecule activity|cytosol|epidermis development|peptide cross-linking|intermediate filament binding|desmosome|keratinocyte differentiation|protein binding, bridging|intermediate filament cytoskeleton|cadherin binding|extracellular exosome|cornification EVX1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0167333 GeneID:2128,Genbank:NM_001989.4,HGNC:HGNC:3506,MIM:142996 even-skipped homeobox 1 GO:0003700,GO:0005654,GO:0009792,GO:0021913,GO:0043565,GO:0045944 DNA binding transcription factor activity|nucleoplasm|embryo development ending in birth or egg hatching|regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter EVX2 1.34524419160576 2.69048838321152 0 0 -Inf 0.430770198131168 1 0 0 0 0 GeneID:344191,Genbank:NM_001080458.1,HGNC:HGNC:3507,MIM:142991 even-skipped homeobox 2 GO:0005634,GO:0006355,GO:0035108,GO:0043565 nucleus|regulation of transcription, DNA-templated|limb morphogenesis|sequence-specific DNA binding EWSR1 6635.48402779867 6883.30992558179 6387.65813001555 0.927992230347765 -0.107815368506145 0.41211250341577 1 28.7588 29.5386 27.2922 28.0366 GeneID:2130,Genbank:NM_013986.3,HGNC:HGNC:3508,MIM:133450 EWS RNA binding protein 1 GO:0003723,GO:0005516,GO:0005634,GO:0005730,GO:0005737,GO:0005886,GO:0006351,GO:0006355,GO:0042802,GO:0046872 RNA binding|calmodulin binding|nucleus|nucleolus|cytoplasm|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|identical protein binding|metal ion binding hsa05202 Transcriptional misregulation in cancer EXD1 1.48128460876238 0.538097676642304 2.42447154088245 4.50563465728193 2.17173033632162 0.550892730611028 1 0.0108151 0 0.0311097 0.0096721 GeneID:161829,Genbank:NM_152596.3,HGNC:HGNC:28507 exonuclease 3'-5' domain containing 1 GO:0003723,GO:0031047,GO:0034587,GO:0042803,GO:0043186,GO:0051321,GO:1990923 RNA binding|gene silencing by RNA|piRNA metabolic process|protein homodimerization activity|P granule|meiotic cell cycle|PET complex EXD2 797.045362888961 737.27468159597 856.816044181952 1.1621395194627 0.216783280406798 0.171095954024139 1 5.36349 5.49524 6.3951 6.13598 GeneID:55218,Genbank:NM_001193360.1,HGNC:HGNC:20217,MIM:616940 exonuclease 3'-5' domain containing 2 GO:0000724,GO:0000729,GO:0003676,GO:0005634,GO:0005737,GO:0006302,GO:0008310,GO:0008408,GO:0008852,GO:0090305 double-strand break repair via homologous recombination|DNA double-strand break processing|nucleic acid binding|nucleus|cytoplasm|double-strand break repair|single-stranded DNA 3'-5' exodeoxyribonuclease activity|3'-5' exonuclease activity|exodeoxyribonuclease I activity|nucleic acid phosphodiester bond hydrolysis EXD3 33.4448241096356 34.4196509957464 32.4699972235249 0.943356375912632 -0.0841252077252615 0.898566424067969 1 0.142663 0.0437124 0.0564262 0.0880373 GeneID:54932,Genbank:NM_017820.4,HGNC:HGNC:26023 exonuclease 3'-5' domain containing 3 GO:0003676,GO:0005634,GO:0005737,GO:0008408,GO:0046872 nucleic acid binding|nucleus|cytoplasm|3'-5' exonuclease activity|metal ion binding EXO1 668.370413999506 669.357687478599 667.383140520412 0.997050086978721 -0.00426211441556552 0.988837109684211 1 5.27191 5.35903 5.84522 4.92596 GeneID:9156,Genbank:XM_011544322.1,HGNC:HGNC:3511,MIM:606063 exonuclease 1 hsa03430 Mismatch repair EXO5 122.604172033023 112.906493547224 132.301850518822 1.17178247558885 0.228704779217812 0.408029729592668 1 1.33002 1.418 1.65788 1.61329 GeneID:64789,Genbank:NM_001346946.1,HGNC:HGNC:26115 exonuclease 5 GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0008310,GO:0036297,GO:0042803,GO:0045145,GO:0046872,GO:0051539 DNA binding|nucleus|nucleoplasm|cytosol|single-stranded DNA 3'-5' exodeoxyribonuclease activity|interstrand cross-link repair|protein homodimerization activity|single-stranded DNA 5'-3' exodeoxyribonuclease activity|metal ion binding|4 iron, 4 sulfur cluster binding EXOC1 681.550540610443 688.441046189612 674.660035031273 0.979982292987012 -0.0291724130581039 0.873178902524361 1 3.69364 3.82059 4.27058 3.21144 GeneID:55763,Genbank:XM_005265748.1,HGNC:HGNC:30380,MIM:607879 exocyst complex component 1 GO:0000145,GO:0005546,GO:0005737,GO:0005829,GO:0005886,GO:0006887,GO:0006893,GO:0015031,GO:0016020,GO:0016032,GO:0016241,GO:0017049,GO:0048015,GO:0048471,GO:0050714,GO:0051601,GO:0051607,GO:0090543,GO:0098592 exocyst|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytosol|plasma membrane|exocytosis|Golgi to plasma membrane transport|protein transport|membrane|viral process|regulation of macroautophagy|GTP-Rho binding|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|positive regulation of protein secretion|exocyst localization|defense response to virus|Flemming body|cytoplasmic side of apical plasma membrane EXOC2 880.237752888998 868.19814715603 892.277358621966 1.02773469575443 0.0394678885415241 0.801682261129994 1 2.31478 2.47508 2.79067 2.20093 GeneID:55770,Genbank:NM_018303.5,HGNC:HGNC:24968,MIM:615329 exocyst complex component 2 GO:0000145,GO:0001927,GO:0005829,GO:0005886,GO:0006893,GO:0015031,GO:0016020,GO:0017160,GO:0019901,GO:0047485,GO:0090543,GO:2000535 exocyst|exocyst assembly|cytosol|plasma membrane|Golgi to plasma membrane transport|protein transport|membrane|Ral GTPase binding|protein kinase binding|protein N-terminus binding|Flemming body|regulation of entry of bacterium into host cell hsa04014 Ras signaling pathway EXOC3 1315.5301647724 1301.30828627588 1329.75204326891 1.02185781593264 0.0311944697400532 0.843759421925309 1 16.459 16.634 16.7509 17.7573 GeneID:11336,Genbank:NM_007277.4,HGNC:HGNC:30378,MIM:608186 exocyst complex component 3 GO:0000145,GO:0000149,GO:0005794,GO:0005829,GO:0006887,GO:0015031,GO:0030426,GO:0030496,GO:0030667,GO:0045296,GO:0048471,GO:0051601 exocyst|SNARE binding|Golgi apparatus|cytosol|exocytosis|protein transport|growth cone|midbody|secretory granule membrane|cadherin binding|perinuclear region of cytoplasm|exocyst localization EXOC3L1 3.74146110135385 2.15239070656922 5.33053149613849 2.47656314435358 1.30833940550066 0.435291872843315 1 0.0238735 0 0 0.0206031 GeneID:283849,Genbank:NM_178516.3,HGNC:HGNC:27540,MIM:614117 exocyst complex component 3 like 1 GO:0000145,GO:0000149,GO:0006887,GO:0030072,GO:0030133,GO:0030141,GO:0051601 exocyst|SNARE binding|exocytosis|peptide hormone secretion|transport vesicle|secretory granule|exocyst localization EXOC3L4 2.0003722474324 2.54640955915669 1.45433493570811 0.571131588191866 -0.808104915392946 0.825102646268534 1 0.0183082 0 0.0169528 0.00791308 GeneID:91828,Genbank:XM_011537333.2,HGNC:HGNC:20120 exocyst complex component 3 like 4 GO:0000145,GO:0000149,GO:0006887,GO:0051601 exocyst|SNARE binding|exocytosis|exocyst localization EXOC4 2449.35116136874 2372.39192583884 2526.31039689864 1.0648790233112 0.0906895408899969 0.514053022052921 1 9.73512 10.1045 10.6671 10.8653 GeneID:60412,Genbank:NM_021807.3,HGNC:HGNC:30389,MIM:608185 exocyst complex component 4 GO:0000145,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0006612,GO:0006887,GO:0006893,GO:0006903,GO:0006904,GO:0007268,GO:0016020,GO:0016241,GO:0017160,GO:0030165,GO:0032584,GO:0035748,GO:0045202,GO:0047485,GO:0048341,GO:0090543 exocyst|cytoplasm|cytosol|plasma membrane|microvillus|protein targeting to membrane|exocytosis|Golgi to plasma membrane transport|vesicle targeting|vesicle docking involved in exocytosis|chemical synaptic transmission|membrane|regulation of macroautophagy|Ral GTPase binding|PDZ domain binding|growth cone membrane|myelin sheath abaxonal region|synapse|protein N-terminus binding|paraxial mesoderm formation|Flemming body EXOC5 346.611596818905 336.950283131726 356.272910506085 1.05734563329275 0.080447053095546 0.826047371636238 1 1.91537 1.35754 2.17863 1.32771 GeneID:10640,Genbank:NM_006544.3,HGNC:HGNC:10696,MIM:604469 exocyst complex component 5 GO:0000145,GO:0005737,GO:0005829,GO:0006887,GO:0006892,GO:0006893,GO:0015031,GO:0017160,GO:0030496,GO:0047485,GO:0048278 exocyst|cytoplasm|cytosol|exocytosis|post-Golgi vesicle-mediated transport|Golgi to plasma membrane transport|protein transport|Ral GTPase binding|midbody|protein N-terminus binding|vesicle docking EXOC6 319.340765091488 332.867032782651 305.814497400325 0.918728703301806 -0.122289192224579 0.560257539005814 1 2.0718 1.79596 1.97547 1.61515 GeneID:54536,Genbank:NM_001013848.3,HGNC:HGNC:23196,MIM:609672 exocyst complex component 6 GO:0000145,GO:0005829,GO:0005886,GO:0006904,GO:0015031,GO:0030426,GO:0048471,GO:0090543 exocyst|cytosol|plasma membrane|vesicle docking involved in exocytosis|protein transport|growth cone|perinuclear region of cytoplasm|Flemming body EXOC6B 401.045382078534 414.842210077623 387.248554079445 0.93348397215169 -0.0993028431865913 0.605769924766144 1 1.50949 1.44478 1.49298 1.25047 GeneID:23233,Genbank:NM_001321734.1,HGNC:HGNC:17085,MIM:607880 exocyst complex component 6B GO:0000145,GO:0006904,GO:0015031 exocyst|vesicle docking involved in exocytosis|protein transport EXOC7 4400.23120159729 4012.00809059529 4788.45431259928 1.1935305723396 0.255235521591723 0.0581813077425399 0.875517516166731 16.0998 16.4892 19.894 20.3828 GeneID:23265,Genbank:NM_015219.4,HGNC:HGNC:23214,MIM:608163 exocyst complex component 7 GO:0000145,GO:0005815,GO:0005829,GO:0005886,GO:0006887,GO:0015031,GO:0016020,GO:0016241,GO:0032584,GO:0034451,GO:0090543,GO:2000535 exocyst|microtubule organizing center|cytosol|plasma membrane|exocytosis|protein transport|membrane|regulation of macroautophagy|growth cone membrane|centriolar satellite|Flemming body|regulation of entry of bacterium into host cell hsa04910 Insulin signaling pathway EXOC8 375.433776982865 405.780793468966 345.086760496764 0.850426550617795 -0.233741455865617 0.220915592229782 1 3.73533 3.47992 3.47593 2.71539 GeneID:149371,Genbank:NM_175876.4,HGNC:HGNC:24659,MIM:615283 exocyst complex component 8 GO:0000145,GO:0001927,GO:0005770,GO:0005829,GO:0005886,GO:0007032,GO:0015031,GO:0016020,GO:0016241,GO:0017160,GO:0022617,GO:0030426,GO:0031252,GO:0048471,GO:0051601 exocyst|exocyst assembly|late endosome|cytosol|plasma membrane|endosome organization|protein transport|membrane|regulation of macroautophagy|Ral GTPase binding|extracellular matrix disassembly|growth cone|cell leading edge|perinuclear region of cytoplasm|exocyst localization EXOG 436.878493057495 445.793143640091 427.963842474899 0.960005438801485 -0.0588855156059605 0.756409330480653 1 2.00729 1.98691 2.17214 1.75494 GeneID:9941,Genbank:XM_017007589.1,HGNC:HGNC:3347,MIM:604051 exo/endonuclease G GO:0003676,GO:0004519,GO:0005743,GO:0008409,GO:0043234,GO:0046872 nucleic acid binding|endonuclease activity|mitochondrial inner membrane|5'-3' exonuclease activity|protein complex|metal ion binding EXOSC1 784.248147443499 848.365985360273 720.130309526725 0.848843921083079 -0.236428788435104 0.131008974905785 1 3.98351 4.73679 3.91382 4.13858 GeneID:51013,Genbank:NM_001318364.1,HGNC:HGNC:17286,MIM:606493 exosome component 1 GO:0000176,GO:0000178,GO:0003723,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0043488,GO:0043928 nuclear exosome (RNase complex)|exosome (RNase complex)|RNA binding|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|regulation of mRNA stability|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay hsa03018 RNA degradation EXOSC10 2241.96033196806 2414.01653503818 2069.90412889794 0.857452340882661 -0.221871609587979 0.115149613566081 1 22.374 21.2758 19.8587 17.4312 GeneID:5394,Genbank:NM_002685.3,HGNC:HGNC:9138,MIM:605960 exosome component 10 GO:0000166,GO:0000175,GO:0000176,GO:0000178,GO:0000184,GO:0000460,GO:0000956,GO:0003723,GO:0004532,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0009048,GO:0016020,GO:0032211,GO:0035327,GO:0070034,GO:0071028,GO:0071034,GO:0071035,GO:0071044,GO:0071048,GO:1904872 nucleotide binding|3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|exosome (RNase complex)|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of 5.8S rRNA|nuclear-transcribed mRNA catabolic process|RNA binding|exoribonuclease activity|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|dosage compensation by inactivation of X chromosome|membrane|negative regulation of telomere maintenance via telomerase|transcriptionally active chromatin|telomerase RNA binding|nuclear mRNA surveillance|CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|histone mRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|regulation of telomerase RNA localization to Cajal body hsa03018 RNA degradation EXOSC2 800.721794727524 866.737741605266 734.705847849782 0.847667999883159 -0.238428769613339 0.13177635424263 1 9.65306 10.3957 8.60531 8.14975 GeneID:23404,Genbank:NM_014285.6,HGNC:HGNC:17097,MIM:602238 exosome component 2 GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0008312,GO:0030307,GO:0034427,GO:0034475,GO:0043488,GO:0043928,GO:0071034,GO:0071035,GO:0071038,GO:0071049,GO:0071051 3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|7S RNA binding|positive regulation of cell growth|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|regulation of mRNA stability|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing hsa03018 RNA degradation EXOSC3 414.136584959875 446.389076246526 381.884093673224 0.855496054886259 -0.225166893134864 0.21942542668067 1 9.94451 9.88958 8.77359 8.46969 GeneID:51010,Genbank:NM_001002269.2,HGNC:HGNC:17944,MIM:606489 exosome component 3 GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0034427,GO:0034475,GO:0035327,GO:0043488,GO:0043928,GO:0045006,GO:0045190,GO:0045830,GO:0071034,GO:0071035,GO:0071038,GO:0071049,GO:0071051 3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|transcriptionally active chromatin|regulation of mRNA stability|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|DNA deamination|isotype switching|positive regulation of isotype switching|CUT catabolic process|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription|polyadenylation-dependent snoRNA 3'-end processing hsa03018 RNA degradation EXOSC4 563.061230949145 588.210799510089 537.911662388201 0.914487906097982 -0.128964004112755 0.541135682700943 1 29.8097 37.3798 30.1883 32.8719 GeneID:54512,Genbank:XM_011517134.3,HGNC:HGNC:18189,MIM:606491 exosome component 4 GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000460,GO:0000956,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0016075,GO:0017091,GO:0030307,GO:0031125,GO:0034427,GO:0034475,GO:0035327,GO:0043488,GO:0043928,GO:0045006,GO:0045111,GO:0051607,GO:0071028,GO:0071044,GO:0071051 3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|maturation of 5.8S rRNA|nuclear-transcribed mRNA catabolic process|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|rRNA catabolic process|AU-rich element binding|positive regulation of cell growth|rRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|transcriptionally active chromatin|regulation of mRNA stability|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|DNA deamination|intermediate filament cytoskeleton|defense response to virus|nuclear mRNA surveillance|histone mRNA catabolic process|polyadenylation-dependent snoRNA 3'-end processing hsa03018 RNA degradation EXOSC5 536.949351049095 594.638545664472 479.260156433716 0.805968869539347 -0.311203978998324 0.0655653378362618 0.903695740779319 29.1123 31.3361 22.3854 26.8708 GeneID:56915,Genbank:NM_020158.3,HGNC:HGNC:24662,MIM:606492 exosome component 5 GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0016075,GO:0031125,GO:0034427,GO:0034475,GO:0035327,GO:0043488,GO:0043928,GO:0045006,GO:0051607,GO:0071028,GO:0071051 3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|rRNA catabolic process|rRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|transcriptionally active chromatin|regulation of mRNA stability|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|DNA deamination|defense response to virus|nuclear mRNA surveillance|polyadenylation-dependent snoRNA 3'-end processing hsa03018 RNA degradation EXOSC6 791.721887792609 871.071948983728 712.37182660149 0.817810546456706 -0.290161426957445 0.065143314871874 0.901277047586747 36.6987 37.2092 30.4777 31.5996 GeneID:118460,Genbank:NM_058219.2,HGNC:HGNC:19055,MIM:606490 exosome component 6 GO:0000176,GO:0000177,GO:0000178,GO:0003723,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0016075,GO:0031125,GO:0034427,GO:0034475,GO:0043488,GO:0043928,GO:0045006,GO:0045190,GO:0045830,GO:0071028,GO:0071051 nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|RNA binding|nucleoplasm|nucleolus|cytosol|rRNA processing|rRNA catabolic process|rRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U4 snRNA 3'-end processing|regulation of mRNA stability|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|DNA deamination|isotype switching|positive regulation of isotype switching|nuclear mRNA surveillance|polyadenylation-dependent snoRNA 3'-end processing hsa03018 RNA degradation EXOSC7 878.361528521557 946.022430517026 810.700626526089 0.856957087246885 -0.222705132750496 0.185587251087543 1 16.4379 17.2887 13.403 16.1957 GeneID:23016,Genbank:XM_017005930.2,HGNC:HGNC:28112,MIM:606488 exosome component 7 GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0003723,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0006401,GO:0017091,GO:0034427,GO:0034473,GO:0034475,GO:0034476,GO:0043488,GO:0043928,GO:0071028,GO:0071035,GO:0071038,GO:0071042 3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|nucleolus|cytosol|rRNA processing|RNA catabolic process|AU-rich element binding|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U1 snRNA 3'-end processing|U4 snRNA 3'-end processing|U5 snRNA 3'-end processing|regulation of mRNA stability|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process hsa03018 RNA degradation EXOSC8 569.466543905068 632.016208380469 506.916879429666 0.802063100135725 -0.318212353628788 0.0643784759104959 0.90091963811897 14.7016 13.1495 11.7267 11.0415 GeneID:11340,Genbank:XM_006719763.1,HGNC:HGNC:17035,MIM:606019 exosome component 8 GO:0000176,GO:0000177,GO:0000178,GO:0000467,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0017091,GO:0034427,GO:0034473,GO:0034475,GO:0034476,GO:0042802,GO:0043488,GO:0043928,GO:0071028,GO:0071035,GO:0071038,GO:0071042 nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|AU-rich element binding|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U1 snRNA 3'-end processing|U4 snRNA 3'-end processing|U5 snRNA 3'-end processing|identical protein binding|regulation of mRNA stability|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process hsa03018 RNA degradation EXOSC9 582.520013092868 595.598054157316 569.44197202842 0.956084339184246 -0.0647902064344681 0.722204906805276 1 8.82441 8.07862 8.78176 7.91979 GeneID:5393,Genbank:NM_001034194.1,HGNC:HGNC:9137,MIM:606180 exosome component 9 GO:0000175,GO:0000176,GO:0000177,GO:0000178,GO:0000228,GO:0000467,GO:0000956,GO:0001102,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006955,GO:0017091,GO:0030307,GO:0034427,GO:0034473,GO:0034475,GO:0034476,GO:0043488,GO:0043928,GO:0045944,GO:0070062,GO:0071028,GO:0071035,GO:0071038,GO:0071042 3'-5'-exoribonuclease activity|nuclear exosome (RNase complex)|cytoplasmic exosome (RNase complex)|exosome (RNase complex)|nuclear chromosome|exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nuclear-transcribed mRNA catabolic process|RNA polymerase II activating transcription factor binding|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|immune response|AU-rich element binding|positive regulation of cell growth|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|U1 snRNA 3'-end processing|U4 snRNA 3'-end processing|U5 snRNA 3'-end processing|regulation of mRNA stability|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|positive regulation of transcription from RNA polymerase II promoter|extracellular exosome|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|nuclear polyadenylation-dependent tRNA catabolic process|nuclear polyadenylation-dependent mRNA catabolic process hsa03018 RNA degradation EXPH5 19.8359235168395 21.7356294746478 17.9362175590311 0.825198901184422 -0.277186194720696 0.708297140864984 1 0.054308 0.0441262 0.0548231 0.026785 GeneID:23086,Genbank:XM_017017398.1,HGNC:HGNC:30578,MIM:612878 exophilin 5 GO:0003334,GO:0005768,GO:0006886,GO:0017137,GO:0045921,GO:0050714,GO:0071985 keratinocyte development|endosome|intracellular protein transport|Rab GTPase binding|positive regulation of exocytosis|positive regulation of protein secretion|multivesicular body sorting pathway EXT1 725.733257982516 712.858372393218 738.608143571814 1.03612186119404 0.0511936924079056 0.761370393415177 1 7.59633 7.93083 8.74872 7.53985 GeneID:2131,Genbank:NM_000127.2,HGNC:HGNC:3512,MIM:608177 exostosin glycosyltransferase 1 hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EXT2 3304.09171064923 3275.40577684491 3332.77764445356 1.01751595726375 0.0250514198328071 0.868779614737075 1 23.6352 25.3678 25.8266 25.3547 GeneID:2132,Genbank:NM_001178083.1,HGNC:HGNC:3513,MIM:608210 exostosin glycosyltransferase 2 hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EXTL1 3.18141685102747 1.51824048055703 4.84459322149792 3.1909261303061 1.67397521072484 0.39830721956274 1 0.0112117 0.019488 0.0103866 0.0582636 GeneID:2134,Genbank:XM_005245779.4,HGNC:HGNC:3515,MIM:601738 exostosin like glycosyltransferase 1 hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EXTL2 488.368850346412 491.10901833763 485.628682355194 0.988840897279821 -0.0161896822653876 0.956327873788262 1 5.72582 5.16033 5.70808 4.83545 GeneID:2135,Genbank:NM_001261440.1,HGNC:HGNC:3516,MIM:602411 exostosin like glycosyltransferase 2 hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EXTL3 5289.59793387809 3835.89219485067 6743.3036729055 1.75794921503731 0.81389339342096 1.12032320104224e-09 2.24288704848657e-06 26.9886 27.4651 51.3175 46.3317 GeneID:2137,Genbank:XM_024447096.1,HGNC:HGNC:3518,MIM:605744 exostosin like glycosyltransferase 3 hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin EYA1 4.53340408611022 5.18887166768327 3.87793650453717 0.747356410583303 -0.420131673621451 0.850376712759141 1 0.0162832 0.00785334 0.0117769 0.0109702 GeneID:2138,Genbank:XM_017013201.1,HGNC:HGNC:3519,MIM:601653 EYA transcriptional coactivator and phosphatase 1 GO:0001656,GO:0001658,GO:0003151,GO:0003723,GO:0004725,GO:0005634,GO:0005654,GO:0005737,GO:0006302,GO:0006351,GO:0007389,GO:0007501,GO:0007605,GO:0009653,GO:0010212,GO:0014706,GO:0016576,GO:0016604,GO:0016925,GO:0030154,GO:0032993,GO:0035909,GO:0042473,GO:0042474,GO:0043234,GO:0045664,GO:0045739,GO:0045944,GO:0046872,GO:0048665,GO:0048704,GO:0048752,GO:0050679,GO:0060037,GO:0071600,GO:0072513,GO:0090103,GO:2001240 metanephros development|branching involved in ureteric bud morphogenesis|outflow tract morphogenesis|RNA binding|protein tyrosine phosphatase activity|nucleus|nucleoplasm|cytoplasm|double-strand break repair|transcription, DNA-templated|pattern specification process|mesodermal cell fate specification|sensory perception of sound|anatomical structure morphogenesis|response to ionizing radiation|striated muscle tissue development|histone dephosphorylation|nuclear body|protein sumoylation|cell differentiation|protein-DNA complex|aorta morphogenesis|outer ear morphogenesis|middle ear morphogenesis|protein complex|regulation of neuron differentiation|positive regulation of DNA repair|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|neuron fate specification|embryonic skeletal system morphogenesis|semicircular canal morphogenesis|positive regulation of epithelial cell proliferation|pharyngeal system development|otic vesicle morphogenesis|positive regulation of secondary heart field cardioblast proliferation|cochlea morphogenesis|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa05202 Transcriptional misregulation in cancer EYA2 8.1652406855188 9.06141660865723 7.26906476238037 0.802199598177127 -0.317966851382673 0.785066280123703 1 0.0440872 0.156115 0.0958629 0.102439 GeneID:2139,Genbank:NM_005244.4,HGNC:HGNC:3520,MIM:601654 EYA transcriptional coactivator and phosphatase 2 GO:0000287,GO:0004725,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006281,GO:0006351,GO:0006355,GO:0007501,GO:0008134,GO:0014706,GO:0016576,GO:0045739,GO:0097192,GO:0097345,GO:2001240 magnesium ion binding|protein tyrosine phosphatase activity|nucleus|nucleoplasm|mitochondrion|cytosol|DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|mesodermal cell fate specification|transcription factor binding|striated muscle tissue development|histone dephosphorylation|positive regulation of DNA repair|extrinsic apoptotic signaling pathway in absence of ligand|mitochondrial outer membrane permeabilization|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand EYA3 406.593051638401 377.020468232644 436.165635044157 1.15687521446453 0.210233257546424 0.235744462865316 1 2.16961 1.69412 2.40721 2.17188 GeneID:2140,Genbank:XM_006710449.3,HGNC:HGNC:3521,MIM:601655 EYA transcriptional coactivator and phosphatase 3 GO:0004725,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005813,GO:0006302,GO:0006351,GO:0006355,GO:0007275,GO:0007601,GO:0009653,GO:0010212,GO:0016576,GO:0030154,GO:0045739,GO:0046872,GO:2001240 protein tyrosine phosphatase activity|nucleus|nucleoplasm|transcription factor complex|cytoplasm|centrosome|double-strand break repair|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|visual perception|anatomical structure morphogenesis|response to ionizing radiation|histone dephosphorylation|cell differentiation|positive regulation of DNA repair|metal ion binding|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand EYA4 975.627528859835 1009.98841045256 941.26664726711 0.931957869541636 -0.101663357579894 0.637312813286545 1 4.09555 3.7527 4.1657 3.03205 GeneID:2070,Genbank:XM_017010368.2,HGNC:HGNC:3522,MIM:603550 EYA transcriptional coactivator and phosphatase 4 GO:0004725,GO:0005634,GO:0005737,GO:0006281,GO:0006351,GO:0006355,GO:0007275,GO:0007601,GO:0007605,GO:0009653,GO:0016576,GO:0030154,GO:0045739,GO:0046872,GO:2001240 protein tyrosine phosphatase activity|nucleus|cytoplasm|DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|visual perception|sensory perception of sound|anatomical structure morphogenesis|histone dephosphorylation|cell differentiation|positive regulation of DNA repair|metal ion binding|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand EYS 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0029652 0 0 0 GeneID:346007,Genbank:NM_001142800.1,HGNC:HGNC:21555,MIM:612424 eyes shut homolog (Drosophila) GO:0005509,GO:0043403,GO:0050908,GO:0070062 calcium ion binding|skeletal muscle tissue regeneration|detection of light stimulus involved in visual perception|extracellular exosome EZH1 537.416354663366 510.241420324183 564.591289002549 1.10651794721768 0.146026851185887 0.398079320371299 1 3.41491 3.37265 3.82225 3.7222 GeneID:2145,Genbank:NM_001321079.1,HGNC:HGNC:3526,MIM:601674 enhancer of zeste 1 polycomb repressive complex 2 subunit GO:0003682,GO:0005654,GO:0006351,GO:0009653,GO:0018024,GO:0021766,GO:0035098,GO:0045944,GO:0070734 chromatin binding|nucleoplasm|transcription, DNA-templated|anatomical structure morphogenesis|histone-lysine N-methyltransferase activity|hippocampus development|ESC/E(Z) complex|positive regulation of transcription from RNA polymerase II promoter|histone H3-K27 methylation hsa00310 Lysine degradation EZH2 2218.23900514923 2276.49385253606 2159.98415776239 0.948820553745894 -0.0757928324042731 0.582413857760904 1 8.80754 8.92402 8.7538 8.62578 GeneID:2146,Genbank:NM_001203248.1,HGNC:HGNC:3527,MIM:601573 enhancer of zeste 2 polycomb repressive complex 2 subunit GO:0000122,GO:0000790,GO:0000978,GO:0000979,GO:0001047,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0006306,GO:0006325,GO:0006351,GO:0006355,GO:0010718,GO:0014013,GO:0014834,GO:0014898,GO:0016279,GO:0016571,GO:0018024,GO:0021695,GO:0021766,GO:0031490,GO:0032355,GO:0034244,GO:0035098,GO:0035984,GO:0036333,GO:0042054,GO:0042127,GO:0042752,GO:0043021,GO:0043406,GO:0043433,GO:0043547,GO:0045120,GO:0045605,GO:0045814,GO:0045892,GO:0046976,GO:0048387,GO:0048511,GO:0051154,GO:0070301,GO:0070314,GO:0070317,GO:0070734,GO:0070878,GO:0071168,GO:0071902,GO:0097421,GO:0098532,GO:1900006,GO:1904772,GO:1990841,GO:2000134 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|core promoter binding|DNA binding|chromatin binding|nucleus|nucleoplasm|cytoplasm|DNA methylation|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of epithelial to mesenchymal transition|regulation of gliogenesis|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|cardiac muscle hypertrophy in response to stress|protein-lysine N-methyltransferase activity|histone methylation|histone-lysine N-methyltransferase activity|cerebellar cortex development|hippocampus development|chromatin DNA binding|response to estradiol|negative regulation of transcription elongation from RNA polymerase II promoter|ESC/E(Z) complex|cellular response to trichostatin A|hepatocyte homeostasis|histone methyltransferase activity|regulation of cell proliferation|regulation of circadian rhythm|ribonucleoprotein complex binding|positive regulation of MAP kinase activity|negative regulation of DNA binding transcription factor activity|positive regulation of GTPase activity|pronucleus|negative regulation of epidermal cell differentiation|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K27 specific)|negative regulation of retinoic acid receptor signaling pathway|rhythmic process|negative regulation of striated muscle cell differentiation|cellular response to hydrogen peroxide|G1 to G0 transition|negative regulation of G0 to G1 transition|histone H3-K27 methylation|primary miRNA binding|protein localization to chromatin|positive regulation of protein serine/threonine kinase activity|liver regeneration|histone H3-K27 trimethylation|positive regulation of dendrite development|response to tetrachloromethane|promoter-specific chromatin binding|negative regulation of G1/S transition of mitotic cell cycle hsa00310,hsa05206 Lysine degradation|MicroRNAs in cancer EZR 15295.8613682521 14876.6917398225 15715.0309966818 1.05635253264106 0.0790913803568244 0.546098347906987 1 148.674 153.78 165.076 158.025 GeneID:7430,Genbank:NM_001111077.1,HGNC:HGNC:12691,MIM:123900 ezrin GO:0000122,GO:0001650,GO:0001726,GO:0001772,GO:0001931,GO:0001951,GO:0003376,GO:0003723,GO:0003779,GO:0005615,GO:0005737,GO:0005768,GO:0005829,GO:0005884,GO:0005886,GO:0005902,GO:0005903,GO:0005925,GO:0007016,GO:0007159,GO:0007411,GO:0008017,GO:0008022,GO:0008360,GO:0010628,GO:0010737,GO:0015629,GO:0016020,GO:0016323,GO:0016324,GO:0019898,GO:0019904,GO:0022614,GO:0030033,GO:0030175,GO:0030315,GO:0030863,GO:0030953,GO:0031528,GO:0031532,GO:0031623,GO:0031982,GO:0032532,GO:0032587,GO:0034236,GO:0034237,GO:0034629,GO:0035088,GO:0036064,GO:0040018,GO:0042995,GO:0043209,GO:0043234,GO:0043622,GO:0044297,GO:0044393,GO:0044548,GO:0044853,GO:0045177,GO:0045296,GO:0046847,GO:0048015,GO:0048471,GO:0050714,GO:0050839,GO:0050860,GO:0051015,GO:0051017,GO:0051018,GO:0051117,GO:0051286,GO:0051660,GO:0061028,GO:0070062,GO:0070373,GO:0071320,GO:0071437,GO:0071944,GO:0072659,GO:0072697,GO:0097449,GO:0097454,GO:0097718,GO:0098592,GO:1900041,GO:1902115,GO:1902896,GO:1902966,GO:1903078,GO:1903364,GO:1903753,GO:2000643 negative regulation of transcription from RNA polymerase II promoter|fibrillar center|ruffle|immunological synapse|uropod|intestinal D-glucose absorption|sphingosine-1-phosphate signaling pathway|RNA binding|actin binding|extracellular space|cytoplasm|endosome|cytosol|actin filament|plasma membrane|microvillus|brush border|focal adhesion|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|axon guidance|microtubule binding|protein C-terminus binding|regulation of cell shape|positive regulation of gene expression|protein kinase A signaling|actin cytoskeleton|membrane|basolateral plasma membrane|apical plasma membrane|extrinsic component of membrane|protein domain specific binding|membrane to membrane docking|microvillus assembly|filopodium|T-tubule|cortical cytoskeleton|astral microtubule organization|microvillus membrane|actin cytoskeleton reorganization|receptor internalization|vesicle|regulation of microvillus length|ruffle membrane|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|cellular protein complex localization|establishment or maintenance of apical/basal cell polarity|ciliary basal body|positive regulation of multicellular organism growth|cell projection|myelin sheath|protein complex|cortical microtubule organization|cell body|microspike|S100 protein binding|plasma membrane raft|apical part of cell|cadherin binding|filopodium assembly|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|positive regulation of protein secretion|cell adhesion molecule binding|negative regulation of T cell receptor signaling pathway|actin filament binding|actin filament bundle assembly|protein kinase A binding|ATPase binding|cell tip|establishment of centrosome localization|establishment of endothelial barrier|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|cellular response to cAMP|invadopodium|cell periphery|protein localization to plasma membrane|protein localization to cell cortex|astrocyte projection|Schwann cell microvillus|disordered domain specific binding|cytoplasmic side of apical plasma membrane|negative regulation of interleukin-2 secretion|regulation of organelle assembly|terminal web assembly|positive regulation of protein localization to early endosome|positive regulation of protein localization to plasma membrane|positive regulation of cellular protein catabolic process|negative regulation of p38MAPK cascade|positive regulation of early endosome to late endosome transport hsa04530,hsa04670,hsa04810,hsa04971,hsa05130,hsa05205,hsa05206 Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Gastric acid secretion|Pathogenic Escherichia coli infection|Proteoglycans in cancer|MicroRNAs in cancer F10 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0209692 GeneID:2159,Genbank:NM_000504.3,HGNC:HGNC:3528,MIM:613872 coagulation factor X hsa04610 Complement and coagulation cascades F11R 390.082601850764 362.425204379256 417.739999322272 1.152624029109 0.204922001459688 0.273211982062447 1 3.08054 3.17279 3.67652 3.61158 GeneID:50848,Genbank:NM_001348091.1,HGNC:HGNC:14685,MIM:605721 F11 receptor GO:0001618,GO:0001817,GO:0005886,GO:0005911,GO:0005923,GO:0006954,GO:0007155,GO:0007179,GO:0009314,GO:0016021,GO:0030054,GO:0030165,GO:0030198,GO:0031032,GO:0031410,GO:0034260,GO:0036057,GO:0043547,GO:0045296,GO:0045777,GO:0050892,GO:0050900,GO:0070062,GO:0070830,GO:0072659,GO:0090557,GO:0090559,GO:2000249 virus receptor activity|regulation of cytokine production|plasma membrane|cell-cell junction|bicellular tight junction|inflammatory response|cell adhesion|transforming growth factor beta receptor signaling pathway|response to radiation|integral component of membrane|cell junction|PDZ domain binding|extracellular matrix organization|actomyosin structure organization|cytoplasmic vesicle|negative regulation of GTPase activity|slit diaphragm|positive regulation of GTPase activity|cadherin binding|positive regulation of blood pressure|intestinal absorption|leukocyte migration|extracellular exosome|bicellular tight junction assembly|protein localization to plasma membrane|establishment of endothelial intestinal barrier|regulation of membrane permeability|regulation of actin cytoskeleton reorganization hsa04514,hsa04530,hsa04670,hsa05120 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Epithelial cell signaling in Helicobacter pylori infection F12 113.851427062057 134.17166893013 93.5311851939841 0.697100855492009 -0.520560696767794 0.0610763956154545 0.882851581387291 1.48053 2.17698 1.37321 1.45813 GeneID:2161,Genbank:NM_000505.3,HGNC:HGNC:3530,MIM:610619 coagulation factor XII hsa04610 Complement and coagulation cascades F13A1 1.21517230615302 0.490071401957362 1.94027321034868 3.95916432299286 1.98519594689495 0.683429885754535 1 0 0.00848506 0.0348632 0 GeneID:2162,Genbank:NM_000129.3,HGNC:HGNC:3531,MIM:134570 coagulation factor XIII A chain hsa04610 Complement and coagulation cascades F13B 0.780631827935889 1.07619535328461 0.48506830258717 0.450725141217823 -1.14968016979823 0.981241458110389 1 0.0211289 0 0.0102864 0 GeneID:2165,Genbank:XM_011509284.2,HGNC:HGNC:3534,MIM:134580 coagulation factor XIII B chain hsa04610 Complement and coagulation cascades F2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0205069 0 0 0 GeneID:2147,Genbank:NM_000506.4,HGNC:HGNC:3535,MIM:176930 coagulation factor II, thrombin hsa04080,hsa04610,hsa04810 Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Regulation of actin cytoskeleton F2R 4519.7983250914 4042.52170268132 4997.07494750148 1.23612816826364 0.305828337200155 0.0986798513581175 1 48.0679 46.2795 68.191 50.7798 GeneID:2149,Genbank:NM_001311313.1,HGNC:HGNC:3537,MIM:187930 coagulation factor II thrombin receptor hsa04015,hsa04020,hsa04024,hsa04072,hsa04080,hsa04151,hsa04610,hsa04611,hsa04810,hsa05200 Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Complement and coagulation cascades|Platelet activation|Regulation of actin cytoskeleton|Pathways in cancer F2RL1 1.50986585944834 1.56626675524197 1.45346496365472 0.927980472541008 -0.107833647793846 1 1 0.0314208 0.0148236 0.015073 0.0280881 GeneID:2150,Genbank:NM_005242.5,HGNC:HGNC:3538,MIM:600933 F2R like trypsin receptor 1 hsa04080,hsa04750,hsa05143 Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels|African trypanosomiasis F2RL2 15.6170800878554 11.8479575412386 19.3862026344723 1.63624848983427 0.710391860644394 0.333862005003081 1 0.152115 0.143267 0.305146 0.257719 GeneID:2151,Genbank:NM_004101.3,HGNC:HGNC:3539,MIM:601919 coagulation factor II thrombin receptor like 2 hsa04080,hsa04610 Neuroactive ligand-receptor interaction|Complement and coagulation cascades F3 189.052618034279 225.428776896968 152.67645917159 0.677271381556449 -0.562194059647924 0.0152874926579417 0.512226950647688 3.45402 3.78297 2.70097 1.98038 GeneID:2152,Genbank:NM_001178096.1,HGNC:HGNC:3541,MIM:134390 coagulation factor III, tissue factor hsa04610,hsa04933 Complement and coagulation cascades|AGE-RAGE signaling pathway in diabetic complications F8 208.821157368462 189.875095618144 227.767219118781 1.1995634202436 0.2625094341234 0.243355833111883 1 0.617744 0.644352 0.765296 0.804434 GeneID:2157,Genbank:NM_000132.3,HGNC:HGNC:3546,MIM:300841 coagulation factor VIII hsa04610 Complement and coagulation cascades F8A1 226.786836639815 218.529559649987 235.044113629642 1.07557125912899 0.105103109871528 0.64879501279189 1 9.59828 10.3212 11.2911 10.6902 GeneID:8263,Genbank:NM_012151.3,HGNC:HGNC:3547,MIM:305423 coagulation factor VIII associated 1 GO:0005634 nucleus F8A2 1.0012194055454 1.51824048055703 0.484198330533773 0.31892070902768 -1.64873031325362 0.791516662337547 1 0 0.838058 0.70988 0.22064 GeneID:474383,Genbank:NM_001007523.1,HGNC:HGNC:31849 coagulation factor VIII associated 2 GO:0005634 nucleus F8A3 2.43110621788434 1.47021420587209 3.3919982298966 2.30714559575662 1.20610905024896 0.657230496217413 1 0 0 0.118313 0.22064 GeneID:474384,Genbank:NM_001007524.1,HGNC:HGNC:31850 coagulation factor VIII associated 3 GO:0005634 nucleus FA2H 30.4066032044148 28.3466890735182 32.4665173353113 1.14533719444652 0.195772399317032 0.718678207893675 1 0.157286 0.23489 0.281379 0.283736 GeneID:79152,Genbank:NM_024306.4,HGNC:HGNC:21197,MIM:611026 fatty acid 2-hydroxylase GO:0001949,GO:0005506,GO:0005783,GO:0005789,GO:0006631,GO:0006633,GO:0016021,GO:0020037,GO:0030148,GO:0030258,GO:0031090,GO:0032286,GO:0032287,GO:0042127,GO:0042634,GO:0080132 sebaceous gland cell differentiation|iron ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|fatty acid biosynthetic process|integral component of membrane|heme binding|sphingolipid biosynthetic process|lipid modification|organelle membrane|central nervous system myelin maintenance|peripheral nervous system myelin maintenance|regulation of cell proliferation|regulation of hair cycle|fatty acid alpha-hydroxylase activity FAAH 18.9128444424805 20.8613478752109 16.96434100975 0.813194866948571 -0.298326986260563 0.661954777365052 1 0.366341 0.363423 0.414767 0.272579 GeneID:2166,Genbank:NM_001441.2,HGNC:HGNC:3553,MIM:602935 fatty acid amide hydrolase hsa04723 Retrograde endocannabinoid signaling FAAH2 0.972203168832738 0.490071401957362 1.45433493570811 2.96759804775273 1.56929569647876 0.837430708298891 1 0 0 0.0132456 0 GeneID:158584,Genbank:XM_011530767.3,HGNC:HGNC:26440,MIM:300654 fatty acid amide hydrolase 2 GO:0005811,GO:0016021,GO:0017064,GO:0019369,GO:0102077,GO:0103073 lipid droplet|integral component of membrane|fatty acid amide hydrolase activity|arachidonic acid metabolic process|oleamide hydrolase activity|anandamide amidohydrolase activity FAAP100 1405.22702539191 1436.98061237806 1373.47343840576 0.955805128179708 -0.0652115867928492 0.62372512294977 1 17.1857 18.7869 18.9164 16.6504 GeneID:80233,Genbank:NM_025161.5,HGNC:HGNC:26171,MIM:611301 Fanconi anemia core complex associated protein 100 GO:0003677,GO:0005654,GO:0005829,GO:0036297,GO:0043240,GO:0045111 DNA binding|nucleoplasm|cytosol|interstrand cross-link repair|Fanconi anaemia nuclear complex|intermediate filament cytoskeleton hsa03460 Fanconi anemia pathway FAAP20 1171.46651745838 1107.66752392209 1235.26551099466 1.1151952046231 0.157296262695102 0.310765859337286 1 3.83257 4.68521 5.19794 5.16586 GeneID:199990,Genbank:XM_017000554.2,HGNC:HGNC:26428,MIM:615183 Fanconi anemia core complex associated protein 20 GO:0005654,GO:0005694,GO:0006974,GO:0016604,GO:0019985,GO:0030054,GO:0031593,GO:0036297,GO:0043130,GO:0043240,GO:0046872,GO:0070530,GO:0140036 nucleoplasm|chromosome|cellular response to DNA damage stimulus|nuclear body|translesion synthesis|cell junction|polyubiquitin modification-dependent protein binding|interstrand cross-link repair|ubiquitin binding|Fanconi anaemia nuclear complex|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|ubiquitin-dependent protein binding FAAP24 258.311780597526 253.94795375901 262.675607436043 1.03436788344952 0.0487493860734169 0.80191987395349 1 6.11564 4.88739 6.11078 5.82929 GeneID:91442,Genbank:XM_005259393.3,HGNC:HGNC:28467,MIM:610884 Fanconi anemia core complex associated protein 24 GO:0003677,GO:0003682,GO:0005654,GO:0036297,GO:0043231,GO:0043240 DNA binding|chromatin binding|nucleoplasm|interstrand cross-link repair|intracellular membrane-bounded organelle|Fanconi anaemia nuclear complex hsa03460 Fanconi anemia pathway FABP3 3.10014575203278 4.74682654041085 1.45346496365472 0.306197193278715 -1.70746703628688 0.403938354723393 1 0.0552179 0 0 0 GeneID:2170,Genbank:XM_011541007.3,HGNC:HGNC:3557,MIM:134651 fatty acid binding protein 3 GO:0005324,GO:0005615,GO:0005829,GO:0006631,GO:0008092,GO:0008285,GO:0016528,GO:0019433,GO:0032868,GO:0036041,GO:0042493,GO:0042632,GO:0044539,GO:0046320,GO:0050543,GO:0055091,GO:0070062,GO:0070538,GO:0070542,GO:0071073,GO:2001245 long-chain fatty acid transporter activity|extracellular space|cytosol|fatty acid metabolic process|cytoskeletal protein binding|negative regulation of cell proliferation|sarcoplasm|triglyceride catabolic process|response to insulin|long-chain fatty acid binding|response to drug|cholesterol homeostasis|long-chain fatty acid import|regulation of fatty acid oxidation|icosatetraenoic acid binding|phospholipid homeostasis|extracellular exosome|oleic acid binding|response to fatty acid|positive regulation of phospholipid biosynthetic process|regulation of phosphatidylcholine biosynthetic process hsa03320 PPAR signaling pathway FABP4 3.48372341985318 3.57457863775636 3.39286820195 0.949165914581637 -0.0752678019271255 1 1 0.0967678 0.1856 0.186994 0.0868737 GeneID:2167,Genbank:NM_001442.2,HGNC:HGNC:3559,MIM:600434 fatty acid binding protein 4 GO:0001816,GO:0005504,GO:0005634,GO:0005737,GO:0005811,GO:0005829,GO:0006469,GO:0019433,GO:0042632,GO:0045892,GO:0050729,GO:0050872,GO:0050873,GO:0070062,GO:0071285,GO:0071356 cytokine production|fatty acid binding|nucleus|cytoplasm|lipid droplet|cytosol|negative regulation of protein kinase activity|triglyceride catabolic process|cholesterol homeostasis|negative regulation of transcription, DNA-templated|positive regulation of inflammatory response|white fat cell differentiation|brown fat cell differentiation|extracellular exosome|cellular response to lithium ion|cellular response to tumor necrosis factor hsa03320,hsa04923 PPAR signaling pathway|Regulation of lipolysis in adipocytes FABP5 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0 0 0.116666 0.0539206 GeneID:2171,Genbank:NM_001444.2,HGNC:HGNC:3560,MIM:605168 fatty acid binding protein 5 GO:0005504,GO:0005576,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0008289,GO:0008544,GO:0019433,GO:0030667,GO:0035578,GO:0043312,GO:0070062 fatty acid binding|extracellular region|nucleoplasm|cytoplasm|cytosol|plasma membrane|lipid metabolic process|lipid binding|epidermis development|triglyceride catabolic process|secretory granule membrane|azurophil granule lumen|neutrophil degranulation|extracellular exosome hsa03320 PPAR signaling pathway FABP6 0.977641254229628 1.47021420587209 0.48506830258717 0.329930360249405 -1.59976655382621 0.793472162274683 1 0 0.0868127 0 0 GeneID:2172,Genbank:NM_001130958.1,HGNC:HGNC:3561,MIM:600422 fatty acid binding protein 6 GO:0005737,GO:0005829,GO:0006629,GO:0008285,GO:0008289,GO:0015721,GO:0016020,GO:0019433,GO:0032052 cytoplasm|cytosol|lipid metabolic process|negative regulation of cell proliferation|lipid binding|bile acid and bile salt transport|membrane|triglyceride catabolic process|bile acid binding hsa03320 PPAR signaling pathway FABP7 2018.46249269946 1749.19598569274 2287.72899970618 1.30787459976943 0.387224220527422 0.0302812147388113 0.688302376485026 12.9421 13.7441 16.4461 18.6149 GeneID:2173,Genbank:NM_001319042.1,HGNC:HGNC:3562,MIM:602965 fatty acid binding protein 7 GO:0005634,GO:0005829,GO:0005911,GO:0007399,GO:0008285,GO:0008289,GO:0019433,GO:0021846,GO:0022008,GO:0042995,GO:0043025,GO:0050673,GO:0060134,GO:0071944 nucleus|cytosol|cell-cell junction|nervous system development|negative regulation of cell proliferation|lipid binding|triglyceride catabolic process|cell proliferation in forebrain|neurogenesis|cell projection|neuronal cell body|epithelial cell proliferation|prepulse inhibition|cell periphery hsa03320 PPAR signaling pathway FADD 1005.65604724347 982.008348268014 1029.30374621892 1.04816191026718 0.0678615881515238 0.664335564622946 1 24.2839 23.9263 24.6265 26.2846 GeneID:8772,Genbank:NM_003824.3,HGNC:HGNC:3573,MIM:602457 Fas associated via death domain hsa01524,hsa04210,hsa04215,hsa04217,hsa04620,hsa04621,hsa04622,hsa04657,hsa04668,hsa05010,hsa05142,hsa05152,hsa05161,hsa05163,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200 Platinum drug resistance|Apoptosis|Apoptosis - multiple species|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Alzheimer disease|Chagas disease (American trypanosomiasis)|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer FADS1 5220.63671426476 5393.07827752721 5048.19515100231 0.936050784213161 -0.0953412914195293 0.472398261200022 1 41.5543 42.1452 38.6877 40.5108 GeneID:3992,Genbank:NM_013402.4,HGNC:HGNC:3574,MIM:606148 fatty acid desaturase 1 GO:0000248,GO:0005739,GO:0005789,GO:0006355,GO:0006636,GO:0007267,GO:0008654,GO:0009267,GO:0016020,GO:0016021,GO:0016491,GO:0019216,GO:0036109,GO:0043231,GO:0043651,GO:0045485,GO:0045595,GO:0046456 C-5 sterol desaturase activity|mitochondrion|endoplasmic reticulum membrane|regulation of transcription, DNA-templated|unsaturated fatty acid biosynthetic process|cell-cell signaling|phospholipid biosynthetic process|cellular response to starvation|membrane|integral component of membrane|oxidoreductase activity|regulation of lipid metabolic process|alpha-linolenic acid metabolic process|intracellular membrane-bounded organelle|linoleic acid metabolic process|omega-6 fatty acid desaturase activity|regulation of cell differentiation|icosanoid biosynthetic process hsa01040 Biosynthesis of unsaturated fatty acids FADS2 5029.04165774936 4505.51842266717 5552.56489283156 1.23239200729859 0.301461230894575 0.0235224294201518 0.618180525582328 49.266 47.6044 58.9614 63.9809 GeneID:9415,Genbank:NM_001281501.1,HGNC:HGNC:3575,MIM:606149 fatty acid desaturase 2 GO:0004768,GO:0005789,GO:0005887,GO:0006636,GO:0016020,GO:0016213,GO:0036109,GO:0043651 stearoyl-CoA 9-desaturase activity|endoplasmic reticulum membrane|integral component of plasma membrane|unsaturated fatty acid biosynthetic process|membrane|linoleoyl-CoA desaturase activity|alpha-linolenic acid metabolic process|linoleic acid metabolic process hsa00592,hsa01040,hsa03320 alpha-Linolenic acid metabolism|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway FADS3 1055.74143560816 1170.4328469905 941.050024225814 0.804018809490444 -0.314698842188178 0.0643892405310972 0.90091963811897 18.0647 18.019 13.045 16.4519 GeneID:3995,Genbank:NM_021727.4,HGNC:HGNC:3576,MIM:606150 fatty acid desaturase 3 GO:0005789,GO:0006636,GO:0016020,GO:0016021,GO:0016491 endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|membrane|integral component of membrane|oxidoreductase activity FAF1 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0 GeneID:11124,Genbank:NM_007051.2,HGNC:HGNC:3578,MIM:604460 Fas associated factor 1 GO:0005634,GO:0005635,GO:0005829,GO:0006915,GO:0007253,GO:0008219,GO:0010942,GO:0019887,GO:0019901,GO:0019904,GO:0030155,GO:0031072,GO:0031265,GO:0031334,GO:0031625,GO:0034098,GO:0042176,GO:0043065,GO:0043130,GO:0043161,GO:0048471,GO:0051059,GO:1902043 nucleus|nuclear envelope|cytosol|apoptotic process|cytoplasmic sequestering of NF-kappaB|cell death|positive regulation of cell death|protein kinase regulator activity|protein kinase binding|protein domain specific binding|regulation of cell adhesion|heat shock protein binding|CD95 death-inducing signaling complex|positive regulation of protein complex assembly|ubiquitin protein ligase binding|VCP-NPL4-UFD1 AAA ATPase complex|regulation of protein catabolic process|positive regulation of apoptotic process|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|perinuclear region of cytoplasm|NF-kappaB binding|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors hsa04217 Necroptosis FAF2 2729.36162796696 2823.22986232255 2635.49339361137 0.933502945963903 -0.0992735195480365 0.46936163286851 1 23.4857 24.0309 23.594 21.161 GeneID:23197,Genbank:XM_011534475.3,HGNC:HGNC:24666,MIM:616935 Fas associated factor family member 2 GO:0005576,GO:0005783,GO:0005811,GO:0006986,GO:0030433,GO:0030970,GO:0031625,GO:0034098,GO:0034389,GO:0035473,GO:0035578,GO:0043130,GO:0043312,GO:0055102 extracellular region|endoplasmic reticulum|lipid droplet|response to unfolded protein|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|ubiquitin protein ligase binding|VCP-NPL4-UFD1 AAA ATPase complex|lipid particle organization|lipase binding|azurophil granule lumen|ubiquitin binding|neutrophil degranulation|lipase inhibitor activity FAH 561.379082433029 594.090639332722 528.667525533336 0.88987688162724 -0.168322348193346 0.41331198764644 1 11.5126 12.5995 9.81857 11.7156 GeneID:2184,Genbank:XM_024449872.1,HGNC:HGNC:3579,MIM:613871 fumarylacetoacetate hydrolase GO:0004334,GO:0005829,GO:0006527,GO:0006559,GO:0006572,GO:0046872,GO:0070062 fumarylacetoacetase activity|cytosol|arginine catabolic process|L-phenylalanine catabolic process|tyrosine catabolic process|metal ion binding|extracellular exosome hsa00350 Tyrosine metabolism FAHD1 587.209129301663 565.752741913457 608.66551668987 1.07585075881608 0.105477962235583 0.528457654248135 1 9.1269 8.92283 9.45623 10.1158 GeneID:81889,Genbank:NM_001018104.2,HGNC:HGNC:14169,MIM:616320 fumarylacetoacetate hydrolase domain containing 1 GO:0005654,GO:0005739,GO:0005743,GO:0005829,GO:0008152,GO:0008948,GO:0018773,GO:0034545,GO:0046872,GO:0047621 nucleoplasm|mitochondrion|mitochondrial inner membrane|cytosol|metabolic process|oxaloacetate decarboxylase activity|acetylpyruvate hydrolase activity|fumarylpyruvate hydrolase activity|metal ion binding|acylpyruvate hydrolase activity hsa00350 Tyrosine metabolism FAHD2A 1203.63178131266 1154.5790913402 1252.68447128513 1.08497068817612 0.117656067006917 0.519317452394599 1 4.29369 4.87466 4.93967 5.16723 GeneID:51011,Genbank:XM_017004237.2,HGNC:HGNC:24252 fumarylacetoacetate hydrolase domain containing 2A GO:0008152,GO:0016787,GO:0046872 metabolic process|hydrolase activity|metal ion binding FAHD2B 199.154749647542 203.991113725537 194.318385569548 0.952582600392074 -0.0700838978097427 0.752349486456447 1 0.837232 1.08524 0.916382 1.08362 GeneID:151313,Genbank:XM_017003470.1,HGNC:HGNC:25318 fumarylacetoacetate hydrolase domain containing 2B GO:0008152,GO:0016787,GO:0046872 metabolic process|hydrolase activity|metal ion binding FAIM 114.70896004448 105.853388821081 123.564531267879 1.1673176706391 0.223197225560687 0.428447822492574 1 1.70155 1.4482 1.66192 2.07918 GeneID:55179,Genbank:XM_011512950.3,HGNC:HGNC:18703,MIM:617535 Fas apoptotic inhibitory molecule GO:0005737,GO:0006915,GO:0043066 cytoplasm|apoptotic process|negative regulation of apoptotic process FAIM2 91.3924279291481 67.9071854622629 114.877670396033 1.69168652203783 0.758462254627338 0.0346182773203892 0.730000079237491 0.586289 0.472711 1.18452 0.754484 GeneID:23017,Genbank:NM_012306.3,HGNC:HGNC:17067,MIM:604306 Fas apoptotic inhibitory molecule 2 GO:0002931,GO:0005783,GO:0005794,GO:0006915,GO:0016021,GO:0021549,GO:0021680,GO:0021681,GO:0021702,GO:0030054,GO:0043066,GO:0043523,GO:0043524,GO:0045121,GO:0045211,GO:1902042 response to ischemia|endoplasmic reticulum|Golgi apparatus|apoptotic process|integral component of membrane|cerebellum development|cerebellar Purkinje cell layer development|cerebellar granular layer development|cerebellar Purkinje cell differentiation|cell junction|negative regulation of apoptotic process|regulation of neuron apoptotic process|negative regulation of neuron apoptotic process|membrane raft|postsynaptic membrane|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors FAM102A 461.363456361825 464.30120405574 458.42570866791 0.98734550904347 -0.0183730690123663 0.901236666701977 1 4.41963 4.91788 4.48384 5.02539 GeneID:399665,Genbank:NM_001035254.2,HGNC:HGNC:31419,MIM:610891 family with sequence similarity 102 member A FAM102B 306.781224204881 286.839555619091 326.72289279067 1.13904406275312 0.187823557305772 0.67066073826554 1 2.5864 2.18021 3.57588 1.93851 GeneID:284611,Genbank:NM_001010883.2,HGNC:HGNC:27637 family with sequence similarity 102 member B FAM103A1 594.59545014407 643.048736252919 546.142164035222 0.849301356562215 -0.235651540549513 0.155628927646078 1 17.6013 19.7265 14.719 16.357 GeneID:83640,Genbank:NM_031452.3,HGNC:HGNC:31022,MIM:614547 family with sequence similarity 103 member A1 GO:0003723,GO:0005634,GO:0005654,GO:0005845,GO:0006370,GO:0031533,GO:0032259,GO:0036031,GO:0106005 RNA binding|nucleus|nucleoplasm|mRNA cap binding complex|7-methylguanosine mRNA capping|mRNA cap methyltransferase complex|methylation|recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex|RNA 5'-cap (guanine-N7)-methylation FAM104A 1441.74604862149 1467.37179695196 1416.12030029103 0.965072589804857 -0.0512906333223516 0.722190798240394 1 13.8161 14.5174 14.8284 12.9142 GeneID:84923,Genbank:NM_001289410.1,HGNC:HGNC:25918 family with sequence similarity 104 member A FAM104B 174.587764482141 186.338734599964 162.836794364318 0.87387517530319 -0.194500875610105 0.433712703290062 1 1.06679 0.900115 0.870858 0.841119 GeneID:90736,Genbank:NM_138362.3,HGNC:HGNC:25085 family with sequence similarity 104 member B FAM106A 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0197224 0 0.0188703 GeneID:80039,Genbank:NM_024974.2,HGNC:HGNC:25682 family with sequence similarity 106 member A FAM106B 2.99408700392252 2.59443583384164 3.3937381740034 1.30808329492513 0.387454410369118 0.921804490449894 1 0.108411 0.0673196 0.13698 0.0637036 GeneID:100996259,Genbank:NM_001348161.1,HGNC:HGNC:32450 family with sequence similarity 106 member B FAM107A 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0092021 0 0 GeneID:11170,Genbank:NM_001282714.1,HGNC:HGNC:30827,MIM:608295 family with sequence similarity 107 member A FAM107B 492.741639786101 539.616278476301 445.867001095901 0.82626677303895 -0.275320441568696 0.115744928258469 1 4.29757 4.45435 3.74208 3.4041 GeneID:83641,Genbank:NM_031453.3,HGNC:HGNC:23726 family with sequence similarity 107 member B FAM110A 119.479818911551 112.474257075059 126.485380748043 1.12457182681041 0.169375809513998 0.561274982217776 1 2.16946 2.19641 2.5854 2.77726 GeneID:83541,Genbank:NM_001289145.1,HGNC:HGNC:16188,MIM:611393 family with sequence similarity 110 member A GO:0000922,GO:0005737,GO:0005815 spindle pole|cytoplasm|microtubule organizing center FAM110B 68.2500100754627 73.980147384491 62.5198727664343 0.845089865008038 -0.242823332299676 0.503509591409413 1 0.181449 0.163846 0.148935 0.136468 GeneID:90362,Genbank:XM_005251324.3,HGNC:HGNC:28587,MIM:611394 family with sequence similarity 110 member B GO:0005739,GO:0005815,GO:0005829 mitochondrion|microtubule organizing center|cytosol FAM110C 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0301035 0 GeneID:642273,Genbank:XM_017004691.1,HGNC:HGNC:33340,MIM:611395 family with sequence similarity 110 member C GO:0000922,GO:0005634,GO:0005815,GO:0005874,GO:0005938,GO:0030335,GO:0043014,GO:0051897,GO:0060491 spindle pole|nucleus|microtubule organizing center|microtubule|cell cortex|positive regulation of cell migration|alpha-tubulin binding|positive regulation of protein kinase B signaling|regulation of cell projection assembly FAM110D 3.26563739192876 3.6226049124413 2.90866987141623 0.802922190445562 -0.316667909009492 0.956952753614095 1 0.0525779 0.133325 0.0961405 0.0897633 GeneID:79927,Genbank:NM_024869.2,HGNC:HGNC:25860 family with sequence similarity 110 member D FAM111A 898.912978950066 905.988429033975 891.837528866156 0.984380705410434 -0.0227117147035264 0.964241610346696 1 8.52766 6.74883 9.02004 6.19114 GeneID:63901,Genbank:NM_001312910.1,HGNC:HGNC:24725,MIM:615292 family with sequence similarity 111 member A GO:0000785,GO:0001650,GO:0005634,GO:0005737,GO:0006260,GO:0016032,GO:0045071,GO:0051607 chromatin|fibrillar center|nucleus|cytoplasm|DNA replication|viral process|negative regulation of viral genome replication|defense response to virus FAM111B 145.971872576916 149.958797996389 141.984947157444 0.946826388678197 -0.0788281793887293 0.79070314494952 1 1.35429 1.19427 1.17391 1.30067 GeneID:374393,Genbank:NM_198947.3,HGNC:HGNC:24200,MIM:615584 family with sequence similarity 111 member B FAM114A1 1377.58398492129 1261.95747829438 1493.2104915482 1.18324944955069 0.242754250932672 0.0927716876570395 0.987898138646211 7.13208 6.53619 8.66516 7.27671 GeneID:92689,Genbank:NM_138389.3,HGNC:HGNC:25087 family with sequence similarity 114 member A1 GO:0005634,GO:0005654,GO:0005794,GO:0005829 nucleus|nucleoplasm|Golgi apparatus|cytosol FAM114A2 361.364195616616 348.107272518014 374.621118715218 1.07616573479036 0.105900277102307 0.568160453768219 1 1.77036 1.69709 2.00811 1.8127 GeneID:10827,Genbank:NM_001317995.1,HGNC:HGNC:1333 family with sequence similarity 114 member A2 GO:0017076 purine nucleotide binding FAM117A 95.0789528127594 84.9920409458698 105.165864679649 1.23736132829929 0.307266850699338 0.307286957114845 1 1.28101 0.854181 1.33792 1.22761 GeneID:81558,Genbank:NM_030802.3,HGNC:HGNC:24179 family with sequence similarity 117 member A FAM117B 62.1834645771599 62.3242949419922 62.0426342123277 0.995480723369167 -0.00653471522382118 1 1 0.517964 0.485258 0.578708 0.406083 GeneID:150864,Genbank:NM_173511.3,HGNC:HGNC:14440 family with sequence similarity 117 member B FAM118A 354.179514981618 381.730094154333 326.628935808903 0.855654141003743 -0.224900323830867 0.231471817653374 1 1.67442 1.93954 1.63169 1.67972 GeneID:55007,Genbank:NM_001104595.2,HGNC:HGNC:1313 family with sequence similarity 118 member A GO:0016021,GO:0042802 integral component of membrane|identical protein binding FAM118B 620.698234126374 615.306771440089 626.089696812658 1.01752447051303 0.0250634903768147 0.881556626149646 1 4.66059 4.91513 4.5341 5.05664 GeneID:79607,Genbank:XM_017018286.1,HGNC:HGNC:26110,MIM:616587 family with sequence similarity 118 member B GO:0015030,GO:0030576 Cajal body|Cajal body organization FAM120A 4127.18901420233 4078.46940281273 4175.90862559192 1.02389112511473 0.0340623153301892 0.789082887893553 1 12.7788 12.5242 14.7776 11.6026 GeneID:23196,Genbank:NM_014612.4,HGNC:HGNC:13247,MIM:612265 family with sequence similarity 120A GO:0003723,GO:0005634,GO:0005829,GO:0005886,GO:0016020 RNA binding|nucleus|cytosol|plasma membrane|membrane FAM120AOS 770.658427726559 744.087654948688 797.229200504429 1.07141839432803 0.0995219698635098 0.536634165210903 1 8.44425 8.3887 9.42702 8.92238 GeneID:158293,Genbank:NM_198841.3,HGNC:HGNC:23389 family with sequence similarity 120A opposite strand FAM120B 1266.64479216072 1321.66975409402 1211.61983022742 0.916734173929827 -0.125424639748115 0.391115431704485 1 5.57662 5.90849 5.68998 4.95921 GeneID:84498,Genbank:NM_001286379.1,HGNC:HGNC:21109,MIM:612266 family with sequence similarity 120B GO:0005634,GO:0006351,GO:0006355,GO:0035357,GO:0045444 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|peroxisome proliferator activated receptor signaling pathway|fat cell differentiation FAM120C 414.079802779498 421.040650514545 407.118955044451 0.966935032393951 -0.0485091354766271 0.787065230955338 1 1.81312 1.97276 2.07154 1.62651 GeneID:54954,Genbank:NM_001300788.1,HGNC:HGNC:16949,MIM:300741 family with sequence similarity 120C GO:0003723,GO:0005634 RNA binding|nucleus FAM122A 263.592805818121 255.293706451043 271.891905185199 1.06501609054487 0.0908752272341423 0.67266678132027 1 3.19677 3.3436 3.83759 3.26809 GeneID:116224,Genbank:NM_138333.4,HGNC:HGNC:23490,MIM:617249 family with sequence similarity 122A FAM122B 2082.277057664 2123.12112103363 2041.43299429437 0.961524509397991 -0.0566044623494673 0.705293257247658 1 23.9523 22.8696 25.6959 19.9195 GeneID:159090,Genbank:NM_001170757.1,HGNC:HGNC:30490 family with sequence similarity 122B FAM122C 90.9337074140079 84.4539432692275 97.4134715587882 1.15345083708226 0.205956514112669 0.503870634062435 1 0.376536 0.282678 0.386332 0.349107 GeneID:159091,Genbank:NM_001170780.1,HGNC:HGNC:25202 family with sequence similarity 122C GO:0005829,GO:0016020,GO:0042803,GO:0070062 cytosol|membrane|protein homodimerization activity|extracellular exosome FAM124A 182.368622344015 173.290120191602 191.447124496427 1.10477806977541 0.143756587000171 0.563596229365065 1 0.921354 1.06164 1.2144 0.997538 GeneID:220108,Genbank:NM_145019.3,HGNC:HGNC:26413 family with sequence similarity 124 member A FAM126A 1107.27053031123 1138.98879102351 1075.55226959895 0.944304525273198 -0.0826759108788974 0.794587182665508 1 7.15131 6.01633 7.63467 5.08653 GeneID:84668,Genbank:XM_011515590.2,HGNC:HGNC:24587,MIM:610531 family with sequence similarity 126 member A GO:0004871,GO:0005829,GO:0005886,GO:0042552,GO:0043005,GO:0046854,GO:0072659 signal transducer activity|cytosol|plasma membrane|myelination|neuron projection|phosphatidylinositol phosphorylation|protein localization to plasma membrane FAM126B 93.6152144588412 96.1097957117263 91.120633205956 0.948088928201087 -0.0769057084878878 0.824858253939018 1 0.360454 0.35001 0.397154 0.268216 GeneID:285172,Genbank:NM_001321618.1,HGNC:HGNC:28593 family with sequence similarity 126 member B GO:0005622,GO:0005829,GO:0005886 intracellular|cytosol|plasma membrane FAM129A 3969.59841976066 3778.22441455141 4160.97242496992 1.1013036729487 0.139212331799482 0.401174078895132 1 18.782 17.916 23.4201 17.576 GeneID:116496,Genbank:NM_052966.3,HGNC:HGNC:16784 family with sequence similarity 129 member A GO:0001933,GO:0001934,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0034976,GO:0045727,GO:0070062 negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|cytoplasm|cytosol|plasma membrane|membrane|response to endoplasmic reticulum stress|positive regulation of translation|extracellular exosome FAM129B 6401.80797394397 6571.09963727137 6232.51631061657 0.948473871141087 -0.0763200645235724 0.540527384021152 1 57.6485 61.664 56.1973 60.2402 GeneID:64855,Genbank:NM_001035534.2,HGNC:HGNC:25282,MIM:614045 family with sequence similarity 129 member B GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0007411,GO:0008285,GO:0016525,GO:0030154,GO:0030948,GO:0032274,GO:0034337,GO:0040019,GO:0043066,GO:0044029,GO:0045296,GO:0045746,GO:0045892,GO:0045893,GO:0048743,GO:0070062,GO:2000279,GO:2000679 transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|adherens junction|axon guidance|negative regulation of cell proliferation|negative regulation of angiogenesis|cell differentiation|negative regulation of vascular endothelial growth factor receptor signaling pathway|gonadotropin secretion|RNA folding|positive regulation of embryonic development|negative regulation of apoptotic process|hypomethylation of CpG island|cadherin binding|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of skeletal muscle fiber development|extracellular exosome|negative regulation of DNA biosynthetic process|positive regulation of transcription regulatory region DNA binding FAM129C 4.00030950883811 5.09281911831339 2.90779989936283 0.570960764914387 -0.808536484515101 0.647982717953022 1 0.0605963 0.0811797 0.0664259 0.0443424 GeneID:199786,Genbank:NM_173544.4,HGNC:HGNC:24130,MIM:609967 family with sequence similarity 129 member C FAM131A 708.633285188243 646.729176095153 770.537394281334 1.19143750237729 0.252703276014012 0.124419073799614 1 8.81944 9.47724 11.0678 11.0943 GeneID:131408,Genbank:XM_005247113.3,HGNC:HGNC:28308 family with sequence similarity 131 member A GO:0005576 extracellular region FAM131B 61.500214277654 66.7829638342934 56.2174647210147 0.84179349782237 -0.248461728824039 0.514509052580683 1 0.224441 0.17585 0.243304 0.196352 GeneID:9715,Genbank:NM_001278297.1,HGNC:HGNC:22202 family with sequence similarity 131 member B GO:0005654,GO:0005829 nucleoplasm|cytosol FAM131C 11.5294321765025 13.3661980217957 9.69266633120943 0.725162556727353 -0.463623660453887 0.618551524480561 1 0.20239 0.321284 0.239171 0.199224 GeneID:348487,Genbank:NM_182623.2,HGNC:HGNC:26717 family with sequence similarity 131 member C FAM133A 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0126292 0 GeneID:286499,Genbank:XM_011530926.3,HGNC:HGNC:26748 family with sequence similarity 133 member A FAM133B 282.382154858994 311.313699751635 253.450609966352 0.814132529884018 -0.296664429826824 0.21676391960994 1 2.12115 1.80814 1.6315 1.63609 GeneID:257415,Genbank:NM_152789.3,HGNC:HGNC:28629 family with sequence similarity 133 member B GO:0003723 RNA binding FAM135A 72.8709822032327 76.4206957391699 69.3212686672955 0.907100727058212 -0.140665334256188 0.795489380531348 1 0.457413 0.357925 0.461755 0.191658 GeneID:57579,Genbank:NM_001351607.1,HGNC:HGNC:21084 family with sequence similarity 135 member A GO:0044255,GO:0052689 cellular lipid metabolic process|carboxylic ester hydrolase activity FAM136A 1586.796679744 1550.11437764103 1623.47898184696 1.04732851024682 0.0667140361244981 0.634635955482958 1 22.1401 21.3248 23.0357 23.11 GeneID:84908,Genbank:NM_032822.2,HGNC:HGNC:25911,MIM:616275 family with sequence similarity 136 member A GO:0005737,GO:0005739 cytoplasm|mitochondrion FAM13A 130.60057384917 130.327532953625 130.873614744716 1.00419007234093 0.00603236736666599 0.983370804379317 1 0.322062 0.286418 0.396466 0.25642 GeneID:10144,Genbank:NM_014883.3,HGNC:HGNC:19367,MIM:613299 family with sequence similarity 13 member A GO:0005096,GO:0005829,GO:0007165,GO:0051056 GTPase activator activity|cytosol|signal transduction|regulation of small GTPase mediated signal transduction FAM13B 888.853524092015 906.219768753147 871.487279430883 0.961673216012434 -0.0563813565368959 0.84515978364563 1 5.11968 4.34838 5.48297 3.78432 GeneID:51306,Genbank:NM_001101801.2,HGNC:HGNC:1335,MIM:609371 family with sequence similarity 13 member B GO:0005096,GO:0005829,GO:0007165,GO:0051056 GTPase activator activity|cytosol|signal transduction|regulation of small GTPase mediated signal transduction FAM13C 283.010556257839 301.887690255714 264.133422259964 0.874939359190928 -0.192745065629511 0.355688203100703 1 1.65729 1.52653 1.55489 1.3534 GeneID:220965,Genbank:XM_017015889.1,HGNC:HGNC:19371 family with sequence similarity 13 member C FAM149A 77.2521381910611 75.9884592670054 78.5158171151168 1.0332597590804 0.047202989950446 0.904525545507811 1 0.631845 0.74107 0.894373 0.752517 GeneID:25854,Genbank:NM_001006655.3,HGNC:HGNC:24527 family with sequence similarity 149 member A FAM149B1 433.714280874436 390.041690677392 477.386871071479 1.22393806221687 0.291530551826721 0.108276297922133 1 1.66763 1.85312 2.43399 2.00604 GeneID:317662,Genbank:XM_017016164.1,HGNC:HGNC:29162 family with sequence similarity 149 member B1 FAM151A 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0 0.0193683 0.0206499 0 GeneID:338094,Genbank:NM_176782.2,HGNC:HGNC:25032 family with sequence similarity 151 member A GO:0016020,GO:0016021,GO:0070062 membrane|integral component of membrane|extracellular exosome FAM151B 31.3239511894642 31.6331100631649 31.0147923157634 0.980453463280502 -0.0284789396231822 0.97796824181857 1 0.117028 0.12232 0.133327 0.161698 GeneID:167555,Genbank:NM_205548.2,HGNC:HGNC:33716 family with sequence similarity 151 member B GO:0006629,GO:0008081 lipid metabolic process|phosphoric diester hydrolase activity FAM155A 66.5877397092974 56.5973255976666 76.5781538209283 1.3530348477117 0.436198996722752 0.218129301589051 1 0.423953 0.366954 0.616914 0.482087 GeneID:728215,Genbank:XM_011521109.3,HGNC:HGNC:33877 family with sequence similarity 155 member A GO:0005886,GO:0016021,GO:0098703 plasma membrane|integral component of membrane|calcium ion import across plasma membrane FAM156A 6.66481365132905 4.60274771635603 8.72687958630208 1.89601519007674 0.922970522548727 0.45253210497368 1 0.00853858 0.00773918 0 0 GeneID:29057,Genbank:NM_001242497.1,HGNC:HGNC:30114 family with sequence similarity 156 member A GO:0005635,GO:0016021,GO:0035064 nuclear envelope|integral component of membrane|methylated histone binding FAM156B 0.998282869833606 1.02816907859967 0.968396661067546 0.941865186596032 -0.0864075197076174 1 1 0.0116802 0.0103642 0 0.020371 GeneID:727866,Genbank:NM_001321181.1,HGNC:HGNC:31962 family with sequence similarity 156 member B GO:0005635,GO:0016021,GO:0035064 nuclear envelope|integral component of membrane|methylated histone binding FAM160A1 232.444943238115 207.98812018035 256.90176629588 1.23517519208845 0.30471568215971 0.348908813746471 1 0.600287 0.594966 0.91728 0.56468 GeneID:729830,Genbank:XM_024454201.1,HGNC:HGNC:34237 family with sequence similarity 160 member A1 FAM160A2 331.751860112454 320.385942016255 343.117778208654 1.07095141581226 0.0988930330698927 0.636584580415981 1 3.15039 3.45029 3.62063 3.304 GeneID:84067,Genbank:NM_001098794.1,HGNC:HGNC:25378 family with sequence similarity 160 member A2 GO:0005829,GO:0007032,GO:0007040,GO:0008333,GO:0015031,GO:0045022,GO:0070695 cytosol|endosome organization|lysosome organization|endosome to lysosome transport|protein transport|early endosome to late endosome transport|FHF complex FAM160B1 246.515598471838 277.826165285119 215.205031658558 0.774603181949058 -0.368470667142716 0.230525497253836 1 2.2267 1.84912 1.8883 1.26129 GeneID:57700,Genbank:NM_001135051.1,HGNC:HGNC:29320,MIM:617312 family with sequence similarity 160 member B1 FAM160B2 1075.29499470078 970.976837396419 1179.61315200515 1.21487259692844 0.280805027068171 0.0631807546775419 0.894697583479674 7.86545 7.09271 9.64277 8.9584 GeneID:64760,Genbank:NM_001354251.1,HGNC:HGNC:16492 family with sequence similarity 160 member B2 FAM161A 87.7135458086323 94.4955026817994 80.9315889354652 0.856459690023463 -0.223542748603521 0.489529134976553 1 0.699379 0.711959 0.656068 0.65184 GeneID:84140,Genbank:NM_032180.2,HGNC:HGNC:25808,MIM:613596 family with sequence similarity 161 member A GO:0000235,GO:0001917,GO:0005813,GO:0005876,GO:0007601,GO:0008017,GO:0032391,GO:0036064,GO:0042802,GO:0050896,GO:0060271,GO:0072686,GO:0097431,GO:1901985 astral microtubule|photoreceptor inner segment|centrosome|spindle microtubule|visual perception|microtubule binding|photoreceptor connecting cilium|ciliary basal body|identical protein binding|response to stimulus|cilium assembly|mitotic spindle|mitotic spindle pole|positive regulation of protein acetylation FAM161B 102.534451012598 101.356502309202 103.712399715994 1.0232436731055 0.033149746372944 0.936615639933956 1 0.732116 0.789612 0.867776 0.721281 GeneID:145483,Genbank:XM_011536475.2,HGNC:HGNC:19854 family with sequence similarity 161 member B GO:0005881,GO:0015630 cytoplasmic microtubule|microtubule cytoskeleton FAM162A 554.326546600494 586.797403233155 521.855689967834 0.889328560577292 -0.169211576683608 0.550077424206054 1 26.442 30.9485 21.3018 29.3493 GeneID:26355,Genbank:NM_014367.3,HGNC:HGNC:17865,MIM:608017 family with sequence similarity 162 member A GO:0005739,GO:0005829,GO:0006919,GO:0016021,GO:0043065,GO:0051402,GO:0070062,GO:0071456,GO:0090200 mitochondrion|cytosol|activation of cysteine-type endopeptidase activity involved in apoptotic process|integral component of membrane|positive regulation of apoptotic process|neuron apoptotic process|extracellular exosome|cellular response to hypoxia|positive regulation of release of cytochrome c from mitochondria FAM163A 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0.00935135 0.0197231 0 GeneID:148753,Genbank:NM_001329714.1,HGNC:HGNC:28274,MIM:611727 family with sequence similarity 163 member A GO:0016021 integral component of membrane FAM166A 200.767419243036 221.296483272353 180.238355213719 0.814465519508037 -0.296074471505168 0.449548370169314 1 0.182791 0.0451932 0.0240131 0.112571 GeneID:401565,Genbank:NM_001001710.2,HGNC:HGNC:33818 family with sequence similarity 166 member A GO:0005634 nucleus FAM166B 2.26604956401506 2.59443583384164 1.93766329418849 0.746853427212863 -0.42110295840788 0.964656809965331 1 0 0.027997 0.0293406 0.0274383 GeneID:730112,Genbank:NM_001099951.3,HGNC:HGNC:34242 family with sequence similarity 166 member B FAM167A 2.99909010329271 3.57457863775636 2.42360156882906 0.678010421488522 -0.560620646135981 0.840082749326871 1 0.0238789 0.0283727 0.022391 0.0139591 GeneID:83648,Genbank:NM_053279.2,HGNC:HGNC:15549,MIM:610085 family with sequence similarity 167 member A FAM167B 19.3502989555557 17.3828217868244 21.317776124287 1.22637028589024 0.294394647022791 0.682664273850265 1 0.67093 0.423169 0.558168 1.24885 GeneID:84734,Genbank:NM_032648.2,HGNC:HGNC:28133 family with sequence similarity 167 member B FAM168A 2358.42793013949 2205.93541331102 2510.92044696797 1.13825655629653 0.186825769226867 0.184229002228746 1 10.5528 11.6027 13.3856 12.2034 GeneID:23201,Genbank:NM_001286051.1,HGNC:HGNC:28999,MIM:616316 family with sequence similarity 168 member A GO:1905053 positive regulation of base-excision repair FAM168B 3972.92317596954 4258.81262773047 3687.0337242086 0.865742178982272 -0.20799064555115 0.124275908759402 1 32.0847 30.9208 27.9442 26.9955 GeneID:130074,Genbank:XM_017003328.1,HGNC:HGNC:27016 family with sequence similarity 168 member B GO:0005886,GO:0016021,GO:0030424,GO:0048471,GO:0070062 plasma membrane|integral component of membrane|axon|perinuclear region of cytoplasm|extracellular exosome FAM169A 129.70680491036 156.175838742671 103.237771078048 0.661035483524127 -0.597200379084337 0.0276566271927897 0.66709117638512 0.88381 0.760423 0.632157 0.488 GeneID:26049,Genbank:NM_015566.2,HGNC:HGNC:29138,MIM:615769 family with sequence similarity 169 member A GO:0005637 nuclear inner membrane FAM170A 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0203827 0 GeneID:340069,Genbank:NM_182761.3,HGNC:HGNC:27963 family with sequence similarity 170 member A GO:0003677,GO:0005634,GO:0006366,GO:0045893,GO:0046872 DNA binding|nucleus|transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-templated|metal ion binding FAM171A1 700.874505038666 664.610860938188 737.138149139145 1.10912744955533 0.149425154748277 0.356337585854772 1 5.64465 5.32041 6.5032 5.85839 GeneID:221061,Genbank:XM_017015904.1,HGNC:HGNC:23522 family with sequence similarity 171 member A1 GO:0016021,GO:0070062 integral component of membrane|extracellular exosome FAM171A2 144.332429871274 132.633811139357 156.03104860319 1.17640477388718 0.234384543850864 0.359238359639995 1 2.66322 1.95665 2.69727 2.82187 GeneID:284069,Genbank:XM_017024490.1,HGNC:HGNC:30480 family with sequence similarity 171 member A2 GO:0016021 integral component of membrane FAM171B 74.4601882970083 85.4242774180343 63.4960991759824 0.74330273658923 -0.427978175346179 0.29200679397793 1 0.888982 0.616925 0.660606 0.442605 GeneID:165215,Genbank:NM_177454.3,HGNC:HGNC:29412 family with sequence similarity 171 member B GO:0016021 integral component of membrane FAM172A 400.537368779494 389.608437204373 411.466300354615 1.0561021298899 0.0787493566292495 0.647444511177307 1 0.428832 0.353961 0.46908 0.402344 GeneID:83989,Genbank:XM_005272108.3,HGNC:HGNC:25365 family with sequence similarity 172 member A GO:0005576,GO:0005783 extracellular region|endoplasmic reticulum FAM173A 371.871939953109 390.455326840195 353.288553066023 0.904811712840625 -0.144310489666934 0.428482881777016 1 35.913 38.7886 35.8094 34.0601 GeneID:65990,Genbank:NM_023933.2,HGNC:HGNC:14152 family with sequence similarity 173 member A GO:0016021 integral component of membrane FAM173B 323.186770158248 303.261851912217 343.11168840428 1.13140405310061 0.178114244361676 0.356988208858043 1 4.52503 4.50138 4.69001 4.82912 GeneID:134145,Genbank:NM_001258389.1,HGNC:HGNC:27029 family with sequence similarity 173 member B GO:0016021 integral component of membrane FAM174A 591.316961542794 598.635552119285 583.998370966303 0.975549094768655 -0.0357136162129755 0.824540650679709 1 16.3899 16.9272 17.7329 15.7451 GeneID:345757,Genbank:NM_198507.2,HGNC:HGNC:24943 family with sequence similarity 174 member A GO:0016021 integral component of membrane FAM174B 46.7164093442095 43.0292138220232 50.4036048663958 1.17138103138195 0.228210437640338 0.575647853235714 1 1.0197 0.595279 1.03996 0.821242 GeneID:400451,Genbank:NM_207446.2,HGNC:HGNC:34339 family with sequence similarity 174 member B GO:0016021 integral component of membrane FAM177A1 662.708488883732 649.822474985205 675.594502782258 1.03966010531975 0.056111947099088 0.732085704715079 1 6.76845 6.98467 7.45845 6.47724 GeneID:283635,Genbank:NM_001079519.1,HGNC:HGNC:19829 family with sequence similarity 177 member A1 FAM177B 1.2378804854154 0.538097676642304 1.93766329418849 3.60095086505369 1.84837791409998 0.680650629779701 1 0 0 0 0 GeneID:400823,Genbank:NM_207468.2,HGNC:HGNC:34395 family with sequence similarity 177 member B FAM180A 1.99449917600881 1.56626675524197 2.42273159677566 1.54681926859986 0.629304641178248 0.890491782532693 1 0.0173693 0.00809704 0.0165248 0.0231572 GeneID:389558,Genbank:NM_205855.3,HGNC:HGNC:33773 family with sequence similarity 180 member A GO:0005576 extracellular region FAM180B 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0 0 0 0 GeneID:399888,Genbank:NM_001164379.1,HGNC:HGNC:34451 family with sequence similarity 180 member B GO:0016021 integral component of membrane FAM181B 0.998282869833606 1.02816907859967 0.968396661067546 0.941865186596032 -0.0864075197076174 1 1 0.0385448 0.0325872 0 0.0653712 GeneID:220382,Genbank:NM_175885.3,HGNC:HGNC:28512 family with sequence similarity 181 member B FAM184A 64.5093982367182 72.7882821716207 56.2305143018156 0.772521518906505 -0.372352974443416 0.552933502102252 1 0.554817 0.33571 0.482294 0.254903 GeneID:79632,Genbank:NM_001288576.1,HGNC:HGNC:20991 family with sequence similarity 184 member A GO:0005615 extracellular space FAM184B 6.88953435625536 6.02493564754317 7.75413306496754 1.28700678622675 0.364019660730232 0.825764330802121 1 0.0171626 0.0309931 0.0644076 0.0450186 GeneID:27146,Genbank:NM_015688.1,HGNC:HGNC:29235 family with sequence similarity 184 member B FAM185A 95.7968396551996 102.422889007379 89.1707903030199 0.870613894679299 -0.19989504969268 0.529435529140028 1 0.454719 0.376763 0.391544 0.37463 GeneID:222234,Genbank:XM_017011847.2,HGNC:HGNC:22412 family with sequence similarity 185 member A GO:0005829 cytosol FAM186B 3.70224443380429 3.52655236307142 3.87793650453717 1.09963956444977 0.13703072030165 1 1 0.00853777 0.0386141 0.0321157 0.0224558 GeneID:84070,Genbank:XM_017020008.2,HGNC:HGNC:25296 family with sequence similarity 186 member B GO:0043234 protein complex FAM187A 47.6687291914807 38.1481171126655 57.1893412702958 1.49913929176097 0.584134436785877 0.170044839549225 1 0.811223 1.20602 1.87376 1.50125 GeneID:100528020,Genbank:NM_001258400.1,HGNC:HGNC:35153 family with sequence similarity 187 member A GO:0016021 integral component of membrane FAM189A1 126.629991452767 136.468138460754 116.79184444478 0.85581767115822 -0.224624626455144 0.400289269313118 1 1.09007 1.24514 0.976173 1.03641 GeneID:23359,Genbank:NM_015307.1,HGNC:HGNC:29075 family with sequence similarity 189 member A1 GO:0016021 integral component of membrane FAM189A2 21.9031249386378 22.9657123070952 20.8405375701804 0.907463147299888 -0.140089039423337 0.842781206485188 1 0.248665 0.304171 0.299886 0.206967 GeneID:9413,Genbank:NM_001127608.2,HGNC:HGNC:24820,MIM:607710 family with sequence similarity 189 member A2 GO:0016021 integral component of membrane FAM189B 1336.46757004767 1292.11259949827 1380.82254059706 1.06865496175274 0.095796123105281 0.526139517506918 1 16.3446 16.1369 19.8127 15.4598 GeneID:10712,Genbank:XM_005244845.2,HGNC:HGNC:1233 family with sequence similarity 189 member B GO:0016021,GO:0050699 integral component of membrane|WW domain binding FAM192A 2469.46399941887 2515.3172364193 2423.61076241843 0.963540792122344 -0.0535823496462243 0.696929964857927 1 11.6719 11.849 11.7027 10.8441 GeneID:80011,Genbank:XM_005256156.5,HGNC:HGNC:29856,MIM:617766 family with sequence similarity 192 member A GO:0005634 nucleus FAM193A 871.614615492479 837.44912734741 905.780103637548 1.08159418173445 0.113159296002856 0.468037768227587 1 4.36327 3.90459 4.74938 4.37717 GeneID:8603,Genbank:XM_024454266.1,HGNC:HGNC:16822 family with sequence similarity 193 member A FAM193B 376.597907250043 372.284467348196 380.91134715189 1.02317281691913 0.0330498411295728 0.886281060617551 1 2.67836 2.78692 2.95016 3.04888 GeneID:54540,Genbank:NM_001190946.2,HGNC:HGNC:25524,MIM:615813 family with sequence similarity 193 member B GO:0005634,GO:0005654,GO:0005737 nucleus|nucleoplasm|cytoplasm FAM196A 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0 0.00414745 0 0 GeneID:642938,Genbank:NM_001039762.2,HGNC:HGNC:33859,MIM:617129 family with sequence similarity 196 member A FAM196B 838.715694419095 878.15142867263 799.279960165559 0.910184660718153 -0.135768822020424 0.656567977010882 1 5.2436 4.37266 5.38411 3.4483 GeneID:100131897,Genbank:NM_001346304.1,HGNC:HGNC:37271 family with sequence similarity 196 member B FAM198B 1872.35093835436 1900.06219790387 1844.63967880484 0.970831207967734 -0.0427076093313372 0.901320217608542 1 18.5804 14.2456 17.7424 14.3983 GeneID:51313,Genbank:XM_024454079.1,HGNC:HGNC:25312 family with sequence similarity 198 member B GO:0000139,GO:0005794,GO:0016021 Golgi membrane|Golgi apparatus|integral component of membrane FAM199X 1027.94757843667 1007.03817338571 1048.85698348764 1.0415265391195 0.0586996011339958 0.759619187592452 1 7.14886 6.57296 8.22982 6.10233 GeneID:139231,Genbank:NM_207318.3,HGNC:HGNC:25195 family with sequence similarity 199, X-linked FAM19A1 0.780631827935889 1.07619535328461 0.48506830258717 0.450725141217823 -1.14968016979823 0.981241458110389 1 0.0249042 0 0.0119949 0 GeneID:407738,Genbank:NM_001252216.1,HGNC:HGNC:21587,MIM:617495 family with sequence similarity 19 member A1, C-C motif chemokine like GO:0005576,GO:0005783 extracellular region|endoplasmic reticulum FAM19A2 4.9363184114545 3.57457863775636 6.29805818515264 1.76190226132658 0.817133895308022 0.597302160828349 1 0.0165774 0.0156223 0.0158618 0.0516653 GeneID:338811,Genbank:NM_178539.4,HGNC:HGNC:21589,MIM:617496 family with sequence similarity 19 member A2, C-C motif chemokine like GO:0005737 cytoplasm FAM19A3 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0586611 0.0309539 0 GeneID:284467,Genbank:XM_006710582.4,HGNC:HGNC:21590,MIM:617497 family with sequence similarity 19 member A3, C-C motif chemokine like GO:0005615,GO:1903979,GO:1903980 extracellular space|negative regulation of microglial cell activation|positive regulation of microglial cell activation FAM200A 139.190084662895 153.84115159247 124.53901773332 0.809529936848287 -0.304843661741901 0.243672778381647 1 1.6719 1.63185 1.16444 1.30517 GeneID:221786,Genbank:XM_024446681.1,HGNC:HGNC:25401 family with sequence similarity 200 member A GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0016021 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|integral component of membrane FAM200B 346.130253107609 324.440783400861 367.819722814357 1.13370371923896 0.181043657358188 0.356863733639222 1 1.88282 2.40751 2.1376 2.3605 GeneID:285550,Genbank:XM_024454007.1,HGNC:HGNC:27740 family with sequence similarity 200 member B GO:0000981,GO:0003677,GO:0005654,GO:0005737 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm FAM204A 492.159105609589 539.914244779519 444.403966439659 0.82310102157267 -0.280858587232201 0.107965058338817 1 2.98533 3.35917 2.81054 2.65254 GeneID:63877,Genbank:XM_005270024.1,HGNC:HGNC:25794 family with sequence similarity 204 member A FAM206A 162.316880218078 160.336541331755 164.2972191044 1.02470227772002 0.0352048025612832 0.875369620546871 1 3.14714 2.59599 3.23733 2.73177 GeneID:54942,Genbank:NM_017832.3,HGNC:HGNC:1364 family with sequence similarity 206 member A GO:0016607,GO:0030425 nuclear speck|dendrite FAM207A 635.733019826495 638.571467051256 632.894572601733 0.991110009227726 -0.0128828952365547 0.914110702908038 1 5.90778 6.9366 5.73987 7.18088 GeneID:85395,Genbank:NM_001316988.1,HGNC:HGNC:15811 family with sequence similarity 207 member A FAM208A 550.77431941012 508.240883095067 593.307755725172 1.16737510786631 0.223268210834326 0.5833163913217 1 2.39319 1.73435 3.03512 1.81424 GeneID:23272,Genbank:XM_005264999.2,HGNC:HGNC:30314,MIM:616493 family with sequence similarity 208 member A GO:0003723,GO:0005654,GO:0005694,GO:0006351,GO:0006355 RNA binding|nucleoplasm|chromosome|transcription, DNA-templated|regulation of transcription, DNA-templated FAM208B 742.936946516571 761.728191417443 724.145701615699 0.950661548009914 -0.0729962868361929 0.820266272743524 1 1.42268 1.18926 1.4922 0.989169 GeneID:54906,Genbank:XM_005252480.5,HGNC:HGNC:23484 family with sequence similarity 208 member B GO:0005634,GO:0005654,GO:0005829 nucleus|nucleoplasm|cytosol FAM209A 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0834861 0 0 0 GeneID:200232,Genbank:NM_001012971.3,HGNC:HGNC:16100 family with sequence similarity 209 member A GO:0005634,GO:0016021,GO:0070062 nucleus|integral component of membrane|extracellular exosome FAM209B 4.20958592962714 3.57457863775636 4.84459322149792 1.35529071044264 0.438602343482676 0.847066537303963 1 0.0877752 0.0797356 0.0409988 0.115159 GeneID:388799,Genbank:XM_017027849.1,HGNC:HGNC:16101 family with sequence similarity 209 member B GO:0005634,GO:0016021 nucleus|integral component of membrane FAM20A 148.630386581773 179.525761247246 117.735011916299 0.655811239001806 -0.608647468677536 0.134848912411597 1 0.621161 0.519294 0.280265 0.45508 GeneID:54757,Genbank:XM_006721959.3,HGNC:HGNC:23015,MIM:611062 FAM20A, golgi associated secretory pathway pseudokinase GO:0001934,GO:0005615,GO:0005623,GO:0005783,GO:0005794,GO:0031214,GO:0043539,GO:0044691,GO:0055074,GO:0070062,GO:0070166 positive regulation of protein phosphorylation|extracellular space|cell|endoplasmic reticulum|Golgi apparatus|biomineral tissue development|protein serine/threonine kinase activator activity|tooth eruption|calcium ion homeostasis|extracellular exosome|enamel mineralization FAM20B 1590.39987196817 1770.01606494581 1410.78367899052 0.797045691804899 -0.327265663706949 0.0252182696304911 0.631315976879816 12.2899 10.7436 9.5966 8.71709 GeneID:9917,Genbank:NM_001324310.1,HGNC:HGNC:23017,MIM:611063 FAM20B, glycosaminoglycan xylosylkinase GO:0000139,GO:0005524,GO:0005615,GO:0005654,GO:0005794,GO:0016021,GO:0016301,GO:0016773,GO:0046872,GO:1903955 Golgi membrane|ATP binding|extracellular space|nucleoplasm|Golgi apparatus|integral component of membrane|kinase activity|phosphotransferase activity, alcohol group as acceptor|metal ion binding|positive regulation of protein targeting to mitochondrion FAM20C 6841.81229713463 7303.95386759462 6379.67072667464 0.873454411449566 -0.195195688931352 0.139858639886312 1 32.2726 34.7373 33.4712 26.33 GeneID:56975,Genbank:XM_017012453.1,HGNC:HGNC:22140,MIM:611061 FAM20C, golgi associated secretory pathway kinase GO:0004674,GO:0005509,GO:0005524,GO:0005615,GO:0005788,GO:0005794,GO:0006468,GO:0030145,GO:0030501,GO:0031214,GO:0036179,GO:0040036,GO:0043687,GO:0044267,GO:0045669,GO:0046034,GO:0051174,GO:0070062,GO:0070166,GO:0071895,GO:0097187 protein serine/threonine kinase activity|calcium ion binding|ATP binding|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|protein phosphorylation|manganese ion binding|positive regulation of bone mineralization|biomineral tissue development|osteoclast maturation|regulation of fibroblast growth factor receptor signaling pathway|post-translational protein modification|cellular protein metabolic process|positive regulation of osteoblast differentiation|ATP metabolic process|regulation of phosphorus metabolic process|extracellular exosome|enamel mineralization|odontoblast differentiation|dentinogenesis FAM210A 333.651523754888 368.786323949594 298.516723560182 0.809457141368898 -0.304973399253209 0.115701734930146 1 2.75388 2.89229 2.14625 2.20139 GeneID:125228,Genbank:NM_152352.3,HGNC:HGNC:28346 family with sequence similarity 210 member A GO:0005739,GO:0016021 mitochondrion|integral component of membrane FAM210B 1230.89979158124 976.905720494593 1484.8938626679 1.51999710055553 0.604068571683241 4.89590614938725e-05 0.0150793909401127 15.1193 15.8212 24.1914 23.2454 GeneID:116151,Genbank:NM_080821.2,HGNC:HGNC:16102 family with sequence similarity 210 member B GO:0005741,GO:0016021,GO:0031224,GO:0043249,GO:0045648,GO:0071392 mitochondrial outer membrane|integral component of membrane|intrinsic component of membrane|erythrocyte maturation|positive regulation of erythrocyte differentiation|cellular response to estradiol stimulus FAM212A 25.6124519416655 32.8053579658194 18.4195459175115 0.561479802680501 -0.83269396735811 0.13927906272491 1 1.47226 1.34371 0.89175 0.568532 GeneID:389119,Genbank:XM_017006372.1,HGNC:HGNC:32480 family with sequence similarity 212 member A GO:0005634,GO:0005737,GO:0019901,GO:0021915,GO:0030291,GO:0070062 nucleus|cytoplasm|protein kinase binding|neural tube development|protein serine/threonine kinase inhibitor activity|extracellular exosome FAM212B 271.165302926835 241.389410752605 300.941195101065 1.24670421193204 0.318119217695919 0.124924476924195 1 1.29228 1.34239 1.56108 1.71413 GeneID:55924,Genbank:NM_198926.2,HGNC:HGNC:28045 family with sequence similarity 212 member B GO:0005634,GO:0019901,GO:0030291 nucleus|protein kinase binding|protein serine/threonine kinase inhibitor activity FAM213B 614.279423398203 664.034545641969 564.524301154437 0.85014297051168 -0.23422261186835 0.224172382292998 1 11.6163 11.1501 8.77015 11.2233 GeneID:127281,Genbank:NM_001195736.2,HGNC:HGNC:28390 family with sequence similarity 213 member B GO:0001516,GO:0005737,GO:0005783,GO:0005829,GO:0016209,GO:0016616,GO:0043209,GO:0047017,GO:0055114,GO:0070062 prostaglandin biosynthetic process|cytoplasm|endoplasmic reticulum|cytosol|antioxidant activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|myelin sheath|prostaglandin-F synthase activity|oxidation-reduction process|extracellular exosome hsa00590 Arachidonic acid metabolism FAM214A 132.844291686844 148.392531241147 117.296052132542 0.790444445899564 -0.339264024386709 0.211533465469808 1 0.946451 0.876493 0.902398 0.642474 GeneID:56204,Genbank:NM_019600.3,HGNC:HGNC:25609 family with sequence similarity 214 member A FAM214B 736.88180469016 714.838275311263 758.925334069057 1.06167417201967 0.0863410707217607 0.609694800384629 1 7.6868 8.26257 8.7777 8.403 GeneID:80256,Genbank:XM_005251591.1,HGNC:HGNC:25666 family with sequence similarity 214 member B GO:0005634 nucleus FAM216A 333.904930765439 364.443324916878 303.366536614001 0.832410736794788 -0.264632521187617 0.167483236491495 1 7.41961 8.018 6.03704 6.26319 GeneID:29902,Genbank:XM_005253875.5,HGNC:HGNC:30180 family with sequence similarity 216 member A FAM217B 130.851992087152 125.042608736572 136.661375437733 1.09291846050364 0.128185769705886 0.628701085401019 1 1.02395 0.9829 1.07229 1.1414 GeneID:63939,Genbank:NM_001190826.1,HGNC:HGNC:16170 family with sequence similarity 217 member B GO:0005654,GO:0005829 nucleoplasm|cytosol FAM218A 4.69095609092421 2.59443583384164 6.78747634800679 2.61616658985026 1.38745441036912 0.349861434833527 1 0.058227 0.0376581 0.187975 0.0698514 GeneID:152756,Genbank:NM_153027.2,HGNC:HGNC:26466 family with sequence similarity 218 member A FAM219A 2011.50332918947 2029.75289098236 1993.25376739658 0.982017947234887 -0.0261787035956983 0.841349286442782 1 18.1827 18.6909 18.6928 18.2314 GeneID:203259,Genbank:NM_001184945.1,HGNC:HGNC:19920 family with sequence similarity 219 member A FAM219B 999.77026539695 921.317963666165 1078.22256712774 1.17030450902879 0.226883962720531 0.142947042412197 1 9.05234 9.84387 10.7036 12.0491 GeneID:57184,Genbank:XM_017022433.2,HGNC:HGNC:24695 family with sequence similarity 219 member B FAM220A 499.515860936705 487.26589936198 511.765822511431 1.05028039758483 0.0707745414162032 0.683429614573978 1 10.778 10.3274 11.3639 10.9878 GeneID:84792,Genbank:NM_001037163.1,HGNC:HGNC:22422,MIM:616628 family with sequence similarity 220 member A GO:0005634 nucleus FAM221A 131.670292454014 143.165441953886 120.175142954143 0.839414465628172 -0.252544769487933 0.348256175832357 1 2.28649 2.18713 1.62319 2.054 GeneID:340277,Genbank:NM_199136.4,HGNC:HGNC:27977 family with sequence similarity 221 member A FAM222A 89.9179746445334 95.5236717603991 84.3122775286677 0.882632293910845 -0.180115561019316 0.577938362145545 1 1.05136 0.937341 0.796942 1.055 GeneID:84915,Genbank:XM_024449229.1,HGNC:HGNC:25915 family with sequence similarity 222 member A FAM222B 606.99389687355 604.746731661091 609.24106208601 1.00743175645212 0.0106821137282393 0.961548963164415 1 2.73168 2.98925 3.29014 2.50949 GeneID:55731,Genbank:NM_001288640.1,HGNC:HGNC:25563 family with sequence similarity 222 member B GO:0005654 nucleoplasm FAM227A 8.60107652715715 9.93569820809413 7.26645484622018 0.731348184499058 -0.451369678509313 0.715637032263181 1 0.0460694 0.0134426 0.0101949 0.0221584 GeneID:646851,Genbank:NM_001013647.1,HGNC:HGNC:44197 family with sequence similarity 227 member A FAM227B 48.1251706164712 57.4814158522114 38.7689253807309 0.674460167794204 -0.568194851747384 0.170844363355405 1 0.120505 0.0984434 0.038963 0.0679878 GeneID:196951,Genbank:XM_017021993.1,HGNC:HGNC:26543 family with sequence similarity 227 member B FAM228A 1.48585272210587 1.51824048055703 1.45346496365472 0.957335140426142 -0.0629040282857778 1 1 0 0.0421673 0.0217728 0.0203186 GeneID:653140,Genbank:NM_001040710.2,HGNC:HGNC:34418 family with sequence similarity 228 member A FAM228B 26.9685128760365 23.888020181217 30.049005570856 1.25791109279468 0.331029958372264 0.541506866434161 1 0.309526 0.184062 0.388833 0.33985 GeneID:375190,Genbank:NM_001291328.1,HGNC:HGNC:24736 family with sequence similarity 228 member B FAM229A 14.326944740158 15.5666150030498 13.0872744772662 0.840727060745201 -0.250290584561762 0.797836338233438 1 1.31858 0.214711 0.716578 0.557242 GeneID:100128071,Genbank:NM_001167676.1,HGNC:HGNC:44652 family with sequence similarity 229 member A FAM229B 320.241248302207 316.331100631649 324.151395972764 1.02472186682087 0.0352323821120737 0.947074097417573 1 3.91458 4.96269 3.53067 5.1585 GeneID:619208,Genbank:NM_001033564.2,HGNC:HGNC:33858 family with sequence similarity 229 member B FAM234A 1940.61607479377 1732.39151320385 2148.84063638369 1.24038972715219 0.310793482782002 0.0297259917518757 0.683058083067491 14.2712 15.7765 19.2997 18.6679 GeneID:83986,Genbank:NM_032039.3,HGNC:HGNC:14163 family with sequence similarity 234 member A GO:0009986,GO:0016021,GO:0070062 cell surface|integral component of membrane|extracellular exosome FAM234B 240.319351541572 293.585902387763 187.052800695381 0.63713141255783 -0.650337126342624 0.00237410811242739 0.17768091368522 2.64743 2.85157 1.65532 1.93076 GeneID:57613,Genbank:NM_020853.1,HGNC:HGNC:29288,MIM:617838 family with sequence similarity 234 member B GO:0016021 integral component of membrane FAM237A 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0894077 0 0 GeneID:200726,Genbank:NM_001102659.2,HGNC:HGNC:52388 family with sequence similarity 237 member A GO:0016021 integral component of membrane FAM241B 298.69821950656 318.281577584371 279.114861428749 0.876943188314946 -0.189444712412493 0.393262281704413 1 6.29767 7.18913 5.17067 6.53219 GeneID:219738,Genbank:XM_005269608.3,HGNC:HGNC:23519 family with sequence similarity 241 member B GO:0016021 integral component of membrane FAM24B 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0.147489 0 0.0715566 GeneID:196792,Genbank:NM_001204364.1,HGNC:HGNC:23475 family with sequence similarity 24 member B GO:0005576 extracellular region FAM32A 2749.46228676537 2358.06520232334 3140.8593712074 1.33196459882144 0.413555738727896 0.00264918873631651 0.187026466830971 47.7706 48.2101 66.3916 64.2125 GeneID:26017,Genbank:XM_011527898.1,HGNC:HGNC:24563,MIM:614554 family with sequence similarity 32 member A GO:0003723,GO:0005634,GO:0005730,GO:0006915,GO:0007049 RNA binding|nucleus|nucleolus|apoptotic process|cell cycle FAM35A 478.894958689279 500.266487495657 457.523429882901 0.914559422465556 -0.128851184387117 0.484421305161888 1 3.78972 3.60144 3.79038 2.90204 GeneID:54537,Genbank:XM_017016350.1,HGNC:HGNC:28773 family with sequence similarity 35 member A FAM3A 1081.26254491352 957.822361783579 1204.70272804346 1.25775172527833 0.330847168592828 0.0290278985697515 0.674846840672015 14.7423 14.4634 18.2725 19.6258 GeneID:60343,Genbank:NM_001282312.1,HGNC:HGNC:13749,MIM:300492 family with sequence similarity 3 member A GO:0005576,GO:0019732,GO:0061844,GO:1905035 extracellular region|antifungal humoral response|antimicrobial humoral immune response mediated by antimicrobial peptide|negative regulation of antifungal innate immune response FAM3B 1.02273099320278 1.07619535328461 0.969266633120943 0.900641904987498 -0.150974490057726 1 1 0.0506458 0 0.0238771 0.0222087 GeneID:54097,Genbank:XM_011529649.2,HGNC:HGNC:1253,MIM:608617 family with sequence similarity 3 member B GO:0005125,GO:0005576,GO:0006915,GO:0030073,GO:0070062 cytokine activity|extracellular region|apoptotic process|insulin secretion|extracellular exosome FAM3C 1965.14182652098 1861.76426131546 2068.5193917265 1.1110533351118 0.151928073661657 0.270443463452053 1 24.6347 22.7281 30.5412 25.1425 GeneID:10447,Genbank:XM_011515736.2,HGNC:HGNC:18664,MIM:608618 family with sequence similarity 3 member C GO:0002576,GO:0005125,GO:0005576,GO:0005794,GO:0007275,GO:0031089,GO:0070062 platelet degranulation|cytokine activity|extracellular region|Golgi apparatus|multicellular organism development|platelet dense granule lumen|extracellular exosome FAM43A 133.104936780131 131.47137189181 134.738501668452 1.02485050341857 0.0354134768462914 0.921241068274741 1 2.61805 2.82588 3.17724 2.56727 GeneID:131583,Genbank:NM_153690.4,HGNC:HGNC:26888 family with sequence similarity 43 member A FAM43B 1.99243261235042 1.07619535328461 2.90866987141623 2.70273409241064 1.43441957978558 0.610209176940818 1 0.0485174 0 0.0889234 0.0415559 GeneID:163933,Genbank:NM_207334.2,HGNC:HGNC:31791 family with sequence similarity 43 member B FAM45A 366.674198070085 383.449231387883 349.899164752287 0.912504540655453 -0.132096357087009 0.504408808838089 1 4.4745 4.30073 4.1694 4.00339 GeneID:404636,Genbank:NM_001303111.1,HGNC:HGNC:31793 family with sequence similarity 45 member A FAM46A 510.113451429012 439.960313091287 580.266589766736 1.31890666612544 0.399342474307224 0.437164610002615 1 3.57367 3.47064 6.33049 3.10782 GeneID:55603,Genbank:NM_017633.2,HGNC:HGNC:18345,MIM:611357 family with sequence similarity 46 member A GO:0003723,GO:0016779 RNA binding|nucleotidyltransferase activity FAM46B 58.5587913096506 50.2460146824368 66.8715679368645 1.3308830234498 0.412383772673387 0.296689364894601 1 0.807198 1.24101 1.22454 1.56449 GeneID:115572,Genbank:NM_052943.3,HGNC:HGNC:28273 family with sequence similarity 46 member B GO:0016779 nucleotidyltransferase activity FAM46C 17.7480675732424 16.1047126796921 19.3914224667926 1.20408372707233 0.267935714715739 0.712647032764096 1 0.158386 0.0938343 0.215128 0.0966206 GeneID:54855,Genbank:NM_017709.3,HGNC:HGNC:24712,MIM:613952 family with sequence similarity 46 member C GO:0016779 nucleotidyltransferase activity FAM47E 4.67901571598053 4.99676656894351 4.36126486301754 0.872817411588565 -0.19624821302199 0.947218890387232 1 0.0718627 0.261691 0.197976 0.301723 GeneID:100129583,Genbank:NM_001242936.1,HGNC:HGNC:34343 family with sequence similarity 47 member E GO:0005737 cytoplasm FAM49A 32.7945538595293 25.8483057890465 39.7408019300121 1.53746254220084 0.620551261938454 0.207108862754935 1 0.185055 0.154949 0.244625 0.248985 GeneID:81553,Genbank:NM_030797.3,HGNC:HGNC:25373 family with sequence similarity 49 member A GO:0005622 intracellular FAM49B 1624.62887890727 1724.5865543904 1524.67120342415 0.884079259195597 -0.177752379430626 0.217807884089661 1 11.8365 11.7584 10.9426 9.72376 GeneID:51571,Genbank:NM_001353269.1,HGNC:HGNC:25216 family with sequence similarity 49 member B GO:0001916,GO:0002576,GO:0005576,GO:0005929,GO:0016020,GO:0023030,GO:0031093,GO:0032729,GO:0050870,GO:0070062,GO:2000568 positive regulation of T cell mediated cytotoxicity|platelet degranulation|extracellular region|cilium|membrane|MHC class Ib protein binding, via antigen binding groove|platelet alpha granule lumen|positive regulation of interferon-gamma production|positive regulation of T cell activation|extracellular exosome|positive regulation of memory T cell activation FAM50A 3461.95611043122 3411.50830541754 3512.40391544489 1.02957507383673 0.0420490312358994 0.767960053822605 1 72.6561 75.6298 74.3397 78.8656 GeneID:9130,Genbank:NM_004699.3,HGNC:HGNC:18786,MIM:300453 family with sequence similarity 50 member A GO:0003723,GO:0005634,GO:0005654,GO:0007283 RNA binding|nucleus|nucleoplasm|spermatogenesis FAM53A 6.40609763129989 6.51500704950053 6.29718821309924 0.966566600044125 -0.049058951956233 1 1 0.026854 0.0476872 0.0166959 0.0389742 GeneID:152877,Genbank:XM_011513404.2,HGNC:HGNC:31860,MIM:617229 family with sequence similarity 53 member A GO:0005634 nucleus FAM53B 1856.48265605013 1845.64399932897 1867.32131277129 1.01174512172997 0.0168458928690175 0.93046219951312 1 14.42 15.5346 16.2676 14.7439 GeneID:9679,Genbank:NM_014661.3,HGNC:HGNC:28968,MIM:617289 family with sequence similarity 53 member B GO:0005634,GO:0016055,GO:0035411,GO:0090263 nucleus|Wnt signaling pathway|catenin import into nucleus|positive regulation of canonical Wnt signaling pathway FAM53C 1921.12125241637 1873.72113106374 1968.521373769 1.05059463819541 0.0712061266996537 0.629521220196533 1 16.9423 18.2225 19.0024 18.9461 GeneID:51307,Genbank:NM_001135647.1,HGNC:HGNC:1336,MIM:609372 family with sequence similarity 53 member C FAM57A 1522.78784577782 1663.37972342383 1382.1959681318 0.830956364723952 -0.267155374870341 0.0589900257015508 0.879410748501007 35.3994 41.8448 33.2122 30.6377 GeneID:79850,Genbank:NM_024792.2,HGNC:HGNC:29646,MIM:611627 family with sequence similarity 57 member A FAM57B 10.3407745573771 13.4142242964806 7.26732481827358 0.541762584078772 -0.884267335212282 0.346033132435285 1 0.0583752 0.0926983 0.0543843 0.0305677 GeneID:83723,Genbank:NM_001352173.1,HGNC:HGNC:25295,MIM:615175 family with sequence similarity 57 member B GO:0000139,GO:0005783,GO:0005789,GO:0016021,GO:0045599,GO:0046513,GO:0050291 Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|negative regulation of fat cell differentiation|ceramide biosynthetic process|sphingosine N-acyltransferase activity FAM69A 385.414819215261 407.3372515691 363.492386861422 0.892362251331584 -0.164298608836221 0.396826749632259 1 4.8338 4.52403 4.63509 3.87835 GeneID:388650,Genbank:NM_001252273.1,HGNC:HGNC:32213,MIM:614542 family with sequence similarity 69 member A GO:0005789,GO:0016021 endoplasmic reticulum membrane|integral component of membrane FAM69B 26.7598038287293 30.2589484066627 23.2606592507958 0.76872001426441 -0.379469864170245 0.504344594325855 1 0.203974 0.216319 0.220889 0.206572 GeneID:138311,Genbank:NM_152421.3,HGNC:HGNC:28290,MIM:614543 family with sequence similarity 69 member B GO:0005789,GO:0016021 endoplasmic reticulum membrane|integral component of membrane FAM69C 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0414126 GeneID:125704,Genbank:XM_017025551.2,HGNC:HGNC:31729,MIM:614544 family with sequence similarity 69 member C GO:0005789,GO:0016021 endoplasmic reticulum membrane|integral component of membrane FAM71A 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0140277 0 0 GeneID:149647,Genbank:NM_153606.3,HGNC:HGNC:26541 family with sequence similarity 71 member A GO:0005634 nucleus FAM71E1 86.149971523636 81.1871395897966 91.1128034574754 1.12225660268152 0.166402584226603 0.627157799403968 1 0.431289 0.334986 0.467944 0.709133 GeneID:112703,Genbank:XM_011526405.2,HGNC:HGNC:25107 family with sequence similarity 71 member E1 GO:0005634 nucleus FAM71F1 0.998282869833606 1.02816907859967 0.968396661067546 0.941865186596032 -0.0864075197076174 1 1 0.012516 0.0116422 0 0.0221782 GeneID:84691,Genbank:NM_001282789.1,HGNC:HGNC:30704 family with sequence similarity 71 member F1 GO:0005634 nucleus FAM71F2 22.2150885857986 23.10979113115 21.3203860404472 0.922569395779138 -0.116270659940971 0.886755177675913 1 0.122168 0.0983302 0.0634014 0.11346 GeneID:346653,Genbank:XM_011516136.2,HGNC:HGNC:27998 family with sequence similarity 71 member F2 GO:0005634 nucleus FAM72A 109.689932563292 127.781123394468 91.598741732116 0.716840948794486 -0.480275042682472 0.0987612576300736 1 0.883827 0.686697 0.558522 0.48325 GeneID:729533,Genbank:NM_001317901.1,HGNC:HGNC:24044,MIM:614710 family with sequence similarity 72 member A GO:0005739,GO:0005829,GO:0043231 mitochondrion|cytosol|intracellular membrane-bounded organelle FAM72B 622.823469728806 708.658435183703 536.98850427391 0.757753633645395 -0.400199229725832 0.0167307491417136 0.538071643079688 5.06241 4.70053 3.86818 3.60032 GeneID:653820,Genbank:XM_011542018.1,HGNC:HGNC:24805,MIM:614711 family with sequence similarity 72 member B GO:0005829,GO:0043231 cytosol|intracellular membrane-bounded organelle FAM72C 48.867722940434 46.8537324883122 50.8817133925558 1.08596926414023 0.118983271558516 0.783135970624604 1 0.439623 0.44237 0.434772 0.630693 GeneID:554282,Genbank:NM_001346067.1,HGNC:HGNC:30602,MIM:616853 family with sequence similarity 72 member C GO:0005829,GO:0043231 cytosol|intracellular membrane-bounded organelle FAM72D 91.2547841617987 110.302249058274 72.2073192653233 0.654631432104121 -0.611245219892316 0.0511515407466405 0.82804521131659 0.891639 0.797038 0.62694 0.682668 GeneID:728833,Genbank:XM_011509962.3,HGNC:HGNC:33593,MIM:614712 family with sequence similarity 72 member D GO:0005829,GO:0043231 cytosol|intracellular membrane-bounded organelle FAM76A 132.094948006161 144.971840082553 119.218055929769 0.822353195364572 -0.282169939714752 0.297458921055266 1 1.01846 0.959336 0.869949 0.747525 GeneID:199870,Genbank:NM_001143912.1,HGNC:HGNC:28530 family with sequence similarity 76 member A GO:0005654 nucleoplasm FAM76B 86.5417121825605 93.1115323701893 79.9718919949317 0.858882782392437 -0.219466844548489 0.523288278271636 1 0.825464 0.697696 0.687184 0.538128 GeneID:143684,Genbank:NM_001330357.1,HGNC:HGNC:28492 family with sequence similarity 76 member B GO:0016607 nuclear speck FAM78A 8.60204195949084 4.60274771635603 12.6013362026257 2.73778555314826 1.45300944676896 0.159002850094349 1 0.0183201 0.040299 0.110656 0.087674 GeneID:286336,Genbank:XM_011518568.3,HGNC:HGNC:25465 family with sequence similarity 78 member A FAM78B 28.6828928108339 27.3185199949186 30.0472656267492 1.09988629077777 0.137354381740319 0.81550088910533 1 0.106946 0.0857243 0.112887 0.105461 GeneID:149297,Genbank:NM_001320302.1,HGNC:HGNC:13495 family with sequence similarity 78 member B FAM81A 133.198899639786 154.917346945755 111.480452333816 0.71961245484569 -0.474707938330467 0.0733923964106842 0.934750619674839 1.24492 1.22334 1.11446 0.76756 GeneID:145773,Genbank:XM_011521248.2,HGNC:HGNC:28379 family with sequence similarity 81 member A FAM83C 1.22224196918161 1.96028560782945 0.484198330533773 0.247003971564076 -2.01739385587201 0.637784766456736 1 0 0.0444949 0 0.011041 GeneID:128876,Genbank:NM_178468.5,HGNC:HGNC:16121 family with sequence similarity 83 member C GO:0019901 protein kinase binding FAM83D 2424.52214972658 2495.63794510185 2353.4063543513 0.943007922671756 -0.0846582031479249 0.538578649270478 1 35.4655 35.7713 35.4923 32.4566 GeneID:81610,Genbank:NM_030919.2,HGNC:HGNC:16122 family with sequence similarity 83 member D GO:0001837,GO:0005737,GO:0008017,GO:0008283,GO:0016477,GO:0019894,GO:0019901,GO:0032006,GO:0042176,GO:0051301,GO:0051310,GO:0070372,GO:0097431,GO:1902480,GO:1902808 epithelial to mesenchymal transition|cytoplasm|microtubule binding|cell proliferation|cell migration|kinesin binding|protein kinase binding|regulation of TOR signaling|regulation of protein catabolic process|cell division|metaphase plate congression|regulation of ERK1 and ERK2 cascade|mitotic spindle pole|protein localization to mitotic spindle|positive regulation of cell cycle G1/S phase transition FAM83E 3.07906915040211 5.18887166768327 0.969266633120943 0.186797187364956 -2.42045536256559 0.23609830661954 1 0.0722369 0.0248919 0 0.0124936 GeneID:54854,Genbank:NM_017708.3,HGNC:HGNC:25972 family with sequence similarity 83 member E GO:0019901 protein kinase binding FAM83G 1409.15160618606 1392.54679393335 1425.75641843877 1.02384812104706 0.0340017199635767 0.833077813601633 1 9.7889 10.2489 10.5943 10.5437 GeneID:644815,Genbank:XM_017024953.2,HGNC:HGNC:32554,MIM:615886 family with sequence similarity 83 member G GO:0005634,GO:0005829,GO:0030509 nucleus|cytosol|BMP signaling pathway FAM83H 0.972638154859436 0.490071401957362 1.45520490776151 2.96937324224464 1.5701584476161 0.837389832160054 1 0 0.00416845 0.00451207 0 GeneID:286077,Genbank:XM_024447131.1,HGNC:HGNC:24797,MIM:611927 family with sequence similarity 83 member H GO:0005737,GO:0005856,GO:0019901,GO:0030335,GO:0031214,GO:0044380,GO:0045104,GO:1990254 cytoplasm|cytoskeleton|protein kinase binding|positive regulation of cell migration|biomineral tissue development|protein localization to cytoskeleton|intermediate filament cytoskeleton organization|keratin filament binding FAM84A 193.568339271631 178.71912323271 208.417555310551 1.16617377894793 0.221782789692374 0.345585157297108 1 1.24405 1.31397 1.77586 1.25681 GeneID:151354,Genbank:NM_145175.3,HGNC:HGNC:20743,MIM:611234 family with sequence similarity 84 member A FAM84B 2964.86870688757 2967.06563812032 2962.67177565481 0.998519121919967 -0.00213803894074151 0.997516271345212 1 27.3302 25.5069 28.8156 24.8332 GeneID:157638,Genbank:NM_174911.4,HGNC:HGNC:24166,MIM:609483 family with sequence similarity 84 member B GO:0005737,GO:0005886 cytoplasm|plasma membrane FAM86B1 20.8531080581703 22.3217534259751 19.3844626903655 0.868411290118832 -0.203549612494222 0.799219049984395 1 0.221196 0.125165 0.103133 0.131785 GeneID:85002,Genbank:NM_001083537.1,HGNC:HGNC:28268,MIM:616122 family with sequence similarity 86 member B1 GO:0008168 methyltransferase activity FAM86B2 2.02395039874818 2.59443583384164 1.45346496365472 0.560223900971387 -0.835924560105201 0.824517683088342 1 0 0.0290355 0 0.0843591 GeneID:653333,Genbank:NM_001137610.2,HGNC:HGNC:32222,MIM:616123 family with sequence similarity 86 member B2 GO:0008168,GO:0043234 methyltransferase activity|protein complex FAM86C1 120.594552775815 131.673285645658 109.515819905972 0.831723909439664 -0.265823389339648 0.325428067631419 1 1.73603 2.16096 1.43274 1.60205 GeneID:55199,Genbank:NM_001099653.1,HGNC:HGNC:25561,MIM:616124 family with sequence similarity 86 member C1 GO:0008168,GO:0043234 methyltransferase activity|protein complex FAM89A 139.601894460996 149.824527827442 129.379261094551 0.863538587243619 -0.211667448828365 0.422686472043468 1 6.07964 5.85582 4.53998 5.79334 GeneID:375061,Genbank:NM_198552.2,HGNC:HGNC:25057 family with sequence similarity 89 member A FAM89B 915.759383331421 877.798678442184 953.720088220658 1.0864906858976 0.119675806855197 0.456615236529522 1 37.9365 39.3863 41.2915 44.009 GeneID:23625,Genbank:NM_001098784.1,HGNC:HGNC:16708,MIM:616128 family with sequence similarity 89 member B GO:0001222,GO:0005737,GO:0030010,GO:0030027,GO:0030335,GO:0030512,GO:0060392 transcription corepressor binding|cytoplasm|establishment of cell polarity|lamellipodium|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of SMAD protein import into nucleus FAM8A1 497.104664124055 503.23532487187 490.974003376241 0.975635014297234 -0.0355865593378182 0.898196222484994 1 5.58368 4.71442 5.72057 4.43635 GeneID:51439,Genbank:NM_016255.2,HGNC:HGNC:16372 family with sequence similarity 8 member A1 GO:0016021 integral component of membrane FAM90A1 0.998282869833606 1.02816907859967 0.968396661067546 0.941865186596032 -0.0864075197076174 1 1 0.0133405 0.0118105 0 0.0116343 GeneID:55138,Genbank:NM_001319982.1,HGNC:HGNC:25526,MIM:613041 family with sequence similarity 90 member A1 FAM91A1 1105.24143544067 1208.60530506422 1001.87756581712 0.828953473577452 -0.270636964605123 0.437016416261896 1 10.1009 7.6538 8.90007 5.8713 GeneID:157769,Genbank:NM_001317917.1,HGNC:HGNC:26306 family with sequence similarity 91 member A1 GO:0005802 trans-Golgi network FAM92A 204.561589653299 218.654021163826 190.469158142773 0.8710983549672 -0.199092473408304 0.393090815867192 1 1.21373 1.21572 1.11926 0.993458 GeneID:137392,Genbank:XM_005250787.2,HGNC:HGNC:30452,MIM:617273 family with sequence similarity 92 member A GO:0005634,GO:0005737,GO:0005814,GO:0036064,GO:0060271,GO:0097546 nucleus|cytoplasm|centriole|ciliary basal body|cilium assembly|ciliary base FAM92B 1.99536914806221 1.56626675524197 2.42447154088245 1.54793015478893 0.630340376125113 0.890462484667886 1 0.048216 0 0.0453522 0 GeneID:339145,Genbank:XM_005255931.2,HGNC:HGNC:24781,MIM:617274 family with sequence similarity 92 member B GO:0005814,GO:0030030,GO:0042995 centriole|cell projection organization|cell projection FAM96A 1595.80307191978 1681.64358446264 1509.96255937692 0.897908791927171 -0.155359189027006 0.326569473108307 1 14.5762 15.8709 12.4959 14.9588 GeneID:84191,Genbank:NM_001014812.2,HGNC:HGNC:26235 family with sequence similarity 96 member A GO:0005634,GO:0005654,GO:0005829,GO:0007059,GO:0046872 nucleus|nucleoplasm|cytosol|chromosome segregation|metal ion binding FAM96B 1401.50305071214 1464.1256275836 1338.88047384068 0.914457372111145 -0.129012175298539 0.534674522366037 1 57.6155 56.5119 46.9432 55.5301 GeneID:51647,Genbank:NM_016062.3,HGNC:HGNC:24261,MIM:614778 family with sequence similarity 96 member B GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0007059,GO:0016226,GO:0071817,GO:0097361 nucleus|nucleoplasm|cytoplasm|spindle|cytosol|chromosome segregation|iron-sulfur cluster assembly|MMXD complex|CIA complex FAM98A 1505.16929424463 1521.98921963158 1488.34936885769 0.977897444778202 -0.032244921803859 0.828366949433419 1 20.0679 19.9503 20.972 18.363 GeneID:25940,Genbank:NM_001304538.1,HGNC:HGNC:24520 family with sequence similarity 98 member A GO:0003723,GO:0006479,GO:0008276,GO:0008284,GO:0010628,GO:0032418,GO:0072669,GO:1900029 RNA binding|protein methylation|protein methyltransferase activity|positive regulation of cell proliferation|positive regulation of gene expression|lysosome localization|tRNA-splicing ligase complex|positive regulation of ruffle assembly FAM98B 1135.36594865285 1257.31447895674 1013.41741834896 0.806017456499707 -0.311117010311739 0.14947323810099 1 12.986 10.9086 10.4859 8.78368 GeneID:283742,Genbank:NM_173611.3,HGNC:HGNC:26773,MIM:616142 family with sequence similarity 98 member B GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0006388,GO:0006479,GO:0008276,GO:0008284,GO:0010628,GO:0042802,GO:0043231,GO:0072669 RNA binding|nucleus|nucleoplasm|cytoplasm|tRNA splicing, via endonucleolytic cleavage and ligation|protein methylation|protein methyltransferase activity|positive regulation of cell proliferation|positive regulation of gene expression|identical protein binding|intracellular membrane-bounded organelle|tRNA-splicing ligase complex FAM98C 290.66559788309 291.54918154078 289.7820142254 0.99393869910373 -0.00877121817646548 0.951431697295398 1 6.93089 7.52578 6.45116 7.86934 GeneID:147965,Genbank:XM_017026354.1,HGNC:HGNC:27119 family with sequence similarity 98 member C GO:0072669 tRNA-splicing ligase complex FAN1 861.635190751343 849.949835424022 873.320546078664 1.02749657648087 0.0391335869947491 0.788486679832039 1 5.01913 4.62149 5.23201 4.79393 GeneID:22909,Genbank:NM_001146095.1,HGNC:HGNC:29170,MIM:613534 FANCD2 and FANCI associated nuclease 1 GO:0000287,GO:0000724,GO:0004528,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006289,GO:0008409,GO:0017108,GO:0033683,GO:0036297,GO:0045171,GO:0070336,GO:0140036 magnesium ion binding|double-strand break repair via homologous recombination|phosphodiesterase I activity|nucleus|nucleoplasm|cytosol|DNA repair|nucleotide-excision repair|5'-3' exonuclease activity|5'-flap endonuclease activity|nucleotide-excision repair, DNA incision|interstrand cross-link repair|intercellular bridge|flap-structured DNA binding|ubiquitin-dependent protein binding hsa03460 Fanconi anemia pathway FANCA 1196.89387568854 1209.33957584302 1184.44817553406 0.979417360676709 -0.0300043261020527 0.838056787985564 1 5.47326 5.1736 5.55994 5.0888 GeneID:2175,Genbank:NM_000135.3,HGNC:HGNC:3582,MIM:607139 Fanconi anemia complementation group A hsa03460 Fanconi anemia pathway FANCB 58.2908453940638 59.8739379322054 56.7077528559222 0.947119144228192 -0.0783821718597949 0.876897724986352 1 0.262446 0.235072 0.275078 0.202667 GeneID:2187,Genbank:XM_011545470.2,HGNC:HGNC:3583,MIM:300515 Fanconi anemia complementation group B hsa03460 Fanconi anemia pathway FANCC 587.525186732353 579.474741168263 595.575632296443 1.02778532002227 0.0395389512211413 0.820607152996886 1 2.36117 2.49942 2.37189 2.66244 GeneID:2176,Genbank:NM_000136.2,HGNC:HGNC:3584,MIM:613899 Fanconi anemia complementation group C hsa03460 Fanconi anemia pathway FANCD2 1427.41331576508 1521.57558346878 1333.25104806138 0.876230574771666 -0.190617538635683 0.194238817718586 1 7.99027 7.99235 7.42617 6.61025 GeneID:2177,Genbank:NM_001018115.2,HGNC:HGNC:3585,MIM:613984 Fanconi anemia complementation group D2 hsa03460 Fanconi anemia pathway FANCD2OS 6.48357512872419 7.63922867747008 5.32792157997829 0.697442347247912 -0.51985413067271 0.696042256717118 1 0 0 0 0 GeneID:115795,Genbank:NM_173472.1,HGNC:HGNC:28623 FANCD2 opposite strand FANCE 667.200175376247 682.599423986555 651.800926765938 0.954880569572201 -0.0666077936349659 0.681609140269546 1 10.1022 10.2334 9.59338 10.2735 GeneID:2178,Genbank:XM_005248887.2,HGNC:HGNC:3586,MIM:613976 Fanconi anemia complementation group E hsa03460 Fanconi anemia pathway FANCF 212.491606604483 233.548268321287 191.43494488768 0.819680429504736 -0.286866542023593 0.201522127691725 1 3.90386 3.94206 3.41903 3.01662 GeneID:2188,Genbank:NM_022725.3,HGNC:HGNC:3587,MIM:613897 Fanconi anemia complementation group F hsa03460 Fanconi anemia pathway FANCG 1159.97728566062 1159.29649191528 1160.65807940595 1.00117449461821 0.00169344328578836 0.991604396669859 1 15.2465 16.4503 16.3035 16.0878 GeneID:2189,Genbank:NM_004629.1,HGNC:HGNC:3588,MIM:602956 Fanconi anemia complementation group G hsa03460 Fanconi anemia pathway FANCI 2631.65253468195 2692.60029506229 2570.70477430161 0.954729440910997 -0.0668361466173169 0.723824361823268 1 19.9752 17.6441 20.5773 15.8815 GeneID:55215,Genbank:XM_011521757.2,HGNC:HGNC:25568,MIM:611360 Fanconi anemia complementation group I hsa03460 Fanconi anemia pathway FANCL 317.702060865367 339.776058684739 295.628063045994 0.870067373758939 -0.200800974357637 0.322029035451695 1 5.29322 4.68532 4.49493 4.0623 GeneID:55120,Genbank:NM_018062.3,HGNC:HGNC:20748,MIM:608111 Fanconi anemia complementation group L hsa03460,hsa04120 Fanconi anemia pathway|Ubiquitin mediated proteolysis FANCM 37.5621639976581 38.2921959367203 36.8321320585958 0.961870458394778 -0.0560854853158314 0.922048476023087 1 0.150042 0.166073 0.159995 0.157731 GeneID:57697,Genbank:NM_020937.3,HGNC:HGNC:23168,MIM:609644 Fanconi anemia complementation group M hsa03460 Fanconi anemia pathway FANK1 34.5782903307673 38.1383084575575 31.018272203977 0.813310119364519 -0.29812253058337 0.563227414182409 1 0.25224 0.211136 0.137765 0.159859 GeneID:92565,Genbank:XM_011540349.3,HGNC:HGNC:23527,MIM:611640 fibronectin type III and ankyrin repeat domains 1 GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0043065,GO:0043066,GO:0045893,GO:0051091 nucleus|nucleoplasm|cytoplasm|cytosol|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|positive regulation of DNA binding transcription factor activity FAP 7.10176021895099 9.83964565872424 4.36387477917774 0.443499179801108 -1.17299665845114 0.313977646770471 1 0.0413239 0.026892 0.0267473 0 GeneID:2191,Genbank:NM_001291807.2,HGNC:HGNC:3590,MIM:600403 fibroblast activation protein alpha GO:0001525,GO:0002020,GO:0004175,GO:0004222,GO:0004252,GO:0005178,GO:0005615,GO:0005737,GO:0005886,GO:0005925,GO:0006508,GO:0007155,GO:0008233,GO:0008236,GO:0008239,GO:0009986,GO:0010710,GO:0010716,GO:0016021,GO:0030027,GO:0031258,GO:0032587,GO:0042803,GO:0043542,GO:0045177,GO:0045178,GO:0046983,GO:0051603,GO:0051917,GO:0060244,GO:0071158,GO:0071438,GO:0071850,GO:0097325,GO:1900119,GO:1902362,GO:1903054 angiogenesis|protease binding|endopeptidase activity|metalloendopeptidase activity|serine-type endopeptidase activity|integrin binding|extracellular space|cytoplasm|plasma membrane|focal adhesion|proteolysis|cell adhesion|peptidase activity|serine-type peptidase activity|dipeptidyl-peptidase activity|cell surface|regulation of collagen catabolic process|negative regulation of extracellular matrix disassembly|integral component of membrane|lamellipodium|lamellipodium membrane|ruffle membrane|protein homodimerization activity|endothelial cell migration|apical part of cell|basal part of cell|protein dimerization activity|proteolysis involved in cellular protein catabolic process|regulation of fibrinolysis|negative regulation of cell proliferation involved in contact inhibition|positive regulation of cell cycle arrest|invadopodium membrane|mitotic cell cycle arrest|melanocyte proliferation|positive regulation of execution phase of apoptosis|melanocyte apoptotic process|negative regulation of extracellular matrix organization FAR1 319.066341178618 353.602902143169 284.529780214067 0.804659063852551 -0.31355045585528 0.41557099346968 1 3.06147 2.35544 2.68202 1.65013 GeneID:84188,Genbank:NM_032228.5,HGNC:HGNC:26222,MIM:616107 fatty acyl-CoA reductase 1 GO:0005777,GO:0005778,GO:0005779,GO:0005782,GO:0008611,GO:0010025,GO:0016491,GO:0035336,GO:0046474,GO:0080019,GO:0102965 peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|peroxisomal matrix|ether lipid biosynthetic process|wax biosynthetic process|oxidoreductase activity|long-chain fatty-acyl-CoA metabolic process|glycerophospholipid biosynthetic process|fatty-acyl-CoA reductase (alcohol-forming) activity|alcohol-forming fatty acyl-CoA reductase activity hsa04146 Peroxisome FAR2 178.24921920387 175.230788489216 181.267649918524 1.0344509174521 0.0488651939380443 0.840375927542332 1 0.969668 0.96751 1.23233 0.921052 GeneID:55711,Genbank:NM_001271783.1,HGNC:HGNC:25531,MIM:616156 fatty acyl-CoA reductase 2 GO:0005777,GO:0005779,GO:0005782,GO:0006629,GO:0010025,GO:0016491,GO:0035336,GO:0080019,GO:0102965 peroxisome|integral component of peroxisomal membrane|peroxisomal matrix|lipid metabolic process|wax biosynthetic process|oxidoreductase activity|long-chain fatty-acyl-CoA metabolic process|fatty-acyl-CoA reductase (alcohol-forming) activity|alcohol-forming fatty acyl-CoA reductase activity hsa04146 Peroxisome FARP1 1337.31478499047 1292.46840073128 1382.16116924966 1.06939648850806 0.0967968445943308 0.524524835571175 1 6.45552 6.96182 7.33848 6.97351 GeneID:10160,Genbank:NM_001286839.1,HGNC:HGNC:3591,MIM:602654 FERM, ARH/RhoGEF and pleckstrin domain protein 1 GO:0005089,GO:0005829,GO:0005856,GO:0007416,GO:0008092,GO:0010923,GO:0030054,GO:0030175,GO:0030425,GO:0030676,GO:0031234,GO:0035023,GO:0043197,GO:0048813 Rho guanyl-nucleotide exchange factor activity|cytosol|cytoskeleton|synapse assembly|cytoskeletal protein binding|negative regulation of phosphatase activity|cell junction|filopodium|dendrite|Rac guanyl-nucleotide exchange factor activity|extrinsic component of cytoplasmic side of plasma membrane|regulation of Rho protein signal transduction|dendritic spine|dendrite morphogenesis FARP2 199.318066628588 205.249605522454 193.386527734723 0.94220170237339 -0.0858921562126372 0.716658866962719 1 0.892116 0.889762 0.977884 0.871331 GeneID:9855,Genbank:NM_014808.3,HGNC:HGNC:16460,MIM:617586 FERM, ARH/RhoGEF and pleckstrin domain protein 2 GO:0005089,GO:0005737,GO:0005829,GO:0005856,GO:0007155,GO:0008092,GO:0016322,GO:0016601,GO:0022405,GO:0030316,GO:0030676,GO:0031532,GO:0033623,GO:0035023,GO:0071526,GO:0071800 Rho guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|cytoskeleton|cell adhesion|cytoskeletal protein binding|neuron remodeling|Rac protein signal transduction|hair cycle process|osteoclast differentiation|Rac guanyl-nucleotide exchange factor activity|actin cytoskeleton reorganization|regulation of integrin activation|regulation of Rho protein signal transduction|semaphorin-plexin signaling pathway|podosome assembly hsa04015,hsa04520 Rap1 signaling pathway|Adherens junction FARS2 393.479360009488 381.826146703703 405.132573315273 1.06103936781903 0.0854781856623127 0.661831541680546 1 1.42053 1.60611 1.53426 1.58152 GeneID:10667,Genbank:XM_017010186.1,HGNC:HGNC:21062,MIM:611592 phenylalanyl-tRNA synthetase 2, mitochondrial GO:0000049,GO:0004826,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006432,GO:0008033 tRNA binding|phenylalanine-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|phenylalanyl-tRNA aminoacylation|tRNA processing hsa00970 Aminoacyl-tRNA biosynthesis FARSA 3419.40834163036 3713.19713292198 3125.61955033875 0.841759658442684 -0.248519725098271 0.117228710369543 1 60.3631 64.1554 49.2156 55.3225 GeneID:2193,Genbank:NM_004461.2,HGNC:HGNC:3592,MIM:602918 phenylalanyl-tRNA synthetase alpha subunit GO:0000049,GO:0003723,GO:0004826,GO:0005524,GO:0005737,GO:0005829,GO:0006418,GO:0006432,GO:0009328,GO:0016020,GO:0051290 tRNA binding|RNA binding|phenylalanine-tRNA ligase activity|ATP binding|cytoplasm|cytosol|tRNA aminoacylation for protein translation|phenylalanyl-tRNA aminoacylation|phenylalanine-tRNA ligase complex|membrane|protein heterotetramerization hsa00970 Aminoacyl-tRNA biosynthesis FARSB 1329.87607742223 1430.71249435453 1229.03966048994 0.859040279119413 -0.219202316115649 0.137443554925783 1 9.35848 9.65444 8.92385 7.842 GeneID:10056,Genbank:NM_005687.4,HGNC:HGNC:17800,MIM:609690 phenylalanyl-tRNA synthetase beta subunit GO:0000287,GO:0003723,GO:0004826,GO:0005524,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006432,GO:0009328,GO:0016020,GO:0051290 magnesium ion binding|RNA binding|phenylalanine-tRNA ligase activity|ATP binding|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|phenylalanyl-tRNA aminoacylation|phenylalanine-tRNA ligase complex|membrane|protein heterotetramerization hsa00970 Aminoacyl-tRNA biosynthesis FAS 195.340665528978 235.575180513163 155.106150544793 0.658414652201131 -0.602931653382531 0.0741492041549689 0.938051859199038 0.977297 0.839525 0.759353 0.498146 GeneID:355,Genbank:XM_006717819.3,HGNC:HGNC:11920,MIM:134637 Fas cell surface death receptor hsa01524,hsa04010,hsa04060,hsa04115,hsa04210,hsa04217,hsa04650,hsa04668,hsa04932,hsa04940,hsa05010,hsa05142,hsa05143,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05205,hsa05320,hsa05330,hsa05332 Platinum drug resistance|MAPK signaling pathway|Cytokine-cytokine receptor interaction|p53 signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|TNF signaling pathway|Non-alcoholic fatty liver disease (NAFLD)|Type I diabetes mellitus|Alzheimer disease|Chagas disease (American trypanosomiasis)|African trypanosomiasis|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease FASN 9522.82070961946 10446.0220054875 8599.61941375136 0.823243470981947 -0.280608929815077 0.0297892371887691 0.683530691712502 52.1561 51.1909 43.9695 42.8162 GeneID:2194,Genbank:XM_011523538.2,HGNC:HGNC:3594,MIM:600212 fatty acid synthase GO:0001649,GO:0003723,GO:0004312,GO:0004313,GO:0004314,GO:0004315,GO:0004316,GO:0004317,GO:0004319,GO:0004320,GO:0005739,GO:0005794,GO:0005829,GO:0005886,GO:0006084,GO:0006631,GO:0006633,GO:0008144,GO:0015939,GO:0016020,GO:0016295,GO:0016296,GO:0030879,GO:0031177,GO:0031325,GO:0042470,GO:0042587,GO:0042803,GO:0045296,GO:0045540,GO:0046949,GO:0047117,GO:0047451,GO:0070062,GO:0070402,GO:0071353,GO:0102131,GO:0102132 osteoblast differentiation|RNA binding|fatty acid synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|oleoyl-[acyl-carrier-protein] hydrolase activity|mitochondrion|Golgi apparatus|cytosol|plasma membrane|acetyl-CoA metabolic process|fatty acid metabolic process|fatty acid biosynthetic process|drug binding|pantothenate metabolic process|membrane|myristoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|mammary gland development|phosphopantetheine binding|positive regulation of cellular metabolic process|melanosome|glycogen granule|protein homodimerization activity|cadherin binding|regulation of cholesterol biosynthetic process|fatty-acyl-CoA biosynthetic process|enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity|3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity|extracellular exosome|NADPH binding|cellular response to interleukin-4|3-oxo-glutaryl-[acp] methyl ester reductase activity|3-oxo-pimeloyl-[acp] methyl ester reductase activity hsa00061,hsa04152,hsa04910 Fatty acid biosynthesis|AMPK signaling pathway|Insulin signaling pathway FASTK 2136.67136760515 1997.05441122187 2276.28832398842 1.13982288674634 0.188809666263758 0.187389492277376 1 34.8665 37.1011 42.04 41.118 GeneID:10922,Genbank:NM_033015.3,HGNC:HGNC:24676,MIM:606965 Fas activated serine/threonine kinase GO:0003723,GO:0004674,GO:0005524,GO:0005759,GO:0006468,GO:0033867,GO:0043484,GO:0097190 RNA binding|protein serine/threonine kinase activity|ATP binding|mitochondrial matrix|protein phosphorylation|Fas-activated serine/threonine kinase activity|regulation of RNA splicing|apoptotic signaling pathway FASTKD1 204.676443582224 215.473461378658 193.87942578579 0.899783316911964 -0.152350477060763 0.516288247567358 1 0.874637 0.885844 0.946591 0.698688 GeneID:79675,Genbank:XM_017004912.2,HGNC:HGNC:26150,MIM:617529 FAST kinase domains 1 GO:0000959,GO:0003723,GO:0004672,GO:0005739,GO:0044528,GO:0045333 mitochondrial RNA metabolic process|RNA binding|protein kinase activity|mitochondrion|regulation of mitochondrial mRNA stability|cellular respiration FASTKD2 275.014904307281 311.583257090384 238.446551524179 0.76527395518884 -0.385951794088085 0.0624661246878381 0.89203234548829 2.25594 1.89744 1.73731 1.47634 GeneID:22868,Genbank:NM_001136194.1,HGNC:HGNC:29160,MIM:612322 FAST kinase domains 2 GO:0003723,GO:0004672,GO:0005634,GO:0005739,GO:0019843,GO:0035770,GO:0042645,GO:0045171,GO:0045333,GO:1902775 RNA binding|protein kinase activity|nucleus|mitochondrion|rRNA binding|ribonucleoprotein granule|mitochondrial nucleoid|intercellular bridge|cellular respiration|mitochondrial large ribosomal subunit assembly FASTKD3 197.209264054203 227.696837463123 166.721690645283 0.732209074587102 -0.449672441183877 0.0461606484157697 0.79332376136203 3.13955 3.90797 2.68653 2.3576 GeneID:79072,Genbank:XM_006714498.1,HGNC:HGNC:28758,MIM:617530 FAST kinase domains 3 GO:0003723,GO:0004672,GO:0005634,GO:0005739,GO:0033617,GO:0044528,GO:0045333,GO:0070131 RNA binding|protein kinase activity|nucleus|mitochondrion|mitochondrial respiratory chain complex IV assembly|regulation of mitochondrial mRNA stability|cellular respiration|positive regulation of mitochondrial translation FASTKD5 463.944413004631 428.688670846268 499.200155162994 1.1644818002247 0.219688091733614 0.207232149639577 1 7.56196 6.83141 9.16879 7.65101 GeneID:60493,Genbank:NM_021826.4,HGNC:HGNC:25790,MIM:614272 FAST kinase domains 5 GO:0000963,GO:0003723,GO:0004672,GO:0005739,GO:0006397,GO:0019843,GO:0035770,GO:0042645,GO:0045333 mitochondrial RNA processing|RNA binding|protein kinase activity|mitochondrion|mRNA processing|rRNA binding|ribonucleoprotein granule|mitochondrial nucleoid|cellular respiration FAT1 4144.67463410437 3980.56200062659 4308.78726758215 1.08245701659813 0.114309737957156 0.738600418152535 1 8.69852 8.1811 11.7268 6.74755 GeneID:2195,Genbank:NM_005245.3,HGNC:HGNC:3595,MIM:600976 FAT atypical cadherin 1 FAT2 3.67692633838173 3.47852608838648 3.87532658837698 1.11407144575263 0.155841756132028 1 1 0.00224014 0.0121536 0.0042286 0.0118384 GeneID:2196,Genbank:XM_017009225.1,HGNC:HGNC:3596,MIM:604269 FAT atypical cadherin 2 GO:0005509,GO:0005634,GO:0005886,GO:0005913,GO:0007156,GO:0010631,GO:0016021,GO:0070062 calcium ion binding|nucleus|plasma membrane|cell-cell adherens junction|homophilic cell adhesion via plasma membrane adhesion molecules|epithelial cell migration|integral component of membrane|extracellular exosome FAT3 91.5204566467191 102.086705084585 80.9542082088536 0.792994622970527 -0.334617011354143 0.366591087869217 1 0.139607 0.13686 0.14943 0.0728254 GeneID:120114,Genbank:XM_017017186.1,HGNC:HGNC:23112,MIM:612483 FAT atypical cadherin 3 GO:0005509,GO:0005886,GO:0007156,GO:0007275,GO:0016021 calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|multicellular organism development|integral component of membrane FAT4 150.389447909727 149.516752869116 151.262142950338 1.01167354191239 0.0167438202235938 0.976271376568888 1 0.34871 0.272934 0.46093 0.174995 GeneID:79633,Genbank:XM_011532236.2,HGNC:HGNC:23109,MIM:612411 FAT atypical cadherin 4 GO:0001658,GO:0003007,GO:0005509,GO:0005622,GO:0005886,GO:0007009,GO:0007156,GO:0007157,GO:0007219,GO:0008543,GO:0016021,GO:0021987,GO:0022008,GO:0035329,GO:0043931,GO:0045177,GO:0048565,GO:0060122,GO:0070062,GO:0072137,GO:0072307 branching involved in ureteric bud morphogenesis|heart morphogenesis|calcium ion binding|intracellular|plasma membrane|plasma membrane organization|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|Notch signaling pathway|fibroblast growth factor receptor signaling pathway|integral component of membrane|cerebral cortex development|neurogenesis|hippo signaling|ossification involved in bone maturation|apical part of cell|digestive tract development|inner ear receptor cell stereocilium organization|extracellular exosome|condensed mesenchymal cell proliferation|regulation of metanephric nephron tubule epithelial cell differentiation hsa04392 Hippo signaling pathway - multiple species FAU 4074.60179351947 4193.73731982635 3955.46626721258 0.943184077961363 -0.0843887307258221 0.72666324248343 1 361.77 388.506 308.56 403.109 GeneID:2197,Genbank:NM_001997.4,HGNC:HGNC:3597,MIM:134690 FAU, ubiquitin like and ribosomal protein S30 fusion hsa03010 Ribosome FAXC 803.779183331122 773.99080212234 833.567564539904 1.07697347598214 0.106982719204093 0.497587992090709 1 2.30329 2.37301 2.63864 2.51915 GeneID:84553,Genbank:NM_001346530.1,HGNC:HGNC:20742 failed axon connections homolog GO:0016021 integral component of membrane FAXDC2 166.418026851296 163.238752123922 169.59730157867 1.03895245076317 0.0551296286233323 0.828812779131151 1 0.964735 1.04582 0.917573 1.11701 GeneID:10826,Genbank:XM_017008965.1,HGNC:HGNC:1334 fatty acid hydroxylase domain containing 2 GO:0005506,GO:0005789,GO:0006629,GO:0008610,GO:0016021,GO:0016491 iron ion binding|endoplasmic reticulum membrane|lipid metabolic process|lipid biosynthetic process|integral component of membrane|oxidoreductase activity FBF1 275.763423101819 236.046651605759 315.480194597879 1.33651628799543 0.418477419673803 0.0411995075624013 0.759435523043776 1.4632 1.56509 2.00243 2.11171 GeneID:85302,Genbank:NM_001319193.1,HGNC:HGNC:24674,MIM:616807 Fas binding factor 1 GO:0000922,GO:0005813,GO:0005814,GO:0005829,GO:0030054,GO:0043297,GO:0060271,GO:0090162,GO:0097539,GO:0097711 spindle pole|centrosome|centriole|cytosol|cell junction|apical junction assembly|cilium assembly|establishment of epithelial cell polarity|ciliary transition fiber|ciliary basal body-plasma membrane docking FBH1 1748.93555685048 1772.12449738112 1725.74661631984 0.973829219600644 -0.0382593057811302 0.773100129505094 1 11.3722 12.1963 11.4812 11.3 GeneID:84893,Genbank:NM_001258452.1,HGNC:HGNC:13620,MIM:607222 F-box DNA helicase 1 GO:0000724,GO:0000737,GO:0000785,GO:0001934,GO:0003678,GO:0003690,GO:0003697,GO:0004003,GO:0005524,GO:0005634,GO:0006974,GO:0008219,GO:0015616,GO:0016567,GO:0019005,GO:0031297,GO:0035562,GO:0043138,GO:0048478,GO:0072429,GO:1902231,GO:2000042 double-strand break repair via homologous recombination|DNA catabolic process, endonucleolytic|chromatin|positive regulation of protein phosphorylation|DNA helicase activity|double-stranded DNA binding|single-stranded DNA binding|ATP-dependent DNA helicase activity|ATP binding|nucleus|cellular response to DNA damage stimulus|cell death|DNA translocase activity|protein ubiquitination|SCF ubiquitin ligase complex|replication fork processing|negative regulation of chromatin binding|3'-5' DNA helicase activity|replication fork protection|response to intra-S DNA damage checkpoint signaling|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|negative regulation of double-strand break repair via homologous recombination FBL 4335.3853269096 4523.03551462294 4147.73513919626 0.917024667568199 -0.124967552670458 0.348575350752753 1 127.583 125.104 112.945 118.886 GeneID:2091,Genbank:NM_001436.3,HGNC:HGNC:3599,MIM:134795 fibrillarin GO:0000494,GO:0001094,GO:0001649,GO:0001650,GO:0001651,GO:0001652,GO:0003723,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0006364,GO:0008033,GO:0008649,GO:0015030,GO:0016020,GO:0031167,GO:0031428,GO:0032040,GO:0048254,GO:0051117,GO:0070062,GO:1990258,GO:1990259 box C/D snoRNA 3'-end processing|TFIID-class transcription factor binding|osteoblast differentiation|fibrillar center|dense fibrillar component|granular component|RNA binding|nucleus|nucleoplasm|chromosome|nucleolus|rRNA processing|tRNA processing|rRNA methyltransferase activity|Cajal body|membrane|rRNA methylation|box C/D snoRNP complex|small-subunit processome|snoRNA localization|ATPase binding|extracellular exosome|histone glutamine methylation|histone-glutamine methyltransferase activity hsa03008 Ribosome biogenesis in eukaryotes FBLIM1 2849.47818171039 2991.53404160118 2707.4223218196 0.905028083976104 -0.143965533647971 0.287106856196839 1 21.9808 22.0162 19.0266 21.5614 GeneID:54751,Genbank:XM_017001521.2,HGNC:HGNC:24686,MIM:607747 filamin binding LIM protein 1 GO:0001650,GO:0001725,GO:0005829,GO:0005925,GO:0005938,GO:0008360,GO:0030054,GO:0031005,GO:0033623,GO:0034329,GO:0046872,GO:0098609 fibrillar center|stress fiber|cytosol|focal adhesion|cell cortex|regulation of cell shape|cell junction|filamin binding|regulation of integrin activation|cell junction assembly|metal ion binding|cell-cell adhesion FBLL1 14.0523590446238 13.078040373686 15.0266777155615 1.14900071311879 0.200379693382301 0.867575338985032 1 0.345106 0.679358 0.848335 0.495018 GeneID:345630,Genbank:NM_001355274.1,HGNC:HGNC:35458 fibrillarin like 1 GO:0000494,GO:0001650,GO:0003723,GO:0005634,GO:0008033,GO:0008649,GO:0015030,GO:0031167,GO:0031428,GO:0032040,GO:1990258,GO:1990259 box C/D snoRNA 3'-end processing|fibrillar center|RNA binding|nucleus|tRNA processing|rRNA methyltransferase activity|Cajal body|rRNA methylation|box C/D snoRNP complex|small-subunit processome|histone glutamine methylation|histone-glutamine methyltransferase activity FBLN1 3340.3016470413 3122.56641936828 3558.03687471433 1.13945914893754 0.188349203074762 0.177007668117981 1 23.99 27.0705 29.6872 29.7991 GeneID:2192,Genbank:NM_006486.2,HGNC:HGNC:3600,MIM:135820 fibulin 1 GO:0005509,GO:0005578,GO:0016504,GO:0030198 calcium ion binding|proteinaceous extracellular matrix|peptidase activator activity|extracellular matrix organization FBLN2 4.42103728054967 2.05633815719933 6.7857364039 3.29991270168422 1.72242785886104 0.268245773715959 1 0.0220236 0.0188171 0.0711774 0.0569269 GeneID:2199,Genbank:NM_001004019.1,HGNC:HGNC:3601,MIM:135821 fibulin 2 GO:0005201,GO:0005509,GO:0005576,GO:0005578,GO:0010811,GO:0030198,GO:0031012,GO:0050840,GO:0070062,GO:1903561 extracellular matrix structural constituent|calcium ion binding|extracellular region|proteinaceous extracellular matrix|positive regulation of cell-substrate adhesion|extracellular matrix organization|extracellular matrix|extracellular matrix binding|extracellular exosome|extracellular vesicle FBLN5 56.2122082312392 46.0274771635603 66.3969392989181 1.4425500459861 0.52862137075535 0.17431109622503 1 0.395512 0.517488 0.679896 0.659712 GeneID:10516,Genbank:NM_006329.3,HGNC:HGNC:3602,MIM:604580 fibulin 5 GO:0001558,GO:0005178,GO:0005509,GO:0005576,GO:0005578,GO:0005615,GO:0007160,GO:0008022,GO:0030198,GO:0031012,GO:0034394,GO:0042803,GO:0046903,GO:0048251,GO:0070062,GO:0071953,GO:2000121 regulation of cell growth|integrin binding|calcium ion binding|extracellular region|proteinaceous extracellular matrix|extracellular space|cell-matrix adhesion|protein C-terminus binding|extracellular matrix organization|extracellular matrix|protein localization to cell surface|protein homodimerization activity|secretion|elastic fiber assembly|extracellular exosome|elastic fiber|regulation of removal of superoxide radicals FBLN7 8.3325710413378 8.90752912949446 7.75761295318113 0.870905145568848 -0.199412498301379 0.934191341017857 1 0.0694194 0.0321339 0.0594682 0.0184555 GeneID:129804,Genbank:XM_017003317.1,HGNC:HGNC:26740,MIM:611551 fibulin 7 GO:0005509,GO:0005578,GO:0005925,GO:0007155,GO:0008201,GO:0070062 calcium ion binding|proteinaceous extracellular matrix|focal adhesion|cell adhesion|heparin binding|extracellular exosome FBN1 940.857706549057 802.298256575426 1079.41715652269 1.34540633445987 0.428041955813735 0.0897329360838058 0.979717040875575 2.35957 2.02968 3.61197 2.54075 GeneID:2200,Genbank:NM_000138.4,HGNC:HGNC:3603,MIM:134797 fibrillin 1 GO:0001501,GO:0001527,GO:0001656,GO:0005178,GO:0005179,GO:0005201,GO:0005509,GO:0005576,GO:0005578,GO:0005604,GO:0005615,GO:0005622,GO:0005788,GO:0006006,GO:0007507,GO:0008201,GO:0010737,GO:0022617,GO:0030023,GO:0030198,GO:0031012,GO:0032403,GO:0033627,GO:0034199,GO:0035582,GO:0035583,GO:0042593,GO:0042802,GO:0043010,GO:0043687,GO:0044267,GO:0045671,GO:0048048,GO:0048050,GO:0070062,GO:0071560,GO:0090287,GO:1990314,GO:2001205 skeletal system development|microfibril|metanephros development|integrin binding|hormone activity|extracellular matrix structural constituent|calcium ion binding|extracellular region|proteinaceous extracellular matrix|basement membrane|extracellular space|intracellular|endoplasmic reticulum lumen|glucose metabolic process|heart development|heparin binding|protein kinase A signaling|extracellular matrix disassembly|extracellular matrix constituent conferring elasticity|extracellular matrix organization|extracellular matrix|protein complex binding|cell adhesion mediated by integrin|activation of protein kinase A activity|sequestering of BMP in extracellular matrix|sequestering of TGFbeta in extracellular matrix|glucose homeostasis|identical protein binding|camera-type eye development|post-translational protein modification|cellular protein metabolic process|negative regulation of osteoclast differentiation|embryonic eye morphogenesis|post-embryonic eye morphogenesis|extracellular exosome|cellular response to transforming growth factor beta stimulus|regulation of cellular response to growth factor stimulus|cellular response to insulin-like growth factor stimulus|negative regulation of osteoclast development FBN2 406.678973605878 402.82176474786 410.536182463896 1.01915094563191 0.0273677437383127 0.907989286162491 1 1.27183 1.31804 1.52655 1.10418 GeneID:2201,Genbank:NM_001999.3,HGNC:HGNC:3604,MIM:612570 fibrillin 2 GO:0001527,GO:0005201,GO:0005509,GO:0005576,GO:0005578,GO:0022617,GO:0030023,GO:0030198,GO:0030326,GO:0030501,GO:0031012,GO:0035583,GO:0043010,GO:0045669,GO:0048048,GO:0060346,GO:0090287 microfibril|extracellular matrix structural constituent|calcium ion binding|extracellular region|proteinaceous extracellular matrix|extracellular matrix disassembly|extracellular matrix constituent conferring elasticity|extracellular matrix organization|embryonic limb morphogenesis|positive regulation of bone mineralization|extracellular matrix|sequestering of TGFbeta in extracellular matrix|camera-type eye development|positive regulation of osteoblast differentiation|embryonic eye morphogenesis|bone trabecula formation|regulation of cellular response to growth factor stimulus FBP1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0267935 0 GeneID:2203,Genbank:XM_006717005.4,HGNC:HGNC:3606,MIM:611570 fructose-bisphosphatase 1 hsa00010,hsa00030,hsa00051,hsa04152,hsa04910,hsa04922 Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|AMPK signaling pathway|Insulin signaling pathway|Glucagon signaling pathway FBP2 0.974704718517834 0.980142803914724 0.969266633120943 0.98890348350226 -0.0160983733645535 1 1 0 0 0 0 GeneID:8789,Genbank:NM_003837.3,HGNC:HGNC:3607,MIM:603027 fructose-bisphosphatase 2 GO:0005654,GO:0005829,GO:0005886,GO:0005986,GO:0006000,GO:0006002,GO:0006094,GO:0030018,GO:0030054,GO:0030388,GO:0042132,GO:0042802,GO:0046872,GO:0070062 nucleoplasm|cytosol|plasma membrane|sucrose biosynthetic process|fructose metabolic process|fructose 6-phosphate metabolic process|gluconeogenesis|Z disc|cell junction|fructose 1,6-bisphosphate metabolic process|fructose 1,6-bisphosphate 1-phosphatase activity|identical protein binding|metal ion binding|extracellular exosome hsa00010,hsa00030,hsa00051,hsa04152,hsa04910 Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|AMPK signaling pathway|Insulin signaling pathway FBRS 1631.66000921416 1569.13416077056 1694.18585765775 1.07969471318232 0.110623443833834 0.503212875769456 1 11.838 13.1603 13.4115 14.0687 GeneID:64319,Genbank:XM_011545916.3,HGNC:HGNC:20442,MIM:608601 fibrosin FBRSL1 560.48230876364 564.609919976126 556.354697551154 0.985378892341599 -0.0212495266675993 0.89144479128658 1 1.94529 2.02995 1.92955 1.94271 GeneID:57666,Genbank:XM_005266181.4,HGNC:HGNC:29308 fibrosin like 1 GO:0003723 RNA binding FBXL12 436.02363156459 462.513406236434 409.533856892746 0.885452943354025 -0.175512456677753 0.325724775862836 1 7.42872 7.30202 7.09238 6.06539 GeneID:54850,Genbank:XM_017026912.2,HGNC:HGNC:13611,MIM:609079 F-box and leucine rich repeat protein 12 GO:0000151,GO:0000209,GO:0004842,GO:0005829,GO:0006511,GO:0043687 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL13 15.3386053304705 19.0451410914363 11.6320695695047 0.610763108220558 -0.711315172887902 0.344574760173344 1 0.0679452 0.0830439 0.047647 0.00553456 GeneID:222235,Genbank:XM_005250207.4,HGNC:HGNC:21658,MIM:609080 F-box and leucine rich repeat protein 13 GO:0000209,GO:0004842,GO:0005829,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|post-translational protein modification FBXL14 318.159309182897 318.867701535698 317.450916830097 0.995556825922543 -0.00642442822652468 0.959527948989647 1 0.950955 1.1447 1.124 0.879761 GeneID:144699,Genbank:XM_017018875.2,HGNC:HGNC:28624,MIM:609081 F-box and leucine rich repeat protein 14 GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0042787,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL15 289.331363146219 270.927965038993 307.734761253446 1.13585454793917 0.183778102094346 0.379597271596426 1 3.60942 4.37396 4.48795 4.62665 GeneID:79176,Genbank:XM_005270149.2,HGNC:HGNC:28155,MIM:610287 F-box and leucine rich repeat protein 15 GO:0000086,GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0009953,GO:0016567,GO:0019005,GO:0030282,GO:0030513,GO:0031146,GO:0043687 G2/M transition of mitotic cell cycle|protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|dorsal/ventral pattern formation|protein ubiquitination|SCF ubiquitin ligase complex|bone mineralization|positive regulation of BMP signaling pathway|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL16 6.85695236570769 8.86931150991746 4.84459322149792 0.546219761937644 -0.872446583908139 0.654621099386355 1 0.0127094 0.147804 0.034584 0.0755064 GeneID:146330,Genbank:XM_024450160.1,HGNC:HGNC:14150,MIM:609082 F-box and leucine rich repeat protein 16 GO:0000209,GO:0004842,GO:0005829,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|post-translational protein modification FBXL17 486.909717034576 459.562152168727 514.257281900425 1.11901574025099 0.16223032963185 0.515875840325043 1 1.00453 0.826163 1.19799 0.82715 GeneID:64839,Genbank:NM_001163315.2,HGNC:HGNC:13615,MIM:609083 F-box and leucine rich repeat protein 17 FBXL18 1505.86173779621 1505.96297619275 1505.76049939968 0.999865549952906 -0.00019398345702515 0.981504265633925 1 7.14518 7.70823 7.86862 7.3657 GeneID:80028,Genbank:XM_011515531.3,HGNC:HGNC:21874,MIM:609084 F-box and leucine rich repeat protein 18 GO:0000209,GO:0004842,GO:0005829,GO:0031146,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL19 737.511757243911 740.791425303933 734.232089183889 0.991145502099524 -0.0128312314728845 0.946608227445418 1 7.60623 7.00821 7.62733 7.09414 GeneID:54620,Genbank:NM_001282351.1,HGNC:HGNC:25300,MIM:609085 F-box and leucine rich repeat protein 19 GO:0000209,GO:0003677,GO:0004842,GO:0005829,GO:0008270,GO:0019005,GO:0043161,GO:0043687 protein polyubiquitination|DNA binding|ubiquitin-protein transferase activity|cytosol|zinc ion binding|SCF ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification FBXL2 237.030899125596 238.535226235123 235.526572016069 0.987386960548593 -0.0183125019413236 0.954985889530565 1 1.49826 1.37412 1.52824 1.52553 GeneID:25827,Genbank:NM_001349319.1,HGNC:HGNC:13598,MIM:605652 F-box and leucine rich repeat protein 2 GO:0004842,GO:0005516,GO:0005737,GO:0006464,GO:0006508,GO:0006513,GO:0010506,GO:0014066,GO:0016020,GO:0016032,GO:0016567,GO:0019005,GO:0019903,GO:0031146,GO:0036312,GO:0044830 ubiquitin-protein transferase activity|calmodulin binding|cytoplasm|cellular protein modification process|proteolysis|protein monoubiquitination|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|membrane|viral process|protein ubiquitination|SCF ubiquitin ligase complex|protein phosphatase binding|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|phosphatidylinositol 3-kinase regulatory subunit binding|modulation by host of viral RNA genome replication FBXL20 326.127642525475 334.80871808112 317.44656696983 0.948143073421752 -0.0768233187367434 0.696994933564281 1 1.26496 1.3438 1.39296 1.16811 GeneID:84961,Genbank:XM_005257746.3,HGNC:HGNC:24679,MIM:609086 F-box and leucine rich repeat protein 20 GO:0000209,GO:0001662,GO:0004842,GO:0005829,GO:0043687 protein polyubiquitination|behavioral fear response|ubiquitin-protein transferase activity|cytosol|post-translational protein modification FBXL22 4.90741054121693 2.05633815719933 7.75848292523453 3.77296063785605 1.91569704903058 0.278654340339052 1 0.0101302 0.00925285 0.0620346 0.0133768 GeneID:283807,Genbank:XM_005254320.4,HGNC:HGNC:27537,MIM:609088 F-box and leucine rich repeat protein 22 GO:0000209,GO:0004842,GO:0005730,GO:0005829,GO:0030018,GO:0043161,GO:0043687,GO:0061630 protein polyubiquitination|ubiquitin-protein transferase activity|nucleolus|cytosol|Z disc|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|ubiquitin protein ligase activity FBXL3 485.756568345487 512.54668150906 458.966455181915 0.895462738790167 -0.15929469358742 0.385192061471033 1 6.56343 5.84485 6.10502 5.21175 GeneID:26224,Genbank:XM_017020538.2,HGNC:HGNC:13599,MIM:605653 F-box and leucine rich repeat protein 3 GO:0000151,GO:0000209,GO:0004842,GO:0005634,GO:0005829,GO:0016567,GO:0016604,GO:0019005,GO:0031146,GO:0031648,GO:0042752,GO:0043153,GO:0043687,GO:0048511 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|cytosol|protein ubiquitination|nuclear body|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein destabilization|regulation of circadian rhythm|entrainment of circadian clock by photoperiod|post-translational protein modification|rhythmic process hsa04710 Circadian rhythm FBXL4 243.763209887998 251.98766815118 235.538751624816 0.93472332734753 -0.0973886960170428 0.67805202389515 1 1.19376 1.0513 1.14557 0.963096 GeneID:26235,Genbank:XM_017010728.1,HGNC:HGNC:13601,MIM:605654 F-box and leucine rich repeat protein 4 GO:0000151,GO:0000209,GO:0004842,GO:0005758,GO:0005829,GO:0006511,GO:0016607,GO:0043687 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|mitochondrial intermembrane space|cytosol|ubiquitin-dependent protein catabolic process|nuclear speck|post-translational protein modification FBXL5 2005.95690530011 1982.32080919612 2029.5930014041 1.02384689298961 0.0339999895180021 0.805120011985344 1 17.538 17.9278 18.2757 18.0648 GeneID:26234,Genbank:NM_001193535.1,HGNC:HGNC:13602,MIM:605655 F-box and leucine rich repeat protein 5 GO:0000151,GO:0000209,GO:0004842,GO:0005506,GO:0005829,GO:0006879,GO:0016567,GO:0019005,GO:0031146,GO:0043687,GO:0048471,GO:0055072,GO:1903364 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|iron ion binding|cytosol|cellular iron ion homeostasis|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|perinuclear region of cytoplasm|iron ion homeostasis|positive regulation of cellular protein catabolic process FBXL6 239.268929709461 234.307897061993 244.229962356929 1.0423462692438 0.0598346230426704 0.824146396030492 1 7.66468 8.18575 8.18274 8.92235 GeneID:26233,Genbank:NM_024555.5,HGNC:HGNC:13603,MIM:609076 F-box and leucine rich repeat protein 6 GO:0004842,GO:0006508 ubiquitin-protein transferase activity|proteolysis FBXL7 661.306686221691 603.900859026123 718.712513417259 1.19011672640487 0.251103079707027 0.125850244297874 1 2.62083 2.62865 3.28049 3.05897 GeneID:23194,Genbank:NM_012304.4,HGNC:HGNC:13604,MIM:605656 F-box and leucine rich repeat protein 7 GO:0000086,GO:0000151,GO:0000209,GO:0000278,GO:0004842,GO:0005813,GO:0005829,GO:0006511,GO:0008283,GO:0010265,GO:0010972,GO:0016567,GO:0019005,GO:0031146,GO:0043687,GO:0051301 G2/M transition of mitotic cell cycle|ubiquitin ligase complex|protein polyubiquitination|mitotic cell cycle|ubiquitin-protein transferase activity|centrosome|cytosol|ubiquitin-dependent protein catabolic process|cell proliferation|SCF complex assembly|negative regulation of G2/M transition of mitotic cell cycle|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|cell division FBXL8 31.8066038079877 27.2704937202336 36.3427138957417 1.33267531818747 0.414325337143506 0.416825672310193 1 1.57472 1.2085 2.14637 2.54394 GeneID:55336,Genbank:NM_018378.2,HGNC:HGNC:17875,MIM:609077 F-box and leucine rich repeat protein 8 GO:0000209,GO:0004842,GO:0005829,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|post-translational protein modification FBXO10 437.2883840022 428.198599444311 446.37816856009 1.04245592848592 0.0599863926878782 0.724579906883975 1 2.56637 2.15749 2.70784 2.14683 GeneID:26267,Genbank:XM_017014618.1,HGNC:HGNC:13589,MIM:609092 F-box protein 10 GO:0000151,GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0006915,GO:0016567,GO:0042787,GO:0042981,GO:0043687 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|apoptotic process|protein ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of apoptotic process|post-translational protein modification FBXO11 701.485025474612 696.339006549868 706.631044399357 1.01478021158183 0.021167291945402 0.871959902011164 1 5.62596 5.10903 5.97297 5.06953 GeneID:80204,Genbank:NM_001190274.1,HGNC:HGNC:13590,MIM:607871 F-box protein 11 GO:0000151,GO:0000209,GO:0004842,GO:0005634,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0006464,GO:0006511,GO:0007605,GO:0008270,GO:0016274,GO:0016567,GO:0043687 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|chromosome|nucleolus|cytoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|sensory perception of sound|zinc ion binding|protein-arginine N-methyltransferase activity|protein ubiquitination|post-translational protein modification FBXO15 4.72116891924188 4.11267631439867 5.32966152408509 1.29591076871907 0.373966383378072 0.859977289674363 1 0.0172903 0.00833761 0.0083572 0.0155598 GeneID:201456,Genbank:XM_011525856.1,HGNC:HGNC:13617,MIM:609093 F-box protein 15 GO:0000151,GO:0000209,GO:0004842,GO:0005829,GO:0043161,GO:0043687 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification FBXO16 50.6053640016544 48.3817816239772 52.8289463793317 1.09191816849404 0.126864740569551 0.794988592788811 1 0.724888 0.800914 0.735893 0.567769 GeneID:157574,Genbank:NM_001258211.1,HGNC:HGNC:13618,MIM:608519 F-box protein 16 FBXO17 793.972355939133 718.057052716009 869.887659162257 1.21144643851343 0.276730620555447 0.083601616645588 0.963076417285947 9.53655 10.3354 12.341 12.7541 GeneID:115290,Genbank:NM_024907.6,HGNC:HGNC:18754,MIM:609094 F-box protein 17 GO:0000209,GO:0004842,GO:0005829,GO:0019005,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|SCF ubiquitin ligase complex|post-translational protein modification FBXO2 35.0311617954638 25.9541669935243 44.1081565974034 1.69946338899679 0.765079282690588 0.118850326231544 1 0.749761 0.922451 1.79121 1.13927 GeneID:26232,Genbank:NM_012168.5,HGNC:HGNC:13581,MIM:607112 F-box protein 2 GO:0000209,GO:0001540,GO:0004842,GO:0005737,GO:0005783,GO:0005829,GO:0006464,GO:0006508,GO:0006516,GO:0008285,GO:0016567,GO:0019005,GO:0030246,GO:0030433,GO:0031090,GO:0031146,GO:0031396,GO:0043197,GO:0043687,GO:0070062 protein polyubiquitination|amyloid-beta binding|ubiquitin-protein transferase activity|cytoplasm|endoplasmic reticulum|cytosol|cellular protein modification process|proteolysis|glycoprotein catabolic process|negative regulation of cell proliferation|protein ubiquitination|SCF ubiquitin ligase complex|carbohydrate binding|ubiquitin-dependent ERAD pathway|organelle membrane|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of protein ubiquitination|dendritic spine|post-translational protein modification|extracellular exosome hsa04120,hsa04141 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum FBXO21 830.632938904721 827.195845525882 834.070032283559 1.00831022882291 0.0119395840021011 0.93182821932448 1 7.37067 7.26889 7.9773 7.07326 GeneID:23014,Genbank:XM_017019037.2,HGNC:HGNC:13592,MIM:609095 F-box protein 21 GO:0003677 DNA binding FBXO22 727.509108657446 735.871093974144 719.147123340749 0.977273233355213 -0.0331661168331022 0.859383740619919 1 6.82744 6.75435 6.18128 6.94889 GeneID:26263,Genbank:NM_147188.2,HGNC:HGNC:13593,MIM:609096 F-box protein 22 GO:0000209,GO:0004842,GO:0005634,GO:0005829,GO:0006464,GO:0006511,GO:0006913,GO:0009267,GO:0030018,GO:0032436,GO:0043687,GO:0048742,GO:2000060 protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|nucleocytoplasmic transport|cellular response to starvation|Z disc|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|post-translational protein modification|regulation of skeletal muscle fiber development|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process FBXO24 7.55520236866531 8.81147658012458 6.29892815720603 0.714855007549368 -0.484277441949909 0.706842616370909 1 0.0472412 0.0210736 0.022113 0.0414415 GeneID:26261,Genbank:XM_017011961.1,HGNC:HGNC:13595,MIM:609097 F-box protein 24 GO:0000151,GO:0004842,GO:0016567 ubiquitin ligase complex|ubiquitin-protein transferase activity|protein ubiquitination FBXO25 697.799161090787 669.665462436924 725.932859744649 1.08402314359018 0.116395558155217 0.477595726233447 1 8.00915 8.62918 8.93696 9.47682 GeneID:26260,Genbank:NM_183421.1,HGNC:HGNC:13596,MIM:609098 F-box protein 25 GO:0003779,GO:0005634,GO:0016567,GO:0019005 actin binding|nucleus|protein ubiquitination|SCF ubiquitin ligase complex hsa04068 FoxO signaling pathway FBXO27 57.5032633843596 57.3373370281566 57.6691897405626 1.00578772453703 0.00832585079656616 1 1 0.738503 0.674166 0.721063 0.759232 GeneID:126433,Genbank:XM_017026290.1,HGNC:HGNC:18753,MIM:609099 F-box protein 27 GO:0000209,GO:0004842,GO:0005829,GO:0019005,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|SCF ubiquitin ligase complex|post-translational protein modification FBXO28 760.654013841964 819.969236010361 701.338791673568 0.85532329857398 -0.225458256071985 0.262386117759143 1 7.46466 6.84339 7.18956 5.19494 GeneID:23219,Genbank:NM_015176.3,HGNC:HGNC:29046,MIM:609100 F-box protein 28 GO:0000776,GO:0000777 kinetochore|condensed chromosome kinetochore FBXO3 425.913125129164 444.255285849318 407.570964409009 0.917425132330894 -0.124337665129899 0.51488635492016 1 3.19332 3.08266 2.84334 2.78575 GeneID:26273,Genbank:NM_012175.3,HGNC:HGNC:13582,MIM:609089 F-box protein 3 GO:0004842,GO:0005654,GO:0005829,GO:0006508 ubiquitin-protein transferase activity|nucleoplasm|cytosol|proteolysis FBXO30 324.308754657523 344.234727577041 304.382781738005 0.884230315402689 -0.177505897655572 0.378484425164826 1 1.7015 1.63094 1.76725 1.30494 GeneID:84085,Genbank:NM_001348092.1,HGNC:HGNC:15600,MIM:609101 F-box protein 30 GO:0000209,GO:0004842,GO:0005829,GO:0008270,GO:0043687,GO:0061630 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|zinc ion binding|post-translational protein modification|ubiquitin protein ligase activity FBXO31 695.822484330601 692.34301709591 699.301951565292 1.01005128136999 0.014428541987013 0.940849466892605 1 5.03723 5.0272 5.10395 5.22146 GeneID:79791,Genbank:NM_001282683.1,HGNC:HGNC:16510,MIM:609102 F-box protein 31 FBXO32 9395.75408842949 9324.43427520678 9467.07390165221 1.0152974027416 0.0219023861430524 0.864958090004111 1 40.1713 40.8981 40.7901 39.475 GeneID:114907,Genbank:NM_001242463.1,HGNC:HGNC:16731,MIM:606604 F-box protein 32 GO:0000209,GO:0004842,GO:0005654,GO:0005737,GO:0005829,GO:0014894,GO:0016567,GO:0019005,GO:0030018,GO:0043687,GO:0071549 protein polyubiquitination|ubiquitin-protein transferase activity|nucleoplasm|cytoplasm|cytosol|response to denervation involved in regulation of muscle adaptation|protein ubiquitination|SCF ubiquitin ligase complex|Z disc|post-translational protein modification|cellular response to dexamethasone stimulus hsa04068 FoxO signaling pathway FBXO33 470.93079450627 466.404551486769 475.457037525772 1.01940908597514 0.0277331171285939 0.873038643221348 1 4.39543 4.47115 4.98701 4.07368 GeneID:254170,Genbank:NM_203301.3,HGNC:HGNC:19833,MIM:609103 F-box protein 33 GO:0016567 protein ubiquitination FBXO34 623.469769003715 606.255163486539 640.68437452089 1.05678996750535 0.0796886757293768 0.635544783009449 1 4.12608 4.43046 4.65316 4.42887 GeneID:55030,Genbank:NM_017943.3,HGNC:HGNC:20201,MIM:609104 F-box protein 34 FBXO36 53.6646423191882 56.9335095204612 50.3957751179152 0.88516895484554 -0.175975241891005 0.696397166921666 1 0.744462 0.364784 0.406254 0.528426 GeneID:130888,Genbank:NM_174899.4,HGNC:HGNC:27020,MIM:609105 F-box protein 36 FBXO38 667.877933265273 674.238784187957 661.51708234259 0.981131756072608 -0.027481206079119 0.88448233210602 1 3.5335 3.50976 3.39538 3.43202 GeneID:81545,Genbank:NM_030793.4,HGNC:HGNC:28844,MIM:608533 F-box protein 38 GO:0005634,GO:0005737,GO:0010976 nucleus|cytoplasm|positive regulation of neuron projection development FBXO39 0.97720626820293 1.47021420587209 0.484198330533773 0.329338628752101 -1.60235635659317 0.793508671995383 1 0 0.0630825 0 0.0202646 GeneID:162517,Genbank:NM_153230.2,HGNC:HGNC:28565,MIM:609106 F-box protein 39 GO:0019005,GO:0031146 SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process FBXO4 239.275907495029 249.797059825034 228.754755165023 0.915762400587302 -0.126954762896005 0.56907876414802 1 1.02012 0.841321 0.852989 0.778521 GeneID:26272,Genbank:XM_011514026.3,HGNC:HGNC:13583,MIM:609090 F-box protein 4 GO:0000151,GO:0000209,GO:0000723,GO:0004842,GO:0005737,GO:0005829,GO:0006511,GO:0007568,GO:0010608,GO:0016567,GO:0019005,GO:0019725,GO:0031146,GO:0031398,GO:0031647,GO:0031648,GO:0032212,GO:0035726,GO:0042803,GO:0043687,GO:0048147,GO:0061630,GO:0071479,GO:1900181,GO:1902916,GO:2000001 ubiquitin ligase complex|protein polyubiquitination|telomere maintenance|ubiquitin-protein transferase activity|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|aging|posttranscriptional regulation of gene expression|protein ubiquitination|SCF ubiquitin ligase complex|cellular homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|regulation of protein stability|protein destabilization|positive regulation of telomere maintenance via telomerase|common myeloid progenitor cell proliferation|protein homodimerization activity|post-translational protein modification|negative regulation of fibroblast proliferation|ubiquitin protein ligase activity|cellular response to ionizing radiation|negative regulation of protein localization to nucleus|positive regulation of protein polyubiquitination|regulation of DNA damage checkpoint hsa04120 Ubiquitin mediated proteolysis FBXO41 127.310305216561 131.519398166495 123.101212266627 0.93599281917933 -0.0954306332134154 0.725528611556835 1 0.455578 0.48159 0.493815 0.418799 GeneID:150726,Genbank:NM_001080410.2,HGNC:HGNC:29409,MIM:609108 F-box protein 41 GO:0000209,GO:0004842,GO:0005829,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|post-translational protein modification FBXO42 887.006712175598 848.846248107123 925.167176244074 1.08991136888116 0.124210820438399 0.436959481148157 1 4.58159 5.24468 5.73398 5.32712 GeneID:54455,Genbank:NM_018994.2,HGNC:HGNC:29249,MIM:609109 F-box protein 42 FBXO43 1.75283499676863 1.56626675524197 1.93940323829528 1.23823303521223 0.308282855026159 1 1 0.0245667 0.0118604 0.0356197 0.0110401 GeneID:286151,Genbank:NM_001029860.3,HGNC:HGNC:28521,MIM:609110 F-box protein 43 GO:0005634,GO:0007088,GO:0016567,GO:0045835,GO:0046872,GO:0051321,GO:0051436 nucleus|regulation of mitotic nuclear division|protein ubiquitination|negative regulation of meiotic nuclear division|metal ion binding|meiotic cell cycle|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle hsa04114 Oocyte meiosis FBXO44 306.03089321465 312.073328492341 299.988457936959 0.961275541829332 -0.0569780677884983 0.79470115634812 1 3.30916 2.96551 3.27091 2.78107 GeneID:93611,Genbank:NM_001304791.1,HGNC:HGNC:24847,MIM:609111 F-box protein 44 FBXO45 852.931898284248 929.494273019422 776.369523549074 0.835260147463923 -0.259702490111372 0.098431040998794 1 7.49369 7.56435 6.36185 6.21175 GeneID:200933,Genbank:NM_001105573.1,HGNC:HGNC:29148,MIM:609112 F-box protein 45 GO:0001764,GO:0006974,GO:0014069,GO:0016567,GO:0021799,GO:0021800,GO:0021957,GO:0021960,GO:0030054,GO:0042734,GO:0042787,GO:0043161,GO:0045211,GO:0060386 neuron migration|cellular response to DNA damage stimulus|postsynaptic density|protein ubiquitination|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration|corticospinal tract morphogenesis|anterior commissure morphogenesis|cell junction|presynaptic membrane|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|postsynaptic membrane|synapse assembly involved in innervation FBXO46 434.831115187717 469.826259646217 399.835970729217 0.851029423153776 -0.232719082947652 0.18814239254635 1 4.95254 5.61541 4.94282 4.34848 GeneID:23403,Genbank:NM_001329633.1,HGNC:HGNC:25069,MIM:609117 F-box protein 46 FBXO48 25.9709916117812 23.3499225045747 28.5920607189877 1.22450345235133 0.292196841425875 0.600391563178442 1 0.372562 0.204276 0.32723 0.305358 GeneID:554251,Genbank:XM_017004437.2,HGNC:HGNC:33857 F-box protein 48 FBXO5 869.255784308101 983.428502197492 755.08306641871 0.767806774698375 -0.381184805110641 0.0165646843558715 0.534873364697483 16.1655 13.8831 12.5032 10.7565 GeneID:26271,Genbank:NM_001142522.2,HGNC:HGNC:13584,MIM:606013 F-box protein 5 GO:0000083,GO:0001556,GO:0005634,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0007057,GO:0007088,GO:0007346,GO:0016050,GO:0019901,GO:0045835,GO:0046785,GO:0046872,GO:0051301,GO:0051436,GO:0051437,GO:0051439,GO:1904668,GO:1990948 regulation of transcription involved in G1/S transition of mitotic cell cycle|oocyte maturation|nucleus|nucleoplasm|cytoplasm|spindle|cytosol|spindle assembly involved in female meiosis I|regulation of mitotic nuclear division|regulation of mitotic cell cycle|vesicle organization|protein kinase binding|negative regulation of meiotic nuclear division|microtubule polymerization|metal ion binding|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin protein ligase activity|ubiquitin ligase inhibitor activity hsa04114 Oocyte meiosis FBXO6 25.9226387175447 22.7637985532475 29.0814788818419 1.27753190285077 0.353359318959299 0.52982208279653 1 0.434949 0.335573 0.593549 0.45536 GeneID:26270,Genbank:NM_018438.5,HGNC:HGNC:13585,MIM:605647 F-box protein 6 hsa04141 Protein processing in endoplasmic reticulum FBXO7 2542.82058817737 2472.94077313265 2612.70040322209 1.05651555896844 0.0793140135400841 0.564694356570607 1 43.3065 41.9161 48.4043 43.6401 GeneID:25793,Genbank:XM_024452207.1,HGNC:HGNC:13586,MIM:605648 F-box protein 7 GO:0000151,GO:0000209,GO:0000422,GO:0004842,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006511,GO:0006626,GO:0010975,GO:0016567,GO:0019005,GO:0019901,GO:0031625,GO:0031647,GO:0040012,GO:0042787,GO:0043130,GO:0043234,GO:0043687,GO:0045620,GO:0045736,GO:0046982,GO:0097409,GO:0097414,GO:0097462,GO:1903204,GO:1903208,GO:1903599,GO:1990037,GO:1990038,GO:2000134 ubiquitin ligase complex|protein polyubiquitination|autophagy of mitochondrion|ubiquitin-protein transferase activity|nucleus|cytoplasm|mitochondrion|cytosol|ubiquitin-dependent protein catabolic process|protein targeting to mitochondrion|regulation of neuron projection development|protein ubiquitination|SCF ubiquitin ligase complex|protein kinase binding|ubiquitin protein ligase binding|regulation of protein stability|regulation of locomotion|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin binding|protein complex|post-translational protein modification|negative regulation of lymphocyte differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|protein heterodimerization activity|glial cytoplasmic inclusion|classical Lewy body|Lewy neurite|negative regulation of oxidative stress-induced neuron death|negative regulation of hydrogen peroxide-induced neuron death|positive regulation of autophagy of mitochondrion|Lewy body core|Lewy body corona|negative regulation of G1/S transition of mitotic cell cycle FBXO8 375.478004283314 343.370254632712 407.585753933917 1.18701532364792 0.247338559418039 0.186568912503876 1 4.97356 5.00998 6.36304 5.87767 GeneID:26269,Genbank:NM_012180.2,HGNC:HGNC:13587,MIM:605649 F-box protein 8 GO:0000151,GO:0005086,GO:0006511,GO:0032012 ubiquitin ligase complex|ARF guanyl-nucleotide exchange factor activity|ubiquitin-dependent protein catabolic process|regulation of ARF protein signal transduction FBXO9 1419.64945820185 1481.44858043892 1357.85033596478 0.916569332134687 -0.125684080086536 0.391230161793749 1 8.46093 8.85868 7.726 8.62475 GeneID:26268,Genbank:XM_005248995.4,HGNC:HGNC:13588,MIM:609091 F-box protein 9 GO:0000151,GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0016567,GO:0019005,GO:0031146,GO:0032006,GO:0043687,GO:0045087,GO:0045444 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of TOR signaling|post-translational protein modification|innate immune response|fat cell differentiation FBXW10 6.58517412996606 8.32140517816722 4.84894308176491 0.582707244503252 -0.779156847795839 0.545714902865092 1 0.0405216 0.0379781 0.030932 0.0144093 GeneID:10517,Genbank:NM_001267585.1,HGNC:HGNC:1211,MIM:611679 F-box and WD repeat domain containing 10 GO:0000209,GO:0004842,GO:0005829,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|post-translational protein modification FBXW11 2450.18820143893 2695.83294912557 2204.5434537523 0.817759666624513 -0.290251186578917 0.0357283444377002 0.738653561785664 13.3249 13.9729 11.2734 11.0829 GeneID:23291,Genbank:XM_005265855.5,HGNC:HGNC:13607,MIM:605651 F-box and WD repeat domain containing 11 GO:0000086,GO:0000151,GO:0000209,GO:0002223,GO:0004842,GO:0005634,GO:0005813,GO:0005829,GO:0006470,GO:0016055,GO:0016567,GO:0019005,GO:0031146,GO:0031648,GO:0038061,GO:0038095,GO:0042347,GO:0042753,GO:0043161,GO:0043687,GO:0045862,GO:0045892,GO:0045893,GO:0046983,GO:0048511,GO:0050852,GO:0051403,GO:0061630,GO:0070498 G2/M transition of mitotic cell cycle|ubiquitin ligase complex|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|ubiquitin-protein transferase activity|nucleus|centrosome|cytosol|protein dephosphorylation|Wnt signaling pathway|protein ubiquitination|SCF ubiquitin ligase complex|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|protein destabilization|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|positive regulation of circadian rhythm|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|positive regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|rhythmic process|T cell receptor signaling pathway|stress-activated MAPK cascade|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway hsa04114,hsa04120,hsa04218,hsa04310,hsa04340,hsa04390,hsa04710,hsa05131,hsa05170 Oocyte meiosis|Ubiquitin mediated proteolysis|Cellular senescence|Wnt signaling pathway|Hedgehog signaling pathway|Hippo signaling pathway|Circadian rhythm|Shigellosis|Human immunodeficiency virus 1 infection FBXW12 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.020756 0 GeneID:285231,Genbank:NM_001159927.1,HGNC:HGNC:20729,MIM:609075 F-box and WD repeat domain containing 12 GO:0000209,GO:0004842,GO:0005829,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|post-translational protein modification FBXW2 1394.67423635888 1519.53784562094 1269.81062709681 0.835655808610627 -0.259019250020432 0.0794982454795301 0.945946433581095 7.00611 6.75116 6.31373 5.20319 GeneID:26190,Genbank:NM_012164.3,HGNC:HGNC:13608,MIM:609071 F-box and WD repeat domain containing 2 GO:0000209,GO:0004842,GO:0005829,GO:0006464,GO:0006508,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|cellular protein modification process|proteolysis|post-translational protein modification FBXW4 704.977131957998 618.574592120374 791.379671795621 1.27936013194932 0.355422431103014 0.0301075320721461 0.685920673780216 8.18464 8.57089 10.7406 11.0105 GeneID:6468,Genbank:NM_001323541.1,HGNC:HGNC:10847,MIM:608071 F-box and WD repeat domain containing 4 GO:0000151,GO:0000209,GO:0002053,GO:0004842,GO:0005829,GO:0006511,GO:0016055,GO:0019005,GO:0030326,GO:0031146,GO:0042733,GO:0043687,GO:0051216 ubiquitin ligase complex|protein polyubiquitination|positive regulation of mesenchymal cell proliferation|ubiquitin-protein transferase activity|cytosol|ubiquitin-dependent protein catabolic process|Wnt signaling pathway|SCF ubiquitin ligase complex|embryonic limb morphogenesis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|embryonic digit morphogenesis|post-translational protein modification|cartilage development FBXW5 2216.93121887674 2038.42130573928 2395.44113201419 1.17514525837701 0.232839097715949 0.100774924813722 1 32.1321 33.3281 39.2611 39.7928 GeneID:54461,Genbank:NM_018998.3,HGNC:HGNC:13613,MIM:609072 F-box and WD repeat domain containing 5 GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0007088,GO:0010824,GO:0016567,GO:0019005,GO:0019901,GO:0031146,GO:0043161,GO:0043687,GO:0080008 protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|regulation of mitotic nuclear division|regulation of centrosome duplication|protein ubiquitination|SCF ubiquitin ligase complex|protein kinase binding|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|Cul4-RING E3 ubiquitin ligase complex FBXW7 163.728497888579 162.671228481956 164.785767295201 1.01299884947681 0.0186325355852098 0.928669214310288 1 0.929053 0.621028 0.811855 0.684279 GeneID:55294,Genbank:XM_011532085.2,HGNC:HGNC:16712,MIM:606278 F-box and WD repeat domain containing 7 GO:0000209,GO:0001944,GO:0004842,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006974,GO:0007062,GO:0010868,GO:0010883,GO:0016032,GO:0016567,GO:0019005,GO:0030332,GO:0030674,GO:0031146,GO:0031398,GO:0031625,GO:0032876,GO:0032880,GO:0034644,GO:0042802,GO:0043161,GO:0043234,GO:0043687,GO:0045741,GO:0045746,GO:0050816,GO:0050821,GO:0051443,GO:0055088,GO:0070374,GO:0097027,GO:1901800,GO:1902806,GO:1903146,GO:1903378,GO:1903955,GO:1990452,GO:2000060,GO:2000346,GO:2000639 protein polyubiquitination|vasculature development|ubiquitin-protein transferase activity|nucleoplasm|nucleolus|cytoplasm|cytosol|cellular response to DNA damage stimulus|sister chromatid cohesion|negative regulation of triglyceride biosynthetic process|regulation of lipid storage|viral process|protein ubiquitination|SCF ubiquitin ligase complex|cyclin binding|protein binding, bridging|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|negative regulation of DNA endoreduplication|regulation of protein localization|cellular response to UV|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein complex|post-translational protein modification|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of Notch signaling pathway|phosphothreonine residue binding|protein stabilization|positive regulation of ubiquitin-protein transferase activity|lipid homeostasis|positive regulation of ERK1 and ERK2 cascade|ubiquitin-protein transferase activator activity|positive regulation of proteasomal protein catabolic process|regulation of cell cycle G1/S phase transition|regulation of autophagy of mitochondrion|positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|positive regulation of protein targeting to mitochondrion|Parkin-FBXW7-Cul1 ubiquitin ligase complex|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of hepatocyte proliferation|negative regulation of SREBP signaling pathway hsa04120 Ubiquitin mediated proteolysis FBXW8 445.729815252009 455.29660537602 436.163025127997 0.957975570162178 -0.0619392293802601 0.739160945660094 1 2.14979 2.13114 2.11494 1.98208 GeneID:26259,Genbank:XM_017019176.1,HGNC:HGNC:13597,MIM:609073 F-box and WD repeat domain containing 8 GO:0000209,GO:0004842,GO:0005794,GO:0005829,GO:0007030,GO:0008283,GO:0016567,GO:0019005,GO:0031467,GO:0043687,GO:0048471,GO:0050775,GO:0060712,GO:0060716 protein polyubiquitination|ubiquitin-protein transferase activity|Golgi apparatus|cytosol|Golgi organization|cell proliferation|protein ubiquitination|SCF ubiquitin ligase complex|Cul7-RING ubiquitin ligase complex|post-translational protein modification|perinuclear region of cytoplasm|positive regulation of dendrite morphogenesis|spongiotrophoblast layer development|labyrinthine layer blood vessel development hsa04120 Ubiquitin mediated proteolysis FBXW9 263.645983526078 269.986039854656 257.305927197501 0.953034191456785 -0.0694001210876324 0.74761718321387 1 6.18675 6.55143 5.18498 7.12496 GeneID:84261,Genbank:XM_005260096.4,HGNC:HGNC:28136,MIM:609074 F-box and WD repeat domain containing 9 GO:0000209,GO:0004842,GO:0005829,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|post-translational protein modification FCER1G 2.80371225463067 3.67063118712625 1.93679332213509 0.527645852551974 -0.922358154302868 0.715194581525536 1 0.402756 0.183462 0 0.352631 GeneID:2207,Genbank:NM_004106.1,HGNC:HGNC:3611,MIM:147139 Fc fragment of IgE receptor Ig GO:0001798,GO:0001805,GO:0001812,GO:0002223,GO:0002283,GO:0002292,GO:0002431,GO:0002554,GO:0005886,GO:0005887,GO:0006911,GO:0007229,GO:0007596,GO:0009897,GO:0009986,GO:0010543,GO:0016064,GO:0019767,GO:0019863,GO:0019864,GO:0019886,GO:0030168,GO:0030593,GO:0031623,GO:0032733,GO:0032755,GO:0032760,GO:0032765,GO:0032998,GO:0033026,GO:0038094,GO:0038095,GO:0042590,GO:0042742,GO:0042803,GO:0043306,GO:0043312,GO:0045087,GO:0045576,GO:0050766,GO:0050900,GO:0051260,GO:0070821,GO:0071404,GO:0072659,GO:0101003 positive regulation of type IIa hypersensitivity|positive regulation of type III hypersensitivity|positive regulation of type I hypersensitivity|stimulatory C-type lectin receptor signaling pathway|neutrophil activation involved in immune response|T cell differentiation involved in immune response|Fc receptor mediated stimulatory signaling pathway|serotonin secretion by platelet|plasma membrane|integral component of plasma membrane|phagocytosis, engulfment|integrin-mediated signaling pathway|blood coagulation|external side of plasma membrane|cell surface|regulation of platelet activation|immunoglobulin mediated immune response|IgE receptor activity|IgE binding|IgG binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|platelet activation|neutrophil chemotaxis|receptor internalization|positive regulation of interleukin-10 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of mast cell cytokine production|Fc-epsilon receptor I complex|negative regulation of mast cell apoptotic process|Fc-gamma receptor signaling pathway|Fc-epsilon receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I|defense response to bacterium|protein homodimerization activity|positive regulation of mast cell degranulation|neutrophil degranulation|innate immune response|mast cell activation|positive regulation of phagocytosis|leukocyte migration|protein homooligomerization|tertiary granule membrane|cellular response to low-density lipoprotein particle stimulus|protein localization to plasma membrane|ficolin-1-rich granule membrane hsa04071,hsa04072,hsa04611,hsa04625,hsa04650,hsa04664,hsa05152,hsa05310 Sphingolipid signaling pathway|Phospholipase D signaling pathway|Platelet activation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Fc epsilon RI signaling pathway|Tuberculosis|Asthma FCF1 1178.60724879845 1275.08354494275 1082.13095265414 0.848674549166682 -0.236716681649753 0.116900136171283 1 18.0186 16.8793 14.1793 15.2491 GeneID:51077,Genbank:XM_011536815.3,HGNC:HGNC:20220 FCF1, rRNA-processing protein GO:0000447,GO:0000462,GO:0000480,GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0032040 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|nucleolus|rRNA processing|small-subunit processome hsa03008 Ribosome biogenesis in eukaryotes FCGBP 1.94103481592698 0.490071401957362 3.3919982298966 6.92143678726986 2.79107155097012 0.35751656982365 1 0 0.00358968 0.011714 0.014572 GeneID:8857,Genbank:NM_003890.2,HGNC:HGNC:13572,MIM:617553 Fc fragment of IgG binding protein GO:0070062 extracellular exosome FCGR2A 11.2259290160718 10.819788462639 11.6320695695047 1.07507365875688 0.104435509566112 0.954382655177619 1 0.0682075 0.0545328 0.0929284 0.0778689 GeneID:2212,Genbank:NM_001136219.1,HGNC:HGNC:3616,MIM:146790 Fc fragment of IgG receptor IIa GO:0005886,GO:0016021,GO:0019864,GO:0030667,GO:0038096,GO:0043312,GO:0070062 plasma membrane|integral component of membrane|IgG binding|secretory granule membrane|Fc-gamma receptor signaling pathway involved in phagocytosis|neutrophil degranulation|extracellular exosome hsa04145,hsa04380,hsa04611,hsa04666,hsa05140,hsa05150,hsa05152,hsa05322 Phagosome|Osteoclast differentiation|Platelet activation|Fc gamma R-mediated phagocytosis|Leishmaniasis|Staphylococcus aureus infection|Tuberculosis|Systemic lupus erythematosus FCGR2B 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.011266 0 GeneID:2213,Genbank:XM_024454044.1,HGNC:HGNC:3618,MIM:604590 Fc fragment of IgG receptor IIb GO:0004888,GO:0005737,GO:0005886,GO:0006955,GO:0016021,GO:0019864 transmembrane signaling receptor activity|cytoplasm|plasma membrane|immune response|integral component of membrane|IgG binding hsa04145,hsa04380,hsa04662,hsa04666,hsa05150,hsa05152,hsa05162 Phagosome|Osteoclast differentiation|B cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Staphylococcus aureus infection|Tuberculosis|Measles FCGRT 312.428374304705 281.286091064144 343.570657545265 1.22142782192141 0.288568612657402 0.143179948199674 1 5.31241 5.04373 5.9236 7.14091 GeneID:2217,Genbank:NM_001136019.2,HGNC:HGNC:3621,MIM:601437 Fc fragment of IgG receptor and transporter GO:0002416,GO:0005886,GO:0016021,GO:0019770,GO:0019864,GO:0030881 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor|plasma membrane|integral component of membrane|IgG receptor activity|IgG binding|beta-2-microglobulin binding FCHO1 17.5700922059009 20.1213364447209 15.0188479670809 0.746414037076613 -0.421951977092124 0.566101738561708 1 0.205951 0.122362 0.0950439 0.155901 GeneID:23149,Genbank:NM_001161357.1,HGNC:HGNC:29002,MIM:613437 FCH domain only 1 GO:0005654,GO:0005829,GO:0005886,GO:0005905,GO:0035612,GO:0048268,GO:0061024,GO:0072583 nucleoplasm|cytosol|plasma membrane|clathrin-coated pit|AP-2 adaptor complex binding|clathrin coat assembly|membrane organization|clathrin-dependent endocytosis FCHO2 95.2053877763601 104.123425931568 86.2873496211522 0.828702559958621 -0.271073716052975 0.625092462982162 1 0.606742 0.406165 0.570768 0.293457 GeneID:115548,Genbank:NM_138782.2,HGNC:HGNC:25180,MIM:613438 FCH domain only 2 GO:0001786,GO:0005546,GO:0005829,GO:0005886,GO:0005905,GO:0010324,GO:0030136,GO:0035091,GO:0042802,GO:0048268,GO:0048488,GO:0061024,GO:0072583,GO:0072659,GO:0098835 phosphatidylserine binding|phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|clathrin-coated pit|membrane invagination|clathrin-coated vesicle|phosphatidylinositol binding|identical protein binding|clathrin coat assembly|synaptic vesicle endocytosis|membrane organization|clathrin-dependent endocytosis|protein localization to plasma membrane|presynaptic endocytic zone membrane FCHSD1 613.829814125181 630.124583358396 597.535044891967 0.948280801404803 -0.076613766978694 0.635830795143448 1 3.64471 3.94552 3.69658 3.86261 GeneID:89848,Genbank:NM_033449.2,HGNC:HGNC:25463,MIM:617555 FCH and double SH3 domains 1 GO:0007274,GO:0030833,GO:0031594,GO:0055037 neuromuscular synaptic transmission|regulation of actin filament polymerization|neuromuscular junction|recycling endosome FCHSD2 344.162606338993 374.281953574748 314.043259103239 0.839055306043553 -0.253162186337817 0.201662742200601 1 2.75798 2.26768 2.17228 2.00214 GeneID:9873,Genbank:XM_011545409.1,HGNC:HGNC:29114,MIM:617556 FCH and double SH3 domains 2 GO:0007274,GO:0030833,GO:0031594,GO:0055037 neuromuscular synaptic transmission|regulation of actin filament polymerization|neuromuscular junction|recycling endosome FCMR 35.5010040669902 23.9938813856949 47.0081267482856 1.95917142344097 0.970243635955798 0.0448891345569421 0.789181535745318 0.230827 0.258507 0.510242 0.548281 GeneID:9214,Genbank:XM_005273351.4,HGNC:HGNC:14315,MIM:606015 Fc fragment of IgM receptor GO:0002376,GO:0005576,GO:0006968,GO:0016021,GO:0043066 immune system process|extracellular region|cellular defense response|integral component of membrane|negative regulation of apoptotic process FCRLA 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.0531594 0 0 GeneID:84824,Genbank:NM_001184866.1,HGNC:HGNC:18504,MIM:606891 Fc receptor like A GO:0005737,GO:0030154 cytoplasm|cell differentiation FCRLB 10.7177175481956 10.771762187954 10.6636729084372 0.989965497043953 -0.0145498506153273 1 1 0.274635 0.237452 0.336334 0.183914 GeneID:127943,Genbank:NM_001002901.3,HGNC:HGNC:26431,MIM:609251 Fc receptor like B GO:0005737,GO:0005783,GO:0050777 cytoplasm|endoplasmic reticulum|negative regulation of immune response FDCSP 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0878753 0 0 0 GeneID:260436,Genbank:NM_152997.3,HGNC:HGNC:19215,MIM:607241 follicular dendritic cell secreted protein GO:0005576 extracellular region FDFT1 6832.41232743213 6590.52593755772 7074.29871730653 1.07340427521754 0.102193539285528 0.448044537138013 1 50.8545 54.4873 55.5703 58.3384 GeneID:2222,Genbank:NM_001287742.1,HGNC:HGNC:3629,MIM:184420 farnesyl-diphosphate farnesyltransferase 1 GO:0004310,GO:0005783,GO:0005789,GO:0006694,GO:0006695,GO:0006696,GO:0008299,GO:0016021,GO:0016491,GO:0019216,GO:0045338,GO:0045540,GO:0051996 farnesyl-diphosphate farnesyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|steroid biosynthetic process|cholesterol biosynthetic process|ergosterol biosynthetic process|isoprenoid biosynthetic process|integral component of membrane|oxidoreductase activity|regulation of lipid metabolic process|farnesyl diphosphate metabolic process|regulation of cholesterol biosynthetic process|squalene synthase activity hsa00100 Steroid biosynthesis FDPS 3973.6805549419 3516.24728126576 4431.11382861804 1.26018265331526 0.333632855895155 0.0330056631648885 0.717059810541268 49.4587 53.5408 63.8579 70.1007 GeneID:2224,Genbank:NM_002004.3,HGNC:HGNC:3631,MIM:134629 farnesyl diphosphate synthase GO:0003723,GO:0004161,GO:0004337,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006695,GO:0016032,GO:0033384,GO:0045337,GO:0045540,GO:0046872 RNA binding|dimethylallyltranstransferase activity|geranyltranstransferase activity|nucleoplasm|cytoplasm|mitochondrion|cytosol|cholesterol biosynthetic process|viral process|geranyl diphosphate biosynthetic process|farnesyl diphosphate biosynthetic process|regulation of cholesterol biosynthetic process|metal ion binding hsa00900,hsa05164,hsa05166 Terpenoid backbone biosynthesis|Influenza A|Human T-cell leukemia virus 1 infection FDX1 457.364172881119 445.082558174925 469.645787587313 1.05518802963906 0.0775001034413725 0.677975064249854 1 6.2238 7.13933 7.75307 6.20301 GeneID:2230,Genbank:NM_004109.4,HGNC:HGNC:3638,MIM:103260 ferredoxin 1 GO:0005506,GO:0005739,GO:0005759,GO:0006700,GO:0008203,GO:0009055,GO:0016125,GO:0042446,GO:0044281,GO:0051537,GO:0071320,GO:1904322 iron ion binding|mitochondrion|mitochondrial matrix|C21-steroid hormone biosynthetic process|cholesterol metabolic process|electron transfer activity|sterol metabolic process|hormone biosynthetic process|small molecule metabolic process|2 iron, 2 sulfur cluster binding|cellular response to cAMP|cellular response to forskolin FDX1L 651.370453357704 661.633231907721 641.107674807686 0.968977439296915 -0.0454650191266414 0.799876250081931 1 23.114 25.8573 22.996 26.3685 GeneID:112812,Genbank:NM_001031734.3,HGNC:HGNC:30546,MIM:614585 ferredoxin 1 like GO:0005759,GO:0006700,GO:0009055,GO:0016125,GO:0044281,GO:0046872,GO:0051537 mitochondrial matrix|C21-steroid hormone biosynthetic process|electron transfer activity|sterol metabolic process|small molecule metabolic process|metal ion binding|2 iron, 2 sulfur cluster binding FDXACB1 74.6199470561851 82.3691961475591 66.8706979648111 0.8118410897809 -0.300730733759199 0.39422253066477 1 0.861803 1.25924 0.733844 0.916426 GeneID:91893,Genbank:NM_138378.2,HGNC:HGNC:25110 ferredoxin-fold anticodon binding domain containing 1 GO:0004826,GO:0006432,GO:0009328 phenylalanine-tRNA ligase activity|phenylalanyl-tRNA aminoacylation|phenylalanine-tRNA ligase complex FDXR 405.854762141313 413.881684583924 397.827839698703 0.961211511687549 -0.0570741682723829 0.802516942982934 1 2.48584 2.66669 2.63849 3.05431 GeneID:2232,Genbank:NM_001258014.3,HGNC:HGNC:3642,MIM:103270 ferredoxin reductase FECH 464.171079624186 452.952109570711 475.39004967766 1.04953711359952 0.0697531839328506 0.698723919116865 1 2.08299 2.06992 2.15157 2.32769 GeneID:2235,Genbank:NM_000140.3,HGNC:HGNC:3647,MIM:612386 ferrochelatase hsa00860 Porphyrin and chlorophyll metabolism FEM1A 1586.36918539257 1591.38725361078 1581.35111717436 0.993693466870714 -0.00912721495926074 0.936844126083086 1 18.7555 19.2405 19.8094 18.6767 GeneID:55527,Genbank:NM_018708.2,HGNC:HGNC:16934,MIM:613538 fem-1 homolog A GO:0004842,GO:0005829,GO:0031867,GO:0043687,GO:0050728,GO:0051438 ubiquitin-protein transferase activity|cytosol|EP4 subtype prostaglandin E2 receptor binding|post-translational protein modification|negative regulation of inflammatory response|regulation of ubiquitin-protein transferase activity FEM1B 722.575754926506 805.411172775695 639.740337077317 0.794302784343773 -0.332239034367026 0.0505937734993679 0.824323373719101 5.67771 4.96516 4.56891 3.93305 GeneID:10116,Genbank:NM_015322.4,HGNC:HGNC:3649,MIM:613539 fem-1 homolog B GO:0004842,GO:0005123,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0043687,GO:0051438,GO:0060442,GO:0060743,GO:1902041,GO:2000001 ubiquitin-protein transferase activity|death receptor binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|post-translational protein modification|regulation of ubiquitin-protein transferase activity|branching involved in prostate gland morphogenesis|epithelial cell maturation involved in prostate gland development|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of DNA damage checkpoint FEM1C 408.080431084253 424.047705510335 392.113156658171 0.924691141026855 -0.112956527871325 0.567237270451582 1 3.39464 3.29091 3.494 2.62249 GeneID:56929,Genbank:XM_017009647.2,HGNC:HGNC:16933,MIM:608767 fem-1 homolog C GO:0005654,GO:0005829,GO:0016567,GO:0043687 nucleoplasm|cytosol|protein ubiquitination|post-translational protein modification FEN1 3690.08393041113 3806.60358059282 3573.56428022944 0.93878025504114 -0.091140596287671 0.493467206474811 1 67.5959 68.9819 64.8482 65.2632 GeneID:2237,Genbank:NM_004111.5,HGNC:HGNC:3650,MIM:600393 flap structure-specific endonuclease 1 hsa03030,hsa03410,hsa03450 DNA replication|Base excision repair|Non-homologous end-joining FER 115.878657730286 124.148709826919 107.608605633653 0.866771839865871 -0.206275811720887 0.634161014729577 1 0.305886 0.203252 0.236132 0.1703 GeneID:2241,Genbank:XM_011543267.2,HGNC:HGNC:3655,MIM:176942 FER tyrosine kinase GO:0000226,GO:0000278,GO:0001932,GO:0004713,GO:0004715,GO:0005154,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005938,GO:0006468,GO:0006935,GO:0007155,GO:0007260,GO:0008157,GO:0008283,GO:0008284,GO:0008289,GO:0010591,GO:0010762,GO:0018108,GO:0019221,GO:0030054,GO:0030154,GO:0030335,GO:0030838,GO:0031234,GO:0031532,GO:0032496,GO:0032869,GO:0033007,GO:0034446,GO:0034614,GO:0035426,GO:0035556,GO:0036006,GO:0036119,GO:0038028,GO:0038083,GO:0038095,GO:0038109,GO:0042058,GO:0042995,GO:0043304,GO:0044331,GO:0045087,GO:0046777,GO:0048008,GO:0050904,GO:0051092,GO:0070102 microtubule cytoskeleton organization|mitotic cell cycle|regulation of protein phosphorylation|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|epidermal growth factor receptor binding|ATP binding|nucleus|cytoplasm|cytosol|cytoskeleton|cell cortex|protein phosphorylation|chemotaxis|cell adhesion|tyrosine phosphorylation of STAT protein|protein phosphatase 1 binding|cell proliferation|positive regulation of cell proliferation|lipid binding|regulation of lamellipodium assembly|regulation of fibroblast migration|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|cell junction|cell differentiation|positive regulation of cell migration|positive regulation of actin filament polymerization|extrinsic component of cytoplasmic side of plasma membrane|actin cytoskeleton reorganization|response to lipopolysaccharide|cellular response to insulin stimulus|negative regulation of mast cell activation involved in immune response|substrate adhesion-dependent cell spreading|cellular response to reactive oxygen species|extracellular matrix-cell signaling|intracellular signal transduction|cellular response to macrophage colony-stimulating factor stimulus|response to platelet-derived growth factor|insulin receptor signaling pathway via phosphatidylinositol 3-kinase|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|Kit signaling pathway|regulation of epidermal growth factor receptor signaling pathway|cell projection|regulation of mast cell degranulation|cell-cell adhesion mediated by cadherin|innate immune response|protein autophosphorylation|platelet-derived growth factor receptor signaling pathway|diapedesis|positive regulation of NF-kappaB transcription factor activity|interleukin-6-mediated signaling pathway hsa04520 Adherens junction FER1L5 6.52496672640724 6.26506702096788 6.7848664318466 1.08296789310299 0.114990471803372 0.978315272999552 1 0.0208364 0.00372791 0.0195527 0 GeneID:90342,Genbank:XM_011512122.2,HGNC:HGNC:19044 fer-1 like family member 5 GO:0005886,GO:0007520,GO:0016021 plasma membrane|myoblast fusion|integral component of membrane FER1L6 1.70187218637189 0.980142803914724 2.42360156882906 2.47270250737863 1.30608867848779 0.73299311284869 1 0 0.00375891 0.00385491 0.00717419 GeneID:654463,Genbank:NM_001039112.2,HGNC:HGNC:28065 fer-1 like family member 6 GO:0016021 integral component of membrane FERMT1 87.5735736743014 112.628144554222 62.5190027943809 0.555092184478657 -0.849200714332022 0.00650199292300523 0.318458466834409 0.674976 0.967402 0.474829 0.435243 GeneID:55612,Genbank:XM_024451935.1,HGNC:HGNC:15889,MIM:607900 fermitin family member 1 GO:0001954,GO:0005829,GO:0005925,GO:0007155,GO:0010629,GO:0030054,GO:0030511,GO:0031941,GO:0032587,GO:0033630,GO:0035414,GO:0043616,GO:0051546,GO:0051886,GO:0071711,GO:0090090,GO:0090162,GO:2000647,GO:2001203 positive regulation of cell-matrix adhesion|cytosol|focal adhesion|cell adhesion|negative regulation of gene expression|cell junction|positive regulation of transforming growth factor beta receptor signaling pathway|filamentous actin|ruffle membrane|positive regulation of cell adhesion mediated by integrin|negative regulation of catenin import into nucleus|keratinocyte proliferation|keratinocyte migration|negative regulation of timing of anagen|basement membrane organization|negative regulation of canonical Wnt signaling pathway|establishment of epithelial cell polarity|negative regulation of stem cell proliferation|positive regulation of transforming growth factor-beta secretion FERMT2 704.642163230082 814.174623081134 595.109703379031 0.730936197847728 -0.452182613560372 0.00839224932176146 0.356525902221039 7.21209 6.04631 4.80107 4.92983 GeneID:10979,Genbank:NM_006832.2,HGNC:HGNC:15767,MIM:607746 fermitin family member 2 FERMT3 8.22803550438413 7.73528122683997 8.72078978192829 1.12740436012446 0.173005052082429 0.921679166791937 1 0.0504052 0.0430309 0.0310057 0.101307 GeneID:83706,Genbank:XM_011545294.3,HGNC:HGNC:23151,MIM:607901 fermitin family member 3 GO:0002102,GO:0002576,GO:0005178,GO:0005576,GO:0007159,GO:0007229,GO:0016020,GO:0030054,GO:0030335,GO:0031093,GO:0033622,GO:0033632,GO:0034446,GO:0042995,GO:0070062,GO:0070527 podosome|platelet degranulation|integrin binding|extracellular region|leukocyte cell-cell adhesion|integrin-mediated signaling pathway|membrane|cell junction|positive regulation of cell migration|platelet alpha granule lumen|integrin activation|regulation of cell-cell adhesion mediated by integrin|substrate adhesion-dependent cell spreading|cell projection|extracellular exosome|platelet aggregation hsa04611 Platelet activation FES 2.70852967731418 3.47852608838648 1.93853326624189 0.557285820771601 -0.843510648025679 0.718054104677464 1 0.0171604 0.0587543 0.0316353 0.0294595 GeneID:2242,Genbank:XM_017022008.1,HGNC:HGNC:3657,MIM:190030 FES proto-oncogene, tyrosine kinase GO:0001578,GO:0004713,GO:0004715,GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0005925,GO:0006468,GO:0006935,GO:0007098,GO:0007173,GO:0007275,GO:0008017,GO:0008283,GO:0008360,GO:0010976,GO:0015630,GO:0016477,GO:0018108,GO:0030155,GO:0031116,GO:0031234,GO:0031410,GO:0034987,GO:0035091,GO:0038083,GO:0042127,GO:0043304,GO:0045087,GO:0045595,GO:0045639,GO:0046777,GO:0060627,GO:2000145,GO:2000251 microtubule bundle formation|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|ATP binding|cytoplasm|Golgi apparatus|cytosol|focal adhesion|protein phosphorylation|chemotaxis|centrosome cycle|epidermal growth factor receptor signaling pathway|multicellular organism development|microtubule binding|cell proliferation|regulation of cell shape|positive regulation of neuron projection development|microtubule cytoskeleton|cell migration|peptidyl-tyrosine phosphorylation|regulation of cell adhesion|positive regulation of microtubule polymerization|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|immunoglobulin receptor binding|phosphatidylinositol binding|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|regulation of mast cell degranulation|innate immune response|regulation of cell differentiation|positive regulation of myeloid cell differentiation|protein autophosphorylation|regulation of vesicle-mediated transport|regulation of cell motility|positive regulation of actin cytoskeleton reorganization hsa04360 Axon guidance FETUB 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0 0 0 0 GeneID:26998,Genbank:XM_011512681.2,HGNC:HGNC:3658,MIM:605954 fetuin B GO:0004869,GO:0005576,GO:0007338,GO:0007339,GO:0008191,GO:0010951,GO:0070062 cysteine-type endopeptidase inhibitor activity|extracellular region|single fertilization|binding of sperm to zona pellucida|metalloendopeptidase inhibitor activity|negative regulation of endopeptidase activity|extracellular exosome FEV 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0379762 GeneID:54738,Genbank:NM_017521.2,HGNC:HGNC:18562,MIM:607150 FEV, ETS transcription factor GO:0000981,GO:0003700,GO:0003714,GO:0005634,GO:0006357,GO:0006366,GO:0010628,GO:0016607,GO:0030154,GO:0042551,GO:0043565,GO:0048665 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|positive regulation of gene expression|nuclear speck|cell differentiation|neuron maturation|sequence-specific DNA binding|neuron fate specification hsa05202 Transcriptional misregulation in cancer FEZ1 607.984514007097 518.11097171997 697.858056294225 1.34692777104787 0.429672488406025 0.00987138452099823 0.395250236220769 4.74093 4.12629 5.81403 5.62391 GeneID:9638,Genbank:NM_005103.4,HGNC:HGNC:3659,MIM:604825 fasciculation and elongation protein zeta 1 GO:0005080,GO:0005739,GO:0005794,GO:0005813,GO:0005874,GO:0005886,GO:0007155,GO:0007399,GO:0007411,GO:0010976,GO:0021766,GO:0030010,GO:0030424,GO:0030425,GO:0030426,GO:0043015,GO:0043025,GO:0047485,GO:0051654,GO:0061881,GO:0070584,GO:0071363,GO:1902902 protein kinase C binding|mitochondrion|Golgi apparatus|centrosome|microtubule|plasma membrane|cell adhesion|nervous system development|axon guidance|positive regulation of neuron projection development|hippocampus development|establishment of cell polarity|axon|dendrite|growth cone|gamma-tubulin binding|neuronal cell body|protein N-terminus binding|establishment of mitochondrion localization|positive regulation of anterograde axonal transport of mitochondrion|mitochondrion morphogenesis|cellular response to growth factor stimulus|negative regulation of autophagosome assembly FEZ2 2127.77087034177 2162.89333983133 2092.64840085222 0.967522698560539 -0.0476325868948202 0.748894392773778 1 33.6494 32.3982 33.8168 31.1779 GeneID:9637,Genbank:XM_006712153.2,HGNC:HGNC:3660,MIM:604826 fasciculation and elongation protein zeta 2 GO:0005737,GO:0007165,GO:0007399,GO:0007411,GO:0030424,GO:1902902 cytoplasm|signal transduction|nervous system development|axon guidance|axon|negative regulation of autophagosome assembly FEZF1 20.706962670457 21.5435243759081 19.870400965006 0.922337525573436 -0.116633299371488 0.890451611588398 1 0.201232 0.192665 0.177439 0.207419 GeneID:389549,Genbank:XM_011516202.2,HGNC:HGNC:22788,MIM:613301 FEZ family zinc finger 1 GO:0000978,GO:0001078,GO:0001764,GO:0005634,GO:0005829,GO:0006351,GO:0007411,GO:0008285,GO:0021772,GO:0021797,GO:0043697,GO:0045666,GO:0045893,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|neuron migration|nucleus|cytosol|transcription, DNA-templated|axon guidance|negative regulation of cell proliferation|olfactory bulb development|forebrain anterior/posterior pattern specification|cell dedifferentiation|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|metal ion binding FFAR4 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00964305 GeneID:338557,Genbank:XM_011539746.3,HGNC:HGNC:19061,MIM:609044 free fatty acid receptor 4 GO:0004930,GO:0005504,GO:0005886,GO:0005887,GO:0007186,GO:0008527,GO:0010827,GO:0030139,GO:0043066,GO:0045444,GO:0046879,GO:0050710,GO:0050728,GO:0070374 G-protein coupled receptor activity|fatty acid binding|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|taste receptor activity|regulation of glucose transport|endocytic vesicle|negative regulation of apoptotic process|fat cell differentiation|hormone secretion|negative regulation of cytokine secretion|negative regulation of inflammatory response|positive regulation of ERK1 and ERK2 cascade FGB 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00960272 0 GeneID:2244,Genbank:NM_005141.4,HGNC:HGNC:3662,MIM:134830 fibrinogen beta chain hsa04610,hsa04611 Complement and coagulation cascades|Platelet activation FGD1 387.974538652386 384.362747607751 391.586329697021 1.01879365816336 0.026861884193976 0.898247364002476 1 3.34443 3.51699 3.52112 3.31478 GeneID:2245,Genbank:NM_004463.2,HGNC:HGNC:3663,MIM:300546 FYVE, RhoGEF and PH domain containing 1 GO:0001726,GO:0005085,GO:0005089,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0007010,GO:0007165,GO:0007186,GO:0007275,GO:0008360,GO:0009887,GO:0030027,GO:0030036,GO:0031267,GO:0035023,GO:0043065,GO:0043087,GO:0046847,GO:0046872,GO:0051056 ruffle|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|cytoskeleton organization|signal transduction|G-protein coupled receptor signaling pathway|multicellular organism development|regulation of cell shape|animal organ morphogenesis|lamellipodium|actin cytoskeleton organization|small GTPase binding|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of GTPase activity|filopodium assembly|metal ion binding|regulation of small GTPase mediated signal transduction hsa04810 Regulation of actin cytoskeleton FGD2 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0156113 0 GeneID:221472,Genbank:NM_173558.3,HGNC:HGNC:3664,MIM:605091 FYVE, RhoGEF and PH domain containing 2 GO:0001726,GO:0005085,GO:0005089,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0007010,GO:0007186,GO:0008360,GO:0030027,GO:0030036,GO:0031267,GO:0031901,GO:0032587,GO:0035023,GO:0043065,GO:0043087,GO:0043507,GO:0046847,GO:0046872,GO:0051056,GO:1901981 ruffle|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|nucleus|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|cytoskeleton organization|G-protein coupled receptor signaling pathway|regulation of cell shape|lamellipodium|actin cytoskeleton organization|small GTPase binding|early endosome membrane|ruffle membrane|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of GTPase activity|positive regulation of JUN kinase activity|filopodium assembly|metal ion binding|regulation of small GTPase mediated signal transduction|phosphatidylinositol phosphate binding FGD3 3.5544578738005 3.71865746181119 3.39025828578981 0.911688780320887 -0.133386673693425 1 1 0.0398801 0.0086875 0 0.0259159 GeneID:89846,Genbank:NM_001083536.1,HGNC:HGNC:16027,MIM:617554 FYVE, RhoGEF and PH domain containing 3 GO:0001726,GO:0005085,GO:0005089,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0007010,GO:0007186,GO:0008360,GO:0030027,GO:0030036,GO:0031267,GO:0035023,GO:0043065,GO:0043087,GO:0046847,GO:0046872,GO:0051056 ruffle|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|cytoskeleton organization|G-protein coupled receptor signaling pathway|regulation of cell shape|lamellipodium|actin cytoskeleton organization|small GTPase binding|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of GTPase activity|filopodium assembly|metal ion binding|regulation of small GTPase mediated signal transduction hsa04810 Regulation of actin cytoskeleton FGD4 26.3727222517153 26.0884371624712 26.6570073409594 1.02179395319648 0.031104303250657 0.957923003796612 1 0.114754 0.0406385 0.0848789 0.0686388 GeneID:121512,Genbank:XM_005253304.4,HGNC:HGNC:19125,MIM:611104 FYVE, RhoGEF and PH domain containing 4 GO:0001726,GO:0003779,GO:0005085,GO:0005089,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0007010,GO:0007186,GO:0008360,GO:0030027,GO:0030036,GO:0030175,GO:0031267,GO:0035023,GO:0043065,GO:0043087,GO:0046847,GO:0046872,GO:0051056 ruffle|actin binding|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytosol|cytoskeleton|cytoskeleton organization|G-protein coupled receptor signaling pathway|regulation of cell shape|lamellipodium|actin cytoskeleton organization|filopodium|small GTPase binding|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of GTPase activity|filopodium assembly|metal ion binding|regulation of small GTPase mediated signal transduction FGD5 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0057185 0 0 GeneID:152273,Genbank:NM_152536.3,HGNC:HGNC:19117,MIM:614788 FYVE, RhoGEF and PH domain containing 5 GO:0001726,GO:0005085,GO:0005089,GO:0005737,GO:0005769,GO:0005783,GO:0005794,GO:0005856,GO:0007010,GO:0008360,GO:0030027,GO:0030036,GO:0031267,GO:0032587,GO:0035023,GO:0043087,GO:0046847,GO:0046872 ruffle|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytoplasm|early endosome|endoplasmic reticulum|Golgi apparatus|cytoskeleton|cytoskeleton organization|regulation of cell shape|lamellipodium|actin cytoskeleton organization|small GTPase binding|ruffle membrane|regulation of Rho protein signal transduction|regulation of GTPase activity|filopodium assembly|metal ion binding FGD6 31.432293234183 33.2954293677768 29.5691571005892 0.888084570827195 -0.171231026303634 0.757527243808858 1 0.117068 0.133222 0.141895 0.0738424 GeneID:55785,Genbank:NM_018351.3,HGNC:HGNC:21740,MIM:613520 FYVE, RhoGEF and PH domain containing 6 GO:0001726,GO:0005085,GO:0005089,GO:0005737,GO:0005794,GO:0005856,GO:0007010,GO:0008360,GO:0030027,GO:0030036,GO:0031267,GO:0035023,GO:0043087,GO:0046847,GO:0046872 ruffle|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytoskeleton|cytoskeleton organization|regulation of cell shape|lamellipodium|actin cytoskeleton organization|small GTPase binding|regulation of Rho protein signal transduction|regulation of GTPase activity|filopodium assembly|metal ion binding FGF1 12.4596763741704 10.3777433353665 14.5416094129743 1.40123039692239 0.486694190007914 0.564363082266488 1 0.0840222 0.0501626 0.109427 0.0747718 GeneID:2246,Genbank:NM_033137.3,HGNC:HGNC:3665,MIM:131220 fibroblast growth factor 1 hsa04010,hsa04014,hsa04015,hsa04151,hsa04390,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Hippo signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF10 2.97257541626514 3.03648096111406 2.90866987141623 0.957908153769244 -0.062040760902852 1 1 0.0163899 0.0316578 0.0315736 0.0147055 GeneID:2255,Genbank:XM_005248264.4,HGNC:HGNC:3666,MIM:602115 fibroblast growth factor 10 hsa04010,hsa04014,hsa04015,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF11 97.1426872525389 91.0650028680979 103.22037163698 1.13348013381703 0.180759105595846 0.548755698858799 1 1.06019 0.946687 1.06399 1.23659 GeneID:2256,Genbank:NM_004112.3,HGNC:HGNC:3667,MIM:601514 fibroblast growth factor 11 FGF12 1275.77432192735 1121.73246475224 1429.81617910247 1.27464990452806 0.350101050725193 0.0743774021832748 0.938990486715004 6.36017 6.21254 9.38406 6.757 GeneID:2257,Genbank:NM_004113.5,HGNC:HGNC:3668,MIM:601513 fibroblast growth factor 12 GO:0003254,GO:0005634,GO:0007254,GO:0007268,GO:0008083,GO:0008201,GO:0008344,GO:0010765,GO:0017080,GO:0044325,GO:0050905,GO:0098908,GO:1902305,GO:1905150,GO:2000649,GO:2001258 regulation of membrane depolarization|nucleus|JNK cascade|chemical synaptic transmission|growth factor activity|heparin binding|adult locomotory behavior|positive regulation of sodium ion transport|sodium channel regulator activity|ion channel binding|neuromuscular process|regulation of neuronal action potential|regulation of sodium ion transmembrane transport|regulation of voltage-gated sodium channel activity|regulation of sodium ion transmembrane transporter activity|negative regulation of cation channel activity FGF13 456.714870478395 462.225248588324 451.204492368466 0.976157173902732 -0.0348146358759552 0.837145650981173 1 4.54146 4.8665 4.98944 4.38114 GeneID:2258,Genbank:XM_005262399.1,HGNC:HGNC:3670,MIM:300070 fibroblast growth factor 13 FGF14 3.2378177468211 3.084507235799 3.3911282578432 1.09940680912839 0.136725319785145 1 1 0.0165259 0.0233931 0.00791246 0.0368001 GeneID:2259,Genbank:NM_001321947.1,HGNC:HGNC:3671,MIM:601515 fibroblast growth factor 14 GO:0005576,GO:0005622,GO:0005634,GO:0007165,GO:0007254,GO:0007267,GO:0007399,GO:0008083,GO:0008201,GO:0048167,GO:0060078,GO:1901843,GO:1903421 extracellular region|intracellular|nucleus|signal transduction|JNK cascade|cell-cell signaling|nervous system development|growth factor activity|heparin binding|regulation of synaptic plasticity|regulation of postsynaptic membrane potential|positive regulation of high voltage-gated calcium channel activity|regulation of synaptic vesicle recycling FGF18 8.02800367675718 10.7237359132691 5.33227144024528 0.497240092759778 -1.00798546846128 0.343635846455038 1 0.207841 0.204578 0.150283 0.0802368 GeneID:8817,Genbank:NM_003862.2,HGNC:HGNC:3674,MIM:603726 fibroblast growth factor 18 GO:0000165,GO:0001525,GO:0001957,GO:0001958,GO:0002063,GO:0004713,GO:0005088,GO:0005105,GO:0005111,GO:0005576,GO:0005615,GO:0005730,GO:0007165,GO:0007267,GO:0008083,GO:0008284,GO:0008543,GO:0009653,GO:0016303,GO:0030324,GO:0030949,GO:0032332,GO:0043406,GO:0043536,GO:0045766,GO:0046934,GO:0051897,GO:0070374,GO:2000546 MAPK cascade|angiogenesis|intramembranous ossification|endochondral ossification|chondrocyte development|protein tyrosine kinase activity|Ras guanyl-nucleotide exchange factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding|extracellular region|extracellular space|nucleolus|signal transduction|cell-cell signaling|growth factor activity|positive regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|anatomical structure morphogenesis|1-phosphatidylinositol-3-kinase activity|lung development|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of chondrocyte differentiation|positive regulation of MAP kinase activity|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of endothelial cell chemotaxis to fibroblast growth factor hsa04010,hsa04014,hsa04015,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF2 784.264175308005 809.523849090093 759.004501525917 0.937593750176773 -0.0929651418283822 0.673446731893394 1 6.56387 5.78421 6.60627 5.01139 GeneID:2247,Genbank:NM_002006.4,HGNC:HGNC:3676,MIM:134920 fibroblast growth factor 2 hsa01521,hsa04010,hsa04014,hsa04015,hsa04151,hsa04550,hsa04810,hsa05167,hsa05200,hsa05205,hsa05218,hsa05224,hsa05226 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|Melanoma|Breast cancer|Gastric cancer FGF20 1.21974041949651 1.47021420587209 0.969266633120943 0.659268989001506 -0.60106087408571 0.974346500689373 1 0 0.0475014 0.0485319 0.0452284 GeneID:26281,Genbank:NM_019851.2,HGNC:HGNC:3677,MIM:605558 fibroblast growth factor 20 hsa04010,hsa04014,hsa04015,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF21 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0290771 0.0305914 0 GeneID:26291,Genbank:NM_019113.3,HGNC:HGNC:3678,MIM:609436 fibroblast growth factor 21 hsa04010,hsa04014,hsa04015,hsa04151,hsa04714,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Thermogenesis|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF22 1.72338377402927 0.538097676642304 2.90866987141623 5.40546818482128 2.43441957978558 0.443348663852686 1 0.134905 0 0.248779 0 GeneID:27006,Genbank:NM_001300812.1,HGNC:HGNC:3679,MIM:605831 fibroblast growth factor 22 hsa04010,hsa04014,hsa04015,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF5 125.853428492457 114.540403887366 137.166453097548 1.19753771108081 0.260071087888494 0.405325742323087 1 0.724286 0.972631 1.12732 0.862623 GeneID:2250,Genbank:NM_004464.3,HGNC:HGNC:3683,MIM:165190 fibroblast growth factor 5 hsa04010,hsa04014,hsa04015,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF6 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0165814 GeneID:2251,Genbank:NM_020996.2,HGNC:HGNC:3684,MIM:134921 fibroblast growth factor 6 hsa04010,hsa04014,hsa04015,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF7 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0107169 0.00997836 GeneID:2252,Genbank:NM_002009.3,HGNC:HGNC:3685,MIM:148180 fibroblast growth factor 7 GO:0000165,GO:0004713,GO:0005088,GO:0005104,GO:0005576,GO:0005794,GO:0007165,GO:0008083,GO:0008201,GO:0008284,GO:0008543,GO:0008544,GO:0009611,GO:0010463,GO:0010838,GO:0016303,GO:0031069,GO:0031532,GO:0034394,GO:0042056,GO:0045893,GO:0046934,GO:0050679,GO:0050731,GO:0050918,GO:0051549,GO:0051781,GO:0051897,GO:0060445,GO:0060501,GO:0060665,GO:0061033 MAPK cascade|protein tyrosine kinase activity|Ras guanyl-nucleotide exchange factor activity|fibroblast growth factor receptor binding|extracellular region|Golgi apparatus|signal transduction|growth factor activity|heparin binding|positive regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|epidermis development|response to wounding|mesenchymal cell proliferation|positive regulation of keratinocyte proliferation|1-phosphatidylinositol-3-kinase activity|hair follicle morphogenesis|actin cytoskeleton reorganization|protein localization to cell surface|chemoattractant activity|positive regulation of transcription, DNA-templated|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|positive regulation of epithelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of keratinocyte migration|positive regulation of cell division|positive regulation of protein kinase B signaling|branching involved in salivary gland morphogenesis|positive regulation of epithelial cell proliferation involved in lung morphogenesis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling|secretion by lung epithelial cell involved in lung growth hsa04010,hsa04014,hsa04015,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF8 1.02316597922947 1.07619535328461 0.97013660517434 0.901450282435646 -0.149680169798226 1 1 0.118459 0 0.108223 0 GeneID:2253,Genbank:NM_001206389.1,HGNC:HGNC:3686,MIM:600483 fibroblast growth factor 8 GO:0000165,GO:0001569,GO:0001656,GO:0001658,GO:0001759,GO:0001822,GO:0001839,GO:0001947,GO:0001974,GO:0003007,GO:0003148,GO:0003151,GO:0003198,GO:0005105,GO:0005111,GO:0005615,GO:0005622,GO:0006915,GO:0007368,GO:0007507,GO:0008078,GO:0008083,GO:0008284,GO:0008406,GO:0008543,GO:0009792,GO:0010628,GO:0021537,GO:0021543,GO:0021544,GO:0021798,GO:0021846,GO:0023019,GO:0030324,GO:0030509,GO:0030539,GO:0030878,GO:0030916,GO:0030917,GO:0035050,GO:0035108,GO:0035116,GO:0035909,GO:0042472,GO:0042476,GO:0042487,GO:0043066,GO:0043524,GO:0045165,GO:0045840,GO:0046622,GO:0048699,GO:0048853,GO:0051781,GO:0055026,GO:0060037,GO:0060070,GO:0060128,GO:0060129,GO:0060348,GO:0060425,GO:0060445,GO:0060563,GO:0070374,GO:0071542,GO:0090134 MAPK cascade|branching involved in blood vessel morphogenesis|metanephros development|branching involved in ureteric bud morphogenesis|organ induction|kidney development|neural plate morphogenesis|heart looping|blood vessel remodeling|heart morphogenesis|outflow tract septum morphogenesis|outflow tract morphogenesis|epithelial to mesenchymal transition involved in endocardial cushion formation|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding|extracellular space|intracellular|apoptotic process|determination of left/right symmetry|heart development|mesodermal cell migration|growth factor activity|positive regulation of cell proliferation|gonad development|fibroblast growth factor receptor signaling pathway|embryo development ending in birth or egg hatching|positive regulation of gene expression|telencephalon development|pallium development|subpallium development|forebrain dorsal/ventral pattern formation|cell proliferation in forebrain|signal transduction involved in regulation of gene expression|lung development|BMP signaling pathway|male genitalia development|thyroid gland development|otic vesicle formation|midbrain-hindbrain boundary development|embryonic heart tube development|limb morphogenesis|embryonic hindlimb morphogenesis|aorta morphogenesis|inner ear morphogenesis|odontogenesis|regulation of odontogenesis of dentin-containing tooth|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|cell fate commitment|positive regulation of mitotic nuclear division|positive regulation of organ growth|generation of neurons|forebrain morphogenesis|positive regulation of cell division|negative regulation of cardiac muscle tissue development|pharyngeal system development|canonical Wnt signaling pathway|corticotropin hormone secreting cell differentiation|thyroid-stimulating hormone-secreting cell differentiation|bone development|lung morphogenesis|branching involved in salivary gland morphogenesis|neuroepithelial cell differentiation|positive regulation of ERK1 and ERK2 cascade|dopaminergic neuron differentiation|cell migration involved in mesendoderm migration hsa04010,hsa04014,hsa04015,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGF9 7.09295061181561 8.36943145285216 5.81646977077905 0.694965936879368 -0.52498582769803 0.701099029101449 1 0.114752 0.0499159 0.0601657 0.0466596 GeneID:2254,Genbank:NM_002010.2,HGNC:HGNC:3687,MIM:600921 fibroblast growth factor 9 GO:0000122,GO:0001525,GO:0001649,GO:0001654,GO:0002053,GO:0002062,GO:0005104,GO:0005604,GO:0005615,GO:0005737,GO:0006606,GO:0007267,GO:0008083,GO:0008201,GO:0008284,GO:0008543,GO:0008584,GO:0010628,GO:0021762,GO:0030178,GO:0030238,GO:0030324,GO:0030326,GO:0030949,GO:0032927,GO:0042472,GO:0043410,GO:0045880,GO:0048505,GO:0048566,GO:0048706,GO:0050679,GO:0051781,GO:0060045,GO:0060484,GO:0070062,GO:0090263 negative regulation of transcription from RNA polymerase II promoter|angiogenesis|osteoblast differentiation|eye development|positive regulation of mesenchymal cell proliferation|chondrocyte differentiation|fibroblast growth factor receptor binding|basement membrane|extracellular space|cytoplasm|protein import into nucleus|cell-cell signaling|growth factor activity|heparin binding|positive regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|male gonad development|positive regulation of gene expression|substantia nigra development|negative regulation of Wnt signaling pathway|male sex determination|lung development|embryonic limb morphogenesis|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of activin receptor signaling pathway|inner ear morphogenesis|positive regulation of MAPK cascade|positive regulation of smoothened signaling pathway|regulation of timing of cell differentiation|embryonic digestive tract development|embryonic skeletal system development|positive regulation of epithelial cell proliferation|positive regulation of cell division|positive regulation of cardiac muscle cell proliferation|lung-associated mesenchyme development|extracellular exosome|positive regulation of canonical Wnt signaling pathway hsa04010,hsa04014,hsa04015,hsa04151,hsa04810,hsa05200,hsa05218,hsa05224,hsa05226 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer|Melanoma|Breast cancer|Gastric cancer FGFBP1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0256477 0 0 GeneID:9982,Genbank:NM_005130.4,HGNC:HGNC:19695,MIM:607737 fibroblast growth factor binding protein 1 GO:0005576,GO:0005615,GO:0005886,GO:0007165,GO:0007267,GO:0008201,GO:0008284,GO:0008285,GO:0008543,GO:0009986,GO:0017134,GO:0045743 extracellular region|extracellular space|plasma membrane|signal transduction|cell-cell signaling|heparin binding|positive regulation of cell proliferation|negative regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|cell surface|fibroblast growth factor binding|positive regulation of fibroblast growth factor receptor signaling pathway FGFBP2 3.42514759392606 2.00831188251439 4.84198330533773 2.41097179551395 1.26961477383129 0.672691324802854 1 0.034836 0.0928178 0 0.302084 GeneID:83888,Genbank:NM_031950.3,HGNC:HGNC:29451,MIM:607713 fibroblast growth factor binding protein 2 GO:0005615,GO:0019838 extracellular space|growth factor binding FGFBP3 129.763368227992 103.960746798152 155.565989657831 1.49639161365275 0.581487785612778 0.0329551767095783 0.717059810541268 1.90735 2.54023 3.42814 3.25391 GeneID:143282,Genbank:NM_152429.4,HGNC:HGNC:23428 fibroblast growth factor binding protein 3 GO:0005576,GO:0008201,GO:0017134,GO:0031012,GO:0043117,GO:0045743 extracellular region|heparin binding|fibroblast growth factor binding|extracellular matrix|positive regulation of vascular permeability|positive regulation of fibroblast growth factor receptor signaling pathway FGFR1 2141.52746655708 1961.19193798387 2321.86299513028 1.18390400763996 0.243552110260769 0.0837658020528489 0.963076417285947 8.20168 8.53164 10.4112 9.79537 GeneID:2260,Genbank:NM_001354368.1,HGNC:HGNC:3688,MIM:136350 fibroblast growth factor receptor 1 hsa04010,hsa04014,hsa04015,hsa04151,hsa04520,hsa04550,hsa04714,hsa04810,hsa04928,hsa05200,hsa05205,hsa05215,hsa05218,hsa05224,hsa05230 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Thermogenesis|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Proteoglycans in cancer|Prostate cancer|Melanoma|Breast cancer|Central carbon metabolism in cancer FGFR1OP 489.532695398955 505.080957620969 473.984433176942 0.938432593874658 -0.0916749726071351 0.614449887920528 1 5.35344 5.14853 5.41144 4.66409 GeneID:11116,Genbank:NM_007045.3,HGNC:HGNC:17012,MIM:605392 FGFR1 oncogene partner FGFR1OP2 293.141254070265 301.801446361452 284.481061779077 0.942610001405918 -0.0852671059782177 0.681461443516846 1 3.7995 3.87722 3.78086 3.55859 GeneID:26127,Genbank:NM_015633.2,HGNC:HGNC:23098,MIM:608858 FGFR1 oncogene partner 2 GO:0005737 cytoplasm FGFR2 218.209799687593 191.201230999961 245.218368375225 1.28251458995719 0.358975238104577 0.106281734232736 1 0.73089 0.666744 0.986524 0.883418 GeneID:2263,Genbank:NM_001144918.1,HGNC:HGNC:3689,MIM:176943 fibroblast growth factor receptor 2 hsa01521,hsa04010,hsa04014,hsa04015,hsa04144,hsa04151,hsa04550,hsa04810,hsa05200,hsa05215,hsa05226,hsa05230 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Pathways in cancer|Prostate cancer|Gastric cancer|Central carbon metabolism in cancer FGFR3 482.917945817528 401.735760739468 564.100130895588 1.40415712521399 0.48970438228321 0.00537178401123829 0.285941071095182 3.82816 3.60889 5.5022 5.50652 GeneID:2261,Genbank:XM_006713868.1,HGNC:HGNC:3690,MIM:134934 fibroblast growth factor receptor 3 hsa01521,hsa04010,hsa04014,hsa04015,hsa04144,hsa04151,hsa04550,hsa04810,hsa05200,hsa05206,hsa05219,hsa05230 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Pathways in cancer|MicroRNAs in cancer|Bladder cancer|Central carbon metabolism in cancer FGFR4 49.3118442260237 46.7674885940503 51.8561998579971 1.10880873480545 0.149010527676931 0.760282432682678 1 0.485595 0.561563 0.742504 0.754049 GeneID:2264,Genbank:NM_213647.2,HGNC:HGNC:3691,MIM:134935 fibroblast growth factor receptor 4 hsa04010,hsa04014,hsa04015,hsa04144,hsa04151,hsa04550,hsa04810,hsa05200 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Signaling pathways regulating pluripotency of stem cells|Regulation of actin cytoskeleton|Pathways in cancer FGFRL1 7207.06924385434 6221.73285595559 8192.40563175309 1.31674017856796 0.39697069861536 0.00279522490747557 0.195734784066614 54.6034 56.932 74.6262 75.5674 GeneID:53834,Genbank:XM_024454093.1,HGNC:HGNC:3693,MIM:605830 fibroblast growth factor receptor like 1 GO:0001501,GO:0003179,GO:0005007,GO:0005794,GO:0005886,GO:0008201,GO:0008285,GO:0008543,GO:0016021,GO:0017134,GO:0030133,GO:0044291,GO:0051260,GO:0060412,GO:0060539,GO:0098742 skeletal system development|heart valve morphogenesis|fibroblast growth factor-activated receptor activity|Golgi apparatus|plasma membrane|heparin binding|negative regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|integral component of membrane|fibroblast growth factor binding|transport vesicle|cell-cell contact zone|protein homooligomerization|ventricular septum morphogenesis|diaphragm development|cell-cell adhesion via plasma-membrane adhesion molecules FGGY 191.41462593779 179.295438528929 203.53381334665 1.13518679011909 0.182929706332313 0.428525526253627 1 0.288063 0.290387 0.313634 0.341318 GeneID:55277,Genbank:XM_011541731.1,HGNC:HGNC:25610,MIM:611370 FGGY carbohydrate kinase domain containing GO:0005623,GO:0019150,GO:0019321,GO:0046835,GO:0070050 cell|D-ribulokinase activity|pentose metabolic process|carbohydrate phosphorylation|neuron cellular homeostasis FGR 2.9330096283103 0.538097676642304 5.32792157997829 9.90140231272543 3.30763286522698 0.180516510046861 1 0.0130041 0 0.0242874 0.0793381 GeneID:2268,Genbank:XM_011541010.1,HGNC:HGNC:3697,MIM:164940 FGR proto-oncogene, Src family tyrosine kinase GO:0001784,GO:0002768,GO:0004713,GO:0004715,GO:0005524,GO:0005576,GO:0005743,GO:0005758,GO:0005829,GO:0005886,GO:0006468,GO:0007169,GO:0007229,GO:0008360,GO:0009615,GO:0014068,GO:0015629,GO:0016235,GO:0016477,GO:0018108,GO:0019901,GO:0030154,GO:0030335,GO:0031234,GO:0032587,GO:0034774,GO:0034987,GO:0034988,GO:0038083,GO:0038096,GO:0042127,GO:0043306,GO:0043312,GO:0043552,GO:0045087,GO:0045088,GO:0045859,GO:0046777,GO:0050715,GO:0050764,GO:0050830,GO:0070062 phosphotyrosine residue binding|immune response-regulating cell surface receptor signaling pathway|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|ATP binding|extracellular region|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|integrin-mediated signaling pathway|regulation of cell shape|response to virus|positive regulation of phosphatidylinositol 3-kinase signaling|actin cytoskeleton|aggresome|cell migration|peptidyl-tyrosine phosphorylation|protein kinase binding|cell differentiation|positive regulation of cell migration|extrinsic component of cytoplasmic side of plasma membrane|ruffle membrane|secretory granule lumen|immunoglobulin receptor binding|Fc-gamma receptor I complex binding|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of cell proliferation|positive regulation of mast cell degranulation|neutrophil degranulation|positive regulation of phosphatidylinositol 3-kinase activity|innate immune response|regulation of innate immune response|regulation of protein kinase activity|protein autophosphorylation|positive regulation of cytokine secretion|regulation of phagocytosis|defense response to Gram-positive bacterium|extracellular exosome hsa04062 Chemokine signaling pathway FH 3027.26996415807 3123.97574764179 2930.56418067434 0.938088006248624 -0.0922048200969911 0.491259157308775 1 50.5696 54.0085 51.5542 47.8077 GeneID:2271,Genbank:NM_000143.3,HGNC:HGNC:3700,MIM:136850 fumarate hydratase hsa00020,hsa00620,hsa04934,hsa05200,hsa05211 Citrate cycle (TCA cycle)|Pyruvate metabolism|Cushing syndrome|Pathways in cancer|Renal cell carcinoma FHAD1 4.26392026176237 4.65077399104097 3.87706653248377 0.833638989972931 -0.262505339673619 0.950442598222974 1 0.0165497 0.00380817 0.00782319 0.0109364 GeneID:114827,Genbank:XM_011540598.3,HGNC:HGNC:29408 forkhead associated phosphopeptide binding domain 1 FHDC1 200.95510207862 185.282156556896 216.628047600344 1.16917922171217 0.225496095358916 0.332049535174364 1 0.943325 1.00952 1.19274 1.14874 GeneID:85462,Genbank:XM_011532389.1,HGNC:HGNC:29363 FH2 domain containing 1 FHIT 21.7499957535174 16.8447241101821 26.6552673968526 1.58241044629163 0.662123855200674 0.290468010050079 1 0.0538294 0.0624172 0.0628963 0.0694642 GeneID:2272,Genbank:NM_001354589.1,HGNC:HGNC:3701,MIM:601153 fragile histidine triad hsa00230,hsa05222,hsa05223 Purine metabolism|Small cell lung cancer|Non-small cell lung cancer FHL1 2856.02795691846 2910.84576506759 2801.21014876934 0.962335477333096 -0.0553881789445807 0.682879171103265 1 28.2107 29.4655 29.9276 27.4519 GeneID:2273,Genbank:NM_001159702.2,HGNC:HGNC:3702,MIM:300163 four and a half LIM domains 1 GO:0003254,GO:0005634,GO:0005737,GO:0005886,GO:0005925,GO:0007275,GO:0010972,GO:0030154,GO:0030308,GO:0043268,GO:0044325,GO:0046872,GO:1901016,GO:2000134 regulation of membrane depolarization|nucleus|cytoplasm|plasma membrane|focal adhesion|multicellular organism development|negative regulation of G2/M transition of mitotic cell cycle|cell differentiation|negative regulation of cell growth|positive regulation of potassium ion transport|ion channel binding|metal ion binding|regulation of potassium ion transmembrane transporter activity|negative regulation of G1/S transition of mitotic cell cycle hsa04630 Jak-STAT signaling pathway FHL2 2002.15925591522 1802.67937808929 2201.63913374115 1.22131487190736 0.288435195064406 0.039584142294862 0.756156754175857 21.7188 21.2447 27.0811 25.3609 GeneID:2274,Genbank:NM_001318897.1,HGNC:HGNC:3703,MIM:602633 four and a half LIM domains 2 hsa04380 Osteoclast differentiation FHL3 412.102864638575 408.424272578347 415.781456698802 1.01801358198916 0.0257568094860048 0.916963855985324 1 9.89563 9.90877 9.68498 10.6991 GeneID:2275,Genbank:XM_017000675.1,HGNC:HGNC:3704,MIM:602790 four and a half LIM domains 3 GO:0001725,GO:0003779,GO:0005634,GO:0005925,GO:0007517,GO:0030018,GO:0030036,GO:0046872 stress fiber|actin binding|nucleus|focal adhesion|muscle organ development|Z disc|actin cytoskeleton organization|metal ion binding FHOD1 959.804016831638 1037.67457433731 881.933459325971 0.849913336162451 -0.234612354652239 0.218735116991286 1 7.55792 8.49304 6.26891 7.7443 GeneID:29109,Genbank:NM_013241.2,HGNC:HGNC:17905,MIM:606881 formin homology 2 domain containing 1 GO:0003779,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0007097,GO:0014704,GO:0016020,GO:0019904,GO:0032059,GO:0042802,GO:0043621,GO:0045944,GO:0051492,GO:0051496,GO:0051660 actin binding|nucleus|cytoplasm|cytosol|cytoskeleton|nuclear migration|intercalated disc|membrane|protein domain specific binding|bleb|identical protein binding|protein self-association|positive regulation of transcription from RNA polymerase II promoter|regulation of stress fiber assembly|positive regulation of stress fiber assembly|establishment of centrosome localization FHOD3 413.944506298728 428.564209332429 399.324803265028 0.931773569909285 -0.101948686421667 0.58424806401906 1 1.47017 1.44173 1.35889 1.3986 GeneID:80206,Genbank:NM_001281740.2,HGNC:HGNC:26178,MIM:609691 formin homology 2 domain containing 3 GO:0003779,GO:0005865,GO:0030018,GO:0030837,GO:0045214,GO:0051639,GO:0055003 actin binding|striated muscle thin filament|Z disc|negative regulation of actin filament polymerization|sarcomere organization|actin filament network formation|cardiac myofibril assembly FIBCD1 961.77309404059 919.915393045193 1003.63079503599 1.09100337120533 0.125655559602587 0.431909522860695 1 10.932 11.6836 12.0581 12.496 GeneID:84929,Genbank:NM_001145106.1,HGNC:HGNC:25922,MIM:613357 fibrinogen C domain containing 1 GO:0008061,GO:0016020,GO:0016021,GO:0046872 chitin binding|membrane|integral component of membrane|metal ion binding FIBIN 3.07406605103192 4.20872886376855 1.93940323829528 0.460804984372102 -1.11777177287705 0.609962064255547 1 0.0943181 0.0294829 0.045027 0.0139947 GeneID:387758,Genbank:NM_203371.1,HGNC:HGNC:33747,MIM:617085 fin bud initiation factor homolog (zebrafish) GO:0005576,GO:0005783,GO:0005794,GO:0010042,GO:0042803,GO:0071548,GO:1904627 extracellular region|endoplasmic reticulum|Golgi apparatus|response to manganese ion|protein homodimerization activity|response to dexamethasone|response to phorbol 13-acetate 12-myristate FIBP 1251.94147789927 1217.72964160694 1286.15331419159 1.0561895434313 0.0788687635126286 0.619079832151577 1 18.0608 21.1686 20.6369 20.7097 GeneID:9158,Genbank:NM_004214.4,HGNC:HGNC:3705,MIM:608296 FGF1 intracellular binding protein GO:0005634,GO:0012505,GO:0016020,GO:0017134 nucleus|endomembrane system|membrane|fibroblast growth factor binding FICD 128.282268256667 100.520438329343 156.044098183991 1.55236189552549 0.634464926092803 0.0186277423890598 0.557658897968661 2.25779 2.14967 3.32805 3.23282 GeneID:11153,Genbank:NM_007076.2,HGNC:HGNC:18416 FIC domain containing GO:0005524,GO:0016021,GO:0018117,GO:0034260,GO:0042802,GO:0070733 ATP binding|integral component of membrane|protein adenylylation|negative regulation of GTPase activity|identical protein binding|protein adenylyltransferase activity FIG4 578.740477590487 592.388068406824 565.09288677415 0.953923478394693 -0.0680545537805725 0.723744097068314 1 4.2757 3.69738 4.02548 3.56026 GeneID:9896,Genbank:NM_014845.5,HGNC:HGNC:16873,MIM:609390 FIG4 phosphoinositide 5-phosphatase GO:0000139,GO:0004438,GO:0005783,GO:0005811,GO:0006661,GO:0007033,GO:0007626,GO:0010008,GO:0010976,GO:0031642,GO:0031901,GO:0031902,GO:0032288,GO:0043231,GO:0043473,GO:0043812,GO:0043813,GO:0048666,GO:0055037 Golgi membrane|phosphatidylinositol-3-phosphatase activity|endoplasmic reticulum|lipid droplet|phosphatidylinositol biosynthetic process|vacuole organization|locomotory behavior|endosome membrane|positive regulation of neuron projection development|negative regulation of myelination|early endosome membrane|late endosome membrane|myelin assembly|intracellular membrane-bounded organelle|pigmentation|phosphatidylinositol-4-phosphate phosphatase activity|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|neuron development|recycling endosome hsa00562 Inositol phosphate metabolism FIGN 189.373375967331 191.153204725276 187.593547209385 0.981377986725326 -0.0271191841887726 0.942476699388717 1 0.381605 0.433066 0.516635 0.299775 GeneID:55137,Genbank:XM_011511389.2,HGNC:HGNC:13285,MIM:605295 fidgetin, microtubule severing factor GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005874,GO:0007049,GO:0008022,GO:0010569,GO:0016363,GO:0051301 ATP binding|nucleus|cytoplasm|microtubule organizing center|microtubule|cell cycle|protein C-terminus binding|regulation of double-strand break repair via homologous recombination|nuclear matrix|cell division FIGNL1 465.060236260232 480.337256149676 449.783216370787 0.936390443614959 -0.0948178838672303 0.645013727369754 1 1.81227 1.6317 1.85426 1.36642 GeneID:63979,Genbank:NM_001287495.2,HGNC:HGNC:13286,MIM:615383 fidgetin like 1 GO:0000228,GO:0000287,GO:0001649,GO:0005524,GO:0005634,GO:0005737,GO:0007140,GO:0010569,GO:0016787,GO:0033687,GO:0043066,GO:0046034,GO:0048471,GO:0051726,GO:0070062,GO:0071479,GO:2001243 nuclear chromosome|magnesium ion binding|osteoblast differentiation|ATP binding|nucleus|cytoplasm|male meiotic nuclear division|regulation of double-strand break repair via homologous recombination|hydrolase activity|osteoblast proliferation|negative regulation of apoptotic process|ATP metabolic process|perinuclear region of cytoplasm|regulation of cell cycle|extracellular exosome|cellular response to ionizing radiation|negative regulation of intrinsic apoptotic signaling pathway FIGNL2 3.70474598348939 4.01662376502878 3.39286820195 0.844706499894368 -0.243477942487412 0.95336540388694 1 0.0188394 0.0325714 0.034764 0.0244518 GeneID:401720,Genbank:XM_005268870.3,HGNC:HGNC:13287 fidgetin like 2 GO:0005524,GO:0005634,GO:0010569 ATP binding|nucleus|regulation of double-strand break repair via homologous recombination FILIP1 100.766836356864 100.712543428082 100.821129285646 1.00107817610267 0.00155464137846113 1 1 0.360614 0.358236 0.447669 0.279927 GeneID:27145,Genbank:NM_001300866.2,HGNC:HGNC:21015,MIM:607307 filamin A interacting protein 1 GO:0005730,GO:0005737,GO:0005886,GO:0015629 nucleolus|cytoplasm|plasma membrane|actin cytoskeleton FILIP1L 126.439344125316 133.642362907741 119.236325342891 0.8922045581101 -0.164553576291633 0.705746225269346 1 0.923472 0.616876 0.818893 0.558693 GeneID:11259,Genbank:NM_182909.3,HGNC:HGNC:24589,MIM:612993 filamin A interacting protein 1 like GO:0005634,GO:0005737,GO:0016020 nucleus|cytoplasm|membrane FIP1L1 796.605891915317 811.504769008993 781.70701482164 0.963280863741883 -0.0539715889788955 0.736721666243295 1 4.47384 4.54017 4.54303 4.09922 GeneID:81608,Genbank:XM_017008668.1,HGNC:HGNC:19124,MIM:607686 factor interacting with PAPOLA and CPSF1 GO:0003723,GO:0005634,GO:0006397 RNA binding|nucleus|mRNA processing hsa03015 mRNA surveillance pathway FIS1 2143.38504886742 2099.89093639206 2186.87916134277 1.04142511567776 0.0585591052216559 0.812062334142107 1 98.4005 110.241 101.469 122.125 GeneID:51024,Genbank:NM_016068.2,HGNC:HGNC:21689,MIM:609003 fission, mitochondrial 1 GO:0000266,GO:0000422,GO:0001836,GO:0005102,GO:0005739,GO:0005777,GO:0005779,GO:0005783,GO:0006626,GO:0007204,GO:0008053,GO:0010821,GO:0014850,GO:0016020,GO:0016559,GO:0031307,GO:0031667,GO:0032403,GO:0032471,GO:0035584,GO:0043234,GO:0043280,GO:0043525,GO:0043653,GO:0051260,GO:0051561,GO:0070584,GO:0071333,GO:0090141,GO:0090314,GO:0097237,GO:1901653,GO:1902617,GO:1904579,GO:1905395,GO:1990910,GO:2001244 mitochondrial fission|autophagy of mitochondrion|release of cytochrome c from mitochondria|receptor binding|mitochondrion|peroxisome|integral component of peroxisomal membrane|endoplasmic reticulum|protein targeting to mitochondrion|positive regulation of cytosolic calcium ion concentration|mitochondrial fusion|regulation of mitochondrion organization|response to muscle activity|membrane|peroxisome fission|integral component of mitochondrial outer membrane|response to nutrient levels|protein complex binding|negative regulation of endoplasmic reticulum calcium ion concentration|calcium-mediated signaling using intracellular calcium source|protein complex|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of neuron apoptotic process|mitochondrial fragmentation involved in apoptotic process|protein homooligomerization|positive regulation of mitochondrial calcium ion concentration|mitochondrion morphogenesis|cellular response to glucose stimulus|positive regulation of mitochondrial fission|positive regulation of protein targeting to membrane|cellular response to toxic substance|cellular response to peptide|response to fluoride|cellular response to thapsigargin|response to flavonoid|response to hypobaric hypoxia|positive regulation of intrinsic apoptotic signaling pathway hsa04137 Mitophagy - animal FITM1 1.99493416203551 1.56626675524197 2.42360156882906 1.54737471169439 0.629822601598113 0.890477131901486 1 0 0 0 0.0796003 GeneID:161247,Genbank:NM_203402.2,HGNC:HGNC:33714,MIM:612028 fat storage inducing transmembrane protein 1 GO:0005789,GO:0008654,GO:0010890,GO:0019915,GO:0030176,GO:0034389 endoplasmic reticulum membrane|phospholipid biosynthetic process|positive regulation of sequestering of triglyceride|lipid storage|integral component of endoplasmic reticulum membrane|lipid particle organization FITM2 437.815733416198 448.224900340516 427.40656649188 0.953553821233891 -0.0686137243243031 0.693382776786328 1 4.16722 4.66255 3.9165 4.5071 GeneID:128486,Genbank:NM_001080472.3,HGNC:HGNC:16135,MIM:612029 fat storage inducing transmembrane protein 2 GO:0005739,GO:0005789,GO:0007010,GO:0008654,GO:0010866,GO:0010890,GO:0019915,GO:0022604,GO:0030176,GO:0030730,GO:0034389,GO:0035356 mitochondrion|endoplasmic reticulum membrane|cytoskeleton organization|phospholipid biosynthetic process|regulation of triglyceride biosynthetic process|positive regulation of sequestering of triglyceride|lipid storage|regulation of cell morphogenesis|integral component of endoplasmic reticulum membrane|sequestering of triglyceride|lipid particle organization|cellular triglyceride homeostasis FIZ1 388.965230111056 412.536948892746 365.393511329367 0.885723114766054 -0.175072325435508 0.334011784352997 1 3.87089 4.34049 3.64903 3.88544 GeneID:84922,Genbank:NM_032836.2,HGNC:HGNC:25917,MIM:609133 FLT3 interacting zinc finger 1 GO:0001934,GO:0003676,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0030971,GO:0046872 positive regulation of protein phosphorylation|nucleic acid binding|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|receptor tyrosine kinase binding|metal ion binding FJX1 1365.00467260303 1312.3790317679 1417.63031343816 1.08019884432965 0.111296909909882 0.468755379028209 1 31.1925 33.6341 39.2894 31.9673 GeneID:24147,Genbank:NM_014344.3,HGNC:HGNC:17166,MIM:612206 four jointed box 1 GO:0005615,GO:0007267,GO:0010842 extracellular space|cell-cell signaling|retina layer formation FKBP10 1586.5207801349 1472.08040587279 1700.96115439701 1.15548114601017 0.208493719537656 0.149427384887534 1 15.0611 15.3245 17.3228 18.3723 GeneID:60681,Genbank:NM_021939.3,HGNC:HGNC:18169,MIM:607063 FK506 binding protein 10 FKBP11 92.3417560191378 84.3578907198576 100.325621318418 1.18928556015687 0.250095163156144 0.41629920462491 1 1.01983 0.747023 1.62766 0.892609 GeneID:51303,Genbank:NM_016594.2,HGNC:HGNC:18624,MIM:610571 FK506 binding protein 11 GO:0003755,GO:0005528,GO:0005737,GO:0016020,GO:0016021,GO:0061077 peptidyl-prolyl cis-trans isomerase activity|FK506 binding|cytoplasm|membrane|integral component of membrane|chaperone-mediated protein folding FKBP14 694.353361309038 672.364742474389 716.341980143687 1.06540681700152 0.091404417120041 0.559514079887907 1 5.87339 5.38134 6.79165 5.33366 GeneID:55033,Genbank:NM_017946.3,HGNC:HGNC:18625,MIM:614505 FK506 binding protein 14 GO:0003755,GO:0005509,GO:0005528,GO:0005737,GO:0005788,GO:0036498,GO:0061077 peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|FK506 binding|cytoplasm|endoplasmic reticulum lumen|IRE1-mediated unfolded protein response|chaperone-mediated protein folding FKBP15 945.145173487135 939.439779882624 950.850567091645 1.01214637431092 0.017417944401811 0.911946573508073 1 5.40568 5.45981 5.78022 5.22478 GeneID:23307,Genbank:XM_017014552.1,HGNC:HGNC:23397,MIM:617398 FK506 binding protein 15 GO:0003779,GO:0005769,GO:0005884,GO:0006897,GO:0010923,GO:0016020,GO:0030424,GO:0030426 actin binding|early endosome|actin filament|endocytosis|negative regulation of phosphatase activity|membrane|axon|growth cone FKBP1A 4884.80693678056 4950.60199784294 4819.01187571817 0.973419369567153 -0.0388666125449879 0.7621066872684 1 100.295 106.565 101.766 101.64 GeneID:2280,Genbank:NM_001199786.1,HGNC:HGNC:3711,MIM:186945 FK506 binding protein 1A GO:0000413,GO:0001933,GO:0003007,GO:0003755,GO:0004871,GO:0005160,GO:0005527,GO:0005528,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006936,GO:0007179,GO:0007183,GO:0010039,GO:0014802,GO:0016020,GO:0016529,GO:0019221,GO:0019899,GO:0022417,GO:0030018,GO:0030544,GO:0031000,GO:0031312,GO:0031398,GO:0032092,GO:0032515,GO:0032880,GO:0032925,GO:0034713,GO:0042026,GO:0042098,GO:0042110,GO:0042803,GO:0043123,GO:0043679,GO:0044325,GO:0046332,GO:0048185,GO:0050776,GO:0051209,GO:0055010,GO:0060314,GO:0060347,GO:0061077,GO:0070062,GO:0070588,GO:0097435,GO:0098562,GO:1902991,GO:1990000,GO:1990425 protein peptidyl-prolyl isomerization|negative regulation of protein phosphorylation|heart morphogenesis|peptidyl-prolyl cis-trans isomerase activity|signal transducer activity|transforming growth factor beta receptor binding|macrolide binding|FK506 binding|cytoplasm|cytosol|protein folding|'de novo' protein folding|muscle contraction|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|response to iron ion|terminal cisterna|membrane|sarcoplasmic reticulum|cytokine-mediated signaling pathway|enzyme binding|protein maturation by protein folding|Z disc|Hsp70 protein binding|response to caffeine|extrinsic component of organelle membrane|positive regulation of protein ubiquitination|positive regulation of protein binding|negative regulation of phosphoprotein phosphatase activity|regulation of protein localization|regulation of activin receptor signaling pathway|type I transforming growth factor beta receptor binding|protein refolding|T cell proliferation|T cell activation|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|axon terminus|ion channel binding|SMAD binding|activin binding|regulation of immune response|release of sequestered calcium ion into cytosol|ventricular cardiac muscle tissue morphogenesis|regulation of ryanodine-sensitive calcium-release channel activity|heart trabecula formation|chaperone-mediated protein folding|extracellular exosome|calcium ion transmembrane transport|supramolecular fiber organization|cytoplasmic side of membrane|regulation of amyloid precursor protein catabolic process|amyloid fibril formation|ryanodine receptor complex FKBP1B 133.769005379088 153.6774554582 113.860555299975 0.740906042206988 -0.432637495725607 0.282841310924115 1 0.669232 0.524728 0.415306 0.595329 GeneID:2281,Genbank:XM_017003594.1,HGNC:HGNC:3712,MIM:600620 FK506 binding protein 1B GO:0000413,GO:0002027,GO:0003755,GO:0005102,GO:0005528,GO:0005737,GO:0006939,GO:0007204,GO:0009749,GO:0010033,GO:0010459,GO:0010880,GO:0010881,GO:0014808,GO:0016020,GO:0016529,GO:0019227,GO:0019855,GO:0030018,GO:0030073,GO:0030551,GO:0032515,GO:0033017,GO:0033197,GO:0034704,GO:0042098,GO:0042542,GO:0043231,GO:0044325,GO:0048680,GO:0051209,GO:0051280,GO:0051284,GO:0051480,GO:0051775,GO:0060314,GO:0060315,GO:0061077,GO:0061179 protein peptidyl-prolyl isomerization|regulation of heart rate|peptidyl-prolyl cis-trans isomerase activity|receptor binding|FK506 binding|cytoplasm|smooth muscle contraction|positive regulation of cytosolic calcium ion concentration|response to glucose|response to organic substance|negative regulation of heart rate|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|membrane|sarcoplasmic reticulum|neuronal action potential propagation|calcium channel inhibitor activity|Z disc|insulin secretion|cyclic nucleotide binding|negative regulation of phosphoprotein phosphatase activity|sarcoplasmic reticulum membrane|response to vitamin E|calcium channel complex|T cell proliferation|response to hydrogen peroxide|intracellular membrane-bounded organelle|ion channel binding|positive regulation of axon regeneration|release of sequestered calcium ion into cytosol|negative regulation of release of sequestered calcium ion into cytosol|positive regulation of sequestering of calcium ion|regulation of cytosolic calcium ion concentration|response to redox state|regulation of ryanodine-sensitive calcium-release channel activity|negative regulation of ryanodine-sensitive calcium-release channel activity|chaperone-mediated protein folding|negative regulation of insulin secretion involved in cellular response to glucose stimulus FKBP2 1288.00889446303 1319.58500697235 1256.43278195371 0.952142359389535 -0.070750800943665 0.796585121114017 1 47.5008 48.0175 40.0259 53.4954 GeneID:2286,Genbank:NM_004470.3,HGNC:HGNC:3718,MIM:186946 FK506 binding protein 2 GO:0003755,GO:0005528,GO:0005783,GO:0005789,GO:0061077,GO:0070062 peptidyl-prolyl cis-trans isomerase activity|FK506 binding|endoplasmic reticulum|endoplasmic reticulum membrane|chaperone-mediated protein folding|extracellular exosome FKBP3 1070.31327138398 1042.00674771406 1098.61979505389 1.05433078764992 0.0763275717488139 0.610760872493604 1 6.20498 6.39362 6.51935 6.7131 GeneID:2287,Genbank:XM_011536565.3,HGNC:HGNC:3719,MIM:186947 FK506 binding protein 3 GO:0003723,GO:0003755,GO:0004872,GO:0005528,GO:0005634,GO:0005737,GO:0061077 RNA binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity|FK506 binding|nucleus|cytoplasm|chaperone-mediated protein folding FKBP4 2868.17370343773 3102.998729907 2633.34867696847 0.848646392145767 -0.236764547664311 0.0819276951767664 0.959822780610495 21.8186 22.7173 18.6489 19.7295 GeneID:2288,Genbank:NM_002014.3,HGNC:HGNC:3720,MIM:600611 FK506 binding protein 4 hsa04915 Estrogen signaling pathway FKBP5 1336.31625403892 1225.82849872019 1446.80400935766 1.18026625328761 0.239112350237806 0.258477989180213 1 3.98662 4.17163 5.70598 3.95088 GeneID:2289,Genbank:NM_001145775.2,HGNC:HGNC:3721,MIM:602623 FK506 binding protein 5 GO:0003755,GO:0005528,GO:0005654,GO:0005737,GO:0005829,GO:0006457,GO:0016020,GO:0031072,GO:0061077,GO:0070062 peptidyl-prolyl cis-trans isomerase activity|FK506 binding|nucleoplasm|cytoplasm|cytosol|protein folding|membrane|heat shock protein binding|chaperone-mediated protein folding|extracellular exosome hsa04915 Estrogen signaling pathway FKBP6 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:8468,Genbank:NM_001135211.2,HGNC:HGNC:3722,MIM:604839 FK506 binding protein 6 GO:0000795,GO:0003755,GO:0005528,GO:0005737,GO:0005829,GO:0006457,GO:0007283,GO:0030154,GO:0031047,GO:0034587,GO:0042802,GO:0043046,GO:0045070,GO:0051321,GO:0051879,GO:0061077 synaptonemal complex|peptidyl-prolyl cis-trans isomerase activity|FK506 binding|cytoplasm|cytosol|protein folding|spermatogenesis|cell differentiation|gene silencing by RNA|piRNA metabolic process|identical protein binding|DNA methylation involved in gamete generation|positive regulation of viral genome replication|meiotic cell cycle|Hsp90 protein binding|chaperone-mediated protein folding FKBP7 102.914974183573 101.644659957312 104.185288409834 1.02499519850417 0.0356171515741855 0.917794519731622 1 0.787725 0.810126 0.798358 0.887906 GeneID:51661,Genbank:XM_005246638.5,HGNC:HGNC:3723,MIM:607062 FK506 binding protein 7 GO:0003755,GO:0005509,GO:0005788 peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|endoplasmic reticulum lumen FKBP8 6732.2509637373 6316.66161211041 7147.8403153642 1.13158512427834 0.178345116425342 0.251523665445342 1 91.1681 95.7406 104.591 113.224 GeneID:23770,Genbank:NM_001308373.1,HGNC:HGNC:3724,MIM:604840 FK506 binding protein 8 FKBP9 3313.92003419078 3171.05980284842 3456.78026553314 1.09010251475802 0.124463814432067 0.363284866507203 1 18.0334 19.3071 20.1444 20.6973 GeneID:11328,Genbank:NM_001284341.1,HGNC:HGNC:3725,MIM:616257 FK506 binding protein 9 GO:0003755,GO:0005509,GO:0005528,GO:0005737,GO:0005783,GO:0006457,GO:0061077 peptidyl-prolyl cis-trans isomerase activity|calcium ion binding|FK506 binding|cytoplasm|endoplasmic reticulum|protein folding|chaperone-mediated protein folding FKBPL 301.370458562455 295.998041777973 306.742875346936 1.03630035355782 0.0514422035914577 0.823483051494467 1 8.39498 9.5091 8.87245 10.2188 GeneID:63943,Genbank:NM_022110.3,HGNC:HGNC:13949,MIM:617076 FK506 binding protein like GO:0005576,GO:0005829,GO:0009314,GO:0050821,GO:1905553 extracellular region|cytosol|response to radiation|protein stabilization|regulation of blood vessel branching FKRP 850.867538240234 729.050345968027 972.684730512441 1.33418046626248 0.415953824073203 0.00875271105840342 0.364112780029582 8.82638 9.70383 13.516 11.8631 GeneID:79147,Genbank:XM_005259248.2,HGNC:HGNC:17997,MIM:606596 fukutin related protein GO:0000139,GO:0005615,GO:0005634,GO:0005791,GO:0005794,GO:0005829,GO:0016010,GO:0016021,GO:0016485,GO:0016740,GO:0035269,GO:0042383 Golgi membrane|extracellular space|nucleus|rough endoplasmic reticulum|Golgi apparatus|cytosol|dystrophin-associated glycoprotein complex|integral component of membrane|protein processing|transferase activity|protein O-linked mannosylation|sarcolemma hsa00515 Mannose type O-glycan biosynthesis FKTN 288.74137952825 297.813231560893 279.669527495608 0.939076904104662 -0.090684785115555 0.740808748360569 1 0.849898 0.769523 0.914556 0.670654 GeneID:2218,Genbank:XM_017014469.1,HGNC:HGNC:3622,MIM:607440 fukutin GO:0000139,GO:0005615,GO:0005634,GO:0005783,GO:0005794,GO:0005801,GO:0007399,GO:0007517,GO:0008285,GO:0016021,GO:0016740,GO:0035269,GO:0046329,GO:0060049 Golgi membrane|extracellular space|nucleus|endoplasmic reticulum|Golgi apparatus|cis-Golgi network|nervous system development|muscle organ development|negative regulation of cell proliferation|integral component of membrane|transferase activity|protein O-linked mannosylation|negative regulation of JNK cascade|regulation of protein glycosylation hsa00515 Mannose type O-glycan biosynthesis FLAD1 1068.76180886209 1105.84150848321 1031.68210924097 0.932938491932756 -0.100146126681415 0.576131978769089 1 7.88161 8.87799 6.95368 8.67172 GeneID:80308,Genbank:NM_025207.4,HGNC:HGNC:24671,MIM:610595 flavin adenine dinucleotide synthetase 1 GO:0003919,GO:0005524,GO:0005737,GO:0005759,GO:0005829,GO:0005886,GO:0006747,GO:0006771,GO:0055114 FMN adenylyltransferase activity|ATP binding|cytoplasm|mitochondrial matrix|cytosol|plasma membrane|FAD biosynthetic process|riboflavin metabolic process|oxidation-reduction process hsa00740 Riboflavin metabolism FLCN 986.50765148351 919.415512988128 1053.59978997889 1.14594519571968 0.196538049545038 0.208186165362833 1 5.45887 5.95057 6.99339 6.11923 GeneID:201163,Genbank:XM_011523719.3,HGNC:HGNC:27310,MIM:607273 folliculin hsa04150,hsa05211 mTOR signaling pathway|Renal cell carcinoma FLG 27.094920235838 28.9906479546384 25.1991925170377 0.86921798217366 -0.202210073929587 0.719294221225604 1 0.0404036 0.0546267 0.0379905 0.0462576 GeneID:2312,Genbank:NM_002016.1,HGNC:HGNC:3748,MIM:135940 filaggrin GO:0001533,GO:0005198,GO:0005509,GO:0005634,GO:0005829,GO:0005882,GO:0007275,GO:0018149,GO:0030216,GO:0030280,GO:0036457,GO:0043231,GO:0046914,GO:0061436,GO:0070268 cornified envelope|structural molecule activity|calcium ion binding|nucleus|cytosol|intermediate filament|multicellular organism development|peptide cross-linking|keratinocyte differentiation|structural constituent of epidermis|keratohyalin granule|intracellular membrane-bounded organelle|transition metal ion binding|establishment of skin barrier|cornification FLG2 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0 0 0 GeneID:388698,Genbank:XM_011509531.2,HGNC:HGNC:33276,MIM:616284 filaggrin family member 2 GO:0005198,GO:0005509,GO:0005576,GO:0005634,GO:0005737,GO:0043312,GO:0046914,GO:0061436,GO:0070062,GO:1904724 structural molecule activity|calcium ion binding|extracellular region|nucleus|cytoplasm|neutrophil degranulation|transition metal ion binding|establishment of skin barrier|extracellular exosome|tertiary granule lumen FLI1 304.126386462537 335.404650687555 272.848122237519 0.813489382685065 -0.297804578304327 0.131689142172691 1 2.18111 2.36645 1.83554 1.83117 GeneID:2313,Genbank:XM_017017405.1,HGNC:HGNC:3749,MIM:193067 Fli-1 proto-oncogene, ETS transcription factor hsa05202 Transcriptional misregulation in cancer FLII 6319.56822323281 5979.86790610697 6659.26854035866 1.11361465586185 0.155250103188721 0.243405933593876 1 41.0727 41.2707 48.0604 45.5255 GeneID:2314,Genbank:NM_001256265.1,HGNC:HGNC:3750,MIM:600362 FLII, actin remodeling protein GO:0003779,GO:0005654,GO:0005815,GO:0005829,GO:0005903,GO:0005925,GO:0006351,GO:0006355,GO:0007275,GO:0030036,GO:0051014,GO:0051015 actin binding|nucleoplasm|microtubule organizing center|cytosol|brush border|focal adhesion|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|actin cytoskeleton organization|actin filament severing|actin filament binding FLJ20712 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.017128 0.0158494 0 0 GeneID:55025,Genbank:XM_017012879.1 uncharacterized FLJ20712 FLJ45513 6.43998457992765 3.67063118712625 9.20933797272905 2.50892489690284 1.32706928521997 0.267404750704333 1 0.0793442 0.0360351 0.0558345 0.0174429 GeneID:729220,Genbank:NM_001242791.1 uncharacterized LOC729220 GO:0003085,GO:0005102,GO:0005615,GO:0005623,GO:0006954,GO:0007204,GO:0007217,GO:0007267,GO:0008217,GO:0031835,GO:0031837,GO:0048018,GO:0050965,GO:0051930,GO:1902093,GO:1904057,GO:1904058 negative regulation of systemic arterial blood pressure|receptor binding|extracellular space|cell|inflammatory response|positive regulation of cytosolic calcium ion concentration|tachykinin receptor signaling pathway|cell-cell signaling|regulation of blood pressure|substance P receptor binding|substance K receptor binding|receptor ligand activity|detection of temperature stimulus involved in sensory perception of pain|regulation of sensory perception of pain|positive regulation of flagellated sperm motility|negative regulation of sensory perception of pain|positive regulation of sensory perception of pain FLNA 88616.989170356 86537.8192572529 90696.159083459 1.04805228352062 0.0677106894845717 0.614015444187692 1 322.689 334.031 349.951 353.675 GeneID:2316,Genbank:NM_001456.3,HGNC:HGNC:3754,MIM:300017 filamin A GO:0001664,GO:0002576,GO:0003723,GO:0004871,GO:0005576,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0005911,GO:0005925,GO:0007195,GO:0008134,GO:0015459,GO:0015629,GO:0016020,GO:0016479,GO:0017048,GO:0017160,GO:0019900,GO:0021943,GO:0021987,GO:0030018,GO:0030168,GO:0030334,GO:0030863,GO:0031012,GO:0031267,GO:0031523,GO:0031532,GO:0031852,GO:0034329,GO:0034394,GO:0034988,GO:0042177,GO:0042789,GO:0042803,GO:0042993,GO:0043025,GO:0043066,GO:0043113,GO:0043123,GO:0043198,GO:0043433,GO:0044319,GO:0044325,GO:0045184,GO:0045296,GO:0046332,GO:0048365,GO:0048471,GO:0050821,GO:0051015,GO:0051020,GO:0051220,GO:0051764,GO:0060271,GO:0070062,GO:0070527,GO:0071526,GO:0072659,GO:0090307,GO:0097440,GO:1900026,GO:1901381,GO:1905000,GO:1905031,GO:2000179,GO:2001046,GO:2001224 G-protein coupled receptor binding|platelet degranulation|RNA binding|signal transducer activity|extracellular region|nucleus|nucleolus|cytoplasm|cytosol|actin filament|plasma membrane|cell-cell junction|focal adhesion|adenylate cyclase-inhibiting dopamine receptor signaling pathway|transcription factor binding|potassium channel regulator activity|actin cytoskeleton|membrane|negative regulation of transcription from RNA polymerase I promoter|Rho GTPase binding|Ral GTPase binding|kinase binding|formation of radial glial scaffolds|cerebral cortex development|Z disc|platelet activation|regulation of cell migration|cortical cytoskeleton|extracellular matrix|small GTPase binding|Myb complex|actin cytoskeleton reorganization|mu-type opioid receptor binding|cell junction assembly|protein localization to cell surface|Fc-gamma receptor I complex binding|negative regulation of protein catabolic process|mRNA transcription from RNA polymerase II promoter|protein homodimerization activity|positive regulation of transcription factor import into nucleus|neuronal cell body|negative regulation of apoptotic process|receptor clustering|positive regulation of I-kappaB kinase/NF-kappaB signaling|dendritic shaft|negative regulation of DNA binding transcription factor activity|wound healing, spreading of cells|ion channel binding|establishment of protein localization|cadherin binding|SMAD binding|Rac GTPase binding|perinuclear region of cytoplasm|protein stabilization|actin filament binding|GTPase binding|cytoplasmic sequestering of protein|actin crosslink formation|cilium assembly|extracellular exosome|platelet aggregation|semaphorin-plexin signaling pathway|protein localization to plasma membrane|mitotic spindle assembly|apical dendrite|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of potassium ion transmembrane transport|regulation of membrane repolarization during atrial cardiac muscle cell action potential|regulation of membrane repolarization during cardiac muscle cell action potential|positive regulation of neural precursor cell proliferation|positive regulation of integrin-mediated signaling pathway|positive regulation of neuron migration hsa04010,hsa04510,hsa05132,hsa05205 MAPK signaling pathway|Focal adhesion|Salmonella infection|Proteoglycans in cancer FLNB 15240.6708281069 15847.1551818567 14634.186474357 0.923458267835451 -0.114881329291157 0.3644259082045 1 49.2697 51.7014 48.2885 47.0839 GeneID:2317,Genbank:NM_001164317.1,HGNC:HGNC:3755,MIM:603381 filamin B GO:0001725,GO:0003334,GO:0003382,GO:0003723,GO:0003779,GO:0005737,GO:0005829,GO:0005886,GO:0005903,GO:0005925,GO:0005938,GO:0007016,GO:0007165,GO:0007519,GO:0015629,GO:0016021,GO:0030018,GO:0030036,GO:0031012,GO:0042802,GO:0045296,GO:0045335,GO:0070062,GO:0071346 stress fiber|keratinocyte development|epithelial cell morphogenesis|RNA binding|actin binding|cytoplasm|cytosol|plasma membrane|brush border|focal adhesion|cell cortex|cytoskeletal anchoring at plasma membrane|signal transduction|skeletal muscle tissue development|actin cytoskeleton|integral component of membrane|Z disc|actin cytoskeleton organization|extracellular matrix|identical protein binding|cadherin binding|phagocytic vesicle|extracellular exosome|cellular response to interferon-gamma hsa04010,hsa04510,hsa05132,hsa05205 MAPK signaling pathway|Focal adhesion|Salmonella infection|Proteoglycans in cancer FLNC 4.83059918909064 6.75513842292525 2.90605995525603 0.43019991202454 -1.21692086515608 0.417915888511934 1 0.0340942 0.0182453 0.00394963 0.0147221 GeneID:2318,Genbank:NM_001458.4,HGNC:HGNC:3756,MIM:102565 filamin C GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0008092,GO:0016528,GO:0030018,GO:0030506,GO:0034329,GO:0042383,GO:0042802,GO:0043034,GO:0048747,GO:0051015 cytoplasm|cytosol|cytoskeleton|plasma membrane|focal adhesion|cytoskeletal protein binding|sarcoplasm|Z disc|ankyrin binding|cell junction assembly|sarcolemma|identical protein binding|costamere|muscle fiber development|actin filament binding hsa04010,hsa04510,hsa05132,hsa05205 MAPK signaling pathway|Focal adhesion|Salmonella infection|Proteoglycans in cancer FLOT1 14242.4587467275 14696.1036598805 13788.8138335746 0.938263239882915 -0.0919353516843524 0.574753981971752 1 221.592 227.55 198.941 232.275 GeneID:10211,Genbank:NM_001318875.1,HGNC:HGNC:3757,MIM:606998 flotillin 1 GO:0001931,GO:0001934,GO:0002020,GO:0002090,GO:0005768,GO:0005769,GO:0005913,GO:0007409,GO:0008180,GO:0016323,GO:0016600,GO:0022617,GO:0030027,GO:0030864,GO:0032092,GO:0032226,GO:0032728,GO:0033227,GO:0034116,GO:0034141,GO:0034451,GO:0034976,GO:0035023,GO:0042383,GO:0042470,GO:0044291,GO:0044854,GO:0045121,GO:0045807,GO:0046982,GO:0048643,GO:0050821,GO:0051260,GO:0060355,GO:0070528,GO:0071360,GO:0072659,GO:1901741,GO:1901890,GO:1903044,GO:2000049 uropod|positive regulation of protein phosphorylation|protease binding|regulation of receptor internalization|endosome|early endosome|cell-cell adherens junction|axonogenesis|COP9 signalosome|basolateral plasma membrane|flotillin complex|extracellular matrix disassembly|lamellipodium|cortical actin cytoskeleton|positive regulation of protein binding|positive regulation of synaptic transmission, dopaminergic|positive regulation of interferon-beta production|dsRNA transport|positive regulation of heterotypic cell-cell adhesion|positive regulation of toll-like receptor 3 signaling pathway|centriolar satellite|response to endoplasmic reticulum stress|regulation of Rho protein signal transduction|sarcolemma|melanosome|cell-cell contact zone|plasma membrane raft assembly|membrane raft|positive regulation of endocytosis|protein heterodimerization activity|positive regulation of skeletal muscle tissue development|protein stabilization|protein homooligomerization|positive regulation of cell adhesion molecule production|protein kinase C signaling|cellular response to exogenous dsRNA|protein localization to plasma membrane|positive regulation of myoblast fusion|positive regulation of cell junction assembly|protein localization to membrane raft|positive regulation of cell-cell adhesion mediated by cadherin hsa04910 Insulin signaling pathway FLOT2 4142.15844489007 3742.49352183323 4541.82336794691 1.2135821589137 0.279271781538121 0.0390745380780848 0.753859521009372 40.8584 43.7682 52.6122 52.5495 GeneID:2319,Genbank:NM_001330170.1,HGNC:HGNC:3758,MIM:131560 flotillin 2 GO:0001765,GO:0001931,GO:0002020,GO:0002080,GO:0005768,GO:0005886,GO:0005901,GO:0005913,GO:0005925,GO:0007155,GO:0008544,GO:0010629,GO:0016020,GO:0016323,GO:0016600,GO:0030027,GO:0030139,GO:0031410,GO:0031982,GO:0035255,GO:0044291,GO:0044860,GO:0045661,GO:0046982,GO:0048471,GO:0050821,GO:0070062,GO:0072659,GO:1902992,GO:1903905 membrane raft assembly|uropod|protease binding|acrosomal membrane|endosome|plasma membrane|caveola|cell-cell adherens junction|focal adhesion|cell adhesion|epidermis development|negative regulation of gene expression|membrane|basolateral plasma membrane|flotillin complex|lamellipodium|endocytic vesicle|cytoplasmic vesicle|vesicle|ionotropic glutamate receptor binding|cell-cell contact zone|protein localization to plasma membrane raft|regulation of myoblast differentiation|protein heterodimerization activity|perinuclear region of cytoplasm|protein stabilization|extracellular exosome|protein localization to plasma membrane|negative regulation of amyloid precursor protein catabolic process|positive regulation of establishment of T cell polarity hsa04910 Insulin signaling pathway FLRT1 13.9989934563581 12.9721791692082 15.0258077435081 1.15831022278621 0.212021692823468 0.807337802495543 1 0.0445129 0.0301449 0.0414437 0.032806 GeneID:23769,Genbank:XM_005273861.2,HGNC:HGNC:3760,MIM:604806 fibronectin leucine rich transmembrane protein 1 GO:0004860,GO:0005057,GO:0005104,GO:0005578,GO:0005615,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0006469,GO:0007155,GO:0008543,GO:0016358,GO:0019221,GO:0030659,GO:0030674,GO:0031410,GO:0032809,GO:0044306,GO:0046426,GO:0048471,GO:0051965,GO:1990138 protein kinase inhibitor activity|signal transducer activity, downstream of receptor|fibroblast growth factor receptor binding|proteinaceous extracellular matrix|extracellular space|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|negative regulation of protein kinase activity|cell adhesion|fibroblast growth factor receptor signaling pathway|dendrite development|cytokine-mediated signaling pathway|cytoplasmic vesicle membrane|protein binding, bridging|cytoplasmic vesicle|neuronal cell body membrane|neuron projection terminus|negative regulation of JAK-STAT cascade|perinuclear region of cytoplasm|positive regulation of synapse assembly|neuron projection extension FLRT2 171.839324659464 166.765304486994 176.913344831934 1.0608522280828 0.085223709353878 0.73257684650344 1 0.336298 0.345359 0.426121 0.297087 GeneID:23768,Genbank:XM_024449522.1,HGNC:HGNC:3761,MIM:604807 fibronectin leucine rich transmembrane protein 2 GO:0003007,GO:0004860,GO:0005057,GO:0005104,GO:0005578,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0006469,GO:0007411,GO:0008543,GO:0019221,GO:0030674,GO:0031090,GO:0043005,GO:0045202,GO:0045499,GO:0046426,GO:0051965,GO:0061343,GO:0070062,GO:0071711,GO:2001222 heart morphogenesis|protein kinase inhibitor activity|signal transducer activity, downstream of receptor|fibroblast growth factor receptor binding|proteinaceous extracellular matrix|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|negative regulation of protein kinase activity|axon guidance|fibroblast growth factor receptor signaling pathway|cytokine-mediated signaling pathway|protein binding, bridging|organelle membrane|neuron projection|synapse|chemorepellent activity|negative regulation of JAK-STAT cascade|positive regulation of synapse assembly|cell adhesion involved in heart morphogenesis|extracellular exosome|basement membrane organization|regulation of neuron migration FLRT3 110.685773041749 85.6742174465669 135.697328636932 1.58387590434151 0.663459305616733 0.0188119233112351 0.562111499538698 0.599456 0.468094 0.921812 0.850385 GeneID:23767,Genbank:XM_011529205.2,HGNC:HGNC:3762,MIM:604808 fibronectin leucine rich transmembrane protein 3 GO:0003345,GO:0004860,GO:0005057,GO:0005104,GO:0005578,GO:0005615,GO:0005737,GO:0005789,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0005925,GO:0006469,GO:0007411,GO:0007416,GO:0007507,GO:0008543,GO:0019221,GO:0030054,GO:0030674,GO:0031175,GO:0042803,GO:0043679,GO:0044295,GO:0045499,GO:0046426,GO:0048598,GO:0048678,GO:0051965,GO:0060322,GO:0097060,GO:0098742,GO:1990138 proepicardium cell migration involved in pericardium morphogenesis|protein kinase inhibitor activity|signal transducer activity, downstream of receptor|fibroblast growth factor receptor binding|proteinaceous extracellular matrix|extracellular space|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|integral component of plasma membrane|cell-cell junction|focal adhesion|negative regulation of protein kinase activity|axon guidance|synapse assembly|heart development|fibroblast growth factor receptor signaling pathway|cytokine-mediated signaling pathway|cell junction|protein binding, bridging|neuron projection development|protein homodimerization activity|axon terminus|axonal growth cone|chemorepellent activity|negative regulation of JAK-STAT cascade|embryonic morphogenesis|response to axon injury|positive regulation of synapse assembly|head development|synaptic membrane|cell-cell adhesion via plasma-membrane adhesion molecules|neuron projection extension FLT1 1.72588532371436 1.02816907859967 2.42360156882906 2.35720137793866 1.23707501465219 0.731188896846623 1 0.00329836 0.00315944 0.00953691 0.00591121 GeneID:2321,Genbank:XM_017020485.1,HGNC:HGNC:3763,MIM:165070 fms related tyrosine kinase 1 GO:0001525,GO:0002548,GO:0004714,GO:0005021,GO:0005524,GO:0005615,GO:0005768,GO:0005886,GO:0005887,GO:0005925,GO:0007169,GO:0008284,GO:0010863,GO:0014068,GO:0015629,GO:0016477,GO:0018108,GO:0019838,GO:0030154,GO:0030335,GO:0030949,GO:0035924,GO:0036323,GO:0036326,GO:0036327,GO:0036332,GO:0043235,GO:0043406,GO:0043410,GO:0043552,GO:0045766,GO:0046777,GO:0048010,GO:0048514,GO:0048598 angiogenesis|monocyte chemotaxis|transmembrane receptor protein tyrosine kinase activity|vascular endothelial growth factor-activated receptor activity|ATP binding|extracellular space|endosome|plasma membrane|integral component of plasma membrane|focal adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of cell proliferation|positive regulation of phospholipase C activity|positive regulation of phosphatidylinositol 3-kinase signaling|actin cytoskeleton|cell migration|peptidyl-tyrosine phosphorylation|growth factor binding|cell differentiation|positive regulation of cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|cellular response to vascular endothelial growth factor stimulus|vascular endothelial growth factor receptor-1 signaling pathway|VEGF-A-activated receptor activity|VEGF-B-activated receptor activity|placental growth factor-activated receptor activity|receptor complex|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of angiogenesis|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|blood vessel morphogenesis|embryonic morphogenesis hsa04010,hsa04014,hsa04015,hsa04066,hsa04151,hsa04510,hsa05202,hsa05323 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Transcriptional misregulation in cancer|Rheumatoid arthritis FLT3LG 76.0320117239845 60.4600618835326 91.6039615644364 1.515115246506 0.599427535770218 0.069337308312663 0.918407228165493 0.428686 0.234167 0.532081 0.462198 GeneID:2323,Genbank:XM_017026533.1,HGNC:HGNC:3766,MIM:600007 fms related tyrosine kinase 3 ligand GO:0001934,GO:0005102,GO:0005125,GO:0005576,GO:0005615,GO:0007165,GO:0008284,GO:0016020,GO:0016021,GO:0019221,GO:0030098,GO:0030885,GO:0030971,GO:0031233,GO:0032825,GO:0035162,GO:0042803,GO:0045663,GO:0045787,GO:0045944,GO:0048873,GO:0071864,GO:0071866,GO:0090290,GO:1901741 positive regulation of protein phosphorylation|receptor binding|cytokine activity|extracellular region|extracellular space|signal transduction|positive regulation of cell proliferation|membrane|integral component of membrane|cytokine-mediated signaling pathway|lymphocyte differentiation|regulation of myeloid dendritic cell activation|receptor tyrosine kinase binding|intrinsic component of external side of plasma membrane|positive regulation of natural killer cell differentiation|embryonic hemopoiesis|protein homodimerization activity|positive regulation of myoblast differentiation|positive regulation of cell cycle|positive regulation of transcription from RNA polymerase II promoter|homeostasis of number of cells within a tissue|positive regulation of cell proliferation in bone marrow|negative regulation of apoptotic process in bone marrow|positive regulation of osteoclast proliferation|positive regulation of myoblast fusion hsa04010,hsa04014,hsa04151,hsa04640,hsa05200 MAPK signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Hematopoietic cell lineage|Pathways in cancer FLT4 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:2324,Genbank:NM_182925.4,HGNC:HGNC:3767,MIM:136352 fms related tyrosine kinase 4 hsa04010,hsa04014,hsa04015,hsa04151,hsa04510,hsa05200,hsa05224 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Pathways in cancer|Breast cancer FLVCR1 221.949536437367 231.626200333035 212.2728725417 0.916445860772624 -0.125878439110618 0.589368263589018 1 1.52729 1.35104 1.38336 1.33239 GeneID:28982,Genbank:NM_014053.3,HGNC:HGNC:24682,MIM:609144 feline leukemia virus subgroup C cellular receptor 1 GO:0001568,GO:0001701,GO:0005215,GO:0005739,GO:0005886,GO:0005887,GO:0006810,GO:0006839,GO:0006879,GO:0007275,GO:0015232,GO:0015886,GO:0030218,GO:0031966,GO:0035264,GO:0042733,GO:0043249,GO:0046620,GO:0048536,GO:0048704,GO:0060323,GO:0097037 blood vessel development|in utero embryonic development|transporter activity|mitochondrion|plasma membrane|integral component of plasma membrane|transport|mitochondrial transport|cellular iron ion homeostasis|multicellular organism development|heme transporter activity|heme transport|erythrocyte differentiation|mitochondrial membrane|multicellular organism growth|embryonic digit morphogenesis|erythrocyte maturation|regulation of organ growth|spleen development|embryonic skeletal system morphogenesis|head morphogenesis|heme export FLVCR2 3.53381625819652 4.16070258908361 2.90692992730943 0.698663234170189 -0.517330871714798 0.844322141609216 1 0.059792 0.0327135 0.0225685 0.0421093 GeneID:55640,Genbank:NM_017791.2,HGNC:HGNC:20105,MIM:610865 feline leukemia virus subgroup C cellular receptor family member 2 GO:0005886,GO:0015232,GO:0016021,GO:0020037 plasma membrane|heme transporter activity|integral component of membrane|heme binding FLYWCH1 1174.6968462189 1111.71153965073 1237.68215278707 1.11331231946725 0.154858371241792 0.303391460648571 1 5.64295 5.51125 6.2949 6.737 GeneID:84256,Genbank:XM_011522707.2,HGNC:HGNC:25404 FLYWCH-type zinc finger 1 GO:0003677,GO:0005654,GO:0005829,GO:0016604,GO:0046872 DNA binding|nucleoplasm|cytosol|nuclear body|metal ion binding FLYWCH2 377.724461736707 386.688643103699 368.760280369715 0.953636179769635 -0.0684891239949145 0.757161876188621 1 11.2292 12.4084 10.2531 12.6076 GeneID:114984,Genbank:XM_005255078.5,HGNC:HGNC:25178 FLYWCH family member 2 GO:0003723 RNA binding FMC1 7.92366237190003 5.18887166768327 10.6584530761168 2.05409841652059 1.03850530610827 0.33071786479372 1 7.88638 10.4878 10.0994 18.1165 GeneID:154791,Genbank:NM_197964.4,HGNC:HGNC:26946 formation of mitochondrial complex V assembly factor 1 homolog GO:0005739,GO:0050995,GO:0061469 mitochondrion|negative regulation of lipid catabolic process|regulation of type B pancreatic cell proliferation FMN1 60.9762904391944 47.785849017542 74.1667318608468 1.55206475108605 0.634188747036689 0.193243988236655 1 0.0628051 0.0625759 0.133384 0.0681821 GeneID:342184,Genbank:XM_011521506.3,HGNC:HGNC:3768,MIM:136535 formin 1 GO:0003779,GO:0005634,GO:0005737,GO:0005884,GO:0005886,GO:0005912,GO:0008017,GO:0010467,GO:0015630,GO:0017124,GO:0035136,GO:0035137,GO:0045010,GO:0048705,GO:0048813,GO:0051127,GO:0051894,GO:0072092 actin binding|nucleus|cytoplasm|actin filament|plasma membrane|adherens junction|microtubule binding|gene expression|microtubule cytoskeleton|SH3 domain binding|forelimb morphogenesis|hindlimb morphogenesis|actin nucleation|skeletal system morphogenesis|dendrite morphogenesis|positive regulation of actin nucleation|positive regulation of focal adhesion assembly|ureteric bud invasion FMN2 282.244431170761 275.616956649611 288.87190569191 1.0480919214965 0.0677652520581787 0.754524345723361 1 1.02197 1.08935 1.25624 0.917944 GeneID:56776,Genbank:NM_001305424.1,HGNC:HGNC:14074,MIM:606373 formin 2 GO:0003779,GO:0005730,GO:0005789,GO:0005819,GO:0005829,GO:0005886,GO:0005902,GO:0005938,GO:0006974,GO:0007275,GO:0015031,GO:0016192,GO:0030659,GO:0035556,GO:0040038,GO:0042177,GO:0043066,GO:0046907,GO:0048471,GO:0048477,GO:0051295,GO:0051758,GO:0070649,GO:0071456 actin binding|nucleolus|endoplasmic reticulum membrane|spindle|cytosol|plasma membrane|microvillus|cell cortex|cellular response to DNA damage stimulus|multicellular organism development|protein transport|vesicle-mediated transport|cytoplasmic vesicle membrane|intracellular signal transduction|polar body extrusion after meiotic divisions|negative regulation of protein catabolic process|negative regulation of apoptotic process|intracellular transport|perinuclear region of cytoplasm|oogenesis|establishment of meiotic spindle localization|homologous chromosome movement towards spindle pole involved in homologous chromosome segregation|formin-nucleated actin cable assembly|cellular response to hypoxia FMNL1 230.374251165674 230.579430945074 230.169071386275 0.998220311512103 -0.00256983518775531 0.986322352746185 1 1.19665 1.28292 1.04136 1.46242 GeneID:752,Genbank:XM_006722062.4,HGNC:HGNC:1212,MIM:604656 formin like 1 GO:0005522,GO:0005829,GO:0005886,GO:0005938,GO:0006929,GO:0008360,GO:0016020,GO:0030866,GO:0032059,GO:0032794,GO:0045335,GO:0048365,GO:0051014,GO:0051015,GO:0070062 profilin binding|cytosol|plasma membrane|cell cortex|substrate-dependent cell migration|regulation of cell shape|membrane|cortical actin cytoskeleton organization|bleb|GTPase activating protein binding|phagocytic vesicle|Rac GTPase binding|actin filament severing|actin filament binding|extracellular exosome FMNL2 647.785081293449 622.792112638396 672.778049948502 1.08026103140315 0.111379963507477 0.678950331836127 1 2.90767 2.92442 3.80175 2.49578 GeneID:114793,Genbank:XM_011510532.3,HGNC:HGNC:18267,MIM:616285 formin like 2 GO:0003779,GO:0005829,GO:0007010,GO:0017048,GO:0022604,GO:0030866,GO:0045296 actin binding|cytosol|cytoskeleton organization|Rho GTPase binding|regulation of cell morphogenesis|cortical actin cytoskeleton organization|cadherin binding FMNL3 498.878189958565 496.635090928963 501.121288988168 1.00903318782975 0.0129736265057022 0.953005691252121 1 1.17169 1.19481 1.2668 1.13738 GeneID:91010,Genbank:XM_005269218.2,HGNC:HGNC:23698,MIM:616288 formin like 3 GO:0001525,GO:0003779,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0007010,GO:0008360,GO:0016477,GO:0017048,GO:0030036,GO:0032794,GO:0043231 angiogenesis|actin binding|cytoplasm|Golgi apparatus|cytosol|plasma membrane|cytoskeleton organization|regulation of cell shape|cell migration|Rho GTPase binding|actin cytoskeleton organization|GTPase activating protein binding|intracellular membrane-bounded organelle FMO4 63.2520211025246 53.8107846650852 72.6932575399639 1.35090499037325 0.433926212977939 0.237695368520231 1 0.467386 0.544338 0.646911 0.683254 GeneID:2329,Genbank:XM_006711243.3,HGNC:HGNC:3772,MIM:136131 flavin containing monooxygenase 4 hsa00982 Drug metabolism - cytochrome P450 FMO5 84.2378737018722 98.2043514885027 70.2713959152417 0.715562954697264 -0.482849395113485 0.142039828147473 1 0.525517 0.392654 0.337431 0.336581 GeneID:2330,Genbank:XM_006711245.4,HGNC:HGNC:3773,MIM:603957 flavin containing monooxygenase 5 hsa00982 Drug metabolism - cytochrome P450 FMR1 842.561755248428 885.320203258359 799.803307238496 0.903405687902384 -0.146554097779268 0.672423836778173 1 7.71279 6.95751 8.3232 4.84113 GeneID:2332,Genbank:NM_002024.5,HGNC:HGNC:3775,MIM:309550 fragile X mental retardation 1 GO:0000381,GO:0000775,GO:0002092,GO:0002151,GO:0003682,GO:0003723,GO:0003729,GO:0003730,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005829,GO:0005844,GO:0005845,GO:0006397,GO:0006974,GO:0007215,GO:0007399,GO:0008017,GO:0008266,GO:0008380,GO:0010369,GO:0010494,GO:0014069,GO:0015030,GO:0016020,GO:0016032,GO:0019034,GO:0019897,GO:0030054,GO:0030371,GO:0030424,GO:0030425,GO:0030426,GO:0030529,GO:0031047,GO:0031369,GO:0032433,GO:0033129,GO:0033592,GO:0034046,GO:0034644,GO:0035064,GO:0035197,GO:0035198,GO:0035613,GO:0036464,GO:0042734,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043022,GO:0043197,GO:0043204,GO:0043488,GO:0043679,GO:0044325,GO:0044830,GO:0045202,GO:0045211,GO:0045727,GO:0045947,GO:0046928,GO:0046982,GO:0048027,GO:0048471,GO:0051028,GO:0051489,GO:0051491,GO:0060964,GO:0060998,GO:0060999,GO:0070840,GO:0071598,GO:0072711,GO:0097386,GO:0098586,GO:0098793,GO:0098794,GO:0098908,GO:1900453,GO:1901254,GO:1901386,GO:1901800,GO:1902373,GO:1902416,GO:1902737,GO:1990124,GO:1990812,GO:1990825,GO:1990904,GO:2000301,GO:2000637,GO:2000766,GO:2001022 regulation of alternative mRNA splicing, via spliceosome|chromosome, centromeric region|positive regulation of receptor internalization|G-quadruplex RNA binding|chromatin binding|RNA binding|mRNA binding|mRNA 3'-UTR binding|nucleus|nucleoplasm|chromosome|nucleolus|cytoplasm|cytosol|polysome|mRNA cap binding complex|mRNA processing|cellular response to DNA damage stimulus|glutamate receptor signaling pathway|nervous system development|microtubule binding|poly(U) RNA binding|RNA splicing|chromocenter|cytoplasmic stress granule|postsynaptic density|Cajal body|membrane|viral process|viral replication complex|extrinsic component of plasma membrane|cell junction|translation repressor activity|axon|dendrite|growth cone|intracellular ribonucleoprotein complex|gene silencing by RNA|translation initiation factor binding|filopodium tip|positive regulation of histone phosphorylation|RNA strand annealing activity|poly(G) binding|cellular response to UV|methylated histone binding|siRNA binding|miRNA binding|RNA stem-loop binding|cytoplasmic ribonucleoprotein granule|presynaptic membrane|identical protein binding|protein homodimerization activity|cell projection|neuron projection|ribosome binding|dendritic spine|perikaryon|regulation of mRNA stability|axon terminus|ion channel binding|modulation by host of viral RNA genome replication|synapse|postsynaptic membrane|positive regulation of translation|negative regulation of translational initiation|regulation of neurotransmitter secretion|protein heterodimerization activity|mRNA 5'-UTR binding|perinuclear region of cytoplasm|mRNA transport|regulation of filopodium assembly|positive regulation of filopodium assembly|regulation of gene silencing by miRNA|regulation of dendritic spine development|positive regulation of dendritic spine development|dynein complex binding|neuronal ribonucleoprotein granule|cellular response to hydroxyurea|glial cell projection|cellular response to virus|presynapse|postsynapse|regulation of neuronal action potential|negative regulation of long term synaptic depression|positive regulation of intracellular transport of viral material|negative regulation of voltage-gated calcium channel activity|positive regulation of proteasomal protein catabolic process|negative regulation of mRNA catabolic process|positive regulation of mRNA binding|dendritic filopodium|messenger ribonucleoprotein complex|growth cone filopodium|sequence-specific mRNA binding|ribonucleoprotein complex|negative regulation of synaptic vesicle exocytosis|positive regulation of gene silencing by miRNA|negative regulation of cytoplasmic translation|positive regulation of response to DNA damage stimulus hsa03013 RNA transport FN1 5406.81595926107 5072.6835438567 5740.94837466543 1.13173793023577 0.178539920606647 0.205281744744256 1 13.0764 13.3832 17.4437 13.6839 GeneID:2335,Genbank:NM_001306132.1,HGNC:HGNC:3778,MIM:135600 fibronectin 1 hsa04151,hsa04510,hsa04512,hsa04810,hsa04933,hsa05100,hsa05146,hsa05165,hsa05200,hsa05205,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|AGE-RAGE signaling pathway in diabetic complications|Bacterial invasion of epithelial cells|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer FN3K 279.997418705951 281.353734649045 278.641102762856 0.990358642690233 -0.0139770259243525 0.939463074422889 1 5.44365 5.75487 5.46284 6.38894 GeneID:64122,Genbank:NM_022158.3,HGNC:HGNC:24822,MIM:608425 fructosamine 3 kinase GO:0005829,GO:0016301,GO:0030387,GO:0030389,GO:0030393,GO:0030855,GO:0043687 cytosol|kinase activity|fructosamine-3-kinase activity|fructosamine metabolic process|fructoselysine metabolic process|epithelial cell differentiation|post-translational protein modification FN3KRP 1619.04228544199 1604.41828471064 1633.66628617335 1.01822966101884 0.0260629970171812 0.8870959587849 1 27.1035 31.4486 30.9076 29.5457 GeneID:79672,Genbank:NM_024619.3,HGNC:HGNC:25700,MIM:611683 fructosamine 3 kinase related protein GO:0005829,GO:0016301,GO:0043687 cytosol|kinase activity|post-translational protein modification FNBP1 489.234104724812 413.401421837075 565.066787612549 1.36687190165313 0.450878045058656 0.010497410630537 0.412074825143823 1.87262 2.07987 2.78947 2.78806 GeneID:23048,Genbank:NM_015033.2,HGNC:HGNC:17069,MIM:606191 formin binding protein 1 FNBP1L 395.737315661344 397.468179945052 394.006451377637 0.991290551691726 -0.012620115127087 1 1 2.65113 1.95985 2.3483 2.19873 GeneID:54874,Genbank:XM_011541625.2,HGNC:HGNC:20851,MIM:608848 formin binding protein 1 like GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0006900,GO:0006914,GO:0008289,GO:0010324,GO:0016050,GO:0030050,GO:0031410,GO:0045296,GO:0051020,GO:0051491,GO:0060271,GO:0061024,GO:0070062,GO:0072583,GO:0097320 cytoplasm|cytosol|cytoskeleton|plasma membrane|cell cortex|vesicle budding from membrane|autophagy|lipid binding|membrane invagination|vesicle organization|vesicle transport along actin filament|cytoplasmic vesicle|cadherin binding|GTPase binding|positive regulation of filopodium assembly|cilium assembly|membrane organization|extracellular exosome|clathrin-dependent endocytosis|plasma membrane tubulation FNBP4 782.738265693861 852.072800165267 713.403731222456 0.837256782617735 -0.256257936634577 0.116010612333386 1 4.34748 3.69159 3.82674 3.25751 GeneID:23360,Genbank:NM_015308.4,HGNC:HGNC:19752,MIM:615265 formin binding protein 4 GO:0016607 nuclear speck FNDC10 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0385779 0 0 0 GeneID:643988,Genbank:NM_001242659.1,HGNC:HGNC:42951 fibronectin type III domain containing 10 GO:0016021 integral component of membrane FNDC11 1.2383154714421 0.538097676642304 1.93853326624189 3.60256761994999 1.84902550994227 0.680597935457111 1 0.0260507 0 0.0480639 0.0223982 GeneID:79025,Genbank:NM_024059.3,HGNC:HGNC:28764 fibronectin type III domain containing 11 GO:0070062 extracellular exosome FNDC3A 633.736588455902 626.154968867197 641.318208044608 1.02421643192394 0.0345206101328752 0.925054413550009 1 2.65854 2.55378 3.3923 1.91875 GeneID:22862,Genbank:XM_017020440.2,HGNC:HGNC:20296,MIM:615794 fibronectin type III domain containing 3A GO:0000139,GO:0001669,GO:0003723,GO:0005794,GO:0005829,GO:0007286,GO:0009566,GO:0012506,GO:0016020,GO:0016021,GO:0060009,GO:0098609 Golgi membrane|acrosomal vesicle|RNA binding|Golgi apparatus|cytosol|spermatid development|fertilization|vesicle membrane|membrane|integral component of membrane|Sertoli cell development|cell-cell adhesion FNDC3B 1626.32044159162 1679.8165520229 1572.82433116034 0.936307199298809 -0.0949461439337978 0.661268441073969 1 5.8743 5.50603 6.27742 4.37321 GeneID:64778,Genbank:NM_022763.3,HGNC:HGNC:24670,MIM:611909 fibronectin type III domain containing 3B GO:0003723,GO:0016021 RNA binding|integral component of membrane FNDC4 629.891862700106 582.290708066168 677.493017334044 1.16349618489371 0.218466480151127 0.195591927005958 1 11.2268 11.899 13.235 14.0143 GeneID:64838,Genbank:XM_005264499.4,HGNC:HGNC:20239,MIM:611905 fibronectin type III domain containing 4 GO:0005615,GO:0005783,GO:0005886,GO:0016021,GO:0050728,GO:0071559 extracellular space|endoplasmic reticulum|plasma membrane|integral component of membrane|negative regulation of inflammatory response|response to transforming growth factor beta FNDC5 6.94593525204898 7.59120240278514 6.30066810131283 0.829996062152311 -0.268823603158896 0.856437652325657 1 0.0696189 0.126334 0.0921645 0.0734749 GeneID:252995,Genbank:NM_001171941.2,HGNC:HGNC:20240,MIM:611906 fibronectin type III domain containing 5 GO:0005179,GO:0005576,GO:0005778,GO:0005783,GO:0005886,GO:0014850,GO:0016021,GO:0090336 hormone activity|extracellular region|peroxisomal membrane|endoplasmic reticulum|plasma membrane|response to muscle activity|integral component of membrane|positive regulation of brown fat cell differentiation FNDC8 4.02095112444209 4.65077399104097 3.3911282578432 0.729153526784082 -0.455705481967161 0.84785657466759 1 0.0952071 0.0518993 0.0359098 0.0836068 GeneID:54752,Genbank:XM_024450811.1,HGNC:HGNC:25286 fibronectin type III domain containing 8 GO:0005634 nucleus FNDC9 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.0202678 0 0.0383367 0 GeneID:408263,Genbank:NM_001001343.3,HGNC:HGNC:33547 fibronectin type III domain containing 9 GO:0016021 integral component of membrane FNIP1 453.627438432902 478.819015669119 428.435861196685 0.894776203902372 -0.160401205688069 0.387433459247605 1 3.17535 2.91415 2.88093 2.60866 GeneID:96459,Genbank:NM_001346114.1,HGNC:HGNC:29418,MIM:610594 folliculin interacting protein 1 hsa04150 mTOR signaling pathway FNIP2 213.693712488465 196.188188913797 231.199236063134 1.17845644706329 0.23689844100905 0.29382724790901 1 0.58731 0.5925 0.822777 0.594677 GeneID:57600,Genbank:NM_020840.2,HGNC:HGNC:29280,MIM:612768 folliculin interacting protein 2 GO:0000122,GO:0001932,GO:0005737,GO:0006468,GO:0008630,GO:0031334,GO:0033138,GO:0042030,GO:0051087 negative regulation of transcription from RNA polymerase II promoter|regulation of protein phosphorylation|cytoplasm|protein phosphorylation|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of protein complex assembly|positive regulation of peptidyl-serine phosphorylation|ATPase inhibitor activity|chaperone binding hsa04150 mTOR signaling pathway FNTA 874.648715549811 928.341642426984 820.955788672638 0.884325070807332 -0.177351304643022 0.253354952863356 1 18.8554 19.8706 17.9336 17.0197 GeneID:2339,Genbank:NM_002027.2,HGNC:HGNC:3782,MIM:134635 farnesyltransferase, CAAX box, alpha GO:0004660,GO:0004661,GO:0004662,GO:0004663,GO:0005737,GO:0005829,GO:0005875,GO:0005886,GO:0005953,GO:0005965,GO:0007179,GO:0008017,GO:0018343,GO:0018344,GO:0022400,GO:0030548,GO:0030971,GO:0043014,GO:0045213,GO:0071340,GO:0090044,GO:0090045,GO:0097194 protein farnesyltransferase activity|protein geranylgeranyltransferase activity|CAAX-protein geranylgeranyltransferase activity|Rab geranylgeranyltransferase activity|cytoplasm|cytosol|microtubule associated complex|plasma membrane|CAAX-protein geranylgeranyltransferase complex|protein farnesyltransferase complex|transforming growth factor beta receptor signaling pathway|microtubule binding|protein farnesylation|protein geranylgeranylation|regulation of rhodopsin mediated signaling pathway|acetylcholine receptor regulator activity|receptor tyrosine kinase binding|alpha-tubulin binding|neurotransmitter receptor metabolic process|skeletal muscle acetylcholine-gated channel clustering|positive regulation of tubulin deacetylation|positive regulation of deacetylase activity|execution phase of apoptosis hsa00900 Terpenoid backbone biosynthesis FNTB 52.5615798469348 44.0671915557308 61.0559681381388 1.38551983874268 0.470427368380331 0.239999257743529 1 13.5084 14.0991 18.2294 20.5471 GeneID:2342,Genbank:NM_002028.3,HGNC:HGNC:3785,MIM:134636 farnesyltransferase, CAAX box, beta GO:0004660,GO:0005829,GO:0005875,GO:0005965,GO:0008270,GO:0018343,GO:0022400,GO:0042127 protein farnesyltransferase activity|cytosol|microtubule associated complex|protein farnesyltransferase complex|zinc ion binding|protein farnesylation|regulation of rhodopsin mediated signaling pathway|regulation of cell proliferation hsa00900 Terpenoid backbone biosynthesis FOCAD 1504.55061419935 1447.62486204961 1561.47636634909 1.07864710484337 0.109222943263018 0.451011861643744 1 6.96211 7.25089 7.96225 7.45147 GeneID:54914,Genbank:NM_017794.4,HGNC:HGNC:23377,MIM:614606 focadhesin GO:0005925,GO:0016021 focal adhesion|integral component of membrane FOLR1 2.96463578118315 1.56626675524197 4.36300480712434 2.78560774690663 1.47799212031024 0.470908044696347 1 0.069744 0.0309875 0.130265 0.0914616 GeneID:2348,Genbank:NM_016724.2,HGNC:HGNC:3791,MIM:136430 folate receptor 1 GO:0000139,GO:0001947,GO:0003147,GO:0003253,GO:0004872,GO:0005542,GO:0005634,GO:0005768,GO:0005789,GO:0005886,GO:0005887,GO:0006888,GO:0006898,GO:0008144,GO:0008517,GO:0009986,GO:0012507,GO:0015884,GO:0016020,GO:0016323,GO:0016324,GO:0017015,GO:0030133,GO:0030136,GO:0031103,GO:0031362,GO:0031526,GO:0033116,GO:0046655,GO:0048208,GO:0051870,GO:0060828,GO:0061626,GO:0061713,GO:0061714,GO:0070062,GO:0071231 Golgi membrane|heart looping|neural crest cell migration involved in heart formation|cardiac neural crest cell migration involved in outflow tract morphogenesis|receptor activity|folic acid binding|nucleus|endosome|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|ER to Golgi vesicle-mediated transport|receptor-mediated endocytosis|drug binding|folic acid transmembrane transporter activity|cell surface|ER to Golgi transport vesicle membrane|folic acid transport|membrane|basolateral plasma membrane|apical plasma membrane|regulation of transforming growth factor beta receptor signaling pathway|transport vesicle|clathrin-coated vesicle|axon regeneration|anchored component of external side of plasma membrane|brush border membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|folic acid metabolic process|COPII vesicle coating|methotrexate binding|regulation of canonical Wnt signaling pathway|pharyngeal arch artery morphogenesis|anterior neural tube closure|folic acid receptor activity|extracellular exosome|cellular response to folic acid hsa01523,hsa04144 Antifolate resistance|Endocytosis FOPNL 870.422841045558 857.443968276582 883.401713814533 1.03027340152631 0.0430272332204811 0.820877081937241 1 16.5087 13.8414 14.7457 17.1639 GeneID:123811,Genbank:NM_001304500.1,HGNC:HGNC:26435,MIM:617149 FGFR1OP N-terminal like GO:0005634,GO:0005813,GO:0005814,GO:0031514,GO:0034451,GO:0034453,GO:0036064,GO:0060271 nucleus|centrosome|centriole|motile cilium|centriolar satellite|microtubule anchoring|ciliary basal body|cilium assembly FOS 39.4467513959577 28.4907678975731 50.4027348943424 1.76909008123421 0.823007511251133 0.0663556285648203 0.908334826576206 0.723651 0.496375 1.17146 1.01039 GeneID:2353,Genbank:NM_005252.3,HGNC:HGNC:3796,MIM:164810 Fos proto-oncogene, AP-1 transcription factor subunit hsa01522,hsa04010,hsa04024,hsa04210,hsa04380,hsa04620,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04713,hsa04725,hsa04728,hsa04915,hsa04917,hsa04921,hsa04926,hsa04928,hsa05031,hsa05132,hsa05133,hsa05140,hsa05142,hsa05161,hsa05166,hsa05167,hsa05168,hsa05170,hsa05200,hsa05210,hsa05224,hsa05231,hsa05323,hsa05418 Endocrine resistance|MAPK signaling pathway|cAMP signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Circadian entrainment|Cholinergic synapse|Dopaminergic synapse|Estrogen signaling pathway|Prolactin signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Amphetamine addiction|Salmonella infection|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Hepatitis B|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Breast cancer|Choline metabolism in cancer|Rheumatoid arthritis|Fluid shear stress and atherosclerosis FOSB 43.8233779890271 41.6070258908361 46.0397300872181 1.10653739606412 0.146052208666793 0.721123176513062 1 0.587731 0.316594 0.498377 0.48924 GeneID:2354,Genbank:NM_006732.2,HGNC:HGNC:3797,MIM:164772 FosB proto-oncogene, AP-1 transcription factor subunit hsa04380,hsa04657,hsa05030,hsa05031,hsa05034 Osteoclast differentiation|IL-17 signaling pathway|Cocaine addiction|Amphetamine addiction|Alcoholism FOSL1 2379.70049394862 2605.45215675987 2153.94883113737 0.826708264647624 -0.274549785321563 0.118516540439589 1 51.6564 52.0228 50.6231 37.6062 GeneID:8061,Genbank:NM_001300857.1,HGNC:HGNC:13718,MIM:136515 FOS like 1, AP-1 transcription factor subunit hsa04310,hsa04380,hsa04657,hsa05166 Wnt signaling pathway|Osteoclast differentiation|IL-17 signaling pathway|Human T-cell leukemia virus 1 infection FOSL2 4714.25021455785 4875.76718616923 4552.73324294646 0.933747053358269 -0.0988963097160038 0.448662184460794 1 23.148 24.328 23.9572 21.3263 GeneID:2355,Genbank:XM_006711976.3,HGNC:HGNC:3798,MIM:601575 FOS like 2, AP-1 transcription factor subunit GO:0000977,GO:0001228,GO:0003334,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0006357,GO:0008219,GO:0045944,GO:0048146 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|keratinocyte development|chromatin binding|DNA binding transcription factor activity|nucleus|nucleoplasm|regulation of transcription from RNA polymerase II promoter|cell death|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation hsa04380 Osteoclast differentiation FOXA1 156.0800491939 159.981757099599 152.178341288202 0.951223089726789 -0.0721443597974488 0.752602810833246 1 1.56635 2.03753 1.86001 1.64413 GeneID:3169,Genbank:NM_004496.3,HGNC:HGNC:5021,MIM:602294 forkhead box A1 FOXA3 6.44074618550595 4.16070258908361 8.72078978192829 2.09598970251057 1.06763162900636 0.378149127689449 1 0.127987 0.065948 0.14267 0.2435 GeneID:3171,Genbank:NM_004497.2,HGNC:HGNC:5023,MIM:602295 forkhead box A3 hsa04950 Maturity onset diabetes of the young FOXB2 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0 0 0 0 GeneID:442425,Genbank:NM_001013735.1,HGNC:HGNC:23315 forkhead box B2 GO:0000981,GO:0005634,GO:0006351,GO:0009653,GO:0030154,GO:0043565 RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleus|transcription, DNA-templated|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding FOXC1 394.987032847025 399.795092441854 390.178973252196 0.975947380617093 -0.0351247296496385 0.863026188844823 1 5.80765 6.20891 7.06438 4.89442 GeneID:2296,Genbank:NM_001453.2,HGNC:HGNC:3800,MIM:601090 forkhead box C1 FOXC2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0357681 0 GeneID:2303,Genbank:NM_005251.2,HGNC:HGNC:3801,MIM:602402 forkhead box C2 FOXD2 27.3185527156344 29.4326930819108 25.2044123493581 0.856340678007771 -0.223743236702807 0.682211386280405 1 0.295103 0.445303 0.362358 0.254338 GeneID:2306,Genbank:NM_004474.3,HGNC:HGNC:3803,MIM:602211 forkhead box D2 GO:0000981,GO:0001228,GO:0003700,GO:0005634,GO:0009653,GO:0030154,GO:0043565,GO:0045944 RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter FOXD3 3.75483882183273 4.60274771635603 2.90692992730943 0.631564036625243 -0.662999073245288 0.741556269902215 1 0.126229 0.172758 0.07577 0.141167 GeneID:27022,Genbank:NM_012183.2,HGNC:HGNC:3804,MIM:611539 forkhead box D3 GO:0000122,GO:0000790,GO:0000977,GO:0001227,GO:0001701,GO:0003700,GO:0005654,GO:0006351,GO:0009653,GO:0030154,GO:0035019,GO:0045944 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|in utero embryonic development|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|anatomical structure morphogenesis|cell differentiation|somatic stem cell population maintenance|positive regulation of transcription from RNA polymerase II promoter FOXD4 27.8561929053964 27.1264148961788 28.5859709146139 1.05380571019139 0.0756089022869981 0.927993201401228 1 0.597516 0.679655 0.469464 0.77988 GeneID:2298,Genbank:NM_207305.4,HGNC:HGNC:3805,MIM:601092 forkhead box D4 GO:0000981,GO:0003700,GO:0005634,GO:0006351,GO:0008301,GO:0009653,GO:0030154,GO:0043565 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|DNA binding, bending|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding FOXD4L1 11.8293230612646 11.0599198360637 12.5987262864655 1.13913359890585 0.187936957911672 0.837142354422657 1 0.465953 0.0746987 0.26744 0.349913 GeneID:200350,Genbank:NM_012184.4,HGNC:HGNC:18521,MIM:611084 forkhead box D4 like 1 GO:0000981,GO:0005634,GO:0006351,GO:0009653,GO:0030154,GO:0043565 RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleus|transcription, DNA-templated|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding FOXD4L3 1.21930543346982 1.47021420587209 0.968396661067546 0.658677257504203 -0.60235635659317 0.974344551264944 1 0 0.0739361 0 0.024524 GeneID:286380,Genbank:NM_199135.4,HGNC:HGNC:18523,MIM:611086 forkhead box D4 like 3 GO:0000981,GO:0005634,GO:0009653,GO:0030154,GO:0043565 RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleus|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding FOXD4L4 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0 0 0 0 GeneID:349334,Genbank:NM_199244.3,HGNC:HGNC:23762,MIM:611085 forkhead box D4 like 4 GO:0000981,GO:0005634,GO:0006351,GO:0009653,GO:0030154,GO:0043565 RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleus|transcription, DNA-templated|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding FOXD4L5 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.0466769 0 0 GeneID:653427,Genbank:NM_001126334.1,HGNC:HGNC:18522 forkhead box D4 like 5 GO:0000981,GO:0005634,GO:0006351,GO:0009653,GO:0030154,GO:0043565 RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleus|transcription, DNA-templated|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding FOXD4L6 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0186084 0 0 GeneID:653404,Genbank:NM_001085476.1,HGNC:HGNC:31986 forkhead box D4 like 6 GO:0000981,GO:0005634,GO:0006351,GO:0009653,GO:0030154,GO:0043565 RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleus|transcription, DNA-templated|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding FOXE1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0158088 0 0 GeneID:2304,Genbank:NM_004473.3,HGNC:HGNC:3806,MIM:602617 forkhead box E1 FOXE3 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0.0384639 0.084783 0 GeneID:2301,Genbank:NM_012186.2,HGNC:HGNC:3808,MIM:601094 forkhead box E3 GO:0000981,GO:0001654,GO:0002088,GO:0002930,GO:0003677,GO:0003700,GO:0005634,GO:0005667,GO:0006366,GO:0009653,GO:0030154,GO:0042789,GO:0043066,GO:0043565,GO:0048468,GO:0061072,GO:0061073,GO:0061303,GO:0071157,GO:1902747,GO:2001111 RNA polymerase II transcription factor activity, sequence-specific DNA binding|eye development|lens development in camera-type eye|trabecular meshwork development|DNA binding|DNA binding transcription factor activity|nucleus|transcription factor complex|transcription from RNA polymerase II promoter|anatomical structure morphogenesis|cell differentiation|mRNA transcription from RNA polymerase II promoter|negative regulation of apoptotic process|sequence-specific DNA binding|cell development|iris morphogenesis|ciliary body morphogenesis|cornea development in camera-type eye|negative regulation of cell cycle arrest|negative regulation of lens fiber cell differentiation|positive regulation of lens epithelial cell proliferation FOXF1 116.267259206921 122.99607923448 109.538439179361 0.890584804500443 -0.167175098712743 0.555327249495746 1 2.8762 2.78687 2.94387 2.21737 GeneID:2294,Genbank:NM_001451.2,HGNC:HGNC:3809,MIM:601089 forkhead box F1 FOXF2 53.9197892738464 52.5905104877458 55.2490680599471 1.05055203966542 0.0711476284628447 0.893759129439695 1 1.27152 1.51904 1.55068 1.31194 GeneID:2295,Genbank:NM_001452.1,HGNC:HGNC:3810,MIM:603250 forkhead box F2 GO:0000977,GO:0001228,GO:0001837,GO:0003677,GO:0003700,GO:0003705,GO:0005634,GO:0005667,GO:0008134,GO:0009653,GO:0030154,GO:0030198,GO:0042249,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0048566,GO:0048596,GO:0048806,GO:0060021 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|epithelial to mesenchymal transition|DNA binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|transcription factor complex|transcription factor binding|anatomical structure morphogenesis|cell differentiation|extracellular matrix organization|establishment of planar polarity of embryonic epithelium|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|embryonic digestive tract development|embryonic camera-type eye morphogenesis|genitalia development|palate development FOXG1 1889.17342258891 1767.57755059284 2010.76929458497 1.13758476617366 0.185974050526304 0.186596972204554 1 28.6577 27.1814 33.2716 30.099 GeneID:2290,Genbank:NM_005249.4,HGNC:HGNC:3811,MIM:164874 forkhead box G1 hsa04068 FoxO signaling pathway FOXH1 15.529306699314 18.4590171401091 12.5995962585189 0.682571350515817 -0.550948233243088 0.464326935023034 1 0.307053 0.26046 0.194078 0.203004 GeneID:8928,Genbank:NM_003923.2,HGNC:HGNC:3814,MIM:603621 forkhead box H1 GO:0000122,GO:0000790,GO:0001104,GO:0001190,GO:0001205,GO:0001947,GO:0003139,GO:0003151,GO:0003215,GO:0003222,GO:0003700,GO:0003705,GO:0005634,GO:0005654,GO:0005667,GO:0007179,GO:0009653,GO:0019904,GO:0030154,GO:0032444,GO:0033147,GO:0035054,GO:0035326,GO:0035909,GO:0043425,GO:0043565,GO:0044212,GO:0045893,GO:0045944,GO:0046332,GO:0048318,GO:0050681,GO:0060766,GO:0070410,GO:0070412,GO:0071345,GO:1900164,GO:2000824 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II transcription cofactor activity|transcriptional activator activity, RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|heart looping|secondary heart field specification|outflow tract morphogenesis|cardiac right ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|nucleoplasm|transcription factor complex|transforming growth factor beta receptor signaling pathway|anatomical structure morphogenesis|protein domain specific binding|cell differentiation|activin responsive factor complex|negative regulation of intracellular estrogen receptor signaling pathway|embryonic heart tube anterior/posterior pattern specification|enhancer binding|aorta morphogenesis|bHLH transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|SMAD binding|axial mesoderm development|androgen receptor binding|negative regulation of androgen receptor signaling pathway|co-SMAD binding|R-SMAD binding|cellular response to cytokine stimulus|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|negative regulation of androgen receptor activity FOXI1 8.27562679304238 7.83133377620985 8.7199198098749 1.1134654784303 0.15505682990886 0.921247011721478 1 0.171526 0.060376 0.0636747 0.194108 GeneID:2299,Genbank:NM_012188.4,HGNC:HGNC:3815,MIM:601093 forkhead box I1 GO:0000978,GO:0001077,GO:0003700,GO:0005634,GO:0005730,GO:0008301,GO:0009653,GO:0009790,GO:0030154,GO:0042472,GO:0043231,GO:0043565,GO:0044212,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleolus|DNA binding, bending|anatomical structure morphogenesis|embryo development|cell differentiation|inner ear morphogenesis|intracellular membrane-bounded organelle|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter FOXJ1 1.69937063668679 0.490071401957362 2.90866987141623 5.93519609550547 2.56929569647876 0.446173868546987 1 0 0.0155358 0.0674418 0.015799 GeneID:2302,Genbank:NM_001454.3,HGNC:HGNC:3816,MIM:602291 forkhead box J1 GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001077,GO:0002508,GO:0002635,GO:0002897,GO:0002924,GO:0003677,GO:0003700,GO:0005634,GO:0006959,GO:0007283,GO:0007368,GO:0007389,GO:0007420,GO:0007507,GO:0030036,GO:0032088,GO:0033085,GO:0035089,GO:0035502,GO:0042130,GO:0044458,GO:0045409,GO:0045944,GO:0050869,GO:0050900,GO:0060271,GO:0060428,GO:0060429,GO:0060972,GO:0072016,GO:0090630,GO:1901248 negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|central tolerance induction|negative regulation of germinal center formation|positive regulation of central B cell tolerance induction|negative regulation of humoral immune response mediated by circulating immunoglobulin|DNA binding|DNA binding transcription factor activity|nucleus|humoral immune response|spermatogenesis|determination of left/right symmetry|pattern specification process|brain development|heart development|actin cytoskeleton organization|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|establishment of apical/basal cell polarity|metanephric part of ureteric bud development|negative regulation of T cell proliferation|motile cilium assembly|negative regulation of interleukin-6 biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|negative regulation of B cell activation|leukocyte migration|cilium assembly|lung epithelium development|epithelium development|left/right pattern formation|glomerular parietal epithelial cell development|activation of GTPase activity|positive regulation of lung ciliated cell differentiation FOXJ2 506.768753425009 487.71775314436 525.819753705658 1.07812305440114 0.108521853268962 0.536932717370999 1 2.59163 2.62108 2.79772 2.82551 GeneID:55810,Genbank:XM_011520760.2,HGNC:HGNC:24818 forkhead box J2 GO:0000978,GO:0001077,GO:0001650,GO:0005634,GO:0009653,GO:0030154,GO:0042802,GO:0043565,GO:0045893,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|fibrillar center|nucleus|anatomical structure morphogenesis|cell differentiation|identical protein binding|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter FOXJ3 1198.39033889763 1223.90541373108 1172.87526406419 0.958305479251594 -0.0614424773906775 0.699657674160059 1 6.75927 6.12588 6.93741 5.69892 GeneID:22887,Genbank:NM_001198850.1,HGNC:HGNC:29178,MIM:616035 forkhead box J3 GO:0000981,GO:0001228,GO:0005634,GO:0009653,GO:0030154,GO:0043565,GO:0045944 RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter FOXK1 1489.14781445478 1553.99876523882 1424.29686367074 0.916536676560262 -0.125735481407641 0.372331049984961 1 6.15221 6.64704 5.9135 5.9076 GeneID:221937,Genbank:XM_011515191.3,HGNC:HGNC:23480,MIM:616302 forkhead box K1 GO:0000977,GO:0000981,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0007517,GO:0009653,GO:0016579,GO:0030154,GO:0045892,GO:0045893 RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|muscle organ development|anatomical structure morphogenesis|protein deubiquitination|cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated FOXK2 3076.99916377177 2876.88000185593 3277.11832568762 1.13912235601536 0.187922718894919 0.175811206503041 1 22.755 24.4727 28.3842 26.0811 GeneID:3607,Genbank:NM_004514.3,HGNC:HGNC:6036,MIM:147685 forkhead box K2 GO:0000287,GO:0000978,GO:0001077,GO:0003700,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0009653,GO:0016579,GO:0030154,GO:0043565,GO:0045944 magnesium ion binding|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|anatomical structure morphogenesis|protein deubiquitination|cell differentiation|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter FOXL1 10.9980646371424 8.42726638264504 13.5688628916398 1.61011439244205 0.687163189921397 0.503307114199079 1 0.035865 0.19178 0.150428 0.234379 GeneID:2300,Genbank:NM_005250.2,HGNC:HGNC:3817,MIM:603252 forkhead box L1 GO:0000981,GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0007275,GO:0007495,GO:0007507,GO:0008301,GO:0009653,GO:0030111,GO:0030154,GO:0030166,GO:0043565,GO:0061146 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|multicellular organism development|visceral mesoderm-endoderm interaction involved in midgut development|heart development|DNA binding, bending|anatomical structure morphogenesis|regulation of Wnt signaling pathway|cell differentiation|proteoglycan biosynthetic process|sequence-specific DNA binding|Peyer's patch morphogenesis FOXL2NB 1.94146980195368 0.490071401957362 3.39286820195 6.92321198176177 2.79144152269665 0.357470692807481 1 0 0.01045 0.0217751 0.0304861 GeneID:401089,Genbank:NM_001040061.2,HGNC:HGNC:34428 FOXL2 neighbor GO:0001650 fibrillar center FOXM1 7433.28008670843 7151.52102727481 7715.03914614205 1.07879696035544 0.109423361719232 0.411179607014288 1 59.127 61.2279 69.1763 62.5295 GeneID:2305,Genbank:XM_011520930.3,HGNC:HGNC:3818,MIM:602341 forkhead box M1 hsa04218 Cellular senescence FOXN1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00738621 0 0 GeneID:8456,Genbank:XM_017025228.1,HGNC:HGNC:12765,MIM:600838 forkhead box N1 FOXN2 87.1921895709581 102.163140323739 72.2212388181777 0.706920701432241 -0.500379704558218 0.285590070701505 1 0.860171 0.600062 0.603916 0.427338 GeneID:3344,Genbank:XM_005264282.2,HGNC:HGNC:5281,MIM:143089 forkhead box N2 GO:0003700,GO:0005634,GO:0006351,GO:0030154,GO:0035914,GO:0043231,GO:0043565,GO:0045893 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|cell differentiation|skeletal muscle cell differentiation|intracellular membrane-bounded organelle|sequence-specific DNA binding|positive regulation of transcription, DNA-templated FOXN3 2484.54409295202 2387.63013157249 2581.45805433155 1.0811800455171 0.112606790552411 0.571457457342471 1 11.5996 11.0097 14.2985 10.4161 GeneID:1112,Genbank:NM_001085471.1,HGNC:HGNC:1928,MIM:602628 forkhead box N3 GO:0003700,GO:0005634,GO:0006351,GO:0007095,GO:0008022,GO:0030154,GO:0043565,GO:0045892,GO:0045893,GO:0097094 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|mitotic G2 DNA damage checkpoint|protein C-terminus binding|cell differentiation|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|craniofacial suture morphogenesis FOXO1 216.249733499046 219.730216517111 212.769250480981 0.968320396955566 -0.0464436107981178 0.860720632436813 1 1.00374 0.88964 1.04136 0.824747 GeneID:2308,Genbank:NM_002015.3,HGNC:HGNC:3819,MIM:136533 forkhead box O1 hsa04068,hsa04152,hsa04211,hsa04213,hsa04218,hsa04910,hsa04919,hsa04922,hsa04931,hsa04933,hsa05165,hsa05200,hsa05202,hsa05215 FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Insulin signaling pathway|Thyroid hormone signaling pathway|Glucagon signaling pathway|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Human papillomavirus infection|Pathways in cancer|Transcriptional misregulation in cancer|Prostate cancer FOXO3 1213.45044985725 1318.4205337231 1108.48036599141 0.840763881961972 -0.250227400413105 0.156774971058435 1 4.14637 3.95527 3.99988 2.87077 GeneID:2309,Genbank:NM_201559.2,HGNC:HGNC:3821,MIM:602681 forkhead box O3 hsa01521,hsa04062,hsa04068,hsa04137,hsa04151,hsa04152,hsa04211,hsa04213,hsa04218,hsa04722,hsa04917,hsa05213,hsa05223 EGFR tyrosine kinase inhibitor resistance|Chemokine signaling pathway|FoxO signaling pathway|Mitophagy - animal|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Neurotrophin signaling pathway|Prolactin signaling pathway|Endometrial cancer|Non-small cell lung cancer FOXO4 184.361887729961 161.797963883374 206.925811576547 1.27891480591005 0.354920163215059 0.171509251689733 1 1.35105 1.95986 2.12396 2.08413 GeneID:4303,Genbank:NM_005938.3,HGNC:HGNC:7139,MIM:300033 forkhead box O4 hsa04014,hsa04068 Ras signaling pathway|FoxO signaling pathway FOXO6 6.72697925207117 7.63922867747008 5.81472982667226 0.761167137700864 -0.393714818219485 0.776649211692752 1 0.137388 0.134794 0.123621 0.116357 GeneID:100132074,Genbank:NM_001291281.2,HGNC:HGNC:24814,MIM:611457 forkhead box O6 GO:0000981,GO:0005634,GO:0005737,GO:0006351,GO:0006357,GO:0007613,GO:0009653,GO:0043565,GO:0060999 RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|memory|anatomical structure morphogenesis|sequence-specific DNA binding|positive regulation of dendritic spine development hsa04068 FoxO signaling pathway FOXP1 463.893625506733 482.873857053725 444.913393959741 0.9213863775405 -0.118121826660939 0.53397413002751 1 1.36072 1.19223 1.29098 1.10378 GeneID:27086,Genbank:NM_001244810.1,HGNC:HGNC:3823,MIM:605515 forkhead box P1 GO:0000122,GO:0000978,GO:0001078,GO:0001701,GO:0002053,GO:0002329,GO:0002639,GO:0002903,GO:0003677,GO:0003682,GO:0003700,GO:0003705,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0007507,GO:0007519,GO:0008045,GO:0008134,GO:0010595,GO:0021517,GO:0021756,GO:0030316,GO:0030324,GO:0032496,GO:0032680,GO:0033152,GO:0033574,GO:0035926,GO:0036035,GO:0042116,GO:0042117,GO:0042118,GO:0042803,GO:0043621,GO:0045214,GO:0045655,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0046982,GO:0048661,GO:0048745,GO:0050679,GO:0055007,GO:0060043,GO:0060766,GO:0061052,GO:0061140,GO:0061470,GO:0071356,GO:0072358,GO:0072619,GO:1900424,GO:1901249,GO:1901250,GO:1901256,GO:1904637,GO:1905206,GO:2000727 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|in utero embryonic development|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|positive regulation of immunoglobulin production|negative regulation of B cell apoptotic process|DNA binding|chromatin binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|heart development|skeletal muscle tissue development|motor neuron axon guidance|transcription factor binding|positive regulation of endothelial cell migration|ventral spinal cord development|striatum development|osteoclast differentiation|lung development|response to lipopolysaccharide|regulation of tumor necrosis factor production|immunoglobulin V(D)J recombination|response to testosterone|chemokine (C-C motif) ligand 2 secretion|osteoclast development|macrophage activation|monocyte activation|endothelial cell activation|protein homodimerization activity|protein self-association|sarcomere organization|regulation of monocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|protein heterodimerization activity|positive regulation of smooth muscle cell proliferation|smooth muscle tissue development|positive regulation of epithelial cell proliferation|cardiac muscle cell differentiation|regulation of cardiac muscle cell proliferation|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth involved in cardiac muscle cell development|lung secretory cell differentiation|T follicular helper cell differentiation|cellular response to tumor necrosis factor|cardiovascular system development|interleukin-21 secretion|regulation of defense response to bacterium|regulation of lung goblet cell differentiation|negative regulation of lung goblet cell differentiation|regulation of macrophage colony-stimulating factor production|cellular response to ionomycin|positive regulation of hydrogen peroxide-induced cell death|positive regulation of cardiac muscle cell differentiation hsa05206 MicroRNAs in cancer FOXP2 1.72545033768766 1.02816907859967 2.42273159677566 2.35635524078913 1.23655705423232 0.731221338003923 1 0 0.00530975 0.0106991 0.00995251 GeneID:93986,Genbank:XM_017012801.2,HGNC:HGNC:13875,MIM:605317 forkhead box P2 GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0009653,GO:0021757,GO:0021758,GO:0030154,GO:0042803,GO:0043565,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|anatomical structure morphogenesis|caudate nucleus development|putamen development|cell differentiation|protein homodimerization activity|sequence-specific DNA binding|metal ion binding FOXP3 2.02101386303638 2.10436443188427 1.93766329418849 0.920783142325533 -0.119066673999736 1 1 0.0271242 0.0117138 0.012499 0.0234542 GeneID:50943,Genbank:XM_006724533.2,HGNC:HGNC:6106,MIM:300292 forkhead box P3 hsa04659,hsa05321 Th17 cell differentiation|Inflammatory bowel disease (IBD) FOXP4 471.714113431787 390.445518185087 552.982708678486 1.41628648024678 0.502113116994279 0.00486176026442402 0.278092687125054 1.68041 1.77833 2.47829 2.23151 GeneID:116113,Genbank:NM_001012426.1,HGNC:HGNC:20842,MIM:608924 forkhead box P4 GO:0000981,GO:0005634,GO:0006351,GO:0009653,GO:0030154,GO:0043565,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleus|transcription, DNA-templated|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding|metal ion binding FOXQ1 5.88798833115835 4.01662376502878 7.75935289728793 1.93180973653686 0.949953010492719 0.624705312127509 1 0.0378563 0.129562 0.451496 0.03245 GeneID:94234,Genbank:NM_033260.3,HGNC:HGNC:20951,MIM:612788 forkhead box Q1 GO:0000978,GO:0000981,GO:0001078,GO:0005634,GO:0006351,GO:0009653,GO:0030154,GO:0031069 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|transcription, DNA-templated|anatomical structure morphogenesis|cell differentiation|hair follicle morphogenesis FOXR1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0181956 GeneID:283150,Genbank:XM_017017576.1,HGNC:HGNC:29980,MIM:615755 forkhead box R1 GO:0000981,GO:0005634,GO:0006351,GO:0009653,GO:0030154,GO:0043565 RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleus|transcription, DNA-templated|anatomical structure morphogenesis|cell differentiation|sequence-specific DNA binding FOXRED1 814.31246947298 798.504180875316 830.120758070643 1.03959475473337 0.0560212598353638 0.736107213610008 1 5.59505 6.05809 5.72514 6.43512 GeneID:55572,Genbank:NM_017547.3,HGNC:HGNC:26927,MIM:613622 FAD dependent oxidoreductase domain containing 1 GO:0005739,GO:0005743,GO:0005747,GO:0016021,GO:0016491,GO:0032981 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|integral component of membrane|oxidoreductase activity|mitochondrial respiratory chain complex I assembly FOXRED2 1255.64798480915 1169.33805132786 1341.95791829045 1.1476218675742 0.19864736358196 0.188686938720958 1 8.9033 9.84367 11.3117 10.4934 GeneID:80020,Genbank:NM_001102371.1,HGNC:HGNC:26264,MIM:613777 FAD dependent oxidoreductase domain containing 2 GO:0005788,GO:0016491,GO:0030433,GO:0050660 endoplasmic reticulum lumen|oxidoreductase activity|ubiquitin-dependent ERAD pathway|flavin adenine dinucleotide binding FOXS1 9.65273789145118 15.9126075809524 3.39286820195 0.213218869672329 -2.22959297396643 0.0243966745762595 0.624239560191094 0.662045 0.595666 0.160354 0.188153 GeneID:2307,Genbank:NM_004118.3,HGNC:HGNC:3735,MIM:602939 forkhead box S1 GO:0000978,GO:0000981,GO:0001078,GO:0001568,GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0009653,GO:0030154,GO:0040018,GO:0043433,GO:0045892,GO:0050885 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|blood vessel development|DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|anatomical structure morphogenesis|cell differentiation|positive regulation of multicellular organism growth|negative regulation of DNA binding transcription factor activity|negative regulation of transcription, DNA-templated|neuromuscular process controlling balance FPGS 1433.71940610195 1432.02104642784 1435.41776577606 1.00237197585657 0.00341798571622341 1 1 18.9979 18.737 18.9787 19.4633 GeneID:2356,Genbank:NM_004957.5,HGNC:HGNC:3824,MIM:136510 folylpolyglutamate synthase GO:0001889,GO:0004326,GO:0005524,GO:0005737,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006139,GO:0006536,GO:0006730,GO:0006760,GO:0007420,GO:0008283,GO:0031100,GO:0046655,GO:0046872,GO:0046901 liver development|tetrahydrofolylpolyglutamate synthase activity|ATP binding|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|nucleobase-containing compound metabolic process|glutamate metabolic process|one-carbon metabolic process|folic acid-containing compound metabolic process|brain development|cell proliferation|animal organ regeneration|folic acid metabolic process|metal ion binding|tetrahydrofolylpolyglutamate biosynthetic process hsa00790,hsa01523 Folate biosynthesis|Antifolate resistance FPGT 85.8992329623503 70.0115498941472 101.786916030553 1.45385891591385 0.539887275318681 0.0870623809178918 0.967672357727583 0.99798 0.991567 1.56181 1.21696 GeneID:8790,Genbank:NM_003838.4,HGNC:HGNC:3825,MIM:603609 fucose-1-phosphate guanylyltransferase GO:0003824,GO:0005525,GO:0005737,GO:0005829,GO:0006004,GO:0047341 catalytic activity|GTP binding|cytoplasm|cytosol|fucose metabolic process|fucose-1-phosphate guanylyltransferase activity hsa00051,hsa00520 Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism FPR1 9.74869166900484 15.1343785308853 4.36300480712434 0.288284371784449 -1.79443546603305 0.0582184162535945 0.875517516166731 0.319796 0.444604 0.16654 0.0619849 GeneID:2357,Genbank:NM_001193306.1,HGNC:HGNC:3826,MIM:136537 formyl peptide receptor 1 hsa04015,hsa04080,hsa05150 Rap1 signaling pathway|Neuroactive ligand-receptor interaction|Staphylococcus aureus infection FPR3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0132716 GeneID:2359,Genbank:NM_002030.4,HGNC:HGNC:3828,MIM:136539 formyl peptide receptor 3 GO:0002430,GO:0004875,GO:0004982,GO:0005886,GO:0005887,GO:0006928,GO:0006954,GO:0007165,GO:0007186,GO:0007200,GO:0007204,GO:0016021,GO:0050900,GO:0060326 complement receptor mediated signaling pathway|complement receptor activity|N-formyl peptide receptor activity|plasma membrane|integral component of plasma membrane|movement of cell or subcellular component|inflammatory response|signal transduction|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|integral component of membrane|leukocyte migration|cell chemotaxis hsa04080,hsa05150 Neuroactive ligand-receptor interaction|Staphylococcus aureus infection FRA10AC1 203.274898786767 214.14732599684 192.402471576694 0.898458435943921 -0.154476330879004 0.516022363667208 1 1.90742 1.58909 1.75789 1.55276 GeneID:118924,Genbank:NM_001347714.1,HGNC:HGNC:1162,MIM:608866 FRA10A associated CGG repeat 1 GO:0005634 nucleus FRAS1 1169.1898974013 1096.52913484516 1241.85065995744 1.13252864925727 0.179547546181975 0.561087043447372 1 2.11981 2.19991 3.10244 1.92024 GeneID:80144,Genbank:XM_006714316.3,HGNC:HGNC:19185,MIM:607830 Fraser extracellular matrix complex subunit 1 GO:0002009,GO:0003338,GO:0005886,GO:0007154,GO:0015031,GO:0016021,GO:0030326,GO:0043588,GO:0046872,GO:0060021,GO:0061618 morphogenesis of an epithelium|metanephros morphogenesis|plasma membrane|cell communication|protein transport|integral component of membrane|embryonic limb morphogenesis|skin development|metal ion binding|palate development|sublamina densa FRAT1 55.3739074766044 53.5706532916605 57.1771616615483 1.06732246385446 0.0939961149814414 0.845832708840352 1 1.15193 1.37682 1.16154 1.58 GeneID:10023,Genbank:NM_005479.3,HGNC:HGNC:3944,MIM:602503 FRAT1, WNT signaling pathway regulator GO:0005829,GO:0043231,GO:1904886 cytosol|intracellular membrane-bounded organelle|beta-catenin destruction complex disassembly hsa04310,hsa05200,hsa05224,hsa05225,hsa05226 Wnt signaling pathway|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer FRAT2 419.886421935278 364.346255366654 475.426588503903 1.30487573702511 0.383912425865313 0.0319811187678135 0.70845034327151 10.5937 8.556 13.0897 12.3708 GeneID:23401,Genbank:NM_012083.2,HGNC:HGNC:16048,MIM:605006 FRAT2, WNT signaling pathway regulator GO:0005829,GO:0007275,GO:0008283,GO:1904886 cytosol|multicellular organism development|cell proliferation|beta-catenin destruction complex disassembly hsa04310,hsa05200,hsa05224,hsa05225,hsa05226 Wnt signaling pathway|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer FREM1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:158326,Genbank:NM_144966.5,HGNC:HGNC:23399,MIM:608944 FRAS1 related extracellular matrix 1 FREM2 121.842959687979 103.595136910034 140.090782465925 1.35229110790776 0.435405754228877 0.324234925145423 1 0.248848 0.213133 0.403871 0.228177 GeneID:341640,Genbank:NM_207361.5,HGNC:HGNC:25396,MIM:608945 FRAS1 related extracellular matrix protein 2 GO:0002009,GO:0005604,GO:0005886,GO:0007154,GO:0007155,GO:0007507,GO:0016021,GO:0046872,GO:0048839,GO:0070062 morphogenesis of an epithelium|basement membrane|plasma membrane|cell communication|cell adhesion|heart development|integral component of membrane|metal ion binding|inner ear development|extracellular exosome FREM3 1.51280239516014 2.05633815719933 0.969266633120943 0.471355661872779 -1.08511203720016 0.811646606184739 1 0.00975516 0.00897296 0 0 GeneID:166752,Genbank:NM_001168235.1,HGNC:HGNC:25172,MIM:608946 FRAS1 related extracellular matrix 3 GO:0005604,GO:0005615,GO:0007154,GO:0007155,GO:0016021,GO:0046872 basement membrane|extracellular space|cell communication|cell adhesion|integral component of membrane|metal ion binding FRG1 408.541526216925 438.105888687936 378.977163745915 0.865035539423807 -0.209168688730811 0.259390173756419 1 12.5346 12.2877 10.7382 10.0675 GeneID:2483,Genbank:NM_004477.2,HGNC:HGNC:3954,MIM:601278 FSHD region gene 1 GO:0000398,GO:0003723,GO:0005730,GO:0006364,GO:0007517,GO:0015030,GO:0030018,GO:0051015,GO:0055120,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleolus|rRNA processing|muscle organ development|Cajal body|Z disc|actin filament binding|striated muscle dense body|catalytic step 2 spliceosome FRK 9.6368586212872 12.9721791692082 6.30153807336622 0.485773283822973 -1.04164494693906 0.286901353332391 1 0.120798 0.0447669 0.0448715 0.0416756 GeneID:2444,Genbank:XM_011535656.2,HGNC:HGNC:3955,MIM:606573 fyn related Src family tyrosine kinase GO:0000122,GO:0004713,GO:0004715,GO:0005102,GO:0005524,GO:0005576,GO:0005622,GO:0005634,GO:0005829,GO:0006468,GO:0007169,GO:0008285,GO:0016477,GO:0030154,GO:0031234,GO:0035578,GO:0035580,GO:0038083,GO:0043312,GO:0045087,GO:0070062 negative regulation of transcription from RNA polymerase II promoter|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|receptor binding|ATP binding|extracellular region|intracellular|nucleus|cytosol|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|negative regulation of cell proliferation|cell migration|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|azurophil granule lumen|specific granule lumen|peptidyl-tyrosine autophosphorylation|neutrophil degranulation|innate immune response|extracellular exosome FRMD1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:79981,Genbank:XM_011536143.1,HGNC:HGNC:21240 FERM domain containing 1 GO:0005856 cytoskeleton hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species FRMD3 87.6732039887781 84.7038832977601 90.642524679796 1.07011061536765 0.0977599330695168 0.769960968328731 1 0.215058 0.260788 0.378479 0.209995 GeneID:257019,Genbank:NM_001244959.1,HGNC:HGNC:24125,MIM:607619 FERM domain containing 3 GO:0005200,GO:0005856,GO:0008092,GO:0016021,GO:0031032 structural constituent of cytoskeleton|cytoskeleton|cytoskeletal protein binding|integral component of membrane|actomyosin structure organization FRMD4A 923.650086536478 1033.04138365477 814.258789418184 0.788215072795476 -0.343338756932336 0.0268868839085621 0.657435622411498 1.53328 1.55872 1.38215 1.09511 GeneID:55691,Genbank:XM_017016394.2,HGNC:HGNC:25491,MIM:616305 FERM domain containing 4A GO:0005737,GO:0005856,GO:0005912,GO:0005923,GO:0030674,GO:0090162 cytoplasm|cytoskeleton|adherens junction|bicellular tight junction|protein binding, bridging|establishment of epithelial cell polarity FRMD4B 15.7781489080578 19.4391599440238 12.1171378720919 0.623336497409554 -0.681916907422971 0.351178665964214 1 0.0508644 0.0806777 0.0447366 0.0265233 GeneID:23150,Genbank:NM_015123.2,HGNC:HGNC:24886,MIM:617467 FERM domain containing 4B GO:0001726,GO:0005615,GO:0005737,GO:0005856,GO:0005912,GO:0005923,GO:0090162 ruffle|extracellular space|cytoplasm|cytoskeleton|adherens junction|bicellular tight junction|establishment of epithelial cell polarity FRMD5 1558.37001601691 1615.30164875476 1501.43838327906 0.929509596202372 -0.105458335367017 0.479069053339292 1 9.54927 8.87813 9.35302 8.04445 GeneID:84978,Genbank:NM_001322951.1,HGNC:HGNC:28214,MIM:616309 FERM domain containing 5 GO:0005178,GO:0005200,GO:0005856,GO:0005912,GO:0008092,GO:0016021,GO:0019901,GO:0030334,GO:0031032,GO:0045785,GO:2000146 integrin binding|structural constituent of cytoskeleton|cytoskeleton|adherens junction|cytoskeletal protein binding|integral component of membrane|protein kinase binding|regulation of cell migration|actomyosin structure organization|positive regulation of cell adhesion|negative regulation of cell motility FRMD6 611.323867646141 635.225177130107 587.422558162175 0.924746970540588 -0.112869425781109 0.614463764106769 1 3.93705 3.16726 3.60523 2.84267 GeneID:122786,Genbank:XM_011536424.1,HGNC:HGNC:19839,MIM:614555 FERM domain containing 6 GO:0003383,GO:0005200,GO:0005737,GO:0005856,GO:0005886,GO:0031032,GO:0032970,GO:0034613,GO:0043296 apical constriction|structural constituent of cytoskeleton|cytoplasm|cytoskeleton|plasma membrane|actomyosin structure organization|regulation of actin filament-based process|cellular protein localization|apical junction complex hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species FRMD7 16.0796713704516 17.6229531602492 14.5363895806539 0.82485548525673 -0.27778671366973 0.747771906901996 1 0.116049 0.0750985 0.049854 0.0928879 GeneID:90167,Genbank:XM_017029948.2,HGNC:HGNC:8079,MIM:300628 FERM domain containing 7 GO:0005615,GO:0005856,GO:0010592,GO:0010975,GO:0030426,GO:0032091,GO:0043005,GO:0043025,GO:0051057,GO:0051497 extracellular space|cytoskeleton|positive regulation of lamellipodium assembly|regulation of neuron projection development|growth cone|negative regulation of protein binding|neuron projection|neuronal cell body|positive regulation of small GTPase mediated signal transduction|negative regulation of stress fiber assembly FRMD8 847.895092777713 911.190160359331 784.600025196095 0.86107166136066 -0.215794786199646 0.161384311207982 1 12.3631 13.0456 11.0339 11.1347 GeneID:83786,Genbank:NM_031904.4,HGNC:HGNC:25462 FERM domain containing 8 GO:0005856 cytoskeleton FRMPD1 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0 0 0 0.0039651 GeneID:22844,Genbank:XM_011517803.3,HGNC:HGNC:29159,MIM:616919 FERM and PDZ domain containing 1 GO:0005829,GO:0005856,GO:0005886,GO:0008277,GO:0043234,GO:0070062,GO:0090150 cytosol|cytoskeleton|plasma membrane|regulation of G-protein coupled receptor protein signaling pathway|protein complex|extracellular exosome|establishment of protein localization to membrane FRMPD3 11.3492674527065 10.5796570892143 12.1188778161987 1.14548871612801 0.195963247148622 0.895032631974575 1 0.0261272 0.0647538 0.0779217 0.0410574 GeneID:84443,Genbank:NM_032428.2,HGNC:HGNC:29382,MIM:301005 FERM and PDZ domain containing 3 GO:0005856,GO:0005886,GO:0030667,GO:0043312,GO:0070821 cytoskeleton|plasma membrane|secretory granule membrane|neutrophil degranulation|tertiary granule membrane FRMPD4 17.0380843336324 19.0451410914363 15.0310275758285 0.789231621003177 -0.341479335289936 0.681899914708247 1 0.0815852 0.0680087 0.0818341 0.0267028 GeneID:9758,Genbank:XM_017029983.1,HGNC:HGNC:29007,MIM:300838 FERM and PDZ domain containing 4 GO:0005546,GO:0005856,GO:0043197,GO:0043234,GO:0051835 phosphatidylinositol-4,5-bisphosphate binding|cytoskeleton|dendritic spine|protein complex|positive regulation of synapse structural plasticity FRRS1 111.645079997964 92.4391645246001 130.850995471327 1.41553632753253 0.50134877423731 0.0776414671623476 0.94157495521624 1.04519 1.06023 1.3617 1.47413 GeneID:391059,Genbank:XM_005270861.3,HGNC:HGNC:27622,MIM:611578 ferric chelate reductase 1 GO:0000293,GO:0016021,GO:0046872 ferric-chelate reductase activity|integral component of membrane|metal ion binding FRS2 209.091248451083 241.263932237911 176.918564664254 0.733298852518884 -0.447526813066052 0.115241742305435 1 1.35345 1.25654 1.19784 0.7467 GeneID:10818,Genbank:NM_001042555.2,HGNC:HGNC:16971,MIM:607743 fibroblast growth factor receptor substrate 2 GO:0000165,GO:0000186,GO:0000187,GO:0001702,GO:0001759,GO:0003281,GO:0005068,GO:0005088,GO:0005104,GO:0005168,GO:0005768,GO:0005886,GO:0005887,GO:0005913,GO:0007185,GO:0007186,GO:0007405,GO:0007411,GO:0008543,GO:0008595,GO:0016020,GO:0016303,GO:0019211,GO:0030900,GO:0042981,GO:0046619,GO:0046934,GO:0050678,GO:0051897,GO:0060527,GO:0070307,GO:0070372,GO:2000726 MAPK cascade|activation of MAPKK activity|activation of MAPK activity|gastrulation with mouth forming second|organ induction|ventricular septum development|transmembrane receptor protein tyrosine kinase adaptor activity|Ras guanyl-nucleotide exchange factor activity|fibroblast growth factor receptor binding|neurotrophin TRKA receptor binding|endosome|plasma membrane|integral component of plasma membrane|cell-cell adherens junction|transmembrane receptor protein tyrosine phosphatase signaling pathway|G-protein coupled receptor signaling pathway|neuroblast proliferation|axon guidance|fibroblast growth factor receptor signaling pathway|anterior/posterior axis specification, embryo|membrane|1-phosphatidylinositol-3-kinase activity|phosphatase activator activity|forebrain development|regulation of apoptotic process|optic placode formation involved in camera-type eye formation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|regulation of epithelial cell proliferation|positive regulation of protein kinase B signaling|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|lens fiber cell development|regulation of ERK1 and ERK2 cascade|negative regulation of cardiac muscle cell differentiation hsa04714,hsa04722,hsa05205 Thermogenesis|Neurotrophin signaling pathway|Proteoglycans in cancer FRS3 94.2925280508724 95.543289070615 93.04176703113 0.973817919983515 -0.0382760458787231 0.890535843433339 1 0.636253 1.02111 0.829454 0.909409 GeneID:10817,Genbank:NM_006653.4,HGNC:HGNC:16970,MIM:607744 fibroblast growth factor receptor substrate 3 GO:0000165,GO:0005088,GO:0005104,GO:0005622,GO:0005886,GO:0007165,GO:0008543,GO:0042802 MAPK cascade|Ras guanyl-nucleotide exchange factor activity|fibroblast growth factor receptor binding|intracellular|plasma membrane|signal transduction|fibroblast growth factor receptor signaling pathway|identical protein binding FRY 70.1103996989822 67.032903862826 73.1878955351385 1.09182045409979 0.126735629813679 0.740266234172906 1 0.119021 0.147089 0.158347 0.120533 GeneID:10129,Genbank:NM_023037.2,HGNC:HGNC:20367,MIM:614818 FRY microtubule binding protein GO:0000902,GO:0000922,GO:0004857,GO:0005815,GO:0005938,GO:0030427,GO:0031175,GO:0090527,GO:1904428 cell morphogenesis|spindle pole|enzyme inhibitor activity|microtubule organizing center|cell cortex|site of polarized growth|neuron projection development|actin filament reorganization|negative regulation of tubulin deacetylation FRYL 460.145872143074 502.409069547118 417.882674739029 0.831757824586481 -0.265764561865767 0.590944161958548 1 1.36148 1.16206 1.45878 0.700736 GeneID:285527,Genbank:NM_015030.1,HGNC:HGNC:29127 FRY like transcription coactivator FRZB 2.02438538477488 2.59443583384164 1.45433493570811 0.560559223218347 -0.835061292722276 0.824506951681651 1 0.0403509 0.0188481 0.0192367 0.0178832 GeneID:2487,Genbank:NM_001463.3,HGNC:HGNC:3959,MIM:605083 frizzled related protein FSCN1 6931.45393909433 6808.52045053363 7054.38742765502 1.03611166022159 0.051179488514167 0.720750862249733 1 140.201 144.397 146.093 155.349 GeneID:6624,Genbank:NM_003088.3,HGNC:HGNC:11148,MIM:602689 fascin actin-bundling protein 1 hsa05206 MicroRNAs in cancer FSCN2 20.5031018342112 20.6594341213632 20.3467695470592 0.98486577258277 -0.0220009819171525 1 1 0.072806 0.0867535 0.0380074 0.178166 GeneID:25794,Genbank:XM_011524590.2,HGNC:HGNC:3960,MIM:607643 fascin actin-bundling protein 2, retinal FSCN3 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0249779 0 0.0232168 0 GeneID:29999,Genbank:NM_020369.2,HGNC:HGNC:3961,MIM:615800 fascin actin-bundling protein 3 GO:0001726,GO:0005737,GO:0005856,GO:0005902,GO:0007163,GO:0007286,GO:0009653,GO:0015629,GO:0016477,GO:0030027,GO:0030175,GO:0030426,GO:0030674,GO:0031253,GO:0031941,GO:0051015,GO:0051017 ruffle|cytoplasm|cytoskeleton|microvillus|establishment or maintenance of cell polarity|spermatid development|anatomical structure morphogenesis|actin cytoskeleton|cell migration|lamellipodium|filopodium|growth cone|protein binding, bridging|cell projection membrane|filamentous actin|actin filament binding|actin filament bundle assembly FSD1 463.126938161525 466.347733557831 459.90614276522 0.986187151069724 -0.0200666386501843 0.89566389160907 1 9.15333 10.2694 10.1095 9.70705 GeneID:79187,Genbank:NM_024333.2,HGNC:HGNC:13745,MIM:609828 fibronectin type III and SPRY domain containing 1 GO:0005634,GO:0005737,GO:0005813,GO:0005874,GO:0007049,GO:0008017,GO:0031122,GO:0032154,GO:0032465,GO:0042803,GO:0051260,GO:0051301,GO:0051302,GO:0060236 nucleus|cytoplasm|centrosome|microtubule|cell cycle|microtubule binding|cytoplasmic microtubule organization|cleavage furrow|regulation of cytokinesis|protein homodimerization activity|protein homooligomerization|cell division|regulation of cell division|regulation of mitotic spindle organization FSD1L 19.9116706648159 21.3994455518532 18.4238957777785 0.860952015468595 -0.215995262578392 0.779181733873574 1 0.0849128 0.106214 0.132355 0.046126 GeneID:83856,Genbank:XM_017015185.1,HGNC:HGNC:13753,MIM:609829 fibronectin type III and SPRY domain containing 1 like GO:0005622 intracellular FSD2 5.99818020658542 7.14915727551272 4.84720313765811 0.678010421488522 -0.560620646135981 0.688982396299649 1 0.0136599 0.0173051 0.0130959 0.00406955 GeneID:123722,Genbank:NM_001281806.1,HGNC:HGNC:18024 fibronectin type III and SPRY domain containing 2 FSHR 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.00264929 0 0 GeneID:2492,Genbank:XM_011532734.2,HGNC:HGNC:3969,MIM:136435 follicle stimulating hormone receptor hsa04024,hsa04080,hsa04913 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Ovarian steroidogenesis FSIP1 36.759588907574 43.961330351253 29.5578474638951 0.672360168077866 -0.572693835837786 0.236505113801153 1 0.177171 0.134975 0.0908001 0.151093 GeneID:161835,Genbank:XM_011521305.3,HGNC:HGNC:21674,MIM:615795 fibrous sheath interacting protein 1 FSIP2 4.6209832425552 2.94042841174417 6.30153807336622 2.14306801287787 1.09967763642818 0.50406110849728 1 0 0.00837592 0.0131625 0.0076444 GeneID:401024,Genbank:XM_024452886.1,HGNC:HGNC:21675,MIM:615796 fibrous sheath interacting protein 2 GO:0005739 mitochondrion FST 115.331106530781 116.779038488197 113.883174573364 0.975202194226608 -0.0362267228296838 0.907313535813553 1 1.09509 1.18625 1.18372 1.17761 GeneID:10468,Genbank:XM_017008954.1,HGNC:HGNC:3971,MIM:136470 follistatin hsa04350 TGF-beta signaling pathway FSTL1 5895.74311186813 5871.08084652669 5920.40537720956 1.00840126919936 0.0120698391227261 0.943079758241486 1 40.9347 42.1956 48.9096 36.3017 GeneID:11167,Genbank:NM_007085.4,HGNC:HGNC:3972,MIM:605547 follistatin like 1 GO:0005509,GO:0005576,GO:0005615,GO:0005788,GO:0008201,GO:0030509,GO:0042594,GO:0043687,GO:0044267,GO:0070062 calcium ion binding|extracellular region|extracellular space|endoplasmic reticulum lumen|heparin binding|BMP signaling pathway|response to starvation|post-translational protein modification|cellular protein metabolic process|extracellular exosome FSTL3 3553.31186685205 4315.96192766331 2790.6618060408 0.646590922907348 -0.629074840390382 0.000102048774738999 0.0230199038904199 76.1925 76.9558 46.1367 55.5418 GeneID:10272,Genbank:NM_005860.2,HGNC:HGNC:3973,MIM:605343 follistatin like 3 FSTL4 0.97013660517434 0 1.94027321034868 Inf Inf 0.496193947515089 1 0 0 0.0129434 0 GeneID:23105,Genbank:XM_011543283.1,HGNC:HGNC:21389 follistatin like 4 GO:0005509,GO:0005576,GO:0030141,GO:0031549,GO:0048403,GO:0048671,GO:0061000 calcium ion binding|extracellular region|secretory granule|negative regulation of brain-derived neurotrophic factor receptor signaling pathway|brain-derived neurotrophic factor binding|negative regulation of collateral sprouting|negative regulation of dendritic spine development FSTL5 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0160864 0 GeneID:56884,Genbank:NM_001128428.2,HGNC:HGNC:21386 follistatin like 5 GO:0005509,GO:0005576 calcium ion binding|extracellular region FTCD 2.70896466334088 3.47852608838648 1.93940323829528 0.557535918666886 -0.842863342745288 0.718040814685814 1 0 0.00836586 0.00888955 0 GeneID:10841,Genbank:XM_011529439.2,HGNC:HGNC:3974,MIM:606806 formimidoyltransferase cyclodeaminase GO:0000139,GO:0005542,GO:0005737,GO:0005783,GO:0005793,GO:0005794,GO:0005814,GO:0005829,GO:0005886,GO:0006548,GO:0006760,GO:0007010,GO:0008017,GO:0019556,GO:0019557,GO:0030407,GO:0030409,GO:0030412,GO:0030868,GO:0035999,GO:0070062 Golgi membrane|folic acid binding|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|centriole|cytosol|plasma membrane|histidine catabolic process|folic acid-containing compound metabolic process|cytoskeleton organization|microtubule binding|histidine catabolic process to glutamate and formamide|histidine catabolic process to glutamate and formate|formimidoyltransferase activity|glutamate formimidoyltransferase activity|formimidoyltetrahydrofolate cyclodeaminase activity|smooth endoplasmic reticulum membrane|tetrahydrofolate interconversion|extracellular exosome hsa00340,hsa00670 Histidine metabolism|One carbon pool by folate FTCDNL1 37.4889183993668 39.1184512614723 35.8593855372613 0.916687250667799 -0.125498486335198 0.822081401790893 1 0.0613414 0.059091 0.0459258 0.044497 GeneID:348751,Genbank:XM_024452853.1,HGNC:HGNC:48661,MIM:614308 formiminotransferase cyclodeaminase N-terminal like GO:0005542,GO:0008152,GO:0016740 folic acid binding|metabolic process|transferase activity FTH1 95386.5392598216 99260.631047578 91512.4474720652 0.921941020385021 -0.117253635251965 0.42960025464672 1 2883 3201.07 2667.02 3020.28 GeneID:2495,Genbank:NM_002032.2,HGNC:HGNC:3976,MIM:134770 ferritin heavy chain 1 hsa04216,hsa04217,hsa04978 Ferroptosis|Necroptosis|Mineral absorption FTL 98352.6878611526 92733.3743140897 103972.001408216 1.12119290576077 0.165034520999157 0.351130488439542 1 3899.5 3976.1 4087.84 4842.3 GeneID:2512,Genbank:XM_024451447.1,HGNC:HGNC:3999,MIM:134790 ferritin light chain hsa04216,hsa04217,hsa04978 Ferroptosis|Necroptosis|Mineral absorption FTO 2286.08127940029 2236.62456418814 2335.53799461244 1.0442244228236 0.062431806639353 0.64907294628734 1 5.28747 5.28515 5.87369 4.99079 GeneID:79068,Genbank:NM_001080432.2,HGNC:HGNC:24678,MIM:610966 FTO, alpha-ketoglutarate dependent dioxygenase GO:0001659,GO:0005634,GO:0005654,GO:0006307,GO:0008198,GO:0010883,GO:0016607,GO:0035515,GO:0035516,GO:0035552,GO:0035553,GO:0040014,GO:0042245,GO:0043734,GO:0044065,GO:0060612,GO:0070350,GO:0070989,GO:0080111,GO:0090335,GO:1990931 temperature homeostasis|nucleus|nucleoplasm|DNA dealkylation involved in DNA repair|ferrous iron binding|regulation of lipid storage|nuclear speck|oxidative RNA demethylase activity|oxidative DNA demethylase activity|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|regulation of multicellular organism growth|RNA repair|DNA-N1-methyladenine dioxygenase activity|regulation of respiratory system process|adipose tissue development|regulation of white fat cell proliferation|oxidative demethylation|DNA demethylation|regulation of brown fat cell differentiation|RNA N6-methyladenosine dioxygenase activity FTSJ1 1362.83992399894 1428.86112095374 1296.81872704414 0.907589063784264 -0.139888869878066 0.394253592778345 1 16.2433 19.8258 16.4716 17.1541 GeneID:24140,Genbank:NM_177439.2,HGNC:HGNC:13254,MIM:300499 FtsJ RNA methyltransferase homolog 1 GO:0002181,GO:0005737,GO:0005829,GO:0006400,GO:0008175,GO:0009020,GO:0030488,GO:0052666 cytoplasmic translation|cytoplasm|cytosol|tRNA modification|tRNA methyltransferase activity|tRNA (guanosine-2'-O-)-methyltransferase activity|tRNA methylation|tRNA (cytosine-2'-O-)-methyltransferase activity FTSJ3 2806.61453930253 2834.85628879973 2778.37278980534 0.980075357182108 -0.0290354137684769 0.837056993007897 1 18.28 17.9173 18.2356 17.4484 GeneID:117246,Genbank:NM_017647.3,HGNC:HGNC:17136 FtsJ RNA methyltransferase homolog 3 GO:0000463,GO:0000466,GO:0003723,GO:0005634,GO:0005730,GO:0008650,GO:0016435,GO:0030687,GO:0031167 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleolus|rRNA (uridine-2'-O-)-methyltransferase activity|rRNA (guanine) methyltransferase activity|preribosome, large subunit precursor|rRNA methylation FUBP1 1777.67079948672 1741.34300060461 1813.99859836883 1.04172388652838 0.0589729356553498 0.655910252858295 1 10.0816 9.98764 11.1772 10.3925 GeneID:8880,Genbank:XM_017002739.1,HGNC:HGNC:4004,MIM:603444 far upstream element binding protein 1 GO:0003697,GO:0003700,GO:0003723,GO:0005634,GO:0005654,GO:0006366,GO:0010628 single-stranded DNA binding|DNA binding transcription factor activity|RNA binding|nucleus|nucleoplasm|transcription from RNA polymerase II promoter|positive regulation of gene expression FUBP3 1725.41195938457 1906.35974189273 1544.4641768764 0.810164074983552 -0.303713981712158 0.0354402066785795 0.736200194765408 11.6954 10.2799 9.20733 9.10136 GeneID:8939,Genbank:NM_003934.1,HGNC:HGNC:4005,MIM:603536 far upstream element binding protein 3 GO:0000978,GO:0001077,GO:0003723,GO:0005634,GO:0005737,GO:0006351,GO:0010628,GO:0016020,GO:0045893,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA binding|nucleus|cytoplasm|transcription, DNA-templated|positive regulation of gene expression|membrane|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter FUCA1 1246.3103456078 1203.07450882205 1289.54618239354 1.0718755762319 0.100137446867191 0.504218550983334 1 12.1086 12.4212 13.4636 13.7018 GeneID:2517,Genbank:NM_000147.4,HGNC:HGNC:4006,MIM:612280 alpha-L-fucosidase 1 GO:0004560,GO:0005576,GO:0005737,GO:0006004,GO:0006027,GO:0016139,GO:0019377,GO:0035578,GO:0043202,GO:0043312,GO:0070062 alpha-L-fucosidase activity|extracellular region|cytoplasm|fucose metabolic process|glycosaminoglycan catabolic process|glycoside catabolic process|glycolipid catabolic process|azurophil granule lumen|lysosomal lumen|neutrophil degranulation|extracellular exosome hsa00511,hsa04142 Other glycan degradation|Lysosome FUCA2 5187.15866781273 4928.5880193753 5445.72931625017 1.1049268664457 0.143950882822324 0.284022473052 1 71.6508 77.9163 85.9226 82.7257 GeneID:2519,Genbank:NM_032020.4,HGNC:HGNC:4008,MIM:136820 alpha-L-fucosidase 2 GO:0004560,GO:0005576,GO:0005615,GO:0005788,GO:0006004,GO:0009617,GO:0016139,GO:0035578,GO:0043312,GO:0043687,GO:0044267,GO:0070062,GO:2000535 alpha-L-fucosidase activity|extracellular region|extracellular space|endoplasmic reticulum lumen|fucose metabolic process|response to bacterium|glycoside catabolic process|azurophil granule lumen|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|extracellular exosome|regulation of entry of bacterium into host cell hsa00511 Other glycan degradation FUK 239.799513142389 235.37428376017 244.224742524609 1.03760163864569 0.0532526630986946 0.829419254178336 1 1.68147 1.63933 1.50697 2.02596 GeneID:197258,Genbank:XM_017023013.2,HGNC:HGNC:29500,MIM:608675 fucokinase hsa00051,hsa00520 Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism FUNDC1 206.99209461078 209.006480603842 204.977708617718 0.980724176712202 -0.0280806514518997 0.931356682503225 1 7.41683 6.51783 6.09771 7.60713 GeneID:139341,Genbank:NM_173794.3,HGNC:HGNC:28746,MIM:300871 FUN14 domain containing 1 GO:0000422,GO:0001666,GO:0005741,GO:0010243,GO:0016236,GO:0031307 autophagy of mitochondrion|response to hypoxia|mitochondrial outer membrane|response to organonitrogen compound|macroautophagy|integral component of mitochondrial outer membrane hsa04137 Mitophagy - animal FUNDC2 2025.82964237753 2040.57369644585 2011.0855883092 0.98554910896479 -0.021000333720315 0.861588304390036 1 28.0977 33.1787 28.9559 31.7564 GeneID:65991,Genbank:NM_023934.3,HGNC:HGNC:24925 FUN14 domain containing 2 GO:0000422,GO:0005634,GO:0005739,GO:0031307 autophagy of mitochondrion|nucleus|mitochondrion|integral component of mitochondrial outer membrane FURIN 5247.49824273106 5491.90224693578 5003.09423852634 0.910994772588646 -0.13448531921577 0.30002702202365 1 46.8203 48.2379 43.1504 45.8289 GeneID:5045,Genbank:NM_002569.3,HGNC:HGNC:8568,MIM:136950 furin, paired basic amino acid cleaving enzyme hsa05164 Influenza A FUS 10669.1441520679 11034.6207218451 10303.6675822907 0.933758199943628 -0.0988790876777883 0.442676516830529 1 88.905 90.2137 87.6799 82.9579 GeneID:2521,Genbank:NM_004960.3,HGNC:HGNC:4010,MIM:137070 FUS RNA binding protein GO:0003677,GO:0003723,GO:0005634,GO:0005737,GO:0006355,GO:0046872 DNA binding|RNA binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|metal ion binding hsa05202 Transcriptional misregulation in cancer FUT1 5.68567320692282 7.49514985341526 3.87619656043037 0.517160648717936 -0.951315591702359 0.458652909306364 1 0.0390162 0.137936 0.036452 0.0568296 GeneID:2523,Genbank:NM_000148.3,HGNC:HGNC:4012,MIM:211100 fucosyltransferase 1 (H blood group) hsa00601,hsa00603 Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series FUT10 224.804099824384 230.069742232901 219.538457415867 0.954225685156056 -0.0675975746220074 0.77246816639014 1 1.62041 1.55509 1.62533 1.36821 GeneID:84750,Genbank:XM_011544676.3,HGNC:HGNC:19234,MIM:616931 fucosyltransferase 10 GO:0000139,GO:0005654,GO:0005783,GO:0005794,GO:0006457,GO:0006486,GO:0006605,GO:0007399,GO:0009566,GO:0016021,GO:0021799,GO:0030097,GO:0032580,GO:0042060,GO:0042355,GO:0046920,GO:0097150 Golgi membrane|nucleoplasm|endoplasmic reticulum|Golgi apparatus|protein folding|protein glycosylation|protein targeting|nervous system development|fertilization|integral component of membrane|cerebral cortex radially oriented cell migration|hemopoiesis|Golgi cisterna membrane|wound healing|L-fucose catabolic process|alpha-(1->3)-fucosyltransferase activity|neuronal stem cell population maintenance FUT11 787.630424676882 794.986420166498 780.274429187267 0.981494034858923 -0.026948595311659 0.877611265675192 1 13.1274 12.4438 12.9965 12.3442 GeneID:170384,Genbank:NM_001284194.1,HGNC:HGNC:19233,MIM:616932 fucosyltransferase 11 FUT2 1.70187218637189 0.980142803914724 2.42360156882906 2.47270250737863 1.30608867848779 0.73299311284869 1 0 0.0129226 0.0406075 0.025275 GeneID:2524,Genbank:NM_000511.5,HGNC:HGNC:4013,MIM:182100 fucosyltransferase 2 hsa00601,hsa00603 Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series FUT3 1.5397520682144 2.59443583384164 0.48506830258717 0.186964848488436 -2.41916104230609 0.49972398725951 1 0.0343679 0.0299754 0.0159029 0 GeneID:2525,Genbank:NM_001097641.1,HGNC:HGNC:4014,MIM:111100 fucosyltransferase 3 (Lewis blood group) hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series FUT4 23.889128220868 18.7089571686417 29.0692992730943 1.55376374060109 0.635767149706978 0.399486303791194 1 0.0978003 0.226152 0.185689 0.346255 GeneID:2526,Genbank:NM_002033.3,HGNC:HGNC:4015,MIM:104230 fucosyltransferase 4 hsa00515,hsa00601 Mannose type O-glycan biosynthesis|Glycosphingolipid biosynthesis - lacto and neolacto series FUT5 3.55913435361909 4.20872886376855 2.90953984346962 0.691310829860488 -0.532593568253355 0.84410906285695 1 0.164413 0.0466764 0.12605 0.0235356 GeneID:2527,Genbank:NM_002034.2,HGNC:HGNC:4016,MIM:136835 fucosyltransferase 5 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series FUT8 760.365412522063 800.06063897545 720.670186068676 0.900769455414729 -0.150770187616671 0.342460489778435 1 2.96837 2.97678 2.89091 2.52005 GeneID:2530,Genbank:NM_178155.2,HGNC:HGNC:4019,MIM:602589 fucosyltransferase 8 hsa00510,hsa00533,hsa05202 N-Glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Transcriptional misregulation in cancer FUT9 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00244835 0 0 0 GeneID:10690,Genbank:NM_006581.3,HGNC:HGNC:4020,MIM:606865 fucosyltransferase 9 GO:0000139,GO:0006486,GO:0016021,GO:0032580,GO:0046920 Golgi membrane|protein glycosylation|integral component of membrane|Golgi cisterna membrane|alpha-(1->3)-fucosyltransferase activity hsa00515,hsa00601,hsa00603 Mannose type O-glycan biosynthesis|Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series FUZ 231.487470518518 218.251210656986 244.72373038005 1.12129380470961 0.165164346886232 0.475343399815353 1 2.19462 2.98247 2.80663 3.09095 GeneID:80199,Genbank:XM_011527347.1,HGNC:HGNC:26219,MIM:610622 fuzzy planar cell polarity protein GO:0001736,GO:0001843,GO:0001942,GO:0005737,GO:0005856,GO:0008285,GO:0008589,GO:0010172,GO:0015031,GO:0030336,GO:0042995,GO:0045724,GO:0048704,GO:0060271,GO:0070062,GO:0090090,GO:0090301,GO:1905515,GO:2000314 establishment of planar polarity|neural tube closure|hair follicle development|cytoplasm|cytoskeleton|negative regulation of cell proliferation|regulation of smoothened signaling pathway|embryonic body morphogenesis|protein transport|negative regulation of cell migration|cell projection|positive regulation of cilium assembly|embryonic skeletal system morphogenesis|cilium assembly|extracellular exosome|negative regulation of canonical Wnt signaling pathway|negative regulation of neural crest formation|non-motile cilium assembly|negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation FXN 258.75705671432 289.732974757005 227.781138671635 0.786176094946293 -0.347075598114364 0.0918963785012547 0.985009977016794 1.11928 1.39884 1.0812 0.97466 GeneID:2395,Genbank:NM_181425.2,HGNC:HGNC:3951,MIM:606829 frataxin GO:0004322,GO:0005739,GO:0005759,GO:0005829,GO:0006119,GO:0006783,GO:0006811,GO:0006879,GO:0007005,GO:0007628,GO:0008198,GO:0008199,GO:0008284,GO:0009060,GO:0009792,GO:0010039,GO:0010722,GO:0016540,GO:0018283,GO:0019230,GO:0030307,GO:0034986,GO:0040015,GO:0043066,GO:0043085,GO:0044281,GO:0046621,GO:0051349,GO:0051536,GO:0051537,GO:0070301,GO:0090201,GO:1904231,GO:1904234 ferroxidase activity|mitochondrion|mitochondrial matrix|cytosol|oxidative phosphorylation|heme biosynthetic process|ion transport|cellular iron ion homeostasis|mitochondrion organization|adult walking behavior|ferrous iron binding|ferric iron binding|positive regulation of cell proliferation|aerobic respiration|embryo development ending in birth or egg hatching|response to iron ion|regulation of ferrochelatase activity|protein autoprocessing|iron incorporation into metallo-sulfur cluster|proprioception|positive regulation of cell growth|iron chaperone activity|negative regulation of multicellular organism growth|negative regulation of apoptotic process|positive regulation of catalytic activity|small molecule metabolic process|negative regulation of organ growth|positive regulation of lyase activity|iron-sulfur cluster binding|2 iron, 2 sulfur cluster binding|cellular response to hydrogen peroxide|negative regulation of release of cytochrome c from mitochondria|positive regulation of succinate dehydrogenase activity|positive regulation of aconitate hydratase activity hsa00860 Porphyrin and chlorophyll metabolism FXR1 2089.59740162249 2202.66352462732 1976.53127861767 0.897336908937143 -0.15627834207797 0.440769761272728 1 8.17302 7.39946 8.16694 6.13132 GeneID:8087,Genbank:NM_001013439.2,HGNC:HGNC:4023,MIM:600819 FMR1 autosomal homolog 1 GO:0002151,GO:0003723,GO:0003729,GO:0003730,GO:0005730,GO:0005737,GO:0005829,GO:0005844,GO:0006915,GO:0007517,GO:0016020,GO:0017148,GO:0030154,GO:0030424,GO:0033592,GO:0035770,GO:0042803,GO:0043034,GO:0043197,GO:0046982,GO:0048471,GO:2000637 G-quadruplex RNA binding|RNA binding|mRNA binding|mRNA 3'-UTR binding|nucleolus|cytoplasm|cytosol|polysome|apoptotic process|muscle organ development|membrane|negative regulation of translation|cell differentiation|axon|RNA strand annealing activity|ribonucleoprotein granule|protein homodimerization activity|costamere|dendritic spine|protein heterodimerization activity|perinuclear region of cytoplasm|positive regulation of gene silencing by miRNA hsa03013 RNA transport FXR2 2595.68960421785 2574.96964328744 2616.40956514827 1.01609336326308 0.0230329695591713 0.86512074323218 1 29.2701 27.843 29.1294 30.262 GeneID:9513,Genbank:NM_004860.3,HGNC:HGNC:4024,MIM:605339 FMR1 autosomal homolog 2 GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0016020,GO:0017148,GO:0022625,GO:0042802,GO:0042803,GO:0046982,GO:0070062 RNA binding|mRNA binding|nucleus|cytoplasm|cytosol|polysome|membrane|negative regulation of translation|cytosolic large ribosomal subunit|identical protein binding|protein homodimerization activity|protein heterodimerization activity|extracellular exosome hsa03013 RNA transport FXYD1 0.97013660517434 0 1.94027321034868 Inf Inf 0.496193947515089 1 0 0 0.0354458 0 GeneID:5348,Genbank:XM_017026874.2,HGNC:HGNC:4025,MIM:602359 FXYD domain containing ion transport regulator 1 GO:0005254,GO:0005886,GO:0005887,GO:0005890,GO:0005901,GO:0006813,GO:0006814,GO:0006821,GO:0006936,GO:0008016,GO:0010734,GO:0014704,GO:0016324,GO:0017080,GO:0030315,GO:0034220,GO:0042383,GO:0044325,GO:0086036,GO:1903278,GO:1903779,GO:2000649 chloride channel activity|plasma membrane|integral component of plasma membrane|sodium:potassium-exchanging ATPase complex|caveola|potassium ion transport|sodium ion transport|chloride transport|muscle contraction|regulation of heart contraction|negative regulation of protein glutathionylation|intercalated disc|apical plasma membrane|sodium channel regulator activity|T-tubule|ion transmembrane transport|sarcolemma|ion channel binding|regulation of cardiac muscle cell membrane potential|positive regulation of sodium ion export across plasma membrane|regulation of cardiac conduction|regulation of sodium ion transmembrane transporter activity hsa04024 cAMP signaling pathway FXYD2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:486,Genbank:NM_021603.3,HGNC:HGNC:4026,MIM:601814 FXYD domain containing ion transport regulator 2 GO:0001558,GO:0005215,GO:0005216,GO:0005391,GO:0005886,GO:0005887,GO:0005890,GO:0006810,GO:0016323,GO:0017080,GO:0034220,GO:0036376,GO:0042127,GO:0043231,GO:0070062,GO:0090662,GO:1903779,GO:1990573,GO:2000649 regulation of cell growth|transporter activity|ion channel activity|sodium:potassium-exchanging ATPase activity|plasma membrane|integral component of plasma membrane|sodium:potassium-exchanging ATPase complex|transport|basolateral plasma membrane|sodium channel regulator activity|ion transmembrane transport|sodium ion export across plasma membrane|regulation of cell proliferation|intracellular membrane-bounded organelle|extracellular exosome|ATP hydrolysis coupled transmembrane transport|regulation of cardiac conduction|potassium ion import across plasma membrane|regulation of sodium ion transmembrane transporter activity hsa04022,hsa04024,hsa04260,hsa04261,hsa04911,hsa04918,hsa04919,hsa04960,hsa04961,hsa04964,hsa04970,hsa04972,hsa04973,hsa04974,hsa04976,hsa04978 cGMP-PKG signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Insulin secretion|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Proximal tubule bicarbonate reclamation|Salivary secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Protein digestion and absorption|Bile secretion|Mineral absorption FXYD3 1.97929564580173 2.98845468642911 0.97013660517434 0.324628179767902 -1.62313985456153 0.555313687512503 1 0 0.0324621 0.0168838 0 GeneID:5349,Genbank:XM_011527032.3,HGNC:HGNC:4027,MIM:604996 FXYD domain containing ion transport regulator 3 FXYD5 894.837185844133 919.261625508965 870.412746179301 0.946860743477007 -0.078775833362781 0.599682509014894 1 14.6863 15.3949 15.4935 14.2441 GeneID:53827,Genbank:NM_001320912.1,HGNC:HGNC:4029,MIM:606669 FXYD domain containing ion transport regulator 5 FXYD6 1.99787069774731 2.05633815719933 1.93940323829528 0.943134392320322 -0.0844647319197664 1 1 0.0631208 0.0555076 0.0781086 0.0547819 GeneID:53826,Genbank:NM_001164831.2,HGNC:HGNC:4030,MIM:606683 FXYD domain containing ion transport regulator 6 GO:0005216,GO:0005886,GO:0005887,GO:0017080,GO:0034220,GO:1903779,GO:2000649 ion channel activity|plasma membrane|integral component of plasma membrane|sodium channel regulator activity|ion transmembrane transport|regulation of cardiac conduction|regulation of sodium ion transmembrane transporter activity FXYD7 2.2395348769875 2.05633815719933 2.42273159677566 1.17817762039457 0.236557054232323 1 1 0.210658 0.0896512 0.0955891 0.267459 GeneID:53822,Genbank:NM_022006.1,HGNC:HGNC:4034,MIM:606684 FXYD domain containing ion transport regulator 7 GO:0005216,GO:0005886,GO:0005887,GO:0017080,GO:0034220,GO:0051117,GO:1903779,GO:2000649 ion channel activity|plasma membrane|integral component of plasma membrane|sodium channel regulator activity|ion transmembrane transport|ATPase binding|regulation of cardiac conduction|regulation of sodium ion transmembrane transporter activity FYB1 1.21267075646793 0 2.42534151293585 Inf Inf 0.450088312527682 1 0 0 0.0198925 0 GeneID:2533,Genbank:XM_006714464.3,HGNC:HGNC:4036,MIM:602731 FYN binding protein 1 GO:0005102,GO:0005634,GO:0005829,GO:0005886,GO:0006468,GO:0006607,GO:0006955,GO:0007165,GO:0008289,GO:0015629,GO:0030054,GO:0032403,GO:0035556,GO:0050852,GO:0072659 receptor binding|nucleus|cytosol|plasma membrane|protein phosphorylation|NLS-bearing protein import into nucleus|immune response|signal transduction|lipid binding|actin cytoskeleton|cell junction|protein complex binding|intracellular signal transduction|T cell receptor signaling pathway|protein localization to plasma membrane hsa04015 Rap1 signaling pathway FYCO1 1193.00802439772 1170.48087326519 1215.53517553025 1.03849213028094 0.0544902834452619 0.727469298618911 1 3.83589 3.97657 4.62979 3.76474 GeneID:79443,Genbank:NM_024513.3,HGNC:HGNC:14673,MIM:607182 FYVE and coiled-coil domain containing 1 GO:0005524,GO:0005764,GO:0005770,GO:0005776,GO:0005794,GO:0006458,GO:0016020,GO:0043231,GO:0044183,GO:0046872,GO:0051082,GO:0061077,GO:0072383,GO:1901098 ATP binding|lysosome|late endosome|autophagosome|Golgi apparatus|'de novo' protein folding|membrane|intracellular membrane-bounded organelle|protein binding involved in protein folding|metal ion binding|unfolded protein binding|chaperone-mediated protein folding|plus-end-directed vesicle transport along microtubule|positive regulation of autophagosome maturation FYN 1294.81234449682 1248.17967811149 1341.44501088216 1.07472107934955 0.103962288045928 0.488447440439935 1 7.40141 8.18067 8.70414 8.09598 GeneID:2534,Genbank:NM_002037.5,HGNC:HGNC:4037,MIM:137025 FYN proto-oncogene, Src family tyrosine kinase GO:0000165,GO:0001764,GO:0002223,GO:0002250,GO:0004713,GO:0004715,GO:0004871,GO:0005088,GO:0005524,GO:0005634,GO:0005739,GO:0005768,GO:0005829,GO:0005884,GO:0005886,GO:0006468,GO:0006816,GO:0007169,GO:0007411,GO:0007417,GO:0007596,GO:0007612,GO:0007631,GO:0008360,GO:0010629,GO:0010976,GO:0014068,GO:0014069,GO:0015631,GO:0016477,GO:0018108,GO:0019221,GO:0030154,GO:0030168,GO:0030425,GO:0030900,GO:0031234,GO:0031295,GO:0031397,GO:0031802,GO:0035556,GO:0036120,GO:0038083,GO:0038096,GO:0042110,GO:0042127,GO:0042177,GO:0042531,GO:0042608,GO:0042609,GO:0042610,GO:0042802,GO:0042981,GO:0043123,GO:0043524,GO:0043548,GO:0044325,GO:0045087,GO:0045121,GO:0045471,GO:0046872,GO:0046875,GO:0046934,GO:0048010,GO:0048013,GO:0048156,GO:0048813,GO:0050690,GO:0050730,GO:0050798,GO:0050852,GO:0050900,GO:0050966,GO:0051428,GO:0051897,GO:0070851,GO:0071375,GO:0071560,GO:0090314,GO:0097062,GO:0097718,GO:1900182,GO:1901216,GO:1902951,GO:1904645,GO:1905232,GO:1905430,GO:1905664,GO:2001056,GO:2001240 MAPK cascade|neuron migration|stimulatory C-type lectin receptor signaling pathway|adaptive immune response|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signal transducer activity|Ras guanyl-nucleotide exchange factor activity|ATP binding|nucleus|mitochondrion|endosome|cytosol|actin filament|plasma membrane|protein phosphorylation|calcium ion transport|transmembrane receptor protein tyrosine kinase signaling pathway|axon guidance|central nervous system development|blood coagulation|learning|feeding behavior|regulation of cell shape|negative regulation of gene expression|positive regulation of neuron projection development|positive regulation of phosphatidylinositol 3-kinase signaling|postsynaptic density|tubulin binding|cell migration|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|cell differentiation|platelet activation|dendrite|forebrain development|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|negative regulation of protein ubiquitination|type 5 metabotropic glutamate receptor binding|intracellular signal transduction|cellular response to platelet-derived growth factor stimulus|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|T cell activation|regulation of cell proliferation|negative regulation of protein catabolic process|positive regulation of tyrosine phosphorylation of STAT protein|T cell receptor binding|CD4 receptor binding|CD8 receptor binding|identical protein binding|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of neuron apoptotic process|phosphatidylinositol 3-kinase binding|ion channel binding|innate immune response|membrane raft|response to ethanol|metal ion binding|ephrin receptor binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|tau protein binding|dendrite morphogenesis|regulation of defense response to virus by virus|regulation of peptidyl-tyrosine phosphorylation|activated T cell proliferation|T cell receptor signaling pathway|leukocyte migration|detection of mechanical stimulus involved in sensory perception of pain|peptide hormone receptor binding|positive regulation of protein kinase B signaling|growth factor receptor binding|cellular response to peptide hormone stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of protein targeting to membrane|dendritic spine maintenance|disordered domain specific binding|positive regulation of protein localization to nucleus|positive regulation of neuron death|negative regulation of dendritic spine maintenance|response to amyloid-beta|cellular response to L-glutamate|cellular response to glycine|regulation of calcium ion import across plasma membrane|positive regulation of cysteine-type endopeptidase activity|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa04071,hsa04072,hsa04360,hsa04380,hsa04510,hsa04520,hsa04611,hsa04650,hsa04660,hsa04664,hsa04725,hsa05020,hsa05130,hsa05162,hsa05416 Sphingolipid signaling pathway|Phospholipase D signaling pathway|Axon guidance|Osteoclast differentiation|Focal adhesion|Adherens junction|Platelet activation|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Cholinergic synapse|Prion diseases|Pathogenic Escherichia coli infection|Measles|Viral myocarditis FYTTD1 1745.70510441658 1896.35538309888 1595.05482573428 0.841115984878195 -0.249623341647014 0.192628765693732 1 20.8092 18.3135 18.5522 14.6818 GeneID:84248,Genbank:NM_001011537.2,HGNC:HGNC:25407,MIM:616933 forty-two-three domain containing 1 GO:0003723,GO:0003729,GO:0005654,GO:0006406,GO:0016607 RNA binding|mRNA binding|nucleoplasm|mRNA export from nucleus|nuclear speck FZD1 569.52573874479 554.096889470958 584.954588018623 1.05569007719413 0.0781863595821646 0.641180967862676 1 7.42812 7.00211 8.07172 7.40831 GeneID:8321,Genbank:NM_003505.1,HGNC:HGNC:4038,MIM:603408 frizzled class receptor 1 GO:0001934,GO:0003149,GO:0003150,GO:0003151,GO:0004930,GO:0005102,GO:0005109,GO:0005886,GO:0005925,GO:0007267,GO:0009986,GO:0010976,GO:0016021,GO:0017147,GO:0030165,GO:0030182,GO:0030514,GO:0030855,GO:0035414,GO:0035425,GO:0035567,GO:0042493,GO:0042813,GO:0044338,GO:0044339,GO:0045892,GO:0045893,GO:0051091,GO:0060022,GO:0060070,GO:0060071,GO:0090179,GO:0099054,GO:1903204,GO:1904886,GO:1904953,GO:1990909 positive regulation of protein phosphorylation|membranous septum morphogenesis|muscular septum morphogenesis|outflow tract morphogenesis|G-protein coupled receptor activity|receptor binding|frizzled binding|plasma membrane|focal adhesion|cell-cell signaling|cell surface|positive regulation of neuron projection development|integral component of membrane|Wnt-protein binding|PDZ domain binding|neuron differentiation|negative regulation of BMP signaling pathway|epithelial cell differentiation|negative regulation of catenin import into nucleus|autocrine signaling|non-canonical Wnt signaling pathway|response to drug|Wnt-activated receptor activity|canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt signaling pathway involved in osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of DNA binding transcription factor activity|hard palate development|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|planar cell polarity pathway involved in neural tube closure|presynapse assembly|negative regulation of oxidative stress-induced neuron death|beta-catenin destruction complex disassembly|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|Wnt signalosome hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD2 624.331466853483 664.178624466023 584.484309240943 0.880010719572386 -0.184406997296825 0.266931756664755 1 9.65843 9.515 8.89045 7.87878 GeneID:2535,Genbank:NM_001466.3,HGNC:HGNC:4040,MIM:600667 frizzled class receptor 2 GO:0003149,GO:0003150,GO:0003151,GO:0004930,GO:0005737,GO:0005886,GO:0005925,GO:0007223,GO:0007608,GO:0016021,GO:0017147,GO:0030165,GO:0030182,GO:0030669,GO:0030825,GO:0030855,GO:0035567,GO:0042813,GO:0045893,GO:0051091,GO:0060022,GO:0060070,GO:0060071,GO:0060119,GO:0090103,GO:0090179,GO:1904886 membranous septum morphogenesis|muscular septum morphogenesis|outflow tract morphogenesis|G-protein coupled receptor activity|cytoplasm|plasma membrane|focal adhesion|Wnt signaling pathway, calcium modulating pathway|sensory perception of smell|integral component of membrane|Wnt-protein binding|PDZ domain binding|neuron differentiation|clathrin-coated endocytic vesicle membrane|positive regulation of cGMP metabolic process|epithelial cell differentiation|non-canonical Wnt signaling pathway|Wnt-activated receptor activity|positive regulation of transcription, DNA-templated|positive regulation of DNA binding transcription factor activity|hard palate development|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|inner ear receptor cell development|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure|beta-catenin destruction complex disassembly hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD3 187.103336223265 184.214752857864 189.991919588666 1.03136104270248 0.0445494571832093 0.857755987010584 1 0.661245 0.485607 0.645308 0.494231 GeneID:7976,Genbank:NM_017412.3,HGNC:HGNC:4041,MIM:606143 frizzled class receptor 3 GO:0001736,GO:0001764,GO:0001843,GO:0001942,GO:0002052,GO:0004930,GO:0005737,GO:0005886,GO:0007223,GO:0009986,GO:0016021,GO:0016324,GO:0016328,GO:0017147,GO:0030165,GO:0030182,GO:0030424,GO:0030425,GO:0032433,GO:0033278,GO:0035567,GO:0036342,GO:0036514,GO:0036515,GO:0042472,GO:0042493,GO:0042813,GO:0043025,GO:0045976,GO:0048786,GO:0051602,GO:0060070,GO:0060071,GO:0061549,GO:0071679,GO:1900118,GO:1904693,GO:1904938 establishment of planar polarity|neuron migration|neural tube closure|hair follicle development|positive regulation of neuroblast proliferation|G-protein coupled receptor activity|cytoplasm|plasma membrane|Wnt signaling pathway, calcium modulating pathway|cell surface|integral component of membrane|apical plasma membrane|lateral plasma membrane|Wnt-protein binding|PDZ domain binding|neuron differentiation|axon|dendrite|filopodium tip|cell proliferation in midbrain|non-canonical Wnt signaling pathway|post-anal tail morphogenesis|dopaminergic neuron axon guidance|serotonergic neuron axon guidance|inner ear morphogenesis|response to drug|Wnt-activated receptor activity|neuronal cell body|negative regulation of mitotic cell cycle, embryonic|presynaptic active zone|response to electrical stimulus|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|sympathetic ganglion development|commissural neuron axon guidance|negative regulation of execution phase of apoptosis|midbrain morphogenesis|planar cell polarity pathway involved in axon guidance hsa04150,hsa04310,hsa04360,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05206,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD4 229.347128824651 213.436740531674 245.257517117628 1.1490876243082 0.200488815681898 0.423340940931316 1 1.18873 1.36092 1.80399 1.19679 GeneID:8322,Genbank:NM_012193.3,HGNC:HGNC:4042,MIM:604579 frizzled class receptor 4 GO:0001540,GO:0001570,GO:0004930,GO:0005886,GO:0005887,GO:0005911,GO:0007223,GO:0007605,GO:0009986,GO:0010812,GO:0016021,GO:0016055,GO:0017147,GO:0019955,GO:0030165,GO:0030182,GO:0030425,GO:0030665,GO:0030669,GO:0030947,GO:0031625,GO:0031987,GO:0034446,GO:0035426,GO:0035567,GO:0038023,GO:0042701,GO:0042803,GO:0042813,GO:0043507,GO:0045893,GO:0046982,GO:0051091,GO:0060070,GO:0060071,GO:0061024,GO:0061299,GO:0061301,GO:0061304,GO:0070062,GO:0071300,GO:1990830 amyloid-beta binding|vasculogenesis|G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|cell-cell junction|Wnt signaling pathway, calcium modulating pathway|sensory perception of sound|cell surface|negative regulation of cell-substrate adhesion|integral component of membrane|Wnt signaling pathway|Wnt-protein binding|cytokine binding|PDZ domain binding|neuron differentiation|dendrite|clathrin-coated vesicle membrane|clathrin-coated endocytic vesicle membrane|regulation of vascular endothelial growth factor receptor signaling pathway|ubiquitin protein ligase binding|locomotion involved in locomotory behavior|substrate adhesion-dependent cell spreading|extracellular matrix-cell signaling|non-canonical Wnt signaling pathway|signaling receptor activity|progesterone secretion|protein homodimerization activity|Wnt-activated receptor activity|positive regulation of JUN kinase activity|positive regulation of transcription, DNA-templated|protein heterodimerization activity|positive regulation of DNA binding transcription factor activity|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|membrane organization|retina vasculature morphogenesis in camera-type eye|cerebellum vasculature morphogenesis|retinal blood vessel morphogenesis|extracellular exosome|cellular response to retinoic acid|cellular response to leukemia inhibitory factor hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD5 299.970027180878 278.63382030051 321.306234061246 1.1531487229896 0.205578591118746 0.298397855654024 1 1.56328 1.43419 1.75999 1.69354 GeneID:7855,Genbank:XM_024453130.1,HGNC:HGNC:4043,MIM:601723 frizzled class receptor 5 GO:0000139,GO:0000578,GO:0001525,GO:0001540,GO:0002726,GO:0004930,GO:0005886,GO:0005887,GO:0005923,GO:0007223,GO:0007416,GO:0008285,GO:0008595,GO:0009986,GO:0016021,GO:0017147,GO:0019901,GO:0030182,GO:0030669,GO:0031077,GO:0031625,GO:0031901,GO:0032729,GO:0033077,GO:0035567,GO:0042813,GO:0043507,GO:0044332,GO:0045944,GO:0048469,GO:0048471,GO:0048596,GO:0050718,GO:0060061,GO:0060070,GO:0060071,GO:0060561,GO:0060670,GO:0060715,GO:0060716,GO:0060718,GO:0060828,GO:0071219,GO:1901382,GO:1903146,GO:1903955,GO:1904469,GO:1904886,GO:2000810 Golgi membrane|embryonic axis specification|angiogenesis|amyloid-beta binding|positive regulation of T cell cytokine production|G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|bicellular tight junction|Wnt signaling pathway, calcium modulating pathway|synapse assembly|negative regulation of cell proliferation|anterior/posterior axis specification, embryo|cell surface|integral component of membrane|Wnt-protein binding|protein kinase binding|neuron differentiation|clathrin-coated endocytic vesicle membrane|post-embryonic camera-type eye development|ubiquitin protein ligase binding|early endosome membrane|positive regulation of interferon-gamma production|T cell differentiation in thymus|non-canonical Wnt signaling pathway|Wnt-activated receptor activity|positive regulation of JUN kinase activity|Wnt signaling pathway involved in dorsal/ventral axis specification|positive regulation of transcription from RNA polymerase II promoter|cell maturation|perinuclear region of cytoplasm|embryonic camera-type eye morphogenesis|positive regulation of interleukin-1 beta secretion|Spemann organizer formation|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|apoptotic process involved in morphogenesis|branching involved in labyrinthine layer morphogenesis|syncytiotrophoblast cell differentiation involved in labyrinthine layer development|labyrinthine layer blood vessel development|chorionic trophoblast cell differentiation|regulation of canonical Wnt signaling pathway|cellular response to molecule of bacterial origin|regulation of chorionic trophoblast cell proliferation|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|positive regulation of tumor necrosis factor secretion|beta-catenin destruction complex disassembly|regulation of bicellular tight junction assembly hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD6 988.878828272285 1264.87727239505 712.880384149519 0.563596484581999 -0.827265481983485 2.13761697386396e-05 0.00847369839142897 14.9611 12.8909 7.86862 7.7349 GeneID:8323,Genbank:NM_001164615.1,HGNC:HGNC:4044,MIM:603409 frizzled class receptor 6 GO:0001843,GO:0001942,GO:0004930,GO:0005886,GO:0005887,GO:0007223,GO:0009986,GO:0016021,GO:0016324,GO:0016327,GO:0017147,GO:0030168,GO:0030659,GO:0031625,GO:0033278,GO:0035567,GO:0035880,GO:0042472,GO:0042813,GO:0043433,GO:0048105,GO:0060071,GO:0090090,GO:1904693 neural tube closure|hair follicle development|G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|Wnt signaling pathway, calcium modulating pathway|cell surface|integral component of membrane|apical plasma membrane|apicolateral plasma membrane|Wnt-protein binding|platelet activation|cytoplasmic vesicle membrane|ubiquitin protein ligase binding|cell proliferation in midbrain|non-canonical Wnt signaling pathway|embryonic nail plate morphogenesis|inner ear morphogenesis|Wnt-activated receptor activity|negative regulation of DNA binding transcription factor activity|establishment of body hair planar orientation|Wnt signaling pathway, planar cell polarity pathway|negative regulation of canonical Wnt signaling pathway|midbrain morphogenesis hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD7 541.43992771524 490.648372900997 592.231482529484 1.2070385131981 0.271471709161257 0.112233313877964 1 6.86218 6.70567 8.74483 7.89689 GeneID:8324,Genbank:NM_003507.1,HGNC:HGNC:4045,MIM:603410 frizzled class receptor 7 GO:0004930,GO:0005109,GO:0005546,GO:0005886,GO:0006355,GO:0010812,GO:0014834,GO:0016021,GO:0017147,GO:0019827,GO:0030165,GO:0030182,GO:0033077,GO:0034446,GO:0035412,GO:0038031,GO:0042327,GO:0042666,GO:0042813,GO:0045893,GO:0046330,GO:0048103,GO:0055038,GO:0060054,GO:0060070,GO:0060071,GO:0060231,GO:0071300,GO:2000726 G-protein coupled receptor activity|frizzled binding|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane|regulation of transcription, DNA-templated|negative regulation of cell-substrate adhesion|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|integral component of membrane|Wnt-protein binding|stem cell population maintenance|PDZ domain binding|neuron differentiation|T cell differentiation in thymus|substrate adhesion-dependent cell spreading|regulation of catenin import into nucleus|non-canonical Wnt signaling pathway via JNK cascade|positive regulation of phosphorylation|negative regulation of ectodermal cell fate specification|Wnt-activated receptor activity|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|somatic stem cell division|recycling endosome membrane|positive regulation of epithelial cell proliferation involved in wound healing|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|mesenchymal to epithelial transition|cellular response to retinoic acid|negative regulation of cardiac muscle cell differentiation hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZD8 300.023163129998 274.876945219121 325.169381040875 1.18296345581716 0.242405506538478 0.22724930429885 1 5.90553 5.65576 6.78859 7.16137 GeneID:8325,Genbank:NM_031866.2,HGNC:HGNC:4046,MIM:606146 frizzled class receptor 8 GO:0000122,GO:0001525,GO:0004930,GO:0005102,GO:0005794,GO:0016021,GO:0017147,GO:0030165,GO:0030182,GO:0031625,GO:0033077,GO:0035567,GO:0042813,GO:0043507,GO:0045944,GO:0060070,GO:1990851 negative regulation of transcription from RNA polymerase II promoter|angiogenesis|G-protein coupled receptor activity|receptor binding|Golgi apparatus|integral component of membrane|Wnt-protein binding|PDZ domain binding|neuron differentiation|ubiquitin protein ligase binding|T cell differentiation in thymus|non-canonical Wnt signaling pathway|Wnt-activated receptor activity|positive regulation of JUN kinase activity|positive regulation of transcription from RNA polymerase II promoter|canonical Wnt signaling pathway|Wnt-Frizzled-LRP5/6 complex hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer FZR1 2778.29275669034 2800.59459328657 2755.99092009411 0.984073498785089 -0.023162022846401 0.838857656363191 1 18.5563 19.877 19.1722 19.9421 GeneID:51343,Genbank:XM_005259573.5,HGNC:HGNC:24824,MIM:603619 fizzy and cell division cycle 20 related 1 GO:0005654,GO:0005829,GO:0006281,GO:0008284,GO:0010997,GO:0031145,GO:0031965,GO:0040020,GO:0042787,GO:0045732,GO:0051301,GO:0051436,GO:0051437,GO:0051439,GO:0070306,GO:0070979,GO:0072425,GO:0090344,GO:0097027,GO:1904668 nucleoplasm|cytosol|DNA repair|positive regulation of cell proliferation|anaphase-promoting complex binding|anaphase-promoting complex-dependent catabolic process|nuclear membrane|regulation of meiotic nuclear division|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|lens fiber cell differentiation|protein K11-linked ubiquitination|signal transduction involved in G2 DNA damage checkpoint|negative regulation of cell aging|ubiquitin-protein transferase activator activity|positive regulation of ubiquitin protein ligase activity hsa04110,hsa04120,hsa04914 Cell cycle|Ubiquitin mediated proteolysis|Progesterone-mediated oocyte maturation G2E3 88.6119456003509 89.4987361128559 87.7251550878458 0.980183172388338 -0.0288767158608581 0.956239536284742 1 0.67033 0.644514 0.720699 0.555508 GeneID:55632,Genbank:NM_017769.4,HGNC:HGNC:20338,MIM:611299 G2/M-phase specific E3 ubiquitin protein ligase GO:0004842,GO:0005730,GO:0005829,GO:0006915,GO:0007275,GO:0043231,GO:0046872 ubiquitin-protein transferase activity|nucleolus|cytosol|apoptotic process|multicellular organism development|intracellular membrane-bounded organelle|metal ion binding G3BP1 5836.0772342084 6186.09053542735 5486.06393298944 0.886838610196715 -0.173256512856761 0.196773008602618 1 80.6882 78.1247 73.1377 68.7156 GeneID:10146,Genbank:NM_005754.2,HGNC:HGNC:30292,MIM:608431 G3BP stress granule assembly factor 1 GO:0003677,GO:0003729,GO:0004386,GO:0004519,GO:0005524,GO:0005634,GO:0005829,GO:0005886,GO:0010494,GO:0090090 DNA binding|mRNA binding|helicase activity|endonuclease activity|ATP binding|nucleus|cytosol|plasma membrane|cytoplasmic stress granule|negative regulation of canonical Wnt signaling pathway G3BP2 4013.33414328898 3292.98542738131 4733.68285919665 1.43750495214339 0.5235669260886 8.97176363328445e-05 0.0217714797501036 23.6537 22.1875 36.7247 30.4497 GeneID:9908,Genbank:NM_203504.2,HGNC:HGNC:30291 G3BP stress granule assembly factor 2 GO:0003723,GO:0005829,GO:0034063,GO:0051028 RNA binding|cytosol|stress granule assembly|mRNA transport G6PC3 2033.47099491845 1937.53627452268 2129.40571531423 1.09902753476903 0.136227531671224 0.351701012259728 1 48.9094 55.1383 57.9961 59.755 GeneID:92579,Genbank:XM_017025335.2,HGNC:HGNC:24861,MIM:611045 glucose-6-phosphatase catalytic subunit 3 GO:0004346,GO:0005783,GO:0005789,GO:0006094,GO:0015760,GO:0016020,GO:0030176,GO:0051156 glucose-6-phosphatase activity|endoplasmic reticulum|endoplasmic reticulum membrane|gluconeogenesis|glucose-6-phosphate transport|membrane|integral component of endoplasmic reticulum membrane|glucose 6-phosphate metabolic process hsa00010,hsa00052,hsa00500,hsa04068,hsa04151,hsa04152,hsa04910,hsa04920,hsa04922,hsa04931,hsa04973 Glycolysis / Gluconeogenesis|Galactose metabolism|Starch and sucrose metabolism|FoxO signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Carbohydrate digestion and absorption G6PD 12841.8273816863 12964.9787744804 12718.6759888921 0.981002453619666 -0.0276713500631361 0.837068662374044 1 167.944 176.169 163.388 182.024 GeneID:2539,Genbank:NM_001042351.2,HGNC:HGNC:4057,MIM:305900 glucose-6-phosphate dehydrogenase hsa00030,hsa00480,hsa05230 Pentose phosphate pathway|Glutathione metabolism|Central carbon metabolism in cancer GAA 544.100210176897 513.451406074676 574.749014279117 1.11938346546377 0.162704342796538 0.356494618172821 1 5.18154 5.49328 5.95768 5.94132 GeneID:2548,Genbank:NM_000152.4,HGNC:HGNC:4065,MIM:606800 glucosidase alpha, acid hsa00052,hsa00500,hsa04142 Galactose metabolism|Starch and sucrose metabolism|Lysosome GAB1 170.06399193326 171.934558844461 168.193425022059 0.97824094325454 -0.0317382464515515 0.954685299789922 1 0.335221 0.262982 0.358247 0.240558 GeneID:2549,Genbank:NM_207123.2,HGNC:HGNC:4066,MIM:604439 GRB2 associated binding protein 1 hsa01521,hsa04012,hsa04014,hsa04072,hsa04722,hsa05100,hsa05205,hsa05211,hsa05225,hsa05226 EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Neurotrophin signaling pathway|Bacterial invasion of epithelial cells|Proteoglycans in cancer|Renal cell carcinoma|Hepatocellular carcinoma|Gastric cancer GAB2 553.588172408683 497.5093725284 609.666972288966 1.2254381644924 0.293297687769917 0.0856168912391434 0.964561165794104 2.18379 2.19829 2.83874 2.65934 GeneID:9846,Genbank:NM_080491.2,HGNC:HGNC:14458,MIM:606203 GRB2 associated binding protein 2 hsa04014,hsa04071,hsa04072,hsa04380,hsa04664,hsa04666,hsa05220 Ras signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Osteoclast differentiation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Chronic myeloid leukemia GAB3 22.7342974971385 29.4709107014878 15.9976842927892 0.54282965514132 -0.881428556598066 0.147277494408682 1 0.232303 0.17245 0.154554 0.0756097 GeneID:139716,Genbank:NM_080612.3,HGNC:HGNC:17515,MIM:300482 GRB2 associated binding protein 3 GO:0030225 macrophage differentiation GABARAP 7019.85039164673 6594.4661260836 7445.23465720986 1.12901249545602 0.175061453367495 0.288637941151495 1 326.173 350.499 363.983 409.611 GeneID:11337,Genbank:NM_007278.1,HGNC:HGNC:4067,MIM:605125 GABA type A receptor-associated protein GO:0000045,GO:0000139,GO:0000226,GO:0000421,GO:0000422,GO:0005764,GO:0005776,GO:0005790,GO:0005794,GO:0005829,GO:0005874,GO:0005875,GO:0005886,GO:0005930,GO:0006995,GO:0008017,GO:0008625,GO:0015031,GO:0015629,GO:0031410,GO:0031625,GO:0044297,GO:0048471,GO:0048487,GO:0050811,GO:0097225 autophagosome assembly|Golgi membrane|microtubule cytoskeleton organization|autophagosome membrane|autophagy of mitochondrion|lysosome|autophagosome|smooth endoplasmic reticulum|Golgi apparatus|cytosol|microtubule|microtubule associated complex|plasma membrane|axoneme|cellular response to nitrogen starvation|microtubule binding|extrinsic apoptotic signaling pathway via death domain receptors|protein transport|actin cytoskeleton|cytoplasmic vesicle|ubiquitin protein ligase binding|cell body|perinuclear region of cytoplasm|beta-tubulin binding|GABA receptor binding|sperm midpiece hsa04068,hsa04136,hsa04137,hsa04140,hsa04371,hsa04621,hsa04727,hsa05167 FoxO signaling pathway|Autophagy - other|Mitophagy - animal|Autophagy - animal|Apelin signaling pathway|NOD-like receptor signaling pathway|GABAergic synapse|Kaposi sarcoma-associated herpesvirus infection GABARAPL1 1494.18565575251 1385.27215814315 1603.09915336187 1.15724490955677 0.210694216573758 0.148266269614162 1 18.6917 19.4835 22.0613 22.5297 GeneID:23710,Genbank:XM_005253344.5,HGNC:HGNC:4068,MIM:607420 GABA type A receptor associated protein like 1 GO:0005739,GO:0005776,GO:0005783,GO:0005794,GO:0005874,GO:0006914,GO:0030659,GO:0030957,GO:0031625 mitochondrion|autophagosome|endoplasmic reticulum|Golgi apparatus|microtubule|autophagy|cytoplasmic vesicle membrane|Tat protein binding|ubiquitin protein ligase binding hsa04068,hsa04136,hsa04137,hsa04140,hsa04371,hsa04621,hsa04727,hsa05167 FoxO signaling pathway|Autophagy - other|Mitophagy - animal|Autophagy - animal|Apelin signaling pathway|NOD-like receptor signaling pathway|GABAergic synapse|Kaposi sarcoma-associated herpesvirus infection GABARAPL2 861.4482764281 905.39453042925 817.50202242695 0.902923526652376 -0.147324291446305 0.353122294675087 1 49.5488 48.7401 41.3574 46.2441 GeneID:11345,Genbank:NM_007285.6,HGNC:HGNC:13291,MIM:607452 GABA type A receptor associated protein like 2 GO:0000045,GO:0000139,GO:0000149,GO:0000421,GO:0000422,GO:0005776,GO:0005829,GO:0006891,GO:0006995,GO:0015031,GO:0031410,GO:0032781,GO:0051117 autophagosome assembly|Golgi membrane|SNARE binding|autophagosome membrane|autophagy of mitochondrion|autophagosome|cytosol|intra-Golgi vesicle-mediated transport|cellular response to nitrogen starvation|protein transport|cytoplasmic vesicle|positive regulation of ATPase activity|ATPase binding hsa04068,hsa04136,hsa04137,hsa04140,hsa04371,hsa04621,hsa04727,hsa05167 FoxO signaling pathway|Autophagy - other|Mitophagy - animal|Autophagy - animal|Apelin signaling pathway|NOD-like receptor signaling pathway|GABAergic synapse|Kaposi sarcoma-associated herpesvirus infection GABBR1 247.652153430658 256.840355896069 238.463950965247 0.928452034468221 -0.10710071506839 0.636695365863407 1 1.47846 1.0831 1.35709 1.07675 GeneID:2550,Genbank:NM_021904.3,HGNC:HGNC:4070,MIM:603540 gamma-aminobutyric acid type B receptor subunit 1 GO:0004965,GO:0005576,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007193,GO:0007194,GO:0007214,GO:0030054,GO:0030425,GO:0038039,GO:0042734,GO:0045211 G-protein coupled GABA receptor activity|extracellular region|cytoplasm|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|gamma-aminobutyric acid signaling pathway|cell junction|dendrite|G-protein coupled receptor heterodimeric complex|presynaptic membrane|postsynaptic membrane hsa04024,hsa04080,hsa04727,hsa04742,hsa04915,hsa05032 cAMP signaling pathway|Neuroactive ligand-receptor interaction|GABAergic synapse|Taste transduction|Estrogen signaling pathway|Morphine addiction GABBR2 3.31322868058701 3.71865746181119 2.90779989936283 0.781948842888738 -0.35485386910013 0.957126709579746 1 0.023864 0.00539309 0.0168729 0.015732 GeneID:9568,Genbank:NM_005458.7,HGNC:HGNC:4507,MIM:607340 gamma-aminobutyric acid type B receptor subunit 2 GO:0004965,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007194,GO:0007214,GO:0007268,GO:0030054,GO:0038039,GO:0043005,GO:0045211,GO:0046982,GO:1902710 G-protein coupled GABA receptor activity|cytoplasm|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|cell junction|G-protein coupled receptor heterodimeric complex|neuron projection|postsynaptic membrane|protein heterodimerization activity|GABA receptor complex hsa04024,hsa04080,hsa04727,hsa04742,hsa04915,hsa05032 cAMP signaling pathway|Neuroactive ligand-receptor interaction|GABAergic synapse|Taste transduction|Estrogen signaling pathway|Morphine addiction GABPA 167.87528899934 167.57194250153 168.178635497151 1.00362049270638 0.00521383423361108 0.962445143834714 1 1.34816 0.958664 1.39731 1.04761 GeneID:2551,Genbank:NM_001197297.1,HGNC:HGNC:4071,MIM:600609 GA binding protein transcription factor alpha subunit GO:0000122,GO:0000790,GO:0000978,GO:0001077,GO:0001228,GO:0001701,GO:0003677,GO:0003682,GO:0003700,GO:0003713,GO:0005634,GO:0005654,GO:0006366,GO:0007005,GO:0010628,GO:0030154,GO:0033613,GO:0044212,GO:0045653,GO:0045944,GO:0046982,GO:1903351 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|in utero embryonic development|DNA binding|chromatin binding|DNA binding transcription factor activity|transcription coactivator activity|nucleus|nucleoplasm|transcription from RNA polymerase II promoter|mitochondrion organization|positive regulation of gene expression|cell differentiation|activating transcription factor binding|transcription regulatory region DNA binding|negative regulation of megakaryocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|cellular response to dopamine GABPB1 463.458285599276 497.527972837761 429.388598360791 0.86304413380353 -0.212493757972748 0.24237350123889 1 2.35707 2.01442 1.95884 1.92975 GeneID:2553,Genbank:NM_001320915.1,HGNC:HGNC:4074,MIM:600610 GA binding protein transcription factor beta subunit 1 GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0007005,GO:0036464,GO:0044212,GO:0045944,GO:0046982 DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|mitochondrion organization|cytoplasmic ribonucleoprotein granule|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity GABPB2 102.557149597202 102.864934134652 102.249365059752 0.994015753958549 -0.00865937793102283 1 1 0.861367 0.751863 0.757731 0.841423 GeneID:126626,Genbank:XM_017000247.2,HGNC:HGNC:28441 GA binding protein transcription factor beta subunit 2 GO:0003700,GO:0005634,GO:0006351,GO:0042803,GO:0044212,GO:0045944,GO:0046982 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|protein homodimerization activity|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity GABRA2 20.6503210207332 15.6146412777348 25.6860007637317 1.64499461158662 0.718082858215839 0.244667676535497 1 0.079191 0.0416854 0.123179 0.100329 GeneID:2555,Genbank:XM_024453968.1,HGNC:HGNC:4076,MIM:137140 gamma-aminobutyric acid type A receptor alpha2 subunit GO:0004890,GO:0005230,GO:0005254,GO:0007214,GO:0030054,GO:0030659,GO:0034707,GO:0045211 GABA-A receptor activity|extracellular ligand-gated ion channel activity|chloride channel activity|gamma-aminobutyric acid signaling pathway|cell junction|cytoplasmic vesicle membrane|chloride channel complex|postsynaptic membrane hsa04080,hsa04723,hsa04727,hsa04742,hsa05032,hsa05033 Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Taste transduction|Morphine addiction|Nicotine addiction GABRA3 450.835844296297 454.854560248748 446.817128343847 0.982329666211315 -0.0257208259551635 0.897533834035322 1 3.81241 3.78518 3.72846 3.85945 GeneID:2556,Genbank:XM_006724811.3,HGNC:HGNC:4077,MIM:305660 gamma-aminobutyric acid type A receptor alpha3 subunit hsa04080,hsa04723,hsa04727,hsa04742,hsa05032,hsa05033 Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Taste transduction|Morphine addiction|Nicotine addiction GABRB1 9.68411038419904 7.73528122683997 11.6329395415581 1.50388062184397 0.588690050320619 0.552901400730879 1 0.0214701 0.0051688 0.0310193 0.0240928 GeneID:2560,Genbank:XM_024453977.1,HGNC:HGNC:4081,MIM:137190 gamma-aminobutyric acid type A receptor beta1 subunit hsa04080,hsa04723,hsa04726,hsa04727,hsa05032,hsa05033 Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|Serotonergic synapse|GABAergic synapse|Morphine addiction|Nicotine addiction GABRB3 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00625561 0 GeneID:2562,Genbank:NM_021912.4,HGNC:HGNC:4083,MIM:137192 gamma-aminobutyric acid type A receptor beta3 subunit hsa04080,hsa04723,hsa04726,hsa04727,hsa05032,hsa05033 Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|Serotonergic synapse|GABAergic synapse|Morphine addiction|Nicotine addiction GABRE 322.1224478784 326.78527920617 317.459616550631 0.971462415081263 -0.0417699144393668 0.829407324436726 1 1.38884 1.40871 1.54736 1.18006 GeneID:2564,Genbank:XM_024452360.1,HGNC:HGNC:4085,MIM:300093 gamma-aminobutyric acid type A receptor epsilon subunit GO:0004890,GO:0022851,GO:0030054,GO:0034707,GO:0045211,GO:1902711,GO:2001226 GABA-A receptor activity|GABA-gated chloride ion channel activity|cell junction|chloride channel complex|postsynaptic membrane|GABA-A receptor complex|negative regulation of chloride transport hsa04080,hsa04723,hsa04727,hsa05032,hsa05033 Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Morphine addiction|Nicotine addiction GABRG3 1.51280239516014 2.05633815719933 0.969266633120943 0.471355661872779 -1.08511203720016 0.811646606184739 1 0.00306813 0.00291018 0.00293619 0 GeneID:2567,Genbank:NM_033223.4,HGNC:HGNC:4088,MIM:600233 gamma-aminobutyric acid type A receptor gamma3 subunit hsa04080,hsa04723,hsa04727,hsa05032,hsa05033 Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Morphine addiction|Nicotine addiction GABRP 2.93749187603238 5.39078542153098 0.484198330533773 0.0898196260233004 -3.47682547450931 0.404305836203503 1 0 0.108507 0 0 GeneID:2568,Genbank:XM_024446012.1,HGNC:HGNC:4089,MIM:602729 gamma-aminobutyric acid type A receptor pi subunit GO:0004890,GO:0005230,GO:0005254,GO:0030054,GO:0034707,GO:0045211,GO:1902711 GABA-A receptor activity|extracellular ligand-gated ion channel activity|chloride channel activity|cell junction|chloride channel complex|postsynaptic membrane|GABA-A receptor complex hsa04080,hsa04723,hsa04727,hsa05032,hsa05033 Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Morphine addiction|Nicotine addiction GABRQ 147.078731622327 144.405333441442 149.752129803212 1.03702630806181 0.0524524939861155 0.874436758819834 1 1.28975 1.63837 1.57233 1.51811 GeneID:55879,Genbank:XM_011531184.3,HGNC:HGNC:14454,MIM:300349 gamma-aminobutyric acid type A receptor theta subunit GO:0004888,GO:0004890,GO:0005230,GO:0005254,GO:0005326,GO:0005886,GO:0005887,GO:0007165,GO:0030054,GO:0034707,GO:0043235,GO:0045211,GO:1902711 transmembrane signaling receptor activity|GABA-A receptor activity|extracellular ligand-gated ion channel activity|chloride channel activity|neurotransmitter transporter activity|plasma membrane|integral component of plasma membrane|signal transduction|cell junction|chloride channel complex|receptor complex|postsynaptic membrane|GABA-A receptor complex hsa04080,hsa04723,hsa04727,hsa05032,hsa05033 Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Morphine addiction|Nicotine addiction GABRR1 1.4627095568168 1.47021420587209 1.45520490776151 0.989791080748215 -0.0148040531050535 1 1 0 0.0300495 0.0307685 0 GeneID:2569,Genbank:NM_001267582.1,HGNC:HGNC:4090,MIM:137161 gamma-aminobutyric acid type A receptor rho1 subunit GO:0004890,GO:0005230,GO:0005254,GO:0005886,GO:0005887,GO:0006810,GO:0007214,GO:0007268,GO:0030054,GO:0034707,GO:0045211,GO:1902711 GABA-A receptor activity|extracellular ligand-gated ion channel activity|chloride channel activity|plasma membrane|integral component of plasma membrane|transport|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|cell junction|chloride channel complex|postsynaptic membrane|GABA-A receptor complex hsa04080,hsa04723,hsa04727,hsa05032,hsa05033 Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Morphine addiction|Nicotine addiction GABRR2 13.1210170271671 16.5467578069645 9.69527624736962 0.585932081709014 -0.771194650479356 0.350955343648882 1 0.0863548 0.0531884 0.0454881 0.0297679 GeneID:2570,Genbank:NM_002043.4,HGNC:HGNC:4091,MIM:137162 gamma-aminobutyric acid type A receptor rho2 subunit GO:0004890,GO:0005230,GO:0005254,GO:0005886,GO:0005887,GO:0006810,GO:0007165,GO:0007214,GO:0007268,GO:0007601,GO:0019904,GO:0030054,GO:0034707,GO:0045211,GO:1902711 GABA-A receptor activity|extracellular ligand-gated ion channel activity|chloride channel activity|plasma membrane|integral component of plasma membrane|transport|signal transduction|gamma-aminobutyric acid signaling pathway|chemical synaptic transmission|visual perception|protein domain specific binding|cell junction|chloride channel complex|postsynaptic membrane|GABA-A receptor complex hsa04080,hsa04723,hsa04727,hsa05032,hsa05033 Neuroactive ligand-receptor interaction|Retrograde endocannabinoid signaling|GABAergic synapse|Morphine addiction|Nicotine addiction GAD1 125.200942516969 134.594096747186 115.807788286751 0.860422493151967 -0.216882854721193 0.435744606276732 1 0.99396 0.850578 0.605972 0.792658 GeneID:2571,Genbank:XM_011510922.1,HGNC:HGNC:4092,MIM:605363 glutamate decarboxylase 1 GO:0004351,GO:0005739,GO:0005938,GO:0019752,GO:0030170,GO:0030424,GO:0035176,GO:0035641,GO:0042136,GO:0043679,GO:0048786,GO:0060077 glutamate decarboxylase activity|mitochondrion|cell cortex|carboxylic acid metabolic process|pyridoxal phosphate binding|axon|social behavior|locomotory exploration behavior|neurotransmitter biosynthetic process|axon terminus|presynaptic active zone|inhibitory synapse hsa00250,hsa00410,hsa00430,hsa00650,hsa04727,hsa04940 Alanine, aspartate and glutamate metabolism|beta-Alanine metabolism|Taurine and hypotaurine metabolism|Butanoate metabolism|GABAergic synapse|Type I diabetes mellitus GADD45A 1070.39714658522 1194.81093857368 945.983354596759 0.79174313195194 -0.336895647369424 0.025045945677821 0.631315976879816 39.1567 41.7142 33.0195 32.0731 GeneID:1647,Genbank:NM_001924.3,HGNC:HGNC:4095,MIM:126335 growth arrest and DNA damage inducible alpha GO:0000185,GO:0000979,GO:0005634,GO:0005737,GO:0006469,GO:0007098,GO:0016607,GO:0019900,GO:0042770,GO:0042803,GO:0043065,GO:0046330,GO:0046982,GO:0047485,GO:0051726,GO:0071260,GO:0071479,GO:0071850,GO:1900745,GO:2000379 activation of MAPKKK activity|RNA polymerase II core promoter sequence-specific DNA binding|nucleus|cytoplasm|negative regulation of protein kinase activity|centrosome cycle|nuclear speck|kinase binding|signal transduction in response to DNA damage|protein homodimerization activity|positive regulation of apoptotic process|positive regulation of JNK cascade|protein heterodimerization activity|protein N-terminus binding|regulation of cell cycle|cellular response to mechanical stimulus|cellular response to ionizing radiation|mitotic cell cycle arrest|positive regulation of p38MAPK cascade|positive regulation of reactive oxygen species metabolic process hsa04010,hsa04068,hsa04110,hsa04115,hsa04210,hsa04218,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 MAPK signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Apoptosis|Cellular senescence|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer GADD45B 1405.28354078782 1567.59528597894 1242.97179559669 0.792916262707743 -0.334759579216732 0.0206223713986395 0.586657016555258 30.8982 32.2446 23.4442 27.0018 GeneID:4616,Genbank:NM_015675.3,HGNC:HGNC:4096,MIM:604948 growth arrest and DNA damage inducible beta hsa04010,hsa04064,hsa04068,hsa04110,hsa04115,hsa04210,hsa04218,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 MAPK signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Apoptosis|Cellular senescence|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer GADD45G 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0.0716019 0 0.0656288 0.0612994 GeneID:10912,Genbank:XM_011518163.2,HGNC:HGNC:4097,MIM:604949 growth arrest and DNA damage inducible gamma hsa04010,hsa04068,hsa04110,hsa04115,hsa04210,hsa04218,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 MAPK signaling pathway|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Apoptosis|Cellular senescence|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer GADD45GIP1 1693.72370620677 1799.96353174417 1587.48388066937 0.88195335776114 -0.181225734236089 0.389305335470272 1 126.491 140.546 110.911 127.974 GeneID:90480,Genbank:NM_052850.3,HGNC:HGNC:29996,MIM:605162 GADD45G interacting protein 1 GAK 2422.83459658625 2155.06505705768 2690.60413611482 1.24850251146864 0.320198723372421 0.0218211685305923 0.600929980812952 11.1827 11.5307 13.7584 14.1707 GeneID:2580,Genbank:NM_001318134.1,HGNC:HGNC:4113,MIM:602052 cyclin G associated kinase GO:0004674,GO:0005524,GO:0005794,GO:0005829,GO:0005925,GO:0006898,GO:0007029,GO:0007030,GO:0007049,GO:0010977,GO:0016020,GO:0016191,GO:0030332,GO:0031982,GO:0043231,GO:0045202,GO:0048471,GO:0051085,GO:0051087,GO:0061024,GO:0072318,GO:0072583,GO:0072600,GO:0072659,GO:0090160,GO:1905224 protein serine/threonine kinase activity|ATP binding|Golgi apparatus|cytosol|focal adhesion|receptor-mediated endocytosis|endoplasmic reticulum organization|Golgi organization|cell cycle|negative regulation of neuron projection development|membrane|synaptic vesicle uncoating|cyclin binding|vesicle|intracellular membrane-bounded organelle|synapse|perinuclear region of cytoplasm|chaperone cofactor-dependent protein refolding|chaperone binding|membrane organization|clathrin coat disassembly|clathrin-dependent endocytosis|establishment of protein localization to Golgi|protein localization to plasma membrane|Golgi to lysosome transport|clathrin-coated pit assembly GAL3ST1 1.21680388378472 0.980142803914724 1.45346496365472 1.48291142663041 0.568432429095832 1 1 0 0 0.00814813 0.0152409 GeneID:9514,Genbank:XM_011530524.1,HGNC:HGNC:24240,MIM:602300 galactose-3-O-sulfotransferase 1 GO:0000139,GO:0001733,GO:0005887,GO:0006487,GO:0006682,GO:0007283,GO:0008146,GO:0016020,GO:0042552 Golgi membrane|galactosylceramide sulfotransferase activity|integral component of plasma membrane|protein N-linked glycosylation|galactosylceramide biosynthetic process|spermatogenesis|sulfotransferase activity|membrane|myelination hsa00565,hsa00600 Ether lipid metabolism|Sphingolipid metabolism GAL3ST2 2.70265660589059 2.49838328447175 2.90692992730943 1.16352440611372 0.218501473063789 1 1 0 0.170357 0.0465081 0.130016 GeneID:64090,Genbank:NM_022134.2,HGNC:HGNC:24869,MIM:608237 galactose-3-O-sulfotransferase 2 GO:0001733,GO:0008146,GO:0009247,GO:0016020,GO:0016021,GO:0032580 galactosylceramide sulfotransferase activity|sulfotransferase activity|glycolipid biosynthetic process|membrane|integral component of membrane|Golgi cisterna membrane GAL3ST4 8.15142797901323 6.61105959887042 9.69179635915603 1.46599742661706 0.551882570995553 0.637620459725894 1 0.102578 0.143532 0.171353 0.160254 GeneID:79690,Genbank:NM_024637.4,HGNC:HGNC:24145,MIM:608235 galactose-3-O-sulfotransferase 4 GO:0001733,GO:0006790,GO:0007267,GO:0009100,GO:0009247,GO:0009311,GO:0016020,GO:0016021,GO:0030166,GO:0032580,GO:0050656,GO:0050694,GO:0050698,GO:0070062 galactosylceramide sulfotransferase activity|sulfur compound metabolic process|cell-cell signaling|glycoprotein metabolic process|glycolipid biosynthetic process|oligosaccharide metabolic process|membrane|integral component of membrane|proteoglycan biosynthetic process|Golgi cisterna membrane|3'-phosphoadenosine 5'-phosphosulfate binding|galactose 3-O-sulfotransferase activity|proteoglycan sulfotransferase activity|extracellular exosome GALE 1508.39633010848 1701.63268474012 1315.15997547684 0.772881237690671 -0.371681350799433 0.027479345735229 0.664817524615449 29.094 31.4497 22.9579 25.8375 GeneID:2582,Genbank:NM_001008216.1,HGNC:HGNC:4116,MIM:606953 UDP-galactose-4-epimerase hsa00052,hsa00520 Galactose metabolism|Amino sugar and nucleotide sugar metabolism GALK1 448.98339251645 458.92901894357 439.037766089331 0.956657234489056 -0.0639259880253638 0.724251803051523 1 17.5982 16.7834 15.4687 18.2441 GeneID:2584,Genbank:NM_000154.1,HGNC:HGNC:4118,MIM:604313 galactokinase 1 hsa00052,hsa00520 Galactose metabolism|Amino sugar and nucleotide sugar metabolism GALK2 413.561330001296 425.854103639002 401.26855636359 0.942267675559954 -0.0857911419003429 0.659012380584778 1 1.88545 1.8943 1.84095 1.67428 GeneID:2585,Genbank:NM_001352048.1,HGNC:HGNC:4119,MIM:137028 galactokinase 2 GO:0004335,GO:0005524,GO:0005534,GO:0005737,GO:0005975,GO:0006012,GO:0033858 galactokinase activity|ATP binding|galactose binding|cytoplasm|carbohydrate metabolic process|galactose metabolic process|N-acetylgalactosamine kinase activity GALM 0.97720626820293 1.47021420587209 0.484198330533773 0.329338628752101 -1.60235635659317 0.793508671995383 1 0 0 0 0.0129935 GeneID:130589,Genbank:NM_138801.2,HGNC:HGNC:24063,MIM:137030 galactose mutarotase GO:0004034,GO:0005737,GO:0006006,GO:0006012,GO:0030246,GO:0033499,GO:0070062 aldose 1-epimerase activity|cytoplasm|glucose metabolic process|galactose metabolic process|carbohydrate binding|galactose catabolic process via UDP-galactose|extracellular exosome hsa00010,hsa00052 Glycolysis / Gluconeogenesis|Galactose metabolism GALNS 1095.82901146907 1069.74972952774 1121.9082934104 1.04875772570252 0.0686814383567821 0.672867561424906 1 4.52447 4.83484 5.2498 4.99546 GeneID:2588,Genbank:NM_001323543.1,HGNC:HGNC:4122,MIM:612222 galactosamine (N-acetyl)-6-sulfatase GO:0003943,GO:0005576,GO:0008484,GO:0035578,GO:0042340,GO:0043202,GO:0043312,GO:0043890,GO:0046872,GO:0070062 N-acetylgalactosamine-4-sulfatase activity|extracellular region|sulfuric ester hydrolase activity|azurophil granule lumen|keratan sulfate catabolic process|lysosomal lumen|neutrophil degranulation|N-acetylgalactosamine-6-sulfatase activity|metal ion binding|extracellular exosome hsa00531,hsa04142 Glycosaminoglycan degradation|Lysosome GALNT1 270.795191802731 276.951883685682 264.63849991978 0.955539628032005 -0.0656123891574311 0.819929296444389 1 3.20478 2.60223 3.29485 2.30173 GeneID:2589,Genbank:NM_020474.3,HGNC:HGNC:4123,MIM:602273 polypeptide N-acetylgalactosaminyltransferase 1 hsa00512 Mucin type O-glycan biosynthesis GALNT10 4599.11874501857 4114.18779722668 5084.04969281046 1.23573593218996 0.305370482706447 0.0217950101071938 0.600929980812952 25.6316 24.8973 34.5965 29.0624 GeneID:55568,Genbank:NM_198321.3,HGNC:HGNC:19873,MIM:608043 polypeptide N-acetylgalactosaminyltransferase 10 hsa00512 Mucin type O-glycan biosynthesis GALNT11 1244.13699660224 1163.80115308056 1324.47284012393 1.13805767988635 0.186573679241329 0.201897660656193 1 8.88073 8.32171 9.88602 10.0639 GeneID:63917,Genbank:XM_006716082.3,HGNC:HGNC:19875,MIM:615130 polypeptide N-acetylgalactosaminyltransferase 11 hsa00512 Mucin type O-glycan biosynthesis GALNT12 28.9918469628563 35.6879514477707 22.2957424779419 0.624741448400917 -0.678668846368944 0.210003683491568 1 0.27879 0.225169 0.179831 0.119743 GeneID:79695,Genbank:NM_024642.4,HGNC:HGNC:19877,MIM:610290 polypeptide N-acetylgalactosaminyltransferase 12 hsa00512 Mucin type O-glycan biosynthesis GALNT13 123.950287988091 119.939980963151 127.960595013032 1.06687189697275 0.0933869571395706 0.761866148612676 1 0.781325 0.565125 0.90785 0.588341 GeneID:114805,Genbank:NM_052917.3,HGNC:HGNC:23242,MIM:608369 polypeptide N-acetylgalactosaminyltransferase 13 hsa00512 Mucin type O-glycan biosynthesis GALNT15 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0 0 0.0044152 0.00205969 GeneID:117248,Genbank:NM_001319051.1,HGNC:HGNC:21531,MIM:615131 polypeptide N-acetylgalactosaminyltransferase 15 hsa00512 Mucin type O-glycan biosynthesis GALNT16 17.9621399551103 15.0863522562004 20.8379276540202 1.38124361012821 0.465967790362777 0.536152610496495 1 0.0543311 0.138535 0.130898 0.156185 GeneID:57452,Genbank:XM_017021498.1,HGNC:HGNC:23233,MIM:615132 polypeptide N-acetylgalactosaminyltransferase 16 hsa00512 Mucin type O-glycan biosynthesis GALNT17 1661.65675695583 1425.96668481497 1897.3468290967 1.33056883397167 0.412043146858314 0.00417516703265995 0.253293466648037 6.3775 6.64674 9.00094 8.61441 GeneID:64409,Genbank:XM_011516467.3,HGNC:HGNC:16347,MIM:615137 polypeptide N-acetylgalactosaminyltransferase 17 hsa00512 Mucin type O-glycan biosynthesis GALNT18 8.15556110633002 7.59120240278514 8.7199198098749 1.14868756584275 0.199986449416929 0.922342920291036 1 0.01296 0.0198468 0.0074948 0.0255884 GeneID:374378,Genbank:NM_198516.2,HGNC:HGNC:30488,MIM:615136 polypeptide N-acetylgalactosaminyltransferase 18 GO:0000139,GO:0004653,GO:0006493,GO:0016021,GO:0030246,GO:0046872 Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|protein O-linked glycosylation|integral component of membrane|carbohydrate binding|metal ion binding hsa00512 Mucin type O-glycan biosynthesis GALNT2 4072.69619386484 3474.43732462022 4670.95506310946 1.34437741328951 0.426938209429967 0.00151624588218301 0.136428056455298 21.7934 21.9584 30.4956 28.1227 GeneID:2590,Genbank:NM_001291866.1,HGNC:HGNC:4124,MIM:602274 polypeptide N-acetylgalactosaminyltransferase 2 hsa00512 Mucin type O-glycan biosynthesis GALNT3 1.73088842308455 2.00831188251439 1.45346496365472 0.723724724386428 -0.466487036088226 0.969067157519303 1 0 0.02255 0.00751887 0.00699788 GeneID:2591,Genbank:XM_017003770.1,HGNC:HGNC:4125,MIM:601756 polypeptide N-acetylgalactosaminyltransferase 3 hsa00512 Mucin type O-glycan biosynthesis GALNT4 3.24118926855959 3.57457863775636 2.90779989936283 0.813466479279346 -0.297845197267169 0.956861882653057 1 0.517229 0.579983 0.388225 0.435839 GeneID:8693,Genbank:NM_003774.4,HGNC:HGNC:4126,MIM:603565 polypeptide N-acetylgalactosaminyltransferase 4 hsa00512 Mucin type O-glycan biosynthesis GALNT5 200.482911070617 184.310805407234 216.655016733999 1.17548733106179 0.233258990277352 0.456631573444389 1 0.744579 0.45851 0.785684 0.593822 GeneID:11227,Genbank:NM_001329868.1,HGNC:HGNC:4127,MIM:615129 polypeptide N-acetylgalactosaminyltransferase 5 hsa00512 Mucin type O-glycan biosynthesis GALNT6 1.26733170815476 1.56626675524197 0.968396661067546 0.618283352964316 -0.693659932761692 0.974554396098478 1 0.0139939 0 0 0.012288 GeneID:11226,Genbank:XM_005268607.1,HGNC:HGNC:4128,MIM:605148 polypeptide N-acetylgalactosaminyltransferase 6 hsa00512 Mucin type O-glycan biosynthesis GALNT7 949.939724218283 1058.4063756944 841.473072742163 0.795037796508062 -0.330904646391553 0.395242816944329 1 6.0211 4.57916 5.29085 3.18856 GeneID:51809,Genbank:NM_017423.2,HGNC:HGNC:4129,MIM:605005 polypeptide N-acetylgalactosaminyltransferase 7 hsa00512 Mucin type O-glycan biosynthesis GALNT8 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0174989 0 0 0 GeneID:26290,Genbank:NM_017417.1,HGNC:HGNC:4130,MIM:606250 polypeptide N-acetylgalactosaminyltransferase 8 hsa00512 Mucin type O-glycan biosynthesis GALNTL6 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0129716 GeneID:442117,Genbank:XM_017008243.2,HGNC:HGNC:33844,MIM:615138 polypeptide N-acetylgalactosaminyltransferase like 6 GO:0000139,GO:0004653,GO:0016021,GO:0018243,GO:0030246,GO:0046872 Golgi membrane|polypeptide N-acetylgalactosaminyltransferase activity|integral component of membrane|protein O-linked glycosylation via threonine|carbohydrate binding|metal ion binding hsa00512 Mucin type O-glycan biosynthesis GALR2 8.99052726640114 9.74359310935436 8.23746142344792 0.845423380368739 -0.242254083919633 0.856991229724695 1 0.0375397 0.102612 0.0708403 0.0824869 GeneID:8811,Genbank:XM_011525427.3,HGNC:HGNC:4133,MIM:603691 galanin receptor 2 GO:0004966,GO:0005622,GO:0005886,GO:0005887,GO:0006936,GO:0007166,GO:0007186,GO:0007188,GO:0007189,GO:0007194,GO:0007200,GO:0007204,GO:0007268,GO:0007275,GO:0007586,GO:0007611,GO:0007631,GO:0016021,GO:0017046,GO:0031175,GO:0042923,GO:0043647,GO:0045944,GO:0046488,GO:1902608 galanin receptor activity|intracellular|plasma membrane|integral component of plasma membrane|muscle contraction|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|multicellular organism development|digestion|learning or memory|feeding behavior|integral component of membrane|peptide hormone binding|neuron projection development|neuropeptide binding|inositol phosphate metabolic process|positive regulation of transcription from RNA polymerase II promoter|phosphatidylinositol metabolic process|positive regulation of large conductance calcium-activated potassium channel activity hsa04080 Neuroactive ligand-receptor interaction GALR3 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0 0 GeneID:8484,Genbank:NM_003614.1,HGNC:HGNC:4134,MIM:603692 galanin receptor 3 GO:0004966,GO:0005886,GO:0005887,GO:0007186,GO:0007188,GO:0007194,GO:0007200,GO:0007218,GO:0007268,GO:0007611,GO:0007631,GO:0016021,GO:0017046,GO:0045944,GO:0097730 galanin receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|phospholipase C-activating G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|learning or memory|feeding behavior|integral component of membrane|peptide hormone binding|positive regulation of transcription from RNA polymerase II promoter|non-motile cilium hsa04080 Neuroactive ligand-receptor interaction GALT 1.21723886981142 0.980142803914724 1.45433493570811 1.48379902387637 0.569295696478757 1 1 0 0.0667683 0.0709537 0.0330013 GeneID:2592,Genbank:NM_000155.3,HGNC:HGNC:4135,MIM:606999 galactose-1-phosphate uridylyltransferase hsa00052,hsa00520,hsa04917 Galactose metabolism|Amino sugar and nucleotide sugar metabolism|Prolactin signaling pathway GAMT 1012.21020338773 1019.35963602125 1005.0607707542 0.985972698190343 -0.0203803962869422 0.874985558014744 1 14.6623 15.572 14.4326 15.5219 GeneID:2593,Genbank:NM_000156.5,HGNC:HGNC:4136,MIM:601240 guanidinoacetate N-methyltransferase GO:0005634,GO:0005737,GO:0005829,GO:0006600,GO:0006601,GO:0006936,GO:0007283,GO:0008168,GO:0009887,GO:0030731,GO:0040014,GO:0046498,GO:0046500,GO:0070062 nucleus|cytoplasm|cytosol|creatine metabolic process|creatine biosynthetic process|muscle contraction|spermatogenesis|methyltransferase activity|animal organ morphogenesis|guanidinoacetate N-methyltransferase activity|regulation of multicellular organism growth|S-adenosylhomocysteine metabolic process|S-adenosylmethionine metabolic process|extracellular exosome hsa00260,hsa00330 Glycine, serine and threonine metabolism|Arginine and proline metabolism GAN 62.8415291686984 62.6702875198947 63.0127708175021 1.00546484324806 0.00786263772640899 1 1 0.572497 0.572654 0.733342 0.465706 GeneID:8139,Genbank:XM_017023734.1,HGNC:HGNC:4137,MIM:605379 gigaxonin GANAB 13806.2996770956 9103.89473102601 18508.7046231651 2.03305345349475 1.02364814734103 5.72930996443515e-15 3.29406378865701e-11 65.6851 69.6162 137.751 145.067 GeneID:23193,Genbank:NM_001278193.1,HGNC:HGNC:4138,MIM:104160 glucosidase II alpha subunit GO:0003723,GO:0005788,GO:0005794,GO:0005975,GO:0006457,GO:0016020,GO:0017177,GO:0030246,GO:0031012,GO:0033919,GO:0042470,GO:0070062 RNA binding|endoplasmic reticulum lumen|Golgi apparatus|carbohydrate metabolic process|protein folding|membrane|glucosidase II complex|carbohydrate binding|extracellular matrix|glucan 1,3-alpha-glucosidase activity|melanosome|extracellular exosome hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum GANC 540.994322832001 533.369811764694 548.618833899308 1.02858996103316 0.0406679782679505 0.799652793936276 1 2.37212 2.1204 2.6088 2.26587 GeneID:2595,Genbank:NM_001301409.1,HGNC:HGNC:4139,MIM:104180 glucosidase alpha, neutral C GO:0004558,GO:0030246,GO:0032450 alpha-1,4-glucosidase activity|carbohydrate binding|maltose alpha-glucosidase activity hsa00052,hsa00500 Galactose metabolism|Starch and sucrose metabolism GAP43 226.060271952491 231.607600023673 220.512943881308 0.952097184456679 -0.0708192520498574 0.737534619545783 1 1.85306 2.23112 2.06159 1.87507 GeneID:2596,Genbank:NM_001130064.1,HGNC:HGNC:4140,MIM:162060 growth associated protein 43 GAPDH 125432.502712058 122316.123423722 128548.882000393 1.05095614872522 0.0717024739275911 0.662136914288806 1 2458.73 2594.57 2576.69 2885.79 GeneID:2597,Genbank:NM_001289745.2,HGNC:HGNC:4141,MIM:138400 glyceraldehyde-3-phosphate dehydrogenase hsa00010,hsa04066,hsa05010 Glycolysis / Gluconeogenesis|HIF-1 signaling pathway|Alzheimer disease GAPDHS 2.94181923544568 2.00831188251439 3.87532658837698 1.92964380787565 0.948334565609095 0.689275062103934 1 0 0 0.0262879 0 GeneID:26330,Genbank:NM_014364.4,HGNC:HGNC:24864,MIM:609169 glyceraldehyde-3-phosphate dehydrogenase, spermatogenic GO:0004365,GO:0005634,GO:0005829,GO:0006094,GO:0030317,GO:0045821,GO:0050661,GO:0051287,GO:0061621 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|nucleus|cytosol|gluconeogenesis|flagellated sperm motility|positive regulation of glycolytic process|NADP binding|NAD binding|canonical glycolysis hsa00010 Glycolysis / Gluconeogenesis GAPVD1 995.304919346999 1001.37884762628 989.230991067716 0.987868870420658 -0.0176085435117597 0.940059915414493 1 2.97197 2.85965 3.26869 2.55833 GeneID:26130,Genbank:NM_001282680.2,HGNC:HGNC:23375,MIM:611714 GTPase activating protein and VPS9 domains 1 GO:0005085,GO:0005096,GO:0005768,GO:0005829,GO:0006897,GO:0007165,GO:0016020,GO:0017112,GO:0032794,GO:0045296,GO:0051223,GO:0061024 guanyl-nucleotide exchange factor activity|GTPase activator activity|endosome|cytosol|endocytosis|signal transduction|membrane|Rab guanyl-nucleotide exchange factor activity|GTPase activating protein binding|cadherin binding|regulation of protein transport|membrane organization GAR1 654.856532395981 679.177715827107 630.535348964855 0.928380502291635 -0.107211871152131 0.530108650219326 1 22.3914 20.7159 21.2793 18.1098 GeneID:54433,Genbank:NM_018983.3,HGNC:HGNC:14264,MIM:606468 GAR1 ribonucleoprotein GO:0000454,GO:0000784,GO:0001650,GO:0003723,GO:0005634,GO:0005654,GO:0005697,GO:0007004,GO:0031118,GO:0031429,GO:0034513,GO:0070034,GO:0072589,GO:0090661 snoRNA guided rRNA pseudouridine synthesis|nuclear chromosome, telomeric region|fibrillar center|RNA binding|nucleus|nucleoplasm|telomerase holoenzyme complex|telomere maintenance via telomerase|rRNA pseudouridine synthesis|box H/ACA snoRNP complex|box H/ACA snoRNA binding|telomerase RNA binding|box H/ACA scaRNP complex|box H/ACA telomerase RNP complex hsa03008 Ribosome biogenesis in eukaryotes GAREM1 36.2665776583689 36.187831504836 36.3453238119019 1.00435207915248 0.00626509977305721 1 1 0.134282 0.1685 0.137704 0.15504 GeneID:64762,Genbank:XM_024451236.1,HGNC:HGNC:26136 GRB2 associated regulator of MAPK1 subtype 1 GO:0005886,GO:0007173,GO:0008284,GO:0051781,GO:0070064,GO:0070374,GO:0071364 plasma membrane|epidermal growth factor receptor signaling pathway|positive regulation of cell proliferation|positive regulation of cell division|proline-rich region binding|positive regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus GAREM2 22.3233222640423 25.2621818377192 19.3844626903655 0.767331294457801 -0.382078500630066 0.552745283558078 1 0.18779 0.137089 0.131275 0.122632 GeneID:150946,Genbank:NM_001168241.1,HGNC:HGNC:27172 GRB2 associated regulator of MAPK1 subtype 2 GO:0070062 extracellular exosome GARNL3 28.8693751867391 29.6247981806506 28.1139521928277 0.94900063188246 -0.0755190470367757 0.910218360354363 1 0.117104 0.120537 0.13612 0.10386 GeneID:84253,Genbank:XM_005252268.2,HGNC:HGNC:25425 GTPase activating Rap/RanGAP domain like 3 GO:0005096,GO:0043231,GO:0051056 GTPase activator activity|intracellular membrane-bounded organelle|regulation of small GTPase mediated signal transduction GARS 7071.57489798436 7460.6018330773 6682.54796289142 0.895711647988463 -0.158893727527413 0.228292070300429 1 82.4746 82.9037 70.7705 78.9567 GeneID:2617,Genbank:NM_001316772.1,HGNC:HGNC:4162,MIM:600287 glycyl-tRNA synthetase hsa00970 Aminoacyl-tRNA biosynthesis GART 2717.6685124253 2955.63233374274 2479.70469110787 0.838976033249642 -0.253298496624831 0.066105769273509 0.907240788932751 23.7497 23.528 19.358 20.4132 GeneID:2618,Genbank:NM_001136006.1,HGNC:HGNC:4163,MIM:138440 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase GO:0003360,GO:0004637,GO:0004641,GO:0004644,GO:0005524,GO:0005829,GO:0006189,GO:0006544,GO:0009113,GO:0009168,GO:0010033,GO:0010035,GO:0021549,GO:0021987,GO:0046654,GO:0046872,GO:0070062 brainstem development|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|ATP binding|cytosol|'de novo' IMP biosynthetic process|glycine metabolic process|purine nucleobase biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|response to organic substance|response to inorganic substance|cerebellum development|cerebral cortex development|tetrahydrofolate biosynthetic process|metal ion binding|extracellular exosome hsa00230,hsa00670,hsa01523 Purine metabolism|One carbon pool by folate|Antifolate resistance GAS1 119.44240403275 104.633114643741 134.251693421758 1.28307079339904 0.359600773286575 0.196203577241437 1 2.5137 2.34515 3.73238 2.88347 GeneID:2619,Genbank:NM_002048.2,HGNC:HGNC:4165,MIM:139185 growth arrest specific 1 GO:0005886,GO:0007050,GO:0008589,GO:0010955,GO:0016021,GO:0035924,GO:0042981,GO:0045165,GO:0045930,GO:0046658,GO:0048589,GO:0060628 plasma membrane|cell cycle arrest|regulation of smoothened signaling pathway|negative regulation of protein processing|integral component of membrane|cellular response to vascular endothelial growth factor stimulus|regulation of apoptotic process|cell fate commitment|negative regulation of mitotic cell cycle|anchored component of plasma membrane|developmental growth|regulation of ER to Golgi vesicle-mediated transport hsa04340 Hedgehog signaling pathway GAS2 1.27026824386655 2.05633815719933 0.484198330533773 0.235466296649008 -2.08640751970762 0.631842364882622 1 0.0221137 0.0213586 0 0 GeneID:2620,Genbank:XM_011519972.3,HGNC:HGNC:4167,MIM:602835 growth arrest specific 2 GO:0005829,GO:0005884,GO:0006915,GO:0007050,GO:0008017,GO:0008360,GO:0016020 cytosol|actin filament|apoptotic process|cell cycle arrest|microtubule binding|regulation of cell shape|membrane GAS2L1 1013.98920091243 959.840482321202 1068.13791950365 1.11282857847437 0.154231375220887 0.319256453562371 1 13.0834 12.602 15.3304 14.5831 GeneID:10634,Genbank:XM_011529825.1,HGNC:HGNC:16955,MIM:602128 growth arrest specific 2 like 1 GO:0001578,GO:0005737,GO:0005856,GO:0007026,GO:0007050,GO:0008017,GO:0008093,GO:0009267,GO:0010629,GO:0030308,GO:0045647,GO:0046966,GO:0051726,GO:0097067 microtubule bundle formation|cytoplasm|cytoskeleton|negative regulation of microtubule depolymerization|cell cycle arrest|microtubule binding|cytoskeletal adaptor activity|cellular response to starvation|negative regulation of gene expression|negative regulation of cell growth|negative regulation of erythrocyte differentiation|thyroid hormone receptor binding|regulation of cell cycle|cellular response to thyroid hormone stimulus GAS2L3 478.477601190463 504.215467675785 452.73973470514 0.89790925453373 -0.155358445744366 0.677905526791317 1 2.80091 2.49359 2.99025 1.76418 GeneID:283431,Genbank:NM_174942.2,HGNC:HGNC:27475,MIM:617224 growth arrest specific 2 like 3 GO:0000226,GO:0003779,GO:0005737,GO:0005874,GO:0008017,GO:0015629,GO:0015630,GO:0030036 microtubule cytoskeleton organization|actin binding|cytoplasm|microtubule|microtubule binding|actin cytoskeleton|microtubule cytoskeleton|actin cytoskeleton organization GAS6 2647.04142025993 2389.65232011353 2904.43052040632 1.21541970602164 0.281454588100782 0.043851412978551 0.78388534136657 38.7626 40.4769 51.4912 46.9242 GeneID:2621,Genbank:NM_000820.3,HGNC:HGNC:4168,MIM:600441 growth arrest specific 6 hsa01521 EGFR tyrosine kinase inhibitor resistance GAS7 16.2688366219436 11.2138073152264 21.3238659286607 1.90157234998202 0.927192830882556 0.201406770584807 1 0.0419894 0.0463924 0.0702759 0.073855 GeneID:8522,Genbank:NM_201433.1,HGNC:HGNC:4169,MIM:603127 growth arrest specific 7 GAS8 418.10628869846 420.916189000706 415.296388396215 0.986648647043411 -0.0193916732370373 0.89784985582387 1 1.91676 2.2697 1.96667 2.22954 GeneID:2622,Genbank:NM_001286209.1,HGNC:HGNC:4166,MIM:605178 growth arrest specific 8 GO:0003351,GO:0005794,GO:0005874,GO:0005929,GO:0005930,GO:0007368,GO:0007420,GO:0008017,GO:0008285,GO:0017137,GO:0030317,GO:0031514,GO:0034613,GO:0035082,GO:0036064,GO:0036126,GO:0060294,GO:1904526 epithelial cilium movement|Golgi apparatus|microtubule|cilium|axoneme|determination of left/right symmetry|brain development|microtubule binding|negative regulation of cell proliferation|Rab GTPase binding|flagellated sperm motility|motile cilium|cellular protein localization|axoneme assembly|ciliary basal body|sperm flagellum|cilium movement involved in cell motility|regulation of microtubule binding GAST 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0.132904 0 GeneID:2520,Genbank:NM_000805.4,HGNC:HGNC:4164,MIM:137250 gastrin hsa04971 Gastric acid secretion GATA2 214.373541431299 230.041333268432 198.705749594167 0.863782811423287 -0.211259486516902 0.333812248547683 1 2.48344 2.61052 2.45601 2.12135 GeneID:2624,Genbank:NM_032638.4,HGNC:HGNC:4171,MIM:137295 GATA binding protein 2 GATA3 202.266855860323 178.671096958025 225.862614762621 1.26412508015039 0.338139219515693 0.140969801486713 1 2.11627 2.26045 3.15522 2.41257 GeneID:2625,Genbank:XM_005252443.5,HGNC:HGNC:4172,MIM:131320 GATA binding protein 3 hsa04658,hsa04659,hsa04928,hsa05321 Th1 and Th2 cell differentiation|Th17 cell differentiation|Parathyroid hormone synthesis, secretion and action|Inflammatory bowel disease (IBD) GATA4 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.019842 0 0 0 GeneID:2626,Genbank:NM_001308094.1,HGNC:HGNC:4173,MIM:600576 GATA binding protein 4 GO:0000977,GO:0001076,GO:0001085,GO:0001158,GO:0001228,GO:0001947,GO:0003197,GO:0003208,GO:0003215,GO:0003281,GO:0003289,GO:0003290,GO:0003677,GO:0003682,GO:0003713,GO:0005634,GO:0005654,GO:0006355,GO:0006366,GO:0007267,GO:0007492,GO:0007596,GO:0008134,GO:0008270,GO:0008584,GO:0009612,GO:0010507,GO:0010575,GO:0016604,GO:0019901,GO:0030513,GO:0033189,GO:0033613,GO:0035054,GO:0042493,GO:0043565,GO:0044212,GO:0045766,GO:0045893,GO:0045944,GO:0048617,GO:0051525,GO:0051891,GO:0060290,GO:0060413,GO:0060575,GO:0061049,GO:0070410,GO:0071333,GO:0086004,GO:0090575 RNA polymerase II regulatory region sequence-specific DNA binding|transcription factor activity, RNA polymerase II transcription factor binding|RNA polymerase II transcription factor binding|enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|heart looping|endocardial cushion development|cardiac ventricle morphogenesis|cardiac right ventricle morphogenesis|ventricular septum development|atrial septum primum morphogenesis|atrial septum secundum morphogenesis|DNA binding|chromatin binding|transcription coactivator activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|cell-cell signaling|endoderm development|blood coagulation|transcription factor binding|zinc ion binding|male gonad development|response to mechanical stimulus|negative regulation of autophagy|positive regulation of vascular endothelial growth factor production|nuclear body|protein kinase binding|positive regulation of BMP signaling pathway|response to vitamin A|activating transcription factor binding|embryonic heart tube anterior/posterior pattern specification|response to drug|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|embryonic foregut morphogenesis|NFAT protein binding|positive regulation of cardioblast differentiation|transdifferentiation|atrial septum morphogenesis|intestinal epithelial cell differentiation|cell growth involved in cardiac muscle cell development|co-SMAD binding|cellular response to glucose stimulus|regulation of cardiac muscle cell contraction|RNA polymerase II transcription factor complex hsa04022,hsa04218,hsa04530,hsa04919 cGMP-PKG signaling pathway|Cellular senescence|Tight junction|Thyroid hormone signaling pathway GATA6 124.428127531319 128.675022304121 120.181232758516 0.93399037829168 -0.0985204071177126 0.727265394686831 1 1.97006 1.97224 1.7783 1.88631 GeneID:2627,Genbank:NM_005257.5,HGNC:HGNC:4174,MIM:601656 GATA binding protein 6 GATAD1 949.143001245274 1017.70509137004 880.58091112051 0.865261379340325 -0.208792085009321 0.179773202590004 1 7.83265 7.76335 7.09042 6.55099 GeneID:57798,Genbank:NM_021167.4,HGNC:HGNC:29941,MIM:614518 GATA zinc finger domain containing 1 GO:0003700,GO:0005634,GO:0005654,GO:0008270,GO:0031497,GO:0043565 DNA binding transcription factor activity|nucleus|nucleoplasm|zinc ion binding|chromatin assembly|sequence-specific DNA binding GATAD2A 3390.13271476413 3370.36192496334 3409.90350456492 1.01173214642282 0.0168273906485352 0.912309731679766 1 17.9716 18.6697 19.4848 18.4579 GeneID:54815,Genbank:NM_001300946.2,HGNC:HGNC:29989,MIM:614997 GATA zinc finger domain containing 2A GO:0003700,GO:0005634,GO:0005654,GO:0006306,GO:0006351,GO:0008270,GO:0016581,GO:0016607,GO:0030674,GO:0043565,GO:0045892 DNA binding transcription factor activity|nucleus|nucleoplasm|DNA methylation|transcription, DNA-templated|zinc ion binding|NuRD complex|nuclear speck|protein binding, bridging|sequence-specific DNA binding|negative regulation of transcription, DNA-templated GATAD2B 956.21150525541 974.156380180734 938.266630330087 0.963158122678427 -0.0541554286177826 0.74673322849132 1 4.71935 4.23876 4.59817 4.15461 GeneID:57459,Genbank:NM_020699.3,HGNC:HGNC:30778,MIM:614998 GATA zinc finger domain containing 2B GO:0000790,GO:0003700,GO:0005654,GO:0006351,GO:0008270,GO:0016607,GO:0043044,GO:0043234,GO:0043565 nuclear chromatin|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|zinc ion binding|nuclear speck|ATP-dependent chromatin remodeling|protein complex|sequence-specific DNA binding GATB 512.500363842105 491.436410606172 533.564317078038 1.08572402362272 0.11865743615446 0.496347578944107 1 6.76089 6.74285 7.5574 7.36985 GeneID:5188,Genbank:NM_004564.2,HGNC:HGNC:8849,MIM:603645 glutamyl-tRNA amidotransferase subunit B GO:0005524,GO:0005739,GO:0006412,GO:0008135,GO:0030956,GO:0032543,GO:0050567,GO:0070681 ATP binding|mitochondrion|translation|translation factor activity, RNA binding|glutamyl-tRNA(Gln) amidotransferase complex|mitochondrial translation|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|glutaminyl-tRNAGln biosynthesis via transamidation hsa00970 Aminoacyl-tRNA biosynthesis GATC 1181.69957137037 1224.57000692327 1138.82913581748 0.92998287511449 -0.104723944489134 0.479299802235303 1 9.18031 10.3594 9.09444 9.26313 GeneID:283459,Genbank:NM_176818.2,HGNC:HGNC:25068,MIM:617210 glutamyl-tRNA amidotransferase subunit C GO:0005524,GO:0005739,GO:0006450,GO:0030956,GO:0032543,GO:0050567,GO:0070681 ATP binding|mitochondrion|regulation of translational fidelity|glutamyl-tRNA(Gln) amidotransferase complex|mitochondrial translation|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|glutaminyl-tRNAGln biosynthesis via transamidation hsa00970 Aminoacyl-tRNA biosynthesis GATD1 1235.29526848919 1080.25193437695 1390.33860260143 1.28705032442578 0.36406846488735 0.0148091762826715 0.507888152769308 7.97922 8.2857 10.3804 10.912 GeneID:347862,Genbank:NM_001318822.1,HGNC:HGNC:26616 glutamine amidotransferase like class 1 domain containing 1 GO:0070062 extracellular exosome GATD3A 161.432069776843 156.15723843331 166.706901120375 1.0675579485966 0.0943143835543163 0.735164199732717 1 1.70043 2.06914 1.89755 2.14696 GeneID:8209,Genbank:NM_004649.7,HGNC:HGNC:1273,MIM:601659 glutamine amidotransferase like class 1 domain containing 3A GO:0005739 mitochondrion GATD3B 195.955297785535 196.611633731708 195.298961839363 0.993323528890786 -0.00966440985631822 0.943184731948404 1 1.43692 1.44612 1.60654 1.63091 GeneID:102724023,Genbank:XM_017028514.2,HGNC:HGNC:53816 glutamine amidotransferase like class 1 domain containing 3B GO:0005739 mitochondrion GATM 364.161009870795 324.575053569808 403.746966171783 1.24392482333812 0.314899298752658 0.140465228831989 1 4.01042 4.04966 5.96457 4.3226 GeneID:2628,Genbank:NM_001321015.1,HGNC:HGNC:4175,MIM:602360 glycine amidinotransferase GO:0005739,GO:0005743,GO:0005758,GO:0006600,GO:0006601,GO:0007275,GO:0007611,GO:0014889,GO:0015068,GO:0070062 mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|creatine metabolic process|creatine biosynthetic process|multicellular organism development|learning or memory|muscle atrophy|glycine amidinotransferase activity|extracellular exosome hsa00260,hsa00330 Glycine, serine and threonine metabolism|Arginine and proline metabolism GBA 3160.25529030933 2806.50182507281 3514.00875554584 1.25209566021026 0.324344788499673 0.01768854449442 0.546850871863472 36.5047 37.0565 48.1943 45.4171 GeneID:2629,Genbank:NM_001171811.1,HGNC:HGNC:4177,MIM:606463 glucosylceramidase beta hsa00511,hsa00600,hsa04142 Other glycan degradation|Sphingolipid metabolism|Lysosome GBA2 2666.54923922454 2684.00664289625 2649.09183555282 0.986991534676027 -0.0188903839982828 0.871184012544374 1 19.7946 21.4236 22.8147 19.2189 GeneID:57704,Genbank:NM_001330660.1,HGNC:HGNC:18986,MIM:609471 glucosylceramidase beta 2 GO:0000139,GO:0004348,GO:0005789,GO:0005790,GO:0005886,GO:0006680,GO:0006687,GO:0008206,GO:0008422,GO:0016021,GO:0016139,GO:0021954 Golgi membrane|glucosylceramidase activity|endoplasmic reticulum membrane|smooth endoplasmic reticulum|plasma membrane|glucosylceramide catabolic process|glycosphingolipid metabolic process|bile acid metabolic process|beta-glucosidase activity|integral component of membrane|glycoside catabolic process|central nervous system neuron development hsa00511,hsa00600 Other glycan degradation|Sphingolipid metabolism GBE1 3665.39846827255 3591.82784502165 3738.96909152345 1.04096556206215 0.0579223411983536 0.655411647622529 1 43.8928 43.1385 48.3257 43.2221 GeneID:2632,Genbank:NM_000158.3,HGNC:HGNC:4180,MIM:607839 1,4-alpha-glucan branching enzyme 1 GO:0003844,GO:0004553,GO:0005829,GO:0005977,GO:0005978,GO:0006091,GO:0030246,GO:0043169,GO:0070062,GO:0102752 1,4-alpha-glucan branching enzyme activity|hydrolase activity, hydrolyzing O-glycosyl compounds|cytosol|glycogen metabolic process|glycogen biosynthetic process|generation of precursor metabolites and energy|carbohydrate binding|cation binding|extracellular exosome|1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis) hsa00500 Starch and sucrose metabolism GBF1 3109.87451315321 2858.68952505372 3361.05950125269 1.17573436072584 0.233562142016577 0.0901502446398791 0.979717040875575 13.0905 14.1853 17.5725 15.0725 GeneID:8729,Genbank:NM_001199378.1,HGNC:HGNC:4181,MIM:603698 golgi brefeldin A resistant guanine nucleotide exchange factor 1 GO:0000139,GO:0002263,GO:0005085,GO:0005086,GO:0005547,GO:0005739,GO:0005777,GO:0005788,GO:0005793,GO:0005794,GO:0005795,GO:0005801,GO:0005802,GO:0005811,GO:0005829,GO:0006888,GO:0006890,GO:0006892,GO:0006895,GO:0007030,GO:0007346,GO:0015031,GO:0016020,GO:0016032,GO:0030593,GO:0031252,GO:0032012,GO:0034067,GO:0042147,GO:0048205,GO:0061162,GO:0070973,GO:0080025,GO:0090166,GO:0097111,GO:0098586,GO:1903409,GO:1903420,GO:2000008 Golgi membrane|cell activation involved in immune response|guanyl-nucleotide exchange factor activity|ARF guanyl-nucleotide exchange factor activity|phosphatidylinositol-3,4,5-trisphosphate binding|mitochondrion|peroxisome|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|Golgi stack|cis-Golgi network|trans-Golgi network|lipid droplet|cytosol|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|post-Golgi vesicle-mediated transport|Golgi to endosome transport|Golgi organization|regulation of mitotic cell cycle|protein transport|membrane|viral process|neutrophil chemotaxis|cell leading edge|regulation of ARF protein signal transduction|protein localization to Golgi apparatus|retrograde transport, endosome to Golgi|COPI coating of Golgi vesicle|establishment of monopolar cell polarity|protein localization to endoplasmic reticulum exit site|phosphatidylinositol-3,5-bisphosphate binding|Golgi disassembly|endoplasmic reticulum-Golgi intermediate compartment organization|cellular response to virus|reactive oxygen species biosynthetic process|protein localization to endoplasmic reticulum tubular network|regulation of protein localization to cell surface hsa04144 Endocytosis GBP1 411.249832390042 336.201480046983 486.298184733102 1.44644867317402 0.532515130546401 0.529753297369754 1 2.82707 2.5421 5.84029 2.02543 GeneID:2633,Genbank:NM_002053.2,HGNC:HGNC:4182,MIM:600411 guanylate binding protein 1 hsa04621 NOD-like receptor signaling pathway GBP2 761.241408254781 738.293042019461 784.1897744901 1.06216600977993 0.0870092678077876 0.583482422848234 1 5.50066 5.58514 6.64814 5.33825 GeneID:2634,Genbank:NM_004120.4,HGNC:HGNC:4183,MIM:600412 guanylate binding protein 2 GO:0000139,GO:0003924,GO:0005525,GO:0005654,GO:0005829,GO:0006955,GO:0015629,GO:0048471,GO:0060333,GO:0060337 Golgi membrane|GTPase activity|GTP binding|nucleoplasm|cytosol|immune response|actin cytoskeleton|perinuclear region of cytoplasm|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway hsa04621 NOD-like receptor signaling pathway GBP3 203.128551296606 151.71716985037 254.539932742842 1.67772660796322 0.74650764219599 0.397958127087685 1 1.1946 0.922097 2.64172 0.889914 GeneID:2635,Genbank:XM_011541234.2,HGNC:HGNC:4184,MIM:600413 guanylate binding protein 3 GO:0000139,GO:0003924,GO:0005525,GO:0048471,GO:0051607 Golgi membrane|GTPase activity|GTP binding|perinuclear region of cytoplasm|defense response to virus hsa04621 NOD-like receptor signaling pathway GBP4 1.21267075646793 0 2.42534151293585 Inf Inf 0.450088312527682 1 0 0 0.0362504 0 GeneID:115361,Genbank:NM_052941.4,HGNC:HGNC:20480,MIM:612466 guanylate binding protein 4 GO:0000139,GO:0003924,GO:0005525,GO:0005634,GO:0048471 Golgi membrane|GTPase activity|GTP binding|nucleus|perinuclear region of cytoplasm hsa04621 NOD-like receptor signaling pathway GBP5 256.909518572995 286.023108949447 227.795928196543 0.79642490787975 -0.328389753396162 0.122471244909242 1 2.34061 2.09416 1.99915 1.56859 GeneID:115362,Genbank:NM_001134486.2,HGNC:HGNC:19895,MIM:611467 guanylate binding protein 5 GO:0000139,GO:0003924,GO:0005525,GO:0006954,GO:0016020,GO:0031410,GO:0042802,GO:0045089,GO:0050702,GO:0051289,GO:0071346,GO:0072616,GO:1900017,GO:1900227 Golgi membrane|GTPase activity|GTP binding|inflammatory response|membrane|cytoplasmic vesicle|identical protein binding|positive regulation of innate immune response|interleukin-1 beta secretion|protein homotetramerization|cellular response to interferon-gamma|interleukin-18 secretion|positive regulation of cytokine production involved in inflammatory response|positive regulation of NLRP3 inflammasome complex assembly hsa04621 NOD-like receptor signaling pathway GBX1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:2636,Genbank:XM_017011965.1,HGNC:HGNC:4185,MIM:603354 gastrulation brain homeobox 1 GO:0005634,GO:0006351,GO:0006355,GO:0007628,GO:0019230,GO:0021522,GO:0043565,GO:0048663,GO:0097374 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|adult walking behavior|proprioception|spinal cord motor neuron differentiation|sequence-specific DNA binding|neuron fate commitment|sensory neuron axon guidance GBX2 29.8251557329061 27.6645125728211 31.9857988929911 1.15620323361184 0.20939501233098 0.714740750179926 1 0.598071 0.63448 0.876409 0.793426 GeneID:2637,Genbank:NM_001485.3,HGNC:HGNC:4186,MIM:601135 gastrulation brain homeobox 2 GO:0000979,GO:0001190,GO:0001228,GO:0001569,GO:0001755,GO:0003700,GO:0005634,GO:0007399,GO:0007411,GO:0021549,GO:0021555,GO:0021568,GO:0021794,GO:0021884,GO:0021930,GO:0042472,GO:0048483 RNA polymerase II core promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|branching involved in blood vessel morphogenesis|neural crest cell migration|DNA binding transcription factor activity|nucleus|nervous system development|axon guidance|cerebellum development|midbrain-hindbrain boundary morphogenesis|rhombomere 2 development|thalamus development|forebrain neuron development|cerebellar granule cell precursor proliferation|inner ear morphogenesis|autonomic nervous system development GC 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0184375 0 0 0 GeneID:2638,Genbank:NM_001204306.1,HGNC:HGNC:4187,MIM:139200 GC, vitamin D binding protein GO:0003779,GO:0005499,GO:0005576,GO:0005615,GO:0005829,GO:0042359,GO:0043202,GO:0051180,GO:0070062,GO:0072562,GO:0090482,GO:1902118 actin binding|vitamin D binding|extracellular region|extracellular space|cytosol|vitamin D metabolic process|lysosomal lumen|vitamin transport|extracellular exosome|blood microparticle|vitamin transmembrane transporter activity|calcidiol binding GCA 189.544433317082 205.585789445248 173.503077188916 0.843944893550744 -0.24477929547693 0.300401932943317 1 0.55512 0.511567 0.455622 0.435314 GeneID:25801,Genbank:NM_001330268.1,HGNC:HGNC:15990,MIM:607030 grancalcin GO:0004198,GO:0005509,GO:0005576,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0035578,GO:0042803,GO:0043312,GO:0046982,GO:0061025,GO:0070062 calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|extracellular region|cytoplasm|cytosol|plasma membrane|proteolysis|azurophil granule lumen|protein homodimerization activity|neutrophil degranulation|protein heterodimerization activity|membrane fusion|extracellular exosome GCAT 550.164525523496 546.929131886084 553.399919160908 1.01183112563873 0.0169685246827606 0.937484310733633 1 8.20303 8.0355 8.38141 9.2327 GeneID:23464,Genbank:XM_017028674.2,HGNC:HGNC:4188,MIM:607422 glycine C-acetyltransferase GO:0005654,GO:0005739,GO:0005743,GO:0006520,GO:0008890,GO:0009058,GO:0016607,GO:0019518,GO:0030170 nucleoplasm|mitochondrion|mitochondrial inner membrane|cellular amino acid metabolic process|glycine C-acetyltransferase activity|biosynthetic process|nuclear speck|L-threonine catabolic process to glycine|pyridoxal phosphate binding hsa00260 Glycine, serine and threonine metabolism GCC1 1154.76251650192 1110.48043981743 1199.0445931864 1.07975300617049 0.110701333198064 0.450063959136532 1 11.1618 10.3654 12.8747 10.6009 GeneID:79571,Genbank:NM_024523.5,HGNC:HGNC:19095,MIM:607418 GRIP and coiled-coil domain containing 1 GO:0000139,GO:0005794,GO:0005829,GO:0005886 Golgi membrane|Golgi apparatus|cytosol|plasma membrane GCC2 49.8224506685196 52.1386567053654 47.5062446316738 0.911152063240346 -0.134236247692788 0.804019187651754 1 0.196799 0.161216 0.214249 0.107085 GeneID:9648,Genbank:XM_006712870.3,HGNC:HGNC:23218,MIM:612711 GRIP and coiled-coil domain containing 2 GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0006622,GO:0016020,GO:0031023,GO:0034067,GO:0034453,GO:0034499,GO:0042147,GO:0042802,GO:0070861,GO:0071955,GO:0090161 nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|protein targeting to lysosome|membrane|microtubule organizing center organization|protein localization to Golgi apparatus|microtubule anchoring|late endosome to Golgi transport|retrograde transport, endosome to Golgi|identical protein binding|regulation of protein exit from endoplasmic reticulum|recycling endosome to Golgi transport|Golgi ribbon formation GCDH 456.577912670865 480.396108080324 432.759717261406 0.900839348992077 -0.150658248646086 0.388045153631915 1 4.1832 4.74509 4.12216 4.03372 GeneID:2639,Genbank:NM_000159.3,HGNC:HGNC:4189,MIM:608801 glutaryl-CoA dehydrogenase GO:0000062,GO:0004361,GO:0005739,GO:0005759,GO:0006554,GO:0006568,GO:0033539,GO:0046949,GO:0050660 fatty-acyl-CoA binding|glutaryl-CoA dehydrogenase activity|mitochondrion|mitochondrial matrix|lysine catabolic process|tryptophan metabolic process|fatty acid beta-oxidation using acyl-CoA dehydrogenase|fatty-acyl-CoA biosynthetic process|flavin adenine dinucleotide binding hsa00071,hsa00310,hsa00380 Fatty acid degradation|Lysine degradation|Tryptophan metabolism GCFC2 171.410708606166 185.320374176473 157.50104303586 0.849885198730918 -0.234660117645449 0.335768831319018 1 0.375316 0.403934 0.34829 0.326766 GeneID:6936,Genbank:XM_011533074.3,HGNC:HGNC:1317,MIM:189901 GC-rich sequence DNA-binding factor 2 GO:0000122,GO:0000245,GO:0000398,GO:0000978,GO:0001078,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006351,GO:0006355,GO:0045892,GO:0071008 negative regulation of transcription from RNA polymerase II promoter|spliceosomal complex assembly|mRNA splicing, via spliceosome|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|nucleoplasm|nucleolus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|U2-type post-mRNA release spliceosomal complex GCH1 136.463740019088 149.824527827442 123.102952210734 0.821647523244763 -0.283408466825772 0.283828691842859 1 1.93189 1.85072 1.77287 1.49424 GeneID:2643,Genbank:NM_001024071.1,HGNC:HGNC:4193,MIM:600225 GTP cyclohydrolase 1 GO:0003924,GO:0003934,GO:0005509,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006729,GO:0006809,GO:0008217,GO:0008270,GO:0010460,GO:0014916,GO:0030742,GO:0031369,GO:0031410,GO:0031965,GO:0032496,GO:0034341,GO:0034612,GO:0035998,GO:0042311,GO:0042416,GO:0042559,GO:0042803,GO:0043234,GO:0044306,GO:0045776,GO:0046654,GO:0048265,GO:0050662,GO:0050884,GO:0051000,GO:0051019,GO:0051186,GO:0051260,GO:0051291,GO:2000121 GTPase activity|GTP cyclohydrolase I activity|calcium ion binding|GTP binding|nucleus|nucleoplasm|cytoplasm|cytosol|tetrahydrobiopterin biosynthetic process|nitric oxide biosynthetic process|regulation of blood pressure|zinc ion binding|positive regulation of heart rate|regulation of lung blood pressure|GTP-dependent protein binding|translation initiation factor binding|cytoplasmic vesicle|nuclear membrane|response to lipopolysaccharide|response to interferon-gamma|response to tumor necrosis factor|7,8-dihydroneopterin 3'-triphosphate biosynthetic process|vasodilation|dopamine biosynthetic process|pteridine-containing compound biosynthetic process|protein homodimerization activity|protein complex|neuron projection terminus|negative regulation of blood pressure|tetrahydrofolate biosynthetic process|response to pain|coenzyme binding|neuromuscular process controlling posture|positive regulation of nitric-oxide synthase activity|mitogen-activated protein kinase binding|cofactor metabolic process|protein homooligomerization|protein heterooligomerization|regulation of removal of superoxide radicals hsa00790 Folate biosynthesis GCHFR 0.975139704544532 0.980142803914724 0.97013660517434 0.989791080748215 -0.0148040531050533 1 1 0 0.167574 0.179006 0 GeneID:2644,Genbank:NM_005258.2,HGNC:HGNC:4194,MIM:602437 GTP cyclohydrolase I feedback regulator GO:0004857,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006809,GO:0009890,GO:0016597,GO:0030425,GO:0030742,GO:0031965,GO:0042133,GO:0042470,GO:0043105,GO:0043234,GO:0044549,GO:0051186,GO:0051291 enzyme inhibitor activity|nucleus|nucleoplasm|cytoplasm|cytosol|nitric oxide biosynthetic process|negative regulation of biosynthetic process|amino acid binding|dendrite|GTP-dependent protein binding|nuclear membrane|neurotransmitter metabolic process|melanosome|negative regulation of GTP cyclohydrolase I activity|protein complex|GTP cyclohydrolase binding|cofactor metabolic process|protein heterooligomerization GCK 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0 GeneID:2645,Genbank:NM_001354800.1,HGNC:HGNC:4195,MIM:138079 glucokinase hsa00010,hsa00052,hsa00500,hsa00520,hsa00524,hsa04910,hsa04911,hsa04917,hsa04922,hsa04930,hsa04950,hsa05230 Glycolysis / Gluconeogenesis|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism|Neomycin, kanamycin and gentamicin biosynthesis|Insulin signaling pathway|Insulin secretion|Prolactin signaling pathway|Glucagon signaling pathway|Type II diabetes mellitus|Maturity onset diabetes of the young|Central carbon metabolism in cancer GCKR 2.02395039874818 2.59443583384164 1.45346496365472 0.560223900971387 -0.835924560105201 0.824517683088342 1 0.0358931 0.0323179 0 0.0313987 GeneID:2646,Genbank:NM_001486.3,HGNC:HGNC:4196,MIM:600842 glucokinase regulator GCLC 1015.12243146704 1073.55259688211 956.692266051973 0.891146152345466 -0.166266034663636 0.285546931893431 1 10.1427 9.59928 9.89347 8.10576 GeneID:2729,Genbank:NM_001197115.1,HGNC:HGNC:4311,MIM:606857 glutamate-cysteine ligase catalytic subunit hsa00270,hsa00480,hsa04216 Cysteine and methionine metabolism|Glutathione metabolism|Ferroptosis GCLM 1506.64223416694 1651.85509014772 1361.42937818616 0.824182088553793 -0.278964984138893 0.0554033125897402 0.855410907895938 10.0974 10.7488 9.90078 7.72308 GeneID:2730,Genbank:NM_001308253.1,HGNC:HGNC:4312,MIM:601176 glutamate-cysteine ligase modifier subunit hsa00270,hsa00480,hsa04216 Cysteine and methionine metabolism|Glutathione metabolism|Ferroptosis GCM1 3.70387601143599 4.01662376502878 3.3911282578432 0.844273314162125 -0.244217980842153 0.953362246986353 1 0.0101229 0.0189942 0.00965185 0.0179663 GeneID:8521,Genbank:XM_017011390.2,HGNC:HGNC:4197,MIM:603715 glial cells missing homolog 1 GO:0000978,GO:0000981,GO:0001077,GO:0003677,GO:0003700,GO:0005634,GO:0005667,GO:0006355,GO:0006366,GO:0008134,GO:0008270,GO:0009653,GO:0042063,GO:0042826,GO:0045944,GO:0060018,GO:0060143,GO:0060670,GO:0060706,GO:0060800 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|transcription factor complex|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription factor binding|zinc ion binding|anatomical structure morphogenesis|gliogenesis|histone deacetylase binding|positive regulation of transcription from RNA polymerase II promoter|astrocyte fate commitment|positive regulation of syncytium formation by plasma membrane fusion|branching involved in labyrinthine layer morphogenesis|cell differentiation involved in embryonic placenta development|regulation of cell differentiation involved in embryonic placenta development hsa04928 Parathyroid hormone synthesis, secretion and action GCN1 5123.91298332229 5190.27532236456 5057.55064428001 0.974428200848488 -0.0373722081173346 0.753861045281022 1 21.0915 22.8152 22.116 21.383 GeneID:10985,Genbank:NM_006836.1,HGNC:HGNC:4199,MIM:605614 GCN1, eIF2 alpha kinase activator homolog GO:0003723,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006417,GO:0008135,GO:0016020,GO:0019887,GO:0019901,GO:0033674,GO:0034198,GO:0036003,GO:0043022,GO:0045296,GO:1990253 RNA binding|cytoplasm|cytosol|ribosome|polysome|regulation of translation|translation factor activity, RNA binding|membrane|protein kinase regulator activity|protein kinase binding|positive regulation of kinase activity|cellular response to amino acid starvation|positive regulation of transcription from RNA polymerase II promoter in response to stress|ribosome binding|cadherin binding|cellular response to leucine starvation GCNA 48.4116708745595 47.8819015669119 48.9414401822071 1.02212816493544 0.0315761075512484 0.955732666020209 1 0.376915 0.338571 0.332807 0.392489 GeneID:93953,Genbank:NM_052957.4,HGNC:HGNC:15805,MIM:300369 germ cell nuclear acidic peptidase GO:0005634,GO:0080111 nucleus|DNA demethylation GCNT1 206.848282624328 225.149410903111 188.547154345545 0.837431257711276 -0.255957326196024 0.413884517380731 1 1.55347 1.18648 1.37562 0.937554 GeneID:2650,Genbank:NM_001097634.1,HGNC:HGNC:4203,MIM:600391 glucosaminyl (N-acetyl) transferase 1, core 2 hsa00512 Mucin type O-glycan biosynthesis GCNT2 1722.05449047684 1577.26142684828 1866.84755410539 1.18360058917802 0.243182319795871 0.0902929233321799 0.979717040875575 5.08289 5.58999 6.72293 6.07011 GeneID:2651,Genbank:XM_005248999.2,HGNC:HGNC:4204,MIM:600429 glucosaminyl (N-acetyl) transferase 2 (I blood group) hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series GCNT3 1.45640149936651 0.490071401957362 2.42273159677566 4.94362982026534 2.30557071806793 0.554025919298353 1 0 0.0160344 0.0327853 0.0458707 GeneID:9245,Genbank:NM_004751.2,HGNC:HGNC:4205,MIM:606836 glucosaminyl (N-acetyl) transferase 3, mucin type hsa00512 Mucin type O-glycan biosynthesis GCNT4 1.45520490776151 0 2.91040981552302 Inf Inf 0.415774444330224 1 0 0 0.0703174 0 GeneID:51301,Genbank:NM_016591.2,HGNC:HGNC:17973,MIM:616782 glucosaminyl (N-acetyl) transferase 4, core 2 hsa00512 Mucin type O-glycan biosynthesis GCNT7 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:140687,Genbank:NM_080615.1,HGNC:HGNC:16099 glucosaminyl (N-acetyl) transferase family member 7 GO:0000139,GO:0006486,GO:0008375,GO:0016021 Golgi membrane|protein glycosylation|acetylglucosaminyltransferase activity|integral component of membrane GCSH 481.026030872517 523.011685739544 439.040376005491 0.839446589773006 -0.25248955902927 0.153369665941936 1 2.90431 2.329 2.57032 2.87879 GeneID:2653,Genbank:NM_004483.4,HGNC:HGNC:4208,MIM:238330 glycine cleavage system protein H hsa00260,hsa00630 Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism GDA 7.66896959258625 6.61105959887042 8.72687958630208 1.32004249179559 0.400584370277752 0.765654318118199 1 0.0278094 0.0375969 0.0698036 0.0249884 GeneID:9615,Genbank:NM_001242507.2,HGNC:HGNC:4212,MIM:139260 guanine deaminase GO:0005622,GO:0005829,GO:0006139,GO:0006147,GO:0006195,GO:0007399,GO:0008270,GO:0008892,GO:0046098,GO:0070062 intracellular|cytosol|nucleobase-containing compound metabolic process|guanine catabolic process|purine nucleotide catabolic process|nervous system development|zinc ion binding|guanine deaminase activity|guanine metabolic process|extracellular exosome hsa00230 Purine metabolism GDAP1 154.056951369298 164.651131400001 143.462771338594 0.871313607861382 -0.198736020065262 0.443680873563026 1 1.51692 1.41707 1.49229 1.13957 GeneID:54332,Genbank:NM_018972.2,HGNC:HGNC:15968,MIM:606598 ganglioside induced differentiation associated protein 1 GDAP2 315.38677794548 308.969203946326 321.804351944634 1.0415418359965 0.0587207898082107 0.741301534267523 1 0.841404 0.687517 0.839792 0.704596 GeneID:54834,Genbank:XM_005270959.3,HGNC:HGNC:18010 ganglioside induced differentiation associated protein 2 GO:0005765,GO:0032526 lysosomal membrane|response to retinoic acid GDE1 2084.30906065419 1978.98737893264 2189.63074237573 1.10643997313247 0.145925183797582 0.300631977656375 1 25.71 26.8368 31.27 27.474 GeneID:51573,Genbank:NM_001324066.1,HGNC:HGNC:29644,MIM:605943 glycerophosphodiester phosphodiesterase 1 GO:0004622,GO:0005886,GO:0006629,GO:0006644,GO:0008889,GO:0016021,GO:0030659,GO:0046475,GO:0046872,GO:0047395,GO:0070291 lysophospholipase activity|plasma membrane|lipid metabolic process|phospholipid metabolic process|glycerophosphodiester phosphodiesterase activity|integral component of membrane|cytoplasmic vesicle membrane|glycerophospholipid catabolic process|metal ion binding|glycerophosphoinositol glycerophosphodiesterase activity|N-acylethanolamine metabolic process GDF11 753.993522816558 668.118812991898 839.868232641217 1.25706418725168 0.330058317431804 0.0410084640860707 0.759435523043776 4.04007 4.39377 5.60968 5.22622 GeneID:10220,Genbank:XM_006719194.3,HGNC:HGNC:4216,MIM:603936 growth differentiation factor 11 GO:0001501,GO:0001656,GO:0001657,GO:0005125,GO:0005160,GO:0005615,GO:0005654,GO:0007399,GO:0007498,GO:0008083,GO:0008285,GO:0010862,GO:0021512,GO:0031016,GO:0042981,GO:0043231,GO:0043234,GO:0043408,GO:0045596,GO:0048468,GO:0048469,GO:0048593,GO:0060021,GO:0060395 skeletal system development|metanephros development|ureteric bud development|cytokine activity|transforming growth factor beta receptor binding|extracellular space|nucleoplasm|nervous system development|mesoderm development|growth factor activity|negative regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|spinal cord anterior/posterior patterning|pancreas development|regulation of apoptotic process|intracellular membrane-bounded organelle|protein complex|regulation of MAPK cascade|negative regulation of cell differentiation|cell development|cell maturation|camera-type eye morphogenesis|palate development|SMAD protein signal transduction hsa04060 Cytokine-cytokine receptor interaction GDF15 4148.1726337549 4483.08405038417 3813.26121712562 0.85058882998164 -0.233466185416168 0.458651674052283 1 127.827 130.134 88.5004 132.789 GeneID:9518,Genbank:XM_024451789.1,HGNC:HGNC:30142,MIM:605312 growth differentiation factor 15 hsa04060 Cytokine-cytokine receptor interaction GDF3 1.96635291134955 0.538097676642304 3.39460814605679 6.30853522215322 2.65730506494608 0.354870116513622 1 0.0388149 0 0.219039 0.034165 GeneID:9573,Genbank:NM_020634.2,HGNC:HGNC:4218,MIM:606522 growth differentiation factor 3 hsa04060 Cytokine-cytokine receptor interaction GDF5 3.05755756274473 5.6309167949557 0.484198330533773 0.0859892532895405 -3.53969982292143 0.111768870284577 1 0.0334092 0.0877577 0 0.0145334 GeneID:8200,Genbank:NM_001319138.1,HGNC:HGNC:4220,MIM:601146 growth differentiation factor 5 hsa04060,hsa04350,hsa04390 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway GDF6 410.781969784551 454.690864114477 366.873075454624 0.806862649789806 -0.309604986851251 0.095219027593833 1 5.98571 5.37721 4.9534 4.44632 GeneID:392255,Genbank:NM_001001557.3,HGNC:HGNC:4221,MIM:601147 growth differentiation factor 6 GO:0005125,GO:0005160,GO:0005615,GO:0006915,GO:0008083,GO:0010862,GO:0030509,GO:0032332,GO:0032924,GO:0042803,GO:0042981,GO:0043408,GO:0045444,GO:0045666,GO:0045893,GO:0048468,GO:0060389,GO:0060395,GO:1900745,GO:1990009 cytokine activity|transforming growth factor beta receptor binding|extracellular space|apoptotic process|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|BMP signaling pathway|positive regulation of chondrocyte differentiation|activin receptor signaling pathway|protein homodimerization activity|regulation of apoptotic process|regulation of MAPK cascade|fat cell differentiation|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|cell development|pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|positive regulation of p38MAPK cascade|retinal cell apoptotic process hsa04060,hsa04350,hsa04390 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Hippo signaling pathway GDF7 1.5397520682144 2.59443583384164 0.48506830258717 0.186964848488436 -2.41916104230609 0.49972398725951 1 0.0165243 0.00999071 0.00520092 0 GeneID:151449,Genbank:NM_182828.3,HGNC:HGNC:4222,MIM:604651 growth differentiation factor 7 GO:0005125,GO:0005160,GO:0005615,GO:0007411,GO:0008083,GO:0010862,GO:0021509,GO:0021527,GO:0022612,GO:0030509,GO:0030855,GO:0030901,GO:0032924,GO:0042803,GO:0042981,GO:0043408,GO:0045165,GO:0045666,GO:0045893,GO:0048468,GO:0048608,GO:0048754,GO:0048853,GO:0060389,GO:0060395,GO:0060571,GO:2001051 cytokine activity|transforming growth factor beta receptor binding|extracellular space|axon guidance|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|roof plate formation|spinal cord association neuron differentiation|gland morphogenesis|BMP signaling pathway|epithelial cell differentiation|midbrain development|activin receptor signaling pathway|protein homodimerization activity|regulation of apoptotic process|regulation of MAPK cascade|cell fate commitment|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|cell development|reproductive structure development|branching morphogenesis of an epithelial tube|forebrain morphogenesis|pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|morphogenesis of an epithelial fold|positive regulation of tendon cell differentiation hsa04060,hsa04350,hsa04360,hsa04390 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Axon guidance|Hippo signaling pathway GDF9 82.8222721344436 83.7619581134224 81.8825861554648 0.977562941455921 -0.0327384999835251 0.979608935068326 1 0.109559 0.0340363 0.0926522 0.0865421 GeneID:2661,Genbank:NM_001288824.2,HGNC:HGNC:4224,MIM:601918 growth differentiation factor 9 GO:0001555,GO:0005125,GO:0005160,GO:0005615,GO:0005737,GO:0007179,GO:0007292,GO:0008083,GO:0008284,GO:0010862,GO:0030308,GO:0030509,GO:0042981,GO:0043408,GO:0048468,GO:0060395,GO:2000870 oocyte growth|cytokine activity|transforming growth factor beta receptor binding|extracellular space|cytoplasm|transforming growth factor beta receptor signaling pathway|female gamete generation|growth factor activity|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of cell growth|BMP signaling pathway|regulation of apoptotic process|regulation of MAPK cascade|cell development|SMAD protein signal transduction|regulation of progesterone secretion hsa04060 Cytokine-cytokine receptor interaction GDI1 7618.38726865602 7029.32482840232 8207.44970890972 1.16760142819793 0.223547880643476 0.0920582938160194 0.985009977016794 99.1804 104.145 119.594 122.899 GeneID:2664,Genbank:NM_001493.2,HGNC:HGNC:4226,MIM:300104 GDP dissociation inhibitor 1 GO:0005092,GO:0005093,GO:0005096,GO:0005737,GO:0005794,GO:0005829,GO:0007165,GO:0015031,GO:0017137,GO:0030424,GO:0030496,GO:0032482,GO:0043025,GO:0043209,GO:0043234,GO:0045773,GO:0050771,GO:0051056,GO:0051592,GO:0090315 GDP-dissociation inhibitor activity|Rab GDP-dissociation inhibitor activity|GTPase activator activity|cytoplasm|Golgi apparatus|cytosol|signal transduction|protein transport|Rab GTPase binding|axon|midbody|Rab protein signal transduction|neuronal cell body|myelin sheath|protein complex|positive regulation of axon extension|negative regulation of axonogenesis|regulation of small GTPase mediated signal transduction|response to calcium ion|negative regulation of protein targeting to membrane GDI2 5379.87710934272 5512.65061460053 5247.10360408492 0.951829522841099 -0.0712248917065707 0.601023014094909 1 48.3693 48.4886 47.9704 45.0207 GeneID:2665,Genbank:XM_017016071.2,HGNC:HGNC:4227,MIM:600767 GDP dissociation inhibitor 2 GO:0003723,GO:0005093,GO:0005096,GO:0005576,GO:0005737,GO:0005794,GO:0005829,GO:0005925,GO:0007165,GO:0007264,GO:0015031,GO:0016020,GO:0031267,GO:0031982,GO:0034774,GO:0035578,GO:0043209,GO:0043312,GO:0051056,GO:0070062 RNA binding|Rab GDP-dissociation inhibitor activity|GTPase activator activity|extracellular region|cytoplasm|Golgi apparatus|cytosol|focal adhesion|signal transduction|small GTPase mediated signal transduction|protein transport|membrane|small GTPase binding|vesicle|secretory granule lumen|azurophil granule lumen|myelin sheath|neutrophil degranulation|regulation of small GTPase mediated signal transduction|extracellular exosome GDPD1 56.7857625894995 53.964672144248 59.6068530347511 1.10455323207415 0.143462948615144 0.747947931137517 1 0.409743 0.538465 0.57442 0.546539 GeneID:284161,Genbank:NM_182569.3,HGNC:HGNC:20883,MIM:616317 glycerophosphodiester phosphodiesterase domain containing 1 GO:0004622,GO:0006644,GO:0016020,GO:0016021,GO:0046872,GO:0047391,GO:0048471,GO:0070291 lysophospholipase activity|phospholipid metabolic process|membrane|integral component of membrane|metal ion binding|alkylglycerophosphoethanolamine phosphodiesterase activity|perinuclear region of cytoplasm|N-acylethanolamine metabolic process hsa00565 Ether lipid metabolism GDPD2 6.18431346208537 5.58289052027075 6.7857364039 1.21545217110417 0.281493123421393 0.891837968181508 1 0.0362587 0.0645182 0.0676724 0.0473365 GeneID:54857,Genbank:NM_001171192.1,HGNC:HGNC:25974,MIM:300940 glycerophosphodiester phosphodiesterase domain containing 2 GO:0005737,GO:0005884,GO:0005886,GO:0006629,GO:0008889,GO:0016021,GO:0030027,GO:0045669,GO:0046872,GO:0047394,GO:0090527 cytoplasm|actin filament|plasma membrane|lipid metabolic process|glycerophosphodiester phosphodiesterase activity|integral component of membrane|lamellipodium|positive regulation of osteoblast differentiation|metal ion binding|glycerophosphoinositol inositolphosphodiesterase activity|actin filament reorganization GDPD3 4.5459118345357 7.63922867747008 1.45259499160132 0.190149431693984 -2.39479446774372 0.122559643591266 1 0.273618 0.202477 0 0.0794307 GeneID:79153,Genbank:NM_024307.2,HGNC:HGNC:28638,MIM:616318 glycerophosphodiester phosphodiesterase domain containing 3 GO:0005789,GO:0008081,GO:0016021,GO:0034638,GO:0046872,GO:0048471,GO:0070062 endoplasmic reticulum membrane|phosphoric diester hydrolase activity|integral component of membrane|phosphatidylcholine catabolic process|metal ion binding|perinuclear region of cytoplasm|extracellular exosome hsa00565 Ether lipid metabolism GDPD5 49.0814816089451 50.1881797526439 47.9747834652464 0.955898056109897 -0.0650713279229042 0.894385900329798 1 0.25506 0.221095 0.243206 0.227647 GeneID:81544,Genbank:XM_011545276.2,HGNC:HGNC:28804,MIM:609632 glycerophosphodiester phosphodiesterase domain containing 5 GO:0006629,GO:0008889,GO:0016021,GO:0021522,GO:0021895,GO:0030424,GO:0030426,GO:0031175,GO:0043025,GO:0045666,GO:0045746,GO:0045787,GO:0047389,GO:0048505,GO:0097038 lipid metabolic process|glycerophosphodiester phosphodiesterase activity|integral component of membrane|spinal cord motor neuron differentiation|cerebral cortex neuron differentiation|axon|growth cone|neuron projection development|neuronal cell body|positive regulation of neuron differentiation|negative regulation of Notch signaling pathway|positive regulation of cell cycle|glycerophosphocholine phosphodiesterase activity|regulation of timing of cell differentiation|perinuclear endoplasmic reticulum GDPGP1 47.7548253754798 51.4084539299833 44.1011968209762 0.857858843236963 -0.221187816528073 0.614523727775217 1 1.49682 1.21885 1.25051 1.27021 GeneID:390637,Genbank:NM_001322811.1,HGNC:HGNC:34360 GDP-D-glucose phosphorylase 1 GO:0000166,GO:0005085,GO:0005737,GO:0006006,GO:0016779,GO:0016787,GO:0080048 nucleotide binding|guanyl-nucleotide exchange factor activity|cytoplasm|glucose metabolic process|nucleotidyltransferase activity|hydrolase activity|GDP-D-glucose phosphorylase activity GEM 716.337326852357 679.995179497606 752.679474207109 1.10688942642682 0.146511110183335 0.367709184995782 1 9.63821 9.88024 12.2741 10.4541 GeneID:2669,Genbank:XM_017013315.1,HGNC:HGNC:4234,MIM:600164 GTP binding protein overexpressed in skeletal muscle GO:0000278,GO:0000287,GO:0003924,GO:0005516,GO:0005525,GO:0005634,GO:0006955,GO:0007165,GO:0007166,GO:0009898,GO:0019003,GO:0030496,GO:0051233,GO:0051276,GO:0051310,GO:0072686,GO:1901842 mitotic cell cycle|magnesium ion binding|GTPase activity|calmodulin binding|GTP binding|nucleus|immune response|signal transduction|cell surface receptor signaling pathway|cytoplasmic side of plasma membrane|GDP binding|midbody|spindle midzone|chromosome organization|metaphase plate congression|mitotic spindle|negative regulation of high voltage-gated calcium channel activity GEMIN2 186.031500948546 207.305943679653 164.757058217439 0.794753181182473 -0.331421208793701 0.158116758037506 1 5.72268 5.46573 4.4881 5.10492 GeneID:8487,Genbank:XM_017021709.1,HGNC:HGNC:10884,MIM:602595 gem nuclear organelle associated protein 2 GO:0000245,GO:0000375,GO:0000387,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005829,GO:0006397,GO:0008380,GO:0016604,GO:0032797,GO:0034719,GO:0051170,GO:0097504 spliceosomal complex assembly|RNA splicing, via transesterification reactions|spliceosomal snRNP assembly|nucleus|nucleoplasm|spliceosomal complex|nucleolus|cytosol|mRNA processing|RNA splicing|nuclear body|SMN complex|SMN-Sm protein complex|nuclear import|Gemini of coiled bodies hsa03013 RNA transport GEMIN4 2185.89183179225 2326.19297788761 2045.59068569689 0.879372736974933 -0.185453289242377 0.177662313918521 1 15.0497 16.0604 14.0001 13.6992 GeneID:50628,Genbank:NM_015721.2,HGNC:HGNC:15717,MIM:606969 gem nuclear organelle associated protein 4 GO:0000387,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0016020,GO:0016604,GO:0030532,GO:0032797,GO:0034719,GO:0051170,GO:0070062,GO:0097504 spliceosomal snRNP assembly|nucleoplasm|nucleolus|cytoplasm|cytosol|rRNA processing|membrane|nuclear body|small nuclear ribonucleoprotein complex|SMN complex|SMN-Sm protein complex|nuclear import|extracellular exosome|Gemini of coiled bodies hsa03013 RNA transport GEMIN5 1179.33680061244 1270.63570170641 1088.03789951847 0.856294135335002 -0.223821650247466 0.132308466010186 1 7.23827 7.51722 6.90956 5.88469 GeneID:25929,Genbank:NM_001252156.1,HGNC:HGNC:20043,MIM:607005 gem nuclear organelle associated protein 5 GO:0000340,GO:0000387,GO:0000398,GO:0003723,GO:0003730,GO:0005654,GO:0005737,GO:0005829,GO:0006412,GO:0006417,GO:0006461,GO:0016020,GO:0016604,GO:0017069,GO:0030619,GO:0030621,GO:0030622,GO:0032797,GO:0034718,GO:0034719,GO:0043022,GO:0051170,GO:0097504 RNA 7-methylguanosine cap binding|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|nucleoplasm|cytoplasm|cytosol|translation|regulation of translation|protein complex assembly|membrane|nuclear body|snRNA binding|U1 snRNA binding|U4 snRNA binding|U4atac snRNA binding|SMN complex|SMN-Gemin2 complex|SMN-Sm protein complex|ribosome binding|nuclear import|Gemini of coiled bodies hsa03013 RNA transport GEMIN6 369.441988636658 389.013521598792 349.870455674524 0.899378649453121 -0.152999458927699 0.415950399374758 1 17.8501 18.7949 15.9076 17.7319 GeneID:79833,Genbank:NM_024775.9,HGNC:HGNC:20044,MIM:607006 gem nuclear organelle associated protein 6 GO:0000245,GO:0000387,GO:0000398,GO:0005654,GO:0005737,GO:0005829,GO:0016604,GO:0032797,GO:0034719,GO:0051170,GO:0097504 spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|nucleoplasm|cytoplasm|cytosol|nuclear body|SMN complex|SMN-Sm protein complex|nuclear import|Gemini of coiled bodies hsa03013 RNA transport GEMIN7 490.8168808617 498.028869895681 483.604891827719 0.971037867601967 -0.042400537310533 0.834295994222463 1 7.79613 9.57322 7.97038 9.54782 GeneID:79760,Genbank:XM_005259263.5,HGNC:HGNC:20045,MIM:607419 gem nuclear organelle associated protein 7 GO:0000387,GO:0000398,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016604,GO:0032797,GO:0034719,GO:0051170,GO:0097504 spliceosomal snRNP assembly|mRNA splicing, via spliceosome|nucleus|nucleoplasm|cytoplasm|cytosol|nuclear body|SMN complex|SMN-Sm protein complex|nuclear import|Gemini of coiled bodies hsa03013 RNA transport GEMIN8 141.639122288281 151.938700914434 131.339543662128 0.864424553268318 -0.210188043542145 0.412859467816123 1 0.706218 0.818515 0.7403 0.569357 GeneID:54960,Genbank:XM_017029618.2,HGNC:HGNC:26044,MIM:300962 gem nuclear organelle associated protein 8 GO:0000387,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0032797,GO:0034719,GO:0051170,GO:0097504 spliceosomal snRNP assembly|nucleus|nucleoplasm|cytoplasm|cytosol|SMN complex|SMN-Sm protein complex|nuclear import|Gemini of coiled bodies hsa03013 RNA transport GEN1 136.06897094699 151.429012202261 120.70892969172 0.797132121092433 -0.327109230586845 0.476000658076778 1 0.831171 0.740654 0.863067 0.398078 GeneID:348654,Genbank:XM_011532822.2,HGNC:HGNC:26881,MIM:612449 GEN1, Holliday junction 5' flap endonuclease GO:0000724,GO:0003677,GO:0004520,GO:0005654,GO:0005813,GO:0008821,GO:0010824,GO:0046872,GO:0070062,GO:0071139,GO:0071140,GO:0090267 double-strand break repair via homologous recombination|DNA binding|endodeoxyribonuclease activity|nucleoplasm|centrosome|crossover junction endodeoxyribonuclease activity|regulation of centrosome duplication|metal ion binding|extracellular exosome|resolution of recombination intermediates|resolution of mitotic recombination intermediates|positive regulation of mitotic cell cycle spindle assembly checkpoint GET4 1411.22075352405 1362.78772558376 1459.65378146435 1.07107934277813 0.0990653551513861 0.512986077913562 1 36.11 36.4829 39.2081 40.3524 GeneID:51608,Genbank:NM_015949.2,HGNC:HGNC:21690,MIM:612056 golgi to ER traffic protein 4 GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0051087,GO:0051220,GO:0071816,GO:0071818,GO:1904378 nucleoplasm|nucleolus|cytoplasm|cytosol|chaperone binding|cytoplasmic sequestering of protein|tail-anchored membrane protein insertion into ER membrane|BAT3 complex|maintenance of unfolded protein involved in ERAD pathway GFAP 4189.98255868687 3529.99972348675 4849.96539388699 1.37392798124541 0.458306382741742 0.116652485427432 1 25.5819 27.333 32.0843 42.8613 GeneID:2670,Genbank:NM_002055.4,HGNC:HGNC:4235,MIM:137780 glial fibrillary acidic protein GO:0005198,GO:0005737,GO:0005882,GO:0045109 structural molecule activity|cytoplasm|intermediate filament|intermediate filament organization hsa04630 Jak-STAT signaling pathway GFER 732.912658119166 723.871282955452 741.95403328288 1.02498061568847 0.0355966259116409 0.858611892611626 1 10.8713 12.6152 12.1481 12.3853 GeneID:2671,Genbank:NM_005262.2,HGNC:HGNC:4236,MIM:600924 growth factor, augmenter of liver regeneration GO:0001889,GO:0005576,GO:0005739,GO:0005758,GO:0005829,GO:0008083,GO:0015035,GO:0016971,GO:0050660 liver development|extracellular region|mitochondrion|mitochondrial intermembrane space|cytosol|growth factor activity|protein disulfide oxidoreductase activity|flavin-linked sulfhydryl oxidase activity|flavin adenine dinucleotide binding GFI1 2.53303183867782 2.64246210852658 2.42360156882906 0.917175523920924 -0.124730239738681 1 1 0.0238453 0 0.0224113 0.0139565 GeneID:2672,Genbank:XM_011541246.2,HGNC:HGNC:4237,MIM:600871 growth factor independent 1 transcriptional repressor GFM1 855.947463816727 882.650349186218 829.244578447236 0.939493854176548 -0.0900443707918097 0.565825256518813 1 8.06588 8.72074 8.87035 7.23576 GeneID:85476,Genbank:XM_006713795.2,HGNC:HGNC:13780,MIM:606639 G elongation factor mitochondrial 1 GO:0003723,GO:0003746,GO:0003924,GO:0005525,GO:0005739,GO:0005759,GO:0070125 RNA binding|translation elongation factor activity|GTPase activity|GTP binding|mitochondrion|mitochondrial matrix|mitochondrial translational elongation GFM2 976.047501106473 1014.30300052081 937.792001692141 0.924567906444742 -0.113148810202983 0.477629049575818 1 6.47249 5.89474 6.38097 5.41672 GeneID:84340,Genbank:NM_170691.2,HGNC:HGNC:29682,MIM:606544 G elongation factor mitochondrial 2 GO:0003924,GO:0005525,GO:0005759,GO:0032543,GO:0032790,GO:0070126 GTPase activity|GTP binding|mitochondrial matrix|mitochondrial translation|ribosome disassembly|mitochondrial translational termination GFOD1 260.934088256229 287.762880494068 234.10529601839 0.813535420608969 -0.29772293396259 0.150318112797352 1 1.10611 1.20979 1.1191 0.807969 GeneID:54438,Genbank:XM_011514699.2,HGNC:HGNC:21096 glucose-fructose oxidoreductase domain containing 1 GO:0005576,GO:0016491 extracellular region|oxidoreductase activity GFOD2 786.096534919226 763.363118758441 808.829951080012 1.05956121170161 0.0834669357680725 0.596770805792494 1 4.37855 4.10065 4.60414 4.6452 GeneID:81577,Genbank:NM_030819.3,HGNC:HGNC:28159 glucose-fructose oxidoreductase domain containing 2 GO:0005578,GO:0016491,GO:0030198 proteinaceous extracellular matrix|oxidoreductase activity|extracellular matrix organization GFPT1 1136.86332473385 1100.34282785549 1173.38382161221 1.06638021524535 0.0927219191927463 0.525822776909808 1 4.82191 4.67646 5.76814 4.51236 GeneID:2673,Genbank:NM_002056.3,HGNC:HGNC:4241,MIM:138292 glutamine--fructose-6-phosphate transaminase 1 GO:0004360,GO:0005829,GO:0006002,GO:0006047,GO:0006048,GO:0006112,GO:0006487,GO:0006541,GO:0032922,GO:0036498,GO:0070062,GO:0097367 glutamine-fructose-6-phosphate transaminase (isomerizing) activity|cytosol|fructose 6-phosphate metabolic process|UDP-N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|energy reserve metabolic process|protein N-linked glycosylation|glutamine metabolic process|circadian regulation of gene expression|IRE1-mediated unfolded protein response|extracellular exosome|carbohydrate derivative binding hsa00250,hsa00520,hsa04931 Alanine, aspartate and glutamate metabolism|Amino sugar and nucleotide sugar metabolism|Insulin resistance GFPT2 2338.19037474987 2814.8428475612 1861.53790193854 0.661329247404127 -0.596559388456066 1.6672823060979e-05 0.00702715616170104 29.0481 29.9432 21.2315 18.6697 GeneID:9945,Genbank:NM_005110.3,HGNC:HGNC:4242,MIM:603865 glutamine-fructose-6-phosphate transaminase 2 GO:0004360,GO:0005829,GO:0006002,GO:0006047,GO:0006048,GO:0006112,GO:0006487,GO:0006541,GO:0097367,GO:1990830 glutamine-fructose-6-phosphate transaminase (isomerizing) activity|cytosol|fructose 6-phosphate metabolic process|UDP-N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|energy reserve metabolic process|protein N-linked glycosylation|glutamine metabolic process|carbohydrate derivative binding|cellular response to leukemia inhibitory factor hsa00250,hsa00520,hsa04931 Alanine, aspartate and glutamate metabolism|Amino sugar and nucleotide sugar metabolism|Insulin resistance GFRA1 4093.18153037732 4417.15269983653 3769.21036091811 0.853312216500371 -0.22885439228551 0.0876038807179133 0.970036792388817 16.3805 16.7367 15.7702 12.5725 GeneID:2674,Genbank:NM_001145453.2,HGNC:HGNC:4243,MIM:601496 GDNF family receptor alpha 1 GO:0000165,GO:0005088,GO:0005102,GO:0005622,GO:0005886,GO:0007166,GO:0007411,GO:0016167,GO:0019898,GO:0031225,GO:0070062 MAPK cascade|Ras guanyl-nucleotide exchange factor activity|receptor binding|intracellular|plasma membrane|cell surface receptor signaling pathway|axon guidance|glial cell-derived neurotrophic factor receptor activity|extrinsic component of membrane|anchored component of membrane|extracellular exosome GFRA2 1.48541773607917 1.51824048055703 1.45259499160132 0.956762127083039 -0.0637678125324669 1 1 0.00987663 0.0174952 0 0.0257997 GeneID:2675,Genbank:XM_006716327.3,HGNC:HGNC:4244,MIM:601956 GDNF family receptor alpha 2 GO:0000165,GO:0005088,GO:0005622,GO:0005886,GO:0007169,GO:0007411,GO:0016167,GO:0019898,GO:0031225,GO:0033141 MAPK cascade|Ras guanyl-nucleotide exchange factor activity|intracellular|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|axon guidance|glial cell-derived neurotrophic factor receptor activity|extrinsic component of membrane|anchored component of membrane|positive regulation of peptidyl-serine phosphorylation of STAT protein GFRA3 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.024106 0.025699 0.0239541 GeneID:2676,Genbank:NM_001496.3,HGNC:HGNC:4245,MIM:605710 GDNF family receptor alpha 3 GO:0000165,GO:0001764,GO:0005088,GO:0005102,GO:0005829,GO:0005886,GO:0007165,GO:0007399,GO:0007411,GO:0007422,GO:0008046,GO:0009897,GO:0019898,GO:0031225,GO:0048485 MAPK cascade|neuron migration|Ras guanyl-nucleotide exchange factor activity|receptor binding|cytosol|plasma membrane|signal transduction|nervous system development|axon guidance|peripheral nervous system development|axon guidance receptor activity|external side of plasma membrane|extrinsic component of membrane|anchored component of membrane|sympathetic nervous system development GFY 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0312665 0 GeneID:100507003,Genbank:XM_011526299.2,HGNC:HGNC:44663 golgi associated olfactory signaling regulator GO:0007608,GO:0030173,GO:0050896,GO:0097499,GO:1905515 sensory perception of smell|integral component of Golgi membrane|response to stimulus|protein localization to non-motile cilium|non-motile cilium assembly GGA1 763.512416894018 732.297532337242 794.727301450795 1.08525191791142 0.11802997219582 0.466866653875132 1 3.45247 3.52017 3.77405 3.99767 GeneID:26088,Genbank:XM_024452213.1,HGNC:HGNC:17842,MIM:606004 golgi associated, gamma adaptin ear containing, ARF binding protein 1 GO:0005654,GO:0005794,GO:0006886,GO:0010008,GO:0016020,GO:0016192,GO:0030131,GO:0030306,GO:0031901,GO:0043231,GO:0043234,GO:0044267,GO:0045732,GO:0046982,GO:1901998 nucleoplasm|Golgi apparatus|intracellular protein transport|endosome membrane|membrane|vesicle-mediated transport|clathrin adaptor complex|ADP-ribosylation factor binding|early endosome membrane|intracellular membrane-bounded organelle|protein complex|cellular protein metabolic process|positive regulation of protein catabolic process|protein heterodimerization activity|toxin transport hsa04142 Lysosome GGA2 1411.43698909607 1388.39589999938 1434.47807819275 1.03319094949315 0.0471069109586599 0.766608681740628 1 7.46887 8.22607 8.28033 8.38089 GeneID:23062,Genbank:NM_015044.4,HGNC:HGNC:16064,MIM:606005 golgi associated, gamma adaptin ear containing, ARF binding protein 2 GO:0005794,GO:0005802,GO:0006886,GO:0010008,GO:0016192,GO:0030131,GO:0030136,GO:0030306,GO:0031901,GO:0044267 Golgi apparatus|trans-Golgi network|intracellular protein transport|endosome membrane|vesicle-mediated transport|clathrin adaptor complex|clathrin-coated vesicle|ADP-ribosylation factor binding|early endosome membrane|cellular protein metabolic process hsa04142 Lysosome GGA3 1220.21179317071 1262.27607890867 1178.14750743275 0.933351686781028 -0.0995073040855912 0.498018983075475 1 8.57868 8.57809 8.42028 7.84818 GeneID:23163,Genbank:XM_011524563.3,HGNC:HGNC:17079,MIM:606006 golgi associated, gamma adaptin ear containing, ARF binding protein 3 GO:0005794,GO:0005802,GO:0006886,GO:0010008,GO:0016192,GO:0030131,GO:0030306,GO:0031901,GO:0044267,GO:0045732,GO:0055038 Golgi apparatus|trans-Golgi network|intracellular protein transport|endosome membrane|vesicle-mediated transport|clathrin adaptor complex|ADP-ribosylation factor binding|early endosome membrane|cellular protein metabolic process|positive regulation of protein catabolic process|recycling endosome membrane hsa04142 Lysosome GGACT 98.3757195268929 98.8581190247307 97.893320029055 0.990240568956867 -0.0141490389078845 0.975695806658578 1 0.464093 0.514262 0.562716 0.525228 GeneID:87769,Genbank:NM_001195087.1,HGNC:HGNC:25100,MIM:613378 gamma-glutamylamine cyclotransferase GO:0003839,GO:0016829,GO:0042219,GO:0070062 gamma-glutamylcyclotransferase activity|lyase activity|cellular modified amino acid catabolic process|extracellular exosome GGCT 1539.81106478201 1683.40093931576 1396.22119024826 0.829405020301209 -0.269851315135967 0.064934959794816 0.901211712368954 36.2884 34.9435 30.789 28.784 GeneID:79017,Genbank:NM_001199817.1,HGNC:HGNC:21705,MIM:137170 gamma-glutamylcyclotransferase GO:0001836,GO:0003839,GO:0005829,GO:0006750,GO:0016829,GO:0042803,GO:0070062 release of cytochrome c from mitochondria|gamma-glutamylcyclotransferase activity|cytosol|glutathione biosynthetic process|lyase activity|protein homodimerization activity|extracellular exosome hsa00480 Glutathione metabolism GGCX 1551.06055486625 1500.44671225653 1601.67439747598 1.0674650318419 0.0941888106283681 0.523541094673454 1 7.16747 7.6852 8.05011 7.83321 GeneID:2677,Genbank:NM_001142269.3,HGNC:HGNC:4247,MIM:137167 gamma-glutamyl carboxylase GO:0005789,GO:0006464,GO:0007596,GO:0008488,GO:0016020,GO:0016021,GO:0017187 endoplasmic reticulum membrane|cellular protein modification process|blood coagulation|gamma-glutamyl carboxylase activity|membrane|integral component of membrane|peptidyl-glutamic acid carboxylation hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis GGH 3154.70541779634 3382.30390105224 2927.10693454044 0.865418076013162 -0.20853084019851 0.126128931365292 1 40.3393 41.6328 35.8475 34.8507 GeneID:8836,Genbank:NM_003878.2,HGNC:HGNC:4248,MIM:601509 gamma-glutamyl hydrolase hsa00790,hsa01523 Folate biosynthesis|Antifolate resistance GGN 24.843553350382 28.8465691305835 20.8405375701804 0.722461568162189 -0.469007250383423 0.400826855854518 1 0.410294 0.700634 0.460598 0.370008 GeneID:199720,Genbank:XM_011526603.2,HGNC:HGNC:18869,MIM:609966 gametogenetin GO:0006302,GO:0007275,GO:0007276,GO:0007283,GO:0030154 double-strand break repair|multicellular organism development|gamete generation|spermatogenesis|cell differentiation GGNBP2 806.718745352068 842.38805898656 771.049431717577 0.915313819435181 -0.127661632232707 0.424932391116798 1 9.97616 9.79638 9.61929 8.72724 GeneID:79893,Genbank:NM_024835.4,HGNC:HGNC:19357,MIM:612275 gametogenetin binding protein 2 GO:0005634,GO:0005737,GO:0007283,GO:0008285,GO:0010629,GO:0030154,GO:0031410,GO:0033140,GO:0042532,GO:0060716,GO:0061099 nucleus|cytoplasm|spermatogenesis|negative regulation of cell proliferation|negative regulation of gene expression|cell differentiation|cytoplasmic vesicle|negative regulation of peptidyl-serine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|labyrinthine layer blood vessel development|negative regulation of protein tyrosine kinase activity GGPS1 396.909813287384 429.841301438707 363.978325136062 0.846773736999686 -0.239951570567704 0.281245075935176 1 6.22158 4.98007 5.43094 4.47832 GeneID:9453,Genbank:NM_001037277.1,HGNC:HGNC:4249,MIM:606982 geranylgeranyl diphosphate synthase 1 GO:0004161,GO:0004311,GO:0004337,GO:0005829,GO:0006695,GO:0006720,GO:0033384,GO:0033386,GO:0042802,GO:0045337,GO:0045540,GO:0046872 dimethylallyltranstransferase activity|farnesyltranstransferase activity|geranyltranstransferase activity|cytosol|cholesterol biosynthetic process|isoprenoid metabolic process|geranyl diphosphate biosynthetic process|geranylgeranyl diphosphate biosynthetic process|identical protein binding|farnesyl diphosphate biosynthetic process|regulation of cholesterol biosynthetic process|metal ion binding hsa00900 Terpenoid backbone biosynthesis GGT1 54.8554955778912 55.9249577520774 53.7860334037051 0.961753670734013 -0.0562606640076336 0.88187533213526 1 0.456789 0.773425 0.43754 0.661598 GeneID:2678,Genbank:NM_013430.2,HGNC:HGNC:4250,MIM:612346 gamma-glutamyltransferase 1 hsa00430,hsa00480,hsa00590 Taurine and hypotaurine metabolism|Glutathione metabolism|Arachidonic acid metabolism GGT5 1.76077463185061 3.03648096111406 0.48506830258717 0.159746861185391 -2.64614051048666 0.397050141148617 1 0 0.0158519 0.0171338 0 GeneID:2687,Genbank:NM_001302465.1,HGNC:HGNC:4260,MIM:137168 gamma-glutamyltransferase 5 GO:0000048,GO:0002951,GO:0005886,GO:0006508,GO:0006520,GO:0006631,GO:0006691,GO:0006750,GO:0006751,GO:0006954,GO:0016021,GO:0031226,GO:0036374,GO:0102953,GO:0103068,GO:1901750 peptidyltransferase activity|leukotriene-C(4) hydrolase|plasma membrane|proteolysis|cellular amino acid metabolic process|fatty acid metabolic process|leukotriene metabolic process|glutathione biosynthetic process|glutathione catabolic process|inflammatory response|integral component of membrane|intrinsic component of plasma membrane|glutathione hydrolase activity|hypoglycin A gamma-glutamyl transpeptidase activity|leukotriene C4 gamma-glutamyl transferase activity|leukotriene D4 biosynthetic process hsa00430,hsa00480,hsa00590 Taurine and hypotaurine metabolism|Glutathione metabolism|Arachidonic acid metabolism GGT7 611.108988329446 612.569273783047 609.648702875845 0.995232260199462 -0.0068948440697148 0.944115213149602 1 4.59238 5.42057 4.87873 5.19056 GeneID:2686,Genbank:NM_001351702.1,HGNC:HGNC:4259,MIM:612342 gamma-glutamyltransferase 7 GO:0005886,GO:0006750,GO:0006751,GO:0016021,GO:0036374,GO:0102953,GO:0103068,GO:1901750,GO:1902883 plasma membrane|glutathione biosynthetic process|glutathione catabolic process|integral component of membrane|glutathione hydrolase activity|hypoglycin A gamma-glutamyl transpeptidase activity|leukotriene C4 gamma-glutamyl transferase activity|leukotriene D4 biosynthetic process|negative regulation of response to oxidative stress hsa00430,hsa00480 Taurine and hypotaurine metabolism|Glutathione metabolism GHDC 307.307449715417 295.277647657699 319.337251773135 1.08148129161245 0.1130087085441 0.690031661829093 1 4.40254 5.54391 4.72565 5.81633 GeneID:84514,Genbank:NM_032484.4,HGNC:HGNC:24438,MIM:608587 GH3 domain containing GO:0005576,GO:0005635,GO:0005783,GO:0016020,GO:0034774,GO:0035580,GO:0043312 extracellular region|nuclear envelope|endoplasmic reticulum|membrane|secretory granule lumen|specific granule lumen|neutrophil degranulation GHITM 7005.30119088669 6837.41671858717 7173.18566318621 1.04910757357911 0.069162616820886 0.598153153864367 1 136.104 142.282 144.207 149.806 GeneID:27069,Genbank:NM_014394.2,HGNC:HGNC:17281 growth hormone inducible transmembrane protein GO:0005739,GO:0005743,GO:0006915,GO:0016021,GO:0070062 mitochondrion|mitochondrial inner membrane|apoptotic process|integral component of membrane|extracellular exosome GHR 110.631072746275 96.7057283181615 124.556417174388 1.2879941999361 0.365126096758223 0.207887715473854 1 0.55763 0.664012 0.844343 0.695777 GeneID:2690,Genbank:NM_000163.4,HGNC:HGNC:4263,MIM:600946 growth hormone receptor GO:0000187,GO:0000255,GO:0004896,GO:0005576,GO:0005615,GO:0005829,GO:0005886,GO:0005887,GO:0006101,GO:0006103,GO:0006105,GO:0006107,GO:0006549,GO:0006573,GO:0006600,GO:0006631,GO:0006897,GO:0007259,GO:0009986,GO:0016021,GO:0017046,GO:0019530,GO:0019838,GO:0019901,GO:0031623,GO:0032355,GO:0032870,GO:0036464,GO:0040014,GO:0040018,GO:0042531,GO:0042802,GO:0042803,GO:0042976,GO:0043235,GO:0044236,GO:0046449,GO:0046898,GO:0048009,GO:0050731,GO:0060396,GO:0060397,GO:0070064,GO:0070195 activation of MAPK activity|allantoin metabolic process|cytokine receptor activity|extracellular region|extracellular space|cytosol|plasma membrane|integral component of plasma membrane|citrate metabolic process|2-oxoglutarate metabolic process|succinate metabolic process|oxaloacetate metabolic process|isoleucine metabolic process|valine metabolic process|creatine metabolic process|fatty acid metabolic process|endocytosis|JAK-STAT cascade|cell surface|integral component of membrane|peptide hormone binding|taurine metabolic process|growth factor binding|protein kinase binding|receptor internalization|response to estradiol|cellular response to hormone stimulus|cytoplasmic ribonucleoprotein granule|regulation of multicellular organism growth|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|protein homodimerization activity|activation of Janus kinase activity|receptor complex|multicellular organism metabolic process|creatinine metabolic process|response to cycloheximide|insulin-like growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|growth hormone receptor signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|proline-rich region binding|growth hormone receptor complex hsa04060,hsa04080,hsa04151,hsa04630 Cytokine-cytokine receptor interaction|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Jak-STAT signaling pathway GHRL 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.015815 0 0 0 GeneID:51738,Genbank:NM_001134946.1,HGNC:HGNC:18129,MIM:605353 ghrelin and obestatin prepropeptide hsa04024 cAMP signaling pathway GID4 241.392782986874 262.759430339134 220.026135634614 0.837367227317529 -0.256067639564941 0.245076400777141 1 2.11976 1.87027 1.63266 1.52697 GeneID:79018,Genbank:NM_024052.4,HGNC:HGNC:28453,MIM:617699 GID complex subunit 4 homolog GO:0043161,GO:0061630 proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity GID8 1482.87790198088 1492.48009131051 1473.27571265125 0.987132572976297 -0.0186842416833876 0.898507473325349 1 16.6168 16.7549 17.0598 15.9913 GeneID:54994,Genbank:NM_017896.2,HGNC:HGNC:15857,MIM:611625 GID complex subunit 8 homolog GO:0005654,GO:0030054 nucleoplasm|cell junction GIGYF1 1202.31778700809 1225.50314045336 1179.13243356283 0.962161902846389 -0.0556484183758787 0.688835473148164 1 5.72136 6.25835 6.03953 5.59488 GeneID:64599,Genbank:NM_022574.5,HGNC:HGNC:9126,MIM:612064 GRB10 interacting GYF protein 1 GO:0043234,GO:0048009 protein complex|insulin-like growth factor receptor signaling pathway GIGYF2 1145.93504412485 1233.38046650254 1058.48962174717 0.858202031323466 -0.220610779006351 0.144341324352407 1 4.68785 4.61438 4.29498 3.68766 GeneID:26058,Genbank:NM_015575.3,HGNC:HGNC:11960,MIM:612003 GRB10 interacting GYF protein 2 GO:0003723,GO:0005768,GO:0005783,GO:0005794,GO:0005829,GO:0007631,GO:0008344,GO:0009791,GO:0010494,GO:0016020,GO:0016021,GO:0016441,GO:0017148,GO:0021522,GO:0031571,GO:0035264,GO:0043204,GO:0043234,GO:0044267,GO:0045296,GO:0048009,GO:0048873,GO:0050881,GO:0050885,GO:0061157,GO:0070064,GO:1990635 RNA binding|endosome|endoplasmic reticulum|Golgi apparatus|cytosol|feeding behavior|adult locomotory behavior|post-embryonic development|cytoplasmic stress granule|membrane|integral component of membrane|posttranscriptional gene silencing|negative regulation of translation|spinal cord motor neuron differentiation|mitotic G1 DNA damage checkpoint|multicellular organism growth|perikaryon|protein complex|cellular protein metabolic process|cadherin binding|insulin-like growth factor receptor signaling pathway|homeostasis of number of cells within a tissue|musculoskeletal movement|neuromuscular process controlling balance|mRNA destabilization|proline-rich region binding|proximal dendrite GIMAP6 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:474344,Genbank:NM_001244071.1,HGNC:HGNC:21918,MIM:616960 GTPase, IMAP family member 6 GO:0005525,GO:0005654,GO:0005829 GTP binding|nucleoplasm|cytosol GIN1 51.3204491124508 47.3918301649545 55.2490680599471 1.16579308854805 0.221311753705922 0.584742791983984 1 0.326359 0.25653 0.388232 0.250384 GeneID:54826,Genbank:XM_005272028.3,HGNC:HGNC:25959 gypsy retrotransposon integrase 1 GO:0003676,GO:0015074 nucleic acid binding|DNA integration GINM1 1300.55589520623 1281.38784658415 1319.7239438283 1.02991763761951 0.0425289698852716 0.772211146136345 1 25.2878 26.159 29.4535 24.7 GeneID:116254,Genbank:NM_138785.4,HGNC:HGNC:21074 glycoprotein integral membrane 1 GO:0016021,GO:0070062 integral component of membrane|extracellular exosome GINS1 814.380966798232 837.372692108256 791.389241488209 0.945086039879956 -0.0814824177677871 0.602023379008168 1 9.50718 10.3318 9.61025 9.33271 GeneID:9837,Genbank:NM_021067.4,HGNC:HGNC:28980,MIM:610608 GINS complex subunit 1 GO:0000811,GO:0001833,GO:0005634,GO:0005654,GO:0005737,GO:0006271,GO:0043138,GO:1902983 GINS complex|inner cell mass cell proliferation|nucleus|nucleoplasm|cytoplasm|DNA strand elongation involved in DNA replication|3'-5' DNA helicase activity|DNA strand elongation involved in mitotic DNA replication GINS2 1236.7836181835 1233.91958118004 1239.64765518696 1.00464217773531 0.00668174983394332 0.971887324668266 1 35.3122 36.5959 36.1627 36.2821 GeneID:51659,Genbank:NM_016095.2,HGNC:HGNC:24575,MIM:610609 GINS complex subunit 2 GO:0000727,GO:0000811,GO:0005654,GO:0006271,GO:0031298,GO:0032508,GO:1902975 double-strand break repair via break-induced replication|GINS complex|nucleoplasm|DNA strand elongation involved in DNA replication|replication fork protection complex|DNA duplex unwinding|mitotic DNA replication initiation GINS3 1013.25431806044 999.083395096513 1027.42524102436 1.02836784803646 0.0403564100688517 0.795351699264019 1 14.8264 15.7681 16.8416 15.6798 GeneID:64785,Genbank:NM_001126129.1,HGNC:HGNC:25851,MIM:610610 GINS complex subunit 3 GO:0005654,GO:0006271 nucleoplasm|DNA strand elongation involved in DNA replication GINS4 1786.94549624002 1743.95908775038 1829.93190472967 1.04929749647407 0.0694237683243513 0.628918242255453 1 16.9666 17.544 18.6249 18.2646 GeneID:84296,Genbank:XM_005273659.4,HGNC:HGNC:28226,MIM:610611 GINS complex subunit 4 GO:0000727,GO:0000811,GO:0001833,GO:0005654,GO:0005737,GO:0006270,GO:0006271,GO:0031298,GO:0032508 double-strand break repair via break-induced replication|GINS complex|inner cell mass cell proliferation|nucleoplasm|cytoplasm|DNA replication initiation|DNA strand elongation involved in DNA replication|replication fork protection complex|DNA duplex unwinding GIP 1.48878925781767 2.00831188251439 0.969266633120943 0.482627544835033 -1.05101783854861 0.812641228941161 1 0 0.0565269 0.058383 0 GeneID:2695,Genbank:NM_004123.2,HGNC:HGNC:4270,MIM:137240 gastric inhibitory polypeptide GO:0005179,GO:0005576,GO:0005615,GO:0005788,GO:0007165,GO:0007186,GO:0007565,GO:0007613,GO:0008344,GO:0009749,GO:0010269,GO:0010447,GO:0010828,GO:0014070,GO:0019233,GO:0031018,GO:0032024,GO:0033993,GO:0034774,GO:0035640,GO:0042493,GO:0042594,GO:0043025,GO:0043200,GO:0043434,GO:0043950,GO:0048678,GO:0050796,GO:0055123,GO:0060291,GO:0070094,GO:0070328 hormone activity|extracellular region|extracellular space|endoplasmic reticulum lumen|signal transduction|G-protein coupled receptor signaling pathway|female pregnancy|memory|adult locomotory behavior|response to glucose|response to selenium ion|response to acidic pH|positive regulation of glucose transport|response to organic cyclic compound|sensory perception of pain|endocrine pancreas development|positive regulation of insulin secretion|response to lipid|secretory granule lumen|exploration behavior|response to drug|response to starvation|neuronal cell body|response to amino acid|response to peptide hormone|positive regulation of cAMP-mediated signaling|response to axon injury|regulation of insulin secretion|digestive system development|long-term synaptic potentiation|positive regulation of glucagon secretion|triglyceride homeostasis hsa04911 Insulin secretion GIPC1 4787.45732195897 4570.84504895411 5004.06959496384 1.0947799676799 0.1306409415754 0.34129006784274 1 87.683 90.5724 97.2838 101.597 GeneID:10755,Genbank:NM_202494.2,HGNC:HGNC:1226,MIM:605072 GIPC PDZ domain containing family member 1 GO:0003779,GO:0005102,GO:0005737,GO:0005829,GO:0005903,GO:0005938,GO:0006605,GO:0007186,GO:0007268,GO:0008021,GO:0012506,GO:0014047,GO:0016020,GO:0017022,GO:0030139,GO:0030165,GO:0030511,GO:0031410,GO:0031647,GO:0032435,GO:0032467,GO:0042803,GO:0043197,GO:0043198,GO:0043542,GO:0045296,GO:0048167,GO:0070062 actin binding|receptor binding|cytoplasm|cytosol|brush border|cell cortex|protein targeting|G-protein coupled receptor signaling pathway|chemical synaptic transmission|synaptic vesicle|vesicle membrane|glutamate secretion|membrane|myosin binding|endocytic vesicle|PDZ domain binding|positive regulation of transforming growth factor beta receptor signaling pathway|cytoplasmic vesicle|regulation of protein stability|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of cytokinesis|protein homodimerization activity|dendritic spine|dendritic shaft|endothelial cell migration|cadherin binding|regulation of synaptic plasticity|extracellular exosome GIPC2 0.974269732491135 0.980142803914724 0.968396661067546 0.988015886256305 -0.0173938558720137 1 1 0 0.0133077 0 0.0245895 GeneID:54810,Genbank:NM_001304725.1,HGNC:HGNC:18177 GIPC PDZ domain containing family member 2 GO:0005737,GO:0042802,GO:0070062 cytoplasm|identical protein binding|extracellular exosome GIPC3 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0143219 0 GeneID:126326,Genbank:XM_005259492.3,HGNC:HGNC:18183,MIM:608792 GIPC PDZ domain containing family member 3 GIPR 40.8811333622136 38.1383084575575 43.6239582668696 1.14383568729633 0.193879822965652 0.67278543188622 1 0.318618 0.261849 0.459858 0.311078 GeneID:2696,Genbank:XM_011526710.2,HGNC:HGNC:4271,MIM:137241 gastric inhibitory polypeptide receptor GO:0002029,GO:0004888,GO:0005886,GO:0006091,GO:0007166,GO:0007186,GO:0007190,GO:0007204,GO:0007584,GO:0009749,GO:0016021,GO:0016519,GO:0017046,GO:0031018,GO:0032024,GO:0043950,GO:0048678,GO:0050796,GO:0051592,GO:0070542 desensitization of G-protein coupled receptor protein signaling pathway|transmembrane signaling receptor activity|plasma membrane|generation of precursor metabolites and energy|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|positive regulation of cytosolic calcium ion concentration|response to nutrient|response to glucose|integral component of membrane|gastric inhibitory peptide receptor activity|peptide hormone binding|endocrine pancreas development|positive regulation of insulin secretion|positive regulation of cAMP-mediated signaling|response to axon injury|regulation of insulin secretion|response to calcium ion|response to fatty acid hsa04024,hsa04080 cAMP signaling pathway|Neuroactive ligand-receptor interaction GIT1 2383.09661790805 2287.33427530977 2478.85896050633 1.08373270460026 0.116008969514889 0.416346648048529 1 18.6419 19.7087 21.6291 21.2691 GeneID:28964,Genbank:NM_014030.3,HGNC:HGNC:4272,MIM:608434 GIT ArfGAP 1 GO:0005096,GO:0005829,GO:0005925,GO:0008277,GO:0016020,GO:0032403,GO:0032465,GO:0046872,GO:0048013 GTPase activator activity|cytosol|focal adhesion|regulation of G-protein coupled receptor protein signaling pathway|membrane|protein complex binding|regulation of cytokinesis|metal ion binding|ephrin receptor signaling pathway hsa04144,hsa04810,hsa05120 Endocytosis|Regulation of actin cytoskeleton|Epithelial cell signaling in Helicobacter pylori infection GIT2 715.219750105717 754.339919769361 676.099580442074 0.89627973109098 -0.157979023682478 0.337291244545092 1 3.87481 3.51865 3.73612 3.07712 GeneID:9815,Genbank:NM_001330153.1,HGNC:HGNC:4273,MIM:608564 GIT ArfGAP 2 GO:0005096,GO:0005654,GO:0005925,GO:0008277,GO:0046872 GTPase activator activity|nucleoplasm|focal adhesion|regulation of G-protein coupled receptor protein signaling pathway|metal ion binding hsa04144 Endocytosis GJA1 1156.55039476914 1300.62305877262 1012.47773076566 0.77845592843873 -0.361312730114415 0.0669045948376977 0.912266462842959 19.6039 17.4044 16.2144 12.9153 GeneID:2697,Genbank:NM_000165.4,HGNC:HGNC:4274,MIM:121014 gap junction protein alpha 1 GO:0000139,GO:0001649,GO:0001701,GO:0001764,GO:0001937,GO:0001947,GO:0002070,GO:0002088,GO:0002544,GO:0002931,GO:0003104,GO:0003158,GO:0003294,GO:0004871,GO:0005102,GO:0005243,GO:0005654,GO:0005739,GO:0005741,GO:0005764,GO:0005769,GO:0005771,GO:0005789,GO:0005794,GO:0005829,GO:0005882,GO:0005886,GO:0005887,GO:0005916,GO:0005921,GO:0005922,GO:0005925,GO:0006810,GO:0006915,GO:0006936,GO:0007165,GO:0007204,GO:0007267,GO:0007507,GO:0007512,GO:0009749,GO:0010232,GO:0010628,GO:0010629,GO:0010643,GO:0010644,GO:0010652,GO:0014704,GO:0015075,GO:0015867,GO:0016264,GO:0016324,GO:0016328,GO:0017124,GO:0022898,GO:0030054,GO:0030165,GO:0030308,GO:0030500,GO:0030660,GO:0032024,GO:0032496,GO:0032526,GO:0034220,GO:0034405,GO:0042733,GO:0043123,GO:0043231,GO:0043292,GO:0043403,GO:0043434,GO:0045121,GO:0045669,GO:0045732,GO:0045844,GO:0045907,GO:0046697,GO:0046850,GO:0048487,GO:0048514,GO:0048812,GO:0051259,GO:0051924,GO:0060044,GO:0060156,GO:0060307,GO:0060371,GO:0060373,GO:0061045,GO:0070062,GO:0071253,GO:0071260,GO:0071374,GO:0071467,GO:0086014,GO:0086064,GO:0086075,GO:0097110,GO:0097718,GO:0097755,GO:1903763,GO:1905867,GO:1990782,GO:2000279,GO:2000810,GO:2000987 Golgi membrane|osteoblast differentiation|in utero embryonic development|neuron migration|negative regulation of endothelial cell proliferation|heart looping|epithelial cell maturation|lens development in camera-type eye|chronic inflammatory response|response to ischemia|positive regulation of glomerular filtration|endothelium development|atrial ventricular junction remodeling|signal transducer activity|receptor binding|gap junction channel activity|nucleoplasm|mitochondrion|mitochondrial outer membrane|lysosome|early endosome|multivesicular body|endoplasmic reticulum membrane|Golgi apparatus|cytosol|intermediate filament|plasma membrane|integral component of plasma membrane|fascia adherens|gap junction|connexin complex|focal adhesion|transport|apoptotic process|muscle contraction|signal transduction|positive regulation of cytosolic calcium ion concentration|cell-cell signaling|heart development|adult heart development|response to glucose|vascular transport|positive regulation of gene expression|negative regulation of gene expression|cell communication by chemical coupling|cell communication by electrical coupling|positive regulation of cell communication by chemical coupling|intercalated disc|ion transmembrane transporter activity|ATP transport|gap junction assembly|apical plasma membrane|lateral plasma membrane|SH3 domain binding|regulation of transmembrane transporter activity|cell junction|PDZ domain binding|negative regulation of cell growth|regulation of bone mineralization|Golgi-associated vesicle membrane|positive regulation of insulin secretion|response to lipopolysaccharide|response to retinoic acid|ion transmembrane transport|response to fluid shear stress|embryonic digit morphogenesis|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|contractile fiber|skeletal muscle tissue regeneration|response to peptide hormone|membrane raft|positive regulation of osteoblast differentiation|positive regulation of protein catabolic process|positive regulation of striated muscle tissue development|positive regulation of vasoconstriction|decidualization|regulation of bone remodeling|beta-tubulin binding|blood vessel morphogenesis|neuron projection morphogenesis|protein oligomerization|regulation of calcium ion transport|negative regulation of cardiac muscle cell proliferation|milk ejection reflex|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane depolarization|regulation of ventricular cardiac muscle cell membrane depolarization|negative regulation of wound healing|extracellular exosome|connexin binding|cellular response to mechanical stimulus|cellular response to parathyroid hormone stimulus|cellular response to pH|atrial cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|gap junction channel activity involved in cardiac conduction electrical coupling|scaffold protein binding|disordered domain specific binding|positive regulation of blood vessel diameter|gap junction channel activity involved in cell communication by electrical coupling|epididymis development|protein tyrosine kinase binding|negative regulation of DNA biosynthetic process|regulation of bicellular tight junction assembly|positive regulation of behavioral fear response hsa04540,hsa05412 Gap junction|Arrhythmogenic right ventricular cardiomyopathy (ARVC) GJA3 3.42819249611295 2.00831188251439 4.84807310971151 2.41400409563965 1.2714281237955 0.512554733487884 1 0.0106836 0.0297399 0.0707951 0.0283589 GeneID:2700,Genbank:XM_011535048.2,HGNC:HGNC:4277,MIM:121015 gap junction protein alpha 3 GO:0005243,GO:0005922,GO:0006810,GO:0007267,GO:0007601,GO:0016021 gap junction channel activity|connexin complex|transport|cell-cell signaling|visual perception|integral component of membrane GJA5 1.50943087342164 1.56626675524197 1.45259499160132 0.927425029446474 -0.108697432040536 1 1 0.0135824 0.0063061 0 0.0180497 GeneID:2702,Genbank:XM_005272951.4,HGNC:HGNC:4279,MIM:121013 gap junction protein alpha 5 GO:0001501,GO:0001525,GO:0003105,GO:0003151,GO:0003158,GO:0003161,GO:0003174,GO:0003193,GO:0003281,GO:0003283,GO:0003284,GO:0003294,GO:0005887,GO:0005921,GO:0005922,GO:0006813,GO:0010643,GO:0010652,GO:0014704,GO:0016264,GO:0030326,GO:0035050,GO:0035922,GO:0042995,GO:0045776,GO:0045907,GO:0048844,GO:0051259,GO:0055077,GO:0055117,GO:0060307,GO:0060371,GO:0060373,GO:0060412,GO:0060413,GO:0071253,GO:0086005,GO:0086015,GO:0086020,GO:0086021,GO:0086044,GO:0086053,GO:0086054,GO:0086055,GO:0086064,GO:0086075,GO:0086076,GO:0086077,GO:0086078,GO:0086079,GO:0086091,GO:0097718,GO:0097755,GO:0098904,GO:0098905,GO:0098906,GO:0098910,GO:1900133,GO:1900825,GO:1990029 skeletal system development|angiogenesis|negative regulation of glomerular filtration|outflow tract morphogenesis|endothelium development|cardiac conduction system development|mitral valve development|pulmonary valve formation|ventricular septum development|atrial septum development|septum primum development|atrial ventricular junction remodeling|integral component of plasma membrane|gap junction|connexin complex|potassium ion transport|cell communication by chemical coupling|positive regulation of cell communication by chemical coupling|intercalated disc|gap junction assembly|embryonic limb morphogenesis|embryonic heart tube development|foramen ovale closure|cell projection|negative regulation of blood pressure|positive regulation of vasoconstriction|artery morphogenesis|protein oligomerization|gap junction hemi-channel activity|regulation of cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane depolarization|regulation of ventricular cardiac muscle cell membrane depolarization|ventricular septum morphogenesis|atrial septum morphogenesis|connexin binding|ventricular cardiac muscle cell action potential|SA node cell action potential|gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling|SA node cell to atrial cardiac muscle cell communication by electrical coupling|atrial cardiac muscle cell to AV node cell communication by electrical coupling|AV node cell to bundle of His cell communication by electrical coupling|bundle of His cell to Purkinje myocyte communication by electrical coupling|Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling|cell communication by electrical coupling involved in cardiac conduction|gap junction channel activity involved in cardiac conduction electrical coupling|gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling|gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling|gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling|gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling|regulation of heart rate by cardiac conduction|disordered domain specific binding|positive regulation of blood vessel diameter|regulation of AV node cell action potential|regulation of bundle of His cell action potential|regulation of Purkinje myocyte action potential|regulation of atrial cardiac muscle cell action potential|regulation of renin secretion into blood stream|regulation of membrane depolarization during cardiac muscle cell action potential|vasomotion GJA9 1.51573893087193 2.54640955915669 0.48506830258717 0.190491078248941 -2.39220466497676 0.502335003976947 1 0.0332371 0 0 0 GeneID:81025,Genbank:NM_030772.4,HGNC:HGNC:19155,MIM:611923 gap junction protein alpha 9 GO:0005922,GO:0007154,GO:0016021 connexin complex|cell communication|integral component of membrane GJB1 3.21304300390033 2.54640955915669 3.87967644864396 1.52358697943657 0.607471863805074 0.814195855275146 1 0.0543107 0.0719905 0.177136 0.023619 GeneID:2705,Genbank:NM_001097642.2,HGNC:HGNC:4283,MIM:304040 gap junction protein beta 1 GJB2 128.779468124478 143.665322010952 113.893614238004 0.792770396110777 -0.335025004943178 0.207182676197987 1 2.02088 2.40411 1.99448 1.65822 GeneID:2706,Genbank:NM_004004.5,HGNC:HGNC:4284,MIM:121011 gap junction protein beta 2 GO:0005243,GO:0005922,GO:0007267,GO:0007605,GO:0016021,GO:0016264,GO:0042802 gap junction channel activity|connexin complex|cell-cell signaling|sensory perception of sound|integral component of membrane|gap junction assembly|identical protein binding GJB3 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0.0215839 0.0186599 0.0199339 0.0186198 GeneID:2707,Genbank:NM_024009.2,HGNC:HGNC:4285,MIM:603324 gap junction protein beta 3 GJB4 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0100402 0 0 GeneID:127534,Genbank:NM_153212.2,HGNC:HGNC:4286,MIM:605425 gap junction protein beta 4 GO:0005634,GO:0005730,GO:0005922,GO:0007154,GO:0007608,GO:0016021,GO:0030054,GO:0042048 nucleus|nucleolus|connexin complex|cell communication|sensory perception of smell|integral component of membrane|cell junction|olfactory behavior GJB5 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0262041 0 0 GeneID:2709,Genbank:XM_005270751.3,HGNC:HGNC:4287,MIM:604493 gap junction protein beta 5 GO:0005922,GO:0007154,GO:0008544,GO:0016021,GO:0060707,GO:0060708,GO:0060713,GO:1905867 connexin complex|cell communication|epidermis development|integral component of membrane|trophoblast giant cell differentiation|spongiotrophoblast differentiation|labyrinthine layer morphogenesis|epididymis development GJB6 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0190451 0 0 0 GeneID:10804,Genbank:NM_001110221.2,HGNC:HGNC:4288,MIM:604418 gap junction protein beta 6 GJC1 1572.87920481339 1603.0126630871 1542.74574653967 0.962403967270371 -0.0552855052105576 0.742064675324074 1 8.41619 8.43137 9.41964 6.9162 GeneID:10052,Genbank:XM_024450526.1,HGNC:HGNC:4280,MIM:608655 gap junction protein gamma 1 GO:0001570,GO:0005216,GO:0005789,GO:0005886,GO:0005921,GO:0005922,GO:0006810,GO:0006936,GO:0007043,GO:0007268,GO:0007601,GO:0014704,GO:0016021,GO:0016264,GO:0048468,GO:0048738,GO:0086014,GO:0086020,GO:0086021,GO:0086053,GO:0086077 vasculogenesis|ion channel activity|endoplasmic reticulum membrane|plasma membrane|gap junction|connexin complex|transport|muscle contraction|cell-cell junction assembly|chemical synaptic transmission|visual perception|intercalated disc|integral component of membrane|gap junction assembly|cell development|cardiac muscle tissue development|atrial cardiac muscle cell action potential|gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling|SA node cell to atrial cardiac muscle cell communication by electrical coupling|AV node cell to bundle of His cell communication by electrical coupling|gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling GJC2 43.9577249839106 48.1798678701295 39.7355820976917 0.824734144244652 -0.277998958065022 0.530191070682544 1 1.32103 1.23383 0.933013 1.1795 GeneID:57165,Genbank:NM_020435.3,HGNC:HGNC:17494,MIM:608803 gap junction protein gamma 2 GO:0001932,GO:0005921,GO:0005922,GO:0007267,GO:0007420,GO:0009636,GO:0010628,GO:0010644,GO:0016021,GO:0033270,GO:0043204,GO:0043209,GO:0070447,GO:1903763,GO:1904427,GO:1990769,GO:2000134 regulation of protein phosphorylation|gap junction|connexin complex|cell-cell signaling|brain development|response to toxic substance|positive regulation of gene expression|cell communication by electrical coupling|integral component of membrane|paranode region of axon|perikaryon|myelin sheath|positive regulation of oligodendrocyte progenitor proliferation|gap junction channel activity involved in cell communication by electrical coupling|positive regulation of calcium ion transmembrane transport|proximal neuron projection|negative regulation of G1/S transition of mitotic cell cycle GJC3 2.99278204584242 2.59443583384164 3.3911282578432 1.30707732818425 0.386344495140871 0.921829859631654 1 0.129339 0.0780434 0.0807335 0.187971 GeneID:349149,Genbank:NM_181538.2,HGNC:HGNC:17495,MIM:611925 gap junction protein gamma 3 GO:0005922,GO:0007154,GO:0007605,GO:0016021,GO:0042552,GO:0042803,GO:0043209 connexin complex|cell communication|sensory perception of sound|integral component of membrane|myelination|protein homodimerization activity|myelin sheath GJD3 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.027228 0 0 0 GeneID:125111,Genbank:NM_152219.3,HGNC:HGNC:19147,MIM:607425 gap junction protein delta 3 GO:0005216,GO:0005243,GO:0005887,GO:0005922,GO:0007154,GO:0009749,GO:0009986,GO:0016264 ion channel activity|gap junction channel activity|integral component of plasma membrane|connexin complex|cell communication|response to glucose|cell surface|gap junction assembly GJD4 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0.0408901 0.0346997 0 0 GeneID:219770,Genbank:NM_153368.2,HGNC:HGNC:23296,MIM:611922 gap junction protein delta 4 GO:0005922,GO:0007154,GO:0014717,GO:0016021 connexin complex|cell communication|regulation of satellite cell activation involved in skeletal muscle regeneration|integral component of membrane GK 84.3386258571176 75.1425866320376 93.5346650821977 1.24476238142058 0.315870365695377 0.306242006313825 1 0.661336 0.440058 0.691884 0.702042 GeneID:2710,Genbank:XM_006724486.3,HGNC:HGNC:4289,MIM:300474 glycerol kinase GO:0004370,GO:0005524,GO:0005739,GO:0005741,GO:0005829,GO:0006071,GO:0006641,GO:0019432,GO:0019563,GO:0046167,GO:0070062 glycerol kinase activity|ATP binding|mitochondrion|mitochondrial outer membrane|cytosol|glycerol metabolic process|triglyceride metabolic process|triglyceride biosynthetic process|glycerol catabolic process|glycerol-3-phosphate biosynthetic process|extracellular exosome hsa00561,hsa03320 Glycerolipid metabolism|PPAR signaling pathway GK5 158.871838187805 152.45718128086 165.286495094749 1.08415027554691 0.116564744477762 0.691265557188952 1 0.513545 0.447492 0.645865 0.446839 GeneID:256356,Genbank:NM_001039547.2,HGNC:HGNC:28635 glycerol kinase 5 (putative) GO:0004370,GO:0005524,GO:0005739,GO:0006071,GO:0006641,GO:0019563,GO:0046167 glycerol kinase activity|ATP binding|mitochondrion|glycerol metabolic process|triglyceride metabolic process|glycerol catabolic process|glycerol-3-phosphate biosynthetic process GKAP1 64.2734729500368 64.5727381979313 63.9742077021424 0.990730910404415 -0.0134348305545204 1 1 0.565915 0.528475 0.512895 0.419329 GeneID:80318,Genbank:NM_001135953.1,HGNC:HGNC:17496,MIM:611356 G kinase anchoring protein 1 GO:0005794,GO:0007165,GO:0042802 Golgi apparatus|signal transduction|identical protein binding GKN2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:200504,Genbank:NM_182536.2,HGNC:HGNC:24588 gastrokine 2 GO:0005615,GO:0042127,GO:0045178 extracellular space|regulation of cell proliferation|basal part of cell GLA 1869.21133675373 1802.43045506161 1935.99221844585 1.07410092467599 0.103129558210426 0.470535704649073 1 48.662 50.623 52.5459 54.6699 GeneID:2717,Genbank:NM_000169.2,HGNC:HGNC:4296,MIM:300644 galactosidase alpha GO:0003824,GO:0004557,GO:0005102,GO:0005576,GO:0005737,GO:0005764,GO:0005794,GO:0006687,GO:0009311,GO:0016139,GO:0016787,GO:0016936,GO:0035578,GO:0042803,GO:0043202,GO:0043312,GO:0045019,GO:0046477,GO:0046479,GO:0051001,GO:0052692,GO:0070062 catalytic activity|alpha-galactosidase activity|receptor binding|extracellular region|cytoplasm|lysosome|Golgi apparatus|glycosphingolipid metabolic process|oligosaccharide metabolic process|glycoside catabolic process|hydrolase activity|galactoside binding|azurophil granule lumen|protein homodimerization activity|lysosomal lumen|neutrophil degranulation|negative regulation of nitric oxide biosynthetic process|glycosylceramide catabolic process|glycosphingolipid catabolic process|negative regulation of nitric-oxide synthase activity|raffinose alpha-galactosidase activity|extracellular exosome hsa00052,hsa00561,hsa00600,hsa00603,hsa04142 Galactose metabolism|Glycerolipid metabolism|Sphingolipid metabolism|Glycosphingolipid biosynthesis - globo and isoglobo series|Lysosome GLB1 3609.4591995846 3410.91338981196 3808.00500935723 1.11641797201047 0.158877254097132 0.247692478325347 1 35.3646 38.6609 40.7746 43.4832 GeneID:2720,Genbank:NM_001135602.2,HGNC:HGNC:4298,MIM:611458 galactosidase beta 1 hsa00052,hsa00511,hsa00531,hsa00600,hsa00604,hsa04142 Galactose metabolism|Other glycan degradation|Glycosaminoglycan degradation|Sphingolipid metabolism|Glycosphingolipid biosynthesis - ganglio series|Lysosome GLB1L 149.644700300107 131.595833405649 167.693567194564 1.27430757383968 0.349713536383635 0.158651282060105 1 1.57528 1.17405 2.0716 1.58138 GeneID:79411,Genbank:NM_024506.4,HGNC:HGNC:28129 galactosidase beta 1 like GO:0004565,GO:0005615,GO:0005773,GO:0005975 beta-galactosidase activity|extracellular space|vacuole|carbohydrate metabolic process GLCCI1 87.7885442572252 98.5121264468282 77.0649620676222 0.782289093203342 -0.354226244059263 0.263559678659856 1 0.94694 0.944699 0.88217 0.616226 GeneID:113263,Genbank:NM_138426.3,HGNC:HGNC:18713,MIM:614283 glucocorticoid induced 1 GLCE 440.570874509545 500.208652565864 380.933096453225 0.761548394853217 -0.392992374922968 0.0315330446441022 0.705022653979306 2.69809 2.34049 2.11332 1.7939 GeneID:26035,Genbank:XM_005254298.3,HGNC:HGNC:17855,MIM:612134 glucuronic acid epimerase GO:0000139,GO:0005794,GO:0015012,GO:0016021,GO:0016857,GO:0030210,GO:0047464,GO:0050379 Golgi membrane|Golgi apparatus|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|racemase and epimerase activity, acting on carbohydrates and derivatives|heparin biosynthetic process|heparosan-N-sulfate-glucuronate 5-epimerase activity|UDP-glucuronate 5'-epimerase activity hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin GLDC 155.744515538622 174.356506889779 137.132524187465 0.786506489684122 -0.346469425118654 0.165835945604299 1 1.40958 1.42672 1.01717 1.28797 GeneID:2731,Genbank:NM_000170.2,HGNC:HGNC:4313,MIM:238300 glycine decarboxylase GO:0004375,GO:0005634,GO:0005739,GO:0005759,GO:0005886,GO:0005960,GO:0006546,GO:0009055,GO:0016594,GO:0016829,GO:0019464,GO:0019899,GO:0030170,GO:0036255,GO:0042803,GO:0070280,GO:1903442,GO:1990830 glycine dehydrogenase (decarboxylating) activity|nucleus|mitochondrion|mitochondrial matrix|plasma membrane|glycine cleavage complex|glycine catabolic process|electron transfer activity|glycine binding|lyase activity|glycine decarboxylation via glycine cleavage system|enzyme binding|pyridoxal phosphate binding|response to methylamine|protein homodimerization activity|pyridoxal binding|response to lipoic acid|cellular response to leukemia inhibitory factor hsa00260,hsa00630 Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism GLDN 7.58465359140467 9.83964565872424 5.32966152408509 0.541651773746506 -0.884562449479954 0.4395344728867 1 0.057958 0.0345667 0.020134 0.0281864 GeneID:342035,Genbank:NM_181789.3,HGNC:HGNC:29514,MIM:608603 gliomedin GO:0005578,GO:0005581,GO:0005615,GO:0005886,GO:0016021,GO:0030424,GO:0032528,GO:0045162,GO:0086080 proteinaceous extracellular matrix|collagen trimer|extracellular space|plasma membrane|integral component of membrane|axon|microvillus organization|clustering of voltage-gated sodium channels|protein binding involved in heterotypic cell-cell adhesion GLE1 1011.62937893854 828.695485697078 1194.56327218001 1.44149846692501 0.527569302486051 0.000554005347590526 0.0663583556644534 6.68185 6.63276 9.63059 10.0839 GeneID:2733,Genbank:NM_001003722.1,HGNC:HGNC:4315,MIM:603371 GLE1, RNA export mediator GO:0000822,GO:0005543,GO:0005615,GO:0005643,GO:0005730,GO:0005737,GO:0005829,GO:0006406,GO:0006446,GO:0006449,GO:0016020,GO:0016973,GO:0031369,GO:0031965,GO:0042802,GO:0044614 inositol hexakisphosphate binding|phospholipid binding|extracellular space|nuclear pore|nucleolus|cytoplasm|cytosol|mRNA export from nucleus|regulation of translational initiation|regulation of translational termination|membrane|poly(A)+ mRNA export from nucleus|translation initiation factor binding|nuclear membrane|identical protein binding|nuclear pore cytoplasmic filaments GLG1 3872.38593460893 3623.84821628486 4120.923652933 1.13716784119555 0.185445205672469 0.169396321180153 1 14.8214 15.037 18.0891 16.164 GeneID:2734,Genbank:NM_001145666.1,HGNC:HGNC:4316,MIM:600753 golgi glycoprotein 1 GO:0000139,GO:0005102,GO:0005578,GO:0005794,GO:0005886,GO:0010955,GO:0016020,GO:0016021,GO:0017134,GO:0030512,GO:0032330,GO:0050900,GO:0060349,GO:0070062 Golgi membrane|receptor binding|proteinaceous extracellular matrix|Golgi apparatus|plasma membrane|negative regulation of protein processing|membrane|integral component of membrane|fibroblast growth factor binding|negative regulation of transforming growth factor beta receptor signaling pathway|regulation of chondrocyte differentiation|leukocyte migration|bone morphogenesis|extracellular exosome hsa04514 Cell adhesion molecules (CAMs) GLI1 11.6064746879002 14.4904196497652 8.72252972603509 0.601951491872523 -0.732280862478196 0.413082846434055 1 0.126475 0.0770303 0.0271365 0.0763001 GeneID:2735,Genbank:NM_001160045.1,HGNC:HGNC:4317,MIM:165220 GLI family zinc finger 1 hsa04024,hsa04340,hsa05200,hsa05217 cAMP signaling pathway|Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma GLI2 8.45242958975883 8.66739775606975 8.23746142344792 0.950396146026557 -0.0733991090429254 1 1 0.0218623 0.0276845 0.0204374 0.0245512 GeneID:2736,Genbank:XM_024452794.1,HGNC:HGNC:4318,MIM:165230 GLI family zinc finger 2 GO:0000122,GO:0000978,GO:0001077,GO:0001501,GO:0001649,GO:0001701,GO:0001822,GO:0002062,GO:0002076,GO:0003700,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005929,GO:0005930,GO:0007224,GO:0007389,GO:0007411,GO:0007418,GO:0007442,GO:0007507,GO:0008134,GO:0008270,GO:0008283,GO:0008589,GO:0009612,GO:0009913,GO:0009952,GO:0009954,GO:0016020,GO:0016607,GO:0021508,GO:0021513,GO:0021517,GO:0021696,GO:0021775,GO:0021776,GO:0021938,GO:0021965,GO:0021983,GO:0030324,GO:0030879,GO:0030902,GO:0031514,GO:0032331,GO:0033089,GO:0035295,GO:0042475,GO:0042733,GO:0043066,GO:0043565,GO:0045666,GO:0045740,GO:0045893,GO:0045944,GO:0048566,GO:0048589,GO:0048666,GO:0048754,GO:0060032,GO:0060513,GO:0060603,GO:0060831,GO:0071407,GO:0090103,GO:0097542,GO:0097546,GO:0098586,GO:1990841 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|skeletal system development|osteoblast differentiation|in utero embryonic development|kidney development|chondrocyte differentiation|osteoblast development|DNA binding transcription factor activity|nucleus|nucleoplasm|nucleolus|cytosol|cilium|axoneme|smoothened signaling pathway|pattern specification process|axon guidance|ventral midline development|hindgut morphogenesis|heart development|transcription factor binding|zinc ion binding|cell proliferation|regulation of smoothened signaling pathway|response to mechanical stimulus|epidermal cell differentiation|anterior/posterior pattern specification|proximal/distal pattern formation|membrane|nuclear speck|floor plate formation|spinal cord dorsal/ventral patterning|ventral spinal cord development|cerebellar cortex morphogenesis|smoothened signaling pathway involved in ventral spinal cord interneuron specification|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|spinal cord ventral commissure morphogenesis|pituitary gland development|lung development|mammary gland development|hindbrain development|motile cilium|negative regulation of chondrocyte differentiation|positive regulation of T cell differentiation in thymus|tube development|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|negative regulation of apoptotic process|sequence-specific DNA binding|positive regulation of neuron differentiation|positive regulation of DNA replication|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|embryonic digestive tract development|developmental growth|neuron development|branching morphogenesis of an epithelial tube|notochord regression|prostatic bud formation|mammary gland duct morphogenesis|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|cellular response to organic cyclic compound|cochlea morphogenesis|ciliary tip|ciliary base|cellular response to virus|promoter-specific chromatin binding hsa04340,hsa04390,hsa05200,hsa05217 Hedgehog signaling pathway|Hippo signaling pathway|Pathways in cancer|Basal cell carcinoma GLI3 1871.23031343097 1802.72842136483 1939.7322054971 1.07599801640036 0.105675418292303 0.603698591107936 1 4.95348 5.23423 6.49558 4.63542 GeneID:2737,Genbank:NM_000168.5,HGNC:HGNC:4319,MIM:165240 GLI family zinc finger 3 GO:0000122,GO:0000977,GO:0000978,GO:0001077,GO:0001656,GO:0001658,GO:0001701,GO:0002052,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005929,GO:0005930,GO:0007224,GO:0007411,GO:0007442,GO:0007507,GO:0008013,GO:0008285,GO:0009952,GO:0009954,GO:0016485,GO:0016607,GO:0017053,GO:0021631,GO:0021766,GO:0021775,GO:0021776,GO:0021798,GO:0021819,GO:0021861,GO:0022018,GO:0030318,GO:0030324,GO:0030850,GO:0032332,GO:0033077,GO:0035035,GO:0035108,GO:0042060,GO:0042307,GO:0042475,GO:0042733,GO:0042826,GO:0043066,GO:0043585,GO:0043586,GO:0043627,GO:0045060,GO:0045665,GO:0045669,GO:0045879,GO:0045892,GO:0045893,GO:0045944,GO:0046638,GO:0046639,GO:0046872,GO:0048557,GO:0048566,GO:0048589,GO:0048593,GO:0048704,GO:0048709,GO:0060021,GO:0060364,GO:0060366,GO:0060367,GO:0060594,GO:0060831,GO:0060840,GO:0060873,GO:0060875,GO:0061005,GO:0070242,GO:0090090,GO:0097421,GO:0097542,GO:0097546,GO:1903010 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|metanephros development|branching involved in ureteric bud morphogenesis|in utero embryonic development|positive regulation of neuroblast proliferation|chromatin binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|cilium|axoneme|smoothened signaling pathway|axon guidance|hindgut morphogenesis|heart development|beta-catenin binding|negative regulation of cell proliferation|anterior/posterior pattern specification|proximal/distal pattern formation|protein processing|nuclear speck|transcriptional repressor complex|optic nerve morphogenesis|hippocampus development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|forebrain dorsal/ventral pattern formation|layer formation in cerebral cortex|forebrain radial glial cell differentiation|lateral ganglionic eminence cell proliferation|melanocyte differentiation|lung development|prostate gland development|positive regulation of chondrocyte differentiation|T cell differentiation in thymus|histone acetyltransferase binding|limb morphogenesis|wound healing|positive regulation of protein import into nucleus|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|histone deacetylase binding|negative regulation of apoptotic process|nose morphogenesis|tongue development|response to estrogen|negative thymic T cell selection|negative regulation of neuron differentiation|positive regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of alpha-beta T cell differentiation|negative regulation of alpha-beta T cell differentiation|metal ion binding|embryonic digestive tract morphogenesis|embryonic digestive tract development|developmental growth|camera-type eye morphogenesis|embryonic skeletal system morphogenesis|oligodendrocyte differentiation|palate development|frontal suture morphogenesis|lambdoid suture morphogenesis|sagittal suture morphogenesis|mammary gland specification|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|artery development|anterior semicircular canal development|lateral semicircular canal development|cell differentiation involved in kidney development|thymocyte apoptotic process|negative regulation of canonical Wnt signaling pathway|liver regeneration|ciliary tip|ciliary base|regulation of bone development hsa04024,hsa04340,hsa05200,hsa05217 cAMP signaling pathway|Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma GLI4 130.787879404012 121.525865028608 140.049893779416 1.15242869282557 0.20467748584804 0.450765342593688 1 6.14101 5.43128 5.53306 6.73908 GeneID:2738,Genbank:NM_138465.3,HGNC:HGNC:4320,MIM:165280 GLI family zinc finger 4 GO:0003677,GO:0003700,GO:0005634,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|metal ion binding GLIPR1 1538.89818061765 1519.50841965561 1558.28794157969 1.02552109710117 0.0363571713596081 0.856807143806994 1 14.292 13.5431 16.8173 11.817 GeneID:11010,Genbank:NM_006851.2,HGNC:HGNC:17001,MIM:602692 GLI pathogenesis related 1 GO:0005576,GO:0005886,GO:0016020,GO:0016021,GO:0019216,GO:0035577,GO:0043312 extracellular region|plasma membrane|membrane|integral component of membrane|regulation of lipid metabolic process|azurophil granule membrane|neutrophil degranulation GLIPR1L1 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0108548 0 0 GeneID:256710,Genbank:XM_017019134.1,HGNC:HGNC:28392,MIM:610395 GLIPR1 like 1 GO:0001669,GO:0005576,GO:0005886,GO:0007338,GO:0031225,GO:0045121 acrosomal vesicle|extracellular region|plasma membrane|single fertilization|anchored component of membrane|membrane raft GLIPR1L2 4.99609082898662 5.6309167949557 4.36126486301754 0.774521276344283 -0.368623224039366 0.852482997814629 1 0.0330728 0.0325944 0.0214377 0.0496358 GeneID:144321,Genbank:NM_001270396.1,HGNC:HGNC:28592,MIM:610394 GLIPR1 like 2 GO:0016021 integral component of membrane GLIPR2 1409.43980015011 1380.55577456891 1438.32382573131 1.04184405456595 0.0591393481141346 0.716255702586949 1 20.0016 22.5407 21.7414 22.0852 GeneID:152007,Genbank:NM_001287011.1,HGNC:HGNC:18007,MIM:607141 GLI pathogenesis related 2 GO:0000139,GO:0010634,GO:0010718,GO:0042803,GO:0070062,GO:0070374 Golgi membrane|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|protein homodimerization activity|extracellular exosome|positive regulation of ERK1 and ERK2 cascade GLIS1 3.21423959550533 3.03648096111406 3.3919982298966 1.11708200161153 0.159735093588509 1 1 0 0.0139808 0.0147182 0.0137599 GeneID:148979,Genbank:NM_147193.2,HGNC:HGNC:29525,MIM:610378 GLIS family zinc finger 1 GO:0000122,GO:0000977,GO:0001227,GO:0001228,GO:0005634,GO:0006366,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|metal ion binding GLIS2 290.652715742872 334.13635023553 247.169081250214 0.739725208215109 -0.434938654376545 0.0297148125209207 0.683058083067491 3.58139 3.57708 2.87513 2.51253 GeneID:84662,Genbank:NM_001318918.1,HGNC:HGNC:29450,MIM:608539 GLIS family zinc finger 2 GO:0000122,GO:0000977,GO:0001077,GO:0005634,GO:0005737,GO:0007399,GO:0016607,GO:0043433,GO:0044212,GO:0045879,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0060994,GO:0061005,GO:0097730,GO:1900182 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|cytoplasm|nervous system development|nuclear speck|negative regulation of DNA binding transcription factor activity|transcription regulatory region DNA binding|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|regulation of transcription from RNA polymerase II promoter involved in kidney development|cell differentiation involved in kidney development|non-motile cilium|positive regulation of protein localization to nucleus GLIS3 1287.83883861678 1275.26685838724 1300.41081884632 1.01971662659757 0.0281682912147086 0.873472214116764 1 3.85466 3.84676 4.57432 3.40857 GeneID:169792,Genbank:XM_011517763.2,HGNC:HGNC:28510,MIM:610192 GLIS family zinc finger 3 GO:0000122,GO:0003677,GO:0005634,GO:0006366,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|nucleus|transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|metal ion binding GLMN 128.608522521403 153.03349657708 104.183548465727 0.680789178813882 -0.554719989408172 0.103306848697864 1 1.44569 1.13222 0.868537 0.85646 GeneID:11146,Genbank:XM_011540546.2,HGNC:HGNC:14373,MIM:601749 glomulin, FKBP associated protein GLMP 533.556683989131 501.555422258752 565.557945719509 1.12760807803158 0.173265718329909 0.328506802688144 1 7.14705 7.05087 8.97356 8.82794 GeneID:112770,Genbank:NM_001256605.1,HGNC:HGNC:29436 glycosylated lysosomal membrane protein GO:0003700,GO:0004879,GO:0005634,GO:0005764,GO:0005765,GO:0005829,GO:0016021,GO:0030374,GO:0044212,GO:0045944 DNA binding transcription factor activity|nuclear receptor activity|nucleus|lysosome|lysosomal membrane|cytosol|integral component of membrane|ligand-dependent nuclear receptor transcription coactivator activity|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter GLO1 4512.41227187109 4754.21661882614 4270.60792491605 0.898277942995897 -0.154766185623369 0.25303648791094 1 104.795 104.372 97.5363 90.2957 GeneID:2739,Genbank:NM_006708.2,HGNC:HGNC:4323,MIM:138750 glyoxalase I GO:0004462,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006090,GO:0006357,GO:0006749,GO:0008270,GO:0009438,GO:0030316,GO:0043066,GO:0070062 lactoylglutathione lyase activity|nucleus|cytoplasm|cytosol|plasma membrane|carbohydrate metabolic process|pyruvate metabolic process|regulation of transcription from RNA polymerase II promoter|glutathione metabolic process|zinc ion binding|methylglyoxal metabolic process|osteoclast differentiation|negative regulation of apoptotic process|extracellular exosome hsa00620 Pyruvate metabolism GLOD4 1722.60213478398 1781.56031553215 1663.64395403582 0.933812871521501 -0.0987946203014164 0.478590724251927 1 19.3179 21.5324 18.6374 20.4333 GeneID:51031,Genbank:NM_016080.3,HGNC:HGNC:14111 glyoxalase domain containing 4 GO:0005739,GO:0045296,GO:0070062 mitochondrion|cadherin binding|extracellular exosome GLP2R 3.02353822666188 3.6226049124413 2.42447154088245 0.669261926012401 -0.579357152473458 0.839799246569478 1 0.0214819 0.00660096 0.0272432 0.00634583 GeneID:9340,Genbank:XM_017025340.1,HGNC:HGNC:4325,MIM:603659 glucagon like peptide 2 receptor GO:0004930,GO:0004967,GO:0005886,GO:0007166,GO:0007186,GO:0007188,GO:0008284,GO:0016021 G-protein coupled receptor activity|glucagon receptor activity|plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|positive regulation of cell proliferation|integral component of membrane hsa04080 Neuroactive ligand-receptor interaction GLRA1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.021914 0 0 0 GeneID:2741,Genbank:NM_001292000.1,HGNC:HGNC:4326,MIM:138491 glycine receptor alpha 1 GO:0001508,GO:0001964,GO:0002087,GO:0004888,GO:0005783,GO:0005886,GO:0005887,GO:0006811,GO:0006821,GO:0006936,GO:0007218,GO:0007268,GO:0007340,GO:0007601,GO:0007628,GO:0008270,GO:0009897,GO:0016021,GO:0016594,GO:0016934,GO:0022824,GO:0030054,GO:0030425,GO:0030977,GO:0034707,GO:0042391,GO:0042802,GO:0043005,GO:0043025,GO:0043204,GO:0043231,GO:0045202,GO:0045211,GO:0050884,GO:0051260,GO:0051291,GO:0051970,GO:0060012,GO:0060013,GO:0060077,GO:0060080,GO:0071230,GO:0071294,GO:0071361,GO:0097305,GO:1902476,GO:2000344 action potential|startle response|regulation of respiratory gaseous exchange by neurological system process|transmembrane signaling receptor activity|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|ion transport|chloride transport|muscle contraction|neuropeptide signaling pathway|chemical synaptic transmission|acrosome reaction|visual perception|adult walking behavior|zinc ion binding|external side of plasma membrane|integral component of membrane|glycine binding|extracellularly glycine-gated chloride channel activity|transmitter-gated ion channel activity|cell junction|dendrite|taurine binding|chloride channel complex|regulation of membrane potential|identical protein binding|neuron projection|neuronal cell body|perikaryon|intracellular membrane-bounded organelle|synapse|postsynaptic membrane|neuromuscular process controlling posture|protein homooligomerization|protein heterooligomerization|negative regulation of transmission of nerve impulse|synaptic transmission, glycinergic|righting reflex|inhibitory synapse|inhibitory postsynaptic potential|cellular response to amino acid stimulus|cellular response to zinc ion|cellular response to ethanol|response to alcohol|chloride transmembrane transport|positive regulation of acrosome reaction hsa04080 Neuroactive ligand-receptor interaction GLRA2 9.79320112830139 5.04479284362845 14.5416094129743 2.88249881882471 1.52732001669714 0.115600245210074 1 0.0207393 0.0487105 0.158838 0.101562 GeneID:2742,Genbank:NM_002063.3,HGNC:HGNC:4327,MIM:305990 glycine receptor alpha 2 GO:0004888,GO:0005886,GO:0005887,GO:0007218,GO:0007268,GO:0016594,GO:0016934,GO:0022852,GO:0030054,GO:0034220,GO:0034707,GO:0042995,GO:0045211,GO:0046872,GO:0060012,GO:0071230,GO:0071294,GO:0071361,GO:1902476 transmembrane signaling receptor activity|plasma membrane|integral component of plasma membrane|neuropeptide signaling pathway|chemical synaptic transmission|glycine binding|extracellularly glycine-gated chloride channel activity|glycine-gated chloride ion channel activity|cell junction|ion transmembrane transport|chloride channel complex|cell projection|postsynaptic membrane|metal ion binding|synaptic transmission, glycinergic|cellular response to amino acid stimulus|cellular response to zinc ion|cellular response to ethanol|chloride transmembrane transport hsa04080 Neuroactive ligand-receptor interaction GLRA4 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0 GeneID:441509,Genbank:NM_001024452.2,HGNC:HGNC:31715 glycine receptor alpha 4 GO:0004888,GO:0005887,GO:0007218,GO:0016594,GO:0016934,GO:0022824,GO:0030054,GO:0030425,GO:0034707,GO:0043200,GO:0043204,GO:0045211,GO:0060012 transmembrane signaling receptor activity|integral component of plasma membrane|neuropeptide signaling pathway|glycine binding|extracellularly glycine-gated chloride channel activity|transmitter-gated ion channel activity|cell junction|dendrite|chloride channel complex|response to amino acid|perikaryon|postsynaptic membrane|synaptic transmission, glycinergic GLRB 527.935733208899 543.631885240475 512.239581177324 0.942254483382142 -0.08581134043122 0.650116494749763 1 6.9283 5.82536 6.26907 6.34913 GeneID:2743,Genbank:NM_000824.4,HGNC:HGNC:4329,MIM:138492 glycine receptor beta GO:0001964,GO:0004888,GO:0005737,GO:0005886,GO:0005887,GO:0006811,GO:0007218,GO:0007268,GO:0007340,GO:0007399,GO:0007601,GO:0007628,GO:0016594,GO:0016933,GO:0016934,GO:0016935,GO:0030054,GO:0030425,GO:0043200,GO:0045211,GO:0051291,GO:0060012,GO:0060013,GO:0097112,GO:0098982,GO:1902476 startle response|transmembrane signaling receptor activity|cytoplasm|plasma membrane|integral component of plasma membrane|ion transport|neuropeptide signaling pathway|chemical synaptic transmission|acrosome reaction|nervous system development|visual perception|adult walking behavior|glycine binding|extracellularly glycine-gated ion channel activity|extracellularly glycine-gated chloride channel activity|glycine-gated chloride channel complex|cell junction|dendrite|response to amino acid|postsynaptic membrane|protein heterooligomerization|synaptic transmission, glycinergic|righting reflex|gamma-aminobutyric acid receptor clustering|GABA-ergic synapse|chloride transmembrane transport hsa04080 Neuroactive ligand-receptor interaction GLRX 380.950264699261 363.087763569737 398.812765828785 1.09839219561633 0.135393279882407 0.459866385525602 1 7.8919 7.45692 8.08123 9.09738 GeneID:2745,Genbank:NM_001118890.1,HGNC:HGNC:4330,MIM:600443 glutaredoxin GLRX2 300.783142225981 329.725707617914 271.840576834048 0.824444593046584 -0.278505554557425 0.19697428780499 1 8.80597 9.60663 6.92819 9.02541 GeneID:51022,Genbank:NM_016066.4,HGNC:HGNC:16065,MIM:606820 glutaredoxin 2 GO:0005739,GO:0009055,GO:0015035,GO:0045454,GO:0046872,GO:0051537 mitochondrion|electron transfer activity|protein disulfide oxidoreductase activity|cell redox homeostasis|metal ion binding|2 iron, 2 sulfur cluster binding GLRX3 2587.64327727054 2763.42356797525 2411.86298656583 0.872780783415331 -0.196308757635338 0.152597309658211 1 23.1356 24.22 19.6918 21.3892 GeneID:10539,Genbank:NM_001199868.1,HGNC:HGNC:15987,MIM:612754 glutaredoxin 3 GO:0002026,GO:0003723,GO:0005080,GO:0005634,GO:0005829,GO:0005938,GO:0009055,GO:0010614,GO:0015035,GO:0030018,GO:0030425,GO:0042802,GO:0044571,GO:0045454,GO:0046872,GO:0051536,GO:0070062,GO:0097428 regulation of the force of heart contraction|RNA binding|protein kinase C binding|nucleus|cytosol|cell cortex|electron transfer activity|negative regulation of cardiac muscle hypertrophy|protein disulfide oxidoreductase activity|Z disc|dendrite|identical protein binding|[2Fe-2S] cluster assembly|cell redox homeostasis|metal ion binding|iron-sulfur cluster binding|extracellular exosome|protein maturation by iron-sulfur cluster transfer GLRX5 1389.11338052141 1343.28971370908 1434.93704733374 1.06822603693703 0.0952169540142357 0.516126769831264 1 66.4103 66.1926 71.3813 72.1641 GeneID:51218,Genbank:NM_016417.2,HGNC:HGNC:20134,MIM:609588 glutaredoxin 5 GO:0005634,GO:0005739,GO:0005759,GO:0009055,GO:0009249,GO:0015035,GO:0030097,GO:0030425,GO:0043025,GO:0044281,GO:0045454,GO:0046872,GO:0051537 nucleus|mitochondrion|mitochondrial matrix|electron transfer activity|protein lipoylation|protein disulfide oxidoreductase activity|hemopoiesis|dendrite|neuronal cell body|small molecule metabolic process|cell redox homeostasis|metal ion binding|2 iron, 2 sulfur cluster binding GLS 1968.90033656179 2311.14854990096 1626.65212322261 0.703828459357283 -0.506704244136653 0.0536819227207321 0.845397909828167 9.92017 8.68796 7.87 5.35165 GeneID:2744,Genbank:NM_014905.4,HGNC:HGNC:4331,MIM:138280 glutaminase GO:0001967,GO:0002087,GO:0004359,GO:0005739,GO:0005759,GO:0005829,GO:0006537,GO:0006543,GO:0007268,GO:0008652,GO:0014047,GO:0051289 suckling behavior|regulation of respiratory gaseous exchange by neurological system process|glutaminase activity|mitochondrion|mitochondrial matrix|cytosol|glutamate biosynthetic process|glutamine catabolic process|chemical synaptic transmission|cellular amino acid biosynthetic process|glutamate secretion|protein homotetramerization hsa00220,hsa00250,hsa00471,hsa04724,hsa04727,hsa04964,hsa05206,hsa05230 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Glutamatergic synapse|GABAergic synapse|Proximal tubule bicarbonate reclamation|MicroRNAs in cancer|Central carbon metabolism in cancer GLS2 4.07441548452392 5.72696934432558 2.42186162472226 0.422887129144824 -1.24165544324968 0.463785170914314 1 0.0799118 0.0429918 0.0149955 0.0558374 GeneID:27165,Genbank:NM_001280798.1,HGNC:HGNC:29570,MIM:606365 glutaminase 2 GO:0004359,GO:0005739,GO:0005759,GO:0006520,GO:0006537,GO:0006543,GO:0008652,GO:0014047,GO:0042981,GO:0072593,GO:1903955 glutaminase activity|mitochondrion|mitochondrial matrix|cellular amino acid metabolic process|glutamate biosynthetic process|glutamine catabolic process|cellular amino acid biosynthetic process|glutamate secretion|regulation of apoptotic process|reactive oxygen species metabolic process|positive regulation of protein targeting to mitochondrion hsa00220,hsa00250,hsa00471,hsa04724,hsa04727,hsa04964,hsa05206,hsa05230 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Glutamatergic synapse|GABAergic synapse|Proximal tubule bicarbonate reclamation|MicroRNAs in cancer|Central carbon metabolism in cancer GLT8D1 897.500467027655 899.87928349388 895.121650561431 0.994713032048058 -0.00764771692409786 0.965844514565484 1 10.4815 10.9127 10.9897 10.3562 GeneID:55830,Genbank:NM_001278281.1,HGNC:HGNC:24870 glycosyltransferase 8 domain containing 1 GO:0000271,GO:0005794,GO:0016020,GO:0016021,GO:0016757 polysaccharide biosynthetic process|Golgi apparatus|membrane|integral component of membrane|transferase activity, transferring glycosyl groups GLT8D2 130.987461819291 111.734245644569 150.240677994013 1.344625160597 0.427204050613158 0.111230683813884 1 1.26986 1.16506 1.83743 1.62884 GeneID:83468,Genbank:NM_001316967.1,HGNC:HGNC:24890 glycosyltransferase 8 domain containing 2 GO:0000271,GO:0005794,GO:0016021,GO:0016757 polysaccharide biosynthetic process|Golgi apparatus|integral component of membrane|transferase activity, transferring glycosyl groups GLTP 873.790867773589 789.990670598409 957.591064948768 1.21215490332741 0.277574075033906 0.0782027074120188 0.941663557975371 10.0715 10.7499 12.3985 12.5955 GeneID:51228,Genbank:NM_016433.3,HGNC:HGNC:24867,MIM:608949 glycolipid transfer protein GO:0005829,GO:0006687,GO:0008289,GO:0016020,GO:0017089,GO:0042802,GO:0051861,GO:0070062,GO:0120009,GO:0120013 cytosol|glycosphingolipid metabolic process|lipid binding|membrane|glycolipid transporter activity|identical protein binding|glycolipid binding|extracellular exosome|intermembrane lipid transfer|intermembrane lipid transfer activity GLTPD2 4.18307124259957 3.03648096111406 5.32966152408509 1.75520992633844 0.811643589832066 0.65194268696822 1 0 0 0.131823 0.123412 GeneID:388323,Genbank:NM_001014985.2,HGNC:HGNC:33756 glycolipid transfer protein domain containing 2 GO:0005737,GO:0120013 cytoplasm|intermembrane lipid transfer activity GLUD1 3745.13128486768 3765.80115871481 3724.46141102056 0.98902232328476 -0.0159250103754147 0.912960402788844 1 38.3251 38.5393 40.3501 36.3181 GeneID:2746,Genbank:NM_005271.4,HGNC:HGNC:4335,MIM:138130 glutamate dehydrogenase 1 hsa00220,hsa00250,hsa00471,hsa00910,hsa04217,hsa04964 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Nitrogen metabolism|Necroptosis|Proximal tubule bicarbonate reclamation GLUD2 7.72406553029978 8.17732635411239 7.27080470648717 0.889142048590328 -0.169514173665822 0.93248993810592 1 0.0767662 0.159202 0.145702 0.101423 GeneID:2747,Genbank:NM_012084.3,HGNC:HGNC:4336,MIM:300144 glutamate dehydrogenase 2 GO:0004352,GO:0004353,GO:0005525,GO:0005739,GO:0006536,GO:0006537,GO:0006538,GO:0043531,GO:0055114,GO:0070728 glutamate dehydrogenase (NAD+) activity|glutamate dehydrogenase [NAD(P)+] activity|GTP binding|mitochondrion|glutamate metabolic process|glutamate biosynthetic process|glutamate catabolic process|ADP binding|oxidation-reduction process|leucine binding hsa00220,hsa00250,hsa00471,hsa00910,hsa04217,hsa04964 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|D-Glutamine and D-glutamate metabolism|Nitrogen metabolism|Necroptosis|Proximal tubule bicarbonate reclamation GLUL 1634.93659026703 1580.91345772605 1688.95972280802 1.06834419971184 0.0953765301858822 0.520102869133106 1 6.57436 7.17694 7.72098 7.07161 GeneID:2752,Genbank:NM_001033044.3,HGNC:HGNC:4341,MIM:138290 glutamate-ammonia ligase hsa00220,hsa00250,hsa00630,hsa00910,hsa04217,hsa04724,hsa04727 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Glyoxylate and dicarboxylate metabolism|Nitrogen metabolism|Necroptosis|Glutamatergic synapse|GABAergic synapse GLYAT 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0137017 0.0127544 GeneID:10249,Genbank:NM_201648.2,HGNC:HGNC:13734,MIM:607424 glycine-N-acyltransferase GO:0005739,GO:0005759,GO:0006544,GO:0006637,GO:0006805,GO:0009636,GO:0016746,GO:0032787,GO:0047961,GO:0047962,GO:0070062,GO:1901787 mitochondrion|mitochondrial matrix|glycine metabolic process|acyl-CoA metabolic process|xenobiotic metabolic process|response to toxic substance|transferase activity, transferring acyl groups|monocarboxylic acid metabolic process|glycine N-acyltransferase activity|glycine N-benzoyltransferase activity|extracellular exosome|benzoyl-CoA metabolic process hsa00360 Phenylalanine metabolism GLYATL1 12.2065068060133 12.7800740704684 11.6329395415581 0.910240384947295 -0.135680498615672 0.9151774710767 1 0.0887724 0.10487 0.085094 0.069266 GeneID:92292,Genbank:NM_001354699.1,HGNC:HGNC:30519,MIM:614761 glycine-N-acyltransferase like 1 GO:0005739,GO:0006541,GO:0047946,GO:0047961 mitochondrion|glutamine metabolic process|glutamine N-acyltransferase activity|glycine N-acyltransferase activity GLYATL2 78.2448875152175 81.3694360334285 75.1203389970066 0.923200929721885 -0.115283418017835 0.756975710793637 1 1.21892 1.0332 1.09013 0.947834 GeneID:219970,Genbank:XM_024448395.1,HGNC:HGNC:24178,MIM:614762 glycine-N-acyltransferase like 2 GO:0005739,GO:0005783,GO:0042758,GO:0047961,GO:0051793,GO:1903965 mitochondrion|endoplasmic reticulum|long-chain fatty acid catabolic process|glycine N-acyltransferase activity|medium-chain fatty acid catabolic process|monounsaturated fatty acid catabolic process GLYATL3 6.9359290533086 5.6309167949557 8.24094131166151 1.46351679695284 0.549439303820802 0.671391134878472 1 0.117519 0.131506 0.201385 0.1252 GeneID:389396,Genbank:NM_001010904.1,HGNC:HGNC:21349,MIM:614763 glycine-N-acyltransferase like 3 GO:0005739,GO:0047961 mitochondrion|glycine N-acyltransferase activity GLYCTK 206.332849305418 198.946320881909 213.719377728928 1.07425649683558 0.103338502198319 0.668946968053046 1 1.23247 1.3616 1.45621 1.47031 GeneID:132158,Genbank:XM_017005730.1,HGNC:HGNC:24247,MIM:610516 glycerate kinase GO:0005524,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0006468,GO:0008887,GO:0061624 ATP binding|cytoplasm|mitochondrion|Golgi apparatus|cytosol|protein phosphorylation|glycerate kinase activity|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate hsa00030,hsa00260,hsa00561,hsa00630 Pentose phosphate pathway|Glycine, serine and threonine metabolism|Glycerolipid metabolism|Glyoxylate and dicarboxylate metabolism GLYR1 2500.98735619255 2426.59672935651 2575.37798302859 1.06131272323586 0.0858498191043843 0.537030574609464 1 15.5516 15.2548 17.7762 15.9444 GeneID:84656,Genbank:XM_005255639.5,HGNC:HGNC:24434,MIM:610660 glyoxylate reductase 1 homolog GO:0000786,GO:0003677,GO:0004616,GO:0005654,GO:0005794,GO:0005829,GO:0016607,GO:0035064,GO:0042393,GO:0051287 nucleosome|DNA binding|phosphogluconate dehydrogenase (decarboxylating) activity|nucleoplasm|Golgi apparatus|cytosol|nuclear speck|methylated histone binding|histone binding|NAD binding GM2A 1031.24994242758 983.738311157527 1078.76157369763 1.09659404484135 0.133029544075476 0.391291267086958 1 11.6938 12.5542 13.5825 13.5793 GeneID:2760,Genbank:NM_000405.4,HGNC:HGNC:4367,MIM:613109 GM2 ganglioside activator hsa04142 Lysosome GMCL1 368.313028331872 371.16903737448 365.457019289265 0.984610736591557 -0.0223746235017203 0.931872864175423 1 3.83359 3.65495 4.25343 3.05201 GeneID:64395,Genbank:NM_178439.4,HGNC:HGNC:23843 germ cell-less, spermatogenesis associated 1 GO:0000151,GO:0005634,GO:0005635,GO:0006355,GO:0007275,GO:0007283,GO:0016363,GO:0030154,GO:0042802 ubiquitin ligase complex|nucleus|nuclear envelope|regulation of transcription, DNA-templated|multicellular organism development|spermatogenesis|nuclear matrix|cell differentiation|identical protein binding GMCL2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:64396,Genbank:NM_001358008.1,HGNC:HGNC:19717 germ cell-less, spermatogenesis associated 2 GO:0000151,GO:0005634,GO:0007275,GO:0007283,GO:0016363,GO:0016567,GO:0030154 ubiquitin ligase complex|nucleus|multicellular organism development|spermatogenesis|nuclear matrix|protein ubiquitination|cell differentiation GMDS 698.440914313521 738.726295492481 658.155533134562 0.890932862618346 -0.166611375168153 0.29712972524016 1 0.970652 1.24084 1.11578 0.90099 GeneID:2762,Genbank:NM_001500.3,HGNC:HGNC:4369,MIM:602884 GDP-mannose 4,6-dehydratase GO:0005737,GO:0005829,GO:0007219,GO:0008446,GO:0019673,GO:0042351,GO:0042802,GO:0070062,GO:0070401 cytoplasm|cytosol|Notch signaling pathway|GDP-mannose 4,6-dehydratase activity|GDP-mannose metabolic process|'de novo' GDP-L-fucose biosynthetic process|identical protein binding|extracellular exosome|NADP+ binding hsa00051,hsa00520 Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism GMEB1 376.076292520581 362.483039309049 389.669545732114 1.07500076824253 0.104337690828029 0.593003433251943 1 2.93866 3.29118 3.74642 3.13054 GeneID:10691,Genbank:NM_006582.3,HGNC:HGNC:4370,MIM:604409 glucocorticoid modulatory element binding protein 1 GO:0000978,GO:0001077,GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription from RNA polymerase II promoter|metal ion binding GMEB2 612.331361236186 581.579105600148 643.083616872224 1.10575433450039 0.145030897538364 0.387017396766758 1 5.05221 4.92127 5.60802 5.64175 GeneID:26205,Genbank:NM_012384.4,HGNC:HGNC:4371,MIM:607451 glucocorticoid modulatory element binding protein 2 GO:0000978,GO:0003713,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcription coactivator activity|nucleus|nucleoplasm|cytosol|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|metal ion binding GMFB 688.581884349957 797.040724321988 580.123044377926 0.727846177334808 -0.458294510733645 0.106056101379974 1 11.2066 8.5083 7.67048 6.75449 GeneID:2764,Genbank:NM_004124.2,HGNC:HGNC:4373,MIM:601713 glia maturation factor beta GO:0003779,GO:0004860,GO:0004871,GO:0005622,GO:0006468,GO:0007165,GO:0007399,GO:0007612,GO:0007626,GO:0008047,GO:0008083,GO:0034316,GO:0071933 actin binding|protein kinase inhibitor activity|signal transducer activity|intracellular|protein phosphorylation|signal transduction|nervous system development|learning|locomotory behavior|enzyme activator activity|growth factor activity|negative regulation of Arp2/3 complex-mediated actin nucleation|Arp2/3 complex binding GMFG 0.999152841887003 1.02816907859967 0.97013660517434 0.943557460895085 -0.0838177169406569 1 1 0.0723671 0.0657314 0.0677894 0 GeneID:9535,Genbank:NM_001301008.1,HGNC:HGNC:4374,MIM:604104 glia maturation factor gamma GO:0003779,GO:0004860,GO:0005576,GO:0006468,GO:0008047,GO:0008083,GO:0034316,GO:0034774,GO:0043312,GO:0071846,GO:0071933,GO:1904813,GO:2000249 actin binding|protein kinase inhibitor activity|extracellular region|protein phosphorylation|enzyme activator activity|growth factor activity|negative regulation of Arp2/3 complex-mediated actin nucleation|secretory granule lumen|neutrophil degranulation|actin filament debranching|Arp2/3 complex binding|ficolin-1-rich granule lumen|regulation of actin cytoskeleton reorganization GMIP 258.269829429611 244.666023087144 271.873635772077 1.11120306915375 0.152122489175272 0.472215337830812 1 2.21281 2.18017 2.38737 2.33277 GeneID:51291,Genbank:NM_001288998.1,HGNC:HGNC:24852,MIM:609694 GEM interacting protein GO:0005096,GO:0005622,GO:0005654,GO:0005829,GO:0005886,GO:0034260,GO:0035556,GO:0046872,GO:0051056 GTPase activator activity|intracellular|nucleoplasm|cytosol|plasma membrane|negative regulation of GTPase activity|intracellular signal transduction|metal ion binding|regulation of small GTPase mediated signal transduction GMNC 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0241594 0 GeneID:647309,Genbank:NM_001146686.2,HGNC:HGNC:40049,MIM:614448 geminin coiled-coil domain containing GO:0003682,GO:0005634,GO:0006270,GO:0007049,GO:0008283,GO:0060271 chromatin binding|nucleus|DNA replication initiation|cell cycle|cell proliferation|cilium assembly GMNN 1411.74281459767 1475.23052269178 1348.25510650355 0.913928423907239 -0.129846912664814 0.384959865062837 1 13.1153 12.918 12.4687 11.8183 GeneID:51053,Genbank:NM_015895.4,HGNC:HGNC:17493,MIM:602842 geminin, DNA replication inhibitor GO:0003682,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006461,GO:0008156,GO:0009887,GO:0035563,GO:0042826,GO:0045786,GO:0045892,GO:0070491,GO:0071163,GO:2000104 chromatin binding|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|cytosol|protein complex assembly|negative regulation of DNA replication|animal organ morphogenesis|positive regulation of chromatin binding|histone deacetylase binding|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|repressing transcription factor binding|DNA replication preinitiation complex assembly|negative regulation of DNA-dependent DNA replication GMPPA 967.365899507343 919.933993354554 1014.79780566013 1.10312023796366 0.141590050457656 0.364477635424783 1 16.5983 17.4838 19.9718 18.9841 GeneID:29926,Genbank:NM_013335.3,HGNC:HGNC:22923,MIM:615495 GDP-mannose pyrophosphorylase A GO:0005737,GO:0009058,GO:0016779,GO:0070062 cytoplasm|biosynthetic process|nucleotidyltransferase activity|extracellular exosome hsa00051,hsa00520 Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism GMPPB 1067.30754992919 993.385851717511 1141.22924814086 1.14882776533181 0.200162522329355 0.191469351443849 1 20.5744 22.9597 24.9184 26.9187 GeneID:29925,Genbank:NM_021971.2,HGNC:HGNC:22932,MIM:615320 GDP-mannose pyrophosphorylase B GO:0004475,GO:0005525,GO:0005737,GO:0005739,GO:0009298,GO:0070062 mannose-1-phosphate guanylyltransferase activity|GTP binding|cytoplasm|mitochondrion|GDP-mannose biosynthetic process|extracellular exosome hsa00051,hsa00520 Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism GMPR 828.092948673974 736.708174954858 919.477722393091 1.24808947918819 0.319721368938535 0.212220136646851 1 15.1633 15.4401 23.759 15.9033 GeneID:2766,Genbank:NM_006877.3,HGNC:HGNC:4376,MIM:139265 guanosine monophosphate reductase GO:0003920,GO:0005829,GO:0006144,GO:0009117,GO:0009409,GO:0043101,GO:0046872,GO:1902560 GMP reductase activity|cytosol|purine nucleobase metabolic process|nucleotide metabolic process|response to cold|purine-containing compound salvage|metal ion binding|GMP reductase complex hsa00230 Purine metabolism GMPR2 946.589175063548 878.393594047765 1014.78475607933 1.15527340244258 0.208234314560404 0.177572842657771 1 7.88664 7.7564 9.03639 9.00058 GeneID:51292,Genbank:NM_001351024.1,HGNC:HGNC:4377,MIM:610781 guanosine monophosphate reductase 2 GO:0003920,GO:0005829,GO:0006144,GO:0043101,GO:0046037,GO:0046872,GO:1902560 GMP reductase activity|cytosol|purine nucleobase metabolic process|purine-containing compound salvage|GMP metabolic process|metal ion binding|GMP reductase complex hsa00230 Purine metabolism GMPS 1344.03637775398 1418.25777855089 1269.81497695708 0.895334399825764 -0.159501477464634 0.291343165808073 1 6.18076 5.61624 5.96386 4.89499 GeneID:8833,Genbank:XM_011513263.2,HGNC:HGNC:4378,MIM:600358 guanine monophosphate synthase hsa00230,hsa00983 Purine metabolism|Drug metabolism - other enzymes GNA11 4018.73946398106 3548.86256813455 4488.61635982756 1.26480422209953 0.338914088741786 0.0126825035686921 0.462694708783992 35.9754 38.6235 49.2307 47.3603 GeneID:2767,Genbank:NM_002067.4,HGNC:HGNC:4379,MIM:139313 G protein subunit alpha 11 hsa04020,hsa04022,hsa04270,hsa04540,hsa04725,hsa04730,hsa04911,hsa04912,hsa04925,hsa04927,hsa04928,hsa04934,hsa05142,hsa05146,hsa05163,hsa05170,hsa05200 Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Gap junction|Cholinergic synapse|Long-term depression|Insulin secretion|GnRH signaling pathway|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Chagas disease (American trypanosomiasis)|Amoebiasis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNA12 3673.56076808941 3586.81552914591 3760.30600703291 1.04836894355933 0.0681465216208489 0.621081092137451 1 31.9021 32.5044 35.8593 32.9031 GeneID:2768,Genbank:NM_001293092.1,HGNC:HGNC:4380,MIM:604394 G protein subunit alpha 12 GO:0001701,GO:0003924,GO:0004871,GO:0005525,GO:0005737,GO:0005834,GO:0005886,GO:0005925,GO:0007186,GO:0007188,GO:0007266,GO:0007596,GO:0008360,GO:0010762,GO:0016328,GO:0030154,GO:0030168,GO:0031526,GO:0031683,GO:0031752,GO:0032006,GO:0032434,GO:0042493,GO:0042733,GO:0046872 in utero embryonic development|GTPase activity|signal transducer activity|GTP binding|cytoplasm|heterotrimeric G-protein complex|plasma membrane|focal adhesion|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|Rho protein signal transduction|blood coagulation|regulation of cell shape|regulation of fibroblast migration|lateral plasma membrane|cell differentiation|platelet activation|brush border membrane|G-protein beta/gamma-subunit complex binding|D5 dopamine receptor binding|regulation of TOR signaling|regulation of proteasomal ubiquitin-dependent protein catabolic process|response to drug|embryonic digit morphogenesis|metal ion binding hsa04010,hsa04022,hsa04071,hsa04072,hsa04270,hsa04730,hsa04810,hsa04928,hsa05163,hsa05200 MAPK signaling pathway|cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Vascular smooth muscle contraction|Long-term depression|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Human cytomegalovirus infection|Pathways in cancer GNA13 764.816262970879 789.922010012653 739.710515929105 0.936434871484661 -0.0947494355535602 0.79562755240974 1 4.94917 4.72637 5.87537 3.35094 GeneID:10672,Genbank:NM_006572.5,HGNC:HGNC:4381,MIM:604406 G protein subunit alpha 13 GO:0001569,GO:0001701,GO:0003924,GO:0004871,GO:0005085,GO:0005089,GO:0005525,GO:0005634,GO:0005829,GO:0005834,GO:0005886,GO:0005925,GO:0006928,GO:0007165,GO:0007186,GO:0007189,GO:0007204,GO:0007266,GO:0008360,GO:0016020,GO:0030154,GO:0030168,GO:0030334,GO:0031526,GO:0031584,GO:0031683,GO:0031702,GO:0031752,GO:0042470,GO:0043065,GO:0046872,GO:0051056,GO:0070062 branching involved in blood vessel morphogenesis|in utero embryonic development|GTPase activity|signal transducer activity|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|GTP binding|nucleus|cytosol|heterotrimeric G-protein complex|plasma membrane|focal adhesion|movement of cell or subcellular component|signal transduction|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|Rho protein signal transduction|regulation of cell shape|membrane|cell differentiation|platelet activation|regulation of cell migration|brush border membrane|activation of phospholipase D activity|G-protein beta/gamma-subunit complex binding|type 1 angiotensin receptor binding|D5 dopamine receptor binding|melanosome|positive regulation of apoptotic process|metal ion binding|regulation of small GTPase mediated signal transduction|extracellular exosome hsa04022,hsa04071,hsa04072,hsa04270,hsa04371,hsa04611,hsa04730,hsa04810,hsa04928,hsa05163,hsa05200 cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Platelet activation|Long-term depression|Regulation of actin cytoskeleton|Parathyroid hormone synthesis, secretion and action|Human cytomegalovirus infection|Pathways in cancer GNA14 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0.0156531 GeneID:9630,Genbank:NM_004297.3,HGNC:HGNC:4382,MIM:604397 G protein subunit alpha 14 GO:0001664,GO:0003924,GO:0004871,GO:0005525,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0007188,GO:0030168,GO:0031683,GO:0046872,GO:0060158,GO:0070062 G-protein coupled receptor binding|GTPase activity|signal transducer activity|GTP binding|heterotrimeric G-protein complex|plasma membrane|signal transduction|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|platelet activation|G-protein beta/gamma-subunit complex binding|metal ion binding|phospholipase C-activating dopamine receptor signaling pathway|extracellular exosome hsa04020,hsa05142,hsa05146 Calcium signaling pathway|Chagas disease (American trypanosomiasis)|Amoebiasis GNA15 0.974269732491135 0.980142803914724 0.968396661067546 0.988015886256305 -0.0173938558720137 1 1 0 0.0344537 0 0.0343873 GeneID:2769,Genbank:NM_002068.3,HGNC:HGNC:4383,MIM:139314 G protein subunit alpha 15 GO:0001664,GO:0003924,GO:0004871,GO:0005525,GO:0005834,GO:0005886,GO:0007186,GO:0007188,GO:0007202,GO:0007204,GO:0007207,GO:0030168,GO:0031683,GO:0046872,GO:0060158 G-protein coupled receptor binding|GTPase activity|signal transducer activity|GTP binding|heterotrimeric G-protein complex|plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway|platelet activation|G-protein beta/gamma-subunit complex binding|metal ion binding|phospholipase C-activating dopamine receptor signaling pathway hsa04020,hsa04926,hsa05142,hsa05146 Calcium signaling pathway|Relaxin signaling pathway|Chagas disease (American trypanosomiasis)|Amoebiasis GNAI1 649.775274783077 673.854573990477 625.695975575678 0.928532653374139 -0.106975449096511 0.525554381671035 1 7.98804 8.04985 8.41594 6.75513 GeneID:2770,Genbank:NM_002069.5,HGNC:HGNC:4384,MIM:139310 G protein subunit alpha i1 GO:0000287,GO:0001664,GO:0003924,GO:0004871,GO:0005525,GO:0005634,GO:0005730,GO:0005737,GO:0005765,GO:0005813,GO:0005834,GO:0005886,GO:0006457,GO:0007049,GO:0007186,GO:0007188,GO:0007193,GO:0019003,GO:0030496,GO:0031683,GO:0031821,GO:0032794,GO:0043434,GO:0043949,GO:0045121,GO:0050805,GO:0051301,GO:0060236,GO:0070062,GO:0099738,GO:1904322,GO:1904778 magnesium ion binding|G-protein coupled receptor binding|GTPase activity|signal transducer activity|GTP binding|nucleus|nucleolus|cytoplasm|lysosomal membrane|centrosome|heterotrimeric G-protein complex|plasma membrane|protein folding|cell cycle|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|GDP binding|midbody|G-protein beta/gamma-subunit complex binding|G-protein coupled serotonin receptor binding|GTPase activating protein binding|response to peptide hormone|regulation of cAMP-mediated signaling|membrane raft|negative regulation of synaptic transmission|cell division|regulation of mitotic spindle organization|extracellular exosome|cell cortex region|cellular response to forskolin|positive regulation of protein localization to cell cortex hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04261,hsa04360,hsa04371,hsa04540,hsa04611,hsa04670,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04914,hsa04915,hsa04916,hsa04921,hsa04923,hsa04924,hsa04926,hsa04928,hsa04934,hsa04971,hsa05012,hsa05030,hsa05032,hsa05034,hsa05133,hsa05142,hsa05145,hsa05163,hsa05170,hsa05200 Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Axon guidance|Apelin signaling pathway|Gap junction|Platelet activation|Leukocyte transendothelial migration|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Gastric acid secretion|Parkinson disease|Cocaine addiction|Morphine addiction|Alcoholism|Pertussis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNAI2 12374.3920502488 10631.1445339136 14117.639566584 1.32795105188801 0.409201970103596 0.00179284759279289 0.152615325462112 112.243 120.988 159.932 154.538 GeneID:2771,Genbank:NM_001282619.1,HGNC:HGNC:4385,MIM:139360 G protein subunit alpha i2 GO:0000186,GO:0001664,GO:0001973,GO:0003924,GO:0004871,GO:0005525,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005834,GO:0005886,GO:0006457,GO:0007049,GO:0007165,GO:0007186,GO:0007193,GO:0007194,GO:0007213,GO:0007214,GO:0007584,GO:0008283,GO:0008284,GO:0016020,GO:0030425,GO:0030496,GO:0031683,GO:0035556,GO:0044297,GO:0045121,GO:0046872,GO:0050805,GO:0051301,GO:0051924,GO:0070062,GO:1903561 activation of MAPKK activity|G-protein coupled receptor binding|adenosine receptor signaling pathway|GTPase activity|signal transducer activity|GTP binding|nucleoplasm|cytoplasm|centrosome|cytosol|heterotrimeric G-protein complex|plasma membrane|protein folding|cell cycle|signal transduction|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|G-protein coupled acetylcholine receptor signaling pathway|gamma-aminobutyric acid signaling pathway|response to nutrient|cell proliferation|positive regulation of cell proliferation|membrane|dendrite|midbody|G-protein beta/gamma-subunit complex binding|intracellular signal transduction|cell body|membrane raft|metal ion binding|negative regulation of synaptic transmission|cell division|regulation of calcium ion transport|extracellular exosome|extracellular vesicle hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04261,hsa04360,hsa04371,hsa04540,hsa04611,hsa04670,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04914,hsa04915,hsa04916,hsa04921,hsa04923,hsa04924,hsa04926,hsa04928,hsa04934,hsa04971,hsa05012,hsa05030,hsa05032,hsa05034,hsa05133,hsa05142,hsa05145,hsa05163,hsa05170,hsa05200 Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Axon guidance|Apelin signaling pathway|Gap junction|Platelet activation|Leukocyte transendothelial migration|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Gastric acid secretion|Parkinson disease|Cocaine addiction|Morphine addiction|Alcoholism|Pertussis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNAI3 1735.70198599045 1945.7565421472 1525.6474298337 0.784089579958498 -0.350909607410201 0.0150390212794856 0.511066130273729 19.5491 18.4136 15.8493 14.258 GeneID:2773,Genbank:NM_006496.3,HGNC:HGNC:4387,MIM:139370 G protein subunit alpha i3 GO:0001664,GO:0003924,GO:0004871,GO:0005525,GO:0005634,GO:0005730,GO:0005737,GO:0005765,GO:0005794,GO:0005813,GO:0005834,GO:0005886,GO:0006457,GO:0006810,GO:0006906,GO:0007049,GO:0007186,GO:0007193,GO:0007194,GO:0007212,GO:0016020,GO:0016239,GO:0019003,GO:0019904,GO:0030496,GO:0031683,GO:0031821,GO:0032794,GO:0042588,GO:0045121,GO:0046039,GO:0046872,GO:0051301,GO:0070062 G-protein coupled receptor binding|GTPase activity|signal transducer activity|GTP binding|nucleus|nucleolus|cytoplasm|lysosomal membrane|Golgi apparatus|centrosome|heterotrimeric G-protein complex|plasma membrane|protein folding|transport|vesicle fusion|cell cycle|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|dopamine receptor signaling pathway|membrane|positive regulation of macroautophagy|GDP binding|protein domain specific binding|midbody|G-protein beta/gamma-subunit complex binding|G-protein coupled serotonin receptor binding|GTPase activating protein binding|zymogen granule|membrane raft|GTP metabolic process|metal ion binding|cell division|extracellular exosome hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04261,hsa04360,hsa04371,hsa04540,hsa04611,hsa04670,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04914,hsa04915,hsa04916,hsa04921,hsa04923,hsa04924,hsa04926,hsa04928,hsa04934,hsa04971,hsa05012,hsa05030,hsa05032,hsa05034,hsa05133,hsa05142,hsa05145,hsa05163,hsa05170,hsa05200 Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Axon guidance|Apelin signaling pathway|Gap junction|Platelet activation|Leukocyte transendothelial migration|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Gastric acid secretion|Parkinson disease|Cocaine addiction|Morphine addiction|Alcoholism|Pertussis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNAL 156.90378377965 164.065007448674 149.742560110625 0.912702607577488 -0.13178324175916 0.616163085108958 1 0.699204 0.649212 0.602426 0.627251 GeneID:2774,Genbank:NM_182978.3,HGNC:HGNC:4388,MIM:139312 G protein subunit alpha L GO:0001664,GO:0003924,GO:0004871,GO:0005525,GO:0005834,GO:0005886,GO:0007165,GO:0007189,GO:0007190,GO:0007191,GO:0007193,GO:0007608,GO:0031683,GO:0046872,GO:0070062 G-protein coupled receptor binding|GTPase activity|signal transducer activity|GTP binding|heterotrimeric G-protein complex|plasma membrane|signal transduction|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of adenylate cyclase activity|adenylate cyclase-activating dopamine receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|sensory perception of smell|G-protein beta/gamma-subunit complex binding|metal ion binding|extracellular exosome hsa04020,hsa04728,hsa04740,hsa05012,hsa05142,hsa05146 Calcium signaling pathway|Dopaminergic synapse|Olfactory transduction|Parkinson disease|Chagas disease (American trypanosomiasis)|Amoebiasis GNAO1 564.806181873914 533.024836187647 596.587527560181 1.1192490237925 0.162531059925323 0.347702638811522 1 2.33132 2.46786 2.83193 2.61913 GeneID:2775,Genbank:NM_020988.2,HGNC:HGNC:4389,MIM:139311 G protein subunit alpha o1 GO:0003924,GO:0004871,GO:0005525,GO:0005834,GO:0005886,GO:0006457,GO:0006936,GO:0007188,GO:0007212,GO:0007223,GO:0007568,GO:0007626,GO:0008016,GO:0030425,GO:0030900,GO:0031175,GO:0031683,GO:0031821,GO:0031852,GO:0032794,GO:0034097,GO:0042542,GO:0043209,GO:0043278,GO:0043547,GO:0044297,GO:0046872,GO:0051430,GO:0051926 GTPase activity|signal transducer activity|GTP binding|heterotrimeric G-protein complex|plasma membrane|protein folding|muscle contraction|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|dopamine receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|aging|locomotory behavior|regulation of heart contraction|dendrite|forebrain development|neuron projection development|G-protein beta/gamma-subunit complex binding|G-protein coupled serotonin receptor binding|mu-type opioid receptor binding|GTPase activating protein binding|response to cytokine|response to hydrogen peroxide|myelin sheath|response to morphine|positive regulation of GTPase activity|cell body|metal ion binding|corticotropin-releasing hormone receptor 1 binding|negative regulation of calcium ion transport hsa04015,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04915,hsa04916,hsa04921,hsa04926,hsa05032,hsa05034,hsa05142,hsa05145,hsa05163,hsa05170 Rap1 signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Estrogen signaling pathway|Melanogenesis|Oxytocin signaling pathway|Relaxin signaling pathway|Morphine addiction|Alcoholism|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection GNAQ 499.57473845231 504.772165661789 494.377311242831 0.979406839112595 -0.0300198245917809 0.95663033174403 1 3.67662 2.69838 3.73764 2.6863 GeneID:2776,Genbank:NM_002072.4,HGNC:HGNC:4390,MIM:600998 G protein subunit alpha q GO:0001508,GO:0001750,GO:0003924,GO:0004871,GO:0005096,GO:0005525,GO:0005834,GO:0007189,GO:0007213,GO:0007215,GO:0007603,GO:0009649,GO:0016020,GO:0031683,GO:0031826,GO:0031965,GO:0046872,GO:0060158 action potential|photoreceptor outer segment|GTPase activity|signal transducer activity|GTPase activator activity|GTP binding|heterotrimeric G-protein complex|adenylate cyclase-activating G-protein coupled receptor signaling pathway|G-protein coupled acetylcholine receptor signaling pathway|glutamate receptor signaling pathway|phototransduction, visible light|entrainment of circadian clock|membrane|G-protein beta/gamma-subunit complex binding|type 2A serotonin receptor binding|nuclear membrane|metal ion binding|phospholipase C-activating dopamine receptor signaling pathway hsa04015,hsa04020,hsa04022,hsa04071,hsa04261,hsa04270,hsa04371,hsa04540,hsa04611,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04934,hsa04961,hsa04970,hsa04971,hsa04972,hsa05010,hsa05016,hsa05142,hsa05143,hsa05146,hsa05163,hsa05170,hsa05200 Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Huntington disease|Chagas disease (American trypanosomiasis)|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNAS 24123.421191327 23128.8312542967 25118.0111283573 1.0860043403054 0.119029869002827 0.362992517083524 1 112.261 113.101 123.365 126.193 GeneID:2778,Genbank:XM_017027821.1,HGNC:HGNC:4392,MIM:139320 GNAS complex locus GO:0003924,GO:0004871,GO:0005159,GO:0005525,GO:0005834,GO:0007191,GO:0007606,GO:0030819,GO:0031683,GO:0031698,GO:0031748,GO:0031852,GO:0035255,GO:0043547,GO:0043950,GO:0046872,GO:0051430,GO:0071880 GTPase activity|signal transducer activity|insulin-like growth factor receptor binding|GTP binding|heterotrimeric G-protein complex|adenylate cyclase-activating dopamine receptor signaling pathway|sensory perception of chemical stimulus|positive regulation of cAMP biosynthetic process|G-protein beta/gamma-subunit complex binding|beta-2 adrenergic receptor binding|D1 dopamine receptor binding|mu-type opioid receptor binding|ionotropic glutamate receptor binding|positive regulation of GTPase activity|positive regulation of cAMP-mediated signaling|metal ion binding|corticotropin-releasing hormone receptor 1 binding|adenylate cyclase-activating adrenergic receptor signaling pathway hsa01522,hsa04015,hsa04020,hsa04024,hsa04072,hsa04261,hsa04270,hsa04540,hsa04611,hsa04713,hsa04714,hsa04724,hsa04726,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04913,hsa04915,hsa04916,hsa04918,hsa04921,hsa04922,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04961,hsa04962,hsa04970,hsa04971,hsa04972,hsa04976,hsa05030,hsa05031,hsa05032,hsa05034,hsa05110,hsa05142,hsa05146,hsa05163,hsa05165,hsa05200,hsa05414 Endocrine resistance|Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Glutamatergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Vibrio cholerae infection|Chagas disease (American trypanosomiasis)|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Dilated cardiomyopathy (DCM) GNAT1 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0212152 0 0 0 GeneID:2779,Genbank:NM_144499.2,HGNC:HGNC:4393,MIM:139330 G protein subunit alpha transducin 1 hsa04744 Phototransduction GNAT2 3.97292484975714 4.55472144167109 3.3911282578432 0.744530329959987 -0.425597473760861 0.848163032438677 1 0.0430689 0.100015 0.0410368 0.0570545 GeneID:2780,Genbank:XM_011541264.2,HGNC:HGNC:4394,MIM:139340 G protein subunit alpha transducin 2 GO:0001580,GO:0001664,GO:0001750,GO:0001917,GO:0003924,GO:0004871,GO:0005525,GO:0005834,GO:0005886,GO:0006457,GO:0007186,GO:0007188,GO:0007204,GO:0007223,GO:0007601,GO:0007602,GO:0008020,GO:0009642,GO:0031683,GO:0042622,GO:0046549,GO:0046872,GO:0050908 detection of chemical stimulus involved in sensory perception of bitter taste|G-protein coupled receptor binding|photoreceptor outer segment|photoreceptor inner segment|GTPase activity|signal transducer activity|GTP binding|heterotrimeric G-protein complex|plasma membrane|protein folding|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|Wnt signaling pathway, calcium modulating pathway|visual perception|phototransduction|G-protein coupled photoreceptor activity|response to light intensity|G-protein beta/gamma-subunit complex binding|photoreceptor outer segment membrane|retinal cone cell development|metal ion binding|detection of light stimulus involved in visual perception hsa04744 Phototransduction GNAZ 83.1329974311624 64.9667570505188 101.299237811806 1.55924725830219 0.640849722161109 0.0447246478232877 0.787153801689864 0.148163 0.116772 0.230441 0.17069 GeneID:2781,Genbank:NM_002073.3,HGNC:HGNC:4395,MIM:139160 G protein subunit alpha z GO:0001664,GO:0003924,GO:0005057,GO:0005525,GO:0005635,GO:0005783,GO:0005829,GO:0005834,GO:0005886,GO:0006457,GO:0007186,GO:0007188,GO:0007193,GO:0030425,GO:0031683,GO:0031821,GO:0044297,GO:0046872,GO:0070062 G-protein coupled receptor binding|GTPase activity|signal transducer activity, downstream of receptor|GTP binding|nuclear envelope|endoplasmic reticulum|cytosol|heterotrimeric G-protein complex|plasma membrane|protein folding|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|dendrite|G-protein beta/gamma-subunit complex binding|G-protein coupled serotonin receptor binding|cell body|metal ion binding|extracellular exosome hsa04730 Long-term depression GNB1 15900.1476132252 15418.3261388364 16381.969087614 1.06249984207756 0.087462626818402 0.503749795299986 1 163.793 164.961 180.369 171.114 GeneID:2782,Genbank:NM_001282539.1,HGNC:HGNC:4396,MIM:139380 G protein subunit beta 1 GO:0003924,GO:0004871,GO:0005622,GO:0005834,GO:0007191,GO:0007200,GO:0008283,GO:0016020,GO:0032403,GO:0043209,GO:0050909,GO:0051020,GO:0060041,GO:0071380,GO:0071870,GO:0097381 GTPase activity|signal transducer activity|intracellular|heterotrimeric G-protein complex|adenylate cyclase-activating dopamine receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|cell proliferation|membrane|protein complex binding|myelin sheath|sensory perception of taste|GTPase binding|retina development in camera-type eye|cellular response to prostaglandin E stimulus|cellular response to catecholamine stimulus|photoreceptor disc membrane hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04744,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Phototransduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB1L 161.292033451487 170.445744329228 152.138322573745 0.892590913152279 -0.163928975298349 0.662091291852838 1 7.07055 7.01536 5.11361 8.05308 GeneID:54584,Genbank:NM_053004.2,HGNC:HGNC:4397,MIM:610778 G protein subunit beta 1 like GO:0005737,GO:0007186,GO:0009898,GO:0035176,GO:0035556 cytoplasm|G-protein coupled receptor signaling pathway|cytoplasmic side of plasma membrane|social behavior|intracellular signal transduction GNB2 8202.37122822952 8140.18170376383 8264.56075269521 1.01527964036403 0.0218771463284672 0.884660218810168 1 208.742 209.506 213.892 219.453 GeneID:2783,Genbank:NM_005273.3,HGNC:HGNC:4398,MIM:139390 G protein subunit beta 2 GO:0003924,GO:0004871,GO:0005246,GO:0005615,GO:0005765,GO:0005829,GO:0005886,GO:0005925,GO:0006457,GO:0007186,GO:0016020,GO:0031982,GO:0032403,GO:0043209,GO:0043234,GO:0044297,GO:0048471,GO:0051020,GO:0070062,GO:0071377 GTPase activity|signal transducer activity|calcium channel regulator activity|extracellular space|lysosomal membrane|cytosol|plasma membrane|focal adhesion|protein folding|G-protein coupled receptor signaling pathway|membrane|vesicle|protein complex binding|myelin sheath|protein complex|cell body|perinuclear region of cytoplasm|GTPase binding|extracellular exosome|cellular response to glucagon stimulus hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB3 28.925232730031 31.6811363378499 26.1693291222121 0.82602242682019 -0.27574714299683 0.613759787620833 1 0.282278 0.436604 0.4039 0.30153 GeneID:2784,Genbank:NM_002075.3,HGNC:HGNC:4400,MIM:139130 G protein subunit beta 3 GO:0003924,GO:0004871,GO:0005829,GO:0005886,GO:0006457,GO:0007186,GO:0008217,GO:0030425,GO:0030507,GO:0044297,GO:0051020,GO:0070062,GO:0071377 GTPase activity|signal transducer activity|cytosol|plasma membrane|protein folding|G-protein coupled receptor signaling pathway|regulation of blood pressure|dendrite|spectrin binding|cell body|GTPase binding|extracellular exosome|cellular response to glucagon stimulus hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04742,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Taste transduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB4 1019.90023621281 1128.01511508171 911.785357343914 0.808309520992427 -0.307020253774575 0.413886604632983 1 8.55801 7.00438 8.03442 4.70843 GeneID:59345,Genbank:NM_021629.3,HGNC:HGNC:20731,MIM:610863 G protein subunit beta 4 GO:0004871,GO:0005765,GO:0005829,GO:0006457,GO:0021762,GO:0032403,GO:0043209,GO:0070062,GO:0071377 signal transducer activity|lysosomal membrane|cytosol|protein folding|substantia nigra development|protein complex binding|myelin sheath|extracellular exosome|cellular response to glucagon stimulus hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNB5 1280.09953913218 1254.64564188545 1305.55343637892 1.04057543643715 0.0573815569317846 0.693349244426929 1 7.53392 7.07542 7.82458 7.84264 GeneID:10681,Genbank:NM_016194.3,HGNC:HGNC:4401,MIM:604447 G protein subunit beta 5 GO:0001750,GO:0001917,GO:0003924,GO:0004871,GO:0005096,GO:0005634,GO:0005829,GO:0005886,GO:0006457,GO:0007165,GO:0007212,GO:0031682,GO:0043209,GO:0043547,GO:0051087,GO:1901386,GO:1902773 photoreceptor outer segment|photoreceptor inner segment|GTPase activity|signal transducer activity|GTPase activator activity|nucleus|cytosol|plasma membrane|protein folding|signal transduction|dopamine receptor signaling pathway|G-protein gamma-subunit binding|myelin sheath|positive regulation of GTPase activity|chaperone binding|negative regulation of voltage-gated calcium channel activity|GTPase activator complex hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNE 1756.62449588756 1832.49628136868 1680.75271040644 0.917192971955772 -0.124702794660546 0.385113718319043 1 12.2311 12.2049 12.2225 10.595 GeneID:10020,Genbank:NM_001190388.1,HGNC:HGNC:23657,MIM:603824 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase GO:0004553,GO:0005524,GO:0005737,GO:0005829,GO:0006045,GO:0006047,GO:0006054,GO:0007155,GO:0008761,GO:0009384,GO:0046872 hydrolase activity, hydrolyzing O-glycosyl compounds|ATP binding|cytoplasm|cytosol|N-acetylglucosamine biosynthetic process|UDP-N-acetylglucosamine metabolic process|N-acetylneuraminate metabolic process|cell adhesion|UDP-N-acetylglucosamine 2-epimerase activity|N-acylmannosamine kinase activity|metal ion binding hsa00520 Amino sugar and nucleotide sugar metabolism GNG10 1.50986585944834 1.56626675524197 1.45346496365472 0.927980472541008 -0.107833647793846 1 1 32.772 28.219 27.9343 25.9977 GeneID:2790,Genbank:NM_001017998.3,HGNC:HGNC:4402,MIM:604389 G protein subunit gamma 10 GO:0003924,GO:0004871,GO:0005834,GO:0005886,GO:0007165,GO:0007186,GO:0070062,GO:0071377 GTPase activity|signal transducer activity|heterotrimeric G-protein complex|plasma membrane|signal transduction|G-protein coupled receptor signaling pathway|extracellular exosome|cellular response to glucagon stimulus hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG11 1790.55808096552 1627.2094752275 1953.90668670354 1.20077145349118 0.263961584606007 0.0649112862166158 0.901211712368954 78.356 86.1651 94.3765 102.962 GeneID:2791,Genbank:NM_004126.3,HGNC:HGNC:4403,MIM:604390 G protein subunit gamma 11 GO:0004871,GO:0005834,GO:0007186 signal transducer activity|heterotrimeric G-protein complex|G-protein coupled receptor signaling pathway hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG12 2958.40040260924 3189.47551736468 2727.32528785379 0.85510149647026 -0.22583242370311 0.244152068490078 1 31.4075 29.5043 30.3465 22.0492 GeneID:55970,Genbank:NM_018841.5,HGNC:HGNC:19663,MIM:615405 G protein subunit gamma 12 GO:0004871,GO:0005834,GO:0005884,GO:0005886,GO:0007165,GO:0007186,GO:0021987,GO:0030165,GO:0032496,GO:0042301,GO:0070062,GO:0071377 signal transducer activity|heterotrimeric G-protein complex|actin filament|plasma membrane|signal transduction|G-protein coupled receptor signaling pathway|cerebral cortex development|PDZ domain binding|response to lipopolysaccharide|phosphate ion binding|extracellular exosome|cellular response to glucagon stimulus hsa04010,hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04810,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Regulation of actin cytoskeleton|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG13 1.26483015846966 1.07619535328461 1.45346496365472 1.35055866875717 0.43355631240266 1 1 0 0 0.0360002 0 GeneID:51764,Genbank:NM_016541.2,HGNC:HGNC:14131,MIM:607298 G protein subunit gamma 13 GO:0004871,GO:0005834,GO:0005886,GO:0007200,GO:0030425,GO:0031681,GO:0050909,GO:0071377 signal transducer activity|heterotrimeric G-protein complex|plasma membrane|phospholipase C-activating G-protein coupled receptor signaling pathway|dendrite|G-protein beta-subunit binding|sensory perception of taste|cellular response to glucagon stimulus hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04742,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Taste transduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG2 256.856797185711 243.243835155956 270.469759215466 1.11192852654232 0.153064056301608 0.590948027938729 1 1.72725 1.73096 2.27848 1.46508 GeneID:54331,Genbank:XM_006720173.2,HGNC:HGNC:4404,MIM:606981 G protein subunit gamma 2 GO:0004871,GO:0005834,GO:0005886,GO:0006457,GO:0007186,GO:0007191,GO:0007223,GO:0008283,GO:0016020,GO:0030168,GO:0031681,GO:0070062,GO:0071377,GO:0071380,GO:0071870 signal transducer activity|heterotrimeric G-protein complex|plasma membrane|protein folding|G-protein coupled receptor signaling pathway|adenylate cyclase-activating dopamine receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|cell proliferation|membrane|platelet activation|G-protein beta-subunit binding|extracellular exosome|cellular response to glucagon stimulus|cellular response to prostaglandin E stimulus|cellular response to catecholamine stimulus hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG3 3.56033094522409 4.69880026572591 2.42186162472226 0.515421275168441 -0.956176005989165 0.630502196082564 1 0.0491391 0 0 0.0841675 GeneID:2785,Genbank:XM_006718500.2,HGNC:HGNC:4405,MIM:608941 G protein subunit gamma 3 GO:0004871,GO:0005834,GO:0007186,GO:0014069,GO:0030425,GO:0044297 signal transducer activity|heterotrimeric G-protein complex|G-protein coupled receptor signaling pathway|postsynaptic density|dendrite|cell body hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG4 58.0776516824215 84.1755942762258 31.9797090886173 0.379916641677332 -1.39624518641295 0.000258801407214955 0.0423952540726947 0.573078 0.650134 0.200738 0.293229 GeneID:2786,Genbank:NM_004485.3,HGNC:HGNC:4407,MIM:604388 G protein subunit gamma 4 GO:0004871,GO:0005834,GO:0005886,GO:0007186,GO:0008277,GO:0030308,GO:0070062,GO:0071377 signal transducer activity|heterotrimeric G-protein complex|plasma membrane|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|extracellular exosome|cellular response to glucagon stimulus hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG5 2727.17549623062 2804.33860871028 2650.01238375095 0.94496876216018 -0.0816614559467458 0.550846632119512 1 184.197 176.128 176.111 157.975 GeneID:2787,Genbank:NM_005274.2,HGNC:HGNC:4408,MIM:600874 G protein subunit gamma 5 GO:0004871,GO:0005739,GO:0005834,GO:0007186,GO:0016020,GO:0030165,GO:0031680,GO:0070062,GO:0072513,GO:2000179 signal transducer activity|mitochondrion|heterotrimeric G-protein complex|G-protein coupled receptor signaling pathway|membrane|PDZ domain binding|G-protein beta/gamma-subunit complex|extracellular exosome|positive regulation of secondary heart field cardioblast proliferation|positive regulation of neural precursor cell proliferation hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG7 216.083294449928 191.797163606396 240.36942529346 1.25324807089819 0.3256720134079 0.148599574723161 1 2.39222 2.67996 3.72348 3.97874 GeneID:2788,Genbank:XM_017026606.1,HGNC:HGNC:4410,MIM:604430 G protein subunit gamma 7 GO:0004871,GO:0005834,GO:0005886,GO:0007186,GO:0008277,GO:0070062,GO:0071377 signal transducer activity|heterotrimeric G-protein complex|plasma membrane|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|extracellular exosome|cellular response to glucagon stimulus hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNG8 0.729234031512454 0.490071401957362 0.968396661067546 1.97603177251261 0.982606144127986 1 1 0 0.0119213 0 0.0236104 GeneID:94235,Genbank:XM_017027505.1,HGNC:HGNC:19664 G protein subunit gamma 8 GO:0003924,GO:0004871,GO:0005834,GO:0005886,GO:0007186,GO:0007399,GO:0035176,GO:0043584,GO:0071377,GO:0071444 GTPase activity|signal transducer activity|heterotrimeric G-protein complex|plasma membrane|G-protein coupled receptor signaling pathway|nervous system development|social behavior|nose development|cellular response to glucagon stimulus|cellular response to pheromone hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNGT1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0596832 0 GeneID:2792,Genbank:NM_021955.4,HGNC:HGNC:4411,MIM:189970 G protein subunit gamma transducin 1 GO:0004871,GO:0005834,GO:0007186,GO:0007602,GO:0008104,GO:0042462 signal transducer activity|heterotrimeric G-protein complex|G-protein coupled receptor signaling pathway|phototransduction|protein localization|eye photoreceptor cell development hsa04014,hsa04062,hsa04151,hsa04371,hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04744,hsa04926,hsa05032,hsa05034,hsa05163,hsa05167,hsa05170,hsa05200 Ras signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Phototransduction|Relaxin signaling pathway|Morphine addiction|Alcoholism|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer GNL1 3136.95575837581 3062.35222950986 3211.55928724176 1.04872302287571 0.0686336995671202 0.619408249329989 1 12.9816 13.7257 14.1193 13.8594 GeneID:2794,Genbank:NM_005275.3,HGNC:HGNC:4413,MIM:143024 G protein nucleolar 1 (putative) GO:0002456,GO:0003924,GO:0005198,GO:0005525,GO:0005615,GO:0005634,GO:0006974,GO:0007165,GO:0042254 T cell mediated immunity|GTPase activity|structural molecule activity|GTP binding|extracellular space|nucleus|cellular response to DNA damage stimulus|signal transduction|ribosome biogenesis GNL2 980.544819902511 1093.5768637766 867.512776028419 0.793280111132303 -0.33409771623985 0.0457372606977415 0.79332376136203 10.6467 9.16025 8.52799 7.49432 GeneID:29889,Genbank:NM_001323624.1,HGNC:HGNC:29925,MIM:609365 G protein nucleolar 2 GO:0003723,GO:0003924,GO:0005525,GO:0005634,GO:0005730,GO:0016020,GO:0042254 RNA binding|GTPase activity|GTP binding|nucleus|nucleolus|membrane|ribosome biogenesis hsa03008 Ribosome biogenesis in eukaryotes GNL3 2437.25465972407 2879.72030971489 1994.78900973325 0.69270234439217 -0.529692538367251 0.000138060710669903 0.0281553232790469 39.9469 39.8153 29.3247 26.6001 GeneID:26354,Genbank:NM_206825.1,HGNC:HGNC:29931,MIM:608011 G protein nucleolar 3 GO:0003723,GO:0003924,GO:0005525,GO:0005615,GO:0005634,GO:0005730,GO:0008283,GO:0016020,GO:0016604,GO:0017145,GO:0019827,GO:0032206,GO:0033235,GO:0042127,GO:0042254,GO:0048027,GO:1902895,GO:1904816 RNA binding|GTPase activity|GTP binding|extracellular space|nucleus|nucleolus|cell proliferation|membrane|nuclear body|stem cell division|stem cell population maintenance|positive regulation of telomere maintenance|positive regulation of protein sumoylation|regulation of cell proliferation|ribosome biogenesis|mRNA 5'-UTR binding|positive regulation of pri-miRNA transcription from RNA polymerase II promoter|positive regulation of protein localization to chromosome, telomeric region hsa03008 Ribosome biogenesis in eukaryotes GNL3L 1089.52270931355 1136.65613787502 1042.38928075208 0.917066512921686 -0.124901721609698 0.410848930912124 1 5.27973 5.27817 4.74793 4.98761 GeneID:54552,Genbank:NM_001184819.1,HGNC:HGNC:25553,MIM:300873 G protein nucleolar 3 like GO:0003723,GO:0003924,GO:0005525,GO:0005634,GO:0005730,GO:0005829,GO:0016020,GO:0031397,GO:0031647,GO:0032091,GO:0032211,GO:0033234,GO:0042254,GO:0090073,GO:1904816 RNA binding|GTPase activity|GTP binding|nucleus|nucleolus|cytosol|membrane|negative regulation of protein ubiquitination|regulation of protein stability|negative regulation of protein binding|negative regulation of telomere maintenance via telomerase|negative regulation of protein sumoylation|ribosome biogenesis|positive regulation of protein homodimerization activity|positive regulation of protein localization to chromosome, telomeric region hsa03008 Ribosome biogenesis in eukaryotes GNMT 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 1.1898e-05 2.3855e-05 2.7425e-05 GeneID:27232,Genbank:NM_018960.5,HGNC:HGNC:4415,MIM:606628 glycine N-methyltransferase GO:0005542,GO:0005829,GO:0005977,GO:0006111,GO:0006464,GO:0006555,GO:0006730,GO:0016594,GO:0017174,GO:0034641,GO:0042802,GO:0046500,GO:0051289 folic acid binding|cytosol|glycogen metabolic process|regulation of gluconeogenesis|cellular protein modification process|methionine metabolic process|one-carbon metabolic process|glycine binding|glycine N-methyltransferase activity|cellular nitrogen compound metabolic process|identical protein binding|S-adenosylmethionine metabolic process|protein homotetramerization hsa00260 Glycine, serine and threonine metabolism GNPAT 1155.48246424853 1162.86903655133 1148.09589194573 0.987295951529149 -0.0184454835560618 0.918568725862506 1 15.1959 14.6836 15.4619 14.5814 GeneID:8443,Genbank:NM_014236.3,HGNC:HGNC:4416,MIM:602744 glyceronephosphate O-acyltransferase GO:0005102,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0006654,GO:0007416,GO:0007584,GO:0008611,GO:0016020,GO:0016287,GO:0016290,GO:0021587,GO:0030913,GO:0042493,GO:0042594,GO:0061024,GO:0070542 receptor binding|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|phosphatidic acid biosynthetic process|synapse assembly|response to nutrient|ether lipid biosynthetic process|membrane|glycerone-phosphate O-acyltransferase activity|palmitoyl-CoA hydrolase activity|cerebellum morphogenesis|paranodal junction assembly|response to drug|response to starvation|membrane organization|response to fatty acid hsa00564,hsa04146 Glycerophospholipid metabolism|Peroxisome GNPDA1 1748.85757992338 1553.40283263239 1944.31232721437 1.25164721369765 0.32382798497843 0.0244030547691566 0.624239560191094 19.3905 21.8485 26.6284 25.5141 GeneID:10007,Genbank:NM_005471.4,HGNC:HGNC:4417,MIM:601798 glucosamine-6-phosphate deaminase 1 GO:0004342,GO:0005737,GO:0005829,GO:0005975,GO:0006043,GO:0006044,GO:0006091,GO:0007338,GO:0070062 glucosamine-6-phosphate deaminase activity|cytoplasm|cytosol|carbohydrate metabolic process|glucosamine catabolic process|N-acetylglucosamine metabolic process|generation of precursor metabolites and energy|single fertilization|extracellular exosome hsa00520 Amino sugar and nucleotide sugar metabolism GNPDA2 222.420379548276 232.558316862264 212.282442234287 0.912813805579847 -0.13160748348539 0.568948826394133 1 4.07392 3.94146 4.27132 3.46066 GeneID:132789,Genbank:NM_001270881.1,HGNC:HGNC:21526,MIM:613222 glucosamine-6-phosphate deaminase 2 GO:0004342,GO:0005634,GO:0005829,GO:0005975,GO:0006043,GO:0006044 glucosamine-6-phosphate deaminase activity|nucleus|cytosol|carbohydrate metabolic process|glucosamine catabolic process|N-acetylglucosamine metabolic process hsa00520 Amino sugar and nucleotide sugar metabolism GNPNAT1 1009.41561972964 1161.43703996504 857.394199494253 0.738218405295619 -0.437880387515572 0.00437784852795965 0.261625455312693 11.6607 10.7705 9.89297 7.24442 GeneID:64841,Genbank:NM_198066.3,HGNC:HGNC:19980,MIM:616510 glucosamine-phosphate N-acetyltransferase 1 GO:0000139,GO:0001889,GO:0004343,GO:0005770,GO:0005793,GO:0005829,GO:0006041,GO:0006044,GO:0006048,GO:0010008,GO:0042802,GO:0048029,GO:1990830 Golgi membrane|liver development|glucosamine 6-phosphate N-acetyltransferase activity|late endosome|endoplasmic reticulum-Golgi intermediate compartment|cytosol|glucosamine metabolic process|N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|endosome membrane|identical protein binding|monosaccharide binding|cellular response to leukemia inhibitory factor hsa00520 Amino sugar and nucleotide sugar metabolism GNPTAB 668.921756100278 688.824239386237 649.019272814318 0.942213173846225 -0.0858745912515661 0.796907420404945 1 3.81417 3.21207 4.10868 2.6692 GeneID:79158,Genbank:NM_024312.4,HGNC:HGNC:29670,MIM:607840 N-acetylglucosamine-1-phosphate transferase alpha and beta subunits GO:0000139,GO:0003976,GO:0005509,GO:0005794,GO:0007040,GO:0016021,GO:0016256,GO:0033299,GO:0046835 Golgi membrane|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|calcium ion binding|Golgi apparatus|lysosome organization|integral component of membrane|N-glycan processing to lysosome|secretion of lysosomal enzymes|carbohydrate phosphorylation hsa04142 Lysosome GNPTG 804.320931732298 738.235207089668 870.406656374927 1.17903704404226 0.237609046915206 0.129861767196644 1 17.2336 14.9397 20.0061 19.1713 GeneID:84572,Genbank:NM_032520.4,HGNC:HGNC:23026,MIM:607838 N-acetylglucosamine-1-phosphate transferase gamma subunit GO:0000139,GO:0003976,GO:0005794,GO:0016256,GO:0042803,GO:0046835,GO:0070062 Golgi membrane|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|Golgi apparatus|N-glycan processing to lysosome|protein homodimerization activity|carbohydrate phosphorylation|extracellular exosome hsa04142 Lysosome GNRH1 18.4506785512522 16.5467578069645 20.3545992955398 1.23012613909007 0.298806259393066 0.668345909466898 1 0.360308 0.286248 0.387091 0.380732 GeneID:2796,Genbank:NM_001083111.1,HGNC:HGNC:4419,MIM:152760 gonadotropin releasing hormone 1 hsa04912 GnRH signaling pathway GNRH2 3.48035189811469 3.084507235799 3.87619656043037 1.25666638594424 0.32960170049408 0.933617934026868 1 0 0.0339345 0.0118724 0.0332768 GeneID:2797,Genbank:XM_017027823.1,HGNC:HGNC:4420,MIM:602352 gonadotropin releasing hormone 2 GO:0005179,GO:0005576,GO:0007165,GO:0007186,GO:0007275 hormone activity|extracellular region|signal transduction|G-protein coupled receptor signaling pathway|multicellular organism development hsa04912 GnRH signaling pathway GNRHR 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0152575 0 0 GeneID:2798,Genbank:NM_001012763.1,HGNC:HGNC:4421,MIM:138850 gonadotropin releasing hormone receptor GO:0004968,GO:0005886,GO:0005887,GO:0007186,GO:0007275,GO:0016020,GO:0042277,GO:0097211 gonadotropin-releasing hormone receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|multicellular organism development|membrane|peptide binding|cellular response to gonadotropin-releasing hormone hsa04080,hsa04912 Neuroactive ligand-receptor interaction|GnRH signaling pathway GNS 6197.08785391323 6236.01627684723 6158.15943097924 0.987514970710218 -0.0181254753121067 0.883879558752028 1 46.9218 49.6153 49.1598 47.0482 GeneID:2799,Genbank:NM_002076.3,HGNC:HGNC:4422,MIM:607664 glucosamine (N-acetyl)-6-sulfatase GO:0005576,GO:0006027,GO:0008449,GO:0008484,GO:0035578,GO:0042340,GO:0043202,GO:0043312,GO:0046872,GO:0070062,GO:1904813 extracellular region|glycosaminoglycan catabolic process|N-acetylglucosamine-6-sulfatase activity|sulfuric ester hydrolase activity|azurophil granule lumen|keratan sulfate catabolic process|lysosomal lumen|neutrophil degranulation|metal ion binding|extracellular exosome|ficolin-1-rich granule lumen hsa00531,hsa04142 Glycosaminoglycan degradation|Lysosome GOLGA1 565.40817004388 557.460762700614 573.355577387147 1.02851288512133 0.0405598679359682 0.830427434882677 1 3.19703 3.61373 3.92587 3.07491 GeneID:2800,Genbank:NM_002077.3,HGNC:HGNC:4424,MIM:602502 golgin A1 GO:0000139,GO:0001669,GO:0005794,GO:0005802,GO:0005829,GO:0048471 Golgi membrane|acrosomal vesicle|Golgi apparatus|trans-Golgi network|cytosol|perinuclear region of cytoplasm GOLGA2 2355.7458210251 2014.52245990211 2696.96918214809 1.33876352129583 0.420901146036549 0.00255905086537649 0.183792639730358 13.621 14.2918 19.6197 18.2219 GeneID:2801,Genbank:XM_005251931.1,HGNC:HGNC:4425,MIM:602580 golgin A2 GO:0000137,GO:0000139,GO:0000922,GO:0005794,GO:0005801,GO:0005874,GO:0006486,GO:0006888,GO:0007020,GO:0007098,GO:0008017,GO:0008356,GO:0010507,GO:0019901,GO:0019905,GO:0030134,GO:0032091,GO:0032580,GO:0033116,GO:0045296,GO:0048208,GO:0051225,GO:0051289,GO:0060050,GO:0061676,GO:0072686,GO:0090161,GO:0090166,GO:0090306,GO:0090307,GO:1904668 Golgi cis cisterna|Golgi membrane|spindle pole|Golgi apparatus|cis-Golgi network|microtubule|protein glycosylation|ER to Golgi vesicle-mediated transport|microtubule nucleation|centrosome cycle|microtubule binding|asymmetric cell division|negative regulation of autophagy|protein kinase binding|syntaxin binding|COPII-coated ER to Golgi transport vesicle|negative regulation of protein binding|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|cadherin binding|COPII vesicle coating|spindle assembly|protein homotetramerization|positive regulation of protein glycosylation|importin-alpha family protein binding|mitotic spindle|Golgi ribbon formation|Golgi disassembly|spindle assembly involved in meiosis|mitotic spindle assembly|positive regulation of ubiquitin protein ligase activity GOLGA3 2784.67699624557 2511.87591094963 3057.4780815415 1.21720904612107 0.283576960905267 0.0375313425888734 0.744558420459959 8.19202 7.95862 9.94588 9.93706 GeneID:2802,Genbank:NM_005895.3,HGNC:HGNC:4426,MIM:602581 golgin A3 GO:0000139,GO:0005215,GO:0005634,GO:0005654,GO:0005730,GO:0005794,GO:0005829,GO:0006891,GO:0007283,GO:0016020,GO:0017119,GO:0032580,GO:0045296,GO:0090498 Golgi membrane|transporter activity|nucleus|nucleoplasm|nucleolus|Golgi apparatus|cytosol|intra-Golgi vesicle-mediated transport|spermatogenesis|membrane|Golgi transport complex|Golgi cisterna membrane|cadherin binding|extrinsic component of Golgi membrane GOLGA4 170.007453818349 157.252034095956 182.762873540742 1.16222899494717 0.216894352155534 0.693400585812947 1 0.493198 0.426415 0.752532 0.326589 GeneID:2803,Genbank:NM_001172713.1,HGNC:HGNC:4427,MIM:602509 golgin A4 GO:0000139,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0016192,GO:0043001,GO:0043231,GO:0045773,GO:0051020,GO:0070062 Golgi membrane|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|vesicle-mediated transport|Golgi to plasma membrane protein transport|intracellular membrane-bounded organelle|positive regulation of axon extension|GTPase binding|extracellular exosome GOLGA5 503.115450579599 511.422459881091 494.808441278108 0.96751410056014 -0.0476454076251993 0.816090957206488 1 6.15387 5.32115 5.71344 5.29624 GeneID:9950,Genbank:NM_005113.3,HGNC:HGNC:4428,MIM:606918 golgin A5 GO:0000139,GO:0000301,GO:0005794,GO:0005801,GO:0007030,GO:0016020,GO:0016021,GO:0017137,GO:0030133,GO:0031985,GO:0042803,GO:0048193 Golgi membrane|retrograde transport, vesicle recycling within Golgi|Golgi apparatus|cis-Golgi network|Golgi organization|membrane|integral component of membrane|Rab GTPase binding|transport vesicle|Golgi cisterna|protein homodimerization activity|Golgi vesicle transport GOLGA6L10 1.48084962273568 0.538097676642304 2.42360156882906 4.50401790238564 2.17121256179462 0.55094696455999 1 0.00870372 0 0.0251129 0.0156347 GeneID:647042,Genbank:NM_001164465.3,HGNC:HGNC:37228 golgin A6 family-like 10 GO:0005794 Golgi apparatus GOLGA6L3 1.26570013052306 1.07619535328461 1.45520490776151 1.35217542365347 0.435282330922931 1 1 0.0329307 0 0.0156654 0 GeneID:100133220,Genbank:NM_001310153.1,HGNC:HGNC:37441 golgin A6 family-like 3 GO:0005794 Golgi apparatus GOLGA6L4 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0.00846593 0.0080993 0.00813176 0.00760384 GeneID:643707,Genbank:NM_001267536.2,HGNC:HGNC:27256 golgin A6 family-like 4 GO:0005794 Golgi apparatus GOLGA6L9 70.0598976870018 76.1325380910603 63.9872572829434 0.840471878218611 -0.250728546494675 0.527396937331639 1 0.559647 0.487691 0.60423 0.27847 GeneID:440295,Genbank:XM_017022226.1,HGNC:HGNC:37229 golgin A6 family-like 9 GO:0005794 Golgi apparatus GOLGA7 1550.61275225437 1583.33133776795 1517.89416674078 0.958671208314862 -0.0608919902452572 0.702914390649941 1 32.1742 27.2844 30.2791 26.6091 GeneID:51125,Genbank:XM_024447174.1,HGNC:HGNC:24876,MIM:609453 golgin A7 GO:0002178,GO:0005795,GO:0006612,GO:0018230,GO:0031228,GO:0043001,GO:0050821 palmitoyltransferase complex|Golgi stack|protein targeting to membrane|peptidyl-L-cysteine S-palmitoylation|intrinsic component of Golgi membrane|Golgi to plasma membrane protein transport|protein stabilization GOLGA7B 8.0171275059634 8.76345030543964 7.27080470648717 0.829673753267482 -0.269383947669957 0.85693241180282 1 0.0617229 0.0436554 0.0584336 0.0363229 GeneID:401647,Genbank:NM_001010917.2,HGNC:HGNC:31668,MIM:614189 golgin A7 family member B GO:0000139,GO:0002178,GO:0006612,GO:0018230,GO:0072659 Golgi membrane|palmitoyltransferase complex|protein targeting to membrane|peptidyl-L-cysteine S-palmitoylation|protein localization to plasma membrane GOLGA8A 40.1074853316849 42.404872251119 37.8100984122508 0.891645143707585 -0.165458433253456 0.724168480445523 1 0.522069 0.477214 0.581534 0.366675 GeneID:23015,Genbank:NM_181077.3,HGNC:HGNC:31972,MIM:616180 golgin A8 family member A GO:0005794,GO:0005829,GO:0032580 Golgi apparatus|cytosol|Golgi cisterna membrane GOLGA8B 250.443602897252 297.813231560893 203.073974233612 0.681883652950087 -0.55240249585959 0.00986431505514109 0.395250236220769 1.61901 1.31253 1.24713 0.896124 GeneID:440270,Genbank:XM_017022214.1,HGNC:HGNC:31973,MIM:609619 golgin A8 family member B GO:0005794,GO:0005829,GO:0032580 Golgi apparatus|cytosol|Golgi cisterna membrane GOLGA8H 18.3732010538279 15.422536178995 21.3238659286607 1.38264327482682 0.467428985828622 0.497731700279586 1 0.0910141 0.10824 0.116244 0.115031 GeneID:728498,Genbank:NM_001282490.1,HGNC:HGNC:37443 golgin A8 family member H GO:0005794 Golgi apparatus GOLGA8J 1.24669009255078 2.00831188251439 0.48506830258717 0.241530365283637 -2.04972351828911 0.634396538962021 1 0.00676935 0 0.00646839 0 GeneID:653073,Genbank:XM_011521950.2,HGNC:HGNC:38650 golgin A8 family member J GO:0005794 Golgi apparatus GOLGA8K 2.22639791043881 3.96859749034384 0.484198330533773 0.122007417409273 -3.03495923616245 0.285827611520371 1 0.00769974 0.0219916 0 0.00686753 GeneID:653125,Genbank:NM_001282493.1,HGNC:HGNC:38652 golgin A8 family member K GO:0005794 Golgi apparatus GOLGA8M 1.94734287337727 1.47021420587209 2.42447154088245 1.64906006974972 0.721643952293634 0.892100481787535 1 0 0.0104487 0.00352882 0 GeneID:653720,Genbank:NM_001282468.1,HGNC:HGNC:44404 golgin A8 family member M GO:0005794 Golgi apparatus GOLGA8N 4.98815119390463 4.16070258908361 5.81559979872566 1.39774465350732 0.483100826545973 0.772947985614534 1 0.0452397 0.0143547 0.0144474 0.0403805 GeneID:643699,Genbank:NM_001282494.1,HGNC:HGNC:44405 golgin A8 family member N GO:0005794 Golgi apparatus GOLGA8O 6.20506344416445 4.65077399104097 7.75935289728793 1.66840033771479 0.738465509367711 0.664894653771017 1 0.0222777 0.0210712 0.0426153 0 GeneID:728047,Genbank:NM_001277308.1,HGNC:HGNC:44406 golgin A8 family member O GO:0005794 Golgi apparatus GOLGA8R 3.74320104546065 2.15239070656922 5.33401138435208 2.47817989924988 1.30928092126988 0.497909444710297 1 0.0310244 0 0.0667715 0.0138245 GeneID:101059918,Genbank:NM_001282484.1,HGNC:HGNC:44407 golgin A8 family member R GO:0005794 Golgi apparatus GOLGA8S 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0126146 GeneID:653061,Genbank:NM_001355465.1,HGNC:HGNC:44409 golgin A8 family member S GO:0005794 Golgi apparatus GOLGA8T 4.55741722345269 5.23689794236822 3.87793650453717 0.740502592797044 -0.433423307909514 0.85026060611622 1 0.00678083 0.0255077 0.0258938 0 GeneID:653075,Genbank:XM_024450035.1,HGNC:HGNC:44410 golgin A8 family member T GO:0032580 Golgi cisterna membrane GOLGB1 135.326151161785 118.921620539659 151.730681783911 1.27588811097062 0.351501817484016 0.47951912550718 1 0.258674 0.224111 0.396985 0.207234 GeneID:2804,Genbank:NM_004487.4,HGNC:HGNC:4429,MIM:602500 golgin B1 GO:0000139,GO:0003700,GO:0003723,GO:0005793,GO:0005794,GO:0005795,GO:0005801,GO:0006888,GO:0007030,GO:0016020,GO:0016021,GO:0043565,GO:1905793 Golgi membrane|DNA binding transcription factor activity|RNA binding|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|Golgi stack|cis-Golgi network|ER to Golgi vesicle-mediated transport|Golgi organization|membrane|integral component of membrane|sequence-specific DNA binding|protein localization to pericentriolar material GOLIM4 1117.80720412389 1157.15085886126 1078.46354938653 0.931999091672311 -0.101599546059836 0.70088410191403 1 7.46334 6.89546 8.03929 5.47089 GeneID:27333,Genbank:NM_001308155.1,HGNC:HGNC:15448,MIM:606805 golgi integral membrane protein 4 GO:0000139,GO:0005794,GO:0005796,GO:0005801,GO:0010008,GO:0016020,GO:0016021,GO:0030133,GO:0030139,GO:0032580 Golgi membrane|Golgi apparatus|Golgi lumen|cis-Golgi network|endosome membrane|membrane|integral component of membrane|transport vesicle|endocytic vesicle|Golgi cisterna membrane GOLM1 1368.35278194828 1362.68963903268 1374.01592486388 1.00831171347222 0.0119417082437895 0.927473155586397 1 13.5576 13.1101 14.9064 12.0651 GeneID:51280,Genbank:NM_177937.2,HGNC:HGNC:15451,MIM:606804 golgi membrane protein 1 GO:0005615,GO:0005788,GO:0005794,GO:0005887,GO:0006997,GO:0019216,GO:0043687,GO:0044267,GO:0070062 extracellular space|endoplasmic reticulum lumen|Golgi apparatus|integral component of plasma membrane|nucleus organization|regulation of lipid metabolic process|post-translational protein modification|cellular protein metabolic process|extracellular exosome GOLPH3 2547.70465164234 2566.49435063011 2528.91495265457 0.985357693085781 -0.0212805648707422 0.882250792713943 1 37.017 37.6082 40.1432 34.2904 GeneID:64083,Genbank:XM_017009686.2,HGNC:HGNC:15452,MIM:612207 golgi phosphoprotein 3 GO:0005739,GO:0005758,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006890,GO:0007030,GO:0008283,GO:0009101,GO:0009306,GO:0010467,GO:0010821,GO:0016477,GO:0019899,GO:0030032,GO:0031985,GO:0032008,GO:0032580,GO:0043001,GO:0043066,GO:0043231,GO:0045053,GO:0048194,GO:0050714,GO:0050901,GO:0060352,GO:0070273,GO:0090161,GO:0090164 mitochondrion|mitochondrial intermembrane space|endosome|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|retrograde vesicle-mediated transport, Golgi to ER|Golgi organization|cell proliferation|glycoprotein biosynthetic process|protein secretion|gene expression|regulation of mitochondrion organization|cell migration|enzyme binding|lamellipodium assembly|Golgi cisterna|positive regulation of TOR signaling|Golgi cisterna membrane|Golgi to plasma membrane protein transport|negative regulation of apoptotic process|intracellular membrane-bounded organelle|protein retention in Golgi apparatus|Golgi vesicle budding|positive regulation of protein secretion|leukocyte tethering or rolling|cell adhesion molecule production|phosphatidylinositol-4-phosphate binding|Golgi ribbon formation|asymmetric Golgi ribbon formation GOLPH3L 546.390851623833 573.708537203506 519.073166044161 0.904768070167369 -0.144380078274057 0.4149459128737 1 4.54416 4.39014 4.63373 3.87507 GeneID:55204,Genbank:NM_018178.5,HGNC:HGNC:24882,MIM:612208 golgi phosphoprotein 3 like GO:0000139,GO:0005802,GO:0005829,GO:0006890,GO:0007030,GO:0031985,GO:0032580,GO:0032588,GO:0043001,GO:0048194,GO:0050714,GO:0070273 Golgi membrane|trans-Golgi network|cytosol|retrograde vesicle-mediated transport, Golgi to ER|Golgi organization|Golgi cisterna|Golgi cisterna membrane|trans-Golgi network membrane|Golgi to plasma membrane protein transport|Golgi vesicle budding|positive regulation of protein secretion|phosphatidylinositol-4-phosphate binding GOLT1A 12.8629173190663 9.253521707397 16.4723129307356 1.7801128534197 0.83196870630849 0.309432818183274 1 0.532636 0.475572 0.429387 0.801892 GeneID:127845,Genbank:XM_017000314.1,HGNC:HGNC:24766 golgi transport 1A GO:0000137,GO:0000139,GO:0005635,GO:0005783,GO:0005802,GO:0006888,GO:0015031,GO:0016021 Golgi cis cisterna|Golgi membrane|nuclear envelope|endoplasmic reticulum|trans-Golgi network|ER to Golgi vesicle-mediated transport|protein transport|integral component of membrane GOLT1B 579.137780579065 595.578436847101 562.69712431103 0.944790962026532 -0.0819329310645155 0.670525645867842 1 10.0598 8.9868 10.0717 8.12774 GeneID:51026,Genbank:XM_024448999.1,HGNC:HGNC:20175,MIM:615078 golgi transport 1B GO:0000139,GO:0004871,GO:0005783,GO:0015031,GO:0016020,GO:0016021,GO:0016192,GO:0043123 Golgi membrane|signal transducer activity|endoplasmic reticulum|protein transport|membrane|integral component of membrane|vesicle-mediated transport|positive regulation of I-kappaB kinase/NF-kappaB signaling GON4L 950.396618053587 1024.54749068808 876.245745419094 0.855251467973059 -0.225579419617502 0.141784336065297 1 2.63956 2.69607 2.48986 2.08707 GeneID:54856,Genbank:NM_001282856.1,HGNC:HGNC:25973,MIM:610393 gon-4 like GON7 256.154300654682 250.152861058044 262.155740251319 1.0479821783469 0.0676141830689114 0.758615044972183 1 7.83835 8.46176 7.68311 9.14589 GeneID:84520,Genbank:NM_032490.4,HGNC:HGNC:20356,MIM:617436 GON7, KEOPS complex subunit GO:0000408,GO:0005634 EKC/KEOPS complex|nucleus GOPC 954.566177370465 1061.86630147343 847.2660532675 0.7979027605376 -0.325715157259459 0.303369326450301 1 9.91582 8.00544 8.65379 5.66559 GeneID:57120,Genbank:NM_001017408.2,HGNC:HGNC:17643,MIM:606845 golgi associated PDZ and coiled-coil motif containing GO:0000139,GO:0005109,GO:0005737,GO:0005765,GO:0005794,GO:0005886,GO:0006888,GO:0006893,GO:0007289,GO:0008022,GO:0010360,GO:0014069,GO:0015031,GO:0016020,GO:0030054,GO:0030140,GO:0030425,GO:0030660,GO:0030695,GO:0042803,GO:0043004,GO:0043234,GO:0044325,GO:0045176,GO:0045211,GO:0051260,GO:2000009 Golgi membrane|frizzled binding|cytoplasm|lysosomal membrane|Golgi apparatus|plasma membrane|ER to Golgi vesicle-mediated transport|Golgi to plasma membrane transport|spermatid nucleus differentiation|protein C-terminus binding|negative regulation of anion channel activity|postsynaptic density|protein transport|membrane|cell junction|trans-Golgi network transport vesicle|dendrite|Golgi-associated vesicle membrane|GTPase regulator activity|protein homodimerization activity|cytoplasmic sequestering of CFTR protein|protein complex|ion channel binding|apical protein localization|postsynaptic membrane|protein homooligomerization|negative regulation of protein localization to cell surface GORAB 158.000415401656 169.638089313837 146.362741489476 0.86279409348156 -0.212911794761306 0.413211675427811 1 1.3235 1.21205 1.27811 1.10236 GeneID:92344,Genbank:NM_001320252.1,HGNC:HGNC:25676,MIM:607983 golgin, RAB6 interacting GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0031069,GO:1901622,GO:1905515 nucleus|nucleoplasm|nucleolus|cytoplasm|Golgi apparatus|cytosol|hair follicle morphogenesis|positive regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|non-motile cilium assembly hsa04115 p53 signaling pathway GORASP1 1015.66856254581 930.821425402094 1100.51569968952 1.18230593930959 0.241603402701044 0.11909030948179 1 6.50634 6.99817 7.61588 8.74718 GeneID:64689,Genbank:NM_031899.3,HGNC:HGNC:16769,MIM:606867 golgi reassembly stacking protein 1 GO:0000139,GO:0005794,GO:0006487,GO:0006888,GO:0007030,GO:0015031,GO:0033116,GO:0048208,GO:0050774,GO:1904668 Golgi membrane|Golgi apparatus|protein N-linked glycosylation|ER to Golgi vesicle-mediated transport|Golgi organization|protein transport|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating|negative regulation of dendrite morphogenesis|positive regulation of ubiquitin protein ligase activity GORASP2 2172.8903531315 2179.58722746491 2166.1934787981 0.99385491505087 -0.00889283526666864 0.937506904020545 1 26.4023 28.6507 26.7827 28.4399 GeneID:26003,Genbank:NM_001201428.1,HGNC:HGNC:17500,MIM:608693 golgi reassembly stacking protein 2 GO:0000139,GO:0005794,GO:0006996,GO:0007030,GO:0016020 Golgi membrane|Golgi apparatus|organelle organization|Golgi organization|membrane GOSR1 1430.45403643014 1469.96521578494 1390.94285707533 0.946242021334214 -0.0797188644707274 0.593909004724525 1 9.34724 9.22075 9.45499 8.12471 GeneID:9527,Genbank:XM_005258072.3,HGNC:HGNC:4430,MIM:604026 golgi SNAP receptor complex member 1 GO:0000139,GO:0005484,GO:0005801,GO:0005829,GO:0006888,GO:0015031,GO:0016021,GO:0042147 Golgi membrane|SNAP receptor activity|cis-Golgi network|cytosol|ER to Golgi vesicle-mediated transport|protein transport|integral component of membrane|retrograde transport, endosome to Golgi hsa04130 SNARE interactions in vesicular transport GOSR2 2098.54059711306 2023.50642427075 2173.57476995537 1.07416252495403 0.103212295191009 0.467006312171116 1 5.76126 6.11744 6.83236 6.22946 GeneID:9570,Genbank:XM_017025386.1,HGNC:HGNC:4431,MIM:604027 golgi SNAP receptor complex member 2 GO:0000139,GO:0000149,GO:0005484,GO:0005789,GO:0005794,GO:0005829,GO:0006623,GO:0006888,GO:0006891,GO:0006896,GO:0012507,GO:0016020,GO:0016021,GO:0031201,GO:0031902,GO:0033116,GO:0036498,GO:0042147,GO:0048208,GO:0048280 Golgi membrane|SNARE binding|SNAP receptor activity|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein targeting to vacuole|ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi to vacuole transport|ER to Golgi transport vesicle membrane|membrane|integral component of membrane|SNARE complex|late endosome membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|IRE1-mediated unfolded protein response|retrograde transport, endosome to Golgi|COPII vesicle coating|vesicle fusion with Golgi apparatus hsa04130 SNARE interactions in vesicular transport GOT1 2479.34314650297 2341.83602812981 2616.85026487613 1.11743530863941 0.160191312297529 0.251616127494241 1 36.8315 38.5176 41.1103 44.3182 GeneID:2805,Genbank:NM_002079.2,HGNC:HGNC:4432,MIM:138180 glutamic-oxaloacetic transaminase 1 GO:0004069,GO:0004609,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005829,GO:0006094,GO:0006103,GO:0006107,GO:0006114,GO:0006531,GO:0006532,GO:0006533,GO:0006536,GO:0007219,GO:0008652,GO:0019550,GO:0019551,GO:0030170,GO:0031406,GO:0032869,GO:0043679,GO:0047801,GO:0051384,GO:0055089,GO:0070062,GO:0080130 L-aspartate:2-oxoglutarate aminotransferase activity|phosphatidylserine decarboxylase activity|nucleus|nucleoplasm|cytoplasm|lysosome|cytosol|gluconeogenesis|2-oxoglutarate metabolic process|oxaloacetate metabolic process|glycerol biosynthetic process|aspartate metabolic process|aspartate biosynthetic process|aspartate catabolic process|glutamate metabolic process|Notch signaling pathway|cellular amino acid biosynthetic process|glutamate catabolic process to aspartate|glutamate catabolic process to 2-oxoglutarate|pyridoxal phosphate binding|carboxylic acid binding|cellular response to insulin stimulus|axon terminus|L-cysteine:2-oxoglutarate aminotransferase activity|response to glucocorticoid|fatty acid homeostasis|extracellular exosome|L-phenylalanine:2-oxoglutarate aminotransferase activity hsa00220,hsa00250,hsa00270,hsa00330,hsa00350,hsa00360,hsa00400 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Cysteine and methionine metabolism|Arginine and proline metabolism|Tyrosine metabolism|Phenylalanine metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis GOT2 6183.18546415887 6324.60353074193 6041.76739757581 0.955280021618535 -0.0660044019647817 0.606514028737457 1 97.999 104.077 98.7681 97.1105 GeneID:2806,Genbank:NM_001286220.1,HGNC:HGNC:4433,MIM:138150 glutamic-oxaloacetic transaminase 2 GO:0003723,GO:0004069,GO:0005543,GO:0005739,GO:0005743,GO:0005759,GO:0005886,GO:0006094,GO:0006103,GO:0006107,GO:0006531,GO:0006532,GO:0006533,GO:0006536,GO:0008652,GO:0009986,GO:0015908,GO:0016212,GO:0016597,GO:0019470,GO:0019550,GO:0019551,GO:0019899,GO:0030170,GO:0042803,GO:0043204,GO:0043209,GO:0043234,GO:0045471,GO:0046487,GO:0047578,GO:0070062,GO:0080130 RNA binding|L-aspartate:2-oxoglutarate aminotransferase activity|phospholipid binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|plasma membrane|gluconeogenesis|2-oxoglutarate metabolic process|oxaloacetate metabolic process|aspartate metabolic process|aspartate biosynthetic process|aspartate catabolic process|glutamate metabolic process|cellular amino acid biosynthetic process|cell surface|fatty acid transport|kynurenine-oxoglutarate transaminase activity|amino acid binding|4-hydroxyproline catabolic process|glutamate catabolic process to aspartate|glutamate catabolic process to 2-oxoglutarate|enzyme binding|pyridoxal phosphate binding|protein homodimerization activity|perikaryon|myelin sheath|protein complex|response to ethanol|glyoxylate metabolic process|4-hydroxyglutamate transaminase activity|extracellular exosome|L-phenylalanine:2-oxoglutarate aminotransferase activity hsa00220,hsa00250,hsa00270,hsa00330,hsa00350,hsa00360,hsa00400,hsa04975 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism|Cysteine and methionine metabolism|Arginine and proline metabolism|Tyrosine metabolism|Phenylalanine metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis|Fat digestion and absorption GP1BA 1.97679409611663 2.49838328447175 1.45520490776151 0.582458631069969 -0.77977250841594 0.825694118379557 1 0.0143855 0.0253735 0.040083 0 GeneID:2811,Genbank:NM_000173.6,HGNC:HGNC:4439,MIM:606672 glycoprotein Ib platelet alpha subunit hsa04512,hsa04611,hsa04640 ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage GP1BB 22.6958295289725 26.4922646701666 18.8993943877783 0.713392932732596 -0.487231171151799 0.416111939495872 1 1.88973 2.40003 1.58901 1.92882 GeneID:2812,Genbank:NM_000407.4,HGNC:HGNC:4440,MIM:138720 glycoprotein Ib platelet beta subunit GO:0004888,GO:0005886,GO:0005887,GO:0007155,GO:0007166,GO:0007596,GO:0007597,GO:0030168,GO:0042802 transmembrane signaling receptor activity|plasma membrane|integral component of plasma membrane|cell adhesion|cell surface receptor signaling pathway|blood coagulation|blood coagulation, intrinsic pathway|platelet activation|identical protein binding hsa04512,hsa04611,hsa04640 ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage GP5 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0390966 0 0 0 GeneID:2814,Genbank:NM_004488.2,HGNC:HGNC:4443,MIM:173511 glycoprotein V platelet GO:0005578,GO:0005615,GO:0005886,GO:0005887,GO:0007155,GO:0007409,GO:0007596,GO:0007597,GO:0030168,GO:0070062 proteinaceous extracellular matrix|extracellular space|plasma membrane|integral component of plasma membrane|cell adhesion|axonogenesis|blood coagulation|blood coagulation, intrinsic pathway|platelet activation|extracellular exosome hsa04512,hsa04611,hsa04640 ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage GP6 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:51206,Genbank:NM_001256017.2,HGNC:HGNC:14388,MIM:605546 glycoprotein VI platelet GO:0004872,GO:0004888,GO:0005518,GO:0005886,GO:0005887,GO:0007167,GO:0007596,GO:0009986,GO:0030168,GO:0050900,GO:0070062,GO:0097197 receptor activity|transmembrane signaling receptor activity|collagen binding|plasma membrane|integral component of plasma membrane|enzyme linked receptor protein signaling pathway|blood coagulation|cell surface|platelet activation|leukocyte migration|extracellular exosome|tetraspanin-enriched microdomain hsa04512,hsa04611 ECM-receptor interaction|Platelet activation GPA33 0.974704718517834 0.980142803914724 0.969266633120943 0.98890348350226 -0.0160983733645535 1 1 0 0.026146 0.0136717 0.0127952 GeneID:10223,Genbank:NM_005814.2,HGNC:HGNC:4445,MIM:602171 glycoprotein A33 GPAA1 1963.65944987646 1645.7087439889 2281.61015576403 1.38639972844394 0.471343277028049 0.000962992471840078 0.100805800189482 45.7068 49.3376 68.679 67.1521 GeneID:8733,Genbank:NM_003801.3,HGNC:HGNC:4446,MIM:603048 glycosylphosphatidylinositol anchor attachment 1 GO:0005789,GO:0006461,GO:0006621,GO:0015631,GO:0016020,GO:0016255,GO:0042765 endoplasmic reticulum membrane|protein complex assembly|protein retention in ER lumen|tubulin binding|membrane|attachment of GPI anchor to protein|GPI-anchor transamidase complex hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis GPALPP1 480.533507130605 509.866001780957 451.201012480253 0.884940378264509 -0.176347836165926 0.330300786447889 1 3.52895 3.37242 3.27295 2.8125 GeneID:55425,Genbank:NM_001316952.1,HGNC:HGNC:20298 GPALPP motifs containing 1 GPAM 304.933102199496 318.578526886734 291.287677512258 0.914335565421902 -0.129204356603674 0.536320789699795 1 1.73379 1.56839 1.68012 1.33078 GeneID:57678,Genbank:NM_020918.5,HGNC:HGNC:24865,MIM:602395 glycerol-3-phosphate acyltransferase, mitochondrial GO:0004366,GO:0005741,GO:0005743,GO:0005886,GO:0006631,GO:0006637,GO:0006654,GO:0009749,GO:0016021,GO:0016024,GO:0019432,GO:0033146,GO:0040018,GO:0042104,GO:0045540,GO:0050707,GO:0051607,GO:0055089,GO:0055091,GO:0070236,GO:0070970,GO:0102420 glycerol-3-phosphate O-acyltransferase activity|mitochondrial outer membrane|mitochondrial inner membrane|plasma membrane|fatty acid metabolic process|acyl-CoA metabolic process|phosphatidic acid biosynthetic process|response to glucose|integral component of membrane|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|regulation of intracellular estrogen receptor signaling pathway|positive regulation of multicellular organism growth|positive regulation of activated T cell proliferation|regulation of cholesterol biosynthetic process|regulation of cytokine secretion|defense response to virus|fatty acid homeostasis|phospholipid homeostasis|negative regulation of activation-induced cell death of T cells|interleukin-2 secretion|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity hsa00561,hsa00564 Glycerolipid metabolism|Glycerophospholipid metabolism GPANK1 662.470352363382 658.125279854011 666.815424872752 1.01320439327398 0.0189252377304072 0.923906108518542 1 6.41814 6.28521 6.39323 6.78592 GeneID:7918,Genbank:NM_001199237.1,HGNC:HGNC:13920,MIM:142610 G-patch domain and ankyrin repeats 1 GO:0003676 nucleic acid binding GPAT2 1.94560292927048 1.47021420587209 2.42099165266886 1.64669314376051 0.719571738294192 0.905411029604633 1 0 0 0 0 GeneID:150763,Genbank:NM_001321531.1,HGNC:HGNC:27168,MIM:616431 glycerol-3-phosphate acyltransferase 2, mitochondrial GO:0004366,GO:0005739,GO:0005741,GO:0006072,GO:0006654,GO:0016021,GO:0016024,GO:0019432,GO:0102420,GO:1990511 glycerol-3-phosphate O-acyltransferase activity|mitochondrion|mitochondrial outer membrane|glycerol-3-phosphate metabolic process|phosphatidic acid biosynthetic process|integral component of membrane|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity|piRNA biosynthetic process hsa00561,hsa00564 Glycerolipid metabolism|Glycerophospholipid metabolism GPAT3 446.387969221759 496.298907006168 396.477031437349 0.798867428157406 -0.323971986738903 0.0692673889442067 0.918407228165493 3.59137 3.85295 3.55176 2.45572 GeneID:84803,Genbank:XM_017008780.1,HGNC:HGNC:28157,MIM:610958 glycerol-3-phosphate acyltransferase 3 GO:0003841,GO:0004366,GO:0005783,GO:0005789,GO:0006654,GO:0016021,GO:0016024,GO:0019432,GO:0032006,GO:0102420 1-acylglycerol-3-phosphate O-acyltransferase activity|glycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|phosphatidic acid biosynthetic process|integral component of membrane|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|regulation of TOR signaling|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity hsa00561,hsa00564 Glycerolipid metabolism|Glycerophospholipid metabolism GPAT4 4159.3471245079 4130.07504684573 4188.61920217007 1.0141750826947 0.0203067343245277 0.894993764828284 1 24.5885 26.5248 26.9565 25.9576 GeneID:137964,Genbank:NM_178819.3,HGNC:HGNC:20880,MIM:608143 glycerol-3-phosphate acyltransferase 4 GO:0002071,GO:0003841,GO:0004366,GO:0005783,GO:0005789,GO:0006631,GO:0006637,GO:0006654,GO:0006656,GO:0007595,GO:0008610,GO:0016020,GO:0016021,GO:0016024,GO:0019432,GO:0040014,GO:0046339,GO:0102420 glandular epithelial cell maturation|1-acylglycerol-3-phosphate O-acyltransferase activity|glycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|acyl-CoA metabolic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|lactation|lipid biosynthetic process|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|triglyceride biosynthetic process|regulation of multicellular organism growth|diacylglycerol metabolic process|sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity hsa00561,hsa00564 Glycerolipid metabolism|Glycerophospholipid metabolism GPATCH1 401.571121792114 411.056926031766 392.085317552463 0.953846761171379 -0.0681705840607289 0.70397626135294 1 3.37091 3.80643 3.73838 3.04671 GeneID:55094,Genbank:NM_018025.2,HGNC:HGNC:24658 G-patch domain containing 1 GO:0000398,GO:0003676,GO:0071013 mRNA splicing, via spliceosome|nucleic acid binding|catalytic step 2 spliceosome GPATCH11 453.560552245557 497.614216732023 409.506887759091 0.822940490825286 -0.281139985862978 0.123958846105626 1 4.46541 3.95144 3.49961 3.48358 GeneID:253635,Genbank:NM_174931.3,HGNC:HGNC:26768 G-patch domain containing 11 GO:0000776,GO:0000777,GO:0003676 kinetochore|condensed chromosome kinetochore|nucleic acid binding GPATCH2 180.143328876437 181.447829235499 178.838828517375 0.985621207323799 -0.0208947964725341 0.952401873910946 1 0.701621 0.668724 0.740818 0.648647 GeneID:55105,Genbank:NM_018040.4,HGNC:HGNC:25499,MIM:616836 G-patch domain containing 2 GO:0003676,GO:0005730,GO:0010923,GO:0016607 nucleic acid binding|nucleolus|negative regulation of phosphatase activity|nuclear speck GPATCH2L 398.900471105117 377.578183219502 420.222758990732 1.11294237237865 0.154378892557717 0.441375219740045 1 0.503261 0.455506 0.651659 0.457652 GeneID:55668,Genbank:NM_017926.3,HGNC:HGNC:20210 G-patch domain containing 2 like GPATCH3 323.388556016354 286.706302450999 360.070809581709 1.25588731919574 0.328707028457188 0.101322781836789 1 4.22675 5.30177 6.08274 6.07636 GeneID:63906,Genbank:NM_022078.2,HGNC:HGNC:25720,MIM:617486 G-patch domain containing 3 GO:0003676,GO:0005634,GO:0005737,GO:0006351,GO:0032480,GO:0039536,GO:0045893 nucleic acid binding|nucleus|cytoplasm|transcription, DNA-templated|negative regulation of type I interferon production|negative regulation of RIG-I signaling pathway|positive regulation of transcription, DNA-templated GPATCH4 961.43533856389 1058.78382823934 864.08684888844 0.816112624543328 -0.293159835266317 0.0581967160496673 0.875517516166731 12.3644 11.7995 10.0491 9.52784 GeneID:54865,Genbank:NM_015590.3,HGNC:HGNC:25982 G-patch domain containing 4 GO:0003723 RNA binding GPATCH8 1570.04685671014 1646.83972326941 1493.25399015087 0.906739113133833 -0.141240576469717 0.329096943887772 1 3.60321 3.67445 3.72803 3.0088 GeneID:23131,Genbank:NM_001304939.1,HGNC:HGNC:29066,MIM:614396 G-patch domain containing 8 GO:0003723,GO:0046872 RNA binding|metal ion binding GPBAR1 1.6985006646334 0.490071401957362 2.90692992730943 5.93164570652165 2.56843242909583 0.446277189470547 1 0 0.0143536 0.0302828 0.0283471 GeneID:151306,Genbank:XM_017003468.1,HGNC:HGNC:19680,MIM:610147 G protein-coupled bile acid receptor 1 GO:0005737,GO:0005886,GO:0007186,GO:0016021,GO:0038181,GO:0038182,GO:0038184,GO:2000810 cytoplasm|plasma membrane|G-protein coupled receptor signaling pathway|integral component of membrane|bile acid receptor activity|G-protein coupled bile acid receptor activity|cell surface bile acid receptor signaling pathway|regulation of bicellular tight junction assembly GPBP1 708.620708590243 770.155457800088 647.085959380397 0.840201744760424 -0.251192313163626 0.391205562475294 1 5.55597 4.84408 5.31904 3.40166 GeneID:65056,Genbank:XM_024446172.1,HGNC:HGNC:29520,MIM:608412 GC-rich promoter binding protein 1 GO:0003677,GO:0003700,GO:0005634,GO:0005829,GO:0005886,GO:0006351,GO:0006355,GO:0043231,GO:0045893 DNA binding|DNA binding transcription factor activity|nucleus|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated GPBP1L1 1837.76392388274 1929.835142912 1745.69270485349 0.904581259837226 -0.144677986846352 0.316988584041907 1 18.0703 17.1293 17.1628 14.8624 GeneID:60313,Genbank:NM_021639.4,HGNC:HGNC:28843 GC-rich promoter binding protein 1 like 1 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0045893 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated GPC1 4502.30283800077 3942.37399324608 5062.23168275547 1.28405668549658 0.360708892553413 0.00769273725842906 0.342738246075193 43.2491 45.3069 56.7707 59.6483 GeneID:2817,Genbank:NM_002081.2,HGNC:HGNC:4449,MIM:600395 glypican 1 GO:0001523,GO:0005507,GO:0005576,GO:0005578,GO:0005615,GO:0005654,GO:0005768,GO:0005796,GO:0005829,GO:0005886,GO:0005887,GO:0006024,GO:0006027,GO:0007411,GO:0014037,GO:0017134,GO:0030200,GO:0030203,GO:0031012,GO:0031225,GO:0032288,GO:0040037,GO:0043202,GO:0043236,GO:0043395,GO:0045121,GO:0050900,GO:0070062,GO:2001016 retinoid metabolic process|copper ion binding|extracellular region|proteinaceous extracellular matrix|extracellular space|nucleoplasm|endosome|Golgi lumen|cytosol|plasma membrane|integral component of plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|axon guidance|Schwann cell differentiation|fibroblast growth factor binding|heparan sulfate proteoglycan catabolic process|glycosaminoglycan metabolic process|extracellular matrix|anchored component of membrane|myelin assembly|negative regulation of fibroblast growth factor receptor signaling pathway|lysosomal lumen|laminin binding|heparan sulfate proteoglycan binding|membrane raft|leukocyte migration|extracellular exosome|positive regulation of skeletal muscle cell differentiation hsa05205,hsa05418 Proteoglycans in cancer|Fluid shear stress and atherosclerosis GPC2 85.9671047349354 90.0368337894982 81.8973756803726 0.909598574643848 -0.136698101382645 0.691000572149151 1 1.70136 1.51554 1.3382 1.57447 GeneID:221914,Genbank:NM_152742.2,HGNC:HGNC:4450 glypican 2 GO:0001523,GO:0005578,GO:0005615,GO:0005783,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0007224,GO:0030182,GO:0030203,GO:0031225,GO:0043202,GO:0043395 retinoid metabolic process|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|smoothened signaling pathway|neuron differentiation|glycosaminoglycan metabolic process|anchored component of membrane|lysosomal lumen|heparan sulfate proteoglycan binding GPC3 20.1262768045267 21.3514192771683 18.9011343318851 0.885240184107885 -0.175859153353791 0.799260515763496 1 0.235293 0.336458 0.254545 0.277955 GeneID:2719,Genbank:NM_001164619.1,HGNC:HGNC:4451,MIM:300037 glypican 3 hsa05205 Proteoglycans in cancer GPC4 3992.94878493297 3856.66424782906 4129.23332203688 1.07067482588386 0.0985203864217383 0.457661923105138 1 39.5605 38.5719 46.0772 39.2702 GeneID:2239,Genbank:NM_001448.2,HGNC:HGNC:4452,MIM:300168 glypican 4 GO:0001523,GO:0005578,GO:0005634,GO:0005796,GO:0005886,GO:0005887,GO:0006024,GO:0006027,GO:0008283,GO:0009653,GO:0009897,GO:0030203,GO:0031225,GO:0043202,GO:0043395,GO:0070062,GO:1904929 retinoid metabolic process|proteinaceous extracellular matrix|nucleus|Golgi lumen|plasma membrane|integral component of plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cell proliferation|anatomical structure morphogenesis|external side of plasma membrane|glycosaminoglycan metabolic process|anchored component of membrane|lysosomal lumen|heparan sulfate proteoglycan binding|extracellular exosome|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway hsa04310 Wnt signaling pathway GPC5 5.74476988449805 5.18887166768327 6.30066810131283 1.21426554843395 0.280083959909043 0.881643515143183 1 0.0210768 0.0164665 0.0286429 0.0228138 GeneID:2262,Genbank:NM_004466.5,HGNC:HGNC:4453,MIM:602446 glypican 5 GPC6 563.396299032166 516.092851182348 610.699746881985 1.1833137108621 0.242832600394762 0.192795816844001 1 1.21871 1.17204 1.66704 1.24535 GeneID:10082,Genbank:NM_005708.4,HGNC:HGNC:4454,MIM:604404 glypican 6 GO:0001523,GO:0005578,GO:0005615,GO:0005634,GO:0005796,GO:0005886,GO:0005887,GO:0006024,GO:0006027,GO:0016477,GO:0030203,GO:0031225,GO:0043202,GO:0043395,GO:1904929 retinoid metabolic process|proteinaceous extracellular matrix|extracellular space|nucleus|Golgi lumen|plasma membrane|integral component of plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cell migration|glycosaminoglycan metabolic process|anchored component of membrane|lysosomal lumen|heparan sulfate proteoglycan binding|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway GPCPD1 156.514610992794 181.188080551858 131.84114143373 0.727647983422372 -0.458687412861435 0.155393005806148 1 1.2133 0.962381 0.960065 0.568241 GeneID:56261,Genbank:NM_019593.3,HGNC:HGNC:26957,MIM:614124 glycerophosphocholine phosphodiesterase 1 GO:0005829,GO:0007519,GO:0008889,GO:0030643,GO:0046475,GO:0047389,GO:2001070 cytosol|skeletal muscle tissue development|glycerophosphodiester phosphodiesterase activity|cellular phosphate ion homeostasis|glycerophospholipid catabolic process|glycerophosphocholine phosphodiesterase activity|starch binding hsa00564,hsa05231 Glycerophospholipid metabolism|Choline metabolism in cancer GPD1 2.51489177275894 3.57457863775636 1.45520490776151 0.407098305906872 -1.29655087700767 0.586912010107505 1 0.0448045 0.0532591 0.0420454 0 GeneID:2819,Genbank:NM_005276.3,HGNC:HGNC:4455,MIM:138420 glycerol-3-phosphate dehydrogenase 1 GO:0004367,GO:0004368,GO:0005739,GO:0005829,GO:0006094,GO:0006127,GO:0006654,GO:0009331,GO:0042803,GO:0045821,GO:0046168,GO:0051287,GO:0070062,GO:0071320,GO:0071356 glycerol-3-phosphate dehydrogenase [NAD+] activity|glycerol-3-phosphate dehydrogenase activity|mitochondrion|cytosol|gluconeogenesis|glycerophosphate shuttle|phosphatidic acid biosynthetic process|glycerol-3-phosphate dehydrogenase complex|protein homodimerization activity|positive regulation of glycolytic process|glycerol-3-phosphate catabolic process|NAD binding|extracellular exosome|cellular response to cAMP|cellular response to tumor necrosis factor hsa00564 Glycerophospholipid metabolism GPD1L 866.889314055589 908.939683101682 824.838945009495 0.907473796495274 -0.14007210931298 0.385353594270755 1 9.95379 9.20758 8.94425 8.64157 GeneID:23171,Genbank:NM_015141.3,HGNC:HGNC:28956,MIM:611778 glycerol-3-phosphate dehydrogenase 1 like GO:0002027,GO:0004367,GO:0005829,GO:0005886,GO:0005975,GO:0006654,GO:0006734,GO:0009331,GO:0010765,GO:0017080,GO:0019674,GO:0033137,GO:0042803,GO:0044325,GO:0046168,GO:0051287,GO:0060373,GO:0070062,GO:0086005,GO:0090038,GO:2000010,GO:2000649 regulation of heart rate|glycerol-3-phosphate dehydrogenase [NAD+] activity|cytosol|plasma membrane|carbohydrate metabolic process|phosphatidic acid biosynthetic process|NADH metabolic process|glycerol-3-phosphate dehydrogenase complex|positive regulation of sodium ion transport|sodium channel regulator activity|NAD metabolic process|negative regulation of peptidyl-serine phosphorylation|protein homodimerization activity|ion channel binding|glycerol-3-phosphate catabolic process|NAD binding|regulation of ventricular cardiac muscle cell membrane depolarization|extracellular exosome|ventricular cardiac muscle cell action potential|negative regulation of protein kinase C signaling|positive regulation of protein localization to cell surface|regulation of sodium ion transmembrane transporter activity hsa00564 Glycerophospholipid metabolism GPD2 1258.75354699874 1350.40741101756 1167.09968297992 0.864257462938891 -0.21046693854786 0.326217599870966 1 8.88538 7.71429 8.22835 6.24325 GeneID:2820,Genbank:XM_011510977.2,HGNC:HGNC:4456,MIM:138430 glycerol-3-phosphate dehydrogenase 2 GO:0004368,GO:0005509,GO:0005743,GO:0006094,GO:0006127,GO:0009331,GO:0019563,GO:0035264,GO:0043010,GO:0052591 glycerol-3-phosphate dehydrogenase activity|calcium ion binding|mitochondrial inner membrane|gluconeogenesis|glycerophosphate shuttle|glycerol-3-phosphate dehydrogenase complex|glycerol catabolic process|multicellular organism growth|camera-type eye development|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity hsa00564 Glycerophospholipid metabolism GPER1 322.865068058844 296.795888138256 348.934247979433 1.17567076204536 0.233484100593539 0.251849947662812 1 3.97141 4.84851 5.3847 5.37378 GeneID:2852,Genbank:NM_001039966.1,HGNC:HGNC:4485,MIM:601805 G protein-coupled estrogen receptor 1 hsa01522,hsa04915 Endocrine resistance|Estrogen signaling pathway GPHN 216.487058932805 220.230096574176 212.744021291433 0.966007937156664 -0.049893051944829 0.836292140363903 1 1.32314 1.33692 1.27268 1.25838 GeneID:10243,Genbank:NM_020806.4,HGNC:HGNC:15465,MIM:603930 gephyrin GO:0005102,GO:0005524,GO:0005622,GO:0005737,GO:0005856,GO:0006605,GO:0006777,GO:0007416,GO:0007529,GO:0008940,GO:0010038,GO:0015631,GO:0018315,GO:0030054,GO:0030425,GO:0030674,GO:0031234,GO:0032324,GO:0032947,GO:0042803,GO:0043025,GO:0043546,GO:0045184,GO:0045202,GO:0045211,GO:0046872,GO:0051260,GO:0060077,GO:0061598,GO:0061599,GO:0072579,GO:0097112,GO:0098794,GO:0098970,GO:0099572,GO:0099634 receptor binding|ATP binding|intracellular|cytoplasm|cytoskeleton|protein targeting|Mo-molybdopterin cofactor biosynthetic process|synapse assembly|establishment of synaptic specificity at neuromuscular junction|nitrate reductase activity|response to metal ion|tubulin binding|molybdenum incorporation into molybdenum-molybdopterin complex|cell junction|dendrite|protein binding, bridging|extrinsic component of cytoplasmic side of plasma membrane|molybdopterin cofactor biosynthetic process|protein complex scaffold activity|protein homodimerization activity|neuronal cell body|molybdopterin cofactor binding|establishment of protein localization|synapse|postsynaptic membrane|metal ion binding|protein homooligomerization|inhibitory synapse|molybdopterin adenylyltransferase activity|molybdopterin molybdotransferase activity|glycine receptor clustering|gamma-aminobutyric acid receptor clustering|postsynapse|postsynaptic neurotransmitter receptor diffusion trapping|postsynaptic specialization|postsynaptic specialization membrane hsa00790,hsa04727 Folate biosynthesis|GABAergic synapse GPI 15699.3930574792 15372.5986619778 16026.1874529806 1.04251648048416 0.0600701905043122 0.65045526339656 1 55.2569 57.2376 57.1107 61.7622 GeneID:2821,Genbank:XM_011526754.3,HGNC:HGNC:4458,MIM:172400 glucose-6-phosphate isomerase hsa00010,hsa00030,hsa00500,hsa00520 Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism GPKOW 642.769409267572 620.159459184978 665.379359350166 1.07291656927174 0.101537895500186 0.541156960777799 1 10.4164 10.1398 11.3731 10.711 GeneID:27238,Genbank:NM_015698.5,HGNC:HGNC:30677,MIM:301003 G-patch domain and KOW motifs GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005681 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|spliceosomal complex GPLD1 86.3431321267898 107.755839499117 64.9304247544624 0.602569893717865 -0.730799501724272 0.0226888737664039 0.612664613324667 0.542257 0.454547 0.263034 0.339317 GeneID:2822,Genbank:XM_017010753.2,HGNC:HGNC:4459,MIM:602515 glycosylphosphatidylinositol specific phospholipase D1 GO:0001503,GO:0002042,GO:0002062,GO:0002430,GO:0004621,GO:0004630,GO:0005576,GO:0005578,GO:0005615,GO:0005622,GO:0005737,GO:0005765,GO:0006501,GO:0006507,GO:0008285,GO:0008286,GO:0009749,GO:0010595,GO:0010694,GO:0010867,GO:0010897,GO:0010907,GO:0010983,GO:0017080,GO:0032869,GO:0035690,GO:0035701,GO:0035774,GO:0043065,GO:0043231,GO:0045919,GO:0046470,GO:0051044,GO:0051047,GO:0070062,GO:0070633,GO:0071277,GO:0071397,GO:0071401,GO:0071467,GO:0097241,GO:1900076 ossification|cell migration involved in sprouting angiogenesis|chondrocyte differentiation|complement receptor mediated signaling pathway|glycosylphosphatidylinositol phospholipase D activity|phospholipase D activity|extracellular region|proteinaceous extracellular matrix|extracellular space|intracellular|cytoplasm|lysosomal membrane|C-terminal protein lipidation|GPI anchor release|negative regulation of cell proliferation|insulin receptor signaling pathway|response to glucose|positive regulation of endothelial cell migration|positive regulation of alkaline phosphatase activity|positive regulation of triglyceride biosynthetic process|negative regulation of triglyceride catabolic process|positive regulation of glucose metabolic process|positive regulation of high-density lipoprotein particle clearance|sodium channel regulator activity|cellular response to insulin stimulus|cellular response to drug|hematopoietic stem cell migration|positive regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of cytolysis|phosphatidylcholine metabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of secretion|extracellular exosome|transepithelial transport|cellular response to calcium ion|cellular response to cholesterol|cellular response to triglyceride|cellular response to pH|hematopoietic stem cell migration to bone marrow|regulation of cellular response to insulin stimulus hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis GPM6A 3985.65613612923 4006.44750703436 3964.8647652241 0.989621044145157 -0.0150519155501899 0.934404700995302 1 37.1351 35.2772 37.6437 33.3869 GeneID:2823,Genbank:NM_001261447.1,HGNC:HGNC:4460,MIM:601275 glycoprotein M6A GO:0001764,GO:0003407,GO:0005262,GO:0005886,GO:0007416,GO:0016021,GO:0030175,GO:0043005,GO:0043025,GO:0043197,GO:0044295,GO:0048812,GO:0048863,GO:0051491,GO:0070062,GO:1903561 neuron migration|neural retina development|calcium channel activity|plasma membrane|synapse assembly|integral component of membrane|filopodium|neuron projection|neuronal cell body|dendritic spine|axonal growth cone|neuron projection morphogenesis|stem cell differentiation|positive regulation of filopodium assembly|extracellular exosome|extracellular vesicle GPM6B 780.011251948703 752.590339569632 807.432164327774 1.07287075301751 0.101476287453482 0.500867530234138 1 6.47194 5.60415 6.94061 5.81421 GeneID:2824,Genbank:NM_001318729.1,HGNC:HGNC:4461,MIM:300051 glycoprotein M6B GO:0001503,GO:0005886,GO:0007399,GO:0015031,GO:0016021,GO:0030154,GO:0030501,GO:0032956,GO:0045121,GO:0051612,GO:0051893,GO:0085029,GO:2000009 ossification|plasma membrane|nervous system development|protein transport|integral component of membrane|cell differentiation|positive regulation of bone mineralization|regulation of actin cytoskeleton organization|membrane raft|negative regulation of serotonin uptake|regulation of focal adhesion assembly|extracellular matrix assembly|negative regulation of protein localization to cell surface GPN1 1445.96600160869 1503.9830732747 1387.94892994268 0.922848770445683 -0.115833845720292 0.4162610298806 1 21.4177 24.1293 21.2043 20.9815 GeneID:11321,Genbank:NM_001145047.1,HGNC:HGNC:17030,MIM:611479 GPN-loop GTPase 1 GO:0003924,GO:0005525,GO:0005654,GO:0005739,GO:0005829,GO:0044376,GO:1990022 GTPase activity|GTP binding|nucleoplasm|mitochondrion|cytosol|RNA polymerase II complex import to nucleus|RNA polymerase III complex localization to nucleus GPN2 727.971520620576 743.540765617792 712.402275623359 0.958121341244066 -0.061719717291806 0.683933793188687 1 19.8776 22.744 21.6185 20.9977 GeneID:54707,Genbank:NM_018066.3,HGNC:HGNC:25513 GPN-loop GTPase 2 GO:0003924,GO:0005525,GO:0005737,GO:0044376,GO:1990022 GTPase activity|GTP binding|cytoplasm|RNA polymerase II complex import to nucleus|RNA polymerase III complex localization to nucleus GPN3 401.906854849537 474.783791594729 329.029918104344 0.693010005668435 -0.529051912764377 0.00415492608369096 0.253023939758154 9.45331 9.19315 6.12521 7.1457 GeneID:51184,Genbank:NM_001164372.1,HGNC:HGNC:30186 GPN-loop GTPase 3 GO:0003924,GO:0005525,GO:0005622,GO:0043234,GO:0044376,GO:1990022 GTPase activity|GTP binding|intracellular|protein complex|RNA polymerase II complex import to nucleus|RNA polymerase III complex localization to nucleus GPNMB 5656.62696495834 4720.10779379128 6593.14613612541 1.3968210948059 0.482147251839197 0.000275441824504861 0.0445603662754531 45.515 47.4464 64.3742 66.0186 GeneID:10457,Genbank:NM_001005340.1,HGNC:HGNC:4462,MIM:604368 glycoprotein nmb GPR1 126.779604447702 105.277073524861 148.282135370543 1.40849408523429 0.494153505337928 0.0709685481015047 0.924091273490813 1.42442 1.6995 2.06255 2.46459 GeneID:2825,Genbank:NM_001098199.1,HGNC:HGNC:4463,MIM:600239 G protein-coupled receptor 1 GO:0004930,GO:0005654,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007218,GO:0007268,GO:0042923,GO:0043005,GO:0043231 G-protein coupled receptor activity|nucleoplasm|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|neuropeptide signaling pathway|chemical synaptic transmission|neuropeptide binding|neuron projection|intracellular membrane-bounded organelle GPR107 2704.68947436391 2518.59384875384 2890.78509997398 1.14777740023637 0.198842873098661 0.148213452140192 1 11.6368 11.8651 13.8715 13.5343 GeneID:57720,Genbank:NM_001136557.1,HGNC:HGNC:17830 G protein-coupled receptor 107 GO:0005654,GO:0005769,GO:0005794,GO:0016021,GO:0030136,GO:0032050,GO:0072583 nucleoplasm|early endosome|Golgi apparatus|integral component of membrane|clathrin-coated vesicle|clathrin heavy chain binding|clathrin-dependent endocytosis GPR108 1428.83548005715 1389.80929627631 1467.86166383798 1.05616048746457 0.0788290741633299 0.642984117406326 1 14.1657 16.2143 15.7454 16.9868 GeneID:56927,Genbank:NM_001080452.1,HGNC:HGNC:17829 G protein-coupled receptor 108 GO:0016021 integral component of membrane GPR12 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00929266 GeneID:2835,Genbank:XM_005266360.3,HGNC:HGNC:4466,MIM:600752 G protein-coupled receptor 12 GO:0004930,GO:0005887,GO:0006874,GO:0007186,GO:0031210 G-protein coupled receptor activity|integral component of plasma membrane|cellular calcium ion homeostasis|G-protein coupled receptor signaling pathway|phosphatidylcholine binding GPR132 1.21930543346982 1.47021420587209 0.968396661067546 0.658677257504203 -0.60235635659317 0.974344551264944 1 0 0.0212287 0 0 GeneID:29933,Genbank:NM_001278696.1,HGNC:HGNC:17482,MIM:606167 G protein-coupled receptor 132 GO:0000082,GO:0004930,GO:0005886,GO:0007186,GO:0010972,GO:0016021 G1/S transition of mitotic cell cycle|G-protein coupled receptor activity|plasma membrane|G-protein coupled receptor signaling pathway|negative regulation of G2/M transition of mitotic cell cycle|integral component of membrane GPR135 64.2006848386259 68.7814670616998 59.6199026155521 0.866801845940136 -0.206225869090935 0.619994009508159 1 0.371359 0.277137 0.350655 0.216274 GeneID:64582,Genbank:XM_017021599.2,HGNC:HGNC:19991,MIM:607970 G protein-coupled receptor 135 GO:0004930,GO:0005886,GO:0016021 G-protein coupled receptor activity|plasma membrane|integral component of membrane GPR137 1121.20336257028 1067.63555644075 1174.77116869981 1.10034848653432 0.137960505725441 0.37338602942745 1 10.9789 11.2174 13.7994 11.5356 GeneID:56834,Genbank:XM_011545170.2,HGNC:HGNC:24300 G protein-coupled receptor 137 GO:0016021 integral component of membrane GPR137B 419.560815165961 433.003260914514 406.118369417408 0.937910648893672 -0.0924776055561014 0.630509545670568 1 2.1575 2.02386 2.0489 1.84524 GeneID:7107,Genbank:XM_017002209.2,HGNC:HGNC:11862,MIM:604658 G protein-coupled receptor 137B GO:0005765,GO:0005887,GO:0016020 lysosomal membrane|integral component of plasma membrane|membrane GPR137C 84.5354034989367 96.8399984871084 72.2308085107651 0.745877836009886 -0.4229887376175 0.330479610720412 1 0.958759 0.940262 0.985028 0.453358 GeneID:283554,Genbank:XM_024449541.1,HGNC:HGNC:25445 G protein-coupled receptor 137C GO:0016021 integral component of membrane GPR141 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00354882 GeneID:353345,Genbank:XM_011515374.3,HGNC:HGNC:19997,MIM:609045 G protein-coupled receptor 141 GO:0004930,GO:0005886,GO:0016021 G-protein coupled receptor activity|plasma membrane|integral component of membrane GPR143 2.95313039226616 3.96859749034384 1.93766329418849 0.488248883617726 -1.03431134949729 0.61456569720008 1 0 0.126703 0 0.0493562 GeneID:4935,Genbank:XM_024452387.1,HGNC:HGNC:20145,MIM:300808 G protein-coupled receptor 143 GPR146 55.3417139502497 47.6897964681721 62.9936314323273 1.32090375924269 0.401525355970564 0.30473317599578 1 0.894959 0.871327 1.04676 1.31194 GeneID:115330,Genbank:NM_001303473.1,HGNC:HGNC:21718 G protein-coupled receptor 146 GO:0004930,GO:0005886,GO:0016021 G-protein coupled receptor activity|plasma membrane|integral component of membrane GPR15 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0182549 0 0 GeneID:2838,Genbank:NM_005290.3,HGNC:HGNC:4469,MIM:601166 G protein-coupled receptor 15 GO:0001618,GO:0004930,GO:0005768,GO:0005886,GO:0005887,GO:0007186,GO:0015026,GO:0046718,GO:0072678 virus receptor activity|G-protein coupled receptor activity|endosome|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|coreceptor activity|viral entry into host cell|T cell migration GPR153 289.952480565699 238.228468277652 341.676492853746 1.43423871766462 0.520285169178085 0.0112994005256591 0.430883806711799 2.24087 2.76845 3.91006 3.39673 GeneID:387509,Genbank:NM_207370.3,HGNC:HGNC:23618,MIM:614269 G protein-coupled receptor 153 GO:0004930,GO:0005886,GO:0016021 G-protein coupled receptor activity|plasma membrane|integral component of membrane GPR155 71.1448543341785 66.6869112849235 75.6027973834335 1.13369769159673 0.181035986859697 0.612964416823187 1 0.329453 0.350122 0.383501 0.37774 GeneID:151556,Genbank:NM_001267051.1,HGNC:HGNC:22951 G protein-coupled receptor 155 GO:0005737,GO:0016021,GO:0035556,GO:0050890,GO:0055085,GO:0070062 cytoplasm|integral component of membrane|intracellular signal transduction|cognition|transmembrane transport|extracellular exosome GPR156 36.2670985100171 32.3152865638621 40.218910456172 1.24457848692416 0.315657213947541 0.518375766734359 1 0.168141 0.167725 0.172468 0.24185 GeneID:165829,Genbank:XM_017005797.2,HGNC:HGNC:20844,MIM:610464 G protein-coupled receptor 156 GO:0004965,GO:0005886,GO:0016021 G-protein coupled GABA receptor activity|plasma membrane|integral component of membrane hsa04080 Neuroactive ligand-receptor interaction GPR157 65.0541383936116 69.5312871472978 60.5769896399254 0.871219160830387 -0.198892411113769 0.582896419094508 1 1.47422 1.62157 1.36057 1.26919 GeneID:80045,Genbank:XM_005263497.5,HGNC:HGNC:23687 G protein-coupled receptor 157 GO:0004930,GO:0007166,GO:0007186,GO:0016021,GO:0048512,GO:0051482,GO:0060019,GO:0060170 G-protein coupled receptor activity|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|integral component of membrane|circadian behavior|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|radial glial cell differentiation|ciliary membrane GPR158 28.307979456499 20.2654152687757 36.3505436442222 1.79372310718103 0.842957202003009 0.109138386263097 1 0.122253 0.0575795 0.191144 0.163331 GeneID:57512,Genbank:NM_020752.2,HGNC:HGNC:23689,MIM:614573 G protein-coupled receptor 158 GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0072659 G-protein coupled receptor activity|plasma membrane|G-protein coupled receptor signaling pathway|integral component of membrane|protein localization to plasma membrane GPR160 174.512848587634 172.146281253417 176.879415921851 1.02749484121279 0.0391311505245615 0.87347954803296 1 2.06503 1.84899 1.77155 1.98415 GeneID:26996,Genbank:NM_014373.2,HGNC:HGNC:23693 G protein-coupled receptor 160 GO:0004930,GO:0005886,GO:0016021,GO:0043235 G-protein coupled receptor activity|plasma membrane|integral component of membrane|receptor complex GPR161 879.91488877878 858.368310152413 901.461467405147 1.05020357432007 0.0706690109340654 0.655739621217978 1 3.31118 3.48062 3.89227 3.28391 GeneID:23432,Genbank:NM_001349635.1,HGNC:HGNC:23694,MIM:612250 G protein-coupled receptor 161 GO:0004930,GO:0005929,GO:0007186,GO:0007275,GO:0016021,GO:0030666,GO:0030819,GO:0055037,GO:0060170,GO:1901621 G-protein coupled receptor activity|cilium|G-protein coupled receptor signaling pathway|multicellular organism development|integral component of membrane|endocytic vesicle membrane|positive regulation of cAMP biosynthetic process|recycling endosome|ciliary membrane|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning hsa04340 Hedgehog signaling pathway GPR162 155.488468593062 133.62376259838 177.353174587744 1.32725775071009 0.408448566308778 0.104940614038992 1 2.43101 2.57048 2.93515 3.47901 GeneID:27239,Genbank:NM_019858.1,HGNC:HGNC:16693 G protein-coupled receptor 162 GO:0004930,GO:0005886,GO:0016021 G-protein coupled receptor activity|plasma membrane|integral component of membrane GPR17 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:2840,Genbank:NM_001161415.1,HGNC:HGNC:4471,MIM:603071 G protein-coupled receptor 17 GO:0002376,GO:0002862,GO:0004950,GO:0005886,GO:0005887,GO:0007186,GO:0035025,GO:0051482 immune system process|negative regulation of inflammatory response to antigenic stimulus|chemokine receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|positive regulation of Rho protein signal transduction|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GPR173 134.616532989027 134.498044197817 134.735021780238 1.00176194073182 0.00253970640650047 1 1 1.0581 1.06391 1.2579 0.990362 GeneID:54328,Genbank:NM_018969.5,HGNC:HGNC:18186,MIM:300253 G protein-coupled receptor 173 GO:0004930,GO:0004968,GO:0005886,GO:0007165,GO:0016021,GO:2001223 G-protein coupled receptor activity|gonadotropin-releasing hormone receptor activity|plasma membrane|signal transduction|integral component of membrane|negative regulation of neuron migration GPR176 1692.81400083977 1638.9329712549 1746.69503042464 1.06575135228821 0.091870885879612 0.534139276112908 1 6.27438 6.85117 7.59554 6.50323 GeneID:11245,Genbank:XM_017021878.2,HGNC:HGNC:32370,MIM:612183 G protein-coupled receptor 176 GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0007193,GO:0007268,GO:0030818,GO:0048512 G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|chemical synaptic transmission|negative regulation of cAMP biosynthetic process|circadian behavior GPR179 1.2378804854154 0.538097676642304 1.93766329418849 3.60095086505369 1.84837791409998 0.680650629779701 1 0 0 0.00393092 0.0110182 GeneID:440435,Genbank:NM_001004334.3,HGNC:HGNC:31371,MIM:614515 G protein-coupled receptor 179 GPR180 311.612410295156 369.727232133077 253.497588457236 0.685634074057044 -0.544489285828457 0.0423803923822621 0.766965383496396 2.15446 1.80063 1.64734 1.13708 GeneID:160897,Genbank:NM_180989.5,HGNC:HGNC:28899,MIM:607787 G protein-coupled receptor 180 GO:0007186,GO:0016021,GO:0019236,GO:0070062 G-protein coupled receptor signaling pathway|integral component of membrane|response to pheromone|extracellular exosome GPR19 35.8915688437538 34.4676772704313 37.3154604170762 1.08262184667395 0.114529406198782 0.830026599681589 1 0.148256 0.156889 0.179425 0.143425 GeneID:2842,Genbank:XM_017019216.2,HGNC:HGNC:4473,MIM:602927 G protein-coupled receptor 19 GO:0004930,GO:0005887,GO:0007186,GO:0007218,GO:0007268,GO:0007631 G-protein coupled receptor activity|integral component of plasma membrane|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|feeding behavior GPR3 148.597406193988 118.355113898547 178.839698489428 1.51104327137674 0.59554497519948 0.0209717685139782 0.592744489333324 2.50428 3.18302 4.83888 3.95972 GeneID:2827,Genbank:NM_005281.3,HGNC:HGNC:4484,MIM:600241 G protein-coupled receptor 3 GO:0004930,GO:0005622,GO:0005887,GO:0007189,GO:0040020 G-protein coupled receptor activity|intracellular|integral component of plasma membrane|adenylate cyclase-activating G-protein coupled receptor signaling pathway|regulation of meiotic nuclear division GPR35 1.72294878800257 0.538097676642304 2.90779989936283 5.40385142992498 2.43398801066343 0.443399387359121 1 0.0219973 0 0.0405592 0.037915 GeneID:2859,Genbank:NM_001195381.1,HGNC:HGNC:4492,MIM:602646 G protein-coupled receptor 35 GO:0004930,GO:0005886,GO:0005887,GO:0007010,GO:0007186,GO:0007204,GO:0016494,GO:0035025,GO:0051482,GO:0070098,GO:1901386,GO:1904456 G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|cytoskeleton organization|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|C-X-C chemokine receptor activity|positive regulation of Rho protein signal transduction|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|chemokine-mediated signaling pathway|negative regulation of voltage-gated calcium channel activity|negative regulation of neuronal action potential hsa04080 Neuroactive ligand-receptor interaction GPR37 150.836603336638 119.421500596724 182.251706076553 1.52612138656674 0.609869717633169 0.0595430357928959 0.879410748501007 0.979056 1.03701 1.88016 1.23786 GeneID:2861,Genbank:NM_005302.4,HGNC:HGNC:4494,MIM:602583 G protein-coupled receptor 37 GO:0000151,GO:0004930,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0007186,GO:0007193,GO:0008528,GO:0030544,GO:0031072,GO:0031625,GO:0031987,GO:0036505,GO:0042277,GO:0042416,GO:0043235,GO:0043410,GO:0045964,GO:1903206 ubiquitin ligase complex|G-protein coupled receptor activity|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|G-protein coupled peptide receptor activity|Hsp70 protein binding|heat shock protein binding|ubiquitin protein ligase binding|locomotion involved in locomotory behavior|prosaposin receptor activity|peptide binding|dopamine biosynthetic process|receptor complex|positive regulation of MAPK cascade|positive regulation of dopamine metabolic process|negative regulation of hydrogen peroxide-induced cell death hsa05012 Parkinson disease GPR37L1 6.7017695231237 7.10113100082778 6.30240804541962 0.887521726424277 -0.172145657950679 0.936969048644504 1 0.0364889 0.0512249 0.060536 0.025199 GeneID:9283,Genbank:XM_011510158.2,HGNC:HGNC:14923,MIM:617630 G protein-coupled receptor 37 like 1 GO:0005886,GO:0007186,GO:0007193,GO:0008528,GO:0016021,GO:0021940,GO:0036505,GO:0042277,GO:0043235,GO:0043410,GO:0045665,GO:0045879,GO:0048712,GO:1903206 plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|G-protein coupled peptide receptor activity|integral component of membrane|positive regulation of cerebellar granule cell precursor proliferation|prosaposin receptor activity|peptide binding|receptor complex|positive regulation of MAPK cascade|negative regulation of neuron differentiation|negative regulation of smoothened signaling pathway|negative regulation of astrocyte differentiation|negative regulation of hydrogen peroxide-induced cell death GPR39 955.841895820015 962.838745662739 948.845045977291 0.985466206310782 -0.0211216957888459 0.878516930101059 1 10.5822 10.8554 10.2198 10.9424 GeneID:2863,Genbank:XM_011511021.2,HGNC:HGNC:4496,MIM:602886 G protein-coupled receptor 39 GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0046872 G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|metal ion binding GPR55 2.20877869616804 1.02816907859967 3.38938831373641 3.29652815308611 1.72094740234999 0.613833916777325 1 0.0081291 0.00734687 0 0.0500748 GeneID:9290,Genbank:XM_011512175.3,HGNC:HGNC:4511,MIM:604107 G protein-coupled receptor 55 GO:0004930,GO:0004949,GO:0005886,GO:0005887,GO:0007186,GO:0007202,GO:0035025,GO:0045453,GO:0045671,GO:0051482,GO:0070374 G-protein coupled receptor activity|cannabinoid receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of Rho protein signal transduction|bone resorption|negative regulation of osteoclast differentiation|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|positive regulation of ERK1 and ERK2 cascade GPR61 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0156862 0 GeneID:83873,Genbank:NM_031936.4,HGNC:HGNC:13300,MIM:606916 G protein-coupled receptor 61 GO:0004930,GO:0005886,GO:0016021,GO:0043235 G-protein coupled receptor activity|plasma membrane|integral component of membrane|receptor complex GPR62 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0.0268328 0 GeneID:118442,Genbank:NM_080865.3,HGNC:HGNC:13301,MIM:606917 G protein-coupled receptor 62 GO:0004930,GO:0005886,GO:0016021,GO:0043235 G-protein coupled receptor activity|plasma membrane|integral component of membrane|receptor complex GPR63 77.2655786511044 98.3102126929805 56.2209446092283 0.571872881455403 -0.806233601161913 0.0161832968557913 0.529251203244782 0.663422 0.529505 0.411898 0.34391 GeneID:81491,Genbank:NM_030784.3,HGNC:HGNC:13302,MIM:606915 G protein-coupled receptor 63 GO:0004930,GO:0005634,GO:0005829,GO:0005886,GO:0016021,GO:0043235 G-protein coupled receptor activity|nucleus|cytosol|plasma membrane|integral component of membrane|receptor complex GPR68 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00747026 0 0 0 GeneID:8111,Genbank:XM_005268112.3,HGNC:HGNC:4519,MIM:601404 G protein-coupled receptor 68 GPR75 11.2339770176289 11.7999312665537 10.6680227687042 0.904074992279161 -0.145485646912885 0.926304116095866 1 0.240679 0.218059 0.288563 0.0577362 GeneID:10936,Genbank:NM_006794.3,HGNC:HGNC:4526,MIM:606704 G protein-coupled receptor 75 GO:0004930,GO:0005887,GO:0007186,GO:0016493,GO:0070098,GO:1901214 G-protein coupled receptor activity|integral component of plasma membrane|G-protein coupled receptor signaling pathway|C-C chemokine receptor activity|chemokine-mediated signaling pathway|regulation of neuron death GPR83 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.0100624 0 0.0190682 0 GeneID:10888,Genbank:NM_001330345.1,HGNC:HGNC:4523,MIM:605569 G protein-coupled receptor 83 GO:0004930,GO:0004983,GO:0005886,GO:0007186,GO:0016021,GO:0051384,GO:0097730 G-protein coupled receptor activity|neuropeptide Y receptor activity|plasma membrane|G-protein coupled receptor signaling pathway|integral component of membrane|response to glucocorticoid|non-motile cilium hsa04080 Neuroactive ligand-receptor interaction GPR85 40.0686715546494 41.8569659193687 38.2803771899302 0.914552126488854 -0.128862693657192 0.81902673380189 1 0.377658 0.266767 0.275337 0.38018 GeneID:54329,Genbank:NM_018970.6,HGNC:HGNC:4536,MIM:605188 G protein-coupled receptor 85 GO:0004930,GO:0005783,GO:0005886,GO:0016021 G-protein coupled receptor activity|endoplasmic reticulum|plasma membrane|integral component of membrane GPR87 7.00396772547431 9.64754055998448 4.36039489096415 0.451969583735149 -1.14570240824463 0.316030951283079 1 0.207432 0.334704 0.028284 0.157742 GeneID:53836,Genbank:NM_023915.3,HGNC:HGNC:4538,MIM:606379 G protein-coupled receptor 87 GO:0005887,GO:0007194,GO:0045028 integral component of plasma membrane|negative regulation of adenylate cyclase activity|G-protein coupled purinergic nucleotide receptor activity GPR89A 239.048471466647 230.846954282113 247.24998865118 1.07105588384338 0.0990337566898049 0.872910959274626 1 2.32886 1.70449 3.41883 1.54493 GeneID:653519,Genbank:NM_001097613.2,HGNC:HGNC:31984,MIM:612821 G protein-coupled receptor 89A GO:0008308,GO:0015031,GO:0016021,GO:0032580,GO:0034765,GO:0051452 voltage-gated anion channel activity|protein transport|integral component of membrane|Golgi cisterna membrane|regulation of ion transmembrane transport|intracellular pH reduction GPR89B 87.7196725401809 104.681140918426 70.7582041619356 0.675940322594255 -0.565032215388548 0.0730968353438098 0.934332733333167 1.19132 1.1903 0.940744 0.702342 GeneID:51463,Genbank:NM_001350184.1,HGNC:HGNC:13840,MIM:612806 G protein-coupled receptor 89B GO:0008308,GO:0015031,GO:0016021,GO:0032580,GO:0034765,GO:0051452 voltage-gated anion channel activity|protein transport|integral component of membrane|Golgi cisterna membrane|regulation of ion transmembrane transport|intracellular pH reduction GPRASP1 9.09332285924801 10.9158410120089 7.27080470648717 0.666078289202667 -0.586236336800433 0.590078459715861 1 0.0709185 0.0417017 0.0475155 0.0294211 GeneID:9737,Genbank:NM_014710.4,HGNC:HGNC:24834,MIM:300417 G protein-coupled receptor associated sorting protein 1 GO:0005829,GO:0008333,GO:1990172 cytosol|endosome to lysosome transport|G-protein coupled receptor catabolic process GPRASP2 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 2.47898 2.63738 3.02113 2.64818 GeneID:114928,Genbank:NM_001184876.2,HGNC:HGNC:25169,MIM:300969 G protein-coupled receptor associated sorting protein 2 GO:0001540,GO:0005737 amyloid-beta binding|cytoplasm GPRC5A 341.179236966071 338.739097951886 343.619375980255 1.01440718847596 0.0206368741130951 0.93830171446812 1 5.85586 6.34435 6.72872 5.67472 GeneID:9052,Genbank:NM_003979.3,HGNC:HGNC:9836,MIM:604138 G protein-coupled receptor class C group 5 member A GO:0004930,GO:0005730,GO:0005886,GO:0005887,GO:0007165,GO:0007175,GO:0030659,GO:0031982,GO:0043231,GO:0045296,GO:0070062 G-protein coupled receptor activity|nucleolus|plasma membrane|integral component of plasma membrane|signal transduction|negative regulation of epidermal growth factor-activated receptor activity|cytoplasmic vesicle membrane|vesicle|intracellular membrane-bounded organelle|cadherin binding|extracellular exosome GPRC5B 630.746487932357 495.270737927568 766.222237937147 1.54707754619899 0.629545512696992 0.000160373045716238 0.0305777940498961 5.58527 5.68355 9.60922 8.3405 GeneID:51704,Genbank:XM_006721052.2,HGNC:HGNC:13308,MIM:605948 G protein-coupled receptor class C group 5 member B GO:0001664,GO:0004930,GO:0005615,GO:0005634,GO:0005730,GO:0005829,GO:0005886,GO:0009986,GO:0016021,GO:0019901,GO:0030295,GO:0030659,GO:0043123,GO:0043231,GO:0045666,GO:0050729,GO:0060907,GO:0061098,GO:0070062,GO:0090263 G-protein coupled receptor binding|G-protein coupled receptor activity|extracellular space|nucleus|nucleolus|cytosol|plasma membrane|cell surface|integral component of membrane|protein kinase binding|protein kinase activator activity|cytoplasmic vesicle membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|positive regulation of neuron differentiation|positive regulation of inflammatory response|positive regulation of macrophage cytokine production|positive regulation of protein tyrosine kinase activity|extracellular exosome|positive regulation of canonical Wnt signaling pathway GPRC5C 2.4614274126771 2.49838328447175 2.42447154088245 0.97041617111006 -0.043324503017252 1 1 0.00908423 0.0235432 0.0336457 0.0078834 GeneID:55890,Genbank:XM_005257514.2,HGNC:HGNC:13309,MIM:605949 G protein-coupled receptor class C group 5 member C GO:0004930,GO:0005887,GO:0007186,GO:0030659,GO:0031982,GO:0043235,GO:0070062 G-protein coupled receptor activity|integral component of plasma membrane|G-protein coupled receptor signaling pathway|cytoplasmic vesicle membrane|vesicle|receptor complex|extracellular exosome GPRIN1 776.67129034042 751.304455809101 802.038124871738 1.06752744332922 0.0942731582261439 0.566018913375839 1 6.7369 7.03399 7.40636 7.49182 GeneID:114787,Genbank:NM_052899.2,HGNC:HGNC:24835,MIM:611239 G protein regulated inducer of neurite outgrowth 1 GO:0005886,GO:0030426,GO:0031175 plasma membrane|growth cone|neuron projection development GPRIN3 3.48622496953828 4.06465003971372 2.90779989936283 0.715387516994606 -0.483203150341056 0.844725913131162 1 0.0083023 0.0132912 0.00799946 0.00744321 GeneID:285513,Genbank:XM_017008044.1,HGNC:HGNC:27733,MIM:611241 GPRIN family member 3 GPS1 3438.73190551915 3542.85724979722 3334.60656124107 0.941219565488259 -0.0873967841641881 0.496129635588823 1 21.0966 22.4041 20.481 20.8367 GeneID:2873,Genbank:XM_024450726.1,HGNC:HGNC:4549,MIM:601934 G protein pathway suppressor 1 GO:0000188,GO:0000338,GO:0000715,GO:0005095,GO:0005654,GO:0005829,GO:0006283,GO:0007049,GO:0007254,GO:0008180,GO:0043687 inactivation of MAPK activity|protein deneddylation|nucleotide-excision repair, DNA damage recognition|GTPase inhibitor activity|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|cell cycle|JNK cascade|COP9 signalosome|post-translational protein modification GPS2 1578.08060993588 1559.36012469503 1596.80109517672 1.02401047063392 0.0342304671488461 0.827143090951664 1 34.1335 35.7944 36.0899 36.241 GeneID:2874,Genbank:NM_004489.4,HGNC:HGNC:4550,MIM:601935 G protein pathway suppressor 2 GO:0000122,GO:0000188,GO:0003714,GO:0005095,GO:0005634,GO:0005654,GO:0007049,GO:0007254,GO:0017053,GO:0030332,GO:0045599,GO:0046329 negative regulation of transcription from RNA polymerase II promoter|inactivation of MAPK activity|transcription corepressor activity|GTPase inhibitor activity|nucleus|nucleoplasm|cell cycle|JNK cascade|transcriptional repressor complex|cyclin binding|negative regulation of fat cell differentiation|negative regulation of JNK cascade hsa05166 Human T-cell leukemia virus 1 infection GPSM1 420.266933024752 424.721090356779 415.812775692724 0.979025494927574 -0.0305816651639491 0.857460843568846 1 2.73319 2.76743 2.67022 2.70262 GeneID:26086,Genbank:NM_001145638.2,HGNC:HGNC:17858,MIM:609491 G protein signaling modulator 1 GO:0000139,GO:0005092,GO:0005789,GO:0005829,GO:0005886,GO:0007399,GO:0016239,GO:0030154,GO:0034260,GO:0043234,GO:1905098 Golgi membrane|GDP-dissociation inhibitor activity|endoplasmic reticulum membrane|cytosol|plasma membrane|nervous system development|positive regulation of macroautophagy|cell differentiation|negative regulation of GTPase activity|protein complex|negative regulation of guanyl-nucleotide exchange factor activity hsa05030 Cocaine addiction GPSM2 1004.830852445 995.248050774261 1014.41365411574 1.0192571121607 0.0275180236826517 0.841787715678943 1 4.44288 4.07632 4.88358 3.99152 GeneID:29899,Genbank:XM_011541301.2,HGNC:HGNC:29501,MIM:609245 G protein signaling modulator 2 GO:0000132,GO:0000166,GO:0001965,GO:0005092,GO:0005737,GO:0005813,GO:0005829,GO:0005938,GO:0007052,GO:0007186,GO:0008022,GO:0016328,GO:0019904,GO:0031291,GO:0042802,GO:0043234,GO:0043621,GO:0051301,GO:0051661,GO:0060236,GO:0070840,GO:0097431,GO:0097575,GO:0099738,GO:1904778,GO:1905832 establishment of mitotic spindle orientation|nucleotide binding|G-protein alpha-subunit binding|GDP-dissociation inhibitor activity|cytoplasm|centrosome|cytosol|cell cortex|mitotic spindle organization|G-protein coupled receptor signaling pathway|protein C-terminus binding|lateral plasma membrane|protein domain specific binding|Ran protein signal transduction|identical protein binding|protein complex|protein self-association|cell division|maintenance of centrosome location|regulation of mitotic spindle organization|dynein complex binding|mitotic spindle pole|lateral cell cortex|cell cortex region|positive regulation of protein localization to cell cortex|positive regulation of spindle assembly GPSM3 23.5433893030905 27.2224674455487 19.8643111606322 0.729702816262542 -0.454619073085557 0.453433666989674 1 0.432813 0.453581 0.200312 0.427926 GeneID:63940,Genbank:NM_022107.2,HGNC:HGNC:13945 G protein signaling modulator 3 GO:0002690,GO:0005737,GO:0005886,GO:0030695,GO:1900017 positive regulation of leukocyte chemotaxis|cytoplasm|plasma membrane|GTPase regulator activity|positive regulation of cytokine production involved in inflammatory response GPT 1.21386734807293 0.490071401957362 1.93766329418849 3.95383873951713 1.98325403079315 0.683591311517638 1 0 0 0 0 GeneID:2875,Genbank:XM_011516993.2,HGNC:HGNC:4552,MIM:138200 glutamic--pyruvic transaminase hsa00220,hsa00250 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism GPT2 1654.70887075019 1564.36669991908 1745.05104158129 1.11549999221509 0.157690503513703 0.280328148382833 1 14.1088 14.934 15.613 17.0841 GeneID:84706,Genbank:NM_133443.3,HGNC:HGNC:18062,MIM:138210 glutamic--pyruvic transaminase 2 GO:0004021,GO:0005759,GO:0006103,GO:0008652,GO:0030170,GO:0042851,GO:0042853 L-alanine:2-oxoglutarate aminotransferase activity|mitochondrial matrix|2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|pyridoxal phosphate binding|L-alanine metabolic process|L-alanine catabolic process hsa00220,hsa00250 Arginine biosynthesis|Alanine, aspartate and glutamate metabolism GPX1 10990.9951599512 11014.7243288204 10967.265991082 0.995691373081911 -0.0062294645650601 0.948910889657546 1 398.144 439.644 402.722 465.181 GeneID:2876,Genbank:NM_001329455.1,HGNC:HGNC:4553,MIM:138320 glutathione peroxidase 1 GO:0004602,GO:0005737,GO:0006979 glutathione peroxidase activity|cytoplasm|response to oxidative stress hsa00480,hsa00590,hsa04918,hsa05014,hsa05016 Glutathione metabolism|Arachidonic acid metabolism|Thyroid hormone synthesis|Amyotrophic lateral sclerosis (ALS)|Huntington disease GPX3 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0 0 GeneID:2878,Genbank:NM_001329790.1,HGNC:HGNC:4555,MIM:138321 glutathione peroxidase 3 hsa00480,hsa00590,hsa04918 Glutathione metabolism|Arachidonic acid metabolism|Thyroid hormone synthesis GPX4 7272.17076276879 7027.91753413051 7516.42399140707 1.06950941796118 0.096949186744248 0.640828604144972 1 136.94 152.104 147.34 172.141 GeneID:2879,Genbank:NM_001039847.2,HGNC:HGNC:4556,MIM:138322 glutathione peroxidase 4 hsa00480,hsa04216 Glutathione metabolism|Ferroptosis GPX5 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0501282 0 0 GeneID:2880,Genbank:NM_001509.2,HGNC:HGNC:4557,MIM:603435 glutathione peroxidase 5 hsa00480,hsa00590,hsa04918 Glutathione metabolism|Arachidonic acid metabolism|Thyroid hormone synthesis GPX8 1621.69694612115 1614.48520208512 1628.90869015719 1.00893380010758 0.0128315169718265 0.917330840228816 1 14.8124 14.6218 15.89 13.6368 GeneID:493869,Genbank:NM_001008397.3,HGNC:HGNC:33100,MIM:617172 glutathione peroxidase 8 (putative) GO:0004601,GO:0004602,GO:0005788,GO:0016021,GO:0034599 peroxidase activity|glutathione peroxidase activity|endoplasmic reticulum lumen|integral component of membrane|cellular response to oxidative stress hsa00480,hsa00590,hsa04918 Glutathione metabolism|Arachidonic acid metabolism|Thyroid hormone synthesis GRAMD1A 1212.35177916781 1314.05014272677 1110.65341560886 0.845213876925698 -0.242611640904218 0.164475091143504 1 9.04586 8.50288 6.72718 8.61056 GeneID:57655,Genbank:XM_011527153.1,HGNC:HGNC:29305 GRAM domain containing 1A GO:0016021 integral component of membrane GRAMD1B 29.5719861647489 30.066843307923 29.0771290215749 0.967082866790765 -0.0482885791398292 0.946428984848852 1 0.0448101 0.0651174 0.0526839 0.0529686 GeneID:57476,Genbank:XM_017018041.1,HGNC:HGNC:29214 GRAM domain containing 1B GO:0016020,GO:0016021 membrane|integral component of membrane GRAMD1C 15.8393121492915 17.6229531602492 14.0556711383338 0.797577512152625 -0.326303361634771 0.696739910219823 1 0.103456 0.0587395 0.125179 0.101072 GeneID:54762,Genbank:XM_011512930.1,HGNC:HGNC:25252 GRAM domain containing 1C GO:0016021 integral component of membrane GRAMD2A 1.21430233409962 0.490071401957362 1.93853326624189 3.95561393400904 1.98390162663545 0.683537482026705 1 0 0.00813147 0.00844545 0.00788686 GeneID:196996,Genbank:NM_001012642.2,HGNC:HGNC:27287 GRAM domain containing 2A GO:0016021 integral component of membrane GRAMD2B 640.330913592797 613.730696029739 666.931131155854 1.08668367978052 0.119932050737814 0.53702599503232 1 2.97184 3.03555 3.94736 2.95092 GeneID:65983,Genbank:NM_001146319.2,HGNC:HGNC:24911 GRAM domain containing 2B GO:0005881,GO:0042802 cytoplasmic microtubule|identical protein binding GRAMD4 422.036868800756 410.316914601276 433.756823000236 1.05712635176578 0.0801478234298073 0.672543808625505 1 2.7955 2.97907 3.25717 2.98832 GeneID:23151,Genbank:XM_006724169.1,HGNC:HGNC:29113,MIM:613691 GRAM domain containing 4 GO:0005739,GO:0006915,GO:0016021,GO:0031966,GO:0043280 mitochondrion|apoptotic process|integral component of membrane|mitochondrial membrane|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GRAP 6.58506576349097 8.81147658012458 4.35865494685735 0.494656588736655 -1.01550080133877 0.412361584617676 1 0.200639 0.123304 0.0186907 0.140118 GeneID:10750,Genbank:NM_001330148.1,HGNC:HGNC:4562,MIM:604330 GRB2 related adaptor protein GO:0004715,GO:0005070,GO:0005102,GO:0005737,GO:0005829,GO:0007169,GO:0007265,GO:0007267,GO:0016477,GO:0030154,GO:0031234,GO:0038083,GO:0042127,GO:0045087 non-membrane spanning protein tyrosine kinase activity|SH3/SH2 adaptor activity|receptor binding|cytoplasm|cytosol|transmembrane receptor protein tyrosine kinase signaling pathway|Ras protein signal transduction|cell-cell signaling|cell migration|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|innate immune response GRAP2 4.69508921824101 3.57457863775636 5.81559979872566 1.62693295855869 0.702154802732831 0.673764924339358 1 0.0200462 0.0366997 0.0474023 0.0441698 GeneID:9402,Genbank:XM_006724376.3,HGNC:HGNC:4563,MIM:604518 GRB2 related adaptor protein 2 GO:0004715,GO:0005070,GO:0005102,GO:0005634,GO:0005737,GO:0005768,GO:0005829,GO:0007169,GO:0007265,GO:0007267,GO:0016477,GO:0030154,GO:0031234,GO:0031295,GO:0038083,GO:0038095,GO:0042127,GO:0045087,GO:0050852 non-membrane spanning protein tyrosine kinase activity|SH3/SH2 adaptor activity|receptor binding|nucleus|cytoplasm|endosome|cytosol|transmembrane receptor protein tyrosine kinase signaling pathway|Ras protein signal transduction|cell-cell signaling|cell migration|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|regulation of cell proliferation|innate immune response|T cell receptor signaling pathway hsa04660 T cell receptor signaling pathway GRAPL 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:400581,Genbank:XM_017024635.2,HGNC:HGNC:37240 GRB2 related adaptor protein like GO:0004715,GO:0005070,GO:0005102,GO:0005737,GO:0005829,GO:0007169,GO:0007265,GO:0007267,GO:0016477,GO:0030154,GO:0031234,GO:0038083,GO:0042127,GO:0045087 non-membrane spanning protein tyrosine kinase activity|SH3/SH2 adaptor activity|receptor binding|cytoplasm|cytosol|transmembrane receptor protein tyrosine kinase signaling pathway|Ras protein signal transduction|cell-cell signaling|cell migration|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|innate immune response GRASP 5.47191453841171 4.16070258908361 6.78312648773981 1.6302839105916 0.705123228711136 0.617799445041611 1 0.0207281 0.018078 0.0192159 0.0540402 GeneID:160622,Genbank:NM_181711.3,HGNC:HGNC:18707,MIM:612027 general receptor for phosphoinositides 1 associated scaffold protein GO:0005886,GO:0007165,GO:0008104,GO:0030054,GO:0030165,GO:0030306,GO:0042802,GO:0045211,GO:0048471 plasma membrane|signal transduction|protein localization|cell junction|PDZ domain binding|ADP-ribosylation factor binding|identical protein binding|postsynaptic membrane|perinuclear region of cytoplasm GRB10 3305.02321627365 3215.48279563716 3394.56363691013 1.05569329791344 0.0781907609768496 0.596891725304339 1 8.14849 8.63203 8.29155 9.66033 GeneID:2887,Genbank:NM_001001555.2,HGNC:HGNC:4564,MIM:601523 growth factor receptor bound protein 10 hsa04150 mTOR signaling pathway GRB14 1.80629935685046 2.64246210852658 0.97013660517434 0.367133591828601 -1.44562297133152 0.669282905095046 1 0.0231914 0.0108673 0.0110442 0 GeneID:2888,Genbank:NM_001303422.1,HGNC:HGNC:4565,MIM:601524 growth factor receptor bound protein 14 GO:0005070,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0010008,GO:0030971,GO:0042802,GO:0042803,GO:0043231,GO:0046627,GO:0050900 SH3/SH2 adaptor activity|cytoplasm|cytosol|plasma membrane|signal transduction|endosome membrane|receptor tyrosine kinase binding|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|negative regulation of insulin receptor signaling pathway|leukocyte migration GRB2 5586.66510048891 5530.4051482806 5642.92505269721 1.02034568922163 0.0290580145823341 0.841700835300187 1 67.336 73.0417 73.276 71.7161 GeneID:2885,Genbank:NM_203506.2,HGNC:HGNC:4566,MIM:108355 growth factor receptor bound protein 2 GO:0001784,GO:0003723,GO:0004715,GO:0005070,GO:0005154,GO:0005168,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005768,GO:0005794,GO:0005829,GO:0005886,GO:0005911,GO:0007169,GO:0007265,GO:0007568,GO:0008180,GO:0008286,GO:0008543,GO:0012506,GO:0016020,GO:0016477,GO:0017124,GO:0019899,GO:0019901,GO:0019903,GO:0019904,GO:0030154,GO:0030838,GO:0031234,GO:0031623,GO:0038083,GO:0042127,GO:0042770,GO:0042802,GO:0043234,GO:0043408,GO:0043560,GO:0045087,GO:0046875,GO:0048646,GO:0051219,GO:0051291,GO:0060670,GO:0070062,GO:0070436,GO:0071479,GO:2000379 phosphotyrosine residue binding|RNA binding|non-membrane spanning protein tyrosine kinase activity|SH3/SH2 adaptor activity|epidermal growth factor receptor binding|neurotrophin TRKA receptor binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endosome|Golgi apparatus|cytosol|plasma membrane|cell-cell junction|transmembrane receptor protein tyrosine kinase signaling pathway|Ras protein signal transduction|aging|COP9 signalosome|insulin receptor signaling pathway|fibroblast growth factor receptor signaling pathway|vesicle membrane|membrane|cell migration|SH3 domain binding|enzyme binding|protein kinase binding|protein phosphatase binding|protein domain specific binding|cell differentiation|positive regulation of actin filament polymerization|extrinsic component of cytoplasmic side of plasma membrane|receptor internalization|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|signal transduction in response to DNA damage|identical protein binding|protein complex|regulation of MAPK cascade|insulin receptor substrate binding|innate immune response|ephrin receptor binding|anatomical structure formation involved in morphogenesis|phosphoprotein binding|protein heterooligomerization|branching involved in labyrinthine layer morphogenesis|extracellular exosome|Grb2-EGFR complex|cellular response to ionizing radiation|positive regulation of reactive oxygen species metabolic process hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04062,hsa04068,hsa04072,hsa04150,hsa04151,hsa04380,hsa04510,hsa04540,hsa04550,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04722,hsa04910,hsa04912,hsa04915,hsa04917,hsa04926,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Osteoclast differentiation|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer GRB7 5.21374187088434 5.58289052027075 4.84459322149792 0.867757159827482 -0.204636731168805 0.94456130385235 1 0.0767192 0.100069 0.0531664 0.0998841 GeneID:2886,Genbank:NM_001330207.1,HGNC:HGNC:4567,MIM:601522 growth factor receptor bound protein 7 GO:0003723,GO:0005070,GO:0005829,GO:0005886,GO:0005925,GO:0007173,GO:0007411,GO:0010494,GO:0017148,GO:0019901,GO:0030335,GO:0034063,GO:0035091,GO:0038128,GO:0042802,GO:0042995,GO:0050900 RNA binding|SH3/SH2 adaptor activity|cytosol|plasma membrane|focal adhesion|epidermal growth factor receptor signaling pathway|axon guidance|cytoplasmic stress granule|negative regulation of translation|protein kinase binding|positive regulation of cell migration|stress granule assembly|phosphatidylinositol binding|ERBB2 signaling pathway|identical protein binding|cell projection|leukocyte migration GREB1 10.0003155251517 8.36943145285216 11.6311995974513 1.38972398101039 0.474798371603395 0.617857532203656 1 0.0283066 0.0103364 0.0294652 0.0299867 GeneID:9687,Genbank:XM_024453254.1,HGNC:HGNC:24885,MIM:611736 growth regulation by estrogen in breast cancer 1 GREM2 3.92914006886409 4.94874029425856 2.90953984346962 0.58793544830898 -0.7662703301604 0.709931714099474 1 0.00972944 0.0814832 0.0277224 0.00860468 GeneID:64388,Genbank:XM_011544249.2,HGNC:HGNC:17655,MIM:608832 gremlin 2, DAN family BMP antagonist GO:0005125,GO:0005576,GO:0005615,GO:0008201,GO:0010172,GO:0019221,GO:0030509,GO:0036122,GO:0038098,GO:0042803,GO:0048263,GO:0060300 cytokine activity|extracellular region|extracellular space|heparin binding|embryonic body morphogenesis|cytokine-mediated signaling pathway|BMP signaling pathway|BMP binding|sequestering of BMP from receptor via BMP binding|protein homodimerization activity|determination of dorsal identity|regulation of cytokine activity GRHL1 19.3096578486658 18.7471747882187 19.8721409091128 1.06000723488219 0.084074111668698 0.911958533502835 1 0.204008 0.100272 0.153324 0.133374 GeneID:29841,Genbank:NM_198182.2,HGNC:HGNC:17923,MIM:609786 grainyhead like transcription factor 1 GO:0000978,GO:0001077,GO:0002934,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0008544,GO:0019216,GO:0031490,GO:0043231,GO:0043565,GO:0044212,GO:0045616,GO:0045944,GO:0061436 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|desmosome organization|nucleus|nucleoplasm|Golgi apparatus|cytosol|epidermis development|regulation of lipid metabolic process|chromatin DNA binding|intracellular membrane-bounded organelle|sequence-specific DNA binding|transcription regulatory region DNA binding|regulation of keratinocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|establishment of skin barrier GRHL3 8.33136154353799 3.57457863775636 13.0881444493196 3.66145097804719 1.8724154802041 0.0788318668488604 0.945231254824065 0.0225018 0.0202355 0.0737845 0.0197018 GeneID:57822,Genbank:NM_198174.2,HGNC:HGNC:25839,MIM:608317 grainyhead like transcription factor 3 GO:0001228,GO:0001736,GO:0001843,GO:0005634,GO:0005654,GO:0007389,GO:0007398,GO:0007417,GO:0008544,GO:0031490,GO:0032956,GO:0042060,GO:0043547,GO:0043565,GO:0045944,GO:0061029,GO:0061436,GO:0090103,GO:0090179 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|establishment of planar polarity|neural tube closure|nucleus|nucleoplasm|pattern specification process|ectoderm development|central nervous system development|epidermis development|chromatin DNA binding|regulation of actin cytoskeleton organization|wound healing|positive regulation of GTPase activity|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|eyelid development in camera-type eye|establishment of skin barrier|cochlea morphogenesis|planar cell polarity pathway involved in neural tube closure GRHPR 2378.64923836246 2375.51668469592 2381.781792029 1.00263736616688 0.003799906417339 0.99778234128033 1 14.5924 15.3544 14.6905 16.5346 GeneID:9380,Genbank:XM_024447716.1,HGNC:HGNC:4570,MIM:604296 glyoxylate and hydroxypyruvate reductase GO:0005737,GO:0005782,GO:0005829,GO:0007588,GO:0008152,GO:0008465,GO:0016618,GO:0030267,GO:0031406,GO:0034641,GO:0042803,GO:0043648,GO:0051259,GO:0051287,GO:0055114,GO:0070062,GO:0070402 cytoplasm|peroxisomal matrix|cytosol|excretion|metabolic process|glycerate dehydrogenase activity|hydroxypyruvate reductase activity|glyoxylate reductase (NADP) activity|carboxylic acid binding|cellular nitrogen compound metabolic process|protein homodimerization activity|dicarboxylic acid metabolic process|protein oligomerization|NAD binding|oxidation-reduction process|extracellular exosome|NADPH binding hsa00260,hsa00620,hsa00630 Glycine, serine and threonine metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism GRIA1 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0.00633078 0.0234938 0 0 GeneID:2890,Genbank:NM_001258020.1,HGNC:HGNC:4571,MIM:138248 glutamate ionotropic receptor AMPA type subunit 1 GO:0000139,GO:0001540,GO:0004971,GO:0005231,GO:0005234,GO:0005789,GO:0005886,GO:0006888,GO:0007165,GO:0007268,GO:0007616,GO:0008021,GO:0008066,GO:0009986,GO:0012507,GO:0014069,GO:0030054,GO:0030165,GO:0030425,GO:0030666,GO:0031623,GO:0031901,GO:0032281,GO:0032591,GO:0033116,GO:0043025,GO:0043197,GO:0044308,GO:0044309,GO:0048208,GO:0055037,GO:0055038,GO:0060292,GO:0098839,GO:0099583,GO:1904315 Golgi membrane|amyloid-beta binding|AMPA glutamate receptor activity|excitatory extracellular ligand-gated ion channel activity|extracellularly glutamate-gated ion channel activity|endoplasmic reticulum membrane|plasma membrane|ER to Golgi vesicle-mediated transport|signal transduction|chemical synaptic transmission|long-term memory|synaptic vesicle|glutamate receptor activity|cell surface|ER to Golgi transport vesicle membrane|postsynaptic density|cell junction|PDZ domain binding|dendrite|endocytic vesicle membrane|receptor internalization|early endosome membrane|AMPA glutamate receptor complex|dendritic spine membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|neuronal cell body|dendritic spine|axonal spine|neuron spine|COPII vesicle coating|recycling endosome|recycling endosome membrane|long term synaptic depression|postsynaptic density membrane|neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration|transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential hsa04024,hsa04080,hsa04713,hsa04720,hsa04723,hsa04724,hsa04728,hsa04730,hsa05014,hsa05031,hsa05033 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Dopaminergic synapse|Long-term depression|Amyotrophic lateral sclerosis (ALS)|Amphetamine addiction|Nicotine addiction GRIA2 1.7764131480844 1.61429302992691 1.93853326624189 1.20085587331666 0.264063009221118 1 1 0.0146777 0 0 0.013169 GeneID:2891,Genbank:NM_001083619.1,HGNC:HGNC:4572,MIM:138247 glutamate ionotropic receptor AMPA type subunit 2 GO:0004970,GO:0004971,GO:0005234,GO:0005789,GO:0005887,GO:0015277,GO:0030054,GO:0032281,GO:0035235,GO:0045211 ionotropic glutamate receptor activity|AMPA glutamate receptor activity|extracellularly glutamate-gated ion channel activity|endoplasmic reticulum membrane|integral component of plasma membrane|kainate selective glutamate receptor activity|cell junction|AMPA glutamate receptor complex|ionotropic glutamate receptor signaling pathway|postsynaptic membrane hsa04024,hsa04080,hsa04713,hsa04720,hsa04723,hsa04724,hsa04728,hsa04730,hsa05014,hsa05030,hsa05031,hsa05033 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Dopaminergic synapse|Long-term depression|Amyotrophic lateral sclerosis (ALS)|Cocaine addiction|Amphetamine addiction|Nicotine addiction GRIA3 3.27357702701075 5.09281911831339 1.45433493570811 0.285565794095933 -1.80810491539295 0.337675799381869 1 0.00680607 0.0320766 0.0130441 0.00605063 GeneID:2892,Genbank:NM_000828.4,HGNC:HGNC:4573,MIM:305915 glutamate ionotropic receptor AMPA type subunit 3 GO:0001540,GO:0004971,GO:0005231,GO:0005234,GO:0005886,GO:0006810,GO:0007215,GO:0030054,GO:0030666,GO:0032281,GO:0045211 amyloid-beta binding|AMPA glutamate receptor activity|excitatory extracellular ligand-gated ion channel activity|extracellularly glutamate-gated ion channel activity|plasma membrane|transport|glutamate receptor signaling pathway|cell junction|endocytic vesicle membrane|AMPA glutamate receptor complex|postsynaptic membrane hsa04024,hsa04080,hsa04713,hsa04723,hsa04724,hsa04728,hsa04730,hsa05031,hsa05033,hsa05202 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Dopaminergic synapse|Long-term depression|Amphetamine addiction|Nicotine addiction|Transcriptional misregulation in cancer GRIA4 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0.00244146 0 0 0.00220088 GeneID:2893,Genbank:XM_024448455.1,HGNC:HGNC:4574,MIM:138246 glutamate ionotropic receptor AMPA type subunit 4 GO:0004970,GO:0004971,GO:0005231,GO:0005234,GO:0005886,GO:0006810,GO:0007215,GO:0030054,GO:0030666,GO:0032281,GO:0043025,GO:0043197,GO:0045211,GO:1903561 ionotropic glutamate receptor activity|AMPA glutamate receptor activity|excitatory extracellular ligand-gated ion channel activity|extracellularly glutamate-gated ion channel activity|plasma membrane|transport|glutamate receptor signaling pathway|cell junction|endocytic vesicle membrane|AMPA glutamate receptor complex|neuronal cell body|dendritic spine|postsynaptic membrane|extracellular vesicle hsa04024,hsa04080,hsa04713,hsa04723,hsa04724,hsa04728,hsa05031,hsa05033 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Dopaminergic synapse|Amphetamine addiction|Nicotine addiction GRID1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00697118 0 0 0 GeneID:2894,Genbank:NM_017551.2,HGNC:HGNC:4575,MIM:610659 glutamate ionotropic receptor delta type subunit 1 GO:0004970,GO:0005234,GO:0016021,GO:0030054,GO:0035176,GO:0045211,GO:0070062 ionotropic glutamate receptor activity|extracellularly glutamate-gated ion channel activity|integral component of membrane|cell junction|social behavior|postsynaptic membrane|extracellular exosome hsa04080 Neuroactive ligand-receptor interaction GRID2 7.19779986212607 5.18887166768327 9.20672805656886 1.77432178828186 0.827267678330503 0.471665420947495 1 0.00820264 0.00795098 0.0138921 0.0166239 GeneID:2895,Genbank:XM_024454024.1,HGNC:HGNC:4576,MIM:602368 glutamate ionotropic receptor delta type subunit 2 GO:0004970,GO:0005234,GO:0005886,GO:0005887,GO:0006810,GO:0007157,GO:0007215,GO:0008066,GO:0008328,GO:0010975,GO:0021707,GO:0030054,GO:0030165,GO:0034613,GO:0035249,GO:0043197,GO:0043523,GO:0045202,GO:0045211,GO:0051965,GO:0060079,GO:0060134,GO:0097110,GO:1900454,GO:1904861 ionotropic glutamate receptor activity|extracellularly glutamate-gated ion channel activity|plasma membrane|integral component of plasma membrane|transport|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|glutamate receptor signaling pathway|glutamate receptor activity|ionotropic glutamate receptor complex|regulation of neuron projection development|cerebellar granule cell differentiation|cell junction|PDZ domain binding|cellular protein localization|synaptic transmission, glutamatergic|dendritic spine|regulation of neuron apoptotic process|synapse|postsynaptic membrane|positive regulation of synapse assembly|excitatory postsynaptic potential|prepulse inhibition|scaffold protein binding|positive regulation of long term synaptic depression|excitatory synapse assembly hsa04080,hsa04730 Neuroactive ligand-receptor interaction|Long-term depression GRID2IP 1.48335117242078 1.02816907859967 1.93853326624189 1.88542264749112 0.914887962799843 0.868258168018795 1 0.0106007 0 0.0194236 0.0181814 GeneID:392862,Genbank:NM_001145118.1,HGNC:HGNC:18464,MIM:610639 Grid2 interacting protein GO:0030054,GO:0043197,GO:0045211,GO:0060292 cell junction|dendritic spine|postsynaptic membrane|long term synaptic depression GRIFIN 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:402635,Genbank:XM_011515405.2,HGNC:HGNC:4577 galectin-related inter-fiber protein GO:0030246 carbohydrate binding GRIK1 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0 0 0 0.0055297 GeneID:2897,Genbank:NM_001320621.1,HGNC:HGNC:4579,MIM:138245 glutamate ionotropic receptor kainate type subunit 1 GO:0005234,GO:0005886,GO:0005887,GO:0006810,GO:0007215,GO:0007268,GO:0007399,GO:0007417,GO:0015276,GO:0015277,GO:0030054,GO:0045211,GO:0051966 extracellularly glutamate-gated ion channel activity|plasma membrane|integral component of plasma membrane|transport|glutamate receptor signaling pathway|chemical synaptic transmission|nervous system development|central nervous system development|ligand-gated ion channel activity|kainate selective glutamate receptor activity|cell junction|postsynaptic membrane|regulation of synaptic transmission, glutamatergic hsa04080,hsa04724 Neuroactive ligand-receptor interaction|Glutamatergic synapse GRIK2 628.087112979598 559.236717863102 696.937508096094 1.24622988053996 0.317570213566681 0.0735747376232861 0.934750619674839 1.46716 1.27413 1.99473 1.57501 GeneID:2898,Genbank:XM_024446411.1,HGNC:HGNC:4580,MIM:138244 glutamate ionotropic receptor kainate type subunit 2 GO:0001662,GO:0005234,GO:0005886,GO:0005887,GO:0006810,GO:0006874,GO:0006886,GO:0007215,GO:0007268,GO:0014069,GO:0015276,GO:0015277,GO:0019228,GO:0030054,GO:0030165,GO:0031624,GO:0031625,GO:0032839,GO:0032983,GO:0035249,GO:0042734,GO:0042803,GO:0043113,GO:0043195,GO:0043204,GO:0043524,GO:0043525,GO:0045211,GO:0046328,GO:0048169,GO:0048172,GO:0050804,GO:0050806,GO:0051402,GO:0051967,GO:0060080 behavioral fear response|extracellularly glutamate-gated ion channel activity|plasma membrane|integral component of plasma membrane|transport|cellular calcium ion homeostasis|intracellular protein transport|glutamate receptor signaling pathway|chemical synaptic transmission|postsynaptic density|ligand-gated ion channel activity|kainate selective glutamate receptor activity|neuronal action potential|cell junction|PDZ domain binding|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|dendrite cytoplasm|kainate selective glutamate receptor complex|synaptic transmission, glutamatergic|presynaptic membrane|protein homodimerization activity|receptor clustering|terminal bouton|perikaryon|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|postsynaptic membrane|regulation of JNK cascade|regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|modulation of chemical synaptic transmission|positive regulation of synaptic transmission|neuron apoptotic process|negative regulation of synaptic transmission, glutamatergic|inhibitory postsynaptic potential hsa04080,hsa04724 Neuroactive ligand-receptor interaction|Glutamatergic synapse GRIK3 21.2610840159902 6.169014471598 36.3531535603824 5.89286242198839 2.5589685846297 0.000138878030659634 0.0281553232790469 0.0211888 0.0190442 0.151663 0.100551 GeneID:2899,Genbank:NM_000831.3,HGNC:HGNC:4581,MIM:138243 glutamate ionotropic receptor kainate type subunit 3 GO:0001640,GO:0001664,GO:0004970,GO:0005234,GO:0005886,GO:0005887,GO:0007215,GO:0007216,GO:0008066,GO:0015276,GO:0015277,GO:0030054,GO:0030424,GO:0030425,GO:0032839,GO:0042391,GO:0043195,GO:0043204,GO:0045211,GO:0051967 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity|G-protein coupled receptor binding|ionotropic glutamate receptor activity|extracellularly glutamate-gated ion channel activity|plasma membrane|integral component of plasma membrane|glutamate receptor signaling pathway|G-protein coupled glutamate receptor signaling pathway|glutamate receptor activity|ligand-gated ion channel activity|kainate selective glutamate receptor activity|cell junction|axon|dendrite|dendrite cytoplasm|regulation of membrane potential|terminal bouton|perikaryon|postsynaptic membrane|negative regulation of synaptic transmission, glutamatergic hsa04080,hsa04724 Neuroactive ligand-receptor interaction|Glutamatergic synapse GRIK4 77.8720839348388 77.2283507545608 78.5158171151168 1.01667090321076 0.0238527537856016 0.998932049807089 1 0.193232 0.283284 0.295218 0.222925 GeneID:2900,Genbank:NM_014619.4,HGNC:HGNC:4582,MIM:600282 glutamate ionotropic receptor kainate type subunit 4 GO:0005234,GO:0005886,GO:0005887,GO:0006810,GO:0007215,GO:0007268,GO:0015276,GO:0015277,GO:0030054,GO:0032983,GO:0042734,GO:0045211 extracellularly glutamate-gated ion channel activity|plasma membrane|integral component of plasma membrane|transport|glutamate receptor signaling pathway|chemical synaptic transmission|ligand-gated ion channel activity|kainate selective glutamate receptor activity|cell junction|kainate selective glutamate receptor complex|presynaptic membrane|postsynaptic membrane hsa04080,hsa04724 Neuroactive ligand-receptor interaction|Glutamatergic synapse GRIK5 5.42269167212176 3.57457863775636 7.27080470648717 2.03403126446557 1.02434185458518 0.464026466804877 1 0.0119317 0.0103682 0.0332358 0.0155474 GeneID:2901,Genbank:XM_005258821.3,HGNC:HGNC:4583,MIM:600283 glutamate ionotropic receptor kainate type subunit 5 GO:0005234,GO:0005634,GO:0005783,GO:0005886,GO:0006621,GO:0014069,GO:0015276,GO:0015277,GO:0017124,GO:0030054,GO:0030165,GO:0030425,GO:0031630,GO:0032983,GO:0035249,GO:0042734,GO:0042802,GO:0043113,GO:0043195,GO:0043204,GO:0043525,GO:0045211,GO:0051649,GO:0071333 extracellularly glutamate-gated ion channel activity|nucleus|endoplasmic reticulum|plasma membrane|protein retention in ER lumen|postsynaptic density|ligand-gated ion channel activity|kainate selective glutamate receptor activity|SH3 domain binding|cell junction|PDZ domain binding|dendrite|regulation of synaptic vesicle fusion to presynaptic active zone membrane|kainate selective glutamate receptor complex|synaptic transmission, glutamatergic|presynaptic membrane|identical protein binding|receptor clustering|terminal bouton|perikaryon|positive regulation of neuron apoptotic process|postsynaptic membrane|establishment of localization in cell|cellular response to glucose stimulus hsa04080,hsa04724 Neuroactive ligand-receptor interaction|Glutamatergic synapse GRIN2A 2.6976535065204 1.51824048055703 3.87706653248377 2.55365772559385 1.35256516925384 0.558012485858825 1 0.0026792 0.00503812 0.0102419 0.00955236 GeneID:2903,Genbank:NM_000833.4,HGNC:HGNC:4585,MIM:138253 glutamate ionotropic receptor NMDA type subunit 2A GO:0000165,GO:0001964,GO:0001975,GO:0004972,GO:0005088,GO:0005234,GO:0005783,GO:0005886,GO:0005887,GO:0006810,GO:0007215,GO:0007268,GO:0007420,GO:0007611,GO:0007613,GO:0008021,GO:0008104,GO:0008270,GO:0008542,GO:0009611,GO:0009986,GO:0014069,GO:0017146,GO:0019233,GO:0022008,GO:0022849,GO:0030054,GO:0030431,GO:0033058,GO:0042177,GO:0042417,GO:0042428,GO:0042734,GO:0043005,GO:0043065,GO:0045471,GO:0048167,GO:0051930,GO:0060291,GO:0097202,GO:0097553,GO:0098976,GO:0099061,GO:1900273 MAPK cascade|startle response|response to amphetamine|NMDA glutamate receptor activity|Ras guanyl-nucleotide exchange factor activity|extracellularly glutamate-gated ion channel activity|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|transport|glutamate receptor signaling pathway|chemical synaptic transmission|brain development|learning or memory|memory|synaptic vesicle|protein localization|zinc ion binding|visual learning|response to wounding|cell surface|postsynaptic density|NMDA selective glutamate receptor complex|sensory perception of pain|neurogenesis|glutamate-gated calcium ion channel activity|cell junction|sleep|directional locomotion|negative regulation of protein catabolic process|dopamine metabolic process|serotonin metabolic process|presynaptic membrane|neuron projection|positive regulation of apoptotic process|response to ethanol|regulation of synaptic plasticity|regulation of sensory perception of pain|long-term synaptic potentiation|activation of cysteine-type endopeptidase activity|calcium ion transmembrane import into cytosol|excitatory chemical synaptic transmission|integral component of postsynaptic density membrane|positive regulation of long-term synaptic potentiation hsa04014,hsa04015,hsa04020,hsa04024,hsa04080,hsa04713,hsa04720,hsa04724,hsa04728,hsa05010,hsa05014,hsa05030,hsa05031,hsa05033,hsa05034,hsa05322 Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Long-term potentiation|Glutamatergic synapse|Dopaminergic synapse|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Cocaine addiction|Amphetamine addiction|Nicotine addiction|Alcoholism|Systemic lupus erythematosus GRIN2B 23.5552068852379 18.507043414794 28.6033703556819 1.54553970153964 0.628110714357046 0.391972001044864 1 0.0210879 0.0187099 0.0416834 0.0188499 GeneID:2904,Genbank:XM_011520629.2,HGNC:HGNC:4586,MIM:138252 glutamate ionotropic receptor NMDA type subunit 2B GO:0000165,GO:0004972,GO:0005088,GO:0005234,GO:0005622,GO:0005886,GO:0005887,GO:0006810,GO:0007215,GO:0007268,GO:0007275,GO:0007420,GO:0007611,GO:0008270,GO:0009986,GO:0014069,GO:0016594,GO:0016595,GO:0017146,GO:0022849,GO:0030054,GO:0043005,GO:0045211,GO:0045471,GO:0048013,GO:0048167,GO:0051290,GO:0097553,GO:0098976,GO:1901216,GO:1902951,GO:2001056 MAPK cascade|NMDA glutamate receptor activity|Ras guanyl-nucleotide exchange factor activity|extracellularly glutamate-gated ion channel activity|intracellular|plasma membrane|integral component of plasma membrane|transport|glutamate receptor signaling pathway|chemical synaptic transmission|multicellular organism development|brain development|learning or memory|zinc ion binding|cell surface|postsynaptic density|glycine binding|glutamate binding|NMDA selective glutamate receptor complex|glutamate-gated calcium ion channel activity|cell junction|neuron projection|postsynaptic membrane|response to ethanol|ephrin receptor signaling pathway|regulation of synaptic plasticity|protein heterotetramerization|calcium ion transmembrane import into cytosol|excitatory chemical synaptic transmission|positive regulation of neuron death|negative regulation of dendritic spine maintenance|positive regulation of cysteine-type endopeptidase activity hsa04014,hsa04015,hsa04024,hsa04080,hsa04713,hsa04720,hsa04724,hsa04728,hsa05010,hsa05014,hsa05016,hsa05030,hsa05031,hsa05033,hsa05034,hsa05322 Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Long-term potentiation|Glutamatergic synapse|Dopaminergic synapse|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Huntington disease|Cocaine addiction|Amphetamine addiction|Nicotine addiction|Alcoholism|Systemic lupus erythematosus GRIN2C 1.45683648539321 0.490071401957362 2.42360156882906 4.94540501475725 2.30608867848779 0.553970604158029 1 0 0 0.0110857 0.0103471 GeneID:2905,Genbank:XM_011524689.2,HGNC:HGNC:4587,MIM:138254 glutamate ionotropic receptor NMDA type subunit 2C GO:0000165,GO:0004972,GO:0005088,GO:0005234,GO:0005622,GO:0005886,GO:0005887,GO:0006810,GO:0007215,GO:0007420,GO:0008104,GO:0009611,GO:0014069,GO:0017146,GO:0022849,GO:0030054,GO:0033058,GO:0042177,GO:0045211,GO:0048167,GO:0050885,GO:0097553,GO:0098976 MAPK cascade|NMDA glutamate receptor activity|Ras guanyl-nucleotide exchange factor activity|extracellularly glutamate-gated ion channel activity|intracellular|plasma membrane|integral component of plasma membrane|transport|glutamate receptor signaling pathway|brain development|protein localization|response to wounding|postsynaptic density|NMDA selective glutamate receptor complex|glutamate-gated calcium ion channel activity|cell junction|directional locomotion|negative regulation of protein catabolic process|postsynaptic membrane|regulation of synaptic plasticity|neuromuscular process controlling balance|calcium ion transmembrane import into cytosol|excitatory chemical synaptic transmission hsa04020,hsa04024,hsa04080,hsa04713,hsa04720,hsa04724,hsa05010,hsa05014,hsa05030,hsa05031,hsa05033,hsa05034 Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Long-term potentiation|Glutamatergic synapse|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Cocaine addiction|Amphetamine addiction|Nicotine addiction|Alcoholism GRIN2D 4.39139182571379 5.39078542153098 3.3919982298966 0.629221526115442 -0.668360067667179 0.768034449697799 1 0 0.0974527 0.0356841 0.0445808 GeneID:2906,Genbank:NM_000836.2,HGNC:HGNC:4588,MIM:602717 glutamate ionotropic receptor NMDA type subunit 2D GO:0000165,GO:0001964,GO:0004970,GO:0004972,GO:0005088,GO:0005234,GO:0005622,GO:0005886,GO:0005887,GO:0007420,GO:0008344,GO:0017146,GO:0022849,GO:0030054,GO:0045211,GO:0048167,GO:0051930,GO:0097553,GO:0098976 MAPK cascade|startle response|ionotropic glutamate receptor activity|NMDA glutamate receptor activity|Ras guanyl-nucleotide exchange factor activity|extracellularly glutamate-gated ion channel activity|intracellular|plasma membrane|integral component of plasma membrane|brain development|adult locomotory behavior|NMDA selective glutamate receptor complex|glutamate-gated calcium ion channel activity|cell junction|postsynaptic membrane|regulation of synaptic plasticity|regulation of sensory perception of pain|calcium ion transmembrane import into cytosol|excitatory chemical synaptic transmission hsa04020,hsa04024,hsa04080,hsa04713,hsa04720,hsa04724,hsa05010,hsa05014,hsa05030,hsa05031,hsa05033,hsa05034 Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Circadian entrainment|Long-term potentiation|Glutamatergic synapse|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Cocaine addiction|Amphetamine addiction|Nicotine addiction|Alcoholism GRIN3A 2.19237857435595 1.96028560782945 2.42447154088245 1.23679505231229 0.306606453014791 1 1 0 0.00993677 0.0134761 0.00314233 GeneID:116443,Genbank:NM_133445.2,HGNC:HGNC:16767,MIM:606650 glutamate ionotropic receptor NMDA type subunit 3A GO:0004972,GO:0005234,GO:0005262,GO:0006816,GO:0014069,GO:0016020,GO:0016021,GO:0016358,GO:0016594,GO:0017146,GO:0030054,GO:0042802,GO:0043005,GO:0043025,GO:0045202,GO:0045211,GO:0045471,GO:0051721,GO:0060134 NMDA glutamate receptor activity|extracellularly glutamate-gated ion channel activity|calcium channel activity|calcium ion transport|postsynaptic density|membrane|integral component of membrane|dendrite development|glycine binding|NMDA selective glutamate receptor complex|cell junction|identical protein binding|neuron projection|neuronal cell body|synapse|postsynaptic membrane|response to ethanol|protein phosphatase 2A binding|prepulse inhibition hsa04024,hsa04080,hsa04724,hsa05030,hsa05031,hsa05033,hsa05034 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Glutamatergic synapse|Cocaine addiction|Amphetamine addiction|Nicotine addiction|Alcoholism GRIN3B 23.8540575868301 25.9061407188394 21.8019744548207 0.841575543475914 -0.24883531494665 0.675852684993329 1 0.0175319 0.0144211 0 0.0148757 GeneID:116444,Genbank:NM_138690.2,HGNC:HGNC:16768,MIM:606651 glutamate ionotropic receptor NMDA type subunit 3B GO:0004970,GO:0005234,GO:0005261,GO:0005262,GO:0016594,GO:0017146,GO:0030054,GO:0030594,GO:0035235,GO:0042165,GO:0043025,GO:0045211,GO:0051205,GO:0051924 ionotropic glutamate receptor activity|extracellularly glutamate-gated ion channel activity|cation channel activity|calcium channel activity|glycine binding|NMDA selective glutamate receptor complex|cell junction|neurotransmitter receptor activity|ionotropic glutamate receptor signaling pathway|neurotransmitter binding|neuronal cell body|postsynaptic membrane|protein insertion into membrane|regulation of calcium ion transport hsa04024,hsa04080,hsa04724,hsa05030,hsa05031,hsa05033,hsa05034 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Glutamatergic synapse|Cocaine addiction|Amphetamine addiction|Nicotine addiction|Alcoholism GRINA 2903.92662446427 2750.17507381475 3057.67817511378 1.11181219124079 0.152913106722451 0.276238005345331 1 57.8041 60.9201 72.5718 62.5608 GeneID:2907,Genbank:NM_000837.1,HGNC:HGNC:4589,MIM:138251 glutamate ionotropic receptor NMDA type subunit associated protein 1 GO:0005783,GO:0005794,GO:0016021,GO:0032469,GO:0044325,GO:1902236 endoplasmic reticulum|Golgi apparatus|integral component of membrane|endoplasmic reticulum calcium ion homeostasis|ion channel binding|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GRIP1 59.2118786142085 59.2976226359861 59.1261345924309 0.997108011486264 -0.00417830220442141 1 1 0.189333 0.200784 0.227962 0.200575 GeneID:23426,Genbank:NM_001178074.1,HGNC:HGNC:18708,MIM:604597 glutamate receptor interacting protein 1 GO:0003713,GO:0005783,GO:0005829,GO:0005886,GO:0008013,GO:0008022,GO:0008104,GO:0016358,GO:0030054,GO:0030159,GO:0030425,GO:0030521,GO:0035259,GO:0035556,GO:0043005,GO:0045121,GO:0045211,GO:0045893,GO:0050681,GO:0055037 transcription coactivator activity|endoplasmic reticulum|cytosol|plasma membrane|beta-catenin binding|protein C-terminus binding|protein localization|dendrite development|cell junction|receptor signaling complex scaffold activity|dendrite|androgen receptor signaling pathway|glucocorticoid receptor binding|intracellular signal transduction|neuron projection|membrane raft|postsynaptic membrane|positive regulation of transcription, DNA-templated|androgen receptor binding|recycling endosome GRIP2 489.077120771814 515.419466335904 462.734775207724 0.897782884486856 -0.155561502199626 0.678912877952599 1 1.72721 1.31185 1.12501 1.63808 GeneID:80852,Genbank:XM_011534142.3,HGNC:HGNC:23841 glutamate receptor interacting protein 2 GO:0005829,GO:0005886,GO:0030159 cytosol|plasma membrane|receptor signaling complex scaffold activity GRIPAP1 776.830429192441 744.81785772407 808.843000660813 1.08596080541407 0.118972034214864 0.45667128603253 1 3.76101 3.75714 4.33746 4.23346 GeneID:56850,Genbank:XM_017029656.1,HGNC:HGNC:18706,MIM:300408 GRIP1 associated protein 1 GO:0005654,GO:0005829,GO:0030054,GO:0030424,GO:0030425,GO:0031901,GO:0043231,GO:0055038,GO:0072562,GO:0098837,GO:0098887,GO:1905244 nucleoplasm|cytosol|cell junction|axon|dendrite|early endosome membrane|intracellular membrane-bounded organelle|recycling endosome membrane|blood microparticle|postsynaptic recycling endosome|neurotransmitter receptor transport, endosome to postsynaptic membrane|regulation of modification of synaptic structure GRK1 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.00833883 0 GeneID:6011,Genbank:XM_017020684.1,HGNC:HGNC:10013,MIM:180381 G protein-coupled receptor kinase 1 hsa04062,hsa04144,hsa04744 Chemokine signaling pathway|Endocytosis|Phototransduction GRK2 1753.27493132653 1743.9885137157 1762.56134893736 1.01064963162062 0.0152829355877408 0.926546618241396 1 20.7448 20.6531 21.2179 21.226 GeneID:156,Genbank:NM_001619.4,HGNC:HGNC:289,MIM:109635 G protein-coupled receptor kinase 2 hsa04062,hsa04144,hsa04340,hsa04724,hsa04740,hsa05032 Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Glutamatergic synapse|Olfactory transduction|Morphine addiction GRK3 192.917687180403 191.479579992963 194.355794367844 1.01502099793089 0.0215095730236632 0.920881937950126 1 0.877089 0.791239 0.961746 0.749277 GeneID:157,Genbank:NM_005160.3,HGNC:HGNC:290,MIM:109636 G protein-coupled receptor kinase 3 GO:0004672,GO:0004703,GO:0005524,GO:0005829,GO:0005886,GO:0007165,GO:0007186,GO:0031623,GO:0047696 protein kinase activity|G-protein coupled receptor kinase activity|ATP binding|cytosol|plasma membrane|signal transduction|G-protein coupled receptor signaling pathway|receptor internalization|beta-adrenergic receptor kinase activity hsa04062,hsa04144,hsa04340,hsa04724,hsa04740,hsa05032 Chemokine signaling pathway|Endocytosis|Hedgehog signaling pathway|Glutamatergic synapse|Olfactory transduction|Morphine addiction GRK4 35.2783997590919 38.0902821828726 32.4665173353113 0.852356965470578 -0.230470339952429 0.658285510859228 1 0.290639 0.211967 0.113318 0.229568 GeneID:2868,Genbank:XM_011513447.2,HGNC:HGNC:4543,MIM:137026 G protein-coupled receptor kinase 4 GO:0002031,GO:0004703,GO:0005524,GO:0005829,GO:0005938,GO:0007165,GO:0008277,GO:0022400,GO:0030425,GO:0031623,GO:0043025,GO:0050254,GO:0097381 G-protein coupled receptor internalization|G-protein coupled receptor kinase activity|ATP binding|cytosol|cell cortex|signal transduction|regulation of G-protein coupled receptor protein signaling pathway|regulation of rhodopsin mediated signaling pathway|dendrite|receptor internalization|neuronal cell body|rhodopsin kinase activity|photoreceptor disc membrane hsa04062,hsa04144,hsa05032 Chemokine signaling pathway|Endocytosis|Morphine addiction GRK5 372.09832046467 379.269928489438 364.926712439902 0.962182037192712 -0.0556182286358969 0.76847606747217 1 4.64864 4.94059 4.67406 4.50793 GeneID:2869,Genbank:NM_005308.2,HGNC:HGNC:4544,MIM:600870 G protein-coupled receptor kinase 5 GO:0004674,GO:0004703,GO:0005080,GO:0005524,GO:0005543,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0007186,GO:0007188,GO:0007217,GO:0008277,GO:0008284,GO:0016055,GO:0016607,GO:0031965,GO:0043066,GO:0045444,GO:0046777,GO:0047696,GO:0051726 protein serine/threonine kinase activity|G-protein coupled receptor kinase activity|protein kinase C binding|ATP binding|phospholipid binding|cytoplasm|cytosol|plasma membrane|apoptotic process|G-protein coupled receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|tachykinin receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation|Wnt signaling pathway|nuclear speck|nuclear membrane|negative regulation of apoptotic process|fat cell differentiation|protein autophosphorylation|beta-adrenergic receptor kinase activity|regulation of cell cycle hsa04062,hsa04144,hsa05032 Chemokine signaling pathway|Endocytosis|Morphine addiction GRK6 1864.86878878431 1876.57633258208 1853.16124498654 0.98752244329794 -0.0181145583895494 0.869441504827377 1 15.036 15.9778 15.5395 15.861 GeneID:2870,Genbank:XM_006714859.2,HGNC:HGNC:4545,MIM:600869 G protein-coupled receptor kinase 6 GO:0004703,GO:0005524,GO:0005886,GO:0007186,GO:0008277,GO:0016020,GO:0016055,GO:0047696 G-protein coupled receptor kinase activity|ATP binding|plasma membrane|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|membrane|Wnt signaling pathway|beta-adrenergic receptor kinase activity hsa04062,hsa04144,hsa05032 Chemokine signaling pathway|Endocytosis|Morphine addiction GRK7 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00752655 0 0 0 GeneID:131890,Genbank:XM_017005717.2,HGNC:HGNC:17031,MIM:606987 G protein-coupled receptor kinase 7 GO:0004703,GO:0005524,GO:0007165,GO:0007601,GO:0022400,GO:0046777,GO:0050254,GO:0097381 G-protein coupled receptor kinase activity|ATP binding|signal transduction|visual perception|regulation of rhodopsin mediated signaling pathway|protein autophosphorylation|rhodopsin kinase activity|photoreceptor disc membrane hsa04062,hsa04144,hsa04744 Chemokine signaling pathway|Endocytosis|Phototransduction GRM1 7.2480010669445 5.28492421705316 9.21107791683585 1.74289687770999 0.801487211794298 0.470324583541723 1 0.048422 0.0110915 0.0688179 0.0320002 GeneID:2911,Genbank:XM_017010784.1,HGNC:HGNC:4593,MIM:604473 glutamate metabotropic receptor 1 GO:0000186,GO:0000187,GO:0004930,GO:0005634,GO:0005886,GO:0005887,GO:0007186,GO:0007196,GO:0007216,GO:0007268,GO:0007626,GO:0008066,GO:0014069,GO:0019233,GO:0030425,GO:0038037,GO:0038038,GO:0038042,GO:0042734,GO:0042802,GO:0051482,GO:0051930,GO:0051966,GO:0071257,GO:0099583 activation of MAPKK activity|activation of MAPK activity|G-protein coupled receptor activity|nucleus|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway|G-protein coupled glutamate receptor signaling pathway|chemical synaptic transmission|locomotory behavior|glutamate receptor activity|postsynaptic density|sensory perception of pain|dendrite|G-protein coupled receptor dimeric complex|G-protein coupled receptor homodimeric complex|dimeric G-protein coupled receptor signaling pathway|presynaptic membrane|identical protein binding|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|regulation of sensory perception of pain|regulation of synaptic transmission, glutamatergic|cellular response to electrical stimulus|neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration hsa04020,hsa04068,hsa04072,hsa04080,hsa04540,hsa04720,hsa04723,hsa04724,hsa04730,hsa04742,hsa04915 Calcium signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Gap junction|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Long-term depression|Taste transduction|Estrogen signaling pathway GRM2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00764968 0 GeneID:2912,Genbank:NM_001349117.1,HGNC:HGNC:4594,MIM:604099 glutamate metabotropic receptor 2 GO:0001641,GO:0004930,GO:0005246,GO:0005622,GO:0005886,GO:0005887,GO:0007186,GO:0007194,GO:0007216,GO:0007268,GO:0008066,GO:0014047,GO:0030054,GO:0030424,GO:0030425,GO:0042734,GO:0051966 group II metabotropic glutamate receptor activity|G-protein coupled receptor activity|calcium channel regulator activity|intracellular|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|G-protein coupled glutamate receptor signaling pathway|chemical synaptic transmission|glutamate receptor activity|glutamate secretion|cell junction|axon|dendrite|presynaptic membrane|regulation of synaptic transmission, glutamatergic hsa04072,hsa04080,hsa04724,hsa05030 Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Glutamatergic synapse|Cocaine addiction GRM3 1.21517230615302 0.490071401957362 1.94027321034868 3.95916432299286 1.98519594689495 0.683429885754535 1 0 0.00662842 0.0272384 0 GeneID:2913,Genbank:NM_000840.2,HGNC:HGNC:4595,MIM:601115 glutamate metabotropic receptor 3 GO:0001641,GO:0004930,GO:0005246,GO:0005886,GO:0005887,GO:0007186,GO:0007194,GO:0007216,GO:0007268,GO:0008066,GO:0014069,GO:0030424,GO:0042734,GO:0043197,GO:0045211,GO:0051966 group II metabotropic glutamate receptor activity|G-protein coupled receptor activity|calcium channel regulator activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|G-protein coupled glutamate receptor signaling pathway|chemical synaptic transmission|glutamate receptor activity|postsynaptic density|axon|presynaptic membrane|dendritic spine|postsynaptic membrane|regulation of synaptic transmission, glutamatergic hsa04072,hsa04080,hsa04724,hsa05030 Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Glutamatergic synapse|Cocaine addiction GRM5 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0048924 GeneID:2915,Genbank:XM_017017627.2,HGNC:HGNC:4597,MIM:604102 glutamate metabotropic receptor 5 GO:0001932,GO:0004930,GO:0005737,GO:0005886,GO:0005887,GO:0006417,GO:0006448,GO:0007186,GO:0007196,GO:0007206,GO:0007216,GO:0007268,GO:0007611,GO:0007612,GO:0007626,GO:0008066,GO:0014069,GO:0030296,GO:0035584,GO:0042734,GO:0043005,GO:0048169,GO:0050808,GO:0050890,GO:0051966,GO:0061098,GO:0070062,GO:0090647,GO:0099530,GO:0099583,GO:1902938,GO:1904646,GO:1990782 regulation of protein phosphorylation|G-protein coupled receptor activity|cytoplasm|plasma membrane|integral component of plasma membrane|regulation of translation|regulation of translational elongation|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway|phospholipase C-activating G-protein coupled glutamate receptor signaling pathway|G-protein coupled glutamate receptor signaling pathway|chemical synaptic transmission|learning or memory|learning|locomotory behavior|glutamate receptor activity|postsynaptic density|protein tyrosine kinase activator activity|calcium-mediated signaling using intracellular calcium source|presynaptic membrane|neuron projection|regulation of long-term neuronal synaptic plasticity|synapse organization|cognition|regulation of synaptic transmission, glutamatergic|positive regulation of protein tyrosine kinase activity|extracellular exosome|modulation of age-related behavioral decline|G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential|neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration|regulation of intracellular calcium activated chloride channel activity|cellular response to amyloid-beta|protein tyrosine kinase binding hsa04020,hsa04072,hsa04080,hsa04540,hsa04720,hsa04723,hsa04724,hsa05016 Calcium signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Gap junction|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Huntington disease GRM7 6.98808845531034 6.7071121482403 7.26906476238037 1.08378458593204 0.116078033729897 0.983898806045844 1 0.0233255 0.0190937 0.0160318 0.0208655 GeneID:2917,Genbank:NM_181874.2,HGNC:HGNC:4599,MIM:604101 glutamate metabotropic receptor 7 GO:0001642,GO:0005246,GO:0005509,GO:0005886,GO:0005887,GO:0005938,GO:0007186,GO:0007193,GO:0007196,GO:0007268,GO:0007605,GO:0008066,GO:0010855,GO:0014050,GO:0016021,GO:0016595,GO:0030165,GO:0030424,GO:0030425,GO:0032279,GO:0042734,GO:0043198,GO:0043235,GO:0045211,GO:0048786,GO:0051966,GO:0070905 group III metabotropic glutamate receptor activity|calcium channel regulator activity|calcium ion binding|plasma membrane|integral component of plasma membrane|cell cortex|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway|chemical synaptic transmission|sensory perception of sound|glutamate receptor activity|adenylate cyclase inhibitor activity|negative regulation of glutamate secretion|integral component of membrane|glutamate binding|PDZ domain binding|axon|dendrite|asymmetric synapse|presynaptic membrane|dendritic shaft|receptor complex|postsynaptic membrane|presynaptic active zone|regulation of synaptic transmission, glutamatergic|serine binding hsa04072,hsa04080,hsa04724 Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Glutamatergic synapse GRM8 0.97133319677934 0.490071401957362 1.45259499160132 2.96404765876891 1.56756864484914 0.837512515494886 1 0 0.00532262 0 0.0100661 GeneID:2918,Genbank:XM_011516091.2,HGNC:HGNC:4600,MIM:601116 glutamate metabotropic receptor 8 hsa04072,hsa04080,hsa04724 Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|Glutamatergic synapse GRN 6969.73491045707 6497.27134336433 7442.1984775498 1.14543445767438 0.195894909281254 0.142569383346222 1 105.696 109.063 124.365 127.744 GeneID:2896,Genbank:NM_002087.3,HGNC:HGNC:4601,MIM:138945 granulin precursor GRPEL1 1337.41826983758 1433.25992091454 1241.57661876062 0.866260613754127 -0.207126971081509 0.155085965457371 1 20.4828 22.0968 18.4987 18.8978 GeneID:80273,Genbank:NM_025196.3,HGNC:HGNC:19696,MIM:606173 GrpE like 1, mitochondrial GO:0000774,GO:0001405,GO:0005634,GO:0005739,GO:0005759,GO:0006457,GO:0030150,GO:0042803,GO:0051082,GO:0051087 adenyl-nucleotide exchange factor activity|presequence translocase-associated import motor|nucleus|mitochondrion|mitochondrial matrix|protein folding|protein import into mitochondrial matrix|protein homodimerization activity|unfolded protein binding|chaperone binding GRPEL2 418.112086110154 447.061444092115 389.162728128192 0.870490473448224 -0.200099585620072 0.279802393451982 1 5.22319 5.13153 4.75867 4.34098 GeneID:134266,Genbank:NM_152407.3,HGNC:HGNC:21060 GrpE like 2, mitochondrial GO:0000774,GO:0001405,GO:0005739,GO:0005759,GO:0006457,GO:0030150,GO:0042803,GO:0051082,GO:0051087 adenyl-nucleotide exchange factor activity|presequence translocase-associated import motor|mitochondrion|mitochondrial matrix|protein folding|protein import into mitochondrial matrix|protein homodimerization activity|unfolded protein binding|chaperone binding GRPR 13.7144048736194 14.8266035725598 12.6022061746791 0.849972558651427 -0.234511830268279 0.902511513038546 1 0.375516 0.083847 0.238272 0.174339 GeneID:2925,Genbank:NM_005314.2,HGNC:HGNC:4609,MIM:305670 gastrin releasing peptide receptor GO:0005886,GO:0005887,GO:0007186,GO:0007200,GO:0008188,GO:0008283,GO:0008528,GO:0035176,GO:0036343,GO:0042127,GO:0043207,GO:0061744 plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|neuropeptide receptor activity|cell proliferation|G-protein coupled peptide receptor activity|social behavior|psychomotor behavior|regulation of cell proliferation|response to external biotic stimulus|motor behavior hsa04020,hsa04080 Calcium signaling pathway|Neuroactive ligand-receptor interaction GRSF1 2575.1095428005 2719.22007224886 2430.99901335213 0.89400598287789 -0.161643608624877 0.245555768870235 1 16.7187 16.6142 16.2303 13.6925 GeneID:2926,Genbank:NM_002092.3,HGNC:HGNC:4610,MIM:604851 G-rich RNA sequence binding factor 1 GO:0003723,GO:0003729,GO:0005737,GO:0005739,GO:0006378,GO:0008033,GO:0009952,GO:0016331,GO:0035770,GO:0042645 RNA binding|mRNA binding|cytoplasm|mitochondrion|mRNA polyadenylation|tRNA processing|anterior/posterior pattern specification|morphogenesis of embryonic epithelium|ribonucleoprotein granule|mitochondrial nucleoid GRTP1 104.010722927332 102.374862732694 105.646583121969 1.03195823957115 0.045384590157857 0.882144682952088 1 0.462273 0.428579 0.521445 0.448552 GeneID:79774,Genbank:XM_017020755.2,HGNC:HGNC:20310 growth hormone regulated TBC protein 1 GO:0005096,GO:0005622,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity GRWD1 2620.90893438528 2829.8713648876 2411.94650388295 0.852316657855843 -0.230538566028205 0.0907416281696865 0.97998510908004 50.797 51.2107 43.9955 44.4729 GeneID:83743,Genbank:NM_031485.3,HGNC:HGNC:21270,MIM:610597 glutamate rich WD repeat containing 1 GO:0003682,GO:0003688,GO:0003723,GO:0005634,GO:0005694,GO:0005730,GO:0005829,GO:0006260,GO:0006334,GO:0006337,GO:0042393,GO:0043234 chromatin binding|DNA replication origin binding|RNA binding|nucleus|chromosome|nucleolus|cytosol|DNA replication|nucleosome assembly|nucleosome disassembly|histone binding|protein complex GRXCR2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0179656 GeneID:643226,Genbank:XM_017009708.1,HGNC:HGNC:33862,MIM:615762 glutaredoxin and cysteine rich domain containing 2 GO:0005902,GO:0007605,GO:0032420 microvillus|sensory perception of sound|stereocilium GSAP 176.029370104812 176.604950145718 175.453790063905 0.993481722449666 -0.00943466910721885 0.985517484065962 1 1.23661 1.27912 1.3853 0.956024 GeneID:54103,Genbank:XM_017012348.1,HGNC:HGNC:28042,MIM:613552 gamma-secretase activating protein GO:0001540,GO:0005802,GO:0030162,GO:1902004 amyloid-beta binding|trans-Golgi network|regulation of proteolysis|positive regulation of amyloid-beta formation GSC 34.5325119456424 29.326831877433 39.7381920138519 1.35501141684624 0.438305007267753 0.369205809416832 1 1.62008 1.2227 1.93456 1.95287 GeneID:145258,Genbank:NM_173849.2,HGNC:HGNC:4612,MIM:138890 goosecoid homeobox GO:0000978,GO:0001078,GO:0001085,GO:0001103,GO:0005634,GO:0005667,GO:0007369,GO:0014036,GO:0016604,GO:0021904,GO:0023019,GO:0030178,GO:0030900,GO:0042474,GO:0048644,GO:0048704 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|RNA polymerase II repressing transcription factor binding|nucleus|transcription factor complex|gastrulation|neural crest cell fate specification|nuclear body|dorsal/ventral neural tube patterning|signal transduction involved in regulation of gene expression|negative regulation of Wnt signaling pathway|forebrain development|middle ear morphogenesis|muscle organ morphogenesis|embryonic skeletal system morphogenesis GSDMB 25.4772685903674 30.1148695826079 20.839667598127 0.692005905619541 -0.531143744927573 0.346593103783263 1 0.40874 0.329311 0.316014 0.294378 GeneID:55876,Genbank:NM_001165959.1,HGNC:HGNC:23690,MIM:611221 gasdermin B GSDMC 1.21930543346982 1.47021420587209 0.968396661067546 0.658677257504203 -0.60235635659317 0.974344551264944 1 0 0 0 0.0071685 GeneID:56169,Genbank:XM_011517161.2,HGNC:HGNC:7151,MIM:608384 gasdermin C GO:0005737,GO:0005739,GO:0005815,GO:0005829,GO:0005886,GO:0012501 cytoplasm|mitochondrion|microtubule organizing center|cytosol|plasma membrane|programmed cell death GSDMD 672.241569652439 579.225818140585 765.257321164293 1.32117267082621 0.401819032114755 0.0156792760214066 0.521571941137134 7.58032 8.21055 11.1206 9.9613 GeneID:79792,Genbank:NM_001166237.1,HGNC:HGNC:25697,MIM:617042 gasdermin D GO:0001786,GO:0005546,GO:0005576,GO:0005615,GO:0005654,GO:0005829,GO:0005886,GO:0006954,GO:0019835,GO:0031668,GO:0035580,GO:0035915,GO:0043312,GO:0045087,GO:0046931,GO:0050718,GO:0050829,GO:0050830,GO:0051260,GO:0070269,GO:0070273,GO:0070300,GO:0072559,GO:1901612,GO:1904724,GO:1904813 phosphatidylserine binding|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|extracellular space|nucleoplasm|cytosol|plasma membrane|inflammatory response|cytolysis|cellular response to extracellular stimulus|specific granule lumen|pore formation in membrane of other organism|neutrophil degranulation|innate immune response|pore complex assembly|positive regulation of interleukin-1 beta secretion|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|protein homooligomerization|pyroptosis|phosphatidylinositol-4-phosphate binding|phosphatidic acid binding|NLRP3 inflammasome complex|cardiolipin binding|tertiary granule lumen|ficolin-1-rich granule lumen hsa04621 NOD-like receptor signaling pathway GSDME 727.998509012214 758.607500563777 697.389517460652 0.919302164745762 -0.121388957062521 0.441291151600042 1 9.78272 10.8947 10.057 9.28964 GeneID:1687,Genbank:XM_024446670.1,HGNC:HGNC:2810,MIM:608798 gasdermin E GO:0005546,GO:0005829,GO:0005886,GO:0007605,GO:0008219,GO:0008285,GO:0016020,GO:0043410,GO:0060113,GO:0070265,GO:0070269,GO:0071356,GO:0098586,GO:1901612,GO:2001244 phosphatidylinositol-4,5-bisphosphate binding|cytosol|plasma membrane|sensory perception of sound|cell death|negative regulation of cell proliferation|membrane|positive regulation of MAPK cascade|inner ear receptor cell differentiation|necrotic cell death|pyroptosis|cellular response to tumor necrosis factor|cellular response to virus|cardiolipin binding|positive regulation of intrinsic apoptotic signaling pathway GSE1 1571.42023248277 1591.49311481526 1551.34735015029 0.974774779550562 -0.0368591703423484 0.783224794966112 1 4.5895 4.81669 4.99184 4.48751 GeneID:23199,Genbank:XM_017023084.1,HGNC:HGNC:28979,MIM:616886 Gse1 coiled-coil protein GO:0003964,GO:0046872 RNA-directed DNA polymerase activity|metal ion binding GSG1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0122753 0 0 0 GeneID:83445,Genbank:NM_001206842.1,HGNC:HGNC:19716 germ cell associated 1 GO:0005789,GO:0016021,GO:0070063 endoplasmic reticulum membrane|integral component of membrane|RNA polymerase binding GSK3A 2603.96948824045 2699.58306655441 2508.35590992649 0.929164188723411 -0.105994543137054 0.426000516194717 1 44.2882 46.572 42.5194 43.948 GeneID:2931,Genbank:NM_019884.2,HGNC:HGNC:4616,MIM:606784 glycogen synthase kinase 3 alpha GO:0003073,GO:0003214,GO:0004674,GO:0005102,GO:0005524,GO:0005739,GO:0005829,GO:0005977,GO:0006468,GO:0007212,GO:0007399,GO:0008286,GO:0010628,GO:0010905,GO:0016055,GO:0018107,GO:0030877,GO:0031398,GO:0032007,GO:0032436,GO:0032869,GO:0034236,GO:0036016,GO:0036498,GO:0043025,GO:0043161,GO:0045719,GO:0045732,GO:0045823,GO:0046325,GO:0046627,GO:0050321,GO:0060079,GO:0061052,GO:0071879,GO:0090090,GO:0097191,GO:0097192,GO:0097440,GO:0098794,GO:0106071,GO:1901030,GO:1902004,GO:1903146,GO:1903955,GO:1904227,GO:1990635,GO:2000077,GO:2000466,GO:2000467 regulation of systemic arterial blood pressure|cardiac left ventricle morphogenesis|protein serine/threonine kinase activity|receptor binding|ATP binding|mitochondrion|cytosol|glycogen metabolic process|protein phosphorylation|dopamine receptor signaling pathway|nervous system development|insulin receptor signaling pathway|positive regulation of gene expression|negative regulation of UDP-glucose catabolic process|Wnt signaling pathway|peptidyl-threonine phosphorylation|beta-catenin destruction complex|positive regulation of protein ubiquitination|negative regulation of TOR signaling|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to insulin stimulus|protein kinase A catalytic subunit binding|cellular response to interleukin-3|IRE1-mediated unfolded protein response|neuronal cell body|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of glycogen biosynthetic process|positive regulation of protein catabolic process|positive regulation of heart contraction|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|tau-protein kinase activity|excitatory postsynaptic potential|negative regulation of cell growth involved in cardiac muscle cell development|positive regulation of adrenergic receptor signaling pathway|negative regulation of canonical Wnt signaling pathway|extrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|apical dendrite|postsynapse|positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of amyloid-beta formation|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|negative regulation of glycogen synthase activity, transferring glucose-1-phosphate|proximal dendrite|negative regulation of type B pancreatic cell development|negative regulation of glycogen (starch) synthase activity|positive regulation of glycogen (starch) synthase activity hsa04062,hsa04728,hsa04932 Chemokine signaling pathway|Dopaminergic synapse|Non-alcoholic fatty liver disease (NAFLD) GSK3B 1048.93247707239 1027.75544243686 1070.10951170792 1.04121026026448 0.0582614334890781 0.679794777700033 1 5.75712 5.2771 6.15167 5.20409 GeneID:2932,Genbank:XM_006713610.3,HGNC:HGNC:4617,MIM:605004 glycogen synthase kinase 3 beta hsa01521,hsa04012,hsa04062,hsa04110,hsa04150,hsa04151,hsa04310,hsa04340,hsa04360,hsa04390,hsa04510,hsa04550,hsa04657,hsa04660,hsa04662,hsa04722,hsa04728,hsa04910,hsa04916,hsa04917,hsa04919,hsa04931,hsa04932,hsa04934,hsa05010,hsa05160,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05200,hsa05210,hsa05213,hsa05215,hsa05217,hsa05224,hsa05225,hsa05226 EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Chemokine signaling pathway|Cell cycle|mTOR signaling pathway|PI3K-Akt signaling pathway|Wnt signaling pathway|Hedgehog signaling pathway|Axon guidance|Hippo signaling pathway|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|IL-17 signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Neurotrophin signaling pathway|Dopaminergic synapse|Insulin signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Cushing syndrome|Alzheimer disease|Hepatitis C|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer GSKIP 174.297314214048 190.095609681353 158.499018746743 0.833785793435347 -0.262251304073492 0.444753429264263 1 3.06007 2.35491 2.71969 1.79523 GeneID:51527,Genbank:NM_016472.4,HGNC:HGNC:20343,MIM:616605 GSK3B interacting protein GO:0004860,GO:0005634,GO:0005737,GO:0008631,GO:0034237,GO:0051018,GO:0090263 protein kinase inhibitor activity|nucleus|cytoplasm|intrinsic apoptotic signaling pathway in response to oxidative stress|protein kinase A regulatory subunit binding|protein kinase A binding|positive regulation of canonical Wnt signaling pathway GSN 3179.21316370634 2801.48747519536 3556.93885221731 1.26966080830658 0.344443130435643 0.0268527628293669 0.657435622411498 14.8297 16.5093 18.8918 20.9629 GeneID:2934,Genbank:NM_001353054.1,HGNC:HGNC:4620,MIM:137350 gelsolin hsa04666,hsa04810,hsa05203 Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Viral carcinogenesis GSPT1 3774.85198331309 3882.32924017362 3667.37472645257 0.9446325902768 -0.0821747848703616 0.551637371049603 1 20.7654 20.26 21.1207 17.858 GeneID:2935,Genbank:NM_001130007.1,HGNC:HGNC:4621,MIM:139259 G1 to S phase transition 1 GO:0000184,GO:0002184,GO:0003747,GO:0003924,GO:0005525,GO:0005829,GO:0006479,GO:0018444 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translational termination|translation release factor activity|GTPase activity|GTP binding|cytosol|protein methylation|translation release factor complex hsa03015 mRNA surveillance pathway GSPT2 110.772698062605 107.189332858006 114.356063267203 1.0668604815247 0.0933715203299067 0.785151985416306 1 1.26189 1.62597 1.33735 1.74409 GeneID:23708,Genbank:NM_018094.4,HGNC:HGNC:4622,MIM:300418 G1 to S phase transition 2 GO:0000184,GO:0002184,GO:0003723,GO:0003747,GO:0003924,GO:0005525,GO:0005829,GO:0006415,GO:0007049,GO:0018444 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translational termination|RNA binding|translation release factor activity|GTPase activity|GTP binding|cytosol|translational termination|cell cycle|translation release factor complex hsa03015 mRNA surveillance pathway GSR 3796.29563948461 3922.57496406562 3670.01631490359 0.935614066913774 -0.0960145421814385 0.472217320512922 1 52.5898 54.0603 50.3261 50.7544 GeneID:2936,Genbank:NM_001195104.2,HGNC:HGNC:4623,MIM:138300 glutathione-disulfide reductase hsa00480,hsa04918 Glutathione metabolism|Thyroid hormone synthesis GSS 2042.40393559409 2065.03803192329 2019.76983926488 0.978078760798296 -0.0319774505298969 0.826524964991518 1 21.2115 22.4958 20.105 22.6054 GeneID:2937,Genbank:NM_001322494.1,HGNC:HGNC:4624,MIM:601002 glutathione synthetase hsa00270,hsa00480,hsa04216 Cysteine and methionine metabolism|Glutathione metabolism|Ferroptosis GSTA4 382.551335522221 344.974739007531 420.127932036912 1.21785129324423 0.284337982507985 0.183995768276417 1 8.958 8.15518 9.67338 11.5034 GeneID:2941,Genbank:NM_001512.3,HGNC:HGNC:4629,MIM:605450 glutathione S-transferase alpha 4 hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTCD 453.698265930517 496.413559864899 410.982971996134 0.827904403151245 -0.272463903324422 0.130940612079941 1 4.48798 4.06491 3.82122 3.36325 GeneID:79807,Genbank:XM_011532252.3,HGNC:HGNC:25806,MIM:615912 glutathione S-transferase C-terminal domain containing GO:0005634,GO:0005654,GO:0005737,GO:0070062 nucleus|nucleoplasm|cytoplasm|extracellular exosome GSTK1 3395.22540727156 3171.48324766633 3618.96756687678 1.14109622667555 0.190420456739643 0.16365377833738 1 92.2227 96.6789 103.593 117.838 GeneID:373156,Genbank:NM_001143679.1,HGNC:HGNC:16906,MIM:602321 glutathione S-transferase kappa 1 GO:0004364,GO:0004602,GO:0005102,GO:0005622,GO:0005743,GO:0005759,GO:0005777,GO:0006749,GO:0015035,GO:0016020,GO:0030855,GO:0070062,GO:1901687 glutathione transferase activity|glutathione peroxidase activity|receptor binding|intracellular|mitochondrial inner membrane|mitochondrial matrix|peroxisome|glutathione metabolic process|protein disulfide oxidoreductase activity|membrane|epithelial cell differentiation|extracellular exosome|glutathione derivative biosynthetic process hsa00480,hsa00980,hsa00982,hsa04146,hsa05204 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Peroxisome|Chemical carcinogenesis GSTM1 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0333473 0.0310935 GeneID:2944,Genbank:NM_000561.3,HGNC:HGNC:4632,MIM:138350 glutathione S-transferase mu 1 hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTM2 146.622429207863 142.531291727874 150.713566687853 1.05740686736777 0.0805306014978912 0.766333773900248 1 2.8309 2.99711 3.08577 3.0287 GeneID:2946,Genbank:NM_001142368.1,HGNC:HGNC:4634,MIM:138380 glutathione S-transferase mu 2 GO:0004364,GO:0004602,GO:0005102,GO:0005737,GO:0005829,GO:0006749,GO:0010880,GO:0010881,GO:0014809,GO:0016529,GO:0018916,GO:0019899,GO:0042178,GO:0042803,GO:0043295,GO:0043651,GO:0045171,GO:0055119,GO:0060315,GO:0060316,GO:0070062,GO:0070458,GO:0071313,GO:1901687 glutathione transferase activity|glutathione peroxidase activity|receptor binding|cytoplasm|cytosol|glutathione metabolic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|sarcoplasmic reticulum|nitrobenzene metabolic process|enzyme binding|xenobiotic catabolic process|protein homodimerization activity|glutathione binding|linoleic acid metabolic process|intercellular bridge|relaxation of cardiac muscle|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|extracellular exosome|cellular detoxification of nitrogen compound|cellular response to caffeine|glutathione derivative biosynthetic process hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTM3 1582.15781108562 1558.45743413113 1605.85818804011 1.0304151739219 0.0432257438880453 0.866676904729801 1 11.279 12.7985 11.1651 13.5931 GeneID:2947,Genbank:NM_000849.4,HGNC:HGNC:4635,MIM:138390 glutathione S-transferase mu 3 GO:0004364,GO:0005634,GO:0005737,GO:0005829,GO:0006749,GO:0008065,GO:0018916,GO:0019899,GO:0035686,GO:0042178,GO:0042802,GO:0042803,GO:0043295,GO:0043627,GO:0045171,GO:0070062,GO:0070458,GO:1901687 glutathione transferase activity|nucleus|cytoplasm|cytosol|glutathione metabolic process|establishment of blood-nerve barrier|nitrobenzene metabolic process|enzyme binding|sperm fibrous sheath|xenobiotic catabolic process|identical protein binding|protein homodimerization activity|glutathione binding|response to estrogen|intercellular bridge|extracellular exosome|cellular detoxification of nitrogen compound|glutathione derivative biosynthetic process hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTM4 1118.14339726405 1087.81371081441 1148.4730837137 1.05576264786539 0.0782855304954799 0.620569998200976 1 9.39968 10.3002 9.59727 11.1265 GeneID:2948,Genbank:NM_147148.2,HGNC:HGNC:4636,MIM:138333 glutathione S-transferase mu 4 GO:0004364,GO:0005737,GO:0005829,GO:0006749,GO:0018916,GO:0019899,GO:0042178,GO:0042803,GO:0043295,GO:0045171,GO:1901687 glutathione transferase activity|cytoplasm|cytosol|glutathione metabolic process|nitrobenzene metabolic process|enzyme binding|xenobiotic catabolic process|protein homodimerization activity|glutathione binding|intercellular bridge|glutathione derivative biosynthetic process hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTO1 1915.49353017502 1893.64055375462 1937.34650659542 1.02308038489889 0.0329195041632685 0.873530057630837 1 59.7002 66.4862 59.4802 71.3373 GeneID:9446,Genbank:NM_001191003.1,HGNC:HGNC:13312,MIM:605482 glutathione S-transferase omega 1 GO:0004364,GO:0005737,GO:0005829,GO:0006749,GO:0009407,GO:0010880,GO:0010881,GO:0014810,GO:0016491,GO:0019852,GO:0032259,GO:0035722,GO:0042178,GO:0045174,GO:0050610,GO:0060315,GO:0060316,GO:0070062,GO:0071243,GO:1901687 glutathione transferase activity|cytoplasm|cytosol|glutathione metabolic process|toxin catabolic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|oxidoreductase activity|L-ascorbic acid metabolic process|methylation|interleukin-12-mediated signaling pathway|xenobiotic catabolic process|glutathione dehydrogenase (ascorbate) activity|methylarsonate reductase activity|negative regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|extracellular exosome|cellular response to arsenic-containing substance|glutathione derivative biosynthetic process hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTO2 17.8409764486092 15.3264836296251 20.3554692675932 1.32812390366225 0.409389745224426 0.573141105653946 1 0.0490639 0.0530557 0.057672 0.0504247 GeneID:119391,Genbank:XM_011539270.3,HGNC:HGNC:23064,MIM:612314 glutathione S-transferase omega 2 GO:0004364,GO:0005737,GO:0005829,GO:0006749,GO:0006805,GO:0009407,GO:0016491,GO:0019852,GO:0042802,GO:0045174,GO:0050610,GO:0055114,GO:0070062,GO:0071243,GO:1901687 glutathione transferase activity|cytoplasm|cytosol|glutathione metabolic process|xenobiotic metabolic process|toxin catabolic process|oxidoreductase activity|L-ascorbic acid metabolic process|identical protein binding|glutathione dehydrogenase (ascorbate) activity|methylarsonate reductase activity|oxidation-reduction process|extracellular exosome|cellular response to arsenic-containing substance|glutathione derivative biosynthetic process hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTP1 5309.76574487997 5184.02987265381 5435.50161710612 1.04850893043245 0.0683391493083647 0.764534813954387 1 267.059 287.615 265.181 320.906 GeneID:2950,Genbank:NM_000852.3,HGNC:HGNC:4638,MIM:134660 glutathione S-transferase pi 1 hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05215,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Prostate cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTT2B 48.2122811712506 51.3506190001904 45.0739433423107 0.877768257129356 -0.188087996152671 0.695900204940504 1 1.93691 1.25526 1.55315 1.12388 GeneID:653689,Genbank:XM_005261715.5,HGNC:HGNC:33437 glutathione S-transferase theta 2B (gene/pseudogene) GO:0004364,GO:0005654,GO:0005737,GO:0005829,GO:0006749,GO:0070062,GO:1901687 glutathione transferase activity|nucleoplasm|cytoplasm|cytosol|glutathione metabolic process|extracellular exosome|glutathione derivative biosynthetic process hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis GSTT4 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:25774,Genbank:XM_024452202.1,HGNC:HGNC:26930 glutathione S-transferase theta 4 GO:0004364,GO:0005737,GO:0006749 glutathione transferase activity|cytoplasm|glutathione metabolic process GSTZ1 221.188130214148 197.168331717711 245.207928710584 1.24364763131258 0.314577777615433 0.15226245731179 1 1.57076 1.43937 2.03747 2.20116 GeneID:2954,Genbank:NM_001312660.1,HGNC:HGNC:4643,MIM:603758 glutathione S-transferase zeta 1 hsa00350 Tyrosine metabolism GSX2 25.711609446454 19.4391599440238 31.9840589488843 1.64534162180796 0.718387161418797 0.206639662506884 1 0.717444 0.748479 0.923108 1.06329 GeneID:170825,Genbank:NM_133267.2,HGNC:HGNC:24959,MIM:616253 GS homeobox 2 GO:0002087,GO:0005634,GO:0006351,GO:0006355,GO:0021527,GO:0021575,GO:0021798,GO:0021889,GO:0021978,GO:0030334,GO:0043565,GO:0045747,GO:0048665,GO:0048714,GO:0048853,GO:0060163 regulation of respiratory gaseous exchange by neurological system process|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|spinal cord association neuron differentiation|hindbrain morphogenesis|forebrain dorsal/ventral pattern formation|olfactory bulb interneuron differentiation|telencephalon regionalization|regulation of cell migration|sequence-specific DNA binding|positive regulation of Notch signaling pathway|neuron fate specification|positive regulation of oligodendrocyte differentiation|forebrain morphogenesis|subpallium neuron fate commitment GTDC1 318.649401905531 341.640291743199 295.658512067863 0.86540879168345 -0.208546317721633 0.300224591193479 1 0.738974 0.755232 0.772465 0.550313 GeneID:79712,Genbank:XM_024453144.1,HGNC:HGNC:20887,MIM:610165 glycosyltransferase like domain containing 1 GO:0016757 transferase activity, transferring glycosyl groups GTF2A1 501.787588700873 572.20889703231 431.366280369436 0.753861540089054 -0.407628523343101 0.109063559698745 1 4.69007 3.86579 3.75768 2.73128 GeneID:2957,Genbank:NM_201595.2,HGNC:HGNC:4646,MIM:600520 general transcription factor IIA subunit 1 GO:0001103,GO:0003677,GO:0003713,GO:0005654,GO:0005669,GO:0005672,GO:0005829,GO:0006355,GO:0006366,GO:0006367,GO:0006368,GO:0008134,GO:0017025,GO:0042795,GO:0046982 RNA polymerase II repressing transcription factor binding|DNA binding|transcription coactivator activity|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIA complex|cytosol|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription factor binding|TBP-class protein binding|snRNA transcription from RNA polymerase II promoter|protein heterodimerization activity hsa03022,hsa05203 Basal transcription factors|Viral carcinogenesis GTF2A2 2160.30676500248 2246.56127939709 2074.05225060787 0.923211963826104 -0.115266175019268 0.408184744253251 1 25.9352 26.362 23.8258 26.1455 GeneID:2958,Genbank:NM_001320930.1,HGNC:HGNC:4647,MIM:600519 general transcription factor IIA subunit 2 GO:0001103,GO:0003713,GO:0005654,GO:0005669,GO:0005672,GO:0006366,GO:0006367,GO:0006368,GO:0008134,GO:0016032,GO:0017025,GO:0030054,GO:0042795,GO:0042803,GO:0045944,GO:0046982,GO:0051091,GO:0051123 RNA polymerase II repressing transcription factor binding|transcription coactivator activity|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIA complex|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription factor binding|viral process|TBP-class protein binding|cell junction|snRNA transcription from RNA polymerase II promoter|protein homodimerization activity|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|positive regulation of DNA binding transcription factor activity|RNA polymerase II transcriptional preinitiation complex assembly hsa03022,hsa05203 Basal transcription factors|Viral carcinogenesis GTF2B 538.448636158275 568.068828754297 508.828443562252 0.89571618403715 -0.158886421472624 0.353647240638475 1 10.9766 11.8678 9.77145 10.3837 GeneID:2959,Genbank:NM_001514.5,HGNC:HGNC:4648,MIM:189963 general transcription factor IIB GO:0000979,GO:0005634,GO:0005654,GO:0005669,GO:0006355,GO:0006366,GO:0006367,GO:0006368,GO:0008134,GO:0016032,GO:0016604,GO:0017025,GO:0042795,GO:0046872,GO:0046966,GO:0050434,GO:0051123,GO:0097550,GO:1904798 RNA polymerase II core promoter sequence-specific DNA binding|nucleus|nucleoplasm|transcription factor TFIID complex|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription factor binding|viral process|nuclear body|TBP-class protein binding|snRNA transcription from RNA polymerase II promoter|metal ion binding|thyroid hormone receptor binding|positive regulation of viral transcription|RNA polymerase II transcriptional preinitiation complex assembly|transcriptional preinitiation complex|positive regulation of core promoter binding hsa03022,hsa05203 Basal transcription factors|Viral carcinogenesis GTF2E1 326.520073079394 355.516178477168 297.52396768162 0.836878841790114 -0.256909321575045 0.204843393051021 1 4.04373 4.10709 3.05296 3.74684 GeneID:2960,Genbank:NM_005513.2,HGNC:HGNC:4650,MIM:189962 general transcription factor IIE subunit 1 GO:0005634,GO:0005654,GO:0005669,GO:0005829,GO:0006355,GO:0006366,GO:0006367,GO:0006368,GO:0016032,GO:0042795,GO:0043565,GO:0046872,GO:0097550 nucleus|nucleoplasm|transcription factor TFIID complex|cytosol|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral process|snRNA transcription from RNA polymerase II promoter|sequence-specific DNA binding|metal ion binding|transcriptional preinitiation complex hsa03022,hsa05203 Basal transcription factors|Viral carcinogenesis GTF2E2 1095.02370814777 1106.87846921606 1083.16894707948 0.978579832568816 -0.0312385441343599 0.827140013710417 1 12.4036 12.64 13.7693 11.3969 GeneID:2961,Genbank:NM_002095.5,HGNC:HGNC:4651,MIM:189964 general transcription factor IIE subunit 2 GO:0003677,GO:0003723,GO:0005634,GO:0005654,GO:0005669,GO:0005673,GO:0005829,GO:0006355,GO:0006366,GO:0006367,GO:0006368,GO:0016607,GO:0042795 DNA binding|RNA binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIE complex|cytosol|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|nuclear speck|snRNA transcription from RNA polymerase II promoter hsa03022,hsa05203 Basal transcription factors|Viral carcinogenesis GTF2F1 3728.66540668008 3742.1857468749 3715.14506648526 0.992774094548294 -0.0104626246188494 0.923901988473027 1 38.571 40.781 41.6295 40.3111 GeneID:2962,Genbank:NM_002096.2,HGNC:HGNC:4652,MIM:189968 general transcription factor IIF subunit 1 GO:0000398,GO:0003677,GO:0003713,GO:0003723,GO:0005634,GO:0005654,GO:0005669,GO:0005674,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008134,GO:0008543,GO:0009615,GO:0016070,GO:0019211,GO:0019903,GO:0019904,GO:0030054,GO:0032968,GO:0042795,GO:0043231,GO:0043234,GO:0050434 mRNA splicing, via spliceosome|DNA binding|transcription coactivator activity|RNA binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIF complex|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription factor binding|fibroblast growth factor receptor signaling pathway|response to virus|RNA metabolic process|phosphatase activator activity|protein phosphatase binding|protein domain specific binding|cell junction|positive regulation of transcription elongation from RNA polymerase II promoter|snRNA transcription from RNA polymerase II promoter|intracellular membrane-bounded organelle|protein complex|positive regulation of viral transcription hsa03022 Basal transcription factors GTF2F2 911.653486131911 1023.22912995966 800.077842304161 0.781914645389057 -0.354916964841643 0.0498817381875215 0.815166074133459 10.931 9.47818 7.75303 8.21067 GeneID:2963,Genbank:XM_017020551.1,HGNC:HGNC:4653,MIM:189969 general transcription factor IIF subunit 2 GO:0000398,GO:0000991,GO:0003677,GO:0004386,GO:0005524,GO:0005634,GO:0005654,GO:0005674,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0015630,GO:0016070,GO:0032968,GO:0042795,GO:0050434,GO:0060261,GO:0097550 mRNA splicing, via spliceosome|transcription factor activity, core RNA polymerase II binding|DNA binding|helicase activity|ATP binding|nucleus|nucleoplasm|transcription factor TFIIF complex|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|microtubule cytoskeleton|RNA metabolic process|positive regulation of transcription elongation from RNA polymerase II promoter|snRNA transcription from RNA polymerase II promoter|positive regulation of viral transcription|positive regulation of transcription initiation from RNA polymerase II promoter|transcriptional preinitiation complex hsa03022 Basal transcription factors GTF2H1 984.164549258464 908.440820045472 1059.88827847146 1.16671141926274 0.222447761145128 0.144861059293162 1 8.31556 8.41016 10.1383 9.48607 GeneID:2965,Genbank:NM_001142307.1,HGNC:HGNC:4655,MIM:189972 general transcription factor IIH subunit 1 hsa03022,hsa03420,hsa05203 Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H2 113.708056143701 104.325339685416 123.090772601986 1.17987416070876 0.238632997381565 0.384187380486804 1 1.54406 1.08476 1.42205 1.65187 GeneID:2966,Genbank:NM_001515.3,HGNC:HGNC:4656,MIM:601748 general transcription factor IIH subunit 2 GO:0000438,GO:0000717,GO:0002031,GO:0003676,GO:0003700,GO:0005634,GO:0005654,GO:0005669,GO:0005675,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006357,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006468,GO:0008135,GO:0008270,GO:0009411,GO:0016607,GO:0033683,GO:0047485,GO:0070911 core TFIIH complex portion of holo TFIIH complex|nucleotide-excision repair, DNA duplex unwinding|G-protein coupled receptor internalization|nucleic acid binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor TFIID complex|holo TFIIH complex|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|protein phosphorylation|translation factor activity, RNA binding|zinc ion binding|response to UV|nuclear speck|nucleotide-excision repair, DNA incision|protein N-terminus binding|global genome nucleotide-excision repair hsa03022,hsa03420,hsa05203 Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H2C 197.771340357626 195.852004991002 199.690675724249 1.01959985415224 0.0280030721037288 0.91756204448713 1 3.32079 3.61872 4.38891 2.99703 GeneID:728340,Genbank:XM_005248588.4,HGNC:HGNC:31394 GTF2H2 family member C GO:0000439,GO:0003676,GO:0005675,GO:0006289,GO:0006351,GO:0006357,GO:0008270,GO:0016607 core TFIIH complex|nucleic acid binding|holo TFIIH complex|nucleotide-excision repair|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|zinc ion binding|nuclear speck hsa03022,hsa03420,hsa05203 Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H3 638.678040360155 646.824211643668 630.531869076642 0.974811792332842 -0.0368043913874445 0.8389238306703 1 7.63686 7.54942 7.96193 7.03999 GeneID:2967,Genbank:NM_001516.4,HGNC:HGNC:4657,MIM:601750 general transcription factor IIH subunit 3 hsa03022,hsa03420,hsa05203 Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H4 1103.01369782909 1127.30758061911 1078.71981503907 0.956899282489209 -0.0635610116598979 0.661133741481219 1 25.9464 26.3848 24.6989 26.3657 GeneID:2968,Genbank:NM_001517.4,HGNC:HGNC:4658,MIM:601760 general transcription factor IIH subunit 4 hsa03022,hsa03420,hsa05203 Basal transcription factors|Nucleotide excision repair|Viral carcinogenesis GTF2H5 731.882983012293 725.224810300883 738.541155723702 1.01836167934919 0.0262500371827613 0.870317048939048 1 3.69298 3.7904 3.80596 3.97845 GeneID:404672,Genbank:XM_017010862.1,HGNC:HGNC:21157,MIM:608780 general transcription factor IIH subunit 5 GO:0000182,GO:0000439,GO:0000717,GO:0005654,GO:0005669,GO:0005730,GO:0006283,GO:0006289,GO:0006293,GO:0006294,GO:0006295,GO:0006296,GO:0006355,GO:0006361,GO:0006362,GO:0006363,GO:0006364,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0033683,GO:0070911,GO:0071480 rDNA binding|core TFIIH complex|nucleotide-excision repair, DNA duplex unwinding|nucleoplasm|transcription factor TFIID complex|nucleolus|transcription-coupled nucleotide-excision repair|nucleotide-excision repair|nucleotide-excision repair, preincision complex stabilization|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|rRNA processing|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|nucleotide-excision repair, DNA incision|global genome nucleotide-excision repair|cellular response to gamma radiation hsa03022,hsa03420 Basal transcription factors|Nucleotide excision repair GTF2I 1837.92079926977 1736.25119848715 1939.5904000524 1.11711393014008 0.159776328226118 0.25258778291284 1 9.75028 9.66427 11.9999 10.1634 GeneID:2969,Genbank:NM_032999.3,HGNC:HGNC:4659,MIM:601679 general transcription factor IIi GO:0000981,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006366,GO:0006367,GO:0007165,GO:0014886,GO:0016020,GO:0016525,GO:0042995,GO:0043025,GO:0051019,GO:0051481 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|signal transduction|transition between slow and fast fiber|membrane|negative regulation of angiogenesis|cell projection|neuronal cell body|mitogen-activated protein kinase binding|negative regulation of cytosolic calcium ion concentration hsa03022,hsa04022,hsa05168 Basal transcription factors|cGMP-PKG signaling pathway|Herpes simplex infection GTF2IRD1 1335.5797514288 1313.72376745908 1357.43573539852 1.03327333266108 0.0472219420181559 0.767444835214033 1 8.69736 8.84674 9.35908 8.90675 GeneID:9569,Genbank:NM_001199207.1,HGNC:HGNC:4661,MIM:604318 GTF2I repeat domain containing 1 GO:0000981,GO:0003677,GO:0003700,GO:0003705,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006366,GO:0007275,GO:0014886 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|multicellular organism development|transition between slow and fast fiber hsa03022,hsa04022,hsa05168 Basal transcription factors|cGMP-PKG signaling pathway|Herpes simplex infection GTF2IRD2 142.831627279086 141.743254022699 143.920000535472 1.01535696727002 0.02198702235792 0.941141469818286 1 1.03659 0.918783 0.933822 1.04073 GeneID:84163,Genbank:NM_173537.3,HGNC:HGNC:30775,MIM:608899 GTF2I repeat domain containing 2 GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0006351,GO:0007275 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|transcription, DNA-templated|multicellular organism development GTF2IRD2B 278.213408760066 289.905462545529 266.521354974604 0.919338851480756 -0.12133138435509 0.56005312169127 1 2.54762 2.68445 2.17172 2.56238 GeneID:389524,Genbank:NM_001003795.2,HGNC:HGNC:33125,MIM:608900 GTF2I repeat domain containing 2B GO:0000981,GO:0003677,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0007275 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|multicellular organism development GTF3A 2270.52205284079 2111.24577152877 2429.79833415281 1.15088369479285 0.20274204596045 0.143605020417715 1 56.1162 56.2838 63.5996 67.4814 GeneID:2971,Genbank:NM_002097.2,HGNC:HGNC:4662,MIM:600860 general transcription factor IIIA GO:0003677,GO:0005634,GO:0005654,GO:0006355,GO:0006383,GO:0008097,GO:0009303,GO:0042273,GO:0046872 DNA binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|transcription from RNA polymerase III promoter|5S rRNA binding|rRNA transcription|ribosomal large subunit biogenesis|metal ion binding GTF3C1 3548.38928017539 3477.54043216538 3619.23812818539 1.04074652726087 0.0576187445344551 0.6733958672488 1 14.6326 14.488 16.0407 14.9499 GeneID:2975,Genbank:NM_001286242.1,HGNC:HGNC:4664,MIM:603246 general transcription factor IIIC subunit 1 GO:0000127,GO:0001002,GO:0001003,GO:0001007,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0006383,GO:0006384,GO:0009303,GO:0009304,GO:0016020,GO:0030529,GO:0042791,GO:0042797 transcription factor TFIIIC complex|RNA polymerase III type 1 promoter sequence-specific DNA binding|RNA polymerase III type 2 promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase III transcription factor binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|transcription from RNA polymerase III promoter|transcription initiation from RNA polymerase III promoter|rRNA transcription|tRNA transcription|membrane|intracellular ribonucleoprotein complex|5S class rRNA transcription from RNA polymerase III type 1 promoter|tRNA transcription from RNA polymerase III promoter GTF3C2 2004.35052718573 2145.84975296986 1862.85130140159 0.868118235595667 -0.204036547274233 0.142095770742547 1 15.3342 15.9224 13.7605 13.9529 GeneID:2976,Genbank:NM_001035521.2,HGNC:HGNC:4665,MIM:604883 general transcription factor IIIC subunit 2 GO:0000127,GO:0005654,GO:0006351,GO:0006383,GO:0042791,GO:0042797 transcription factor TFIIIC complex|nucleoplasm|transcription, DNA-templated|transcription from RNA polymerase III promoter|5S class rRNA transcription from RNA polymerase III type 1 promoter|tRNA transcription from RNA polymerase III promoter GTF3C3 504.549841245591 490.522894386303 518.576788104879 1.05719181314396 0.0802371579559681 0.628430667365948 1 3.26976 3.10969 3.86428 3.34713 GeneID:9330,Genbank:NM_012086.4,HGNC:HGNC:4666,MIM:604888 general transcription factor IIIC subunit 3 GO:0000127,GO:0003677,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0006359,GO:0006383,GO:0031965,GO:0042791,GO:0042797 transcription factor TFIIIC complex|DNA binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase III promoter|nuclear membrane|5S class rRNA transcription from RNA polymerase III type 1 promoter|tRNA transcription from RNA polymerase III promoter GTF3C4 1057.58369854742 1102.20807791481 1012.95931918003 0.919027304804717 -0.121820369476246 0.418329344496067 1 5.32676 5.63973 5.69781 4.48255 GeneID:9329,Genbank:NM_012204.3,HGNC:HGNC:4667,MIM:604892 general transcription factor IIIC subunit 4 GO:0000127,GO:0003677,GO:0004402,GO:0005634,GO:0005654,GO:0005739,GO:0006351,GO:0006383,GO:0006384,GO:0008047,GO:0042791,GO:0042797 transcription factor TFIIIC complex|DNA binding|histone acetyltransferase activity|nucleus|nucleoplasm|mitochondrion|transcription, DNA-templated|transcription from RNA polymerase III promoter|transcription initiation from RNA polymerase III promoter|enzyme activator activity|5S class rRNA transcription from RNA polymerase III type 1 promoter|tRNA transcription from RNA polymerase III promoter GTF3C5 1388.77006233438 1352.77559213651 1424.76453253226 1.05321572980339 0.0748009733442001 0.633721168158055 1 16.9154 19.3119 19.2927 19.813 GeneID:9328,Genbank:NM_001122823.1,HGNC:HGNC:4668,MIM:604890 general transcription factor IIIC subunit 5 GO:0000127,GO:0000999,GO:0001009,GO:0003677,GO:0005654,GO:0006351,GO:0006383,GO:0035914,GO:0042791,GO:0042797 transcription factor TFIIIC complex|RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly|transcription from RNA polymerase III type 2 promoter|DNA binding|nucleoplasm|transcription, DNA-templated|transcription from RNA polymerase III promoter|skeletal muscle cell differentiation|5S class rRNA transcription from RNA polymerase III type 1 promoter|tRNA transcription from RNA polymerase III promoter GTF3C6 1013.10517443126 989.175088852033 1037.0352600105 1.04838392282402 0.0681671349332053 0.651763426647149 1 34.6341 30.9414 33.0341 36.4243 GeneID:112495,Genbank:NM_138408.3,HGNC:HGNC:20872,MIM:611784 general transcription factor IIIC subunit 6 GO:0000127,GO:0003677,GO:0005654,GO:0006351,GO:0006383,GO:0016604,GO:0042791,GO:0042797 transcription factor TFIIIC complex|DNA binding|nucleoplasm|transcription, DNA-templated|transcription from RNA polymerase III promoter|nuclear body|5S class rRNA transcription from RNA polymerase III type 1 promoter|tRNA transcription from RNA polymerase III promoter GTPBP1 1115.53177042759 1080.98213715233 1150.08140370286 1.06392267196251 0.0893932966752529 0.56535338586654 1 5.34512 5.45923 6.3618 5.36212 GeneID:9567,Genbank:XM_011530537.2,HGNC:HGNC:4669,MIM:602245 GTP binding protein 1 GO:0000177,GO:0003723,GO:0003924,GO:0005525,GO:0005829,GO:0006955,GO:0007165,GO:0016020,GO:0046039,GO:0061014 cytoplasmic exosome (RNase complex)|RNA binding|GTPase activity|GTP binding|cytosol|immune response|signal transduction|membrane|GTP metabolic process|positive regulation of mRNA catabolic process GTPBP10 316.381754379523 342.438138103482 290.325370655565 0.84781844762814 -0.238172736642405 0.229478112295039 1 1.94726 2.03098 1.96068 1.43289 GeneID:85865,Genbank:NM_033107.3,HGNC:HGNC:25106,MIM:610920 GTP binding protein 10 GO:0003723,GO:0005525,GO:0005694,GO:0005730,GO:0005739,GO:0042254 RNA binding|GTP binding|chromosome|nucleolus|mitochondrion|ribosome biogenesis GTPBP2 2389.38915601182 2197.58559916839 2581.19271285526 1.17455843987694 0.232118496085903 0.098839460616209 1 17.9442 19.5274 23.2316 21.1017 GeneID:54676,Genbank:NM_019096.4,HGNC:HGNC:4670,MIM:607434 GTP binding protein 2 GO:0002576,GO:0003924,GO:0005525,GO:0005576,GO:0031093,GO:0043231 platelet degranulation|GTPase activity|GTP binding|extracellular region|platelet alpha granule lumen|intracellular membrane-bounded organelle GTPBP3 454.918723508858 500.325339426305 409.512107591411 0.818491639981649 -0.288960413702425 0.100684230109238 1 7.34228 7.97269 6.87019 6.17143 GeneID:84705,Genbank:NM_001195422.1,HGNC:HGNC:14880,MIM:608536 GTP binding protein 3, mitochondrial GO:0003924,GO:0005525,GO:0005634,GO:0005739,GO:0006400 GTPase activity|GTP binding|nucleus|mitochondrion|tRNA modification GTPBP4 1418.65765593456 1480.80360455694 1356.51170731217 0.916064563280181 -0.126478813331871 0.399075582867059 1 18.5516 17.6473 17.793 15.9333 GeneID:23560,Genbank:NM_012341.2,HGNC:HGNC:21535 GTP binding protein 4 GO:0000079,GO:0000463,GO:0001649,GO:0003723,GO:0003924,GO:0005525,GO:0005634,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0008156,GO:0008285,GO:0016020,GO:0022408,GO:0030336,GO:0031397,GO:0031965,GO:0033342,GO:0048471,GO:0050821 regulation of cyclin-dependent protein serine/threonine kinase activity|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|osteoblast differentiation|RNA binding|GTPase activity|GTP binding|nucleus|nucleolus|cytoplasm|Golgi apparatus|cytosol|negative regulation of DNA replication|negative regulation of cell proliferation|membrane|negative regulation of cell-cell adhesion|negative regulation of cell migration|negative regulation of protein ubiquitination|nuclear membrane|negative regulation of collagen binding|perinuclear region of cytoplasm|protein stabilization hsa03008 Ribosome biogenesis in eukaryotes GTPBP6 11.7648966647675 11.8959838159236 11.6338095136115 0.977961108020244 -0.0321510022885843 1 1 0.113712 0.0737407 0.131483 0.0861147 GeneID:8225,Genbank:XM_006724447.4,HGNC:HGNC:30189,MIM:300124 GTP binding protein 6 (putative) GO:0005525,GO:0005737,GO:0043022,GO:0046872 GTP binding|cytoplasm|ribosome binding|metal ion binding GTPBP8 180.809927809055 199.762767551553 161.857088066557 0.810246524166653 -0.303567168271478 0.202813894640227 1 6.04466 5.96742 4.4985 4.88913 GeneID:29083,Genbank:NM_014170.2,HGNC:HGNC:25007 GTP binding protein 8 (putative) GO:0005525,GO:0005739,GO:0046872 GTP binding|mitochondrion|metal ion binding GTSE1 2868.11103377984 2804.66600097882 2931.55606658085 1.04524248718305 0.0638376738602097 0.647739959136926 1 16.3309 16.4246 17.8815 16.5352 GeneID:51512,Genbank:XM_005261627.4,HGNC:HGNC:13698,MIM:607477 G2 and S-phase expressed 1 GO:0005654,GO:0005829,GO:0005881,GO:0006977,GO:0007017,GO:0016020,GO:0030335,GO:0043161,GO:0046827,GO:0050821,GO:1900182,GO:1902749,GO:1904527 nucleoplasm|cytosol|cytoplasmic microtubule|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|microtubule-based process|membrane|positive regulation of cell migration|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of protein export from nucleus|protein stabilization|positive regulation of protein localization to nucleus|regulation of cell cycle G2/M phase transition|negative regulation of microtubule binding hsa04115 p53 signaling pathway GUCA1B 49.4373609043278 52.8306418611705 46.0440799474851 0.871541179993246 -0.198359262127379 0.642455090885959 1 0.840681 0.793771 0.773968 0.62756 GeneID:2979,Genbank:NM_002098.5,HGNC:HGNC:4679,MIM:602275 guanylate cyclase activator 1B GO:0001917,GO:0005509,GO:0007168,GO:0007267,GO:0007589,GO:0007601,GO:0007602,GO:0008048,GO:0022400,GO:0097381 photoreceptor inner segment|calcium ion binding|receptor guanylyl cyclase signaling pathway|cell-cell signaling|body fluid secretion|visual perception|phototransduction|calcium sensitive guanylate cyclase activator activity|regulation of rhodopsin mediated signaling pathway|photoreceptor disc membrane hsa04744 Phototransduction GUCD1 1727.75919947786 1579.47368648635 1876.04471246937 1.1877657276094 0.248250310090259 0.0902129229950479 0.979717040875575 14.0796 16.6207 19.7713 17.5479 GeneID:83606,Genbank:NM_001284253.1,HGNC:HGNC:14237 guanylyl cyclase domain containing 1 GUCY1A1 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.00408944 0.00406908 0 GeneID:2982,Genbank:NM_000856.5,HGNC:HGNC:4685,MIM:139396 guanylate cyclase 1 soluble subunit alpha 1 GO:0004383,GO:0004872,GO:0005525,GO:0005886,GO:0006182,GO:0007263,GO:0008015,GO:0008074,GO:0008217,GO:0020037,GO:0030828,GO:0052565,GO:0060087 guanylate cyclase activity|receptor activity|GTP binding|plasma membrane|cGMP biosynthetic process|nitric oxide mediated signal transduction|blood circulation|guanylate cyclase complex, soluble|regulation of blood pressure|heme binding|positive regulation of cGMP biosynthetic process|response to defense-related host nitric oxide production|relaxation of vascular smooth muscle hsa00230,hsa04022,hsa04270,hsa04540,hsa04611,hsa04713,hsa04730,hsa04921,hsa04924,hsa04970 Purine metabolism|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Gap junction|Platelet activation|Circadian entrainment|Long-term depression|Oxytocin signaling pathway|Renin secretion|Salivary secretion GUCY1A2 249.755960083719 254.735991464185 244.775928703254 0.960900449505853 -0.0575411211657827 0.844369339279333 1 0.685538 0.651909 0.78349 0.527016 GeneID:2977,Genbank:NM_000855.2,HGNC:HGNC:4684,MIM:601244 guanylate cyclase 1 soluble subunit alpha 2 GO:0004383,GO:0005525,GO:0005886,GO:0006182,GO:0007165,GO:0008074,GO:0020037,GO:0030828,GO:0035556 guanylate cyclase activity|GTP binding|plasma membrane|cGMP biosynthetic process|signal transduction|guanylate cyclase complex, soluble|heme binding|positive regulation of cGMP biosynthetic process|intracellular signal transduction hsa00230,hsa04022,hsa04270,hsa04540,hsa04611,hsa04713,hsa04730,hsa04921,hsa04924,hsa04970 Purine metabolism|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Gap junction|Platelet activation|Circadian entrainment|Long-term depression|Oxytocin signaling pathway|Renin secretion|Salivary secretion GUCY1B1 214.612855977576 251.853397982233 177.372313972919 0.70426809959273 -0.505803358747744 0.0238692336749758 0.620600075549372 1.97932 1.91687 1.29816 1.27403 GeneID:2983,Genbank:NM_001291953.1,HGNC:HGNC:4687,MIM:139397 guanylate cyclase 1 soluble subunit beta 1 GO:0004383,GO:0004872,GO:0005525,GO:0005886,GO:0006182,GO:0007263,GO:0008015,GO:0008074,GO:0020037,GO:0038060,GO:0046872,GO:0071732 guanylate cyclase activity|receptor activity|GTP binding|plasma membrane|cGMP biosynthetic process|nitric oxide mediated signal transduction|blood circulation|guanylate cyclase complex, soluble|heme binding|nitric oxide-cGMP-mediated signaling pathway|metal ion binding|cellular response to nitric oxide hsa00230,hsa04022,hsa04270,hsa04540,hsa04611,hsa04713,hsa04730,hsa04921,hsa04924,hsa04970 Purine metabolism|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Gap junction|Platelet activation|Circadian entrainment|Long-term depression|Oxytocin signaling pathway|Renin secretion|Salivary secretion GUCY2F 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0107699 0 GeneID:2986,Genbank:NM_001522.2,HGNC:HGNC:4691,MIM:300041 guanylate cyclase 2F, retinal hsa00230,hsa04744 Purine metabolism|Phototransduction GUF1 527.863270468197 548.753113323257 506.973427613137 0.923864330432492 -0.114247087599938 0.678468482554704 1 5.98219 4.75834 5.70421 4.32244 GeneID:60558,Genbank:NM_001345868.1,HGNC:HGNC:25799,MIM:617064 GUF1 homolog, GTPase GO:0003924,GO:0005525,GO:0005743,GO:0006412 GTPase activity|GTP binding|mitochondrial inner membrane|translation GUK1 3854.20397306124 3745.85841206374 3962.54953405874 1.05784818809412 0.0811326009881582 0.61965158816793 1 83.4412 91.417 90.7941 99.8101 GeneID:2987,Genbank:NM_001242839.1,HGNC:HGNC:4693,MIM:139270 guanylate kinase 1 GO:0004385,GO:0005524,GO:0005829,GO:0006163,GO:0006185,GO:0015949,GO:0019673,GO:0034436,GO:0046034,GO:0046054,GO:0046060,GO:0046711 guanylate kinase activity|ATP binding|cytosol|purine nucleotide metabolic process|dGDP biosynthetic process|nucleobase-containing small molecule interconversion|GDP-mannose metabolic process|glycoprotein transport|ATP metabolic process|dGMP metabolic process|dATP metabolic process|GDP biosynthetic process hsa00230 Purine metabolism GULP1 491.914560102235 567.481687802115 416.347432402355 0.733675537645787 -0.446785911547735 0.0355209566958039 0.736921816632118 2.52108 2.15099 2.0171 1.4333 GeneID:51454,Genbank:NM_001252668.1,HGNC:HGNC:18649,MIM:608165 GULP, engulfment adaptor PTB domain containing 1 GO:0004871,GO:0005737,GO:0006869,GO:0006911,GO:0006915 signal transducer activity|cytoplasm|lipid transport|phagocytosis, engulfment|apoptotic process GUSB 2326.70725845356 2227.45932037671 2425.9551965304 1.08911313187085 0.123153822109701 0.382695965511357 1 29.3654 29.6067 32.6241 33.7602 GeneID:2990,Genbank:NM_001293105.1,HGNC:HGNC:4696,MIM:611499 glucuronidase beta GO:0004553,GO:0004566,GO:0005102,GO:0005576,GO:0005615,GO:0005764,GO:0005975,GO:0006027,GO:0016020,GO:0019904,GO:0030214,GO:0035578,GO:0043202,GO:0043231,GO:0043312,GO:0070062,GO:1904813 hydrolase activity, hydrolyzing O-glycosyl compounds|beta-glucuronidase activity|receptor binding|extracellular region|extracellular space|lysosome|carbohydrate metabolic process|glycosaminoglycan catabolic process|membrane|protein domain specific binding|hyaluronan catabolic process|azurophil granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|ficolin-1-rich granule lumen hsa00040,hsa00531,hsa00860,hsa00983,hsa04142 Pentose and glucuronate interconversions|Glycosaminoglycan degradation|Porphyrin and chlorophyll metabolism|Drug metabolism - other enzymes|Lysosome GVQW2 11.2301576036689 6.46698077481559 15.9933344325223 2.47307592049836 1.30630652943478 0.151531087992672 1 0 0.0871852 0.15881 0.0985312 GeneID:100507462,Genbank:NM_001242740.1,HGNC:HGNC:51715 GVQW motif containing 2 GVQW3 61.2282064027674 62.3723212166771 60.0840915888577 0.963313380307424 -0.0539228901021058 0.923165811995778 1 0.147296 0.127424 0.113216 0.154984 GeneID:100506127,Genbank:NM_001347884.1,HGNC:HGNC:51239 GVQW motif containing 3 GXYLT1 157.683343600186 175.30722372837 140.059463472003 0.798937205742409 -0.323845979123483 0.268934771972548 1 1.07667 0.834016 0.801825 0.695147 GeneID:283464,Genbank:NM_001099650.1,HGNC:HGNC:27482,MIM:613321 glucoside xylosyltransferase 1 GO:0016021,GO:0016266,GO:0035252 integral component of membrane|O-glycan processing|UDP-xylosyltransferase activity hsa00514 Other types of O-glycan biosynthesis GXYLT2 323.606364904177 330.705850421829 316.506879386524 0.957064651208337 -0.0633117105864575 0.766642300127297 1 3.97722 4.45362 4.9413 3.46418 GeneID:727936,Genbank:XM_011534068.2,HGNC:HGNC:33383,MIM:613322 glucoside xylosyltransferase 2 GO:0016021,GO:0016266,GO:0035252 integral component of membrane|O-glycan processing|UDP-xylosyltransferase activity hsa00514 Other types of O-glycan biosynthesis GYG1 713.589650779024 689.576093473544 737.603208084504 1.06964730225643 0.0971351712374578 0.56747854792544 1 6.74393 8.05945 8.59771 7.50769 GeneID:2992,Genbank:NM_004130.3,HGNC:HGNC:4699,MIM:603942 glycogenin 1 GO:0005576,GO:0005829,GO:0005978,GO:0005980,GO:0008466,GO:0016020,GO:0034774,GO:0043202,GO:0043312,GO:0046872,GO:0070062,GO:0102751,GO:1904813 extracellular region|cytosol|glycogen biosynthetic process|glycogen catabolic process|glycogenin glucosyltransferase activity|membrane|secretory granule lumen|lysosomal lumen|neutrophil degranulation|metal ion binding|extracellular exosome|UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity|ficolin-1-rich granule lumen hsa00500 Starch and sucrose metabolism GYG2 108.975138664999 121.035793626651 96.9144837033467 0.800709284414582 -0.320649560197232 0.267089181708855 1 1.31561 1.39978 0.916508 1.25082 GeneID:8908,Genbank:XM_017029929.1,HGNC:HGNC:4700,MIM:300198 glycogenin 2 GO:0005829,GO:0005978,GO:0005980,GO:0008466,GO:0043202,GO:0102751 cytosol|glycogen biosynthetic process|glycogen catabolic process|glycogenin glucosyltransferase activity|lysosomal lumen|UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity hsa00500 Starch and sucrose metabolism GYS1 1510.13178710638 1216.52796773896 1803.7356064738 1.48269144179745 0.568218394349947 9.73757109634545e-05 0.0222795626684384 12.0521 12.6769 18.5238 18.9782 GeneID:2997,Genbank:NM_001161587.1,HGNC:HGNC:4706,MIM:138570 glycogen synthase 1 GO:0004373,GO:0005536,GO:0005829,GO:0005978,GO:0007507,GO:0016020,GO:0016234,GO:0019901,GO:0061547 glycogen (starch) synthase activity|glucose binding|cytosol|glycogen biosynthetic process|heart development|membrane|inclusion body|protein kinase binding|glycogen synthase activity, transferring glucose-1-phosphate hsa00500,hsa04151,hsa04152,hsa04910,hsa04922,hsa04931 Starch and sucrose metabolism|PI3K-Akt signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Glucagon signaling pathway|Insulin resistance GYS2 1.80379780716536 2.15239070656922 1.45520490776151 0.676087711826734 -0.564717669077069 0.971494676615895 1 0.0290558 0 0.0140438 0 GeneID:2998,Genbank:XM_024448960.1,HGNC:HGNC:4707,MIM:138571 glycogen synthase 2 GO:0004373,GO:0005737,GO:0005829,GO:0005856,GO:0005938,GO:0005978,GO:0006091,GO:0009749,GO:0030864,GO:0042803,GO:0043265,GO:0061547 glycogen (starch) synthase activity|cytoplasm|cytosol|cytoskeleton|cell cortex|glycogen biosynthetic process|generation of precursor metabolites and energy|response to glucose|cortical actin cytoskeleton|protein homodimerization activity|ectoplasm|glycogen synthase activity, transferring glucose-1-phosphate hsa00500,hsa04151,hsa04152,hsa04910,hsa04922,hsa04931 Starch and sucrose metabolism|PI3K-Akt signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Glucagon signaling pathway|Insulin resistance GZF1 356.965987162795 377.578183219502 336.353791106089 0.890818924541919 -0.166795887847459 0.394765056461939 1 1.91495 1.67948 1.79545 1.49115 GeneID:64412,Genbank:XM_011529321.3,HGNC:HGNC:15808,MIM:613842 GDNF inducible zinc finger protein 1 GO:0000122,GO:0000978,GO:0000980,GO:0001078,GO:0001206,GO:0001658,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0043565,GO:0045892,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding|branching involved in ureteric bud morphogenesis|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding GZMM 1.21093081236113 0 2.42186162472226 Inf Inf 0.339679181581212 1 0 0 0.0693297 0.258457 GeneID:3004,Genbank:NM_005317.3,HGNC:HGNC:4712,MIM:600311 granzyme M GO:0004252,GO:0005576,GO:0006915,GO:0008219,GO:0008236,GO:0016020,GO:0019835,GO:0045087 serine-type endopeptidase activity|extracellular region|apoptotic process|cell death|serine-type peptidase activity|membrane|cytolysis|innate immune response H1F0 2056.22587502575 1941.4754460477 2170.97630400381 1.11820950835268 0.161190517648175 0.341879799076272 1 31.4861 35.3347 35.6076 39.9475 GeneID:3005,Genbank:NM_005318.3,HGNC:HGNC:4714,MIM:142708 H1 histone family member 0 H1FX 2408.595583358 2398.5902922092 2418.60087450679 1.00834264291096 0.0119859614870363 0.978809560989006 1 102.409 112.23 104.162 117.319 GeneID:8971,Genbank:NM_006026.3,HGNC:HGNC:4722,MIM:602785 H1 histone family member X GO:0000786,GO:0003677,GO:0003723,GO:0005634,GO:0005730,GO:0006334,GO:0045296 nucleosome|DNA binding|RNA binding|nucleus|nucleolus|nucleosome assembly|cadherin binding H2AFV 6763.21841949609 7069.65541783429 6456.78142115788 0.913309212337232 -0.130824709397748 0.325234473202029 1 57.0182 57.5114 55.0933 50.3365 GeneID:94239,Genbank:NM_138635.3,HGNC:HGNC:20664 H2A histone family member V GO:0000786,GO:0000790,GO:0003677,GO:0006342,GO:0046982 nucleosome|nuclear chromatin|DNA binding|chromatin silencing|protein heterodimerization activity hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus H2AFX 4258.66675827539 4238.09266903019 4279.24084752058 1.00970912665291 0.0139397464681846 0.943368271136646 1 177.714 181.39 188.739 183.138 GeneID:3014,Genbank:NM_002105.2,HGNC:HGNC:4739,MIM:601772 H2A histone family member X hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus H2AFY 5951.19170567358 5932.38002339264 5970.00338795451 1.00634203547539 0.00912073160197534 0.955446690994865 1 12.8604 13.7202 13.3151 13.2838 GeneID:9555,Genbank:XM_011543730.3,HGNC:HGNC:4740,MIM:610054 H2A histone family member Y GO:0000122,GO:0000182,GO:0000228,GO:0000784,GO:0000785,GO:0000786,GO:0000790,GO:0000793,GO:0000977,GO:0000979,GO:0001046,GO:0001740,GO:0003677,GO:0003682,GO:0005634,GO:0005721,GO:0005730,GO:0006334,GO:0006342,GO:0007549,GO:0010385,GO:0016569,GO:0019216,GO:0019899,GO:0019901,GO:0030291,GO:0031060,GO:0031490,GO:0031492,GO:0033128,GO:0034184,GO:0035098,GO:0040029,GO:0044212,GO:0045618,GO:0045814,GO:0045815,GO:0046982,GO:0051572,GO:0061086,GO:0070062,GO:0071169,GO:0071901,GO:1901837,GO:1902750,GO:1902882,GO:1902883,GO:1902884,GO:1904815 negative regulation of transcription from RNA polymerase II promoter|rDNA binding|nuclear chromosome|nuclear chromosome, telomeric region|chromatin|nucleosome|nuclear chromatin|condensed chromosome|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|core promoter sequence-specific DNA binding|Barr body|DNA binding|chromatin binding|nucleus|pericentric heterochromatin|nucleolus|nucleosome assembly|chromatin silencing|dosage compensation|double-stranded methylated DNA binding|covalent chromatin modification|regulation of lipid metabolic process|enzyme binding|protein kinase binding|protein serine/threonine kinase inhibitor activity|regulation of histone methylation|chromatin DNA binding|nucleosomal DNA binding|negative regulation of histone phosphorylation|positive regulation of maintenance of mitotic sister chromatid cohesion|ESC/E(Z) complex|regulation of gene expression, epigenetic|transcription regulatory region DNA binding|positive regulation of keratinocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|negative regulation of histone H3-K4 methylation|negative regulation of histone H3-K27 methylation|extracellular exosome|establishment of protein localization to chromatin|negative regulation of protein serine/threonine kinase activity|negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|negative regulation of cell cycle G2/M phase transition|regulation of response to oxidative stress|negative regulation of response to oxidative stress|positive regulation of response to oxidative stress|negative regulation of protein localization to chromosome, telomeric region hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus H2AFY2 469.559967526968 422.068819593144 517.051115460793 1.22503983108538 0.292828657942252 0.115476244193282 1 7.07455 7.24154 8.1571 9.50211 GeneID:55506,Genbank:NM_018649.2,HGNC:HGNC:14453,MIM:616141 H2A histone family member Y2 GO:0000122,GO:0000784,GO:0000786,GO:0000790,GO:0000977,GO:0001740,GO:0005654,GO:0006334,GO:0006342,GO:0007420,GO:0007549,GO:0016569,GO:0031490,GO:0044212,GO:0045618,GO:0045814,GO:0046982,GO:0070062,GO:0071169,GO:1901837 negative regulation of transcription from RNA polymerase II promoter|nuclear chromosome, telomeric region|nucleosome|nuclear chromatin|RNA polymerase II regulatory region sequence-specific DNA binding|Barr body|nucleoplasm|nucleosome assembly|chromatin silencing|brain development|dosage compensation|covalent chromatin modification|chromatin DNA binding|transcription regulatory region DNA binding|positive regulation of keratinocyte differentiation|negative regulation of gene expression, epigenetic|protein heterodimerization activity|extracellular exosome|establishment of protein localization to chromatin|negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus H2AFZ 11238.3233742588 11814.6023099988 10662.0444385188 0.902446325213625 -0.148086967486909 0.250960439458612 1 505.697 542.735 428.889 503.8 GeneID:3015,Genbank:NM_002106.3,HGNC:HGNC:4741,MIM:142763 H2A histone family member Z GO:0000786,GO:0000978,GO:0000979,GO:0000980,GO:0005719,GO:0005720,GO:0031492,GO:0045944,GO:0046982,GO:0071392 nucleosome|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|nuclear euchromatin|nuclear heterochromatin|nucleosomal DNA binding|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|cellular response to estradiol stimulus hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus H2BFS 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.274607 0 0 GeneID:54145,Genbank:NM_017445.2,HGNC:HGNC:4762 H2B histone family member S GO:0000786,GO:0002227,GO:0003677,GO:0005615,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0019731,GO:0021762,GO:0046982,GO:0050830,GO:0061844 nucleosome|innate immune response in mucosa|DNA binding|extracellular space|nucleus|nucleoplasm|cytosol|nucleosome assembly|antibacterial humoral response|substantia nigra development|protein heterodimerization activity|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide H3F3A 4419.03150061513 4455.31941725856 4382.74358397171 0.983710296279609 -0.0236945919840869 0.862931940788473 1 240.277 247.027 233.369 250.262 GeneID:3020,Genbank:NM_002107.4,HGNC:HGNC:4764,MIM:601128 H3 histone family member 3A GO:0000228,GO:0000784,GO:0000786,GO:0000788,GO:0000979,GO:0000980,GO:0001649,GO:0005634,GO:0006334,GO:0006336,GO:0006997,GO:0007283,GO:0007286,GO:0007338,GO:0007420,GO:0007566,GO:0008283,GO:0008584,GO:0009725,GO:0030307,GO:0031492,GO:0031508,GO:0031509,GO:0035264,GO:0042393,GO:0042692,GO:0043234,GO:0046982,GO:0048477,GO:0070062,GO:0090230,GO:1902340 nuclear chromosome|nuclear chromosome, telomeric region|nucleosome|nuclear nucleosome|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|osteoblast differentiation|nucleus|nucleosome assembly|DNA replication-independent nucleosome assembly|nucleus organization|spermatogenesis|spermatid development|single fertilization|brain development|embryo implantation|cell proliferation|male gonad development|response to hormone|positive regulation of cell growth|nucleosomal DNA binding|pericentric heterochromatin assembly|telomeric heterochromatin assembly|multicellular organism growth|histone binding|muscle cell differentiation|protein complex|protein heterodimerization activity|oogenesis|extracellular exosome|regulation of centromere complex assembly|negative regulation of chromosome condensation hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3F3B 17598.522702018 18851.8531463724 16345.1922576636 0.867033714444613 -0.205840001421377 0.110174115509767 1 325.705 338.286 291.462 291.424 GeneID:3021,Genbank:NM_005324.4,HGNC:HGNC:4765,MIM:601058 H3 histone family member 3B GO:0000228,GO:0000784,GO:0000786,GO:0000788,GO:0000979,GO:0000980,GO:0001649,GO:0005634,GO:0006334,GO:0006336,GO:0006997,GO:0007283,GO:0007286,GO:0007338,GO:0007420,GO:0007566,GO:0008283,GO:0008584,GO:0009725,GO:0030307,GO:0031492,GO:0031508,GO:0031509,GO:0035264,GO:0042393,GO:0042692,GO:0043234,GO:0046982,GO:0048477,GO:0070062,GO:0090230,GO:1902340 nuclear chromosome|nuclear chromosome, telomeric region|nucleosome|nuclear nucleosome|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|osteoblast differentiation|nucleus|nucleosome assembly|DNA replication-independent nucleosome assembly|nucleus organization|spermatogenesis|spermatid development|single fertilization|brain development|embryo implantation|cell proliferation|male gonad development|response to hormone|positive regulation of cell growth|nucleosomal DNA binding|pericentric heterochromatin assembly|telomeric heterochromatin assembly|multicellular organism growth|histone binding|muscle cell differentiation|protein complex|protein heterodimerization activity|oogenesis|extracellular exosome|regulation of centromere complex assembly|negative regulation of chromosome condensation hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus H3F3C 68.0913440331292 65.9086822348565 70.2740058314019 1.06623290662966 0.0925226130856149 0.825153653354744 1 3.54398 4.16611 4.4764 3.87508 GeneID:440093,Genbank:NM_001013699.2,HGNC:HGNC:33164,MIM:616134 H3 histone family member 3C GO:0000786,GO:0005719,GO:0006334,GO:0030307,GO:0031492,GO:0046982 nucleosome|nuclear euchromatin|nucleosome assembly|positive regulation of cell growth|nucleosomal DNA binding|protein heterodimerization activity hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus H6PD 1318.33710705609 1185.14479770433 1451.52941640784 1.22476968149336 0.292510475262096 0.0493805706839156 0.813062736622003 3.24239 3.59864 4.59485 3.98241 GeneID:9563,Genbank:XM_006711052.4,HGNC:HGNC:4795,MIM:138090 hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase hsa00030 Pentose phosphate pathway HAAO 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00387439 0 GeneID:23498,Genbank:XM_024452774.1,HGNC:HGNC:4796,MIM:604521 3-hydroxyanthranilate 3,4-dioxygenase GO:0000334,GO:0005829,GO:0006569,GO:0008198,GO:0009055,GO:0009435,GO:0010043,GO:0019805,GO:0046686,GO:0070050,GO:0070062 3-hydroxyanthranilate 3,4-dioxygenase activity|cytosol|tryptophan catabolic process|ferrous iron binding|electron transfer activity|NAD biosynthetic process|response to zinc ion|quinolinate biosynthetic process|response to cadmium ion|neuron cellular homeostasis|extracellular exosome hsa00380 Tryptophan metabolism HABP4 484.368843807164 294.114191409297 674.623496205031 2.29374683680668 1.19770616840753 1.93553792043869e-11 6.19991506674923e-08 3.2898 3.36576 8.43351 7.32141 GeneID:22927,Genbank:NM_014282.3,HGNC:HGNC:17062,MIM:617369 hyaluronan binding protein 4 GO:0002576,GO:0003723,GO:0005576,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0006397,GO:0008380,GO:0010494,GO:0015030,GO:0016528,GO:0016607,GO:0030017,GO:0033120,GO:0043392,GO:0045948,GO:0071260,GO:0097504 platelet degranulation|RNA binding|extracellular region|nucleus|nucleolus|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA processing|RNA splicing|cytoplasmic stress granule|Cajal body|sarcoplasm|nuclear speck|sarcomere|positive regulation of RNA splicing|negative regulation of DNA binding|positive regulation of translational initiation|cellular response to mechanical stimulus|Gemini of coiled bodies HACD1 297.589449682286 306.836430549973 288.342468814599 0.939726968853649 -0.089686442243748 0.67139533854307 1 9.79534 9.32875 9.67174 9.16994 GeneID:9200,Genbank:NM_014241.3,HGNC:HGNC:9639,MIM:610467 3-hydroxyacyl-CoA dehydratase 1 GO:0005783,GO:0005789,GO:0007275,GO:0010811,GO:0018812,GO:0019899,GO:0030148,GO:0030176,GO:0030497,GO:0034622,GO:0035338,GO:0042761,GO:0046848,GO:0071529,GO:0080023,GO:0102158,GO:0102343,GO:0102344,GO:0102345 endoplasmic reticulum|endoplasmic reticulum membrane|multicellular organism development|positive regulation of cell-substrate adhesion|3-hydroxyacyl-CoA dehydratase activity|enzyme binding|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation|cellular macromolecular complex assembly|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process|hydroxyapatite binding|cementum mineralization|3R-hydroxyacyl-CoA dehydratase activity|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|3-hydroxy-arachidoyl-CoA dehydratase activity|3-hydroxy-behenoyl-CoA dehydratase activity|3-hydroxy-lignoceroyl-CoA dehydratase activity hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids HACD2 2664.75647489033 2990.48117020809 2339.03177957258 0.782159006006992 -0.35446617039953 0.0356684645310602 0.738653561785664 19.0127 17.033 15.6212 12.197 GeneID:201562,Genbank:NM_001329786.1,HGNC:HGNC:9640,MIM:615939 3-hydroxyacyl-CoA dehydratase 2 GO:0005783,GO:0005789,GO:0016021,GO:0018812,GO:0019899,GO:0030148,GO:0030497,GO:0042761,GO:0102158,GO:0102343,GO:0102344,GO:0102345 endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|3-hydroxyacyl-CoA dehydratase activity|enzyme binding|sphingolipid biosynthetic process|fatty acid elongation|very long-chain fatty acid biosynthetic process|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|3-hydroxy-arachidoyl-CoA dehydratase activity|3-hydroxy-behenoyl-CoA dehydratase activity|3-hydroxy-lignoceroyl-CoA dehydratase activity hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids HACD3 5402.26126467357 5427.16174460016 5377.36078474698 0.990823756100004 -0.0132996356724865 0.920086162474808 1 60.8879 62.8847 62.5259 61.7668 GeneID:51495,Genbank:NM_016395.2,HGNC:HGNC:24175,MIM:615940 3-hydroxyacyl-CoA dehydratase 3 GO:0005096,GO:0005739,GO:0005783,GO:0005829,GO:0005925,GO:0007249,GO:0007257,GO:0007264,GO:0007266,GO:0016601,GO:0018812,GO:0019899,GO:0030148,GO:0030176,GO:0030497,GO:0031965,GO:0042761,GO:0045070,GO:0046726,GO:0102158,GO:0102343,GO:0102344,GO:0102345 GTPase activator activity|mitochondrion|endoplasmic reticulum|cytosol|focal adhesion|I-kappaB kinase/NF-kappaB signaling|activation of JUN kinase activity|small GTPase mediated signal transduction|Rho protein signal transduction|Rac protein signal transduction|3-hydroxyacyl-CoA dehydratase activity|enzyme binding|sphingolipid biosynthetic process|integral component of endoplasmic reticulum membrane|fatty acid elongation|nuclear membrane|very long-chain fatty acid biosynthetic process|positive regulation of viral genome replication|positive regulation by virus of viral protein levels in host cell|very-long-chain 3-hydroxyacyl-CoA dehydratase activity|3-hydroxy-arachidoyl-CoA dehydratase activity|3-hydroxy-behenoyl-CoA dehydratase activity|3-hydroxy-lignoceroyl-CoA dehydratase activity hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids HACE1 194.232119344417 242.090187562663 146.37405112617 0.604626121363479 -0.725884786534554 0.00893322838316547 0.367800991734648 2.09117 1.64171 1.28314 0.917313 GeneID:57531,Genbank:NM_001350555.1,HGNC:HGNC:21033,MIM:610876 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 HACL1 747.142807407385 745.106015372179 749.179599442591 1.00546712009616 0.0078659046668299 0.962154773266421 1 12.8043 13.1703 12.2938 13.6761 GeneID:26061,Genbank:NM_001284413.1,HGNC:HGNC:17856,MIM:604300 2-hydroxyacyl-CoA lyase 1 GO:0000287,GO:0001561,GO:0005102,GO:0005777,GO:0005782,GO:0016830,GO:0030976,GO:0042802,GO:0048037,GO:0051259 magnesium ion binding|fatty acid alpha-oxidation|receptor binding|peroxisome|peroxisomal matrix|carbon-carbon lyase activity|thiamine pyrophosphate binding|identical protein binding|cofactor binding|protein oligomerization hsa04146 Peroxisome HADH 831.265341041864 867.727693064288 794.80298901944 0.915958998856747 -0.126645074589093 0.41764554186442 1 11.7219 11.8836 11.1138 10.7994 GeneID:3033,Genbank:NM_001184705.2,HGNC:HGNC:4799,MIM:601609 hydroxyacyl-CoA dehydrogenase GO:0003857,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005759,GO:0006635,GO:0014823,GO:0032868,GO:0042493,GO:0046676,GO:0070403 3-hydroxyacyl-CoA dehydrogenase activity|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|fatty acid beta-oxidation|response to activity|response to insulin|response to drug|negative regulation of insulin secretion|NAD+ binding hsa00062,hsa00071,hsa00280,hsa00310,hsa00380,hsa00650 Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|Butanoate metabolism HADHA 4316.76266392693 4120.3862376636 4513.13909019027 1.09531942635295 0.131351662166639 0.325341676344377 1 46.3187 46.5472 49.323 52.0461 GeneID:3030,Genbank:NM_000182.4,HGNC:HGNC:4801,MIM:600890 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha GO:0000062,GO:0003857,GO:0003985,GO:0004300,GO:0005739,GO:0005743,GO:0006635,GO:0016507,GO:0016508,GO:0016509,GO:0031012,GO:0032403,GO:0032868,GO:0035965,GO:0042493,GO:0042645,GO:0051287 fatty-acyl-CoA binding|3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|enoyl-CoA hydratase activity|mitochondrion|mitochondrial inner membrane|fatty acid beta-oxidation|mitochondrial fatty acid beta-oxidation multienzyme complex|long-chain-enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|extracellular matrix|protein complex binding|response to insulin|cardiolipin acyl-chain remodeling|response to drug|mitochondrial nucleoid|NAD binding hsa00062,hsa00071,hsa00280,hsa00310,hsa00380,hsa00410,hsa00640,hsa00650 Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation|Lysine degradation|Tryptophan metabolism|beta-Alanine metabolism|Propanoate metabolism|Butanoate metabolism HADHB 1999.97493160845 1951.47573683813 2048.47412637876 1.04970514760168 0.0699841451959738 0.615022670520458 1 28.2729 26.5924 29.7586 30.5255 GeneID:3032,Genbank:NM_001281513.1,HGNC:HGNC:4803,MIM:143450 hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta GO:0003723,GO:0003857,GO:0003988,GO:0004300,GO:0005739,GO:0005740,GO:0005741,GO:0005743,GO:0005783,GO:0006635,GO:0016509,GO:0035965,GO:0042645,GO:0070062 RNA binding|3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|mitochondrion|mitochondrial envelope|mitochondrial outer membrane|mitochondrial inner membrane|endoplasmic reticulum|fatty acid beta-oxidation|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|cardiolipin acyl-chain remodeling|mitochondrial nucleoid|extracellular exosome hsa00062,hsa00071,hsa00280 Fatty acid elongation|Fatty acid degradation|Valine, leucine and isoleucine degradation HAGH 1218.88091748437 1229.73148662734 1208.0303483414 0.98235294572683 -0.0256866369809383 0.899327791109517 1 21.88 24.091 19.5122 25.1818 GeneID:3029,Genbank:NM_001286249.1,HGNC:HGNC:4805,MIM:138760 hydroxyacylglutathione hydrolase GO:0004416,GO:0005737,GO:0005759,GO:0005829,GO:0006090,GO:0006750,GO:0019243,GO:0046872,GO:0070062 hydroxyacylglutathione hydrolase activity|cytoplasm|mitochondrial matrix|cytosol|pyruvate metabolic process|glutathione biosynthetic process|methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione|metal ion binding|extracellular exosome hsa00620 Pyruvate metabolism HAGHL 240.13493214807 229.253295563257 251.016568732882 1.09493112461548 0.130840121606474 0.558056180710473 1 4.95352 4.59839 4.86376 6.19899 GeneID:84264,Genbank:NM_001323635.1,HGNC:HGNC:14177 hydroxyacylglutathione hydrolase like GO:0004416,GO:0019243,GO:0046872 hydroxyacylglutathione hydrolase activity|methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione|metal ion binding HAL 2.53553338836291 3.13253351048394 1.93853326624189 0.61883879605885 -0.692364450254232 0.833281817632912 1 0.0101271 0.0187532 0.00958947 0.0178291 GeneID:3034,Genbank:NM_001258333.1,HGNC:HGNC:4806,MIM:609457 histidine ammonia-lyase GO:0004397,GO:0005829,GO:0006548,GO:0019556,GO:0019557 histidine ammonia-lyase activity|cytosol|histidine catabolic process|histidine catabolic process to glutamate and formamide|histidine catabolic process to glutamate and formate hsa00340 Histidine metabolism HAP1 94.0356027048063 87.7403642588742 100.330841150738 1.14349697540253 0.193452549765722 0.535850885386416 1 0.802832 0.781692 1.04813 0.771139 GeneID:9001,Genbank:NM_001079871.1,HGNC:HGNC:4812,MIM:600947 huntingtin associated protein 1 GO:0005634,GO:0005739,GO:0005764,GO:0005776,GO:0005783,GO:0005813,GO:0005814,GO:0005856,GO:0006887,GO:0006914,GO:0007268,GO:0007420,GO:0008021,GO:0008089,GO:0008090,GO:0008104,GO:0015031,GO:0015629,GO:0016234,GO:0017157,GO:0021549,GO:0021979,GO:0030030,GO:0030054,GO:0031587,GO:0032230,GO:0032901,GO:0044325,GO:0045742,GO:0047496,GO:0048011,GO:0048403,GO:0050769,GO:1902430,GO:1902513,GO:1902857,GO:1904115 nucleus|mitochondrion|lysosome|autophagosome|endoplasmic reticulum|centrosome|centriole|cytoskeleton|exocytosis|autophagy|chemical synaptic transmission|brain development|synaptic vesicle|anterograde axonal transport|retrograde axonal transport|protein localization|protein transport|actin cytoskeleton|inclusion body|regulation of exocytosis|cerebellum development|hypothalamus cell differentiation|cell projection organization|cell junction|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|positive regulation of synaptic transmission, GABAergic|positive regulation of neurotrophin production|ion channel binding|positive regulation of epidermal growth factor receptor signaling pathway|vesicle transport along microtubule|neurotrophin TRK receptor signaling pathway|brain-derived neurotrophic factor binding|positive regulation of neurogenesis|negative regulation of amyloid-beta formation|regulation of organelle transport along microtubule|positive regulation of non-motile cilium assembly|axon cytoplasm hsa04727,hsa05016 GABAergic synapse|Huntington disease HAPLN2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0134447 0 0 GeneID:60484,Genbank:XM_017002020.1,HGNC:HGNC:17410 hyaluronan and proteoglycan link protein 2 GO:0001501,GO:0005201,GO:0005540,GO:0005578,GO:0007155,GO:0007417,GO:0008065,GO:0085029 skeletal system development|extracellular matrix structural constituent|hyaluronic acid binding|proteinaceous extracellular matrix|cell adhesion|central nervous system development|establishment of blood-nerve barrier|extracellular matrix assembly HAPLN3 219.511961545575 237.420813262261 201.603109828889 0.84913831714574 -0.235928519663911 0.286570581351844 1 4.87138 4.39162 3.82816 3.77026 GeneID:145864,Genbank:NM_178232.3,HGNC:HGNC:21446 hyaluronan and proteoglycan link protein 3 GO:0001501,GO:0005201,GO:0005540,GO:0005578,GO:0005615,GO:0007155,GO:0007417 skeletal system development|extracellular matrix structural constituent|hyaluronic acid binding|proteinaceous extracellular matrix|extracellular space|cell adhesion|central nervous system development HAPLN4 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0124236 GeneID:404037,Genbank:NM_023002.2,HGNC:HGNC:31357 hyaluronan and proteoglycan link protein 4 GO:0001501,GO:0005201,GO:0005540,GO:0005578,GO:0007155,GO:0007417 skeletal system development|extracellular matrix structural constituent|hyaluronic acid binding|proteinaceous extracellular matrix|cell adhesion|central nervous system development HARBI1 167.272470130879 166.381094289514 168.163845972243 1.01071486932059 0.0153760589271649 0.9729270177516 1 1.68277 1.98791 2.10047 1.79576 GeneID:283254,Genbank:XM_017017606.2,HGNC:HGNC:26522,MIM:615086 harbinger transposase derived 1 GO:0004518,GO:0005634,GO:0005815,GO:0005829,GO:0005886,GO:0046872 nuclease activity|nucleus|microtubule organizing center|cytosol|plasma membrane|metal ion binding HARS 3099.76224600822 3004.58367301039 3194.94081900605 1.06335558157544 0.0886241086226973 0.527247748796751 1 42.3646 44.9346 44.46 49.9705 GeneID:3035,Genbank:NM_001289094.1,HGNC:HGNC:4816,MIM:142810 histidyl-tRNA synthetase GO:0004821,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006412,GO:0006418,GO:0006427,GO:0032543,GO:0042802 histidine-tRNA ligase activity|ATP binding|cytoplasm|mitochondrion|cytosol|translation|tRNA aminoacylation for protein translation|histidyl-tRNA aminoacylation|mitochondrial translation|identical protein binding hsa00970 Aminoacyl-tRNA biosynthesis HARS2 1131.46251338013 1139.58675763166 1123.33826912861 0.98574177139719 -0.0207183325814237 0.898928251101819 1 11.8614 11.6894 11.9546 12.0311 GeneID:23438,Genbank:NM_001278732.1,HGNC:HGNC:4817,MIM:600783 histidyl-tRNA synthetase 2, mitochondrial GO:0003723,GO:0004821,GO:0005524,GO:0005739,GO:0005759,GO:0006412,GO:0006418,GO:0006427,GO:0042803 RNA binding|histidine-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|translation|tRNA aminoacylation for protein translation|histidyl-tRNA aminoacylation|protein homodimerization activity hsa00970 Aminoacyl-tRNA biosynthesis HAS2 47.4236598748631 33.7756921146262 61.0716276351 1.80815325494555 0.854516962476382 0.0365771713847977 0.739899327172153 0.474721 0.288433 0.865775 0.584309 GeneID:3037,Genbank:NM_005328.2,HGNC:HGNC:4819,MIM:601636 hyaluronan synthase 2 HAS3 202.656722124993 179.017089535928 226.296354714058 1.26410475838197 0.338116026913448 0.152423133796516 1 1.22992 1.49624 1.71343 1.95698 GeneID:3038,Genbank:NM_001199280.1,HGNC:HGNC:4820,MIM:602428 hyaluronan synthase 3 GO:0005737,GO:0005886,GO:0005887,GO:0005975,GO:0007155,GO:0016021,GO:0030213,GO:0036117,GO:0045226,GO:0045893,GO:0050501,GO:0085029,GO:1900106 cytoplasm|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|cell adhesion|integral component of membrane|hyaluronan biosynthetic process|hyaluranon cable|extracellular polysaccharide biosynthetic process|positive regulation of transcription, DNA-templated|hyaluronan synthase activity|extracellular matrix assembly|positive regulation of hyaluranon cable assembly HASPIN 618.159948145867 617.920824584146 618.399071707589 1.00077396181584 0.00111615899702717 1 1 8.07179 8.54237 8.94023 8.16632 GeneID:83903,Genbank:NM_031965.2,HGNC:HGNC:19682,MIM:609240 histone H3 associated protein kinase GO:0004672,GO:0005524,GO:0005634,GO:0005694,GO:0005737,GO:0005813,GO:0005819,GO:0006468,GO:0007064,GO:0035556,GO:0071459,GO:0072354,GO:2000751 protein kinase activity|ATP binding|nucleus|chromosome|cytoplasm|centrosome|spindle|protein phosphorylation|mitotic sister chromatid cohesion|intracellular signal transduction|protein localization to chromosome, centromeric region|histone kinase activity (H3-T3 specific)|histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore HAT1 1039.23953912661 1070.92771808209 1007.55136017114 0.940821068648362 -0.0880077267898612 0.687353750553 1 12.1638 9.80077 10.6713 9.87886 GeneID:8520,Genbank:XM_006712808.3,HGNC:HGNC:4821,MIM:603053 histone acetyltransferase 1 hsa05034 Alcoholism HAUS1 223.871693602777 237.90107600911 209.842311196444 0.882057007545472 -0.181056194381949 0.419717992366196 1 7.4349 7.19973 6.78785 6.59026 GeneID:115106,Genbank:NM_138443.3,HGNC:HGNC:25174,MIM:608775 HAUS augmin like complex subunit 1 GO:0000086,GO:0000922,GO:0005813,GO:0005829,GO:0005874,GO:0007098,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711 G2/M transition of mitotic cell cycle|spindle pole|centrosome|cytosol|microtubule|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking HAUS2 1220.54942312324 1340.96381821314 1100.13502803334 0.820406198206967 -0.28558970340032 0.0553345514920082 0.855410907895938 11.434 11.6725 10.0386 9.16516 GeneID:55142,Genbank:NM_001323631.1,HGNC:HGNC:25530,MIM:613429 HAUS augmin like complex subunit 2 GO:0005737,GO:0005813,GO:0005819,GO:0005874,GO:0007098,GO:0051225,GO:0051301,GO:0070652 cytoplasm|centrosome|spindle|microtubule|centrosome cycle|spindle assembly|cell division|HAUS complex HAUS3 138.740144007325 129.165093706078 148.315194308572 1.14826064885665 0.19945016303323 0.453871592040624 1 2.12783 2.3648 3.10649 2.31802 GeneID:79441,Genbank:NM_024511.6,HGNC:HGNC:28719,MIM:613430 HAUS augmin like complex subunit 3 GO:0000086,GO:0005654,GO:0005739,GO:0005813,GO:0005819,GO:0005829,GO:0005874,GO:0007098,GO:0010389,GO:0015630,GO:0045171,GO:0051225,GO:0051301,GO:0070652,GO:0072686,GO:0097711 G2/M transition of mitotic cell cycle|nucleoplasm|mitochondrion|centrosome|spindle|cytosol|microtubule|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|intercellular bridge|spindle assembly|cell division|HAUS complex|mitotic spindle|ciliary basal body-plasma membrane docking HAUS4 692.287969220362 657.684251727594 726.89168671313 1.10522896785767 0.144345280542917 0.512829092035576 1 11.5737 14.7105 13.5088 14.5164 GeneID:54930,Genbank:NM_001166270.1,HGNC:HGNC:20163,MIM:613431 HAUS augmin like complex subunit 4 GO:0000086,GO:0005813,GO:0005819,GO:0005829,GO:0005874,GO:0007098,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711 G2/M transition of mitotic cell cycle|centrosome|spindle|cytosol|microtubule|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking HAUS5 774.609801998791 732.173070823403 817.046533174178 1.11591994534206 0.158233533797363 0.333081320255551 1 6.13646 7.04586 7.3409 8.06068 GeneID:23354,Genbank:NM_015302.1,HGNC:HGNC:29130,MIM:613432 HAUS augmin like complex subunit 5 GO:0000086,GO:0005813,GO:0005819,GO:0005829,GO:0005874,GO:0007098,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711 G2/M transition of mitotic cell cycle|centrosome|spindle|cytosol|microtubule|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking HAUS6 455.958642654637 479.567818753862 432.349466555411 0.901539781545088 -0.149536941142625 0.661953223281741 1 2.8755 2.2424 2.6784 1.92815 GeneID:54801,Genbank:NM_001270890.1,HGNC:HGNC:25948,MIM:613433 HAUS augmin like complex subunit 6 GO:0000086,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005874,GO:0007098,GO:0010389,GO:0016607,GO:0051225,GO:0051301,GO:0070652,GO:0097711 G2/M transition of mitotic cell cycle|centrosome|microtubule organizing center|spindle|cytosol|microtubule|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|nuclear speck|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking HAUS7 592.527217864041 593.850507959297 591.203927768785 0.995543356189747 -0.00644394780357304 0.955387849896855 1 14.8221 16.8106 15.5507 16.1607 GeneID:55559,Genbank:NM_017518.7,HGNC:HGNC:32979,MIM:300540 HAUS augmin like complex subunit 7 GO:0000086,GO:0005813,GO:0005819,GO:0005829,GO:0005874,GO:0007098,GO:0010389,GO:0031996,GO:0051225,GO:0051301,GO:0070652,GO:0097711 G2/M transition of mitotic cell cycle|centrosome|spindle|cytosol|microtubule|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|thioesterase binding|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking HAUS8 730.911960134697 745.970488316508 715.853431952887 0.959627013621424 -0.0594543246370891 0.725459737262574 1 15.4831 14.3233 15.857 12.5938 GeneID:93323,Genbank:XM_005260154.5,HGNC:HGNC:30532,MIM:613434 HAUS augmin like complex subunit 8 GO:0000086,GO:0000922,GO:0005813,GO:0005829,GO:0005874,GO:0007098,GO:0010389,GO:0051225,GO:0051301,GO:0070652,GO:0097711 G2/M transition of mitotic cell cycle|spindle pole|centrosome|cytosol|microtubule|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|spindle assembly|cell division|HAUS complex|ciliary basal body-plasma membrane docking HAVCR2 2.21552173964502 2.00831188251439 2.42273159677566 1.20635226922146 0.270651252883868 1 1 0.0173995 0.0484908 0.0330771 0.046263 GeneID:84868,Genbank:NM_032782.4,HGNC:HGNC:18437,MIM:606652 hepatitis A virus cellular receptor 2 GO:0001772,GO:0002250,GO:0002281,GO:0002519,GO:0002652,GO:0002826,GO:0002859,GO:0005769,GO:0006954,GO:0009986,GO:0010629,GO:0016021,GO:0030054,GO:0030886,GO:0032088,GO:0032687,GO:0032689,GO:0032703,GO:0032712,GO:0032715,GO:0032720,GO:0032722,GO:0032729,GO:0032732,GO:0032753,GO:0032815,GO:0034138,GO:0034154,GO:0034162,GO:0042102,GO:0042130,GO:0043032,GO:0045087,GO:0046872,GO:0050830,GO:0060135,GO:0070062,GO:0070374,GO:0071222,GO:0071656,GO:1900425,GO:1900426,GO:1901224,GO:1904469,GO:2000521,GO:2001189 immunological synapse|adaptive immune response|macrophage activation involved in immune response|natural killer cell tolerance induction|regulation of tolerance induction dependent upon immune response|negative regulation of T-helper 1 type immune response|negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|early endosome|inflammatory response|cell surface|negative regulation of gene expression|integral component of membrane|cell junction|negative regulation of myeloid dendritic cell activation|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-alpha production|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of interleukin-3 production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-4 production|negative regulation of natural killer cell activation|toll-like receptor 3 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway|positive regulation of T cell proliferation|negative regulation of T cell proliferation|positive regulation of macrophage activation|innate immune response|metal ion binding|defense response to Gram-positive bacterium|maternal process involved in female pregnancy|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to lipopolysaccharide|negative regulation of granulocyte colony-stimulating factor production|negative regulation of defense response to bacterium|positive regulation of defense response to bacterium|positive regulation of NIK/NF-kappaB signaling|positive regulation of tumor necrosis factor secretion|negative regulation of immunological synapse formation|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell HAX1 2447.35883576644 2358.91209195916 2535.80557957373 1.07498943611233 0.104322482565206 0.600568830219029 1 59.8692 65.815 60.9009 74.3621 GeneID:10456,Genbank:NM_006118.3,HGNC:HGNC:16915,MIM:605998 HCLS1 associated protein X-1 HBE1 1.21343236204623 0.490071401957362 1.93679332213509 3.95206354502522 1.98260614412799 0.683645161929023 1 0 0.0577506 0 0.111019 GeneID:3046,Genbank:NM_005330.3,HGNC:HGNC:4830,MIM:142100 hemoglobin subunit epsilon 1 GO:0005344,GO:0005506,GO:0005829,GO:0005833,GO:0007596,GO:0014070,GO:0019825,GO:0020037,GO:0031721,GO:0051291,GO:0072562 oxygen carrier activity|iron ion binding|cytosol|hemoglobin complex|blood coagulation|response to organic cyclic compound|oxygen binding|heme binding|hemoglobin alpha binding|protein heterooligomerization|blood microparticle HBEGF 264.855824862903 323.258726843099 206.452922882707 0.638661560351051 -0.646876474436729 0.00180896804965584 0.152615325462112 4.90349 5.39367 3.43762 3.20698 GeneID:1839,Genbank:NM_001945.2,HGNC:HGNC:3059,MIM:126150 heparin binding EGF like growth factor hsa01522,hsa04012,hsa04912,hsa04915,hsa04928,hsa05120,hsa05205,hsa05219 Endocrine resistance|ErbB signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Parathyroid hormone synthesis, secretion and action|Epithelial cell signaling in Helicobacter pylori infection|Proteoglycans in cancer|Bladder cancer HBP1 550.538078971028 524.356421430722 576.719736511335 1.0998620650773 0.137322605107471 0.407550904555504 1 5.30623 4.82643 5.95693 5.39726 GeneID:26959,Genbank:NM_001244262.1,HGNC:HGNC:23200,MIM:616714 HMG-box transcription factor 1 HBS1L 1426.77267229077 1459.68250799809 1393.86283658344 0.954908227608398 -0.0665660066983963 0.67111415655341 1 5.69988 5.32355 5.72643 4.79962 GeneID:10767,Genbank:NM_001145158.1,HGNC:HGNC:4834,MIM:612450 HBS1 like translational GTPase GO:0003746,GO:0003924,GO:0005525,GO:0005622,GO:0005829,GO:0006412,GO:0007165,GO:0016020,GO:0043928,GO:0070062 translation elongation factor activity|GTPase activity|GTP binding|intracellular|cytosol|translation|signal transduction|membrane|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|extracellular exosome hsa03015,hsa05134 mRNA surveillance pathway|Legionellosis HBZ 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:3050,Genbank:XM_005255287.3,HGNC:HGNC:4835,MIM:142310 hemoglobin subunit zeta GO:0000122,GO:0005344,GO:0005506,GO:0005833,GO:0019825,GO:0020037,GO:0043249,GO:0070062 negative regulation of transcription from RNA polymerase II promoter|oxygen carrier activity|iron ion binding|hemoglobin complex|oxygen binding|heme binding|erythrocyte maturation|extracellular exosome HCAR2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0222057 0 GeneID:338442,Genbank:NM_177551.3,HGNC:HGNC:24827,MIM:609163 hydroxycarboxylic acid receptor 2 hsa04024 cAMP signaling pathway HCAR3 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0396289 GeneID:8843,Genbank:NM_006018.2,HGNC:HGNC:16824,MIM:606039 hydroxycarboxylic acid receptor 3 hsa04024 cAMP signaling pathway HCCS 804.143474444508 844.502232073552 763.784716815463 0.904420009571912 -0.144935183966841 0.36172901131964 1 6.60115 6.30492 6.17636 5.49328 GeneID:3052,Genbank:NM_005333.4,HGNC:HGNC:4837,MIM:300056 holocytochrome c synthase GO:0004408,GO:0005739,GO:0005743,GO:0009887,GO:0018063,GO:0046872,GO:0055114 holocytochrome-c synthase activity|mitochondrion|mitochondrial inner membrane|animal organ morphogenesis|cytochrome c-heme linkage|metal ion binding|oxidation-reduction process hsa00860 Porphyrin and chlorophyll metabolism HCFC1 4551.00144207702 4650.56974899144 4451.4331351626 0.957180168328403 -0.0631375886823438 0.622373561091558 1 17.2889 17.0278 17.6656 15.9686 GeneID:3054,Genbank:XM_017029471.2,HGNC:HGNC:4839,MIM:300019 host cell factor C1 GO:0000122,GO:0000123,GO:0001205,GO:0003682,GO:0003700,GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006366,GO:0007005,GO:0007049,GO:0010628,GO:0016020,GO:0016579,GO:0019046,GO:0030424,GO:0030425,GO:0033613,GO:0042802,GO:0043025,GO:0043254,GO:0043981,GO:0043982,GO:0043984,GO:0045296,GO:0045787,GO:0048188,GO:0050821,GO:0071339,GO:0071407 negative regulation of transcription from RNA polymerase II promoter|histone acetyltransferase complex|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|chromatin binding|DNA binding transcription factor activity|transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|mitochondrion organization|cell cycle|positive regulation of gene expression|membrane|protein deubiquitination|release from viral latency|axon|dendrite|activating transcription factor binding|identical protein binding|neuronal cell body|regulation of protein complex assembly|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|cadherin binding|positive regulation of cell cycle|Set1C/COMPASS complex|protein stabilization|MLL1 complex|cellular response to organic cyclic compound hsa05168 Herpes simplex infection HCFC1R1 1179.6564368029 1095.89600162001 1263.41687198579 1.15286201438653 0.205219847705067 0.178520403694711 1 28.2844 29.4544 33.286 34.3656 GeneID:54985,Genbank:NM_001288665.1,HGNC:HGNC:21198 host cell factor C1 regulator 1 GO:0005654,GO:0005737 nucleoplasm|cytoplasm HCFC2 119.148955384303 117.115222410992 121.182688357613 1.03473046340933 0.0492550095166929 0.892993241591685 1 0.550904 0.583197 0.655608 0.451116 GeneID:29915,Genbank:NM_013320.2,HGNC:HGNC:24972,MIM:607926 host cell factor C2 GO:0000122,GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0016032 negative regulation of transcription from RNA polymerase II promoter|transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|regulation of transcription from RNA polymerase II promoter|viral process hsa05168 Herpes simplex infection HCK 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0146752 0.015458 0 GeneID:3055,Genbank:NM_001172132.1,HGNC:HGNC:4840,MIM:142370 HCK proto-oncogene, Src family tyrosine kinase GO:0001784,GO:0002522,GO:0002758,GO:0004713,GO:0004715,GO:0005102,GO:0005524,GO:0005654,GO:0005764,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0005901,GO:0005925,GO:0006468,GO:0006954,GO:0007155,GO:0007169,GO:0007229,GO:0007498,GO:0008284,GO:0008360,GO:0018108,GO:0019221,GO:0030133,GO:0030154,GO:0030838,GO:0031234,GO:0031663,GO:0038083,GO:0038096,GO:0042995,GO:0043066,GO:0043299,GO:0045728,GO:0046777,GO:0050690,GO:0050727,GO:0050764,GO:0051090,GO:0060333,GO:0071801,GO:2000251 phosphotyrosine residue binding|leukocyte migration involved in immune response|innate immune response-activating signal transduction|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|receptor binding|ATP binding|nucleoplasm|lysosome|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|caveola|focal adhesion|protein phosphorylation|inflammatory response|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|integrin-mediated signaling pathway|mesoderm development|positive regulation of cell proliferation|regulation of cell shape|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|transport vesicle|cell differentiation|positive regulation of actin filament polymerization|extrinsic component of cytoplasmic side of plasma membrane|lipopolysaccharide-mediated signaling pathway|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|cell projection|negative regulation of apoptotic process|leukocyte degranulation|respiratory burst after phagocytosis|protein autophosphorylation|regulation of defense response to virus by virus|regulation of inflammatory response|regulation of phagocytosis|regulation of DNA binding transcription factor activity|interferon-gamma-mediated signaling pathway|regulation of podosome assembly|positive regulation of actin cytoskeleton reorganization hsa04062,hsa04666,hsa05167 Chemokine signaling pathway|Fc gamma R-mediated phagocytosis|Kaposi sarcoma-associated herpesvirus infection HCLS1 1.78228621950799 2.59443583384164 0.97013660517434 0.373929696976871 -1.41916104230609 0.670772680940795 1 0 0.0307768 0.0319787 0 GeneID:3059,Genbank:NM_001292041.1,HGNC:HGNC:4844,MIM:601306 hematopoietic cell-specific Lyn substrate 1 GO:0000122,GO:0001085,GO:0003779,GO:0005634,GO:0005667,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006355,GO:0008284,GO:0009725,GO:0014068,GO:0017124,GO:0019901,GO:0030041,GO:0030218,GO:0030833,GO:0030854,GO:0032403,GO:0033138,GO:0035556,GO:0042531,GO:0042993,GO:0045651,GO:0045944,GO:0050731,GO:0051897,GO:0071345,GO:2000107,GO:2000251 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor binding|actin binding|nucleus|transcription factor complex|cytoplasm|mitochondrion|cytosol|plasma membrane|regulation of transcription, DNA-templated|positive regulation of cell proliferation|response to hormone|positive regulation of phosphatidylinositol 3-kinase signaling|SH3 domain binding|protein kinase binding|actin filament polymerization|erythrocyte differentiation|regulation of actin filament polymerization|positive regulation of granulocyte differentiation|protein complex binding|positive regulation of peptidyl-serine phosphorylation|intracellular signal transduction|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of transcription factor import into nucleus|positive regulation of macrophage differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling|cellular response to cytokine stimulus|negative regulation of leukocyte apoptotic process|positive regulation of actin cytoskeleton reorganization hsa04530,hsa05100,hsa05130,hsa05131,hsa05205 Tight junction|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Proteoglycans in cancer HCN1 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.00463736 0.00447027 0 0 GeneID:348980,Genbank:NM_021072.3,HGNC:HGNC:4845,MIM:602780 hyperpolarization activated cyclic nucleotide gated potassium channel 1 GO:0005222,GO:0005248,GO:0005249,GO:0005267,GO:0005886,GO:0005887,GO:0022843,GO:0030424,GO:0030425,GO:0030552,GO:0034765,GO:0035725,GO:0042391,GO:0042802,GO:0045176,GO:0046549,GO:0051289,GO:0071320,GO:0071805,GO:0098855 intracellular cAMP activated cation channel activity|voltage-gated sodium channel activity|voltage-gated potassium channel activity|potassium channel activity|plasma membrane|integral component of plasma membrane|voltage-gated cation channel activity|axon|dendrite|cAMP binding|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|identical protein binding|apical protein localization|retinal cone cell development|protein homotetramerization|cellular response to cAMP|potassium ion transmembrane transport|HCN channel complex HCN2 645.734535526071 656.116967971497 635.352103080645 0.968351885556244 -0.0463966968742113 0.772245062954856 1 10.9731 10.5755 11.0065 10.3436 GeneID:610,Genbank:NM_001194.3,HGNC:HGNC:4846,MIM:602781 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 GO:0005222,GO:0005248,GO:0005249,GO:0005886,GO:0005887,GO:0007267,GO:0008076,GO:0030552,GO:0034765,GO:0035725,GO:0042391,GO:0042802,GO:0071320,GO:0071321,GO:0071805,GO:0086012,GO:0098719,GO:0098855,GO:1990573 intracellular cAMP activated cation channel activity|voltage-gated sodium channel activity|voltage-gated potassium channel activity|plasma membrane|integral component of plasma membrane|cell-cell signaling|voltage-gated potassium channel complex|cAMP binding|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|identical protein binding|cellular response to cAMP|cellular response to cGMP|potassium ion transmembrane transport|membrane depolarization during cardiac muscle cell action potential|sodium ion import across plasma membrane|HCN channel complex|potassium ion import across plasma membrane hsa04024 cAMP signaling pathway HCN3 159.396651812839 141.407070099905 177.386233525773 1.25443680715858 0.327039796139499 0.190458482118906 1 1.08228 1.05971 1.62523 1.27409 GeneID:57657,Genbank:NM_020897.2,HGNC:HGNC:19183,MIM:609973 hyperpolarization activated cyclic nucleotide gated potassium channel 3 GO:0005248,GO:0005249,GO:0005886,GO:0005887,GO:0030424,GO:0030425,GO:0030552,GO:0034765,GO:0035725,GO:0042391,GO:0043025,GO:0044316,GO:0071805,GO:0072718,GO:1903351 voltage-gated sodium channel activity|voltage-gated potassium channel activity|plasma membrane|integral component of plasma membrane|axon|dendrite|cAMP binding|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|neuronal cell body|cone cell pedicle|potassium ion transmembrane transport|response to cisplatin|cellular response to dopamine HCN4 1.459773021105 0.980142803914724 1.93940323829528 1.97869456425047 0.984548931915837 0.869473334580252 1 0 0.0118948 0.0126705 0.00592579 GeneID:10021,Genbank:NM_005477.2,HGNC:HGNC:16882,MIM:605206 hyperpolarization activated cyclic nucleotide gated potassium channel 4 GO:0002027,GO:0003254,GO:0005222,GO:0005248,GO:0005249,GO:0005886,GO:0006812,GO:0006936,GO:0008015,GO:0030552,GO:0031226,GO:0034765,GO:0035725,GO:0042391,GO:0042802,GO:0048471,GO:0055117,GO:0071320,GO:0071321,GO:0071805,GO:0086012,GO:0086015,GO:0086041,GO:0086046,GO:0086091,GO:0098719,GO:0098855,GO:0098909,GO:1990573 regulation of heart rate|regulation of membrane depolarization|intracellular cAMP activated cation channel activity|voltage-gated sodium channel activity|voltage-gated potassium channel activity|plasma membrane|cation transport|muscle contraction|blood circulation|cAMP binding|intrinsic component of plasma membrane|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of membrane potential|identical protein binding|perinuclear region of cytoplasm|regulation of cardiac muscle contraction|cellular response to cAMP|cellular response to cGMP|potassium ion transmembrane transport|membrane depolarization during cardiac muscle cell action potential|SA node cell action potential|voltage-gated potassium channel activity involved in SA node cell action potential depolarization|membrane depolarization during SA node cell action potential|regulation of heart rate by cardiac conduction|sodium ion import across plasma membrane|HCN channel complex|regulation of cardiac muscle cell action potential involved in regulation of contraction|potassium ion import across plasma membrane hsa04024,hsa04742 cAMP signaling pathway|Taste transduction HCRT 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:3060,Genbank:NM_001524.1,HGNC:HGNC:4847,MIM:602358 hypocretin neuropeptide precursor hsa04080 Neuroactive ligand-receptor interaction HCRTR1 13.9705445931273 16.7966978354972 11.1443913507573 0.663487041316265 -0.591859806550871 0.448397121683749 1 0 0.0178599 0 0 GeneID:3061,Genbank:NM_001525.2,HGNC:HGNC:4848,MIM:602392 hypocretin receptor 1 GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0007218,GO:0007268,GO:0007631,GO:0016499,GO:0017046,GO:0032870,GO:0042277,GO:0045187,GO:0051480,GO:0070374,GO:1901652 G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|feeding behavior|orexin receptor activity|peptide hormone binding|cellular response to hormone stimulus|peptide binding|regulation of circadian sleep/wake cycle, sleep|regulation of cytosolic calcium ion concentration|positive regulation of ERK1 and ERK2 cascade|response to peptide hsa04080 Neuroactive ligand-receptor interaction HCRTR2 3.96498521467516 3.084507235799 4.84546319355132 1.57090349385942 0.651594553511167 0.737446694533339 1 0.0679937 0.0416821 0.042867 0.0399425 GeneID:3062,Genbank:NM_001526.4,HGNC:HGNC:4849,MIM:602393 hypocretin receptor 2 GO:0005886,GO:0005887,GO:0007186,GO:0007200,GO:0007218,GO:0007268,GO:0007631,GO:0008188,GO:0010840,GO:0016499,GO:0017046,GO:0022410,GO:0032870,GO:0042277,GO:0045187,GO:0051480,GO:1901652 plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|feeding behavior|neuropeptide receptor activity|regulation of circadian sleep/wake cycle, wakefulness|orexin receptor activity|peptide hormone binding|circadian sleep/wake cycle process|cellular response to hormone stimulus|peptide binding|regulation of circadian sleep/wake cycle, sleep|regulation of cytosolic calcium ion concentration|response to peptide hsa04080 Neuroactive ligand-receptor interaction HCST 2.94856227892267 2.98845468642911 2.90866987141623 0.973302317289534 -0.0390401049777162 1 1 0 0 0.0817285 0.0769033 GeneID:10870,Genbank:XM_017026193.1,HGNC:HGNC:16977,MIM:604089 hematopoietic cell signal transducer GO:0005102,GO:0005886,GO:0006468,GO:0009986,GO:0014068,GO:0016021,GO:0043548,GO:0050776 receptor binding|plasma membrane|protein phosphorylation|cell surface|positive regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|phosphatidylinositol 3-kinase binding|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity HDAC1 4777.00817703778 4612.5440593909 4941.47229468465 1.0713116733539 0.0993782599090155 0.457352542572022 1 58.435 58.9289 62.8109 66.6501 GeneID:3065,Genbank:XM_011541309.2,HGNC:HGNC:4852,MIM:601241 histone deacetylase 1 GO:0000118,GO:0000122,GO:0000785,GO:0000790,GO:0000976,GO:0001046,GO:0001047,GO:0001085,GO:0001103,GO:0001106,GO:0001975,GO:0002039,GO:0003682,GO:0003700,GO:0004407,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006325,GO:0006338,GO:0006346,GO:0006351,GO:0006476,GO:0007596,GO:0008134,GO:0008284,GO:0008285,GO:0009913,GO:0010629,GO:0010870,GO:0016032,GO:0016575,GO:0016580,GO:0016581,GO:0019213,GO:0019899,GO:0031000,GO:0032041,GO:0032403,GO:0032496,GO:0032732,GO:0032760,GO:0032922,GO:0033558,GO:0033613,GO:0034599,GO:0042475,GO:0042531,GO:0042733,GO:0042826,GO:0043005,GO:0043044,GO:0043066,GO:0043234,GO:0043524,GO:0043922,GO:0044212,GO:0045652,GO:0045892,GO:0045893,GO:0045944,GO:0046676,GO:0047485,GO:0048471,GO:0048714,GO:0051059,GO:0055093,GO:0060766,GO:0060789,GO:0061029,GO:0061198,GO:0070491,GO:0070932,GO:0070933,GO:0071356,GO:0090090,GO:1901796,GO:1904837,GO:2000343,GO:2000676,GO:2000757 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|chromatin|nuclear chromatin|transcription regulatory region sequence-specific DNA binding|core promoter sequence-specific DNA binding|core promoter binding|RNA polymerase II transcription factor binding|RNA polymerase II repressing transcription factor binding|RNA polymerase II transcription corepressor activity|response to amphetamine|p53 binding|chromatin binding|DNA binding transcription factor activity|histone deacetylase activity|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin organization|chromatin remodeling|methylation-dependent chromatin silencing|transcription, DNA-templated|protein deacetylation|blood coagulation|transcription factor binding|positive regulation of cell proliferation|negative regulation of cell proliferation|epidermal cell differentiation|negative regulation of gene expression|positive regulation of receptor biosynthetic process|viral process|histone deacetylation|Sin3 complex|NuRD complex|deacetylase activity|enzyme binding|response to caffeine|NAD-dependent histone deacetylase activity (H3-K14 specific)|protein complex binding|response to lipopolysaccharide|positive regulation of interleukin-1 production|positive regulation of tumor necrosis factor production|circadian regulation of gene expression|protein deacetylase activity|activating transcription factor binding|cellular response to oxidative stress|odontogenesis of dentin-containing tooth|positive regulation of tyrosine phosphorylation of STAT protein|embryonic digit morphogenesis|histone deacetylase binding|neuron projection|ATP-dependent chromatin remodeling|negative regulation of apoptotic process|protein complex|negative regulation of neuron apoptotic process|negative regulation by host of viral transcription|transcription regulatory region DNA binding|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of insulin secretion|protein N-terminus binding|perinuclear region of cytoplasm|positive regulation of oligodendrocyte differentiation|NF-kappaB binding|response to hyperoxia|negative regulation of androgen receptor signaling pathway|hair follicle placode formation|eyelid development in camera-type eye|fungiform papilla formation|repressing transcription factor binding|histone H3 deacetylation|histone H4 deacetylation|cellular response to tumor necrosis factor|negative regulation of canonical Wnt signaling pathway|regulation of signal transduction by p53 class mediator|beta-catenin-TCF complex assembly|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of type B pancreatic cell apoptotic process|negative regulation of peptidyl-lysine acetylation hsa04110,hsa04213,hsa04330,hsa04919,hsa05016,hsa05031,hsa05034,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05206,hsa05220 Cell cycle|Longevity regulating pathway - multiple species|Notch signaling pathway|Thyroid hormone signaling pathway|Huntington disease|Amphetamine addiction|Alcoholism|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Chronic myeloid leukemia HDAC10 153.971500349869 155.791628545192 152.151372154546 0.976633812582621 -0.0341103676996 0.919514426210905 1 2.19216 1.97446 2.03341 2.48124 GeneID:83933,Genbank:NM_001159286.1,HGNC:HGNC:18128,MIM:608544 histone deacetylase 10 GO:0000118,GO:0000122,GO:0004407,GO:0005634,GO:0005654,GO:0005737,GO:0006325,GO:0006351,GO:0006355,GO:0006476,GO:0014003,GO:0016575,GO:0019899,GO:0032041,GO:0033558,GO:0042826,GO:0045892 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|histone deacetylase activity|nucleus|nucleoplasm|cytoplasm|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|protein deacetylation|oligodendrocyte development|histone deacetylation|enzyme binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|protein deacetylase activity|histone deacetylase binding|negative regulation of transcription, DNA-templated hsa05034,hsa05165,hsa05203 Alcoholism|Human papillomavirus infection|Viral carcinogenesis HDAC11 201.149646882403 195.371742244153 206.927551520654 1.05914780276699 0.0829039296890675 0.738991592776097 1 1.69237 1.80525 1.84489 1.94523 GeneID:79885,Genbank:XM_024453764.1,HGNC:HGNC:19086,MIM:607226 histone deacetylase 11 GO:0000118,GO:0004407,GO:0005634,GO:0005886,GO:0006325,GO:0006351,GO:0006355,GO:0008134,GO:0014003,GO:0016575,GO:0032041,GO:0070062 histone deacetylase complex|histone deacetylase activity|nucleus|plasma membrane|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription factor binding|oligodendrocyte development|histone deacetylation|NAD-dependent histone deacetylase activity (H3-K14 specific)|extracellular exosome hsa05034,hsa05165,hsa05203 Alcoholism|Human papillomavirus infection|Viral carcinogenesis HDAC2 3242.45125172656 3508.22551503908 2976.67698841405 0.848485074763184 -0.237038812555512 0.102091040130886 1 18.123 16.4332 15.9674 13.9072 GeneID:3066,Genbank:NM_001527.3,HGNC:HGNC:4853,MIM:605164 histone deacetylase 2 hsa04110,hsa04213,hsa04330,hsa04919,hsa05016,hsa05034,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05220 Cell cycle|Longevity regulating pathway - multiple species|Notch signaling pathway|Thyroid hormone signaling pathway|Huntington disease|Alcoholism|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Chronic myeloid leukemia HDAC3 2425.56489355694 2331.57293765317 2519.55684946071 1.08062536186269 0.111866446974481 0.422886137487174 1 30.7822 32.0151 34.672 33.3837 GeneID:8841,Genbank:NM_001355040.1,HGNC:HGNC:4854,MIM:605166 histone deacetylase 3 hsa04919,hsa05034,hsa05165,hsa05203 Thyroid hormone signaling pathway|Alcoholism|Human papillomavirus infection|Viral carcinogenesis HDAC4 578.023426423 584.164749779736 571.882103066264 0.978974002251757 -0.0306575469281349 0.835391983187528 1 0.885625 1.04524 1.02537 0.942023 GeneID:9759,Genbank:XM_011512221.1,HGNC:HGNC:14063,MIM:605314 histone deacetylase 4 GO:0000118,GO:0000122,GO:0001047,GO:0001085,GO:0001501,GO:0002076,GO:0003714,GO:0004407,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006338,GO:0006351,GO:0006476,GO:0006954,GO:0007399,GO:0008134,GO:0008270,GO:0008284,GO:0008285,GO:0010592,GO:0010832,GO:0010882,GO:0014894,GO:0014898,GO:0014911,GO:0016575,GO:0017053,GO:0019901,GO:0030018,GO:0030183,GO:0030955,GO:0031594,GO:0031672,GO:0032041,GO:0033235,GO:0033558,GO:0033613,GO:0034983,GO:0040029,GO:0042113,GO:0042493,GO:0042641,GO:0042802,GO:0042826,GO:0043234,GO:0043393,GO:0043433,GO:0043525,GO:0045668,GO:0045820,GO:0045892,GO:0045893,GO:0045944,GO:0048661,GO:0048742,GO:0051091,GO:0070491,GO:0070555,GO:0070932,GO:0070933,GO:0071260,GO:0071356,GO:0071374,GO:1902894,GO:1903428,GO:1990841 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|core promoter binding|RNA polymerase II transcription factor binding|skeletal system development|osteoblast development|transcription corepressor activity|histone deacetylase activity|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin remodeling|transcription, DNA-templated|protein deacetylation|inflammatory response|nervous system development|transcription factor binding|zinc ion binding|positive regulation of cell proliferation|negative regulation of cell proliferation|positive regulation of lamellipodium assembly|negative regulation of myotube differentiation|regulation of cardiac muscle contraction by calcium ion signaling|response to denervation involved in regulation of muscle adaptation|cardiac muscle hypertrophy in response to stress|positive regulation of smooth muscle cell migration|histone deacetylation|transcriptional repressor complex|protein kinase binding|Z disc|B cell differentiation|potassium ion binding|neuromuscular junction|A band|NAD-dependent histone deacetylase activity (H3-K14 specific)|positive regulation of protein sumoylation|protein deacetylase activity|activating transcription factor binding|peptidyl-lysine deacetylation|regulation of gene expression, epigenetic|B cell activation|response to drug|actomyosin|identical protein binding|histone deacetylase binding|protein complex|regulation of protein binding|negative regulation of DNA binding transcription factor activity|positive regulation of neuron apoptotic process|negative regulation of osteoblast differentiation|negative regulation of glycolytic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of smooth muscle cell proliferation|regulation of skeletal muscle fiber development|positive regulation of DNA binding transcription factor activity|repressing transcription factor binding|response to interleukin-1|histone H3 deacetylation|histone H4 deacetylation|cellular response to mechanical stimulus|cellular response to tumor necrosis factor|cellular response to parathyroid hormone stimulus|negative regulation of pri-miRNA transcription from RNA polymerase II promoter|positive regulation of reactive oxygen species biosynthetic process|promoter-specific chromatin binding hsa04371,hsa05034,hsa05165,hsa05203,hsa05206 Apelin signaling pathway|Alcoholism|Human papillomavirus infection|Viral carcinogenesis|MicroRNAs in cancer HDAC5 893.586130097734 840.755165647272 946.417094548195 1.12567502790135 0.170790394644675 0.277257721917072 1 5.12779 5.09128 5.5227 6.04352 GeneID:10014,Genbank:XM_011524149.2,HGNC:HGNC:14068,MIM:605315 histone deacetylase 5 GO:0000118,GO:0000122,GO:0001047,GO:0001085,GO:0003682,GO:0004407,GO:0005080,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006325,GO:0006338,GO:0006342,GO:0006351,GO:0006476,GO:0006954,GO:0008134,GO:0010830,GO:0010832,GO:0014823,GO:0016575,GO:0016607,GO:0030182,GO:0030183,GO:0032041,GO:0032869,GO:0033558,GO:0040029,GO:0042113,GO:0042220,GO:0042826,GO:0043234,GO:0043393,GO:0045892,GO:0045944,GO:0046872,GO:0051091,GO:0070491,GO:0071222,GO:0090051 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|core promoter binding|RNA polymerase II transcription factor binding|chromatin binding|histone deacetylase activity|protein kinase C binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|chromatin organization|chromatin remodeling|chromatin silencing|transcription, DNA-templated|protein deacetylation|inflammatory response|transcription factor binding|regulation of myotube differentiation|negative regulation of myotube differentiation|response to activity|histone deacetylation|nuclear speck|neuron differentiation|B cell differentiation|NAD-dependent histone deacetylase activity (H3-K14 specific)|cellular response to insulin stimulus|protein deacetylase activity|regulation of gene expression, epigenetic|B cell activation|response to cocaine|histone deacetylase binding|protein complex|regulation of protein binding|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|positive regulation of DNA binding transcription factor activity|repressing transcription factor binding|cellular response to lipopolysaccharide|negative regulation of cell migration involved in sprouting angiogenesis hsa04371,hsa05034,hsa05165,hsa05203 Apelin signaling pathway|Alcoholism|Human papillomavirus infection|Viral carcinogenesis HDAC6 817.246056340714 804.817274170969 829.674838510459 1.03088597267634 0.0438847635962653 0.793668254699601 1 4.15003 4.24807 4.5506 4.49953 GeneID:10013,Genbank:NM_001321225.1,HGNC:HGNC:14064,MIM:300272 histone deacetylase 6 GO:0000118,GO:0000209,GO:0001047,GO:0003779,GO:0004407,GO:0005634,GO:0005654,GO:0005737,GO:0005771,GO:0005829,GO:0005874,GO:0005875,GO:0005881,GO:0005901,GO:0006351,GO:0006476,GO:0006515,GO:0006886,GO:0006914,GO:0007026,GO:0008013,GO:0008017,GO:0008270,GO:0009636,GO:0009967,GO:0010033,GO:0010469,GO:0010506,GO:0010634,GO:0010727,GO:0010870,GO:0016234,GO:0016235,GO:0016241,GO:0016575,GO:0019899,GO:0030424,GO:0030425,GO:0031252,GO:0031593,GO:0031625,GO:0031647,GO:0032041,GO:0032418,GO:0034983,GO:0035967,GO:0040029,GO:0042826,GO:0042903,GO:0043014,GO:0043130,GO:0043162,GO:0043204,GO:0043241,GO:0043242,GO:0045598,GO:0045861,GO:0045892,GO:0048156,GO:0048471,GO:0048487,GO:0048668,GO:0051354,GO:0051646,GO:0051787,GO:0051788,GO:0051879,GO:0060271,GO:0060632,GO:0060765,GO:0060997,GO:0061734,GO:0070201,GO:0070301,GO:0070840,GO:0070842,GO:0070845,GO:0070846,GO:0070848,GO:0071218,GO:0090035,GO:0090042,GO:1901300,GO:1903146 histone deacetylase complex|protein polyubiquitination|core promoter binding|actin binding|histone deacetylase activity|nucleus|nucleoplasm|cytoplasm|multivesicular body|cytosol|microtubule|microtubule associated complex|cytoplasmic microtubule|caveola|transcription, DNA-templated|protein deacetylation|protein quality control for misfolded or incompletely synthesized proteins|intracellular protein transport|autophagy|negative regulation of microtubule depolymerization|beta-catenin binding|microtubule binding|zinc ion binding|response to toxic substance|positive regulation of signal transduction|response to organic substance|regulation of receptor activity|regulation of autophagy|positive regulation of epithelial cell migration|negative regulation of hydrogen peroxide metabolic process|positive regulation of receptor biosynthetic process|inclusion body|aggresome|regulation of macroautophagy|histone deacetylation|enzyme binding|axon|dendrite|cell leading edge|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|regulation of protein stability|NAD-dependent histone deacetylase activity (H3-K14 specific)|lysosome localization|peptidyl-lysine deacetylation|cellular response to topologically incorrect protein|regulation of gene expression, epigenetic|histone deacetylase binding|tubulin deacetylase activity|alpha-tubulin binding|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|perikaryon|protein complex disassembly|negative regulation of protein complex disassembly|regulation of fat cell differentiation|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|tau protein binding|perinuclear region of cytoplasm|beta-tubulin binding|collateral sprouting|negative regulation of oxidoreductase activity|mitochondrion localization|misfolded protein binding|response to misfolded protein|Hsp90 protein binding|cilium assembly|regulation of microtubule-based movement|regulation of androgen receptor signaling pathway|dendritic spine morphogenesis|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|regulation of establishment of protein localization|cellular response to hydrogen peroxide|dynein complex binding|aggresome assembly|polyubiquitinated misfolded protein transport|Hsp90 deacetylation|response to growth factor|cellular response to misfolded protein|positive regulation of chaperone-mediated protein complex assembly|tubulin deacetylation|positive regulation of hydrogen peroxide-mediated programmed cell death|regulation of autophagy of mitochondrion hsa05034,hsa05165,hsa05203 Alcoholism|Human papillomavirus infection|Viral carcinogenesis HDAC7 1453.29099563892 1447.86702742474 1458.7149638531 1.00749235684139 0.0107688940496755 0.970502569993675 1 8.29384 9.47161 9.32329 9.24844 GeneID:51564,Genbank:NM_001308090.1,HGNC:HGNC:14067,MIM:606542 histone deacetylase 7 GO:0000118,GO:0000122,GO:0001570,GO:0003682,GO:0003714,GO:0005080,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0007043,GO:0019789,GO:0019901,GO:0032041,GO:0032703,GO:0033613,GO:0045668,GO:0046872,GO:0070491,GO:0071889,GO:0090050,GO:1901223 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|vasculogenesis|chromatin binding|transcription corepressor activity|protein kinase C binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|cell-cell junction assembly|SUMO transferase activity|protein kinase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|negative regulation of interleukin-2 production|activating transcription factor binding|negative regulation of osteoblast differentiation|metal ion binding|repressing transcription factor binding|14-3-3 protein binding|positive regulation of cell migration involved in sprouting angiogenesis|negative regulation of NIK/NF-kappaB signaling hsa05034,hsa05165,hsa05203 Alcoholism|Human papillomavirus infection|Viral carcinogenesis HDAC8 689.077170780514 689.998521290601 688.155820270428 0.997329413088123 -0.00385799634731729 0.976206880866986 1 4.53312 4.95899 4.97921 4.94534 GeneID:55869,Genbank:NM_001166418.1,HGNC:HGNC:13315,MIM:300269 histone deacetylase 8 GO:0000118,GO:0000122,GO:0000228,GO:0003682,GO:0004407,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006325,GO:0006333,GO:0006351,GO:0007062,GO:0008134,GO:0030544,GO:0031397,GO:0031647,GO:0032041,GO:0032204,GO:0035984,GO:0045668,GO:0046872,GO:0051879,GO:0071922,GO:1904322,GO:2000616 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|nuclear chromosome|chromatin binding|histone deacetylase activity|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|chromatin organization|chromatin assembly or disassembly|transcription, DNA-templated|sister chromatid cohesion|transcription factor binding|Hsp70 protein binding|negative regulation of protein ubiquitination|regulation of protein stability|NAD-dependent histone deacetylase activity (H3-K14 specific)|regulation of telomere maintenance|cellular response to trichostatin A|negative regulation of osteoblast differentiation|metal ion binding|Hsp90 protein binding|regulation of cohesin loading|cellular response to forskolin|negative regulation of histone H3-K9 acetylation hsa05034,hsa05165,hsa05203 Alcoholism|Human papillomavirus infection|Viral carcinogenesis HDAC9 1371.14887274495 1448.18933468901 1294.1084108009 0.893604434035414 -0.162291750443672 0.47040868122829 1 3.96196 3.51095 3.80964 2.80942 GeneID:9734,Genbank:NM_001321868.1,HGNC:HGNC:14065,MIM:606543 histone deacetylase 9 GO:0000118,GO:0000122,GO:0001975,GO:0003714,GO:0004407,GO:0005080,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006351,GO:0006954,GO:0007507,GO:0008134,GO:0016575,GO:0030182,GO:0030183,GO:0032041,GO:0032869,GO:0033558,GO:0034983,GO:0035097,GO:0042113,GO:0042826,GO:0045892,GO:0046872,GO:0048742,GO:0051153,GO:0070491,GO:0070932,GO:0070933,GO:0090050 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|response to amphetamine|transcription corepressor activity|histone deacetylase activity|protein kinase C binding|nucleus|nucleoplasm|transcription factor complex|cytoplasm|transcription, DNA-templated|inflammatory response|heart development|transcription factor binding|histone deacetylation|neuron differentiation|B cell differentiation|NAD-dependent histone deacetylase activity (H3-K14 specific)|cellular response to insulin stimulus|protein deacetylase activity|peptidyl-lysine deacetylation|histone methyltransferase complex|B cell activation|histone deacetylase binding|negative regulation of transcription, DNA-templated|metal ion binding|regulation of skeletal muscle fiber development|regulation of striated muscle cell differentiation|repressing transcription factor binding|histone H3 deacetylation|histone H4 deacetylation|positive regulation of cell migration involved in sprouting angiogenesis hsa05034,hsa05165,hsa05203 Alcoholism|Human papillomavirus infection|Viral carcinogenesis HDC 1.93853326624189 0 3.87706653248377 Inf Inf 0.142706408912277 1 0 0 0.0256042 0.0119391 GeneID:3067,Genbank:XM_017022097.1,HGNC:HGNC:4855,MIM:142704 histidine decarboxylase GO:0001694,GO:0004398,GO:0005829,GO:0006547,GO:0006548,GO:0030170,GO:0042423 histamine biosynthetic process|histidine decarboxylase activity|cytosol|histidine metabolic process|histidine catabolic process|pyridoxal phosphate binding|catecholamine biosynthetic process hsa00340 Histidine metabolism HDDC2 1611.01857894234 1732.41788816661 1489.61926971808 0.85984985487221 -0.217843333377834 0.133286192104308 1 22.9272 23.848 19.4269 22.0237 GeneID:51020,Genbank:NM_016063.2,HGNC:HGNC:21078 HD domain containing 2 GO:0005739,GO:0070062 mitochondrion|extracellular exosome HDDC3 272.046793754801 270.783886214939 273.309701294664 1.00932778945982 0.0133947804207314 0.980641248315331 1 6.90002 8.38555 7.02931 7.43873 GeneID:374659,Genbank:NM_001286451.1,HGNC:HGNC:30522 HD domain containing 3 GO:0008893,GO:0046872 guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity|metal ion binding hsa00230 Purine metabolism HDGF 14422.3889491528 13532.3836656899 15312.3942326157 1.13153710468902 0.178283893374721 0.171016132678775 1 118.023 119.35 142.703 133.445 GeneID:3068,Genbank:NM_001126050.1,HGNC:HGNC:4856,MIM:600339 heparin binding growth factor GO:0000122,GO:0000166,GO:0001106,GO:0001222,GO:0003677,GO:0003723,GO:0005576,GO:0005615,GO:0005654,GO:0005737,GO:0006351,GO:0007165,GO:0008083,GO:0008201,GO:0008283,GO:0017053,GO:0031012,GO:0036498 negative regulation of transcription from RNA polymerase II promoter|nucleotide binding|RNA polymerase II transcription corepressor activity|transcription corepressor binding|DNA binding|RNA binding|extracellular region|extracellular space|nucleoplasm|cytoplasm|transcription, DNA-templated|signal transduction|growth factor activity|heparin binding|cell proliferation|transcriptional repressor complex|extracellular matrix|IRE1-mediated unfolded protein response HDGFL2 2228.31908558752 2043.35042872333 2413.28774245172 1.18104447897345 0.240063298677552 0.114312063293833 1 19.615 20.446 22.4013 25.2592 GeneID:84717,Genbank:NM_001001520.2,HGNC:HGNC:14680,MIM:617884 HDGF like 2 GO:0005634,GO:0030307 nucleus|positive regulation of cell growth HDGFL3 1377.01766827475 1428.4914430622 1325.54389348729 0.927932680258678 -0.107907950504209 0.480814936833489 1 9.24128 8.21305 8.94128 7.42655 GeneID:50810,Genbank:XM_006720554.4,HGNC:HGNC:24937,MIM:616643 HDGF like 3 GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0007026,GO:0008017,GO:0008083,GO:0008283,GO:0015631,GO:0031175,GO:0046785 extracellular region|nucleus|nucleoplasm|cytosol|negative regulation of microtubule depolymerization|microtubule binding|growth factor activity|cell proliferation|tubulin binding|neuron projection development|microtubule polymerization HDHD2 256.139575932032 276.749969931834 235.529181932229 0.851054047052803 -0.232677340250965 0.313375543276396 1 2.05405 1.50107 1.62311 1.62189 GeneID:84064,Genbank:NM_001318765.1,HGNC:HGNC:25364 haloacid dehalogenase like hydrolase domain containing 2 GO:0016311,GO:0016791,GO:0019899,GO:0046872,GO:0070062 dephosphorylation|phosphatase activity|enzyme binding|metal ion binding|extracellular exosome HDHD3 136.138895210833 135.632074480894 136.645715940771 1.00747346425067 0.0107418402439383 0.992736497281529 1 2.91291 2.76748 2.40484 3.47083 GeneID:81932,Genbank:NM_001304511.1,HGNC:HGNC:28171 haloacid dehalogenase like hydrolase domain containing 3 GO:0005739,GO:0008152,GO:0016787 mitochondrion|metabolic process|hydrolase activity HDHD5 930.783443595729 993.645600401152 867.921286790307 0.873471674850583 -0.19516717504833 0.198026420423982 1 10.52 11.3305 9.19951 10.0269 GeneID:27440,Genbank:NM_017829.5,HGNC:HGNC:1843 haloacid dehalogenase like hydrolase domain containing 5 GO:0005739,GO:0046474 mitochondrion|glycerophospholipid biosynthetic process HDLBP 16730.4691546059 15398.9691547832 18061.9691544287 1.17293365373216 0.230121410520175 0.0747478618145944 0.94116490159005 63.8953 63.1175 78.9042 71.8713 GeneID:3069,Genbank:NM_005336.5,HGNC:HGNC:4857,MIM:142695 high density lipoprotein binding protein GO:0003723,GO:0005634,GO:0005829,GO:0005886,GO:0006869,GO:0008203,GO:0008289,GO:0034364,GO:0034384,GO:0045296 RNA binding|nucleus|cytosol|plasma membrane|lipid transport|cholesterol metabolic process|lipid binding|high-density lipoprotein particle|high-density lipoprotein particle clearance|cadherin binding HDX 54.7686428912594 52.8208332060625 56.7164525764562 1.07375156986252 0.102660240636124 0.840518043245683 1 0.301327 0.200198 0.356407 0.135934 GeneID:139324,Genbank:NM_144657.4,HGNC:HGNC:26411,MIM:300994 highly divergent homeobox GO:0003677,GO:0005634 DNA binding|nucleus HEATR1 1105.69150869872 1226.48023225471 984.902785142727 0.80303192765865 -0.316470746049997 0.157240440215438 1 5.57501 4.99081 4.94812 3.47529 GeneID:55127,Genbank:NM_018072.5,HGNC:HGNC:25517 HEAT repeat containing 1 GO:0000462,GO:0001650,GO:0003723,GO:0005654,GO:0005730,GO:0005739,GO:0006351,GO:0006364,GO:0016020,GO:0030515,GO:0030686,GO:0032040,GO:0034455,GO:0045943,GO:2000234 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|fibrillar center|RNA binding|nucleoplasm|nucleolus|mitochondrion|transcription, DNA-templated|rRNA processing|membrane|snoRNA binding|90S preribosome|small-subunit processome|t-UTP complex|positive regulation of transcription from RNA polymerase I promoter|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes HEATR3 860.418308805186 847.038832977601 873.79778463277 1.03159117458771 0.0448713358270058 0.771959932386119 1 7.59918 7.71754 8.15 7.4509 GeneID:55027,Genbank:NM_001329729.1,HGNC:HGNC:26087,MIM:614951 HEAT repeat containing 3 GO:0006606,GO:0042273,GO:0051082 protein import into nucleus|ribosomal large subunit biogenesis|unfolded protein binding HEATR5A 273.173799092867 272.012952046531 274.334646139203 1.00853523361738 0.0122614860105208 0.945856585977297 1 1.47284 1.22064 1.56889 1.16136 GeneID:25938,Genbank:NM_015473.3,HGNC:HGNC:20276 HEAT repeat containing 5A HEATR5B 367.875531503423 401.312315921557 334.438747085288 0.833362779602957 -0.262983428349856 0.276171235110563 1 2.21661 1.91983 2.08463 1.4958 GeneID:54497,Genbank:NM_019024.2,HGNC:HGNC:29273 HEAT repeat containing 5B GO:0016020,GO:0070062 membrane|extracellular exosome HEATR6 814.617234027273 828.13777071022 801.096697344326 0.967347131935906 -0.0478944020261613 0.771268536229922 1 3.79904 3.75276 3.86029 3.72209 GeneID:63897,Genbank:XM_017024938.1,HGNC:HGNC:24076 HEAT repeat containing 6 GO:0003723 RNA binding HEBP1 357.763196855626 359.830768545414 355.695625165838 0.988508088409747 -0.0166753241166019 0.933754122675226 1 12.273 13.0553 12.2767 13.0734 GeneID:50865,Genbank:NM_015987.4,HGNC:HGNC:17176,MIM:605826 heme binding protein 1 GO:0005576,GO:0005737,GO:0007186,GO:0007623,GO:0020037,GO:0070062 extracellular region|cytoplasm|G-protein coupled receptor signaling pathway|circadian rhythm|heme binding|extracellular exosome HEBP2 1511.33420011512 1495.2764408982 1527.39195933203 1.02147798062981 0.0306581051200287 0.870271431114476 1 44.6677 44.2089 41.5195 48.9713 GeneID:23593,Genbank:NM_001326380.1,HGNC:HGNC:15716,MIM:605825 heme binding protein 2 GO:0005576,GO:0005737,GO:0005739,GO:0010917,GO:0010940,GO:0035578,GO:0035794,GO:0043312,GO:0070062 extracellular region|cytoplasm|mitochondrion|negative regulation of mitochondrial membrane potential|positive regulation of necrotic cell death|azurophil granule lumen|positive regulation of mitochondrial membrane permeability|neutrophil degranulation|extracellular exosome HECA 354.651268576138 347.703445010319 361.599092141956 1.03996407666086 0.0565336944064283 0.847031259008051 1 3.2342 2.7823 3.89549 2.46757 GeneID:51696,Genbank:NM_016217.2,HGNC:HGNC:21041,MIM:607977 hdc homolog, cell cycle regulator GO:0005634,GO:0005737,GO:0016020,GO:0030323,GO:0045930 nucleus|cytoplasm|membrane|respiratory tube development|negative regulation of mitotic cell cycle HECTD1 705.108388598459 729.662844882114 680.553932314805 0.932696432452658 -0.100520495759666 0.786952191001935 1 2.75467 2.25961 2.88761 1.79491 GeneID:25831,Genbank:NM_015382.3,HGNC:HGNC:20157 HECT domain E3 ubiquitin protein ligase 1 GO:0005737,GO:0046872,GO:0061630 cytoplasm|metal ion binding|ubiquitin protein ligase activity HECTD2 126.884091317493 122.890218030003 130.877964604983 1.06499904307298 0.0908521341558206 0.801705124669078 1 0.641758 0.622306 0.892531 0.578901 GeneID:143279,Genbank:NM_001348365.1,HGNC:HGNC:26736 HECT domain E3 ubiquitin protein ligase 2 GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0061630 protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|ubiquitin protein ligase activity HECTD3 1563.10524145238 1526.43807986877 1599.77240303598 1.04804277627397 0.0676976022369007 0.63567650471011 1 16.1831 15.0789 17.1042 15.8339 GeneID:79654,Genbank:XM_024449803.1,HGNC:HGNC:26117 HECT domain E3 ubiquitin protein ligase 3 GO:0004842,GO:0005737,GO:0019905,GO:0043161,GO:0048471,GO:0061630 ubiquitin-protein transferase activity|cytoplasm|syntaxin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|perinuclear region of cytoplasm|ubiquitin protein ligase activity HECTD4 1368.16647199254 1327.76233332647 1408.57061065861 1.06086049837677 0.0852349564109782 0.764466466433519 1 2.68394 2.9665 3.70793 2.42595 GeneID:283450,Genbank:NM_001109662.3,HGNC:HGNC:26611 HECT domain E3 ubiquitin protein ligase 4 GO:0005737,GO:0006006,GO:0016021,GO:0042593,GO:0061630 cytoplasm|glucose metabolic process|integral component of membrane|glucose homeostasis|ubiquitin protein ligase activity HECW1 20.5162613016136 22.1296483272353 18.9028742759919 0.854187739293074 -0.227374904690059 0.754207033449774 1 0.0650019 0.0537071 0.0616968 0.0423567 GeneID:23072,Genbank:XM_017011886.1,HGNC:HGNC:22195,MIM:610384 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 GO:0005737,GO:0005829,GO:0042787,GO:0043161,GO:0061630,GO:0090090 cytoplasm|cytosol|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity|negative regulation of canonical Wnt signaling pathway HECW2 5.64414922178467 4.01662376502878 7.27167467854057 1.81039477529667 0.856304326182062 0.551462139244546 1 0 0.0182966 0.0247534 0.0115379 GeneID:57520,Genbank:NM_001348768.1,HGNC:HGNC:29853,MIM:617245 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 GO:0005737,GO:0030071,GO:0042787,GO:0043161,GO:0061630,GO:0072686 cytoplasm|regulation of mitotic metaphase/anaphase transition|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity|mitotic spindle HEG1 2542.80038068396 2707.79657652639 2377.80418484153 0.878132502808544 -0.187489448154336 0.172230988705385 1 10.2844 10.5261 10.4671 8.1022 GeneID:57493,Genbank:NM_020733.1,HGNC:HGNC:29227,MIM:614182 heart development protein with EGF like domains 1 GO:0001570,GO:0001701,GO:0001886,GO:0001945,GO:0003017,GO:0003209,GO:0003222,GO:0003281,GO:0005509,GO:0005576,GO:0005911,GO:0007043,GO:0009791,GO:0009897,GO:0016021,GO:0030324,GO:0035264,GO:0048845,GO:0050878,GO:0055017,GO:0060039,GO:0090271 vasculogenesis|in utero embryonic development|endothelial cell morphogenesis|lymph vessel development|lymph circulation|cardiac atrium morphogenesis|ventricular trabecula myocardium morphogenesis|ventricular septum development|calcium ion binding|extracellular region|cell-cell junction|cell-cell junction assembly|post-embryonic development|external side of plasma membrane|integral component of membrane|lung development|multicellular organism growth|venous blood vessel morphogenesis|regulation of body fluid levels|cardiac muscle tissue growth|pericardium development|positive regulation of fibroblast growth factor production HELB 20.2879748428523 24.5800053370221 15.9959443486824 0.650770580777277 -0.619779061956315 0.333010273900595 1 0.148321 0.16614 0.151136 0.0738318 GeneID:92797,Genbank:NM_033647.4,HGNC:HGNC:17196,MIM:614539 DNA helicase B GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005737,GO:0006260,GO:0006269,GO:0006281,GO:0006396,GO:0006974,GO:0017116,GO:0035861,GO:0043141,GO:1903775,GO:2000042 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|cytoplasm|DNA replication|DNA replication, synthesis of RNA primer|DNA repair|RNA processing|cellular response to DNA damage stimulus|single-stranded DNA-dependent ATP-dependent DNA helicase activity|site of double-strand break|ATP-dependent 5'-3' DNA helicase activity|regulation of DNA double-strand break processing|negative regulation of double-strand break repair via homologous recombination HELLS 541.840681168881 575.225760683208 508.455601654553 0.883923559074701 -0.178006482863655 0.619371689011807 1 1.83569 1.37147 1.69789 1.19351 GeneID:3070,Genbank:NM_001289071.1,HGNC:HGNC:4861,MIM:603946 helicase, lymphoid specific GO:0000775,GO:0004386,GO:0005524,GO:0005634,GO:0005721,GO:0006346,GO:0006351,GO:0007049,GO:0007275,GO:0010216,GO:0031508,GO:0046651,GO:0051301 chromosome, centromeric region|helicase activity|ATP binding|nucleus|pericentric heterochromatin|methylation-dependent chromatin silencing|transcription, DNA-templated|cell cycle|multicellular organism development|maintenance of DNA methylation|pericentric heterochromatin assembly|lymphocyte proliferation|cell division HELQ 118.607730251388 126.214856639226 111.000603863549 0.879457512524334 -0.185314213552908 0.56664087736142 1 0.684705 0.659751 0.758612 0.572261 GeneID:113510,Genbank:NM_001297755.1,HGNC:HGNC:18536,MIM:606769 helicase, POLQ like GO:0000724,GO:0003677,GO:0004004,GO:0005524,GO:0005730,GO:0005737,GO:0010501 double-strand break repair via homologous recombination|DNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleolus|cytoplasm|RNA secondary structure unwinding HELZ 411.645991797969 393.825957722394 429.466025873544 1.0904970011557 0.124985802602464 0.753064448067297 1 1.2151 0.844571 1.47233 0.867899 GeneID:9931,Genbank:NM_001330447.1,HGNC:HGNC:16878,MIM:606699 helicase with zinc finger GO:0003723,GO:0004386,GO:0005524,GO:0005634,GO:0016020,GO:0046872 RNA binding|helicase activity|ATP binding|nucleus|membrane|metal ion binding HELZ2 2001.49161392019 984.210799250978 3018.7724285894 3.06720108221409 1.61692275115125 0.347585282947573 1 3.81438 4.71906 24.1528 3.80169 GeneID:85441,Genbank:NM_001037335.2,HGNC:HGNC:30021,MIM:611265 helicase with zinc finger 2 GO:0003677,GO:0003723,GO:0004386,GO:0005524,GO:0005654,GO:0006351,GO:0016020,GO:0019216,GO:0030374,GO:0045944,GO:0046872 DNA binding|RNA binding|helicase activity|ATP binding|nucleoplasm|transcription, DNA-templated|membrane|regulation of lipid metabolic process|ligand-dependent nuclear receptor transcription coactivator activity|positive regulation of transcription from RNA polymerase II promoter|metal ion binding HEMK1 419.279248373324 408.722238881565 429.836257865082 1.05165860081726 0.0726664395685349 0.718962952256866 1 0.91188 1.09586 1.12619 1.18513 GeneID:51409,Genbank:XM_011533813.2,HGNC:HGNC:24923 HemK methyltransferase family member 1 GO:0003677,GO:0005739,GO:0006306,GO:0008170,GO:0008276,GO:0008757 DNA binding|mitochondrion|DNA methylation|N-methyltransferase activity|protein methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity HEPACAM2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0144687 0 0 GeneID:253012,Genbank:NM_001346642.1,HGNC:HGNC:27364,MIM:614133 HEPACAM family member 2 GO:0000139,GO:0005794,GO:0005813,GO:0005819,GO:0007098,GO:0016021,GO:0030496,GO:0051301 Golgi membrane|Golgi apparatus|centrosome|spindle|centrosome cycle|integral component of membrane|midbody|cell division HEPH 129.227933612415 124.21635341182 134.23951381301 1.08069114996445 0.111954275080797 0.684912587189229 1 0.741691 0.706726 0.771976 0.778639 GeneID:9843,Genbank:XM_017029998.2,HGNC:HGNC:4866,MIM:300167 hephaestin hsa00860,hsa04978 Porphyrin and chlorophyll metabolism|Mineral absorption HEPHL1 1.29177983152393 1.61429302992691 0.969266633120943 0.600427936658332 -0.735936990778882 0.974657200381333 1 0.0123324 0 0 0.00551338 GeneID:341208,Genbank:NM_001098672.1,HGNC:HGNC:30477 hephaestin like 1 GO:0004322,GO:0005507,GO:0006825,GO:0016021,GO:0055114 ferroxidase activity|copper ion binding|copper ion transport|integral component of membrane|oxidation-reduction process HERC1 1093.81299191219 1073.28303954336 1114.34294428102 1.03825636223147 0.0541627123422031 0.831525880599394 1 2.35064 2.0787 2.79654 1.86643 GeneID:8925,Genbank:NM_003922.3,HGNC:HGNC:4867,MIM:605109 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 GO:0004842,GO:0005086,GO:0005737,GO:0005794,GO:0005829,GO:0010507,GO:0016020,GO:0021702,GO:0031175,GO:0050885 ubiquitin-protein transferase activity|ARF guanyl-nucleotide exchange factor activity|cytoplasm|Golgi apparatus|cytosol|negative regulation of autophagy|membrane|cerebellar Purkinje cell differentiation|neuron projection development|neuromuscular process controlling balance hsa04120 Ubiquitin mediated proteolysis HERC2 4774.87563355293 4677.15704921012 4872.59421789574 1.04178546211499 0.0590582098524799 0.774701541847418 1 9.66688 9.98063 12.1687 8.55181 GeneID:8924,Genbank:NM_004667.5,HGNC:HGNC:4868,MIM:605837 HECT and RLD domain containing E3 ubiquitin protein ligase 2 hsa04120 Ubiquitin mediated proteolysis HERC3 595.535900773571 569.730131058054 621.341670489087 1.09058945036869 0.125108104972555 0.441489100318925 1 1.81885 1.68847 2.20529 1.75747 GeneID:8916,Genbank:NM_014606.2,HGNC:HGNC:4876,MIM:605200 HECT and RLD domain containing E3 ubiquitin protein ligase 3 GO:0005737,GO:0005829,GO:0031410,GO:0061630 cytoplasm|cytosol|cytoplasmic vesicle|ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis HERC4 627.579726396304 691.976390206937 563.183062585671 0.813876124324487 -0.297118868482654 0.112430051970845 1 3.1292 2.68635 2.67464 2.12466 GeneID:26091,Genbank:NM_001278186.1,HGNC:HGNC:24521,MIM:609248 HECT and RLD domain containing E3 ubiquitin protein ligase 4 GO:0001650,GO:0005737,GO:0005829,GO:0007283,GO:0030154,GO:0061630 fibrillar center|cytoplasm|cytosol|spermatogenesis|cell differentiation|ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis HERC5 414.379120144735 280.392192154491 548.366048134978 1.95571083460426 0.967693073601904 0.329355299294343 1 2.63015 2.36228 7.84285 2.40887 GeneID:51191,Genbank:XM_011532022.2,HGNC:HGNC:24368,MIM:608242 HECT and RLD domain containing E3 ubiquitin protein ligase 5 GO:0000079,GO:0000209,GO:0003723,GO:0004842,GO:0005737,GO:0005829,GO:0032020,GO:0032480,GO:0042296,GO:0045087,GO:0048471,GO:0050688,GO:0051607,GO:0061630 regulation of cyclin-dependent protein serine/threonine kinase activity|protein polyubiquitination|RNA binding|ubiquitin-protein transferase activity|cytoplasm|cytosol|ISG15-protein conjugation|negative regulation of type I interferon production|ISG15 transferase activity|innate immune response|perinuclear region of cytoplasm|regulation of defense response to virus|defense response to virus|ubiquitin protein ligase activity HERC6 313.611275971496 193.689805629325 433.532746313668 2.23828375946303 1.16239294624257 0.436288756731509 1 1.64587 1.48006 6.0932 1.04416 GeneID:55008,Genbank:XM_005263083.4,HGNC:HGNC:26072,MIM:609249 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 GO:0000209,GO:0002244,GO:0004842,GO:0005634,GO:0005737,GO:0005829,GO:0061630 protein polyubiquitination|hematopoietic progenitor cell differentiation|ubiquitin-protein transferase activity|nucleus|cytoplasm|cytosol|ubiquitin protein ligase activity HERPUD1 1771.87997949001 1742.44186427067 1801.31809470935 1.03378949487266 0.0479424471411632 0.751714719233152 1 36.5721 39.1735 39.7027 39.7848 GeneID:9709,Genbank:NM_014685.3,HGNC:HGNC:13744,MIM:608070 homocysteine inducible ER protein with ubiquitin like domain 1 GO:0005783,GO:0005789,GO:0006511,GO:0006986,GO:0016020,GO:0030970,GO:0031396,GO:0032092,GO:0032469,GO:0034704,GO:0034976,GO:0036499,GO:0043154,GO:0044325,GO:1902236,GO:1903071,GO:1990037,GO:2001243 endoplasmic reticulum|endoplasmic reticulum membrane|ubiquitin-dependent protein catabolic process|response to unfolded protein|membrane|retrograde protein transport, ER to cytosol|regulation of protein ubiquitination|positive regulation of protein binding|endoplasmic reticulum calcium ion homeostasis|calcium channel complex|response to endoplasmic reticulum stress|PERK-mediated unfolded protein response|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|ion channel binding|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|Lewy body core|negative regulation of intrinsic apoptotic signaling pathway hsa04141 Protein processing in endoplasmic reticulum HERPUD2 638.15475837473 625.92464614888 650.38487060058 1.0390785450009 0.0553047131452234 0.735369576549715 1 8.207 7.73441 8.86524 8.08201 GeneID:64224,Genbank:XM_017012506.2,HGNC:HGNC:21915 HERPUD family member 2 GO:0006986,GO:0007283,GO:0016021 response to unfolded protein|spermatogenesis|integral component of membrane HES1 406.837631927599 384.804792735024 428.870471120175 1.11451436992755 0.156415218023918 0.401379905527621 1 12.2396 12.7821 13.3404 14.3083 GeneID:3280,Genbank:NM_005524.3,HGNC:HGNC:5192,MIM:139605 hes family bHLH transcription factor 1 GO:0000122,GO:0001078,GO:0001889,GO:0003143,GO:0003151,GO:0003266,GO:0003281,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006461,GO:0007155,GO:0007219,GO:0007224,GO:0007262,GO:0007399,GO:0008134,GO:0008284,GO:0016477,GO:0021537,GO:0021555,GO:0021557,GO:0021558,GO:0021575,GO:0021861,GO:0021984,GO:0030324,GO:0030513,GO:0030901,GO:0031016,GO:0035019,GO:0035910,GO:0042102,GO:0042531,GO:0042668,GO:0042803,GO:0042826,GO:0043388,GO:0043565,GO:0045598,GO:0045608,GO:0045747,GO:0045892,GO:0045944,GO:0045977,GO:0046331,GO:0046427,GO:0048469,GO:0048538,GO:0048667,GO:0048711,GO:0048715,GO:0048844,GO:0050678,GO:0051087,GO:0060122,GO:0060164,GO:0060253,GO:0060412,GO:0060675,GO:0060716,GO:0061009,GO:0061106,GO:0061309,GO:0061626,GO:0071820,GO:0072012,GO:0072049,GO:0072050,GO:0072141,GO:0072282,GO:0090102,GO:0090162,GO:0097084,GO:0097150,GO:1903955,GO:2000227,GO:2000737,GO:2000974,GO:2000978 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|liver development|embryonic heart tube morphogenesis|outflow tract morphogenesis|regulation of secondary heart field cardioblast proliferation|ventricular septum development|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|protein complex assembly|cell adhesion|Notch signaling pathway|smoothened signaling pathway|STAT protein import into nucleus|nervous system development|transcription factor binding|positive regulation of cell proliferation|cell migration|telencephalon development|midbrain-hindbrain boundary morphogenesis|oculomotor nerve development|trochlear nerve development|hindbrain morphogenesis|forebrain radial glial cell differentiation|adenohypophysis development|lung development|positive regulation of BMP signaling pathway|midbrain development|pancreas development|somatic stem cell population maintenance|ascending aorta morphogenesis|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|auditory receptor cell fate determination|protein homodimerization activity|histone deacetylase binding|positive regulation of DNA binding|sequence-specific DNA binding|regulation of fat cell differentiation|negative regulation of inner ear auditory receptor cell differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle, embryonic|lateral inhibition|positive regulation of JAK-STAT cascade|cell maturation|thymus development|cell morphogenesis involved in neuron differentiation|positive regulation of astrocyte differentiation|negative regulation of oligodendrocyte differentiation|artery morphogenesis|regulation of epithelial cell proliferation|chaperone binding|inner ear receptor cell stereocilium organization|regulation of timing of neuron differentiation|negative regulation of glial cell proliferation|ventricular septum morphogenesis|ureteric bud morphogenesis|labyrinthine layer blood vessel development|common bile duct development|negative regulation of stomach neuroendocrine cell differentiation|cardiac neural crest cell development involved in outflow tract morphogenesis|pharyngeal arch artery morphogenesis|N-box binding|glomerulus vasculature development|comma-shaped body morphogenesis|S-shaped body morphogenesis|renal interstitial fibroblast development|metanephric nephron tubule morphogenesis|cochlea development|establishment of epithelial cell polarity|vascular smooth muscle cell development|neuronal stem cell population maintenance|positive regulation of protein targeting to mitochondrion|negative regulation of pancreatic A cell differentiation|negative regulation of stem cell differentiation|negative regulation of pro-B cell differentiation|negative regulation of forebrain neuron differentiation hsa03460,hsa04330,hsa04950,hsa05165,hsa05169,hsa05200,hsa05224 Fanconi anemia pathway|Notch signaling pathway|Maturity onset diabetes of the young|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Breast cancer HES2 3.5426258653319 5.6309167949557 1.45433493570811 0.258276758237831 -1.95301027057066 0.277333748151692 1 0.0550663 0.0589187 0.0205921 0.00961319 GeneID:54626,Genbank:NM_019089.4,HGNC:HGNC:16005,MIM:609970 hes family bHLH transcription factor 2 GO:0000978,GO:0001078,GO:0005634,GO:0006351,GO:0008134,GO:0046983 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|transcription, DNA-templated|transcription factor binding|protein dimerization activity hsa05165 Human papillomavirus infection HES4 406.219811483203 352.931551298434 459.508071667973 1.30197504297205 0.38070179433647 0.216898320177493 1 11.0312 9.00145 15.8075 11.4732 GeneID:57801,Genbank:XM_005244771.4,HGNC:HGNC:24149,MIM:608060 hes family bHLH transcription factor 4 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0007399,GO:0008134,GO:0030154,GO:0046983 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|nervous system development|transcription factor binding|cell differentiation|protein dimerization activity hsa05165 Human papillomavirus infection HES6 216.429239880794 210.890330972517 221.96814878907 1.05252880853033 0.0738597215149867 0.759202859371589 1 8.05466 8.44957 9.69879 9.25115 GeneID:55502,Genbank:NM_001142853.2,HGNC:HGNC:18254,MIM:610331 hes family bHLH transcription factor 6 GO:0000977,GO:0001227,GO:0003700,GO:0003712,GO:0005634,GO:0005667,GO:0006351,GO:0006355,GO:0007399,GO:0008134,GO:0030154,GO:0046983 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|transcription cofactor activity|nucleus|transcription factor complex|transcription, DNA-templated|regulation of transcription, DNA-templated|nervous system development|transcription factor binding|cell differentiation|protein dimerization activity hsa05165 Human papillomavirus infection HES7 204.702527774938 203.904869831275 205.500185718601 1.00782382435812 0.0112434662794558 1 1 2.29704 2.93322 2.90636 2.3116 GeneID:84667,Genbank:XM_024451007.1,HGNC:HGNC:15977,MIM:608059 hes family bHLH transcription factor 7 GO:0000122,GO:0000977,GO:0001501,GO:0001756,GO:0003677,GO:0005634,GO:0006351,GO:0007219,GO:0007498,GO:0008134,GO:0014807,GO:0036342,GO:0046983,GO:0048511 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|skeletal system development|somitogenesis|DNA binding|nucleus|transcription, DNA-templated|Notch signaling pathway|mesoderm development|transcription factor binding|regulation of somitogenesis|post-anal tail morphogenesis|protein dimerization activity|rhythmic process hsa05165 Human papillomavirus infection HESX1 34.4543812091149 27.2224674455487 41.6862949726811 1.53131949027264 0.614775314154051 0.207081880901851 1 0.458953 0.387435 0.84511 0.494786 GeneID:8820,Genbank:XM_005265526.4,HGNC:HGNC:4877,MIM:601802 HESX homeobox 1 GO:0000978,GO:0001078,GO:0003677,GO:0003682,GO:0005634,GO:0006351,GO:0007420,GO:0008022,GO:0021983,GO:0030916,GO:0043584,GO:0047485,GO:0048853 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|chromatin binding|nucleus|transcription, DNA-templated|brain development|protein C-terminus binding|pituitary gland development|otic vesicle formation|nose development|protein N-terminus binding|forebrain morphogenesis hsa04550 Signaling pathways regulating pluripotency of stem cells HEXA 4496.08041861605 4379.30560002965 4612.85523720246 1.05333028989145 0.0749578892335681 0.607444950928244 1 53.5459 57.1303 56.0227 62.4633 GeneID:3073,Genbank:NM_000520.5,HGNC:HGNC:4878,MIM:606869 hexosaminidase subunit alpha hsa00511,hsa00520,hsa00531,hsa00603,hsa00604,hsa04142 Other glycan degradation|Amino sugar and nucleotide sugar metabolism|Glycosaminoglycan degradation|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series|Lysosome HEXB 4664.03963057657 4215.60889211822 5112.47036903493 1.21274779038291 0.278279550955927 0.0348852444925048 0.731311617528739 77.4122 72.1162 96.3488 87.053 GeneID:3074,Genbank:NM_001292004.1,HGNC:HGNC:4879,MIM:606873 hexosaminidase subunit beta hsa00511,hsa00520,hsa00531,hsa00603,hsa00604,hsa04142 Other glycan degradation|Amino sugar and nucleotide sugar metabolism|Glycosaminoglycan degradation|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series|Lysosome HEXDC 196.016554966923 187.502190848366 204.53091908548 1.09081882275651 0.125411500179872 0.639967023390762 1 1.77441 2.43631 2.54935 2.01441 GeneID:284004,Genbank:NM_001330542.1,HGNC:HGNC:26307,MIM:616864 hexosaminidase D GO:0004563,GO:0005634,GO:0005737,GO:0005975,GO:0015929,GO:0102148 beta-N-acetylhexosaminidase activity|nucleus|cytoplasm|carbohydrate metabolic process|hexosaminidase activity|N-acetyl-beta-D-galactosaminidase activity hsa00511 Other glycan degradation HEXIM1 4027.07049127985 3711.4718936833 4342.6690888764 1.17006654321359 0.22659058009443 0.0901577371136503 0.979717040875575 36.947 36.3379 43.4072 43.3125 GeneID:10614,Genbank:NM_006460.2,HGNC:HGNC:24953,MIM:607328 hexamethylene bisacetamide inducible 1 GO:0000122,GO:0002218,GO:0004861,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0007507,GO:0017069,GO:0045087,GO:0045736,GO:0045892,GO:0097322,GO:1901798 negative regulation of transcription from RNA polymerase II promoter|activation of innate immune response|cyclin-dependent protein serine/threonine kinase inhibitor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|heart development|snRNA binding|innate immune response|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|7SK snRNA binding|positive regulation of signal transduction by p53 class mediator HEXIM2 162.375076008264 137.698221293201 187.051930723327 1.35841936785107 0.441928933573303 0.0781314382793696 0.94157495521624 1.53257 1.85854 2.1829 2.55909 GeneID:124790,Genbank:XM_006721687.4,HGNC:HGNC:28591,MIM:615695 hexamethylene bisacetamide inducible 2 GO:0000122,GO:0004861,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0016607,GO:0017069,GO:0042802,GO:0045736,GO:0045892,GO:0097322 negative regulation of transcription from RNA polymerase II promoter|cyclin-dependent protein serine/threonine kinase inhibitor activity|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|nuclear speck|snRNA binding|identical protein binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|7SK snRNA binding HEY1 186.412296699244 157.665670258759 215.158923139728 1.36465295702363 0.448534108039743 0.0568613552014787 0.865676297440002 2.46693 2.56525 3.38355 3.98014 GeneID:23462,Genbank:NM_012258.3,HGNC:HGNC:4880,MIM:602953 hes related family bHLH transcription factor with YRPW motif 1 GO:0000122,GO:0000983,GO:0000988,GO:0001525,GO:0003184,GO:0003190,GO:0003203,GO:0003208,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0007219,GO:0008134,GO:0035912,GO:0035939,GO:0036304,GO:0045746,GO:0045892,GO:0045944,GO:0046983,GO:0060317,GO:0060347,GO:0060411,GO:0060412,GO:0060716,GO:0060842,GO:0061314,GO:0071385,GO:2000678,GO:2000820,GO:2001212 negative regulation of transcription from RNA polymerase II promoter|transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding|transcription factor activity, protein binding|angiogenesis|pulmonary valve morphogenesis|atrioventricular valve formation|endocardial cushion morphogenesis|cardiac ventricle morphogenesis|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|Notch signaling pathway|transcription factor binding|dorsal aorta morphogenesis|microsatellite binding|umbilical cord morphogenesis|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|cardiac epithelial to mesenchymal transition|heart trabecula formation|cardiac septum morphogenesis|ventricular septum morphogenesis|labyrinthine layer blood vessel development|arterial endothelial cell differentiation|Notch signaling involved in heart development|cellular response to glucocorticoid stimulus|negative regulation of transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|regulation of vasculogenesis hsa05165,hsa05200,hsa05224 Human papillomavirus infection|Pathways in cancer|Breast cancer HEY2 18.1086344632288 19.7371262472414 16.4801426792162 0.834981874907935 -0.260183213784799 0.705021592876403 1 0.0794246 0.184854 0.135785 0.102535 GeneID:23493,Genbank:XM_017010629.2,HGNC:HGNC:4881,MIM:604674 hes related family bHLH transcription factor with YRPW motif 2 GO:0000122,GO:0000983,GO:0000988,GO:0001102,GO:0001570,GO:0003150,GO:0003151,GO:0003184,GO:0003186,GO:0003195,GO:0003199,GO:0003208,GO:0003214,GO:0003215,GO:0003222,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0007219,GO:0008134,GO:0009948,GO:0010460,GO:0010621,GO:0010629,GO:0010667,GO:0014031,GO:0014898,GO:0017053,GO:0035910,GO:0035912,GO:0035939,GO:0036304,GO:0042803,GO:0042826,GO:0043565,GO:0045165,GO:0045607,GO:0045746,GO:0045892,GO:0045944,GO:0046982,GO:0051145,GO:0055015,GO:0060045,GO:0060317,GO:0060347,GO:0060411,GO:0060412,GO:0060413,GO:0060633,GO:0060716,GO:0060842,GO:0060948,GO:0060977,GO:0061156,GO:0061314,GO:0065004,GO:0090102,GO:0097084,GO:2000678,GO:2000723,GO:2000820,GO:2001212 negative regulation of transcription from RNA polymerase II promoter|transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding|transcription factor activity, protein binding|RNA polymerase II activating transcription factor binding|vasculogenesis|muscular septum morphogenesis|outflow tract morphogenesis|pulmonary valve morphogenesis|tricuspid valve morphogenesis|tricuspid valve formation|endocardial cushion to mesenchymal transition involved in heart valve formation|cardiac ventricle morphogenesis|cardiac left ventricle morphogenesis|cardiac right ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|Notch signaling pathway|transcription factor binding|anterior/posterior axis specification|positive regulation of heart rate|negative regulation of transcription by transcription factor localization|negative regulation of gene expression|negative regulation of cardiac muscle cell apoptotic process|mesenchymal cell development|cardiac muscle hypertrophy in response to stress|transcriptional repressor complex|ascending aorta morphogenesis|dorsal aorta morphogenesis|microsatellite binding|umbilical cord morphogenesis|protein homodimerization activity|histone deacetylase binding|sequence-specific DNA binding|cell fate commitment|regulation of inner ear auditory receptor cell differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|smooth muscle cell differentiation|ventricular cardiac muscle cell development|positive regulation of cardiac muscle cell proliferation|cardiac epithelial to mesenchymal transition|heart trabecula formation|cardiac septum morphogenesis|ventricular septum morphogenesis|atrial septum morphogenesis|negative regulation of transcription initiation from RNA polymerase II promoter|labyrinthine layer blood vessel development|arterial endothelial cell differentiation|cardiac vascular smooth muscle cell development|coronary vasculature morphogenesis|pulmonary artery morphogenesis|Notch signaling involved in heart development|protein-DNA complex assembly|cochlea development|vascular smooth muscle cell development|negative regulation of transcription regulatory region DNA binding|negative regulation of cardiac vascular smooth muscle cell differentiation|negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|regulation of vasculogenesis hsa05165,hsa05200,hsa05224 Human papillomavirus infection|Pathways in cancer|Breast cancer HFE 571.809525839694 474.341746467457 669.277305211931 1.41096015730475 0.496677249685409 0.00329681638087587 0.215562625323993 5.46736 5.2356 8.10491 7.37991 GeneID:3077,Genbank:NM_000410.3,HGNC:HGNC:4886,MIM:613609 homeostatic iron regulator HFM1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0074681 0 0 0 GeneID:164045,Genbank:XM_011540852.2,HGNC:HGNC:20193,MIM:615684 HFM1, ATP dependent DNA helicase homolog GO:0000712,GO:0003676,GO:0004004,GO:0005524,GO:0005730,GO:0005737,GO:0010501 resolution of meiotic recombination intermediates|nucleic acid binding|ATP-dependent RNA helicase activity|ATP binding|nucleolus|cytoplasm|RNA secondary structure unwinding HGD 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0 0 GeneID:3081,Genbank:NM_000187.3,HGNC:HGNC:4892,MIM:607474 homogentisate 1,2-dioxygenase GO:0004411,GO:0005829,GO:0006559,GO:0006572,GO:0042802,GO:0046872,GO:0070062 homogentisate 1,2-dioxygenase activity|cytosol|L-phenylalanine catabolic process|tyrosine catabolic process|identical protein binding|metal ion binding|extracellular exosome hsa00350 Tyrosine metabolism HGF 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00576842 0 0.00559848 0 GeneID:3082,Genbank:XM_006715956.2,HGNC:HGNC:4893,MIM:142409 hepatocyte growth factor hsa01521,hsa04010,hsa04014,hsa04015,hsa04151,hsa04510,hsa05144,hsa05200,hsa05205,hsa05211,hsa05218,hsa05225,hsa05226 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Malaria|Pathways in cancer|Proteoglycans in cancer|Renal cell carcinoma|Melanoma|Hepatocellular carcinoma|Gastric cancer HGFAC 2.21845827535682 2.49838328447175 1.93853326624189 0.775915080080181 -0.366029329396596 0.96446116579049 1 0 0 0 0.0227909 GeneID:3083,Genbank:NM_001297439.1,HGNC:HGNC:4894,MIM:604552 HGF activator GO:0004252,GO:0005576,GO:0005615,GO:0005829,GO:0006508,GO:0008236 serine-type endopeptidase activity|extracellular region|extracellular space|cytosol|proteolysis|serine-type peptidase activity HGH1 812.880232687728 799.994012391404 825.766452984053 1.03221579186025 0.045744607682085 0.79567919684136 1 18.3932 18.6584 19.3978 20.4012 GeneID:51236,Genbank:NM_016458.3,HGNC:HGNC:24161 HGH1 homolog HGS 3375.85691941295 3396.74832842903 3354.96551039688 0.987699171680619 -0.0178563947890478 0.887111713945516 1 27.9495 27.4812 27.9509 28.6921 GeneID:9146,Genbank:NM_004712.4,HGNC:HGNC:4897,MIM:604375 hepatocyte growth factor-regulated tyrosine kinase substrate GO:0005764,GO:0005768,GO:0005769,GO:0005829,GO:0006622,GO:0007165,GO:0008285,GO:0010324,GO:0010628,GO:0016197,GO:0016236,GO:0016579,GO:0019904,GO:0031901,GO:0032585,GO:0033565,GO:0036258,GO:0042059,GO:0042176,GO:0043231,GO:0043405,GO:0044389,GO:0046426,GO:0046872,GO:0061024,GO:0070062,GO:0072657,GO:1903543 lysosome|endosome|early endosome|cytosol|protein targeting to lysosome|signal transduction|negative regulation of cell proliferation|membrane invagination|positive regulation of gene expression|endosomal transport|macroautophagy|protein deubiquitination|protein domain specific binding|early endosome membrane|multivesicular body membrane|ESCRT-0 complex|multivesicular body assembly|negative regulation of epidermal growth factor receptor signaling pathway|regulation of protein catabolic process|intracellular membrane-bounded organelle|regulation of MAP kinase activity|ubiquitin-like protein ligase binding|negative regulation of JAK-STAT cascade|metal ion binding|membrane organization|extracellular exosome|protein localization to membrane|positive regulation of exosomal secretion hsa04144,hsa04145 Endocytosis|Phagosome HGSNAT 1327.85846090886 1335.0741697354 1320.64275208233 0.989190549873398 -0.0156796377271501 0.913431383770365 1 10.8576 11.2359 11.6521 10.5919 GeneID:138050,Genbank:XM_005273409.1,HGNC:HGNC:26527,MIM:610453 heparan-alpha-glucosaminide N-acetyltransferase GO:0005765,GO:0005886,GO:0006027,GO:0007041,GO:0015019,GO:0016021,GO:0016746,GO:0035579,GO:0043312,GO:0051259,GO:0070821 lysosomal membrane|plasma membrane|glycosaminoglycan catabolic process|lysosomal transport|heparan-alpha-glucosaminide N-acetyltransferase activity|integral component of membrane|transferase activity, transferring acyl groups|specific granule membrane|neutrophil degranulation|protein oligomerization|tertiary granule membrane hsa00531,hsa04142 Glycosaminoglycan degradation|Lysosome HHAT 409.529122045116 422.164872142514 396.893371947718 0.940138315946228 -0.0890550688950121 0.624746838869625 1 2.60988 2.78303 2.51588 2.57537 GeneID:55733,Genbank:XM_017001744.1,HGNC:HGNC:18270,MIM:605743 hedgehog acyltransferase GO:0005525,GO:0005789,GO:0007224,GO:0007275,GO:0008374,GO:0016021,GO:0016409,GO:0018345,GO:1903955 GTP binding|endoplasmic reticulum membrane|smoothened signaling pathway|multicellular organism development|O-acyltransferase activity|integral component of membrane|palmitoyltransferase activity|protein palmitoylation|positive regulation of protein targeting to mitochondrion HHATL 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0255808 0 0 GeneID:57467,Genbank:XM_006713275.2,HGNC:HGNC:13242,MIM:608116 hedgehog acyltransferase like GO:0005783,GO:0005789,GO:0016021,GO:0048471,GO:0060262 endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|perinuclear region of cytoplasm|negative regulation of N-terminal protein palmitoylation HHIP 16.0746778657402 15.1824048055703 16.9669509259102 1.11754041228601 0.16032700281839 0.887654765259025 1 0.0706719 0.148857 0.165396 0.0839691 GeneID:64399,Genbank:NM_022475.2,HGNC:HGNC:14866,MIM:606178 hedgehog interacting protein GO:0003824,GO:0005576,GO:0005634,GO:0005737,GO:0005887,GO:0007224,GO:0007405,GO:0008270,GO:0009953,GO:0009968,GO:0009986,GO:0040036,GO:0043066,GO:0045879,GO:0048705,GO:0060170,GO:0060441,GO:0097108 catalytic activity|extracellular region|nucleus|cytoplasm|integral component of plasma membrane|smoothened signaling pathway|neuroblast proliferation|zinc ion binding|dorsal/ventral pattern formation|negative regulation of signal transduction|cell surface|regulation of fibroblast growth factor receptor signaling pathway|negative regulation of apoptotic process|negative regulation of smoothened signaling pathway|skeletal system morphogenesis|ciliary membrane|epithelial tube branching involved in lung morphogenesis|hedgehog family protein binding hsa04024,hsa04340,hsa05200,hsa05217 cAMP signaling pathway|Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma HHIPL1 27.8403361360861 27.5684600234512 28.1122122487209 1.019723706903 0.0281783083957619 1 1 0.10107 0.115088 0.13492 0.100991 GeneID:84439,Genbank:XM_011537236.2,HGNC:HGNC:19710 HHIP like 1 GO:0003824,GO:0005044,GO:0005576,GO:0016020 catalytic activity|scavenger receptor activity|extracellular region|membrane HHIPL2 16.1672505268965 15.3745099043101 16.959991149483 1.10312401858927 0.141594994869233 0.887053262622508 1 0.125211 0.148406 0.118413 0.176443 GeneID:79802,Genbank:XM_024449814.1,HGNC:HGNC:25842 HHIP like 2 GO:0003824,GO:0005576 catalytic activity|extracellular region HHLA3 202.901565385285 188.212776313532 217.590354457038 1.15608705593167 0.209250040080797 0.360628299521912 1 2.39231 2.96072 3.25863 2.97958 GeneID:11147,Genbank:XM_011540547.3,HGNC:HGNC:4906,MIM:604372 HERV-H LTR-associating 3 GO:0005102,GO:0005783,GO:0005789,GO:0006621,GO:0010869,GO:0048471,GO:2000209 receptor binding|endoplasmic reticulum|endoplasmic reticulum membrane|protein retention in ER lumen|regulation of receptor biosynthetic process|perinuclear region of cytoplasm|regulation of anoikis HIBADH 1069.77120291922 1018.06089260305 1121.48151323539 1.10158588880465 0.13958198393742 0.352588705831203 1 18.1611 18.3054 21.7775 18.1522 GeneID:11112,Genbank:NM_152740.3,HGNC:HGNC:4907,MIM:608475 3-hydroxyisobutyrate dehydrogenase GO:0004616,GO:0005759,GO:0006574,GO:0008442,GO:0009083,GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity|mitochondrial matrix|valine catabolic process|3-hydroxyisobutyrate dehydrogenase activity|branched-chain amino acid catabolic process|NAD binding hsa00280 Valine, leucine and isoleucine degradation HIBCH 143.080047407998 147.566275916395 138.593818899601 0.939197103395918 -0.0905001358887032 0.747464479855851 1 2.44328 2.36478 2.29735 2.45533 GeneID:26275,Genbank:NM_198047.2,HGNC:HGNC:4908,MIM:610690 3-hydroxyisobutyryl-CoA hydrolase GO:0003860,GO:0005759,GO:0006574,GO:0009083,GO:0070062 3-hydroxyisobutyryl-CoA hydrolase activity|mitochondrial matrix|valine catabolic process|branched-chain amino acid catabolic process|extracellular exosome hsa00280,hsa00410,hsa00640 Valine, leucine and isoleucine degradation|beta-Alanine metabolism|Propanoate metabolism HIC1 27.5659575788431 25.5601481409368 29.5717670167494 1.15694818565576 0.210324254271371 0.744413130606191 1 0.523474 0.522545 0.804381 0.355013 GeneID:3090,Genbank:NM_006497.3,HGNC:HGNC:4909,MIM:603825 HIC ZBTB transcriptional repressor 1 HIC2 96.1412961157507 97.2918522694888 94.9907399620126 0.976348355450132 -0.0345321099961775 0.920397981290052 1 0.442031 0.479302 0.485389 0.44001 GeneID:23119,Genbank:XM_017028669.2,HGNC:HGNC:18595,MIM:607712 HIC ZBTB transcriptional repressor 2 GO:0003677,GO:0005634,GO:0006351,GO:0008022,GO:0045892,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|protein C-terminus binding|negative regulation of transcription, DNA-templated|metal ion binding HID1 253.612657578759 259.080007497755 248.145307659762 0.957794119493812 -0.0622125169070572 0.754995266732614 1 2.56723 2.7028 2.69257 2.43413 GeneID:283987,Genbank:XM_005257226.2,HGNC:HGNC:15736,MIM:605752 HID1 domain containing GO:0000138,GO:0005737,GO:0005794,GO:0005797,GO:0005829,GO:0005881,GO:0006886,GO:0031001,GO:0070062,GO:0090498 Golgi trans cisterna|cytoplasm|Golgi apparatus|Golgi medial cisterna|cytosol|cytoplasmic microtubule|intracellular protein transport|response to brefeldin A|extracellular exosome|extrinsic component of Golgi membrane HIF1A 3755.1266221442 3895.52564005601 3614.72760423239 0.927917805767649 -0.107931076671544 0.663749669674877 1 36.0452 29.9906 35.2505 26.6232 GeneID:3091,Genbank:NM_001530.3,HGNC:HGNC:4910,MIM:603348 hypoxia inducible factor 1 alpha subunit hsa04066,hsa04137,hsa04140,hsa04659,hsa04919,hsa05167,hsa05200,hsa05205,hsa05211,hsa05230,hsa05231 HIF-1 signaling pathway|Mitophagy - animal|Autophagy - animal|Th17 cell differentiation|Thyroid hormone signaling pathway|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|Renal cell carcinoma|Central carbon metabolism in cancer|Choline metabolism in cancer HIF1AN 1765.97656694655 1757.69968731454 1774.25344657855 1.00941785413258 0.0135235097207755 0.925097431715948 1 10.2701 10.0554 11.017 9.939 GeneID:55662,Genbank:NM_017902.2,HGNC:HGNC:17113,MIM:606615 hypoxia inducible factor 1 alpha subunit inhibitor GO:0005112,GO:0005506,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0008270,GO:0016706,GO:0019826,GO:0031406,GO:0036138,GO:0036139,GO:0036140,GO:0042264,GO:0042265,GO:0042803,GO:0045663,GO:0045746,GO:0048037,GO:0048471,GO:0051059,GO:0055114,GO:0061418,GO:0061428,GO:0071532,GO:0102113,GO:2001214 Notch binding|iron ion binding|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|zinc ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxygen sensor activity|carboxylic acid binding|peptidyl-histidine hydroxylation|peptidyl-histidine dioxygenase activity|peptidyl-asparagine 3-dioxygenase activity|peptidyl-aspartic acid hydroxylation|peptidyl-asparagine hydroxylation|protein homodimerization activity|positive regulation of myoblast differentiation|negative regulation of Notch signaling pathway|cofactor binding|perinuclear region of cytoplasm|NF-kappaB binding|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|ankyrin repeat binding|hypoxia-inducible factor-asparagine oxygenase activity|positive regulation of vasculogenesis HIGD1A 3449.94387492171 3690.90952911216 3208.97822073126 0.869427493527097 -0.201862376832852 0.134987941702287 1 52.7376 54.8278 44.8772 49.4822 GeneID:25994,Genbank:NM_014056.3,HGNC:HGNC:29527 HIG1 hypoxia inducible domain family member 1A GO:0005654,GO:0005739,GO:0005743,GO:0016021,GO:0043066,GO:0043234,GO:0055114,GO:0061418,GO:0070469 nucleoplasm|mitochondrion|mitochondrial inner membrane|integral component of membrane|negative regulation of apoptotic process|protein complex|oxidation-reduction process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|respiratory chain HIGD1B 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0 0.0208347 0 0 GeneID:51751,Genbank:XM_011524891.2,HGNC:HGNC:24318 HIG1 hypoxia inducible domain family member 1B GO:0016021 integral component of membrane HIGD2A 2395.96552453537 2363.09241185846 2428.83863721227 1.02782211352543 0.0395905970788973 0.795909746105049 1 150.806 160.075 156.95 167.725 GeneID:192286,Genbank:NM_138820.3,HGNC:HGNC:28311 HIG1 hypoxia inducible domain family member 2A GO:0005743,GO:0016021,GO:0043066,GO:0055114,GO:0070469 mitochondrial inner membrane|integral component of membrane|negative regulation of apoptotic process|oxidation-reduction process|respiratory chain HIKESHI 501.857037128746 517.170063536487 486.544010721005 0.940781466339995 -0.0880684559319988 0.600801494348904 1 7.89532 9.59051 7.9669 8.24193 GeneID:51501,Genbank:NM_016401.3,HGNC:HGNC:26938,MIM:614908 Hikeshi, heat shock protein nuclear import factor GO:0005622,GO:0005634,GO:0005654,GO:0005829,GO:0006606,GO:0007030,GO:0008565,GO:0015031,GO:0030324,GO:0030544,GO:0034605,GO:0070062,GO:1900034 intracellular|nucleus|nucleoplasm|cytosol|protein import into nucleus|Golgi organization|protein transporter activity|protein transport|lung development|Hsp70 protein binding|cellular response to heat|extracellular exosome|regulation of cellular response to heat HILPDA 316.611679052959 303.205033983279 330.01832412264 1.08843286599536 0.122252425548663 0.563439447985388 1 9.30816 11.1374 11.0948 11.4459 GeneID:29923,Genbank:NM_013332.3,HGNC:HGNC:28859,MIM:617905 hypoxia inducible lipid droplet associated GO:0001819,GO:0005102,GO:0005615,GO:0005654,GO:0005811,GO:0005829,GO:0006950,GO:0008284,GO:0009986,GO:0010884,GO:0016021,GO:0030141,GO:0034389,GO:0035425 positive regulation of cytokine production|receptor binding|extracellular space|nucleoplasm|lipid droplet|cytosol|response to stress|positive regulation of cell proliferation|cell surface|positive regulation of lipid storage|integral component of membrane|secretory granule|lipid particle organization|autocrine signaling HINFP 343.833441079651 328.581868679729 359.085013479574 1.09283270839748 0.128072569136565 0.504444193011297 1 2.71976 2.64194 2.50468 3.07752 GeneID:25988,Genbank:NM_001351958.1,HGNC:HGNC:17850,MIM:607099 histone H4 transcription factor GO:0000077,GO:0000082,GO:0000083,GO:0000978,GO:0001078,GO:0001701,GO:0003677,GO:0003682,GO:0003700,GO:0003713,GO:0005634,GO:0005654,GO:0006281,GO:0006351,GO:0006355,GO:0010468,GO:0010628,GO:0010629,GO:0015030,GO:0019899,GO:0042393,GO:0044212,GO:0045184,GO:0045445,GO:0045892,GO:0045893,GO:0046872 DNA damage checkpoint|G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|in utero embryonic development|DNA binding|chromatin binding|DNA binding transcription factor activity|transcription coactivator activity|nucleus|nucleoplasm|DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of gene expression|positive regulation of gene expression|negative regulation of gene expression|Cajal body|enzyme binding|histone binding|transcription regulatory region DNA binding|establishment of protein localization|myoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding HINT1 7523.08222045603 7820.91627672557 7225.24816418649 0.923836531237173 -0.114290499130519 0.655149508684458 1 505.695 595.245 450.076 585.565 GeneID:3094,Genbank:NM_005340.6,HGNC:HGNC:4912,MIM:601314 histidine triad nucleotide binding protein 1 GO:0000118,GO:0000166,GO:0005080,GO:0005634,GO:0005829,GO:0005856,GO:0005886,GO:0006351,GO:0006355,GO:0007165,GO:0009154,GO:0016787,GO:0050850,GO:0070062,GO:0072332 histone deacetylase complex|nucleotide binding|protein kinase C binding|nucleus|cytosol|cytoskeleton|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|signal transduction|purine ribonucleotide catabolic process|hydrolase activity|positive regulation of calcium-mediated signaling|extracellular exosome|intrinsic apoptotic signaling pathway by p53 class mediator HINT2 916.163333631913 884.919426753228 947.407240510598 1.07061412809824 0.0984385960644193 0.551526116725706 1 16.9123 19.4622 18.1236 19.0816 GeneID:84681,Genbank:XM_024447703.1,HGNC:HGNC:18344,MIM:609997 histidine triad nucleotide binding protein 2 GO:0000166,GO:0005730,GO:0005739,GO:0006694,GO:0006915,GO:0016787,GO:0044240,GO:2000757 nucleotide binding|nucleolus|mitochondrion|steroid biosynthetic process|apoptotic process|hydrolase activity|multicellular organismal lipid catabolic process|negative regulation of peptidyl-lysine acetylation HINT3 512.589924239153 498.316010542936 526.863837935371 1.05728860158704 0.0803692340971922 0.715518388361548 1 7.29705 7.05091 8.84955 6.31173 GeneID:135114,Genbank:NM_138571.4,HGNC:HGNC:18468,MIM:609998 histidine triad nucleotide binding protein 3 GO:0000166,GO:0005634,GO:0005737,GO:0016787,GO:0070062 nucleotide binding|nucleus|cytoplasm|hydrolase activity|extracellular exosome HIP1 2157.26346229453 2191.18524497762 2123.34167961144 0.969037959925259 -0.0453749137431172 0.734035754127623 1 8.18169 8.70051 9.24807 7.19824 GeneID:3092,Genbank:XM_011516116.2,HGNC:HGNC:4913,MIM:601767 huntingtin interacting protein 1 hsa05016 Huntington disease HIP1R 430.612873103337 385.334098757413 475.891647449262 1.23501047268817 0.304523275681389 0.121648768507667 1 2.28317 2.82316 3.08362 3.28138 GeneID:9026,Genbank:XM_011538963.1,HGNC:HGNC:18415,MIM:605613 huntingtin interacting protein 1 related GO:0005546,GO:0005547,GO:0005739,GO:0005829,GO:0005856,GO:0005905,GO:0005938,GO:0006898,GO:0006915,GO:0006919,GO:0014069,GO:0016324,GO:0017124,GO:0030100,GO:0030136,GO:0030276,GO:0030665,GO:0030837,GO:0032051,GO:0032092,GO:0032587,GO:0032839,GO:0032956,GO:0034316,GO:0035091,GO:0035615,GO:0042802,GO:0042803,GO:0043025,GO:0043065,GO:0043066,GO:0043197,GO:0043231,GO:0043325,GO:0045742,GO:0046982,GO:0048268,GO:0048471,GO:0050821,GO:0051015,GO:0055123,GO:0060453,GO:0061024,GO:0072583,GO:0080025,GO:0097060,GO:1901030,GO:1905445,GO:2000369,GO:2000588 phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|mitochondrion|cytosol|cytoskeleton|clathrin-coated pit|cell cortex|receptor-mediated endocytosis|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|postsynaptic density|apical plasma membrane|SH3 domain binding|regulation of endocytosis|clathrin-coated vesicle|clathrin binding|clathrin-coated vesicle membrane|negative regulation of actin filament polymerization|clathrin light chain binding|positive regulation of protein binding|ruffle membrane|dendrite cytoplasm|regulation of actin cytoskeleton organization|negative regulation of Arp2/3 complex-mediated actin nucleation|phosphatidylinositol binding|clathrin adaptor activity|identical protein binding|protein homodimerization activity|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|dendritic spine|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|positive regulation of epidermal growth factor receptor signaling pathway|protein heterodimerization activity|clathrin coat assembly|perinuclear region of cytoplasm|protein stabilization|actin filament binding|digestive system development|regulation of gastric acid secretion|membrane organization|clathrin-dependent endocytosis|phosphatidylinositol-3,5-bisphosphate binding|synaptic membrane|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of clathrin coat assembly|regulation of clathrin-dependent endocytosis|positive regulation of platelet-derived growth factor receptor-beta signaling pathway HIPK1 1317.99415844041 1412.66507937551 1223.3232375053 0.865968342649266 -0.207613809817254 0.261473684595512 1 7.06102 6.13321 6.43447 5.01391 GeneID:204851,Genbank:NM_198268.2,HGNC:HGNC:19006,MIM:608003 homeodomain interacting protein kinase 1 GO:0001654,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006351,GO:0006355,GO:0007224,GO:0008284,GO:0009952,GO:0010803,GO:0010842,GO:0016605,GO:0016607,GO:0030182,GO:0034333,GO:0042771,GO:0045766,GO:0048596,GO:0060059,GO:0060216,GO:0060235,GO:0061072,GO:0072577,GO:0097191,GO:1901796 eye development|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|smoothened signaling pathway|positive regulation of cell proliferation|anterior/posterior pattern specification|regulation of tumor necrosis factor-mediated signaling pathway|retina layer formation|PML body|nuclear speck|neuron differentiation|adherens junction assembly|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of angiogenesis|embryonic camera-type eye morphogenesis|embryonic retina morphogenesis in camera-type eye|definitive hemopoiesis|lens induction in camera-type eye|iris morphogenesis|endothelial cell apoptotic process|extrinsic apoptotic signaling pathway|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence HIPK2 6082.1543924519 5768.99109043954 6395.31769446427 1.10856778840631 0.148696993035534 0.600378428643038 1 13.5113 12.8065 18.1128 11.6446 GeneID:28996,Genbank:NM_001113239.2,HGNC:HGNC:14402,MIM:606868 homeodomain interacting protein kinase 2 hsa04218 Cellular senescence HIPK3 512.561178488401 648.053277475261 377.069079501542 0.581848888984188 -0.781283573059335 0.000288088601293868 0.0450711837493147 3.68029 3.14149 2.14116 1.70951 GeneID:10114,Genbank:NM_001278163.1,HGNC:HGNC:4915,MIM:604424 homeodomain interacting protein kinase 3 GO:0004672,GO:0004674,GO:0005524,GO:0005829,GO:0006355,GO:0006468,GO:0006915,GO:0009299,GO:0016604,GO:0016605,GO:0018105,GO:0018107,GO:0043066,GO:0043508 protein kinase activity|protein serine/threonine kinase activity|ATP binding|cytosol|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|mRNA transcription|nuclear body|PML body|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|negative regulation of apoptotic process|negative regulation of JUN kinase activity hsa04218 Cellular senescence HIPK4 1.21343236204623 0.490071401957362 1.93679332213509 3.95206354502522 1.98260614412799 0.683645161929023 1 0 0.0129566 0 0.0391887 GeneID:147746,Genbank:XM_006723036.3,HGNC:HGNC:19007,MIM:611712 homeodomain interacting protein kinase 4 GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0016572,GO:0018105,GO:0046777,GO:1901796 protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|histone phosphorylation|peptidyl-serine phosphorylation|protein autophosphorylation|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence HIRA 1255.34318861615 1282.10046605102 1228.58591118128 0.958260248485382 -0.0615105723181597 0.659840277294334 1 11.0647 12.0595 12.1645 10.588 GeneID:7290,Genbank:NM_003325.3,HGNC:HGNC:4916,MIM:600237 histone cell cycle regulator GO:0000790,GO:0001649,GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0006336,GO:0006351,GO:0006357,GO:0007369,GO:0009653,GO:0016569,GO:0016605,GO:0031491,GO:0031935,GO:0042692,GO:0043234,GO:0070062 nuclear chromatin|osteoblast differentiation|DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|DNA replication-independent nucleosome assembly|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|gastrulation|anatomical structure morphogenesis|covalent chromatin modification|PML body|nucleosome binding|regulation of chromatin silencing|muscle cell differentiation|protein complex|extracellular exosome HIRIP3 766.390003271194 739.918160705351 792.861845837038 1.07155343380303 0.0997037928614672 0.5538675436809 1 6.62308 7.58293 8.02699 7.35817 GeneID:8479,Genbank:NM_001197323.1,HGNC:HGNC:4917,MIM:603365 HIRA interacting protein 3 GO:0005634,GO:0005730,GO:0006333 nucleus|nucleolus|chromatin assembly or disassembly HIST1H1B 2.53259685265112 2.64246210852658 2.42273159677566 0.916846296095636 -0.125248200158545 1 1 0.325258 0.0713629 0.150323 0.208371 GeneID:3009,Genbank:NM_005322.2,HGNC:HGNC:4719,MIM:142711 histone cluster 1 H1 family member b GO:0000122,GO:0000786,GO:0000790,GO:0003723,GO:0005634,GO:0005720,GO:0006325,GO:0006334,GO:0030307,GO:0031490,GO:0042826,GO:0050821,GO:0051574,GO:0070062,GO:0071169 negative regulation of transcription from RNA polymerase II promoter|nucleosome|nuclear chromatin|RNA binding|nucleus|nuclear heterochromatin|chromatin organization|nucleosome assembly|positive regulation of cell growth|chromatin DNA binding|histone deacetylase binding|protein stabilization|positive regulation of histone H3-K9 methylation|extracellular exosome|establishment of protein localization to chromatin HIST1H1C 302.095063532469 279.979572992543 324.210554072395 1.15797931473033 0.211609482340522 0.298153233645258 1 19.6468 21.0297 24.3204 23.4267 GeneID:3006,Genbank:NM_005319.3,HGNC:HGNC:4716,MIM:142710 histone cluster 1 H1 family member c GO:0000122,GO:0000786,GO:0003723,GO:0005634,GO:0005719,GO:0006334,GO:0016584,GO:0031490,GO:0035327,GO:0080182,GO:0098532 negative regulation of transcription from RNA polymerase II promoter|nucleosome|RNA binding|nucleus|nuclear euchromatin|nucleosome assembly|nucleosome positioning|chromatin DNA binding|transcriptionally active chromatin|histone H3-K4 trimethylation|histone H3-K27 trimethylation HIST1H1D 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.136348 0 GeneID:3007,Genbank:NM_005320.2,HGNC:HGNC:4717,MIM:142210 histone cluster 1 H1 family member d GO:0000122,GO:0000786,GO:0000790,GO:0003723,GO:0005719,GO:0006334,GO:0016584,GO:0031490,GO:0080182,GO:0098532 negative regulation of transcription from RNA polymerase II promoter|nucleosome|nuclear chromatin|RNA binding|nuclear euchromatin|nucleosome assembly|nucleosome positioning|chromatin DNA binding|histone H3-K4 trimethylation|histone H3-K27 trimethylation HIST1H1E 2.96963888055335 2.54640955915669 3.39286820195 1.33241260807772 0.414040910824943 0.922281812887816 1 0.155909 0.134061 0.285778 0.19876 GeneID:3008,Genbank:NM_005321.2,HGNC:HGNC:4718,MIM:142220 histone cluster 1 H1 family member e GO:0000122,GO:0000788,GO:0003690,GO:0003723,GO:0005509,GO:0005524,GO:0005525,GO:0005634,GO:0005720,GO:0006334,GO:0016208,GO:0016584,GO:0031490,GO:0032564,GO:0043531,GO:0070062,GO:0080182,GO:0098532 negative regulation of transcription from RNA polymerase II promoter|nuclear nucleosome|double-stranded DNA binding|RNA binding|calcium ion binding|ATP binding|GTP binding|nucleus|nuclear heterochromatin|nucleosome assembly|AMP binding|nucleosome positioning|chromatin DNA binding|dATP binding|ADP binding|extracellular exosome|histone H3-K4 trimethylation|histone H3-K27 trimethylation HIST1H1T 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:3010,Genbank:NM_005323.3,HGNC:HGNC:4720,MIM:142712 histone cluster 1 H1 family member t GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0007275,GO:0007283,GO:0030154 nucleosome|DNA binding|nucleus|nucleosome assembly|multicellular organism development|spermatogenesis|cell differentiation HIST1H2AB 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.190294 0 0.176096 0 GeneID:8335,Genbank:NM_003513.2,HGNC:HGNC:4734,MIM:602795 histone cluster 1 H2A family member b GO:0000786,GO:0000790,GO:0003677,GO:0005634,GO:0006342,GO:0008285,GO:0046982,GO:0070062 nucleosome|nuclear chromatin|DNA binding|nucleus|chromatin silencing|negative regulation of cell proliferation|protein heterodimerization activity|extracellular exosome hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST1H2AC 75.2461696583871 57.9234609794839 92.5688783372903 1.59812408947866 0.67637943350056 0.0452880128667839 0.792169711191323 5.08944 7.31611 9.86624 8.10746 GeneID:8334,Genbank:NM_003512.3,HGNC:HGNC:4733,MIM:602794 histone cluster 1 H2A family member c GO:0000786,GO:0000790,GO:0003677,GO:0005634,GO:0006342,GO:0008285,GO:0046982,GO:0070062 nucleosome|nuclear chromatin|DNA binding|nucleus|chromatin silencing|negative regulation of cell proliferation|protein heterodimerization activity|extracellular exosome hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST1H2AE 4.16786771239249 4.4586688923012 3.87706653248377 0.869556952115981 -0.2016475741473 0.950110349846144 1 0.147188 0.90654 0.546743 0.510724 GeneID:3012,Genbank:NM_021052.2,HGNC:HGNC:4724,MIM:602786 histone cluster 1 H2A family member e GO:0000786,GO:0000790,GO:0003677,GO:0005634,GO:0006342,GO:0008285,GO:0046982,GO:0070062 nucleosome|nuclear chromatin|DNA binding|nucleus|chromatin silencing|negative regulation of cell proliferation|protein heterodimerization activity|extracellular exosome hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST1H2AG 10.2550308053192 10.3297170606816 10.1803445499568 0.985539535124986 -0.0210143484438521 1 1 1.09458 0.524171 0.987736 0.783974 GeneID:8969,Genbank:NM_021064.4,HGNC:HGNC:4737,MIM:615012 histone cluster 1 H2A family member g GO:0000786,GO:0000790,GO:0003677,GO:0006342,GO:0046982 nucleosome|nuclear chromatin|DNA binding|chromatin silencing|protein heterodimerization activity hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST1H2AH 0.995346334121811 0.538097676642304 1.45259499160132 2.69950058261805 1.43269252815597 0.83528100889094 1 0.187245 0 0 0 GeneID:85235,Genbank:NM_080596.2,HGNC:HGNC:13671,MIM:615013 histone cluster 1 H2A family member h GO:0000786,GO:0000790,GO:0003677,GO:0006342,GO:0046982 nucleosome|nuclear chromatin|DNA binding|chromatin silencing|protein heterodimerization activity hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST1H2AI 6.23527627248211 6.169014471598 6.30153807336622 1.02148213501174 0.0306639725925757 1 1 0.58101 0.657715 0.525096 0.160155 GeneID:8329,Genbank:NM_003509.2,HGNC:HGNC:4725,MIM:602787 histone cluster 1 H2A family member i GO:0000786,GO:0000790,GO:0003677,GO:0006342,GO:0046982 nucleosome|nuclear chromatin|DNA binding|chromatin silencing|protein heterodimerization activity hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST1H2AJ 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.182703 0 0 GeneID:8331,Genbank:NM_021066.2,HGNC:HGNC:4727,MIM:602791 histone cluster 1 H2A family member j GO:0000786,GO:0000790,GO:0003677,GO:0005634,GO:0006342,GO:0046982,GO:0070062 nucleosome|nuclear chromatin|DNA binding|nucleus|chromatin silencing|protein heterodimerization activity|extracellular exosome hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST1H2AK 4.34520426695187 6.26506702096788 2.42534151293585 0.387121399470865 -1.36914203510737 0.394450993645639 1 0.540212 0.306596 0.628938 0 GeneID:8330,Genbank:NM_003510.2,HGNC:HGNC:4726,MIM:602788 histone cluster 1 H2A family member k GO:0000786,GO:0000790,GO:0003677,GO:0006342,GO:0046982 nucleosome|nuclear chromatin|DNA binding|chromatin silencing|protein heterodimerization activity hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST1H2AL 3.54219087930521 5.6309167949557 1.45346496365472 0.258122259053226 -1.95387353795359 0.277353800702687 1 0.812807 0.862272 0.18666 0 GeneID:8332,Genbank:NM_003511.2,HGNC:HGNC:4730,MIM:602793 histone cluster 1 H2A family member l GO:0000786,GO:0000790,GO:0003677,GO:0006342,GO:0046982 nucleosome|nuclear chromatin|DNA binding|chromatin silencing|protein heterodimerization activity hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST1H2AM 5.16658556825279 5.48683797090087 4.84633316560471 0.883265223304746 -0.179081385334699 0.944409184002099 1 0.395687 1.35961 0.730633 0.168244 GeneID:8336,Genbank:NM_003514.2,HGNC:HGNC:4735,MIM:602796 histone cluster 1 H2A family member m GO:0000786,GO:0000790,GO:0003677,GO:0006342,GO:0046982 nucleosome|nuclear chromatin|DNA binding|chromatin silencing|protein heterodimerization activity hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST1H2BB 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0.155308 GeneID:3018,Genbank:NM_021062.2,HGNC:HGNC:4751,MIM:602803 histone cluster 1 H2B family member b GO:0000784,GO:0000786,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0046982 nuclear chromosome, telomeric region|nucleosome|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BC 14.2683560080361 9.15746915802711 19.3792428580451 2.11622256363899 1.08149136401764 0.165061110156818 1 0.940566 0.166642 0.876666 3.74625 GeneID:8347,Genbank:NM_003526.2,HGNC:HGNC:4757,MIM:602847 histone cluster 1 H2B family member c GO:0000786,GO:0003677,GO:0005654,GO:0006334,GO:0046982 nucleosome|DNA binding|nucleoplasm|nucleosome assembly|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BD 45.4640836226294 38.1000908379805 52.8280764072783 1.38656037939458 0.471510441589417 0.28579910512526 1 0.781779 1.03753 1.30514 0.937474 GeneID:3017,Genbank:XM_005249039.4,HGNC:HGNC:4747,MIM:602799 histone cluster 1 H2B family member d GO:0000786,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0046982 nucleosome|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BE 0.996216306175209 0.538097676642304 1.45433493570811 2.70273409241064 1.43441957978558 0.835201184388344 1 0.179197 0 0 0 GeneID:8344,Genbank:NM_003523.2,HGNC:HGNC:4753,MIM:602805 histone cluster 1 H2B family member e GO:0000786,GO:0003677,GO:0005654,GO:0006334,GO:0046982 nucleosome|DNA binding|nucleoplasm|nucleosome assembly|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BF 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0 0 0.170646 GeneID:8343,Genbank:NM_003522.3,HGNC:HGNC:4752,MIM:602804 histone cluster 1 H2B family member f GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BG 2.07741475883001 3.67063118712625 0.484198330533773 0.131911463137993 -2.92235815430287 0.305991428012652 1 0.801221 0.280459 0 0 GeneID:8339,Genbank:NM_003518.3,HGNC:HGNC:4746,MIM:602798 histone cluster 1 H2B family member g GO:0000786,GO:0003677,GO:0005654,GO:0006334,GO:0046982 nucleosome|DNA binding|nucleoplasm|nucleosome assembly|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BH 22.2810477881111 21.7934644044407 22.7686311717815 1.0447458352304 0.0631520075194574 0.985749389648212 1 1.72021 2.68316 0.87678 3.41261 GeneID:8345,Genbank:NM_003524.2,HGNC:HGNC:4755,MIM:602806 histone cluster 1 H2B family member h GO:0000786,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0019899,GO:0043234,GO:0044389,GO:0046982,GO:0070062,GO:0097677 nucleosome|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|enzyme binding|protein complex|ubiquitin-like protein ligase binding|protein heterodimerization activity|extracellular exosome|STAT family protein binding hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BI 1.48291618639408 1.02816907859967 1.93766329418849 1.88457651034159 0.91424036695755 0.868280404348966 1 0 0.160236 0.170103 0.473536 GeneID:8346,Genbank:NM_003525.2,HGNC:HGNC:4756,MIM:602807 histone cluster 1 H2B family member i GO:0000786,GO:0003677,GO:0005654,GO:0006334,GO:0046982 nucleosome|DNA binding|nucleoplasm|nucleosome assembly|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BJ 25.4854754169726 18.507043414794 32.4639074191511 1.75413796204749 0.810762219467053 0.151255676231735 1 1.66723 2.05747 2.1814 3.3263 GeneID:8970,Genbank:NM_021058.3,HGNC:HGNC:4761,MIM:615044 histone cluster 1 H2B family member j GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BK 437.296921670351 348.761040054243 525.832803286459 1.50771658211788 0.592365258844361 0.00103998000375325 0.1041019983757 15.267 15.4455 23.508 22.7535 GeneID:85236,Genbank:NM_080593.2,HGNC:HGNC:13954,MIM:615045 histone cluster 1 H2B family member k GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BL 2.2374683133291 1.56626675524197 2.90866987141623 1.85707183127108 0.893029619589079 0.765278089656887 1 0.330887 0.144099 0.305959 0.141885 GeneID:8340,Genbank:NM_003519.3,HGNC:HGNC:4748,MIM:602800 histone cluster 1 H2B family member l GO:0000786,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0046982,GO:0070062 nucleosome|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|protein heterodimerization activity|extracellular exosome hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BN 2.53509840233622 3.13253351048394 1.93766329418849 0.618561074511583 -0.693012046096525 0.83328892278546 1 0.528059 0.153061 0 0.300763 GeneID:8341,Genbank:NM_003520.3,HGNC:HGNC:4749,MIM:602801 histone cluster 1 H2B family member n GO:0000786,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0046982,GO:0070062 nucleosome|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|protein heterodimerization activity|extracellular exosome hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H2BO 5.37923351078032 4.4586688923012 6.29979812925943 1.41293248757209 0.498692532783051 0.790144744169533 1 0 1.06027 0.951771 1.03835 GeneID:8348,Genbank:NM_003527.4,HGNC:HGNC:4758,MIM:602808 histone cluster 1 H2B family member o GO:0000786,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0016567,GO:0046982 nucleosome|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein ubiquitination|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H3A 4.81039255951336 7.19718355019767 2.42360156882906 0.336743053991237 -1.57027990740542 0.283805544289589 1 0.221608 0.390787 0.616362 0.38235 GeneID:8350,Genbank:NM_003529.2,HGNC:HGNC:4766,MIM:602810 histone cluster 1 H3 family member a GO:0000183,GO:0000228,GO:0000786,GO:0000788,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0031492,GO:0032200,GO:0038111,GO:0043234,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0045815,GO:0046982,GO:0051290,GO:0060964,GO:0060968,GO:0070062,GO:1902036 chromatin silencing at rDNA|nuclear chromosome|nucleosome|nuclear nucleosome|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|nucleosomal DNA binding|telomere organization|interleukin-7-mediated signaling pathway|protein complex|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|protein heterotetramerization|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome|regulation of hematopoietic stem cell differentiation hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus HIST1H3B 4.0036810305766 5.58289052027075 2.42447154088245 0.434268150535912 -1.20334194626046 0.466298907044887 1 0.40561 0.698471 0.1877 0.174425 GeneID:8358,Genbank:NM_003537.3,HGNC:HGNC:4776,MIM:602819 histone cluster 1 H3 family member b GO:0000183,GO:0000228,GO:0000786,GO:0000788,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0031492,GO:0032200,GO:0038111,GO:0043234,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0045815,GO:0046982,GO:0051290,GO:0060964,GO:0060968,GO:0070062,GO:1902036 chromatin silencing at rDNA|nuclear chromosome|nucleosome|nuclear nucleosome|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|nucleosomal DNA binding|telomere organization|interleukin-7-mediated signaling pathway|protein complex|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|protein heterotetramerization|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome|regulation of hematopoietic stem cell differentiation hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus HIST1H3C 6.96320534591447 6.65908587355536 7.26732481827358 1.09133970581963 0.126100245215108 0.984074153442523 1 0.606503 0.872235 0.374231 0.866916 GeneID:8352,Genbank:NM_003531.2,HGNC:HGNC:4768,MIM:602812 histone cluster 1 H3 family member c GO:0000183,GO:0000228,GO:0000786,GO:0000788,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0031492,GO:0032200,GO:0038111,GO:0043234,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0045815,GO:0046982,GO:0051290,GO:0060964,GO:0060968,GO:0070062,GO:1902036 chromatin silencing at rDNA|nuclear chromosome|nucleosome|nuclear nucleosome|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|nucleosomal DNA binding|telomere organization|interleukin-7-mediated signaling pathway|protein complex|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|protein heterotetramerization|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome|regulation of hematopoietic stem cell differentiation hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus HIST1H3D 3.71994951369648 2.59443583384164 4.84546319355132 1.8676365514026 0.901213728866893 0.624660687507835 1 0.357028 0.121296 0.573244 0.610613 GeneID:8351,Genbank:NM_003530.4,HGNC:HGNC:4767,MIM:602811 histone cluster 1 H3 family member d GO:0000183,GO:0000228,GO:0000786,GO:0000788,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0031492,GO:0032200,GO:0038111,GO:0043234,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0045815,GO:0046982,GO:0051290,GO:0060964,GO:0060968,GO:0070062,GO:1902036 chromatin silencing at rDNA|nuclear chromosome|nucleosome|nuclear nucleosome|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|nucleosomal DNA binding|telomere organization|interleukin-7-mediated signaling pathway|protein complex|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|protein heterotetramerization|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome|regulation of hematopoietic stem cell differentiation hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus HIST1H3E 10.8466883023236 7.14915727551272 14.5442193291345 2.03439633073276 1.02460076507694 0.25843062883845 1 0 0.189572 0.609551 0.755658 GeneID:8353,Genbank:NM_003532.2,HGNC:HGNC:4769,MIM:602813 histone cluster 1 H3 family member e GO:0000183,GO:0000228,GO:0000786,GO:0000788,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0031492,GO:0032200,GO:0038111,GO:0043234,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0045815,GO:0046982,GO:0051290,GO:0060964,GO:0060968,GO:0070062,GO:1902036 chromatin silencing at rDNA|nuclear chromosome|nucleosome|nuclear nucleosome|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|nucleosomal DNA binding|telomere organization|interleukin-7-mediated signaling pathway|protein complex|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|protein heterotetramerization|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome|regulation of hematopoietic stem cell differentiation hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus HIST1H3F 1.48335117242078 1.02816907859967 1.93853326624189 1.88542264749112 0.914887962799843 0.868258168018795 1 0.199872 0.172328 0.370691 0 GeneID:8968,Genbank:NM_021018.2,HGNC:HGNC:4773,MIM:602816 histone cluster 1 H3 family member f GO:0000183,GO:0000228,GO:0000786,GO:0000788,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0031492,GO:0032200,GO:0038111,GO:0043234,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0045815,GO:0046982,GO:0051290,GO:0060964,GO:0060968,GO:0070062,GO:1902036 chromatin silencing at rDNA|nuclear chromosome|nucleosome|nuclear nucleosome|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|nucleosomal DNA binding|telomere organization|interleukin-7-mediated signaling pathway|protein complex|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|protein heterotetramerization|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome|regulation of hematopoietic stem cell differentiation hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus HIST1H3G 3.26726896956046 4.11267631439867 2.42186162472226 0.588877275909902 -0.763961092213934 0.730336338959084 1 0.412287 0.356234 0 0.352544 GeneID:8355,Genbank:NM_003534.2,HGNC:HGNC:4772,MIM:602815 histone cluster 1 H3 family member g GO:0000183,GO:0000228,GO:0000786,GO:0000788,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0031492,GO:0032200,GO:0038111,GO:0043234,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0045815,GO:0046982,GO:0051290,GO:0060964,GO:0060968,GO:0070062,GO:1902036 chromatin silencing at rDNA|nuclear chromosome|nucleosome|nuclear nucleosome|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|nucleosomal DNA binding|telomere organization|interleukin-7-mediated signaling pathway|protein complex|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|protein heterotetramerization|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome|regulation of hematopoietic stem cell differentiation hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus HIST1H3H 12.1744456671137 11.7519049918688 12.5969863423587 1.07191015848704 0.100183992235221 0.963476991089116 1 0.647796 1.10493 0.400733 2.03782 GeneID:8357,Genbank:NM_003536.2,HGNC:HGNC:4775,MIM:602818 histone cluster 1 H3 family member h GO:0000183,GO:0000228,GO:0000786,GO:0000788,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0031492,GO:0032200,GO:0038111,GO:0043234,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0045815,GO:0046982,GO:0051290,GO:0060964,GO:0060968,GO:0070062,GO:1902036 chromatin silencing at rDNA|nuclear chromosome|nucleosome|nuclear nucleosome|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|nucleosomal DNA binding|telomere organization|interleukin-7-mediated signaling pathway|protein complex|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|protein heterotetramerization|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome|regulation of hematopoietic stem cell differentiation hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus HIST1H3J 1.07619535328461 2.15239070656922 0 0 -Inf 0.475634333897108 1 0.597206 0 0 0 GeneID:8356,Genbank:NM_003535.2,HGNC:HGNC:4774,MIM:602817 histone cluster 1 H3 family member j GO:0000183,GO:0000228,GO:0000786,GO:0000788,GO:0005576,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006335,GO:0007596,GO:0016020,GO:0031492,GO:0032200,GO:0038111,GO:0043234,GO:0044267,GO:0045296,GO:0045652,GO:0045814,GO:0045815,GO:0046982,GO:0051290,GO:0060964,GO:0060968,GO:0070062,GO:1902036 chromatin silencing at rDNA|nuclear chromosome|nucleosome|nuclear nucleosome|extracellular region|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|DNA replication-dependent nucleosome assembly|blood coagulation|membrane|nucleosomal DNA binding|telomere organization|interleukin-7-mediated signaling pathway|protein complex|cellular protein metabolic process|cadherin binding|regulation of megakaryocyte differentiation|negative regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|protein heterodimerization activity|protein heterotetramerization|regulation of gene silencing by miRNA|regulation of gene silencing|extracellular exosome|regulation of hematopoietic stem cell differentiation hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus HIST1H4B 1.21136579838783 0 2.42273159677566 Inf Inf 0.33960385030001 1 0 0 0.465242 0.642976 GeneID:8366,Genbank:NM_003544.2,HGNC:HGNC:4789,MIM:602829 histone cluster 1 H4 family member b GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006352,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|DNA-templated transcription, initiation|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H4C 2.26061147861817 1.61429302992691 2.90692992730943 1.80074489167623 0.848593811681503 0.764093031048807 1 0.246724 0 0 0.418117 GeneID:8364,Genbank:NM_003542.3,HGNC:HGNC:4787,MIM:602827 histone cluster 1 H4 family member c GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006352,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|DNA-templated transcription, initiation|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H4D 3.20292843868485 1.07619535328461 5.32966152408509 4.95231791125901 2.3081039305205 0.232171562674284 1 0 0 0.500081 0.920132 GeneID:8360,Genbank:NM_003539.3,HGNC:HGNC:4782,MIM:602823 histone cluster 1 H4 family member d GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006352,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|DNA-templated transcription, initiation|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H4E 1.75490156042702 2.05633815719933 1.45346496365472 0.706821958521787 -0.500581234739772 0.969170192895383 1 0.251675 0 0 0 GeneID:8367,Genbank:NM_003545.3,HGNC:HGNC:4790,MIM:602830 histone cluster 1 H4 family member e GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006352,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|DNA-templated transcription, initiation|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H4F 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:8361,Genbank:NM_003540.3,HGNC:HGNC:4783,MIM:602824 histone cluster 1 H4 family member f GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006352,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|DNA-templated transcription, initiation|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H4H 2.75111786660223 2.59443583384164 2.90779989936283 1.12078312418973 0.164507138155569 1 1 0.468651 0.208429 0 0 GeneID:8365,Genbank:NM_003543.3,HGNC:HGNC:4788,MIM:602828 histone cluster 1 H4 family member h GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006352,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|DNA-templated transcription, initiation|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H4I 1.4647761204752 1.96028560782945 0.969266633120943 0.49445174175113 -1.01609837336455 0.813651560116793 1 0 0 0.229788 0 GeneID:8294,Genbank:NM_003495.2,HGNC:HGNC:4793,MIM:602833 histone cluster 1 H4 family member i GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006352,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|DNA-templated transcription, initiation|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H4J 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:8363,Genbank:NM_021968.3,HGNC:HGNC:4785,MIM:602826 histone cluster 1 H4 family member j GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006352,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|DNA-templated transcription, initiation|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST1H4K 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0 0 GeneID:8362,Genbank:NM_003541.2,HGNC:HGNC:4784,MIM:602825 histone cluster 1 H4 family member k GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006352,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|DNA-templated transcription, initiation|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST2H2AA3 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.257216 GeneID:8337,Genbank:NM_003516.2,HGNC:HGNC:4736,MIM:142720 histone cluster 2 H2A family member a3 GO:0000786,GO:0000790,GO:0003677,GO:0005634,GO:0006342,GO:0046982,GO:0070062 nucleosome|nuclear chromatin|DNA binding|nucleus|chromatin silencing|protein heterodimerization activity|extracellular exosome hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST2H2AA4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.139162 0 GeneID:723790,Genbank:NM_001040874.1,HGNC:HGNC:29668 histone cluster 2 H2A family member a4 GO:0000786,GO:0000790,GO:0003677,GO:0005634,GO:0006342,GO:0046982,GO:0070062 nucleosome|nuclear chromatin|DNA binding|nucleus|chromatin silencing|protein heterodimerization activity|extracellular exosome hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST2H2AB 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.185921 0 GeneID:317772,Genbank:NM_175065.2,HGNC:HGNC:20508,MIM:615014 histone cluster 2 H2A family member b GO:0000786,GO:0000790,GO:0003677,GO:0005634,GO:0006342,GO:0046982,GO:0070062 nucleosome|nuclear chromatin|DNA binding|nucleus|chromatin silencing|protein heterodimerization activity|extracellular exosome hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST2H2AC 8.95718367027517 12.0978975697713 5.81646977077905 0.480783519387081 -1.05654065163784 0.278202994454628 1 1.04712 1.76533 0.953452 0.5231 GeneID:8338,Genbank:NM_003517.2,HGNC:HGNC:4738,MIM:602797 histone cluster 2 H2A family member c GO:0000786,GO:0000790,GO:0003677,GO:0005634,GO:0006342,GO:0046982,GO:0070062 nucleosome|nuclear chromatin|DNA binding|nucleus|chromatin silencing|protein heterodimerization activity|extracellular exosome hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST2H2BE 38.600095209532 31.6429187182729 45.5572717007911 1.43973038980387 0.52579867159097 0.387423715963943 1 0.448867 1.19836 1.21829 1.11308 GeneID:8349,Genbank:NM_003528.2,HGNC:HGNC:4760,MIM:601831 histone cluster 2 H2B family member e GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST2H2BF 2.234966763644 1.07619535328461 3.3937381740034 3.15345923362846 1.65693528287698 0.507707039380725 1 0.0433934 0 0.204502 0.0762048 GeneID:440689,Genbank:NM_001161334.1,HGNC:HGNC:24700 histone cluster 2 H2B family member f GO:0000786,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0046982,GO:0070062 nucleosome|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein heterodimerization activity|extracellular exosome hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST2H3D 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0.191179 0 0 GeneID:653604,Genbank:NM_001123375.2,HGNC:HGNC:25311 histone cluster 2 H3 family member d GO:0000786,GO:0000788,GO:0005634,GO:0005700,GO:0006334,GO:0031492,GO:0035059,GO:0046982 nucleosome|nuclear nucleosome|nucleus|polytene chromosome|nucleosome assembly|nucleosomal DNA binding|RCAF complex|protein heterodimerization activity hsa05034,hsa05202,hsa05322 Alcoholism|Transcriptional misregulation in cancer|Systemic lupus erythematosus HIST2H3PS2 108.867846398109 108.207693281498 109.52799951472 1.01220159300307 0.0174966499748096 0.970483384862847 1 1.8766 1.94399 2.13522 1.88435 GeneID:440686,Genbank:NM_001355409.1,HGNC:HGNC:32060 histone cluster 2 H3 pseudogene 2 GO:0000786,GO:0000788,GO:0005634,GO:0005700,GO:0006334,GO:0031492,GO:0035059,GO:0046982 nucleosome|nuclear nucleosome|nucleus|polytene chromosome|nucleosome assembly|nucleosomal DNA binding|RCAF complex|protein heterodimerization activity HIST2H4A 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0 0 0 GeneID:8370,Genbank:NM_003548.2,HGNC:HGNC:4794,MIM:142750 histone cluster 2 H4 family member a GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006352,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|DNA-templated transcription, initiation|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST3H2A 130.259474212753 126.762762970977 133.75618545453 1.05516937560879 0.0774745986838294 0.782896577788806 1 14.1682 13.8759 16.4418 14.3749 GeneID:92815,Genbank:NM_033445.2,HGNC:HGNC:20507,MIM:615015 histone cluster 3 H2A GO:0000788,GO:0003677,GO:0006337,GO:0006342,GO:0046982,GO:0070062,GO:0070914 nuclear nucleosome|DNA binding|nucleosome disassembly|chromatin silencing|protein heterodimerization activity|extracellular exosome|UV-damage excision repair hsa04217,hsa05034,hsa05322 Necroptosis|Alcoholism|Systemic lupus erythematosus HIST3H2BB 3.23368461950431 2.10436443188427 4.36300480712434 2.07331236976746 1.05193749240702 0.593249475059897 1 0 0 0.75585 0.422029 GeneID:128312,Genbank:NM_175055.2,HGNC:HGNC:20514,MIM:615046 histone cluster 3 H2B family member b GO:0000786,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006334,GO:0046982 nucleosome|DNA binding|nucleus|nucleoplasm|cytosol|nucleosome assembly|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIST4H4 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0.191557 0.167216 0.177923 0 GeneID:121504,Genbank:NM_175054.2,HGNC:HGNC:20510,MIM:615069 histone cluster 4 H4 GO:0000786,GO:0003677,GO:0005634,GO:0006334,GO:0006352,GO:0046982 nucleosome|DNA binding|nucleus|nucleosome assembly|DNA-templated transcription, initiation|protein heterodimerization activity hsa05034,hsa05203,hsa05322 Alcoholism|Viral carcinogenesis|Systemic lupus erythematosus HIVEP1 153.788563844612 161.67248536868 145.904642320544 0.902470460498093 -0.148048384151112 0.651787087478703 1 0.451332 0.452081 0.529781 0.303122 GeneID:3096,Genbank:XM_017010801.1,HGNC:HGNC:4920,MIM:194540 human immunodeficiency virus type I enhancer binding protein 1 GO:0000980,GO:0001206,GO:0003677,GO:0005634,GO:0005654,GO:0005739,GO:0006366,GO:0007165,GO:0007275,GO:0016604,GO:0043565,GO:0044212,GO:0046872 RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding|DNA binding|nucleus|nucleoplasm|mitochondrion|transcription from RNA polymerase II promoter|signal transduction|multicellular organism development|nuclear body|sequence-specific DNA binding|transcription regulatory region DNA binding|metal ion binding HIVEP2 443.833677382012 438.796856842886 448.870497921137 1.02295741394031 0.0327460864557168 0.922772879666125 1 1.56649 1.20572 1.80939 1.03941 GeneID:3097,Genbank:NM_006734.3,HGNC:HGNC:4921,MIM:143054 human immunodeficiency virus type I enhancer binding protein 2 GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0006355,GO:0006366,GO:0007165,GO:0007275,GO:0043565,GO:0044212,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|signal transduction|multicellular organism development|sequence-specific DNA binding|transcription regulatory region DNA binding|metal ion binding HIVEP3 565.054892523023 486.421043727867 643.68874131818 1.32331598235355 0.404157590523702 0.163281981978242 1 0.706708 0.785036 1.2116 0.783168 GeneID:59269,Genbank:NM_001127714.2,HGNC:HGNC:13561,MIM:606649 human immunodeficiency virus type I enhancer binding protein 3 GO:0003700,GO:0005634,GO:0005737,GO:0006366,GO:0007165,GO:0007275,GO:0035914,GO:0043565,GO:0044212,GO:0045893,GO:0046872 DNA binding transcription factor activity|nucleus|cytoplasm|transcription from RNA polymerase II promoter|signal transduction|multicellular organism development|skeletal muscle cell differentiation|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|metal ion binding HJURP 2351.22441013939 2390.84011732298 2311.60870295579 0.966860429606682 -0.048620449287624 0.735762234479774 1 27.878 26.7263 26.187 26.6624 GeneID:55355,Genbank:NM_001282963.1,HGNC:HGNC:25444,MIM:612667 Holliday junction recognition protein GO:0000775,GO:0000777,GO:0003677,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0005829,GO:0007049,GO:0007059,GO:0034080,GO:0042393,GO:0042802,GO:0043254,GO:0051101 chromosome, centromeric region|condensed chromosome kinetochore|DNA binding|nucleus|nucleoplasm|nucleolus|mitochondrion|cytosol|cell cycle|chromosome segregation|CENP-A containing nucleosome assembly|histone binding|identical protein binding|regulation of protein complex assembly|regulation of DNA binding HK1 14164.3112861069 13431.6613136067 14896.9612586071 1.10909297895384 0.149380316493983 0.252008642673116 1 77.6102 79.7803 91.3863 87.1999 GeneID:3098,Genbank:XM_024447969.1,HGNC:HGNC:4922,MIM:142600 hexokinase 1 hsa00010,hsa00051,hsa00052,hsa00500,hsa00520,hsa00524,hsa04066,hsa04910,hsa04930,hsa04973,hsa05230 Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism|Neomycin, kanamycin and gentamicin biosynthesis|HIF-1 signaling pathway|Insulin signaling pathway|Type II diabetes mellitus|Carbohydrate digestion and absorption|Central carbon metabolism in cancer HK2 481.677593174509 526.740151856463 436.615034492555 0.828900232787899 -0.270729626850039 0.12398887532686 1 2.88135 2.87882 2.23665 2.54983 GeneID:3099,Genbank:NM_000189.4,HGNC:HGNC:4923,MIM:601125 hexokinase 2 hsa00010,hsa00051,hsa00052,hsa00500,hsa00520,hsa00524,hsa04066,hsa04910,hsa04930,hsa04973,hsa05230 Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism|Neomycin, kanamycin and gentamicin biosynthesis|HIF-1 signaling pathway|Insulin signaling pathway|Type II diabetes mellitus|Carbohydrate digestion and absorption|Central carbon metabolism in cancer HKDC1 180.715249595936 128.338838381326 233.091660810546 1.81622074619355 0.860939560604771 0.000315278127341925 0.0467545785880396 0.774368 0.81493 1.36184 1.52837 GeneID:80201,Genbank:NM_025130.3,HGNC:HGNC:23302,MIM:617221 hexokinase domain containing 1 GO:0001678,GO:0004340,GO:0005524,GO:0005536,GO:0005739,GO:0005829,GO:0006096,GO:0008865,GO:0019158,GO:0019318 cellular glucose homeostasis|glucokinase activity|ATP binding|glucose binding|mitochondrion|cytosol|glycolytic process|fructokinase activity|mannokinase activity|hexose metabolic process hsa00010,hsa00051,hsa00052,hsa00500,hsa00520,hsa00524,hsa04066,hsa04910,hsa04930,hsa04973,hsa05230 Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism|Neomycin, kanamycin and gentamicin biosynthesis|HIF-1 signaling pathway|Insulin signaling pathway|Type II diabetes mellitus|Carbohydrate digestion and absorption|Central carbon metabolism in cancer HKR1 445.132397342279 352.844290403317 537.42050428124 1.52310953839424 0.607019700732253 0.000649429256239622 0.0748292012081567 1.68377 1.4326 2.34746 2.53833 GeneID:284459,Genbank:NM_001329765.1,HGNC:HGNC:4928,MIM:165250 HKR1, GLI-Kruppel zinc finger family member GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0007275,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|metal ion binding HLA-A 5815.79188889912 5504.63836273499 6126.94541506325 1.11305139617184 0.154520211988281 0.275984003837876 1 111.6 128.678 134.915 138.765 GeneID:3105,Genbank:NM_002116.7,HGNC:HGNC:4931,MIM:142800 major histocompatibility complex, class I, A GO:0000139,GO:0002474,GO:0002479,GO:0002480,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0006955,GO:0009986,GO:0012507,GO:0016020,GO:0016032,GO:0016567,GO:0030670,GO:0030881,GO:0031901,GO:0042605,GO:0042612,GO:0046977,GO:0050776,GO:0055038,GO:0060333,GO:0060337,GO:0071556 Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|immune response|cell surface|ER to Golgi transport vesicle membrane|membrane|viral process|protein ubiquitination|phagocytic vesicle membrane|beta-2-microglobulin binding|early endosome membrane|peptide antigen binding|MHC class I protein complex|TAP binding|regulation of immune response|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|integral component of lumenal side of endoplasmic reticulum membrane hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416 Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules (CAMs)|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-B 731.77965565563 711.820394659511 751.73891665175 1.05607948619024 0.0787184237274918 0.632113671390869 1 22.2971 19.7706 26.5523 20.4987 GeneID:3106,Genbank:NM_005514.7,HGNC:HGNC:4932,MIM:142830 major histocompatibility complex, class I, B GO:0000139,GO:0002474,GO:0002479,GO:0002480,GO:0002667,GO:0005102,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006955,GO:0009986,GO:0012507,GO:0016020,GO:0016032,GO:0030667,GO:0030670,GO:0031901,GO:0032655,GO:0032675,GO:0042270,GO:0042605,GO:0042612,GO:0043312,GO:0050776,GO:0055038,GO:0060333,GO:0060337,GO:0070062,GO:0071556,GO:2001198 Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|regulation of T cell anergy|receptor binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|immune response|cell surface|ER to Golgi transport vesicle membrane|membrane|viral process|secretory granule membrane|phagocytic vesicle membrane|early endosome membrane|regulation of interleukin-12 production|regulation of interleukin-6 production|protection from natural killer cell mediated cytotoxicity|peptide antigen binding|MHC class I protein complex|neutrophil degranulation|regulation of immune response|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|extracellular exosome|integral component of lumenal side of endoplasmic reticulum membrane|regulation of dendritic cell differentiation hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416 Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules (CAMs)|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-C 1421.11651707455 1354.75549505455 1487.47753909455 1.09796752589267 0.134835385011212 0.521223096411914 1 30.3535 32.5153 40.2304 31.7011 GeneID:3107,Genbank:NM_002117.5,HGNC:HGNC:4933,MIM:142840 major histocompatibility complex, class I, C GO:0000139,GO:0002474,GO:0002479,GO:0002480,GO:0005783,GO:0005794,GO:0005886,GO:0009986,GO:0012507,GO:0016032,GO:0030667,GO:0030670,GO:0031901,GO:0042605,GO:0042612,GO:0043312,GO:0050776,GO:0055038,GO:0060333,GO:0060337,GO:0070062,GO:0071556 Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|endoplasmic reticulum|Golgi apparatus|plasma membrane|cell surface|ER to Golgi transport vesicle membrane|viral process|secretory granule membrane|phagocytic vesicle membrane|early endosome membrane|peptide antigen binding|MHC class I protein complex|neutrophil degranulation|regulation of immune response|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|extracellular exosome|integral component of lumenal side of endoplasmic reticulum membrane hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416 Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules (CAMs)|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DMA 11.7601214131327 10.4355782651594 13.084664561106 1.25385141375356 0.326366393321844 0.80880343495409 1 0.143385 0.471618 0.447531 0.332624 GeneID:3108,Genbank:NM_006120.3,HGNC:HGNC:4934,MIM:142855 major histocompatibility complex, class II, DM alpha GO:0002503,GO:0005765,GO:0006955,GO:0009986,GO:0016020,GO:0016021,GO:0019886,GO:0023026,GO:0031902,GO:0042613,GO:0043231,GO:0070062 peptide antigen assembly with MHC class II protein complex|lysosomal membrane|immune response|cell surface|membrane|integral component of membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|MHC class II protein complex binding|late endosome membrane|MHC class II protein complex|intracellular membrane-bounded organelle|extracellular exosome hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416 Phagosome|Cell adhesion molecules (CAMs)|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease (IBD)|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DMB 1.02229600717608 1.07619535328461 0.968396661067546 0.899833527539349 -0.152269972565186 1 1 0.0293184 0 0 0.0514008 GeneID:3109,Genbank:NM_002118.4,HGNC:HGNC:4935,MIM:142856 major histocompatibility complex, class II, DM beta GO:0002399,GO:0002503,GO:0005765,GO:0006955,GO:0016021,GO:0019886,GO:0023026,GO:0031902,GO:0042102,GO:0042613,GO:2001190 MHC class II protein complex assembly|peptide antigen assembly with MHC class II protein complex|lysosomal membrane|immune response|integral component of membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|MHC class II protein complex binding|late endosome membrane|positive regulation of T cell proliferation|MHC class II protein complex|positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416 Phagosome|Cell adhesion molecules (CAMs)|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease (IBD)|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DOA 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0114131 0 GeneID:3111,Genbank:NM_002119.3,HGNC:HGNC:4936,MIM:142930 major histocompatibility complex, class II, DO alpha GO:0002587,GO:0005765,GO:0005886,GO:0006955,GO:0010008,GO:0016021,GO:0019886,GO:0023026,GO:0032395,GO:0042613,GO:0045580 negative regulation of antigen processing and presentation of peptide antigen via MHC class II|lysosomal membrane|plasma membrane|immune response|endosome membrane|integral component of membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|MHC class II protein complex binding|MHC class II receptor activity|MHC class II protein complex|regulation of T cell differentiation hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416 Phagosome|Cell adhesion molecules (CAMs)|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease (IBD)|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DOB 1.48171959478908 0.538097676642304 2.42534151293585 4.50725141217823 2.17224792508914 0.604228439629313 1 0 0 0.0306329 0 GeneID:3112,Genbank:NM_002120.3,HGNC:HGNC:4937,MIM:600629 major histocompatibility complex, class II, DO beta GO:0002587,GO:0005764,GO:0005765,GO:0006955,GO:0010008,GO:0016021,GO:0019886,GO:0023026,GO:0032395,GO:0042613 negative regulation of antigen processing and presentation of peptide antigen via MHC class II|lysosome|lysosomal membrane|immune response|endosome membrane|integral component of membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|MHC class II protein complex binding|MHC class II receptor activity|MHC class II protein complex hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416 Phagosome|Cell adhesion molecules (CAMs)|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease (IBD)|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-DPB1 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0 0 0 0.00889271 GeneID:3115,Genbank:NM_002121.5,HGNC:HGNC:4940,MIM:142858 major histocompatibility complex, class II, DP beta 1 GO:0000139,GO:0005765,GO:0005886,GO:0009986,GO:0010008,GO:0012507,GO:0016020,GO:0019886,GO:0030658,GO:0030666,GO:0030669,GO:0031295,GO:0032588,GO:0032729,GO:0042102,GO:0042605,GO:0042613,GO:0050852,GO:0050870,GO:0060333,GO:0071556 Golgi membrane|lysosomal membrane|plasma membrane|cell surface|endosome membrane|ER to Golgi transport vesicle membrane|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|transport vesicle membrane|endocytic vesicle membrane|clathrin-coated endocytic vesicle membrane|T cell costimulation|trans-Golgi network membrane|positive regulation of interferon-gamma production|positive regulation of T cell proliferation|peptide antigen binding|MHC class II protein complex|T cell receptor signaling pathway|positive regulation of T cell activation|interferon-gamma-mediated signaling pathway|integral component of lumenal side of endoplasmic reticulum membrane hsa04145,hsa04514,hsa04612,hsa04640,hsa04658,hsa04659,hsa04672,hsa04940,hsa05140,hsa05145,hsa05150,hsa05152,hsa05164,hsa05166,hsa05168,hsa05169,hsa05310,hsa05320,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05416 Phagosome|Cell adhesion molecules (CAMs)|Antigen processing and presentation|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Intestinal immune network for IgA production|Type I diabetes mellitus|Leishmaniasis|Toxoplasmosis|Staphylococcus aureus infection|Tuberculosis|Influenza A|Human T-cell leukemia virus 1 infection|Herpes simplex infection|Epstein-Barr virus infection|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease (IBD)|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-E 4777.71357584294 4540.113612454 5015.31353923189 1.10466696812925 0.143611495548388 0.290168842067658 1 50.0216 51.7924 63.8994 52.132 GeneID:3133,Genbank:NM_005516.5,HGNC:HGNC:4962,MIM:143010 major histocompatibility complex, class I, E GO:0000139,GO:0001916,GO:0002250,GO:0002474,GO:0002476,GO:0002479,GO:0002480,GO:0002715,GO:0002717,GO:0005102,GO:0005886,GO:0009986,GO:0012507,GO:0019731,GO:0030670,GO:0030881,GO:0031901,GO:0032398,GO:0032736,GO:0032753,GO:0032759,GO:0032760,GO:0036037,GO:0042270,GO:0042288,GO:0042605,GO:0042608,GO:0042612,GO:0045087,GO:0046703,GO:0050776,GO:0050830,GO:0051024,GO:0055038,GO:0060333,GO:0060337,GO:0070062,GO:0071556,GO:2000566 Golgi membrane|positive regulation of T cell mediated cytotoxicity|adaptive immune response|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|regulation of natural killer cell mediated immunity|positive regulation of natural killer cell mediated immunity|receptor binding|plasma membrane|cell surface|ER to Golgi transport vesicle membrane|antibacterial humoral response|phagocytic vesicle membrane|beta-2-microglobulin binding|early endosome membrane|MHC class Ib protein complex|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of TRAIL production|positive regulation of tumor necrosis factor production|CD8-positive, alpha-beta T cell activation|protection from natural killer cell mediated cytotoxicity|MHC class I protein binding|peptide antigen binding|T cell receptor binding|MHC class I protein complex|innate immune response|natural killer cell lectin-like receptor binding|regulation of immune response|defense response to Gram-positive bacterium|positive regulation of immunoglobulin secretion|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|extracellular exosome|integral component of lumenal side of endoplasmic reticulum membrane|positive regulation of CD8-positive, alpha-beta T cell proliferation hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416 Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules (CAMs)|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLA-F 301.292040751217 319.031397669969 283.552683832466 0.888792406964893 -0.170081603183857 0.569684967531007 1 1.34734 1.93604 1.85733 1.18256 GeneID:3134,Genbank:NM_001098479.1,HGNC:HGNC:4963,MIM:143110 major histocompatibility complex, class I, F GO:0000139,GO:0002474,GO:0002479,GO:0002480,GO:0005102,GO:0005783,GO:0005886,GO:0009986,GO:0012507,GO:0016020,GO:0030670,GO:0031901,GO:0042605,GO:0042612,GO:0046978,GO:0046979,GO:0050776,GO:0055038,GO:0060333,GO:0060337,GO:0071556 Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|receptor binding|endoplasmic reticulum|plasma membrane|cell surface|ER to Golgi transport vesicle membrane|membrane|phagocytic vesicle membrane|early endosome membrane|peptide antigen binding|MHC class I protein complex|TAP1 binding|TAP2 binding|regulation of immune response|recycling endosome membrane|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|integral component of lumenal side of endoplasmic reticulum membrane hsa04144,hsa04145,hsa04218,hsa04514,hsa04612,hsa04650,hsa04940,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203,hsa05320,hsa05330,hsa05332,hsa05416 Endocytosis|Phagosome|Cellular senescence|Cell adhesion molecules (CAMs)|Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Type I diabetes mellitus|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Autoimmune thyroid disease|Allograft rejection|Graft-versus-host disease|Viral myocarditis HLCS 665.094648935112 621.19641991783 708.992877952395 1.1413344559297 0.190721620027905 0.233573044702553 1 2.07232 1.81402 2.23906 2.22194 GeneID:3141,Genbank:NM_001352515.1,HGNC:HGNC:4976,MIM:609018 holocarboxylase synthetase GO:0000785,GO:0004077,GO:0004078,GO:0004079,GO:0004080,GO:0005524,GO:0005652,GO:0005739,GO:0005829,GO:0006768,GO:0008283,GO:0009305,GO:0009374,GO:0016363,GO:0016570,GO:0018271,GO:0019899,GO:0042803,GO:0070781,GO:0071110 chromatin|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|ATP binding|nuclear lamina|mitochondrion|cytosol|biotin metabolic process|cell proliferation|protein biotinylation|biotin binding|nuclear matrix|histone modification|biotin-protein ligase activity|enzyme binding|protein homodimerization activity|response to biotin|histone biotinylation hsa00780 Biotin metabolism HLF 15.5687271936189 11.2618335899114 19.8756207973264 1.76486543142774 0.819558184168878 0.269115585409161 1 0.0664544 0.0861614 0.182816 0.103735 GeneID:3131,Genbank:XM_005257269.3,HGNC:HGNC:4977,MIM:142385 HLF, PAR bZIP transcription factor HLTF 491.981602428296 502.668818230759 481.294386625832 0.957478103216829 -0.062688600791505 0.776000244806484 1 3.17095 3.10247 3.60841 2.59275 GeneID:6596,Genbank:NM_001318935.1,HGNC:HGNC:11099,MIM:603257 helicase like transcription factor HLX 53.3898479652363 52.0043865364185 54.7753093940541 1.05328248330927 0.0748924094074574 0.896730862424782 1 1.09024 1.42573 1.80798 1.08748 GeneID:3142,Genbank:NM_021958.3,HGNC:HGNC:4978,MIM:142995 H2.0 like homeobox GO:0001889,GO:0005634,GO:0006351,GO:0006355,GO:0007275,GO:0007519,GO:0008284,GO:0030154,GO:0043565,GO:0045627,GO:0045629,GO:0046622,GO:0048484,GO:0048557 liver development|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|skeletal muscle tissue development|positive regulation of cell proliferation|cell differentiation|sequence-specific DNA binding|positive regulation of T-helper 1 cell differentiation|negative regulation of T-helper 2 cell differentiation|positive regulation of organ growth|enteric nervous system development|embryonic digestive tract morphogenesis HM13 4324.68279629477 4307.74841769133 4341.61717489821 1.00786228765538 0.0112985252570209 0.956504522182566 1 30.8579 35.2965 33.5755 34.3409 GeneID:81502,Genbank:NM_178580.2,HGNC:HGNC:16435,MIM:607106 histocompatibility minor 13 GO:0005765,GO:0005783,GO:0005789,GO:0005791,GO:0005886,GO:0008233,GO:0009986,GO:0016020,GO:0030660,GO:0031625,GO:0033619,GO:0036513,GO:0042500,GO:0042803,GO:0051289,GO:0071458,GO:0071556,GO:1904211 lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|plasma membrane|peptidase activity|cell surface|membrane|Golgi-associated vesicle membrane|ubiquitin protein ligase binding|membrane protein proteolysis|Derlin-1 retrotranslocation complex|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|protein homotetramerization|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane|membrane protein proteolysis involved in retrograde protein transport, ER to cytosol HMBOX1 382.94600207441 397.497605910375 368.394398238444 0.926783942244689 -0.109695047064265 0.757382901123852 1 0.928077 0.785237 1.0218 0.576764 GeneID:79618,Genbank:NM_001324393.1,HGNC:HGNC:26137 homeobox containing 1 GO:0000122,GO:0000784,GO:0001227,GO:0003691,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006278,GO:0006351,GO:0016604,GO:0032212,GO:0032403,GO:0035563,GO:0042162,GO:0042802,GO:0043565,GO:0045892,GO:0045893,GO:0051973 negative regulation of transcription from RNA polymerase II promoter|nuclear chromosome, telomeric region|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|double-stranded telomeric DNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|RNA-dependent DNA biosynthetic process|transcription, DNA-templated|nuclear body|positive regulation of telomere maintenance via telomerase|protein complex binding|positive regulation of chromatin binding|telomeric DNA binding|identical protein binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of telomerase activity HMBS 889.667036110837 937.595164134381 841.738908087294 0.897763704726885 -0.155592323504695 0.315223140222946 1 12.3322 12.6035 10.6141 11.6703 GeneID:3145,Genbank:XM_024448460.1,HGNC:HGNC:4982,MIM:609806 hydroxymethylbilane synthase GO:0004418,GO:0005737,GO:0005829,GO:0006782,GO:0006783,GO:0018160 hydroxymethylbilane synthase activity|cytoplasm|cytosol|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|peptidyl-pyrromethane cofactor linkage hsa00860 Porphyrin and chlorophyll metabolism HMCES 1221.88725643283 1196.90651135131 1246.86800151435 1.04174218260927 0.05899827387952 0.716725766894895 1 21.0359 23.125 22.7119 25.2465 GeneID:56941,Genbank:XM_005247637.3,HGNC:HGNC:24446 5-hydroxymethylcytosine (hmC) binding, ES cell-specific GO:0003677,GO:0008233 DNA binding|peptidase activity HMCN1 481.199326654249 388.936069358784 573.462583949715 1.47443919226918 0.560166325064511 0.245847438061658 1 0.692091 0.62014 1.31467 0.690005 GeneID:83872,Genbank:XM_011510041.3,HGNC:HGNC:19194,MIM:608548 hemicentin 1 GO:0005509,GO:0005604,GO:0005938,GO:0007049,GO:0007601,GO:0030054,GO:0032154,GO:0050896,GO:0051301,GO:0070062 calcium ion binding|basement membrane|cell cortex|cell cycle|visual perception|cell junction|cleavage furrow|response to stimulus|cell division|extracellular exosome HMCN2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:256158,Genbank:XM_011518466.2,HGNC:HGNC:21293 hemicentin 2 GO:0005509,GO:0005604,GO:0005938,GO:0006939,GO:0030054,GO:0030335,GO:0031012,GO:0032154,GO:0050896 calcium ion binding|basement membrane|cell cortex|smooth muscle contraction|cell junction|positive regulation of cell migration|extracellular matrix|cleavage furrow|response to stimulus HMG20A 1035.41253024201 997.804268988526 1073.0207914955 1.07538204119253 0.104849284017429 0.475536734381102 1 8.52325 7.76222 9.96416 8.22564 GeneID:10363,Genbank:NM_018200.3,HGNC:HGNC:5001,MIM:605534 high mobility group 20A GO:0000122,GO:0003677,GO:0003700,GO:0005634,GO:0006325,GO:0006351,GO:0006355,GO:0016569,GO:0033234,GO:0042802,GO:0045665,GO:0046982 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|nucleus|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|covalent chromatin modification|negative regulation of protein sumoylation|identical protein binding|negative regulation of neuron differentiation|protein heterodimerization activity HMG20B 2285.52013965788 1989.98067218466 2581.05960713109 1.29702747529579 0.375209040925884 0.00725488261238739 0.338869203906778 36.3312 36.0548 48.0623 48.6313 GeneID:10362,Genbank:XM_024451326.1,HGNC:HGNC:5002,MIM:605535 high mobility group 20B GO:0003677,GO:0004407,GO:0005654,GO:0005694,GO:0006351,GO:0006355,GO:0007049,GO:0007596,GO:0016604,GO:0033234,GO:0035914,GO:0045666,GO:0046982 DNA binding|histone deacetylase activity|nucleoplasm|chromosome|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|blood coagulation|nuclear body|negative regulation of protein sumoylation|skeletal muscle cell differentiation|positive regulation of neuron differentiation|protein heterodimerization activity HMGA1 8651.87235677664 10515.3848728497 6788.35984070354 0.645564563046169 -0.631366707908479 1.230530835771e-06 0.000856877472422101 160.518 172.43 106.445 110.023 GeneID:3159,Genbank:NM_001319082.1,HGNC:HGNC:5010,MIM:600701 high mobility group AT-hook 1 HMGA2 625.900952303284 720.122182527462 531.679722079107 0.738318767258403 -0.437684264168437 0.00865904512692166 0.362097302226572 4.49947 4.46072 3.76979 2.85611 GeneID:8091,Genbank:NM_003483.4,HGNC:HGNC:5009,MIM:600698 high mobility group AT-hook 2 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding hsa05202,hsa05206 Transcriptional misregulation in cancer|MicroRNAs in cancer HMGB1 6928.99233280105 7119.79353731054 6738.19112829156 0.946402601842422 -0.0794740549586051 0.558407863151046 1 44.881 44.0896 42.7673 41.8244 GeneID:3146,Genbank:NM_001313893.1,HGNC:HGNC:4983,MIM:163905 high mobility group box 1 GO:0003677,GO:0005634,GO:0005694 DNA binding|nucleus|chromosome hsa03410,hsa04140,hsa04217 Base excision repair|Autophagy - animal|Necroptosis HMGB2 5363.52935357006 5703.33234823321 5023.72635890692 0.880840542365232 -0.183047221667208 0.172196426365383 1 94.9323 93.1122 86.6072 80.7469 GeneID:3148,Genbank:NM_002129.3,HGNC:HGNC:5000,MIM:163906 high mobility group box 2 GO:0000400,GO:0000790,GO:0000793,GO:0001158,GO:0001938,GO:0002437,GO:0003677,GO:0003684,GO:0003690,GO:0003697,GO:0003700,GO:0003723,GO:0005615,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006265,GO:0006309,GO:0006325,GO:0006334,GO:0006351,GO:0006357,GO:0007289,GO:0008134,GO:0008144,GO:0008301,GO:0008584,GO:0019904,GO:0032075,GO:0032392,GO:0032496,GO:0032728,GO:0033151,GO:0042056,GO:0042493,GO:0043234,GO:0043388,GO:0044212,GO:0044378,GO:0045087,GO:0045089,GO:0045648,GO:0045654,GO:0045892,GO:0045893,GO:0045944,GO:0048471,GO:0048545,GO:0050767,GO:0050786,GO:0050829,GO:0050830,GO:0051103,GO:0060326,GO:0071222,GO:0072091,GO:0097100,GO:1902042 four-way junction DNA binding|nuclear chromatin|condensed chromosome|enhancer sequence-specific DNA binding|positive regulation of endothelial cell proliferation|inflammatory response to antigenic stimulus|DNA binding|damaged DNA binding|double-stranded DNA binding|single-stranded DNA binding|DNA binding transcription factor activity|RNA binding|extracellular space|cell|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA topological change|apoptotic DNA fragmentation|chromatin organization|nucleosome assembly|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|spermatid nucleus differentiation|transcription factor binding|drug binding|DNA binding, bending|male gonad development|protein domain specific binding|positive regulation of nuclease activity|DNA geometric change|response to lipopolysaccharide|positive regulation of interferon-beta production|V(D)J recombination|chemoattractant activity|response to drug|protein complex|positive regulation of DNA binding|transcription regulatory region DNA binding|non-sequence-specific DNA binding, bending|innate immune response|positive regulation of innate immune response|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|perinuclear region of cytoplasm|response to steroid hormone|regulation of neurogenesis|RAGE receptor binding|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|DNA ligation involved in DNA repair|cell chemotaxis|cellular response to lipopolysaccharide|regulation of stem cell proliferation|supercoiled DNA binding|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors HMGB3 3068.04280952502 3065.11610212966 3070.96951692039 1.00190968778855 0.00275246975894823 0.965474078417967 1 29.9412 28.5606 29.2537 30.1549 GeneID:3149,Genbank:NM_001301231.1,HGNC:HGNC:5004,MIM:300193 high mobility group box 3 GO:0000400,GO:0003690,GO:0003723,GO:0005634,GO:0005694,GO:0005737,GO:0006310,GO:0006351,GO:0006355,GO:0007275,GO:0008301,GO:0032392,GO:0045087,GO:0045578,GO:0045638 four-way junction DNA binding|double-stranded DNA binding|RNA binding|nucleus|chromosome|cytoplasm|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|DNA binding, bending|DNA geometric change|innate immune response|negative regulation of B cell differentiation|negative regulation of myeloid cell differentiation HMGCL 608.932916632181 554.000836921588 663.864996342773 1.19831045749257 0.261001729044633 0.232738914779308 1 12.8208 12.3962 13.1712 17.1521 GeneID:3155,Genbank:NM_001166059.1,HGNC:HGNC:5005,MIM:613898 3-hydroxymethyl-3-methylglutaryl-CoA lyase GO:0000062,GO:0000287,GO:0001889,GO:0004419,GO:0005102,GO:0005739,GO:0005743,GO:0005759,GO:0005777,GO:0006552,GO:0006629,GO:0006637,GO:0007005,GO:0007584,GO:0030145,GO:0031406,GO:0042594,GO:0042803,GO:0046872,GO:0046951,GO:0051262,GO:0070542 fatty-acyl-CoA binding|magnesium ion binding|liver development|hydroxymethylglutaryl-CoA lyase activity|receptor binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|peroxisome|leucine catabolic process|lipid metabolic process|acyl-CoA metabolic process|mitochondrion organization|response to nutrient|manganese ion binding|carboxylic acid binding|response to starvation|protein homodimerization activity|metal ion binding|ketone body biosynthetic process|protein tetramerization|response to fatty acid hsa00072,hsa00280,hsa00650,hsa04146 Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism|Peroxisome HMGCLL1 6.45042576469473 5.6309167949557 7.26993473443377 1.29107479281994 0.368572579347594 0.81391179950424 1 0.0232061 0.067015 0.0781134 0.0414519 GeneID:54511,Genbank:XM_024446471.1,HGNC:HGNC:21359 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 GO:0004419,GO:0005783,GO:0005789,GO:0005829,GO:0016020,GO:0046872,GO:0046951,GO:0048471 hydroxymethylglutaryl-CoA lyase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|membrane|metal ion binding|ketone body biosynthetic process|perinuclear region of cytoplasm hsa00072,hsa00280,hsa00650,hsa04146 Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism|Peroxisome HMGCR 1599.60905113138 1678.89424414878 1520.32385811399 0.905550700059022 -0.143132677703009 0.331943560153301 1 13.1103 12.1166 12.1271 11.0829 GeneID:3156,Genbank:XM_011543357.1,HGNC:HGNC:5006,MIM:142910 3-hydroxy-3-methylglutaryl-CoA reductase GO:0004420,GO:0005778,GO:0005783,GO:0005789,GO:0006695,GO:0006743,GO:0007568,GO:0007584,GO:0008299,GO:0008542,GO:0010664,GO:0010666,GO:0015936,GO:0016021,GO:0019216,GO:0032874,GO:0042282,GO:0042803,GO:0043407,GO:0045445,GO:0045471,GO:0045540,GO:0048643,GO:0048661,GO:0050662,GO:0051262,GO:0051721,GO:0061045,GO:0061179,GO:0070374,GO:0070402,GO:0097756 hydroxymethylglutaryl-CoA reductase (NADPH) activity|peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|ubiquinone metabolic process|aging|response to nutrient|isoprenoid biosynthetic process|visual learning|negative regulation of striated muscle cell apoptotic process|positive regulation of cardiac muscle cell apoptotic process|coenzyme A metabolic process|integral component of membrane|regulation of lipid metabolic process|positive regulation of stress-activated MAPK cascade|hydroxymethylglutaryl-CoA reductase activity|protein homodimerization activity|negative regulation of MAP kinase activity|myoblast differentiation|response to ethanol|regulation of cholesterol biosynthetic process|positive regulation of skeletal muscle tissue development|positive regulation of smooth muscle cell proliferation|coenzyme binding|protein tetramerization|protein phosphatase 2A binding|negative regulation of wound healing|negative regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of ERK1 and ERK2 cascade|NADPH binding|negative regulation of blood vessel diameter hsa00900,hsa04152,hsa04976 Terpenoid backbone biosynthesis|AMPK signaling pathway|Bile secretion HMGCS1 1188.80498312927 1150.8956004954 1226.71436576315 1.0658780563894 0.092042393532796 0.576835233280312 1 6.78854 6.39283 8.24602 6.09967 GeneID:3157,Genbank:NM_001324223.1,HGNC:HGNC:5007,MIM:142940 3-hydroxy-3-methylglutaryl-CoA synthase 1 GO:0001889,GO:0004421,GO:0005737,GO:0005829,GO:0006629,GO:0006695,GO:0007420,GO:0008144,GO:0008299,GO:0008584,GO:0009645,GO:0014074,GO:0016853,GO:0019216,GO:0033197,GO:0042493,GO:0042803,GO:0043177,GO:0045540,GO:0046690,GO:0071372,GO:0071397,GO:0071404 liver development|hydroxymethylglutaryl-CoA synthase activity|cytoplasm|cytosol|lipid metabolic process|cholesterol biosynthetic process|brain development|drug binding|isoprenoid biosynthetic process|male gonad development|response to low light intensity stimulus|response to purine-containing compound|isomerase activity|regulation of lipid metabolic process|response to vitamin E|response to drug|protein homodimerization activity|organic acid binding|regulation of cholesterol biosynthetic process|response to tellurium ion|cellular response to follicle-stimulating hormone stimulus|cellular response to cholesterol|cellular response to low-density lipoprotein particle stimulus hsa00072,hsa00280,hsa00650,hsa00900 Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism|Terpenoid backbone biosynthesis HMGN1 3266.21115101159 3473.49336543418 3058.928936589 0.880649137559714 -0.183360750344619 0.179352215374386 1 35.9163 37.6508 32.6575 32.1214 GeneID:3150,Genbank:NM_004965.6,HGNC:HGNC:4984,MIM:163920 high mobility group nucleosome binding domain 1 GO:0000720,GO:0000785,GO:0003677,GO:0005634,GO:0005654,GO:0005737,GO:0006283,GO:0006325,GO:0006357,GO:0010224,GO:0010225,GO:0031492,GO:0032786,GO:0040034,GO:0048597,GO:0050678,GO:1901666 pyrimidine dimer repair by nucleotide-excision repair|chromatin|DNA binding|nucleus|nucleoplasm|cytoplasm|transcription-coupled nucleotide-excision repair|chromatin organization|regulation of transcription from RNA polymerase II promoter|response to UV-B|response to UV-C|nucleosomal DNA binding|positive regulation of DNA-templated transcription, elongation|regulation of development, heterochronic|post-embryonic camera-type eye morphogenesis|regulation of epithelial cell proliferation|positive regulation of NAD+ ADP-ribosyltransferase activity hsa05168 Herpes simplex infection HMGN2 10449.7452807329 10018.5454728118 10880.9450886539 1.08608032155791 0.119130802247434 0.358853238093442 1 215.312 220.093 231.753 241.079 GeneID:3151,Genbank:NM_005517.3,HGNC:HGNC:4986,MIM:163910 high mobility group nucleosomal binding domain 2 HMGN3 1533.84986482369 1600.7533941752 1466.94633547217 0.916409948471809 -0.125934974379827 0.397663010531011 1 30.0956 28.6173 26.166 25.9892 GeneID:9324,Genbank:NM_001318885.1,HGNC:HGNC:12312,MIM:604502 high mobility group nucleosomal binding domain 3 GO:0000785,GO:0003682,GO:0005634,GO:0006357,GO:0016569,GO:0031492,GO:0045944,GO:0051091,GO:0061178 chromatin|chromatin binding|nucleus|regulation of transcription from RNA polymerase II promoter|covalent chromatin modification|nucleosomal DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of DNA binding transcription factor activity|regulation of insulin secretion involved in cellular response to glucose stimulus HMGN4 2110.54828039353 2166.72766715272 2054.36889363435 0.94814356449972 -0.076822571512421 0.594209612876535 1 36.7868 35.9702 36.3484 33.3739 GeneID:10473,Genbank:NM_006353.2,HGNC:HGNC:4989 high mobility group nucleosomal binding domain 4 HMGN5 16.0083695430224 12.6261865913057 19.3905524947392 1.53574100576745 0.618934934027738 0.460458099917451 1 0.206057 0.0623266 0.203702 0.132369 GeneID:79366,Genbank:NM_030763.2,HGNC:HGNC:8013,MIM:300385 high mobility group nucleosome binding domain 5 GO:0000785,GO:0003682,GO:0003723,GO:0005634,GO:0006351,GO:0006355,GO:0006357,GO:0008284,GO:0010628,GO:0016569,GO:0031492,GO:0043066,GO:0045893,GO:0071157 chromatin|chromatin binding|RNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|positive regulation of cell proliferation|positive regulation of gene expression|covalent chromatin modification|nucleosomal DNA binding|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|negative regulation of cell cycle arrest HMGXB3 2993.62100286725 2880.31827632303 3106.92372941147 1.07867375454692 0.109258586913321 0.428826681862949 1 19.0775 19.4098 21.3762 20.8259 GeneID:22993,Genbank:NM_014983.2,HGNC:HGNC:28982 HMG-box containing 3 GO:0003677,GO:0005634,GO:0016301 DNA binding|nucleus|kinase activity HMGXB4 732.205500688438 764.611801900249 699.799199476627 0.91523462983105 -0.12778645433101 0.441996960459664 1 5.45256 4.99915 4.93962 4.87443 GeneID:10042,Genbank:XM_006724100.4,HGNC:HGNC:5003,MIM:604702 HMG-box containing 4 GO:0003677,GO:0008333,GO:0016055,GO:0016589,GO:0030178 DNA binding|endosome to lysosome transport|Wnt signaling pathway|NURF complex|negative regulation of Wnt signaling pathway HMMR 394.182897958559 414.668705288244 373.697090628873 0.901194341080331 -0.150089840480661 0.582411901716111 1 4.59237 3.93355 4.70688 3.31126 GeneID:3161,Genbank:NM_001142556.1,HGNC:HGNC:5012,MIM:600936 hyaluronan mediated motility receptor GO:0005540,GO:0005813,GO:0005829,GO:0005886,GO:0009986,GO:0010389,GO:0015630,GO:0016020,GO:0030214 hyaluronic acid binding|centrosome|cytosol|plasma membrane|cell surface|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|membrane|hyaluronan catabolic process hsa04512 ECM-receptor interaction HMOX1 722.829807114035 809.420021887325 636.239592340746 0.786043803138482 -0.347318384426588 0.0692784319872879 0.918407228165493 21.6728 22.2715 15.3897 19.427 GeneID:3162,Genbank:NM_002133.2,HGNC:HGNC:5013,MIM:141250 heme oxygenase 1 hsa00860,hsa04066,hsa04216,hsa04978,hsa05200,hsa05206,hsa05225,hsa05418 Porphyrin and chlorophyll metabolism|HIF-1 signaling pathway|Ferroptosis|Mineral absorption|Pathways in cancer|MicroRNAs in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis HMOX2 951.396325175678 937.48051127565 965.312139075707 1.02968768680022 0.0422068218464262 0.804301288292421 1 11.1392 11.8995 11.069 12.6037 GeneID:3163,Genbank:XM_017023197.2,HGNC:HGNC:5014,MIM:141251 heme oxygenase 2 hsa00860,hsa04978 Porphyrin and chlorophyll metabolism|Mineral absorption HMX2 19.9216543627026 19.9772576206661 19.866051104739 0.994433344253818 -0.00805342281001302 1 1 0.683417 0.648677 0.557757 0.617885 GeneID:3167,Genbank:XM_005269743.3,HGNC:HGNC:5018,MIM:600647 H6 family homeobox 2 GO:0005634,GO:0006351,GO:0006355,GO:0007420,GO:0008284,GO:0030154,GO:0042472,GO:0043565,GO:0048026 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|brain development|positive regulation of cell proliferation|cell differentiation|inner ear morphogenesis|sequence-specific DNA binding|positive regulation of mRNA splicing, via spliceosome HMX3 7.41969239781568 5.6309167949557 9.20846800067565 1.63534080434732 0.709591324105995 0.546735945835679 1 0.350729 0.175415 0.254961 0.357335 GeneID:340784,Genbank:NM_001105574.1,HGNC:HGNC:5019,MIM:613380 H6 family homeobox 3 GO:0000977,GO:0005634,GO:0006351,GO:0006355,GO:0007420,GO:0007566,GO:0030154,GO:0042472,GO:0050885,GO:0060135 RNA polymerase II regulatory region sequence-specific DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|brain development|embryo implantation|cell differentiation|inner ear morphogenesis|neuromuscular process controlling balance|maternal process involved in female pregnancy HNF1A 4.75605822737813 6.12098819691306 3.3911282578432 0.554016467398748 -0.851999235794437 0.579336111238471 1 0.0213688 0.0457426 0.00974406 0.0274002 GeneID:6927,Genbank:XM_024449168.1,HGNC:HGNC:11621,MIM:142410 HNF1 homeobox A hsa04550,hsa04950 Signaling pathways regulating pluripotency of stem cells|Maturity onset diabetes of the young HNF4G 10.2246141502462 14.63449847382 5.81472982667226 0.39733031077726 -1.33158923969434 0.160108307321534 1 0.155151 0.0703802 0.0263797 0.0409495 GeneID:3174,Genbank:XM_017013373.1,HGNC:HGNC:5026,MIM:605966 hepatocyte nuclear factor 4 gamma hsa04950 Maturity onset diabetes of the young HNMT 482.335604607171 555.633730260876 409.037478953465 0.736163873207297 -0.441901142806699 0.0131603859960682 0.471274174870813 3.15556 2.90109 2.58025 2.13212 GeneID:3176,Genbank:XM_017003948.1,HGNC:HGNC:5028,MIM:605238 histamine N-methyltransferase GO:0001695,GO:0005737,GO:0005829,GO:0006548,GO:0007420,GO:0007585,GO:0032259,GO:0043005,GO:0046539,GO:0070062,GO:1903955 histamine catabolic process|cytoplasm|cytosol|histidine catabolic process|brain development|respiratory gaseous exchange|methylation|neuron projection|histamine N-methyltransferase activity|extracellular exosome|positive regulation of protein targeting to mitochondrion hsa00340 Histidine metabolism HNRNPA0 6306.92797077856 6424.29669674566 6189.55924481145 0.963460988336182 -0.053701843595605 0.676120480746919 1 136.251 141.037 135.369 134.108 GeneID:10949,Genbank:NM_006805.3,HGNC:HGNC:5030,MIM:609409 heterogeneous nuclear ribonucleoprotein A0 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0006397,GO:0006954,GO:0016070,GO:0017091,GO:0019901,GO:0030529,GO:0032496,GO:0070935 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|mRNA processing|inflammatory response|RNA metabolic process|AU-rich element binding|protein kinase binding|intracellular ribonucleoprotein complex|response to lipopolysaccharide|3'-UTR-mediated mRNA stabilization HNRNPA1 14566.8686221546 15516.4868263476 13617.2504179616 0.877598812821401 -0.18836652076184 0.150668951395651 1 224.863 218.281 204.905 189.739 GeneID:3178,Genbank:NM_031157.3,HGNC:HGNC:5031,MIM:164017 heterogeneous nuclear ribonucleoprotein A1 GO:0000380,GO:0000381,GO:0003697,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0008380,GO:0019904,GO:0030529,GO:0032211,GO:0032212,GO:0035198,GO:0036002,GO:0042149,GO:0051028,GO:0051168,GO:0051170,GO:0061752,GO:0071013,GO:0098505,GO:1903936 alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|single-stranded DNA binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|RNA splicing|protein domain specific binding|intracellular ribonucleoprotein complex|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|miRNA binding|pre-mRNA binding|cellular response to glucose starvation|mRNA transport|nuclear export|nuclear import|telomeric repeat-containing RNA binding|catalytic step 2 spliceosome|G-rich strand telomeric DNA binding|cellular response to sodium arsenite hsa03040 Spliceosome HNRNPA1L2 125.934845225051 141.377644134581 110.49204631552 0.781538318818925 -0.355611484599381 0.315736466019113 1 1.8119 1.2562 1.24768 1.32397 GeneID:144983,Genbank:NM_001011724.1,HGNC:HGNC:27067 heterogeneous nuclear ribonucleoprotein A1-like 2 GO:0003723,GO:0005681,GO:0005737,GO:0006397,GO:0008380,GO:0051028 RNA binding|spliceosomal complex|cytoplasm|mRNA processing|RNA splicing|mRNA transport hsa03040 Spliceosome HNRNPA2B1 20305.3865168144 21959.893551061 18650.8794825678 0.849315568820989 -0.235627398607975 0.0733548445859084 0.934750619674839 210.904 194.063 187.23 158.552 GeneID:3181,Genbank:XM_017012109.2,HGNC:HGNC:5033,MIM:600124 heterogeneous nuclear ribonucleoprotein A2/B1 GO:0000122,GO:0000398,GO:0003723,GO:0003730,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006397,GO:0006406,GO:0030529,GO:0031053,GO:0035198,GO:0042802,GO:0043047,GO:0048025,GO:0050658,GO:0070062,GO:0071013,GO:0097157,GO:1990247,GO:1990428 negative regulation of transcription from RNA polymerase II promoter|mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|mRNA processing|mRNA export from nucleus|intracellular ribonucleoprotein complex|primary miRNA processing|miRNA binding|identical protein binding|single-stranded telomeric DNA binding|negative regulation of mRNA splicing, via spliceosome|RNA transport|extracellular exosome|catalytic step 2 spliceosome|pre-mRNA intronic binding|N6-methyladenosine-containing RNA binding|miRNA transport HNRNPA3 6514.21482300479 7194.79880277107 5833.63084323851 0.810812227437367 -0.302560249385168 0.0233834322522063 0.616997337836357 52.0804 49.1343 43.3445 38.7937 GeneID:220988,Genbank:NM_194247.3,HGNC:HGNC:24941,MIM:605372 heterogeneous nuclear ribonucleoprotein A3 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0016070,GO:0030529,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|RNA metabolic process|intracellular ribonucleoprotein complex|catalytic step 2 spliceosome hsa03040 Spliceosome HNRNPAB 9562.83697554142 10038.2180064767 9087.45594460615 0.905285772708154 -0.143554813421798 0.267682555394332 1 214.931 216.596 196.836 199.647 GeneID:3182,Genbank:NM_031266.2,HGNC:HGNC:5034,MIM:602688 heterogeneous nuclear ribonucleoprotein A/B GO:0000122,GO:0001837,GO:0003677,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0030529,GO:0045893,GO:0090575 negative regulation of transcription from RNA polymerase II promoter|epithelial to mesenchymal transition|DNA binding|RNA binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|intracellular ribonucleoprotein complex|positive regulation of transcription, DNA-templated|RNA polymerase II transcription factor complex HNRNPC 16092.9645445155 16694.5210457494 15491.4080432815 0.927933661638393 -0.107906424713676 0.403296554913014 1 111.933 115.592 103.793 109.73 GeneID:3183,Genbank:NM_001077443.1,HGNC:HGNC:5035,MIM:164020 heterogeneous nuclear ribonucleoprotein C (C1/C2) GO:0000398,GO:0003730,GO:0005576,GO:0005654,GO:0005697,GO:0005829,GO:0008266,GO:0015629,GO:0032211,GO:0042802,GO:0043234,GO:0070034,GO:0070935,GO:0071013,GO:1990247 mRNA splicing, via spliceosome|mRNA 3'-UTR binding|extracellular region|nucleoplasm|telomerase holoenzyme complex|cytosol|poly(U) RNA binding|actin cytoskeleton|negative regulation of telomere maintenance via telomerase|identical protein binding|protein complex|telomerase RNA binding|3'-UTR-mediated mRNA stabilization|catalytic step 2 spliceosome|N6-methyladenosine-containing RNA binding hsa03040 Spliceosome HNRNPD 6354.99424829196 6478.06214478519 6231.92635179873 0.962004718774642 -0.0558841242433143 0.685815198566423 1 105.091 98.6284 104.639 95.251 GeneID:3184,Genbank:NM_001003810.1,HGNC:HGNC:5036,MIM:601324 heterogeneous nuclear ribonucleoprotein D HNRNPDL 3931.01338875318 4213.67498147315 3648.3517960332 0.865836072329836 -0.207834187745177 0.131154546368534 1 42.639 39.0217 37.5401 33.8385 GeneID:9987,Genbank:NM_001207000.1,HGNC:HGNC:5037,MIM:607137 heterogeneous nuclear ribonucleoprotein D like GO:0003677,GO:0003690,GO:0003697,GO:0003723,GO:0005634,GO:0005654,GO:0005681,GO:0005829,GO:0006351,GO:0006355,GO:0006396,GO:0008143,GO:0010468,GO:0034046,GO:0035722,GO:0070062 DNA binding|double-stranded DNA binding|single-stranded DNA binding|RNA binding|nucleus|nucleoplasm|spliceosomal complex|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA processing|poly(A) binding|regulation of gene expression|poly(G) binding|interleukin-12-mediated signaling pathway|extracellular exosome HNRNPF 8739.52816423734 9259.39987457136 8219.65645390331 0.887709415863609 -0.171840595000948 0.189165574908931 1 120.566 118.179 108.492 107.045 GeneID:3185,Genbank:NM_001098204.1,HGNC:HGNC:5039,MIM:601037 heterogeneous nuclear ribonucleoprotein F GO:0000398,GO:0003723,GO:0003727,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006396,GO:0008543,GO:0016020,GO:0016070,GO:0017025,GO:0035722,GO:0043484,GO:0071013 mRNA splicing, via spliceosome|RNA binding|single-stranded RNA binding|nucleus|nucleoplasm|cytosol|plasma membrane|RNA processing|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|TBP-class protein binding|interleukin-12-mediated signaling pathway|regulation of RNA splicing|catalytic step 2 spliceosome HNRNPH1 5100.31035176503 5576.43800474241 4624.18269878764 0.829235919928646 -0.270145484011022 0.142800562968448 1 41.7594 34.4492 35.8505 28.8854 GeneID:3187,Genbank:XM_011534546.1,HGNC:HGNC:5041,MIM:601035 heterogeneous nuclear ribonucleoprotein H1 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005829,GO:0006396,GO:0008266,GO:0008543,GO:0016020,GO:0016070,GO:0043484,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|cytosol|RNA processing|poly(U) RNA binding|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|regulation of RNA splicing|catalytic step 2 spliceosome HNRNPH2 1.45640149936651 0.490071401957362 2.42273159677566 4.94362982026534 2.30557071806793 0.554025919298353 1 2.7849 2.05766 2.9944 1.93085 GeneID:3188,Genbank:NM_019597.4,HGNC:HGNC:5042,MIM:300610 heterogeneous nuclear ribonucleoprotein H2 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005829,GO:0016020,GO:0016070,GO:0030529 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|cytosol|membrane|RNA metabolic process|intracellular ribonucleoprotein complex HNRNPH3 2164.65738709291 2287.47326912956 2041.84150505626 0.892618739030439 -0.163884001021649 0.255522798413484 1 26.0062 23.242 23.7939 21.1071 GeneID:3189,Genbank:NM_001322438.1,HGNC:HGNC:5043,MIM:602324 heterogeneous nuclear ribonucleoprotein H3 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005681,GO:0006396,GO:0008380,GO:0030855 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|spliceosomal complex|RNA processing|RNA splicing|epithelial cell differentiation HNRNPK 16439.2913020477 17150.0888811125 15728.4937229829 0.917108583635668 -0.124835539040158 0.33968903389104 1 190.378 183.732 178.038 172.38 GeneID:3190,Genbank:NM_031262.3,HGNC:HGNC:5044,MIM:600712 heterogeneous nuclear ribonucleoprotein K GO:0000122,GO:0000790,GO:0000978,GO:0000987,GO:0001077,GO:0001541,GO:0001822,GO:0001889,GO:0002102,GO:0003690,GO:0003697,GO:0003723,GO:0003730,GO:0005521,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0005925,GO:0005938,GO:0006357,GO:0006397,GO:0006953,GO:0007417,GO:0007422,GO:0007568,GO:0008134,GO:0008380,GO:0010629,GO:0010976,GO:0010988,GO:0014069,GO:0014823,GO:0016020,GO:0019904,GO:0021549,GO:0021766,GO:0021987,GO:0030324,GO:0030628,GO:0031012,GO:0031072,GO:0032091,GO:0032869,GO:0032993,GO:0033120,GO:0042802,GO:0042805,GO:0043010,GO:0043021,GO:0043066,GO:0043197,GO:0043679,GO:0045296,GO:0045716,GO:0045944,GO:0048025,GO:0048260,GO:0048538,GO:0050806,GO:0051117,GO:0060999,GO:0070062,GO:0071013,GO:0071230,GO:0071333,GO:0072369,GO:0072752,GO:0090129,GO:1900273,GO:1902074,GO:1902165,GO:1903861,GO:1904322,GO:1990715,GO:1990829,GO:2000010,GO:2000173 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|ovarian follicle development|kidney development|liver development|podosome|double-stranded DNA binding|single-stranded DNA binding|RNA binding|mRNA 3'-UTR binding|lamin binding|nucleus|nucleoplasm|mitochondrion|cytosol|focal adhesion|cell cortex|regulation of transcription from RNA polymerase II promoter|mRNA processing|acute-phase response|central nervous system development|peripheral nervous system development|aging|transcription factor binding|RNA splicing|negative regulation of gene expression|positive regulation of neuron projection development|regulation of low-density lipoprotein particle clearance|postsynaptic density|response to activity|membrane|protein domain specific binding|cerebellum development|hippocampus development|cerebral cortex development|lung development|pre-mRNA 3'-splice site binding|extracellular matrix|heat shock protein binding|negative regulation of protein binding|cellular response to insulin stimulus|protein-DNA complex|positive regulation of RNA splicing|identical protein binding|actinin binding|camera-type eye development|ribonucleoprotein complex binding|negative regulation of apoptotic process|dendritic spine|axon terminus|cadherin binding|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|negative regulation of mRNA splicing, via spliceosome|positive regulation of receptor-mediated endocytosis|thymus development|positive regulation of synaptic transmission|ATPase binding|positive regulation of dendritic spine development|extracellular exosome|catalytic step 2 spliceosome|cellular response to amino acid stimulus|cellular response to glucose stimulus|regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter|cellular response to rapamycin|positive regulation of synapse maturation|positive regulation of long-term synaptic potentiation|response to salt|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of dendrite extension|cellular response to forskolin|mRNA CDS binding|C-rich single-stranded DNA binding|positive regulation of protein localization to cell surface|negative regulation of branching morphogenesis of a nerve hsa03040,hsa05168,hsa05203,hsa05206 Spliceosome|Herpes simplex infection|Viral carcinogenesis|MicroRNAs in cancer HNRNPL 7691.009882728 7997.48264789827 7384.53711755772 0.923357691747961 -0.11503846527652 0.376381877281587 1 90.3016 90.1311 83.9034 86.9054 GeneID:3191,Genbank:XM_024451482.1,HGNC:HGNC:5045,MIM:603083 heterogeneous nuclear ribonucleoprotein L GO:0000381,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0006396,GO:0016020,GO:0016070,GO:0030529,GO:0035770,GO:0044212,GO:0070062,GO:0097157 regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|cytoplasm|RNA processing|membrane|RNA metabolic process|intracellular ribonucleoprotein complex|ribonucleoprotein granule|transcription regulatory region DNA binding|extracellular exosome|pre-mRNA intronic binding HNRNPLL 791.678679086497 791.941147551131 791.416210621864 0.999337151591517 -0.000956605188930265 0.989274985679834 1 7.87922 8.92835 8.86956 8.02107 GeneID:92906,Genbank:NM_001142650.1,HGNC:HGNC:25127,MIM:611208 heterogeneous nuclear ribonucleoprotein L like GO:0003723,GO:0003729,GO:0005634,GO:0006397,GO:0016020,GO:0030529,GO:0033120 RNA binding|mRNA binding|nucleus|mRNA processing|membrane|intracellular ribonucleoprotein complex|positive regulation of RNA splicing HNRNPM 6564.28635504092 6976.73395656113 6151.8387535207 0.881764847538055 -0.181534131307935 0.173624950106381 1 79.6813 75.0135 71.0681 68.0334 GeneID:4670,Genbank:XM_005272479.2,HGNC:HGNC:5046,MIM:160994 heterogeneous nuclear ribonucleoprotein M GO:0000380,GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0005730,GO:0005887,GO:0008543,GO:0016020,GO:0016070,GO:0016363,GO:0019904,GO:0031012,GO:0042382,GO:0070062,GO:0071013 alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|nucleolus|integral component of plasma membrane|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|nuclear matrix|protein domain specific binding|extracellular matrix|paraspeckles|extracellular exosome|catalytic step 2 spliceosome hsa03040 Spliceosome HNRNPR 4926.20837843331 5204.48398066532 4647.93277620129 0.893063134302724 -0.163165925894908 0.275427818348424 1 24.8611 23.2258 24.0557 19.4275 GeneID:10236,Genbank:NM_001297622.1,HGNC:HGNC:5047,MIM:607201 heterogeneous nuclear ribonucleoprotein R GO:0000398,GO:0003723,GO:0003730,GO:0005654,GO:0005681,GO:0005783,GO:0006397,GO:0007623,GO:0016070,GO:0030425,GO:0030426,GO:0030529,GO:0043086,GO:0043679,GO:0061157,GO:0071013 mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|nucleoplasm|spliceosomal complex|endoplasmic reticulum|mRNA processing|circadian rhythm|RNA metabolic process|dendrite|growth cone|intracellular ribonucleoprotein complex|negative regulation of catalytic activity|axon terminus|mRNA destabilization|catalytic step 2 spliceosome HNRNPU 13882.934570631 14269.7949457505 13496.0741955115 0.945779126246704 -0.0804247936421653 0.55105665968934 1 73.7245 71.2233 74.704 64.3114 GeneID:3192,Genbank:NM_004501.3,HGNC:HGNC:5048,MIM:602869 heterogeneous nuclear ribonucleoprotein U GO:0000122,GO:0000228,GO:0000381,GO:0000398,GO:0000776,GO:0000777,GO:0000922,GO:0000993,GO:0001047,GO:0001097,GO:0001649,GO:0003677,GO:0003682,GO:0003690,GO:0003697,GO:0003714,GO:0003723,GO:0003725,GO:0003727,GO:0003730,GO:0003779,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0006351,GO:0006396,GO:0007049,GO:0007346,GO:0008143,GO:0009048,GO:0009986,GO:0016020,GO:0016070,GO:0016363,GO:0016569,GO:0016607,GO:0017069,GO:0017130,GO:0030496,GO:0030529,GO:0031012,GO:0031490,GO:0032211,GO:0032922,GO:0032991,GO:0033673,GO:0034046,GO:0034244,GO:0036002,GO:0036464,GO:0042802,GO:0043021,GO:0044877,GO:0045944,GO:0048255,GO:0051301,GO:0051457,GO:0055013,GO:0070034,GO:0070934,GO:0070937,GO:0071013,GO:0071385,GO:0072686,GO:0098577,GO:0099122,GO:1901673,GO:1902275,GO:1902425,GO:1902889,GO:1990023,GO:1990280,GO:1990498,GO:1990830,GO:1990837,GO:1990841,GO:1990904,GO:2000373,GO:2000648,GO:2000737 negative regulation of transcription from RNA polymerase II promoter|nuclear chromosome|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|kinetochore|condensed chromosome kinetochore|spindle pole|RNA polymerase II core binding|core promoter binding|TFIIH-class transcription factor binding|osteoblast differentiation|DNA binding|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|transcription corepressor activity|RNA binding|double-stranded RNA binding|single-stranded RNA binding|mRNA 3'-UTR binding|actin binding|ATP binding|nucleus|nucleoplasm|centrosome|transcription, DNA-templated|RNA processing|cell cycle|regulation of mitotic cell cycle|poly(A) binding|dosage compensation by inactivation of X chromosome|cell surface|membrane|RNA metabolic process|nuclear matrix|covalent chromatin modification|nuclear speck|snRNA binding|poly(C) RNA binding|midbody|intracellular ribonucleoprotein complex|extracellular matrix|chromatin DNA binding|negative regulation of telomere maintenance via telomerase|circadian regulation of gene expression|macromolecular complex|negative regulation of kinase activity|poly(G) binding|negative regulation of transcription elongation from RNA polymerase II promoter|pre-mRNA binding|cytoplasmic ribonucleoprotein granule|identical protein binding|ribonucleoprotein complex binding|macromolecular complex binding|positive regulation of transcription from RNA polymerase II promoter|mRNA stabilization|cell division|maintenance of protein location in nucleus|cardiac muscle cell development|telomerase RNA binding|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|catalytic step 2 spliceosome|cellular response to glucocorticoid stimulus|mitotic spindle|inactive sex chromosome|RNA polymerase II C-terminal domain binding|regulation of mitotic spindle assembly|regulation of chromatin organization|positive regulation of attachment of mitotic spindle microtubules to kinetochore|protein localization to spindle microtubule|mitotic spindle midzone|RNA localization to chromatin|mitotic spindle microtubule|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding|promoter-specific chromatin binding|ribonucleoprotein complex|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|positive regulation of stem cell proliferation|negative regulation of stem cell differentiation hsa03040 Spliceosome HNRNPUL1 14070.1370874252 13789.723901643 14350.5502732074 1.04066987675493 0.0575124867912845 0.663183865350872 1 85.425 85.7549 91.4869 90.9759 GeneID:11100,Genbank:NM_144732.4,HGNC:HGNC:17011,MIM:605800 heterogeneous nuclear ribonucleoprotein U like 1 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0006396,GO:0009615,GO:0019899,GO:0030529 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA processing|response to virus|enzyme binding|intracellular ribonucleoprotein complex hsa05164 Influenza A HNRNPUL2 7665.55052820008 7444.8079463585 7886.29311004166 1.05930108162147 0.0831127000259282 0.531216859104632 1 47.6595 49.7831 52.8318 51.312 GeneID:221092,Genbank:NM_001079559.2,HGNC:HGNC:25451 heterogeneous nuclear ribonucleoprotein U like 2 GO:0003723,GO:0005634,GO:0005654,GO:0016020 RNA binding|nucleus|nucleoplasm|membrane HOGA1 38.315823651686 35.447820074346 41.183827229026 1.16181551200186 0.216380997269935 0.653801443547094 1 0.652293 0.508521 0.534792 0.926872 GeneID:112817,Genbank:NM_138413.3,HGNC:HGNC:25155,MIM:613597 4-hydroxy-2-oxoglutarate aldolase 1 GO:0005739,GO:0005759,GO:0008700,GO:0009436,GO:0019470,GO:0033609,GO:0042803,GO:0042866,GO:0046487,GO:0070062 mitochondrion|mitochondrial matrix|4-hydroxy-2-oxoglutarate aldolase activity|glyoxylate catabolic process|4-hydroxyproline catabolic process|oxalate metabolic process|protein homodimerization activity|pyruvate biosynthetic process|glyoxylate metabolic process|extracellular exosome hsa00330,hsa00630 Arginine and proline metabolism|Glyoxylate and dicarboxylate metabolism HOMER1 259.750161781954 311.593065745492 207.907257818416 0.667239681091727 -0.583723005727174 0.00533083690169456 0.285941071095182 1.83312 1.77617 1.19805 1.175 GeneID:9456,Genbank:NM_001277077.1,HGNC:HGNC:17512,MIM:604798 homer scaffold protein 1 GO:0003009,GO:0005102,GO:0005737,GO:0005829,GO:0005886,GO:0007216,GO:0007623,GO:0014069,GO:0016020,GO:0030018,GO:0030054,GO:0030424,GO:0030425,GO:0031802,GO:0032947,GO:0035094,GO:0035256,GO:0035418,GO:0042220,GO:0042802,GO:0043005,GO:0043025,GO:0043034,GO:0043198,GO:0044325,GO:0045177,GO:0045202,GO:0045211,GO:0046982,GO:0048148,GO:0048741,GO:0048875,GO:0051592,GO:0051928,GO:0090279,GO:0097110,GO:0098794,GO:2001256,GO:2001257 skeletal muscle contraction|receptor binding|cytoplasm|cytosol|plasma membrane|G-protein coupled glutamate receptor signaling pathway|circadian rhythm|postsynaptic density|membrane|Z disc|cell junction|axon|dendrite|type 5 metabotropic glutamate receptor binding|protein complex scaffold activity|response to nicotine|G-protein coupled glutamate receptor binding|protein localization to synapse|response to cocaine|identical protein binding|neuron projection|neuronal cell body|costamere|dendritic shaft|ion channel binding|apical part of cell|synapse|postsynaptic membrane|protein heterodimerization activity|behavioral response to cocaine|skeletal muscle fiber development|chemical homeostasis within a tissue|response to calcium ion|positive regulation of calcium ion transport|regulation of calcium ion import|scaffold protein binding|postsynapse|regulation of store-operated calcium entry|regulation of cation channel activity hsa04068,hsa04724 FoxO signaling pathway|Glutamatergic synapse HOMER2 390.425248719318 372.312876312665 408.53762112597 1.09729651354546 0.133953426214043 0.474898124319777 1 1.03371 1.04404 1.19044 1.12454 GeneID:9455,Genbank:XM_011522232.2,HGNC:HGNC:17513,MIM:604799 homer scaffold protein 2 GO:0003779,GO:0005737,GO:0005829,GO:0007216,GO:0007605,GO:0008277,GO:0014069,GO:0019904,GO:0030054,GO:0030160,GO:0030425,GO:0032426,GO:0035256,GO:0035584,GO:0042803,GO:0043025,GO:0045177,GO:0045211,GO:0046982,GO:0048148,GO:0048875 actin binding|cytoplasm|cytosol|G-protein coupled glutamate receptor signaling pathway|sensory perception of sound|regulation of G-protein coupled receptor protein signaling pathway|postsynaptic density|protein domain specific binding|cell junction|GKAP/Homer scaffold activity|dendrite|stereocilium tip|G-protein coupled glutamate receptor binding|calcium-mediated signaling using intracellular calcium source|protein homodimerization activity|neuronal cell body|apical part of cell|postsynaptic membrane|protein heterodimerization activity|behavioral response to cocaine|chemical homeostasis within a tissue hsa04068,hsa04724 FoxO signaling pathway|Glutamatergic synapse HOMER3 3798.06568881083 3292.117247787 4304.01412983467 1.30736963658505 0.386667096354578 0.00447251679220231 0.264386940078859 58.463 59.61 82.7045 76.7925 GeneID:9454,Genbank:NM_004838.3,HGNC:HGNC:17514,MIM:604800 homer scaffold protein 3 GO:0005829,GO:0006605,GO:0007216,GO:0008022,GO:0014069,GO:0019904,GO:0030054,GO:0035256,GO:0042802,GO:0045178,GO:0045211 cytosol|protein targeting|G-protein coupled glutamate receptor signaling pathway|protein C-terminus binding|postsynaptic density|protein domain specific binding|cell junction|G-protein coupled glutamate receptor binding|identical protein binding|basal part of cell|postsynaptic membrane hsa04068,hsa04724 FoxO signaling pathway|Glutamatergic synapse HOMEZ 124.442217024006 116.586933389458 132.297500658555 1.13475409990085 0.182379700786001 0.521705946279633 1 1.12486 1.19983 1.32688 1.36646 GeneID:57594,Genbank:NM_020834.2,HGNC:HGNC:20164,MIM:608119 homeobox and leucine zipper encoding GO:0000122,GO:0003677,GO:0003700,GO:0003714,GO:0005634,GO:0005730,GO:0005829,GO:0006351 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleolus|cytosol|transcription, DNA-templated HOOK1 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.00574951 0 0.0052737 GeneID:51361,Genbank:NM_015888.4,HGNC:HGNC:19884,MIM:607820 hook microtubule tethering protein 1 GO:0003779,GO:0005813,GO:0005829,GO:0005874,GO:0007032,GO:0007040,GO:0007275,GO:0007286,GO:0008017,GO:0008333,GO:0015031,GO:0030705,GO:0031122,GO:0042802,GO:0045022,GO:0051959,GO:0070695 actin binding|centrosome|cytosol|microtubule|endosome organization|lysosome organization|multicellular organism development|spermatid development|microtubule binding|endosome to lysosome transport|protein transport|cytoskeleton-dependent intracellular transport|cytoplasmic microtubule organization|identical protein binding|early endosome to late endosome transport|dynein light intermediate chain binding|FHF complex HOOK2 300.915134486519 293.633928662448 308.196340310591 1.04959376361743 0.0698310530174381 0.738708998938771 1 1.7777 1.86865 1.81513 2.21737 GeneID:29911,Genbank:XM_011527945.2,HGNC:HGNC:19885,MIM:607824 hook microtubule tethering protein 2 GO:0005813,GO:0005829,GO:0005874,GO:0006897,GO:0007032,GO:0007040,GO:0008017,GO:0008333,GO:0015031,GO:0030705,GO:0031122,GO:0042802,GO:0043231,GO:0045022,GO:0051959,GO:0070695 centrosome|cytosol|microtubule|endocytosis|endosome organization|lysosome organization|microtubule binding|endosome to lysosome transport|protein transport|cytoskeleton-dependent intracellular transport|cytoplasmic microtubule organization|identical protein binding|intracellular membrane-bounded organelle|early endosome to late endosome transport|dynein light intermediate chain binding|FHF complex HOOK3 413.702377371925 435.750567226664 391.654187517186 0.898803620635242 -0.153922158774095 0.704647247314774 1 1.48676 1.12809 1.46407 0.900674 GeneID:84376,Genbank:NM_032410.3,HGNC:HGNC:23576,MIM:607825 hook microtubule tethering protein 3 GO:0000242,GO:0005794,GO:0005801,GO:0005813,GO:0005829,GO:0005874,GO:0007032,GO:0007040,GO:0008017,GO:0008333,GO:0015031,GO:0022027,GO:0030705,GO:0031122,GO:0034451,GO:0034454,GO:0042802,GO:0045022,GO:0050768,GO:0051645,GO:0051959,GO:0070695,GO:0071539,GO:0097150 pericentriolar material|Golgi apparatus|cis-Golgi network|centrosome|cytosol|microtubule|endosome organization|lysosome organization|microtubule binding|endosome to lysosome transport|protein transport|interkinetic nuclear migration|cytoskeleton-dependent intracellular transport|cytoplasmic microtubule organization|centriolar satellite|microtubule anchoring at centrosome|identical protein binding|early endosome to late endosome transport|negative regulation of neurogenesis|Golgi localization|dynein light intermediate chain binding|FHF complex|protein localization to centrosome|neuronal stem cell population maintenance HOPX 10.3863947426572 7.68725495215503 13.0855345331594 1.70223761467558 0.767432436311154 0.413741782260405 1 0.0553182 0.0723471 0.0946342 0.0982119 GeneID:84525,Genbank:NM_139212.3,HGNC:HGNC:24961,MIM:607275 HOP homeobox GO:0001829,GO:0003677,GO:0005634,GO:0005737,GO:0006351,GO:0006357,GO:0045596,GO:0051131 trophectodermal cell differentiation|DNA binding|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|negative regulation of cell differentiation|chaperone-mediated protein complex assembly HORMAD2 3.48959649127677 4.55472144167109 2.42447154088245 0.532298532836936 -0.909692505087975 0.632595868944218 1 0.0228177 0.0432108 0.0327995 0 GeneID:150280,Genbank:XM_011529914.2,HGNC:HGNC:28383 HORMA domain containing 2 GO:0000795,GO:0005634,GO:0005694,GO:0051177,GO:0051321 synaptonemal complex|nucleus|chromosome|meiotic sister chromatid cohesion|meiotic cell cycle HOXA1 43.0361484112641 49.2462545683062 36.826042254222 0.747793767811177 -0.419287647207429 0.376059232757641 1 0.920106 0.602103 0.44088 0.627121 GeneID:3198,Genbank:NM_153620.2,HGNC:HGNC:5099,MIM:142955 homeobox A1 GO:0001228,GO:0005634,GO:0007275,GO:0007605,GO:0007634,GO:0009653,GO:0021599,GO:0042473,GO:0042802,GO:0043565,GO:0045944,GO:0048702,GO:0048839,GO:0048844,GO:0050795,GO:0050890,GO:0050905,GO:0060840,GO:0060876,GO:0090102,GO:0090103 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|multicellular organism development|sensory perception of sound|optokinetic behavior|anatomical structure morphogenesis|abducens nerve formation|outer ear morphogenesis|identical protein binding|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|embryonic neurocranium morphogenesis|inner ear development|artery morphogenesis|regulation of behavior|cognition|neuromuscular process|artery development|semicircular canal formation|cochlea development|cochlea morphogenesis HOXA10 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.0715903 0 0 GeneID:3206,Genbank:NM_018951.3,HGNC:HGNC:5100,MIM:142957 homeobox A10 GO:0000978,GO:0001077,GO:0001501,GO:0005634,GO:0005667,GO:0005737,GO:0007275,GO:0007283,GO:0007338,GO:0008584,GO:0009952,GO:0009954,GO:0030326,GO:0042826,GO:0045944,GO:0060065 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|skeletal system development|nucleus|transcription factor complex|cytoplasm|multicellular organism development|spermatogenesis|single fertilization|male gonad development|anterior/posterior pattern specification|proximal/distal pattern formation|embryonic limb morphogenesis|histone deacetylase binding|positive regulation of transcription from RNA polymerase II promoter|uterus development hsa05202 Transcriptional misregulation in cancer HOXA11 59.2988285525303 61.4117957229783 57.1858613820822 0.931186927671701 -0.102857289557388 0.77060812451675 1 0.807881 1.2099 0.97778 0.946441 GeneID:3207,Genbank:NM_005523.5,HGNC:HGNC:5101,MIM:142958 homeobox A11 hsa05202 Transcriptional misregulation in cancer HOXA13 16.0384835995239 13.1740929230559 18.9028742759919 1.43485205291896 0.520901988800793 0.500636421001029 1 0.205456 0.33689 0.451181 0.260148 GeneID:3209,Genbank:NM_000522.4,HGNC:HGNC:5102,MIM:142959 homeobox A13 GO:0001501,GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0043565 skeletal system development|DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|sequence-specific DNA binding HOXA2 6.67101334230424 6.07296192222811 7.26906476238037 1.19695543220423 0.259369435543763 0.900498147649683 1 0.0808145 0.196131 0.177275 0.14219 GeneID:3199,Genbank:NM_006735.3,HGNC:HGNC:5103,MIM:604685 homeobox A2 GO:0003700,GO:0005634,GO:0006351,GO:0007275,GO:0043231,GO:0043565 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|multicellular organism development|intracellular membrane-bounded organelle|sequence-specific DNA binding HOXA3 93.2646777885751 99.7804268988526 86.7489286782977 0.869398251485084 -0.201910900785437 0.527730391023864 1 0.607064 0.504634 0.492518 0.44889 GeneID:3200,Genbank:XM_011515343.3,HGNC:HGNC:5104,MIM:142954 homeobox A3 GO:0001525,GO:0001974,GO:0003700,GO:0005654,GO:0006351,GO:0008284,GO:0009952,GO:0010159,GO:0021615,GO:0030878,GO:0043565,GO:0048538,GO:0048645,GO:0048704,GO:0051216,GO:0060017,GO:0071837 angiogenesis|blood vessel remodeling|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|positive regulation of cell proliferation|anterior/posterior pattern specification|specification of animal organ position|glossopharyngeal nerve morphogenesis|thyroid gland development|sequence-specific DNA binding|thymus development|animal organ formation|embryonic skeletal system morphogenesis|cartilage development|parathyroid gland development|HMG box domain binding HOXA4 25.7967368865835 31.7291626125348 19.8643111606322 0.626058475075693 -0.675630680921446 0.228817534754135 1 0.730979 0.820027 0.33913 0.659552 GeneID:3201,Genbank:NM_002141.4,HGNC:HGNC:5105,MIM:142953 homeobox A4 GO:0003700,GO:0006351,GO:0007275,GO:0009653,GO:0016604,GO:0043565 DNA binding transcription factor activity|transcription, DNA-templated|multicellular organism development|anatomical structure morphogenesis|nuclear body|sequence-specific DNA binding HOXA5 67.8458637514649 66.8790163836633 68.8127111192666 1.02891332498837 0.0411214556272331 0.919528514552045 1 2.13657 1.88936 1.84777 2.31213 GeneID:3202,Genbank:NM_019102.3,HGNC:HGNC:5106,MIM:142952 homeobox A5 GO:0000978,GO:0001077,GO:0003016,GO:0005634,GO:0009952,GO:0010870,GO:0016477,GO:0016525,GO:0030878,GO:0033599,GO:0035264,GO:0043065,GO:0045639,GO:0045647,GO:0048286,GO:0048704,GO:0060435,GO:0060441,GO:0060480,GO:0060484,GO:0060535,GO:0060574,GO:0060638,GO:0060644,GO:0060749,GO:0060764 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|respiratory system process|nucleus|anterior/posterior pattern specification|positive regulation of receptor biosynthetic process|cell migration|negative regulation of angiogenesis|thyroid gland development|regulation of mammary gland epithelial cell proliferation|multicellular organism growth|positive regulation of apoptotic process|positive regulation of myeloid cell differentiation|negative regulation of erythrocyte differentiation|lung alveolus development|embryonic skeletal system morphogenesis|bronchiole development|epithelial tube branching involved in lung morphogenesis|lung goblet cell differentiation|lung-associated mesenchyme development|trachea cartilage morphogenesis|intestinal epithelial cell maturation|mesenchymal-epithelial cell signaling|mammary gland epithelial cell differentiation|mammary gland alveolus development|cell-cell signaling involved in mammary gland development HOXA6 30.0716158732252 28.1643926298864 31.9788391165639 1.13543506997662 0.183245207673089 0.850915760976436 1 0.499319 1.35293 1.1421 1.8536 GeneID:3203,Genbank:NM_024014.3,HGNC:HGNC:5107,MIM:142951 homeobox A6 GO:0003700,GO:0005634,GO:0006351,GO:0009952,GO:0043565,GO:0048704 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|anterior/posterior pattern specification|sequence-specific DNA binding|embryonic skeletal system morphogenesis HOXA7 369.471257638573 370.160485606096 368.78202967105 0.996276058659291 -0.00538254006845623 0.982306852266921 1 8.0836 8.04633 7.74726 8.44537 GeneID:3204,Genbank:NM_006896.3,HGNC:HGNC:5108,MIM:142950 homeobox A7 GO:0000122,GO:0000978,GO:0001077,GO:0001525,GO:0001953,GO:0002686,GO:0005634,GO:0005654,GO:0008134,GO:0009952,GO:0031965,GO:0043565,GO:0045617,GO:0045656,GO:0045892,GO:0045944,GO:0048704,GO:0048863 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|angiogenesis|negative regulation of cell-matrix adhesion|negative regulation of leukocyte migration|nucleus|nucleoplasm|transcription factor binding|anterior/posterior pattern specification|nuclear membrane|sequence-specific DNA binding|negative regulation of keratinocyte differentiation|negative regulation of monocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|embryonic skeletal system morphogenesis|stem cell differentiation HOXB13 157.658695246852 139.888829619348 175.428560874357 1.25405696331663 0.32660288149556 0.192427973697845 1 1.99871 2.0183 2.50791 2.57391 GeneID:10481,Genbank:NM_006361.5,HGNC:HGNC:5112,MIM:604607 homeobox B13 GO:0000122,GO:0001227,GO:0001525,GO:0005654,GO:0005667,GO:0006351,GO:0008544,GO:0009611,GO:0033574,GO:0040008,GO:0043565,GO:0060527,GO:0060743 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|angiogenesis|nucleoplasm|transcription factor complex|transcription, DNA-templated|epidermis development|response to wounding|response to testosterone|regulation of growth|sequence-specific DNA binding|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|epithelial cell maturation involved in prostate gland development HOXB2 9.99892470145022 12.2419763938261 7.75587300907434 0.633547456682386 -0.65847540455676 0.490074837458401 1 0.397603 0.418205 0.292823 0.206332 GeneID:3212,Genbank:NM_002145.3,HGNC:HGNC:5113,MIM:142967 homeobox B2 GO:0001228,GO:0002011,GO:0005634,GO:0005654,GO:0005829,GO:0007275,GO:0008015,GO:0009952,GO:0009953,GO:0016607,GO:0021569,GO:0021570,GO:0021612,GO:0043565,GO:0045944,GO:0048704,GO:0048857 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|morphogenesis of an epithelial sheet|nucleus|nucleoplasm|cytosol|multicellular organism development|blood circulation|anterior/posterior pattern specification|dorsal/ventral pattern formation|nuclear speck|rhombomere 3 development|rhombomere 4 development|facial nerve structural organization|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|embryonic skeletal system morphogenesis|neural nucleus development HOXB3 3949.60653375379 4434.58558189975 3464.62748560782 0.781274241216379 -0.356099045885964 0.00772530637070083 0.342738246075193 8.94904 9.48277 7.54391 7.16394 GeneID:3213,Genbank:XM_005257277.3,HGNC:HGNC:5114,MIM:142966 homeobox B3 GO:0000122,GO:0000978,GO:0001077,GO:0001525,GO:0002244,GO:0005634,GO:0009952,GO:0021546,GO:0021615,GO:0030878,GO:0045944,GO:0048704,GO:0050767,GO:0051216,GO:0060216,GO:0060324 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|angiogenesis|hematopoietic progenitor cell differentiation|nucleus|anterior/posterior pattern specification|rhombomere development|glossopharyngeal nerve morphogenesis|thyroid gland development|positive regulation of transcription from RNA polymerase II promoter|embryonic skeletal system morphogenesis|regulation of neurogenesis|cartilage development|definitive hemopoiesis|face development HOXB4 19.2207704226048 14.6923334036129 23.7492074415966 1.61643537409494 0.692815828938466 0.307841220867312 1 0.167906 0.340348 0.44613 0.293248 GeneID:3214,Genbank:NM_024015.4,HGNC:HGNC:5115,MIM:142965 homeobox B4 GO:0000122,GO:0002011,GO:0003700,GO:0005634,GO:0005813,GO:0006351,GO:0008283,GO:0009952,GO:0043565,GO:0045944,GO:0048103,GO:0048536,GO:0048539,GO:0048704,GO:0060216,GO:0060218,GO:2000738 negative regulation of transcription from RNA polymerase II promoter|morphogenesis of an epithelial sheet|DNA binding transcription factor activity|nucleus|centrosome|transcription, DNA-templated|cell proliferation|anterior/posterior pattern specification|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|somatic stem cell division|spleen development|bone marrow development|embryonic skeletal system morphogenesis|definitive hemopoiesis|hematopoietic stem cell differentiation|positive regulation of stem cell differentiation HOXB5 8.49319196931868 11.6558524424989 5.33053149613849 0.457326611025258 -1.12870322543157 0.265437160947268 1 0.135188 0.445795 0.156847 0.117181 GeneID:3215,Genbank:NM_002147.3,HGNC:HGNC:5116,MIM:142960 homeobox B5 GO:0000980,GO:0001205,GO:0001650,GO:0005634,GO:0005829,GO:0009653,GO:0009952,GO:0045446,GO:0048704 RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|fibrillar center|nucleus|cytosol|anatomical structure morphogenesis|anterior/posterior pattern specification|endothelial cell differentiation|embryonic skeletal system morphogenesis HOXB6 196.985038388535 212.7163464114 181.25373036567 0.85209121641794 -0.230920215574982 0.299112303954315 1 3.29866 4.02446 3.177 3.05334 GeneID:3216,Genbank:XM_005257284.3,HGNC:HGNC:5117,MIM:142961 homeobox B6 GO:0003700,GO:0003723,GO:0005634,GO:0006351,GO:0009952,GO:0034101,GO:0043565,GO:0048704 DNA binding transcription factor activity|RNA binding|nucleus|transcription, DNA-templated|anterior/posterior pattern specification|erythrocyte homeostasis|sequence-specific DNA binding|embryonic skeletal system morphogenesis HOXB7 734.945548166121 719.729180675729 750.161915656513 1.04228359193692 0.0597478697618784 0.727579492569438 1 21.6257 24.0342 23.038 24.5727 GeneID:3217,Genbank:NM_004502.3,HGNC:HGNC:5118,MIM:142962 homeobox B7 GO:0000978,GO:0001077,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0007275,GO:0009952,GO:0016604,GO:0030099,GO:0045944,GO:0048704,GO:0090190 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|multicellular organism development|anterior/posterior pattern specification|nuclear body|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|embryonic skeletal system morphogenesis|positive regulation of branching involved in ureteric bud morphogenesis HOXB8 40.2051694586864 43.0870487518161 37.3232901655568 0.866229905430309 -0.207178114503074 0.663416828129641 1 0.463233 0.455543 0.572457 0.352429 GeneID:3218,Genbank:XM_017024564.2,HGNC:HGNC:5119,MIM:142963 homeobox B8 GO:0000122,GO:0001227,GO:0005654,GO:0006351,GO:0007625,GO:0008344,GO:0009952,GO:0019233,GO:0021516,GO:0043565,GO:0045638,GO:0048704,GO:0048705 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleoplasm|transcription, DNA-templated|grooming behavior|adult locomotory behavior|anterior/posterior pattern specification|sensory perception of pain|dorsal spinal cord development|sequence-specific DNA binding|negative regulation of myeloid cell differentiation|embryonic skeletal system morphogenesis|skeletal system morphogenesis HOXB9 432.959846775737 459.371064070842 406.548629480631 0.885011402063268 -0.176232052579674 0.421709161860003 1 7.17843 7.03766 5.63331 7.30936 GeneID:3219,Genbank:NM_024017.4,HGNC:HGNC:5120,MIM:142964 homeobox B9 GO:0000977,GO:0005654,GO:0005739,GO:0006351,GO:0009952,GO:0030879,GO:0045944,GO:0048706,GO:0060070,GO:0060326,GO:0090575 RNA polymerase II regulatory region sequence-specific DNA binding|nucleoplasm|mitochondrion|transcription, DNA-templated|anterior/posterior pattern specification|mammary gland development|positive regulation of transcription from RNA polymerase II promoter|embryonic skeletal system development|canonical Wnt signaling pathway|cell chemotaxis|RNA polymerase II transcription factor complex HOXC10 711.865535148545 677.410552318872 746.320517978218 1.10172555686276 0.139764889005577 0.394579117081326 1 13.6436 13.7051 15.2891 14.8919 GeneID:3226,Genbank:NM_017409.3,HGNC:HGNC:5122,MIM:605560 homeobox C10 GO:0000977,GO:0001228,GO:0001501,GO:0005654,GO:0008284,GO:0009952,GO:0009954,GO:0016604,GO:0021520,GO:0030326,GO:0045944,GO:0050905 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|skeletal system development|nucleoplasm|positive regulation of cell proliferation|anterior/posterior pattern specification|proximal/distal pattern formation|nuclear body|spinal cord motor neuron cell fate specification|embryonic limb morphogenesis|positive regulation of transcription from RNA polymerase II promoter|neuromuscular process HOXC13 200.050759567587 204.317488993224 195.78403014195 0.95823432006079 -0.0615496090158812 0.801284588657231 1 4.58514 4.24773 4.2197 4.31645 GeneID:3229,Genbank:NM_017410.2,HGNC:HGNC:5125,MIM:142976 homeobox C13 HOXC4 233.651663824376 252.151364285451 215.151963363301 0.853265117057767 -0.22893402551508 0.2959681616747 1 4.64 4.07574 3.13484 4.16672 GeneID:3221,Genbank:NM_014620.5,HGNC:HGNC:5126,MIM:142974 homeobox C4 GO:0000980,GO:0001205,GO:0005634,GO:0009952,GO:0045944,GO:0048562,GO:0051216,GO:0071837 RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|nucleus|anterior/posterior pattern specification|positive regulation of transcription from RNA polymerase II promoter|embryonic organ morphogenesis|cartilage development|HMG box domain binding HOXC5 52.3061623892175 55.1849463215874 49.4273784568477 0.895667781731856 -0.158964383279995 0.69622163253013 1 1.70243 1.85876 1.42144 1.78938 GeneID:3222,Genbank:NM_018953.3,HGNC:HGNC:5127,MIM:142973 homeobox C5 GO:0003700,GO:0005654,GO:0006351,GO:0006357,GO:0007275,GO:0030054,GO:0043565 DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|multicellular organism development|cell junction|sequence-specific DNA binding HOXC6 148.902545763712 129.655165108036 168.149926419389 1.29690110131191 0.375068467186397 0.142050100405293 1 2.47164 2.45928 3.0308 3.51208 GeneID:3223,Genbank:NM_153693.4,HGNC:HGNC:5128,MIM:142972 homeobox C6 GO:0003700,GO:0005654,GO:0005829,GO:0006351,GO:0009952,GO:0043565,GO:0048706 DNA binding transcription factor activity|nucleoplasm|cytosol|transcription, DNA-templated|anterior/posterior pattern specification|sequence-specific DNA binding|embryonic skeletal system development HOXC8 24.7120345247352 23.2538699552048 26.1701990942655 1.12541263646346 0.170454067602487 0.781876130502123 1 0.310312 0.22872 0.340333 0.332769 GeneID:3224,Genbank:NM_022658.3,HGNC:HGNC:5129,MIM:142970 homeobox C8 GO:0000122,GO:0003700,GO:0005654,GO:0006351,GO:0009952,GO:0015630,GO:0030182,GO:0043565,GO:0048705 negative regulation of transcription from RNA polymerase II promoter|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|anterior/posterior pattern specification|microtubule cytoskeleton|neuron differentiation|sequence-specific DNA binding|skeletal system morphogenesis HOXC9 69.8543794607347 65.0726182549966 74.6361406664728 1.1469669220009 0.197823785291493 0.585440233493558 1 1.34257 1.56127 1.8572 1.6524 GeneID:3225,Genbank:NM_006897.2,HGNC:HGNC:5130,MIM:142971 homeobox C9 GO:0005654,GO:0006351,GO:0006355,GO:0009952,GO:0016235,GO:0043565,GO:0048704 nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|anterior/posterior pattern specification|aggresome|sequence-specific DNA binding|embryonic skeletal system morphogenesis HOXD1 3.56283249490918 5.18887166768327 1.93679332213509 0.373259052482951 -1.42175084507305 0.438118023363978 1 0.196891 0.11543 0 0.0854016 GeneID:3231,Genbank:NM_024501.2,HGNC:HGNC:5132,MIM:142987 homeobox D1 GO:0005654,GO:0006351,GO:0006355,GO:0019233,GO:0030182,GO:0043565,GO:0048706 nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|sensory perception of pain|neuron differentiation|sequence-specific DNA binding|embryonic skeletal system development HOXD10 396.66112176049 401.706334774144 391.615908746837 0.974881088113832 -0.0367018391540823 0.873886787413339 1 8.69824 7.00632 8.5662 7.0851 GeneID:3236,Genbank:NM_002148.3,HGNC:HGNC:5133,MIM:142984 homeobox D10 GO:0000977,GO:0001228,GO:0003682,GO:0005654,GO:0005829,GO:0007338,GO:0007519,GO:0008344,GO:0009952,GO:0009954,GO:0021520,GO:0030326,GO:0035136,GO:0035137,GO:0036464,GO:0048704,GO:0048935,GO:0050905 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|nucleoplasm|cytosol|single fertilization|skeletal muscle tissue development|adult locomotory behavior|anterior/posterior pattern specification|proximal/distal pattern formation|spinal cord motor neuron cell fate specification|embryonic limb morphogenesis|forelimb morphogenesis|hindlimb morphogenesis|cytoplasmic ribonucleoprotein granule|embryonic skeletal system morphogenesis|peripheral nervous system neuron development|neuromuscular process hsa05205,hsa05206 Proteoglycans in cancer|MicroRNAs in cancer HOXD11 639.240270114397 589.362413101672 689.118127127122 1.16926039361835 0.225596253007445 0.172784696970923 1 19.6595 17.932 22.2049 23.4854 GeneID:3237,Genbank:NM_021192.2,HGNC:HGNC:5134,MIM:142986 homeobox D11 GO:0001658,GO:0005654,GO:0006351,GO:0006355,GO:0009953,GO:0043565 branching involved in ureteric bud morphogenesis|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|dorsal/ventral pattern formation|sequence-specific DNA binding HOXD12 2.47913249256929 1.56626675524197 3.3919982298966 2.16565806465871 1.11480547408044 0.654265037277446 1 0 0.089156 0 0.0904854 GeneID:3238,Genbank:NM_021193.3,HGNC:HGNC:5135,MIM:142988 homeobox D12 GO:0001501,GO:0005634,GO:0005667,GO:0006351,GO:0006355,GO:0007389,GO:0042733,GO:0043565 skeletal system development|nucleus|transcription factor complex|transcription, DNA-templated|regulation of transcription, DNA-templated|pattern specification process|embryonic digit morphogenesis|sequence-specific DNA binding HOXD13 12.168051744042 14.644307128928 9.69179635915603 0.66181324072418 -0.595503939326329 0.472571309051854 1 0.0620516 0.121394 0.0661813 0.0617068 GeneID:3239,Genbank:XM_011511068.2,HGNC:HGNC:5136,MIM:142989 homeobox D13 GO:0000978,GO:0001077,GO:0001158,GO:0001228,GO:0001501,GO:0003677,GO:0003682,GO:0003700,GO:0005634,GO:0006355,GO:0006366,GO:0007275,GO:0009952,GO:0030539,GO:0033574,GO:0042127,GO:0042733,GO:0045944,GO:0048619,GO:0060527,GO:0060571,GO:0060602,GO:0060687 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|skeletal system development|DNA binding|chromatin binding|DNA binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|multicellular organism development|anterior/posterior pattern specification|male genitalia development|response to testosterone|regulation of cell proliferation|embryonic digit morphogenesis|positive regulation of transcription from RNA polymerase II promoter|embryonic hindgut morphogenesis|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|morphogenesis of an epithelial fold|branch elongation of an epithelium|regulation of branching involved in prostate gland morphogenesis HOXD3 27.6590606863064 20.4193027479385 34.8988186246743 1.709109221577 0.773244596190462 0.159228250320314 1 0.147691 0.17142 0.309573 0.225174 GeneID:3232,Genbank:XM_005246513.5,HGNC:HGNC:5137,MIM:142980 homeobox D3 GO:0000977,GO:0001228,GO:0005634,GO:0005654,GO:0006351,GO:0007160,GO:0007219,GO:0009952,GO:0010628,GO:0016235,GO:0016604,GO:0021615,GO:0030878,GO:0045666,GO:0045944,GO:0048704,GO:0051216 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|cell-matrix adhesion|Notch signaling pathway|anterior/posterior pattern specification|positive regulation of gene expression|aggresome|nuclear body|glossopharyngeal nerve morphogenesis|thyroid gland development|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|embryonic skeletal system morphogenesis|cartilage development HOXD4 260.577470481325 260.886405626421 260.268535336228 0.997631650109518 -0.00342085913865701 0.981185962191561 1 1.93829 2.25322 2.33008 1.86908 GeneID:3233,Genbank:XM_005246514.4,HGNC:HGNC:5138,MIM:142981 homeobox D4 GO:0000977,GO:0001228,GO:0005634,GO:0005654,GO:0007275,GO:0009952,GO:0030054,GO:0045944,GO:0048704,GO:0048863 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|nucleoplasm|multicellular organism development|anterior/posterior pattern specification|cell junction|positive regulation of transcription from RNA polymerase II promoter|embryonic skeletal system morphogenesis|stem cell differentiation HOXD8 337.606756161228 322.902925610088 352.310586712368 1.09107276140877 0.125747315248427 0.515141802248396 1 6.39791 5.78104 7.14071 7.33184 GeneID:3234,Genbank:NM_001199747.1,HGNC:HGNC:5139,MIM:142985 homeobox D8 GO:0000122,GO:0000977,GO:0001228,GO:0005634,GO:0008595,GO:0045944,GO:0048705 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|anterior/posterior axis specification, embryo|positive regulation of transcription from RNA polymerase II promoter|skeletal system morphogenesis HOXD9 189.298912796707 190.067200716883 188.530624876531 0.991915618083724 -0.0117106986200538 0.979580574874203 1 6.06388 5.53548 6.14977 5.27118 GeneID:3235,Genbank:NM_014213.3,HGNC:HGNC:5140,MIM:142982 homeobox D9 GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0005730,GO:0006351,GO:0007338,GO:0007519,GO:0008344,GO:0009952,GO:0009954,GO:0030879,GO:0035115,GO:0035137,GO:0045944,GO:0048704,GO:0048935 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|nucleolus|transcription, DNA-templated|single fertilization|skeletal muscle tissue development|adult locomotory behavior|anterior/posterior pattern specification|proximal/distal pattern formation|mammary gland development|embryonic forelimb morphogenesis|hindlimb morphogenesis|positive regulation of transcription from RNA polymerase II promoter|embryonic skeletal system morphogenesis|peripheral nervous system neuron development HP 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0284379 0 0 0 GeneID:3240,Genbank:NM_005143.4,HGNC:HGNC:5141,MIM:140100 haptoglobin GO:0002376,GO:0005576,GO:0006953,GO:0016209,GO:0030492,GO:0042742 immune system process|extracellular region|acute-phase response|antioxidant activity|hemoglobin binding|defense response to bacterium HP1BP3 5438.59185206356 5598.13170994751 5279.05199417961 0.943002463625336 -0.0846665548932348 0.535858483927821 1 28.7983 27.653 27.4142 26.1935 GeneID:50809,Genbank:XM_005245875.5,HGNC:HGNC:24973,MIM:616072 heterochromatin protein 1 binding protein 3 GO:0000786,GO:0003677,GO:0005634,GO:0005694,GO:0006334,GO:0006355,GO:0016607,GO:0031491,GO:0042127,GO:0070828,GO:0071456,GO:0097298 nucleosome|DNA binding|nucleus|chromosome|nucleosome assembly|regulation of transcription, DNA-templated|nuclear speck|nucleosome binding|regulation of cell proliferation|heterochromatin organization|cellular response to hypoxia|regulation of nucleus size HPCA 26.1464894504176 24.1859864844346 28.1069924164005 1.16211891685664 0.216757703838271 0.716682694776404 1 0.387022 0.373668 0.432712 0.439493 GeneID:3208,Genbank:XM_005270792.3,HGNC:HGNC:5144,MIM:142622 hippocalcin GO:0003779,GO:0005509,GO:0005737,GO:0005829,GO:0007420,GO:0010518,GO:0014070,GO:0019722,GO:0019898,GO:0019900,GO:0030424,GO:0031283,GO:0031584,GO:0032590,GO:0032809,GO:0032839,GO:0042802,GO:0043204,GO:0044327,GO:0045762,GO:0048839,GO:0060041,GO:0071257,GO:0071277,GO:0090314,GO:1901385,GO:1901986,GO:1902065,GO:1904009,GO:1904010 actin binding|calcium ion binding|cytoplasm|cytosol|brain development|positive regulation of phospholipase activity|response to organic cyclic compound|calcium-mediated signaling|extrinsic component of membrane|kinase binding|axon|negative regulation of guanylate cyclase activity|activation of phospholipase D activity|dendrite membrane|neuronal cell body membrane|dendrite cytoplasm|identical protein binding|perikaryon|dendritic spine head|positive regulation of adenylate cyclase activity|inner ear development|retina development in camera-type eye|cellular response to electrical stimulus|cellular response to calcium ion|positive regulation of protein targeting to membrane|regulation of voltage-gated calcium channel activity|response to ketamine|response to L-glutamate|cellular response to monosodium glutamate|response to Aroclor 1254 HPCAL1 1539.55250326962 1555.43177882597 1523.67322771327 0.979582163907775 -0.0297615891317178 0.802586066739161 1 9.76597 11.6692 11.1637 10.5134 GeneID:3241,Genbank:XM_017003952.1,HGNC:HGNC:5145,MIM:600207 hippocalcin like 1 GO:0005509,GO:0016020,GO:0070062 calcium ion binding|membrane|extracellular exosome HPCAL4 1.29721791692082 2.59443583384164 0 0 -Inf 0.298334034769393 1 0.0275273 0.0168514 0 0 GeneID:51440,Genbank:NM_016257.3,HGNC:HGNC:18212 hippocalcin like 4 GO:0005246,GO:0005509,GO:0005622,GO:0007165,GO:0007417,GO:0008022,GO:0019904 calcium channel regulator activity|calcium ion binding|intracellular|signal transduction|central nervous system development|protein C-terminus binding|protein domain specific binding HPD 63.4730469776967 60.5561144329025 66.3899795224909 1.09633816740426 0.132692868724378 0.704874141603833 1 0.991402 0.665206 0.875296 0.942381 GeneID:3242,Genbank:NM_001171993.1,HGNC:HGNC:5147,MIM:609695 4-hydroxyphenylpyruvate dioxygenase GO:0000139,GO:0003868,GO:0005789,GO:0005829,GO:0006559,GO:0006572,GO:0046872,GO:0070062 Golgi membrane|4-hydroxyphenylpyruvate dioxygenase activity|endoplasmic reticulum membrane|cytosol|L-phenylalanine catabolic process|tyrosine catabolic process|metal ion binding|extracellular exosome hsa00130,hsa00350,hsa00360 Ubiquinone and other terpenoid-quinone biosynthesis|Tyrosine metabolism|Phenylalanine metabolism HPDL 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0302506 0 0 GeneID:84842,Genbank:NM_032756.2,HGNC:HGNC:28242 4-hydroxyphenylpyruvate dioxygenase like GO:0009072,GO:0016701,GO:0046872,GO:0051213 aromatic amino acid family metabolic process|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen|metal ion binding|dioxygenase activity HPF1 321.192923596139 329.802142857068 312.58370433521 0.947791611137833 -0.0773582030911541 0.707471518609079 1 10.7544 10.7256 10.0514 9.60742 GeneID:54969,Genbank:NM_017867.2,HGNC:HGNC:26051,MIM:616614 histone PARylation factor 1 GO:0005634,GO:0006974,GO:0010835,GO:0018312,GO:0042393 nucleus|cellular response to DNA damage stimulus|regulation of protein ADP-ribosylation|peptidyl-serine ADP-ribosylation|histone binding HPGD 4.66520300947495 2.54640955915669 6.7839964597932 2.66414192304552 1.41367093909842 0.350959078344633 1 0.0110366 0.0215666 0.0533757 0.0795307 GeneID:3248,Genbank:NM_001256306.1,HGNC:HGNC:5154,MIM:601688 15-hydroxyprostaglandin dehydrogenase hsa05202 Transcriptional misregulation in cancer HPGDS 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:27306,Genbank:NM_014485.2,HGNC:HGNC:17890,MIM:602598 hematopoietic prostaglandin D synthase GO:0000287,GO:0004364,GO:0004667,GO:0005509,GO:0005737,GO:0005829,GO:0006693,GO:0007165,GO:0007626,GO:0019371,GO:0042803,GO:1901687,GO:2000255 magnesium ion binding|glutathione transferase activity|prostaglandin-D synthase activity|calcium ion binding|cytoplasm|cytosol|prostaglandin metabolic process|signal transduction|locomotory behavior|cyclooxygenase pathway|protein homodimerization activity|glutathione derivative biosynthetic process|negative regulation of male germ cell proliferation hsa00480,hsa00590,hsa00980,hsa00982,hsa05204 Glutathione metabolism|Arachidonic acid metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Chemical carcinogenesis HPRT1 1779.0065321071 1797.81789869015 1760.19516552406 0.979073112358322 -0.0305114976749795 0.828975338623473 1 55.0464 59.3206 58.5972 54.0673 GeneID:3251,Genbank:NM_000194.2,HGNC:HGNC:5157,MIM:308000 hypoxanthine phosphoribosyltransferase 1 hsa00230,hsa00983 Purine metabolism|Drug metabolism - other enzymes HPS1 1294.50067152116 1181.70448923552 1407.2968538068 1.19090421220048 0.252057377819323 0.0905371657003733 0.979717040875575 7.7244 8.01161 9.91456 9.887 GeneID:3257,Genbank:NM_001322483.1,HGNC:HGNC:5163,MIM:604982 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 HPS3 587.315634693152 573.170439526864 601.460829859441 1.04935772744304 0.0695065784203427 0.664287446761797 1 4.58208 4.23016 5.14563 4.28939 GeneID:84343,Genbank:NM_032383.4,HGNC:HGNC:15597,MIM:606118 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 HPS4 595.943569653513 574.487783254428 617.399356052599 1.07469536176223 0.103927764595762 0.54361138725898 1 1.79615 1.97623 2.08813 2.19387 GeneID:89781,Genbank:NM_001349905.1,HGNC:HGNC:15844,MIM:606682 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 HPS5 713.516762090416 738.350876949254 688.682647231578 0.932730858365203 -0.100467246733498 0.538261073935852 1 4.63663 4.6989 4.74121 4.0987 GeneID:11234,Genbank:NM_181508.1,HGNC:HGNC:17022,MIM:607521 HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 GO:0006996,GO:0007596,GO:0031084,GO:0043473 organelle organization|blood coagulation|BLOC-2 complex|pigmentation HPS6 868.741270197353 899.621568811949 837.860971582757 0.931348247562857 -0.102607377061083 0.582955543176892 1 16.1835 18.771 15.6096 17.6347 GeneID:79803,Genbank:NM_024747.5,HGNC:HGNC:18817,MIM:607522 HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 GO:0005765,GO:0005783,GO:0006996,GO:0007596,GO:0016020,GO:0017137,GO:0030318,GO:0030742,GO:0031084,GO:0031901,GO:0032418,GO:0072657 lysosomal membrane|endoplasmic reticulum|organelle organization|blood coagulation|membrane|Rab GTPase binding|melanocyte differentiation|GTP-dependent protein binding|BLOC-2 complex|early endosome membrane|lysosome localization|protein localization to membrane HPSE 721.887031419809 753.167671866706 690.606390972912 0.916935785707932 -0.125107391475491 0.448356141524676 1 7.08174 6.99376 6.7303 6.13745 GeneID:10855,Genbank:NM_001166498.2,HGNC:HGNC:5164,MIM:604724 heparanase GO:0004566,GO:0005576,GO:0005578,GO:0005634,GO:0005654,GO:0005764,GO:0005765,GO:0006027,GO:0006029,GO:0007160,GO:0010575,GO:0030194,GO:0030200,GO:0030305,GO:0033690,GO:0035580,GO:0043202,GO:0043231,GO:0043312,GO:0045121,GO:0045545,GO:0046983,GO:0051797,GO:0051798,GO:0051897,GO:0060055,GO:0061042 beta-glucuronidase activity|extracellular region|proteinaceous extracellular matrix|nucleus|nucleoplasm|lysosome|lysosomal membrane|glycosaminoglycan catabolic process|proteoglycan metabolic process|cell-matrix adhesion|positive regulation of vascular endothelial growth factor production|positive regulation of blood coagulation|heparan sulfate proteoglycan catabolic process|heparanase activity|positive regulation of osteoblast proliferation|specific granule lumen|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation|membrane raft|syndecan binding|protein dimerization activity|regulation of hair follicle development|positive regulation of hair follicle development|positive regulation of protein kinase B signaling|angiogenesis involved in wound healing|vascular wound healing hsa00531,hsa05205 Glycosaminoglycan degradation|Proteoglycans in cancer HPSE2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00662865 0 GeneID:60495,Genbank:NM_001166245.1,HGNC:HGNC:18374,MIM:613469 heparanase 2 (inactive) GO:0005578,GO:0005622,GO:0005886,GO:0006027,GO:0008284,GO:0030198,GO:0030305,GO:0043395 proteinaceous extracellular matrix|intracellular|plasma membrane|glycosaminoglycan catabolic process|positive regulation of cell proliferation|extracellular matrix organization|heparanase activity|heparan sulfate proteoglycan binding hsa00531,hsa05205 Glycosaminoglycan degradation|Proteoglycans in cancer HPX 0.996216306175209 0.538097676642304 1.45433493570811 2.70273409241064 1.43441957978558 0.835201184388344 1 0 0 0.0504909 0.0235052 GeneID:3263,Genbank:NM_000613.2,HGNC:HGNC:5171,MIM:142290 hemopexin GO:0002639,GO:0002925,GO:0005576,GO:0005615,GO:0006879,GO:0006898,GO:0015232,GO:0015886,GO:0016032,GO:0020027,GO:0042168,GO:0042531,GO:0046872,GO:0060335,GO:0070062,GO:0071682,GO:0072562 positive regulation of immunoglobulin production|positive regulation of humoral immune response mediated by circulating immunoglobulin|extracellular region|extracellular space|cellular iron ion homeostasis|receptor-mediated endocytosis|heme transporter activity|heme transport|viral process|hemoglobin metabolic process|heme metabolic process|positive regulation of tyrosine phosphorylation of STAT protein|metal ion binding|positive regulation of interferon-gamma-mediated signaling pathway|extracellular exosome|endocytic vesicle lumen|blood microparticle HR 553.476754546442 475.515011370966 631.438497721918 1.32790444596356 0.409151336222245 0.0181165963782559 0.548508468518913 3.14655 3.55923 4.31062 4.61658 GeneID:55806,Genbank:XM_005273569.2,HGNC:HGNC:5172,MIM:602302 HR, lysine demethylase and nuclear receptor corepressor GO:0000785,GO:0000976,GO:0003677,GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0016491,GO:0016604,GO:0031490,GO:0032454,GO:0033169,GO:0045892,GO:0046872 chromatin|transcription regulatory region sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|oxidoreductase activity|nuclear body|chromatin DNA binding|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|negative regulation of transcription, DNA-templated|metal ion binding HRAS 782.90667622822 756.560971061685 809.252381394754 1.06964595366204 0.0971333523092357 0.632768414658871 1 17.2704 19.2706 18.3753 21.8205 GeneID:3265,Genbank:NM_005343.3,HGNC:HGNC:5173,MIM:190020 HRas proto-oncogene, GTPase GO:0003924,GO:0005198,GO:0005525,GO:0007165,GO:0016020,GO:0019028,GO:0020002 GTPase activity|structural molecule activity|GTP binding|signal transduction|membrane|viral capsid|host cell plasma membrane hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04062,hsa04068,hsa04071,hsa04072,hsa04137,hsa04140,hsa04144,hsa04150,hsa04151,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04371,hsa04510,hsa04540,hsa04550,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04933,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Endocytosis|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer HRASLS 157.881643286956 166.515364458461 149.24792211545 0.896301206803543 -0.157944455754903 0.539778565346161 1 2.71455 2.54115 2.14551 2.62607 GeneID:57110,Genbank:XM_011513035.2,HGNC:HGNC:14922,MIM:606487 HRAS like suppressor GO:0016021,GO:0016042,GO:0016740,GO:0016787 integral component of membrane|lipid catabolic process|transferase activity|hydrolase activity HRASLS2 2.02438538477488 2.59443583384164 1.45433493570811 0.560559223218347 -0.835061292722276 0.824506951681651 1 0.0352323 0.0635227 0.0659299 0.0305421 GeneID:54979,Genbank:XM_011545120.2,HGNC:HGNC:17824,MIM:613866 HRAS like suppressor 2 GO:0005829,GO:0016021,GO:0016042,GO:0016746,GO:0016787,GO:0036152 cytosol|integral component of membrane|lipid catabolic process|transferase activity, transferring acyl groups|hydrolase activity|phosphatidylethanolamine acyl-chain remodeling HRC 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00770017 0 0 GeneID:3270,Genbank:NM_002152.2,HGNC:HGNC:5178,MIM:142705 histidine rich calcium binding protein GO:0002027,GO:0005509,GO:0005788,GO:0006936,GO:0010460,GO:0010880,GO:0010881,GO:0030018,GO:0033017,GO:0033018,GO:0033135,GO:0043687,GO:0044267,GO:0044325,GO:0045823,GO:0051117,GO:0051480,GO:0051481,GO:0060314,GO:1901844,GO:1901899,GO:1903169 regulation of heart rate|calcium ion binding|endoplasmic reticulum lumen|muscle contraction|positive regulation of heart rate|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|Z disc|sarcoplasmic reticulum membrane|sarcoplasmic reticulum lumen|regulation of peptidyl-serine phosphorylation|post-translational protein modification|cellular protein metabolic process|ion channel binding|positive regulation of heart contraction|ATPase binding|regulation of cytosolic calcium ion concentration|negative regulation of cytosolic calcium ion concentration|regulation of ryanodine-sensitive calcium-release channel activity|regulation of cell communication by electrical coupling involved in cardiac conduction|positive regulation of relaxation of cardiac muscle|regulation of calcium ion transmembrane transport HRCT1 903.157210303171 733.411945310104 1072.90247529624 1.46289201063202 0.548823274961114 0.000415885109979654 0.0564475925545266 30.5584 28.6773 42.8827 45.9727 GeneID:646962,Genbank:NM_001039792.1,HGNC:HGNC:33872 histidine rich carboxyl terminus 1 GO:0016021 integral component of membrane HRH1 553.553851909954 588.036277719855 519.071426100054 0.882720073177769 -0.179972089703844 0.293025289738383 1 3.53061 3.63026 3.57456 2.89837 GeneID:3269,Genbank:NM_001098213.1,HGNC:HGNC:5182,MIM:600167 histamine receptor H1 GO:0004930,GO:0004969,GO:0005829,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007200,GO:0007613,GO:0008542,GO:0019229,GO:0032962,GO:0043114,GO:0045907,GO:0048016,GO:0048167,GO:0048245,GO:0050804,GO:0071420 G-protein coupled receptor activity|histamine receptor activity|cytosol|plasma membrane|integral component of plasma membrane|inflammatory response|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|memory|visual learning|regulation of vasoconstriction|positive regulation of inositol trisphosphate biosynthetic process|regulation of vascular permeability|positive regulation of vasoconstriction|inositol phosphate-mediated signaling|regulation of synaptic plasticity|eosinophil chemotaxis|modulation of chemical synaptic transmission|cellular response to histamine hsa04020,hsa04080,hsa04750 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels HRH2 29.186764013102 25.9061407188394 32.4673873073647 1.25326993548498 0.32569718293061 0.571620100849212 1 0.10266 0.146652 0.1423 0.175452 GeneID:3274,Genbank:XM_006714865.3,HGNC:HGNC:5183,MIM:142703 histamine receptor H2 hsa04020,hsa04080,hsa04971 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Gastric acid secretion HRK 4.50308289131746 4.16070258908361 4.84546319355132 1.16457811867263 0.219807417257297 0.951858217831861 1 0.0420278 0.023224 0.023956 0.0447009 GeneID:8739,Genbank:NM_003806.3,HGNC:HGNC:5185,MIM:603447 harakiri, BCL2 interacting protein hsa04210 Apoptosis HRNR 2.7785025256832 3.13253351048394 2.42447154088245 0.773965077394463 -0.369659623874888 0.960663839078737 1 0.020665 0.00914928 0.00969382 0.00454323 GeneID:388697,Genbank:NM_001009931.2,HGNC:HGNC:20846,MIM:616293 hornerin GO:0001533,GO:0005509,GO:0005576,GO:0005634,GO:0005737,GO:0031424,GO:0035578,GO:0036457,GO:0043163,GO:0043312,GO:0046914,GO:0048471,GO:0061436,GO:0070062 cornified envelope|calcium ion binding|extracellular region|nucleus|cytoplasm|keratinization|azurophil granule lumen|keratohyalin granule|cell envelope organization|neutrophil degranulation|transition metal ion binding|perinuclear region of cytoplasm|establishment of skin barrier|extracellular exosome HS1BP3 578.516068823043 478.560283986333 678.471853659752 1.41773539585898 0.503588295127626 0.00288521025051248 0.200041244035532 1.71512 1.74699 2.46558 2.41504 GeneID:64342,Genbank:XM_017004699.2,HGNC:HGNC:24979,MIM:609359 HCLS1 binding protein 3 GO:0005739,GO:0005783,GO:0035091,GO:0042981 mitochondrion|endoplasmic reticulum|phosphatidylinositol binding|regulation of apoptotic process HS2ST1 711.241889458097 720.72690678815 701.756872128043 0.973679302824082 -0.0384814195105738 0.841645126748793 1 5.02386 4.62673 4.84845 4.43613 GeneID:9653,Genbank:NM_012262.3,HGNC:HGNC:5193,MIM:604844 heparan sulfate 2-O-sulfotransferase 1 GO:0000139,GO:0004394,GO:0006024,GO:0016020,GO:0016021 Golgi membrane|heparan sulfate 2-O-sulfotransferase activity|glycosaminoglycan biosynthetic process|membrane|integral component of membrane hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS3ST1 61.299154278129 55.2329725962723 67.3653359599856 1.21965798314705 0.286476643530354 0.45387970676389 1 0.158583 0.194764 0.239899 0.214402 GeneID:9957,Genbank:XM_011513913.3,HGNC:HGNC:5194,MIM:603244 heparan sulfate-glucosamine 3-sulfotransferase 1 GO:0005796,GO:0006024,GO:0008146,GO:0008467,GO:0016021 Golgi lumen|glycosaminoglycan biosynthetic process|sulfotransferase activity|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|integral component of membrane hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS3ST3A1 4162.6429009798 4181.01101268226 4144.27478927735 0.991213554976661 -0.0127321782281637 0.919089995854981 1 11.8969 12.7015 13.3012 11.3504 GeneID:9955,Genbank:NM_006042.2,HGNC:HGNC:5196,MIM:604057 heparan sulfate-glucosamine 3-sulfotransferase 3A1 GO:0000139,GO:0006024,GO:0008146,GO:0008467,GO:0016021,GO:0033872 Golgi membrane|glycosaminoglycan biosynthetic process|sulfotransferase activity|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|integral component of membrane|[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS3ST3B1 1691.66693512009 1583.30394580433 1800.02992443584 1.13688210605792 0.185082655440238 0.19032113713008 1 10.6778 10.2642 12.9359 10.6146 GeneID:9953,Genbank:NM_006041.2,HGNC:HGNC:5198,MIM:604058 heparan sulfate-glucosamine 3-sulfotransferase 3B1 GO:0000139,GO:0005887,GO:0006024,GO:0008467,GO:0015012,GO:0015015,GO:0033872 Golgi membrane|integral component of plasma membrane|glycosaminoglycan biosynthetic process|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS3ST5 66.0677916932329 53.1286081643881 79.0069752220777 1.48708912113071 0.572491110578297 0.113420960794959 1 0.151033 0.177391 0.353894 0.266377 GeneID:222537,Genbank:XM_017010474.2,HGNC:HGNC:19419,MIM:609407 heparan sulfate-glucosamine 3-sulfotransferase 5 GO:0000139,GO:0006024,GO:0006477,GO:0008467,GO:0015015,GO:0016021,GO:0046596,GO:0050656,GO:0050819 Golgi membrane|glycosaminoglycan biosynthetic process|protein sulfation|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|integral component of membrane|regulation of viral entry into host cell|3'-phosphoadenosine 5'-phosphosulfate binding|negative regulation of coagulation hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS6ST1 1392.57643431325 1294.91977474192 1490.23309388457 1.15083043980973 0.20267528641034 0.178490552688638 1 13.7123 15.4846 17.5226 16.6806 GeneID:9394,Genbank:NM_004807.2,HGNC:HGNC:5201,MIM:604846 heparan sulfate 6-O-sulfotransferase 1 GO:0000139,GO:0001525,GO:0005887,GO:0006024,GO:0008146,GO:0015015,GO:0017095,GO:0048286,GO:0048666,GO:0060716 Golgi membrane|angiogenesis|integral component of plasma membrane|glycosaminoglycan biosynthetic process|sulfotransferase activity|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|heparan sulfate 6-O-sulfotransferase activity|lung alveolus development|neuron development|labyrinthine layer blood vessel development hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS6ST2 547.68959633473 585.969113906693 509.410078762767 0.869346296030003 -0.201997119175046 0.45262629256407 1 3.73891 3.09516 3.54086 2.52678 GeneID:90161,Genbank:NM_147175.3,HGNC:HGNC:19133,MIM:300545 heparan sulfate 6-O-sulfotransferase 2 GO:0000139,GO:0005654,GO:0006024,GO:0015015,GO:0016021,GO:0017095,GO:0070062 Golgi membrane|nucleoplasm|glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|integral component of membrane|heparan sulfate 6-O-sulfotransferase activity|extracellular exosome hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HS6ST3 193.958360695892 189.682990519404 198.233730872381 1.04507910977976 0.0636121547148778 0.796247684623855 1 0.330838 0.355433 0.414315 0.312598 GeneID:266722,Genbank:XM_017020543.2,HGNC:HGNC:19134,MIM:609401 heparan sulfate 6-O-sulfotransferase 3 GO:0015015,GO:0016021,GO:0017095 heparan sulfate proteoglycan biosynthetic process, enzymatic modification|integral component of membrane|heparan sulfate 6-O-sulfotransferase activity hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin HSBP1 4050.3921437198 4341.81902510661 3758.96526233299 0.865758162787702 -0.207964009972429 0.121275358517891 1 85.9803 92.9363 72.5045 82.1747 GeneID:3281,Genbank:NM_001537.3,HGNC:HGNC:5203,MIM:604553 heat shock factor binding protein 1 GO:0000122,GO:0003714,GO:0005634,GO:0005654,GO:0005856,GO:0006936,GO:0035987,GO:0042802,GO:1900034 negative regulation of transcription from RNA polymerase II promoter|transcription corepressor activity|nucleus|nucleoplasm|cytoskeleton|muscle contraction|endodermal cell differentiation|identical protein binding|regulation of cellular response to heat HSBP1L1 9.03509615372617 13.2221191977408 4.84807310971151 0.366663848450244 -1.44747006563254 0.141360114421467 1 0.693628 0.765423 0.356056 0.198021 GeneID:440498,Genbank:NM_001136180.1,HGNC:HGNC:37243 heat shock factor binding protein 1 like 1 GO:0003714 transcription corepressor activity HSCB 187.320750106459 192.441122487516 182.200377725402 0.946785049735 -0.0788911695958498 0.735038902998567 1 2.1326 2.51186 2.11429 2.24319 GeneID:150274,Genbank:XM_024452163.1,HGNC:HGNC:28913,MIM:608142 HscB mitochondrial iron-sulfur cluster cochaperone GO:0001671,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0016226,GO:0042802,GO:0046872,GO:0051087,GO:0051259,GO:0097428 ATPase activator activity|nucleus|cytoplasm|mitochondrion|cytosol|iron-sulfur cluster assembly|identical protein binding|metal ion binding|chaperone binding|protein oligomerization|protein maturation by iron-sulfur cluster transfer HSD11B1 1.02566752891457 1.56626675524197 0.48506830258717 0.309697119576692 -1.69107012999473 0.789536483244536 1 0 0.0263866 0 0 GeneID:3290,Genbank:NM_001206741.1,HGNC:HGNC:5208,MIM:600713 hydroxysteroid 11-beta dehydrogenase 1 GO:0003845,GO:0005789,GO:0006704,GO:0016020,GO:0016021,GO:0030324,GO:0070524 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity|endoplasmic reticulum membrane|glucocorticoid biosynthetic process|membrane|integral component of membrane|lung development|11-beta-hydroxysteroid dehydrogenase (NADP+) activity hsa00140,hsa00980,hsa05204 Steroid hormone biosynthesis|Metabolism of xenobiotics by cytochrome P450|Chemical carcinogenesis HSD11B1L 235.400744848616 197.975986733102 272.82550296413 1.37807371220195 0.462653058857893 0.0350899704930707 0.733682725087494 3.27074 3.79612 4.33017 5.43782 GeneID:374875,Genbank:NM_001267868.1,HGNC:HGNC:30419 hydroxysteroid 11-beta dehydrogenase 1 like GO:0005576,GO:0016491 extracellular region|oxidoreductase activity HSD11B2 2.94062264384068 1.51824048055703 4.36300480712434 2.87372446130773 1.5229217398183 0.472469947799888 1 0.0327792 0.0558864 0.151372 0.0845359 GeneID:3291,Genbank:NM_000196.3,HGNC:HGNC:5209,MIM:614232 hydroxysteroid 11-beta dehydrogenase 2 GO:0001666,GO:0002017,GO:0003845,GO:0005496,GO:0005789,GO:0006704,GO:0007565,GO:0032094,GO:0032868,GO:0042493,GO:0051287,GO:0051384 response to hypoxia|regulation of blood volume by renal aldosterone|11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity|steroid binding|endoplasmic reticulum membrane|glucocorticoid biosynthetic process|female pregnancy|response to food|response to insulin|response to drug|NAD binding|response to glucocorticoid hsa00140,hsa04960 Steroid hormone biosynthesis|Aldosterone-regulated sodium reabsorption HSD17B1 49.3641119945005 47.3536125453775 51.3746114436236 1.08491430077046 0.117581086230567 0.816593186935387 1 0.391482 0.588242 0.678191 0.745243 GeneID:3292,Genbank:NM_001330219.2,HGNC:HGNC:5210,MIM:109684 hydroxysteroid 17-beta dehydrogenase 1 hsa00140,hsa04913 Steroid hormone biosynthesis|Ovarian steroidogenesis HSD17B10 1465.45373967858 1473.69469890272 1457.21278045445 0.988815920651314 -0.016226123024736 0.90790839090163 1 58.1945 59.0933 57.7347 59.6669 GeneID:3028,Genbank:NM_001037811.2,HGNC:HGNC:4800,MIM:300256 hydroxysteroid 17-beta dehydrogenase 10 GO:0000049,GO:0003723,GO:0003857,GO:0005737,GO:0005739,GO:0005759,GO:0005886,GO:0006629,GO:0007005,GO:0008709,GO:0009083,GO:0030283,GO:0030678,GO:0047015,GO:0051289,GO:0070901,GO:0090646,GO:0097745,GO:1990180 tRNA binding|RNA binding|3-hydroxyacyl-CoA dehydrogenase activity|cytoplasm|mitochondrion|mitochondrial matrix|plasma membrane|lipid metabolic process|mitochondrion organization|cholate 7-alpha-dehydrogenase activity|branched-chain amino acid catabolic process|testosterone dehydrogenase [NAD(P)] activity|mitochondrial ribonuclease P complex|3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity|protein homotetramerization|mitochondrial tRNA methylation|mitochondrial tRNA processing|mitochondrial tRNA 5'-end processing|mitochondrial tRNA 3'-end processing hsa00280,hsa05010 Valine, leucine and isoleucine degradation|Alzheimer disease HSD17B11 303.488455271429 287.118921612948 319.857988929911 1.11402615729066 0.15578310749885 0.440002197204257 1 5.96212 6.65565 7.09828 6.63586 GeneID:51170,Genbank:NM_016245.4,HGNC:HGNC:22960,MIM:612831 hydroxysteroid 17-beta dehydrogenase 11 GO:0004303,GO:0005576,GO:0005737,GO:0005811,GO:0005829,GO:0006703,GO:0006710,GO:0016229 estradiol 17-beta-dehydrogenase activity|extracellular region|cytoplasm|lipid droplet|cytosol|estrogen biosynthetic process|androgen catabolic process|steroid dehydrogenase activity HSD17B12 1937.23611779695 2012.97174245366 1861.50049314024 0.924752421447909 -0.112860921861621 0.443240555955644 1 28.5707 25.3583 26.2562 23.9415 GeneID:51144,Genbank:XM_024448573.1,HGNC:HGNC:18646,MIM:609574 hydroxysteroid 17-beta dehydrogenase 12 GO:0001968,GO:0004303,GO:0005518,GO:0005578,GO:0005789,GO:0006633,GO:0006703,GO:0008201,GO:0010811,GO:0016021,GO:0016509,GO:0030198,GO:0035338,GO:0102339,GO:0102340,GO:0102341,GO:0102342 fibronectin binding|estradiol 17-beta-dehydrogenase activity|collagen binding|proteinaceous extracellular matrix|endoplasmic reticulum membrane|fatty acid biosynthetic process|estrogen biosynthetic process|heparin binding|positive regulation of cell-substrate adhesion|integral component of membrane|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|extracellular matrix organization|long-chain fatty-acyl-CoA biosynthetic process|3-oxo-arachidoyl-CoA reductase activity|3-oxo-behenoyl-CoA reductase activity|3-oxo-lignoceroyl-CoA reductase activity|3-oxo-cerotoyl-CoA reductase activity hsa00062,hsa00140,hsa01040 Fatty acid elongation|Steroid hormone biosynthesis|Biosynthesis of unsaturated fatty acids HSD17B13 1.24418854286568 1.51824048055703 0.97013660517434 0.638987444741564 -0.646140510486663 0.974454614671682 1 0.0186191 0.0355448 0.0358723 0 GeneID:345275,Genbank:NM_001136230.2,HGNC:HGNC:18685,MIM:612127 hydroxysteroid 17-beta dehydrogenase 13 GO:0005576,GO:0005811,GO:0005829,GO:0016491,GO:0034389,GO:0046889 extracellular region|lipid droplet|cytosol|oxidoreductase activity|lipid particle organization|positive regulation of lipid biosynthetic process HSD17B14 295.681595161259 224.976923114587 366.38626720793 1.6285504403548 0.703588404365556 0.000462432037855443 0.0595102925339596 6.1473 5.4052 10.2482 9.18231 GeneID:51171,Genbank:XM_005258969.4,HGNC:HGNC:23238,MIM:612832 hydroxysteroid 17-beta dehydrogenase 14 GO:0004303,GO:0005829,GO:0006703,GO:0006706,GO:0042802,GO:0047045 estradiol 17-beta-dehydrogenase activity|cytosol|estrogen biosynthetic process|steroid catabolic process|identical protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity HSD17B3 6.17180571365989 3.13253351048394 9.21107791683585 2.94045630669497 1.55604005313109 0.208949155512075 1 0.011164 0.0104927 0.0638878 0.0198686 GeneID:3293,Genbank:XM_011518618.2,HGNC:HGNC:5212,MIM:605573 hydroxysteroid 17-beta dehydrogenase 3 hsa00140 Steroid hormone biosynthesis HSD17B4 2142.66138125059 2199.92602697028 2085.39673553091 0.947939480675587 -0.0771331388400374 0.600105961651932 1 25.869 23.9261 25.3279 22.7763 GeneID:3295,Genbank:NM_001292027.1,HGNC:HGNC:5213,MIM:601860 hydroxysteroid 17-beta dehydrogenase 4 GO:0000038,GO:0001649,GO:0003857,GO:0005102,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0006635,GO:0006699,GO:0008209,GO:0008210,GO:0016020,GO:0016508,GO:0016853,GO:0033540,GO:0033989,GO:0036109,GO:0036111,GO:0036112,GO:0042803,GO:0044594,GO:0060009 very long-chain fatty acid metabolic process|osteoblast differentiation|3-hydroxyacyl-CoA dehydrogenase activity|receptor binding|mitochondrion|peroxisome|peroxisomal membrane|peroxisomal matrix|fatty acid beta-oxidation|bile acid biosynthetic process|androgen metabolic process|estrogen metabolic process|membrane|long-chain-enoyl-CoA hydratase activity|isomerase activity|fatty acid beta-oxidation using acyl-CoA oxidase|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|alpha-linolenic acid metabolic process|very long-chain fatty-acyl-CoA metabolic process|medium-chain fatty-acyl-CoA metabolic process|protein homodimerization activity|17-beta-hydroxysteroid dehydrogenase (NAD+) activity|Sertoli cell development hsa00120,hsa01040,hsa04146 Primary bile acid biosynthesis|Biosynthesis of unsaturated fatty acids|Peroxisome HSD17B6 26.9945796708426 19.5832387680786 34.4059205736066 1.75690655570668 0.813037461008438 0.136645651115239 1 0.468562 0.283994 0.491771 0.581803 GeneID:8630,Genbank:XM_011538926.1,HGNC:HGNC:23316,MIM:606623 hydroxysteroid 17-beta dehydrogenase 6 GO:0003824,GO:0004303,GO:0004745,GO:0005622,GO:0005783,GO:0006702,GO:0006710,GO:0009055,GO:0016491,GO:0031901,GO:0047035 catalytic activity|estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|intracellular|endoplasmic reticulum|androgen biosynthetic process|androgen catabolic process|electron transfer activity|oxidoreductase activity|early endosome membrane|testosterone dehydrogenase (NAD+) activity hsa00140,hsa00830 Steroid hormone biosynthesis|Retinol metabolism HSD17B7 272.423365395644 263.269119051307 281.577611739981 1.06954287975228 0.0969943237052644 0.641798069177235 1 5.54097 5.80119 6.53492 5.89818 GeneID:51478,Genbank:NM_016371.3,HGNC:HGNC:5215,MIM:606756 hydroxysteroid 17-beta dehydrogenase 7 GO:0000253,GO:0004303,GO:0005789,GO:0005886,GO:0006695,GO:0006703,GO:0016021 3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity|endoplasmic reticulum membrane|plasma membrane|cholesterol biosynthetic process|estrogen biosynthetic process|integral component of membrane hsa00100,hsa00140,hsa04913 Steroid biosynthesis|Steroid hormone biosynthesis|Ovarian steroidogenesis HSD17B8 4.71096848840498 6.51500704950053 2.90692992730943 0.446189836054327 -1.16427044468727 0.421606510161683 1 0.0481362 0.0427541 0 0 GeneID:7923,Genbank:NM_014234.4,HGNC:HGNC:3554,MIM:601417 hydroxysteroid 17-beta dehydrogenase 8 GO:0003857,GO:0004303,GO:0005740,GO:0005759,GO:0005886,GO:0006633,GO:0006703,GO:0008209,GO:0046949,GO:0047025,GO:0047035,GO:0051290,GO:0055114,GO:0070404 3-hydroxyacyl-CoA dehydrogenase activity|estradiol 17-beta-dehydrogenase activity|mitochondrial envelope|mitochondrial matrix|plasma membrane|fatty acid biosynthetic process|estrogen biosynthetic process|androgen metabolic process|fatty-acyl-CoA biosynthetic process|3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity|testosterone dehydrogenase (NAD+) activity|protein heterotetramerization|oxidation-reduction process|NADH binding hsa00140 Steroid hormone biosynthesis HSD3B2 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0.0200907 0 0 0.0354836 GeneID:3284,Genbank:NM_001166120.1,HGNC:HGNC:5218,MIM:613890 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 GO:0003854,GO:0004769,GO:0005743,GO:0005758,GO:0005783,GO:0005789,GO:0006694,GO:0006702,GO:0006704,GO:0006705,GO:0016021,GO:0030868,GO:0031966,GO:0102294 3-beta-hydroxy-delta5-steroid dehydrogenase activity|steroid delta-isomerase activity|mitochondrial inner membrane|mitochondrial intermembrane space|endoplasmic reticulum|endoplasmic reticulum membrane|steroid biosynthetic process|androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process|integral component of membrane|smooth endoplasmic reticulum membrane|mitochondrial membrane|cholesterol dehydrogenase activity hsa00140,hsa04913,hsa04925,hsa04927,hsa04934 Steroid hormone biosynthesis|Ovarian steroidogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome HSD3B7 188.942279698995 181.13126262292 196.753296775071 1.08624703392408 0.11935223766213 0.639623221364579 1 2.84867 3.4256 3.66109 3.51976 GeneID:80270,Genbank:XM_011545960.2,HGNC:HGNC:18324,MIM:607764 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 GO:0003854,GO:0005789,GO:0005811,GO:0006699,GO:0016021,GO:0035754,GO:0047016 3-beta-hydroxy-delta5-steroid dehydrogenase activity|endoplasmic reticulum membrane|lipid droplet|bile acid biosynthetic process|integral component of membrane|B cell chemotaxis|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity hsa00120 Primary bile acid biosynthesis HSDL1 632.522352253976 673.778138751323 591.266565756629 0.877538957931155 -0.188464920277596 0.25442525096911 1 7.40928 7.56371 7.04387 6.24638 GeneID:83693,Genbank:NM_001146051.1,HGNC:HGNC:16475 hydroxysteroid dehydrogenase like 1 GO:0005739 mitochondrion HSDL2 525.384631239011 425.575754646 625.193507832023 1.46905339650297 0.554886835288346 0.00128688067130525 0.119136883419797 4.15873 4.376 6.813 5.89468 GeneID:84263,Genbank:NM_032303.4,HGNC:HGNC:18572 hydroxysteroid dehydrogenase like 2 GO:0005739,GO:0005777,GO:0016020,GO:0016491 mitochondrion|peroxisome|membrane|oxidoreductase activity HSF1 1511.10490936654 1506.38642101066 1515.82339772243 1.00626464536598 0.00900978063656629 0.982825882872507 1 23.2467 25.0714 23.1517 25.5482 GeneID:3297,Genbank:NM_005526.3,HGNC:HGNC:5224,MIM:140580 heat shock transcription factor 1 GO:0000122,GO:0000165,GO:0000776,GO:0000777,GO:0000791,GO:0000792,GO:0000978,GO:0001078,GO:0001162,GO:0001892,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006281,GO:0006397,GO:0006952,GO:0007143,GO:0007283,GO:0008284,GO:0008285,GO:0009299,GO:0010667,GO:0014823,GO:0016605,GO:0019901,GO:0031072,GO:0031490,GO:0032720,GO:0033574,GO:0034605,GO:0034620,GO:0035865,GO:0040018,GO:0042531,GO:0042802,GO:0043280,GO:0043497,GO:0043565,GO:0043621,GO:0043623,GO:0045120,GO:0045931,GO:0045944,GO:0046982,GO:0048471,GO:0051028,GO:0051260,GO:0051879,GO:0060136,GO:0061408,GO:0061770,GO:0070207,GO:0070301,GO:0071222,GO:0071276,GO:0071280,GO:0071392,GO:0071480,GO:0072738,GO:0090084,GO:0090261,GO:0097165,GO:0097431,GO:0097677,GO:0098847,GO:1900034,GO:1900365,GO:1901215,GO:1902512,GO:1903936,GO:1904385,GO:1904528,GO:1904843,GO:1904845,GO:1990841,GO:1990904,GO:1990910,GO:1990911,GO:2001033 negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|kinetochore|condensed chromosome kinetochore|euchromatin|heterochromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|embryonic placenta development|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|DNA repair|mRNA processing|defense response|female meiotic nuclear division|spermatogenesis|positive regulation of cell proliferation|negative regulation of cell proliferation|mRNA transcription|negative regulation of cardiac muscle cell apoptotic process|response to activity|PML body|protein kinase binding|heat shock protein binding|chromatin DNA binding|negative regulation of tumor necrosis factor production|response to testosterone|cellular response to heat|cellular response to unfolded protein|cellular response to potassium ion|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of protein heterodimerization activity|sequence-specific DNA binding|protein self-association|cellular protein complex assembly|pronucleus|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|perinuclear region of cytoplasm|mRNA transport|protein homooligomerization|Hsp90 protein binding|embryonic process involved in female pregnancy|positive regulation of transcription from RNA polymerase II promoter in response to heat stress|translation elongation factor binding|protein homotrimerization|cellular response to hydrogen peroxide|cellular response to lipopolysaccharide|cellular response to cadmium ion|cellular response to copper ion|cellular response to estradiol stimulus|cellular response to gamma radiation|cellular response to diamide|negative regulation of inclusion body assembly|positive regulation of inclusion body assembly|nuclear stress granule|mitotic spindle pole|STAT family protein binding|sequence-specific single stranded DNA binding|regulation of cellular response to heat|positive regulation of mRNA polyadenylation|negative regulation of neuron death|positive regulation of apoptotic DNA fragmentation|cellular response to sodium arsenite|cellular response to angiotensin|positive regulation of microtubule binding|cellular response to nitroglycerin|cellular response to L-glutamine|promoter-specific chromatin binding|ribonucleoprotein complex|response to hypobaric hypoxia|response to psychosocial stress|negative regulation of double-strand break repair via nonhomologous end joining hsa05134 Legionellosis HSF2 483.807759001086 544.065138713494 423.550379288677 0.778492039188932 -0.361245808417182 0.0403673124999522 0.758464027333929 5.93453 6.35634 4.96875 4.9128 GeneID:3298,Genbank:NM_004506.3,HGNC:HGNC:5225,MIM:140581 heat shock transcription factor 2 HSF2BP 29.8722036690626 28.2506365241484 31.4937708139768 1.11479862717628 0.156783130942244 0.787771281431759 1 0.0877552 0.0661394 0.0657003 0.111228 GeneID:11077,Genbank:XM_017028269.1,HGNC:HGNC:5226,MIM:604554 heat shock transcription factor 2 binding protein GO:0005829,GO:0006366,GO:0007283 cytosol|transcription from RNA polymerase II promoter|spermatogenesis HSF4 32.2104139177749 35.3419588698682 29.0788689656817 0.822785999857911 -0.281410849040317 0.620333372726895 1 0.535365 0.249164 0.186257 0.219414 GeneID:3299,Genbank:NM_001538.3,HGNC:HGNC:5227,MIM:602438 heat shock transcription factor 4 HSFX1 1.53681553250261 2.10436443188427 0.969266633120943 0.460598277767435 -1.11841907815744 0.810667292257127 1 0.0752856 0.0221282 0 0.0218121 GeneID:100506164,Genbank:NM_016153.2,HGNC:HGNC:29603 heat shock transcription factor family, X-linked 1 GO:0003700,GO:0005634,GO:0005737,GO:0006351,GO:0043565 DNA binding transcription factor activity|nucleus|cytoplasm|transcription, DNA-templated|sequence-specific DNA binding HSFX3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:101928917,Genbank:NM_001323079.1,HGNC:HGNC:52395 heat shock transcription factor family, X-linked member 3 GO:0003700,GO:0005634,GO:0006351,GO:0043565 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|sequence-specific DNA binding HSFX4 2.24497296238439 3.03648096111406 1.45346496365472 0.478667570213071 -1.06290402828578 0.698606856036559 1 0 0 0 0 GeneID:101927685,Genbank:NM_001351114.1,HGNC:HGNC:52398 heat shock transcription factor family, X-linked member 4 GO:0003700,GO:0005634,GO:0006351,GO:0043565 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|sequence-specific DNA binding HSH2D 15.8844114829235 15.7685287568975 16.0002942089494 1.01469797567199 0.0210503738724464 1 1 0.0502382 0.0891985 0.105277 0.0328523 GeneID:84941,Genbank:NM_001291274.1,HGNC:HGNC:24920,MIM:608349 hematopoietic SH2 domain containing GO:0002903,GO:0005070,GO:0005634,GO:0005739,GO:0005829,GO:0007165,GO:0042110,GO:0051902 negative regulation of B cell apoptotic process|SH3/SH2 adaptor activity|nucleus|mitochondrion|cytosol|signal transduction|T cell activation|negative regulation of mitochondrial depolarization HSP90AA1 16756.2055824413 16641.8435686606 16870.567596222 1.01374391164162 0.019693249909071 0.886478544870146 1 128.686 117.977 143.775 110.27 GeneID:3320,Genbank:NM_001017963.2,HGNC:HGNC:5253,MIM:140571 heat shock protein 90 alpha family class A member 1 GO:0000086,GO:0000166,GO:0003723,GO:0004713,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006839,GO:0006898,GO:0006986,GO:0007004,GO:0007165,GO:0009408,GO:0009409,GO:0010389,GO:0016020,GO:0016887,GO:0019221,GO:0023026,GO:0030235,GO:0030911,GO:0031396,GO:0032587,GO:0034774,GO:0038096,GO:0038128,GO:0042026,GO:0042470,GO:0042802,GO:0042803,GO:0042826,GO:0043202,GO:0043209,GO:0043234,GO:0043254,GO:0043312,GO:0043335,GO:0045040,GO:0045429,GO:0046677,GO:0048010,GO:0050821,GO:0050999,GO:0051020,GO:0051082,GO:0051131,GO:0051186,GO:0051973,GO:0061684,GO:0070062,GO:0070182,GO:0071682,GO:0097110,GO:0097711,GO:0097718,GO:1900034,GO:1904813,GO:1905323,GO:1990782 G2/M transition of mitotic cell cycle|nucleotide binding|RNA binding|protein tyrosine kinase activity|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|mitochondrial transport|receptor-mediated endocytosis|response to unfolded protein|telomere maintenance via telomerase|signal transduction|response to heat|response to cold|regulation of G2/M transition of mitotic cell cycle|membrane|ATPase activity|cytokine-mediated signaling pathway|MHC class II protein complex binding|nitric-oxide synthase regulator activity|TPR domain binding|regulation of protein ubiquitination|ruffle membrane|secretory granule lumen|Fc-gamma receptor signaling pathway involved in phagocytosis|ERBB2 signaling pathway|protein refolding|melanosome|identical protein binding|protein homodimerization activity|histone deacetylase binding|lysosomal lumen|myelin sheath|protein complex|regulation of protein complex assembly|neutrophil degranulation|protein unfolding|protein import into mitochondrial outer membrane|positive regulation of nitric oxide biosynthetic process|response to antibiotic|vascular endothelial growth factor receptor signaling pathway|protein stabilization|regulation of nitric-oxide synthase activity|GTPase binding|unfolded protein binding|chaperone-mediated protein complex assembly|cofactor metabolic process|positive regulation of telomerase activity|chaperone-mediated autophagy|extracellular exosome|DNA polymerase binding|endocytic vesicle lumen|scaffold protein binding|ciliary basal body-plasma membrane docking|disordered domain specific binding|regulation of cellular response to heat|ficolin-1-rich granule lumen|telomerase holoenzyme complex assembly|protein tyrosine kinase binding hsa04141,hsa04151,hsa04217,hsa04612,hsa04621,hsa04657,hsa04659,hsa04914,hsa04915,hsa05200,hsa05215,hsa05418 Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Necroptosis|Antigen processing and presentation|NOD-like receptor signaling pathway|IL-17 signaling pathway|Th17 cell differentiation|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Pathways in cancer|Prostate cancer|Fluid shear stress and atherosclerosis HSP90AB1 46256.0340207559 49415.2849904196 43096.7830510922 0.872134665608983 -0.197377177309394 0.125312449495925 1 484.407 475.457 429.873 423.953 GeneID:3326,Genbank:NM_001271970.1,HGNC:HGNC:5258,MIM:140572 heat shock protein 90 alpha family class B member 1 GO:0001890,GO:0002134,GO:0002135,GO:0003723,GO:0003725,GO:0005524,GO:0005525,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005765,GO:0005829,GO:0006457,GO:0006805,GO:0006986,GO:0007004,GO:0009651,GO:0009986,GO:0016020,GO:0016234,GO:0016323,GO:0016324,GO:0017098,GO:0019062,GO:0019887,GO:0019900,GO:0019901,GO:0023026,GO:0030235,GO:0030511,GO:0030911,GO:0031072,GO:0031396,GO:0031526,GO:0032092,GO:0032435,GO:0032516,GO:0032564,GO:0033160,GO:0034751,GO:0034774,GO:0035690,GO:0038096,GO:0042220,GO:0042277,GO:0042470,GO:0042802,GO:0042803,GO:0042826,GO:0043008,GO:0043234,GO:0043312,GO:0043524,GO:0044325,GO:0045296,GO:0045429,GO:0045597,GO:0045793,GO:0046983,GO:0050821,GO:0051082,GO:0051131,GO:0051973,GO:0060334,GO:0060338,GO:0070062,GO:0070182,GO:0071157,GO:0071353,GO:0071407,GO:0071902,GO:0097435,GO:0097718,GO:1900034,GO:1901389,GO:1903660,GO:1904813,GO:1905323,GO:1990226,GO:1990913,GO:1990917,GO:2000010 placenta development|UTP binding|CTP binding|RNA binding|double-stranded RNA binding|ATP binding|GTP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|mitochondrion|lysosomal membrane|cytosol|protein folding|xenobiotic metabolic process|response to unfolded protein|telomere maintenance via telomerase|response to salt stress|cell surface|membrane|inclusion body|basolateral plasma membrane|apical plasma membrane|sulfonylurea receptor binding|virion attachment to host cell|protein kinase regulator activity|kinase binding|protein kinase binding|MHC class II protein complex binding|nitric-oxide synthase regulator activity|positive regulation of transforming growth factor beta receptor signaling pathway|TPR domain binding|heat shock protein binding|regulation of protein ubiquitination|brush border membrane|positive regulation of protein binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of phosphoprotein phosphatase activity|dATP binding|positive regulation of protein import into nucleus, translocation|aryl hydrocarbon receptor complex|secretory granule lumen|cellular response to drug|Fc-gamma receptor signaling pathway involved in phagocytosis|response to cocaine|peptide binding|melanosome|identical protein binding|protein homodimerization activity|histone deacetylase binding|ATP-dependent protein binding|protein complex|neutrophil degranulation|negative regulation of neuron apoptotic process|ion channel binding|cadherin binding|positive regulation of nitric oxide biosynthetic process|positive regulation of cell differentiation|positive regulation of cell size|protein dimerization activity|protein stabilization|unfolded protein binding|chaperone-mediated protein complex assembly|positive regulation of telomerase activity|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|extracellular exosome|DNA polymerase binding|negative regulation of cell cycle arrest|cellular response to interleukin-4|cellular response to organic cyclic compound|positive regulation of protein serine/threonine kinase activity|supramolecular fiber organization|disordered domain specific binding|regulation of cellular response to heat|negative regulation of transforming growth factor beta activation|negative regulation of complement-dependent cytotoxicity|ficolin-1-rich granule lumen|telomerase holoenzyme complex assembly|histone methyltransferase binding|sperm head plasma membrane|ooplasm|positive regulation of protein localization to cell surface hsa04141,hsa04151,hsa04217,hsa04612,hsa04621,hsa04657,hsa04659,hsa04914,hsa04915,hsa05200,hsa05215,hsa05418 Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|Necroptosis|Antigen processing and presentation|NOD-like receptor signaling pathway|IL-17 signaling pathway|Th17 cell differentiation|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Pathways in cancer|Prostate cancer|Fluid shear stress and atherosclerosis HSP90B1 7507.84259300925 7847.04794945243 7168.63723656607 0.913545741372245 -0.130451128269094 0.43546694345601 1 83.3286 73.2402 79.2127 64.2482 GeneID:7184,Genbank:NM_003299.2,HGNC:HGNC:12028,MIM:191175 heat shock protein 90 beta family member 1 GO:0001666,GO:0002224,GO:0003723,GO:0005509,GO:0005524,GO:0005576,GO:0005634,GO:0005783,GO:0005788,GO:0005789,GO:0005829,GO:0005886,GO:0005925,GO:0006898,GO:0015031,GO:0016020,GO:0019221,GO:0019903,GO:0030433,GO:0030496,GO:0030970,GO:0031012,GO:0031247,GO:0034663,GO:0034975,GO:0034976,GO:0036500,GO:0042470,GO:0043066,GO:0043234,GO:0043666,GO:0043687,GO:0044267,GO:0048471,GO:0050750,GO:0051082,GO:0051208,GO:0070062,GO:0071318,GO:0071682 response to hypoxia|toll-like receptor signaling pathway|RNA binding|calcium ion binding|ATP binding|extracellular region|nucleus|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|cytosol|plasma membrane|focal adhesion|receptor-mediated endocytosis|protein transport|membrane|cytokine-mediated signaling pathway|protein phosphatase binding|ubiquitin-dependent ERAD pathway|midbody|retrograde protein transport, ER to cytosol|extracellular matrix|actin rod assembly|endoplasmic reticulum chaperone complex|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|ATF6-mediated unfolded protein response|melanosome|negative regulation of apoptotic process|protein complex|regulation of phosphoprotein phosphatase activity|post-translational protein modification|cellular protein metabolic process|perinuclear region of cytoplasm|low-density lipoprotein particle receptor binding|unfolded protein binding|sequestering of calcium ion|extracellular exosome|cellular response to ATP|endocytic vesicle lumen hsa04141,hsa04151,hsa04657,hsa04915,hsa04918,hsa05200,hsa05215,hsa05418 Protein processing in endoplasmic reticulum|PI3K-Akt signaling pathway|IL-17 signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Pathways in cancer|Prostate cancer|Fluid shear stress and atherosclerosis HSPA12A 218.306615008747 223.352821429552 213.260408587942 0.954814034687298 -0.066708322325073 0.788523043075682 1 0.855284 0.735977 0.900885 0.647487 GeneID:259217,Genbank:XM_005269673.5,HGNC:HGNC:19022,MIM:610701 heat shock protein family A (Hsp70) member 12A GO:0005524,GO:0070062 ATP binding|extracellular exosome HSPA12B 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0153728 0 GeneID:116835,Genbank:NM_052970.4,HGNC:HGNC:16193,MIM:610702 heat shock protein family A (Hsp70) member 12B GO:0005524 ATP binding HSPA13 850.93219037986 870.646470164107 831.217910595614 0.954713467613254 -0.0668602841260519 0.808710243556054 1 10.2204 8.48296 10.1762 7.84388 GeneID:6782,Genbank:NM_006948.4,HGNC:HGNC:11375,MIM:601100 heat shock protein family A (Hsp70) member 13 GO:0005524,GO:0005783,GO:0043231,GO:0070062 ATP binding|endoplasmic reticulum|intracellular membrane-bounded organelle|extracellular exosome HSPA14 771.149700196299 837.1609696993 705.138430693299 0.842297307465944 -0.247598540575833 0.120505728479651 1 5.19377 5.60211 4.95401 4.53209 GeneID:51182,Genbank:NM_016299.3,HGNC:HGNC:29526,MIM:610369 heat shock protein family A (Hsp70) member 14 GO:0005524,GO:0005829,GO:0005840 ATP binding|cytosol|ribosome HSPA1A 62.4454548672377 61.8920584698277 62.9988512646477 1.01788263021434 0.0255712170424719 0.977913787426704 1 0.886785 0.943975 0.928659 0.980188 GeneID:3303,Genbank:NM_005345.5,HGNC:HGNC:5232,MIM:140550 heat shock protein family A (Hsp70) member 1A GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0042026,GO:0090063,GO:1901673 ATP binding|nucleus|cytoplasm|centrosome|protein refolding|positive regulation of microtubule nucleation|regulation of mitotic spindle assembly hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05020,hsa05134,hsa05145,hsa05162,hsa05164 Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Prion diseases|Legionellosis|Toxoplasmosis|Measles|Influenza A HSPA1B 1541.31629822927 1490.57865763333 1592.0539388252 1.06807777682326 0.0950167070925453 0.525574943608845 1 21.6516 22.3289 25.537 22.5523 GeneID:3304,Genbank:NM_005346.4,HGNC:HGNC:5233,MIM:603012 heat shock protein family A (Hsp70) member 1B GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0042026,GO:0090063,GO:1901673 ATP binding|nucleus|cytoplasm|centrosome|protein refolding|positive regulation of microtubule nucleation|regulation of mitotic spindle assembly hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05134,hsa05145,hsa05162,hsa05164 Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Legionellosis|Toxoplasmosis|Measles|Influenza A HSPA1L 10.2284077518165 10.2816907859967 10.1751247176364 0.989635355645455 -0.0150310520273937 1 1 0.113691 0.130053 0.0807539 0.124952 GeneID:3305,Genbank:NM_005527.3,HGNC:HGNC:5234,MIM:140559 heat shock protein family A (Hsp70) member 1 like hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05134,hsa05145,hsa05162,hsa05164 Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Legionellosis|Toxoplasmosis|Measles|Influenza A HSPA2 28.4412157253989 22.4756409051378 34.40679054566 1.5308480274658 0.614331068661393 0.259020041875654 1 0.284684 0.328711 0.461355 0.494219 GeneID:3306,Genbank:NM_021979.3,HGNC:HGNC:5235,MIM:140560 heat shock protein family A (Hsp70) member 2 hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05134,hsa05145,hsa05162,hsa05164 Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Legionellosis|Toxoplasmosis|Measles|Influenza A HSPA4 3203.02266158143 3410.78958394554 2995.25573921733 0.878170777029427 -0.187426568321105 0.313515283940727 1 34.0285 29.7764 31.7184 24.7122 GeneID:3308,Genbank:NM_002154.3,HGNC:HGNC:5237,MIM:601113 heat shock protein family A (Hsp70) member 4 GO:0005524,GO:0005829,GO:0006986,GO:0045040,GO:0051131,GO:0070062 ATP binding|cytosol|response to unfolded protein|protein import into mitochondrial outer membrane|chaperone-mediated protein complex assembly|extracellular exosome hsa04530,hsa04612 Tight junction|Antigen processing and presentation HSPA4L 272.840216386497 301.887690255714 243.792742517279 0.807561057924468 -0.308356751941873 0.1392541523736 1 1.9165 1.73596 1.72402 1.31138 GeneID:22824,Genbank:NM_001317381.1,HGNC:HGNC:17041 heat shock protein family A (Hsp70) member 4 like GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006457,GO:0006986 ATP binding|nucleus|cytoplasm|cytosol|protein folding|response to unfolded protein hsa04141 Protein processing in endoplasmic reticulum HSPA5 15857.5416619071 15935.4921343695 15779.5911894447 0.990216747395674 -0.0141837452839496 0.911197202286069 1 133.245 138.39 140.529 130.857 GeneID:3309,Genbank:NM_005347.4,HGNC:HGNC:5238,MIM:138120 heat shock protein family A (Hsp70) member 5 hsa03060,hsa04141,hsa04612,hsa04918,hsa05020 Protein export|Protein processing in endoplasmic reticulum|Antigen processing and presentation|Thyroid hormone synthesis|Prion diseases HSPA6 11.2914661385525 14.3463408257104 8.23659145139452 0.574124897174724 -0.800563474826563 0.365004027645445 1 0.237617 0.222463 0.0846194 0.157385 GeneID:3310,Genbank:NM_002155.4,HGNC:HGNC:5239,MIM:140555 heat shock protein family A (Hsp70) member 6 hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05134,hsa05145,hsa05162,hsa05164 Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Legionellosis|Toxoplasmosis|Measles|Influenza A HSPA8 40368.8062476306 39551.7773251234 41185.8351701378 1.04131439736784 0.0584057180546029 0.653551482190601 1 477.584 503.067 520.96 514.922 GeneID:3312,Genbank:XM_011542798.1,HGNC:HGNC:5241,MIM:600816 heat shock protein family A (Hsp70) member 8 GO:0000398,GO:0000974,GO:0001664,GO:0001786,GO:0003723,GO:0005524,GO:0005576,GO:0005615,GO:0005622,GO:0005634,GO:0005654,GO:0005681,GO:0005730,GO:0005765,GO:0005770,GO:0005829,GO:0005886,GO:0005925,GO:0006351,GO:0006457,GO:0006479,GO:0006986,GO:0007269,GO:0009267,GO:0016020,GO:0016032,GO:0016887,GO:0019221,GO:0019899,GO:0023026,GO:0030529,GO:0031012,GO:0031072,GO:0031625,GO:0031647,GO:0034774,GO:0042026,GO:0042470,GO:0042623,GO:0043202,GO:0043209,GO:0043254,GO:0043312,GO:0043488,GO:0044829,GO:0045296,GO:0045892,GO:0046034,GO:0048026,GO:0051082,GO:0051085,GO:0051726,GO:0055131,GO:0061024,GO:0061202,GO:0061635,GO:0061684,GO:0061738,GO:0061740,GO:0061741,GO:0070062,GO:0072318,GO:0072562,GO:0098575,GO:0098793,GO:1900034,GO:1902904,GO:1904589,GO:1904764,GO:1904813 mRNA splicing, via spliceosome|Prp19 complex|G-protein coupled receptor binding|phosphatidylserine binding|RNA binding|ATP binding|extracellular region|extracellular space|intracellular|nucleus|nucleoplasm|spliceosomal complex|nucleolus|lysosomal membrane|late endosome|cytosol|plasma membrane|focal adhesion|transcription, DNA-templated|protein folding|protein methylation|response to unfolded protein|neurotransmitter secretion|cellular response to starvation|membrane|viral process|ATPase activity|cytokine-mediated signaling pathway|enzyme binding|MHC class II protein complex binding|intracellular ribonucleoprotein complex|extracellular matrix|heat shock protein binding|ubiquitin protein ligase binding|regulation of protein stability|secretory granule lumen|protein refolding|melanosome|ATPase activity, coupled|lysosomal lumen|myelin sheath|regulation of protein complex assembly|neutrophil degranulation|regulation of mRNA stability|positive regulation by host of viral genome replication|cadherin binding|negative regulation of transcription, DNA-templated|ATP metabolic process|positive regulation of mRNA splicing, via spliceosome|unfolded protein binding|chaperone cofactor-dependent protein refolding|regulation of cell cycle|C3HC4-type RING finger domain binding|membrane organization|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|regulation of protein complex stability|chaperone-mediated autophagy|late endosomal microautophagy|protein targeting to lysosome involved in chaperone-mediated autophagy|chaperone-mediated protein transport involved in chaperone-mediated autophagy|extracellular exosome|clathrin coat disassembly|blood microparticle|lumenal side of lysosomal membrane|presynapse|regulation of cellular response to heat|negative regulation of supramolecular fiber organization|regulation of protein import|chaperone-mediated autophagy translocation complex disassembly|ficolin-1-rich granule lumen hsa03040,hsa04010,hsa04141,hsa04144,hsa04213,hsa04612,hsa04915,hsa05134,hsa05145,hsa05162,hsa05164 Spliceosome|MAPK signaling pathway|Protein processing in endoplasmic reticulum|Endocytosis|Longevity regulating pathway - multiple species|Antigen processing and presentation|Estrogen signaling pathway|Legionellosis|Toxoplasmosis|Measles|Influenza A HSPA9 13556.4958317222 14184.1180386548 12928.8736247896 0.911503527364591 -0.133679855626183 0.307098690154791 1 140.712 139.295 132.203 125.8 GeneID:3313,Genbank:NM_004134.6,HGNC:HGNC:5244,MIM:600548 heat shock protein family A (Hsp70) member 9 hsa03018,hsa05152 RNA degradation|Tuberculosis HSPB1 10589.4533365625 10858.7845534478 10320.1221196772 0.950393855673327 -0.0734025857881148 0.555791399257142 1 663.829 688.046 629.957 678.325 GeneID:3315,Genbank:NM_001540.4,HGNC:HGNC:5246,MIM:602195 heat shock protein family B (small) member 1 hsa04010,hsa04370,hsa05146 MAPK signaling pathway|VEGF signaling pathway|Amoebiasis HSPB11 748.807409113683 718.853882075437 778.760936151928 1.08333689998798 0.115481967192087 0.467295742838042 1 31.6995 28.3912 32.1132 34.6284 GeneID:51668,Genbank:NM_001316935.1,HGNC:HGNC:25019 heat shock protein family B (small) member 11 GO:0001501,GO:0005813,GO:0005929,GO:0007224,GO:0007507,GO:0030324,GO:0030992,GO:0035735,GO:0046872,GO:0070062,GO:0070986,GO:0097542 skeletal system development|centrosome|cilium|smoothened signaling pathway|heart development|lung development|intraciliary transport particle B|intraciliary transport involved in cilium assembly|metal ion binding|extracellular exosome|left/right axis specification|ciliary tip HSPB2 2.50445058799185 1.61429302992691 3.39460814605679 2.10284507405107 1.07234256422493 0.655791198576295 1 0.204458 0 0.245868 0.0573051 GeneID:3316,Genbank:NM_001541.3,HGNC:HGNC:5247,MIM:602179 heat shock protein family B (small) member 2 hsa05205 Proteoglycans in cancer HSPB3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0529555 GeneID:8988,Genbank:NM_006308.2,HGNC:HGNC:5248,MIM:604624 heat shock protein family B (small) member 3 GO:0005634,GO:0005737,GO:0006986 nucleus|cytoplasm|response to unfolded protein HSPB6 6.90810940820094 5.09281911831339 8.72339969808849 1.71288229474316 0.776426016206056 0.529074473684264 1 0.117821 0.0757106 0.161359 0.229334 GeneID:126393,Genbank:NM_144617.2,HGNC:HGNC:26511,MIM:610695 heat shock protein family B (small) member 6 GO:0005212,GO:0005576,GO:0005634,GO:0005737,GO:0006937,GO:0010667,GO:0042803,GO:0045766,GO:0051082,GO:0051087,GO:0061077 structural constituent of eye lens|extracellular region|nucleus|cytoplasm|regulation of muscle contraction|negative regulation of cardiac muscle cell apoptotic process|protein homodimerization activity|positive regulation of angiogenesis|unfolded protein binding|chaperone binding|chaperone-mediated protein folding HSPB7 6.96200875430947 6.169014471598 7.75500303702094 1.257089454519 0.330087315628776 0.824665117231071 1 0.0705063 0.0624828 0.0765407 0.0616276 GeneID:27129,Genbank:NM_001349682.1,HGNC:HGNC:5249,MIM:610692 heat shock protein family B (small) member 7 GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0006986,GO:0008016,GO:0008022,GO:0015030,GO:0015629,GO:0016235,GO:0031005 nucleus|nucleoplasm|cytoplasm|mitochondrion|response to unfolded protein|regulation of heart contraction|protein C-terminus binding|Cajal body|actin cytoskeleton|aggresome|filamin binding HSPB8 1350.7910230412 1264.18833824181 1437.3937078406 1.13700914994966 0.185243864198398 0.21007258622215 1 28.2659 29.4167 33.6721 33.1403 GeneID:26353,Genbank:NM_014365.2,HGNC:HGNC:30171,MIM:608014 heat shock protein family B (small) member 8 HSPBAP1 79.6253476345111 86.5583077011117 72.6923875679105 0.839808326878563 -0.251868002014679 0.463109808568077 1 0.51658 0.510674 0.389906 0.504192 GeneID:79663,Genbank:XM_017007179.1,HGNC:HGNC:16389,MIM:608263 HSPB1 associated protein 1 HSPBP1 1201.63957114588 1239.75241172884 1163.52673056291 0.938515399974392 -0.0915476766459142 0.53417158335752 1 22.8092 22.4828 20.4644 22.6424 GeneID:23640,Genbank:NM_001297600.1,HGNC:HGNC:24989,MIM:612939 HSPA (Hsp70) binding protein 1 GO:0004857,GO:0006457,GO:0031398,GO:0032436 enzyme inhibitor activity|protein folding|positive regulation of protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process hsa04141 Protein processing in endoplasmic reticulum HSPD1 6795.50373758273 7309.49106013589 6281.51641502956 0.859364402165749 -0.218658077936803 0.103740126812733 1 117.224 105.985 104.33 90.1584 GeneID:3329,Genbank:NM_199440.1,HGNC:HGNC:5261,MIM:118190 heat shock protein family D (Hsp60) member 1 hsa03018,hsa04940,hsa05134,hsa05152 RNA degradation|Type I diabetes mellitus|Legionellosis|Tuberculosis HSPE1 262.127623564261 266.939750238434 257.315496890089 0.963945971554448 -0.0529758081363246 0.812443970352582 1 184.786 177.942 162.738 162.615 GeneID:3336,Genbank:NM_002157.2,HGNC:HGNC:5269,MIM:600141 heat shock protein family E (Hsp10) member 1 GO:0005524,GO:0005739,GO:0005759,GO:0006986,GO:0046872,GO:0051082,GO:0051085,GO:0051087 ATP binding|mitochondrion|mitochondrial matrix|response to unfolded protein|metal ion binding|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding HSPG2 454.612096760229 469.14408314552 440.080110374937 0.93804894100824 -0.0922649001766067 0.587063140705302 1 1.08782 1.09627 1.17517 0.937769 GeneID:3339,Genbank:NM_005529.6,HGNC:HGNC:5273,MIM:142461 heparan sulfate proteoglycan 2 hsa04512,hsa05161,hsa05205 ECM-receptor interaction|Hepatitis B|Proteoglycans in cancer HSPH1 1926.23138166008 2112.88542252061 1739.57734079955 0.823318350468947 -0.280477713041766 0.270453374711055 1 14.3218 12.5736 13.0315 8.96021 GeneID:10808,Genbank:NM_001286505.1,HGNC:HGNC:16969,MIM:610703 heat shock protein family H (Hsp110) member 1 hsa04141 Protein processing in endoplasmic reticulum HTATIP2 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.0722868 0 0 GeneID:10553,Genbank:NM_006410.4,HGNC:HGNC:16637,MIM:605628 HIV-1 Tat interactive protein 2 HTATSF1 2065.75108495778 2252.47831983844 1879.02385007712 0.834202857149757 -0.261529841412649 0.0651855920864664 0.901277047586747 23.2241 22.3287 21.2241 17.6624 GeneID:27336,Genbank:NM_001163280.1,HGNC:HGNC:5276,MIM:300346 HIV-1 Tat specific factor 1 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005684,GO:0005686,GO:0006351,GO:0006357,GO:0019079,GO:0032784 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|U2-type spliceosomal complex|U2 snRNP|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|viral genome replication|regulation of DNA-templated transcription, elongation HTD2 1.50823428181664 1.07619535328461 1.94027321034868 1.80290056487129 0.850319830201774 0.866997324863217 1 0.284419 0.721475 0.396809 0.395379 GeneID:109703458,Genbank:NM_001348712.1,HGNC:HGNC:53111 hydroxyacyl-thioester dehydratase type 2 GO:0005730,GO:0005739,GO:0005759,GO:0006631,GO:0018812,GO:0046949 nucleolus|mitochondrion|mitochondrial matrix|fatty acid metabolic process|3-hydroxyacyl-CoA dehydratase activity|fatty-acyl-CoA biosynthetic process HTR1D 9.68944010312083 9.20549543271206 10.1733847735296 1.10514255836553 0.144232482721941 0.939716216376614 1 0.13393 0.152543 0.078994 0.206599 GeneID:3352,Genbank:NM_000864.4,HGNC:HGNC:5289,MIM:182133 5-hydroxytryptamine receptor 1D GO:0004993,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007193,GO:0007268,GO:0009636,GO:0014827,GO:0030594,GO:0040012,GO:0042310,GO:0050795,GO:0051378 G-protein coupled serotonin receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|chemical synaptic transmission|response to toxic substance|intestine smooth muscle contraction|neurotransmitter receptor activity|regulation of locomotion|vasoconstriction|regulation of behavior|serotonin binding hsa04024,hsa04080,hsa04726,hsa04742 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse|Taste transduction HTR2C 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.01052 0 GeneID:3358,Genbank:NM_001256760.2,HGNC:HGNC:5295,MIM:312861 5-hydroxytryptamine receptor 2C GO:0001587,GO:0001662,GO:0004993,GO:0005886,GO:0005887,GO:0006182,GO:0006874,GO:0007186,GO:0007200,GO:0007208,GO:0007210,GO:0007268,GO:0007626,GO:0007631,GO:0008144,GO:0010513,GO:0030594,GO:0031644,GO:0032098,GO:0042493,GO:0043397,GO:0045600,GO:0051209,GO:0051378,GO:0051482,GO:0070374,GO:0071886 Gq/11-coupled serotonin receptor activity|behavioral fear response|G-protein coupled serotonin receptor activity|plasma membrane|integral component of plasma membrane|cGMP biosynthetic process|cellular calcium ion homeostasis|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|phospholipase C-activating serotonin receptor signaling pathway|serotonin receptor signaling pathway|chemical synaptic transmission|locomotory behavior|feeding behavior|drug binding|positive regulation of phosphatidylinositol biosynthetic process|neurotransmitter receptor activity|regulation of neurological system process|regulation of appetite|response to drug|regulation of corticotropin-releasing hormone secretion|positive regulation of fat cell differentiation|release of sequestered calcium ion into cytosol|serotonin binding|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|positive regulation of ERK1 and ERK2 cascade|1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding hsa04020,hsa04080,hsa04540,hsa04726,hsa04750 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Gap junction|Serotonergic synapse|Inflammatory mediator regulation of TRP channels HTR3A 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0165256 0 0 GeneID:3359,Genbank:NM_213621.3,HGNC:HGNC:5297,MIM:182139 5-hydroxytryptamine receptor 3A GO:0004888,GO:0005737,GO:0005886,GO:0007268,GO:0022850,GO:0030054,GO:0030424,GO:0032154,GO:0032414,GO:0042220,GO:0043025,GO:0045211,GO:0045471,GO:0051378,GO:0071363,GO:1904602 transmembrane signaling receptor activity|cytoplasm|plasma membrane|chemical synaptic transmission|serotonin-gated cation-selective channel activity|cell junction|axon|cleavage furrow|positive regulation of ion transmembrane transporter activity|response to cocaine|neuronal cell body|postsynaptic membrane|response to ethanol|serotonin binding|cellular response to growth factor stimulus|serotonin-activated cation-selective channel complex hsa04726,hsa04742 Serotonergic synapse|Taste transduction HTR3B 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.00832666 0 0 GeneID:9177,Genbank:XM_024448767.1,HGNC:HGNC:5298,MIM:604654 5-hydroxytryptamine receptor 3B GO:0004888,GO:0005886,GO:0005887,GO:0007268,GO:0009986,GO:0022850,GO:0045211,GO:1904602 transmembrane signaling receptor activity|plasma membrane|integral component of plasma membrane|chemical synaptic transmission|cell surface|serotonin-gated cation-selective channel activity|postsynaptic membrane|serotonin-activated cation-selective channel complex hsa04726,hsa04742 Serotonergic synapse|Taste transduction HTR3C 0.729234031512454 0.490071401957362 0.968396661067546 1.97603177251261 0.982606144127986 1 1 0 0.0232447 0 0.0454503 GeneID:170572,Genbank:NM_130770.2,HGNC:HGNC:24003,MIM:610121 5-hydroxytryptamine receptor 3C GO:0004888,GO:0005886,GO:0007268,GO:0016021,GO:0022850 transmembrane signaling receptor activity|plasma membrane|chemical synaptic transmission|integral component of membrane|serotonin-gated cation-selective channel activity hsa04726,hsa04742 Serotonergic synapse|Taste transduction HTR5A 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00994829 0 0 0 GeneID:3361,Genbank:NM_024012.3,HGNC:HGNC:5300,MIM:601305 5-hydroxytryptamine receptor 5A GO:0004993,GO:0005791,GO:0005794,GO:0005886,GO:0005887,GO:0007186,GO:0007198,GO:0019933,GO:0021766,GO:0030425,GO:0030594,GO:0032355,GO:0043204,GO:0051378 G-protein coupled serotonin receptor activity|rough endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting serotonin receptor signaling pathway|cAMP-mediated signaling|hippocampus development|dendrite|neurotransmitter receptor activity|response to estradiol|perikaryon|serotonin binding hsa04020,hsa04080,hsa04726 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse HTR6 0.975139704544532 0.980142803914724 0.97013660517434 0.989791080748215 -0.0148040531050533 1 1 0 0.0340706 0.0363521 0 GeneID:3362,Genbank:NM_000871.2,HGNC:HGNC:5301,MIM:601109 5-hydroxytryptamine receptor 6 GO:0004969,GO:0004993,GO:0005886,GO:0005887,GO:0005929,GO:0007186,GO:0007187,GO:0007268,GO:0021795,GO:0030594,GO:0032008 histamine receptor activity|G-protein coupled serotonin receptor activity|plasma membrane|integral component of plasma membrane|cilium|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|chemical synaptic transmission|cerebral cortex cell migration|neurotransmitter receptor activity|positive regulation of TOR signaling hsa04020,hsa04024,hsa04080,hsa04726 Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse HTR7 370.505371497616 418.734372328813 322.27637066642 0.769643936498604 -0.377736934605633 0.0440015547870013 0.784836632957795 2.91666 3.2012 2.38581 2.37242 GeneID:3363,Genbank:XM_024447973.1,HGNC:HGNC:5302,MIM:182137 5-hydroxytryptamine receptor 7 GO:0004993,GO:0005886,GO:0005887,GO:0006939,GO:0007186,GO:0007187,GO:0007198,GO:0007268,GO:0007623,GO:0008015,GO:0030594,GO:0042310,GO:0051378 G-protein coupled serotonin receptor activity|plasma membrane|integral component of plasma membrane|smooth muscle contraction|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting serotonin receptor signaling pathway|chemical synaptic transmission|circadian rhythm|blood circulation|neurotransmitter receptor activity|vasoconstriction|serotonin binding hsa04014,hsa04020,hsa04080,hsa04726 Ras signaling pathway|Calcium signaling pathway|Neuroactive ligand-receptor interaction|Serotonergic synapse HTRA1 3008.86178431814 2784.40058571005 3233.32298292623 1.16122766225525 0.215650844734057 0.1158692148248 1 60.3071 62.0243 71.0144 72.7569 GeneID:5654,Genbank:NM_002775.4,HGNC:HGNC:9476,MIM:602194 HtrA serine peptidase 1 HTRA2 572.214413953185 565.81057684325 578.61825106312 1.02263597526106 0.0322926845286529 0.853218690716679 1 8.61517 8.44245 8.76136 8.90889 GeneID:27429,Genbank:NM_001321727.1,HGNC:HGNC:14348,MIM:606441 HtrA serine peptidase 2 hsa04210,hsa04215,hsa05012 Apoptosis|Apoptosis - multiple species|Parkinson disease HTRA3 8.74418660734236 9.253521707397 8.23485150728773 0.889915403851598 -0.168259896161716 0.928306683791258 1 0.0939152 0.122804 0.0436087 0.176793 GeneID:94031,Genbank:XM_011513596.3,HGNC:HGNC:30406,MIM:608785 HtrA serine peptidase 3 HTRA4 1.3182945185515 2.15239070656922 0.484198330533773 0.224958381884837 -2.15226997256519 0.648987732022175 1 0.0190745 0 0 0 GeneID:203100,Genbank:NM_153692.3,HGNC:HGNC:26909,MIM:610700 HtrA serine peptidase 4 GO:0001558,GO:0004175,GO:0004252,GO:0005520,GO:0005576,GO:0006508,GO:0030512 regulation of cell growth|endopeptidase activity|serine-type endopeptidase activity|insulin-like growth factor binding|extracellular region|proteolysis|negative regulation of transforming growth factor beta receptor signaling pathway HTT 3898.53860040899 3507.67390205735 4289.40329876063 1.22286262022384 0.290262336609062 0.0809628219216877 0.953456291101287 10.5779 10.4949 15.0457 11.3733 GeneID:3064,Genbank:NM_002111.8,HGNC:HGNC:4851,MIM:613004 huntingtin hsa05016 Huntington disease HUNK 37.9527519004786 25.0220504642945 50.8834533366626 2.03354450944263 1.0239965683016 0.0287670067467819 0.674571566700525 0.119266 0.130602 0.237313 0.271383 GeneID:30811,Genbank:NM_014586.1,HGNC:HGNC:13326,MIM:606532 hormonally up-regulated Neu-associated kinase GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007165,GO:0007275,GO:0035556 protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|signal transduction|multicellular organism development|intracellular signal transduction HUS1 557.797194475855 594.590519389787 521.003869561922 0.876239786158404 -0.190602372362675 0.25101038515197 1 6.24204 7.91682 7.38609 6.20206 GeneID:3364,Genbank:NM_004507.3,HGNC:HGNC:5309,MIM:603760 HUS1 checkpoint clamp component hsa04218 Cellular senescence HUS1B 1.74989846105683 1.07619535328461 2.42360156882906 2.25200895119282 1.17121256179462 0.729411591636508 1 0.135951 0 0.190727 0.118265 GeneID:135458,Genbank:NM_148959.3,HGNC:HGNC:16485,MIM:609713 HUS1 checkpoint clamp component B GO:0000724,GO:0005730,GO:0006289,GO:0030896,GO:0031573,GO:0033314,GO:0035861,GO:0044778 double-strand break repair via homologous recombination|nucleolus|nucleotide-excision repair|checkpoint clamp complex|intra-S DNA damage checkpoint|mitotic DNA replication checkpoint|site of double-strand break|meiotic DNA integrity checkpoint HUWE1 7031.21543437295 7257.62232212271 6804.80854662319 0.937608523094506 -0.092942410611109 0.475830844905179 1 11.566 11.8251 12.4907 9.8086 GeneID:10075,Genbank:NM_031407.6,HGNC:HGNC:30892,MIM:300697 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase GO:0000209,GO:0003677,GO:0003723,GO:0004842,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006284,GO:0006513,GO:0016020,GO:0016574,GO:0030154,GO:0034774,GO:0042787,GO:0043312,GO:0061630,GO:0070062,GO:1903955,GO:1904813 protein polyubiquitination|DNA binding|RNA binding|ubiquitin-protein transferase activity|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|base-excision repair|protein monoubiquitination|membrane|histone ubiquitination|cell differentiation|secretory granule lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|neutrophil degranulation|ubiquitin protein ligase activity|extracellular exosome|positive regulation of protein targeting to mitochondrion|ficolin-1-rich granule lumen hsa04120 Ubiquitin mediated proteolysis HVCN1 11.4759678164207 12.2900026685111 10.6619329643304 0.867528938105762 -0.205016212510169 0.855666411154488 1 0.10834 0.0553199 0.144693 0.0676591 GeneID:84329,Genbank:NM_001256413.1,HGNC:HGNC:28240,MIM:611227 hydrogen voltage gated channel 1 GO:0005886,GO:0005887,GO:0009268,GO:0010043,GO:0015992,GO:0016021,GO:0022843,GO:0030171,GO:0030667,GO:0034765,GO:0035036,GO:0035579,GO:0042802,GO:0043312,GO:0071294,GO:0071467 plasma membrane|integral component of plasma membrane|response to pH|response to zinc ion|proton transport|integral component of membrane|voltage-gated cation channel activity|voltage-gated proton channel activity|secretory granule membrane|regulation of ion transmembrane transport|sperm-egg recognition|specific granule membrane|identical protein binding|neutrophil degranulation|cellular response to zinc ion|cellular response to pH HYAL1 6.29004559064404 7.24520982488261 5.33488135640547 0.736332209190631 -0.441571284558082 0.772596816404554 1 0.0962795 0.0486812 0.0899915 0.0120002 GeneID:3373,Genbank:XM_011533669.2,HGNC:HGNC:5320,MIM:607071 hyaluronoglucosaminidase 1 hsa00531,hsa04142 Glycosaminoglycan degradation|Lysosome HYAL2 1498.76052763547 1476.34798666721 1521.17306860374 1.03036213842627 0.0431514864259688 0.788737940061802 1 24.5581 25.5765 25.7644 26.723 GeneID:8692,Genbank:NM_003773.4,HGNC:HGNC:5321,MIM:603551 hyaluronoglucosaminidase 2 hsa00531 Glycosaminoglycan degradation HYAL3 157.130471381495 135.920232129004 178.340710633987 1.31209833768325 0.391875849507378 0.116170399361276 1 3.23248 3.03876 4.35672 4.26362 GeneID:8372,Genbank:NM_001200032.1,HGNC:HGNC:5322,MIM:604038 hyaluronoglucosaminidase 3 GO:0001552,GO:0001669,GO:0002080,GO:0004415,GO:0005576,GO:0005764,GO:0005769,GO:0005783,GO:0005886,GO:0005975,GO:0006954,GO:0007341,GO:0009615,GO:0030214,GO:0031410,GO:0033906,GO:0046677,GO:0051216,GO:0071347,GO:0071356,GO:0071493,GO:0097225,GO:2000355,GO:2000368 ovarian follicle atresia|acrosomal vesicle|acrosomal membrane|hyalurononglucosaminidase activity|extracellular region|lysosome|early endosome|endoplasmic reticulum|plasma membrane|carbohydrate metabolic process|inflammatory response|penetration of zona pellucida|response to virus|hyaluronan catabolic process|cytoplasmic vesicle|hyaluronoglucuronidase activity|response to antibiotic|cartilage development|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to UV-B|sperm midpiece|negative regulation of ovarian follicle development|positive regulation of acrosomal vesicle exocytosis hsa00531 Glycosaminoglycan degradation HYAL4 1.83237905785133 3.18055978516888 0.484198330533773 0.15223682723765 -2.71561069500597 0.389970284790734 1 0.0670748 0.01268 0 0.0119563 GeneID:23553,Genbank:XM_017011911.1,HGNC:HGNC:5323,MIM:604510 hyaluronoglucosaminidase 4 GO:0004415,GO:0005975,GO:0006027,GO:0009986,GO:0016021,GO:0030207 hyalurononglucosaminidase activity|carbohydrate metabolic process|glycosaminoglycan catabolic process|cell surface|integral component of membrane|chondroitin sulfate catabolic process hsa00531 Glycosaminoglycan degradation HYI 452.354696255557 494.252377504077 410.457015007037 0.830460375486311 -0.268016761682474 0.128496022241132 1 6.78448 6.66434 5.41077 6.16033 GeneID:81888,Genbank:XM_006710937.3,HGNC:HGNC:26948 hydroxypyruvate isomerase (putative) GO:0008903 hydroxypyruvate isomerase activity hsa00630 Glyoxylate and dicarboxylate metabolism HYKK 48.2320399086064 46.0656947831373 50.3983850340754 1.09405459466823 0.129684732181547 0.74991948965019 1 0.417454 0.287144 0.299819 0.38146 GeneID:123688,Genbank:NM_001083612.1,HGNC:HGNC:34403,MIM:614681 hydroxylysine kinase GO:0005759,GO:0006554,GO:0047992 mitochondrial matrix|lysine catabolic process|hydroxylysine kinase activity hsa00310 Lysine degradation HYLS1 113.442955795259 107.669595604855 119.216315985662 1.10724216354618 0.146970786653737 0.61522933621493 1 1.4288 1.51542 1.53836 1.70043 GeneID:219844,Genbank:NM_145014.2,HGNC:HGNC:26558,MIM:610693 HYLS1, centriolar and ciliogenesis associated GO:0005634,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0005886,GO:0005929,GO:0060271 nucleus|cytoplasm|centrosome|centriole|cytosol|plasma membrane|cilium|cilium assembly HYOU1 7546.955394938 7325.72466368628 7768.18612618972 1.06039832000467 0.084606289649336 0.528875834631956 1 46.4192 47.9426 52.718 49.2117 GeneID:10525,Genbank:NM_001130991.2,HGNC:HGNC:16931,MIM:601746 hypoxia up-regulated 1 GO:0002931,GO:0005524,GO:0005576,GO:0005783,GO:0005788,GO:0005790,GO:0005925,GO:0006888,GO:0006898,GO:0016020,GO:0034663,GO:0034976,GO:0036498,GO:0051087,GO:0070062,GO:0071456,GO:0071682,GO:1903298,GO:1903382 response to ischemia|ATP binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|smooth endoplasmic reticulum|focal adhesion|ER to Golgi vesicle-mediated transport|receptor-mediated endocytosis|membrane|endoplasmic reticulum chaperone complex|response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|chaperone binding|extracellular exosome|cellular response to hypoxia|endocytic vesicle lumen|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway hsa04141 Protein processing in endoplasmic reticulum HYPK 1598.02881777442 1558.56126133389 1637.49637421495 1.0506461406679 0.0712768490675209 0.617810583037226 1 42.6036 42.5365 43.4484 45.3345 GeneID:25764,Genbank:NM_016400.3,HGNC:HGNC:18418,MIM:612784 huntingtin interacting protein K GO:0005654,GO:0005737,GO:0015630,GO:0043066,GO:0043234,GO:0047485,GO:0050821 nucleoplasm|cytoplasm|microtubule cytoskeleton|negative regulation of apoptotic process|protein complex|protein N-terminus binding|protein stabilization IAH1 679.258283532322 636.457293964264 722.059273100379 1.13449760093553 0.182053558219533 0.279039027267164 1 9.99477 11.5153 11.9606 12.534 GeneID:285148,Genbank:NM_001039613.2,HGNC:HGNC:27696 isoamyl acetate hydrolyzing esterase 1 (putative) GO:0016042,GO:0016787,GO:0070062 lipid catabolic process|hydrolase activity|extracellular exosome IARS 3931.08757011887 4132.93090401148 3729.24423622627 0.902324360808116 -0.148281958955491 0.284105067209809 1 29.2304 25.9734 26.202 24.3821 GeneID:3376,Genbank:NM_002161.5,HGNC:HGNC:5330,MIM:600709 isoleucyl-tRNA synthetase GO:0000049,GO:0001649,GO:0002161,GO:0004822,GO:0005524,GO:0005737,GO:0005829,GO:0006418,GO:0006428,GO:0016020,GO:0017101,GO:0051020,GO:0070062 tRNA binding|osteoblast differentiation|aminoacyl-tRNA editing activity|isoleucine-tRNA ligase activity|ATP binding|cytoplasm|cytosol|tRNA aminoacylation for protein translation|isoleucyl-tRNA aminoacylation|membrane|aminoacyl-tRNA synthetase multienzyme complex|GTPase binding|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis IARS2 2532.92975424606 2637.79178428479 2428.06772420733 0.920492564528051 -0.119522026937203 0.399475736021028 1 29.934 28.4162 28.5699 25.2193 GeneID:55699,Genbank:NM_018060.3,HGNC:HGNC:29685,MIM:612801 isoleucyl-tRNA synthetase 2, mitochondrial GO:0000049,GO:0002161,GO:0004822,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006418,GO:0006428 tRNA binding|aminoacyl-tRNA editing activity|isoleucine-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|cytosol|tRNA aminoacylation for protein translation|isoleucyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis IBA57 223.736091143234 225.986491883826 221.485690402643 0.980083758796093 -0.0290230464389749 0.875392204671892 1 1.10731 1.4397 1.27693 1.16356 GeneID:200205,Genbank:NM_001010867.3,HGNC:HGNC:27302,MIM:615316 IBA57, iron-sulfur cluster assembly GO:0003723,GO:0005739,GO:0005759,GO:0006783,GO:0016226,GO:0016740 RNA binding|mitochondrion|mitochondrial matrix|heme biosynthetic process|iron-sulfur cluster assembly|transferase activity IBSP 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0 0 0 0 GeneID:3381,Genbank:NM_004967.3,HGNC:HGNC:5341,MIM:147563 integrin binding sialoprotein GO:0001649,GO:0005178,GO:0005576,GO:0005615,GO:0007155,GO:0016020,GO:0030198,GO:0030282,GO:0031012,GO:0031982,GO:0045785,GO:0071363 osteoblast differentiation|integrin binding|extracellular region|extracellular space|cell adhesion|membrane|extracellular matrix organization|bone mineralization|extracellular matrix|vesicle|positive regulation of cell adhesion|cellular response to growth factor stimulus hsa04151,hsa04510,hsa04512,hsa05165 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Human papillomavirus infection IBTK 384.993443307391 420.039873399559 349.947013215223 0.833128079920021 -0.263389791299853 0.401384976731884 1 2.78808 2.23577 2.41301 1.75314 GeneID:25998,Genbank:NM_001300906.1,HGNC:HGNC:17853,MIM:606457 inhibitor of Bruton tyrosine kinase GO:0001933,GO:0005654,GO:0005737,GO:0016020,GO:0019901,GO:0030292,GO:0051209 negative regulation of protein phosphorylation|nucleoplasm|cytoplasm|membrane|protein kinase binding|protein tyrosine kinase inhibitor activity|release of sequestered calcium ion into cytosol ICA1 100.680622211731 89.402683563486 111.958560859976 1.25229530476535 0.324574805469239 0.274516518036281 1 0.498427 0.451295 0.630733 0.518547 GeneID:3382,Genbank:NM_001276478.1,HGNC:HGNC:5343,MIM:147625 islet cell autoantigen 1 GO:0000139,GO:0005737,GO:0005829,GO:0006836,GO:0019904,GO:0030054,GO:0030667,GO:0030672,GO:0043231,GO:0050796 Golgi membrane|cytoplasm|cytosol|neurotransmitter transport|protein domain specific binding|cell junction|secretory granule membrane|synaptic vesicle membrane|intracellular membrane-bounded organelle|regulation of insulin secretion hsa04940 Type I diabetes mellitus ICA1L 73.3513755461276 77.890909945042 68.8118411472132 0.88343866050307 -0.17879812678863 0.629873198933899 1 0.347949 0.277363 0.245251 0.285605 GeneID:130026,Genbank:NM_001288622.1,HGNC:HGNC:14442 islet cell autoantigen 1 like GO:0001669,GO:0007286,GO:0019904 acrosomal vesicle|spermatid development|protein domain specific binding ICAM1 120.345736379461 140.378901021305 100.312571737617 0.714584392724324 -0.484823690599095 0.0780673864858054 0.94157495521624 1.49251 1.43125 1.0523 1.13795 GeneID:3383,Genbank:NM_000201.2,HGNC:HGNC:5344,MIM:147840 intercellular adhesion molecule 1 hsa04064,hsa04514,hsa04650,hsa04668,hsa04670,hsa04933,hsa05143,hsa05144,hsa05150,hsa05164,hsa05166,hsa05167,hsa05169,hsa05323,hsa05416,hsa05418 NF-kappa B signaling pathway|Cell adhesion molecules (CAMs)|Natural killer cell mediated cytotoxicity|TNF signaling pathway|Leukocyte transendothelial migration|AGE-RAGE signaling pathway in diabetic complications|African trypanosomiasis|Malaria|Staphylococcus aureus infection|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Rheumatoid arthritis|Viral myocarditis|Fluid shear stress and atherosclerosis ICAM3 81.1249647498793 77.4586734728775 84.7912560268811 1.09466444783064 0.130488702119 0.753631213313296 1 0.899222 0.932363 0.851344 1.27176 GeneID:3385,Genbank:NM_001320605.1,HGNC:HGNC:5346,MIM:146631 intercellular adhesion molecule 3 hsa04514 Cell adhesion molecules (CAMs) ICAM5 76.4048921302999 70.9054488038 81.9043354567998 1.15512047153717 0.208043323178671 0.561182811955627 1 1.04194 1.31758 1.38227 1.17673 GeneID:7087,Genbank:XM_011528229.1,HGNC:HGNC:5348,MIM:601852 intercellular adhesion molecule 5 GO:0005178,GO:0005886,GO:0005887,GO:0006909,GO:0007155,GO:0030198,GO:0050776,GO:0098609 integrin binding|plasma membrane|integral component of plasma membrane|phagocytosis|cell adhesion|extracellular matrix organization|regulation of immune response|cell-cell adhesion ICE1 745.649041051234 786.077874036149 705.220208066318 0.897137842648257 -0.156598426769838 0.495276910925582 1 3.3062 2.8883 3.22713 2.37532 GeneID:23379,Genbank:NM_015325.2,HGNC:HGNC:29154 interactor of little elongation complex ELL subunit 1 GO:0005654,GO:0008023,GO:0015030,GO:0016604,GO:0031334,GO:0035327,GO:0035363,GO:0042795,GO:0042796,GO:0042803,GO:0045945,GO:0090316 nucleoplasm|transcription elongation factor complex|Cajal body|nuclear body|positive regulation of protein complex assembly|transcriptionally active chromatin|histone locus body|snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter|protein homodimerization activity|positive regulation of transcription from RNA polymerase III promoter|positive regulation of intracellular protein transport ICE2 402.953289136362 387.619742632074 418.28683564065 1.07911643715652 0.109850540678775 0.58773564251468 1 1.48655 1.42825 1.92057 1.3273 GeneID:79664,Genbank:NM_001018089.2,HGNC:HGNC:29885,MIM:610835 interactor of little elongation complex ELL subunit 2 GO:0005654,GO:0005829,GO:0008023,GO:0015030,GO:0016604,GO:0035327,GO:0035363,GO:0042795,GO:0042796,GO:0045945 nucleoplasm|cytosol|transcription elongation factor complex|Cajal body|nuclear body|transcriptionally active chromatin|histone locus body|snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter|positive regulation of transcription from RNA polymerase III promoter ICK 657.94525019783 661.553745666003 654.336754729656 0.989090847140346 -0.0158250575232182 0.982260732369197 1 3.79206 3.06406 4.12968 2.88323 GeneID:22858,Genbank:XM_017010490.1,HGNC:HGNC:21219,MIM:612325 intestinal cell kinase GO:0000287,GO:0001650,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005929,GO:0006468,GO:0007165,GO:0007275,GO:0010468,GO:0035556,GO:0035720,GO:0035721,GO:0036064,GO:0042073,GO:0060271,GO:0097542,GO:0097546 magnesium ion binding|fibrillar center|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|cilium|protein phosphorylation|signal transduction|multicellular organism development|regulation of gene expression|intracellular signal transduction|intraciliary anterograde transport|intraciliary retrograde transport|ciliary basal body|intraciliary transport|cilium assembly|ciliary tip|ciliary base ICMT 6217.55078444729 5345.90020377292 7089.20136512167 1.32610058079992 0.407190203744714 0.00212186381530285 0.164715617601136 46.252 49.3185 66.6689 62.1368 GeneID:23463,Genbank:NM_012405.3,HGNC:HGNC:5350,MIM:605851 isoprenylcysteine carboxyl methyltransferase GO:0003880,GO:0004671,GO:0005783,GO:0005789,GO:0006464,GO:0006481,GO:0006612,GO:0016020,GO:0016021,GO:0043687 protein C-terminal carboxyl O-methyltransferase activity|protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cellular protein modification process|C-terminal protein methylation|protein targeting to membrane|membrane|integral component of membrane|post-translational protein modification hsa00900 Terpenoid backbone biosynthesis ICOSLG 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0138868 GeneID:23308,Genbank:XM_011529516.3,HGNC:HGNC:17087,MIM:605717 inducible T cell costimulator ligand GO:0002250,GO:0005102,GO:0005886,GO:0006952,GO:0006972,GO:0007165,GO:0016021,GO:0031295,GO:0036464,GO:0042104,GO:0042110,GO:0042113,GO:0070062 adaptive immune response|receptor binding|plasma membrane|defense response|hyperosmotic response|signal transduction|integral component of membrane|T cell costimulation|cytoplasmic ribonucleoprotein granule|positive regulation of activated T cell proliferation|T cell activation|B cell activation|extracellular exosome hsa04514,hsa04672 Cell adhesion molecules (CAMs)|Intestinal immune network for IgA production ID1 3636.00041138085 3316.97661911788 3955.02420364382 1.19235817968944 0.253817680800064 0.0646889100797213 0.90091963811897 117.951 123.747 146.263 140.05 GeneID:3397,Genbank:NM_181353.2,HGNC:HGNC:5360,MIM:600349 inhibitor of DNA binding 1, HLH protein hsa04015,hsa04350,hsa04390,hsa04550 Rap1 signaling pathway|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells ID2 895.256578085506 808.602558216826 981.910597954185 1.21433031342313 0.280160906535036 0.0702575260091036 0.92021045003939 26.4429 26.2671 34.9297 29.3596 GeneID:3398,Genbank:NM_002166.4,HGNC:HGNC:5361,MIM:600386 inhibitor of DNA binding 2 GO:0000122,GO:0001656,GO:0001779,GO:0001966,GO:0003149,GO:0003166,GO:0005634,GO:0005737,GO:0005829,GO:0006351,GO:0007275,GO:0008344,GO:0010628,GO:0010629,GO:0014003,GO:0019216,GO:0021772,GO:0032922,GO:0033598,GO:0042752,GO:0043153,GO:0043234,GO:0043353,GO:0043392,GO:0043433,GO:0044325,GO:0045475,GO:0045578,GO:0045600,GO:0045648,GO:0045651,GO:0045665,GO:0045668,GO:0045777,GO:0045892,GO:0045893,GO:0046983,GO:0048469,GO:0048541,GO:0048557,GO:0048661,GO:0048663,GO:0048667,GO:0048711,GO:0048715,GO:0060612,GO:0060749,GO:0061030,GO:0061031,GO:0071158,GO:0071285,GO:0071931,GO:0090398,GO:2000045,GO:2000178 negative regulation of transcription from RNA polymerase II promoter|metanephros development|natural killer cell differentiation|thigmotaxis|membranous septum morphogenesis|bundle of His development|nucleus|cytoplasm|cytosol|transcription, DNA-templated|multicellular organism development|adult locomotory behavior|positive regulation of gene expression|negative regulation of gene expression|oligodendrocyte development|regulation of lipid metabolic process|olfactory bulb development|circadian regulation of gene expression|mammary gland epithelial cell proliferation|regulation of circadian rhythm|entrainment of circadian clock by photoperiod|protein complex|enucleate erythrocyte differentiation|negative regulation of DNA binding|negative regulation of DNA binding transcription factor activity|ion channel binding|locomotor rhythm|negative regulation of B cell differentiation|positive regulation of fat cell differentiation|positive regulation of erythrocyte differentiation|positive regulation of macrophage differentiation|negative regulation of neuron differentiation|negative regulation of osteoblast differentiation|positive regulation of blood pressure|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein dimerization activity|cell maturation|Peyer's patch development|embryonic digestive tract morphogenesis|positive regulation of smooth muscle cell proliferation|neuron fate commitment|cell morphogenesis involved in neuron differentiation|positive regulation of astrocyte differentiation|negative regulation of oligodendrocyte differentiation|adipose tissue development|mammary gland alveolus development|epithelial cell differentiation involved in mammary gland alveolus development|endodermal digestive tract morphogenesis|positive regulation of cell cycle arrest|cellular response to lithium ion|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|cellular senescence|regulation of G1/S transition of mitotic cell cycle|negative regulation of neural precursor cell proliferation hsa04350,hsa04390,hsa04550,hsa05202 TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer ID3 2397.47394040038 1936.30517468938 2858.64270611138 1.47633892811858 0.562023963799639 0.000192987836969761 0.0351237863284966 78.6726 80.8543 114.893 126.537 GeneID:3399,Genbank:NM_002167.4,HGNC:HGNC:5362,MIM:600277 inhibitor of DNA binding 3, HLH protein GO:0000122,GO:0001656,GO:0003700,GO:0003714,GO:0005634,GO:0005737,GO:0006275,GO:0006351,GO:0007275,GO:0007417,GO:0007507,GO:0007517,GO:0007623,GO:0008134,GO:0009611,GO:0019904,GO:0030182,GO:0030855,GO:0030903,GO:0042476,GO:0043065,GO:0043433,GO:0045662,GO:0045668,GO:0045892,GO:0046983,GO:0051726,GO:0072750,GO:1901707 negative regulation of transcription from RNA polymerase II promoter|metanephros development|DNA binding transcription factor activity|transcription corepressor activity|nucleus|cytoplasm|regulation of DNA replication|transcription, DNA-templated|multicellular organism development|central nervous system development|heart development|muscle organ development|circadian rhythm|transcription factor binding|response to wounding|protein domain specific binding|neuron differentiation|epithelial cell differentiation|notochord development|odontogenesis|positive regulation of apoptotic process|negative regulation of DNA binding transcription factor activity|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|protein dimerization activity|regulation of cell cycle|cellular response to leptomycin B|leptomycin B binding hsa04350,hsa04550 TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells ID4 176.146580914975 137.092480031658 215.200681798291 1.56974825861051 0.65053321187179 0.00640772881989417 0.31772812625209 1.914 1.92769 3.51002 2.58486 GeneID:3400,Genbank:NM_001546.3,HGNC:HGNC:5363,MIM:600581 inhibitor of DNA binding 4, HLH protein hsa04350,hsa04550 TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells IDE 655.192375884135 695.309820470414 615.074931297857 0.884605557392713 -0.176893789121831 0.6021406105864 1 3.67585 2.8736 3.36814 2.45478 GeneID:3416,Genbank:NM_001322794.1,HGNC:HGNC:5381,MIM:146680 insulin degrading enzyme GO:0001540,GO:0001618,GO:0004222,GO:0005102,GO:0005524,GO:0005615,GO:0005634,GO:0005737,GO:0005739,GO:0005777,GO:0005782,GO:0005829,GO:0005886,GO:0006508,GO:0008270,GO:0008286,GO:0008340,GO:0009986,GO:0010815,GO:0010992,GO:0016887,GO:0031597,GO:0031626,GO:0032461,GO:0042277,GO:0042447,GO:0042802,GO:0042803,GO:0043559,GO:0045732,GO:0045861,GO:0050435,GO:0051260,GO:0051289,GO:0051291,GO:0051603,GO:0097242,GO:0140036,GO:1901142,GO:1901143 amyloid-beta binding|virus receptor activity|metalloendopeptidase activity|receptor binding|ATP binding|extracellular space|nucleus|cytoplasm|mitochondrion|peroxisome|peroxisomal matrix|cytosol|plasma membrane|proteolysis|zinc ion binding|insulin receptor signaling pathway|determination of adult lifespan|cell surface|bradykinin catabolic process|ubiquitin recycling|ATPase activity|cytosolic proteasome complex|beta-endorphin binding|positive regulation of protein oligomerization|peptide binding|hormone catabolic process|identical protein binding|protein homodimerization activity|insulin binding|positive regulation of protein catabolic process|negative regulation of proteolysis|amyloid-beta metabolic process|protein homooligomerization|protein homotetramerization|protein heterooligomerization|proteolysis involved in cellular protein catabolic process|amyloid-beta clearance|ubiquitin-dependent protein binding|insulin metabolic process|insulin catabolic process hsa05010 Alzheimer disease IDH1 1750.95662274847 1778.12778171673 1723.78546378021 0.969438463031007 -0.044778771488403 0.765046317828544 1 21.9572 21.4308 21.1921 21.2416 GeneID:3417,Genbank:NM_005896.3,HGNC:HGNC:5382,MIM:147700 isocitrate dehydrogenase (NADP(+)) 1, cytosolic hsa00020,hsa00480,hsa04146,hsa05230 Citrate cycle (TCA cycle)|Glutathione metabolism|Peroxisome|Central carbon metabolism in cancer IDH2 1445.39491949067 1338.61154775443 1552.17829122692 1.15954347908529 0.213556917340265 0.149715941501041 1 19.8653 21.4054 23.4767 25.1258 GeneID:3418,Genbank:NM_001290114.1,HGNC:HGNC:5383,MIM:147650 isocitrate dehydrogenase (NADP(+)) 2, mitochondrial GO:0000287,GO:0004450,GO:0005739,GO:0005743,GO:0005759,GO:0005777,GO:0005829,GO:0005975,GO:0006097,GO:0006099,GO:0006102,GO:0006103,GO:0006741,GO:0007005,GO:0051287,GO:0060253,GO:0070062,GO:1903976,GO:1904465 magnesium ion binding|isocitrate dehydrogenase (NADP+) activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|peroxisome|cytosol|carbohydrate metabolic process|glyoxylate cycle|tricarboxylic acid cycle|isocitrate metabolic process|2-oxoglutarate metabolic process|NADP biosynthetic process|mitochondrion organization|NAD binding|negative regulation of glial cell proliferation|extracellular exosome|negative regulation of glial cell migration|negative regulation of matrix metallopeptidase secretion hsa00020,hsa00480,hsa04146 Citrate cycle (TCA cycle)|Glutathione metabolism|Peroxisome IDH3A 2489.38592820896 2503.74559386935 2475.02626254857 0.988529453075782 -0.0166441434262075 0.922902951898938 1 32.6151 31.4366 32.7893 30.8545 GeneID:3419,Genbank:XM_024449911.1,HGNC:HGNC:5384,MIM:601149 isocitrate dehydrogenase 3 (NAD(+)) alpha GO:0000287,GO:0004449,GO:0005634,GO:0005739,GO:0005759,GO:0005975,GO:0006099,GO:0043209,GO:0051287 magnesium ion binding|isocitrate dehydrogenase (NAD+) activity|nucleus|mitochondrion|mitochondrial matrix|carbohydrate metabolic process|tricarboxylic acid cycle|myelin sheath|NAD binding hsa00020 Citrate cycle (TCA cycle) IDH3B 2263.79358399007 2214.16955759407 2313.41761038607 1.04482405263482 0.0632600143032103 0.696284107604529 1 39.4037 41.4923 41.7026 45.3894 GeneID:3420,Genbank:NM_174855.3,HGNC:HGNC:5385,MIM:604526 isocitrate dehydrogenase 3 (NAD(+)) beta GO:0000287,GO:0004449,GO:0005634,GO:0005739,GO:0005759,GO:0006099,GO:0006102,GO:0009055,GO:0051287 magnesium ion binding|isocitrate dehydrogenase (NAD+) activity|nucleus|mitochondrion|mitochondrial matrix|tricarboxylic acid cycle|isocitrate metabolic process|electron transfer activity|NAD binding hsa00020 Citrate cycle (TCA cycle) IDH3G 2394.16821906761 2442.35748346001 2345.97895467521 0.960538729716067 -0.0580843091664467 0.658838594885054 1 44.6512 46.3241 43.0431 44.4143 GeneID:3421,Genbank:NM_004135.3,HGNC:HGNC:5386,MIM:300089 isocitrate dehydrogenase 3 (NAD(+)) gamma GO:0000287,GO:0004449,GO:0005524,GO:0005654,GO:0005730,GO:0005739,GO:0005759,GO:0005975,GO:0006099,GO:0006102,GO:0051287 magnesium ion binding|isocitrate dehydrogenase (NAD+) activity|ATP binding|nucleoplasm|nucleolus|mitochondrion|mitochondrial matrix|carbohydrate metabolic process|tricarboxylic acid cycle|isocitrate metabolic process|NAD binding hsa00020 Citrate cycle (TCA cycle) IDI1 980.346707569017 979.30703422884 981.386380909195 1.00212328371765 0.00306000341054808 0.971226918465559 1 6.65017 6.34006 6.7469 6.38497 GeneID:3422,Genbank:NM_001317955.1,HGNC:HGNC:5387,MIM:604055 isopentenyl-diphosphate delta isomerase 1 GO:0000287,GO:0004452,GO:0005777,GO:0005829,GO:0006695,GO:0008299,GO:0009240,GO:0016787,GO:0030145,GO:0045540,GO:0046872,GO:0050992 magnesium ion binding|isopentenyl-diphosphate delta-isomerase activity|peroxisome|cytosol|cholesterol biosynthetic process|isoprenoid biosynthetic process|isopentenyl diphosphate biosynthetic process|hydrolase activity|manganese ion binding|regulation of cholesterol biosynthetic process|metal ion binding|dimethylallyl diphosphate biosynthetic process hsa00900 Terpenoid backbone biosynthesis IDI2 5.61166600305323 7.83133377620985 3.3919982298966 0.433131612931742 -1.20712262080692 0.377851018385326 1 0.245359 0.141211 0.0582163 0.108462 GeneID:91734,Genbank:NM_033261.2,HGNC:HGNC:23487,MIM:615389 isopentenyl-diphosphate delta isomerase 2 GO:0004452,GO:0005777,GO:0005829,GO:0006695,GO:0008299,GO:0009240,GO:0016787,GO:0046490,GO:0046872,GO:0050992 isopentenyl-diphosphate delta-isomerase activity|peroxisome|cytosol|cholesterol biosynthetic process|isoprenoid biosynthetic process|isopentenyl diphosphate biosynthetic process|hydrolase activity|isopentenyl diphosphate metabolic process|metal ion binding|dimethylallyl diphosphate biosynthetic process hsa00900 Terpenoid backbone biosynthesis IDNK 40.2955671897092 43.2791538505559 37.3119805288626 0.862123614008304 -0.214033352567341 0.663401438024714 1 0.185871 0.12637 0.134986 0.160157 GeneID:414328,Genbank:XM_017014722.1,HGNC:HGNC:31367,MIM:611343 IDNK, gluconokinase GO:0005524,GO:0046177,GO:0046316 ATP binding|D-gluconate catabolic process|gluconokinase activity hsa00030 Pentose phosphate pathway IDO1 28.6776585521924 20.5153552973084 36.8399618070764 1.79572623886801 0.844567425840956 0.113932206000666 1 0.37747 0.420808 0.810867 0.542223 GeneID:3620,Genbank:NM_002164.5,HGNC:HGNC:6059,MIM:147435 indoleamine 2,3-dioxygenase 1 hsa00380,hsa05143 Tryptophan metabolism|African trypanosomiasis IDO2 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:169355,Genbank:NM_194294.2,HGNC:HGNC:27269,MIM:612129 indoleamine 2,3-dioxygenase 2 hsa00380,hsa05143 Tryptophan metabolism|African trypanosomiasis IDS 6381.5188574958 6225.56580492269 6537.47191006892 1.05010084463321 0.070527881287736 0.706617113549103 1 33.8154 32.868 41.0582 29.5235 GeneID:3423,Genbank:NM_001166550.3,HGNC:HGNC:5389,MIM:300823 iduronate 2-sulfatase GO:0004423,GO:0006027,GO:0030207,GO:0043202,GO:0046872 iduronate-2-sulfatase activity|glycosaminoglycan catabolic process|chondroitin sulfate catabolic process|lysosomal lumen|metal ion binding hsa00531,hsa04142 Glycosaminoglycan degradation|Lysosome IDUA 198.514569941672 191.547223577863 205.48191630548 1.07274807991123 0.101311318839709 0.673290162940796 1 1.85134 1.59434 2.25568 1.63396 GeneID:3425,Genbank:NM_000203.4,HGNC:HGNC:5391,MIM:252800 iduronidase, alpha-L- GO:0003940,GO:0005102,GO:0005984,GO:0006027,GO:0030135,GO:0030207,GO:0030209,GO:0043202,GO:0070062 L-iduronidase activity|receptor binding|disaccharide metabolic process|glycosaminoglycan catabolic process|coated vesicle|chondroitin sulfate catabolic process|dermatan sulfate catabolic process|lysosomal lumen|extracellular exosome hsa00531,hsa04142 Glycosaminoglycan degradation|Lysosome IER2 1425.6886487526 1256.02183754366 1595.35545996155 1.27016538429101 0.345016358070029 0.0195604457843074 0.571679014017276 37.3483 40.2273 49.7782 50.715 GeneID:9592,Genbank:NM_004907.2,HGNC:HGNC:28871 immediate early response 2 GO:0000977,GO:0001228,GO:0003677,GO:0005634,GO:0005654,GO:0005737,GO:0030182,GO:0045944,GO:0048870,GO:0071774 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|nucleus|nucleoplasm|cytoplasm|neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|cell motility|response to fibroblast growth factor IER3 166.553787170735 169.321522701258 163.786051640211 0.967307930068562 -0.0479528686135425 0.843209285299226 1 6.86166 7.42233 6.15607 7.79229 GeneID:8870,Genbank:NM_003897.3,HGNC:HGNC:5392,MIM:602996 immediate early response 3 IER3IP1 489.956191911875 489.456507688126 490.455876135624 1.00204179213434 0.00294268023732712 0.97797453042195 1 17.5014 16.799 18.7102 17.0374 GeneID:51124,Genbank:NM_016097.4,HGNC:HGNC:18550,MIM:609382 immediate early response 3 interacting protein 1 GO:0005783,GO:0005789,GO:0005794,GO:0006888,GO:0016020,GO:0030134,GO:0030173,GO:2000269 endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|ER to Golgi vesicle-mediated transport|membrane|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|regulation of fibroblast apoptotic process IER5 1063.620326178 1049.51272322344 1077.72792913256 1.02688410086394 0.0382733612623506 0.834383044152852 1 26.137 27.5489 25.9659 29.7231 GeneID:51278,Genbank:NM_016545.4,HGNC:HGNC:5393,MIM:607177 immediate early response 5 GO:0005634,GO:0005737,GO:0006351,GO:0034605,GO:0042127,GO:0042802,GO:0045944,GO:1900036 nucleus|cytoplasm|transcription, DNA-templated|cellular response to heat|regulation of cell proliferation|identical protein binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of cellular response to heat IER5L 1394.26159666829 1352.17965953007 1436.34353380651 1.06224311516835 0.0871139929854789 0.595090593432028 1 34.7814 36.9479 36.7419 40.1086 GeneID:389792,Genbank:NM_203434.2,HGNC:HGNC:23679 immediate early response 5 like IFFO1 376.482982778305 361.397035300656 391.568930255953 1.08348683582918 0.115681625051949 0.544400354368575 1 3.08803 3.43682 3.78849 3.8299 GeneID:25900,Genbank:NM_001330324.1,HGNC:HGNC:24970,MIM:610495 intermediate filament family orphan 1 GO:0005198,GO:0005882 structural molecule activity|intermediate filament IFFO2 2470.61523994207 2622.26745490473 2318.9630249794 0.884335051576061 -0.177335022028441 0.193615673458045 1 17.507 18.5426 16.8707 15.8802 GeneID:126917,Genbank:XM_011540630.2,HGNC:HGNC:27006 intermediate filament family orphan 2 GO:0005198,GO:0005882 structural molecule activity|intermediate filament IFI16 713.357562414912 584.104880848234 842.610243981589 1.44256668897879 0.528638015324863 0.473356805937989 1 3.67536 2.96106 7.06333 2.526 GeneID:3428,Genbank:XM_005245127.4,HGNC:HGNC:5395,MIM:147586 interferon gamma inducible protein 16 GO:0000122,GO:0000978,GO:0001047,GO:0001078,GO:0001819,GO:0002218,GO:0003690,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006351,GO:0006914,GO:0006954,GO:0008134,GO:0008283,GO:0010506,GO:0016020,GO:0016607,GO:0030097,GO:0030099,GO:0030224,GO:0032481,GO:0032731,GO:0040029,GO:0042149,GO:0042771,GO:0042802,GO:0043392,GO:0045071,GO:0045087,GO:0045824,GO:0045892,GO:0045944,GO:0051607,GO:0071479,GO:0072332,GO:0097202,GO:2000117 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|core promoter binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|positive regulation of cytokine production|activation of innate immune response|double-stranded DNA binding|RNA binding|nucleus|nucleoplasm|nucleolus|cytosol|transcription, DNA-templated|autophagy|inflammatory response|transcription factor binding|cell proliferation|regulation of autophagy|membrane|nuclear speck|hemopoiesis|myeloid cell differentiation|monocyte differentiation|positive regulation of type I interferon production|positive regulation of interleukin-1 beta production|regulation of gene expression, epigenetic|cellular response to glucose starvation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|negative regulation of DNA binding|negative regulation of viral genome replication|innate immune response|negative regulation of innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|defense response to virus|cellular response to ionizing radiation|intrinsic apoptotic signaling pathway by p53 class mediator|activation of cysteine-type endopeptidase activity|negative regulation of cysteine-type endopeptidase activity hsa04621 NOD-like receptor signaling pathway IFI27 1540.64721668499 1494.96089128648 1586.33354208351 1.0611204288551 0.0855884001287115 0.902864013532732 1 70.2552 75.153 113.032 45.6513 GeneID:3429,Genbank:NM_001288954.1,HGNC:HGNC:5397,MIM:600009 interferon alpha inducible protein 27 GO:0000122,GO:0001102,GO:0005521,GO:0005637,GO:0005739,GO:0005741,GO:0006919,GO:0016021,GO:0046825,GO:0060337,GO:0097190 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II activating transcription factor binding|lamin binding|nuclear inner membrane|mitochondrion|mitochondrial outer membrane|activation of cysteine-type endopeptidase activity involved in apoptotic process|integral component of membrane|regulation of protein export from nucleus|type I interferon signaling pathway|apoptotic signaling pathway IFI27L1 432.243225277869 398.324878235982 466.161572319756 1.17030493898396 0.226884492748466 0.296771704470288 1 0.911191 0.801588 1.05464 0.984496 GeneID:122509,Genbank:NM_145249.2,HGNC:HGNC:19754,MIM:611320 interferon alpha inducible protein 27 like 1 GO:0016021 integral component of membrane IFI27L2 439.306339514288 420.694657936642 457.918021091934 1.08848071268093 0.122315843937596 0.592174507095898 1 59.0631 57.7563 54.6978 72.7375 GeneID:83982,Genbank:NM_032036.2,HGNC:HGNC:19753,MIM:611319 interferon alpha inducible protein 27 like 2 GO:0016021 integral component of membrane IFI30 406.968428761175 433.522758281796 380.414099240555 0.877495107173314 -0.188537013773839 0.302124238665635 1 19.3041 19.1289 16.2089 17.4065 GeneID:10437,Genbank:NM_006332.4,HGNC:HGNC:5398,MIM:604664 IFI30, lysosomal thiol reductase GO:0005576,GO:0005764,GO:0005829,GO:0016667,GO:0019886,GO:0030054,GO:0042590,GO:0043202,GO:0043231,GO:0060333 extracellular region|lysosome|cytosol|oxidoreductase activity, acting on a sulfur group of donors|antigen processing and presentation of exogenous peptide antigen via MHC class II|cell junction|antigen processing and presentation of exogenous peptide antigen via MHC class I|lysosomal lumen|intracellular membrane-bounded organelle|interferon-gamma-mediated signaling pathway hsa04612 Antigen processing and presentation IFI35 721.039575807019 485.498735853745 956.580415760293 1.97030464781367 0.978418715930128 0.294020278111022 1 8.24334 8.81663 26.2621 9.00628 GeneID:3430,Genbank:NM_005533.4,HGNC:HGNC:5399,MIM:600735 interferon induced protein 35 GO:0005634,GO:0005829,GO:0060337 nucleus|cytosol|type I interferon signaling pathway IFI44 839.379314925836 449.002112389729 1229.75651746194 2.7388657726281 1.45357856363039 0.333962281049298 1 5.22229 4.89592 23.7927 4.67884 GeneID:10561,Genbank:XM_011540516.3,HGNC:HGNC:16938,MIM:610468 interferon induced protein 44 GO:0005737,GO:0009615 cytoplasm|response to virus IFI44L 587.12615882431 247.432946709509 926.819370939111 3.74573953575881 1.90525058363499 0.374512996940361 1 1.51029 1.34697 9.97285 0.92657 GeneID:10964,Genbank:NM_006820.3,HGNC:HGNC:17817,MIM:613975 interferon induced protein 44 like GO:0005525,GO:0005737,GO:0051607 GTP binding|cytoplasm|defense response to virus IFI6 2877.80386735716 2124.65425517356 3630.95347954075 1.70896204438878 0.773120355480902 0.518407415391705 1 80.3113 99.9076 274.697 55.7664 GeneID:2537,Genbank:XM_024446207.1,HGNC:HGNC:4054,MIM:147572 interferon alpha inducible protein 6 GO:0001836,GO:0005739,GO:0005886,GO:0006955,GO:0016021,GO:0043154,GO:0051902,GO:0060337,GO:2001240 release of cytochrome c from mitochondria|mitochondrion|plasma membrane|immune response|integral component of membrane|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of mitochondrial depolarization|type I interferon signaling pathway|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IFIH1 279.427287006084 179.151359704875 379.703214307293 2.11945482821229 1.08369321866544 0.455863067305717 1 1.47267 1.50144 5.44183 0.866273 GeneID:64135,Genbank:NM_022168.3,HGNC:HGNC:18873,MIM:606951 interferon induced with helicase C domain 1 GO:0003677,GO:0003725,GO:0003727,GO:0004386,GO:0005524,GO:0005634,GO:0005829,GO:0008270,GO:0009597,GO:0009615,GO:0016032,GO:0016579,GO:0016925,GO:0032480,GO:0032727,GO:0032728,GO:0034344,GO:0035549,GO:0039528,GO:0039530,GO:0042802,GO:0043021,GO:0045087,GO:0051607,GO:0060760,GO:0071360,GO:1902741,GO:1904469,GO:2000778 DNA binding|double-stranded RNA binding|single-stranded RNA binding|helicase activity|ATP binding|nucleus|cytosol|zinc ion binding|detection of virus|response to virus|viral process|protein deubiquitination|protein sumoylation|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of type III interferon production|positive regulation of interferon-beta secretion|cytoplasmic pattern recognition receptor signaling pathway in response to virus|MDA-5 signaling pathway|identical protein binding|ribonucleoprotein complex binding|innate immune response|defense response to virus|positive regulation of response to cytokine stimulus|cellular response to exogenous dsRNA|positive regulation of interferon-alpha secretion|positive regulation of tumor necrosis factor secretion|positive regulation of interleukin-6 secretion hsa04622,hsa05161,hsa05162,hsa05164,hsa05168 RIG-I-like receptor signaling pathway|Hepatitis B|Measles|Influenza A|Herpes simplex infection IFIT1 2782.50778042326 1052.28843850006 4512.72712234646 4.28848874247726 2.10046933353999 0.325355510192915 1 7.19256 7.49899 59.9041 6.42383 GeneID:3434,Genbank:NM_001270930.1,HGNC:HGNC:5407,MIM:147690 interferon induced protein with tetratricopeptide repeats 1 GO:0003723,GO:0005737,GO:0005829,GO:0009615,GO:0016032,GO:0019060,GO:0032091,GO:0043657,GO:0045070,GO:0045071,GO:0050689,GO:0051097,GO:0051607,GO:0060337,GO:0071357,GO:0071360 RNA binding|cytoplasm|cytosol|response to virus|viral process|intracellular transport of viral protein in host cell|negative regulation of protein binding|host cell|positive regulation of viral genome replication|negative regulation of viral genome replication|negative regulation of defense response to virus by host|negative regulation of helicase activity|defense response to virus|type I interferon signaling pathway|cellular response to type I interferon|cellular response to exogenous dsRNA hsa05160,hsa05168 Hepatitis C|Herpes simplex infection IFIT1B 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0 0 GeneID:439996,Genbank:NM_001010987.2,HGNC:HGNC:23442 interferon induced protein with tetratricopeptide repeats 1B GO:0051607 defense response to virus hsa05160,hsa05168 Hepatitis C|Herpes simplex infection IFIT2 280.114026585845 188.837117884436 371.390935287253 1.96672634833654 0.975796233995384 0.312518212801606 1 1.98805 1.82813 5.80685 1.86556 GeneID:3433,Genbank:NM_001547.4,HGNC:HGNC:5409,MIM:147040 interferon induced protein with tetratricopeptide repeats 2 GO:0003723,GO:0005737,GO:0005783,GO:0005829,GO:0008637,GO:0009615,GO:0032091,GO:0035457,GO:0043065,GO:0051607,GO:0060337 RNA binding|cytoplasm|endoplasmic reticulum|cytosol|apoptotic mitochondrial changes|response to virus|negative regulation of protein binding|cellular response to interferon-alpha|positive regulation of apoptotic process|defense response to virus|type I interferon signaling pathway IFIT3 1118.6202172145 539.817175229294 1697.42325919971 3.14444100167563 1.65280356693281 0.394639878598662 1 6.65104 5.8744 37.3896 4.01047 GeneID:3437,Genbank:NM_001289758.1,HGNC:HGNC:5411,MIM:604650 interferon induced protein with tetratricopeptide repeats 3 GO:0005737,GO:0005739,GO:0005829,GO:0008285,GO:0009615,GO:0035457,GO:0042802,GO:0043066,GO:0051607,GO:0060337 cytoplasm|mitochondrion|cytosol|negative regulation of cell proliferation|response to virus|cellular response to interferon-alpha|identical protein binding|negative regulation of apoptotic process|defense response to virus|type I interferon signaling pathway IFIT5 756.376711369321 593.916117542489 918.837305196154 1.54708262338144 0.629550247310289 0.531063029593598 1 6.73322 6.07766 16.0266 4.28256 GeneID:24138,Genbank:NM_012420.2,HGNC:HGNC:13328,MIM:616135 interferon induced protein with tetratricopeptide repeats 5 GO:0000049,GO:0000339,GO:0003690,GO:0003723,GO:0003727,GO:0005886,GO:0008266,GO:0015629,GO:0032587,GO:0043123,GO:0043231,GO:0045071,GO:0045087,GO:0045177,GO:0051607 tRNA binding|RNA cap binding|double-stranded DNA binding|RNA binding|single-stranded RNA binding|plasma membrane|poly(U) RNA binding|actin cytoskeleton|ruffle membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|negative regulation of viral genome replication|innate immune response|apical part of cell|defense response to virus IFITM1 776.701709179478 538.95371928582 1014.44969907314 1.88225753487221 0.912464034476682 0.487763381510903 1 32.5969 34.0245 108.38 21.5863 GeneID:8519,Genbank:NM_003641.3,HGNC:HGNC:5412,MIM:604456 interferon induced transmembrane protein 1 GO:0001503,GO:0005057,GO:0005886,GO:0007166,GO:0008285,GO:0009615,GO:0016020,GO:0016021,GO:0030336,GO:0034341,GO:0035455,GO:0035456,GO:0045071,GO:0045669,GO:0046597,GO:0050776,GO:0051607,GO:0060337 ossification|signal transducer activity, downstream of receptor|plasma membrane|cell surface receptor signaling pathway|negative regulation of cell proliferation|response to virus|membrane|integral component of membrane|negative regulation of cell migration|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|negative regulation of viral genome replication|positive regulation of osteoblast differentiation|negative regulation of viral entry into host cell|regulation of immune response|defense response to virus|type I interferon signaling pathway hsa04662 B cell receptor signaling pathway IFITM10 212.228293972389 191.364927134232 233.091660810546 1.21804796887909 0.284570950240356 0.216462388969362 1 1.74855 2.11144 2.21276 2.53733 GeneID:402778,Genbank:NM_001170820.3,HGNC:HGNC:40022 interferon induced transmembrane protein 10 GO:0005886,GO:0009607,GO:0016021 plasma membrane|response to biotic stimulus|integral component of membrane IFITM2 74.6558180143858 90.190721268661 59.1209147601105 0.655509945241491 -0.609310426047141 0.0707183495848955 0.923837754446726 6.07118 6.08658 3.89815 4.16367 GeneID:10581,Genbank:NM_006435.2,HGNC:HGNC:5413,MIM:605578 interferon induced transmembrane protein 2 GO:0005886,GO:0006955,GO:0009615,GO:0016021,GO:0034341,GO:0035455,GO:0035456,GO:0045071,GO:0046597,GO:0051607,GO:0060337 plasma membrane|immune response|response to virus|integral component of membrane|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|negative regulation of viral genome replication|negative regulation of viral entry into host cell|defense response to virus|type I interferon signaling pathway IFITM3 2210.55574023026 1940.64817372209 2480.46330673843 1.27816228635662 0.354071024749477 0.425436572832651 1 145.395 149.215 251.554 136.18 GeneID:10410,Genbank:NM_021034.2,HGNC:HGNC:5414,MIM:605579 interferon induced transmembrane protein 3 GO:0005765,GO:0005886,GO:0006955,GO:0009615,GO:0016021,GO:0031902,GO:0032897,GO:0034341,GO:0035455,GO:0035456,GO:0045071,GO:0046597,GO:0051607,GO:0060337,GO:0070062 lysosomal membrane|plasma membrane|immune response|response to virus|integral component of membrane|late endosome membrane|negative regulation of viral transcription|response to interferon-gamma|response to interferon-alpha|response to interferon-beta|negative regulation of viral genome replication|negative regulation of viral entry into host cell|defense response to virus|type I interferon signaling pathway|extracellular exosome IFNAR1 774.070179848178 780.418548276724 767.721811419631 0.98373086225958 -0.0236644305358642 0.907226100204314 1 4.16602 3.76959 4.45727 3.40337 GeneID:3454,Genbank:XM_005260964.2,HGNC:HGNC:5432,MIM:107450 interferon alpha and beta receptor subunit 1 hsa04060,hsa04151,hsa04217,hsa04380,hsa04620,hsa04621,hsa04630,hsa04650,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05200 Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Pathways in cancer IFNAR2 396.594360171322 381.278240371952 411.910479970692 1.08034090686334 0.111486633716651 0.55511739368359 1 3.85998 4.08318 4.08995 4.50522 GeneID:3455,Genbank:NM_001289125.1,HGNC:HGNC:5433,MIM:602376 interferon alpha and beta receptor subunit 2 hsa04060,hsa04151,hsa04217,hsa04380,hsa04620,hsa04621,hsa04630,hsa04650,hsa05160,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05200 Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Pathways in cancer IFNB1 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0496358 0 0 0.0443413 GeneID:3456,Genbank:NM_002176.3,HGNC:HGNC:5434,MIM:147640 interferon beta 1 hsa04060,hsa04151,hsa04217,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04630,hsa04650,hsa04668,hsa05142,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170 Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|TNF signaling pathway|Chagas disease (American trypanosomiasis)|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection IFNE 2.58693118478635 3.71865746181119 1.45520490776151 0.391325343273953 -1.35355954884063 0.606125918281445 1 0.132862 0.0258143 0.0254636 0 GeneID:338376,Genbank:NM_176891.4,HGNC:HGNC:18163,MIM:615223 interferon epsilon GO:0002250,GO:0002286,GO:0002323,GO:0005125,GO:0005132,GO:0005615,GO:0006959,GO:0019221,GO:0030183,GO:0033141,GO:0042100,GO:0042742,GO:0043330,GO:0045087,GO:0051607 adaptive immune response|T cell activation involved in immune response|natural killer cell activation involved in immune response|cytokine activity|type I interferon receptor binding|extracellular space|humoral immune response|cytokine-mediated signaling pathway|B cell differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|B cell proliferation|defense response to bacterium|response to exogenous dsRNA|innate immune response|defense response to virus hsa04060,hsa04622,hsa04630 Cytokine-cytokine receptor interaction|RIG-I-like receptor signaling pathway|Jak-STAT signaling pathway IFNGR1 609.539114047561 644.739464522 574.338763573122 0.890807520211173 -0.1668143574559 0.318028724350309 1 6.37994 6.34879 6.31742 5.06828 GeneID:3459,Genbank:XM_011535793.2,HGNC:HGNC:5439,MIM:107470 interferon gamma receptor 1 hsa04060,hsa04066,hsa04217,hsa04380,hsa04630,hsa04650,hsa04658,hsa04659,hsa05132,hsa05140,hsa05142,hsa05145,hsa05152,hsa05162,hsa05164,hsa05167,hsa05168,hsa05200,hsa05321 Cytokine-cytokine receptor interaction|HIF-1 signaling pathway|Necroptosis|Osteoclast differentiation|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|Salmonella infection|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Measles|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Pathways in cancer|Inflammatory bowel disease (IBD) IFNGR2 971.783766119759 983.574615023256 959.992917216262 0.976024495298269 -0.0350107393103904 0.816863712266165 1 13.2791 13.6206 12.96 14.0588 GeneID:3460,Genbank:NM_001329128.1,HGNC:HGNC:5440,MIM:147569 interferon gamma receptor 2 hsa04060,hsa04066,hsa04217,hsa04380,hsa04630,hsa04650,hsa04658,hsa04659,hsa05132,hsa05140,hsa05142,hsa05145,hsa05152,hsa05162,hsa05164,hsa05168,hsa05200,hsa05321 Cytokine-cytokine receptor interaction|HIF-1 signaling pathway|Necroptosis|Osteoclast differentiation|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|Salmonella infection|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Measles|Influenza A|Herpes simplex infection|Pathways in cancer|Inflammatory bowel disease (IBD) IFNLR1 88.3460353330873 79.2846889117601 97.4073817544145 1.2285774604328 0.29698882087409 0.372031932057499 1 0.404433 0.560317 0.651099 0.644089 GeneID:163702,Genbank:XM_024453668.1,HGNC:HGNC:18584,MIM:607404 interferon lambda receptor 1 GO:0002385,GO:0004896,GO:0005886,GO:0008285,GO:0016021,GO:0019221,GO:0032002,GO:0034342,GO:0050691,GO:0051607 mucosal immune response|cytokine receptor activity|plasma membrane|negative regulation of cell proliferation|integral component of membrane|cytokine-mediated signaling pathway|interleukin-28 receptor complex|response to type III interferon|regulation of defense response to virus by host|defense response to virus hsa04060,hsa04630 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway IFRD1 3668.94234731832 3645.82194313123 3692.06275150541 1.01268323277863 0.0181829698286142 0.884964909916971 1 30.5335 31.4142 34.2975 28.9843 GeneID:3475,Genbank:NM_001007245.2,HGNC:HGNC:5456,MIM:603502 interferon related developmental regulator 1 GO:0005634,GO:0005737,GO:0007518,GO:0014706,GO:0030517,GO:0042692,GO:0043403,GO:0048671 nucleus|cytoplasm|myoblast fate determination|striated muscle tissue development|negative regulation of axon extension|muscle cell differentiation|skeletal muscle tissue regeneration|negative regulation of collateral sprouting IFRD2 2217.9277010367 2273.51724050645 2162.33816156695 0.951098202838023 -0.0723337848919981 0.581908515444578 1 50.3007 54.6588 50.2927 52.1145 GeneID:7866,Genbank:NM_006764.4,HGNC:HGNC:5457,MIM:602725 interferon related developmental regulator 2 GO:0005634 nucleus IFT122 640.752073391355 628.712204082316 652.791942700394 1.03830009734458 0.0542234825953035 0.765310626988819 1 1.87805 2.3253 2.33991 2.23743 GeneID:55764,Genbank:NM_001280545.1,HGNC:HGNC:13556,MIM:606045 intraflagellar transport 122 GO:0001843,GO:0005654,GO:0005829,GO:0005929,GO:0007227,GO:0010172,GO:0016020,GO:0021914,GO:0030991,GO:0032391,GO:0035050,GO:0035115,GO:0035720,GO:0035721,GO:0035735,GO:0036064,GO:0042733,GO:0045879,GO:0048593,GO:0050680,GO:0060173,GO:0060271,GO:0060830,GO:0060831,GO:0060971,GO:0061512,GO:0072594,GO:0097542,GO:0097546,GO:1905515 neural tube closure|nucleoplasm|cytosol|cilium|signal transduction downstream of smoothened|embryonic body morphogenesis|membrane|negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning|intraciliary transport particle A|photoreceptor connecting cilium|embryonic heart tube development|embryonic forelimb morphogenesis|intraciliary anterograde transport|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|embryonic digit morphogenesis|negative regulation of smoothened signaling pathway|camera-type eye morphogenesis|negative regulation of epithelial cell proliferation|limb development|cilium assembly|ciliary receptor clustering involved in smoothened signaling pathway|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|embryonic heart tube left/right pattern formation|protein localization to cilium|establishment of protein localization to organelle|ciliary tip|ciliary base|non-motile cilium assembly IFT140 355.059725499251 335.510511892033 374.60893910647 1.11653413478448 0.159027358040379 0.419457619015007 1 0.699749 0.836287 0.860633 0.864236 GeneID:9742,Genbank:NM_014714.3,HGNC:HGNC:29077,MIM:614620 intraflagellar transport 140 GO:0001750,GO:0005813,GO:0005929,GO:0005930,GO:0007368,GO:0007507,GO:0008589,GO:0021532,GO:0030991,GO:0031076,GO:0032391,GO:0035721,GO:0035735,GO:0035845,GO:0036064,GO:0042733,GO:0048701,GO:0048705,GO:0060041,GO:0061512,GO:0072001,GO:0097542,GO:1902017,GO:1905515,GO:1990403 photoreceptor outer segment|centrosome|cilium|axoneme|determination of left/right symmetry|heart development|regulation of smoothened signaling pathway|neural tube patterning|intraciliary transport particle A|embryonic camera-type eye development|photoreceptor connecting cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|photoreceptor cell outer segment organization|ciliary basal body|embryonic digit morphogenesis|embryonic cranial skeleton morphogenesis|skeletal system morphogenesis|retina development in camera-type eye|protein localization to cilium|renal system development|ciliary tip|regulation of cilium assembly|non-motile cilium assembly|embryonic brain development IFT172 475.867113541364 496.683117203648 455.051109879081 0.916179942739031 -0.126297115558701 0.473175339631076 1 1.56643 1.46497 1.39711 1.62993 GeneID:26160,Genbank:XM_017003790.1,HGNC:HGNC:30391,MIM:607386 intraflagellar transport 172 GO:0001843,GO:0001947,GO:0005929,GO:0005930,GO:0007219,GO:0007224,GO:0007420,GO:0008544,GO:0009953,GO:0016485,GO:0021522,GO:0030992,GO:0031122,GO:0035735,GO:0036064,GO:0045880,GO:0050680,GO:0060021,GO:0060173,GO:0060271,GO:0060348,GO:0061525,GO:0070986,GO:0097225,GO:0097228,GO:0097542,GO:0097598,GO:1903561,GO:1905515 neural tube closure|heart looping|cilium|axoneme|Notch signaling pathway|smoothened signaling pathway|brain development|epidermis development|dorsal/ventral pattern formation|protein processing|spinal cord motor neuron differentiation|intraciliary transport particle B|cytoplasmic microtubule organization|intraciliary transport involved in cilium assembly|ciliary basal body|positive regulation of smoothened signaling pathway|negative regulation of epithelial cell proliferation|palate development|limb development|cilium assembly|bone development|hindgut development|left/right axis specification|sperm midpiece|sperm principal piece|ciliary tip|sperm cytoplasmic droplet|extracellular vesicle|non-motile cilium assembly IFT20 389.208736942959 392.684152785919 385.733321099999 0.98229917954008 -0.025765600793425 0.893366377677444 1 8.0646 8.17228 7.19554 8.36055 GeneID:90410,Genbank:NM_001267778.1,HGNC:HGNC:30989,MIM:614394 intraflagellar transport 20 GO:0001736,GO:0001750,GO:0001822,GO:0002046,GO:0005794,GO:0005801,GO:0005813,GO:0005814,GO:0005902,GO:0005929,GO:0007224,GO:0008542,GO:0017137,GO:0030992,GO:0031514,GO:0032391,GO:0032420,GO:0034067,GO:0035845,GO:0036372,GO:0042073,GO:0044292,GO:0051642,GO:0055007,GO:0060122,GO:0060271,GO:0060828,GO:0061351,GO:0061512,GO:0072659,GO:0090102,GO:0097546,GO:1902017,GO:1902636,GO:2000785 establishment of planar polarity|photoreceptor outer segment|kidney development|opsin binding|Golgi apparatus|cis-Golgi network|centrosome|centriole|microvillus|cilium|smoothened signaling pathway|visual learning|Rab GTPase binding|intraciliary transport particle B|motile cilium|photoreceptor connecting cilium|stereocilium|protein localization to Golgi apparatus|photoreceptor cell outer segment organization|opsin transport|intraciliary transport|dendrite terminus|centrosome localization|cardiac muscle cell differentiation|inner ear receptor cell stereocilium organization|cilium assembly|regulation of canonical Wnt signaling pathway|neural precursor cell proliferation|protein localization to cilium|protein localization to plasma membrane|cochlea development|ciliary base|regulation of cilium assembly|kinociliary basal body|regulation of autophagosome assembly IFT22 773.614686198737 764.584409936635 782.644962460839 1.02362139783324 0.0336822109749853 0.853130015790981 1 8.17487 8.96111 8.42375 8.99472 GeneID:64792,Genbank:NM_001287526.1,HGNC:HGNC:21895 intraflagellar transport 22 GO:0005525,GO:0005813,GO:0005929,GO:0030992,GO:0035735,GO:0097542 GTP binding|centrosome|cilium|intraciliary transport particle B|intraciliary transport involved in cilium assembly|ciliary tip IFT27 97.235667567206 79.6110641794467 114.860270954965 1.44276768736649 0.528839017593435 0.0788267652173014 0.945231254824065 0.719672 0.711003 1.07538 1.14407 GeneID:11020,Genbank:NM_006860.4,HGNC:HGNC:18626,MIM:615870 intraflagellar transport 27 GO:0003924,GO:0005525,GO:0005768,GO:0005794,GO:0005813,GO:0005929,GO:0006886,GO:0007224,GO:0030992,GO:0031514,GO:0035735,GO:0042073,GO:0060122,GO:0090102,GO:0097225,GO:0097228,GO:0097542 GTPase activity|GTP binding|endosome|Golgi apparatus|centrosome|cilium|intracellular protein transport|smoothened signaling pathway|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|intraciliary transport|inner ear receptor cell stereocilium organization|cochlea development|sperm midpiece|sperm principal piece|ciliary tip IFT43 291.181112589879 276.107028051569 306.255197128189 1.10919015459103 0.149506715877211 0.468299845764019 1 4.35489 4.70128 4.90455 5.01288 GeneID:112752,Genbank:NM_001102564.1,HGNC:HGNC:29669,MIM:614068 intraflagellar transport 43 GO:0005737,GO:0005815,GO:0005929,GO:0015630,GO:0030991,GO:0035721,GO:0035735,GO:0060271,GO:0097542 cytoplasm|microtubule organizing center|cilium|microtubule cytoskeleton|intraciliary transport particle A|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|cilium assembly|ciliary tip IFT46 308.003846916079 307.816573353888 308.191120478271 1.00121678673861 0.00175438505371104 0.991037149901909 1 1.4389 1.3346 1.33228 1.66112 GeneID:56912,Genbank:NM_001168618.1,HGNC:HGNC:26146 intraflagellar transport 46 GO:0005737,GO:0005813,GO:0005929,GO:0007224,GO:0008022,GO:0030992,GO:0031514,GO:0035735,GO:0042073,GO:0050821,GO:0060271,GO:0097542 cytoplasm|centrosome|cilium|smoothened signaling pathway|protein C-terminus binding|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|intraciliary transport|protein stabilization|cilium assembly|ciliary tip IFT52 445.828736834529 445.831361259668 445.826112409391 0.999988226825807 -1.6985200008478e-05 0.990632035037836 1 5.70823 5.64493 5.45678 6.14453 GeneID:51098,Genbank:NM_001323578.1,HGNC:HGNC:15901,MIM:617094 intraflagellar transport 52 GO:0001841,GO:0001947,GO:0005813,GO:0005814,GO:0005929,GO:0007224,GO:0008022,GO:0009953,GO:0030992,GO:0031514,GO:0032391,GO:0035720,GO:0035735,GO:0042733,GO:0044292,GO:0050680,GO:0060271,GO:0070613,GO:0097542,GO:0097546,GO:1905515 neural tube formation|heart looping|centrosome|centriole|cilium|smoothened signaling pathway|protein C-terminus binding|dorsal/ventral pattern formation|intraciliary transport particle B|motile cilium|photoreceptor connecting cilium|intraciliary anterograde transport|intraciliary transport involved in cilium assembly|embryonic digit morphogenesis|dendrite terminus|negative regulation of epithelial cell proliferation|cilium assembly|regulation of protein processing|ciliary tip|ciliary base|non-motile cilium assembly IFT57 317.753428017738 322.412854208131 313.094001827346 0.971096523419724 -0.0423133935394182 0.841857181660062 1 3.37765 3.43918 3.78721 3.12058 GeneID:55081,Genbank:NM_018010.3,HGNC:HGNC:17367,MIM:606621 intraflagellar transport 57 GO:0001843,GO:0001947,GO:0003677,GO:0005794,GO:0005813,GO:0005929,GO:0005930,GO:0006351,GO:0006355,GO:0006915,GO:0006919,GO:0007224,GO:0030992,GO:0032391,GO:0035735,GO:0036064,GO:0042073,GO:0042981,GO:0044292,GO:0044458,GO:0050680,GO:0060271,GO:0060972,GO:0097542,GO:1905515 neural tube closure|heart looping|DNA binding|Golgi apparatus|centrosome|cilium|axoneme|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|smoothened signaling pathway|intraciliary transport particle B|photoreceptor connecting cilium|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|regulation of apoptotic process|dendrite terminus|motile cilium assembly|negative regulation of epithelial cell proliferation|cilium assembly|left/right pattern formation|ciliary tip|non-motile cilium assembly hsa05016 Huntington disease IFT74 78.3254828742553 73.7782336306433 82.8727321178673 1.12326804315693 0.167702236189375 0.606809111100676 1 0.22079 0.206857 0.238047 0.225915 GeneID:80173,Genbank:NM_001099223.2,HGNC:HGNC:21424,MIM:608040 intraflagellar transport 74 GO:0003334,GO:0003682,GO:0005634,GO:0005813,GO:0005929,GO:0007219,GO:0007368,GO:0007507,GO:0030992,GO:0031410,GO:0031514,GO:0033630,GO:0035735,GO:0045944,GO:0048487,GO:0050680,GO:0060271,GO:0097542,GO:1905515 keratinocyte development|chromatin binding|nucleus|centrosome|cilium|Notch signaling pathway|determination of left/right symmetry|heart development|intraciliary transport particle B|cytoplasmic vesicle|motile cilium|positive regulation of cell adhesion mediated by integrin|intraciliary transport involved in cilium assembly|positive regulation of transcription from RNA polymerase II promoter|beta-tubulin binding|negative regulation of epithelial cell proliferation|cilium assembly|ciliary tip|non-motile cilium assembly IFT80 137.410761687975 136.678843868855 138.142679507096 1.01071003819469 0.0153691629585261 0.951540784023227 1 1.12536 0.857686 1.14219 0.838076 GeneID:57560,Genbank:NM_020800.2,HGNC:HGNC:29262,MIM:611177 intraflagellar transport 80 GO:0001649,GO:0002062,GO:0005737,GO:0005813,GO:0005929,GO:0007224,GO:0030992,GO:0035735,GO:0045880,GO:0050680,GO:0060271,GO:0060349,GO:0097542,GO:1905515,GO:2000051 osteoblast differentiation|chondrocyte differentiation|cytoplasm|centrosome|cilium|smoothened signaling pathway|intraciliary transport particle B|intraciliary transport involved in cilium assembly|positive regulation of smoothened signaling pathway|negative regulation of epithelial cell proliferation|cilium assembly|bone morphogenesis|ciliary tip|non-motile cilium assembly|negative regulation of non-canonical Wnt signaling pathway IFT81 105.504976082936 115.049075598685 95.9608765671869 0.834086463257806 -0.26173115048887 0.389966824112334 1 1.03236 0.852362 0.827657 0.656609 GeneID:28981,Genbank:NM_014055.3,HGNC:HGNC:14313,MIM:605489 intraflagellar transport 81 GO:0005813,GO:0005929,GO:0007283,GO:0015631,GO:0030992,GO:0031514,GO:0035735,GO:0036064,GO:0060271,GO:0097225,GO:0097228,GO:0097542 centrosome|cilium|spermatogenesis|tubulin binding|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|ciliary basal body|cilium assembly|sperm midpiece|sperm principal piece|ciliary tip IFT88 50.2513267337307 53.0129383048023 47.4897151626592 0.895813676457871 -0.158729402786932 0.78101950079325 1 0.265371 0.194859 0.20275 0.24918 GeneID:8100,Genbank:XM_017020773.1,HGNC:HGNC:20606,MIM:600595 intraflagellar transport 88 GO:0005814,GO:0005929,GO:0030992,GO:0031514,GO:0035735,GO:0036064,GO:0060271,GO:0097542,GO:1902017,GO:2000785 centriole|cilium|intraciliary transport particle B|motile cilium|intraciliary transport involved in cilium assembly|ciliary basal body|cilium assembly|ciliary tip|regulation of cilium assembly|regulation of autophagosome assembly IGBP1 1259.69077240253 1291.39118837714 1227.99035642791 0.950905014282381 -0.0726268571324983 0.623893345498551 1 25.3577 25.2651 23.1854 24.7074 GeneID:3476,Genbank:XM_017029489.1,HGNC:HGNC:5461,MIM:300139 immunoglobulin binding protein 1 GO:0000122,GO:0005737,GO:0005829,GO:0007165,GO:0019888,GO:0032873,GO:0034612,GO:0035303,GO:0042113,GO:0043154,GO:0051721,GO:0060632,GO:0070555 negative regulation of transcription from RNA polymerase II promoter|cytoplasm|cytosol|signal transduction|protein phosphatase regulator activity|negative regulation of stress-activated MAPK cascade|response to tumor necrosis factor|regulation of dephosphorylation|B cell activation|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphatase 2A binding|regulation of microtubule-based movement|response to interleukin-1 hsa04136,hsa04140 Autophagy - other|Autophagy - animal IGDCC3 1.21974041949651 1.47021420587209 0.969266633120943 0.659268989001506 -0.60106087408571 0.974346500689373 1 0 0.0258791 0.00912938 0.00854344 GeneID:9543,Genbank:NM_004884.3,HGNC:HGNC:9700,MIM:604184 immunoglobulin superfamily DCC subclass member 3 GO:0005887,GO:0050885 integral component of plasma membrane|neuromuscular process controlling balance IGDCC4 35.6181926460193 37.3120531328056 33.924332159233 0.909205720695278 -0.137321333308875 0.790243905386234 1 0.206673 0.224865 0.192622 0.161149 GeneID:57722,Genbank:XM_011521846.3,HGNC:HGNC:13770,MIM:616810 immunoglobulin superfamily DCC subclass member 4 GO:0005886,GO:0016021 plasma membrane|integral component of membrane IGF1 1.93896825226858 0 3.87793650453717 Inf Inf 0.142672625244967 1 0 0 0.0154195 0.00861562 GeneID:3479,Genbank:XM_017019262.2,HGNC:HGNC:5464,MIM:147440 insulin like growth factor 1 GO:0005159,GO:0005179,GO:0005615,GO:0008083,GO:0008284,GO:0035867,GO:0043066,GO:0045725,GO:0046326,GO:0048009,GO:0070382,GO:0090201 insulin-like growth factor receptor binding|hormone activity|extracellular space|growth factor activity|positive regulation of cell proliferation|alphav-beta3 integrin-IGF-1-IGF1R complex|negative regulation of apoptotic process|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|insulin-like growth factor receptor signaling pathway|exocytic vesicle|negative regulation of release of cytochrome c from mitochondria hsa01521,hsa01522,hsa04010,hsa04014,hsa04015,hsa04066,hsa04068,hsa04114,hsa04115,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04510,hsa04550,hsa04730,hsa04750,hsa04913,hsa04914,hsa04960,hsa05200,hsa05202,hsa05205,hsa05214,hsa05215,hsa05218,hsa05224,hsa05410,hsa05414 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Oocyte meiosis|p53 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Long-term depression|Inflammatory mediator regulation of TRP channels|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Aldosterone-regulated sodium reabsorption|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|Glioma|Prostate cancer|Melanoma|Breast cancer|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) IGF1R 4921.82615161173 4763.84555907676 5079.8067441467 1.06632481703105 0.0926469695603749 0.478412595003181 1 14.2131 13.4683 16.7492 13.3818 GeneID:3480,Genbank:NM_000875.4,HGNC:HGNC:5465,MIM:147370 insulin like growth factor 1 receptor hsa01521,hsa01522,hsa04010,hsa04014,hsa04015,hsa04066,hsa04068,hsa04114,hsa04140,hsa04144,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04510,hsa04520,hsa04550,hsa04730,hsa04913,hsa04914,hsa05200,hsa05202,hsa05205,hsa05214,hsa05215,hsa05218,hsa05224,hsa05225 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Oocyte meiosis|Autophagy - animal|Endocytosis|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Focal adhesion|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Long-term depression|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|Glioma|Prostate cancer|Melanoma|Breast cancer|Hepatocellular carcinoma IGF2 2.77219446823291 2.15239070656922 3.3919982298966 1.57592123936608 0.656195434276946 0.79065450729908 1 0.0233942 0 0.0161918 0.0202333 GeneID:3481,Genbank:NM_001007139.5,HGNC:HGNC:5466,MIM:147470 insulin like growth factor 2 hsa04010,hsa04014,hsa04151,hsa05200,hsa05205,hsa05225 MAPK signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Pathways in cancer|Proteoglycans in cancer|Hepatocellular carcinoma IGF2BP1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00448833 0 GeneID:10642,Genbank:NM_006546.3,HGNC:HGNC:28866,MIM:608288 insulin like growth factor 2 mRNA binding protein 1 hsa05206 MicroRNAs in cancer IGF2BP2 2384.40623563735 2483.11558571331 2285.69688556138 0.920495565616122 -0.119517323316569 0.396580837529689 1 8.99111 8.8405 9.24491 7.35526 GeneID:10644,Genbank:NM_001007225.2,HGNC:HGNC:28867,MIM:608289 insulin like growth factor 2 mRNA binding protein 2 GO:0003730,GO:0005634,GO:0005737,GO:0005856,GO:0006417,GO:0048027,GO:0051028 mRNA 3'-UTR binding|nucleus|cytoplasm|cytoskeleton|regulation of translation|mRNA 5'-UTR binding|mRNA transport IGF2BP3 453.844752568284 435.049790416606 472.639714719962 1.08640372925444 0.119560336985092 0.784983426958695 1 2.79417 2.59341 3.98621 2.09506 GeneID:10643,Genbank:XM_011515089.2,HGNC:HGNC:28868,MIM:608259 insulin like growth factor 2 mRNA binding protein 3 GO:0003723,GO:0003730,GO:0005634,GO:0005737,GO:0005829,GO:0006412,GO:0009653,GO:0017148,GO:0042035,GO:0043488,GO:0045182,GO:0048027,GO:0051028 RNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|cytosol|translation|anatomical structure morphogenesis|negative regulation of translation|regulation of cytokine biosynthetic process|regulation of mRNA stability|translation regulator activity|mRNA 5'-UTR binding|mRNA transport IGF2R 14275.8128039567 12488.0794314444 16063.546176469 1.2863103782013 0.363238797459137 0.00517093935617129 0.285578499063584 31.0944 32.3036 45.3582 37.6831 GeneID:3482,Genbank:NM_000876.3,HGNC:HGNC:5467,MIM:147280 insulin like growth factor 2 receptor hsa04142,hsa04144 Lysosome|Endocytosis IGFALS 1.27320477957835 2.54640955915669 0 0 -Inf 0.30183743838593 1 0.0716608 0.0886216 0 0 GeneID:3483,Genbank:NM_004970.2,HGNC:HGNC:5468,MIM:601489 insulin like growth factor binding protein acid labile subunit GO:0005520,GO:0005576,GO:0005615,GO:0005654,GO:0007155,GO:0007165,GO:0042567,GO:0044267,GO:0070062 insulin-like growth factor binding|extracellular region|extracellular space|nucleoplasm|cell adhesion|signal transduction|insulin-like growth factor ternary complex|cellular protein metabolic process|extracellular exosome IGFBP2 5046.06705853385 4787.80935884971 5304.32475821798 1.10788136298985 0.147803399266143 0.419552603524316 1 100.147 108.603 112.474 124.868 GeneID:3485,Genbank:NM_001313992.1,HGNC:HGNC:5471,MIM:146731 insulin like growth factor binding protein 2 IGFBP3 56.9498787285017 38.7724586835697 75.1272987734338 1.93764598181827 0.954305006805727 0.0119354107241315 0.445971779139093 0.70366 0.543487 1.51136 0.939696 GeneID:3486,Genbank:NM_000598.4,HGNC:HGNC:5472,MIM:146732 insulin like growth factor binding protein 3 hsa04115,hsa04218,hsa05202 p53 signaling pathway|Cellular senescence|Transcriptional misregulation in cancer IGFBP4 821.497141356675 619.900727502192 1023.09355521116 1.65041515491291 0.722828973923877 5.67158814039138e-06 0.00313228122953477 13.6206 14.5176 25.0151 21.9837 GeneID:3487,Genbank:NM_001552.2,HGNC:HGNC:5473,MIM:146733 insulin like growth factor binding protein 4 IGFBP5 12733.1393155018 12291.6511111571 13174.6275198465 1.07183545975267 0.100083450927737 0.445508402513992 1 74.4624 76.1077 83.2581 79.742 GeneID:3488,Genbank:NM_000599.3,HGNC:HGNC:5474,MIM:146734 insulin like growth factor binding protein 5 IGFBP6 577.309189477272 572.633358851076 581.985020103469 1.01633097532277 0.0233703024037198 0.906784933932774 1 28.6574 29.2374 26.8675 31.9703 GeneID:3489,Genbank:NM_002178.2,HGNC:HGNC:5475,MIM:146735 insulin like growth factor binding protein 6 IGFBP7 8153.75346793736 7579.94420878575 8727.56272708897 1.15140197430121 0.203391591148683 0.3976283658188 1 214.547 244.813 235.063 288.685 GeneID:3490,Genbank:NM_001553.2,HGNC:HGNC:5476,MIM:602867 insulin like growth factor binding protein 7 IGFL1 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.129559 0 0 0 GeneID:374918,Genbank:NM_198541.1,HGNC:HGNC:24093,MIM:610544 IGF like family member 1 GO:0005615 extracellular space IGFL2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0103426 0 0 GeneID:147920,Genbank:XM_024451381.1,HGNC:HGNC:32929,MIM:610545 IGF like family member 2 GO:0005102,GO:0005615 receptor binding|extracellular space IGFL4 1.23875045746879 0.538097676642304 1.93940323829528 3.60418437484629 1.84967281522267 0.680545261345893 1 0 0 0.102844 0 GeneID:444882,Genbank:NM_001002923.1,HGNC:HGNC:32931,MIM:610547 IGF like family member 4 GO:0005576 extracellular region IGFLR1 165.433878475857 156.887441208692 173.980315743022 1.10894992233058 0.149194218126708 0.563572336618661 1 3.64965 4.03588 4.34652 4.2426 GeneID:79713,Genbank:NM_001346005.1,HGNC:HGNC:23620,MIM:614143 IGF like family receptor 1 GO:0005886,GO:0016021 plasma membrane|integral component of membrane IGHMBP2 551.472812323181 545.160951376995 557.784673269367 1.02315595396275 0.0330260638129557 0.85930209345958 1 2.51074 2.48749 2.53194 2.64193 GeneID:3508,Genbank:NM_002180.2,HGNC:HGNC:5542,MIM:600502 immunoglobulin mu binding protein 2 GO:0000049,GO:0003677,GO:0003678,GO:0003697,GO:0003723,GO:0005524,GO:0005634,GO:0005737,GO:0006260,GO:0006281,GO:0006310,GO:0006351,GO:0006355,GO:0006412,GO:0008094,GO:0008134,GO:0008186,GO:0008270,GO:0016020,GO:0030424,GO:0030426,GO:0030529,GO:0032575,GO:0043022,GO:0043141,GO:0051260 tRNA binding|DNA binding|DNA helicase activity|single-stranded DNA binding|RNA binding|ATP binding|nucleus|cytoplasm|DNA replication|DNA repair|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|translation|DNA-dependent ATPase activity|transcription factor binding|RNA-dependent ATPase activity|zinc ion binding|membrane|axon|growth cone|intracellular ribonucleoprotein complex|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|ATP-dependent 5'-3' DNA helicase activity|protein homooligomerization IGIP 23.1502500172153 24.9740241896096 21.3264758448209 0.853946311691882 -0.227782725616166 0.714762714192117 1 0.371825 0.528384 0.450264 0.318968 GeneID:492311,Genbank:NM_001007189.1,HGNC:HGNC:33847 IgA inducing protein GO:0005576 extracellular region IGSF1 277.554529418044 267.737596598717 287.371462237372 1.07333249378526 0.102097059160053 0.634187497081979 1 1.40501 1.48613 1.57799 1.67312 GeneID:3547,Genbank:XM_011531330.1,HGNC:HGNC:5948,MIM:300137 immunoglobulin superfamily member 1 GO:0004872,GO:0005576,GO:0006355,GO:0007165,GO:0015026,GO:0016020,GO:0016021,GO:0034711 receptor activity|extracellular region|regulation of transcription, DNA-templated|signal transduction|coreceptor activity|membrane|integral component of membrane|inhibin binding IGSF10 7.22933055471863 11.549991238021 2.90866987141623 0.251833080343929 -1.98946028953705 0.147458439965569 1 0.0448137 0.0182112 0.0122652 0.0057114 GeneID:285313,Genbank:XM_011512709.2,HGNC:HGNC:26384,MIM:617351 immunoglobulin superfamily member 10 GO:0001503,GO:0005576,GO:2001222 ossification|extracellular region|regulation of neuron migration IGSF11 41.7674586001237 26.3481858461118 57.1867313541356 2.17042386478288 1.11797681589802 0.0134409962754487 0.476263266255721 0.174731 0.253093 0.444863 0.465965 GeneID:152404,Genbank:NM_001353320.1,HGNC:HGNC:16669,MIM:608351 immunoglobulin superfamily member 11 GO:0005886,GO:0007155,GO:0016021,GO:0040008,GO:0070062 plasma membrane|cell adhesion|integral component of membrane|regulation of growth|extracellular exosome IGSF22 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00415503 GeneID:283284,Genbank:NM_173588.3,HGNC:HGNC:26750 immunoglobulin superfamily member 22 GO:0005859,GO:0006941,GO:0007015,GO:0008307,GO:0030018,GO:0031430,GO:0045214,GO:0051015,GO:0051371,GO:0071688,GO:0097493 muscle myosin complex|striated muscle contraction|actin filament organization|structural constituent of muscle|Z disc|M band|sarcomere organization|actin filament binding|muscle alpha-actinin binding|striated muscle myosin thick filament assembly|structural molecule activity conferring elasticity IGSF23 1.02523254288787 1.56626675524197 0.484198330533773 0.309141676482158 -1.69365993276169 0.789571303159055 1 0.0210817 0 0 0 GeneID:147710,Genbank:XM_017026318.1,HGNC:HGNC:40040 immunoglobulin superfamily member 23 GO:0016021 integral component of membrane IGSF3 5569.94690389631 5473.0011846684 5666.89262312421 1.03542689502772 0.0502256975428636 0.721699749186196 1 22.7022 24.3382 25.7508 23.2687 GeneID:3321,Genbank:NM_001007237.2,HGNC:HGNC:5950,MIM:603491 immunoglobulin superfamily member 3 GO:0005886,GO:0007166,GO:0009986,GO:0016021,GO:0032808 plasma membrane|cell surface receptor signaling pathway|cell surface|integral component of membrane|lacrimal gland development IGSF5 1.74989846105683 1.07619535328461 2.42360156882906 2.25200895119282 1.17121256179462 0.729411591636508 1 0.0108485 0 0.0309405 0.0192075 GeneID:150084,Genbank:XM_011529472.2,HGNC:HGNC:5952,MIM:610638 immunoglobulin superfamily member 5 GO:0005923,GO:0016021,GO:0016324 bicellular tight junction|integral component of membrane|apical plasma membrane hsa04530,hsa05120 Tight junction|Epithelial cell signaling in Helicobacter pylori infection IGSF6 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0404796 0 0 0 GeneID:10261,Genbank:NM_005849.3,HGNC:HGNC:5953,MIM:606222 immunoglobulin superfamily member 6 GO:0004888,GO:0005887,GO:0006955,GO:0007166 transmembrane signaling receptor activity|integral component of plasma membrane|immune response|cell surface receptor signaling pathway IGSF8 737.384932294427 782.255389371569 692.514475217285 0.885279263813857 -0.175795465718977 0.266970724526434 1 5.39076 5.48022 4.8657 4.87355 GeneID:93185,Genbank:NM_001206665.2,HGNC:HGNC:17813,MIM:606644 immunoglobulin superfamily member 8 IGSF9 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0109142 0 0 GeneID:57549,Genbank:NM_020789.3,HGNC:HGNC:18132,MIM:609738 immunoglobulin superfamily member 9 GO:0005886,GO:0007156,GO:0007399,GO:0016021,GO:0016358,GO:0030054,GO:0030154,GO:0030424,GO:0030425,GO:0050807,GO:0060077,GO:0098632 plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|nervous system development|integral component of membrane|dendrite development|cell junction|cell differentiation|axon|dendrite|regulation of synapse organization|inhibitory synapse|cell-cell adhesion mediator activity IGSF9B 11.0927167681519 13.9523219731229 8.23311156318093 0.590088988703157 -0.760995557565807 0.44403076538424 1 0.0728368 0.0240814 0.00516708 0.0387296 GeneID:22997,Genbank:XM_011542695.2,HGNC:HGNC:32326,MIM:613773 immunoglobulin superfamily member 9B GO:0007156,GO:0007399,GO:0014069,GO:0016021,GO:0019900,GO:0030054,GO:0030425,GO:0043025,GO:0045211,GO:0060077,GO:0097151 homophilic cell adhesion via plasma membrane adhesion molecules|nervous system development|postsynaptic density|integral component of membrane|kinase binding|cell junction|dendrite|neuronal cell body|postsynaptic membrane|inhibitory synapse|positive regulation of inhibitory postsynaptic potential IHH 2.07197667343312 2.69048838321152 1.45346496365472 0.540223467502869 -0.888371782484703 0.831338985324982 1 0.138988 0 0.0256598 0.0478907 GeneID:3549,Genbank:NM_002181.3,HGNC:HGNC:5956,MIM:600726 indian hedgehog GO:0001501,GO:0001569,GO:0001649,GO:0001701,GO:0001708,GO:0001947,GO:0002053,GO:0003382,GO:0003406,GO:0003413,GO:0005113,GO:0005509,GO:0005578,GO:0005615,GO:0005886,GO:0006029,GO:0007224,GO:0007267,GO:0008233,GO:0009612,GO:0009880,GO:0016539,GO:0030704,GO:0031016,GO:0032355,GO:0032967,GO:0033085,GO:0033088,GO:0033089,GO:0035264,GO:0035988,GO:0040008,GO:0042733,GO:0043066,GO:0045453,GO:0045880,GO:0045944,GO:0046638,GO:0046639,GO:0048074,GO:0048469,GO:0048557,GO:0048596,GO:0048666,GO:0048745,GO:0050679,GO:0051216,GO:0060135,GO:0060220,GO:0060323,GO:0061053,GO:0072498,GO:0090136,GO:0097421 skeletal system development|branching involved in blood vessel morphogenesis|osteoblast differentiation|in utero embryonic development|cell fate specification|heart looping|positive regulation of mesenchymal cell proliferation|epithelial cell morphogenesis|retinal pigment epithelium development|chondrocyte differentiation involved in endochondral bone morphogenesis|patched binding|calcium ion binding|proteinaceous extracellular matrix|extracellular space|plasma membrane|proteoglycan metabolic process|smoothened signaling pathway|cell-cell signaling|peptidase activity|response to mechanical stimulus|embryonic pattern specification|intein-mediated protein splicing|vitelline membrane formation|pancreas development|response to estradiol|positive regulation of collagen biosynthetic process|negative regulation of T cell differentiation in thymus|negative regulation of immature T cell proliferation in thymus|positive regulation of T cell differentiation in thymus|multicellular organism growth|chondrocyte proliferation|regulation of growth|embryonic digit morphogenesis|negative regulation of apoptotic process|bone resorption|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of alpha-beta T cell differentiation|negative regulation of alpha-beta T cell differentiation|negative regulation of eye pigmentation|cell maturation|embryonic digestive tract morphogenesis|embryonic camera-type eye morphogenesis|neuron development|smooth muscle tissue development|positive regulation of epithelial cell proliferation|cartilage development|maternal process involved in female pregnancy|camera-type eye photoreceptor cell fate commitment|head morphogenesis|somite development|embryonic skeletal joint development|epithelial cell-cell adhesion|liver regeneration hsa04340,hsa05205 Hedgehog signaling pathway|Proteoglycans in cancer IK 2141.45664710136 2201.42668414233 2081.4866100604 0.945517116265602 -0.0808245200248666 0.568298096090291 1 27.6822 27.2747 26.9197 25.3604 GeneID:3550,Genbank:NM_006083.3,HGNC:HGNC:5958,MIM:600549 IK cytokine GO:0000278,GO:0000922,GO:0005654,GO:0005681,GO:0005694,GO:0005737,GO:0006397,GO:0007094,GO:0008380,GO:0016032,GO:0016607,GO:0034501,GO:0042802 mitotic cell cycle|spindle pole|nucleoplasm|spliceosomal complex|chromosome|cytoplasm|mRNA processing|mitotic spindle assembly checkpoint|RNA splicing|viral process|nuclear speck|protein localization to kinetochore|identical protein binding IKBIP 703.419265337029 723.974093157365 682.864437516692 0.94321667580481 -0.084338869902775 0.698396720054908 1 7.20292 5.93576 6.66745 5.88418 GeneID:121457,Genbank:NM_201613.2,HGNC:HGNC:26430,MIM:609861 IKBKB interacting protein GO:0005783,GO:0005789,GO:0016020,GO:0016021 endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane IKBKB 903.948855907591 929.725612738594 878.172099076589 0.944549754297777 -0.0823013020978422 0.588504363567624 1 4.75995 5.10052 5.15134 4.58199 GeneID:3551,Genbank:XM_005273491.5,HGNC:HGNC:5960,MIM:603258 inhibitor of nuclear factor kappa B kinase subunit beta hsa01523,hsa04010,hsa04014,hsa04062,hsa04064,hsa04068,hsa04150,hsa04151,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04910,hsa04920,hsa04930,hsa04931,hsa04932,hsa05120,hsa05131,hsa05142,hsa05145,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05206,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05418 Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|FoxO signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Fluid shear stress and atherosclerosis IKBKE 324.248639756628 301.033025966493 347.464253546763 1.15423964673377 0.206942791800028 0.298068441067013 1 2.65552 2.77023 3.0871 3.34897 GeneID:9641,Genbank:NM_014002.3,HGNC:HGNC:14552,MIM:605048 inhibitor of nuclear factor kappa B kinase subunit epsilon hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169 Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection IKBKG 378.268545059271 369.814493028193 386.722597090348 1.04572050144305 0.0644973018097543 0.736631684025981 1 3.97112 3.30763 3.83445 3.7398 GeneID:8517,Genbank:NM_001099856.4,HGNC:HGNC:5961,MIM:300248 inhibitor of nuclear factor kappa B kinase subunit gamma hsa01523,hsa04010,hsa04014,hsa04062,hsa04064,hsa04151,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04920,hsa05120,hsa05131,hsa05142,hsa05145,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05340,hsa05418 Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Primary immunodeficiency|Fluid shear stress and atherosclerosis IKZF1 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0 0 0.00464447 0.00216445 GeneID:10320,Genbank:XM_011515078.2,HGNC:HGNC:13176,MIM:603023 IKAROS family zinc finger 1 IKZF2 13.3863677241981 16.1047126796921 10.6680227687042 0.662416212004603 -0.594190113033775 0.558556128330945 1 0.0418312 0.0273458 0.0293351 0.00841373 GeneID:22807,Genbank:NM_001079526.1,HGNC:HGNC:13177,MIM:606234 IKAROS family zinc finger 2 IKZF3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:22806,Genbank:NM_001257409.1,HGNC:HGNC:13178,MIM:606221 IKAROS family zinc finger 3 GO:0000977,GO:0001228,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006357,GO:0007498,GO:0030888,GO:0042113,GO:0042802,GO:0042803,GO:0042981,GO:0043565,GO:0044212,GO:0045577,GO:0045619,GO:0045944,GO:0046872,GO:0046982 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|regulation of transcription from RNA polymerase II promoter|mesoderm development|regulation of B cell proliferation|B cell activation|identical protein binding|protein homodimerization activity|regulation of apoptotic process|sequence-specific DNA binding|transcription regulatory region DNA binding|regulation of B cell differentiation|regulation of lymphocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|protein heterodimerization activity IKZF4 179.327778616439 162.374279179593 196.281278053285 1.20882001167308 0.273599449221058 0.262620869204503 1 0.713911 0.878591 0.980775 0.879022 GeneID:64375,Genbank:XM_017019812.1,HGNC:HGNC:13179,MIM:606239 IKAROS family zinc finger 4 GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0008270,GO:0016604,GO:0019904,GO:0042803,GO:0043234,GO:0043425,GO:0043565,GO:0044212,GO:0045892,GO:0045944,GO:0046982,GO:0051260,GO:0051291 DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|zinc ion binding|nuclear body|protein domain specific binding|protein homodimerization activity|protein complex|bHLH transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|protein homooligomerization|protein heterooligomerization IKZF5 216.335523772938 231.539956438773 201.131091107103 0.868666878065554 -0.203125065720609 0.366148606550702 1 1.56503 1.6333 1.52362 1.32281 GeneID:64376,Genbank:NM_001271840.1,HGNC:HGNC:14283,MIM:606238 IKAROS family zinc finger 5 GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0006351,GO:0008270,GO:0019904,GO:0043234,GO:0051291 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|transcription, DNA-templated|zinc ion binding|protein domain specific binding|protein complex|protein heterooligomerization IL10RB 763.006243137158 719.133248069294 806.879238205022 1.12201631668582 0.166093656187845 0.305623053756444 1 13.0224 14.3153 15.0537 15.4841 GeneID:3588,Genbank:NM_000628.4,HGNC:HGNC:5965,MIM:123889 interleukin 10 receptor subunit beta hsa04060,hsa04630,hsa05145,hsa05152,hsa05163 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|Toxoplasmosis|Tuberculosis|Human cytomegalovirus infection IL11 621.809410210037 878.220089258386 365.398731161688 0.416067379499653 -1.26511091219777 7.69129118939341e-14 3.07959299223312e-10 17.4974 15.9553 7.09516 7.0446 GeneID:3589,Genbank:NM_001267718.1,HGNC:HGNC:5966,MIM:147681 interleukin 11 hsa04060,hsa04630,hsa04640,hsa05323 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|Hematopoietic cell lineage|Rheumatoid arthritis IL11RA 1.45640149936651 0.490071401957362 2.42273159677566 4.94362982026534 2.30557071806793 0.554025919298353 1 0 0 0.0529163 0.0741492 GeneID:3590,Genbank:NM_001142784.2,HGNC:HGNC:5967,MIM:600939 interleukin 11 receptor subunit alpha hsa04060,hsa04630,hsa04640 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|Hematopoietic cell lineage IL12A 16.3612504580519 23.9938813856949 8.72861953040887 0.36378522466202 -1.45884114656457 0.0409504282410313 0.759435523043776 0.546114 0.542993 0.368084 0.0570539 GeneID:3592,Genbank:NM_000882.3,HGNC:HGNC:5969,MIM:161560 interleukin 12A hsa04060,hsa04620,hsa04622,hsa04625,hsa04630,hsa04658,hsa04940,hsa05133,hsa05134,hsa05140,hsa05142,hsa05143,hsa05144,hsa05145,hsa05146,hsa05152,hsa05162,hsa05164,hsa05168,hsa05200,hsa05321,hsa05330 Cytokine-cytokine receptor interaction|Toll-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Type I diabetes mellitus|Pertussis|Legionellosis|Leishmaniasis|Chagas disease (American trypanosomiasis)|African trypanosomiasis|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Measles|Influenza A|Herpes simplex infection|Pathways in cancer|Inflammatory bowel disease (IBD)|Allograft rejection IL13 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0318816 0 0 0 GeneID:3596,Genbank:NM_001354992.1,HGNC:HGNC:5973,MIM:147683 interleukin 13 hsa04060,hsa04630,hsa04657,hsa04658,hsa04664,hsa05162,hsa05200,hsa05310,hsa05321 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Fc epsilon RI signaling pathway|Measles|Pathways in cancer|Asthma|Inflammatory bowel disease (IBD) IL13RA1 1343.89773613437 1339.98367540922 1347.81179685953 1.0058419528491 0.00840363342007278 0.950465976237035 1 11.5769 11.6332 12.7454 10.8207 GeneID:3597,Genbank:XM_011531336.1,HGNC:HGNC:5974,MIM:300119 interleukin 13 receptor subunit alpha 1 GO:0004896,GO:0005886,GO:0005898,GO:0007166,GO:0019221 cytokine receptor activity|plasma membrane|interleukin-13 receptor complex|cell surface receptor signaling pathway|cytokine-mediated signaling pathway hsa04060,hsa04630,hsa05200 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|Pathways in cancer IL13RA2 1789.94298001069 1744.06189795229 1835.82406206909 1.05261405241669 0.0739765600768406 0.576414604069939 1 43.4685 39.1206 47.1112 41.0464 GeneID:3598,Genbank:NM_000640.2,HGNC:HGNC:5975,MIM:300130 interleukin 13 receptor subunit alpha 2 hsa04060,hsa04630 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway IL15 73.9877559238428 57.3373370281566 90.638174819529 1.58078800860632 0.660643908215761 0.0529824316203929 0.840383088256616 0.76053 0.907336 1.512 1.09527 GeneID:3600,Genbank:NM_172175.2,HGNC:HGNC:5977,MIM:600554 interleukin 15 hsa04060,hsa04630,hsa04668,hsa04672,hsa05166,hsa05168,hsa05200,hsa05323 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|TNF signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Herpes simplex infection|Pathways in cancer|Rheumatoid arthritis IL15RA 19.1785217590631 20.9093741498959 17.4476693682304 0.83444244878641 -0.261115544057563 0.707380363637922 1 0.127087 0.13527 0.200576 0.132565 GeneID:3601,Genbank:XM_011519471.2,HGNC:HGNC:5978,MIM:601070 interleukin 15 receptor subunit alpha hsa04060,hsa04630,hsa04672,hsa05166,hsa05200 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Pathways in cancer IL16 1.75783809613882 2.54640955915669 0.969266633120943 0.380640509942925 -1.39349898523626 0.672311225248235 1 0.00860852 0.0117728 0.00406245 0.00379551 GeneID:3603,Genbank:NM_001352685.1,HGNC:HGNC:5980,MIM:603035 interleukin 16 hsa04060 Cytokine-cytokine receptor interaction IL17B 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:27190,Genbank:NM_001317987.1,HGNC:HGNC:5982,MIM:604627 interleukin 17B hsa04060,hsa04657 Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL17C 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:27189,Genbank:NM_013278.3,HGNC:HGNC:5983,MIM:604628 interleukin 17C hsa04060,hsa04657 Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL17D 65.3704389948446 64.8324868815719 65.9083911081173 1.01659514046578 0.023745239535943 0.987159890631247 1 0.678275 0.842476 0.679839 0.763496 GeneID:53342,Genbank:XM_005266421.4,HGNC:HGNC:5984,MIM:607587 interleukin 17D hsa04060,hsa04625,hsa04630,hsa04657,hsa04659 Cytokine-cytokine receptor interaction|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|IL-17 signaling pathway|Th17 cell differentiation IL17RA 1038.22872498609 1056.78634201279 1019.67110795939 0.964879150517119 -0.0515798363073141 0.726440698726033 1 4.87275 5.07698 4.98884 4.66219 GeneID:23765,Genbank:NM_014339.6,HGNC:HGNC:5985,MIM:605461 interleukin 17 receptor A GO:0005102,GO:0005576,GO:0005886,GO:0005887,GO:0007166,GO:0030368,GO:0032747,GO:0050832,GO:0071621,GO:0072537,GO:0097400,GO:1900017,GO:2000664,GO:2000667 receptor binding|extracellular region|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|interleukin-17 receptor activity|positive regulation of interleukin-23 production|defense response to fungus|granulocyte chemotaxis|fibroblast activation|interleukin-17-mediated signaling pathway|positive regulation of cytokine production involved in inflammatory response|positive regulation of interleukin-5 secretion|positive regulation of interleukin-13 secretion hsa04060,hsa04657 Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL17RB 204.552080013944 205.095718043291 204.008441984597 0.994698689621279 -0.00766851880011312 0.996566269561997 1 1.61078 1.68083 1.55739 1.94624 GeneID:55540,Genbank:XM_005265310.5,HGNC:HGNC:18015,MIM:605458 interleukin 17 receptor B hsa04060,hsa04657 Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL17RC 752.681991156004 636.899339091537 868.464643220472 1.36358226475668 0.447401740499872 0.00578770698901099 0.302955146691121 7.97567 9.07265 12.1836 11.5793 GeneID:84818,Genbank:NM_153460.3,HGNC:HGNC:18358,MIM:610925 interleukin 17 receptor C GO:0005102,GO:0005886,GO:0005887,GO:0009986,GO:0030368,GO:0050832,GO:0071621,GO:0097400,GO:1900017,GO:2000778 receptor binding|plasma membrane|integral component of plasma membrane|cell surface|interleukin-17 receptor activity|defense response to fungus|granulocyte chemotaxis|interleukin-17-mediated signaling pathway|positive regulation of cytokine production involved in inflammatory response|positive regulation of interleukin-6 secretion hsa04060,hsa04657 Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL17RD 572.481895947466 574.468165944212 570.495625950721 0.993084838762194 -0.010011123122426 0.973483576390638 1 2.53431 2.59151 3.10326 2.09385 GeneID:54756,Genbank:NM_001318864.1,HGNC:HGNC:17616,MIM:606807 interleukin 17 receptor D GO:0000139,GO:0000165,GO:0005654,GO:0005794,GO:0005887,GO:0030368 Golgi membrane|MAPK cascade|nucleoplasm|Golgi apparatus|integral component of plasma membrane|interleukin-17 receptor activity IL17RE 6.41033912509178 7.0050784514579 5.81559979872566 0.830197668595034 -0.268473214392608 0.855962206271429 1 0.0355195 0.0932705 0.0164686 0.0616054 GeneID:132014,Genbank:XM_011533361.3,HGNC:HGNC:18439,MIM:614995 interleukin 17 receptor E GO:0005576,GO:0005737,GO:0005886,GO:0005887,GO:0006954,GO:0030368,GO:0097400 extracellular region|cytoplasm|plasma membrane|integral component of plasma membrane|inflammatory response|interleukin-17 receptor activity|interleukin-17-mediated signaling pathway hsa04060,hsa04657 Cytokine-cytokine receptor interaction|IL-17 signaling pathway IL18 1272.48001388474 1395.45677937892 1149.50324839055 0.823746937473885 -0.27972689840789 0.0593189806312273 0.879410748501007 37.1658 37.8063 29.9543 32.2915 GeneID:3606,Genbank:NM_001243211.1,HGNC:HGNC:5986,MIM:600953 interleukin 18 hsa04060,hsa04621,hsa04623,hsa05132,hsa05134,hsa05143,hsa05144,hsa05152,hsa05164,hsa05321,hsa05323 Cytokine-cytokine receptor interaction|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Salmonella infection|Legionellosis|African trypanosomiasis|Malaria|Tuberculosis|Influenza A|Inflammatory bowel disease (IBD)|Rheumatoid arthritis IL18BP 67.3123470943609 71.6258429240741 62.9988512646477 0.879554762537715 -0.185154689808629 0.627800364322419 1 0.66257 0.508679 0.597502 0.46469 GeneID:10068,Genbank:XM_024448304.1,HGNC:HGNC:5987,MIM:604113 interleukin 18 binding protein GO:0005576,GO:0005615,GO:0032496,GO:0035655,GO:0042007,GO:0042088,GO:0048019,GO:0070062,GO:0070301,GO:0071345,GO:0071356 extracellular region|extracellular space|response to lipopolysaccharide|interleukin-18-mediated signaling pathway|interleukin-18 binding|T-helper 1 type immune response|receptor antagonist activity|extracellular exosome|cellular response to hydrogen peroxide|cellular response to cytokine stimulus|cellular response to tumor necrosis factor IL18R1 7.45838821371712 8.12930007942745 6.78747634800679 0.834939820364564 -0.260255878127507 0.856774645925176 1 0.0523515 0.0801721 0.090705 0.0281325 GeneID:8809,Genbank:XM_024453203.1,HGNC:HGNC:5988,MIM:604494 interleukin 18 receptor 1 GO:0004872,GO:0004908,GO:0005886,GO:0006955,GO:0007165,GO:0016021,GO:0030101,GO:0032729,GO:0035655,GO:0042008,GO:0042346,GO:0045063,GO:0071345 receptor activity|interleukin-1 receptor activity|plasma membrane|immune response|signal transduction|integral component of membrane|natural killer cell activation|positive regulation of interferon-gamma production|interleukin-18-mediated signaling pathway|interleukin-18 receptor activity|positive regulation of NF-kappaB import into nucleus|T-helper 1 cell differentiation|cellular response to cytokine stimulus hsa04060,hsa04668,hsa05321 Cytokine-cytokine receptor interaction|TNF signaling pathway|Inflammatory bowel disease (IBD) IL1A 3.7755888039118 3.67063118712625 3.88054642069736 1.05718777585374 0.0802316484640925 1 1 0.06696 0.0256799 0.102976 0 GeneID:3552,Genbank:NM_000575.4,HGNC:HGNC:5991,MIM:147760 interleukin 1 alpha hsa04010,hsa04060,hsa04217,hsa04218,hsa04380,hsa04640,hsa04932,hsa04933,hsa04940,hsa05020,hsa05132,hsa05133,hsa05140,hsa05152,hsa05162,hsa05164,hsa05321,hsa05323,hsa05332,hsa05418 MAPK signaling pathway|Cytokine-cytokine receptor interaction|Necroptosis|Cellular senescence|Osteoclast differentiation|Hematopoietic cell lineage|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Type I diabetes mellitus|Prion diseases|Salmonella infection|Pertussis|Leishmaniasis|Tuberculosis|Measles|Influenza A|Inflammatory bowel disease (IBD)|Rheumatoid arthritis|Graft-versus-host disease|Fluid shear stress and atherosclerosis IL1B 8.36985353268405 11.8959838159236 4.84372324944452 0.407172985807267 -1.29628624696765 0.21728595335059 1 0.270611 0.248119 0.025578 0.190937 GeneID:3553,Genbank:XM_017003988.2,HGNC:HGNC:5992,MIM:147720 interleukin 1 beta hsa01523,hsa04010,hsa04060,hsa04064,hsa04217,hsa04380,hsa04620,hsa04621,hsa04623,hsa04625,hsa04640,hsa04657,hsa04659,hsa04668,hsa04750,hsa04932,hsa04933,hsa04940,hsa05010,hsa05020,hsa05132,hsa05133,hsa05134,hsa05140,hsa05142,hsa05143,hsa05144,hsa05146,hsa05152,hsa05162,hsa05163,hsa05164,hsa05168,hsa05321,hsa05323,hsa05332,hsa05418 Antifolate resistance|MAPK signaling pathway|Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|Hematopoietic cell lineage|IL-17 signaling pathway|Th17 cell differentiation|TNF signaling pathway|Inflammatory mediator regulation of TRP channels|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Type I diabetes mellitus|Alzheimer disease|Prion diseases|Salmonella infection|Pertussis|Legionellosis|Leishmaniasis|Chagas disease (American trypanosomiasis)|African trypanosomiasis|Malaria|Amoebiasis|Tuberculosis|Measles|Human cytomegalovirus infection|Influenza A|Herpes simplex infection|Inflammatory bowel disease (IBD)|Rheumatoid arthritis|Graft-versus-host disease|Fluid shear stress and atherosclerosis IL1R1 152.556278749515 147.566275916395 157.546281582636 1.06763066699532 0.0944126516628034 0.831568869412176 1 0.862779 0.778703 1.15678 0.611613 GeneID:3554,Genbank:XM_011511117.1,HGNC:HGNC:5993,MIM:147810 interleukin 1 receptor type 1 hsa04010,hsa04060,hsa04064,hsa04380,hsa04640,hsa04659,hsa04750,hsa05146,hsa05163,hsa05166,hsa05418 MAPK signaling pathway|Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Osteoclast differentiation|Hematopoietic cell lineage|Th17 cell differentiation|Inflammatory mediator regulation of TRP channels|Amoebiasis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Fluid shear stress and atherosclerosis IL1R2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00490434 0 GeneID:7850,Genbank:XM_006712736.3,HGNC:HGNC:5994,MIM:147811 interleukin 1 receptor type 2 hsa04060,hsa04640,hsa05146,hsa05166,hsa05202,hsa05215,hsa05418 Cytokine-cytokine receptor interaction|Hematopoietic cell lineage|Amoebiasis|Human T-cell leukemia virus 1 infection|Transcriptional misregulation in cancer|Prostate cancer|Fluid shear stress and atherosclerosis IL1RAP 590.972354401957 577.091010742522 604.853698061391 1.04810798782526 0.0677873671367254 0.673503121493641 1 2.64873 2.38782 2.89498 2.25331 GeneID:3556,Genbank:NM_001167931.1,HGNC:HGNC:5995,MIM:602626 interleukin 1 receptor accessory protein GO:0002114,GO:0004871,GO:0004908,GO:0005615,GO:0005886,GO:0005887,GO:0006461,GO:0006954,GO:0006955,GO:0016020,GO:0019221,GO:0032736,GO:0032754,GO:0038172,GO:0042094,GO:0045087,GO:0051092,GO:0051965,GO:0070498,GO:0072602,GO:1900006,GO:1990782,GO:2000778 interleukin-33 receptor activity|signal transducer activity|interleukin-1 receptor activity|extracellular space|plasma membrane|integral component of plasma membrane|protein complex assembly|inflammatory response|immune response|membrane|cytokine-mediated signaling pathway|positive regulation of interleukin-13 production|positive regulation of interleukin-5 production|interleukin-33-mediated signaling pathway|interleukin-2 biosynthetic process|innate immune response|positive regulation of NF-kappaB transcription factor activity|positive regulation of synapse assembly|interleukin-1-mediated signaling pathway|interleukin-4 secretion|positive regulation of dendrite development|protein tyrosine kinase binding|positive regulation of interleukin-6 secretion hsa04010,hsa04060,hsa04659,hsa04750 MAPK signaling pathway|Cytokine-cytokine receptor interaction|Th17 cell differentiation|Inflammatory mediator regulation of TRP channels IL1RAPL1 1.46521110650189 1.96028560782945 0.97013660517434 0.494895540374107 -1.01480405310505 0.813633116358399 1 0 0.0180626 0 0 GeneID:11141,Genbank:NM_014271.3,HGNC:HGNC:5996,MIM:300206 interleukin 1 receptor accessory protein like 1 GO:0005102,GO:0005245,GO:0005737,GO:0005886,GO:0007157,GO:0007165,GO:0009986,GO:0010975,GO:0016021,GO:0030182,GO:0030424,GO:0030425,GO:0045211,GO:0045920,GO:0050775,GO:0051965,GO:0071345,GO:0097105 receptor binding|voltage-gated calcium channel activity|cytoplasm|plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|cell surface|regulation of neuron projection development|integral component of membrane|neuron differentiation|axon|dendrite|postsynaptic membrane|negative regulation of exocytosis|positive regulation of dendrite morphogenesis|positive regulation of synapse assembly|cellular response to cytokine stimulus|presynaptic membrane assembly IL1RAPL2 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0.00837821 0.00803251 0.00806459 0 GeneID:26280,Genbank:NM_017416.1,HGNC:HGNC:5997,MIM:300277 interleukin 1 receptor accessory protein like 2 GO:0004908,GO:0004910,GO:0005886,GO:0007417,GO:0016021 interleukin-1 receptor activity|interleukin-1, Type II, blocking receptor activity|plasma membrane|central nervous system development|integral component of membrane IL1RL1 1.4622745707901 1.47021420587209 1.45433493570811 0.989199349250911 -0.0156668042423989 1 1 0 0.0236982 0.0159828 0.00743698 GeneID:9173,Genbank:NM_016232.4,HGNC:HGNC:5998,MIM:601203 interleukin 1 receptor like 1 GO:0002113,GO:0002114,GO:0002826,GO:0004896,GO:0004908,GO:0005057,GO:0005578,GO:0005886,GO:0006955,GO:0007165,GO:0009897,GO:0016021,GO:0032689,GO:0032754,GO:0038172,GO:0043032,GO:0043124,GO:0050729,GO:0090197 interleukin-33 binding|interleukin-33 receptor activity|negative regulation of T-helper 1 type immune response|cytokine receptor activity|interleukin-1 receptor activity|signal transducer activity, downstream of receptor|proteinaceous extracellular matrix|plasma membrane|immune response|signal transduction|external side of plasma membrane|integral component of membrane|negative regulation of interferon-gamma production|positive regulation of interleukin-5 production|interleukin-33-mediated signaling pathway|positive regulation of macrophage activation|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of inflammatory response|positive regulation of chemokine secretion hsa04060 Cytokine-cytokine receptor interaction IL1RL2 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0219468 GeneID:8808,Genbank:NM_001351449.1,HGNC:HGNC:5999,MIM:604512 interleukin 1 receptor like 2 hsa04060 Cytokine-cytokine receptor interaction IL20RA 1.99950227537901 2.54640955915669 1.45259499160132 0.570448295081951 -0.80983196702256 0.825124353656361 1 0.0114528 0.0323033 0 0.0305875 GeneID:53832,Genbank:NM_001278724.1,HGNC:HGNC:6003,MIM:605620 interleukin 20 receptor subunit alpha GO:0004896,GO:0005886,GO:0016021,GO:0019221,GO:0042015,GO:0045124,GO:2001244 cytokine receptor activity|plasma membrane|integral component of membrane|cytokine-mediated signaling pathway|interleukin-20 binding|regulation of bone resorption|positive regulation of intrinsic apoptotic signaling pathway hsa04060,hsa04630 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway IL20RB 19.8628602836989 17.4308480615094 22.2948725058885 1.27904691884268 0.355069187081259 0.602927558777722 1 0.152299 0.182618 0.249596 0.183924 GeneID:53833,Genbank:NM_144717.3,HGNC:HGNC:6004,MIM:605621 interleukin 20 receptor subunit beta GO:0001808,GO:0002437,GO:0002765,GO:0004920,GO:0005886,GO:0016021,GO:0019221,GO:0032689,GO:0032703,GO:0032733,GO:0032753,GO:0042015,GO:0042130,GO:0048873 negative regulation of type IV hypersensitivity|inflammatory response to antigenic stimulus|immune response-inhibiting signal transduction|interleukin-10 receptor activity|plasma membrane|integral component of membrane|cytokine-mediated signaling pathway|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|positive regulation of interleukin-10 production|positive regulation of interleukin-4 production|interleukin-20 binding|negative regulation of T cell proliferation|homeostasis of number of cells within a tissue hsa04060,hsa04630 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway IL22RA1 4.64292981623927 2.49838328447175 6.78747634800679 2.7167474223003 1.44188044353811 0.351915222296525 1 0.0134468 0.0355673 0.112119 0.04671 GeneID:58985,Genbank:NM_021258.3,HGNC:HGNC:13700,MIM:605457 interleukin 22 receptor subunit alpha 1 hsa04060,hsa04630 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway IL23A 7.4679594264308 10.0895856872569 4.84633316560471 0.480330245049171 -1.057901440989 0.331358468648727 1 0.20179 0.368735 0.0633658 0.147616 GeneID:51561,Genbank:XM_011538477.2,HGNC:HGNC:15488,MIM:605580 interleukin 23 subunit alpha hsa04060,hsa04625,hsa04630,hsa04659,hsa05133,hsa05152,hsa05200,hsa05321,hsa05323 Cytokine-cytokine receptor interaction|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Th17 cell differentiation|Pertussis|Tuberculosis|Pathways in cancer|Inflammatory bowel disease (IBD)|Rheumatoid arthritis IL24 1.72381876005596 0.538097676642304 2.90953984346962 5.40708493971758 2.43485101984636 0.443297956929474 1 0 0 0.104334 0.0195262 GeneID:11009,Genbank:XM_017000121.1,HGNC:HGNC:11346,MIM:604136 interleukin 24 hsa04060,hsa04630 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway IL26 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:55801,Genbank:NM_018402.1,HGNC:HGNC:17119,MIM:605679 interleukin 26 hsa04060 Cytokine-cytokine receptor interaction IL27RA 224.697106842966 259.916071477615 189.478142208317 0.728997407244344 -0.45601441142209 0.0346873034659054 0.730000079237491 3.31699 3.89868 2.62848 2.71513 GeneID:9466,Genbank:NM_004843.3,HGNC:HGNC:17290,MIM:605350 interleukin 27 receptor subunit alpha GO:0002827,GO:0002829,GO:0004888,GO:0005886,GO:0005887,GO:0006955,GO:0007166,GO:0032729,GO:0045509,GO:0048302,GO:0050830,GO:0070106,GO:0070757 positive regulation of T-helper 1 type immune response|negative regulation of type 2 immune response|transmembrane signaling receptor activity|plasma membrane|integral component of plasma membrane|immune response|cell surface receptor signaling pathway|positive regulation of interferon-gamma production|interleukin-27 receptor activity|regulation of isotype switching to IgG isotypes|defense response to Gram-positive bacterium|interleukin-27-mediated signaling pathway|interleukin-35-mediated signaling pathway hsa04060,hsa04630,hsa04659 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|Th17 cell differentiation IL2RA 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0105622 0 0 0 GeneID:3559,Genbank:NM_001308243.1,HGNC:HGNC:6008,MIM:147730 interleukin 2 receptor subunit alpha hsa04060,hsa04144,hsa04151,hsa04630,hsa04640,hsa04658,hsa04659,hsa05162,hsa05166,hsa05200 Cytokine-cytokine receptor interaction|Endocytosis|PI3K-Akt signaling pathway|Jak-STAT signaling pathway|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Measles|Human T-cell leukemia virus 1 infection|Pathways in cancer IL2RB 2.22346137472701 3.47852608838648 0.968396661067546 0.278392812490516 -1.84480613053314 0.455030756033866 1 0.0107915 0.056775 0 0.018807 GeneID:3560,Genbank:NM_001346222.1,HGNC:HGNC:6009,MIM:146710 interleukin 2 receptor subunit beta hsa04060,hsa04144,hsa04151,hsa04630,hsa04658,hsa04659,hsa05162,hsa05166,hsa05200,hsa05202 Cytokine-cytokine receptor interaction|Endocytosis|PI3K-Akt signaling pathway|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Measles|Human T-cell leukemia virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer IL2RG 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0430981 0 0 GeneID:3561,Genbank:NM_000206.2,HGNC:HGNC:6010,MIM:308380 interleukin 2 receptor subunit gamma hsa04060,hsa04144,hsa04151,hsa04630,hsa04658,hsa04659,hsa05162,hsa05166,hsa05200,hsa05321,hsa05340 Cytokine-cytokine receptor interaction|Endocytosis|PI3K-Akt signaling pathway|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Measles|Human T-cell leukemia virus 1 infection|Pathways in cancer|Inflammatory bowel disease (IBD)|Primary immunodeficiency IL31 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0447655 GeneID:386653,Genbank:NM_001014336.1,HGNC:HGNC:19372,MIM:609509 interleukin 31 GO:0002376,GO:0005125,GO:0005576,GO:0005615,GO:0019221 immune system process|cytokine activity|extracellular region|extracellular space|cytokine-mediated signaling pathway hsa04060 Cytokine-cytokine receptor interaction IL31RA 181.89582193241 146.634159387165 217.157484477654 1.4809474503433 0.566520449219482 0.137513716756949 1 0.532517 0.465477 0.924073 0.578131 GeneID:133396,Genbank:XM_011543142.2,HGNC:HGNC:18969,MIM:609510 interleukin 31 receptor A GO:0000165,GO:0002067,GO:0002438,GO:0003713,GO:0004896,GO:0005622,GO:0005886,GO:0006952,GO:0007169,GO:0007259,GO:0008284,GO:0009897,GO:0016021,GO:0019221,GO:0019901,GO:0019955,GO:0030054,GO:0030224,GO:0030225,GO:0030424,GO:0035745,GO:0042531,GO:0042592,GO:0042734,GO:0043031,GO:0043066,GO:0045893,GO:0098542 MAPK cascade|glandular epithelial cell differentiation|acute inflammatory response to antigenic stimulus|transcription coactivator activity|cytokine receptor activity|intracellular|plasma membrane|defense response|transmembrane receptor protein tyrosine kinase signaling pathway|JAK-STAT cascade|positive regulation of cell proliferation|external side of plasma membrane|integral component of membrane|cytokine-mediated signaling pathway|protein kinase binding|cytokine binding|cell junction|monocyte differentiation|macrophage differentiation|axon|T-helper 2 cell cytokine production|positive regulation of tyrosine phosphorylation of STAT protein|homeostatic process|presynaptic membrane|negative regulation of macrophage activation|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|defense response to other organism hsa04060 Cytokine-cytokine receptor interaction IL32 113.168180074087 144.933622462976 81.402737685198 0.561655303316474 -0.832243097470953 0.00326584115115533 0.215249843114831 2.80445 2.98612 1.4149 1.80228 GeneID:9235,Genbank:NM_001012631.1,HGNC:HGNC:16830,MIM:606001 interleukin 32 GO:0005125,GO:0005615,GO:0005829,GO:0006952,GO:0006955,GO:0007155,GO:0016020,GO:0019221 cytokine activity|extracellular space|cytosol|defense response|immune response|cell adhesion|membrane|cytokine-mediated signaling pathway hsa04060 Cytokine-cytokine receptor interaction IL33 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.011885 0 0 0 GeneID:90865,Genbank:XM_017015285.1,HGNC:HGNC:16028,MIM:608678 interleukin 33 GO:0002282,GO:0002686,GO:0002826,GO:0002830,GO:0005125,GO:0005576,GO:0005615,GO:0005654,GO:0005694,GO:0006351,GO:0016579,GO:0030133,GO:0032436,GO:0032689,GO:0032736,GO:0032753,GO:0032754,GO:0032755,GO:0038172,GO:0042092,GO:0043032,GO:0045944,GO:0050729,GO:0051024,GO:0051025,GO:0051607,GO:0061518,GO:0090197,GO:0097191 microglial cell activation involved in immune response|negative regulation of leukocyte migration|negative regulation of T-helper 1 type immune response|positive regulation of type 2 immune response|cytokine activity|extracellular region|extracellular space|nucleoplasm|chromosome|transcription, DNA-templated|protein deubiquitination|transport vesicle|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of interferon-gamma production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|positive regulation of interleukin-6 production|interleukin-33-mediated signaling pathway|type 2 immune response|positive regulation of macrophage activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of inflammatory response|positive regulation of immunoglobulin secretion|negative regulation of immunoglobulin secretion|defense response to virus|microglial cell proliferation|positive regulation of chemokine secretion|extrinsic apoptotic signaling pathway hsa04060,hsa04217,hsa04623,hsa05164 Cytokine-cytokine receptor interaction|Necroptosis|Cytosolic DNA-sensing pathway|Influenza A IL34 5.10008301343849 7.29323609956755 2.90692992730943 0.398578887015847 -1.32706280318569 0.357803155571421 1 0.258814 0.0744332 0.0530645 0.074574 GeneID:146433,Genbank:NM_152456.2,HGNC:HGNC:28529,MIM:612081 interleukin 34 GO:0001934,GO:0005125,GO:0005157,GO:0005576,GO:0005615,GO:0006954,GO:0008083,GO:0008284,GO:0019221,GO:0042802,GO:0045087,GO:0045651,GO:0045657 positive regulation of protein phosphorylation|cytokine activity|macrophage colony-stimulating factor receptor binding|extracellular region|extracellular space|inflammatory response|growth factor activity|positive regulation of cell proliferation|cytokine-mediated signaling pathway|identical protein binding|innate immune response|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation hsa04060 Cytokine-cytokine receptor interaction IL36B 1.21136579838783 0 2.42273159677566 Inf Inf 0.33960385030001 1 0 0 0.0362299 0.0339116 GeneID:27177,Genbank:NM_014438.4,HGNC:HGNC:15564,MIM:605508 interleukin 36 beta GO:0001819,GO:0005125,GO:0005149,GO:0005615,GO:0006954,GO:0019221,GO:0032755,GO:0045087,GO:0045582 positive regulation of cytokine production|cytokine activity|interleukin-1 receptor binding|extracellular space|inflammatory response|cytokine-mediated signaling pathway|positive regulation of interleukin-6 production|innate immune response|positive regulation of T cell differentiation hsa04060 Cytokine-cytokine receptor interaction IL36RN 0.977641254229628 1.47021420587209 0.48506830258717 0.329930360249405 -1.59976655382621 0.793472162274683 1 0 0.0283247 0.0145065 0 GeneID:26525,Genbank:NM_173170.1,HGNC:HGNC:15561,MIM:605507 interleukin 36 receptor antagonist hsa04060 Cytokine-cytokine receptor interaction IL37 2.28843112372584 2.15239070656922 2.42447154088245 1.12640866432048 0.171730336321618 1 1 0.0346202 0 0.0222036 0.0103448 GeneID:27178,Genbank:XM_011510964.3,HGNC:HGNC:15563,MIM:605510 interleukin 37 hsa04060 Cytokine-cytokine receptor interaction IL3RA 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:3563,Genbank:XM_017029491.2,HGNC:HGNC:6012,MIM:430000 interleukin 3 receptor subunit alpha hsa04060,hsa04151,hsa04210,hsa04630,hsa04640,hsa05200 Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Apoptosis|Jak-STAT signaling pathway|Hematopoietic cell lineage|Pathways in cancer IL4I1 25.893234016639 30.4608621605105 21.3256058727675 0.700098564525009 -0.514370046342415 0.350363609227604 1 1.20585 1.59198 1.51471 1.18824 GeneID:259307,Genbank:NM_001258017.1,HGNC:HGNC:19094,MIM:609742 interleukin 4 induced 1 GO:0001716,GO:0005576,GO:0005764,GO:0006559 L-amino-acid oxidase activity|extracellular region|lysosome|L-phenylalanine catabolic process hsa00250,hsa00270,hsa00280,hsa00350,hsa00360,hsa00380,hsa00400 Alanine, aspartate and glutamate metabolism|Cysteine and methionine metabolism|Valine, leucine and isoleucine degradation|Tyrosine metabolism|Phenylalanine metabolism|Tryptophan metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis IL4R 151.985214553308 191.066960831014 112.903468275602 0.590910473399206 -0.758988525172775 0.00244366626128203 0.180198768353117 1.01267 1.14658 0.478186 0.695093 GeneID:3566,Genbank:XM_011545825.1,HGNC:HGNC:6015,MIM:147781 interleukin 4 receptor hsa04060,hsa04151,hsa04630,hsa04640,hsa04658,hsa04659,hsa05200,hsa05321 Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Jak-STAT signaling pathway|Hematopoietic cell lineage|Th1 and Th2 cell differentiation|Th17 cell differentiation|Pathways in cancer|Inflammatory bowel disease (IBD) IL5 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0111818 0 0 GeneID:3567,Genbank:XM_005271988.4,HGNC:HGNC:6016,MIM:147850 interleukin 5 hsa04060,hsa04630,hsa04640,hsa04657,hsa04658,hsa04660,hsa04664,hsa04672,hsa05200,hsa05310,hsa05320,hsa05321,hsa05330 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|Hematopoietic cell lineage|IL-17 signaling pathway|Th1 and Th2 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Intestinal immune network for IgA production|Pathways in cancer|Asthma|Autoimmune thyroid disease|Inflammatory bowel disease (IBD)|Allograft rejection IL6 80.8427549240294 73.4900759825337 88.1954338655252 1.20009991398684 0.263154522011105 0.422120490250781 1 0.504337 0.461056 0.532074 0.57885 GeneID:3569,Genbank:XM_011515390.2,HGNC:HGNC:6018,MIM:147620 interleukin 6 hsa01521,hsa01523,hsa04060,hsa04066,hsa04068,hsa04151,hsa04218,hsa04620,hsa04621,hsa04623,hsa04625,hsa04630,hsa04640,hsa04657,hsa04659,hsa04668,hsa04672,hsa04931,hsa04932,hsa04933,hsa05020,hsa05132,hsa05133,hsa05134,hsa05142,hsa05143,hsa05144,hsa05146,hsa05152,hsa05161,hsa05162,hsa05163,hsa05164,hsa05166,hsa05167,hsa05168,hsa05169,hsa05200,hsa05202,hsa05321,hsa05323,hsa05332,hsa05410 EGFR tyrosine kinase inhibitor resistance|Antifolate resistance|Cytokine-cytokine receptor interaction|HIF-1 signaling pathway|FoxO signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Hematopoietic cell lineage|IL-17 signaling pathway|Th17 cell differentiation|TNF signaling pathway|Intestinal immune network for IgA production|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Prion diseases|Salmonella infection|Pertussis|Legionellosis|Chagas disease (American trypanosomiasis)|African trypanosomiasis|Malaria|Amoebiasis|Tuberculosis|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Inflammatory bowel disease (IBD)|Rheumatoid arthritis|Graft-versus-host disease|Hypertrophic cardiomyopathy (HCM) IL6R 102.204855244972 93.4291159836228 110.980594506321 1.18785876691561 0.248363313930758 0.419693670763655 1 0.54008 0.663684 0.708727 0.662042 GeneID:3570,Genbank:NM_000565.3,HGNC:HGNC:6019,MIM:147880 interleukin 6 receptor GO:0002384,GO:0002446,GO:0002548,GO:0002690,GO:0004896,GO:0005576,GO:0005615,GO:0005886,GO:0005896,GO:0006953,GO:0008284,GO:0010536,GO:0016323,GO:0016324,GO:0019221,GO:0019899,GO:0019981,GO:0031018,GO:0032717,GO:0032722,GO:0032755,GO:0032966,GO:0034097,GO:0042531,GO:0042803,GO:0043410,GO:0045669,GO:0048661,GO:0050731,GO:0050829,GO:0050830,GO:0070102,GO:0070110,GO:0070119,GO:0070120,GO:0097191 hepatic immune response|neutrophil mediated immunity|monocyte chemotaxis|positive regulation of leukocyte chemotaxis|cytokine receptor activity|extracellular region|extracellular space|plasma membrane|interleukin-6 receptor complex|acute-phase response|positive regulation of cell proliferation|positive regulation of activation of Janus kinase activity|basolateral plasma membrane|apical plasma membrane|cytokine-mediated signaling pathway|enzyme binding|interleukin-6 binding|endocrine pancreas development|negative regulation of interleukin-8 production|positive regulation of chemokine production|positive regulation of interleukin-6 production|negative regulation of collagen biosynthetic process|response to cytokine|positive regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|positive regulation of MAPK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|interleukin-6-mediated signaling pathway|ciliary neurotrophic factor receptor complex|ciliary neurotrophic factor binding|ciliary neurotrophic factor-mediated signaling pathway|extrinsic apoptotic signaling pathway hsa01521,hsa04060,hsa04066,hsa04151,hsa04630,hsa04640,hsa04659,hsa04932,hsa05163,hsa05200 EGFR tyrosine kinase inhibitor resistance|Cytokine-cytokine receptor interaction|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Jak-STAT signaling pathway|Hematopoietic cell lineage|Th17 cell differentiation|Non-alcoholic fatty liver disease (NAFLD)|Human cytomegalovirus infection|Pathways in cancer IL6ST 909.142797865573 1044.65596747513 773.629628256017 0.740559238967288 -0.433312950398189 0.277769049370849 1 5.11033 3.89493 4.32261 2.55728 GeneID:3572,Genbank:NM_175767.2,HGNC:HGNC:6021,MIM:600694 interleukin 6 signal transducer GO:0002675,GO:0002821,GO:0004897,GO:0004921,GO:0005127,GO:0005576,GO:0005615,GO:0005886,GO:0005896,GO:0005900,GO:0005977,GO:0008284,GO:0008593,GO:0009897,GO:0010575,GO:0010613,GO:0016020,GO:0016032,GO:0019221,GO:0019838,GO:0019970,GO:0030425,GO:0034097,GO:0038165,GO:0042102,GO:0042531,GO:0042803,GO:0043025,GO:0043066,GO:0045509,GO:0045669,GO:0048711,GO:0048861,GO:0070062,GO:0070102,GO:0070104,GO:0070106,GO:0070110,GO:0070120,GO:0070757 positive regulation of acute inflammatory response|positive regulation of adaptive immune response|ciliary neurotrophic factor receptor activity|interleukin-11 receptor activity|ciliary neurotrophic factor receptor binding|extracellular region|extracellular space|plasma membrane|interleukin-6 receptor complex|oncostatin-M receptor complex|glycogen metabolic process|positive regulation of cell proliferation|regulation of Notch signaling pathway|external side of plasma membrane|positive regulation of vascular endothelial growth factor production|positive regulation of cardiac muscle hypertrophy|membrane|viral process|cytokine-mediated signaling pathway|growth factor binding|interleukin-11 binding|dendrite|response to cytokine|oncostatin-M-mediated signaling pathway|positive regulation of T cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|neuronal cell body|negative regulation of apoptotic process|interleukin-27 receptor activity|positive regulation of osteoblast differentiation|positive regulation of astrocyte differentiation|leukemia inhibitory factor signaling pathway|extracellular exosome|interleukin-6-mediated signaling pathway|negative regulation of interleukin-6-mediated signaling pathway|interleukin-27-mediated signaling pathway|ciliary neurotrophic factor receptor complex|ciliary neurotrophic factor-mediated signaling pathway|interleukin-35-mediated signaling pathway hsa04060,hsa04550,hsa04630,hsa04659,hsa05167,hsa05200,hsa05203 Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells|Jak-STAT signaling pathway|Th17 cell differentiation|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Viral carcinogenesis IL7 12.5707382216509 13.5102768458505 11.6311995974513 0.860914970889267 -0.216057339418612 0.854831705131052 1 0.0965036 0.0835648 0.111124 0.0689265 GeneID:3574,Genbank:XM_011517523.3,HGNC:HGNC:6023,MIM:146660 interleukin 7 hsa04060,hsa04151,hsa04630,hsa04640,hsa05200 Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Jak-STAT signaling pathway|Hematopoietic cell lineage|Pathways in cancer IL7R 823.957543946586 839.5710750878 808.344012805371 0.962805933638003 -0.0546830619202553 0.792079083039194 1 6.79079 5.70433 6.06039 6.02208 GeneID:3575,Genbank:NM_002185.4,HGNC:HGNC:6024,MIM:146661 interleukin 7 receptor hsa04060,hsa04068,hsa04151,hsa04630,hsa04640,hsa05200,hsa05340 Cytokine-cytokine receptor interaction|FoxO signaling pathway|PI3K-Akt signaling pathway|Jak-STAT signaling pathway|Hematopoietic cell lineage|Pathways in cancer|Primary immunodeficiency IL9R 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:3581,Genbank:NM_176786.1,HGNC:HGNC:6030,MIM:300007 interleukin 9 receptor hsa04060,hsa04630,hsa04640 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|Hematopoietic cell lineage ILDR2 1002.25895755402 878.084802088584 1126.43311301945 1.28282952892495 0.359329468077782 0.150540044671289 1 3.03059 2.70725 4.47962 3.09401 GeneID:387597,Genbank:NM_199351.2,HGNC:HGNC:18131 immunoglobulin like domain containing receptor 2 GO:0005789,GO:0009749,GO:0016021,GO:0030073,GO:0030154,GO:0031016,GO:0048873 endoplasmic reticulum membrane|response to glucose|integral component of membrane|insulin secretion|cell differentiation|pancreas development|homeostasis of number of cells within a tissue ILF2 8320.87622683612 8380.48104250463 8261.27141116762 0.985775323548565 -0.0206692277346746 0.869222693572213 1 131.155 135.453 131.707 132.646 GeneID:3608,Genbank:NM_004515.3,HGNC:HGNC:6037,MIM:603181 interleukin enhancer binding factor 2 GO:0003677,GO:0003723,GO:0003725,GO:0005524,GO:0005576,GO:0005634,GO:0005730,GO:0006351,GO:0016020,GO:0016740,GO:0030529,GO:0035580,GO:0043312,GO:0045893,GO:1904724,GO:1904813 DNA binding|RNA binding|double-stranded RNA binding|ATP binding|extracellular region|nucleus|nucleolus|transcription, DNA-templated|membrane|transferase activity|intracellular ribonucleoprotein complex|specific granule lumen|neutrophil degranulation|positive regulation of transcription, DNA-templated|tertiary granule lumen|ficolin-1-rich granule lumen ILF3 13254.8110251316 13345.8017487139 13163.8203015492 0.986364142777541 -0.0198077403790689 0.875733717513587 1 58.2728 58.1254 58.917 57.9142 GeneID:3609,Genbank:NM_017620.2,HGNC:HGNC:6038,MIM:603182 interleukin enhancer binding factor 3 GO:0003677,GO:0003723,GO:0003725,GO:0005576,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0006351,GO:0006468,GO:0016020,GO:0017148,GO:0030529,GO:0045071,GO:0045892,GO:0045893,GO:0051607 DNA binding|RNA binding|double-stranded RNA binding|extracellular region|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrion|transcription, DNA-templated|protein phosphorylation|membrane|negative regulation of translation|intracellular ribonucleoprotein complex|negative regulation of viral genome replication|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|defense response to virus ILK 2416.6537088992 2242.56732394484 2590.74009385355 1.15525632884735 0.208212993050591 0.147730745521201 1 19.1103 22.4412 23.9451 25.2994 GeneID:3611,Genbank:NM_004517.3,HGNC:HGNC:6040,MIM:602366 integrin linked kinase GO:0000165,GO:0001658,GO:0001725,GO:0001934,GO:0001954,GO:0003151,GO:0004674,GO:0004871,GO:0005178,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0006468,GO:0006469,GO:0007050,GO:0007160,GO:0007229,GO:0007275,GO:0007569,GO:0008283,GO:0008284,GO:0009967,GO:0010667,GO:0010761,GO:0014912,GO:0016020,GO:0017124,GO:0018105,GO:0019901,GO:0021675,GO:0022011,GO:0030017,GO:0030027,GO:0030054,GO:0030335,GO:0030513,GO:0032288,GO:0032956,GO:0033209,GO:0034329,GO:0034446,GO:0042327,GO:0043025,GO:0043034,GO:0043195,GO:0043198,GO:0043234,GO:0043406,GO:0043491,GO:0043524,GO:0045197,GO:0045663,GO:0045669,GO:0045773,GO:0045893,GO:0048662,GO:0048812,GO:0050775,GO:0051291,GO:0051897,GO:0070527,GO:0090263,GO:0097435,GO:1901224,GO:2000178 MAPK cascade|branching involved in ureteric bud morphogenesis|stress fiber|positive regulation of protein phosphorylation|positive regulation of cell-matrix adhesion|outflow tract morphogenesis|protein serine/threonine kinase activity|signal transducer activity|integrin binding|ATP binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|cell-cell junction|focal adhesion|protein phosphorylation|negative regulation of protein kinase activity|cell cycle arrest|cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organism development|cell aging|cell proliferation|positive regulation of cell proliferation|positive regulation of signal transduction|negative regulation of cardiac muscle cell apoptotic process|fibroblast migration|negative regulation of smooth muscle cell migration|membrane|SH3 domain binding|peptidyl-serine phosphorylation|protein kinase binding|nerve development|myelination in peripheral nervous system|sarcomere|lamellipodium|cell junction|positive regulation of cell migration|positive regulation of BMP signaling pathway|myelin assembly|regulation of actin cytoskeleton organization|tumor necrosis factor-mediated signaling pathway|cell junction assembly|substrate adhesion-dependent cell spreading|positive regulation of phosphorylation|neuronal cell body|costamere|terminal bouton|dendritic shaft|protein complex|positive regulation of MAP kinase activity|protein kinase B signaling|negative regulation of neuron apoptotic process|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of myoblast differentiation|positive regulation of osteoblast differentiation|positive regulation of axon extension|positive regulation of transcription, DNA-templated|negative regulation of smooth muscle cell proliferation|neuron projection morphogenesis|positive regulation of dendrite morphogenesis|protein heterooligomerization|positive regulation of protein kinase B signaling|platelet aggregation|positive regulation of canonical Wnt signaling pathway|supramolecular fiber organization|positive regulation of NIK/NF-kappaB signaling|negative regulation of neural precursor cell proliferation hsa03320,hsa04360,hsa04510,hsa05100,hsa05213 PPAR signaling pathway|Axon guidance|Focal adhesion|Bacterial invasion of epithelial cells|Endometrial cancer ILKAP 534.496994708491 543.182065459804 525.811923957177 0.968021511373128 -0.0468889874634126 0.764322817419228 1 4.64421 5.44228 5.0877 5.00337 GeneID:80895,Genbank:XM_017005057.1,HGNC:HGNC:15566 ILK associated serine/threonine phosphatase GO:0004722,GO:0005634,GO:0005654,GO:0005829,GO:0046872 protein serine/threonine phosphatase activity|nucleus|nucleoplasm|cytosol|metal ion binding ILVBL 1527.98750501771 1486.36992876956 1569.60508126586 1.05599894809848 0.0786083975998992 0.602739131485619 1 19.3296 20.2415 21.1524 22.8061 GeneID:10994,Genbank:NM_006844.4,HGNC:HGNC:6041,MIM:605770 ilvB acetolactate synthase like GO:0000287,GO:0016020,GO:0016021,GO:0016740,GO:0030976 magnesium ion binding|membrane|integral component of membrane|transferase activity|thiamine pyrophosphate binding IMMP1L 231.038339850435 225.121001938642 236.955677762228 1.05257028763052 0.0739165755531411 0.732674173631391 1 3.23761 2.90723 3.06703 3.37966 GeneID:196294,Genbank:NM_001304274.1,HGNC:HGNC:26317,MIM:612323 inner mitochondrial membrane peptidase subunit 1 GO:0005739,GO:0006465,GO:0006627,GO:0008236,GO:0033108,GO:0042720 mitochondrion|signal peptide processing|protein processing involved in protein targeting to mitochondrion|serine-type peptidase activity|mitochondrial respiratory chain complex assembly|mitochondrial inner membrane peptidase complex hsa03060 Protein export IMMP2L 114.557969757241 118.633462891549 110.482476622933 0.931292688673622 -0.102693442531288 0.73305481481737 1 0.0475136 0.0338765 0.0488358 0.0538237 GeneID:83943,Genbank:XM_024446956.1,HGNC:HGNC:14598,MIM:605977 inner mitochondrial membrane peptidase subunit 2 GO:0001541,GO:0006465,GO:0006627,GO:0006801,GO:0006974,GO:0007283,GO:0007420,GO:0008015,GO:0008233,GO:0008236,GO:0016021,GO:0022904,GO:0030728,GO:0033108,GO:0042720,GO:0061300 ovarian follicle development|signal peptide processing|protein processing involved in protein targeting to mitochondrion|superoxide metabolic process|cellular response to DNA damage stimulus|spermatogenesis|brain development|blood circulation|peptidase activity|serine-type peptidase activity|integral component of membrane|respiratory electron transport chain|ovulation|mitochondrial respiratory chain complex assembly|mitochondrial inner membrane peptidase complex|cerebellum vasculature development hsa03060 Protein export IMMT 2208.02796633332 2230.40752344186 2185.64840922479 0.97993231562096 -0.0292459898331927 0.841393560194121 1 21.1339 21.3312 21.2036 20.8463 GeneID:10989,Genbank:NM_001100170.1,HGNC:HGNC:6047,MIM:600378 inner membrane mitochondrial protein GO:0003723,GO:0005739,GO:0005743,GO:0016020,GO:0042407,GO:0043209,GO:0051560,GO:0061617 RNA binding|mitochondrion|mitochondrial inner membrane|membrane|cristae formation|myelin sheath|mitochondrial calcium ion homeostasis|MICOS complex IMP3 1380.81121585903 1344.62769174772 1416.99473997033 1.05381939451846 0.0756276364639241 0.665252953053863 1 67.3399 79.2417 76.9509 80.4145 GeneID:55272,Genbank:NM_018285.3,HGNC:HGNC:14497,MIM:612980 IMP3, U3 small nucleolar ribonucleoprotein GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0030515,GO:0032040,GO:0034457 RNA binding|nucleus|nucleoplasm|nucleolus|rRNA processing|snoRNA binding|small-subunit processome|Mpp10 complex hsa03008 Ribosome biogenesis in eukaryotes IMP4 1724.80998041305 1846.05661849092 1603.56334233518 0.86864255747802 -0.203165458284319 0.148479886880061 1 11.9648 13.7196 11.5795 11.5778 GeneID:92856,Genbank:NM_001320309.1,HGNC:HGNC:30856,MIM:612981 IMP4, U3 small nucleolar ribonucleoprotein GO:0001650,GO:0005654,GO:0005730,GO:0006364,GO:0030515,GO:0032040,GO:0034457,GO:0042134 fibrillar center|nucleoplasm|nucleolus|rRNA processing|snoRNA binding|small-subunit processome|Mpp10 complex|rRNA primary transcript binding hsa03008 Ribosome biogenesis in eukaryotes IMPA1 613.939038139254 657.422469042243 570.455607236265 0.86771540995142 -0.204706144353679 0.232051136787517 1 9.52117 8.95223 8.41243 7.18222 GeneID:3612,Genbank:NM_001144879.1,HGNC:HGNC:6050,MIM:602064 inositol monophosphatase 1 GO:0000287,GO:0005737,GO:0005829,GO:0006020,GO:0006021,GO:0006661,GO:0006796,GO:0007165,GO:0008934,GO:0030145,GO:0031403,GO:0042802,GO:0042803,GO:0043647,GO:0046854,GO:0046855,GO:0052832,GO:0052833,GO:0052834,GO:0070062 magnesium ion binding|cytoplasm|cytosol|inositol metabolic process|inositol biosynthetic process|phosphatidylinositol biosynthetic process|phosphate-containing compound metabolic process|signal transduction|inositol monophosphate 1-phosphatase activity|manganese ion binding|lithium ion binding|identical protein binding|protein homodimerization activity|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|inositol monophosphate 3-phosphatase activity|inositol monophosphate 4-phosphatase activity|inositol monophosphate phosphatase activity|extracellular exosome hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system IMPA2 872.24675197376 789.309511098567 955.183992848954 1.21015137841114 0.275187526196602 0.0937189289045263 0.992070300948377 14.6428 18.0065 20.4551 20.9323 GeneID:3613,Genbank:NM_014214.2,HGNC:HGNC:6051,MIM:605922 inositol monophosphatase 2 GO:0005737,GO:0005829,GO:0006020,GO:0006021,GO:0006796,GO:0007165,GO:0008934,GO:0042803,GO:0043647,GO:0046854,GO:0046855,GO:0046872,GO:0052832,GO:0052833 cytoplasm|cytosol|inositol metabolic process|inositol biosynthetic process|phosphate-containing compound metabolic process|signal transduction|inositol monophosphate 1-phosphatase activity|protein homodimerization activity|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol phosphate dephosphorylation|metal ion binding|inositol monophosphate 3-phosphatase activity|inositol monophosphate 4-phosphatase activity hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system IMPACT 49.9289314964617 49.4481683221539 50.4096946707696 1.01944513581072 0.0277841349193428 0.961380175283614 1 0.501364 0.431438 0.537759 0.352912 GeneID:55364,Genbank:NM_018439.3,HGNC:HGNC:20387,MIM:615319 impact RWD domain protein GO:0000122,GO:0001933,GO:0003779,GO:0005737,GO:0005844,GO:0031333,GO:0031953,GO:0034198,GO:0042149,GO:0043022,GO:0045666,GO:0060548,GO:0060733,GO:0070301,GO:0071264,GO:0071468,GO:0071494,GO:0072755,GO:0097201,GO:1990138,GO:1990253 negative regulation of transcription from RNA polymerase II promoter|negative regulation of protein phosphorylation|actin binding|cytoplasm|polysome|negative regulation of protein complex assembly|negative regulation of protein autophosphorylation|cellular response to amino acid starvation|cellular response to glucose starvation|ribosome binding|positive regulation of neuron differentiation|negative regulation of cell death|regulation of eIF2 alpha phosphorylation by amino acid starvation|cellular response to hydrogen peroxide|positive regulation of translational initiation in response to starvation|cellular response to acidic pH|cellular response to UV-C|cellular response to benomyl|negative regulation of transcription from RNA polymerase II promoter in response to stress|neuron projection extension|cellular response to leucine starvation IMPAD1 2562.20712774173 2614.72021077321 2509.69404471025 0.959832732530909 -0.0591450817344847 0.761913920885729 1 18.1836 17.3498 19.6647 14.4972 GeneID:54928,Genbank:NM_017813.4,HGNC:HGNC:26019,MIM:614010 inositol monophosphatase domain containing 1 GO:0001958,GO:0002063,GO:0005634,GO:0005794,GO:0005796,GO:0005829,GO:0006021,GO:0008254,GO:0008441,GO:0008934,GO:0009791,GO:0016020,GO:0016021,GO:0016604,GO:0030204,GO:0042733,GO:0046854,GO:0046872,GO:0050427,GO:0052832,GO:0052833 endochondral ossification|chondrocyte development|nucleus|Golgi apparatus|Golgi lumen|cytosol|inositol biosynthetic process|3'-nucleotidase activity|3'(2'),5'-bisphosphate nucleotidase activity|inositol monophosphate 1-phosphatase activity|post-embryonic development|membrane|integral component of membrane|nuclear body|chondroitin sulfate metabolic process|embryonic digit morphogenesis|phosphatidylinositol phosphorylation|metal ion binding|3'-phosphoadenosine 5'-phosphosulfate metabolic process|inositol monophosphate 3-phosphatase activity|inositol monophosphate 4-phosphatase activity hsa00562,hsa00920,hsa04070 Inositol phosphate metabolism|Sulfur metabolism|Phosphatidylinositol signaling system IMPDH1 1446.55406691271 1575.94611712243 1317.16201670298 0.835791276359139 -0.258785394397763 0.0703963426399891 0.921133842910185 17.8514 18.9969 15.7322 16.1083 GeneID:3614,Genbank:XM_024446757.1,HGNC:HGNC:6052,MIM:146690 inosine monophosphate dehydrogenase 1 hsa00230,hsa00983 Purine metabolism|Drug metabolism - other enzymes IMPDH2 8727.32440422653 9203.03999069799 8251.60881775507 0.896617729152042 -0.157435068277202 0.264525126767643 1 124.302 133.339 111.213 126.181 GeneID:3615,Genbank:XM_006713128.3,HGNC:HGNC:6053,MIM:146691 inosine monophosphate dehydrogenase 2 GO:0000166,GO:0003677,GO:0003723,GO:0003938,GO:0005576,GO:0005634,GO:0005737,GO:0005778,GO:0005829,GO:0006177,GO:0006183,GO:0007623,GO:0009168,GO:0016020,GO:0034774,GO:0043312,GO:0046651,GO:0046872,GO:0051289,GO:0060041,GO:0070062,GO:0071353,GO:1904813 nucleotide binding|DNA binding|RNA binding|IMP dehydrogenase activity|extracellular region|nucleus|cytoplasm|peroxisomal membrane|cytosol|GMP biosynthetic process|GTP biosynthetic process|circadian rhythm|purine ribonucleoside monophosphate biosynthetic process|membrane|secretory granule lumen|neutrophil degranulation|lymphocyte proliferation|metal ion binding|protein homotetramerization|retina development in camera-type eye|extracellular exosome|cellular response to interleukin-4|ficolin-1-rich granule lumen hsa00230,hsa00983 Purine metabolism|Drug metabolism - other enzymes IMPG1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00881705 GeneID:3617,Genbank:NM_001282368.1,HGNC:HGNC:6055,MIM:602870 interphotoreceptor matrix proteoglycan 1 GO:0005201,GO:0005578,GO:0007601 extracellular matrix structural constituent|proteinaceous extracellular matrix|visual perception IMPG2 3.48415840587988 3.57457863775636 3.3937381740034 0.949409292093103 -0.0748979250536205 1 1 0.0101849 0.0195638 0.0245485 0.00456953 GeneID:50939,Genbank:NM_016247.3,HGNC:HGNC:18362,MIM:607056 interphotoreceptor matrix proteoglycan 2 GO:0005201,GO:0005540,GO:0005578,GO:0007601,GO:0008201,GO:0016021,GO:0033165,GO:0043235 extracellular matrix structural constituent|hyaluronic acid binding|proteinaceous extracellular matrix|visual perception|heparin binding|integral component of membrane|interphotoreceptor matrix|receptor complex INA 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0139537 0 0 GeneID:9118,Genbank:NM_032727.3,HGNC:HGNC:6057,MIM:605338 internexin neuronal intermediate filament protein alpha GO:0005200,GO:0005615,GO:0005654,GO:0005883,GO:0021762,GO:0030154,GO:0031965,GO:0036464,GO:0043209,GO:0045111,GO:0060052,GO:1990830 structural constituent of cytoskeleton|extracellular space|nucleoplasm|neurofilament|substantia nigra development|cell differentiation|nuclear membrane|cytoplasmic ribonucleoprotein granule|myelin sheath|intermediate filament cytoskeleton|neurofilament cytoskeleton organization|cellular response to leukemia inhibitory factor INAFM1 376.324376789203 339.767267030486 412.88148654792 1.21518912094282 0.28118085919218 0.138971794772771 1 35.7038 36.0986 41.3796 45.0276 GeneID:255783,Genbank:NM_178511.5,HGNC:HGNC:27406 InaF motif containing 1 GO:0016021 integral component of membrane INAFM2 1032.10950496385 977.616305959759 1086.60270396794 1.11148177188103 0.152484288596592 0.312150889368584 1 16.6902 15.7104 19.9248 16.5759 GeneID:100505573,Genbank:XM_011521149.3,HGNC:HGNC:35165 InaF motif containing 2 GO:0016021 integral component of membrane INAVA 21.0054498253227 18.2669120413693 23.7439876092762 1.29983587568074 0.378329472261798 0.580540905166947 1 0.114154 0.139614 0.155605 0.199276 GeneID:55765,Genbank:XM_011509755.1,HGNC:HGNC:25599 innate immunity activator GO:0000187,GO:0002221,GO:0002367,GO:0005634,GO:0005737,GO:0032494,GO:0032495,GO:0032731,GO:0032733,GO:0032755,GO:0032874,GO:0043123,GO:0045087,GO:0070431,GO:1903409 activation of MAPK activity|pattern recognition receptor signaling pathway|cytokine production involved in immune response|nucleus|cytoplasm|response to peptidoglycan|response to muramyl dipeptide|positive regulation of interleukin-1 beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-6 production|positive regulation of stress-activated MAPK cascade|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|nucleotide-binding oligomerization domain containing 2 signaling pathway|reactive oxygen species biosynthetic process INCA1 8.97119060887726 10.1856382366268 7.75674298112774 0.761537254802068 -0.393013479050044 0.720217446885718 1 0.0440175 0.0953501 0.182556 0.0762181 GeneID:388324,Genbank:XM_024450745.1,HGNC:HGNC:32224,MIM:617374 inhibitor of CDK, cyclin A1 interacting protein 1 GO:0004861,GO:0005634,GO:0005654,GO:0005737,GO:0008285,GO:0016604,GO:0030332,GO:0032403,GO:0045736,GO:2001235 cyclin-dependent protein serine/threonine kinase inhibitor activity|nucleus|nucleoplasm|cytoplasm|negative regulation of cell proliferation|nuclear body|cyclin binding|protein complex binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of apoptotic signaling pathway INCENP 2110.59302668712 2024.28363631997 2196.90241705427 1.08527400885783 0.118059338810092 0.396183305319025 1 12.3248 12.0168 14.0974 12.3885 GeneID:3619,Genbank:NM_001040694.1,HGNC:HGNC:6058,MIM:604411 inner centromere protein GO:0000775,GO:0000776,GO:0000777,GO:0000800,GO:0000801,GO:0000910,GO:0005634,GO:0005654,GO:0005721,GO:0005819,GO:0005829,GO:0005874,GO:0007059,GO:0007062,GO:0010369,GO:0016604,GO:0016925,GO:0030496,GO:0043234 chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|lateral element|central element|cytokinesis|nucleus|nucleoplasm|pericentric heterochromatin|spindle|cytosol|microtubule|chromosome segregation|sister chromatid cohesion|chromocenter|nuclear body|protein sumoylation|midbody|protein complex INF2 939.439622144232 905.327903845204 973.551340443261 1.07535770885697 0.104816640235358 0.501620287476506 1 5.69106 5.40992 5.75256 6.20034 GeneID:64423,Genbank:NM_022489.3,HGNC:HGNC:23791,MIM:610982 inverted formin, FH2 and WH2 domain containing GO:0003779,GO:0017048,GO:0030036,GO:0048471,GO:0090140 actin binding|Rho GTPase binding|actin cytoskeleton organization|perinuclear region of cytoplasm|regulation of mitochondrial fission ING1 397.971769931563 405.32995668744 390.613583175687 0.963692854996401 -0.0533546861710787 0.764363757398874 1 4.8308 5.3431 5.21264 4.83482 GeneID:3621,Genbank:NM_198217.2,HGNC:HGNC:6062,MIM:601566 inhibitor of growth family member 1 GO:0005634,GO:0007049,GO:0008285,GO:0010941,GO:0030308,GO:0035064,GO:0046872 nucleus|cell cycle|negative regulation of cell proliferation|regulation of cell death|negative regulation of cell growth|methylated histone binding|metal ion binding ING2 152.417327337753 156.531639975682 148.303014699825 0.94743155264242 -0.0779063755934104 0.770369084693835 1 2.25646 2.30582 2.41704 1.9622 GeneID:3622,Genbank:NM_001564.3,HGNC:HGNC:6063,MIM:604215 inhibitor of growth family member 2 ING3 248.61152375164 256.350284494112 240.872763009168 0.939623544731043 -0.0898452305781911 0.696729255194527 1 3.31758 3.10982 3.25234 2.82545 GeneID:54556,Genbank:XM_017012369.2,HGNC:HGNC:14587,MIM:607493 inhibitor of growth family member 3 GO:0000812,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0032777,GO:0035064,GO:0035267,GO:0040008,GO:0043065,GO:0043967,GO:0043968,GO:0046872 Swr1 complex|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|Piccolo NuA4 histone acetyltransferase complex|methylated histone binding|NuA4 histone acetyltransferase complex|regulation of growth|positive regulation of apoptotic process|histone H4 acetylation|histone H2A acetylation|metal ion binding ING4 394.108361911145 390.406283564656 397.810440257635 1.01896526005006 0.0271048660200552 0.924317435742696 1 5.2567 4.74031 4.59204 6.75858 GeneID:51147,Genbank:NM_001127585.1,HGNC:HGNC:19423,MIM:608524 inhibitor of growth family member 4 ING5 701.554682830622 699.953836808911 703.155528852334 1.00457414742952 0.00658405305176392 0.990645418901887 1 2.3526 2.50696 2.46397 2.57728 GeneID:84289,Genbank:NM_001330161.1,HGNC:HGNC:19421,MIM:608525 inhibitor of growth family member 5 GO:0005634,GO:0005654,GO:0006260,GO:0006351,GO:0006473,GO:0008285,GO:0035064,GO:0043065,GO:0043966,GO:0045893,GO:0045926,GO:0046872,GO:0070776,GO:1901796 nucleus|nucleoplasm|DNA replication|transcription, DNA-templated|protein acetylation|negative regulation of cell proliferation|methylated histone binding|positive regulation of apoptotic process|histone H3 acetylation|positive regulation of transcription, DNA-templated|negative regulation of growth|metal ion binding|MOZ/MORF histone acetyltransferase complex|regulation of signal transduction by p53 class mediator INHA 3.72919410685856 4.06465003971372 3.3937381740034 0.834939820364564 -0.260255878127507 0.953453657300601 1 0.110114 0.0937864 0.134902 0.0630765 GeneID:3623,Genbank:NM_002191.3,HGNC:HGNC:6065,MIM:147380 inhibin alpha subunit hsa04060 Cytokine-cytokine receptor interaction INHBA 17.5396482183119 12.7800740704684 22.2992223661555 1.74484296751327 0.803097202518542 0.248976220076603 1 0.0403976 0.0679091 0.146291 0.0544018 GeneID:3624,Genbank:XM_017012175.1,HGNC:HGNC:6066,MIM:147290 inhibin beta A subunit hsa04060,hsa04350,hsa04550 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells INHBB 1.21223577044123 0 2.42447154088245 Inf Inf 0.339453305460821 1 0 0 0.0611541 0.0142585 GeneID:3625,Genbank:NM_002193.3,HGNC:HGNC:6067,MIM:147390 inhibin beta B subunit hsa04060,hsa04350,hsa04550 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells INHBE 10.5395239277776 13.8082431490681 7.27080470648717 0.526555379130753 -0.925342823853329 0.30916186971869 1 0.207555 0.233321 0.146238 0.0909697 GeneID:83729,Genbank:NM_031479.4,HGNC:HGNC:24029,MIM:612031 inhibin beta E subunit GO:0005125,GO:0005160,GO:0005179,GO:0005615,GO:0008083,GO:0010862,GO:0042981,GO:0043408,GO:0048468,GO:0060395 cytokine activity|transforming growth factor beta receptor binding|hormone activity|extracellular space|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of apoptotic process|regulation of MAPK cascade|cell development|SMAD protein signal transduction hsa04060,hsa04350,hsa04550 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells INIP 541.846430564993 544.757123869299 538.935737260686 0.989313794435096 -0.0154999016363808 0.933233699760274 1 5.25176 5.60798 5.8786 5.22477 GeneID:58493,Genbank:NM_001329589.1,HGNC:HGNC:24994,MIM:613273 INTS3 and NABP interacting protein GO:0005634,GO:0005654,GO:0006281,GO:0006974,GO:0010212,GO:0070876 nucleus|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|response to ionizing radiation|SOSS complex INMT 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.036081 0.0188019 0 GeneID:11185,Genbank:NM_006774.4,HGNC:HGNC:6069,MIM:604854 indolethylamine N-methyltransferase GO:0004790,GO:0005829,GO:0009308,GO:0009636,GO:0030748,GO:0032259,GO:0102707 thioether S-methyltransferase activity|cytosol|amine metabolic process|response to toxic substance|amine N-methyltransferase activity|methylation|S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity hsa00380,hsa00450 Tryptophan metabolism|Selenocompound metabolism INO80 1641.68145106373 1723.74068175543 1559.62222037203 0.904789355428877 -0.144346138327429 0.319025826476753 1 7.19972 6.91314 7.09302 5.84989 GeneID:54617,Genbank:NM_017553.2,HGNC:HGNC:26956,MIM:610169 INO80 complex subunit GO:0000070,GO:0000724,GO:0003677,GO:0003678,GO:0003779,GO:0005524,GO:0005634,GO:0005654,GO:0005874,GO:0005886,GO:0006302,GO:0006338,GO:0006351,GO:0010571,GO:0016579,GO:0016604,GO:0016887,GO:0030307,GO:0031011,GO:0034644,GO:0043014,GO:0045111,GO:0045944,GO:0051225,GO:0051301,GO:0070914,GO:0071479,GO:2000045 mitotic sister chromatid segregation|double-strand break repair via homologous recombination|DNA binding|DNA helicase activity|actin binding|ATP binding|nucleus|nucleoplasm|microtubule|plasma membrane|double-strand break repair|chromatin remodeling|transcription, DNA-templated|positive regulation of nuclear cell cycle DNA replication|protein deubiquitination|nuclear body|ATPase activity|positive regulation of cell growth|Ino80 complex|cellular response to UV|alpha-tubulin binding|intermediate filament cytoskeleton|positive regulation of transcription from RNA polymerase II promoter|spindle assembly|cell division|UV-damage excision repair|cellular response to ionizing radiation|regulation of G1/S transition of mitotic cell cycle INO80B 380.652868115909 380.403958772515 380.901777459302 1.00130865800764 0.00188676012506744 1 1 12.123 13.6741 13.1028 13.3368 GeneID:83444,Genbank:NM_031288.3,HGNC:HGNC:13324,MIM:616456 INO80 complex subunit B GO:0005634,GO:0005654,GO:0005730,GO:0006281,GO:0006310,GO:0006338,GO:0006351,GO:0006355,GO:0016579,GO:0031011,GO:0046872 nucleus|nucleoplasm|nucleolus|DNA repair|DNA recombination|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|protein deubiquitination|Ino80 complex|metal ion binding INO80C 156.804406230375 172.10806363384 141.50074882691 0.822162226680751 -0.282505004464718 0.255341063676472 1 2.56317 2.80015 2.18058 2.32441 GeneID:125476,Genbank:NM_194281.3,HGNC:HGNC:26994 INO80 complex subunit C GO:0001650,GO:0005654,GO:0006281,GO:0006310,GO:0006338,GO:0006351,GO:0006355,GO:0016579,GO:0031011,GO:0071339 fibrillar center|nucleoplasm|DNA repair|DNA recombination|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|protein deubiquitination|Ino80 complex|MLL1 complex INO80D 82.3367916179667 89.527145077325 75.1464381586085 0.839370428864946 -0.252620457111936 0.766287196582073 1 0.301661 0.151106 0.304115 0.112473 GeneID:54891,Genbank:NM_017759.4,HGNC:HGNC:25997 INO80 complex subunit D GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0006351,GO:0006355,GO:0016579 nucleus|nucleoplasm|DNA repair|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|protein deubiquitination INO80E 1325.77041378583 1341.67745468087 1309.86337289079 0.976287831565563 -0.0346215455077518 0.818589472917435 1 14.2222 14.9787 13.7373 15.4775 GeneID:283899,Genbank:XM_011545809.3,HGNC:HGNC:26905 INO80 complex subunit E GO:0005634,GO:0005654,GO:0005730,GO:0006281,GO:0006310,GO:0006338,GO:0006351,GO:0006355,GO:0016579,GO:0031011 nucleus|nucleoplasm|nucleolus|DNA repair|DNA recombination|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|protein deubiquitination|Ino80 complex INPP1 502.067169435216 529.218917830719 474.915421039713 0.897389350680062 -0.156194031234397 0.379612426929205 1 8.11501 7.54736 7.01453 7.23745 GeneID:3628,Genbank:NM_001128928.1,HGNC:HGNC:6071,MIM:147263 inositol polyphosphate-1-phosphatase GO:0004441,GO:0005829,GO:0006796,GO:0007165,GO:0043647,GO:0046854,GO:0046872,GO:0052829 inositol-1,4-bisphosphate 1-phosphatase activity|cytosol|phosphate-containing compound metabolic process|signal transduction|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|metal ion binding|inositol-1,3,4-trisphosphate 1-phosphatase activity hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP4A 604.230736617318 615.268553820512 593.192919414124 0.964120327181831 -0.0527148814245953 0.753608397052328 1 1.17078 1.22699 1.18834 1.13188 GeneID:3631,Genbank:XM_024452876.1,HGNC:HGNC:6074,MIM:600916 inositol polyphosphate-4-phosphatase type I A GO:0005737,GO:0005829,GO:0006661,GO:0007165,GO:0016316,GO:0017161,GO:0034597,GO:0043647,GO:0052828 cytoplasm|cytosol|phosphatidylinositol biosynthetic process|signal transduction|phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|inositol-1,3,4-trisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|inositol phosphate metabolic process|inositol-3,4-bisphosphate 4-phosphatase activity hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP4B 1.29177983152393 1.61429302992691 0.969266633120943 0.600427936658332 -0.735936990778882 0.974657200381333 1 0.0073144 0 0 0 GeneID:8821,Genbank:NM_001101669.2,HGNC:HGNC:6075,MIM:607494 inositol polyphosphate-4-phosphatase type II B GO:0005737,GO:0005829,GO:0006661,GO:0007165,GO:0016316,GO:0017161,GO:0034597,GO:0043647,GO:0052828 cytoplasm|cytosol|phosphatidylinositol biosynthetic process|signal transduction|phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|inositol-1,3,4-trisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|inositol phosphate metabolic process|inositol-3,4-bisphosphate 4-phosphatase activity hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5A 1090.63750379071 989.52209843079 1191.75290915063 1.20437220254155 0.26828131550149 0.0743796584293767 0.938990486715004 4.67216 4.6807 6.15024 5.45724 GeneID:3632,Genbank:NM_005539.4,HGNC:HGNC:6076,MIM:600106 inositol polyphosphate-5-phosphatase A GO:0004445,GO:0005622,GO:0005886,GO:0016020,GO:0042731,GO:0043647,GO:0046855,GO:0046856,GO:0048016,GO:0052658,GO:0052659,GO:0070062 inositol-polyphosphate 5-phosphatase activity|intracellular|plasma membrane|membrane|PH domain binding|inositol phosphate metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|inositol phosphate-mediated signaling|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|extracellular exosome hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5B 458.082630477242 491.65692466938 424.508336285104 0.863423893745764 -0.211859077474201 0.243982161743926 1 3.04125 2.81254 2.41049 2.70776 GeneID:3633,Genbank:NM_005540.2,HGNC:HGNC:6077,MIM:147264 inositol polyphosphate-5-phosphatase B GO:0001701,GO:0004439,GO:0005096,GO:0005793,GO:0005794,GO:0005829,GO:0005886,GO:0007165,GO:0007283,GO:0016020,GO:0016021,GO:0030317,GO:0030670,GO:0031901,GO:0043647,GO:0046856,GO:0046872,GO:0051056,GO:0052658,GO:0052659,GO:0070613 in utero embryonic development|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|GTPase activator activity|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|plasma membrane|signal transduction|spermatogenesis|membrane|integral component of membrane|flagellated sperm motility|phagocytic vesicle membrane|early endosome membrane|inositol phosphate metabolic process|phosphatidylinositol dephosphorylation|metal ion binding|regulation of small GTPase mediated signal transduction|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|regulation of protein processing hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5E 583.13449100212 606.99517491703 559.273807087211 0.921380976650529 -0.118130283330372 0.482326893519919 1 7.54596 6.97926 7.21289 6.56506 GeneID:56623,Genbank:NM_001318502.1,HGNC:HGNC:21474,MIM:613037 inositol polyphosphate-5-phosphatase E GO:0001726,GO:0004439,GO:0004445,GO:0005829,GO:0005886,GO:0005929,GO:0005930,GO:0006661,GO:0032580,GO:0046855,GO:0046856 ruffle|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|cytosol|plasma membrane|cilium|axoneme|phosphatidylinositol biosynthetic process|Golgi cisterna membrane|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5F 566.993084526804 544.61202804439 589.374141009218 1.08219082697377 0.113954917699362 0.582382009021689 1 2.51881 2.24104 2.97166 2.19224 GeneID:22876,Genbank:XM_011539524.3,HGNC:HGNC:17054,MIM:609389 inositol polyphosphate-5-phosphatase F GO:0001921,GO:0005769,GO:0005905,GO:0006661,GO:0008344,GO:0008934,GO:0014898,GO:0030424,GO:0030425,GO:0031161,GO:0031901,GO:0033137,GO:0034595,GO:0034596,GO:0042532,GO:0042803,GO:0043025,GO:0045334,GO:0046856,GO:0048015,GO:0048681,GO:0051896,GO:0052832,GO:0052833,GO:0055037,GO:0072583,GO:2000145,GO:2001135 positive regulation of receptor recycling|early endosome|clathrin-coated pit|phosphatidylinositol biosynthetic process|adult locomotory behavior|inositol monophosphate 1-phosphatase activity|cardiac muscle hypertrophy in response to stress|axon|dendrite|phosphatidylinositol catabolic process|early endosome membrane|negative regulation of peptidyl-serine phosphorylation|phosphatidylinositol phosphate 5-phosphatase activity|phosphatidylinositol phosphate 4-phosphatase activity|negative regulation of tyrosine phosphorylation of STAT protein|protein homodimerization activity|neuronal cell body|clathrin-coated endocytic vesicle|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|negative regulation of axon regeneration|regulation of protein kinase B signaling|inositol monophosphate 3-phosphatase activity|inositol monophosphate 4-phosphatase activity|recycling endosome|clathrin-dependent endocytosis|regulation of cell motility|regulation of endocytic recycling hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5J 75.4444366244406 74.3359486175015 76.5529246313797 1.0298237401299 0.0423974335242802 0.962316031515499 1 0.474121 0.636189 0.448416 0.728673 GeneID:27124,Genbank:XM_011530143.1,HGNC:HGNC:8956,MIM:606481 inositol polyphosphate-5-phosphatase J GO:0001726,GO:0004439,GO:0004445,GO:0005737,GO:0005829,GO:0005886,GO:0006661,GO:0010977,GO:0017124,GO:0030426,GO:0031115,GO:0033137,GO:0034485,GO:0043198,GO:0043647,GO:0046856,GO:0052658,GO:0052659 ruffle|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|cytoplasm|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|negative regulation of neuron projection development|SH3 domain binding|growth cone|negative regulation of microtubule polymerization|negative regulation of peptidyl-serine phosphorylation|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|dendritic shaft|inositol phosphate metabolic process|phosphatidylinositol dephosphorylation|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system INPP5K 977.121215987408 935.61627821719 1018.62615375763 1.08872213691986 0.12263579717829 0.436930423833623 1 8.79171 8.88206 9.4838 10.2624 GeneID:51763,Genbank:XM_005256683.2,HGNC:HGNC:33882,MIM:607875 inositol polyphosphate-5-phosphatase K GO:0001701,GO:0001726,GO:0001933,GO:0004439,GO:0004445,GO:0005000,GO:0005634,GO:0005737,GO:0005783,GO:0005802,GO:0005829,GO:0005886,GO:0005979,GO:0006469,GO:0006661,GO:0007186,GO:0010801,GO:0010829,GO:0016020,GO:0016311,GO:0016312,GO:0030036,GO:0032587,GO:0032869,GO:0032870,GO:0033137,GO:0034485,GO:0034594,GO:0034595,GO:0035305,GO:0035810,GO:0042577,GO:0042593,GO:0043005,GO:0043407,GO:0043922,GO:0045719,GO:0045869,GO:0045892,GO:0045893,GO:0046030,GO:0046627,GO:0046855,GO:0046856,GO:0048471,GO:0051497,GO:0051898,GO:0051926,GO:0052658,GO:0052659,GO:0071320,GO:0071356,GO:0071364,GO:0072659,GO:0090315,GO:0097178,GO:2000466,GO:2001153 in utero embryonic development|ruffle|negative regulation of protein phosphorylation|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|vasopressin receptor activity|nucleus|cytoplasm|endoplasmic reticulum|trans-Golgi network|cytosol|plasma membrane|regulation of glycogen biosynthetic process|negative regulation of protein kinase activity|phosphatidylinositol biosynthetic process|G-protein coupled receptor signaling pathway|negative regulation of peptidyl-threonine phosphorylation|negative regulation of glucose transport|membrane|dephosphorylation|inositol bisphosphate phosphatase activity|actin cytoskeleton organization|ruffle membrane|cellular response to insulin stimulus|cellular response to hormone stimulus|negative regulation of peptidyl-serine phosphorylation|phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|phosphatidylinositol trisphosphate phosphatase activity|phosphatidylinositol phosphate 5-phosphatase activity|negative regulation of dephosphorylation|positive regulation of urine volume|lipid phosphatase activity|glucose homeostasis|neuron projection|negative regulation of MAP kinase activity|negative regulation by host of viral transcription|negative regulation of glycogen biosynthetic process|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|inositol trisphosphate phosphatase activity|negative regulation of insulin receptor signaling pathway|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|negative regulation of stress fiber assembly|negative regulation of protein kinase B signaling|negative regulation of calcium ion transport|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|cellular response to cAMP|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|protein localization to plasma membrane|negative regulation of protein targeting to membrane|ruffle assembly|negative regulation of glycogen (starch) synthase activity|positive regulation of renal water transport hsa00562,hsa04070,hsa04910 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Insulin signaling pathway INPPL1 2883.39481466718 2762.68559054647 3004.1040387879 1.087385422745 0.120863392919004 0.390106050949639 1 17.2475 18.146 19.336 20.1086 GeneID:3636,Genbank:XM_024448503.1,HGNC:HGNC:6080,MIM:600829 inositol polyphosphate phosphatase like 1 hsa00562,hsa04070,hsa04662,hsa04666,hsa04910 Inositol phosphate metabolism|Phosphatidylinositol signaling system|B cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Insulin signaling pathway INSIG1 2497.5734722234 2210.95855484272 2784.18838960407 1.25926756225519 0.33258485154547 0.0156034341458944 0.520634586001344 31.1639 30.1572 39.2702 37.4555 GeneID:3638,Genbank:NM_001346591.1,HGNC:HGNC:6083,MIM:602055 insulin induced gene 1 GO:0005783,GO:0006641,GO:0006695,GO:0006991,GO:0008203,GO:0010894,GO:0016126,GO:0032933,GO:0032937,GO:0036315,GO:0036316,GO:0042472,GO:0042474,GO:0042632,GO:0045599,GO:0045717,GO:0060021,GO:0060363,GO:0070862,GO:1901303 endoplasmic reticulum|triglyceride metabolic process|cholesterol biosynthetic process|response to sterol depletion|cholesterol metabolic process|negative regulation of steroid biosynthetic process|sterol biosynthetic process|SREBP signaling pathway|SREBP-SCAP-Insig complex|cellular response to sterol|SREBP-SCAP complex retention in endoplasmic reticulum|inner ear morphogenesis|middle ear morphogenesis|cholesterol homeostasis|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|palate development|cranial suture morphogenesis|negative regulation of protein exit from endoplasmic reticulum|negative regulation of cargo loading into COPII-coated vesicle INSIG2 204.498238020763 206.910907826211 202.085568215316 0.976679143397565 -0.0340434060366154 0.979755639101843 1 4.36744 2.47452 3.3978 3.54633 GeneID:51141,Genbank:NM_016133.3,HGNC:HGNC:20452,MIM:608660 insulin induced gene 2 GO:0005789,GO:0006641,GO:0006695,GO:0008134,GO:0010894,GO:0032868,GO:0032933,GO:0032937,GO:0042472,GO:0042474,GO:0045717,GO:0060021,GO:0060363,GO:0070542 endoplasmic reticulum membrane|triglyceride metabolic process|cholesterol biosynthetic process|transcription factor binding|negative regulation of steroid biosynthetic process|response to insulin|SREBP signaling pathway|SREBP-SCAP-Insig complex|inner ear morphogenesis|middle ear morphogenesis|negative regulation of fatty acid biosynthetic process|palate development|cranial suture morphogenesis|response to fatty acid INSM1 2.43317278154274 1.96028560782945 2.90605995525603 1.48246762800743 0.568000601619137 0.909401689724841 1 0 0.105771 0.0287715 0.134291 GeneID:3642,Genbank:NM_002196.2,HGNC:HGNC:6090,MIM:600010 INSM transcriptional repressor 1 GO:0000122,GO:0000978,GO:0001047,GO:0001078,GO:0001933,GO:0003309,GO:0003310,GO:0003323,GO:0003358,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0007049,GO:0008285,GO:0010468,GO:0017053,GO:0030332,GO:0030335,GO:0031018,GO:0031490,GO:0042421,GO:0042826,GO:0043254,GO:0045597,GO:0046872,GO:0060290,GO:0061104,GO:0061549,GO:0071158,GO:2000179 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|core promoter binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|negative regulation of protein phosphorylation|type B pancreatic cell differentiation|pancreatic A cell differentiation|type B pancreatic cell development|noradrenergic neuron development|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|cell cycle|negative regulation of cell proliferation|regulation of gene expression|transcriptional repressor complex|cyclin binding|positive regulation of cell migration|endocrine pancreas development|chromatin DNA binding|norepinephrine biosynthetic process|histone deacetylase binding|regulation of protein complex assembly|positive regulation of cell differentiation|metal ion binding|transdifferentiation|adrenal chromaffin cell differentiation|sympathetic ganglion development|positive regulation of cell cycle arrest|positive regulation of neural precursor cell proliferation INSM2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0207523 0 GeneID:84684,Genbank:NM_032594.3,HGNC:HGNC:17539,MIM:614027 INSM transcriptional repressor 2 GO:0003677,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding INSR 380.157985701348 399.247186110104 361.068785292592 0.904374026553608 -0.145008536124314 0.436328981083627 1 1.48506 1.58322 1.48215 1.2574 GeneID:3643,Genbank:NM_001079817.2,HGNC:HGNC:6091,MIM:147670 insulin receptor hsa04010,hsa04014,hsa04015,hsa04022,hsa04066,hsa04068,hsa04072,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04520,hsa04910,hsa04913,hsa04923,hsa04930,hsa04931,hsa04932,hsa04960 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adherens junction|Insulin signaling pathway|Ovarian steroidogenesis|Regulation of lipolysis in adipocytes|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Aldosterone-regulated sodium reabsorption INTS1 4254.1037142802 3970.16195033188 4538.04547822852 1.14303787477716 0.192873208318705 0.156892157326766 1 20.3809 20.7649 24.8341 23.2583 GeneID:26173,Genbank:NM_001080453.2,HGNC:HGNC:24555,MIM:611345 integrator complex subunit 1 GO:0005654,GO:0016020,GO:0016021,GO:0016180,GO:0031965,GO:0032039,GO:0034474,GO:0042795 nucleoplasm|membrane|integral component of membrane|snRNA processing|nuclear membrane|integrator complex|U2 snRNA 3'-end processing|snRNA transcription from RNA polymerase II promoter INTS10 1389.14536054372 1388.34583972298 1389.94488136445 1.00115176031484 0.00166068272375742 0.983317333352547 1 12.0467 11.6414 12.2934 11.7287 GeneID:55174,Genbank:NM_001353511.1,HGNC:HGNC:25548,MIM:611353 integrator complex subunit 10 GO:0005634,GO:0005654,GO:0016180,GO:0032039,GO:0042795 nucleus|nucleoplasm|snRNA processing|integrator complex|snRNA transcription from RNA polymerase II promoter INTS11 1354.5090262972 1331.2320677606 1377.78598483379 1.03497054961387 0.0495897160042869 0.76290449534302 1 14.1631 16.4903 16.2009 15.9542 GeneID:54973,Genbank:NM_001256463.1,HGNC:HGNC:26052,MIM:611354 integrator complex subunit 11 GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0016180,GO:0016787,GO:0032039,GO:0042795,GO:0072562 nucleus|nucleoplasm|cytoplasm|cytosol|snRNA processing|hydrolase activity|integrator complex|snRNA transcription from RNA polymerase II promoter|blood microparticle INTS12 388.043171135627 375.791402401052 400.294939870202 1.06520515720314 0.0911313185028743 0.631766888752895 1 4.25475 4.48533 4.77064 4.80891 GeneID:57117,Genbank:NM_001142471.1,HGNC:HGNC:25067,MIM:611355 integrator complex subunit 12 GO:0005634,GO:0005654,GO:0016180,GO:0032039,GO:0042795,GO:0046872 nucleus|nucleoplasm|snRNA processing|integrator complex|snRNA transcription from RNA polymerase II promoter|metal ion binding INTS13 239.291864827565 254.668347879284 223.915381775846 0.879243076889887 -0.185666024690974 0.492634605398718 1 2.59349 1.9972 2.45539 1.8649 GeneID:55726,Genbank:XM_017019635.1,HGNC:HGNC:20174,MIM:615079 integrator complex subunit 13 GO:0005634,GO:0005654,GO:0005737,GO:0007052,GO:0007346,GO:0030317,GO:0042795,GO:0051301,GO:0051642,GO:0080154,GO:0090435 nucleus|nucleoplasm|cytoplasm|mitotic spindle organization|regulation of mitotic cell cycle|flagellated sperm motility|snRNA transcription from RNA polymerase II promoter|cell division|centrosome localization|regulation of fertilization|protein localization to nuclear envelope INTS14 1330.33375155528 1345.9125585074 1314.75494460317 0.976850194533603 -0.0337907611220607 0.825997900146247 1 17.9539 17.7697 16.8063 17.3288 GeneID:81556,Genbank:NM_001207059.1,HGNC:HGNC:25372 integrator complex subunit 14 GO:0005654,GO:0042795 nucleoplasm|snRNA transcription from RNA polymerase II promoter INTS2 195.106967082463 199.234478530019 190.979455634908 0.958566293565165 -0.0610498840785539 0.833941229139453 1 1.19776 1.29105 1.49607 0.884493 GeneID:57508,Genbank:NM_020748.3,HGNC:HGNC:29241,MIM:611346 integrator complex subunit 2 GO:0005622,GO:0005634,GO:0005654,GO:0005737,GO:0016020,GO:0016021,GO:0016180,GO:0031965,GO:0032039,GO:0034472,GO:0042795 intracellular|nucleus|nucleoplasm|cytoplasm|membrane|integral component of membrane|snRNA processing|nuclear membrane|integrator complex|snRNA 3'-end processing|snRNA transcription from RNA polymerase II promoter INTS3 1529.6105259161 1454.56229691616 1604.65875491604 1.10319012002312 0.141681441499084 0.324368290805348 1 9.84234 9.31535 11.4508 10.2028 GeneID:65123,Genbank:NM_023015.4,HGNC:HGNC:26153,MIM:611347 integrator complex subunit 3 GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006281,GO:0006974,GO:0007093,GO:0010212,GO:0016180,GO:0032039,GO:0042795,GO:0070876 nucleus|nucleoplasm|nucleolus|cytoplasm|DNA repair|cellular response to DNA damage stimulus|mitotic cell cycle checkpoint|response to ionizing radiation|snRNA processing|integrator complex|snRNA transcription from RNA polymerase II promoter|SOSS complex INTS4 408.288114103428 431.802604047391 384.773624159466 0.891086854393394 -0.166362036545653 0.365504731745143 1 3.93514 4.03068 3.40285 3.66795 GeneID:92105,Genbank:XM_017018560.2,HGNC:HGNC:25048,MIM:611348 integrator complex subunit 4 GO:0005634,GO:0005654,GO:0016180,GO:0032039,GO:0042795 nucleus|nucleoplasm|snRNA processing|integrator complex|snRNA transcription from RNA polymerase II promoter INTS5 605.356837485175 587.479579733852 623.234095236499 1.0608608651876 0.0852354552476062 0.628292776751406 1 9.9036 10.4179 11.3491 10.7119 GeneID:80789,Genbank:NM_030628.1,HGNC:HGNC:29352,MIM:611349 integrator complex subunit 5 GO:0005634,GO:0005654,GO:0005737,GO:0016020,GO:0016021,GO:0016180,GO:0031965,GO:0032039,GO:0042795 nucleus|nucleoplasm|cytoplasm|membrane|integral component of membrane|snRNA processing|nuclear membrane|integrator complex|snRNA transcription from RNA polymerase II promoter INTS6 365.265789161099 361.185312891701 369.346265430497 1.02259491803102 0.0322347614233691 0.897653908705808 1 1.29494 1.31007 1.54713 1.04332 GeneID:26512,Genbank:XM_011535040.3,HGNC:HGNC:14879,MIM:604331 integrator complex subunit 6 GO:0005634,GO:0005654,GO:0015629,GO:0016180,GO:0032039 nucleus|nucleoplasm|actin cytoskeleton|snRNA processing|integrator complex INTS6L 181.189047521416 201.463304475742 160.914790567091 0.798730026720409 -0.324220144836113 0.179512635029731 1 0.991948 0.885363 0.826323 0.539453 GeneID:203522,Genbank:NM_001351601.1,HGNC:HGNC:27334 integrator complex subunit 6 like INTS7 846.428239521361 913.005350142251 779.851128900471 0.854158334098443 -0.227424569953011 0.146723637234888 1 6.21679 6.21426 6.47133 4.70212 GeneID:25896,Genbank:XM_011509396.2,HGNC:HGNC:24484,MIM:611350 integrator complex subunit 7 GO:0000077,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0016180,GO:0016604,GO:0032039,GO:0034472,GO:0042795,GO:0071479 DNA damage checkpoint|nucleus|nucleoplasm|chromosome|cytoplasm|snRNA processing|nuclear body|integrator complex|snRNA 3'-end processing|snRNA transcription from RNA polymerase II promoter|cellular response to ionizing radiation INTS8 366.534325604057 377.808505937819 355.260145270294 0.940318017426436 -0.0887793332339116 0.670172251303675 1 1.77372 1.5594 1.74631 1.40793 GeneID:55656,Genbank:XM_017013616.1,HGNC:HGNC:26048,MIM:611351 integrator complex subunit 8 GO:0005654,GO:0016180,GO:0032039,GO:0042795 nucleoplasm|snRNA processing|integrator complex|snRNA transcription from RNA polymerase II promoter INTS9 508.070744802155 487.429595496251 528.711894108059 1.08469386962394 0.117287931985134 0.506848428478846 1 3.64742 3.93022 3.84434 4.26692 GeneID:55756,Genbank:NM_001145159.2,HGNC:HGNC:25592,MIM:611352 integrator complex subunit 9 GO:0005634,GO:0016180,GO:0032039 nucleus|snRNA processing|integrator complex INTU 47.1702993861453 46.8439238332043 47.4966749390864 1.01393459497984 0.0199645926355775 0.954685811755433 1 0.384837 0.178203 0.363468 0.294811 GeneID:27152,Genbank:XM_011531846.1,HGNC:HGNC:29239,MIM:610621 inturned planar cell polarity protein GO:0005737,GO:0007399,GO:0008589,GO:0009986,GO:0010839,GO:0021513,GO:0021915,GO:0030216,GO:0030278,GO:0031069,GO:0031514,GO:0036064,GO:0042733,GO:0044458,GO:0045880,GO:0051782,GO:0060173,GO:0060271,GO:1905515 cytoplasm|nervous system development|regulation of smoothened signaling pathway|cell surface|negative regulation of keratinocyte proliferation|spinal cord dorsal/ventral patterning|neural tube development|keratinocyte differentiation|regulation of ossification|hair follicle morphogenesis|motile cilium|ciliary basal body|embryonic digit morphogenesis|motile cilium assembly|positive regulation of smoothened signaling pathway|negative regulation of cell division|limb development|cilium assembly|non-motile cilium assembly INVS 176.065808436494 189.279163011709 162.85245386128 0.86038236470438 -0.216950140807793 0.375683733300944 1 1.1642 1.04066 1.02383 0.760498 GeneID:27130,Genbank:NM_001318381.1,HGNC:HGNC:17870,MIM:243305 inversin GO:0005516,GO:0005634,GO:0005737,GO:0005819,GO:0005874,GO:0005929,GO:0007275,GO:0016020,GO:0016055,GO:0090090 calmodulin binding|nucleus|cytoplasm|spindle|microtubule|cilium|multicellular organism development|membrane|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway hsa04310 Wnt signaling pathway IP6K1 2519.00687367477 2352.69403421203 2685.31971313752 1.14138076353685 0.190780153615127 0.170103955455676 1 22.1032 22.5573 26.6642 25.3749 GeneID:9807,Genbank:NM_001006115.2,HGNC:HGNC:18360,MIM:606991 inositol hexakisphosphate kinase 1 GO:0000827,GO:0000828,GO:0000829,GO:0000832,GO:0001650,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0032958,GO:0043647,GO:0046854,GO:0052723,GO:0052724,GO:0052836,GO:0052839 inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|fibrillar center|ATP binding|nucleus|nucleoplasm|cytosol|inositol phosphate biosynthetic process|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol 5-diphosphate pentakisphosphate 5-kinase activity|inositol diphosphate tetrakisphosphate kinase activity hsa04070 Phosphatidylinositol signaling system IP6K2 1568.8029132274 1495.64205078632 1641.96377566848 1.09783204798583 0.134657360288992 0.356497458021535 1 8.16739 8.7068 9.69966 8.68215 GeneID:51447,Genbank:NM_001005909.2,HGNC:HGNC:17313,MIM:606992 inositol hexakisphosphate kinase 2 GO:0000827,GO:0000828,GO:0000829,GO:0000832,GO:0001650,GO:0005524,GO:0005634,GO:0005654,GO:0006817,GO:0030054,GO:0030308,GO:0032958,GO:0043065,GO:0043647,GO:0046854,GO:0052723,GO:0052724,GO:0052836,GO:0052839,GO:0060337 inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|fibrillar center|ATP binding|nucleus|nucleoplasm|phosphate ion transport|cell junction|negative regulation of cell growth|inositol phosphate biosynthetic process|positive regulation of apoptotic process|inositol phosphate metabolic process|phosphatidylinositol phosphorylation|inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol 5-diphosphate pentakisphosphate 5-kinase activity|inositol diphosphate tetrakisphosphate kinase activity|type I interferon signaling pathway hsa04070 Phosphatidylinositol signaling system IP6K3 1.51280239516014 2.05633815719933 0.969266633120943 0.471355661872779 -1.08511203720016 0.811646606184739 1 0.0169689 0.00769408 0.0079816 0.00746604 GeneID:117283,Genbank:XM_024446324.1,HGNC:HGNC:17269,MIM:606993 inositol hexakisphosphate kinase 3 GO:0000827,GO:0000828,GO:0000829,GO:0000831,GO:0000832,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0032958,GO:0043647,GO:0046488,GO:0052723,GO:0052724,GO:0052836,GO:0052839 inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 6-kinase activity|inositol hexakisphosphate 5-kinase activity|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|inositol phosphate biosynthetic process|inositol phosphate metabolic process|phosphatidylinositol metabolic process|inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|inositol 5-diphosphate pentakisphosphate 5-kinase activity|inositol diphosphate tetrakisphosphate kinase activity hsa04070 Phosphatidylinositol signaling system IPCEF1 108.670269598333 102.960986684021 114.379552512645 1.11090186872107 0.151731382197561 0.595796293104452 1 0.529654 0.513317 0.626997 0.558714 GeneID:26034,Genbank:NM_015553.2,HGNC:HGNC:21204 interaction protein for cytohesin exchange factors 1 GO:0004601,GO:0005344,GO:0005737,GO:0005886,GO:0006979,GO:0015671 peroxidase activity|oxygen carrier activity|cytoplasm|plasma membrane|response to oxidative stress|oxygen transport IPMK 83.1715521598728 93.1595586448742 73.1835456748715 0.785572052287714 -0.348184490009615 0.304570541902905 1 0.871931 0.603614 0.605069 0.523702 GeneID:253430,Genbank:XM_017016013.2,HGNC:HGNC:20739,MIM:609851 inositol polyphosphate multikinase GO:0000823,GO:0000824,GO:0000825,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0008440,GO:0032958,GO:0043647,GO:0047326 inositol-1,4,5-trisphosphate 6-kinase activity|inositol tetrakisphosphate 3-kinase activity|inositol tetrakisphosphate 6-kinase activity|ATP binding|nucleus|nucleoplasm|nucleolus|inositol-1,4,5-trisphosphate 3-kinase activity|inositol phosphate biosynthetic process|inositol phosphate metabolic process|inositol tetrakisphosphate 5-kinase activity hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system IPO11 607.810652764838 614.13350653658 601.487798993096 0.979408862390852 -0.0300168442465598 0.913126847329089 1 4.8572 4.23466 5.1664 3.79687 GeneID:51194,Genbank:NM_016338.4,HGNC:HGNC:20628,MIM:610889 importin 11 GO:0001650,GO:0005634,GO:0005635,GO:0005829,GO:0006610,GO:0006886,GO:0008536,GO:0008565,GO:0042991 fibrillar center|nucleus|nuclear envelope|cytosol|ribosomal protein import into nucleus|intracellular protein transport|Ran GTPase binding|protein transporter activity|transcription factor import into nucleus IPO13 1439.33377363047 1315.78991427139 1562.87763298954 1.18778660334616 0.248275666148716 0.0929547012325075 0.987898138646211 11.4581 12.6873 14.6958 15.1576 GeneID:9670,Genbank:NM_014652.3,HGNC:HGNC:16853,MIM:610411 importin 13 GO:0005737,GO:0006606,GO:0006886,GO:0008139,GO:0008536,GO:0008565,GO:0031965 cytoplasm|protein import into nucleus|intracellular protein transport|nuclear localization sequence binding|Ran GTPase binding|protein transporter activity|nuclear membrane IPO4 1549.39713944594 1695.32838309872 1403.46589579315 0.827843095051529 -0.272570741947537 0.0566960915020313 0.865163284430535 17.9376 18.5898 15.2715 15.1953 GeneID:79711,Genbank:NM_024658.3,HGNC:HGNC:19426 importin 4 GO:0000060,GO:0000790,GO:0005737,GO:0006335,GO:0006336,GO:0006607,GO:0006610,GO:0008139,GO:0008536,GO:0008565,GO:0015031,GO:0016020,GO:0031965,GO:0034399,GO:0043234 protein import into nucleus, translocation|nuclear chromatin|cytoplasm|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|NLS-bearing protein import into nucleus|ribosomal protein import into nucleus|nuclear localization sequence binding|Ran GTPase binding|protein transporter activity|protein transport|membrane|nuclear membrane|nuclear periphery|protein complex IPO5 3645.45427117873 4042.74119974367 3248.16734261378 0.80345666025313 -0.315707890183296 0.0206116394900279 0.586657016555258 25.7239 24.333 22.2046 18.5255 GeneID:3843,Genbank:XM_011521089.2,HGNC:HGNC:6402,MIM:602008 importin 5 GO:0000060,GO:0003723,GO:0005095,GO:0005634,GO:0005643,GO:0005730,GO:0005737,GO:0006607,GO:0006610,GO:0008139,GO:0008536,GO:0008565,GO:0016020,GO:0016032,GO:0031965,GO:0034399,GO:0042307,GO:0045736,GO:0071230 protein import into nucleus, translocation|RNA binding|GTPase inhibitor activity|nucleus|nuclear pore|nucleolus|cytoplasm|NLS-bearing protein import into nucleus|ribosomal protein import into nucleus|nuclear localization sequence binding|Ran GTPase binding|protein transporter activity|membrane|viral process|nuclear membrane|nuclear periphery|positive regulation of protein import into nucleus|negative regulation of cyclin-dependent protein serine/threonine kinase activity|cellular response to amino acid stimulus IPO7 3007.24537260892 3439.31856946269 2575.17217575514 0.748744881797166 -0.417453858797069 0.0768517414654826 0.94157495521624 23.7916 20.8068 19.7585 13.9368 GeneID:10527,Genbank:NM_006391.2,HGNC:HGNC:9852,MIM:605586 importin 7 GO:0005215,GO:0005643,GO:0005654,GO:0005829,GO:0006606,GO:0006886,GO:0007165,GO:0008536,GO:0008565,GO:0016020,GO:0016032,GO:0030695,GO:0042393,GO:0045087,GO:0045736,GO:0046332 transporter activity|nuclear pore|nucleoplasm|cytosol|protein import into nucleus|intracellular protein transport|signal transduction|Ran GTPase binding|protein transporter activity|membrane|viral process|GTPase regulator activity|histone binding|innate immune response|negative regulation of cyclin-dependent protein serine/threonine kinase activity|SMAD binding IPO8 909.707080666046 960.088388348025 859.325772984068 0.895048605329626 -0.159962065288141 0.370207885011988 1 5.68423 5.12736 5.24125 4.2188 GeneID:10526,Genbank:NM_006390.3,HGNC:HGNC:9853,MIM:605600 importin 8 GO:0005635,GO:0005654,GO:0005829,GO:0006606,GO:0006886,GO:0007165,GO:0008536,GO:0008565,GO:0060964 nuclear envelope|nucleoplasm|cytosol|protein import into nucleus|intracellular protein transport|signal transduction|Ran GTPase binding|protein transporter activity|regulation of gene silencing by miRNA IPO9 4984.29121795815 4668.42978252255 5300.15265339376 1.1353180620251 0.183096528550585 0.168383131919143 1 13.8907 14.1881 17.3569 14.8301 GeneID:55705,Genbank:NM_018085.4,HGNC:HGNC:19425 importin 9 GO:0005635,GO:0005737,GO:0005829,GO:0006606,GO:0006886,GO:0008536,GO:0008565,GO:0016020,GO:0042393 nuclear envelope|cytoplasm|cytosol|protein import into nucleus|intracellular protein transport|Ran GTPase binding|protein transporter activity|membrane|histone binding IPP 270.593511013535 236.834689310934 304.352332716136 1.28508342085209 0.361862014627915 0.0805828229813515 0.951623427935096 2.03698 2.25542 2.85083 2.65786 GeneID:3652,Genbank:NM_001145349.1,HGNC:HGNC:6108,MIM:147485 intracisternal A particle-promoted polypeptide GO:0003779,GO:0005737,GO:0015629,GO:0016567,GO:0031463 actin binding|cytoplasm|actin cytoskeleton|protein ubiquitination|Cul3-RING ubiquitin ligase complex IPPK 349.520996484078 341.852014152155 357.189978816002 1.04486726428068 0.0633196797922725 0.74351521853133 1 2.90784 2.95712 3.46068 2.93774 GeneID:64768,Genbank:NM_022755.5,HGNC:HGNC:14645 inositol-pentakisphosphate 2-kinase GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0032947,GO:0032958,GO:0035299,GO:0043647,GO:0052746,GO:1901838 ATP binding|intracellular|nucleus|nucleoplasm|nucleolus|cytosol|protein complex scaffold activity|inositol phosphate biosynthetic process|inositol pentakisphosphate 2-kinase activity|inositol phosphate metabolic process|inositol phosphorylation|positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system IQCA1L 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0 0 GeneID:392843,Genbank:NM_001304419.1,HGNC:HGNC:22831 IQ motif containing with AAA domain 1 like GO:0005524 ATP binding IQCB1 228.088124659233 249.729416240133 206.446833078334 0.826682079294255 -0.274595482309684 0.224119624430823 1 2.69819 2.21708 1.9228 2.1728 GeneID:9657,Genbank:NM_001319107.1,HGNC:HGNC:28949,MIM:609237 IQ motif containing B1 GO:0001750,GO:0005516,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0015630,GO:0019899,GO:0032391,GO:0045171,GO:0045494,GO:0048496,GO:0060271,GO:0070062,GO:0072686,GO:0097711 photoreceptor outer segment|calmodulin binding|nucleoplasm|centrosome|centriole|cytosol|microtubule cytoskeleton|enzyme binding|photoreceptor connecting cilium|intercellular bridge|photoreceptor cell maintenance|maintenance of animal organ identity|cilium assembly|extracellular exosome|mitotic spindle|ciliary basal body-plasma membrane docking IQCC 170.371983353252 169.187252532311 171.556714174193 1.01400496554213 0.0200647171789843 0.979372009686357 1 1.42405 1.89847 1.65707 1.68998 GeneID:55721,Genbank:NM_001160042.1,HGNC:HGNC:25545 IQ motif containing C IQCD 25.4812468293755 22.8598511026174 28.1026425561336 1.22934495198509 0.297889790153524 0.594484460768804 1 0.206354 0.128696 0.152448 0.192468 GeneID:115811,Genbank:XM_011537864.2,HGNC:HGNC:25168 IQ motif containing D IQCE 859.175074037302 834.922335098469 883.427812976135 1.05809579626582 0.0814702498916007 0.610017816209313 1 3.64553 3.63322 3.71775 4.16809 GeneID:23288,Genbank:NM_152558.4,HGNC:HGNC:29171,MIM:617631 IQ motif containing E GO:0005929,GO:0060170 cilium|ciliary membrane IQCG 1776.61751677394 1817.90101751529 1735.33401603258 0.954581134678302 -0.0670602700989633 0.634596125752589 1 12.3468 13.0292 10.9437 12.7627 GeneID:84223,Genbank:NM_001323028.1,HGNC:HGNC:25251,MIM:612477 IQ motif containing G GO:0002177,GO:0005516,GO:0005737,GO:0007286,GO:0007288,GO:0030544,GO:0031514,GO:0036126,GO:0070062 manchette|calmodulin binding|cytoplasm|spermatid development|sperm axoneme assembly|Hsp70 protein binding|motile cilium|sperm flagellum|extracellular exosome IQCH 22.6588736571778 23.9938813856949 21.3238659286607 0.888720986233349 -0.170197538552518 0.798535039535616 1 0.0862225 0.101533 0.0893803 0.0593808 GeneID:64799,Genbank:XM_011521923.2,HGNC:HGNC:25721,MIM:612523 IQ motif containing H IQCK 61.9211603024421 64.726625677094 59.1156949277901 0.913313405563647 -0.130818085646465 0.744478303524373 1 0.48516 0.552884 0.505432 0.615639 GeneID:124152,Genbank:NM_153208.2,HGNC:HGNC:28556 IQ motif containing K IQCN 8.62888326607001 5.6309167949557 11.6268497371843 2.0648235732412 1.04601851729425 0.31092106476601 1 0.0418833 0.0432488 0.0463569 0.0940846 GeneID:80726,Genbank:NM_025249.3,HGNC:HGNC:29350 IQ motif containing N GO:0005634,GO:0005739 nucleus|mitochondrion IQGAP1 7377.24992658698 7076.37299428506 7678.12685888891 1.08503704724014 0.117744302538103 0.636749181222074 1 33.417 29.0769 40.8348 27.9214 GeneID:8826,Genbank:NM_003870.3,HGNC:HGNC:6110,MIM:603379 IQ motif containing GTPase activating protein 1 GO:0001726,GO:0001817,GO:0005095,GO:0005096,GO:0005509,GO:0005516,GO:0005547,GO:0005634,GO:0005737,GO:0005829,GO:0005874,GO:0005884,GO:0005886,GO:0005925,GO:0007165,GO:0007173,GO:0008543,GO:0016328,GO:0019901,GO:0019903,GO:0019904,GO:0030424,GO:0030426,GO:0030496,GO:0030667,GO:0031234,GO:0032403,GO:0035305,GO:0036057,GO:0036120,GO:0036464,GO:0043005,GO:0043234,GO:0043312,GO:0043406,GO:0043539,GO:0044548,GO:0045121,GO:0045296,GO:0045860,GO:0048008,GO:0048365,GO:0051019,GO:0051894,GO:0070062,GO:0071277,GO:0071364,GO:0072015,GO:1900006,GO:1900086,GO:1903829,GO:1904754,GO:1990138,GO:1990776 ruffle|regulation of cytokine production|GTPase inhibitor activity|GTPase activator activity|calcium ion binding|calmodulin binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|cytoplasm|cytosol|microtubule|actin filament|plasma membrane|focal adhesion|signal transduction|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|lateral plasma membrane|protein kinase binding|protein phosphatase binding|protein domain specific binding|axon|growth cone|midbody|secretory granule membrane|extrinsic component of cytoplasmic side of plasma membrane|protein complex binding|negative regulation of dephosphorylation|slit diaphragm|cellular response to platelet-derived growth factor stimulus|cytoplasmic ribonucleoprotein granule|neuron projection|protein complex|neutrophil degranulation|positive regulation of MAP kinase activity|protein serine/threonine kinase activator activity|S100 protein binding|membrane raft|cadherin binding|positive regulation of protein kinase activity|platelet-derived growth factor receptor signaling pathway|Rac GTPase binding|mitogen-activated protein kinase binding|positive regulation of focal adhesion assembly|extracellular exosome|cellular response to calcium ion|cellular response to epidermal growth factor stimulus|glomerular visceral epithelial cell development|positive regulation of dendrite development|positive regulation of peptidyl-tyrosine autophosphorylation|positive regulation of cellular protein localization|positive regulation of vascular associated smooth muscle cell migration|neuron projection extension|response to angiotensin hsa04520,hsa04810,hsa05205 Adherens junction|Regulation of actin cytoskeleton|Proteoglycans in cancer IQGAP2 83.4419740840385 76.7186620423875 90.1652861256894 1.1752718794271 0.23299453868707 0.62531229250588 1 0.345883 0.292028 0.519672 0.259305 GeneID:10788,Genbank:NM_006633.3,HGNC:HGNC:6111,MIM:605401 IQ motif containing GTPase activating protein 2 GO:0003779,GO:0005095,GO:0005516,GO:0005547,GO:0005737,GO:0005829,GO:0005874,GO:0005886,GO:0005902,GO:0007165,GO:0009986,GO:0015629,GO:0017048,GO:0030027,GO:0030175,GO:0030667,GO:0034314,GO:0043312,GO:0048365,GO:0051015,GO:0070062,GO:0070493,GO:0071933 actin binding|GTPase inhibitor activity|calmodulin binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|cytosol|microtubule|plasma membrane|microvillus|signal transduction|cell surface|actin cytoskeleton|Rho GTPase binding|lamellipodium|filopodium|secretory granule membrane|Arp2/3 complex-mediated actin nucleation|neutrophil degranulation|Rac GTPase binding|actin filament binding|extracellular exosome|thrombin-activated receptor signaling pathway|Arp2/3 complex binding hsa04810 Regulation of actin cytoskeleton IQGAP3 3028.94235734948 2810.42341328933 3247.46130140963 1.15550606575996 0.208524833166727 0.132018893485141 1 10.6447 11.7458 13.4073 12.858 GeneID:128239,Genbank:XM_024453275.1,HGNC:HGNC:20669 IQ motif containing GTPase activating protein 3 GO:0000082,GO:0000187,GO:0005516,GO:0005829,GO:0005911,GO:0007265,GO:0008361,GO:0010628,GO:0010629,GO:0016328,GO:0017048,GO:0033601,GO:0043087,GO:0070371,GO:0070856,GO:0071310 G1/S transition of mitotic cell cycle|activation of MAPK activity|calmodulin binding|cytosol|cell-cell junction|Ras protein signal transduction|regulation of cell size|positive regulation of gene expression|negative regulation of gene expression|lateral plasma membrane|Rho GTPase binding|positive regulation of mammary gland epithelial cell proliferation|regulation of GTPase activity|ERK1 and ERK2 cascade|myosin VI light chain binding|cellular response to organic substance hsa04810 Regulation of actin cytoskeleton IQSEC1 497.580785327543 540.09654122315 455.065029431936 0.842562384127392 -0.247144586113049 0.159468175453722 1 2.34337 2.10775 1.90429 1.84552 GeneID:9922,Genbank:NM_001134382.2,HGNC:HGNC:29112,MIM:610166 IQ motif and Sec7 domain 1 GO:0005086,GO:0005730,GO:0005737,GO:0008289,GO:0016020,GO:0030036,GO:0032012,GO:0043231,GO:0043547 ARF guanyl-nucleotide exchange factor activity|nucleolus|cytoplasm|lipid binding|membrane|actin cytoskeleton organization|regulation of ARF protein signal transduction|intracellular membrane-bounded organelle|positive regulation of GTPase activity hsa04144 Endocytosis IQSEC2 241.225819149369 259.522052625027 222.92958567371 0.85900054896611 -0.219269041532434 0.294528187087332 1 0.546105 0.633312 0.491904 0.503774 GeneID:23096,Genbank:XM_006724582.4,HGNC:HGNC:29059,MIM:300522 IQ motif and Sec7 domain 2 GO:0005086,GO:0005737,GO:0030036,GO:0032012 ARF guanyl-nucleotide exchange factor activity|cytoplasm|actin cytoskeleton organization|regulation of ARF protein signal transduction hsa04144 Endocytosis IQUB 1.29221481755063 1.61429302992691 0.97013660517434 0.600966854957097 -0.734642670519382 0.974659005890232 1 0.0151108 0 0.00976755 0 GeneID:154865,Genbank:NM_178827.4,HGNC:HGNC:21995 IQ motif and ubiquitin domain containing GO:0001669,GO:0007224,GO:0031514,GO:0060271 acrosomal vesicle|smoothened signaling pathway|motile cilium|cilium assembly IRAK1 18166.7132444139 17034.0614024176 19299.3650864101 1.13298670413804 0.180130930896589 0.169637010965172 1 187.18 192.617 224.979 214.688 GeneID:3654,Genbank:NM_001025243.1,HGNC:HGNC:6112,MIM:300283 interleukin 1 receptor associated kinase 1 GO:0000187,GO:0001959,GO:0002224,GO:0002755,GO:0004672,GO:0004674,GO:0004704,GO:0005524,GO:0005634,GO:0005737,GO:0005811,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0007178,GO:0007250,GO:0007254,GO:0007568,GO:0010008,GO:0016032,GO:0016301,GO:0031072,GO:0031663,GO:0032088,GO:0032481,GO:0032496,GO:0034134,GO:0034142,GO:0034162,GO:0034605,GO:0042803,GO:0043066,GO:0043123,GO:0043406,GO:0045323,GO:0045893,GO:0046777,GO:0046982,GO:0048661,GO:0051092,GO:0051259,GO:0060337,GO:0070423,GO:0070498,GO:0070555,GO:0071456 activation of MAPK activity|regulation of cytokine-mediated signaling pathway|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|NF-kappaB-inducing kinase activity|ATP binding|nucleus|cytoplasm|lipid droplet|cytosol|plasma membrane|protein phosphorylation|signal transduction|transmembrane receptor protein serine/threonine kinase signaling pathway|activation of NF-kappaB-inducing kinase activity|JNK cascade|aging|endosome membrane|viral process|kinase activity|heat shock protein binding|lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|positive regulation of type I interferon production|response to lipopolysaccharide|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 9 signaling pathway|cellular response to heat|protein homodimerization activity|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAP kinase activity|interleukin-1 receptor complex|positive regulation of transcription, DNA-templated|protein autophosphorylation|protein heterodimerization activity|positive regulation of smooth muscle cell proliferation|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|type I interferon signaling pathway|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|response to interleukin-1|cellular response to hypoxia hsa04010,hsa04064,hsa04620,hsa04722,hsa05133,hsa05140,hsa05142,hsa05145,hsa05152,hsa05162,hsa05169,hsa05170 MAPK signaling pathway|NF-kappa B signaling pathway|Toll-like receptor signaling pathway|Neurotrophin signaling pathway|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Measles|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection IRAK1BP1 56.2651886668477 61.1618556944456 51.3685216392498 0.839878402249243 -0.251747625532477 0.506783899328011 1 0.497069 0.743306 0.442316 0.526474 GeneID:134728,Genbank:XM_011535448.2,HGNC:HGNC:17368,MIM:615375 interleukin 1 receptor associated kinase 1 binding protein 1 GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0006955,GO:0007249 nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|immune response|I-kappaB kinase/NF-kappaB signaling IRAK2 411.424655533384 401.687734464783 421.161576601984 1.0484800517077 0.0682994131024589 0.714082824745556 1 4.79812 4.75698 5.44262 4.65648 GeneID:3656,Genbank:NM_001570.3,HGNC:HGNC:6113,MIM:603304 interleukin 1 receptor associated kinase 2 GO:0000187,GO:0001959,GO:0002224,GO:0002755,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006954,GO:0007249,GO:0007254,GO:0010008,GO:0031663,GO:0032088,GO:0034162,GO:0035556,GO:0042803,GO:0046982,GO:0051092,GO:0070423,GO:0070498,GO:0070555 activation of MAPK activity|regulation of cytokine-mediated signaling pathway|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein phosphorylation|inflammatory response|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|toll-like receptor 9 signaling pathway|intracellular signal transduction|protein homodimerization activity|protein heterodimerization activity|positive regulation of NF-kappaB transcription factor activity|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|response to interleukin-1 hsa04722,hsa05152 Neurotrophin signaling pathway|Tuberculosis IRAK4 273.129941081264 278.739681504987 267.52020065754 0.959749251391585 -0.0592705651228423 0.785150519605564 1 1.50524 1.44879 1.48531 1.40513 GeneID:51135,Genbank:XM_017019390.2,HGNC:HGNC:17967,MIM:606883 interleukin 1 receptor associated kinase 4 hsa04010,hsa04064,hsa04620,hsa04621,hsa04722,hsa05133,hsa05140,hsa05142,hsa05145,hsa05152,hsa05162,hsa05164,hsa05169,hsa05170 MAPK signaling pathway|NF-kappa B signaling pathway|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Neurotrophin signaling pathway|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Measles|Influenza A|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection IREB2 777.953860889222 841.445116801368 714.462604977077 0.849089965240993 -0.236010672403843 0.413625961826811 1 4.81545 4.2395 4.66378 3.11013 GeneID:3658,Genbank:NM_001354994.1,HGNC:HGNC:6115,MIM:147582 iron responsive element binding protein 2 GO:0003723,GO:0005737,GO:0005829,GO:0006826,GO:0006879,GO:0008152,GO:0030350,GO:0030371,GO:0046872,GO:0051539 RNA binding|cytoplasm|cytosol|iron ion transport|cellular iron ion homeostasis|metabolic process|iron-responsive element binding|translation repressor activity|metal ion binding|4 iron, 4 sulfur cluster binding IRF1 713.429307179792 677.054751085862 749.803863273722 1.10744937846043 0.14724075466002 0.399483951007576 1 6.62431 6.54595 8.47008 6.25157 GeneID:3659,Genbank:NM_001354924.1,HGNC:HGNC:6116,MIM:147575 interferon regulatory factor 1 hsa04625,hsa04668,hsa04917,hsa05133,hsa05160,hsa05165 C-type lectin receptor signaling pathway|TNF signaling pathway|Prolactin signaling pathway|Pertussis|Hepatitis C|Human papillomavirus infection IRF2 222.271536858655 233.692347145342 210.850726571968 0.902257729650136 -0.148388497130439 0.5808834935143 1 0.889864 0.861149 0.983654 0.585162 GeneID:3660,Genbank:XM_024454039.1,HGNC:HGNC:6117,MIM:147576 interferon regulatory factor 2 GO:0000122,GO:0000977,GO:0001228,GO:0003677,GO:0003700,GO:0005654,GO:0005829,GO:0005925,GO:0006355,GO:0007596,GO:0008283,GO:0045944,GO:0051607,GO:0060333,GO:0060337 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleoplasm|cytosol|focal adhesion|regulation of transcription, DNA-templated|blood coagulation|cell proliferation|positive regulation of transcription from RNA polymerase II promoter|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway IRF2BP1 1039.90325339127 996.71150732759 1083.09499945494 1.08666850085735 0.11991189886609 0.457492987725139 1 24.3978 26.0571 27.317 28.9252 GeneID:26145,Genbank:NM_015649.2,HGNC:HGNC:21728,MIM:615331 interferon regulatory factor 2 binding protein 1 GO:0005654,GO:0006351,GO:0006355,GO:0016740,GO:0046872 nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|transferase activity|metal ion binding IRF2BP2 2256.34679784308 2228.07385329251 2284.61974239364 1.02537882171974 0.0361570055829436 0.803188844587914 1 24.744 25.8404 27.9646 24.4466 GeneID:359948,Genbank:NM_001077397.1,HGNC:HGNC:21729,MIM:615332 interferon regulatory factor 2 binding protein 2 GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006355,GO:0046872 nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding IRF2BPL 2661.29452456028 2476.96923955449 2845.61980956606 1.14883130727852 0.200166970290337 0.151614347596076 1 34.3049 34.7104 39.5145 41.6026 GeneID:64207,Genbank:NM_024496.3,HGNC:HGNC:14282,MIM:611720 interferon regulatory factor 2 binding protein like GO:0000122,GO:0005615,GO:0005634,GO:0005654,GO:0045944,GO:0046543,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|extracellular space|nucleus|nucleoplasm|positive regulation of transcription from RNA polymerase II promoter|development of secondary female sexual characteristics|metal ion binding IRF3 1152.76441796728 1166.68578056422 1138.84305537033 0.97613519796185 -0.0348471152129522 0.799807138757244 1 14.1711 15.9399 16.1667 16.0406 GeneID:3661,Genbank:NM_001197128.1,HGNC:HGNC:6118,MIM:603734 interferon regulatory factor 3 GO:0000978,GO:0001077,GO:0001078,GO:0001228,GO:0003677,GO:0003712,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006366,GO:0006915,GO:0006974,GO:0016032,GO:0019904,GO:0031663,GO:0032479,GO:0032480,GO:0032481,GO:0032727,GO:0032728,GO:0035666,GO:0039530,GO:0042802,GO:0042803,GO:0043123,GO:0043330,GO:0043565,GO:0045351,GO:0045944,GO:0050715,GO:0051607,GO:0060333,GO:0060337,GO:0060340,GO:0071359,GO:0071888,GO:0097300 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|transcription cofactor activity|nucleus|nucleoplasm|cytoplasm|cytosol|transcription from RNA polymerase II promoter|apoptotic process|cellular response to DNA damage stimulus|viral process|protein domain specific binding|lipopolysaccharide-mediated signaling pathway|regulation of type I interferon production|negative regulation of type I interferon production|positive regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|TRIF-dependent toll-like receptor signaling pathway|MDA-5 signaling pathway|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|sequence-specific DNA binding|type I interferon biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of cytokine secretion|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|positive regulation of type I interferon-mediated signaling pathway|cellular response to dsRNA|macrophage apoptotic process|programmed necrotic cell death hsa04620,hsa04621,hsa04622,hsa04623,hsa05133,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170,hsa05203 Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Pertussis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis IRF4 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0.00839812 0 0.00794878 0.00742547 GeneID:3662,Genbank:NM_002460.3,HGNC:HGNC:6119,MIM:601900 interferon regulatory factor 4 hsa04659 Th17 cell differentiation IRF5 223.123394596977 212.668320136715 233.578469057239 1.09832281981201 0.13530215460837 0.569786019480568 1 1.96326 2.40908 2.22774 2.33293 GeneID:3663,Genbank:NM_001347928.1,HGNC:HGNC:6120,MIM:607218 interferon regulatory factor 5 GO:0001228,GO:0005634,GO:0005737,GO:0005829,GO:0032494,GO:0032495,GO:0032727,GO:0032728,GO:0032735,GO:0042802,GO:0043065,GO:0043565,GO:0044212,GO:0045944,GO:0051607,GO:0060333,GO:0060337 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|cytoplasm|cytosol|response to peptidoglycan|response to muramyl dipeptide|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|identical protein binding|positive regulation of apoptotic process|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway hsa04620 Toll-like receptor signaling pathway IRF6 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00971887 0 0 0 GeneID:3664,Genbank:NM_001206696.1,HGNC:HGNC:6121,MIM:607199 interferon regulatory factor 6 GO:0001228,GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0005829,GO:0007050,GO:0008285,GO:0030054,GO:0030216,GO:0043565,GO:0043616,GO:0044212,GO:0045893,GO:0045944,GO:0048468,GO:0060333,GO:0060337,GO:0060644,GO:0070062 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|cytosol|cell cycle arrest|negative regulation of cell proliferation|cell junction|keratinocyte differentiation|sequence-specific DNA binding|keratinocyte proliferation|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|cell development|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|mammary gland epithelial cell differentiation|extracellular exosome IRF7 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0248858 0 GeneID:3665,Genbank:XM_011520066.3,HGNC:HGNC:6122,MIM:605047 interferon regulatory factor 7 GO:0000122,GO:0000979,GO:0000982,GO:0002819,GO:0003677,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006366,GO:0006974,GO:0009615,GO:0010008,GO:0016064,GO:0019043,GO:0032479,GO:0032481,GO:0032607,GO:0032608,GO:0032727,GO:0032728,GO:0034124,GO:0034127,GO:0035666,GO:0039530,GO:0045087,GO:0045351,GO:0045655,GO:0045893,GO:0045944,GO:0050776,GO:0051607,GO:0060333,GO:0060337,GO:0060340,GO:2000110 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II core promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|regulation of adaptive immune response|DNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription from RNA polymerase II promoter|cellular response to DNA damage stimulus|response to virus|endosome membrane|immunoglobulin mediated immune response|establishment of viral latency|regulation of type I interferon production|positive regulation of type I interferon production|interferon-alpha production|interferon-beta production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of MyD88-dependent toll-like receptor signaling pathway|regulation of MyD88-independent toll-like receptor signaling pathway|TRIF-dependent toll-like receptor signaling pathway|MDA-5 signaling pathway|innate immune response|type I interferon biosynthetic process|regulation of monocyte differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of immune response|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|positive regulation of type I interferon-mediated signaling pathway|negative regulation of macrophage apoptotic process hsa04620,hsa04621,hsa04622,hsa04623,hsa05160,hsa05161,hsa05162,hsa05164,hsa05167,hsa05168,hsa05169,hsa05203 Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Viral carcinogenesis IRF9 1100.84335098907 895.161882918793 1306.52481905936 1.45954027309481 0.54551401967372 0.40674462163128 1 20.4247 21.3977 43.4244 17.7385 GeneID:10379,Genbank:NM_006084.4,HGNC:HGNC:6131,MIM:147574 interferon regulatory factor 9 GO:0001047,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006366,GO:0007166,GO:0051607,GO:0060333,GO:0060337 core promoter binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|transcription from RNA polymerase II promoter|cell surface receptor signaling pathway|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway hsa04217,hsa04380,hsa04621,hsa04625,hsa04630,hsa05160,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05203 Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Viral carcinogenesis IRGC 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0313325 0 GeneID:56269,Genbank:NM_019612.3,HGNC:HGNC:28835 immunity related GTPase cinema GO:0003924,GO:0005525,GO:0016020 GTPase activity|GTP binding|membrane IRGM 1.07619535328461 2.15239070656922 0 0 -Inf 0.475634333897108 1 0 0 0 0 GeneID:345611,Genbank:NM_001346557.1,HGNC:HGNC:29597,MIM:608212 immunity related GTPase M GO:0000045,GO:0000139,GO:0000421,GO:0001891,GO:0001934,GO:0005525,GO:0005739,GO:0005794,GO:0005829,GO:0006954,GO:0010508,GO:0010800,GO:0016787,GO:0019901,GO:0030670,GO:0031648,GO:0033138,GO:0042742,GO:0042995,GO:0043254,GO:0043539,GO:0045087,GO:0050700,GO:0050821,GO:0050829,GO:0051434,GO:0060335,GO:0061635,GO:0061739,GO:0061762,GO:0070431,GO:0071222,GO:0071902,GO:0075044,GO:0098586,GO:1901098 autophagosome assembly|Golgi membrane|autophagosome membrane|phagocytic cup|positive regulation of protein phosphorylation|GTP binding|mitochondrion|Golgi apparatus|cytosol|inflammatory response|positive regulation of autophagy|positive regulation of peptidyl-threonine phosphorylation|hydrolase activity|protein kinase binding|phagocytic vesicle membrane|protein destabilization|positive regulation of peptidyl-serine phosphorylation|defense response to bacterium|cell projection|regulation of protein complex assembly|protein serine/threonine kinase activator activity|innate immune response|CARD domain binding|protein stabilization|defense response to Gram-negative bacterium|BH3 domain binding|positive regulation of interferon-gamma-mediated signaling pathway|regulation of protein complex stability|protein lipidation involved in autophagosome assembly|CAMKK-AMPK signaling cascade|nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to lipopolysaccharide|positive regulation of protein serine/threonine kinase activity|autophagy of host cells involved in interaction with symbiont|cellular response to virus|positive regulation of autophagosome maturation hsa05145 Toxoplasmosis IRGQ 959.32248093853 1032.30238922514 886.342572651925 0.858607499026743 -0.219929321634065 0.149102595953147 1 4.69652 4.9185 4.07512 4.32019 GeneID:126298,Genbank:NM_001007561.2,HGNC:HGNC:24868 immunity related GTPase Q GO:0005525 GTP binding IRS1 1592.26831548172 1668.04808072338 1516.48855024007 0.909139591217547 -0.137426269009476 0.33269293135559 1 7.88355 8.49992 8.26576 6.86185 GeneID:3667,Genbank:NM_005544.2,HGNC:HGNC:6125,MIM:147545 insulin receptor substrate 1 GO:0000165,GO:0001784,GO:0004871,GO:0005068,GO:0005080,GO:0005088,GO:0005158,GO:0005159,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005899,GO:0005901,GO:0007165,GO:0008284,GO:0008286,GO:0010907,GO:0014065,GO:0016303,GO:0032000,GO:0032868,GO:0032869,GO:0038111,GO:0042169,GO:0042593,GO:0043231,GO:0043434,GO:0043548,GO:0043552,GO:0045725,GO:0046326,GO:0046627,GO:0046628,GO:0046676,GO:0046934,GO:0048009,GO:0048015,GO:0051897,GO:2001275 MAPK cascade|phosphotyrosine residue binding|signal transducer activity|transmembrane receptor protein tyrosine kinase adaptor activity|protein kinase C binding|Ras guanyl-nucleotide exchange factor activity|insulin receptor binding|insulin-like growth factor receptor binding|nucleus|cytoplasm|cytosol|plasma membrane|insulin receptor complex|caveola|signal transduction|positive regulation of cell proliferation|insulin receptor signaling pathway|positive regulation of glucose metabolic process|phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-3-kinase activity|positive regulation of fatty acid beta-oxidation|response to insulin|cellular response to insulin stimulus|interleukin-7-mediated signaling pathway|SH2 domain binding|glucose homeostasis|intracellular membrane-bounded organelle|response to peptide hormone|phosphatidylinositol 3-kinase binding|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|negative regulation of insulin receptor signaling pathway|positive regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|insulin-like growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein kinase B signaling|positive regulation of glucose import in response to insulin stimulus hsa04022,hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04722,hsa04910,hsa04920,hsa04923,hsa04930,hsa04931,hsa04932,hsa04960,hsa05206 cGMP-PKG signaling pathway|FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Neurotrophin signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Regulation of lipolysis in adipocytes|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Aldosterone-regulated sodium reabsorption|MicroRNAs in cancer IRS2 1905.61637458557 1732.58260130173 2078.65014786941 1.19974086448038 0.262722827582946 0.0648747362935177 0.901211712368954 14.6501 14.7408 19.2603 16.8023 GeneID:8660,Genbank:NM_003749.2,HGNC:HGNC:6126,MIM:600797 insulin receptor substrate 2 GO:0000165,GO:0002053,GO:0002903,GO:0004871,GO:0005088,GO:0005158,GO:0005829,GO:0005886,GO:0006006,GO:0007165,GO:0007411,GO:0007420,GO:0008283,GO:0008284,GO:0008286,GO:0009749,GO:0010748,GO:0010907,GO:0016303,GO:0019216,GO:0019901,GO:0019903,GO:0019904,GO:0030335,GO:0030879,GO:0030890,GO:0032000,GO:0032024,GO:0032869,GO:0033673,GO:0038111,GO:0043234,GO:0043548,GO:0045725,GO:0046326,GO:0046934,GO:0048015,GO:0051897,GO:0055088,GO:0071333,GO:0071889 MAPK cascade|positive regulation of mesenchymal cell proliferation|negative regulation of B cell apoptotic process|signal transducer activity|Ras guanyl-nucleotide exchange factor activity|insulin receptor binding|cytosol|plasma membrane|glucose metabolic process|signal transduction|axon guidance|brain development|cell proliferation|positive regulation of cell proliferation|insulin receptor signaling pathway|response to glucose|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of glucose metabolic process|1-phosphatidylinositol-3-kinase activity|regulation of lipid metabolic process|protein kinase binding|protein phosphatase binding|protein domain specific binding|positive regulation of cell migration|mammary gland development|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of insulin secretion|cellular response to insulin stimulus|negative regulation of kinase activity|interleukin-7-mediated signaling pathway|protein complex|phosphatidylinositol 3-kinase binding|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase B signaling|lipid homeostasis|cellular response to glucose stimulus|14-3-3 protein binding hsa04022,hsa04068,hsa04140,hsa04152,hsa04211,hsa04213,hsa04910,hsa04920,hsa04923,hsa04930,hsa04931,hsa04932,hsa05206 cGMP-PKG signaling pathway|FoxO signaling pathway|Autophagy - animal|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Insulin signaling pathway|Adipocytokine signaling pathway|Regulation of lipolysis in adipocytes|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|MicroRNAs in cancer IRS4 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.00481622 0 0 GeneID:8471,Genbank:XM_005262220.2,HGNC:HGNC:6128,MIM:300904 insulin receptor substrate 4 GO:0004871,GO:0005070,GO:0005158,GO:0005829,GO:0005886,GO:0007165,GO:0008286,GO:0019216,GO:0043548 signal transducer activity|SH3/SH2 adaptor activity|insulin receptor binding|cytosol|plasma membrane|signal transduction|insulin receptor signaling pathway|regulation of lipid metabolic process|phosphatidylinositol 3-kinase binding hsa04022,hsa04068,hsa04140,hsa04152,hsa04211,hsa04213,hsa04910,hsa04920,hsa04923,hsa04930 cGMP-PKG signaling pathway|FoxO signaling pathway|Autophagy - animal|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Insulin signaling pathway|Adipocytokine signaling pathway|Regulation of lipolysis in adipocytes|Type II diabetes mellitus IRX1 1500.96282205124 1496.24779204786 1505.67785205461 1.00630247212852 0.00906401235113192 0.966552085847607 1 36.6993 36.5926 36.6531 38.368 GeneID:79192,Genbank:XM_017009845.1,HGNC:HGNC:14358,MIM:606197 iroquois homeobox 1 GO:0000122,GO:0001227,GO:0005634,GO:0043565,GO:0072086,GO:0072272 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|sequence-specific DNA binding|specification of loop of Henle identity|proximal/distal pattern formation involved in metanephric nephron development IRX3 222.224448412504 214.234586891957 230.214309933052 1.07458983758376 0.10378609962813 0.672122734860538 1 3.10674 3.63037 4.12051 3.25261 GeneID:79191,Genbank:NM_024336.2,HGNC:HGNC:14360,MIM:612985 iroquois homeobox 3 GO:0001656,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0007498,GO:0030424,GO:0043565,GO:0045665,GO:0045666,GO:0072086 metanephros development|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|mesoderm development|axon|sequence-specific DNA binding|negative regulation of neuron differentiation|positive regulation of neuron differentiation|specification of loop of Henle identity IRX5 18.0093091639366 20.025283895351 15.9933344325223 0.798657063545311 -0.324351939579661 0.657970381661481 1 0.363528 0.321229 0.3008 0.26411 GeneID:10265,Genbank:NM_005853.5,HGNC:HGNC:14361,MIM:606195 iroquois homeobox 5 GO:0002027,GO:0005499,GO:0005634,GO:0006351,GO:0006355,GO:0007601,GO:0008406,GO:0042551,GO:0043565,GO:0048701,GO:0050896,GO:0060040 regulation of heart rate|vitamin D binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|visual perception|gonad development|neuron maturation|sequence-specific DNA binding|embryonic cranial skeleton morphogenesis|response to stimulus|retinal bipolar neuron differentiation IRX6 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0140359 0 0 GeneID:79190,Genbank:XM_005256137.3,HGNC:HGNC:14675,MIM:606196 iroquois homeobox 6 GO:0005634,GO:0006355,GO:0043565 nucleus|regulation of transcription, DNA-templated|sequence-specific DNA binding ISCA1 606.197042465831 548.485589986218 663.908494945443 1.2104392659835 0.275530693659379 0.100557968568408 1 11.7521 12.7392 14.2966 15.1789 GeneID:81689,Genbank:NM_030940.3,HGNC:HGNC:28660,MIM:611006 iron-sulfur cluster assembly 1 GO:0005198,GO:0005759,GO:0008198,GO:0016226,GO:0044281,GO:0051537,GO:0097428 structural molecule activity|mitochondrial matrix|ferrous iron binding|iron-sulfur cluster assembly|small molecule metabolic process|2 iron, 2 sulfur cluster binding|protein maturation by iron-sulfur cluster transfer ISCA2 529.497839787999 540.471959766377 518.523719809622 0.959390603785917 -0.0598097849475479 0.718536817408512 1 23.4272 25.9613 22.8873 24.404 GeneID:122961,Genbank:NM_194279.3,HGNC:HGNC:19857,MIM:615317 iron-sulfur cluster assembly 2 GO:0005198,GO:0005739,GO:0046872,GO:0051536,GO:0097428 structural molecule activity|mitochondrion|metal ion binding|iron-sulfur cluster binding|protein maturation by iron-sulfur cluster transfer ISCU 1168.22361107098 1231.55546806452 1104.89175407744 0.897151433880494 -0.156576570758542 0.294803085050704 1 8.18518 8.35542 7.55461 7.63234 GeneID:23479,Genbank:NM_014301.4,HGNC:HGNC:29882,MIM:611911 iron-sulfur cluster assembly enzyme GO:0005506,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006879,GO:0008198,GO:0016226,GO:0032947,GO:0036455,GO:0044281,GO:0051537,GO:0051539,GO:0097428 iron ion binding|nucleus|cytoplasm|mitochondrion|mitochondrial matrix|cytosol|cellular iron ion homeostasis|ferrous iron binding|iron-sulfur cluster assembly|protein complex scaffold activity|iron-sulfur transferase activity|small molecule metabolic process|2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|protein maturation by iron-sulfur cluster transfer ISG15 1937.72454172826 1186.42392381232 2689.02515964421 2.26649606913152 1.18046365910637 0.45141734123688 1 100.118 116.628 445.489 67.8263 GeneID:9636,Genbank:NM_005101.3,HGNC:HGNC:4053,MIM:147571 ISG15 ubiquitin-like modifier GO:0005576,GO:0005654,GO:0005829,GO:0016032,GO:0019985,GO:0030501,GO:0031397,GO:0032020,GO:0032480,GO:0032649,GO:0034340,GO:0042742,GO:0045071,GO:0051607,GO:0060337 extracellular region|nucleoplasm|cytosol|viral process|translesion synthesis|positive regulation of bone mineralization|negative regulation of protein ubiquitination|ISG15-protein conjugation|negative regulation of type I interferon production|regulation of interferon-gamma production|response to type I interferon|defense response to bacterium|negative regulation of viral genome replication|defense response to virus|type I interferon signaling pathway hsa04622,hsa05165,hsa05169 RIG-I-like receptor signaling pathway|Human papillomavirus infection|Epstein-Barr virus infection ISG20 22.4274195034334 20.1311450998288 24.7236939070379 1.22813152378739 0.296465070932138 0.757988100363266 1 0.0422382 0.14132 0.140132 0.0498289 GeneID:3669,Genbank:XM_017022148.1,HGNC:HGNC:6130,MIM:604533 interferon stimulated exonuclease gene 20 GO:0000175,GO:0000738,GO:0004527,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0006401,GO:0008283,GO:0008310,GO:0008859,GO:0009615,GO:0015030,GO:0016605,GO:0030619,GO:0030620,GO:0034511,GO:0045071,GO:0046872,GO:0051607,GO:0060337 3'-5'-exoribonuclease activity|DNA catabolic process, exonucleolytic|exonuclease activity|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|RNA catabolic process|cell proliferation|single-stranded DNA 3'-5' exodeoxyribonuclease activity|exoribonuclease II activity|response to virus|Cajal body|PML body|U1 snRNA binding|U2 snRNA binding|U3 snoRNA binding|negative regulation of viral genome replication|metal ion binding|defense response to virus|type I interferon signaling pathway ISG20L2 1228.42042936377 1111.02936315004 1345.81149557749 1.21131946662669 0.276579403542605 0.0635765311566388 0.897898872552551 8.98409 9.23088 11.6811 11.1056 GeneID:81875,Genbank:NM_001303095.1,HGNC:HGNC:25745,MIM:611930 interferon stimulated exonuclease gene 20 like 2 GO:0000175,GO:0003723,GO:0005654,GO:0005730,GO:0006364 3'-5'-exoribonuclease activity|RNA binding|nucleoplasm|nucleolus|rRNA processing ISL2 101.152832749001 107.823483084018 94.4821824139837 0.876267207398238 -0.190557225054422 0.601677357315373 1 2.45151 2.73076 2.018 2.86449 GeneID:64843,Genbank:XM_017022505.1,HGNC:HGNC:18524,MIM:609481 ISL LIM homeobox 2 GO:0003677,GO:0005634,GO:0006355,GO:0021520,GO:0021524,GO:0031290,GO:0043565,GO:0045665,GO:0046872,GO:0048666,GO:0048935 DNA binding|nucleus|regulation of transcription, DNA-templated|spinal cord motor neuron cell fate specification|visceral motor neuron differentiation|retinal ganglion cell axon guidance|sequence-specific DNA binding|negative regulation of neuron differentiation|metal ion binding|neuron development|peripheral nervous system neuron development ISLR 8.23771508357291 9.20549543271206 7.26993473443377 0.789738562967485 -0.340552955944107 0.784800369464021 1 0.179453 0.198982 0.189862 0.15526 GeneID:3671,Genbank:NM_005545.3,HGNC:HGNC:6133,MIM:602059 immunoglobulin superfamily containing leucine rich repeat GO:0002576,GO:0005576,GO:0007155,GO:0031093,GO:0070062 platelet degranulation|extracellular region|cell adhesion|platelet alpha granule lumen|extracellular exosome ISLR2 1.7764131480844 1.61429302992691 1.93853326624189 1.20085587331666 0.264063009221118 1 1 0.0244741 0 0.0150879 0.0141004 GeneID:57611,Genbank:XM_024450003.1,HGNC:HGNC:29286,MIM:614179 immunoglobulin superfamily containing leucine rich repeat 2 GO:0005886,GO:0009986,GO:0016021,GO:0045773 plasma membrane|cell surface|integral component of membrane|positive regulation of axon extension ISM1 6.21626623450983 7.10113100082778 5.33140146819188 0.750782018747493 -0.413533996895544 0.773090958523757 1 0.065757 0.0969096 0.0747656 0.0580795 GeneID:140862,Genbank:XM_017027680.1,HGNC:HGNC:16213,MIM:615793 isthmin 1 GO:0005576 extracellular region ISOC1 780.232690237256 845.626453701522 714.838926772989 0.845336523761712 -0.242402310283448 0.128395323323134 1 21.4867 21.4589 19.2158 17.4374 GeneID:51015,Genbank:NM_016048.2,HGNC:HGNC:24254 isochorismatase domain containing 1 GO:0003824,GO:0005737,GO:0005777,GO:0008152,GO:0070062 catalytic activity|cytoplasm|peroxisome|metabolic process|extracellular exosome ISOC2 1384.8530244371 1318.76957730356 1450.93647157063 1.10021985382564 0.137791842232727 0.368832407338845 1 40.2228 44.8436 47.7433 47.8336 GeneID:79763,Genbank:NM_001136202.1,HGNC:HGNC:26278,MIM:612928 isochorismatase domain containing 2 GO:0003824,GO:0005634,GO:0005737,GO:0008152,GO:0031648 catalytic activity|nucleus|cytoplasm|metabolic process|protein destabilization ISPD 19.5014699434928 22.5236671798228 16.4792727071628 0.731642524087966 -0.450789165907978 0.498326951010664 1 0.0267127 0.0365383 0.0388903 0.0241062 GeneID:729920,Genbank:NM_001101417.3,HGNC:HGNC:37276,MIM:614631 isoprenoid synthase domain containing GO:0005829,GO:0007411,GO:0008299,GO:0035269,GO:0042803,GO:0047349,GO:0070567 cytosol|axon guidance|isoprenoid biosynthetic process|protein O-linked mannosylation|protein homodimerization activity|D-ribitol-5-phosphate cytidylyltransferase activity|cytidylyltransferase activity hsa00040,hsa00515 Pentose and glucuronate interconversions|Mannose type O-glycan biosynthesis IST1 3618.08770898591 3570.05704892999 3666.11836904182 1.02690750282005 0.0383062388785346 0.783407086167932 1 33.6258 35.5651 35.7527 36.1497 GeneID:9798,Genbank:NM_001270976.1,HGNC:HGNC:28977,MIM:616434 IST1, ESCRT-III associated factor GO:0000910,GO:0005576,GO:0005635,GO:0005793,GO:0005813,GO:0005829,GO:0008104,GO:0009838,GO:0015031,GO:0019076,GO:0019904,GO:0030496,GO:0032403,GO:0035578,GO:0036258,GO:0042802,GO:0043231,GO:0043312,GO:0045184,GO:0045296,GO:0045862,GO:0046745,GO:0048672,GO:0051301,GO:0070062,GO:0090541,GO:0090543,GO:1904903 cytokinesis|extracellular region|nuclear envelope|endoplasmic reticulum-Golgi intermediate compartment|centrosome|cytosol|protein localization|abscission|protein transport|viral release from host cell|protein domain specific binding|midbody|protein complex binding|azurophil granule lumen|multivesicular body assembly|identical protein binding|intracellular membrane-bounded organelle|neutrophil degranulation|establishment of protein localization|cadherin binding|positive regulation of proteolysis|viral capsid secondary envelopment|positive regulation of collateral sprouting|cell division|extracellular exosome|MIT domain binding|Flemming body|ESCRT III complex disassembly hsa04144 Endocytosis ISY1 210.572269193829 211.303967135321 209.840571252337 0.993074451451039 -0.0100262132739213 0.940501828660686 1 3.85825 4.98826 4.58727 4.38335 GeneID:57461,Genbank:NM_020701.3,HGNC:HGNC:29201,MIM:612764 ISY1 splicing factor homolog GO:0000350,GO:0000389,GO:0000398,GO:0000974,GO:0003723,GO:0005654,GO:0006283,GO:0071012,GO:0071013,GO:0071014,GO:0071020 generation of catalytic spliceosome for second transesterification step|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|Prp19 complex|RNA binding|nucleoplasm|transcription-coupled nucleotide-excision repair|catalytic step 1 spliceosome|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex|post-spliceosomal complex hsa03040 Spliceosome ISYNA1 47.4774973763302 44.0671915557308 50.8878031969296 1.1547775431201 0.207614956967541 0.63694223242667 1 0.415936 0.408747 0.488388 0.484196 GeneID:51477,Genbank:NM_001170938.1,HGNC:HGNC:29821,MIM:611670 inositol-3-phosphate synthase 1 GO:0004512,GO:0005737,GO:0005829,GO:0006021,GO:0008654,GO:0043647 inositol-3-phosphate synthase activity|cytoplasm|cytosol|inositol biosynthetic process|phospholipid biosynthetic process|inositol phosphate metabolic process hsa00562 Inositol phosphate metabolism ITCH 999.099017761425 1054.52605610003 943.671979422818 0.894877821144423 -0.160237372132218 0.423415481756077 1 3.66269 3.42434 3.64266 2.82192 GeneID:83737,Genbank:NM_001324197.1,HGNC:HGNC:13890,MIM:606409 itchy E3 ubiquitin protein ligase GO:0001558,GO:0002669,GO:0004842,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005938,GO:0006511,GO:0006915,GO:0006954,GO:0007219,GO:0016020,GO:0016567,GO:0016874,GO:0019787,GO:0031901,GO:0032088,GO:0032480,GO:0035519,GO:0042787,GO:0043021,GO:0043066,GO:0043161,GO:0043231,GO:0043234,GO:0044389,GO:0045087,GO:0045236,GO:0045732,GO:0046329,GO:0046642,GO:0046718,GO:0050687,GO:0051607,GO:0051865,GO:0061630,GO:0070062,GO:0070423,GO:0070534,GO:0070936,GO:0090085,GO:1902036,GO:1990763,GO:2000646 regulation of cell growth|positive regulation of T cell anergy|ubiquitin-protein transferase activity|nucleoplasm|cytoplasm|cytosol|plasma membrane|cell cortex|ubiquitin-dependent protein catabolic process|apoptotic process|inflammatory response|Notch signaling pathway|membrane|protein ubiquitination|ligase activity|ubiquitin-like protein transferase activity|early endosome membrane|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ribonucleoprotein complex binding|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|protein complex|ubiquitin-like protein ligase binding|innate immune response|CXCR chemokine receptor binding|positive regulation of protein catabolic process|negative regulation of JNK cascade|negative regulation of alpha-beta T cell proliferation|viral entry into host cell|negative regulation of defense response to virus|defense response to virus|protein autoubiquitination|ubiquitin protein ligase activity|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|protein K63-linked ubiquitination|protein K48-linked ubiquitination|regulation of protein deubiquitination|regulation of hematopoietic stem cell differentiation|arrestin family protein binding|positive regulation of receptor catabolic process hsa04120,hsa04144,hsa04668,hsa04932 Ubiquitin mediated proteolysis|Endocytosis|TNF signaling pathway|Non-alcoholic fatty liver disease (NAFLD) ITFG1 1612.43614278234 1531.93370949393 1692.93857607075 1.10509910812656 0.144175760015778 0.307180799835293 1 18.9708 18.6429 23.2203 18.7534 GeneID:81533,Genbank:NM_001305002.1,HGNC:HGNC:30697,MIM:611803 integrin alpha FG-GAP repeat containing 1 GO:0016021,GO:0070062 integral component of membrane|extracellular exosome ITFG2 301.238143890387 313.159332500734 289.316955280041 0.923865027331935 -0.114245999330851 0.576464428631494 1 2.7351 2.93736 2.63354 2.59965 GeneID:55846,Genbank:NM_018463.3,HGNC:HGNC:30879,MIM:617421 integrin alpha FG-GAP repeat containing 2 GO:0002314,GO:0005654,GO:0005765,GO:0005829,GO:0034198,GO:0042149,GO:0140007,GO:1904262 germinal center B cell differentiation|nucleoplasm|lysosomal membrane|cytosol|cellular response to amino acid starvation|cellular response to glucose starvation|KICSTOR complex|negative regulation of TORC1 signaling ITGA1 81.8515633241252 70.6457001201594 93.0574265280911 1.31724119613525 0.397519537400169 0.21445307063658 1 0.549031 0.391994 0.717198 0.561747 GeneID:3672,Genbank:NM_181501.1,HGNC:HGNC:6134,MIM:192968 integrin subunit alpha 1 GO:0000187,GO:0001669,GO:0005102,GO:0005518,GO:0005886,GO:0005925,GO:0006936,GO:0007160,GO:0007229,GO:0008285,GO:0008305,GO:0009897,GO:0009986,GO:0016020,GO:0019903,GO:0030198,GO:0030593,GO:0032516,GO:0034665,GO:0042059,GO:0042311,GO:0043005,GO:0043204,GO:0043525,GO:0045121,GO:0045123,GO:0045178,GO:0046872,GO:0048812,GO:0070062,GO:0098639 activation of MAPK activity|acrosomal vesicle|receptor binding|collagen binding|plasma membrane|focal adhesion|muscle contraction|cell-matrix adhesion|integrin-mediated signaling pathway|negative regulation of cell proliferation|integrin complex|external side of plasma membrane|cell surface|membrane|protein phosphatase binding|extracellular matrix organization|neutrophil chemotaxis|positive regulation of phosphoprotein phosphatase activity|integrin alpha1-beta1 complex|negative regulation of epidermal growth factor receptor signaling pathway|vasodilation|neuron projection|perikaryon|positive regulation of neuron apoptotic process|membrane raft|cellular extravasation|basal part of cell|metal ion binding|neuron projection morphogenesis|extracellular exosome|collagen binding involved in cell-matrix adhesion hsa04151,hsa04510,hsa04512,hsa04640,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGA10 14.1070199963106 14.644307128928 13.5697328636932 0.92662170659395 -0.109947616240927 0.908438208440744 1 0.0425681 0.110157 0.0738877 0.0689547 GeneID:8515,Genbank:NM_001303041.1,HGNC:HGNC:6135,MIM:604042 integrin subunit alpha 10 GO:0005518,GO:0005886,GO:0007160,GO:0007229,GO:0008305,GO:0030198,GO:0034680,GO:0046872,GO:0098639 collagen binding|plasma membrane|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|extracellular matrix organization|integrin alpha10-beta1 complex|metal ion binding|collagen binding involved in cell-matrix adhesion hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGA11 20.1597158609329 13.6641643250133 26.6552673968526 1.95074259668103 0.964023424799275 0.14005482882139 1 0.0290235 0.0492947 0.0752757 0.0639081 GeneID:22801,Genbank:XM_011521363.2,HGNC:HGNC:6136,MIM:604789 integrin subunit alpha 11 hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGA2 539.018299853485 561.792936077366 516.243663629603 0.918921599894431 -0.12198631527555 0.753263897153095 1 2.81282 2.44942 3.11829 1.82285 GeneID:3673,Genbank:NM_002203.3,HGNC:HGNC:6137,MIM:192974 integrin subunit alpha 2 hsa04145,hsa04151,hsa04510,hsa04512,hsa04611,hsa04640,hsa04810,hsa05165,hsa05200,hsa05205,hsa05222,hsa05410,hsa05412,hsa05414 Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGA2B 7.89422405535547 9.00358167886435 6.7848664318466 0.753574152359153 -0.408178613618713 0.815250374748895 1 0.0848432 0.024544 0.0525167 0.0367348 GeneID:3674,Genbank:NM_000419.4,HGNC:HGNC:6138,MIM:607759 integrin subunit alpha 2b GO:0002576,GO:0002687,GO:0005886,GO:0005925,GO:0007160,GO:0007229,GO:0008305,GO:0009897,GO:0009986,GO:0030198,GO:0031092,GO:0042802,GO:0045652,GO:0046872,GO:0050840,GO:0070051,GO:0070062,GO:0070527,GO:0072562 platelet degranulation|positive regulation of leukocyte migration|plasma membrane|focal adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|external side of plasma membrane|cell surface|extracellular matrix organization|platelet alpha granule membrane|identical protein binding|regulation of megakaryocyte differentiation|metal ion binding|extracellular matrix binding|fibrinogen binding|extracellular exosome|platelet aggregation|blood microparticle hsa04015,hsa04151,hsa04510,hsa04512,hsa04611,hsa04640,hsa04810,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414,hsa05418 Rap1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Fluid shear stress and atherosclerosis ITGA3 42947.6134015949 44708.6612326303 41186.5655705595 0.921221178067836 -0.118380517080267 0.340226820042623 1 324.31 345.425 316.754 312.509 GeneID:3675,Genbank:NM_002204.3,HGNC:HGNC:6139,MIM:605025 integrin subunit alpha 3 GO:0001764,GO:0001968,GO:0002020,GO:0005178,GO:0005518,GO:0005886,GO:0005925,GO:0007160,GO:0007229,GO:0007507,GO:0007613,GO:0008305,GO:0009897,GO:0009986,GO:0010628,GO:0010634,GO:0010811,GO:0010976,GO:0016323,GO:0017015,GO:0019904,GO:0030111,GO:0030198,GO:0030324,GO:0030426,GO:0030510,GO:0031345,GO:0031527,GO:0034667,GO:0034698,GO:0035024,GO:0035640,GO:0042493,GO:0043235,GO:0043236,GO:0043588,GO:0046872,GO:0046982,GO:0048333,GO:0048471,GO:0050900,GO:0060076,GO:0060135,GO:0070062,GO:0071438,GO:0071944,GO:0072006,GO:0097060,GO:0097062,GO:0097205,GO:1903078 neuron migration|fibronectin binding|protease binding|integrin binding|collagen binding|plasma membrane|focal adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|heart development|memory|integrin complex|external side of plasma membrane|cell surface|positive regulation of gene expression|positive regulation of epithelial cell migration|positive regulation of cell-substrate adhesion|positive regulation of neuron projection development|basolateral plasma membrane|regulation of transforming growth factor beta receptor signaling pathway|protein domain specific binding|regulation of Wnt signaling pathway|extracellular matrix organization|lung development|growth cone|regulation of BMP signaling pathway|negative regulation of cell projection organization|filopodium membrane|integrin alpha3-beta1 complex|response to gonadotropin|negative regulation of Rho protein signal transduction|exploration behavior|response to drug|receptor complex|laminin binding|skin development|metal ion binding|protein heterodimerization activity|mesodermal cell differentiation|perinuclear region of cytoplasm|leukocyte migration|excitatory synapse|maternal process involved in female pregnancy|extracellular exosome|invadopodium membrane|cell periphery|nephron development|synaptic membrane|dendritic spine maintenance|renal filtration|positive regulation of protein localization to plasma membrane hsa04151,hsa04510,hsa04512,hsa04640,hsa04810,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGA4 248.350742334159 289.241886354193 207.459598314124 0.71725295713249 -0.479446083853571 0.119714035864956 1 1.60296 1.32773 1.26138 0.790397 GeneID:3676,Genbank:NM_000885.5,HGNC:HGNC:6140,MIM:192975 integrin subunit alpha 4 GO:0001968,GO:0003366,GO:0005886,GO:0005925,GO:0007159,GO:0007160,GO:0007229,GO:0009986,GO:0015026,GO:0016020,GO:0030183,GO:0030198,GO:0034113,GO:0034446,GO:0034669,GO:0035987,GO:0043113,GO:0046872,GO:0050776,GO:0050839,GO:0050900,GO:0050901,GO:0050904,GO:0070062,GO:0071345,GO:0090074,GO:1903238,GO:1990405,GO:1990771,GO:2000406 fibronectin binding|cell-matrix adhesion involved in ameboidal cell migration|plasma membrane|focal adhesion|leukocyte cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|cell surface|coreceptor activity|membrane|B cell differentiation|extracellular matrix organization|heterotypic cell-cell adhesion|substrate adhesion-dependent cell spreading|integrin alpha4-beta7 complex|endodermal cell differentiation|receptor clustering|metal ion binding|regulation of immune response|cell adhesion molecule binding|leukocyte migration|leukocyte tethering or rolling|diapedesis|extracellular exosome|cellular response to cytokine stimulus|negative regulation of protein homodimerization activity|positive regulation of leukocyte tethering or rolling|protein antigen binding|clathrin-dependent extracellular exosome endocytosis|positive regulation of T cell migration hsa04151,hsa04510,hsa04512,hsa04514,hsa04640,hsa04670,hsa04672,hsa04810,hsa05140,hsa05165,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules (CAMs)|Hematopoietic cell lineage|Leukocyte transendothelial migration|Intestinal immune network for IgA production|Regulation of actin cytoskeleton|Leishmaniasis|Human papillomavirus infection|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGA5 3533.43950693671 3983.15069580874 3083.72831806468 0.774193233841121 -0.369234395816318 0.00614355348986849 0.313360358897241 26.9992 27.3727 22.3548 20.4691 GeneID:3678,Genbank:NM_002205.4,HGNC:HGNC:6141,MIM:135620 integrin subunit alpha 5 GO:0001525,GO:0001618,GO:0001726,GO:0005154,GO:0005161,GO:0005178,GO:0005783,GO:0005794,GO:0005886,GO:0005925,GO:0007044,GO:0007155,GO:0007157,GO:0007159,GO:0007229,GO:0007613,GO:0008305,GO:0009897,GO:0009986,GO:0010811,GO:0030198,GO:0030335,GO:0030949,GO:0031410,GO:0031589,GO:0033627,GO:0033631,GO:0034113,GO:0035313,GO:0035987,GO:0043184,GO:0045202,GO:0046872,GO:0050731,GO:0050900,GO:0071062,GO:1903672,GO:2000811 angiogenesis|virus receptor activity|ruffle|epidermal growth factor receptor binding|platelet-derived growth factor receptor binding|integrin binding|endoplasmic reticulum|Golgi apparatus|plasma membrane|focal adhesion|cell-substrate junction assembly|cell adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|leukocyte cell-cell adhesion|integrin-mediated signaling pathway|memory|integrin complex|external side of plasma membrane|cell surface|positive regulation of cell-substrate adhesion|extracellular matrix organization|positive regulation of cell migration|positive regulation of vascular endothelial growth factor receptor signaling pathway|cytoplasmic vesicle|cell-substrate adhesion|cell adhesion mediated by integrin|cell-cell adhesion mediated by integrin|heterotypic cell-cell adhesion|wound healing, spreading of epidermal cells|endodermal cell differentiation|vascular endothelial growth factor receptor 2 binding|synapse|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|alphav-beta3 integrin-vitronectin complex|positive regulation of sprouting angiogenesis|negative regulation of anoikis hsa04145,hsa04151,hsa04510,hsa04512,hsa04640,hsa04810,hsa05100,hsa05131,hsa05133,hsa05165,hsa05205,hsa05206,hsa05410,hsa05412,hsa05414 Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Pertussis|Human papillomavirus infection|Proteoglycans in cancer|MicroRNAs in cancer|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGA6 1079.06247716024 969.630067703531 1188.49488661696 1.22571991752667 0.293629354429916 0.291241097678045 1 6.62475 5.74338 9.32797 6.07981 GeneID:3655,Genbank:NM_001316306.1,HGNC:HGNC:6142,MIM:147556 integrin subunit alpha 6 GO:0005178,GO:0005604,GO:0005886,GO:0005913,GO:0005925,GO:0007044,GO:0007160,GO:0007229,GO:0009897,GO:0009925,GO:0009986,GO:0010668,GO:0010811,GO:0022409,GO:0030056,GO:0030175,GO:0030198,GO:0030335,GO:0031581,GO:0031589,GO:0031668,GO:0031994,GO:0033627,GO:0034676,GO:0035878,GO:0038132,GO:0042327,GO:0043065,GO:0043236,GO:0043547,GO:0043588,GO:0045296,GO:0045944,GO:0046847,GO:0046872,GO:0048565,GO:0050873,GO:0050900,GO:0071407,GO:0072001,GO:0097186,GO:0098609,GO:2001237 integrin binding|basement membrane|plasma membrane|cell-cell adherens junction|focal adhesion|cell-substrate junction assembly|cell-matrix adhesion|integrin-mediated signaling pathway|external side of plasma membrane|basal plasma membrane|cell surface|ectodermal cell differentiation|positive regulation of cell-substrate adhesion|positive regulation of cell-cell adhesion|hemidesmosome|filopodium|extracellular matrix organization|positive regulation of cell migration|hemidesmosome assembly|cell-substrate adhesion|cellular response to extracellular stimulus|insulin-like growth factor I binding|cell adhesion mediated by integrin|integrin alpha6-beta4 complex|nail development|neuregulin binding|positive regulation of phosphorylation|positive regulation of apoptotic process|laminin binding|positive regulation of GTPase activity|skin development|cadherin binding|positive regulation of transcription from RNA polymerase II promoter|filopodium assembly|metal ion binding|digestive tract development|brown fat cell differentiation|leukocyte migration|cellular response to organic cyclic compound|renal system development|amelogenesis|cell-cell adhesion|negative regulation of extrinsic apoptotic signaling pathway hsa04151,hsa04510,hsa04512,hsa04514,hsa04640,hsa04810,hsa05145,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules (CAMs)|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Toxoplasmosis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGA7 1854.71368136605 1852.91761811833 1856.50974461377 1.00193863259776 0.00279414809585644 1 1 12.7532 12.8942 12.6135 13.7497 GeneID:3679,Genbank:XM_005268848.1,HGNC:HGNC:6143,MIM:600536 integrin subunit alpha 7 GO:0005886,GO:0007160,GO:0007229,GO:0007517,GO:0008305,GO:0008360,GO:0009986,GO:0030198,GO:0034113,GO:0035987,GO:0046872 plasma membrane|cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|integrin complex|regulation of cell shape|cell surface|extracellular matrix organization|heterotypic cell-cell adhesion|endodermal cell differentiation|metal ion binding hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGA9 19.5139182638898 11.4059124139662 27.6219241138134 2.42171981611845 1.27603196029281 0.048467743800676 0.806708656465773 0.0907863 0.0640475 0.219541 0.23087 GeneID:3680,Genbank:NM_002207.2,HGNC:HGNC:6145,MIM:603963 integrin subunit alpha 9 GO:0005518,GO:0005886,GO:0007155,GO:0007229,GO:0008305,GO:0009925,GO:0030198,GO:0030593,GO:0034679,GO:0042060,GO:0043236,GO:0046872 collagen binding|plasma membrane|cell adhesion|integrin-mediated signaling pathway|integrin complex|basal plasma membrane|extracellular matrix organization|neutrophil chemotaxis|integrin alpha9-beta1 complex|wound healing|laminin binding|metal ion binding hsa04151,hsa04510,hsa04512,hsa04514,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules (CAMs)|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGAD 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0 0 0 GeneID:3681,Genbank:XM_011545845.3,HGNC:HGNC:6146,MIM:602453 integrin subunit alpha D GO:0005886,GO:0006955,GO:0007229,GO:0008305,GO:0009986,GO:0030198,GO:0034113,GO:0046872 plasma membrane|immune response|integrin-mediated signaling pathway|integrin complex|cell surface|extracellular matrix organization|heterotypic cell-cell adhesion|metal ion binding hsa04810 Regulation of actin cytoskeleton ITGAE 776.685989858785 845.435365603637 707.936614113934 0.837363378581248 -0.256074270545144 0.305610258332119 1 2.61074 3.05974 2.17858 2.73886 GeneID:3682,Genbank:NM_002208.4,HGNC:HGNC:6147,MIM:604682 integrin subunit alpha E GO:0005886,GO:0007155,GO:0007229,GO:0008305,GO:0009897,GO:0030198,GO:0046872 plasma membrane|cell adhesion|integrin-mediated signaling pathway|integrin complex|external side of plasma membrane|extracellular matrix organization|metal ion binding hsa04810 Regulation of actin cytoskeleton ITGAL 1.2374454993887 0.538097676642304 1.93679332213509 3.5993341101574 1.84773002743481 0.680703344325985 1 0 0 0 0.0193618 GeneID:3683,Genbank:NM_002209.2,HGNC:HGNC:6148,MIM:153370 integrin subunit alpha L hsa04015,hsa04514,hsa04650,hsa04670,hsa04810,hsa05144,hsa05150,hsa05166,hsa05169,hsa05323,hsa05416 Rap1 signaling pathway|Cell adhesion molecules (CAMs)|Natural killer cell mediated cytotoxicity|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Malaria|Staphylococcus aureus infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Rheumatoid arthritis|Viral myocarditis ITGAM 2.0024388110908 3.03648096111406 0.968396661067546 0.31892070902768 -1.64873031325362 0.553635813642693 1 0.00888352 0.0158303 0 0.0155466 GeneID:3684,Genbank:NM_001145808.1,HGNC:HGNC:6149,MIM:120980 integrin subunit alpha M GO:0001774,GO:0001851,GO:0005615,GO:0005886,GO:0006911,GO:0007155,GO:0007229,GO:0008305,GO:0009897,GO:0009986,GO:0010668,GO:0019221,GO:0030198,GO:0031072,GO:0032930,GO:0034142,GO:0034688,GO:0035579,GO:0043312,GO:0043315,GO:0044853,GO:0045087,GO:0045963,GO:0046872,GO:0046982,GO:0050900,GO:0070062,GO:0070821,GO:0090314,GO:0097242,GO:0098742,GO:1901216,GO:1903980,GO:2000363 microglial cell activation|complement component C3b binding|extracellular space|plasma membrane|phagocytosis, engulfment|cell adhesion|integrin-mediated signaling pathway|integrin complex|external side of plasma membrane|cell surface|ectodermal cell differentiation|cytokine-mediated signaling pathway|extracellular matrix organization|heat shock protein binding|positive regulation of superoxide anion generation|toll-like receptor 4 signaling pathway|integrin alphaM-beta2 complex|specific granule membrane|neutrophil degranulation|positive regulation of neutrophil degranulation|plasma membrane raft|innate immune response|negative regulation of dopamine metabolic process|metal ion binding|protein heterodimerization activity|leukocyte migration|extracellular exosome|tertiary granule membrane|positive regulation of protein targeting to membrane|amyloid-beta clearance|cell-cell adhesion via plasma-membrane adhesion molecules|positive regulation of neuron death|positive regulation of microglial cell activation|positive regulation of prostaglandin-E synthase activity hsa04015,hsa04145,hsa04514,hsa04610,hsa04640,hsa04670,hsa04810,hsa05133,hsa05134,hsa05140,hsa05146,hsa05150,hsa05152,hsa05202,hsa05221 Rap1 signaling pathway|Phagosome|Cell adhesion molecules (CAMs)|Complement and coagulation cascades|Hematopoietic cell lineage|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Pertussis|Legionellosis|Leishmaniasis|Amoebiasis|Staphylococcus aureus infection|Tuberculosis|Transcriptional misregulation in cancer|Acute myeloid leukemia ITGAV 2052.58022395061 2296.25226874179 1808.90817915943 0.787765440140688 -0.344161968658064 0.312521341646801 1 15.7278 11.9765 13.157 8.97897 GeneID:3685,Genbank:NM_002210.4,HGNC:HGNC:6150,MIM:193210 integrin subunit alpha V GO:0001525,GO:0001570,GO:0001618,GO:0001846,GO:0001968,GO:0002020,GO:0002479,GO:0005080,GO:0005178,GO:0005245,GO:0005829,GO:0005886,GO:0005887,GO:0005925,GO:0007155,GO:0007160,GO:0007204,GO:0007229,GO:0008284,GO:0008305,GO:0009897,GO:0009986,GO:0010745,GO:0010888,GO:0015026,GO:0016020,GO:0030198,GO:0030335,GO:0031258,GO:0031527,GO:0031528,GO:0031589,GO:0032369,GO:0032587,GO:0033627,GO:0033690,GO:0034113,GO:0034446,GO:0034683,GO:0034684,GO:0034685,GO:0034686,GO:0035579,GO:0035866,GO:0035867,GO:0035868,GO:0035987,GO:0038027,GO:0038044,GO:0042277,GO:0043277,GO:0043312,GO:0043410,GO:0045335,GO:0045715,GO:0045785,GO:0046718,GO:0046872,GO:0048010,GO:0050431,GO:0050748,GO:0050764,GO:0050840,GO:0050900,GO:0050919,GO:0052066,GO:0070062,GO:0070371,GO:0070588,GO:0097192,GO:1990430,GO:2000536,GO:2001237 angiogenesis|vasculogenesis|virus receptor activity|opsonin binding|fibronectin binding|protease binding|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|protein kinase C binding|integrin binding|voltage-gated calcium channel activity|cytosol|plasma membrane|integral component of plasma membrane|focal adhesion|cell adhesion|cell-matrix adhesion|positive regulation of cytosolic calcium ion concentration|integrin-mediated signaling pathway|positive regulation of cell proliferation|integrin complex|external side of plasma membrane|cell surface|negative regulation of macrophage derived foam cell differentiation|negative regulation of lipid storage|coreceptor activity|membrane|extracellular matrix organization|positive regulation of cell migration|lamellipodium membrane|filopodium membrane|microvillus membrane|cell-substrate adhesion|negative regulation of lipid transport|ruffle membrane|cell adhesion mediated by integrin|positive regulation of osteoblast proliferation|heterotypic cell-cell adhesion|substrate adhesion-dependent cell spreading|integrin alphav-beta3 complex|integrin alphav-beta5 complex|integrin alphav-beta6 complex|integrin alphav-beta8 complex|specific granule membrane|alphav-beta3 integrin-PKCalpha complex|alphav-beta3 integrin-IGF-1-IGF1R complex|alphav-beta3 integrin-HMGB1 complex|endodermal cell differentiation|apolipoprotein A-I-mediated signaling pathway|transforming growth factor-beta secretion|peptide binding|apoptotic cell clearance|neutrophil degranulation|positive regulation of MAPK cascade|phagocytic vesicle|negative regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of cell adhesion|viral entry into host cell|metal ion binding|vascular endothelial growth factor receptor signaling pathway|transforming growth factor beta binding|negative regulation of lipoprotein metabolic process|regulation of phagocytosis|extracellular matrix binding|leukocyte migration|negative chemotaxis|entry of symbiont into host cell by promotion of host phagocytosis|extracellular exosome|ERK1 and ERK2 cascade|calcium ion transmembrane transport|extrinsic apoptotic signaling pathway in absence of ligand|extracellular matrix protein binding|negative regulation of entry of bacterium into host cell|negative regulation of extrinsic apoptotic signaling pathway hsa04145,hsa04151,hsa04510,hsa04512,hsa04514,hsa04810,hsa04919,hsa05163,hsa05165,hsa05200,hsa05205,hsa05222,hsa05410,hsa05412,hsa05414,hsa05418 Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules (CAMs)|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Fluid shear stress and atherosclerosis ITGAX 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00821117 0 0.00765962 0 GeneID:3687,Genbank:NM_000887.4,HGNC:HGNC:6152,MIM:151510 integrin subunit alpha X GO:0004872,GO:0005886,GO:0007155,GO:0007229,GO:0008305,GO:0009887,GO:0009986,GO:0016020,GO:0019221,GO:0030198,GO:0030667,GO:0034113,GO:0043312,GO:0046872,GO:0050900,GO:0070821,GO:0101003,GO:1903955 receptor activity|plasma membrane|cell adhesion|integrin-mediated signaling pathway|integrin complex|animal organ morphogenesis|cell surface|membrane|cytokine-mediated signaling pathway|extracellular matrix organization|secretory granule membrane|heterotypic cell-cell adhesion|neutrophil degranulation|metal ion binding|leukocyte migration|tertiary granule membrane|ficolin-1-rich granule membrane|positive regulation of protein targeting to mitochondrion hsa04610,hsa04810,hsa05152 Complement and coagulation cascades|Regulation of actin cytoskeleton|Tuberculosis ITGB1 8418.94101713102 8831.65749120682 8006.22454305522 0.906537028980863 -0.141562144486599 0.446019758120883 1 77.6926 67.5941 73.6943 58.7388 GeneID:3688,Genbank:NM_002211.3,HGNC:HGNC:6153,MIM:135630 integrin subunit beta 1 hsa04015,hsa04145,hsa04151,hsa04360,hsa04510,hsa04512,hsa04514,hsa04530,hsa04611,hsa04670,hsa04810,hsa05100,hsa05130,hsa05131,hsa05133,hsa05140,hsa05145,hsa05165,hsa05200,hsa05205,hsa05222,hsa05410,hsa05412,hsa05414 Rap1 signaling pathway|Phagosome|PI3K-Akt signaling pathway|Axon guidance|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules (CAMs)|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Pertussis|Leishmaniasis|Toxoplasmosis|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGB1BP1 1099.79810944157 1095.14516453355 1104.45105434958 1.00849740300866 0.0122073688578111 0.938703394766712 1 5.74543 5.97514 5.76317 5.93676 GeneID:9270,Genbank:NM_001319069.1,HGNC:HGNC:23927,MIM:607153 integrin subunit beta 1 binding protein 1 GO:0001726,GO:0002043,GO:0005092,GO:0005178,GO:0005634,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0006351,GO:0006469,GO:0006933,GO:0007160,GO:0007219,GO:0007229,GO:0008284,GO:0008285,GO:0008565,GO:0010595,GO:0010764,GO:0015031,GO:0016020,GO:0016477,GO:0016604,GO:0019901,GO:0030027,GO:0030154,GO:0031214,GO:0032091,GO:0032148,GO:0032403,GO:0033622,GO:0033628,GO:0035148,GO:0035556,GO:0035924,GO:0043087,GO:0043113,GO:0044344,GO:0045747,GO:0045944,GO:0048471,GO:0050880,GO:0051451,GO:0051496,GO:0051781,GO:0051894,GO:0051895,GO:0051897,GO:0070062,GO:0070373,GO:0071944,GO:0090051,GO:0090314,GO:0090315,GO:1900025,GO:2001044 ruffle|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|GDP-dissociation inhibitor activity|integrin binding|nucleus|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|cytoskeleton|plasma membrane|transcription, DNA-templated|negative regulation of protein kinase activity|negative regulation of cell adhesion involved in substrate-bound cell migration|cell-matrix adhesion|Notch signaling pathway|integrin-mediated signaling pathway|positive regulation of cell proliferation|negative regulation of cell proliferation|protein transporter activity|positive regulation of endothelial cell migration|negative regulation of fibroblast migration|protein transport|membrane|cell migration|nuclear body|protein kinase binding|lamellipodium|cell differentiation|biomineral tissue development|negative regulation of protein binding|activation of protein kinase B activity|protein complex binding|integrin activation|regulation of cell adhesion mediated by integrin|tube formation|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|regulation of GTPase activity|receptor clustering|cellular response to fibroblast growth factor stimulus|positive regulation of Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|perinuclear region of cytoplasm|regulation of blood vessel size|myoblast migration|positive regulation of stress fiber assembly|positive regulation of cell division|positive regulation of focal adhesion assembly|negative regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|cell periphery|negative regulation of cell migration involved in sprouting angiogenesis|positive regulation of protein targeting to membrane|negative regulation of protein targeting to membrane|negative regulation of substrate adhesion-dependent cell spreading|regulation of integrin-mediated signaling pathway ITGB1BP2 4.23283746139131 3.13253351048394 5.33314141229868 1.70250099303001 0.76765563972871 0.650135033485702 1 0.0654672 0.0300263 0.123586 0.0865154 GeneID:26548,Genbank:NM_012278.3,HGNC:HGNC:6154,MIM:300332 integrin subunit beta 1 binding protein 2 GO:0005178,GO:0005509,GO:0007165,GO:0007517,GO:0008270,GO:0017124,GO:0030018 integrin binding|calcium ion binding|signal transduction|muscle organ development|zinc ion binding|SH3 domain binding|Z disc ITGB2 7.46252134103391 9.10944288334217 5.81559979872566 0.638414431398462 -0.647434830746163 0.567952015160479 1 0.0509751 0.0664007 0.0708926 0.0331634 GeneID:3689,Genbank:XM_006724001.2,HGNC:HGNC:6155,MIM:600065 integrin subunit beta 2 hsa04015,hsa04145,hsa04390,hsa04514,hsa04610,hsa04650,hsa04670,hsa04810,hsa05133,hsa05134,hsa05140,hsa05144,hsa05146,hsa05150,hsa05152,hsa05166,hsa05323,hsa05416 Rap1 signaling pathway|Phagosome|Hippo signaling pathway|Cell adhesion molecules (CAMs)|Complement and coagulation cascades|Natural killer cell mediated cytotoxicity|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Pertussis|Legionellosis|Leishmaniasis|Malaria|Amoebiasis|Staphylococcus aureus infection|Tuberculosis|Human T-cell leukemia virus 1 infection|Rheumatoid arthritis|Viral myocarditis ITGB3 412.32632447667 491.234496852324 333.418152101017 0.678735215538517 -0.559079226945045 0.00229800477832747 0.174430542794752 3.75443 3.79601 2.6118 2.57446 GeneID:3690,Genbank:NM_000212.2,HGNC:HGNC:6156,MIM:173470 integrin subunit beta 3 hsa04015,hsa04145,hsa04151,hsa04380,hsa04510,hsa04512,hsa04611,hsa04640,hsa04810,hsa04919,hsa05163,hsa05165,hsa05205,hsa05206,hsa05410,hsa05412,hsa05414,hsa05418 Rap1 signaling pathway|Phagosome|PI3K-Akt signaling pathway|Osteoclast differentiation|Focal adhesion|ECM-receptor interaction|Platelet activation|Hematopoietic cell lineage|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Proteoglycans in cancer|MicroRNAs in cancer|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Fluid shear stress and atherosclerosis ITGB3BP 312.095734175894 331.954533563637 292.236934788151 0.880352292980893 -0.183847128377491 0.361402920941115 1 1.77393 1.67573 1.33759 1.42815 GeneID:23421,Genbank:XM_017000855.2,HGNC:HGNC:6157,MIM:605494 integrin subunit beta 3 binding protein GO:0000777,GO:0004871,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0006915,GO:0007062,GO:0007155,GO:0007165,GO:0008022,GO:0016020,GO:0034080,GO:0043065,GO:0051301 condensed chromosome kinetochore|signal transducer activity|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|sister chromatid cohesion|cell adhesion|signal transduction|protein C-terminus binding|membrane|CENP-A containing nucleosome assembly|positive regulation of apoptotic process|cell division ITGB4 17142.6239299033 14476.2550838546 19808.9927759519 1.36837826227895 0.452467091101344 0.000520531428970626 0.0646265997394848 66.6976 71.0414 95.6685 98.1138 GeneID:3691,Genbank:NM_000213.4,HGNC:HGNC:6158,MIM:147557 integrin subunit beta 4 GO:0001664,GO:0004872,GO:0005886,GO:0006914,GO:0007155,GO:0007160,GO:0007229,GO:0008305,GO:0009611,GO:0009986,GO:0030054,GO:0030056,GO:0030198,GO:0031252,GO:0031581,GO:0035878,GO:0043235,GO:0043588,GO:0048333,GO:0048565,GO:0048870,GO:0070062,GO:0072001,GO:0097186 G-protein coupled receptor binding|receptor activity|plasma membrane|autophagy|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|response to wounding|cell surface|cell junction|hemidesmosome|extracellular matrix organization|cell leading edge|hemidesmosome assembly|nail development|receptor complex|skin development|mesodermal cell differentiation|digestive tract development|cell motility|extracellular exosome|renal system development|amelogenesis hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGB5 5495.8783642139 5060.21429574712 5931.54243268069 1.17219194405776 0.229208827496289 0.087182064610498 0.968313416644754 37.2134 39.0112 48.0551 42.5906 GeneID:3693,Genbank:NM_001354766.1,HGNC:HGNC:6160,MIM:147561 integrin subunit beta 5 GO:0001618,GO:0002479,GO:0004872,GO:0005886,GO:0005925,GO:0006936,GO:0007160,GO:0007179,GO:0007229,GO:0009986,GO:0030198,GO:0034684,GO:0035987,GO:0043149,GO:0043235,GO:0045335,GO:0070062,GO:0090136 virus receptor activity|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|receptor activity|plasma membrane|focal adhesion|muscle contraction|cell-matrix adhesion|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|cell surface|extracellular matrix organization|integrin alphav-beta5 complex|endodermal cell differentiation|stress fiber assembly|receptor complex|phagocytic vesicle|extracellular exosome|epithelial cell-cell adhesion hsa04145,hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05205,hsa05410,hsa05412,hsa05414 Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Proteoglycans in cancer|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGB6 1.4647761204752 1.96028560782945 0.969266633120943 0.49445174175113 -1.01609837336455 0.813651560116793 1 0 0.0182883 0.00916957 0.00853562 GeneID:3694,Genbank:NM_001282353.1,HGNC:HGNC:6161,MIM:147558 integrin subunit beta 6 GO:0001618,GO:0004872,GO:0005178,GO:0005654,GO:0005813,GO:0005886,GO:0005925,GO:0006954,GO:0007155,GO:0007160,GO:0007229,GO:0008305,GO:0009897,GO:0030054,GO:0030198,GO:0033627,GO:0034685,GO:0038044,GO:0043235,GO:0070062 virus receptor activity|receptor activity|integrin binding|nucleoplasm|centrosome|plasma membrane|focal adhesion|inflammatory response|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|external side of plasma membrane|cell junction|extracellular matrix organization|cell adhesion mediated by integrin|integrin alphav-beta6 complex|transforming growth factor-beta secretion|receptor complex|extracellular exosome hsa04151,hsa04510,hsa04512,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGB7 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0.0167158 0.0292446 0 0 GeneID:3695,Genbank:XM_006719376.4,HGNC:HGNC:6162,MIM:147559 integrin subunit beta 7 GO:0001618,GO:0003366,GO:0004872,GO:0005886,GO:0007155,GO:0007160,GO:0007229,GO:0008305,GO:0009986,GO:0016020,GO:0030198,GO:0034113,GO:0034446,GO:0034669,GO:0043113,GO:0043235,GO:0046872,GO:0050776,GO:0050839,GO:0050901,GO:0070062,GO:0072678 virus receptor activity|cell-matrix adhesion involved in ameboidal cell migration|receptor activity|plasma membrane|cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|integrin complex|cell surface|membrane|extracellular matrix organization|heterotypic cell-cell adhesion|substrate adhesion-dependent cell spreading|integrin alpha4-beta7 complex|receptor clustering|receptor complex|metal ion binding|regulation of immune response|cell adhesion molecule binding|leukocyte tethering or rolling|extracellular exosome|T cell migration hsa04151,hsa04510,hsa04512,hsa04514,hsa04672,hsa04810,hsa05165,hsa05202,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules (CAMs)|Intestinal immune network for IgA production|Regulation of actin cytoskeleton|Human papillomavirus infection|Transcriptional misregulation in cancer|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGB8 1352.07005564884 1141.3038608635 1562.83625043419 1.36934282273589 0.453483678695348 0.348010657455099 1 5.65519 4.41219 9.21171 4.78048 GeneID:3696,Genbank:XM_011515393.2,HGNC:HGNC:6163,MIM:604160 integrin subunit beta 8 GO:0001573,GO:0004872,GO:0005102,GO:0005886,GO:0007155,GO:0007229,GO:0008305,GO:0009986,GO:0010628,GO:0010629,GO:0030198,GO:0034686,GO:0051216,GO:0060674,GO:0070062,GO:1990430 ganglioside metabolic process|receptor activity|receptor binding|plasma membrane|cell adhesion|integrin-mediated signaling pathway|integrin complex|cell surface|positive regulation of gene expression|negative regulation of gene expression|extracellular matrix organization|integrin alphav-beta8 complex|cartilage development|placenta blood vessel development|extracellular exosome|extracellular matrix protein binding hsa04151,hsa04510,hsa04512,hsa04514,hsa04810,hsa05165,hsa05410,hsa05412,hsa05414 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Cell adhesion molecules (CAMs)|Regulation of actin cytoskeleton|Human papillomavirus infection|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) ITGBL1 233.260921589784 212.07238753028 254.449455649289 1.19982360085873 0.262822315106216 0.236448334709737 1 1.18431 1.47651 1.85528 1.48786 GeneID:9358,Genbank:NM_001271754.1,HGNC:HGNC:6164,MIM:604234 integrin subunit beta like 1 GO:0005615,GO:0005886,GO:0007155 extracellular space|plasma membrane|cell adhesion ITIH2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:3698,Genbank:NM_002216.2,HGNC:HGNC:6167,MIM:146640 inter-alpha-trypsin inhibitor heavy chain 2 GO:0004866,GO:0004867,GO:0005576,GO:0005788,GO:0030212,GO:0043687,GO:0044267,GO:0070062,GO:0072562 endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|endoplasmic reticulum lumen|hyaluronan metabolic process|post-translational protein modification|cellular protein metabolic process|extracellular exosome|blood microparticle ITIH4 9.52242525206825 9.34957425676688 9.69527624736962 1.03697515855896 0.0523813338299616 1 1 0.0457696 0.0101509 0.0427035 0.0498877 GeneID:3700,Genbank:NM_001166449.1,HGNC:HGNC:6169,MIM:600564 inter-alpha-trypsin inhibitor heavy chain family member 4 GO:0002576,GO:0004866,GO:0004867,GO:0005576,GO:0006953,GO:0030212,GO:0031089,GO:0034097,GO:0070062,GO:0072562 platelet degranulation|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|acute-phase response|hyaluronan metabolic process|platelet dense granule lumen|response to cytokine|extracellular exosome|blood microparticle ITK 2.95062884258107 3.47852608838648 2.42273159677566 0.69648222701686 -0.521841556593199 0.840650475727963 1 0.00916121 0.051468 0.00875323 0.0244301 GeneID:3702,Genbank:NM_005546.3,HGNC:HGNC:6171,MIM:186973 IL2 inducible T cell kinase hsa04062,hsa04660,hsa04670 Chemokine signaling pathway|T cell receptor signaling pathway|Leukocyte transendothelial migration ITLN1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0331402 0 GeneID:55600,Genbank:NM_017625.2,HGNC:HGNC:18259,MIM:609873 intelectin 1 GO:0001934,GO:0005509,GO:0005576,GO:0009624,GO:0019730,GO:0031225,GO:0031526,GO:0042802,GO:0043235,GO:0045121,GO:0046326,GO:0070062,GO:0070207,GO:0070492 positive regulation of protein phosphorylation|calcium ion binding|extracellular region|response to nematode|antimicrobial humoral response|anchored component of membrane|brush border membrane|identical protein binding|receptor complex|membrane raft|positive regulation of glucose import|extracellular exosome|protein homotrimerization|oligosaccharide binding ITM2B 10024.318463616 9320.25395530748 10728.3829719245 1.15108268759299 0.20299147264961 0.11809837537467 1 231.17 239.092 283.905 261.222 GeneID:9445,Genbank:NM_021999.4,HGNC:HGNC:6174,MIM:603904 integral membrane protein 2B ITM2C 3551.331143053 3582.0609279521 3520.60135815389 0.982842399659194 -0.0249679982184113 0.837150991088272 1 65.9313 69.2897 64.2086 71.559 GeneID:81618,Genbank:NM_001287241.1,HGNC:HGNC:6175,MIM:609554 integral membrane protein 2C GO:0001540,GO:0005524,GO:0005764,GO:0005765,GO:0005794,GO:0005886,GO:0010977,GO:0016021,GO:0030182,GO:0042985,GO:0048471,GO:0070062,GO:2001238 amyloid-beta binding|ATP binding|lysosome|lysosomal membrane|Golgi apparatus|plasma membrane|negative regulation of neuron projection development|integral component of membrane|neuron differentiation|negative regulation of amyloid precursor protein biosynthetic process|perinuclear region of cytoplasm|extracellular exosome|positive regulation of extrinsic apoptotic signaling pathway ITPA 1108.52013130479 1071.96874681836 1145.07151579121 1.06819486966371 0.0951748603701233 0.597439373298045 1 4.92497 4.8376 5.40658 6.38036 GeneID:3704,Genbank:NM_001324237.1,HGNC:HGNC:6176,MIM:147520 inosine triphosphatase GO:0000166,GO:0005737,GO:0005829,GO:0006193,GO:0006195,GO:0009143,GO:0035529,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0046872,GO:0047429,GO:0051276 nucleotide binding|cytoplasm|cytosol|ITP catabolic process|purine nucleotide catabolic process|nucleoside triphosphate catabolic process|NADH pyrophosphatase activity|dITP diphosphatase activity|ITP diphosphatase activity|XTP diphosphatase activity|identical protein binding|metal ion binding|nucleoside-triphosphate diphosphatase activity|chromosome organization hsa00230,hsa00983 Purine metabolism|Drug metabolism - other enzymes ITPK1 2624.07178595367 2444.09522100292 2804.04835090443 1.14727459339895 0.198210733221666 0.151841598560953 1 17.5896 17.522 20.8258 20.4232 GeneID:3705,Genbank:NM_001142594.2,HGNC:HGNC:6177,MIM:601838 inositol-tetrakisphosphate 1-kinase GO:0000287,GO:0003824,GO:0005524,GO:0005829,GO:0007165,GO:0007596,GO:0016324,GO:0016853,GO:0021915,GO:0032957,GO:0043647,GO:0047325,GO:0052659,GO:0052725,GO:0052726,GO:0052825,GO:0052830,GO:0052831,GO:0052835 magnesium ion binding|catalytic activity|ATP binding|cytosol|signal transduction|blood coagulation|apical plasma membrane|isomerase activity|neural tube development|inositol trisphosphate metabolic process|inositol phosphate metabolic process|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,3,4-trisphosphate 6-kinase activity|inositol-1,3,4-trisphosphate 5-kinase activity|inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity|inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity|inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity|inositol-3,4,6-trisphosphate 1-kinase activity hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system ITPKA 194.093332700877 210.333632986514 177.853032415239 0.845575811580465 -0.241993987102466 0.444749728287082 1 4.24784 5.97722 4.96158 4.55704 GeneID:3706,Genbank:NM_002220.2,HGNC:HGNC:6178,MIM:147521 inositol-trisphosphate 3-kinase A GO:0004683,GO:0005516,GO:0005524,GO:0005829,GO:0006020,GO:0007165,GO:0008440,GO:0030036,GO:0032958,GO:0043197,GO:0043647,GO:0048167,GO:0048365,GO:0061003,GO:0097062 calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|cytosol|inositol metabolic process|signal transduction|inositol-1,4,5-trisphosphate 3-kinase activity|actin cytoskeleton organization|inositol phosphate biosynthetic process|dendritic spine|inositol phosphate metabolic process|regulation of synaptic plasticity|Rac GTPase binding|positive regulation of dendritic spine morphogenesis|dendritic spine maintenance hsa00562,hsa04020,hsa04070 Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system ITPKB 609.379814108308 565.032347793183 653.727280423433 1.15697319450233 0.21035543954779 0.209498711433712 1 1.5031 1.5453 1.70654 1.86687 GeneID:3707,Genbank:NM_002221.3,HGNC:HGNC:6179,MIM:147522 inositol-trisphosphate 3-kinase B GO:0000165,GO:0001932,GO:0002262,GO:0005516,GO:0005524,GO:0005634,GO:0005829,GO:0007165,GO:0007166,GO:0008440,GO:0016020,GO:0032957,GO:0032958,GO:0033030,GO:0035726,GO:0043647,GO:0045059,GO:0045638,GO:0046579,GO:0046638,GO:0071277 MAPK cascade|regulation of protein phosphorylation|myeloid cell homeostasis|calmodulin binding|ATP binding|nucleus|cytosol|signal transduction|cell surface receptor signaling pathway|inositol-1,4,5-trisphosphate 3-kinase activity|membrane|inositol trisphosphate metabolic process|inositol phosphate biosynthetic process|negative regulation of neutrophil apoptotic process|common myeloid progenitor cell proliferation|inositol phosphate metabolic process|positive thymic T cell selection|negative regulation of myeloid cell differentiation|positive regulation of Ras protein signal transduction|positive regulation of alpha-beta T cell differentiation|cellular response to calcium ion hsa00562,hsa04020,hsa04070 Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system ITPKC 421.722158712186 387.917708935292 455.526608489081 1.17428670565042 0.231784689812171 0.198559583846616 1 3.97151 3.61341 4.28745 4.62203 GeneID:80271,Genbank:NM_025194.2,HGNC:HGNC:14897,MIM:606476 inositol-trisphosphate 3-kinase C GO:0005516,GO:0005524,GO:0005829,GO:0008440,GO:0016607,GO:0032958,GO:0043647 calmodulin binding|ATP binding|cytosol|inositol-1,4,5-trisphosphate 3-kinase activity|nuclear speck|inositol phosphate biosynthetic process|inositol phosphate metabolic process hsa00562,hsa04020,hsa04070 Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system ITPR1 516.712085004158 537.117895191829 496.306274816486 0.924017388471543 -0.114008093867652 0.512979961661767 1 1.23431 1.27221 1.33841 1.00963 GeneID:3708,Genbank:NM_001099952.2,HGNC:HGNC:6180,MIM:147265 inositol 1,4,5-trisphosphate receptor type 1 GO:0001666,GO:0005220,GO:0005509,GO:0005637,GO:0005730,GO:0005783,GO:0005789,GO:0005886,GO:0005955,GO:0006816,GO:0007165,GO:0009791,GO:0010506,GO:0014069,GO:0015085,GO:0015278,GO:0016020,GO:0016021,GO:0016529,GO:0019855,GO:0030168,GO:0030658,GO:0031088,GO:0031094,GO:0031095,GO:0032469,GO:0035091,GO:0042045,GO:0043234,GO:0048471,GO:0050796,GO:0050849,GO:0050882,GO:0051209,GO:0070059,GO:0070679,GO:1903779 response to hypoxia|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|calcium ion binding|nuclear inner membrane|nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|calcineurin complex|calcium ion transport|signal transduction|post-embryonic development|regulation of autophagy|postsynaptic density|calcium ion transmembrane transporter activity|calcium-release channel activity|membrane|integral component of membrane|sarcoplasmic reticulum|calcium channel inhibitor activity|platelet activation|transport vesicle membrane|platelet dense granule membrane|platelet dense tubular network|platelet dense tubular network membrane|endoplasmic reticulum calcium ion homeostasis|phosphatidylinositol binding|epithelial fluid transport|protein complex|perinuclear region of cytoplasm|regulation of insulin secretion|negative regulation of calcium-mediated signaling|voluntary musculoskeletal movement|release of sequestered calcium ion into cytosol|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|inositol 1,4,5 trisphosphate binding|regulation of cardiac conduction hsa04020,hsa04022,hsa04070,hsa04114,hsa04140,hsa04210,hsa04218,hsa04270,hsa04371,hsa04540,hsa04611,hsa04621,hsa04625,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04912,hsa04915,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04934,hsa04970,hsa04971,hsa04972,hsa05010,hsa05016,hsa05163,hsa05167,hsa05170,hsa05205 Calcium signaling pathway|cGMP-PKG signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Autophagy - animal|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Huntington disease|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer ITPR2 91.020678333057 87.9903042874068 94.0510523787072 1.06887972646968 0.0960995258481494 0.885681085026819 1 0.188944 0.207749 0.306842 0.141062 GeneID:3709,Genbank:NM_002223.3,HGNC:HGNC:6181,MIM:600144 inositol 1,4,5-trisphosphate receptor type 2 GO:0001666,GO:0005220,GO:0005509,GO:0005634,GO:0005783,GO:0005789,GO:0005886,GO:0005938,GO:0006810,GO:0007165,GO:0015085,GO:0016020,GO:0016021,GO:0030168,GO:0031095,GO:0033017,GO:0035091,GO:0043235,GO:0050796,GO:0051209,GO:0070679,GO:0071320,GO:0071361,GO:0097110,GO:1903779 response to hypoxia|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|calcium ion binding|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|cell cortex|transport|signal transduction|calcium ion transmembrane transporter activity|membrane|integral component of membrane|platelet activation|platelet dense tubular network membrane|sarcoplasmic reticulum membrane|phosphatidylinositol binding|receptor complex|regulation of insulin secretion|release of sequestered calcium ion into cytosol|inositol 1,4,5 trisphosphate binding|cellular response to cAMP|cellular response to ethanol|scaffold protein binding|regulation of cardiac conduction hsa04020,hsa04022,hsa04070,hsa04114,hsa04210,hsa04218,hsa04270,hsa04371,hsa04540,hsa04611,hsa04621,hsa04625,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04912,hsa04915,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04934,hsa04970,hsa04971,hsa04972,hsa05010,hsa05163,hsa05167,hsa05170,hsa05205 Calcium signaling pathway|cGMP-PKG signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer ITPR3 6941.54272440128 6835.97018969494 7047.11525910763 1.0308873595925 0.0438867045439261 0.752573077763707 1 25.0127 25.7296 28.0634 25.5062 GeneID:3710,Genbank:XM_017010832.1,HGNC:HGNC:6182,MIM:147267 inositol 1,4,5-trisphosphate receptor type 3 GO:0000822,GO:0005220,GO:0005509,GO:0005640,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0005903,GO:0007186,GO:0007204,GO:0007613,GO:0015278,GO:0016020,GO:0030168,GO:0031095,GO:0035091,GO:0043025,GO:0043209,GO:0043235,GO:0043533,GO:0045177,GO:0050796,GO:0050913,GO:0050916,GO:0050917,GO:0051260,GO:0051291,GO:0051592,GO:0060291,GO:0060402,GO:0070679,GO:1903779 inositol hexakisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|calcium ion binding|nuclear outer membrane|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|brush border|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|memory|calcium-release channel activity|membrane|platelet activation|platelet dense tubular network membrane|phosphatidylinositol binding|neuronal cell body|myelin sheath|receptor complex|inositol 1,3,4,5 tetrakisphosphate binding|apical part of cell|regulation of insulin secretion|sensory perception of bitter taste|sensory perception of sweet taste|sensory perception of umami taste|protein homooligomerization|protein heterooligomerization|response to calcium ion|long-term synaptic potentiation|calcium ion transport into cytosol|inositol 1,4,5 trisphosphate binding|regulation of cardiac conduction hsa04020,hsa04022,hsa04070,hsa04114,hsa04210,hsa04218,hsa04270,hsa04371,hsa04540,hsa04611,hsa04621,hsa04625,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04742,hsa04750,hsa04911,hsa04912,hsa04915,hsa04918,hsa04921,hsa04922,hsa04924,hsa04925,hsa04927,hsa04928,hsa04934,hsa04970,hsa04971,hsa04972,hsa05010,hsa05163,hsa05167,hsa05170,hsa05205 Calcium signaling pathway|cGMP-PKG signaling pathway|Phosphatidylinositol signaling system|Oocyte meiosis|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Thyroid hormone synthesis|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer ITPRIP 1087.94734705977 1031.12033266737 1144.77436145216 1.11022382663212 0.150850560376738 0.32257429737807 1 5.06502 5.27237 6.40663 5.26386 GeneID:85450,Genbank:NM_001272013.1,HGNC:HGNC:29370 inositol 1,4,5-trisphosphate receptor interacting protein GO:0005886,GO:0016020 plasma membrane|membrane ITPRIPL1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00811375 GeneID:150771,Genbank:NM_001008949.2,HGNC:HGNC:29371 ITPRIP like 1 GO:0016020,GO:0016021 membrane|integral component of membrane ITPRIPL2 603.483335460218 552.616866609978 654.349804310457 1.18409307396743 0.243782486434569 0.348766039195477 1 3.80979 3.60466 5.36681 3.58796 GeneID:162073,Genbank:NM_001034841.3,HGNC:HGNC:27257 ITPRIP like 2 GO:0016021 integral component of membrane ITSN1 387.768707878969 409.125049388405 366.412366369532 0.895599931896803 -0.159073676402243 0.397423579013005 1 0.718473 0.730844 0.726918 0.544173 GeneID:6453,Genbank:NM_001331010.1,HGNC:HGNC:6183,MIM:602442 intersectin 1 GO:0005085,GO:0005089,GO:0005509,GO:0005829,GO:0005886,GO:0005905,GO:0007186,GO:0007264,GO:0016032,GO:0019209,GO:0030027,GO:0030054,GO:0030139,GO:0032947,GO:0035023,GO:0043005,GO:0043065,GO:0043524,GO:0045202,GO:0048013,GO:0048488,GO:0051056,GO:0051897,GO:0061024,GO:0070064 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|calcium ion binding|cytosol|plasma membrane|clathrin-coated pit|G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|viral process|kinase activator activity|lamellipodium|cell junction|endocytic vesicle|protein complex scaffold activity|regulation of Rho protein signal transduction|neuron projection|positive regulation of apoptotic process|negative regulation of neuron apoptotic process|synapse|ephrin receptor signaling pathway|synaptic vesicle endocytosis|regulation of small GTPase mediated signal transduction|positive regulation of protein kinase B signaling|membrane organization|proline-rich region binding ITSN2 215.834380447964 231.00185876213 200.666902133797 0.868680898106669 -0.203101781212961 0.365864852358662 1 0.55323 0.594733 0.661529 0.418408 GeneID:50618,Genbank:XM_024452935.1,HGNC:HGNC:6184,MIM:604464 intersectin 2 GO:0005070,GO:0005089,GO:0005509,GO:0005737,GO:0005813,GO:0006897,GO:0035023,GO:0070062,GO:1903861 SH3/SH2 adaptor activity|Rho guanyl-nucleotide exchange factor activity|calcium ion binding|cytoplasm|centrosome|endocytosis|regulation of Rho protein signal transduction|extracellular exosome|positive regulation of dendrite extension IVD 1863.90230315786 1999.66744736508 1728.13715895064 0.864212277510328 -0.210542368035803 0.130828946618726 1 11.529 12.1987 10.4062 10.6762 GeneID:3712,Genbank:NM_001354600.1,HGNC:HGNC:6186,MIM:607036 isovaleryl-CoA dehydrogenase GO:0005759,GO:0006552,GO:0008470,GO:0009083,GO:0033539,GO:0050660 mitochondrial matrix|leucine catabolic process|isovaleryl-CoA dehydrogenase activity|branched-chain amino acid catabolic process|fatty acid beta-oxidation using acyl-CoA dehydrogenase|flavin adenine dinucleotide binding hsa00280 Valine, leucine and isoleucine degradation IVNS1ABP 1812.93493220953 1901.46883652826 1724.4010278908 0.906878406190052 -0.141018967007203 0.332752757495615 1 7.34151 7.0617 7.02722 5.92683 GeneID:10625,Genbank:XM_011509080.3,HGNC:HGNC:16951,MIM:609209 influenza virus NS1A binding protein GO:0005654,GO:0005667,GO:0005681,GO:0005829,GO:0006383,GO:0008380,GO:0009615,GO:0015629,GO:0016032,GO:2001243 nucleoplasm|transcription factor complex|spliceosomal complex|cytosol|transcription from RNA polymerase III promoter|RNA splicing|response to virus|actin cytoskeleton|viral process|negative regulation of intrinsic apoptotic signaling pathway hsa05164 Influenza A IWS1 1104.1582338155 1151.79930806016 1056.51715957084 0.917275390059238 -0.124573161256458 0.41966779830596 1 6.67512 6.4876 6.36915 5.88706 GeneID:55677,Genbank:XM_006712626.3,HGNC:HGNC:25467 IWS1, SUPT6H interacting protein GO:0005634,GO:0005654,GO:0006366,GO:0006368,GO:0006397,GO:0008380,GO:0010793,GO:0032784,GO:0050684,GO:0051028,GO:0090239,GO:2001253 nucleus|nucleoplasm|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|mRNA processing|RNA splicing|regulation of mRNA export from nucleus|regulation of DNA-templated transcription, elongation|regulation of mRNA processing|mRNA transport|regulation of histone H4 acetylation|regulation of histone H3-K36 trimethylation IZUMO1 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0 0 0 0 GeneID:284359,Genbank:NM_001321864.1,HGNC:HGNC:28539,MIM:609278 izumo sperm-egg fusion 1 GO:0005102,GO:0005886,GO:0007155,GO:0007338,GO:0007342,GO:0016021,GO:0034113,GO:0035036,GO:0042802,GO:0042803,GO:0086080 receptor binding|plasma membrane|cell adhesion|single fertilization|fusion of sperm to egg plasma membrane involved in single fertilization|integral component of membrane|heterotypic cell-cell adhesion|sperm-egg recognition|identical protein binding|protein homodimerization activity|protein binding involved in heterotypic cell-cell adhesion IZUMO1R 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.064766 0 0 GeneID:390243,Genbank:NM_001199206.1,HGNC:HGNC:32565,MIM:615737 IZUMO1 receptor, JUNO GO:0004872,GO:0005576,GO:0005886,GO:0006501,GO:0007155,GO:0007338,GO:0007342,GO:0031225,GO:0035036 receptor activity|extracellular region|plasma membrane|C-terminal protein lipidation|cell adhesion|single fertilization|fusion of sperm to egg plasma membrane involved in single fertilization|anchored component of membrane|sperm-egg recognition hsa01523,hsa04144 Antifolate resistance|Endocytosis IZUMO4 13.6451807246339 10.819788462639 16.4705729866289 1.5222638634297 0.606218451789722 0.508921732558753 1 0.176199 0.186782 0.0405846 0.378268 GeneID:113177,Genbank:XM_024451342.1,HGNC:HGNC:26950 IZUMO family member 4 GO:0005576,GO:0005634 extracellular region|nucleus JADE1 704.717281376524 752.71683508518 656.717727667868 0.872463185433539 -0.196833838422396 0.221185693846746 1 3.12533 3.42505 3.19208 2.60719 GeneID:79960,Genbank:NM_199320.3,HGNC:HGNC:30027,MIM:610514 jade family PHD finger 1 GO:0000123,GO:0001105,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0006950,GO:0030308,GO:0036064,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0046872,GO:0090090,GO:2000134 histone acetyltransferase complex|RNA polymerase II transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|apoptotic process|response to stress|negative regulation of cell growth|ciliary basal body|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|metal ion binding|negative regulation of canonical Wnt signaling pathway|negative regulation of G1/S transition of mitotic cell cycle JADE2 6206.50974247523 5831.0921816692 6581.92730328127 1.12876406309823 0.174743962134212 0.191492185271914 1 29.0441 30.3369 35.9562 32.1058 GeneID:23338,Genbank:XM_011543291.3,HGNC:HGNC:22984,MIM:610515 jade family PHD finger 2 GO:0000123,GO:0005654,GO:0016567,GO:0016740,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0046872,GO:0070062 histone acetyltransferase complex|nucleoplasm|protein ubiquitination|transferase activity|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|metal ion binding|extracellular exosome JADE3 195.396853288611 196.928200344287 193.865506232936 0.984447661096806 -0.0226135886927795 0.931973293684409 1 1.41973 1.48905 1.60052 1.28551 GeneID:9767,Genbank:NM_001077445.2,HGNC:HGNC:22982,MIM:300618 jade family PHD finger 3 GO:0000123,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0046872 histone acetyltransferase complex|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|metal ion binding JAG1 1268.02105254819 1237.15695889415 1298.88514620223 1.04989519467543 0.0702453186831947 0.628266197010666 1 8.31522 8.09986 9.61137 7.9016 GeneID:182,Genbank:NM_000214.2,HGNC:HGNC:6188,MIM:601920 jagged 1 hsa01522,hsa04330,hsa04371,hsa04658,hsa04668,hsa05165,hsa05200,hsa05224 Endocrine resistance|Notch signaling pathway|Apelin signaling pathway|Th1 and Th2 cell differentiation|TNF signaling pathway|Human papillomavirus infection|Pathways in cancer|Breast cancer JAG2 50.671046417785 61.603900821718 39.7381920138519 0.645059671283712 -0.632495471586805 0.110570342796989 1 0.504542 0.642714 0.345783 0.341743 GeneID:3714,Genbank:NM_145159.2,HGNC:HGNC:6189,MIM:602570 jagged 2 hsa01522,hsa04330,hsa04658,hsa05200,hsa05224 Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Pathways in cancer|Breast cancer JAGN1 1081.1210218098 1082.51120328885 1079.73084033075 0.997431561955527 -0.00371023963219377 0.94812801712817 1 32.2939 39.7689 36.6351 35.8507 GeneID:84522,Genbank:NM_032492.3,HGNC:HGNC:26926,MIM:616012 jagunal homolog 1 GO:0002446,GO:0005783,GO:0005789,GO:0006887,GO:0007029,GO:0015031,GO:0016021,GO:0016192,GO:0030223,GO:0038158,GO:0050832,GO:0061179,GO:1904577,GO:1990266 neutrophil mediated immunity|endoplasmic reticulum|endoplasmic reticulum membrane|exocytosis|endoplasmic reticulum organization|protein transport|integral component of membrane|vesicle-mediated transport|neutrophil differentiation|granulocyte colony-stimulating factor signaling pathway|defense response to fungus|negative regulation of insulin secretion involved in cellular response to glucose stimulus|cellular response to tunicamycin|neutrophil migration JAK1 2289.67664390107 2237.84483836548 2341.50844943667 1.04632296631741 0.0653282339810715 0.706295215336354 1 13.1124 12.6261 15.8375 11.783 GeneID:3716,Genbank:NM_001321852.1,HGNC:HGNC:6190,MIM:147795 Janus kinase 1 hsa01521,hsa04151,hsa04217,hsa04380,hsa04550,hsa04621,hsa04630,hsa04658,hsa04659,hsa05140,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05200,hsa05203,hsa05212 EGFR tyrosine kinase inhibitor resistance|PI3K-Akt signaling pathway|Necroptosis|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|NOD-like receptor signaling pathway|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Leishmaniasis|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer JAK2 83.2946354162562 81.753646230908 84.8356246016043 1.03769835980149 0.0533871392052983 0.917681827961489 1 0.574097 0.420091 0.75032 0.37781 GeneID:3717,Genbank:NM_001322194.1,HGNC:HGNC:6192,MIM:147796 Janus kinase 2 hsa01521,hsa04062,hsa04151,hsa04217,hsa04550,hsa04630,hsa04658,hsa04659,hsa04725,hsa04917,hsa04920,hsa04933,hsa05140,hsa05145,hsa05152,hsa05162,hsa05164,hsa05167,hsa05168,hsa05200 EGFR tyrosine kinase inhibitor resistance|Chemokine signaling pathway|PI3K-Akt signaling pathway|Necroptosis|Signaling pathways regulating pluripotency of stem cells|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Cholinergic synapse|Prolactin signaling pathway|Adipocytokine signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis|Toxoplasmosis|Tuberculosis|Measles|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Pathways in cancer JAK3 6.50138857509147 6.21704074628294 6.7857364039 1.0914736899476 0.126277354479315 0.978494224114163 1 0.0281451 0.0311381 0.0263372 0.0368454 GeneID:3718,Genbank:XM_005259896.3,HGNC:HGNC:6193,MIM:600173 Janus kinase 3 hsa04062,hsa04151,hsa04217,hsa04550,hsa04630,hsa04658,hsa04659,hsa05162,hsa05166,hsa05169,hsa05200,hsa05203,hsa05223,hsa05340 Chemokine signaling pathway|PI3K-Akt signaling pathway|Necroptosis|Signaling pathways regulating pluripotency of stem cells|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Measles|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Non-small cell lung cancer|Primary immunodeficiency JAKMIP2 196.689492602607 170.916198420969 222.462786784244 1.30158983665384 0.38027489101371 0.093399662919894 0.989999339063549 0.59281 0.524372 0.82193 0.671551 GeneID:9832,Genbank:NM_001282282.1,HGNC:HGNC:29067,MIM:611197 janus kinase and microtubule interacting protein 2 GO:0005794,GO:0008017,GO:0019900 Golgi apparatus|microtubule binding|kinase binding JAKMIP3 86.6219887252959 79.2268539819672 94.0171234686247 1.18668252925989 0.246934025356716 0.45281683529204 1 0.225419 0.227116 0.260439 0.272884 GeneID:282973,Genbank:XM_011539676.2,HGNC:HGNC:23523,MIM:611198 Janus kinase and microtubule interacting protein 3 GO:0005794,GO:0008017,GO:0019900 Golgi apparatus|microtubule binding|kinase binding JAM2 185.753662588894 177.633119224318 193.87420595347 1.09143051025661 0.126220279023548 0.594032339201488 1 1.28495 1.19599 1.5205 1.13805 GeneID:58494,Genbank:XM_024452124.1,HGNC:HGNC:14686,MIM:606870 junctional adhesion molecule 2 GO:0005886,GO:0005887,GO:0005923,GO:0007162,GO:0030198,GO:0046982,GO:0050900,GO:0098609 plasma membrane|integral component of plasma membrane|bicellular tight junction|negative regulation of cell adhesion|extracellular matrix organization|protein heterodimerization activity|leukocyte migration|cell-cell adhesion hsa04514,hsa04530,hsa04670,hsa05120 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Epithelial cell signaling in Helicobacter pylori infection JAM3 1409.37434736229 1313.4149754999 1505.33371922467 1.14612193960383 0.196760545231791 0.176877738548156 1 15.5281 15.7354 19.5939 16.6009 GeneID:83700,Genbank:NM_032801.4,HGNC:HGNC:15532,MIM:606871 junctional adhesion molecule 3 GO:0001525,GO:0001780,GO:0002250,GO:0002318,GO:0002523,GO:0005178,GO:0005615,GO:0005794,GO:0005886,GO:0005923,GO:0007160,GO:0007286,GO:0016021,GO:0019226,GO:0030010,GO:0030057,GO:0030198,GO:0031103,GO:0033010,GO:0042552,GO:0042803,GO:0043220,GO:0044291,GO:0046982,GO:0050900,GO:0090022,GO:0090138 angiogenesis|neutrophil homeostasis|adaptive immune response|myeloid progenitor cell differentiation|leukocyte migration involved in inflammatory response|integrin binding|extracellular space|Golgi apparatus|plasma membrane|bicellular tight junction|cell-matrix adhesion|spermatid development|integral component of membrane|transmission of nerve impulse|establishment of cell polarity|desmosome|extracellular matrix organization|axon regeneration|paranodal junction|myelination|protein homodimerization activity|Schmidt-Lanterman incisure|cell-cell contact zone|protein heterodimerization activity|leukocyte migration|regulation of neutrophil chemotaxis|regulation of actin cytoskeleton organization by cell-cell adhesion hsa04514,hsa04530,hsa04670,hsa05120 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Epithelial cell signaling in Helicobacter pylori infection JARID2 1030.84318341845 975.099322365926 1086.58704447098 1.11433473447048 0.156182668244639 0.307623538678455 1 4.70901 4.89972 5.89676 4.94833 GeneID:3720,Genbank:NM_004973.3,HGNC:HGNC:6196,MIM:601594 jumonji and AT-rich interaction domain containing 2 GO:0000977,GO:0001227,GO:0001889,GO:0003682,GO:0005634,GO:0005654,GO:0005739,GO:0006351,GO:0007417,GO:0008134,GO:0010614,GO:0016569,GO:0031061,GO:0035097,GO:0035098,GO:0045814,GO:0045892,GO:0048536,GO:0048538,GO:0048863,GO:0051574,GO:0060044,GO:1990830 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|liver development|chromatin binding|nucleus|nucleoplasm|mitochondrion|transcription, DNA-templated|central nervous system development|transcription factor binding|negative regulation of cardiac muscle hypertrophy|covalent chromatin modification|negative regulation of histone methylation|histone methyltransferase complex|ESC/E(Z) complex|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|spleen development|thymus development|stem cell differentiation|positive regulation of histone H3-K9 methylation|negative regulation of cardiac muscle cell proliferation|cellular response to leukemia inhibitory factor hsa04550 Signaling pathways regulating pluripotency of stem cells JAZF1 265.145724871732 301.051626275855 229.23982346761 0.761463494827818 -0.393153220477192 0.0614652179321565 0.886147929923425 4.44401 3.85594 3.48196 3.04371 GeneID:221895,Genbank:NM_175061.3,HGNC:HGNC:28917,MIM:606246 JAZF zinc finger 1 JCAD 37.3896156009283 42.7890824485985 31.9901487532581 0.747624088263334 -0.419615041777807 0.38423949144792 1 0.173326 0.136608 0.148241 0.104803 GeneID:57608,Genbank:NM_001350021.1,HGNC:HGNC:29283,MIM:614398 junctional cadherin 5 associated GO:0005911,GO:0005912,GO:0007155,GO:0032587,GO:0043410,GO:0048471,GO:0090050,GO:1900748,GO:1903589 cell-cell junction|adherens junction|cell adhesion|ruffle membrane|positive regulation of MAPK cascade|perinuclear region of cytoplasm|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of vascular endothelial growth factor signaling pathway|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis JCHAIN 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0313217 0 0 GeneID:3512,Genbank:NM_144646.3,HGNC:HGNC:5713,MIM:147790 joining chain of multimeric IgA and IgM GO:0001895,GO:0002250,GO:0003094,GO:0003823,GO:0005576,GO:0005615,GO:0006898,GO:0006955,GO:0019731,GO:0019862,GO:0030674,GO:0032461,GO:0034987,GO:0042803,GO:0045087,GO:0050900,GO:0060267,GO:0070062,GO:0071748,GO:0071750,GO:0071751,GO:0071752,GO:0071756,GO:0072562 retina homeostasis|adaptive immune response|glomerular filtration|antigen binding|extracellular region|extracellular space|receptor-mediated endocytosis|immune response|antibacterial humoral response|IgA binding|protein binding, bridging|positive regulation of protein oligomerization|immunoglobulin receptor binding|protein homodimerization activity|innate immune response|leukocyte migration|positive regulation of respiratory burst|extracellular exosome|monomeric IgA immunoglobulin complex|dimeric IgA immunoglobulin complex|secretory IgA immunoglobulin complex|secretory dimeric IgA immunoglobulin complex|pentameric IgM immunoglobulin complex|blood microparticle JDP2 187.133241350066 179.93939741005 194.327085290082 1.07995851985235 0.110975900951198 0.645268889603932 1 0.577604 0.58444 0.643703 0.71564 GeneID:122953,Genbank:XM_017020975.2,HGNC:HGNC:17546,MIM:608657 Jun dimerization protein 2 GO:0000978,GO:0001078,GO:0003682,GO:0005634,GO:0006351,GO:0031065,GO:0045599,GO:0046982 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|chromatin binding|nucleus|transcription, DNA-templated|positive regulation of histone deacetylation|negative regulation of fat cell differentiation|protein heterodimerization activity JHY 99.3788112640002 105.229047250176 93.5285752778239 0.888809484851314 -0.170053882486481 0.564768285232475 1 0.314376 0.375824 0.309918 0.314866 GeneID:79864,Genbank:XM_017018341.1,HGNC:HGNC:26288,MIM:617594 junctional cadherin complex regulator GO:0007420,GO:0032053,GO:0033326,GO:0035082 brain development|ciliary basal body organization|cerebrospinal fluid secretion|axoneme assembly JKAMP 879.123850685254 926.658688811301 831.589012559206 0.897405940935979 -0.156167360025651 0.331546413749727 1 16.3286 15.0919 14.174 14.6522 GeneID:51528,Genbank:NM_001284201.1,HGNC:HGNC:20184,MIM:611176 JNK1/MAPK8 associated membrane protein GO:0005789,GO:0006986,GO:0016021,GO:0030433,GO:0031625 endoplasmic reticulum membrane|response to unfolded protein|integral component of membrane|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding JMJD1C 137.33099785369 132.124122427184 142.537873280196 1.07881793772179 0.109451414864806 0.871052045344065 1 0.414264 0.286059 0.551651 0.196001 GeneID:221037,Genbank:NM_001322258.1,HGNC:HGNC:12313,MIM:604503 jumonji domain containing 1C GO:0000785,GO:0000976,GO:0005622,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0007596,GO:0031490,GO:0032454,GO:0033169,GO:0046872,GO:0046966,GO:0051213 chromatin|transcription regulatory region sequence-specific DNA binding|intracellular|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|blood coagulation|chromatin DNA binding|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|metal ion binding|thyroid hormone receptor binding|dioxygenase activity hsa05202 Transcriptional misregulation in cancer JMJD4 547.89592126489 522.512822683333 573.279019846448 1.09715780160649 0.133771040073352 0.452507396088523 1 8.13445 9.03307 8.97275 10.1207 GeneID:65094,Genbank:NM_001161465.1,HGNC:HGNC:25724 jumonji domain containing 4 JMJD6 782.273388983298 822.0746174431 742.472160523497 0.903168817975197 -0.14693241715678 0.358309629171552 1 5.11713 5.08219 4.86254 4.45835 GeneID:23210,Genbank:NM_001081461.1,HGNC:HGNC:19355,MIM:604914 arginine demethylase and lysine hydroxylase GO:0002040,GO:0003727,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0006355,GO:0006397,GO:0008380,GO:0018395,GO:0030154,GO:0033746,GO:0033749,GO:0046872,GO:0048024,GO:0070815 sprouting angiogenesis|single-stranded RNA binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA processing|RNA splicing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|cell differentiation|histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|metal ion binding|regulation of mRNA splicing, via spliceosome|peptidyl-lysine 5-dioxygenase activity JMJD7 85.5268235727498 94.4955026817994 76.5581444637001 0.810177651750254 -0.303689805165111 0.348048302713759 1 7.43959 8.57764 7.39089 7.79128 GeneID:100137047,Genbank:NM_001114632.1,HGNC:HGNC:34397 jumonji domain containing 7 JMJD8 1412.12886085268 1343.7808021119 1480.47691959346 1.10172501145033 0.139764174795039 0.348492934972063 1 21.6064 22.6098 25.2662 26.372 GeneID:339123,Genbank:NM_001323922.1,HGNC:HGNC:14148 jumonji domain containing 8 GO:0070062 extracellular exosome JMY 237.824965061786 251.709319158179 223.940610965394 0.889679459284008 -0.168642450715712 0.553626070361544 1 1.16596 1.12736 1.26288 0.768475 GeneID:133746,Genbank:NM_152405.4,HGNC:HGNC:28916,MIM:604279 junction mediating and regulatory protein, p53 cofactor GO:0003713,GO:0003779,GO:0005634,GO:0005654,GO:0005737,GO:0005856,GO:0006281,GO:0006357,GO:0007050,GO:0031252,GO:0034314,GO:0043065,GO:0051091,GO:0070060,GO:0070358,GO:0071933,GO:0072332,GO:1901796 transcription coactivator activity|actin binding|nucleus|nucleoplasm|cytoplasm|cytoskeleton|DNA repair|regulation of transcription from RNA polymerase II promoter|cell cycle arrest|cell leading edge|Arp2/3 complex-mediated actin nucleation|positive regulation of apoptotic process|positive regulation of DNA binding transcription factor activity|'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex binding|intrinsic apoptotic signaling pathway by p53 class mediator|regulation of signal transduction by p53 class mediator JOSD1 2204.22493496399 2160.76056643497 2247.68930349301 1.04023061990689 0.0569034103969239 0.674424693684158 1 15.1083 14.4432 15.8992 15.527 GeneID:9929,Genbank:XM_005261878.3,HGNC:HGNC:28953,MIM:615323 Josephin domain containing 1 GO:0004843,GO:0005829,GO:0005886,GO:0016020,GO:0016579,GO:0036459 thiol-dependent ubiquitin-specific protease activity|cytosol|plasma membrane|membrane|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity JOSD2 574.864174754217 499.845076679455 649.883272828978 1.30016939877901 0.378699603912896 0.0272272995373549 0.661718405751558 14.1738 14.6405 19.7605 18.3999 GeneID:126119,Genbank:NM_001270640.1,HGNC:HGNC:28853,MIM:615324 Josephin domain containing 2 GO:0004843,GO:0005829,GO:0016579,GO:0036459 thiol-dependent ubiquitin-specific protease activity|cytosol|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity JPH1 93.6571830246649 98.1279162493487 89.1864497999811 0.908879483116234 -0.137839088298029 0.651351375824608 1 0.864115 0.908321 1.01802 0.626632 GeneID:56704,Genbank:XM_005251274.3,HGNC:HGNC:14201,MIM:605266 junctophilin 1 GO:0005634,GO:0005654,GO:0005886,GO:0007517,GO:0008307,GO:0014701,GO:0016021,GO:0030018,GO:0030314,GO:0060314,GO:0060402 nucleus|nucleoplasm|plasma membrane|muscle organ development|structural constituent of muscle|junctional sarcoplasmic reticulum membrane|integral component of membrane|Z disc|junctional membrane complex|regulation of ryanodine-sensitive calcium-release channel activity|calcium ion transport into cytosol JPH2 424.558548974183 338.297052824614 510.820045123751 1.50997486043303 0.594524530324846 0.0011545926569437 0.112072460567335 1.88359 1.97428 3.23241 2.72787 GeneID:57158,Genbank:NM_020433.4,HGNC:HGNC:14202,MIM:605267 junctophilin 2 GO:0001786,GO:0005546,GO:0005547,GO:0005886,GO:0010314,GO:0014701,GO:0015278,GO:0016021,GO:0030018,GO:0030314,GO:0032266,GO:0055024,GO:0055074,GO:0060314,GO:0060316,GO:0060402,GO:0070273,GO:0070300,GO:0080025 phosphatidylserine binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|plasma membrane|phosphatidylinositol-5-phosphate binding|junctional sarcoplasmic reticulum membrane|calcium-release channel activity|integral component of membrane|Z disc|junctional membrane complex|phosphatidylinositol-3-phosphate binding|regulation of cardiac muscle tissue development|calcium ion homeostasis|regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of ryanodine-sensitive calcium-release channel activity|calcium ion transport into cytosol|phosphatidylinositol-4-phosphate binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding JPH3 1.50692932373655 1.07619535328461 1.93766329418849 1.80047543252685 0.848377914099981 0.867062907276331 1 0.0225799 0 0.0103831 0 GeneID:57338,Genbank:NM_020655.3,HGNC:HGNC:14203,MIM:605268 junctophilin 3 GO:0005886,GO:0007612,GO:0007613,GO:0014701,GO:0015278,GO:0016021,GO:0030314,GO:0035640,GO:0040011,GO:0048168,GO:0050885,GO:0060314,GO:0060402 plasma membrane|learning|memory|junctional sarcoplasmic reticulum membrane|calcium-release channel activity|integral component of membrane|junctional membrane complex|exploration behavior|locomotion|regulation of neuronal synaptic plasticity|neuromuscular process controlling balance|regulation of ryanodine-sensitive calcium-release channel activity|calcium ion transport into cytosol JPH4 5.96916396987275 6.12098819691306 5.81733974283245 0.950392249696913 -0.0734050236575849 1 1 0.0603322 0.0736774 0.0893213 0.0419472 GeneID:84502,Genbank:NM_001146028.1,HGNC:HGNC:20156 junctophilin 4 GO:0001817,GO:0005790,GO:0005886,GO:0007612,GO:0014701,GO:0016021,GO:0030314,GO:0043198,GO:0048167,GO:0050885,GO:0060314,GO:0060402,GO:2001256 regulation of cytokine production|smooth endoplasmic reticulum|plasma membrane|learning|junctional sarcoplasmic reticulum membrane|integral component of membrane|junctional membrane complex|dendritic shaft|regulation of synaptic plasticity|neuromuscular process controlling balance|regulation of ryanodine-sensitive calcium-release channel activity|calcium ion transport into cytosol|regulation of store-operated calcium entry JPT1 3984.02522226082 4123.52959683005 3844.5208476916 0.932337396255641 -0.101075959944134 0.447280936161635 1 28.6337 28.3625 27.7243 26.5574 GeneID:51155,Genbank:NM_001002032.2,HGNC:HGNC:14569 Jupiter microtubule associated homolog 1 GO:0005634,GO:0005730,GO:0005737,GO:0031965 nucleus|nucleolus|cytoplasm|nuclear membrane JPT2 3260.37790819264 3453.5563594348 3067.19945695047 0.888127813108122 -0.171160780847824 0.205116080618372 1 39.0471 40.6258 36.5571 35.1302 GeneID:90861,Genbank:NM_144570.2,HGNC:HGNC:14137 Jupiter microtubule associated homolog 2 GO:0005634,GO:0005829,GO:0005886 nucleus|cytosol|plasma membrane JRK 523.832968744473 506.302248799163 541.363688689782 1.06925001809448 0.0965992316283869 0.597192662513184 1 1.73311 1.92932 2.1702 1.81355 GeneID:8629,Genbank:XM_011517355.2,HGNC:HGNC:6199,MIM:603210 Jrk helix-turn-helix protein GO:0003677,GO:0005634,GO:0090263 DNA binding|nucleus|positive regulation of canonical Wnt signaling pathway JRKL 82.9892854653699 81.6575936815381 84.3209772492016 1.03261648363103 0.0463045331004843 0.877732424704008 1 1.0268 0.807965 0.931497 0.989993 GeneID:8690,Genbank:NM_003772.3,HGNC:HGNC:6200,MIM:603211 JRK like GO:0003677,GO:0005634,GO:0007417 DNA binding|nucleus|central nervous system development JSRP1 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0 0 0.0549344 0 GeneID:126306,Genbank:NM_144616.3,HGNC:HGNC:24963,MIM:608743 junctional sarcoplasmic reticulum protein 1 GO:0003009,GO:0016529,GO:0033017,GO:0060314 skeletal muscle contraction|sarcoplasmic reticulum|sarcoplasmic reticulum membrane|regulation of ryanodine-sensitive calcium-release channel activity JTB 2875.41699788265 2976.86335950949 2773.97063625581 0.93184345441804 -0.101840486042569 0.435996230725675 1 84.0819 94.7838 82.5614 83.4941 GeneID:10899,Genbank:NM_006694.3,HGNC:HGNC:6201,MIM:604671 jumping translocation breakpoint GO:0000278,GO:0000281,GO:0005737,GO:0005739,GO:0005815,GO:0005819,GO:0005887,GO:0008637,GO:0016020,GO:0019901,GO:0030496,GO:0042127,GO:0045860 mitotic cell cycle|mitotic cytokinesis|cytoplasm|mitochondrion|microtubule organizing center|spindle|integral component of plasma membrane|apoptotic mitochondrial changes|membrane|protein kinase binding|midbody|regulation of cell proliferation|positive regulation of protein kinase activity JUN 6600.65919956104 6204.87730618944 6996.44109293263 1.12757122303669 0.173218564191575 0.197306919894565 1 95.1182 102.52 112.488 112.971 GeneID:3725,Genbank:NM_002228.3,HGNC:HGNC:6204,MIM:165160 Jun proto-oncogene, AP-1 transcription factor subunit hsa01522,hsa04010,hsa04012,hsa04024,hsa04137,hsa04210,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04912,hsa04915,hsa04921,hsa04926,hsa04932,hsa04933,hsa05030,hsa05031,hsa05120,hsa05132,hsa05133,hsa05140,hsa05142,hsa05161,hsa05164,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05210,hsa05211,hsa05224,hsa05231,hsa05321,hsa05323,hsa05418 Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|cAMP signaling pathway|Mitophagy - animal|Apoptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Cocaine addiction|Amphetamine addiction|Epithelial cell signaling in Helicobacter pylori infection|Salmonella infection|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Hepatitis B|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Colorectal cancer|Renal cell carcinoma|Breast cancer|Choline metabolism in cancer|Inflammatory bowel disease (IBD)|Rheumatoid arthritis|Fluid shear stress and atherosclerosis JUNB 721.66641713176 821.613972006466 621.718862257053 0.756704344667791 -0.4021983664049 0.0122638431472691 0.452575372918575 23.3493 22.5443 16.1802 19.2453 GeneID:3726,Genbank:NM_002229.2,HGNC:HGNC:6205,MIM:165161 JunB proto-oncogene, AP-1 transcription factor subunit hsa04380,hsa04668 Osteoclast differentiation|TNF signaling pathway JUND 3121.31880602335 3085.426854024 3157.21075802271 1.02326546938071 0.0331804771207389 0.836147739845533 1 120.188 126.405 125.399 132.213 GeneID:3727,Genbank:NM_005354.5,HGNC:HGNC:6206,MIM:165162 JunD proto-oncogene, AP-1 transcription factor subunit hsa04010,hsa04380,hsa04657,hsa04928 MAPK signaling pathway|Osteoclast differentiation|IL-17 signaling pathway|Parathyroid hormone synthesis, secretion and action JUP 1064.6783376454 973.591907541332 1155.76476774946 1.18711418901189 0.247458715095843 0.144899920273021 1 8.01574 8.84592 9.49599 10.6632 GeneID:3728,Genbank:NM_001352774.1,HGNC:HGNC:6207,MIM:173325 junction plakoglobin GO:0001533,GO:0002159,GO:0003713,GO:0004871,GO:0005198,GO:0005199,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005882,GO:0005886,GO:0005911,GO:0005913,GO:0005915,GO:0005916,GO:0005925,GO:0007016,GO:0009898,GO:0014704,GO:0015629,GO:0016327,GO:0016328,GO:0016342,GO:0016477,GO:0019901,GO:0019903,GO:0030018,GO:0030057,GO:0031012,GO:0031424,GO:0032993,GO:0034332,GO:0034333,GO:0035580,GO:0042127,GO:0042307,GO:0042803,GO:0043312,GO:0045294,GO:0045296,GO:0050839,GO:0050982,GO:0051091,GO:0051291,GO:0070062,GO:0070268,GO:0071603,GO:0071665,GO:0071681,GO:0072659,GO:0086073,GO:0086083,GO:0086091,GO:0090263,GO:0098609,GO:0098911,GO:1904813 cornified envelope|desmosome assembly|transcription coactivator activity|signal transducer activity|structural molecule activity|structural constituent of cell wall|extracellular region|nucleus|cytoplasm|cytosol|cytoskeleton|intermediate filament|plasma membrane|cell-cell junction|cell-cell adherens junction|zonula adherens|fascia adherens|focal adhesion|cytoskeletal anchoring at plasma membrane|cytoplasmic side of plasma membrane|intercalated disc|actin cytoskeleton|apicolateral plasma membrane|lateral plasma membrane|catenin complex|cell migration|protein kinase binding|protein phosphatase binding|Z disc|desmosome|extracellular matrix|keratinization|protein-DNA complex|adherens junction organization|adherens junction assembly|specific granule lumen|regulation of cell proliferation|positive regulation of protein import into nucleus|protein homodimerization activity|neutrophil degranulation|alpha-catenin binding|cadherin binding|cell adhesion molecule binding|detection of mechanical stimulus|positive regulation of DNA binding transcription factor activity|protein heterooligomerization|extracellular exosome|cornification|endothelial cell-cell adhesion|gamma-catenin-TCF7L2 complex|cellular response to indole-3-methanol|protein localization to plasma membrane|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|positive regulation of canonical Wnt signaling pathway|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential|ficolin-1-rich granule lumen hsa05200,hsa05202,hsa05221,hsa05226,hsa05412 Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy (ARVC) KAAG1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0330133 0 GeneID:353219,Genbank:NM_181337.3,HGNC:HGNC:21031,MIM:608211 kidney associated antigen 1 GO:0001764,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005929,GO:0005930,GO:0006968,GO:0007605,GO:0015630,GO:0019894,GO:0030111,GO:0035556,GO:0045880,GO:0060091,GO:0060271,GO:0072686,GO:1902017 neuron migration|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|cilium|axoneme|cellular defense response|sensory perception of sound|microtubule cytoskeleton|kinesin binding|regulation of Wnt signaling pathway|intracellular signal transduction|positive regulation of smoothened signaling pathway|kinocilium|cilium assembly|mitotic spindle|regulation of cilium assembly KALRN 41.3765344830927 40.5886654673444 42.1644034988411 1.03882211975569 0.0549486389230272 0.926352816716409 1 0.060632 0.0602398 0.0712894 0.0627717 GeneID:8997,Genbank:XM_006713815.3,HGNC:HGNC:4814,MIM:604605 kalirin RhoGEF kinase GO:0001662,GO:0004674,GO:0005085,GO:0005089,GO:0005096,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0007165,GO:0007186,GO:0007266,GO:0007399,GO:0007528,GO:0007595,GO:0007613,GO:0008344,GO:0009612,GO:0014069,GO:0014909,GO:0015629,GO:0016192,GO:0030676,GO:0035023,GO:0035176,GO:0035556,GO:0042711,GO:0043065,GO:0046872,GO:0046959,GO:0048013,GO:0048148,GO:0048168,GO:0048659,GO:0051056,GO:0051966,GO:0060125,GO:0060137,GO:0061003,GO:0061368,GO:0070062,GO:1900273,GO:1903076 behavioral fear response|protein serine/threonine kinase activity|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|ATP binding|nucleoplasm|cytosol|protein phosphorylation|signal transduction|G-protein coupled receptor signaling pathway|Rho protein signal transduction|nervous system development|neuromuscular junction development|lactation|memory|adult locomotory behavior|response to mechanical stimulus|postsynaptic density|smooth muscle cell migration|actin cytoskeleton|vesicle-mediated transport|Rac guanyl-nucleotide exchange factor activity|regulation of Rho protein signal transduction|social behavior|intracellular signal transduction|maternal behavior|positive regulation of apoptotic process|metal ion binding|habituation|ephrin receptor signaling pathway|behavioral response to cocaine|regulation of neuronal synaptic plasticity|smooth muscle cell proliferation|regulation of small GTPase mediated signal transduction|regulation of synaptic transmission, glutamatergic|negative regulation of growth hormone secretion|maternal process involved in parturition|positive regulation of dendritic spine morphogenesis|behavioral response to formalin induced pain|extracellular exosome|positive regulation of long-term synaptic potentiation|regulation of protein localization to plasma membrane KANK1 1705.33074624775 1876.49684634036 1534.16464615513 0.817568464954863 -0.290588544808796 0.0938644105296534 0.992100325879928 6.02511 6.12935 4.45313 5.50657 GeneID:23189,Genbank:NM_001256876.2,HGNC:HGNC:19309,MIM:607704 KN motif and ankyrin repeat domains 1 GO:0005634,GO:0005737,GO:0005886,GO:0006351,GO:0006355,GO:0008013,GO:0010977,GO:0030177,GO:0030336,GO:0030837,GO:0032587,GO:0035024,GO:0035413,GO:0046627,GO:0090303,GO:1900025,GO:1900028,GO:2000114,GO:2000393 nucleus|cytoplasm|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|beta-catenin binding|negative regulation of neuron projection development|positive regulation of Wnt signaling pathway|negative regulation of cell migration|negative regulation of actin filament polymerization|ruffle membrane|negative regulation of Rho protein signal transduction|positive regulation of catenin import into nucleus|negative regulation of insulin receptor signaling pathway|positive regulation of wound healing|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of ruffle assembly|regulation of establishment of cell polarity|negative regulation of lamellipodium morphogenesis KANK2 3090.27576410484 3035.50314660583 3145.04838160384 1.03608799915774 0.051146542172028 0.703861551874345 1 20.6443 19.2575 20.0417 21.8264 GeneID:25959,Genbank:NM_001136191.2,HGNC:HGNC:29300,MIM:614610 KN motif and ankyrin repeat domains 2 GO:0000122,GO:0005737,GO:0005739,GO:0006351,GO:0006915,GO:0008285,GO:0033147,GO:0043069,GO:0070563,GO:2000134 negative regulation of transcription from RNA polymerase II promoter|cytoplasm|mitochondrion|transcription, DNA-templated|apoptotic process|negative regulation of cell proliferation|negative regulation of intracellular estrogen receptor signaling pathway|negative regulation of programmed cell death|negative regulation of vitamin D receptor signaling pathway|negative regulation of G1/S transition of mitotic cell cycle KANK3 5.45377447249282 5.09281911831339 5.81472982667226 1.1417507065513 0.191247682501671 0.966909067508129 1 0.0177357 0.0448774 0.0812906 0.0303693 GeneID:256949,Genbank:NM_198471.2,HGNC:HGNC:24796,MIM:614611 KN motif and ankyrin repeat domains 3 KANSL1 741.269145858443 794.795332068613 687.742959648273 0.865308252199072 -0.208713933584898 0.186577448053911 1 2.54772 2.94311 2.55235 2.14979 GeneID:284058,Genbank:XM_017024488.2,HGNC:HGNC:24565,MIM:612452 KAT8 regulatory NSL complex subunit 1 GO:0000123,GO:0000777,GO:0005634,GO:0005654,GO:0043981,GO:0043982,GO:0043984,GO:0071339 histone acetyltransferase complex|condensed chromosome kinetochore|nucleus|nucleoplasm|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|MLL1 complex KANSL1L 58.8586350473757 66.340918707021 51.3763513877304 0.77442930229263 -0.368794553596545 0.336789525072997 1 0.19028 0.175097 0.150811 0.121641 GeneID:151050,Genbank:NM_001307976.1,HGNC:HGNC:26310,MIM:613833 KAT8 regulatory NSL complex subunit 1 like GO:0000123 histone acetyltransferase complex KANSL2 607.530774629913 644.681629592207 570.379919667619 0.884746661741258 -0.176663681693673 0.293945444243306 1 9.05155 8.76657 7.63708 8.26033 GeneID:54934,Genbank:NM_017822.3,HGNC:HGNC:26024,MIM:615488 KAT8 regulatory NSL complex subunit 2 GO:0000123,GO:0005654,GO:0005829,GO:0005886,GO:0015629,GO:0043981,GO:0043982,GO:0043984 histone acetyltransferase complex|nucleoplasm|cytosol|plasma membrane|actin cytoskeleton|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation KANSL3 2163.20853556991 2151.91392323784 2174.50314790198 1.0104972714848 0.015065426199918 0.937633139833632 1 10.9234 12.1591 11.9243 11.7928 GeneID:55683,Genbank:NM_001349262.1,HGNC:HGNC:25473,MIM:617742 KAT8 regulatory NSL complex subunit 3 GO:0000123,GO:0005634,GO:0005654,GO:0005730,GO:0043231,GO:0043981,GO:0043982,GO:0043984 histone acetyltransferase complex|nucleus|nucleoplasm|nucleolus|intracellular membrane-bounded organelle|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation KARS 3517.90586093848 3431.72467741078 3604.08704446619 1.05022616417628 0.0707000429394877 0.605569886423085 1 41.9604 42.6901 44.3436 43.6916 GeneID:3735,Genbank:NM_005548.2,HGNC:HGNC:6215,MIM:601421 lysyl-tRNA synthetase GO:0000049,GO:0000187,GO:0002276,GO:0002741,GO:0003877,GO:0004824,GO:0005524,GO:0005615,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006418,GO:0006430,GO:0008033,GO:0008285,GO:0010165,GO:0010759,GO:0015966,GO:0016032,GO:0016597,GO:0017101,GO:0033209,GO:0042802,GO:0042803,GO:0043032,GO:0045893,GO:0070371,GO:0070374,GO:1900017,GO:1900745,GO:1905050 tRNA binding|activation of MAPK activity|basophil activation involved in immune response|positive regulation of cytokine secretion involved in immune response|ATP adenylyltransferase activity|lysine-tRNA ligase activity|ATP binding|extracellular space|nucleus|mitochondrion|mitochondrial matrix|cytosol|plasma membrane|tRNA aminoacylation for protein translation|lysyl-tRNA aminoacylation|tRNA processing|negative regulation of cell proliferation|response to X-ray|positive regulation of macrophage chemotaxis|diadenosine tetraphosphate biosynthetic process|viral process|amino acid binding|aminoacyl-tRNA synthetase multienzyme complex|tumor necrosis factor-mediated signaling pathway|identical protein binding|protein homodimerization activity|positive regulation of macrophage activation|positive regulation of transcription, DNA-templated|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of cytokine production involved in inflammatory response|positive regulation of p38MAPK cascade|positive regulation of metallopeptidase activity hsa00970 Aminoacyl-tRNA biosynthesis KAT14 351.977970501675 353.104039086958 350.851901916393 0.993621887825502 -0.00923114082423207 0.982388743182098 1 3.9448 3.56997 3.6535 3.96877 GeneID:57325,Genbank:NM_020536.4,HGNC:HGNC:15904,MIM:617501 lysine acetyltransferase 14 GO:0000086,GO:0004402,GO:0005634,GO:0005671,GO:0005737,GO:0030274,GO:0043966 G2/M transition of mitotic cell cycle|histone acetyltransferase activity|nucleus|Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|LIM domain binding|histone H3 acetylation KAT2A 1174.46091863402 1196.39682263913 1152.52501462891 0.963330053055938 -0.053897920570968 0.704832327913086 1 11.4143 11.3689 12.1594 10.4714 GeneID:2648,Genbank:NM_021078.2,HGNC:HGNC:4201,MIM:602301 lysine acetyltransferase 2A GO:0000790,GO:0001701,GO:0001756,GO:0001843,GO:0003682,GO:0003713,GO:0004402,GO:0005615,GO:0005634,GO:0005654,GO:0005671,GO:0006338,GO:0006357,GO:0006366,GO:0008134,GO:0008283,GO:0010484,GO:0014070,GO:0016032,GO:0016578,GO:0016579,GO:0019903,GO:0021537,GO:0022037,GO:0030901,GO:0030914,GO:0031346,GO:0031647,GO:0031667,GO:0033276,GO:0035066,GO:0035264,GO:0035948,GO:0036459,GO:0042826,GO:0043966,GO:0043997,GO:0044154,GO:0045815,GO:0048312,GO:0055007,GO:0071356,GO:0071929,GO:0072686,GO:1903146,GO:1903955,GO:1990090,GO:2000679 nuclear chromatin|in utero embryonic development|somitogenesis|neural tube closure|chromatin binding|transcription coactivator activity|histone acetyltransferase activity|extracellular space|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription factor binding|cell proliferation|H3 histone acetyltransferase activity|response to organic cyclic compound|viral process|histone deubiquitination|protein deubiquitination|protein phosphatase binding|telencephalon development|metencephalon development|midbrain development|STAGA complex|positive regulation of cell projection organization|regulation of protein stability|response to nutrient levels|transcription factor TFTC complex|positive regulation of histone acetylation|multicellular organism growth|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|thiol-dependent ubiquitinyl hydrolase activity|histone deacetylase binding|histone H3 acetylation|histone acetyltransferase activity (H4-K12 specific)|histone H3-K14 acetylation|positive regulation of gene expression, epigenetic|intracellular distribution of mitochondria|cardiac muscle cell differentiation|cellular response to tumor necrosis factor|alpha-tubulin acetylation|mitotic spindle|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|cellular response to nerve growth factor stimulus|positive regulation of transcription regulatory region DNA binding hsa04330,hsa04919,hsa05166,hsa05203 Notch signaling pathway|Thyroid hormone signaling pathway|Human T-cell leukemia virus 1 infection|Viral carcinogenesis KAT2B 1165.00900308624 1151.7982910593 1178.21971511318 1.02293928047903 0.0327205122859699 0.818445355192612 1 8.7213 7.71746 9.32651 7.59337 GeneID:8850,Genbank:NM_003884.4,HGNC:HGNC:8638,MIM:602303 lysine acetyltransferase 2B GO:0000125,GO:0000776,GO:0000977,GO:0003682,GO:0003712,GO:0003713,GO:0004402,GO:0004468,GO:0004861,GO:0005634,GO:0005654,GO:0005671,GO:0006338,GO:0006367,GO:0006473,GO:0007050,GO:0007219,GO:0007221,GO:0008134,GO:0008285,GO:0010835,GO:0016032,GO:0016407,GO:0016579,GO:0018076,GO:0018393,GO:0018394,GO:0019901,GO:0031672,GO:0031674,GO:0032403,GO:0032869,GO:0035948,GO:0042641,GO:0042826,GO:0043234,GO:0043966,GO:0043970,GO:0045652,GO:0045736,GO:0045747,GO:0045815,GO:0045944,GO:0048511 PCAF complex|kinetochore|RNA polymerase II regulatory region sequence-specific DNA binding|chromatin binding|transcription cofactor activity|transcription coactivator activity|histone acetyltransferase activity|lysine N-acetyltransferase activity, acting on acetyl phosphate as donor|cyclin-dependent protein serine/threonine kinase inhibitor activity|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling|transcription initiation from RNA polymerase II promoter|protein acetylation|cell cycle arrest|Notch signaling pathway|positive regulation of transcription of Notch receptor target|transcription factor binding|negative regulation of cell proliferation|regulation of protein ADP-ribosylation|viral process|acetyltransferase activity|protein deubiquitination|N-terminal peptidyl-lysine acetylation|internal peptidyl-lysine acetylation|peptidyl-lysine acetylation|protein kinase binding|A band|I band|protein complex binding|cellular response to insulin stimulus|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|actomyosin|histone deacetylase binding|protein complex|histone H3 acetylation|histone H3-K9 acetylation|regulation of megakaryocyte differentiation|negative regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of Notch signaling pathway|positive regulation of gene expression, epigenetic|positive regulation of transcription from RNA polymerase II promoter|rhythmic process hsa04330,hsa04919,hsa05166,hsa05203 Notch signaling pathway|Thyroid hormone signaling pathway|Human T-cell leukemia virus 1 infection|Viral carcinogenesis KAT5 1288.33694168101 1303.62437311672 1273.04951024531 0.976546263247361 -0.0342397024122166 0.804925208991072 1 14.278 15.0081 13.8186 15.305 GeneID:10524,Genbank:NM_182710.2,HGNC:HGNC:5275,MIM:601409 lysine acetyltransferase 5 GO:0000812,GO:0003713,GO:0004402,GO:0005730,GO:0006351,GO:0006978,GO:0032777,GO:0035267,GO:0040008,GO:0045893,GO:0046872,GO:0048471 Swr1 complex|transcription coactivator activity|histone acetyltransferase activity|nucleolus|transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|Piccolo NuA4 histone acetyltransferase complex|NuA4 histone acetyltransferase complex|regulation of growth|positive regulation of transcription, DNA-templated|metal ion binding|perinuclear region of cytoplasm hsa05166 Human T-cell leukemia virus 1 infection KAT6A 1199.70268704851 1105.76202224149 1293.64335185554 1.16991117965255 0.226399003707035 0.308144610622052 1 3.50185 3.30311 4.7401 3.33051 GeneID:7994,Genbank:NM_006766.4,HGNC:HGNC:13013,MIM:601408 lysine acetyltransferase 6A hsa04550 Signaling pathways regulating pluripotency of stem cells KAT6B 380.046730858207 396.103826943657 363.989634772756 0.918924812166813 -0.121981272058222 0.661948601694584 1 1.44649 1.10569 1.3522 1.03028 GeneID:23522,Genbank:XM_005269664.2,HGNC:HGNC:17582,MIM:605880 lysine acetyltransferase 6B GO:0000786,GO:0003677,GO:0004402,GO:0006334,GO:0006351,GO:0008134,GO:0016407,GO:0016573,GO:0043966,GO:0045892,GO:0045893,GO:0046872,GO:0070776 nucleosome|DNA binding|histone acetyltransferase activity|nucleosome assembly|transcription, DNA-templated|transcription factor binding|acetyltransferase activity|histone acetylation|histone H3 acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|MOZ/MORF histone acetyltransferase complex KAT7 1246.67550931247 1235.19769028717 1258.15332833776 1.0185845862821 0.0265657909494654 0.867167421585833 1 11.0168 12.1793 13.0154 11.4015 GeneID:11143,Genbank:NM_007067.4,HGNC:HGNC:17016,MIM:609880 lysine acetyltransferase 7 GO:0000123,GO:0003688,GO:0003700,GO:0004402,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006351,GO:0008270,GO:0031098,GO:0043966,GO:0043981,GO:0043982,GO:0043983,GO:0044212,GO:0045944,GO:0072708,GO:0072710,GO:0072716,GO:0072720,GO:0072739,GO:0090240,GO:1900182 histone acetyltransferase complex|DNA replication origin binding|DNA binding transcription factor activity|histone acetyltransferase activity|nucleus|nucleoplasm|cytosol|DNA replication|transcription, DNA-templated|zinc ion binding|stress-activated protein kinase signaling cascade|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|response to sorbitol|response to hydroxyurea|response to actinomycin D|response to dithiothreitol|response to anisomycin|positive regulation of histone H4 acetylation|positive regulation of protein localization to nucleus KAT8 476.963848780821 461.610715672528 492.316981889114 1.06651982974843 0.0929107898826655 0.756457126869756 1 4.64261 5.02049 4.58162 6.16751 GeneID:84148,Genbank:NM_182958.2,HGNC:HGNC:17933,MIM:609912 lysine acetyltransferase 8 GO:0000123,GO:0000776,GO:0004402,GO:0005634,GO:0005654,GO:0006351,GO:0008134,GO:0010506,GO:0016407,GO:0016573,GO:0019899,GO:0030099,GO:0035064,GO:0043981,GO:0043982,GO:0043984,GO:0045892,GO:0045893,GO:0046872,GO:0071339,GO:0072487 histone acetyltransferase complex|kinetochore|histone acetyltransferase activity|nucleus|nucleoplasm|transcription, DNA-templated|transcription factor binding|regulation of autophagy|acetyltransferase activity|histone acetylation|enzyme binding|myeloid cell differentiation|methylated histone binding|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|MLL1 complex|MSL complex KATNA1 361.076341462001 371.764969980915 350.387712943087 0.942497925399144 -0.0854386521237372 0.663266456782515 1 4.81134 4.61733 4.19698 4.36604 GeneID:11104,Genbank:XM_017010209.1,HGNC:HGNC:6216,MIM:606696 katanin catalytic subunit A1 GO:0000922,GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005819,GO:0005874,GO:0007049,GO:0008017,GO:0008568,GO:0030496,GO:0046982,GO:0051301,GO:0097431 spindle pole|ATP binding|nucleus|cytoplasm|microtubule organizing center|spindle|microtubule|cell cycle|microtubule binding|microtubule-severing ATPase activity|midbody|protein heterodimerization activity|cell division|mitotic spindle pole KATNAL1 426.643939654532 484.459741119183 368.82813818988 0.761318447922682 -0.393428057531 0.0316083421199592 0.705068533973909 1.80443 1.64391 1.43996 1.1347 GeneID:84056,Genbank:XM_017020791.2,HGNC:HGNC:28361,MIM:614764 katanin catalytic subunit A1 like 1 GO:0000922,GO:0005524,GO:0005634,GO:0005737,GO:0005819,GO:0005874,GO:0007283,GO:0008017,GO:0008568,GO:0042802,GO:0051013 spindle pole|ATP binding|nucleus|cytoplasm|spindle|microtubule|spermatogenesis|microtubule binding|microtubule-severing ATPase activity|identical protein binding|microtubule severing KATNAL2 33.61238231319 33.7855007697342 33.4392638566458 0.989751908209142 -0.014861151160697 1 1 0.0673518 0.0635579 0.0773226 0.119979 GeneID:83473,Genbank:XM_006722554.4,HGNC:HGNC:25387,MIM:614697 katanin catalytic subunit A1 like 2 GO:0000922,GO:0005524,GO:0005634,GO:0005737,GO:0005819,GO:0005874,GO:0008568 spindle pole|ATP binding|nucleus|cytoplasm|spindle|microtubule|microtubule-severing ATPase activity KATNB1 1229.57777417079 1346.48008214936 1112.67546619223 0.826358652417704 -0.275160025394306 0.0629310965088442 0.894325147902084 10.703 10.2756 8.55723 9.11026 GeneID:10300,Genbank:XM_006721121.4,HGNC:HGNC:6217,MIM:602703 katanin regulatory subunit B1 GO:0000922,GO:0005634,GO:0005737,GO:0005813,GO:0005819,GO:0005829,GO:0005874,GO:0005886,GO:0006605,GO:0007026,GO:0007049,GO:0008017,GO:0008352,GO:0010942,GO:0010976,GO:0015630,GO:0016020,GO:0030424,GO:0030426,GO:0030496,GO:0031117,GO:0043025,GO:0046982,GO:0051013,GO:0051301,GO:0070840 spindle pole|nucleus|cytoplasm|centrosome|spindle|cytosol|microtubule|plasma membrane|protein targeting|negative regulation of microtubule depolymerization|cell cycle|microtubule binding|katanin complex|positive regulation of cell death|positive regulation of neuron projection development|microtubule cytoskeleton|membrane|axon|growth cone|midbody|positive regulation of microtubule depolymerization|neuronal cell body|protein heterodimerization activity|microtubule severing|cell division|dynein complex binding KATNBL1 553.429802326314 575.688440121551 531.171164531078 0.922671235883989 -0.116111413269441 0.504474829843499 1 3.70796 3.69854 3.69353 2.99086 GeneID:79768,Genbank:NM_024713.2,HGNC:HGNC:26199,MIM:616235 katanin regulatory subunit B1 like 1 GO:0005634,GO:0005730,GO:0005737,GO:0051495,GO:0097431 nucleus|nucleolus|cytoplasm|positive regulation of cytoskeleton organization|mitotic spindle pole KAZALD1 243.111835195031 231.29001641024 254.933653979823 1.10222506762958 0.140418843509356 0.507466900271205 1 2.78047 2.44113 3.00795 2.5128 GeneID:81621,Genbank:XM_024448213.1,HGNC:HGNC:25460,MIM:609208 Kazal type serine peptidase inhibitor domain 1 GO:0001503,GO:0001558,GO:0005520,GO:0005614,GO:0007275,GO:0030154,GO:0030198 ossification|regulation of cell growth|insulin-like growth factor binding|interstitial matrix|multicellular organism development|cell differentiation|extracellular matrix organization KAZN 106.864220590072 103.220735367662 110.507705812482 1.07059599429188 0.0984141598335021 0.763197298510691 1 0.203089 0.240062 0.253035 0.206332 GeneID:23254,Genbank:XM_011541074.3,HGNC:HGNC:29173 kazrin, periplakin interacting protein GO:0001533,GO:0005654,GO:0005829,GO:0005856,GO:0016607,GO:0030057,GO:0070268 cornified envelope|nucleoplasm|cytosol|cytoskeleton|nuclear speck|desmosome|cornification KBTBD11 4.02725918189237 5.6309167949557 2.42360156882906 0.430409764001516 -1.21621728856163 0.465455424831644 1 0.0271245 0.0369142 0.019204 0.0119318 GeneID:9920,Genbank:XM_011534771.2,HGNC:HGNC:29104 kelch repeat and BTB domain containing 11 GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KBTBD12 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00372739 0 0 GeneID:166348,Genbank:XM_011512490.2,HGNC:HGNC:25731 kelch repeat and BTB domain containing 12 GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KBTBD2 1494.65891899572 1581.92876714698 1407.38907084446 0.889666526124753 -0.16866342314589 0.257912435151258 1 17.4477 15.757 15.6168 14.1054 GeneID:25948,Genbank:NM_015483.2,HGNC:HGNC:21751 kelch repeat and BTB domain containing 2 GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KBTBD3 43.3925917685926 50.4381197811765 36.3470637560087 0.720626857497836 -0.472675673407307 0.269183737582063 1 0.182315 0.257821 0.127159 0.133853 GeneID:143879,Genbank:XM_006718767.3,HGNC:HGNC:22934 kelch repeat and BTB domain containing 3 GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KBTBD4 862.698642092421 887.012965529149 838.384318655693 0.945177073207215 -0.0813434600438759 0.602287051808388 1 12.2288 12.0293 11.7026 11.7768 GeneID:55709,Genbank:NM_001318721.1,HGNC:HGNC:23761,MIM:617645 kelch repeat and BTB domain containing 4 GO:0005634,GO:0005737,GO:0019005,GO:0030162,GO:0031625,GO:0042787,GO:0043161 nucleus|cytoplasm|SCF ubiquitin ligase complex|regulation of proteolysis|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process KBTBD6 277.858120505226 326.967575649802 228.748665360649 0.699606573850767 -0.515384249285112 0.0119456726555114 0.445971779139093 2.88286 2.90665 2.14514 1.9627 GeneID:89890,Genbank:NM_152903.4,HGNC:HGNC:25340,MIM:617738 kelch repeat and BTB domain containing 6 GO:0005829,GO:0016567,GO:0031463,GO:0043687 cytosol|protein ubiquitination|Cul3-RING ubiquitin ligase complex|post-translational protein modification KBTBD7 114.952884394272 129.107258776286 100.798510012258 0.780734646275151 -0.357095802028645 0.211167931375823 1 1.36301 1.26266 1.01152 1.05617 GeneID:84078,Genbank:NM_032138.6,HGNC:HGNC:25266,MIM:617739 kelch repeat and BTB domain containing 7 GO:0000165,GO:0005829,GO:0016567,GO:0031463,GO:0043687 MAPK cascade|cytosol|protein ubiquitination|Cul3-RING ubiquitin ligase complex|post-translational protein modification KBTBD8 25.3876228702641 31.8732414365897 18.9020043039385 0.593036774798796 -0.753806524391247 0.186088763754507 1 0.301309 0.246474 0.198094 0.140218 GeneID:84541,Genbank:NM_032505.2,HGNC:HGNC:30691,MIM:616607 kelch repeat and BTB domain containing 8 GO:0005794,GO:0005819,GO:0005829,GO:0006417,GO:0006513,GO:0014029,GO:0014032,GO:0031463,GO:0042787,GO:0043687 Golgi apparatus|spindle|cytosol|regulation of translation|protein monoubiquitination|neural crest formation|neural crest cell development|Cul3-RING ubiquitin ligase complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|post-translational protein modification KCMF1 1240.70104179155 1153.95271576758 1327.44936781551 1.15034987974574 0.202072724650742 0.173343431594892 1 5.03448 5.58143 6.44779 5.60889 GeneID:56888,Genbank:NM_020122.4,HGNC:HGNC:20589,MIM:614719 potassium channel modulatory factor 1 KCNA2 3.41851291692417 0.538097676642304 6.29892815720603 11.705919632493 3.54916637381573 0.0865239474226127 0.964561165794104 0 0 0.015852 0.0236693 GeneID:3737,Genbank:XM_011541398.2,HGNC:HGNC:6220,MIM:176262 potassium voltage-gated channel subfamily A member 2 GO:0005249,GO:0005251,GO:0005267,GO:0005789,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0014059,GO:0015271,GO:0019228,GO:0019233,GO:0019894,GO:0021633,GO:0030027,GO:0030424,GO:0030425,GO:0031258,GO:0032809,GO:0033010,GO:0034765,GO:0042734,GO:0043204,GO:0043679,GO:0044224,GO:0045188,GO:0051260,GO:0071805 voltage-gated potassium channel activity|delayed rectifier potassium channel activity|potassium channel activity|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|regulation of dopamine secretion|outward rectifier potassium channel activity|neuronal action potential|sensory perception of pain|kinesin binding|optic nerve structural organization|lamellipodium|axon|dendrite|lamellipodium membrane|neuronal cell body membrane|paranodal junction|regulation of ion transmembrane transport|presynaptic membrane|perikaryon|axon terminus|juxtaparanode region of axon|regulation of circadian sleep/wake cycle, non-REM sleep|protein homooligomerization|potassium ion transmembrane transport KCNA6 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00461892 0 GeneID:3742,Genbank:XM_017019271.1,HGNC:HGNC:6225,MIM:176257 potassium voltage-gated channel subfamily A member 6 GO:0005249,GO:0005251,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0030424,GO:0034705,GO:0034765,GO:0043679,GO:0051260,GO:0071805 voltage-gated potassium channel activity|delayed rectifier potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|axon|potassium channel complex|regulation of ion transmembrane transport|axon terminus|protein homooligomerization|potassium ion transmembrane transport KCNA7 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00976623 0 GeneID:3743,Genbank:NM_031886.2,HGNC:HGNC:6226,MIM:176268 potassium voltage-gated channel subfamily A member 7 GO:0005249,GO:0005886,GO:0008076,GO:0016021,GO:0034765,GO:0051260,GO:0071805 voltage-gated potassium channel activity|plasma membrane|voltage-gated potassium channel complex|integral component of membrane|regulation of ion transmembrane transport|protein homooligomerization|potassium ion transmembrane transport KCNAB1 111.200234928894 131.30767575754 91.0927941002473 0.693735484804792 -0.527542414078473 0.0857832858109072 0.964561165794104 0.31858 0.304309 0.171553 0.26439 GeneID:7881,Genbank:XM_017007171.2,HGNC:HGNC:6228,MIM:601141 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 GO:0004033,GO:0005249,GO:0005829,GO:0005886,GO:0006813,GO:0007420,GO:0007507,GO:0007519,GO:0007611,GO:0008076,GO:0015459,GO:0019904,GO:0031234,GO:0032839,GO:0034705,GO:0043204,GO:0044224,GO:0044325,GO:0045445,GO:0055114,GO:0060539,GO:0070402,GO:1901379,GO:1902259,GO:1902260,GO:1903817,GO:1990635 aldo-keto reductase (NADP) activity|voltage-gated potassium channel activity|cytosol|plasma membrane|potassium ion transport|brain development|heart development|skeletal muscle tissue development|learning or memory|voltage-gated potassium channel complex|potassium channel regulator activity|protein domain specific binding|extrinsic component of cytoplasmic side of plasma membrane|dendrite cytoplasm|potassium channel complex|perikaryon|juxtaparanode region of axon|ion channel binding|myoblast differentiation|oxidation-reduction process|diaphragm development|NADPH binding|regulation of potassium ion transmembrane transport|regulation of delayed rectifier potassium channel activity|negative regulation of delayed rectifier potassium channel activity|negative regulation of voltage-gated potassium channel activity|proximal dendrite KCNAB2 481.903528766999 442.81449760877 520.992559925228 1.17654810928419 0.23456031385305 0.182433333255758 1 2.55948 2.33591 2.88361 2.52743 GeneID:8514,Genbank:NM_001199861.1,HGNC:HGNC:6229,MIM:601142 potassium voltage-gated channel subfamily A regulatory beta subunit 2 GO:0002244,GO:0004033,GO:0005249,GO:0005829,GO:0005856,GO:0005886,GO:0008076,GO:0014069,GO:0015459,GO:0016020,GO:0030054,GO:0031234,GO:0035579,GO:0043312,GO:0043679,GO:0044224,GO:0050905,GO:0055114,GO:0070821,GO:0070995,GO:1901379,GO:1990031,GO:2000008 hematopoietic progenitor cell differentiation|aldo-keto reductase (NADP) activity|voltage-gated potassium channel activity|cytosol|cytoskeleton|plasma membrane|voltage-gated potassium channel complex|postsynaptic density|potassium channel regulator activity|membrane|cell junction|extrinsic component of cytoplasmic side of plasma membrane|specific granule membrane|neutrophil degranulation|axon terminus|juxtaparanode region of axon|neuromuscular process|oxidation-reduction process|tertiary granule membrane|NADPH oxidation|regulation of potassium ion transmembrane transport|pinceau fiber|regulation of protein localization to cell surface KCNAB3 65.1081091790204 59.9317728619982 70.2844454960426 1.17274097093512 0.229884393404964 0.537724218707708 1 0.733027 0.664896 1.0565 0.56259 GeneID:9196,Genbank:NM_004732.3,HGNC:HGNC:6230,MIM:604111 potassium voltage-gated channel subfamily A regulatory beta subunit 3 GO:0005249,GO:0005737,GO:0005886,GO:0006813,GO:0015459,GO:0016021,GO:0034765 voltage-gated potassium channel activity|cytoplasm|plasma membrane|potassium ion transport|potassium channel regulator activity|integral component of membrane|regulation of ion transmembrane transport KCNB1 4.42321221068316 2.05633815719933 6.79008626416698 3.30202804455803 1.72335237330174 0.485034875320457 1 0.00659208 0.00609809 0.0406566 0.00291641 GeneID:3745,Genbank:NM_004975.3,HGNC:HGNC:6231,MIM:600397 potassium voltage-gated channel subfamily B member 1 GO:0001508,GO:0005251,GO:0005886,GO:0006904,GO:0007215,GO:0008076,GO:0010701,GO:0016328,GO:0030054,GO:0030424,GO:0030425,GO:0031669,GO:0032809,GO:0033605,GO:0034765,GO:0042383,GO:0042593,GO:0043204,GO:0044325,GO:0045211,GO:0045956,GO:0046676,GO:0046982,GO:0050796,GO:0051260,GO:0071333,GO:0071805,GO:0072659,GO:0090314,GO:0098900,GO:1900454,GO:2000671 action potential|delayed rectifier potassium channel activity|plasma membrane|vesicle docking involved in exocytosis|glutamate receptor signaling pathway|voltage-gated potassium channel complex|positive regulation of norepinephrine secretion|lateral plasma membrane|cell junction|axon|dendrite|cellular response to nutrient levels|neuronal cell body membrane|positive regulation of catecholamine secretion|regulation of ion transmembrane transport|sarcolemma|glucose homeostasis|perikaryon|ion channel binding|postsynaptic membrane|positive regulation of calcium ion-dependent exocytosis|negative regulation of insulin secretion|protein heterodimerization activity|regulation of insulin secretion|protein homooligomerization|cellular response to glucose stimulus|potassium ion transmembrane transport|protein localization to plasma membrane|positive regulation of protein targeting to membrane|regulation of action potential|positive regulation of long term synaptic depression|regulation of motor neuron apoptotic process KCNB2 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.00668898 0 0 0 GeneID:9312,Genbank:NM_004770.2,HGNC:HGNC:6232,MIM:607738 potassium voltage-gated channel subfamily B member 2 GO:0005249,GO:0005251,GO:0005886,GO:0006813,GO:0006940,GO:0008076,GO:0016021,GO:0030425,GO:0032809,GO:0034765,GO:0043204,GO:0046982,GO:0051260,GO:0071805,GO:0072659 voltage-gated potassium channel activity|delayed rectifier potassium channel activity|plasma membrane|potassium ion transport|regulation of smooth muscle contraction|voltage-gated potassium channel complex|integral component of membrane|dendrite|neuronal cell body membrane|regulation of ion transmembrane transport|perikaryon|protein heterodimerization activity|protein homooligomerization|potassium ion transmembrane transport|protein localization to plasma membrane KCNC1 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.0150533 0 0 GeneID:3746,Genbank:NM_001112741.1,HGNC:HGNC:6233,MIM:176258 potassium voltage-gated channel subfamily C member 1 GO:0005251,GO:0007420,GO:0008076,GO:0009636,GO:0009642,GO:0009986,GO:0010996,GO:0014075,GO:0016020,GO:0019894,GO:0021549,GO:0021759,GO:0030425,GO:0030673,GO:0032589,GO:0032590,GO:0032809,GO:0034765,GO:0034767,GO:0035690,GO:0035864,GO:0043025,GO:0044325,GO:0051260,GO:0051262,GO:0071774,GO:0071805,GO:1901379,GO:1901381,GO:1903818,GO:1990089 delayed rectifier potassium channel activity|brain development|voltage-gated potassium channel complex|response to toxic substance|response to light intensity|cell surface|response to auditory stimulus|response to amine|membrane|kinesin binding|cerebellum development|globus pallidus development|dendrite|axolemma|neuron projection membrane|dendrite membrane|neuronal cell body membrane|regulation of ion transmembrane transport|positive regulation of ion transmembrane transport|cellular response to drug|response to potassium ion|neuronal cell body|ion channel binding|protein homooligomerization|protein tetramerization|response to fibroblast growth factor|potassium ion transmembrane transport|regulation of potassium ion transmembrane transport|positive regulation of potassium ion transmembrane transport|positive regulation of voltage-gated potassium channel activity|response to nerve growth factor KCNC3 20.2060021915111 13.7602168743831 26.651787508639 1.93687263448991 0.953729087843499 0.139692032438449 1 0.19054 0.189371 0.362576 0.388375 GeneID:3748,Genbank:NM_004977.2,HGNC:HGNC:6235,MIM:176264 potassium voltage-gated channel subfamily C member 3 GO:0005249,GO:0005856,GO:0005886,GO:0005938,GO:0008076,GO:0030054,GO:0030424,GO:0032591,GO:0034765,GO:0042734,GO:0043204,GO:0051260,GO:0051262,GO:0071805 voltage-gated potassium channel activity|cytoskeleton|plasma membrane|cell cortex|voltage-gated potassium channel complex|cell junction|axon|dendritic spine membrane|regulation of ion transmembrane transport|presynaptic membrane|perikaryon|protein homooligomerization|protein tetramerization|potassium ion transmembrane transport KCNC4 17.3661214830537 17.767031984304 16.9652109818034 0.954870289916236 -0.0666233248846144 1 1 0.195588 0.0565733 0.163691 0.0969553 GeneID:3749,Genbank:NM_004978.4,HGNC:HGNC:6236,MIM:176265 potassium voltage-gated channel subfamily C member 4 GO:0005249,GO:0005267,GO:0005886,GO:0006813,GO:0007268,GO:0008076,GO:0016021,GO:0031594,GO:0034765,GO:0043679,GO:0046928,GO:0051260 voltage-gated potassium channel activity|potassium channel activity|plasma membrane|potassium ion transport|chemical synaptic transmission|voltage-gated potassium channel complex|integral component of membrane|neuromuscular junction|regulation of ion transmembrane transport|axon terminus|regulation of neurotransmitter secretion|protein homooligomerization KCND1 59.0745797608054 70.1752460284179 47.973913493193 0.683630143224089 -0.54871208388684 0.135168936426452 1 0.36051 0.528 0.294166 0.34816 GeneID:3750,Genbank:XM_024452378.1,HGNC:HGNC:6237,MIM:300281 potassium voltage-gated channel subfamily D member 1 GO:0005250,GO:0005886,GO:0008076,GO:0016021,GO:0030425,GO:0034765,GO:0043025,GO:0046872,GO:0051260,GO:0061337 A-type (transient outward) potassium channel activity|plasma membrane|voltage-gated potassium channel complex|integral component of membrane|dendrite|regulation of ion transmembrane transport|neuronal cell body|metal ion binding|protein homooligomerization|cardiac conduction KCND2 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.00906933 0 0 GeneID:3751,Genbank:XM_011516165.3,HGNC:HGNC:6238,MIM:605410 potassium voltage-gated channel subfamily D member 2 GO:0001508,GO:0005249,GO:0005250,GO:0005886,GO:0005887,GO:0007268,GO:0008076,GO:0019228,GO:0019233,GO:0030054,GO:0031226,GO:0032809,GO:0034765,GO:0043197,GO:0043204,GO:0044853,GO:0045211,GO:0045475,GO:0046872,GO:0051260,GO:0061337,GO:0071456,GO:0071805 action potential|voltage-gated potassium channel activity|A-type (transient outward) potassium channel activity|plasma membrane|integral component of plasma membrane|chemical synaptic transmission|voltage-gated potassium channel complex|neuronal action potential|sensory perception of pain|cell junction|intrinsic component of plasma membrane|neuronal cell body membrane|regulation of ion transmembrane transport|dendritic spine|perikaryon|plasma membrane raft|postsynaptic membrane|locomotor rhythm|metal ion binding|protein homooligomerization|cardiac conduction|cellular response to hypoxia|potassium ion transmembrane transport hsa04726 Serotonergic synapse KCND3 90.3938193346858 95.4756454857142 85.3119931836575 0.893547173728431 -0.162384198292633 0.614402587826454 1 0.175092 0.188594 0.209317 0.123197 GeneID:3752,Genbank:XM_006710630.3,HGNC:HGNC:6239,MIM:605411 potassium voltage-gated channel subfamily D member 3 KCNE1 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0 0 GeneID:3753,Genbank:NM_000219.5,HGNC:HGNC:6240,MIM:176261 potassium voltage-gated channel subfamily E regulatory subunit 1 GO:0005249,GO:0016021 voltage-gated potassium channel activity|integral component of membrane hsa04261 Adrenergic signaling in cardiomyocytes KCNE2 2.69471697080861 1.02816907859967 4.36126486301754 4.24177788828025 2.08466907917445 0.348116099401105 1 0.0466698 0.0430514 0.0881589 0.206525 GeneID:9992,Genbank:NM_172201.1,HGNC:HGNC:6242,MIM:603796 potassium voltage-gated channel subfamily E regulatory subunit 2 GO:0005242,GO:0005251,GO:0005764,GO:0005783,GO:0005794,GO:0005886,GO:0007568,GO:0008076,GO:0009986,GO:0010107,GO:0015459,GO:0035690,GO:0042803,GO:0043586,GO:0044325,GO:0060306,GO:0060307,GO:0061337,GO:0071435,GO:0071805,GO:0086002,GO:0086005,GO:0086009,GO:0086011,GO:0086091,GO:0098915,GO:1901379,GO:1901387,GO:1901800,GO:1901979,GO:1902159,GO:1902259,GO:1902260,GO:1902282 inward rectifier potassium channel activity|delayed rectifier potassium channel activity|lysosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|aging|voltage-gated potassium channel complex|cell surface|potassium ion import|potassium channel regulator activity|cellular response to drug|protein homodimerization activity|tongue development|ion channel binding|regulation of membrane repolarization|regulation of ventricular cardiac muscle cell membrane repolarization|cardiac conduction|potassium ion export|potassium ion transmembrane transport|cardiac muscle cell action potential involved in contraction|ventricular cardiac muscle cell action potential|membrane repolarization|membrane repolarization during action potential|regulation of heart rate by cardiac conduction|membrane repolarization during ventricular cardiac muscle cell action potential|regulation of potassium ion transmembrane transport|positive regulation of voltage-gated calcium channel activity|positive regulation of proteasomal protein catabolic process|regulation of inward rectifier potassium channel activity|regulation of cyclic nucleotide-gated ion channel activity|regulation of delayed rectifier potassium channel activity|negative regulation of delayed rectifier potassium channel activity|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization hsa04971 Gastric acid secretion KCNE3 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0.01169 0 0.0111286 0.0103703 GeneID:10008,Genbank:NM_005472.4,HGNC:HGNC:6243,MIM:604433 potassium voltage-gated channel subfamily E regulatory subunit 3 GO:0005249,GO:0005737,GO:0008076,GO:0015459,GO:0030425,GO:0031982,GO:0032809,GO:0043204,GO:0044325,GO:0045121,GO:0086091,GO:1901387,GO:1902260,GO:1903765,GO:1903817,GO:1905025 voltage-gated potassium channel activity|cytoplasm|voltage-gated potassium channel complex|potassium channel regulator activity|dendrite|vesicle|neuronal cell body membrane|perikaryon|ion channel binding|membrane raft|regulation of heart rate by cardiac conduction|positive regulation of voltage-gated calcium channel activity|negative regulation of delayed rectifier potassium channel activity|negative regulation of potassium ion export across plasma membrane|negative regulation of voltage-gated potassium channel activity|negative regulation of membrane repolarization during ventricular cardiac muscle cell action potential hsa04974 Protein digestion and absorption KCNE4 517.268336293652 411.268648440721 623.268024146582 1.51547662704082 0.599771601833673 0.000616562102220563 0.0715569465881488 5.48124 6.36788 9.97172 8.44521 GeneID:23704,Genbank:NM_080671.3,HGNC:HGNC:6244,MIM:607775 potassium voltage-gated channel subfamily E regulatory subunit 4 GO:0005249,GO:0016021,GO:0016324,GO:0034765,GO:0044325 voltage-gated potassium channel activity|integral component of membrane|apical plasma membrane|regulation of ion transmembrane transport|ion channel binding KCNE5 7.23225418423562 7.19718355019767 7.26732481827358 1.00974565503112 0.0139919380899862 1 1 0.276854 0.206223 0.109878 0.309345 GeneID:23630,Genbank:NM_012282.3,HGNC:HGNC:6241,MIM:300328 potassium voltage-gated channel subfamily E regulatory subunit 5 GO:0005249,GO:0005886,GO:0008016,GO:0008076,GO:0015459,GO:0044325,GO:0060048,GO:0060306,GO:0060307,GO:0060372,GO:0071435,GO:0071805,GO:0086005,GO:0086013,GO:0086014,GO:0086091,GO:1901379,GO:1901380,GO:1901381,GO:2001257 voltage-gated potassium channel activity|plasma membrane|regulation of heart contraction|voltage-gated potassium channel complex|potassium channel regulator activity|ion channel binding|cardiac muscle contraction|regulation of membrane repolarization|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane repolarization|potassium ion export|potassium ion transmembrane transport|ventricular cardiac muscle cell action potential|membrane repolarization during cardiac muscle cell action potential|atrial cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|regulation of potassium ion transmembrane transport|negative regulation of potassium ion transmembrane transport|positive regulation of potassium ion transmembrane transport|regulation of cation channel activity KCNF1 3.83612282702223 6.21704074628294 1.45520490776151 0.234067133729428 -2.09500572060123 0.225666031321666 1 0.185027 0.111203 0.0723268 0 GeneID:3754,Genbank:NM_002236.4,HGNC:HGNC:6246,MIM:603787 potassium voltage-gated channel modifier subfamily F member 1 GO:0005249,GO:0005267,GO:0005886,GO:0006813,GO:0008076,GO:0016021,GO:0034765,GO:0051260 voltage-gated potassium channel activity|potassium channel activity|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|integral component of membrane|regulation of ion transmembrane transport|protein homooligomerization KCNG1 23.2767096269993 22.3217534259751 24.2316658280236 1.08556283037452 0.118443228897781 0.852879491208742 1 0.237938 0.117587 0.230645 0.197907 GeneID:3755,Genbank:XM_011528804.1,HGNC:HGNC:6248,MIM:603788 potassium voltage-gated channel modifier subfamily G member 1 GO:0005251,GO:0005267,GO:0005886,GO:0006813,GO:0008076,GO:0051260,GO:0071805,GO:1902259 delayed rectifier potassium channel activity|potassium channel activity|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|protein homooligomerization|potassium ion transmembrane transport|regulation of delayed rectifier potassium channel activity KCNG2 7.51617993321226 5.82302189369546 9.20933797272905 1.58153930053052 0.661329406614724 0.544390725996218 1 0.0606821 0.0118933 0.0627782 0.0411464 GeneID:26251,Genbank:XM_011525920.3,HGNC:HGNC:6249,MIM:605696 potassium voltage-gated channel modifier subfamily G member 2 GO:0005251,GO:0005886,GO:0006813,GO:0008016,GO:0008076,GO:0016021,GO:0034765,GO:0050796,GO:0051260,GO:0070062 delayed rectifier potassium channel activity|plasma membrane|potassium ion transport|regulation of heart contraction|voltage-gated potassium channel complex|integral component of membrane|regulation of ion transmembrane transport|regulation of insulin secretion|protein homooligomerization|extracellular exosome KCNG3 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0.0159076 0 0.015229 0 GeneID:170850,Genbank:NM_172344.2,HGNC:HGNC:18306,MIM:606767 potassium voltage-gated channel modifier subfamily G member 3 GO:0005251,GO:0005783,GO:0005886,GO:0008076,GO:0034765,GO:0051260,GO:0071805 delayed rectifier potassium channel activity|endoplasmic reticulum|plasma membrane|voltage-gated potassium channel complex|regulation of ion transmembrane transport|protein homooligomerization|potassium ion transmembrane transport KCNH1 84.7598351366896 80.8313383567862 88.688331916593 1.09720231929263 0.133829576905496 0.676909810545438 1 0.378553 0.320598 0.4099 0.373511 GeneID:3756,Genbank:XM_017001246.1,HGNC:HGNC:6250,MIM:603305 potassium voltage-gated channel subfamily H member 1 KCNH2 68.9428892243011 80.7068768429472 57.1789016056551 0.708476202305823 -0.497208701012926 0.239671002950289 1 0.448986 0.662219 0.370939 0.425798 GeneID:3757,Genbank:NM_000238.3,HGNC:HGNC:6251,MIM:152427 potassium voltage-gated channel subfamily H member 2 KCNH3 12.0156970706947 13.856269423753 10.1751247176364 0.734333636743073 -0.445492409593885 0.623006650993473 1 0.151274 0.127192 0.0753445 0.0706401 GeneID:23416,Genbank:XM_011538085.2,HGNC:HGNC:6252,MIM:604527 potassium voltage-gated channel subfamily H member 3 GO:0000155,GO:0005249,GO:0005622,GO:0005886,GO:0005887,GO:0006813,GO:0016021,GO:0034765,GO:0042391 phosphorelay sensor kinase activity|voltage-gated potassium channel activity|intracellular|plasma membrane|integral component of plasma membrane|potassium ion transport|integral component of membrane|regulation of ion transmembrane transport|regulation of membrane potential KCNH4 1.27070322989325 2.05633815719933 0.48506830258717 0.235889365223771 -2.08381771694066 0.63179572723844 1 0.0120342 0.0207422 0.0111254 0 GeneID:23415,Genbank:NM_012285.2,HGNC:HGNC:6253,MIM:604528 potassium voltage-gated channel subfamily H member 4 GO:0000155,GO:0005249,GO:0005622,GO:0005886,GO:0006813,GO:0008076,GO:0034765,GO:0042391 phosphorelay sensor kinase activity|voltage-gated potassium channel activity|intracellular|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|regulation of ion transmembrane transport|regulation of membrane potential KCNH5 10.9458956404818 8.81147658012458 13.080314700839 1.48446342470493 0.569941547587376 0.529326695504331 1 0.0805304 0.0472709 0.0770637 0.134239 GeneID:27133,Genbank:NM_172375.2,HGNC:HGNC:6254,MIM:605716 potassium voltage-gated channel subfamily H member 5 GO:0000155,GO:0005249,GO:0005516,GO:0005622,GO:0005886,GO:0005887,GO:0009986,GO:0010389,GO:0034765,GO:0042391,GO:0044325,GO:0046982 phosphorelay sensor kinase activity|voltage-gated potassium channel activity|calmodulin binding|intracellular|plasma membrane|integral component of plasma membrane|cell surface|regulation of G2/M transition of mitotic cell cycle|regulation of ion transmembrane transport|regulation of membrane potential|ion channel binding|protein heterodimerization activity KCNH8 16.0743416515298 16.1527389543771 15.9959443486824 0.990293001939951 -0.0140726505993973 1 1 0.0735034 0.0700068 0.128184 0.0656891 GeneID:131096,Genbank:NM_144633.2,HGNC:HGNC:18864,MIM:608260 potassium voltage-gated channel subfamily H member 8 GO:0000155,GO:0005249,GO:0005622,GO:0005886,GO:0005887,GO:0034765,GO:0042391 phosphorelay sensor kinase activity|voltage-gated potassium channel activity|intracellular|plasma membrane|integral component of plasma membrane|regulation of ion transmembrane transport|regulation of membrane potential KCNIP1 126.352604025589 115.558764310858 137.14644374032 1.18681126921183 0.247090530918708 0.375367345577293 1 0.749534 0.75814 0.867772 0.928298 GeneID:30820,Genbank:XM_017009408.1,HGNC:HGNC:15521,MIM:604660 potassium voltage-gated channel interacting protein 1 GO:0005244,GO:0005267,GO:0005509,GO:0005737,GO:0005886,GO:0008076,GO:0015459,GO:0030425,GO:0031234,GO:0061337,GO:1901379 voltage-gated ion channel activity|potassium channel activity|calcium ion binding|cytoplasm|plasma membrane|voltage-gated potassium channel complex|potassium channel regulator activity|dendrite|extrinsic component of cytoplasmic side of plasma membrane|cardiac conduction|regulation of potassium ion transmembrane transport KCNIP2 13.688661386829 13.3181717471107 14.0591510265474 1.05563671151766 0.0781134287623365 0.9752108596099 1 0.136985 0.134861 0.156561 0.0532182 GeneID:30819,Genbank:XM_005269730.2,HGNC:HGNC:15522,MIM:604661 potassium voltage-gated channel interacting protein 2 GO:0005250,GO:0005509,GO:0005513,GO:0005737,GO:0005886,GO:0006813,GO:0006936,GO:0007165,GO:0007268,GO:0008016,GO:0008076,GO:0015459,GO:0034705,GO:0042802,GO:0044325,GO:0045163,GO:0046923,GO:0047485,GO:0061337,GO:0071435,GO:0071805,GO:0086009,GO:0086013,GO:0097623,GO:1901379,GO:2001257 A-type (transient outward) potassium channel activity|calcium ion binding|detection of calcium ion|cytoplasm|plasma membrane|potassium ion transport|muscle contraction|signal transduction|chemical synaptic transmission|regulation of heart contraction|voltage-gated potassium channel complex|potassium channel regulator activity|potassium channel complex|identical protein binding|ion channel binding|clustering of voltage-gated potassium channels|ER retention sequence binding|protein N-terminus binding|cardiac conduction|potassium ion export|potassium ion transmembrane transport|membrane repolarization|membrane repolarization during cardiac muscle cell action potential|potassium ion export across plasma membrane|regulation of potassium ion transmembrane transport|regulation of cation channel activity KCNIP3 423.665417326464 410.192453087437 437.138381565492 1.06569094159397 0.0917891063172376 0.641942181874509 1 4.54105 5.23387 5.54882 5.322 GeneID:30818,Genbank:NM_013434.4,HGNC:HGNC:15523,MIM:604662 potassium voltage-gated channel interacting protein 3 GO:0000978,GO:0001078,GO:0003677,GO:0003714,GO:0005244,GO:0005267,GO:0005509,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0006351,GO:0006357,GO:0006886,GO:0006915,GO:0007165,GO:0008076,GO:0015459,GO:0030424,GO:0030425,GO:0032993,GO:0043679,GO:0044325,GO:0061337,GO:0072659,GO:1901379 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|transcription corepressor activity|voltage-gated ion channel activity|potassium channel activity|calcium ion binding|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|intracellular protein transport|apoptotic process|signal transduction|voltage-gated potassium channel complex|potassium channel regulator activity|axon|dendrite|protein-DNA complex|axon terminus|ion channel binding|cardiac conduction|protein localization to plasma membrane|regulation of potassium ion transmembrane transport KCNIP4 14.3912723648388 13.7602168743831 15.0223278552945 1.09172173610585 0.126605181259903 0.925078247315116 1 0.0426004 0.0561707 0.0373812 0.0347814 GeneID:80333,Genbank:XM_011513885.3,HGNC:HGNC:30083,MIM:608182 potassium voltage-gated channel interacting protein 4 GO:0005244,GO:0005267,GO:0005509,GO:0005737,GO:0005829,GO:0005886,GO:0008076,GO:0015459,GO:0072659,GO:1901379 voltage-gated ion channel activity|potassium channel activity|calcium ion binding|cytoplasm|cytosol|plasma membrane|voltage-gated potassium channel complex|potassium channel regulator activity|protein localization to plasma membrane|regulation of potassium ion transmembrane transport KCNJ10 62.3272414278465 40.3387254388117 84.3157574168813 2.09019388936263 1.0636367749606 0.0036059046526786 0.231008675669202 0.325085 0.234394 0.521295 0.651195 GeneID:3766,Genbank:NM_002241.4,HGNC:HGNC:6256,MIM:602208 potassium voltage-gated channel subfamily J member 10 GO:0005242,GO:0005524,GO:0005886,GO:0005887,GO:0006813,GO:0007601,GO:0007628,GO:0010107,GO:0015272,GO:0015467,GO:0016323,GO:0022010,GO:0034765,GO:0048169,GO:0051935,GO:0055075,GO:0060075,GO:0098793 inward rectifier potassium channel activity|ATP binding|plasma membrane|integral component of plasma membrane|potassium ion transport|visual perception|adult walking behavior|potassium ion import|ATP-activated inward rectifier potassium channel activity|G-protein activated inward rectifier potassium channel activity|basolateral plasma membrane|central nervous system myelination|regulation of ion transmembrane transport|regulation of long-term neuronal synaptic plasticity|glutamate reuptake|potassium ion homeostasis|regulation of resting membrane potential|presynapse hsa04971 Gastric acid secretion KCNJ11 11.6961204080035 12.7320477957835 10.6601930202236 0.837272463252452 -0.25623091725107 0.794861754631159 1 0.130134 0.156668 0.108718 0.146638 GeneID:3767,Genbank:XM_017017680.1,HGNC:HGNC:6257,MIM:600937 potassium voltage-gated channel subfamily J member 11 GO:0001669,GO:0002931,GO:0005249,GO:0005524,GO:0005635,GO:0005739,GO:0005768,GO:0005783,GO:0005829,GO:0005886,GO:0005887,GO:0006006,GO:0008022,GO:0008282,GO:0010107,GO:0014704,GO:0015272,GO:0030315,GO:0030506,GO:0030673,GO:0030955,GO:0031072,GO:0032355,GO:0033198,GO:0033574,GO:0042391,GO:0042493,GO:0043025,GO:0043209,GO:0044325,GO:0046676,GO:0050796,GO:0050877,GO:0055085,GO:0070852,GO:0071316,GO:0071333,GO:0071356,GO:0071805,GO:1903078,GO:1903779,GO:2001259 acrosomal vesicle|response to ischemia|voltage-gated potassium channel activity|ATP binding|nuclear envelope|mitochondrion|endosome|endoplasmic reticulum|cytosol|plasma membrane|integral component of plasma membrane|glucose metabolic process|protein C-terminus binding|inward rectifying potassium channel|potassium ion import|intercalated disc|ATP-activated inward rectifier potassium channel activity|T-tubule|ankyrin binding|axolemma|potassium ion binding|heat shock protein binding|response to estradiol|response to ATP|response to testosterone|regulation of membrane potential|response to drug|neuronal cell body|myelin sheath|ion channel binding|negative regulation of insulin secretion|regulation of insulin secretion|nervous system process|transmembrane transport|cell body fiber|cellular response to nicotine|cellular response to glucose stimulus|cellular response to tumor necrosis factor|potassium ion transmembrane transport|positive regulation of protein localization to plasma membrane|regulation of cardiac conduction|positive regulation of cation channel activity hsa04911,hsa04930 Insulin secretion|Type II diabetes mellitus KCNJ13 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:3769,Genbank:NM_001172417.1,HGNC:HGNC:6259,MIM:603208 potassium voltage-gated channel subfamily J member 13 GO:0005242,GO:0005887,GO:0006813,GO:0010107,GO:0034765 inward rectifier potassium channel activity|integral component of plasma membrane|potassium ion transport|potassium ion import|regulation of ion transmembrane transport hsa04974 Protein digestion and absorption KCNJ14 52.0058254036436 56.9913444502541 47.0203063570332 0.825042939600692 -0.27745888809027 0.498361423978546 1 0.645985 0.550318 0.625149 0.328233 GeneID:3770,Genbank:NM_013348.3,HGNC:HGNC:6260,MIM:603953 potassium voltage-gated channel subfamily J member 14 GO:0005242,GO:0005886,GO:0008076,GO:0010107,GO:0030425,GO:0034765,GO:0043025,GO:0061337 inward rectifier potassium channel activity|plasma membrane|voltage-gated potassium channel complex|potassium ion import|dendrite|regulation of ion transmembrane transport|neuronal cell body|cardiac conduction hsa04725,hsa04921 Cholinergic synapse|Oxytocin signaling pathway KCNJ16 2.43610931725454 2.45035700978681 2.42186162472226 0.988370925154687 -0.0168755232656929 1 1 0 0.0424873 0.00854432 0.0318736 GeneID:3773,Genbank:NM_001291622.1,HGNC:HGNC:6262,MIM:605722 potassium voltage-gated channel subfamily J member 16 GO:0005242,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0010107,GO:0015467,GO:0016323,GO:0034765 inward rectifier potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium ion import|G-protein activated inward rectifier potassium channel activity|basolateral plasma membrane|regulation of ion transmembrane transport hsa04971 Gastric acid secretion KCNJ2 116.685137205028 90.8532804591422 142.516993950914 1.56864995111548 0.64952344654869 0.245697868129243 1 0.906772 0.564111 1.54112 0.820321 GeneID:3759,Genbank:NM_000891.2,HGNC:HGNC:6263,MIM:600681 potassium voltage-gated channel subfamily J member 2 GO:0005242,GO:0005546,GO:0005790,GO:0005791,GO:0005794,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0010107,GO:0014704,GO:0014861,GO:0015467,GO:0015693,GO:0030007,GO:0030315,GO:0031224,GO:0042802,GO:0043025,GO:0043197,GO:0051289,GO:0055119,GO:0060075,GO:0060306,GO:0061337,GO:0071260,GO:0071805,GO:0086002,GO:0086004,GO:0086008,GO:0086011,GO:0086012,GO:0086013,GO:0086091,GO:0090076,GO:1901381 inward rectifier potassium channel activity|phosphatidylinositol-4,5-bisphosphate binding|smooth endoplasmic reticulum|rough endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium ion import|intercalated disc|regulation of skeletal muscle contraction via regulation of action potential|G-protein activated inward rectifier potassium channel activity|magnesium ion transport|cellular potassium ion homeostasis|T-tubule|intrinsic component of membrane|identical protein binding|neuronal cell body|dendritic spine|protein homotetramerization|relaxation of cardiac muscle|regulation of resting membrane potential|regulation of membrane repolarization|cardiac conduction|cellular response to mechanical stimulus|potassium ion transmembrane transport|cardiac muscle cell action potential involved in contraction|regulation of cardiac muscle cell contraction|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|membrane repolarization during action potential|membrane depolarization during cardiac muscle cell action potential|membrane repolarization during cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|relaxation of skeletal muscle|positive regulation of potassium ion transmembrane transport hsa04725,hsa04921,hsa04924,hsa04971 Cholinergic synapse|Oxytocin signaling pathway|Renin secretion|Gastric acid secretion KCNJ3 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.00840427 0.00845783 0 GeneID:3760,Genbank:NM_002239.3,HGNC:HGNC:6264,MIM:601534 potassium voltage-gated channel subfamily J member 3 GO:0005886,GO:0006813,GO:0008076,GO:0009897,GO:0010107,GO:0015467,GO:0030315,GO:0034765,GO:0051602,GO:0086089,GO:0086091,GO:0098914,GO:0099625,GO:1902282,GO:1990573 plasma membrane|potassium ion transport|voltage-gated potassium channel complex|external side of plasma membrane|potassium ion import|G-protein activated inward rectifier potassium channel activity|T-tubule|regulation of ion transmembrane transport|response to electrical stimulus|voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|regulation of heart rate by cardiac conduction|membrane repolarization during atrial cardiac muscle cell action potential|ventricular cardiac muscle cell membrane repolarization|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|potassium ion import across plasma membrane hsa04713,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04915,hsa04921,hsa05032 Circadian entrainment|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Estrogen signaling pathway|Oxytocin signaling pathway|Morphine addiction KCNJ4 16.3217705357184 17.6229531602492 15.0205879111877 0.852330921758823 -0.230514422079227 0.799027842499288 1 0.475402 0.281394 0.218595 0.387869 GeneID:3761,Genbank:NM_152868.2,HGNC:HGNC:6265,MIM:600504 potassium voltage-gated channel subfamily J member 4 GO:0005242,GO:0005886,GO:0006813,GO:0008076,GO:0010107,GO:0015467,GO:0016323,GO:0030054,GO:0030165,GO:0030659,GO:0034765,GO:0045211,GO:0061337 inward rectifier potassium channel activity|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium ion import|G-protein activated inward rectifier potassium channel activity|basolateral plasma membrane|cell junction|PDZ domain binding|cytoplasmic vesicle membrane|regulation of ion transmembrane transport|postsynaptic membrane|cardiac conduction hsa04725,hsa04921 Cholinergic synapse|Oxytocin signaling pathway KCNJ5 1.24418854286568 1.51824048055703 0.97013660517434 0.638987444741564 -0.646140510486663 0.974454614671682 1 0.00649239 0.0115981 0.012139 0 GeneID:3762,Genbank:NM_001354169.1,HGNC:HGNC:6266,MIM:600734 potassium voltage-gated channel subfamily J member 5 GO:0005886,GO:0006813,GO:0008076,GO:0009897,GO:0010107,GO:0015467,GO:0030315,GO:0034765,GO:0086089,GO:0086091,GO:0098914,GO:0099625,GO:1902282,GO:1990573 plasma membrane|potassium ion transport|voltage-gated potassium channel complex|external side of plasma membrane|potassium ion import|G-protein activated inward rectifier potassium channel activity|T-tubule|regulation of ion transmembrane transport|voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|regulation of heart rate by cardiac conduction|membrane repolarization during atrial cardiac muscle cell action potential|ventricular cardiac muscle cell membrane repolarization|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|potassium ion import across plasma membrane hsa04713,hsa04723,hsa04726,hsa04728,hsa04915,hsa04921,hsa04925,hsa05032 Circadian entrainment|Retrograde endocannabinoid signaling|Serotonergic synapse|Dopaminergic synapse|Estrogen signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Morphine addiction KCNJ6 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0.0250768 0 0 GeneID:3763,Genbank:NM_002240.4,HGNC:HGNC:6267,MIM:600877 potassium voltage-gated channel subfamily J member 6 GO:0005242,GO:0005794,GO:0005886,GO:0006813,GO:0008076,GO:0010107,GO:0015467,GO:0034765 inward rectifier potassium channel activity|Golgi apparatus|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium ion import|G-protein activated inward rectifier potassium channel activity|regulation of ion transmembrane transport hsa04713,hsa04723,hsa04725,hsa04726,hsa04727,hsa04728,hsa04915,hsa04921,hsa05032 Circadian entrainment|Retrograde endocannabinoid signaling|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Estrogen signaling pathway|Oxytocin signaling pathway|Morphine addiction KCNJ8 103.891900354058 111.35003544709 96.4337652610265 0.866041621574959 -0.207491732987508 0.473152976787964 1 1.61723 1.86462 1.44197 1.61392 GeneID:3764,Genbank:NM_004982.3,HGNC:HGNC:6269,MIM:600935 potassium voltage-gated channel subfamily J member 8 GO:0001822,GO:0005242,GO:0005524,GO:0005739,GO:0005886,GO:0006813,GO:0007507,GO:0008076,GO:0008282,GO:0009268,GO:0010107,GO:0015272,GO:0017098,GO:0030016,GO:0032496,GO:0034765,GO:0042311,GO:0042383,GO:0043330,GO:0051607,GO:0098915,GO:1902282,GO:1990573 kidney development|inward rectifier potassium channel activity|ATP binding|mitochondrion|plasma membrane|potassium ion transport|heart development|voltage-gated potassium channel complex|inward rectifying potassium channel|response to pH|potassium ion import|ATP-activated inward rectifier potassium channel activity|sulfonylurea receptor binding|myofibril|response to lipopolysaccharide|regulation of ion transmembrane transport|vasodilation|sarcolemma|response to exogenous dsRNA|defense response to virus|membrane repolarization during ventricular cardiac muscle cell action potential|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|potassium ion import across plasma membrane hsa04022 cGMP-PKG signaling pathway KCNJ9 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00324748 0 0 GeneID:3765,Genbank:XM_017001247.1,HGNC:HGNC:6270,MIM:600932 potassium voltage-gated channel subfamily J member 9 GO:0005242,GO:0005886,GO:0005887,GO:0010107,GO:0015467,GO:0034765 inward rectifier potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion import|G-protein activated inward rectifier potassium channel activity|regulation of ion transmembrane transport hsa04713,hsa04723,hsa04726,hsa04728,hsa04915,hsa04921,hsa05032 Circadian entrainment|Retrograde endocannabinoid signaling|Serotonergic synapse|Dopaminergic synapse|Estrogen signaling pathway|Oxytocin signaling pathway|Morphine addiction KCNK1 195.320196824794 209.862161893918 180.77823175567 0.861414130704756 -0.21522110503122 0.345066700596679 1 3.03816 3.5655 3.15034 2.49167 GeneID:3775,Genbank:NM_002245.3,HGNC:HGNC:6272,MIM:601745 potassium two pore domain channel subfamily K member 1 GO:0005242,GO:0005267,GO:0005272,GO:0005886,GO:0005887,GO:0006813,GO:0008076,GO:0016021,GO:0016324,GO:0022841,GO:0030054,GO:0030322,GO:0030425,GO:0031526,GO:0034705,GO:0035094,GO:0035725,GO:0042802,GO:0043204,GO:0043231,GO:0045202,GO:0055037,GO:0060075,GO:0061337,GO:0071805,GO:1902937 inward rectifier potassium channel activity|potassium channel activity|sodium channel activity|plasma membrane|integral component of plasma membrane|potassium ion transport|voltage-gated potassium channel complex|integral component of membrane|apical plasma membrane|potassium ion leak channel activity|cell junction|stabilization of membrane potential|dendrite|brush border membrane|potassium channel complex|response to nicotine|sodium ion transmembrane transport|identical protein binding|perikaryon|intracellular membrane-bounded organelle|synapse|recycling endosome|regulation of resting membrane potential|cardiac conduction|potassium ion transmembrane transport|inward rectifier potassium channel complex KCNK10 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.00801158 0 0 GeneID:54207,Genbank:NM_021161.4,HGNC:HGNC:6273,MIM:605873 potassium two pore domain channel subfamily K member 10 GO:0005244,GO:0005267,GO:0005886,GO:0005887,GO:0006810,GO:0007165,GO:0007613,GO:0022841,GO:0030322,GO:0034765,GO:0071805 voltage-gated ion channel activity|potassium channel activity|plasma membrane|integral component of plasma membrane|transport|signal transduction|memory|potassium ion leak channel activity|stabilization of membrane potential|regulation of ion transmembrane transport|potassium ion transmembrane transport hsa04971 Gastric acid secretion KCNK12 2.49087863541646 3.52655236307142 1.45520490776151 0.412642365104176 -1.27703614766183 0.588136326749034 1 0.180688 0.364749 0.163913 0 GeneID:56660,Genbank:NM_022055.1,HGNC:HGNC:6274,MIM:607366 potassium two pore domain channel subfamily K member 12 GO:0005244,GO:0005887,GO:0022841,GO:0030322,GO:0034765,GO:0071805 voltage-gated ion channel activity|integral component of plasma membrane|potassium ion leak channel activity|stabilization of membrane potential|regulation of ion transmembrane transport|potassium ion transmembrane transport KCNK13 38.2001078252406 35.2076887009213 41.19252694956 1.16998668385983 0.226492109946528 0.654398632139337 1 0.684374 0.767676 0.814673 0.884731 GeneID:56659,Genbank:NM_022054.3,HGNC:HGNC:6275,MIM:607367 potassium two pore domain channel subfamily K member 13 GO:0005244,GO:0005267,GO:0005886,GO:0005887,GO:0022841,GO:0030322,GO:0034765,GO:0071805 voltage-gated ion channel activity|potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion leak channel activity|stabilization of membrane potential|regulation of ion transmembrane transport|potassium ion transmembrane transport KCNK15 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0.0113924 0 0.0106208 0.00993048 GeneID:60598,Genbank:XM_017028003.1,HGNC:HGNC:13814,MIM:607368 potassium two pore domain channel subfamily K member 15 GO:0005267,GO:0005886,GO:0005887,GO:0022841,GO:0030322,GO:0034765,GO:0061337,GO:0071805 potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion leak channel activity|stabilization of membrane potential|regulation of ion transmembrane transport|cardiac conduction|potassium ion transmembrane transport KCNK2 67.1365649515477 43.6349550835664 90.638174819529 2.07719188998695 1.05463449781235 0.0051353609200905 0.284594949813735 0.206703 0.328802 0.65323 0.485666 GeneID:3776,Genbank:XM_017001248.1,HGNC:HGNC:6277,MIM:603219 potassium two pore domain channel subfamily K member 2 GO:0003231,GO:0005634,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0007186,GO:0007613,GO:0008076,GO:0009612,GO:0009986,GO:0010942,GO:0015271,GO:0016324,GO:0019870,GO:0022841,GO:0030322,GO:0030424,GO:0043025,GO:0044305,GO:0048678,GO:0060044,GO:0071456,GO:0071805,GO:0090102,GO:0097449,GO:1900039,GO:2000279 cardiac ventricle development|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|memory|voltage-gated potassium channel complex|response to mechanical stimulus|cell surface|positive regulation of cell death|outward rectifier potassium channel activity|apical plasma membrane|potassium channel inhibitor activity|potassium ion leak channel activity|stabilization of membrane potential|axon|neuronal cell body|calyx of Held|response to axon injury|negative regulation of cardiac muscle cell proliferation|cellular response to hypoxia|potassium ion transmembrane transport|cochlea development|astrocyte projection|positive regulation of cellular response to hypoxia|negative regulation of DNA biosynthetic process hsa04927,hsa04934,hsa04971 Cortisol synthesis and secretion|Cushing syndrome|Gastric acid secretion KCNK3 10.7551084060169 13.2701454724258 8.24007133960811 0.620948079034271 -0.687455453255374 0.450138557119679 1 0.0851981 0.0959035 0.0648973 0.0471912 GeneID:3777,Genbank:NM_002246.2,HGNC:HGNC:6278,MIM:603220 potassium two pore domain channel subfamily K member 3 GO:0005216,GO:0005252,GO:0005267,GO:0005615,GO:0005886,GO:0005887,GO:0006813,GO:0007268,GO:0007420,GO:0008022,GO:0008083,GO:0022841,GO:0030322,GO:0034220,GO:0042493,GO:0042803,GO:0044548,GO:0046982,GO:0051481,GO:0061337,GO:0071294,GO:0071456,GO:0090102 ion channel activity|open rectifier potassium channel activity|potassium channel activity|extracellular space|plasma membrane|integral component of plasma membrane|potassium ion transport|chemical synaptic transmission|brain development|protein C-terminus binding|growth factor activity|potassium ion leak channel activity|stabilization of membrane potential|ion transmembrane transport|response to drug|protein homodimerization activity|S100 protein binding|protein heterodimerization activity|negative regulation of cytosolic calcium ion concentration|cardiac conduction|cellular response to zinc ion|cellular response to hypoxia|cochlea development hsa04925,hsa04927,hsa04934 Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome KCNK6 2.48587553604627 2.54640955915669 2.42534151293585 0.952455391244707 -0.070276570089394 1 1 0.0280002 0.0376438 0.065878 0 GeneID:9424,Genbank:NM_004823.1,HGNC:HGNC:6281,MIM:603939 potassium two pore domain channel subfamily K member 6 GO:0003085,GO:0005242,GO:0005267,GO:0005886,GO:0006813,GO:0008076,GO:0022841,GO:0030322,GO:0034765,GO:0060075,GO:0061337 negative regulation of systemic arterial blood pressure|inward rectifier potassium channel activity|potassium channel activity|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium ion leak channel activity|stabilization of membrane potential|regulation of ion transmembrane transport|regulation of resting membrane potential|cardiac conduction KCNK7 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0.0456533 0 0 0.0787051 GeneID:10089,Genbank:NM_033347.1,HGNC:HGNC:6282,MIM:603940 potassium two pore domain channel subfamily K member 7 GO:0005244,GO:0005267,GO:0005886,GO:0005887,GO:0006813,GO:0022841,GO:0030322,GO:0034765,GO:0071805 voltage-gated ion channel activity|potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion transport|potassium ion leak channel activity|stabilization of membrane potential|regulation of ion transmembrane transport|potassium ion transmembrane transport KCNK9 1.26526514449636 1.07619535328461 1.45433493570811 1.35136704620532 0.434419579785585 1 1 0.0088934 0 0.0167468 0.00781733 GeneID:51305,Genbank:XM_011517102.2,HGNC:HGNC:6283,MIM:605874 potassium two pore domain channel subfamily K member 9 GO:0005249,GO:0005267,GO:0005886,GO:0005887,GO:0006813,GO:0008021,GO:0022841,GO:0030322,GO:0042803,GO:0046982,GO:0071805 voltage-gated potassium channel activity|potassium channel activity|plasma membrane|integral component of plasma membrane|potassium ion transport|synaptic vesicle|potassium ion leak channel activity|stabilization of membrane potential|protein homodimerization activity|protein heterodimerization activity|potassium ion transmembrane transport hsa04925 Aldosterone synthesis and secretion KCNMA1 1383.27111043951 1393.53471139067 1373.00750948835 0.985269687411066 -0.0214094226668154 0.896495977407103 1 1.12182 1.07508 1.18147 0.9889 GeneID:3778,Genbank:NM_001271518.1,HGNC:HGNC:6284,MIM:600150 potassium calcium-activated channel subfamily M alpha 1 GO:0005249,GO:0008076,GO:0016324,GO:0034765,GO:0046872,GO:0060072 voltage-gated potassium channel activity|voltage-gated potassium channel complex|apical plasma membrane|regulation of ion transmembrane transport|metal ion binding|large conductance calcium-activated potassium channel activity hsa04022,hsa04270,hsa04911,hsa04924,hsa04970,hsa04972 cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion|Renin secretion|Salivary secretion|Pancreatic secretion KCNMB1 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.0298121 0 0.0555756 0 GeneID:3779,Genbank:NM_004137.3,HGNC:HGNC:6285,MIM:603951 potassium calcium-activated channel subfamily M regulatory beta subunit 1 GO:0005513,GO:0005886,GO:0006813,GO:0007268,GO:0007568,GO:0008076,GO:0015269,GO:0015459,GO:0071361,GO:0071456,GO:0071805,GO:0097755,GO:1901381,GO:1903413 detection of calcium ion|plasma membrane|potassium ion transport|chemical synaptic transmission|aging|voltage-gated potassium channel complex|calcium-activated potassium channel activity|potassium channel regulator activity|cellular response to ethanol|cellular response to hypoxia|potassium ion transmembrane transport|positive regulation of blood vessel diameter|positive regulation of potassium ion transmembrane transport|cellular response to bile acid hsa04022,hsa04270,hsa04911 cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion KCNMB2 5.88331185133976 3.52655236307142 8.24007133960811 2.33657989199159 1.22439836645997 0.356305915603665 1 0.0156591 0.0755396 0.150847 0.0843293 GeneID:10242,Genbank:NM_181361.2,HGNC:HGNC:6286,MIM:605214 potassium calcium-activated channel subfamily M regulatory beta subunit 2 GO:0001508,GO:0005513,GO:0005886,GO:0005887,GO:0006813,GO:0007268,GO:0008076,GO:0008200,GO:0015269,GO:0015459,GO:0019228,GO:0019229 action potential|detection of calcium ion|plasma membrane|integral component of plasma membrane|potassium ion transport|chemical synaptic transmission|voltage-gated potassium channel complex|ion channel inhibitor activity|calcium-activated potassium channel activity|potassium channel regulator activity|neuronal action potential|regulation of vasoconstriction hsa04022,hsa04270,hsa04911 cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion KCNMB3 28.4378571098552 26.8284485929612 30.0472656267492 1.11997775505485 0.163470077826846 0.775265228801191 1 0.201381 0.150872 0.243928 0.189173 GeneID:27094,Genbank:NM_001163677.1,HGNC:HGNC:6287,MIM:605222 potassium calcium-activated channel subfamily M regulatory beta subunit 3 GO:0001508,GO:0005513,GO:0005886,GO:0005887,GO:0006813,GO:0007268,GO:0008076,GO:0015269,GO:0015459,GO:0019228 action potential|detection of calcium ion|plasma membrane|integral component of plasma membrane|potassium ion transport|chemical synaptic transmission|voltage-gated potassium channel complex|calcium-activated potassium channel activity|potassium channel regulator activity|neuronal action potential hsa04022,hsa04270,hsa04911 cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion KCNMB4 216.950201642435 222.094329632636 211.806073652234 0.953676187962929 -0.06842859943371 0.765741506721833 1 0.837512 0.932981 0.943897 0.721772 GeneID:27345,Genbank:XM_011538188.2,HGNC:HGNC:6289,MIM:605223 potassium calcium-activated channel subfamily M regulatory beta subunit 4 GO:0001508,GO:0005513,GO:0005886,GO:0005887,GO:0006813,GO:0007268,GO:0008076,GO:0015269,GO:0015459,GO:0019228,GO:0019229,GO:0046928 action potential|detection of calcium ion|plasma membrane|integral component of plasma membrane|potassium ion transport|chemical synaptic transmission|voltage-gated potassium channel complex|calcium-activated potassium channel activity|potassium channel regulator activity|neuronal action potential|regulation of vasoconstriction|regulation of neurotransmitter secretion hsa04022,hsa04270,hsa04911 cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion KCNN1 3.7788519591752 4.65077399104097 2.90692992730943 0.625042182851543 -0.677974537213234 0.741135810581642 1 0.0720009 0.0606544 0.032938 0.0307833 GeneID:3780,Genbank:NM_002248.4,HGNC:HGNC:6290,MIM:602982 potassium calcium-activated channel subfamily N member 1 GO:0005516,GO:0005886,GO:0006813,GO:0007268,GO:0008076,GO:0015269,GO:0016286,GO:0043025,GO:0046982 calmodulin binding|plasma membrane|potassium ion transport|chemical synaptic transmission|voltage-gated potassium channel complex|calcium-activated potassium channel activity|small conductance calcium-activated potassium channel activity|neuronal cell body|protein heterodimerization activity hsa04911 Insulin secretion KCNN2 13.6431366618292 13.7121905996982 13.5740827239602 0.989928095388271 -0.0146043577700419 1 1 0.0820344 0.139864 0.163786 0.0718916 GeneID:3781,Genbank:XM_011543387.1,HGNC:HGNC:6291,MIM:605879 potassium calcium-activated channel subfamily N member 2 GO:0005516,GO:0005886,GO:0006813,GO:0009986,GO:0015269,GO:0016021,GO:0016286,GO:0019904,GO:0030018,GO:0042803,GO:0043025,GO:0043197,GO:0051393,GO:0071805,GO:0098914,GO:1901379 calmodulin binding|plasma membrane|potassium ion transport|cell surface|calcium-activated potassium channel activity|integral component of membrane|small conductance calcium-activated potassium channel activity|protein domain specific binding|Z disc|protein homodimerization activity|neuronal cell body|dendritic spine|alpha-actinin binding|potassium ion transmembrane transport|membrane repolarization during atrial cardiac muscle cell action potential|regulation of potassium ion transmembrane transport hsa04726,hsa04911,hsa04976 Serotonergic synapse|Insulin secretion|Bile secretion KCNN3 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00320659 0 0 0 GeneID:3782,Genbank:NM_002249.5,HGNC:HGNC:6292,MIM:602983 potassium calcium-activated channel subfamily N member 3 GO:0005516,GO:0005886,GO:0016021,GO:0016286,GO:0043025,GO:1903955 calmodulin binding|plasma membrane|integral component of membrane|small conductance calcium-activated potassium channel activity|neuronal cell body|positive regulation of protein targeting to mitochondrion hsa04911 Insulin secretion KCNN4 1032.39811659709 994.827656958914 1069.96857623527 1.07553159459404 0.105049905695087 0.576965972484452 1 14.1556 14.8487 14.832 17.3663 GeneID:3783,Genbank:XM_005258882.2,HGNC:HGNC:6293,MIM:602754 potassium calcium-activated channel subfamily N member 4 GO:0002376,GO:0005267,GO:0005516,GO:0005886,GO:0006813,GO:0006816,GO:0006884,GO:0006952,GO:0008076,GO:0015269,GO:0016286,GO:0019903,GO:0030322,GO:0031982,GO:0043025,GO:0045332,GO:0046541,GO:0050714,GO:0050862 immune system process|potassium channel activity|calmodulin binding|plasma membrane|potassium ion transport|calcium ion transport|cell volume homeostasis|defense response|voltage-gated potassium channel complex|calcium-activated potassium channel activity|small conductance calcium-activated potassium channel activity|protein phosphatase binding|stabilization of membrane potential|vesicle|neuronal cell body|phospholipid translocation|saliva secretion|positive regulation of protein secretion|positive regulation of T cell receptor signaling pathway hsa04911,hsa04970,hsa04974 Insulin secretion|Salivary secretion|Protein digestion and absorption KCNQ2 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.00426544 0 0 GeneID:3785,Genbank:XM_011528811.2,HGNC:HGNC:6296,MIM:602235 potassium voltage-gated channel subfamily Q member 2 GO:0005249,GO:0005516,GO:0005886,GO:0005887,GO:0007268,GO:0007399,GO:0008076,GO:0016021,GO:0030506,GO:0033268,GO:0034765,GO:0043194,GO:0071805 voltage-gated potassium channel activity|calmodulin binding|plasma membrane|integral component of plasma membrane|chemical synaptic transmission|nervous system development|voltage-gated potassium channel complex|integral component of membrane|ankyrin binding|node of Ranvier|regulation of ion transmembrane transport|axon initial segment|potassium ion transmembrane transport hsa04725 Cholinergic synapse KCNQ3 2.21051864027483 1.02816907859967 3.39286820195 3.29991270168422 1.72242785886104 0.509773552864233 1 0.00157902 0.00148649 0.00604915 0.00422768 GeneID:3786,Genbank:NM_004519.3,HGNC:HGNC:6297,MIM:602232 potassium voltage-gated channel subfamily Q member 3 GO:0005249,GO:0005516,GO:0005886,GO:0005887,GO:0007268,GO:0008076,GO:0009986,GO:0016021,GO:0033268,GO:0034765,GO:0043194,GO:0060081,GO:0071805 voltage-gated potassium channel activity|calmodulin binding|plasma membrane|integral component of plasma membrane|chemical synaptic transmission|voltage-gated potassium channel complex|cell surface|integral component of membrane|node of Ranvier|regulation of ion transmembrane transport|axon initial segment|membrane hyperpolarization|potassium ion transmembrane transport hsa04725 Cholinergic synapse KCNQ4 1.29721791692082 2.59443583384164 0 0 -Inf 0.298334034769393 1 0.0374865 0.0213844 0 0 GeneID:9132,Genbank:NM_004700.3,HGNC:HGNC:6298,MIM:603537 potassium voltage-gated channel subfamily Q member 4 hsa04725 Cholinergic synapse KCNQ5 151.884113279221 156.425778771204 147.342447787238 0.941932007273225 -0.0863051712595271 0.756547982263964 1 0.741268 0.731667 0.730471 0.620377 GeneID:56479,Genbank:NM_001160133.1,HGNC:HGNC:6299,MIM:607357 potassium voltage-gated channel subfamily Q member 5 GO:0005249,GO:0005886,GO:0005887,GO:0008076,GO:0016021,GO:0030118,GO:0034765,GO:0071805 voltage-gated potassium channel activity|plasma membrane|integral component of plasma membrane|voltage-gated potassium channel complex|integral component of membrane|clathrin coat|regulation of ion transmembrane transport|potassium ion transmembrane transport hsa04725 Cholinergic synapse KCNRG 1.4622745707901 1.47021420587209 1.45433493570811 0.989199349250911 -0.0156668042423989 1 1 1.35415e-06 0.0968132 0.0717244 0.0311915 GeneID:283518,Genbank:NM_199464.2,HGNC:HGNC:18893,MIM:607947 potassium channel regulator GO:0005783,GO:0042802,GO:0051260,GO:1902260 endoplasmic reticulum|identical protein binding|protein homooligomerization|negative regulation of delayed rectifier potassium channel activity KCNS3 23.3324443774949 18.0649982875216 28.5998904674683 1.58316596615587 0.662812503737386 0.260419061142431 1 0.289473 0.194271 0.519496 0.295241 GeneID:3790,Genbank:NM_001282428.1,HGNC:HGNC:6302,MIM:603888 potassium voltage-gated channel modifier subfamily S member 3 GO:0005251,GO:0005794,GO:0005829,GO:0005886,GO:0006813,GO:0008076,GO:0015459,GO:0016021,GO:0034765,GO:0050796,GO:0051260 delayed rectifier potassium channel activity|Golgi apparatus|cytosol|plasma membrane|potassium ion transport|voltage-gated potassium channel complex|potassium channel regulator activity|integral component of membrane|regulation of ion transmembrane transport|regulation of insulin secretion|protein homooligomerization KCNT2 7.18139974031398 6.12098819691306 8.24181128371491 1.34648377330174 0.429196843788215 0.753593987249719 1 0.00631032 0.00939267 0.0338022 0.00858877 GeneID:343450,Genbank:NM_001287820.2,HGNC:HGNC:18866,MIM:610044 potassium sodium-activated channel subfamily T member 2 GO:0005249,GO:0005524,GO:0008076,GO:0015269 voltage-gated potassium channel activity|ATP binding|voltage-gated potassium channel complex|calcium-activated potassium channel activity KCNU1 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.00967412 0 GeneID:157855,Genbank:NM_001031836.2,HGNC:HGNC:18867,MIM:615215 potassium calcium-activated channel subfamily U member 1 GO:0005249,GO:0005267,GO:0005886,GO:0008076,GO:0034765,GO:0035036,GO:0060072 voltage-gated potassium channel activity|potassium channel activity|plasma membrane|voltage-gated potassium channel complex|regulation of ion transmembrane transport|sperm-egg recognition|large conductance calcium-activated potassium channel activity hsa04022,hsa04270,hsa04911 cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Insulin secretion KCP 7.73045945337148 5.28492421705316 10.1759946896898 1.92547599014842 0.945215133464803 0.372050821935797 1 0.0263931 0.00743071 0.0403014 0.0377314 GeneID:375616,Genbank:XM_017012188.1,HGNC:HGNC:17585,MIM:609344 kielin/chordin-like protein GO:0005576 extracellular region KCTD1 448.925704333332 398.651253503669 499.200155162994 1.25222271540757 0.324491177157774 0.0698686862640807 0.92021045003939 3.61509 3.38553 4.9035 4.05292 GeneID:284252,Genbank:NM_001258222.2,HGNC:HGNC:18249,MIM:613420 potassium channel tetramerization domain containing 1 GO:0000122,GO:0003714,GO:0005634,GO:0005654,GO:0006351,GO:0008134,GO:0042802,GO:0045892,GO:0051260 negative regulation of transcription from RNA polymerase II promoter|transcription corepressor activity|nucleus|nucleoplasm|transcription, DNA-templated|transcription factor binding|identical protein binding|negative regulation of transcription, DNA-templated|protein homooligomerization KCTD10 1583.11754153277 1640.16000308478 1526.07507998076 0.930442808695826 -0.104010619666515 0.487643040617245 1 17.61 15.6757 15.8738 15.6794 GeneID:83892,Genbank:NM_001317399.1,HGNC:HGNC:23236,MIM:613421 potassium channel tetramerization domain containing 10 GO:0005112,GO:0005654,GO:0005829,GO:0006511,GO:0016567,GO:0031463,GO:0043161,GO:0051260 Notch binding|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|Cul3-RING ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|protein homooligomerization KCTD11 380.329599595051 370.535904149322 390.123295040779 1.05286232905398 0.0743168037178631 0.726147857850845 1 4.88652 5.89237 5.84201 5.75225 GeneID:147040,Genbank:NM_001002914.2,HGNC:HGNC:21302,MIM:609848 potassium channel tetramerization domain containing 11 GO:0005737,GO:0007049,GO:0007406,GO:0016567,GO:0016740,GO:0040008,GO:0042802,GO:0045666,GO:0045879,GO:0051260 cytoplasm|cell cycle|negative regulation of neuroblast proliferation|protein ubiquitination|transferase activity|regulation of growth|identical protein binding|positive regulation of neuron differentiation|negative regulation of smoothened signaling pathway|protein homooligomerization KCTD12 772.195011728772 927.418317552007 616.971705905536 0.665257192174165 -0.588015892408884 0.000243880134768049 0.0409556523973718 7.60418 7.41706 5.49499 4.55504 GeneID:115207,Genbank:NM_138444.3,HGNC:HGNC:14678,MIM:610521 potassium channel tetramerization domain containing 12 GO:0003723,GO:0030054,GO:0042734,GO:0042802,GO:0045211,GO:0051260,GO:0070062 RNA binding|cell junction|presynaptic membrane|identical protein binding|postsynaptic membrane|protein homooligomerization|extracellular exosome KCTD13 251.779884398795 245.261955693579 258.29781310401 1.0531507521155 0.074711964153329 0.740717087560801 1 1.93263 2.19737 2.18016 2.07818 GeneID:253980,Genbank:NM_178863.4,HGNC:HGNC:22234,MIM:608947 potassium channel tetramerization domain containing 13 GO:0005634,GO:0006260,GO:0016477,GO:0016567,GO:0016604,GO:0017049,GO:0019904,GO:0031463,GO:0035024,GO:0042802,GO:0043149,GO:0043161,GO:0045740,GO:0050806,GO:0051260 nucleus|DNA replication|cell migration|protein ubiquitination|nuclear body|GTP-Rho binding|protein domain specific binding|Cul3-RING ubiquitin ligase complex|negative regulation of Rho protein signal transduction|identical protein binding|stress fiber assembly|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of DNA replication|positive regulation of synaptic transmission|protein homooligomerization KCTD15 406.996781269203 405.944489603236 408.049072935169 1.00518441162729 0.00746020322895183 0.971933268195983 1 2.79478 2.80607 2.87211 2.89869 GeneID:79047,Genbank:XM_017027284.1,HGNC:HGNC:23297,MIM:615240 potassium channel tetramerization domain containing 15 GO:0007275,GO:0042802,GO:0051260 multicellular organism development|identical protein binding|protein homooligomerization KCTD16 7.92453234395343 5.18887166768327 10.6601930202236 2.05443373876755 1.03874080030696 0.330695874429141 1 0.0108271 0.0105646 0.0236157 0.0317515 GeneID:57528,Genbank:XM_011537671.2,HGNC:HGNC:29244,MIM:613423 potassium channel tetramerization domain containing 16 GO:0008277,GO:0030054,GO:0042734,GO:0043235,GO:0045211,GO:0051260 regulation of G-protein coupled receptor protein signaling pathway|cell junction|presynaptic membrane|receptor complex|postsynaptic membrane|protein homooligomerization KCTD17 551.295787066929 507.954759448667 594.636814685191 1.17064916436773 0.227308774674344 0.188316351750407 1 6.65066 6.63035 7.76331 7.81655 GeneID:79734,Genbank:XM_005261741.3,HGNC:HGNC:25705,MIM:616386 potassium channel tetramerization domain containing 17 GO:0005737,GO:0005783,GO:0030030,GO:0031463,GO:0032403,GO:0032469,GO:0042802,GO:0043161,GO:0045724,GO:0051260,GO:0097602 cytoplasm|endoplasmic reticulum|cell projection organization|Cul3-RING ubiquitin ligase complex|protein complex binding|endoplasmic reticulum calcium ion homeostasis|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of cilium assembly|protein homooligomerization|cullin family protein binding KCTD18 241.78841630444 223.804675211933 259.772157396947 1.16070925306165 0.215006635685777 0.315278895949668 1 3.09824 3.25831 4.06359 3.54608 GeneID:130535,Genbank:NM_001321548.1,HGNC:HGNC:26446 potassium channel tetramerization domain containing 18 GO:0051260 protein homooligomerization KCTD19 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0108864 0 GeneID:146212,Genbank:NM_001100915.2,HGNC:HGNC:24753 potassium channel tetramerization domain containing 19 GO:0051260 protein homooligomerization KCTD2 1678.5175110025 1539.15152735519 1817.8834946498 1.18109455913906 0.240124472389529 0.0941875640397163 0.993092841119221 13.2438 13.1851 16.558 15.242 GeneID:23510,Genbank:NM_015353.2,HGNC:HGNC:21294,MIM:613422 potassium channel tetramerization domain containing 2 GO:0031463,GO:0032403,GO:0043161,GO:0051260,GO:0097602 Cul3-RING ubiquitin ligase complex|protein complex binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein homooligomerization|cullin family protein binding KCTD20 3076.27194953287 3194.88897109899 2957.65492796674 0.925745762911239 -0.111312053613257 0.415258599398758 1 21.3246 21.7154 20.2873 19.6297 GeneID:222658,Genbank:NM_173562.4,HGNC:HGNC:21052,MIM:615932 potassium channel tetramerization domain containing 20 GO:0005737,GO:0042327 cytoplasm|positive regulation of phosphorylation KCTD21 265.681680338957 276.923474721213 254.439885956701 0.9188093794246 -0.122162510722364 0.568950037573959 1 1.26278 1.18325 1.22155 1.07612 GeneID:283219,Genbank:XM_005273925.3,HGNC:HGNC:27452 potassium channel tetramerization domain containing 21 GO:0006511,GO:0016567,GO:0040008,GO:0042802,GO:0042826,GO:0045879,GO:0051260,GO:0097602 ubiquitin-dependent protein catabolic process|protein ubiquitination|regulation of growth|identical protein binding|histone deacetylase binding|negative regulation of smoothened signaling pathway|protein homooligomerization|cullin family protein binding KCTD3 939.774139811997 990.155231655948 889.393047968045 0.898235973040927 -0.154833593780213 0.430244788243804 1 9.2348 8.2789 9.22453 6.79539 GeneID:51133,Genbank:NM_001319295.1,HGNC:HGNC:21305,MIM:613272 potassium channel tetramerization domain containing 3 GO:0005886,GO:0051260 plasma membrane|protein homooligomerization KCTD4 208.771199603907 227.571358948429 189.971040259384 0.834775699091531 -0.260539491646952 0.25193863363659 1 4.46274 4.43635 3.74789 3.67858 GeneID:386618,Genbank:NM_198404.2,HGNC:HGNC:23227 potassium channel tetramerization domain containing 4 GO:0051260 protein homooligomerization KCTD5 1140.12016523619 1073.063542481 1207.17678799138 1.12498164386454 0.169901461423065 0.257265280089903 1 22.2644 21.4501 25.142 25.3546 GeneID:54442,Genbank:NM_018992.3,HGNC:HGNC:21423,MIM:611285 potassium channel tetramerization domain containing 5 GO:0005634,GO:0005829,GO:0016032,GO:0031463,GO:0032403,GO:0042802,GO:0043161,GO:0051260,GO:0097602 nucleus|cytosol|viral process|Cul3-RING ubiquitin ligase complex|protein complex binding|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein homooligomerization|cullin family protein binding KCTD6 333.340754624232 358.455589888057 308.225919360406 0.85987198429982 -0.217806204099429 0.368663879188556 1 4.96032 3.96317 3.98341 3.75925 GeneID:200845,Genbank:NM_001128214.1,HGNC:HGNC:22235 potassium channel tetramerization domain containing 6 GO:0005829,GO:0006511,GO:0016567,GO:0030506,GO:0031430,GO:0033146,GO:0040008,GO:0042802,GO:0043687,GO:0045879,GO:0051260,GO:0097602 cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|ankyrin binding|M band|regulation of intracellular estrogen receptor signaling pathway|regulation of growth|identical protein binding|post-translational protein modification|negative regulation of smoothened signaling pathway|protein homooligomerization|cullin family protein binding KCTD7 854.595488946836 825.226768263799 883.964209629873 1.0711773340674 0.0991973389129117 0.533193870560713 1 7.02029 7.28538 7.98628 7.61236 GeneID:154881,Genbank:NM_153033.4,HGNC:HGNC:21957,MIM:611725 potassium channel tetramerization domain containing 7 GO:0005737,GO:0005829,GO:0005886,GO:0030007,GO:0032411,GO:0043687,GO:0051260,GO:0060081,GO:0090461 cytoplasm|cytosol|plasma membrane|cellular potassium ion homeostasis|positive regulation of transporter activity|post-translational protein modification|protein homooligomerization|membrane hyperpolarization|glutamate homeostasis KCTD9 1535.39118978513 1633.2607858378 1437.52159373245 0.880154355138728 -0.184171539472222 0.211207546204692 1 18.103 17.0745 17.4534 13.6588 GeneID:54793,Genbank:NM_017634.3,HGNC:HGNC:22401,MIM:617265 potassium channel tetramerization domain containing 9 GO:0005622,GO:0016567,GO:0035556,GO:0042802,GO:0043621,GO:0051260,GO:0097602 intracellular|protein ubiquitination|intracellular signal transduction|identical protein binding|protein self-association|protein homooligomerization|cullin family protein binding KDELC1 347.180678876459 362.895658470997 331.465699281921 0.913391195360392 -0.130695211971097 0.50946004408583 1 5.67848 5.5902 4.73068 5.02362 GeneID:79070,Genbank:NM_024089.2,HGNC:HGNC:19350,MIM:611613 KDEL motif containing 1 GO:0005788,GO:0006664,GO:0046527 endoplasmic reticulum lumen|glycolipid metabolic process|glucosyltransferase activity KDELC2 1181.02899439052 1140.12383830744 1221.9341504736 1.0717556369031 0.0999760050352321 0.683920826971763 1 9.97919 9.25552 12.3968 8.46161 GeneID:143888,Genbank:NM_153705.4,HGNC:HGNC:28496 KDEL motif containing 2 GO:0005788,GO:0006664,GO:0046527 endoplasmic reticulum lumen|glycolipid metabolic process|glucosyltransferase activity KDELR1 8419.78457212176 7892.88876787496 8946.68037636856 1.13351152404208 0.180799058563344 0.169425277076393 1 248.8 253.662 290.814 284.215 GeneID:10945,Genbank:NM_006801.2,HGNC:HGNC:6304,MIM:131235 KDEL endoplasmic reticulum protein retention receptor 1 GO:0000139,GO:0002369,GO:0005046,GO:0005789,GO:0005793,GO:0005801,GO:0006621,GO:0006886,GO:0006888,GO:0006890,GO:0016020,GO:0016021,GO:0030133,GO:0030217,GO:0030663,GO:0033116,GO:0070231 Golgi membrane|T cell cytokine production|KDEL sequence binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cis-Golgi network|protein retention in ER lumen|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|membrane|integral component of membrane|transport vesicle|T cell differentiation|COPI-coated vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|T cell apoptotic process hsa05110 Vibrio cholerae infection KDELR2 9018.82660669805 9103.86697770896 8933.78623568715 0.981317747454103 -0.0272077428954263 0.838868929689198 1 165.18 167.165 172.974 157.742 GeneID:11014,Genbank:NM_001100603.1,HGNC:HGNC:6305,MIM:609024 KDEL endoplasmic reticulum protein retention receptor 2 GO:0000139,GO:0005046,GO:0005783,GO:0005789,GO:0005794,GO:0005801,GO:0006621,GO:0006886,GO:0006890,GO:0016021,GO:0030133,GO:0070062 Golgi membrane|KDEL sequence binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cis-Golgi network|protein retention in ER lumen|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER|integral component of membrane|transport vesicle|extracellular exosome hsa05110 Vibrio cholerae infection KDELR3 811.111815971117 847.855279647245 774.368352294988 0.913326095719033 -0.130798040066336 0.42410653865509 1 16.2622 15.4601 13.7312 16.152 GeneID:11015,Genbank:NM_006855.3,HGNC:HGNC:6306 KDEL endoplasmic reticulum protein retention receptor 3 GO:0000139,GO:0005783,GO:0005789,GO:0006621,GO:0006890,GO:0015031,GO:0016021,GO:0030133,GO:0036498,GO:0046923 Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|protein retention in ER lumen|retrograde vesicle-mediated transport, Golgi to ER|protein transport|integral component of membrane|transport vesicle|IRE1-mediated unfolded protein response|ER retention sequence binding hsa05110 Vibrio cholerae infection KDM1A 3436.05686592301 3799.64551141519 3072.46822043082 0.808619701811728 -0.306466739954721 0.0234309642611374 0.617220926984171 27.4222 27.8523 22.4795 22.2894 GeneID:23028,Genbank:XM_006710474.3,HGNC:HGNC:29079,MIM:609132 lysine demethylase 1A GO:0000122,GO:0000380,GO:0000784,GO:0000790,GO:0002039,GO:0003682,GO:0004407,GO:0005634,GO:0005654,GO:0005667,GO:0006351,GO:0006357,GO:0006482,GO:0007596,GO:0008134,GO:0010569,GO:0010976,GO:0016491,GO:0019899,GO:0021987,GO:0030374,GO:0032091,GO:0032451,GO:0032452,GO:0032453,GO:0032454,GO:0033169,GO:0033184,GO:0034644,GO:0034648,GO:0034720,GO:0035563,GO:0042162,GO:0042551,GO:0043234,GO:0043392,GO:0043426,GO:0043433,GO:0043518,GO:0044212,GO:0045793,GO:0045892,GO:0045944,GO:0046098,GO:0050660,GO:0050681,GO:0051091,GO:0055001,GO:0060992,GO:0061752,GO:0071320,GO:0071480,GO:1902166,GO:1903827,GO:1990391 negative regulation of transcription from RNA polymerase II promoter|alternative mRNA splicing, via spliceosome|nuclear chromosome, telomeric region|nuclear chromatin|p53 binding|chromatin binding|histone deacetylase activity|nucleus|nucleoplasm|transcription factor complex|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|protein demethylation|blood coagulation|transcription factor binding|regulation of double-strand break repair via homologous recombination|positive regulation of neuron projection development|oxidoreductase activity|enzyme binding|cerebral cortex development|ligand-dependent nuclear receptor transcription coactivator activity|negative regulation of protein binding|demethylase activity|histone demethylase activity|histone demethylase activity (H3-K4 specific)|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|positive regulation of histone ubiquitination|cellular response to UV|histone demethylase activity (H3-dimethyl-K4 specific)|histone H3-K4 demethylation|positive regulation of chromatin binding|telomeric DNA binding|neuron maturation|protein complex|negative regulation of DNA binding|MRF binding|negative regulation of DNA binding transcription factor activity|negative regulation of DNA damage response, signal transduction by p53 class mediator|transcription regulatory region DNA binding|positive regulation of cell size|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|guanine metabolic process|flavin adenine dinucleotide binding|androgen receptor binding|positive regulation of DNA binding transcription factor activity|muscle cell development|response to fungicide|telomeric repeat-containing RNA binding|cellular response to cAMP|cellular response to gamma radiation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of cellular protein localization|DNA repair complex hsa04714 Thermogenesis KDM1B 684.93962936586 697.21430515016 672.664953581561 0.964789374820255 -0.0517140758941149 0.760989452463349 1 5.30805 5.37788 5.18716 5.09949 GeneID:221656,Genbank:NM_153042.3,HGNC:HGNC:21577,MIM:613081 lysine demethylase 1B GO:0000786,GO:0003677,GO:0005634,GO:0005654,GO:0006349,GO:0006351,GO:0006355,GO:0007275,GO:0008270,GO:0016579,GO:0032452,GO:0034648,GO:0034649,GO:0034720,GO:0042393,GO:0043046,GO:0044030,GO:0071949 nucleosome|DNA binding|nucleus|nucleoplasm|regulation of gene expression by genetic imprinting|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|zinc ion binding|protein deubiquitination|histone demethylase activity|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|histone H3-K4 demethylation|histone binding|DNA methylation involved in gamete generation|regulation of DNA methylation|FAD binding KDM2A 1532.39550375743 1251.66597885327 1813.12502866159 1.44856939414675 0.534628798997916 0.000199338968683224 0.0354734769158946 6.10904 5.42836 9.23499 7.60237 GeneID:22992,Genbank:NM_012308.2,HGNC:HGNC:13606,MIM:605657 lysine demethylase 2A GO:0003677,GO:0005654,GO:0006303,GO:0006351,GO:0006355,GO:0008270,GO:0032452,GO:0051864,GO:0070544 DNA binding|nucleoplasm|double-strand break repair via nonhomologous end joining|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|histone demethylase activity|histone demethylase activity (H3-K36 specific)|histone H3-K36 demethylation KDM2B 743.552281589853 632.68080157266 854.423761607046 1.35048156903639 0.433473950516077 0.00753453592082582 0.341216961574625 2.17436 2.4789 3.40169 3.04252 GeneID:84678,Genbank:XM_011538867.3,HGNC:HGNC:13610,MIM:609078 lysine demethylase 2B GO:0000122,GO:0000978,GO:0003677,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0007283,GO:0008270,GO:0019843,GO:0021555,GO:0021592,GO:0021670,GO:0021678,GO:0021993,GO:0030307,GO:0030900,GO:0030901,GO:0030902,GO:0032452,GO:0035518,GO:0043524,GO:0048596,GO:0051864,GO:1902459,GO:2000178 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|spermatogenesis|zinc ion binding|rRNA binding|midbrain-hindbrain boundary morphogenesis|fourth ventricle development|lateral ventricle development|third ventricle development|initiation of neural tube closure|positive regulation of cell growth|forebrain development|midbrain development|hindbrain development|histone demethylase activity|histone H2A monoubiquitination|negative regulation of neuron apoptotic process|embryonic camera-type eye morphogenesis|histone demethylase activity (H3-K36 specific)|positive regulation of stem cell population maintenance|negative regulation of neural precursor cell proliferation KDM3A 472.805216609498 464.848093386635 480.762339832361 1.03423536994588 0.0485645496873182 0.787609650679221 1 2.56164 2.67286 2.85472 2.53796 GeneID:55818,Genbank:XM_024452995.1,HGNC:HGNC:20815,MIM:611512 lysine demethylase 3A GO:0000785,GO:0000976,GO:0000979,GO:0003700,GO:0005506,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0007290,GO:0009755,GO:0016020,GO:0030521,GO:0031490,GO:0032452,GO:0032454,GO:0033169,GO:0036123,GO:0045893,GO:0045944,GO:0046293,GO:0050681,GO:0051213,GO:0051573,GO:1990830,GO:2000036,GO:2000736 chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|DNA binding transcription factor activity|iron ion binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|spermatid nucleus elongation|hormone-mediated signaling pathway|membrane|androgen receptor signaling pathway|chromatin DNA binding|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|histone H3-K9 dimethylation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|formaldehyde biosynthetic process|androgen receptor binding|dioxygenase activity|negative regulation of histone H3-K9 methylation|cellular response to leukemia inhibitory factor|regulation of stem cell population maintenance|regulation of stem cell differentiation hsa04714 Thermogenesis KDM3B 3219.9594492299 3150.58164816984 3289.33725028996 1.04404126526945 0.0621787349184053 0.646791857727288 1 13.4991 13.5137 15.5543 13.2433 GeneID:51780,Genbank:NM_016604.3,HGNC:HGNC:1337,MIM:609373 lysine demethylase 3B GO:0000785,GO:0000976,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0016209,GO:0031490,GO:0032452,GO:0032454,GO:0033169,GO:0046872,GO:0051213,GO:0072718 chromatin|transcription regulatory region sequence-specific DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|antioxidant activity|chromatin DNA binding|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|metal ion binding|dioxygenase activity|response to cisplatin hsa04714 Thermogenesis KDM4A 1624.01011120339 1703.58214469199 1544.4380777148 0.906582686679921 -0.141489485041716 0.320281274897088 1 12.0694 12.3715 10.9826 11.4074 GeneID:9682,Genbank:NM_014663.2,HGNC:HGNC:22978,MIM:609764 lysine demethylase 4A GO:0001650,GO:0005634,GO:0005654,GO:0005721,GO:0005829,GO:0006351,GO:0008270,GO:0010507,GO:0010628,GO:0010629,GO:0014898,GO:0016032,GO:0016577,GO:0031625,GO:0031667,GO:0032452,GO:0032454,GO:0033169,GO:0035064,GO:0045666,GO:0045892,GO:0048712,GO:0051864,GO:0060548,GO:0070544,GO:1900113 fibrillar center|nucleus|nucleoplasm|pericentric heterochromatin|cytosol|transcription, DNA-templated|zinc ion binding|negative regulation of autophagy|positive regulation of gene expression|negative regulation of gene expression|cardiac muscle hypertrophy in response to stress|viral process|histone demethylation|ubiquitin protein ligase binding|response to nutrient levels|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|methylated histone binding|positive regulation of neuron differentiation|negative regulation of transcription, DNA-templated|negative regulation of astrocyte differentiation|histone demethylase activity (H3-K36 specific)|negative regulation of cell death|histone H3-K36 demethylation|negative regulation of histone H3-K9 trimethylation KDM4B 1339.54578346682 1162.16927674213 1516.9222901915 1.30525072426957 0.384326959222004 0.00934256736354794 0.378811541505276 4.27625 4.46585 5.94986 5.54513 GeneID:23030,Genbank:XM_005259521.4,HGNC:HGNC:29136,MIM:609765 lysine demethylase 4B GO:0005654,GO:0006351,GO:0006355,GO:0032452,GO:0032454,GO:0033169,GO:0046872,GO:0051864,GO:0070544 nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|metal ion binding|histone demethylase activity (H3-K36 specific)|histone H3-K36 demethylation KDM4C 539.000355893709 530.81359355043 547.187118236988 1.0308460915197 0.0438289499937988 0.779179399619451 1 1.47442 1.38173 1.65464 1.33304 GeneID:23081,Genbank:NM_001146696.1,HGNC:HGNC:17071,MIM:605469 lysine demethylase 4C KDM4D 44.9890344249774 44.9032555355907 45.0748133143641 1.00382060892305 0.00550147074171355 1 1 0.50023 0.62931 0.632799 0.51679 GeneID:55693,Genbank:NM_018039.2,HGNC:HGNC:25498,MIM:609766 lysine demethylase 4D GO:0000724,GO:0001932,GO:0005654,GO:0006351,GO:0006355,GO:0032452,GO:0032454,GO:0033169,GO:0035563,GO:0035861,GO:0046872,GO:0051213,GO:0071479,GO:0072562,GO:2001034 double-strand break repair via homologous recombination|regulation of protein phosphorylation|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|positive regulation of chromatin binding|site of double-strand break|metal ion binding|dioxygenase activity|cellular response to ionizing radiation|blood microparticle|positive regulation of double-strand break repair via nonhomologous end joining KDM5A 827.472442246889 815.040113026318 839.90477146746 1.03050728184263 0.0433546993857879 0.769123513688242 1 2.60829 2.47524 2.87276 2.44422 GeneID:5927,Genbank:NM_001042603.2,HGNC:HGNC:9886,MIM:180202 lysine demethylase 5A KDM5B 1165.08721873565 1160.73728015583 1169.43715731546 1.00749513030068 0.0107728655442739 0.956911351613045 1 3.81975 4.15971 4.27759 3.91721 GeneID:10765,Genbank:NM_001347591.1,HGNC:HGNC:18039,MIM:605393 lysine demethylase 5B GO:0003677,GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006357,GO:0007338,GO:0008270,GO:0009791,GO:0010628,GO:0032452,GO:0032453,GO:0033601,GO:0034647,GO:0034648,GO:0034720,GO:0042393,GO:0044344,GO:0045892,GO:0048511,GO:0051213,GO:0060444,GO:0060763,GO:0060992,GO:0061038,GO:0070306,GO:1990830,GO:1990837,GO:2000864 DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|single fertilization|zinc ion binding|post-embryonic development|positive regulation of gene expression|histone demethylase activity|histone demethylase activity (H3-K4 specific)|positive regulation of mammary gland epithelial cell proliferation|histone demethylase activity (H3-trimethyl-K4 specific)|histone demethylase activity (H3-dimethyl-K4 specific)|histone H3-K4 demethylation|histone binding|cellular response to fibroblast growth factor stimulus|negative regulation of transcription, DNA-templated|rhythmic process|dioxygenase activity|branching involved in mammary gland duct morphogenesis|mammary duct terminal end bud growth|response to fungicide|uterus morphogenesis|lens fiber cell differentiation|cellular response to leukemia inhibitory factor|sequence-specific double-stranded DNA binding|regulation of estradiol secretion KDM5C 2500.23879661517 2534.70938708949 2465.76820614085 0.972801149788693 -0.039783160931661 0.763435699248144 1 10.0692 10.5396 10.248 10.0453 GeneID:8242,Genbank:XM_011530827.3,HGNC:HGNC:11114,MIM:314690 lysine demethylase 5C GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0008270,GO:0009636,GO:0032452,GO:0032453,GO:0034720,GO:0045892,GO:0048511,GO:0051213 DNA binding|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|zinc ion binding|response to toxic substance|histone demethylase activity|histone demethylase activity (H3-K4 specific)|histone H3-K4 demethylation|negative regulation of transcription, DNA-templated|rhythmic process|dioxygenase activity KDM6A 213.902969094733 224.717174430947 203.08876375852 0.903752747304709 -0.145999967189465 0.599689356524276 1 1.33048 1.10392 1.39636 0.911099 GeneID:7403,Genbank:NM_001291415.1,HGNC:HGNC:12637,MIM:300128 lysine demethylase 6A GO:0000978,GO:0001701,GO:0001843,GO:0003007,GO:0003016,GO:0005634,GO:0005654,GO:0006338,GO:0010628,GO:0031490,GO:0032452,GO:0032525,GO:0035097,GO:0035264,GO:0042802,GO:0044666,GO:0046872,GO:0048333,GO:0048570,GO:0051213,GO:0051568,GO:0060070,GO:0071558,GO:0072358 RNA polymerase II proximal promoter sequence-specific DNA binding|in utero embryonic development|neural tube closure|heart morphogenesis|respiratory system process|nucleus|nucleoplasm|chromatin remodeling|positive regulation of gene expression|chromatin DNA binding|histone demethylase activity|somite rostral/caudal axis specification|histone methyltransferase complex|multicellular organism growth|identical protein binding|MLL3/4 complex|metal ion binding|mesodermal cell differentiation|notochord morphogenesis|dioxygenase activity|histone H3-K4 methylation|canonical Wnt signaling pathway|histone demethylase activity (H3-K27 specific)|cardiovascular system development hsa05202 Transcriptional misregulation in cancer KDM6B 421.570736410508 386.630808173906 456.51066464711 1.18074052816239 0.239691962312143 0.196573938441307 1 1.35863 1.50097 1.73726 1.7653 GeneID:23135,Genbank:XM_005256549.3,HGNC:HGNC:29012,MIM:611577 lysine demethylase 6B GO:0002437,GO:0003682,GO:0005634,GO:0005654,GO:0006338,GO:0008013,GO:0014823,GO:0021766,GO:0032452,GO:0043565,GO:0045165,GO:0045446,GO:0045944,GO:0046872,GO:0048333,GO:0051213,GO:0055007,GO:0060992,GO:0070301,GO:0071557,GO:0071558 inflammatory response to antigenic stimulus|chromatin binding|nucleus|nucleoplasm|chromatin remodeling|beta-catenin binding|response to activity|hippocampus development|histone demethylase activity|sequence-specific DNA binding|cell fate commitment|endothelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|mesodermal cell differentiation|dioxygenase activity|cardiac muscle cell differentiation|response to fungicide|cellular response to hydrogen peroxide|histone H3-K27 demethylation|histone demethylase activity (H3-K27 specific) KDM7A 61.6863397299047 71.020101662531 52.3525777972785 0.737151546840137 -0.439966849516641 0.575344514097054 1 0.388962 0.198883 0.264764 0.158792 GeneID:80853,Genbank:NM_030647.1,HGNC:HGNC:22224 lysine demethylase 7A GO:0005506,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0008270,GO:0016706,GO:0030901,GO:0032452,GO:0032454,GO:0033169,GO:0035064,GO:0035574,GO:0035575,GO:0045893,GO:0051864,GO:0070544,GO:0071557,GO:0071558 iron ion binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|zinc ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|midbrain development|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|methylated histone binding|histone H4-K20 demethylation|histone demethylase activity (H4-K20 specific)|positive regulation of transcription, DNA-templated|histone demethylase activity (H3-K36 specific)|histone H3-K36 demethylation|histone H3-K27 demethylation|histone demethylase activity (H3-K27 specific) KDM8 70.8684092132772 64.1885280004517 77.5482904261026 1.20813317958556 0.272779500140663 0.435789738887715 1 0.561415 0.534805 0.788873 0.700184 GeneID:79831,Genbank:XM_017023676.1,HGNC:HGNC:25840,MIM:611917 lysine demethylase 8 GO:0000086,GO:0003682,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006351,GO:0008233,GO:0032452,GO:0045893,GO:0046872,GO:0051864,GO:0070544 G2/M transition of mitotic cell cycle|chromatin binding|nucleus|nucleoplasm|chromosome|cytosol|transcription, DNA-templated|peptidase activity|histone demethylase activity|positive regulation of transcription, DNA-templated|metal ion binding|histone demethylase activity (H3-K36 specific)|histone H3-K36 demethylation KDR 353.367197844064 368.440331371691 338.294064316437 0.918178699538619 -0.123153130955627 0.523821063381023 1 1.93273 2.00686 2.00862 1.66878 GeneID:3791,Genbank:NM_002253.3,HGNC:HGNC:6307,MIM:191306 kinase insert domain receptor GO:0001525,GO:0001570,GO:0001934,GO:0001938,GO:0002042,GO:0003158,GO:0004713,GO:0004714,GO:0004716,GO:0005021,GO:0005178,GO:0005524,GO:0005576,GO:0005634,GO:0005768,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0007169,GO:0008284,GO:0008360,GO:0010595,GO:0010629,GO:0014068,GO:0016032,GO:0016239,GO:0018108,GO:0019838,GO:0030054,GO:0030198,GO:0030335,GO:0035162,GO:0035584,GO:0035924,GO:0038033,GO:0038083,GO:0038085,GO:0042802,GO:0043066,GO:0043410,GO:0043491,GO:0043536,GO:0045121,GO:0045766,GO:0046777,GO:0048010,GO:0050927,GO:0051770,GO:0051879,GO:0051894,GO:0051901,GO:0070371,GO:0070374,GO:0090141,GO:0097443,GO:1904881,GO:2000352,GO:2001214 angiogenesis|vasculogenesis|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|cell migration involved in sprouting angiogenesis|endothelium development|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|signal transducer, downstream of receptor, with protein tyrosine kinase activity|vascular endothelial growth factor-activated receptor activity|integrin binding|ATP binding|extracellular region|nucleus|endosome|early endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of cell proliferation|regulation of cell shape|positive regulation of endothelial cell migration|negative regulation of gene expression|positive regulation of phosphatidylinositol 3-kinase signaling|viral process|positive regulation of macroautophagy|peptidyl-tyrosine phosphorylation|growth factor binding|cell junction|extracellular matrix organization|positive regulation of cell migration|embryonic hemopoiesis|calcium-mediated signaling using intracellular calcium source|cellular response to vascular endothelial growth factor stimulus|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|peptidyl-tyrosine autophosphorylation|vascular endothelial growth factor binding|identical protein binding|negative regulation of apoptotic process|positive regulation of MAPK cascade|protein kinase B signaling|positive regulation of blood vessel endothelial cell migration|membrane raft|positive regulation of angiogenesis|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|Hsp90 protein binding|positive regulation of focal adhesion assembly|positive regulation of mitochondrial depolarization|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of mitochondrial fission|sorting endosome|cellular response to hydrogen sulfide|negative regulation of endothelial cell apoptotic process|positive regulation of vasculogenesis hsa01521,hsa04010,hsa04014,hsa04015,hsa04151,hsa04370,hsa04510,hsa05205,hsa05418 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|VEGF signaling pathway|Focal adhesion|Proteoglycans in cancer|Fluid shear stress and atherosclerosis KDSR 424.605753234574 434.800867388928 414.41063908022 0.953104444268579 -0.0692937768990939 0.71835012120316 1 3.24407 3.69372 3.66232 2.82385 GeneID:2531,Genbank:XM_005266677.3,HGNC:HGNC:4021,MIM:136440 3-ketodihydrosphingosine reductase GO:0005615,GO:0005783,GO:0005789,GO:0006666,GO:0016020,GO:0016021,GO:0030148,GO:0047560 extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|3-keto-sphinganine metabolic process|membrane|integral component of membrane|sphingolipid biosynthetic process|3-dehydrosphinganine reductase activity hsa00600 Sphingolipid metabolism KEAP1 2744.85442672705 2748.22561386288 2741.48323959122 0.997546644555799 -0.00354379260400237 0.948267199297722 1 35.9664 39.964 38.8501 38.7277 GeneID:9817,Genbank:NM_203500.1,HGNC:HGNC:23177,MIM:606016 kelch like ECH associated protein 1 GO:0001701,GO:0005654,GO:0005737,GO:0005783,GO:0005815,GO:0005829,GO:0005884,GO:0006351,GO:0008134,GO:0010499,GO:0016567,GO:0016579,GO:0030496,GO:0031463,GO:0032436,GO:0042803,GO:0042994,GO:0043234,GO:0043433,GO:0043687,GO:0045604,GO:0071353,GO:0097718 in utero embryonic development|nucleoplasm|cytoplasm|endoplasmic reticulum|microtubule organizing center|cytosol|actin filament|transcription, DNA-templated|transcription factor binding|proteasomal ubiquitin-independent protein catabolic process|protein ubiquitination|protein deubiquitination|midbody|Cul3-RING ubiquitin ligase complex|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein homodimerization activity|cytoplasmic sequestering of transcription factor|protein complex|negative regulation of DNA binding transcription factor activity|post-translational protein modification|regulation of epidermal cell differentiation|cellular response to interleukin-4|disordered domain specific binding hsa04120,hsa05200,hsa05225,hsa05418 Ubiquitin mediated proteolysis|Pathways in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis KEL 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0 0.0138028 GeneID:3792,Genbank:NM_000420.2,HGNC:HGNC:6308,MIM:613883 Kell blood group, metallo-endopeptidase KHDC1 215.980155394595 206.115095467637 225.845215321553 1.09572379843966 0.131884180744278 0.624791046432073 1 3.43592 4.17578 5.23991 4.14495 GeneID:80759,Genbank:NM_001251874.1,HGNC:HGNC:21366,MIM:611688 KH domain containing 1 GO:0003723,GO:0016021 RNA binding|integral component of membrane KHDC1L 1.4622745707901 1.47021420587209 1.45433493570811 0.989199349250911 -0.0156668042423989 1 1 0 0.221796 0.0776673 0.0724107 GeneID:100129128,Genbank:NM_001126063.2,HGNC:HGNC:37274 KH domain containing 1 like KHDC4 783.976114097735 800.809442060193 767.142786135277 0.957959217066292 -0.0619638570768754 0.709543308706248 1 9.39799 9.15473 8.55141 8.83607 GeneID:22889,Genbank:NM_014949.3,HGNC:HGNC:29145 KH domain containing 4, pre-mRNA splicing factor GO:0003723,GO:0005634,GO:0005737,GO:0006376 RNA binding|nucleus|cytoplasm|mRNA splice site selection KHDRBS1 4235.36107092802 4458.43029945712 4012.29184239892 0.899933737415941 -0.152109315912549 0.263472077496772 1 65.253 61.8203 60.1967 55.0226 GeneID:10657,Genbank:NM_006559.2,HGNC:HGNC:18116,MIM:602489 KH RNA binding domain containing, signal transduction associated 1 GO:0000086,GO:0003677,GO:0003723,GO:0005070,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006397,GO:0007050,GO:0007165,GO:0007166,GO:0007283,GO:0008143,GO:0008266,GO:0008283,GO:0016020,GO:0017124,GO:0019904,GO:0032403,GO:0042802,GO:0045892,GO:0045948,GO:0046831,GO:0046833,GO:0048024,GO:0051259,GO:0070618 G2/M transition of mitotic cell cycle|DNA binding|RNA binding|SH3/SH2 adaptor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|mRNA processing|cell cycle arrest|signal transduction|cell surface receptor signaling pathway|spermatogenesis|poly(A) binding|poly(U) RNA binding|cell proliferation|membrane|SH3 domain binding|protein domain specific binding|protein complex binding|identical protein binding|negative regulation of transcription, DNA-templated|positive regulation of translational initiation|regulation of RNA export from nucleus|positive regulation of RNA export from nucleus|regulation of mRNA splicing, via spliceosome|protein oligomerization|Grb2-Sos complex KHDRBS2 3.02473481826688 4.11267631439867 1.93679332213509 0.470932593298016 -1.08640751970762 0.611816776500908 1 0.00469558 0.00694947 0 0.00425416 GeneID:202559,Genbank:NM_152688.3,HGNC:HGNC:18114,MIM:610487 KH RNA binding domain containing, signal transduction associated 2 GO:0005654,GO:0006351,GO:0006355,GO:0006397,GO:0008143,GO:0008266,GO:0017124,GO:0042169,GO:0042802,GO:0046982,GO:0048024 nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA processing|poly(A) binding|poly(U) RNA binding|SH3 domain binding|SH2 domain binding|identical protein binding|protein heterodimerization activity|regulation of mRNA splicing, via spliceosome KHDRBS3 1963.43041544797 1745.38229268242 2181.47853821352 1.24985715012662 0.321763214422793 0.023608179107174 0.618322000227609 10.6988 11.5098 15.4778 12.5926 GeneID:10656,Genbank:XM_011516798.1,HGNC:HGNC:18117,MIM:610421 KH RNA binding domain containing, signal transduction associated 3 GO:0003723,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0006397,GO:0017124,GO:0019904,GO:0042802,GO:0048024,GO:0051259 RNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA processing|SH3 domain binding|protein domain specific binding|identical protein binding|regulation of mRNA splicing, via spliceosome|protein oligomerization KHK 201.357147326834 212.754564030977 189.95973062269 0.892858545657484 -0.163496465613992 0.465576313899157 1 1.78486 1.908 1.66021 1.64854 GeneID:3795,Genbank:NM_000221.2,HGNC:HGNC:6315,MIM:614058 ketohexokinase GO:0004454,GO:0005524,GO:0005737,GO:0005829,GO:0009744,GO:0009749,GO:0009750,GO:0010043,GO:0032868,GO:0061624,GO:0070062 ketohexokinase activity|ATP binding|cytoplasm|cytosol|response to sucrose|response to glucose|response to fructose|response to zinc ion|response to insulin|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate|extracellular exosome hsa00051 Fructose and mannose metabolism KHNYN 923.037260119114 802.655074809292 1043.41944542894 1.29995994316344 0.378467168876952 0.0147155657263353 0.505760731057911 3.80198 3.80608 5.34998 4.78169 GeneID:23351,Genbank:XM_011536590.2,HGNC:HGNC:20166 KH and NYN domain containing GO:0003723 RNA binding KHSRP 8348.93106481614 8354.07603872958 8343.78609090269 0.998768272184838 -0.001778102905006 0.981961513562175 1 75.8928 74.4389 77.1807 75.1917 GeneID:8570,Genbank:NM_003685.2,HGNC:HGNC:6316,MIM:603445 KH-type splicing regulatory protein GO:0000375,GO:0003677,GO:0003723,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0006397,GO:0006402,GO:0008380,GO:0010494,GO:0010586,GO:0016020,GO:0035925,GO:0043488,GO:0045019,GO:0051028,GO:0061014,GO:0061158,GO:0071345,GO:2000628 RNA splicing, via transesterification reactions|DNA binding|RNA binding|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA processing|mRNA catabolic process|RNA splicing|cytoplasmic stress granule|miRNA metabolic process|membrane|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|negative regulation of nitric oxide biosynthetic process|mRNA transport|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|cellular response to cytokine stimulus|regulation of miRNA metabolic process KIAA0040 46.7887024163619 52.3787880787901 41.1986167539338 0.786551546247334 -0.346386779877553 0.446403384035536 1 0.405107 0.25974 0.329215 0.211245 GeneID:9674,Genbank:XM_024451079.1,HGNC:HGNC:28950,MIM:616696 KIAA0040 KIAA0100 14286.1833824591 13563.6805918303 15008.686173088 1.10653491664556 0.14604897601612 0.263108596762939 1 56.2952 57.8926 67.6318 62.238 GeneID:9703,Genbank:NM_001321560.1,HGNC:HGNC:28960,MIM:610664 KIAA0100 GO:0005576 extracellular region KIAA0232 808.710818000512 841.474542766692 775.947093234332 0.92212782894547 -0.116961338372946 0.476223847246711 1 3.24981 3.0279 3.31308 2.63939 GeneID:9778,Genbank:NM_014743.2,HGNC:HGNC:28992 KIAA0232 GO:0005524 ATP binding KIAA0319 81.8733123541769 68.2629866952734 95.4836380130803 1.39876150510847 0.484149997721546 0.145301130801137 1 0.209003 0.25335 0.408453 0.291619 GeneID:9856,Genbank:XM_017011546.2,HGNC:HGNC:21580,MIM:609269 KIAA0319 KIAA0319L 2161.11204105968 2038.54576725312 2283.67831486623 1.12024873395088 0.163819096029516 0.25084765028862 1 6.38896 7.25866 8.35401 7.0768 GeneID:79932,Genbank:XM_017002372.2,HGNC:HGNC:30071,MIM:613535 KIAA0319 like GO:0000139,GO:0005886,GO:0016021,GO:0031410,GO:0070062 Golgi membrane|plasma membrane|integral component of membrane|cytoplasmic vesicle|extracellular exosome KIAA0355 562.569639989079 559.093656039902 566.045623938257 1.01243435303415 0.0178283656540561 0.916016572514838 1 3.66266 3.39711 3.67666 3.50925 GeneID:9710,Genbank:NM_014686.3,HGNC:HGNC:29016 KIAA0355 KIAA0391 766.158593007646 779.2178914096 753.099294605691 0.966481009879456 -0.049186709291917 0.771230127399666 1 10.0372 10.0189 9.64321 9.62664 GeneID:9692,Genbank:XM_011537410.2,HGNC:HGNC:19958,MIM:609947 KIAA0391 GO:0001682,GO:0004526,GO:0005634,GO:0005739,GO:0005759,GO:0030678,GO:0046872,GO:0090646,GO:0097745 tRNA 5'-leader removal|ribonuclease P activity|nucleus|mitochondrion|mitochondrial matrix|mitochondrial ribonuclease P complex|metal ion binding|mitochondrial tRNA processing|mitochondrial tRNA 5'-end processing KIAA0513 418.407887704663 365.240154276306 471.575621133021 1.29113848959847 0.368643754743629 0.040927842186179 0.759435523043776 1.39632 1.17475 1.86099 1.48555 GeneID:9764,Genbank:XM_005256265.3,HGNC:HGNC:29058,MIM:611675 KIAA0513 GO:0005737 cytoplasm KIAA0556 511.569451082526 511.385259262369 511.753642902683 1.00072036421395 0.00103889173379619 0.997300687087049 1 2.00474 2.10128 2.07138 2.05352 GeneID:23247,Genbank:XM_005255201.3,HGNC:HGNC:29068,MIM:616650 KIAA0556 GO:0005615,GO:0005737,GO:0005856,GO:0042995 extracellular space|cytoplasm|cytoskeleton|cell projection KIAA0586 177.637825470363 187.078746030454 168.196904910272 0.899070089356339 -0.153494505704631 0.590689387141238 1 0.691535 0.671047 0.804041 0.478889 GeneID:9786,Genbank:NM_001244189.1,HGNC:HGNC:19960,MIM:610178 KIAA0586 GO:0001917,GO:0005813,GO:0005814,GO:0007224,GO:0036064,GO:0060271,GO:0070201 photoreceptor inner segment|centrosome|centriole|smoothened signaling pathway|ciliary basal body|cilium assembly|regulation of establishment of protein localization KIAA0753 388.885448878863 415.246037585318 362.524860172407 0.8730362901968 -0.195886470129112 0.295214056764302 1 1.62087 1.62482 1.58387 1.32636 GeneID:9851,Genbank:XM_011524096.2,HGNC:HGNC:29110,MIM:617112 KIAA0753 GO:0005813,GO:0005814,GO:0005829,GO:0007099,GO:0034451,GO:0071539 centrosome|centriole|cytosol|centriole replication|centriolar satellite|protein localization to centrosome KIAA0754 1093.76473675595 1062.4358591171 1125.09361439479 1.05897556519766 0.0826693009687144 0.831813416244222 1 5.56866 5.64085 7.87657 4.36004 GeneID:643314,Genbank:NM_015038.1,HGNC:HGNC:29111 KIAA0754 KIAA0825 10.2469828037621 9.34957425676688 11.1443913507573 1.19196778855373 0.253345249288585 0.812633834333738 1 0.0162277 0.00710588 0.0122759 0.017946 GeneID:285600,Genbank:NM_001145678.1,HGNC:HGNC:28532,MIM:617266 KIAA0825 KIAA0895 167.026184408135 191.565823887225 142.486544929046 0.743799400319589 -0.427014510094634 0.0865431065962867 0.964561165794104 1.72136 1.28414 1.28925 1.04277 GeneID:23366,Genbank:NM_001100425.1,HGNC:HGNC:22206 KIAA0895 KIAA0895L 333.624060138512 337.230666126437 330.017454150586 0.978610450648796 -0.0311934053938598 0.856534545400397 1 3.29389 3.97674 3.52532 3.51706 GeneID:653319,Genbank:NM_001040715.1,HGNC:HGNC:34408 KIAA0895 like KIAA0930 1718.8722567971 1650.90539030998 1786.83912328422 1.08233889947425 0.114152303265261 0.431090438382466 1 9.08355 9.196 10.403 9.74238 GeneID:23313,Genbank:NM_001009880.1,HGNC:HGNC:1314 KIAA0930 KIAA1024 145.828212792441 140.907190042839 150.749235542042 1.06984771675747 0.0974054565197748 0.766674073720394 1 0.535945 0.514113 0.696506 0.417321 GeneID:23251,Genbank:XM_017022027.1,HGNC:HGNC:29172 KIAA1024 GO:0016021 integral component of membrane KIAA1107 5.96329089844916 5.14084539299833 6.7857364039 1.31996508067369 0.40049976397368 0.801682188277187 1 0.0177216 0.0215578 0.0299873 0.023886 GeneID:23285,Genbank:NM_015237.3,HGNC:HGNC:29192 KIAA1107 KIAA1109 169.012738222477 154.311605684212 183.713870760741 1.19053826150121 0.251613986665396 0.524624285529413 1 0.272455 0.226913 0.382935 0.215546 GeneID:84162,Genbank:XM_011532327.1,HGNC:HGNC:26953,MIM:611565 KIAA1109 GO:0001558,GO:0005634,GO:0016020,GO:0016021,GO:0030856 regulation of cell growth|nucleus|membrane|integral component of membrane|regulation of epithelial cell differentiation KIAA1143 509.07142712435 531.55360498092 486.589249267781 0.915409555514627 -0.127510743279119 0.481768749083643 1 3.79559 3.67931 3.67669 3.16701 GeneID:57456,Genbank:NM_020696.3,HGNC:HGNC:29198 KIAA1143 KIAA1147 1721.21833183658 1637.94977744842 1804.48688622473 1.10167412399893 0.139697536778702 0.482203456963128 1 9.43917 8.78822 11.6895 8.51788 GeneID:57189,Genbank:XM_024446843.1,HGNC:HGNC:29472 KIAA1147 GO:0005737,GO:0051179 cytoplasm|localization KIAA1191 3941.07112672414 3958.15807130977 3923.9841821385 0.991366214144156 -0.0125100024269605 0.91812506117578 1 46.511 48.8691 48.5221 47.5823 GeneID:57179,Genbank:NM_001287335.1,HGNC:HGNC:29209 KIAA1191 GO:0005737,GO:0016491 cytoplasm|oxidoreductase activity KIAA1211 841.465259425147 701.471060288613 981.45945856168 1.39914461782339 0.484545089474508 0.00198697294784923 0.159116793663767 2.6647 2.52385 4.24557 3.27542 GeneID:57482,Genbank:XM_024454158.1,HGNC:HGNC:29219 KIAA1211 KIAA1211L 7.59105710913524 5.48683797090087 9.69527624736962 1.76700611514099 0.821307032684276 0.492899171709956 1 0.00744385 0.0208461 0.0424622 0.0231313 GeneID:343990,Genbank:NM_207362.2,HGNC:HGNC:33454 KIAA1211 like KIAA1217 863.364451126484 738.456738153732 988.272164099236 1.33829392168604 0.420395001473244 0.0340058934175602 0.729079834868512 1.79414 1.74893 2.82681 2.12382 GeneID:56243,Genbank:XM_024448086.1,HGNC:HGNC:25428,MIM:617367 KIAA1217 GO:0005737,GO:0048706 cytoplasm|embryonic skeletal system development KIAA1257 24.5539391674194 26.3383771910039 22.7695011438349 0.864499015209337 -0.210063774459268 0.772763170030545 1 0.048551 0.0289466 0.0114902 0.0407577 GeneID:57501,Genbank:NM_001348521.1,HGNC:HGNC:29231 KIAA1257 KIAA1324 70.4620261145045 66.3027010874439 74.621351141565 1.12546472342281 0.170520837653401 0.653854437136046 1 0.219573 0.291202 0.20766 0.308889 GeneID:57535,Genbank:NM_020775.4,HGNC:HGNC:29618,MIM:611298 KIAA1324 GO:0000045,GO:0003723,GO:0005765,GO:0005794,GO:0005886,GO:0005887,GO:0009267,GO:0031902,GO:0044090,GO:0070062,GO:2000786 autophagosome assembly|RNA binding|lysosomal membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|cellular response to starvation|late endosome membrane|positive regulation of vacuole organization|extracellular exosome|positive regulation of autophagosome assembly KIAA1324L 71.2360217453122 63.948396627027 78.5236468635973 1.22792205911868 0.296218990275246 0.404274808971794 1 0.245843 0.271419 0.396464 0.211762 GeneID:222223,Genbank:XM_011515918.2,HGNC:HGNC:21945,MIM:614048 KIAA1324 like GO:0016021 integral component of membrane KIAA1328 42.9384609727266 42.2607934270642 43.616128518389 1.03207074409675 0.0455418648110745 0.966292591985319 1 0.104812 0.106702 0.107431 0.0970153 GeneID:57536,Genbank:XM_005258315.5,HGNC:HGNC:29248,MIM:616480 KIAA1328 KIAA1468 286.244810667438 286.061326569024 286.428294765853 1.00128283050781 0.00184954713765884 0.974897365279495 1 0.973669 0.933166 0.997537 0.909532 GeneID:57614,Genbank:XM_011526112.2,HGNC:HGNC:29289 KIAA1468 KIAA1522 2089.59780107496 1745.32445775262 2433.8711443973 1.39450927510137 0.479757529990642 0.000666607608839559 0.0757017541055678 11.3492 11.6376 17.5606 15.5989 GeneID:57648,Genbank:XM_017001917.1,HGNC:HGNC:29301 KIAA1522 GO:0030154 cell differentiation KIAA1549 857.31461282318 866.449583957156 848.179641689204 0.978914015764758 -0.0307459505615844 0.843303959125441 1 2.56642 2.69063 2.94404 2.26141 GeneID:57670,Genbank:XM_011516442.2,HGNC:HGNC:22219,MIM:613344 KIAA1549 GO:0005886,GO:0016021 plasma membrane|integral component of membrane KIAA1549L 66.3710051612868 65.3705845582142 67.3714257643594 1.03060766887228 0.0434952329061646 0.940459574988724 1 0.164959 0.171409 0.223983 0.159492 GeneID:25758,Genbank:XM_005252847.3,HGNC:HGNC:24836,MIM:612297 KIAA1549 like GO:0016021 integral component of membrane KIAA1551 42.1420840534914 47.4398564396395 36.8443116673434 0.776653102106718 -0.364657742872841 0.499758928771384 1 0.242334 0.190942 0.229082 0.104323 GeneID:55196,Genbank:NM_018169.3,HGNC:HGNC:25559 KIAA1551 KIAA1586 129.608178477081 137.08267137655 122.133685577613 0.890949121075453 -0.166585047952707 0.559346189815322 1 1.89049 1.51125 1.636 1.37218 GeneID:57691,Genbank:NM_020931.3,HGNC:HGNC:21360 KIAA1586 GO:0016874,GO:0016925,GO:0061665 ligase activity|protein sumoylation|SUMO ligase activity KIAA1614 6.44128953800775 3.67063118712625 9.21194788888925 2.50963592343401 1.32747808546931 0.271252146531788 1 0.0533385 0.00914046 0.117622 0.0459142 GeneID:57710,Genbank:NM_020950.1,HGNC:HGNC:29327 KIAA1614 KIAA1671 515.099098182717 479.636479339618 550.561717025817 1.14787290112681 0.198962907636189 0.251748661611621 1 2.53384 2.41975 3.25151 2.70848 GeneID:85379,Genbank:XM_005261794.4,HGNC:HGNC:29345 KIAA1671 KIAA1755 2.43948083899303 2.94042841174417 1.93853326624189 0.659268989001506 -0.60106087408571 0.840582952682011 1 0 0.0111598 0.00389455 0.00364795 GeneID:85449,Genbank:NM_001348708.1,HGNC:HGNC:29372 KIAA1755 KIAA1841 136.432245358747 124.562345989722 148.302144727771 1.19058567458265 0.251671440724334 0.34422039828714 1 0.75211 0.761055 0.928726 0.792977 GeneID:84542,Genbank:NM_001330433.1,HGNC:HGNC:29387 KIAA1841 KIAA1958 227.452880481506 210.130702231811 244.775058731201 1.16487051216899 0.22016959279002 0.420271789586099 1 0.448461 0.402457 0.591027 0.397372 GeneID:158405,Genbank:NM_001287036.1,HGNC:HGNC:23427,MIM:617390 KIAA1958 GO:0000981,GO:0003677,GO:0005654,GO:0005737 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm KIAA2013 2366.56424467279 2249.4371152265 2483.69137411908 1.10413905652526 0.142921878208426 0.319968016742446 1 30.5613 34.1682 37.2718 36.3734 GeneID:90231,Genbank:NM_138346.2,HGNC:HGNC:28513 KIAA2013 GO:0016020,GO:0016021 membrane|integral component of membrane KIAA2026 120.448930927646 106.62180921604 134.276052639253 1.25936760618252 0.332699463522388 0.501631971684185 1 0.261765 0.182787 0.349575 0.170172 GeneID:158358,Genbank:XM_011517760.3,HGNC:HGNC:23378 KIAA2026 KIDINS220 734.663565823243 687.008032602462 782.319099044023 1.13873355465803 0.187430219090227 0.54390671924077 1 2.05132 1.64342 2.60189 1.71066 GeneID:57498,Genbank:NM_001348742.1,HGNC:HGNC:29508,MIM:615759 kinase D interacting substrate 220 GO:0000186,GO:0001701,GO:0005770,GO:0005829,GO:0010976,GO:0016020,GO:0016021,GO:0019887,GO:0030165,GO:0038180,GO:0043234,GO:0045859,GO:0048813,GO:1990090 activation of MAPKK activity|in utero embryonic development|late endosome|cytosol|positive regulation of neuron projection development|membrane|integral component of membrane|protein kinase regulator activity|PDZ domain binding|nerve growth factor signaling pathway|protein complex|regulation of protein kinase activity|dendrite morphogenesis|cellular response to nerve growth factor stimulus hsa04722 Neurotrophin signaling pathway KIF11 937.830795804435 1012.36131522234 863.300276386532 0.852759052924629 -0.229789929258426 0.493180938922054 1 7.27305 6.32625 7.39306 4.37039 GeneID:3832,Genbank:NM_004523.3,HGNC:HGNC:6388,MIM:148760 kinesin family member 11 GO:0000278,GO:0000922,GO:0003777,GO:0005524,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0007051,GO:0007052,GO:0007059,GO:0007100,GO:0008017,GO:0008574,GO:0016020,GO:0019886,GO:0019901,GO:0032403,GO:0046602,GO:0051301,GO:0072686,GO:0090307 mitotic cell cycle|spindle pole|microtubule motor activity|ATP binding|spindle|cytosol|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|spindle organization|mitotic spindle organization|chromosome segregation|mitotic centrosome separation|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|protein complex binding|regulation of mitotic centrosome separation|cell division|mitotic spindle|mitotic spindle assembly KIF12 0.972203168832738 0.490071401957362 1.45433493570811 2.96759804775273 1.56929569647876 0.837430708298891 1 0 0.0114329 0.0121898 0 GeneID:113220,Genbank:XM_005251683.5,HGNC:HGNC:21495,MIM:611278 kinesin family member 12 GO:0003777,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887,GO:0070062 microtubule motor activity|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity|extracellular exosome KIF13A 1994.71472480476 2036.6108396072 1952.81861000232 0.958857024633609 -0.0606123841588328 0.773314707575082 1 6.77933 6.33102 7.54169 5.27133 GeneID:63971,Genbank:NM_001105568.2,HGNC:HGNC:14566,MIM:605433 kinesin family member 13A GO:0000910,GO:0003777,GO:0005524,GO:0005813,GO:0005871,GO:0005874,GO:0006886,GO:0007018,GO:0008017,GO:0008333,GO:0010008,GO:0016887,GO:0030496,GO:0030705,GO:0032438,GO:0032588,GO:0035459,GO:0043001,GO:0072383 cytokinesis|microtubule motor activity|ATP binding|centrosome|kinesin complex|microtubule|intracellular protein transport|microtubule-based movement|microtubule binding|endosome to lysosome transport|endosome membrane|ATPase activity|midbody|cytoskeleton-dependent intracellular transport|melanosome organization|trans-Golgi network membrane|cargo loading into vesicle|Golgi to plasma membrane protein transport|plus-end-directed vesicle transport along microtubule KIF13B 1601.11859273476 1535.48968782232 1666.7474976472 1.08548270357389 0.118336737775277 0.406664652607293 1 5.92634 5.62562 6.93623 5.71871 GeneID:23303,Genbank:XM_011544459.3,HGNC:HGNC:14405,MIM:607350 kinesin family member 13B GO:0003777,GO:0005524,GO:0005737,GO:0005829,GO:0005871,GO:0005874,GO:0005902,GO:0006605,GO:0007018,GO:0007165,GO:0008017,GO:0016887,GO:0019901,GO:0030424,GO:0030705,GO:0033270,GO:0042110,GO:0050770,GO:0071889 microtubule motor activity|ATP binding|cytoplasm|cytosol|kinesin complex|microtubule|microvillus|protein targeting|microtubule-based movement|signal transduction|microtubule binding|ATPase activity|protein kinase binding|axon|cytoskeleton-dependent intracellular transport|paranode region of axon|T cell activation|regulation of axonogenesis|14-3-3 protein binding KIF14 142.838251112586 145.096301596392 140.580200628779 0.968875147623164 -0.0456173276062208 0.960569622415185 1 0.705911 0.513063 0.83441 0.389754 GeneID:9928,Genbank:NM_014875.2,HGNC:HGNC:19181,MIM:611279 kinesin family member 14 KIF15 163.794892076918 161.354901755247 166.234882398589 1.0302437706587 0.0429857404279455 0.842518480405675 1 0.811166 0.605118 0.709444 0.643785 GeneID:56992,Genbank:NM_020242.2,HGNC:HGNC:17273,MIM:617569 kinesin family member 15 GO:0000278,GO:0003677,GO:0003774,GO:0003777,GO:0005524,GO:0005813,GO:0005819,GO:0005829,GO:0005873,GO:0005874,GO:0006890,GO:0007018,GO:0008017,GO:0008283,GO:0016020,GO:0016887,GO:0019886 mitotic cell cycle|DNA binding|motor activity|microtubule motor activity|ATP binding|centrosome|spindle|cytosol|plus-end kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|microtubule binding|cell proliferation|membrane|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II KIF16B 69.1203494681434 64.0826667959739 74.1580321403128 1.15722450153981 0.210668774418666 0.537838586882498 1 0.278457 0.218287 0.345957 0.231077 GeneID:55614,Genbank:XM_005260755.3,HGNC:HGNC:15869 kinesin family member 16B GO:0001704,GO:0001919,GO:0005524,GO:0005547,GO:0005768,GO:0005769,GO:0005829,GO:0005871,GO:0005874,GO:0006895,GO:0007018,GO:0007173,GO:0007492,GO:0008017,GO:0008543,GO:0008574,GO:0017137,GO:0031901,GO:0032266,GO:0032801,GO:0043325,GO:0045022,GO:0045335,GO:0071346,GO:0080025 formation of primary germ layer|regulation of receptor recycling|ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|endosome|early endosome|cytosol|kinesin complex|microtubule|Golgi to endosome transport|microtubule-based movement|epidermal growth factor receptor signaling pathway|endoderm development|microtubule binding|fibroblast growth factor receptor signaling pathway|ATP-dependent microtubule motor activity, plus-end-directed|Rab GTPase binding|early endosome membrane|phosphatidylinositol-3-phosphate binding|receptor catabolic process|phosphatidylinositol-3,4-bisphosphate binding|early endosome to late endosome transport|phagocytic vesicle|cellular response to interferon-gamma|phosphatidylinositol-3,5-bisphosphate binding KIF17 42.9760331564496 35.5536812788238 50.3983850340754 1.41752930276993 0.503378558464795 0.265979387977138 1 0.225389 0.30998 0.374614 0.408066 GeneID:57576,Genbank:NM_001122819.2,HGNC:HGNC:19167,MIM:605037 kinesin family member 17 GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0005929,GO:0005930,GO:0007018,GO:0008017,GO:0008574,GO:0016192,GO:0022008,GO:0030030,GO:0030992,GO:0032391,GO:0032839,GO:0035735,GO:0036064,GO:0098971,GO:1990075 ATP binding|cytosol|kinesin complex|microtubule|cilium|axoneme|microtubule-based movement|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|vesicle-mediated transport|neurogenesis|cell projection organization|intraciliary transport particle B|photoreceptor connecting cilium|dendrite cytoplasm|intraciliary transport involved in cilium assembly|ciliary basal body|anterograde dendritic transport of neurotransmitter receptor complex|periciliary membrane compartment KIF18A 132.246375070836 136.5347650448 127.957985096872 0.937182446206184 -0.093598162675705 0.81042746123511 1 1.01515 0.758727 1.07061 0.731019 GeneID:81930,Genbank:NM_031217.3,HGNC:HGNC:29441,MIM:611271 kinesin family member 18A GO:0000776,GO:0001726,GO:0003779,GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005828,GO:0005829,GO:0005871,GO:0005901,GO:0006890,GO:0007018,GO:0007019,GO:0007062,GO:0007080,GO:0007140,GO:0008017,GO:0008574,GO:0015031,GO:0015630,GO:0019886,GO:0051010,GO:0070463,GO:0070507,GO:0071392,GO:0072520,GO:1990023 kinetochore|ruffle|actin binding|ATP binding|nucleus|cytoplasm|microtubule organizing center|kinetochore microtubule|cytosol|kinesin complex|caveola|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|microtubule depolymerization|sister chromatid cohesion|mitotic metaphase plate congression|male meiotic nuclear division|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|protein transport|microtubule cytoskeleton|antigen processing and presentation of exogenous peptide antigen via MHC class II|microtubule plus-end binding|tubulin-dependent ATPase activity|regulation of microtubule cytoskeleton organization|cellular response to estradiol stimulus|seminiferous tubule development|mitotic spindle midzone KIF18B 1703.15669555252 1787.20002398135 1619.11336712368 0.905949723253008 -0.142497106454924 0.315972145153195 1 12.1539 11.4998 11.0762 10.9696 GeneID:146909,Genbank:XM_011524386.2,HGNC:HGNC:27102,MIM:614570 kinesin family member 18B GO:0000070,GO:0000235,GO:0000278,GO:0003774,GO:0003777,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005871,GO:0007018,GO:0007019,GO:0008017,GO:0016604,GO:0016887,GO:0019894,GO:0035371,GO:0051301,GO:0051302,GO:1990752 mitotic sister chromatid segregation|astral microtubule|mitotic cell cycle|motor activity|microtubule motor activity|ATP binding|nucleus|cytoplasm|cytosol|kinesin complex|microtubule-based movement|microtubule depolymerization|microtubule binding|nuclear body|ATPase activity|kinesin binding|microtubule plus-end|cell division|regulation of cell division|microtubule end KIF19 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:124602,Genbank:XM_017024150.1,HGNC:HGNC:26735 kinesin family member 19 GO:0003777,GO:0005524,GO:0005871,GO:0005874,GO:0005929,GO:0005930,GO:0007018,GO:0008017,GO:0008574,GO:0016887,GO:0060404,GO:0070462 microtubule motor activity|ATP binding|kinesin complex|microtubule|cilium|axoneme|microtubule-based movement|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|ATPase activity|axonemal microtubule depolymerization|plus-end specific microtubule depolymerization KIF1A 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0 0.0038847 0 0 GeneID:547,Genbank:NM_004321.7,HGNC:HGNC:888,MIM:601255 kinesin family member 1A GO:0003774,GO:0003777,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0008017,GO:0008021,GO:0008089,GO:0016887,GO:0022027,GO:0030425,GO:0042802,GO:0042803,GO:0043025,GO:0098794,GO:0098840,GO:1904115 motor activity|microtubule motor activity|ATP binding|cytosol|kinesin complex|microtubule|microtubule binding|synaptic vesicle|anterograde axonal transport|ATPase activity|interkinetic nuclear migration|dendrite|identical protein binding|protein homodimerization activity|neuronal cell body|postsynapse|protein transport along microtubule|axon cytoplasm KIF1B 2124.0365138926 2020.46689230708 2227.60613547813 1.10252048373558 0.140805459872795 0.464122569137199 1 4.94381 4.3932 5.92522 4.39058 GeneID:23095,Genbank:NM_015074.3,HGNC:HGNC:16636,MIM:605995 kinesin family member 1B GO:0003723,GO:0003774,GO:0003777,GO:0005524,GO:0005783,GO:0005794,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0008017,GO:0016887,GO:0030705 RNA binding|motor activity|microtubule motor activity|ATP binding|endoplasmic reticulum|Golgi apparatus|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|microtubule binding|ATPase activity|cytoskeleton-dependent intracellular transport KIF1BP 1601.91414770993 1590.8755308969 1612.95276452296 1.01387741102135 0.0198832251191504 0.875957665155228 1 17.964 17.3109 19.6177 16.1381 GeneID:26128,Genbank:NM_015634.3,HGNC:HGNC:23419,MIM:609367 KIF1 binding protein GO:0005739,GO:0005856,GO:0006839,GO:0007399,GO:0019894,GO:0030154 mitochondrion|cytoskeleton|mitochondrial transport|nervous system development|kinesin binding|cell differentiation KIF1C 7836.04753780249 7220.70733884506 8451.38773675992 1.17043765107252 0.227048084484734 0.0858241161324911 0.964561165794104 33.5575 34.9779 41.5177 40.009 GeneID:10749,Genbank:NM_006612.5,HGNC:HGNC:6317,MIM:603060 kinesin family member 1C GO:0003723,GO:0003774,GO:0003777,GO:0005524,GO:0005783,GO:0005794,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0008017,GO:0016887,GO:0030705 RNA binding|motor activity|microtubule motor activity|ATP binding|endoplasmic reticulum|Golgi apparatus|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|microtubule binding|ATPase activity|cytoskeleton-dependent intracellular transport KIF20A 5155.28731639896 5193.93004289145 5116.64458990646 0.985120043522579 -0.0216285574834911 0.872532386224741 1 45.6032 45.7794 45.3522 44.8907 GeneID:10112,Genbank:NM_005733.2,HGNC:HGNC:9787,MIM:605664 kinesin family member 20A GO:0000281,GO:0000910,GO:0000920,GO:0001578,GO:0003777,GO:0005215,GO:0005524,GO:0005654,GO:0005794,GO:0005819,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0015031,GO:0016192,GO:0016887,GO:0019901,GO:0030496,GO:0032154,GO:0045171 mitotic cytokinesis|cytokinesis|cell separation after cytokinesis|microtubule bundle formation|microtubule motor activity|transporter activity|ATP binding|nucleoplasm|Golgi apparatus|spindle|kinesin complex|microtubule|microtubule-based movement|microtubule binding|protein transport|vesicle-mediated transport|ATPase activity|protein kinase binding|midbody|cleavage furrow|intercellular bridge KIF20B 136.138522340731 128.79948381796 143.477560863501 1.11396068222049 0.155698312959317 0.681613874175316 1 0.64668 0.449908 0.751863 0.465902 GeneID:9585,Genbank:NM_001284259.1,HGNC:HGNC:7212,MIM:605498 kinesin family member 20B GO:0001843,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005813,GO:0005871,GO:0005874,GO:0007018,GO:0007050,GO:0007088,GO:0008017,GO:0008284,GO:0008574,GO:0016887,GO:0030424,GO:0030426,GO:0030496,GO:0032467,GO:0035372,GO:0042803,GO:0048471,GO:0048812,GO:0050699,GO:0051233,GO:0051301,GO:0070938,GO:0090316,GO:0097431,GO:1903438,GO:1990023,GO:2000114,GO:2001224 neural tube closure|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|centrosome|kinesin complex|microtubule|microtubule-based movement|cell cycle arrest|regulation of mitotic nuclear division|microtubule binding|positive regulation of cell proliferation|ATP-dependent microtubule motor activity, plus-end-directed|ATPase activity|axon|growth cone|midbody|positive regulation of cytokinesis|protein localization to microtubule|protein homodimerization activity|perinuclear region of cytoplasm|neuron projection morphogenesis|WW domain binding|spindle midzone|cell division|contractile ring|positive regulation of intracellular protein transport|mitotic spindle pole|positive regulation of mitotic cytokinetic process|mitotic spindle midzone|regulation of establishment of cell polarity|positive regulation of neuron migration KIF21A 161.382696499986 185.108651767517 137.656741232455 0.74365374021168 -0.427297064361764 0.136753857413993 1 0.700824 0.699004 0.676863 0.443268 GeneID:55605,Genbank:NM_001173465.1,HGNC:HGNC:19349,MIM:608283 kinesin family member 21A GO:0003777,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0005886,GO:0007018,GO:0008017,GO:0016887 microtubule motor activity|ATP binding|cytosol|kinesin complex|microtubule|plasma membrane|microtubule-based movement|microtubule binding|ATPase activity KIF21B 16.1095575792176 18.6511222388488 13.5679929195864 0.727462548678457 -0.459055117968369 0.555332137203631 1 0.0793611 0.0292808 0.0427429 0.0545734 GeneID:23046,Genbank:NM_001252103.1,HGNC:HGNC:29442,MIM:608322 kinesin family member 21B GO:0003777,GO:0005524,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887,GO:0030424,GO:0030425,GO:0030426,GO:0031410 microtubule motor activity|ATP binding|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity|axon|dendrite|growth cone|cytoplasmic vesicle KIF22 2429.03139465048 2452.04324163957 2406.01954766139 0.981230472123566 -0.0273360573851134 0.828125434523132 1 28.5916 30.046 28.1427 30.8864 GeneID:3835,Genbank:NM_001256269.1,HGNC:HGNC:6391,MIM:603213 kinesin family member 22 GO:0000278,GO:0000776,GO:0000785,GO:0003677,GO:0003777,GO:0005524,GO:0005634,GO:0005829,GO:0005871,GO:0005874,GO:0006281,GO:0006890,GO:0007018,GO:0007062,GO:0007080,GO:0008017,GO:0016607,GO:0016887,GO:0019886,GO:0051310,GO:0072686 mitotic cell cycle|kinetochore|chromatin|DNA binding|microtubule motor activity|ATP binding|nucleus|cytosol|kinesin complex|microtubule|DNA repair|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|sister chromatid cohesion|mitotic metaphase plate congression|microtubule binding|nuclear speck|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|metaphase plate congression|mitotic spindle hsa04914 Progesterone-mediated oocyte maturation KIF23 1839.15949405046 2031.38273331908 1646.93625478183 0.810746408231447 -0.302677367619365 0.0804007194487472 0.951623427935096 13.6863 12.5476 12.2674 9.66434 GeneID:9493,Genbank:NM_138555.3,HGNC:HGNC:6392,MIM:605064 kinesin family member 23 GO:0000022,GO:0000281,GO:0000915,GO:0003777,GO:0005524,GO:0005634,GO:0005654,GO:0005813,GO:0005819,GO:0005829,GO:0005871,GO:0005874,GO:0005925,GO:0006890,GO:0007018,GO:0008017,GO:0016887,GO:0019886,GO:0030496,GO:0032467,GO:0045171,GO:0051256,GO:0072383,GO:0072686,GO:0090543,GO:0097149 mitotic spindle elongation|mitotic cytokinesis|actomyosin contractile ring assembly|microtubule motor activity|ATP binding|nucleus|nucleoplasm|centrosome|spindle|cytosol|kinesin complex|microtubule|focal adhesion|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|microtubule binding|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|positive regulation of cytokinesis|intercellular bridge|mitotic spindle midzone assembly|plus-end-directed vesicle transport along microtubule|mitotic spindle|Flemming body|centralspindlin complex hsa05206 MicroRNAs in cancer KIF24 690.22896011621 669.935019775673 710.522900456748 1.06058480223152 0.0848599804795498 0.620090072240517 1 2.03249 2.28692 2.64396 2.12238 GeneID:347240,Genbank:XM_011517863.3,HGNC:HGNC:19916,MIM:613747 kinesin family member 24 GO:0003777,GO:0005524,GO:0005814,GO:0005829,GO:0005871,GO:0005874,GO:0007018,GO:0007019,GO:0008017,GO:0016887,GO:0042802,GO:0043234,GO:0060271,GO:0097711 microtubule motor activity|ATP binding|centriole|cytosol|kinesin complex|microtubule|microtubule-based movement|microtubule depolymerization|microtubule binding|ATPase activity|identical protein binding|protein complex|cilium assembly|ciliary basal body-plasma membrane docking KIF25 1.83031249419293 2.69048838321152 0.97013660517434 0.360580112974258 -1.47160826468559 0.720020310446899 1 0.0239905 0 0.0224322 0 GeneID:3834,Genbank:XM_011535802.3,HGNC:HGNC:6390,MIM:603815 kinesin family member 25 GO:0000070,GO:0003777,GO:0005524,GO:0005737,GO:0005813,GO:0005871,GO:0005874,GO:0006996,GO:0007018,GO:0008017,GO:0008569,GO:0010507,GO:0016887,GO:0046603,GO:0051289,GO:0051294,GO:0051647 mitotic sister chromatid segregation|microtubule motor activity|ATP binding|cytoplasm|centrosome|kinesin complex|microtubule|organelle organization|microtubule-based movement|microtubule binding|ATP-dependent microtubule motor activity, minus-end-directed|negative regulation of autophagy|ATPase activity|negative regulation of mitotic centrosome separation|protein homotetramerization|establishment of spindle orientation|nucleus localization KIF26B 461.231042294302 453.788173550571 468.673911038032 1.03280327332242 0.0465654781808016 0.802129732213654 1 1.38565 1.39214 1.6415 1.26308 GeneID:55083,Genbank:NM_018012.4,HGNC:HGNC:25484,MIM:614026 kinesin family member 26B GO:0003777,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0008017,GO:0022409,GO:0030010,GO:0072092 microtubule motor activity|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule binding|positive regulation of cell-cell adhesion|establishment of cell polarity|ureteric bud invasion KIF27 27.9026959689247 26.242324641634 29.5630672962155 1.1265414821259 0.171900438256405 0.771241938653303 1 0.0579259 0.0564453 0.0400499 0.0335025 GeneID:55582,Genbank:XM_017014916.1,HGNC:HGNC:18632,MIM:611253 kinesin family member 27 GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0005929,GO:0007018,GO:0008017,GO:0008574,GO:0060271,GO:0070062 ATP binding|cytoplasm|kinesin complex|microtubule|cilium|microtubule-based movement|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|cilium assembly|extracellular exosome KIF2A 611.49537944252 649.119664173437 573.871094711603 0.884075966859435 -0.177757752077761 0.51730251820001 1 5.09464 4.35865 5.07494 3.63553 GeneID:3796,Genbank:NM_001243952.1,HGNC:HGNC:6318,MIM:602591 kinesin family member 2A GO:0000922,GO:0003777,GO:0005524,GO:0005737,GO:0005815,GO:0005874,GO:0007018,GO:0007052,GO:0007399,GO:0008017,GO:0030154,GO:0051301,GO:0090307 spindle pole|microtubule motor activity|ATP binding|cytoplasm|microtubule organizing center|microtubule|microtubule-based movement|mitotic spindle organization|nervous system development|microtubule binding|cell differentiation|cell division|mitotic spindle assembly KIF2C 5057.55185313103 5165.26780420621 4949.83590205584 0.958292210526831 -0.061462453125301 0.638978227032207 1 42.9546 44.4424 42.1152 43.713 GeneID:11004,Genbank:XM_011540540.2,HGNC:HGNC:6393,MIM:604538 kinesin family member 2C GO:0000278,GO:0000775,GO:0000776,GO:0000777,GO:0003777,GO:0005524,GO:0005634,GO:0005829,GO:0005871,GO:0006890,GO:0007018,GO:0007019,GO:0007062,GO:0007080,GO:0008283,GO:0015630,GO:0016020,GO:0016887,GO:0019237,GO:0019886,GO:0030951,GO:0035371,GO:0051010,GO:0051301,GO:0051310,GO:0051315,GO:0051983 mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|microtubule motor activity|ATP binding|nucleus|cytosol|kinesin complex|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|microtubule depolymerization|sister chromatid cohesion|mitotic metaphase plate congression|cell proliferation|microtubule cytoskeleton|membrane|ATPase activity|centromeric DNA binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|establishment or maintenance of microtubule cytoskeleton polarity|microtubule plus-end|microtubule plus-end binding|cell division|metaphase plate congression|attachment of mitotic spindle microtubules to kinetochore|regulation of chromosome segregation KIF3A 204.016596731204 241.792221259445 166.240972202963 0.68753647796049 -0.540491835651289 0.0595080700137803 0.879410748501007 1.33896 1.15402 1.00735 0.727235 GeneID:11127,Genbank:XM_006714526.4,HGNC:HGNC:6319,MIM:604683 kinesin family member 3A GO:0003777,GO:0005524,GO:0005814,GO:0005874,GO:0005929,GO:0007018,GO:0008017,GO:0010457,GO:0034454,GO:0060271 microtubule motor activity|ATP binding|centriole|microtubule|cilium|microtubule-based movement|microtubule binding|centriole-centriole cohesion|microtubule anchoring at centrosome|cilium assembly hsa04340 Hedgehog signaling pathway KIF3B 2196.34147731281 2168.53406528139 2224.14888934423 1.02564627641928 0.0365332618961676 0.78288856729604 1 12.1534 11.6337 13.9205 10.9462 GeneID:9371,Genbank:NM_004798.3,HGNC:HGNC:6320,MIM:603754 kinesin family member 3B GO:0003777,GO:0005524,GO:0005813,GO:0005819,GO:0005829,GO:0005873,GO:0005874,GO:0005929,GO:0006890,GO:0007018,GO:0007052,GO:0007100,GO:0007368,GO:0008017,GO:0008089,GO:0008574,GO:0015630,GO:0016020,GO:0016939,GO:0017048,GO:0019886,GO:0030496,GO:0030990,GO:0032467,GO:0035735,GO:0070062,GO:0072383,GO:0090307,GO:0097542,GO:1904115 microtubule motor activity|ATP binding|centrosome|spindle|cytosol|plus-end kinesin complex|microtubule|cilium|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|mitotic spindle organization|mitotic centrosome separation|determination of left/right symmetry|microtubule binding|anterograde axonal transport|ATP-dependent microtubule motor activity, plus-end-directed|microtubule cytoskeleton|membrane|kinesin II complex|Rho GTPase binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|intraciliary transport particle|positive regulation of cytokinesis|intraciliary transport involved in cilium assembly|extracellular exosome|plus-end-directed vesicle transport along microtubule|mitotic spindle assembly|ciliary tip|axon cytoplasm KIF3C 1061.74802792426 982.632689838918 1140.86336600959 1.16102728700855 0.215401879498314 0.155497455221799 1 6.54701 6.43149 8.14015 7.1043 GeneID:3797,Genbank:NM_002254.6,HGNC:HGNC:6321,MIM:602845 kinesin family member 3C GO:0003774,GO:0003777,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0005929,GO:0006890,GO:0007018,GO:0008017,GO:0016887,GO:0019886,GO:0035735,GO:0072384,GO:0097542 motor activity|microtubule motor activity|ATP binding|cytosol|kinesin complex|microtubule|cilium|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|microtubule binding|ATPase activity|antigen processing and presentation of exogenous peptide antigen via MHC class II|intraciliary transport involved in cilium assembly|organelle transport along microtubule|ciliary tip KIF4A 3847.48097343447 3802.84263750801 3892.11930936094 1.02347629927475 0.0334776941398464 0.789913047126266 1 25.9592 24.3417 26.8466 24.8284 GeneID:24137,Genbank:NM_012310.4,HGNC:HGNC:13339,MIM:300521 kinesin family member 4A GO:0000281,GO:0003677,GO:0003777,GO:0005524,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0005871,GO:0005876,GO:0006890,GO:0006996,GO:0007018,GO:0008017,GO:0008089,GO:0008574,GO:0016020,GO:0016363,GO:0019886,GO:0030496,GO:0045171,GO:0051256,GO:1904115 mitotic cytokinesis|DNA binding|microtubule motor activity|ATP binding|nucleoplasm|chromosome|cytoplasm|cytosol|kinesin complex|spindle microtubule|retrograde vesicle-mediated transport, Golgi to ER|organelle organization|microtubule-based movement|microtubule binding|anterograde axonal transport|ATP-dependent microtubule motor activity, plus-end-directed|membrane|nuclear matrix|antigen processing and presentation of exogenous peptide antigen via MHC class II|midbody|intercellular bridge|mitotic spindle midzone assembly|axon cytoplasm KIF4B 55.8833998815807 48.2759204194994 63.490879343662 1.31516662534759 0.395245593687853 0.307928725621501 1 0.329118 0.331182 0.489379 0.396167 GeneID:285643,Genbank:NM_001099293.2,HGNC:HGNC:6322,MIM:609184 kinesin family member 4B GO:0000281,GO:0003677,GO:0005524,GO:0005654,GO:0005829,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0008017,GO:0008574,GO:0016363,GO:0019886,GO:0045171,GO:0051256 mitotic cytokinesis|DNA binding|ATP binding|nucleoplasm|cytosol|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|nuclear matrix|antigen processing and presentation of exogenous peptide antigen via MHC class II|intercellular bridge|mitotic spindle midzone assembly KIF5A 150.72525421183 157.031520032747 144.418988390914 0.919681528656136 -0.120793729990181 0.629826815882724 1 0.749119 0.907894 0.743707 0.747953 GeneID:3798,Genbank:NM_004984.3,HGNC:HGNC:6323,MIM:602821 kinesin family member 5A GO:0003774,GO:0005524,GO:0005829,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0007268,GO:0007411,GO:0008017,GO:0008104,GO:0008574,GO:0016020,GO:0016192,GO:0019886,GO:0019894,GO:0030705,GO:0032839,GO:0035253,GO:0043025,GO:0048471,GO:0098971 motor activity|ATP binding|cytosol|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|chemical synaptic transmission|axon guidance|microtubule binding|protein localization|ATP-dependent microtubule motor activity, plus-end-directed|membrane|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|kinesin binding|cytoskeleton-dependent intracellular transport|dendrite cytoplasm|ciliary rootlet|neuronal cell body|perinuclear region of cytoplasm|anterograde dendritic transport of neurotransmitter receptor complex hsa04144,hsa04728 Endocytosis|Dopaminergic synapse KIF5B 975.378415240701 982.74530869594 968.011521785463 0.9850075225187 -0.0217933523904474 0.976698433504734 1 6.55931 5.11389 7.4885 4.2255 GeneID:3799,Genbank:NM_004521.2,HGNC:HGNC:6324,MIM:602809 kinesin family member 5B GO:0003777,GO:0005524,GO:0005815,GO:0005829,GO:0005871,GO:0005874,GO:0007018,GO:0007028,GO:0007411,GO:0008017,GO:0008432,GO:0008574,GO:0016020,GO:0021766,GO:0030705,GO:0031340,GO:0031982,GO:0032230,GO:0035253,GO:0035617,GO:0035774,GO:0042391,GO:0042802,GO:0043268,GO:0044295,GO:0045296,GO:0045335,GO:0047496,GO:0048471,GO:0051642,GO:0071346,GO:0072383,GO:0090316,GO:0099609,GO:1903078,GO:1905152 microtubule motor activity|ATP binding|microtubule organizing center|cytosol|kinesin complex|microtubule|microtubule-based movement|cytoplasm organization|axon guidance|microtubule binding|JUN kinase binding|ATP-dependent microtubule motor activity, plus-end-directed|membrane|hippocampus development|cytoskeleton-dependent intracellular transport|positive regulation of vesicle fusion|vesicle|positive regulation of synaptic transmission, GABAergic|ciliary rootlet|stress granule disassembly|positive regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of membrane potential|identical protein binding|positive regulation of potassium ion transport|axonal growth cone|cadherin binding|phagocytic vesicle|vesicle transport along microtubule|perinuclear region of cytoplasm|centrosome localization|cellular response to interferon-gamma|plus-end-directed vesicle transport along microtubule|positive regulation of intracellular protein transport|microtubule lateral binding|positive regulation of protein localization to plasma membrane|positive regulation of voltage-gated sodium channel activity hsa04144,hsa04728 Endocytosis|Dopaminergic synapse KIF5C 475.587551101416 507.665584799703 443.50951740313 0.87362533660444 -0.194913397439666 0.456754474263409 1 2.18391 1.96623 2.18157 1.46446 GeneID:3800,Genbank:NM_004522.2,HGNC:HGNC:6325,MIM:604593 kinesin family member 5C GO:0003777,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0006996,GO:0007018,GO:0007411,GO:0008017,GO:0008045,GO:0008104,GO:0008574,GO:0030705,GO:0035253,GO:0043005,GO:0051028 microtubule motor activity|ATP binding|cytoplasm|kinesin complex|microtubule|organelle organization|microtubule-based movement|axon guidance|microtubule binding|motor neuron axon guidance|protein localization|ATP-dependent microtubule motor activity, plus-end-directed|cytoskeleton-dependent intracellular transport|ciliary rootlet|neuron projection|mRNA transport hsa04144,hsa04728 Endocytosis|Dopaminergic synapse KIF6 141.882264053331 119.449909561193 164.314618545468 1.37559433195963 0.460055076465439 0.176897363879423 1 0.278491 0.218969 0.470995 0.293102 GeneID:221458,Genbank:NM_001289020.2,HGNC:HGNC:21202,MIM:613919 kinesin family member 6 GO:0001673,GO:0003777,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887 male germ cell nucleus|microtubule motor activity|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity KIF7 460.553869586843 444.265094504426 476.842644669261 1.07332907889416 0.10209246910588 0.555907400188061 1 3.9837 3.30761 3.98423 4.33054 GeneID:374654,Genbank:NM_198525.2,HGNC:HGNC:30497,MIM:611254 kinesin family member 7 GO:0003777,GO:0005524,GO:0005737,GO:0005871,GO:0005929,GO:0007018,GO:0008017,GO:0008574,GO:0036064,GO:0045879,GO:0045880,GO:0097542 microtubule motor activity|ATP binding|cytoplasm|kinesin complex|cilium|microtubule-based movement|microtubule binding|ATP-dependent microtubule motor activity, plus-end-directed|ciliary basal body|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway|ciliary tip hsa04340,hsa05200,hsa05217 Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma KIF9 83.8122950327666 75.0661513928836 92.5584386726496 1.23302496471698 0.30220200988574 0.362714392863036 1 0.258609 0.292977 0.278467 0.322559 GeneID:64147,Genbank:NM_022342.4,HGNC:HGNC:16666,MIM:607910 kinesin family member 9 GO:0002102,GO:0003777,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887,GO:0022617,GO:0031982,GO:0046983,GO:0071801,GO:1903008 podosome|microtubule motor activity|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity|extracellular matrix disassembly|vesicle|protein dimerization activity|regulation of podosome assembly|organelle disassembly KIFAP3 562.640497507106 567.933541584495 557.347453429717 0.981360339934768 -0.0271451264520693 0.897811248516458 1 3.76936 3.25789 3.8175 3.05912 GeneID:22920,Genbank:XM_024454186.1,HGNC:HGNC:17060,MIM:601836 kinesin associated protein 3 GO:0000794,GO:0005783,GO:0005794,GO:0005813,GO:0005829,GO:0005929,GO:0005930,GO:0006461,GO:0006890,GO:0007017,GO:0007018,GO:0007165,GO:0008285,GO:0015630,GO:0016939,GO:0019886,GO:0019894,GO:0030990,GO:0032391,GO:0035735,GO:0036064,GO:0043066,GO:0046587,GO:0070062,GO:0072383,GO:0097542,GO:1990075 condensed nuclear chromosome|endoplasmic reticulum|Golgi apparatus|centrosome|cytosol|cilium|axoneme|protein complex assembly|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based process|microtubule-based movement|signal transduction|negative regulation of cell proliferation|microtubule cytoskeleton|kinesin II complex|antigen processing and presentation of exogenous peptide antigen via MHC class II|kinesin binding|intraciliary transport particle|photoreceptor connecting cilium|intraciliary transport involved in cilium assembly|ciliary basal body|negative regulation of apoptotic process|positive regulation of calcium-dependent cell-cell adhesion|extracellular exosome|plus-end-directed vesicle transport along microtubule|ciliary tip|periciliary membrane compartment KIFC1 3808.65019862176 3730.69257356582 3886.60782367769 1.04179257524906 0.0590680602953908 0.67097560662315 1 37.4872 38.9677 40.0759 41.8043 GeneID:3833,Genbank:XM_017010837.1,HGNC:HGNC:6389,MIM:603763 kinesin family member C1 GO:0000070,GO:0003777,GO:0005524,GO:0005634,GO:0005769,GO:0005815,GO:0005819,GO:0005871,GO:0005874,GO:0007018,GO:0007080,GO:0007283,GO:0008017,GO:0016020,GO:0016887,GO:0051301,GO:0090307 mitotic sister chromatid segregation|microtubule motor activity|ATP binding|nucleus|early endosome|microtubule organizing center|spindle|kinesin complex|microtubule|microtubule-based movement|mitotic metaphase plate congression|spermatogenesis|microtubule binding|membrane|ATPase activity|cell division|mitotic spindle assembly KIFC2 619.237301997376 578.908234527152 659.5663694676 1.1393280145796 0.188183161338933 0.26698967697579 1 6.56892 6.39143 7.42846 7.63086 GeneID:90990,Genbank:XM_011517362.2,HGNC:HGNC:29530,MIM:615216 kinesin family member C2 GO:0003777,GO:0005524,GO:0005737,GO:0005871,GO:0005874,GO:0007018,GO:0008017,GO:0016887 microtubule motor activity|ATP binding|cytoplasm|kinesin complex|microtubule|microtubule-based movement|microtubule binding|ATPase activity KIFC3 2230.63099093782 2275.49612642364 2185.765855452 0.9605667221624 -0.0580422661193356 0.658515446237329 1 9.48452 10.3876 10.562 9.14265 GeneID:3801,Genbank:XM_011523075.1,HGNC:HGNC:6326,MIM:604535 kinesin family member C3 GO:0003777,GO:0005524,GO:0005794,GO:0005813,GO:0005871,GO:0005874,GO:0005915,GO:0007018,GO:0007030,GO:0007601,GO:0008017,GO:0008569,GO:0016887,GO:0030659,GO:0045218,GO:0070062,GO:0090136 microtubule motor activity|ATP binding|Golgi apparatus|centrosome|kinesin complex|microtubule|zonula adherens|microtubule-based movement|Golgi organization|visual perception|microtubule binding|ATP-dependent microtubule motor activity, minus-end-directed|ATPase activity|cytoplasmic vesicle membrane|zonula adherens maintenance|extracellular exosome|epithelial cell-cell adhesion KIN 99.0582355533364 105.555422517863 92.5610485888098 0.876895249726708 -0.189523580296825 0.547912762720231 1 0.436694 0.374144 0.410976 0.40274 GeneID:22944,Genbank:NM_012311.3,HGNC:HGNC:6327,MIM:601720 Kin17 DNA and RNA binding protein GO:0003677,GO:0003690,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006281,GO:0006310,GO:0006397,GO:0006479,GO:0006974,GO:0016032,GO:0016363,GO:0043231,GO:0043234,GO:0046872 DNA binding|double-stranded DNA binding|RNA binding|nucleus|nucleoplasm|cytoplasm|DNA replication|DNA repair|DNA recombination|mRNA processing|protein methylation|cellular response to DNA damage stimulus|viral process|nuclear matrix|intracellular membrane-bounded organelle|protein complex|metal ion binding KIRREL1 6552.95926311593 6264.94908987208 6840.96943635978 1.09194334035673 0.126897998467391 0.339724850440425 1 30.4179 31.0413 37.2517 30.7972 GeneID:55243,Genbank:NM_018240.6,HGNC:HGNC:15734,MIM:607428 kirre like nephrin family adhesion molecule 1 GO:0001933,GO:0005886,GO:0005911,GO:0007411,GO:0007588,GO:0016021,GO:0017022,GO:0030838,GO:0031253,GO:0031295,GO:0043198,GO:0045121,GO:0048471,GO:0070062,GO:0098609 negative regulation of protein phosphorylation|plasma membrane|cell-cell junction|axon guidance|excretion|integral component of membrane|myosin binding|positive regulation of actin filament polymerization|cell projection membrane|T cell costimulation|dendritic shaft|membrane raft|perinuclear region of cytoplasm|extracellular exosome|cell-cell adhesion KIRREL2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0104879 GeneID:84063,Genbank:XM_011527362.1,HGNC:HGNC:18816,MIM:607762 kirre like nephrin family adhesion molecule 2 GO:0001933,GO:0005886,GO:0007155,GO:0016021,GO:0036057,GO:0098609 negative regulation of protein phosphorylation|plasma membrane|cell adhesion|integral component of membrane|slit diaphragm|cell-cell adhesion KIRREL3 19.8369748147946 12.5301340419358 27.1438155876534 2.16628293814006 1.11522168560243 0.0780251195414765 0.94157495521624 0.0936996 0.0570942 0.243413 0.13803 GeneID:84623,Genbank:XM_011543033.1,HGNC:HGNC:23204,MIM:607761 kirre like nephrin family adhesion molecule 3 GO:0001764,GO:0002121,GO:0005576,GO:0005886,GO:0007156,GO:0007416,GO:0016021,GO:0021740,GO:0021766,GO:0030097,GO:0030424,GO:0030425,GO:0043198,GO:0048812,GO:0072102 neuron migration|inter-male aggressive behavior|extracellular region|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|integral component of membrane|principal sensory nucleus of trigeminal nerve development|hippocampus development|hemopoiesis|axon|dendrite|dendritic shaft|neuron projection morphogenesis|glomerulus morphogenesis KISS1 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.168295 0 GeneID:3814,Genbank:NM_002256.3,HGNC:HGNC:6341,MIM:603286 KiSS-1 metastasis suppressor KISS1R 4.03226228126257 6.61105959887042 1.45346496365472 0.219853556289684 -2.18538522551626 0.18618035287629 1 0.212391 0.277793 0.0382368 0.0357841 GeneID:84634,Genbank:XM_017027382.1,HGNC:HGNC:4510,MIM:604161 KISS1 receptor hsa04080 Neuroactive ligand-receptor interaction KIT 37.5266487829345 46.9497850376821 28.103512528187 0.598586607066059 -0.740368094927952 0.116713069714389 1 0.331345 0.291321 0.166609 0.211598 GeneID:3815,Genbank:NM_000222.2,HGNC:HGNC:6342,MIM:164920 KIT proto-oncogene receptor tyrosine kinase hsa04010,hsa04014,hsa04015,hsa04072,hsa04151,hsa04640,hsa04916,hsa05200,hsa05221,hsa05224,hsa05230 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Hematopoietic cell lineage|Melanogenesis|Pathways in cancer|Acute myeloid leukemia|Breast cancer|Central carbon metabolism in cancer KITLG 81.3745232085741 101.673068921781 61.075977495367 0.600709491147097 -0.735260636412231 0.155775441120262 1 0.986848 0.629893 0.648606 0.377346 GeneID:4254,Genbank:NM_003994.5,HGNC:HGNC:6343,MIM:184745 KIT ligand hsa04010,hsa04014,hsa04015,hsa04072,hsa04151,hsa04640,hsa04916,hsa05200 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Hematopoietic cell lineage|Melanogenesis|Pathways in cancer KIZ 70.2356996443361 74.0761999338609 66.3951993548113 0.896309468008515 -0.157931158501224 0.672473234644935 1 0.709607 0.669589 0.617516 0.609127 GeneID:55857,Genbank:NM_001352436.1,HGNC:HGNC:15865,MIM:615757 kizuna centrosomal protein GO:0005737,GO:0005813,GO:0007051,GO:0019901,GO:0042995 cytoplasm|centrosome|spindle organization|protein kinase binding|cell projection KLB 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00701999 0 0 0 GeneID:152831,Genbank:NM_175737.3,HGNC:HGNC:15527,MIM:611135 klotho beta GO:0000165,GO:0004553,GO:0005088,GO:0005104,GO:0005622,GO:0005886,GO:0005887,GO:0005975,GO:0008284,GO:0008543,GO:0016303,GO:0017134,GO:0046934,GO:0051897,GO:0090080,GO:1901657 MAPK cascade|hydrolase activity, hydrolyzing O-glycosyl compounds|Ras guanyl-nucleotide exchange factor activity|fibroblast growth factor receptor binding|intracellular|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|positive regulation of cell proliferation|fibroblast growth factor receptor signaling pathway|1-phosphatidylinositol-3-kinase activity|fibroblast growth factor binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|positive regulation of protein kinase B signaling|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway|glycosyl compound metabolic process hsa04714 Thermogenesis KLC1 2046.26160457715 2063.98821153277 2028.53499762154 0.98282295716946 -0.0249965377492384 0.866301560488476 1 22.0166 21.3591 20.3987 22.4776 GeneID:3831,Genbank:NM_001130107.1,HGNC:HGNC:6387,MIM:600025 kinesin light chain 1 GO:0003774,GO:0003777,GO:0005829,GO:0005871,GO:0005874,GO:0006890,GO:0007018,GO:0016020,GO:0016032,GO:0019886,GO:0030426,GO:0031410,GO:0035617 motor activity|microtubule motor activity|cytosol|kinesin complex|microtubule|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|membrane|viral process|antigen processing and presentation of exogenous peptide antigen via MHC class II|growth cone|cytoplasmic vesicle|stress granule disassembly hsa05132 Salmonella infection KLC2 1920.41068343866 1939.65923926392 1901.16212761339 0.980152641829427 -0.0289216533512827 0.816350731225842 1 17.728 19.0752 18.628 18.1963 GeneID:64837,Genbank:NM_001134775.1,HGNC:HGNC:20716,MIM:611729 kinesin light chain 2 GO:0003777,GO:0005654,GO:0005739,GO:0005829,GO:0005871,GO:0005874,GO:0005886,GO:0006890,GO:0007018,GO:0016020,GO:0016938,GO:0019886,GO:0019894,GO:0043234,GO:0045296 microtubule motor activity|nucleoplasm|mitochondrion|cytosol|kinesin complex|microtubule|plasma membrane|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|membrane|kinesin I complex|antigen processing and presentation of exogenous peptide antigen via MHC class II|kinesin binding|protein complex|cadherin binding hsa05132 Salmonella infection KLC3 66.6383059809686 69.3293733934501 63.9472385684871 0.92236862153046 -0.116584660748946 0.86141055658831 1 0.640183 0.644261 0.414936 0.974136 GeneID:147700,Genbank:NM_177417.2,HGNC:HGNC:20717,MIM:601334 kinesin light chain 3 GO:0003777,GO:0005737,GO:0005871,GO:0005874,GO:0008017,GO:0008088,GO:0019894,GO:0031514,GO:0035253,GO:0043005 microtubule motor activity|cytoplasm|kinesin complex|microtubule|microtubule binding|axo-dendritic transport|kinesin binding|motile cilium|ciliary rootlet|neuron projection hsa05132 Salmonella infection KLC4 462.196690722551 427.190047675927 497.203333769175 1.16389259645478 0.218957933064724 0.215786908937414 1 4.31145 4.06513 4.85166 4.91695 GeneID:89953,Genbank:NM_201521.2,HGNC:HGNC:21624 kinesin light chain 4 GO:0003777,GO:0005737,GO:0005871,GO:0005874 microtubule motor activity|cytoplasm|kinesin complex|microtubule hsa05132 Salmonella infection KLF1 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0.035299 0 0.0319746 0 GeneID:10661,Genbank:NM_006563.4,HGNC:HGNC:6345,MIM:600599 Kruppel like factor 1 GO:0000790,GO:0000987,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0030218,GO:0044212,GO:0045893,GO:0046872,GO:0060135,GO:1901653 nuclear chromatin|proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|erythrocyte differentiation|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|metal ion binding|maternal process involved in female pregnancy|cellular response to peptide KLF10 786.561804161547 837.881363819574 735.242244503519 0.877501608523475 -0.188526324904109 0.238778579845147 1 9.83521 9.71101 9.75746 7.6231 GeneID:7071,Genbank:NM_005655.3,HGNC:HGNC:11810,MIM:601878 Kruppel like factor 10 GO:0000122,GO:0000978,GO:0001046,GO:0001077,GO:0001501,GO:0003700,GO:0005634,GO:0007179,GO:0007267,GO:0007623,GO:0008283,GO:0008285,GO:0009267,GO:0030282,GO:0035019,GO:0042752,GO:0045672,GO:0045892,GO:0045944,GO:0046872,GO:1901653 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|core promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|skeletal system development|DNA binding transcription factor activity|nucleus|transforming growth factor beta receptor signaling pathway|cell-cell signaling|circadian rhythm|cell proliferation|negative regulation of cell proliferation|cellular response to starvation|bone mineralization|somatic stem cell population maintenance|regulation of circadian rhythm|positive regulation of osteoclast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|cellular response to peptide KLF11 318.051381414761 318.165907724785 317.936855104737 0.999280084338118 -0.00103899279373832 0.9973524617914 1 3.23027 3.41385 3.66493 3.09268 GeneID:8462,Genbank:NM_003597.4,HGNC:HGNC:11811,MIM:603301 Kruppel like factor 11 GO:0000083,GO:0000122,GO:0000981,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0006366,GO:0006915,GO:0008285,GO:0016604,GO:0043065,GO:0044212,GO:0046872,GO:1901653 regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|focal adhesion|transcription from RNA polymerase II promoter|apoptotic process|negative regulation of cell proliferation|nuclear body|positive regulation of apoptotic process|transcription regulatory region DNA binding|metal ion binding|cellular response to peptide KLF12 150.721957440928 152.169023632751 149.274891249106 0.980980804670012 -0.0277031880843582 0.936742035219157 1 0.498912 0.45728 0.508421 0.428437 GeneID:11278,Genbank:NM_007249.4,HGNC:HGNC:6346,MIM:607531 Kruppel like factor 12 GO:0000122,GO:0003677,GO:0003700,GO:0003714,GO:0005654,GO:0005829,GO:0006351,GO:0006357,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|metal ion binding KLF13 2123.89754431412 1772.24895889496 2475.54612973329 1.39683881167399 0.48216555044288 0.000611311133565656 0.0714653950013689 11.1492 11.6506 17.1126 15.4164 GeneID:51621,Genbank:NM_001302461.1,HGNC:HGNC:13672,MIM:605328 Kruppel like factor 13 GO:0000978,GO:0000981,GO:0001077,GO:0005634,GO:0006357,GO:0006366,GO:0008285,GO:0045647,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of cell proliferation|negative regulation of erythrocyte differentiation|metal ion binding KLF15 4.68965113284412 2.59443583384164 6.7848664318466 2.61516062310938 1.38689955949202 0.349916852555601 1 0.0566557 0.0327109 0.122498 0.0981607 GeneID:28999,Genbank:NM_014079.3,HGNC:HGNC:14536,MIM:606465 Kruppel like factor 15 GO:0001077,GO:0005634,GO:0010001,GO:0014898,GO:0015758,GO:0044212,GO:0045944,GO:0046872,GO:0072112,GO:2000757 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|glial cell differentiation|cardiac muscle hypertrophy in response to stress|glucose transport|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|glomerular visceral epithelial cell differentiation|negative regulation of peptidyl-lysine acetylation KLF16 1381.95232780243 1374.00153289898 1389.90312270588 1.01157319655485 0.0166007158289916 0.931383521116302 1 27.083 27.6443 28.7684 28.1792 GeneID:83855,Genbank:NM_031918.3,HGNC:HGNC:16857,MIM:606139 Kruppel like factor 16 GO:0000978,GO:0001078,GO:0005634,GO:0006351,GO:0007212,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|transcription, DNA-templated|dopamine receptor signaling pathway|metal ion binding KLF17 12.8163043689366 8.66739775606975 16.9652109818034 1.95735922814004 0.96890855366336 0.241567737026907 1 0.0539251 0.065921 0.0937244 0.0635894 GeneID:128209,Genbank:XM_011540700.1,HGNC:HGNC:18830,MIM:609602 Kruppel like factor 17 GO:0003700,GO:0005634,GO:0006351,GO:0006357,GO:0044212,GO:0046872 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription regulatory region DNA binding|metal ion binding KLF2 144.727678305902 164.92068873875 124.534667873053 0.755118528945317 -0.405224976674663 0.108859423071701 1 3.09619 3.53828 2.26744 2.89201 GeneID:10365,Genbank:NM_016270.3,HGNC:HGNC:6347,MIM:602016 Kruppel like factor 2 hsa04068,hsa04371,hsa05418 FoxO signaling pathway|Apelin signaling pathway|Fluid shear stress and atherosclerosis KLF3 384.381603487044 381.508563090269 387.254643883819 1.01506147266265 0.0215671004351336 0.909564871782048 1 2.59502 2.60574 2.99394 2.26504 GeneID:51274,Genbank:XM_017008279.2,HGNC:HGNC:16516,MIM:609392 Kruppel like factor 3 GO:0000122,GO:0000977,GO:0003700,GO:0005654,GO:0006351,GO:0007275,GO:0046872,GO:1901653 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|multicellular organism development|metal ion binding|cellular response to peptide hsa05202 Transcriptional misregulation in cancer KLF4 45.2467625118192 44.9414731551677 45.5520518684707 1.01358608586761 0.0194686249469443 0.973268611060144 1 0.750918 0.536731 0.594877 0.684919 GeneID:9314,Genbank:NM_004235.5,HGNC:HGNC:6348,MIM:602253 Kruppel like factor 4 hsa04550 Signaling pathways regulating pluripotency of stem cells KLF5 654.63813866654 673.43214617342 635.844131159659 0.944184406361733 -0.0828594385186068 0.61658483539914 1 8.30517 8.48229 8.29822 7.68244 GeneID:688,Genbank:NM_001286818.1,HGNC:HGNC:6349,MIM:602903 Kruppel like factor 5 KLF6 1898.84505412708 1838.59866925623 1959.09143899792 1.06553511201574 0.0915781342715789 0.602209808644516 1 17.0986 17.9314 21.8286 16.0233 GeneID:1316,Genbank:NM_001160124.1,HGNC:HGNC:2235,MIM:602053 Kruppel like factor 6 KLF7 526.451191102793 561.476369464788 491.426012740799 0.87523899395666 -0.192251079866237 0.274390608025959 1 1.32743 1.26481 1.19094 1.05629 GeneID:8609,Genbank:NM_001270943.1,HGNC:HGNC:6350,MIM:604865 Kruppel like factor 7 GO:0000978,GO:0001077,GO:0003700,GO:0003713,GO:0005634,GO:0006357,GO:0007411,GO:0008270,GO:0045944,GO:0048813 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|transcription coactivator activity|nucleus|regulation of transcription from RNA polymerase II promoter|axon guidance|zinc ion binding|positive regulation of transcription from RNA polymerase II promoter|dendrite morphogenesis KLF8 15.4582231249614 14.4423933750803 16.4740528748424 1.14067332518914 0.189885680663139 0.826207295118547 1 0.0524025 0.0455319 0.0376671 0.0703123 GeneID:11279,Genbank:NM_001324105.1,HGNC:HGNC:6351,MIM:300286 Kruppel like factor 8 GO:0000122,GO:0000978,GO:0001078,GO:0005654,GO:0005829,GO:0006351,GO:0016235,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleoplasm|cytosol|transcription, DNA-templated|aggresome|metal ion binding KLF9 292.268908438441 300.033265852363 284.504551024519 0.948243356336742 -0.0766707362651471 0.718396332130725 1 2.71594 2.60296 2.9014 2.23296 GeneID:687,Genbank:NM_001206.2,HGNC:HGNC:1123,MIM:602902 Kruppel like factor 9 GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006351,GO:0006357,GO:0007623,GO:0010839,GO:0046872,GO:0071387,GO:0097067 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|circadian rhythm|negative regulation of keratinocyte proliferation|metal ion binding|cellular response to cortisol stimulus|cellular response to thyroid hormone stimulus KLHDC1 8.49958589239038 8.76345030543964 8.23572147934112 0.939780701926165 -0.0896039520911665 1 1 0.0382971 0.0318657 0.0263951 0.0393933 GeneID:122773,Genbank:XM_024449471.1,HGNC:HGNC:19836,MIM:611281 kelch domain containing 1 GO:0005829 cytosol KLHDC10 1487.67487389956 1285.81708951113 1689.532658288 1.31397589289342 0.393938807226334 0.0063035072940677 0.316479538626295 8.79459 8.56076 12.7325 10.4499 GeneID:23008,Genbank:NM_014997.3,HGNC:HGNC:22194,MIM:615152 kelch domain containing 10 GO:0005654,GO:0005737 nucleoplasm|cytoplasm KLHDC2 586.225090742597 596.714501131888 575.735680353306 0.96484278371183 -0.0516342132708747 0.730546328790549 1 5.58042 7.17515 5.96888 5.77491 GeneID:23588,Genbank:XM_006720094.4,HGNC:HGNC:20231,MIM:611280 kelch domain containing 2 GO:0005634,GO:0016604,GO:0031965 nucleus|nuclear body|nuclear membrane KLHDC3 2405.93473424008 1988.9339027967 2822.93556568346 1.41932095466523 0.505200866597734 0.000293034390341074 0.0451272961125255 35.4727 36.2648 53.628 51.7736 GeneID:116138,Genbank:NM_057161.3,HGNC:HGNC:20704,MIM:611248 kelch domain containing 3 GO:0000790,GO:0003682,GO:0005654,GO:0005737,GO:0005829,GO:0007131,GO:0036498 nuclear chromatin|chromatin binding|nucleoplasm|cytoplasm|cytosol|reciprocal meiotic recombination|IRE1-mediated unfolded protein response KLHDC4 793.029625867127 802.934440803148 783.124810931105 0.975328459130203 -0.0360399410939593 0.802492746611929 1 3.19263 3.51728 3.10845 3.2243 GeneID:54758,Genbank:XM_006721204.4,HGNC:HGNC:25272 kelch domain containing 4 KLHDC7A 5.76021416863533 8.12930007942745 3.3911282578432 0.417148859644758 -1.26136579335575 0.32827542066104 1 0.0483675 0.071846 0.0150819 0.0353077 GeneID:127707,Genbank:NM_152375.2,HGNC:HGNC:26791 kelch domain containing 7A GO:0016021,GO:0016567,GO:0031463 integral component of membrane|protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHDC7B 3.15120402270981 0 6.30240804541962 Inf Inf 0.0333482086492369 0.722740067288468 0 0 0.0798389 0.0377152 GeneID:113730,Genbank:NM_138433.4,HGNC:HGNC:25145 kelch domain containing 7B GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHDC8A 23.7113455654967 16.4026789829097 31.0200121480838 1.891155230216 0.919267787756958 0.118722802220678 1 0.184562 0.184997 0.3933 0.2982 GeneID:55220,Genbank:XM_024448121.1,HGNC:HGNC:25573,MIM:614503 kelch domain containing 8A GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHDC8B 257.267714239622 233.462024427025 281.073404052219 1.20393629217447 0.267759052067962 0.20752119867596 1 3.23199 3.55203 4.28884 4.83712 GeneID:200942,Genbank:XM_005264940.4,HGNC:HGNC:28557,MIM:613169 kelch domain containing 8B GO:0005829,GO:0007049,GO:0016567,GO:0030496,GO:0031463,GO:0051301 cytosol|cell cycle|protein ubiquitination|midbody|Cul3-RING ubiquitin ligase complex|cell division KLHDC9 13.5742055167564 6.31309329565283 20.83531773786 3.30033420418594 1.72261212456457 0.0292492951809872 0.677045321871968 0.437862 0.0841551 0.674872 0.754814 GeneID:126823,Genbank:NM_001007255.2,HGNC:HGNC:28489,MIM:617375 kelch domain containing 9 GO:0030332 cyclin binding KLHL10 1.24125200715389 1.02816907859967 1.45433493570811 1.4144900541931 0.500282032643154 1 1 0.0181016 0.0165381 0.0171861 0.0159426 GeneID:317719,Genbank:NM_001329595.1,HGNC:HGNC:18829,MIM:608778 kelch like family member 10 GO:0000902,GO:0005737,GO:0007286,GO:0008584,GO:0009566,GO:0016567,GO:0031463,GO:0048808,GO:0048873 cell morphogenesis|cytoplasm|spermatid development|male gonad development|fertilization|protein ubiquitination|Cul3-RING ubiquitin ligase complex|male genitalia morphogenesis|homeostasis of number of cells within a tissue KLHL11 176.893368719326 190.931673661212 162.85506377744 0.852949438166076 -0.229467872064867 0.404826303023945 1 1.40295 1.12628 1.27353 0.915826 GeneID:55175,Genbank:NM_018143.2,HGNC:HGNC:19008 kelch like family member 11 GO:0005634,GO:0005737,GO:0005829,GO:0019005,GO:0030162,GO:0031625,GO:0042787,GO:0043161,GO:0043687 nucleus|cytoplasm|cytosol|SCF ubiquitin ligase complex|regulation of proteolysis|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification KLHL12 804.530130360434 790.999222366793 818.061038354076 1.03421219038157 0.0485322152514613 0.767008183667146 1 7.14315 7.55634 7.99511 7.46129 GeneID:59349,Genbank:NM_001303051.1,HGNC:HGNC:19360,MIM:614522 kelch like family member 12 GO:0000139,GO:0005815,GO:0005829,GO:0006513,GO:0006888,GO:0014029,GO:0014032,GO:0016055,GO:0030127,GO:0030134,GO:0031463,GO:0042802,GO:0043231,GO:0048208,GO:0090090 Golgi membrane|microtubule organizing center|cytosol|protein monoubiquitination|ER to Golgi vesicle-mediated transport|neural crest formation|neural crest cell development|Wnt signaling pathway|COPII vesicle coat|COPII-coated ER to Golgi transport vesicle|Cul3-RING ubiquitin ligase complex|identical protein binding|intracellular membrane-bounded organelle|COPII vesicle coating|negative regulation of canonical Wnt signaling pathway KLHL13 1126.1427398255 1033.45400281672 1218.83147683428 1.17937660845311 0.238024485398162 0.107689546644367 1 7.19005 6.78679 8.44066 8.14475 GeneID:90293,Genbank:NM_001168301.1,HGNC:HGNC:22931,MIM:300655 kelch like family member 13 GO:0000910,GO:0005829,GO:0016567,GO:0030496,GO:0031463,GO:0043687 cytokinesis|cytosol|protein ubiquitination|midbody|Cul3-RING ubiquitin ligase complex|post-translational protein modification hsa04120 Ubiquitin mediated proteolysis KLHL14 1.26776669418146 1.56626675524197 0.969266633120943 0.61883879605885 -0.692364450254232 0.974556248291384 1 0 0.00478814 0.00479115 0.0044577 GeneID:57565,Genbank:NM_020805.2,HGNC:HGNC:29266,MIM:613772 kelch like family member 14 GO:0005783,GO:0005789,GO:0005829,GO:0015629,GO:0016235,GO:0016567,GO:0031463,GO:0043005,GO:0043025 endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|actin cytoskeleton|aggresome|protein ubiquitination|Cul3-RING ubiquitin ligase complex|neuron projection|neuronal cell body KLHL15 120.416396979059 120.151703372106 120.681090586011 1.00440599008626 0.0063425377064961 0.995025662869609 1 0.905418 0.918808 1.02936 0.800814 GeneID:80311,Genbank:NM_030624.2,HGNC:HGNC:29347,MIM:300980 kelch like family member 15 GO:0005634,GO:0031463,GO:0042787,GO:0071630,GO:2000042 nucleus|Cul3-RING ubiquitin ligase complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|nuclear protein quality control by the ubiquitin-proteasome system|negative regulation of double-strand break repair via homologous recombination KLHL17 357.25629034583 359.782742270729 354.72983842093 0.985955680314436 -0.0204052973994233 0.917202159813356 1 4.23229 3.76689 3.73912 4.23257 GeneID:339451,Genbank:XM_006710600.3,HGNC:HGNC:24023 kelch like family member 17 GO:0005615,GO:0007420,GO:0014069,GO:0015629,GO:0016567,GO:0030036,GO:0030054,GO:0031208,GO:0031463,GO:0032839,GO:0032947,GO:0043025,GO:0045211,GO:0051015 extracellular space|brain development|postsynaptic density|actin cytoskeleton|protein ubiquitination|actin cytoskeleton organization|cell junction|POZ domain binding|Cul3-RING ubiquitin ligase complex|dendrite cytoplasm|protein complex scaffold activity|neuronal cell body|postsynaptic membrane|actin filament binding KLHL18 1024.08288997787 992.137168575703 1056.02861138004 1.06439779178524 0.0900374224402796 0.57581072087551 1 7.36815 8.12717 8.7234 8.23947 GeneID:23276,Genbank:NM_025010.4,HGNC:HGNC:29120 kelch like family member 18 GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL2 451.897513025538 494.26116915833 409.533856892746 0.828577850026405 -0.271290840928177 0.132566748454188 1 4.33324 4.23936 4.24545 3.38479 GeneID:11275,Genbank:NM_007246.3,HGNC:HGNC:6353,MIM:605774 kelch like family member 2 GO:0001726,GO:0003779,GO:0005737,GO:0005829,GO:0015629,GO:0016567,GO:0030027,GO:0031463,GO:0042787,GO:0042802,GO:0043687 ruffle|actin binding|cytoplasm|cytosol|actin cytoskeleton|protein ubiquitination|lamellipodium|Cul3-RING ubiquitin ligase complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|identical protein binding|post-translational protein modification KLHL20 405.246837452519 427.612475492983 382.881199412054 0.895392958240145 -0.159407122582882 0.401836407709094 1 4.08747 3.47436 3.75268 3.15122 GeneID:27252,Genbank:XM_024446472.1,HGNC:HGNC:25056,MIM:617679 kelch like family member 20 GO:0003779,GO:0004842,GO:0005737,GO:0005802,GO:0005829,GO:0006895,GO:0015031,GO:0016567,GO:0016605,GO:0019964,GO:0030424,GO:0030425,GO:0031463,GO:0035455,GO:0043066,GO:0043161,GO:0048471,GO:1990390 actin binding|ubiquitin-protein transferase activity|cytoplasm|trans-Golgi network|cytosol|Golgi to endosome transport|protein transport|protein ubiquitination|PML body|interferon-gamma binding|axon|dendrite|Cul3-RING ubiquitin ligase complex|response to interferon-alpha|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|perinuclear region of cytoplasm|protein K33-linked ubiquitination KLHL21 2625.03156888753 2621.95190529301 2628.11123248205 1.00234913812744 0.00338511542984942 0.995162524787428 1 24.8982 26.508 26.6701 25.9582 GeneID:9903,Genbank:NM_014851.3,HGNC:HGNC:29041,MIM:616262 kelch like family member 21 GO:0005827,GO:0005829,GO:0007049,GO:0016567,GO:0031463,GO:0032465,GO:0035853,GO:0043687,GO:0051301 polar microtubule|cytosol|cell cycle|protein ubiquitination|Cul3-RING ubiquitin ligase complex|regulation of cytokinesis|chromosome passenger complex localization to spindle midzone|post-translational protein modification|cell division KLHL22 608.919685031609 572.345201202966 645.494168860252 1.12780568003984 0.173518514019479 0.307926719307794 1 2.461 2.72432 2.90426 3.05888 GeneID:84861,Genbank:XM_017029018.2,HGNC:HGNC:25888 kelch like family member 22 GO:0000070,GO:0005737,GO:0005813,GO:0005827,GO:0005829,GO:0006513,GO:0007094,GO:0031463,GO:0043687,GO:0051301,GO:0072686 mitotic sister chromatid segregation|cytoplasm|centrosome|polar microtubule|cytosol|protein monoubiquitination|mitotic spindle assembly checkpoint|Cul3-RING ubiquitin ligase complex|post-translational protein modification|cell division|mitotic spindle KLHL23 2.19988322341124 3.43049981370153 0.969266633120943 0.282543852429217 -1.82345329542216 0.575768906242816 1 3.43659 3.54772 3.00725 1.8902 GeneID:151230,Genbank:NM_144711.5,HGNC:HGNC:27506 kelch like family member 23 GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL24 328.599502424747 315.984091052892 341.214913796601 1.07984839572029 0.110828780819119 0.557753812600297 1 1.30634 1.22371 1.57469 1.16308 GeneID:54800,Genbank:XM_024453607.1,HGNC:HGNC:25947,MIM:611295 kelch like family member 24 GO:0005737,GO:0005912,GO:0016567,GO:0030057,GO:0030424,GO:0031463,GO:0043204,GO:0045109,GO:0051865,GO:2000312 cytoplasm|adherens junction|protein ubiquitination|desmosome|axon|Cul3-RING ubiquitin ligase complex|perikaryon|intermediate filament organization|protein autoubiquitination|regulation of kainate selective glutamate receptor activity KLHL25 210.879225249906 222.574592379485 199.183858120327 0.894908336081427 -0.160188177709617 0.487971449421634 1 2.81141 2.46578 2.52061 2.32843 GeneID:64410,Genbank:NM_022480.3,HGNC:HGNC:25732 kelch like family member 25 GO:0005737,GO:0005829,GO:0006446,GO:0016567,GO:0031463,GO:0042787,GO:0043687 cytoplasm|cytosol|regulation of translational initiation|protein ubiquitination|Cul3-RING ubiquitin ligase complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|post-translational protein modification KLHL26 271.358471604521 264.537419503332 278.179523705711 1.05156965781246 0.0725444198766766 0.725054207766858 1 4.00333 3.32474 4.0782 3.71916 GeneID:55295,Genbank:NM_001345982.1,HGNC:HGNC:25623 kelch like family member 26 GO:0005737,GO:0007286,GO:0008584,GO:0009566,GO:0016567,GO:0031463 cytoplasm|spermatid development|male gonad development|fertilization|protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL28 44.9862095672767 50.2263973722209 39.7460217623324 0.791337301534493 -0.337635331255514 0.457638987669652 1 0.290977 0.230097 0.24854 0.193754 GeneID:54813,Genbank:NM_017658.4,HGNC:HGNC:19741 kelch like family member 28 GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL29 147.198845622283 157.713696533444 136.683994711121 0.866659001186596 -0.206463637850877 0.416931204440008 1 0.8589 0.870596 0.929611 0.681327 GeneID:114818,Genbank:NM_052920.1,HGNC:HGNC:29404 kelch like family member 29 GO:0031463,GO:0042787 Cul3-RING ubiquitin ligase complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process KLHL3 20.6813179554829 21.0054266992657 20.3572092117 0.969140475133104 -0.0452222980918062 0.983139427810455 1 0.102465 0.100433 0.126127 0.0800477 GeneID:26249,Genbank:NM_017415.2,HGNC:HGNC:6354,MIM:605775 kelch like family member 3 GO:0003779,GO:0005198,GO:0005829,GO:0005856,GO:0016567,GO:0031463,GO:0042787,GO:0043687,GO:0050801,GO:0070294,GO:0070936,GO:0072156 actin binding|structural molecule activity|cytosol|cytoskeleton|protein ubiquitination|Cul3-RING ubiquitin ligase complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|post-translational protein modification|ion homeostasis|renal sodium ion absorption|protein K48-linked ubiquitination|distal tubule morphogenesis KLHL30 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0141915 0 0.0130499 0 GeneID:377007,Genbank:NM_198582.3,HGNC:HGNC:24770 kelch like family member 30 GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL31 3.75114068054263 3.6226049124413 3.87967644864396 1.07096317219683 0.0989088701885283 1 1 0.0187077 0.0179411 0.0420244 0.00558898 GeneID:401265,Genbank:NM_001003760.4,HGNC:HGNC:21353,MIM:610749 kelch like family member 31 GO:0006351,GO:0006355,GO:0031463,GO:0042787 transcription, DNA-templated|regulation of transcription, DNA-templated|Cul3-RING ubiquitin ligase complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process KLHL32 14.0620290291537 16.0086601303222 12.1153979279851 0.756802744849154 -0.402010773687484 0.63749742754952 1 0.0480292 0.0394355 0.0285703 0.0232579 GeneID:114792,Genbank:NM_001323258.1,HGNC:HGNC:21221 kelch like family member 32 GO:0005737,GO:0007286,GO:0008584,GO:0009566,GO:0016567,GO:0031463 cytoplasm|spermatid development|male gonad development|fertilization|protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL33 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0162697 0 0 0 GeneID:123103,Genbank:XM_005267347.5,HGNC:HGNC:31952 kelch like family member 33 GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL36 1109.7113029572 1088.77525330896 1130.64735260545 1.03845798218616 0.0544428434160527 0.735285889115267 1 6.05184 6.51839 6.82514 6.25312 GeneID:79786,Genbank:NM_024731.3,HGNC:HGNC:17844 kelch like family member 36 GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL38 3.87490450854509 4.84287908978074 2.90692992730943 0.60024829722541 -0.736368689039653 0.816365163445494 1 0.0647999 0 0.0242857 0.04546 GeneID:340359,Genbank:XM_005250901.5,HGNC:HGNC:34435 kelch like family member 38 GO:0016567,GO:0031463 protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL4 111.626228159836 107.90972697828 115.342729341392 1.06888167147905 0.0961021510759995 0.742120084932598 1 0.687613 0.695686 0.789926 0.715777 GeneID:56062,Genbank:NM_019117.4,HGNC:HGNC:6355,MIM:300348 kelch like family member 4 GO:0003779,GO:0005737,GO:0005815,GO:0015630,GO:0016567,GO:0031463 actin binding|cytoplasm|microtubule organizing center|microtubule cytoskeleton|protein ubiquitination|Cul3-RING ubiquitin ligase complex KLHL41 2.72210162988957 1.56626675524197 3.87793650453717 2.47591062732993 1.3079592386899 0.556418541563416 1 0.0361311 0.0175195 0.0874496 0.0485807 GeneID:10324,Genbank:NM_006063.2,HGNC:HGNC:16905,MIM:607701 kelch like family member 41 GO:0001726,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0005856,GO:0005886,GO:0006941,GO:0016567,GO:0030239,GO:0031143,GO:0031275,GO:0031430,GO:0031463,GO:0033017,GO:0035914,GO:0043687,GO:0045214,GO:0045661,GO:0048741,GO:2000291,GO:2001014 ruffle|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|cytoskeleton|plasma membrane|striated muscle contraction|protein ubiquitination|myofibril assembly|pseudopodium|regulation of lateral pseudopodium assembly|M band|Cul3-RING ubiquitin ligase complex|sarcoplasmic reticulum membrane|skeletal muscle cell differentiation|post-translational protein modification|sarcomere organization|regulation of myoblast differentiation|skeletal muscle fiber development|regulation of myoblast proliferation|regulation of skeletal muscle cell differentiation KLHL42 673.434928924598 666.359424137062 680.510433712135 1.02123630140505 0.0303167265692045 0.881660252021221 1 4.31128 4.16459 5.22914 3.54313 GeneID:57542,Genbank:XM_017019698.2,HGNC:HGNC:29252 kelch like family member 42 GO:0000209,GO:0005819,GO:0005829,GO:0007049,GO:0031463,GO:0032886,GO:0043161,GO:0043687,GO:0051301 protein polyubiquitination|spindle|cytosol|cell cycle|Cul3-RING ubiquitin ligase complex|regulation of microtubule-based process|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|cell division KLHL5 2070.99657165051 2198.12064584246 1943.87249745856 0.884333851799813 -0.177336979332309 0.210484335376757 1 5.74599 5.64585 5.27608 4.85753 GeneID:51088,Genbank:XM_024454075.1,HGNC:HGNC:6356,MIM:608064 kelch like family member 5 GO:0003779,GO:0005737,GO:0005829,GO:0005856,GO:0016567,GO:0031463,GO:0043687 actin binding|cytoplasm|cytosol|cytoskeleton|protein ubiquitination|Cul3-RING ubiquitin ligase complex|post-translational protein modification KLHL6 1.48335117242078 1.02816907859967 1.93853326624189 1.88542264749112 0.914887962799843 0.868258168018795 1 0.00538745 0.00501261 0.00513375 0.00478717 GeneID:89857,Genbank:NM_130446.3,HGNC:HGNC:18653,MIM:614214 kelch like family member 6 GO:0000976,GO:0002467,GO:0003700,GO:0005634,GO:0005737,GO:0006357,GO:0045893,GO:0050853 transcription regulatory region sequence-specific DNA binding|germinal center formation|DNA binding transcription factor activity|nucleus|cytoplasm|regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-templated|B cell receptor signaling pathway KLHL7 713.656394699001 714.885284585094 712.427504812908 0.996561994175593 -0.00496853979018239 0.988798124372258 1 5.72033 5.53905 5.86768 5.40366 GeneID:55975,Genbank:NM_001031710.2,HGNC:HGNC:15646,MIM:611119 kelch like family member 7 GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0016567,GO:0031463,GO:0042802,GO:0042803,GO:0048471 nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|protein ubiquitination|Cul3-RING ubiquitin ligase complex|identical protein binding|protein homodimerization activity|perinuclear region of cytoplasm KLHL8 169.092101852581 194.218094650859 143.966109054302 0.741260021694201 -0.431948390134909 0.196038081678969 1 1.58212 1.34891 1.34491 0.749612 GeneID:57563,Genbank:NM_001292007.1,HGNC:HGNC:18644,MIM:611967 kelch like family member 8 GO:0005654,GO:0016567,GO:0031463,GO:0042787 nucleoplasm|protein ubiquitination|Cul3-RING ubiquitin ligase complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process KLHL9 719.106769137062 726.251962378628 711.961575895495 0.980323101040128 -0.0286707747984963 0.892752936735914 1 6.09928 5.40483 6.1697 5.08328 GeneID:55958,Genbank:NM_018847.3,HGNC:HGNC:18732,MIM:611201 kelch like family member 9 GO:0000910,GO:0005829,GO:0016567,GO:0030496,GO:0031463,GO:0043687 cytokinesis|cytosol|protein ubiquitination|midbody|Cul3-RING ubiquitin ligase complex|post-translational protein modification hsa04120 Ubiquitin mediated proteolysis KLK1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:3816,Genbank:NM_002257.3,HGNC:HGNC:6357,MIM:147910 kallikrein 1 hsa04614,hsa04961 Renin-angiotensin system|Endocrine and other factor-regulated calcium reabsorption KLK14 1.75283499676863 1.56626675524197 1.93940323829528 1.23823303521223 0.308282855026159 1 1 0 0.0307931 0.0325319 0 GeneID:43847,Genbank:NM_001311182.1,HGNC:HGNC:6362,MIM:606135 kallikrein related peptidase 14 GO:0004252,GO:0005576,GO:0005615,GO:0006508,GO:0009566,GO:0045744,GO:0045745,GO:0048730,GO:0070062,GO:0070268,GO:0070684 serine-type endopeptidase activity|extracellular region|extracellular space|proteolysis|fertilization|negative regulation of G-protein coupled receptor protein signaling pathway|positive regulation of G-protein coupled receptor protein signaling pathway|epidermis morphogenesis|extracellular exosome|cornification|seminal clot liquefaction KLK15 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0151981 0 0 GeneID:55554,Genbank:XM_011527089.2,HGNC:HGNC:20453,MIM:610601 kallikrein related peptidase 15 GO:0004252,GO:0005576,GO:0008236 serine-type endopeptidase activity|extracellular region|serine-type peptidase activity KLKB1 1.26820168020816 1.56626675524197 0.97013660517434 0.619394239153384 -0.691070129994731 0.974558099637673 1 0.011601 0.0110153 0.0223145 0 GeneID:3818,Genbank:XM_017008181.1,HGNC:HGNC:6371,MIM:229000 kallikrein B1 hsa04610 Complement and coagulation cascades KLLN 13.8035168358799 12.0978975697713 15.5091361019885 1.28196953334609 0.35836197598723 0.700471573793977 1 0.083629 0.17563 0.192107 0.158065 GeneID:100144748,Genbank:NM_001126049.1,HGNC:HGNC:37212,MIM:612105 killin, p53 regulated DNA replication inhibitor GO:0003677,GO:0005634,GO:0005730,GO:0006915,GO:0007050 DNA binding|nucleus|nucleolus|apoptotic process|cell cycle arrest KLRB1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:3820,Genbank:NM_002258.2,HGNC:HGNC:6373,MIM:602890 killer cell lectin like receptor B1 hsa05144 Malaria KLRC3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0440553 0 0 0 GeneID:3823,Genbank:NM_002261.2,HGNC:HGNC:6376,MIM:602892 killer cell lectin like receptor C3 hsa04612,hsa04650 Antigen processing and presentation|Natural killer cell mediated cytotoxicity KLRC4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:8302,Genbank:NM_013431.2,HGNC:HGNC:6377,MIM:602893 killer cell lectin like receptor C4 GO:0006968,GO:0016021 cellular defense response|integral component of membrane hsa04612,hsa04650 Antigen processing and presentation|Natural killer cell mediated cytotoxicity KLRD1 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.00790745 0.007951 0 GeneID:3824,Genbank:NM_001351060.1,HGNC:HGNC:6378,MIM:602894 killer cell lectin like receptor D1 hsa04612,hsa04650,hsa05332 Antigen processing and presentation|Natural killer cell mediated cytotoxicity|Graft-versus-host disease KLRF1 4.64706294355607 3.47852608838648 5.81559979872566 1.6718574623148 0.741451852695477 0.67528049998935 1 0.0297648 0.146455 0.115596 0.134291 GeneID:51348,Genbank:XM_017019415.1,HGNC:HGNC:13342,MIM:605029 killer cell lectin like receptor F1 KLRG1 19.7708454013656 23.5518362584224 15.9898545443087 0.678921777854603 -0.558682731318774 0.392115810240186 1 0.135133 0.193504 0.119163 0.141077 GeneID:10219,Genbank:NM_001329102.1,HGNC:HGNC:6380,MIM:604874 killer cell lectin like receptor G1 GO:0004872,GO:0005886,GO:0006954,GO:0006968,GO:0007166,GO:0016021,GO:0030246,GO:0043231,GO:0045087 receptor activity|plasma membrane|inflammatory response|cellular defense response|cell surface receptor signaling pathway|integral component of membrane|carbohydrate binding|intracellular membrane-bounded organelle|innate immune response KMO 41.0133946041209 47.1418901364219 34.88489907182 0.739997886611421 -0.434406944388446 0.413354295669588 1 0.336578 0.186152 0.126108 0.253262 GeneID:8564,Genbank:XM_005273338.3,HGNC:HGNC:6381,MIM:603538 kynurenine 3-monooxygenase GO:0004502,GO:0005741,GO:0005743,GO:0005829,GO:0006569,GO:0009435,GO:0009651,GO:0016021,GO:0016174,GO:0019441,GO:0019674,GO:0019805,GO:0044550,GO:0050660,GO:0070062,GO:0070189,GO:0071949 kynurenine 3-monooxygenase activity|mitochondrial outer membrane|mitochondrial inner membrane|cytosol|tryptophan catabolic process|NAD biosynthetic process|response to salt stress|integral component of membrane|NAD(P)H oxidase activity|tryptophan catabolic process to kynurenine|NAD metabolic process|quinolinate biosynthetic process|secondary metabolite biosynthetic process|flavin adenine dinucleotide binding|extracellular exosome|kynurenine metabolic process|FAD binding hsa00380 Tryptophan metabolism KMT2A 1130.2873709561 1084.06562738727 1176.50911452493 1.08527480698789 0.118060399793625 0.787268829007711 1 2.08151 2.08374 3.03855 1.54868 GeneID:4297,Genbank:NM_001197104.1,HGNC:HGNC:7132,MIM:159555 lysine methyltransferase 2A hsa00310,hsa04934,hsa05202 Lysine degradation|Cushing syndrome|Transcriptional misregulation in cancer KMT2B 1171.33033463496 1171.77961668339 1170.88105258653 0.999233162888251 -0.00110673649585268 0.960341295160459 1 4.33067 4.7548 4.83228 4.43792 GeneID:9757,Genbank:XM_011527562.2,HGNC:HGNC:15840,MIM:606834 lysine methyltransferase 2B GO:0001541,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0007613,GO:0008270,GO:0009994,GO:0016458,GO:0018024,GO:0030728,GO:0035097,GO:0042800,GO:0045652,GO:0048096,GO:0051568,GO:0051569,GO:0080182 ovarian follicle development|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|memory|zinc ion binding|oocyte differentiation|gene silencing|histone-lysine N-methyltransferase activity|ovulation|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|regulation of megakaryocyte differentiation|chromatin-mediated maintenance of transcription|histone H3-K4 methylation|regulation of histone H3-K4 methylation|histone H3-K4 trimethylation hsa00310 Lysine degradation KMT2C 845.89557806076 778.966934380213 912.824221741307 1.1718394985117 0.228774983959827 0.651323252249055 1 1.45782 1.20448 2.17159 0.991222 GeneID:58508,Genbank:XM_011516456.2,HGNC:HGNC:13726,MIM:606833 lysine methyltransferase 2C GO:0003677,GO:0003723,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0016746,GO:0018024,GO:0035097,GO:0042800,GO:0044666,GO:0045652,GO:0046872 DNA binding|RNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|transferase activity, transferring acyl groups|histone-lysine N-methyltransferase activity|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|MLL3/4 complex|regulation of megakaryocyte differentiation|metal ion binding hsa00310 Lysine degradation KMT2D 2308.04527043351 2228.02684401868 2388.06369684834 1.0718289607952 0.100074703277104 0.632686391046675 1 3.78561 3.94184 4.92466 3.4902 GeneID:8085,Genbank:XM_006719614.4,HGNC:HGNC:7133,MIM:602113 lysine methyltransferase 2D GO:0001555,GO:0003677,GO:0005634,GO:0005654,GO:0006342,GO:0006351,GO:0006355,GO:0008284,GO:0018024,GO:0033148,GO:0035097,GO:0042800,GO:0043627,GO:0044212,GO:0044666,GO:0045652,GO:0045944,GO:0046872,GO:0048477,GO:0051568,GO:1904837 oocyte growth|DNA binding|nucleus|nucleoplasm|chromatin silencing|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of cell proliferation|histone-lysine N-methyltransferase activity|positive regulation of intracellular estrogen receptor signaling pathway|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|response to estrogen|transcription regulatory region DNA binding|MLL3/4 complex|regulation of megakaryocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|oogenesis|histone H3-K4 methylation|beta-catenin-TCF complex assembly hsa00310,hsa04934 Lysine degradation|Cushing syndrome KMT2E 553.040095157976 565.137191996806 540.942998319146 0.957188813583169 -0.0631245583143259 0.844212300499628 1 1.96445 1.70481 2.16867 1.40876 GeneID:55904,Genbank:XM_024446837.1,HGNC:HGNC:18541,MIM:608444 lysine methyltransferase 2E GO:0002446,GO:0005654,GO:0005737,GO:0005886,GO:0006306,GO:0006351,GO:0006355,GO:0007050,GO:0016607,GO:0018024,GO:0030218,GO:0042119,GO:0045652,GO:0046872 neutrophil mediated immunity|nucleoplasm|cytoplasm|plasma membrane|DNA methylation|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle arrest|nuclear speck|histone-lysine N-methyltransferase activity|erythrocyte differentiation|neutrophil activation|regulation of megakaryocyte differentiation|metal ion binding hsa00310 Lysine degradation KMT5A 1748.12431868178 1835.47594440085 1660.7726929627 0.904818555660681 -0.144299579037584 0.308899383470278 1 19.137 19.74 17.8164 17.5757 GeneID:387893,Genbank:NM_020382.4,HGNC:HGNC:29489,MIM:607240 lysine methyltransferase 5A GO:0000122,GO:0002039,GO:0003714,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006351,GO:0007049,GO:0016278,GO:0016279,GO:0018024,GO:0018026,GO:0042799,GO:0043516,GO:0045892,GO:0051301,GO:1901796 negative regulation of transcription from RNA polymerase II promoter|p53 binding|transcription corepressor activity|nucleus|nucleoplasm|chromosome|cytosol|transcription, DNA-templated|cell cycle|lysine N-methyltransferase activity|protein-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|histone methyltransferase activity (H4-K20 specific)|regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of transcription, DNA-templated|cell division|regulation of signal transduction by p53 class mediator hsa00310 Lysine degradation KMT5B 221.129152663913 228.993546879616 213.264758448209 0.931313398802127 -0.102661360171102 0.652473066804719 1 0.961886 0.990902 0.977428 0.747463 GeneID:51111,Genbank:XM_005274036.4,HGNC:HGNC:24283,MIM:610881 lysine methyltransferase 5B GO:0000780,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0007517,GO:0018024,GO:0034773,GO:0042799 condensed nuclear chromosome, centromeric region|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|muscle organ development|histone-lysine N-methyltransferase activity|histone H4-K20 trimethylation|histone methyltransferase activity (H4-K20 specific) hsa00310 Lysine degradation KMT5C 149.162661576899 149.536370179332 148.788952974465 0.995001769777008 -0.00722900315444995 0.984252832373031 1 1.19277 1.04527 1.3609 1.19537 GeneID:84787,Genbank:NM_032701.3,HGNC:HGNC:28405,MIM:613198 lysine methyltransferase 5C GO:0000780,GO:0005654,GO:0005720,GO:0005721,GO:0006351,GO:0006355,GO:0018024,GO:0034773,GO:0042799 condensed nuclear chromosome, centromeric region|nucleoplasm|nuclear heterochromatin|pericentric heterochromatin|transcription, DNA-templated|regulation of transcription, DNA-templated|histone-lysine N-methyltransferase activity|histone H4-K20 trimethylation|histone methyltransferase activity (H4-K20 specific) hsa00310 Lysine degradation KNCN 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0133227 0 GeneID:148930,Genbank:NM_001322255.1,HGNC:HGNC:26488,MIM:611455 kinocilin GO:0016021,GO:0016324,GO:0032437,GO:0036064,GO:0043025,GO:0060091 integral component of membrane|apical plasma membrane|cuticular plate|ciliary basal body|neuronal cell body|kinocilium KNDC1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00332952 GeneID:85442,Genbank:XM_017016858.2,HGNC:HGNC:29374,MIM:616237 kinase non-catalytic C-lobe domain containing 1 GO:0001934,GO:0005088,GO:0007264,GO:0021707,GO:0030425,GO:0032045,GO:0043025,GO:0043204,GO:0048814,GO:0050773 positive regulation of protein phosphorylation|Ras guanyl-nucleotide exchange factor activity|small GTPase mediated signal transduction|cerebellar granule cell differentiation|dendrite|guanyl-nucleotide exchange factor complex|neuronal cell body|perikaryon|regulation of dendrite morphogenesis|regulation of dendrite development KNG1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00915848 0 GeneID:3827,Genbank:NM_000893.3,HGNC:HGNC:6383,MIM:612358 kininogen 1 hsa04610 Complement and coagulation cascades KNL1 217.765617099928 205.268205831815 230.263028368042 1.12176665370528 0.165772602369217 0.738059457210989 1 0.783189 0.583776 1.03674 0.538904 GeneID:57082,Genbank:XM_017022432.1,HGNC:HGNC:24054,MIM:609173 kinetochore scaffold 1 KNOP1 565.500733179043 577.10081939763 553.900646960456 0.959798753255298 -0.0591961558419738 0.74371708572588 1 6.20618 6.06206 5.5083 5.98191 GeneID:400506,Genbank:XM_024450278.1,HGNC:HGNC:34404 lysine rich nucleolar protein 1 GO:0003723,GO:0005730 RNA binding|nucleolus KNSTRN 2269.69075884122 2271.83225288906 2267.54926479338 0.99811474280716 -0.00272241823928969 0.991784440204868 1 32.2602 32.6291 32.8963 31.8902 GeneID:90417,Genbank:NM_001142761.1,HGNC:HGNC:30767,MIM:614718 kinetochore localized astrin (SPAG5) binding protein GO:0000070,GO:0000776,GO:0000777,GO:0000922,GO:0005634,GO:0005829,GO:0007051,GO:0007059,GO:0015630,GO:0035371,GO:0051301,GO:0051988,GO:0072686 mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|spindle pole|nucleus|cytosol|spindle organization|chromosome segregation|microtubule cytoskeleton|microtubule plus-end|cell division|regulation of attachment of spindle microtubules to kinetochore|mitotic spindle KNTC1 356.498792005887 392.106820488845 320.89076352293 0.81837587809075 -0.289164473107794 0.389382669721031 1 1.83006 1.4557 1.58844 0.974143 GeneID:9735,Genbank:XM_017020255.2,HGNC:HGNC:17255,MIM:607363 kinetochore associated 1 GO:0000777,GO:0000922,GO:0005634,GO:0005828,GO:0005829,GO:0005886,GO:0006461,GO:0007062,GO:0007093,GO:0007096,GO:0015629,GO:0051301,GO:1990423 condensed chromosome kinetochore|spindle pole|nucleus|kinetochore microtubule|cytosol|plasma membrane|protein complex assembly|sister chromatid cohesion|mitotic cell cycle checkpoint|regulation of exit from mitosis|actin cytoskeleton|cell division|RZZ complex KPNA1 1197.07968079195 1201.37193789615 1192.78742368775 0.992854407583857 -0.0103459187818159 0.974528106439005 1 5.17549 4.9267 5.70186 4.28784 GeneID:3836,Genbank:NM_002264.3,HGNC:HGNC:6394,MIM:600686 karyopherin subunit alpha 1 GO:0000018,GO:0005634,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006309,GO:0006607,GO:0008139,GO:0008565,GO:0019054,GO:0030425,GO:0043657,GO:0075733 regulation of DNA recombination|nucleus|nuclear pore|nucleoplasm|cytoplasm|cytosol|apoptotic DNA fragmentation|NLS-bearing protein import into nucleus|nuclear localization sequence binding|protein transporter activity|modulation by virus of host process|dendrite|host cell|intracellular transport of virus hsa05164 Influenza A KPNA2 9910.49996961444 10729.4442152446 9091.5557239843 0.847346380818762 -0.238976255510936 0.070146137150528 0.92021045003939 153.499 142.701 128.593 125.067 GeneID:3838,Genbank:NM_002266.3,HGNC:HGNC:6395,MIM:600685 karyopherin subunit alpha 2 GO:0000018,GO:0003723,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006259,GO:0006607,GO:0008139,GO:0008565,GO:0016020,GO:0019054,GO:0042826,GO:0043657,GO:0075733 regulation of DNA recombination|RNA binding|nuclear pore|nucleoplasm|cytoplasm|cytosol|DNA metabolic process|NLS-bearing protein import into nucleus|nuclear localization sequence binding|protein transporter activity|membrane|modulation by virus of host process|histone deacetylase binding|host cell|intracellular transport of virus hsa05164 Influenza A KPNA3 670.11484103081 667.954099856773 672.275582204847 1.00646972950537 0.00930378254319777 0.957122342732718 1 6.13313 5.84453 7.1807 5.06831 GeneID:3839,Genbank:NM_002267.3,HGNC:HGNC:6396,MIM:601892 karyopherin subunit alpha 3 GO:0005643,GO:0005654,GO:0005829,GO:0006461,GO:0006607,GO:0008022,GO:0008139,GO:0008565,GO:0019054,GO:0043657,GO:0046718,GO:0075732,GO:0075733 nuclear pore|nucleoplasm|cytosol|protein complex assembly|NLS-bearing protein import into nucleus|protein C-terminus binding|nuclear localization sequence binding|protein transporter activity|modulation by virus of host process|host cell|viral entry into host cell|viral penetration into host nucleus|intracellular transport of virus KPNA4 1729.98156745466 1820.72272506488 1639.24040984444 0.900324023684617 -0.151483778741891 0.541260444232509 1 9.26266 8.11443 9.38875 6.42858 GeneID:3840,Genbank:NM_002268.4,HGNC:HGNC:6397,MIM:602970 karyopherin subunit alpha 4 GO:0005634,GO:0005643,GO:0005654,GO:0005829,GO:0006607,GO:0008139,GO:0008565,GO:0019054,GO:0031965,GO:0042542,GO:0043657,GO:0070062,GO:0075733 nucleus|nuclear pore|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|nuclear localization sequence binding|protein transporter activity|modulation by virus of host process|nuclear membrane|response to hydrogen peroxide|host cell|extracellular exosome|intracellular transport of virus KPNA5 66.1060798556236 67.2730352362507 64.9391244749964 0.96530689074667 -0.0509404174068853 0.912201866796684 1 0.263122 0.25541 0.235035 0.231858 GeneID:3841,Genbank:XM_011535805.2,HGNC:HGNC:6398,MIM:604545 karyopherin subunit alpha 5 GO:0005643,GO:0005654,GO:0005829,GO:0006607,GO:0008139,GO:0008565,GO:0019054,GO:0043657,GO:0075733 nuclear pore|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|nuclear localization sequence binding|protein transporter activity|modulation by virus of host process|host cell|intracellular transport of virus KPNA6 2837.98360423485 3028.97833090122 2646.98887756849 0.873888350591443 -0.194479124471872 0.157420132241237 1 14.5198 14.2904 12.6448 12.7119 GeneID:23633,Genbank:NM_012316.4,HGNC:HGNC:6399,MIM:610563 karyopherin subunit alpha 6 GO:0005643,GO:0005654,GO:0005829,GO:0006607,GO:0008139,GO:0008565,GO:0016020,GO:0045944,GO:0060135 nuclear pore|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|nuclear localization sequence binding|protein transporter activity|membrane|positive regulation of transcription from RNA polymerase II promoter|maternal process involved in female pregnancy KPNA7 1.29177983152393 1.61429302992691 0.969266633120943 0.600427936658332 -0.735936990778882 0.974657200381333 1 0.0097739 0 0.00925193 0.0086092 GeneID:402569,Genbank:XM_017012211.1,HGNC:HGNC:21839,MIM:614107 karyopherin subunit alpha 7 GO:0005643,GO:0005654,GO:0005829,GO:0006607,GO:0008139,GO:0008565,GO:0019054,GO:0043657,GO:0075733 nuclear pore|nucleoplasm|cytosol|NLS-bearing protein import into nucleus|nuclear localization sequence binding|protein transporter activity|modulation by virus of host process|host cell|intracellular transport of virus KPNB1 11673.277701754 11688.1733355955 11658.3820679125 0.997451161372476 -0.00368189111695795 0.987555553331693 1 85.3022 83.6471 93.2307 77.7192 GeneID:3837,Genbank:NM_002265.5,HGNC:HGNC:6400,MIM:602738 karyopherin subunit beta 1 GO:0000060,GO:0003723,GO:0005576,GO:0005635,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006309,GO:0006606,GO:0006607,GO:0006610,GO:0007079,GO:0007080,GO:0008139,GO:0008270,GO:0008536,GO:0008565,GO:0016020,GO:0019054,GO:0019899,GO:0019904,GO:0030953,GO:0031291,GO:0031965,GO:0034399,GO:0035580,GO:0040001,GO:0043312,GO:0043657,GO:0045184,GO:0045540,GO:0051879,GO:0070062,GO:0071782,GO:0075733,GO:0090307,GO:1904813 protein import into nucleus, translocation|RNA binding|extracellular region|nuclear envelope|nuclear pore|nucleoplasm|cytoplasm|cytosol|apoptotic DNA fragmentation|protein import into nucleus|NLS-bearing protein import into nucleus|ribosomal protein import into nucleus|mitotic chromosome movement towards spindle pole|mitotic metaphase plate congression|nuclear localization sequence binding|zinc ion binding|Ran GTPase binding|protein transporter activity|membrane|modulation by virus of host process|enzyme binding|protein domain specific binding|astral microtubule organization|Ran protein signal transduction|nuclear membrane|nuclear periphery|specific granule lumen|establishment of mitotic spindle localization|neutrophil degranulation|host cell|establishment of protein localization|regulation of cholesterol biosynthetic process|Hsp90 protein binding|extracellular exosome|endoplasmic reticulum tubular network|intracellular transport of virus|mitotic spindle assembly|ficolin-1-rich granule lumen hsa03013 RNA transport KPTN 245.398604720713 241.706994366038 249.090215075388 1.03054616077087 0.0434091282868752 0.880139532994728 1 2.4304 3.14749 2.82093 2.86271 GeneID:11133,Genbank:XM_017026228.1,HGNC:HGNC:6404,MIM:615620 kaptin, actin binding protein GO:0005765,GO:0007015,GO:0030027,GO:0032420,GO:0034198,GO:0042149,GO:0051015,GO:0061462,GO:0098871,GO:0140007,GO:1904262 lysosomal membrane|actin filament organization|lamellipodium|stereocilium|cellular response to amino acid starvation|cellular response to glucose starvation|actin filament binding|protein localization to lysosome|postsynaptic actin cytoskeleton|KICSTOR complex|negative regulation of TORC1 signaling KRAS 487.834899869488 527.325258806935 448.34454093204 0.850223905349068 -0.234085271756307 0.375089621568748 1 4.28468 3.94082 4.12527 2.98066 GeneID:3845,Genbank:NM_004985.4,HGNC:HGNC:6407,MIM:190070 KRAS proto-oncogene, GTPase GO:0003924,GO:0005525,GO:0005737,GO:0007165,GO:0008284,GO:0031234 GTPase activity|GTP binding|cytoplasm|signal transduction|positive regulation of cell proliferation|extrinsic component of cytoplasmic side of plasma membrane hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04062,hsa04068,hsa04071,hsa04072,hsa04137,hsa04140,hsa04150,hsa04151,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04371,hsa04540,hsa04550,hsa04625,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04933,hsa04960,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Aldosterone-regulated sodium reabsorption|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer KRBA1 258.764004209756 257.763680771045 259.764327648466 1.00776155458145 0.0111543246345859 0.996004130782079 1 1.82316 1.98773 1.91675 1.98163 GeneID:84626,Genbank:XM_011516636.3,HGNC:HGNC:22228 KRAB-A domain containing 1 KRBA2 108.931267123561 96.2156569162042 121.646877330919 1.26431478233177 0.338355702731999 0.246678356935835 1 0.772666 0.820076 1.05474 0.982051 GeneID:124751,Genbank:XM_017024164.2,HGNC:HGNC:26989 KRAB-A domain containing 2 GO:0003676,GO:0005622,GO:0006355,GO:0015074 nucleic acid binding|intracellular|regulation of transcription, DNA-templated|DNA integration KRBOX4 132.416976385168 131.557615786072 133.276336984263 1.01306439910697 0.018725887188584 0.951570955444572 1 1.6619 1.68395 1.86849 1.59962 GeneID:55634,Genbank:NM_001129899.1,HGNC:HGNC:26007,MIM:300585 KRAB box domain containing 4 GO:0003676,GO:0005622,GO:0006355 nucleic acid binding|intracellular|regulation of transcription, DNA-templated KRCC1 213.837665276853 201.847514673221 225.827815880486 1.11880404495486 0.161957374895431 0.446665182710293 1 3.46219 2.82461 3.53071 3.55547 GeneID:51315,Genbank:NM_001304526.1,HGNC:HGNC:28039 lysine rich coiled-coil 1 GO:0002039,GO:0003723,GO:0005622,GO:0072332 p53 binding|RNA binding|intracellular|intrinsic apoptotic signaling pathway by p53 class mediator KREMEN1 313.529823763441 317.867941421568 309.191706105314 0.972704906076869 -0.0399259004779694 0.844442586010125 1 1.2282 1.2638 1.24781 1.19514 GeneID:83999,Genbank:NM_032045.4,HGNC:HGNC:17550,MIM:609898 kringle containing transmembrane protein 1 GO:0005886,GO:0006915,GO:0007154,GO:0016020,GO:0016021,GO:0016055,GO:0030279,GO:0060173,GO:0060828,GO:0090090 plasma membrane|apoptotic process|cell communication|membrane|integral component of membrane|Wnt signaling pathway|negative regulation of ossification|limb development|regulation of canonical Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway KREMEN2 25.7781153128043 23.936046455902 27.6201841697066 1.15391588249931 0.206538059057695 0.710848224603242 1 0.771707 0.395964 0.4652 0.652781 GeneID:79412,Genbank:NM_172229.2,HGNC:HGNC:18797,MIM:609899 kringle containing transmembrane protein 2 GO:0005886,GO:0007154,GO:0016020,GO:0016021,GO:0016055,GO:0030279,GO:0031901,GO:0060173,GO:0090090 plasma membrane|cell communication|membrane|integral component of membrane|Wnt signaling pathway|negative regulation of ossification|early endosome membrane|limb development|negative regulation of canonical Wnt signaling pathway KRI1 1371.44132424429 1417.51100946785 1325.37163902072 0.934999185310227 -0.0969629869452777 0.498115038885532 1 10.9978 11.3338 9.89591 10.9561 GeneID:65095,Genbank:XM_011528190.2,HGNC:HGNC:25769 KRI1 homolog GO:0000447,GO:0003723,GO:0005730,GO:0030686 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleolus|90S preribosome KRIT1 247.027308122323 245.866679954267 248.187936290379 1.00944111799347 0.013556758855268 0.964801389629469 1 1.41283 1.08303 1.64577 0.911702 GeneID:889,Genbank:NM_001350672.1,HGNC:HGNC:1573,MIM:604214 KRIT1, ankyrin repeat containing GO:0001525,GO:0001937,GO:0005546,GO:0005615,GO:0005737,GO:0005874,GO:0005886,GO:0005911,GO:0007264,GO:0008017,GO:0010596,GO:0016525,GO:0030695,GO:0032092,GO:0032403,GO:0043234,GO:0045454,GO:2000114,GO:2000352 angiogenesis|negative regulation of endothelial cell proliferation|phosphatidylinositol-4,5-bisphosphate binding|extracellular space|cytoplasm|microtubule|plasma membrane|cell-cell junction|small GTPase mediated signal transduction|microtubule binding|negative regulation of endothelial cell migration|negative regulation of angiogenesis|GTPase regulator activity|positive regulation of protein binding|protein complex binding|protein complex|cell redox homeostasis|regulation of establishment of cell polarity|negative regulation of endothelial cell apoptotic process hsa04015 Rap1 signaling pathway KRR1 361.595555476287 388.772373224513 334.41873772806 0.860191620495976 -0.217270017461789 0.292215109129356 1 4.28702 3.81316 4.02341 3.0967 GeneID:11103,Genbank:NM_007043.6,HGNC:HGNC:5176,MIM:612817 KRR1, small subunit processome component homolog GO:0000462,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0016020,GO:0032040,GO:0045171 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|membrane|small-subunit processome|intercellular bridge KRT10 949.094724635971 964.827440235037 933.362009036905 0.967387503831289 -0.0478341929078743 0.750927799255605 1 6.42081 7.08852 6.68143 7.32588 GeneID:3858,Genbank:XM_005257343.3,HGNC:HGNC:6413,MIM:148080 keratin 10 hsa04915,hsa05150 Estrogen signaling pathway|Staphylococcus aureus infection KRT13 43.2069304262941 62.1900247730453 24.223836079543 0.389513208395476 -1.36025584397254 0.00186819683677835 0.153441233527396 1.05498 1.22175 0.314118 0.646101 GeneID:3860,Genbank:NM_002274.3,HGNC:HGNC:6415,MIM:148065 keratin 13 hsa04915 Estrogen signaling pathway KRT14 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0259409 0 0 0 GeneID:3861,Genbank:NM_000526.4,HGNC:HGNC:6416,MIM:148066 keratin 14 hsa04915 Estrogen signaling pathway KRT15 280.244258339443 301.292774650134 259.195742028753 0.860278651984718 -0.217124057488723 0.660359035528946 1 1.68533 2.14279 1.20439 2.63219 GeneID:3866,Genbank:XM_011524784.3,HGNC:HGNC:6421,MIM:148030 keratin 15 GO:0005200,GO:0005634,GO:0005829,GO:0005882,GO:0008544,GO:0031424,GO:0070062,GO:0070268,GO:0097110 structural constituent of cytoskeleton|nucleus|cytosol|intermediate filament|epidermis development|keratinization|extracellular exosome|cornification|scaffold protein binding hsa04915 Estrogen signaling pathway KRT16 6.11977869911325 6.90902590208801 5.33053149613849 0.771531554763389 -0.374202932297824 0.827518560115089 1 0.0266885 0.163986 0.0498225 0.0694333 GeneID:3868,Genbank:NM_005557.3,HGNC:HGNC:6423,MIM:148067 keratin 16 hsa04915 Estrogen signaling pathway KRT17 3.10308228774458 5.23689794236822 0.969266633120943 0.185084117312896 -2.43374699685365 0.234845579374409 1 0.139191 0.0729572 0 0.0240254 GeneID:3872,Genbank:NM_000422.2,HGNC:HGNC:6427,MIM:148069 keratin 17 hsa04915 Estrogen signaling pathway KRT18 822.458831951444 858.464362701783 786.453301201104 0.916116422964788 -0.126397142677731 0.544867213618415 1 18.3222 18.1289 14.7211 18.7086 GeneID:3875,Genbank:NM_199187.1,HGNC:HGNC:6430,MIM:148070 keratin 18 hsa04915,hsa05130 Estrogen signaling pathway|Pathogenic Escherichia coli infection KRT19 2.83153189973833 4.20872886376855 1.45433493570811 0.34555206162791 -1.53302500831413 0.487353903625154 1 0.145189 0.0313474 0.0672143 0 GeneID:3880,Genbank:NM_002276.4,HGNC:HGNC:6436,MIM:148020 keratin 19 GO:0005200,GO:0005829,GO:0005882,GO:0005886,GO:0007219,GO:0008307,GO:0016010,GO:0016032,GO:0016327,GO:0030018,GO:0031424,GO:0032403,GO:0042383,GO:0043034,GO:0043627,GO:0045214,GO:0060706,GO:0070062,GO:0070268,GO:0071944,GO:1990357 structural constituent of cytoskeleton|cytosol|intermediate filament|plasma membrane|Notch signaling pathway|structural constituent of muscle|dystrophin-associated glycoprotein complex|viral process|apicolateral plasma membrane|Z disc|keratinization|protein complex binding|sarcolemma|costamere|response to estrogen|sarcomere organization|cell differentiation involved in embryonic placenta development|extracellular exosome|cornification|cell periphery|terminal web hsa04915 Estrogen signaling pathway KRT222 1.73175839513795 2.00831188251439 1.45520490776151 0.724591095850912 -0.464761017567955 0.96907092558689 1 0.0219046 0.0213079 0.0633524 0 GeneID:125113,Genbank:NM_152349.2,HGNC:HGNC:28695 keratin 222 GO:0005198,GO:0005882 structural molecule activity|intermediate filament KRT23 5.74346492641796 5.18887166768327 6.29805818515264 1.21376256506351 0.27948623073076 0.881662121798063 1 0.0776659 0.0238911 0.0367933 0.0799889 GeneID:25984,Genbank:NM_015515.4,HGNC:HGNC:6438,MIM:606194 keratin 23 GO:0005198,GO:0005829,GO:0005882,GO:0031424,GO:0070268 structural molecule activity|cytosol|intermediate filament|keratinization|cornification hsa04915 Estrogen signaling pathway KRT28 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0434965 GeneID:162605,Genbank:NM_181535.3,HGNC:HGNC:30842,MIM:616677 keratin 28 GO:0005198,GO:0005829,GO:0005882,GO:0031424,GO:0070062,GO:0070268 structural molecule activity|cytosol|intermediate filament|keratinization|extracellular exosome|cornification hsa04915 Estrogen signaling pathway KRT34 1.02523254288787 1.56626675524197 0.484198330533773 0.309141676482158 -1.69365993276169 0.789571303159055 1 0 0 0 0.0183424 GeneID:3885,Genbank:XM_011524793.2,HGNC:HGNC:6452,MIM:602763 keratin 34 GO:0005198,GO:0005615,GO:0005829,GO:0005882,GO:0008544,GO:0031424,GO:0070062,GO:0070268 structural molecule activity|extracellular space|cytosol|intermediate filament|epidermis development|keratinization|extracellular exosome|cornification hsa04915 Estrogen signaling pathway KRT4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0171365 0 GeneID:3851,Genbank:NM_002272.3,HGNC:HGNC:6441,MIM:123940 keratin 4 KRT5 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0207213 0 0 0 GeneID:3852,Genbank:NM_000424.3,HGNC:HGNC:6442,MIM:148040 keratin 5 KRT7 78.0132046172511 102.730663965705 53.2957452687975 0.51879101342701 -0.946774605653527 0.00419341212892283 0.253440334554068 0.696641 0.986095 0.380588 0.530585 GeneID:3855,Genbank:NM_005556.3,HGNC:HGNC:6445,MIM:148059 keratin 7 GO:0005198,GO:0005634,GO:0005737,GO:0005829,GO:0005882,GO:0016032,GO:0031424,GO:0045095,GO:0070062,GO:0070268 structural molecule activity|nucleus|cytoplasm|cytosol|intermediate filament|viral process|keratinization|keratin filament|extracellular exosome|cornification KRT75 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0201955 0 0.0189132 0 GeneID:9119,Genbank:NM_004693.2,HGNC:HGNC:24431,MIM:609025 keratin 75 GO:0002244,GO:0005198,GO:0005829,GO:0005882,GO:0031424,GO:0045095,GO:0070062,GO:0070268 hematopoietic progenitor cell differentiation|structural molecule activity|cytosol|intermediate filament|keratinization|keratin filament|extracellular exosome|cornification KRT8 86.932344815805 84.2236205509107 89.6410690806994 1.06432219957243 0.0899349603869915 0.82215466527357 1 0.830379 0.582151 0.556336 0.831107 GeneID:3856,Genbank:NM_001256293.1,HGNC:HGNC:6446,MIM:148060 keratin 8 KRT80 3946.19609437171 4711.4826816582 3180.90950708521 0.67513980672549 -0.566741811117333 2.27503141128525e-05 0.00847369839142897 35.9113 38.3996 24.3853 26.9465 GeneID:144501,Genbank:NM_182507.2,HGNC:HGNC:27056,MIM:611161 keratin 80 GO:0005198,GO:0005737,GO:0005829,GO:0005882,GO:0031424,GO:0045095,GO:0045111,GO:0070268 structural molecule activity|cytoplasm|cytosol|intermediate filament|keratinization|keratin filament|intermediate filament cytoskeleton|cornification KRT81 1532.38918341734 2178.06121233095 886.717154503731 0.407113055172021 -1.29649860878174 6.5907370143475e-08 6.20924964834056e-05 43.976 49.49 16.0255 22.6954 GeneID:3887,Genbank:NM_002281.3,HGNC:HGNC:6458,MIM:602153 keratin 81 KRT83 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0439227 0 0 GeneID:3889,Genbank:NM_002282.3,HGNC:HGNC:6460,MIM:602765 keratin 83 GO:0005198,GO:0005615,GO:0005829,GO:0007568,GO:0008544,GO:0031424,GO:0042633,GO:0045095,GO:0070268 structural molecule activity|extracellular space|cytosol|aging|epidermis development|keratinization|hair cycle|keratin filament|cornification KRT85 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.033521 0.0443437 0.015636 0 GeneID:3891,Genbank:NM_002283.3,HGNC:HGNC:6462,MIM:602767 keratin 85 GO:0005198,GO:0005615,GO:0005829,GO:0008544,GO:0031424,GO:0045095,GO:0070268 structural molecule activity|extracellular space|cytosol|epidermis development|keratinization|keratin filament|cornification KRT86 43.5201131659136 66.2066485380741 20.8335777937532 0.314675010044833 -1.6680654835085 0.00015966161280727 0.0305777940498961 0.197519 0.325044 0.0694721 0.0938991 GeneID:3892,Genbank:XM_005268866.4,HGNC:HGNC:6463,MIM:601928 keratin 86 KRT9 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.0136639 0.014146 0 GeneID:3857,Genbank:NM_000226.3,HGNC:HGNC:6447,MIM:607606 keratin 9 hsa04915 Estrogen signaling pathway KRTAP2-3 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.171142 0 0 GeneID:730755,Genbank:NM_001165252.1,HGNC:HGNC:18906 keratin associated protein 2-3 GO:0005829,GO:0031424,GO:0045095 cytosol|keratinization|keratin filament KRTAP5-2 3.75190228612093 4.11267631439867 3.3911282578432 0.824555106846291 -0.278312179493699 0.953534838059336 1 0.229777 0.266677 0.142087 0.265675 GeneID:440021,Genbank:NM_001004325.1,HGNC:HGNC:23597 keratin associated protein 5-2 KRTCAP2 1056.54685420582 1044.09352883744 1069.00017957421 1.02385480806926 0.0340111425547386 0.87462668215807 1 131.964 149.407 136.065 155.148 GeneID:200185,Genbank:NM_173852.3,HGNC:HGNC:28942 keratinocyte associated protein 2 GO:0008250,GO:0016021,GO:0042543 oligosaccharyltransferase complex|integral component of membrane|protein N-linked glycosylation via arginine KRTCAP3 2.24747451206948 3.52655236307142 0.968396661067546 0.274601526184097 -1.86458845114995 0.453275686177039 1 0.0622006 0 0 0.0547023 GeneID:200634,Genbank:NM_001168364.1,HGNC:HGNC:28943 keratinocyte associated protein 3 GO:0016021 integral component of membrane KSR1 249.976340523038 254.697773844608 245.254907201467 0.962925209354593 -0.0545043469571942 0.810529147481303 1 0.835188 0.808474 0.94 0.701872 GeneID:8844,Genbank:XM_017025279.1,HGNC:HGNC:6465,MIM:601132 kinase suppressor of ras 1 hsa04014,hsa04625,hsa05152 Ras signaling pathway|C-type lectin receptor signaling pathway|Tuberculosis KSR2 28.5243480411703 23.5998625331074 33.4488335492332 1.41733171124658 0.503177445034609 0.361104728062075 1 0.0398065 0.0365464 0.0716074 0.0405056 GeneID:283455,Genbank:NM_173598.4,HGNC:HGNC:18610,MIM:610737 kinase suppressor of ras 2 GO:0004672,GO:0004674,GO:0004871,GO:0005524,GO:0005829,GO:0005886,GO:0006468,GO:0019722,GO:0043410,GO:0046872 protein kinase activity|protein serine/threonine kinase activity|signal transducer activity|ATP binding|cytosol|plasma membrane|protein phosphorylation|calcium-mediated signaling|positive regulation of MAPK cascade|metal ion binding hsa04014 Ras signaling pathway KTI12 396.097936876413 404.022421614984 388.173452137843 0.960772054645412 -0.0577339059699666 0.773642875102705 1 13.211 11.8003 11.9922 12.3736 GeneID:112970,Genbank:NM_138417.2,HGNC:HGNC:25160 KTI12 chromatin associated homolog GO:0005524 ATP binding KTN1 719.679465453467 688.006775715738 751.352155191197 1.09207086574047 0.127066477443769 0.763278644192162 1 2.34702 1.72213 2.96988 1.64525 GeneID:3895,Genbank:NM_001271014.1,HGNC:HGNC:6467,MIM:600381 kinectin 1 GO:0003723,GO:0005783,GO:0005788,GO:0005789,GO:0005887,GO:0007018,GO:0016020,GO:0016021,GO:0019894,GO:0043687,GO:0044267,GO:0045296 RNA binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral component of plasma membrane|microtubule-based movement|membrane|integral component of membrane|kinesin binding|post-translational protein modification|cellular protein metabolic process|cadherin binding KXD1 2921.68841073388 2989.09451024735 2854.28231122042 0.954898649552643 -0.066580477495108 0.610226871996972 1 28.5514 30.6679 27.4073 30.6602 GeneID:79036,Genbank:NM_001171949.1,HGNC:HGNC:28420,MIM:615178 KxDL motif containing 1 GO:0005765,GO:0016192,GO:0031083,GO:0032418,GO:0099078 lysosomal membrane|vesicle-mediated transport|BLOC-1 complex|lysosome localization|BORC complex KYAT1 218.349645716028 214.282613166642 222.416678265414 1.03795951980689 0.0537501800034651 0.876789774057941 1 1.4846 1.82442 1.51157 2.09597 GeneID:883,Genbank:XM_011519167.3,HGNC:HGNC:1564,MIM:600547 kynurenine aminotransferase 1 GO:0005654,GO:0005829,GO:0006559,GO:0006569,GO:0006575,GO:0008483,GO:0008652,GO:0016212,GO:0030170,GO:0042803,GO:0047312,GO:0047316,GO:0047804,GO:0047945,GO:0070189,GO:0097053 nucleoplasm|cytosol|L-phenylalanine catabolic process|tryptophan catabolic process|cellular modified amino acid metabolic process|transaminase activity|cellular amino acid biosynthetic process|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding|protein homodimerization activity|L-phenylalanine:pyruvate aminotransferase activity|glutamine-phenylpyruvate transaminase activity|cysteine-S-conjugate beta-lyase activity|L-glutamine:pyruvate aminotransferase activity|kynurenine metabolic process|L-kynurenine catabolic process hsa00270,hsa00380,hsa00450,hsa05204 Cysteine and methionine metabolism|Tryptophan metabolism|Selenocompound metabolism|Chemical carcinogenesis KYAT3 419.799496287656 423.787956826694 415.811035748618 0.981177093521468 -0.0274145416367066 0.911801186011013 1 6.86524 6.69268 7.04782 6.36055 GeneID:56267,Genbank:NM_001349447.1,HGNC:HGNC:33238,MIM:610656 kynurenine aminotransferase 3 GO:0003723,GO:0005739,GO:0006103,GO:0006520,GO:0009058,GO:0016212,GO:0030170,GO:0042803,GO:0047315,GO:0047804,GO:0070189 RNA binding|mitochondrion|2-oxoglutarate metabolic process|cellular amino acid metabolic process|biosynthetic process|kynurenine-oxoglutarate transaminase activity|pyridoxal phosphate binding|protein homodimerization activity|kynurenine-glyoxylate transaminase activity|cysteine-S-conjugate beta-lyase activity|kynurenine metabolic process hsa00270,hsa00380,hsa00450,hsa05204 Cysteine and methionine metabolism|Tryptophan metabolism|Selenocompound metabolism|Chemical carcinogenesis KYNU 3.55826438156569 4.20872886376855 2.90779989936283 0.690897416651152 -0.533456577436287 0.844116364888654 1 0.042092 0.0268791 0.0405417 0.025094 GeneID:8942,Genbank:NM_001199241.1,HGNC:HGNC:6469,MIM:605197 kynureninase GO:0005654,GO:0005739,GO:0005829,GO:0006569,GO:0009435,GO:0019441,GO:0019442,GO:0019805,GO:0030170,GO:0030429,GO:0034341,GO:0034516,GO:0042803,GO:0043420,GO:0097053 nucleoplasm|mitochondrion|cytosol|tryptophan catabolic process|NAD biosynthetic process|tryptophan catabolic process to kynurenine|tryptophan catabolic process to acetyl-CoA|quinolinate biosynthetic process|pyridoxal phosphate binding|kynureninase activity|response to interferon-gamma|response to vitamin B6|protein homodimerization activity|anthranilate metabolic process|L-kynurenine catabolic process hsa00380 Tryptophan metabolism L1CAM 329.33721523582 335.894722089512 322.779708382128 0.960954987247793 -0.0574592405743966 0.76370579453735 1 1.86028 1.86373 1.94786 1.75224 GeneID:3897,Genbank:NM_001278116.1,HGNC:HGNC:6470,MIM:308840 L1 cell adhesion molecule hsa04360,hsa04514 Axon guidance|Cell adhesion molecules (CAMs) L2HGDH 307.215295808585 333.818766622097 280.611824995074 0.840611292871809 -0.250489256930998 0.211071509617018 1 1.57796 1.52066 1.41445 1.19085 GeneID:79944,Genbank:NM_024884.2,HGNC:HGNC:20499,MIM:609584 L-2-hydroxyglutarate dehydrogenase GO:0005739,GO:0005743,GO:0006103,GO:0016021,GO:0031305,GO:0044267,GO:0047545 mitochondrion|mitochondrial inner membrane|2-oxoglutarate metabolic process|integral component of membrane|integral component of mitochondrial inner membrane|cellular protein metabolic process|2-hydroxyglutarate dehydrogenase activity hsa00650 Butanoate metabolism L3HYPDH 771.716967831757 816.031081486195 727.402854177319 0.891391113255806 -0.165869516846474 0.293136972777191 1 5.2343 5.6474 4.81282 4.73064 GeneID:112849,Genbank:XM_024449462.1,HGNC:HGNC:20488,MIM:614811 trans-L-3-hydroxyproline dehydratase GO:0016836,GO:0050346 hydro-lyase activity|trans-L-3-hydroxyproline dehydratase activity hsa00330 Arginine and proline metabolism L3MBTL1 25.9650326747362 26.242324641634 25.6877407078385 0.978866813768639 -0.0308155171695594 1 1 0.247188 0.157863 0.15451 0.0926851 GeneID:26013,Genbank:NM_032107.4,HGNC:HGNC:15905,MIM:608802 L3MBTL1, histone methyl-lysine binding protein GO:0000785,GO:0000793,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0005886,GO:0006325,GO:0006351,GO:0007088,GO:0008270,GO:0016569,GO:0030097,GO:0031491,GO:0031493,GO:0032093,GO:0035064,GO:0042393,GO:0042802,GO:0045652,GO:0045892,GO:0051726,GO:1901796 chromatin|condensed chromosome|chromatin binding|DNA binding transcription factor activity|nucleus|nucleoplasm|plasma membrane|chromatin organization|transcription, DNA-templated|regulation of mitotic nuclear division|zinc ion binding|covalent chromatin modification|hemopoiesis|nucleosome binding|nucleosomal histone binding|SAM domain binding|methylated histone binding|histone binding|identical protein binding|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|regulation of cell cycle|regulation of signal transduction by p53 class mediator L3MBTL2 936.158484822448 985.938728138781 886.378241506114 0.899019600517556 -0.153575525019475 0.313098726126476 1 7.59557 7.8954 7.21739 7.06856 GeneID:83746,Genbank:XM_011530420.2,HGNC:HGNC:18594,MIM:611865 L3MBTL2, polycomb repressive complex 1 subunit GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0008270,GO:0016569,GO:0016925,GO:0035064,GO:0042393,GO:0070317 nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|covalent chromatin modification|protein sumoylation|methylated histone binding|histone binding|negative regulation of G0 to G1 transition L3MBTL3 120.711224711219 130.423585502995 110.998863919443 0.851064349223046 -0.232659876260267 0.450551036115228 1 0.926616 0.712456 0.87534 0.549081 GeneID:84456,Genbank:NM_032438.3,HGNC:HGNC:23035 L3MBTL3, histone methyl-lysine binding protein GO:0003700,GO:0005634,GO:0005730,GO:0006351,GO:0008270,GO:0016569,GO:0030225,GO:0030851,GO:0043249 DNA binding transcription factor activity|nucleus|nucleolus|transcription, DNA-templated|zinc ion binding|covalent chromatin modification|macrophage differentiation|granulocyte differentiation|erythrocyte maturation L3MBTL4 1.24125200715389 1.02816907859967 1.45433493570811 1.4144900541931 0.500282032643154 1 1 0.00289604 0.00275586 0.0055638 0 GeneID:91133,Genbank:XM_017026075.1,HGNC:HGNC:26677,MIM:617135 L3MBTL4, histone methyl-lysine binding protein GO:0003700,GO:0005634,GO:0006351,GO:0008270,GO:0016569 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|zinc ion binding|covalent chromatin modification LACTB 824.826148427876 876.162734100332 773.48956275542 0.882814952806297 -0.179817029206403 0.270788823211038 1 9.27601 8.54912 8.95226 7.63888 GeneID:114294,Genbank:NM_032857.4,HGNC:HGNC:16468,MIM:608440 lactamase beta GO:0005739,GO:0005829,GO:0006508,GO:0006629,GO:0008233,GO:0019216,GO:0042802 mitochondrion|cytosol|proteolysis|lipid metabolic process|peptidase activity|regulation of lipid metabolic process|identical protein binding LACTB2 334.431594832414 377.616400839079 291.246788825749 0.771276851796125 -0.374679282711196 0.057278885898275 0.867087558172753 9.45399 8.85723 6.83077 7.56128 GeneID:51110,Genbank:NM_016027.2,HGNC:HGNC:18512 lactamase beta 2 GO:0003727,GO:0004521,GO:0005759,GO:0008270,GO:0090502 single-stranded RNA binding|endoribonuclease activity|mitochondrial matrix|zinc ion binding|RNA phosphodiester bond hydrolysis, endonucleolytic LAG3 5.56287812278998 7.24520982488261 3.88054642069736 0.53560166157924 -0.900767658593302 0.520102856252334 1 0.181836 0.103938 0.194666 0 GeneID:3902,Genbank:XM_011520956.1,HGNC:HGNC:6476,MIM:153337 lymphocyte activating 3 GO:0003823,GO:0004888,GO:0005886,GO:0007166,GO:0009897,GO:0016021,GO:0019886,GO:0042289,GO:0045085,GO:0045954,GO:0050868 antigen binding|transmembrane signaling receptor activity|plasma membrane|cell surface receptor signaling pathway|external side of plasma membrane|integral component of membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|MHC class II protein binding|negative regulation of interleukin-2 biosynthetic process|positive regulation of natural killer cell mediated cytotoxicity|negative regulation of T cell activation LAGE3 726.637452309385 720.133008183425 733.141896435345 1.01806456321831 0.0258290565818782 0.935472130097483 1 52.1651 52.3503 47.8157 60.2754 GeneID:8270,Genbank:NM_006014.4,HGNC:HGNC:26058,MIM:300060 L antigen family member 3 GO:0000408,GO:0005654,GO:0008033,GO:0016604 EKC/KEOPS complex|nucleoplasm|tRNA processing|nuclear body LAIR1 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0118234 0 0.0110908 0 GeneID:3903,Genbank:NM_001289027.2,HGNC:HGNC:6477,MIM:602992 leukocyte associated immunoglobulin like receptor 1 GO:0002250,GO:0005886,GO:0016021,GO:0035579,GO:0043312,GO:0050776,GO:0070062,GO:0070821 adaptive immune response|plasma membrane|integral component of membrane|specific granule membrane|neutrophil degranulation|regulation of immune response|extracellular exosome|tertiary granule membrane LAMA1 54.5863761967564 41.3188682427264 67.8538841507864 1.64220093716461 0.715630663848288 0.0631735738681754 0.894697583479674 0.139558 0.123673 0.256384 0.187714 GeneID:284217,Genbank:NM_005559.3,HGNC:HGNC:6481,MIM:150320 laminin subunit alpha 1 GO:0005102,GO:0005201,GO:0005576,GO:0005578,GO:0005604,GO:0005606,GO:0005608,GO:0005615,GO:0007155,GO:0007166,GO:0008022,GO:0016020,GO:0030155,GO:0030198,GO:0030334,GO:0031012,GO:0045995 receptor binding|extracellular matrix structural constituent|extracellular region|proteinaceous extracellular matrix|basement membrane|laminin-1 complex|laminin-3 complex|extracellular space|cell adhesion|cell surface receptor signaling pathway|protein C-terminus binding|membrane|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|extracellular matrix|regulation of embryonic development hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMA2 80.7231131085586 72.7500645520437 88.6961616650735 1.2191901438331 0.285923144967673 0.373418803175885 1 0.150844 0.118936 0.221197 0.161913 GeneID:3908,Genbank:XM_005266981.3,HGNC:HGNC:6482,MIM:156225 laminin subunit alpha 2 GO:0005102,GO:0005198,GO:0005576,GO:0005604,GO:0005605,GO:0007155,GO:0007411,GO:0007517,GO:0014037,GO:0030155,GO:0030198,GO:0030334,GO:0031012,GO:0032224,GO:0042383,GO:0043197,GO:0045995,GO:0070062 receptor binding|structural molecule activity|extracellular region|basement membrane|basal lamina|cell adhesion|axon guidance|muscle organ development|Schwann cell differentiation|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|extracellular matrix|positive regulation of synaptic transmission, cholinergic|sarcolemma|dendritic spine|regulation of embryonic development|extracellular exosome hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222,hsa05410,hsa05412,hsa05414,hsa05416 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Viral myocarditis LAMA3 2.70059004223219 2.00831188251439 3.39286820195 1.68941299978874 0.756522057512588 0.793428004942648 1 0.00341357 0.0093968 0.0129647 0.00904425 GeneID:3909,Genbank:XM_011525978.2,HGNC:HGNC:6483,MIM:600805 laminin subunit alpha 3 GO:0005102,GO:0005198,GO:0005576,GO:0005604,GO:0005610,GO:0005783,GO:0007155,GO:0008544,GO:0022617,GO:0030155,GO:0030198,GO:0030334,GO:0031012,GO:0031581,GO:0035987,GO:0045995,GO:0070062 receptor binding|structural molecule activity|extracellular region|basement membrane|laminin-5 complex|endoplasmic reticulum|cell adhesion|epidermis development|extracellular matrix disassembly|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|extracellular matrix|hemidesmosome assembly|endodermal cell differentiation|regulation of embryonic development|extracellular exosome hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMA4 2463.33784190734 2220.12481565501 2706.55086815967 1.21909851602697 0.28581471565514 0.233487849003069 1 8.39719 8.20892 12.0698 8.21049 GeneID:3910,Genbank:NM_002290.4,HGNC:HGNC:6484,MIM:600133 laminin subunit alpha 4 GO:0005102,GO:0005201,GO:0005576,GO:0005604,GO:0005605,GO:0007155,GO:0030155,GO:0030198,GO:0030334,GO:0031012,GO:0045995,GO:0070062 receptor binding|extracellular matrix structural constituent|extracellular region|basement membrane|basal lamina|cell adhesion|regulation of cell adhesion|extracellular matrix organization|regulation of cell migration|extracellular matrix|regulation of embryonic development|extracellular exosome hsa04151,hsa04510,hsa04512,hsa05143,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|African trypanosomiasis|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMA5 5587.05871983085 6285.69207823858 4888.42536142312 0.777706782415755 -0.362701774239686 0.00545949306793487 0.289494854466933 22.1728 23.4656 18.6859 17.627 GeneID:3911,Genbank:XM_011528819.2,HGNC:HGNC:6485,MIM:601033 laminin subunit alpha 5 GO:0001525,GO:0001658,GO:0001738,GO:0001755,GO:0001942,GO:0005178,GO:0005576,GO:0005604,GO:0005605,GO:0005610,GO:0005615,GO:0005634,GO:0007010,GO:0007229,GO:0007517,GO:0008037,GO:0008283,GO:0016331,GO:0016477,GO:0019221,GO:0030154,GO:0030155,GO:0030198,GO:0030324,GO:0030334,GO:0031012,GO:0034446,GO:0042127,GO:0042475,GO:0043083,GO:0043259,GO:0043260,GO:0045446,GO:0045995,GO:0048041,GO:0060271,GO:0060445,GO:0070062,GO:0072659 angiogenesis|branching involved in ureteric bud morphogenesis|morphogenesis of a polarized epithelium|neural crest cell migration|hair follicle development|integrin binding|extracellular region|basement membrane|basal lamina|laminin-5 complex|extracellular space|nucleus|cytoskeleton organization|integrin-mediated signaling pathway|muscle organ development|cell recognition|cell proliferation|morphogenesis of embryonic epithelium|cell migration|cytokine-mediated signaling pathway|cell differentiation|regulation of cell adhesion|extracellular matrix organization|lung development|regulation of cell migration|extracellular matrix|substrate adhesion-dependent cell spreading|regulation of cell proliferation|odontogenesis of dentin-containing tooth|synaptic cleft|laminin-10 complex|laminin-11 complex|endothelial cell differentiation|regulation of embryonic development|focal adhesion assembly|cilium assembly|branching involved in salivary gland morphogenesis|extracellular exosome|protein localization to plasma membrane hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMB1 4120.02152488786 4275.90830887004 3964.13474090567 0.927086002448269 -0.109224916176327 0.417453279262483 1 20.3007 19.7215 21.5561 16.5468 GeneID:3912,Genbank:XM_017012201.1,HGNC:HGNC:6486,MIM:150240 laminin subunit beta 1 GO:0005198,GO:0005201,GO:0005576,GO:0005604,GO:0005606,GO:0005607,GO:0005615,GO:0005788,GO:0007155,GO:0021812,GO:0030198,GO:0030335,GO:0031012,GO:0031175,GO:0034446,GO:0035987,GO:0042476,GO:0043257,GO:0043259,GO:0043687,GO:0044267,GO:0048471,GO:0050679,GO:0070062 structural molecule activity|extracellular matrix structural constituent|extracellular region|basement membrane|laminin-1 complex|laminin-2 complex|extracellular space|endoplasmic reticulum lumen|cell adhesion|neuronal-glial interaction involved in cerebral cortex radial glia guided migration|extracellular matrix organization|positive regulation of cell migration|extracellular matrix|neuron projection development|substrate adhesion-dependent cell spreading|endodermal cell differentiation|odontogenesis|laminin-8 complex|laminin-10 complex|post-translational protein modification|cellular protein metabolic process|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|extracellular exosome hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMB2 5200.40877015784 4601.8910180651 5798.92652225059 1.26011817739413 0.333559040031146 0.0128067437085421 0.46405612496835 30.2605 31.1739 39.6194 39.395 GeneID:3913,Genbank:NM_002292.3,HGNC:HGNC:6487,MIM:150325 laminin subunit beta 2 GO:0005178,GO:0005198,GO:0005576,GO:0005604,GO:0005605,GO:0005608,GO:0005788,GO:0007155,GO:0007411,GO:0007528,GO:0007601,GO:0014002,GO:0014044,GO:0030198,GO:0031012,GO:0043083,GO:0043260,GO:0043687,GO:0044267,GO:0048677,GO:0060041,GO:0070062,GO:0072249,GO:0072274 integrin binding|structural molecule activity|extracellular region|basement membrane|basal lamina|laminin-3 complex|endoplasmic reticulum lumen|cell adhesion|axon guidance|neuromuscular junction development|visual perception|astrocyte development|Schwann cell development|extracellular matrix organization|extracellular matrix|synaptic cleft|laminin-11 complex|post-translational protein modification|cellular protein metabolic process|axon extension involved in regeneration|retina development in camera-type eye|extracellular exosome|metanephric glomerular visceral epithelial cell development|metanephric glomerular basement membrane development hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMB3 787.608933527386 792.085226375185 783.132640679586 0.988697446439483 -0.0163989887670664 0.913334296158232 1 6.40898 6.75253 6.44811 6.77289 GeneID:3914,Genbank:NM_000228.2,HGNC:HGNC:6490,MIM:150310 laminin subunit beta 3 GO:0005198,GO:0005576,GO:0005610,GO:0007155,GO:0008544,GO:0022617,GO:0030198,GO:0031581,GO:0032403,GO:0035987,GO:0050873 structural molecule activity|extracellular region|laminin-5 complex|cell adhesion|epidermis development|extracellular matrix disassembly|extracellular matrix organization|hemidesmosome assembly|protein complex binding|endodermal cell differentiation|brown fat cell differentiation hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMB4 5.17289362570308 6.46698077481559 3.87880647659057 0.599786300849359 -0.737479523534984 0.643162468201879 1 0.00867438 0.0449393 0.0207526 0.00386074 GeneID:22798,Genbank:XM_011515975.1,HGNC:HGNC:6491,MIM:616380 laminin subunit beta 4 GO:0005604,GO:0007155 basement membrane|cell adhesion hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMC1 8992.69628310413 8766.12865687205 9219.26390933621 1.05169160415059 0.0727117137651218 0.57693139685737 1 40.7894 40.8585 48.2862 38.9266 GeneID:3915,Genbank:NM_002293.3,HGNC:HGNC:6492,MIM:150290 laminin subunit gamma 1 GO:0005201,GO:0005576,GO:0005604,GO:0005606,GO:0005615,GO:0005788,GO:0006461,GO:0007155,GO:0007492,GO:0016477,GO:0022617,GO:0030198,GO:0031012,GO:0031581,GO:0034446,GO:0043259,GO:0043260,GO:0043687,GO:0044267,GO:0050679,GO:0070062 extracellular matrix structural constituent|extracellular region|basement membrane|laminin-1 complex|extracellular space|endoplasmic reticulum lumen|protein complex assembly|cell adhesion|endoderm development|cell migration|extracellular matrix disassembly|extracellular matrix organization|extracellular matrix|hemidesmosome assembly|substrate adhesion-dependent cell spreading|laminin-10 complex|laminin-11 complex|post-translational protein modification|cellular protein metabolic process|positive regulation of epithelial cell proliferation|extracellular exosome hsa04151,hsa04510,hsa04512,hsa05020,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Prion diseases|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMC2 21.7021018662875 21.6013593057009 21.8028444268741 1.00932742788645 0.0133942636013076 1 1 0.0466742 0.144592 0.0498341 0.123628 GeneID:3918,Genbank:NM_005562.2,HGNC:HGNC:6493,MIM:150292 laminin subunit gamma 2 GO:0005576,GO:0005607,GO:0005615,GO:0005938,GO:0007155,GO:0008201,GO:0008284,GO:0008544,GO:0016020,GO:0022617,GO:0030198,GO:0030335,GO:0031581,GO:0048471,GO:0048731,GO:0070831 extracellular region|laminin-2 complex|extracellular space|cell cortex|cell adhesion|heparin binding|positive regulation of cell proliferation|epidermis development|membrane|extracellular matrix disassembly|extracellular matrix organization|positive regulation of cell migration|hemidesmosome assembly|perinuclear region of cytoplasm|system development|basement membrane assembly hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMC3 16.5223457158472 14.1444270718627 18.9002643598317 1.33623399970931 0.418172672976085 0.545950460526564 1 0.131487 0.0461669 0.0996708 0.093348 GeneID:10319,Genbank:NM_006059.3,HGNC:HGNC:6494,MIM:604349 laminin subunit gamma 3 GO:0000904,GO:0005198,GO:0005576,GO:0005578,GO:0005604,GO:0007155,GO:0007601,GO:0014002,GO:0016020,GO:0030198,GO:0060041 cell morphogenesis involved in differentiation|structural molecule activity|extracellular region|proteinaceous extracellular matrix|basement membrane|cell adhesion|visual perception|astrocyte development|membrane|extracellular matrix organization|retina development in camera-type eye hsa04151,hsa04510,hsa04512,hsa05145,hsa05146,hsa05165,hsa05200,hsa05222 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Toxoplasmosis|Amoebiasis|Human papillomavirus infection|Pathways in cancer|Small cell lung cancer LAMP1 9056.20716613168 8520.45815001995 9591.95618224341 1.12575591750556 0.170894061187183 0.194623658514393 1 153.881 157.55 176.528 179.728 GeneID:3916,Genbank:NM_005561.3,HGNC:HGNC:6499,MIM:153330 lysosomal associated membrane protein 1 GO:0001618,GO:0005737,GO:0005764,GO:0005765,GO:0005770,GO:0005771,GO:0005829,GO:0005886,GO:0005887,GO:0008021,GO:0008626,GO:0009897,GO:0010008,GO:0016020,GO:0019899,GO:0019904,GO:0030425,GO:0035577,GO:0042383,GO:0042470,GO:0043025,GO:0043312,GO:0043323,GO:0044194,GO:0044754,GO:0045954,GO:0048102,GO:0048471,GO:0050821,GO:0061474,GO:0070062,GO:0072594,GO:0090160,GO:0097208,GO:0101003,GO:1902513 virus receptor activity|cytoplasm|lysosome|lysosomal membrane|late endosome|multivesicular body|cytosol|plasma membrane|integral component of plasma membrane|synaptic vesicle|granzyme-mediated apoptotic signaling pathway|external side of plasma membrane|endosome membrane|membrane|enzyme binding|protein domain specific binding|dendrite|azurophil granule membrane|sarcolemma|melanosome|neuronal cell body|neutrophil degranulation|positive regulation of natural killer cell degranulation|cytolytic granule|autolysosome|positive regulation of natural killer cell mediated cytotoxicity|autophagic cell death|perinuclear region of cytoplasm|protein stabilization|phagolysosome membrane|extracellular exosome|establishment of protein localization to organelle|Golgi to lysosome transport|alveolar lamellar body|ficolin-1-rich granule membrane|regulation of organelle transport along microtubule hsa04140,hsa04142,hsa04145,hsa05152 Autophagy - animal|Lysosome|Phagosome|Tuberculosis LAMP2 12622.6967782049 12587.6514812308 12657.742075179 1.00556820261927 0.00801093568969293 0.928761883212325 1 60.5346 58.6208 65.6691 54.4573 GeneID:3920,Genbank:NM_001122606.1,HGNC:HGNC:6501,MIM:309060 lysosomal associated membrane protein 2 GO:0002576,GO:0005615,GO:0005764,GO:0005765,GO:0005770,GO:0005802,GO:0005886,GO:0006605,GO:0009267,GO:0016020,GO:0017038,GO:0019899,GO:0019904,GO:0030670,GO:0031088,GO:0031647,GO:0031902,GO:0032463,GO:0035577,GO:0043202,GO:0043312,GO:0044754,GO:0046716,GO:0048471,GO:0050821,GO:0061684,GO:0061740,GO:0061742,GO:0070062,GO:0097352,GO:0097637,GO:0101003,GO:1905146 platelet degranulation|extracellular space|lysosome|lysosomal membrane|late endosome|trans-Golgi network|plasma membrane|protein targeting|cellular response to starvation|membrane|protein import|enzyme binding|protein domain specific binding|phagocytic vesicle membrane|platelet dense granule membrane|regulation of protein stability|late endosome membrane|negative regulation of protein homooligomerization|azurophil granule membrane|lysosomal lumen|neutrophil degranulation|autolysosome|muscle cell cellular homeostasis|perinuclear region of cytoplasm|protein stabilization|chaperone-mediated autophagy|protein targeting to lysosome involved in chaperone-mediated autophagy|chaperone-mediated autophagy translocation complex|extracellular exosome|autophagosome maturation|integral component of autophagosome membrane|ficolin-1-rich granule membrane|lysosomal protein catabolic process hsa04140,hsa04142,hsa04145,hsa05152 Autophagy - animal|Lysosome|Phagosome|Tuberculosis LAMP3 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00606284 0 GeneID:27074,Genbank:NM_014398.3,HGNC:HGNC:14582,MIM:605883 lysosomal associated membrane protein 3 GO:0002250,GO:0005765,GO:0005769,GO:0005886,GO:0010506,GO:0010628,GO:0016021,GO:0031982,GO:0035455,GO:0043154,GO:0043231,GO:0048471,GO:0097233,GO:1901799,GO:1903900 adaptive immune response|lysosomal membrane|early endosome|plasma membrane|regulation of autophagy|positive regulation of gene expression|integral component of membrane|vesicle|response to interferon-alpha|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|alveolar lamellar body membrane|negative regulation of proteasomal protein catabolic process|regulation of viral life cycle hsa04142 Lysosome LAMTOR1 1585.81017098714 1539.51713724331 1632.10320473096 1.06013967967478 0.0842543609187864 0.578104402949959 1 56.1305 56.5598 56.9479 64.5095 GeneID:55004,Genbank:NM_017907.2,HGNC:HGNC:26068,MIM:613510 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 GO:0001558,GO:0001919,GO:0005085,GO:0005764,GO:0005765,GO:0005886,GO:0007032,GO:0007040,GO:0010872,GO:0010874,GO:0031902,GO:0032008,GO:0032418,GO:0032439,GO:0032947,GO:0034613,GO:0042632,GO:0043410,GO:0045121,GO:0060620,GO:0071230,GO:0071986 regulation of cell growth|regulation of receptor recycling|guanyl-nucleotide exchange factor activity|lysosome|lysosomal membrane|plasma membrane|endosome organization|lysosome organization|regulation of cholesterol esterification|regulation of cholesterol efflux|late endosome membrane|positive regulation of TOR signaling|lysosome localization|endosome localization|protein complex scaffold activity|cellular protein localization|cholesterol homeostasis|positive regulation of MAPK cascade|membrane raft|regulation of cholesterol import|cellular response to amino acid stimulus|Ragulator complex hsa04150 mTOR signaling pathway LAMTOR2 644.959851317777 667.253323046715 622.666379588839 0.933178386801749 -0.0997752012118679 0.654413888067208 1 44.4851 40.1504 35.2559 46.3846 GeneID:28956,Genbank:NM_014017.3,HGNC:HGNC:29796,MIM:610389 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 hsa04150 mTOR signaling pathway LAMTOR3 446.607019855759 479.81877578325 413.395263928269 0.861565417596359 -0.214967752228463 0.236077925154124 1 4.97721 4.93797 4.53373 4.07405 GeneID:8649,Genbank:NM_001243736.1,HGNC:HGNC:15606,MIM:603296 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 GO:0000165,GO:0000186,GO:0005765,GO:0005886,GO:0005925,GO:0007050,GO:0010008,GO:0016241,GO:0019209,GO:0032008,GO:0034613,GO:0035579,GO:0043312,GO:0070062,GO:0070821,GO:0071230,GO:0071986 MAPK cascade|activation of MAPKK activity|lysosomal membrane|plasma membrane|focal adhesion|cell cycle arrest|endosome membrane|regulation of macroautophagy|kinase activator activity|positive regulation of TOR signaling|cellular protein localization|specific granule membrane|neutrophil degranulation|extracellular exosome|tertiary granule membrane|cellular response to amino acid stimulus|Ragulator complex hsa04010,hsa04150 MAPK signaling pathway|mTOR signaling pathway LAMTOR4 1114.22843795411 1034.00496015103 1194.45191575718 1.15517039258952 0.208105671046458 0.494386213908551 1 27.958 32.1047 33.2391 41.8105 GeneID:389541,Genbank:XM_024446761.1,HGNC:HGNC:33772 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 GO:0005085,GO:0005764,GO:0008361,GO:0032008,GO:0032947,GO:0061462,GO:0071230,GO:0071986 guanyl-nucleotide exchange factor activity|lysosome|regulation of cell size|positive regulation of TOR signaling|protein complex scaffold activity|protein localization to lysosome|cellular response to amino acid stimulus|Ragulator complex hsa04150 mTOR signaling pathway LAMTOR5 1629.89558641328 1562.29074445167 1697.50042837489 1.08654578823014 0.119748972550166 0.495372922584686 1 80.7983 85.1763 86.0939 99.5182 GeneID:10542,Genbank:NM_006402.2,HGNC:HGNC:17955,MIM:608521 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 GO:0005764,GO:0005765,GO:0005829,GO:0007050,GO:0008361,GO:0009615,GO:0016241,GO:0019079,GO:0032008,GO:0043066,GO:0043154,GO:0061462,GO:0071230,GO:0071986 lysosome|lysosomal membrane|cytosol|cell cycle arrest|regulation of cell size|response to virus|regulation of macroautophagy|viral genome replication|positive regulation of TOR signaling|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein localization to lysosome|cellular response to amino acid stimulus|Ragulator complex hsa04150,hsa05161 mTOR signaling pathway|Hepatitis B LANCL1 996.290980903942 1051.82474206086 940.757219747028 0.894404915693262 -0.160999977561802 0.554907685687769 1 11.5425 9.1417 10.7041 8.17247 GeneID:10314,Genbank:NM_001136575.1,HGNC:HGNC:6508,MIM:604155 LanC like 1 GO:0004930,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0008270,GO:0017124,GO:0043295,GO:0050750,GO:0070062 G-protein coupled receptor activity|cytoplasm|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|zinc ion binding|SH3 domain binding|glutathione binding|low-density lipoprotein particle receptor binding|extracellular exosome LANCL2 938.799860225971 992.203795159749 885.395925292192 0.892352891221949 -0.164313741541077 0.281143552896342 1 9.41194 10.137 8.78596 8.86257 GeneID:55915,Genbank:NM_018697.3,HGNC:HGNC:6509,MIM:612919 LanC like 2 GO:0005524,GO:0005525,GO:0005634,GO:0005829,GO:0005886,GO:0009789,GO:0010314,GO:0030864,GO:0032266,GO:0045892,GO:0070273 ATP binding|GTP binding|nucleus|cytosol|plasma membrane|positive regulation of abscisic acid-activated signaling pathway|phosphatidylinositol-5-phosphate binding|cortical actin cytoskeleton|phosphatidylinositol-3-phosphate binding|negative regulation of transcription, DNA-templated|phosphatidylinositol-4-phosphate binding LANCL3 56.2578878445478 53.8686195948781 58.6471560942175 1.08870723874636 0.122616055072048 0.797604154805361 1 0.174074 0.25681 0.25213 0.178124 GeneID:347404,Genbank:NM_198511.2,HGNC:HGNC:24767 LanC like 3 GO:0005886,GO:0007165 plasma membrane|signal transduction LAP3 2421.75315710044 2273.43673726388 2570.06957693699 1.13047771895783 0.176932557710118 0.626595474098638 1 38.7403 37.7775 55.5888 31.8109 GeneID:51056,Genbank:NM_015907.2,HGNC:HGNC:18449,MIM:170250 leucine aminopeptidase 3 GO:0004177,GO:0005634,GO:0005654,GO:0005739,GO:0005802,GO:0005829,GO:0005925,GO:0006508,GO:0008235,GO:0030145,GO:0030496,GO:0070062 aminopeptidase activity|nucleus|nucleoplasm|mitochondrion|trans-Golgi network|cytosol|focal adhesion|proteolysis|metalloexopeptidase activity|manganese ion binding|midbody|extracellular exosome hsa00330,hsa00480 Arginine and proline metabolism|Glutathione metabolism LAPTM4A 5249.96942184066 5145.1718257234 5354.76701795793 1.04073628623765 0.0576045482381196 0.656184036339266 1 165.08 158.387 179.229 162.346 GeneID:9741,Genbank:NM_014713.4,HGNC:HGNC:6924 lysosomal protein transmembrane 4 alpha GO:0005765,GO:0005794,GO:0016021,GO:0031902 lysosomal membrane|Golgi apparatus|integral component of membrane|late endosome membrane hsa04142 Lysosome LAPTM4B 5501.90358450585 5767.93756339903 5235.86960561266 0.907754209899452 -0.139626379047252 0.29129450826871 1 136.43 137.976 127.036 124.342 GeneID:55353,Genbank:NM_018407.4,HGNC:HGNC:13646,MIM:613296 lysosomal protein transmembrane 4 beta GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005886,GO:0007032,GO:0016021,GO:0019900,GO:0031625,GO:0031902,GO:0032509,GO:0032585,GO:0032911,GO:0042995,GO:0097001,GO:0097213,GO:0097487,GO:1902936,GO:1905166,GO:1905671 lysosome|lysosomal membrane|endosome|early endosome|plasma membrane|endosome organization|integral component of membrane|kinase binding|ubiquitin protein ligase binding|late endosome membrane|endosome transport via multivesicular body sorting pathway|multivesicular body membrane|negative regulation of transforming growth factor beta1 production|cell projection|ceramide binding|regulation of lysosomal membrane permeability|multivesicular body, internal vesicle|phosphatidylinositol bisphosphate binding|negative regulation of lysosomal protein catabolic process|regulation of lysosome organization hsa04142 Lysosome LAPTM5 117.541107630943 127.983037148316 107.099178113571 0.836823226733213 -0.257005199531258 0.366673564395171 1 2.60517 2.34044 2.08439 2.09256 GeneID:7805,Genbank:NM_006762.2,HGNC:HGNC:29612,MIM:601476 lysosomal protein transmembrane 5 GO:0005764,GO:0005765,GO:0005887,GO:1990830 lysosome|lysosomal membrane|integral component of plasma membrane|cellular response to leukemia inhibitory factor hsa04142 Lysosome LARGE1 490.608244776947 388.02357013977 593.192919414124 1.52875486198029 0.61235708703963 0.000480046382626639 0.0605387627098288 1.62338 1.70436 2.71569 2.51166 GeneID:9215,Genbank:XM_024452302.1,HGNC:HGNC:6511,MIM:603590 LARGE xylosyl- and glucuronyltransferase 1 hsa00515 Mannose type O-glycan biosynthesis LARGE2 9.51548797649475 12.7320477957835 6.29892815720603 0.494730168959315 -1.01528621625016 0.288696908138693 1 0.16325 0.138253 0.0562669 0.140223 GeneID:120071,Genbank:NM_152312.4,HGNC:HGNC:16522,MIM:609709 LARGE xylosyl- and glucuronyltransferase 2 hsa00515 Mannose type O-glycan biosynthesis LARP1 10147.6479856918 10335.8577332482 9959.43823813541 0.963581203918672 -0.0535218429442266 0.678047094262699 1 43.6116 43.48 45.1953 40.1613 GeneID:23367,Genbank:XM_017009283.1,HGNC:HGNC:29531,MIM:612059 La ribonucleoprotein domain family member 1 GO:0000339,GO:0003723,GO:0003730,GO:0005737,GO:0006413,GO:0008190,GO:0008283,GO:0008494,GO:0010494,GO:0016020,GO:0016239,GO:0017148,GO:0031369,GO:0031929,GO:0038202,GO:0045070,GO:0045296,GO:0048027,GO:0048255,GO:0072752,GO:1990928 RNA cap binding|RNA binding|mRNA 3'-UTR binding|cytoplasm|translational initiation|eukaryotic initiation factor 4E binding|cell proliferation|translation activator activity|cytoplasmic stress granule|membrane|positive regulation of macroautophagy|negative regulation of translation|translation initiation factor binding|TOR signaling|TORC1 signaling|positive regulation of viral genome replication|cadherin binding|mRNA 5'-UTR binding|mRNA stabilization|cellular response to rapamycin|response to amino acid starvation LARP1B 251.274654808286 272.839207371283 229.71010224529 0.841924826195148 -0.248236671235942 0.25733566599189 1 0.937948 0.838664 0.778015 0.71206 GeneID:55132,Genbank:XM_017008340.1,HGNC:HGNC:24704 La ribonucleoprotein domain family member 1B GO:0003723,GO:0005634 RNA binding|nucleus LARP4 526.625310400283 544.32387039628 508.926750404286 0.93497048004486 -0.0970072795824929 0.692267380062188 1 2.19806 2.01955 2.27355 1.65689 GeneID:113251,Genbank:NM_001352306.1,HGNC:HGNC:24320 La ribonucleoprotein domain family member 4 GO:0003723,GO:0005829,GO:0006412,GO:0007010,GO:0008143,GO:0010494,GO:0016020,GO:0022604,GO:0045727 RNA binding|cytosol|translation|cytoskeleton organization|poly(A) binding|cytoplasmic stress granule|membrane|regulation of cell morphogenesis|positive regulation of translation LARP4B 1635.54005869361 1710.00008219126 1561.08003519595 0.912912257404994 -0.131451889540687 0.362049015812589 1 4.99531 5.0311 4.95872 4.0671 GeneID:23185,Genbank:NM_015155.2,HGNC:HGNC:28987,MIM:616513 La ribonucleoprotein domain family member 4B GO:0003723,GO:0005730,GO:0005829,GO:0010494,GO:0016020,GO:0042788,GO:0045727 RNA binding|nucleolus|cytosol|cytoplasmic stress granule|membrane|polysomal ribosome|positive regulation of translation LARP6 1742.77675041191 1713.35516376667 1772.19833705716 1.03434382697463 0.0487158326721897 0.747375301603286 1 17.7611 19.3444 19.1555 20.294 GeneID:55323,Genbank:NM_018357.3,HGNC:HGNC:24012,MIM:611300 La ribonucleoprotein domain family member 6 GO:0005634,GO:0005737,GO:0005844,GO:0006396,GO:0017022,GO:0030529,GO:0032967,GO:0035613,GO:0045727,GO:0048027,GO:1902416,GO:1990825 nucleus|cytoplasm|polysome|RNA processing|myosin binding|intracellular ribonucleoprotein complex|positive regulation of collagen biosynthetic process|RNA stem-loop binding|positive regulation of translation|mRNA 5'-UTR binding|positive regulation of mRNA binding|sequence-specific mRNA binding LARP7 259.408466815899 264.825577151442 253.991356480357 0.959089220959617 -0.0602630641604755 0.84808127612142 1 1.48292 1.6099 1.82045 1.25238 GeneID:51574,Genbank:NM_001267039.1,HGNC:HGNC:24912,MIM:612026 La ribonucleoprotein domain family member 7 GO:0003723,GO:0005654,GO:0005829,GO:0006396,GO:0030529 RNA binding|nucleoplasm|cytosol|RNA processing|intracellular ribonucleoprotein complex LARS 3024.22290943646 3290.36934023554 2758.07647863738 0.838227017529875 -0.254587072072857 0.0680100487374995 0.916876212609253 23.1788 20.6187 19.3753 17.3716 GeneID:51520,Genbank:NM_001317965.1,HGNC:HGNC:6512,MIM:151350 leucyl-tRNA synthetase GO:0002161,GO:0004819,GO:0004823,GO:0004832,GO:0005096,GO:0005524,GO:0005737,GO:0005764,GO:0005783,GO:0005829,GO:0006418,GO:0006425,GO:0006429,GO:0006438,GO:0006622,GO:0008361,GO:0010507,GO:0012505,GO:0016604,GO:0017101,GO:0034198,GO:0043547,GO:0071230,GO:0071233,GO:1904263,GO:1990253 aminoacyl-tRNA editing activity|glutamine-tRNA ligase activity|leucine-tRNA ligase activity|valine-tRNA ligase activity|GTPase activator activity|ATP binding|cytoplasm|lysosome|endoplasmic reticulum|cytosol|tRNA aminoacylation for protein translation|glutaminyl-tRNA aminoacylation|leucyl-tRNA aminoacylation|valyl-tRNA aminoacylation|protein targeting to lysosome|regulation of cell size|negative regulation of autophagy|endomembrane system|nuclear body|aminoacyl-tRNA synthetase multienzyme complex|cellular response to amino acid starvation|positive regulation of GTPase activity|cellular response to amino acid stimulus|cellular response to leucine|positive regulation of TORC1 signaling|cellular response to leucine starvation hsa00970 Aminoacyl-tRNA biosynthesis LARS2 1553.52896952183 1480.99876065825 1626.0591783854 1.09794769690603 0.13480933010672 0.366761697875062 1 8.45969 9.61552 11.3695 8.99355 GeneID:23395,Genbank:XM_005265006.2,HGNC:HGNC:17095,MIM:604544 leucyl-tRNA synthetase 2, mitochondrial GO:0002161,GO:0004823,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006429,GO:0032543 aminoacyl-tRNA editing activity|leucine-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|leucyl-tRNA aminoacylation|mitochondrial translation hsa00970 Aminoacyl-tRNA biosynthesis LAS1L 2321.27995986375 2347.92860736225 2294.63131236524 0.977300291486762 -0.0331261729458988 0.799048514108975 1 15.1389 16.1015 15.0347 15.6492 GeneID:81887,Genbank:NM_001170650.1,HGNC:HGNC:25726,MIM:300964 LAS1 like, ribosome biogenesis factor GO:0000460,GO:0000470,GO:0000478,GO:0003723,GO:0005654,GO:0005730,GO:0005737,GO:0006325,GO:0006364,GO:0016020,GO:0030687,GO:0071339 maturation of 5.8S rRNA|maturation of LSU-rRNA|endonucleolytic cleavage involved in rRNA processing|RNA binding|nucleoplasm|nucleolus|cytoplasm|chromatin organization|rRNA processing|membrane|preribosome, large subunit precursor|MLL1 complex LASP1 12675.7927997349 12259.3300839416 13092.2555155282 1.06794216534537 0.0948335196577821 0.475706587046863 1 120.888 126.815 137.717 131.356 GeneID:3927,Genbank:NM_006148.3,HGNC:HGNC:6513,MIM:602920 LIM and SH3 protein 1 LAT 13.8409935593226 10.7237359132691 16.9582512053762 1.58137531010931 0.661179805252196 0.41193404057414 1 0.193547 0.14262 0.28063 0.262199 GeneID:27040,Genbank:NM_001014989.1,HGNC:HGNC:18874,MIM:602354 linker for activation of T cells GO:0000165,GO:0001772,GO:0002250,GO:0002260,GO:0005070,GO:0005088,GO:0005794,GO:0005886,GO:0005911,GO:0006954,GO:0006955,GO:0007229,GO:0007265,GO:0008180,GO:0010467,GO:0016021,GO:0019722,GO:0019901,GO:0030168,GO:0035556,GO:0038095,GO:0042110,GO:0042629,GO:0043303,GO:0045121,GO:0045860,GO:0050852,GO:0050863 MAPK cascade|immunological synapse|adaptive immune response|lymphocyte homeostasis|SH3/SH2 adaptor activity|Ras guanyl-nucleotide exchange factor activity|Golgi apparatus|plasma membrane|cell-cell junction|inflammatory response|immune response|integrin-mediated signaling pathway|Ras protein signal transduction|COP9 signalosome|gene expression|integral component of membrane|calcium-mediated signaling|protein kinase binding|platelet activation|intracellular signal transduction|Fc-epsilon receptor signaling pathway|T cell activation|mast cell granule|mast cell degranulation|membrane raft|positive regulation of protein kinase activity|T cell receptor signaling pathway|regulation of T cell activation hsa04014,hsa04015,hsa04064,hsa04650,hsa04658,hsa04659,hsa04660,hsa04664,hsa04666 Ras signaling pathway|Rap1 signaling pathway|NF-kappa B signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis LAT2 22.3813643321266 25.8581144441544 18.9046142200987 0.731090206168235 -0.451878669609069 0.44757378826252 1 0.278176 0.415241 0.243206 0.211233 GeneID:7462,Genbank:NM_032464.2,HGNC:HGNC:12749,MIM:605719 linker for activation of T cells family member 2 GO:0002250,GO:0005886,GO:0016021,GO:0019722,GO:0035556,GO:0038095,GO:0042113,GO:0042169,GO:0042629,GO:0043303,GO:0045121,GO:0050853,GO:0070062 adaptive immune response|plasma membrane|integral component of membrane|calcium-mediated signaling|intracellular signal transduction|Fc-epsilon receptor signaling pathway|B cell activation|SH2 domain binding|mast cell granule|mast cell degranulation|membrane raft|B cell receptor signaling pathway|extracellular exosome LATS1 263.538805894815 298.7835657097 228.294046079931 0.764078323845105 -0.388207561821142 0.188653494215985 1 1.43892 1.16303 1.17299 0.825913 GeneID:9113,Genbank:NM_001350392.1,HGNC:HGNC:6514,MIM:603473 large tumor suppressor kinase 1 hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species LATS2 484.988337704883 468.874525806772 501.102149602994 1.06873400456288 0.0959028277547963 0.594846002267636 1 2.82659 2.99986 3.14761 3.11457 GeneID:26524,Genbank:NM_014572.2,HGNC:HGNC:6515,MIM:604861 large tumor suppressor kinase 2 hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species LAX1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:54900,Genbank:XM_006711397.3,HGNC:HGNC:26005 lymphocyte transmembrane adaptor 1 GO:0000188,GO:0002250,GO:0005794,GO:0005829,GO:0005886,GO:0006955,GO:0016020,GO:0016021,GO:0019901,GO:0035556,GO:0042113,GO:0042169,GO:0050868 inactivation of MAPK activity|adaptive immune response|Golgi apparatus|cytosol|plasma membrane|immune response|membrane|integral component of membrane|protein kinase binding|intracellular signal transduction|B cell activation|SH2 domain binding|negative regulation of T cell activation LAYN 3565.44512424587 3610.86927946311 3520.02096902863 0.974840321428644 -0.0367621697164644 0.764649213332713 1 38.8998 43.809 43.6301 37.3447 GeneID:143903,Genbank:NM_001318799.1,HGNC:HGNC:29471 layilin GO:0001726,GO:0005540,GO:0005925,GO:0009986,GO:0016021,GO:0030246 ruffle|hyaluronic acid binding|focal adhesion|cell surface|integral component of membrane|carbohydrate binding LBH 277.818421788813 261.020675795368 294.616167782257 1.12870816415028 0.174672514845479 0.466615059268882 1 3.48864 3.60636 3.69244 4.447 GeneID:81606,Genbank:NM_030915.3,HGNC:HGNC:29532,MIM:611763 limb bud and heart development GO:0005634,GO:0005737,GO:0006351,GO:0033147,GO:0045893,GO:0060644,GO:1904674,GO:1904677,GO:2000103,GO:2000737 nucleus|cytoplasm|transcription, DNA-templated|negative regulation of intracellular estrogen receptor signaling pathway|positive regulation of transcription, DNA-templated|mammary gland epithelial cell differentiation|positive regulation of somatic stem cell population maintenance|positive regulation of somatic stem cell division|positive regulation of mammary stem cell proliferation|negative regulation of stem cell differentiation LBHD1 42.2647707711492 48.1798678701295 36.3496736721688 0.754457728488394 -0.406488024630559 0.359867649981961 1 0.926095 1.09537 0.967642 0.603905 GeneID:79081,Genbank:NM_024099.3,HGNC:HGNC:28351 LBH domain containing 1 LBP 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.023948 0 0 0 GeneID:3929,Genbank:NM_004139.4,HGNC:HGNC:6517,MIM:151990 lipopolysaccharide binding protein GO:0001530,GO:0002224,GO:0002232,GO:0002281,GO:0005102,GO:0005576,GO:0005615,GO:0006953,GO:0006968,GO:0008228,GO:0009986,GO:0015920,GO:0016020,GO:0019221,GO:0031663,GO:0032490,GO:0032496,GO:0032720,GO:0032722,GO:0032755,GO:0032757,GO:0032760,GO:0033036,GO:0034142,GO:0034145,GO:0042535,GO:0043032,GO:0044130,GO:0045087,GO:0045919,GO:0050829,GO:0050830,GO:0060265,GO:0070062,GO:0070891,GO:0071222,GO:0071223,GO:0071723,GO:0090023 lipopolysaccharide binding|toll-like receptor signaling pathway|leukocyte chemotaxis involved in inflammatory response|macrophage activation involved in immune response|receptor binding|extracellular region|extracellular space|acute-phase response|cellular defense response|opsonization|cell surface|lipopolysaccharide transport|membrane|cytokine-mediated signaling pathway|lipopolysaccharide-mediated signaling pathway|detection of molecule of bacterial origin|response to lipopolysaccharide|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|macromolecule localization|toll-like receptor 4 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of macrophage activation|negative regulation of growth of symbiont in host|innate immune response|positive regulation of cytolysis|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|positive regulation of respiratory burst involved in inflammatory response|extracellular exosome|lipoteichoic acid binding|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|lipopeptide binding|positive regulation of neutrophil chemotaxis hsa04064,hsa04620,hsa05132,hsa05152 NF-kappa B signaling pathway|Toll-like receptor signaling pathway|Salmonella infection|Tuberculosis LBR 2193.58566940392 2395.15267338952 1992.01866541832 0.831687552760177 -0.265886454434965 0.116055006107951 1 29.1879 26.0685 26.642 20.3008 GeneID:3930,Genbank:NM_194442.2,HGNC:HGNC:6518,MIM:600024 lamin B receptor GO:0003677,GO:0003723,GO:0005521,GO:0005635,GO:0005639,GO:0006695,GO:0016020,GO:0016021,GO:0016126,GO:0016627,GO:0031965,GO:0050613,GO:0070087 DNA binding|RNA binding|lamin binding|nuclear envelope|integral component of nuclear inner membrane|cholesterol biosynthetic process|membrane|integral component of membrane|sterol biosynthetic process|oxidoreductase activity, acting on the CH-CH group of donors|nuclear membrane|delta14-sterol reductase activity|chromo shadow domain binding LBX2 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0388189 0 0.0355686 0 GeneID:85474,Genbank:NM_001009812.1,HGNC:HGNC:15525,MIM:607164 ladybird homeobox 2 GO:0003677,GO:0005634,GO:0006351,GO:0006355 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated LCA5 89.9357769761155 93.6016037721466 86.2699501800843 0.921671709707991 -0.117675126354334 0.749100275940228 1 0.750974 0.544597 0.68251 0.527705 GeneID:167691,Genbank:NM_001122769.2,HGNC:HGNC:31923,MIM:611408 LCA5, lebercilin GO:0005737,GO:0005815,GO:0005929,GO:0015031,GO:0032403 cytoplasm|microtubule organizing center|cilium|protein transport|protein complex binding LCA5L 2.22095982504192 2.98845468642911 1.45346496365472 0.486360047637681 -1.03990337236064 0.699627032121551 1 0 0.0279428 0 0.00862579 GeneID:150082,Genbank:XM_017028275.1,HGNC:HGNC:1255 LCA5L, lebercilin like LCAT 59.8490512415539 57.1834495489938 62.5146529341139 1.09322983183364 0.128596733480195 0.735936119804377 1 2.03033 1.69009 1.91813 1.85972 GeneID:3931,Genbank:NM_000229.1,HGNC:HGNC:6522,MIM:606967 lecithin-cholesterol acyltransferase hsa00564,hsa04979 Glycerophospholipid metabolism|Cholesterol metabolism LCE5A 2.72710472925976 2.54640955915669 2.90779989936283 1.14192152982877 0.1914635154849 1 1 0.144017 0.0630531 0.132899 0 GeneID:254910,Genbank:NM_178438.4,HGNC:HGNC:16614,MIM:612619 late cornified envelope 5A LCK 2.73504436434175 4.01662376502878 1.45346496365472 0.361862362193214 -1.46648703608823 0.492520912372774 1 0.0341466 0.089993 0.0159231 0.0296381 GeneID:3932,Genbank:NM_005356.4,HGNC:HGNC:6524,MIM:153390 LCK proto-oncogene, Src family tyrosine kinase hsa04064,hsa04380,hsa04650,hsa04658,hsa04659,hsa04660,hsa05166,hsa05340 NF-kappa B signaling pathway|Osteoclast differentiation|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Human T-cell leukemia virus 1 infection|Primary immunodeficiency LCLAT1 248.484687063731 270.61038142556 226.358992701903 0.836475642617466 -0.257604563932297 0.275510084506974 1 1.61358 1.57391 1.61185 1.05034 GeneID:253558,Genbank:NM_182551.4,HGNC:HGNC:26756,MIM:614241 lysocardiolipin acyltransferase 1 GO:0003841,GO:0005783,GO:0005789,GO:0005829,GO:0006654,GO:0007275,GO:0008374,GO:0016020,GO:0016021,GO:0016024,GO:0035965 1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|phosphatidic acid biosynthetic process|multicellular organism development|O-acyltransferase activity|membrane|integral component of membrane|CDP-diacylglycerol biosynthetic process|cardiolipin acyl-chain remodeling hsa00561,hsa00564 Glycerolipid metabolism|Glycerophospholipid metabolism LCMT1 540.51885819156 507.743037039711 573.294679343409 1.12910397094933 0.175178339491472 0.308473525016016 1 11.1919 11.401 12.5173 12.5775 GeneID:51451,Genbank:XM_005255354.4,HGNC:HGNC:17557,MIM:610286 leucine carboxyl methyltransferase 1 GO:0000086,GO:0003880,GO:0005654,GO:0005829,GO:0006464,GO:0006479,GO:0006481,GO:0008757,GO:0010906,GO:0018423,GO:0031333,GO:0042981,GO:0090266 G2/M transition of mitotic cell cycle|protein C-terminal carboxyl O-methyltransferase activity|nucleoplasm|cytosol|cellular protein modification process|protein methylation|C-terminal protein methylation|S-adenosylmethionine-dependent methyltransferase activity|regulation of glucose metabolic process|protein C-terminal leucine carboxyl O-methyltransferase activity|negative regulation of protein complex assembly|regulation of apoptotic process|regulation of mitotic cell cycle spindle assembly checkpoint LCMT2 797.474101733491 778.863107177445 816.085096289538 1.04779015563721 0.0673498125480394 0.680877784337395 1 12.7128 13.3288 13.5498 14.0429 GeneID:9836,Genbank:NM_014793.4,HGNC:HGNC:17558,MIM:611246 leucine carboxyl methyltransferase 2 LCN12 2.6951519568353 1.02816907859967 4.36213483507094 4.24262402542978 2.08495683496113 0.348083628734939 1 0.0159353 0 0.0291961 0 GeneID:286256,Genbank:XM_006717065.3,HGNC:HGNC:28733,MIM:612905 lipocalin 12 GO:0001972,GO:0005576,GO:0015909 retinoic acid binding|extracellular region|long-chain fatty acid transport LCN2 1.99950227537901 2.54640955915669 1.45259499160132 0.570448295081951 -0.80983196702256 0.825124353656361 1 0.0992916 0.136269 0 0.0436303 GeneID:3934,Genbank:NM_005564.4,HGNC:HGNC:6526,MIM:600181 lipocalin 2 GO:0005506,GO:0005576,GO:0005615,GO:0006811,GO:0006879,GO:0006915,GO:0015891,GO:0019221,GO:0019730,GO:0035580,GO:0036094,GO:0043312,GO:0045087,GO:0070062 iron ion binding|extracellular region|extracellular space|ion transport|cellular iron ion homeostasis|apoptotic process|siderophore transport|cytokine-mediated signaling pathway|antimicrobial humoral response|specific granule lumen|small molecule binding|neutrophil degranulation|innate immune response|extracellular exosome hsa04657 IL-17 signaling pathway LCOR 284.476854965831 278.124131588336 290.829578343326 1.04568264782502 0.064445077323979 0.833308004875982 1 0.688204 0.57592 0.812196 0.526704 GeneID:84458,Genbank:NM_001346516.1,HGNC:HGNC:29503,MIM:607698 ligand dependent nuclear receptor corepressor GO:0003677,GO:0005654,GO:0006351,GO:0006355 DNA binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated LCORL 216.359904665029 223.823275521294 208.896533808765 0.933310145346751 -0.0995715167032186 0.765994786065962 1 0.366789 0.266662 0.365031 0.216346 GeneID:254251,Genbank:NM_153686.8,HGNC:HGNC:30776,MIM:611799 ligand dependent nuclear receptor corepressor like GO:0003677,GO:0005634,GO:0006357,GO:0006366 DNA binding|nucleus|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter LCP1 167.615422014617 148.632662614571 186.598181414663 1.25543186895967 0.328183737107154 0.166778432396587 1 1.23323 1.06781 1.6566 1.3457 GeneID:3936,Genbank:NM_002298.4,HGNC:HGNC:6528,MIM:153430 lymphocyte cytosolic protein 1 LCT 1.53725051852931 2.10436443188427 0.97013660517434 0.46101169097677 -1.11712475789794 0.810649691230945 1 0.0120659 0.00544308 0.011369 0 GeneID:3938,Genbank:NM_002299.3,HGNC:HGNC:6530,MIM:603202 lactase hsa00052,hsa04973 Galactose metabolism|Carbohydrate digestion and absorption LCTL 230.248278166696 252.603218067831 207.893338265561 0.823003522503565 -0.281029489407474 0.194495427418613 1 1.75796 1.9195 1.5317 1.69201 GeneID:197021,Genbank:NM_001278562.1,HGNC:HGNC:15583,MIM:617060 lactase like GO:0005783,GO:0005789,GO:0005903,GO:0005975,GO:0008422,GO:0016021,GO:1901657 endoplasmic reticulum|endoplasmic reticulum membrane|brush border|carbohydrate metabolic process|beta-glucosidase activity|integral component of membrane|glycosyl compound metabolic process LDAH 210.894867077676 227.455689088843 194.334045066509 0.85438199345545 -0.227046853089275 0.331047024317429 1 1.99015 1.81238 1.68454 1.70796 GeneID:60526,Genbank:NM_001282722.1,HGNC:HGNC:26145,MIM:613570 lipid droplet associated hydrolase GO:0005783,GO:0005811,GO:0016042,GO:0016298,GO:0019915 endoplasmic reticulum|lipid droplet|lipid catabolic process|lipase activity|lipid storage LDB1 1774.13291445907 1622.43220572091 1925.83362319723 1.1870040648888 0.247324875489401 0.0797423444450814 0.946740836643754 15.7533 13.7128 17.5368 18.3059 GeneID:8861,Genbank:XM_017016868.1,HGNC:HGNC:6532,MIM:603451 LIM domain binding 1 GO:0000790,GO:0000972,GO:0000989,GO:0001102,GO:0001158,GO:0001702,GO:0001942,GO:0003682,GO:0005634,GO:0005654,GO:0005667,GO:0006366,GO:0009948,GO:0010669,GO:0016055,GO:0019899,GO:0021549,GO:0021702,GO:0022607,GO:0030182,GO:0030274,GO:0030334,GO:0031252,GO:0032784,GO:0035019,GO:0042803,GO:0043234,GO:0043549,GO:0043621,GO:0043973,GO:0045647,GO:0045785,GO:0045892,GO:0045944,GO:0046985,GO:0051893,GO:0060319,GO:0060322 nuclear chromatin|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|transcription factor activity, transcription factor binding|RNA polymerase II activating transcription factor binding|enhancer sequence-specific DNA binding|gastrulation with mouth forming second|hair follicle development|chromatin binding|nucleus|nucleoplasm|transcription factor complex|transcription from RNA polymerase II promoter|anterior/posterior axis specification|epithelial structure maintenance|Wnt signaling pathway|enzyme binding|cerebellum development|cerebellar Purkinje cell differentiation|cellular component assembly|neuron differentiation|LIM domain binding|regulation of cell migration|cell leading edge|regulation of DNA-templated transcription, elongation|somatic stem cell population maintenance|protein homodimerization activity|protein complex|regulation of kinase activity|protein self-association|histone H3-K4 acetylation|negative regulation of erythrocyte differentiation|positive regulation of cell adhesion|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of hemoglobin biosynthetic process|regulation of focal adhesion assembly|primitive erythrocyte differentiation|head development hsa05202 Transcriptional misregulation in cancer LDB2 14.9172018188021 17.719005709619 12.1153979279851 0.683751567471309 -0.548455859661522 0.499108695519813 1 0.223106 0.0596486 0.0912588 0.104072 GeneID:9079,Genbank:NM_001304434.1,HGNC:HGNC:6533,MIM:603450 LIM domain binding 2 GO:0001942,GO:0003712,GO:0005634,GO:0005667,GO:0005730,GO:0005886,GO:0010669,GO:0019899,GO:0030274,GO:0030334,GO:0031252,GO:0035019,GO:0043549,GO:0044089,GO:0045944 hair follicle development|transcription cofactor activity|nucleus|transcription factor complex|nucleolus|plasma membrane|epithelial structure maintenance|enzyme binding|LIM domain binding|regulation of cell migration|cell leading edge|somatic stem cell population maintenance|regulation of kinase activity|positive regulation of cellular component biogenesis|positive regulation of transcription from RNA polymerase II promoter LDB3 4.77506826535041 5.18887166768327 4.36126486301754 0.840503512580561 -0.25067424619098 0.947536898640231 1 0.0209485 0.0161677 0.0223562 0.0183654 GeneID:11155,Genbank:XM_011539185.2,HGNC:HGNC:15710,MIM:605906 LIM domain binding 3 GO:0005080,GO:0005856,GO:0008092,GO:0030018,GO:0031143,GO:0045214,GO:0046872,GO:0048471,GO:0051371 protein kinase C binding|cytoskeleton|cytoskeletal protein binding|Z disc|pseudopodium|sarcomere organization|metal ion binding|perinuclear region of cytoplasm|muscle alpha-actinin binding LDHA 860.457865353965 767.658091516471 953.257639191459 1.24177371374845 0.312402297715863 0.0441296188682346 0.784836632957795 13.3274 12.66 16.2872 16.1269 GeneID:3939,Genbank:NM_005566.3,HGNC:HGNC:6535,MIM:150000 lactate dehydrogenase A hsa00010,hsa00270,hsa00620,hsa00640,hsa04066,hsa04922,hsa05230 Glycolysis / Gluconeogenesis|Cysteine and methionine metabolism|Pyruvate metabolism|Propanoate metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer LDHB 11589.3544261406 12431.2493877732 10747.459464508 0.864551834595056 -0.20997563099504 0.109702889109806 1 182.8 175.066 158.815 154.366 GeneID:3945,Genbank:NM_002300.7,HGNC:HGNC:6541,MIM:150100 lactate dehydrogenase B hsa00010,hsa00270,hsa00620,hsa00640,hsa04922 Glycolysis / Gluconeogenesis|Cysteine and methionine metabolism|Pyruvate metabolism|Propanoate metabolism|Glucagon signaling pathway LDHD 1.2374454993887 0.538097676642304 1.93679332213509 3.5993341101574 1.84773002743481 0.680703344325985 1 0.0246543 0 0 0.0843993 GeneID:197257,Genbank:NM_194436.2,HGNC:HGNC:19708,MIM:607490 lactate dehydrogenase D GO:0004458,GO:0005739,GO:0005743,GO:0050660 D-lactate dehydrogenase (cytochrome) activity|mitochondrion|mitochondrial inner membrane|flavin adenine dinucleotide binding hsa00620 Pyruvate metabolism LDLR 4525.57002477034 3862.49133772617 5188.6487118145 1.34334248497474 0.425827166555192 0.00153274073252033 0.137141762972322 25.4511 27.0065 38.6957 33.8368 GeneID:3949,Genbank:NM_000527.4,HGNC:HGNC:6547,MIM:606945 low density lipoprotein receptor hsa04144,hsa04913,hsa04925,hsa04927,hsa04934,hsa04976,hsa04979,hsa05145,hsa05160 Endocytosis|Ovarian steroidogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome|Bile secretion|Cholesterol metabolism|Toxoplasmosis|Hepatitis C LDLRAD2 4.83027256953904 6.26506702096788 3.39547811811019 0.541969959259211 -0.883715207937127 0.587742439707546 1 0.0708082 0.0203233 0.0435041 0 GeneID:401944,Genbank:XM_005245873.4,HGNC:HGNC:32071 low density lipoprotein receptor class A domain containing 2 GO:0016021 integral component of membrane LDLRAD3 676.978583315748 657.019658535403 696.937508096094 1.06075594396928 0.0850927628247127 0.601694789288082 1 7.13168 6.9878 8.43366 7.07939 GeneID:143458,Genbank:NM_174902.3,HGNC:HGNC:27046 low density lipoprotein receptor class A domain containing 3 GO:0001540,GO:0005886,GO:0006898,GO:0016021,GO:0070613 amyloid-beta binding|plasma membrane|receptor-mediated endocytosis|integral component of membrane|regulation of protein processing LDLRAD4 232.031218521794 231.434095234295 232.628341809293 1.00516020154156 0.00742545518586682 0.969884396321586 1 0.430634 0.373947 0.4272 0.410558 GeneID:753,Genbank:XM_024451253.1,HGNC:HGNC:1224,MIM:606571 low density lipoprotein receptor class A domain containing 4 GO:0005654,GO:0010719,GO:0010991,GO:0016021,GO:0030336,GO:0030512,GO:0031901,GO:0043231,GO:0060394,GO:0070412 nucleoplasm|negative regulation of epithelial to mesenchymal transition|negative regulation of SMAD protein complex assembly|integral component of membrane|negative regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|early endosome membrane|intracellular membrane-bounded organelle|negative regulation of pathway-restricted SMAD protein phosphorylation|R-SMAD binding LDLRAP1 527.698251580167 575.113141826187 480.283361334148 0.835111087548929 -0.25995997538916 0.122110302336904 1 3.2476 3.94568 3.20119 2.8333 GeneID:26119,Genbank:NM_015627.2,HGNC:HGNC:18640,MIM:605747 low density lipoprotein receptor adaptor protein 1 GO:0001540,GO:0001784,GO:0005546,GO:0005769,GO:0005829,GO:0005883,GO:0005886,GO:0006898,GO:0008203,GO:0009898,GO:0009925,GO:0030159,GO:0030276,GO:0030301,GO:0030424,GO:0030665,GO:0031623,GO:0034383,GO:0035591,GO:0035612,GO:0035615,GO:0042632,GO:0042982,GO:0043393,GO:0048260,GO:0050750,GO:0055037,GO:0061024,GO:0090118,GO:0090205,GO:1903076,GO:1905602 amyloid-beta binding|phosphotyrosine residue binding|phosphatidylinositol-4,5-bisphosphate binding|early endosome|cytosol|neurofilament|plasma membrane|receptor-mediated endocytosis|cholesterol metabolic process|cytoplasmic side of plasma membrane|basal plasma membrane|receptor signaling complex scaffold activity|clathrin binding|cholesterol transport|axon|clathrin-coated vesicle membrane|receptor internalization|low-density lipoprotein particle clearance|signaling adaptor activity|AP-2 adaptor complex binding|clathrin adaptor activity|cholesterol homeostasis|amyloid precursor protein metabolic process|regulation of protein binding|positive regulation of receptor-mediated endocytosis|low-density lipoprotein particle receptor binding|recycling endosome|membrane organization|receptor-mediated endocytosis involved in cholesterol transport|positive regulation of cholesterol metabolic process|regulation of protein localization to plasma membrane|positive regulation of receptor-mediated endocytosis involved in cholesterol transport hsa04144,hsa04979 Endocytosis|Cholesterol metabolism LDOC1 3089.03723439944 2804.04165940792 3374.03280939096 1.20327485081067 0.266966219081793 0.0511841133368771 0.82804521131659 100.677 100.097 127.777 119.197 GeneID:23641,Genbank:NM_012317.3,HGNC:HGNC:6548,MIM:300402 LDOC1, regulator of NFKB signaling GO:0005634 nucleus LEAP2 8.33877073231299 10.3777433353665 6.29979812925943 0.607048943655236 -0.720115255635236 0.516147426857498 1 0.619053 0.220168 0.369078 0.343769 GeneID:116842,Genbank:NM_052971.2,HGNC:HGNC:29571,MIM:611373 liver enriched antimicrobial peptide 2 GO:0005576,GO:0019730,GO:0042742,GO:0050832,GO:0061844 extracellular region|antimicrobial humoral response|defense response to bacterium|defense response to fungus|antimicrobial humoral immune response mediated by antimicrobial peptide LEF1 158.834382173806 152.870817443664 164.797946903949 1.07802096999109 0.108385242105166 0.69381362354327 1 1.14587 1.35475 1.60253 1.11218 GeneID:51176,Genbank:NM_001130714.2,HGNC:HGNC:6551,MIM:153245 lymphoid enhancer binding factor 1 GO:0000122,GO:0000977,GO:0000978,GO:0001077,GO:0001228,GO:0001569,GO:0001649,GO:0001755,GO:0001756,GO:0001837,GO:0002040,GO:0003677,GO:0003682,GO:0003700,GO:0003705,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006366,GO:0007223,GO:0008013,GO:0008284,GO:0008301,GO:0010628,GO:0010718,GO:0016055,GO:0016202,GO:0021542,GO:0021854,GO:0021861,GO:0021873,GO:0021879,GO:0021943,GO:0022407,GO:0022408,GO:0022409,GO:0030223,GO:0030284,GO:0030307,GO:0030326,GO:0030331,GO:0030335,GO:0030509,GO:0030854,GO:0030879,GO:0032696,GO:0032713,GO:0032714,GO:0032993,GO:0033153,GO:0035326,GO:0042100,GO:0042393,GO:0042475,GO:0042826,GO:0043027,GO:0043066,GO:0043154,GO:0043392,GO:0043565,GO:0043586,GO:0043923,GO:0043966,GO:0043967,GO:0044212,GO:0045063,GO:0045295,GO:0045843,GO:0045892,GO:0045893,GO:0045944,GO:0046632,GO:0048069,GO:0048341,GO:0048747,GO:0050909,GO:0060021,GO:0060033,GO:0060070,GO:0060325,GO:0060326,GO:0060561,GO:0060710,GO:0061153,GO:0070016,GO:0070742,GO:0071345,GO:0071353,GO:0071864,GO:0071866,GO:0071895,GO:0071899,GO:0090068,GO:0090090,GO:1902262,GO:1904837,GO:1990907 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|branching involved in blood vessel morphogenesis|osteoblast differentiation|neural crest cell migration|somitogenesis|epithelial to mesenchymal transition|sprouting angiogenesis|DNA binding|chromatin binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|nucleoplasm|transcription factor complex|cytoplasm|transcription from RNA polymerase II promoter|Wnt signaling pathway, calcium modulating pathway|beta-catenin binding|positive regulation of cell proliferation|DNA binding, bending|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|Wnt signaling pathway|regulation of striated muscle tissue development|dentate gyrus development|hypothalamus development|forebrain radial glial cell differentiation|forebrain neuroblast division|forebrain neuron differentiation|formation of radial glial scaffolds|regulation of cell-cell adhesion|negative regulation of cell-cell adhesion|positive regulation of cell-cell adhesion|neutrophil differentiation|estrogen receptor activity|positive regulation of cell growth|embryonic limb morphogenesis|estrogen receptor binding|positive regulation of cell migration|BMP signaling pathway|positive regulation of granulocyte differentiation|mammary gland development|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|protein-DNA complex|T cell receptor V(D)J recombination|enhancer binding|B cell proliferation|histone binding|odontogenesis of dentin-containing tooth|histone deacetylase binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of DNA binding|sequence-specific DNA binding|tongue development|positive regulation by host of viral transcription|histone H3 acetylation|histone H4 acetylation|transcription regulatory region DNA binding|T-helper 1 cell differentiation|gamma-catenin binding|negative regulation of striated muscle tissue development|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|alpha-beta T cell differentiation|eye pigmentation|paraxial mesoderm formation|muscle fiber development|sensory perception of taste|palate development|anatomical structure regression|canonical Wnt signaling pathway|face morphogenesis|cell chemotaxis|apoptotic process involved in morphogenesis|chorio-allantoic fusion|trachea gland development|armadillo repeat domain binding|C2H2 zinc finger domain binding|cellular response to cytokine stimulus|cellular response to interleukin-4|positive regulation of cell proliferation in bone marrow|negative regulation of apoptotic process in bone marrow|odontoblast differentiation|negative regulation of estrogen receptor binding|positive regulation of cell cycle process|negative regulation of canonical Wnt signaling pathway|apoptotic process involved in blood vessel morphogenesis|beta-catenin-TCF complex assembly|beta-catenin-TCF complex hsa04310,hsa04390,hsa04520,hsa04916,hsa04934,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412 Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Cushing syndrome|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy (ARVC) LEFTY1 1.21517230615302 0.490071401957362 1.94027321034868 3.95916432299286 1.98519594689495 0.683429885754535 1 0 0.036957 0.158152 0 GeneID:10637,Genbank:NM_020997.3,HGNC:HGNC:6552,MIM:603037 left-right determination factor 1 GO:0000122,GO:0003007,GO:0005125,GO:0005160,GO:0005615,GO:0007179,GO:0007368,GO:0008083,GO:0010862,GO:0016049,GO:0030509,GO:0042981,GO:0043408,GO:0048468,GO:0060395 negative regulation of transcription from RNA polymerase II promoter|heart morphogenesis|cytokine activity|transforming growth factor beta receptor binding|extracellular space|transforming growth factor beta receptor signaling pathway|determination of left/right symmetry|growth factor activity|positive regulation of pathway-restricted SMAD protein phosphorylation|cell growth|BMP signaling pathway|regulation of apoptotic process|regulation of MAPK cascade|cell development|SMAD protein signal transduction hsa04350 TGF-beta signaling pathway LEKR1 1.97048603866634 1.51824048055703 2.42273159677566 1.5957495718246 0.674234260686317 0.891305871991378 1 0.00639139 0.0124702 0.0123378 0.00575514 GeneID:389170,Genbank:XM_006713631.3,HGNC:HGNC:33765,MIM:613536 leucine, glutamate and lysine rich 1 GO:0003964,GO:0006310,GO:0009036,GO:0032197,GO:0032199,GO:0046872,GO:0090305 RNA-directed DNA polymerase activity|DNA recombination|Type II site-specific deoxyribonuclease activity|transposition, RNA-mediated|reverse transcription involved in RNA-mediated transposition|metal ion binding|nucleic acid phosphodiester bond hydrolysis LEMD1 5.0171674306173 5.18887166768327 4.84546319355132 0.933818275701299 -0.0987862711331069 1 1 0.0932737 0.0290384 0.0590432 0.0550511 GeneID:93273,Genbank:NM_001199052.1,HGNC:HGNC:18725,MIM:610480 LEM domain containing 1 GO:0016021 integral component of membrane LEMD2 3200.61711884157 3224.04433218876 3177.18990549439 0.985467189074738 -0.0211202570505423 0.869651698351113 1 13.1 13.6857 13.3536 13.1102 GeneID:221496,Genbank:NM_001348710.1,HGNC:HGNC:21244,MIM:616312 LEM domain containing 2 GO:0005637,GO:0005639,GO:0006998,GO:0016020,GO:0016021,GO:0022008,GO:0030514,GO:0031490,GO:0031965,GO:0035914,GO:0043409,GO:0051898,GO:0060914,GO:0070197,GO:0071168 nuclear inner membrane|integral component of nuclear inner membrane|nuclear envelope organization|membrane|integral component of membrane|neurogenesis|negative regulation of BMP signaling pathway|chromatin DNA binding|nuclear membrane|skeletal muscle cell differentiation|negative regulation of MAPK cascade|negative regulation of protein kinase B signaling|heart formation|meiotic attachment of telomere to nuclear envelope|protein localization to chromatin LEMD3 512.211014080132 528.142722477434 496.279305682831 0.939668927661945 -0.0897755514512558 0.617519075475494 1 4.99109 4.79915 5.01246 4.28483 GeneID:23592,Genbank:NM_014319.4,HGNC:HGNC:28887,MIM:607844 LEM domain containing 3 GO:0001525,GO:0005637,GO:0005639,GO:0006998,GO:0016020,GO:0016021,GO:0030512,GO:0030514,GO:0031490,GO:0031965,GO:0032926,GO:0070197,GO:1902531 angiogenesis|nuclear inner membrane|integral component of nuclear inner membrane|nuclear envelope organization|membrane|integral component of membrane|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|chromatin DNA binding|nuclear membrane|negative regulation of activin receptor signaling pathway|meiotic attachment of telomere to nuclear envelope|regulation of intracellular signal transduction LENEP 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.101321 0 0 0 GeneID:55891,Genbank:NM_018655.2,HGNC:HGNC:14429,MIM:607377 lens epithelial protein GO:0003677,GO:0007275 DNA binding|multicellular organism development LENG1 330.877683011419 356.957983718571 304.797382304267 0.853874674910121 -0.227903757071643 0.263758393462638 1 11.3065 12.7763 9.67782 11.0729 GeneID:79165,Genbank:NM_024316.2,HGNC:HGNC:15502 leukocyte receptor cluster member 1 LENG8 1746.71384763375 1728.79731725588 1764.63037801162 1.02072716124561 0.0295972876450458 0.856442571311559 1 8.92921 9.31911 10.4218 8.89253 GeneID:114823,Genbank:XM_005278249.5,HGNC:HGNC:15500,MIM:616575 leukocyte receptor cluster member 8 LENG9 96.8761399639029 91.0169765934129 102.735303334393 1.12874880247151 0.174724457102082 0.564606731882744 1 2.4328 2.16695 2.33252 2.7347 GeneID:94059,Genbank:NM_001301782.1,HGNC:HGNC:16306 leukocyte receptor cluster member 9 GO:0046872 metal ion binding LEO1 400.178007179284 409.74939095931 390.606623399259 0.953281766898462 -0.0690253921636087 0.72716900114738 1 3.85969 3.59948 3.722 3.53128 GeneID:123169,Genbank:XM_017021911.1,HGNC:HGNC:30401,MIM:610507 LEO1 homolog, Paf1/RNA polymerase II complex component GO:0001711,GO:0006368,GO:0006378,GO:0016055,GO:0016570,GO:0016593,GO:0019827,GO:0031442,GO:0032968,GO:0045638,GO:0045944 endodermal cell fate commitment|transcription elongation from RNA polymerase II promoter|mRNA polyadenylation|Wnt signaling pathway|histone modification|Cdc73/Paf1 complex|stem cell population maintenance|positive regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|negative regulation of myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter LEPR 101.953612049769 97.2722349592729 106.634989140265 1.09625310022857 0.132580922649995 0.698534318765651 1 0.622448 0.425942 0.686954 0.500043 GeneID:3953,Genbank:NM_002303.5,HGNC:HGNC:6554,MIM:601007 leptin receptor GO:0001525,GO:0004888,GO:0005576,GO:0005886,GO:0006112,GO:0006909,GO:0007166,GO:0007275,GO:0008203,GO:0010507,GO:0016021,GO:0016323,GO:0019953,GO:0030217,GO:0033210,GO:0038021,GO:0042593,GO:0042802,GO:0043235,GO:0044321,GO:0045721,GO:0046850,GO:0051346,GO:0060259,GO:0097009,GO:0098868,GO:2000505 angiogenesis|transmembrane signaling receptor activity|extracellular region|plasma membrane|energy reserve metabolic process|phagocytosis|cell surface receptor signaling pathway|multicellular organism development|cholesterol metabolic process|negative regulation of autophagy|integral component of membrane|basolateral plasma membrane|sexual reproduction|T cell differentiation|leptin-mediated signaling pathway|leptin receptor activity|glucose homeostasis|identical protein binding|receptor complex|response to leptin|negative regulation of gluconeogenesis|regulation of bone remodeling|negative regulation of hydrolase activity|regulation of feeding behavior|energy homeostasis|bone growth|regulation of energy homeostasis hsa04060,hsa04080,hsa04152,hsa04630,hsa04920,hsa04932 Cytokine-cytokine receptor interaction|Neuroactive ligand-receptor interaction|AMPK signaling pathway|Jak-STAT signaling pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease (NAFLD) LEPROT 1152.1026902907 1095.43332218166 1208.77205839974 1.10346475127519 0.142040545364973 0.342311955969314 1 10.896 11.3273 13.8287 10.8151 GeneID:54741,Genbank:NM_017526.4,HGNC:HGNC:29477,MIM:613461 leptin receptor overlapping transcript GO:0000139,GO:0005102,GO:0005768,GO:0005794,GO:0010008,GO:0016021,GO:0032511,GO:0046426,GO:0060400,GO:1903955,GO:2000009 Golgi membrane|receptor binding|endosome|Golgi apparatus|endosome membrane|integral component of membrane|late endosome to vacuole transport via multivesicular body sorting pathway|negative regulation of JAK-STAT cascade|negative regulation of growth hormone receptor signaling pathway|positive regulation of protein targeting to mitochondrion|negative regulation of protein localization to cell surface LEPROTL1 2186.92680313046 2246.79058511455 2127.06302114636 0.946711738618896 -0.0790028841594536 0.580382487503523 1 39.7901 39.9949 39.4317 36.244 GeneID:23484,Genbank:NM_001128208.1,HGNC:HGNC:6555,MIM:607338 leptin receptor overlapping transcript like 1 GO:0005768,GO:0016021,GO:0032511,GO:2000009 endosome|integral component of membrane|late endosome to vacuole transport via multivesicular body sorting pathway|negative regulation of protein localization to cell surface LETM1 1932.13092148397 1936.92951626028 1927.33232670766 0.995045152922677 -0.00716610147267584 0.946092637638943 1 14.8991 15.5471 15.5419 15.1931 GeneID:3954,Genbank:NM_012318.2,HGNC:HGNC:6556,MIM:604407 leucine zipper and EF-hand containing transmembrane protein 1 GO:0005509,GO:0005739,GO:0005743,GO:0006851,GO:0006875,GO:0015369,GO:0016021,GO:0034214,GO:0042407,GO:0043022,GO:0051260,GO:0051560,GO:0099093 calcium ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|cellular metal ion homeostasis|calcium:proton antiporter activity|integral component of membrane|protein hexamerization|cristae formation|ribosome binding|protein homooligomerization|mitochondrial calcium ion homeostasis|mitochondrial calcium release LETM2 55.7285676795283 52.3405704592131 59.1165648998435 1.12945969792039 0.175632792512545 0.663938965040893 1 0.224868 0.197986 0.180152 0.238029 GeneID:137994,Genbank:XM_017013056.1,HGNC:HGNC:14648 leucine zipper and EF-hand containing transmembrane protein 2 GO:0005743,GO:0006875,GO:0016021,GO:0043022 mitochondrial inner membrane|cellular metal ion homeostasis|integral component of membrane|ribosome binding LETMD1 515.294697256043 466.453594762309 564.135799749777 1.20941462577268 0.274308931102368 0.121616065122858 1 2.31214 2.67647 3.47652 2.87737 GeneID:25875,Genbank:NM_001351337.1,HGNC:HGNC:24241 LETM1 domain containing 1 GO:0005654,GO:0005739,GO:0005741,GO:0005743,GO:0006875,GO:0016021,GO:0043022 nucleoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|cellular metal ion homeostasis|integral component of membrane|ribosome binding LFNG 165.882190240128 214.503127229851 117.261253250406 0.546664539416037 -0.871272299865429 0.00037855468812305 0.0531836130261296 3.56643 3.44602 1.6955 2.3682 GeneID:3955,Genbank:NM_001166355.1,HGNC:HGNC:6560,MIM:602576 LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase hsa00514,hsa04330,hsa05165 Other types of O-glycan biosynthesis|Notch signaling pathway|Human papillomavirus infection LGALS1 19888.0780999938 20102.7761298521 19673.3800701354 0.978639962115529 -0.0311498994158504 0.882794273296804 1 2025.31 2211.95 1742.91 2260.53 GeneID:3956,Genbank:NM_002305.3,HGNC:HGNC:6561,MIM:150570 galectin 1 LGALS12 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0 0 0.0397911 0.0186078 GeneID:85329,Genbank:NM_001142535.1,HGNC:HGNC:15788,MIM:606096 galectin 12 LGALS2 1.48922424384437 2.00831188251439 0.97013660517434 0.483060730567275 -1.04972351828911 0.81262307337585 1 0 0 0 0 GeneID:3957,Genbank:NM_006498.2,HGNC:HGNC:6562,MIM:150571 galectin 2 LGALS3 1743.53235649204 1474.61700677684 2012.44770620725 1.36472568603151 0.448610994241875 0.0381670217781498 0.746377314772707 51.8294 53.2532 65.2318 78.4713 GeneID:3958,Genbank:NM_001357678.1,HGNC:HGNC:6563,MIM:153619 galectin 3 LGALS3BP 17051.1096978361 16101.6835189154 18000.5358767569 1.11792880884852 0.160828318421364 0.24102516199432 1 277.209 285.059 357.382 286.849 GeneID:3959,Genbank:NM_005567.3,HGNC:HGNC:6564,MIM:600626 galectin 3 binding protein GO:0002576,GO:0005044,GO:0005576,GO:0005578,GO:0005615,GO:0006968,GO:0007155,GO:0007165,GO:0016020,GO:0031012,GO:0031089,GO:0070062,GO:0072562 platelet degranulation|scavenger receptor activity|extracellular region|proteinaceous extracellular matrix|extracellular space|cellular defense response|cell adhesion|signal transduction|membrane|extracellular matrix|platelet dense granule lumen|extracellular exosome|blood microparticle LGALS4 0.729234031512454 0.490071401957362 0.968396661067546 1.97603177251261 0.982606144127986 1 1 0 0 0 0.0216884 GeneID:3960,Genbank:XM_011526974.2,HGNC:HGNC:6565,MIM:602518 galectin 4 LGALS7B 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.497626 0 0 GeneID:653499,Genbank:NM_001042507.3,HGNC:HGNC:34447,MIM:617139 galectin 7B LGALS8 595.505675308778 619.582126887903 571.429223729653 0.922281645856833 -0.116720707538228 0.50640332977431 1 2.15132 1.93123 2.10252 1.60808 GeneID:3964,Genbank:NM_201545.2,HGNC:HGNC:6569,MIM:606099 galectin 8 LGALS9 76.4205621184065 44.701341781743 108.13978245507 2.41916188966025 1.27450731731083 0.402504001814439 1 0.444231 0.435376 1.796 0.304534 GeneID:3965,Genbank:NM_009587.2,HGNC:HGNC:6570,MIM:601879 galectin 9 LGALS9B 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:284194,Genbank:NM_001042685.1,HGNC:HGNC:24842 galectin 9B GO:0005829,GO:0030246 cytosol|carbohydrate binding LGALS9C 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0268732 0 0 0 GeneID:654346,Genbank:NM_001040078.2,HGNC:HGNC:33874 galectin 9C GO:0005829,GO:0030246 cytosol|carbohydrate binding LGALSL 151.694592284252 146.355810394163 157.03337417434 1.0729562000403 0.101591183946819 0.708154979878256 1 1.55754 1.8194 2.04572 1.63631 GeneID:29094,Genbank:NM_014181.2,HGNC:HGNC:25012 galectin like GO:0005622,GO:0030246 intracellular|carbohydrate binding LGI1 36.3268709275492 34.3716247210614 38.282117134037 1.11377095044854 0.15545256963625 0.766283238076514 1 0.357175 0.510839 0.529526 0.479359 GeneID:9211,Genbank:NM_005097.3,HGNC:HGNC:6572,MIM:604619 leucine rich glioma inactivated 1 LGI2 21.3663820534452 36.9180342802181 5.81472982667226 0.157503776678272 -2.66654167243551 7.15916145157801e-05 0.0194340897980463 0.140718 0.146861 0.0186134 0.0303244 GeneID:55203,Genbank:XM_017008356.1,HGNC:HGNC:18710,MIM:608301 leucine rich repeat LGI family member 2 GO:0005576,GO:0005615 extracellular region|extracellular space LGI3 7.4904397579578 10.6178747087913 4.36300480712434 0.410911310105393 -1.28310105445626 0.491756834042263 1 0.294871 0.0297313 0.0960881 0.0299494 GeneID:203190,Genbank:NM_139278.2,HGNC:HGNC:18711,MIM:608302 leucine rich repeat LGI family member 3 GO:0003824,GO:0005576,GO:0006887,GO:0008021,GO:0017157,GO:0030054,GO:0043005 catalytic activity|extracellular region|exocytosis|synaptic vesicle|regulation of exocytosis|cell junction|neuron projection LGI4 1.94397135163878 0.980142803914724 2.90779989936283 2.96671045050678 1.5688641273566 0.614282413029316 1 0 0.0248306 0.0391364 0.0366187 GeneID:163175,Genbank:NM_139284.2,HGNC:HGNC:18712,MIM:608303 leucine rich repeat LGI family member 4 GO:0005576,GO:0005615,GO:0008344,GO:0014009,GO:0022011,GO:0031641,GO:0042551 extracellular region|extracellular space|adult locomotory behavior|glial cell proliferation|myelination in peripheral nervous system|regulation of myelination|neuron maturation LGMN 768.247748806377 774.202524531296 762.292973081459 0.984617007730572 -0.0223654347817423 0.889453875842968 1 10.4101 9.64781 9.72113 10.6664 GeneID:5641,Genbank:NM_005606.6,HGNC:HGNC:9472,MIM:602620 legumain GO:0002224,GO:0003014,GO:0004197,GO:0005764,GO:0005770,GO:0006508,GO:0006624,GO:0008233,GO:0010447,GO:0019886,GO:0032801,GO:0036021,GO:0040015,GO:0042359,GO:0043202,GO:0043524,GO:0045177,GO:0051603,GO:0070062,GO:1901185 toll-like receptor signaling pathway|renal system process|cysteine-type endopeptidase activity|lysosome|late endosome|proteolysis|vacuolar protein processing|peptidase activity|response to acidic pH|antigen processing and presentation of exogenous peptide antigen via MHC class II|receptor catabolic process|endolysosome lumen|negative regulation of multicellular organism growth|vitamin D metabolic process|lysosomal lumen|negative regulation of neuron apoptotic process|apical part of cell|proteolysis involved in cellular protein catabolic process|extracellular exosome|negative regulation of ERBB signaling pathway hsa04142,hsa04612 Lysosome|Antigen processing and presentation LGR4 1153.5808189305 1112.911179517 1194.250458344 1.07308694559281 0.101766973479143 0.555682857308359 1 11.1966 10.5815 13.6266 10.1544 GeneID:55366,Genbank:NM_001346432.1,HGNC:HGNC:13299,MIM:606666 leucine rich repeat containing G protein-coupled receptor 4 GO:0001649,GO:0001942,GO:0004888,GO:0004930,GO:0005886,GO:0005887,GO:0007283,GO:0016500,GO:0030282,GO:0030539,GO:0032922,GO:0034122,GO:0036335,GO:0045087,GO:0045892,GO:0045893,GO:0046849,GO:0048565,GO:0050710,GO:0061290,GO:0072202,GO:0072224,GO:0072282,GO:0090190,GO:0090263,GO:2001013 osteoblast differentiation|hair follicle development|transmembrane signaling receptor activity|G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|spermatogenesis|protein-hormone receptor activity|bone mineralization|male genitalia development|circadian regulation of gene expression|negative regulation of toll-like receptor signaling pathway|intestinal stem cell homeostasis|innate immune response|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|bone remodeling|digestive tract development|negative regulation of cytokine secretion|canonical Wnt signaling pathway involved in metanephric kidney development|cell differentiation involved in metanephros development|metanephric glomerulus development|metanephric nephron tubule morphogenesis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt signaling pathway|epithelial cell proliferation involved in renal tubule morphogenesis LGR5 31.1450121811986 45.3256833526473 16.96434100975 0.374276563637494 -1.41782338216256 0.060893764404047 0.88260138524454 0.589133 0.300052 0.20901 0.136455 GeneID:8549,Genbank:NM_003667.3,HGNC:HGNC:4504,MIM:606667 leucine rich repeat containing G protein-coupled receptor 5 GO:0001942,GO:0004888,GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0009994,GO:0016500,GO:0032588,GO:0042127,GO:0048839,GO:0090263,GO:2001013 hair follicle development|transmembrane signaling receptor activity|G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|oocyte differentiation|protein-hormone receptor activity|trans-Golgi network membrane|regulation of cell proliferation|inner ear development|positive regulation of canonical Wnt signaling pathway|epithelial cell proliferation involved in renal tubule morphogenesis LGR6 31.5913684501536 31.6811363378499 31.5016005624573 0.994333038642365 -0.00819895062020082 1 1 0.139059 0.111605 0.123625 0.153985 GeneID:59352,Genbank:NM_001017403.1,HGNC:HGNC:19719,MIM:606653 leucine rich repeat containing G protein-coupled receptor 6 GO:0004888,GO:0005886,GO:0005887,GO:0007186,GO:0016055,GO:0016500,GO:0030177,GO:0030335,GO:0031982,GO:0032588,GO:0090263,GO:1990523 transmembrane signaling receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|Wnt signaling pathway|protein-hormone receptor activity|positive regulation of Wnt signaling pathway|positive regulation of cell migration|vesicle|trans-Golgi network membrane|positive regulation of canonical Wnt signaling pathway|bone regeneration LGSN 2.45762090491191 2.00831188251439 2.90692992730943 1.44744944877286 0.533512963911774 0.908782745802202 1 0.00435658 0.00840378 0.00420761 0.0156456 GeneID:51557,Genbank:NM_001143940.1,HGNC:HGNC:21016,MIM:611470 lengsin, lens protein with glutamine synthetase domain GO:0004356,GO:0005886,GO:0006542 glutamate-ammonia ligase activity|plasma membrane|glutamine biosynthetic process LHB 10.0915928228868 7.10113100082778 13.0820546449458 1.84224944497163 0.881468419007217 0.359911807861037 1 0.138199 0.347427 0.763104 0.941506 GeneID:3972,Genbank:NM_000894.2,HGNC:HGNC:6584,MIM:152780 luteinizing hormone beta polypeptide hsa04080,hsa04912,hsa04913,hsa04917 Neuroactive ligand-receptor interaction|GnRH signaling pathway|Ovarian steroidogenesis|Prolactin signaling pathway LHCGR 1.97842567374833 2.98845468642911 0.968396661067546 0.32404595775373 -1.62572965732849 0.555377186137041 1 0.00616392 0.0178836 0 0.0110915 GeneID:3973,Genbank:NM_000233.3,HGNC:HGNC:6585,MIM:152790 luteinizing hormone/choriogonadotropin receptor hsa04020,hsa04080,hsa04913,hsa04917 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Ovarian steroidogenesis|Prolactin signaling pathway LHFPL1 8.36071730599706 9.93569820809413 6.7857364039 0.682965229194662 -0.550115964315426 0.644808529849046 1 0.110842 0.0688166 0.0351805 0.065631 GeneID:340596,Genbank:NM_178175.3,HGNC:HGNC:6587,MIM:300566 LHFPL tetraspan subfamily member 1 GO:0016021 integral component of membrane LHFPL2 1530.63773782242 1600.46625352795 1460.8092221169 0.912739783732896 -0.13172447917612 0.365343083055811 1 8.17579 8.24559 8.59927 6.62361 GeneID:10184,Genbank:NM_005779.2,HGNC:HGNC:6588,MIM:609718 LHFPL tetraspan subfamily member 2 GO:0002576,GO:0005886,GO:0007338,GO:0016021,GO:0031092,GO:0046545,GO:0046546,GO:1905516 platelet degranulation|plasma membrane|single fertilization|integral component of membrane|platelet alpha granule membrane|development of primary female sexual characteristics|development of primary male sexual characteristics|positive regulation of fertilization LHFPL3 2.93855608018229 1.02816907859967 4.84894308176491 4.71609503017637 2.23759278917919 0.285607703241725 1 0.0135772 0.0131227 0.104904 0.0243719 GeneID:375612,Genbank:NM_199000.2,HGNC:HGNC:6589,MIM:609719 LHFPL tetraspan subfamily member 3 GO:0016021 integral component of membrane LHFPL4 45.3344371285445 37.3600794074905 53.3087948495985 1.42689190427444 0.512876046044156 0.233847839429441 1 0.19233 0.220907 0.309314 0.283314 GeneID:375323,Genbank:NM_198560.2,HGNC:HGNC:29568,MIM:610240 LHFPL tetraspan subfamily member 4 GO:0016021 integral component of membrane LHFPL6 1140.41879339718 1022.15395160723 1258.68363518712 1.23140318853924 0.300303209319193 0.0432152761773562 0.777680745232064 17.4243 16.4051 23.6197 18.817 GeneID:10186,Genbank:NM_005780.2,HGNC:HGNC:6586,MIM:606710 LHFPL tetraspan subfamily member 6 LHPP 138.616587046331 126.042368850702 151.190805241959 1.19952367303605 0.262461630023762 0.332578288810832 1 0.590905 0.631041 0.721204 0.82893 GeneID:64077,Genbank:NM_022126.3,HGNC:HGNC:30042,MIM:617231 phospholysine phosphohistidine inorganic pyrophosphate phosphatase GO:0000287,GO:0004427,GO:0005634,GO:0005829,GO:0006470,GO:0006796,GO:0009168,GO:0016311,GO:0016607,GO:0016791,GO:0042803,GO:0101006 magnesium ion binding|inorganic diphosphatase activity|nucleus|cytosol|protein dephosphorylation|phosphate-containing compound metabolic process|purine ribonucleoside monophosphate biosynthetic process|dephosphorylation|nuclear speck|phosphatase activity|protein homodimerization activity|protein histidine phosphatase activity hsa00190 Oxidative phosphorylation LHX1 81.5671923692597 100.606682223605 62.5277025149149 0.621506455962271 -0.68615871738856 0.0371072507448128 0.744556882325193 1.56339 1.10352 0.948411 0.597799 GeneID:3975,Genbank:NM_005568.4,HGNC:HGNC:6593,MIM:601999 LIM homeobox 1 GO:0001655,GO:0001657,GO:0001658,GO:0001702,GO:0001705,GO:0001706,GO:0001822,GO:0003700,GO:0003714,GO:0005634,GO:0006366,GO:0007267,GO:0007389,GO:0007399,GO:0008045,GO:0009653,GO:0009791,GO:0009880,GO:0009887,GO:0009948,GO:0009952,GO:0009953,GO:0010468,GO:0010842,GO:0021517,GO:0021527,GO:0021537,GO:0021549,GO:0021702,GO:0021871,GO:0021937,GO:0032525,GO:0035502,GO:0035846,GO:0035847,GO:0035849,GO:0035852,GO:0040019,GO:0043234,GO:0043565,GO:0044344,GO:0045892,GO:0045893,GO:0046872,GO:0048646,GO:0048703,GO:0048793,GO:0060059,GO:0060065,GO:0060066,GO:0060067,GO:0060068,GO:0060322,GO:0060429,GO:0061205,GO:0072049,GO:0072050,GO:0072077,GO:0072177,GO:0072178,GO:0072224,GO:0072278,GO:0072283,GO:0072284,GO:0090009,GO:0090190,GO:0097379,GO:0097477,GO:2000543,GO:2000744,GO:2000768 urogenital system development|ureteric bud development|branching involved in ureteric bud morphogenesis|gastrulation with mouth forming second|ectoderm formation|endoderm formation|kidney development|DNA binding transcription factor activity|transcription corepressor activity|nucleus|transcription from RNA polymerase II promoter|cell-cell signaling|pattern specification process|nervous system development|motor neuron axon guidance|anatomical structure morphogenesis|post-embryonic development|embryonic pattern specification|animal organ morphogenesis|anterior/posterior axis specification|anterior/posterior pattern specification|dorsal/ventral pattern formation|regulation of gene expression|retina layer formation|ventral spinal cord development|spinal cord association neuron differentiation|telencephalon development|cerebellum development|cerebellar Purkinje cell differentiation|forebrain regionalization|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|somite rostral/caudal axis specification|metanephric part of ureteric bud development|oviduct epithelium development|uterine epithelium development|nephric duct elongation|horizontal cell localization|positive regulation of embryonic development|protein complex|sequence-specific DNA binding|cellular response to fibroblast growth factor stimulus|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|anatomical structure formation involved in morphogenesis|embryonic viscerocranium morphogenesis|pronephros development|embryonic retina morphogenesis in camera-type eye|uterus development|oviduct development|cervix development|vagina development|head development|epithelium development|paramesonephric duct development|comma-shaped body morphogenesis|S-shaped body morphogenesis|renal vesicle morphogenesis|mesonephric duct development|nephric duct morphogenesis|metanephric glomerulus development|metanephric comma-shaped body morphogenesis|metanephric renal vesicle morphogenesis|metanephric S-shaped body morphogenesis|primitive streak formation|positive regulation of branching involved in ureteric bud morphogenesis|dorsal spinal cord interneuron posterior axon guidance|lateral motor column neuron migration|positive regulation of gastrulation|positive regulation of anterior head development|positive regulation of nephron tubule epithelial cell differentiation LHX2 90.1684373161238 96.4940059092059 83.8428687230417 0.868891989020872 -0.202751246488517 0.542642601016595 1 2.30836 1.29211 1.84916 1.54686 GeneID:9355,Genbank:NM_004789.3,HGNC:HGNC:6594,MIM:603759 LIM homeobox 2 GO:0000978,GO:0001076,GO:0001077,GO:0001843,GO:0001942,GO:0003682,GO:0005634,GO:0007411,GO:0007498,GO:0009953,GO:0021772,GO:0021978,GO:0021987,GO:0045199,GO:0045893,GO:0046872,GO:0048675,GO:0060041,GO:2000678 RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|neural tube closure|hair follicle development|chromatin binding|nucleus|axon guidance|mesoderm development|dorsal/ventral pattern formation|olfactory bulb development|telencephalon regionalization|cerebral cortex development|maintenance of epithelial cell apical/basal polarity|positive regulation of transcription, DNA-templated|metal ion binding|axon extension|retina development in camera-type eye|negative regulation of transcription regulatory region DNA binding LHX3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0163457 GeneID:8022,Genbank:NM_178138.5,HGNC:HGNC:6595,MIM:600577 LIM homeobox 3 GO:0000978,GO:0001076,GO:0001077,GO:0001085,GO:0001228,GO:0001890,GO:0005634,GO:0005667,GO:0008045,GO:0009887,GO:0021520,GO:0021521,GO:0021526,GO:0021527,GO:0021983,GO:0030324,GO:0043066,GO:0043565,GO:0045893,GO:0045944,GO:0046872,GO:0048839 RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|placenta development|nucleus|transcription factor complex|motor neuron axon guidance|animal organ morphogenesis|spinal cord motor neuron cell fate specification|ventral spinal cord interneuron specification|medial motor column neuron differentiation|spinal cord association neuron differentiation|pituitary gland development|lung development|negative regulation of apoptotic process|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|inner ear development LHX4 24.1485328870489 26.0021932682093 22.2948725058885 0.85742276722274 -0.221921369214569 0.716107149318158 1 0.113741 0.165997 0.136386 0.106081 GeneID:89884,Genbank:XM_011510105.2,HGNC:HGNC:21734,MIM:602146 LIM homeobox 4 GO:0001228,GO:0001890,GO:0005634,GO:0008045,GO:0009887,GO:0021526,GO:0043066,GO:0043565,GO:0045944,GO:0046872 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|placenta development|nucleus|motor neuron axon guidance|animal organ morphogenesis|medial motor column neuron differentiation|negative regulation of apoptotic process|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding LHX6 8.44111843293835 6.7071121482403 10.1751247176364 1.51706494430781 0.601282847500096 0.578308787039997 1 0.0652872 0.0498393 0.0349072 0.0978501 GeneID:26468,Genbank:XM_011518521.2,HGNC:HGNC:21735,MIM:608215 LIM homeobox 6 GO:0003700,GO:0005634,GO:0006351,GO:0021799,GO:0021800,GO:0021853,GO:0043565,GO:0046872,GO:0048469 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration|cerebral cortex GABAergic interneuron migration|sequence-specific DNA binding|metal ion binding|cell maturation LHX9 9.19741050398017 7.24520982488261 11.1496111830777 1.53889417319372 0.621894023701143 0.538540962923783 1 0.0357475 0.034478 0.0804112 0.0427436 GeneID:56956,Genbank:NM_001014434.1,HGNC:HGNC:14222,MIM:606066 LIM homeobox 9 GO:0003714,GO:0005634,GO:0008283,GO:0008584,GO:0008585,GO:0035262,GO:0043565,GO:0045892,GO:0046872,GO:0097380 transcription corepressor activity|nucleus|cell proliferation|male gonad development|female gonad development|gonad morphogenesis|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|dorsal spinal cord interneuron anterior axon guidance LIAS 240.007122224578 254.649747569923 225.364496879233 0.884997919808862 -0.176254030748186 0.41800454781985 1 4.09574 4.18646 3.88693 3.46356 GeneID:11019,Genbank:XM_017007666.1,HGNC:HGNC:16429,MIM:607031 lipoic acid synthetase GO:0001843,GO:0005739,GO:0005759,GO:0006954,GO:0006979,GO:0009107,GO:0009249,GO:0016992,GO:0032496,GO:0034641,GO:0046872,GO:0051539 neural tube closure|mitochondrion|mitochondrial matrix|inflammatory response|response to oxidative stress|lipoate biosynthetic process|protein lipoylation|lipoate synthase activity|response to lipopolysaccharide|cellular nitrogen compound metabolic process|metal ion binding|4 iron, 4 sulfur cluster binding hsa00785 Lipoic acid metabolism LIF 1839.28625778822 2137.44987855083 1541.1226370256 0.721009953258165 -0.471908919447504 0.000884727113224244 0.0944652629693299 20.5466 19.6215 14.9218 14.2969 GeneID:3976,Genbank:NM_001257135.1,HGNC:HGNC:6596,MIM:159540 LIF, interleukin 6 family cytokine hsa04060,hsa04550,hsa04630,hsa04668 Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells|Jak-STAT signaling pathway|TNF signaling pathway LIFR 124.715405883999 133.094456575991 116.336355192008 0.874088659925411 -0.19414847334513 0.757366201200415 1 0.577649 0.339984 0.510846 0.292212 GeneID:3977,Genbank:NM_002310.5,HGNC:HGNC:6597,MIM:151443 LIF receptor alpha hsa04060,hsa04550,hsa04630 Cytokine-cytokine receptor interaction|Signaling pathways regulating pluripotency of stem cells|Jak-STAT signaling pathway LIG1 1646.895680197 1675.64030012702 1618.15106026698 0.965691180943979 -0.0503661925255998 0.704729966392365 1 13.4367 15.0439 14.0432 13.8773 GeneID:3978,Genbank:NM_001289063.1,HGNC:HGNC:6598,MIM:126391 DNA ligase 1 hsa03030,hsa03410,hsa03420,hsa03430 DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair LIG3 1058.76238669236 1125.99023689154 991.534536493176 0.880588928755233 -0.183459388848223 0.226071390693242 1 5.91375 6.01395 5.27681 5.28046 GeneID:3980,Genbank:NM_013975.3,HGNC:HGNC:6600,MIM:600940 DNA ligase 3 hsa03410 Base excision repair LIG4 116.747906481224 136.054502297951 97.441310664497 0.716193209476499 -0.48157925495138 0.298368064712182 1 0.892836 0.803582 0.86917 0.389055 GeneID:3981,Genbank:NM_001098268.1,HGNC:HGNC:6601,MIM:601837 DNA ligase 4 hsa03450 Non-homologous end-joining LILRA2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0134951 GeneID:11027,Genbank:XM_006722986.1,HGNC:HGNC:6603,MIM:604812 leukocyte immunoglobulin like receptor A2 GO:0001791,GO:0002220,GO:0002283,GO:0003823,GO:0004872,GO:0005576,GO:0005887,GO:0006952,GO:0007165,GO:0031665,GO:0032604,GO:0032635,GO:0032637,GO:0034144,GO:0045087,GO:0071611 IgM binding|innate immune response activating cell surface receptor signaling pathway|neutrophil activation involved in immune response|antigen binding|receptor activity|extracellular region|integral component of plasma membrane|defense response|signal transduction|negative regulation of lipopolysaccharide-mediated signaling pathway|granulocyte macrophage colony-stimulating factor production|interleukin-6 production|interleukin-8 production|negative regulation of toll-like receptor 4 signaling pathway|innate immune response|granulocyte colony-stimulating factor production hsa04380 Osteoclast differentiation LIM2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0526288 GeneID:3982,Genbank:NM_001161748.1,HGNC:HGNC:6610,MIM:154045 lens intrinsic membrane protein 2 GO:0002088,GO:0005212,GO:0005886,GO:0007043,GO:0016021,GO:0030054,GO:0031982 lens development in camera-type eye|structural constituent of eye lens|plasma membrane|cell-cell junction assembly|integral component of membrane|cell junction|vesicle LIMA1 2148.76896451449 2214.35861169025 2083.17931733874 0.940759688309302 -0.0881018530828454 0.660897585447975 1 14.2086 13.4008 15.0391 11.208 GeneID:51474,Genbank:NM_016357.4,HGNC:HGNC:24636,MIM:608364 LIM domain and actin binding 1 GO:0001725,GO:0003785,GO:0005829,GO:0005886,GO:0005903,GO:0005925,GO:0015629,GO:0030835,GO:0031529,GO:0032154,GO:0045296,GO:0046872,GO:0051015,GO:0051017 stress fiber|actin monomer binding|cytosol|plasma membrane|brush border|focal adhesion|actin cytoskeleton|negative regulation of actin filament depolymerization|ruffle organization|cleavage furrow|cadherin binding|metal ion binding|actin filament binding|actin filament bundle assembly LIMCH1 2857.51598696407 2827.84815934571 2887.18381458242 1.02098261713261 0.0299583036397505 0.830837059104333 1 9.27738 8.10915 9.97084 7.66434 GeneID:22998,Genbank:NM_001289124.1,HGNC:HGNC:29191,MIM:617750 LIM and calponin homology domains 1 GO:0003779,GO:0031032,GO:0046872 actin binding|actomyosin structure organization|metal ion binding LIMD1 1031.28454230065 1047.70429109306 1014.86479350824 0.968655757293353 -0.0459440458447657 0.781139652595808 1 5.32516 4.89374 5.45987 4.66722 GeneID:8994,Genbank:XM_011534207.3,HGNC:HGNC:6612,MIM:604543 LIM domains containing 1 hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species LIMD2 117.41701539198 121.929692536304 112.904338247655 0.925979028562209 -0.110948574978426 0.681175317663348 1 0.99969 1.24517 0.949968 1.05275 GeneID:80774,Genbank:NM_030576.3,HGNC:HGNC:28142 LIM domain containing 2 GO:0005634,GO:0005737,GO:0046872 nucleus|cytoplasm|metal ion binding LIME1 80.3448747543189 73.9321211098061 86.7576283988317 1.17347679325982 0.230789311328463 0.48724418964139 1 2.26705 1.63129 2.51627 1.6394 GeneID:54923,Genbank:NM_001305654.1,HGNC:HGNC:26016,MIM:609809 Lck interacting transmembrane adaptor 1 GO:0000390,GO:0002250,GO:0005615,GO:0005886,GO:0016021,GO:0050852,GO:0050853,GO:0071008 spliceosomal complex disassembly|adaptive immune response|extracellular space|plasma membrane|integral component of membrane|T cell receptor signaling pathway|B cell receptor signaling pathway|U2-type post-mRNA release spliceosomal complex LIMK1 3262.39033953866 2989.67860019697 3535.10207888035 1.18243548943604 0.241761476072519 0.0996466094361013 1 34.7504 33.4409 38.7233 43.6947 GeneID:3984,Genbank:NM_002314.3,HGNC:HGNC:6613,MIM:601329 LIM domain kinase 1 hsa04360,hsa04666,hsa04810,hsa05170 Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection LIMK2 690.667813678822 645.258961889281 736.076665468363 1.14074613285986 0.18997776304207 0.357101539296475 1 4.17878 4.54425 4.57877 5.66859 GeneID:3985,Genbank:NM_005569.3,HGNC:HGNC:6614,MIM:601988 LIM domain kinase 2 GO:0004674,GO:0004871,GO:0005524,GO:0005634,GO:0005737,GO:0005801,GO:0007283,GO:0016310,GO:0035556,GO:0046872,GO:0046982 protein serine/threonine kinase activity|signal transducer activity|ATP binding|nucleus|cytoplasm|cis-Golgi network|spermatogenesis|phosphorylation|intracellular signal transduction|metal ion binding|protein heterodimerization activity hsa04360,hsa04666,hsa04810,hsa05170 Axon guidance|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection LIMS1 1429.03208825979 1577.99838727621 1280.06578924336 0.811195879263788 -0.301877771171353 0.1597763666967 1 9.77102 8.55554 8.64236 6.13521 GeneID:3987,Genbank:XM_017004092.1,HGNC:HGNC:6616,MIM:602567 LIM zinc finger domain containing 1 GO:0005829,GO:0005886,GO:0005911,GO:0005925,GO:0007569,GO:0008270,GO:0010628,GO:0010811,GO:0019901,GO:0033209,GO:0034329,GO:0043234,GO:0043547,GO:0045184,GO:0045892,GO:0048471,GO:0051291,GO:0051894,GO:0071560,GO:1900026,GO:1901224 cytosol|plasma membrane|cell-cell junction|focal adhesion|cell aging|zinc ion binding|positive regulation of gene expression|positive regulation of cell-substrate adhesion|protein kinase binding|tumor necrosis factor-mediated signaling pathway|cell junction assembly|protein complex|positive regulation of GTPase activity|establishment of protein localization|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm|protein heterooligomerization|positive regulation of focal adhesion assembly|cellular response to transforming growth factor beta stimulus|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of NIK/NF-kappaB signaling LIMS2 7.22692446531383 5.72696934432558 8.72687958630208 1.52382159945537 0.6076940100185 0.605662066965587 1 0.0738002 0.0315594 0.135628 0.0317189 GeneID:55679,Genbank:NM_001161404.1,HGNC:HGNC:16084,MIM:607908 LIM zinc finger domain containing 2 GO:0005634,GO:0005829,GO:0005886,GO:0005925,GO:0034329,GO:0043066,GO:0045216,GO:0046872,GO:0098609,GO:2000178,GO:2000346,GO:2001046 nucleus|cytosol|plasma membrane|focal adhesion|cell junction assembly|negative regulation of apoptotic process|cell-cell junction organization|metal ion binding|cell-cell adhesion|negative regulation of neural precursor cell proliferation|negative regulation of hepatocyte proliferation|positive regulation of integrin-mediated signaling pathway LIMS3 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0414959 0 GeneID:96626,Genbank:NM_033514.4,HGNC:HGNC:30047 LIM zinc finger domain containing 3 GO:0046872 metal ion binding LIMS4 7.95822506048468 6.7071121482403 9.20933797272905 1.37307052114005 0.457405724455352 0.698870584207512 1 0.0641144 0.0821619 0.0606871 0.0452399 GeneID:100288695,Genbank:XM_017003105.2,HGNC:HGNC:39941 LIM zinc finger domain containing 4 GO:0046872 metal ion binding LIN28B 1.02523254288787 1.56626675524197 0.484198330533773 0.309141676482158 -1.69365993276169 0.789571303159055 1 0.0152333 0.00735969 0 0.00684889 GeneID:389421,Genbank:XM_006715477.2,HGNC:HGNC:32207,MIM:611044 lin-28 homolog B LIN37 200.556186701728 178.680905613133 222.431467790322 1.2448530357906 0.315975431408905 0.17603438163768 1 4.52011 5.59922 6.26028 6.68987 GeneID:55957,Genbank:NM_019104.2,HGNC:HGNC:33234 lin-37 DREAM MuvB core complex component GO:0005654,GO:0007049,GO:0017053,GO:0051726 nucleoplasm|cell cycle|transcriptional repressor complex|regulation of cell cycle hsa04218 Cellular senescence LIN52 371.652835687894 394.874761112065 348.430910263724 0.882383339169251 -0.180522544126722 0.343348038322908 1 1.66317 1.67367 1.40481 1.50276 GeneID:91750,Genbank:XM_011537320.3,HGNC:HGNC:19856 lin-52 DREAM MuvB core complex component GO:0005654,GO:0006351,GO:0007049,GO:0051726,GO:0070176 nucleoplasm|transcription, DNA-templated|cell cycle|regulation of cell cycle|DRM complex hsa04218 Cellular senescence LIN54 305.139438773037 310.266930363675 300.0119471824 0.966947869148497 -0.0484899827946204 0.822855111728971 1 1.97056 1.96803 2.12063 1.64405 GeneID:132660,Genbank:NM_001115007.2,HGNC:HGNC:25397,MIM:613367 lin-54 DREAM MuvB core complex component GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0007049,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|metal ion binding hsa04218 Cellular senescence LIN7A 32.7110090585849 28.1065577000935 37.3154604170762 1.32764249593439 0.408866713869461 0.428222001947435 1 0.144895 0.182475 0.234265 0.205482 GeneID:8825,Genbank:NM_001324423.1,HGNC:HGNC:17787,MIM:603380 lin-7 homolog A, crumbs cell polarity complex component GO:0005622,GO:0005911,GO:0005923,GO:0006887,GO:0007269,GO:0014069,GO:0015031,GO:0016020,GO:0016323,GO:0030165,GO:0043005,GO:0045199,GO:0045202,GO:0045211,GO:0048489,GO:0048839,GO:0070062,GO:0097016,GO:0097025,GO:0098793,GO:1903361 intracellular|cell-cell junction|bicellular tight junction|exocytosis|neurotransmitter secretion|postsynaptic density|protein transport|membrane|basolateral plasma membrane|PDZ domain binding|neuron projection|maintenance of epithelial cell apical/basal polarity|synapse|postsynaptic membrane|synaptic vesicle transport|inner ear development|extracellular exosome|L27 domain binding|MPP7-DLG1-LIN7 complex|presynapse|protein localization to basolateral plasma membrane LIN7B 71.4844563005453 76.5745832183327 66.3943293827579 0.867054400981218 -0.205805580605607 0.56690909661696 1 2.09041 1.96034 1.92572 1.93356 GeneID:64130,Genbank:XM_017027131.2,HGNC:HGNC:17788,MIM:612331 lin-7 homolog B, crumbs cell polarity complex component GO:0005886,GO:0005911,GO:0005923,GO:0006887,GO:0007269,GO:0014069,GO:0015031,GO:0016323,GO:0019904,GO:0030165,GO:0043005,GO:0045199,GO:0045202,GO:0045211,GO:0097016,GO:0097025,GO:0098793,GO:1903361 plasma membrane|cell-cell junction|bicellular tight junction|exocytosis|neurotransmitter secretion|postsynaptic density|protein transport|basolateral plasma membrane|protein domain specific binding|PDZ domain binding|neuron projection|maintenance of epithelial cell apical/basal polarity|synapse|postsynaptic membrane|L27 domain binding|MPP7-DLG1-LIN7 complex|presynapse|protein localization to basolateral plasma membrane LIN7C 351.829438199904 393.461364835131 310.197511564677 0.788381120201363 -0.343034867108201 0.223283362314865 1 4.45814 3.7963 3.91193 2.8569 GeneID:55327,Genbank:NM_018362.3,HGNC:HGNC:17789,MIM:612332 lin-7 homolog C, crumbs cell polarity complex component GO:0002011,GO:0005737,GO:0005886,GO:0005911,GO:0005923,GO:0006887,GO:0007269,GO:0008092,GO:0014069,GO:0015031,GO:0016323,GO:0019904,GO:0030165,GO:0043005,GO:0045199,GO:0045202,GO:0045211,GO:0070062,GO:0097016,GO:0097025,GO:0098793,GO:1903361 morphogenesis of an epithelial sheet|cytoplasm|plasma membrane|cell-cell junction|bicellular tight junction|exocytosis|neurotransmitter secretion|cytoskeletal protein binding|postsynaptic density|protein transport|basolateral plasma membrane|protein domain specific binding|PDZ domain binding|neuron projection|maintenance of epithelial cell apical/basal polarity|synapse|postsynaptic membrane|extracellular exosome|L27 domain binding|MPP7-DLG1-LIN7 complex|presynapse|protein localization to basolateral plasma membrane LIN9 199.877119008988 228.657362956821 171.096875061155 0.748267507543432 -0.418373965399738 0.0660145374221291 0.906765721571887 1.29244 1.22797 1.19126 0.801763 GeneID:286826,Genbank:NM_001270410.1,HGNC:HGNC:30830,MIM:609375 lin-9 DREAM MuvB core complex component GO:0005654,GO:0006351,GO:0007049,GO:0017053,GO:0051726,GO:0071897 nucleoplasm|transcription, DNA-templated|cell cycle|transcriptional repressor complex|regulation of cell cycle|DNA biosynthetic process hsa04218 Cellular senescence LINC00452 0.996651292201907 0.538097676642304 1.45520490776151 2.70435084730694 1.43528233092293 0.835161298535314 1 0.015078 0 0 0 GeneID:643365,Genbank:XM_024449396.1,HGNC:HGNC:42800 long intergenic non-protein coding RNA 452 LINC00694 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0108915 0 GeneID:102724231,Genbank:XM_024453307.1,HGNC:HGNC:44570 long intergenic non-protein coding RNA 694 LINC02210-CRHR1 83.7324741855019 87.9903042874068 79.4746440835969 0.90322047101923 -0.146849910477908 0.651594806028777 1 0.923255 0.80787 0.622479 0.740022 GeneID:104909134,Genbank:NM_001256299.2,HGNC:HGNC:51483 LINC02210-CRHR1 readthrough GO:0005768,GO:0007166,GO:0007189,GO:0015056,GO:0016021,GO:0031226,GO:0051458,GO:0071376,GO:2000852 endosome|cell surface receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|corticotrophin-releasing factor receptor activity|integral component of membrane|intrinsic component of plasma membrane|corticotropin secretion|cellular response to corticotropin-releasing hormone stimulus|regulation of corticosterone secretion LINGO1 2.70146001428559 2.00831188251439 3.39460814605679 1.69027937125322 0.757261716455199 0.793393832799777 1 0.010096 0.0260415 0.0558902 0.00872853 GeneID:84894,Genbank:NM_001301186.1,HGNC:HGNC:21205,MIM:609791 leucine rich repeat and Ig domain containing 1 GO:0005154,GO:0005578,GO:0005615,GO:0005886,GO:0007165,GO:0007409,GO:0016021,GO:0050771 epidermal growth factor receptor binding|proteinaceous extracellular matrix|extracellular space|plasma membrane|signal transduction|axonogenesis|integral component of membrane|negative regulation of axonogenesis LINGO2 217.533837575475 200.492970326935 234.574704824016 1.16998967316163 0.226495796010176 0.302652943879892 1 0.283902 0.27799 0.373617 0.310649 GeneID:158038,Genbank:XM_017014303.2,HGNC:HGNC:21207,MIM:609793 leucine rich repeat and Ig domain containing 2 GO:0005578,GO:0005615,GO:0016021,GO:0051965 proteinaceous extracellular matrix|extracellular space|integral component of membrane|positive regulation of synapse assembly LINS1 118.953203497769 132.739672343835 105.166734651702 0.792278094368725 -0.335921181065214 0.225837991274831 1 0.651876 0.711629 0.60298 0.526014 GeneID:55180,Genbank:XM_024449979.1,HGNC:HGNC:30922,MIM:610350 lines homolog 1 GO:0050890 cognition LIPA 4113.14665228254 3921.68883980937 4304.60446475571 1.09764049127492 0.13440560772762 0.31178184038638 1 55.7532 55.3711 65.5286 58.2443 GeneID:3988,Genbank:NM_001288979.1,HGNC:HGNC:6617,MIM:613497 lipase A, lysosomal acid type GO:0000902,GO:0001650,GO:0001816,GO:0004771,GO:0005764,GO:0006954,GO:0008283,GO:0016042,GO:0016298,GO:0030324,GO:0034383,GO:0043202,GO:0043231,GO:0048771,GO:0048873,GO:0070062 cell morphogenesis|fibrillar center|cytokine production|sterol esterase activity|lysosome|inflammatory response|cell proliferation|lipid catabolic process|lipase activity|lung development|low-density lipoprotein particle clearance|lysosomal lumen|intracellular membrane-bounded organelle|tissue remodeling|homeostasis of number of cells within a tissue|extracellular exosome hsa00100,hsa04142,hsa04979 Steroid biosynthesis|Lysosome|Cholesterol metabolism LIPE 245.394954892666 253.795083280702 236.994826504631 0.93380385246672 -0.0988085543655522 0.626480902689075 1 1.28378 1.59415 1.55519 1.23585 GeneID:3991,Genbank:NM_005357.3,HGNC:HGNC:6621,MIM:151750 lipase E, hormone sensitive type hsa04024,hsa04152,hsa04371,hsa04714,hsa04910,hsa04923,hsa04925 cAMP signaling pathway|AMPK signaling pathway|Apelin signaling pathway|Thermogenesis|Insulin signaling pathway|Regulation of lipolysis in adipocytes|Aldosterone synthesis and secretion LIPF 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0250948 0 0 GeneID:8513,Genbank:NM_001198829.1,HGNC:HGNC:6622,MIM:601980 lipase F, gastric type hsa00561,hsa04975 Glycerolipid metabolism|Fat digestion and absorption LIPG 78.329347915126 58.7497163042358 97.9089795260162 1.66654386923324 0.736859294701223 0.0249756843475619 0.631315976879816 0.429096 0.37536 0.843851 0.609672 GeneID:9388,Genbank:XM_005258390.1,HGNC:HGNC:6623,MIM:603684 lipase G, endothelial type GO:0004465,GO:0004620,GO:0005576,GO:0005615,GO:0005769,GO:0005794,GO:0006629,GO:0007584,GO:0008201,GO:0008283,GO:0008970,GO:0009395,GO:0009986,GO:0010983,GO:0032376,GO:0034375,GO:0042632,GO:0043691,GO:0050746,GO:0055091 lipoprotein lipase activity|phospholipase activity|extracellular region|extracellular space|early endosome|Golgi apparatus|lipid metabolic process|response to nutrient|heparin binding|cell proliferation|phosphatidylcholine 1-acylhydrolase activity|phospholipid catabolic process|cell surface|positive regulation of high-density lipoprotein particle clearance|positive regulation of cholesterol transport|high-density lipoprotein particle remodeling|cholesterol homeostasis|reverse cholesterol transport|regulation of lipoprotein metabolic process|phospholipid homeostasis hsa00561,hsa04979 Glycerolipid metabolism|Cholesterol metabolism LIPH 200.182145110856 175.970799919706 224.393490302006 1.27517457671611 0.350694771571496 0.124509727709557 1 1.46647 1.46929 2.10129 1.85936 GeneID:200879,Genbank:XM_011512530.3,HGNC:HGNC:18483,MIM:607365 lipase H GO:0004620,GO:0005615,GO:0005886,GO:0006654,GO:0008201,GO:0016042,GO:0052689 phospholipase activity|extracellular space|plasma membrane|phosphatidic acid biosynthetic process|heparin binding|lipid catabolic process|carboxylic ester hydrolase activity LIPJ 10.3564130736109 11.9920363652935 8.72078978192829 0.727215088103586 -0.459545962315732 0.665455835679314 1 0.103072 0.0622133 0.0385202 0.0787716 GeneID:142910,Genbank:XM_017015740.2,HGNC:HGNC:21773,MIM:613921 lipase family member J GO:0016042,GO:0016788 lipid catabolic process|hydrolase activity, acting on ester bonds LIPN 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00543992 0 GeneID:643418,Genbank:XM_011540083.2,HGNC:HGNC:23452,MIM:613924 lipase family member N GO:0004465,GO:0005576,GO:0016042,GO:0070268 lipoprotein lipase activity|extracellular region|lipid catabolic process|cornification LIPT1 17.7520923340841 17.5749268855642 17.9292577826039 1.02016115909596 0.0287970787289307 1 1 0.360655 0.297772 0.237341 0.280624 GeneID:51601,Genbank:NM_145197.2,HGNC:HGNC:29569,MIM:610284 lipoyltransferase 1 GO:0005759,GO:0006464,GO:0006629,GO:0009249,GO:0016746,GO:0016979,GO:0034641 mitochondrial matrix|cellular protein modification process|lipid metabolic process|protein lipoylation|transferase activity, transferring acyl groups|lipoate-protein ligase activity|cellular nitrogen compound metabolic process hsa00785 Lipoic acid metabolism LIPT2 48.4020137962244 49.7941609000564 47.0098666923924 0.944083921541475 -0.0830129855011685 0.866774183562345 1 1.00318 0.967976 1.02283 0.812043 GeneID:387787,Genbank:NM_001329942.1,HGNC:HGNC:37216,MIM:617659 lipoyl(octanoyl) transferase 2 GO:0005739,GO:0005759,GO:0009249,GO:0016874,GO:0033819,GO:0034641,GO:0102555,GO:2000376 mitochondrion|mitochondrial matrix|protein lipoylation|ligase activity|lipoyl(octanoyl) transferase activity|cellular nitrogen compound metabolic process|octanoyl transferase activity (acting on glycine-cleavage complex H protein)|positive regulation of oxygen metabolic process hsa00785 Lipoic acid metabolism LITAF 1827.86222486867 1925.60003908547 1730.12441065187 0.898485861827029 -0.154432292579536 0.270069973503616 1 18.5906 20.1852 17.7522 17.3199 GeneID:9516,Genbank:NM_001136472.1,HGNC:HGNC:16841,MIM:603795 lipopolysaccharide induced TNF factor hsa04142 Lysosome LIX1 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0293841 GeneID:167410,Genbank:NM_153234.4,HGNC:HGNC:18581,MIM:610466 limb and CNS expressed 1 GO:0005737,GO:0097352 cytoplasm|autophagosome maturation LIX1L 1319.11266321831 1336.02386957313 1302.20145686348 0.974684275124173 -0.0369931257459376 0.823243333594452 1 18.3659 16.5349 17.5763 16.686 GeneID:128077,Genbank:XM_017000316.1,HGNC:HGNC:28715 limb and CNS expressed 1 like GO:0005737,GO:0097352 cytoplasm|autophagosome maturation LKAAEAR1 3.2369477747677 3.084507235799 3.38938831373641 1.09884271769537 0.13598490162883 1 1 0.105279 0.251476 0 0.435552 GeneID:198437,Genbank:XM_005260200.3,HGNC:HGNC:33718 LKAAEAR motif containing 1 LLGL1 2020.11236716954 2111.46156194115 1928.76317239792 0.913473021324972 -0.130565974217885 0.410690469452939 1 18.3211 21.6765 18.4459 18.9113 GeneID:3996,Genbank:XM_011523854.2,HGNC:HGNC:6628,MIM:600966 LLGL1, scribble cell polarity complex component GO:0000137,GO:0005096,GO:0005198,GO:0005737,GO:0005856,GO:0005886,GO:0006461,GO:0006887,GO:0006893,GO:0007409,GO:0017137,GO:0017157,GO:0019901,GO:0030424,GO:0030864,GO:0030866,GO:0031901,GO:0032588,GO:0050708 Golgi cis cisterna|GTPase activator activity|structural molecule activity|cytoplasm|cytoskeleton|plasma membrane|protein complex assembly|exocytosis|Golgi to plasma membrane transport|axonogenesis|Rab GTPase binding|regulation of exocytosis|protein kinase binding|axon|cortical actin cytoskeleton|cortical actin cytoskeleton organization|early endosome membrane|trans-Golgi network membrane|regulation of protein secretion hsa04390,hsa04530,hsa05165 Hippo signaling pathway|Tight junction|Human papillomavirus infection LLGL2 178.235480351714 193.151707952682 163.319252750745 0.845549099626676 -0.242039562923638 0.315450173293776 1 1.12683 1.05399 0.980454 0.895687 GeneID:3993,Genbank:XM_011524802.1,HGNC:HGNC:6629 LLGL2, scribble cell polarity complex component GO:0005096,GO:0005737,GO:0005829,GO:0005886,GO:0006887,GO:0007049,GO:0017137,GO:0017157,GO:0030165,GO:0032878,GO:0043231,GO:0050708,GO:0051301 GTPase activator activity|cytoplasm|cytosol|plasma membrane|exocytosis|cell cycle|Rab GTPase binding|regulation of exocytosis|PDZ domain binding|regulation of establishment or maintenance of cell polarity|intracellular membrane-bounded organelle|regulation of protein secretion|cell division hsa04390,hsa04530,hsa05165 Hippo signaling pathway|Tight junction|Human papillomavirus infection LLPH 487.10247026791 504.110623472162 470.094317063657 0.932522139338761 -0.100790117578379 0.57357428516339 1 14.2554 14.8806 14.3855 12.9595 GeneID:84298,Genbank:NM_032338.3,HGNC:HGNC:28229,MIM:616998 LLP homolog, long-term synaptic facilitation GO:0001099,GO:0003723,GO:0005694,GO:0005730,GO:0060999,GO:0097484 basal RNA polymerase II transcription machinery binding|RNA binding|chromosome|nucleolus|positive regulation of dendritic spine development|dendrite extension LMAN1 656.19645376302 695.387272710422 617.005634815618 0.887283473582577 -0.172532997581261 0.512007367650353 1 6.75741 5.7753 6.37419 4.749 GeneID:3998,Genbank:NM_005570.3,HGNC:HGNC:6631,MIM:601567 lectin, mannose binding 1 GO:0000139,GO:0005537,GO:0005789,GO:0005793,GO:0006457,GO:0006888,GO:0007029,GO:0007030,GO:0007596,GO:0010638,GO:0012507,GO:0015031,GO:0016020,GO:0016021,GO:0018279,GO:0030017,GO:0033116,GO:0044220,GO:0046872,GO:0048208,GO:0051082,GO:0070062 Golgi membrane|mannose binding|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|protein folding|ER to Golgi vesicle-mediated transport|endoplasmic reticulum organization|Golgi organization|blood coagulation|positive regulation of organelle organization|ER to Golgi transport vesicle membrane|protein transport|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|sarcomere|endoplasmic reticulum-Golgi intermediate compartment membrane|host cell perinuclear region of cytoplasm|metal ion binding|COPII vesicle coating|unfolded protein binding|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum LMAN2 8212.13657855873 7860.72366214028 8563.54949497718 1.08940981302039 0.123546767638973 0.360871762331729 1 162.406 171.914 182.157 189.757 GeneID:10960,Genbank:NM_006816.2,HGNC:HGNC:16986,MIM:609551 lectin, mannose binding 2 GO:0000139,GO:0005537,GO:0005615,GO:0005789,GO:0005793,GO:0005794,GO:0005887,GO:0006890,GO:0009986,GO:0015031,GO:0030246,GO:0031072,GO:0033116,GO:0046872,GO:0050766,GO:0070062 Golgi membrane|mannose binding|extracellular space|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|integral component of plasma membrane|retrograde vesicle-mediated transport, Golgi to ER|cell surface|protein transport|carbohydrate binding|heat shock protein binding|endoplasmic reticulum-Golgi intermediate compartment membrane|metal ion binding|positive regulation of phagocytosis|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum LMAN2L 958.499879380128 943.908257430033 973.091501330223 1.03091745799496 0.0439288257142769 0.781212280958188 1 12.1106 12.4429 12.4305 13.4802 GeneID:81562,Genbank:NM_001322351.1,HGNC:HGNC:19263,MIM:609552 lectin, mannose binding 2 like GO:0000139,GO:0005537,GO:0005789,GO:0005794,GO:0006457,GO:0006888,GO:0015031,GO:0016021,GO:0030134,GO:0046872 Golgi membrane|mannose binding|endoplasmic reticulum membrane|Golgi apparatus|protein folding|ER to Golgi vesicle-mediated transport|protein transport|integral component of membrane|COPII-coated ER to Golgi transport vesicle|metal ion binding LMBR1 1385.72917950793 1402.76861578785 1368.689743228 0.975705991582437 -0.0354816073308501 0.826127350277349 1 10.9535 10.6582 11.2276 9.42361 GeneID:64327,Genbank:NM_001350954.1,HGNC:HGNC:13243,MIM:605522 limb development membrane protein 1 GO:0016021,GO:0042733 integral component of membrane|embryonic digit morphogenesis LMBR1L 156.749547735056 168.601128580984 144.897966889127 0.859412793429365 -0.218576841303877 0.362941156221817 1 0.843024 0.983661 0.547762 0.757628 GeneID:55716,Genbank:XM_024449053.1,HGNC:HGNC:18268,MIM:610007 limb development membrane protein 1 like GO:0004872,GO:0005886,GO:0005887,GO:0006898 receptor activity|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis LMBRD1 744.037892958124 733.517806514581 754.557979401666 1.02868392927918 0.040799771631271 0.80822779610932 1 11.3122 12.4612 12.9576 12.4812 GeneID:55788,Genbank:NM_018368.3,HGNC:HGNC:23038,MIM:612625 LMBR1 domain containing 1 GO:0005158,GO:0005765,GO:0005886,GO:0009235,GO:0016020,GO:0016021,GO:0016032,GO:0031419,GO:0038016,GO:0045334,GO:0046325,GO:0046627,GO:0051898 insulin receptor binding|lysosomal membrane|plasma membrane|cobalamin metabolic process|membrane|integral component of membrane|viral process|cobalamin binding|insulin receptor internalization|clathrin-coated endocytic vesicle|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|negative regulation of protein kinase B signaling hsa04977 Vitamin digestion and absorption LMBRD2 209.886673740666 221.516997335562 198.256350145769 0.894993849367881 -0.160050327054542 0.739825436651111 1 1.41282 1.00128 1.32887 0.808214 GeneID:92255,Genbank:XM_011514162.2,HGNC:HGNC:25287 LMBR1 domain containing 2 GO:0016020,GO:0016021 membrane|integral component of membrane LMCD1 1413.22895758109 1425.89024957582 1400.56766558637 0.982240860404948 -0.0258512561889466 0.846484009620993 1 12.3033 13.135 12.7646 12.5435 GeneID:29995,Genbank:NM_014583.3,HGNC:HGNC:6633,MIM:604859 LIM and cysteine rich domains 1 GO:0000122,GO:0003714,GO:0005615,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0008270,GO:0010611,GO:0044267,GO:0070886 negative regulation of transcription from RNA polymerase II promoter|transcription corepressor activity|extracellular space|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|zinc ion binding|regulation of cardiac muscle hypertrophy|cellular protein metabolic process|positive regulation of calcineurin-NFAT signaling cascade LMF1 106.452929852209 99.0218151590014 113.884044545417 1.15009045595207 0.201747335275152 0.549893179059021 1 0.136642 0.187346 0.211427 0.188882 GeneID:64788,Genbank:XM_017023580.1,HGNC:HGNC:14154,MIM:611761 lipase maturation factor 1 GO:0005789,GO:0005794,GO:0006641,GO:0006888,GO:0009306,GO:0016021,GO:0033578,GO:0034382,GO:0051004,GO:0051006,GO:0051604,GO:0090181,GO:0090207 endoplasmic reticulum membrane|Golgi apparatus|triglyceride metabolic process|ER to Golgi vesicle-mediated transport|protein secretion|integral component of membrane|protein glycosylation in Golgi|chylomicron remnant clearance|regulation of lipoprotein lipase activity|positive regulation of lipoprotein lipase activity|protein maturation|regulation of cholesterol metabolic process|regulation of triglyceride metabolic process LMF2 459.605333406535 425.883529604326 493.327137208744 1.15836162451992 0.212085713134694 0.237231326257545 1 5.89586 5.72033 6.86087 6.83626 GeneID:91289,Genbank:NM_033200.2,HGNC:HGNC:25096 lipase maturation factor 2 GO:0005789,GO:0016020,GO:0016021,GO:0051604 endoplasmic reticulum membrane|membrane|integral component of membrane|protein maturation LMLN 221.619724208074 227.061670236256 216.177778179893 0.952066361332415 -0.0708659585091028 0.842953256267838 1 1.32506 1.07309 1.36948 0.963052 GeneID:89782,Genbank:NM_001136049.2,HGNC:HGNC:15991,MIM:609380 leishmanolysin like peptidase GO:0004222,GO:0005811,GO:0005829,GO:0005925,GO:0007049,GO:0007155,GO:0016020,GO:0046872,GO:0051301 metalloendopeptidase activity|lipid droplet|cytosol|focal adhesion|cell cycle|cell adhesion|membrane|metal ion binding|cell division LMLN2 1.24625510652408 2.00831188251439 0.484198330533773 0.241097179551395 -2.05231332105607 0.634444149061074 1 0 0 0 0 GeneID:100128908,Genbank:NM_001354640.1,HGNC:HGNC:53647 leishmanolysin like peptidase 2 GO:0004222,GO:0005737,GO:0007049,GO:0007155,GO:0016020,GO:0046872,GO:0051301 metalloendopeptidase activity|cytoplasm|cell cycle|cell adhesion|membrane|metal ion binding|cell division LMNA 12991.5008665307 11858.5176480771 14124.4840849843 1.19108344770855 0.252274492444619 0.0540858158497383 0.849526737634191 95.8712 99.6282 115.466 119.294 GeneID:4000,Genbank:NM_001282625.1,HGNC:HGNC:6636,MIM:150330 lamin A/C hsa04210,hsa05410,hsa05412,hsa05414 Apoptosis|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) LMNB1 4692.65982367179 4847.01056758289 4538.3090797607 0.936310952180132 -0.0949403613739435 0.489173071846495 1 65.831 61.005 64.8956 54.7928 GeneID:4001,Genbank:NM_005573.3,HGNC:HGNC:6637,MIM:150340 lamin B1 GO:0005198,GO:0005634,GO:0005635,GO:0005637,GO:0005638,GO:0005654,GO:0016020,GO:0016363,GO:0031965,GO:0035722,GO:0043274 structural molecule activity|nucleus|nuclear envelope|nuclear inner membrane|lamin filament|nucleoplasm|membrane|nuclear matrix|nuclear membrane|interleukin-12-mediated signaling pathway|phospholipase binding hsa04210 Apoptosis LMNB2 11048.190066604 10615.5934682173 11480.7866649907 1.08150210342585 0.113036471216754 0.395481329115827 1 100.395 102.588 113.98 109.593 GeneID:84823,Genbank:NM_032737.3,HGNC:HGNC:6638,MIM:150341 lamin B2 GO:0005198,GO:0005637,GO:0005638,GO:0031965 structural molecule activity|nuclear inner membrane|lamin filament|nuclear membrane hsa04210 Apoptosis LMNTD2 29.3494178891024 25.2621818377192 33.4366539404856 1.32358535597907 0.404451235012375 0.444877553700303 1 0.386853 0.161488 0.438339 0.369652 GeneID:256329,Genbank:NM_173573.2,HGNC:HGNC:28561 lamin tail domain containing 2 LMO1 15.3652058831195 15.7106938271046 15.0197179391343 0.956018754131773 -0.0648891751881153 1 1 0.166019 0.062982 0.0916176 0.0975531 GeneID:4004,Genbank:NM_001270428.1,HGNC:HGNC:6641,MIM:186921 LIM domain only 1 LMO2 12.4014496686486 12.6840215210985 12.1188778161987 0.955444438188645 -0.0657561160649429 0.974171149686641 1 0.119408 0.168476 0.200117 0.0933131 GeneID:4005,Genbank:NM_005574.3,HGNC:HGNC:6642,MIM:180385 LIM domain only 2 hsa05202 Transcriptional misregulation in cancer LMO3 3.45514216916722 2.54640955915669 4.36387477917774 1.71373641113056 0.777145226370784 0.715363216635647 1 0.0168796 0.0161162 0.0324725 0.0150855 GeneID:55885,Genbank:NM_001001395.2,HGNC:HGNC:6643,MIM:180386 LIM domain only 3 GO:0046872 metal ion binding LMO4 2348.57448969764 2338.84757344338 2358.3014059519 1.00831770002005 0.0119502737866791 0.9435519044457 1 19.368 21.1737 22.149 19.1433 GeneID:8543,Genbank:NM_006769.3,HGNC:HGNC:6644,MIM:603129 LIM domain only 4 GO:0001158,GO:0001843,GO:0003281,GO:0003700,GO:0005667,GO:0006366,GO:0008134,GO:0021514,GO:0021522,GO:0021527,GO:0030334,GO:0031252,GO:0031333,GO:0033674,GO:0042659,GO:0045944,GO:0046872,GO:0048538,GO:0050865 enhancer sequence-specific DNA binding|neural tube closure|ventricular septum development|DNA binding transcription factor activity|transcription factor complex|transcription from RNA polymerase II promoter|transcription factor binding|ventral spinal cord interneuron differentiation|spinal cord motor neuron differentiation|spinal cord association neuron differentiation|regulation of cell migration|cell leading edge|negative regulation of protein complex assembly|positive regulation of kinase activity|regulation of cell fate specification|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|thymus development|regulation of cell activation LMO7 1064.485547658 1056.84214294087 1072.12895237513 1.01446461000478 0.0207185369909192 0.905552428130861 1 2.8933 2.53001 3.29271 2.36426 GeneID:4008,Genbank:NM_005358.5,HGNC:HGNC:6646,MIM:604362 LIM domain 7 GO:0000151,GO:0000209,GO:0004842,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0016567,GO:0023051,GO:0030155,GO:0043687,GO:0046872 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|cytoplasm|cytosol|focal adhesion|protein ubiquitination|regulation of signaling|regulation of cell adhesion|post-translational protein modification|metal ion binding hsa04520 Adherens junction LMOD1 1.0012194055454 1.51824048055703 0.484198330533773 0.31892070902768 -1.64873031325362 0.791516662337547 1 0.00729634 0.0132958 0 0.00642246 GeneID:25802,Genbank:NM_012134.2,HGNC:HGNC:6647,MIM:602715 leiomodin 1 GO:0003779,GO:0005523,GO:0005829,GO:0005865,GO:0005884,GO:0006936,GO:0016020,GO:0030016,GO:0030017,GO:0030239,GO:0030838,GO:0045010,GO:0051694 actin binding|tropomyosin binding|cytosol|striated muscle thin filament|actin filament|muscle contraction|membrane|myofibril|sarcomere|myofibril assembly|positive regulation of actin filament polymerization|actin nucleation|pointed-end actin filament capping LMTK2 1348.9635941249 1328.76107643974 1369.16611181006 1.03040805159538 0.0432157718098736 0.775580887851415 1 5.85746 5.99742 6.79478 5.64744 GeneID:22853,Genbank:XM_011515981.3,HGNC:HGNC:17880,MIM:610989 lemur tyrosine kinase 2 LMTK3 46.4982734829155 28.0487227703006 64.9478241955304 2.31553588829721 1.21134611742475 0.00382647752494966 0.238835166549544 0.246523 0.121604 0.513068 0.390172 GeneID:114783,Genbank:XM_011526412.2,HGNC:HGNC:19295 lemur tyrosine kinase 3 GO:0000139,GO:0004674,GO:0005524,GO:0010923,GO:0016021,GO:0030424,GO:0030425,GO:0046872 Golgi membrane|protein serine/threonine kinase activity|ATP binding|negative regulation of phosphatase activity|integral component of membrane|axon|dendrite|metal ion binding LMX1B 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0076189 0 0 0 GeneID:4010,Genbank:NM_001174146.1,HGNC:HGNC:6654,MIM:602575 LIM homeobox transcription factor 1 beta GO:0000977,GO:0000983,GO:0001228,GO:0001764,GO:0002930,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0007613,GO:0007626,GO:0008283,GO:0009953,GO:0010468,GO:0010506,GO:0021587,GO:0021954,GO:0030182,GO:0030199,GO:0030326,GO:0030901,GO:0032386,GO:0035108,GO:0035265,GO:0042048,GO:0043010,GO:0045944,GO:0046872,GO:0050808,GO:0071542 RNA polymerase II regulatory region sequence-specific DNA binding|transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|neuron migration|trabecular meshwork development|DNA binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|memory|locomotory behavior|cell proliferation|dorsal/ventral pattern formation|regulation of gene expression|regulation of autophagy|cerebellum morphogenesis|central nervous system neuron development|neuron differentiation|collagen fibril organization|embryonic limb morphogenesis|midbrain development|regulation of intracellular transport|limb morphogenesis|organ growth|olfactory behavior|camera-type eye development|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|synapse organization|dopaminergic neuron differentiation LNP1 116.554847690139 114.376707753096 118.732987627182 1.03808712420269 0.0539275307674915 0.862825759604401 1 2.08133 2.20514 2.16141 2.28283 GeneID:348801,Genbank:NM_001085451.1,HGNC:HGNC:28014 leukemia NUP98 fusion partner 1 LNPEP 635.155370069535 643.036893596101 627.273846542968 0.975486558842713 -0.0358061007045814 0.956681787333369 1 2.55629 1.97841 2.92191 1.54472 GeneID:4012,Genbank:XM_024446045.1,HGNC:HGNC:6656,MIM:151300 leucyl and cystinyl aminopeptidase GO:0000209,GO:0002480,GO:0004177,GO:0005576,GO:0005622,GO:0005765,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0007165,GO:0007267,GO:0007565,GO:0008217,GO:0008237,GO:0008270,GO:0016020,GO:0030163,GO:0030659,GO:0031905,GO:0042277,GO:0043171,GO:0048471,GO:0060395,GO:0061024,GO:0070006 protein polyubiquitination|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent|aminopeptidase activity|extracellular region|intracellular|lysosomal membrane|cytosol|plasma membrane|integral component of plasma membrane|proteolysis|signal transduction|cell-cell signaling|female pregnancy|regulation of blood pressure|metallopeptidase activity|zinc ion binding|membrane|protein catabolic process|cytoplasmic vesicle membrane|early endosome lumen|peptide binding|peptide catabolic process|perinuclear region of cytoplasm|SMAD protein signal transduction|membrane organization|metalloaminopeptidase activity hsa04614 Renin-angiotensin system LNPK 454.754031639714 453.921426718663 455.586636560765 1.00366849799125 0.00528283972982554 0.954218617359215 1 2.11621 1.67389 2.22609 1.67339 GeneID:80856,Genbank:XM_011511945.2,HGNC:HGNC:21610,MIM:610236 lunapark, ER junction formation factor GO:0005654,GO:0005783,GO:0005789,GO:0007596,GO:0016021,GO:0030176,GO:0032330,GO:0035115,GO:0042733,GO:0042802,GO:0046872,GO:0060173,GO:0071788,GO:0098826,GO:1903373 nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|blood coagulation|integral component of membrane|integral component of endoplasmic reticulum membrane|regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|embryonic digit morphogenesis|identical protein binding|metal ion binding|limb development|endoplasmic reticulum tubular network maintenance|endoplasmic reticulum tubular network membrane|positive regulation of endoplasmic reticulum tubular network organization LNX1 446.480678833876 399.563752722683 493.39760494507 1.23484075215279 0.304325000600974 0.0861447753414377 0.964561165794104 1.96606 1.90816 3.03767 2.29748 GeneID:84708,Genbank:XM_017008776.1,HGNC:HGNC:6657,MIM:609732 ligand of numb-protein X 1 GO:0004842,GO:0005737,GO:0030165,GO:0042787,GO:0046872,GO:0051260 ubiquitin-protein transferase activity|cytoplasm|PDZ domain binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|metal ion binding|protein homooligomerization LNX2 245.43928875421 236.430861803238 254.447715705182 1.07620347768701 0.105950873895379 0.61586633851012 1 2.02718 1.88116 2.32461 1.89224 GeneID:222484,Genbank:XM_017020434.1,HGNC:HGNC:20421,MIM:609733 ligand of numb-protein X 2 GO:0030165,GO:0046872,GO:0051260 PDZ domain binding|metal ion binding|protein homooligomerization LOC100129083 4.26141871207728 4.16070258908361 4.36213483507094 1.04841303642222 0.0682071979861005 1 1 0.0991865 0.0568248 0.12152 0.0285266 GeneID:100129083,Genbank:NM_001256795.2 uncharacterized LOC100129083 LOC100129484 2.21302018995993 1.51824048055703 2.90779989936283 1.91524329419539 0.937527669974993 0.766544435698746 1 0.0218116 0.0367895 0.0600311 0.0560741 GeneID:100129484,Genbank:NM_001354886.1 uncharacterized LOC100129484 LOC100129940 0.729234031512454 0.490071401957362 0.968396661067546 1.97603177251261 0.982606144127986 1 1 0 0 0 0.00673516 GeneID:100129940,Genbank:NM_001292024.1 uncharacterized LOC100129940 GO:0016021 integral component of membrane LOC100130357 4.56285530884958 6.21704074628294 2.90866987141623 0.467854400528944 -1.09586847173857 0.48587172079439 1 0.0431081 0.0999952 0.0408671 0.03812 GeneID:100130357,Genbank:NM_001242698.1 uncharacterized LOC100130357 GO:0003677,GO:0005730,GO:0005769,GO:0005829,GO:0006612,GO:0006897,GO:0008270,GO:0017112,GO:0017137,GO:0031901,GO:0055037 DNA binding|nucleolus|early endosome|cytosol|protein targeting to membrane|endocytosis|zinc ion binding|Rab guanyl-nucleotide exchange factor activity|Rab GTPase binding|early endosome membrane|recycling endosome LOC100130370 25.1728954578833 27.5684600234512 22.7773308923155 0.826209765541486 -0.275419982387579 0.640117195036158 1 0.150944 0.132485 0.127614 0.137659 GeneID:100130370,Genbank:XM_024450515.1 uncharacterized LOC100130370 GO:0005654 nucleoplasm LOC100130451 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.0356551 0.0171964 0 0 GeneID:100130451,Genbank:NM_001242575.2 uncharacterized LOC100130451 GO:0003964,GO:0006310,GO:0009036,GO:0032197,GO:0032199,GO:0046872,GO:0090305 RNA-directed DNA polymerase activity|DNA recombination|Type II site-specific deoxyribonuclease activity|transposition, RNA-mediated|reverse transcription involved in RNA-mediated transposition|metal ion binding|nucleic acid phosphodiester bond hydrolysis LOC100130705 50.1130077829622 45.9314246141904 54.294590951734 1.18207940223478 0.24132694698998 0.678870890505424 1 0.464952 0.55261 0.901521 0.442779 GeneID:100130705,Genbank:NM_001195150.2 uncharacterized LOC100130705 LOC100287036 15.7340150067595 15.9606338556373 15.5073961578817 0.971602775813598 -0.041561483210423 1 1 0.245135 0.122588 0.204452 0.309949 GeneID:100287036,Genbank:NM_001242885.2 uncharacterized LOC100287036 LOC100287896 31.3354565783812 29.2307793280631 33.4401338286992 1.1440041831726 0.194092327493336 0.727654987447317 1 0.38563 0.482446 0.573172 0.514495 GeneID:100287896,Genbank:NM_001319240.1 uncharacterized LOC100287896 GO:0005739,GO:0005759,GO:0009249,GO:0016874,GO:0033819,GO:0034641,GO:0102555,GO:2000376 mitochondrion|mitochondrial matrix|protein lipoylation|ligase activity|lipoyl(octanoyl) transferase activity|cellular nitrogen compound metabolic process|octanoyl transferase activity (acting on glycine-cleavage complex H protein)|positive regulation of oxygen metabolic process LOC100289279 11.3125058130083 3.71865746181119 18.9063541642055 5.08418814003833 2.34601741816312 0.0192604905489901 0.567967248609484 0.0307898 0.00743294 0.185892 0.0828866 GeneID:100289279,Genbank:XM_011545672.3 contactin associated protein-like 3-like GO:0005576,GO:0005886,GO:0007155,GO:0008037,GO:0016021 extracellular region|plasma membrane|cell adhesion|cell recognition|integral component of membrane LOC100289561 155.113310548058 143.031171784939 167.195449311176 1.16894413451754 0.225205983094216 0.385438132572028 1 3.17371 4.49655 5.12166 4.52994 GeneID:100289561,Genbank:NM_001347879.1 uncharacterized LOC100289561 GO:0003697,GO:0006298,GO:0006355,GO:0016446,GO:0016887,GO:0032389 single-stranded DNA binding|mismatch repair|regulation of transcription, DNA-templated|somatic hypermutation of immunoglobulin genes|ATPase activity|MutLalpha complex LOC100505549 13.981288376466 13.904295698438 14.058281054494 1.01107466062257 0.0158895338709254 1 1 0.252044 0.216564 0.436467 0.225087 GeneID:100505549,Genbank:NM_001242804.1 uncharacterized LOC100505549 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding LOC100505841 1.0012194055454 1.51824048055703 0.484198330533773 0.31892070902768 -1.64873031325362 0.791516662337547 1 0 0 0.0207946 0.0387225 GeneID:100505841,Genbank:XM_017008912.2 zinc finger protein 474-like GO:0046872 metal ion binding LOC100506248 6.47987698743409 6.65908587355536 6.30066810131283 0.946176130020205 -0.0798193296580105 1 1 0.19836 0.252204 0.184461 0.171442 GeneID:100506248,Genbank:XM_011520895.3 prothymosin alpha GO:0005634 nucleus LOC100506388 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0364161 0 0 GeneID:100506388,Genbank:NM_001242780.1 uncharacterized LOC100506388 LOC100506514 0.972638154859436 0.490071401957362 1.45520490776151 2.96937324224464 1.5701584476161 0.837389832160054 1 0 0 0.00811367 0 GeneID:100506514,Genbank:XM_017008899.1 uncharacterized LOC100506514 GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding LOC100506571 1.47997965068228 0.538097676642304 2.42186162472226 4.50078439259304 2.1701764549285 0.55105548931329 1 0.00674913 0 0.00633996 0.011856 GeneID:100506571,Genbank:XM_003119160.4 uncharacterized LOC100506571 GO:0005829,GO:0016020,GO:0042803,GO:0070062 cytosol|membrane|protein homodimerization activity|extracellular exosome LOC100507507 204.859930348309 174.212428065724 235.507432630894 1.3518405962521 0.434925044700937 0.0555180929472603 0.855410907895938 3.97432 3.80514 5.03632 5.95685 GeneID:100507507,Genbank:NM_001322263.2 uncharacterized LOC100507507 LOC100652901 1.02566752891457 1.56626675524197 0.48506830258717 0.309697119576692 -1.69107012999473 0.789536483244536 1 0.0463163 0 0 0 GeneID:100652901,Genbank:XM_003403493.3 uncharacterized LOC100652901 GO:0000166,GO:0003697,GO:0003727,GO:0005730,GO:0005737,GO:0010494,GO:0030529,GO:0032197,GO:0042802 nucleotide binding|single-stranded DNA binding|single-stranded RNA binding|nucleolus|cytoplasm|cytoplasmic stress granule|intracellular ribonucleoprotein complex|transposition, RNA-mediated|identical protein binding LOC100653133 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0153386 0 0 0 GeneID:100653133,Genbank:XM_024450124.1 golgin subfamily A member 6-like protein 1 GO:0005794 Golgi apparatus LOC100996318 1.95234597274746 2.45035700978681 1.45433493570811 0.593519609550547 -0.752632398408605 0.826314417389259 1 0 0.0302638 0.0202318 0.00943081 GeneID:100996318,Genbank:XM_003846491.4 uncharacterized LOC100996318 LOC100996517 3.20923649613514 2.05633815719933 4.36213483507094 2.12131201271489 1.08495683496113 0.594517883625598 1 0.0135464 0.00663923 0 0.0183896 GeneID:100996517,Genbank:XM_024452077.1 vesicle-trafficking protein SEC22b GO:0000139,GO:0000149,GO:0002479,GO:0005484,GO:0005789,GO:0005793,GO:0006888,GO:0006890,GO:0012507,GO:0015031,GO:0016021,GO:0019905,GO:0030133,GO:0030670,GO:0031201,GO:0033116,GO:0042470,GO:0045732,GO:0048208,GO:0048280,GO:1902902,GO:1990668 Golgi membrane|SNARE binding|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|SNAP receptor activity|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi transport vesicle membrane|protein transport|integral component of membrane|syntaxin binding|transport vesicle|phagocytic vesicle membrane|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|melanosome|positive regulation of protein catabolic process|COPII vesicle coating|vesicle fusion with Golgi apparatus|negative regulation of autophagosome assembly|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane LOC100996643 2.58649619875965 3.71865746181119 1.45433493570811 0.391091395387564 -1.35442229997798 0.583334701794665 1 0.0109362 0.00501546 0.00515803 0.00482502 GeneID:100996643,Genbank:XM_006716911.4 monofunctional C1-tetrahydrofolate synthase, mitochondrial-like GO:0001843,GO:0004329,GO:0004477,GO:0004488,GO:0005524,GO:0005739,GO:0005759,GO:0006760,GO:0009113,GO:0009257,GO:0015942,GO:0016020,GO:0035999,GO:0042803,GO:0046653,GO:0046655,GO:0048702,GO:0048703 neural tube closure|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|ATP binding|mitochondrion|mitochondrial matrix|folic acid-containing compound metabolic process|purine nucleobase biosynthetic process|10-formyltetrahydrofolate biosynthetic process|formate metabolic process|membrane|tetrahydrofolate interconversion|protein homodimerization activity|tetrahydrofolate metabolic process|folic acid metabolic process|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis LOC100996693 1.51323738118684 2.05633815719933 0.97013660517434 0.471778730447542 -1.08381771694066 0.811628731439594 1 0.127047 0 0.117664 0 GeneID:100996693,Genbank:NM_001286811.1 CAVP-target protein-like LOC100996716 72.9475783425351 74.6623238851882 71.232832799882 0.954066644234382 -0.067838048836566 0.875686568576514 1 0.0859629 0.202754 0.178341 0.210309 GeneID:100996716,Genbank:XM_017003059.1 vesicle-trafficking protein SEC22b GO:0000139,GO:0000149,GO:0002479,GO:0005484,GO:0005789,GO:0005793,GO:0006888,GO:0006890,GO:0012507,GO:0015031,GO:0016021,GO:0019905,GO:0030133,GO:0030670,GO:0031201,GO:0033116,GO:0042470,GO:0045732,GO:0048208,GO:0048280,GO:1902902,GO:1990668 Golgi membrane|SNARE binding|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|SNAP receptor activity|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi transport vesicle membrane|protein transport|integral component of membrane|syntaxin binding|transport vesicle|phagocytic vesicle membrane|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|melanosome|positive regulation of protein catabolic process|COPII vesicle coating|vesicle fusion with Golgi apparatus|negative regulation of autophagosome assembly|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane LOC100996717 25.7314164970531 27.2224674455487 24.2403655485575 0.890454386511581 -0.167386383660384 0.801984754711113 1 0.0595303 0.0523662 0.0769282 0.0256037 GeneID:100996717,Genbank:XM_017003047.2 notch homolog 2 N-terminal-like protein GO:0005509,GO:0005576,GO:0005737,GO:0007219,GO:0007275,GO:0030154 calcium ion binding|extracellular region|cytoplasm|Notch signaling pathway|multicellular organism development|cell differentiation LOC100996720 11.5897254456828 11.549991238021 11.6294596533445 1.00688038749864 0.00989230835756791 1 1 0.0715532 0.119038 0.129699 0 GeneID:100996720,Genbank:XM_017003015.1 uncharacterized LOC100996720 GO:0003950,GO:0005622 NAD+ ADP-ribosyltransferase activity|intracellular LOC100996721 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0147457 0 GeneID:100996721,Genbank:XM_005277507.4 protein FAM231D LOC100996741 1.04968066625704 1.61429302992691 0.48506830258717 0.300483427478549 -1.73464267051938 0.787636841365487 1 0.0323482 0 0.0102319 0 GeneID:100996741,Genbank:NM_001348152.1 uncharacterized LOC100996741 LOC100996763 45.6310288257913 52.9747206852253 38.2873369663573 0.72274731175762 -0.468436757246834 0.276641537703524 1 0.209715 0.19372 0.147705 0.137737 GeneID:100996763,Genbank:XM_024452035.1 notch homolog 2 N-terminal-like protein GO:0005509,GO:0005576,GO:0005737,GO:0007219,GO:0007275,GO:0030154 calcium ion binding|extracellular region|cytoplasm|Notch signaling pathway|multicellular organism development|cell differentiation LOC100996792 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0689468 GeneID:100996792,Genbank:XM_011524134.3 dual specificity mitogen-activated protein kinase kinase 3 GO:0000187,GO:0004674,GO:0004708,GO:0004713,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006954,GO:0007165,GO:0007346,GO:0016020,GO:0019901,GO:0023014,GO:0031098,GO:0032147,GO:0035897,GO:0042035,GO:0042981,GO:0045860,GO:0045893,GO:0060048 activation of MAPK activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|ATP binding|nucleoplasm|cytoplasm|cytosol|inflammatory response|signal transduction|regulation of mitotic cell cycle|membrane|protein kinase binding|signal transduction by protein phosphorylation|stress-activated protein kinase signaling cascade|activation of protein kinase activity|proteolysis in other organism|regulation of cytokine biosynthetic process|regulation of apoptotic process|positive regulation of protein kinase activity|positive regulation of transcription, DNA-templated|cardiac muscle contraction LOC100996842 111.505233967965 123.18818433322 99.8222836027095 0.810323523664359 -0.30343007232339 0.291437466929059 1 2.49893 2.89059 2.04471 2.15426 GeneID:100996842,Genbank:NM_001322800.1 uncharacterized LOC100996842 LOC100996911 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.024197 0 0 0 GeneID:100996911,Genbank:XM_017030092.2 putative ubiquitin-conjugating enzyme E2Q2-like protein GO:0000187,GO:0001525,GO:0004871,GO:0005576,GO:0005796,GO:0005887,GO:0005925,GO:0007169,GO:0008283,GO:0008347,GO:0009986,GO:0016324,GO:0019901,GO:0030203,GO:0030206,GO:0030207,GO:0030208,GO:0031012,GO:0031258,GO:0035556,GO:0043202,GO:0048771,GO:0050731,GO:0070062 activation of MAPK activity|angiogenesis|signal transducer activity|extracellular region|Golgi lumen|integral component of plasma membrane|focal adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|cell proliferation|glial cell migration|cell surface|apical plasma membrane|protein kinase binding|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|chondroitin sulfate catabolic process|dermatan sulfate biosynthetic process|extracellular matrix|lamellipodium membrane|intracellular signal transduction|lysosomal lumen|tissue remodeling|positive regulation of peptidyl-tyrosine phosphorylation|extracellular exosome LOC101059906 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0 0 0.016019 0 GeneID:101059906,Genbank:XM_003959933.4 collagen alpha-2(IV) chain-like LOC101059915 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:101059915,Genbank:NM_001323075.1 chromosome X open reading frame 49-like LOC101060022 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0227016 GeneID:101060022,Genbank:XM_011544347.3 nascent polypeptide-associated complex subunit alpha, muscle-specific form-like LOC101060179 157.819157349785 155.225121904081 160.413192795489 1.03342288173312 0.0474307329410474 0.8830300912353 1 2.57998 2.89874 2.92735 2.8074 GeneID:101060179,Genbank:XM_003959932.5 uncharacterized LOC101060179 LOC101060254 4.53460067771522 5.67894306964064 3.39025828578981 0.596987545783646 -0.744227260254216 0.66024865052064 1 0.0397967 0.0280638 0 0.0618606 GeneID:101060254,Genbank:XM_024452074.1 myomegalin-like LOC101927245 10.6415225079977 6.26506702096788 15.0179779950275 2.39709773969943 1.26128873489646 0.205665077741199 1 0.0610038 0 0.272861 0.102522 GeneID:101927245,Genbank:XM_011517419.2 vegetative cell wall protein gp1-like LOC101927262 4.26642181144747 5.14084539299833 3.3919982298966 0.659813312906938 -0.599870207752848 0.750183006166852 1 0.0362109 0.0224135 0.0230096 0.0107559 GeneID:101927262,Genbank:XM_011510431.2 melanoma-associated antigen C1-like GO:0005576,GO:0010976,GO:0030298,GO:0030971,GO:0070374,GO:0070378 extracellular region|positive regulation of neuron projection development|receptor signaling protein tyrosine kinase activator activity|receptor tyrosine kinase binding|positive regulation of ERK1 and ERK2 cascade|positive regulation of ERK5 cascade LOC101927322 29.284651966859 20.765295325841 37.804008607877 1.82053797042956 0.864364830965978 0.109175385969501 1 0.589771 1.0586 1.70771 1.24851 GeneID:101927322,Genbank:NM_001289967.1 uncharacterized LOC101927322 LOC101927401 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0148208 0 GeneID:101927401,Genbank:XM_017003091.1 MAGE-like protein 2 GO:0004674,GO:0005085,GO:0005089,GO:0005516,GO:0005524,GO:0005829,GO:0005886,GO:0007186,GO:0007275,GO:0008307,GO:0016604,GO:0030016,GO:0030018,GO:0030506,GO:0031430,GO:0031432,GO:0035023,GO:0036309,GO:0042383,GO:0043065,GO:0045214,GO:0046872,GO:0051056 protein serine/threonine kinase activity|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|calmodulin binding|ATP binding|cytosol|plasma membrane|G-protein coupled receptor signaling pathway|multicellular organism development|structural constituent of muscle|nuclear body|myofibril|Z disc|ankyrin binding|M band|titin binding|regulation of Rho protein signal transduction|protein localization to M-band|sarcolemma|positive regulation of apoptotic process|sarcomere organization|metal ion binding|regulation of small GTPase mediated signal transduction LOC101927506 3.70518096951609 4.01662376502878 3.3937381740034 0.844923092760488 -0.243108065613907 0.953366981910967 1 0.00804832 0.0461794 0.00771691 0.00718527 GeneID:101927506,Genbank:XM_017014134.2 uncharacterized LOC101927506 GO:0005525,GO:0005737,GO:0005856,GO:0007049,GO:0051301 GTP binding|cytoplasm|cytoskeleton|cell cycle|cell division LOC101927509 40.3990160216593 45.4315445571251 35.3664874861935 0.778456639124918 -0.361311413016127 0.522389684496324 1 0.135264 0.10121 0.0680179 0.120501 GeneID:101927509,Genbank:XM_017005451.1 basic proline-rich protein-like LOC101927572 25.8851860150819 29.4807193565957 22.2896526735681 0.756075603310583 -0.403397591832877 0.468555947267408 1 0.290888 0.634716 0.387873 0.469131 GeneID:101927572,Genbank:NM_001347907.1 uncharacterized LOC101927572 GO:0001934,GO:0005795,GO:0005802,GO:0005886,GO:0008017,GO:0010828,GO:0018230,GO:0031115,GO:0031901,GO:0032588,GO:0035594,GO:0043065,GO:0044091,GO:0045121,GO:0045444,GO:0045807,GO:0055038,GO:0072321,GO:1903078 positive regulation of protein phosphorylation|Golgi stack|trans-Golgi network|plasma membrane|microtubule binding|positive regulation of glucose transport|peptidyl-L-cysteine S-palmitoylation|negative regulation of microtubule polymerization|early endosome membrane|trans-Golgi network membrane|ganglioside binding|positive regulation of apoptotic process|membrane biogenesis|membrane raft|fat cell differentiation|positive regulation of endocytosis|recycling endosome membrane|chaperone-mediated protein transport|positive regulation of protein localization to plasma membrane LOC101927789 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.016711 0 0 GeneID:101927789,Genbank:XM_005274417.4 putative ubiquitin-like protein FUBI-like protein ENSP00000310146 LOC101927824 3.44363678025022 4.94874029425856 1.93853326624189 0.391722569982291 -1.35209584006449 0.508718857437094 1 0 0.105228 0.0185366 0.034732 GeneID:101927824,Genbank:XM_011519781.2 translation initiation factor IF-2-like LOC101927844 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:101927844,Genbank:XM_016999997.1 uncharacterized LOC101927844 GO:0016021 integral component of membrane LOC101928095 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00900388 0 0 0 GeneID:101928095,Genbank:XM_017014146.1 serine/arginine-rich splicing factor RSZ22-like LOC101928120 124.890106438726 122.83238310021 126.947829777242 1.03350457406395 0.0475447738284474 0.894343559060448 1 3.30553 3.46586 2.81672 4.06862 GeneID:101928120,Genbank:NM_001321726.1 uncharacterized LOC101928120 LOC101928208 1.02316597922947 1.07619535328461 0.97013660517434 0.901450282435646 -0.149680169798226 1 1 0.0811672 0 0 0 GeneID:101928208,Genbank:XM_005249924.3 probable C-mannosyltransferase DPY19L2 GO:0000030,GO:0005634,GO:0005637,GO:0007275,GO:0007286,GO:0016021,GO:0018406 mannosyltransferase activity|nucleus|nuclear inner membrane|multicellular organism development|spermatid development|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan LOC101928212 1.48084962273568 0.538097676642304 2.42360156882906 4.50401790238564 2.17121256179462 0.55094696455999 1 0.011688 0 0.0327619 0 GeneID:101928212,Genbank:XM_017028524.1 uncharacterized LOC101928212 LOC101928268 1.75196502471523 1.56626675524197 1.93766329418849 1.23712214902317 0.306987953903475 1 1 0.0717313 0 0.0339684 0.0316622 GeneID:101928268,Genbank:XM_005249925.3 uncharacterized LOC101928268 LOC101928422 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0147897 0 0.0139962 0 GeneID:101928422,Genbank:XM_017012897.1 TRPM8 channel-associated factor 2-like GO:0005886,GO:0010360,GO:0030054,GO:0030335,GO:0044325,GO:0090314 plasma membrane|negative regulation of anion channel activity|cell junction|positive regulation of cell migration|ion channel binding|positive regulation of protein targeting to membrane LOC101928436 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0.029435 0 0.028418 0 GeneID:101928436,Genbank:NM_001286997.2 uncharacterized LOC101928436 LOC101928592 1.02523254288787 1.56626675524197 0.484198330533773 0.309141676482158 -1.69365993276169 0.789571303159055 1 0.0279041 0 0 0.0247799 GeneID:101928592,Genbank:XM_005265640.3 zinc finger protein OZF-like LOC101928635 4.43778652276704 4.99676656894351 3.87880647659057 0.776263294086737 -0.365382024116205 0.85084283563041 1 0.0134312 0.0507318 0.0513106 0 GeneID:101928635,Genbank:XM_024450125.1 uncharacterized LOC101928635 LOC101928764 5.68336588933423 2.64246210852658 8.72426967014188 3.3015685038551 1.72315158057026 0.184261687818935 1 0.039876 0.0122462 0.113231 0.070487 GeneID:101928764,Genbank:XM_017020891.1 coiled-coil domain-containing protein 144B LOC101928841 19.7874622561278 21.6395769252779 17.9353475869777 0.828821545306037 -0.270866588361249 0.708362103765186 1 0.0835759 0.0597268 0.0811665 0.0462669 GeneID:101928841,Genbank:XM_011537461.2 collagen alpha-1(II) chain-like GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding LOC101929322 6.89790897736404 7.49514985341526 6.30066810131283 0.840632705754622 -0.250452507643123 0.856500009623103 1 0.0250008 0.162852 0.142654 0.0438394 GeneID:101929322,Genbank:XM_011516746.2 integrator complex subunit 4-like protein 2 GO:0005634,GO:0005654,GO:0016180,GO:0032039,GO:0042795 nucleus|nucleoplasm|snRNA processing|integrator complex|snRNA transcription from RNA polymerase II promoter LOC101929372 1.76077463185061 3.03648096111406 0.48506830258717 0.159746861185391 -2.64614051048666 0.397050141148617 1 0.0260072 0.0232215 0 0 GeneID:101929372,Genbank:NM_001288707.1 uncharacterized LOC101929372 GO:0005280,GO:0005314,GO:0005743,GO:0006811,GO:0006839,GO:0016021 hydrogen:amino acid symporter activity|high-affinity glutamate transmembrane transporter activity|mitochondrial inner membrane|ion transport|mitochondrial transport|integral component of membrane LOC101929479 17.7722130980399 21.0054266992657 14.5389994968141 0.692154446799329 -0.530834099265644 0.445885931341027 1 0.371643 0.549099 0.275761 0.225901 GeneID:101929479,Genbank:XM_017022812.1 golgin subfamily A member 2 GO:0000137,GO:0000139,GO:0000922,GO:0005794,GO:0005801,GO:0005874,GO:0006486,GO:0006888,GO:0007020,GO:0007098,GO:0008017,GO:0008356,GO:0010507,GO:0019901,GO:0019905,GO:0030134,GO:0032091,GO:0032580,GO:0033116,GO:0045296,GO:0048208,GO:0051225,GO:0051289,GO:0060050,GO:0061676,GO:0072686,GO:0090161,GO:0090166,GO:0090306,GO:0090307,GO:1904668 Golgi cis cisterna|Golgi membrane|spindle pole|Golgi apparatus|cis-Golgi network|microtubule|protein glycosylation|ER to Golgi vesicle-mediated transport|microtubule nucleation|centrosome cycle|microtubule binding|asymmetric cell division|negative regulation of autophagy|protein kinase binding|syntaxin binding|COPII-coated ER to Golgi transport vesicle|negative regulation of protein binding|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|cadherin binding|COPII vesicle coating|spindle assembly|protein homotetramerization|positive regulation of protein glycosylation|importin-alpha family protein binding|mitotic spindle|Golgi ribbon formation|Golgi disassembly|spindle assembly involved in meiosis|mitotic spindle assembly|positive regulation of ubiquitin protein ligase activity LOC101929692 3.01516360555319 2.15239070656922 3.87793650453717 1.80168799869907 0.84934919888641 0.685801509896412 1 0.0687148 0 0.0953903 0.05935 GeneID:101929692,Genbank:XM_024446615.1 uncharacterized LOC101929692 LOC101929796 43.9301950311797 37.9462033588178 49.9141867035417 1.31539343294914 0.395494372803745 0.367081563116109 1 0.428125 0.38968 0.581054 0.627444 GeneID:101929796,Genbank:XM_017003012.1 notch homolog 2 N-terminal-like protein LOC101929895 59.9710943147673 55.482912624805 64.4592760047296 1.1617860879191 0.216344459183307 0.596033221112404 1 0.619202 0.708557 0.782193 0.570847 GeneID:101929895,Genbank:XM_017010126.1 uncharacterized LOC101929895 GO:0001578,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0008017,GO:0015631,GO:0031334,GO:0032273,GO:0043209,GO:0046785,GO:0048471,GO:0097427 microtubule bundle formation|nucleus|cytoplasm|mitochondrion|cytosol|microtubule|microtubule binding|tubulin binding|positive regulation of protein complex assembly|positive regulation of protein polymerization|myelin sheath|microtubule polymerization|perinuclear region of cytoplasm|microtubule bundle LOC101929937 38.5418589093513 35.409602454769 41.6741153639336 1.17691565210783 0.235010928153545 0.65916756510601 1 0 0.0845481 0.119058 0.139861 GeneID:101929937,Genbank:XM_017028182.1 uncharacterized LOC101929937 GO:0005886,GO:0016021,GO:0030133,GO:0043025 plasma membrane|integral component of membrane|transport vesicle|neuronal cell body LOC101929950 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.054322 0 0.052154 0 GeneID:101929950,Genbank:XM_017025500.2 puromycin-sensitive aminopeptidase-like protein GO:0005737,GO:0006508,GO:0008270,GO:0042277,GO:0043171,GO:0070006,GO:0070062 cytoplasm|proteolysis|zinc ion binding|peptide binding|peptide catabolic process|metalloaminopeptidase activity|extracellular exosome LOC101929959 24.9352320185049 23.6959150824773 26.1745489545324 1.10460173677311 0.143526300882991 0.825449484322904 1 0.0964829 0.100125 0.0843797 0.0942085 GeneID:101929959,Genbank:XM_017015377.1 ribosome biogenesis protein BMS1 homolog GO:0000462,GO:0000479,GO:0003723,GO:0003924,GO:0005524,GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0030686,GO:0034511 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|GTPase activity|ATP binding|GTP binding|nucleus|nucleoplasm|nucleolus|rRNA processing|90S preribosome|U3 snoRNA binding LOC101930307 45.5266016553127 51.3124013806134 39.7408019300121 0.774487275215046 -0.368686559080988 0.392638325339826 1 0.908458 0.798951 0.677224 0.728759 GeneID:101930307,Genbank:XM_017015419.1 uncharacterized LOC101930307 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding LOC101930420 1.0016543915721 1.51824048055703 0.48506830258717 0.319493722370782 -1.64614051048666 0.791481013618379 1 0.0274422 0.0261531 0.026354 0 GeneID:101930420,Genbank:XM_017007609.2 DNA primase large subunit-like GO:0000082,GO:0003697,GO:0003887,GO:0003896,GO:0005654,GO:0005658,GO:0006269,GO:0006270,GO:0032201,GO:0046872,GO:0051539 G1/S transition of mitotic cell cycle|single-stranded DNA binding|DNA-directed DNA polymerase activity|DNA primase activity|nucleoplasm|alpha DNA polymerase:primase complex|DNA replication, synthesis of RNA primer|DNA replication initiation|telomere maintenance via semi-conservative replication|metal ion binding|4 iron, 4 sulfur cluster binding LOC101930434 2.55954652570539 3.18055978516888 1.93853326624189 0.609494364885505 -0.71431521249851 0.832891272622292 1 0.100345 0 0.0317097 0.0590049 GeneID:101930434,Genbank:XM_017022809.1 putative golgin subfamily A member 8I GO:0005794 Golgi apparatus LOC102723360 6.59275173844796 1.07619535328461 12.1093081236113 11.2519609814826 3.49210454981586 0.0991391207164106 1 0.0140993 0 0.00679069 0.0126447 GeneID:102723360,Genbank:NM_001322975.1 uncharacterized LOC102723360 GO:0005654 nucleoplasm LOC102723534 0.780196841909191 1.07619535328461 0.484198330533773 0.449916763769675 -1.15226997256519 0.981239839765731 1 0.11947 0 0 0 GeneID:102723534,Genbank:XM_006720794.3 E3 ubiquitin-protein ligase HERC2-like LOC102723722 3.0020266390045 4.06465003971372 1.93940323829528 0.47713904502142 -1.06751834578182 0.612681170571041 1 0 0.04602 0 0 GeneID:102723722,Genbank:XM_017029174.2 uncharacterized LOC102723722 LOC102723728 6.39870134871969 4.55472144167109 8.2426812557683 1.80970040897696 0.855750882801542 0.509820808648306 1 2.78134 2.85277 2.70557 2.55603 GeneID:102723728,Genbank:XM_006720996.3 nodal modulator 3-like GO:0016021,GO:0030246 integral component of membrane|carbohydrate binding LOC102723750 2.04752855006395 2.64246210852658 1.45259499160132 0.549712704267035 -0.863250273377329 0.823939110949976 1 0.0210799 0 0 0.012291 GeneID:102723750,Genbank:XM_017022794.2 uncharacterized LOC102723750 LOC102723996 4.28543184941975 4.20872886376855 4.36213483507094 1.03644947827906 0.0516497940038401 1 1 0.0407649 0.0142037 0.0377921 0.0141519 GeneID:102723996,Genbank:XM_011546078.2 ICOS ligand GO:0002250,GO:0005102,GO:0005886,GO:0006952,GO:0006972,GO:0007165,GO:0016021,GO:0031295,GO:0036464,GO:0042104,GO:0042110,GO:0042113,GO:0070062 adaptive immune response|receptor binding|plasma membrane|defense response|hyperosmotic response|signal transduction|integral component of membrane|T cell costimulation|cytoplasmic ribonucleoprotein granule|positive regulation of activated T cell proliferation|T cell activation|B cell activation|extracellular exosome hsa04514,hsa04672 Cell adhesion molecules (CAMs)|Intestinal immune network for IgA production LOC102724135 11.2094334339795 17.0848554836069 5.33401138435208 0.312206994637451 -1.67942523529184 0.0604398162507587 0.880242025342909 0.0352909 0.0319118 0 0 GeneID:102724135,Genbank:XM_011522304.2 uncharacterized LOC102724135 GO:0005794 Golgi apparatus LOC102724159 344.350579844514 325.766918782678 362.934240906349 1.11409176310031 0.155868066356179 0.588336943819884 1 3.30485 3.71698 3.44961 4.69262 GeneID:102724159,Genbank:XM_006723910.2 periodic tryptophan protein 2 homolog GO:0000028,GO:0000462,GO:0003723,GO:0005654,GO:0006364,GO:0030515,GO:0032040,GO:0034388 ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|rRNA processing|snoRNA binding|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome LOC102724200 11.2810249537854 12.3860552178809 10.1759946896898 0.821568652059567 -0.283546959946215 0.793811053059045 1 0.145291 0.104747 0.107727 0.114689 GeneID:102724200,Genbank:XM_011546082.3 trafficking protein particle complex subunit 10-like GO:0000139,GO:0005829,GO:0006814,GO:0006891,GO:0015081,GO:0016021,GO:0017112,GO:0030008,GO:0034498,GO:0048208,GO:0051259,GO:1990071 Golgi membrane|cytosol|sodium ion transport|intra-Golgi vesicle-mediated transport|sodium ion transmembrane transporter activity|integral component of membrane|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|early endosome to Golgi transport|COPII vesicle coating|protein oligomerization|TRAPPII protein complex LOC102724219 2.51402180070554 3.57457863775636 1.45346496365472 0.40661155088394 -1.29827689552794 0.586956146241499 1 0.020688 0.0199422 0.00664383 0.0123704 GeneID:102724219,Genbank:NM_001322044.1 uncharacterized LOC102724219 GO:0005654 nucleoplasm LOC102724378 6.45673382214502 6.61105959887042 6.30240804541962 0.953312846626956 -0.0689783569209239 1 1 0 0.0871652 0.0923067 0.086454 GeneID:102724378,Genbank:XM_017029173.1 uncharacterized LOC102724378 LOC102724474 9.62001060725361 9.06141660865723 10.17860460585 1.12329065591415 0.167731279109756 0.940239705810225 1 0.141325 0.281663 0.302917 0.285438 GeneID:102724474,Genbank:XM_011537532.3 WAS/WASL-interacting protein family member 2-like LOC102724624 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.144101 0 GeneID:102724624,Genbank:XM_011524126.3 uncharacterized protein ENSP00000382042-like LOC102724642 1.96841947500795 1.02816907859967 2.90866987141623 2.8289801083862 1.50028203264315 0.612213169729345 1 0.0368976 0.0173574 0.0706289 0.0164431 GeneID:102724642,Genbank:XM_024453280.1 anaphase-promoting complex subunit 1-like GO:0005654,GO:0005680,GO:0005829,GO:0031145,GO:0042787,GO:0043161,GO:0051301,GO:0051436,GO:0051437,GO:0051439,GO:0070979 nucleoplasm|anaphase-promoting complex|cytosol|anaphase-promoting complex-dependent catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination LOC102724646 11.0642438839411 12.4340814925659 9.69440627531622 0.77966404523827 -0.35907548972954 0.73166037221022 1 0.15813 0.108665 0.164741 0.0637241 GeneID:102724646,Genbank:XM_024446614.1 translation initiation factor IF-2-like LOC102724720 1.21430233409962 0.490071401957362 1.93853326624189 3.95561393400904 1.98390162663545 0.683537482026705 1 0 0.0120928 0.0249641 0.02336 GeneID:102724720,Genbank:XM_017010129.1 uncharacterized LOC102724720 GO:0016021 integral component of membrane LOC102724843 25.8004968725151 23.4940013286296 28.1069924164005 1.19634761330117 0.258636642981036 0.63396592652607 1 0.0570311 0.0376332 0.0514879 0.0415188 GeneID:102724843,Genbank:XM_017028222.2 uncharacterized LOC102724843 GO:0016021 integral component of membrane LOC102724965 7.5606404540622 9.7916193840393 5.32966152408509 0.544308486170595 -0.877503565969689 0.439951041445889 1 0.20933 0.137584 0.0730688 0.0906232 GeneID:102724965,Genbank:XM_024453278.1 uncharacterized LOC102724965 LOC102725180 21.9641894080552 20.1791713745138 23.7492074415966 1.17691688131415 0.235012434947115 0.759268438101053 1 0.136983 0.102038 0.109969 0.147553 GeneID:102725180,Genbank:XM_017027551.1 collagen alpha-1(VII) chain-like LOC105369155 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.213469 GeneID:105369155,Genbank:XM_011523526.3 uncharacterized LOC105369155 LOC105369199 3.71657799195798 2.10436443188427 5.32879155203169 2.53225699469755 1.34042382900041 0.436591999696228 1 0.00903022 0 0 0.00806712 GeneID:105369199,Genbank:XM_017003016.2 neuroblastoma breakpoint family member 6-like protein LOC105369205 205.794051311301 233.278710982539 178.309391640064 0.764362040964 -0.387671960570913 0.286831883729625 1 1.44591 1.11166 0.813779 1.21207 GeneID:105369205,Genbank:XM_011524128.3 uncharacterized LOC105369205 LOC105369214 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0217389 GeneID:105369214,Genbank:XM_011514190.2 uncharacterized LOC105369214 LOC105369246 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0308072 0 0 GeneID:105369246,Genbank:XM_011523514.3 uncharacterized LOC105369246 LOC105369669 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0.0809857 0 0 0 GeneID:105369669,Genbank:XM_011520896.2 uncharacterized LOC105369669 LOC105369728 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0813927 GeneID:105369728,Genbank:XM_011520905.1 serine/arginine repetitive matrix protein 1 LOC105369869 1.02316597922947 1.07619535328461 0.97013660517434 0.901450282435646 -0.149680169798226 1 1 0.00788041 0 0.00757146 0 GeneID:105369869,Genbank:XM_011539062.3 uncharacterized LOC105369869 LOC105370045 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:105370045,Genbank:XM_011539088.1 refilin-A GO:0005737,GO:0005856,GO:0031005,GO:0061181,GO:0061572 cytoplasm|cytoskeleton|filamin binding|regulation of chondrocyte development|actin filament bundle organization LOC105370092 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00915382 0 GeneID:105370092,Genbank:XM_017020297.1 uncharacterized LOC105370092 GO:0003677,GO:0005634 DNA binding|nucleus LOC105370362 2.53009530296602 2.15239070656922 2.90779989936283 1.35096285748125 0.43398801066343 0.906986334118966 1 0.0834053 0 0.0582523 0.0547819 GeneID:105370362,Genbank:XM_011521139.2 uncharacterized LOC105370362 LOC105370579 7.4748967020043 6.7071121482403 8.2426812557683 1.22894638908504 0.297421981708832 0.83453121776078 1 0.0750863 0.0688251 0.106934 0.0442898 GeneID:105370579,Genbank:XM_017021843.2 uncharacterized LOC105370579 GO:0016021 integral component of membrane LOC105370641 1.99700072569391 2.05633815719933 1.93766329418849 0.942288255170796 -0.0857596330424504 1 1 0.0360435 0.0328458 0.0169326 0.0477974 GeneID:105370641,Genbank:XM_011537447.1 uncharacterized LOC105370641 LOC105370687 42.1584712691087 41.664860820629 42.6520817175885 1.02369432844645 0.0337849959364866 0.96162064382395 1 0.519634 0.487777 0.763165 0.529145 GeneID:105370687,Genbank:XM_017021845.1 uncharacterized LOC105370687 LOC105370705 6.32665234203341 5.87104816838041 6.78225651568641 1.15520369126138 0.208147257237288 0.912040592325148 1 0.449289 0.0917802 0.099475 0.370713 GeneID:105370705,Genbank:XM_011537450.1 collagen alpha-2(I) chain-like LOC105371371 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:105371371,Genbank:XM_011523509.2 uncharacterized LOC105371371 GO:0007275,GO:0008083,GO:0030154,GO:0030308,GO:0043065 multicellular organism development|growth factor activity|cell differentiation|negative regulation of cell growth|positive regulation of apoptotic process LOC105371419 1.48585272210587 1.51824048055703 1.45346496365472 0.957335140426142 -0.0629040282857778 1 1 0.00972874 0.0169571 0.0090235 0.0169525 GeneID:105371419,Genbank:XM_011523522.2 uncharacterized LOC105371419 GO:0005576 extracellular region LOC105371448 26.664720023229 31.0371774567298 22.2922625897283 0.718243874489131 -0.477454311037448 0.409018504556506 1 0.141573 0.0952989 0.0864632 0.0734741 GeneID:105371448,Genbank:XM_017003085.2 uncharacterized LOC105371448 GO:0005887,GO:0050885 integral component of plasma membrane|neuromuscular process controlling balance LOC105371566 8.50752552747237 10.2336645113117 6.78138654363301 0.662654764198811 -0.593670656978249 0.583808035907083 1 0.0758186 0.158184 0.0472726 0.0663618 GeneID:105371566,Genbank:XM_024451066.1 uncharacterized LOC105371566 LOC105371727 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0709338 0.0658211 GeneID:105371727,Genbank:XM_017025511.1 uncharacterized LOC105371727 GO:0000122,GO:0000790,GO:0001892,GO:0005634,GO:0005654,GO:0005737,GO:0006338,GO:0006351,GO:0006355,GO:0007420,GO:0007492,GO:0008134,GO:0009611,GO:0009952,GO:0016569,GO:0016589,GO:0030425,GO:0043565,GO:0044297,GO:0045893,GO:0046872,GO:0048471,GO:0070062,GO:1990090 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|embryonic placenta development|nucleus|nucleoplasm|cytoplasm|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|brain development|endoderm development|transcription factor binding|response to wounding|anterior/posterior pattern specification|covalent chromatin modification|NURF complex|dendrite|sequence-specific DNA binding|cell body|positive regulation of transcription, DNA-templated|metal ion binding|perinuclear region of cytoplasm|extracellular exosome|cellular response to nerve growth factor stimulus LOC105371763 55.2928642253451 56.3189766046649 54.2667518460252 0.963560688024476 -0.0535525601207261 0.909547875939966 1 0.674261 1.16694 0.619722 1.07037 GeneID:105371763,Genbank:XM_017025495.1 uncharacterized LOC105371763 LOC105371921 10.5865814585929 12.9339615496312 8.23920136755471 0.637020709852787 -0.650587818926612 0.609343970669337 1 0 0.166627 0.0389211 0.0365672 GeneID:105371921,Genbank:XM_017025502.1 uncharacterized LOC105371921 LOC105371930 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0638071 0 0 0 GeneID:105371930,Genbank:XM_011525587.1 uncharacterized LOC105371930 LOC105371932 11.8814920579252 10.6757096385841 13.0872744772662 1.22589269662845 0.293832704300342 0.779814048821418 1 0.0481577 0.422443 0.534246 0.291121 GeneID:105371932,Genbank:XM_017025492.2 uncharacterized LOC105371932 LOC105371933 6.19138312511396 7.05310472614284 5.32966152408509 0.75564758089162 -0.404214548064257 0.773258613493264 1 0.24602 0.54396 0.226477 0.319162 GeneID:105371933,Genbank:XM_017025493.1 uncharacterized LOC105371933 LOC105371944 1.50943087342164 1.56626675524197 1.45259499160132 0.927425029446474 -0.108697432040536 1 1 0.222395 0.0967976 0 0.28958 GeneID:105371944,Genbank:XM_011523611.2 uncharacterized LOC105371944 LOC105372269 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0281078 0.0143236 0 GeneID:105372269,Genbank:XM_011528461.2 endogenous retrovirus group K member 8 Gag polyprotein-like GO:0003723,GO:0003887,GO:0003964,GO:0004190,GO:0004523,GO:0005198,GO:0005886,GO:0008270,GO:0016032,GO:0019028 RNA binding|DNA-directed DNA polymerase activity|RNA-directed DNA polymerase activity|aspartic-type endopeptidase activity|RNA-DNA hybrid ribonuclease activity|structural molecule activity|plasma membrane|zinc ion binding|viral process|viral capsid LOC105372412 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0 0.0108923 0 0.0105742 GeneID:105372412,Genbank:XM_017027562.1 phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein-like LOC105372704 1.49172579352946 2.49838328447175 0.48506830258717 0.194152877023323 -2.3647350091371 0.504995494363966 1 0.0267618 0.0715489 0.0249787 0 GeneID:105372704,Genbank:XM_011529123.2 uncharacterized LOC105372704 LOC105372824 2.76155905136932 4.55472144167109 0.968396661067546 0.212613806018453 -2.23369281397478 0.297621909191535 1 0.119833 0.307262 0 0.103206 GeneID:105372824,Genbank:XM_011529811.1 uncharacterized LOC105372824 LOC105372836 1.24375355683899 1.51824048055703 0.969266633120943 0.638414431398462 -0.647434830746163 0.97445271569056 1 0 0 0 0 GeneID:105372836,Genbank:XM_011529812.2 uncharacterized LOC105372836 LOC105372883 1.02229600717608 1.07619535328461 0.968396661067546 0.899833527539349 -0.152269972565186 1 1 0.0198492 0 0 0.0175914 GeneID:105372883,Genbank:XM_011510292.2 uncharacterized LOC105372883 LOC105373102 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:105373102,Genbank:XM_011546186.1 uncharacterized LOC105373102 LOC105373132 44.7929937425533 45.47957083181 44.1064166532966 0.969807230952298 -0.0442300842752786 0.966679206586052 1 1.52759 1.12224 1.37404 0.949703 GeneID:105373132,Genbank:XM_024451877.1 uncharacterized LOC105373132 LOC105373244 2.45348777759512 1.02816907859967 3.87880647659057 3.77253756928129 1.91553526808023 0.422201140703971 1 0.0154633 0.0139792 0.0581325 0.0271568 GeneID:105373244,Genbank:XM_011531082.2 uncharacterized LOC105373244 GO:0005737,GO:0005884,GO:0005886,GO:0006629,GO:0008889,GO:0016021,GO:0030027,GO:0045669,GO:0046872,GO:0047394,GO:0090527 cytoplasm|actin filament|plasma membrane|lipid metabolic process|glycerophosphodiester phosphodiesterase activity|integral component of membrane|lamellipodium|positive regulation of osteoblast differentiation|metal ion binding|glycerophosphoinositol inositolphosphodiesterase activity|actin filament reorganization LOC105373289 1.0016543915721 1.51824048055703 0.48506830258717 0.319493722370782 -1.64614051048666 0.791481013618379 1 0 0.0265139 0 0 GeneID:105373289,Genbank:XM_024451572.1 collagen alpha-1(III) chain-like LOC105373311 28.7176007930684 38.532327310145 18.9028742759919 0.490571828787902 -1.02746370574301 0.054210169544311 0.849526737634191 0.818648 0.780027 0.413416 0.364195 GeneID:105373311,Genbank:XM_011531090.3 translation initiation factor IF-2 LOC105373314 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0 0 0 GeneID:105373314,Genbank:XM_011537536.2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 GO:0016757 transferase activity, transferring glycosyl groups LOC105373750 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0.0196002 0.0180948 0 0.0173246 GeneID:105373750,Genbank:XM_017005447.1 uncharacterized LOC105373750 LOC105373759 4.99108772961643 4.65077399104097 5.33140146819188 1.14634714102686 0.197043992437241 0.959668934535163 1 0.0845131 0.0318234 0.0641543 0.0149625 GeneID:105373759,Genbank:XM_017005483.2 uncharacterized LOC105373759 GO:0005829,GO:0016020,GO:0042803,GO:0070062 cytosol|membrane|protein homodimerization activity|extracellular exosome LOC105373780 4.19024927210326 4.01662376502878 4.36387477917774 1.08645345804413 0.119626373058429 1 1 0.0359373 0.104871 0.121722 0.0322961 GeneID:105373780,Genbank:XM_011512285.1 proline-rich protein 18-like LOC105373926 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00607384 0 0 GeneID:105373926,Genbank:XM_011512292.1 endogenous retrovirus group K member 18 Pol protein GO:0003677,GO:0003723,GO:0003887,GO:0003964,GO:0004190,GO:0004523,GO:0006308,GO:0006310,GO:0008270,GO:0016020,GO:0019013,GO:0019068,GO:0020002,GO:0032993,GO:0039657,GO:0039660,GO:0039705,GO:0044185,GO:0044824,GO:0044826,GO:0046718,GO:0072494,GO:0075713 DNA binding|RNA binding|DNA-directed DNA polymerase activity|RNA-directed DNA polymerase activity|aspartic-type endopeptidase activity|RNA-DNA hybrid ribonuclease activity|DNA catabolic process|DNA recombination|zinc ion binding|membrane|viral nucleocapsid|virion assembly|host cell plasma membrane|protein-DNA complex|suppression by virus of host gene expression|structural constituent of virion|viral translational readthrough|host cell late endosome membrane|retroviral 3' processing activity|viral genome integration into host DNA|viral entry into host cell|host multivesicular body|establishment of integrated proviral latency LOC105373944 6.20452009166265 5.14084539299833 7.26819479032697 1.41381314447348 0.499591460066116 0.726076734222235 1 0.0299638 0.128734 0.0548851 0.154485 GeneID:105373944,Genbank:XM_017005449.1 translation initiation factor IF-2-like LOC105373989 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0 0.055924 GeneID:105373989,Genbank:XM_017005445.1 putative cuticle collagen 91 LOC105374013 15.5123262978253 9.69556683466942 21.3290857609811 2.19988022615785 1.13742497746265 0.125205153314746 1 0.0265291 0.0767816 0.17958 0.0873789 GeneID:105374013,Genbank:XM_011513341.3 endogenous retrovirus group K member 5 Gag polyprotein GO:0003676,GO:0005198,GO:0005886,GO:0008270,GO:0016032,GO:0019028 nucleic acid binding|structural molecule activity|plasma membrane|zinc ion binding|viral process|viral capsid LOC105374089 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0165805 0 0 GeneID:105374089,Genbank:XM_011513342.2 uncharacterized LOC105374089 GO:0003341,GO:0031514,GO:0036159,GO:0070840,GO:0097545,GO:2000574 cilium movement|motile cilium|inner dynein arm assembly|dynein complex binding|axonemal outer doublet|regulation of microtubule motor activity LOC105374103 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0 0 GeneID:105374103,Genbank:XM_011513345.2 uncharacterized LOC105374103 GO:0003677,GO:0003723,GO:0003887,GO:0003964,GO:0004190,GO:0004523,GO:0006310,GO:0008270,GO:0015074,GO:0016020,GO:0019013,GO:0019068,GO:0020002,GO:0039660,GO:0042802,GO:0044826,GO:0046718,GO:0075713 DNA binding|RNA binding|DNA-directed DNA polymerase activity|RNA-directed DNA polymerase activity|aspartic-type endopeptidase activity|RNA-DNA hybrid ribonuclease activity|DNA recombination|zinc ion binding|DNA integration|membrane|viral nucleocapsid|virion assembly|host cell plasma membrane|structural constituent of virion|identical protein binding|viral genome integration into host DNA|viral entry into host cell|establishment of integrated proviral latency LOC105374301 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0 0 0 0 GeneID:105374301,Genbank:XM_017007605.2 mucin-1-like GO:0016021 integral component of membrane LOC105374378 1.58777834289935 2.69048838321152 0.48506830258717 0.180290056487129 -2.47160826468559 0.581421154271302 1 0.018834 0 0.00895555 0 GeneID:105374378,Genbank:XM_011533218.2 uncharacterized LOC105374378 LOC105374811 25.7116448535025 27.6645125728211 23.758777134184 0.858817847292407 -0.21957592239968 0.795069146731818 1 0.474918 0.498593 0.846119 0.237017 GeneID:105374811,Genbank:XM_017005462.1 uncharacterized LOC105374811 LOC105375106 1.51530394484523 2.54640955915669 0.484198330533773 0.190149431693984 -2.39479446774372 0.50238275309926 1 0 0.268456 0 0.0876048 GeneID:105375106,Genbank:XM_011515047.2 uncharacterized LOC105375106 LOC105375116 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0119531 GeneID:105375116,Genbank:XM_017012903.2 TRIO and F-actin-binding protein-like LOC105375131 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00930119 0 0 0 GeneID:105375131,Genbank:XM_011515667.2 basic proline-rich protein-like LOC105375683 1.99787069774731 2.05633815719933 1.93940323829528 0.943134392320322 -0.0844647319197664 1 1 0 0.045837 0.0489479 0.0456815 GeneID:105375683,Genbank:XM_024447366.1 uncharacterized LOC105375683 LOC105375787 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0 0 GeneID:105375787,Genbank:NM_001317971.1 uncharacterized LOC105375787 LOC105376204 9.317812404903 6.51500704950053 12.1206177603055 1.86041514125985 0.89562458660686 0.438700996723219 1 0.012526 0.0555309 0.103293 0.0283228 GeneID:105376204,Genbank:XM_017015409.2 uncharacterized LOC105376204 GO:0016021 integral component of membrane LOC105376335 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:105376335,Genbank:XM_011519284.2 serine/arginine repetitive matrix protein 1-like LOC105376353 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0164931 0 0 0 GeneID:105376353,Genbank:XM_017017015.1 mucin-5AC-like LOC105376678 1.99700072569391 2.05633815719933 1.93766329418849 0.942288255170796 -0.0857596330424504 1 1 0 0 0 0 GeneID:105376678,Genbank:XM_011520903.3 ovostatin-like GO:0004867,GO:0005615 serine-type endopeptidase inhibitor activity|extracellular space LOC105376684 11.7690297920843 12.8761266198383 10.6619329643304 0.828038841114182 -0.272229652563071 0.794762006117461 1 0.347065 0.296741 0.225012 0.192167 GeneID:105376684,Genbank:XM_011521137.3 translation initiation factor IF-2-like GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding LOC105376714 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:105376714,Genbank:XM_017022774.1 uncharacterized LOC105376714 LOC105376722 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0.0257505 0 0 0 GeneID:105376722,Genbank:XM_017022777.2 uncharacterized LOC105376722 LOC105376791 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0153513 GeneID:105376791,Genbank:XM_011523610.2 uncharacterized LOC105376791 LOC105376875 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0126267 0 0 GeneID:105376875,Genbank:XM_017026112.1 uncharacterized LOC105376875 LOC105377022 3.51317464259254 4.60274771635603 2.42360156882906 0.526555379130753 -0.925342823853329 0.631893242266506 1 0.0795645 0.0926113 0.0566275 0.0353143 GeneID:105377022,Genbank:XM_017007616.1 uncharacterized LOC105377022 LOC105377310 0.971768182806039 0.490071401957362 1.45346496365472 2.96582285326082 1.56843242909583 0.837471602739444 1 0 0.0285207 0 0 GeneID:105377310,Genbank:XM_011532442.2 syncytin-1-like GO:0005886,GO:0006949,GO:0016021,GO:0019031 plasma membrane|syncytium formation|integral component of membrane|viral envelope LOC105377622 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0 0.0118122 0 0 GeneID:105377622,Genbank:XM_017008887.2 uncharacterized LOC105377622 LOC105377641 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.00937663 0.00883783 0 0 GeneID:105377641,Genbank:XM_024453866.1 endogenous retrovirus group PABLB member 1 Env polyprotein GO:0005886,GO:0016021 plasma membrane|integral component of membrane LOC105377650 1.99787069774731 2.05633815719933 1.93940323829528 0.943134392320322 -0.0844647319197664 1 1 0.0163485 0.0295696 0.0462593 0.0144376 GeneID:105377650,Genbank:XM_017007608.1 uncharacterized LOC105377650 LOC105377805 2.19281356038265 1.96028560782945 2.42534151293585 1.23723885093527 0.307124041782309 1 1 0 0.0215363 0.0225436 0 GeneID:105377805,Genbank:XM_017020908.2 basic salivary proline-rich protein 4-like LOC105378148 0.972203168832738 0.490071401957362 1.45433493570811 2.96759804775273 1.56929569647876 0.837430708298891 1 0 0.0233662 0.0237857 0 GeneID:105378148,Genbank:XM_017011621.1 uncharacterized LOC105378148 GO:0003964,GO:0004519,GO:0006310,GO:0046872 RNA-directed DNA polymerase activity|endonuclease activity|DNA recombination|metal ion binding LOC105378161 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0500618 0 GeneID:105378161,Genbank:XM_011536308.2 uncharacterized LOC105378161 LOC105378189 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0114103 0 GeneID:105378189,Genbank:XM_011537451.3 uncharacterized LOC105378189 GO:0003723,GO:0003735,GO:0006412,GO:0019843,GO:0022625,GO:0046872 RNA binding|structural constituent of ribosome|translation|rRNA binding|cytosolic large ribosomal subunit|metal ion binding LOC105378230 0.996651292201907 0.538097676642304 1.45520490776151 2.70435084730694 1.43528233092293 0.835161298535314 1 0 0 0 0 GeneID:105378230,Genbank:XM_017010135.1 synapsin-1-like LOC105378592 1.02316597922947 1.07619535328461 0.97013660517434 0.901450282435646 -0.149680169798226 1 1 0.0680021 0.0435486 0.0312703 0 GeneID:105378592,Genbank:XM_017003076.2 uncharacterized LOC105378592 LOC105378862 13.5647795976926 14.0483745224928 13.0811846728924 0.931152899714356 -0.102910010295674 0.969193066761022 1 0.505207 0.117469 0.200109 0.298531 GeneID:105378862,Genbank:XM_011542527.2 translation initiation factor IF-2-like LOC105378947 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0 0 0 GeneID:105378947,Genbank:XM_011542538.1 proline-rich extensin-like protein EPR1 LOC105378949 7.92117372840974 9.54167935550665 6.30066810131283 0.660331149953872 -0.598738390745037 0.717041138333642 1 0.693851 0.136303 0.195998 0.0922484 GeneID:105378949,Genbank:XM_017003073.1 collagen alpha-2(VIII) chain LOC105378950 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0240227 GeneID:105378950,Genbank:XM_011542544.2 mitogen-activated protein kinase 7-like LOC105379045 15.1987680002076 19.247054845284 11.1504811551311 0.579334409589593 -0.787531738405218 0.278941847269843 1 0.101047 0.181108 0.113138 0.0491493 GeneID:105379045,Genbank:XM_011543774.2 uncharacterized LOC105379045 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding LOC105379177 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.0159938 0 0.0306915 0 GeneID:105379177,Genbank:XM_011543785.2 uncharacterized LOC105379177 LOC105379282 2.58606121273295 3.71865746181119 1.45346496365472 0.390857447501174 -1.3552855673609 0.583356108377211 1 0.0485229 0.00895482 0.00922943 0.0172117 GeneID:105379282,Genbank:XM_011544346.3 glucose-dependent insulinotropic receptor-like LOC105379356 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:105379356,Genbank:XM_017014156.1 uncharacterized LOC105379356 GO:0003677,GO:0003723,GO:0003887,GO:0003964,GO:0004190,GO:0004523,GO:0006310,GO:0008270,GO:0015074,GO:0016020,GO:0019013,GO:0019068,GO:0020002,GO:0039660,GO:0042802,GO:0044826,GO:0046718,GO:0075713 DNA binding|RNA binding|DNA-directed DNA polymerase activity|RNA-directed DNA polymerase activity|aspartic-type endopeptidase activity|RNA-DNA hybrid ribonuclease activity|DNA recombination|zinc ion binding|DNA integration|membrane|viral nucleocapsid|virion assembly|host cell plasma membrane|structural constituent of virion|identical protein binding|viral genome integration into host DNA|viral entry into host cell|establishment of integrated proviral latency LOC105379752 2.48293900033448 2.05633815719933 2.90953984346962 1.41491312276786 0.500713472703931 0.908148744105114 1 0.0122244 0.00570152 0.0291179 0.00546608 GeneID:105379752,Genbank:XM_017012937.1 putative uncharacterized protein FLJ46204 GO:0005654 nucleoplasm LOC107983990 6.8567116117775 4.50669516698614 9.20672805656886 2.04290011093115 1.030618664185 0.402437923046962 1 0.0434972 0.141831 0.165824 0.212575 GeneID:107983990,Genbank:XM_005255752.3 uncharacterized LOC107983990 GO:0005634 nucleus LOC107983998 41.3766074425193 31.8732414365897 50.879973448449 1.59632253122646 0.674752172356158 0.128067798376892 1 1.05537 0.700373 1.2229 1.79892 GeneID:107983998,Genbank:XM_011527018.2 uncharacterized LOC107983998 LOC107984025 2.69134544907011 0.538097676642304 4.84459322149792 9.00318554008238 3.17043555141328 0.177739667555652 1 0 0 0 0 GeneID:107984025,Genbank:XM_017022772.1 golgin subfamily A member 8M-like GO:0005794 Golgi apparatus LOC107984026 20.8003065318505 20.765295325841 20.83531773786 1.00337208842543 0.00485671121336319 1 1 0.110695 0.179077 0.122333 0.146701 GeneID:107984026,Genbank:XM_017017033.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4-like LOC107984104 3.50480002148386 3.13253351048394 3.87706653248377 1.2376775921177 0.307635549745768 0.933228454855853 1 0.0138289 0 0 0.006106 GeneID:107984104,Genbank:XM_017028191.1 uncharacterized LOC107984104 GO:0003964,GO:0006310,GO:0009036,GO:0032197,GO:0032199,GO:0046872,GO:0090305 RNA-directed DNA polymerase activity|DNA recombination|Type II site-specific deoxyribonuclease activity|transposition, RNA-mediated|reverse transcription involved in RNA-mediated transposition|metal ion binding|nucleic acid phosphodiester bond hydrolysis LOC107984110 17.2666974119453 17.0848554836069 17.4485393402838 1.02128691442698 0.0303882255418378 0.997890058330554 1 0.0945114 0.0430785 0.0559939 0.0417763 GeneID:107984110,Genbank:XM_017005470.2 fumarylacetoacetate hydrolase domain-containing protein 2B-like GO:0008152,GO:0016787,GO:0046872 metabolic process|hydrolase activity|metal ion binding LOC107984115 49.3062977741517 46.2774171920929 52.3351783562105 1.13090102109572 0.17747266706151 0.705014590860284 1 0.611144 0.8081 0.639519 0.770166 GeneID:107984115,Genbank:XM_017010109.1 laforin-like LOC107984124 2.75448938834073 3.084507235799 2.42447154088245 0.786015838362729 -0.347369711541969 0.960571001096806 1 0.46266 0 0 0 GeneID:107984124,Genbank:XM_017014154.1 translation initiation factor IF-2-like LOC107984125 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0 0 0 GeneID:107984125,Genbank:XM_017014157.1 lipoxygenase homology domain-containing protein 1-like GO:0005262,GO:0007605,GO:0016020,GO:0032420,GO:0050982 calcium channel activity|sensory perception of sound|membrane|stereocilium|detection of mechanical stimulus LOC107984138 52.9554431860102 63.7464828731793 42.1644034988411 0.661438899817034 -0.596320200669428 0.133869188380691 1 0.509332 0.435154 0.3943 0.220082 GeneID:107984138,Genbank:XM_017023966.2 serine/threonine-protein kinase SMG1-like GO:0000184,GO:0003723,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006406,GO:0006950,GO:0018105,GO:0032204,GO:0042162,GO:0046777,GO:0046854,GO:0046872 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|mRNA export from nucleus|response to stress|peptidyl-serine phosphorylation|regulation of telomere maintenance|telomeric DNA binding|protein autophosphorylation|phosphatidylinositol phosphorylation|metal ion binding LOC107984139 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0236976 0 GeneID:107984139,Genbank:XM_017027560.1 zinc finger protein 791-like LOC107984159 1.97679409611663 2.49838328447175 1.45520490776151 0.582458631069969 -0.77977250841594 0.825694118379557 1 0.0118357 0.0439578 0.0225546 0 GeneID:107984159,Genbank:XM_017017009.2 uncharacterized LOC107984159 GO:0000028,GO:0000184,GO:0003723,GO:0003735,GO:0005654,GO:0005730,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0031012,GO:0070062 ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleoplasm|nucleolus|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|extracellular matrix|extracellular exosome LOC107984208 0.975139704544532 0.980142803914724 0.97013660517434 0.989791080748215 -0.0148040531050533 1 1 0 0 0 0 GeneID:107984208,Genbank:XM_017017017.1 putative uncharacterized protein LOC439951 GO:0005615 extracellular space LOC107984236 3.96629017275525 3.084507235799 4.84807310971151 1.57174963100895 0.652371424422799 0.737405021966803 1 0.231856 0.198401 0.35648 0.200309 GeneID:107984236,Genbank:XM_017017025.2 translation initiation factor IF-2-like LOC107984264 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0171364 0 0 0 GeneID:107984264,Genbank:XM_017017026.1 transmembrane protein 108-like GO:0003723,GO:0003887,GO:0003964,GO:0004190,GO:0004523,GO:0005198,GO:0005886,GO:0008270,GO:0016032,GO:0019028 RNA binding|DNA-directed DNA polymerase activity|RNA-directed DNA polymerase activity|aspartic-type endopeptidase activity|RNA-DNA hybrid ribonuclease activity|structural molecule activity|plasma membrane|zinc ion binding|viral process|viral capsid LOC107984282 16.6457925189569 13.4142242964806 19.8773607414332 1.48181216461755 0.567362582360739 0.476076936030566 1 0.0560948 0.0288405 0.113167 0.0408076 GeneID:107984282,Genbank:XM_024448276.1 uncharacterized LOC107984282 LOC107984314 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0.893934 1.37033 0.63017 0.408587 GeneID:107984314,Genbank:XM_017018639.2 uncharacterized LOC107984314 LOC107984449 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:107984449,Genbank:XM_024449289.1 uncharacterized LOC107984449 LOC107984507 5.3948720270141 3.03648096111406 7.75326309291415 2.5533712189223 1.35240329754363 0.329987660236127 1 0.0244353 0.0431093 0.0795404 0.0638834 GeneID:107984507,Genbank:XM_017020292.2 collagen alpha-1(I) chain-like GO:0005654 nucleoplasm LOC107984512 1.04968066625704 1.61429302992691 0.48506830258717 0.300483427478549 -1.73464267051938 0.787636841365487 1 0.0260872 0 0.0122303 0 GeneID:107984512,Genbank:XM_017020293.1 uncharacterized LOC107984512 LOC107984590 12.7799287768185 15.8645813062674 9.69527624736962 0.611127142923049 -0.71045553582141 0.388819201685663 1 0.124911 0.192908 0.113988 0.0765905 GeneID:107984590,Genbank:XM_017020903.1 proline-rich extensin-like protein EPR1 LOC107984638 92.0319784168957 84.7136919528681 99.3502648809233 1.1727769453868 0.229928648162256 0.47911669198356 1 3.76141 3.84583 4.97471 4.39925 GeneID:107984638,Genbank:XM_024449798.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 LOC107984648 43.8552223949764 43.6153377733505 44.0951070166024 1.01100001209999 0.0157830145075882 0.968916990782456 1 0.360467 0.248473 0.500055 0.334547 GeneID:107984648,Genbank:XM_017021849.1 uncharacterized LOC107984648 LOC107984745 4.4727616965247 3.13253351048394 5.81298988256547 1.85568322353475 0.891950454624631 0.571491692634774 1 0.0439052 0.0203949 0.0312381 0.0486518 GeneID:107984745,Genbank:XM_017022786.1 uncharacterized mitochondrial protein AtMg00860-like GO:0003677,GO:0003723,GO:0003887,GO:0003964,GO:0004190,GO:0004523,GO:0006310,GO:0015074,GO:0016020,GO:0019013,GO:0020002,GO:0039660,GO:0044185,GO:0044826,GO:0046718,GO:0046872,GO:0072494,GO:0075713 DNA binding|RNA binding|DNA-directed DNA polymerase activity|RNA-directed DNA polymerase activity|aspartic-type endopeptidase activity|RNA-DNA hybrid ribonuclease activity|DNA recombination|DNA integration|membrane|viral nucleocapsid|host cell plasma membrane|structural constituent of virion|host cell late endosome membrane|viral genome integration into host DNA|viral entry into host cell|metal ion binding|host multivesicular body|establishment of integrated proviral latency LOC107984813 5.75858259100363 7.63922867747008 3.87793650453717 0.507634562108886 -0.978137797013276 0.456516916538408 1 0.182572 0.193328 0.143001 0.0531599 GeneID:107984813,Genbank:XM_024450502.1 uncharacterized LOC107984813 LOC107984814 18.2915904290868 13.3181717471107 23.2650091110628 1.74686207332549 0.804765702138606 0.235336368885547 1 0.236464 0.216292 0.634498 0.347584 GeneID:107984814,Genbank:XM_017023920.1 uncharacterized LOC107984814 LOC107984817 4.18274462304797 2.54640955915669 5.81907968693925 2.28520964587738 1.19232652466783 0.492206293251025 1 0.0246759 0.064488 0.183465 0.0428847 GeneID:107984817,Genbank:XM_017023972.1 uncharacterized LOC107984817 LOC107984820 1.78185123348129 2.59443583384164 0.969266633120943 0.373594374729911 -1.42045536256559 0.670799861503385 1 0 0.022158 0 0.0107877 GeneID:107984820,Genbank:XM_017023964.1 uncharacterized LOC107984820 LOC107984833 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0464099 0 0 0 GeneID:107984833,Genbank:XM_017023985.1 translation initiation factor IF-2-like LOC107984841 3.48165685619478 3.084507235799 3.87880647659057 1.25751252309376 0.330572767359077 0.933597067572996 1 0 0 0 0 GeneID:107984841,Genbank:XM_017003008.1 uncharacterized LOC107984841 LOC107984862 5.54462969039601 8.66739775606975 2.42186162472226 0.279422001029806 -1.83948247526037 0.167997343773769 1 0.0841413 0.0738905 0 0.0418343 GeneID:107984862,Genbank:XM_017023969.1 uncharacterized LOC107984862 LOC107984876 0.780631827935889 1.07619535328461 0.48506830258717 0.450725141217823 -1.14968016979823 0.981241458110389 1 0.0257506 0 0.0117504 0 GeneID:107984876,Genbank:XM_017023922.1 uncharacterized LOC107984876 GO:0005654 nucleoplasm LOC107984974 103.880383850356 113.252486125126 94.5082815755856 0.834491893371497 -0.261030060218059 0.375395194411083 1 0.287826 0.354363 0.282419 0.279318 GeneID:107984974,Genbank:XM_024450545.1 uncharacterized LOC107984974 GO:0000278,GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006974,GO:0007346,GO:0023014,GO:0030145,GO:0031098,GO:0032147,GO:0035253,GO:0035869,GO:0036064,GO:0042981,GO:0045893,GO:0051301,GO:0097014,GO:1900062,GO:2000772,GO:2001020 mitotic cell cycle|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|cellular response to DNA damage stimulus|regulation of mitotic cell cycle|signal transduction by protein phosphorylation|manganese ion binding|stress-activated protein kinase signaling cascade|activation of protein kinase activity|ciliary rootlet|ciliary transition zone|ciliary basal body|regulation of apoptotic process|positive regulation of transcription, DNA-templated|cell division|ciliary plasm|regulation of replicative cell aging|regulation of cellular senescence|regulation of response to DNA damage stimulus LOC107985021 3.04961792766275 4.16070258908361 1.93853326624189 0.465914884502438 -1.10186167417518 0.61087732440401 1 0.0280145 0.0130198 0.0088958 0.00828569 GeneID:107985021,Genbank:XM_017025504.2 flocculation protein FLO11-like LOC107985082 1.48335117242078 1.02816907859967 1.93853326624189 1.88542264749112 0.914887962799843 0.868258168018795 1 0.0402492 0.0374098 0.0758873 0.070937 GeneID:107985082,Genbank:XM_017025510.1 leucine-rich repeat-containing protein 37A3-like GO:0016021 integral component of membrane LOC107985103 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0250711 0 GeneID:107985103,Genbank:XM_024451517.1 translation initiation factor IF-2-like LOC107985115 27.9598584702966 28.2986627988333 27.62105414176 0.976055099780147 -0.0349655024928442 0.992760326414227 1 0.0930784 0.156344 0.174907 0.19857 GeneID:107985115,Genbank:XM_017003072.1 translation initiation factor IF-2-like LOC107985184 3.19947105132494 4.4586688923012 1.94027321034868 0.435168714523511 -1.2003532538878 0.601701178479741 1 0 0.0599716 0.0492537 0 GeneID:107985184,Genbank:XM_017003082.1 protein enabled homolog GO:0005634,GO:0010468,GO:0046872,GO:0051213,GO:0071558 nucleus|regulation of gene expression|metal ion binding|dioxygenase activity|histone demethylase activity (H3-K27 specific) LOC107985246 58.9567058471606 53.95486348914 63.9585482051813 1.18540839637292 0.24538418141576 0.520302463271332 1 0.400919 0.332187 0.341144 0.452587 GeneID:107985246,Genbank:XM_017003087.1 translation initiation factor IF-2 LOC107985320 2.47619595685749 1.07619535328461 3.87619656043037 3.60175924250184 1.84870174835767 0.420368655579507 1 0.0171948 0 0.031904 0.0149188 GeneID:107985320,Genbank:XM_017027553.1 uncharacterized LOC107985320 LOC107985381 2.29299923706933 3.13253351048394 1.45346496365472 0.463990236270504 -1.10783364779385 0.696599143132555 1 0 0 0 0 GeneID:107985381,Genbank:XM_017028185.2 uncharacterized LOC107985381 LOC107985388 28.9196397563253 22.4658322500299 35.3734472626207 1.57454426210156 0.654934313724114 0.205970353825901 1 0.924653 0.462155 1.03773 1.15087 GeneID:107985388,Genbank:XM_017028186.1 pre-mRNA-splicing factor cwc22-like LOC107985410 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0215703 GeneID:107985410,Genbank:XM_017028198.1 uncharacterized LOC107985410 LOC107985416 2.26604956401506 2.59443583384164 1.93766329418849 0.746853427212863 -0.42110295840788 0.964656809965331 1 0.194828 0.165902 0.0891474 0.166834 GeneID:107985416,Genbank:XM_017028193.1 translation initiation factor IF-2-like LOC107985476 14.4199619819999 14.2983145510254 14.5416094129743 1.01701563223278 0.0243418545851755 1 1 0.147126 0.156869 0.205591 0.128869 GeneID:107985476,Genbank:XM_017028526.2 putative uncharacterized protein encoded by LINC00205 LOC107985524 3.77297888775161 3.67063118712625 3.87532658837698 1.05576572279139 0.0782897323622989 1 1 0.0431719 0.0166604 0.00833021 0.0387252 GeneID:107985524,Genbank:XM_024452028.1 uncharacterized LOC107985524 GO:0016021 integral component of membrane LOC107985532 40.1649648579495 46.4116873610398 33.9182423548592 0.730812523384612 -0.452426738330184 0.329562300032553 1 0.616757 0.43395 0.270205 0.347942 GeneID:107985532,Genbank:XM_017029165.1 uncharacterized LOC107985532 LOC107985657 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0209118 0 0 0.0184726 GeneID:107985657,Genbank:XM_017030004.1 uncharacterized LOC107985657 LOC107985678 3.02473481826688 4.11267631439867 1.93679332213509 0.470932593298016 -1.08640751970762 0.611816776500908 1 0.110024 0.102395 0 0.0244293 GeneID:107985678,Genbank:XM_017030007.1 uncharacterized LOC107985678 LOC107985687 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.0132203 0 0.0122619 0 GeneID:107985687,Genbank:XM_017030006.1 translation initiation factor IF-2-like LOC107985692 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:107985692,Genbank:XM_017030017.1 A-kinase anchor protein 17B-like GO:0003723,GO:0005681,GO:0006397,GO:0008380,GO:0016607 RNA binding|spliceosomal complex|mRNA processing|RNA splicing|nuclear speck LOC107985728 71.1418061204557 60.3836266443786 81.8999855965328 1.35632770252227 0.439705790336778 0.221871328718352 1 0.594716 0.82487 0.822257 0.959628 GeneID:107985728,Genbank:XM_017003065.1 collagen alpha-1(III) chain-like LOC107985734 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 3.83066e-10 0 0.0492463 0 GeneID:107985734,Genbank:XM_017003077.1 uncharacterized LOC107985734 LOC107985770 39.1571837348288 34.707808643856 43.6065588258017 1.25639043574481 0.329284865647839 0.522657708802076 1 0.0276295 0 0.0175827 0 GeneID:107985770,Genbank:XM_017005435.1 natural cytotoxicity triggering receptor 3 ligand 1-like GO:0005198,GO:0005886,GO:0016021,GO:0019028,GO:0050776 structural molecule activity|plasma membrane|integral component of membrane|viral capsid|regulation of immune response LOC107985803 96.5550545163762 95.7157768591389 97.3943321736135 1.01753687186748 0.0250810735053303 0.939859589976102 1 2.35233 1.83399 1.73229 2.42835 GeneID:107985803,Genbank:XM_017005446.1 uncharacterized LOC107985803 LOC107985805 58.3411435792888 56.5973255976666 60.0849615609111 1.06162192164409 0.0862700666277211 0.831136636509433 1 1.45592 1.43455 1.47823 1.25945 GeneID:107985805,Genbank:XM_024453265.1 sine oculis-binding protein homolog LOC107985856 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0.031431 0 GeneID:107985856,Genbank:XM_017005458.1 uncharacterized LOC107985856 LOC107985876 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00918086 0 0 0.00812266 GeneID:107985876,Genbank:XM_017005460.1 uncharacterized LOC107985876 LOC107985911 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:107985911,Genbank:XM_017005465.2 uncharacterized LOC107985911 GO:0003779,GO:0004871,GO:0005886,GO:0006928,GO:0006968,GO:0015629,GO:0016020,GO:0070062 actin binding|signal transducer activity|plasma membrane|movement of cell or subcellular component|cellular defense response|actin cytoskeleton|membrane|extracellular exosome LOC107985939 26.7604795686862 34.6215647495941 18.8993943877783 0.545885043742856 -0.873330924481175 0.108495833118215 1 0.132742 0.190668 0.10688 0.0933282 GeneID:107985939,Genbank:XM_017005479.1 uncharacterized LOC107985939 GO:0005654 nucleoplasm LOC107985946 10.692399452773 10.7237359132691 10.661062992277 0.994155682170934 -0.00845630315109871 1 1 0.0560666 0.0867402 0.14156 0.11594 GeneID:107985946,Genbank:XM_017005480.2 uncharacterized LOC107985946 LOC107985971 17.857389476616 19.2372461901761 16.477532763056 0.856543218304845 -0.223402053176988 0.799396015171317 1 0.381903 0.222109 0.271746 0.267172 GeneID:107985971,Genbank:XM_017005484.1 uncharacterized LOC107985971 LOC107986035 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0.83664 0.317529 0.1473 GeneID:107986035,Genbank:XM_017007607.1 basic proline-rich protein-like LOC107986084 10.3620549857632 7.14915727551272 13.5749526960136 1.89881858418621 0.92510207494638 0.322678418976594 1 0.166796 0.185808 0.774442 0.290121 GeneID:107986084,Genbank:XM_017007618.1 Sjoegren syndrome nuclear autoantigen 1 homolog GO:0005634,GO:0005737,GO:0005813,GO:0036064,GO:0042073,GO:0042802,GO:0060830 nucleus|cytoplasm|centrosome|ciliary basal body|intraciliary transport|identical protein binding|ciliary receptor clustering involved in smoothened signaling pathway LOC107986113 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0133129 0 0 0 GeneID:107986113,Genbank:XM_017007620.2 endogenous retrovirus group K member 7 Gag polyprotein GO:0003676,GO:0005198,GO:0005886,GO:0008270,GO:0016032,GO:0019028 nucleic acid binding|structural molecule activity|plasma membrane|zinc ion binding|viral process|viral capsid LOC107986163 16.7177235645092 14.0483745224928 19.3870726065257 1.3800224770122 0.464691764981676 0.507566824400073 1 0.143533 0.0661217 0.145813 0.136328 GeneID:107986163,Genbank:XM_024453863.1 uncharacterized LOC107986163 GO:0003677,GO:0005634 DNA binding|nucleus LOC107986175 2.74905130294384 2.10436443188427 3.3937381740034 1.61271409200002 0.689490694777262 0.791542359355755 1 0.0677268 0.0295056 0.0929519 0.0580532 GeneID:107986175,Genbank:XM_017007622.1 uncharacterized LOC107986175 LOC107986211 25.3822706504886 27.020553691701 23.7439876092762 0.87873801107817 -0.186494993747492 0.797509922463504 1 0.0569645 0.051162 0.0530638 0.0608237 GeneID:107986211,Genbank:XM_024454317.1 translation initiation factor IF-2 GO:0005654,GO:0006351,GO:0006355,GO:0031519,GO:0036353,GO:0046872,GO:0060819 nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|PcG protein complex|histone H2A-K119 monoubiquitination|metal ion binding|inactivation of X chromosome by genetic imprinting LOC107986217 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0 0 0 GeneID:107986217,Genbank:XM_017008888.1 DNA-directed RNA polymerase II subunit 1-like LOC107986244 1.96885446103465 1.02816907859967 2.90953984346962 2.82982624553573 1.50071347270393 0.612176619732697 1 0 0 0 0.063032 GeneID:107986244,Genbank:XM_017008889.1 zinc finger protein 141-like GO:0003677,GO:0005634,GO:0006355,GO:0006366,GO:0009653,GO:0035108,GO:0046872 DNA binding|nucleus|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|anatomical structure morphogenesis|limb morphogenesis|metal ion binding LOC107986351 3.48122187016808 3.084507235799 3.87793650453717 1.25723047737725 0.330249151022823 0.933604022083919 1 0.0164554 0.029315 0.0305691 0.0287507 GeneID:107986351,Genbank:XM_017010104.1 putative POM121-like protein 1-like GO:0016021 integral component of membrane LOC107986453 5.70555321694849 6.56303332418548 4.84807310971151 0.738693965158739 -0.436951303443144 0.768949648864811 1 0.0259266 0.0714522 0.0409459 0.022959 GeneID:107986453,Genbank:XM_017010132.1 uncharacterized LOC107986453 LOC107986531 13.5137309216745 17.3347955121395 9.69266633120943 0.559145120830626 -0.838705325359226 0.286410349004457 1 0.0414688 0 0.0387655 0.03627 GeneID:107986531,Genbank:XM_024446613.1 translation initiation factor IF-2-like LOC107986532 1.74946347503013 1.07619535328461 2.42273159677566 2.25120057374467 1.17069460137475 0.729443551161772 1 0.138756 0 0.130019 0.180853 GeneID:107986532,Genbank:XM_017011596.1 FAM10 family protein At4g22670 GO:0005737,GO:0046983 cytoplasm|protein dimerization activity LOC107986554 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0 0.00709637 0 0 GeneID:107986554,Genbank:XM_017011610.2 uncharacterized LOC107986554 LOC107986596 10.9580767693557 10.771762187954 11.1443913507573 1.03459314792709 0.0490635417689943 1 1 0.190631 0.203485 0.176455 0.238573 GeneID:107986596,Genbank:XM_017011613.1 arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2-like LOC107986726 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0 0 0 0 GeneID:107986726,Genbank:XM_017012901.1 putative C-mannosyltransferase DPY19L2P2 GO:0000030,GO:0005634,GO:0005637,GO:0007275,GO:0007286,GO:0016021,GO:0018406 mannosyltransferase activity|nucleus|nuclear inner membrane|multicellular organism development|spermatid development|integral component of membrane|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan LOC107986752 25.303619062313 28.7887342007907 21.8185039238353 0.757883405767665 -0.399952176384123 0.570312246747162 1 0.283346 0.227403 0.219906 0.0881289 GeneID:107986752,Genbank:XM_017012904.1 enolase-phosphatase E1 LOC107986754 2.97214043023844 3.03648096111406 2.90779989936283 0.957621647097693 -0.062472330025007 1 1 0.0769478 0.0665035 0.141482 0.0662226 GeneID:107986754,Genbank:XM_017012905.1 MAPK-interacting and spindle-stabilizing protein-like LOC107986755 1.74902848900343 1.07619535328461 2.42186162472226 2.25039219629652 1.1701764549285 0.72947551930752 1 0 0 0.0053563 0.020128 GeneID:107986755,Genbank:XM_017012906.1 uncharacterized LOC107986755 LOC107986762 52.0706513791189 47.9299278415968 56.2113749166409 1.17278238144679 0.22993533533209 0.565294424714467 1 0.409696 0.351088 0.582626 0.784236 GeneID:107986762,Genbank:XM_017012909.1 uncharacterized LOC107986762 LOC107986777 1.4622745707901 1.47021420587209 1.45433493570811 0.989199349250911 -0.0156668042423989 1 1 0 0.0249416 0.02537 0.0118414 GeneID:107986777,Genbank:XM_017012910.1 uncharacterized LOC107986777 LOC107986791 6.33633192122219 7.34126237425249 5.33140146819188 0.726224073790135 -0.461513339684548 0.772289054478121 1 1.66726 1.22608 1.07962 1.27186 GeneID:107986791,Genbank:XM_024447032.1 uncharacterized LOC107986791 LOC107986794 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0 0 0 0 GeneID:107986794,Genbank:XM_017012923.2 putative uncharacterized protein FLJ46235 LOC107986797 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.00707852 GeneID:107986797,Genbank:XM_017012924.1 uncharacterized LOC107986797 LOC107986800 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0 0 0 GeneID:107986800,Genbank:XM_017012928.2 putative uncharacterized protein FLJ44672 LOC107986810 3.01929673286999 3.13253351048394 2.90605995525603 0.927702750993741 -0.108265475270541 1 1 0.0517499 0.015494 0.0161753 0.0757468 GeneID:107986810,Genbank:XM_017012934.1 uncharacterized LOC107986810 LOC107986838 39.5600346954054 40.3485340939196 38.7715352968911 0.960915586341805 -0.0575183949133665 0.916712829587667 1 0.0175254 0.0679207 0.0676297 0.0788537 GeneID:107986838,Genbank:XM_024447045.1 vegetative cell wall protein gp1-like LOC107986876 40.0609597673028 39.9064889666472 40.2154305679585 1.00774163824759 0.0111258124534105 1 1 0.260466 0.355081 0.30541 0.586358 GeneID:107986876,Genbank:XM_017014122.2 proline-rich proteoglycan 2-like LOC107986910 1.7764131480844 1.61429302992691 1.93853326624189 1.20085587331666 0.264063009221118 1 1 0.0744265 0 0 0 GeneID:107986910,Genbank:XM_017014151.1 uncharacterized LOC107986910 LOC107986982 1.24418854286568 1.51824048055703 0.97013660517434 0.638987444741564 -0.646140510486663 0.974454614671682 1 0.00857305 0.0155331 0.016196 0 GeneID:107986982,Genbank:XM_017014159.1 MAGE-like protein 2 LOC107987042 5.61416755273832 8.32140517816722 2.90692992730943 0.349331617085094 -1.5173308717148 0.259641663129255 1 0.0675989 0 0 0.044788 GeneID:107987042,Genbank:XM_017015393.2 phosphatidylinositol 4,5-bisphosphate 5-phosphatase A-like LOC107987096 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0149044 0 0 0 GeneID:107987096,Genbank:XM_017015400.2 translation initiation factor IF-2-like LOC107987098 7.40198731792349 6.56303332418548 8.24094131166151 1.25566044001221 0.328446378447517 0.835539910938306 1 0.0179373 0.0644685 0.0765461 0.0314222 GeneID:107987098,Genbank:XM_017015401.1 fibroin heavy chain-like LOC107987142 37.8988036159234 38.0040382886107 37.7935689432362 0.994461921552228 -0.00801196429039234 0.989033096843833 1 0.663253 1.2262 0.724249 1.14128 GeneID:107987142,Genbank:XM_017015414.1 translation initiation factor IF-2-like LOC107987158 10.8630025585143 10.0895856872569 11.6364194297717 1.15330993664769 0.205780270125185 0.902254230401306 1 0.0382903 0.0926556 0.0850807 0.0199039 GeneID:107987158,Genbank:XM_017018636.2 uncharacterized LOC107987158 GO:0005654 nucleoplasm LOC107987238 4.45549160265922 4.06465003971372 4.84633316560471 1.19231252832434 0.25376244382515 0.952415013963821 1 0 0 0 0 GeneID:107987238,Genbank:XM_017023970.1 proline-rich proteoglycan 2-like LOC107987243 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0.0478186 0 0 0 GeneID:107987243,Genbank:XM_024451053.1 uncharacterized LOC107987243 LOC107987254 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0209286 0 0 GeneID:107987254,Genbank:XM_017025513.2 uncharacterized protein FAM215A-like LOC107987269 1.73132340911125 2.00831188251439 1.45433493570811 0.72415791011867 -0.4656237687053 0.969069041887143 1 0.0627556 0.0825756 0.0302902 4.89742e-08 GeneID:107987269,Genbank:XM_017027568.1 uncharacterized LOC107987269 LOC107987276 0.974704718517834 0.980142803914724 0.969266633120943 0.98890348350226 -0.0160983733645535 1 1 0 0.0313012 0.0165158 0.0153926 GeneID:107987276,Genbank:XM_017028183.1 translation initiation factor IF-2 LOC107987289 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00953671 0 0 0 GeneID:107987289,Genbank:XM_017028511.1 helicase SRCAP-like LOC107987290 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0 0 0 0 GeneID:107987290,Genbank:XM_024452144.1 uncharacterized LOC107987290 LOC112267857 32.6395129990592 27.4724074740813 37.8066185240372 1.37616692529425 0.460655475627272 0.37654172788213 1 0.481812 0.870489 0.855497 0.294255 GeneID:112267857,Genbank:XM_017011345.1 uncharacterized LOC112267857 LOC112267874 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0 0 GeneID:112267874,Genbank:XM_024451970.1 translation initiation factor IF-2-like LOC112267904 1.74946347503013 1.07619535328461 2.42273159677566 2.25120057374467 1.17069460137475 0.729443551161772 1 0.0150674 0 0.0145972 0.00678213 GeneID:112267904,Genbank:XM_024448787.1 uncharacterized LOC112267904 LOC112267910 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0129969 0 0 0 GeneID:112267910,Genbank:XM_017030015.1 NACHT, LRR and PYD domains-containing protein 10-like GO:0002374,GO:0002674,GO:0002830,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005783,GO:0006351,GO:0006919,GO:0006954,GO:0008134,GO:0032088,GO:0032611,GO:0032621,GO:0032736,GO:0032753,GO:0032754,GO:0042347,GO:0042802,GO:0043565,GO:0044546,GO:0045087,GO:0045630,GO:0045944,GO:0050701,GO:0050713,GO:0050718,GO:0050830,GO:0051092,GO:0051607,GO:0071222,GO:0071224,GO:0072559,GO:2000321,GO:2000553 cytokine secretion involved in immune response|negative regulation of acute inflammatory response|positive regulation of type 2 immune response|ATP binding|extracellular region|nucleus|cytoplasm|endoplasmic reticulum|transcription, DNA-templated|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|transcription factor binding|negative regulation of NF-kappaB transcription factor activity|interleukin-1 beta production|interleukin-18 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-5 production|negative regulation of NF-kappaB import into nucleus|identical protein binding|sequence-specific DNA binding|NLRP3 inflammasome complex assembly|innate immune response|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|interleukin-1 secretion|negative regulation of interleukin-1 beta secretion|positive regulation of interleukin-1 beta secretion|defense response to Gram-positive bacterium|positive regulation of NF-kappaB transcription factor activity|defense response to virus|cellular response to lipopolysaccharide|cellular response to peptidoglycan|NLRP3 inflammasome complex|positive regulation of T-helper 17 cell differentiation|positive regulation of T-helper 2 cell cytokine production LOC112267934 0.999152841887003 1.02816907859967 0.97013660517434 0.943557460895085 -0.0838177169406569 1 1 0.00478697 0.00454574 0.00917795 0 GeneID:112267934,Genbank:XM_024446283.1 uncharacterized LOC112267934 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development LOC112267951 0.996216306175209 0.538097676642304 1.45433493570811 2.70273409241064 1.43441957978558 0.835201184388344 1 0.0152082 0 0.0282581 0 GeneID:112267951,Genbank:XM_024446288.1 collagen alpha-1(III) chain-like LOC112267983 25.5006284886067 29.1827530533781 21.8185039238353 0.747650637481909 -0.419563810488571 0.539746886548397 1 0.451661 0.472168 0.555507 0.168 GeneID:112267983,Genbank:XM_024447028.1 protein enabled homolog GO:0000278,GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006974,GO:0007346,GO:0023014,GO:0030145,GO:0031098,GO:0032147,GO:0035253,GO:0035869,GO:0036064,GO:0042981,GO:0045893,GO:0051301,GO:0097014,GO:1900062,GO:2000772,GO:2001020 mitotic cell cycle|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|cellular response to DNA damage stimulus|regulation of mitotic cell cycle|signal transduction by protein phosphorylation|manganese ion binding|stress-activated protein kinase signaling cascade|activation of protein kinase activity|ciliary rootlet|ciliary transition zone|ciliary basal body|regulation of apoptotic process|positive regulation of transcription, DNA-templated|cell division|ciliary plasm|regulation of replicative cell aging|regulation of cellular senescence|regulation of response to DNA damage stimulus LOC112268041 10.8524530072721 8.61937148138481 13.0855345331594 1.51815414400228 0.602318280540997 0.530951386152227 1 0.0959241 0.16917 0.266422 0.275667 GeneID:112268041,Genbank:XM_024447726.1 translation initiation factor IF-2-like GO:0000122,GO:0000151,GO:0000278,GO:0000791,GO:0000792,GO:0001702,GO:0001739,GO:0003682,GO:0005634,GO:0005654,GO:0006351,GO:0007281,GO:0008270,GO:0009948,GO:0016574,GO:0016604,GO:0031519,GO:0035102,GO:0035518,GO:0036353,GO:0043433,GO:0061630,GO:0071339,GO:0071535 negative regulation of transcription from RNA polymerase II promoter|ubiquitin ligase complex|mitotic cell cycle|euchromatin|heterochromatin|gastrulation with mouth forming second|sex chromatin|chromatin binding|nucleus|nucleoplasm|transcription, DNA-templated|germ cell development|zinc ion binding|anterior/posterior axis specification|histone ubiquitination|nuclear body|PcG protein complex|PRC1 complex|histone H2A monoubiquitination|histone H2A-K119 monoubiquitination|negative regulation of DNA binding transcription factor activity|ubiquitin protein ligase activity|MLL1 complex|RING-like zinc finger domain binding LOC112268052 46.0761918146772 45.1433869090154 47.008996720339 1.04132631464014 0.0584222288138064 0.916686218017479 1 0.875936 1.11339 0.92309 1.14059 GeneID:112268052,Genbank:XM_024447735.1 translation initiation factor IF-2-like LOC112268068 8.96781908713876 9.69556683466942 8.24007133960811 0.849880309229911 -0.234668417683098 0.856996630234933 1 0.0412104 0.0924771 0.0582167 0.0723017 GeneID:112268068,Genbank:XM_024448279.1 uncharacterized LOC112268068 LOC112268076 1.05218221594214 2.10436443188427 0 0 -Inf 0.405312649089613 1 0.121882 0.0355618 0 0 GeneID:112268076,Genbank:XM_024448784.1 uncharacterized LOC112268076 LOC112268105 15.2939376713292 14.596280854243 15.9915944884155 1.09559377817582 0.131712978183692 0.934211245721284 1 0.137394 0.404791 0.249891 0.408466 GeneID:112268105,Genbank:XM_024449293.1 translation initiation factor IF-2-like LOC112268114 224.852690161015 228.715197886614 220.990182435415 0.96622430200275 -0.0495699556984766 0.817292239114337 1 13.3079 12.859 12.8169 12.783 GeneID:112268114,Genbank:XM_024449447.1 basic proline-rich protein-like LOC112268117 2.69939345062719 1.51824048055703 3.88054642069736 2.55594977896626 1.35385948951334 0.667603597432149 1 0.0734448 0.140821 0.424067 0 GeneID:112268117,Genbank:XM_024449449.1 keratin-associated protein 21-1-like LOC112268119 11.4431450719429 10.771762187954 12.1145279559317 1.12465609104138 0.169483906685685 0.894270370913217 1 0.0894705 0.0608207 0.0210477 0.0785621 GeneID:112268119,Genbank:XM_024449456.1 protein SPT2 homolog LOC112268124 40.6484841369905 35.7457863775636 45.5511818964173 1.27430912878191 0.349715296795422 0.453869065429658 1 0.858711 1.15711 1.05507 1.12596 GeneID:112268124,Genbank:XM_024449797.1 vegetative cell wall protein gp1-like GO:0006261,GO:0006338,GO:0006351,GO:0006355,GO:0008623,GO:0016590,GO:0046872 DNA-dependent DNA replication|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|CHRAC|ACF complex|metal ion binding LOC112268131 21.7810785538884 18.3629645907392 25.1991925170377 1.37228345632961 0.456578512708299 0.477650442420162 1 0.150915 0.170317 0.259497 0.372964 GeneID:112268131,Genbank:XM_024449800.1 uncharacterized LOC112268131 LOC112268140 7.05493053587105 10.2336645113117 3.87619656043037 0.378769164862288 -1.40060920735186 0.221869361908872 1 0.182447 0.243911 0.0567419 0.079381 GeneID:112268140,Genbank:XM_024449806.1 loricrin-like LOC112268145 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:112268145,Genbank:XM_024450114.1 uncharacterized LOC112268145 GO:0005634,GO:0005737,GO:0006351,GO:0006355 nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated LOC112268184 112.417087751125 118.229635383854 106.604540118396 0.901673592854154 -0.149322824593692 0.654367105082493 1 1.33404 1.03117 0.933723 1.20634 GeneID:112268184,Genbank:XM_024451054.1 uncharacterized LOC112268184 LOC112268186 1.21093081236113 0 2.42186162472226 Inf Inf 0.339679181581212 1 0 0 0 0.0434304 GeneID:112268186,Genbank:XM_024451055.1 basic proline-rich protein-like LOC112268198 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0.0108432 0.0227528 0 GeneID:112268198,Genbank:XM_024451065.1 uncharacterized LOC112268198 LOC112268219 41.6043859558273 38.1383084575575 45.0704634540971 1.18176356731327 0.240941427745616 0.591709998794751 1 0.606184 0.492013 0.707979 0.647899 GeneID:112268219,Genbank:XM_024451328.1 uncharacterized LOC112268219 GO:0005829,GO:0016020,GO:0042803,GO:0070062 cytosol|membrane|protein homodimerization activity|extracellular exosome LOC112268232 2.83403344942343 4.69880026572591 0.969266633120943 0.206279598686283 -2.27732695097539 0.293238694822355 1 0.211781 0.078075 0 0 GeneID:112268232,Genbank:XM_024451621.1 uncharacterized LOC112268232 LOC112268233 1.80836592050886 3.13253351048394 0.484198330533773 0.154570838241079 -2.69365993276169 0.392303825257904 1 0.0448302 0.0205844 0 0 GeneID:112268233,Genbank:XM_024451648.1 uncharacterized LOC112268233 LOC112268238 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:112268238,Genbank:XM_024451710.1 translation initiation factor IF-2-like LOC112268270 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0 0 0 GeneID:112268270,Genbank:XM_024452026.1 translation initiation factor IF-2-like LOC112268271 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0117775 0 GeneID:112268271,Genbank:XM_024452027.1 translation initiation factor IF-2-like GO:0004364,GO:0005634,GO:0005737,GO:0005829,GO:0006749,GO:0008065,GO:0018916,GO:0019899,GO:0035686,GO:0042178,GO:0042802,GO:0042803,GO:0043295,GO:0043627,GO:0045171,GO:0070062,GO:0070458,GO:1901687 glutathione transferase activity|nucleus|cytoplasm|cytosol|glutathione metabolic process|establishment of blood-nerve barrier|nitrobenzene metabolic process|enzyme binding|sperm fibrous sheath|xenobiotic catabolic process|identical protein binding|protein homodimerization activity|glutathione binding|response to estrogen|intercellular bridge|extracellular exosome|cellular detoxification of nitrogen compound|glutathione derivative biosynthetic process LOC112268284 234.194182529302 240.169136575265 228.219228483339 0.950243781268783 -0.0736304162755698 0.808279188113201 1 11.1627 10.466 8.60733 12.3988 GeneID:112268284,Genbank:XM_024452143.1 basic proline-rich protein-like LOC112268321 12.9576874112098 12.8281003451534 13.0872744772662 1.02020362525546 0.0288571324195144 1 1 0.17002 0.147803 0.18333 0.122852 GeneID:112268321,Genbank:XM_024453267.1 uncharacterized LOC112268321 LOC112268409 1.47954466465558 0.538097676642304 2.42099165266886 4.49916763769675 2.16965812232218 0.604056578462201 1 0 0 0 0 GeneID:112268409,Genbank:XM_024453264.1 serine/arginine-rich splicing factor RSZ22-like LOC112268444 12.5471600703351 13.4622505711655 11.6320695695047 0.864050888669324 -0.210811811817056 0.854818898785867 1 0.0423559 0.0196321 0.0807137 0.0282171 GeneID:112268444,Genbank:XM_024453854.1 translation initiation factor IF-2-like GO:0000184,GO:0000462,GO:0003723,GO:0003735,GO:0005654,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0016020,GO:0019083,GO:0022627,GO:0031012,GO:0042274,GO:0070062,GO:0097421,GO:1990830 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|nucleoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|membrane|viral transcription|cytosolic small ribosomal subunit|extracellular matrix|ribosomal small subunit biogenesis|extracellular exosome|liver regeneration|cellular response to leukemia inhibitory factor LOC112268452 2.71873010815108 1.07619535328461 4.36126486301754 4.05248438371966 2.01880662631688 0.346334528771183 1 0.0648757 0 0.122363 0.0856541 GeneID:112268452,Genbank:XM_024453860.1 uncharacterized LOC112268452 LOC112268453 7.22942601499892 6.21704074628294 8.24181128371491 1.32568075714198 0.406733395707226 0.752737648302203 1 0.191765 0.257313 0.312391 0.167474 GeneID:112268453,Genbank:XM_024453862.1 uncharacterized LOC112268453 LOC112268459 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0.0418529 0 0 GeneID:112268459,Genbank:XM_024454295.1 uncharacterized LOC112268459 LOC150051 11.2224716287119 14.2022620016556 8.2426812557683 0.580378059129416 -0.784935114737543 0.365813102710869 1 0.687416 1.19655 0.797029 0.148115 GeneID:150051,Genbank:NM_001321023.1 uncharacterized LOC150051 LOC285500 2.96333082310306 1.56626675524197 4.36039489096415 2.78394141762302 1.47712885292731 0.47099251530264 1 0.0129416 0.00621042 0 0.0232262 GeneID:285500,Genbank:XM_017008907.2 uncharacterized LOC285500 GO:0000278,GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006974,GO:0007346,GO:0023014,GO:0030145,GO:0031098,GO:0032147,GO:0035253,GO:0035869,GO:0036064,GO:0042981,GO:0045893,GO:0051301,GO:0097014,GO:1900062,GO:2000772,GO:2001020 mitotic cell cycle|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|cellular response to DNA damage stimulus|regulation of mitotic cell cycle|signal transduction by protein phosphorylation|manganese ion binding|stress-activated protein kinase signaling cascade|activation of protein kinase activity|ciliary rootlet|ciliary transition zone|ciliary basal body|regulation of apoptotic process|positive regulation of transcription, DNA-templated|cell division|ciliary plasm|regulation of replicative cell aging|regulation of cellular senescence|regulation of response to DNA damage stimulus LOC339862 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.018231 0 GeneID:339862,Genbank:NM_001257177.1 uncharacterized LOC339862 LOC388282 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:388282,Genbank:XM_011523082.2 uncharacterized LOC388282 LOC389199 4.87578438834408 1.02816907859967 8.72339969808849 8.48440191371003 3.08481296424215 0.0521333394034577 0.834967563885779 0 0 0.204475 0.143983 GeneID:389199,Genbank:NM_203423.2 uncharacterized LOC389199 LOC389602 40.84322496428 45.8157547546046 35.8706951739555 0.782933629841607 -0.35303808105784 0.603644727758293 1 0.563618 0.276842 0.483379 0.157047 GeneID:389602,Genbank:XM_017012200.1 uncharacterized LOC389602 GO:0003964,GO:0006310,GO:0009036,GO:0032197,GO:0032199,GO:0046872,GO:0090305 RNA-directed DNA polymerase activity|DNA recombination|Type II site-specific deoxyribonuclease activity|transposition, RNA-mediated|reverse transcription involved in RNA-mediated transposition|metal ion binding|nucleic acid phosphodiester bond hydrolysis LOC389895 111.835465862041 91.8628492283808 131.808082495701 1.43483555760405 0.520885403226162 0.0713323316875522 0.926484731519311 3.35044 4.04372 4.98095 5.66827 GeneID:389895,Genbank:NM_001271560.1 chromosome 16 open reading frame 72-like LOC390877 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0291081 0 0 GeneID:390877,Genbank:XM_017026805.2 adenylate kinase isoenzyme 1-like GO:0004017,GO:0004550,GO:0005524,GO:0005815,GO:0005829,GO:0006165,GO:0009142,GO:0019206,GO:0046034 adenylate kinase activity|nucleoside diphosphate kinase activity|ATP binding|microtubule organizing center|cytosol|nucleoside diphosphate phosphorylation|nucleoside triphosphate biosynthetic process|nucleoside kinase activity|ATP metabolic process hsa00230,hsa00730 Purine metabolism|Thiamine metabolism LOC390937 0.969266633120943 0 1.93853326624189 Inf Inf 0.451830900262006 1 0 0 0 0.0367744 GeneID:390937,Genbank:XM_017027573.1 Ets2 repressor factor-like GO:0000122,GO:0000981,GO:0001701,GO:0003714,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006357,GO:0010668,GO:0043565,GO:0060707,GO:0060710 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|in utero embryonic development|transcription corepressor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|ectodermal cell differentiation|sequence-specific DNA binding|trophoblast giant cell differentiation|chorio-allantoic fusion LOC400499 3.5544578738005 3.71865746181119 3.39025828578981 0.911688780320887 -0.133386673693425 1 1 0.00330002 0.00287889 0.00306608 0.0143358 GeneID:400499,Genbank:XM_017023936.1 vitellogenin LOC400927-CSNK1E 24.4812465162887 25.2141555630343 23.7483374695432 0.941865271282767 -0.0864073899893428 0.923889483287503 1 0.70656 2.01584 0.745292 0.58478 GeneID:102800317,Genbank:NM_001289912.1 LOC400927-CSNK1E readthrough GO:0000086,GO:0003723,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006364,GO:0006468,GO:0006897,GO:0007165,GO:0008360,GO:0010389,GO:0016055,GO:0018105,GO:0032091,GO:0032436,GO:0032922,GO:0042752,GO:0097711,GO:1903827,GO:1905426,GO:2000052 G2/M transition of mitotic cell cycle|RNA binding|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|rRNA processing|protein phosphorylation|endocytosis|signal transduction|regulation of cell shape|regulation of G2/M transition of mitotic cell cycle|Wnt signaling pathway|peptidyl-serine phosphorylation|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|circadian regulation of gene expression|regulation of circadian rhythm|ciliary basal body-plasma membrane docking|regulation of cellular protein localization|positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation|positive regulation of non-canonical Wnt signaling pathway hsa04068,hsa04310,hsa04340,hsa04390,hsa04392,hsa04710 FoxO signaling pathway|Wnt signaling pathway|Hedgehog signaling pathway|Hippo signaling pathway|Hippo signaling pathway - multiple species|Circadian rhythm LOC402096 1.48041463670898 0.538097676642304 2.42273159677566 4.50240114748934 2.17069460137475 0.551001217457309 1 0 0 0 0 GeneID:402096,Genbank:XM_017005471.1 anaphase-promoting complex subunit 1-like GO:0005654,GO:0005680,GO:0005829,GO:0031145,GO:0042787,GO:0043161,GO:0051301,GO:0051436,GO:0051437,GO:0051439,GO:0070979 nucleoplasm|anaphase-promoting complex|cytosol|anaphase-promoting complex-dependent catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination LOC403312 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.011663 0 GeneID:403312,Genbank:NM_001301851.1 putative uncharacterized protein MGC39545 LOC440292 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.00955085 0 GeneID:440292,Genbank:XM_011522301.2 COMM domain-containing protein 4-like GO:0005634,GO:0005737,GO:0006351,GO:0006355 nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated LOC441155 11.8868346830418 16.988802934237 6.7848664318466 0.399372837398289 -1.32419188099226 0.121121191608403 1 0.146606 0.131404 0.0579629 0.046211 GeneID:441155,Genbank:NM_001271675.1 zinc finger CCCH-type domain-containing-like GO:0003723,GO:0005654,GO:0006369,GO:0006405,GO:0006406,GO:0016973,GO:0031124,GO:0046872 RNA binding|nucleoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|metal ion binding LOC644215 29.5004805105644 30.8930986326749 28.1078623884539 0.909842768530991 -0.136310842608479 0.832597549348414 1 0 0 0.188217 0 GeneID:644215,Genbank:XM_011540442.2 uncharacterized LOC644215 LOC644249 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0 0.0384091 GeneID:644249,Genbank:XM_017015390.1 ankyrin repeat domain-containing protein 18B-like LOC646588 5.1741889891243 7.92738632557974 2.42099165266886 0.30539594681502 -1.71124717993228 0.383024341547509 1 0.067747 0.00811742 0 0.0378414 GeneID:646588,Genbank:XM_017012918.2 uncharacterized LOC646588 LOC653513 315.440592606144 295.507970376016 335.373214836273 1.13490412596835 0.182570427179457 0.369808655552091 1 0.43851 0.591408 0.708034 0.58674 GeneID:653513,Genbank:XM_017003023.2 phosphodiesterase 4D interacting protein-like GO:0005634,GO:0005737,GO:0005794,GO:0005813,GO:0019899,GO:0030016,GO:0032947,GO:0043623,GO:1903358 nucleus|cytoplasm|Golgi apparatus|centrosome|enzyme binding|myofibril|protein complex scaffold activity|cellular protein complex assembly|regulation of Golgi organization LOC728026 2.18650550293236 0.980142803914724 3.39286820195 3.46160599088089 1.79144152269665 0.511830679145683 1 0 0.108148 0.163175 0.101374 GeneID:728026,Genbank:XM_017015408.1 prothymosin alpha-like GO:0005634,GO:0008283,GO:0030154,GO:0033613,GO:0042393,GO:0043066,GO:0043154,GO:0043486,GO:0045944,GO:0051092,GO:0070062 nucleus|cell proliferation|cell differentiation|activating transcription factor binding|histone binding|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|histone exchange|positive regulation of transcription from RNA polymerase II promoter|positive regulation of NF-kappaB transcription factor activity|extracellular exosome LOC728392 137.638137039486 142.483265453189 132.793008625783 0.931990210944527 -0.101613293115053 0.705065075860915 1 5.34663 5.3521 5.56292 4.89826 GeneID:728392,Genbank:NM_001162371.2 uncharacterized LOC728392 LOC728485 11.2127920495232 12.7320477957835 9.69353630326283 0.761349349196841 -0.393369500943571 0.674024455524137 1 0.265455 0.333308 0.247168 0.184822 GeneID:728485,Genbank:NM_001294306.1 uncharacterized LOC728485 LOC730098 146.582969994974 135.19983800873 157.966101981219 1.16838972818162 0.224521579980707 0.492782829210906 1 1.59558 2.19833 2.19945 2.29842 GeneID:730098,Genbank:NM_001320037.1 uncharacterized LOC730098 LOC730183 15.1429963225372 13.3181717471107 16.9678208979636 1.27403529704778 0.349405247900634 0.668126210427581 1 0.71259 0.722132 1.30438 0.729889 GeneID:730183,Genbank:NM_001256932.1 uncharacterized LOC730183 LOC730268 101.284932750811 98.3680476227734 104.201817878848 1.05930554074273 0.0831187730288733 0.799154359104442 1 0.844542 1.14908 1.16636 0.888728 GeneID:730268,Genbank:XM_024453270.1 anaphase-promoting complex subunit 1-like GO:0005654,GO:0005680,GO:0005829,GO:0031145,GO:0042787,GO:0043161,GO:0051301,GO:0051436,GO:0051437,GO:0051439,GO:0070979 nucleoplasm|anaphase-promoting complex|cytosol|anaphase-promoting complex-dependent catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|cell division|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination LONP1 4358.02219243368 4038.27003254714 4677.77435232023 1.15836096016831 0.212084885709972 0.166533845161363 1 39.3327 39.5928 43.6864 48.8976 GeneID:9361,Genbank:NM_001276480.1,HGNC:HGNC:9479,MIM:605490 lon peptidase 1, mitochondrial GO:0000002,GO:0001018,GO:0001666,GO:0003697,GO:0003727,GO:0004176,GO:0004252,GO:0005524,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006515,GO:0007005,GO:0007568,GO:0009725,GO:0010044,GO:0016020,GO:0032042,GO:0034599,GO:0042645,GO:0043531,GO:0043565,GO:0043623,GO:0051260,GO:0051603,GO:0051880,GO:0070182,GO:0070407 mitochondrial genome maintenance|mitochondrial promoter sequence-specific DNA binding|response to hypoxia|single-stranded DNA binding|single-stranded RNA binding|ATP-dependent peptidase activity|serine-type endopeptidase activity|ATP binding|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|protein quality control for misfolded or incompletely synthesized proteins|mitochondrion organization|aging|response to hormone|response to aluminum ion|membrane|mitochondrial DNA metabolic process|cellular response to oxidative stress|mitochondrial nucleoid|ADP binding|sequence-specific DNA binding|cellular protein complex assembly|protein homooligomerization|proteolysis involved in cellular protein catabolic process|G-quadruplex DNA binding|DNA polymerase binding|oxidation-dependent protein catabolic process LONP2 2035.77037065587 1937.13818766667 2134.40255364507 1.10183288277229 0.139905424019112 0.310939484146809 1 9.98349 9.7086 11.6906 10.0599 GeneID:83752,Genbank:NM_001348078.1,HGNC:HGNC:20598,MIM:617774 lon peptidase 2, peroxisomal GO:0002020,GO:0004176,GO:0004252,GO:0005102,GO:0005524,GO:0005634,GO:0005777,GO:0005782,GO:0006515,GO:0006625,GO:0007031,GO:0008233,GO:0014070,GO:0016020,GO:0016485,GO:0019899,GO:0031998 protease binding|ATP-dependent peptidase activity|serine-type endopeptidase activity|receptor binding|ATP binding|nucleus|peroxisome|peroxisomal matrix|protein quality control for misfolded or incompletely synthesized proteins|protein targeting to peroxisome|peroxisome organization|peptidase activity|response to organic cyclic compound|membrane|protein processing|enzyme binding|regulation of fatty acid beta-oxidation LONRF1 327.161545109997 311.669500984646 342.653589235348 1.09941328282946 0.136733814865267 0.467079278845293 1 3.66519 3.30273 4.30282 3.48081 GeneID:91694,Genbank:NM_001329976.1,HGNC:HGNC:26302 LON peptidase N-terminal domain and ring finger 1 GO:0000209,GO:0004842,GO:0005622,GO:0005829,GO:0031624,GO:0032436,GO:0046872,GO:0061630 protein polyubiquitination|ubiquitin-protein transferase activity|intracellular|cytosol|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity LONRF2 656.824911633842 609.886560053234 703.76326321445 1.15392485965426 0.20654928279311 0.317082182190723 1 2.06391 1.79489 2.60039 1.89161 GeneID:164832,Genbank:NM_198461.3,HGNC:HGNC:24788 LON peptidase N-terminal domain and ring finger 2 GO:0000209,GO:0005622,GO:0031624,GO:0032436,GO:0046872,GO:0061630 protein polyubiquitination|intracellular|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity LONRF3 423.648386181148 461.023574720346 386.273197641951 0.837859968172477 -0.255218948939227 0.162338072625165 1 1.91027 1.92725 1.90601 1.45729 GeneID:79836,Genbank:XM_005262476.2,HGNC:HGNC:21152 LON peptidase N-terminal domain and ring finger 3 GO:0000209,GO:0005622,GO:0031624,GO:0032436,GO:0046872,GO:0061630 protein polyubiquitination|intracellular|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity LOX 295.807831129766 258.194900242355 333.420762017177 1.2913530116366 0.368883437918689 0.0595238552011478 0.879410748501007 2.2933 1.74746 2.60832 2.48299 GeneID:4015,Genbank:NM_002317.6,HGNC:HGNC:6664,MIM:153455 lysyl oxidase LOXL1 1075.6032303873 1017.12100142042 1134.08545935417 1.11499561779809 0.157038040016981 0.316027738687658 1 14.6424 15.5226 18.7016 16.1355 GeneID:4016,Genbank:NM_005576.3,HGNC:HGNC:6665,MIM:153456 lysyl oxidase like 1 GO:0001669,GO:0005507,GO:0005576,GO:0005604,GO:0005615,GO:0016641,GO:0018277,GO:0030198,GO:0031012,GO:0032496,GO:0035904,GO:0055114 acrosomal vesicle|copper ion binding|extracellular region|basement membrane|extracellular space|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|protein deamination|extracellular matrix organization|extracellular matrix|response to lipopolysaccharide|aorta development|oxidation-reduction process LOXL2 19612.5414330708 20096.0416257403 19129.0412404013 0.951881051833591 -0.0711467909459436 0.554141613437477 1 166.291 184.432 177.559 164.157 GeneID:4017,Genbank:NM_002318.2,HGNC:HGNC:6666,MIM:606663 lysyl oxidase like 2 LOXL3 110.240960693395 99.3383817715802 121.14353961521 1.21950385595941 0.286294319810789 0.312356188733894 1 0.610583 0.557037 0.685922 0.823951 GeneID:84695,Genbank:NM_001289164.2,HGNC:HGNC:13869,MIM:607163 lysyl oxidase like 3 LOXL4 417.86597392247 472.795097022431 362.936850822509 0.767640893715297 -0.381496526151375 0.0709493023879092 0.924091273490813 3.402 3.39995 2.30835 3.08287 GeneID:84171,Genbank:NM_032211.6,HGNC:HGNC:17171,MIM:607318 lysyl oxidase like 4 LPAR1 11.857043934556 10.6276833638992 13.0864045052128 1.23135062055627 0.300241620078672 0.780082931840182 1 0.0491011 0.106778 0.124768 0.0872069 GeneID:1902,Genbank:NM_001351397.1,HGNC:HGNC:3166,MIM:602282 lysophosphatidic acid receptor 1 hsa04015,hsa04072,hsa04080,hsa04151,hsa04540,hsa04810,hsa05200 Rap1 signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Gap junction|Regulation of actin cytoskeleton|Pathways in cancer LPAR2 40.0612848667281 38.4362747607751 41.6862949726811 1.08455606668789 0.117104635805747 0.823412816579052 1 0.758607 0.749398 1.0507 0.756975 GeneID:9170,Genbank:NM_004720.5,HGNC:HGNC:3168,MIM:605110 lysophosphatidic acid receptor 2 hsa04015,hsa04072,hsa04080,hsa04151,hsa04810,hsa05200 Rap1 signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer LPAR3 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0.010115 0 0 0.0180331 GeneID:23566,Genbank:XM_024446127.1,HGNC:HGNC:14298,MIM:605106 lysophosphatidic acid receptor 3 GO:0000187,GO:0001965,GO:0004930,GO:0005543,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007204,GO:0007268,GO:0008289,GO:0030424,GO:0032060,GO:0048672,GO:0051482,GO:0051928,GO:0070915 activation of MAPK activity|G-protein alpha-subunit binding|G-protein coupled receptor activity|phospholipid binding|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|lipid binding|axon|bleb assembly|positive regulation of collateral sprouting|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|positive regulation of calcium ion transport|lysophosphatidic acid receptor activity hsa04015,hsa04072,hsa04080,hsa04151,hsa05200 Rap1 signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Pathways in cancer LPAR4 22.1130434837448 21.9277345733876 22.2983523941021 1.01690178342291 0.0241803444743719 0.97984739375908 1 0.215886 0.11145 0.225879 0.123168 GeneID:2846,Genbank:XM_005262126.3,HGNC:HGNC:4478,MIM:300086 lysophosphatidic acid receptor 4 GO:0005886,GO:0005887,GO:0007186,GO:0016604,GO:0035025,GO:0035727,GO:0043231,GO:0051482,GO:0070915 plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|nuclear body|positive regulation of Rho protein signal transduction|lysophosphatidic acid binding|intracellular membrane-bounded organelle|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|lysophosphatidic acid receptor activity hsa04015,hsa04072,hsa04080,hsa04151,hsa04810,hsa05200 Rap1 signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer LPAR5 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0217392 0 0 0 GeneID:57121,Genbank:NM_020400.5,HGNC:HGNC:13307,MIM:606926 lysophosphatidic acid receptor 5 GO:0004930,GO:0005886,GO:0007186,GO:0016021 G-protein coupled receptor activity|plasma membrane|G-protein coupled receptor signaling pathway|integral component of membrane hsa04015,hsa04072,hsa04151,hsa04810,hsa05200 Rap1 signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Regulation of actin cytoskeleton|Pathways in cancer LPAR6 55.8682332785484 59.8837465873133 51.8527199697835 0.865889710059805 -0.207744816913094 0.597658406352381 1 0.530209 0.60729 0.480557 0.511296 GeneID:10161,Genbank:XM_024449304.1,HGNC:HGNC:15520,MIM:609239 lysophosphatidic acid receptor 6 GO:0005886,GO:0005887,GO:0007186,GO:0035025,GO:0043231,GO:0051482,GO:0070915 plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|positive regulation of Rho protein signal transduction|intracellular membrane-bounded organelle|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|lysophosphatidic acid receptor activity hsa04072,hsa04080,hsa04151,hsa05200 Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Pathways in cancer LPCAT1 2598.97844223086 2284.43882217015 2913.51806229157 1.27537583148049 0.350922447331367 0.0104422419006687 0.411562670934461 20.0923 18.8713 25.6155 25.2947 GeneID:79888,Genbank:NM_024830.4,HGNC:HGNC:25718,MIM:610472 lysophosphatidylcholine acyltransferase 1 GO:0000139,GO:0003841,GO:0005509,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0005886,GO:0006654,GO:0006656,GO:0008654,GO:0016020,GO:0016021,GO:0035577,GO:0036148,GO:0036151,GO:0043129,GO:0043312,GO:0045732,GO:0047144,GO:0047159,GO:0047184,GO:0047191,GO:0047192,GO:0060041,GO:2001246 Golgi membrane|1-acylglycerol-3-phosphate O-acyltransferase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|plasma membrane|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phospholipid biosynthetic process|membrane|integral component of membrane|azurophil granule membrane|phosphatidylglycerol acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|surfactant homeostasis|neutrophil degranulation|positive regulation of protein catabolic process|2-acylglycerol-3-phosphate O-acyltransferase activity|1-alkenylglycerophosphocholine O-acyltransferase activity|1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|retina development in camera-type eye|negative regulation of phosphatidylcholine biosynthetic process hsa00564,hsa00565 Glycerophospholipid metabolism|Ether lipid metabolism LPCAT2 526.670816559605 573.554649724343 479.786983394867 0.836514852813865 -0.257536938496214 0.143852996873231 1 4.25603 3.71296 3.43758 3.23467 GeneID:54947,Genbank:NM_017839.4,HGNC:HGNC:26032,MIM:612040 lysophosphatidylcholine acyltransferase 2 GO:0000139,GO:0003841,GO:0005509,GO:0005783,GO:0005789,GO:0005795,GO:0005811,GO:0006663,GO:0016021,GO:0036151,GO:0047144,GO:0047184,GO:0047192,GO:0061024 Golgi membrane|1-acylglycerol-3-phosphate O-acyltransferase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi stack|lipid droplet|platelet activating factor biosynthetic process|integral component of membrane|phosphatidylcholine acyl-chain remodeling|2-acylglycerol-3-phosphate O-acyltransferase activity|1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|membrane organization hsa00564,hsa00565 Glycerophospholipid metabolism|Ether lipid metabolism LPCAT3 637.598276565139 668.94506831665 606.251484813628 0.906279922713556 -0.141971370513492 0.385068452455962 1 10.0098 10.4092 8.99028 9.42633 GeneID:10162,Genbank:NM_005768.5,HGNC:HGNC:30244,MIM:611950 lysophosphatidylcholine acyltransferase 3 GO:0003841,GO:0005789,GO:0008654,GO:0016020,GO:0016021,GO:0036150,GO:0036151,GO:0036152,GO:0047144,GO:0047184,GO:0097006 1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum membrane|phospholipid biosynthetic process|membrane|integral component of membrane|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|2-acylglycerol-3-phosphate O-acyltransferase activity|1-acylglycerophosphocholine O-acyltransferase activity|regulation of plasma lipoprotein particle levels hsa00564,hsa04216 Glycerophospholipid metabolism|Ferroptosis LPCAT4 823.401943438859 871.437558871846 775.366328005871 0.889755462238341 -0.168519210372333 0.273046336112582 1 13.4036 14.9882 11.7096 12.6308 GeneID:254531,Genbank:NM_153613.2,HGNC:HGNC:30059,MIM:612039 lysophosphatidylcholine acyltransferase 4 GO:0003841,GO:0005783,GO:0005789,GO:0006644,GO:0006654,GO:0016020,GO:0016021,GO:0036148,GO:0036150,GO:0036151,GO:0036152,GO:0047144,GO:0047166,GO:0047184,GO:0047192,GO:0071617 1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|phospholipid metabolic process|phosphatidic acid biosynthetic process|membrane|integral component of membrane|phosphatidylglycerol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|2-acylglycerol-3-phosphate O-acyltransferase activity|1-alkenylglycerophosphoethanolamine O-acyltransferase activity|1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|lysophospholipid acyltransferase activity hsa00564,hsa00565 Glycerophospholipid metabolism|Ether lipid metabolism LPGAT1 724.318563300345 758.481005048228 690.156121552461 0.909918794220268 -0.136190297271982 0.415983891224235 1 3.42143 3.07902 3.3049 2.63862 GeneID:9926,Genbank:NM_014873.2,HGNC:HGNC:28985,MIM:610473 lysophosphatidylglycerol acyltransferase 1 GO:0003841,GO:0005737,GO:0005789,GO:0008654,GO:0016020,GO:0016021,GO:0036148,GO:0045723,GO:0047144 1-acylglycerol-3-phosphate O-acyltransferase activity|cytoplasm|endoplasmic reticulum membrane|phospholipid biosynthetic process|membrane|integral component of membrane|phosphatidylglycerol acyl-chain remodeling|positive regulation of fatty acid biosynthetic process|2-acylglycerol-3-phosphate O-acyltransferase activity hsa00564 Glycerophospholipid metabolism LPIN1 897.718646643377 868.216747465391 927.220545821364 1.06795975604966 0.0948572829416581 0.660117359196943 1 3.8974 3.53737 4.61174 3.27759 GeneID:23175,Genbank:NM_001261428.2,HGNC:HGNC:13345,MIM:605518 lipin 1 GO:0003713,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005741,GO:0005789,GO:0005829,GO:0006351,GO:0006642,GO:0006646,GO:0006656,GO:0007077,GO:0008195,GO:0009062,GO:0019432,GO:0031100,GO:0031965,GO:0032869,GO:0045944 transcription coactivator activity|nucleus|nuclear envelope|nucleoplasm|cytoplasm|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|transcription, DNA-templated|triglyceride mobilization|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|mitotic nuclear envelope disassembly|phosphatidate phosphatase activity|fatty acid catabolic process|triglyceride biosynthetic process|animal organ regeneration|nuclear membrane|cellular response to insulin stimulus|positive regulation of transcription from RNA polymerase II promoter hsa00561,hsa00564,hsa04150 Glycerolipid metabolism|Glycerophospholipid metabolism|mTOR signaling pathway LPIN2 1829.67147423022 1673.13988284084 1986.2030656196 1.18711118298561 0.247455061879725 0.113629455868111 1 9.04082 9.06245 12.3951 9.50157 GeneID:9663,Genbank:XM_017026098.1,HGNC:HGNC:14450,MIM:605519 lipin 2 hsa00561,hsa00564 Glycerolipid metabolism|Glycerophospholipid metabolism LPIN3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:64900,Genbank:XM_011528997.3,HGNC:HGNC:14451,MIM:605520 lipin 3 GO:0003713,GO:0005634,GO:0005789,GO:0006646,GO:0006656,GO:0008195,GO:0009062,GO:0019432,GO:0045944 transcription coactivator activity|nucleus|endoplasmic reticulum membrane|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidate phosphatase activity|fatty acid catabolic process|triglyceride biosynthetic process|positive regulation of transcription from RNA polymerase II promoter hsa00561,hsa00564 Glycerolipid metabolism|Glycerophospholipid metabolism LPL 238.28986759871 241.513872266444 235.065862930977 0.973301701989385 -0.0390410170178284 0.886352556695894 1 2.61713 2.32566 2.70446 2.10725 GeneID:4023,Genbank:NM_000237.2,HGNC:HGNC:6677,MIM:609708 lipoprotein lipase hsa00561,hsa03320,hsa04979,hsa05010 Glycerolipid metabolism|PPAR signaling pathway|Cholesterol metabolism|Alzheimer disease LPP 603.134756567676 461.128418923969 745.141094211384 1.61590798491698 0.692345048656855 0.332308713795497 1 0.867797 0.710842 1.83908 0.764761 GeneID:4026,Genbank:XM_024453519.1,HGNC:HGNC:6679,MIM:600700 LIM domain containing preferred translocation partner in lipoma LPXN 116.887712896152 115.520546691281 118.254879101022 1.02366966299985 0.033750234440593 0.954085396721267 1 0.503939 0.835039 0.751365 0.700139 GeneID:9404,Genbank:NM_001143995.2,HGNC:HGNC:14061,MIM:605390 leupaxin GO:0002102,GO:0003712,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006351,GO:0006355,GO:0006461,GO:0007155,GO:0007162,GO:0007165,GO:0016020,GO:0016607,GO:0033628,GO:0042995,GO:0046872,GO:0048471,GO:0050859 podosome|transcription cofactor activity|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|transcription, DNA-templated|regulation of transcription, DNA-templated|protein complex assembly|cell adhesion|negative regulation of cell adhesion|signal transduction|membrane|nuclear speck|regulation of cell adhesion mediated by integrin|cell projection|metal ion binding|perinuclear region of cytoplasm|negative regulation of B cell receptor signaling pathway LRAT 24.970012960166 26.194298366949 23.745727553383 0.906522756240132 -0.141584858809029 0.838714995964178 1 0.191703 0.229217 0.202963 0.18036 GeneID:9227,Genbank:NM_001301645.1,HGNC:HGNC:6685,MIM:604863 lecithin retinol acyltransferase GO:0001523,GO:0001972,GO:0005771,GO:0005789,GO:0005791,GO:0006776,GO:0007601,GO:0016021,GO:0016416,GO:0016746,GO:0019841,GO:0032370,GO:0042572,GO:0042573,GO:0047173,GO:0048471,GO:0102279,GO:1990830 retinoid metabolic process|retinoic acid binding|multivesicular body|endoplasmic reticulum membrane|rough endoplasmic reticulum|vitamin A metabolic process|visual perception|integral component of membrane|O-palmitoyltransferase activity|transferase activity, transferring acyl groups|retinol binding|positive regulation of lipid transport|retinol metabolic process|retinoic acid metabolic process|phosphatidylcholine-retinol O-acyltransferase activity|perinuclear region of cytoplasm|lecithin:11-cis retinol acyltransferase activity|cellular response to leukemia inhibitory factor hsa00830,hsa04977 Retinol metabolism|Vitamin digestion and absorption LRBA 516.345353206605 513.536632968083 519.154073445127 1.01093873370742 0.0156955677110109 0.959280475786218 1 1.57704 1.42159 1.82452 1.1245 GeneID:987,Genbank:XM_017008872.2,HGNC:HGNC:1742,MIM:606453 LPS responsive beige-like anchor protein GO:0005764,GO:0005783,GO:0005794,GO:0005886,GO:0016020,GO:0016021 lysosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|membrane|integral component of membrane LRCH1 405.476004032966 432.418153964042 378.533854101891 0.875388442024957 -0.19200475905223 0.287847582836686 1 1.671 2.14266 1.90861 1.4078 GeneID:23143,Genbank:NM_001164213.1,HGNC:HGNC:20309,MIM:610368 leucine rich repeats and calponin homology domain containing 1 GO:0005737,GO:0005886,GO:0007165,GO:0034260,GO:1990869,GO:2000405 cytoplasm|plasma membrane|signal transduction|negative regulation of GTPase activity|cellular response to chemokine|negative regulation of T cell migration LRCH2 119.754250884983 138.197084349412 101.311417420554 0.733093739983703 -0.447930408720822 0.339415091897505 1 0.902361 0.666271 0.782062 0.452864 GeneID:57631,Genbank:XM_006724724.3,HGNC:HGNC:29292 leucine rich repeats and calponin homology domain containing 2 GO:0005886,GO:0007165 plasma membrane|signal transduction LRCH3 1274.2545201236 1287.43138254105 1261.07765770614 0.9795299965557 -0.0298384214659472 0.853846687262598 1 3.89017 3.72464 4.30357 3.54156 GeneID:84859,Genbank:NM_032773.3,HGNC:HGNC:28637 leucine rich repeats and calponin homology domain containing 3 GO:0005576,GO:0005829,GO:0005886,GO:0007165 extracellular region|cytosol|plasma membrane|signal transduction LRCH4 774.132033199431 775.731590667815 772.532475731047 0.995876002762741 -0.00596197240895501 0.941367199898977 1 10.7155 11.8972 11.7019 10.8465 GeneID:4034,Genbank:NM_001289934.1,HGNC:HGNC:6691 leucine rich repeats and calponin homology domain containing 4 GO:0005737,GO:0007165,GO:0007399,GO:0016323,GO:0016605,GO:0045199 cytoplasm|signal transduction|nervous system development|basolateral plasma membrane|PML body|maintenance of epithelial cell apical/basal polarity LRFN1 66.117921458751 63.9003703523421 68.33547256516 1.0694065181213 0.096810375221736 0.816673348251323 1 1.0213 1.09313 1.16099 1.15464 GeneID:57622,Genbank:XM_005259102.4,HGNC:HGNC:29290,MIM:612807 leucine rich repeat and fibronectin type III domain containing 1 GO:0005578,GO:0005615,GO:0005886,GO:0007409,GO:0009986,GO:0014069,GO:0016021,GO:0030054,GO:0045211 proteinaceous extracellular matrix|extracellular space|plasma membrane|axonogenesis|cell surface|postsynaptic density|integral component of membrane|cell junction|postsynaptic membrane LRFN3 442.365577239191 442.266591277019 442.464563201363 1.00044763029415 0.00064564951015397 0.99532414317686 1 9.97871 8.55775 9.39111 8.9212 GeneID:79414,Genbank:NM_024509.1,HGNC:HGNC:28370,MIM:612809 leucine rich repeat and fibronectin type III domain containing 3 GO:0005578,GO:0005615,GO:0005886,GO:0007155,GO:0007409,GO:0009986,GO:0016021,GO:0030054,GO:0030424,GO:0030425,GO:0042734,GO:0045211 proteinaceous extracellular matrix|extracellular space|plasma membrane|cell adhesion|axonogenesis|cell surface|integral component of membrane|cell junction|axon|dendrite|presynaptic membrane|postsynaptic membrane LRFN4 863.715699294548 825.525751567872 901.905647021224 1.09252272907088 0.127663294166835 0.43824353478633 1 17.7802 18.8431 21.4873 19.7332 GeneID:78999,Genbank:XM_005274239.3,HGNC:HGNC:28456,MIM:612810 leucine rich repeat and fibronectin type III domain containing 4 GO:0005578,GO:0005615,GO:0005886,GO:0007409,GO:0009986,GO:0016021 proteinaceous extracellular matrix|extracellular space|plasma membrane|axonogenesis|cell surface|integral component of membrane LRG1 2.51358681467884 3.57457863775636 1.45259499160132 0.406368173372474 -1.29914067977463 0.586978220468394 1 0.0609799 0.107446 0 0.0795255 GeneID:116844,Genbank:NM_052972.2,HGNC:HGNC:29480,MIM:611289 leucine rich alpha-2-glycoprotein 1 GO:0001938,GO:0005160,GO:0005576,GO:0005615,GO:0016020,GO:0030511,GO:0035580,GO:0043231,GO:0043312,GO:0045766,GO:0050873,GO:0070062,GO:1904724,GO:1904813 positive regulation of endothelial cell proliferation|transforming growth factor beta receptor binding|extracellular region|extracellular space|membrane|positive regulation of transforming growth factor beta receptor signaling pathway|specific granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|positive regulation of angiogenesis|brown fat cell differentiation|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen LRGUK 4.50221291926406 4.16070258908361 4.84372324944452 1.16415993350569 0.21928927081104 0.951868334990108 1 0.00617168 0.00588101 0.00197151 0.00920253 GeneID:136332,Genbank:XM_024446660.1,HGNC:HGNC:21964,MIM:616478 leucine rich repeats and guanylate kinase domain containing GO:0001669,GO:0002177,GO:0005524,GO:0007283,GO:0016301,GO:0030154,GO:0035082,GO:0042995 acrosomal vesicle|manchette|ATP binding|spermatogenesis|kinase activity|cell differentiation|axoneme assembly|cell projection LRIF1 111.456977430495 92.525408418862 130.388546442128 1.40921881535351 0.494895642389445 0.188254641365918 1 0.821914 0.6842 1.33779 0.844577 GeneID:55791,Genbank:XM_017001769.2,HGNC:HGNC:30299,MIM:615354 ligand dependent nuclear receptor interacting factor 1 GO:0005634,GO:0005815,GO:0006351,GO:0006355,GO:0016363,GO:0042974 nucleus|microtubule organizing center|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear matrix|retinoic acid receptor binding LRIG1 2570.86368168596 2432.63147365916 2709.09588971277 1.11364829364711 0.155293680500492 0.262467377325791 1 16.5591 16.7127 19.4699 18.1243 GeneID:26018,Genbank:XM_011533579.3,HGNC:HGNC:17360,MIM:608868 leucine rich repeats and immunoglobulin like domains 1 LRIG2 238.300450765591 246.866440068398 229.734461462785 0.930602237384448 -0.103763439213256 0.638234940388077 1 0.834632 0.860682 0.929057 0.707223 GeneID:9860,Genbank:XM_005271369.2,HGNC:HGNC:20889,MIM:608869 leucine rich repeats and immunoglobulin like domains 2 GO:0005102,GO:0005737,GO:0005886,GO:0007605,GO:0010640,GO:0016021,GO:0030426,GO:0043025,GO:0048681,GO:0051045,GO:0060384,GO:0097708,GO:2000010,GO:2001222 receptor binding|cytoplasm|plasma membrane|sensory perception of sound|regulation of platelet-derived growth factor receptor signaling pathway|integral component of membrane|growth cone|neuronal cell body|negative regulation of axon regeneration|negative regulation of membrane protein ectodomain proteolysis|innervation|intracellular vesicle|positive regulation of protein localization to cell surface|regulation of neuron migration LRIG3 477.441521968598 437.289442018292 517.593601918904 1.18364074725878 0.243231267795445 0.169995499762382 1 2.90603 3.1904 3.85665 3.36478 GeneID:121227,Genbank:NM_153377.4,HGNC:HGNC:30991,MIM:608870 leucine rich repeats and immunoglobulin like domains 3 GO:0005615,GO:0005886,GO:0016021,GO:0030659,GO:0032474 extracellular space|plasma membrane|integral component of membrane|cytoplasmic vesicle membrane|otolith morphogenesis LRIT3 2.26604956401506 2.59443583384164 1.93766329418849 0.746853427212863 -0.42110295840788 0.964656809965331 1 0.0353612 0.0222874 0.0112876 0.0315531 GeneID:345193,Genbank:XM_017008168.1,HGNC:HGNC:24783,MIM:615004 leucine rich repeat, Ig-like and transmembrane domains 3 GO:0005789,GO:0007601,GO:0016021,GO:0030425,GO:0040036,GO:0043204,GO:0050896 endoplasmic reticulum membrane|visual perception|integral component of membrane|dendrite|regulation of fibroblast growth factor receptor signaling pathway|perikaryon|response to stimulus LRMDA 123.668318644889 117.951286390852 129.385350898925 1.09693887076555 0.133483130754177 0.635918612276498 1 1.55013 1.53692 1.83009 1.47584 GeneID:83938,Genbank:NM_001305581.1,HGNC:HGNC:23405,MIM:614537 leucine rich melanocyte differentiation associated GO:0030318 melanocyte differentiation LRP1 416.153508907456 396.104843944512 436.2021738704 1.10122908249894 0.139114615866093 0.447952742565633 1 0.924729 0.883036 1.15827 0.898342 GeneID:4035,Genbank:XM_017019303.1,HGNC:HGNC:6692,MIM:107770 LDL receptor related protein 1 GO:0001523,GO:0002020,GO:0002265,GO:0003723,GO:0004872,GO:0005041,GO:0005044,GO:0005509,GO:0005634,GO:0005765,GO:0005769,GO:0005886,GO:0005887,GO:0005905,GO:0005925,GO:0006629,GO:0006898,GO:0006909,GO:0007205,GO:0007568,GO:0008283,GO:0010715,GO:0010875,GO:0010942,GO:0010977,GO:0014912,GO:0016020,GO:0016323,GO:0016964,GO:0021987,GO:0030136,GO:0030178,GO:0030226,GO:0030425,GO:0030666,GO:0031623,GO:0032050,GO:0032092,GO:0032370,GO:0032374,GO:0032403,GO:0032429,GO:0032956,GO:0034185,GO:0035909,GO:0042157,GO:0042953,GO:0042954,GO:0043025,GO:0043235,GO:0043277,GO:0043395,GO:0043524,GO:0045056,GO:0045732,GO:0045807,GO:0051222,GO:0051246,GO:0070325,GO:0097242,GO:0098797,GO:1900223,GO:1903078,GO:1904646,GO:1905167,GO:2000587 retinoid metabolic process|protease binding|astrocyte activation involved in immune response|RNA binding|receptor activity|low-density lipoprotein receptor activity|scavenger receptor activity|calcium ion binding|nucleus|lysosomal membrane|early endosome|plasma membrane|integral component of plasma membrane|clathrin-coated pit|focal adhesion|lipid metabolic process|receptor-mediated endocytosis|phagocytosis|protein kinase C-activating G-protein coupled receptor signaling pathway|aging|cell proliferation|regulation of extracellular matrix disassembly|positive regulation of cholesterol efflux|positive regulation of cell death|negative regulation of neuron projection development|negative regulation of smooth muscle cell migration|membrane|basolateral plasma membrane|alpha-2 macroglobulin receptor activity|cerebral cortex development|clathrin-coated vesicle|negative regulation of Wnt signaling pathway|apolipoprotein receptor activity|dendrite|endocytic vesicle membrane|receptor internalization|clathrin heavy chain binding|positive regulation of protein binding|positive regulation of lipid transport|regulation of cholesterol transport|protein complex binding|regulation of phospholipase A2 activity|regulation of actin cytoskeleton organization|apolipoprotein binding|aorta morphogenesis|lipoprotein metabolic process|lipoprotein transport|lipoprotein transporter activity|neuronal cell body|receptor complex|apoptotic cell clearance|heparan sulfate proteoglycan binding|negative regulation of neuron apoptotic process|transcytosis|positive regulation of protein catabolic process|positive regulation of endocytosis|positive regulation of protein transport|regulation of protein metabolic process|lipoprotein particle receptor binding|amyloid-beta clearance|plasma membrane protein complex|positive regulation of amyloid-beta clearance|positive regulation of protein localization to plasma membrane|cellular response to amyloid-beta|positive regulation of lysosomal protein catabolic process|negative regulation of platelet-derived growth factor receptor-beta signaling pathway hsa04979,hsa05010,hsa05144 Cholesterol metabolism|Alzheimer disease|Malaria LRP10 3810.81202955504 3486.71955263534 4134.90450647474 1.18590108669609 0.245983683000207 0.0711169957678601 0.925271977431395 18.0876 19.2519 23.1903 21.6982 GeneID:26020,Genbank:XM_005267510.1,HGNC:HGNC:14553,MIM:609921 LDL receptor related protein 10 GO:0005041,GO:0005905,GO:0006629,GO:0006869,GO:0016020,GO:0016021,GO:0048839 low-density lipoprotein receptor activity|clathrin-coated pit|lipid metabolic process|lipid transport|membrane|integral component of membrane|inner ear development LRP11 792.003316132821 778.949351071707 805.057281193936 1.03351685200881 0.0475619128188286 0.782693484752056 1 5.48601 5.56519 6.9166 5.1536 GeneID:84918,Genbank:NM_032832.5,HGNC:HGNC:16936 LDL receptor related protein 11 GO:0005886,GO:0009408,GO:0009409,GO:0009414,GO:0009612,GO:0016021,GO:0033555,GO:0035902,GO:0042594,GO:0051219 plasma membrane|response to heat|response to cold|response to water deprivation|response to mechanical stimulus|integral component of membrane|multicellular organismal response to stress|response to immobilization stress|response to starvation|phosphoprotein binding LRP12 1168.04563251521 1137.89501236172 1198.1962526687 1.05299367661505 0.0744967727895583 0.768647643647925 1 11.9197 11.4053 14.9478 9.79163 GeneID:29967,Genbank:NM_001135703.2,HGNC:HGNC:31708 LDL receptor related protein 12 GO:0001764,GO:0005041,GO:0005887,GO:0005905,GO:0006897,GO:0007165,GO:0016021,GO:0031175,GO:0040008 neuron migration|low-density lipoprotein receptor activity|integral component of plasma membrane|clathrin-coated pit|endocytosis|signal transduction|integral component of membrane|neuron projection development|regulation of growth LRP1B 74.9308603018774 66.9750689330331 82.8866516707217 1.23757471236944 0.307515623302355 0.36213838803729 1 0.10495 0.0858969 0.154841 0.0816937 GeneID:53353,Genbank:XM_017004341.1,HGNC:HGNC:6693,MIM:608766 LDL receptor related protein 1B GO:0005509,GO:0006898,GO:0015031,GO:0016021,GO:0043235 calcium ion binding|receptor-mediated endocytosis|protein transport|integral component of membrane|receptor complex LRP2 8.4790526432615 8.71542403075469 8.2426812557683 0.945757914552615 -0.0804571504030559 1 1 0.00979345 0.00909673 0.0210701 0.00650751 GeneID:4036,Genbank:NM_004525.2,HGNC:HGNC:6694,MIM:600073 LDL receptor related protein 2 GO:0001523,GO:0001843,GO:0003139,GO:0003148,GO:0003223,GO:0003281,GO:0005041,GO:0005509,GO:0005764,GO:0005765,GO:0005783,GO:0005794,GO:0005886,GO:0005905,GO:0006629,GO:0006897,GO:0006898,GO:0007605,GO:0008144,GO:0008283,GO:0008584,GO:0009897,GO:0016021,GO:0016324,GO:0017124,GO:0030001,GO:0030139,GO:0030424,GO:0030425,GO:0030514,GO:0030665,GO:0030900,GO:0031526,GO:0031904,GO:0035258,GO:0035904,GO:0042359,GO:0042954,GO:0043235,GO:0050769,GO:0051087,GO:0060068,GO:0060982,GO:0061024,GO:0061156,GO:0070062,GO:0070447,GO:0140058,GO:1904447 retinoid metabolic process|neural tube closure|secondary heart field specification|outflow tract septum morphogenesis|ventricular compact myocardium morphogenesis|ventricular septum development|low-density lipoprotein receptor activity|calcium ion binding|lysosome|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|clathrin-coated pit|lipid metabolic process|endocytosis|receptor-mediated endocytosis|sensory perception of sound|drug binding|cell proliferation|male gonad development|external side of plasma membrane|integral component of membrane|apical plasma membrane|SH3 domain binding|metal ion transport|endocytic vesicle|axon|dendrite|negative regulation of BMP signaling pathway|clathrin-coated vesicle membrane|forebrain development|brush border membrane|endosome lumen|steroid hormone receptor binding|aorta development|vitamin D metabolic process|lipoprotein transporter activity|receptor complex|positive regulation of neurogenesis|chaperone binding|vagina development|coronary artery morphogenesis|membrane organization|pulmonary artery morphogenesis|extracellular exosome|positive regulation of oligodendrocyte progenitor proliferation|neuron projection arborization|folic acid import across plasma membrane hsa04340,hsa04918,hsa04979 Hedgehog signaling pathway|Thyroid hormone synthesis|Cholesterol metabolism LRP2BP 12.6452791833634 14.1444270718627 11.1461312948641 0.788022819039238 -0.343690688000011 0.737842937545371 1 0.0584916 0.0205326 0.0102345 0.0238659 GeneID:55805,Genbank:XM_005263125.5,HGNC:HGNC:25434 LRP2 binding protein GO:0005737 cytoplasm LRP3 122.017370550329 103.028630268922 141.006110831736 1.36861094303288 0.452712387918705 0.182560980030008 1 1.18171 1.51047 1.5898 2.02285 GeneID:4037,Genbank:NM_002333.3,HGNC:HGNC:6695,MIM:603159 LDL receptor related protein 3 GO:0005905,GO:0006898,GO:0016021 clathrin-coated pit|receptor-mediated endocytosis|integral component of membrane LRP4 675.845530203429 676.622514613697 675.068545793162 0.997703344498634 -0.0033171841768478 0.98394613451087 1 2.06228 2.0413 2.05004 2.08964 GeneID:4038,Genbank:XM_011520103.2,HGNC:HGNC:6696,MIM:604270 LDL receptor related protein 4 GO:0001822,GO:0001942,GO:0005509,GO:0005886,GO:0006897,GO:0009954,GO:0009986,GO:0014069,GO:0016021,GO:0016600,GO:0017147,GO:0030279,GO:0030425,GO:0030509,GO:0030971,GO:0031594,GO:0034185,GO:0042475,GO:0042733,GO:0042803,GO:0042813,GO:0043025,GO:0043235,GO:0044332,GO:0048813,GO:0050731,GO:0050771,GO:0050808,GO:0051124,GO:0051290,GO:0060173,GO:0071340,GO:0090090,GO:0097060,GO:0097104,GO:0097105,GO:0097110,GO:1901631,GO:1904395 kidney development|hair follicle development|calcium ion binding|plasma membrane|endocytosis|proximal/distal pattern formation|cell surface|postsynaptic density|integral component of membrane|flotillin complex|Wnt-protein binding|negative regulation of ossification|dendrite|BMP signaling pathway|receptor tyrosine kinase binding|neuromuscular junction|apolipoprotein binding|odontogenesis of dentin-containing tooth|embryonic digit morphogenesis|protein homodimerization activity|Wnt-activated receptor activity|neuronal cell body|receptor complex|Wnt signaling pathway involved in dorsal/ventral axis specification|dendrite morphogenesis|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of axonogenesis|synapse organization|synaptic growth at neuromuscular junction|protein heterotetramerization|limb development|skeletal muscle acetylcholine-gated channel clustering|negative regulation of canonical Wnt signaling pathway|synaptic membrane|postsynaptic membrane assembly|presynaptic membrane assembly|scaffold protein binding|positive regulation of presynaptic membrane organization|positive regulation of skeletal muscle acetylcholine-gated channel clustering LRP5 1120.85881037817 1075.71683024549 1166.00079051084 1.08392911380288 0.116270411203789 0.45644850151291 1 5.87062 6.13188 6.97693 6.56838 GeneID:4041,Genbank:XM_011545029.1,HGNC:HGNC:6697,MIM:603506 LDL receptor related protein 5 hsa04150,hsa04310,hsa04928,hsa05200,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer LRP5L 117.464726433181 124.418267165668 110.511185700695 0.888223154189613 -0.171005914936611 0.54085043156221 1 0.433327 0.463021 0.457195 0.318603 GeneID:91355,Genbank:XM_017029085.1,HGNC:HGNC:25323 LDL receptor related protein 5 like LRP6 543.191319000714 527.01748384861 559.365154152818 1.06137874225346 0.0859395592393659 0.788221050448493 1 2.1695 1.77133 2.66178 1.60571 GeneID:4040,Genbank:XM_011520671.3,HGNC:HGNC:6698,MIM:603507 LDL receptor related protein 6 GO:0001843,GO:0001933,GO:0003344,GO:0005041,GO:0005102,GO:0005109,GO:0005576,GO:0005783,GO:0005886,GO:0006469,GO:0007204,GO:0007268,GO:0009880,GO:0009986,GO:0014029,GO:0014033,GO:0016021,GO:0016055,GO:0017147,GO:0019210,GO:0019534,GO:0021587,GO:0021794,GO:0021987,GO:0030917,GO:0031410,GO:0031901,GO:0034185,GO:0034392,GO:0035261,GO:0042475,GO:0042802,GO:0042803,GO:0042813,GO:0043025,GO:0043235,GO:0043434,GO:0044332,GO:0044335,GO:0044340,GO:0045121,GO:0045202,GO:0045787,GO:0045893,GO:0045944,GO:0051091,GO:0060021,GO:0060026,GO:0060059,GO:0060070,GO:0060325,GO:0060535,GO:0060828,GO:0071397,GO:0071542,GO:0071901,GO:0071936,GO:0072659,GO:0090009,GO:0090090,GO:0090118,GO:0090244,GO:0090245,GO:0090263,GO:0098609,GO:1904886,GO:1904928,GO:1904948,GO:1904953,GO:1990851,GO:1990909,GO:2000055 neural tube closure|negative regulation of protein phosphorylation|pericardium morphogenesis|low-density lipoprotein receptor activity|receptor binding|frizzled binding|extracellular region|endoplasmic reticulum|plasma membrane|negative regulation of protein kinase activity|positive regulation of cytosolic calcium ion concentration|chemical synaptic transmission|embryonic pattern specification|cell surface|neural crest formation|neural crest cell differentiation|integral component of membrane|Wnt signaling pathway|Wnt-protein binding|kinase inhibitor activity|toxin transmembrane transporter activity|cerebellum morphogenesis|thalamus development|cerebral cortex development|midbrain-hindbrain boundary development|cytoplasmic vesicle|early endosome membrane|apolipoprotein binding|negative regulation of smooth muscle cell apoptotic process|external genitalia morphogenesis|odontogenesis of dentin-containing tooth|identical protein binding|protein homodimerization activity|Wnt-activated receptor activity|neuronal cell body|receptor complex|response to peptide hormone|Wnt signaling pathway involved in dorsal/ventral axis specification|canonical Wnt signaling pathway involved in neural crest cell differentiation|canonical Wnt signaling pathway involved in regulation of cell proliferation|membrane raft|synapse|positive regulation of cell cycle|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of DNA binding transcription factor activity|palate development|convergent extension|embryonic retina morphogenesis in camera-type eye|canonical Wnt signaling pathway|face morphogenesis|trachea cartilage morphogenesis|regulation of canonical Wnt signaling pathway|cellular response to cholesterol|dopaminergic neuron differentiation|negative regulation of protein serine/threonine kinase activity|coreceptor activity involved in Wnt signaling pathway|protein localization to plasma membrane|primitive streak formation|negative regulation of canonical Wnt signaling pathway|receptor-mediated endocytosis involved in cholesterol transport|Wnt signaling pathway involved in somitogenesis|axis elongation involved in somitogenesis|positive regulation of canonical Wnt signaling pathway|cell-cell adhesion|beta-catenin destruction complex disassembly|coreceptor activity involved in canonical Wnt signaling pathway|midbrain dopaminergic neuron differentiation|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|Wnt-Frizzled-LRP5/6 complex|Wnt signalosome|positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification hsa04150,hsa04310,hsa04928,hsa05200,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer LRP8 1863.8918769451 1901.61494935403 1826.16880453618 0.960325225228444 -0.0584050209648827 0.679021898560869 1 7.44375 7.51999 7.85376 6.80126 GeneID:7804,Genbank:NM_033300.3,HGNC:HGNC:6700,MIM:602600 LDL receptor related protein 8 GO:0000122,GO:0001523,GO:0004888,GO:0005041,GO:0005509,GO:0005576,GO:0005875,GO:0005886,GO:0005901,GO:0006508,GO:0006629,GO:0006897,GO:0007165,GO:0008035,GO:0014069,GO:0016020,GO:0016021,GO:0019221,GO:0019894,GO:0021541,GO:0021987,GO:0030229,GO:0030424,GO:0030425,GO:0032793,GO:0034185,GO:0038025,GO:0038026,GO:0042493,GO:0043025,GO:0043235,GO:0050731,GO:0050804,GO:0061003,GO:0061098,GO:0071363,GO:0071397,GO:1900006 negative regulation of transcription from RNA polymerase II promoter|retinoid metabolic process|transmembrane signaling receptor activity|low-density lipoprotein receptor activity|calcium ion binding|extracellular region|microtubule associated complex|plasma membrane|caveola|proteolysis|lipid metabolic process|endocytosis|signal transduction|high-density lipoprotein particle binding|postsynaptic density|membrane|integral component of membrane|cytokine-mediated signaling pathway|kinesin binding|ammon gyrus development|cerebral cortex development|very-low-density lipoprotein particle receptor activity|axon|dendrite|positive regulation of CREB transcription factor activity|apolipoprotein binding|reelin receptor activity|reelin-mediated signaling pathway|response to drug|neuronal cell body|receptor complex|positive regulation of peptidyl-tyrosine phosphorylation|modulation of chemical synaptic transmission|positive regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|cellular response to growth factor stimulus|cellular response to cholesterol|positive regulation of dendrite development LRPAP1 3323.28646393885 3117.61666207316 3528.95626580454 1.13194040458388 0.178798003863629 0.197527535854357 1 13.6436 15.1338 16.639 16.6011 GeneID:4043,Genbank:NM_002337.3,HGNC:HGNC:6701,MIM:104225 LDL receptor related protein associated protein 1 GO:0001540,GO:0002091,GO:0005102,GO:0005576,GO:0005768,GO:0005783,GO:0005793,GO:0005794,GO:0005796,GO:0005801,GO:0005886,GO:0008201,GO:0009986,GO:0010916,GO:0031904,GO:0032091,GO:0035473,GO:0045056,GO:0048019,GO:0048237,GO:0048259,GO:0050750,GO:0060548,GO:0070326,GO:1900116,GO:1900222,GO:1900223 amyloid-beta binding|negative regulation of receptor internalization|receptor binding|extracellular region|endosome|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|Golgi lumen|cis-Golgi network|plasma membrane|heparin binding|cell surface|negative regulation of very-low-density lipoprotein particle clearance|endosome lumen|negative regulation of protein binding|lipase binding|transcytosis|receptor antagonist activity|rough endoplasmic reticulum lumen|regulation of receptor-mediated endocytosis|low-density lipoprotein particle receptor binding|negative regulation of cell death|very-low-density lipoprotein particle receptor binding|extracellular negative regulation of signal transduction|negative regulation of amyloid-beta clearance|positive regulation of amyloid-beta clearance hsa04979 Cholesterol metabolism LRPPRC 966.845637464725 1068.0735335646 865.617741364847 0.810447702487226 -0.303209002045988 0.253007275346744 1 6.02213 4.87907 5.07921 4.0171 GeneID:10128,Genbank:NM_133259.3,HGNC:HGNC:15714,MIM:607544 leucine rich pentatricopeptide repeat containing GO:0000794,GO:0000961,GO:0003697,GO:0003723,GO:0004519,GO:0005634,GO:0005637,GO:0005640,GO:0005654,GO:0005739,GO:0005856,GO:0005874,GO:0006351,GO:0006355,GO:0008017,GO:0009451,GO:0016020,GO:0030529,GO:0031625,GO:0042645,GO:0047497,GO:0048471,GO:0048487,GO:0051028,GO:0070129 condensed nuclear chromosome|negative regulation of mitochondrial RNA catabolic process|single-stranded DNA binding|RNA binding|endonuclease activity|nucleus|nuclear inner membrane|nuclear outer membrane|nucleoplasm|mitochondrion|cytoskeleton|microtubule|transcription, DNA-templated|regulation of transcription, DNA-templated|microtubule binding|RNA modification|membrane|intracellular ribonucleoprotein complex|ubiquitin protein ligase binding|mitochondrial nucleoid|mitochondrion transport along microtubule|perinuclear region of cytoplasm|beta-tubulin binding|mRNA transport|regulation of mitochondrial translation LRR1 401.974109416834 421.097468443483 382.850750390185 0.909173716492121 -0.137372117324842 0.476350365651942 1 10.8857 9.9886 9.35261 9.08146 GeneID:122769,Genbank:NM_152329.3,HGNC:HGNC:19742,MIM:609193 leucine rich repeat protein 1 GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0016567,GO:0043687 cytoplasm|cytosol|plasma membrane|signal transduction|protein ubiquitination|post-translational protein modification LRRC1 408.336121460079 437.202181123175 379.470061796983 0.867950980532901 -0.204314529336378 0.280247721835527 1 1.61223 1.4792 1.35192 1.28192 GeneID:55227,Genbank:XM_011514726.2,HGNC:HGNC:14307,MIM:608195 leucine rich repeat containing 1 GO:0005737,GO:0005829,GO:0005886,GO:0007165 cytoplasm|cytosol|plasma membrane|signal transduction LRRC10B 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0853439 0 GeneID:390205,Genbank:NM_001145077.1,HGNC:HGNC:37215 leucine rich repeat containing 10B LRRC14 889.90853878026 862.923031594084 916.894045966436 1.06254441288078 0.087523145159725 0.578536558606872 1 9.35847 8.80724 10.1228 9.99728 GeneID:9684,Genbank:NM_001272036.1,HGNC:HGNC:20419 leucine rich repeat containing 14 GO:0005737,GO:0019900,GO:0032088,GO:0034122 cytoplasm|kinase binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway LRRC15 12.7432995245755 13.856269423753 11.6303296253979 0.839355043534351 -0.252646901388284 0.796308209994289 1 0.0938868 0.0912329 0.0745986 0.0825544 GeneID:131578,Genbank:NM_130830.4,HGNC:HGNC:20818 leucine rich repeat containing 15 GO:0001968,GO:0004860,GO:0005518,GO:0005737,GO:0006469,GO:0016021,GO:0019221,GO:0030335,GO:0043236,GO:0046426,GO:0046813,GO:0070062,GO:1903077 fibronectin binding|protein kinase inhibitor activity|collagen binding|cytoplasm|negative regulation of protein kinase activity|integral component of membrane|cytokine-mediated signaling pathway|positive regulation of cell migration|laminin binding|negative regulation of JAK-STAT cascade|receptor-mediated virion attachment to host cell|extracellular exosome|negative regulation of protein localization to plasma membrane LRRC17 76.1930445119351 86.9523265536992 65.4337624701709 0.752524573678439 -0.410189401061313 0.227684338111879 1 0.966186 0.871654 0.875322 0.518009 GeneID:10234,Genbank:NM_005824.2,HGNC:HGNC:16895 leucine rich repeat containing 17 GO:0001503,GO:0005615,GO:0045671,GO:0048539 ossification|extracellular space|negative regulation of osteoclast differentiation|bone marrow development LRRC19 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0126925 0.0118106 GeneID:64922,Genbank:NM_022901.2,HGNC:HGNC:23379 leucine rich repeat containing 19 GO:0004860,GO:0005737,GO:0006469,GO:0016021,GO:0019221,GO:0046426 protein kinase inhibitor activity|cytoplasm|negative regulation of protein kinase activity|integral component of membrane|cytokine-mediated signaling pathway|negative regulation of JAK-STAT cascade LRRC2 201.109876644053 171.992393774254 230.227359513853 1.33859035543185 0.420714524808964 0.0756485419193366 0.94157495521624 1.26996 1.05449 1.84218 1.30591 GeneID:79442,Genbank:XM_011534110.2,HGNC:HGNC:14676,MIM:607180 leucine rich repeat containing 2 LRRC20 929.926706816774 862.039958340394 997.813455293154 1.15750255616242 0.211015379454218 0.181929808399602 1 8.66213 9.75996 11.0069 11.0351 GeneID:55222,Genbank:NM_001278214.1,HGNC:HGNC:23421 leucine rich repeat containing 20 LRRC23 108.642773261241 96.6096757687916 120.675870753691 1.24910750184583 0.320897644844846 0.275831872893477 1 1.14619 1.3529 1.51627 1.29416 GeneID:10233,Genbank:NM_001135217.1,HGNC:HGNC:19138 leucine rich repeat containing 23 LRRC24 45.3910787782683 43.2889625056638 47.4931950508728 1.09712019650873 0.133721590834825 0.794607774757361 1 1.3135 1.62532 1.55214 1.39509 GeneID:441381,Genbank:NM_001024678.3,HGNC:HGNC:28947 leucine rich repeat containing 24 GO:0016021,GO:0051965 integral component of membrane|positive regulation of synapse assembly LRRC25 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0217532 0 0.0201525 0 GeneID:126364,Genbank:XM_005259739.4,HGNC:HGNC:29806,MIM:607518 leucine rich repeat containing 25 GO:0016021 integral component of membrane LRRC26 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.125848 0 GeneID:389816,Genbank:NM_001013653.2,HGNC:HGNC:31409,MIM:613505 leucine rich repeat containing 26 GO:0005249,GO:0005737,GO:0005856,GO:0005887,GO:0008076,GO:0015459,GO:0044325,GO:0070062,GO:0071805,GO:0099104,GO:1903818 voltage-gated potassium channel activity|cytoplasm|cytoskeleton|integral component of plasma membrane|voltage-gated potassium channel complex|potassium channel regulator activity|ion channel binding|extracellular exosome|potassium ion transmembrane transport|potassium channel activator activity|positive regulation of voltage-gated potassium channel activity LRRC27 198.82149839395 188.789091609751 208.853905178148 1.10628163628158 0.145718712464728 0.517518910523398 1 0.599982 0.489768 0.497365 0.658483 GeneID:80313,Genbank:XM_011540208.1,HGNC:HGNC:29346 leucine rich repeat containing 27 GO:0005886,GO:0007165 plasma membrane|signal transduction LRRC28 374.713503863978 406.310099491355 343.1169082366 0.844470537813695 -0.243881004236701 0.18781122956521 1 0.715148 0.865212 0.745975 0.649112 GeneID:123355,Genbank:NM_001321676.1,HGNC:HGNC:28355 leucine rich repeat containing 28 GO:0007165 signal transduction LRRC29 21.5475482418268 15.4705624536799 27.6245340299736 1.78561924381764 0.8364244804488 0.17279287003496 1 0.17939 0.185351 0.363426 0.368877 GeneID:26231,Genbank:XM_017023126.1,HGNC:HGNC:13605 leucine rich repeat containing 29 LRRC3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00731191 GeneID:81543,Genbank:NM_030891.5,HGNC:HGNC:14965,MIM:617620 leucine rich repeat containing 3 LRRC32 6.39108833318931 3.57457863775636 9.20759802862226 2.57585549562886 1.36505166115936 0.268877637743954 1 0.0273233 0.0320399 0.0507785 0.0712446 GeneID:2615,Genbank:XM_005273902.3,HGNC:HGNC:4161,MIM:137207 leucine rich repeat containing 32 GO:0005654,GO:0005887,GO:0010628,GO:0046007,GO:0050710 nucleoplasm|integral component of plasma membrane|positive regulation of gene expression|negative regulation of activated T cell proliferation|negative regulation of cytokine secretion LRRC36 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:55282,Genbank:NM_018296.5,HGNC:HGNC:25615 leucine rich repeat containing 36 LRRC37A 8.8730489949953 6.12098819691306 11.6251097930775 1.89922107658046 0.925407850470192 0.473585517410646 1 0.0421934 0.0777702 0.0512098 0.117433 GeneID:9884,Genbank:NM_014834.4,HGNC:HGNC:29069,MIM:616555 leucine rich repeat containing 37A GO:0016021 integral component of membrane LRRC37A2 33.6355383846739 38.6764061341999 28.5946706351479 0.739331119234031 -0.435707455701515 0.391915519413085 1 0.168171 0.0886971 0.154503 0.106353 GeneID:474170,Genbank:XM_024450773.1,HGNC:HGNC:32404,MIM:616556 leucine rich repeat containing 37 member A2 GO:0016021 integral component of membrane LRRC37A3 72.8561878466627 68.1571254907956 77.5552502025298 1.13788910028202 0.186359958110643 0.601313295601278 1 0.282655 0.264615 0.42246 0.278363 GeneID:374819,Genbank:NM_001303255.2,HGNC:HGNC:32427,MIM:616557 leucine rich repeat containing 37 member A3 GO:0016021 integral component of membrane LRRC37B 177.529627824371 166.025293056504 189.033962592239 1.13858532704354 0.187242412941191 0.462901693787833 1 1.20706 1.13108 1.79921 1.21329 GeneID:114659,Genbank:NM_001321350.1,HGNC:HGNC:29070,MIM:616558 leucine rich repeat containing 37B GO:0016021 integral component of membrane LRRC39 4.05964694034353 7.14915727551272 0.97013660517434 0.135699435302291 -2.88151337772882 0.0956797379829557 1 0.0918316 0.107028 0.0177045 0 GeneID:127495,Genbank:NM_001256387.1,HGNC:HGNC:28228 leucine rich repeat containing 39 GO:0031430 M band LRRC3B 2.79827416923378 2.69048838321152 2.90605995525603 1.08012358402648 0.111196390038603 1 1 0.0185603 0 0 0.0132644 GeneID:116135,Genbank:NM_052953.3,HGNC:HGNC:28105 leucine rich repeat containing 3B GO:0016021 integral component of membrane LRRC4 43.522182146185 43.9133040765681 43.1310602158019 0.982186631654902 -0.025930908453131 1 1 0.443926 0.348955 0.343534 0.399772 GeneID:64101,Genbank:XM_011516461.3,HGNC:HGNC:15586,MIM:610486 leucine rich repeat containing 4 GO:0004860,GO:0005737,GO:0006469,GO:0016021,GO:0019221,GO:0030054,GO:0043197,GO:0045211,GO:0046426,GO:0050807,GO:0060076,GO:0097119 protein kinase inhibitor activity|cytoplasm|negative regulation of protein kinase activity|integral component of membrane|cytokine-mediated signaling pathway|cell junction|dendritic spine|postsynaptic membrane|negative regulation of JAK-STAT cascade|regulation of synapse organization|excitatory synapse|postsynaptic density protein 95 clustering hsa04360,hsa04514 Axon guidance|Cell adhesion molecules (CAMs) LRRC40 199.012648821221 224.515260677099 173.510036965343 0.772820682398457 -0.371794390472459 0.124376144680347 1 3.47932 2.95548 2.65217 2.15285 GeneID:55631,Genbank:NM_017768.4,HGNC:HGNC:26004 leucine rich repeat containing 40 GO:0005886,GO:0007165,GO:0016020 plasma membrane|signal transduction|membrane LRRC41 1611.80331105352 1673.82409334324 1549.7825287638 0.925893309175822 -0.111082133789384 0.42360429693178 1 26.3392 27.8598 24.6783 25.4676 GeneID:10489,Genbank:NM_006369.4,HGNC:HGNC:16917 leucine rich repeat containing 41 GO:0005634,GO:0005737,GO:0005829,GO:0016020,GO:0016567,GO:0042803,GO:0043687 nucleus|cytoplasm|cytosol|membrane|protein ubiquitination|protein homodimerization activity|post-translational protein modification LRRC42 808.196414998829 804.64376938159 811.749060616069 1.00883035636992 0.0126835930759876 0.93728688434451 1 14.1137 14.2027 14.6396 14.3225 GeneID:115353,Genbank:NM_001256409.1,HGNC:HGNC:28792 leucine rich repeat containing 42 LRRC43 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:254050,Genbank:NM_152759.4,HGNC:HGNC:28562 leucine rich repeat containing 43 LRRC45 743.837276302849 724.88085172469 762.793700881007 1.05230218051161 0.0735490503763658 0.743465226665744 1 10.9537 13.2586 12.9393 13.1032 GeneID:201255,Genbank:NM_144999.3,HGNC:HGNC:28302 leucine rich repeat containing 45 GO:0005654,GO:0005813,GO:0005829,GO:0005886 nucleoplasm|centrosome|cytosol|plasma membrane LRRC46 12.4504317810084 8.90752912949446 15.9933344325223 1.79548494313259 0.844373554668389 0.295839451107214 1 0.170099 0.0947354 0.276922 0.27823 GeneID:90506,Genbank:NM_033413.3,HGNC:HGNC:25047 leucine rich repeat containing 46 GO:0031647,GO:1903955 regulation of protein stability|positive regulation of protein targeting to mitochondrion LRRC47 1675.05998130335 1716.4789056229 1633.6410569838 0.951739664048457 -0.0713610977720119 0.598070491977587 1 29.4475 32.0055 29.8336 29.818 GeneID:57470,Genbank:NM_020710.2,HGNC:HGNC:29207 leucine rich repeat containing 47 GO:0003723 RNA binding LRRC49 81.1813995325951 85.2900072490874 77.0727918161028 0.903655589933456 -0.14615507155071 0.677634738777367 1 0.594402 0.597282 0.7353 0.494983 GeneID:54839,Genbank:NM_001284357.1,HGNC:HGNC:25965 leucine rich repeat containing 49 GO:0005737,GO:0005874 cytoplasm|microtubule LRRC4B 1.6955641289216 0 3.3911282578432 Inf Inf 0.190761613265799 1 0 0 0.007737 0.0362344 GeneID:94030,Genbank:NM_001080457.1,HGNC:HGNC:25042 leucine rich repeat containing 4B GO:0004860,GO:0005102,GO:0005737,GO:0005886,GO:0006469,GO:0016021,GO:0019221,GO:0030054,GO:0042734,GO:0044300,GO:0046426,GO:0051965 protein kinase inhibitor activity|receptor binding|cytoplasm|plasma membrane|negative regulation of protein kinase activity|integral component of membrane|cytokine-mediated signaling pathway|cell junction|presynaptic membrane|cerebellar mossy fiber|negative regulation of JAK-STAT cascade|positive regulation of synapse assembly hsa04514 Cell adhesion molecules (CAMs) LRRC4C 103.804889467581 93.7074649766245 113.902313958538 1.21550950062465 0.281561169755369 0.332596294463992 1 0.231251 0.210986 0.324935 0.231339 GeneID:57689,Genbank:XM_017018075.2,HGNC:HGNC:29317,MIM:608817 leucine rich repeat containing 4C GO:0004860,GO:0005615,GO:0005737,GO:0006469,GO:0016020,GO:0016021,GO:0019221,GO:0030054,GO:0045211,GO:0046426,GO:0050770 protein kinase inhibitor activity|extracellular space|cytoplasm|negative regulation of protein kinase activity|membrane|integral component of membrane|cytokine-mediated signaling pathway|cell junction|postsynaptic membrane|negative regulation of JAK-STAT cascade|regulation of axonogenesis hsa04360,hsa04514 Axon guidance|Cell adhesion molecules (CAMs) LRRC56 23.3676843261628 25.9061407188394 20.8292279334862 0.804026665320275 -0.314684746110777 0.701888566876325 1 0.120607 0.207025 0.0404375 0.170505 GeneID:115399,Genbank:XM_017017167.1,HGNC:HGNC:25430 leucine rich repeat containing 56 LRRC57 431.746155298263 414.707939908676 448.784370687851 1.08216970908895 0.113926764656293 0.529302028758359 1 5.51073 5.43757 6.95098 6.05145 GeneID:255252,Genbank:XM_011521423.3,HGNC:HGNC:26719 leucine rich repeat containing 57 GO:0016020,GO:0070062 membrane|extracellular exosome LRRC58 393.382757741856 421.77964494418 364.985870539533 0.865347284807536 -0.208648857491512 0.454319192406616 1 2.63009 2.38137 2.69445 1.75686 GeneID:116064,Genbank:NM_001099678.1,HGNC:HGNC:26968 leucine rich repeat containing 58 LRRC59 10193.2402248802 10170.0529542549 10216.4274955055 1.00455991148317 0.00656360829437167 0.962340834359662 1 142.451 142.811 146.611 139.68 GeneID:55379,Genbank:NM_018509.3,HGNC:HGNC:28817,MIM:614854 leucine rich repeat containing 59 GO:0003723,GO:0005635,GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0031090,GO:0042645,GO:0045296 RNA binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|organelle membrane|mitochondrial nucleoid|cadherin binding LRRC6 16.4147019119389 20.2271976491987 12.6022061746791 0.623032730150747 -0.682620139686497 0.326703248146425 1 0.0469155 0.108104 0.0449084 0.0358927 GeneID:23639,Genbank:XM_011516950.2,HGNC:HGNC:16725,MIM:614930 leucine rich repeat containing 6 GO:0003341,GO:0005737,GO:0005929,GO:0008584,GO:0030317,GO:0036158,GO:0036159,GO:0044458,GO:0060287,GO:0061458 cilium movement|cytoplasm|cilium|male gonad development|flagellated sperm motility|outer dynein arm assembly|inner dynein arm assembly|motile cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry|reproductive system development LRRC61 2.24334138475269 2.54640955915669 1.94027321034868 0.761964312995765 -0.392204664976756 0.964564217020165 1 0.0469079 0.0599435 0.0860951 0 GeneID:65999,Genbank:XM_006716095.3,HGNC:HGNC:21704 leucine rich repeat containing 61 LRRC63 10.3968359274243 9.64754055998448 11.1461312948641 1.1553339657462 0.208309943487242 0.882433175531834 1 0.0197851 0.0352427 0.0192822 0.0358502 GeneID:220416,Genbank:XM_017020421.1,HGNC:HGNC:34296 leucine rich repeat containing 63 LRRC66 9.98010889557446 8.81147658012458 11.1487412110243 1.26525232288216 0.339425122999067 0.743509517222037 1 0.105704 0.0595054 0.131232 0.0846568 GeneID:339977,Genbank:NM_001024611.2,HGNC:HGNC:34299 leucine rich repeat containing 66 GO:0004860,GO:0005737,GO:0006469,GO:0016021,GO:0019221,GO:0046426 protein kinase inhibitor activity|cytoplasm|negative regulation of protein kinase activity|integral component of membrane|cytokine-mediated signaling pathway|negative regulation of JAK-STAT cascade LRRC69 4.50558444100256 4.65077399104097 4.36039489096415 0.937563274277315 -0.093012036492078 1 1 0 0.0909714 0.0299573 0.0279922 GeneID:100130742,Genbank:NM_001354470.1,HGNC:HGNC:34303 leucine rich repeat containing 69 LRRC7 7.61247323651233 10.3777433353665 4.84720313765811 0.467076798974129 -1.09826831071324 0.328565535391971 1 0.0241304 0.0128433 0.0154735 0.00960905 GeneID:57554,Genbank:XM_017001890.1,HGNC:HGNC:18531,MIM:614453 leucine rich repeat containing 7 GO:0005576,GO:0005737,GO:0005886,GO:0007165,GO:0010976,GO:0014069,GO:0030054,GO:0035580,GO:0043005,GO:0043312,GO:0045211 extracellular region|cytoplasm|plasma membrane|signal transduction|positive regulation of neuron projection development|postsynaptic density|cell junction|specific granule lumen|neuron projection|neutrophil degranulation|postsynaptic membrane LRRC70 1.48335117242078 1.02816907859967 1.93853326624189 1.88542264749112 0.914887962799843 0.868258168018795 1 0.0234126 0.0230973 0.0227205 0.0424387 GeneID:100130733,Genbank:NM_181506.4,HGNC:HGNC:35155 leucine rich repeat containing 70 GO:0002224,GO:0002237,GO:0005149,GO:0005578,GO:0005615,GO:0005886,GO:0007409,GO:0016021 toll-like receptor signaling pathway|response to molecule of bacterial origin|interleukin-1 receptor binding|proteinaceous extracellular matrix|extracellular space|plasma membrane|axonogenesis|integral component of membrane LRRC73 8.1729395666706 6.169014471598 10.1768646617432 1.6496743051256 0.722181221585585 0.508025376317755 1 0.176237 0.0886606 0.256183 0.269508 GeneID:221424,Genbank:NM_001271882.1,HGNC:HGNC:21375 leucine rich repeat containing 73 LRRC74B 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0 0 0 GeneID:400891,Genbank:NM_001291006.1,HGNC:HGNC:34301 leucine rich repeat containing 74B LRRC75A 352.115582728486 317.503348534304 386.727816922669 1.21802752225426 0.284546732399528 0.14669262271859 1 2.50346 3.16457 3.59129 3.57 GeneID:388341,Genbank:NM_207387.3,HGNC:HGNC:32403 leucine rich repeat containing 75A LRRC75B 9.95522578617859 8.76345030543964 11.1470012669175 1.27198773067708 0.347084754760084 0.743851322930748 1 0.112544 0.220853 0.136301 0.286457 GeneID:388886,Genbank:NM_207644.2,HGNC:HGNC:33155 leucine rich repeat containing 75B LRRC8A 2241.27982435872 2132.56878184147 2349.99086687597 1.10195314068452 0.140062876232636 0.315594926361396 1 15.6324 15.0936 17.9035 16.7958 GeneID:56262,Genbank:NM_019594.3,HGNC:HGNC:19027,MIM:608360 leucine rich repeat containing 8 VRAC subunit A LRRC8B 182.001835948532 198.234718415888 165.768953481176 0.836225635982695 -0.258035822447458 0.322231130981776 1 0.627961 0.589074 0.636712 0.44224 GeneID:23507,Genbank:XM_011541146.3,HGNC:HGNC:30692,MIM:612888 leucine rich repeat containing 8 VRAC subunit B GO:0005225,GO:0005737,GO:0005789,GO:0005886,GO:0007165,GO:0034702,GO:0055085,GO:0098656 volume-sensitive anion channel activity|cytoplasm|endoplasmic reticulum membrane|plasma membrane|signal transduction|ion channel complex|transmembrane transport|anion transmembrane transport LRRC8C 220.792879008987 217.173998302846 224.411759715127 1.03332701644231 0.0472968953829891 0.840588727291015 1 1.1522 0.946611 1.25877 0.859272 GeneID:84230,Genbank:XM_011542282.2,HGNC:HGNC:25075,MIM:612889 leucine rich repeat containing 8 VRAC subunit C GO:0005225,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0007165,GO:0016020,GO:0034702,GO:0045444,GO:0055085,GO:0098656 volume-sensitive anion channel activity|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|signal transduction|membrane|ion channel complex|fat cell differentiation|transmembrane transport|anion transmembrane transport LRRC8D 1050.01988212435 997.468085065731 1102.57167918297 1.10537038296349 0.14452986294776 0.329904878020875 1 9.54562 8.91217 10.9877 9.4977 GeneID:55144,Genbank:NM_001134479.1,HGNC:HGNC:16992,MIM:612890 leucine rich repeat containing 8 VRAC subunit D GO:0005225,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0007165,GO:0016020,GO:0034702,GO:0055085,GO:0098656 volume-sensitive anion channel activity|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|signal transduction|membrane|ion channel complex|transmembrane transport|anion transmembrane transport LRRC8E 269.98290380151 283.602177904984 256.363629698036 0.90395508099351 -0.14567701034203 0.475677229118189 1 2.5788 2.65203 2.38214 2.323 GeneID:80131,Genbank:NM_001268284.2,HGNC:HGNC:26272,MIM:612891 leucine rich repeat containing 8 VRAC subunit E GO:0005225,GO:0005737,GO:0005789,GO:0005886,GO:0005887,GO:0007165,GO:0034702,GO:0055085,GO:0098656 volume-sensitive anion channel activity|cytoplasm|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|signal transduction|ion channel complex|transmembrane transport|anion transmembrane transport LRRCC1 120.856825226304 129.73160034719 111.982050105418 0.863182523037793 -0.212262440188817 0.693319748535889 1 0.979785 0.695277 0.982922 0.532949 GeneID:85444,Genbank:NM_001349637.1,HGNC:HGNC:29373,MIM:617791 leucine rich repeat and coiled-coil centrosomal protein 1 GO:0005813,GO:0005814,GO:0007049,GO:0051301 centrosome|centriole|cell cycle|cell division LRRFIP1 1038.07117855812 1056.80494232215 1019.3374147941 0.964546411520631 -0.0520774361259833 0.829959712926265 1 3.87708 4.01357 4.67746 3.08523 GeneID:9208,Genbank:XM_017005253.2,HGNC:HGNC:6702,MIM:603256 LRR binding FLII interacting protein 1 GO:0000122,GO:0000978,GO:0001078,GO:0003677,GO:0003725,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006351,GO:0006357,GO:0032481,GO:0042803,GO:0045296,GO:0045892 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|double-stranded RNA binding|nucleus|cytoplasm|cytosol|cytoskeleton|plasma membrane|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon production|protein homodimerization activity|cadherin binding|negative regulation of transcription, DNA-templated LRRFIP2 1850.42089751394 1962.41119516035 1738.43059986753 0.885864595633579 -0.174841895132573 0.217632553775036 1 9.91297 10.3401 9.24616 8.28601 GeneID:9209,Genbank:NM_017724.2,HGNC:HGNC:6703,MIM:614043 LRR binding FLII interacting protein 2 GO:0002756,GO:0016055,GO:0035660,GO:0051092,GO:1904469 MyD88-independent toll-like receptor signaling pathway|Wnt signaling pathway|MyD88-dependent toll-like receptor 4 signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of tumor necrosis factor secretion LRRIQ1 4.27816795429465 7.10113100082778 1.45520490776151 0.204925793875916 -2.28682650802575 0.151678250297273 1 0.0105883 0.0211865 0.00344953 0 GeneID:84125,Genbank:NM_001079910.1,HGNC:HGNC:25708 leucine rich repeats and IQ motif containing 1 LRRIQ3 10.7603057374836 9.88767193340919 11.6329395415581 1.17650945742363 0.234512917777113 0.820432638088467 1 0.0957056 0.0529906 0.113876 0.0768576 GeneID:127255,Genbank:NM_001322315.1,HGNC:HGNC:28318 leucine rich repeats and IQ motif containing 3 LRRK1 3.48665995556497 4.06465003971372 2.90866987141623 0.715601550686289 -0.482771581218901 0.844722203344029 1 0.00695769 0.0156431 0.00326727 0.00610048 GeneID:79705,Genbank:XM_011522014.2,HGNC:HGNC:18608,MIM:610986 leucine rich repeat kinase 1 GO:0004674,GO:0004871,GO:0005524,GO:0005525,GO:0005737,GO:0005739,GO:0005829,GO:0035556,GO:0036035,GO:0042802,GO:0045453,GO:0046872,GO:0050731,GO:0050732,GO:0090263,GO:1902533 protein serine/threonine kinase activity|signal transducer activity|ATP binding|GTP binding|cytoplasm|mitochondrion|cytosol|intracellular signal transduction|osteoclast development|identical protein binding|bone resorption|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of peptidyl-tyrosine phosphorylation|positive regulation of canonical Wnt signaling pathway|positive regulation of intracellular signal transduction LRRK2 23.0809063869695 20.9574004245808 25.2044123493581 1.2026497484772 0.266216543005409 0.685601284771944 1 0.067863 0.0833466 0.0963074 0.0772232 GeneID:120892,Genbank:XM_005268629.4,HGNC:HGNC:18618,MIM:609007 leucine rich repeat kinase 2 GO:0000149,GO:0000165,GO:0000186,GO:0000187,GO:0001933,GO:0001934,GO:0003779,GO:0003924,GO:0004672,GO:0004674,GO:0004708,GO:0005096,GO:0005524,GO:0005525,GO:0005615,GO:0005622,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005759,GO:0005764,GO:0005768,GO:0005783,GO:0005794,GO:0005798,GO:0005802,GO:0005829,GO:0005886,GO:0005902,GO:0006468,GO:0006897,GO:0006914,GO:0006979,GO:0007005,GO:0007030,GO:0007040,GO:0007283,GO:0007528,GO:0008017,GO:0008340,GO:0009267,GO:0010506,GO:0010508,GO:0010738,GO:0010955,GO:0010977,GO:0014041,GO:0015631,GO:0016234,GO:0016242,GO:0016301,GO:0016310,GO:0017048,GO:0017075,GO:0018105,GO:0018107,GO:0019722,GO:0021756,GO:0021772,GO:0022028,GO:0030054,GO:0030159,GO:0030276,GO:0030424,GO:0030425,GO:0030426,GO:0030529,GO:0030672,GO:0031398,GO:0031410,GO:0031966,GO:0032091,GO:0032092,GO:0032436,GO:0032473,GO:0032839,GO:0033160,GO:0034211,GO:0034260,GO:0034599,GO:0034613,GO:0035556,GO:0035564,GO:0035640,GO:0035641,GO:0035751,GO:0036479,GO:0039706,GO:0040012,GO:0042391,GO:0042802,GO:0042803,GO:0043005,GO:0043025,GO:0043068,GO:0043195,GO:0043204,GO:0043231,GO:0043406,GO:0044325,GO:0044753,GO:0044754,GO:0046039,GO:0046777,GO:0048312,GO:0048812,GO:0051018,GO:0051646,GO:0051770,GO:0051900,GO:0051966,GO:0060070,GO:0060079,GO:0060159,GO:0060161,GO:0060828,GO:0061001,GO:0070062,GO:0070585,GO:0070997,GO:0071287,GO:0072593,GO:0090140,GO:0090263,GO:0090394,GO:0097487,GO:0098794,GO:0099400,GO:0140058,GO:1900244,GO:1901214,GO:1901215,GO:1901727,GO:1902236,GO:1902499,GO:1902692,GO:1902803,GO:1902823,GO:1902902,GO:1903125,GO:1903206,GO:1903215,GO:1903217,GO:1903351,GO:1903980,GO:1904469,GO:1904713,GO:1904887,GO:1905279,GO:1905289,GO:1990909,GO:2000172,GO:2000300 SNARE binding|MAPK cascade|activation of MAPKK activity|activation of MAPK activity|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|actin binding|GTPase activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase activity|GTPase activator activity|ATP binding|GTP binding|extracellular space|intracellular|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial matrix|lysosome|endosome|endoplasmic reticulum|Golgi apparatus|Golgi-associated vesicle|trans-Golgi network|cytosol|plasma membrane|microvillus|protein phosphorylation|endocytosis|autophagy|response to oxidative stress|mitochondrion organization|Golgi organization|lysosome organization|spermatogenesis|neuromuscular junction development|microtubule binding|determination of adult lifespan|cellular response to starvation|regulation of autophagy|positive regulation of autophagy|regulation of protein kinase A signaling|negative regulation of protein processing|negative regulation of neuron projection development|regulation of neuron maturation|tubulin binding|inclusion body|negative regulation of macroautophagy|kinase activity|phosphorylation|Rho GTPase binding|syntaxin-1 binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|calcium-mediated signaling|striatum development|olfactory bulb development|tangential migration from the subventricular zone to the olfactory bulb|cell junction|receptor signaling complex scaffold activity|clathrin binding|axon|dendrite|growth cone|intracellular ribonucleoprotein complex|synaptic vesicle membrane|positive regulation of protein ubiquitination|cytoplasmic vesicle|mitochondrial membrane|negative regulation of protein binding|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cytoplasmic side of mitochondrial outer membrane|dendrite cytoplasm|positive regulation of protein import into nucleus, translocation|GTP-dependent protein kinase activity|negative regulation of GTPase activity|cellular response to oxidative stress|cellular protein localization|intracellular signal transduction|regulation of kidney size|exploration behavior|locomotory exploration behavior|regulation of lysosomal lumen pH|peroxidase inhibitor activity|co-receptor binding|regulation of locomotion|regulation of membrane potential|identical protein binding|protein homodimerization activity|neuron projection|neuronal cell body|positive regulation of programmed cell death|terminal bouton|perikaryon|intracellular membrane-bounded organelle|positive regulation of MAP kinase activity|ion channel binding|amphisome|autolysosome|GTP metabolic process|protein autophosphorylation|intracellular distribution of mitochondria|neuron projection morphogenesis|protein kinase A binding|mitochondrion localization|positive regulation of nitric-oxide synthase biosynthetic process|regulation of mitochondrial depolarization|regulation of synaptic transmission, glutamatergic|canonical Wnt signaling pathway|excitatory postsynaptic potential|regulation of dopamine receptor signaling pathway|positive regulation of dopamine receptor signaling pathway|regulation of canonical Wnt signaling pathway|regulation of dendritic spine morphogenesis|extracellular exosome|protein localization to mitochondrion|neuron death|cellular response to manganese ion|reactive oxygen species metabolic process|regulation of mitochondrial fission|positive regulation of canonical Wnt signaling pathway|negative regulation of excitatory postsynaptic potential|multivesicular body, internal vesicle|postsynapse|caveola neck|neuron projection arborization|positive regulation of synaptic vesicle endocytosis|regulation of neuron death|negative regulation of neuron death|positive regulation of histone deacetylase activity|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of protein autoubiquitination|regulation of neuroblast proliferation|regulation of synaptic vesicle transport|negative regulation of late endosome to lysosome transport|negative regulation of autophagosome assembly|negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation|negative regulation of hydrogen peroxide-induced cell death|negative regulation of protein targeting to mitochondrion|negative regulation of protein processing involved in protein targeting to mitochondrion|cellular response to dopamine|positive regulation of microglial cell activation|positive regulation of tumor necrosis factor secretion|beta-catenin destruction complex binding|Wnt signalosome assembly|regulation of retrograde transport, endosome to Golgi|regulation of CAMKK-AMPK signaling cascade|Wnt signalosome|regulation of branching morphogenesis of a nerve|regulation of synaptic vesicle exocytosis hsa05012 Parkinson disease LRRN1 434.824294694664 435.837828121781 433.810761267547 0.995349034151144 -0.0067255777336273 0.997904390512395 1 3.02147 2.79995 3.56054 2.44538 GeneID:57633,Genbank:NM_001324188.1,HGNC:HGNC:20980 leucine rich repeat neuronal 1 GO:0005578,GO:0005615,GO:0016021,GO:0051965 proteinaceous extracellular matrix|extracellular space|integral component of membrane|positive regulation of synapse assembly LRRN4 1.59027989258444 3.18055978516888 0 0 -Inf 0.214127562460916 1 0.0413482 0.00747029 0 0 GeneID:164312,Genbank:XM_011529183.3,HGNC:HGNC:16208 leucine rich repeat neuronal 4 GO:0005887,GO:0007616,GO:0008542,GO:0070062 integral component of plasma membrane|long-term memory|visual learning|extracellular exosome LRRN4CL 2.29093267341093 2.64246210852658 1.93940323829528 0.733937955831913 -0.446269986310634 0.964756719484364 1 0.0217878 0.019322 0.0609625 0.0190057 GeneID:221091,Genbank:NM_203422.3,HGNC:HGNC:33724 LRRN4 C-terminal like GO:0016021 integral component of membrane LRRTM2 8.49425617346859 7.29323609956755 9.69527624736962 1.32935176031728 0.410722907260263 0.710687572614066 1 0.0619749 0.033202 0.0862743 0.0433202 GeneID:26045,Genbank:NM_015564.2,HGNC:HGNC:19409,MIM:610868 leucine rich repeat transmembrane neuronal 2 GO:0002091,GO:0016021,GO:0030054,GO:0042043,GO:0045211,GO:0050808,GO:0051965,GO:0060076,GO:0060291 negative regulation of receptor internalization|integral component of membrane|cell junction|neurexin family protein binding|postsynaptic membrane|synapse organization|positive regulation of synapse assembly|excitatory synapse|long-term synaptic potentiation LRSAM1 300.039402906636 284.572512053791 315.506293759481 1.10870263428621 0.148872471389872 0.462413173098426 1 2.09051 2.02232 2.47825 2.07613 GeneID:90678,Genbank:NM_138361.5,HGNC:HGNC:25135,MIM:610933 leucine rich repeat and sterile alpha motif containing 1 GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0005886,GO:0006914,GO:0007165,GO:0016020,GO:0030163,GO:0045806,GO:0046755,GO:0046872,GO:0051865,GO:0061630,GO:0070086,GO:1904417,GO:2000786 protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|plasma membrane|autophagy|signal transduction|membrane|protein catabolic process|negative regulation of endocytosis|viral budding|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|ubiquitin-dependent endocytosis|positive regulation of xenophagy|positive regulation of autophagosome assembly LRTM2 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0200654 0.0107487 0 GeneID:654429,Genbank:XM_011521015.1,HGNC:HGNC:32443 leucine rich repeats and transmembrane domains 2 GO:0004860,GO:0005737,GO:0006469,GO:0016021,GO:0019221,GO:0046426,GO:0051965 protein kinase inhibitor activity|cytoplasm|negative regulation of protein kinase activity|integral component of membrane|cytokine-mediated signaling pathway|negative regulation of JAK-STAT cascade|positive regulation of synapse assembly LRTOMT 216.897854985329 208.478191582308 225.31751838835 1.08077260589338 0.112063012564322 0.688138394436168 1 0.44773 0.569031 0.643585 0.672628 GeneID:220074,Genbank:NM_001145309.3,HGNC:HGNC:25033,MIM:612414 leucine rich transmembrane and O-methyltransferase domain containing GO:0005737 cytoplasm hsa00140,hsa00350,hsa04728 Steroid hormone biosynthesis|Tyrosine metabolism|Dopaminergic synapse LRWD1 1068.63658877052 1105.0720710874 1032.20110645364 0.934057726604156 -0.0984163808068163 0.506051427918239 1 19.6322 19.2528 18.3483 20.2586 GeneID:222229,Genbank:NM_001317721.1,HGNC:HGNC:21769,MIM:615167 leucine rich repeats and WD repeat domain containing 1 GO:0000776,GO:0000777,GO:0003682,GO:0005634,GO:0005664,GO:0005721,GO:0005730,GO:0005737,GO:0005815,GO:0006270,GO:0006325,GO:0008327,GO:0016569,GO:0031933,GO:0035064,GO:0043231,GO:0071169 kinetochore|condensed chromosome kinetochore|chromatin binding|nucleus|nuclear origin of replication recognition complex|pericentric heterochromatin|nucleolus|cytoplasm|microtubule organizing center|DNA replication initiation|chromatin organization|methyl-CpG binding|covalent chromatin modification|telomeric heterochromatin|methylated histone binding|intracellular membrane-bounded organelle|establishment of protein localization to chromatin LSAMP 369.369734841192 295.248221692375 443.491247990009 1.50209625462907 0.586977264001744 0.0108588485330438 0.417063112962181 0.540943 0.560219 0.917774 0.69123 GeneID:4045,Genbank:NM_002338.4,HGNC:HGNC:6705,MIM:603241 limbic system associated membrane protein GO:0005576,GO:0005829,GO:0005886,GO:0006501,GO:0007155,GO:0007399,GO:0031225,GO:0035641 extracellular region|cytosol|plasma membrane|C-terminal protein lipidation|cell adhesion|nervous system development|anchored component of membrane|locomotory exploration behavior LSG1 2057.91699242001 2011.0145078484 2104.81947699162 1.04664559543312 0.0657730141249074 0.645469391857131 1 14.5218 15.5244 17.055 15.134 GeneID:55341,Genbank:NM_018385.2,HGNC:HGNC:25652,MIM:610780 large 60S subunit nuclear export GTPase 1 GO:0003924,GO:0005525,GO:0005634,GO:0005783,GO:0005829,GO:0015030,GO:0015031,GO:0016020,GO:0016604,GO:0042254,GO:0051168 GTPase activity|GTP binding|nucleus|endoplasmic reticulum|cytosol|Cajal body|protein transport|membrane|nuclear body|ribosome biogenesis|nuclear export hsa03008 Ribosome biogenesis in eukaryotes LSM1 906.713009976462 886.868886705094 926.55713324783 1.04475097405907 0.0631591037376461 0.690436791705877 1 28.056 28.8937 28.6857 31.7853 GeneID:27257,Genbank:NM_014462.2,HGNC:HGNC:20472,MIM:607281 LSM1 homolog, mRNA degradation associated GO:0000290,GO:0000339,GO:0000932,GO:0003729,GO:0005634,GO:0005737,GO:0005845,GO:0006397,GO:0008380,GO:0019827,GO:0030424,GO:0030425,GO:0036002,GO:0043025,GO:0045665,GO:0071044,GO:1990124,GO:1990726 deadenylation-dependent decapping of nuclear-transcribed mRNA|RNA cap binding|P-body|mRNA binding|nucleus|cytoplasm|mRNA cap binding complex|mRNA processing|RNA splicing|stem cell population maintenance|axon|dendrite|pre-mRNA binding|neuronal cell body|negative regulation of neuron differentiation|histone mRNA catabolic process|messenger ribonucleoprotein complex|Lsm1-7-Pat1 complex hsa03018 RNA degradation LSM10 965.556213304383 988.572398593054 942.540028015712 0.953435508979559 -0.0687927379140666 0.653518557781409 1 43.6878 47.9909 42.542 47.3594 GeneID:84967,Genbank:NM_032881.2,HGNC:HGNC:17562,MIM:617909 LSM10, U7 small nuclear RNA associated GO:0005634,GO:0005654,GO:0005683,GO:0006369,GO:0006397,GO:0008334,GO:0008380,GO:0015030,GO:0016604,GO:0071208,GO:0071209,GO:1900087 nucleus|nucleoplasm|U7 snRNP|termination of RNA polymerase II transcription|mRNA processing|histone mRNA metabolic process|RNA splicing|Cajal body|nuclear body|histone pre-mRNA DCP binding|U7 snRNA binding|positive regulation of G1/S transition of mitotic cell cycle LSM11 347.77688315216 388.782181879621 306.771584424698 0.789057726209491 -0.34179724551083 0.0793993690585808 0.945472338172662 2.96874 2.67061 2.33862 2.20135 GeneID:134353,Genbank:NM_173491.3,HGNC:HGNC:30860,MIM:617910 LSM11, U7 small nuclear RNA associated GO:0005634,GO:0005654,GO:0005683,GO:0006369,GO:0006398,GO:0008334,GO:0016604,GO:0071204,GO:0071209,GO:1900087 nucleus|nucleoplasm|U7 snRNP|termination of RNA polymerase II transcription|mRNA 3'-end processing by stem-loop binding and cleavage|histone mRNA metabolic process|nuclear body|histone pre-mRNA 3'end processing complex|U7 snRNA binding|positive regulation of G1/S transition of mitotic cell cycle LSM12 746.872151213466 787.6461747931 706.098127633833 0.896466142071104 -0.157678998785935 0.316153405885379 1 9.2308 10.3 8.4751 8.67194 GeneID:124801,Genbank:NM_152344.3,HGNC:HGNC:26407,MIM:611793 LSM12 homolog LSM14A 2078.01286039634 2306.15381733373 1849.87190345895 0.802145932138077 -0.318063368905822 0.0251158245866728 0.631315976879816 15.9575 14.6683 13.0919 11.8509 GeneID:26065,Genbank:NM_001114093.1,HGNC:HGNC:24489,MIM:610677 LSM14A, mRNA processing body assembly factor GO:0000932,GO:0003690,GO:0003723,GO:0003725,GO:0003727,GO:0005737,GO:0005829,GO:0006417,GO:0007275,GO:0010494,GO:0033962,GO:0036464,GO:0039529,GO:0060340 P-body|double-stranded DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|cytoplasm|cytosol|regulation of translation|multicellular organism development|cytoplasmic stress granule|cytoplasmic mRNA processing body assembly|cytoplasmic ribonucleoprotein granule|RIG-I signaling pathway|positive regulation of type I interferon-mediated signaling pathway LSM14B 1601.05161295806 1639.72980061433 1562.37342530178 0.952823705903517 -0.0697187875165766 0.623757071144528 1 18.8139 19.3311 17.5094 19.0836 GeneID:149986,Genbank:XM_011528607.2,HGNC:HGNC:15887 LSM family member 14B GO:0003723,GO:0006417,GO:0007275,GO:0030529 RNA binding|regulation of translation|multicellular organism development|intracellular ribonucleoprotein complex LSM2 1181.91112598483 1211.9154113675 1151.90684060216 0.950484522102388 -0.0732649609834874 0.612113730254 1 70.5086 74.7438 66.9101 71.8271 GeneID:57819,Genbank:NM_021177.4,HGNC:HGNC:13940,MIM:607282 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated GO:0000398,GO:0000932,GO:0003723,GO:0005654,GO:0005688,GO:0005829,GO:0017070,GO:0017160,GO:0043928,GO:0046540,GO:0071011,GO:0071013,GO:1990726 mRNA splicing, via spliceosome|P-body|RNA binding|nucleoplasm|U6 snRNP|cytosol|U6 snRNA binding|Ral GTPase binding|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|U4/U6 x U5 tri-snRNP complex|precatalytic spliceosome|catalytic step 2 spliceosome|Lsm1-7-Pat1 complex hsa03018,hsa03040 RNA degradation|Spliceosome LSM3 2718.51910243507 2739.7570788581 2697.28112601205 0.984496452925035 -0.0225420866850444 0.861882006584604 1 155.366 167.703 152.371 164.992 GeneID:27258,Genbank:NM_014463.2,HGNC:HGNC:17874,MIM:607283 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated GO:0000398,GO:0000932,GO:0000956,GO:0003723,GO:0005688,GO:0030629,GO:0033962,GO:0046540,GO:0071011,GO:0071013,GO:1990726 mRNA splicing, via spliceosome|P-body|nuclear-transcribed mRNA catabolic process|RNA binding|U6 snRNP|U6 snRNA 3'-end binding|cytoplasmic mRNA processing body assembly|U4/U6 x U5 tri-snRNP complex|precatalytic spliceosome|catalytic step 2 spliceosome|Lsm1-7-Pat1 complex hsa03018,hsa03040 RNA degradation|Spliceosome LSM4 7035.5758413595 6817.63868507123 7253.51299764777 1.06393332540942 0.0894077428361261 0.519806484779689 1 172.787 185.229 184.381 197.632 GeneID:25804,Genbank:NM_001252129.1,HGNC:HGNC:17259,MIM:607284 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated GO:0000245,GO:0000387,GO:0000398,GO:0000932,GO:0000956,GO:0003723,GO:0005654,GO:0005681,GO:0005688,GO:0005829,GO:0008380,GO:0016020,GO:0017070,GO:0033962,GO:0042731,GO:0043005,GO:0043234,GO:0043928,GO:0097526 spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|P-body|nuclear-transcribed mRNA catabolic process|RNA binding|nucleoplasm|spliceosomal complex|U6 snRNP|cytosol|RNA splicing|membrane|U6 snRNA binding|cytoplasmic mRNA processing body assembly|PH domain binding|neuron projection|protein complex|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|spliceosomal tri-snRNP complex hsa03018,hsa03040 RNA degradation|Spliceosome LSM5 1813.45185369731 1948.69900456066 1678.20470283397 0.861192364190863 -0.215592567059889 0.129411061131349 1 35.0723 36.4248 30.2313 31.2682 GeneID:23658,Genbank:NM_001130710.1,HGNC:HGNC:17162,MIM:607285 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated GO:0000398,GO:0000956,GO:0003723,GO:0005634,GO:0005654,GO:0005681,GO:0005688,GO:0005829,GO:0006397,GO:0043928,GO:0046540,GO:1990726 mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process|RNA binding|nucleus|nucleoplasm|spliceosomal complex|U6 snRNP|cytosol|mRNA processing|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|U4/U6 x U5 tri-snRNP complex|Lsm1-7-Pat1 complex hsa03018,hsa03040 RNA degradation|Spliceosome LSM6 307.892770017074 325.007290041972 290.778249992176 0.894682239141849 -0.160552718001393 0.425570898600932 1 8.46396 7.6744 6.84056 7.12669 GeneID:11157,Genbank:NM_007080.2,HGNC:HGNC:17017,MIM:607286 LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated GO:0000398,GO:0000932,GO:0003723,GO:0005654,GO:0005681,GO:0005688,GO:0005730,GO:0005732,GO:0005829,GO:0008033,GO:0008380,GO:0030490,GO:0030532,GO:0043928,GO:0046540,GO:0070062 mRNA splicing, via spliceosome|P-body|RNA binding|nucleoplasm|spliceosomal complex|U6 snRNP|nucleolus|small nucleolar ribonucleoprotein complex|cytosol|tRNA processing|RNA splicing|maturation of SSU-rRNA|small nuclear ribonucleoprotein complex|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|U4/U6 x U5 tri-snRNP complex|extracellular exosome hsa03018,hsa03040 RNA degradation|Spliceosome LSM7 1695.76564923559 1709.43560955186 1682.09568891931 0.98400646360718 -0.0232603027137018 0.847216105642932 1 32.0971 36.0937 35.8174 35.7546 GeneID:51690,Genbank:XM_017026869.2,HGNC:HGNC:20470,MIM:607287 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated GO:0000398,GO:0005654,GO:0005688,GO:0005689,GO:0005829,GO:0006396,GO:0017070,GO:0043928,GO:0071004,GO:0071013,GO:0097526,GO:1990726 mRNA splicing, via spliceosome|nucleoplasm|U6 snRNP|U12-type spliceosomal complex|cytosol|RNA processing|U6 snRNA binding|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|U2-type prespliceosome|catalytic step 2 spliceosome|spliceosomal tri-snRNP complex|Lsm1-7-Pat1 complex hsa03018,hsa03040 RNA degradation|Spliceosome LSM8 835.105330429883 860.876502091993 809.334158767774 0.940128063434223 -0.0890708020362176 0.56647525604502 1 2.56421 2.93674 2.64755 2.52202 GeneID:51691,Genbank:NM_016200.4,HGNC:HGNC:20471,MIM:607288 LSM8 homolog, U6 small nuclear RNA associated GO:0000398,GO:0003723,GO:0005654,GO:0005688,GO:0017070,GO:0046540,GO:0071011 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|U6 snRNP|U6 snRNA binding|U4/U6 x U5 tri-snRNP complex|precatalytic spliceosome hsa03018,hsa03040 RNA degradation|Spliceosome LSMEM1 31.597000767647 28.2986627988333 34.8953387364607 1.23310910428953 0.302300453636739 0.561466425089463 1 0.156568 0.152317 0.214861 0.188211 GeneID:286006,Genbank:XM_017012028.2,HGNC:HGNC:22036 leucine rich single-pass membrane protein 1 GO:0005829,GO:0016021 cytosol|integral component of membrane LSMEM2 26.5240031262538 32.6994967613416 20.348509491166 0.622288154453272 -0.68434531077709 0.277123484087741 1 0.214106 0.0412334 0.115077 0.174452 GeneID:132228,Genbank:XM_011533370.3,HGNC:HGNC:26781 leucine rich single-pass membrane protein 2 GO:0016021 integral component of membrane LSP1 39.0586031981809 51.4662888597762 26.6509175365856 0.517832509921166 -0.949442553307611 0.0358398350882696 0.738653561785664 0.450797 0.54519 0.214081 0.323151 GeneID:4046,Genbank:NM_002339.2,HGNC:HGNC:6707,MIM:153432 lymphocyte-specific protein 1 GO:0003779,GO:0004871,GO:0005886,GO:0006928,GO:0006968,GO:0015629,GO:0016020,GO:0070062 actin binding|signal transducer activity|plasma membrane|movement of cell or subcellular component|cellular defense response|actin cytoskeleton|membrane|extracellular exosome hsa04625,hsa05152 C-type lectin receptor signaling pathway|Tuberculosis LSR 45.8703598750533 38.4362747607751 53.3044449893315 1.38682651534507 0.471787325437019 0.269764449746645 1 0.720675 0.628938 0.925759 1.01094 GeneID:51599,Genbank:NM_205834.3,HGNC:HGNC:29572,MIM:616582 lipolysis stimulated lipoprotein receptor GO:0001889,GO:0005886,GO:0016021,GO:0019216,GO:0034361,GO:0034362,GO:0042627,GO:0060856,GO:0061689,GO:0061833,GO:0070062,GO:1904274 liver development|plasma membrane|integral component of membrane|regulation of lipid metabolic process|very-low-density lipoprotein particle|low-density lipoprotein particle|chylomicron|establishment of blood-brain barrier|tricellular tight junction|protein localization to tricellular tight junction|extracellular exosome|tricellular tight junction assembly LSS 3159.7986824089 2737.82520221474 3581.77216260307 1.30825450788664 0.387643230093077 0.0044735802173683 0.264386940078859 21.7051 21.5644 28.1632 29.4954 GeneID:4047,Genbank:NM_001001438.2,HGNC:HGNC:6708,MIM:600909 lanosterol synthase GO:0000250,GO:0005789,GO:0005811,GO:0006694,GO:0006695,GO:0016020,GO:0031647,GO:0045540 lanosterol synthase activity|endoplasmic reticulum membrane|lipid droplet|steroid biosynthetic process|cholesterol biosynthetic process|membrane|regulation of protein stability|regulation of cholesterol biosynthetic process hsa00100 Steroid biosynthesis LST1 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0 0 0.0503049 0 GeneID:7940,Genbank:NM_205839.2,HGNC:HGNC:14189,MIM:109170 leukocyte specific transcript 1 GO:0000139,GO:0000902,GO:0005737,GO:0005794,GO:0006955,GO:0008360,GO:0009653,GO:0016021,GO:0016358,GO:0050672 Golgi membrane|cell morphogenesis|cytoplasm|Golgi apparatus|immune response|regulation of cell shape|anatomical structure morphogenesis|integral component of membrane|dendrite development|negative regulation of lymphocyte proliferation LTA 1.75577153248042 2.05633815719933 1.45520490776151 0.707668095671314 -0.498855216219501 0.969173888295735 1 0.0284805 0 0.026819 0 GeneID:4049,Genbank:XM_011514618.1,HGNC:HGNC:6709,MIM:153440 lymphotoxin alpha hsa04060,hsa04064,hsa04668,hsa04940,hsa05166,hsa05168 Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|TNF signaling pathway|Type I diabetes mellitus|Human T-cell leukemia virus 1 infection|Herpes simplex infection LTA4H 1051.88646211234 1103.49497867619 1000.27794554849 0.906463522605674 -0.141679129870773 0.355835526598125 1 12.9585 13.408 12.4407 11.8361 GeneID:4048,Genbank:NM_001256644.1,HGNC:HGNC:6710,MIM:151570 leukotriene A4 hydrolase GO:0003723,GO:0004177,GO:0004301,GO:0004463,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006691,GO:0008233,GO:0008270,GO:0019370,GO:0042277,GO:0043171,GO:0043312,GO:0044255,GO:0044267,GO:0070006,GO:0070062,GO:1904724,GO:1904813 RNA binding|aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|leukotriene metabolic process|peptidase activity|zinc ion binding|leukotriene biosynthetic process|peptide binding|peptide catabolic process|neutrophil degranulation|cellular lipid metabolic process|cellular protein metabolic process|metalloaminopeptidase activity|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen hsa00590 Arachidonic acid metabolism LTB4R 70.8759396747221 75.3445003858853 66.4073789635589 0.881383228018581 -0.182158651283858 0.640384335276108 1 0.698976 0.525127 0.651149 0.416599 GeneID:1241,Genbank:NM_001143919.2,HGNC:HGNC:6713,MIM:601531 leukotriene B4 receptor GO:0000166,GO:0001632,GO:0004974,GO:0005886,GO:0005887,GO:0006928,GO:0006936,GO:0006954,GO:0006955,GO:0007186,GO:0007200,GO:0007218,GO:0008528,GO:0045121 nucleotide binding|leukotriene B4 receptor activity|leukotriene receptor activity|plasma membrane|integral component of plasma membrane|movement of cell or subcellular component|muscle contraction|inflammatory response|immune response|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|G-protein coupled peptide receptor activity|membrane raft hsa04080 Neuroactive ligand-receptor interaction LTB4R2 22.8098768506113 16.0566864050072 29.5630672962155 1.84116862910123 0.880621766409148 0.136430484543922 1 1.03783 1.07295 0.988218 1.1399 GeneID:56413,Genbank:NM_001164692.2,HGNC:HGNC:19260,MIM:605773 leukotriene B4 receptor 2 GO:0001632,GO:0004974,GO:0005654,GO:0005886,GO:0005887,GO:0006935,GO:0007186,GO:0007194,GO:0007200,GO:0007218,GO:0008528,GO:0016020,GO:0051546 leukotriene B4 receptor activity|leukotriene receptor activity|nucleoplasm|plasma membrane|integral component of plasma membrane|chemotaxis|G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|phospholipase C-activating G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|G-protein coupled peptide receptor activity|membrane|keratinocyte migration hsa04020,hsa04080 Calcium signaling pathway|Neuroactive ligand-receptor interaction LTBP1 1073.62103099673 952.595272496319 1194.64678949714 1.25409691186742 0.326648838465496 0.0318801922938646 0.70845034327151 4.85816 5.37244 6.9251 6.07298 GeneID:4052,Genbank:XM_024452888.1,HGNC:HGNC:6714,MIM:150390 latent transforming growth factor beta binding protein 1 GO:0001527,GO:0003281,GO:0005024,GO:0005509,GO:0005576,GO:0005578,GO:0005615,GO:0005788,GO:0031012,GO:0035583,GO:0035904,GO:0043234,GO:0043687,GO:0044267,GO:0050431,GO:0050436,GO:0060976 microfibril|ventricular septum development|transforming growth factor beta-activated receptor activity|calcium ion binding|extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|extracellular matrix|sequestering of TGFbeta in extracellular matrix|aorta development|protein complex|post-translational protein modification|cellular protein metabolic process|transforming growth factor beta binding|microfibril binding|coronary vasculature development hsa04350 TGF-beta signaling pathway LTBP2 182.26996739648 214.79128487796 149.748649914999 0.697182150570414 -0.520392461185654 0.0280042207517585 0.668561867500627 0.827687 0.833703 0.591032 0.619682 GeneID:4053,Genbank:XM_011536765.2,HGNC:HGNC:6715,MIM:602091 latent transforming growth factor beta binding protein 2 GO:0005509,GO:0005576,GO:0005578,GO:0005615,GO:0005622,GO:0006605,GO:0007179,GO:0008201,GO:0009306,GO:0019838,GO:0031012,GO:0070062,GO:0097435 calcium ion binding|extracellular region|proteinaceous extracellular matrix|extracellular space|intracellular|protein targeting|transforming growth factor beta receptor signaling pathway|heparin binding|protein secretion|growth factor binding|extracellular matrix|extracellular exosome|supramolecular fiber organization LTBP3 2929.78938320721 3117.24022652908 2742.33853988535 0.879732821534523 -0.184862657016625 0.170933155413757 1 23.1567 22.9379 20.2403 22.1354 GeneID:4054,Genbank:XM_011545033.3,HGNC:HGNC:6716,MIM:602090 latent transforming growth factor beta binding protein 3 GO:0005509,GO:0005576,GO:0031012,GO:0036363,GO:0050431,GO:0070062,GO:1902462,GO:2000741 calcium ion binding|extracellular region|extracellular matrix|transforming growth factor beta activation|transforming growth factor beta binding|extracellular exosome|positive regulation of mesenchymal stem cell proliferation|positive regulation of mesenchymal stem cell differentiation LTBP4 1870.74872820502 1900.40550083265 1841.09195557739 0.968789005699429 -0.0457456021847173 0.732565347430404 1 13.1101 13.401 13.6681 13.575 GeneID:8425,Genbank:XM_011527387.1,HGNC:HGNC:6717,MIM:604710 latent transforming growth factor beta binding protein 4 GO:0001558,GO:0005024,GO:0005178,GO:0005509,GO:0005539,GO:0005576,GO:0005578,GO:0005615,GO:0006457,GO:0007179,GO:0007275,GO:0017015,GO:0030162,GO:0030252,GO:0031012,GO:0045595,GO:0050431,GO:0070062 regulation of cell growth|transforming growth factor beta-activated receptor activity|integrin binding|calcium ion binding|glycosaminoglycan binding|extracellular region|proteinaceous extracellular matrix|extracellular space|protein folding|transforming growth factor beta receptor signaling pathway|multicellular organism development|regulation of transforming growth factor beta receptor signaling pathway|regulation of proteolysis|growth hormone secretion|extracellular matrix|regulation of cell differentiation|transforming growth factor beta binding|extracellular exosome LTBR 1103.00887330062 1065.70469679825 1140.313049803 1.07000846785128 0.0976222138962403 0.544115676795243 1 13.8696 15.9605 16.2944 16.5013 GeneID:4055,Genbank:NM_001270987.1,HGNC:HGNC:6718,MIM:600979 lymphotoxin beta receptor GO:0005031,GO:0005794,GO:0005886,GO:0005887,GO:0006915,GO:0006954,GO:0006955,GO:0007165,GO:0007275,GO:0016032,GO:0031625,GO:0032496,GO:0033209,GO:0042127,GO:0042802,GO:0043011,GO:0043123,GO:0046330,GO:0071260,GO:2001238 tumor necrosis factor-activated receptor activity|Golgi apparatus|plasma membrane|integral component of plasma membrane|apoptotic process|inflammatory response|immune response|signal transduction|multicellular organism development|viral process|ubiquitin protein ligase binding|response to lipopolysaccharide|tumor necrosis factor-mediated signaling pathway|regulation of cell proliferation|identical protein binding|myeloid dendritic cell differentiation|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade|cellular response to mechanical stimulus|positive regulation of extrinsic apoptotic signaling pathway hsa04060,hsa04064,hsa04066,hsa04672,hsa05166,hsa05203 Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|HIF-1 signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Viral carcinogenesis LTC4S 1.22224196918161 1.96028560782945 0.484198330533773 0.247003971564076 -2.01739385587201 0.637784766456736 1 0 0 0 0 GeneID:4056,Genbank:NM_145867.1,HGNC:HGNC:6719,MIM:246530 leukotriene C4 synthase GO:0004364,GO:0004464,GO:0004602,GO:0005635,GO:0005640,GO:0005783,GO:0005789,GO:0006691,GO:0008047,GO:0008289,GO:0016021,GO:0019370,GO:0019372,GO:0042802,GO:0043231,GO:2001301 glutathione transferase activity|leukotriene-C4 synthase activity|glutathione peroxidase activity|nuclear envelope|nuclear outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|leukotriene metabolic process|enzyme activator activity|lipid binding|integral component of membrane|leukotriene biosynthetic process|lipoxygenase pathway|identical protein binding|intracellular membrane-bounded organelle|lipoxin biosynthetic process hsa00590 Arachidonic acid metabolism LTF 86.4237370804865 98.704231545568 74.143242615405 0.751165795573576 -0.412796723695278 0.198004956482328 1 0.851535 0.788853 0.634791 0.777003 GeneID:4057,Genbank:NM_001321122.1,HGNC:HGNC:6720,MIM:150210 lactotransferrin LTK 1.47997965068228 0.538097676642304 2.42186162472226 4.50078439259304 2.1701764549285 0.55105548931329 1 0.016776 0 0 0.0434 GeneID:4058,Genbank:XM_017022181.1,HGNC:HGNC:6721,MIM:151520 leukocyte receptor tyrosine kinase GO:0004672,GO:0004713,GO:0004714,GO:0005524,GO:0005622,GO:0005886,GO:0005887,GO:0006468,GO:0007165,GO:0007169,GO:0008283,GO:0010666,GO:0010976,GO:0014065,GO:0016020,GO:0043066,GO:0071300 protein kinase activity|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|ATP binding|intracellular|plasma membrane|integral component of plasma membrane|protein phosphorylation|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|cell proliferation|positive regulation of cardiac muscle cell apoptotic process|positive regulation of neuron projection development|phosphatidylinositol 3-kinase signaling|membrane|negative regulation of apoptotic process|cellular response to retinoic acid LTN1 158.747191481554 146.39402801374 171.100354949368 1.16876594811169 0.224986051079135 0.385934175559086 1 0.702274 0.666221 0.973253 0.662995 GeneID:26046,Genbank:NM_015565.2,HGNC:HGNC:13082,MIM:613083 listerin E3 ubiquitin protein ligase 1 GO:0008270,GO:0051865,GO:0061630 zinc ion binding|protein autoubiquitination|ubiquitin protein ligase activity LTV1 546.933917262517 623.752638132095 470.115196392939 0.753688509920788 -0.407959696118129 0.0179501644774807 0.546850871863472 8.28288 8.07201 6.52088 5.47765 GeneID:84946,Genbank:NM_001329953.1,HGNC:HGNC:21173 LTV1 ribosome biogenesis factor GO:0000056,GO:0005634,GO:0005654,GO:0005829,GO:0006364,GO:0030688,GO:0031902,GO:0034448,GO:0042274 ribosomal small subunit export from nucleus|nucleus|nucleoplasm|cytosol|rRNA processing|preribosome, small subunit precursor|late endosome membrane|EGO complex|ribosomal small subunit biogenesis LUC7L 527.328577386366 547.28391611824 507.373238654491 0.927075003872165 -0.109242031832571 0.539531844858649 1 5.15444 4.69844 4.17374 4.32124 GeneID:55692,Genbank:NM_201412.2,HGNC:HGNC:6723,MIM:607782 LUC7 like GO:0003729,GO:0005685,GO:0006376,GO:0042802,GO:0045843,GO:0050733,GO:0071004 mRNA binding|U1 snRNP|mRNA splice site selection|identical protein binding|negative regulation of striated muscle tissue development|RS domain binding|U2-type prespliceosome LUC7L2 229.577665588022 233.31794560297 225.837385573073 0.967938342631275 -0.0470129436820859 0.824989937058578 1 13.2344 13.2128 14.0137 12.2767 GeneID:51631,Genbank:NM_001244585.1,HGNC:HGNC:21608,MIM:613056 LUC7 like 2, pre-mRNA splicing factor GO:0003723,GO:0003729,GO:0005685,GO:0006376,GO:0016607,GO:0019899,GO:0071004 RNA binding|mRNA binding|U1 snRNP|mRNA splice site selection|nuclear speck|enzyme binding|U2-type prespliceosome LUC7L3 1064.42020730603 1165.8544402352 962.985974376858 0.825991599931282 -0.27580098491226 0.351999116733575 1 5.61929 4.294 4.55747 3.87549 GeneID:51747,Genbank:NM_001330330.1,HGNC:HGNC:24309,MIM:609434 LUC7 like 3 pre-mRNA splicing factor GO:0003677,GO:0003729,GO:0005634,GO:0005685,GO:0006376,GO:0008380,GO:0016607 DNA binding|mRNA binding|nucleus|U1 snRNP|mRNA splice site selection|RNA splicing|nuclear speck LUM 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0209015 0.0209221 0 GeneID:4060,Genbank:NM_002345.3,HGNC:HGNC:6724,MIM:600616 lumican GO:0005201,GO:0005518,GO:0005576,GO:0005578,GO:0005583,GO:0005615,GO:0005796,GO:0007601,GO:0014070,GO:0018146,GO:0030198,GO:0030199,GO:0031012,GO:0032914,GO:0042340,GO:0043202,GO:0045944,GO:0051216,GO:0070062,GO:0070848 extracellular matrix structural constituent|collagen binding|extracellular region|proteinaceous extracellular matrix|fibrillar collagen trimer|extracellular space|Golgi lumen|visual perception|response to organic cyclic compound|keratan sulfate biosynthetic process|extracellular matrix organization|collagen fibril organization|extracellular matrix|positive regulation of transforming growth factor beta1 production|keratan sulfate catabolic process|lysosomal lumen|positive regulation of transcription from RNA polymerase II promoter|cartilage development|extracellular exosome|response to growth factor hsa05205 Proteoglycans in cancer LURAP1 42.759156626325 40.9346580452469 44.5836552074032 1.0891419969387 0.123192057750417 0.808424884782553 1 0.954749 1.01914 0.997485 1.02402 GeneID:541468,Genbank:NM_001013615.2,HGNC:HGNC:32327,MIM:616129 leucine rich adaptor protein 1 GO:0001819,GO:0005737,GO:0016477,GO:0031032,GO:0042641,GO:0043123,GO:0043231 positive regulation of cytokine production|cytoplasm|cell migration|actomyosin structure organization|actomyosin|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle LURAP1L 516.83971807949 558.699637187314 474.979798971665 0.850152331157536 -0.23420672691314 0.179160497014786 1 7.11336 7.03044 6.95264 5.43797 GeneID:286343,Genbank:XM_005251443.3,HGNC:HGNC:31452,MIM:616130 leucine rich adaptor protein 1 like GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling LUZP1 1371.93140666599 1446.93185989295 1296.93095343903 0.896331741243834 -0.157895308063363 0.289820916647076 1 5.80773 5.3874 5.41513 4.61359 GeneID:7798,Genbank:NM_001142546.1,HGNC:HGNC:14985,MIM:601422 leucine zipper protein 1 GO:0003281,GO:0005634,GO:0016020,GO:0021503,GO:0060840,GO:0070062 ventricular septum development|nucleus|membrane|neural fold bending|artery development|extracellular exosome LVRN 3.70518096951609 4.01662376502878 3.3937381740034 0.844923092760488 -0.243108065613907 0.953366981910967 1 0.0178352 0.0513621 0.0429986 0.0159771 GeneID:206338,Genbank:NM_173800.4,HGNC:HGNC:26904,MIM:610046 laeverin GO:0005737,GO:0005886,GO:0006508,GO:0007165,GO:0007267,GO:0008217,GO:0008270,GO:0016021,GO:0042277,GO:0043171,GO:0070006 cytoplasm|plasma membrane|proteolysis|signal transduction|cell-cell signaling|regulation of blood pressure|zinc ion binding|integral component of membrane|peptide binding|peptide catabolic process|metalloaminopeptidase activity LY6E 1185.94402582978 1035.89760217396 1335.99044948559 1.28969354372657 0.367028293966143 0.45950976636292 1 44.9207 51.405 84.6898 43.7866 GeneID:4061,Genbank:NM_002346.2,HGNC:HGNC:6727,MIM:601384 lymphocyte antigen 6 family member E GO:0005576,GO:0005886,GO:0005887,GO:0006501,GO:0007166,GO:0031225 extracellular region|plasma membrane|integral component of plasma membrane|C-terminal protein lipidation|cell surface receptor signaling pathway|anchored component of membrane LY6G5B 73.103159243971 66.2448661576511 79.9614523302909 1.2070588555496 0.271496022853008 0.430926710560869 1 4.1837 3.55633 5.35478 4.64718 GeneID:58496,Genbank:NM_021221.2,HGNC:HGNC:13931,MIM:610433 lymphocyte antigen 6 family member G5B GO:0005576,GO:0042802,GO:0043234,GO:0051260 extracellular region|identical protein binding|protein complex|protein homooligomerization LY6G5C 17.9132566145668 19.8331787966113 15.9933344325223 0.806392893269077 -0.310445170447647 0.658218245707669 1 1.11968 1.57904 0.726459 0.904982 GeneID:80741,Genbank:NM_025262.3,HGNC:HGNC:13932,MIM:610434 lymphocyte antigen 6 family member G5C GO:0005576,GO:0009897,GO:0042802,GO:0043234,GO:0051260 extracellular region|external side of plasma membrane|identical protein binding|protein complex|protein homooligomerization LY6G6C 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.068128 GeneID:80740,Genbank:NM_025261.2,HGNC:HGNC:13936,MIM:610435 lymphocyte antigen 6 family member G6C GO:0005576,GO:0005886,GO:0006501,GO:0009897,GO:0031225,GO:0042802,GO:0043234,GO:0051260 extracellular region|plasma membrane|C-terminal protein lipidation|external side of plasma membrane|anchored component of membrane|identical protein binding|protein complex|protein homooligomerization LY6K 20.761731988619 22.6197197291927 18.9037442480453 0.835719649684624 -0.258909037559851 0.710471372489532 1 0.377636 0.260624 0.353498 0.22047 GeneID:54742,Genbank:XM_005250990.5,HGNC:HGNC:24225,MIM:615093 lymphocyte antigen 6 family member K GO:0001669,GO:0005576,GO:0005886,GO:0006501,GO:0031225,GO:0045121 acrosomal vesicle|extracellular region|plasma membrane|C-terminal protein lipidation|anchored component of membrane|membrane raft LY96 544.644495874755 506.781494545158 582.507497204352 1.14942535091412 0.200912773700231 0.230758411843681 1 13.8275 12.0947 15.1089 15.5349 GeneID:23643,Genbank:XM_017013300.1,HGNC:HGNC:17156,MIM:605243 lymphocyte antigen 96 GO:0001875,GO:0002224,GO:0002755,GO:0002756,GO:0005615,GO:0005886,GO:0006954,GO:0006968,GO:0007166,GO:0007249,GO:0010008,GO:0015026,GO:0031226,GO:0031666,GO:0032496,GO:0032497,GO:0032760,GO:0034128,GO:0034142,GO:0035666,GO:0045087,GO:0046696,GO:0070266,GO:0097190 lipopolysaccharide receptor activity|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|extracellular space|plasma membrane|inflammatory response|cellular defense response|cell surface receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|endosome membrane|coreceptor activity|intrinsic component of plasma membrane|positive regulation of lipopolysaccharide-mediated signaling pathway|response to lipopolysaccharide|detection of lipopolysaccharide|positive regulation of tumor necrosis factor production|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|innate immune response|lipopolysaccharide receptor complex|necroptotic process|apoptotic signaling pathway hsa04064,hsa04620,hsa05130,hsa05133,hsa05145 NF-kappa B signaling pathway|Toll-like receptor signaling pathway|Pathogenic Escherichia coli infection|Pertussis|Toxoplasmosis LYAR 437.388061106667 519.0430882492 355.733033964134 0.685363203976124 -0.545059356876467 0.00255668204036149 0.183792639730358 7.02556 6.80913 5.09265 4.42238 GeneID:55646,Genbank:XM_011513506.3,HGNC:HGNC:26021,MIM:617684 Ly1 antibody reactive GO:0000122,GO:0001750,GO:0003677,GO:0003723,GO:0005634,GO:0005730,GO:0006364,GO:0046872,GO:0048821,GO:0050766 negative regulation of transcription from RNA polymerase II promoter|photoreceptor outer segment|DNA binding|RNA binding|nucleus|nucleolus|rRNA processing|metal ion binding|erythrocyte development|positive regulation of phagocytosis LYG1 14.255775300184 15.422536178995 13.089014421373 0.848694032515861 -0.236683561523052 0.797879373702428 1 0.113955 0.124048 0.10935 0.0145485 GeneID:129530,Genbank:XM_005263869.2,HGNC:HGNC:27014 lysozyme g1 GO:0003796,GO:0005576,GO:0009253,GO:0016998 lysozyme activity|extracellular region|peptidoglycan catabolic process|cell wall macromolecule catabolic process LYL1 210.581712295776 207.958694215026 213.204730376525 1.02522633728443 0.0359424459559255 0.901554950084062 1 2.44796 1.65636 1.91705 2.50197 GeneID:4066,Genbank:XM_005259912.4,HGNC:HGNC:6734,MIM:151440 LYL1, basic helix-loop-helix family member hsa05202 Transcriptional misregulation in cancer LYN 594.664389705188 613.566999895468 575.761779514908 0.93838452787226 -0.0917488685477743 0.603471636240496 1 2.91485 2.66423 2.73459 2.45694 GeneID:4067,Genbank:XM_011517529.3,HGNC:HGNC:6735,MIM:165120 LYN proto-oncogene, Src family tyrosine kinase GO:0001782,GO:0001817,GO:0001932,GO:0001933,GO:0001934,GO:0002223,GO:0002250,GO:0002431,GO:0002513,GO:0002553,GO:0002576,GO:0002762,GO:0002768,GO:0002774,GO:0002902,GO:0004713,GO:0004715,GO:0004716,GO:0005102,GO:0005161,GO:0005178,GO:0005524,GO:0005634,GO:0005737,GO:0005758,GO:0005794,GO:0005829,GO:0005886,GO:0005913,GO:0006468,GO:0006954,GO:0006974,GO:0006991,GO:0007165,GO:0007169,GO:0007417,GO:0007596,GO:0008284,GO:0008285,GO:0009636,GO:0009725,GO:0009743,GO:0010976,GO:0014003,GO:0014069,GO:0014070,GO:0016032,GO:0016301,GO:0017124,GO:0018108,GO:0019899,GO:0030061,GO:0030168,GO:0030218,GO:0030335,GO:0030889,GO:0031175,GO:0031234,GO:0031295,GO:0031625,GO:0031663,GO:0031668,GO:0032868,GO:0033003,GO:0033628,GO:0034136,GO:0034144,GO:0034605,GO:0034666,GO:0038083,GO:0038095,GO:0038096,GO:0042493,GO:0042531,GO:0042629,GO:0043015,GO:0043200,GO:0043208,GO:0043231,GO:0043304,GO:0043407,GO:0043552,GO:0044325,GO:0045087,GO:0045121,GO:0045646,GO:0046777,GO:0046875,GO:0048013,GO:0048471,GO:0048678,GO:0050663,GO:0050707,GO:0050727,GO:0050777,GO:0050853,GO:0050855,GO:0050861,GO:0050900,GO:0051219,GO:0051272,GO:0051279,GO:0060252,GO:0060369,GO:0060397,GO:0070062,GO:0070304,GO:0070372,GO:0070373,GO:0070447,GO:0070667,GO:0070668,GO:0071300,GO:0090025,GO:0090330,GO:0097028,GO:0140031,GO:1902532,GO:1902961,GO:2000670 B cell homeostasis|regulation of cytokine production|regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|stimulatory C-type lectin receptor signaling pathway|adaptive immune response|Fc receptor mediated stimulatory signaling pathway|tolerance induction to self antigen|histamine secretion by mast cell|platelet degranulation|negative regulation of myeloid leukocyte differentiation|immune response-regulating cell surface receptor signaling pathway|Fc receptor mediated inhibitory signaling pathway|regulation of B cell apoptotic process|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signal transducer, downstream of receptor, with protein tyrosine kinase activity|receptor binding|platelet-derived growth factor receptor binding|integrin binding|ATP binding|nucleus|cytoplasm|mitochondrial intermembrane space|Golgi apparatus|cytosol|plasma membrane|cell-cell adherens junction|protein phosphorylation|inflammatory response|cellular response to DNA damage stimulus|response to sterol depletion|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|central nervous system development|blood coagulation|positive regulation of cell proliferation|negative regulation of cell proliferation|response to toxic substance|response to hormone|response to carbohydrate|positive regulation of neuron projection development|oligodendrocyte development|postsynaptic density|response to organic cyclic compound|viral process|kinase activity|SH3 domain binding|peptidyl-tyrosine phosphorylation|enzyme binding|mitochondrial crista|platelet activation|erythrocyte differentiation|positive regulation of cell migration|negative regulation of B cell proliferation|neuron projection development|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|ubiquitin protein ligase binding|lipopolysaccharide-mediated signaling pathway|cellular response to extracellular stimulus|response to insulin|regulation of mast cell activation|regulation of cell adhesion mediated by integrin|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 4 signaling pathway|cellular response to heat|integrin alpha2-beta1 complex|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|response to drug|positive regulation of tyrosine phosphorylation of STAT protein|mast cell granule|gamma-tubulin binding|response to amino acid|glycosphingolipid binding|intracellular membrane-bounded organelle|regulation of mast cell degranulation|negative regulation of MAP kinase activity|positive regulation of phosphatidylinositol 3-kinase activity|ion channel binding|innate immune response|membrane raft|regulation of erythrocyte differentiation|protein autophosphorylation|ephrin receptor binding|ephrin receptor signaling pathway|perinuclear region of cytoplasm|response to axon injury|cytokine secretion|regulation of cytokine secretion|regulation of inflammatory response|negative regulation of immune response|B cell receptor signaling pathway|regulation of B cell receptor signaling pathway|positive regulation of B cell receptor signaling pathway|leukocyte migration|phosphoprotein binding|positive regulation of cellular component movement|regulation of release of sequestered calcium ion into cytosol|positive regulation of glial cell proliferation|positive regulation of Fc receptor mediated stimulatory signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|extracellular exosome|positive regulation of stress-activated protein kinase signaling cascade|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|positive regulation of oligodendrocyte progenitor proliferation|negative regulation of mast cell proliferation|positive regulation of mast cell proliferation|cellular response to retinoic acid|regulation of monocyte chemotaxis|regulation of platelet aggregation|dendritic cell differentiation|phosphorylation-dependent protein binding|negative regulation of intracellular signal transduction|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of dendritic cell apoptotic process hsa04062,hsa04064,hsa04611,hsa04662,hsa04664,hsa04666,hsa04730,hsa05120,hsa05167,hsa05169,hsa05203 Chemokine signaling pathway|NF-kappa B signaling pathway|Platelet activation|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Long-term depression|Epithelial cell signaling in Helicobacter pylori infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Viral carcinogenesis LYNX1 18.2687867895441 18.6030959641639 17.9344776149243 0.964058759330837 -0.0528070135651816 0.996412773612053 1 0.201221 0.145616 0.212564 0.140974 GeneID:66004,Genbank:NM_177457.4,HGNC:HGNC:29604,MIM:606110 Ly6/neurotoxin 1 GO:0005783,GO:0005886,GO:0007271,GO:0008200,GO:0030425,GO:0030548,GO:0030550,GO:0031225,GO:0033130,GO:0070062,GO:0099601 endoplasmic reticulum|plasma membrane|synaptic transmission, cholinergic|ion channel inhibitor activity|dendrite|acetylcholine receptor regulator activity|acetylcholine receptor inhibitor activity|anchored component of membrane|acetylcholine receptor binding|extracellular exosome|regulation of neurotransmitter receptor activity LYPD1 4202.62712689767 3909.40188814342 4495.85236565191 1.15001028144154 0.201646759359581 0.135225433585502 1 31.8876 33.2196 37.7589 37.9636 GeneID:116372,Genbank:NM_001077427.3,HGNC:HGNC:28431,MIM:610450 LY6/PLAUR domain containing 1 GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0046872 G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|metal ion binding LYPD3 10.5449491069797 9.94550686320207 11.1443913507573 1.12054533811556 0.164201022566475 0.959276322629177 1 0.0985053 0.36683 0.211873 0.311563 GeneID:27076,Genbank:NM_014400.2,HGNC:HGNC:24880,MIM:609484 LY6/PLAUR domain containing 3 LYPD5 10.3121933066911 12.3860552178809 8.23833139550132 0.665129555018306 -0.588292716411745 0.548220164431506 1 0.144066 0.110133 0.0729732 0.0876199 GeneID:284348,Genbank:XM_011526794.2,HGNC:HGNC:26397 LY6/PLAUR domain containing 5 GO:0005576,GO:0005886,GO:0006501,GO:0007160,GO:0031225,GO:0043236 extracellular region|plasma membrane|C-terminal protein lipidation|cell-matrix adhesion|anchored component of membrane|laminin binding LYPD6 389.182478603953 380.950848103411 397.414109104494 1.04321623401824 0.0610382253673779 0.727096262100902 1 2.15941 1.94295 2.32554 1.98925 GeneID:130574,Genbank:NM_001195685.1,HGNC:HGNC:28751,MIM:613359 LY6/PLAUR domain containing 6 GO:0005576,GO:0005737,GO:0005886,GO:0030054,GO:0030550,GO:0031225,GO:0043005,GO:0045121,GO:0045202 extracellular region|cytoplasm|plasma membrane|cell junction|acetylcholine receptor inhibitor activity|anchored component of membrane|neuron projection|membrane raft|synapse LYPD6B 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0187727 GeneID:130576,Genbank:NM_001317005.1,HGNC:HGNC:27018 LY6/PLAUR domain containing 6B GO:0005576,GO:0005886,GO:0006501,GO:0030548,GO:0031225 extracellular region|plasma membrane|C-terminal protein lipidation|acetylcholine receptor regulator activity|anchored component of membrane LYPLA1 1684.82673169268 1836.2423307941 1533.41113259125 0.835081027637628 -0.260011906283304 0.0732572333169286 0.934750619674839 31.7036 29.708 27.3933 24.6665 GeneID:10434,Genbank:NM_001279359.1,HGNC:HGNC:6737,MIM:605599 lysophospholipase I GO:0002084,GO:0004622,GO:0005737,GO:0005739,GO:0005829,GO:0006631,GO:0008474,GO:0016298,GO:0042997,GO:0050999,GO:0070062 protein depalmitoylation|lysophospholipase activity|cytoplasm|mitochondrion|cytosol|fatty acid metabolic process|palmitoyl-(protein) hydrolase activity|lipase activity|negative regulation of Golgi to plasma membrane protein transport|regulation of nitric-oxide synthase activity|extracellular exosome hsa00564,hsa05231 Glycerophospholipid metabolism|Choline metabolism in cancer LYPLA2 1686.71193418201 1717.89905955237 1655.52480881164 0.963691550796362 -0.0533566386232443 0.710296183108508 1 21.6104 19.3466 22.0106 19.6389 GeneID:11313,Genbank:XM_024452796.1,HGNC:HGNC:6738,MIM:616143 lysophospholipase II GO:0002084,GO:0005737,GO:0005795,GO:0005829,GO:0006631,GO:0007411,GO:0008474,GO:0045296,GO:0052689,GO:0070062 protein depalmitoylation|cytoplasm|Golgi stack|cytosol|fatty acid metabolic process|axon guidance|palmitoyl-(protein) hydrolase activity|cadherin binding|carboxylic ester hydrolase activity|extracellular exosome hsa00564 Glycerophospholipid metabolism LYPLAL1 210.188592199218 202.789439857559 217.587744540877 1.07297374406534 0.101614773419517 0.641878837434113 1 0.61273 0.482937 0.449406 0.56055 GeneID:127018,Genbank:NM_001350628.1,HGNC:HGNC:20440,MIM:616548 lysophospholipase like 1 GO:0002084,GO:0004622,GO:0005737,GO:0005829,GO:0008474,GO:0052689,GO:0070062 protein depalmitoylation|lysophospholipase activity|cytoplasm|cytosol|palmitoyl-(protein) hydrolase activity|carboxylic ester hydrolase activity|extracellular exosome LYRM1 314.758725327091 301.897498910822 327.619951743359 1.08520260328535 0.117964413608157 0.549850637177639 1 2.78078 2.52717 3.25146 2.65494 GeneID:57149,Genbank:XM_017023477.1,HGNC:HGNC:25074,MIM:614709 LYR motif containing 1 GO:0005654,GO:0005739,GO:0030496 nucleoplasm|mitochondrion|midbody LYRM2 1200.10436736408 1264.23433051479 1135.97440421337 0.8985473474295 -0.154333568779277 0.314599336633282 1 8.91034 8.20511 7.90574 7.41789 GeneID:57226,Genbank:NM_020466.4,HGNC:HGNC:25229 LYR motif containing 2 GO:0005739 mitochondrion LYRM4 691.003507935023 726.349031928853 655.657983941194 0.902676199898091 -0.147719525316659 0.369075497549321 1 2.69888 2.81954 2.33566 2.67207 GeneID:57128,Genbank:XM_017011084.2,HGNC:HGNC:21365,MIM:613311 LYR motif containing 4 GO:0005759,GO:0016604,GO:0044281 mitochondrial matrix|nuclear body|small molecule metabolic process LYRM7 228.039448117032 234.586246054995 221.49265017907 0.944184298542144 -0.0828596032648095 0.704005068626723 1 1.42793 1.59651 1.61286 1.26467 GeneID:90624,Genbank:NM_181705.3,HGNC:HGNC:28072,MIM:615831 LYR motif containing 7 GO:0005759,GO:0031966,GO:0034551,GO:0045333 mitochondrial matrix|mitochondrial membrane|mitochondrial respiratory chain complex III assembly|cellular respiration LYRM9 23.3158275227327 19.9772576206661 26.6543974247992 1.33423705750412 0.416015016823559 0.498420863096752 1 0.0806242 0.110896 0.136608 0.0886104 GeneID:201229,Genbank:NM_001076680.1,HGNC:HGNC:27314 LYR motif containing 9 LYSMD1 103.902065377846 100.72235208319 107.081778672503 1.06313818589204 0.0883291294600548 0.829743945130675 1 1.22819 1.43153 1.09105 1.70638 GeneID:388695,Genbank:NM_001136543.1,HGNC:HGNC:32070 LysM domain containing 1 GO:0005634,GO:0005654 nucleus|nucleoplasm LYSMD2 237.073942385151 263.817025383058 210.330859387245 0.797260370447464 -0.326877136281483 0.126916866010918 1 6.44845 6.70009 5.80239 5.03215 GeneID:256586,Genbank:NM_001143917.1,HGNC:HGNC:28571 LysM domain containing 2 LYSMD3 220.103917149438 241.494254956228 198.713579342648 0.82285013106695 -0.281298404040411 0.362470157904772 1 2.40872 1.85777 2.01541 1.48922 GeneID:116068,Genbank:XM_005248421.4,HGNC:HGNC:26969 LysM domain containing 3 GO:0016021 integral component of membrane LYSMD4 242.331864409448 225.390559277391 259.273169541505 1.15032843599458 0.202045831022686 0.360534609671604 1 0.952937 1.13082 1.21638 1.19113 GeneID:145748,Genbank:XM_011521245.3,HGNC:HGNC:26571 LysM domain containing 4 GO:0016021 integral component of membrane LYST 297.032832446551 287.253191781894 306.812473111208 1.06809073628733 0.0950342118487754 0.669238556104702 1 0.465113 0.457899 0.585955 0.411334 GeneID:1130,Genbank:NM_001301365.1,HGNC:HGNC:1968,MIM:606897 lysosomal trafficking regulator LYZ 2.02938848414507 3.57457863775636 0.484198330533773 0.135456057790825 -2.88410318049579 0.310124734844215 1 0.100116 0.126015 0 0.029679 GeneID:4069,Genbank:NM_000239.2,HGNC:HGNC:6740,MIM:153450 lysozyme hsa04970 Salivary secretion LYZL1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:84569,Genbank:XM_005252627.3,HGNC:HGNC:30502 lysozyme like 1 GO:0003796,GO:0005615,GO:0016998,GO:0050829,GO:0050830 lysozyme activity|extracellular space|cell wall macromolecule catabolic process|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium LYZL2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:119180,Genbank:NM_183058.2,HGNC:HGNC:29613,MIM:612748 lysozyme like 2 GO:0003796,GO:0005615,GO:0016998,GO:0050829,GO:0050830 lysozyme activity|extracellular space|cell wall macromolecule catabolic process|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium LZIC 619.450794085596 618.073695062454 620.827893108738 1.00445609976332 0.00641451176880195 0.957686802061725 1 4.69436 4.43965 4.92539 4.28261 GeneID:84328,Genbank:NM_001316975.1,HGNC:HGNC:17497,MIM:610458 leucine zipper and CTNNBIP1 domain containing GO:0008013,GO:0010212 beta-catenin binding|response to ionizing radiation LZTFL1 173.360696802752 195.015941011142 151.705452594362 0.777913086529139 -0.362319117873589 0.132167411212557 1 1.30884 1.32875 1.20329 0.891114 GeneID:54585,Genbank:NM_001276379.1,HGNC:HGNC:6741,MIM:606568 leucine zipper transcription factor like 1 GO:0005829,GO:0032403,GO:0042802,GO:1903565,GO:1903568 cytosol|protein complex binding|identical protein binding|negative regulation of protein localization to cilium|negative regulation of protein localization to ciliary membrane LZTR1 842.021112365844 794.795332068613 889.246892663074 1.1188375884753 0.162000628533437 0.312985137865025 1 7.07866 7.32878 8.05765 8.49457 GeneID:8216,Genbank:NM_006767.3,HGNC:HGNC:6742,MIM:600574 leucine zipper like transcription regulator 1 GO:0003700,GO:0005794,GO:0009653 DNA binding transcription factor activity|Golgi apparatus|anatomical structure morphogenesis LZTS1 608.984954069207 506.032691460415 711.937216678 1.40689965034343 0.492519429416732 0.00325817054291361 0.215249843114831 2.19987 2.17535 3.26 2.98397 GeneID:11178,Genbank:XM_005273394.3,HGNC:HGNC:13861,MIM:606551 leucine zipper tumor suppressor 1 LZTS2 1248.72257990175 1247.67979805442 1249.76536174908 1.00167155362931 0.0024095288637922 0.995079395643597 1 18.9975 18.0155 17.7809 20.1439 GeneID:84445,Genbank:XM_017016781.1,HGNC:HGNC:29381,MIM:610454 leucine zipper tumor suppressor 2 GO:0001822,GO:0005815,GO:0005829,GO:0005874,GO:0005886,GO:0007049,GO:0008285,GO:0016055,GO:0031982,GO:0051301,GO:0090090,GO:1900181 kidney development|microtubule organizing center|cytosol|microtubule|plasma membrane|cell cycle|negative regulation of cell proliferation|Wnt signaling pathway|vesicle|cell division|negative regulation of canonical Wnt signaling pathway|negative regulation of protein localization to nucleus LZTS3 287.289307193678 248.404297859171 326.174316528185 1.31307839413111 0.392953051377771 0.0558361447554108 0.857612445291018 1.70832 1.92141 2.70811 2.23401 GeneID:9762,Genbank:XM_011529407.2,HGNC:HGNC:30139,MIM:610484 leucine zipper tumor suppressor family member 3 GO:0005737,GO:0005856,GO:0014069,GO:0030054,GO:0045202,GO:0045211,GO:0061001 cytoplasm|cytoskeleton|postsynaptic density|cell junction|synapse|postsynaptic membrane|regulation of dendritic spine morphogenesis M6PR 2754.49861983326 2674.79809646098 2834.19914320553 1.05959367436199 0.0835111361419622 0.539995421858552 1 37.1207 36.6832 42.1404 37.8117 GeneID:4074,Genbank:NM_001207024.1,HGNC:HGNC:6752,MIM:154540 mannose-6-phosphate receptor, cation dependent GO:0004888,GO:0005537,GO:0005765,GO:0005768,GO:0005770,GO:0005802,GO:0005886,GO:0005887,GO:0006898,GO:0008333,GO:0015578,GO:0016020,GO:0030133,GO:0030665,GO:0032588,GO:0033299,GO:0048471,GO:0061024,GO:1905394 transmembrane signaling receptor activity|mannose binding|lysosomal membrane|endosome|late endosome|trans-Golgi network|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|endosome to lysosome transport|mannose transmembrane transporter activity|membrane|transport vesicle|clathrin-coated vesicle membrane|trans-Golgi network membrane|secretion of lysosomal enzymes|perinuclear region of cytoplasm|membrane organization|retromer complex binding hsa04142,hsa04145 Lysosome|Phagosome MAB21L1 43.9004541160636 46.6136011148875 41.1873071172396 0.883589899345604 -0.178551168099219 0.694928555520868 1 0.71663 0.778377 0.564911 0.754566 GeneID:4081,Genbank:NM_005584.4,HGNC:HGNC:6757,MIM:601280 mab-21 like 1 GO:0005524,GO:0005525,GO:0005634,GO:0008284,GO:0009653,GO:0016779,GO:0043010,GO:0046872 ATP binding|GTP binding|nucleus|positive regulation of cell proliferation|anatomical structure morphogenesis|nucleotidyltransferase activity|camera-type eye development|metal ion binding MACF1 5330.92863332621 5239.10859641748 5422.74867023493 1.03505177845388 0.0497029403334524 0.884160565420169 1 5.24374 5.07749 6.92304 3.9838 GeneID:23499,Genbank:NM_012090.5,HGNC:HGNC:13664,MIM:608271 microtubule-actin crosslinking factor 1 GO:0001707,GO:0003723,GO:0003779,GO:0005509,GO:0005737,GO:0005794,GO:0005874,GO:0005886,GO:0006620,GO:0007163,GO:0008017,GO:0010632,GO:0014069,GO:0015629,GO:0015630,GO:0016020,GO:0016055,GO:0016887,GO:0030177,GO:0030334,GO:0032587,GO:0032886,GO:0042060,GO:0043001,GO:0045296,GO:0045773,GO:0051011,GO:0051015,GO:0051893 mesoderm formation|RNA binding|actin binding|calcium ion binding|cytoplasm|Golgi apparatus|microtubule|plasma membrane|posttranslational protein targeting to endoplasmic reticulum membrane|establishment or maintenance of cell polarity|microtubule binding|regulation of epithelial cell migration|postsynaptic density|actin cytoskeleton|microtubule cytoskeleton|membrane|Wnt signaling pathway|ATPase activity|positive regulation of Wnt signaling pathway|regulation of cell migration|ruffle membrane|regulation of microtubule-based process|wound healing|Golgi to plasma membrane protein transport|cadherin binding|positive regulation of axon extension|microtubule minus-end binding|actin filament binding|regulation of focal adhesion assembly MACO1 405.802517144974 419.060747596499 392.544286693448 0.936724064338798 -0.0943039665740107 0.618754246435945 1 3.31058 3.30825 3.19909 3.19622 GeneID:55219,Genbank:NM_018202.5,HGNC:HGNC:25572,MIM:610301 macoilin 1 GO:0005634,GO:0007420,GO:0016021,GO:0023041,GO:0030424,GO:0030867,GO:0031965,GO:0043005,GO:0044306,GO:0045202 nucleus|brain development|integral component of membrane|neuronal signal transduction|axon|rough endoplasmic reticulum membrane|nuclear membrane|neuron projection|neuron projection terminus|synapse MACROD1 219.504290622143 224.832844290532 214.175736953753 0.952599864266235 -0.0700577517517128 0.78112632968713 1 2.18198 2.11821 1.7443 2.07283 GeneID:28992,Genbank:XM_011544970.2,HGNC:HGNC:29598,MIM:610400 MACRO domain containing 1 MACROD2 5.90896947250874 8.90752912949446 2.91040981552302 0.326735930156672 -1.61380298260111 0.271050923078241 1 0.0580721 0.0349704 0.0420126 0 GeneID:140733,Genbank:NM_001351661.1,HGNC:HGNC:16126,MIM:611567 MACRO domain containing 2 GO:0005634,GO:0005730,GO:0005813,GO:0006974,GO:0007420,GO:0016798,GO:0019213,GO:0042278,GO:0051725 nucleus|nucleolus|centrosome|cellular response to DNA damage stimulus|brain development|hydrolase activity, acting on glycosyl bonds|deacetylase activity|purine nucleoside metabolic process|protein de-ADP-ribosylation MAD1L1 818.666044779785 743.723062061424 893.609027498145 1.20153464788529 0.264878251140747 0.0971375203416815 1 3.84365 4.14168 5.24669 4.90273 GeneID:8379,Genbank:NM_001304524.1,HGNC:HGNC:6762,MIM:602686 mitotic arrest deficient 1 like 1 GO:0000776,GO:0000777,GO:0000922,GO:0005635,GO:0005813,GO:0005819,GO:0005829,GO:0007062,GO:0007093,GO:0007094,GO:0042130,GO:0042802,GO:0043515,GO:0048538,GO:0051301,GO:0051315,GO:0072686,GO:0090235 kinetochore|condensed chromosome kinetochore|spindle pole|nuclear envelope|centrosome|spindle|cytosol|sister chromatid cohesion|mitotic cell cycle checkpoint|mitotic spindle assembly checkpoint|negative regulation of T cell proliferation|identical protein binding|kinetochore binding|thymus development|cell division|attachment of mitotic spindle microtubules to kinetochore|mitotic spindle|regulation of metaphase plate congression hsa04110,hsa04914,hsa05203 Cell cycle|Progesterone-mediated oocyte maturation|Viral carcinogenesis MAD2L1 1400.9796074447 1574.40520832909 1227.55400656031 0.779693817110215 -0.359020400730337 0.0149662622211095 0.509999267517637 48.5262 45.8403 38.1942 36.4822 GeneID:4085,Genbank:NM_002358.3,HGNC:HGNC:6763,MIM:601467 mitotic arrest deficient 2 like 1 hsa04110,hsa04114,hsa04914,hsa05166 Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Human T-cell leukemia virus 1 infection MAD2L1BP 931.382719566693 918.751936796792 944.013502336594 1.02749552357721 0.0391321086251775 0.810726517157375 1 27.1223 27.4304 27.3855 28.657 GeneID:9587,Genbank:NM_001003690.1,HGNC:HGNC:21059 MAD2L1 binding protein GO:0005634,GO:0005730,GO:0005737,GO:0005819,GO:0007093,GO:0007096,GO:0031965 nucleus|nucleolus|cytoplasm|spindle|mitotic cell cycle checkpoint|regulation of exit from mitosis|nuclear membrane MAD2L2 1238.67064378069 1181.98385522938 1295.357432332 1.09591804202827 0.132139910724937 0.391253906040685 1 17.8021 18.8 20.1486 20.4664 GeneID:10459,Genbank:NM_001127325.1,HGNC:HGNC:6764,MIM:604094 mitotic arrest deficient 2 like 2 hsa04110,hsa04114,hsa04914,hsa05100,hsa05131 Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation|Bacterial invasion of epithelial cells|Shigellosis MADCAM1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:8174,Genbank:NM_130760.2,HGNC:HGNC:6765,MIM:102670 mucosal vascular addressin cell adhesion molecule 1 GO:0002687,GO:0005886,GO:0006955,GO:0007155,GO:0007160,GO:0007165,GO:0007229,GO:0016020,GO:0016021,GO:0030198,GO:0034113,GO:0043113,GO:0050776,GO:0050901,GO:0098640,GO:2000403 positive regulation of leukocyte migration|plasma membrane|immune response|cell adhesion|cell-matrix adhesion|signal transduction|integrin-mediated signaling pathway|membrane|integral component of membrane|extracellular matrix organization|heterotypic cell-cell adhesion|receptor clustering|regulation of immune response|leukocyte tethering or rolling|integrin binding involved in cell-matrix adhesion|positive regulation of lymphocyte migration hsa04514,hsa04672 Cell adhesion molecules (CAMs)|Intestinal immune network for IgA production MADD 1319.53052044915 1344.63546640112 1294.42557449718 0.962659104896046 -0.0549030909460253 0.703094198718408 1 5.81569 6.11326 6.01883 5.9594 GeneID:8567,Genbank:NM_130470.2,HGNC:HGNC:6766,MIM:603584 MAP kinase activating death domain GO:0000187,GO:0005123,GO:0005737,GO:0005829,GO:0005886,GO:0007166,GO:0010803,GO:0016021,GO:0017112,GO:0030295,GO:0032483,GO:0042981,GO:0051726,GO:0097194,GO:1902041,GO:2001236 activation of MAPK activity|death receptor binding|cytoplasm|cytosol|plasma membrane|cell surface receptor signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway|integral component of membrane|Rab guanyl-nucleotide exchange factor activity|protein kinase activator activity|regulation of Rab protein signal transduction|regulation of apoptotic process|regulation of cell cycle|execution phase of apoptosis|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of extrinsic apoptotic signaling pathway MAEA 2739.81107218014 2786.1119482902 2693.51019607008 0.966763089948002 -0.0487657013923464 0.70913264102666 1 28.826 29.6333 29.0886 28.1826 GeneID:10296,Genbank:NM_001017405.2,HGNC:HGNC:13731,MIM:606801 macrophage erythroblast attacher GO:0003779,GO:0005634,GO:0005654,GO:0005819,GO:0005826,GO:0005856,GO:0005887,GO:0007010,GO:0007049,GO:0007155,GO:0007346,GO:0016363,GO:0033033,GO:0034657,GO:0042787,GO:0043161,GO:0043249,GO:0045721,GO:0048822,GO:0051301 actin binding|nucleus|nucleoplasm|spindle|actomyosin contractile ring|cytoskeleton|integral component of plasma membrane|cytoskeleton organization|cell cycle|cell adhesion|regulation of mitotic cell cycle|nuclear matrix|negative regulation of myeloid cell apoptotic process|GID complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|erythrocyte maturation|negative regulation of gluconeogenesis|enucleate erythrocyte development|cell division MAEL 13.8397015074374 15.5666150030498 12.1127880118249 0.778126009376589 -0.361924291369765 0.688214644320479 1 0.197827 0.131974 0.0511537 0.127188 GeneID:84944,Genbank:XM_017002602.1,HGNC:HGNC:25929,MIM:611368 maelstrom spermatogenic transposon silencer GO:0000122,GO:0000785,GO:0000902,GO:0001741,GO:0005634,GO:0005737,GO:0007129,GO:0007140,GO:0007275,GO:0007283,GO:0008630,GO:0009566,GO:0030154,GO:0030849,GO:0031047,GO:0033391,GO:0034587,GO:0043046,GO:0043066,GO:0043186,GO:0043565,GO:0045892,GO:0046620,GO:0048471,GO:0060964,GO:0071547 negative regulation of transcription from RNA polymerase II promoter|chromatin|cell morphogenesis|XY body|nucleus|cytoplasm|synapsis|male meiotic nuclear division|multicellular organism development|spermatogenesis|intrinsic apoptotic signaling pathway in response to DNA damage|fertilization|cell differentiation|autosome|gene silencing by RNA|chromatoid body|piRNA metabolic process|DNA methylation involved in gamete generation|negative regulation of apoptotic process|P granule|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|regulation of organ growth|perinuclear region of cytoplasm|regulation of gene silencing by miRNA|piP-body MAF 166.00581989083 152.697312654285 179.314327127374 1.1743122652941 0.231816091317189 0.328341954747938 1 0.207586 0.156966 0.218145 0.213971 GeneID:4094,Genbank:XM_024450279.1,HGNC:HGNC:6776,MIM:177075 MAF bZIP transcription factor hsa04658,hsa05202,hsa05321 Th1 and Th2 cell differentiation|Transcriptional misregulation in cancer|Inflammatory bowel disease (IBD) MAF1 2039.78581296033 2000.12707580086 2079.4445501198 1.03965621748667 0.056106552097438 0.691890795109493 1 37.9927 36.2837 39.4122 40.9287 GeneID:84232,Genbank:NM_032272.4,HGNC:HGNC:24966,MIM:610210 MAF1 homolog, negative regulator of RNA polymerase III GO:0000994,GO:0001030,GO:0001031,GO:0001032,GO:0005622,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0016480,GO:0030424,GO:0030425,GO:0043231,GO:0048471,GO:0050811,GO:0060077 RNA polymerase III core binding|RNA polymerase III type 1 promoter DNA binding|RNA polymerase III type 2 promoter DNA binding|RNA polymerase III type 3 promoter DNA binding|intracellular|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|negative regulation of transcription from RNA polymerase III promoter|axon|dendrite|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|GABA receptor binding|inhibitory synapse MAFA 11.278958390127 11.8959838159236 10.6619329643304 0.896263237182507 -0.158005573316579 0.918833809278592 1 0.445965 0.2575 0.344741 0.322729 GeneID:389692,Genbank:NM_201589.3,HGNC:HGNC:23145,MIM:610303 MAF bZIP transcription factor A hsa04930,hsa04950 Type II diabetes mellitus|Maturity onset diabetes of the young MAFB 32.9319946950463 18.3629645907392 47.5010247993534 2.58678409821196 1.37115964681849 0.00679916574808687 0.326034247369339 0.257185 0.316165 0.904379 0.607795 GeneID:9935,Genbank:NM_005461.4,HGNC:HGNC:6408,MIM:608968 MAF bZIP transcription factor B GO:0000978,GO:0001077,GO:0005634,GO:0005667,GO:0006355,GO:0007379,GO:0007399,GO:0007423,GO:0007585,GO:0008134,GO:0021571,GO:0021572,GO:0021599,GO:0033077,GO:0035284,GO:0042472,GO:0042803,GO:0045647,GO:0045671,GO:0046982,GO:0048538 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|transcription factor complex|regulation of transcription, DNA-templated|segment specification|nervous system development|sensory organ development|respiratory gaseous exchange|transcription factor binding|rhombomere 5 development|rhombomere 6 development|abducens nerve formation|T cell differentiation in thymus|brain segmentation|inner ear morphogenesis|protein homodimerization activity|negative regulation of erythrocyte differentiation|negative regulation of osteoclast differentiation|protein heterodimerization activity|thymus development hsa04928 Parathyroid hormone synthesis, secretion and action MAFF 257.271952691598 283.861926588625 230.681978794571 0.812655580714342 -0.299284055350641 0.144452985151989 1 4.46246 5.11699 3.91358 3.66754 GeneID:23764,Genbank:NM_001161572.1,HGNC:HGNC:6780,MIM:604877 MAF bZIP transcription factor F GO:0001228,GO:0001701,GO:0005634,GO:0005654,GO:0005739,GO:0006366,GO:0007567,GO:0007596,GO:0035914,GO:0043565,GO:0045604,GO:0045944 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|in utero embryonic development|nucleus|nucleoplasm|mitochondrion|transcription from RNA polymerase II promoter|parturition|blood coagulation|skeletal muscle cell differentiation|sequence-specific DNA binding|regulation of epidermal cell differentiation|positive regulation of transcription from RNA polymerase II promoter MAFG 1623.60651156053 1544.75403518568 1702.45898793539 1.10209065596048 0.14024290224413 0.33480181887797 1 15.792 16.1609 17.7003 17.8862 GeneID:4097,Genbank:NM_002359.3,HGNC:HGNC:6781,MIM:602020 MAF bZIP transcription factor G GO:0000978,GO:0001077,GO:0001701,GO:0003700,GO:0005654,GO:0007596,GO:0030534,GO:0030641,GO:0042127,GO:0045604,GO:0046982 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|in utero embryonic development|DNA binding transcription factor activity|nucleoplasm|blood coagulation|adult behavior|regulation of cellular pH|regulation of cell proliferation|regulation of epidermal cell differentiation|protein heterodimerization activity MAFK 1280.88417135847 1285.30943480066 1276.45890791628 0.993114088604074 -0.00996863130426207 0.935489618164546 1 17.6011 17.8362 17.4419 18.2364 GeneID:7975,Genbank:NM_002360.3,HGNC:HGNC:6782,MIM:600197 MAF bZIP transcription factor K GO:0000122,GO:0000976,GO:0001221,GO:0001227,GO:0003700,GO:0005654,GO:0006351,GO:0007399,GO:0007596,GO:0043565,GO:0071535 negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|transcription cofactor binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|nervous system development|blood coagulation|sequence-specific DNA binding|RING-like zinc finger domain binding MAGEA1 0.807146514963456 1.61429302992691 0 0 -Inf 0.549240155942477 1 0.0866713 0 0 0 GeneID:4100,Genbank:NM_004988.4,HGNC:HGNC:6796,MIM:300016 MAGE family member A1 GO:0000122,GO:0005634,GO:0005737,GO:0005886,GO:0006351,GO:0042826,GO:0045746 negative regulation of transcription from RNA polymerase II promoter|nucleus|cytoplasm|plasma membrane|transcription, DNA-templated|histone deacetylase binding|negative regulation of Notch signaling pathway MAGEA12 19.4530086827812 22.4276146304529 16.4784027351094 0.734737198165272 -0.444699777865978 0.498547419232318 1 0.297225 0.470436 0.364874 0.320983 GeneID:4111,Genbank:NM_001166387.3,HGNC:HGNC:6799,MIM:300177 MAGE family member A12 MAGEA2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.016556 GeneID:4101,Genbank:XM_017029519.1,HGNC:HGNC:6800,MIM:300173 MAGE family member A2 GO:0000122,GO:0005634,GO:0006351,GO:0016605,GO:0031625,GO:0033234,GO:0042826,GO:0044257,GO:0051443,GO:0070491,GO:0072331,GO:0090398,GO:1901984 negative regulation of transcription from RNA polymerase II promoter|nucleus|transcription, DNA-templated|PML body|ubiquitin protein ligase binding|negative regulation of protein sumoylation|histone deacetylase binding|cellular protein catabolic process|positive regulation of ubiquitin-protein transferase activity|repressing transcription factor binding|signal transduction by p53 class mediator|cellular senescence|negative regulation of protein acetylation MAGEA3 889.309855100245 923.268440618886 855.351269581603 0.92643832708962 -0.110233155508466 0.469997902617144 1 12.8277 12.897 12.109 12.1215 GeneID:4102,Genbank:XM_005274676.3,HGNC:HGNC:6801,MIM:300174 MAGE family member A3 GO:0005783,GO:0010955,GO:0043154,GO:0089720,GO:1902236 endoplasmic reticulum|negative regulation of protein processing|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|caspase binding|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway MAGEA4 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0216148 0.0225775 0 GeneID:4103,Genbank:NM_001011548.1,HGNC:HGNC:6802,MIM:300175 MAGE family member A4 MAGEA6 1323.63405577386 1360.62450922122 1286.6436023265 0.945627242201401 -0.0806564967421174 0.583343019289087 1 32.0242 31.8779 30.5569 31.1269 GeneID:4105,Genbank:NM_005363.3,HGNC:HGNC:6804,MIM:300176 MAGE family member A6 MAGEA8 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0168185 0 GeneID:4107,Genbank:NM_001166400.1,HGNC:HGNC:6806,MIM:300341 MAGE family member A8 MAGEB17 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0185623 0 0.0173781 0 GeneID:645864,Genbank:NM_001277307.1,HGNC:HGNC:17418,MIM:300763 MAGE family member B17 MAGEB18 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0.0225728 0.0459144 0 GeneID:286514,Genbank:NM_173699.3,HGNC:HGNC:28515 MAGE family member B18 GO:0005737 cytoplasm MAGEB6 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0237548 0 GeneID:158809,Genbank:NM_173523.2,HGNC:HGNC:23796,MIM:300467 MAGE family member B6 MAGEC3 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0 0.00936627 0 GeneID:139081,Genbank:NM_138702.1,HGNC:HGNC:23798,MIM:300469 MAGE family member C3 MAGED1 1767.50790604452 1611.07635358334 1923.93945850571 1.19419508220483 0.2560385326999 0.0752008341478489 0.94157495521624 13.7722 14.9174 17.7824 17.515 GeneID:9500,Genbank:XM_011530835.2,HGNC:HGNC:6813,MIM:300224 MAGE family member D1 GO:0000785,GO:0003713,GO:0005634,GO:0005737,GO:0005886,GO:0006355,GO:0006357,GO:0032922,GO:0042752,GO:0042802,GO:0042981,GO:0043234,GO:0043406,GO:0045892,GO:0045893,GO:0050680,GO:0090190,GO:2001235 chromatin|transcription coactivator activity|nucleus|cytoplasm|plasma membrane|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|circadian regulation of gene expression|regulation of circadian rhythm|identical protein binding|regulation of apoptotic process|protein complex|positive regulation of MAP kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of epithelial cell proliferation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of apoptotic signaling pathway hsa04722 Neurotrophin signaling pathway MAGED2 2487.31504373774 2385.40435662933 2589.22573084616 1.08544520917403 0.118286903799279 0.404346149527674 1 29.2527 31.5132 32.3361 34.3086 GeneID:10916,Genbank:NM_177433.2,HGNC:HGNC:16353,MIM:300470 MAGE family member D2 GO:0002576,GO:0005576,GO:0005634,GO:0005730,GO:0005829,GO:0007565,GO:0016020,GO:0031093,GO:0070294 platelet degranulation|extracellular region|nucleus|nucleolus|cytosol|female pregnancy|membrane|platelet alpha granule lumen|renal sodium ion absorption MAGED4 9.83146195817614 7.5431761281002 12.1197477882521 1.60671679706682 0.684115659272319 0.504860186589598 1 0.0301824 0.0398022 0.211276 0.0918353 GeneID:728239,Genbank:NM_001272061.1,HGNC:HGNC:23793,MIM:300702 MAGE family member D4 MAGED4B 2.94519075718418 2.49838328447175 3.3919982298966 1.35767728313704 0.441140594938075 0.922763480163738 1 0 0.0398022 0.0140851 0.0262387 GeneID:81557,Genbank:NM_177535.2,HGNC:HGNC:22880,MIM:300765 MAGE family member D4B MAGEE1 15.9925367946921 18.4109908654241 13.5740827239602 0.737281487084563 -0.439712563099534 0.555922976069767 1 0.202513 0.227141 0.225844 0.0998884 GeneID:57692,Genbank:NM_020932.2,HGNC:HGNC:24934,MIM:300759 MAGE family member E1 GO:0005634,GO:0005886,GO:0016010,GO:0030425,GO:0045211,GO:0048471 nucleus|plasma membrane|dystrophin-associated glycoprotein complex|dendrite|postsynaptic membrane|perinuclear region of cytoplasm MAGEF1 2371.47733210628 2170.52275985369 2572.43190435888 1.18516698001926 0.245090336992267 0.0736494656088307 0.934750619674839 65.1374 59.8734 77.9121 72.7788 GeneID:64110,Genbank:NM_022149.4,HGNC:HGNC:29639,MIM:609267 MAGE family member F1 GO:0070062 extracellular exosome MAGEH1 177.537256786349 175.768886165858 179.30562740684 1.0201215432272 0.0287410535346291 0.906753709971085 1 6.07073 5.67287 5.95622 6.19612 GeneID:28986,Genbank:NM_014061.4,HGNC:HGNC:24092,MIM:300548 MAGE family member H1 GO:0005737,GO:0006915 cytoplasm|apoptotic process MAGI1 366.906245341035 383.862867550686 349.949623131384 0.911652709115386 -0.133443755430009 0.504866252144567 1 1.32525 1.36364 1.39821 0.999259 GeneID:9223,Genbank:NM_001033057.1,HGNC:HGNC:946,MIM:602625 membrane associated guanylate kinase, WW and PDZ domain containing 1 GO:0005524,GO:0005654,GO:0005737,GO:0005886,GO:0005911,GO:0005912,GO:0005923,GO:0006461,GO:0007155,GO:0007166,GO:0008022,GO:0030054,GO:0032947,GO:0042995,GO:0051393,GO:0070997 ATP binding|nucleoplasm|cytoplasm|plasma membrane|cell-cell junction|adherens junction|bicellular tight junction|protein complex assembly|cell adhesion|cell surface receptor signaling pathway|protein C-terminus binding|cell junction|protein complex scaffold activity|cell projection|alpha-actinin binding|neuron death hsa04015,hsa04151,hsa04530,hsa05165 Rap1 signaling pathway|PI3K-Akt signaling pathway|Tight junction|Human papillomavirus infection MAGI2 112.391787950097 86.1740975036322 138.609478396562 1.60848192684257 0.685699725731974 0.0159223230473134 0.52579778541396 0.0977979 0.101839 0.162573 0.133012 GeneID:9863,Genbank:XM_017012845.2,HGNC:HGNC:18957,MIM:606382 membrane associated guanylate kinase, WW and PDZ domain containing 2 GO:0002092,GO:0003402,GO:0004871,GO:0005634,GO:0005737,GO:0005770,GO:0005886,GO:0005923,GO:0008285,GO:0010976,GO:0014069,GO:0019902,GO:0030159,GO:0030336,GO:0030425,GO:0031697,GO:0032516,GO:0032926,GO:0036057,GO:0038180,GO:0043113,GO:0043234,GO:0045202,GO:0046332,GO:0048471,GO:0051291,GO:0051898,GO:0060395,GO:0070699,GO:0071850,GO:0072015,GO:0097118,GO:1990090,GO:2000809 positive regulation of receptor internalization|planar cell polarity pathway involved in axis elongation|signal transducer activity|nucleus|cytoplasm|late endosome|plasma membrane|bicellular tight junction|negative regulation of cell proliferation|positive regulation of neuron projection development|postsynaptic density|phosphatase binding|receptor signaling complex scaffold activity|negative regulation of cell migration|dendrite|beta-1 adrenergic receptor binding|positive regulation of phosphoprotein phosphatase activity|negative regulation of activin receptor signaling pathway|slit diaphragm|nerve growth factor signaling pathway|receptor clustering|protein complex|synapse|SMAD binding|perinuclear region of cytoplasm|protein heterooligomerization|negative regulation of protein kinase B signaling|SMAD protein signal transduction|type II activin receptor binding|mitotic cell cycle arrest|glomerular visceral epithelial cell development|neuroligin clustering involved in postsynaptic membrane assembly|cellular response to nerve growth factor stimulus|positive regulation of synaptic vesicle clustering hsa04015,hsa04151 Rap1 signaling pathway|PI3K-Akt signaling pathway MAGI3 346.909766948878 331.723193844466 362.096340053291 1.09156172004984 0.126393706776159 0.744080849617568 1 1.3021 1.02882 1.68534 0.92457 GeneID:260425,Genbank:XM_011541208.2,HGNC:HGNC:29647,MIM:615943 membrane associated guanylate kinase, WW and PDZ domain containing 3 GO:0004385,GO:0005524,GO:0005634,GO:0005886,GO:0005923,GO:0006915,GO:0016020,GO:0016032,GO:0030054,GO:0032947,GO:0035556,GO:0046328 guanylate kinase activity|ATP binding|nucleus|plasma membrane|bicellular tight junction|apoptotic process|membrane|viral process|cell junction|protein complex scaffold activity|intracellular signal transduction|regulation of JNK cascade hsa04015 Rap1 signaling pathway MAGIX 29.3417190079506 28.1545839747785 30.5288540411228 1.084329786882 0.116803603130877 0.859655170699465 1 0.259786 0.294084 0.255543 0.30517 GeneID:79917,Genbank:XM_011543985.2,HGNC:HGNC:30006 MAGI family member, X-linked MAGOH 825.538974546735 887.339340796836 763.738608296633 0.860706353457507 -0.216406976509486 0.171251741642771 1 39.496 39.6413 34.3752 36.4298 GeneID:4116,Genbank:NM_002370.3,HGNC:HGNC:6815,MIM:602603 mago homolog, exon junction complex core component GO:0000184,GO:0000381,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0006369,GO:0006405,GO:0006406,GO:0006417,GO:0016607,GO:0031124,GO:0035145,GO:0071013 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|cytoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|regulation of translation|nuclear speck|mRNA 3'-end processing|exon-exon junction complex|catalytic step 2 spliceosome hsa03013,hsa03015,hsa03040 RNA transport|mRNA surveillance pathway|Spliceosome MAGOHB 449.01356779239 477.388036083679 420.639099501101 0.881126186051653 -0.182579452637492 0.307863748513377 1 3.82366 4.0982 3.53872 3.65483 GeneID:55110,Genbank:NM_001319985.1,HGNC:HGNC:25504 mago homolog B, exon junction complex core component GO:0003723,GO:0006397,GO:0008380,GO:0035145,GO:0051028,GO:0071013 RNA binding|mRNA processing|RNA splicing|exon-exon junction complex|mRNA transport|catalytic step 2 spliceosome hsa03013,hsa03015,hsa03040 RNA transport|mRNA surveillance pathway|Spliceosome MAGT1 2025.19908188598 2136.58337160479 1913.81479216717 0.895736069840185 -0.158854392542619 0.268157583447436 1 23.8146 22.5878 21.7686 20.0083 GeneID:84061,Genbank:NM_032121.5,HGNC:HGNC:28880,MIM:300715 magnesium transporter 1 GO:0005783,GO:0005886,GO:0005887,GO:0006487,GO:0008250,GO:0015095,GO:0015693,GO:0016020,GO:0018279,GO:0035577,GO:0043312,GO:0050890,GO:0055085 endoplasmic reticulum|plasma membrane|integral component of plasma membrane|protein N-linked glycosylation|oligosaccharyltransferase complex|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|protein N-linked glycosylation via asparagine|azurophil granule membrane|neutrophil degranulation|cognition|transmembrane transport MAIP1 344.385438494627 359.705290030721 329.065586958533 0.914819982020364 -0.128440216624829 0.523481211770294 1 12.2659 11.1556 10.5747 10.7094 GeneID:79568,Genbank:NM_024520.2,HGNC:HGNC:26198,MIM:617267 matrix AAA peptidase interacting protein 1 GO:0005743,GO:0005759,GO:0006851,GO:0007007,GO:0032979,GO:0036444,GO:0043022,GO:0051204,GO:0051560,GO:0097033,GO:0097034 mitochondrial inner membrane|mitochondrial matrix|mitochondrial calcium ion transmembrane transport|inner mitochondrial membrane organization|protein insertion into mitochondrial membrane from inner side|mitochondrial calcium uptake|ribosome binding|protein insertion into mitochondrial membrane|mitochondrial calcium ion homeostasis|mitochondrial respiratory chain complex III biogenesis|mitochondrial respiratory chain complex IV biogenesis MAK 8.02939450045869 6.85119097229513 9.20759802862226 1.343941230927 0.426470052027428 0.697572191808969 1 0.022452 0.0106333 0.0161131 0.0100084 GeneID:4117,Genbank:XM_017010865.1,HGNC:HGNC:6816,MIM:154235 male germ cell associated kinase GO:0001750,GO:0001917,GO:0003713,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005929,GO:0006351,GO:0006355,GO:0006468,GO:0007275,GO:0007283,GO:0010468,GO:0030154,GO:0030496,GO:0035556,GO:0042073,GO:0045494,GO:0046777,GO:0046872,GO:0060271,GO:0072686 photoreceptor outer segment|photoreceptor inner segment|transcription coactivator activity|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|centrosome|cilium|transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|multicellular organism development|spermatogenesis|regulation of gene expression|cell differentiation|midbody|intracellular signal transduction|intraciliary transport|photoreceptor cell maintenance|protein autophosphorylation|metal ion binding|cilium assembly|mitotic spindle MAK16 652.186408556937 735.389814226439 568.983002887435 0.773716186817126 -0.370123638285409 0.0637033006554478 0.897898872552551 7.71428 6.35264 6.0006 4.96798 GeneID:84549,Genbank:NM_032509.3,HGNC:HGNC:13703 MAK16 homolog GO:0000460,GO:0000470,GO:0003723,GO:0005730,GO:0030687,GO:0043231 maturation of 5.8S rRNA|maturation of LSU-rRNA|RNA binding|nucleolus|preribosome, large subunit precursor|intracellular membrane-bounded organelle MAL 1.29177983152393 1.61429302992691 0.969266633120943 0.600427936658332 -0.735936990778882 0.974657200381333 1 0.156881 0 0.049116 0.0457853 GeneID:4118,Genbank:NM_002371.3,HGNC:HGNC:6817,MIM:188860 mal, T cell differentiation protein MALL 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0 0 0 0.0135351 GeneID:7851,Genbank:XM_011511809.1,HGNC:HGNC:6818,MIM:602022 mal, T cell differentiation protein like GO:0000139,GO:0001766,GO:0005886,GO:0008104,GO:0016021,GO:0019911,GO:0030136,GO:0031410,GO:0042552,GO:0042632,GO:0045121 Golgi membrane|membrane raft polarization|plasma membrane|protein localization|integral component of membrane|structural constituent of myelin sheath|clathrin-coated vesicle|cytoplasmic vesicle|myelination|cholesterol homeostasis|membrane raft MALSU1 829.836415524066 845.040329750195 814.632501297937 0.964016121619607 -0.0528708214755116 0.741930275351052 1 31.9795 31.3928 30.072 30.7795 GeneID:115416,Genbank:XM_017011731.1,HGNC:HGNC:21721,MIM:614624 mitochondrial assembly of ribosomal large subunit 1 GO:0005739,GO:0005759,GO:0005829,GO:0042273,GO:0043023,GO:0070130,GO:0090071 mitochondrion|mitochondrial matrix|cytosol|ribosomal large subunit biogenesis|ribosomal large subunit binding|negative regulation of mitochondrial translation|negative regulation of ribosome biogenesis MALT1 1853.61993853558 1829.92923749845 1877.3106395727 1.02589247775451 0.0368795321739005 0.892175827857438 1 12.9169 12.1977 16.462 10.1457 GeneID:10892,Genbank:NM_006785.3,HGNC:HGNC:6819,MIM:604860 MALT1 paracaspase hsa04064,hsa04625,hsa04660,hsa04662,hsa05152 NF-kappa B signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway|Tuberculosis MAMDC2 198.97590851617 189.567320659818 208.384496372522 1.09926381639624 0.136537665569507 0.538327965445855 1 1.45681 1.31387 1.40254 1.57709 GeneID:256691,Genbank:NM_153267.4,HGNC:HGNC:23673,MIM:612879 MAM domain containing 2 GO:0005578,GO:0005783,GO:0016020 proteinaceous extracellular matrix|endoplasmic reticulum|membrane MAMDC4 23.7062566005051 19.295081119969 28.1174320810413 1.45723316249455 0.543231732215048 0.448268680762172 1 0.16436 0.175694 0.191497 0.0770576 GeneID:158056,Genbank:NM_206920.2,HGNC:HGNC:24083,MIM:617208 MAM domain containing 4 GO:0015031,GO:0016021 protein transport|integral component of membrane MAML1 1574.49080635063 1613.61193748653 1535.36967521472 0.951511103472818 -0.0717076030420794 0.618760797015735 1 11.5746 11.6136 12.0115 10.4237 GeneID:9794,Genbank:NM_014757.4,HGNC:HGNC:13632,MIM:605424 mastermind like transcriptional coactivator 1 GO:0002193,GO:0003162,GO:0003713,GO:0005634,GO:0005654,GO:0006367,GO:0006468,GO:0007219,GO:0007221,GO:0010831,GO:0016607,GO:0019901,GO:0042605,GO:0043231,GO:0045445,GO:0045747,GO:0045944,GO:0060928 MAML1-RBP-Jkappa- ICN1 complex|atrioventricular node development|transcription coactivator activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|protein phosphorylation|Notch signaling pathway|positive regulation of transcription of Notch receptor target|positive regulation of myotube differentiation|nuclear speck|protein kinase binding|peptide antigen binding|intracellular membrane-bounded organelle|myoblast differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|atrioventricular node cell development hsa04330,hsa04658,hsa05165 Notch signaling pathway|Th1 and Th2 cell differentiation|Human papillomavirus infection MAML2 420.3153489314 393.730922173879 446.89977568892 1.13503855176394 0.182741299713631 0.505905093688628 1 1.33942 1.24786 1.79394 1.18169 GeneID:84441,Genbank:NM_032427.3,HGNC:HGNC:16259,MIM:607537 mastermind like transcriptional coactivator 2 hsa04330,hsa04658,hsa05165 Notch signaling pathway|Th1 and Th2 cell differentiation|Human papillomavirus infection MAML3 132.9019123003 126.704928041184 139.098896559416 1.09781757276405 0.134638337827043 0.605810536552035 1 0.725842 0.575896 0.807395 0.667107 GeneID:55534,Genbank:NM_018717.4,HGNC:HGNC:16272,MIM:608991 mastermind like transcriptional coactivator 3 GO:0003713,GO:0005634,GO:0005654,GO:0006367,GO:0007219,GO:0007221,GO:0016607,GO:0045747,GO:0045944 transcription coactivator activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|positive regulation of transcription of Notch receptor target|nuclear speck|positive regulation of Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter hsa04330,hsa04658,hsa05165 Notch signaling pathway|Th1 and Th2 cell differentiation|Human papillomavirus infection MAMLD1 388.479012906468 398.411122130244 378.546903682692 0.95014140583892 -0.0737858547899477 0.718600284263112 1 3.20407 3.16217 3.59039 2.46788 GeneID:10046,Genbank:XM_017029189.2,HGNC:HGNC:2568,MIM:300120 mastermind like domain containing 1 GO:0005654,GO:0005794,GO:0005813,GO:0006351,GO:0006355,GO:0008584,GO:0016604 nucleoplasm|Golgi apparatus|centrosome|transcription, DNA-templated|regulation of transcription, DNA-templated|male gonad development|nuclear body MAMSTR 44.3976891212035 41.7707220251068 47.0246562173002 1.12578030585719 0.170925315362519 0.808879818756902 1 0.448724 0.518653 0.743357 0.271782 GeneID:284358,Genbank:XM_024451463.1,HGNC:HGNC:26689,MIM:610349 MEF2 activating motif and SAP domain containing transcriptional regulator GO:0001076,GO:0005634,GO:0006351,GO:0010831,GO:0045944 transcription factor activity, RNA polymerase II transcription factor binding|nucleus|transcription, DNA-templated|positive regulation of myotube differentiation|positive regulation of transcription from RNA polymerase II promoter MAN1A1 983.522637584848 1028.17787025392 938.867404915776 0.913137144922126 -0.131096538686595 0.628888601002857 1 7.89621 7.0713 8.25987 5.65935 GeneID:4121,Genbank:NM_005907.3,HGNC:HGNC:6821,MIM:604344 mannosidase alpha class 1A member 1 GO:0000139,GO:0004571,GO:0005509,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0006486,GO:0006491,GO:0015923,GO:0016020,GO:0016021,GO:0070062,GO:1904381 Golgi membrane|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|protein glycosylation|N-glycan processing|mannosidase activity|membrane|integral component of membrane|extracellular exosome|Golgi apparatus mannose trimming hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum MAN1A2 775.123331704476 758.749545386122 791.49711802283 1.04315992389826 0.0609603503106203 0.780262805363785 1 2.30234 2.02917 2.66959 1.87185 GeneID:10905,Genbank:XM_011540536.3,HGNC:HGNC:6822,MIM:604345 mannosidase alpha class 1A member 2 GO:0000139,GO:0004571,GO:0005509,GO:0005783,GO:0005794,GO:0006486,GO:0006491,GO:0007585,GO:0016020,GO:0016021,GO:0048286,GO:0070062,GO:1904381 Golgi membrane|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|Golgi apparatus|protein glycosylation|N-glycan processing|respiratory gaseous exchange|membrane|integral component of membrane|lung alveolus development|extracellular exosome|Golgi apparatus mannose trimming hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum MAN1B1 2846.44468833586 2559.82850710401 3133.06086956771 1.2239338927873 0.291525637178015 0.0352669728888744 0.734506941207039 21.1968 22.3014 27.0153 27.315 GeneID:11253,Genbank:NM_016219.4,HGNC:HGNC:6823,MIM:604346 mannosidase alpha class 1B member 1 GO:0000139,GO:0004571,GO:0005509,GO:0005783,GO:0005789,GO:0005794,GO:0006486,GO:0006491,GO:0009311,GO:0016020,GO:0016021,GO:0030433,GO:0036508,GO:0036509,GO:0036510,GO:0036511,GO:0036512,GO:0044322,GO:1903561,GO:1904380,GO:1904382 Golgi membrane|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein glycosylation|N-glycan processing|oligosaccharide metabolic process|membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|protein alpha-1,2-demannosylation|trimming of terminal mannose on B branch|trimming of terminal mannose on C branch|trimming of first mannose on A branch|trimming of second mannose on A branch|endoplasmic reticulum quality control compartment|extracellular vesicle|endoplasmic reticulum mannose trimming|mannose trimming involved in glycoprotein ERAD pathway hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum MAN1C1 33.5103483259214 33.103324269037 33.9173723828058 1.02459112888944 0.0350483058231133 0.994559200532428 1 0.173958 0.246556 0.19233 0.249139 GeneID:57134,Genbank:XM_017001861.1,HGNC:HGNC:19080,MIM:616772 mannosidase alpha class 1C member 1 GO:0000139,GO:0004571,GO:0005509,GO:0005783,GO:0006487,GO:0006491,GO:0030173,GO:0070062,GO:1904381 Golgi membrane|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|protein N-linked glycosylation|N-glycan processing|integral component of Golgi membrane|extracellular exosome|Golgi apparatus mannose trimming hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum MAN2A1 768.162104016346 752.532504639839 783.791703392853 1.04153866917413 0.0587164032673 0.844188983589419 1 4.61714 3.91385 5.57723 3.43168 GeneID:4124,Genbank:NM_002372.3,HGNC:HGNC:6824,MIM:154582 mannosidase alpha class 2A member 1 GO:0000139,GO:0001701,GO:0001889,GO:0004559,GO:0004572,GO:0005797,GO:0005801,GO:0006013,GO:0006486,GO:0006491,GO:0006517,GO:0007005,GO:0007033,GO:0007585,GO:0016020,GO:0016021,GO:0016799,GO:0030246,GO:0046872,GO:0048286,GO:0050769,GO:0060042,GO:0070062 Golgi membrane|in utero embryonic development|liver development|alpha-mannosidase activity|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|Golgi medial cisterna|cis-Golgi network|mannose metabolic process|protein glycosylation|N-glycan processing|protein deglycosylation|mitochondrion organization|vacuole organization|respiratory gaseous exchange|membrane|integral component of membrane|hydrolase activity, hydrolyzing N-glycosyl compounds|carbohydrate binding|metal ion binding|lung alveolus development|positive regulation of neurogenesis|retina morphogenesis in camera-type eye|extracellular exosome hsa00510 N-Glycan biosynthesis MAN2A2 2368.2060274012 2350.12023268925 2386.29182211314 1.01539137824557 0.0220359152144788 0.896336329953011 1 11.3639 12.6609 12.6854 12.3277 GeneID:4122,Genbank:NM_001320977.1,HGNC:HGNC:6825,MIM:600988 mannosidase alpha class 2A member 2 GO:0000139,GO:0004559,GO:0004572,GO:0006013,GO:0006486,GO:0006491,GO:0006517,GO:0016021,GO:0016799,GO:0030246,GO:0046872 Golgi membrane|alpha-mannosidase activity|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|mannose metabolic process|protein glycosylation|N-glycan processing|protein deglycosylation|integral component of membrane|hydrolase activity, hydrolyzing N-glycosyl compounds|carbohydrate binding|metal ion binding hsa00510 N-Glycan biosynthesis MAN2B1 2285.92909753235 2143.51506581966 2428.34312924504 1.1328789650081 0.179993734141539 0.202706537956982 1 21.8089 22.3855 25.2206 27.4221 GeneID:4125,Genbank:NM_001173498.1,HGNC:HGNC:6826,MIM:609458 mannosidase alpha class 2B member 1 hsa00511,hsa04142 Other glycan degradation|Lysosome MAN2B2 1579.10309355208 1543.4671344243 1614.73905267986 1.04617650526271 0.0651262758534734 0.669674555781835 1 13.0068 13.8738 14.2557 14.3893 GeneID:23324,Genbank:NM_015274.2,HGNC:HGNC:29623 mannosidase alpha class 2B member 2 GO:0004559,GO:0006013,GO:0006517,GO:0008496,GO:0009313,GO:0030246,GO:0043202,GO:0046872,GO:0070062 alpha-mannosidase activity|mannose metabolic process|protein deglycosylation|mannan endo-1,6-alpha-mannosidase activity|oligosaccharide catabolic process|carbohydrate binding|lysosomal lumen|metal ion binding|extracellular exosome hsa00511 Other glycan degradation MAN2C1 652.833831747715 648.525765568712 657.141897926718 1.01328572096199 0.0190410350406573 0.922382092140008 1 5.09366 5.01032 4.83734 5.15206 GeneID:4123,Genbank:XM_017022187.1,HGNC:HGNC:6827,MIM:154580 mannosidase alpha class 2C member 1 GO:0004559,GO:0005654,GO:0005773,GO:0005829,GO:0006013,GO:0006517,GO:0009313,GO:0030246,GO:0046872 alpha-mannosidase activity|nucleoplasm|vacuole|cytosol|mannose metabolic process|protein deglycosylation|oligosaccharide catabolic process|carbohydrate binding|metal ion binding hsa00511 Other glycan degradation MANBA 361.911184829276 367.604267391831 356.218102266721 0.969026025715382 -0.045392681397368 0.822581301047202 1 1.72483 1.83101 1.88346 1.50544 GeneID:4126,Genbank:NM_005908.3,HGNC:HGNC:6831,MIM:609489 mannosidase beta GO:0004567,GO:0005537,GO:0005886,GO:0006464,GO:0009313,GO:0035577,GO:0043202,GO:0043231,GO:0043312 beta-mannosidase activity|mannose binding|plasma membrane|cellular protein modification process|oligosaccharide catabolic process|azurophil granule membrane|lysosomal lumen|intracellular membrane-bounded organelle|neutrophil degranulation hsa00511,hsa04142 Other glycan degradation|Lysosome MANBAL 1422.04678453248 1471.65899505659 1372.43457400837 0.932576485869675 -0.100706041090839 0.470435745243462 1 26.6185 30.5137 26.8307 26.998 GeneID:63905,Genbank:NM_022077.3,HGNC:HGNC:15799 mannosidase beta like GO:0016021 integral component of membrane MANEA 95.839330864081 104.911463636743 86.767198091419 0.82705164034172 -0.273950682130515 0.516290761281464 1 1.01282 0.730097 0.974491 0.534904 GeneID:79694,Genbank:NM_024641.3,HGNC:HGNC:21072,MIM:612327 mannosidase endo-alpha GO:0000139,GO:0004569,GO:0005794,GO:0016021 Golgi membrane|glycoprotein endo-alpha-1,2-mannosidase activity|Golgi apparatus|integral component of membrane MANEAL 782.631296477675 781.169385363177 784.093207592173 1.00374287866855 0.00538975217992989 0.987591533732794 1 9.42339 9.95469 9.95161 10.2268 GeneID:149175,Genbank:XM_005270510.3,HGNC:HGNC:26452 mannosidase endo-alpha like GO:0000139,GO:0016021,GO:0016798 Golgi membrane|integral component of membrane|hydrolase activity, acting on glycosyl bonds MANF 3384.37250379018 3244.58809645053 3524.15691112982 1.08616465522546 0.119242822544701 0.38205815000028 1 117.569 121.028 133.174 129.217 GeneID:7873,Genbank:NM_006010.5,HGNC:HGNC:15461,MIM:601916 mesencephalic astrocyte derived neurotrophic factor GO:0002576,GO:0003723,GO:0005576,GO:0005615,GO:0005634,GO:0005783,GO:0005829,GO:0006986,GO:0008083,GO:0031175,GO:0071542 platelet degranulation|RNA binding|extracellular region|extracellular space|nucleus|endoplasmic reticulum|cytosol|response to unfolded protein|growth factor activity|neuron projection development|dopaminergic neuron differentiation MANSC1 331.982520565108 321.836538911911 342.128502218305 1.06305052675186 0.0882101697401172 0.660033062817736 1 5.24226 5.68443 5.66549 6.08979 GeneID:54682,Genbank:XM_017019531.2,HGNC:HGNC:25505 MANSC domain containing 1 GO:0016021 integral component of membrane MANSC4 1.2374454993887 0.538097676642304 1.93679332213509 3.5993341101574 1.84773002743481 0.680703344325985 1 0.0216485 0 0 0.0773391 GeneID:100287284,Genbank:NM_001146221.2,HGNC:HGNC:40023 MANSC domain containing 4 GO:0016021 integral component of membrane MAOA 66.8106379160315 68.1953431103726 65.4259327216903 0.959390036586516 -0.0598106378806511 0.911497980822279 1 0.486121 0.334505 0.424543 0.361748 GeneID:4128,Genbank:NM_001270458.1,HGNC:HGNC:6833,MIM:309850 monoamine oxidase A hsa00260,hsa00330,hsa00340,hsa00350,hsa00360,hsa00380,hsa00982,hsa04726,hsa04728,hsa05030,hsa05031,hsa05034 Glycine, serine and threonine metabolism|Arginine and proline metabolism|Histidine metabolism|Tyrosine metabolism|Phenylalanine metabolism|Tryptophan metabolism|Drug metabolism - cytochrome P450|Serotonergic synapse|Dopaminergic synapse|Cocaine addiction|Amphetamine addiction|Alcoholism MAP10 3.90772725302294 6.36111957033777 1.45433493570811 0.228628768823927 -2.1289211426552 0.3274112356474 1 0.0799566 0.0155397 0.0154544 0.00717451 GeneID:54627,Genbank:NM_019090.2,HGNC:HGNC:29265 microtubule associated protein 10 GO:0005813,GO:0005881,GO:0008017,GO:0030496,GO:0031122,GO:0032467,GO:0032886,GO:0051256,GO:0051301,GO:0097431,GO:1990023 centrosome|cytoplasmic microtubule|microtubule binding|midbody|cytoplasmic microtubule organization|positive regulation of cytokinesis|regulation of microtubule-based process|mitotic spindle midzone assembly|cell division|mitotic spindle pole|mitotic spindle midzone MAP1A 246.745722765571 197.380054126667 296.111391404475 1.50020929275077 0.585163783754872 0.00636540893671234 0.31759622906662 0.474834 0.53542 0.79163 0.743066 GeneID:4130,Genbank:NM_002373.5,HGNC:HGNC:6835,MIM:600178 microtubule associated protein 1A GO:0000226,GO:0005198,GO:0005737,GO:0005874,GO:0005875,GO:0008017 microtubule cytoskeleton organization|structural molecule activity|cytoplasm|microtubule|microtubule associated complex|microtubule binding MAP1B 6503.82813475416 6391.03607264146 6616.62019686686 1.03529695680972 0.0500446389021357 0.878787747603384 1 16.6093 14.2978 20.5482 11.865 GeneID:4131,Genbank:NM_005909.4,HGNC:HGNC:6836,MIM:157129 microtubule associated protein 1B GO:0001578,GO:0001750,GO:0005198,GO:0005829,GO:0005874,GO:0005875,GO:0005886,GO:0008017,GO:0009987,GO:0014069,GO:0016358,GO:0030054,GO:0030424,GO:0030425,GO:0032387,GO:0036477,GO:0043025,GO:0043197,GO:0045773,GO:0047497,GO:0048675,GO:0061162,GO:0097440,GO:0097441,GO:0097457 microtubule bundle formation|photoreceptor outer segment|structural molecule activity|cytosol|microtubule|microtubule associated complex|plasma membrane|microtubule binding|cellular process|postsynaptic density|dendrite development|cell junction|axon|dendrite|negative regulation of intracellular transport|somatodendritic compartment|neuronal cell body|dendritic spine|positive regulation of axon extension|mitochondrion transport along microtubule|axon extension|establishment of monopolar cell polarity|apical dendrite|basal dendrite|hippocampal mossy fiber MAP1LC3A 407.240450792663 388.523450196835 425.957451388492 1.09634939968924 0.132707649454731 0.47627372075172 1 14.9139 15.178 15.4164 17.4118 GeneID:84557,Genbank:XM_011529084.2,HGNC:HGNC:6838,MIM:601242 microtubule associated protein 1 light chain 3 alpha GO:0000045,GO:0000421,GO:0000422,GO:0005543,GO:0005737,GO:0005770,GO:0005776,GO:0005829,GO:0005874,GO:0006995,GO:0008017,GO:0008429,GO:0009267,GO:0010040,GO:0010288,GO:0015630,GO:0016236,GO:0031090,GO:0031625,GO:0034198,GO:0043278,GO:0044754,GO:0070301,GO:0071280,GO:0097352 autophagosome assembly|autophagosome membrane|autophagy of mitochondrion|phospholipid binding|cytoplasm|late endosome|autophagosome|cytosol|microtubule|cellular response to nitrogen starvation|microtubule binding|phosphatidylethanolamine binding|cellular response to starvation|response to iron(II) ion|response to lead ion|microtubule cytoskeleton|macroautophagy|organelle membrane|ubiquitin protein ligase binding|cellular response to amino acid starvation|response to morphine|autolysosome|cellular response to hydrogen peroxide|cellular response to copper ion|autophagosome maturation hsa04216 Ferroptosis MAP1LC3B 3529.95448613457 3510.55547853845 3549.3534937307 1.01105181656562 0.0158569374848556 0.900171390727091 1 63.5571 63.4739 65.0532 64.3865 GeneID:81631,Genbank:NM_022818.4,HGNC:HGNC:13352,MIM:609604 microtubule associated protein 1 light chain 3 beta GO:0000045,GO:0000421,GO:0000422,GO:0005622,GO:0005739,GO:0005776,GO:0005829,GO:0005874,GO:0005930,GO:0006914,GO:0006995,GO:0009267,GO:0012505,GO:0016236,GO:0031090,GO:0031410,GO:0031625,GO:0097352 autophagosome assembly|autophagosome membrane|autophagy of mitochondrion|intracellular|mitochondrion|autophagosome|cytosol|microtubule|axoneme|autophagy|cellular response to nitrogen starvation|cellular response to starvation|endomembrane system|macroautophagy|organelle membrane|cytoplasmic vesicle|ubiquitin protein ligase binding|autophagosome maturation hsa04216 Ferroptosis MAP1LC3B2 132.1906223112 125.302357420212 139.078887202188 1.10994629363416 0.150489871366223 0.591430725503216 1 6.10074 6.96791 6.82772 7.45083 GeneID:643246,Genbank:NM_001085481.2,HGNC:HGNC:34390 microtubule associated protein 1 light chain 3 beta 2 GO:0000045,GO:0000421,GO:0000422,GO:0005829,GO:0005874,GO:0006995,GO:0012505,GO:0031410 autophagosome assembly|autophagosome membrane|autophagy of mitochondrion|cytosol|microtubule|cellular response to nitrogen starvation|endomembrane system|cytoplasmic vesicle MAP1LC3C 5.28828283259685 6.21704074628294 4.35952491891075 0.701221866933594 -0.512057109022706 0.763210291397638 1 0.22564 0.146239 0.0606944 0.198396 GeneID:440738,Genbank:XM_005273139.3,HGNC:HGNC:13353,MIM:609605 microtubule associated protein 1 light chain 3 gamma GO:0000045,GO:0000421,GO:0000422,GO:0005776,GO:0005829,GO:0005874,GO:0006995,GO:0009267,GO:0012505,GO:0016236,GO:0031090,GO:0031410,GO:0031625,GO:0035973,GO:0036464,GO:0097352 autophagosome assembly|autophagosome membrane|autophagy of mitochondrion|autophagosome|cytosol|microtubule|cellular response to nitrogen starvation|cellular response to starvation|endomembrane system|macroautophagy|organelle membrane|cytoplasmic vesicle|ubiquitin protein ligase binding|aggrephagy|cytoplasmic ribonucleoprotein granule|autophagosome maturation hsa04216 Ferroptosis MAP1S 722.113103620184 659.605302714991 784.620904525377 1.18953092295621 0.250392776442076 0.126381471674235 1 6.87995 7.01772 8.73751 8.12983 GeneID:55201,Genbank:NM_018174.5,HGNC:HGNC:15715,MIM:607573 microtubule associated protein 1S GO:0001578,GO:0003677,GO:0005634,GO:0005730,GO:0005819,GO:0005829,GO:0005874,GO:0006914,GO:0006915,GO:0007399,GO:0007420,GO:0008017,GO:0010848,GO:0015631,GO:0030054,GO:0030425,GO:0042802,GO:0042995,GO:0043025,GO:0045202,GO:0047497,GO:0048471,GO:0048487,GO:0048812,GO:0051015 microtubule bundle formation|DNA binding|nucleus|nucleolus|spindle|cytosol|microtubule|autophagy|apoptotic process|nervous system development|brain development|microtubule binding|regulation of chromatin disassembly|tubulin binding|cell junction|dendrite|identical protein binding|cell projection|neuronal cell body|synapse|mitochondrion transport along microtubule|perinuclear region of cytoplasm|beta-tubulin binding|neuron projection morphogenesis|actin filament binding MAP2 709.426291674001 542.930091429562 875.922491918439 1.61332463561209 0.690036768973059 0.130282393651706 1 1.59104 1.2873 2.90966 1.66386 GeneID:4133,Genbank:XM_024452891.1,HGNC:HGNC:6839,MIM:157130 microtubule associated protein 2 MAP2K1 2970.32473168948 3002.39204768339 2938.25741569557 0.978638821656451 -0.0311515806629673 0.812064616588455 1 26.6786 27.7104 26.9978 26.795 GeneID:5604,Genbank:NM_002755.3,HGNC:HGNC:6840,MIM:176872 mitogen-activated protein kinase kinase 1 GO:0000165,GO:0000187,GO:0004672,GO:0004674,GO:0004708,GO:0004712,GO:0004713,GO:0004728,GO:0005524,GO:0005634,GO:0005739,GO:0005769,GO:0005770,GO:0005783,GO:0005794,GO:0005815,GO:0005829,GO:0005886,GO:0005925,GO:0006468,GO:0006928,GO:0006935,GO:0007050,GO:0007165,GO:0007346,GO:0007507,GO:0008022,GO:0008285,GO:0010628,GO:0010629,GO:0018107,GO:0021697,GO:0030182,GO:0030216,GO:0030878,GO:0032872,GO:0035897,GO:0042981,GO:0043539,GO:0045893,GO:0047485,GO:0048538,GO:0048679,GO:0048870,GO:0050772,GO:0060020,GO:0060324,GO:0060440,GO:0060502,GO:0060674,GO:0060711,GO:0070062,GO:0070371,GO:0070374,GO:0071902,GO:0090170,GO:0090398,GO:0097110,GO:1903800,GO:2000641 MAPK cascade|activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|signal transducer, downstream of receptor, with protein tyrosine phosphatase activity|ATP binding|nucleus|mitochondrion|early endosome|late endosome|endoplasmic reticulum|Golgi apparatus|microtubule organizing center|cytosol|plasma membrane|focal adhesion|protein phosphorylation|movement of cell or subcellular component|chemotaxis|cell cycle arrest|signal transduction|regulation of mitotic cell cycle|heart development|protein C-terminus binding|negative regulation of cell proliferation|positive regulation of gene expression|negative regulation of gene expression|peptidyl-threonine phosphorylation|cerebellar cortex formation|neuron differentiation|keratinocyte differentiation|thyroid gland development|regulation of stress-activated MAPK cascade|proteolysis in other organism|regulation of apoptotic process|protein serine/threonine kinase activator activity|positive regulation of transcription, DNA-templated|protein N-terminus binding|thymus development|regulation of axon regeneration|cell motility|positive regulation of axonogenesis|Bergmann glial cell differentiation|face development|trachea formation|epithelial cell proliferation involved in lung morphogenesis|placenta blood vessel development|labyrinthine layer development|extracellular exosome|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein serine/threonine kinase activity|regulation of Golgi inheritance|cellular senescence|scaffold protein binding|positive regulation of production of miRNAs involved in gene silencing by miRNA|regulation of early endosome to late endosome transport hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04114,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04270,hsa04370,hsa04371,hsa04380,hsa04510,hsa04540,hsa04550,hsa04620,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa04934,hsa05020,hsa05034,hsa05161,hsa05163,hsa05164,hsa05165,hsa05167,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|Toll-like receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Prion diseases|Alcoholism|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer MAP2K2 5610.67338899533 5212.01196884007 6009.33480915058 1.1529779373258 0.205364906731925 0.129785303624738 1 61.9651 68.3952 77.0013 76.1978 GeneID:5605,Genbank:XM_006722799.2,HGNC:HGNC:6842,MIM:601263 mitogen-activated protein kinase kinase 2 GO:0000165,GO:0000187,GO:0004674,GO:0004708,GO:0004712,GO:0004713,GO:0005524,GO:0005576,GO:0005634,GO:0005739,GO:0005769,GO:0005770,GO:0005778,GO:0005783,GO:0005794,GO:0005829,GO:0005874,GO:0005886,GO:0005911,GO:0005925,GO:0007346,GO:0009898,GO:0010629,GO:0030165,GO:0032872,GO:0035897,GO:0036289,GO:0042981,GO:0043539,GO:0045893,GO:0046872,GO:0048471,GO:0070371,GO:0070374,GO:0071902,GO:0090170,GO:0097110,GO:1903800,GO:2000641 MAPK cascade|activation of MAPK activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|extracellular region|nucleus|mitochondrion|early endosome|late endosome|peroxisomal membrane|endoplasmic reticulum|Golgi apparatus|cytosol|microtubule|plasma membrane|cell-cell junction|focal adhesion|regulation of mitotic cell cycle|cytoplasmic side of plasma membrane|negative regulation of gene expression|PDZ domain binding|regulation of stress-activated MAPK cascade|proteolysis in other organism|peptidyl-serine autophosphorylation|regulation of apoptotic process|protein serine/threonine kinase activator activity|positive regulation of transcription, DNA-templated|metal ion binding|perinuclear region of cytoplasm|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein serine/threonine kinase activity|regulation of Golgi inheritance|scaffold protein binding|positive regulation of production of miRNAs involved in gene silencing by miRNA|regulation of early endosome to late endosome transport hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04066,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04270,hsa04370,hsa04371,hsa04540,hsa04550,hsa04620,hsa04650,hsa04660,hsa04662,hsa04664,hsa04720,hsa04722,hsa04730,hsa04810,hsa04910,hsa04912,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04934,hsa05020,hsa05161,hsa05163,hsa05164,hsa05165,hsa05167,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|VEGF signaling pathway|Apelin signaling pathway|Gap junction|Signaling pathways regulating pluripotency of stem cells|Toll-like receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Long-term potentiation|Neurotrophin signaling pathway|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Cushing syndrome|Prion diseases|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer MAP2K3 866.918549315377 908.010617575017 825.826481055738 0.909489894800168 -0.136870486480282 0.428075319040847 1 10.1277 12.5784 10.9788 10.1727 GeneID:5606,Genbank:NM_001316332.1,HGNC:HGNC:6843,MIM:602315 mitogen-activated protein kinase kinase 3 GO:0000187,GO:0004674,GO:0004708,GO:0004713,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006954,GO:0007165,GO:0007346,GO:0016020,GO:0019901,GO:0023014,GO:0031098,GO:0032147,GO:0035897,GO:0042035,GO:0042981,GO:0045860,GO:0045893,GO:0060048 activation of MAPK activity|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|ATP binding|nucleoplasm|cytoplasm|cytosol|inflammatory response|signal transduction|regulation of mitotic cell cycle|membrane|protein kinase binding|signal transduction by protein phosphorylation|stress-activated protein kinase signaling cascade|activation of protein kinase activity|proteolysis in other organism|regulation of cytokine biosynthetic process|regulation of apoptotic process|positive regulation of protein kinase activity|positive regulation of transcription, DNA-templated|cardiac muscle contraction hsa04010,hsa04015,hsa04218,hsa04620,hsa04664,hsa04668,hsa04714,hsa04750,hsa04912,hsa05014,hsa05145,hsa05164,hsa05169,hsa05170 MAPK signaling pathway|Rap1 signaling pathway|Cellular senescence|Toll-like receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Thermogenesis|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Amyotrophic lateral sclerosis (ALS)|Toxoplasmosis|Influenza A|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection MAP2K4 624.032877058728 705.295578954902 542.770175162553 0.769564125110246 -0.377886548549539 0.0232747987278746 0.616997337836357 5.6847 5.93744 4.47828 4.67234 GeneID:6416,Genbank:NM_001281435.1,HGNC:HGNC:6844,MIM:601335 mitogen-activated protein kinase kinase 4 hsa04010,hsa04012,hsa04620,hsa04664,hsa04668,hsa04912,hsa04926,hsa05120,hsa05142,hsa05161,hsa05164,hsa05166,hsa05167,hsa05169,hsa05418 MAPK signaling pathway|ErbB signaling pathway|Toll-like receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|GnRH signaling pathway|Relaxin signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Chagas disease (American trypanosomiasis)|Hepatitis B|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Fluid shear stress and atherosclerosis MAP2K5 419.11663563252 401.111419168564 437.121852096477 1.08977663364099 0.124032462927733 0.506043164403526 1 1.25678 1.36556 1.43838 1.49645 GeneID:5607,Genbank:NM_145160.2,HGNC:HGNC:6845,MIM:602520 mitogen-activated protein kinase kinase 5 GO:0000122,GO:0000187,GO:0004672,GO:0004674,GO:0004713,GO:0005524,GO:0005634,GO:0005737,GO:0005819,GO:0005829,GO:0007165,GO:0007346,GO:0007507,GO:0023014,GO:0030307,GO:0031098,GO:0032088,GO:0032147,GO:0034115,GO:0042981,GO:0043154,GO:0045415,GO:0045944,GO:0046872,GO:0050679,GO:0051247,GO:0060761,GO:0070375,GO:0071363,GO:0071499,GO:0090051,GO:2000342,GO:2001240 negative regulation of transcription from RNA polymerase II promoter|activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|spindle|cytosol|signal transduction|regulation of mitotic cell cycle|heart development|signal transduction by protein phosphorylation|positive regulation of cell growth|stress-activated protein kinase signaling cascade|negative regulation of NF-kappaB transcription factor activity|activation of protein kinase activity|negative regulation of heterotypic cell-cell adhesion|regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of interleukin-8 biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|positive regulation of epithelial cell proliferation|positive regulation of protein metabolic process|negative regulation of response to cytokine stimulus|ERK5 cascade|cellular response to growth factor stimulus|cellular response to laminar fluid shear stress|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of chemokine (C-X-C motif) ligand 2 production|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa04010,hsa04540,hsa04722,hsa04921,hsa05418 MAPK signaling pathway|Gap junction|Neurotrophin signaling pathway|Oxytocin signaling pathway|Fluid shear stress and atherosclerosis MAP2K6 59.7262897730599 60.8158631165431 58.6367164295768 0.964168120367044 -0.0526433661993742 0.899360788820876 1 0.148117 0.185333 0.140229 0.172159 GeneID:5608,Genbank:NM_002758.3,HGNC:HGNC:6846,MIM:601254 mitogen-activated protein kinase kinase 6 GO:0000187,GO:0002931,GO:0004674,GO:0004708,GO:0004713,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006351,GO:0006355,GO:0006915,GO:0006975,GO:0007050,GO:0007165,GO:0007346,GO:0019901,GO:0022602,GO:0023014,GO:0031098,GO:0032147,GO:0032308,GO:0035897,GO:0042493,GO:0042802,GO:0042981,GO:0043065,GO:0051770,GO:0060048,GO:0070423,GO:0070498,GO:0072709 activation of MAPK activity|response to ischemia|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|DNA damage induced protein phosphorylation|cell cycle arrest|signal transduction|regulation of mitotic cell cycle|protein kinase binding|ovulation cycle process|signal transduction by protein phosphorylation|stress-activated protein kinase signaling cascade|activation of protein kinase activity|positive regulation of prostaglandin secretion|proteolysis in other organism|response to drug|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|positive regulation of nitric-oxide synthase biosynthetic process|cardiac muscle contraction|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|cellular response to sorbitol hsa04010,hsa04015,hsa04218,hsa04380,hsa04620,hsa04664,hsa04668,hsa04750,hsa04912,hsa05014,hsa05145,hsa05163,hsa05164,hsa05167,hsa05169,hsa05170,hsa05418 MAPK signaling pathway|Rap1 signaling pathway|Cellular senescence|Osteoclast differentiation|Toll-like receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Amyotrophic lateral sclerosis (ALS)|Toxoplasmosis|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Fluid shear stress and atherosclerosis MAP2K7 1160.27676897607 1082.91401379569 1237.63952415645 1.14287885131197 0.192672481527236 0.286504265962902 1 11.4465 12.0631 12.8263 14.2524 GeneID:5609,Genbank:NM_001297555.1,HGNC:HGNC:6847,MIM:603014 mitogen-activated protein kinase kinase 7 GO:0000287,GO:0004674,GO:0004708,GO:0004713,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0006970,GO:0007165,GO:0007254,GO:0007257,GO:0007346,GO:0009408,GO:0009411,GO:0019899,GO:0019901,GO:0019903,GO:0032212,GO:0034612,GO:0035897,GO:0038095,GO:0042981,GO:0051403,GO:0051973,GO:1904355 magnesium ion binding|protein serine/threonine kinase activity|MAP kinase kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|apoptotic process|response to osmotic stress|signal transduction|JNK cascade|activation of JUN kinase activity|regulation of mitotic cell cycle|response to heat|response to UV|enzyme binding|protein kinase binding|protein phosphatase binding|positive regulation of telomere maintenance via telomerase|response to tumor necrosis factor|proteolysis in other organism|Fc-epsilon receptor signaling pathway|regulation of apoptotic process|stress-activated MAPK cascade|positive regulation of telomerase activity|positive regulation of telomere capping hsa04010,hsa04012,hsa04141,hsa04380,hsa04530,hsa04620,hsa04660,hsa04664,hsa04668,hsa04722,hsa04912,hsa04926,hsa05164,hsa05167,hsa05169,hsa05170,hsa05418 MAPK signaling pathway|ErbB signaling pathway|Protein processing in endoplasmic reticulum|Osteoclast differentiation|Tight junction|Toll-like receptor signaling pathway|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Relaxin signaling pathway|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Fluid shear stress and atherosclerosis MAP3K1 305.611997181869 332.982702642237 278.241291721502 0.835602839167443 -0.25911070056057 0.444565154964607 1 1.28534 1.26921 1.32757 0.760182 GeneID:4214,Genbank:NM_005921.1,HGNC:HGNC:6848,MIM:600982 mitogen-activated protein kinase kinase kinase 1 GO:0002755,GO:0004672,GO:0004674,GO:0004709,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0007346,GO:0008270,GO:0019901,GO:0023014,GO:0031098,GO:0032147,GO:0038095,GO:0042981,GO:0071260 MyD88-dependent toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|regulation of mitotic cell cycle|zinc ion binding|protein kinase binding|signal transduction by protein phosphorylation|stress-activated protein kinase signaling cascade|activation of protein kinase activity|Fc-epsilon receptor signaling pathway|regulation of apoptotic process|cellular response to mechanical stimulus hsa04010,hsa04120,hsa04530,hsa04622,hsa04722,hsa04912,hsa05161,hsa05166 MAPK signaling pathway|Ubiquitin mediated proteolysis|Tight junction|RIG-I-like receptor signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Hepatitis B|Human T-cell leukemia virus 1 infection MAP3K10 535.767008397309 506.946207680283 564.587809114335 1.11370358543131 0.155365307425392 0.384631463389278 1 4.44972 4.81135 5.57173 5.35254 GeneID:4294,Genbank:XM_011526981.2,HGNC:HGNC:6849,MIM:600137 mitogen-activated protein kinase kinase kinase 10 GO:0003714,GO:0004672,GO:0004674,GO:0004706,GO:0005524,GO:0005737,GO:0006915,GO:0007165,GO:0007224,GO:0007254,GO:0007257,GO:0018105,GO:0018107,GO:0042803,GO:0043065,GO:0043425,GO:0043433,GO:0043507,GO:0045892,GO:0046330,GO:0046777 transcription corepressor activity|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|ATP binding|cytoplasm|apoptotic process|signal transduction|smoothened signaling pathway|JNK cascade|activation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein homodimerization activity|positive regulation of apoptotic process|bHLH transcription factor binding|negative regulation of DNA binding transcription factor activity|positive regulation of JUN kinase activity|negative regulation of transcription, DNA-templated|positive regulation of JNK cascade|protein autophosphorylation MAP3K11 1325.41877867213 1319.12436153572 1331.71319580854 1.0095433263458 0.0137028278193679 0.951248327892645 1 15.6749 16.031 15.8246 16.413 GeneID:4296,Genbank:NM_002419.3,HGNC:HGNC:6850,MIM:600050 mitogen-activated protein kinase kinase kinase 11 GO:0000187,GO:0004672,GO:0004674,GO:0004706,GO:0005524,GO:0005737,GO:0005813,GO:0005874,GO:0006468,GO:0007017,GO:0007254,GO:0007257,GO:0008219,GO:0008283,GO:0016020,GO:0031434,GO:0031435,GO:0042802,GO:0042803,GO:0043065,GO:0043507,GO:0043525,GO:0046330,GO:0046777,GO:0048365 activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|JUN kinase kinase kinase activity|ATP binding|cytoplasm|centrosome|microtubule|protein phosphorylation|microtubule-based process|JNK cascade|activation of JUN kinase activity|cell death|cell proliferation|membrane|mitogen-activated protein kinase kinase binding|mitogen-activated protein kinase kinase kinase binding|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|positive regulation of JUN kinase activity|positive regulation of neuron apoptotic process|positive regulation of JNK cascade|protein autophosphorylation|Rac GTPase binding hsa04010,hsa04932 MAPK signaling pathway|Non-alcoholic fatty liver disease (NAFLD) MAP3K12 403.527487492987 368.488357646376 438.566617339598 1.19017767655084 0.251176963402452 0.171439421176183 1 1.73902 1.68827 1.97802 2.15965 GeneID:7786,Genbank:XM_011538725.3,HGNC:HGNC:6851,MIM:600447 mitogen-activated protein kinase kinase kinase 12 GO:0000165,GO:0004672,GO:0004674,GO:0004709,GO:0004871,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007254,GO:0016020,GO:0016572,GO:0018105,GO:0018107,GO:0019901,GO:0030424,GO:0030426,GO:0035556,GO:0042803,GO:0046777,GO:2000672 MAPK cascade|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|signal transducer activity|ATP binding|cytoplasm|cytosol|plasma membrane|protein phosphorylation|JNK cascade|membrane|histone phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein kinase binding|axon|growth cone|intracellular signal transduction|protein homodimerization activity|protein autophosphorylation|negative regulation of motor neuron apoptotic process hsa04010 MAPK signaling pathway MAP3K13 256.574446001387 262.58694255061 250.561949452164 0.954205670009168 -0.0676278358657046 0.754000565752934 1 0.507884 0.428048 0.477717 0.405975 GeneID:9175,Genbank:XM_017007456.1,HGNC:HGNC:6852,MIM:604915 mitogen-activated protein kinase kinase kinase 13 GO:0000186,GO:0004674,GO:0004709,GO:0005524,GO:0005737,GO:0006468,GO:0007254,GO:0016020,GO:0019901,GO:0042802,GO:0042803,GO:0046777,GO:0046872,GO:0051092 activation of MAPKK activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|ATP binding|cytoplasm|protein phosphorylation|JNK cascade|membrane|protein kinase binding|identical protein binding|protein homodimerization activity|protein autophosphorylation|metal ion binding|positive regulation of NF-kappaB transcription factor activity hsa04010 MAPK signaling pathway MAP3K14 1345.25618865691 1527.4202566744 1163.09212063942 0.761474856416915 -0.39313169457861 0.00674290443134459 0.325284208953057 10.3275 11.2616 8.51727 8.32974 GeneID:9020,Genbank:NM_003954.4,HGNC:HGNC:6853,MIM:604655 mitogen-activated protein kinase kinase kinase 14 GO:0001650,GO:0004672,GO:0004674,GO:0004704,GO:0004709,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006955,GO:0007249,GO:0007346,GO:0016301,GO:0023014,GO:0031098,GO:0031295,GO:0032147,GO:0033209,GO:0038061,GO:0042981,GO:0043123,GO:0043231,GO:0051607,GO:0071260 fibrillar center|protein kinase activity|protein serine/threonine kinase activity|NF-kappaB-inducing kinase activity|MAP kinase kinase kinase activity|ATP binding|nucleus|cytoplasm|cytosol|immune response|I-kappaB kinase/NF-kappaB signaling|regulation of mitotic cell cycle|kinase activity|signal transduction by protein phosphorylation|stress-activated protein kinase signaling cascade|T cell costimulation|activation of protein kinase activity|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|defense response to virus|cellular response to mechanical stimulus hsa04010,hsa04064,hsa04210,hsa04380,hsa04625,hsa04660,hsa04668,hsa04672,hsa05120,hsa05166,hsa05169 MAPK signaling pathway|NF-kappa B signaling pathway|Apoptosis|Osteoclast differentiation|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|TNF signaling pathway|Intestinal immune network for IgA production|Epithelial cell signaling in Helicobacter pylori infection|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection MAP3K15 15.209828808439 18.3051296609463 12.1145279559317 0.661810551485896 -0.595509801642734 0.484331038590257 1 0.0536444 0.0199034 0.0306437 0.0428428 GeneID:389840,Genbank:NM_001001671.3,HGNC:HGNC:31689,MIM:300820 mitogen-activated protein kinase kinase kinase 15 GO:0000186,GO:0004709,GO:0005524,GO:0005622,GO:0046872 activation of MAPKK activity|MAP kinase kinase kinase activity|ATP binding|intracellular|metal ion binding MAP3K2 420.755766063859 402.810939091898 438.700593035821 1.08909801214643 0.123133793609242 0.776046216971773 1 1.70061 1.38396 2.21232 1.17577 GeneID:10746,Genbank:NM_006609.4,HGNC:HGNC:6854,MIM:609487 mitogen-activated protein kinase kinase kinase 2 GO:0000187,GO:0004672,GO:0004674,GO:0004709,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0007257,GO:0007346,GO:0019901,GO:0042981,GO:0045893,GO:0046872,GO:0071260 activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|ATP binding|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|activation of JUN kinase activity|regulation of mitotic cell cycle|protein kinase binding|regulation of apoptotic process|positive regulation of transcription, DNA-templated|metal ion binding|cellular response to mechanical stimulus hsa04010,hsa04540,hsa04912 MAPK signaling pathway|Gap junction|GnRH signaling pathway MAP3K20 594.13609798335 628.960110109139 559.312085857561 0.889264798940122 -0.169315016401621 0.433843305847754 1 2.31287 1.92153 2.15693 1.63459 GeneID:51776,Genbank:XM_017004324.1,HGNC:HGNC:17797,MIM:609479 mitogen-activated protein kinase kinase kinase 20 GO:0000075,GO:0000077,GO:0000186,GO:0000287,GO:0003723,GO:0004674,GO:0004709,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0006950,GO:0007010,GO:0007050,GO:0007257,GO:0008219,GO:0008283,GO:0009314,GO:0030154,GO:0035556,GO:0042733,GO:0043065,GO:0060173 cell cycle checkpoint|DNA damage checkpoint|activation of MAPKK activity|magnesium ion binding|RNA binding|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|response to stress|cytoskeleton organization|cell cycle arrest|activation of JUN kinase activity|cell death|cell proliferation|response to radiation|cell differentiation|intracellular signal transduction|embryonic digit morphogenesis|positive regulation of apoptotic process|limb development hsa04010 MAPK signaling pathway MAP3K21 113.073927793339 133.565927668587 92.5819279180913 0.693155279449802 -0.528749516265248 0.0628321696850245 0.893712282127312 1.05642 0.940483 0.780472 0.535954 GeneID:84451,Genbank:XM_011544305.2,HGNC:HGNC:29798,MIM:614793 mitogen-activated protein kinase kinase kinase 21 GO:0004706,GO:0005524,GO:0005737,GO:0006468,GO:0007257,GO:0042803,GO:0046777 JUN kinase kinase kinase activity|ATP binding|cytoplasm|protein phosphorylation|activation of JUN kinase activity|protein homodimerization activity|protein autophosphorylation MAP3K3 787.175893065603 799.407888440077 774.943897691128 0.969397361343674 -0.0448399393291782 0.760041189076678 1 5.87122 6.22316 6.3186 5.73842 GeneID:4215,Genbank:XM_005257378.2,HGNC:HGNC:6855,MIM:602539 mitogen-activated protein kinase kinase kinase 3 GO:0000165,GO:0001568,GO:0004672,GO:0004674,GO:0004709,GO:0005524,GO:0005737,GO:0005829,GO:0007346,GO:0031098,GO:0032147,GO:0035556,GO:0042981,GO:0043123,GO:0046777,GO:0046872,GO:0070498,GO:1900745 MAPK cascade|blood vessel development|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|ATP binding|cytoplasm|cytosol|regulation of mitotic cell cycle|stress-activated protein kinase signaling cascade|activation of protein kinase activity|intracellular signal transduction|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein autophosphorylation|metal ion binding|interleukin-1-mediated signaling pathway|positive regulation of p38MAPK cascade hsa04010,hsa04722,hsa04912,hsa05166 MAPK signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Human T-cell leukemia virus 1 infection MAP3K4 2110.76889792602 2032.76670363069 2188.77109222134 1.07674485631431 0.106676431740844 0.468863555078732 1 10.5392 9.78447 12.6148 9.83485 GeneID:4216,Genbank:XM_017010869.1,HGNC:HGNC:6856,MIM:602425 mitogen-activated protein kinase kinase kinase 4 GO:0000186,GO:0001890,GO:0004709,GO:0005524,GO:0005737,GO:0007346,GO:0010225,GO:0010468,GO:0019100,GO:0032212,GO:0035556,GO:0042981,GO:0043507,GO:0046872,GO:0048471,GO:0051973,GO:0060718,GO:1900745,GO:1904355 activation of MAPKK activity|placenta development|MAP kinase kinase kinase activity|ATP binding|cytoplasm|regulation of mitotic cell cycle|response to UV-C|regulation of gene expression|male germ-line sex determination|positive regulation of telomere maintenance via telomerase|intracellular signal transduction|regulation of apoptotic process|positive regulation of JUN kinase activity|metal ion binding|perinuclear region of cytoplasm|positive regulation of telomerase activity|chorionic trophoblast cell differentiation|positive regulation of p38MAPK cascade|positive regulation of telomere capping hsa04010,hsa04912 MAPK signaling pathway|GnRH signaling pathway MAP3K5 536.186980832594 545.535352919366 526.838608745822 0.965727713018981 -0.0503116164379276 0.776781356464328 1 2.42795 2.60465 2.73677 2.1587 GeneID:4217,Genbank:XM_017010875.1,HGNC:HGNC:6857,MIM:602448 mitogen-activated protein kinase kinase kinase 5 GO:0000165,GO:0000186,GO:0000287,GO:0002931,GO:0004672,GO:0004674,GO:0004709,GO:0005524,GO:0005829,GO:0006468,GO:0007254,GO:0007257,GO:0008631,GO:0009897,GO:0010666,GO:0016032,GO:0019901,GO:0019903,GO:0019904,GO:0034198,GO:0034976,GO:0038066,GO:0042060,GO:0042802,GO:0042803,GO:0043065,GO:0043234,GO:0043280,GO:0043507,GO:0045087,GO:0045663,GO:0045893,GO:0046330,GO:0051403,GO:0070059,GO:0070301,GO:0071356,GO:0072577,GO:0097190,GO:0097300,GO:1900745,GO:1901216,GO:1902170,GO:1902911,GO:1904707,GO:1990604 MAPK cascade|activation of MAPKK activity|magnesium ion binding|response to ischemia|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|ATP binding|cytosol|protein phosphorylation|JNK cascade|activation of JUN kinase activity|intrinsic apoptotic signaling pathway in response to oxidative stress|external side of plasma membrane|positive regulation of cardiac muscle cell apoptotic process|viral process|protein kinase binding|protein phosphatase binding|protein domain specific binding|cellular response to amino acid starvation|response to endoplasmic reticulum stress|p38MAPK cascade|wound healing|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|protein complex|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of JUN kinase activity|innate immune response|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of JNK cascade|stress-activated MAPK cascade|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to hydrogen peroxide|cellular response to tumor necrosis factor|endothelial cell apoptotic process|apoptotic signaling pathway|programmed necrotic cell death|positive regulation of p38MAPK cascade|positive regulation of neuron death|cellular response to reactive nitrogen species|protein kinase complex|positive regulation of vascular smooth muscle cell proliferation|IRE1-TRAF2-ASK1 complex hsa01524,hsa04010,hsa04071,hsa04141,hsa04210,hsa04530,hsa04668,hsa04714,hsa04722,hsa04932,hsa05014,hsa05418 Platinum drug resistance|MAPK signaling pathway|Sphingolipid signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Tight junction|TNF signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Non-alcoholic fatty liver disease (NAFLD)|Amyotrophic lateral sclerosis (ALS)|Fluid shear stress and atherosclerosis MAP3K6 629.651679701902 562.438928960196 696.864430443608 1.23900461821149 0.30918156492678 0.0770997299696708 0.94157495521624 3.37216 4.01904 4.67869 4.9442 GeneID:9064,Genbank:NM_001297609.1,HGNC:HGNC:6858,MIM:604468 mitogen-activated protein kinase kinase kinase 6 GO:0000287,GO:0004709,GO:0005524,GO:0005622,GO:0006468,GO:0007165,GO:0007257 magnesium ion binding|MAP kinase kinase kinase activity|ATP binding|intracellular|protein phosphorylation|signal transduction|activation of JUN kinase activity hsa04010 MAPK signaling pathway MAP3K7 696.69534561452 761.36359853018 632.02709269886 0.830125177929434 -0.268599192209581 0.175036162594762 1 5.59521 5.02223 5.30728 3.80856 GeneID:6885,Genbank:NM_145333.2,HGNC:HGNC:6859,MIM:602614 mitogen-activated protein kinase kinase kinase 7 GO:0000186,GO:0000187,GO:0000287,GO:0002726,GO:0004709,GO:0005524,GO:0005622,GO:0005671,GO:0005886,GO:0006351,GO:0006355,GO:0006915,GO:0007250,GO:0007252,GO:0007254,GO:0008385,GO:0032743,GO:0042802,GO:0043123,GO:0043507,GO:0043966,GO:0097110 activation of MAPKK activity|activation of MAPK activity|magnesium ion binding|positive regulation of T cell cytokine production|MAP kinase kinase kinase activity|ATP binding|intracellular|Ada2/Gcn5/Ada3 transcription activator complex|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|activation of NF-kappaB-inducing kinase activity|I-kappaB phosphorylation|JNK cascade|IkappaB kinase complex|positive regulation of interleukin-2 production|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JUN kinase activity|histone H3 acetylation|scaffold protein binding hsa04010,hsa04064,hsa04140,hsa04152,hsa04310,hsa04380,hsa04520,hsa04620,hsa04621,hsa04622,hsa04657,hsa04660,hsa04668,hsa05140,hsa05145,hsa05162,hsa05168,hsa05169,hsa05170,hsa05418 MAPK signaling pathway|NF-kappa B signaling pathway|Autophagy - animal|AMPK signaling pathway|Wnt signaling pathway|Osteoclast differentiation|Adherens junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|T cell receptor signaling pathway|TNF signaling pathway|Leishmaniasis|Toxoplasmosis|Measles|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Fluid shear stress and atherosclerosis MAP3K7CL 9.58546082486377 12.3860552178809 6.7848664318466 0.547782672731164 -0.868324462944438 0.377272780003635 1 0.133981 0.114298 0.0815421 0.0650243 GeneID:56911,Genbank:NM_020152.3,HGNC:HGNC:16457,MIM:611110 MAP3K7 C-terminal like GO:0000186,GO:0004709,GO:0005634,GO:0005829 activation of MAPKK activity|MAP kinase kinase kinase activity|nucleus|cytosol MAP3K8 32.6686745294218 38.1961433873504 27.1412056714932 0.710574504767454 -0.492942168820836 0.317066553643832 1 0.10759 0.145613 0.141494 0.121476 GeneID:1326,Genbank:NM_005204.3,HGNC:HGNC:6860,MIM:191195 mitogen-activated protein kinase kinase kinase 8 hsa04010,hsa04620,hsa04660,hsa04668 MAPK signaling pathway|Toll-like receptor signaling pathway|T cell receptor signaling pathway|TNF signaling pathway MAP3K9 446.707401216003 460.601146903289 432.813655528717 0.939671250144744 -0.089771985695086 0.613139241051469 1 1.25248 1.3009 1.34838 1.103 GeneID:4293,Genbank:XM_005267683.5,HGNC:HGNC:6861,MIM:600136 mitogen-activated protein kinase kinase kinase 9 GO:0004674,GO:0004706,GO:0004708,GO:0005524,GO:0005737,GO:0006351,GO:0006355,GO:0006468,GO:0006915,GO:0007257,GO:0042803,GO:0043065,GO:0046777 protein serine/threonine kinase activity|JUN kinase kinase kinase activity|MAP kinase kinase activity|ATP binding|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|activation of JUN kinase activity|protein homodimerization activity|positive regulation of apoptotic process|protein autophosphorylation MAP4 12321.3986222528 11741.9344213376 12900.8628231679 1.09869995524113 0.135797453450837 0.297825832321848 1 26.6469 27.9278 29.827 30.6221 GeneID:4134,Genbank:NM_001134364.1,HGNC:HGNC:6862,MIM:157132 microtubule associated protein 4 MAP4K1 8.15479950075172 7.10113100082778 9.20846800067565 1.29676075537858 0.374912335513563 0.776814773997871 1 0.0366938 0.0748822 0.0907738 0.0424909 GeneID:11184,Genbank:NM_001042600.2,HGNC:HGNC:6863,MIM:601983 mitogen-activated protein kinase kinase kinase kinase 1 GO:0000185,GO:0004672,GO:0004674,GO:0005524,GO:0005737,GO:0006468,GO:0006950,GO:0007257,GO:0007346,GO:0008283,GO:0008349,GO:0016020,GO:0018105,GO:0035556,GO:0042981,GO:0046777 activation of MAPKKK activity|protein kinase activity|protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation|response to stress|activation of JUN kinase activity|regulation of mitotic cell cycle|cell proliferation|MAP kinase kinase kinase kinase activity|membrane|peptidyl-serine phosphorylation|intracellular signal transduction|regulation of apoptotic process|protein autophosphorylation hsa04010 MAPK signaling pathway MAP4K2 550.572417135821 536.609223480511 564.535610791131 1.05204231699464 0.0731927362751383 0.732900969711956 1 2.44782 2.68279 2.53814 3.04626 GeneID:5871,Genbank:XM_017018093.2,HGNC:HGNC:6864,MIM:603166 mitogen-activated protein kinase kinase kinase kinase 2 GO:0000139,GO:0004674,GO:0005524,GO:0005737,GO:0006468,GO:0006903,GO:0006955,GO:0007254,GO:0007257,GO:0007346,GO:0008349,GO:0016323,GO:0031435,GO:0035556,GO:0042981,GO:0045087,GO:0046330 Golgi membrane|protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation|vesicle targeting|immune response|JNK cascade|activation of JUN kinase activity|regulation of mitotic cell cycle|MAP kinase kinase kinase kinase activity|basolateral plasma membrane|mitogen-activated protein kinase kinase kinase binding|intracellular signal transduction|regulation of apoptotic process|innate immune response|positive regulation of JNK cascade hsa04010 MAPK signaling pathway MAP4K3 336.062211089551 355.621022680791 316.503399498311 0.890001938334246 -0.168119616760958 0.564296619847517 1 2.85698 2.29673 2.48618 1.83149 GeneID:8491,Genbank:XM_024453183.1,HGNC:HGNC:6865,MIM:604921 mitogen-activated protein kinase kinase kinase kinase 3 GO:0004672,GO:0004674,GO:0005524,GO:0005737,GO:0006468,GO:0007254,GO:0007346,GO:0008349,GO:0009411,GO:0034612,GO:0035556,GO:0042981 protein kinase activity|protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation|JNK cascade|regulation of mitotic cell cycle|MAP kinase kinase kinase kinase activity|response to UV|response to tumor necrosis factor|intracellular signal transduction|regulation of apoptotic process hsa04010 MAPK signaling pathway MAP4K4 6000.59330091652 5691.97344509308 6309.21315673997 1.10844037091898 0.148531161821498 0.251574807555513 1 22.0461 20.5771 25.6351 21.978 GeneID:9448,Genbank:NM_145686.3,HGNC:HGNC:6866,MIM:604666 mitogen-activated protein kinase kinase kinase kinase 4 GO:0004111,GO:0004674,GO:0005524,GO:0005737,GO:0006468,GO:0007346,GO:0008349,GO:0035556,GO:0043066,GO:0046328,GO:0048812,GO:0061179,GO:0070571 creatine kinase activity|protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation|regulation of mitotic cell cycle|MAP kinase kinase kinase kinase activity|intracellular signal transduction|negative regulation of apoptotic process|regulation of JNK cascade|neuron projection morphogenesis|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of neuron projection regeneration hsa04010 MAPK signaling pathway MAP4K5 416.700714567812 462.118370382992 371.283058752632 0.80343713331483 -0.315742953380582 0.230986460610032 1 2.1891 2.16272 2.145 1.50933 GeneID:11183,Genbank:XM_011536378.3,HGNC:HGNC:6867,MIM:604923 mitogen-activated protein kinase kinase kinase kinase 5 GO:0004672,GO:0004674,GO:0005524,GO:0005737,GO:0006468,GO:0007257,GO:0007346,GO:0008349,GO:0035556,GO:0042981 protein kinase activity|protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation|activation of JUN kinase activity|regulation of mitotic cell cycle|MAP kinase kinase kinase kinase activity|intracellular signal transduction|regulation of apoptotic process MAP6 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00608015 0 0.00574027 0 GeneID:4135,Genbank:XM_017017755.2,HGNC:HGNC:6868,MIM:601783 microtubule associated protein 6 GO:0000226,GO:0005516,GO:0005794,GO:0005874,GO:0008017,GO:0030424,GO:0030425,GO:0030658,GO:0032418,GO:0048471,GO:0048813 microtubule cytoskeleton organization|calmodulin binding|Golgi apparatus|microtubule|microtubule binding|axon|dendrite|transport vesicle membrane|lysosome localization|perinuclear region of cytoplasm|dendrite morphogenesis MAP6D1 232.689290916582 225.976683228718 239.401898604446 1.05940973725214 0.0832606739148364 0.725579322164344 1 4.69808 5.12604 5.40902 5.29752 GeneID:79929,Genbank:NM_024871.2,HGNC:HGNC:25753,MIM:610593 MAP6 domain containing 1 GO:0000226,GO:0005516,GO:0005794,GO:0005798,GO:0005801,GO:0005874,GO:0007026,GO:0008017,GO:0018009,GO:0032418,GO:0048813 microtubule cytoskeleton organization|calmodulin binding|Golgi apparatus|Golgi-associated vesicle|cis-Golgi network|microtubule|negative regulation of microtubule depolymerization|microtubule binding|N-terminal peptidyl-L-cysteine N-palmitoylation|lysosome localization|dendrite morphogenesis MAP7 141.231590016224 137.544333814039 144.918846218409 1.05361553035213 0.0753485162697748 0.798161575341404 1 0.503829 0.574911 0.692654 0.48922 GeneID:9053,Genbank:NM_001198617.1,HGNC:HGNC:6869,MIM:604108 microtubule associated protein 7 GO:0000226,GO:0005102,GO:0005198,GO:0005829,GO:0005874,GO:0005875,GO:0006970,GO:0007163,GO:0015630,GO:0016323,GO:0048471,GO:0072659 microtubule cytoskeleton organization|receptor binding|structural molecule activity|cytosol|microtubule|microtubule associated complex|response to osmotic stress|establishment or maintenance of cell polarity|microtubule cytoskeleton|basolateral plasma membrane|perinuclear region of cytoplasm|protein localization to plasma membrane MAP7D1 6269.40551715308 6040.12707123751 6498.68396306865 1.07591841801057 0.105568689052791 0.431830403735184 1 60.8287 59.6675 65.7898 66.8463 GeneID:55700,Genbank:NM_018067.4,HGNC:HGNC:25514 MAP7 domain containing 1 GO:0000226,GO:0005198,GO:0005819,GO:0005829,GO:0015630 microtubule cytoskeleton organization|structural molecule activity|spindle|cytosol|microtubule cytoskeleton MAP7D2 4.02182109649548 4.65077399104097 3.39286820195 0.729527646040392 -0.45496544361242 0.847851047107628 1 0.0183428 0.00858836 0.0175269 0.00814379 GeneID:256714,Genbank:NM_001168466.1,HGNC:HGNC:25899 MAP7 domain containing 2 GO:0000226,GO:0005198,GO:0015630 microtubule cytoskeleton organization|structural molecule activity|microtubule cytoskeleton MAP7D3 401.501888659702 431.263489369894 371.74028794951 0.86197950235168 -0.214274532077842 0.344259975719254 1 2.18013 1.72883 1.98073 1.54169 GeneID:79649,Genbank:NM_001173517.1,HGNC:HGNC:25742,MIM:300930 MAP7 domain containing 3 GO:0000226,GO:0005198,GO:0005737,GO:0005819,GO:0008017,GO:0015630,GO:0015631,GO:0016020,GO:0046785 microtubule cytoskeleton organization|structural molecule activity|cytoplasm|spindle|microtubule binding|microtubule cytoskeleton|tubulin binding|membrane|microtubule polymerization MAP9 59.2210037261103 60.7580281867502 57.6839792654704 0.949405057849619 -0.0749043593025261 0.874973398732631 1 0.318186 0.279187 0.370126 0.222617 GeneID:79884,Genbank:XM_011532255.3,HGNC:HGNC:26118,MIM:610070 microtubule associated protein 9 GO:0000235,GO:0000910,GO:0005737,GO:0008017,GO:0046602,GO:0051233,GO:0060236,GO:0072686,GO:0090307,GO:1902412,GO:1990023 astral microtubule|cytokinesis|cytoplasm|microtubule binding|regulation of mitotic centrosome separation|spindle midzone|regulation of mitotic spindle organization|mitotic spindle|mitotic spindle assembly|regulation of mitotic cytokinesis|mitotic spindle midzone MAPK1 2835.36008453223 2707.48676756635 2963.2334014981 1.09445905220864 0.130217978931254 0.332512190629852 1 20.384 19.577 24.4665 19.9024 GeneID:5594,Genbank:NM_002745.4,HGNC:HGNC:6871,MIM:176948 mitogen-activated protein kinase 1 hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04114,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04261,hsa04270,hsa04350,hsa04360,hsa04370,hsa04371,hsa04380,hsa04510,hsa04520,hsa04540,hsa04550,hsa04611,hsa04620,hsa04621,hsa04625,hsa04650,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04713,hsa04720,hsa04722,hsa04723,hsa04724,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa04930,hsa04933,hsa04934,hsa04960,hsa05010,hsa05020,hsa05034,hsa05131,hsa05132,hsa05133,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05167,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|TGF-beta signaling pathway|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Adherens junction|Gap junction|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Type II diabetes mellitus|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Aldosterone-regulated sodium reabsorption|Alzheimer disease|Prion diseases|Alcoholism|Shigellosis|Salmonella infection|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer MAPK10 61.6100537211399 59.7396677632585 63.4804396790213 1.06261788951668 0.0876229063668191 0.847195883978714 1 0.0931109 0.129462 0.117113 0.12084 GeneID:5602,Genbank:NM_002753.4,HGNC:HGNC:6872,MIM:602897 mitogen-activated protein kinase 10 hsa01522,hsa04010,hsa04012,hsa04014,hsa04024,hsa04068,hsa04071,hsa04137,hsa04140,hsa04141,hsa04210,hsa04215,hsa04217,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04664,hsa04668,hsa04722,hsa04723,hsa04728,hsa04750,hsa04910,hsa04912,hsa04914,hsa04917,hsa04920,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa05120,hsa05131,hsa05132,hsa05133,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05164,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05210,hsa05212,hsa05231,hsa05418 Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Necroptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis MAPK11 205.94123143929 193.335021397169 218.547441481411 1.13040793076205 0.176843492538689 0.584337932446465 1 2.62013 3.66907 3.37451 3.82499 GeneID:5600,Genbank:NM_002751.6,HGNC:HGNC:6873,MIM:602898 mitogen-activated protein kinase 11 hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa05014,hsa05120,hsa05131,hsa05132,hsa05133,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05163,hsa05164,hsa05167,hsa05169,hsa05170,hsa05205,hsa05418 Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Amyotrophic lateral sclerosis (ALS)|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer|Fluid shear stress and atherosclerosis MAPK12 436.632634260216 424.519176602931 448.746091917501 1.05706907166936 0.080069649283609 0.671546672861386 1 8.77928 8.47371 8.93765 9.34165 GeneID:6300,Genbank:NM_001303252.2,HGNC:HGNC:6874,MIM:602399 mitogen-activated protein kinase 12 hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04114,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa05014,hsa05120,hsa05131,hsa05132,hsa05133,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05163,hsa05164,hsa05167,hsa05169,hsa05170,hsa05205,hsa05418 Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Amyotrophic lateral sclerosis (ALS)|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer|Fluid shear stress and atherosclerosis MAPK13 14.7537863372234 17.8728931887818 11.6346794856649 0.65096788543265 -0.619341723032377 0.415170856110865 1 0.102317 0.1237 0.102824 0.0420511 GeneID:5603,Genbank:NM_002754.4,HGNC:HGNC:6875,MIM:602899 mitogen-activated protein kinase 13 hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa05014,hsa05120,hsa05131,hsa05132,hsa05133,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05163,hsa05164,hsa05167,hsa05169,hsa05170,hsa05205,hsa05418 Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Amyotrophic lateral sclerosis (ALS)|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer|Fluid shear stress and atherosclerosis MAPK14 1665.09545072442 1749.44490872042 1580.74599272841 0.90357003232791 -0.146291671576522 0.312428096104938 1 8.29157 7.82301 6.97145 7.84072 GeneID:1432,Genbank:NM_139012.2,HGNC:HGNC:6876,MIM:600289 mitogen-activated protein kinase 14 GO:0000077,GO:0000902,GO:0000922,GO:0001502,GO:0001525,GO:0001890,GO:0002062,GO:0002741,GO:0004707,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006006,GO:0006351,GO:0006357,GO:0006915,GO:0007178,GO:0007519,GO:0010468,GO:0010759,GO:0010831,GO:0014835,GO:0016607,GO:0018105,GO:0019395,GO:0019903,GO:0030278,GO:0030316,GO:0031281,GO:0031663,GO:0032495,GO:0035556,GO:0035924,GO:0035994,GO:0038066,GO:0042307,GO:0042770,GO:0045648,GO:0045663,GO:0045944,GO:0046326,GO:0048010,GO:0048273,GO:0051146,GO:0051525,GO:0060045,GO:0071223,GO:0071356,GO:0071479,GO:0090090,GO:0090336,GO:0090400,GO:0098586,GO:1900015,GO:1901741,GO:1905050,GO:2000379,GO:2001184 DNA damage checkpoint|cell morphogenesis|spindle pole|cartilage condensation|angiogenesis|placenta development|chondrocyte differentiation|positive regulation of cytokine secretion involved in immune response|MAP kinase activity|ATP binding|nucleus|cytoplasm|mitochondrion|cytosol|glucose metabolic process|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|apoptotic process|transmembrane receptor protein serine/threonine kinase signaling pathway|skeletal muscle tissue development|regulation of gene expression|positive regulation of macrophage chemotaxis|positive regulation of myotube differentiation|myoblast differentiation involved in skeletal muscle regeneration|nuclear speck|peptidyl-serine phosphorylation|fatty acid oxidation|protein phosphatase binding|regulation of ossification|osteoclast differentiation|positive regulation of cyclase activity|lipopolysaccharide-mediated signaling pathway|response to muramyl dipeptide|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|response to muscle stretch|p38MAPK cascade|positive regulation of protein import into nucleus|signal transduction in response to DNA damage|positive regulation of erythrocyte differentiation|positive regulation of myoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of glucose import|vascular endothelial growth factor receptor signaling pathway|mitogen-activated protein kinase p38 binding|striated muscle cell differentiation|NFAT protein binding|positive regulation of cardiac muscle cell proliferation|cellular response to lipoteichoic acid|cellular response to tumor necrosis factor|cellular response to ionizing radiation|negative regulation of canonical Wnt signaling pathway|positive regulation of brown fat cell differentiation|stress-induced premature senescence|cellular response to virus|regulation of cytokine production involved in inflammatory response|positive regulation of myoblast fusion|positive regulation of metallopeptidase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of interleukin-12 secretion hsa01522,hsa04010,hsa04015,hsa04068,hsa04071,hsa04218,hsa04261,hsa04370,hsa04380,hsa04550,hsa04611,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04670,hsa04714,hsa04722,hsa04723,hsa04728,hsa04750,hsa04912,hsa04914,hsa04917,hsa04926,hsa04933,hsa05014,hsa05120,hsa05131,hsa05132,hsa05133,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05163,hsa05164,hsa05167,hsa05169,hsa05170,hsa05205,hsa05418 Endocrine resistance|MAPK signaling pathway|Rap1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Cellular senescence|Adrenergic signaling in cardiomyocytes|VEGF signaling pathway|Osteoclast differentiation|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Leukocyte transendothelial migration|Thermogenesis|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Amyotrophic lateral sclerosis (ALS)|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Human cytomegalovirus infection|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer|Fluid shear stress and atherosclerosis MAPK1IP1L 1271.85302270309 1328.65419823441 1215.05184717177 0.914498180780525 -0.128947794876767 0.391721593904516 1 7.33999 7.02799 7.30563 5.9168 GeneID:93487,Genbank:NM_144578.3,HGNC:HGNC:19840,MIM:617226 mitogen-activated protein kinase 1 interacting protein 1 like GO:0005829,GO:0016020,GO:0042803,GO:0070062 cytosol|membrane|protein homodimerization activity|extracellular exosome MAPK3 1125.34517026381 1021.27087835354 1229.41946217407 1.20381329599459 0.267611656358882 0.0753622892274159 0.94157495521624 17.5118 16.8952 21.1325 22.8013 GeneID:5595,Genbank:NM_001109891.1,HGNC:HGNC:6877,MIM:601795 mitogen-activated protein kinase 3 hsa01521,hsa01522,hsa01524,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04066,hsa04068,hsa04071,hsa04072,hsa04114,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04261,hsa04270,hsa04350,hsa04360,hsa04370,hsa04371,hsa04380,hsa04510,hsa04520,hsa04540,hsa04550,hsa04611,hsa04620,hsa04621,hsa04625,hsa04650,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04713,hsa04720,hsa04722,hsa04723,hsa04724,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa04930,hsa04933,hsa04934,hsa04960,hsa05010,hsa05020,hsa05034,hsa05131,hsa05132,hsa05133,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05167,hsa05170,hsa05200,hsa05203,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Oocyte meiosis|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|TGF-beta signaling pathway|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Focal adhesion|Adherens junction|Gap junction|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Circadian entrainment|Long-term potentiation|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Type II diabetes mellitus|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Aldosterone-regulated sodium reabsorption|Alzheimer disease|Prion diseases|Alcoholism|Shigellosis|Salmonella infection|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer MAPK4 2.53466341630952 3.13253351048394 1.93679332213509 0.618283352964316 -0.693659932761692 0.833296029032968 1 0.0124564 0.00570489 0 0.0110053 GeneID:5596,Genbank:XM_017025839.2,HGNC:HGNC:6878,MIM:176949 mitogen-activated protein kinase 4 hsa04657 IL-17 signaling pathway MAPK6 977.703598761823 1017.54037823491 937.866819288733 0.921699855209298 -0.117631070803152 0.633053077609279 1 9.64484 8.42788 9.77173 7.20493 GeneID:5597,Genbank:NM_002748.3,HGNC:HGNC:6879,MIM:602904 mitogen-activated protein kinase 6 hsa04657 IL-17 signaling pathway MAPK7 668.200615438357 670.521143727 665.880087149714 0.993078433662078 -0.010020428103847 0.940575673974069 1 6.90042 6.91938 6.78722 6.85721 GeneID:5598,Genbank:XM_006721558.3,HGNC:HGNC:6880,MIM:602521 mitogen-activated protein kinase 7 hsa04010,hsa04540,hsa04657,hsa04722,hsa04912,hsa04921,hsa05206,hsa05418 MAPK signaling pathway|Gap junction|IL-17 signaling pathway|Neurotrophin signaling pathway|GnRH signaling pathway|Oxytocin signaling pathway|MicroRNAs in cancer|Fluid shear stress and atherosclerosis MAPK8 628.758150594157 663.321926175093 594.19437501322 0.895785819171572 -0.158774267243411 0.455172747056287 1 4.71097 3.94524 4.08411 3.45921 GeneID:5599,Genbank:NM_001323302.1,HGNC:HGNC:6881,MIM:601158 mitogen-activated protein kinase 8 GO:0001503,GO:0001764,GO:0002102,GO:0004672,GO:0004674,GO:0004705,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006468,GO:0007254,GO:0007258,GO:0009411,GO:0009612,GO:0010468,GO:0010628,GO:0016301,GO:0018105,GO:0018107,GO:0019899,GO:0030424,GO:0031281,GO:0032091,GO:0032880,GO:0034198,GO:0034614,GO:0035033,GO:0042752,GO:0042826,GO:0043005,GO:0043066,GO:0046686,GO:0048263,GO:0048511,GO:0048813,GO:0051247,GO:0051403,GO:0061833,GO:0070301,GO:0071222,GO:0071276,GO:0071310,GO:0071732,GO:0071803,GO:0090045,GO:0097150,GO:0097300,GO:0097441,GO:1902595,GO:2000017,GO:2001235 ossification|neuron migration|podosome|protein kinase activity|protein serine/threonine kinase activity|JUN kinase activity|ATP binding|nucleus|cytoplasm|mitochondrion|cytosol|protein phosphorylation|JNK cascade|JUN phosphorylation|response to UV|response to mechanical stimulus|regulation of gene expression|positive regulation of gene expression|kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|enzyme binding|axon|positive regulation of cyclase activity|negative regulation of protein binding|regulation of protein localization|cellular response to amino acid starvation|cellular response to reactive oxygen species|histone deacetylase regulator activity|regulation of circadian rhythm|histone deacetylase binding|neuron projection|negative regulation of apoptotic process|response to cadmium ion|determination of dorsal identity|rhythmic process|dendrite morphogenesis|positive regulation of protein metabolic process|stress-activated MAPK cascade|protein localization to tricellular tight junction|cellular response to hydrogen peroxide|cellular response to lipopolysaccharide|cellular response to cadmium ion|cellular response to organic substance|cellular response to nitric oxide|positive regulation of podosome assembly|positive regulation of deacetylase activity|neuronal stem cell population maintenance|programmed necrotic cell death|basal dendrite|regulation of DNA replication origin binding|positive regulation of determination of dorsal identity|positive regulation of apoptotic signaling pathway hsa01522,hsa04010,hsa04012,hsa04014,hsa04024,hsa04068,hsa04071,hsa04137,hsa04140,hsa04141,hsa04210,hsa04215,hsa04217,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04664,hsa04668,hsa04722,hsa04723,hsa04728,hsa04750,hsa04910,hsa04912,hsa04914,hsa04917,hsa04920,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa05120,hsa05131,hsa05132,hsa05133,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05164,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05210,hsa05212,hsa05231,hsa05418 Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Necroptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis MAPK8IP1 624.861262611131 602.807080364332 646.915444857931 1.07317160984065 0.101880794519247 0.734550261213405 1 7.16573 9.07131 8.04527 9.67837 GeneID:9479,Genbank:NM_005456.3,HGNC:HGNC:6882,MIM:604641 mitogen-activated protein kinase 8 interacting protein 1 GO:0004860,GO:0005078,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0005886,GO:0006355,GO:0007258,GO:0008432,GO:0016192,GO:0019894,GO:0031434,GO:0031435,GO:0031966,GO:0043508,GO:0044294,GO:0044295,GO:0044297,GO:0044302,GO:0045202,GO:0046328,GO:0048471,GO:2001243 protein kinase inhibitor activity|MAP-kinase scaffold activity|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|regulation of transcription, DNA-templated|JUN phosphorylation|JUN kinase binding|vesicle-mediated transport|kinesin binding|mitogen-activated protein kinase kinase binding|mitogen-activated protein kinase kinase kinase binding|mitochondrial membrane|negative regulation of JUN kinase activity|dendritic growth cone|axonal growth cone|cell body|dentate gyrus mossy fiber|synapse|regulation of JNK cascade|perinuclear region of cytoplasm|negative regulation of intrinsic apoptotic signaling pathway hsa04010 MAPK signaling pathway MAPK8IP2 30.1782212853732 36.1299965750432 24.2264459957032 0.670535518745043 -0.576614340147432 0.278225960131087 1 0.294924 0.23895 0.144615 0.199498 GeneID:23542,Genbank:NM_012324.5,HGNC:HGNC:6883,MIM:607755 mitogen-activated protein kinase 8 interacting protein 2 GO:0000165,GO:0001540,GO:0001662,GO:0005078,GO:0005198,GO:0005622,GO:0005737,GO:0007172,GO:0007254,GO:0007617,GO:0010469,GO:0014069,GO:0019894,GO:0019901,GO:0030295,GO:0032403,GO:0032874,GO:0035176,GO:0043025,GO:0043234,GO:0046328,GO:0046958,GO:0048813,GO:0051966,GO:0060079,GO:2000310,GO:2000311 MAPK cascade|amyloid-beta binding|behavioral fear response|MAP-kinase scaffold activity|structural molecule activity|intracellular|cytoplasm|signal complex assembly|JNK cascade|mating behavior|regulation of receptor activity|postsynaptic density|kinesin binding|protein kinase binding|protein kinase activator activity|protein complex binding|positive regulation of stress-activated MAPK cascade|social behavior|neuronal cell body|protein complex|regulation of JNK cascade|nonassociative learning|dendrite morphogenesis|regulation of synaptic transmission, glutamatergic|excitatory postsynaptic potential|regulation of NMDA receptor activity|regulation of AMPA receptor activity hsa04010 MAPK signaling pathway MAPK8IP3 761.868100705928 771.137634605712 752.598566806143 0.97595880817171 -0.0351078369562603 0.81729284885894 1 3.08364 3.13121 3.05088 3.16363 GeneID:23162,Genbank:XM_024450201.1,HGNC:HGNC:6884,MIM:605431 mitogen-activated protein kinase 8 interacting protein 3 GO:0000139,GO:0005078,GO:0005737,GO:0007257,GO:0008432,GO:0016192,GO:0019894,GO:0030159,GO:0046328 Golgi membrane|MAP-kinase scaffold activity|cytoplasm|activation of JUN kinase activity|JUN kinase binding|vesicle-mediated transport|kinesin binding|receptor signaling complex scaffold activity|regulation of JNK cascade hsa04010 MAPK signaling pathway MAPK9 1017.07800662236 1210.27067537139 823.885337873335 0.680744691777739 -0.554814267233846 0.000289855889496717 0.0450711837493147 6.53946 6.05716 4.65359 4.17197 GeneID:5601,Genbank:NM_002752.4,HGNC:HGNC:6886,MIM:602896 mitogen-activated protein kinase 9 GO:0004705,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0007254,GO:0008134,GO:0009612,GO:0009790,GO:0010468,GO:0010628,GO:0010744,GO:0018105,GO:0034614,GO:0042752,GO:0043005,GO:0043065,GO:0048511,GO:0048666,GO:0061833,GO:0071276,GO:0071310,GO:0071803,GO:2001235 JUN kinase activity|ATP binding|nucleus|cytoplasm|mitochondrion|cytosol|JNK cascade|transcription factor binding|response to mechanical stimulus|embryo development|regulation of gene expression|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|peptidyl-serine phosphorylation|cellular response to reactive oxygen species|regulation of circadian rhythm|neuron projection|positive regulation of apoptotic process|rhythmic process|neuron development|protein localization to tricellular tight junction|cellular response to cadmium ion|cellular response to organic substance|positive regulation of podosome assembly|positive regulation of apoptotic signaling pathway hsa01522,hsa04010,hsa04012,hsa04014,hsa04024,hsa04068,hsa04071,hsa04137,hsa04140,hsa04141,hsa04210,hsa04215,hsa04217,hsa04310,hsa04380,hsa04510,hsa04530,hsa04620,hsa04621,hsa04622,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04664,hsa04668,hsa04722,hsa04723,hsa04728,hsa04750,hsa04910,hsa04912,hsa04914,hsa04917,hsa04920,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa05120,hsa05131,hsa05132,hsa05133,hsa05142,hsa05145,hsa05152,hsa05160,hsa05161,hsa05164,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05210,hsa05212,hsa05231,hsa05418 Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|Autophagy - animal|Protein processing in endoplasmic reticulum|Apoptosis|Apoptosis - multiple species|Necroptosis|Wnt signaling pathway|Osteoclast differentiation|Focal adhesion|Tight junction|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Retrograde endocannabinoid signaling|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Influenza A|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis MAPKAP1 2881.09037374748 2721.24022678819 3040.94052070676 1.11748330440341 0.160253277194425 0.245211771607741 1 17.3348 17.8706 19.659 20.6463 GeneID:79109,Genbank:NM_001006621.1,HGNC:HGNC:18752,MIM:610558 mitogen-activated protein kinase associated protein 1 GO:0005546,GO:0005547,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0017016,GO:0019901,GO:0021762,GO:0030950,GO:0031098,GO:0031410,GO:0031932,GO:0032148,GO:0038203,GO:0043325,GO:0046580,GO:0070300,GO:0080025 phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|Ras GTPase binding|protein kinase binding|substantia nigra development|establishment or maintenance of actin cytoskeleton polarity|stress-activated protein kinase signaling cascade|cytoplasmic vesicle|TORC2 complex|activation of protein kinase B activity|TORC2 signaling|phosphatidylinositol-3,4-bisphosphate binding|negative regulation of Ras protein signal transduction|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding hsa04150 mTOR signaling pathway MAPKAPK2 2821.34874397028 2637.89088783672 3004.80660010384 1.13909434766956 0.187887245973016 0.172398712051129 1 25.0982 25.316 31.5141 27.0243 GeneID:9261,Genbank:XM_005273353.3,HGNC:HGNC:6887,MIM:602006 mitogen-activated protein kinase-activated protein kinase 2 hsa04010,hsa04218,hsa04370,hsa04625,hsa04722,hsa05167,hsa05203 MAPK signaling pathway|Cellular senescence|VEGF signaling pathway|C-type lectin receptor signaling pathway|Neurotrophin signaling pathway|Kaposi sarcoma-associated herpesvirus infection|Viral carcinogenesis MAPKAPK3 1599.20663097832 1538.10475796723 1660.3085039894 1.07945086015056 0.110297569038303 0.452804125121859 1 19.2737 19.8249 21.3004 21.1041 GeneID:7867,Genbank:NM_001243926.1,HGNC:HGNC:6888,MIM:602130 mitogen-activated protein kinase-activated protein kinase 3 GO:0000187,GO:0002224,GO:0004674,GO:0004683,GO:0004708,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006950,GO:0007165,GO:0007166,GO:0007265,GO:0009931,GO:0018105,GO:0032496,GO:0034097,GO:0044351,GO:0046777,GO:0048010,GO:0051019 activation of MAPK activity|toll-like receptor signaling pathway|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|MAP kinase kinase activity|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|response to stress|signal transduction|cell surface receptor signaling pathway|Ras protein signal transduction|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|response to lipopolysaccharide|response to cytokine|macropinocytosis|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|mitogen-activated protein kinase binding hsa04010,hsa04370 MAPK signaling pathway|VEGF signaling pathway MAPKAPK5 763.231753321182 791.287380014903 735.176126627461 0.929088653750064 -0.106111829578415 0.506945121107485 1 1.70414 1.95522 1.65017 1.71754 GeneID:8550,Genbank:XM_017020135.2,HGNC:HGNC:6889,MIM:606723 mitogen-activated protein kinase-activated protein kinase 5 GO:0002039,GO:0004674,GO:0004683,GO:0004708,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006417,GO:0007165,GO:0007166,GO:0007265,GO:0009931,GO:0018105,GO:0032007,GO:0032212,GO:0046777,GO:0051019,GO:0051973,GO:0090400,GO:1901796,GO:1904355 p53 binding|protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|MAP kinase kinase activity|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of translation|signal transduction|cell surface receptor signaling pathway|Ras protein signal transduction|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|negative regulation of TOR signaling|positive regulation of telomere maintenance via telomerase|protein autophosphorylation|mitogen-activated protein kinase binding|positive regulation of telomerase activity|stress-induced premature senescence|regulation of signal transduction by p53 class mediator|positive regulation of telomere capping hsa04010 MAPK signaling pathway MAPKBP1 767.033253135104 807.161769976278 726.90473629393 0.90056883679624 -0.151091539234468 0.340623776491122 1 3.64614 3.62274 3.1955 3.40929 GeneID:23005,Genbank:NM_001128608.1,HGNC:HGNC:29536,MIM:616786 mitogen-activated protein kinase binding protein 1 GO:0003723,GO:0005682,GO:0005737,GO:0008380,GO:0043124,GO:0071011,GO:0071013,GO:0097431,GO:1900425,GO:2000483 RNA binding|U5 snRNP|cytoplasm|RNA splicing|negative regulation of I-kappaB kinase/NF-kappaB signaling|precatalytic spliceosome|catalytic step 2 spliceosome|mitotic spindle pole|negative regulation of defense response to bacterium|negative regulation of interleukin-8 secretion MAPRE1 5096.80513272407 5280.54211751894 4913.0681479292 0.930409802362792 -0.104061798435547 0.447061404492998 1 89.2608 84.1009 80.8612 80.8098 GeneID:22919,Genbank:XM_011528696.2,HGNC:HGNC:6890,MIM:603108 microtubule associated protein RP/EB family member 1 MAPRE2 663.255313613424 662.544714125881 663.965913100967 1.00214506122347 0.00309135480092962 0.981469804856472 1 5.72047 5.49051 6.00863 5.27382 GeneID:10982,Genbank:NM_001143826.2,HGNC:HGNC:6891,MIM:605789 microtubule associated protein RP/EB family member 2 GO:0005737,GO:0007049,GO:0007165,GO:0008017,GO:0008283,GO:0015630,GO:0035371,GO:0042802,GO:0051301 cytoplasm|cell cycle|signal transduction|microtubule binding|cell proliferation|microtubule cytoskeleton|microtubule plus-end|identical protein binding|cell division MAPRE3 547.442917412739 529.844276402478 565.041558423 1.06642948426187 0.0927885732086567 0.602198349754706 1 7.23847 8.20985 7.96361 8.74695 GeneID:22924,Genbank:NM_012326.3,HGNC:HGNC:6892,MIM:605788 microtubule associated protein RP/EB family member 3 GO:0005737,GO:0007049,GO:0008017,GO:0008022,GO:0008104,GO:0015630,GO:0019901,GO:0030496,GO:0035371,GO:0042802,GO:0045737,GO:0045860,GO:0045893,GO:0048471,GO:0051301,GO:1903033 cytoplasm|cell cycle|microtubule binding|protein C-terminus binding|protein localization|microtubule cytoskeleton|protein kinase binding|midbody|microtubule plus-end|identical protein binding|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of protein kinase activity|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm|cell division|positive regulation of microtubule plus-end binding MAPT 134.783183127147 92.2088418062833 177.357524448011 1.92343294822651 0.943683537486257 0.00047080599137591 0.0598446726815602 0.377448 0.438763 0.741457 0.881039 GeneID:4137,Genbank:NM_001123066.3,HGNC:HGNC:6893,MIM:157140 microtubule associated protein tau GO:0000226,GO:0005829,GO:0005874,GO:0005875,GO:0005886,GO:0008017,GO:0030424,GO:0030426,GO:0031116,GO:0031175,GO:0043005,GO:0045298,GO:0045773 microtubule cytoskeleton organization|cytosol|microtubule|microtubule associated complex|plasma membrane|microtubule binding|axon|growth cone|positive regulation of microtubule polymerization|neuron projection development|neuron projection|tubulin complex|positive regulation of axon extension hsa04010,hsa05010 MAPK signaling pathway|Alzheimer disease MARC1 1.78185123348129 2.59443583384164 0.969266633120943 0.373594374729911 -1.42045536256559 0.670799861503385 1 0.0420008 0.0261701 0.0133599 0.0124274 GeneID:64757,Genbank:XM_011509900.3,HGNC:HGNC:26189,MIM:614126 mitochondrial amidoxime reducing component 1 MARC2 187.231143730144 181.601716714661 192.860570745626 1.06199750880469 0.0867803819242404 0.718537810491096 1 2.58796 2.54161 2.48352 3.13812 GeneID:54996,Genbank:NM_001317338.1,HGNC:HGNC:26064,MIM:614127 mitochondrial amidoxime reducing component 2 MARCH1 128.473152117618 122.198232874198 134.748071361039 1.10270065443386 0.141041201648528 0.627698613855539 1 0.554339 0.476829 0.766144 0.49327 GeneID:55016,Genbank:NM_001166373.1,HGNC:HGNC:26077,MIM:613331 membrane associated ring-CH-type finger 1 GO:0000209,GO:0002495,GO:0004842,GO:0005764,GO:0005765,GO:0005768,GO:0005789,GO:0005886,GO:0006955,GO:0008270,GO:0016021,GO:0030659,GO:0031901,GO:0031902,GO:0032588,GO:0042287,GO:0061630 protein polyubiquitination|antigen processing and presentation of peptide antigen via MHC class II|ubiquitin-protein transferase activity|lysosome|lysosomal membrane|endosome|endoplasmic reticulum membrane|plasma membrane|immune response|zinc ion binding|integral component of membrane|cytoplasmic vesicle membrane|early endosome membrane|late endosome membrane|trans-Golgi network membrane|MHC protein binding|ubiquitin protein ligase activity MARCH10 10.7563049976219 13.7602168743831 7.75239312086075 0.563391783111578 -0.827789572265438 0.356567058044753 1 0.0160584 0.0596094 0.0228554 0.0355267 GeneID:162333,Genbank:NM_152598.3,HGNC:HGNC:26655,MIM:613337 membrane associated ring-CH-type finger 10 GO:0008270,GO:0016567,GO:0016740 zinc ion binding|protein ubiquitination|transferase activity MARCH2 476.192224105216 410.115000847428 542.269447363005 1.32223753396609 0.40298137373805 0.0227224513183599 0.612664613324667 6.88012 6.48532 8.69328 9.82845 GeneID:51257,Genbank:XM_011528047.2,HGNC:HGNC:28038,MIM:613332 membrane associated ring-CH-type finger 2 GO:0004842,GO:0005765,GO:0005783,GO:0005789,GO:0006897,GO:0008270,GO:0010008,GO:0016021,GO:0016567,GO:0031410 ubiquitin-protein transferase activity|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|endocytosis|zinc ion binding|endosome membrane|integral component of membrane|protein ubiquitination|cytoplasmic vesicle MARCH3 71.3076535038288 75.7385192384728 66.8767877691849 0.882995712638828 -0.179521661962339 0.629245069277002 1 0.230023 0.23064 0.208105 0.226415 GeneID:115123,Genbank:XM_011543128.2,HGNC:HGNC:28728,MIM:613333 membrane associated ring-CH-type finger 3 GO:0005764,GO:0005768,GO:0006897,GO:0008270,GO:0016021,GO:0016567,GO:0016740,GO:0030659,GO:0031901,GO:0043231 lysosome|endosome|endocytosis|zinc ion binding|integral component of membrane|protein ubiquitination|transferase activity|cytoplasmic vesicle membrane|early endosome membrane|intracellular membrane-bounded organelle MARCH4 4.5544806877409 4.74682654041085 4.36213483507094 0.918958128748767 -0.121928966585986 1 1 0.0668917 0.0167693 0.0444022 0.00831571 GeneID:57574,Genbank:NM_020814.2,HGNC:HGNC:29269,MIM:608208 membrane associated ring-CH-type finger 4 GO:0000139,GO:0004842,GO:0005795,GO:0005802,GO:0008270,GO:0016021 Golgi membrane|ubiquitin-protein transferase activity|Golgi stack|trans-Golgi network|zinc ion binding|integral component of membrane MARCH5 1313.5650666334 1261.42039761859 1365.70973564821 1.08267611513696 0.114601722197638 0.436582871589571 1 13.7502 14.5803 16.1303 14.7802 GeneID:54708,Genbank:NM_017824.4,HGNC:HGNC:26025,MIM:610637 membrane associated ring-CH-type finger 5 GO:0000209,GO:0004842,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0008270,GO:0016020,GO:0016021,GO:0051020,GO:0051865,GO:0070585,GO:0090140,GO:0090141,GO:0090344 protein polyubiquitination|ubiquitin-protein transferase activity|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|membrane|integral component of membrane|GTPase binding|protein autoubiquitination|protein localization to mitochondrion|regulation of mitochondrial fission|positive regulation of mitochondrial fission|negative regulation of cell aging MARCH6 2451.98026863337 2500.98847890209 2402.97205836464 0.960808927604305 -0.0576785386079495 0.687668830505052 1 7.90796 8.06739 8.77776 6.88063 GeneID:10299,Genbank:NM_005885.3,HGNC:HGNC:30550,MIM:613297 membrane associated ring-CH-type finger 6 GO:0000835,GO:0004842,GO:0005783,GO:0005789,GO:0008270,GO:0010498,GO:0016020,GO:0016021,GO:0019899,GO:0030176,GO:0031624,GO:0036503,GO:0044322,GO:0070936,GO:1904264,GO:1904380,GO:1990381 ER ubiquitin ligase complex|ubiquitin-protein transferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|proteasomal protein catabolic process|membrane|integral component of membrane|enzyme binding|integral component of endoplasmic reticulum membrane|ubiquitin conjugating enzyme binding|ERAD pathway|endoplasmic reticulum quality control compartment|protein K48-linked ubiquitination|ubiquitin protein ligase activity involved in ERAD pathway|endoplasmic reticulum mannose trimming|ubiquitin-specific protease binding hsa04141 Protein processing in endoplasmic reticulum MARCH7 493.319107214784 539.259460242436 447.378754187133 0.829616886064464 -0.26948283574884 0.367067999656246 1 5.78774 4.71817 5.24545 3.45603 GeneID:64844,Genbank:NM_001282805.1,HGNC:HGNC:17393,MIM:613334 membrane associated ring-CH-type finger 7 GO:0002643,GO:0008270,GO:0016567,GO:0016740,GO:0042130 regulation of tolerance induction|zinc ion binding|protein ubiquitination|transferase activity|negative regulation of T cell proliferation MARCH8 560.301511850134 580.25297021833 540.350053481938 0.931231861301152 -0.102787675220619 0.549345212904802 1 3.59255 3.59329 3.26061 3.34618 GeneID:220972,Genbank:NM_145021.5,HGNC:HGNC:23356,MIM:613335 membrane associated ring-CH-type finger 8 GO:0000209,GO:0002250,GO:0004842,GO:0005764,GO:0005765,GO:0005768,GO:0008270,GO:0016021,GO:0030659,GO:0031901 protein polyubiquitination|adaptive immune response|ubiquitin-protein transferase activity|lysosome|lysosomal membrane|endosome|zinc ion binding|integral component of membrane|cytoplasmic vesicle membrane|early endosome membrane MARCH9 456.369539837768 485.796702156963 426.942377518574 0.878849888488183 -0.186311327274968 0.281575769580469 1 6.83859 8.0664 6.4084 6.68933 GeneID:92979,Genbank:NM_138396.5,HGNC:HGNC:25139,MIM:613336 membrane associated ring-CH-type finger 9 GO:0000139,GO:0005765,GO:0005795,GO:0005802,GO:0008270,GO:0016021,GO:0016567,GO:0016740 Golgi membrane|lysosomal membrane|Golgi stack|trans-Golgi network|zinc ion binding|integral component of membrane|protein ubiquitination|transferase activity MARCKS 11322.8657299185 10842.4704466548 11803.2610131821 1.08861362096899 0.122491992600841 0.33899782685911 1 142.264 140.879 153.776 156.881 GeneID:4082,Genbank:NM_002356.6,HGNC:HGNC:6759,MIM:177061 myristoylated alanine rich protein kinase C substrate hsa04666,hsa05206 Fc gamma R-mediated phagocytosis|MicroRNAs in cancer MARCKSL1 1441.36403385941 1535.07808566123 1347.6499820576 0.877903211990094 -0.187866202141504 0.190391047768897 1 46.02 47.9046 38.8986 44.3819 GeneID:65108,Genbank:NM_023009.6,HGNC:HGNC:7142,MIM:602940 MARCKS like 1 hsa04666,hsa05140 Fc gamma R-mediated phagocytosis|Leishmaniasis MARF1 802.871588982229 776.941039189192 828.802138775265 1.06675036710661 0.0932226070216127 0.566793782623392 1 3.71943 3.8107 4.63758 3.39761 GeneID:9665,Genbank:NM_001184999.1,HGNC:HGNC:29562,MIM:614593 meiosis regulator and mRNA stability factor 1 GO:0003723,GO:0005777,GO:0005794,GO:0006302,GO:0007143,GO:0010468,GO:0010923,GO:0016020,GO:0043231,GO:0048477 RNA binding|peroxisome|Golgi apparatus|double-strand break repair|female meiotic nuclear division|regulation of gene expression|negative regulation of phosphatase activity|membrane|intracellular membrane-bounded organelle|oogenesis MARK1 292.327013871293 293.374179978807 291.279847763778 0.992861225159007 -0.0103360123463758 0.977714694561868 1 1.17828 1.18862 1.3896 1.19765 GeneID:4139,Genbank:NM_001286124.1,HGNC:HGNC:6896,MIM:606511 microtubule affinity regulating kinase 1 GO:0000226,GO:0000287,GO:0001764,GO:0001786,GO:0004674,GO:0005524,GO:0005546,GO:0005737,GO:0005856,GO:0005886,GO:0006468,GO:0007010,GO:0015630,GO:0016055,GO:0030010,GO:0035556,GO:0050321,GO:0070300 microtubule cytoskeleton organization|magnesium ion binding|neuron migration|phosphatidylserine binding|protein serine/threonine kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytoskeleton|plasma membrane|protein phosphorylation|cytoskeleton organization|microtubule cytoskeleton|Wnt signaling pathway|establishment of cell polarity|intracellular signal transduction|tau-protein kinase activity|phosphatidic acid binding MARK2 1148.58190747665 1102.06501609161 1195.0987988617 1.08441768989277 0.116920552881041 0.453707782178063 1 7.59583 8.04203 8.90101 8.59274 GeneID:2011,Genbank:NM_001039469.2,HGNC:HGNC:3332,MIM:600526 microtubule affinity regulating kinase 2 GO:0000226,GO:0000287,GO:0000422,GO:0001764,GO:0003723,GO:0004674,GO:0005524,GO:0005654,GO:0005739,GO:0005884,GO:0005886,GO:0006468,GO:0008289,GO:0010976,GO:0016020,GO:0016055,GO:0016328,GO:0018107,GO:0030010,GO:0030295,GO:0032147,GO:0035556,GO:0045197,GO:0045296,GO:0046777,GO:0050321,GO:0050770,GO:0051493,GO:0051646,GO:0097427 microtubule cytoskeleton organization|magnesium ion binding|autophagy of mitochondrion|neuron migration|RNA binding|protein serine/threonine kinase activity|ATP binding|nucleoplasm|mitochondrion|actin filament|plasma membrane|protein phosphorylation|lipid binding|positive regulation of neuron projection development|membrane|Wnt signaling pathway|lateral plasma membrane|peptidyl-threonine phosphorylation|establishment of cell polarity|protein kinase activator activity|activation of protein kinase activity|intracellular signal transduction|establishment or maintenance of epithelial cell apical/basal polarity|cadherin binding|protein autophosphorylation|tau-protein kinase activity|regulation of axonogenesis|regulation of cytoskeleton organization|mitochondrion localization|microtubule bundle MARK3 1306.95043788496 1331.48978244253 1282.41109332739 0.963140018224463 -0.0541825471674995 0.713332012772905 1 11.3307 11.3383 11.9765 9.78003 GeneID:4140,Genbank:NM_001128918.2,HGNC:HGNC:6897,MIM:602678 microtubule affinity regulating kinase 3 GO:0000165,GO:0000226,GO:0004674,GO:0005524,GO:0005829,GO:0005886,GO:0030010,GO:0035331,GO:0070062 MAPK cascade|microtubule cytoskeleton organization|protein serine/threonine kinase activity|ATP binding|cytosol|plasma membrane|establishment of cell polarity|negative regulation of hippo signaling|extracellular exosome MARK4 845.368531490117 766.073224451868 924.663838528365 1.20701756570329 0.27144667175874 0.0842844226715807 0.963678922522777 5.06702 4.96812 6.20744 6.24768 GeneID:57787,Genbank:NM_031417.3,HGNC:HGNC:13538,MIM:606495 microtubule affinity regulating kinase 4 MARS 5072.17734343761 5199.58261099834 4944.77207587689 0.95099404044808 -0.072491794645835 0.593105448164726 1 66.2761 68.1324 60.7138 68.6016 GeneID:4141,Genbank:NM_004990.3,HGNC:HGNC:6898,MIM:156560 methionyl-tRNA synthetase GO:0000049,GO:0004825,GO:0005524,GO:0005730,GO:0005737,GO:0005829,GO:0006418,GO:0006431,GO:0009267,GO:0009303,GO:0016020,GO:0017101,GO:0032869,GO:0036120,GO:0070062,GO:0071364,GO:1901838 tRNA binding|methionine-tRNA ligase activity|ATP binding|nucleolus|cytoplasm|cytosol|tRNA aminoacylation for protein translation|methionyl-tRNA aminoacylation|cellular response to starvation|rRNA transcription|membrane|aminoacyl-tRNA synthetase multienzyme complex|cellular response to insulin stimulus|cellular response to platelet-derived growth factor stimulus|extracellular exosome|cellular response to epidermal growth factor stimulus|positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter hsa00450,hsa00970 Selenocompound metabolism|Aminoacyl-tRNA biosynthesis MARS2 373.03379498424 403.907768756253 342.159821212227 0.84712364475146 -0.239355536603815 0.197596422896594 1 7.16778 7.82604 6.8745 6.03522 GeneID:92935,Genbank:NM_138395.3,HGNC:HGNC:25133,MIM:609728 methionyl-tRNA synthetase 2, mitochondrial GO:0004825,GO:0005524,GO:0005759,GO:0006418,GO:0006431 methionine-tRNA ligase activity|ATP binding|mitochondrial matrix|tRNA aminoacylation for protein translation|methionyl-tRNA aminoacylation hsa00450,hsa00970 Selenocompound metabolism|Aminoacyl-tRNA biosynthesis MARVELD1 1438.70091187665 1193.33193271355 1684.06989103974 1.41123340863785 0.496956619852772 0.000715559195537253 0.0801426299001724 19.1368 20.7558 29.1336 28.3262 GeneID:83742,Genbank:NM_031484.3,HGNC:HGNC:28674,MIM:616970 MARVEL domain containing 1 GO:0001766,GO:0005634,GO:0005737,GO:0005856,GO:0005886,GO:0007049,GO:0008104,GO:0016021,GO:0019911,GO:0042552,GO:0045121 membrane raft polarization|nucleus|cytoplasm|cytoskeleton|plasma membrane|cell cycle|protein localization|integral component of membrane|structural constituent of myelin sheath|myelination|membrane raft MARVELD2 1.26776669418146 1.56626675524197 0.969266633120943 0.61883879605885 -0.692364450254232 0.974556248291384 1 0.0191903 0.00887633 0.00912128 0.0084954 GeneID:153562,Genbank:NM_001038603.2,HGNC:HGNC:26401,MIM:610572 MARVEL domain containing 2 GO:0005737,GO:0005923,GO:0007605,GO:0016021,GO:0016323,GO:0016324,GO:0030054,GO:0031410,GO:0045216,GO:0061028,GO:0061689,GO:0070830 cytoplasm|bicellular tight junction|sensory perception of sound|integral component of membrane|basolateral plasma membrane|apical plasma membrane|cell junction|cytoplasmic vesicle|cell-cell junction organization|establishment of endothelial barrier|tricellular tight junction|bicellular tight junction assembly hsa04530 Tight junction MARVELD3 2.34396204746607 3.71865746181119 0.969266633120943 0.260649614296246 -1.93981636982129 0.44644484640269 1 0.0314858 0.00720562 0.00742954 0 GeneID:91862,Genbank:NM_001017967.3,HGNC:HGNC:30525,MIM:614094 MARVEL domain containing 3 GO:0005923,GO:0006970,GO:0010633,GO:0016021,GO:0031410,GO:0031435,GO:0045216,GO:0046329,GO:0050680,GO:0070830,GO:1902414 bicellular tight junction|response to osmotic stress|negative regulation of epithelial cell migration|integral component of membrane|cytoplasmic vesicle|mitogen-activated protein kinase kinase kinase binding|cell-cell junction organization|negative regulation of JNK cascade|negative regulation of epithelial cell proliferation|bicellular tight junction assembly|protein localization to cell junction hsa04530 Tight junction MASP1 1.26526514449636 1.07619535328461 1.45433493570811 1.35136704620532 0.434419579785585 1 1 0.00632489 0 0.00600014 0.00279994 GeneID:5648,Genbank:NM_001879.5,HGNC:HGNC:6901,MIM:600521 mannan binding lectin serine peptidase 1 GO:0001867,GO:0004252,GO:0005509,GO:0005576,GO:0005615,GO:0005654,GO:0005829,GO:0006898,GO:0006956,GO:0008233,GO:0042803,GO:0045916,GO:0048306 complement activation, lectin pathway|serine-type endopeptidase activity|calcium ion binding|extracellular region|extracellular space|nucleoplasm|cytosol|receptor-mediated endocytosis|complement activation|peptidase activity|protein homodimerization activity|negative regulation of complement activation|calcium-dependent protein binding hsa04610,hsa05150 Complement and coagulation cascades|Staphylococcus aureus infection MASP2 3.97542639944224 5.04479284362845 2.90605995525603 0.576051395039219 -0.795730560892671 0.648579973731045 1 0.0315931 0.0142617 0 0.0138261 GeneID:10747,Genbank:NM_006610.3,HGNC:HGNC:6902,MIM:605102 mannan binding lectin serine peptidase 2 hsa04610,hsa05150 Complement and coagulation cascades|Staphylococcus aureus infection MAST1 111.450296855299 109.03394860625 113.866645104349 1.04432286053908 0.062567801266044 0.855042493496921 1 0.815846 0.696228 0.57135 0.789672 GeneID:22983,Genbank:XM_011527805.2,HGNC:HGNC:19034,MIM:612256 microtubule associated serine/threonine kinase 1 GO:0000287,GO:0004674,GO:0005524,GO:0005622,GO:0005737,GO:0005856,GO:0005886,GO:0006468,GO:0007010,GO:0018105,GO:0035556 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|intracellular|cytoplasm|cytoskeleton|plasma membrane|protein phosphorylation|cytoskeleton organization|peptidyl-serine phosphorylation|intracellular signal transduction MAST2 2321.51836440344 2283.81651460096 2359.22021420592 1.03301653137321 0.0468633418499309 0.747553095047373 1 9.72377 9.97351 10.6301 9.86545 GeneID:23139,Genbank:XM_011541065.1,HGNC:HGNC:19035,MIM:612257 microtubule associated serine/threonine kinase 2 GO:0000287,GO:0004674,GO:0005524,GO:0005737,GO:0005886,GO:0006468,GO:0007010,GO:0008017,GO:0015630,GO:0018105,GO:0019902,GO:0035556,GO:0045075,GO:0048515 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|cytoplasm|plasma membrane|protein phosphorylation|cytoskeleton organization|microtubule binding|microtubule cytoskeleton|peptidyl-serine phosphorylation|phosphatase binding|intracellular signal transduction|regulation of interleukin-12 biosynthetic process|spermatid differentiation MAST3 199.422664633823 223.910536416411 174.934792851236 0.781270929233567 -0.356105161781067 0.117491019625359 1 1.30524 1.22299 0.938658 1.12963 GeneID:23031,Genbank:XM_011527823.1,HGNC:HGNC:19036,MIM:612258 microtubule associated serine/threonine kinase 3 GO:0000287,GO:0004674,GO:0005524,GO:0005622,GO:0007010,GO:0018105,GO:0035556 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|intracellular|cytoskeleton organization|peptidyl-serine phosphorylation|intracellular signal transduction MAST4 245.723836473035 245.213929418894 246.233743527176 1.00415887511243 0.00598754638383425 1 1 0.282878 0.316204 0.377608 0.239774 GeneID:375449,Genbank:NM_001164664.1,HGNC:HGNC:19037 microtubule associated serine/threonine kinase family member 4 GO:0000287,GO:0004674,GO:0005524,GO:0005622,GO:0005737,GO:0018105,GO:0035556 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|intracellular|cytoplasm|peptidyl-serine phosphorylation|intracellular signal transduction MASTL 710.976076359886 741.414749873983 680.53740284579 0.9178902941457 -0.123606361237261 0.704769969504128 1 5.03369 4.12076 5.15538 3.27472 GeneID:84930,Genbank:XM_006717519.4,HGNC:HGNC:19042,MIM:608221 microtubule associated serine/threonine kinase like GO:0000086,GO:0000278,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006974,GO:0007147,GO:0016301,GO:0018105,GO:0032154,GO:0032515,GO:0035556,GO:0051301,GO:0051441,GO:0051721,GO:0051726 G2/M transition of mitotic cell cycle|mitotic cell cycle|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cellular response to DNA damage stimulus|female meiosis II|kinase activity|peptidyl-serine phosphorylation|cleavage furrow|negative regulation of phosphoprotein phosphatase activity|intracellular signal transduction|cell division|positive regulation of ubiquitin-protein ligase activity involved in meiotic cell cycle|protein phosphatase 2A binding|regulation of cell cycle MAT2A 6261.35604466893 6526.49500368642 5996.21708565145 0.918749969511132 -0.122255797927068 0.356511815687507 1 102.103 102.437 96.0433 94.8528 GeneID:4144,Genbank:NM_005911.5,HGNC:HGNC:6904,MIM:601468 methionine adenosyltransferase 2A GO:0004478,GO:0005524,GO:0005829,GO:0006556,GO:0006730,GO:0032259,GO:0034214,GO:0042802,GO:0046872,GO:0048269,GO:0051291,GO:1990830 methionine adenosyltransferase activity|ATP binding|cytosol|S-adenosylmethionine biosynthetic process|one-carbon metabolic process|methylation|protein hexamerization|identical protein binding|metal ion binding|methionine adenosyltransferase complex|protein heterooligomerization|cellular response to leukemia inhibitory factor hsa00270 Cysteine and methionine metabolism MAT2B 1537.07207945976 1667.31584394629 1406.82831497323 0.843768335844202 -0.245081146436146 0.0928505478864514 0.987898138646211 30.9019 30.1779 25.6749 25.8161 GeneID:27430,Genbank:NM_182796.2,HGNC:HGNC:6905,MIM:605527 methionine adenosyltransferase 2B GO:0005622,GO:0005634,GO:0005739,GO:0005829,GO:0006556,GO:0006730,GO:0019899,GO:0032259,GO:0048269,GO:0048270,GO:0070062 intracellular|nucleus|mitochondrion|cytosol|S-adenosylmethionine biosynthetic process|one-carbon metabolic process|enzyme binding|methylation|methionine adenosyltransferase complex|methionine adenosyltransferase regulator activity|extracellular exosome hsa00270 Cysteine and methionine metabolism MATK 1.99743571172061 2.05633815719933 1.93853326624189 0.942711323745559 -0.0851120372001571 1 1 0.042218 0.0356117 0.0386475 0.0179961 GeneID:4145,Genbank:NM_002378.3,HGNC:HGNC:6906,MIM:600038 megakaryocyte-associated tyrosine kinase GO:0004713,GO:0004715,GO:0005102,GO:0005524,GO:0005829,GO:0006468,GO:0007169,GO:0007498,GO:0008283,GO:0008284,GO:0030154,GO:0031234,GO:0038083,GO:0038128,GO:0045087 protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|receptor binding|ATP binding|cytosol|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|mesoderm development|cell proliferation|positive regulation of cell proliferation|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|ERBB2 signaling pathway|innate immune response hsa04722 Neurotrophin signaling pathway MATN1 9.60610244046775 11.9440100906085 7.26819479032697 0.608522157565984 -0.716618299444546 0.480506073552878 1 0.138251 0.0722026 0.0650884 0.0606712 GeneID:4146,Genbank:NM_002379.3,HGNC:HGNC:6907,MIM:115437 matrilin 1 GO:0003429,GO:0005201,GO:0005509,GO:0005576,GO:0005578,GO:0006461,GO:0030198,GO:0030500 growth plate cartilage chondrocyte morphogenesis|extracellular matrix structural constituent|calcium ion binding|extracellular region|proteinaceous extracellular matrix|protein complex assembly|extracellular matrix organization|regulation of bone mineralization MATN2 271.813811272984 305.174111245361 238.453511300606 0.781368741691489 -0.355924552583962 0.0861767696837297 0.964561165794104 2.466 2.39126 2.06494 1.69243 GeneID:4147,Genbank:NM_002380.4,HGNC:HGNC:6908,MIM:602108 matrilin 2 GO:0001764,GO:0005509,GO:0005578,GO:0005604,GO:0005615,GO:0007411,GO:0008347,GO:0031012,GO:0031104,GO:0048678 neuron migration|calcium ion binding|proteinaceous extracellular matrix|basement membrane|extracellular space|axon guidance|glial cell migration|extracellular matrix|dendrite regeneration|response to axon injury MATN3 4.23240247536461 3.13253351048394 5.33227144024528 1.70222327148274 0.76742027999397 0.650150728555276 1 0.0544791 0.0340639 0.121823 0.0647447 GeneID:4148,Genbank:NM_002381.4,HGNC:HGNC:6909,MIM:602109 matrilin 3 GO:0001501,GO:0005201,GO:0005509,GO:0005576,GO:0005578,GO:0005788,GO:0030198,GO:0043687,GO:0044267 skeletal system development|extracellular matrix structural constituent|calcium ion binding|extracellular region|proteinaceous extracellular matrix|endoplasmic reticulum lumen|extracellular matrix organization|post-translational protein modification|cellular protein metabolic process MATN4 2.02188383508978 2.10436443188427 1.93940323829528 0.921609968744205 -0.117771772877052 1 1 0.0851958 0.0239943 0.0783344 0.024401 GeneID:8785,Genbank:XM_017028115.1,HGNC:HGNC:6910,MIM:603897 matrilin 4 GO:0005509,GO:0005576,GO:0030198 calcium ion binding|extracellular region|extracellular matrix organization MATR3 2696.28328103467 2862.00501065525 2530.56155141408 0.884191866189192 -0.17756863209786 0.529798160403718 1 19.3423 15.544 18.4739 13.127 GeneID:9782,Genbank:NM_199189.2,HGNC:HGNC:6912,MIM:164015 matrin 3 GO:0002218,GO:0003723,GO:0005198,GO:0005637,GO:0008270,GO:0010608,GO:0016020,GO:0016363,GO:0035198,GO:0042802,GO:0045087 activation of innate immune response|RNA binding|structural molecule activity|nuclear inner membrane|zinc ion binding|posttranscriptional regulation of gene expression|membrane|nuclear matrix|miRNA binding|identical protein binding|innate immune response MAU2 1462.8545630226 1478.07591555501 1447.63321049018 0.979403828487798 -0.0300242593373505 0.839384582638254 1 9.99939 9.53649 10.2987 9.06796 GeneID:23383,Genbank:XM_017026539.2,HGNC:HGNC:29140,MIM:614560 MAU2 sister chromatid cohesion factor GO:0000785,GO:0003690,GO:0005634,GO:0005654,GO:0016604,GO:0032116,GO:0034088,GO:0047485,GO:0051301,GO:0071921,GO:0090694 chromatin|double-stranded DNA binding|nucleus|nucleoplasm|nuclear body|SMC loading complex|maintenance of mitotic sister chromatid cohesion|protein N-terminus binding|cell division|cohesin loading|Scc2-Scc4 cohesin loading complex MAVS 3834.14861640216 3938.69929405553 3729.59793874879 0.94691106385747 -0.0786991641853373 0.55353424236997 1 12.8588 13.1914 12.4206 12.6291 GeneID:57506,Genbank:NM_020746.4,HGNC:HGNC:29233,MIM:609676 mitochondrial antiviral signaling protein GO:0001934,GO:0002218,GO:0002230,GO:0004871,GO:0005739,GO:0005741,GO:0005778,GO:0007165,GO:0016021,GO:0016032,GO:0016579,GO:0019901,GO:0031966,GO:0032480,GO:0032727,GO:0032728,GO:0032757,GO:0032760,GO:0033160,GO:0035549,GO:0042742,GO:0042993,GO:0043123,GO:0045071,GO:0045087,GO:0045944,GO:0050700,GO:0051091,GO:0051607,GO:0060340,GO:0060760,GO:0071360,GO:0071651,GO:0071660,GO:1900063,GO:1902741,GO:1904469,GO:2000778 positive regulation of protein phosphorylation|activation of innate immune response|positive regulation of defense response to virus by host|signal transducer activity|mitochondrion|mitochondrial outer membrane|peroxisomal membrane|signal transduction|integral component of membrane|viral process|protein deubiquitination|protein kinase binding|mitochondrial membrane|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|positive regulation of protein import into nucleus, translocation|positive regulation of interferon-beta secretion|defense response to bacterium|positive regulation of transcription factor import into nucleus|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|innate immune response|positive regulation of transcription from RNA polymerase II promoter|CARD domain binding|positive regulation of DNA binding transcription factor activity|defense response to virus|positive regulation of type I interferon-mediated signaling pathway|positive regulation of response to cytokine stimulus|cellular response to exogenous dsRNA|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of IP-10 production|regulation of peroxisome organization|positive regulation of interferon-alpha secretion|positive regulation of tumor necrosis factor secretion|positive regulation of interleukin-6 secretion hsa04621,hsa04622,hsa04623,hsa05160,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169 NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Herpes simplex infection|Epstein-Barr virus infection MAX 731.800329504078 749.275509615516 714.32514939264 0.953354460709905 -0.0689153816646955 0.693622048830235 1 8.53699 7.77458 7.60973 7.76973 GeneID:4149,Genbank:NM_001271069.1,HGNC:HGNC:6913,MIM:154950 MYC associated factor X GO:0000122,GO:0000790,GO:0000978,GO:0000983,GO:0001078,GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0006357,GO:0006461,GO:0009267,GO:0010243,GO:0010629,GO:0016605,GO:0030425,GO:0032403,GO:0032868,GO:0032993,GO:0042803,GO:0043565,GO:0045944,GO:0046982,GO:0048678,GO:0051402,GO:0060041,GO:0070888,GO:0071339,GO:0071375,GO:0090575 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|protein complex assembly|cellular response to starvation|response to organonitrogen compound|negative regulation of gene expression|PML body|dendrite|protein complex binding|response to insulin|protein-DNA complex|protein homodimerization activity|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|response to axon injury|neuron apoptotic process|retina development in camera-type eye|E-box binding|MLL1 complex|cellular response to peptide hormone stimulus|RNA polymerase II transcription factor complex hsa04010,hsa05200,hsa05202,hsa05222 MAPK signaling pathway|Pathways in cancer|Transcriptional misregulation in cancer|Small cell lung cancer MAZ 7718.79740422684 6791.79037928218 8645.8044291715 1.27297869138377 0.348208269913064 0.00860093170411653 0.362097302226572 113.871 118.199 155.047 145.563 GeneID:4150,Genbank:XM_006721047.4,HGNC:HGNC:6914,MIM:600999 MYC associated zinc finger protein GO:0000979,GO:0003723,GO:0005634,GO:0006355,GO:0006367,GO:0006369,GO:0046872 RNA polymerase II core promoter sequence-specific DNA binding|RNA binding|nucleus|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|termination of RNA polymerase II transcription|metal ion binding MB 2.02982347017177 3.57457863775636 0.48506830258717 0.135699435302291 -2.88151337772882 0.310086678524488 1 0.0600547 0.0269487 0 0 GeneID:4151,Genbank:NM_203377.1,HGNC:HGNC:6915,MIM:160000 myoglobin MB21D2 297.528766428787 315.417584411781 279.639948445793 0.886570572681578 -0.173692617959337 0.388187630687553 1 4.6014 4.75071 4.4287 3.92354 GeneID:151963,Genbank:NM_178496.3,HGNC:HGNC:30438 Mab-21 domain containing 2 GO:0032403,GO:0045296 protein complex binding|cadherin binding MBD1 641.301429974836 639.503583580486 643.099276369185 1.0056226311799 0.00808902257553773 0.996622999880508 1 2.91826 3.38186 3.14117 2.98345 GeneID:4152,Genbank:NM_001204141.1,HGNC:HGNC:6916,MIM:156535 methyl-CpG binding domain protein 1 GO:0003677,GO:0005634,GO:0005694,GO:0006366,GO:0008270,GO:0008327,GO:0010385,GO:0016363,GO:0016607,GO:0045892 DNA binding|nucleus|chromosome|transcription from RNA polymerase II promoter|zinc ion binding|methyl-CpG binding|double-stranded methylated DNA binding|nuclear matrix|nuclear speck|negative regulation of transcription, DNA-templated MBD2 691.793711178291 713.78068026734 669.806742089241 0.938392927416264 -0.0917359549437182 0.572807869415884 1 4.53164 4.49679 4.75884 3.99366 GeneID:8932,Genbank:NM_003927.4,HGNC:HGNC:6917,MIM:603547 methyl-CpG binding domain protein 2 MBD3 5977.89463298401 5964.00739280412 5991.78187316389 1.00465701642042 0.00670305845485216 0.984835595700369 1 104.213 106.139 106.618 108.057 GeneID:53615,Genbank:NM_001281454.1,HGNC:HGNC:6918,MIM:603573 methyl-CpG binding domain protein 3 GO:0000122,GO:0000790,GO:0000792,GO:0001701,GO:0003677,GO:0003682,GO:0004407,GO:0005654,GO:0005737,GO:0006346,GO:0006351,GO:0007420,GO:0007507,GO:0007568,GO:0008327,GO:0009888,GO:0016573,GO:0016581,GO:0031667,GO:0032355,GO:0043044,GO:0043234,GO:0044030,GO:0048568,GO:1901796 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|heterochromatin|in utero embryonic development|DNA binding|chromatin binding|histone deacetylase activity|nucleoplasm|cytoplasm|methylation-dependent chromatin silencing|transcription, DNA-templated|brain development|heart development|aging|methyl-CpG binding|tissue development|histone acetylation|NuRD complex|response to nutrient levels|response to estradiol|ATP-dependent chromatin remodeling|protein complex|regulation of DNA methylation|embryonic organ development|regulation of signal transduction by p53 class mediator MBD4 463.896318871902 501.784727976214 426.007909767589 0.848985403533012 -0.236188344915365 0.193192817989381 1 4.63456 4.02843 4.04836 3.54764 GeneID:8930,Genbank:NM_001276273.1,HGNC:HGNC:6919,MIM:603574 methyl-CpG binding domain 4, DNA glycosylase hsa03410 Base excision repair MBD5 170.043793106932 166.573199388254 173.51438682561 1.04167049358989 0.058898989283665 0.823422673716557 1 0.424484 0.455993 0.532256 0.388523 GeneID:55777,Genbank:XM_011511472.2,HGNC:HGNC:20444,MIM:611472 methyl-CpG binding domain protein 5 GO:0003682,GO:0005634,GO:0005654,GO:0007399,GO:0007610,GO:0010369,GO:0016579,GO:0030496,GO:0040014,GO:0042593,GO:0060399,GO:0070062 chromatin binding|nucleus|nucleoplasm|nervous system development|behavior|chromocenter|protein deubiquitination|midbody|regulation of multicellular organism growth|glucose homeostasis|positive regulation of growth hormone receptor signaling pathway|extracellular exosome MBD6 643.048297691871 537.339426255893 748.757169127848 1.39345287641572 0.478664214418124 0.00402949421605249 0.249175209900759 3.58792 4.07196 5.87612 5.32796 GeneID:114785,Genbank:XM_006719217.1,HGNC:HGNC:20445 methyl-CpG binding domain protein 6 GO:0001650,GO:0003682,GO:0005634,GO:0005654,GO:0010369,GO:0016579 fibrillar center|chromatin binding|nucleus|nucleoplasm|chromocenter|protein deubiquitination MBIP 268.02153175996 283.044462918126 252.998600601794 0.893847553113863 -0.161899296052161 0.443500273959559 1 5.24119 5.2416 5.12026 3.96762 GeneID:51562,Genbank:XM_017021367.2,HGNC:HGNC:20427,MIM:609431 MAP3K12 binding inhibitory protein 1 GO:0000173,GO:0004860,GO:0005634,GO:0005671,GO:0005730,GO:0005829,GO:0030366,GO:0032324,GO:0042802,GO:0043966 inactivation of MAPK activity involved in osmosensory signaling pathway|protein kinase inhibitor activity|nucleus|Ada2/Gcn5/Ada3 transcription activator complex|nucleolus|cytosol|molybdopterin synthase activity|molybdopterin cofactor biosynthetic process|identical protein binding|histone H3 acetylation MBLAC1 74.8160399885917 74.0379823142839 75.5940976628996 1.02101779789203 0.0300080148021799 0.966801665769354 1 2.14995 2.49002 2.44796 2.60162 GeneID:255374,Genbank:NM_203397.2,HGNC:HGNC:22180 metallo-beta-lactamase domain containing 1 GO:0016787,GO:0046872 hydrolase activity|metal ion binding MBLAC2 105.159586285564 127.435130816566 82.8840417545615 0.65040182580318 -0.620596787545922 0.0359020844480767 0.738653561785664 1.64645 1.3302 1.18532 0.779709 GeneID:153364,Genbank:NM_203406.1,HGNC:HGNC:33711 metallo-beta-lactamase domain containing 2 GO:0016787,GO:0046872,GO:0070062 hydrolase activity|metal ion binding|extracellular exosome MBNL1 920.293512541894 959.828639664384 880.758385419403 0.917620447049143 -0.124030556053524 0.735339143071028 1 5.34189 4.49076 5.86077 3.56504 GeneID:4154,Genbank:XM_005247475.3,HGNC:HGNC:6923,MIM:606516 muscleblind like splicing regulator 1 GO:0001069,GO:0001701,GO:0003723,GO:0003725,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0007399,GO:0008380,GO:0010494,GO:0030326,GO:0043484,GO:0045445,GO:0046872 regulatory region RNA binding|in utero embryonic development|RNA binding|double-stranded RNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|nervous system development|RNA splicing|cytoplasmic stress granule|embryonic limb morphogenesis|regulation of RNA splicing|myoblast differentiation|metal ion binding MBNL2 269.255273106219 292.748821407048 245.76172480539 0.839496888917184 -0.252403116183743 0.573411783124551 1 1.85922 1.36703 1.70391 1.01657 GeneID:10150,Genbank:NM_001306070.1,HGNC:HGNC:16746,MIM:607327 muscleblind like splicing regulator 2 GO:0000381,GO:0003723,GO:0005654,GO:0005737,GO:0006397,GO:0008380,GO:0043484,GO:0046872 regulation of alternative mRNA splicing, via spliceosome|RNA binding|nucleoplasm|cytoplasm|mRNA processing|RNA splicing|regulation of RNA splicing|metal ion binding MBNL3 96.3213302435013 99.5687044898969 93.0739559971057 0.934771186126558 -0.097314830463885 0.890813678416311 1 0.318962 0.221699 0.347006 0.158753 GeneID:55796,Genbank:NM_001170704.1,HGNC:HGNC:20564,MIM:300413 muscleblind like splicing regulator 3 GO:0003723,GO:0005634,GO:0005737,GO:0006397,GO:0007275,GO:0008380,GO:0043484,GO:0045662,GO:0046872 RNA binding|nucleus|cytoplasm|mRNA processing|multicellular organism development|RNA splicing|regulation of RNA splicing|negative regulation of myoblast differentiation|metal ion binding MBOAT1 160.876124412991 179.74729231131 142.004956514672 0.790025566942779 -0.340028752097991 0.165706751319214 1 1.16378 1.23976 1.13748 0.931558 GeneID:154141,Genbank:NM_001080480.2,HGNC:HGNC:21579,MIM:611732 membrane bound O-acyltransferase domain containing 1 GO:0003841,GO:0005789,GO:0008654,GO:0016021,GO:0036150,GO:0036152,GO:0047144 1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum membrane|phospholipid biosynthetic process|integral component of membrane|phosphatidylserine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|2-acylglycerol-3-phosphate O-acyltransferase activity hsa00561,hsa00564 Glycerolipid metabolism|Glycerophospholipid metabolism MBOAT2 444.36115862849 454.959404452371 433.76291280461 0.953410147278359 -0.0688311145917285 0.750567821348773 1 2.42044 1.93231 2.24163 1.91346 GeneID:129642,Genbank:NM_001321266.1,HGNC:HGNC:25193,MIM:611949 membrane bound O-acyltransferase domain containing 2 GO:0003841,GO:0005789,GO:0008654,GO:0016021,GO:0036151,GO:0036152,GO:0047144 1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum membrane|phospholipid biosynthetic process|integral component of membrane|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|2-acylglycerol-3-phosphate O-acyltransferase activity hsa00561,hsa00564 Glycerolipid metabolism|Glycerophospholipid metabolism MBOAT4 4.13711153157303 3.43049981370153 4.84372324944452 1.4119584645067 0.497697649564065 0.877404299385089 1 0 0.12237 0.0357738 0.133208 GeneID:619373,Genbank:XM_017013726.1,HGNC:HGNC:32311,MIM:611940 membrane bound O-acyltransferase domain containing 4 GO:0005789,GO:0008374,GO:0016412,GO:0018191,GO:0030176 endoplasmic reticulum membrane|O-acyltransferase activity|serine O-acyltransferase activity|peptidyl-serine octanoylation|integral component of endoplasmic reticulum membrane MBOAT7 3442.00597201795 3213.98518946768 3670.02675456823 1.14189286453311 0.191427299512176 0.163874789251051 1 44.4516 47.0115 54.7213 53.5573 GeneID:79143,Genbank:NM_001146056.2,HGNC:HGNC:15505,MIM:606048 membrane bound O-acyltransferase domain containing 7 GO:0003841,GO:0005789,GO:0008654,GO:0016020,GO:0016021,GO:0021591,GO:0021819,GO:0036149,GO:0047144,GO:0071617 1-acylglycerol-3-phosphate O-acyltransferase activity|endoplasmic reticulum membrane|phospholipid biosynthetic process|membrane|integral component of membrane|ventricular system development|layer formation in cerebral cortex|phosphatidylinositol acyl-chain remodeling|2-acylglycerol-3-phosphate O-acyltransferase activity|lysophospholipid acyltransferase activity hsa00564 Glycerophospholipid metabolism MBP 3.64627852403737 1.96028560782945 5.33227144024528 2.72015027756568 1.44368635688365 0.440326534440858 1 0 0.0132194 0.023725 0.0126695 GeneID:4155,Genbank:NM_001025101.1,HGNC:HGNC:6925,MIM:159430 myelin basic protein GO:0003964,GO:0004519,GO:0006310,GO:0046872 RNA-directed DNA polymerase activity|endonuclease activity|DNA recombination|metal ion binding MBTD1 168.58157796417 178.671096958025 158.492058970315 0.887060423698801 -0.172895715274694 0.473470867902915 1 0.921207 1.01277 1.03551 0.810517 GeneID:54799,Genbank:XM_011524928.2,HGNC:HGNC:19866 mbt domain containing 1 GO:0005634,GO:0006351,GO:0006355,GO:0008270,GO:0016569,GO:0035064,GO:0048706 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|covalent chromatin modification|methylated histone binding|embryonic skeletal system development MBTPS1 3866.2478001432 3683.91324231495 4048.58235797146 1.09898960471375 0.136177739973357 0.309120967102413 1 23.8784 23.3463 27.1345 25.708 GeneID:8720,Genbank:NM_003791.3,HGNC:HGNC:15456,MIM:603355 membrane bound transcription factor peptidase, site 1 GO:0000139,GO:0004222,GO:0004252,GO:0005788,GO:0005789,GO:0005795,GO:0006508,GO:0007040,GO:0008203,GO:0016021,GO:0030968,GO:0031293,GO:0034976,GO:0036500,GO:0042990,GO:0043687,GO:0044267,GO:0045540 Golgi membrane|metalloendopeptidase activity|serine-type endopeptidase activity|endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi stack|proteolysis|lysosome organization|cholesterol metabolic process|integral component of membrane|endoplasmic reticulum unfolded protein response|membrane protein intracellular domain proteolysis|response to endoplasmic reticulum stress|ATF6-mediated unfolded protein response|regulation of transcription factor import into nucleus|post-translational protein modification|cellular protein metabolic process|regulation of cholesterol biosynthetic process hsa04141 Protein processing in endoplasmic reticulum MBTPS2 361.662478319523 377.78009697335 345.544859665696 0.914671954489101 -0.128673678802466 0.510661436848171 1 4.12586 4.01739 3.90331 3.63653 GeneID:51360,Genbank:NM_015884.3,HGNC:HGNC:15455,MIM:300294 membrane bound transcription factor peptidase, site 2 GO:0000139,GO:0004222,GO:0005737,GO:0005789,GO:0008203,GO:0016021,GO:0030968,GO:0031293,GO:0034976,GO:0036500,GO:0045540,GO:0046872,GO:0051091,GO:1990440 Golgi membrane|metalloendopeptidase activity|cytoplasm|endoplasmic reticulum membrane|cholesterol metabolic process|integral component of membrane|endoplasmic reticulum unfolded protein response|membrane protein intracellular domain proteolysis|response to endoplasmic reticulum stress|ATF6-mediated unfolded protein response|regulation of cholesterol biosynthetic process|metal ion binding|positive regulation of DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress hsa04141 Protein processing in endoplasmic reticulum MC1R 73.2256277085522 66.0047347842264 80.4465206328781 1.21879924062816 0.285460506267385 0.415545696698378 1 0.926352 0.98551 1.14929 1.17488 GeneID:4157,Genbank:NM_002386.3,HGNC:HGNC:6929,MIM:155555 melanocortin 1 receptor hsa04080,hsa04916 Neuroactive ligand-receptor interaction|Melanogenesis MC4R 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0324485 0.0303062 GeneID:4160,Genbank:NM_005912.2,HGNC:HGNC:6932,MIM:155541 melanocortin 4 receptor hsa04080 Neuroactive ligand-receptor interaction MC5R 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0.044465 0 GeneID:4161,Genbank:NM_005913.2,HGNC:HGNC:6933,MIM:600042 melanocortin 5 receptor hsa04080 Neuroactive ligand-receptor interaction MCAM 3605.13203883817 3870.43834136197 3339.82573631438 0.862906327849968 -0.212724137662837 0.110098919766425 1 19.3898 21.1823 16.6768 18.7538 GeneID:4162,Genbank:XM_017017762.2,HGNC:HGNC:6934,MIM:155735 melanoma cell adhesion molecule MCAT 388.013872384583 405.78181046982 370.245934299346 0.91242614810819 -0.132220303207205 0.461888477198844 1 7.22953 8.61759 7.25926 7.32449 GeneID:27349,Genbank:NM_014507.3,HGNC:HGNC:29622,MIM:614479 malonyl-CoA-acyl carrier protein transacylase GO:0003723,GO:0004314,GO:0005739,GO:0005759,GO:0006633,GO:0006635,GO:0008152,GO:0016740 RNA binding|[acyl-carrier-protein] S-malonyltransferase activity|mitochondrion|mitochondrial matrix|fatty acid biosynthetic process|fatty acid beta-oxidation|metabolic process|transferase activity hsa00061 Fatty acid biosynthesis MCC 1743.4806100849 1558.94547153137 1928.01574863842 1.23674354481719 0.306546369369567 0.0309357839700259 0.695600514316014 2.19844 2.17215 3.10201 2.45667 GeneID:4163,Genbank:NM_001085377.1,HGNC:HGNC:6935,MIM:159350 mutated in colorectal cancers GO:0004872,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0010633,GO:0016055,GO:0030027,GO:0045184,GO:0050680,GO:0090090 receptor activity|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|signal transduction|negative regulation of epithelial cell migration|Wnt signaling pathway|lamellipodium|establishment of protein localization|negative regulation of epithelial cell proliferation|negative regulation of canonical Wnt signaling pathway MCCC1 724.169549234964 684.020594916888 764.318503553041 1.11739106867961 0.160134193971666 0.310693642499566 1 6.57494 5.96077 7.53077 6.13269 GeneID:56922,Genbank:NM_001293273.1,HGNC:HGNC:6936,MIM:609010 methylcrotonoyl-CoA carboxylase 1 GO:0002169,GO:0004075,GO:0004485,GO:0005524,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0006552,GO:0006768,GO:0009083,GO:0009374,GO:0046872,GO:0051291,GO:1905202 3-methylcrotonyl-CoA carboxylase complex, mitochondrial|biotin carboxylase activity|methylcrotonoyl-CoA carboxylase activity|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|leucine catabolic process|biotin metabolic process|branched-chain amino acid catabolic process|biotin binding|metal ion binding|protein heterooligomerization|methylcrotonoyl-CoA carboxylase complex hsa00280 Valine, leucine and isoleucine degradation MCCC2 2436.62042630321 2548.54400520132 2324.69684740511 0.912166649922716 -0.132630670658212 0.343898863752013 1 24.5364 24.2634 22.2622 22.7763 GeneID:64087,Genbank:NM_022132.4,HGNC:HGNC:6937,MIM:609014 methylcrotonoyl-CoA carboxylase 2 GO:0002169,GO:0004485,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006552,GO:0006768,GO:0009083,GO:0015936,GO:0051291,GO:1905202 3-methylcrotonyl-CoA carboxylase complex, mitochondrial|methylcrotonoyl-CoA carboxylase activity|ATP binding|mitochondrion|mitochondrial matrix|cytosol|leucine catabolic process|biotin metabolic process|branched-chain amino acid catabolic process|coenzyme A metabolic process|protein heterooligomerization|methylcrotonoyl-CoA carboxylase complex hsa00280 Valine, leucine and isoleucine degradation MCEE 48.1934893863548 53.2628783333349 43.1241004393747 0.809646451502137 -0.304636031350549 0.489637095412561 1 2.64127 2.43472 1.58318 2.54702 GeneID:84693,Genbank:NM_032601.3,HGNC:HGNC:16732,MIM:608419 methylmalonyl-CoA epimerase GO:0004493,GO:0005759,GO:0019626,GO:0046491,GO:0046872 methylmalonyl-CoA epimerase activity|mitochondrial matrix|short-chain fatty acid catabolic process|L-methylmalonyl-CoA metabolic process|metal ion binding hsa00280,hsa00630,hsa00640 Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism MCF2 2.99658855360761 3.084507235799 2.90866987141623 0.942993369462067 -0.0846804680780024 1 1 0.0163785 0.0159306 0.0158711 0.0146825 GeneID:4168,Genbank:XM_005262413.4,HGNC:HGNC:6940,MIM:311030 MCF.2 cell line derived transforming sequence GO:0005085,GO:0005089,GO:0005829,GO:0005856,GO:0007186,GO:0016020,GO:0035023,GO:0035556,GO:0043065,GO:0050771,GO:0051056,GO:0070062 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytosol|cytoskeleton|G-protein coupled receptor signaling pathway|membrane|regulation of Rho protein signal transduction|intracellular signal transduction|positive regulation of apoptotic process|negative regulation of axonogenesis|regulation of small GTPase mediated signal transduction|extracellular exosome MCF2L 17.7400195716853 15.1245698757774 20.3554692675932 1.34585442328468 0.428522366736047 0.52477584189006 1 0.0673957 0.0300673 0.0900811 0.0378229 GeneID:23263,Genbank:XM_011537482.1,HGNC:HGNC:14576,MIM:609499 MCF.2 cell line derived transforming sequence like GO:0005085,GO:0005089,GO:0005615,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0012505,GO:0031234,GO:0035023,GO:0035025,GO:0035091,GO:0035556,GO:0043065,GO:0051056 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|extracellular space|cytoplasm|cytosol|plasma membrane|G-protein coupled receptor signaling pathway|endomembrane system|extrinsic component of cytoplasmic side of plasma membrane|regulation of Rho protein signal transduction|positive regulation of Rho protein signal transduction|phosphatidylinositol binding|intracellular signal transduction|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction MCF2L2 41.0984818055397 42.9429699277613 39.2539936833181 0.914095921855224 -0.129582530562735 0.785864106104527 1 0.104559 0.121836 0.103597 0.0965462 GeneID:23101,Genbank:XM_011512586.2,HGNC:HGNC:30319 MCF.2 cell line derived transforming sequence-like 2 GO:0005089,GO:0035023 Rho guanyl-nucleotide exchange factor activity|regulation of Rho protein signal transduction MCFD2 3959.96148807265 4409.77997749525 3510.14299865005 0.795990506683694 -0.329176870201388 0.0148953500560285 0.508665088480495 36.6666 35.2698 29.4183 28.1373 GeneID:90411,Genbank:NM_001171511.2,HGNC:HGNC:18451,MIM:607788 multiple coagulation factor deficiency 2 GO:0000139,GO:0005509,GO:0005789,GO:0006888,GO:0012507,GO:0015031,GO:0018279,GO:0033116,GO:0048208 Golgi membrane|calcium ion binding|endoplasmic reticulum membrane|ER to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|protein transport|protein N-linked glycosylation via asparagine|endoplasmic reticulum-Golgi intermediate compartment membrane|COPII vesicle coating MCIDAS 10.8811426244332 9.15746915802711 12.6048160908392 1.37645192938382 0.460954226751086 0.64298568460532 1 0.0752067 0.136608 0.212487 0.0792743 GeneID:345643,Genbank:XM_017009439.2,HGNC:HGNC:40050,MIM:614086 multiciliate differentiation and DNA synthesis associated cell cycle protein GO:0003713,GO:0005634,GO:0006275,GO:0006351,GO:0007049,GO:0007346,GO:0016604,GO:0042802,GO:0044458,GO:0045944,GO:0060271,GO:0098534,GO:1903251 transcription coactivator activity|nucleus|regulation of DNA replication|transcription, DNA-templated|cell cycle|regulation of mitotic cell cycle|nuclear body|identical protein binding|motile cilium assembly|positive regulation of transcription from RNA polymerase II promoter|cilium assembly|centriole assembly|multi-ciliated epithelial cell differentiation MCL1 5378.06872204228 5617.67571409515 5138.4617299894 0.914695328015576 -0.128636812645454 0.349199817927134 1 67.8776 63.5984 68.0399 53.7886 GeneID:4170,Genbank:NM_001197320.1,HGNC:HGNC:6943,MIM:159552 MCL1, BCL2 family apoptosis regulator hsa04151,hsa04210,hsa04630,hsa05206 PI3K-Akt signaling pathway|Apoptosis|Jak-STAT signaling pathway|MicroRNAs in cancer MCM10 691.408101242349 759.085729308917 623.730473175781 0.821686469779421 -0.283340083925328 0.12792385622611 1 5.30988 4.60644 4.2115 3.92831 GeneID:55388,Genbank:NM_182751.2,HGNC:HGNC:18043,MIM:609357 minichromosome maintenance 10 replication initiation factor GO:0000082,GO:0003688,GO:0003697,GO:0005634,GO:0005654,GO:0005730,GO:0006260,GO:0006270,GO:0006974,GO:0008283,GO:0019899,GO:0031298,GO:0042802,GO:0046872 G1/S transition of mitotic cell cycle|DNA replication origin binding|single-stranded DNA binding|nucleus|nucleoplasm|nucleolus|DNA replication|DNA replication initiation|cellular response to DNA damage stimulus|cell proliferation|enzyme binding|replication fork protection complex|identical protein binding|metal ion binding MCM2 5456.22649340368 5342.30905882751 5570.14392797986 1.04264726481443 0.0602511661282938 0.668887067925588 1 50.5147 53.6955 54.5759 55.0288 GeneID:4171,Genbank:NM_004526.3,HGNC:HGNC:6944,MIM:116945 minichromosome maintenance complex component 2 hsa03030,hsa04110 DNA replication|Cell cycle MCM3 7952.61347777457 7903.67811337142 8001.54884217771 1.01238293455306 0.0177550936722729 0.89528594873429 1 68.022 69.1061 70.9826 69.8822 GeneID:4172,Genbank:NM_001270472.1,HGNC:HGNC:6945,MIM:602693 minichromosome maintenance complex component 3 hsa03030,hsa04110 DNA replication|Cell cycle MCM3AP 2633.58595949585 2528.40508544809 2738.76683354361 1.08319938498234 0.11529882489411 0.406177734512759 1 13.026 13.2051 15.7079 13.5013 GeneID:8888,Genbank:NM_003906.4,HGNC:HGNC:6946,MIM:603294 minichromosome maintenance complex component 3 associated protein MCM4 7976.00366459944 8168.72318758522 7783.28414161366 0.952815264133647 -0.0697315694755087 0.595941968991031 1 66.5053 65.6132 66.685 60.9366 GeneID:4173,Genbank:NM_005914.3,HGNC:HGNC:6947,MIM:602638 minichromosome maintenance complex component 4 hsa03030,hsa04110 DNA replication|Cell cycle MCM5 3335.15034126025 3163.12464186944 3507.17604065106 1.10876947251066 0.148959441751029 0.282967636202949 1 35.7229 37.8563 41.5669 41.7253 GeneID:4174,Genbank:NM_006739.3,HGNC:HGNC:6948,MIM:602696 minichromosome maintenance complex component 5 hsa03030,hsa04110 DNA replication|Cell cycle MCM6 2124.55543050318 2132.69324335531 2116.41761765105 0.992368510682456 -0.0110521377737315 0.941937854061162 1 19.4144 19.6879 20.2869 18.3755 GeneID:4175,Genbank:NM_005915.5,HGNC:HGNC:6949,MIM:601806 minichromosome maintenance complex component 6 hsa03030,hsa04110 DNA replication|Cell cycle MCM7 14081.0157772479 14061.2549182944 14100.7766362013 1.00281068212876 0.00404926922636378 0.994706565609844 1 115.713 124.678 120.756 123.716 GeneID:4176,Genbank:NM_005916.4,HGNC:HGNC:6950,MIM:600592 minichromosome maintenance complex component 7 GO:0000082,GO:0000784,GO:0000785,GO:0003678,GO:0003697,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006268,GO:0006270,GO:0006974,GO:0008283,GO:0016020,GO:0042325,GO:0042493,GO:0042555,GO:0071364,GO:0071466 G1/S transition of mitotic cell cycle|nuclear chromosome, telomeric region|chromatin|DNA helicase activity|single-stranded DNA binding|ATP binding|nucleus|nucleoplasm|cytosol|DNA replication|DNA unwinding involved in DNA replication|DNA replication initiation|cellular response to DNA damage stimulus|cell proliferation|membrane|regulation of phosphorylation|response to drug|MCM complex|cellular response to epidermal growth factor stimulus|cellular response to xenobiotic stimulus hsa03030,hsa04110 DNA replication|Cell cycle MCM8 656.200836613723 726.396041202683 586.005632024763 0.80673021159989 -0.309841809813 0.234560639170629 1 2.13724 1.86993 1.95639 1.36012 GeneID:84515,Genbank:NM_001281520.1,HGNC:HGNC:16147,MIM:608187 minichromosome maintenance 8 homologous recombination repair factor GO:0000082,GO:0000724,GO:0003677,GO:0004386,GO:0005524,GO:0005654,GO:0006260,GO:0006270,GO:0006974,GO:0007292,GO:0048232,GO:0097362 G1/S transition of mitotic cell cycle|double-strand break repair via homologous recombination|DNA binding|helicase activity|ATP binding|nucleoplasm|DNA replication|DNA replication initiation|cellular response to DNA damage stimulus|female gamete generation|male gamete generation|MCM8-MCM9 complex MCM9 236.608500432465 253.679413421116 219.537587443813 0.865413493681389 -0.208538479194054 0.33239494119178 1 1.39881 1.47919 1.21273 1.12274 GeneID:254394,Genbank:NM_017696.2,HGNC:HGNC:21484,MIM:610098 minichromosome maintenance 9 homologous recombination repair factor GO:0000724,GO:0003677,GO:0004386,GO:0005524,GO:0005634,GO:0006270,GO:0006974,GO:0007292,GO:0097362 double-strand break repair via homologous recombination|DNA binding|helicase activity|ATP binding|nucleus|DNA replication initiation|cellular response to DNA damage stimulus|female gamete generation|MCM8-MCM9 complex MCMBP 2827.74953344042 2982.19122499695 2673.30784188389 0.8964240185123 -0.15774679038939 0.254223040483933 1 25.1276 24.7434 24.3644 20.9027 GeneID:79892,Genbank:NM_001256379.1,HGNC:HGNC:25782,MIM:610909 minichromosome maintenance complex binding protein GO:0000790,GO:0003682,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006261,GO:0007062,GO:0051301 nuclear chromatin|chromatin binding|nucleus|nucleoplasm|cytosol|plasma membrane|DNA-dependent DNA replication|sister chromatid cohesion|cell division MCMDC2 69.8543353539503 87.3943716809716 52.314299026929 0.598600321973816 -0.740335040057525 0.238800539729626 1 0.0546961 0.019849 0.0065807 0.0796247 GeneID:157777,Genbank:NM_173518.4,HGNC:HGNC:26368,MIM:617545 minichromosome maintenance domain containing 2 GO:0003677,GO:0005524,GO:0006270,GO:0007130,GO:0007283,GO:0042140,GO:0048477,GO:1990918 DNA binding|ATP binding|DNA replication initiation|synaptonemal complex assembly|spermatogenesis|late meiotic recombination nodule assembly|oogenesis|double-strand break repair involved in meiotic recombination MCOLN1 968.862040601008 925.854084798475 1011.86999640354 1.0929043928383 0.128167199718863 0.426097568094202 1 20.009 22.1419 23.1982 23.9087 GeneID:57192,Genbank:NM_020533.2,HGNC:HGNC:13356,MIM:605248 mucolipin 1 GO:0001891,GO:0002250,GO:0005261,GO:0005262,GO:0005381,GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0005886,GO:0005887,GO:0006812,GO:0008289,GO:0010008,GO:0016021,GO:0030670,GO:0031902,GO:0033572,GO:0042995,GO:0043235,GO:0051289,GO:0070588,GO:0071277,GO:0071467,GO:0072345,GO:0097352,GO:0097682,GO:0099604 phagocytic cup|adaptive immune response|cation channel activity|calcium channel activity|iron ion transmembrane transporter activity|lysosome|lysosomal membrane|late endosome|cytosol|plasma membrane|integral component of plasma membrane|cation transport|lipid binding|endosome membrane|integral component of membrane|phagocytic vesicle membrane|late endosome membrane|transferrin transport|cell projection|receptor complex|protein homotetramerization|calcium ion transmembrane transport|cellular response to calcium ion|cellular response to pH|NAADP-sensitive calcium-release channel activity|autophagosome maturation|intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity|ligand-gated calcium channel activity hsa04142 Lysosome MCOLN2 225.004190185116 211.562698818107 238.445681552126 1.12706863206133 0.172575370097296 0.431084675341937 1 1.9526 2.10488 2.52842 2.06808 GeneID:255231,Genbank:NM_153259.3,HGNC:HGNC:13357,MIM:607399 mucolipin 2 GO:0002250,GO:0005262,GO:0005765,GO:0005886,GO:0016021,GO:0031902,GO:0035926,GO:0045087,GO:0051259,GO:0055038,GO:0070588,GO:0071639,GO:0071642,GO:0071651,GO:1905517,GO:1990266,GO:2000343 adaptive immune response|calcium channel activity|lysosomal membrane|plasma membrane|integral component of membrane|late endosome membrane|chemokine (C-C motif) ligand 2 secretion|innate immune response|protein oligomerization|recycling endosome membrane|calcium ion transmembrane transport|positive regulation of monocyte chemotactic protein-1 production|positive regulation of macrophage inflammatory protein 1 alpha production|positive regulation of chemokine (C-C motif) ligand 5 production|macrophage migration|neutrophil migration|positive regulation of chemokine (C-X-C motif) ligand 2 production MCOLN3 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0250319 0 0 0 GeneID:55283,Genbank:XM_005271003.1,HGNC:HGNC:13358,MIM:607400 mucolipin 3 GO:0000421,GO:0005262,GO:0005765,GO:0005886,GO:0007626,GO:0008289,GO:0016021,GO:0031901,GO:0031902,GO:0042491,GO:0070588 autophagosome membrane|calcium channel activity|lysosomal membrane|plasma membrane|locomotory behavior|lipid binding|integral component of membrane|early endosome membrane|late endosome membrane|inner ear auditory receptor cell differentiation|calcium ion transmembrane transport MCPH1 513.602766166929 538.212690854475 488.992841479382 0.908549444835738 -0.138363064326455 0.442468809609545 1 0.773661 0.697975 0.697093 0.652513 GeneID:79648,Genbank:NM_001322042.1,HGNC:HGNC:6954,MIM:607117 microcephalin 1 MCRIP1 1332.51288060413 1265.00580191231 1400.01995929594 1.10673006967994 0.146303393193802 0.331047343538322 1 38.2991 38.1767 41.7044 43.3835 GeneID:348262,Genbank:NM_001288799.1,HGNC:HGNC:28007,MIM:616514 MAPK regulated corepressor interacting protein 1 GO:0005634,GO:0005737,GO:0010494,GO:0010717 nucleus|cytoplasm|cytoplasmic stress granule|regulation of epithelial to mesenchymal transition MCRIP2 431.658073938485 359.312288178988 504.003859697983 1.40269029554291 0.488196506885853 0.00760238587492272 0.342174250855479 16.5881 17.8483 24.447 27.3281 GeneID:84331,Genbank:NM_138418.3,HGNC:HGNC:14142 MAPK regulated corepressor interacting protein 2 GO:0005634,GO:0005737,GO:0010494 nucleus|cytoplasm|cytoplasmic stress granule MCRS1 1348.59557375071 1306.37269642972 1390.81845107169 1.06464139588401 0.0903675680090388 0.552386211525039 1 15.769 16.3812 16.7716 18.0379 GeneID:10445,Genbank:NM_001278341.1,HGNC:HGNC:6960,MIM:609504 microspherule protein 1 GO:0000123,GO:0002151,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005844,GO:0006281,GO:0006310,GO:0006351,GO:0006355,GO:0006464,GO:0008266,GO:0010521,GO:0016579,GO:0030425,GO:0031011,GO:0034046,GO:0043204,GO:0043981,GO:0043982,GO:0043984,GO:0051974,GO:0071339,GO:1904357,GO:1904751 histone acetyltransferase complex|G-quadruplex RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|polysome|DNA repair|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular protein modification process|poly(U) RNA binding|telomerase inhibitor activity|protein deubiquitination|dendrite|Ino80 complex|poly(G) binding|perikaryon|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|negative regulation of telomerase activity|MLL1 complex|negative regulation of telomere maintenance via telomere lengthening|positive regulation of protein localization to nucleolus hsa05168 Herpes simplex infection MCTP1 175.399693428349 156.906041518054 193.893345338645 1.23572899719311 0.305362386224526 0.447774277596043 1 0.758829 0.565598 0.934671 0.576488 GeneID:79772,Genbank:XM_017009856.1,HGNC:HGNC:26183,MIM:616296 multiple C2 and transmembrane domain containing 1 GO:0005509,GO:0005783,GO:0005789,GO:0016021,GO:0019722,GO:0030054,GO:0030336,GO:0030672,GO:0045806,GO:0046928,GO:0048168,GO:0055037,GO:1902883 calcium ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|calcium-mediated signaling|cell junction|negative regulation of cell migration|synaptic vesicle membrane|negative regulation of endocytosis|regulation of neurotransmitter secretion|regulation of neuronal synaptic plasticity|recycling endosome|negative regulation of response to oxidative stress MCTS1 1837.27999284347 1727.32506904829 1947.23491663864 1.12731236958861 0.172887330607078 0.219905080574799 1 4.71794 4.84583 5.52991 5.39782 GeneID:28985,Genbank:NM_014060.2,HGNC:HGNC:23357,MIM:300587 MCTS1, re-initiation and release factor GO:0001731,GO:0002188,GO:0003723,GO:0005886,GO:0006351,GO:0006355,GO:0006974,GO:0007049,GO:0022627,GO:0032790,GO:0040008,GO:0075522 formation of translation preinitiation complex|translation reinitiation|RNA binding|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|cell cycle|cytosolic small ribosomal subunit|ribosome disassembly|regulation of growth|IRES-dependent viral translational initiation MCU 1160.05488166331 1109.405261465 1210.70450186161 1.09130950060832 0.126060314924478 0.403550951012545 1 10.3272 11.1337 13.3205 10.2624 GeneID:90550,Genbank:NM_001270679.1,HGNC:HGNC:23526,MIM:614197 mitochondrial calcium uniporter GO:0005262,GO:0005739,GO:0005743,GO:0006851,GO:0015292,GO:0019722,GO:0031305,GO:0032024,GO:0034704,GO:0035786,GO:0036444,GO:0042593,GO:0042802,GO:0051561,GO:1990246 calcium channel activity|mitochondrion|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|uniporter activity|calcium-mediated signaling|integral component of mitochondrial inner membrane|positive regulation of insulin secretion|calcium channel complex|protein complex oligomerization|mitochondrial calcium uptake|glucose homeostasis|identical protein binding|positive regulation of mitochondrial calcium ion concentration|uniplex complex hsa04020,hsa04218,hsa04621 Calcium signaling pathway|Cellular senescence|NOD-like receptor signaling pathway MCUB 780.020064254579 791.441267494065 768.598861015092 0.971138216546 -0.0422514540989489 0.789212525308068 1 12.2046 12.6426 11.993 12.0275 GeneID:55013,Genbank:NM_017918.4,HGNC:HGNC:26076 mitochondrial calcium uniporter dominant negative beta subunit GO:0005739,GO:0005743,GO:0006851,GO:0019855,GO:0031224,GO:0031305,GO:0034704,GO:0036444,GO:0051560,GO:1990246 mitochondrion|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|calcium channel inhibitor activity|intrinsic component of membrane|integral component of mitochondrial inner membrane|calcium channel complex|mitochondrial calcium uptake|mitochondrial calcium ion homeostasis|uniplex complex MCUR1 1405.13665718102 1487.1843414375 1323.08897292454 0.889660370983773 -0.168673404438683 0.255138322764975 1 12.5667 12.0085 12.0388 9.87103 GeneID:63933,Genbank:NM_001031713.3,HGNC:HGNC:21097,MIM:616952 mitochondrial calcium uniporter regulator 1 GO:0006851,GO:0031305,GO:0036444,GO:0051561,GO:0070509 mitochondrial calcium ion transmembrane transport|integral component of mitochondrial inner membrane|mitochondrial calcium uptake|positive regulation of mitochondrial calcium ion concentration|calcium ion import MDC1 1942.22086531735 2000.68377378686 1883.75795684783 0.941557072401446 -0.0868795485608381 0.542635282809445 1 6.33242 6.14492 5.98462 5.79788 GeneID:9656,Genbank:XM_005249494.5,HGNC:HGNC:21163,MIM:607593 mediator of DNA damage checkpoint 1 GO:0005634,GO:0005654,GO:0005694,GO:0005925,GO:0006303,GO:0008022,GO:0016604,GO:0031573,GO:0070975 nucleus|nucleoplasm|chromosome|focal adhesion|double-strand break repair via nonhomologous end joining|protein C-terminus binding|nuclear body|intra-S DNA damage checkpoint|FHA domain binding MDFI 2.24540794841108 3.03648096111406 1.45433493570811 0.478954076884622 -1.06204076090285 0.698588477556558 1 0.0171516 0.0583395 0.0314355 0.0147812 GeneID:4188,Genbank:XM_011514626.2,HGNC:HGNC:6967,MIM:604971 MyoD family inhibitor GO:0000122,GO:0005634,GO:0005737,GO:0008134,GO:0009790,GO:0009950,GO:0030178,GO:0042802,GO:0042994,GO:0043392,GO:0045892,GO:0048704,GO:0060707 negative regulation of transcription from RNA polymerase II promoter|nucleus|cytoplasm|transcription factor binding|embryo development|dorsal/ventral axis specification|negative regulation of Wnt signaling pathway|identical protein binding|cytoplasmic sequestering of transcription factor|negative regulation of DNA binding|negative regulation of transcription, DNA-templated|embryonic skeletal system morphogenesis|trophoblast giant cell differentiation MDFIC 617.067760040591 598.720779012692 635.414741068489 1.06128727002979 0.0858152188836251 0.640180272764282 1 5.43741 4.75173 6.19107 4.788 GeneID:29969,Genbank:NM_199072.4,HGNC:HGNC:28870,MIM:614511 MyoD family inhibitor domain containing GO:0005634,GO:0005730,GO:0005737,GO:0006351,GO:0007257,GO:0008134,GO:0016032,GO:0030111,GO:0030332,GO:0030957,GO:0042308,GO:0045892,GO:0045893,GO:0050434 nucleus|nucleolus|cytoplasm|transcription, DNA-templated|activation of JUN kinase activity|transcription factor binding|viral process|regulation of Wnt signaling pathway|cyclin binding|Tat protein binding|negative regulation of protein import into nucleus|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of viral transcription MDGA1 673.928628765261 615.471484575214 732.385772955307 1.18995890355633 0.250911749449784 0.406144875684191 1 2.15621 2.61637 3.47441 2.3236 GeneID:266727,Genbank:NM_153487.3,HGNC:HGNC:19267,MIM:609626 MAM domain containing glycosylphosphatidylinositol anchor 1 GO:0001764,GO:0005576,GO:0005615,GO:0005886,GO:0006501,GO:0007420,GO:0021527,GO:0046658 neuron migration|extracellular region|extracellular space|plasma membrane|C-terminal protein lipidation|brain development|spinal cord association neuron differentiation|anchored component of plasma membrane MDH1 3845.47991918878 3811.59933016091 3879.36050821664 1.01777762356068 0.0254223782779046 0.852348812239667 1 77.8584 79.2188 81.3894 81.9946 GeneID:4190,Genbank:NM_005917.3,HGNC:HGNC:6970,MIM:154200 malate dehydrogenase 1 hsa00020,hsa00270,hsa00620,hsa00630,hsa04964 Citrate cycle (TCA cycle)|Cysteine and methionine metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism|Proximal tubule bicarbonate reclamation MDH1B 24.243508326074 25.7140356200996 22.7729810320485 0.885624542506575 -0.175232892119844 0.794975316078723 1 0.220561 0.389132 0.181869 0.239276 GeneID:130752,Genbank:NM_001330225.1,HGNC:HGNC:17836 malate dehydrogenase 1B GO:0005737,GO:0005975,GO:0006099,GO:0006107,GO:0006108,GO:0006734,GO:0030060 cytoplasm|carbohydrate metabolic process|tricarboxylic acid cycle|oxaloacetate metabolic process|malate metabolic process|NADH metabolic process|L-malate dehydrogenase activity MDH2 8631.78527707034 8900.89153475779 8362.67901938289 0.939532740818918 -0.0899846573569269 0.481490735567331 1 161.639 168.511 149.178 164.578 GeneID:4191,Genbank:NM_005918.3,HGNC:HGNC:6971,MIM:154100 malate dehydrogenase 2 hsa00020,hsa00270,hsa00620,hsa00630 Citrate cycle (TCA cycle)|Cysteine and methionine metabolism|Pyruvate metabolism|Glyoxylate and dicarboxylate metabolism MDK 1158.87187397955 1102.8902544155 1214.8534935436 1.10151802382861 0.139493101643805 0.413072708192065 1 31.2257 29.1712 31.0586 36.923 GeneID:4192,Genbank:NM_001270550.1,HGNC:HGNC:6972,MIM:162096 midkine GO:0001662,GO:0005576,GO:0005737,GO:0007165,GO:0007219,GO:0007399,GO:0007614,GO:0008083,GO:0008201,GO:0009611,GO:0016477,GO:0021542,GO:0021681,GO:0021987,GO:0030154,GO:0030325,GO:0030421,GO:0042493,GO:0042995,GO:0043524,GO:0045893,GO:0050795,GO:0051384,GO:0051781 behavioral fear response|extracellular region|cytoplasm|signal transduction|Notch signaling pathway|nervous system development|short-term memory|growth factor activity|heparin binding|response to wounding|cell migration|dentate gyrus development|cerebellar granular layer development|cerebral cortex development|cell differentiation|adrenal gland development|defecation|response to drug|cell projection|negative regulation of neuron apoptotic process|positive regulation of transcription, DNA-templated|regulation of behavior|response to glucocorticoid|positive regulation of cell division MDM1 186.351405127275 184.176535238287 188.526275016264 1.02361723100258 0.0336763382195119 0.868902173631453 1 0.820393 0.705219 0.927288 0.785681 GeneID:56890,Genbank:NM_001354974.1,HGNC:HGNC:29917,MIM:613813 Mdm1 nuclear protein GO:0005634,GO:0005813,GO:0005814,GO:0005829,GO:0005874,GO:0008017,GO:0046600,GO:0060041 nucleus|centrosome|centriole|cytosol|microtubule|microtubule binding|negative regulation of centriole replication|retina development in camera-type eye MDM2 765.114959478031 779.947077184128 750.282841771935 0.961966348384444 -0.0559416685303455 0.824326845968955 1 4.40654 3.82498 4.53204 3.50427 GeneID:4193,Genbank:XM_006719400.4,HGNC:HGNC:6973,MIM:164785 MDM2 proto-oncogene hsa01522,hsa01524,hsa04068,hsa04110,hsa04115,hsa04120,hsa04144,hsa04151,hsa04218,hsa04625,hsa04919,hsa05163,hsa05165,hsa05169,hsa05200,hsa05202,hsa05203,hsa05205,hsa05206,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220 Endocrine resistance|Platinum drug resistance|FoxO signaling pathway|Cell cycle|p53 signaling pathway|Ubiquitin mediated proteolysis|Endocytosis|PI3K-Akt signaling pathway|Cellular senescence|C-type lectin receptor signaling pathway|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia MDM4 258.916172170565 250.777202628949 267.055141712181 1.06490996355565 0.0907314580353174 0.662692227159685 1 1.08361 1.03625 1.29871 0.980149 GeneID:4194,Genbank:XM_024447114.1,HGNC:HGNC:6974,MIM:602704 MDM4, p53 regulator hsa04115,hsa05206 p53 signaling pathway|MicroRNAs in cancer MDN1 1115.79593761076 1276.70764662778 954.88422859374 0.747927085042462 -0.419030465382915 0.0756347296412249 0.94157495521624 1.92695 1.82653 1.69048 1.08892 GeneID:23195,Genbank:XM_011535635.2,HGNC:HGNC:18302 midasin AAA ATPase 1 GO:0000027,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0006461,GO:0016020,GO:0016887,GO:0030687,GO:0045111,GO:0051082 ribosomal large subunit assembly|ATP binding|nucleus|nucleoplasm|nucleolus|cytosol|rRNA processing|protein complex assembly|membrane|ATPase activity|preribosome, large subunit precursor|intermediate filament cytoskeleton|unfolded protein binding hsa03008 Ribosome biogenesis in eukaryotes MDP1 18.9145618857336 17.4788743361943 20.3502494352728 1.16427688899465 0.219434201609629 0.767431000001016 1 3.64204 4.80536 4.68577 4.99696 GeneID:145553,Genbank:NM_001199821.1,HGNC:HGNC:28781 magnesium dependent phosphatase 1 GO:0004725,GO:0030389,GO:0046872,GO:0070062 protein tyrosine phosphatase activity|fructosamine metabolic process|metal ion binding|extracellular exosome ME1 2.96757231689495 2.05633815719933 3.87880647659057 1.88626878464064 0.915535268080234 0.688044533133281 1 0.0258586 0.0249475 0.0499146 0.0115962 GeneID:4199,Genbank:NM_002395.5,HGNC:HGNC:6983,MIM:154250 malic enzyme 1 hsa00620,hsa03320 Pyruvate metabolism|PPAR signaling pathway ME2 513.827773523979 526.018740735334 501.636806312624 0.953648163963464 -0.0684709939902686 0.718153613221724 1 5.11186 4.61144 5.30657 4.13047 GeneID:4200,Genbank:NM_002396.4,HGNC:HGNC:6984,MIM:154270 malic enzyme 2 GO:0004470,GO:0004471,GO:0004473,GO:0005739,GO:0005759,GO:0006090,GO:0006108,GO:0008948,GO:0009055,GO:0046872,GO:0051287,GO:1902031 malic enzyme activity|malate dehydrogenase (decarboxylating) (NAD+) activity|malate dehydrogenase (decarboxylating) (NADP+) activity|mitochondrion|mitochondrial matrix|pyruvate metabolic process|malate metabolic process|oxaloacetate decarboxylase activity|electron transfer activity|metal ion binding|NAD binding|regulation of NADP metabolic process hsa00620 Pyruvate metabolism ME3 2.48544055001957 2.54640955915669 2.42447154088245 0.952113744689749 -0.0707941588569123 1 1 0.0111569 0.0100712 0.0420442 0 GeneID:10873,Genbank:XM_017017136.1,HGNC:HGNC:6985,MIM:604626 malic enzyme 3 GO:0004470,GO:0004471,GO:0004473,GO:0005739,GO:0005759,GO:0006090,GO:0006108,GO:0008948,GO:0009060,GO:0046872,GO:0048037,GO:0051287,GO:0055114,GO:0072592 malic enzyme activity|malate dehydrogenase (decarboxylating) (NAD+) activity|malate dehydrogenase (decarboxylating) (NADP+) activity|mitochondrion|mitochondrial matrix|pyruvate metabolic process|malate metabolic process|oxaloacetate decarboxylase activity|aerobic respiration|metal ion binding|cofactor binding|NAD binding|oxidation-reduction process|oxygen metabolic process hsa00620 Pyruvate metabolism MEA1 3579.74954867334 3367.98902019356 3791.51007715311 1.12574894229768 0.17088512218999 0.211380768593812 1 40.2573 42.6746 45.1786 48.5552 GeneID:4201,Genbank:XM_017010868.1,HGNC:HGNC:6986,MIM:143170 male-enhanced antigen 1 GO:0005737,GO:0007283,GO:0008584,GO:0030154 cytoplasm|spermatogenesis|male gonad development|cell differentiation MEAF6 895.56111362273 914.907800820287 876.214426425172 0.957707897604083 -0.0623423960632285 0.693190457584401 1 7.35109 7.23232 7.46728 6.95825 GeneID:64769,Genbank:NM_001270876.1,HGNC:HGNC:25674,MIM:611001 MYST/Esa1 associated factor 6 GO:0000776,GO:0000777,GO:0005654,GO:0005730,GO:0006351,GO:0006355,GO:0035267,GO:0043968,GO:0043981,GO:0043982,GO:0043983,GO:0044154,GO:0070776,GO:1901796 kinetochore|condensed chromosome kinetochore|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|NuA4 histone acetyltransferase complex|histone H2A acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K12 acetylation|histone H3-K14 acetylation|MOZ/MORF histone acetyltransferase complex|regulation of signal transduction by p53 class mediator MECOM 143.893767026605 162.2488006649 125.53873338831 0.773742134757541 -0.370075255767521 0.15915712398412 1 0.663448 0.56884 0.580523 0.383012 GeneID:2122,Genbank:NM_001205194.1,HGNC:HGNC:3498,MIM:165215 MDS1 and EVI1 complex locus GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006915,GO:0016607,GO:0018024,GO:0030154,GO:0042803,GO:0043069,GO:0045892,GO:0045893,GO:0046329,GO:0046872,GO:0051726,GO:0071425 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|apoptotic process|nuclear speck|histone-lysine N-methyltransferase activity|cell differentiation|protein homodimerization activity|negative regulation of programmed cell death|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of JNK cascade|metal ion binding|regulation of cell cycle|hematopoietic stem cell proliferation hsa04010,hsa05200,hsa05220 MAPK signaling pathway|Pathways in cancer|Chronic myeloid leukemia MECP2 3543.08374008489 3512.9412429659 3573.22623720388 1.01716083192643 0.0245478139815372 0.866456397799561 1 12.4136 12.7896 13.4004 12.3708 GeneID:4204,Genbank:XM_024452383.1,HGNC:HGNC:6990,MIM:300005 methyl-CpG binding protein 2 GO:0000122,GO:0005634,GO:0006351,GO:0010385 negative regulation of transcription from RNA polymerase II promoter|nucleus|transcription, DNA-templated|double-stranded methylated DNA binding MECR 424.756483035998 415.813561227284 433.699404844712 1.04301409402001 0.0607586528101232 0.783329749805081 1 2.56503 3.18507 2.67075 3.30255 GeneID:51102,Genbank:NM_001349717.1,HGNC:HGNC:19691,MIM:608205 mitochondrial trans-2-enoyl-CoA reductase GO:0005634,GO:0005739,GO:0005759,GO:0006631,GO:0006633,GO:0006635,GO:0019166 nucleus|mitochondrion|mitochondrial matrix|fatty acid metabolic process|fatty acid biosynthetic process|fatty acid beta-oxidation|trans-2-enoyl-CoA reductase (NADPH) activity hsa00062 Fatty acid elongation MED1 2344.13247510034 2496.55821897426 2191.70673122641 0.877891296333118 -0.187885783771527 0.21141538953368 1 10.892 10.3548 10.7405 8.19052 GeneID:5469,Genbank:XM_005257465.3,HGNC:HGNC:9234,MIM:604311 mediator complex subunit 1 GO:0000122,GO:0000151,GO:0000785,GO:0000902,GO:0000978,GO:0000979,GO:0000981,GO:0001047,GO:0001104,GO:0001525,GO:0001889,GO:0001892,GO:0002088,GO:0002154,GO:0003222,GO:0003406,GO:0003682,GO:0003712,GO:0003713,GO:0004872,GO:0005634,GO:0005654,GO:0005730,GO:0006356,GO:0006367,GO:0006590,GO:0006702,GO:0007420,GO:0007595,GO:0008134,GO:0010628,GO:0010839,GO:0016020,GO:0016592,GO:0016922,GO:0019216,GO:0030216,GO:0030224,GO:0030331,GO:0030374,GO:0030375,GO:0030518,GO:0030521,GO:0031100,GO:0031490,GO:0032993,GO:0033148,GO:0033160,GO:0033601,GO:0035050,GO:0035116,GO:0035162,GO:0035257,GO:0035357,GO:0035729,GO:0035855,GO:0036033,GO:0042789,GO:0042809,GO:0042974,GO:0042975,GO:0043066,GO:0045444,GO:0045618,GO:0045648,GO:0045665,GO:0045893,GO:0045944,GO:0046966,GO:0048821,GO:0048822,GO:0050693,GO:0051726,GO:0060335,GO:0060744,GO:0060745,GO:0060750,GO:0061630,GO:0070318,GO:0070371,GO:0070562,GO:0071364,GO:0071383,GO:0097067,GO:2000273,GO:2000347,GO:2001141 negative regulation of transcription from RNA polymerase II promoter|ubiquitin ligase complex|chromatin|cell morphogenesis|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|core promoter binding|RNA polymerase II transcription cofactor activity|angiogenesis|liver development|embryonic placenta development|lens development in camera-type eye|thyroid hormone mediated signaling pathway|ventricular trabecula myocardium morphogenesis|retinal pigment epithelium development|chromatin binding|transcription cofactor activity|transcription coactivator activity|receptor activity|nucleus|nucleoplasm|nucleolus|regulation of transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|thyroid hormone generation|androgen biosynthetic process|brain development|lactation|transcription factor binding|positive regulation of gene expression|negative regulation of keratinocyte proliferation|membrane|mediator complex|ligand-dependent nuclear receptor binding|regulation of lipid metabolic process|keratinocyte differentiation|monocyte differentiation|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|thyroid hormone receptor coactivator activity|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|animal organ regeneration|chromatin DNA binding|protein-DNA complex|positive regulation of intracellular estrogen receptor signaling pathway|positive regulation of protein import into nucleus, translocation|positive regulation of mammary gland epithelial cell proliferation|embryonic heart tube development|embryonic hindlimb morphogenesis|embryonic hemopoiesis|nuclear hormone receptor binding|peroxisome proliferator activated receptor signaling pathway|cellular response to hepatocyte growth factor stimulus|megakaryocyte development|mediator complex binding|mRNA transcription from RNA polymerase II promoter|vitamin D receptor binding|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|negative regulation of apoptotic process|fat cell differentiation|positive regulation of keratinocyte differentiation|positive regulation of erythrocyte differentiation|negative regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|thyroid hormone receptor binding|erythrocyte development|enucleate erythrocyte development|LBD domain binding|regulation of cell cycle|positive regulation of interferon-gamma-mediated signaling pathway|mammary gland branching involved in thelarche|mammary gland branching involved in pregnancy|epithelial cell proliferation involved in mammary gland duct elongation|ubiquitin protein ligase activity|positive regulation of G0 to G1 transition|ERK1 and ERK2 cascade|regulation of vitamin D receptor signaling pathway|cellular response to epidermal growth factor stimulus|cellular response to steroid hormone stimulus|cellular response to thyroid hormone stimulus|positive regulation of receptor activity|positive regulation of hepatocyte proliferation|regulation of RNA biosynthetic process hsa01522,hsa04919 Endocrine resistance|Thyroid hormone signaling pathway MED10 765.772352277196 812.888739320603 718.655965233788 0.884076664457706 -0.177756613690104 0.263100272545113 1 35.9842 36.0415 29.9048 33.3744 GeneID:84246,Genbank:NM_032286.2,HGNC:HGNC:28760,MIM:612382 mediator complex subunit 10 GO:0000151,GO:0001104,GO:0005654,GO:0006367,GO:0016592,GO:0019827,GO:0045944,GO:0061630,GO:0070847 ubiquitin ligase complex|RNA polymerase II transcription cofactor activity|nucleoplasm|transcription initiation from RNA polymerase II promoter|mediator complex|stem cell population maintenance|positive regulation of transcription from RNA polymerase II promoter|ubiquitin protein ligase activity|core mediator complex MED11 373.733506439477 274.492735021642 472.974277857311 1.72308486714601 0.784993760411051 3.35834984402728e-05 0.011205693979571 8.48577 7.89118 12.8606 14.8241 GeneID:400569,Genbank:NM_001305000.1,HGNC:HGNC:32687,MIM:612383 mediator complex subunit 11 GO:0000151,GO:0001104,GO:0006351,GO:0016592,GO:0061630 ubiquitin ligase complex|RNA polymerase II transcription cofactor activity|transcription, DNA-templated|mediator complex|ubiquitin protein ligase activity MED12 1208.00434944662 1194.23462327746 1221.77407561578 1.02306033655492 0.0328912327485869 0.840580948976863 1 6.33165 6.59704 7.03668 6.2373 GeneID:9968,Genbank:NM_005120.2,HGNC:HGNC:11957,MIM:300188 mediator complex subunit 12 GO:0000151,GO:0000980,GO:0001104,GO:0001105,GO:0001843,GO:0003682,GO:0003712,GO:0003713,GO:0004872,GO:0005634,GO:0005654,GO:0006367,GO:0007492,GO:0007507,GO:0008013,GO:0008022,GO:0014003,GO:0014044,GO:0016020,GO:0016592,GO:0019827,GO:0019904,GO:0021510,GO:0030178,GO:0030374,GO:0030518,GO:0030521,GO:0036342,GO:0042809,GO:0045893,GO:0045944,GO:0046966,GO:0048702,GO:0060070,GO:0060071,GO:0061630,GO:0090245,GO:1990403 ubiquitin ligase complex|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II transcription cofactor activity|RNA polymerase II transcription coactivator activity|neural tube closure|chromatin binding|transcription cofactor activity|transcription coactivator activity|receptor activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|endoderm development|heart development|beta-catenin binding|protein C-terminus binding|oligodendrocyte development|Schwann cell development|membrane|mediator complex|stem cell population maintenance|protein domain specific binding|spinal cord development|negative regulation of Wnt signaling pathway|ligand-dependent nuclear receptor transcription coactivator activity|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|post-anal tail morphogenesis|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|thyroid hormone receptor binding|embryonic neurocranium morphogenesis|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|ubiquitin protein ligase activity|axis elongation involved in somitogenesis|embryonic brain development hsa04919 Thyroid hormone signaling pathway MED12L 101.185859591517 105.901415095766 96.4703040872692 0.910944428835366 -0.134565048202511 0.785877811201673 1 0.332888 0.307956 0.378685 0.205471 GeneID:116931,Genbank:XM_017005676.1,HGNC:HGNC:16050,MIM:611318 mediator complex subunit 12 like GO:0001105,GO:0006357,GO:0008013,GO:0016592 RNA polymerase II transcription coactivator activity|regulation of transcription from RNA polymerase II promoter|beta-catenin binding|mediator complex hsa04919 Thyroid hormone signaling pathway MED13 537.977388895602 565.530193848539 510.424583942664 0.902559384971348 -0.147906235923476 0.738634598251621 1 2.24707 1.70742 2.2349 1.37184 GeneID:9969,Genbank:XM_011525551.2,HGNC:HGNC:22474,MIM:603808 mediator complex subunit 13 GO:0001104,GO:0003712,GO:0003713,GO:0004872,GO:0005634,GO:0005654,GO:0006367,GO:0016020,GO:0016592,GO:0030374,GO:0030518,GO:0030521,GO:0042632,GO:0042809,GO:0045893,GO:0045944,GO:0046966,GO:0070328,GO:1904168 RNA polymerase II transcription cofactor activity|transcription cofactor activity|transcription coactivator activity|receptor activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|ligand-dependent nuclear receptor transcription coactivator activity|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|cholesterol homeostasis|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|thyroid hormone receptor binding|triglyceride homeostasis|negative regulation of thyroid hormone receptor activity hsa04919 Thyroid hormone signaling pathway MED13L 1050.04962798955 1067.18166865666 1032.91758732243 0.967892925505963 -0.0470806386951272 0.872292893064487 1 3.9395 3.52336 4.5365 2.95038 GeneID:23389,Genbank:XM_017019090.1,HGNC:HGNC:22962,MIM:608771 mediator complex subunit 13 like GO:0001104,GO:0006351,GO:0016592 RNA polymerase II transcription cofactor activity|transcription, DNA-templated|mediator complex hsa04919 Thyroid hormone signaling pathway MED14 966.960107977708 1016.39755629758 917.522659657834 0.902720253480422 -0.147649118747891 0.508477901828767 1 5.51241 4.9636 5.57221 4.04202 GeneID:9282,Genbank:NM_004229.3,HGNC:HGNC:2370,MIM:300182 mediator complex subunit 14 GO:0001104,GO:0003712,GO:0003713,GO:0004872,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0016020,GO:0016592,GO:0019827,GO:0030374,GO:0030518,GO:0030521,GO:0042809,GO:0045893,GO:0045944,GO:0070847 RNA polymerase II transcription cofactor activity|transcription cofactor activity|transcription coactivator activity|receptor activity|nucleus|nucleoplasm|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|stem cell population maintenance|ligand-dependent nuclear receptor transcription coactivator activity|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|core mediator complex hsa04919 Thyroid hormone signaling pathway MED14OS 8.64443591668238 8.08127380474251 9.20759802862226 1.13937459008242 0.188242137220046 0.928685803874957 1 0.245345 0.365256 0.533312 0.70977 GeneID:100873985,Genbank:NM_001289773.1,HGNC:HGNC:40162 MED14 opposite strand MED15 1536.80772632008 1510.75782900785 1562.85762363231 1.03448586770435 0.0489139364186831 0.754176506026237 1 8.16084 8.37991 8.35217 8.87754 GeneID:51586,Genbank:NM_001003891.2,HGNC:HGNC:14248,MIM:607372 mediator complex subunit 15 GO:0001104,GO:0005634,GO:0005654,GO:0005737,GO:0006367,GO:0016020,GO:0016592 RNA polymerase II transcription cofactor activity|nucleus|nucleoplasm|cytoplasm|transcription initiation from RNA polymerase II promoter|membrane|mediator complex MED16 1415.22577637122 1360.56870829314 1469.8828444493 1.08034444382694 0.111491356995637 0.467335522172916 1 17.9138 19.3063 21.6107 19.4441 GeneID:10025,Genbank:XM_017026121.1,HGNC:HGNC:17556,MIM:604062 mediator complex subunit 16 GO:0003712,GO:0003713,GO:0003824,GO:0004872,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0006367,GO:0016020,GO:0016592,GO:0030375,GO:0030518,GO:0030521,GO:0042809,GO:0045893,GO:0046966 transcription cofactor activity|transcription coactivator activity|catalytic activity|receptor activity|nucleus|nucleoplasm|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|thyroid hormone receptor coactivator activity|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding hsa04919 Thyroid hormone signaling pathway MED17 610.523142670456 648.698253357236 572.348031983676 0.882302409512558 -0.180654870026154 0.281797719427623 1 8.47094 8.26352 7.57583 7.27657 GeneID:9440,Genbank:NM_004268.4,HGNC:HGNC:2375,MIM:603810 mediator complex subunit 17 GO:0001104,GO:0003712,GO:0003713,GO:0004872,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0016020,GO:0016592,GO:0030374,GO:0030518,GO:0030521,GO:0042809,GO:0045893,GO:0045944,GO:0046966 RNA polymerase II transcription cofactor activity|transcription cofactor activity|transcription coactivator activity|receptor activity|nucleus|nucleoplasm|transcription factor complex|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|ligand-dependent nuclear receptor transcription coactivator activity|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|vitamin D receptor binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|thyroid hormone receptor binding hsa04919 Thyroid hormone signaling pathway MED18 435.045751430477 429.131732974395 440.959769886558 1.02756271793321 0.0392264523885375 0.882363940001115 1 6.94168 8.06968 7.42966 9.24703 GeneID:54797,Genbank:NM_017638.2,HGNC:HGNC:25944,MIM:612384 mediator complex subunit 18 GO:0000151,GO:0001104,GO:0006369,GO:0016592,GO:0061630,GO:0070847 ubiquitin ligase complex|RNA polymerase II transcription cofactor activity|termination of RNA polymerase II transcription|mediator complex|ubiquitin protein ligase activity|core mediator complex MED19 438.955807607019 414.64131332463 463.270301889408 1.11727965111548 0.159990332447963 0.390758542779472 1 8.45901 8.8325 9.63091 9.95697 GeneID:219541,Genbank:NM_001317078.1,HGNC:HGNC:29600,MIM:612385 mediator complex subunit 19 GO:0001104,GO:0005634,GO:0006351,GO:0008134,GO:0016592,GO:0016604,GO:0045944 RNA polymerase II transcription cofactor activity|nucleus|transcription, DNA-templated|transcription factor binding|mediator complex|nuclear body|positive regulation of transcription from RNA polymerase II promoter MED20 713.118670517664 693.515264998564 732.722076036763 1.05653345069236 0.0793384448724931 0.631312881216265 1 8.7854 9.30795 9.4319 9.96945 GeneID:9477,Genbank:NM_001305455.1,HGNC:HGNC:16840,MIM:612915 mediator complex subunit 20 GO:0001104,GO:0006351,GO:0016592 RNA polymerase II transcription cofactor activity|transcription, DNA-templated|mediator complex MED21 484.332860174731 494.655188010917 474.010532338544 0.958264552413998 -0.0615040926144076 0.739335043804318 1 8.36518 8.40958 9.21746 7.12689 GeneID:9412,Genbank:NM_004264.4,HGNC:HGNC:11473,MIM:603800 mediator complex subunit 21 GO:0000151,GO:0001104,GO:0001824,GO:0003713,GO:0003899,GO:0006351,GO:0006357,GO:0016592,GO:0019827,GO:0045944,GO:0061630 ubiquitin ligase complex|RNA polymerase II transcription cofactor activity|blastocyst development|transcription coactivator activity|DNA-directed 5'-3' RNA polymerase activity|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|mediator complex|stem cell population maintenance|positive regulation of transcription from RNA polymerase II promoter|ubiquitin protein ligase activity MED22 983.873629490655 986.889444977372 980.857814003938 0.993888240466923 -0.00884446039253444 0.957439488791453 1 12.3343 11.8767 12.1859 12.406 GeneID:6837,Genbank:NM_133640.4,HGNC:HGNC:11477,MIM:185641 mediator complex subunit 22 GO:0001104,GO:0005737,GO:0006351,GO:0016592 RNA polymerase II transcription cofactor activity|cytoplasm|transcription, DNA-templated|mediator complex MED23 387.879224298847 402.070927661408 373.687520936286 0.92940696585498 -0.105617637076841 0.740640047925035 1 3.08707 2.3455 2.90059 2.17648 GeneID:9439,Genbank:NM_001270521.1,HGNC:HGNC:2372,MIM:605042 mediator complex subunit 23 GO:0003713,GO:0005654,GO:0005667,GO:0006355,GO:0006357,GO:0006367 transcription coactivator activity|nucleoplasm|transcription factor complex|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter MED24 2189.75944302912 2104.18590915009 2275.33297690816 1.08133647650326 0.112815512387425 0.437231299556199 1 18.1128 19.6052 21.1623 20.1104 GeneID:9862,Genbank:NM_001330211.1,HGNC:HGNC:22963,MIM:607000 mediator complex subunit 24 GO:0001104,GO:0003712,GO:0004872,GO:0005634,GO:0005654,GO:0006367,GO:0016592,GO:0030374,GO:0030518,GO:0030521,GO:0042809,GO:0045893,GO:0046966 RNA polymerase II transcription cofactor activity|transcription cofactor activity|receptor activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|mediator complex|ligand-dependent nuclear receptor transcription coactivator activity|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding hsa04919 Thyroid hormone signaling pathway MED25 1033.37397606418 1063.57090640104 1003.17704572732 0.943215952683325 -0.0843399759521142 0.562732801025238 1 9.0912 10.0155 9.24554 8.89155 GeneID:81857,Genbank:NM_030973.3,HGNC:HGNC:28845,MIM:610197 mediator complex subunit 25 GO:0000122,GO:0005654,GO:0006367,GO:0008134,GO:0035563,GO:0042974,GO:0044798,GO:0045944,GO:0046965,GO:0048147,GO:0071158,GO:2001178 negative regulation of transcription from RNA polymerase II promoter|nucleoplasm|transcription initiation from RNA polymerase II promoter|transcription factor binding|positive regulation of chromatin binding|retinoic acid receptor binding|nuclear transcription factor complex|positive regulation of transcription from RNA polymerase II promoter|retinoid X receptor binding|negative regulation of fibroblast proliferation|positive regulation of cell cycle arrest|positive regulation of mediator complex assembly MED26 340.673116082833 344.523902226005 336.822329939661 0.977645753352429 -0.0326162907147066 0.851794729820248 1 4.76696 5.11397 5.18217 4.74253 GeneID:9441,Genbank:NM_004831.3,HGNC:HGNC:2376,MIM:605043 mediator complex subunit 26 GO:0001104,GO:0003713,GO:0005654,GO:0006357,GO:0006367,GO:0016592 RNA polymerase II transcription cofactor activity|transcription coactivator activity|nucleoplasm|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|mediator complex MED27 635.840097222073 620.879853305252 650.800341138895 1.04819046337929 0.0679008882556118 0.677118579555648 1 2.79517 2.73306 2.59447 2.83807 GeneID:9442,Genbank:NM_001253881.1,HGNC:HGNC:2377,MIM:605044 mediator complex subunit 27 GO:0000151,GO:0003713,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0006357,GO:0006367,GO:0016592,GO:0019827,GO:0061630 ubiquitin ligase complex|transcription coactivator activity|nucleus|nucleoplasm|transcription factor complex|nucleolus|cytosol|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|mediator complex|stem cell population maintenance|ubiquitin protein ligase activity hsa04919 Thyroid hormone signaling pathway MED28 1004.78685569103 1094.55904058223 915.014670799825 0.835966482276829 -0.258482995670189 0.0899880256273984 0.979717040875575 22.6762 23.4452 20.6314 18.0494 GeneID:80306,Genbank:NM_025205.4,HGNC:HGNC:24628,MIM:610311 mediator complex subunit 28 MED29 1836.23918750947 1683.10602401511 1989.37235100383 1.18196496395284 0.241187271487834 0.0929424039860226 0.987898138646211 16.6025 18.041 20.807 20.5375 GeneID:55588,Genbank:NM_017592.2,HGNC:HGNC:23074,MIM:612914 mediator complex subunit 29 GO:0006351,GO:0006355,GO:0016592 transcription, DNA-templated|regulation of transcription, DNA-templated|mediator complex MED30 142.867593697567 144.231828652063 141.50335874307 0.981082747584275 -0.0275532719036881 0.949040654991022 1 3.79542 3.26452 3.45633 3.31748 GeneID:90390,Genbank:NM_080651.3,HGNC:HGNC:23032,MIM:610237 mediator complex subunit 30 GO:0000151,GO:0001104,GO:0003712,GO:0004872,GO:0005634,GO:0005654,GO:0006367,GO:0016592,GO:0019827,GO:0030374,GO:0030518,GO:0030521,GO:0042809,GO:0045893,GO:0046966,GO:0061630 ubiquitin ligase complex|RNA polymerase II transcription cofactor activity|transcription cofactor activity|receptor activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|mediator complex|stem cell population maintenance|ligand-dependent nuclear receptor transcription coactivator activity|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|ubiquitin protein ligase activity hsa04919 Thyroid hormone signaling pathway MED31 296.706076586586 307.509815396417 285.902337776756 0.929734022987831 -0.105110043826679 0.614716682970365 1 6.88881 8.8776 6.93802 7.98855 GeneID:51003,Genbank:NM_016060.2,HGNC:HGNC:24260 mediator complex subunit 31 GO:0000151,GO:0001104,GO:0003713,GO:0005654,GO:0006357,GO:0006367,GO:0016592,GO:0048147,GO:0060173,GO:0061630,GO:0070847 ubiquitin ligase complex|RNA polymerase II transcription cofactor activity|transcription coactivator activity|nucleoplasm|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|mediator complex|negative regulation of fibroblast proliferation|limb development|ubiquitin protein ligase activity|core mediator complex MED4 561.977402483682 554.961362415287 568.993442552076 1.02528478753137 0.0360246946015373 0.819426300772115 1 6.05218 5.39002 6.6013 5.31114 GeneID:29079,Genbank:NM_001270629.1,HGNC:HGNC:17903,MIM:605718 mediator complex subunit 4 GO:0001104,GO:0003712,GO:0004872,GO:0005634,GO:0005654,GO:0006366,GO:0006367,GO:0016020,GO:0016592,GO:0030374,GO:0030518,GO:0030521,GO:0042809,GO:0045893,GO:0046966,GO:0070847 RNA polymerase II transcription cofactor activity|transcription cofactor activity|receptor activity|nucleus|nucleoplasm|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|membrane|mediator complex|ligand-dependent nuclear receptor transcription coactivator activity|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|vitamin D receptor binding|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|core mediator complex hsa04919 Thyroid hormone signaling pathway MED6 402.862058089178 395.230562345075 410.49355383328 1.03861794340408 0.0546650550872261 0.776703009403872 1 5.73501 6.7528 6.55181 6.28965 GeneID:10001,Genbank:NM_001284210.1,HGNC:HGNC:19970,MIM:602984 mediator complex subunit 6 GO:0001128,GO:0003713,GO:0005634,GO:0005654,GO:0006357,GO:0006367,GO:0008134,GO:0016020,GO:0016592,GO:0045944,GO:0051123,GO:0070847 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly|transcription coactivator activity|nucleus|nucleoplasm|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription factor binding|membrane|mediator complex|positive regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|core mediator complex MED7 170.955371624036 178.113381971167 163.797361276905 0.919624115067451 -0.120883796912973 0.640239298423591 1 4.42066 3.89761 3.82986 4.22022 GeneID:9443,Genbank:NM_004270.4,HGNC:HGNC:2378,MIM:605045 mediator complex subunit 7 GO:0000151,GO:0001104,GO:0003713,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0016592,GO:0016604,GO:0019827,GO:0061630 ubiquitin ligase complex|RNA polymerase II transcription cofactor activity|transcription coactivator activity|nucleoplasm|transcription factor complex|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|mediator complex|nuclear body|stem cell population maintenance|ubiquitin protein ligase activity MED8 1215.33423826287 1261.28612744964 1169.38234907609 0.927134869421437 -0.109148873304694 0.460722442057164 1 21.4837 22.2598 20.0923 20.0376 GeneID:112950,Genbank:NM_052877.4,HGNC:HGNC:19971,MIM:607956 mediator complex subunit 8 GO:0001104,GO:0005654,GO:0006367,GO:0016567,GO:0016592 RNA polymerase II transcription cofactor activity|nucleoplasm|transcription initiation from RNA polymerase II promoter|protein ubiquitination|mediator complex hsa05168 Herpes simplex infection MED9 559.790024606054 526.885247681372 592.694801530736 1.12490301092879 0.169800617723134 0.339503120325881 1 10.8 12.9897 13.9524 13.538 GeneID:55090,Genbank:NM_018019.2,HGNC:HGNC:25487,MIM:609878 mediator complex subunit 9 GO:0001104,GO:0006351,GO:0016592 RNA polymerase II transcription cofactor activity|transcription, DNA-templated|mediator complex MEF2A 715.635071533624 781.754492313649 649.5156507536 0.830843515630232 -0.267351315223993 0.294143929679982 1 2.09733 1.96934 2.06298 1.38302 GeneID:4205,Genbank:XM_011521579.2,HGNC:HGNC:6993,MIM:600660 myocyte enhancer factor 2A GO:0000002,GO:0000122,GO:0000165,GO:0000977,GO:0000981,GO:0003682,GO:0005634,GO:0006351,GO:0006915,GO:0033613,GO:0035035,GO:0042826,GO:0045944,GO:0046332,GO:0046983,GO:0048311,GO:0048813,GO:0055005,GO:0061337,GO:0070375,GO:0071277 mitochondrial genome maintenance|negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|chromatin binding|nucleus|transcription, DNA-templated|apoptotic process|activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|positive regulation of transcription from RNA polymerase II promoter|SMAD binding|protein dimerization activity|mitochondrion distribution|dendrite morphogenesis|ventricular cardiac myofibril assembly|cardiac conduction|ERK5 cascade|cellular response to calcium ion hsa04022,hsa04371,hsa04928,hsa05418 cGMP-PKG signaling pathway|Apelin signaling pathway|Parathyroid hormone synthesis, secretion and action|Fluid shear stress and atherosclerosis MEF2B 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0.417813 0.440776 0.473117 0.578574 GeneID:100271849,Genbank:NM_001145785.1,HGNC:HGNC:6995,MIM:600661 myocyte enhancer factor 2B GO:0000978,GO:0001077,GO:0003700,GO:0005634,GO:0005667,GO:0007517,GO:0042826,GO:0045944,GO:0046983 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription factor complex|muscle organ development|histone deacetylase binding|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity hsa04022,hsa04371 cGMP-PKG signaling pathway|Apelin signaling pathway MEF2C 227.693571425163 221.267057307029 234.120085543297 1.05808830466089 0.0814600351836387 0.828181101305689 1 1.12594 0.778556 1.22518 0.799815 GeneID:4208,Genbank:NM_001131005.2,HGNC:HGNC:6996,MIM:600662 myocyte enhancer factor 2C GO:0000122,GO:0000165,GO:0000977,GO:0000981,GO:0000983,GO:0001077,GO:0001568,GO:0001649,GO:0001782,GO:0001947,GO:0001958,GO:0001974,GO:0002062,GO:0002467,GO:0002634,GO:0003138,GO:0003139,GO:0003151,GO:0003185,GO:0003211,GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0006959,GO:0007507,GO:0007519,GO:0007521,GO:0007611,GO:0010628,GO:0010629,GO:0010694,GO:0014033,GO:0016528,GO:0016607,GO:0030182,GO:0030220,GO:0030279,GO:0030318,GO:0030501,GO:0030890,GO:0035051,GO:0035690,GO:0035984,GO:0042100,GO:0043234,GO:0043524,GO:0044212,GO:0045652,GO:0045663,GO:0045666,GO:0045669,GO:0045893,GO:0045944,GO:0046983,GO:0048643,GO:0048666,GO:0050853,GO:0051145,GO:0055012,GO:0060025,GO:0060045,GO:0061333,GO:0071222,GO:0071277,GO:0071374,GO:0071498,GO:0071560,GO:0072102,GO:0072160,GO:0090073,GO:2000111,GO:2000727,GO:2000987,GO:2001013,GO:2001016 negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|blood vessel development|osteoblast differentiation|B cell homeostasis|heart looping|endochondral ossification|blood vessel remodeling|chondrocyte differentiation|germinal center formation|regulation of germinal center formation|primary heart field specification|secondary heart field specification|outflow tract morphogenesis|sinoatrial valve morphogenesis|cardiac ventricle formation|DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|humoral immune response|heart development|skeletal muscle tissue development|muscle cell fate determination|learning or memory|positive regulation of gene expression|negative regulation of gene expression|positive regulation of alkaline phosphatase activity|neural crest cell differentiation|sarcoplasm|nuclear speck|neuron differentiation|platelet formation|negative regulation of ossification|melanocyte differentiation|positive regulation of bone mineralization|positive regulation of B cell proliferation|cardiocyte differentiation|cellular response to drug|cellular response to trichostatin A|B cell proliferation|protein complex|negative regulation of neuron apoptotic process|transcription regulatory region DNA binding|regulation of megakaryocyte differentiation|positive regulation of myoblast differentiation|positive regulation of neuron differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|positive regulation of skeletal muscle tissue development|neuron development|B cell receptor signaling pathway|smooth muscle cell differentiation|ventricular cardiac muscle cell differentiation|regulation of synaptic activity|positive regulation of cardiac muscle cell proliferation|renal tubule morphogenesis|cellular response to lipopolysaccharide|cellular response to calcium ion|cellular response to parathyroid hormone stimulus|cellular response to fluid shear stress|cellular response to transforming growth factor beta stimulus|glomerulus morphogenesis|nephron tubule epithelial cell differentiation|positive regulation of protein homodimerization activity|positive regulation of macrophage apoptotic process|positive regulation of cardiac muscle cell differentiation|positive regulation of behavioral fear response|epithelial cell proliferation involved in renal tubule morphogenesis|positive regulation of skeletal muscle cell differentiation hsa04010,hsa04022,hsa04371,hsa04921,hsa04928,hsa05202,hsa05418 MAPK signaling pathway|cGMP-PKG signaling pathway|Apelin signaling pathway|Oxytocin signaling pathway|Parathyroid hormone synthesis, secretion and action|Transcriptional misregulation in cancer|Fluid shear stress and atherosclerosis MEF2D 793.19203566369 841.503968732015 744.880102595365 0.885177171199508 -0.175961850506181 0.271594496170285 1 2.83943 2.59846 2.52882 2.33178 GeneID:4209,Genbank:NM_005920.3,HGNC:HGNC:6997,MIM:600663 myocyte enhancer factor 2D hsa04022,hsa04371,hsa04928 cGMP-PKG signaling pathway|Apelin signaling pathway|Parathyroid hormone synthesis, secretion and action MEFV 1.2378804854154 0.538097676642304 1.93766329418849 3.60095086505369 1.84837791409998 0.680650629779701 1 0.0111782 0 0.0104542 0.029278 GeneID:4210,Genbank:NM_001198536.1,HGNC:HGNC:6998,MIM:608107 MEFV, pyrin innate immunity regulator hsa04621 NOD-like receptor signaling pathway MEGF10 53.6199377328722 42.2990110466411 64.9408644191032 1.53528091584685 0.618502654826401 0.111640448672585 1 0.196373 0.127751 0.293567 0.259606 GeneID:84466,Genbank:XM_017009987.1,HGNC:HGNC:29634,MIM:612453 multiple EGF like domains 10 GO:0001849,GO:0001891,GO:0005044,GO:0005112,GO:0005886,GO:0014719,GO:0014816,GO:0014841,GO:0016021,GO:0033002,GO:0034109,GO:0042995,GO:0043652,GO:0043654,GO:0048641,GO:0051147,GO:0051451,GO:0055001,GO:1902742 complement component C1q binding|phagocytic cup|scavenger receptor activity|Notch binding|plasma membrane|skeletal muscle satellite cell activation|skeletal muscle satellite cell differentiation|skeletal muscle satellite cell proliferation|integral component of membrane|muscle cell proliferation|homotypic cell-cell adhesion|cell projection|engulfment of apoptotic cell|recognition of apoptotic cell|regulation of skeletal muscle tissue development|regulation of muscle cell differentiation|myoblast migration|muscle cell development|apoptotic process involved in development MEGF11 16.6657953217788 18.7952010629037 14.5363895806539 0.773409634299929 -0.370695358821752 0.652228984051223 1 0.0663884 0.0227326 0.0346026 0.0376604 GeneID:84465,Genbank:XM_017022672.2,HGNC:HGNC:29635,MIM:612454 multiple EGF like domains 11 GO:0010842,GO:0016021,GO:0016323,GO:0034109 retina layer formation|integral component of membrane|basolateral plasma membrane|homotypic cell-cell adhesion MEGF6 431.522405682027 481.145928165922 381.898883198132 0.793727767070358 -0.333283818554959 0.0602343650790213 0.879410748501007 2.12849 2.38918 1.94548 1.73867 GeneID:1953,Genbank:NM_001409.3,HGNC:HGNC:3232,MIM:604266 multiple EGF like domains 6 GO:0005509,GO:0005576 calcium ion binding|extracellular region MEGF8 3188.38563748682 3110.00380835845 3266.76746661519 1.05040625925776 0.0709474182334093 0.608300050518075 1 12.4948 11.9518 12.7772 13.3971 GeneID:1954,Genbank:NM_001271938.1,HGNC:HGNC:3233,MIM:604267 multiple EGF like domains 8 GO:0003143,GO:0005509,GO:0005634,GO:0010468,GO:0016021,GO:0030326,GO:0030509,GO:0035108,GO:0042074,GO:0048704,GO:0048842,GO:0055113,GO:0060971,GO:0060972,GO:0060976,GO:0061371,GO:0070062,GO:0071907,GO:0097094,GO:0097155 embryonic heart tube morphogenesis|calcium ion binding|nucleus|regulation of gene expression|integral component of membrane|embryonic limb morphogenesis|BMP signaling pathway|limb morphogenesis|cell migration involved in gastrulation|embryonic skeletal system morphogenesis|positive regulation of axon extension involved in axon guidance|epiboly involved in gastrulation with mouth forming second|embryonic heart tube left/right pattern formation|left/right pattern formation|coronary vasculature development|determination of heart left/right asymmetry|extracellular exosome|determination of digestive tract left/right asymmetry|craniofacial suture morphogenesis|fasciculation of sensory neuron axon MEGF9 337.281938331569 349.865644371996 324.698232291142 0.928065494609997 -0.107701473354686 0.598042514068367 1 2.5924 2.39239 2.34927 2.29437 GeneID:1955,Genbank:NM_001080497.2,HGNC:HGNC:3234,MIM:604268 multiple EGF like domains 9 GO:0005604,GO:0016021 basement membrane|integral component of membrane MEI1 1.45389994968141 0 2.90779989936283 Inf Inf 0.254628784757125 1 0 0 0.0094108 0 GeneID:150365,Genbank:XM_011529945.3,HGNC:HGNC:28613,MIM:608797 meiotic double-stranded break formation protein 1 GO:0005623,GO:0007127,GO:0007141,GO:0007286,GO:0045141 cell|meiosis I|male meiosis I|spermatid development|meiotic telomere clustering MEIG1 4.60914163942773 6.31309329565283 2.90518998320264 0.460184864558099 -1.1197145606649 0.541433241074435 1 0 0.0601757 0 0.0568997 GeneID:644890,Genbank:XM_024448136.1,HGNC:HGNC:23429,MIM:614174 meiosis/spermiogenesis associated 1 GO:0005634,GO:0007283,GO:0030154 nucleus|spermatogenesis|cell differentiation MEIOB 1.48248120036738 1.02816907859967 1.93679332213509 1.88373037319206 0.913592480292383 0.868302647456973 1 0 0 0 0.0205667 GeneID:254528,Genbank:NM_001163560.2,HGNC:HGNC:28569,MIM:617670 meiosis specific with OB domains GO:0000712,GO:0000724,GO:0003682,GO:0003697,GO:0005634,GO:0005694,GO:0005737,GO:0007129,GO:0007140,GO:0007144,GO:0008310,GO:0009566 resolution of meiotic recombination intermediates|double-strand break repair via homologous recombination|chromatin binding|single-stranded DNA binding|nucleus|chromosome|cytoplasm|synapsis|male meiotic nuclear division|female meiosis I|single-stranded DNA 3'-5' exodeoxyribonuclease activity|fertilization MEIOC 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.00826479 0 0 0 GeneID:284071,Genbank:NM_001145080.2,HGNC:HGNC:26670,MIM:616934 meiosis specific with coiled-coil domain GO:0005634,GO:0005737,GO:0006302,GO:0007130,GO:0007141,GO:0007144,GO:0007286,GO:0048255,GO:0048599,GO:0051310,GO:0051729,GO:0070192 nucleus|cytoplasm|double-strand break repair|synaptonemal complex assembly|male meiosis I|female meiosis I|spermatid development|mRNA stabilization|oocyte development|metaphase plate congression|germline cell cycle switching, mitotic to meiotic cell cycle|chromosome organization involved in meiotic cell cycle MEIS1 102.277116221612 100.856622252137 103.697610191087 1.02816858105606 0.0400768317630435 0.896330027598553 1 1.02351 0.890435 0.74937 1.11703 GeneID:4211,Genbank:NM_002398.2,HGNC:HGNC:7000,MIM:601739 Meis homeobox 1 hsa04550,hsa05202 Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer MEIS2 3190.64246077701 3123.34835506832 3257.93656648569 1.04309100238498 0.0608650283872487 0.646550497398636 1 20.2331 19.6009 23.5032 18.5583 GeneID:4212,Genbank:NM_002399.3,HGNC:HGNC:7001,MIM:601740 Meis homeobox 2 GO:0000122,GO:0000978,GO:0001077,GO:0001654,GO:0003700,GO:0003712,GO:0003714,GO:0005634,GO:0006366,GO:0008134,GO:0008542,GO:0009612,GO:0031016,GO:0043565,GO:0045638,GO:0045931,GO:0045944,GO:0048471,GO:0070848,GO:0110024 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|eye development|DNA binding transcription factor activity|transcription cofactor activity|transcription corepressor activity|nucleus|transcription from RNA polymerase II promoter|transcription factor binding|visual learning|response to mechanical stimulus|pancreas development|sequence-specific DNA binding|negative regulation of myeloid cell differentiation|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|perinuclear region of cytoplasm|response to growth factor|positive regulation of cardiac muscle myoblast proliferation MEIS3 880.575101050573 815.176417196974 945.973784904171 1.16045283566587 0.2146878883578 0.177510444315128 1 6.2458 6.80948 7.78218 8.22405 GeneID:56917,Genbank:NM_001346148.1,HGNC:HGNC:29537 Meis homeobox 3 GO:0001077,GO:0003682,GO:0005634,GO:0043565,GO:0051897,GO:2001234 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|chromatin binding|nucleus|sequence-specific DNA binding|positive regulation of protein kinase B signaling|negative regulation of apoptotic signaling pathway MELK 3776.80680680214 3875.97589525668 3677.6377183476 0.948828841492073 -0.0757802308242944 0.592398032036888 1 41.0128 37.8715 41.4226 33.3072 GeneID:9833,Genbank:NM_014791.3,HGNC:HGNC:16870,MIM:607025 maternal embryonic leucine zipper kinase MELTF 104.607116332183 113.252486125126 95.9617465392403 0.847325739350373 -0.239011400178424 0.416426937396738 1 0.82351 0.791782 0.822549 0.684495 GeneID:4241,Genbank:NM_005929.5,HGNC:HGNC:7037,MIM:155750 melanotransferrin GO:0005506,GO:0005576,GO:0005788,GO:0005886,GO:0005887,GO:0006501,GO:0009986,GO:0010756,GO:0043687,GO:0044267,GO:0046658,GO:0055072,GO:0070062,GO:0090091,GO:0097286,GO:1900025 iron ion binding|extracellular region|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|C-terminal protein lipidation|cell surface|positive regulation of plasminogen activation|post-translational protein modification|cellular protein metabolic process|anchored component of plasma membrane|iron ion homeostasis|extracellular exosome|positive regulation of extracellular matrix disassembly|iron ion import|negative regulation of substrate adhesion-dependent cell spreading MEMO1 574.770070453451 531.602648256459 617.937492650443 1.1624048425589 0.217112618339032 0.204692240716791 1 9.25323 9.35509 11.3651 9.73461 GeneID:51072,Genbank:XM_024452944.1,HGNC:HGNC:14014,MIM:611786 mediator of cell motility 1 GO:0005634,GO:0005829,GO:0032886,GO:2000145 nucleus|cytosol|regulation of microtubule-based process|regulation of cell motility MEN1 807.83103565875 786.982598601764 828.679472715736 1.05298322248555 0.0744824496307444 0.64353362456648 1 7.57993 7.43888 8.06071 8.59784 GeneID:4221,Genbank:NM_130804.2,HGNC:HGNC:7010,MIM:613733 menin 1 hsa04934,hsa05202 Cushing syndrome|Transcriptional misregulation in cancer MEOX1 4.70076805756809 8.9173377846024 0.484198330533773 0.0542985296990588 -4.20294305665476 0.174999092658761 1 0.0284614 0.167662 0 0 GeneID:4222,Genbank:NM_001040002.1,HGNC:HGNC:7013,MIM:600147 mesenchyme homeobox 1 GO:0000978,GO:0001046,GO:0001077,GO:0001757,GO:0003682,GO:0003700,GO:0005634,GO:0005737,GO:0007275,GO:0043565,GO:0045944,GO:0060218,GO:0061053,GO:0061056,GO:0071837 RNA polymerase II proximal promoter sequence-specific DNA binding|core promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|somite specification|chromatin binding|DNA binding transcription factor activity|nucleus|cytoplasm|multicellular organism development|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|hematopoietic stem cell differentiation|somite development|sclerotome development|HMG box domain binding MEOX2 1.02229600717608 1.07619535328461 0.968396661067546 0.899833527539349 -0.152269972565186 1 1 0.0363777 0 0 0.0321442 GeneID:4223,Genbank:NM_005924.4,HGNC:HGNC:7014,MIM:600535 mesenchyme homeobox 2 GO:0000978,GO:0000980,GO:0001077,GO:0001205,GO:0001525,GO:0001757,GO:0003700,GO:0005634,GO:0005737,GO:0007275,GO:0007519,GO:0008015,GO:0016607,GO:0043565,GO:0045944,GO:0060021,GO:0060173,GO:0061053,GO:0070997,GO:0090051 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|angiogenesis|somite specification|DNA binding transcription factor activity|nucleus|cytoplasm|multicellular organism development|skeletal muscle tissue development|blood circulation|nuclear speck|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|palate development|limb development|somite development|neuron death|negative regulation of cell migration involved in sprouting angiogenesis MEP1A 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0110238 0 0 0 GeneID:4224,Genbank:NM_005588.2,HGNC:HGNC:7015,MIM:600388 meprin A subunit alpha GO:0004222,GO:0005615,GO:0005887,GO:0007586,GO:0008270,GO:0017090,GO:0070062 metalloendopeptidase activity|extracellular space|integral component of plasma membrane|digestion|zinc ion binding|meprin A complex|extracellular exosome hsa04974 Protein digestion and absorption MEP1B 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00834703 GeneID:4225,Genbank:NM_005925.2,HGNC:HGNC:7020,MIM:600389 meprin A subunit beta GO:0004222,GO:0005615,GO:0005886,GO:0005887,GO:0006954,GO:0007586,GO:0008270,GO:0042802,GO:1901998 metalloendopeptidase activity|extracellular space|plasma membrane|integral component of plasma membrane|inflammatory response|digestion|zinc ion binding|identical protein binding|toxin transport hsa04974 Protein digestion and absorption MEPCE 3073.64761543514 3202.8302340831 2944.46499678717 0.919332209822888 -0.121341806977245 0.355576113848517 1 36.1551 39.6904 34.686 36.4477 GeneID:56257,Genbank:NM_001194990.1,HGNC:HGNC:20247,MIM:611478 methylphosphate capping enzyme GO:0000122,GO:0001510,GO:0003723,GO:0008173,GO:0008757,GO:0016073,GO:0035562,GO:0040031,GO:1900087 negative regulation of transcription from RNA polymerase II promoter|RNA methylation|RNA binding|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|snRNA metabolic process|negative regulation of chromatin binding|snRNA modification|positive regulation of G1/S transition of mitotic cell cycle MERTK 43.5114254566515 41.9628271238466 45.0600237894564 1.07380810297812 0.102736196658732 0.843467445280978 1 0.215959 0.276999 0.249667 0.357164 GeneID:10461,Genbank:XM_005263565.4,HGNC:HGNC:7027,MIM:604705 MER proto-oncogene, tyrosine kinase MESD 1650.12649182334 1175.57267538265 2124.68030826404 1.80735768426437 0.853882050335755 3.08813488740353e-09 5.49550759518388e-06 10.8489 10.5784 21.2054 18.5323 GeneID:23184,Genbank:NM_015154.2,HGNC:HGNC:13520,MIM:607783 mesoderm development LRP chaperone GO:0005783,GO:0005886,GO:0006457,GO:0006909,GO:0007498,GO:0016055,GO:0034394,GO:0042802,GO:0050750,GO:1904395 endoplasmic reticulum|plasma membrane|protein folding|phagocytosis|mesoderm development|Wnt signaling pathway|protein localization to cell surface|identical protein binding|low-density lipoprotein particle receptor binding|positive regulation of skeletal muscle acetylcholine-gated channel clustering MESP1 33.4430937601877 32.9592454449822 33.9269420753932 1.0293604000136 0.0417481875571121 0.994756069894286 1 1.89231 2.68386 2.75177 2.14788 GeneID:55897,Genbank:NM_018670.3,HGNC:HGNC:29658,MIM:608689 mesoderm posterior bHLH transcription factor 1 GO:0000978,GO:0001077,GO:0001707,GO:0001756,GO:0001947,GO:0003139,GO:0003143,GO:0003210,GO:0003211,GO:0003236,GO:0003241,GO:0003259,GO:0003700,GO:0005634,GO:0007219,GO:0007369,GO:0008078,GO:0009880,GO:0022008,GO:0023019,GO:0035326,GO:0035481,GO:0042662,GO:0042664,GO:0044212,GO:0045446,GO:0045747,GO:0045892,GO:0045893,GO:0045944,GO:0046983,GO:0048368,GO:0051155,GO:0055007,GO:0060913,GO:0060921,GO:0060947,GO:0060975,GO:0070368,GO:0090082 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|mesoderm formation|somitogenesis|heart looping|secondary heart field specification|embryonic heart tube morphogenesis|cardiac atrium formation|cardiac ventricle formation|sinus venosus morphogenesis|growth involved in heart morphogenesis|cardioblast anterior-lateral migration|DNA binding transcription factor activity|nucleus|Notch signaling pathway|gastrulation|mesodermal cell migration|embryonic pattern specification|neurogenesis|signal transduction involved in regulation of gene expression|enhancer binding|positive regulation of Notch signaling pathway involved in heart induction|negative regulation of mesodermal cell fate specification|negative regulation of endodermal cell fate specification|transcription regulatory region DNA binding|endothelial cell differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|lateral mesoderm development|positive regulation of striated muscle cell differentiation|cardiac muscle cell differentiation|cardiac cell fate determination|sinoatrial node cell differentiation|cardiac vascular smooth muscle cell differentiation|cardioblast migration to the midline involved in heart field formation|positive regulation of hepatocyte differentiation|positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway MESP2 1.75533654645372 2.05633815719933 1.45433493570811 0.707245027096551 -0.499717967356846 0.969172040919743 1 0.0852694 0.0357305 0.0777379 0.0363887 GeneID:145873,Genbank:NM_001039958.1,HGNC:HGNC:29659,MIM:605195 mesoderm posterior bHLH transcription factor 2 GO:0000978,GO:0001077,GO:0001707,GO:0001756,GO:0003007,GO:0005634,GO:0007219,GO:0009880,GO:0046983,GO:0070062 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|mesoderm formation|somitogenesis|heart morphogenesis|nucleus|Notch signaling pathway|embryonic pattern specification|protein dimerization activity|extracellular exosome MEST 2940.00153331348 3324.34323945403 2555.65982717293 0.768771346123889 -0.379373530335734 0.00537389250747064 0.285941071095182 45.6727 46.5647 40.0848 31.5039 GeneID:4232,Genbank:NM_177524.2,HGNC:HGNC:7028,MIM:601029 mesoderm specific transcript GO:0005783,GO:0005789,GO:0007498,GO:0016021,GO:0016787,GO:0070062 endoplasmic reticulum|endoplasmic reticulum membrane|mesoderm development|integral component of membrane|hydrolase activity|extracellular exosome MET 4515.03194523079 4940.44745821991 4089.61643224166 0.827782597998762 -0.272676174955034 0.353714933677893 1 24.3524 22.37 24.253 14.9648 GeneID:4233,Genbank:NM_001324402.1,HGNC:HGNC:7029,MIM:164860 MET proto-oncogene, receptor tyrosine kinase hsa01521,hsa04010,hsa04014,hsa04015,hsa04151,hsa04360,hsa04510,hsa04520,hsa05100,hsa05120,hsa05144,hsa05200,hsa05202,hsa05205,hsa05206,hsa05211,hsa05218,hsa05225,hsa05226,hsa05230 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Axon guidance|Focal adhesion|Adherens junction|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Malaria|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Renal cell carcinoma|Melanoma|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer METAP1 1292.43114376401 1370.35727667462 1214.5050108534 0.886268881499707 -0.174183636336822 0.245616357541141 1 10.0439 9.6879 9.08547 8.36926 GeneID:23173,Genbank:NM_015143.2,HGNC:HGNC:15789,MIM:610151 methionyl aminopeptidase 1 GO:0004177,GO:0005737,GO:0005829,GO:0006417,GO:0008235,GO:0018206,GO:0022400,GO:0031365,GO:0046872,GO:0070527 aminopeptidase activity|cytoplasm|cytosol|regulation of translation|metalloexopeptidase activity|peptidyl-methionine modification|regulation of rhodopsin mediated signaling pathway|N-terminal protein amino acid modification|metal ion binding|platelet aggregation METAP1D 196.369627142462 208.574244131677 184.165010153246 0.882971005935799 -0.179562029923484 0.444221328162181 1 2.11035 2.04636 1.84103 1.71869 GeneID:254042,Genbank:NM_001322279.1,HGNC:HGNC:32583,MIM:610267 methionyl aminopeptidase type 1D, mitochondrial GO:0004177,GO:0005739,GO:0008235,GO:0018206,GO:0031365,GO:0043231,GO:0046872 aminopeptidase activity|mitochondrion|metalloexopeptidase activity|peptidyl-methionine modification|N-terminal protein amino acid modification|intracellular membrane-bounded organelle|metal ion binding METAP2 806.691302145911 907.247937831746 706.134666460075 0.778326008817042 -0.361553527351167 0.0252308294773198 0.631315976879816 9.55254 8.45201 7.56108 6.56737 GeneID:10988,Genbank:NM_006838.3,HGNC:HGNC:16672,MIM:601870 methionyl aminopeptidase 2 METRN 1275.47294465103 1120.90824342919 1430.03764587288 1.27578475245928 0.351384941364061 0.0317310244353846 0.706820705642726 16.6586 17.0431 19.9574 22.3441 GeneID:79006,Genbank:NM_024042.3,HGNC:HGNC:14151,MIM:610998 meteorin, glial cell differentiation regulator GO:0005615,GO:0010001,GO:0050772 extracellular space|glial cell differentiation|positive regulation of axonogenesis METRNL 485.435724560785 500.815410828262 470.056038293308 0.938581417684245 -0.0914461971465528 0.590683846988732 1 9.74302 10.1746 9.1314 10.1342 GeneID:284207,Genbank:NM_001004431.2,HGNC:HGNC:27584,MIM:616241 meteorin like, glial cell differentiation regulator GO:0005179,GO:0005615,GO:0009409,GO:0014850,GO:0045444,GO:0050728,GO:0050873,GO:0070062,GO:0090336,GO:2000507 hormone activity|extracellular space|response to cold|response to muscle activity|fat cell differentiation|negative regulation of inflammatory response|brown fat cell differentiation|extracellular exosome|positive regulation of brown fat cell differentiation|positive regulation of energy homeostasis METTL1 346.408899240753 392.838040265081 299.979758216425 0.763621970046492 -0.389069483998371 0.0412206482145817 0.759435523043776 5.95262 6.49886 4.63797 4.22694 GeneID:4234,Genbank:NM_023033.3,HGNC:HGNC:7030,MIM:604466 methyltransferase like 1 GO:0000049,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006400,GO:0008176,GO:0043527 tRNA binding|nucleus|nucleoplasm|nucleolus|cytosol|tRNA modification|tRNA (guanine-N7-)-methyltransferase activity|tRNA methyltransferase complex METTL13 1511.69458131988 1540.45906242765 1482.93010021211 0.962654663393078 -0.0549097472473637 0.693585394811803 1 17.6109 18.3729 17.6667 17.4502 GeneID:51603,Genbank:NM_015935.4,HGNC:HGNC:24248 methyltransferase like 13 GO:0008168 methyltransferase activity METTL14 166.400236177066 170.426127019012 162.37434533512 0.952755004031781 -0.0698228145496025 0.806917498642225 1 1.55477 1.43375 1.74317 1.23385 GeneID:57721,Genbank:NM_020961.3,HGNC:HGNC:29330,MIM:616504 methyltransferase like 14 GO:0000398,GO:0001510,GO:0003729,GO:0005634,GO:0007283,GO:0016422,GO:0019827,GO:0021861,GO:0036396,GO:0042063,GO:0061157,GO:0080009 mRNA splicing, via spliceosome|RNA methylation|mRNA binding|nucleus|spermatogenesis|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|stem cell population maintenance|forebrain radial glial cell differentiation|RNA N6-methyladenosine methyltransferase complex|gliogenesis|mRNA destabilization|mRNA methylation METTL15 195.338191042089 190.518037498409 200.158344585768 1.05060049543834 0.0712141699462741 0.813950947486819 1 1.58129 0.954807 1.37996 1.15781 GeneID:196074,Genbank:XM_011519941.2,HGNC:HGNC:26606 methyltransferase like 15 GO:0070475,GO:0071424 rRNA base methylation|rRNA (cytosine-N4-)-methyltransferase activity METTL16 1007.78776111447 1066.63477932577 948.940742903165 0.889658542264114 -0.168676369938307 0.271822277756786 1 6.84819 6.72549 6.49865 5.63674 GeneID:79066,Genbank:NM_024086.3,HGNC:HGNC:28484 methyltransferase like 16 GO:0003723,GO:0005634,GO:0006397,GO:0008380,GO:0010608,GO:0016422,GO:0030629,GO:0035613,GO:0048024,GO:0052907,GO:0070475,GO:0120048,GO:0120049 RNA binding|nucleus|mRNA processing|RNA splicing|posttranscriptional regulation of gene expression|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|U6 snRNA 3'-end binding|RNA stem-loop binding|regulation of mRNA splicing, via spliceosome|23S rRNA (adenine(1618)-N(6))-methyltransferase activity|rRNA base methylation|U6 snRNA (adenine-(43)-N(6))-methyltransferase activity|snRNA (adenine-N6)-methylation METTL17 954.912421927661 935.770165696353 974.05467815897 1.04091230289879 0.0578485263678316 0.727812281652688 1 16.4391 17.7684 17.5725 19.0422 GeneID:64745,Genbank:NM_001029991.1,HGNC:HGNC:19280,MIM:616091 methyltransferase like 17 GO:0005634,GO:0005654,GO:0005739,GO:0005840,GO:0006412,GO:0008168 nucleus|nucleoplasm|mitochondrion|ribosome|translation|methyltransferase activity METTL18 61.7934704854142 63.0064714426893 60.580469528139 0.961495988284997 -0.0566472567641178 0.92215912305906 1 0.965015 0.806559 0.915117 0.85079 GeneID:92342,Genbank:XM_006711627.3,HGNC:HGNC:28793,MIM:615255 methyltransferase like 18 GO:0008168,GO:0031072,GO:0043234 methyltransferase activity|heat shock protein binding|protein complex METTL21A 273.242880988455 270.244771537442 276.240990439469 1.02218810328102 0.0316607057665897 0.856265157039368 1 2.1027 1.72842 1.87246 1.77083 GeneID:151194,Genbank:NM_001330132.1,HGNC:HGNC:30476,MIM:615257 methyltransferase like 21A GO:0005654,GO:0005737,GO:0006479,GO:0008276,GO:0016279,GO:0018022,GO:0030544,GO:0031072,GO:0043234,GO:0051117 nucleoplasm|cytoplasm|protein methylation|protein methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|Hsp70 protein binding|heat shock protein binding|protein complex|ATPase binding METTL21C 3.30009171403832 5.6309167949557 0.969266633120943 0.172133005763686 -2.53840434041397 0.190445200252263 1 0.0081858 0.0119423 0.00396115 0.00368376 GeneID:196541,Genbank:XM_017020408.2,HGNC:HGNC:33717,MIM:615259 methyltransferase like 21C GO:0005634,GO:0006479,GO:0007519,GO:0008628,GO:0010880,GO:0016279,GO:0031072,GO:0043234,GO:0071549 nucleus|protein methylation|skeletal muscle tissue development|hormone-mediated apoptotic signaling pathway|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|protein-lysine N-methyltransferase activity|heat shock protein binding|protein complex|cellular response to dexamethasone stimulus METTL22 194.518707273507 183.081739575641 205.955674971373 1.12493837697167 0.169845974178007 0.477804914460398 1 0.474708 0.526731 0.577374 0.605299 GeneID:79091,Genbank:NM_024109.3,HGNC:HGNC:28368,MIM:615261 methyltransferase like 22 GO:0005634,GO:0005654,GO:0005730,GO:0006479,GO:0008276,GO:0016279,GO:0031072,GO:0043234 nucleus|nucleoplasm|nucleolus|protein methylation|protein methyltransferase activity|protein-lysine N-methyltransferase activity|heat shock protein binding|protein complex METTL23 719.144281010241 680.841052132574 757.447509887908 1.11251738936038 0.153827886504133 0.347973897474562 1 12.1864 12.7434 13.7739 13.5019 GeneID:124512,Genbank:XM_006721674.3,HGNC:HGNC:26988,MIM:615262 methyltransferase like 23 GO:0005634,GO:0005737,GO:0008134,GO:0008168,GO:0016021,GO:0031072,GO:0043234,GO:0045944,GO:0050890 nucleus|cytoplasm|transcription factor binding|methyltransferase activity|integral component of membrane|heat shock protein binding|protein complex|positive regulation of transcription from RNA polymerase II promoter|cognition METTL24 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0149013 0 0 GeneID:728464,Genbank:NM_001354594.1,HGNC:HGNC:21566 methyltransferase like 24 GO:0005576,GO:0008168 extracellular region|methyltransferase activity METTL25 44.6172887656256 44.1632441051007 45.0713334261505 1.02056210632735 0.0293639802776403 0.971693280664654 1 0.066455 0.0792828 0.0835363 0.072572 GeneID:84190,Genbank:XM_011538827.3,HGNC:HGNC:26228 methyltransferase like 25 GO:0008168 methyltransferase activity METTL26 603.267703019528 618.23840819758 588.296997841476 0.951569799030449 -0.0716186107245883 0.652519621298239 1 15.6433 18.7801 16.0642 17.5638 GeneID:84326,Genbank:NM_001040161.2,HGNC:HGNC:14141 methyltransferase like 26 METTL27 171.775589054448 151.640734611216 191.91044349768 1.26555996968564 0.33977587245704 0.161619781692644 1 3.4274 3.31687 5.00925 4.6121 GeneID:155368,Genbank:XM_017011777.1,HGNC:HGNC:19068,MIM:612546 methyltransferase like 27 METTL2A 782.561842335624 802.808962288454 762.314722382794 0.949559307621293 -0.0746699837816489 0.633124621158336 1 10.1328 11.2038 10.0434 9.85924 GeneID:339175,Genbank:XM_017024572.2,HGNC:HGNC:25755 methyltransferase like 2A GO:0016427,GO:0030488 tRNA (cytosine) methyltransferase activity|tRNA methylation METTL2B 1415.1403824179 1455.92766691841 1374.35309791739 0.94397072680562 -0.0831859735917533 0.563061965103081 1 20.9888 22.4852 19.658 20.3346 GeneID:55798,Genbank:NM_018396.2,HGNC:HGNC:18272,MIM:607846 methyltransferase like 2B GO:0016427,GO:0030488 tRNA (cytosine) methyltransferase activity|tRNA methylation METTL3 811.277927519731 796.332172858531 826.223682180932 1.03753648331839 0.0531620674254451 0.741820817390322 1 11.8866 12.0665 11.5618 13.6368 GeneID:56339,Genbank:NM_019852.4,HGNC:HGNC:17563,MIM:612472 methyltransferase like 3 GO:0000398,GO:0001510,GO:0003729,GO:0005634,GO:0005654,GO:0006382,GO:0006397,GO:0006402,GO:0006974,GO:0007283,GO:0007623,GO:0008173,GO:0016070,GO:0016422,GO:0016607,GO:0019827,GO:0021861,GO:0031053,GO:0034644,GO:0036396,GO:0042063,GO:0045580,GO:0045746,GO:0046982,GO:0051445,GO:0061157,GO:0080009,GO:0098508,GO:1902036,GO:1903679,GO:1904047,GO:1990744 mRNA splicing, via spliceosome|RNA methylation|mRNA binding|nucleus|nucleoplasm|adenosine to inosine editing|mRNA processing|mRNA catabolic process|cellular response to DNA damage stimulus|spermatogenesis|circadian rhythm|RNA methyltransferase activity|RNA metabolic process|mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity|nuclear speck|stem cell population maintenance|forebrain radial glial cell differentiation|primary miRNA processing|cellular response to UV|RNA N6-methyladenosine methyltransferase complex|gliogenesis|regulation of T cell differentiation|negative regulation of Notch signaling pathway|protein heterodimerization activity|regulation of meiotic cell cycle|mRNA destabilization|mRNA methylation|endothelial to hematopoietic transition|regulation of hematopoietic stem cell differentiation|positive regulation of cap-independent translational initiation|S-adenosyl-L-methionine binding|primary miRNA methylation METTL4 338.00782182207 351.287832303183 324.727811340958 0.92439242547034 -0.113422656567268 0.574976193236301 1 3.81521 3.71697 4.11588 3.08106 GeneID:64863,Genbank:NM_001308401.1,HGNC:HGNC:24726 methyltransferase like 4 GO:0003676,GO:0005634,GO:0009007 nucleic acid binding|nucleus|site-specific DNA-methyltransferase (adenine-specific) activity METTL5 487.755628740485 500.103808362241 475.407449118728 0.950617534138782 -0.0730630824941472 0.681244642764465 1 15.7528 15.9058 16.0232 16.2884 GeneID:29081,Genbank:NM_001293187.1,HGNC:HGNC:25006 methyltransferase like 5 GO:0003676,GO:0008168 nucleic acid binding|methyltransferase activity METTL6 709.665254206231 704.535950214196 714.794558198266 1.01456080130609 0.0208553265182535 0.883414614079996 1 1.81808 1.70666 1.70312 1.86771 GeneID:131965,Genbank:XM_017005719.1,HGNC:HGNC:28343 methyltransferase like 6 GO:0008168 methyltransferase activity METTL7A 1390.49577240499 1205.4081789714 1575.58336583858 1.3070953004343 0.386364331991531 0.00769550374908195 0.342738246075193 18.2668 16.9679 24.8406 21.8694 GeneID:25840,Genbank:NM_014033.3,HGNC:HGNC:24550 methyltransferase like 7A GO:0005576,GO:0005783,GO:0005811,GO:0008168,GO:0016020,GO:0043312,GO:0070062,GO:1904724 extracellular region|endoplasmic reticulum|lipid droplet|methyltransferase activity|membrane|neutrophil degranulation|extracellular exosome|tertiary granule lumen METTL7B 220.879562734909 175.730668546281 266.028456923536 1.51384194417649 0.59821458560361 0.0218195125834021 0.600929980812952 4.52929 4.49569 6.17704 7.57042 GeneID:196410,Genbank:NM_152637.2,HGNC:HGNC:28276 methyltransferase like 7B GO:0008168 methyltransferase activity METTL8 186.815281213482 199.628497382606 174.002065044357 0.871629388217388 -0.198213255110091 0.392154628831186 1 0.683186 0.824841 0.711161 0.540279 GeneID:79828,Genbank:NM_001321161.1,HGNC:HGNC:25856,MIM:609525 methyltransferase like 8 GO:0005634,GO:0005737,GO:0008168 nucleus|cytoplasm|methyltransferase activity METTL9 1587.81513101426 1419.23995535651 1756.39030667201 1.23755697550863 0.30749494651877 0.0329848490575949 0.717059810541268 15.8741 17.1165 22.2645 18.923 GeneID:51108,Genbank:NM_001288659.1,HGNC:HGNC:24586,MIM:609388 methyltransferase like 9 MEX3A 247.79746129575 230.031524613324 265.563397978177 1.1544652343829 0.207224728383943 0.335704296378347 1 1.39649 1.48976 1.69517 1.76563 GeneID:92312,Genbank:NM_001093725.1,HGNC:HGNC:33482,MIM:611007 mex-3 RNA binding family member A GO:0000932,GO:0003723,GO:0005634,GO:0005829,GO:0046872 P-body|RNA binding|nucleus|cytosol|metal ion binding MEX3B 186.672297862832 185.800636923322 187.543958802342 1.00938275512876 0.0134733441338223 0.949644904667709 1 3.2113 2.75786 2.97058 3.12954 GeneID:84206,Genbank:NM_032246.4,HGNC:HGNC:25297,MIM:611008 mex-3 RNA binding family member B GO:0000932,GO:0003723,GO:0005509,GO:0005654,GO:0005829,GO:0006468,GO:0046777 P-body|RNA binding|calcium ion binding|nucleoplasm|cytosol|protein phosphorylation|protein autophosphorylation MEX3C 575.675948795017 619.717414057705 531.63448353233 0.857865974834179 -0.221175823089698 0.191283959659951 1 7.43016 7.59951 6.57545 6.36405 GeneID:51320,Genbank:NM_016626.4,HGNC:HGNC:28040,MIM:611005 mex-3 RNA binding family member C GO:0003415,GO:0003723,GO:0005634,GO:0005737,GO:0016740,GO:0045598,GO:0046872,GO:0097009 chondrocyte hypertrophy|RNA binding|nucleus|cytoplasm|transferase activity|regulation of fat cell differentiation|metal ion binding|energy homeostasis MEX3D 1363.53879979788 1078.86796406534 1648.20963553043 1.52772136204668 0.611381437188939 3.29122483443218e-05 0.011205693979571 20.3488 19.6518 32.0796 30.4309 GeneID:399664,Genbank:NM_001174118.1,HGNC:HGNC:16734,MIM:611009 mex-3 RNA binding family member D GO:0003723,GO:0005634,GO:0010609,GO:0017091,GO:0046872,GO:0048471,GO:0061157 RNA binding|nucleus|mRNA localization resulting in posttranscriptional regulation of gene expression|AU-rich element binding|metal ion binding|perinuclear region of cytoplasm|mRNA destabilization MFAP1 987.794056295179 1010.17070689619 965.417405694168 0.955697288689423 -0.0653743692163897 0.697715409920509 1 14.1553 12.7559 14.02 11.9182 GeneID:4236,Genbank:NM_005926.2,HGNC:HGNC:7032,MIM:600215 microfibril associated protein 1 GO:0001527,GO:0003723,GO:0005576,GO:0005634 microfibril|RNA binding|extracellular region|nucleus MFAP2 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0424283 0 0 GeneID:4237,Genbank:NM_001135247.1,HGNC:HGNC:7033,MIM:156790 microfibril associated protein 2 GO:0001527,GO:0005576,GO:0005578,GO:0030198,GO:0048048,GO:0048050 microfibril|extracellular region|proteinaceous extracellular matrix|extracellular matrix organization|embryonic eye morphogenesis|post-embryonic eye morphogenesis MFAP3 683.156682375283 701.825844520769 664.487520229797 0.94679830533105 -0.0788709710842453 0.684907942545245 1 6.3454 5.66046 6.44651 4.98507 GeneID:4238,Genbank:NM_001242336.1,HGNC:HGNC:7034,MIM:600491 microfibril associated protein 3 GO:0005576,GO:0005886,GO:0016021 extracellular region|plasma membrane|integral component of membrane MFAP3L 418.605365378703 399.02565504604 438.185075711365 1.098137601355 0.135058841551172 0.654110832679849 1 1.52388 1.3762 1.97835 1.25846 GeneID:9848,Genbank:NM_001301647.1,HGNC:HGNC:29083,MIM:616523 microfibril associated protein 3 like GO:0005634,GO:0005737,GO:0005886,GO:0016021 nucleus|cytoplasm|plasma membrane|integral component of membrane MFAP4 2.50814872928195 2.59443583384164 2.42186162472226 0.933482953454339 -0.0993044175793639 1 1 0 0 0.0221648 0.0415661 GeneID:4239,Genbank:NM_002404.2,HGNC:HGNC:7035,MIM:600596 microfibril associated protein 4 GO:0001527,GO:0005576,GO:0005578,GO:0007155,GO:0009650,GO:0010712,GO:0031012,GO:0048251,GO:0070062,GO:0071493,GO:0071953,GO:0097435 microfibril|extracellular region|proteinaceous extracellular matrix|cell adhesion|UV protection|regulation of collagen metabolic process|extracellular matrix|elastic fiber assembly|extracellular exosome|cellular response to UV-B|elastic fiber|supramolecular fiber organization MFAP5 2.51152025102044 3.084507235799 1.93853326624189 0.628474215830372 -0.670074537921313 0.833675698800589 1 0.0460872 0.0295696 0.0147794 0.0275757 GeneID:8076,Genbank:NM_001297710.1,HGNC:HGNC:29673,MIM:601103 microfibril associated protein 5 GO:0001527,GO:0005201,GO:0005576,GO:0005578,GO:0005615,GO:0030198,GO:0031012,GO:0060216,GO:0097435 microfibril|extracellular matrix structural constituent|extracellular region|proteinaceous extracellular matrix|extracellular space|extracellular matrix organization|extracellular matrix|definitive hemopoiesis|supramolecular fiber organization MFF 1429.59878179424 1419.41244314504 1439.78512044345 1.0143528946761 0.0205596551294716 0.886657158485503 1 16.8948 17.2033 16.2422 16.818 GeneID:56947,Genbank:NM_001277061.1,HGNC:HGNC:24858,MIM:614785 mitochondrial fission factor GO:0000266,GO:0001836,GO:0005739,GO:0005741,GO:0005777,GO:0006626,GO:0008021,GO:0008053,GO:0010821,GO:0016559,GO:0030054,GO:0032592,GO:0042803,GO:0043653,GO:0051260,GO:0070584,GO:0090141,GO:0090200,GO:0090314,GO:1900063 mitochondrial fission|release of cytochrome c from mitochondria|mitochondrion|mitochondrial outer membrane|peroxisome|protein targeting to mitochondrion|synaptic vesicle|mitochondrial fusion|regulation of mitochondrion organization|peroxisome fission|cell junction|integral component of mitochondrial membrane|protein homodimerization activity|mitochondrial fragmentation involved in apoptotic process|protein homooligomerization|mitochondrion morphogenesis|positive regulation of mitochondrial fission|positive regulation of release of cytochrome c from mitochondria|positive regulation of protein targeting to membrane|regulation of peroxisome organization MFGE8 2217.002726932 2118.52142431983 2315.48402954417 1.09297173158755 0.128256087902907 0.365775055185833 1 12.1368 13.2172 14.6701 14.5873 GeneID:4240,Genbank:NM_001310319.1,HGNC:HGNC:7036,MIM:602281 milk fat globule-EGF factor 8 protein GO:0001525,GO:0001786,GO:0005178,GO:0005576,GO:0005615,GO:0005788,GO:0006910,GO:0006911,GO:0007155,GO:0007338,GO:0008429,GO:0009897,GO:0016020,GO:0016032,GO:0019897,GO:0031012,GO:0043277,GO:0043687,GO:0044267,GO:0050766,GO:0070062,GO:1903561 angiogenesis|phosphatidylserine binding|integrin binding|extracellular region|extracellular space|endoplasmic reticulum lumen|phagocytosis, recognition|phagocytosis, engulfment|cell adhesion|single fertilization|phosphatidylethanolamine binding|external side of plasma membrane|membrane|viral process|extrinsic component of plasma membrane|extracellular matrix|apoptotic cell clearance|post-translational protein modification|cellular protein metabolic process|positive regulation of phagocytosis|extracellular exosome|extracellular vesicle MFHAS1 1638.80770294988 1698.16193330513 1579.45347259463 0.930095912302393 -0.104548599023418 0.467424735208624 1 11.6584 11.569 11.5549 10.3303 GeneID:9258,Genbank:XM_024447330.1,HGNC:HGNC:16982,MIM:605352 malignant fibrous histiocytoma amplified sequence 1 GO:0007165 signal transduction MFN1 648.228694501197 611.183269469728 685.274119532667 1.1212252588773 0.165076150773216 0.294737609765108 1 6.8755 5.63525 7.29981 6.7524 GeneID:55669,Genbank:NM_033540.2,HGNC:HGNC:18262,MIM:608506 mitofusin 1 GO:0003924,GO:0005525,GO:0005739,GO:0005741,GO:0008053,GO:0016021,GO:0016236,GO:0031307,GO:0046039,GO:0051646,GO:0098799,GO:1990613 GTPase activity|GTP binding|mitochondrion|mitochondrial outer membrane|mitochondrial fusion|integral component of membrane|macroautophagy|integral component of mitochondrial outer membrane|GTP metabolic process|mitochondrion localization|outer mitochondrial membrane protein complex|mitochondrial membrane fusion hsa04137,hsa04621 Mitophagy - animal|NOD-like receptor signaling pathway MFN2 5785.07229997049 5633.12498659035 5937.01961335064 1.05394778697148 0.0758033970100766 0.575508192636241 1 40.945 42.051 43.8795 44.4615 GeneID:9927,Genbank:NM_014874.3,HGNC:HGNC:16877,MIM:608507 mitofusin 2 hsa04137,hsa04621 Mitophagy - animal|NOD-like receptor signaling pathway MFNG 1.29471636723572 2.10436443188427 0.48506830258717 0.230505845488385 -2.11712475789794 0.629247717445654 1 0.0774163 0.0224675 0.0239532 0 GeneID:4242,Genbank:NM_002405.3,HGNC:HGNC:7038,MIM:602577 MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase hsa00514,hsa04330,hsa05165 Other types of O-glycan biosynthesis|Notch signaling pathway|Human papillomavirus infection MFSD1 795.342827243624 763.901216435083 826.784438052164 1.0823185253069 0.114125145425067 0.468872548503395 1 15.6895 16.4403 18.1737 16.5533 GeneID:64747,Genbank:NM_022736.2,HGNC:HGNC:25874 major facilitator superfamily domain containing 1 GO:0016021,GO:0055085 integral component of membrane|transmembrane transport MFSD10 1301.15479679468 1363.14352681677 1239.16606677259 0.90905032551217 -0.13756792988812 0.336096338809303 1 28.0697 27.8354 24.9766 25.6666 GeneID:10227,Genbank:XM_024453871.1,HGNC:HGNC:16894,MIM:610977 major facilitator superfamily domain containing 10 GO:0006810,GO:0006915,GO:0008493,GO:0008514,GO:0016021,GO:0030659,GO:0031526,GO:0043252 transport|apoptotic process|tetracycline transmembrane transporter activity|organic anion transmembrane transporter activity|integral component of membrane|cytoplasmic vesicle membrane|brush border membrane|sodium-independent organic anion transport MFSD11 702.952704529132 645.027622170109 760.877786888154 1.17960496688232 0.238303802182859 0.141221546273661 1 4.74389 4.83211 5.55326 5.47582 GeneID:79157,Genbank:NM_001242534.2,HGNC:HGNC:25458 major facilitator superfamily domain containing 11 GO:0016021 integral component of membrane MFSD12 2209.76517559669 2152.38437732958 2267.14597386381 1.05331835602552 0.0749415439078113 0.607763812265067 1 26.4356 27.0648 31.0765 28.034 GeneID:126321,Genbank:XM_006722647.3,HGNC:HGNC:28299,MIM:617745 major facilitator superfamily domain containing 12 GO:0005765,GO:0016021 lysosomal membrane|integral component of membrane MFSD13A 386.24805716965 436.693509411856 335.802604927443 0.768966329221851 -0.379007666697865 0.0610501226779117 0.882851581387291 3.34212 3.1007 2.2303 2.85718 GeneID:79847,Genbank:XM_017016656.1,HGNC:HGNC:26196 major facilitator superfamily domain containing 13A GO:0016021 integral component of membrane MFSD14A 1140.52833409307 1138.692858722 1142.36380946413 1.00322382872081 0.0046435207656137 0.969058682816794 1 15.9194 16.3602 17.9466 14.5749 GeneID:64645,Genbank:XM_011541957.1,HGNC:HGNC:23363 major facilitator superfamily domain containing 14A GO:0005215,GO:0016021,GO:0055085 transporter activity|integral component of membrane|transmembrane transport MFSD14B 1932.42515897547 1964.52435124649 1900.32596670444 0.967321156135674 -0.0479331426809917 0.744948463159911 1 28.4061 27.1738 29.2638 24.8343 GeneID:84641,Genbank:XM_011519114.2,HGNC:HGNC:23376 major facilitator superfamily domain containing 14B GO:0005215,GO:0016021,GO:0055085 transporter activity|integral component of membrane|transmembrane transport MFSD14C 200.998681512631 188.750873990174 213.246489035088 1.12977749202999 0.176038664008478 0.444698411423962 1 2.23356 2.1418 2.73118 2.40407 GeneID:84278,Genbank:XM_024447698.1,HGNC:HGNC:23672 major facilitator superfamily domain containing 14C GO:0005215,GO:0016021,GO:0055085 transporter activity|integral component of membrane|transmembrane transport MFSD2A 999.076216348285 1056.58341125809 941.569021438484 0.891144997551445 -0.166267904184907 0.28287639125937 1 21.6203 19.778 17.7268 19.7485 GeneID:84879,Genbank:NM_001136493.2,HGNC:HGNC:25897,MIM:614397 major facilitator superfamily domain containing 2A GO:0005548,GO:0005789,GO:0005886,GO:0005887,GO:0006656,GO:0015245,GO:0015293,GO:0015908,GO:0021766,GO:0045056,GO:0051977,GO:0051978,GO:0060856,GO:1990379 phospholipid transporter activity|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|phosphatidylcholine biosynthetic process|fatty acid transmembrane transporter activity|symporter activity|fatty acid transport|hippocampus development|transcytosis|lysophospholipid transport|lysophospholipid transporter activity|establishment of blood-brain barrier|lipid transport across blood brain barrier MFSD2B 41.2117185831536 46.0755034382452 36.3479337280621 0.788877625108948 -0.342126575816438 0.447495985634122 1 0.457155 0.479385 0.394166 0.35861 GeneID:388931,Genbank:XM_017004063.2,HGNC:HGNC:37207,MIM:617845 major facilitator superfamily domain containing 2B GO:0005887,GO:0006869,GO:0046624 integral component of plasma membrane|lipid transport|sphingolipid transporter activity MFSD3 625.836363042117 580.542144867295 671.13058121694 1.156041102529 0.209192693133215 0.411156862760488 1 13.2997 13.7716 13.6871 17.1887 GeneID:113655,Genbank:XM_017013005.1,HGNC:HGNC:25157 major facilitator superfamily domain containing 3 GO:0005887,GO:0015295 integral component of plasma membrane|solute:proton symporter activity MFSD4A 4.21045590168054 3.57457863775636 4.84633316560471 1.35577746546558 0.439120396899037 0.847047916343533 1 0.04204 0.0514575 0.0531298 0.0494142 GeneID:148808,Genbank:NM_181644.4,HGNC:HGNC:25433 major facilitator superfamily domain containing 4A GO:0005355,GO:0016021 glucose transmembrane transporter activity|integral component of membrane MFSD4B 175.333938676432 179.10333343019 171.564543922674 0.957908156352354 -0.0620407570124586 0.808159044082689 1 2.02823 2.05641 2.05343 1.82537 GeneID:91749,Genbank:NM_153369.2,HGNC:HGNC:21053,MIM:617331 major facilitator superfamily domain containing 4B GO:0005355,GO:0006814,GO:0015293,GO:0016021,GO:0016324 glucose transmembrane transporter activity|sodium ion transport|symporter activity|integral component of membrane|apical plasma membrane MFSD5 739.688851537791 762.643741639021 716.733961436561 0.939801800374321 -0.0895715633809181 0.557777167403357 1 13.0073 14.9485 12.9221 13.3955 GeneID:84975,Genbank:XM_005269197.1,HGNC:HGNC:28156 major facilitator superfamily domain containing 5 GO:0005886,GO:0015098,GO:0016020,GO:0016021 plasma membrane|molybdate ion transmembrane transporter activity|membrane|integral component of membrane MFSD6 933.225393539666 863.171954621762 1003.27883245757 1.16231629988164 0.217002721217077 0.185431533813784 1 5.98142 5.6976 7.88975 6.13682 GeneID:54842,Genbank:NM_017694.3,HGNC:HGNC:24711,MIM:613476 major facilitator superfamily domain containing 6 GO:0016020,GO:0016021 membrane|integral component of membrane MFSD8 179.925915276933 179.55518721257 180.296643341296 1.00412940522764 0.00594520579253812 1 1 1.20759 1.41183 1.5397 1.14872 GeneID:256471,Genbank:XM_024453981.1,HGNC:HGNC:28486,MIM:611124 major facilitator superfamily domain containing 8 hsa04142 Lysosome MFSD9 241.804988427214 271.340584200942 212.269392653486 0.782298723497587 -0.354208484010769 0.100527936612443 1 2.13888 1.95155 1.68104 1.53272 GeneID:84804,Genbank:NM_032718.4,HGNC:HGNC:28158 major facilitator superfamily domain containing 9 GO:0005215,GO:0016021,GO:0055085 transporter activity|integral component of membrane|transmembrane transport MGA 375.495672977035 390.848328691928 360.143017262141 0.921439317567125 -0.118038936223608 0.680592633897507 1 1.03072 0.955195 1.13603 0.723064 GeneID:23269,Genbank:XM_006720445.4,HGNC:HGNC:14010,MIM:616061 MGA, MAX dimerization protein GO:0003677,GO:0003700,GO:0005654,GO:0006351,GO:0046983,GO:0070317,GO:0071339 DNA binding|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|protein dimerization activity|negative regulation of G0 to G1 transition|MLL1 complex MGAM 7.58052046408787 8.85950285480952 6.30153807336622 0.711274455986584 -0.491521741951107 0.706643970966479 1 0.034079 0.0139986 0.0216345 0.0167763 GeneID:8972,Genbank:XM_017012772.1,HGNC:HGNC:7043,MIM:154360 maltase-glucoamylase GO:0003824,GO:0004339,GO:0004558,GO:0005886,GO:0005983,GO:0016021,GO:0016160,GO:0016324,GO:0030246,GO:0032450,GO:0043312,GO:0044245,GO:0070062,GO:0070821,GO:0101003 catalytic activity|glucan 1,4-alpha-glucosidase activity|alpha-1,4-glucosidase activity|plasma membrane|starch catabolic process|integral component of membrane|amylase activity|apical plasma membrane|carbohydrate binding|maltose alpha-glucosidase activity|neutrophil degranulation|polysaccharide digestion|extracellular exosome|tertiary granule membrane|ficolin-1-rich granule membrane hsa00052,hsa00500,hsa04973 Galactose metabolism|Starch and sucrose metabolism|Carbohydrate digestion and absorption MGAM2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:93432,Genbank:XM_024446997.1,HGNC:HGNC:28101 maltase-glucoamylase 2 (putative) GO:0004339,GO:0005975,GO:0016021,GO:0030246 glucan 1,4-alpha-glucosidase activity|carbohydrate metabolic process|integral component of membrane|carbohydrate binding hsa00052,hsa00500,hsa04973 Galactose metabolism|Starch and sucrose metabolism|Carbohydrate digestion and absorption MGARP 2.02688693445997 3.084507235799 0.969266633120943 0.314237107915186 -1.67007453792131 0.551886710190974 1 0.102972 0.0965035 0.0327079 0 GeneID:84709,Genbank:NM_032623.3,HGNC:HGNC:29969 mitochondria localized glutamic acid rich protein GO:0005739,GO:0006626,GO:0008089,GO:0008090,GO:0010821,GO:0010822,GO:0019896,GO:0031307,GO:0071383,GO:0071456,GO:0097211,GO:1904115 mitochondrion|protein targeting to mitochondrion|anterograde axonal transport|retrograde axonal transport|regulation of mitochondrion organization|positive regulation of mitochondrion organization|axonal transport of mitochondrion|integral component of mitochondrial outer membrane|cellular response to steroid hormone stimulus|cellular response to hypoxia|cellular response to gonadotropin-releasing hormone|axon cytoplasm MGAT1 2998.90421992307 2921.76465708216 3076.04378276398 1.05280340608812 0.0742360616805571 0.609655397680858 1 26.9884 30.2055 32.7976 28.5145 GeneID:4245,Genbank:XM_011534563.2,HGNC:HGNC:7044,MIM:160995 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase hsa00510 N-Glycan biosynthesis MGAT2 1162.16141984202 1239.68476814394 1084.6380715401 0.874930546387223 -0.192759597210586 0.196672920859752 1 21.7118 22.3867 20.9857 18.2982 GeneID:4247,Genbank:NM_002408.3,HGNC:HGNC:7045,MIM:602616 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase hsa00510 N-Glycan biosynthesis MGAT3 2.01894729937798 1.61429302992691 2.42360156882906 1.50133930079521 0.586250061073463 0.889673586941906 1 0.00794402 0 0.00743796 0.00463507 GeneID:4248,Genbank:XM_005261608.5,HGNC:HGNC:7046,MIM:604621 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase hsa00510 N-Glycan biosynthesis MGAT4A 41.8159955065946 51.1585139014507 32.4734771117385 0.634761931792895 -0.655712486028131 0.145361364423447 1 0.273938 0.222384 0.173163 0.115807 GeneID:11320,Genbank:NM_012214.2,HGNC:HGNC:7047,MIM:604623 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A GO:0000139,GO:0005788,GO:0005975,GO:0006487,GO:0006491,GO:0008454,GO:0016021,GO:0043687,GO:0044267,GO:0046872,GO:0070062 Golgi membrane|endoplasmic reticulum lumen|carbohydrate metabolic process|protein N-linked glycosylation|N-glycan processing|alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|integral component of membrane|post-translational protein modification|cellular protein metabolic process|metal ion binding|extracellular exosome hsa00510 N-Glycan biosynthesis MGAT4B 8645.11555970715 8008.40459091541 9281.8265284989 1.15901068972315 0.212893872590679 0.109084711802104 1 68.1447 70.1878 82.2046 82.1906 GeneID:11282,Genbank:NM_014275.4,HGNC:HGNC:7048,MIM:604561 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B GO:0000139,GO:0005975,GO:0006487,GO:0006491,GO:0008454,GO:0016021,GO:0046872 Golgi membrane|carbohydrate metabolic process|protein N-linked glycosylation|N-glycan processing|alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|integral component of membrane|metal ion binding hsa00510 N-Glycan biosynthesis MGAT4C 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.00729713 0 0 0 GeneID:25834,Genbank:XM_024448930.1,HGNC:HGNC:30871,MIM:607385 MGAT4 family member C GO:0000139,GO:0005975,GO:0006486,GO:0008454,GO:0016021,GO:0046872 Golgi membrane|carbohydrate metabolic process|protein glycosylation|alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|integral component of membrane|metal ion binding hsa00510 N-Glycan biosynthesis MGAT5 1292.61061826683 1294.11110272568 1291.11013380798 0.997681057745831 -0.00334941153886516 0.974387725596157 1 5.0998 5.39363 5.62027 4.89667 GeneID:4249,Genbank:XM_017004149.1,HGNC:HGNC:7049,MIM:601774 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase hsa00510 N-Glycan biosynthesis MGAT5B 736.92728738504 693.612334548789 780.242240221291 1.12489672019581 0.169792549796779 0.310205850630817 1 2.8251 3.04503 3.29939 3.42006 GeneID:146664,Genbank:XM_011524354.3,HGNC:HGNC:24140,MIM:612441 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B GO:0000139,GO:0005794,GO:0006487,GO:0016021,GO:0030144,GO:0046872 Golgi membrane|Golgi apparatus|protein N-linked glycosylation|integral component of membrane|alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding hsa00510,hsa00515 N-Glycan biosynthesis|Mannose type O-glycan biosynthesis MGEA5 2763.54340685876 2666.48344893535 2860.60336478216 1.07279997028458 0.101381102393901 0.593909018790426 1 16.2071 14.604 19.1898 14.1632 GeneID:10724,Genbank:NM_001142434.1,HGNC:HGNC:7056,MIM:604039 meningioma expressed antigen 5 (hyaluronidase) GO:0004415,GO:0005634,GO:0005829,GO:0006044,GO:0006493,GO:0006516,GO:0006517,GO:0016020,GO:0016231,GO:0102166,GO:0102167,GO:0102571 hyalurononglucosaminidase activity|nucleus|cytosol|N-acetylglucosamine metabolic process|protein O-linked glycosylation|glycoprotein catabolic process|protein deglycosylation|membrane|beta-N-acetylglucosaminidase activity|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity|[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity hsa04931 Insulin resistance MGLL 149.17140844447 131.135187969016 167.207628919923 1.27507827235075 0.350585811528231 0.178205819778747 1 0.65151 0.824777 1.09343 0.826681 GeneID:11343,Genbank:NM_001003794.2,HGNC:HGNC:17038,MIM:609699 monoglyceride lipase GO:0004622,GO:0005654,GO:0005789,GO:0005829,GO:0005886,GO:0006629,GO:0006633,GO:0006954,GO:0009966,GO:0016020,GO:0019369,GO:0019433,GO:0019898,GO:0036155,GO:0042803,GO:0046464,GO:0047372,GO:0050727,GO:0051930,GO:2000124 lysophospholipase activity|nucleoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|lipid metabolic process|fatty acid biosynthetic process|inflammatory response|regulation of signal transduction|membrane|arachidonic acid metabolic process|triglyceride catabolic process|extrinsic component of membrane|acylglycerol acyl-chain remodeling|protein homodimerization activity|acylglycerol catabolic process|acylglycerol lipase activity|regulation of inflammatory response|regulation of sensory perception of pain|regulation of endocannabinoid signaling pathway hsa00561,hsa04714,hsa04723,hsa04923 Glycerolipid metabolism|Thermogenesis|Retrograde endocannabinoid signaling|Regulation of lipolysis in adipocytes MGME1 707.535246780553 739.974978634289 675.095514926817 0.912322084420726 -0.132384854308916 0.413733428975639 1 7.51592 7.75492 7.27594 6.52698 GeneID:92667,Genbank:XM_017028128.1,HGNC:HGNC:16205,MIM:615076 mitochondrial genome maintenance exonuclease 1 GO:0000002,GO:0003677,GO:0005739,GO:0006264,GO:0008297,GO:0043504 mitochondrial genome maintenance|DNA binding|mitochondrion|mitochondrial DNA replication|single-stranded DNA exodeoxyribonuclease activity|mitochondrial DNA repair MGP 509.681987356176 385.573213129983 633.790761582369 1.64376242954592 0.717001803592143 0.0394869041756172 0.756156754175857 5.03432 5.28428 7.18251 10.3935 GeneID:4256,Genbank:NM_000900.4,HGNC:HGNC:7060,MIM:154870 matrix Gla protein GO:0001503,GO:0005201,GO:0005509,GO:0030154,GO:0030500,GO:0031012,GO:0051216 ossification|extracellular matrix structural constituent|calcium ion binding|cell differentiation|regulation of bone mineralization|extracellular matrix|cartilage development MGRN1 666.612525798714 649.400047168149 683.825004429279 1.053010401541 0.0745196872444548 0.657988395414176 1 3.82333 3.91276 4.51693 3.80163 GeneID:23295,Genbank:XM_011522441.1,HGNC:HGNC:20254,MIM:607559 mahogunin ring finger 1 GO:0000209,GO:0004842,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0006513,GO:0008333,GO:0016020,GO:0043951,GO:0045744,GO:0046872,GO:0061630,GO:0070062 protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|cytoplasm|early endosome|cytosol|plasma membrane|protein monoubiquitination|endosome to lysosome transport|membrane|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|metal ion binding|ubiquitin protein ligase activity|extracellular exosome hsa04120 Ubiquitin mediated proteolysis MGST1 3863.19253797594 4108.31369805573 3618.07137789615 0.880670670209143 -0.183325475607558 0.180702583932509 1 26.504 25.6259 22.2168 22.8321 GeneID:4257,Genbank:NM_145792.2,HGNC:HGNC:7061,MIM:138330 microsomal glutathione S-transferase 1 hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis MGST2 616.059449718443 645.757824945491 586.361074491394 0.908020084063075 -0.13920388673488 0.408845275735357 1 5.30115 5.3055 4.59589 4.94159 GeneID:4258,Genbank:XM_017008211.2,HGNC:HGNC:7063,MIM:601733 microsomal glutathione S-transferase 2 hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis MGST3 1816.74376575969 1735.88965660245 1897.59787491692 1.09315581649987 0.128499054870653 0.584542622806776 1 37.9264 43.7144 41.8071 49.9237 GeneID:4259,Genbank:NM_004528.3,HGNC:HGNC:7064,MIM:604564 microsomal glutathione S-transferase 3 hsa00480,hsa00980,hsa00982,hsa00983,hsa01524,hsa05200,hsa05204,hsa05225,hsa05418 Glutathione metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Platinum drug resistance|Pathways in cancer|Chemical carcinogenesis|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis MIA 1.49422734321456 2.98845468642911 0 0 -Inf 0.224695876647012 1 0 0.250386 0 0 GeneID:8190,Genbank:NM_001202553.1,HGNC:HGNC:7076,MIM:601340 melanoma inhibitory activity GO:0005615,GO:0008083,GO:0008283 extracellular space|growth factor activity|cell proliferation MIA2 214.100654260984 229.473809626465 198.727498895502 0.866013856740289 -0.207537985766122 0.39160420837926 1 0.808296 0.760929 0.747908 0.567973 GeneID:4253,Genbank:XM_024449592.1,HGNC:HGNC:18432,MIM:602132 melanoma inhibitory activity 2 GO:0005789,GO:0006888,GO:0008047,GO:0016020,GO:0016021,GO:0032527,GO:0035459,GO:0070971,GO:0070973 endoplasmic reticulum membrane|ER to Golgi vesicle-mediated transport|enzyme activator activity|membrane|integral component of membrane|protein exit from endoplasmic reticulum|cargo loading into vesicle|endoplasmic reticulum exit site|protein localization to endoplasmic reticulum exit site MIA3 468.376224358651 475.311063615409 461.441385101894 0.970819786082789 -0.0427245828212367 0.925856354141586 1 1.59781 1.17963 1.64559 1.06413 GeneID:375056,Genbank:NM_001324064.1,HGNC:HGNC:24008,MIM:613455 MIA family member 3, ER export factor GO:0000139,GO:0002687,GO:0005788,GO:0005789,GO:0006887,GO:0006888,GO:0007162,GO:0015031,GO:0016020,GO:0016021,GO:0030336,GO:0042060,GO:0042953,GO:0042954,GO:0043231,GO:0043687,GO:0044267,GO:0070971,GO:0090110 Golgi membrane|positive regulation of leukocyte migration|endoplasmic reticulum lumen|endoplasmic reticulum membrane|exocytosis|ER to Golgi vesicle-mediated transport|negative regulation of cell adhesion|protein transport|membrane|integral component of membrane|negative regulation of cell migration|wound healing|lipoprotein transport|lipoprotein transporter activity|intracellular membrane-bounded organelle|post-translational protein modification|cellular protein metabolic process|endoplasmic reticulum exit site|cargo loading into COPII-coated vesicle MIB1 453.749298931371 486.746401994699 420.752195868043 0.864417680631618 -0.210199513783547 0.563263605531919 1 1.40149 1.28492 1.49359 0.844438 GeneID:57534,Genbank:XM_017025874.1,HGNC:HGNC:21086,MIM:608677 mindbomb E3 ubiquitin protein ligase 1 GO:0001568,GO:0001701,GO:0001756,GO:0001841,GO:0001947,GO:0004842,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0006897,GO:0007219,GO:0008270,GO:0014069,GO:0031410,GO:0045665,GO:0045807 blood vessel development|in utero embryonic development|somitogenesis|neural tube formation|heart looping|ubiquitin-protein transferase activity|cytoplasm|centrosome|cytosol|plasma membrane|endocytosis|Notch signaling pathway|zinc ion binding|postsynaptic density|cytoplasmic vesicle|negative regulation of neuron differentiation|positive regulation of endocytosis MIB2 579.917161787975 549.697072509305 610.137251066646 1.10995179268727 0.150497018952587 0.393460622011563 1 2.11073 2.31009 2.51548 2.49813 GeneID:142678,Genbank:XM_017000357.2,HGNC:HGNC:30577,MIM:611141 mindbomb E3 ubiquitin protein ligase 2 MICA 2228.51935266718 2320.88640235863 2136.15230297572 0.920403644402774 -0.119661398861866 0.39557284195688 1 38.6542 36.3423 34.0119 35.3682 GeneID:100507436,Genbank:NM_001289152.1,HGNC:HGNC:7090,IMGT/GENE-DB:MICA,MIM:600169 MHC class I polypeptide-related sequence A GO:0001913,GO:0002418,GO:0005615,GO:0005737,GO:0005886,GO:0005887,GO:0006974,GO:0009408,GO:0009986,GO:0016032,GO:0019835,GO:0032815,GO:0042267,GO:0042742,GO:0045953,GO:0046629,GO:0046703,GO:0050776,GO:0051607 T cell mediated cytotoxicity|immune response to tumor cell|extracellular space|cytoplasm|plasma membrane|integral component of plasma membrane|cellular response to DNA damage stimulus|response to heat|cell surface|viral process|cytolysis|negative regulation of natural killer cell activation|natural killer cell mediated cytotoxicity|defense response to bacterium|negative regulation of natural killer cell mediated cytotoxicity|gamma-delta T cell activation|natural killer cell lectin-like receptor binding|regulation of immune response|defense response to virus hsa04650,hsa05167 Natural killer cell mediated cytotoxicity|Kaposi sarcoma-associated herpesvirus infection MICAL1 954.344456338211 847.827887683631 1060.86102499279 1.2512693205825 0.323392345579439 0.0376936399068558 0.744558420459959 7.06249 7.42758 9.62607 9.09012 GeneID:64780,Genbank:NM_001286613.1,HGNC:HGNC:20619,MIM:607129 microtubule associated monooxygenase, calponin and LIM domain containing 1 GO:0001933,GO:0003779,GO:0004497,GO:0005737,GO:0005829,GO:0005882,GO:0007010,GO:0007165,GO:0007596,GO:0016709,GO:0017124,GO:0017137,GO:0019417,GO:0019901,GO:0030042,GO:0030496,GO:0043154,GO:0046872,GO:0055114,GO:0071949,GO:1903305,GO:1990026 negative regulation of protein phosphorylation|actin binding|monooxygenase activity|cytoplasm|cytosol|intermediate filament|cytoskeleton organization|signal transduction|blood coagulation|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|SH3 domain binding|Rab GTPase binding|sulfur oxidation|protein kinase binding|actin filament depolymerization|midbody|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|metal ion binding|oxidation-reduction process|FAD binding|regulation of regulated secretory pathway|hippocampal mossy fiber expansion MICAL2 890.659869089747 838.621375250064 942.69836292943 1.12410485917835 0.168776619865344 0.287875443643118 1 3.70358 3.75142 4.97688 3.78332 GeneID:9645,Genbank:NM_001346293.1,HGNC:HGNC:24693,MIM:608881 microtubule associated monooxygenase, calponin and LIM domain containing 2 GO:0001947,GO:0003779,GO:0005634,GO:0007010,GO:0007507,GO:0010735,GO:0016491,GO:0016709,GO:0019417,GO:0030042,GO:0043914,GO:0046872,GO:0055114,GO:0071949 heart looping|actin binding|nucleus|cytoskeleton organization|heart development|positive regulation of transcription via serum response element binding|oxidoreductase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|sulfur oxidation|actin filament depolymerization|NADPH:sulfur oxidoreductase activity|metal ion binding|oxidation-reduction process|FAD binding MICAL3 2966.70601536943 2659.96371823502 3273.44831250384 1.23063645194224 0.299404631486635 0.0294609714423775 0.679894695419479 3.85327 4.11085 5.63207 4.33811 GeneID:57553,Genbank:NM_015241.2,HGNC:HGNC:24694,MIM:608882 microtubule associated monooxygenase, calponin and LIM domain containing 3 GO:0003779,GO:0005634,GO:0005654,GO:0005819,GO:0005829,GO:0005886,GO:0005938,GO:0006887,GO:0007010,GO:0007049,GO:0016709,GO:0030042,GO:0030496,GO:0042995,GO:0046872,GO:0051301,GO:0055114,GO:0071949 actin binding|nucleus|nucleoplasm|spindle|cytosol|plasma membrane|cell cortex|exocytosis|cytoskeleton organization|cell cycle|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|actin filament depolymerization|midbody|cell projection|metal ion binding|cell division|oxidation-reduction process|FAD binding MICALCL 6.168760811473 3.13253351048394 9.20498811246207 2.9385122558641 1.55508591549102 0.209037963458547 1 0.0264455 0.0125103 0.0378549 0.064776 GeneID:84953,Genbank:NM_032867.3,HGNC:HGNC:25933,MIM:612355 MICAL C-terminal like GO:0005737,GO:0007275,GO:0007283,GO:0030154,GO:0051019 cytoplasm|multicellular organism development|spermatogenesis|cell differentiation|mitogen-activated protein kinase binding MICALL1 2995.53069810595 3117.32850442506 2873.73289178684 0.92185757378716 -0.117384222175478 0.372449618821495 1 19.7616 22.0168 19.2244 20.1123 GeneID:85377,Genbank:NM_033386.3,HGNC:HGNC:29804 MICAL like 1 GO:0005770,GO:0006612,GO:0006897,GO:0006898,GO:0017137,GO:0019898,GO:0031175,GO:0031902,GO:0032458,GO:0036010,GO:0042802,GO:0045296,GO:0046872,GO:0055038,GO:0070300,GO:0097320,GO:1990090,GO:1990126 late endosome|protein targeting to membrane|endocytosis|receptor-mediated endocytosis|Rab GTPase binding|extrinsic component of membrane|neuron projection development|late endosome membrane|slow endocytic recycling|protein localization to endosome|identical protein binding|cadherin binding|metal ion binding|recycling endosome membrane|phosphatidic acid binding|plasma membrane tubulation|cellular response to nerve growth factor stimulus|retrograde transport, endosome to plasma membrane MICALL2 428.845191214762 430.75583465943 426.934547770093 0.991128879560371 -0.0128554271695299 0.925511176776427 1 2.13558 2.40119 2.23871 2.57701 GeneID:79778,Genbank:XM_011515524.2,HGNC:HGNC:29672 MICAL like 2 GO:0001725,GO:0005829,GO:0005886,GO:0005911,GO:0005923,GO:0017137,GO:0030041,GO:0031005,GO:0031175,GO:0031532,GO:0032456,GO:0034446,GO:0042805,GO:0043005,GO:0046872,GO:0051015,GO:0055037,GO:0070830,GO:1903955 stress fiber|cytosol|plasma membrane|cell-cell junction|bicellular tight junction|Rab GTPase binding|actin filament polymerization|filamin binding|neuron projection development|actin cytoskeleton reorganization|endocytic recycling|substrate adhesion-dependent cell spreading|actinin binding|neuron projection|metal ion binding|actin filament binding|recycling endosome|bicellular tight junction assembly|positive regulation of protein targeting to mitochondrion hsa04530 Tight junction MICB 253.27393310244 290.885605349444 215.662260855437 0.741398876016431 -0.431678166898827 0.0405469520310487 0.759435523043776 4.38821 4.27833 3.32517 3.13416 GeneID:4277,Genbank:NM_001289160.1,HGNC:HGNC:7091,IMGT/GENE-DB:MICB,MIM:602436 MHC class I polypeptide-related sequence B GO:0001913,GO:0002429,GO:0005886,GO:0006979,GO:0009408,GO:0009986,GO:0016021,GO:0016032,GO:0019835,GO:0032526,GO:0042267,GO:0046629,GO:0046703,GO:0050689,GO:0050776 T cell mediated cytotoxicity|immune response-activating cell surface receptor signaling pathway|plasma membrane|response to oxidative stress|response to heat|cell surface|integral component of membrane|viral process|cytolysis|response to retinoic acid|natural killer cell mediated cytotoxicity|gamma-delta T cell activation|natural killer cell lectin-like receptor binding|negative regulation of defense response to virus by host|regulation of immune response hsa04650,hsa05167 Natural killer cell mediated cytotoxicity|Kaposi sarcoma-associated herpesvirus infection MICU1 2373.06785600651 2224.16309073196 2521.97262128106 1.13389734403474 0.181290033617109 0.194379345311707 1 21.8149 22.7748 25.4436 25.0832 GeneID:10367,Genbank:NM_001195518.1,HGNC:HGNC:1530,MIM:605084 mitochondrial calcium uptake 1 GO:0005509,GO:0005622,GO:0005739,GO:0005743,GO:0005758,GO:0006851,GO:0006952,GO:0032592,GO:0034704,GO:0036444,GO:0042802,GO:0046982,GO:0051260,GO:0051560,GO:0051561,GO:0070509,GO:1990246 calcium ion binding|intracellular|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial calcium ion transmembrane transport|defense response|integral component of mitochondrial membrane|calcium channel complex|mitochondrial calcium uptake|identical protein binding|protein heterodimerization activity|protein homooligomerization|mitochondrial calcium ion homeostasis|positive regulation of mitochondrial calcium ion concentration|calcium ion import|uniplex complex MICU2 439.027756307792 460.273754634748 417.781757980835 0.907681034979645 -0.139742680737746 0.452456464711106 1 7.2657 7.37805 7.5859 5.87108 GeneID:221154,Genbank:NM_152726.2,HGNC:HGNC:31830,MIM:610632 mitochondrial calcium uptake 2 GO:0005509,GO:0005739,GO:0005743,GO:0005758,GO:0006851,GO:0034704,GO:0036444,GO:0046982,GO:0051560,GO:0051561,GO:0051562,GO:1990246 calcium ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial calcium ion transmembrane transport|calcium channel complex|mitochondrial calcium uptake|protein heterodimerization activity|mitochondrial calcium ion homeostasis|positive regulation of mitochondrial calcium ion concentration|negative regulation of mitochondrial calcium ion concentration|uniplex complex MICU3 29.3058867683344 34.8616961230188 23.75007741365 0.681265688560921 -0.553710546553113 0.296258928652236 1 0.212988 0.220136 0.152581 0.103187 GeneID:286097,Genbank:NM_181723.2,HGNC:HGNC:27820,MIM:610633 mitochondrial calcium uptake family member 3 GO:0005509,GO:0005743,GO:0006851,GO:0016021 calcium ion binding|mitochondrial inner membrane|mitochondrial calcium ion transmembrane transport|integral component of membrane MID1 1027.49467715418 1012.3721408783 1042.61721343007 1.02987544928442 0.0424698718115651 0.87331251764247 1 4.08142 4.1229 5.25296 3.32687 GeneID:4281,Genbank:NM_033290.3,HGNC:HGNC:7095,MIM:300552 midline 1 GO:0000226,GO:0005819,GO:0005829,GO:0005874,GO:0005875,GO:0007026,GO:0007389,GO:0008017,GO:0008270,GO:0016740,GO:0031625,GO:0032874,GO:0035372,GO:0042802,GO:0042803,GO:0046982,GO:0051219,GO:0060333 microtubule cytoskeleton organization|spindle|cytosol|microtubule|microtubule associated complex|negative regulation of microtubule depolymerization|pattern specification process|microtubule binding|zinc ion binding|transferase activity|ubiquitin protein ligase binding|positive regulation of stress-activated MAPK cascade|protein localization to microtubule|identical protein binding|protein homodimerization activity|protein heterodimerization activity|phosphoprotein binding|interferon-gamma-mediated signaling pathway hsa04120 Ubiquitin mediated proteolysis MID1IP1 1019.79668726504 1116.92983728374 922.663537246332 0.826071169779254 -0.275662013164616 0.0671198102805225 0.913331250172344 13.6984 14.2248 11.0099 12.461 GeneID:58526,Genbank:NM_021242.5,HGNC:HGNC:20715,MIM:300961 MID1 interacting protein 1 GO:0005634,GO:0005829,GO:0005874,GO:0006629,GO:0006853,GO:0007026,GO:0008022,GO:0015630,GO:0042802,GO:0045723,GO:0046890,GO:0051258,GO:0051351 nucleus|cytosol|microtubule|lipid metabolic process|carnitine shuttle|negative regulation of microtubule depolymerization|protein C-terminus binding|microtubule cytoskeleton|identical protein binding|positive regulation of fatty acid biosynthetic process|regulation of lipid biosynthetic process|protein polymerization|positive regulation of ligase activity MID2 202.575459995454 207.911684941196 197.239235049711 0.948668349763491 -0.0760242792714263 0.726415805429889 1 0.593689 0.781406 0.674802 0.670149 GeneID:11043,Genbank:XM_005262062.5,HGNC:HGNC:7096,MIM:300204 midline 2 GO:0005737,GO:0005874,GO:0008017,GO:0008270,GO:0010508,GO:0016567,GO:0016740,GO:0032897,GO:0035372,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0046597,GO:0046982,GO:0051091,GO:0051092,GO:0051219,GO:0070062,GO:1902187 cytoplasm|microtubule|microtubule binding|zinc ion binding|positive regulation of autophagy|protein ubiquitination|transferase activity|negative regulation of viral transcription|protein localization to microtubule|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of viral entry into host cell|protein heterodimerization activity|positive regulation of DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|phosphoprotein binding|extracellular exosome|negative regulation of viral release from host cell MIDN 1151.81083858935 1059.14943812746 1244.47223905123 1.17497323253215 0.232627890634535 0.119057623709375 1 12.6401 11.583 13.9711 14.9702 GeneID:90007,Genbank:XM_024451753.1,HGNC:HGNC:16298,MIM:606700 midnolin GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0019900,GO:0033132,GO:0046676 nucleus|nucleolus|cytoplasm|cytosol|kinase binding|negative regulation of glucokinase activity|negative regulation of insulin secretion MIEF1 548.841866093153 565.099991378084 532.583740808223 0.94245929735273 -0.0854977818380205 0.607267450984209 1 3.81405 4.08763 3.97725 3.90045 GeneID:54471,Genbank:NM_001304564.1,HGNC:HGNC:25979,MIM:615497 mitochondrial elongation factor 1 GO:0000266,GO:0005739,GO:0005741,GO:0016021,GO:0019003,GO:0042802,GO:0043531,GO:0090141,GO:0090314 mitochondrial fission|mitochondrion|mitochondrial outer membrane|integral component of membrane|GDP binding|identical protein binding|ADP binding|positive regulation of mitochondrial fission|positive regulation of protein targeting to membrane MIEF2 293.842681362864 306.596299176548 281.08906354918 0.916805141823711 -0.125312959537345 0.54371914299174 1 5.01072 4.21846 4.36023 4.20346 GeneID:125170,Genbank:NM_139162.3,HGNC:HGNC:17920,MIM:615498 mitochondrial elongation factor 2 GO:0005739,GO:0005741,GO:0007005,GO:0016021,GO:0032464,GO:0090141,GO:0090314 mitochondrion|mitochondrial outer membrane|mitochondrion organization|integral component of membrane|positive regulation of protein homooligomerization|positive regulation of mitochondrial fission|positive regulation of protein targeting to membrane MIEN1 2033.54388587419 2003.28024362241 2063.80752812596 1.03021408746791 0.0429441731695124 0.844022693555265 1 41.5911 43.2313 39.0769 48.2492 GeneID:84299,Genbank:NM_032339.4,HGNC:HGNC:28230,MIM:611802 migration and invasion enhancer 1 MIER1 433.38686781225 476.06967535526 390.70406026924 0.820686719811933 -0.285096486803205 0.570380290554198 1 2.83231 2.01751 2.74945 1.44941 GeneID:57708,Genbank:NM_001146110.1,HGNC:HGNC:29657,MIM:616848 MIER1 transcriptional regulator GO:0003677,GO:0004871,GO:0005634,GO:0006351,GO:0017053,GO:0031937 DNA binding|signal transducer activity|nucleus|transcription, DNA-templated|transcriptional repressor complex|positive regulation of chromatin silencing MIER2 1075.32195783344 1038.90465716975 1111.73925849713 1.07010710831329 0.0977552049431371 0.540220310572952 1 5.04461 5.7693 5.95226 5.84504 GeneID:54531,Genbank:XM_006722769.4,HGNC:HGNC:29210 MIER family member 2 GO:0003677,GO:0004407,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0016575,GO:0042826,GO:0043234 DNA binding|histone deacetylase activity|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|histone deacetylation|histone deacetylase binding|protein complex MIER3 246.418228058194 272.791181096598 220.045275019789 0.806643653710596 -0.309996611673175 0.193897559480479 1 2.07995 1.78682 1.85173 1.40184 GeneID:166968,Genbank:NM_152622.4,HGNC:HGNC:26678 MIER family member 3 GO:0003677,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0043234 DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|protein complex MIF 2.02101386303638 2.10436443188427 1.93766329418849 0.920783142325533 -0.119066673999736 1 1 0.411811 0.169517 0 0.170922 GeneID:4282,Genbank:NM_002415.1,HGNC:HGNC:7097,MIM:153620 macrophage migration inhibitory factor hsa00350,hsa00360 Tyrosine metabolism|Phenylalanine metabolism MIF4GD 450.682459319694 414.814818114009 486.550100525378 1.17293326872343 0.230120936963744 0.280853806804877 1 4.45251 5.73302 5.63756 6.00885 GeneID:57409,Genbank:NM_001242501.1,HGNC:HGNC:24030,MIM:612072 MIF4G domain containing GO:0003723,GO:0005730,GO:0005829,GO:0006417,GO:0008022 RNA binding|nucleolus|cytosol|regulation of translation|protein C-terminus binding MIGA1 357.818552722616 412.718228335523 302.91887710971 0.733960499712771 -0.446225672693441 0.0216986443095034 0.600929980812952 2.39044 2.07566 1.80273 1.39398 GeneID:374986,Genbank:NM_001270384.1,HGNC:HGNC:24741,MIM:616773 mitoguardin 1 GO:0005741,GO:0005887,GO:0008053,GO:0042803,GO:0046982 mitochondrial outer membrane|integral component of plasma membrane|mitochondrial fusion|protein homodimerization activity|protein heterodimerization activity MIGA2 439.808899406688 409.058422804359 470.559376009016 1.15034760263101 0.202069868836666 0.273895229462944 1 4.03963 4.39004 4.86145 5.01038 GeneID:84895,Genbank:NM_001329990.1,HGNC:HGNC:23621,MIM:616774 mitoguardin 2 GO:0005741,GO:0005887,GO:0008053,GO:0042803,GO:0046982,GO:0060348 mitochondrial outer membrane|integral component of plasma membrane|mitochondrial fusion|protein homodimerization activity|protein heterodimerization activity|bone development MIIP 344.833820192043 354.805593012002 334.862047372084 0.943790216296724 -0.0834618788834247 0.650775502840267 1 4.75745 5.41099 4.70559 4.53853 GeneID:60672,Genbank:NM_021933.3,HGNC:HGNC:25715,MIM:608772 migration and invasion inhibitory protein GO:0010972,GO:0030336 negative regulation of G2/M transition of mitotic cell cycle|negative regulation of cell migration MILR1 62.3721138086661 68.0512642863177 56.6929633310145 0.833091992126487 -0.263452284462251 0.4947970293856 1 0.521417 0.5033 0.374375 0.582231 GeneID:284021,Genbank:XM_024450706.1,HGNC:HGNC:27570 mast cell immunoglobulin like receptor 1 GO:0005887,GO:0033004,GO:0042629,GO:0043303 integral component of plasma membrane|negative regulation of mast cell activation|mast cell granule|mast cell degranulation MINDY1 574.381099229604 497.951417655672 650.810780803536 1.30697645940545 0.386233156278822 0.0224811298063962 0.610267415219053 3.70756 3.82208 4.8405 5.41608 GeneID:55793,Genbank:XM_017001772.2,HGNC:HGNC:25648 MINDY lysine 48 deubiquitinase 1 GO:0004843,GO:0005634,GO:0005654,GO:0016604,GO:0016807,GO:0036435,GO:0070062,GO:1990380 thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|nuclear body|cysteine-type carboxypeptidase activity|K48-linked polyubiquitin modification-dependent protein binding|extracellular exosome|Lys48-specific deubiquitinase activity MINDY2 151.149766261737 153.48535035946 148.814182164014 0.969566032298806 -0.0445889384573481 0.925190533931625 1 0.715068 0.631424 0.849048 0.500387 GeneID:54629,Genbank:NM_001040450.2,HGNC:HGNC:26954 MINDY lysine 48 deubiquitinase 2 GO:0004843,GO:0005654,GO:0016807,GO:0036435,GO:0070530,GO:0071795,GO:0071796,GO:1990380 thiol-dependent ubiquitin-specific protease activity|nucleoplasm|cysteine-type carboxypeptidase activity|K48-linked polyubiquitin modification-dependent protein binding|K63-linked polyubiquitin modification-dependent protein binding|K11-linked polyubiquitin modification-dependent protein binding|K6-linked polyubiquitin modification-dependent protein binding|Lys48-specific deubiquitinase activity MINDY3 365.18577712199 382.392653344814 347.978900899166 0.910004148498596 -0.136054972647777 0.477652377055202 1 1.2424 1.32789 1.38108 1.18603 GeneID:80013,Genbank:NM_001318330.1,HGNC:HGNC:23578,MIM:611649 MINDY lysine 48 deubiquitinase 3 GO:0005654,GO:0006915,GO:0016807,GO:0031965,GO:0036459,GO:1990380 nucleoplasm|apoptotic process|cysteine-type carboxypeptidase activity|nuclear membrane|thiol-dependent ubiquitinyl hydrolase activity|Lys48-specific deubiquitinase activity MINDY4 111.723200514629 123.130349403427 100.316051625831 0.814714261040166 -0.295633933042884 0.313072307472458 1 1.43828 1.15976 1.08223 1.08057 GeneID:84182,Genbank:NM_032222.2,HGNC:HGNC:21916 MINDY lysine 48 deubiquitinase 4 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity MINK1 2555.57161262448 2432.05719236465 2679.08603288432 1.10157197013919 0.1395637552031 0.326787356838743 1 12.8281 14.1599 15.9803 14.6585 GeneID:50488,Genbank:NM_001321236.1,HGNC:HGNC:17565,MIM:609426 misshapen like kinase 1 GO:0001952,GO:0004672,GO:0004674,GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0006468,GO:0006950,GO:0007254,GO:0007268,GO:0007275,GO:0007346,GO:0008349,GO:0014069,GO:0022407,GO:0030054,GO:0030334,GO:0030424,GO:0030425,GO:0031532,GO:0035556,GO:0042981,GO:0045211,GO:0046330,GO:0046777,GO:0048812,GO:0048813,GO:0070062,GO:2000311 regulation of cell-matrix adhesion|protein kinase activity|protein serine/threonine kinase activity|ATP binding|cytoplasm|Golgi apparatus|cytosol|protein phosphorylation|response to stress|JNK cascade|chemical synaptic transmission|multicellular organism development|regulation of mitotic cell cycle|MAP kinase kinase kinase kinase activity|postsynaptic density|regulation of cell-cell adhesion|cell junction|regulation of cell migration|axon|dendrite|actin cytoskeleton reorganization|intracellular signal transduction|regulation of apoptotic process|postsynaptic membrane|positive regulation of JNK cascade|protein autophosphorylation|neuron projection morphogenesis|dendrite morphogenesis|extracellular exosome|regulation of AMPA receptor activity MINOS1 704.755499973661 749.988129082392 659.52287086493 0.879377746514274 -0.185445070637597 0.246095252352307 1 9.48483 9.71096 8.1129 9.80876 GeneID:440574,Genbank:NM_001204083.1,HGNC:HGNC:32068,MIM:616574 mitochondrial inner membrane organizing system 1 GO:0005739,GO:0061617 mitochondrion|MICOS complex MINOS1-NBL1 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 3.40423 4.81323 4.6876 5.26684 GeneID:100532736,Genbank:NM_001204088.1,HGNC:HGNC:48338 MINOS1-NBL1 readthrough GO:0005615,GO:0007399,GO:0016015,GO:0030514,GO:0035582,GO:0036122,GO:0038098,GO:0042803,GO:0045666,GO:0048263,GO:0048812,GO:0090027 extracellular space|nervous system development|morphogen activity|negative regulation of BMP signaling pathway|sequestering of BMP in extracellular matrix|BMP binding|sequestering of BMP from receptor via BMP binding|protein homodimerization activity|positive regulation of neuron differentiation|determination of dorsal identity|neuron projection morphogenesis|negative regulation of monocyte chemotaxis hsa04350 TGF-beta signaling pathway MINPP1 545.752736690211 557.411719425074 534.093753955348 0.958167428747683 -0.0616503225179397 0.738357711907908 1 7.72354 7.79629 8.0966 7.02479 GeneID:9562,Genbank:NM_004897.4,HGNC:HGNC:7102,MIM:605391 multiple inositol-polyphosphate phosphatase 1 GO:0001503,GO:0003993,GO:0005783,GO:0005788,GO:0006797,GO:0030282,GO:0030351,GO:0034417,GO:0043647,GO:0051717,GO:0052745,GO:0052826,GO:0070062,GO:0101006 ossification|acid phosphatase activity|endoplasmic reticulum|endoplasmic reticulum lumen|polyphosphate metabolic process|bone mineralization|inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity|bisphosphoglycerate 3-phosphatase activity|inositol phosphate metabolic process|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|inositol phosphate phosphatase activity|inositol hexakisphosphate 2-phosphatase activity|extracellular exosome|protein histidine phosphatase activity hsa00010,hsa00562 Glycolysis / Gluconeogenesis|Inositol phosphate metabolism MIOS 330.087749224985 347.569174841372 312.606323608599 0.899407502841038 -0.152953175894432 0.444843940749369 1 2.21047 2.10924 2.22749 1.7768 GeneID:54468,Genbank:XM_005249780.3,HGNC:HGNC:21905,MIM:615359 meiosis regulator for oocyte development GO:0005634,GO:0005654,GO:0005765,GO:0005829,GO:0030054,GO:0032008,GO:0034198,GO:0034629,GO:0061700 nucleus|nucleoplasm|lysosomal membrane|cytosol|cell junction|positive regulation of TOR signaling|cellular response to amino acid starvation|cellular protein complex localization|GATOR2 complex hsa04150 mTOR signaling pathway MIOX 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:55586,Genbank:XM_011530705.2,HGNC:HGNC:14522,MIM:606774 myo-inositol oxygenase GO:0004033,GO:0005737,GO:0005829,GO:0008199,GO:0016234,GO:0016651,GO:0016701,GO:0019310,GO:0043647,GO:0050113,GO:0070062 aldo-keto reductase (NADP) activity|cytoplasm|cytosol|ferric iron binding|inclusion body|oxidoreductase activity, acting on NAD(P)H|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen|inositol catabolic process|inositol phosphate metabolic process|inositol oxygenase activity|extracellular exosome hsa00053,hsa00562 Ascorbate and aldarate metabolism|Inositol phosphate metabolism MIP 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0155632 0 0 GeneID:4284,Genbank:XM_011538354.1,HGNC:HGNC:7103,MIM:154050 major intrinsic protein of lens fiber GO:0002088,GO:0005212,GO:0005516,GO:0005783,GO:0005886,GO:0005887,GO:0005921,GO:0006833,GO:0007601,GO:0015250,GO:0016324,GO:0034220,GO:0045785,GO:0050896,GO:0051289,GO:1990349 lens development in camera-type eye|structural constituent of eye lens|calmodulin binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|gap junction|water transport|visual perception|water channel activity|apical plasma membrane|ion transmembrane transport|positive regulation of cell adhesion|response to stimulus|protein homotetramerization|gap junction-mediated intercellular transport MIPEP 396.183949895095 404.705615116536 387.662284673654 0.957887091737103 -0.0620724825488823 0.761343509909683 1 3.83578 4.6802 3.91695 4.3992 GeneID:4285,Genbank:NM_005932.3,HGNC:HGNC:7104,MIM:602241 mitochondrial intermediate peptidase GO:0004222,GO:0005739,GO:0005759,GO:0006518,GO:0006627,GO:0046872 metalloendopeptidase activity|mitochondrion|mitochondrial matrix|peptide metabolic process|protein processing involved in protein targeting to mitochondrion|metal ion binding MIPOL1 33.8412715524816 44.4131841336334 23.2693589713298 0.523929086041555 -0.932556539116092 0.0550791716824642 0.855410907895938 0.0461181 0.0550077 0.0323436 0.0217541 GeneID:145282,Genbank:XM_017021004.1,HGNC:HGNC:21460,MIM:606850 mirror-image polydactyly 1 GO:0005634,GO:0042802 nucleus|identical protein binding MIS12 514.351659538777 559.573918786751 469.129400290803 0.838368952770268 -0.254342804197282 0.146422292707034 1 5.10429 5.07269 4.36531 3.86107 GeneID:79003,Genbank:NM_001258217.1,HGNC:HGNC:24967,MIM:609178 MIS12, kinetochore complex component GO:0000444,GO:0000777,GO:0000818,GO:0005634,GO:0005829,GO:0007059,GO:0007062,GO:0034501,GO:0051301,GO:0051315,GO:0051382 MIS12/MIND type complex|condensed chromosome kinetochore|nuclear MIS12/MIND complex|nucleus|cytosol|chromosome segregation|sister chromatid cohesion|protein localization to kinetochore|cell division|attachment of mitotic spindle microtubules to kinetochore|kinetochore assembly MIS18A 338.330437387516 366.509471729185 310.151403045847 0.846230253157056 -0.24087783119799 0.203256765629598 1 7.39225 8.90637 6.69199 7.16048 GeneID:54069,Genbank:XM_017028402.1,HGNC:HGNC:1286 MIS18 kinetochore protein A GO:0000775,GO:0000785,GO:0005634,GO:0005654,GO:0005829,GO:0007049,GO:0007059,GO:0034080,GO:0044030,GO:0046872,GO:0051301,GO:1903955 chromosome, centromeric region|chromatin|nucleus|nucleoplasm|cytosol|cell cycle|chromosome segregation|CENP-A containing nucleosome assembly|regulation of DNA methylation|metal ion binding|cell division|positive regulation of protein targeting to mitochondrion MIS18BP1 98.1757978571507 105.699501341918 90.6520943723834 0.857639754412284 -0.221556313900243 0.651107032613521 1 0.45383 0.358196 0.475725 0.233207 GeneID:55320,Genbank:XM_005267833.5,HGNC:HGNC:20190 MIS18 binding protein 1 GO:0000778,GO:0003677,GO:0005654,GO:0007049,GO:0034080,GO:0051301 condensed nuclear chromosome kinetochore|DNA binding|nucleoplasm|cell cycle|CENP-A containing nucleosome assembly|cell division MISP 1.72882185942616 1.51824048055703 1.93940323829528 1.27740187614003 0.353212474534228 1 1 0 0.0206178 0.0330227 0.0103064 GeneID:126353,Genbank:XM_011527685.2,HGNC:HGNC:27000,MIM:615289 mitotic spindle positioning GO:0003779,GO:0005856,GO:0005886,GO:0005925,GO:0005938,GO:0007049,GO:0043231,GO:0051301 actin binding|cytoskeleton|plasma membrane|focal adhesion|cell cortex|cell cycle|intracellular membrane-bounded organelle|cell division MISP3 33.9997439879219 29.7208507300204 38.2786372458234 1.28793881418606 0.365064057297962 0.468387747060188 1 0.964001 0.800379 0.874351 2.01624 GeneID:113230,Genbank:NM_001291291.1,HGNC:HGNC:26963 MISP family member 3 MITD1 264.524410533824 304.684039843404 224.364781224243 0.736385080556102 -0.441467697457783 0.0346643901337334 0.730000079237491 4.27985 4.29857 3.2603 3.34524 GeneID:129531,Genbank:XM_017003314.2,HGNC:HGNC:25207 microtubule interacting and trafficking domain containing 1 GO:0000281,GO:0000920,GO:0019898,GO:0019904,GO:0030496,GO:0031902,GO:0032091,GO:0035091,GO:0042803,GO:0043231,GO:0070062 mitotic cytokinesis|cell separation after cytokinesis|extrinsic component of membrane|protein domain specific binding|midbody|late endosome membrane|negative regulation of protein binding|phosphatidylinositol binding|protein homodimerization activity|intracellular membrane-bounded organelle|extracellular exosome MITF 241.585730725151 251.497596749223 231.67386470108 0.92117725058061 -0.11844931215413 0.608103795316085 1 1.60259 1.34282 1.50148 1.18736 GeneID:4286,Genbank:NM_001354607.1,HGNC:HGNC:7105,MIM:156845 melanogenesis associated transcription factor GO:0000122,GO:0000978,GO:0001077,GO:0001227,GO:0003682,GO:0003705,GO:0005634,GO:0005654,GO:0006355,GO:0006461,GO:0010628,GO:0016925,GO:0030316,GO:0030318,GO:0042127,GO:0043010,GO:0043234,GO:0044336,GO:0045165,GO:0045670,GO:0045893,GO:0045944,GO:0046849,GO:0046983,GO:0070888,GO:2000144,GO:2001141 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|protein complex assembly|positive regulation of gene expression|protein sumoylation|osteoclast differentiation|melanocyte differentiation|regulation of cell proliferation|camera-type eye development|protein complex|canonical Wnt signaling pathway involved in negative regulation of apoptotic process|cell fate commitment|regulation of osteoclast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|bone remodeling|protein dimerization activity|E-box binding|positive regulation of DNA-templated transcription, initiation|regulation of RNA biosynthetic process hsa04137,hsa04380,hsa04916,hsa05200,hsa05202,hsa05218 Mitophagy - animal|Osteoclast differentiation|Melanogenesis|Pathways in cancer|Transcriptional misregulation in cancer|Melanoma MKI67 5089.81059974627 5042.38027582533 5137.24092366721 1.01881267231999 0.0268888095416899 0.932429643208623 1 9.88217 8.87071 12.243 7.09364 GeneID:4288,Genbank:NM_001145966.1,HGNC:HGNC:7107,MIM:176741 marker of proliferation Ki-67 MKKS 909.644252245513 907.652782340297 911.63572215073 1.0043881756195 0.00631694937763624 0.965637177611674 1 9.71209 9.97273 10.6578 9.3258 GeneID:8195,Genbank:NM_170784.2,HGNC:HGNC:7108,MIM:604896 McKusick-Kaufman syndrome MKL1 895.731805294396 893.951417396561 897.512193192231 1.00398318714684 0.00573510990324959 0.99306782194727 1 4.09525 4.42605 4.54919 4.50787 GeneID:57591,Genbank:NM_001282661.1,HGNC:HGNC:14334,MIM:606078 megakaryoblastic leukemia (translocation) 1 MKL2 339.327075489833 355.870962709324 322.783188270342 0.907023112571261 -0.140788781215042 0.501933647793273 1 0.710021 0.567048 0.654546 0.538256 GeneID:57496,Genbank:XM_017023501.2,HGNC:HGNC:29819,MIM:609463 MKL1/myocardin like 2 GO:0001105,GO:0003713,GO:0005634,GO:0007517,GO:0045296,GO:0045844,GO:0045944,GO:0051145 RNA polymerase II transcription coactivator activity|transcription coactivator activity|nucleus|muscle organ development|cadherin binding|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation MKLN1 762.439576749697 747.429876866418 777.449276632977 1.04016349987562 0.0568103186741896 0.810993006902465 1 2.61548 2.11806 3.01403 2.0083 GeneID:4289,Genbank:NM_001145354.1,HGNC:HGNC:7109,MIM:605623 muskelin 1 GO:0001726,GO:0005829,GO:0005938,GO:0007160,GO:0007165,GO:0008360,GO:0031532,GO:0042802 ruffle|cytosol|cell cortex|cell-matrix adhesion|signal transduction|regulation of cell shape|actin cytoskeleton reorganization|identical protein binding MKNK1 652.101971852031 693.102645836616 611.101297867446 0.881689460483607 -0.181657480724101 0.259736192876368 1 1.8367 1.92538 1.72874 1.73429 GeneID:8569,Genbank:XM_024450513.1,HGNC:HGNC:7110,MIM:606724 MAP kinase interacting serine/threonine kinase 1 GO:0004674,GO:0004683,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006417,GO:0006468,GO:0009931,GO:0018105,GO:0035556,GO:0046777,GO:0046872 protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of translation|protein phosphorylation|calcium-dependent protein serine/threonine kinase activity|peptidyl-serine phosphorylation|intracellular signal transduction|protein autophosphorylation|metal ion binding hsa04010,hsa04066,hsa04910 MAPK signaling pathway|HIF-1 signaling pathway|Insulin signaling pathway MKNK2 1734.75953362747 1474.50337091896 1995.01569633598 1.35300856931416 0.436170976689096 0.0510574024787296 0.82804521131659 15.4357 16.295 19.7998 23.6832 GeneID:2872,Genbank:XM_024451471.1,HGNC:HGNC:7111,MIM:605069 MAP kinase interacting serine/threonine kinase 2 GO:0004674,GO:0004683,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006417,GO:0006468,GO:0007166,GO:0009931,GO:0016604,GO:0016605,GO:0018105,GO:0030097,GO:0035556,GO:0046777,GO:0046872,GO:0071243,GO:0097192 protein serine/threonine kinase activity|calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|regulation of translation|protein phosphorylation|cell surface receptor signaling pathway|calcium-dependent protein serine/threonine kinase activity|nuclear body|PML body|peptidyl-serine phosphorylation|hemopoiesis|intracellular signal transduction|protein autophosphorylation|metal ion binding|cellular response to arsenic-containing substance|extrinsic apoptotic signaling pathway in absence of ligand hsa04010,hsa04066,hsa04910 MAPK signaling pathway|HIF-1 signaling pathway|Insulin signaling pathway MKRN1 3330.3056936997 3210.08220156052 3450.52918583887 1.07490368444816 0.104207394517786 0.447361706907687 1 27.5343 29.7749 32.0947 30.5158 GeneID:23608,Genbank:NM_013446.3,HGNC:HGNC:7112,MIM:607754 makorin ring finger protein 1 GO:0000209,GO:0003723,GO:0004842,GO:0005829,GO:0043491,GO:0046872,GO:0061630 protein polyubiquitination|RNA binding|ubiquitin-protein transferase activity|cytosol|protein kinase B signaling|metal ion binding|ubiquitin protein ligase activity MKRN2 1419.6382109508 1530.82910517617 1308.44731672543 0.854731146867533 -0.226457398955147 0.122837497913616 1 24.0009 23.0673 19.9377 20.7073 GeneID:23609,Genbank:NM_014160.4,HGNC:HGNC:7113,MIM:608426 makorin ring finger protein 2 GO:0003723,GO:0005622,GO:0016567,GO:0016740,GO:0046872 RNA binding|intracellular|protein ubiquitination|transferase activity|metal ion binding MKRN2OS 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0132099 GeneID:100129480,Genbank:XM_006712909.4,HGNC:HGNC:40375 MKRN2 opposite strand MKRN3 108.980077504678 100.184254406548 117.775900602809 1.17559292426207 0.233388580737858 0.433968484634067 1 1.39233 1.60503 2.09157 1.59651 GeneID:7681,Genbank:NM_005664.3,HGNC:HGNC:7114,MIM:603856 makorin ring finger protein 3 GO:0016567,GO:0016740,GO:0030529,GO:0042802,GO:0046872 protein ubiquitination|transferase activity|intracellular ribonucleoprotein complex|identical protein binding|metal ion binding MKS1 300.575059710465 298.304319963705 302.845799457224 1.01522431687906 0.0217985304585988 0.964170958036601 1 2.28158 2.58859 1.87785 3.01599 GeneID:54903,Genbank:NM_001165927.1,HGNC:HGNC:7121,MIM:609883 Meckel syndrome, type 1 GO:0001843,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0007368,GO:0010669,GO:0016020,GO:0036038,GO:0036064,GO:0042733,GO:0044458,GO:0048706,GO:0048754,GO:0060122,GO:0060271,GO:0060322,GO:0060828,GO:0061009,GO:0097711,GO:1901620,GO:1905515,GO:1990403,GO:2000095 neural tube closure|cytoplasm|centrosome|centriole|cytosol|determination of left/right symmetry|epithelial structure maintenance|membrane|MKS complex|ciliary basal body|embryonic digit morphogenesis|motile cilium assembly|embryonic skeletal system development|branching morphogenesis of an epithelial tube|inner ear receptor cell stereocilium organization|cilium assembly|head development|regulation of canonical Wnt signaling pathway|common bile duct development|ciliary basal body-plasma membrane docking|regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|non-motile cilium assembly|embryonic brain development|regulation of Wnt signaling pathway, planar cell polarity pathway MLC1 81.0990165414105 52.6865630371156 109.511470045705 2.07854647813255 1.05557500825656 0.00137004929224402 0.124674485594206 0.473805 0.458464 0.905405 1.06944 GeneID:23209,Genbank:NM_015166.3,HGNC:HGNC:17082,MIM:605908 megalencephalic leukoencephalopathy with subcortical cysts 1 MLEC 7058.16720995115 6417.89634255489 7698.43807734741 1.19952670882228 0.262465281229896 0.0464980251070656 0.79332376136203 24.4079 25.9112 32.0213 29.5894 GeneID:9761,Genbank:NM_014730.3,HGNC:HGNC:28973,MIM:613802 malectin GO:0005783,GO:0005789,GO:0005886,GO:0005975,GO:0006457,GO:0016020,GO:0016021,GO:0019899,GO:0030246,GO:0035579,GO:0043312 endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|carbohydrate metabolic process|protein folding|membrane|integral component of membrane|enzyme binding|carbohydrate binding|specific granule membrane|neutrophil degranulation MLF1 147.090678620343 154.609571987429 139.571785253256 0.902737026298756 -0.147622313281924 0.589693512409617 1 1.72321 1.4019 1.43249 1.50738 GeneID:4291,Genbank:XM_011512852.3,HGNC:HGNC:7125,MIM:601402 myeloid leukemia factor 1 hsa05202 Transcriptional misregulation in cancer MLF2 6147.64255814295 5920.34402875608 6374.94108752983 1.07678558147393 0.106730997011715 0.454477308247162 1 102.449 108.637 111.44 117.132 GeneID:8079,Genbank:XM_024449201.1,HGNC:HGNC:7126,MIM:601401 myeloid leukemia factor 2 GO:0005634,GO:0005737,GO:0006952,GO:0016020 nucleus|cytoplasm|defense response|membrane MLH1 1809.89265516977 1783.10594797632 1836.67936236322 1.03004499785765 0.0427073633969105 0.762299179023099 1 16.4481 15.6104 16.5463 17.3506 GeneID:4292,Genbank:NM_001354619.1,HGNC:HGNC:7127,MIM:120436 mutL homolog 1 hsa01524,hsa03430,hsa03460,hsa05200,hsa05210,hsa05213,hsa05226 Platinum drug resistance|Mismatch repair|Fanconi anemia pathway|Pathways in cancer|Colorectal cancer|Endometrial cancer|Gastric cancer MLH3 38.9124241948288 46.8057062136273 31.0191421760304 0.662721379193703 -0.593525633811294 0.199231146216996 1 0.201842 0.198714 0.14581 0.113109 GeneID:27030,Genbank:NM_014381.2,HGNC:HGNC:7128,MIM:604395 mutL homolog 3 hsa03430 Mismatch repair MLIP 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:90523,Genbank:XM_024446579.1,HGNC:HGNC:21355,MIM:614106 muscular LMNA interacting protein GO:0000122,GO:0005634,GO:0005635,GO:0010614,GO:0016605,GO:0031981,GO:0042383,GO:0045944,GO:1903243 negative regulation of transcription from RNA polymerase II promoter|nucleus|nuclear envelope|negative regulation of cardiac muscle hypertrophy|PML body|nuclear lumen|sarcolemma|positive regulation of transcription from RNA polymerase II promoter|negative regulation of cardiac muscle hypertrophy in response to stress MLKL 216.866170501968 207.363778609446 226.36856239449 1.09164948629162 0.126509700979076 0.7233592582141 1 1.94126 2.2727 2.86192 1.7745 GeneID:197259,Genbank:NM_001142497.2,HGNC:HGNC:26617,MIM:615153 mixed lineage kinase domain like pseudokinase GO:0004871,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0019901,GO:0032403,GO:0035556,GO:0042802,GO:0070207,GO:0070266 signal transducer activity|ATP binding|cytoplasm|cytosol|plasma membrane|protein kinase binding|protein complex binding|intracellular signal transduction|identical protein binding|protein homotrimerization|necroptotic process hsa04217,hsa04668 Necroptosis|TNF signaling pathway MLLT1 2732.9405772897 2536.27667084559 2929.60448373381 1.15508079911372 0.207993773202835 0.136068932925139 1 18.0829 18.5636 22.1628 20.742 GeneID:4298,Genbank:NM_005934.3,HGNC:HGNC:7134,MIM:159556 MLLT1, super elongation complex subunit hsa05202 Transcriptional misregulation in cancer MLLT10 455.639217297435 477.992760344367 433.285674250503 0.906469114591495 -0.141670229892861 0.444160659451243 1 1.66496 1.54297 1.64417 1.28505 GeneID:8028,Genbank:XM_024448182.1,HGNC:HGNC:16063,MIM:602409 MLLT10, histone lysine methyltransferase DOT1L cofactor MLLT11 3921.30910406232 3729.68097079487 4112.93723732978 1.10275845830675 0.141116826138953 0.290669164480357 1 72.447 73.1169 80.4881 80.9675 GeneID:10962,Genbank:NM_006818.3,HGNC:HGNC:16997,MIM:604684 MLLT11, transcription factor 7 cofactor MLLT3 205.794451718101 182.322110834936 229.266792601266 1.25748210982941 0.330537874985876 0.266202127414833 1 1.01386 0.864868 1.50376 0.995066 GeneID:4300,Genbank:NM_004529.3,HGNC:HGNC:7136,MIM:159558 MLLT3, super elongation complex subunit hsa05202 Transcriptional misregulation in cancer MLLT6 3183.0127925933 2930.38301156269 3435.64257362391 1.17242099755137 0.229490711413682 0.0958363259806989 1 15.1056 15.9237 19.4517 17.5591 GeneID:4302,Genbank:NM_005937.3,HGNC:HGNC:7138,MIM:600328 MLLT6, PHD finger containing MLPH 64.3956613169001 72.5677681084118 56.2235545253885 0.774773098180364 -0.36815423360956 0.304305837824308 1 0.244701 0.220505 0.214052 0.195159 GeneID:79083,Genbank:NM_001281474.1,HGNC:HGNC:29643,MIM:606526 melanophilin MLST8 1256.50237203935 1237.03351438116 1275.97122969753 1.0314766858486 0.0447112127990688 0.778442777016059 1 11.9276 12.1372 12.7516 13.0109 GeneID:64223,Genbank:XM_024450377.1,HGNC:HGNC:24825,MIM:612190 MTOR associated protein, LST8 homolog GO:0005654,GO:0005737,GO:0005829,GO:0007050,GO:0016241,GO:0030838,GO:0031931,GO:0031932,GO:0032008,GO:0032148,GO:0032956,GO:0038202,GO:0043087,GO:0043539,GO:0050731,GO:1900034 nucleoplasm|cytoplasm|cytosol|cell cycle arrest|regulation of macroautophagy|positive regulation of actin filament polymerization|TORC1 complex|TORC2 complex|positive regulation of TOR signaling|activation of protein kinase B activity|regulation of actin cytoskeleton organization|TORC1 signaling|regulation of GTPase activity|protein serine/threonine kinase activator activity|positive regulation of peptidyl-tyrosine phosphorylation|regulation of cellular response to heat hsa04136,hsa04140,hsa04150,hsa04151,hsa04714 Autophagy - other|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Thermogenesis MLX 2890.70607883834 3025.44298688389 2755.96917079278 0.910930790215067 -0.134586648331504 0.325162192219982 1 40.7879 40.1422 36.8585 38.4152 GeneID:6945,Genbank:NM_170607.2,HGNC:HGNC:11645,MIM:602976 MLX, MAX dimerization protein GO:0000122,GO:0000977,GO:0001227,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0008134,GO:0031965,GO:0042803,GO:0045892,GO:0045944,GO:0046982 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription factor binding|nuclear membrane|protein homodimerization activity|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity hsa04931,hsa04932 Insulin resistance|Non-alcoholic fatty liver disease (NAFLD) MLXIP 1383.03510619397 1408.13200924576 1357.93820314217 0.964354331998691 -0.0523647626518352 0.716696330628976 1 6.61195 6.49701 6.65039 6.23058 GeneID:22877,Genbank:NM_014938.5,HGNC:HGNC:17055,MIM:608090 MLX interacting protein GO:0000977,GO:0000989,GO:0001228,GO:0003700,GO:0005634,GO:0005741,GO:0045944,GO:0046983,GO:1900402 RNA polymerase II regulatory region sequence-specific DNA binding|transcription factor activity, transcription factor binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|mitochondrial outer membrane|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter hsa04931,hsa04932 Insulin resistance|Non-alcoholic fatty liver disease (NAFLD) MLXIPL 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0 0 0 0 GeneID:51085,Genbank:NM_032954.2,HGNC:HGNC:12744,MIM:605678 MLX interacting protein like GO:0001078,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0006357,GO:0008134,GO:0008284,GO:0009653,GO:0010255,GO:0033137,GO:0035538,GO:0035556,GO:0042593,GO:0045723,GO:0045821,GO:0045892,GO:0045893,GO:0045944,GO:0046889,GO:0046982,GO:0055089,GO:0070328,GO:0071157,GO:0071322,GO:0090324,GO:2000505 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription factor binding|positive regulation of cell proliferation|anatomical structure morphogenesis|glucose mediated signaling pathway|negative regulation of peptidyl-serine phosphorylation|carbohydrate response element binding|intracellular signal transduction|glucose homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of glycolytic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of lipid biosynthetic process|protein heterodimerization activity|fatty acid homeostasis|triglyceride homeostasis|negative regulation of cell cycle arrest|cellular response to carbohydrate stimulus|negative regulation of oxidative phosphorylation|regulation of energy homeostasis hsa04931,hsa04932 Insulin resistance|Non-alcoholic fatty liver disease (NAFLD) MLYCD 226.004908553535 186.90625824193 265.103558865139 1.41837711245597 0.504241161588464 0.0229916650310526 0.613948474678957 4.25023 4.82421 7.10162 5.99407 GeneID:23417,Genbank:NM_012213.2,HGNC:HGNC:7150,MIM:606761 malonyl-CoA decarboxylase GO:0002931,GO:0005102,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006085,GO:0006633,GO:0006637,GO:0010906,GO:0019395,GO:0031998,GO:0042802,GO:0046321,GO:0050080,GO:2001294 response to ischemia|receptor binding|cytoplasm|mitochondrion|mitochondrial matrix|peroxisome|peroxisomal matrix|cytosol|acetyl-CoA biosynthetic process|fatty acid biosynthetic process|acyl-CoA metabolic process|regulation of glucose metabolic process|fatty acid oxidation|regulation of fatty acid beta-oxidation|identical protein binding|positive regulation of fatty acid oxidation|malonyl-CoA decarboxylase activity|malonyl-CoA catabolic process hsa00410,hsa00640,hsa04146,hsa04152 beta-Alanine metabolism|Propanoate metabolism|Peroxisome|AMPK signaling pathway MMAA 31.4212132366339 37.1581656536428 25.6842608196249 0.69121444419598 -0.532794729307018 0.307882947544454 1 0.216769 0.198424 0.16282 0.151565 GeneID:166785,Genbank:NM_172250.2,HGNC:HGNC:18871,MIM:607481 methylmalonic aciduria (cobalamin deficiency) cblA type GO:0003924,GO:0005525,GO:0005759,GO:0009235,GO:0009236,GO:0019626,GO:0042802,GO:0042803 GTPase activity|GTP binding|mitochondrial matrix|cobalamin metabolic process|cobalamin biosynthetic process|short-chain fatty acid catabolic process|identical protein binding|protein homodimerization activity MMAB 419.793454185293 414.103215647988 425.483692722599 1.02748222337951 0.0391134338445942 0.857403775521397 1 1.61228 1.98752 1.9089 1.83092 GeneID:326625,Genbank:NM_052845.3,HGNC:HGNC:19331,MIM:607568 methylmalonic aciduria (cobalamin deficiency) cblB type GO:0005524,GO:0005759,GO:0008817,GO:0009235,GO:0009236,GO:0031419 ATP binding|mitochondrial matrix|cob(I)yrinic acid a,c-diamide adenosyltransferase activity|cobalamin metabolic process|cobalamin biosynthetic process|cobalamin binding hsa00860 Porphyrin and chlorophyll metabolism MMACHC 529.835575489338 603.227474179679 456.443676798998 0.756669243919485 -0.40226528930603 0.147109230113713 1 4.16425 3.98699 3.36545 3.54157 GeneID:25974,Genbank:NM_001330540.1,HGNC:HGNC:24525,MIM:609831 methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria GO:0005737,GO:0005739,GO:0005829,GO:0006749,GO:0009235,GO:0009236,GO:0016491,GO:0031419,GO:0032451,GO:0033787,GO:0042803,GO:0043295,GO:0055114,GO:0070988,GO:0071949 cytoplasm|mitochondrion|cytosol|glutathione metabolic process|cobalamin metabolic process|cobalamin biosynthetic process|oxidoreductase activity|cobalamin binding|demethylase activity|cyanocobalamin reductase (cyanide-eliminating) activity|protein homodimerization activity|glutathione binding|oxidation-reduction process|demethylation|FAD binding hsa04977 Vitamin digestion and absorption MMADHC 1973.79588699165 2092.85439797357 1854.73737600973 0.886223799326701 -0.174257024315398 0.21570196024012 1 62.443 67.4859 59.9987 53.7247 GeneID:27249,Genbank:NM_015702.2,HGNC:HGNC:25221,MIM:611935 methylmalonic aciduria and homocystinuria, cblD type GO:0005737,GO:0005739,GO:0005829,GO:0009108,GO:0009235 cytoplasm|mitochondrion|cytosol|coenzyme biosynthetic process|cobalamin metabolic process MMD 609.466031547879 740.18568404239 478.746379053367 0.646792270337871 -0.628625657281503 0.00218020703680709 0.167875941834146 13.5233 12.9784 7.42976 9.80772 GeneID:23531,Genbank:NM_012329.2,HGNC:HGNC:7153,MIM:604467 monocyte to macrophage differentiation associated GO:0004672,GO:0004872,GO:0005765,GO:0005794,GO:0005887,GO:0016020,GO:0019835,GO:0031902,GO:0032880,GO:0045666,GO:0045860 protein kinase activity|receptor activity|lysosomal membrane|Golgi apparatus|integral component of plasma membrane|membrane|cytolysis|late endosome membrane|regulation of protein localization|positive regulation of neuron differentiation|positive regulation of protein kinase activity MME 87.5116176284635 87.2885104764938 87.7347247804332 1.00511194774093 0.00735619539045218 0.980529179731911 1 0.372081 0.284139 0.388489 0.256522 GeneID:4311,Genbank:NM_001354642.1,HGNC:HGNC:7154,MIM:120520 membrane metalloendopeptidase GO:0001822,GO:0004222,GO:0005737,GO:0005886,GO:0005903,GO:0006508,GO:0006518,GO:0008021,GO:0008238,GO:0008270,GO:0016021,GO:0019233,GO:0030424,GO:0030425,GO:0042277,GO:0044306,GO:0045202,GO:0046449,GO:0050435,GO:0071345,GO:0071492,GO:0071493,GO:0090399 kidney development|metalloendopeptidase activity|cytoplasm|plasma membrane|brush border|proteolysis|peptide metabolic process|synaptic vesicle|exopeptidase activity|zinc ion binding|integral component of membrane|sensory perception of pain|axon|dendrite|peptide binding|neuron projection terminus|synapse|creatinine metabolic process|amyloid-beta metabolic process|cellular response to cytokine stimulus|cellular response to UV-A|cellular response to UV-B|replicative senescence hsa04614,hsa04640,hsa04974,hsa05010 Renin-angiotensin system|Hematopoietic cell lineage|Protein digestion and absorption|Alzheimer disease MMEL1 9.76778757259854 10.3297170606816 9.20585808451546 0.891201378550442 -0.166176630582008 0.924383786236715 1 0.0922269 0.0344545 0.0122259 0.102706 GeneID:79258,Genbank:XM_017002311.1,HGNC:HGNC:14668 membrane metalloendopeptidase like 1 GO:0004222,GO:0005576,GO:0016021,GO:0046872 metalloendopeptidase activity|extracellular region|integral component of membrane|metal ion binding MMGT1 1077.81688424518 1151.80809971441 1003.82566877595 0.871521626757828 -0.198391629699749 0.454991518609813 1 12.824 11.7498 13.0869 8.71334 GeneID:93380,Genbank:NM_001330000.1,HGNC:HGNC:28100 membrane magnesium transporter 1 GO:0000139,GO:0005769,GO:0005794,GO:0005886,GO:0015095,GO:0015693,GO:0016020,GO:0016021,GO:0022890,GO:0031901,GO:0072546,GO:0098655 Golgi membrane|early endosome|Golgi apparatus|plasma membrane|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane|inorganic cation transmembrane transporter activity|early endosome membrane|ER membrane protein complex|cation transmembrane transport MMP1 2.696783534467 1.51824048055703 3.87532658837698 2.55251169890764 1.35191757341154 0.558069520044957 1 0.0181262 0.0342713 0.0347796 0.0967225 GeneID:4312,Genbank:NM_001145938.1,HGNC:HGNC:7155,MIM:120353 matrix metallopeptidase 1 hsa03320,hsa04657,hsa04926,hsa05200,hsa05219,hsa05323 PPAR signaling pathway|IL-17 signaling pathway|Relaxin signaling pathway|Pathways in cancer|Bladder cancer|Rheumatoid arthritis MMP10 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0.0224049 0.0211244 0 0.0199176 GeneID:4319,Genbank:NM_002425.2,HGNC:HGNC:7156,MIM:185260 matrix metallopeptidase 10 MMP11 5.99187214913513 6.169014471598 5.81472982667226 0.942570300887304 -0.0853278701833857 1 1 0.120031 0.0830137 0.111264 0.145571 GeneID:4320,Genbank:NM_005940.4,HGNC:HGNC:7157,MIM:185261 matrix metallopeptidase 11 MMP12 1.29177983152393 1.61429302992691 0.969266633120943 0.600427936658332 -0.735936990778882 0.974657200381333 1 0.0412141 0 0.0198824 0.0184857 GeneID:4321,Genbank:NM_002426.5,HGNC:HGNC:7158,MIM:601046 matrix metallopeptidase 12 MMP13 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0294397 0 0 GeneID:4322,Genbank:NM_002427.3,HGNC:HGNC:7159,MIM:600108 matrix metallopeptidase 13 hsa04657,hsa04926,hsa04928 IL-17 signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action MMP14 4325.76034847736 3852.83297151023 4798.6877254445 1.2454959145461 0.316720289283488 0.0183635947203278 0.552840851580396 38.8015 39.228 49.4821 49.0499 GeneID:4323,Genbank:NM_004995.3,HGNC:HGNC:7160,MIM:600754 matrix metallopeptidase 14 hsa04668,hsa04912,hsa04928 TNF signaling pathway|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action MMP15 392.693439328108 314.811843150238 470.575035505977 1.49478186969416 0.579934970396087 0.00165349728710964 0.142611020336488 4.11938 3.23594 5.6613 5.46565 GeneID:4324,Genbank:NM_002428.3,HGNC:HGNC:7161,MIM:602261 matrix metallopeptidase 15 hsa04928 Parathyroid hormone synthesis, secretion and action MMP16 212.801226632084 191.527606267648 234.074846996521 1.22214677851409 0.28941756168529 0.187866196615396 1 0.403298 0.360497 0.475444 0.462379 GeneID:4325,Genbank:XM_024447154.1,HGNC:HGNC:7162,MIM:602262 matrix metallopeptidase 16 hsa04928,hsa05206 Parathyroid hormone synthesis, secretion and action|MicroRNAs in cancer MMP17 248.074216193269 249.000230465606 247.148201920933 0.992562141242962 -0.0107706671339176 0.940657518672741 1 2.84975 3.51698 3.10557 3.29143 GeneID:4326,Genbank:NM_016155.6,HGNC:HGNC:7163,MIM:602285 matrix metallopeptidase 17 GO:0001822,GO:0004222,GO:0005578,GO:0005887,GO:0006508,GO:0008047,GO:0008270,GO:0031225,GO:0042756,GO:0070006 kidney development|metalloendopeptidase activity|proteinaceous extracellular matrix|integral component of plasma membrane|proteolysis|enzyme activator activity|zinc ion binding|anchored component of membrane|drinking behavior|metalloaminopeptidase activity hsa04928 Parathyroid hormone synthesis, secretion and action MMP19 46.4912143094688 54.2048035176727 38.7776251012649 0.715390935576808 -0.483196256231657 0.247911318149449 1 0.512025 0.562457 0.470286 0.310848 GeneID:4327,Genbank:NM_001272101.1,HGNC:HGNC:7165,MIM:601807 matrix metallopeptidase 19 MMP2 7137.1382046453 7449.98497536936 6824.29143392123 0.916014120361751 -0.126558257243243 0.335320330657543 1 68.5115 67.2851 62.3399 64.6262 GeneID:4313,Genbank:NM_001302508.1,HGNC:HGNC:7166,MIM:120360 matrix metallopeptidase 2 hsa01522,hsa04670,hsa04912,hsa04915,hsa04926,hsa04933,hsa05200,hsa05205,hsa05219,hsa05418 Endocrine resistance|Leukocyte transendothelial migration|GnRH signaling pathway|Estrogen signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer|Proteoglycans in cancer|Bladder cancer|Fluid shear stress and atherosclerosis MMP23B 1.4622745707901 1.47021420587209 1.45433493570811 0.989199349250911 -0.0156668042423989 1 1 0 0 0 0 GeneID:8510,Genbank:XM_017002615.1,HGNC:HGNC:7171,MIM:603321 matrix metallopeptidase 23B GO:0000003,GO:0004222,GO:0005578,GO:0005622,GO:0005789,GO:0006508,GO:0008237,GO:0008270,GO:0016021 reproduction|metalloendopeptidase activity|proteinaceous extracellular matrix|intracellular|endoplasmic reticulum membrane|proteolysis|metallopeptidase activity|zinc ion binding|integral component of membrane MMP24 85.5999968368178 75.2582564916234 95.9417371820122 1.27483337582623 0.350308695258106 0.278230545115737 1 0.598053 0.603213 0.688725 0.944085 GeneID:10893,Genbank:NM_006690.3,HGNC:HGNC:7172,MIM:604871 matrix metallopeptidase 24 GO:0004222,GO:0005578,GO:0005887,GO:0006508,GO:0008047,GO:0008270,GO:0010001,GO:0032588,GO:0044331,GO:0045296,GO:0050965,GO:0070062,GO:0097150,GO:0098742 metalloendopeptidase activity|proteinaceous extracellular matrix|integral component of plasma membrane|proteolysis|enzyme activator activity|zinc ion binding|glial cell differentiation|trans-Golgi network membrane|cell-cell adhesion mediated by cadherin|cadherin binding|detection of temperature stimulus involved in sensory perception of pain|extracellular exosome|neuronal stem cell population maintenance|cell-cell adhesion via plasma-membrane adhesion molecules hsa04928 Parathyroid hormone synthesis, secretion and action MMP24-AS1-EDEM2 7.99648589035942 9.20549543271206 6.78747634800679 0.737328739948885 -0.439620102770969 0.712049209406318 1 8.43533e-07 5.20894e-07 0.229868 0.0787519 GeneID:111089941,Genbank:NM_001355008.1 MMP24-AS1-EDEM2 readthrough GO:0004571,GO:0005509,GO:0005783,GO:0005788,GO:0006491,GO:0016020,GO:0030968,GO:0036509,GO:0036510,GO:0036511,GO:0036512,GO:0044322,GO:0097466,GO:1904154,GO:1904382 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum lumen|N-glycan processing|membrane|endoplasmic reticulum unfolded protein response|trimming of terminal mannose on B branch|trimming of terminal mannose on C branch|trimming of first mannose on A branch|trimming of second mannose on A branch|endoplasmic reticulum quality control compartment|ubiquitin-dependent glycoprotein ERAD pathway|positive regulation of retrograde protein transport, ER to cytosol|mannose trimming involved in glycoprotein ERAD pathway MMP24OS 1799.65645282234 1621.12670465017 1978.1862009945 1.22025391064136 0.287181375254527 0.0440449719974214 0.784836632957795 41.0143 41.0389 48.6733 51.0514 GeneID:101410538,Genbank:NM_001355004.1,HGNC:HGNC:44421 MMP24 opposite strand MMP25 1.7789146977695 2.10436443188427 1.45346496365472 0.690690710046484 -0.533888275697058 0.969271251083323 1 0.0287066 0.00819973 0.0088107 0.016523 GeneID:64386,Genbank:XM_024450390.1,HGNC:HGNC:14246,MIM:608482 matrix metallopeptidase 25 GO:0004222,GO:0005578,GO:0005886,GO:0006508,GO:0006954,GO:0008270,GO:0016020,GO:0016021,GO:0031225,GO:0035579,GO:0043312,GO:0060022 metalloendopeptidase activity|proteinaceous extracellular matrix|plasma membrane|proteolysis|inflammatory response|zinc ion binding|membrane|integral component of membrane|anchored component of membrane|specific granule membrane|neutrophil degranulation|hard palate development hsa04928 Parathyroid hormone synthesis, secretion and action MMP28 26.6911263437815 32.0653465353294 21.3169061522336 0.664795751661274 -0.5890169322087 0.301139658644447 1 0.357525 0.278117 0.173815 0.311898 GeneID:79148,Genbank:XM_017025064.1,HGNC:HGNC:14366,MIM:608417 matrix metallopeptidase 28 GO:0004222,GO:0005578,GO:0005737,GO:0008270,GO:0010760,GO:0031012 metalloendopeptidase activity|proteinaceous extracellular matrix|cytoplasm|zinc ion binding|negative regulation of macrophage chemotaxis|extracellular matrix MMP3 29.3790729385972 20.4673290226234 38.2908168545709 1.87082627206737 0.903675593819874 0.0879603066016592 0.970228836454666 0.299375 0.316683 0.680984 0.550252 GeneID:4314,Genbank:NM_002422.4,HGNC:HGNC:7173,MIM:185250 matrix metallopeptidase 3 hsa04657,hsa04668,hsa05202,hsa05215,hsa05323 IL-17 signaling pathway|TNF signaling pathway|Transcriptional misregulation in cancer|Prostate cancer|Rheumatoid arthritis MMP7 14.7499798294582 17.3828217868244 12.1171378720919 0.697075424271808 -0.520613329273171 0.500216658031432 1 0.605691 0.647169 0.460777 0.390434 GeneID:4316,Genbank:NM_002423.4,HGNC:HGNC:7174,MIM:178990 matrix metallopeptidase 7 hsa04310 Wnt signaling pathway MMRN2 16.5584316155884 16.6428103563344 16.4740528748424 0.989860036984213 -0.0147035476989625 1 1 0.0839602 0.0746626 0.0785842 0.120212 GeneID:79812,Genbank:XM_006717970.4,HGNC:HGNC:19888,MIM:608925 multimerin 2 GO:0001525,GO:0005604,GO:0005615,GO:0030948,GO:0031012,GO:0070062,GO:0090051 angiogenesis|basement membrane|extracellular space|negative regulation of vascular endothelial growth factor receptor signaling pathway|extracellular matrix|extracellular exosome|negative regulation of cell migration involved in sprouting angiogenesis MMS19 2341.14112377225 2176.78106922211 2505.50117832238 1.15101202125841 0.202902901167209 0.147469751121681 1 10.7422 11.202 12.9348 12.1873 GeneID:64210,Genbank:NM_001289405.1,HGNC:HGNC:13824,MIM:614777 MMS19 homolog, cytosolic iron-sulfur assembly component MMS22L 360.252995611728 361.339200370863 359.166790852593 0.99398789415585 -0.00869981367090136 0.979982337849704 1 0.920848 0.968516 1.16036 0.644867 GeneID:253714,Genbank:NM_001350600.1,HGNC:HGNC:21475,MIM:615614 MMS22 like, DNA repair protein GO:0000724,GO:0005654,GO:0005829,GO:0031297,GO:0043596 double-strand break repair via homologous recombination|nucleoplasm|cytosol|replication fork processing|nuclear replication fork MN1 36.5108421591105 37.6482370556002 35.3734472626207 0.939577787145253 -0.0899154883424822 0.891516719314269 1 0.301873 0.213123 0.213993 0.267175 GeneID:4330,Genbank:NM_002430.2,HGNC:HGNC:7180,MIM:156100 MN1 proto-oncogene, transcriptional regulator MNAT1 438.25424764171 452.490447133223 424.018048150197 0.937076242905425 -0.0937616608911702 0.621119862276317 1 3.44496 3.04359 2.70767 3.1268 GeneID:4331,Genbank:XM_017021333.2,HGNC:HGNC:7181,MIM:602659 MNAT1, CDK activating kinase assembly factor hsa03022,hsa03420 Basal transcription factors|Nucleotide excision repair MND1 147.201413848271 157.252034095956 137.150793600587 0.872171825242633 -0.19731570873208 0.462803555987578 1 4.60468 3.59136 3.42977 3.52162 GeneID:84057,Genbank:NM_032117.3,HGNC:HGNC:24839,MIM:611422 meiotic nuclear divisions 1 GO:0003690,GO:0005634,GO:0006302,GO:0007131 double-stranded DNA binding|nucleus|double-strand break repair|reciprocal meiotic recombination MNS1 23.621083533465 27.3665462696035 19.8756207973264 0.726274357075251 -0.461413451871158 0.453131379897761 1 0.345713 0.34472 0.337985 0.169938 GeneID:55329,Genbank:NM_018365.2,HGNC:HGNC:29636,MIM:610766 meiosis specific nuclear structural 1 GO:0005635,GO:0005882,GO:0005930,GO:0007283,GO:0031514,GO:0036126,GO:0042802,GO:0044782,GO:0045724,GO:0051321,GO:0070986 nuclear envelope|intermediate filament|axoneme|spermatogenesis|motile cilium|sperm flagellum|identical protein binding|cilium organization|positive regulation of cilium assembly|meiotic cell cycle|left/right axis specification MNT 597.972041643771 569.337129206321 626.606954081221 1.10059035663937 0.138277592957173 0.411532781620998 1 2.08405 2.07143 2.35477 2.36969 GeneID:4335,Genbank:NM_020310.2,HGNC:HGNC:7188,MIM:603039 MAX network transcriptional repressor GO:0000122,GO:0000977,GO:0001227,GO:0003682,GO:0003700,GO:0003713,GO:0003714,GO:0005634,GO:0005654,GO:0006366,GO:0007275,GO:0007569,GO:0008285,GO:0046983,GO:0051726,GO:2001234 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|nucleus|nucleoplasm|transcription from RNA polymerase II promoter|multicellular organism development|cell aging|negative regulation of cell proliferation|protein dimerization activity|regulation of cell cycle|negative regulation of apoptotic signaling pathway MNX1 11.0061030440406 10.8678147373239 11.1443913507573 1.02544914687251 0.0362559487910025 1 1 0.312649 0.196607 0.213637 0.244433 GeneID:3110,Genbank:NM_005515.3,HGNC:HGNC:4979,MIM:142994 motor neuron and pancreas homeobox 1 hsa04950 Maturity onset diabetes of the young MOAP1 454.147589109516 444.995297279808 463.299880939223 1.04113433056778 0.0581562218949764 0.731683616094772 1 8.93879 7.96028 8.91266 8.70135 GeneID:64112,Genbank:NM_022151.4,HGNC:HGNC:16658,MIM:609485 modulator of apoptosis 1 GO:0001844,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0008625,GO:0008630,GO:0031625,GO:0043065,GO:0090200,GO:0097190,GO:0097192 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|extrinsic apoptotic signaling pathway via death domain receptors|intrinsic apoptotic signaling pathway in response to DNA damage|ubiquitin protein ligase binding|positive regulation of apoptotic process|positive regulation of release of cytochrome c from mitochondria|apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand MOB1A 1878.92259733091 2108.00635981296 1649.83883484887 0.782653632503869 -0.353554118438367 0.0136046218294397 0.479474674774284 18.9519 18.235 16.759 12.3765 GeneID:55233,Genbank:NM_001317110.1,HGNC:HGNC:16015,MIM:609281 MOB kinase activator 1A GO:0005634,GO:0005730,GO:0005829,GO:0035329,GO:0046872 nucleus|nucleolus|cytosol|hippo signaling|metal ion binding hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species MOB1B 177.974664423671 193.074255712674 162.875073134668 0.843587730189429 -0.245389983306724 0.622207652180989 1 1.18776 0.887162 1.13964 0.59157 GeneID:92597,Genbank:XM_011532412.2,HGNC:HGNC:29801,MIM:609282 MOB kinase activator 1B GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0019209,GO:0019900,GO:0031952,GO:0035329,GO:0046872,GO:0070062 nucleus|nucleolus|cytoplasm|cytosol|kinase activator activity|kinase binding|regulation of protein autophosphorylation|hippo signaling|metal ion binding|extracellular exosome hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species MOB2 379.320346614269 374.840685562461 383.800007666078 1.02390167996351 0.0340771873699366 0.889896102039147 1 8.11104 9.41563 8.69085 9.48383 GeneID:81532,Genbank:NM_001172223.2,HGNC:HGNC:24904,MIM:611969 MOB kinase activator 2 GO:0001934,GO:0005634,GO:0005730,GO:0005829,GO:0010976,GO:0030036,GO:0044306,GO:0046872,GO:0048471 positive regulation of protein phosphorylation|nucleus|nucleolus|cytosol|positive regulation of neuron projection development|actin cytoskeleton organization|neuron projection terminus|metal ion binding|perinuclear region of cytoplasm MOB3A 964.053222946096 956.996106458827 971.110339433365 1.01474847481539 0.0211221716414968 0.908387990987625 1 11.1297 11.2934 10.7412 12.5974 GeneID:126308,Genbank:XM_011527683.3,HGNC:HGNC:29802 MOB kinase activator 3A GO:0005622,GO:0046872 intracellular|metal ion binding MOB3B 17.0593920945344 24.4261178578593 9.69266633120943 0.396815670325226 -1.33345909573994 0.0607647927012553 0.88260138524454 0.21366 0.12117 0.0613229 0.0636004 GeneID:79817,Genbank:NM_024761.4,HGNC:HGNC:23825,MIM:617652 MOB kinase activator 3B GO:0046872 metal ion binding MOB3C 223.511203540291 186.74256210766 260.279844972922 1.39378962158004 0.479012817441589 0.039671974383334 0.756412311575568 1.86966 1.81461 3.26425 2.2743 GeneID:148932,Genbank:NM_201403.2,HGNC:HGNC:29800 MOB kinase activator 3C GO:0046872 metal ion binding MOB4 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0.00032542 0.00018678 9.23013e-05 0.000190773 GeneID:25843,Genbank:NM_199482.3,HGNC:HGNC:17261,MIM:609361 MOB family member 4, phocein GO:0005737,GO:0005794,GO:0005829,GO:0006900,GO:0016020,GO:0019900,GO:0032580,GO:0043025,GO:0043197,GO:0046872,GO:0048471 cytoplasm|Golgi apparatus|cytosol|vesicle budding from membrane|membrane|kinase binding|Golgi cisterna membrane|neuronal cell body|dendritic spine|metal ion binding|perinuclear region of cytoplasm MOBP 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.0130061 0.0118583 0 0 GeneID:4336,Genbank:NM_001278322.1,HGNC:HGNC:7189,MIM:600948 myelin-associated oligodendrocyte basic protein GO:0003779,GO:0005739,GO:0007399,GO:0017022,GO:0017137,GO:0019911,GO:0030050,GO:0030864,GO:0043209,GO:0048471 actin binding|mitochondrion|nervous system development|myosin binding|Rab GTPase binding|structural constituent of myelin sheath|vesicle transport along actin filament|cortical actin cytoskeleton|myelin sheath|perinuclear region of cytoplasm MOCS1 307.55353490897 332.098612387692 283.008457430247 0.852181993160101 -0.230766527592173 0.253119046580896 1 2.69643 2.40906 2.09999 2.3197 GeneID:4337,Genbank:NM_001075098.3,HGNC:HGNC:7190,MIM:603707 molybdenum cofactor synthesis 1 GO:0005525,GO:0005634,GO:0005829,GO:0006777,GO:0019008,GO:0032324,GO:0046872,GO:0051539,GO:0061798,GO:0061799 GTP binding|nucleus|cytosol|Mo-molybdopterin cofactor biosynthetic process|molybdopterin synthase complex|molybdopterin cofactor biosynthetic process|metal ion binding|4 iron, 4 sulfur cluster binding|GTP 3',8'-cyclase activity|cyclic pyranopterin monophosphate synthase activity hsa00790 Folate biosynthesis MOCS2 1231.34936355451 1241.50976658197 1221.18896052705 0.983632181878949 -0.0238091579630804 0.886329345432667 1 12.4761 12.5536 11.8111 12.7854 GeneID:4338,Genbank:NM_176806.3,HGNC:HGNC:7193,MIM:603708 molybdenum cofactor synthesis 2 GO:0005634,GO:0005829,GO:0006777,GO:0016607,GO:0019008,GO:0030366,GO:0032324 nucleus|cytosol|Mo-molybdopterin cofactor biosynthetic process|nuclear speck|molybdopterin synthase complex|molybdopterin synthase activity|molybdopterin cofactor biosynthetic process hsa00790,hsa04122 Folate biosynthesis|Sulfur relay system MOCS3 275.215736744326 276.116836706677 274.314636781974 0.993473053124186 -0.00944725841527147 0.954438342249257 1 4.63093 5.45165 5.58113 4.68071 GeneID:27304,Genbank:NM_014484.4,HGNC:HGNC:15765,MIM:609277 molybdenum cofactor synthesis 3 GO:0002098,GO:0002143,GO:0004792,GO:0005524,GO:0005829,GO:0006777,GO:0016779,GO:0016783,GO:0018192,GO:0032324,GO:0032447,GO:0034227,GO:0042292,GO:0046872,GO:0061604,GO:0061605 tRNA wobble uridine modification|tRNA wobble position uridine thiolation|thiosulfate sulfurtransferase activity|ATP binding|cytosol|Mo-molybdopterin cofactor biosynthetic process|nucleotidyltransferase activity|sulfurtransferase activity|enzyme active site formation via cysteine modification to L-cysteine persulfide|molybdopterin cofactor biosynthetic process|protein urmylation|tRNA thio-modification|URM1 activating enzyme activity|metal ion binding|molybdopterin-synthase sulfurtransferase activity|molybdopterin-synthase adenylyltransferase activity hsa04122 Sulfur relay system MOG 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.0144849 0 0.0275174 0 GeneID:4340,Genbank:NM_001008228.2,HGNC:HGNC:7197,MIM:159465 myelin oligodendrocyte glycoprotein MOGS 1730.91789164508 1671.12481330578 1790.71096998438 1.0715602782787 0.0997130079498278 0.511750960543649 1 25.4717 28.9818 30.3937 28.7785 GeneID:7841,Genbank:NM_001146158.1,HGNC:HGNC:24862,MIM:601336 mannosyl-oligosaccharide glucosidase GO:0004573,GO:0005783,GO:0005789,GO:0006457,GO:0006487,GO:0009311,GO:0015926,GO:0016020,GO:0016021,GO:0070062 mannosyl-oligosaccharide glucosidase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|protein N-linked glycosylation|oligosaccharide metabolic process|glucosidase activity|membrane|integral component of membrane|extracellular exosome hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum MOK 170.056980532054 152.563042485338 187.550918578769 1.22933389059014 0.297876809019612 0.216400729813941 1 0.814047 0.759999 1.08852 0.898772 GeneID:5891,Genbank:XM_017021555.2,HGNC:HGNC:9833,MIM:605762 MOK protein kinase GO:0004672,GO:0004674,GO:0004693,GO:0005524,GO:0005634,GO:0005737,GO:0005929,GO:0006468,GO:0007165,GO:0010468,GO:0035556,GO:0046872,GO:0097546 protein kinase activity|protein serine/threonine kinase activity|cyclin-dependent protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cilium|protein phosphorylation|signal transduction|regulation of gene expression|intracellular signal transduction|metal ion binding|ciliary base MON1A 434.80011742671 453.336319768191 416.263915085229 0.918223175451906 -0.123083249541952 0.503269387089828 1 7.72895 6.85125 6.56891 7.50122 GeneID:84315,Genbank:NM_001142501.1,HGNC:HGNC:28207,MIM:611464 MON1 homolog A, secretory trafficking associated GO:0005085,GO:0005829,GO:0009306,GO:0012505,GO:0016192,GO:0035658 guanyl-nucleotide exchange factor activity|cytosol|protein secretion|endomembrane system|vesicle-mediated transport|Mon1-Ccz1 complex MON1B 742.829658824031 704.901560102315 780.757757545747 1.10761246922538 0.147453200410438 0.355586281892253 1 9.59279 8.88803 10.972 10.1552 GeneID:22879,Genbank:NM_014940.3,HGNC:HGNC:25020,MIM:608954 MON1 homolog B, secretory trafficking associated GO:0005737,GO:0012505,GO:0016192,GO:0019085,GO:0019086,GO:0035658 cytoplasm|endomembrane system|vesicle-mediated transport|early viral transcription|late viral transcription|Mon1-Ccz1 complex MON2 362.655230331576 362.760371301196 362.550089361956 0.999420328250064 -0.0008365320394032 0.979223429253857 1 1.44819 1.03643 1.48018 0.996534 GeneID:23041,Genbank:XM_017019041.1,HGNC:HGNC:29177,MIM:616822 MON2 homolog, regulator of endosome-to-Golgi trafficking GO:0005829,GO:0006895,GO:0015031,GO:0070062 cytosol|Golgi to endosome transport|protein transport|extracellular exosome MORC2 979.266431622089 974.753329788024 983.779533456155 1.0092599875192 0.0132978636310262 0.937319414901208 1 4.215 4.38181 4.28187 4.42334 GeneID:22880,Genbank:NM_001303257.2,HGNC:HGNC:23573,MIM:616661 MORC family CW-type zinc finger 2 GO:0005634,GO:0005829,GO:0006631,GO:0008270 nucleus|cytosol|fatty acid metabolic process|zinc ion binding MORC3 140.135168218841 165.881214232449 114.389122205232 0.689584548404253 -0.536200646722394 0.0397207181694899 0.756441167898395 1.13347 1.10776 0.922842 0.660456 GeneID:23515,Genbank:NM_001320446.1,HGNC:HGNC:23572,MIM:610078 MORC family CW-type zinc finger 3 GO:0003723,GO:0005654,GO:0006468,GO:0007569,GO:0008270,GO:0009791,GO:0016032,GO:0016363,GO:0016605,GO:0018105,GO:0048147,GO:0050821,GO:0051457 RNA binding|nucleoplasm|protein phosphorylation|cell aging|zinc ion binding|post-embryonic development|viral process|nuclear matrix|PML body|peptidyl-serine phosphorylation|negative regulation of fibroblast proliferation|protein stabilization|maintenance of protein location in nucleus MORC4 600.791749324319 619.534100613218 582.04939803542 0.939495336026385 -0.0900420952519378 0.613049733121873 1 4.26724 3.97259 4.05549 3.79084 GeneID:79710,Genbank:XM_006724691.2,HGNC:HGNC:23485,MIM:300970 MORC family CW-type zinc finger 4 GO:0005654,GO:0008270 nucleoplasm|zinc ion binding MORF4L1 9561.29048101458 10103.3247743478 9019.25618768132 0.892701797588557 -0.16374976387204 0.210774444755622 1 154.385 157.423 141.668 137.372 GeneID:10933,Genbank:NM_206839.2,HGNC:HGNC:16989,MIM:607303 mortality factor 4 like 1 GO:0000724,GO:0005654,GO:0006338,GO:0006342,GO:0006351,GO:0016575,GO:0016580,GO:0016607,GO:0035267,GO:0040008,GO:0043967,GO:0043968,GO:0047485 double-strand break repair via homologous recombination|nucleoplasm|chromatin remodeling|chromatin silencing|transcription, DNA-templated|histone deacetylation|Sin3 complex|nuclear speck|NuA4 histone acetyltransferase complex|regulation of growth|histone H4 acetylation|histone H2A acetylation|protein N-terminus binding MORF4L2 9420.09542522558 10613.6994478401 8226.49140261105 0.775082377547928 -0.367578443385576 0.00496663123133495 0.281051935465501 162.902 166.279 121.382 136.206 GeneID:9643,Genbank:NM_001142420.1,HGNC:HGNC:16849,MIM:300409 mortality factor 4 like 2 GO:0005634,GO:0006281,GO:0006351,GO:0006355,GO:0016569,GO:0040008 nucleus|DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|covalent chromatin modification|regulation of growth MORN1 49.8044790223076 39.0223987121024 60.5865593325128 1.55260981723613 0.634695314937743 0.118877084485186 1 0.120596 0.0989643 0.161836 0.170845 GeneID:79906,Genbank:XM_011542176.2,HGNC:HGNC:25852 MORN repeat containing 1 MORN2 182.149405504302 196.640042696177 167.658768312428 0.852617635826458 -0.230029198093332 0.327153270918774 1 8.47753 10.1968 6.93713 9.00767 GeneID:729967,Genbank:NM_001145450.1,HGNC:HGNC:30166 MORN repeat containing 2 MORN3 16.1009758198176 16.7006452861273 15.5013063535079 0.928186072330052 -0.107514045225753 0.920957394158235 1 0.141183 0.336151 0.0881238 0.328535 GeneID:283385,Genbank:XM_011538213.2,HGNC:HGNC:29807 MORN repeat containing 3 GO:0005634 nucleus MORN4 279.719311432031 278.403497582193 281.03512528187 1.0094525669488 0.0135731216297941 0.972037890933281 1 4.14891 4.17679 3.60384 4.82746 GeneID:118812,Genbank:NM_001098831.1,HGNC:HGNC:24001,MIM:617736 MORN repeat containing 4 GO:0005737,GO:0032426,GO:0032433,GO:0048678 cytoplasm|stereocilium tip|filopodium tip|response to axon injury MORN5 21.83299720196 15.0765436010925 28.5894508028275 1.89628681210167 0.923177187391774 0.125042357067959 1 0 0.0130462 0.0134089 0.0248679 GeneID:254956,Genbank:XM_017014578.1,HGNC:HGNC:17841 MORN repeat containing 5 MOSMO 193.952458840492 193.084064367782 194.820853313203 1.00899498853573 0.012919008901555 0.934817838889705 1 2.03686 1.66139 2.06181 1.90405 GeneID:730094,Genbank:NM_001164579.1,HGNC:HGNC:27087 modulator of smoothened MOSPD1 486.952666082694 489.754473991344 484.150858174044 0.988558316228065 -0.0166020201302032 0.943258853318575 1 6.7206 6.56706 6.9997 6.27112 GeneID:56180,Genbank:NM_001306188.1,HGNC:HGNC:25235,MIM:300674 motile sperm domain containing 1 GO:0000122,GO:0000139,GO:0005634,GO:0005737,GO:0005789,GO:0016021,GO:0030154,GO:0045944,GO:0048471 negative regulation of transcription from RNA polymerase II promoter|Golgi membrane|nucleus|cytoplasm|endoplasmic reticulum membrane|integral component of membrane|cell differentiation|positive regulation of transcription from RNA polymerase II promoter|perinuclear region of cytoplasm MOSPD2 111.642953381073 105.507396243178 117.778510518969 1.11630572559584 0.158732195981741 0.575376031135458 1 0.767294 0.729381 1.12545 0.800261 GeneID:158747,Genbank:NM_001330241.1,HGNC:HGNC:28381 motile sperm domain containing 2 GO:0005886,GO:0005887,GO:0006935,GO:0016020,GO:0035579,GO:0043312,GO:0090023,GO:0090026 plasma membrane|integral component of plasma membrane|chemotaxis|membrane|specific granule membrane|neutrophil degranulation|positive regulation of neutrophil chemotaxis|positive regulation of monocyte chemotaxis MOSPD3 528.591838992022 520.244762117178 536.938915866866 1.0320890376325 0.0455674364684075 0.807778278060532 1 18.5925 18.5686 19.11 20.1851 GeneID:64598,Genbank:NM_001040097.1,HGNC:HGNC:25078,MIM:609125 motile sperm domain containing 3 GO:0005789,GO:0007507,GO:0016021 endoplasmic reticulum membrane|heart development|integral component of membrane MOV10 1763.48328850641 1686.75602089117 1840.21055612166 1.09097613011597 0.125619536730228 0.377598217860489 1 6.81468 6.66616 8.32067 6.79171 GeneID:4343,Genbank:NM_001286072.1,HGNC:HGNC:7200,MIM:610742 Mov10 RISC complex RNA helicase GO:0000932,GO:0003723,GO:0004386,GO:0005524,GO:0005615,GO:0005829,GO:0006351,GO:0006355,GO:0007223,GO:0035195,GO:0035279,GO:0045652 P-body|RNA binding|helicase activity|ATP binding|extracellular space|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|Wnt signaling pathway, calcium modulating pathway|gene silencing by miRNA|mRNA cleavage involved in gene silencing by miRNA|regulation of megakaryocyte differentiation MOV10L1 71.822245988582 68.0512642863177 75.5932276908462 1.11082767504211 0.151635025867374 0.657756161943841 1 0.164425 0.179717 0.191135 0.226384 GeneID:54456,Genbank:XM_011530696.1,HGNC:HGNC:7201,MIM:605794 Mov10 RISC complex RNA helicase like 1 GO:0000287,GO:0003723,GO:0004004,GO:0005524,GO:0007141,GO:0007275,GO:0007281,GO:0007283,GO:0034587,GO:0043046,GO:0043186,GO:0071546 magnesium ion binding|RNA binding|ATP-dependent RNA helicase activity|ATP binding|male meiosis I|multicellular organism development|germ cell development|spermatogenesis|piRNA metabolic process|DNA methylation involved in gamete generation|P granule|pi-body MOXD1 4184.1076476744 4013.66532489563 4354.54997045318 1.0849310089317 0.117603304202742 0.369827535859557 1 52.9749 50.8714 60.6357 52.0886 GeneID:26002,Genbank:NM_015529.3,HGNC:HGNC:21063,MIM:609000 monooxygenase DBH like 1 GO:0004500,GO:0005507,GO:0005615,GO:0005789,GO:0006589,GO:0016021,GO:0030667,GO:0042420,GO:0042421 dopamine beta-monooxygenase activity|copper ion binding|extracellular space|endoplasmic reticulum membrane|octopamine biosynthetic process|integral component of membrane|secretory granule membrane|dopamine catabolic process|norepinephrine biosynthetic process MPC1 860.723675951362 855.475908015354 865.971443887371 1.01226865160512 0.0175922257067008 0.915109063616474 1 7.85918 8.49234 7.75006 8.64214 GeneID:51660,Genbank:NM_016098.3,HGNC:HGNC:21606,MIM:614738 mitochondrial pyruvate carrier 1 GO:0005739,GO:0006850,GO:0031305,GO:0050833,GO:0061732,GO:1990830 mitochondrion|mitochondrial pyruvate transmembrane transport|integral component of mitochondrial inner membrane|pyruvate transmembrane transporter activity|mitochondrial acetyl-CoA biosynthetic process from pyruvate|cellular response to leukemia inhibitory factor MPC2 1188.53285586817 1118.53432165856 1258.53139007778 1.12516117360765 0.170131674962058 0.260237257788098 1 12.4789 14.0061 14.8424 15.7489 GeneID:25874,Genbank:NM_015415.3,HGNC:HGNC:24515,MIM:614737 mitochondrial pyruvate carrier 2 GO:0005634,GO:0005739,GO:0006850,GO:0031305,GO:0035774,GO:0050833,GO:0061732 nucleus|mitochondrion|mitochondrial pyruvate transmembrane transport|integral component of mitochondrial inner membrane|positive regulation of insulin secretion involved in cellular response to glucose stimulus|pyruvate transmembrane transporter activity|mitochondrial acetyl-CoA biosynthetic process from pyruvate MPDU1 2633.97280764672 2589.46209693891 2678.48351835452 1.0343783450319 0.048763977397209 0.736515134615763 1 49.0989 50.8478 52.2684 52.0648 GeneID:9526,Genbank:NM_001330073.1,HGNC:HGNC:7207,MIM:604041 mannose-P-dolichol utilization defect 1 GO:0005789,GO:0006457,GO:0006488,GO:0009312,GO:0016020,GO:0016021,GO:0070062 endoplasmic reticulum membrane|protein folding|dolichol-linked oligosaccharide biosynthetic process|oligosaccharide biosynthetic process|membrane|integral component of membrane|extracellular exosome MPDZ 687.840647977063 668.483405879162 707.197890074963 1.05791390460154 0.0812222224817331 0.772961500266283 1 2.12177 2.20807 2.7675 1.78846 GeneID:8777,Genbank:NM_001330637.1,HGNC:HGNC:7208,MIM:603785 multiple PDZ domain crumbs cell polarity complex component GO:0005737,GO:0005923,GO:0007155,GO:0008022,GO:0014069,GO:0016032,GO:0016324,GO:0016327,GO:0030425,GO:0031410,GO:0043220,GO:0045211 cytoplasm|bicellular tight junction|cell adhesion|protein C-terminus binding|postsynaptic density|viral process|apical plasma membrane|apicolateral plasma membrane|dendrite|cytoplasmic vesicle|Schmidt-Lanterman incisure|postsynaptic membrane hsa04530 Tight junction MPG 765.794631212552 746.577246578906 785.012015846197 1.05148130276326 0.0724231965741652 0.758691129955883 1 17.3412 17.9879 16.3314 21.0472 GeneID:4350,Genbank:NM_001015054.2,HGNC:HGNC:7211,MIM:156565 N-methylpurine DNA glycosylase hsa03410 Base excision repair MPHOSPH10 177.491802875446 192.61361027604 162.369995474853 0.842982981535705 -0.24642458910776 0.306576377144912 1 2.1126 2.09071 2.09476 1.4867 GeneID:10199,Genbank:NM_005791.2,HGNC:HGNC:7213,MIM:605503 M-phase phosphoprotein 10 GO:0000375,GO:0003723,GO:0005654,GO:0005694,GO:0005730,GO:0005732,GO:0006364,GO:0006396,GO:0008380,GO:0010923,GO:0030490,GO:0032040,GO:0034457 RNA splicing, via transesterification reactions|RNA binding|nucleoplasm|chromosome|nucleolus|small nucleolar ribonucleoprotein complex|rRNA processing|RNA processing|RNA splicing|negative regulation of phosphatase activity|maturation of SSU-rRNA|small-subunit processome|Mpp10 complex hsa03008 Ribosome biogenesis in eukaryotes MPHOSPH6 241.837135431735 268.496208338568 215.178062524903 0.801419371455585 -0.319370712688974 0.140893499336861 1 5.77475 5.45156 4.87316 4.79544 GeneID:10200,Genbank:NM_005792.2,HGNC:HGNC:7214,MIM:605500 M-phase phosphoprotein 6 GO:0000178,GO:0000460,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364 exosome (RNase complex)|maturation of 5.8S rRNA|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing hsa03018 RNA degradation MPHOSPH8 299.438856559947 302.761971855151 296.115741264742 0.978048000712621 -0.0320228232776527 0.903387199205753 1 2.19977 1.93219 2.15659 1.91438 GeneID:54737,Genbank:NM_017520.3,HGNC:HGNC:29810,MIM:611626 M-phase phosphoprotein 8 GO:0000151,GO:0000788,GO:0004842,GO:0005634,GO:0005720,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0031625,GO:0035064,GO:0044030,GO:0045892,GO:0070062 ubiquitin ligase complex|nuclear nucleosome|ubiquitin-protein transferase activity|nucleus|nuclear heterochromatin|nucleolus|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|ubiquitin protein ligase binding|methylated histone binding|regulation of DNA methylation|negative regulation of transcription, DNA-templated|extracellular exosome MPHOSPH9 239.897449680673 245.684383510635 234.11051585071 0.952891317329397 -0.0696164189381936 0.780390699220536 1 1.11977 0.97716 1.20683 0.878345 GeneID:10198,Genbank:XM_011537741.2,HGNC:HGNC:7215,MIM:605501 M-phase phosphoprotein 9 GO:0000139,GO:0005794,GO:0005814,GO:0016020 Golgi membrane|Golgi apparatus|centriole|membrane MPI 848.588173137203 842.82131245958 854.355033814827 1.01368465792777 0.019608921375448 0.917440904828066 1 8.7598 9.35273 8.84971 10.0951 GeneID:4351,Genbank:NM_001330372.1,HGNC:HGNC:7216,MIM:154550 mannose phosphate isomerase GO:0000032,GO:0004476,GO:0005737,GO:0005975,GO:0006486,GO:0008270,GO:0009298 cell wall mannoprotein biosynthetic process|mannose-6-phosphate isomerase activity|cytoplasm|carbohydrate metabolic process|protein glycosylation|zinc ion binding|GDP-mannose biosynthetic process hsa00051,hsa00520 Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism MPIG6B 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.013577 GeneID:80739,Genbank:XM_017011333.1,HGNC:HGNC:13937,MIM:606520 megakaryocyte and platelet inhibitory receptor G6b GO:0005783,GO:0005794,GO:0005886,GO:0007229,GO:0007596,GO:0008201,GO:0009968,GO:0016021,GO:0030168,GO:0030218,GO:0030219,GO:0030220,GO:0035855 endoplasmic reticulum|Golgi apparatus|plasma membrane|integrin-mediated signaling pathway|blood coagulation|heparin binding|negative regulation of signal transduction|integral component of membrane|platelet activation|erythrocyte differentiation|megakaryocyte differentiation|platelet formation|megakaryocyte development MPLKIP 691.688334875846 696.705633438841 686.671036312851 0.985597077668999 -0.0209301164912092 0.893196539812673 1 34.5233 36.5162 32.9824 38.5379 GeneID:136647,Genbank:NM_138701.3,HGNC:HGNC:16002,MIM:609188 M-phase specific PLK1 interacting protein GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0007049,GO:0030496,GO:0043231,GO:0051301 nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cell cycle|midbody|intracellular membrane-bounded organelle|cell division MPND 408.85431359956 382.02806045755 435.68056674157 1.14044127077933 0.189592154201994 0.314211582925447 1 7.98803 8.48042 10.0711 9.18177 GeneID:84954,Genbank:NM_001300862.1,HGNC:HGNC:25934 MPN domain containing GO:0008237,GO:0046872 metallopeptidase activity|metal ion binding MPP1 641.301770397069 620.092832600931 662.510708193206 1.06840568599117 0.0954595590428251 0.582218305949797 1 8.35573 9.43711 10.5462 8.93913 GeneID:4354,Genbank:NM_001166460.1,HGNC:HGNC:7219,MIM:305360 membrane palmitoylated protein 1 GO:0004385,GO:0005622,GO:0005829,GO:0005887,GO:0007165,GO:0016020,GO:0016607,GO:0030863,GO:0032420,GO:0090022 guanylate kinase activity|intracellular|cytosol|integral component of plasma membrane|signal transduction|membrane|nuclear speck|cortical cytoskeleton|stereocilium|regulation of neutrophil chemotaxis MPP2 209.50308738708 203.356963499525 215.649211274636 1.0604466528393 0.0846720460263825 0.733841696138394 1 1.12799 1.22588 1.24163 1.29132 GeneID:4355,Genbank:XM_011524827.2,HGNC:HGNC:7220,MIM:600723 membrane palmitoylated protein 2 GO:0004385,GO:0005737,GO:0005856,GO:0005887,GO:0007165,GO:0014069,GO:0016020,GO:0032590,GO:0032591,GO:0043197,GO:0043198,GO:0051260,GO:0060079,GO:0060291 guanylate kinase activity|cytoplasm|cytoskeleton|integral component of plasma membrane|signal transduction|postsynaptic density|membrane|dendrite membrane|dendritic spine membrane|dendritic spine|dendritic shaft|protein homooligomerization|excitatory postsynaptic potential|long-term synaptic potentiation MPP3 99.6599379676657 118.863785609866 80.4560903254654 0.676876391851914 -0.563035695568741 0.0677924616851334 0.916343630061028 0.696438 0.535581 0.559922 0.29589 GeneID:4356,Genbank:NM_001932.5,HGNC:HGNC:7221,MIM:601114 membrane palmitoylated protein 3 GO:0004385,GO:0005887,GO:0007165 guanylate kinase activity|integral component of plasma membrane|signal transduction MPP4 18.4303635551998 17.4788743361943 19.3818527742053 1.108873054489 0.149094212981983 0.857742236950701 1 0.123002 0.0674384 0.107938 0.127855 GeneID:58538,Genbank:NM_033066.2,HGNC:HGNC:13680,MIM:606575 membrane palmitoylated protein 4 GO:0005829,GO:0005913,GO:0015629,GO:0035418,GO:0043234 cytosol|cell-cell adherens junction|actin cytoskeleton|protein localization to synapse|protein complex hsa04530 Tight junction MPP5 389.901332941419 399.774458130784 380.028207752055 0.95060652331053 -0.0730797930625348 0.87278817598806 1 2.76205 2.12387 2.92182 1.81946 GeneID:64398,Genbank:NM_022474.3,HGNC:HGNC:18669,MIM:606958 membrane palmitoylated protein 5 GO:0002011,GO:0005737,GO:0005886,GO:0005913,GO:0005923,GO:0012505,GO:0019904,GO:0032287,GO:0032288,GO:0035749,GO:0035750,GO:0043219,GO:0043220,GO:0043234,GO:0070062,GO:0070830,GO:0072659,GO:0090162 morphogenesis of an epithelial sheet|cytoplasm|plasma membrane|cell-cell adherens junction|bicellular tight junction|endomembrane system|protein domain specific binding|peripheral nervous system myelin maintenance|myelin assembly|myelin sheath adaxonal region|protein localization to myelin sheath abaxonal region|lateral loop|Schmidt-Lanterman incisure|protein complex|extracellular exosome|bicellular tight junction assembly|protein localization to plasma membrane|establishment of epithelial cell polarity hsa04390,hsa04530,hsa05165 Hippo signaling pathway|Tight junction|Human papillomavirus infection MPP6 353.090480145003 362.039977180922 344.140983109085 0.950560724781806 -0.0731493012137502 0.827440030976303 1 1.69225 1.37963 1.80379 1.18124 GeneID:51678,Genbank:NM_016447.3,HGNC:HGNC:18167,MIM:606959 membrane palmitoylated protein 6 GO:0005886,GO:0006461,GO:0016020,GO:0030165,GO:0070062 plasma membrane|protein complex assembly|membrane|PDZ domain binding|extracellular exosome MPP7 26.0655674718282 31.2871174852624 20.844017458394 0.666217252778636 -0.585935379458276 0.298136446813344 1 0.169457 0.176651 0.14425 0.0914078 GeneID:143098,Genbank:NM_001318170.1,HGNC:HGNC:26542,MIM:610973 membrane palmitoylated protein 7 GO:0005654,GO:0005912,GO:0005923,GO:0019904,GO:0030010,GO:0030054,GO:0031334,GO:0032947,GO:0035591,GO:0045296,GO:0046982,GO:0070830,GO:0071896,GO:0097025 nucleoplasm|adherens junction|bicellular tight junction|protein domain specific binding|establishment of cell polarity|cell junction|positive regulation of protein complex assembly|protein complex scaffold activity|signaling adaptor activity|cadherin binding|protein heterodimerization activity|bicellular tight junction assembly|protein localization to adherens junction|MPP7-DLG1-LIN7 complex MPPE1 283.199479589195 259.646514138866 306.752445039524 1.18142331337236 0.240525986478066 0.237501851250249 1 1.65297 1.34806 1.55384 2.02103 GeneID:65258,Genbank:NM_001242904.1,HGNC:HGNC:15988,MIM:611900 metallophosphoesterase 1 GO:0005654,GO:0005783,GO:0005793,GO:0005794,GO:0005801,GO:0006506,GO:0006888,GO:0008081,GO:0016021,GO:0030145,GO:0033116,GO:0034235,GO:0070971 nucleoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|GPI anchor biosynthetic process|ER to Golgi vesicle-mediated transport|phosphoric diester hydrolase activity|integral component of membrane|manganese ion binding|endoplasmic reticulum-Golgi intermediate compartment membrane|GPI anchor binding|endoplasmic reticulum exit site MPPED2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.004687 0 0 GeneID:744,Genbank:NM_001145399.1,HGNC:HGNC:1180,MIM:600911 metallophosphoesterase domain containing 2 GO:0007399,GO:0016787,GO:0046872 nervous system development|hydrolase activity|metal ion binding MPRIP 6053.34890653303 5965.78334796661 6140.91446509945 1.02935592979462 0.0417419223299405 0.769941144404158 1 13.3343 14.2805 15.1545 13.5444 GeneID:23164,Genbank:XM_011523761.2,HGNC:HGNC:30321,MIM:612935 myosin phosphatase Rho interacting protein GO:0003779,GO:0005829,GO:0005925,GO:0015629,GO:0045296 actin binding|cytosol|focal adhesion|actin cytoskeleton|cadherin binding MPST 540.631437250765 525.953131152143 555.309743349388 1.05581602325085 0.078358465882618 0.797208881300213 1 10.3868 11.2687 10.3192 12.8393 GeneID:4357,Genbank:NM_001130517.2,HGNC:HGNC:7223,MIM:602496 mercaptopyruvate sulfurtransferase GO:0001822,GO:0001889,GO:0004792,GO:0005739,GO:0005829,GO:0009440,GO:0009636,GO:0016784,GO:0019346,GO:0021510,GO:0030054,GO:0042802,GO:0043005,GO:0045202,GO:0070062,GO:0070814 kidney development|liver development|thiosulfate sulfurtransferase activity|mitochondrion|cytosol|cyanate catabolic process|response to toxic substance|3-mercaptopyruvate sulfurtransferase activity|transsulfuration|spinal cord development|cell junction|identical protein binding|neuron projection|synapse|extracellular exosome|hydrogen sulfide biosynthetic process hsa00270,hsa00920,hsa04122 Cysteine and methionine metabolism|Sulfur metabolism|Sulfur relay system MPV17 942.38717902183 953.373501546386 931.400856497275 0.976952742011949 -0.0336393182760768 0.821058930844969 1 6.91177 7.34171 6.73101 7.29973 GeneID:4358,Genbank:NM_002437.4,HGNC:HGNC:7224,MIM:137960 MPV17, mitochondrial inner membrane protein GO:0000002,GO:0005739,GO:0005743,GO:0005777,GO:0016021,GO:0032836,GO:0034614,GO:0042592,GO:0048839,GO:2000377 mitochondrial genome maintenance|mitochondrion|mitochondrial inner membrane|peroxisome|integral component of membrane|glomerular basement membrane development|cellular response to reactive oxygen species|homeostatic process|inner ear development|regulation of reactive oxygen species metabolic process hsa04146 Peroxisome MPV17L 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:255027,Genbank:XM_017023108.1,HGNC:HGNC:26827 MPV17 mitochondrial inner membrane protein like GO:0005102,GO:0005737,GO:0005739,GO:0005777,GO:0005778,GO:0010730,GO:0016021,GO:0043231,GO:0072593,GO:1901029 receptor binding|cytoplasm|mitochondrion|peroxisome|peroxisomal membrane|negative regulation of hydrogen peroxide biosynthetic process|integral component of membrane|intracellular membrane-bounded organelle|reactive oxygen species metabolic process|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway hsa04146 Peroxisome MPV17L2 627.232504520051 666.119292763637 588.345716276466 0.883243771300334 -0.179116424726493 0.286131675366847 1 24.4304 22.154 21.7986 20.2482 GeneID:84769,Genbank:NM_032683.2,HGNC:HGNC:28177,MIM:616133 MPV17 mitochondrial inner membrane protein like 2 GO:0005743,GO:0005762,GO:0016021,GO:0061668,GO:0070131 mitochondrial inner membrane|mitochondrial large ribosomal subunit|integral component of membrane|mitochondrial ribosome assembly|positive regulation of mitochondrial translation hsa04146 Peroxisome MPZ 10.2093977138443 11.2138073152264 9.20498811246207 0.820861983241254 -0.284788422009487 0.791671574955798 1 0.135613 0.139153 0.0479655 0.134248 GeneID:4359,Genbank:XM_017001321.2,HGNC:HGNC:7225,MIM:159440 myelin protein zero hsa04514 Cell adhesion molecules (CAMs) MPZL1 2507.19565606913 2497.16497723666 2517.2263349016 1.00803365330197 0.0115438041566828 0.931336495816435 1 22.0182 21.8883 23.605 21.2429 GeneID:9019,Genbank:NM_003953.5,HGNC:HGNC:7226,MIM:604376 myelin protein zero like 1 GO:0005198,GO:0005887,GO:0005925,GO:0007169,GO:0007267,GO:0009986 structural molecule activity|integral component of plasma membrane|focal adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|cell-cell signaling|cell surface hsa04514 Cell adhesion molecules (CAMs) MPZL3 15.6953320970529 18.3051296609463 13.0855345331594 0.714856151009802 -0.484275134260431 0.561521907104898 1 0.236022 0.0821309 0.124101 0.125171 GeneID:196264,Genbank:NM_001286152.1,HGNC:HGNC:27279,MIM:611707 myelin protein zero like 3 GO:0007155,GO:0016021,GO:0030198,GO:0042633 cell adhesion|integral component of membrane|extracellular matrix organization|hair cycle MR1 530.717739034108 475.523803025219 585.911675042996 1.23213952974699 0.301165638724282 0.0801397628787025 0.950050660448038 2.01533 2.12466 2.60092 2.51995 GeneID:3140,Genbank:XM_011509463.2,HGNC:HGNC:4975,MIM:600764 major histocompatibility complex, class I-related GO:0002367,GO:0002474,GO:0005576,GO:0005783,GO:0005789,GO:0005886,GO:0006955,GO:0016021,GO:0032393,GO:0032611,GO:0032620,GO:0042612,GO:0045087,GO:0050829 cytokine production involved in immune response|antigen processing and presentation of peptide antigen via MHC class I|extracellular region|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|immune response|integral component of membrane|MHC class I receptor activity|interleukin-1 beta production|interleukin-17 production|MHC class I protein complex|innate immune response|defense response to Gram-negative bacterium MRAP 5.82094242384226 6.31309329565283 5.32879155203169 0.844085664899183 -0.244538671720746 0.942253107410887 1 0.061899 0 0 0 GeneID:56246,Genbank:NM_206898.1,HGNC:HGNC:1304,MIM:609196 melanocortin 2 receptor accessory protein GO:0005783,GO:0005789,GO:0005886,GO:0016021,GO:0031780,GO:0031781,GO:0031782,GO:0031783,GO:0042802,GO:0070996,GO:0072659,GO:0106071,GO:0106072,GO:1903077 endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of membrane|corticotropin hormone receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding|identical protein binding|type 1 melanocortin receptor binding|protein localization to plasma membrane|positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway|negative regulation of protein localization to plasma membrane hsa04927,hsa04934 Cortisol synthesis and secretion|Cushing syndrome MRAP2 171.936690595366 134.027590106075 209.845791084657 1.56569099629842 0.646799511418104 0.00821486362839549 0.355592583438871 0.882196 1.209 1.64627 1.63986 GeneID:112609,Genbank:XM_017010220.1,HGNC:HGNC:21232,MIM:615410 melanocortin 2 receptor accessory protein 2 GO:0005783,GO:0005789,GO:0005886,GO:0006112,GO:0007631,GO:0016021,GO:0030819,GO:0031780,GO:0031781,GO:0031782,GO:0031783,GO:0042802,GO:0070996,GO:0072659,GO:0097009,GO:0106071,GO:0106072,GO:1903077 endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|energy reserve metabolic process|feeding behavior|integral component of membrane|positive regulation of cAMP biosynthetic process|corticotropin hormone receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding|identical protein binding|type 1 melanocortin receptor binding|protein localization to plasma membrane|energy homeostasis|positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway|negative regulation of protein localization to plasma membrane MRAS 860.067454299304 733.950042986746 986.184865611863 1.34366756298381 0.426176244843325 0.00649004485241997 0.318458466834409 4.4916 4.49252 5.84697 6.12885 GeneID:22808,Genbank:NM_012219.4,HGNC:HGNC:7227,MIM:608435 muscle RAS oncogene homolog GO:0003924,GO:0005525,GO:0005622,GO:0005886,GO:0007265,GO:0007275,GO:0007517,GO:0030036,GO:0030742,GO:0070062,GO:1990830 GTPase activity|GTP binding|intracellular|plasma membrane|Ras protein signal transduction|multicellular organism development|muscle organ development|actin cytoskeleton organization|GTP-dependent protein binding|extracellular exosome|cellular response to leukemia inhibitory factor hsa04010,hsa04014,hsa04015,hsa04072,hsa04137,hsa04140,hsa04218,hsa04371,hsa04625,hsa04810,hsa05166,hsa05205 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Cellular senescence|Apelin signaling pathway|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Human T-cell leukemia virus 1 infection|Proteoglycans in cancer MRC1 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.00704429 0.00668122 0 0 GeneID:4360,Genbank:NM_002438.3,HGNC:HGNC:7228,MIM:153618 mannose receptor C-type 1 hsa04145,hsa05152 Phagosome|Tuberculosis MRC2 4153.02864017413 3816.5795304222 4489.47774992606 1.17630923557079 0.234267374781617 0.0840744035315667 0.963274948662815 25.0298 25.4541 29.9085 30.6528 GeneID:9902,Genbank:NM_006039.4,HGNC:HGNC:16875,MIM:612264 mannose receptor C type 2 hsa04145,hsa05152 Phagosome|Tuberculosis MRE11 196.356333142275 227.417471469266 165.295194815283 0.726835953928113 -0.46029830867961 0.145646764831172 1 1.45711 1.40081 1.30404 0.745124 GeneID:4361,Genbank:NM_001330347.1,HGNC:HGNC:7230,MIM:600814 MRE11 homolog, double strand break repair nuclease GO:0000781,GO:0004519,GO:0006302,GO:0008408,GO:0030145,GO:0030870,GO:0051321 chromosome, telomeric region|endonuclease activity|double-strand break repair|3'-5' exonuclease activity|manganese ion binding|Mre11 complex|meiotic cell cycle hsa03440,hsa03450,hsa04218 Homologous recombination|Non-homologous end-joining|Cellular senescence MREG 270.98418353157 273.944828689892 268.023538373249 0.978385099127585 -0.0315256631995371 0.887680035402218 1 3.41173 3.46275 3.78894 2.87895 GeneID:55686,Genbank:NM_018000.2,HGNC:HGNC:25478,MIM:609207 melanoregulin GO:0016324,GO:0030318,GO:0032402,GO:0042470,GO:0043234 apical plasma membrane|melanocyte differentiation|melanosome transport|melanosome|protein complex MRFAP1 10936.2391489476 10446.3929946739 11426.0853032212 1.09378283097781 0.129326321519151 0.311482293392817 1 244.816 229.034 269.862 255.244 GeneID:93621,Genbank:NM_033296.2,HGNC:HGNC:24549,MIM:616905 Morf4 family associated protein 1 GO:0005634,GO:0005829,GO:0048471 nucleus|cytosol|perinuclear region of cytoplasm MRFAP1L1 1326.44155928524 1293.0524906809 1359.83062788959 1.05164379457907 0.0726461278088518 0.608883562679816 1 31.5304 29.9759 32.9652 32.4704 GeneID:114932,Genbank:NM_203462.2,HGNC:HGNC:28796 Morf4 family associated protein 1 like 1 GO:0042802 identical protein binding MRGBP 1295.37590224944 1306.52658390888 1284.22522058999 0.982930800189178 -0.0248382426532063 0.850382371761083 1 17.0876 18.0561 17.3312 17.6797 GeneID:55257,Genbank:NM_018270.5,HGNC:HGNC:15866,MIM:611157 MRG domain binding protein GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0016573,GO:0035267,GO:0040008 nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|histone acetylation|NuA4 histone acetyltransferase complex|regulation of growth MRGPRF 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:116535,Genbank:XM_024448339.1,HGNC:HGNC:24828,MIM:607233 MAS related GPR family member F GO:0004930,GO:0005886,GO:0005887,GO:0031965,GO:0070062 G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|nuclear membrane|extracellular exosome MRGPRX4 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0350328 GeneID:117196,Genbank:NM_054032.3,HGNC:HGNC:17617,MIM:607230 MAS related GPR family member X4 GO:0004930,GO:0005887 G-protein coupled receptor activity|integral component of plasma membrane MRI1 655.451288577689 674.153557294549 636.749019860828 0.944516294501464 -0.0823524091327125 0.616521775362991 1 6.61054 7.28924 6.54029 7.13832 GeneID:84245,Genbank:XM_011528357.3,HGNC:HGNC:28469,MIM:615105 methylthioribose-1-phosphate isomerase 1 GO:0001650,GO:0005654,GO:0005829,GO:0019509,GO:0042802,GO:0042995,GO:0046523 fibrillar center|nucleoplasm|cytosol|L-methionine salvage from methylthioadenosine|identical protein binding|cell projection|S-methyl-5-thioribose-1-phosphate isomerase activity hsa00270 Cysteine and methionine metabolism MRM1 228.609836300436 238.170633347859 219.049039253013 0.919714727940794 -0.120741651550671 0.568666595525587 1 1.58754 1.93752 1.74069 1.64321 GeneID:79922,Genbank:XM_011525275.3,HGNC:HGNC:26202 mitochondrial rRNA methyltransferase 1 GO:0000451,GO:0000453,GO:0003723,GO:0005739,GO:0005759,GO:0070039 rRNA 2'-O-methylation|enzyme-directed rRNA 2'-O-methylation|RNA binding|mitochondrion|mitochondrial matrix|rRNA (guanosine-2'-O-)-methyltransferase activity MRM2 1447.42822779601 1528.22791168979 1366.62854390223 0.894257023738776 -0.161238550301689 0.251997184768177 1 28.0731 33.385 27.9307 27.7562 GeneID:29960,Genbank:NM_013393.1,HGNC:HGNC:16352,MIM:606906 mitochondrial rRNA methyltransferase 2 GO:0000451,GO:0005730,GO:0005739,GO:0005759,GO:0006364,GO:0008283,GO:0008650,GO:0031167 rRNA 2'-O-methylation|nucleolus|mitochondrion|mitochondrial matrix|rRNA processing|cell proliferation|rRNA (uridine-2'-O-)-methyltransferase activity|rRNA methylation MRM3 722.751864611736 763.220056935241 682.283672288231 0.893954064870864 -0.161727393328437 0.408099863955593 1 17.7614 19.8458 15.2468 18.6665 GeneID:55178,Genbank:NM_018146.3,HGNC:HGNC:18485,MIM:612600 mitochondrial rRNA methyltransferase 3 GO:0000451,GO:0003723,GO:0005739,GO:0005759,GO:0070039 rRNA 2'-O-methylation|RNA binding|mitochondrion|mitochondrial matrix|rRNA (guanosine-2'-O-)-methyltransferase activity MRNIP 230.921614484872 252.53557448293 209.307654486813 0.828824433608504 -0.270861560822561 0.496159065556369 1 4.97277 4.52647 3.50581 5.31085 GeneID:51149,Genbank:NM_001017987.2,HGNC:HGNC:30817,MIM:617154 MRN complex interacting protein GO:0003682,GO:0005634,GO:0005654,GO:0006281,GO:0006974,GO:0007095,GO:0010212,GO:0045860,GO:0071168,GO:1905168,GO:2001032 chromatin binding|nucleus|nucleoplasm|DNA repair|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|response to ionizing radiation|positive regulation of protein kinase activity|protein localization to chromatin|positive regulation of double-strand break repair via homologous recombination|regulation of double-strand break repair via nonhomologous end joining MRO 3.42862748213965 2.00831188251439 4.84894308176491 2.41443728137189 1.27168698783073 0.512531225080143 1 0 0.0227658 0.061406 0.0143202 GeneID:83876,Genbank:NM_001127174.1,HGNC:HGNC:24121,MIM:608080 maestro GO:0005730 nucleolus MROH1 581.706053276869 531.438952122189 631.973154431549 1.18917356717625 0.249959300642446 0.138508013873947 1 2.41186 2.22854 3.15716 2.79697 GeneID:727957,Genbank:NM_032450.2,HGNC:HGNC:26958 maestro heat like repeat family member 1 MROH2A 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:339766,Genbank:XM_024452842.1,HGNC:HGNC:27936 maestro heat like repeat family member 2A MROH2B 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:133558,Genbank:NM_173489.4,HGNC:HGNC:26857 maestro heat like repeat family member 2B GO:0001669,GO:0005737,GO:0007283,GO:0010737,GO:0030154,GO:0036126,GO:0097225 acrosomal vesicle|cytoplasm|spermatogenesis|protein kinase A signaling|cell differentiation|sperm flagellum|sperm midpiece MROH5 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00940396 GeneID:389690,Genbank:NM_207414.2,HGNC:HGNC:42976 maestro heat like repeat family member 5 MROH6 28.7989673523434 29.9707907585531 27.6271439461338 0.921802303072351 -0.117470722714093 0.833047964279667 1 0.329289 0.355461 0.329508 0.196486 GeneID:642475,Genbank:XM_011517215.1,HGNC:HGNC:27814 maestro heat like repeat family member 6 MROH8 72.4455407532444 66.3987536368138 78.492327869675 1.18213556084216 0.241395485380648 0.595611396499257 1 0.0982598 0.100479 0.20724 0.221878 GeneID:140699,Genbank:NM_152503.5,HGNC:HGNC:16125 maestro heat like repeat family member 8 MRPL1 223.23261923469 266.670192899685 179.795045569695 0.674222505390129 -0.568703309937188 0.0107445864680911 0.413666579021508 7.86591 7.06035 5.16254 4.97324 GeneID:65008,Genbank:NM_020236.3,HGNC:HGNC:14275,MIM:611821 mitochondrial ribosomal protein L1 GO:0000469,GO:0000470,GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0006412,GO:0015934,GO:0031118,GO:0031120,GO:0031429,GO:0034513,GO:0070125,GO:0070126 cleavage involved in rRNA processing|maturation of LSU-rRNA|RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|translation|large ribosomal subunit|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis|box H/ACA snoRNP complex|box H/ACA snoRNA binding|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL10 808.612410188201 743.973002089957 873.251818286445 1.17376815534075 0.231147473037721 0.150330548763047 1 14.7107 16.3784 17.511 18.6674 GeneID:124995,Genbank:NM_145255.3,HGNC:HGNC:14055,MIM:611825 mitochondrial ribosomal protein L10 GO:0003723,GO:0003735,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0030529,GO:0032543,GO:0042254,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|intracellular ribonucleoprotein complex|mitochondrial translation|ribosome biogenesis|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL11 1124.14003976137 1176.85281849149 1071.42726103125 0.910417381168042 -0.135399993871194 0.44887808538229 1 10.8228 12.886 10.2325 12.2458 GeneID:65003,Genbank:NM_170738.3,HGNC:HGNC:14042,MIM:611826 mitochondrial ribosomal protein L11 GO:0000027,GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0019843,GO:0070125,GO:0070126 ribosomal large subunit assembly|RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|rRNA binding|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL12 2940.67769422421 3064.92232438265 2816.43306406576 0.918924777199063 -0.121981326956948 0.517093368130715 1 122.477 141.243 114.642 131.606 GeneID:6182,Genbank:NM_002949.3,HGNC:HGNC:10378,MIM:602375 mitochondrial ribosomal protein L12 GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006390,GO:0045893,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|transcription from mitochondrial promoter|positive regulation of transcription, DNA-templated|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL13 1283.9457506965 1356.35692842681 1211.53457296619 0.89322695787119 -0.16290130207876 0.278438206013408 1 45.7054 42.0734 39.1384 39.6519 GeneID:28998,Genbank:NM_014078.5,HGNC:HGNC:14278,MIM:610200 mitochondrial ribosomal protein L13 GO:0003723,GO:0003729,GO:0003735,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126 RNA binding|mRNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL14 1388.52137087147 1504.11937744536 1272.92336429757 0.846291446932583 -0.240773508805527 0.391179542674717 1 30.3227 37.1786 25.4903 32.2574 GeneID:64928,Genbank:NM_001318767.1,HGNC:HGNC:14279,MIM:611827 mitochondrial ribosomal protein L14 GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL15 1511.43144525069 1498.79420160702 1524.06868889436 1.01686321394908 0.0241256242990216 0.883548371643251 1 21.2667 24.7832 21.9684 24.5718 GeneID:29088,Genbank:NM_014175.3,HGNC:HGNC:14054,MIM:611828 mitochondrial ribosomal protein L15 GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126,GO:1990830 RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination|cellular response to leukemia inhibitory factor hsa03010 Ribosome MRPL16 1225.14099539573 1309.48561262999 1140.79637816148 0.871179008886008 -0.198958902243127 0.176023269383115 1 45.8469 47.4491 41.2582 40.1409 GeneID:54948,Genbank:NM_017840.3,HGNC:HGNC:14476,MIM:611829 mitochondrial ribosomal protein L16 GO:0003735,GO:0005743,GO:0005762,GO:0019843,GO:0032543,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|rRNA binding|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL17 1338.93695553643 1411.66059561054 1266.21331546232 0.896967245100921 -0.156872792232543 0.447104431835131 1 21.6976 26.7974 19.9088 24.0271 GeneID:63875,Genbank:NM_022061.3,HGNC:HGNC:14053,MIM:611830 mitochondrial ribosomal protein L17 GO:0000002,GO:0003735,GO:0005743,GO:0005762,GO:0019904,GO:0070125,GO:0070126 mitochondrial genome maintenance|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|protein domain specific binding|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL18 2862.94181227573 2966.58944337689 2759.29418117456 0.930123373604956 -0.104506003738736 0.434764995228782 1 109.231 116.294 100.285 110.603 GeneID:29074,Genbank:NM_014161.4,HGNC:HGNC:14477,MIM:611831 mitochondrial ribosomal protein L18 GO:0003735,GO:0005615,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0008097,GO:0035928,GO:0070125,GO:0070126 structural constituent of ribosome|extracellular space|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|5S rRNA binding|rRNA import into mitochondrion|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL19 807.787975812009 883.773553813333 731.802397810686 0.828042878917436 -0.27222261750114 0.0900658600821877 0.979717040875575 6.41771 6.09867 5.43496 5.05155 GeneID:9801,Genbank:NM_014763.3,HGNC:HGNC:14052,MIM:611832 mitochondrial ribosomal protein L19 GO:0003735,GO:0005634,GO:0005739,GO:0005743,GO:0005762,GO:0031965,GO:0070125,GO:0070126 structural constituent of ribosome|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|nuclear membrane|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL2 995.993383560466 1032.95615676136 959.030610359569 0.928433026011893 -0.107130252066951 0.472061961530291 1 22.7529 24.1124 22.0645 22.6686 GeneID:51069,Genbank:NM_001300848.1,HGNC:HGNC:14056,MIM:611822 mitochondrial ribosomal protein L2 GO:0003723,GO:0003735,GO:0005743,GO:0005762,GO:0032543,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL20 1892.82615425517 2011.13998636309 1774.51232214726 0.882341524796717 -0.180590912164296 0.330624987799776 1 55.4296 52.5471 43.9473 53.4603 GeneID:55052,Genbank:NM_017971.3,HGNC:HGNC:14478,MIM:611833 mitochondrial ribosomal protein L20 GO:0000027,GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0019843,GO:0070125,GO:0070126 ribosomal large subunit assembly|RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|rRNA binding|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL21 738.351347091251 746.423359099743 730.279335082759 0.978371491432884 -0.0315457288058142 0.829793147185243 1 12.5326 13.3223 12.2416 14.5981 GeneID:219927,Genbank:NM_181514.1,HGNC:HGNC:14479,MIM:611834 mitochondrial ribosomal protein L21 GO:0003723,GO:0003735,GO:0005743,GO:0005762,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL22 1077.33250510794 1067.72078333416 1086.94422688172 1.01800418597035 0.0257434936987301 0.865348903364301 1 13.5334 13.6638 12.9163 14.9337 GeneID:29093,Genbank:NM_014180.3,HGNC:HGNC:14480,MIM:611835 mitochondrial ribosomal protein L22 GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL23 715.049452027568 731.288980568858 698.809923486278 0.95558656297909 -0.065541527467883 0.672738397655494 1 4.79175 5.23707 5.03242 5.23094 GeneID:6150,Genbank:XM_011520275.2,HGNC:HGNC:10322,MIM:600789 mitochondrial ribosomal protein L23 GO:0001650,GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0032543,GO:0070125,GO:0070126 fibrillar center|RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL24 1454.64977085546 1457.03227123617 1452.26727047476 0.996729653244149 -0.00472584484120372 0.982283199169907 1 37.0622 36.2598 32.5139 39.7494 GeneID:79590,Genbank:NM_024540.3,HGNC:HGNC:14037,MIM:611836 mitochondrial ribosomal protein L24 GO:0003735,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL27 1340.98448442801 1380.84291521617 1301.12605363984 0.942269420585146 -0.085788470115111 0.554718440960211 1 80.4096 84.3739 75.0027 83.4125 GeneID:51264,Genbank:NM_016504.2,HGNC:HGNC:14483,MIM:611837 mitochondrial ribosomal protein L27 GO:0003723,GO:0003735,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL28 1895.86478041439 1870.81012861732 1920.91943221146 1.02678481521327 0.0381338656359258 0.835808472659199 1 46.4658 49.0323 47.4869 53.5902 GeneID:10573,Genbank:NM_006428.4,HGNC:HGNC:14484,MIM:604853 mitochondrial ribosomal protein L28 GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0005829,GO:0006412,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|cytosol|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL3 2072.97824061031 2164.26953548954 1981.68694573108 0.915637776735067 -0.127151109075394 0.360849098402624 1 41.6404 44.8802 42.4935 38.7418 GeneID:11222,Genbank:NM_007208.3,HGNC:HGNC:10379,MIM:607118 mitochondrial ribosomal protein L3 GO:0003723,GO:0003735,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL30 1111.14908653271 1161.97615464253 1060.32201842289 0.91251615980802 -0.132077987000814 0.381294827692735 1 10.2029 10.6368 9.26605 9.81135 GeneID:51263,Genbank:NM_145212.3,HGNC:HGNC:14036,MIM:611838 mitochondrial ribosomal protein L30 GO:0003735,GO:0005743,GO:0005762,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL32 985.936395456284 1048.20518815098 923.667602761589 0.881189688052323 -0.182475482602564 0.230644806565415 1 41.7199 43.9224 37.6117 39.0497 GeneID:64983,Genbank:NM_031903.2,HGNC:HGNC:14035,MIM:611839 mitochondrial ribosomal protein L32 GO:0003723,GO:0003735,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL33 1916.35213713708 2162.92581679921 1669.77845747494 0.771999873738594 -0.373327483348307 0.117908049607015 1 144.678 164.822 101.036 131.36 GeneID:9553,Genbank:NM_004891.3,HGNC:HGNC:14487,MIM:610059 mitochondrial ribosomal protein L33 GO:0003735,GO:0005743,GO:0005762,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL34 1643.39388042835 1690.06409319274 1596.72366766397 0.944771073532225 -0.0819633010990189 0.634355614406875 1 89.269 98.2248 83.2876 95.0273 GeneID:64981,Genbank:XM_011528189.2,HGNC:HGNC:14488,MIM:611840 mitochondrial ribosomal protein L34 GO:0003735,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL35 918.275706422341 1000.08213820979 836.469274634893 0.836400574189063 -0.257734042549266 0.0984067274622481 1 11.4893 11.4972 9.7455 9.38692 GeneID:51318,Genbank:NM_016622.3,HGNC:HGNC:14489,MIM:611841 mitochondrial ribosomal protein L35 GO:0003735,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL36 1190.10125344676 1143.98860859502 1236.2138982985 1.08061731472724 0.11185570356049 0.461035913172539 1 41.6095 40.4967 44.1229 46.1144 GeneID:64979,Genbank:XM_011514080.2,HGNC:HGNC:14490,MIM:611842 mitochondrial ribosomal protein L36 GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0016604,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|nuclear body|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL37 4158.67985854747 4080.80140031381 4236.55831678113 1.03816821775628 0.0540402271833109 0.709235214199258 1 79.255 87.0277 86.9412 86.8027 GeneID:51253,Genbank:NM_001330602.1,HGNC:HGNC:14034,MIM:611843 mitochondrial ribosomal protein L37 MRPL38 1547.7058675686 1586.34449476887 1509.06724036834 0.951285956704012 -0.0720490142573294 0.659577271019252 1 38.0051 45.097 39.4113 41.7153 GeneID:64978,Genbank:NM_032478.3,HGNC:HGNC:14033,MIM:611844 mitochondrial ribosomal protein L38 GO:0005743,GO:0005762,GO:0070125,GO:0070126 mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL39 371.692054146854 397.843598488278 345.540509805429 0.868533542121604 -0.203346529062721 0.292921667233249 1 4.18409 4.01593 3.99222 3.43669 GeneID:54148,Genbank:XM_011529651.2,HGNC:HGNC:14027,MIM:611845 mitochondrial ribosomal protein L39 GO:0000166,GO:0003723,GO:0005743,GO:0005761,GO:0005762,GO:0070125,GO:0070126 nucleotide binding|RNA binding|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL4 1903.28568886441 1876.39301913759 1930.17835859123 1.02866421847932 0.0407721276243572 0.796113805971384 1 29.4145 30.7881 29.9878 32.068 GeneID:51073,Genbank:XM_011528045.3,HGNC:HGNC:14276,MIM:611823 mitochondrial ribosomal protein L4 GO:0003723,GO:0003735,GO:0005743,GO:0005762,GO:0006412,GO:0022626,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|cytosolic ribosome|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPL40 620.727769423325 608.119396544999 633.33614230165 1.04146676771029 0.0586168049815509 0.781619541303789 1 13.0683 12.8978 11.8316 15.7405 GeneID:64976,Genbank:NM_003776.3,HGNC:HGNC:14491,MIM:605089 mitochondrial ribosomal protein L40 GO:0003723,GO:0005634,GO:0005743,GO:0005761,GO:0005762,GO:0009653,GO:0070125,GO:0070126 RNA binding|nucleus|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|anatomical structure morphogenesis|mitochondrial translational elongation|mitochondrial translational termination MRPL41 1793.24783403873 1740.17583770623 1846.31983037123 1.06099613060075 0.0854193948263927 0.652904114269364 1 203.443 224.333 224.088 242.465 GeneID:64975,Genbank:NM_032477.2,HGNC:HGNC:14492,MIM:611846 mitochondrial ribosomal protein L41 GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0006412,GO:0006915,GO:0007049,GO:0030529,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|apoptotic process|cell cycle|intracellular ribonucleoprotein complex|mitochondrial translational elongation|mitochondrial translational termination MRPL42 762.335423050738 832.586630947413 692.084215154062 0.831245890132212 -0.266652792379297 0.0974596142150357 1 12.3032 12.4154 11.1114 9.40779 GeneID:28977,Genbank:NM_172177.3,HGNC:HGNC:14493,MIM:611847 mitochondrial ribosomal protein L42 GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0005763,GO:0005886,GO:0006412,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial small ribosomal subunit|plasma membrane|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL43 1684.82936298384 1712.34762899914 1657.31109696854 0.967859019337815 -0.0471311784977891 0.766224286886815 1 20.9849 24.4183 21.2667 23.4984 GeneID:84545,Genbank:NM_176792.2,HGNC:HGNC:14517,MIM:611848 mitochondrial ribosomal protein L43 GO:0003723,GO:0003735,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL44 825.768140857463 835.931903867707 815.604377847218 0.975682796736866 -0.0355159040213729 0.805777047525261 1 17.2814 19.7882 17.4963 18.0403 GeneID:65080,Genbank:XM_011511668.2,HGNC:HGNC:16650,MIM:611849 mitochondrial ribosomal protein L44 GO:0003723,GO:0003725,GO:0004525,GO:0005634,GO:0005739,GO:0005743,GO:0005762,GO:0005886,GO:0006396,GO:0070125,GO:0070126,GO:0090502 RNA binding|double-stranded RNA binding|ribonuclease III activity|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|plasma membrane|RNA processing|mitochondrial translational elongation|mitochondrial translational termination|RNA phosphodiester bond hydrolysis, endonucleolytic MRPL45 1295.99009708939 1340.22584078436 1251.75435339441 0.933987627534353 -0.0985246561013108 0.487175656837759 1 26.7448 30.3187 26.4029 27.2573 GeneID:84311,Genbank:NM_032351.5,HGNC:HGNC:16651,MIM:611850 mitochondrial ribosomal protein L45 GO:0003723,GO:0005743,GO:0005762,GO:0070125,GO:0070126 RNA binding|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL46 660.80824440352 690.67088913619 630.94559967085 0.913525688711107 -0.13048279629729 0.426652595228092 1 22.3532 22.1038 19.501 20.6866 GeneID:26589,Genbank:NM_022163.3,HGNC:HGNC:1192,MIM:611851 mitochondrial ribosomal protein L46 GO:0003735,GO:0005654,GO:0005739,GO:0005743,GO:0005762,GO:0016787,GO:0030054,GO:0070125,GO:0070126 structural constituent of ribosome|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|hydrolase activity|cell junction|mitochondrial translational elongation|mitochondrial translational termination MRPL47 1246.06479621924 1277.65938046723 1214.47021197126 0.950543024641777 -0.0731761655069277 0.627850630465717 1 36.388 36.3005 37.1224 35.1446 GeneID:57129,Genbank:NM_177988.1,HGNC:HGNC:16652,MIM:611852 mitochondrial ribosomal protein L47 GO:0003735,GO:0005739,GO:0005743,GO:0005762,GO:0032543,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPL48 399.25000997469 428.766123086277 369.733896863103 0.862320684763393 -0.213703608078044 0.247504153533231 1 9.62757 8.79537 7.55108 8.55233 GeneID:51642,Genbank:NM_001318499.1,HGNC:HGNC:16653,MIM:611853 mitochondrial ribosomal protein L48 GO:0005743,GO:0005761,GO:0005762,GO:0070125,GO:0070126 mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL49 1855.30229637748 1826.95364246969 1883.65095028526 1.03103379664244 0.0440916241214493 0.77100085191559 1 33.263 35.3186 34.7176 37.2064 GeneID:740,Genbank:NM_004927.3,HGNC:HGNC:1176,MIM:606866 mitochondrial ribosomal protein L49 GO:0003735,GO:0005743,GO:0005761,GO:0005762,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL50 281.626606655673 298.159224138795 265.093989172551 0.889102089456565 -0.169579011606682 0.424901403016472 1 12.8096 10.9297 11.1935 10.4167 GeneID:54534,Genbank:NM_019051.2,HGNC:HGNC:16654,MIM:611854 mitochondrial ribosomal protein L50 GO:0005743,GO:0005762,GO:0070125,GO:0070126 mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL51 2252.29303674171 2421.83130250674 2082.75477097668 0.859991680188833 -0.217605392059105 0.131984647726469 1 147.893 153.815 121.148 137.33 GeneID:51258,Genbank:NM_016497.3,HGNC:HGNC:14044,MIM:611855 mitochondrial ribosomal protein L51 GO:0003735,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0032543,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPL52 1187.8618791831 1241.34810444941 1134.3756539168 0.91382558192244 -0.130009264514295 0.537078306982209 1 9.41055 11.7101 8.8119 11.8611 GeneID:122704,Genbank:XM_005267325.5,HGNC:HGNC:16655,MIM:611856 mitochondrial ribosomal protein L52 GO:0003735,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL53 733.047549785624 693.688769787943 772.406329783304 1.11347676857941 0.155071458256002 0.515294227673877 1 67.5947 71.2097 68.9028 86.285 GeneID:116540,Genbank:NM_053050.4,HGNC:HGNC:16684,MIM:611857 mitochondrial ribosomal protein L53 GO:0005743,GO:0005762,GO:0070125,GO:0070126 mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL54 905.651844002402 1021.48361776335 789.820070241452 0.773208749026096 -0.37107013283595 0.164746454137409 1 64.8901 72.9306 46.4917 60.544 GeneID:116541,Genbank:NM_172251.2,HGNC:HGNC:16685,MIM:611858 mitochondrial ribosomal protein L54 GO:0003723,GO:0005743,GO:0005762,GO:0070125,GO:0070126 RNA binding|mitochondrial inner membrane|mitochondrial large ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPL55 637.550813457477 638.311718367616 636.789908547338 0.997615882998092 -0.00344366045336856 0.968022116635523 1 10.0323 11.7026 10.0379 10.5759 GeneID:128308,Genbank:NM_181465.2,HGNC:HGNC:16686,MIM:611859 mitochondrial ribosomal protein L55 GO:0003735,GO:0005743,GO:0005762,GO:0006412,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPL57 1082.82163894169 1062.67700749138 1102.966270392 1.03791299013397 0.053685505387782 0.739620167623896 1 15.814 17.0428 16.8471 17.9011 GeneID:78988,Genbank:NM_024026.4,HGNC:HGNC:14514,MIM:611997 mitochondrial ribosomal protein L57 GO:0003735,GO:0005743,GO:0005761,GO:0032543,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPL58 897.026181239399 915.466532808 878.585829670797 0.959713761436938 -0.059323914607812 0.680630002047855 1 21.7189 24.1402 21.3891 23.5736 GeneID:3396,Genbank:NM_001545.2,HGNC:HGNC:5359,MIM:603000 mitochondrial ribosomal protein L58 GO:0004045,GO:0005739,GO:0005743,GO:0005759,GO:0005762,GO:0016150,GO:0070125,GO:0070126,GO:0072344 aminoacyl-tRNA hydrolase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial large ribosomal subunit|translation release factor activity, codon nonspecific|mitochondrial translational elongation|mitochondrial translational termination|rescue of stalled ribosome MRPL9 1408.49499095133 1372.80966768611 1444.18031421655 1.05198874120018 0.0731192644195814 0.630228866229367 1 30.4356 33.1197 35.0436 33.7886 GeneID:65005,Genbank:NM_001300733.1,HGNC:HGNC:14277,MIM:611824 mitochondrial ribosomal protein L9 GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005762,GO:0006412,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial large ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS10 1597.08226227661 1648.25210254549 1545.91242200774 0.937910177466358 -0.0924783307062198 0.525872600347493 1 27.5049 26.8502 24.9781 25.8645 GeneID:55173,Genbank:NM_018141.3,HGNC:HGNC:14502,MIM:611976 mitochondrial ribosomal protein S10 GO:0005743,GO:0005763,GO:0070125,GO:0070126 mitochondrial inner membrane|mitochondrial small ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS11 1312.26950135591 1282.67678134724 1341.86222136458 1.04614213095459 0.0650788723241949 0.675504773061487 1 4.81602 5.86396 5.4951 6.23658 GeneID:64963,Genbank:NM_001321972.1,HGNC:HGNC:14050,MIM:611977 mitochondrial ribosomal protein S11 GO:0000028,GO:0000462,GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0032543,GO:0042769,GO:0048027,GO:0070125,GO:0070126,GO:0070181 ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translation|DNA damage response, detection of DNA damage|mRNA 5'-UTR binding|mitochondrial translational elongation|mitochondrial translational termination|small ribosomal subunit rRNA binding hsa03010 Ribosome MRPS12 1317.70128928417 1381.76624009115 1253.63633847718 0.907270927674779 -0.140394664698982 0.405499896663102 1 42.6202 48.4195 40.9013 47.3013 GeneID:6183,Genbank:NM_033362.3,HGNC:HGNC:10380,MIM:603021 mitochondrial ribosomal protein S12 GO:0003723,GO:0003735,GO:0005743,GO:0005761,GO:0005763,GO:0006412,GO:0032543,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial small ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS14 656.228102853304 638.396945261023 674.059260445584 1.05586228983282 0.0784216843832503 0.638281272834045 1 10.6826 10.5314 10.3873 11.9633 GeneID:63931,Genbank:NM_022100.2,HGNC:HGNC:14049,MIM:611978 mitochondrial ribosomal protein S14 GO:0003723,GO:0003735,GO:0005743,GO:0005761,GO:0005763,GO:0006412,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial small ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS15 1643.41325587313 1722.13823138232 1564.68828036393 0.908572989003325 -0.138325678784141 0.484903511397373 1 57.284 63.2554 50.8593 60.0228 GeneID:64960,Genbank:NM_031280.3,HGNC:HGNC:14504,MIM:611979 mitochondrial ribosomal protein S15 GO:0003723,GO:0003735,GO:0005634,GO:0005730,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0032543,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|nucleus|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS16 3636.01149273506 3502.25572467221 3769.76726079792 1.07638263940614 0.106191027561933 0.43706570293371 1 64.5474 68.5531 71.4614 73.7894 GeneID:51021,Genbank:NM_016065.3,HGNC:HGNC:14048,MIM:609204 mitochondrial ribosomal protein S16 GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0005829,GO:0006412,GO:0032543,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|cytosol|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS17 742.22590633193 812.292806714168 672.159005949692 0.82748363692726 -0.273197311254276 0.0883807912763053 0.973525964980265 61.7231 60.8198 50.5537 50.4189 GeneID:51373,Genbank:NM_015969.2,HGNC:HGNC:14047,MIM:611980 mitochondrial ribosomal protein S17 GO:0003735,GO:0005743,GO:0005763,GO:0006412,GO:0019843,GO:0032543,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|rRNA binding|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS18A 1207.5062531676 1222.36079828777 1192.65170804742 0.975695318205593 -0.0354973892489674 0.794324411442452 1 25.925 29.5772 27.2187 27.8744 GeneID:55168,Genbank:NM_001193343.1,HGNC:HGNC:14515,MIM:611981 mitochondrial ribosomal protein S18A GO:0003735,GO:0005743,GO:0005763,GO:0006412,GO:0022627,GO:0032543,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|cytosolic small ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS18B 1764.23870191651 1775.62264077972 1752.8547630533 0.987177524546308 -0.018618546423836 0.875595403949017 1 36.395 40.7237 37.8562 38.9124 GeneID:28973,Genbank:XM_024446408.1,HGNC:HGNC:14516,MIM:611982 mitochondrial ribosomal protein S18B GO:0003735,GO:0005654,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0030054,GO:0032543,GO:0070125,GO:0070126 structural constituent of ribosome|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|cell junction|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa05203 Viral carcinogenesis MRPS18C 624.457944555044 645.123674719479 603.79221439061 0.935932501086955 -0.0955236076625902 0.57166556521627 1 19.6271 20.4175 18.3283 20.6094 GeneID:51023,Genbank:NM_016067.3,HGNC:HGNC:16633,MIM:611983 mitochondrial ribosomal protein S18C GO:0003735,GO:0005743,GO:0005763,GO:0006412,GO:0022627,GO:0032543,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|cytosolic small ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS2 1653.60554127037 1760.34418342478 1546.86689911595 0.878729803910561 -0.186508468179181 0.183665412612017 1 46.6738 48.5426 41.6157 44.1458 GeneID:51116,Genbank:XM_006717136.3,HGNC:HGNC:14495,MIM:611971 mitochondrial ribosomal protein S2 GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0032543,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS21 1545.06094518448 1554.45941067546 1535.66247969351 0.987907737665675 -0.0175517824574824 0.89980048029658 1 32.2514 35.0786 32.4204 37.2016 GeneID:54460,Genbank:NM_018997.3,HGNC:HGNC:14046,MIM:611984 mitochondrial ribosomal protein S21 GO:0003723,GO:0003735,GO:0005743,GO:0005763,GO:0006412,GO:0032543,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS22 694.848217284442 724.792573828719 664.903860740166 0.917371237991319 -0.124422419054331 0.445750523427329 1 12.2232 13.1912 11.1415 10.8031 GeneID:56945,Genbank:XM_006713703.4,HGNC:HGNC:14508,MIM:605810 mitochondrial ribosomal protein S22 GO:0003735,GO:0005739,GO:0005743,GO:0005761,GO:0005763,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial small ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPS23 1324.65410361863 1421.86381715568 1227.44439008158 0.863264382475803 -0.212125629488207 0.199713434136428 1 34.9259 38.2827 28.6427 34.2576 GeneID:51649,Genbank:NM_016070.3,HGNC:HGNC:14509,MIM:611985 mitochondrial ribosomal protein S23 GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005840,GO:0031965,GO:0045111,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|ribosome|nuclear membrane|intermediate filament cytoskeleton|mitochondrial translational elongation|mitochondrial translational termination MRPS24 7.9367134728273 7.14915727551272 8.72426967014188 1.22032140767475 0.287261174172958 0.844301987206308 1 176.764 179.66 153.894 163.078 GeneID:64951,Genbank:NM_032014.2,HGNC:HGNC:14510,MIM:611986 mitochondrial ribosomal protein S24 GO:0003723,GO:0003735,GO:0005743,GO:0005761,GO:0005763,GO:0006412,GO:0032543,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial ribosome|mitochondrial small ribosomal subunit|translation|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPS25 1042.95775071661 1016.33194671439 1069.58355471883 1.05239588126359 0.0736775073866542 0.635330655400724 1 8.44328 8.75587 9.32569 8.8961 GeneID:64432,Genbank:NM_022497.4,HGNC:HGNC:14511,MIM:611987 mitochondrial ribosomal protein S25 GO:0003735,GO:0005739,GO:0005743,GO:0005840,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|ribosome|mitochondrial translational elongation|mitochondrial translational termination MRPS26 756.531536416831 807.489162244819 705.573910588843 0.873787468091024 -0.194645680170215 0.213722742336794 1 39.7469 42.5614 34.9545 38.8258 GeneID:64949,Genbank:NM_030811.3,HGNC:HGNC:14045,MIM:611988 mitochondrial ribosomal protein S26 GO:0003723,GO:0005654,GO:0005739,GO:0005743,GO:0005763,GO:0042769,GO:0070125,GO:0070126 RNA binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|DNA damage response, detection of DNA damage|mitochondrial translational elongation|mitochondrial translational termination MRPS27 2605.57681781608 2722.06648211295 2489.08715351922 0.914410860232598 -0.129085556699506 0.343946816949351 1 33.0614 34.9895 32.6309 29.7755 GeneID:23107,Genbank:NM_001286751.1,HGNC:HGNC:14512,MIM:611989 mitochondrial ribosomal protein S27 GO:0000049,GO:0005737,GO:0005739,GO:0005743,GO:0005763,GO:0008283,GO:0019843,GO:0070125,GO:0070126,GO:0070131,GO:0097177 tRNA binding|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|cell proliferation|rRNA binding|mitochondrial translational elongation|mitochondrial translational termination|positive regulation of mitochondrial translation|mitochondrial ribosome binding MRPS28 680.526610135121 722.880314495574 638.172905774668 0.882819594029178 -0.179809444545979 0.395721587395677 1 33.4251 34.273 26.0857 32.7449 GeneID:28957,Genbank:NM_014018.2,HGNC:HGNC:14513,MIM:611990 mitochondrial ribosomal protein S28 GO:0003723,GO:0005739,GO:0005743,GO:0005763,GO:0070125,GO:0070126 RNA binding|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|mitochondrial translational elongation|mitochondrial translational termination MRPS30 1138.61195184934 1212.96218075546 1064.26172294322 0.877407177097951 -0.188681587389036 0.206016776660333 1 31.9471 33.8066 30.5046 28.0028 GeneID:10884,Genbank:NM_016640.3,HGNC:HGNC:8769,MIM:611991 mitochondrial ribosomal protein S30 GO:0003723,GO:0003735,GO:0005743,GO:0005840,GO:0006915,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|ribosome|apoptotic process|mitochondrial translational elongation|mitochondrial translational termination MRPS31 185.295522978634 176.749028969773 193.842016987494 1.09670767707949 0.133179032552095 0.569609994031338 1 3.79452 3.80446 4.11249 4.55689 GeneID:10240,Genbank:NM_005830.3,HGNC:HGNC:16632,MIM:611992 mitochondrial ribosomal protein S31 GO:0003723,GO:0003735,GO:0005730,GO:0005739,GO:0005743,GO:0005763,GO:0019904,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|protein domain specific binding|mitochondrial translational elongation|mitochondrial translational termination MRPS33 688.182580536814 699.405930477161 676.959230596467 0.967906048687091 -0.0470610780397214 0.787593785899504 1 25.1354 27.2752 24.2365 28.0973 GeneID:51650,Genbank:NM_053035.2,HGNC:HGNC:16634,MIM:611993 mitochondrial ribosomal protein S33 GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination MRPS34 2177.91057211532 2097.62389282676 2258.19725140389 1.07655011898284 0.106415485993629 0.593209767332356 1 72.7631 82.8123 80.9832 89.5703 GeneID:65993,Genbank:XM_017023595.1,HGNC:HGNC:16618,MIM:611994 mitochondrial ribosomal protein S34 GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0032543,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination MRPS35 784.45636358447 826.436216785176 742.476510383764 0.898407518092546 -0.154558094275461 0.346686727451671 1 17.5189 16.0548 15.7123 13.8715 GeneID:60488,Genbank:NM_021821.3,HGNC:HGNC:16635,MIM:611995 mitochondrial ribosomal protein S35 GO:0003723,GO:0003735,GO:0005743,GO:0005763,GO:0042769,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|DNA damage response, detection of DNA damage|mitochondrial translational elongation|mitochondrial translational termination MRPS36 646.707746851226 662.967141942937 630.448351759516 0.950949620085062 -0.0725591836424516 0.690821004534658 1 22.0591 22.068 18.8594 22.5634 GeneID:92259,Genbank:NM_033281.5,HGNC:HGNC:16631,MIM:611996 mitochondrial ribosomal protein S36 GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0009353,GO:0070125,GO:0070126 structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial oxoglutarate dehydrogenase complex|mitochondrial translational elongation|mitochondrial translational termination MRPS5 1583.37188873221 1579.63534861892 1587.10842884551 1.00473088946327 0.00680913680072312 0.97923926318766 1 14.9991 16.5522 16.4129 16.2754 GeneID:64969,Genbank:NM_001321996.1,HGNC:HGNC:14498,MIM:611972 mitochondrial ribosomal protein S5 GO:0003723,GO:0003735,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0070125,GO:0070126 RNA binding|structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS6 1502.47052051408 1435.79753881944 1569.14350220872 1.09287240003136 0.128124966802786 0.390173142336262 1 97.8635 108.884 107.778 115.768 GeneID:64968,Genbank:NM_032476.3,HGNC:HGNC:14051,MIM:611973 mitochondrial ribosomal protein S6 GO:0003735,GO:0005743,GO:0005763,GO:0006412,GO:0015935,GO:0032543,GO:0070125,GO:0070126,GO:0070181 structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|small ribosomal subunit|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination|small ribosomal subunit rRNA binding hsa03010 Ribosome MRPS7 2585.54315615493 2556.62833000863 2614.45798230123 1.02261949913244 0.0322694404602686 0.83234077594891 1 65.8089 70.4583 69.7645 72.4676 GeneID:51081,Genbank:NM_015971.3,HGNC:HGNC:14499,MIM:611974 mitochondrial ribosomal protein S7 GO:0000028,GO:0003723,GO:0003729,GO:0003735,GO:0005743,GO:0005763,GO:0006412,GO:0019843,GO:0032543,GO:0070125,GO:0070126 ribosomal small subunit assembly|RNA binding|mRNA binding|structural constituent of ribosome|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|rRNA binding|mitochondrial translation|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRPS9 406.932197567784 421.328808162654 392.535586972914 0.931660924598764 -0.102123109328987 0.577959546154621 1 7.21916 7.51485 7.36329 7.27167 GeneID:64965,Genbank:NM_182640.2,HGNC:HGNC:14501,MIM:611975 mitochondrial ribosomal protein S9 GO:0000462,GO:0003723,GO:0003735,GO:0005730,GO:0005739,GO:0005743,GO:0005763,GO:0006412,GO:0042769,GO:0070125,GO:0070126 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|nucleolus|mitochondrion|mitochondrial inner membrane|mitochondrial small ribosomal subunit|translation|DNA damage response, detection of DNA damage|mitochondrial translational elongation|mitochondrial translational termination hsa03010 Ribosome MRRF 442.152292830265 462.177222313639 422.127363346892 0.913345234180387 -0.130767809161812 0.458209681072871 1 3.12278 3.50575 3.29335 3.03823 GeneID:92399,Genbank:NM_001346339.1,HGNC:HGNC:7234,MIM:604602 mitochondrial ribosome recycling factor GO:0005739,GO:0005759,GO:0006412,GO:0032790,GO:0043023,GO:0070126 mitochondrion|mitochondrial matrix|translation|ribosome disassembly|ribosomal large subunit binding|mitochondrial translational termination MRS2 912.900801164333 1075.15809825778 750.643504070886 0.698170348423411 -0.518349008536498 0.000842164194657941 0.0905241727626952 8.96635 9.34554 6.17021 6.79804 GeneID:57380,Genbank:NM_001286264.1,HGNC:HGNC:13785 MRS2, magnesium transporter GO:0005739,GO:0005743,GO:0006089,GO:0015095,GO:0016021,GO:0045016,GO:0055085 mitochondrion|mitochondrial inner membrane|lactate metabolic process|magnesium ion transmembrane transporter activity|integral component of membrane|mitochondrial magnesium ion transmembrane transport|transmembrane transport MRTO4 2555.89849615422 2817.22657798694 2294.5704143215 0.814478477610096 -0.296051518488229 0.0299830303453767 0.685033115565696 35.513 39.3769 28.8254 32.2832 GeneID:51154,Genbank:NM_016183.3,HGNC:HGNC:18477 MRT4 homolog, ribosome maturation factor GO:0000027,GO:0000956,GO:0003723,GO:0005730,GO:0005737,GO:0006364 ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process|RNA binding|nucleolus|cytoplasm|rRNA processing MS4A2 5.0917083923298 5.82302189369546 4.36039489096415 0.748819937580024 -0.417309247219116 0.852126086394265 1 0.0582812 0.0189925 0.0282527 0.0526193 GeneID:2206,Genbank:XM_005273846.4,HGNC:HGNC:7316,MIM:147138 membrane spanning 4-domains A2 GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0009897,GO:0019863,GO:0032998,GO:0038095 plasma membrane|integral component of plasma membrane|inflammatory response|immune response|external side of plasma membrane|IgE binding|Fc-epsilon receptor I complex|Fc-epsilon receptor signaling pathway hsa04071,hsa04072,hsa04664,hsa05310 Sphingolipid signaling pathway|Phospholipase D signaling pathway|Fc epsilon RI signaling pathway|Asthma MS4A3 72.1894331292492 66.3507273621289 78.0281388963694 1.17599523017295 0.23388220862684 0.519167910203188 1 1.27169 1.63969 1.77632 1.72978 GeneID:932,Genbank:NM_006138.4,HGNC:HGNC:7317,MIM:606498 membrane spanning 4-domains A3 GO:0005886,GO:0016021,GO:0035579,GO:0043312,GO:0048471,GO:0051726 plasma membrane|integral component of membrane|specific granule membrane|neutrophil degranulation|perinuclear region of cytoplasm|regulation of cell cycle MSANTD1 4.26435524778907 4.65077399104097 3.87793650453717 0.833826049601086 -0.262181650729483 0.950444076485448 1 0.0304728 0.0221049 0.0172589 0.0106372 GeneID:345222,Genbank:XM_011513467.3,HGNC:HGNC:33741 Myb/SANT DNA binding domain containing 1 MSANTD2 179.692928317373 176.172713673553 183.213142961193 1.03996322211784 0.0565325089371384 0.831068875258634 1 0.273696 0.306509 0.367054 0.270322 GeneID:79684,Genbank:XM_017018298.2,HGNC:HGNC:26266 Myb/SANT DNA binding domain containing 2 MSANTD3 641.983767093554 578.792564667566 705.174969519542 1.21835526675185 0.284934877781562 0.0856301148318333 0.964561165794104 15.8575 17.1113 21.187 18.869 GeneID:91283,Genbank:NM_001198807.1,HGNC:HGNC:23370 Myb/SANT DNA binding domain containing 3 GO:0042802 identical protein binding MSANTD4 264.994081075671 256.638442142221 273.34972000912 1.06511603533518 0.0910106083700863 0.644609985181298 1 2.41321 2.1 2.63325 2.19646 GeneID:84437,Genbank:NM_001318750.1,HGNC:HGNC:29383 Myb/SANT DNA binding domain containing 4 with coiled-coils GO:0005634 nucleus MSH2 511.506851106989 531.101751198539 491.911951015439 0.926210372881166 -0.110588180622241 0.550674840032108 1 1.97331 1.64848 1.83472 1.59131 GeneID:4436,Genbank:NM_000251.2,HGNC:HGNC:7325,MIM:609309 mutS homolog 2 hsa01524,hsa03430,hsa05200,hsa05210 Platinum drug resistance|Mismatch repair|Pathways in cancer|Colorectal cancer MSH3 391.639638085245 400.399816702543 382.879459467947 0.956242844018055 -0.0645510484700511 0.745262305580963 1 2.9614 2.9889 3.08685 2.54992 GeneID:4437,Genbank:NM_002439.4,HGNC:HGNC:7326,MIM:600887 mutS homolog 3 hsa01524,hsa03430,hsa05200,hsa05210 Platinum drug resistance|Mismatch repair|Pathways in cancer|Colorectal cancer MSH4 1.21723886981142 0.980142803914724 1.45433493570811 1.48379902387637 0.569295696478757 1 1 0 0.0118888 0 0.0109188 GeneID:4438,Genbank:NM_002440.3,HGNC:HGNC:7327,MIM:602105 mutS homolog 4 MSH5 254.400752365578 261.164754619423 247.636750111733 0.948201262733928 -0.0767347805630219 0.724492363024808 1 2.39683 2.05918 2.10197 2.33205 GeneID:4439,Genbank:NM_002441.4,HGNC:HGNC:7328,MIM:603382 mutS homolog 5 MSH6 1651.83690407584 1756.6224749604 1547.05133319127 0.880696538524104 -0.183283099333571 0.206446007086176 1 12.6887 12.4096 12.7257 9.88294 GeneID:2956,Genbank:NM_000179.2,HGNC:HGNC:7329,MIM:600678 mutS homolog 6 hsa01524,hsa03430,hsa05200,hsa05210 Platinum drug resistance|Mismatch repair|Pathways in cancer|Colorectal cancer MSI1 87.831334481859 87.4620152658725 88.2006536978456 1.00844524825695 0.0121327575131378 1 1 0.462983 0.590899 0.503653 0.503281 GeneID:4440,Genbank:XM_011538361.3,HGNC:HGNC:7330,MIM:603328 musashi RNA binding protein 1 GO:0003723,GO:0005634,GO:0005737,GO:0005844,GO:0007399,GO:0008266,GO:0042802 RNA binding|nucleus|cytoplasm|polysome|nervous system development|poly(U) RNA binding|identical protein binding hsa03015 mRNA surveillance pathway MSI2 3019.83148596394 3048.37825622481 2991.28471570308 0.981270847735137 -0.0272766946789537 0.853156711568078 1 6.45181 6.19828 6.72092 5.75494 GeneID:124540,Genbank:NM_001322250.1,HGNC:HGNC:18585,MIM:607897 musashi RNA binding protein 2 GO:0003727,GO:0005737,GO:0005844,GO:0008266,GO:0048864 single-stranded RNA binding|cytoplasm|polysome|poly(U) RNA binding|stem cell development hsa03015 mRNA surveillance pathway MSL1 1968.21646444962 1862.67000288193 2073.7629260173 1.11332813800016 0.154878869673778 0.276501187712371 1 13.8143 14.5569 16.8219 15.4167 GeneID:339287,Genbank:XM_005257298.4,HGNC:HGNC:27905,MIM:614801 male specific lethal 1 homolog GO:0005654,GO:0043984,GO:0072487 nucleoplasm|histone H4-K16 acetylation|MSL complex MSL2 292.214291662204 294.132791718659 290.295791605749 0.98695487133383 -0.0189439761543963 0.969205241329442 1 2.53868 2.03331 2.41649 2.2905 GeneID:55167,Genbank:NM_018133.3,HGNC:HGNC:25544,MIM:614802 MSL complex subunit 2 GO:0005654,GO:0016874,GO:0043984,GO:0046872,GO:0061630,GO:0072487 nucleoplasm|ligase activity|histone H4-K16 acetylation|metal ion binding|ubiquitin protein ligase activity|MSL complex MSL3 626.894615165275 644.585577042837 609.203653287714 0.945109035921275 -0.0814473142219175 0.629570347520671 1 4.19799 4.08459 4.22124 3.48402 GeneID:10943,Genbank:NM_078629.3,HGNC:HGNC:7370,MIM:300609 MSL complex subunit 3 GO:0003677,GO:0005654,GO:0006338,GO:0006342,GO:0006351,GO:0016575,GO:0035064,GO:0035267,GO:0043968,GO:0043984,GO:0072487 DNA binding|nucleoplasm|chromatin remodeling|chromatin silencing|transcription, DNA-templated|histone deacetylation|methylated histone binding|NuA4 histone acetyltransferase complex|histone H2A acetylation|histone H4-K16 acetylation|MSL complex MSLN 17.1406631935291 21.1975317980055 13.0837945890526 0.617231983125681 -0.696115274875468 0.330733486551371 1 0.328905 0.214882 0.208835 0.238704 GeneID:10232,Genbank:NM_005823.5,HGNC:HGNC:7371,MIM:601051 mesothelin GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0005886,GO:0006501,GO:0007155,GO:0007160,GO:0009986,GO:0016020,GO:0031016,GO:0031225,GO:0043687,GO:0044267 extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|plasma membrane|C-terminal protein lipidation|cell adhesion|cell-matrix adhesion|cell surface|membrane|pancreas development|anchored component of membrane|post-translational protein modification|cellular protein metabolic process MSMO1 1052.98464572948 1105.66698669298 1000.30230476599 0.904704867564029 -0.144480861303796 0.341952727241517 1 20.8549 22.1572 20.879 17.9583 GeneID:6307,Genbank:NM_006745.4,HGNC:HGNC:10545,MIM:607545 methylsterol monooxygenase 1 GO:0000254,GO:0005506,GO:0005783,GO:0005789,GO:0005886,GO:0006631,GO:0006695,GO:0008202,GO:0016021,GO:0016126 C-4 methylsterol oxidase activity|iron ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|fatty acid metabolic process|cholesterol biosynthetic process|steroid metabolic process|integral component of membrane|sterol biosynthetic process hsa00100 Steroid biosynthesis MSMP 48.752792740547 52.4464316636909 45.059153817403 0.85914622574023 -0.219024397520416 0.640863982073367 1 0.871716 1.47745 1.18078 1.30047 GeneID:692094,Genbank:NM_001044264.2,HGNC:HGNC:29663,MIM:612191 microseminoprotein, prostate associated GO:0005615,GO:0005737 extracellular space|cytoplasm MSN 25875.6167450378 25551.0778656145 26200.1556244611 1.02540314589703 0.0361912289869966 0.783697588581858 1 186.215 191.545 189.072 201.864 GeneID:4478,Genbank:XM_005262269.2,HGNC:HGNC:7373,MIM:309845 moesin hsa04530,hsa04670,hsa04810,hsa05162,hsa05205 Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Measles|Proteoglycans in cancer MSR1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0076295 0 0 GeneID:4481,Genbank:NM_138716.2,HGNC:HGNC:7376,MIM:153622 macrophage scavenger receptor 1 hsa04145 Phagosome MSRA 823.578380629283 747.211396804918 899.945364453647 1.20440529721819 0.26832095845388 0.0940196026481055 0.992628843778549 4.43303 5.18316 6.41121 5.85403 GeneID:4482,Genbank:XM_017013448.2,HGNC:HGNC:7377,MIM:601250 methionine sulfoxide reductase A GO:0005654,GO:0005739,GO:0005829,GO:0006464,GO:0006555,GO:0006979,GO:0008113,GO:0015629,GO:0016020,GO:0030091,GO:0070062 nucleoplasm|mitochondrion|cytosol|cellular protein modification process|methionine metabolic process|response to oxidative stress|peptide-methionine (S)-S-oxide reductase activity|actin cytoskeleton|membrane|protein repair|extracellular exosome MSRB1 680.817771211835 657.510746938215 704.124795485455 1.07089473254134 0.0988166721473824 0.56704710812047 1 20.2772 21.9642 21.3984 24.1077 GeneID:51734,Genbank:NM_016332.3,HGNC:HGNC:14133,MIM:606216 methionine sulfoxide reductase B1 GO:0003779,GO:0005634,GO:0005829,GO:0006979,GO:0008270,GO:0015629,GO:0030041,GO:0030091,GO:0033743,GO:0033745,GO:0045087,GO:0070191 actin binding|nucleus|cytosol|response to oxidative stress|zinc ion binding|actin cytoskeleton|actin filament polymerization|protein repair|peptide-methionine (R)-S-oxide reductase activity|L-methionine-(R)-S-oxide reductase activity|innate immune response|methionine-R-sulfoxide reductase activity MSRB2 282.091219785475 250.162669713152 314.019769857797 1.25526230679368 0.327988869489486 0.111998586948978 1 2.95316 2.77109 3.44459 3.30678 GeneID:22921,Genbank:NM_012228.3,HGNC:HGNC:17061,MIM:613782 methionine sulfoxide reductase B2 GO:0003700,GO:0003779,GO:0005739,GO:0005829,GO:0006979,GO:0008270,GO:0030041,GO:0030091,GO:0033743,GO:0033745 DNA binding transcription factor activity|actin binding|mitochondrion|cytosol|response to oxidative stress|zinc ion binding|actin filament polymerization|protein repair|peptide-methionine (R)-S-oxide reductase activity|L-methionine-(R)-S-oxide reductase activity MSRB3 673.336749217335 620.639721931827 726.033776502843 1.1698151936569 0.226280632155912 0.165088100727435 1 4.72969 4.62935 6.04417 4.66001 GeneID:253827,Genbank:XM_024448922.1,HGNC:HGNC:27375,MIM:613719 methionine sulfoxide reductase B3 GO:0005739,GO:0005783,GO:0006979,GO:0008270,GO:0030091,GO:0033743,GO:0033745 mitochondrion|endoplasmic reticulum|response to oxidative stress|zinc ion binding|protein repair|peptide-methionine (R)-S-oxide reductase activity|L-methionine-(R)-S-oxide reductase activity MSS51 15.8438898572938 17.1426904133997 14.5450893011879 0.84847179470841 -0.237061393057717 0.800859043450382 1 0.171604 0.368253 0.307967 0.10115 GeneID:118490,Genbank:NM_001024593.1,HGNC:HGNC:21000,MIM:614773 MSS51 mitochondrial translational activator GO:0035176,GO:0046872 social behavior|metal ion binding MST1 33.4360874619268 24.2340127591196 42.6381621647341 1.75943466682747 0.8151119434175 0.0966702282287763 1 0.237675 0.149943 0.351071 0.409937 GeneID:4485,Genbank:XM_006713166.2,HGNC:HGNC:7380,MIM:142408 macrophage stimulating 1 GO:0004252,GO:0005576,GO:0005615,GO:0030971,GO:0045721,GO:0048012,GO:0070062,GO:2000479 serine-type endopeptidase activity|extracellular region|extracellular space|receptor tyrosine kinase binding|negative regulation of gluconeogenesis|hepatocyte growth factor receptor signaling pathway|extracellular exosome|regulation of cAMP-dependent protein kinase activity MST1L 6.01044720108071 5.23689794236822 6.7839964597932 1.29542269764481 0.373422927481021 0.8008152484515 1 0.010347 0.00951887 0.0392575 0.0365929 GeneID:11223,Genbank:NM_001271733.1,HGNC:HGNC:7390 macrophage stimulating 1 like GO:0004252,GO:0005615 serine-type endopeptidase activity|extracellular space MST1R 4.42604037991986 3.03648096111406 5.81559979872566 1.91524329419539 0.937527669974993 0.573306158872578 1 0.0193752 0.0169174 0.0542298 0.0337235 GeneID:4486,Genbank:XM_011533743.2,HGNC:HGNC:7381,MIM:600168 macrophage stimulating 1 receptor MSTN 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0153272 0 0 0 GeneID:2660,Genbank:NM_005259.2,HGNC:HGNC:4223,MIM:601788 myostatin hsa04060 Cytokine-cytokine receptor interaction MSTO1 495.393316468941 501.295673575112 489.49095936277 0.976451593670951 -0.0343795687495328 0.837662323254592 1 4.3214 4.36701 4.49769 4.16721 GeneID:55154,Genbank:NM_001350779.1,HGNC:HGNC:29678,MIM:617619 misato 1, mitochondrial distribution and morphology regulator GO:0003924,GO:0005737,GO:0005741,GO:0007005,GO:0048311 GTPase activity|cytoplasm|mitochondrial outer membrane|mitochondrion organization|mitochondrion distribution MSX1 167.387108221776 193.267377812268 141.506838631284 0.732181707192911 -0.449726365046794 0.0614864533833542 0.886147929923425 5.10884 5.60613 3.82753 3.87639 GeneID:4487,Genbank:NM_002448.3,HGNC:HGNC:7391,MIM:142983 msh homeobox 1 GO:0000902,GO:0000977,GO:0000982,GO:0001227,GO:0001228,GO:0001701,GO:0002039,GO:0003198,GO:0005654,GO:0007517,GO:0008285,GO:0009952,GO:0010463,GO:0023019,GO:0030308,GO:0030513,GO:0030900,GO:0030901,GO:0034504,GO:0035115,GO:0035116,GO:0035326,GO:0035880,GO:0042474,GO:0042475,GO:0042481,GO:0043066,GO:0048863,GO:0050821,GO:0051154,GO:0060021,GO:0060325,GO:0060349,GO:0060536,GO:0061180,GO:0061312,GO:0090427,GO:1902255,GO:2000678,GO:2001055 cell morphogenesis|RNA polymerase II regulatory region sequence-specific DNA binding|transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|in utero embryonic development|p53 binding|epithelial to mesenchymal transition involved in endocardial cushion formation|nucleoplasm|muscle organ development|negative regulation of cell proliferation|anterior/posterior pattern specification|mesenchymal cell proliferation|signal transduction involved in regulation of gene expression|negative regulation of cell growth|positive regulation of BMP signaling pathway|forebrain development|midbrain development|protein localization to nucleus|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|enhancer binding|embryonic nail plate morphogenesis|middle ear morphogenesis|odontogenesis of dentin-containing tooth|regulation of odontogenesis|negative regulation of apoptotic process|stem cell differentiation|protein stabilization|negative regulation of striated muscle cell differentiation|palate development|face morphogenesis|bone morphogenesis|cartilage morphogenesis|mammary gland epithelium development|BMP signaling pathway involved in heart development|activation of meiosis|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of transcription regulatory region DNA binding|positive regulation of mesenchymal cell apoptotic process hsa05166 Human T-cell leukemia virus 1 infection MSX2 88.77572131712 93.7172736317324 83.8341690025077 0.89454340436683 -0.160776609540786 0.61403622713532 1 1.50465 1.82838 1.50819 1.78786 GeneID:4488,Genbank:XM_017009489.2,HGNC:HGNC:7392,MIM:123101 msh homeobox 2 GO:0000122,GO:0001649,GO:0005829,GO:0006351,GO:0007275,GO:0016607,GO:0043565,GO:0044212,GO:0045892 negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|cytosol|transcription, DNA-templated|multicellular organism development|nuclear speck|sequence-specific DNA binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated hsa05166 Human T-cell leukemia virus 1 infection MT1E 460.804981574769 417.159313919318 504.45064923022 1.20925179517336 0.274114679512761 0.282803282986588 1 13.695 13.7684 15.9323 18.7249 GeneID:4493,Genbank:NM_175617.3,HGNC:HGNC:7397,MIM:156351 metallothionein 1E hsa04978 Mineral absorption MT1F 130.179144253829 116.93292596736 143.425362540298 1.22656096521806 0.294618943664681 0.415316128483925 1 6.63754 8.39573 8.01922 13.5797 GeneID:4494,Genbank:NM_001301272.1,HGNC:HGNC:7398,MIM:156352 metallothionein 1F GO:0005623,GO:0006875,GO:0046872 cell|cellular metal ion homeostasis|metal ion binding hsa04978 Mineral absorption MT1X 449.181869037408 453.038353464973 445.325384609843 0.982975020114435 -0.0247733403916342 0.912728074882203 1 125.947 117.277 108.934 134.594 GeneID:4501,Genbank:NM_005952.3,HGNC:HGNC:7405,MIM:156359 metallothionein 1X hsa04978 Mineral absorption MT2A 4325.79980301617 4093.59498968936 4558.00461634297 1.1134478686395 0.155034013073269 0.242708193050437 1 1100.57 1012.35 1238.41 1143.89 GeneID:4502,Genbank:NM_005953.4,HGNC:HGNC:7406,MIM:156360 metallothionein 2A hsa04978 Mineral absorption MT3 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.177534 0 0 0.147883 GeneID:4504,Genbank:NM_005954.3,HGNC:HGNC:7408,MIM:139255 metallothionein 3 GO:0000060,GO:0001666,GO:0001934,GO:0005507,GO:0005622,GO:0005634,GO:0006112,GO:0006707,GO:0006829,GO:0006882,GO:0008021,GO:0008144,GO:0008270,GO:0010507,GO:0010628,GO:0010940,GO:0010942,GO:0014002,GO:0016234,GO:0016570,GO:0019430,GO:0030295,GO:0030308,GO:0030517,GO:0030949,GO:0032095,GO:0032148,GO:0033210,GO:0034599,GO:0035690,GO:0036091,GO:0043027,GO:0043066,GO:0043085,GO:0043154,GO:0043491,GO:0043524,GO:0044242,GO:0045892,GO:0045893,GO:0046870,GO:0048471,GO:0050821,GO:0051354,GO:0055069,GO:0055073,GO:0060049,GO:0060547,GO:0070371,GO:0070374,GO:0071276,GO:0071732,GO:0097214,GO:2000117,GO:2000376,GO:2000378 protein import into nucleus, translocation|response to hypoxia|positive regulation of protein phosphorylation|copper ion binding|intracellular|nucleus|energy reserve metabolic process|cholesterol catabolic process|zinc II ion transport|cellular zinc ion homeostasis|synaptic vesicle|drug binding|zinc ion binding|negative regulation of autophagy|positive regulation of gene expression|positive regulation of necrotic cell death|positive regulation of cell death|astrocyte development|inclusion body|histone modification|removal of superoxide radicals|protein kinase activator activity|negative regulation of cell growth|negative regulation of axon extension|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of response to food|activation of protein kinase B activity|leptin-mediated signaling pathway|cellular response to oxidative stress|cellular response to drug|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|positive regulation of catalytic activity|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein kinase B signaling|negative regulation of neuron apoptotic process|cellular lipid catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|cadmium ion binding|perinuclear region of cytoplasm|protein stabilization|negative regulation of oxidoreductase activity|zinc ion homeostasis|cadmium ion homeostasis|regulation of protein glycosylation|negative regulation of necrotic cell death|ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to cadmium ion|cellular response to nitric oxide|positive regulation of lysosomal membrane permeability|negative regulation of cysteine-type endopeptidase activity|positive regulation of oxygen metabolic process|negative regulation of reactive oxygen species metabolic process MTA1 1277.89758148717 1188.66154141229 1367.13362156205 1.15014541476433 0.201816274992969 0.178049245209728 1 8.23386 8.29414 10.3306 10.0294 GeneID:9112,Genbank:NM_004689.3,HGNC:HGNC:7410,MIM:603526 metastasis associated 1 MTA2 3691.22395434443 3823.34346049938 3559.10444818949 0.930887974088685 -0.10332053499931 0.434234264687235 1 38.1053 39.6053 38.2052 36.4798 GeneID:9219,Genbank:NM_004739.3,HGNC:HGNC:7411,MIM:603947 metastasis associated 1 family member 2 GO:0000118,GO:0000122,GO:0000790,GO:0000989,GO:0001085,GO:0001103,GO:0003682,GO:0003700,GO:0004407,GO:0005654,GO:0005667,GO:0006306,GO:0006333,GO:0008270,GO:0010762,GO:0016020,GO:0016581,GO:0042826,GO:0043044,GO:0043234,GO:0043565,GO:0044212,GO:0045944,GO:1901796 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|transcription factor activity, transcription factor binding|RNA polymerase II transcription factor binding|RNA polymerase II repressing transcription factor binding|chromatin binding|DNA binding transcription factor activity|histone deacetylase activity|nucleoplasm|transcription factor complex|DNA methylation|chromatin assembly or disassembly|zinc ion binding|regulation of fibroblast migration|membrane|NuRD complex|histone deacetylase binding|ATP-dependent chromatin remodeling|protein complex|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|regulation of signal transduction by p53 class mediator MTA3 563.500981381333 582.751353502802 544.250609259863 0.933932810260296 -0.098609332737273 0.564512811741418 1 2.10749 2.24839 2.23479 1.98385 GeneID:57504,Genbank:XM_005264459.2,HGNC:HGNC:23784,MIM:609050 metastasis associated 1 family member 3 MTAP 2058.94864534719 2267.53422912847 1850.36306156591 0.81602431301648 -0.293315957708043 0.0401581243516539 0.758464027333929 19.1138 17.1728 15.9425 13.9775 GeneID:4507,Genbank:NM_002451.3,HGNC:HGNC:7413,MIM:156540 methylthioadenosine phosphorylase GO:0004645,GO:0005634,GO:0005829,GO:0006139,GO:0006166,GO:0017061,GO:0019509,GO:0035722,GO:0070062 phosphorylase activity|nucleus|cytosol|nucleobase-containing compound metabolic process|purine ribonucleoside salvage|S-methyl-5-thioadenosine phosphorylase activity|L-methionine salvage from methylthioadenosine|interleukin-12-mediated signaling pathway|extracellular exosome hsa00270 Cysteine and methionine metabolism MTBP 163.967113228893 183.49435873759 144.439867720195 0.78716244310679 -0.345266706065075 0.185406932761376 1 1.43812 1.22525 1.22213 0.849249 GeneID:27085,Genbank:NM_022045.4,HGNC:HGNC:7417,MIM:605927 MDM2 binding protein GO:0000776,GO:0000785,GO:0007050,GO:0007089,GO:0008285,GO:0034501,GO:0045839 kinetochore|chromatin|cell cycle arrest|traversing start control point of mitotic cell cycle|negative regulation of cell proliferation|protein localization to kinetochore|negative regulation of mitotic nuclear division MTCH1 7144.349053486 6895.88437924843 7392.81372772357 1.07206172858271 0.100387977583212 0.459220165438112 1 59.0498 61.5932 66.1342 66.7845 GeneID:23787,Genbank:NM_014341.2,HGNC:HGNC:17586,MIM:610449 mitochondrial carrier 1 GO:0005622,GO:0005739,GO:0005743,GO:0006915,GO:0006919,GO:0009966,GO:0016020,GO:0016021,GO:0043065,GO:0045161 intracellular|mitochondrion|mitochondrial inner membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of signal transduction|membrane|integral component of membrane|positive regulation of apoptotic process|neuronal ion channel clustering MTCH2 3951.36808214605 3763.60175873441 4139.1344055577 1.09978012310994 0.13721511738002 0.306761581762774 1 30.0925 31.587 34.0119 34.378 GeneID:23788,Genbank:XM_011519959.2,HGNC:HGNC:17587,MIM:613221 mitochondrial carrier 2 GO:0005743,GO:0016021 mitochondrial inner membrane|integral component of membrane MTCL1 2102.34699025817 2109.0081539288 2095.68582658754 0.993683131420598 -0.00914222057283239 0.939856090641388 1 5.17946 5.39384 5.9065 4.86775 GeneID:23255,Genbank:XM_005258099.5,HGNC:HGNC:29121,MIM:615766 microtubule crosslinking factor 1 GO:0000922,GO:0001578,GO:0003723,GO:0005615,GO:0005737,GO:0005856,GO:0008017,GO:0010506,GO:0016324,GO:0016327,GO:0016328,GO:0030496,GO:0042803,GO:0045197,GO:0090314,GO:0097427,GO:2000576 spindle pole|microtubule bundle formation|RNA binding|extracellular space|cytoplasm|cytoskeleton|microtubule binding|regulation of autophagy|apical plasma membrane|apicolateral plasma membrane|lateral plasma membrane|midbody|protein homodimerization activity|establishment or maintenance of epithelial cell apical/basal polarity|positive regulation of protein targeting to membrane|microtubule bundle|positive regulation of microtubule motor activity MTCP1 44.3008428707427 39.1664775361572 49.4352082053283 1.26218162355017 0.335919524062001 0.434982389397994 1 1.05776 0.968797 1.45132 1.18508 GeneID:4515,Genbank:NM_001018025.3,HGNC:HGNC:7423,MIM:300116 mature T cell proliferation 1 hsa04151 PI3K-Akt signaling pathway MTDH 1994.42798654617 2147.09538510911 1841.76058798324 0.857791694191385 -0.221300748145547 0.151797726914609 1 11.1649 10.3361 10.5203 8.14297 GeneID:92140,Genbank:XM_011517369.3,HGNC:HGNC:29608,MIM:610323 metadherin GO:0000122,GO:0001085,GO:0001650,GO:0003713,GO:0003723,GO:0003725,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005923,GO:0010508,GO:0016021,GO:0016324,GO:0016604,GO:0031663,GO:0031965,GO:0043066,GO:0043123,GO:0045766,GO:0046581,GO:0048471,GO:0051059,GO:0051092,GO:0051897,GO:0070830 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor binding|fibrillar center|transcription coactivator activity|RNA binding|double-stranded RNA binding|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|bicellular tight junction|positive regulation of autophagy|integral component of membrane|apical plasma membrane|nuclear body|lipopolysaccharide-mediated signaling pathway|nuclear membrane|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of angiogenesis|intercellular canaliculus|perinuclear region of cytoplasm|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein kinase B signaling|bicellular tight junction assembly MTERF1 140.248335973767 156.906041518054 123.590630429481 0.787672859717518 -0.344331528224512 0.198489737608131 1 2.85989 2.26376 2.24788 1.8351 GeneID:7978,Genbank:NM_001301134.1,HGNC:HGNC:21463,MIM:602318 mitochondrial transcription termination factor 1 GO:0003690,GO:0003723,GO:0005739,GO:0005759,GO:0005829,GO:0006353,GO:0006355,GO:0006393,GO:0007005,GO:0032392,GO:0042645 double-stranded DNA binding|RNA binding|mitochondrion|mitochondrial matrix|cytosol|DNA-templated transcription, termination|regulation of transcription, DNA-templated|termination of mitochondrial transcription|mitochondrion organization|DNA geometric change|mitochondrial nucleoid MTERF2 112.24339798436 100.414577124865 124.072218843854 1.23559967483179 0.305211396409503 0.277106495873133 1 0.403908 0.340953 0.542136 0.489293 GeneID:80298,Genbank:XM_017019985.2,HGNC:HGNC:30779,MIM:616929 mitochondrial transcription termination factor 2 GO:0003676,GO:0003677,GO:0003690,GO:0005739,GO:0005759,GO:0006355,GO:0006393,GO:0042645 nucleic acid binding|DNA binding|double-stranded DNA binding|mitochondrion|mitochondrial matrix|regulation of transcription, DNA-templated|termination of mitochondrial transcription|mitochondrial nucleoid MTERF3 221.397840370557 249.902921029512 192.892759711602 0.77187076852464 -0.373568772284387 0.0903962252661002 0.979717040875575 3.43636 3.72144 3.10168 2.5367 GeneID:51001,Genbank:NM_015942.4,HGNC:HGNC:24258,MIM:616930 mitochondrial transcription termination factor 3 GO:0003690,GO:0003727,GO:0005654,GO:0005739,GO:0005741,GO:0006351,GO:0008380,GO:0016236,GO:0019843,GO:0032502,GO:0042255,GO:0044212,GO:0045892 double-stranded DNA binding|single-stranded RNA binding|nucleoplasm|mitochondrion|mitochondrial outer membrane|transcription, DNA-templated|RNA splicing|macroautophagy|rRNA binding|developmental process|ribosome assembly|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated MTERF4 564.40756308219 585.547703090491 543.267423073888 0.927793619899028 -0.108124169557213 0.524306932694538 1 2.38169 2.5662 2.3944 2.26585 GeneID:130916,Genbank:XM_017003380.2,HGNC:HGNC:28785,MIM:615393 mitochondrial transcription termination factor 4 GO:0003690,GO:0003727,GO:0005739,GO:0005759,GO:0005762,GO:0005829,GO:0006355,GO:0006390,GO:0006626,GO:0007507,GO:0008380,GO:0019843,GO:0031167,GO:0032502,GO:0042255,GO:0043010 double-stranded DNA binding|single-stranded RNA binding|mitochondrion|mitochondrial matrix|mitochondrial large ribosomal subunit|cytosol|regulation of transcription, DNA-templated|transcription from mitochondrial promoter|protein targeting to mitochondrion|heart development|RNA splicing|rRNA binding|rRNA methylation|developmental process|ribosome assembly|camera-type eye development MTF1 561.360454710079 560.468834697259 562.252074722899 1.00318169345955 0.00458292650209835 0.999122056012812 1 2.06862 2.52128 2.69151 1.88693 GeneID:4520,Genbank:NM_005955.2,HGNC:HGNC:7428,MIM:600172 metal regulatory transcription factor 1 GO:0000978,GO:0001047,GO:0001077,GO:0003677,GO:0003700,GO:0003713,GO:0005634,GO:0005654,GO:0006357,GO:0006979,GO:0010038,GO:0035035,GO:0045944,GO:0046686,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|core promoter binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|transcription coactivator activity|nucleus|nucleoplasm|regulation of transcription from RNA polymerase II promoter|response to oxidative stress|response to metal ion|histone acetyltransferase binding|positive regulation of transcription from RNA polymerase II promoter|response to cadmium ion|metal ion binding MTF2 301.277328733708 312.245816280865 290.30884118655 0.929744534752764 -0.105093732510716 0.653522591497584 1 1.27181 1.06821 1.15249 0.990996 GeneID:22823,Genbank:XM_011541017.2,HGNC:HGNC:29535,MIM:609882 metal response element binding transcription factor 2 GO:0000122,GO:0000977,GO:0005737,GO:0005925,GO:0007379,GO:0016569,GO:0019827,GO:0035064,GO:0035098,GO:0045944,GO:0046872,GO:0048863,GO:0061086,GO:0061087,GO:1990830 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|cytoplasm|focal adhesion|segment specification|covalent chromatin modification|stem cell population maintenance|methylated histone binding|ESC/E(Z) complex|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|stem cell differentiation|negative regulation of histone H3-K27 methylation|positive regulation of histone H3-K27 methylation|cellular response to leukemia inhibitory factor MTFMT 372.308376228894 391.348208748993 353.268543708795 0.902696207140117 -0.14768754925594 0.440878125110588 1 4.95863 5.20316 4.34487 5.02366 GeneID:123263,Genbank:NM_139242.3,HGNC:HGNC:29666,MIM:611766 mitochondrial methionyl-tRNA formyltransferase GO:0004479,GO:0005739 methionyl-tRNA formyltransferase activity|mitochondrion hsa00670,hsa00970 One carbon pool by folate|Aminoacyl-tRNA biosynthesis MTFP1 758.797086803794 806.239462102156 711.354711505432 0.882311949418446 -0.180639270952231 0.337758854613261 1 29.8401 30.2675 24.6122 30.0797 GeneID:51537,Genbank:NM_016498.4,HGNC:HGNC:26945,MIM:610235 mitochondrial fission process 1 GO:0000266,GO:0005743,GO:0006915,GO:0014850,GO:0016021 mitochondrial fission|mitochondrial inner membrane|apoptotic process|response to muscle activity|integral component of membrane MTFR1 568.387285911739 616.757368335745 520.017203487733 0.843147127517819 -0.246143694301535 0.151333385994058 1 4.85868 4.60253 4.156 3.96163 GeneID:9650,Genbank:XM_006716484.2,HGNC:HGNC:29510 mitochondrial fission regulator 1 GO:0000266,GO:0005739,GO:0005829,GO:0005886,GO:0007005,GO:0009060 mitochondrial fission|mitochondrion|cytosol|plasma membrane|mitochondrion organization|aerobic respiration MTFR1L 1527.94134982575 1491.54899178214 1564.33370786936 1.04879807266689 0.0687369394933694 0.648732476346016 1 22.3854 24.2199 24.2183 25.0832 GeneID:56181,Genbank:NM_001099625.1,HGNC:HGNC:28836 mitochondrial fission regulator 1 like GO:0000266,GO:0005739,GO:0009060 mitochondrial fission|mitochondrion|aerobic respiration MTFR2 316.879302271763 322.143296869382 311.615307674143 0.967318925156751 -0.0479364700412175 0.84333671184875 1 2.549 2.1344 2.41945 2.16787 GeneID:113115,Genbank:XM_011535413.2,HGNC:HGNC:21115 mitochondrial fission regulator 2 GO:0000266,GO:0005739,GO:0007005,GO:0009060 mitochondrial fission|mitochondrion|mitochondrion organization|aerobic respiration MTG1 736.493880473609 722.313807854463 750.673953092755 1.03926291444231 0.0555606757815008 0.742251930661669 1 8.2295 8.77116 9.12905 9.16666 GeneID:92170,Genbank:NM_138384.3,HGNC:HGNC:32159 mitochondrial ribosome associated GTPase 1 GO:0003924,GO:0005525,GO:0005743,GO:0005759,GO:0005761,GO:0042254,GO:0044065,GO:0070129 GTPase activity|GTP binding|mitochondrial inner membrane|mitochondrial matrix|mitochondrial ribosome|ribosome biogenesis|regulation of respiratory system process|regulation of mitochondrial translation MTG2 1188.54052133317 1203.8155372534 1173.26550541295 0.974622331333133 -0.0370848157857501 0.782510066102938 1 5.56789 6.1531 5.65117 5.92043 GeneID:26164,Genbank:XM_024451870.1,HGNC:HGNC:16239,MIM:610919 mitochondrial ribosome associated GTPase 2 GO:0000287,GO:0003924,GO:0005525,GO:0005743,GO:0005759,GO:0005761,GO:0042254,GO:0044065,GO:0070129 magnesium ion binding|GTPase activity|GTP binding|mitochondrial inner membrane|mitochondrial matrix|mitochondrial ribosome|ribosome biogenesis|regulation of respiratory system process|regulation of mitochondrial translation MTHFD1 5959.48996020762 6078.85826129893 5840.12165911631 0.960726736515219 -0.0578019572661776 0.660972594461698 1 57.3835 58.661 56.2504 56.6256 GeneID:4522,Genbank:NM_005956.3,HGNC:HGNC:7432,MIM:172460 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 GO:0000105,GO:0001780,GO:0001843,GO:0004329,GO:0004477,GO:0004486,GO:0004487,GO:0004488,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006164,GO:0006555,GO:0006730,GO:0007507,GO:0009069,GO:0009070,GO:0009086,GO:0009113,GO:0009257,GO:0016020,GO:0019346,GO:0035999,GO:0046655,GO:0048702,GO:0048703,GO:0061053,GO:0070062 histidine biosynthetic process|neutrophil homeostasis|neural tube closure|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|ATP binding|cytoplasm|mitochondrion|cytosol|purine nucleotide biosynthetic process|methionine metabolic process|one-carbon metabolic process|heart development|serine family amino acid metabolic process|serine family amino acid biosynthetic process|methionine biosynthetic process|purine nucleobase biosynthetic process|10-formyltetrahydrofolate biosynthetic process|membrane|transsulfuration|tetrahydrofolate interconversion|folic acid metabolic process|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|somite development|extracellular exosome hsa00670 One carbon pool by folate MTHFD1L 2026.6977623654 2132.38648539784 1921.00903933296 0.900872826050833 -0.150604636102056 0.28165024950124 1 3.9235 4.27172 3.7375 3.93481 GeneID:25902,Genbank:NM_001242767.1,HGNC:HGNC:21055,MIM:611427 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like GO:0001843,GO:0004329,GO:0004477,GO:0004488,GO:0005524,GO:0005739,GO:0005759,GO:0006760,GO:0009113,GO:0009257,GO:0015942,GO:0016020,GO:0035999,GO:0042803,GO:0046653,GO:0046655,GO:0048702,GO:0048703 neural tube closure|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|ATP binding|mitochondrion|mitochondrial matrix|folic acid-containing compound metabolic process|purine nucleobase biosynthetic process|10-formyltetrahydrofolate biosynthetic process|formate metabolic process|membrane|tetrahydrofolate interconversion|protein homodimerization activity|tetrahydrofolate metabolic process|folic acid metabolic process|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis hsa00670 One carbon pool by folate MTHFD2 3030.62596909559 3377.55707451183 2683.69486367934 0.794566843572059 -0.331759502332473 0.0151256549144694 0.511744031201217 69.0687 71.1258 53.0022 59.0987 GeneID:10797,Genbank:NM_006636.3,HGNC:HGNC:7434,MIM:604887 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GO:0000287,GO:0004477,GO:0004487,GO:0004488,GO:0005615,GO:0005739,GO:0005759,GO:0006730,GO:0042301,GO:0046653,GO:0046655 magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|extracellular space|mitochondrion|mitochondrial matrix|one-carbon metabolic process|phosphate ion binding|tetrahydrofolate metabolic process|folic acid metabolic process hsa00670 One carbon pool by folate MTHFD2L 381.777597064128 401.063392893879 362.491801234378 0.903826695871726 -0.145881925095793 0.430666232699569 1 1.39967 1.57502 1.28511 1.41238 GeneID:441024,Genbank:NM_001351310.1,HGNC:HGNC:31865,MIM:614047 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like GO:0000105,GO:0004477,GO:0004487,GO:0004488,GO:0005739,GO:0005743,GO:0005759,GO:0006164,GO:0006730,GO:0009086,GO:0009256,GO:0035999,GO:0046655 histidine biosynthetic process|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|purine nucleotide biosynthetic process|one-carbon metabolic process|methionine biosynthetic process|10-formyltetrahydrofolate metabolic process|tetrahydrofolate interconversion|folic acid metabolic process hsa00670 One carbon pool by folate MTHFR 357.289424388615 325.901188951625 388.677659825605 1.1926242462506 0.254139572404587 0.184779006754222 1 1.52911 1.50916 1.84597 1.78044 GeneID:4524,Genbank:NM_005957.4,HGNC:HGNC:7436,MIM:607093 methylenetetrahydrofolate reductase hsa00670,hsa01523 One carbon pool by folate|Antifolate resistance MTHFS 3.73039069846356 4.55472144167109 2.90605995525603 0.63803242250306 -0.648298356483629 0.741986891973472 1 3.3196 3.39286 2.61628 3.26274 GeneID:10588,Genbank:NM_001199758.1,HGNC:HGNC:7437,MIM:604197 methenyltetrahydrofolate synthetase GO:0005524,GO:0005542,GO:0005737,GO:0005759,GO:0005829,GO:0006536,GO:0009396,GO:0015942,GO:0030272,GO:0035999,GO:0046653,GO:0046655,GO:0046657,GO:0046872 ATP binding|folic acid binding|cytoplasm|mitochondrial matrix|cytosol|glutamate metabolic process|folic acid-containing compound biosynthetic process|formate metabolic process|5-formyltetrahydrofolate cyclo-ligase activity|tetrahydrofolate interconversion|tetrahydrofolate metabolic process|folic acid metabolic process|folic acid catabolic process|metal ion binding hsa00670 One carbon pool by folate MTHFSD 322.547785252573 286.965034133785 358.130536371361 1.24799363606229 0.319610577433506 0.101547022918974 1 1.40936 1.24758 1.54775 1.67617 GeneID:64779,Genbank:NM_022764.2,HGNC:HGNC:25778,MIM:616820 methenyltetrahydrofolate synthetase domain containing GO:0003723,GO:0005737,GO:0008298 RNA binding|cytoplasm|intracellular mRNA localization MTIF2 354.704763308988 364.346255366654 345.063271251323 0.947075113765268 -0.0784492426264309 0.7128063009689 1 1.63006 1.46423 1.61324 1.375 GeneID:4528,Genbank:XM_017004164.2,HGNC:HGNC:7441,MIM:603766 mitochondrial translational initiation factor 2 GO:0003723,GO:0003743,GO:0003924,GO:0005525,GO:0005654,GO:0005739,GO:0006446,GO:0008135,GO:0032790,GO:0043024,GO:0070124 RNA binding|translation initiation factor activity|GTPase activity|GTP binding|nucleoplasm|mitochondrion|regulation of translational initiation|translation factor activity, RNA binding|ribosome disassembly|ribosomal small subunit binding|mitochondrial translational initiation MTIF3 381.160210222964 403.204957944485 359.115462501443 0.890652397560268 -0.167065606083527 0.458242764045559 1 2.56388 1.82152 2.12394 2.02519 GeneID:219402,Genbank:XM_006719772.4,HGNC:HGNC:29788 mitochondrial translational initiation factor 3 GO:0003743,GO:0005739,GO:0008135,GO:0032790,GO:0043022,GO:0043024,GO:0070124 translation initiation factor activity|mitochondrion|translation factor activity, RNA binding|ribosome disassembly|ribosome binding|ribosomal small subunit binding|mitochondrial translational initiation MTM1 196.34757130738 180.419660156899 212.27548245786 1.17656513859553 0.234581195213553 0.303520390309914 1 0.784969 0.767807 0.979787 0.82966 GeneID:4534,Genbank:XM_011531172.1,HGNC:HGNC:7448,MIM:300415 myotubularin 1 hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR1 1560.48987057487 1590.43551977134 1530.5442213784 0.962342831477036 -0.0553771539468519 0.693418286831177 1 7.87682 8.47401 8.58567 7.19228 GeneID:8776,Genbank:NM_001353992.1,HGNC:HGNC:7449,MIM:300171 myotubularin related protein 1 GO:0004438,GO:0004725,GO:0005737,GO:0005829,GO:0005886,GO:0006661,GO:0042803,GO:0046856,GO:0052629,GO:0060304 phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|cytoplasm|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|protein homodimerization activity|phosphatidylinositol dephosphorylation|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR10 1119.98959480787 1075.26395946226 1164.71523015349 1.08319005757058 0.11528640181778 0.575660026410562 1 6.62194 7.05377 8.85106 6.2249 GeneID:54893,Genbank:XM_011521737.3,HGNC:HGNC:25999 myotubularin related protein 10 GO:0005737,GO:0005829 cytoplasm|cytosol MTMR11 365.992603925728 348.626769885296 383.358437966161 1.09962421443509 0.13701058138946 0.481470278060618 1 2.90446 3.23353 3.61696 3.26354 GeneID:10903,Genbank:NM_001145862.1,HGNC:HGNC:24307 myotubularin related protein 11 GO:0005737,GO:0070062 cytoplasm|extracellular exosome MTMR12 1447.29186378871 1476.02938605292 1418.5543415245 0.961061043180101 -0.0573000261190224 0.693515578576281 1 9.12984 9.53784 9.71371 8.52208 GeneID:54545,Genbank:NM_001294344.1,HGNC:HGNC:18191,MIM:606501 myotubularin related protein 12 GO:0005737,GO:0005829,GO:0006661,GO:0019208,GO:1901998 cytoplasm|cytosol|phosphatidylinositol biosynthetic process|phosphatase regulator activity|toxin transport MTMR14 1374.29970015247 1352.46781717818 1396.13158312676 1.03228451383019 0.0458406549870918 0.777243654750642 1 14.0574 15.3397 14.6793 16.1492 GeneID:64419,Genbank:NM_001077525.2,HGNC:HGNC:26190,MIM:611089 myotubularin related protein 14 GO:0001726,GO:0004438,GO:0004722,GO:0004725,GO:0005829,GO:0006661,GO:0016236,GO:0048471,GO:0052629 ruffle|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|cytosol|phosphatidylinositol biosynthetic process|macroautophagy|perinuclear region of cytoplasm|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity hsa00562,hsa04070,hsa04140 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - animal MTMR2 954.244485576687 887.260871555972 1021.2280995974 1.15098967207524 0.202874888107257 0.36434375191812 1 7.12527 5.74932 8.59891 6.31688 GeneID:8898,Genbank:NM_016156.5,HGNC:HGNC:7450,MIM:603557 myotubularin related protein 2 hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR3 1222.73856078743 1239.23393136242 1206.24319021245 0.9733781166614 -0.0389277543565853 0.782268633384089 1 3.76591 4.02481 4.02496 3.76361 GeneID:8897,Genbank:XM_005261804.3,HGNC:HGNC:7451,MIM:603558 myotubularin related protein 3 GO:0004438,GO:0004722,GO:0004725,GO:0005737,GO:0005829,GO:0006470,GO:0006661,GO:0016020,GO:0016236,GO:0019898,GO:0019903,GO:0042149,GO:0046856,GO:0046872,GO:0052629,GO:0060304,GO:1904562,GO:2000785 phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|cytoplasm|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|membrane|macroautophagy|extrinsic component of membrane|protein phosphatase binding|cellular response to glucose starvation|phosphatidylinositol dephosphorylation|metal ion binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation|phosphatidylinositol 5-phosphate metabolic process|regulation of autophagosome assembly hsa00562,hsa04070,hsa04140 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - animal MTMR4 1695.09848802002 1692.96325298234 1697.23372305771 1.00252248243891 0.00363459073448422 0.978870501968388 1 9.30569 9.30953 10.043 8.86882 GeneID:9110,Genbank:NM_004687.4,HGNC:HGNC:7452,MIM:603559 myotubularin related protein 4 GO:0004438,GO:0004722,GO:0004725,GO:0005615,GO:0005768,GO:0005829,GO:0006470,GO:0006661,GO:0007179,GO:0014894,GO:0019903,GO:0030512,GO:0031901,GO:0046872,GO:0052629,GO:0060304 phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|extracellular space|endosome|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|transforming growth factor beta receptor signaling pathway|response to denervation involved in regulation of muscle adaptation|protein phosphatase binding|negative regulation of transforming growth factor beta receptor signaling pathway|early endosome membrane|metal ion binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation hsa00562,hsa04070,hsa04140 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - animal MTMR6 564.358960110647 584.442081771883 544.275838449412 0.931274210781166 -0.102722067504514 0.559631818505387 1 4.30138 4.18639 4.43934 3.47522 GeneID:9107,Genbank:NM_004685.3,HGNC:HGNC:7453,MIM:603561 myotubularin related protein 6 GO:0004438,GO:0004722,GO:0004725,GO:0005635,GO:0005737,GO:0005829,GO:0006470,GO:0006661,GO:0015269,GO:0046856,GO:0052629,GO:0106018 phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|nuclear envelope|cytoplasm|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|calcium-activated potassium channel activity|phosphatidylinositol dephosphorylation|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3,5-bisphosphate phosphatase activity hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR7 5.20960874356754 4.60274771635603 5.81646977077905 1.26369510762235 0.337648425714058 0.871781482418834 1 0.0236895 0.0283614 0.0398767 0.026545 GeneID:9108,Genbank:XM_017013956.2,HGNC:HGNC:7454,MIM:603562 myotubularin related protein 7 GO:0004438,GO:0004725,GO:0005737,GO:0005829,GO:0006470,GO:0006661,GO:0016020,GO:0046855,GO:0046856,GO:0052629 phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|cytoplasm|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|membrane|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR8 30.3776953341772 26.8284485929612 33.9269420753932 1.26458829543704 0.338667771633025 0.516581484719245 1 0.280867 0.250171 0.453169 0.329386 GeneID:55613,Genbank:NM_017677.3,HGNC:HGNC:16825 myotubularin related protein 8 GO:0004438,GO:0004725,GO:0005635,GO:0005737,GO:0005829,GO:0006661,GO:0010506,GO:0010507,GO:0043234,GO:0046856,GO:0052629,GO:0106018 phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity|nuclear envelope|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|regulation of autophagy|negative regulation of autophagy|protein complex|phosphatidylinositol dephosphorylation|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3,5-bisphosphate phosphatase activity hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system MTMR9 417.651333814764 444.639496046797 390.66317158273 0.878606545428465 -0.186710847651074 0.453400109170041 1 2.47469 2.16831 2.38031 1.69045 GeneID:66036,Genbank:XM_011543830.3,HGNC:HGNC:14596,MIM:606260 myotubularin related protein 9 GO:0004438,GO:0005737,GO:0005829,GO:0006661,GO:0010507,GO:0010922,GO:0019903,GO:0030234,GO:0043234,GO:0050821,GO:0052629,GO:0060304 phosphatidylinositol-3-phosphatase activity|cytoplasm|cytosol|phosphatidylinositol biosynthetic process|negative regulation of autophagy|positive regulation of phosphatase activity|protein phosphatase binding|enzyme regulator activity|protein complex|protein stabilization|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|regulation of phosphatidylinositol dephosphorylation MTNR1A 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0159918 0 0 GeneID:4543,Genbank:XM_011532002.3,HGNC:HGNC:7463,MIM:600665 melatonin receptor 1A hsa04080,hsa04713 Neuroactive ligand-receptor interaction|Circadian entrainment MTO1 490.887939506179 517.495421803319 464.280457209038 0.897168240814881 -0.156549544046149 0.390960330024806 1 5.65632 4.97445 4.9749 4.69251 GeneID:25821,Genbank:NM_133645.2,HGNC:HGNC:19261,MIM:614667 mitochondrial tRNA translation optimization 1 GO:0003723,GO:0005739,GO:0030488,GO:0050660,GO:0070899 RNA binding|mitochondrion|tRNA methylation|flavin adenine dinucleotide binding|mitochondrial tRNA wobble uridine modification MTOR 3308.61717349906 3255.22558846954 3362.00875852859 1.03280361595746 0.0465659567983693 0.738879346572384 1 10.3405 10.4829 11.6824 9.95759 GeneID:2475,Genbank:NM_004958.3,HGNC:HGNC:3942,MIM:601231 mechanistic target of rapamycin kinase hsa01521,hsa01522,hsa04012,hsa04066,hsa04072,hsa04136,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04218,hsa04371,hsa04630,hsa04659,hsa04714,hsa04910,hsa04919,hsa04920,hsa04930,hsa04931,hsa05163,hsa05165,hsa05167,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05212,hsa05214,hsa05215,hsa05221,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|Phospholipase D signaling pathway|Autophagy - other|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Apelin signaling pathway|Jak-STAT signaling pathway|Th17 cell differentiation|Thermogenesis|Insulin signaling pathway|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Glioma|Prostate cancer|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer MTPAP 252.96948459548 266.007633709204 239.931335481756 0.901971616889935 -0.148846059207598 0.554949266415027 1 2.01744 2.1487 2.27371 1.59417 GeneID:55149,Genbank:NM_018109.3,HGNC:HGNC:25532,MIM:613669 mitochondrial poly(A) polymerase GO:0000287,GO:0002134,GO:0003723,GO:0004652,GO:0005524,GO:0005739,GO:0006351,GO:0006378,GO:0030145,GO:0042802,GO:0042803,GO:0043231,GO:0071044 magnesium ion binding|UTP binding|RNA binding|polynucleotide adenylyltransferase activity|ATP binding|mitochondrion|transcription, DNA-templated|mRNA polyadenylation|manganese ion binding|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|histone mRNA catabolic process MTR 554.633197491648 585.778025808808 523.488369174489 0.893663377781518 -0.16219659083786 0.51903900242621 1 1.83227 1.8329 2.0063 1.33402 GeneID:4548,Genbank:XM_011544194.3,HGNC:HGNC:7468,MIM:156570 5-methyltetrahydrofolate-homocysteine methyltransferase hsa00270,hsa00450,hsa00670 Cysteine and methionine metabolism|Selenocompound metabolism|One carbon pool by folate MTREX 597.544566322898 633.379544381009 561.709588264788 0.886845167716518 -0.173245845226579 0.544876390126703 1 6.2414 4.58818 5.22736 4.34907 GeneID:23517,Genbank:NM_015360.4,HGNC:HGNC:18734 Mtr4 exosome RNA helicase GO:0000398,GO:0000460,GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0006401,GO:0071013 mRNA splicing, via spliceosome|maturation of 5.8S rRNA|RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|nucleolus|rRNA processing|RNA catabolic process|catalytic step 2 spliceosome hsa03018 RNA degradation MTRF1 98.2837502714702 84.6176394034982 111.949861139442 1.32300855860101 0.403822394504947 0.19019392018325 1 0.317724 0.282078 0.453687 0.436126 GeneID:9617,Genbank:NM_001354074.1,HGNC:HGNC:7469,MIM:604601 mitochondrial translation release factor 1 GO:0003747,GO:0005739,GO:0006449 translation release factor activity|mitochondrion|regulation of translational termination MTRF1L 641.68294169023 660.594237173159 622.7716462073 0.942744594431053 -0.0850611217133392 0.613307661112542 1 4.45882 4.98831 4.79781 4.06384 GeneID:54516,Genbank:NM_001301871.1,HGNC:HGNC:21051,MIM:613542 mitochondrial translational release factor 1 like GO:0003747,GO:0005739,GO:0005759,GO:0070126 translation release factor activity|mitochondrion|mitochondrial matrix|mitochondrial translational termination MTRNR2L1 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0216152 0 0.020536 0 GeneID:100462977,Genbank:NM_001190452.1,HGNC:HGNC:37155,MIM:616985 MT-RNR2 like 1 GO:0005576,GO:0005737 extracellular region|cytoplasm MTRNR2L10 6.81628875796407 6.85119097229513 6.78138654363301 0.989811343904382 -0.0147745183312502 1 1 0.410377 0.11809 0.117246 0.40327 GeneID:100463488,Genbank:NM_001190708.1,HGNC:HGNC:37167 MT-RNR2 like 10 MTRNR2L2 15.4418230031493 15.3745099043101 15.5091361019885 1.00875645458075 0.012577904692004 1 1 0.419446 0.492158 0.517542 0.427468 GeneID:100462981,Genbank:NM_001190470.1,HGNC:HGNC:37156 MT-RNR2 like 2 GO:0005576,GO:0005737 extracellular region|cytoplasm MTRNR2L8 2.20671213250964 0.538097676642304 3.87532658837698 7.20190173010739 2.84837791409998 0.282996000360632 1 0 0 0.0265423 0.0993662 GeneID:100463486,Genbank:NM_001190702.1,HGNC:HGNC:37165 MT-RNR2 like 8 GO:0005576,GO:0005737 extracellular region|cytoplasm MTRNR2L9 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0989109 0 GeneID:100463487,Genbank:NM_001190706.1,HGNC:HGNC:37166 MT-RNR2 like 9 GO:0005576,GO:0005737 extracellular region|cytoplasm MTRR 799.108186123318 887.204053627034 711.012318619602 0.80140787873192 -0.319391401750051 0.0463398580558041 0.79332376136203 7.93084 7.02355 6.73831 5.41297 GeneID:4552,Genbank:XM_024446064.1,HGNC:HGNC:7473,MIM:602568 5-methyltetrahydrofolate-homocysteine methyltransferase reductase MTSS1 1.48335117242078 1.02816907859967 1.93853326624189 1.88542264749112 0.914887962799843 0.868258168018795 1 0 0 0.00465588 0.00434082 GeneID:9788,Genbank:NM_014751.5,HGNC:HGNC:20443,MIM:608486 MTSS1, I-BAR domain containing GO:0001726,GO:0003785,GO:0005102,GO:0005737,GO:0006928,GO:0007009,GO:0007155,GO:0007169,GO:0015629,GO:0030035,GO:0030036,GO:0030139,GO:0042802,GO:0050680,GO:0061333,GO:0071498,GO:0072102,GO:0072160,GO:2001013 ruffle|actin monomer binding|receptor binding|cytoplasm|movement of cell or subcellular component|plasma membrane organization|cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway|actin cytoskeleton|microspike assembly|actin cytoskeleton organization|endocytic vesicle|identical protein binding|negative regulation of epithelial cell proliferation|renal tubule morphogenesis|cellular response to fluid shear stress|glomerulus morphogenesis|nephron tubule epithelial cell differentiation|epithelial cell proliferation involved in renal tubule morphogenesis MTSS1L 3470.34081719013 2896.0320211527 4044.64961322755 1.39661771129784 0.481937173581279 0.000427199666816836 0.0573245553216597 17.7188 19.1809 26.8836 26.3405 GeneID:92154,Genbank:NM_138383.2,HGNC:HGNC:25094,MIM:616951 MTSS1L, I-BAR domain containing GO:0003785,GO:0005096,GO:0005546,GO:0007009,GO:0030027,GO:0030864,GO:0032587,GO:0036120,GO:0048365,GO:0090630,GO:0097178,GO:0097581 actin monomer binding|GTPase activator activity|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane organization|lamellipodium|cortical actin cytoskeleton|ruffle membrane|cellular response to platelet-derived growth factor stimulus|Rac GTPase binding|activation of GTPase activity|ruffle assembly|lamellipodium organization MTTP 21.7672787535777 20.7554866707331 22.7790708364223 1.09749634869042 0.134216140002103 0.840198396418163 1 0.193966 0.111214 0.214443 0.173456 GeneID:4547,Genbank:NM_000253.3,HGNC:HGNC:7467,MIM:157147 microsomal triglyceride transfer protein GO:0005319,GO:0005548,GO:0005783,GO:0005788,GO:0006629,GO:0008289,GO:0009306,GO:0015914,GO:0034197,GO:0034377,GO:0034378,GO:0034379,GO:0043235,GO:0046982 lipid transporter activity|phospholipid transporter activity|endoplasmic reticulum|endoplasmic reticulum lumen|lipid metabolic process|lipid binding|protein secretion|phospholipid transport|triglyceride transport|plasma lipoprotein particle assembly|chylomicron assembly|very-low-density lipoprotein particle assembly|receptor complex|protein heterodimerization activity hsa04975 Fat digestion and absorption MTURN 369.875912802947 397.632893080177 342.118932525717 0.860388912686692 -0.216939161147994 0.247174477285911 1 2.82248 2.94805 2.32792 2.7 GeneID:222166,Genbank:NM_152793.2,HGNC:HGNC:25457 maturin, neural progenitor differentiation regulator homolog GO:0007275 multicellular organism development MTUS1 322.172804868014 310.372791568152 333.972818167876 1.07603767869111 0.105728596397408 0.733970697277472 1 0.790204 0.790911 1.02297 0.647967 GeneID:57509,Genbank:XM_017013700.1,HGNC:HGNC:29789,MIM:609589 microtubule associated scaffold protein 1 MTUS2 9.83472511343954 8.52331893201493 11.1461312948641 1.30772195476548 0.387055830497941 0.745520573176018 1 0.00732378 0.0338849 0.0346927 0.0356222 GeneID:23281,Genbank:XM_011535019.3,HGNC:HGNC:20595 microtubule associated scaffold protein 2 GO:0005634,GO:0005737,GO:0005874,GO:0008017,GO:0042803 nucleus|cytoplasm|microtubule|microtubule binding|protein homodimerization activity MTX1 376.673977706035 366.135070186814 387.212885225256 1.05756841328444 0.080750993192721 0.706150025051539 1 9.06241 10.7026 9.92762 10.1952 GeneID:4580,Genbank:NM_002455.4,HGNC:HGNC:7504,MIM:600605 metaxin 1 GO:0005741,GO:0006626,GO:0016021 mitochondrial outer membrane|protein targeting to mitochondrion|integral component of membrane MTX2 912.658706493907 955.390605083154 869.92680790466 0.910545700655016 -0.135196666423579 0.387951627642876 1 21.9939 22.1095 20.9297 19.2575 GeneID:10651,Genbank:NM_001006635.2,HGNC:HGNC:7506,MIM:608555 metaxin 2 GO:0005730,GO:0005739,GO:0005741,GO:0006626,GO:0006839 nucleolus|mitochondrion|mitochondrial outer membrane|protein targeting to mitochondrion|mitochondrial transport MTX3 283.887426438789 331.723193844466 236.051659033112 0.711592265519393 -0.490877265223068 0.149577576911145 1 2.09773 1.57821 1.64026 1.09886 GeneID:345778,Genbank:NM_001167741.1,HGNC:HGNC:24812 metaxin 3 GO:0005741,GO:0006626 mitochondrial outer membrane|protein targeting to mitochondrion MUC1 83.077249774472 64.3806330991915 101.773866449752 1.5808149368918 0.6606684839165 0.0390673295143921 0.753859521009372 1.37512 1.16806 1.9114 1.89703 GeneID:4582,Genbank:NM_001204290.1,HGNC:HGNC:7508,MIM:158340 mucin 1, cell surface associated MUC12 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00139382 0 0 GeneID:10071,Genbank:NM_001164462.1,HGNC:HGNC:7510,MIM:604609 mucin 12, cell surface associated MUC16 1.27070322989325 2.05633815719933 0.48506830258717 0.235889365223771 -2.08381771694066 0.63179572723844 1 0.00127036 0.00116109 0.000599275 0 GeneID:94025,Genbank:XM_017027500.1,HGNC:HGNC:15582,MIM:606154 mucin 16, cell surface associated MUC20 10.4864945537225 12.7320477957835 8.24094131166151 0.647259690180451 -0.627583435888845 0.497868373922074 1 0.138374 0.15864 0.056305 0.0663402 GeneID:200958,Genbank:NM_001282506.1,HGNC:HGNC:23282,MIM:610360 mucin 20, cell surface associated MUC22 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.00840915 0 0 GeneID:100507679,Genbank:NM_001198815.1,HGNC:HGNC:39755,MIM:613917 mucin 22 MUC4 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.00187885 GeneID:4585,Genbank:NM_138297.4,HGNC:HGNC:7514,MIM:158372 mucin 4, cell surface associated MUC5AC 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:4586,Genbank:NM_001304359.1,HGNC:HGNC:7515,MIM:158373 mucin 5AC, oligomeric mucus/gel-forming hsa04657 IL-17 signaling pathway MUC6 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0109592 0 GeneID:4588,Genbank:NM_005961.2,HGNC:HGNC:7517,MIM:158374 mucin 6, oligomeric mucus/gel-forming MUL1 1386.67680758051 1315.57920886329 1457.77440629774 1.10808562226923 0.148069363382227 0.331088466163949 1 16.6284 19.1863 20.9832 19.4457 GeneID:79594,Genbank:XM_011542137.2,HGNC:HGNC:25762,MIM:612037 mitochondrial E3 ubiquitin protein ligase 1 GO:0000266,GO:0004842,GO:0004871,GO:0005739,GO:0005777,GO:0006915,GO:0006919,GO:0007257,GO:0010637,GO:0010821,GO:0016020,GO:0016567,GO:0019789,GO:0030308,GO:0030424,GO:0031307,GO:0031625,GO:0031648,GO:0033235,GO:0042802,GO:0043025,GO:0043123,GO:0045824,GO:0046872,GO:0050689,GO:0050821,GO:0051646,GO:0051881,GO:0051898,GO:0060339,GO:0071360,GO:0071650,GO:0090141,GO:1901028,GO:1903861,GO:1904925 mitochondrial fission|ubiquitin-protein transferase activity|signal transducer activity|mitochondrion|peroxisome|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|activation of JUN kinase activity|negative regulation of mitochondrial fusion|regulation of mitochondrion organization|membrane|protein ubiquitination|SUMO transferase activity|negative regulation of cell growth|axon|integral component of mitochondrial outer membrane|ubiquitin protein ligase binding|protein destabilization|positive regulation of protein sumoylation|identical protein binding|neuronal cell body|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of innate immune response|metal ion binding|negative regulation of defense response to virus by host|protein stabilization|mitochondrion localization|regulation of mitochondrial membrane potential|negative regulation of protein kinase B signaling|negative regulation of type I interferon-mediated signaling pathway|cellular response to exogenous dsRNA|negative regulation of chemokine (C-C motif) ligand 5 production|positive regulation of mitochondrial fission|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of dendrite extension|positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization MUM1 1039.90605421402 1035.92499413758 1043.88711429045 1.00768600062547 0.0110461587660267 0.95503016863708 1 6.68666 7.12694 7.08082 6.93602 GeneID:84939,Genbank:XM_024451746.1,HGNC:HGNC:29641 melanoma associated antigen (mutated) 1 GO:0005634,GO:0005829,GO:0006281,GO:0006325,GO:0031491 nucleus|cytosol|DNA repair|chromatin organization|nucleosome binding MUM1L1 11.1995226955194 9.7916193840393 12.6074260069994 1.28757312886876 0.364654373779493 0.768747936658806 1 0.0857149 0.0661996 0.165267 0.0384514 GeneID:139221,Genbank:XM_011530857.1,HGNC:HGNC:26583 MUM1 like 1 GO:0070062 extracellular exosome MUS81 713.38053228836 649.419664478364 777.341400098356 1.19697853732646 0.259397283968735 0.113754060061078 1 10.1264 10.4734 12.6821 12.5146 GeneID:80198,Genbank:XM_011545269.1,HGNC:HGNC:29814,MIM:606591 MUS81 structure-specific endonuclease subunit GO:0000712,GO:0000727,GO:0000737,GO:0003677,GO:0004520,GO:0005634,GO:0005654,GO:0005730,GO:0006281,GO:0007095,GO:0031297,GO:0031573,GO:0036297,GO:0046872,GO:0048257,GO:0048476,GO:0072429 resolution of meiotic recombination intermediates|double-strand break repair via break-induced replication|DNA catabolic process, endonucleolytic|DNA binding|endodeoxyribonuclease activity|nucleus|nucleoplasm|nucleolus|DNA repair|mitotic G2 DNA damage checkpoint|replication fork processing|intra-S DNA damage checkpoint|interstrand cross-link repair|metal ion binding|3'-flap endonuclease activity|Holliday junction resolvase complex|response to intra-S DNA damage checkpoint signaling hsa03440,hsa03460 Homologous recombination|Fanconi anemia pathway MUSK 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0.0100364 0 0 GeneID:4593,Genbank:XM_005251994.3,HGNC:HGNC:7525,MIM:601296 muscle associated receptor tyrosine kinase MUSTN1 4.55785220947939 5.23689794236822 3.87880647659057 0.740668716342504 -0.433099691573259 0.850258506421964 1 0.592849 0.644302 0.431312 0.452489 GeneID:389125,Genbank:NM_205853.3,HGNC:HGNC:22144,MIM:617195 musculoskeletal, embryonic nuclear protein 1 GO:0002062,GO:0005634,GO:0035988,GO:0042246 chondrocyte differentiation|nucleus|chondrocyte proliferation|tissue regeneration MUT 1274.97442618317 1231.69751288686 1318.25133947947 1.07027198292359 0.0979774681712638 0.481498833547562 1 12.9057 11.1862 13.9619 11.8925 GeneID:4594,Genbank:NM_000255.3,HGNC:HGNC:7526,MIM:609058 methylmalonyl-CoA mutase hsa00280,hsa00630,hsa00640 Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism MUTYH 303.931009239078 308.374288340746 299.48773013741 0.971182557887199 -0.0421855833798515 0.832350586153151 1 2.11992 2.36239 2.22113 2.32941 GeneID:4595,Genbank:NM_001350651.1,HGNC:HGNC:7527,MIM:604933 mutY DNA glycosylase hsa03410 Base excision repair MVB12A 1058.28305908928 1018.40790218181 1098.15821599675 1.07830881284806 0.10877040532842 0.484944673034095 1 26.0306 26.0762 28.7797 28.5463 GeneID:93343,Genbank:NM_001304547.1,HGNC:HGNC:25153 multivesicular body subunit 12A GO:0000813,GO:0005654,GO:0005794,GO:0005813,GO:0005829,GO:0008289,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0017124,GO:0019058,GO:0019075,GO:0031902,GO:0031982,GO:0036258,GO:0039702,GO:0042058,GO:0043130,GO:0043162,GO:0043657,GO:0048524,GO:0070062,GO:0075733,GO:1903772 ESCRT I complex|nucleoplasm|Golgi apparatus|centrosome|cytosol|lipid binding|endosome membrane|protein transport|endosomal transport|macroautophagy|SH3 domain binding|viral life cycle|virus maturation|late endosome membrane|vesicle|multivesicular body assembly|viral budding via host ESCRT complex|regulation of epidermal growth factor receptor signaling pathway|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|host cell|positive regulation of viral process|extracellular exosome|intracellular transport of virus|regulation of viral budding via host ESCRT complex hsa04144 Endocytosis MVB12B 147.375109003237 138.216701659628 156.533516346845 1.13252244097334 0.179539637609423 0.48183538264368 1 0.53977 0.461787 0.512296 0.546181 GeneID:89853,Genbank:NM_033446.2,HGNC:HGNC:23368 multivesicular body subunit 12B GO:0000813,GO:0005634,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0008289,GO:0010008,GO:0015031,GO:0016197,GO:0019058,GO:0019075,GO:0031902,GO:0031982,GO:0042058,GO:0043162,GO:0043657,GO:0048524,GO:0070062,GO:0075733 ESCRT I complex|nucleus|early endosome|late endosome|cytosol|plasma membrane|lipid binding|endosome membrane|protein transport|endosomal transport|viral life cycle|virus maturation|late endosome membrane|vesicle|regulation of epidermal growth factor receptor signaling pathway|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|host cell|positive regulation of viral process|extracellular exosome|intracellular transport of virus hsa04144 Endocytosis MVD 532.435630681348 478.493657402287 586.377603960408 1.22546578181165 0.293330200973535 0.0936443382297097 0.991936323470258 6.60191 7.41429 8.52376 8.96287 GeneID:4597,Genbank:XM_011523086.2,HGNC:HGNC:7529,MIM:603236 mevalonate diphosphate decarboxylase GO:0004163,GO:0005524,GO:0005829,GO:0006489,GO:0006695,GO:0008284,GO:0008299,GO:0019287,GO:0030544,GO:0042803,GO:0045540 diphosphomevalonate decarboxylase activity|ATP binding|cytosol|dolichyl diphosphate biosynthetic process|cholesterol biosynthetic process|positive regulation of cell proliferation|isoprenoid biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway|Hsp70 protein binding|protein homodimerization activity|regulation of cholesterol biosynthetic process hsa00900 Terpenoid backbone biosynthesis MVK 390.56151698421 369.680222859246 411.442811109173 1.1129694954383 0.154414051455264 0.416189048211253 1 3.6558 3.85187 4.37257 4.38248 GeneID:4598,Genbank:XM_024448982.1,HGNC:HGNC:7530,MIM:251170 mevalonate kinase hsa00900,hsa04146 Terpenoid backbone biosynthesis|Peroxisome MVP 4119.59526585926 4042.45914410069 4196.73138761783 1.03816296912791 0.05403293338531 0.698796144325755 1 52.3541 53.2832 54.7214 56.6604 GeneID:9961,Genbank:NM_017458.3,HGNC:HGNC:7531,MIM:605088 major vault protein MX1 1023.66007849343 357.08244523241 1690.23771175446 4.7334662745864 2.24289704312008 0.346810822921677 1 1.70461 1.72031 16.2672 1.16363 GeneID:4599,Genbank:XM_011529568.2,HGNC:HGNC:7532,MIM:147150 MX dynamin like GTPase 1 GO:0000266,GO:0003374,GO:0003924,GO:0005525,GO:0005737,GO:0005789,GO:0005829,GO:0006915,GO:0006952,GO:0007165,GO:0008017,GO:0009615,GO:0031965,GO:0031966,GO:0034340,GO:0042802,GO:0045071,GO:0045087,GO:0048471,GO:0051607,GO:0060337,GO:0061025 mitochondrial fission|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|GTP binding|cytoplasm|endoplasmic reticulum membrane|cytosol|apoptotic process|defense response|signal transduction|microtubule binding|response to virus|nuclear membrane|mitochondrial membrane|response to type I interferon|identical protein binding|negative regulation of viral genome replication|innate immune response|perinuclear region of cytoplasm|defense response to virus|type I interferon signaling pathway|membrane fusion hsa05162,hsa05164,hsa05165 Measles|Influenza A|Human papillomavirus infection MX2 177.880273893115 49.6981083506865 306.062439435543 6.15843237484743 2.62256316052176 0.364469473618566 1 0.386353 0.405426 5.15619 0.153014 GeneID:4600,Genbank:XM_011529573.2,HGNC:HGNC:7533,MIM:147890 MX dynamin like GTPase 2 GO:0000266,GO:0003374,GO:0003924,GO:0005525,GO:0005634,GO:0005643,GO:0005737,GO:0005829,GO:0006952,GO:0008017,GO:0009615,GO:0015031,GO:0031966,GO:0035455,GO:0045087,GO:0046822,GO:0051028,GO:0051607,GO:0051726,GO:0060337,GO:0061025 mitochondrial fission|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|GTP binding|nucleus|nuclear pore|cytoplasm|cytosol|defense response|microtubule binding|response to virus|protein transport|mitochondrial membrane|response to interferon-alpha|innate immune response|regulation of nucleocytoplasmic transport|mRNA transport|defense response to virus|regulation of cell cycle|type I interferon signaling pathway|membrane fusion MXD1 147.379448643641 166.803522106571 127.955375180712 0.767102358300093 -0.382508998307516 0.139654089675019 1 1.46741 1.3203 1.22561 0.936326 GeneID:4084,Genbank:NM_002357.3,HGNC:HGNC:6761,MIM:600021 MAX dimerization protein 1 GO:0000122,GO:0000790,GO:0000978,GO:0001078,GO:0003700,GO:0003712,GO:0003714,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006351,GO:0007275,GO:0008283,GO:0046983 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|transcription cofactor activity|transcription corepressor activity|nucleus|nucleoplasm|mitochondrion|cytosol|transcription, DNA-templated|multicellular organism development|cell proliferation|protein dimerization activity MXD3 1056.38860196773 996.37430640394 1116.40289753153 1.12046536161775 0.164098049656229 0.588388116160704 1 8.19612 8.895 9.0512 11.3398 GeneID:83463,Genbank:NM_001142935.1,HGNC:HGNC:14008,MIM:609450 MAX dimerization protein 3 GO:0000977,GO:0001227,GO:0006351,GO:0046983,GO:0090575 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|transcription, DNA-templated|protein dimerization activity|RNA polymerase II transcription factor complex MXD4 662.467409558518 615.519510849899 709.415308267137 1.1525472316671 0.204825873861259 0.445752031345288 1 4.1678 4.98737 4.80549 5.98601 GeneID:10608,Genbank:XM_011513388.3,HGNC:HGNC:13906 MAX dimerization protein 4 GO:0000122,GO:0003677,GO:0003714,GO:0005634,GO:0006351,GO:0008285,GO:0046983 negative regulation of transcription from RNA polymerase II promoter|DNA binding|transcription corepressor activity|nucleus|transcription, DNA-templated|negative regulation of cell proliferation|protein dimerization activity MXI1 307.708720168167 311.083377033319 304.334063303015 0.978303843186128 -0.0316454855599693 0.905847558154568 1 3.80665 3.30056 3.42729 3.5914 GeneID:4601,Genbank:NM_130439.3,HGNC:HGNC:7534,MIM:600020 MAX interactor 1, dimerization protein MXRA7 5293.15816070081 5007.39244554021 5578.92387586141 1.11413753496198 0.155927337489464 0.245966788126005 1 26.7049 28.6912 31.0529 31.3323 GeneID:439921,Genbank:NM_001008528.2,HGNC:HGNC:7541 matrix remodeling associated 7 GO:0016021,GO:0031012 integral component of membrane|extracellular matrix MXRA8 11.076945864463 10.5218221594214 11.6320695695047 1.10551854928371 0.144723232060616 0.8871704756618 1 0.0898734 0.0382276 0.0824815 0.0677471 GeneID:54587,Genbank:NM_001282582.1,HGNC:HGNC:7542,MIM:617293 matrix remodeling associated 8 GO:0005788,GO:0009986,GO:0016021,GO:0043687,GO:0044267,GO:0060857,GO:0070062 endoplasmic reticulum lumen|cell surface|integral component of membrane|post-translational protein modification|cellular protein metabolic process|establishment of glial blood-brain barrier|extracellular exosome MYADM 2133.1730269 2305.58055304007 1960.76550075993 0.850443285607402 -0.233713066289882 0.0930908464145316 0.988657766036134 27.4498 27.264 23.5315 23.9556 GeneID:91663,Genbank:NM_001290193.1,HGNC:HGNC:7544,MIM:609959 myeloid associated differentiation marker GO:0001726,GO:0001933,GO:0005886,GO:0005911,GO:0010629,GO:0016021,GO:0030335,GO:0030837,GO:0030864,GO:0031579,GO:0034115,GO:0045121,GO:0061028,GO:0070062,GO:0072659,GO:0090038,GO:1900026 ruffle|negative regulation of protein phosphorylation|plasma membrane|cell-cell junction|negative regulation of gene expression|integral component of membrane|positive regulation of cell migration|negative regulation of actin filament polymerization|cortical actin cytoskeleton|membrane raft organization|negative regulation of heterotypic cell-cell adhesion|membrane raft|establishment of endothelial barrier|extracellular exosome|protein localization to plasma membrane|negative regulation of protein kinase C signaling|positive regulation of substrate adhesion-dependent cell spreading MYADML2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0200008 0 GeneID:255275,Genbank:NM_001145113.2,HGNC:HGNC:34548 myeloid associated differentiation marker like 2 GO:0005737,GO:0016021 cytoplasm|integral component of membrane MYB 50.0802613094469 42.0010447434236 58.1594778754702 1.38471502865596 0.469589103316752 0.234909684758886 1 0.437977 0.312311 0.571534 0.418308 GeneID:4602,Genbank:NM_001130173.1,HGNC:HGNC:7545,MIM:189990 MYB proto-oncogene, transcription factor hsa04151,hsa05166 PI3K-Akt signaling pathway|Human T-cell leukemia virus 1 infection MYBBP1A 2909.69986470881 3238.24964519298 2581.15008422464 0.797081870465495 -0.327200179895649 0.0150613894536214 0.511066130273729 24.0193 26.264 21.0657 19.6817 GeneID:10514,Genbank:NM_001105538.1,HGNC:HGNC:7546,MIM:604885 MYB binding protein 1a MYBL1 380.665964206136 385.178177276541 376.153751135732 0.976570775103051 -0.0342034904167706 0.959683554250109 1 2.52848 1.80269 2.72528 1.55399 GeneID:4603,Genbank:NM_001294282.1,HGNC:HGNC:7547,MIM:159405 MYB proto-oncogene like 1 MYBL2 3542.53687700763 3298.64104649075 3786.43270752451 1.14787655102779 0.198967494978278 0.146882668817156 1 36.1823 38.0089 44.8165 42.0195 GeneID:4605,Genbank:NM_002466.3,HGNC:HGNC:7548,MIM:601415 MYB proto-oncogene like 2 hsa04218,hsa05166 Cellular senescence|Human T-cell leukemia virus 1 infection MYBPC1 2.96963888055335 2.54640955915669 3.39286820195 1.33241260807772 0.414040910824943 0.922281812887816 1 0.0151759 0.0143083 0.0145395 0.0202309 GeneID:4604,Genbank:XM_017019320.1,HGNC:HGNC:7549,MIM:160794 myosin binding protein C, slow type GO:0005829,GO:0005859,GO:0006941,GO:0007015,GO:0007155,GO:0008307,GO:0030016,GO:0030018,GO:0030049,GO:0031430,GO:0031432,GO:0032982,GO:0045214,GO:0051015,GO:0051371,GO:0071688,GO:0097493,GO:1903955 cytosol|muscle myosin complex|striated muscle contraction|actin filament organization|cell adhesion|structural constituent of muscle|myofibril|Z disc|muscle filament sliding|M band|titin binding|myosin filament|sarcomere organization|actin filament binding|muscle alpha-actinin binding|striated muscle myosin thick filament assembly|structural molecule activity conferring elasticity|positive regulation of protein targeting to mitochondrion MYBPHL 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:343263,Genbank:XM_017001175.1,HGNC:HGNC:30434 myosin binding protein H like GO:0005859,GO:0006941,GO:0007015,GO:0008307,GO:0030018,GO:0031430,GO:0045214,GO:0051015,GO:0051371,GO:0071688,GO:0097493 muscle myosin complex|striated muscle contraction|actin filament organization|structural constituent of muscle|Z disc|M band|sarcomere organization|actin filament binding|muscle alpha-actinin binding|striated muscle myosin thick filament assembly|structural molecule activity conferring elasticity MYC 2007.66447079563 2262.89834879681 1752.43059279445 0.77441860953508 -0.368814473419756 0.00814155696789123 0.354981226562783 19.9719 21.9799 16.8991 16.0051 GeneID:4609,Genbank:NM_002467.5,HGNC:HGNC:7553,MIM:190080 MYC proto-oncogene, bHLH transcription factor hsa04010,hsa04012,hsa04110,hsa04151,hsa04218,hsa04310,hsa04350,hsa04390,hsa04550,hsa04630,hsa04919,hsa05161,hsa05163,hsa05166,hsa05167,hsa05169,hsa05200,hsa05202,hsa05205,hsa05206,hsa05210,hsa05213,hsa05216,hsa05219,hsa05220,hsa05221,hsa05222,hsa05224,hsa05225,hsa05226,hsa05230 MAPK signaling pathway|ErbB signaling pathway|Cell cycle|PI3K-Akt signaling pathway|Cellular senescence|Wnt signaling pathway|TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Jak-STAT signaling pathway|Thyroid hormone signaling pathway|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Endometrial cancer|Thyroid cancer|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer MYCBP 733.670005409367 798.090544712513 669.249466106222 0.838563331617089 -0.254008348951557 0.114341095718464 1 13.8561 14.8934 11.9824 12.2621 GeneID:26292,Genbank:NM_012333.4,HGNC:HGNC:7554,MIM:606535 MYC binding protein GO:0003713,GO:0005634,GO:0005737,GO:0005739,GO:0006351,GO:0006355,GO:0007283 transcription coactivator activity|nucleus|cytoplasm|mitochondrion|transcription, DNA-templated|regulation of transcription, DNA-templated|spermatogenesis MYCBP2 488.257537727757 496.595856308531 479.919219146983 0.96641809038538 -0.0492806341554536 0.923170088467582 1 1.03015 0.901971 1.24366 0.597463 GeneID:23077,Genbank:XM_017020465.2,HGNC:HGNC:23386,MIM:610392 MYC binding protein 2, E3 ubiquitin protein ligase GO:0005634,GO:0006351,GO:0006355,GO:0016020,GO:0016567,GO:0016740,GO:0043231,GO:0046872 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|membrane|protein ubiquitination|transferase activity|intracellular membrane-bounded organelle|metal ion binding MYCBPAP 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.013308 GeneID:84073,Genbank:NM_032133.4,HGNC:HGNC:19677,MIM:609835 MYCBP associated protein GO:0005737,GO:0007268,GO:0007275,GO:0007283,GO:0016020,GO:0030154 cytoplasm|chemical synaptic transmission|multicellular organism development|spermatogenesis|membrane|cell differentiation MYCL 33.5505304258047 26.3962121207967 40.7048487308126 1.54207158756474 0.624869741016462 0.217962885400333 1 0.179384 0.279776 0.347141 0.402996 GeneID:4610,Genbank:NM_001033082.2,HGNC:HGNC:7555,MIM:164850 MYCL proto-oncogene, bHLH transcription factor GO:0003677,GO:0003700,GO:0005634,GO:0045607,GO:0046983 DNA binding|DNA binding transcription factor activity|nucleus|regulation of inner ear auditory receptor cell differentiation|protein dimerization activity MYCN 4.66813954518674 3.03648096111406 6.29979812925943 2.07470364870923 1.05290527618419 0.502159996744781 1 0.0370703 0.0646782 0.102961 0.0801786 GeneID:4613,Genbank:NM_001293228.1,HGNC:HGNC:7559,MIM:164840 MYCN proto-oncogene, bHLH transcription factor hsa05202 Transcriptional misregulation in cancer MYCT1 2.47619595685749 1.07619535328461 3.87619656043037 3.60175924250184 1.84870174835767 0.420368655579507 1 0.0173595 0 0.0251472 0.0390734 GeneID:80177,Genbank:NM_025107.2,HGNC:HGNC:23172,MIM:616805 MYC target 1 GO:0005654,GO:0043231 nucleoplasm|intracellular membrane-bounded organelle MYD88 1806.51005875507 1624.69147463281 1988.32864287732 1.22381921363051 0.29139045438488 0.374143221892058 1 15.0438 15.4725 23.316 14.7829 GeneID:4615,Genbank:XM_006713170.2,HGNC:HGNC:7562,MIM:602170 myeloid differentiation primary response 88 GO:0002755,GO:0005737,GO:0006954,GO:0043123,GO:0045087,GO:0050830,GO:0070976 MyD88-dependent toll-like receptor signaling pathway|cytoplasm|inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|defense response to Gram-positive bacterium|TIR domain binding hsa04010,hsa04064,hsa04620,hsa04621,hsa05132,hsa05133,hsa05134,hsa05140,hsa05142,hsa05143,hsa05144,hsa05145,hsa05152,hsa05161,hsa05162,hsa05164,hsa05168,hsa05169,hsa05170 MAPK signaling pathway|NF-kappa B signaling pathway|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Salmonella infection|Pertussis|Legionellosis|Leishmaniasis|Chagas disease (American trypanosomiasis)|African trypanosomiasis|Malaria|Toxoplasmosis|Tuberculosis|Hepatitis B|Measles|Influenza A|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection MYDGF 3927.90940084418 3830.68675687534 4025.13204481302 1.0507599029309 0.0714330532940532 0.615713382069133 1 74.4316 80.0301 81.3626 86.1049 GeneID:56005,Genbank:NM_019107.3,HGNC:HGNC:16948,MIM:606746 myeloid derived growth factor GO:0001525,GO:0001934,GO:0001938,GO:0005615,GO:0005788,GO:0005793,GO:0006915,GO:0014068,GO:0036498,GO:0043066,GO:0043410,GO:0045766,GO:0045944,GO:0051897,GO:0070062 angiogenesis|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|extracellular space|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|apoptotic process|positive regulation of phosphatidylinositol 3-kinase signaling|IRE1-mediated unfolded protein response|negative regulation of apoptotic process|positive regulation of MAPK cascade|positive regulation of angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of protein kinase B signaling|extracellular exosome MYEF2 1359.64826858491 1430.06751847255 1289.22901869726 0.901516188602257 -0.149574696400573 0.349397108997934 1 5.04101 4.75619 4.87428 3.66101 GeneID:50804,Genbank:XM_017022287.1,HGNC:HGNC:17940 myelin expression factor 2 GO:0000981,GO:0003697,GO:0003723,GO:0005634,GO:0006351,GO:0014902,GO:0030182 RNA polymerase II transcription factor activity, sequence-specific DNA binding|single-stranded DNA binding|RNA binding|nucleus|transcription, DNA-templated|myotube differentiation|neuron differentiation MYEOV 490.051523649352 514.36390529369 465.739142005013 0.905466221894181 -0.14326727195013 0.409581290136922 1 9.04076 9.38531 8.83272 8.01279 GeneID:26579,Genbank:NM_001293294.1,HGNC:HGNC:7563,MIM:605625 myeloma overexpressed MYH10 1403.20051488556 1441.51266550695 1364.88836426417 0.946844517515332 -0.0788005564439544 0.691039572513805 1 5.02213 4.59358 5.33844 3.66518 GeneID:4628,Genbank:NM_005964.3,HGNC:HGNC:7568,MIM:160776 myosin heavy chain 10 GO:0000146,GO:0000281,GO:0001725,GO:0003779,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0005938,GO:0007155,GO:0008360,GO:0016459,GO:0016460,GO:0016887,GO:0030027,GO:0030048,GO:0030496,GO:0030898,GO:0031032,GO:0032154,GO:0035613,GO:0042641,GO:0043531,GO:0048027,GO:0050714,GO:0051015,GO:0070062,GO:0097513 microfilament motor activity|mitotic cytokinesis|stress fiber|actin binding|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|polysome|cell cortex|cell adhesion|regulation of cell shape|myosin complex|myosin II complex|ATPase activity|lamellipodium|actin filament-based movement|midbody|actin-dependent ATPase activity|actomyosin structure organization|cleavage furrow|RNA stem-loop binding|actomyosin|ADP binding|mRNA 5'-UTR binding|positive regulation of protein secretion|actin filament binding|extracellular exosome|myosin II filament hsa04530,hsa04810,hsa05132 Tight junction|Regulation of actin cytoskeleton|Salmonella infection MYH11 12.9306293716804 12.7800740704684 13.0811846728924 1.0235609434471 0.0335970038672947 1 1 0.0131114 0.00788085 0.0246178 0.0229386 GeneID:4629,Genbank:NM_002474.2,HGNC:HGNC:7569,MIM:160745 myosin heavy chain 11 hsa04270,hsa04530 Vascular smooth muscle contraction|Tight junction MYH14 23.2740009390229 21.3514192771683 25.1965826008775 1.18008935489459 0.238896102792764 0.729704606064571 1 0.105895 0.135929 0.115624 0.142099 GeneID:79784,Genbank:XM_011527320.2,HGNC:HGNC:23212,MIM:608568 myosin heavy chain 14 GO:0000146,GO:0001725,GO:0003009,GO:0005516,GO:0005524,GO:0005829,GO:0005903,GO:0007519,GO:0007605,GO:0008360,GO:0016020,GO:0016460,GO:0016887,GO:0019228,GO:0030048,GO:0030424,GO:0030426,GO:0030898,GO:0031032,GO:0042641,GO:0043209,GO:0051015,GO:0070062,GO:0070584,GO:0071625,GO:0097513 microfilament motor activity|stress fiber|skeletal muscle contraction|calmodulin binding|ATP binding|cytosol|brush border|skeletal muscle tissue development|sensory perception of sound|regulation of cell shape|membrane|myosin II complex|ATPase activity|neuronal action potential|actin filament-based movement|axon|growth cone|actin-dependent ATPase activity|actomyosin structure organization|actomyosin|myelin sheath|actin filament binding|extracellular exosome|mitochondrion morphogenesis|vocalization behavior|myosin II filament hsa04530,hsa04810,hsa05132 Tight junction|Regulation of actin cytoskeleton|Salmonella infection MYH15 16.6385286238318 16.3066264335398 16.9704308141238 1.04070764626205 0.0575648462311429 0.996449738878275 1 0.0478513 0.0621547 0.0876418 0.0271297 GeneID:22989,Genbank:NM_014981.1,HGNC:HGNC:31073,MIM:609929 myosin heavy chain 15 GO:0002074,GO:0003774,GO:0005516,GO:0005524,GO:0030016,GO:0032982,GO:0051015 extraocular skeletal muscle development|motor activity|calmodulin binding|ATP binding|myofibril|myosin filament|actin filament binding hsa04530 Tight junction MYH2 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.00825083 GeneID:4620,Genbank:NM_017534.5,HGNC:HGNC:7572,MIM:160740 myosin heavy chain 2 GO:0000146,GO:0005516,GO:0005524,GO:0005829,GO:0005859,GO:0006936,GO:0014704,GO:0030016,GO:0030017,GO:0030049,GO:0031672,GO:0032982,GO:0038096,GO:0043234,GO:0051015 microfilament motor activity|calmodulin binding|ATP binding|cytosol|muscle myosin complex|muscle contraction|intercalated disc|myofibril|sarcomere|muscle filament sliding|A band|myosin filament|Fc-gamma receptor signaling pathway involved in phagocytosis|protein complex|actin filament binding hsa04530 Tight junction MYH3 7.78892691282351 7.34126237425249 8.23659145139452 1.12195846320412 0.166019265930053 0.914342890726881 1 0.0390059 0.0179114 0.0277063 0.0386365 GeneID:4621,Genbank:NM_002470.3,HGNC:HGNC:7573,MIM:160720 myosin heavy chain 3 GO:0000146,GO:0003009,GO:0005516,GO:0005524,GO:0005829,GO:0005859,GO:0007517,GO:0017018,GO:0030017,GO:0030048,GO:0030049,GO:0030326,GO:0032982,GO:0042623,GO:0045214,GO:0046034,GO:0051015,GO:0060325,GO:0070062 microfilament motor activity|skeletal muscle contraction|calmodulin binding|ATP binding|cytosol|muscle myosin complex|muscle organ development|myosin phosphatase activity|sarcomere|actin filament-based movement|muscle filament sliding|embryonic limb morphogenesis|myosin filament|ATPase activity, coupled|sarcomere organization|ATP metabolic process|actin filament binding|face morphogenesis|extracellular exosome hsa04530 Tight junction MYH7B 2.51402180070554 3.57457863775636 1.45346496365472 0.40661155088394 -1.29827689552794 0.586956146241499 1 0 0.00958908 0.00510036 0.00473757 GeneID:57644,Genbank:NM_020884.4,HGNC:HGNC:15906,MIM:609928 myosin heavy chain 7B GO:0003774,GO:0005524,GO:0016020,GO:0032982,GO:0051015,GO:0097512 motor activity|ATP binding|membrane|myosin filament|actin filament binding|cardiac myofibril hsa04530 Tight junction MYH8 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00466224 0 GeneID:4626,Genbank:NM_002472.2,HGNC:HGNC:7578,MIM:160741 myosin heavy chain 8 GO:0000146,GO:0003009,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0005859,GO:0006936,GO:0008307,GO:0016887,GO:0017018,GO:0030017,GO:0030049,GO:0032027,GO:0032982,GO:0046034,GO:0051015 microfilament motor activity|skeletal muscle contraction|calmodulin binding|ATP binding|cytoplasm|cytosol|muscle myosin complex|muscle contraction|structural constituent of muscle|ATPase activity|myosin phosphatase activity|sarcomere|muscle filament sliding|myosin light chain binding|myosin filament|ATP metabolic process|actin filament binding hsa04530 Tight junction MYH9 29087.3286256691 29688.5760564313 28486.0811949069 0.959496378026391 -0.0596507344419299 0.625351735304028 1 113.039 118.702 116.584 109.579 GeneID:4627,Genbank:NM_002473.5,HGNC:HGNC:7579,MIM:160775 myosin heavy chain 9 hsa04530,hsa04810,hsa05132 Tight junction|Regulation of actin cytoskeleton|Salmonella infection MYL10 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:93408,Genbank:NM_138403.4,HGNC:HGNC:29825,MIM:617177 myosin light chain 10 GO:0005509,GO:0005739,GO:0005829,GO:0006936 calcium ion binding|mitochondrion|cytosol|muscle contraction hsa04510,hsa04670,hsa04810 Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton MYL12A 7252.37687100551 7922.48007208687 6582.27366992415 0.830834992329657 -0.267366115347379 0.0423622090539099 0.766965383496396 162.917 160.518 126.141 141.247 GeneID:10627,Genbank:NM_001303048.1,HGNC:HGNC:16701 myosin light chain 12A GO:0005509,GO:0005829,GO:0006936,GO:0016459,GO:0048013,GO:0070062,GO:0070527 calcium ion binding|cytosol|muscle contraction|myosin complex|ephrin receptor signaling pathway|extracellular exosome|platelet aggregation hsa04510,hsa04530,hsa04611,hsa04670,hsa04810 Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton MYL12B 9740.69894311967 10476.4148627097 9004.98302352963 0.859548150921593 -0.218349634765148 0.0953148373593177 1 255.329 244.22 217.373 224.114 GeneID:103910,Genbank:NM_033546.3,HGNC:HGNC:29827,MIM:609211 myosin light chain 12B GO:0001725,GO:0005509,GO:0005903,GO:0008360,GO:0016460,GO:0030018,GO:0032036,GO:0045177,GO:0099738 stress fiber|calcium ion binding|brush border|regulation of cell shape|myosin II complex|Z disc|myosin heavy chain binding|apical part of cell|cell cortex region hsa04510,hsa04530,hsa04611,hsa04670,hsa04810 Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton MYL2 15.8784300450248 15.2784573549402 16.4784027351094 1.07853838593078 0.109077523931351 0.937783260580071 1 0.368616 0.387167 0.597345 0.509847 GeneID:4633,Genbank:NM_000432.3,HGNC:HGNC:7583,MIM:160781 myosin light chain 2 GO:0002026,GO:0003785,GO:0005509,GO:0005829,GO:0005856,GO:0006942,GO:0007507,GO:0008307,GO:0009791,GO:0016459,GO:0030016,GO:0030017,GO:0030049,GO:0030308,GO:0031672,GO:0032036,GO:0042694,GO:0048747,GO:0055003,GO:0055010,GO:0060047,GO:0060048,GO:0097512,GO:0098735 regulation of the force of heart contraction|actin monomer binding|calcium ion binding|cytosol|cytoskeleton|regulation of striated muscle contraction|heart development|structural constituent of muscle|post-embryonic development|myosin complex|myofibril|sarcomere|muscle filament sliding|negative regulation of cell growth|A band|myosin heavy chain binding|muscle cell fate specification|muscle fiber development|cardiac myofibril assembly|ventricular cardiac muscle tissue morphogenesis|heart contraction|cardiac muscle contraction|cardiac myofibril|positive regulation of the force of heart contraction hsa04260,hsa04261,hsa04371,hsa04510,hsa04530,hsa04670,hsa04810,hsa05410,hsa05414 Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Focal adhesion|Tight junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) MYL4 1.70274215842529 0.980142803914724 2.42534151293585 2.47447770187054 1.30712404178231 0.761551091123478 1 0 0 0.128501 0 GeneID:4635,Genbank:XM_017024683.1,HGNC:HGNC:7585,MIM:160770 myosin light chain 4 GO:0002026,GO:0003785,GO:0005509,GO:0005829,GO:0016459,GO:0030049,GO:0031672,GO:0032038,GO:0032781,GO:0051015,GO:0060048 regulation of the force of heart contraction|actin monomer binding|calcium ion binding|cytosol|myosin complex|muscle filament sliding|A band|myosin II heavy chain binding|positive regulation of ATPase activity|actin filament binding|cardiac muscle contraction hsa04260,hsa04261,hsa04371 Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway MYL5 325.444676884066 336.913082513004 313.976271255127 0.931920686822865 -0.101720918544691 0.760271526738369 1 1.21856 1.11104 1.11146 1.02255 GeneID:4636,Genbank:XM_006713886.2,HGNC:HGNC:7586,MIM:160782 myosin light chain 5 GO:0005509,GO:0005829,GO:0005859,GO:0006936,GO:0006937,GO:0008307 calcium ion binding|cytosol|muscle myosin complex|muscle contraction|regulation of muscle contraction|structural constituent of muscle hsa04510,hsa04670,hsa04810 Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton MYL6 28617.9203928744 27542.4746907846 29693.3660949641 1.07809361461986 0.108482457760097 0.460236473856645 1 1032.86 1128.09 1151.07 1215.91 GeneID:4637,Genbank:NM_021019.4,HGNC:HGNC:7587,MIM:609931 myosin light chain 6 GO:0000146,GO:0005509,GO:0005903,GO:0006936,GO:0008307,GO:0016461,GO:0030049,GO:0030898,GO:0031012 microfilament motor activity|calcium ion binding|brush border|muscle contraction|structural constituent of muscle|unconventional myosin complex|muscle filament sliding|actin-dependent ATPase activity|extracellular matrix hsa04270,hsa04530,hsa04921 Vascular smooth muscle contraction|Tight junction|Oxytocin signaling pathway MYL6B 1502.4763599683 1486.72573000257 1518.22698993403 1.02118834650921 0.0302489793546341 0.870590663816572 1 46.2787 50.5592 48.3063 53.5599 GeneID:140465,Genbank:NM_001199629.1,HGNC:HGNC:29823,MIM:609930 myosin light chain 6B GO:0003774,GO:0005509,GO:0005829,GO:0005859,GO:0006936,GO:0007519,GO:0008307,GO:0016459,GO:0016461,GO:0030049,GO:0070062 motor activity|calcium ion binding|cytosol|muscle myosin complex|muscle contraction|skeletal muscle tissue development|structural constituent of muscle|myosin complex|unconventional myosin complex|muscle filament sliding|extracellular exosome hsa04270,hsa04530,hsa04921 Vascular smooth muscle contraction|Tight junction|Oxytocin signaling pathway MYLIP 246.588403981157 266.353626287107 226.823181675208 0.851586610015635 -0.231774829239841 0.278601814181249 1 3.82934 3.78307 3.61208 2.94301 GeneID:29116,Genbank:XM_017010789.1,HGNC:HGNC:21155,MIM:610082 myosin regulatory light chain interacting protein GO:0000209,GO:0004842,GO:0005622,GO:0005829,GO:0005886,GO:0006928,GO:0007399,GO:0008092,GO:0010989,GO:0016567,GO:0031648,GO:0032802,GO:0032803,GO:0042632,GO:0042787,GO:0045732,GO:0046872,GO:0061630 protein polyubiquitination|ubiquitin-protein transferase activity|intracellular|cytosol|plasma membrane|movement of cell or subcellular component|nervous system development|cytoskeletal protein binding|negative regulation of low-density lipoprotein particle clearance|protein ubiquitination|protein destabilization|low-density lipoprotein particle receptor catabolic process|regulation of low-density lipoprotein particle receptor catabolic process|cholesterol homeostasis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of protein catabolic process|metal ion binding|ubiquitin protein ligase activity hsa04979 Cholesterol metabolism MYLK 2727.53448197048 3002.80263284363 2452.26633109732 0.816659178420609 -0.292193980030023 0.0342712003970798 0.729903651010146 10.0947 9.39722 8.42783 7.66842 GeneID:4638,Genbank:NM_001321309.1,HGNC:HGNC:7590,MIM:600922 myosin light chain kinase GO:0003779,GO:0004687,GO:0005516,GO:0005524,GO:0005737,GO:0005856,GO:0030027,GO:0032154,GO:0046872 actin binding|myosin light chain kinase activity|calmodulin binding|ATP binding|cytoplasm|cytoskeleton|lamellipodium|cleavage furrow|metal ion binding hsa04020,hsa04022,hsa04270,hsa04371,hsa04510,hsa04611,hsa04810,hsa04921,hsa04971 Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Gastric acid secretion MYLK2 20.6114438789301 22.3217534259751 18.9011343318851 0.846758494782515 -0.239977539806096 0.75416154044598 1 0.296378 0.181783 0.190998 0.190003 GeneID:85366,Genbank:NM_033118.3,HGNC:HGNC:16243,MIM:606566 myosin light chain kinase 2 GO:0004683,GO:0004687,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0006941,GO:0007274,GO:0010628,GO:0014816,GO:0018105,GO:0018107,GO:0030017,GO:0032971,GO:0035556,GO:0035914,GO:0046777,GO:0055008,GO:0060048 calmodulin-dependent protein kinase activity|myosin light chain kinase activity|calmodulin binding|ATP binding|nucleus|cytoplasm|striated muscle contraction|neuromuscular synaptic transmission|positive regulation of gene expression|skeletal muscle satellite cell differentiation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sarcomere|regulation of muscle filament sliding|intracellular signal transduction|skeletal muscle cell differentiation|protein autophosphorylation|cardiac muscle tissue morphogenesis|cardiac muscle contraction hsa04020,hsa04022,hsa04270,hsa04371,hsa04510,hsa04611,hsa04810,hsa04921,hsa04971 Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Gastric acid secretion MYLK3 5.42812975751866 4.55472144167109 6.30153807336622 1.38351777470155 0.46834117904657 0.789118353395141 1 0.015706 0.0193524 0.0398064 0.0185609 GeneID:91807,Genbank:NM_001308301.1,HGNC:HGNC:29826,MIM:612147 myosin light chain kinase 3 GO:0002528,GO:0004683,GO:0004687,GO:0005524,GO:0005622,GO:0005737,GO:0005829,GO:0006468,GO:0015629,GO:0018105,GO:0018107,GO:0035556,GO:0045214,GO:0048769,GO:0055003,GO:0060298,GO:0071347 regulation of vascular permeability involved in acute inflammatory response|calmodulin-dependent protein kinase activity|myosin light chain kinase activity|ATP binding|intracellular|cytoplasm|cytosol|protein phosphorylation|actin cytoskeleton|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|intracellular signal transduction|sarcomere organization|sarcomerogenesis|cardiac myofibril assembly|positive regulation of sarcomere organization|cellular response to interleukin-1 hsa04020,hsa04022,hsa04270,hsa04371,hsa04510,hsa04611,hsa04810,hsa04921,hsa04971 Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Gastric acid secretion MYLK4 87.0344061355895 96.5518408389988 77.5169714321803 0.802853376575602 -0.316791559451104 0.499769064200632 1 0.169891 0.213952 0.135916 0.223939 GeneID:340156,Genbank:NM_001347872.1,HGNC:HGNC:27972 myosin light chain kinase family member 4 GO:0004687,GO:0005524,GO:0005622,GO:0018105,GO:0018107,GO:0035556,GO:0070062 myosin light chain kinase activity|ATP binding|intracellular|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|intracellular signal transduction|extracellular exosome hsa04020,hsa04022,hsa04270,hsa04371,hsa04510,hsa04611,hsa04810,hsa04921,hsa04971 Calcium signaling pathway|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Gastric acid secretion MYLPF 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0 0 0 0.0391412 GeneID:29895,Genbank:NM_001324459.1,HGNC:HGNC:29824,MIM:617378 myosin light chain, phosphorylatable, fast skeletal muscle GO:0005509,GO:0005765,GO:0005829,GO:0005859,GO:0006936,GO:0006955,GO:0007519,GO:0008307 calcium ion binding|lysosomal membrane|cytosol|muscle myosin complex|muscle contraction|immune response|skeletal muscle tissue development|structural constituent of muscle hsa04510,hsa04670,hsa04810 Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton MYNN 371.746417262966 394.53857718927 348.954257336661 0.884461691484376 -0.177128437785527 0.348714342132546 1 2.31086 2.47547 2.35895 1.92455 GeneID:55892,Genbank:XM_017006865.2,HGNC:HGNC:14955,MIM:606042 myoneurin GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0008270,GO:1990830 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|zinc ion binding|cellular response to leukemia inhibitory factor MYO10 1441.697977975 1271.89317650247 1611.50277944752 1.26701110535 0.341429169753512 0.0178228169218444 0.546850871863472 3.06162 2.83545 4.20565 3.43478 GeneID:4651,Genbank:NM_012334.2,HGNC:HGNC:7593,MIM:601481 myosin X GO:0001726,GO:0003774,GO:0005516,GO:0005524,GO:0005547,GO:0005730,GO:0005829,GO:0005886,GO:0005938,GO:0008360,GO:0016459,GO:0022409,GO:0030027,GO:0030507,GO:0030705,GO:0030898,GO:0031527,GO:0032433,GO:0038096,GO:0043005,GO:0043025,GO:0051015,GO:0051489,GO:0060002 ruffle|motor activity|calmodulin binding|ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleolus|cytosol|plasma membrane|cell cortex|regulation of cell shape|myosin complex|positive regulation of cell-cell adhesion|lamellipodium|spectrin binding|cytoskeleton-dependent intracellular transport|actin-dependent ATPase activity|filopodium membrane|filopodium tip|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron projection|neuronal cell body|actin filament binding|regulation of filopodium assembly|plus-end directed microfilament motor activity hsa04666 Fc gamma R-mediated phagocytosis MYO15B 11.8435707537968 13.5102768458505 10.1768646617432 0.753268402850597 -0.40876408063287 0.676800797938197 1 0.0531364 0.0209734 0.0300446 0.0211143 GeneID:80022,Genbank:XM_017025141.1,HGNC:HGNC:14083 myosin XVB GO:0003774,GO:0005524,GO:0005737,GO:0016459 motor activity|ATP binding|cytoplasm|myosin complex MYO16 2.97214043023844 3.03648096111406 2.90779989936283 0.957621647097693 -0.062472330025007 1 1 0 0.00499188 0.00514456 0.00958895 GeneID:23026,Genbank:XM_011521062.1,HGNC:HGNC:29822,MIM:615479 myosin XVI GO:0003774,GO:0005524,GO:0005654,GO:0005737,GO:0005886,GO:0008285,GO:0016459,GO:0021549,GO:0048471,GO:0051015,GO:2000134 motor activity|ATP binding|nucleoplasm|cytoplasm|plasma membrane|negative regulation of cell proliferation|myosin complex|cerebellum development|perinuclear region of cytoplasm|actin filament binding|negative regulation of G1/S transition of mitotic cell cycle MYO18A 3740.63604797181 2971.04912927005 4510.22296667358 1.51805734958738 0.602226294312299 9.37742719755596e-06 0.00434998937369677 14.0147 14.6673 23.6359 20.2067 GeneID:399687,Genbank:NM_203318.1,HGNC:HGNC:31104,MIM:610067 myosin XVIIIA GO:0000139,GO:0003677,GO:0003723,GO:0005524,GO:0005793,GO:0005802,GO:0006259,GO:0007030,GO:0009986,GO:0016020,GO:0016459,GO:0016477,GO:0031032,GO:0042641,GO:0043030,GO:0043066,GO:0043531,GO:0048194,GO:0050714,GO:0051015,GO:0090161,GO:0090164,GO:1903028 Golgi membrane|DNA binding|RNA binding|ATP binding|endoplasmic reticulum-Golgi intermediate compartment|trans-Golgi network|DNA metabolic process|Golgi organization|cell surface|membrane|myosin complex|cell migration|actomyosin structure organization|actomyosin|regulation of macrophage activation|negative regulation of apoptotic process|ADP binding|Golgi vesicle budding|positive regulation of protein secretion|actin filament binding|Golgi ribbon formation|asymmetric Golgi ribbon formation|positive regulation of opsonization MYO18B 2.24247141269929 2.54640955915669 1.93853326624189 0.76128101988585 -0.393498985236256 0.964560642378451 1 0.00422955 0.00581844 0.0039966 0.00372539 GeneID:84700,Genbank:XM_011530466.2,HGNC:HGNC:18150,MIM:607295 myosin XVIIIB GO:0003774,GO:0003779,GO:0005524,GO:0005634,GO:0016461,GO:0030017 motor activity|actin binding|ATP binding|nucleus|unconventional myosin complex|sarcomere MYO19 3582.166909522 3440.9399814986 3723.39383754541 1.08208624898008 0.113815495483352 0.403787400738723 1 19.5521 19.5953 22.2053 21.0942 GeneID:80179,Genbank:XM_011525290.3,HGNC:HGNC:26234,MIM:617379 myosin XIX GO:0003779,GO:0005524,GO:0005739,GO:0005741,GO:0005829,GO:0016459,GO:0016887,GO:0032027,GO:0032465,GO:0034642,GO:0060002,GO:0090140 actin binding|ATP binding|mitochondrion|mitochondrial outer membrane|cytosol|myosin complex|ATPase activity|myosin light chain binding|regulation of cytokinesis|mitochondrion migration along actin filament|plus-end directed microfilament motor activity|regulation of mitochondrial fission MYO1A 1.02566752891457 1.56626675524197 0.48506830258717 0.309697119576692 -1.69107012999473 0.789536483244536 1 0.0204978 0 0.00970568 0 GeneID:4640,Genbank:NM_001256041.1,HGNC:HGNC:7595,MIM:601478 myosin IA GO:0003774,GO:0005516,GO:0005524,GO:0005737,GO:0005902,GO:0005903,GO:0007605,GO:0009925,GO:0016323,GO:0016324,GO:0016328,GO:0016459,GO:0030033,GO:0030864,GO:0031941,GO:0044853,GO:0051015,GO:0051648 motor activity|calmodulin binding|ATP binding|cytoplasm|microvillus|brush border|sensory perception of sound|basal plasma membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|myosin complex|microvillus assembly|cortical actin cytoskeleton|filamentous actin|plasma membrane raft|actin filament binding|vesicle localization MYO1B 935.755451898359 1012.67889883577 858.832004960947 0.848079293395276 -0.237728935240294 0.13073188701129 1 5.86224 5.39953 5.46365 4.35053 GeneID:4430,Genbank:NM_001130158.2,HGNC:HGNC:7596,MIM:606537 myosin IB GO:0000146,GO:0005516,GO:0005524,GO:0005546,GO:0005547,GO:0005737,GO:0005769,GO:0005884,GO:0005886,GO:0005903,GO:0006892,GO:0007015,GO:0010008,GO:0016459,GO:0030048,GO:0030175,GO:0030898,GO:0045177,GO:0045296,GO:0048471,GO:0051015,GO:0051017,GO:0070062,GO:0071944 microfilament motor activity|calmodulin binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|early endosome|actin filament|plasma membrane|brush border|post-Golgi vesicle-mediated transport|actin filament organization|endosome membrane|myosin complex|actin filament-based movement|filopodium|actin-dependent ATPase activity|apical part of cell|cadherin binding|perinuclear region of cytoplasm|actin filament binding|actin filament bundle assembly|extracellular exosome|cell periphery MYO1C 11138.3016885091 10445.9279869399 11830.6753900784 1.13256336869925 0.179591773583218 0.174755263196624 1 63.245 65.7432 75.4049 72.99 GeneID:4641,Genbank:NM_001080779.1,HGNC:HGNC:7597,MIM:606538 myosin IC GO:0000146,GO:0005102,GO:0005516,GO:0005524,GO:0005643,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005902,GO:0005903,GO:0006605,GO:0006612,GO:0008022,GO:0009925,GO:0016020,GO:0016328,GO:0016461,GO:0016604,GO:0017160,GO:0030050,GO:0030335,GO:0030659,GO:0030838,GO:0030898,GO:0031941,GO:0032587,GO:0038089,GO:0038096,GO:0045121,GO:0045335,GO:0045815,GO:0051015,GO:0051028,GO:0060171,GO:0070062,GO:0071346,GO:0090314,GO:1900078,GO:1900748,GO:2000810 microfilament motor activity|receptor binding|calmodulin binding|ATP binding|nuclear pore|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|microvillus|brush border|protein targeting|protein targeting to membrane|protein C-terminus binding|basal plasma membrane|membrane|lateral plasma membrane|unconventional myosin complex|nuclear body|Ral GTPase binding|vesicle transport along actin filament|positive regulation of cell migration|cytoplasmic vesicle membrane|positive regulation of actin filament polymerization|actin-dependent ATPase activity|filamentous actin|ruffle membrane|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|membrane raft|phagocytic vesicle|positive regulation of gene expression, epigenetic|actin filament binding|mRNA transport|stereocilium membrane|extracellular exosome|cellular response to interferon-gamma|positive regulation of protein targeting to membrane|positive regulation of cellular response to insulin stimulus|positive regulation of vascular endothelial growth factor signaling pathway|regulation of bicellular tight junction assembly MYO1D 197.055578055412 208.506600546777 185.604555564047 0.890161534825885 -0.16786093370053 0.49408997119344 1 0.924837 0.780317 0.741154 0.798576 GeneID:4642,Genbank:NM_015194.2,HGNC:HGNC:7598,MIM:606539 myosin ID GO:0000146,GO:0005516,GO:0005524,GO:0005768,GO:0005790,GO:0005829,GO:0005903,GO:0010923,GO:0016323,GO:0016459,GO:0019904,GO:0030424,GO:0030673,GO:0030898,GO:0030900,GO:0031410,GO:0043005,GO:0043025,GO:0043209,GO:0044853,GO:0048306,GO:0051015,GO:0051641,GO:0061502,GO:0070062,GO:0097440 microfilament motor activity|calmodulin binding|ATP binding|endosome|smooth endoplasmic reticulum|cytosol|brush border|negative regulation of phosphatase activity|basolateral plasma membrane|myosin complex|protein domain specific binding|axon|axolemma|actin-dependent ATPase activity|forebrain development|cytoplasmic vesicle|neuron projection|neuronal cell body|myelin sheath|plasma membrane raft|calcium-dependent protein binding|actin filament binding|cellular localization|early endosome to recycling endosome transport|extracellular exosome|apical dendrite MYO1E 2920.46422787195 2953.00069729018 2887.92775845372 0.977963791577776 -0.0321470434912459 0.811715713141783 1 15.3879 15.3622 15.8099 14.8098 GeneID:4643,Genbank:NM_004998.3,HGNC:HGNC:7599,MIM:601479 myosin IE GO:0000146,GO:0001570,GO:0001701,GO:0003094,GO:0003774,GO:0005516,GO:0005524,GO:0005737,GO:0005856,GO:0005903,GO:0005911,GO:0005912,GO:0006807,GO:0006897,GO:0015629,GO:0016459,GO:0030048,GO:0030136,GO:0032836,GO:0035091,GO:0035166,GO:0042623,GO:0048008,GO:0051015,GO:0070062,GO:0072015 microfilament motor activity|vasculogenesis|in utero embryonic development|glomerular filtration|motor activity|calmodulin binding|ATP binding|cytoplasm|cytoskeleton|brush border|cell-cell junction|adherens junction|nitrogen compound metabolic process|endocytosis|actin cytoskeleton|myosin complex|actin filament-based movement|clathrin-coated vesicle|glomerular basement membrane development|phosphatidylinositol binding|post-embryonic hemopoiesis|ATPase activity, coupled|platelet-derived growth factor receptor signaling pathway|actin filament binding|extracellular exosome|glomerular visceral epithelial cell development MYO1F 12.9530109313912 12.338028943196 13.5679929195864 1.0996888548449 0.137095386413358 0.910451206936933 1 0.109498 0.0955903 0.0931235 0.110537 GeneID:4542,Genbank:NM_001348355.1,HGNC:HGNC:7600,MIM:601480 myosin IF GO:0003774,GO:0003779,GO:0005516,GO:0005524,GO:0016461 motor activity|actin binding|calmodulin binding|ATP binding|unconventional myosin complex MYO1G 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0 0 0 GeneID:64005,Genbank:NM_033054.2,HGNC:HGNC:13880,MIM:600642 myosin IG GO:0001891,GO:0002456,GO:0003774,GO:0003779,GO:0005516,GO:0005524,GO:0005546,GO:0005547,GO:0005886,GO:0005902,GO:0006887,GO:0016020,GO:0016459,GO:0030027,GO:0030175,GO:0031256,GO:0031589,GO:0038096,GO:0043325,GO:0070062,GO:0071976,GO:0072678 phagocytic cup|T cell mediated immunity|motor activity|actin binding|calmodulin binding|ATP binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|plasma membrane|microvillus|exocytosis|membrane|myosin complex|lamellipodium|filopodium|leading edge membrane|cell-substrate adhesion|Fc-gamma receptor signaling pathway involved in phagocytosis|phosphatidylinositol-3,4-bisphosphate binding|extracellular exosome|cell gliding|T cell migration MYO1H 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.00569981 0 0.00540033 GeneID:283446,Genbank:XM_011538223.2,HGNC:HGNC:13879,MIM:614636 myosin IH GO:0003774,GO:0003779,GO:0005524,GO:0016459 motor activity|actin binding|ATP binding|myosin complex MYO3A 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.00692746 GeneID:53904,Genbank:NM_017433.4,HGNC:HGNC:7601,MIM:606808 myosin IIIA GO:0000146,GO:0003779,GO:0004672,GO:0004674,GO:0005516,GO:0005524,GO:0005737,GO:0007601,GO:0007605,GO:0016459,GO:0030175,GO:0030898,GO:0031941,GO:0032426,GO:0032433,GO:0043531,GO:0046777,GO:0050896,GO:0060002,GO:0090103 microfilament motor activity|actin binding|protein kinase activity|protein serine/threonine kinase activity|calmodulin binding|ATP binding|cytoplasm|visual perception|sensory perception of sound|myosin complex|filopodium|actin-dependent ATPase activity|filamentous actin|stereocilium tip|filopodium tip|ADP binding|protein autophosphorylation|response to stimulus|plus-end directed microfilament motor activity|cochlea morphogenesis MYO3B 1.96548293929615 0.538097676642304 3.39286820195 6.30530171236063 2.65656540600347 0.35496025673407 1 0.0053954 0 0.0155158 0.00961782 GeneID:140469,Genbank:NM_138995.4,HGNC:HGNC:15576,MIM:610040 myosin IIIB GO:0003774,GO:0003779,GO:0004674,GO:0005524,GO:0005737,GO:0007601,GO:0007605,GO:0016459,GO:0032426,GO:0050896,GO:0090103 motor activity|actin binding|protein serine/threonine kinase activity|ATP binding|cytoplasm|visual perception|sensory perception of sound|myosin complex|stereocilium tip|response to stimulus|cochlea morphogenesis MYO5A 872.706573239927 854.023277117989 891.389869361865 1.04375359928125 0.0617811725866896 0.828287164341219 1 2.50584 2.10977 2.98115 1.85369 GeneID:4644,Genbank:NM_001142495.1,HGNC:HGNC:7602,MIM:160777 myosin VA MYO5B 253.834605675967 258.070438728516 249.598772623417 0.967173047223703 -0.0481540541656142 0.839788129980645 1 0.793647 0.765603 0.858225 0.712737 GeneID:4645,Genbank:NM_001080467.2,HGNC:HGNC:7603,MIM:606540 myosin VB GO:0000146,GO:0003091,GO:0003779,GO:0005516,GO:0005524,GO:0015031,GO:0016192,GO:0016459,GO:0017137,GO:0030659,GO:0032439,GO:0043234,GO:0045179,GO:0070062 microfilament motor activity|renal water homeostasis|actin binding|calmodulin binding|ATP binding|protein transport|vesicle-mediated transport|myosin complex|Rab GTPase binding|cytoplasmic vesicle membrane|endosome localization|protein complex|apical cortex|extracellular exosome MYO5C 136.984375786381 133.412040189424 140.556711383338 1.05355342129368 0.0752634690498305 0.769016007807278 1 0.606869 0.544315 0.651039 0.489031 GeneID:55930,Genbank:XM_017022408.2,HGNC:HGNC:7604,MIM:610022 myosin VC GO:0003774,GO:0003779,GO:0005516,GO:0005524,GO:0016459,GO:0070062 motor activity|actin binding|calmodulin binding|ATP binding|myosin complex|extracellular exosome MYO6 392.823984833971 417.263141122086 368.384828545856 0.882859740630845 -0.179743838858689 0.592590551521402 1 1.66108 1.41016 1.6887 1.0452 GeneID:4646,Genbank:NM_001300899.1,HGNC:HGNC:7605,MIM:600970 myosin VI GO:0001726,GO:0003774,GO:0003779,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005765,GO:0005794,GO:0005829,GO:0005886,GO:0005902,GO:0005905,GO:0005938,GO:0006886,GO:0006897,GO:0007605,GO:0016020,GO:0016461,GO:0016591,GO:0030048,GO:0030139,GO:0030330,GO:0030665,GO:0031410,GO:0031941,GO:0031965,GO:0032587,GO:0042493,GO:0042802,GO:0043531,GO:0045177,GO:0045296,GO:0045944,GO:0048471,GO:0051015,GO:0051046,GO:0060001,GO:0070062 ruffle|motor activity|actin binding|calmodulin binding|ATP binding|nucleus|nucleoplasm|cytoplasm|lysosomal membrane|Golgi apparatus|cytosol|plasma membrane|microvillus|clathrin-coated pit|cell cortex|intracellular protein transport|endocytosis|sensory perception of sound|membrane|unconventional myosin complex|DNA-directed RNA polymerase II, holoenzyme|actin filament-based movement|endocytic vesicle|DNA damage response, signal transduction by p53 class mediator|clathrin-coated vesicle membrane|cytoplasmic vesicle|filamentous actin|nuclear membrane|ruffle membrane|response to drug|identical protein binding|ADP binding|apical part of cell|cadherin binding|positive regulation of transcription from RNA polymerase II promoter|perinuclear region of cytoplasm|actin filament binding|regulation of secretion|minus-end directed microfilament motor activity|extracellular exosome MYO7A 1.51573893087193 2.54640955915669 0.48506830258717 0.190491078248941 -2.39220466497676 0.502335003976947 1 0.0089963 0.00393475 0.00418274 0 GeneID:4647,Genbank:XM_011545044.2,HGNC:HGNC:7606,MIM:276903 myosin VIIA MYO7B 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0 0 0 0 GeneID:4648,Genbank:XM_011511218.2,HGNC:HGNC:7607,MIM:606541 myosin VIIB GO:0003774,GO:0003779,GO:0005524,GO:0005902,GO:0005903,GO:0016459,GO:0030154,GO:0070062,GO:0090651,GO:1904970 motor activity|actin binding|ATP binding|microvillus|brush border|myosin complex|cell differentiation|extracellular exosome|apical cytoplasm|brush border assembly MYO9A 279.470636040231 293.306536393907 265.634735686556 0.90565569711618 -0.142965409373926 0.7107936506132 1 0.761213 0.674472 0.876202 0.483403 GeneID:4649,Genbank:XM_011521615.3,HGNC:HGNC:7608,MIM:604875 myosin IXA GO:0003774,GO:0003779,GO:0005096,GO:0005524,GO:0005829,GO:0007601,GO:0016021,GO:0016461,GO:0034329,GO:0035556,GO:0045198,GO:0046872,GO:0051056 motor activity|actin binding|GTPase activator activity|ATP binding|cytosol|visual perception|integral component of membrane|unconventional myosin complex|cell junction assembly|intracellular signal transduction|establishment of epithelial cell apical/basal polarity|metal ion binding|regulation of small GTPase mediated signal transduction MYO9B 4888.47392268577 4377.64328072504 5399.30456464651 1.23338157506343 0.302619199812583 0.0241027387279824 0.621959897532696 18.4621 18.648 24.0326 22.3349 GeneID:4650,Genbank:NM_001130065.1,HGNC:HGNC:7609,MIM:602129 myosin IXB MYOC 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.0472617 0 0 GeneID:4653,Genbank:NM_000261.1,HGNC:HGNC:7610,MIM:601652 myocilin GO:0001649,GO:0001953,GO:0001968,GO:0005109,GO:0005578,GO:0005615,GO:0005741,GO:0005743,GO:0005758,GO:0005783,GO:0005791,GO:0005794,GO:0005929,GO:0014068,GO:0014734,GO:0022011,GO:0030335,GO:0030971,GO:0031012,GO:0031175,GO:0031410,GO:0032027,GO:0033268,GO:0035024,GO:0038031,GO:0038133,GO:0043408,GO:0045162,GO:0046872,GO:0051496,GO:0051497,GO:0051894,GO:0051897,GO:0051901,GO:0060348,GO:0070062,GO:1900026 osteoblast differentiation|negative regulation of cell-matrix adhesion|fibronectin binding|frizzled binding|proteinaceous extracellular matrix|extracellular space|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|endoplasmic reticulum|rough endoplasmic reticulum|Golgi apparatus|cilium|positive regulation of phosphatidylinositol 3-kinase signaling|skeletal muscle hypertrophy|myelination in peripheral nervous system|positive regulation of cell migration|receptor tyrosine kinase binding|extracellular matrix|neuron projection development|cytoplasmic vesicle|myosin light chain binding|node of Ranvier|negative regulation of Rho protein signal transduction|non-canonical Wnt signaling pathway via JNK cascade|ERBB2-ERBB3 signaling pathway|regulation of MAPK cascade|clustering of voltage-gated sodium channels|metal ion binding|positive regulation of stress fiber assembly|negative regulation of stress fiber assembly|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|positive regulation of mitochondrial depolarization|bone development|extracellular exosome|positive regulation of substrate adhesion-dependent cell spreading MYOD1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0331273 GeneID:4654,Genbank:NM_002478.4,HGNC:HGNC:7611,MIM:159970 myogenic differentiation 1 MYOF 14093.8363585009 14816.0753951046 13371.5973218972 0.902506025739807 -0.147991530448866 0.258439364195497 1 47.033 44.9099 47.7158 37.0218 GeneID:26509,Genbank:XM_005269694.5,HGNC:HGNC:3656,MIM:604603 myoferlin GO:0001778,GO:0005543,GO:0005635,GO:0005886,GO:0005901,GO:0006936,GO:0007520,GO:0008015,GO:0016021,GO:0030659,GO:0030947,GO:0031410,GO:0031965,GO:0034605,GO:0043231,GO:0070062 plasma membrane repair|phospholipid binding|nuclear envelope|plasma membrane|caveola|muscle contraction|myoblast fusion|blood circulation|integral component of membrane|cytoplasmic vesicle membrane|regulation of vascular endothelial growth factor receptor signaling pathway|cytoplasmic vesicle|nuclear membrane|cellular response to heat|intracellular membrane-bounded organelle|extracellular exosome MYOM1 5.478222595862 5.14084539299833 5.81559979872566 1.13125358849467 0.177922368633637 0.966682853841088 1 0.0246736 0.0286892 0.0176335 0.0328458 GeneID:8736,Genbank:NM_019856.1,HGNC:HGNC:7613,MIM:603508 myomesin 1 GO:0002074,GO:0005863,GO:0006941,GO:0007015,GO:0008307,GO:0010628,GO:0010737,GO:0019900,GO:0030018,GO:0031430,GO:0042802,GO:0042803,GO:0045214,GO:0050714,GO:0051015,GO:0051371,GO:0071688,GO:0097493 extraocular skeletal muscle development|striated muscle myosin thick filament|striated muscle contraction|actin filament organization|structural constituent of muscle|positive regulation of gene expression|protein kinase A signaling|kinase binding|Z disc|M band|identical protein binding|protein homodimerization activity|sarcomere organization|positive regulation of protein secretion|actin filament binding|muscle alpha-actinin binding|striated muscle myosin thick filament assembly|structural molecule activity conferring elasticity MYOM2 11.044024348169 8.03324753005756 14.0548011662804 1.74957899824352 0.807007807647837 0.389192707964864 1 0.0218637 0.0525651 0.0756022 0.0575595 GeneID:9172,Genbank:NM_003970.3,HGNC:HGNC:7614,MIM:603509 myomesin 2 GO:0002074,GO:0005739,GO:0005859,GO:0006936,GO:0006941,GO:0007015,GO:0008307,GO:0019900,GO:0030018,GO:0031430,GO:0032982,GO:0045214,GO:0051015,GO:0051371,GO:0071688,GO:0097493 extraocular skeletal muscle development|mitochondrion|muscle myosin complex|muscle contraction|striated muscle contraction|actin filament organization|structural constituent of muscle|kinase binding|Z disc|M band|myosin filament|sarcomere organization|actin filament binding|muscle alpha-actinin binding|striated muscle myosin thick filament assembly|structural molecule activity conferring elasticity MYOM3 2.78394061108009 4.11267631439867 1.45520490776151 0.353834047835657 -1.4988552162195 0.489876744281539 1 0.023605 0.0157979 0.011079 0 GeneID:127294,Genbank:NM_152372.3,HGNC:HGNC:26679,MIM:616832 myomesin 3 GO:0005859,GO:0006941,GO:0007015,GO:0008307,GO:0030018,GO:0031430,GO:0042803,GO:0045214,GO:0051015,GO:0051371,GO:0071688,GO:0097493 muscle myosin complex|striated muscle contraction|actin filament organization|structural constituent of muscle|Z disc|M band|protein homodimerization activity|sarcomere organization|actin filament binding|muscle alpha-actinin binding|striated muscle myosin thick filament assembly|structural molecule activity conferring elasticity MYORG 623.426266127484 499.047230319173 747.805301935795 1.49846598979725 0.583486339835696 0.00049117106157705 0.0614577790798283 2.59859 2.82139 4.43639 3.86373 GeneID:57462,Genbank:XM_011517966.3,HGNC:HGNC:19918 myogenesis regulating glycosidase (putative) GO:0004553,GO:0005789,GO:0005975,GO:0016021,GO:0031965,GO:0043568,GO:0048741,GO:0051897 hydrolase activity, hydrolyzing O-glycosyl compounds|endoplasmic reticulum membrane|carbohydrate metabolic process|integral component of membrane|nuclear membrane|positive regulation of insulin-like growth factor receptor signaling pathway|skeletal muscle fiber development|positive regulation of protein kinase B signaling MYOT 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0 0 0 0 GeneID:9499,Genbank:XM_017010060.1,HGNC:HGNC:12399,MIM:604103 myotilin GO:0003779,GO:0006936,GO:0008307,GO:0015629,GO:0030018,GO:0042383,GO:0051393 actin binding|muscle contraction|structural constituent of muscle|actin cytoskeleton|Z disc|sarcolemma|alpha-actinin binding MYOZ1 1.21723886981142 0.980142803914724 1.45433493570811 1.48379902387637 0.569295696478757 1 1 0 0.0242798 0.0502296 0.0234251 GeneID:58529,Genbank:NM_021245.3,HGNC:HGNC:13752,MIM:605603 myozenin 1 GO:0003779,GO:0005634,GO:0015629,GO:0030018,GO:0030239,GO:0031143,GO:0031433,GO:0051373 actin binding|nucleus|actin cytoskeleton|Z disc|myofibril assembly|pseudopodium|telethonin binding|FATZ binding MYOZ2 2.24160144064589 2.54640955915669 1.93679332213509 0.760597726775934 -0.394794467743717 0.964557065704219 1 0.0107802 0.021119 0 0.0290682 GeneID:51778,Genbank:NM_016599.4,HGNC:HGNC:1330,MIM:605602 myozenin 2 GO:0003779,GO:0015629,GO:0030017,GO:0030018,GO:0030239,GO:0030346,GO:0031433,GO:0051373 actin binding|actin cytoskeleton|sarcomere|Z disc|myofibril assembly|protein phosphatase 2B binding|telethonin binding|FATZ binding MYOZ3 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0207312 0.0107687 0 GeneID:91977,Genbank:NM_001122853.2,HGNC:HGNC:18565,MIM:610735 myozenin 3 GO:0003779,GO:0015629,GO:0030018,GO:0030239,GO:0031433,GO:0051373 actin binding|actin cytoskeleton|Z disc|myofibril assembly|telethonin binding|FATZ binding MYPN 1.75533654645372 2.05633815719933 1.45433493570811 0.707245027096551 -0.499717967356846 0.969172040919743 1 0.0104809 0.00971425 0.00994976 0 GeneID:84665,Genbank:XM_017016834.2,HGNC:HGNC:23246,MIM:608517 myopalladin GO:0005634,GO:0008092,GO:0017124,GO:0030018,GO:0030334,GO:0031674,GO:0045214,GO:0048739,GO:0051015,GO:0051371,GO:0051493 nucleus|cytoskeletal protein binding|SH3 domain binding|Z disc|regulation of cell migration|I band|sarcomere organization|cardiac muscle fiber development|actin filament binding|muscle alpha-actinin binding|regulation of cytoskeleton organization MYPOP 327.432785110153 273.47437459815 381.391195622157 1.39461401523482 0.479865885237397 0.014887519742977 0.508665088480495 3.40159 3.80072 5.04418 5.01985 GeneID:339344,Genbank:XM_017026743.2,HGNC:HGNC:20178,MIM:617861 Myb related transcription factor, partner of profilin GO:0000978,GO:0001078,GO:0005634,GO:0006351,GO:0042803 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|transcription, DNA-templated|protein homodimerization activity MYRF 234.110119563042 279.72963296401 188.490606162074 0.673831385559089 -0.569540467353899 0.0109250826623441 0.418603167272973 1.59212 1.61805 0.938636 1.24151 GeneID:745,Genbank:XM_011545234.2,HGNC:HGNC:1181,MIM:608329 myelin regulatory factor GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005789,GO:0005794,GO:0005829,GO:0006351,GO:0008233,GO:0014003,GO:0016021,GO:0022010,GO:0031643,GO:0032286,GO:0042802,GO:0045893,GO:0048709 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|transcription, DNA-templated|peptidase activity|oligodendrocyte development|integral component of membrane|central nervous system myelination|positive regulation of myelination|central nervous system myelin maintenance|identical protein binding|positive regulation of transcription, DNA-templated|oligodendrocyte differentiation MYRFL 0.968831647094244 0 1.93766329418849 Inf Inf 0.451925900856321 1 0 0 0.00592403 0.0110244 GeneID:196446,Genbank:XM_017018971.2,HGNC:HGNC:26316 myelin regulatory factor like GO:0003677,GO:0003700,GO:0016021 DNA binding|DNA binding transcription factor activity|integral component of membrane MYRIP 77.7277307412149 68.6952231674379 86.7602383149919 1.26297338176662 0.336824233426364 0.316390025779567 1 0.386424 0.424286 0.587624 0.430682 GeneID:25924,Genbank:NM_001284423.1,HGNC:HGNC:19156,MIM:611790 myosin VIIA and Rab interacting protein GO:0000145,GO:0001750,GO:0003779,GO:0006886,GO:0008270,GO:0017022,GO:0017137,GO:0030050,GO:0030133,GO:0030864,GO:0031045,GO:0032024,GO:0042470,GO:0045202,GO:0048471,GO:0051018 exocyst|photoreceptor outer segment|actin binding|intracellular protein transport|zinc ion binding|myosin binding|Rab GTPase binding|vesicle transport along actin filament|transport vesicle|cortical actin cytoskeleton|dense core granule|positive regulation of insulin secretion|melanosome|synapse|perinuclear region of cytoplasm|protein kinase A binding MYSM1 236.912829105808 254.226302752011 219.599355459605 0.86379478866833 -0.211239482191739 0.680653444577297 1 1.34356 1.02947 1.31563 0.673112 GeneID:114803,Genbank:XM_006710314.3,HGNC:HGNC:29401,MIM:612176 Myb like, SWIRM and MPN domains 1 GO:0003677,GO:0003713,GO:0004843,GO:0005634,GO:0005654,GO:0005886,GO:0006338,GO:0006351,GO:0008237,GO:0016579,GO:0030334,GO:0032403,GO:0035522,GO:0036459,GO:0042393,GO:0043473,GO:0045944,GO:0046872,GO:0051797 DNA binding|transcription coactivator activity|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|plasma membrane|chromatin remodeling|transcription, DNA-templated|metallopeptidase activity|protein deubiquitination|regulation of cell migration|protein complex binding|monoubiquitinated histone H2A deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|histone binding|pigmentation|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|regulation of hair follicle development MYT1 5.39824354875259 3.52655236307142 7.26993473443377 2.06148498192214 1.04368395111908 0.464898321363115 1 0.0129999 0.0233543 0.0426347 0.0285062 GeneID:4661,Genbank:NM_004535.2,HGNC:HGNC:7622,MIM:600379 myelin transcription factor 1 GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0007399,GO:0008270,GO:0030154 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|nervous system development|zinc ion binding|cell differentiation MYZAP 5.28958779067694 6.21704074628294 4.36213483507094 0.701641667328461 -0.511193669420601 0.763198023130999 1 0.16785 0.183789 0.120285 0.13665 GeneID:100820829,Genbank:NM_001018100.4,HGNC:HGNC:43444,MIM:614071 myocardial zonula adherens protein GO:0030018,GO:0030054,GO:0030864,GO:0031234,GO:0031674,GO:0035556 Z disc|cell junction|cortical actin cytoskeleton|extrinsic component of cytoplasmic side of plasma membrane|I band|intracellular signal transduction MZB1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:51237,Genbank:NM_016459.3,HGNC:HGNC:30125,MIM:609447 marginal zone B and B1 cell specific protein GO:0002642,GO:0005576,GO:0005737,GO:0005788,GO:0006915,GO:0008284,GO:0030888,GO:0033622,GO:0034663,GO:0042127,GO:2001274 positive regulation of immunoglobulin biosynthetic process|extracellular region|cytoplasm|endoplasmic reticulum lumen|apoptotic process|positive regulation of cell proliferation|regulation of B cell proliferation|integrin activation|endoplasmic reticulum chaperone complex|regulation of cell proliferation|negative regulation of glucose import in response to insulin stimulus MZF1 243.150883171591 241.581515851345 244.720250491837 1.01299244534265 0.0186234149017934 0.941154453667142 1 2.37179 2.21849 2.40369 2.72314 GeneID:7593,Genbank:NM_003422.2,HGNC:HGNC:13108,MIM:194550 myeloid zinc finger 1 GO:0000122,GO:0000978,GO:0001077,GO:0001078,GO:0003700,GO:0005634,GO:0006355,GO:0042803,GO:0044212,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|protein homodimerization activity|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding MZT1 684.07282782399 786.586545747467 581.559109900512 0.739345356267028 -0.435679674510371 0.0521147089058729 0.834967563885779 20.3085 17.3097 14.3396 13.3605 GeneID:440145,Genbank:NM_001071775.2,HGNC:HGNC:33830,MIM:613448 mitotic spindle organizing protein 1 GO:0000923,GO:0005813,GO:0005819,GO:0005829,GO:0008274,GO:0031021,GO:0033566,GO:0043015,GO:0051415,GO:0090307 equatorial microtubule organizing center|centrosome|spindle|cytosol|gamma-tubulin ring complex|interphase microtubule organizing center|gamma-tubulin complex localization|gamma-tubulin binding|interphase microtubule nucleation by interphase microtubule organizing center|mitotic spindle assembly MZT2A 926.6980976293 933.15712955315 920.239065705449 0.98615660381453 -0.0201113269794638 0.893923367092667 1 5.10353 5.73877 5.70049 5.76931 GeneID:653784,Genbank:XM_005263742.3,HGNC:HGNC:33187,MIM:613449 mitotic spindle organizing protein 2A GO:0005654,GO:0005813,GO:0005819,GO:0005829,GO:0008274 nucleoplasm|centrosome|spindle|cytosol|gamma-tubulin ring complex MZT2B 2991.26593529969 3096.38294665729 2886.14892394209 0.932103352092751 -0.101438164380208 0.641479218614757 1 118.633 134.962 114.308 132.172 GeneID:80097,Genbank:NM_001330282.1,HGNC:HGNC:25886,MIM:613450 mitotic spindle organizing protein 2B GO:0005654,GO:0005813,GO:0005819,GO:0005829,GO:0008274 nucleoplasm|centrosome|spindle|cytosol|gamma-tubulin ring complex N4BP1 1025.17999225183 1004.36730231271 1045.99268219095 1.04144437974274 0.0585857916473538 0.80992238560811 1 6.37138 5.62359 7.61313 5.15154 GeneID:9683,Genbank:XM_011523482.1,HGNC:HGNC:29850 NEDD4 binding protein 1 GO:0005730,GO:0016605,GO:0031397,GO:0032435,GO:0034644 nucleolus|PML body|negative regulation of protein ubiquitination|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to UV N4BP2 35.2117873176762 38.4264661056672 31.9971085296853 0.832684130820094 -0.264158765348555 0.735439961649678 1 0.155247 0.0880072 0.143931 0.0560394 GeneID:55728,Genbank:XM_017008397.1,HGNC:HGNC:29851 NEDD4 binding protein 2 GO:0004519,GO:0005524,GO:0005829,GO:0046404 endonuclease activity|ATP binding|cytosol|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity N4BP2L1 15.4380164953841 14.8844385023527 15.9915944884155 1.07438345664754 0.103508995436164 0.933387101786239 1 0.068314 0.0801662 0.0803405 0.11571 GeneID:90634,Genbank:NM_001353636.1,HGNC:HGNC:25037 NEDD4 binding protein 2 like 1 N4BP2L2 218.49710143605 228.089839314855 208.904363557245 0.915886319990228 -0.126759553076202 0.68217002556719 1 0.989587 0.848301 1.02881 0.677363 GeneID:10443,Genbank:NM_033111.4,HGNC:HGNC:26916,MIM:615788 NEDD4 binding protein 2 like 2 GO:0000122,GO:0001106,GO:0005634,GO:0017053,GO:0019899,GO:0070062,GO:1902035,GO:1902037 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription corepressor activity|nucleus|transcriptional repressor complex|enzyme binding|extracellular exosome|positive regulation of hematopoietic stem cell proliferation|negative regulation of hematopoietic stem cell differentiation N4BP3 1.75577153248042 2.05633815719933 1.45520490776151 0.707668095671314 -0.498855216219501 0.969173888295735 1 0.014442 0.0127286 0.0202134 0 GeneID:23138,Genbank:XM_011534473.1,HGNC:HGNC:29852 NEDD4 binding protein 3 GO:0007399,GO:0030424,GO:0030425,GO:0031410 nervous system development|axon|dendrite|cytoplasmic vesicle N6AMT1 104.842668206196 109.870012586109 99.8153238262824 0.908485595631048 -0.138464454700288 0.658652558546684 1 3.61993 3.58771 2.58105 3.88887 GeneID:29104,Genbank:NM_182749.4,HGNC:HGNC:16021,MIM:614553 N-6 adenine-specific DNA methyltransferase 1 GO:0003676,GO:0005737,GO:0005829,GO:0006415,GO:0008276,GO:0008757,GO:0030307,GO:0032259,GO:0043234 nucleic acid binding|cytoplasm|cytosol|translational termination|protein methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|positive regulation of cell growth|methylation|protein complex NAA10 2425.4252267168 2489.89440944987 2360.95604398372 0.948215327936482 -0.0767133804148951 0.595940909034265 1 76.9317 84.1368 74.6456 79.267 GeneID:8260,Genbank:NM_001256120.1,HGNC:HGNC:18704,MIM:300013 N(alpha)-acetyltransferase 10, NatA catalytic subunit GO:0004596,GO:0005622,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006323,GO:0006473,GO:0006474,GO:0006475,GO:0008080,GO:0016020,GO:0017198,GO:0018002,GO:0022626,GO:0031415,GO:1990189,GO:1990190,GO:2000719 peptide alpha-N-acetyltransferase activity|intracellular|nucleus|nucleolus|cytoplasm|cytosol|DNA packaging|protein acetylation|N-terminal protein amino acid acetylation|internal protein amino acid acetylation|N-acetyltransferase activity|membrane|N-terminal peptidyl-serine acetylation|N-terminal peptidyl-glutamic acid acetylation|cytosolic ribosome|NatA complex|peptide-serine-N-acetyltransferase activity|peptide-glutamate-N-acetyltransferase activity|negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric NAA15 435.691292584454 470.526019455421 400.856565713488 0.851932835037333 -0.231188399621837 0.473533180677397 1 3.29778 2.75007 3.14466 2.06248 GeneID:80155,Genbank:NM_057175.4,HGNC:HGNC:30782,MIM:608000 N(alpha)-acetyltransferase 15, NatA auxiliary subunit GO:0001525,GO:0003723,GO:0005634,GO:0005667,GO:0005737,GO:0005829,GO:0006351,GO:0006474,GO:0016020,GO:0017196,GO:0030154,GO:0031415,GO:0043022,GO:0043066,GO:0045893,GO:0050821 angiogenesis|RNA binding|nucleus|transcription factor complex|cytoplasm|cytosol|transcription, DNA-templated|N-terminal protein amino acid acetylation|membrane|N-terminal peptidyl-methionine acetylation|cell differentiation|NatA complex|ribosome binding|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|protein stabilization NAA16 115.861299979389 124.610372264407 107.112227694371 0.859577142319204 -0.218300975431555 0.441019306655266 1 0.508727 0.5428 0.554784 0.417363 GeneID:79612,Genbank:NM_024561.4,HGNC:HGNC:26164 N(alpha)-acetyltransferase 16, NatA auxiliary subunit GO:0005634,GO:0005667,GO:0005737,GO:0005829,GO:0006474,GO:0017196,GO:0031415,GO:0043022,GO:0043066,GO:0045893,GO:0050821,GO:0070062 nucleus|transcription factor complex|cytoplasm|cytosol|N-terminal protein amino acid acetylation|N-terminal peptidyl-methionine acetylation|NatA complex|ribosome binding|negative regulation of apoptotic process|positive regulation of transcription, DNA-templated|protein stabilization|extracellular exosome NAA20 866.96655045757 939.161430889623 794.771670025518 0.84625671783888 -0.240832713609632 0.121815448209863 1 26.8314 28.3321 24.0319 23.6976 GeneID:51126,Genbank:NM_016100.4,HGNC:HGNC:15908,MIM:610833 N(alpha)-acetyltransferase 20, NatB catalytic subunit GO:0004596,GO:0005622,GO:0005634,GO:0005737,GO:0005829,GO:0017196,GO:0031416 peptide alpha-N-acetyltransferase activity|intracellular|nucleus|cytoplasm|cytosol|N-terminal peptidyl-methionine acetylation|NatB complex NAA25 408.248923790835 447.627950733226 368.869896848443 0.824054655756471 -0.279188066976652 0.350409008322484 1 2.83595 2.42545 2.71755 1.64455 GeneID:80018,Genbank:NM_024953.3,HGNC:HGNC:25783,MIM:612755 N(alpha)-acetyltransferase 25, NatB auxiliary subunit GO:0005794,GO:0005829,GO:0017196,GO:0031416 Golgi apparatus|cytosol|N-terminal peptidyl-methionine acetylation|NatB complex NAA30 286.711213220796 282.602417790853 290.820008650739 1.02907827514047 0.0413527226226195 0.859317405211517 1 3.36179 3.23837 4.09084 2.83288 GeneID:122830,Genbank:NM_001011713.2,HGNC:HGNC:19844 N(alpha)-acetyltransferase 30, NatC catalytic subunit GO:0004596,GO:0005634,GO:0005737,GO:0005829,GO:0017196,GO:0031417 peptide alpha-N-acetyltransferase activity|nucleus|cytoplasm|cytosol|N-terminal peptidyl-methionine acetylation|NatC complex NAA35 402.777749877274 442.535131614913 363.020368139635 0.820319884694555 -0.285741494826971 0.143601898696896 1 1.85566 1.67071 1.75708 1.27744 GeneID:60560,Genbank:XM_011518903.3,HGNC:HGNC:24340 N(alpha)-acetyltransferase 35, NatC auxiliary subunit GO:0004596,GO:0005737,GO:0006474,GO:0031417,GO:0043066,GO:0048659 peptide alpha-N-acetyltransferase activity|cytoplasm|N-terminal protein amino acid acetylation|NatC complex|negative regulation of apoptotic process|smooth muscle cell proliferation NAA38 1571.74053461435 1492.01167122048 1651.46939800821 1.10687431597454 0.146491415421741 0.49710681553463 1 11.1448 12.3779 13.9459 15.7067 GeneID:84316,Genbank:NM_001330111.1,HGNC:HGNC:28212 N(alpha)-acetyltransferase 38, NatC auxiliary subunit GO:0005634,GO:0005737,GO:0031417,GO:0043066 nucleus|cytoplasm|NatC complex|negative regulation of apoptotic process NAA40 703.273186500695 690.220052354664 716.326320646726 1.03782310902588 0.053560565585426 0.768215789702974 1 6.56828 7.49184 8.03731 6.60888 GeneID:79829,Genbank:NM_024771.3,HGNC:HGNC:25845 N(alpha)-acetyltransferase 40, NatD catalytic subunit GO:0005634,GO:0005737,GO:0006474,GO:0006629,GO:0010485,GO:0043967,GO:0043968,GO:0043998,GO:1990189 nucleus|cytoplasm|N-terminal protein amino acid acetylation|lipid metabolic process|H4 histone acetyltransferase activity|histone H4 acetylation|histone H2A acetylation|H2A histone acetyltransferase activity|peptide-serine-N-acetyltransferase activity NAA50 1779.33980368984 1887.49689724492 1671.18271013476 0.88539626876955 -0.175604801233614 0.340245618937773 1 15.1636 14.3109 15.0961 11.1306 GeneID:80218,Genbank:NM_001308445.1,HGNC:HGNC:29533,MIM:610834 N(alpha)-acetyltransferase 50, NatE catalytic subunit GO:0004596,GO:0005634,GO:0005737,GO:0005829,GO:0006474,GO:0010485,GO:0034087,GO:0052858,GO:0070062,GO:0071962 peptide alpha-N-acetyltransferase activity|nucleus|cytoplasm|cytosol|N-terminal protein amino acid acetylation|H4 histone acetyltransferase activity|establishment of mitotic sister chromatid cohesion|peptidyl-lysine acetyltransferase activity|extracellular exosome|mitotic sister chromatid cohesion, centromeric NAA60 930.208806400539 947.877871921232 912.539740879846 0.962718687619788 -0.0548137996906399 0.701679494123044 1 9.98161 11.3208 10.21 10.3255 GeneID:79903,Genbank:NM_001083601.2,HGNC:HGNC:25875,MIM:614246 N(alpha)-acetyltransferase 60, NatF catalytic subunit GO:0000139,GO:0004596,GO:0006334,GO:0006474,GO:0007059,GO:0008283,GO:0010485,GO:0017196,GO:0042803,GO:0043967 Golgi membrane|peptide alpha-N-acetyltransferase activity|nucleosome assembly|N-terminal protein amino acid acetylation|chromosome segregation|cell proliferation|H4 histone acetyltransferase activity|N-terminal peptidyl-methionine acetylation|protein homodimerization activity|histone H4 acetylation NAAA 69.451261308635 72.509933178619 66.3925894386511 0.915634403842318 -0.127156423474524 0.74030537289719 1 0.714242 0.624333 0.570996 0.562604 GeneID:27163,Genbank:NM_001042402.1,HGNC:HGNC:736,MIM:607469 N-acylethanolamine acid amidase GO:0005737,GO:0006629,GO:0007269,GO:0008134,GO:0016810,GO:0043202,GO:0070062,GO:0098793 cytoplasm|lipid metabolic process|neurotransmitter secretion|transcription factor binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|lysosomal lumen|extracellular exosome|presynapse NAALAD2 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0.00821382 0.016074 0 0 GeneID:10003,Genbank:XM_017017044.2,HGNC:HGNC:14526,MIM:611636 N-acetylated alpha-linked acidic dipeptidase 2 GO:0004180,GO:0005886,GO:0006508,GO:0008236,GO:0008237,GO:0008239,GO:0008652,GO:0016021,GO:0016805,GO:0042135,GO:0046872,GO:0050129 carboxypeptidase activity|plasma membrane|proteolysis|serine-type peptidase activity|metallopeptidase activity|dipeptidyl-peptidase activity|cellular amino acid biosynthetic process|integral component of membrane|dipeptidase activity|neurotransmitter catabolic process|metal ion binding|N-formylglutamate deformylase activity NAALADL1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:10004,Genbank:XM_011544707.2,HGNC:HGNC:23536,MIM:602640 N-acetylated alpha-linked acidic dipeptidase like 1 GO:0004180,GO:0008233,GO:0008237,GO:0016021,GO:0016324,GO:0016805,GO:0046872 carboxypeptidase activity|peptidase activity|metallopeptidase activity|integral component of membrane|apical plasma membrane|dipeptidase activity|metal ion binding NAALADL2 11.9273434024766 10.771762187954 13.0829246169992 1.21455750588606 0.280430799148393 0.779311492083195 1 0.016882 0.00829392 0.0204911 0.0267204 GeneID:254827,Genbank:XM_017006077.2,HGNC:HGNC:23219,MIM:608806 N-acetylated alpha-linked acidic dipeptidase like 2 GO:0005654,GO:0016021 nucleoplasm|integral component of membrane NAB1 539.971425210501 550.684989966618 529.257860454384 0.961090042578549 -0.0572564943814371 0.777800569146317 1 4.61269 3.98055 4.73662 3.73619 GeneID:4664,Genbank:XM_017004170.1,HGNC:HGNC:7626,MIM:600800 NGFI-A binding protein 1 GO:0001958,GO:0005634,GO:0006351,GO:0006355,GO:0008134,GO:0014037,GO:0042552,GO:0045682,GO:0045892 endochondral ossification|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription factor binding|Schwann cell differentiation|myelination|regulation of epidermis development|negative regulation of transcription, DNA-templated NAB2 302.68973473107 303.96364572313 301.415823739011 0.991618004258183 -0.0121436290111428 0.956683385768907 1 4.55132 4.55088 4.34177 4.89386 GeneID:4665,Genbank:NM_005967.3,HGNC:HGNC:7627,MIM:602381 NGFI-A binding protein 2 GO:0001958,GO:0003714,GO:0005634,GO:0006351,GO:0007399,GO:0008134,GO:0008283,GO:0014037,GO:0016480,GO:0042552,GO:0042802,GO:0045682,GO:1902949 endochondral ossification|transcription corepressor activity|nucleus|transcription, DNA-templated|nervous system development|transcription factor binding|cell proliferation|Schwann cell differentiation|negative regulation of transcription from RNA polymerase III promoter|myelination|identical protein binding|regulation of epidermis development|positive regulation of tau-protein kinase activity NABP1 265.576579219931 275.241538106385 255.911620333477 0.929771073414666 -0.105052552758578 0.661444911855349 1 1.95409 1.73775 1.84065 1.50015 GeneID:64859,Genbank:NM_001254736.1,HGNC:HGNC:26232,MIM:612103 nucleic acid binding protein 1 GO:0000724,GO:0000784,GO:0003697,GO:0003723,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0007093,GO:0010212,GO:0042795,GO:0070876 double-strand break repair via homologous recombination|nuclear chromosome, telomeric region|single-stranded DNA binding|RNA binding|nucleus|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|mitotic cell cycle checkpoint|response to ionizing radiation|snRNA transcription from RNA polymerase II promoter|SOSS complex NABP2 2175.78425418902 2124.79629999591 2226.77220838213 1.04799326334784 0.0676294430529394 0.641106353078244 1 32.6289 33.9043 34.5494 35.5305 GeneID:79035,Genbank:XM_024449184.1,HGNC:HGNC:28412,MIM:612104 nucleic acid binding protein 2 GO:0000724,GO:0000784,GO:0003697,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0007093,GO:0010212,GO:0042795,GO:0070182,GO:0070200,GO:0070876,GO:0098505,GO:1904355 double-strand break repair via homologous recombination|nuclear chromosome, telomeric region|single-stranded DNA binding|nucleus|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|mitotic cell cycle checkpoint|response to ionizing radiation|snRNA transcription from RNA polymerase II promoter|DNA polymerase binding|establishment of protein localization to telomere|SOSS complex|G-rich strand telomeric DNA binding|positive regulation of telomere capping NACA 4822.74193070016 5081.36649091957 4564.11737048075 0.898206688818225 -0.154880629183869 0.251868171521285 1 12.994 11.4298 11.1837 11.1721 GeneID:4666,Genbank:XM_006719412.1,HGNC:HGNC:7629,MIM:601234 nascent polypeptide-associated complex alpha subunit GO:0003231,GO:0003677,GO:0003713,GO:0005634,GO:0005737,GO:0005854,GO:0006351,GO:0006412,GO:0010664,GO:0015031,GO:0016032,GO:0043403,GO:0048633,GO:0048742,GO:0061384,GO:0070062,GO:1901227,GO:1901228,GO:2000138 cardiac ventricle development|DNA binding|transcription coactivator activity|nucleus|cytoplasm|nascent polypeptide-associated complex|transcription, DNA-templated|translation|negative regulation of striated muscle cell apoptotic process|protein transport|viral process|skeletal muscle tissue regeneration|positive regulation of skeletal muscle tissue growth|regulation of skeletal muscle fiber development|heart trabecula morphogenesis|extracellular exosome|negative regulation of transcription from RNA polymerase II promoter involved in heart development|positive regulation of transcription from RNA polymerase II promoter involved in heart development|positive regulation of cell proliferation involved in heart morphogenesis hsa04928 Parathyroid hormone synthesis, secretion and action NACA2 5.91776617344932 5.53486424558581 6.30066810131283 1.13836000699344 0.186956882924206 0.973444828519953 1 0.143586 0.357116 0.317703 0.253405 GeneID:342538,Genbank:NM_199290.3,HGNC:HGNC:23290,MIM:609274 nascent polypeptide associated complex alpha subunit 2 GO:0005634,GO:0005854,GO:0015031 nucleus|nascent polypeptide-associated complex|protein transport NACAD 244.647728234215 238.766565954294 250.528890514135 1.04926286271627 0.069376149059636 0.806437642923857 1 1.36716 1.63638 1.49754 1.77376 GeneID:23148,Genbank:XM_006715674.3,HGNC:HGNC:22196 NAC alpha domain containing GO:0005634,GO:0005854,GO:0015031 nucleus|nascent polypeptide-associated complex|protein transport NACC1 5213.73895922581 4648.71634158894 5778.76157686269 1.2430875863868 0.313927950448473 0.0193109534101506 0.567967248609484 42.8386 43.5881 56.3856 53.2211 GeneID:112939,Genbank:XM_005259721.3,HGNC:HGNC:20967,MIM:610672 nucleus accumbens associated 1 NACC2 2768.41251489847 2417.88333932746 3118.94169046948 1.28994713671215 0.367311943814481 0.00798942446617282 0.352503091598413 17.4074 18.2284 23.1032 24.0682 GeneID:138151,Genbank:NM_144653.4,HGNC:HGNC:23846,MIM:615786 NACC family member 2 GO:0000790,GO:0000978,GO:0001076,GO:0001078,GO:0004407,GO:0005634,GO:0005730,GO:0005739,GO:0006351,GO:0008284,GO:0008285,GO:0010608,GO:0016604,GO:0034629,GO:0042803,GO:0042826,GO:0045892,GO:0051260,GO:1900477,GO:1902231 nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II transcription factor binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|histone deacetylase activity|nucleus|nucleolus|mitochondrion|transcription, DNA-templated|positive regulation of cell proliferation|negative regulation of cell proliferation|posttranscriptional regulation of gene expression|nuclear body|cellular protein complex localization|protein homodimerization activity|histone deacetylase binding|negative regulation of transcription, DNA-templated|protein homooligomerization|negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage NADK 2583.16466012178 2525.07165518461 2641.25766505894 1.04601295556733 0.0649007204347455 0.650131935832748 1 18.2997 18.5796 20.5421 19.4599 GeneID:65220,Genbank:XM_006710839.2,HGNC:HGNC:29831,MIM:611616 NAD kinase GO:0003951,GO:0005524,GO:0005829,GO:0006741,GO:0016310,GO:0019674,GO:0046034,GO:0046872 NAD+ kinase activity|ATP binding|cytosol|NADP biosynthetic process|phosphorylation|NAD metabolic process|ATP metabolic process|metal ion binding hsa00760 Nicotinate and nicotinamide metabolism NADK2 590.05331416084 613.999236367633 566.107391954048 0.922000156389593 -0.11716109952291 0.551540669905071 1 6.22052 5.76104 6.19672 4.69846 GeneID:133686,Genbank:NM_153013.4,HGNC:HGNC:26404,MIM:615787 NAD kinase 2, mitochondrial GO:0003951,GO:0005524,GO:0005739,GO:0005759,GO:0006741,GO:0019674,GO:0042803 NAD+ kinase activity|ATP binding|mitochondrion|mitochondrial matrix|NADP biosynthetic process|NAD metabolic process|protein homodimerization activity hsa00760 Nicotinate and nicotinamide metabolism NADSYN1 579.706024220639 511.01964937425 648.392399067027 1.26882087579409 0.343488412879667 0.0415810818170356 0.762843764469236 6.64214 6.45521 8.12966 9.07501 GeneID:55191,Genbank:NM_018161.4,HGNC:HGNC:29832,MIM:608285 NAD synthetase 1 GO:0003952,GO:0004359,GO:0005524,GO:0005737,GO:0005829,GO:0009435,GO:0019674 NAD+ synthase (glutamine-hydrolyzing) activity|glutaminase activity|ATP binding|cytoplasm|cytosol|NAD biosynthetic process|NAD metabolic process hsa00760 Nicotinate and nicotinamide metabolism NAE1 860.417847707544 934.729136960081 786.106558455007 0.840999309181242 -0.249823479473774 0.265841317478972 1 16.757 12.9952 13.8789 11.8503 GeneID:8883,Genbank:XM_005256215.1,HGNC:HGNC:621,MIM:603385 NEDD8 activating enzyme E1 subunit 1 GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0019781,GO:0031625,GO:0033314,GO:0042981,GO:0043523,GO:0043687,GO:0045116,GO:0046982,GO:0051402 cytoplasm|cytosol|plasma membrane|signal transduction|NEDD8 activating enzyme activity|ubiquitin protein ligase binding|mitotic DNA replication checkpoint|regulation of apoptotic process|regulation of neuron apoptotic process|post-translational protein modification|protein neddylation|protein heterodimerization activity|neuron apoptotic process hsa05010 Alzheimer disease NAF1 371.59968110443 410.268888326591 332.93047388227 0.81149334827759 -0.301348825679445 0.10664906102586 1 2.44606 2.73443 2.09943 2.17717 GeneID:92345,Genbank:XM_011532410.3,HGNC:HGNC:25126,MIM:617868 nuclear assembly factor 1 ribonucleoprotein GO:0000454,GO:0000493,GO:0003723,GO:0005634,GO:0005732,GO:0005737,GO:0032212,GO:0042254,GO:0043489,GO:0051973,GO:0070034,GO:0090669,GO:1904358,GO:1904874,GO:1905323 snoRNA guided rRNA pseudouridine synthesis|box H/ACA snoRNP assembly|RNA binding|nucleus|small nucleolar ribonucleoprotein complex|cytoplasm|positive regulation of telomere maintenance via telomerase|ribosome biogenesis|RNA stabilization|positive regulation of telomerase activity|telomerase RNA binding|telomerase RNA stabilization|positive regulation of telomere maintenance via telomere lengthening|positive regulation of telomerase RNA localization to Cajal body|telomerase holoenzyme complex assembly NAGA 1074.35355766135 940.545401201233 1208.16171412147 1.28453311512495 0.36124408324046 0.0174193076587592 0.545445222117836 10.1557 10.4158 13.5375 13.1452 GeneID:4668,Genbank:NM_000262.2,HGNC:HGNC:7631,MIM:104170 alpha-N-acetylgalactosaminidase GO:0004557,GO:0005737,GO:0005764,GO:0008456,GO:0009311,GO:0016052,GO:0016139,GO:0019377,GO:0042803,GO:0046477,GO:0070062 alpha-galactosidase activity|cytoplasm|lysosome|alpha-N-acetylgalactosaminidase activity|oligosaccharide metabolic process|carbohydrate catabolic process|glycoside catabolic process|glycolipid catabolic process|protein homodimerization activity|glycosylceramide catabolic process|extracellular exosome hsa00603,hsa04142 Glycosphingolipid biosynthesis - globo and isoglobo series|Lysosome NAGK 759.667836197933 743.924975815272 775.410696580594 1.04232378504407 0.0598035026805944 0.729524033856745 1 8.7636 9.34634 9.60941 8.92529 GeneID:55577,Genbank:NM_017567.4,HGNC:HGNC:17174,MIM:606828 N-acetylglucosamine kinase GO:0005524,GO:0005829,GO:0006044,GO:0006048,GO:0006051,GO:0019262,GO:0045127,GO:0070062 ATP binding|cytosol|N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylmannosamine metabolic process|N-acetylneuraminate catabolic process|N-acetylglucosamine kinase activity|extracellular exosome hsa00520 Amino sugar and nucleotide sugar metabolism NAGLU 1125.3773366587 1053.73126074231 1197.02341257508 1.13598548052169 0.18394439530631 0.231236722135166 1 10.1876 11.1725 12.2192 12.2395 GeneID:4669,Genbank:XM_024450771.1,HGNC:HGNC:7632,MIM:609701 N-acetyl-alpha-glucosaminidase GO:0004561,GO:0005764,GO:0006027,GO:0007040,GO:0007399,GO:0021680,GO:0042474,GO:0043202,GO:0045475,GO:0046548,GO:0060119,GO:0070062 alpha-N-acetylglucosaminidase activity|lysosome|glycosaminoglycan catabolic process|lysosome organization|nervous system development|cerebellar Purkinje cell layer development|middle ear morphogenesis|lysosomal lumen|locomotor rhythm|retinal rod cell development|inner ear receptor cell development|extracellular exosome hsa00531,hsa04142 Glycosaminoglycan degradation|Lysosome NAGPA 258.975533351767 255.793586508108 262.157480195426 1.02487901973694 0.0354536190705578 0.889286441549447 1 4.75773 5.29093 4.6063 5.65752 GeneID:51172,Genbank:NM_016256.3,HGNC:HGNC:17378,MIM:607985 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase GO:0003944,GO:0005887,GO:0005975,GO:0006464,GO:0006486,GO:0006622,GO:0007040,GO:0016021,GO:0032580,GO:0033299 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity|integral component of plasma membrane|carbohydrate metabolic process|cellular protein modification process|protein glycosylation|protein targeting to lysosome|lysosome organization|integral component of membrane|Golgi cisterna membrane|secretion of lysosomal enzymes hsa04142 Lysosome NAGS 42.1179238310894 33.3532642975697 50.8825833646092 1.5255653213025 0.609343954221133 0.183830596060659 1 0.3357 0.766464 0.856618 0.954554 GeneID:162417,Genbank:XM_011524438.1,HGNC:HGNC:17996,MIM:608300 N-acetylglutamate synthase hsa00220 Arginine biosynthesis NAIF1 368.273909893573 368.748106330017 367.799713457128 0.997428073916563 -0.00371528477564613 0.983066112106968 1 4.29463 4.20472 3.85699 4.56528 GeneID:203245,Genbank:NM_197956.3,HGNC:HGNC:25446,MIM:610673 nuclear apoptosis inducing factor 1 GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0005886,GO:0030308,GO:1902108 nucleus|nucleoplasm|mitochondrion|cytosol|plasma membrane|negative regulation of cell growth|regulation of mitochondrial membrane permeability involved in apoptotic process NAIP 5.01847238869739 5.18887166768327 4.84807310971151 0.934321259071739 -0.0980094002214743 1 1 0.0339424 0.026835 0.037974 0.010101 GeneID:4671,Genbank:NM_022892.1,HGNC:HGNC:7634,MIM:600355 NLR family apoptosis inhibitory protein GO:0004842,GO:0005524,GO:0005634,GO:0005737,GO:0006954,GO:0007399,GO:0016323,GO:0043005,GO:0043027,GO:0043066,GO:0043154,GO:0043200,GO:0043204,GO:0043524,GO:0045087,GO:0046872,GO:0048678,GO:0070062,GO:0090263,GO:1990001 ubiquitin-protein transferase activity|ATP binding|nucleus|cytoplasm|inflammatory response|nervous system development|basolateral plasma membrane|neuron projection|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to amino acid|perikaryon|negative regulation of neuron apoptotic process|innate immune response|metal ion binding|response to axon injury|extracellular exosome|positive regulation of canonical Wnt signaling pathway|inhibition of cysteine-type endopeptidase activity involved in apoptotic process hsa04621,hsa05134 NOD-like receptor signaling pathway|Legionellosis NALCN 12.3568807813236 9.20549543271206 15.5082661299351 1.68467479488675 0.752470124294327 0.376562174982235 1 0.0459719 0.0485573 0.0549242 0.0561146 GeneID:259232,Genbank:XM_011521067.2,HGNC:HGNC:19082,MIM:611549 sodium leak channel, non-selective GO:0005244,GO:0005261,GO:0005272,GO:0005886,GO:0006816,GO:0016021,GO:0022840,GO:0034220,GO:0034765,GO:0035725,GO:0060075,GO:0070588,GO:0071805,GO:0086010 voltage-gated ion channel activity|cation channel activity|sodium channel activity|plasma membrane|calcium ion transport|integral component of membrane|leak channel activity|ion transmembrane transport|regulation of ion transmembrane transport|sodium ion transmembrane transport|regulation of resting membrane potential|calcium ion transmembrane transport|potassium ion transmembrane transport|membrane depolarization during action potential NAMPT 1167.73568538019 1242.52711000461 1092.94426075576 0.879614015626356 -0.185057502843703 0.330150763007181 1 11.7069 11.1114 11.0958 8.72269 GeneID:10135,Genbank:NM_005746.2,HGNC:HGNC:30092,MIM:608764 nicotinamide phosphoribosyltransferase hsa00760,hsa04621 Nicotinate and nicotinamide metabolism|NOD-like receptor signaling pathway NANOGP8 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0213864 0 0 0 GeneID:388112,Genbank:NM_001355281.1,HGNC:HGNC:23106 Nanog homeobox retrogene P8 GO:0005634,GO:0006351,GO:0006355,GO:0008284,GO:0043565,GO:1902808 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of cell proliferation|sequence-specific DNA binding|positive regulation of cell cycle G1/S phase transition NANOS1 92.0606455332031 81.8693160904938 102.251974975912 1.24896578912286 0.320733960101394 0.307995790430737 1 0.956842 1.08509 1.22781 1.32019 GeneID:340719,Genbank:NM_199461.3,HGNC:HGNC:23044,MIM:608226 nanos C2HC-type zinc finger 1 GO:0001558,GO:0001894,GO:0003723,GO:0005737,GO:0008270,GO:0010608,GO:0010631,GO:0016477,GO:0017148,GO:0030371,GO:0048471,GO:0098749,GO:1900153 regulation of cell growth|tissue homeostasis|RNA binding|cytoplasm|zinc ion binding|posttranscriptional regulation of gene expression|epithelial cell migration|cell migration|negative regulation of translation|translation repressor activity|perinuclear region of cytoplasm|cerebellar neuron development|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay NANOS3 8.40820982283909 9.06141660865723 7.75500303702094 0.855826784259301 -0.22460926412251 0.857061468057563 1 0.318496 0.54062 0.290981 0.108986 GeneID:342977,Genbank:NM_001098622.2,HGNC:HGNC:22048,MIM:608229 nanos C2HC-type zinc finger 3 GO:0000932,GO:0003723,GO:0005634,GO:0005737,GO:0006417,GO:0007275,GO:0007281,GO:0007283,GO:0008270,GO:0010494,GO:0017148,GO:0048471,GO:0048477,GO:0051726,GO:1900153,GO:2001234 P-body|RNA binding|nucleus|cytoplasm|regulation of translation|multicellular organism development|germ cell development|spermatogenesis|zinc ion binding|cytoplasmic stress granule|negative regulation of translation|perinuclear region of cytoplasm|oogenesis|regulation of cell cycle|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of apoptotic signaling pathway NANP 226.254663034172 264.931438355919 187.577887712424 0.708024268001085 -0.49812928440283 0.023015224001728 0.613948474678957 3.22714 3.2567 2.7516 1.87397 GeneID:140838,Genbank:NM_152667.2,HGNC:HGNC:16140,MIM:610763 N-acetylneuraminic acid phosphatase GO:0005829,GO:0005975,GO:0006045,GO:0046380,GO:0050124 cytosol|carbohydrate metabolic process|N-acetylglucosamine biosynthetic process|N-acetylneuraminate biosynthetic process|N-acylneuraminate-9-phosphatase activity hsa00520 Amino sugar and nucleotide sugar metabolism NANS 1148.74143513125 1161.05384676841 1136.42902349409 0.978790972233665 -0.0309272999410303 0.837265847246334 1 12.1013 13.313 12.6489 12.5329 GeneID:54187,Genbank:NM_018946.3,HGNC:HGNC:19237,MIM:605202 N-acetylneuraminate synthase GO:0005737,GO:0005829,GO:0006055,GO:0008781,GO:0016051,GO:0047444,GO:0050462,GO:0070062 cytoplasm|cytosol|CMP-N-acetylneuraminate biosynthetic process|N-acylneuraminate cytidylyltransferase activity|carbohydrate biosynthetic process|N-acylneuraminate-9-phosphate synthase activity|N-acetylneuraminate synthase activity|extracellular exosome hsa00520 Amino sugar and nucleotide sugar metabolism NAP1L1 4750.04443872772 5014.57742508015 4485.51145237529 0.894494405439078 -0.160855635830457 0.371436497942246 1 28.0161 24.1909 25.6411 21.3302 GeneID:4673,Genbank:NM_001330232.1,HGNC:HGNC:7637,MIM:164060 nucleosome assembly protein 1 like 1 GO:0003723,GO:0005634,GO:0006260,GO:0006334,GO:0008284,GO:0016020,GO:0042470 RNA binding|nucleus|DNA replication|nucleosome assembly|positive regulation of cell proliferation|membrane|melanosome NAP1L2 8.51620274715266 6.85119097229513 10.1812145220102 1.48605031784707 0.571482966535608 0.610993838735862 1 0.172805 0.0501965 0.251378 0.0932214 GeneID:4674,Genbank:NM_021963.3,HGNC:HGNC:7638,MIM:300026 nucleosome assembly protein 1 like 2 GO:0003682,GO:0005634,GO:0006334,GO:0042393,GO:0045666,GO:0071442,GO:2000035,GO:2000617 chromatin binding|nucleus|nucleosome assembly|histone binding|positive regulation of neuron differentiation|positive regulation of histone H3-K14 acetylation|regulation of stem cell division|positive regulation of histone H3-K9 acetylation NAP1L3 1.78228621950799 2.59443583384164 0.97013660517434 0.373929696976871 -1.41916104230609 0.670772680940795 1 0.0464926 0.0297961 0.0298349 0 GeneID:4675,Genbank:NM_004538.5,HGNC:HGNC:7639,MIM:300117 nucleosome assembly protein 1 like 3 GO:0005634,GO:0006334 nucleus|nucleosome assembly NAP1L4 3358.68397196785 3465.03769008706 3252.33025384863 0.938613240240659 -0.0913972834719501 0.50428799878261 1 45.1322 44.9715 43.5512 41.6162 GeneID:4676,Genbank:NM_005969.3,HGNC:HGNC:7640,MIM:601651 nucleosome assembly protein 1 like 4 GO:0003723,GO:0005634,GO:0005737,GO:0006334,GO:0031491,GO:0051082 RNA binding|nucleus|cytoplasm|nucleosome assembly|nucleosome binding|unfolded protein binding NAP1L5 174.858333220083 181.553690439976 168.16297600019 0.926243777213586 -0.110536149898858 0.651770505306415 1 3.02067 3.13176 2.88567 2.85338 GeneID:266812,Genbank:NM_153757.3,HGNC:HGNC:19968,MIM:612203 nucleosome assembly protein 1 like 5 GO:0005634,GO:0006334 nucleus|nucleosome assembly NAPA 4173.30792025122 3758.04931118032 4588.56652932212 1.2209968921033 0.288059528128051 0.0324566337061183 0.713066454646352 69.6636 68.8351 90.4241 82.3178 GeneID:8775,Genbank:NM_003827.3,HGNC:HGNC:7641,MIM:603215 NSF attachment protein alpha GO:0000139,GO:0000149,GO:0005483,GO:0005774,GO:0005829,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0006891,GO:0007420,GO:0010807,GO:0016020,GO:0019905,GO:0030182,GO:0031201,GO:0032403,GO:0032781,GO:0035249,GO:0035494,GO:0043195,GO:0043209,GO:0045176,GO:0048208,GO:0061025,GO:0070044,GO:0070062 Golgi membrane|SNARE binding|soluble NSF attachment protein activity|vacuolar membrane|cytosol|plasma membrane|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|brain development|regulation of synaptic vesicle priming|membrane|syntaxin binding|neuron differentiation|SNARE complex|protein complex binding|positive regulation of ATPase activity|synaptic transmission, glutamatergic|SNARE complex disassembly|terminal bouton|myelin sheath|apical protein localization|COPII vesicle coating|membrane fusion|synaptobrevin 2-SNAP-25-syntaxin-1a complex|extracellular exosome hsa04721 Synaptic vesicle cycle NAPB 237.956552083863 258.310570101941 217.602534065785 0.842406619210005 -0.247411322502921 0.260527463370805 1 2.81859 2.59474 2.51 2.18566 GeneID:63908,Genbank:NM_001283020.1,HGNC:HGNC:15751,MIM:611270 NSF attachment protein beta GO:0005483,GO:0005774,GO:0006886,GO:0019905,GO:0031201,GO:0035494,GO:0061025,GO:0070062 soluble NSF attachment protein activity|vacuolar membrane|intracellular protein transport|syntaxin binding|SNARE complex|SNARE complex disassembly|membrane fusion|extracellular exosome NAPEPLD 323.049749257233 331.070443309093 315.029055205374 0.951546903603407 -0.0716533233819969 0.732718751591811 1 2.01429 1.80982 2.05 1.70378 GeneID:222236,Genbank:NM_198990.4,HGNC:HGNC:21683,MIM:612334 N-acyl phosphatidylethanolamine phospholipase D hsa04723 Retrograde endocannabinoid signaling NAPG 730.365769724511 793.362318481463 667.369220967558 0.841190973431833 -0.249494725862607 0.125119997619894 1 8.07717 7.6187 7.30471 6.09058 GeneID:8774,Genbank:NM_003826.2,HGNC:HGNC:7642,MIM:603216 NSF attachment protein gamma GO:0005483,GO:0005739,GO:0005765,GO:0006461,GO:0006886,GO:0006891,GO:0019905,GO:0031201,GO:0043209,GO:0050821,GO:0061025,GO:0070062 soluble NSF attachment protein activity|mitochondrion|lysosomal membrane|protein complex assembly|intracellular protein transport|intra-Golgi vesicle-mediated transport|syntaxin binding|SNARE complex|myelin sheath|protein stabilization|membrane fusion|extracellular exosome NAPRT 40.5190879914946 37.9079857392408 43.1301902437485 1.13776001026353 0.186196279511136 0.738992621191717 1 0.371498 0.675407 0.651464 0.663751 GeneID:93100,Genbank:XM_024447333.1,HGNC:HGNC:30450,MIM:611552 nicotinate phosphoribosyltransferase GO:0004514,GO:0004516,GO:0005576,GO:0005829,GO:0006979,GO:0019358,GO:0034356,GO:0035578,GO:0043312,GO:0070062 nicotinate-nucleotide diphosphorylase (carboxylating) activity|nicotinate phosphoribosyltransferase activity|extracellular region|cytosol|response to oxidative stress|nicotinate nucleotide salvage|NAD biosynthesis via nicotinamide riboside salvage pathway|azurophil granule lumen|neutrophil degranulation|extracellular exosome hsa00760 Nicotinate and nicotinamide metabolism NAPSA 4.17469662149089 1.56626675524197 6.78312648773981 4.33076068622288 2.11462045263209 0.191965374891507 1 0.0477603 0.0212531 0.067056 0.0834988 GeneID:9476,Genbank:XM_017027512.1,HGNC:HGNC:13395,MIM:605631 napsin A aspartic peptidase GO:0004175,GO:0004190,GO:0005615,GO:0005764,GO:0006508,GO:0006914,GO:0008233,GO:0030163,GO:0033619,GO:0043129,GO:0044267,GO:0070062,GO:0097208,GO:0097486 endopeptidase activity|aspartic-type endopeptidase activity|extracellular space|lysosome|proteolysis|autophagy|peptidase activity|protein catabolic process|membrane protein proteolysis|surfactant homeostasis|cellular protein metabolic process|extracellular exosome|alveolar lamellar body|multivesicular body lumen hsa04142 Lysosome NARF 1595.99175562425 1494.93248232201 1697.05102892649 1.13520245830136 0.182949618696563 0.301904610375407 1 5.89267 6.87582 7.02484 8.00776 GeneID:26502,Genbank:NM_001038618.2,HGNC:HGNC:29916,MIM:605349 nuclear prelamin A recognition factor GO:0003954,GO:0005521,GO:0005634,GO:0005638,GO:0005652,GO:0005730,GO:0031981 NADH dehydrogenase activity|lamin binding|nucleus|lamin filament|nuclear lamina|nucleolus|nuclear lumen NARFL 599.278190440497 577.754586933858 620.801793947136 1.07450777196202 0.103675917880178 0.537082851876044 1 10.0873 9.92993 11.3716 11.1627 GeneID:64428,Genbank:NM_022493.2,HGNC:HGNC:14179,MIM:611118 nuclear prelamin A recognition factor like GO:0001666,GO:0002244,GO:0003954,GO:0010468,GO:0016226,GO:0032364,GO:0046872,GO:0051536,GO:0051539,GO:0097361 response to hypoxia|hematopoietic progenitor cell differentiation|NADH dehydrogenase activity|regulation of gene expression|iron-sulfur cluster assembly|oxygen homeostasis|metal ion binding|iron-sulfur cluster binding|4 iron, 4 sulfur cluster binding|CIA complex NARS 1817.33070281682 1938.45349739253 1696.20790824112 0.875031518951957 -0.192593110609014 0.185424921971547 1 24.019 21.9479 21.0132 20.1687 GeneID:4677,Genbank:XM_005266700.2,HGNC:HGNC:7643,MIM:108410 asparaginyl-tRNA synthetase GO:0003676,GO:0004816,GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006418,GO:0006421,GO:0070062 nucleic acid binding|asparagine-tRNA ligase activity|ATP binding|cytoplasm|mitochondrion|cytosol|tRNA aminoacylation for protein translation|asparaginyl-tRNA aminoacylation|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis NARS2 425.077745587433 470.229070153058 379.926421021808 0.807960300919173 -0.307643686902969 0.0914154677545976 0.983284171630379 5.92901 6.42896 5.34973 5.81287 GeneID:79731,Genbank:NM_001243251.1,HGNC:HGNC:26274,MIM:612803 asparaginyl-tRNA synthetase 2, mitochondrial GO:0003676,GO:0004816,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006421 nucleic acid binding|asparagine-tRNA ligase activity|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|asparaginyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis NASP 4209.18404362321 4290.69262681961 4127.67546042682 0.962006794573485 -0.0558810112217174 0.699721380517447 1 30.7919 28.428 30.6086 27.4734 GeneID:4678,Genbank:NM_002482.3,HGNC:HGNC:7644,MIM:603185 nuclear autoantigenic sperm protein GO:0000790,GO:0001824,GO:0005634,GO:0005654,GO:0005737,GO:0006260,GO:0006334,GO:0006335,GO:0006336,GO:0007049,GO:0008283,GO:0008584,GO:0015031,GO:0032403,GO:0033574,GO:0042393,GO:0043234,GO:0043486,GO:0051879 nuclear chromatin|blastocyst development|nucleus|nucleoplasm|cytoplasm|DNA replication|nucleosome assembly|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|cell cycle|cell proliferation|male gonad development|protein transport|protein complex binding|response to testosterone|histone binding|protein complex|histone exchange|Hsp90 protein binding NAT1 158.300556635008 170.234021920272 146.367091349743 0.859799290991861 -0.217928174241593 0.392572930579492 1 1.15397 1.15172 1.09377 0.947749 GeneID:9,Genbank:XM_017013947.1,HGNC:HGNC:7645,MIM:108345 N-acetyltransferase 1 hsa00232,hsa00983,hsa05204 Caffeine metabolism|Drug metabolism - other enzymes|Chemical carcinogenesis NAT10 2205.17206823753 2296.93175559336 2113.4123808817 0.920102382552392 -0.120133691780303 0.389185586660884 1 20.9384 20.9742 19.4527 19.5915 GeneID:55226,Genbank:NM_024662.2,HGNC:HGNC:29830,MIM:609221 N-acetyltransferase 10 GO:0000049,GO:0000154,GO:0000784,GO:0002101,GO:0003723,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0008080,GO:0016020,GO:0030496,GO:0030686,GO:0032211,GO:0051391,GO:0051392,GO:0070182,GO:1904812,GO:1990883 tRNA binding|rRNA modification|nuclear chromosome, telomeric region|tRNA wobble cytosine modification|RNA binding|ATP binding|nucleus|nucleoplasm|nucleolus|N-acetyltransferase activity|membrane|midbody|90S preribosome|negative regulation of telomere maintenance via telomerase|tRNA acetylation|tRNA N-acetyltransferase activity|DNA polymerase binding|rRNA acetylation involved in maturation of SSU-rRNA|rRNA cytidine N-acetyltransferase activity hsa03008 Ribosome biogenesis in eukaryotes NAT14 1582.76066797879 1583.31578846115 1582.20554749644 0.999298787410065 -0.00101199077792683 0.980454462231938 1 70.7015 73.2377 69.7705 77.4359 GeneID:57106,Genbank:NM_020378.3,HGNC:HGNC:28918 N-acetyltransferase 14 (putative) GO:0003677,GO:0005634,GO:0006352,GO:0008080,GO:0016021,GO:0045893 DNA binding|nucleus|DNA-templated transcription, initiation|N-acetyltransferase activity|integral component of membrane|positive regulation of transcription, DNA-templated NAT16 0.99578132014851 0.538097676642304 1.45346496365472 2.70111733751434 1.43355631240266 0.835241087836065 1 0.0166737 0 0.0153505 0.0143432 GeneID:375607,Genbank:NM_198571.2,HGNC:HGNC:22030,MIM:615783 N-acetyltransferase 16 (putative) GO:0006473,GO:0008080,GO:0016747 protein acetylation|N-acetyltransferase activity|transferase activity, transferring acyl groups other than amino-acyl groups NAT6 121.111646810253 124.47610209546 117.747191525047 0.945942149078113 -0.080176139430706 0.786657876742726 1 2.9796 3.56574 2.79509 3.58334 GeneID:24142,Genbank:NM_012191.3,HGNC:HGNC:30252,MIM:607073 N-acetyltransferase 6 GO:0005737,GO:0006473,GO:0008080,GO:1905502 cytoplasm|protein acetylation|N-acetyltransferase activity|acetyl-CoA binding NAT8L 421.514001091914 390.377874600187 452.650127583641 1.1595178851958 0.213525073269202 0.241480021621187 1 4.40437 4.06592 5.21508 4.79962 GeneID:339983,Genbank:NM_178557.3,HGNC:HGNC:26742,MIM:610647 N-acetyltransferase 8 like GO:0005737,GO:0005739,GO:0005759,GO:0008652,GO:0016021,GO:0017188,GO:0030867,GO:0031966 cytoplasm|mitochondrion|mitochondrial matrix|cellular amino acid biosynthetic process|integral component of membrane|aspartate N-acetyltransferase activity|rough endoplasmic reticulum membrane|mitochondrial membrane hsa00250 Alanine, aspartate and glutamate metabolism NAT9 776.284363650151 809.199507824116 743.369219476186 0.918647641636679 -0.122416490328402 0.428330439523354 1 7.96866 8.85678 7.76946 8.65229 GeneID:26151,Genbank:NM_001305078.1,HGNC:HGNC:23133 N-acetyltransferase 9 (putative) GO:0008080,GO:0043234 N-acetyltransferase activity|protein complex NATD1 322.463216486189 310.074825264935 334.851607707444 1.07990581764043 0.110905495399814 0.571380512706558 1 2.99336 2.77896 2.92171 3.38326 GeneID:256302,Genbank:NM_152914.2,HGNC:HGNC:30770 N-acetyltransferase domain containing 1 NAV1 941.784417980198 941.851919272834 941.716916687561 0.999856662621257 -0.000206806947423454 0.998522336660662 1 1.95999 1.98409 2.24018 1.75276 GeneID:89796,Genbank:XM_024450645.1,HGNC:HGNC:15989,MIM:611628 neuron navigator 1 GO:0001578,GO:0001764,GO:0005737,GO:0005874,GO:0043194 microtubule bundle formation|neuron migration|cytoplasm|microtubule|axon initial segment NAV2 2305.04940159738 2079.08437244407 2531.01443075069 1.21736975386687 0.283767426926108 0.120826033497799 1 3.2922 3.2345 4.6444 3.44819 GeneID:89797,Genbank:XM_017018522.1,HGNC:HGNC:15997,MIM:607026 neuron navigator 2 GO:0003025,GO:0004386,GO:0005524,GO:0005614,GO:0005654,GO:0007605,GO:0007608,GO:0007626,GO:0008201,GO:0021554,GO:0021563,GO:0021564 regulation of systemic arterial blood pressure by baroreceptor feedback|helicase activity|ATP binding|interstitial matrix|nucleoplasm|sensory perception of sound|sensory perception of smell|locomotory behavior|heparin binding|optic nerve development|glossopharyngeal nerve development|vagus nerve development NAV3 96.2249021361332 112.944711166801 79.5050931054658 0.703929314477152 -0.506497527918512 0.29547251169409 1 0.216757 0.185315 0.196309 0.0894789 GeneID:89795,Genbank:XM_017020166.2,HGNC:HGNC:15998,MIM:611629 neuron navigator 3 GO:0005524,GO:0005640,GO:0007026,GO:0008017,GO:0030336,GO:0031116,GO:0032703,GO:1905929 ATP binding|nuclear outer membrane|negative regulation of microtubule depolymerization|microtubule binding|negative regulation of cell migration|positive regulation of microtubule polymerization|negative regulation of interleukin-2 production|positive regulation of invadopodium disassembly NAXD 831.57729931636 801.012372814896 862.142225817824 1.07631574127639 0.106101360007084 0.515149584113782 1 11.4123 11.4313 13.0845 12.6605 GeneID:55739,Genbank:NM_001242882.1,HGNC:HGNC:25576,MIM:615910 NAD(P)HX dehydratase GO:0005524,GO:0005759,GO:0034356,GO:0047453,GO:0052855 ATP binding|mitochondrial matrix|NAD biosynthesis via nicotinamide riboside salvage pathway|ATP-dependent NAD(P)H-hydrate dehydratase activity|ADP-dependent NAD(P)H-hydrate dehydratase activity NAXE 2262.73873980748 2311.87606302722 2213.60141658774 0.957491386319906 -0.0626685864079422 0.686685913489893 1 13.4091 15.0326 12.9126 14.7383 GeneID:128240,Genbank:NM_144772.2,HGNC:HGNC:18453,MIM:608862 NAD(P)HX epimerase GO:0000166,GO:0005576,GO:0005615,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0005929,GO:0006734,GO:0006739,GO:0034356,GO:0042803,GO:0043231,GO:0044297,GO:0046496,GO:0046872,GO:0051289,GO:0052856,GO:0052857,GO:0070062 nucleotide binding|extracellular region|extracellular space|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|cilium|NADH metabolic process|NADP metabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|protein homodimerization activity|intracellular membrane-bounded organelle|cell body|nicotinamide nucleotide metabolic process|metal ion binding|protein homotetramerization|NADHX epimerase activity|NADPHX epimerase activity|extracellular exosome NBAS 663.939121691753 664.399138529232 663.479104854273 0.998615239512508 -0.00199917159472223 1 1 2.79601 2.68128 2.91082 2.70515 GeneID:51594,Genbank:XM_017004317.1,HGNC:HGNC:15625,MIM:608025 neuroblastoma amplified sequence GO:0000149,GO:0000956,GO:0005783,GO:0005789,GO:0005829,GO:0006890,GO:0015031,GO:0016020,GO:0070939,GO:2000623 SNARE binding|nuclear-transcribed mRNA catabolic process|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|retrograde vesicle-mediated transport, Golgi to ER|protein transport|membrane|Dsl1/NZR complex|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay NBDY 481.961198317337 460.899113206507 503.023283428167 1.09139564172428 0.126174187713314 0.484576307672865 1 2.73628 3.15918 3.04664 3.20827 GeneID:550643,Genbank:NM_001348129.1,HGNC:HGNC:50713,MIM:300992 negative regulator of P-body association GO:0000932,GO:0000956,GO:0006397,GO:0010607 P-body|nuclear-transcribed mRNA catabolic process|mRNA processing|negative regulation of cytoplasmic mRNA processing body assembly NBEA 64.7754943215968 61.69014471598 67.8608439272136 1.10002730970471 0.137539341101273 0.713210696621157 1 0.170391 0.149289 0.189793 0.126341 GeneID:26960,Genbank:XM_005266347.4,HGNC:HGNC:7648,MIM:604889 neurobeachin GO:0005802,GO:0005829,GO:0005886,GO:0008104,GO:0012505,GO:0019901 trans-Golgi network|cytosol|plasma membrane|protein localization|endomembrane system|protein kinase binding NBEAL1 238.45910211032 245.752027095536 231.166177125105 0.940648099050018 -0.0882729901135899 0.678965576121522 1 0.496155 0.592922 0.497324 0.494842 GeneID:65065,Genbank:XM_011511658.3,HGNC:HGNC:20681,MIM:609816 neurobeachin like 1 NBEAL2 799.814996023997 808.708419421304 790.921572626689 0.978005859259704 -0.0320849864587321 0.845771556817173 1 3.04588 2.89086 3.24108 2.86552 GeneID:23218,Genbank:NM_015175.2,HGNC:HGNC:31928,MIM:614169 neurobeachin like 2 GO:0005783,GO:0005886,GO:0016020,GO:0030220,GO:0043312,GO:0070821,GO:0101003 endoplasmic reticulum|plasma membrane|membrane|platelet formation|neutrophil degranulation|tertiary granule membrane|ficolin-1-rich granule membrane NBL1 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 1.26278e-06 0.0457589 1.26626e-06 0.0462992 GeneID:4681,Genbank:NM_182744.3,HGNC:HGNC:7650,MIM:600613 neuroblastoma 1, DAN family BMP antagonist GO:0005615,GO:0007399,GO:0016015,GO:0030514,GO:0035582,GO:0036122,GO:0038098,GO:0042803,GO:0045666,GO:0048263,GO:0048812,GO:0090027 extracellular space|nervous system development|morphogen activity|negative regulation of BMP signaling pathway|sequestering of BMP in extracellular matrix|BMP binding|sequestering of BMP from receptor via BMP binding|protein homodimerization activity|positive regulation of neuron differentiation|determination of dorsal identity|neuron projection morphogenesis|negative regulation of monocyte chemotaxis hsa04350 TGF-beta signaling pathway NBN 374.741520700361 384.467591811374 365.015449589348 0.94940498851833 -0.0749044646568311 0.869166927039391 1 2.24359 2.18945 2.66539 1.46478 GeneID:4683,Genbank:NM_001024688.2,HGNC:HGNC:7652,MIM:602667 nibrin hsa03440,hsa04218 Homologous recombination|Cellular senescence NBPF1 1201.87580523005 1321.07382148759 1082.67778897252 0.819543746429989 -0.287107133880964 0.0527447929875717 0.839722270863765 4.83016 5.25191 4.52268 4.17121 GeneID:55672,Genbank:NM_017940.4,HGNC:HGNC:26088,MIM:610501 NBPF member 1 GO:0005737 cytoplasm NBPF10 42.6724570365923 41.7226957504218 43.6222183227628 1.04552732123791 0.0642307622617186 0.933737484828676 1 0.0208104 0.0437394 0.0556743 0.0310596 GeneID:100132406,Genbank:NM_001039703.5,HGNC:HGNC:31992,MIM:614000 NBPF member 10 GO:0005737 cytoplasm NBPF11 152.783509147325 164.045390138458 141.521628156192 0.862697988872128 -0.213072502127043 0.52298989035482 1 0.902257 0.730218 0.764318 0.638757 GeneID:200030,Genbank:NM_183372.5,HGNC:HGNC:31993,MIM:614001 NBPF member 11 GO:0005737 cytoplasm NBPF12 253.039034197811 239.035106292188 267.042962103434 1.11717047025306 0.15984934501898 0.452718365094969 1 0.714926 0.683508 0.933014 0.737805 GeneID:149013,Genbank:NM_001278141.1,HGNC:HGNC:24297,MIM:608607 NBPF member 12 GO:0005737 cytoplasm NBPF14 190.478740099253 189.509485730025 191.447994468481 1.01022908553093 0.0146824841488045 0.935676249903674 1 0.416559 0.33785 0.357449 0.340043 GeneID:25832,Genbank:NM_015383.2,HGNC:HGNC:25232,MIM:614003 NBPF member 14 GO:0005737 cytoplasm NBPF15 573.947690102614 587.661876177484 560.233504027745 0.953326269302767 -0.0689580438709442 0.679521297419053 1 2.66829 2.87577 2.80077 2.76162 GeneID:284565,Genbank:NM_001170755.2,HGNC:HGNC:28791,MIM:614005 NBPF member 15 GO:0005737 cytoplasm NBPF19 183.00714976281 186.204464431017 179.809835094602 0.965658023528302 -0.0504157289212553 0.841225413397669 1 0.292751 0.27187 0.302349 0.251535 GeneID:101060226,Genbank:NM_001351365.1,HGNC:HGNC:31999,MIM:614006 NBPF member 19 GO:0005737 cytoplasm NBPF20 39.7051143588424 43.5290938790885 35.8811348385962 0.824302360583564 -0.278754468520978 0.726853022797589 1 0.0492017 0.0465137 0.0738389 0.0181553 GeneID:100288142,Genbank:NM_001278267.1,HGNC:HGNC:32000,MIM:614007 NBPF member 20 GO:0005737 cytoplasm NBPF26 90.2574393917828 92.2950857005453 88.2197930830203 0.955844966320879 -0.065151456239795 0.849054752515512 1 0.719764 0.633041 0.715541 0.441926 GeneID:101060684,Genbank:NM_001351372.1,HGNC:HGNC:49571 NBPF member 26 GO:0005737 cytoplasm NBPF3 214.684760315816 213.715089524676 215.654431106956 1.00907442514515 0.0130325855721576 0.956799491561963 1 0.982291 0.904099 1.00062 0.960174 GeneID:84224,Genbank:XM_011542281.1,HGNC:HGNC:25076,MIM:612992 NBPF member 3 GO:0005737,GO:1903955 cytoplasm|positive regulation of protein targeting to mitochondrion NBPF8 595.2829830039 612.837814120941 577.728151886859 0.942709699980828 -0.0851145221595324 0.602742392858853 1 2.33416 2.61038 2.44431 1.91629 GeneID:728841,Genbank:NM_001037501.3,HGNC:HGNC:31990,MIM:613998 NBPF member 8 GO:0005737 cytoplasm NBPF9 474.275033582776 489.073314491501 459.47675267405 0.939484406651336 -0.090058878567719 0.625914456211484 1 2.23717 2.77769 2.69867 1.9808 GeneID:400818,Genbank:NM_001037675.3,HGNC:HGNC:31991,MIM:613999 NBPF member 9 GO:0005737 cytoplasm NBR1 2641.13084594229 2640.48328966885 2641.77840221572 1.00049048314448 0.000707444119653691 0.986745888777284 1 12.9224 12.791 13.9635 12.4837 GeneID:4077,Genbank:XM_024450749.1,HGNC:HGNC:6746,MIM:166945 NBR1, autophagy cargo receptor GO:0000407,GO:0005654,GO:0005764,GO:0005770,GO:0005776,GO:0005829,GO:0008270,GO:0016020,GO:0016236,GO:0016604,GO:0030500,GO:0031430,GO:0032872,GO:0043130,GO:0043231,GO:0045668,GO:0051019,GO:0051259,GO:0070062 phagophore assembly site|nucleoplasm|lysosome|late endosome|autophagosome|cytosol|zinc ion binding|membrane|macroautophagy|nuclear body|regulation of bone mineralization|M band|regulation of stress-activated MAPK cascade|ubiquitin binding|intracellular membrane-bounded organelle|negative regulation of osteoblast differentiation|mitogen-activated protein kinase binding|protein oligomerization|extracellular exosome hsa04137 Mitophagy - animal NCALD 11.9442868767905 9.34957425676688 14.5389994968141 1.55504401564503 0.636955416532142 0.452777563630159 1 0.0520532 0.0178387 0.0678706 0.0590398 GeneID:83988,Genbank:NM_001040630.1,HGNC:HGNC:7655,MIM:606722 neurocalcin delta GO:0003073,GO:0003779,GO:0005509,GO:0005622,GO:0005829,GO:0015276,GO:0015631,GO:0016192,GO:0019722,GO:0030130,GO:0030276,GO:0043014,GO:0070062 regulation of systemic arterial blood pressure|actin binding|calcium ion binding|intracellular|cytosol|ligand-gated ion channel activity|tubulin binding|vesicle-mediated transport|calcium-mediated signaling|clathrin coat of trans-Golgi network vesicle|clathrin binding|alpha-tubulin binding|extracellular exosome hsa04740 Olfactory transduction NCAM1 1236.83645057515 1026.44994136612 1447.22295978419 1.40993038380231 0.495623930409424 0.000838937420395125 0.0905241727626952 3.76246 3.77653 5.99714 4.74076 GeneID:4684,Genbank:NM_001242607.1,HGNC:HGNC:7656,MIM:116930 neural cell adhesion molecule 1 hsa04514,hsa05020 Cell adhesion molecules (CAMs)|Prion diseases NCAN 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00541396 0 GeneID:1463,Genbank:NM_004386.2,HGNC:HGNC:2465,MIM:600826 neurocan NCAPD2 6140.01452922811 5943.87217970087 6336.15687875534 1.06599817209969 0.092204964265034 0.491731164103152 1 40.2209 41.3057 46.1739 42.2239 GeneID:9918,Genbank:NM_014865.3,HGNC:HGNC:24305,MIM:615638 non-SMC condensin I complex subunit D2 GO:0000779,GO:0000793,GO:0000796,GO:0000797,GO:0000799,GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007076,GO:0010032,GO:0016020,GO:0042393,GO:0051301,GO:0051304 condensed chromosome, centromeric region|condensed chromosome|condensin complex|condensin core heterodimer|nuclear condensin complex|chromatin binding|nucleus|nucleoplasm|cytoplasm|cytosol|mitotic chromosome condensation|meiotic chromosome condensation|membrane|histone binding|cell division|chromosome separation NCAPD3 2529.92804071074 2552.79095168466 2507.06512973682 0.982087909737508 -0.0260759244554967 0.862344802285934 1 15.5592 14.998 16.1101 14.1791 GeneID:23310,Genbank:XM_024448406.1,HGNC:HGNC:28952,MIM:609276 non-SMC condensin II complex subunit D3 GO:0000779,GO:0000799,GO:0003682,GO:0005654,GO:0007076,GO:0010032,GO:0016020,GO:0031618,GO:0035064,GO:0051301,GO:0051304 condensed chromosome, centromeric region|nuclear condensin complex|chromatin binding|nucleoplasm|mitotic chromosome condensation|meiotic chromosome condensation|membrane|nuclear pericentric heterochromatin|methylated histone binding|cell division|chromosome separation NCAPG 1059.86608886147 1104.33881730945 1015.3933604135 0.919458181219555 -0.121144135387884 0.590332910211679 1 9.0054 7.80915 8.9323 6.88806 GeneID:64151,Genbank:NM_022346.4,HGNC:HGNC:24304,MIM:606280 non-SMC condensin I complex subunit G GO:0000779,GO:0000796,GO:0005634,GO:0005737,GO:0005829,GO:0007076,GO:0016020,GO:0051301 condensed chromosome, centromeric region|condensin complex|nucleus|cytoplasm|cytosol|mitotic chromosome condensation|membrane|cell division NCAPG2 4606.27247365369 4658.26950224782 4554.27544505956 0.977675388438114 -0.032572559390737 0.82358489413055 1 27.288 26.2872 27.9615 24.2995 GeneID:54892,Genbank:NM_017760.6,HGNC:HGNC:21904,MIM:608532 non-SMC condensin II complex subunit G2 GO:0000796,GO:0001833,GO:0005654,GO:0007049,GO:0016020,GO:0016607,GO:0030261,GO:0035064,GO:0051301 condensin complex|inner cell mass cell proliferation|nucleoplasm|cell cycle|membrane|nuclear speck|chromosome condensation|methylated histone binding|cell division NCAPH 1922.8304019311 1985.12696743892 1860.53383642328 0.93723669414638 -0.0935146560227519 0.509807924246084 1 9.91626 10.037 10.007 9.05133 GeneID:23397,Genbank:NM_015341.4,HGNC:HGNC:1112,MIM:602332 non-SMC condensin I complex subunit H GO:0000796,GO:0000799,GO:0003682,GO:0005634,GO:0005829,GO:0007076,GO:0010032,GO:0016020,GO:0044547,GO:0045132,GO:0051301,GO:0072587 condensin complex|nuclear condensin complex|chromatin binding|nucleus|cytosol|mitotic chromosome condensation|meiotic chromosome condensation|membrane|DNA topoisomerase binding|meiotic chromosome segregation|cell division|DNA topoisomerase (ATP-hydrolyzing) activator activity NCAPH2 1474.09751485214 1389.22317232498 1558.9718573793 1.12218964413775 0.166316504411415 0.29751117508977 1 7.50386 8.65395 9.3371 10.2151 GeneID:29781,Genbank:NM_001185011.1,HGNC:HGNC:25071,MIM:611230 non-SMC condensin II complex subunit H2 GO:0005634,GO:0005654,GO:0005694,GO:0016020,GO:0030054,GO:0030261,GO:0045171 nucleus|nucleoplasm|chromosome|membrane|cell junction|chromosome condensation|intercellular bridge NCBP1 943.385774884773 1005.11610539745 881.655444372092 0.87716776165223 -0.189075304945089 0.434599111323019 1 6.91158 5.94248 6.8191 4.73032 GeneID:4686,Genbank:NM_001351504.1,HGNC:HGNC:7658,MIM:600469 nuclear cap binding protein subunit 1 GO:0000184,GO:0000245,GO:0000339,GO:0000340,GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0005845,GO:0005846,GO:0006366,GO:0006368,GO:0006369,GO:0006370,GO:0006405,GO:0006406,GO:0006446,GO:0008334,GO:0008380,GO:0008543,GO:0016070,GO:0030307,GO:0030529,GO:0031053,GO:0031124,GO:0031442,GO:0034518,GO:0042795,GO:0045292,GO:0048026,GO:0051168,GO:0098789,GO:1905216 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|spliceosomal complex assembly|RNA cap binding|RNA 7-methylguanosine cap binding|mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|mitochondrion|cytosol|mRNA cap binding complex|nuclear cap binding complex|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|termination of RNA polymerase II transcription|7-methylguanosine mRNA capping|RNA export from nucleus|mRNA export from nucleus|regulation of translational initiation|histone mRNA metabolic process|RNA splicing|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of cell growth|intracellular ribonucleoprotein complex|primary miRNA processing|mRNA 3'-end processing|positive regulation of mRNA 3'-end processing|RNA cap binding complex|snRNA transcription from RNA polymerase II promoter|mRNA cis splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|nuclear export|pre-mRNA cleavage required for polyadenylation|positive regulation of RNA binding hsa03013,hsa03015,hsa03040 RNA transport|mRNA surveillance pathway|Spliceosome NCBP2 2319.40408594518 2541.29777837558 2097.51039351479 0.825369782070771 -0.276887474636279 0.0485927948889553 0.806708656465773 16.6748 16.3789 14.2522 13.2969 GeneID:22916,Genbank:XM_011512556.3,HGNC:HGNC:7659,MIM:605133 nuclear cap binding protein subunit 2 GO:0000184,GO:0000339,GO:0000340,GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005845,GO:0005846,GO:0006366,GO:0006368,GO:0006369,GO:0006370,GO:0006405,GO:0006406,GO:0006408,GO:0006446,GO:0008334,GO:0008380,GO:0008543,GO:0016070,GO:0017069,GO:0031047,GO:0031124,GO:0031442,GO:0034518,GO:0042795,GO:0045292,GO:0046833,GO:0051168,GO:0098789 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA cap binding|RNA 7-methylguanosine cap binding|mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA cap binding complex|nuclear cap binding complex|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|termination of RNA polymerase II transcription|7-methylguanosine mRNA capping|RNA export from nucleus|mRNA export from nucleus|snRNA export from nucleus|regulation of translational initiation|histone mRNA metabolic process|RNA splicing|fibroblast growth factor receptor signaling pathway|RNA metabolic process|snRNA binding|gene silencing by RNA|mRNA 3'-end processing|positive regulation of mRNA 3'-end processing|RNA cap binding complex|snRNA transcription from RNA polymerase II promoter|mRNA cis splicing, via spliceosome|positive regulation of RNA export from nucleus|nuclear export|pre-mRNA cleavage required for polyadenylation hsa03013,hsa03015,hsa03040 RNA transport|mRNA surveillance pathway|Spliceosome NCBP2-AS2 577.059983721802 560.977506408577 593.142461035027 1.05733733395546 0.0804357290219803 0.645003413391171 1 36.164 35.9502 37.0456 41.2481 GeneID:152217,Genbank:NM_001355243.1,HGNC:HGNC:25121 NCBP2 antisense RNA 2 (head to head) NCBP3 936.105323957424 955.266143569315 916.944504345533 0.959883808840336 -0.059068312548256 0.701403580626525 1 3.83649 4.04147 3.95345 3.50601 GeneID:55421,Genbank:NM_001114118.2,HGNC:HGNC:24612,MIM:616624 nuclear cap binding subunit 3 GO:0000340,GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0006370,GO:0016607,GO:0034518,GO:0051028,GO:0051607 RNA 7-methylguanosine cap binding|RNA binding|mRNA binding|nucleus|cytoplasm|7-methylguanosine mRNA capping|nuclear speck|RNA cap binding complex|mRNA transport|defense response to virus NCCRP1 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0410717 0 0 GeneID:342897,Genbank:NM_001001414.1,HGNC:HGNC:33739,MIM:615901 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) GO:0005737,GO:0008284,GO:0070062 cytoplasm|positive regulation of cell proliferation|extracellular exosome NCDN 1443.59468735314 1418.30885582814 1468.88051887815 1.03565631198184 0.0505453164767991 0.746638737530495 1 17.8329 18.0957 18.4483 19.2048 GeneID:23154,Genbank:NM_014284.2,HGNC:HGNC:17597,MIM:608458 neurochondrin GO:0005829,GO:0016020,GO:0030425,GO:0031175,GO:0043025,GO:0045453,GO:0048168 cytosol|membrane|dendrite|neuron projection development|neuronal cell body|bone resorption|regulation of neuronal synaptic plasticity NCEH1 3259.47238294399 3450.50026116347 3068.44450472452 0.889275256478282 -0.16929805075792 0.210948261640983 1 34.5721 36.9263 35.823 27.8404 GeneID:57552,Genbank:NM_001146278.1,HGNC:HGNC:29260,MIM:613234 neutral cholesterol ester hydrolase 1 GO:0004771,GO:0005789,GO:0006805,GO:0009056,GO:0016020,GO:0016021,GO:0016042,GO:0017171,GO:0034383 sterol esterase activity|endoplasmic reticulum membrane|xenobiotic metabolic process|catabolic process|membrane|integral component of membrane|lipid catabolic process|serine hydrolase activity|low-density lipoprotein particle clearance hsa04927,hsa04934,hsa04976,hsa04979 Cortisol synthesis and secretion|Cushing syndrome|Bile secretion|Cholesterol metabolism NCF2 10.5697367560953 15.3264836296251 5.81298988256547 0.379277466576177 -1.39867443331185 0.122219933635923 1 0.190606 0.20321 0.0418907 0.0649962 GeneID:4688,Genbank:NM_001127651.2,HGNC:HGNC:7661,MIM:608515 neutrophil cytosolic factor 2 hsa04145,hsa04380,hsa04670,hsa05140,hsa05418 Phagosome|Osteoclast differentiation|Leukocyte transendothelial migration|Leishmaniasis|Fluid shear stress and atherosclerosis NCK1 228.090951308344 248.749273436218 207.432629180469 0.833902452517743 -0.262049463615205 0.247352875822762 1 2.19953 1.81229 1.88309 1.51696 GeneID:4690,Genbank:NM_001291999.1,HGNC:HGNC:7664,MIM:600508 NCK adaptor protein 1 GO:0000164,GO:0004860,GO:0005070,GO:0005102,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005840,GO:0005886,GO:0005911,GO:0006930,GO:0007015,GO:0007172,GO:0008093,GO:0010976,GO:0012506,GO:0019904,GO:0030032,GO:0030159,GO:0030334,GO:0030674,GO:0030838,GO:0030971,GO:0033137,GO:0036493,GO:0038096,GO:0042102,GO:0042110,GO:0045296,GO:0045944,GO:0046875,GO:0048010,GO:0048013,GO:0050852,GO:0051707,GO:0060548,GO:0070262,GO:0071074,GO:1902237,GO:1903676,GO:1903679,GO:1903898,GO:1903912,GO:1990441 protein phosphatase type 1 complex|protein kinase inhibitor activity|SH3/SH2 adaptor activity|receptor binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|ribosome|plasma membrane|cell-cell junction|substrate-dependent cell migration, cell extension|actin filament organization|signal complex assembly|cytoskeletal adaptor activity|positive regulation of neuron projection development|vesicle membrane|protein domain specific binding|lamellipodium assembly|receptor signaling complex scaffold activity|regulation of cell migration|protein binding, bridging|positive regulation of actin filament polymerization|receptor tyrosine kinase binding|negative regulation of peptidyl-serine phosphorylation|positive regulation of translation in response to endoplasmic reticulum stress|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of T cell proliferation|T cell activation|cadherin binding|positive regulation of transcription from RNA polymerase II promoter|ephrin receptor binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|T cell receptor signaling pathway|response to other organism|negative regulation of cell death|peptidyl-serine dephosphorylation|eukaryotic initiation factor eIF2 binding|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of cap-dependent translational initiation|positive regulation of cap-independent translational initiation|negative regulation of PERK-mediated unfolded protein response|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress hsa04012,hsa04360,hsa04660,hsa05130 ErbB signaling pathway|Axon guidance|T cell receptor signaling pathway|Pathogenic Escherichia coli infection NCK2 303.267983863544 280.383400500238 326.15256722685 1.16323779027201 0.218146044171058 0.289947503550244 1 2.48383 2.96098 3.40303 3.29933 GeneID:8440,Genbank:XM_017005105.1,HGNC:HGNC:7665,MIM:604930 NCK adaptor protein 2 GO:0001771,GO:0001784,GO:0005070,GO:0005737,GO:0005783,GO:0005829,GO:0007015,GO:0007165,GO:0007172,GO:0007173,GO:0007176,GO:0008093,GO:0008285,GO:0012506,GO:0014069,GO:0016477,GO:0030032,GO:0030159,GO:0030838,GO:0032403,GO:0033137,GO:0036493,GO:0042102,GO:0042110,GO:0045944,GO:0048010,GO:0048013,GO:0060996,GO:0097110,GO:1902237,GO:1903898,GO:1903912,GO:1990441 immunological synapse formation|phosphotyrosine residue binding|SH3/SH2 adaptor activity|cytoplasm|endoplasmic reticulum|cytosol|actin filament organization|signal transduction|signal complex assembly|epidermal growth factor receptor signaling pathway|regulation of epidermal growth factor-activated receptor activity|cytoskeletal adaptor activity|negative regulation of cell proliferation|vesicle membrane|postsynaptic density|cell migration|lamellipodium assembly|receptor signaling complex scaffold activity|positive regulation of actin filament polymerization|protein complex binding|negative regulation of peptidyl-serine phosphorylation|positive regulation of translation in response to endoplasmic reticulum stress|positive regulation of T cell proliferation|T cell activation|positive regulation of transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|dendritic spine development|scaffold protein binding|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of PERK-mediated unfolded protein response|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress hsa04012,hsa04360,hsa04660,hsa05130 ErbB signaling pathway|Axon guidance|T cell receptor signaling pathway|Pathogenic Escherichia coli infection NCKAP1 1741.36008830278 1824.05615532836 1658.6640212772 0.909327279443663 -0.137128461138043 0.655298659225972 1 14.8772 12.356 14.7703 9.98999 GeneID:10787,Genbank:NM_013436.4,HGNC:HGNC:7666,MIM:604891 NCK associated protein 1 GO:0001726,GO:0005829,GO:0005925,GO:0006915,GO:0007417,GO:0010592,GO:0016021,GO:0016032,GO:0016601,GO:0030027,GO:0030838,GO:0031209,GO:0031258,GO:0031941,GO:0032403,GO:0038096,GO:0048010,GO:0070062,GO:2000601 ruffle|cytosol|focal adhesion|apoptotic process|central nervous system development|positive regulation of lamellipodium assembly|integral component of membrane|viral process|Rac protein signal transduction|lamellipodium|positive regulation of actin filament polymerization|SCAR complex|lamellipodium membrane|filamentous actin|protein complex binding|Fc-gamma receptor signaling pathway involved in phagocytosis|vascular endothelial growth factor receptor signaling pathway|extracellular exosome|positive regulation of Arp2/3 complex-mediated actin nucleation hsa04810 Regulation of actin cytoskeleton NCKAP1L 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0189505 0 GeneID:3071,Genbank:NM_005337.4,HGNC:HGNC:4862,MIM:141180 NCK associated protein 1 like GO:0001782,GO:0002262,GO:0005096,GO:0005829,GO:0005886,GO:0005887,GO:0006461,GO:0006935,GO:0016020,GO:0030011,GO:0030295,GO:0030593,GO:0030667,GO:0030838,GO:0030866,GO:0030890,GO:0031209,GO:0032403,GO:0032700,GO:0032715,GO:0033630,GO:0034101,GO:0035509,GO:0038096,GO:0042102,GO:0042327,GO:0042493,GO:0043029,GO:0043066,GO:0043312,GO:0043372,GO:0043378,GO:0045579,GO:0045588,GO:0045621,GO:0045648,GO:0048010,GO:0048821,GO:0050853,GO:0060100,GO:0070062,GO:0070358,GO:0090023,GO:0101003 B cell homeostasis|myeloid cell homeostasis|GTPase activator activity|cytosol|plasma membrane|integral component of plasma membrane|protein complex assembly|chemotaxis|membrane|maintenance of cell polarity|protein kinase activator activity|neutrophil chemotaxis|secretory granule membrane|positive regulation of actin filament polymerization|cortical actin cytoskeleton organization|positive regulation of B cell proliferation|SCAR complex|protein complex binding|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|positive regulation of cell adhesion mediated by integrin|erythrocyte homeostasis|negative regulation of myosin-light-chain-phosphatase activity|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of T cell proliferation|positive regulation of phosphorylation|response to drug|T cell homeostasis|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of B cell differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of lymphocyte differentiation|positive regulation of erythrocyte differentiation|vascular endothelial growth factor receptor signaling pathway|erythrocyte development|B cell receptor signaling pathway|positive regulation of phagocytosis, engulfment|extracellular exosome|actin polymerization-dependent cell motility|positive regulation of neutrophil chemotaxis|ficolin-1-rich granule membrane hsa04810 Regulation of actin cytoskeleton NCKAP5 1.99199762632372 1.07619535328461 2.90779989936283 2.70192571496249 1.43398801066343 0.610245231378652 1 0.00453072 0 0.0064999 0.00404126 GeneID:344148,Genbank:XM_017003975.2,HGNC:HGNC:29847,MIM:608789 NCK associated protein 5 NCKAP5L 566.79504300428 554.453707704824 579.136378303737 1.04451709900379 0.0628361098737169 0.746159671584318 1 3.12625 3.64894 3.93674 3.54812 GeneID:57701,Genbank:XM_006719525.2,HGNC:HGNC:29321,MIM:615104 NCK associated protein 5 like GO:0001578,GO:0005737,GO:0005813,GO:0007019,GO:0035371 microtubule bundle formation|cytoplasm|centrosome|microtubule depolymerization|microtubule plus-end NCKIPSD 1342.65060721567 1277.02726424293 1408.2739501884 1.102775163554 0.141138680784123 0.353719529257166 1 9.72714 10.84 11.768 11.8556 GeneID:51517,Genbank:XM_017006595.1,HGNC:HGNC:15486,MIM:606671 NCK interacting protein with SH3 domain NCL 10368.2839220804 11921.7682518372 8814.79959232358 0.739386927016066 -0.435598559200755 0.0010160648642616 0.103795225877033 109.335 97.1186 82.9035 71.8769 GeneID:4691,Genbank:NM_005381.2,HGNC:HGNC:7667,MIM:164035 nucleolin GO:0001525,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005938,GO:0008022,GO:0016020,GO:0017148,GO:0030529,GO:0036464,GO:0042162,GO:0042802,GO:0044547,GO:0045944,GO:0048027,GO:0070062,GO:0071364,GO:1901838,GO:1990830 angiogenesis|RNA binding|nucleus|nucleoplasm|nucleolus|cell cortex|protein C-terminus binding|membrane|negative regulation of translation|intracellular ribonucleoprotein complex|cytoplasmic ribonucleoprotein granule|telomeric DNA binding|identical protein binding|DNA topoisomerase binding|positive regulation of transcription from RNA polymerase II promoter|mRNA 5'-UTR binding|extracellular exosome|cellular response to epidermal growth factor stimulus|positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|cellular response to leukemia inhibitory factor hsa05130 Pathogenic Escherichia coli infection NCLN 3851.87991876155 3721.64401661484 3982.11582090827 1.06998837157197 0.0975951177791178 0.491343115189888 1 46.4997 49.5907 52.2498 52.1307 GeneID:56926,Genbank:NM_020170.3,HGNC:HGNC:26923,MIM:609156 nicalin GO:0005789,GO:0009966,GO:0016020,GO:0016021,GO:0031648,GO:0043254 endoplasmic reticulum membrane|regulation of signal transduction|membrane|integral component of membrane|protein destabilization|regulation of protein complex assembly NCMAP 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00546561 GeneID:400746,Genbank:NM_001010980.4,HGNC:HGNC:29332 non-compact myelin associated protein GO:0005887,GO:0019911,GO:0031643,GO:0032290,GO:0033270,GO:0043220 integral component of plasma membrane|structural constituent of myelin sheath|positive regulation of myelination|peripheral nervous system myelin formation|paranode region of axon|Schmidt-Lanterman incisure NCOA1 521.166038345699 506.695250650896 535.636826040503 1.05711830800156 0.0801368457989203 0.825641178036513 1 2.19548 2.13567 2.94397 1.68692 GeneID:8648,Genbank:XM_017005168.1,HGNC:HGNC:7668,MIM:602691 nuclear receptor coactivator 1 hsa04915,hsa04919,hsa05200,hsa05224 Estrogen signaling pathway|Thyroid hormone signaling pathway|Pathways in cancer|Breast cancer NCOA2 294.482732820637 277.759538701073 311.205926940201 1.12041490418489 0.164033079930458 0.679841284160362 1 0.584092 0.558373 0.860581 0.463029 GeneID:10499,Genbank:NM_001321703.1,HGNC:HGNC:7669,MIM:601993 nuclear receptor coactivator 2 GO:0000122,GO:0000978,GO:0001162,GO:0003682,GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006355,GO:0010906,GO:0015721,GO:0016604,GO:0016922,GO:0017162,GO:0019216,GO:0019904,GO:0030374,GO:0030375,GO:0030522,GO:0032870,GO:0032922,GO:0035257,GO:0043234,GO:0045475,GO:0045944,GO:0046983,GO:1904017 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|chromatin binding|transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of glucose metabolic process|bile acid and bile salt transport|nuclear body|ligand-dependent nuclear receptor binding|aryl hydrocarbon receptor binding|regulation of lipid metabolic process|protein domain specific binding|ligand-dependent nuclear receptor transcription coactivator activity|thyroid hormone receptor coactivator activity|intracellular receptor signaling pathway|cellular response to hormone stimulus|circadian regulation of gene expression|nuclear hormone receptor binding|protein complex|locomotor rhythm|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|cellular response to Thyroglobulin triiodothyronine hsa04915,hsa04919 Estrogen signaling pathway|Thyroid hormone signaling pathway NCOA3 427.596510477159 401.524038330512 453.668982623805 1.12986755291191 0.176153664714527 0.394440926411893 1 1.83445 1.70466 2.35676 1.61607 GeneID:8202,Genbank:NM_001174088.1,HGNC:HGNC:7670,MIM:601937 nuclear receptor coactivator 3 hsa01522,hsa04915,hsa04919,hsa05200,hsa05224 Endocrine resistance|Estrogen signaling pathway|Thyroid hormone signaling pathway|Pathways in cancer|Breast cancer NCOA4 2823.07236700017 2969.94823160227 2676.19650239807 0.901091969860458 -0.150253732810646 0.282162690902035 1 24.6213 23.2813 22.9979 20.9234 GeneID:8031,Genbank:NM_001145263.1,HGNC:HGNC:7671,MIM:601984 nuclear receptor coactivator 4 hsa04216,hsa05200,hsa05216 Ferroptosis|Pathways in cancer|Thyroid cancer NCOA5 1514.48526821731 1533.867620139 1495.10291629562 0.974727477564284 -0.0369291803572555 0.782409698813453 1 16.2477 17.3486 17.2601 15.8432 GeneID:57727,Genbank:NM_001348148.1,HGNC:HGNC:15909,MIM:616825 nuclear receptor coactivator 5 GO:0003682,GO:0003723,GO:0005615,GO:0005634,GO:0006351,GO:0006355,GO:0015629,GO:0042593,GO:0046627 chromatin binding|RNA binding|extracellular space|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|actin cytoskeleton|glucose homeostasis|negative regulation of insulin receptor signaling pathway NCOA6 1557.64729532107 1593.94143782334 1521.35315281879 0.954459879590262 -0.0672435391991301 0.649763083110217 1 5.32474 5.20158 5.49128 4.61169 GeneID:23054,Genbank:NM_014071.4,HGNC:HGNC:15936,MIM:605299 nuclear receptor coactivator 6 GO:0003682,GO:0003713,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006260,GO:0006281,GO:0006310,GO:0006352,GO:0006974,GO:0007420,GO:0007507,GO:0009725,GO:0019216,GO:0019899,GO:0030099,GO:0030331,GO:0030374,GO:0030520,GO:0035097,GO:0042921,GO:0043231,GO:0045893,GO:0045944,GO:0046965,GO:0046966 chromatin binding|transcription coactivator activity|nucleus|nucleoplasm|transcription factor complex|cytosol|DNA replication|DNA repair|DNA recombination|DNA-templated transcription, initiation|cellular response to DNA damage stimulus|brain development|heart development|response to hormone|regulation of lipid metabolic process|enzyme binding|myeloid cell differentiation|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|intracellular estrogen receptor signaling pathway|histone methyltransferase complex|glucocorticoid receptor signaling pathway|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|retinoid X receptor binding|thyroid hormone receptor binding NCOA7 535.094255657939 519.061688558561 551.126822757317 1.06177518954982 0.086478335581978 0.777690849195718 1 2.3018 2.14638 2.92178 1.85512 GeneID:135112,Genbank:XM_017010274.2,HGNC:HGNC:21081,MIM:609752 nuclear receptor coactivator 7 GO:0005622,GO:0005634,GO:0006351,GO:0030374,GO:0035257,GO:0045944,GO:1902083,GO:1903204 intracellular|nucleus|transcription, DNA-templated|ligand-dependent nuclear receptor transcription coactivator activity|nuclear hormone receptor binding|positive regulation of transcription from RNA polymerase II promoter|negative regulation of peptidyl-cysteine S-nitrosylation|negative regulation of oxidative stress-induced neuron death NCOR1 2421.62865354432 2425.63315286024 2417.6241542284 0.996698182236501 -0.00477139759797831 0.99604616345304 1 6.24431 5.70384 6.9995 5.02105 GeneID:9611,Genbank:NM_006311.3,HGNC:HGNC:7672,MIM:600849 nuclear receptor corepressor 1 GO:0000122,GO:0000790,GO:0001102,GO:0003714,GO:0005634,GO:0005654,GO:0005829,GO:0005876,GO:0006366,GO:0007623,GO:0016020,GO:0016569,GO:0016922,GO:0017053,GO:0019216,GO:0035257,GO:0042826,GO:0044212,GO:0046329,GO:0046966,GO:0051225,GO:0072362,GO:0072368,GO:1903799,GO:2000191 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II activating transcription factor binding|transcription corepressor activity|nucleus|nucleoplasm|cytosol|spindle microtubule|transcription from RNA polymerase II promoter|circadian rhythm|membrane|covalent chromatin modification|ligand-dependent nuclear receptor binding|transcriptional repressor complex|regulation of lipid metabolic process|nuclear hormone receptor binding|histone deacetylase binding|transcription regulatory region DNA binding|negative regulation of JNK cascade|thyroid hormone receptor binding|spindle assembly|regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of production of miRNAs involved in gene silencing by miRNA|regulation of fatty acid transport hsa01522,hsa04919,hsa05202 Endocrine resistance|Thyroid hormone signaling pathway|Transcriptional misregulation in cancer NCOR2 5626.27408711099 5639.51553212601 5613.03264209597 0.995304048746886 -0.00679078268591464 0.946743911324434 1 19.3838 18.893 20.1371 19.0352 GeneID:9612,Genbank:NM_001077261.3,HGNC:HGNC:7673,MIM:600848 nuclear receptor corepressor 2 GO:0000118,GO:0000122,GO:0000790,GO:0003677,GO:0003714,GO:0005112,GO:0005634,GO:0005654,GO:0006351,GO:0008134,GO:0016020,GO:0016363,GO:0016604,GO:0016922,GO:0017053,GO:0019216,GO:0042826,GO:0047485,GO:0072365,GO:1903799 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|DNA binding|transcription corepressor activity|Notch binding|nucleus|nucleoplasm|transcription, DNA-templated|transcription factor binding|membrane|nuclear matrix|nuclear body|ligand-dependent nuclear receptor binding|transcriptional repressor complex|regulation of lipid metabolic process|histone deacetylase binding|protein N-terminus binding|regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter|negative regulation of production of miRNAs involved in gene silencing by miRNA hsa04330,hsa05169 Notch signaling pathway|Epstein-Barr virus infection NCR3 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0975607 GeneID:259197,Genbank:NM_147130.2,HGNC:HGNC:19077,MIM:611550 natural cytotoxicity triggering receptor 3 GO:0002429,GO:0002860,GO:0004872,GO:0005102,GO:0005886,GO:0005887,GO:0005913,GO:0006954,GO:0006955,GO:0007156,GO:0007157,GO:0008037,GO:0030101,GO:0042271,GO:0042802,GO:0042803,GO:0045954,GO:0050776,GO:0050839,GO:0060370 immune response-activating cell surface receptor signaling pathway|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|receptor activity|receptor binding|plasma membrane|integral component of plasma membrane|cell-cell adherens junction|inflammatory response|immune response|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell recognition|natural killer cell activation|susceptibility to natural killer cell mediated cytotoxicity|identical protein binding|protein homodimerization activity|positive regulation of natural killer cell mediated cytotoxicity|regulation of immune response|cell adhesion molecule binding|susceptibility to T cell mediated cytotoxicity hsa04650 Natural killer cell mediated cytotoxicity NCR3LG1 380.756153562432 389.263461627325 372.248845497539 0.956290230635427 -0.06447955748377 0.767530579667447 1 1.52473 1.65558 1.82778 1.29708 GeneID:374383,Genbank:NM_001202439.2,HGNC:HGNC:42400,MIM:613714 natural killer cell cytotoxicity receptor 3 ligand 1 GO:0005198,GO:0005886,GO:0016021,GO:0019028,GO:0050776 structural molecule activity|plasma membrane|integral component of membrane|viral capsid|regulation of immune response NCS1 2274.13295079818 2279.32841974333 2268.93748185303 0.99544122830203 -0.00659195437120111 0.959454111757058 1 20.8771 20.8058 20.7904 21.2864 GeneID:23413,Genbank:NM_014286.3,HGNC:HGNC:3953,MIM:603315 neuronal calcium sensor 1 GO:0000287,GO:0005245,GO:0005509,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0010975,GO:0014069,GO:0019901,GO:0030054,GO:0030424,GO:0030425,GO:0031045,GO:0043231,GO:0045211,GO:0045921,GO:0048015,GO:0048471,GO:0050806 magnesium ion binding|voltage-gated calcium channel activity|calcium ion binding|cytoplasm|Golgi apparatus|cytosol|plasma membrane|regulation of neuron projection development|postsynaptic density|protein kinase binding|cell junction|axon|dendrite|dense core granule|intracellular membrane-bounded organelle|postsynaptic membrane|positive regulation of exocytosis|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|positive regulation of synaptic transmission NCSTN 3291.79347220641 2805.84805753658 3777.73888687624 1.34638042025445 0.429086101531537 0.00162769667915479 0.142454590236847 24.4662 25.419 35.8131 33.0894 GeneID:23385,Genbank:NM_001290184.1,HGNC:HGNC:17091,MIM:605254 nicastrin GO:0002262,GO:0004175,GO:0005765,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005925,GO:0006508,GO:0006509,GO:0007219,GO:0007220,GO:0016020,GO:0016021,GO:0016485,GO:0031293,GO:0034205,GO:0035333,GO:0035577,GO:0042098,GO:0042470,GO:0042982,GO:0042987,GO:0043065,GO:0043085,GO:0043312,GO:0048013,GO:0050673,GO:0070062,GO:0070765 myeloid cell homeostasis|endopeptidase activity|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|focal adhesion|proteolysis|membrane protein ectodomain proteolysis|Notch signaling pathway|Notch receptor processing|membrane|integral component of membrane|protein processing|membrane protein intracellular domain proteolysis|amyloid-beta formation|Notch receptor processing, ligand-dependent|azurophil granule membrane|T cell proliferation|melanosome|amyloid precursor protein metabolic process|amyloid precursor protein catabolic process|positive regulation of apoptotic process|positive regulation of catalytic activity|neutrophil degranulation|ephrin receptor signaling pathway|epithelial cell proliferation|extracellular exosome|gamma-secretase complex hsa04330,hsa05010 Notch signaling pathway|Alzheimer disease NDC1 1701.1609927784 1955.63542242636 1446.68656313045 0.739752689351242 -0.434885058579152 0.00249773100856325 0.182315270901352 16.9048 15.9606 13.3648 11.2688 GeneID:55706,Genbank:NM_001168551.1,HGNC:HGNC:25525,MIM:610115 NDC1 transmembrane nucleoporin GO:0005635,GO:0005643,GO:0005737,GO:0005886,GO:0006110,GO:0006406,GO:0006409,GO:0007077,GO:0007129,GO:0007283,GO:0015031,GO:0015629,GO:0016020,GO:0016021,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031081,GO:0031965,GO:0043657,GO:0051292,GO:0060964,GO:0070762,GO:0075733,GO:1900034 nuclear envelope|nuclear pore|cytoplasm|plasma membrane|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|mitotic nuclear envelope disassembly|synapsis|spermatogenesis|protein transport|actin cytoskeleton|membrane|integral component of membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear pore distribution|nuclear membrane|host cell|nuclear pore complex assembly|regulation of gene silencing by miRNA|nuclear pore transmembrane ring|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NDC80 886.079604458353 935.191816398424 836.967392518281 0.894968687537899 -0.1600908875094 0.314636371774733 1 13.7809 13.3357 12.6275 11.5761 GeneID:10403,Genbank:NM_006101.2,HGNC:HGNC:16909,MIM:607272 NDC80, kinetochore complex component GO:0000070,GO:0000132,GO:0000278,GO:0000775,GO:0000776,GO:0000777,GO:0000942,GO:0005200,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0007052,GO:0007059,GO:0007062,GO:0008608,GO:0016020,GO:0031262,GO:0042802,GO:0051301,GO:0051310,GO:0051315,GO:0051383,GO:0090267,GO:1905342 mitotic sister chromatid segregation|establishment of mitotic spindle orientation|mitotic cell cycle|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome outer kinetochore|structural constituent of cytoskeleton|nucleus|nucleoplasm|centrosome|cytosol|mitotic spindle organization|chromosome segregation|sister chromatid cohesion|attachment of spindle microtubules to kinetochore|membrane|Ndc80 complex|identical protein binding|cell division|metaphase plate congression|attachment of mitotic spindle microtubules to kinetochore|kinetochore organization|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of protein localization to kinetochore NDE1 1509.60839388265 1491.67345329598 1527.54333446932 1.02404673830864 0.0342815625911403 0.822996670600144 1 6.18075 6.34783 6.49908 6.47701 GeneID:54820,Genbank:NM_001143979.1,HGNC:HGNC:17619,MIM:609449 nudE neurodevelopment protein 1 GO:0000086,GO:0000132,GO:0000776,GO:0000777,GO:0001764,GO:0005813,GO:0005829,GO:0005871,GO:0005874,GO:0007020,GO:0007059,GO:0007062,GO:0007100,GO:0007405,GO:0008017,GO:0010389,GO:0016020,GO:0016477,GO:0019904,GO:0021987,GO:0031616,GO:0032154,GO:0042802,GO:0045202,GO:0047496,GO:0051298,GO:0051301,GO:0051303,GO:0051642,GO:0097711,GO:2000574 G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|kinetochore|condensed chromosome kinetochore|neuron migration|centrosome|cytosol|kinesin complex|microtubule|microtubule nucleation|chromosome segregation|sister chromatid cohesion|mitotic centrosome separation|neuroblast proliferation|microtubule binding|regulation of G2/M transition of mitotic cell cycle|membrane|cell migration|protein domain specific binding|cerebral cortex development|spindle pole centrosome|cleavage furrow|identical protein binding|synapse|vesicle transport along microtubule|centrosome duplication|cell division|establishment of chromosome localization|centrosome localization|ciliary basal body-plasma membrane docking|regulation of microtubule motor activity NDEL1 983.638409270474 983.420727544093 983.856090996854 1.00044270314888 0.000638544305119221 1 1 8.05113 8.26342 8.70088 7.35296 GeneID:81565,Genbank:NM_001025579.2,HGNC:HGNC:17620,MIM:607538 nudE neurodevelopment protein 1 like 1 GO:0000777,GO:0005737,GO:0005815,GO:0005819,GO:0005874,GO:0007100,GO:0007399,GO:0030154,GO:0032418,GO:0060052,GO:1900029,GO:2000574 condensed chromosome kinetochore|cytoplasm|microtubule organizing center|spindle|microtubule|mitotic centrosome separation|nervous system development|cell differentiation|lysosome localization|neurofilament cytoskeleton organization|positive regulation of ruffle assembly|regulation of microtubule motor activity NDFIP1 3513.55775884513 3327.88635812476 3699.22915956549 1.1115851809465 0.152618506547923 0.251940539720448 1 48.4542 48.4117 56.372 51.9032 GeneID:80762,Genbank:NM_030571.3,HGNC:HGNC:17592,MIM:612050 Nedd4 family interacting protein 1 GO:0000139,GO:0002761,GO:0002829,GO:0004871,GO:0005576,GO:0005794,GO:0005938,GO:0006879,GO:0007034,GO:0010008,GO:0010629,GO:0016021,GO:0030001,GO:0030054,GO:0030425,GO:0031398,GO:0032410,GO:0032713,GO:0042130,GO:0043123,GO:0045202,GO:0045619,GO:0045732,GO:0048294,GO:0048302,GO:0048471,GO:0050699,GO:0050728,GO:0051224 Golgi membrane|regulation of myeloid leukocyte differentiation|negative regulation of type 2 immune response|signal transducer activity|extracellular region|Golgi apparatus|cell cortex|cellular iron ion homeostasis|vacuolar transport|endosome membrane|negative regulation of gene expression|integral component of membrane|metal ion transport|cell junction|dendrite|positive regulation of protein ubiquitination|negative regulation of transporter activity|negative regulation of interleukin-4 production|negative regulation of T cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB signaling|synapse|regulation of lymphocyte differentiation|positive regulation of protein catabolic process|negative regulation of isotype switching to IgE isotypes|regulation of isotype switching to IgG isotypes|perinuclear region of cytoplasm|WW domain binding|negative regulation of inflammatory response|negative regulation of protein transport NDFIP2 839.429512121062 967.881504504658 710.977519737466 0.734570829619614 -0.445026488225233 0.00505517060288772 0.283089553761712 10.4325 9.71413 7.96666 6.73951 GeneID:54602,Genbank:XM_006719840.3,HGNC:HGNC:18537,MIM:610041 Nedd4 family interacting protein 2 GO:0000139,GO:0004871,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0007034,GO:0010629,GO:0016021,GO:0030001,GO:0031398,GO:0032410,GO:0032585,GO:0043123,GO:0043231,GO:0048471,GO:0050699,GO:0051224 Golgi membrane|signal transducer activity|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|vacuolar transport|negative regulation of gene expression|integral component of membrane|metal ion transport|positive regulation of protein ubiquitination|negative regulation of transporter activity|multivesicular body membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|WW domain binding|negative regulation of protein transport NDNF 54.7560844129777 60.085660341161 49.4265084847943 0.822600737083607 -0.281735730335247 0.46089165387538 1 0.175189 0.270292 0.1696 0.200577 GeneID:79625,Genbank:XM_024454213.1,HGNC:HGNC:26256,MIM:616506 neuron derived neurotrophic factor GO:0001525,GO:0001764,GO:0002931,GO:0005539,GO:0005576,GO:0005578,GO:0005622,GO:0007263,GO:0008201,GO:0010811,GO:0010976,GO:0019800,GO:0030198,GO:0031012,GO:0043524,GO:0061042,GO:0071456,GO:2000352 angiogenesis|neuron migration|response to ischemia|glycosaminoglycan binding|extracellular region|proteinaceous extracellular matrix|intracellular|nitric oxide mediated signal transduction|heparin binding|positive regulation of cell-substrate adhesion|positive regulation of neuron projection development|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix organization|extracellular matrix|negative regulation of neuron apoptotic process|vascular wound healing|cellular response to hypoxia|negative regulation of endothelial cell apoptotic process NDOR1 888.884166345047 806.60405498942 971.164277700675 1.20401611136633 0.267854697440464 0.0846395016627661 0.964561165794104 5.53239 4.90774 6.30584 6.68408 GeneID:27158,Genbank:NM_001144026.2,HGNC:HGNC:29838,MIM:606073 NADPH dependent diflavin oxidoreductase 1 GO:0003958,GO:0005634,GO:0005737,GO:0005829,GO:0008219,GO:0010181,GO:0016491,GO:0036245,GO:0045111,GO:0048471,GO:0050660,GO:0050661,GO:0055114 NADPH-hemoprotein reductase activity|nucleus|cytoplasm|cytosol|cell death|FMN binding|oxidoreductase activity|cellular response to menadione|intermediate filament cytoskeleton|perinuclear region of cytoplasm|flavin adenine dinucleotide binding|NADP binding|oxidation-reduction process NDP 556.028045918328 527.114553398834 584.941538437822 1.10970477795788 0.150175917993731 0.372253409262381 1 12.4002 12.015 13.8603 13.0306 GeneID:4693,Genbank:NM_000266.3,HGNC:HGNC:7678,MIM:300658 NDP, norrin cystine knot growth factor NDRG1 1002.99517632315 832.93364052617 1173.05671212014 1.40834354028384 0.493999296624096 0.208953544869425 1 5.85244 6.20792 7.05571 10.2664 GeneID:10397,Genbank:NM_001258432.1,HGNC:HGNC:7679,MIM:605262 N-myc downstream regulated 1 NDRG2 148.246909762432 138.514667962845 157.97915156202 1.14052290551926 0.189695421088634 0.461338209611963 1 1.11929 0.880822 1.06052 1.33601 GeneID:57447,Genbank:NM_001282211.1,HGNC:HGNC:14460,MIM:605272 NDRG family member 2 GO:0005737,GO:0007165,GO:0007420,GO:0016055,GO:0030154,GO:0030426,GO:0048471 cytoplasm|signal transduction|brain development|Wnt signaling pathway|cell differentiation|growth cone|perinuclear region of cytoplasm NDRG3 1737.67775106635 1593.50040969692 1881.85509243578 1.18095676724282 0.239956151165181 0.0932571956586838 0.989143871304291 13.0561 14.0976 17.1828 15.2315 GeneID:57446,Genbank:NM_022477.3,HGNC:HGNC:14462,MIM:605273 NDRG family member 3 GO:0005737,GO:0007165,GO:0007283,GO:0030154,GO:0030308,GO:0070062 cytoplasm|signal transduction|spermatogenesis|cell differentiation|negative regulation of cell growth|extracellular exosome NDRG4 784.569852533152 629.394380583013 939.74532448329 1.49309455799843 0.578305534551905 0.000308493351893366 0.0465903515773397 4.07418 4.39939 7.07524 5.79653 GeneID:65009,Genbank:NM_020465.3,HGNC:HGNC:14466,MIM:614463 NDRG family member 4 GO:0005829 cytosol NDST1 4350.91438823653 4393.81665399049 4308.01212248257 0.980471526632777 -0.0284523604231784 0.810348793273363 1 9.54718 10.5398 10.6033 9.41049 GeneID:3340,Genbank:XM_005268435.4,HGNC:HGNC:7680,MIM:600853 N-deacetylase and N-sulfotransferase 1 GO:0000139,GO:0003279,GO:0006024,GO:0006477,GO:0006954,GO:0007585,GO:0008543,GO:0015012,GO:0015014,GO:0015016,GO:0016021,GO:0030210,GO:0030900,GO:0030901,GO:0035904,GO:0042328,GO:0043410,GO:0045880,GO:0048702,GO:0048703,GO:0050119,GO:0060976 Golgi membrane|cardiac septum development|glycosaminoglycan biosynthetic process|protein sulfation|inflammatory response|respiratory gaseous exchange|fibroblast growth factor receptor signaling pathway|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|[heparan sulfate]-glucosamine N-sulfotransferase activity|integral component of membrane|heparin biosynthetic process|forebrain development|midbrain development|aorta development|heparan sulfate N-acetylglucosaminyltransferase activity|positive regulation of MAPK cascade|positive regulation of smoothened signaling pathway|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|N-acetylglucosamine deacetylase activity|coronary vasculature development hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin NDST2 561.570950645912 551.301556884124 571.840344407701 1.03725508710634 0.0527707327700241 0.780566215160339 1 3.57884 3.94387 3.8305 4.00071 GeneID:8509,Genbank:NM_001330107.1,HGNC:HGNC:7681,MIM:603268 N-deacetylase and N-sulfotransferase 2 GO:0000139,GO:0006024,GO:0015012,GO:0015016,GO:0016021,GO:0030210,GO:0050119 Golgi membrane|glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process|[heparan sulfate]-glucosamine N-sulfotransferase activity|integral component of membrane|heparin biosynthetic process|N-acetylglucosamine deacetylase activity hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin NDST3 30.2787191552903 30.9891511820448 29.5682871285358 0.954149629811989 -0.0677125673772752 0.945231791676873 1 0.0742594 0.0543592 0.0959495 0.0446228 GeneID:9348,Genbank:XM_006714416.3,HGNC:HGNC:7682,MIM:603950 N-deacetylase and N-sulfotransferase 3 GO:0000139,GO:0015012,GO:0015014,GO:0015016,GO:0016021,GO:0016787,GO:0030210,GO:0042328 Golgi membrane|heparan sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|[heparan sulfate]-glucosamine N-sulfotransferase activity|integral component of membrane|hydrolase activity|heparin biosynthetic process|heparan sulfate N-acetylglucosaminyltransferase activity hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin NDST4 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.00566873 0.00563962 0 GeneID:64579,Genbank:XM_017008545.2,HGNC:HGNC:20779,MIM:615039 N-deacetylase and N-sulfotransferase 4 GO:0000139,GO:0015012,GO:0015016,GO:0016021,GO:0019213,GO:0030210 Golgi membrane|heparan sulfate proteoglycan biosynthetic process|[heparan sulfate]-glucosamine N-sulfotransferase activity|integral component of membrane|deacetylase activity|heparin biosynthetic process hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin NDUFA1 4439.34489141465 4519.21506396007 4359.47471886922 0.96465307739728 -0.0519179022547432 0.848881376698784 1 529.724 584.859 454.733 613.363 GeneID:4694,Genbank:NM_004541.3,HGNC:HGNC:7683,MIM:300078 NADH:ubiquinone oxidoreductase subunit A1 GO:0005739,GO:0005743,GO:0005747,GO:0005829,GO:0006120,GO:0008137,GO:0016021,GO:0031966,GO:0032981 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|cytosol|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial membrane|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA10 1869.60430189331 1781.37700208766 1957.83160169896 1.09905516878489 0.136263806427924 0.339154411653885 1 7.0515 7.57515 8.17241 8.23551 GeneID:4705,Genbank:NM_001322020.1,HGNC:HGNC:7684,MIM:603835 NADH:ubiquinone oxidoreductase subunit A10 GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0006120,GO:0008137,GO:0032981,GO:0043209 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly|myelin sheath hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA11 3422.73438002647 3486.04144413806 3359.42731591488 0.963679683603279 -0.0533744045214838 0.839595506133787 1 42.3204 49.6239 37.2214 50.4426 GeneID:126328,Genbank:NM_001193375.1,HGNC:HGNC:20371,MIM:612638 NADH:ubiquinone oxidoreductase subunit A11 GO:0005747,GO:0016021,GO:0032981,GO:0055114 mitochondrial respiratory chain complex I|integral component of membrane|mitochondrial respiratory chain complex I assembly|oxidation-reduction process hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA12 925.921713634537 938.843847276189 912.999579992884 0.972472240875535 -0.0402710257888222 0.802913173222771 1 61.617 59.8748 57.1176 59.8545 GeneID:55967,Genbank:NM_001258338.1,HGNC:HGNC:23987,MIM:614530 NADH:ubiquinone oxidoreductase subunit A12 GO:0005739,GO:0005743,GO:0005747,GO:0005829,GO:0006120,GO:0006979,GO:0007585,GO:0008137,GO:0009055,GO:0032981,GO:0042775 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|cytosol|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|respiratory gaseous exchange|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA13 4853.03161572066 4863.73017453182 4842.33305690949 0.995600677493507 -0.00636088283258543 0.962173633387105 1 371.272 411.985 349.9 434.442 GeneID:51079,Genbank:NM_015965.6,HGNC:HGNC:17194,MIM:609435 NADH:ubiquinone oxidoreductase subunit A13 GO:0003954,GO:0005654,GO:0005737,GO:0005739,GO:0005746,GO:0005747,GO:0008137,GO:0016021,GO:0030308,GO:0031966,GO:0032981,GO:0035458,GO:0043280,GO:0045039,GO:0045732,GO:0045892,GO:0071300,GO:0072593,GO:0097190,GO:0097191,GO:2001243 NADH dehydrogenase activity|nucleoplasm|cytoplasm|mitochondrion|mitochondrial respiratory chain|mitochondrial respiratory chain complex I|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|negative regulation of cell growth|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|cellular response to interferon-beta|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein import into mitochondrial inner membrane|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|cellular response to retinoic acid|reactive oxygen species metabolic process|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA2 1789.60098212624 1851.17007192031 1728.03189233218 0.933480893270711 -0.0993076015903531 0.596725996358733 1 69.5846 84.12 69.0628 80.7499 GeneID:4695,Genbank:NM_002488.4,HGNC:HGNC:7685,MIM:602137 NADH:ubiquinone oxidoreductase subunit A2 GO:0005747,GO:0032981,GO:0055114 mitochondrial respiratory chain complex I|mitochondrial respiratory chain complex I assembly|oxidation-reduction process hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA3 1653.37818581601 1692.60069409679 1614.15567753524 0.953654150778067 -0.068461937064502 0.696980015954788 1 120.006 131.5 110.856 129.373 GeneID:4696,Genbank:XM_017026833.1,HGNC:HGNC:7686,MIM:603832 NADH:ubiquinone oxidoreductase subunit A3 GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA4 5783.0729896854 5874.05578590803 5692.09019346278 0.969022154525364 -0.0453984448729079 0.851652628580256 1 109.78 128.292 101.507 132.706 GeneID:4697,Genbank:NM_002489.3,HGNC:HGNC:7687,MIM:603833 NDUFA4, mitochondrial complex associated GO:0005739,GO:0005743,GO:0005747,GO:0005751,GO:0006120,GO:0006123,GO:0008137,GO:0032403,GO:0070062,GO:1902600 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial respiratory chain complex IV|mitochondrial electron transport, NADH to ubiquinone|mitochondrial electron transport, cytochrome c to oxygen|NADH dehydrogenase (ubiquinone) activity|protein complex binding|extracellular exosome|hydrogen ion transmembrane transport hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA4L2 29.0891786579167 26.194298366949 31.9840589488843 1.2210313290636 0.288100217282601 0.601682950515377 1 0.89643 0.77536 1.01544 0.705293 GeneID:56901,Genbank:NM_020142.3,HGNC:HGNC:29836 NDUFA4, mitochondrial complex associated like 2 GO:0005751,GO:0022900,GO:1902600 mitochondrial respiratory chain complex IV|electron transport chain|hydrogen ion transmembrane transport hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA5 1044.66733895148 1122.51948545656 966.815192446405 0.8612903428159 -0.215428439691839 0.168269419862539 1 6.51505 5.72752 5.357 5.03531 GeneID:4698,Genbank:NM_001291304.1,HGNC:HGNC:7688,MIM:601677 NADH:ubiquinone oxidoreductase subunit A5 GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0032981 mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA6 1565.82096035662 1499.50478707219 1632.13713364105 1.08845076568767 0.122276151022046 0.40178006924132 1 49.8763 51.8851 54.4462 56.1151 GeneID:4700,Genbank:NM_002490.4,HGNC:HGNC:7690,MIM:602138 NADH:ubiquinone oxidoreductase subunit A6 GO:0005743,GO:0005747,GO:0006120,GO:0006979,GO:0008137,GO:0031966,GO:0032981 mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|mitochondrial membrane|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA7 1217.3273692813 1206.32372919297 1228.33100936963 1.01824326227204 0.0260822680424145 0.946117391982038 1 130.64 145.313 114.598 162.742 GeneID:4701,Genbank:NM_005001.4,HGNC:HGNC:7691,MIM:602139 NADH:ubiquinone oxidoreductase subunit A7 GO:0003735,GO:0005739,GO:0005743,GO:0005747,GO:0005761,GO:0006120,GO:0008137,GO:0032543,GO:0032981 structural constituent of ribosome|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial ribosome|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial translation|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA8 1254.07230125717 1131.87211071589 1376.27249179845 1.21592579123448 0.282055182823493 0.059744424829951 0.879410748501007 27.186 30.9635 35.006 36.8698 GeneID:4702,Genbank:NM_001318195.1,HGNC:HGNC:7692,MIM:603359 NADH:ubiquinone oxidoreductase subunit A8 GO:0005739,GO:0005743,GO:0005747,GO:0005758,GO:0006120,GO:0008137,GO:0032403,GO:0032981 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|protein complex binding|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFA9 1746.41165592208 1718.61945367265 1774.20385817151 1.03234247371056 0.0459216559935671 0.745386713907215 1 47.6533 49.2646 50.6344 49.8486 GeneID:4704,Genbank:NM_005002.4,HGNC:HGNC:7693,MIM:603834 NADH:ubiquinone oxidoreductase subunit A9 GO:0003954,GO:0005634,GO:0005654,GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0006814,GO:0007623,GO:0008137,GO:0031966,GO:0032403,GO:0032981,GO:0050662,GO:1901006 NADH dehydrogenase activity|nucleus|nucleoplasm|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|sodium ion transport|circadian rhythm|NADH dehydrogenase (ubiquinone) activity|mitochondrial membrane|protein complex binding|mitochondrial respiratory chain complex I assembly|coenzyme binding|ubiquinone-6 biosynthetic process hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFAB1 1348.35766092476 1400.5025892234 1296.21273262613 0.925533978016346 -0.111642139890523 0.605982641888067 1 52.9566 54.8944 47.9021 58.4317 GeneID:4706,Genbank:XM_011545856.2,HGNC:HGNC:7694,MIM:603836 NADH:ubiquinone oxidoreductase subunit AB1 GO:0000035,GO:0000036,GO:0005504,GO:0005509,GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0005829,GO:0006120,GO:0006633,GO:0006635,GO:0008137,GO:0009245,GO:0009249,GO:0031177,GO:0031966,GO:0032981,GO:0034641 acyl binding|acyl carrier activity|fatty acid binding|calcium ion binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|cytosol|mitochondrial electron transport, NADH to ubiquinone|fatty acid biosynthetic process|fatty acid beta-oxidation|NADH dehydrogenase (ubiquinone) activity|lipid A biosynthetic process|protein lipoylation|phosphopantetheine binding|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|cellular nitrogen compound metabolic process hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFAF1 617.204724552266 615.095049031133 619.314400073399 1.00685967323085 0.00986262789184916 0.94521387657243 1 16.3932 15.8 15.2393 17.2225 GeneID:51103,Genbank:NM_016013.3,HGNC:HGNC:18828,MIM:606934 NADH:ubiquinone oxidoreductase complex assembly factor 1 GO:0005743,GO:0005747,GO:0005829,GO:0006120,GO:0006461,GO:0032981,GO:0051082 mitochondrial inner membrane|mitochondrial respiratory chain complex I|cytosol|mitochondrial electron transport, NADH to ubiquinone|protein complex assembly|mitochondrial respiratory chain complex I assembly|unfolded protein binding hsa04714 Thermogenesis NDUFAF2 771.889553155662 821.719833210944 722.059273100379 0.878717105170588 -0.186529317069796 0.235466537864523 1 33.2364 38.0118 31.3818 32.4395 GeneID:91942,Genbank:NM_174889.4,HGNC:HGNC:28086,MIM:609653 NADH:ubiquinone oxidoreductase complex assembly factor 2 GO:0005739,GO:0005743,GO:0008137,GO:0009055,GO:0022904,GO:0032981,GO:0045333,GO:0061179,GO:0072593 mitochondrion|mitochondrial inner membrane|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|respiratory electron transport chain|mitochondrial respiratory chain complex I assembly|cellular respiration|negative regulation of insulin secretion involved in cellular response to glucose stimulus|reactive oxygen species metabolic process hsa04714 Thermogenesis NDUFAF3 1663.88144368592 1690.75506134769 1637.00782602415 0.96821110487719 -0.0466064536328455 0.727907421672854 1 51.0876 53.6848 49.7573 52.5215 GeneID:25915,Genbank:NM_199074.1,HGNC:HGNC:29918,MIM:612911 NADH:ubiquinone oxidoreductase complex assembly factor 3 GO:0005634,GO:0005743,GO:0032981 nucleus|mitochondrial inner membrane|mitochondrial respiratory chain complex I assembly hsa04714 Thermogenesis NDUFAF4 429.916030126277 496.375342245322 363.456718007232 0.732221540987832 -0.449647878443493 0.0131824944019808 0.471274174870813 8.41196 8.65366 6.23929 6.45421 GeneID:29078,Genbank:NM_014165.3,HGNC:HGNC:21034,MIM:611776 NADH:ubiquinone oxidoreductase complex assembly factor 4 GO:0005516,GO:0005739,GO:0005743,GO:0031966,GO:0032981 calmodulin binding|mitochondrion|mitochondrial inner membrane|mitochondrial membrane|mitochondrial respiratory chain complex I assembly hsa04714 Thermogenesis NDUFAF5 222.617390494696 234.912621322681 210.322159666711 0.895320815384403 -0.159523366889263 0.481673300049388 1 2.0202 1.81622 1.68266 1.6602 GeneID:79133,Genbank:NM_001352407.1,HGNC:HGNC:15899,MIM:612360 NADH:ubiquinone oxidoreductase complex assembly factor 5 GO:0005739,GO:0005743,GO:0008168,GO:0016491,GO:0030961,GO:0031314,GO:0032981 mitochondrion|mitochondrial inner membrane|methyltransferase activity|oxidoreductase activity|peptidyl-arginine hydroxylation|extrinsic component of mitochondrial inner membrane|mitochondrial respiratory chain complex I assembly hsa04714 Thermogenesis NDUFAF6 240.998893210206 260.520795738303 221.476990682109 0.850131714262786 -0.234241713881224 0.281190303157793 1 1.26734 1.07903 1.04409 1.1016 GeneID:137682,Genbank:NM_001354534.1,HGNC:HGNC:28625,MIM:612392 NADH:ubiquinone oxidoreductase complex assembly factor 6 GO:0005634,GO:0005737,GO:0005743,GO:0009058,GO:0016740,GO:0032981 nucleus|cytoplasm|mitochondrial inner membrane|biosynthetic process|transferase activity|mitochondrial respiratory chain complex I assembly hsa04714 Thermogenesis NDUFAF7 320.425102115201 326.323616768682 314.526587461719 0.963848680571211 -0.0531214265703249 0.804314833299898 1 2.51647 2.40448 2.49189 2.31889 GeneID:55471,Genbank:NM_144736.4,HGNC:HGNC:28816,MIM:615898 NADH:ubiquinone oxidoreductase complex assembly factor 7 GO:0005615,GO:0005739,GO:0005759,GO:0008168,GO:0019899,GO:0019918,GO:0032981,GO:0035243,GO:0046034 extracellular space|mitochondrion|mitochondrial matrix|methyltransferase activity|enzyme binding|peptidyl-arginine methylation, to symmetrical-dimethyl arginine|mitochondrial respiratory chain complex I assembly|protein-arginine omega-N symmetric methyltransferase activity|ATP metabolic process hsa04714 Thermogenesis NDUFAF8 645.57366487314 677.170420945447 613.976908800833 0.906680046573232 -0.141334559191402 0.386398177841568 1 32.7549 32.891 31.1177 32.292 GeneID:284184,Genbank:NM_001353403.1,HGNC:HGNC:33551 NADH:ubiquinone oxidoreductase complex assembly factor 8 GO:0005739,GO:0032981 mitochondrion|mitochondrial respiratory chain complex I assembly NDUFB1 826.423934300995 848.499238528365 804.348630073625 0.947966236797908 -0.0770924185398309 0.791363337552121 1 147.988 134.666 114.772 157.86 GeneID:4707,Genbank:NM_004545.3,HGNC:HGNC:7695,MIM:603837 NADH:ubiquinone oxidoreductase subunit B1 GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0016607,GO:0032981,GO:0070062 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|nuclear speck|mitochondrial respiratory chain complex I assembly|extracellular exosome hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFB10 1903.51325762176 1866.7356699225 1940.29084532102 1.03940310167297 0.0557552692575123 0.75855495248849 1 85.6503 91.9098 83.5821 99.797 GeneID:4716,Genbank:NM_004548.2,HGNC:HGNC:7696,MIM:603843 NADH:ubiquinone oxidoreductase subunit B10 GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0032981,GO:0070062 mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly|extracellular exosome hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFB11 1919.79079085376 1909.87176194986 1929.70981975766 1.01038711509486 0.0149081464676428 0.948292700963707 1 54.4734 58.4938 58.8105 60.5722 GeneID:54539,Genbank:NM_001135998.2,HGNC:HGNC:20372,MIM:300403 NADH:ubiquinone oxidoreductase subunit B11 GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0016021,GO:0032981 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|integral component of membrane|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFB2 2564.38439790453 2609.90406799963 2518.86472780942 0.965117744630365 -0.0512231325772886 0.795535598002588 1 327.778 382.059 318.19 369.645 GeneID:4708,Genbank:NM_004546.2,HGNC:HGNC:7697,MIM:603838 NADH:ubiquinone oxidoreductase subunit B2 GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0032981 mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFB3 1173.46591480218 1202.86176941224 1144.07006019212 0.951123470115064 -0.0722954581545803 0.749522424075591 1 20.982 19.6153 17.0773 21.7835 GeneID:4709,Genbank:NM_001257102.1,HGNC:HGNC:7698,MIM:603839 NADH:ubiquinone oxidoreductase subunit B3 GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981,GO:0070062 mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly|extracellular exosome hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFB4 3631.21432327275 3706.97805817398 3555.45058837152 0.959123720878697 -0.0602111691272517 0.664792767142055 1 114.33 124.347 109.542 121.974 GeneID:4710,Genbank:NM_001168331.1,HGNC:HGNC:7699,MIM:603840 NADH:ubiquinone oxidoreductase subunit B4 GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0006979,GO:0008137,GO:0016021,GO:0031965,GO:0032981,GO:0070062 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|nuclear membrane|mitochondrial respiratory chain complex I assembly|extracellular exosome hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFB5 2328.74978010328 2339.75026400729 2317.74929619928 0.990596873458482 -0.0136300273705787 0.935499896193388 1 103.899 112.038 98.6591 115.427 GeneID:4711,Genbank:NM_002492.3,HGNC:HGNC:7700,MIM:603841 NADH:ubiquinone oxidoreductase subunit B5 GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981 nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFB6 1209.60956616914 1215.53699927909 1203.68213305919 0.99024721894362 -0.01413935048368 0.946816757119734 1 66.6839 68.0436 61.3932 73.0821 GeneID:4712,Genbank:NM_001199987.1,HGNC:HGNC:7701,MIM:603322 NADH:ubiquinone oxidoreductase subunit B6 GO:0005747,GO:0016021,GO:0032981,GO:0055114 mitochondrial respiratory chain complex I|integral component of membrane|mitochondrial respiratory chain complex I assembly|oxidation-reduction process hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFB7 2158.86625004793 2188.56341718016 2129.1690829157 0.97286149727341 -0.0396936664685875 0.861011520774228 1 32.0334 35.1206 31.8988 39.8707 GeneID:4713,Genbank:NM_004146.5,HGNC:HGNC:7702,MIM:603842 NADH:ubiquinone oxidoreductase subunit B7 GO:0005739,GO:0005743,GO:0005747,GO:0005758,GO:0006120,GO:0008137,GO:0032981 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFB8 2872.16631623869 2986.05904628709 2758.27358619029 0.923717027504854 -0.114477132358453 0.496599198748059 1 81.7697 88.8197 75.2098 85.9884 GeneID:4714,Genbank:NM_001284368.1,HGNC:HGNC:7703,MIM:602140 NADH:ubiquinone oxidoreductase subunit B8 GO:0005739,GO:0005743,GO:0005747,GO:0005759,GO:0005783,GO:0006120,GO:0006626,GO:0008137,GO:0016021,GO:0032981 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial matrix|endoplasmic reticulum|mitochondrial electron transport, NADH to ubiquinone|protein targeting to mitochondrion|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFB9 2673.3889620206 2840.02859415976 2506.74932988143 0.882649327910401 -0.180087718587398 0.273823271879761 1 177.749 191.519 150.31 178.853 GeneID:4715,Genbank:NM_005005.2,HGNC:HGNC:7704,MIM:601445 NADH:ubiquinone oxidoreductase subunit B9 GO:0005747,GO:0006120,GO:0032981 mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFC1 999.590666579641 1043.12116068692 956.060172472361 0.916537990507999 -0.125733413160319 0.535292769097167 1 26.9849 25.8598 20.9134 26.7919 GeneID:4717,Genbank:NM_001184990.1,HGNC:HGNC:7705,MIM:603844 NADH:ubiquinone oxidoreductase subunit C1 GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0016021,GO:0032981 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFC2 291.580718133049 293.874060035873 289.287376230225 0.984392348868466 -0.0226946503099189 0.923848883314416 1 43.8928 50.0017 42.1084 44.6299 GeneID:4718,Genbank:NM_001204055.1,HGNC:HGNC:7706,MIM:603845 NADH:ubiquinone oxidoreductase subunit C2 GO:0005739,GO:0005743,GO:0006120,GO:0008137,GO:0016021,GO:0070469 mitochondrion|mitochondrial inner membrane|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|integral component of membrane|respiratory chain hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFS1 2603.23539252743 2581.17687537861 2625.29390967624 1.01709182920336 0.0244499403119251 0.855637901388968 1 23.9252 23.8462 26.0436 23.1087 GeneID:4719,Genbank:NM_001199982.1,HGNC:HGNC:7707,MIM:157655 NADH:ubiquinone oxidoreductase core subunit S1 GO:0005739,GO:0005747,GO:0005758,GO:0005759,GO:0006120,GO:0008137,GO:0008637,GO:0009055,GO:0032981,GO:0043209,GO:0045333,GO:0046034,GO:0046872,GO:0051536,GO:0051537,GO:0051539,GO:0051881,GO:0072593 mitochondrion|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|apoptotic mitochondrial changes|electron transfer activity|mitochondrial respiratory chain complex I assembly|myelin sheath|cellular respiration|ATP metabolic process|metal ion binding|iron-sulfur cluster binding|2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|regulation of mitochondrial membrane potential|reactive oxygen species metabolic process hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFS2 2944.29667487957 2680.60353504617 3207.98981471297 1.19674161910621 0.259111702764383 0.098668238009227 1 33.6116 34.465 39.4388 44.4034 GeneID:4720,Genbank:NM_004550.4,HGNC:HGNC:7708,MIM:602985 NADH:ubiquinone oxidoreductase core subunit S2 GO:0005654,GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0006979,GO:0008137,GO:0009055,GO:0031625,GO:0032981,GO:0042775,GO:0046872,GO:0048038,GO:0051287,GO:0051539 nucleoplasm|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|ubiquitin protein ligase binding|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport|metal ion binding|quinone binding|NAD binding|4 iron, 4 sulfur cluster binding hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFS3 2119.64609671033 2155.05524840257 2084.23694501809 0.967138520723786 -0.0482055569442162 0.719401235783861 1 101.115 105.714 94.8118 107.62 GeneID:4722,Genbank:NM_004551.2,HGNC:HGNC:7710,MIM:603846 NADH:ubiquinone oxidoreductase core subunit S3 GO:0003954,GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0008137,GO:0009055,GO:0016604,GO:0021762,GO:0030308,GO:0031966,GO:0032981,GO:0043209,GO:0045333,GO:0072593,GO:2001243 NADH dehydrogenase activity|mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|nuclear body|substantia nigra development|negative regulation of cell growth|mitochondrial membrane|mitochondrial respiratory chain complex I assembly|myelin sheath|cellular respiration|reactive oxygen species metabolic process|negative regulation of intrinsic apoptotic signaling pathway hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFS4 1045.66958448177 1028.1406696352 1063.19849932833 1.03409828122603 0.0483733066386308 0.743303918077069 1 21.2955 19.9194 22.0464 24.6339 GeneID:4724,Genbank:XM_017009491.1,HGNC:HGNC:7711,MIM:602694 NADH:ubiquinone oxidoreductase subunit S4 GO:0005747,GO:0007420,GO:0016651,GO:0019933,GO:0022900,GO:0032981,GO:0045333,GO:0048146,GO:0051591,GO:0072593 mitochondrial respiratory chain complex I|brain development|oxidoreductase activity, acting on NAD(P)H|cAMP-mediated signaling|electron transport chain|mitochondrial respiratory chain complex I assembly|cellular respiration|positive regulation of fibroblast proliferation|response to cAMP|reactive oxygen species metabolic process hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFS5 4688.45263162069 4745.12105260132 4631.78421064005 0.976115078897906 -0.034876850820239 0.788564105829404 1 265.689 280.748 247.787 275.332 GeneID:4725,Genbank:NM_004552.2,HGNC:HGNC:7712,MIM:603847 NADH:ubiquinone oxidoreductase subunit S5 GO:0005739,GO:0005743,GO:0005747,GO:0005758,GO:0006120,GO:0008137,GO:0032981 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial intermembrane space|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFS6 3879.42021521001 3766.8618047613 3991.97862565873 1.05976243158506 0.0837408900834333 0.660680391107885 1 359.775 380.705 367.038 420.164 GeneID:4726,Genbank:NM_004553.4,HGNC:HGNC:7713,MIM:603848 NADH:ubiquinone oxidoreductase subunit S6 GO:0005743,GO:0005747,GO:0006120,GO:0006631,GO:0006936,GO:0008137,GO:0009055,GO:0010259,GO:0032981,GO:0035264,GO:0061458,GO:0070584,GO:0072358 mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|fatty acid metabolic process|muscle contraction|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|multicellular organism aging|mitochondrial respiratory chain complex I assembly|multicellular organism growth|reproductive system development|mitochondrion morphogenesis|cardiovascular system development hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFS7 1629.40898937244 1616.01630222335 1642.80167652154 1.01657494064963 0.0237165728003345 0.899803500007893 1 8.58417 8.92253 8.89565 8.4271 GeneID:374291,Genbank:NM_024407.4,HGNC:HGNC:7714,MIM:601825 NADH:ubiquinone oxidoreductase core subunit S7 GO:0002020,GO:0005747,GO:0005759,GO:0006120,GO:0008137,GO:0016655,GO:0032981,GO:0043005,GO:0043025,GO:0046872,GO:0048038,GO:0051539,GO:0097060 protease binding|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|mitochondrial respiratory chain complex I assembly|neuron projection|neuronal cell body|metal ion binding|quinone binding|4 iron, 4 sulfur cluster binding|synaptic membrane hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFS8 2191.40138378114 2189.0839315483 2193.71883601398 1.00211728038331 0.00305136075474088 0.985840665385786 1 145.909 169.246 147.436 170.301 GeneID:4728,Genbank:NM_002496.3,HGNC:HGNC:7715,MIM:602141 NADH:ubiquinone oxidoreductase core subunit S8 GO:0005739,GO:0005747,GO:0005759,GO:0006120,GO:0006979,GO:0008137,GO:0032981,GO:0046872,GO:0051539 mitochondrion|mitochondrial respiratory chain complex I|mitochondrial matrix|mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly|metal ion binding|4 iron, 4 sulfur cluster binding hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFV1 2800.05325687654 2688.19677145066 2911.90974230241 1.08322045961354 0.115326893567861 0.509932885855088 1 64.9844 70.6439 70.2089 79.4154 GeneID:4723,Genbank:NM_007103.3,HGNC:HGNC:7716,MIM:161015 NADH:ubiquinone oxidoreductase core subunit V1 GO:0005739,GO:0005743,GO:0005747,GO:0005829,GO:0006120,GO:0008137,GO:0010181,GO:0032981,GO:0042775,GO:0046872,GO:0051287,GO:0051539 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|cytosol|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|FMN binding|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport|metal ion binding|NAD binding|4 iron, 4 sulfur cluster binding hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFV2 3316.50036742156 3252.92911893892 3380.0716159042 1.03908554177374 0.0553144276904221 0.690417120484038 1 64.682 70.8931 67.253 75.8663 GeneID:4729,Genbank:NM_021074.4,HGNC:HGNC:7717,MIM:600532 NADH:ubiquinone oxidoreductase core subunit V2 GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0007399,GO:0008137,GO:0009055,GO:0032981,GO:0043209,GO:0046872,GO:0048738,GO:0051537 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|nervous system development|NADH dehydrogenase (ubiquinone) activity|electron transfer activity|mitochondrial respiratory chain complex I assembly|myelin sheath|metal ion binding|cardiac muscle tissue development|2 iron, 2 sulfur cluster binding hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NDUFV3 725.332339746682 718.882291039907 731.782388453458 1.01794465877702 0.025659130491991 0.860056602616976 1 4.90778 4.6001 5.37695 4.87428 GeneID:4731,Genbank:NM_021075.3,HGNC:HGNC:7719,MIM:602184 NADH:ubiquinone oxidoreductase subunit V3 GO:0003723,GO:0005654,GO:0005739,GO:0005743,GO:0005747,GO:0006120,GO:0008137,GO:0032981,GO:0042775 RNA binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex I|mitochondrial electron transport, NADH to ubiquinone|NADH dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex I assembly|mitochondrial ATP synthesis coupled electron transport hsa00190,hsa04714,hsa04723,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Thermogenesis|Retrograde endocannabinoid signaling|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease NEB 3.21597953961212 3.03648096111406 3.39547811811019 1.11822802829774 0.161214411570942 1 1 0.00211125 0.002968 0.00403775 0 GeneID:4703,Genbank:XM_011511227.2,HGNC:HGNC:7720,MIM:161650 nebulin GO:0003779,GO:0005829,GO:0007517,GO:0007525,GO:0008307,GO:0015629,GO:0030018,GO:0030049,GO:0030832,GO:0070062 actin binding|cytosol|muscle organ development|somatic muscle development|structural constituent of muscle|actin cytoskeleton|Z disc|muscle filament sliding|regulation of actin filament length|extracellular exosome NEBL 174.920186003955 164.199277617621 185.641094390289 1.13058411147582 0.177068327511847 0.558307229201058 1 0.542158 0.440228 0.633072 0.439579 GeneID:10529,Genbank:NM_001173484.1,HGNC:HGNC:16932,MIM:605491 nebulette GO:0003779,GO:0005737,GO:0046872 actin binding|cytoplasm|metal ion binding NECAB1 6.0962993196137 7.83133377620985 4.36126486301754 0.556899372143512 -0.844511428766987 0.533277777560034 1 0.0415279 0.0246297 0.0241649 0.0225009 GeneID:64168,Genbank:NM_022351.4,HGNC:HGNC:20983 N-terminal EF-hand calcium binding protein 1 GO:0005509,GO:0005634,GO:0005654,GO:0005737,GO:0005829 calcium ion binding|nucleus|nucleoplasm|cytoplasm|cytosol NECAB2 1.02273099320278 1.07619535328461 0.969266633120943 0.900641904987498 -0.150974490057726 1 1 0.0378538 0 0.0176344 0.0164553 GeneID:54550,Genbank:NM_019065.2,HGNC:HGNC:23746 N-terminal EF-hand calcium binding protein 2 GO:0005509,GO:0005737,GO:0005886,GO:0030424,GO:0030425,GO:0031687,GO:0031802,GO:0042802,GO:0060168,GO:0070374,GO:1900451,GO:1904021,GO:1905477 calcium ion binding|cytoplasm|plasma membrane|axon|dendrite|A2A adenosine receptor binding|type 5 metabotropic glutamate receptor binding|identical protein binding|positive regulation of adenosine receptor signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of glutamate receptor signaling pathway|negative regulation of G-protein coupled receptor internalization|positive regulation of protein localization to membrane NECAB3 898.865543824938 867.776736339828 929.954351310047 1.07165162692938 0.0998359899518341 0.545061389139872 1 11.3947 13.464 13.8227 15.4515 GeneID:63941,Genbank:NM_031231.3,HGNC:HGNC:15851,MIM:612478 N-terminal EF-hand calcium binding protein 3 GO:0000137,GO:0005509,GO:0005634,GO:0005737,GO:0005789,GO:0005794,GO:0009306,GO:0019538,GO:0042984 Golgi cis cisterna|calcium ion binding|nucleus|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|protein secretion|protein metabolic process|regulation of amyloid precursor protein biosynthetic process NECAP1 812.062815470398 789.096771688756 835.028859252039 1.05820843426464 0.0816238216513838 0.615157360712921 1 12.2954 13.2917 14.3068 13.3737 GeneID:25977,Genbank:NM_015509.3,HGNC:HGNC:24539,MIM:611623 NECAP endocytosis associated 1 GO:0005829,GO:0005886,GO:0005905,GO:0006897,GO:0015031,GO:0030125,GO:0061024 cytosol|plasma membrane|clathrin-coated pit|endocytosis|protein transport|clathrin vesicle coat|membrane organization NECAP2 1667.13120878467 1674.53467880841 1659.72773876094 0.991157579335407 -0.0128136521546865 0.918490531902155 1 21.3335 23.0484 21.0471 23.8489 GeneID:55707,Genbank:NM_018090.4,HGNC:HGNC:25528,MIM:611624 NECAP endocytosis associated 2 GO:0005622,GO:0005886,GO:0005905,GO:0006897,GO:0015031,GO:0030125 intracellular|plasma membrane|clathrin-coated pit|endocytosis|protein transport|clathrin vesicle coat NECTIN1 498.520615447937 552.205264448884 444.835966446989 0.805562704823082 -0.311931202521177 0.211967594483832 1 2.82737 3.34519 2.29474 2.83658 GeneID:5818,Genbank:NM_203285.1,HGNC:HGNC:9706,MIM:600644 nectin cell adhesion molecule 1 GO:0001618,GO:0002089,GO:0002934,GO:0005102,GO:0005576,GO:0005886,GO:0005887,GO:0005912,GO:0005913,GO:0006826,GO:0006955,GO:0007155,GO:0007156,GO:0007157,GO:0007411,GO:0008037,GO:0015026,GO:0016020,GO:0016021,GO:0016342,GO:0030246,GO:0030424,GO:0032584,GO:0034332,GO:0042734,GO:0042802,GO:0042803,GO:0043231,GO:0043296,GO:0044291,GO:0046718,GO:0046790,GO:0046982,GO:0050839,GO:0051963,GO:0060041,GO:0070166,GO:0098609,GO:1902414 virus receptor activity|lens morphogenesis in camera-type eye|desmosome organization|receptor binding|extracellular region|plasma membrane|integral component of plasma membrane|adherens junction|cell-cell adherens junction|iron ion transport|immune response|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|axon guidance|cell recognition|coreceptor activity|membrane|integral component of membrane|catenin complex|carbohydrate binding|axon|growth cone membrane|adherens junction organization|presynaptic membrane|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|apical junction complex|cell-cell contact zone|viral entry into host cell|virion binding|protein heterodimerization activity|cell adhesion molecule binding|regulation of synapse assembly|retina development in camera-type eye|enamel mineralization|cell-cell adhesion|protein localization to cell junction hsa04514,hsa04520,hsa05168 Cell adhesion molecules (CAMs)|Adherens junction|Herpes simplex infection NECTIN2 3089.84488934304 2895.33022734179 3284.35955134429 1.13436440525116 0.181884168672701 0.192830175046575 1 25.9617 28.4441 32.272 30.605 GeneID:5819,Genbank:NM_001042724.1,HGNC:HGNC:9707,MIM:600798 nectin cell adhesion molecule 2 GO:0001618,GO:0001675,GO:0002860,GO:0002891,GO:0005102,GO:0005886,GO:0005887,GO:0005911,GO:0005913,GO:0005915,GO:0005925,GO:0007010,GO:0007156,GO:0007157,GO:0007286,GO:0007289,GO:0008037,GO:0009566,GO:0009986,GO:0015026,GO:0016021,GO:0019064,GO:0030382,GO:0032990,GO:0033005,GO:0034332,GO:0042271,GO:0042802,GO:0042803,GO:0044291,GO:0044406,GO:0044782,GO:0045954,GO:0046596,GO:0046814,GO:0046982,GO:0050776,GO:0050839,GO:0050862,GO:0051654,GO:0060370,GO:0070062 virus receptor activity|acrosome assembly|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of immunoglobulin mediated immune response|receptor binding|plasma membrane|integral component of plasma membrane|cell-cell junction|cell-cell adherens junction|zonula adherens|focal adhesion|cytoskeleton organization|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|spermatid development|spermatid nucleus differentiation|cell recognition|fertilization|cell surface|coreceptor activity|integral component of membrane|fusion of virus membrane with host plasma membrane|sperm mitochondrion organization|cell part morphogenesis|positive regulation of mast cell activation|adherens junction organization|susceptibility to natural killer cell mediated cytotoxicity|identical protein binding|protein homodimerization activity|cell-cell contact zone|adhesion of symbiont to host|cilium organization|positive regulation of natural killer cell mediated cytotoxicity|regulation of viral entry into host cell|coreceptor-mediated virion attachment to host cell|protein heterodimerization activity|regulation of immune response|cell adhesion molecule binding|positive regulation of T cell receptor signaling pathway|establishment of mitochondrion localization|susceptibility to T cell mediated cytotoxicity|extracellular exosome hsa04514,hsa04520,hsa05168 Cell adhesion molecules (CAMs)|Adherens junction|Herpes simplex infection NECTIN3 809.491472873431 796.868236533464 822.114709213399 1.03168211697051 0.0449985144468086 0.894967601705979 1 2.69133 2.25392 3.28546 1.84984 GeneID:25945,Genbank:NM_015480.2,HGNC:HGNC:17664,MIM:607147 nectin cell adhesion molecule 3 GO:0002089,GO:0004872,GO:0005102,GO:0005886,GO:0005887,GO:0005913,GO:0007156,GO:0007157,GO:0007286,GO:0008037,GO:0009566,GO:0034332,GO:0042802,GO:0042803,GO:0043296,GO:0044291,GO:0045211,GO:0046982,GO:0050839,GO:0060042,GO:1902414 lens morphogenesis in camera-type eye|receptor activity|receptor binding|plasma membrane|integral component of plasma membrane|cell-cell adherens junction|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|spermatid development|cell recognition|fertilization|adherens junction organization|identical protein binding|protein homodimerization activity|apical junction complex|cell-cell contact zone|postsynaptic membrane|protein heterodimerization activity|cell adhesion molecule binding|retina morphogenesis in camera-type eye|protein localization to cell junction hsa04514,hsa04520 Cell adhesion molecules (CAMs)|Adherens junction NECTIN4 5.05586324651874 7.68725495215503 2.42447154088245 0.315388465189747 -1.66479819797346 0.239095050314656 1 0.0818988 0.0846324 0.0256101 0.0119398 GeneID:81607,Genbank:NM_030916.2,HGNC:HGNC:19688,MIM:609607 nectin cell adhesion molecule 4 hsa04520 Adherens junction NEDD1 389.761925834187 409.70034768377 369.823503984603 0.902668269810828 -0.147732199571085 0.693818002054712 1 4.28501 3.31936 4.13156 2.71917 GeneID:121441,Genbank:XM_017018801.2,HGNC:HGNC:7723,MIM:600372 neural precursor cell expressed, developmentally down-regulated 1 GO:0000086,GO:0000242,GO:0000922,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0036064,GO:0045177,GO:0051301,GO:0071539,GO:0097711 G2/M transition of mitotic cell cycle|pericentriolar material|spindle pole|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|ciliary basal body|apical part of cell|cell division|protein localization to centrosome|ciliary basal body-plasma membrane docking NEDD4 392.804581838529 492.857581536504 292.751582140554 0.593988188693149 -0.751493851206841 0.00190496189374551 0.155161689175677 2.04924 1.69615 1.32899 0.906764 GeneID:4734,Genbank:NM_006154.3,HGNC:HGNC:7727,MIM:602278 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase GO:0000151,GO:0000785,GO:0002250,GO:0003151,GO:0003197,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0005938,GO:0006513,GO:0006622,GO:0007041,GO:0007528,GO:0010766,GO:0010768,GO:0014068,GO:0016241,GO:0016327,GO:0016567,GO:0019089,GO:0019871,GO:0019904,GO:0030948,GO:0031175,GO:0031623,GO:0031698,GO:0032801,GO:0034644,GO:0034765,GO:0035255,GO:0042110,GO:0042391,GO:0042787,GO:0042921,GO:0043130,GO:0043162,GO:0043197,GO:0044111,GO:0045732,GO:0046824,GO:0048471,GO:0048514,GO:0048814,GO:0050807,GO:0050815,GO:0050816,GO:0050847,GO:0051592,GO:0061630,GO:0070062,GO:0070063,GO:0070064,GO:0070534,GO:1901016,GO:2000650 ubiquitin ligase complex|chromatin|adaptive immune response|outflow tract morphogenesis|endocardial cushion development|cytoplasm|Golgi apparatus|cytosol|plasma membrane|cell cortex|protein monoubiquitination|protein targeting to lysosome|lysosomal transport|neuromuscular junction development|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of macroautophagy|apicolateral plasma membrane|protein ubiquitination|transmission of virus|sodium channel inhibitor activity|protein domain specific binding|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|receptor internalization|beta-2 adrenergic receptor binding|receptor catabolic process|cellular response to UV|regulation of ion transmembrane transport|ionotropic glutamate receptor binding|T cell activation|regulation of membrane potential|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|glucocorticoid receptor signaling pathway|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|dendritic spine|development involved in symbiotic interaction|positive regulation of protein catabolic process|positive regulation of nucleocytoplasmic transport|perinuclear region of cytoplasm|blood vessel morphogenesis|regulation of dendrite morphogenesis|regulation of synapse organization|phosphoserine residue binding|phosphothreonine residue binding|progesterone receptor signaling pathway|response to calcium ion|ubiquitin protein ligase activity|extracellular exosome|RNA polymerase binding|proline-rich region binding|protein K63-linked ubiquitination|regulation of potassium ion transmembrane transporter activity|negative regulation of sodium ion transmembrane transporter activity hsa04120,hsa04144,hsa04530,hsa05169 Ubiquitin mediated proteolysis|Endocytosis|Tight junction|Epstein-Barr virus infection NEDD4L 559.238666886376 515.074490758856 603.402843013896 1.17148655940019 0.228340402090139 0.176921182247303 1 1.42195 1.36631 1.91085 1.55005 GeneID:23327,Genbank:XM_006722426.4,HGNC:HGNC:7728,MIM:606384 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase GO:0000122,GO:0000209,GO:0003254,GO:0004842,GO:0005622,GO:0005654,GO:0005737,GO:0005771,GO:0005794,GO:0005829,GO:0006513,GO:0006814,GO:0006883,GO:0007588,GO:0010038,GO:0015459,GO:0016567,GO:0017080,GO:0019058,GO:0019870,GO:0019871,GO:0030104,GO:0034220,GO:0034765,GO:0042176,GO:0042391,GO:0042787,GO:0043161,GO:0044325,GO:0045732,GO:0045807,GO:0060306,GO:0061630,GO:0070062,GO:0070936,GO:0086005,GO:1901016,GO:1901017,GO:1901380,GO:1902306,GO:1903861,GO:2000009,GO:2000650,GO:2001288 negative regulation of transcription from RNA polymerase II promoter|protein polyubiquitination|regulation of membrane depolarization|ubiquitin-protein transferase activity|intracellular|nucleoplasm|cytoplasm|multivesicular body|Golgi apparatus|cytosol|protein monoubiquitination|sodium ion transport|cellular sodium ion homeostasis|excretion|response to metal ion|potassium channel regulator activity|protein ubiquitination|sodium channel regulator activity|viral life cycle|potassium channel inhibitor activity|sodium channel inhibitor activity|water homeostasis|ion transmembrane transport|regulation of ion transmembrane transport|regulation of protein catabolic process|regulation of membrane potential|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ion channel binding|positive regulation of protein catabolic process|positive regulation of endocytosis|regulation of membrane repolarization|ubiquitin protein ligase activity|extracellular exosome|protein K48-linked ubiquitination|ventricular cardiac muscle cell action potential|regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transport|negative regulation of sodium ion transmembrane transport|positive regulation of dendrite extension|negative regulation of protein localization to cell surface|negative regulation of sodium ion transmembrane transporter activity|positive regulation of caveolin-mediated endocytosis hsa04120,hsa04144,hsa04530,hsa04960 Ubiquitin mediated proteolysis|Endocytosis|Tight junction|Aldosterone-regulated sodium reabsorption NEDD8 956.436153992441 931.609463107269 981.262844877612 1.05329849441925 0.0749143398712846 0.744439103265739 1 168.136 183.182 161.323 190.966 GeneID:4738,Genbank:NM_006156.2,HGNC:HGNC:7732,MIM:603171 neural precursor cell expressed, developmentally down-regulated 8 GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006464,GO:0006508,GO:0006511,GO:0006879,GO:0007179,GO:0008104,GO:0009653,GO:0014070,GO:0016567,GO:0016579,GO:0031625,GO:0043687,GO:0045116,GO:0070062 nucleus|nucleoplasm|cytosol|regulation of transcription from RNA polymerase II promoter|cellular protein modification process|proteolysis|ubiquitin-dependent protein catabolic process|cellular iron ion homeostasis|transforming growth factor beta receptor signaling pathway|protein localization|anatomical structure morphogenesis|response to organic cyclic compound|protein ubiquitination|protein deubiquitination|ubiquitin protein ligase binding|post-translational protein modification|protein neddylation|extracellular exosome NEDD9 4812.02113846774 4694.83376929674 4929.20850763874 1.04992183959201 0.0702819318627249 0.590706420023706 1 28.709 27.6207 30.8617 28.7243 GeneID:4739,Genbank:NM_001142393.1,HGNC:HGNC:7733,MIM:602265 neural precursor cell expressed, developmentally down-regulated 9 GO:0000922,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005819,GO:0005829,GO:0005886,GO:0005925,GO:0005938,GO:0007010,GO:0007049,GO:0007155,GO:0007165,GO:0007229,GO:0030027,GO:0040008,GO:0051017,GO:0051301 spindle pole|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|spindle|cytosol|plasma membrane|focal adhesion|cell cortex|cytoskeleton organization|cell cycle|cell adhesion|signal transduction|integrin-mediated signaling pathway|lamellipodium|regulation of growth|actin filament bundle assembly|cell division NEFL 42450.6828521013 42317.7486139527 42583.6170902499 1.00628267062888 0.00903562346489285 0.939950964453342 1 417.934 413.041 441.951 402.55 GeneID:4747,Genbank:NM_006158.4,HGNC:HGNC:7739,MIM:162280 neurofilament light hsa05014 Amyotrophic lateral sclerosis (ALS) NEFM 6.46987078869371 4.69880026572591 8.24094131166151 1.75383945807885 0.810516693259386 0.507751274645227 1 0.0484782 0.0150757 0.0614756 0.0428556 GeneID:4741,Genbank:NM_005382.2,HGNC:HGNC:7734,MIM:162250 neurofilament medium hsa05014 Amyotrophic lateral sclerosis (ALS) NEGR1 155.993597877656 152.995278957503 158.99191679781 1.03919492079212 0.0554662845455387 0.874120751691167 1 0.603264 0.542511 0.77958 0.414323 GeneID:257194,Genbank:NM_173808.2,HGNC:HGNC:17302,MIM:613173 neuronal growth regulator 1 GO:0005576,GO:0005886,GO:0006501,GO:0007626,GO:0007631,GO:0010976,GO:0031225,GO:0070062,GO:0098609 extracellular region|plasma membrane|C-terminal protein lipidation|locomotory behavior|feeding behavior|positive regulation of neuron projection development|anchored component of membrane|extracellular exosome|cell-cell adhesion hsa04514 Cell adhesion molecules (CAMs) NEIL1 37.4806392385384 32.3152865638621 42.6459919132147 1.31968478227593 0.400193370981484 0.399099887852443 1 0.104201 0.245697 0.275542 0.283866 GeneID:79661,Genbank:XM_011522003.3,HGNC:HGNC:18448,MIM:608844 nei like DNA glycosylase 1 hsa03410 Base excision repair NEIL2 418.779479369066 440.6621069022 396.896851835931 0.900682962340617 -0.150908723753355 0.410364897672745 1 6.93656 6.80096 6.20437 6.60112 GeneID:252969,Genbank:NM_001349440.1,HGNC:HGNC:18956,MIM:608933 nei like DNA glycosylase 2 hsa03410 Base excision repair NEIL3 400.032728723372 405.050590693584 395.01486675316 0.975223529675049 -0.036195159930071 0.863472831505376 1 6.9999 6.8229 7.5631 5.55403 GeneID:55247,Genbank:NM_018248.2,HGNC:HGNC:24573,MIM:608934 nei like DNA glycosylase 3 hsa03410 Base excision repair NEK1 69.3039049029957 64.4384680289844 74.169341777007 1.15101032109649 0.202900770158203 0.700185240561949 1 0.215066 0.28587 0.381967 0.194223 GeneID:4750,Genbank:XM_017008251.1,HGNC:HGNC:7744,MIM:604588 NIMA related kinase 1 GO:0000242,GO:0004672,GO:0004674,GO:0004713,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0006468,GO:0007049,GO:0007346,GO:0016301,GO:0023014,GO:0031098,GO:0032147,GO:0042769,GO:0042981,GO:0046872,GO:0051301,GO:0060271,GO:0071889 pericentriolar material|protein kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|centrosome|protein phosphorylation|cell cycle|regulation of mitotic cell cycle|kinase activity|signal transduction by protein phosphorylation|stress-activated protein kinase signaling cascade|activation of protein kinase activity|DNA damage response, detection of DNA damage|regulation of apoptotic process|metal ion binding|cell division|cilium assembly|14-3-3 protein binding NEK10 27.560424033166 29.9129558287602 25.2078922375717 0.842708169058145 -0.246894984413475 0.682030292669994 1 0.0502857 0.0448944 0.0467674 0.0217373 GeneID:152110,Genbank:XM_017005772.2,HGNC:HGNC:18592 NIMA related kinase 10 GO:0004672,GO:0004674,GO:0005524,GO:0006468,GO:0031954,GO:0043406,GO:0046872,GO:0070372,GO:1902749,GO:1902911 protein kinase activity|protein serine/threonine kinase activity|ATP binding|protein phosphorylation|positive regulation of protein autophosphorylation|positive regulation of MAP kinase activity|metal ion binding|regulation of ERK1 and ERK2 cascade|regulation of cell cycle G2/M phase transition|protein kinase complex NEK11 32.8461924098829 30.797046083305 34.8953387364607 1.13307421244459 0.180242355791692 0.739879296408693 1 0.0849556 0.0920265 0.136154 0.116447 GeneID:79858,Genbank:NM_001353038.1,HGNC:HGNC:18593,MIM:609779 NIMA related kinase 11 GO:0004674,GO:0005524,GO:0005654,GO:0005730,GO:0006468,GO:0016572,GO:0031573,GO:0035556,GO:0044772,GO:0046872,GO:1901990 protein serine/threonine kinase activity|ATP binding|nucleoplasm|nucleolus|protein phosphorylation|histone phosphorylation|intra-S DNA damage checkpoint|intracellular signal transduction|mitotic cell cycle phase transition|metal ion binding|regulation of mitotic cell cycle phase transition NEK2 694.622176286221 737.359908489377 651.884444083065 0.884079045494316 -0.177752728161594 0.376056629747757 1 8.9449 7.31369 8.34683 6.67983 GeneID:4751,Genbank:NM_001204182.1,HGNC:HGNC:7745,MIM:604043 NIMA related kinase 2 GO:0000070,GO:0000086,GO:0000278,GO:0000776,GO:0000777,GO:0000794,GO:0000922,GO:0001824,GO:0004672,GO:0004674,GO:0005524,GO:0005654,GO:0005730,GO:0005813,GO:0005829,GO:0005874,GO:0006468,GO:0007059,GO:0007088,GO:0010389,GO:0019903,GO:0030496,GO:0032212,GO:0043234,GO:0043392,GO:0046602,GO:0046777,GO:0046872,GO:0051225,GO:0051299,GO:0051301,GO:0051321,GO:0051973,GO:0051988,GO:0090307,GO:0097711,GO:1903126,GO:1904355 mitotic sister chromatid segregation|G2/M transition of mitotic cell cycle|mitotic cell cycle|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome|spindle pole|blastocyst development|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleoplasm|nucleolus|centrosome|cytosol|microtubule|protein phosphorylation|chromosome segregation|regulation of mitotic nuclear division|regulation of G2/M transition of mitotic cell cycle|protein phosphatase binding|midbody|positive regulation of telomere maintenance via telomerase|protein complex|negative regulation of DNA binding|regulation of mitotic centrosome separation|protein autophosphorylation|metal ion binding|spindle assembly|centrosome separation|cell division|meiotic cell cycle|positive regulation of telomerase activity|regulation of attachment of spindle microtubules to kinetochore|mitotic spindle assembly|ciliary basal body-plasma membrane docking|negative regulation of centriole-centriole cohesion|positive regulation of telomere capping NEK3 101.605438813584 113.060381026386 90.1504966007817 0.797365936523265 -0.32668612017495 0.266203190372972 1 1.23524 1.29169 1.26741 1.01303 GeneID:4752,Genbank:NM_002498.2,HGNC:HGNC:7746,MIM:604044 NIMA related kinase 3 GO:0000278,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0030010,GO:0030424,GO:0046872,GO:0048812,GO:0051301,GO:0090043 mitotic cell cycle|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|establishment of cell polarity|axon|metal ion binding|neuron projection morphogenesis|cell division|regulation of tubulin deacetylation NEK4 671.866892259532 739.848483118741 603.885301400323 0.816228342936811 -0.292955286883321 0.133739577085923 1 3.32086 2.57924 2.7302 2.17767 GeneID:6787,Genbank:NM_001193533.2,HGNC:HGNC:11399,MIM:601959 NIMA related kinase 4 GO:0000278,GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006974,GO:0007346,GO:0023014,GO:0030145,GO:0031098,GO:0032147,GO:0035253,GO:0035869,GO:0036064,GO:0042981,GO:0045893,GO:0051301,GO:0097014,GO:1900062,GO:2000772,GO:2001020 mitotic cell cycle|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|cellular response to DNA damage stimulus|regulation of mitotic cell cycle|signal transduction by protein phosphorylation|manganese ion binding|stress-activated protein kinase signaling cascade|activation of protein kinase activity|ciliary rootlet|ciliary transition zone|ciliary basal body|regulation of apoptotic process|positive regulation of transcription, DNA-templated|cell division|ciliary plasm|regulation of replicative cell aging|regulation of cellular senescence|regulation of response to DNA damage stimulus NEK5 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00841845 0 0 0.00753553 GeneID:341676,Genbank:NM_199289.2,HGNC:HGNC:7748,MIM:616731 NIMA related kinase 5 GO:0004674,GO:0005524,GO:0046872,GO:0051155,GO:2001056 protein serine/threonine kinase activity|ATP binding|metal ion binding|positive regulation of striated muscle cell differentiation|positive regulation of cysteine-type endopeptidase activity NEK6 1515.43348917967 1450.93191735033 1579.93506100901 1.08891054233218 0.122885436667348 0.411360248359113 1 12.5052 13.7222 15.2831 13.7431 GeneID:10783,Genbank:NM_001166167.1,HGNC:HGNC:7749,MIM:604884 NIMA related kinase 6 GO:0000287,GO:0000922,GO:0001222,GO:0004674,GO:0004871,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005874,GO:0006468,GO:0006915,GO:0007059,GO:0007077,GO:0007346,GO:0016607,GO:0018105,GO:0019894,GO:0019901,GO:0030071,GO:0031625,GO:0033613,GO:0043123,GO:0043231,GO:0043234,GO:0046777,GO:0051225,GO:0051301,GO:2000772 magnesium ion binding|spindle pole|transcription corepressor binding|protein serine/threonine kinase activity|signal transducer activity|ATP binding|nucleus|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|microtubule|protein phosphorylation|apoptotic process|chromosome segregation|mitotic nuclear envelope disassembly|regulation of mitotic cell cycle|nuclear speck|peptidyl-serine phosphorylation|kinesin binding|protein kinase binding|regulation of mitotic metaphase/anaphase transition|ubiquitin protein ligase binding|activating transcription factor binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle|protein complex|protein autophosphorylation|spindle assembly|cell division|regulation of cellular senescence NEK7 383.685211104073 427.112595435918 340.257826772228 0.796646669773236 -0.327988095629436 0.189322457465752 1 3.43559 3.15891 2.96479 2.13897 GeneID:140609,Genbank:NM_133494.2,HGNC:HGNC:13386,MIM:606848 NIMA related kinase 7 GO:0000922,GO:0004674,GO:0005524,GO:0005654,GO:0005737,GO:0005815,GO:0005874,GO:0006468,GO:0007346,GO:0032212,GO:0046872,GO:0051225,GO:0051973,GO:1904355 spindle pole|protein serine/threonine kinase activity|ATP binding|nucleoplasm|cytoplasm|microtubule organizing center|microtubule|protein phosphorylation|regulation of mitotic cell cycle|positive regulation of telomere maintenance via telomerase|metal ion binding|spindle assembly|positive regulation of telomerase activity|positive regulation of telomere capping hsa04621 NOD-like receptor signaling pathway NEK8 75.4366374513463 74.2977309979245 76.5755439047681 1.0306579067254 0.0435655565970461 0.979123124837103 1 0.532596 1.00093 0.897251 0.691229 GeneID:284086,Genbank:XM_011524638.3,HGNC:HGNC:13387,MIM:609799 NIMA related kinase 8 GO:0004674,GO:0005524,GO:0005737,GO:0005856,GO:0005929,GO:0007368,GO:0007507,GO:0009887,GO:0035330,GO:0046872,GO:0097543,GO:0097546 protein serine/threonine kinase activity|ATP binding|cytoplasm|cytoskeleton|cilium|determination of left/right symmetry|heart development|animal organ morphogenesis|regulation of hippo signaling|metal ion binding|ciliary inversin compartment|ciliary base NEK9 1052.59308791815 1032.6669821124 1072.5191937239 1.03859154238666 0.0546283822170486 0.720620218975126 1 5.42835 5.57808 6.29532 5.57876 GeneID:91754,Genbank:NM_001329238.1,HGNC:HGNC:18591,MIM:609798 NIMA related kinase 9 GO:0004674,GO:0005524,GO:0005634,GO:0005829,GO:0007077,GO:0019901,GO:0046872,GO:0051301 protein serine/threonine kinase activity|ATP binding|nucleus|cytosol|mitotic nuclear envelope disassembly|protein kinase binding|metal ion binding|cell division NELFA 791.934751927084 810.46780827614 773.401695578027 0.954265780430005 -0.0675369557992977 0.675633851151419 1 8.74122 8.83606 8.11921 9.09576 GeneID:7469,Genbank:NM_005663.4,HGNC:HGNC:12768,MIM:606026 negative elongation factor complex member A GO:0005654,GO:0005829,GO:0006355,GO:0006366,GO:0006368,GO:0007275,GO:0016604,GO:0032021,GO:0050434 nucleoplasm|cytosol|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|multicellular organism development|nuclear body|NELF complex|positive regulation of viral transcription NELFB 2476.97806656738 2360.71849008783 2593.23764304692 1.09849507848369 0.135528406162569 0.337136205776386 1 44.8881 44.8849 51.8712 49.7231 GeneID:25920,Genbank:NM_015456.4,HGNC:HGNC:24324,MIM:611180 negative elongation factor complex member B GO:0003723,GO:0005654,GO:0005737,GO:0006366,GO:0006368,GO:0032021,GO:0034244,GO:0050434 RNA binding|nucleoplasm|cytoplasm|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|NELF complex|negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of viral transcription NELFCD 3217.69049574331 3109.95679908462 3325.424192402 1.06928308244693 0.0966438433085149 0.488246832069229 1 50.1089 53.1407 55.9132 56.6065 GeneID:51497,Genbank:NM_198976.2,HGNC:HGNC:15934,MIM:605297 negative elongation factor complex member C/D GO:0003723,GO:0005654,GO:0006366,GO:0006368,GO:0016020,GO:0032021,GO:0045892,GO:0050434 RNA binding|nucleoplasm|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|membrane|NELF complex|negative regulation of transcription, DNA-templated|positive regulation of viral transcription NELFE 2817.17907792572 2850.36811987555 2783.99003597589 0.976712452178788 -0.0339942050329844 0.799251001608791 1 42.7816 45.0439 41.6508 46.359 GeneID:7936,Genbank:NM_002904.5,HGNC:HGNC:13974,MIM:154040 negative elongation factor complex member E GO:0003682,GO:0003723,GO:0005634,GO:0005654,GO:0005886,GO:0006366,GO:0006368,GO:0016604,GO:0032021,GO:0034244,GO:0045944,GO:0050434,GO:0051571,GO:0070374,GO:1900364 chromatin binding|RNA binding|nucleus|nucleoplasm|plasma membrane|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|nuclear body|NELF complex|negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|positive regulation of histone H3-K4 methylation|positive regulation of ERK1 and ERK2 cascade|negative regulation of mRNA polyadenylation NELL1 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0120548 0 0.0115472 GeneID:4745,Genbank:NM_001288713.1,HGNC:HGNC:7750,MIM:602319 neural EGFL like 1 GO:0005509,GO:0005576,GO:0005635,GO:0005737,GO:0007399,GO:0010468,GO:0030154,GO:0030501,GO:0033689,GO:0045669,GO:0048471,GO:1903363 calcium ion binding|extracellular region|nuclear envelope|cytoplasm|nervous system development|regulation of gene expression|cell differentiation|positive regulation of bone mineralization|negative regulation of osteoblast proliferation|positive regulation of osteoblast differentiation|perinuclear region of cytoplasm|negative regulation of cellular protein catabolic process NELL2 259.289083846136 252.045503080973 266.532664611298 1.05747835749194 0.0806281372378443 0.692529320014206 1 2.03084 1.87063 2.10176 2.34163 GeneID:4753,Genbank:NM_001145110.1,HGNC:HGNC:7751,MIM:602320 neural EGFL like 2 GO:0005509,GO:0005576,GO:0005623,GO:0070050 calcium ion binding|extracellular region|cell|neuron cellular homeostasis NEMF 110.830840693915 113.098598645963 108.563082741866 0.95989768256727 -0.0590474606365811 0.860286679075677 1 0.394693 0.390808 0.460558 0.360023 GeneID:9147,Genbank:XM_017021760.2,HGNC:HGNC:10663,MIM:608378 nuclear export mediator factor GO:0005634,GO:0051168 nucleus|nuclear export NEMP1 1346.48831319806 1348.48636003017 1344.49026636596 0.99703660802018 -0.00428161810784899 0.999890204622114 1 8.95662 8.12915 9.90199 7.59327 GeneID:23306,Genbank:XM_011538056.2,HGNC:HGNC:29001,MIM:616496 nuclear envelope integral membrane protein 1 GO:0005635,GO:0005637,GO:0016021 nuclear envelope|nuclear inner membrane|integral component of membrane NEMP2 227.457173328794 227.609576568006 227.304770089582 0.998660836318841 -0.00193329959316529 0.998097718740178 1 1.4099 1.18594 1.49984 1.13043 GeneID:100131211,Genbank:XM_017003100.1,HGNC:HGNC:33700,MIM:616497 nuclear envelope integral membrane protein 2 GO:0005635,GO:0005637,GO:0016021 nuclear envelope|nuclear inner membrane|integral component of membrane NENF 1038.16860485143 928.869931448518 1147.46727825433 1.23533687484633 0.304904516625599 0.172442262018467 1 38.4984 37.7135 42.8738 52.4891 GeneID:29937,Genbank:NM_013349.4,HGNC:HGNC:30384,MIM:611874 neudesin neurotrophic factor GO:0005615,GO:0005634,GO:0005654,GO:0008083,GO:0012505,GO:0016020,GO:0032099,GO:0043410,GO:0046872 extracellular space|nucleus|nucleoplasm|growth factor activity|endomembrane system|membrane|negative regulation of appetite|positive regulation of MAPK cascade|metal ion binding NEO1 1153.85482767186 1062.12808415878 1245.58157118495 1.17272256497338 0.229861750384252 0.122739179307361 1 5.01227 4.78917 6.51749 5.2057 GeneID:4756,Genbank:XM_005254408.1,HGNC:HGNC:7754,MIM:601907 neogenin 1 GO:0004872,GO:0005654,GO:0005794,GO:0005886,GO:0005887,GO:0007155,GO:0007411,GO:0030513,GO:0039706,GO:0055072,GO:0098797 receptor activity|nucleoplasm|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell adhesion|axon guidance|positive regulation of BMP signaling pathway|co-receptor binding|iron ion homeostasis|plasma membrane protein complex hsa04514 Cell adhesion molecules (CAMs) NEPRO 329.782101778473 362.972093710151 296.592109846795 0.817120971519195 -0.29137841542543 0.144877171921408 1 2.87451 2.43559 2.35515 2.12392 GeneID:25871,Genbank:NM_001319110.1,HGNC:HGNC:24496,MIM:617089 nucleolus and neural progenitor protein GO:0005634,GO:0005730,GO:0045665,GO:0045747 nucleus|nucleolus|negative regulation of neuron differentiation|positive regulation of Notch signaling pathway NES 12341.65517943 11318.7461037673 13364.5642550926 1.18074600601248 0.239698655441274 0.0636134618653146 0.897898872552551 59.7043 59.2005 69.3554 72.3987 GeneID:10763,Genbank:NM_006617.1,HGNC:HGNC:7756,MIM:600915 nestin GO:0000086,GO:0005198,GO:0005737,GO:0005882,GO:0007417,GO:0007420,GO:0019215,GO:0030844,GO:0031012,GO:0031076,GO:0032091,GO:0043086,GO:0045111,GO:0072089,GO:2000179 G2/M transition of mitotic cell cycle|structural molecule activity|cytoplasm|intermediate filament|central nervous system development|brain development|intermediate filament binding|positive regulation of intermediate filament depolymerization|extracellular matrix|embryonic camera-type eye development|negative regulation of protein binding|negative regulation of catalytic activity|intermediate filament cytoskeleton|stem cell proliferation|positive regulation of neural precursor cell proliferation NET1 2448.7851402285 2844.11758516052 2053.45269529648 0.721999929261217 -0.469929399124634 0.000744620546313075 0.0828183518732653 15.0076 14.4176 11.291 9.99418 GeneID:10276,Genbank:NM_001047160.2,HGNC:HGNC:14592,MIM:606450 neuroepithelial cell transforming 1 NETO2 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0 0 0.0235109 0.0108887 GeneID:81831,Genbank:NM_001201477.1,HGNC:HGNC:14644,MIM:607974 neuropilin and tolloid like 2 GO:0014069,GO:0016021,GO:0035255,GO:2000312 postsynaptic density|integral component of membrane|ionotropic glutamate receptor binding|regulation of kainate selective glutamate receptor activity NEU1 4673.81286145424 4325.18704040624 5022.43868250225 1.1612072808834 0.215625522944801 0.109233838649034 1 88.1232 91.3715 102.404 108.51 GeneID:4758,Genbank:NM_000434.3,HGNC:HGNC:7758,MIM:608272 neuraminidase 1 hsa00511,hsa00600,hsa04142 Other glycan degradation|Sphingolipid metabolism|Lysosome NEU2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0389138 0 0 GeneID:4759,Genbank:NM_005383.2,HGNC:HGNC:7759,MIM:605528 neuraminidase 2 GO:0004308,GO:0005737,GO:0005829,GO:0006687,GO:0006689,GO:0009313,GO:0016020,GO:0043231,GO:0051692,GO:0052794,GO:0052795,GO:0052796,GO:1902494 exo-alpha-sialidase activity|cytoplasm|cytosol|glycosphingolipid metabolic process|ganglioside catabolic process|oligosaccharide catabolic process|membrane|intracellular membrane-bounded organelle|cellular oligosaccharide catabolic process|exo-alpha-(2->3)-sialidase activity|exo-alpha-(2->6)-sialidase activity|exo-alpha-(2->8)-sialidase activity|catalytic complex hsa00511,hsa00600 Other glycan degradation|Sphingolipid metabolism NEU3 171.398622937572 178.027138076905 164.77010779824 0.925533655026582 -0.11164264335752 0.652595940368451 1 2.43903 2.35546 2.18038 2.23427 GeneID:10825,Genbank:NM_006656.5,HGNC:HGNC:7760,MIM:604617 neuraminidase 3 hsa00511,hsa00600 Other glycan degradation|Sphingolipid metabolism NEU4 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0453759 0 GeneID:129807,Genbank:NM_001167601.2,HGNC:HGNC:21328,MIM:608527 neuraminidase 4 GO:0004308,GO:0005739,GO:0005764,GO:0006516,GO:0006687,GO:0006689,GO:0009313,GO:0019866,GO:0043202,GO:0052794,GO:0052795,GO:0052796 exo-alpha-sialidase activity|mitochondrion|lysosome|glycoprotein catabolic process|glycosphingolipid metabolic process|ganglioside catabolic process|oligosaccharide catabolic process|organelle inner membrane|lysosomal lumen|exo-alpha-(2->3)-sialidase activity|exo-alpha-(2->6)-sialidase activity|exo-alpha-(2->8)-sialidase activity hsa00511,hsa00600 Other glycan degradation|Sphingolipid metabolism NEURL1 4.18394121465297 3.03648096111406 5.33140146819188 1.75578293968155 0.812114501364697 0.651910877643087 1 0.00729643 0.0257024 0.0340597 0.0318229 GeneID:9148,Genbank:XM_011540331.3,HGNC:HGNC:7761,MIM:603804 neuralized E3 ubiquitin protein ligase 1 GO:0004842,GO:0005886,GO:0006513,GO:0007219,GO:0007288,GO:0007399,GO:0007420,GO:0007519,GO:0007595,GO:0008285,GO:0014069,GO:0030054,GO:0043065,GO:0043197,GO:0043204,GO:0045183,GO:0045211,GO:0045741,GO:0045746,GO:0046872,GO:0048170,GO:0048471,GO:0051491,GO:0060999,GO:0061630,GO:0071230,GO:0090129,GO:0097440 ubiquitin-protein transferase activity|plasma membrane|protein monoubiquitination|Notch signaling pathway|sperm axoneme assembly|nervous system development|brain development|skeletal muscle tissue development|lactation|negative regulation of cell proliferation|postsynaptic density|cell junction|positive regulation of apoptotic process|dendritic spine|perikaryon|translation factor activity, non-nucleic acid binding|postsynaptic membrane|positive regulation of epidermal growth factor-activated receptor activity|negative regulation of Notch signaling pathway|metal ion binding|positive regulation of long-term neuronal synaptic plasticity|perinuclear region of cytoplasm|positive regulation of filopodium assembly|positive regulation of dendritic spine development|ubiquitin protein ligase activity|cellular response to amino acid stimulus|positive regulation of synapse maturation|apical dendrite NEURL1B 856.050109723946 696.801685988211 1015.29853345968 1.4570839219767 0.543083973032396 0.000555888269982733 0.0663583556644534 4.90812 5.02458 7.58501 7.15883 GeneID:54492,Genbank:NM_001142651.2,HGNC:HGNC:35422,MIM:615893 neuralized E3 ubiquitin protein ligase 1B GO:0005769,GO:0007219,GO:0016567,GO:0016740,GO:0016874,GO:0046872,GO:0070086 early endosome|Notch signaling pathway|protein ubiquitination|transferase activity|ligase activity|metal ion binding|ubiquitin-dependent endocytosis NEURL2 10.2347158092668 11.2618335899114 9.20759802862226 0.817593152581356 -0.290544981266291 0.7916185732963 1 0.625758 0.844187 0.905287 1.11186 GeneID:140825,Genbank:NM_080749.3,HGNC:HGNC:16156,MIM:608597 neuralized E3 ubiquitin protein ligase 2 GO:0005829,GO:0016567,GO:0035556,GO:0043687 cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification NEURL3 3.45927529648401 3.52655236307142 3.3919982298966 0.96184541747237 -0.056123044307815 1 1 0.0502566 0.0221226 0.0468552 0.087107 GeneID:93082,Genbank:XM_011512179.2,HGNC:HGNC:25162,MIM:617206 neuralized E3 ubiquitin protein ligase 3 GO:0046872,GO:0061630 metal ion binding|ubiquitin protein ligase activity NEURL4 1006.50136927766 998.710010554996 1014.29272800032 1.01560284495062 0.0223363414434687 0.914444096153878 1 6.15808 6.65801 6.63262 6.9079 GeneID:84461,Genbank:NM_001005408.1,HGNC:HGNC:34410,MIM:615865 neuralized E3 ubiquitin protein ligase 4 GO:0005814 centriole NEUROD2 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0537848 0 GeneID:4761,Genbank:NM_006160.3,HGNC:HGNC:7763,MIM:601725 neuronal differentiation 2 GO:0001228,GO:0001662,GO:0003700,GO:0003714,GO:0005634,GO:0006357,GO:0007399,GO:0008306,GO:0016567,GO:0021695,GO:0031915,GO:0045666,GO:0046982,GO:0048666,GO:0050850,GO:0051091,GO:0070888,GO:0071257,GO:0071277,GO:0090129,GO:2000297 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|behavioral fear response|DNA binding transcription factor activity|transcription corepressor activity|nucleus|regulation of transcription from RNA polymerase II promoter|nervous system development|associative learning|protein ubiquitination|cerebellar cortex development|positive regulation of synaptic plasticity|positive regulation of neuron differentiation|protein heterodimerization activity|neuron development|positive regulation of calcium-mediated signaling|positive regulation of DNA binding transcription factor activity|E-box binding|cellular response to electrical stimulus|cellular response to calcium ion|positive regulation of synapse maturation|negative regulation of synapse maturation NEUROG2 16.07313215373 10.819788462639 21.3264758448209 1.97106218097164 0.978973289706816 0.173051017324413 1 0.26928 0.190745 0.525605 0.350585 GeneID:63973,Genbank:NM_024019.3,HGNC:HGNC:13805,MIM:606624 neurogenin 2 GO:0005634,GO:0006351,GO:0030182,GO:0046983,GO:0051091,GO:0070888 nucleus|transcription, DNA-templated|neuron differentiation|protein dimerization activity|positive regulation of DNA binding transcription factor activity|E-box binding NEXN 144.658327768893 141.963768085908 147.352887451878 1.03796123080298 0.0537525581728362 0.876928827507154 1 0.559715 0.394202 0.623887 0.406971 GeneID:91624,Genbank:NM_144573.3,HGNC:HGNC:29557,MIM:613121 nexilin F-actin binding protein GO:0005856,GO:0005925,GO:0008307,GO:0030018,GO:0030334,GO:0048739,GO:0051015,GO:0051493 cytoskeleton|focal adhesion|structural constituent of muscle|Z disc|regulation of cell migration|cardiac muscle fiber development|actin filament binding|regulation of cytoskeleton organization NF1 267.960972195743 273.195008604294 262.726935787193 0.961682781575768 -0.0563670064209503 0.887166420491258 1 0.794529 0.739236 0.934117 0.557711 GeneID:4763,Genbank:NM_001042492.2,HGNC:HGNC:7765,MIM:613113 neurofibromin 1 hsa01521,hsa04010,hsa04014 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway NF2 6788.24854700288 7425.92650140133 6150.57059260442 0.828256324842934 -0.271850779636074 0.037728347149262 0.744558420459959 40.6261 41.3004 36.099 32.8401 GeneID:4771,Genbank:NM_181832.2,HGNC:HGNC:7773,MIM:607379 neurofibromin 2 GO:0001707,GO:0001726,GO:0003779,GO:0005178,GO:0005634,GO:0005730,GO:0005737,GO:0005769,GO:0005856,GO:0005886,GO:0005912,GO:0006469,GO:0007398,GO:0007420,GO:0008013,GO:0008156,GO:0008285,GO:0014010,GO:0014013,GO:0016020,GO:0019904,GO:0021766,GO:0022408,GO:0030027,GO:0030036,GO:0030175,GO:0030308,GO:0030864,GO:0031647,GO:0032154,GO:0035330,GO:0042127,GO:0042475,GO:0042532,GO:0042981,GO:0043005,GO:0043234,GO:0043409,GO:0044297,GO:0045121,GO:0045177,GO:0045202,GO:0045216,GO:0045597,GO:0046426,GO:0048471,GO:0050767,GO:0051496,GO:0051726,GO:0070306,GO:0072091,GO:1900180,GO:2000177 mesoderm formation|ruffle|actin binding|integrin binding|nucleus|nucleolus|cytoplasm|early endosome|cytoskeleton|plasma membrane|adherens junction|negative regulation of protein kinase activity|ectoderm development|brain development|beta-catenin binding|negative regulation of DNA replication|negative regulation of cell proliferation|Schwann cell proliferation|regulation of gliogenesis|membrane|protein domain specific binding|hippocampus development|negative regulation of cell-cell adhesion|lamellipodium|actin cytoskeleton organization|filopodium|negative regulation of cell growth|cortical actin cytoskeleton|regulation of protein stability|cleavage furrow|regulation of hippo signaling|regulation of cell proliferation|odontogenesis of dentin-containing tooth|negative regulation of tyrosine phosphorylation of STAT protein|regulation of apoptotic process|neuron projection|protein complex|negative regulation of MAPK cascade|cell body|membrane raft|apical part of cell|synapse|cell-cell junction organization|positive regulation of cell differentiation|negative regulation of JAK-STAT cascade|perinuclear region of cytoplasm|regulation of neurogenesis|positive regulation of stress fiber assembly|regulation of cell cycle|lens fiber cell differentiation|regulation of stem cell proliferation|regulation of protein localization to nucleus|regulation of neural precursor cell proliferation hsa04390,hsa04392,hsa04530 Hippo signaling pathway|Hippo signaling pathway - multiple species|Tight junction NFAM1 4.67781912437553 4.50669516698614 4.84894308176491 1.0759421043797 0.105600449668255 1 1 0.013653 0.0359326 0.038053 0.0118855 GeneID:150372,Genbank:XM_005261374.4,HGNC:HGNC:29872,MIM:608740 NFAT activating protein with ITAM motif 1 GO:0001819,GO:0004888,GO:0005886,GO:0006954,GO:0007165,GO:0007166,GO:0016021,GO:0030183,GO:0035556,GO:0035577,GO:0043312,GO:0045577,GO:0050861,GO:0051091 positive regulation of cytokine production|transmembrane signaling receptor activity|plasma membrane|inflammatory response|signal transduction|cell surface receptor signaling pathway|integral component of membrane|B cell differentiation|intracellular signal transduction|azurophil granule membrane|neutrophil degranulation|regulation of B cell differentiation|positive regulation of B cell receptor signaling pathway|positive regulation of DNA binding transcription factor activity NFASC 28.027135536884 31.8252151619047 24.2290559118634 0.76131632696284 -0.393432076745977 0.478254054600397 1 0.0749859 0.0669774 0.040967 0.0629856 GeneID:23114,Genbank:XM_011509318.2,HGNC:HGNC:29866,MIM:609145 neurofascin GO:0002175,GO:0005622,GO:0005886,GO:0005925,GO:0007411,GO:0007422,GO:0016021,GO:0019226,GO:0019904,GO:0030425,GO:0030913,GO:0033010,GO:0033268,GO:0033270,GO:0042552,GO:0043194,GO:0043209,GO:0043312,GO:0045162,GO:0050808,GO:0070062,GO:0071205,GO:0072659,GO:0086080,GO:0097454,GO:0101003 protein localization to paranode region of axon|intracellular|plasma membrane|focal adhesion|axon guidance|peripheral nervous system development|integral component of membrane|transmission of nerve impulse|protein domain specific binding|dendrite|paranodal junction assembly|paranodal junction|node of Ranvier|paranode region of axon|myelination|axon initial segment|myelin sheath|neutrophil degranulation|clustering of voltage-gated sodium channels|synapse organization|extracellular exosome|protein localization to juxtaparanode region of axon|protein localization to plasma membrane|protein binding involved in heterotypic cell-cell adhesion|Schwann cell microvillus|ficolin-1-rich granule membrane hsa04514 Cell adhesion molecules (CAMs) NFAT5 417.254934618059 375.896246604675 458.613622631444 1.22005374295147 0.286944699412639 0.629745020420743 1 1.1226 0.94462 1.78875 0.762634 GeneID:10725,Genbank:XM_011522819.3,HGNC:HGNC:7774,MIM:604708 nuclear factor of activated T cells 5 GO:0000978,GO:0001077,GO:0001816,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006366,GO:0007165,GO:0007588,GO:0045944,GO:0070884 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|cytokine production|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|transcription from RNA polymerase II promoter|signal transduction|excretion|positive regulation of transcription from RNA polymerase II promoter|regulation of calcineurin-NFAT signaling cascade NFATC1 87.5031328494701 81.9653686398637 93.0408970590765 1.13512448736583 0.18285052435046 0.576626101713618 1 0.633398 0.63476 0.702469 0.832342 GeneID:4772,Genbank:NM_001278669.1,HGNC:HGNC:7775,MIM:600489 nuclear factor of activated T cells 1 GO:0000790,GO:0000980,GO:0001085,GO:0001205,GO:0001225,GO:0003700,GO:0003705,GO:0005528,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006366,GO:0007223,GO:0016604,GO:0030178,GO:0033173,GO:0035556,GO:0038095,GO:0045893,GO:0045944,GO:0048273 nuclear chromatin|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II transcription coactivator binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|FK506 binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription from RNA polymerase II promoter|Wnt signaling pathway, calcium modulating pathway|nuclear body|negative regulation of Wnt signaling pathway|calcineurin-NFAT signaling cascade|intracellular signal transduction|Fc-epsilon receptor signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|mitogen-activated protein kinase p38 binding hsa04010,hsa04022,hsa04024,hsa04218,hsa04310,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04921,hsa04933,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170,hsa05321 MAPK signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Cellular senescence|Wnt signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Oxytocin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Inflammatory bowel disease (IBD) NFATC2 6.69165495790822 5.6309167949557 7.75239312086075 1.37675504774028 0.461271898001421 0.74049615602988 1 0.0220217 0.0202237 0.0249955 0.0350296 GeneID:4773,Genbank:NM_001258295.1,HGNC:HGNC:7776,MIM:600490 nuclear factor of activated T cells 2 hsa04022,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04921,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170 cGMP-PKG signaling pathway|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Oxytocin signaling pathway|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection NFATC2IP 1239.548269758 1206.85100121365 1272.24553830234 1.05418609009971 0.0761295610611586 0.616301464894811 1 11.9249 12.3505 14.204 11.5786 GeneID:84901,Genbank:NM_032815.3,HGNC:HGNC:25906,MIM:614525 nuclear factor of activated T cells 2 interacting protein GO:0001816,GO:0005634,GO:0005737,GO:0016925,GO:0031386,GO:0045944 cytokine production|nucleus|cytoplasm|protein sumoylation|protein tag|positive regulation of transcription from RNA polymerase II promoter NFATC3 969.022621533619 1014.25497424612 923.790268821118 0.910806742168315 -0.13478312394775 0.410322834096192 1 6.51284 5.96371 6.43655 5.02105 GeneID:4775,Genbank:NM_004555.3,HGNC:HGNC:7777,MIM:602698 nuclear factor of activated T cells 3 GO:0000978,GO:0001077,GO:0001227,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006357,GO:0006366,GO:0006954,GO:0038095,GO:0045944,GO:1902894 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|inflammatory response|Fc-epsilon receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|negative regulation of pri-miRNA transcription from RNA polymerase II promoter hsa04010,hsa04022,hsa04218,hsa04310,hsa04360,hsa04625,hsa04658,hsa04659,hsa04660,hsa04662,hsa04921,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170 MAPK signaling pathway|cGMP-PKG signaling pathway|Cellular senescence|Wnt signaling pathway|Axon guidance|C-type lectin receptor signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Oxytocin signaling pathway|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection NFATC4 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.0126677 0 0 GeneID:4776,Genbank:NM_001136022.2,HGNC:HGNC:7778,MIM:602699 nuclear factor of activated T cells 4 GO:0000978,GO:0001078,GO:0001227,GO:0001569,GO:0003713,GO:0005634,GO:0005667,GO:0005829,GO:0006366,GO:0006954,GO:0007507,GO:0008134,GO:0008630,GO:0016607,GO:0030178,GO:0032091,GO:0032760,GO:0033173,GO:0034644,GO:0035562,GO:0042975,GO:0045333,GO:0045944,GO:0048167,GO:0050774,GO:0051145,GO:0055001,GO:0071285,GO:1902894,GO:1904637,GO:2000297,GO:2001235 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|branching involved in blood vessel morphogenesis|transcription coactivator activity|nucleus|transcription factor complex|cytosol|transcription from RNA polymerase II promoter|inflammatory response|heart development|transcription factor binding|intrinsic apoptotic signaling pathway in response to DNA damage|nuclear speck|negative regulation of Wnt signaling pathway|negative regulation of protein binding|positive regulation of tumor necrosis factor production|calcineurin-NFAT signaling cascade|cellular response to UV|negative regulation of chromatin binding|peroxisome proliferator activated receptor binding|cellular respiration|positive regulation of transcription from RNA polymerase II promoter|regulation of synaptic plasticity|negative regulation of dendrite morphogenesis|smooth muscle cell differentiation|muscle cell development|cellular response to lithium ion|negative regulation of pri-miRNA transcription from RNA polymerase II promoter|cellular response to ionomycin|negative regulation of synapse maturation|positive regulation of apoptotic signaling pathway hsa04022,hsa04218,hsa04310,hsa04360,hsa04625,hsa04921,hsa05161,hsa05163,hsa05166,hsa05167,hsa05170 cGMP-PKG signaling pathway|Cellular senescence|Wnt signaling pathway|Axon guidance|C-type lectin receptor signaling pathway|Oxytocin signaling pathway|Hepatitis B|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection NFE2 5.92504297476923 7.48534119830732 4.36474475123113 0.583105650844366 -0.778170790981312 0.763873746020309 1 0.225795 0.0155984 0.129924 0.0151722 GeneID:4778,Genbank:NM_001136023.2,HGNC:HGNC:7780,MIM:601490 nuclear factor, erythroid 2 NFE2L1 10779.0129896261 9316.89618408295 12241.1297951693 1.31386349630922 0.39381539481734 0.00258003407241552 0.184112172734141 63.0331 64.7881 86.2598 83.8622 GeneID:4779,Genbank:NM_001330262.1,HGNC:HGNC:7781,MIM:163260 nuclear factor, erythroid 2 like 1 GO:0000122,GO:0000976,GO:0000978,GO:0000980,GO:0001077,GO:0001078,GO:0001190,GO:0001205,GO:0003700,GO:0003712,GO:0005634,GO:0005737,GO:0005789,GO:0005829,GO:0006357,GO:0006366,GO:0006783,GO:0006954,GO:0008203,GO:0008289,GO:0009653,GO:0015485,GO:0016021,GO:0019904,GO:0030176,GO:0030218,GO:0032403,GO:0034599,GO:0036003,GO:0043234,GO:0045454,GO:0045893,GO:0046982,GO:0055088,GO:0071397,GO:0097201,GO:1901329,GO:2000188 negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|DNA binding transcription factor activity|transcription cofactor activity|nucleus|cytoplasm|endoplasmic reticulum membrane|cytosol|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|heme biosynthetic process|inflammatory response|cholesterol metabolic process|lipid binding|anatomical structure morphogenesis|cholesterol binding|integral component of membrane|protein domain specific binding|integral component of endoplasmic reticulum membrane|erythrocyte differentiation|protein complex binding|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|protein complex|cell redox homeostasis|positive regulation of transcription, DNA-templated|protein heterodimerization activity|lipid homeostasis|cellular response to cholesterol|negative regulation of transcription from RNA polymerase II promoter in response to stress|regulation of odontoblast differentiation|regulation of cholesterol homeostasis NFE2L2 723.349278374392 736.658114678464 710.040442070321 0.963866993279833 -0.0530940162480727 0.837168083466461 1 9.20855 7.14857 9.00731 7.26277 GeneID:4780,Genbank:NM_001313903.1,HGNC:HGNC:7782,MIM:600492 nuclear factor, erythroid 2 like 2 GO:0000785,GO:0000976,GO:0000980,GO:0001102,GO:0001205,GO:0001221,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005886,GO:0006366,GO:0006954,GO:0007568,GO:0010499,GO:0010628,GO:0010667,GO:0010976,GO:0016567,GO:0019904,GO:0030194,GO:0030968,GO:0032993,GO:0034599,GO:0036003,GO:0036091,GO:0036499,GO:0042149,GO:0043161,GO:0043536,GO:0044212,GO:0045454,GO:0045766,GO:0045944,GO:0045995,GO:0046223,GO:0046326,GO:0070301,GO:0071356,GO:0071456,GO:0071498,GO:0071499,GO:1902037,GO:1902176,GO:1903071,GO:1903206,GO:1903788,GO:1904385,GO:1904753,GO:2000121,GO:2000352,GO:2000379 chromatin|transcription regulatory region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|transcription cofactor binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cytosol|plasma membrane|transcription from RNA polymerase II promoter|inflammatory response|aging|proteasomal ubiquitin-independent protein catabolic process|positive regulation of gene expression|negative regulation of cardiac muscle cell apoptotic process|positive regulation of neuron projection development|protein ubiquitination|protein domain specific binding|positive regulation of blood coagulation|endoplasmic reticulum unfolded protein response|protein-DNA complex|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|PERK-mediated unfolded protein response|cellular response to glucose starvation|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of blood vessel endothelial cell migration|transcription regulatory region DNA binding|cell redox homeostasis|positive regulation of angiogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of embryonic development|aflatoxin catabolic process|positive regulation of glucose import|cellular response to hydrogen peroxide|cellular response to tumor necrosis factor|cellular response to hypoxia|cellular response to fluid shear stress|cellular response to laminar fluid shear stress|negative regulation of hematopoietic stem cell differentiation|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of hydrogen peroxide-induced cell death|positive regulation of glutathione biosynthetic process|cellular response to angiotensin|negative regulation of vascular associated smooth muscle cell migration|regulation of removal of superoxide radicals|negative regulation of endothelial cell apoptotic process|positive regulation of reactive oxygen species metabolic process hsa04141,hsa05200,hsa05225,hsa05418 Protein processing in endoplasmic reticulum|Pathways in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis NFE2L3 1378.54197473662 1572.07153817974 1185.01241129351 0.753790385815137 -0.407764700555401 0.00537129981437456 0.285941071095182 15.9116 16.0794 13.5091 10.7847 GeneID:9603,Genbank:NM_004289.6,HGNC:HGNC:7783,MIM:604135 nuclear factor, erythroid 2 like 3 GO:0000976,GO:0000978,GO:0001078,GO:0003700,GO:0003713,GO:0005634,GO:0005737,GO:0006357,GO:0006366,GO:0045893 transcription regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|transcription coactivator activity|nucleus|cytoplasm|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-templated NFE4 1.21386734807293 0.490071401957362 1.93766329418849 3.95383873951713 1.98325403079315 0.683591311517638 1 0 0 0 0.0408266 GeneID:58160,Genbank:NM_001085386.1,HGNC:HGNC:29902,MIM:612133 nuclear factor, erythroid 4 GO:0000987,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0006357,GO:0006461,GO:0042803,GO:0043234,GO:0045944 proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein homodimerization activity|protein complex|positive regulation of transcription from RNA polymerase II promoter NFIA 68.005893284984 59.4318928049329 76.5798937650351 1.28853196744693 0.365728329750932 0.289561911839656 1 0.257528 0.213502 0.352136 0.217454 GeneID:4774,Genbank:XM_011541514.3,HGNC:HGNC:7784,MIM:600727 nuclear factor I A GO:0000122,GO:0000978,GO:0001077,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0006260,GO:0006355,GO:0008134,GO:0019079,GO:0030054,GO:0045944,GO:0060074,GO:0072189 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|chromatin binding|DNA binding transcription factor activity|nucleus|nucleoplasm|DNA replication|regulation of transcription, DNA-templated|transcription factor binding|viral genome replication|cell junction|positive regulation of transcription from RNA polymerase II promoter|synapse maturation|ureter development NFIB 801.940926002294 840.95504539941 762.926806605177 0.907214732557822 -0.140484026018675 0.626135952173988 1 2.37854 2.03012 2.50236 1.64828 GeneID:4781,Genbank:NM_001190738.1,HGNC:HGNC:7785,MIM:600728 nuclear factor I B GO:0000122,GO:0000978,GO:0000981,GO:0001077,GO:0001106,GO:0001650,GO:0002062,GO:0003677,GO:0005634,GO:0006260,GO:0008285,GO:0010001,GO:0021740,GO:0021960,GO:0030324,GO:0030900,GO:0030902,GO:0043392,GO:0044300,GO:0045944,GO:0060486,GO:0060509,GO:0060510,GO:0060662,GO:0060689,GO:0061141,GO:0071679,GO:1902894,GO:2000791,GO:2000795 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription corepressor activity|fibrillar center|chondrocyte differentiation|DNA binding|nucleus|DNA replication|negative regulation of cell proliferation|glial cell differentiation|principal sensory nucleus of trigeminal nerve development|anterior commissure morphogenesis|lung development|forebrain development|hindbrain development|negative regulation of DNA binding|cerebellar mossy fiber|positive regulation of transcription from RNA polymerase II promoter|Clara cell differentiation|Type I pneumocyte differentiation|Type II pneumocyte differentiation|salivary gland cavitation|cell differentiation involved in salivary gland development|lung ciliated cell differentiation|commissural neuron axon guidance|negative regulation of pri-miRNA transcription from RNA polymerase II promoter|negative regulation of mesenchymal cell proliferation involved in lung development|negative regulation of epithelial cell proliferation involved in lung morphogenesis NFIC 6089.94350141413 5745.30127736219 6434.58572546608 1.11997359491309 0.163464718946265 0.220457097883084 1 23.9082 24.0053 28.5559 25.8572 GeneID:4782,Genbank:NM_205843.2,HGNC:HGNC:7786,MIM:600729 nuclear factor I C GO:0000122,GO:0000978,GO:0001077,GO:0001650,GO:0003700,GO:0005634,GO:0006260,GO:0006366,GO:0042475,GO:0045944 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|fibrillar center|DNA binding transcription factor activity|nucleus|DNA replication|transcription from RNA polymerase II promoter|odontogenesis of dentin-containing tooth|positive regulation of transcription from RNA polymerase II promoter NFIL3 181.393473939734 202.85708344246 159.929864437009 0.788386886585466 -0.343024314974071 0.144403560616114 1 2.63867 2.9416 2.30306 2.11664 GeneID:4783,Genbank:XM_017014743.1,HGNC:HGNC:7787,MIM:605327 nuclear factor, interleukin 3 regulated GO:0000122,GO:0000977,GO:0000978,GO:0001078,GO:0003677,GO:0003700,GO:0003714,GO:0005634,GO:0006366,GO:0006955,GO:0007623,GO:0010628,GO:0071353 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|transcription from RNA polymerase II promoter|immune response|circadian rhythm|positive regulation of gene expression|cellular response to interleukin-4 NFIX 7299.16134667825 6338.03533834691 8260.28735500959 1.30328830844986 0.382156266685027 0.00368877983569464 0.233428946488645 37.4607 36.8192 48.7127 49.4254 GeneID:4784,Genbank:XM_017026837.1,HGNC:HGNC:7788,MIM:164005 nuclear factor I X GO:0000122,GO:0003677,GO:0003700,GO:0003705,GO:0005634,GO:0006260,GO:0006366,GO:0045944 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|DNA replication|transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter NFKB1 826.144719122941 787.193304009865 865.096134236017 1.09896277042668 0.13614251291993 0.380125552504058 1 6.35491 5.82277 7.14909 6.31261 GeneID:4790,Genbank:XM_024454069.1,HGNC:HGNC:7794,MIM:164011 nuclear factor kappa B subunit 1 hsa01523,hsa04010,hsa04014,hsa04024,hsa04062,hsa04064,hsa04066,hsa04071,hsa04151,hsa04210,hsa04211,hsa04218,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04917,hsa04920,hsa04926,hsa04931,hsa04932,hsa04933,hsa05030,hsa05120,hsa05131,hsa05132,hsa05133,hsa05134,hsa05140,hsa05142,hsa05145,hsa05146,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05202,hsa05203,hsa05206,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05321,hsa05418 Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Cellular senescence|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Cocaine addiction|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|MicroRNAs in cancer|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Inflammatory bowel disease (IBD)|Fluid shear stress and atherosclerosis NFKB2 1246.23376890887 1469.49577869406 1022.97175912368 0.69613793653276 -0.522554897096455 0.000405185847951571 0.0555498145806552 8.59315 9.26103 5.84681 6.65793 GeneID:4791,Genbank:NM_001288724.1,HGNC:HGNC:7795,MIM:164012 nuclear factor kappa B subunit 2 hsa04010,hsa04064,hsa04380,hsa04625,hsa05134,hsa05166,hsa05169,hsa05200,hsa05203,hsa05224 MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Legionellosis|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Breast cancer NFKBIA 915.786423615995 1022.28044712278 809.292400109211 0.791653995131154 -0.337058079455784 0.0280198886038037 0.668561867500627 24.3658 26.1147 19.6706 20.6488 GeneID:4792,Genbank:NM_020529.2,HGNC:HGNC:7797,MIM:164008 NFKB inhibitor alpha hsa04024,hsa04062,hsa04064,hsa04210,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04920,hsa04926,hsa04931,hsa05120,hsa05131,hsa05134,hsa05140,hsa05142,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05215,hsa05220,hsa05222 cAMP signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|Apoptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Insulin resistance|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Legionellosis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Prostate cancer|Chronic myeloid leukemia|Small cell lung cancer NFKBIB 588.594422240545 563.63958582732 613.54925865377 1.08854891331522 0.122406235649075 0.484931067933584 1 12.7981 13.4937 15.8012 14.2779 GeneID:4793,Genbank:XM_006723227.3,HGNC:HGNC:7798,MIM:604495 NFKB inhibitor beta hsa04062,hsa04621,hsa04622,hsa04623,hsa04658,hsa04659,hsa04660,hsa04662,hsa04722,hsa04920,hsa05131,hsa05140,hsa05145,hsa05162,hsa05164,hsa05168,hsa05169 Chemokine signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Shigellosis|Leishmaniasis|Toxoplasmosis|Measles|Influenza A|Herpes simplex infection|Epstein-Barr virus infection NFKBID 80.0749832764603 85.0400672205547 75.1098993323658 0.883229538584034 -0.179139672707778 0.6116470709801 1 0.660644 0.430169 0.421935 0.515555 GeneID:84807,Genbank:XM_017027390.1,HGNC:HGNC:15671 NFKB inhibitor delta GO:0003712,GO:0005634,GO:0006357,GO:0006954,GO:0032088,GO:0033085,GO:0043124,GO:0051059,GO:0070245 transcription cofactor activity|nucleus|regulation of transcription from RNA polymerase II promoter|inflammatory response|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell differentiation in thymus|negative regulation of I-kappaB kinase/NF-kappaB signaling|NF-kappaB binding|positive regulation of thymocyte apoptotic process NFKBIE 319.872785528439 372.246249728619 267.499321328259 0.718608505856743 -0.476722082891683 0.0137029857089593 0.480383008128687 5.47178 6.5595 4.08471 4.44752 GeneID:4794,Genbank:NM_004556.2,HGNC:HGNC:7799,MIM:604548 NFKB inhibitor epsilon GO:0001650,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0042942,GO:0042994,GO:0048471 fibrillar center|nucleus|cytoplasm|Golgi apparatus|cytosol|D-serine transport|cytoplasmic sequestering of transcription factor|perinuclear region of cytoplasm hsa04658,hsa04659,hsa04660,hsa04662,hsa04722,hsa04920,hsa05169 Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Epstein-Barr virus infection NFKBIL1 591.508353431835 579.706080887435 603.310625976236 1.04071812573135 0.0575793734639556 0.784246530701274 1 12.8355 14.1875 13.6261 15.2885 GeneID:4795,Genbank:NM_001144962.1,HGNC:HGNC:7800,MIM:601022 NFKB inhibitor like 1 GO:0005634,GO:0005829,GO:0007249,GO:0031665,GO:0032088,GO:0032720,GO:0034122,GO:0042994,GO:0071222 nucleus|cytosol|I-kappaB kinase/NF-kappaB signaling|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|cytoplasmic sequestering of transcription factor|cellular response to lipopolysaccharide NFKBIZ 82.2194199216264 81.0714697302109 83.3673701130419 1.02831946171041 0.0402885273991571 0.897146523746484 1 0.95187 0.711115 0.994731 0.718595 GeneID:64332,Genbank:NM_001005474.2,HGNC:HGNC:29805,MIM:608004 NFKB inhibitor zeta GO:0003712,GO:0005634,GO:0006351,GO:0006357,GO:0006954,GO:0016607,GO:0036464 transcription cofactor activity|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|inflammatory response|nuclear speck|cytoplasmic ribonucleoprotein granule hsa05202 Transcriptional misregulation in cancer NFRKB 739.405617122863 752.822696289658 725.988537956067 0.964355274534302 -0.0523633525987649 0.736462026368282 1 3.4497 3.66346 3.56176 3.14464 GeneID:4798,Genbank:XM_017017798.1,HGNC:HGNC:7802,MIM:164013 nuclear factor related to kappaB binding protein GO:0002020,GO:0003677,GO:0005634,GO:0005654,GO:0006281,GO:0006310,GO:0006355,GO:0006366,GO:0006954,GO:0016579,GO:0031011 protease binding|DNA binding|nucleus|nucleoplasm|DNA repair|DNA recombination|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|inflammatory response|protein deubiquitination|Ino80 complex NFS1 849.699118858327 793.679902094896 905.718335621757 1.14116324885025 0.19050519080264 0.223922053219196 1 12.1566 12.0096 13.3527 14.16 GeneID:9054,Genbank:NM_001198989.1,HGNC:HGNC:15910,MIM:603485 NFS1, cysteine desulfurase GO:0000096,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0006461,GO:0006777,GO:0018283,GO:0030170,GO:0031071,GO:0032324,GO:0042803,GO:0044281,GO:0044571,GO:0046872,GO:0051536 sulfur amino acid metabolic process|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|protein complex assembly|Mo-molybdopterin cofactor biosynthetic process|iron incorporation into metallo-sulfur cluster|pyridoxal phosphate binding|cysteine desulfurase activity|molybdopterin cofactor biosynthetic process|protein homodimerization activity|small molecule metabolic process|[2Fe-2S] cluster assembly|metal ion binding|iron-sulfur cluster binding hsa00730,hsa04122 Thiamine metabolism|Sulfur relay system NFU1 516.559817445275 532.034884728624 501.084750161926 0.941826869900674 -0.0864662122165062 0.616634513586711 1 6.15934 6.43931 6.28621 6.58539 GeneID:27247,Genbank:NM_001002755.2,HGNC:HGNC:16287,MIM:608100 NFU1 iron-sulfur cluster scaffold GO:0005506,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0016226,GO:0051539 iron ion binding|nucleus|nucleoplasm|mitochondrion|cytosol|iron-sulfur cluster assembly|4 iron, 4 sulfur cluster binding NFX1 1202.03665615266 1244.34535079009 1159.72796151523 0.931998468736087 -0.101600510338996 0.492624225623628 1 6.34237 6.62936 6.2333 6.10235 GeneID:4799,Genbank:NM_001318758.1,HGNC:HGNC:7803,MIM:603255 nuclear transcription factor, X-box binding 1 GO:0000122,GO:0000977,GO:0001078,GO:0003700,GO:0003723,GO:0005634,GO:0005730,GO:0005829,GO:0005886,GO:0006366,GO:0006954,GO:0008270,GO:0016032,GO:0016874,GO:0045347 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|RNA binding|nucleus|nucleolus|cytosol|plasma membrane|transcription from RNA polymerase II promoter|inflammatory response|zinc ion binding|viral process|ligase activity|negative regulation of MHC class II biosynthetic process hsa05165 Human papillomavirus infection NFXL1 182.59651405546 187.328686058987 177.864342051933 0.949477337368002 -0.0747945291171057 0.763202807277357 1 1.68859 1.61794 1.78939 1.55238 GeneID:152518,Genbank:NM_001278623.1,HGNC:HGNC:18726 nuclear transcription factor, X-box binding like 1 GO:0000977,GO:0001078,GO:0005634,GO:0006366,GO:0008270,GO:0016020,GO:0016021 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|transcription from RNA polymerase II promoter|zinc ion binding|membrane|integral component of membrane NFYA 1077.30534096568 1113.11411027171 1041.49657165965 0.935660200557003 -0.0959434069347507 0.526496304545614 1 6.59009 6.64923 6.55179 5.87283 GeneID:4800,Genbank:NM_002505.4,HGNC:HGNC:7804,MIM:189903 nuclear transcription factor Y subunit alpha GO:0001046,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0006355,GO:0006366,GO:0016602,GO:0032993,GO:0045540,GO:0045893,GO:0048511,GO:0090575 core promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|CCAAT-binding factor complex|protein-DNA complex|regulation of cholesterol biosynthetic process|positive regulation of transcription, DNA-templated|rhythmic process|RNA polymerase II transcription factor complex hsa04612,hsa05152 Antigen processing and presentation|Tuberculosis NFYB 314.924494919375 317.704245287297 312.144744551453 0.982501018421028 -0.0254691920757057 0.927395435294827 1 2.91373 2.74778 3.21271 2.06965 GeneID:4801,Genbank:NM_006166.3,HGNC:HGNC:7805,MIM:189904 nuclear transcription factor Y subunit beta GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0016602,GO:0032403,GO:0032993,GO:0043565,GO:0044212,GO:0045540,GO:0045893,GO:0046982,GO:0070491,GO:0090575,GO:1990830 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|CCAAT-binding factor complex|protein complex binding|protein-DNA complex|sequence-specific DNA binding|transcription regulatory region DNA binding|regulation of cholesterol biosynthetic process|positive regulation of transcription, DNA-templated|protein heterodimerization activity|repressing transcription factor binding|RNA polymerase II transcription factor complex|cellular response to leukemia inhibitory factor hsa04612,hsa05152,hsa05166 Antigen processing and presentation|Tuberculosis|Human T-cell leukemia virus 1 infection NFYC 1102.4829261635 1116.50639246583 1088.45945986116 0.974879738446705 -0.0367038364842614 0.805253473324311 1 6.47067 6.71473 6.42506 6.5498 GeneID:4802,Genbank:NM_001142588.1,HGNC:HGNC:7806,MIM:605344 nuclear transcription factor Y subunit gamma GO:0000978,GO:0000980,GO:0001077,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0006355,GO:0008134,GO:0016602,GO:0032993,GO:0045893,GO:0045944,GO:0046982,GO:0090575 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|regulation of transcription, DNA-templated|transcription factor binding|CCAAT-binding factor complex|protein-DNA complex|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|RNA polymerase II transcription factor complex hsa04612,hsa05152 Antigen processing and presentation|Tuberculosis NGDN 485.128720177493 526.355941658983 443.901498696004 0.843348509179744 -0.24579915462999 0.160017117620449 1 9.58741 10.1872 8.08779 8.71512 GeneID:25983,Genbank:NM_015514.1,HGNC:HGNC:20271,MIM:610777 neuroguidin GO:0000462,GO:0000775,GO:0003723,GO:0005634,GO:0005730,GO:0005739,GO:0006417,GO:0030175,GO:0030424,GO:0030425,GO:0032040 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|chromosome, centromeric region|RNA binding|nucleus|nucleolus|mitochondrion|regulation of translation|filopodium|axon|dendrite|small-subunit processome NGEF 1.23875045746879 0.538097676642304 1.93940323829528 3.60418437484629 1.84967281522267 0.680545261345893 1 0 0 0.0280051 0.00873106 GeneID:25791,Genbank:NM_019850.2,HGNC:HGNC:7807,MIM:605991 neuronal guanine nucleotide exchange factor GO:0005085,GO:0005089,GO:0005829,GO:0007186,GO:0016020,GO:0030426,GO:0035023,GO:0043065,GO:0043087,GO:0048013,GO:0051056,GO:0061002 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytosol|G-protein coupled receptor signaling pathway|membrane|growth cone|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of GTPase activity|ephrin receptor signaling pathway|regulation of small GTPase mediated signal transduction|negative regulation of dendritic spine morphogenesis hsa04360 Axon guidance NGF 24.5872923582042 22.5236671798228 26.6509175365856 1.18324060304266 0.242743464651735 0.701863508909568 1 0.184714 0.200427 0.185839 0.272882 GeneID:4803,Genbank:XM_006710663.3,HGNC:HGNC:7808,MIM:162030 nerve growth factor hsa04010,hsa04014,hsa04015,hsa04060,hsa04151,hsa04210,hsa04722,hsa04750 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Apoptosis|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels NGFR 54.5738066036895 48.0838153207596 61.0637978866194 1.26994493842205 0.344765946771049 0.389108984366629 1 0.519636 0.542832 0.737399 0.691311 GeneID:4804,Genbank:NM_002507.3,HGNC:HGNC:7809,MIM:162010 nerve growth factor receptor GO:0004871,GO:0004872,GO:0004888,GO:0005031,GO:0005035,GO:0005516,GO:0005576,GO:0005634,GO:0005654,GO:0005768,GO:0005829,GO:0005886,GO:0005887,GO:0006886,GO:0006919,GO:0006954,GO:0006955,GO:0007266,GO:0007411,GO:0009986,GO:0010977,GO:0015026,GO:0016021,GO:0017137,GO:0031293,GO:0031625,GO:0032496,GO:0032922,GO:0042593,GO:0043005,GO:0043065,GO:0043066,GO:0043121,GO:0043154,GO:0043281,GO:0048011,GO:0048406,GO:0050771,GO:0050772,GO:0051402,GO:0097190,GO:1900182,GO:1902895,GO:1903588,GO:1904646,GO:2001273 signal transducer activity|receptor activity|transmembrane signaling receptor activity|tumor necrosis factor-activated receptor activity|death receptor activity|calmodulin binding|extracellular region|nucleus|nucleoplasm|endosome|cytosol|plasma membrane|integral component of plasma membrane|intracellular protein transport|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|immune response|Rho protein signal transduction|axon guidance|cell surface|negative regulation of neuron projection development|coreceptor activity|integral component of membrane|Rab GTPase binding|membrane protein intracellular domain proteolysis|ubiquitin protein ligase binding|response to lipopolysaccharide|circadian regulation of gene expression|glucose homeostasis|neuron projection|positive regulation of apoptotic process|negative regulation of apoptotic process|neurotrophin binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|neurotrophin TRK receptor signaling pathway|nerve growth factor binding|negative regulation of axonogenesis|positive regulation of axonogenesis|neuron apoptotic process|apoptotic signaling pathway|positive regulation of protein localization to nucleus|positive regulation of pri-miRNA transcription from RNA polymerase II promoter|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|cellular response to amyloid-beta|regulation of glucose import in response to insulin stimulus hsa04010,hsa04014,hsa04015,hsa04060,hsa04151,hsa04215,hsa04722,hsa05202 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Apoptosis - multiple species|Neurotrophin signaling pathway|Transcriptional misregulation in cancer NGLY1 776.065167153555 857.147018974219 694.983315332891 0.81080993102514 -0.302564335444938 0.0603571901313319 0.880242025342909 7.04141 6.73316 6.14329 5.39156 GeneID:55768,Genbank:NM_001145294.1,HGNC:HGNC:17646,MIM:610661 N-glycanase 1 GO:0000224,GO:0005634,GO:0005737,GO:0005829,GO:0006457,GO:0006515,GO:0006516,GO:0006517,GO:0046872 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|nucleus|cytoplasm|cytosol|protein folding|protein quality control for misfolded or incompletely synthesized proteins|glycoprotein catabolic process|protein deglycosylation|metal ion binding hsa04141 Protein processing in endoplasmic reticulum NGRN 5256.92708836172 5115.21389462251 5398.64028210092 1.05540851141657 0.0778015234067589 0.561284269802311 1 120.522 124.497 130.97 132.608 GeneID:51335,Genbank:NM_001033088.1,HGNC:HGNC:18077,MIM:616718 neugrin, neurite outgrowth associated GO:0003723,GO:0005576,GO:0005634,GO:0030182 RNA binding|extracellular region|nucleus|neuron differentiation NHEJ1 330.564115390426 370.352590704836 290.775640076016 0.785131918539106 -0.348993017656908 0.0725090787860096 0.929707214174252 7.30783 7.03467 5.6749 5.43631 GeneID:79840,Genbank:NM_024782.2,HGNC:HGNC:25737,MIM:611290 non-homologous end joining factor 1 hsa03450 Non-homologous end-joining NHLH1 1.24038203510049 1.02816907859967 1.45259499160132 1.41279777989405 0.498554981013539 1 1 0.0230342 0.0203225 0 0.0602596 GeneID:4807,Genbank:NM_005598.3,HGNC:HGNC:7817,MIM:162360 nescient helix-loop-helix 1 GO:0000977,GO:0001228,GO:0005634,GO:0007417,GO:0030154,GO:0045944,GO:0046983 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|central nervous system development|cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity NHLH2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0112517 GeneID:4808,Genbank:NM_005599.3,HGNC:HGNC:7818,MIM:162361 nescient helix-loop-helix 2 GO:0000977,GO:0000978,GO:0000981,GO:0001077,GO:0001102,GO:0005634,GO:0005667,GO:0007417,GO:0007617,GO:0030154,GO:0042698,GO:0045944,GO:0046983,GO:0051091 RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|nucleus|transcription factor complex|central nervous system development|mating behavior|cell differentiation|ovulation cycle|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|positive regulation of DNA binding transcription factor activity NHLRC2 324.860932232194 334.683239566426 315.038624897962 0.941303858854978 -0.0872675856419775 0.681199175010305 1 2.28375 2.06188 2.37534 1.81055 GeneID:374354,Genbank:NM_198514.3,HGNC:HGNC:24731 NHL repeat containing 2 GO:0002576,GO:0005576,GO:0031093,GO:0045454 platelet degranulation|extracellular region|platelet alpha granule lumen|cell redox homeostasis NHLRC3 300.632888004778 281.862406360363 319.403369649193 1.13318896894974 0.180388462953812 0.359288816497335 1 3.28182 3.22459 4.37109 3.29476 GeneID:387921,Genbank:NM_001012754.3,HGNC:HGNC:33751 NHL repeat containing 3 GO:0005576,GO:0035578,GO:0043312,GO:0070062 extracellular region|azurophil granule lumen|neutrophil degranulation|extracellular exosome NHLRC4 2.21465176759163 2.00831188251439 2.42099165266886 1.20548589775698 0.269614773831291 1 1 0.0284915 0.0735948 4.83971e-06 0.147765 GeneID:283948,Genbank:NM_001301159.1,HGNC:HGNC:26700 NHL repeat containing 4 NHP2 3235.23142605711 3418.01553781365 3052.44731430058 0.893046646667116 -0.163192561021574 0.287008430030914 1 187.73 203.092 167.151 187.046 GeneID:55651,Genbank:NM_001034833.1,HGNC:HGNC:14377,MIM:606470 NHP2 ribonucleoprotein GO:0005732,GO:0015030,GO:0030515,GO:0031118,GO:0031429,GO:0034513,GO:0070034,GO:0090661,GO:1904874 small nucleolar ribonucleoprotein complex|Cajal body|snoRNA binding|rRNA pseudouridine synthesis|box H/ACA snoRNP complex|box H/ACA snoRNA binding|telomerase RNA binding|box H/ACA telomerase RNP complex|positive regulation of telomerase RNA localization to Cajal body hsa03008 Ribosome biogenesis in eukaryotes NHS 6.58767567965116 8.81147658012458 4.36387477917774 0.495248978930616 -1.01377409421633 0.41230622439182 1 0.0366218 0.0190995 0.0271415 0.00722974 GeneID:4810,Genbank:NM_001291867.1,HGNC:HGNC:7820,MIM:300457 NHS actin remodeling regulator GO:0002088,GO:0005794,GO:0005923,GO:0005925,GO:0016324,GO:0016604,GO:0030027,GO:0030054,GO:0030154 lens development in camera-type eye|Golgi apparatus|bicellular tight junction|focal adhesion|apical plasma membrane|nuclear body|lamellipodium|cell junction|cell differentiation NHSL1 807.162247912244 766.629922437872 847.694573386616 1.10574156914064 0.145014242276933 0.352524154428883 1 1.49763 1.4212 1.85038 1.45294 GeneID:57224,Genbank:XM_011535976.1,HGNC:HGNC:21021 NHS like 1 GO:0016020,GO:0097475 membrane|motor neuron migration NHSL2 1.02566752891457 1.56626675524197 0.48506830258717 0.309697119576692 -1.69107012999473 0.789536483244536 1 0.00338389 0.00156699 0.00160615 0 GeneID:340527,Genbank:XM_011530933.1,HGNC:HGNC:33737 NHS like 2 GO:0030154 cell differentiation NICN1 360.406602792119 331.65656726042 389.156638323818 1.17337232770141 0.230660873635721 0.217965012337133 1 4.75193 4.32554 5.46879 5.10238 GeneID:84276,Genbank:NM_032316.3,HGNC:HGNC:18317,MIM:611516 nicolin 1 GO:0005654,GO:0005874 nucleoplasm|microtubule NID1 3631.79793478247 3897.27456460833 3366.32130495661 0.863762932056834 -0.211292689531649 0.115224573886051 1 22.3396 22.7456 20.7334 18.6327 GeneID:4811,Genbank:NM_002508.2,HGNC:HGNC:7821,MIM:131390 nidogen 1 GO:0005509,GO:0005518,GO:0005576,GO:0005604,GO:0005605,GO:0007160,GO:0010811,GO:0022617,GO:0030198,GO:0031012,GO:0032836,GO:0043236,GO:0043237,GO:0043394,GO:0070062,GO:0071711,GO:0071944 calcium ion binding|collagen binding|extracellular region|basement membrane|basal lamina|cell-matrix adhesion|positive regulation of cell-substrate adhesion|extracellular matrix disassembly|extracellular matrix organization|extracellular matrix|glomerular basement membrane development|laminin binding|laminin-1 binding|proteoglycan binding|extracellular exosome|basement membrane organization|cell periphery NID2 2.47869750654259 1.56626675524197 3.3911282578432 2.16510262156417 1.11443540745223 0.65429160586858 1 0 0.00647543 0.0135172 0.0315866 GeneID:22795,Genbank:NM_007361.3,HGNC:HGNC:13389,MIM:605399 nidogen 2 GO:0005509,GO:0005518,GO:0005576,GO:0005604,GO:0005886,GO:0007155,GO:0007160,GO:0030198,GO:0031012,GO:0070062,GO:0071711 calcium ion binding|collagen binding|extracellular region|basement membrane|plasma membrane|cell adhesion|cell-matrix adhesion|extracellular matrix organization|extracellular matrix|extracellular exosome|basement membrane organization NIF3L1 859.410363197534 882.390600502577 836.43012589249 0.947913685182152 -0.0771723982416916 0.629194121330199 1 11.4142 11.1715 10.315 11.1953 GeneID:60491,Genbank:NM_001136039.2,HGNC:HGNC:13390,MIM:605778 NGG1 interacting factor 3 like 1 GO:0005634,GO:0005737,GO:0005739,GO:0008134,GO:0030182,GO:0042802,GO:0045893,GO:1903507 nucleus|cytoplasm|mitochondrion|transcription factor binding|neuron differentiation|identical protein binding|positive regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription NIFK 546.256087934191 642.788987569278 449.723188299103 0.699643579769065 -0.515307939477767 0.00253272245179317 0.183547885918187 12.724 14.2886 9.35114 8.84856 GeneID:84365,Genbank:NM_032390.4,HGNC:HGNC:17838,MIM:611970 nucleolar protein interacting with the FHA domain of MKI67 GO:0000794,GO:0003723,GO:0005654,GO:0005730,GO:0005737,GO:0006461,GO:0009303,GO:0016072 condensed nuclear chromosome|RNA binding|nucleoplasm|nucleolus|cytoplasm|protein complex assembly|rRNA transcription|rRNA metabolic process NIM1K 20.3149974753332 16.4026789829097 24.2273159677566 1.47703408650499 0.562703120526711 0.385658420161946 1 0.193551 0.190514 0.258799 0.382801 GeneID:167359,Genbank:NM_153361.3,HGNC:HGNC:28646 NIM1 serine/threonine protein kinase GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0035556 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|intracellular signal transduction NIN 281.330833848267 267.93849335171 294.723174344825 1.09996578191532 0.13745864463273 0.735247595065271 1 0.687167 0.522158 0.8807 0.477529 GeneID:51199,Genbank:NM_020921.3,HGNC:HGNC:14906,MIM:608684 ninein NINJ1 680.145797828307 687.173762738442 673.117832918172 0.979545304866914 -0.0298158748852644 0.841869323174911 1 18.7324 19.6525 18.2251 19.528 GeneID:4814,Genbank:NM_004148.3,HGNC:HGNC:7824,MIM:602062 ninjurin 1 GO:0001954,GO:0007155,GO:0007399,GO:0016021,GO:0042246,GO:1990384 positive regulation of cell-matrix adhesion|cell adhesion|nervous system development|integral component of membrane|tissue regeneration|hyaloid vascular plexus regression NINJ2 5.31316594199271 6.26506702096788 4.36126486301754 0.696124215179389 -0.522583333879625 0.762976790289507 1 0.193988 0.113936 0.0600694 0.084303 GeneID:4815,Genbank:NM_016533.5,HGNC:HGNC:7825,MIM:607297 ninjurin 2 GO:0005887,GO:0007158,GO:0007399,GO:0042246 integral component of plasma membrane|neuron cell-cell adhesion|nervous system development|tissue regeneration NINL 18.4935074944704 20.025283895351 16.9617310935898 0.847015761785408 -0.239539278531698 0.751996598349773 1 0.0478545 0.0507005 0.0450908 0.035103 GeneID:22981,Genbank:NM_001318226.1,HGNC:HGNC:29163,MIM:609580 ninein like GO:0000086,GO:0005509,GO:0005815,GO:0005829,GO:0005874,GO:0010389,GO:0045171,GO:0097711 G2/M transition of mitotic cell cycle|calcium ion binding|microtubule organizing center|cytosol|microtubule|regulation of G2/M transition of mitotic cell cycle|intercellular bridge|ciliary basal body-plasma membrane docking NIP7 1526.27832838275 1672.87911715634 1379.67753960915 0.824732358399217 -0.278002082020979 0.0572583619706995 0.867087558172753 31.8764 29.8003 25.3111 26.2192 GeneID:51388,Genbank:NM_016101.4,HGNC:HGNC:24328 NIP7, nucleolar pre-rRNA processing protein GO:0003723,GO:0005634,GO:0005730,GO:0005829,GO:0030687,GO:0042255,GO:0042273 RNA binding|nucleus|nucleolus|cytosol|preribosome, large subunit precursor|ribosome assembly|ribosomal large subunit biogenesis NIPA1 1257.2003063707 1354.59957357368 1159.80103916772 0.856194746989292 -0.223989110690706 0.129409464107393 1 8.90465 9.3266 8.75372 7.04519 GeneID:123606,Genbank:NM_001142275.1,HGNC:HGNC:17043,MIM:608145 NIPA magnesium transporter 1 GO:0005769,GO:0005886,GO:0015095,GO:0015693,GO:0016021 early endosome|plasma membrane|magnesium ion transmembrane transporter activity|magnesium ion transport|integral component of membrane NIPA2 4879.17257980137 5152.83168871194 4605.5134708908 0.893783020504994 -0.162003457254374 0.224447136731956 1 56.9194 58.3838 54.4454 49.244 GeneID:81614,Genbank:NM_001184888.1,HGNC:HGNC:17044,MIM:608146 NIPA magnesium transporter 2 GO:0005769,GO:0005886,GO:0015095,GO:0015693,GO:0016020,GO:0016021 early endosome|plasma membrane|magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane NIPAL1 3.42851911566455 2.49838328447175 4.35865494685735 1.74459018115746 0.802888175087998 0.740535422102725 1 0.00855761 0.0332681 0.00828691 0.0540463 GeneID:152519,Genbank:NM_207330.2,HGNC:HGNC:27194 NIPA like domain containing 1 GO:0015095,GO:0015693,GO:0016020,GO:0016021 magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane NIPAL2 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.016326 0 0 GeneID:79815,Genbank:NM_001321636.1,HGNC:HGNC:25854 NIPA like domain containing 2 GO:0015095,GO:0015693,GO:0016020,GO:0016021 magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane NIPAL3 3163.72435000131 3011.99257896955 3315.45612103307 1.10075175622356 0.138489146062684 0.318493884827965 1 12.2039 13.5007 15.0585 13.4555 GeneID:57185,Genbank:XM_011541808.2,HGNC:HGNC:25233 NIPA like domain containing 3 GO:0015095,GO:0015693,GO:0016020,GO:0016021 magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane NIPAL4 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0120256 0 0 GeneID:348938,Genbank:NM_001099287.1,HGNC:HGNC:28018,MIM:609383 NIPA like domain containing 4 GO:0015095,GO:0015693,GO:0016020,GO:0016021 magnesium ion transmembrane transporter activity|magnesium ion transport|membrane|integral component of membrane NIPBL 425.156648977222 401.505438021151 448.807859933293 1.11781265565237 0.160678414111878 0.385831493352789 1 0.940847 1.05502 1.26959 0.969118 GeneID:25836,Genbank:NM_015384.4,HGNC:HGNC:28862,MIM:608667 NIPBL, cohesin loading factor GO:0000122,GO:0000785,GO:0001656,GO:0003007,GO:0003151,GO:0003682,GO:0005634,GO:0005654,GO:0006351,GO:0006974,GO:0007064,GO:0007420,GO:0007605,GO:0008022,GO:0019827,GO:0031065,GO:0032039,GO:0032116,GO:0034088,GO:0034613,GO:0035115,GO:0035136,GO:0035261,GO:0036033,GO:0040018,GO:0042471,GO:0042634,GO:0042826,GO:0045444,GO:0045778,GO:0045892,GO:0045944,GO:0045995,GO:0047485,GO:0048557,GO:0048589,GO:0048592,GO:0048638,GO:0048703,GO:0050890,GO:0060325,GO:0061010,GO:0061038,GO:0070062,GO:0070087,GO:0071481,GO:0071921,GO:0090694,GO:2001224 negative regulation of transcription from RNA polymerase II promoter|chromatin|metanephros development|heart morphogenesis|outflow tract morphogenesis|chromatin binding|nucleus|nucleoplasm|transcription, DNA-templated|cellular response to DNA damage stimulus|mitotic sister chromatid cohesion|brain development|sensory perception of sound|protein C-terminus binding|stem cell population maintenance|positive regulation of histone deacetylation|integrator complex|SMC loading complex|maintenance of mitotic sister chromatid cohesion|cellular protein localization|embryonic forelimb morphogenesis|forelimb morphogenesis|external genitalia morphogenesis|mediator complex binding|positive regulation of multicellular organism growth|ear morphogenesis|regulation of hair cycle|histone deacetylase binding|fat cell differentiation|positive regulation of ossification|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of embryonic development|protein N-terminus binding|embryonic digestive tract morphogenesis|developmental growth|eye morphogenesis|regulation of developmental growth|embryonic viscerocranium morphogenesis|cognition|face morphogenesis|gall bladder development|uterus morphogenesis|extracellular exosome|chromo shadow domain binding|cellular response to X-ray|cohesin loading|Scc2-Scc4 cohesin loading complex|positive regulation of neuron migration NIPSNAP1 1986.89513358074 1812.45443116568 2161.3358359958 1.19249113182158 0.25397853740513 0.0760771082861748 0.94157495521624 27.381 31.6278 34.0059 36.2507 GeneID:8508,Genbank:NM_003634.3,HGNC:HGNC:7827,MIM:603249 nipsnap homolog 1 GO:0005739,GO:0005743,GO:0019233,GO:0042165,GO:0097060 mitochondrion|mitochondrial inner membrane|sensory perception of pain|neurotransmitter binding|synaptic membrane NIPSNAP2 1457.80891021175 1451.0533278616 1464.5644925619 1.00931128059933 0.0133711830857516 0.901179356004218 1 28.645 26.0233 28.8184 26.9807 GeneID:2631,Genbank:NM_001483.2,HGNC:HGNC:4179,MIM:603004 nipsnap homolog 2 GO:0005739,GO:0005741,GO:0005887,GO:0006119,GO:0006754,GO:0016020,GO:1901843,GO:2000984 mitochondrion|mitochondrial outer membrane|integral component of plasma membrane|oxidative phosphorylation|ATP biosynthetic process|membrane|positive regulation of high voltage-gated calcium channel activity|negative regulation of ATP citrate synthase activity NIPSNAP3A 412.572896650484 414.208059851611 410.937733449357 0.992104628762113 -0.0114358175853005 0.969787049336762 1 12.1907 11.5628 11.1545 12.3644 GeneID:25934,Genbank:NM_015469.2,HGNC:HGNC:23619,MIM:608871 nipsnap homolog 3A GO:0005634,GO:0005739,GO:0005829 nucleus|mitochondrion|cytosol NIPSNAP3B 2.75992747373762 4.06465003971372 1.45520490776151 0.358014809034827 -1.48190883008156 0.491168597136201 1 0.0256872 0.040962 0.0246252 0 GeneID:55335,Genbank:NM_018376.3,HGNC:HGNC:23641,MIM:608872 nipsnap homolog 3B GO:0005739 mitochondrion NISCH 1656.30353777173 1544.27275543798 1768.33432010547 1.14509196246485 0.195463465976647 0.171698460915872 1 7.69864 7.26719 8.55053 9.13361 GeneID:11188,Genbank:NM_007184.3,HGNC:HGNC:18006,MIM:615507 nischarin GO:0005178,GO:0005769,GO:0005829,GO:0005886,GO:0006006,GO:0006915,GO:0008217,GO:0016020,GO:0016601,GO:0030036,GO:0030336,GO:0032228,GO:0035091,GO:0042802,GO:0048243,GO:0055037 integrin binding|early endosome|cytosol|plasma membrane|glucose metabolic process|apoptotic process|regulation of blood pressure|membrane|Rac protein signal transduction|actin cytoskeleton organization|negative regulation of cell migration|regulation of synaptic transmission, GABAergic|phosphatidylinositol binding|identical protein binding|norepinephrine secretion|recycling endosome NIT1 444.467575209149 434.388248226979 454.546902191319 1.04640699661333 0.0654440923033818 0.782184635299762 1 3.6398 4.56457 4.0861 4.9743 GeneID:4817,Genbank:NM_001185092.1,HGNC:HGNC:7828,MIM:604618 nitrilase 1 GO:0000257,GO:0005634,GO:0005739,GO:0006807,GO:0070062 nitrilase activity|nucleus|mitochondrion|nitrogen compound metabolic process|extracellular exosome NIT2 571.06736439341 561.121585232632 581.013143554187 1.03544964022959 0.0502573888478684 0.787618378577361 1 17.5906 17.9553 18.1117 20.5187 GeneID:56954,Genbank:NM_020202.4,HGNC:HGNC:29878,MIM:616769 nitrilase family member 2 GO:0005576,GO:0005739,GO:0005813,GO:0005829,GO:0006107,GO:0006528,GO:0006541,GO:0035580,GO:0043312,GO:0050152,GO:0070062,GO:1904724 extracellular region|mitochondrion|centrosome|cytosol|oxaloacetate metabolic process|asparagine metabolic process|glutamine metabolic process|specific granule lumen|neutrophil degranulation|omega-amidase activity|extracellular exosome|tertiary granule lumen hsa00250 Alanine, aspartate and glutamate metabolism NKAIN1 4.95956994321867 3.13253351048394 6.7866063759534 2.16649122930051 1.11536039609731 0.436206735906489 1 0.0582092 0.0257667 0.12225 0.0636205 GeneID:79570,Genbank:XM_017002320.1,HGNC:HGNC:25743,MIM:612871 sodium/potassium transporting ATPase interacting 1 GO:0002028,GO:0005886,GO:0016021,GO:0051117 regulation of sodium ion transport|plasma membrane|integral component of membrane|ATPase binding NKAIN2 16.423162398669 17.8248669140969 15.0214578832411 0.842724826818277 -0.246866467031895 0.748939589126792 1 0.186487 0.23667 0.14371 0.16691 GeneID:154215,Genbank:XM_024446340.1,HGNC:HGNC:16443,MIM:609758 sodium/potassium transporting ATPase interacting 2 GO:0002028,GO:0005886,GO:0016021 regulation of sodium ion transport|plasma membrane|integral component of membrane NKAIN3 9.39518153585221 8.12930007942745 10.661062992277 1.31143676431094 0.391148244496171 0.734600814225165 1 0.013889 0.0134915 0.0214776 0.0200062 GeneID:286183,Genbank:XM_017013359.1,HGNC:HGNC:26829,MIM:612872 sodium/potassium transporting ATPase interacting 3 GO:0002028,GO:0005886,GO:0016021 regulation of sodium ion transport|plasma membrane|integral component of membrane NKAP 307.565232738574 320.990666276944 294.139799200204 0.916350006720838 -0.126029343166807 0.536308691251628 1 4.82475 4.77255 3.8668 4.64229 GeneID:79576,Genbank:NM_024528.3,HGNC:HGNC:29873,MIM:300766 NFKB activating protein GO:0000122,GO:0003682,GO:0003723,GO:0005654,GO:0005829,GO:0006351,GO:0007219,GO:0019827,GO:0030851,GO:0031490,GO:0033077,GO:0045892,GO:0046638,GO:0071425,GO:1903955 negative regulation of transcription from RNA polymerase II promoter|chromatin binding|RNA binding|nucleoplasm|cytosol|transcription, DNA-templated|Notch signaling pathway|stem cell population maintenance|granulocyte differentiation|chromatin DNA binding|T cell differentiation in thymus|negative regulation of transcription, DNA-templated|positive regulation of alpha-beta T cell differentiation|hematopoietic stem cell proliferation|positive regulation of protein targeting to mitochondrion NKAPD1 530.507688711214 548.292467886624 512.722909535804 0.935126669735367 -0.0967662930728003 0.598973645773835 1 4.98029 4.57426 4.54978 4.31817 GeneID:55216,Genbank:NM_018195.3,HGNC:HGNC:25569 NKAP domain containing 1 NKD1 5.53005537831213 5.72696934432558 5.33314141229868 0.931232750107679 -0.102786298252959 1 1 0.015 0.00783335 0.0162315 0.00568512 GeneID:85407,Genbank:NM_033119.4,HGNC:HGNC:17045,MIM:607851 naked cuticle homolog 1 GO:0001754,GO:0005509,GO:0005737,GO:0005886,GO:0007525,GO:0016055,GO:0030165,GO:0045732,GO:0090090,GO:0090249,GO:1901231,GO:1901233,GO:2000096 eye photoreceptor cell differentiation|calcium ion binding|cytoplasm|plasma membrane|somatic muscle development|Wnt signaling pathway|PDZ domain binding|positive regulation of protein catabolic process|negative regulation of canonical Wnt signaling pathway|regulation of cell motility involved in somitogenic axis elongation|positive regulation of non-canonical Wnt signaling pathway via JNK cascade|negative regulation of convergent extension involved in axis elongation|positive regulation of Wnt signaling pathway, planar cell polarity pathway hsa04310,hsa04390 Wnt signaling pathway|Hippo signaling pathway NKIRAS1 831.001738146884 930.233267449058 731.77020884471 0.786652374679541 -0.346201851938599 0.0298639107590453 0.68426379787821 6.14378 6.01238 4.83102 4.96575 GeneID:28512,Genbank:XM_005265078.4,HGNC:HGNC:17899,MIM:604496 NFKB inhibitor interacting Ras like 1 GO:0003924,GO:0005525,GO:0005737,GO:0007249,GO:0016020 GTPase activity|GTP binding|cytoplasm|I-kappaB kinase/NF-kappaB signaling|membrane NKIRAS2 1780.2097003336 1787.5950598348 1772.82434083239 0.991737100121675 -0.0119703680439293 0.917792884997877 1 26.6425 28.681 28.8608 26.3129 GeneID:28511,Genbank:NM_001001349.2,HGNC:HGNC:17898,MIM:604497 NFKB inhibitor interacting Ras like 2 GO:0003924,GO:0005525,GO:0005737,GO:0007249,GO:0016020 GTPase activity|GTP binding|cytoplasm|I-kappaB kinase/NF-kappaB signaling|membrane NKPD1 2.45424938317342 1.51824048055703 3.39025828578981 2.23301797653686 1.1589948653817 0.655793359616383 1 0.00809622 0.0138043 0.00745741 0.0348435 GeneID:284353,Genbank:NM_198478.3,HGNC:HGNC:24739 NTPase KAP family P-loop domain containing 1 GO:0016021 integral component of membrane NKRF 542.580289434446 683.905942058157 401.254636810735 0.586710265454331 -0.769279860351251 7.67051298378906e-06 0.00383909174838642 6.2676 6.43235 3.62938 3.81068 GeneID:55922,Genbank:XM_011531365.2,HGNC:HGNC:19374,MIM:300440 NFKB repressing factor GO:0000978,GO:0001077,GO:0003723,GO:0005634,GO:0005730,GO:0045892,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA binding|nucleus|nucleolus|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter NKTR 316.799753025098 341.774561912146 291.824944138049 0.853852148929281 -0.227941817164624 0.603613894553053 1 1.12597 0.957168 1.20059 0.629824 GeneID:4820,Genbank:XM_024453539.1,HGNC:HGNC:7833,MIM:161565 natural killer cell triggering receptor GO:0003755,GO:0005654,GO:0005739,GO:0005829,GO:0005886,GO:0006457,GO:0016018 peptidyl-prolyl cis-trans isomerase activity|nucleoplasm|mitochondrion|cytosol|plasma membrane|protein folding|cyclosporin A binding NKX1-2 16.5933305183836 17.1907166880847 15.9959443486824 0.930498980287986 -0.103923525617736 0.900954481400663 1 0.185661 0.309238 0.319092 0.16383 GeneID:390010,Genbank:NM_001146340.2,HGNC:HGNC:31652 NK1 homeobox 2 GO:0005634,GO:0006355,GO:0007275,GO:0043565 nucleus|regulation of transcription, DNA-templated|multicellular organism development|sequence-specific DNA binding NKX2-1 28.6359772621325 31.58508378848 25.6868707357851 0.813259540731497 -0.298212252585261 0.579013098393497 1 0.544534 0.732747 0.643311 0.449152 GeneID:7080,Genbank:NM_001079668.2,HGNC:HGNC:11825,MIM:600635 NK2 homeobox 1 NKX2-2 11.431748049501 12.6840215210985 10.1794745779034 0.802543149345096 -0.317349132966861 0.7344231385133 1 0.208492 0.279862 0.256181 0.140154 GeneID:4821,Genbank:XM_006723566.3,HGNC:HGNC:7835,MIM:604612 NK2 homeobox 2 hsa04950 Maturity onset diabetes of the young NKX2-3 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0487409 0 GeneID:159296,Genbank:NM_145285.2,HGNC:HGNC:7836,MIM:606727 NK2 homeobox 3 GO:0001776,GO:0002317,GO:0005634,GO:0006351,GO:0006641,GO:0022612,GO:0030225,GO:0042127,GO:0042475,GO:0043367,GO:0043565,GO:0045944,GO:0048535,GO:0048536,GO:0048541,GO:0048621,GO:0050900 leukocyte homeostasis|plasma cell differentiation|nucleus|transcription, DNA-templated|triglyceride metabolic process|gland morphogenesis|macrophage differentiation|regulation of cell proliferation|odontogenesis of dentin-containing tooth|CD4-positive, alpha-beta T cell differentiation|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|lymph node development|spleen development|Peyer's patch development|post-embryonic digestive tract morphogenesis|leukocyte migration NKX2-8 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0 0 0 0 GeneID:26257,Genbank:NM_014360.3,HGNC:HGNC:16364,MIM:603245 NK2 homeobox 8 GO:0000978,GO:0001077,GO:0001889,GO:0003690,GO:0003700,GO:0005634,GO:0006351,GO:0006366,GO:0007409,GO:0030324,GO:0043565,GO:0045944,GO:0050680 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|liver development|double-stranded DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|transcription from RNA polymerase II promoter|axonogenesis|lung development|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|negative regulation of epithelial cell proliferation NKX3-1 263.475988860351 249.230553183923 277.721424536779 1.1143153236587 0.156157537442431 0.467652681345791 1 2.95671 3.41383 4.19123 3.08027 GeneID:4824,Genbank:NM_006167.3,HGNC:HGNC:7838,MIM:602041 NK3 homeobox 1 hsa05200,hsa05215 Pathways in cancer|Prostate cancer NKX3-2 66.5713395874853 57.5294421268964 75.6132370480743 1.31433982761886 0.394338338243756 0.269155215273915 1 1.74846 1.53989 2.59604 1.80586 GeneID:579,Genbank:NM_001189.3,HGNC:HGNC:951,MIM:602183 NK3 homeobox 2 GO:0000978,GO:0001078,GO:0001501,GO:0005634,GO:0006366,GO:0007368,GO:0031016,GO:0032331,GO:0042474,GO:0043066,GO:0048536,GO:0048645,GO:0048705,GO:0048706,GO:0060576 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|skeletal system development|nucleus|transcription from RNA polymerase II promoter|determination of left/right symmetry|pancreas development|negative regulation of chondrocyte differentiation|middle ear morphogenesis|negative regulation of apoptotic process|spleen development|animal organ formation|skeletal system morphogenesis|embryonic skeletal system development|intestinal epithelial cell development NKX6-1 34.680841858148 28.6446553767358 40.7170283395602 1.42145289597825 0.507366291864866 0.304166225645092 1 0.724148 1.04212 1.81328 1.41049 GeneID:4825,Genbank:NM_006168.2,HGNC:HGNC:7839,MIM:602563 NK6 homeobox 1 GO:0000122,GO:0000978,GO:0001078,GO:0001764,GO:0003682,GO:0005634,GO:0006366,GO:0007224,GO:0009887,GO:0021912,GO:0021913,GO:0030516,GO:0031016,GO:0032024,GO:0035094,GO:0044342,GO:0045666,GO:0045686,GO:0045687,GO:0045944,GO:0048709,GO:0051091,GO:0051594,GO:0070062,GO:0071345,GO:0071375,GO:0072560,GO:2000078,GO:2001222 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|neuron migration|chromatin binding|nucleus|transcription from RNA polymerase II promoter|smoothened signaling pathway|animal organ morphogenesis|regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification|regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification|regulation of axon extension|pancreas development|positive regulation of insulin secretion|response to nicotine|type B pancreatic cell proliferation|positive regulation of neuron differentiation|negative regulation of glial cell differentiation|positive regulation of glial cell differentiation|positive regulation of transcription from RNA polymerase II promoter|oligodendrocyte differentiation|positive regulation of DNA binding transcription factor activity|detection of glucose|extracellular exosome|cellular response to cytokine stimulus|cellular response to peptide hormone stimulus|type B pancreatic cell maturation|positive regulation of type B pancreatic cell development|regulation of neuron migration hsa04950 Maturity onset diabetes of the young NKX6-2 24.1604636673337 25.0602680838715 23.2606592507958 0.928188763701458 -0.107509861988505 0.92885637991002 1 0.663374 0.333275 0.495475 0.528133 GeneID:84504,Genbank:XM_017016789.2,HGNC:HGNC:19321,MIM:605955 NK6 homeobox 2 GO:0000978,GO:0001078,GO:0003677,GO:0003700,GO:0005634,GO:0006355,GO:0010454,GO:0010455,GO:0021912,GO:0021913,GO:0022010,GO:0031018,GO:0031641,GO:0045686,GO:0045687,GO:0045892,GO:0050885 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|negative regulation of cell fate commitment|positive regulation of cell fate commitment|regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification|regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification|central nervous system myelination|endocrine pancreas development|regulation of myelination|negative regulation of glial cell differentiation|positive regulation of glial cell differentiation|negative regulation of transcription, DNA-templated|neuromuscular process controlling balance NLE1 762.181303598453 819.307693820734 705.054913376173 0.86054960632463 -0.216669736165441 0.241753919135971 1 5.19427 5.19747 4.0892 5.13624 GeneID:54475,Genbank:XM_017024777.1,HGNC:HGNC:19889 notchless homolog 1 GO:0000027,GO:0001756,GO:0001822,GO:0001826,GO:0005634,GO:0005730,GO:0005840,GO:0007219,GO:0045930,GO:0048705,GO:0061484,GO:0090263,GO:2001268 ribosomal large subunit assembly|somitogenesis|kidney development|inner cell mass cell differentiation|nucleus|nucleolus|ribosome|Notch signaling pathway|negative regulation of mitotic cell cycle|skeletal system morphogenesis|hematopoietic stem cell homeostasis|positive regulation of canonical Wnt signaling pathway|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway NLGN1 272.156236578489 253.94795375901 290.364519397968 1.14340168959785 0.193332327247724 0.647724450828696 1 0.387461 0.366786 0.578885 0.306524 GeneID:22871,Genbank:XM_017005901.1,HGNC:HGNC:14291,MIM:600568 neuroligin 1 GO:0001540,GO:0002087,GO:0004872,GO:0005794,GO:0005886,GO:0005887,GO:0006605,GO:0007157,GO:0007158,GO:0007399,GO:0007416,GO:0009897,GO:0009986,GO:0010841,GO:0014069,GO:0016080,GO:0016339,GO:0017146,GO:0023041,GO:0030054,GO:0030165,GO:0030425,GO:0031175,GO:0032230,GO:0032433,GO:0035418,GO:0042043,GO:0043197,GO:0043198,GO:0045184,GO:0045202,GO:0045664,GO:0046983,GO:0048488,GO:0048511,GO:0048789,GO:0050804,GO:0050839,GO:0051260,GO:0051290,GO:0051491,GO:0051965,GO:0051968,GO:0052689,GO:0060076,GO:0060291,GO:0060999,GO:0061002,GO:0071277,GO:0072553,GO:0089717,GO:0097091,GO:0097104,GO:0097105,GO:0097110,GO:0097113,GO:0097114,GO:0097115,GO:0097119,GO:0097120,GO:0098793,GO:0098794,GO:0098942,GO:0098985,GO:0099054,GO:0099055,GO:0099560,GO:0140058,GO:1900029,GO:1900244,GO:1902474,GO:1902533,GO:1904861,GO:1905520,GO:2000302,GO:2000310,GO:2000311,GO:2000463,GO:2000809 amyloid-beta binding|regulation of respiratory gaseous exchange by neurological system process|receptor activity|Golgi apparatus|plasma membrane|integral component of plasma membrane|protein targeting|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|neuron cell-cell adhesion|nervous system development|synapse assembly|external side of plasma membrane|cell surface|positive regulation of circadian sleep/wake cycle, wakefulness|postsynaptic density|synaptic vesicle targeting|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|NMDA selective glutamate receptor complex|neuronal signal transduction|cell junction|PDZ domain binding|dendrite|neuron projection development|positive regulation of synaptic transmission, GABAergic|filopodium tip|protein localization to synapse|neurexin family protein binding|dendritic spine|dendritic shaft|establishment of protein localization|synapse|regulation of neuron differentiation|protein dimerization activity|synaptic vesicle endocytosis|rhythmic process|cytoskeletal matrix organization at active zone|modulation of chemical synaptic transmission|cell adhesion molecule binding|protein homooligomerization|protein heterotetramerization|positive regulation of filopodium assembly|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|carboxylic ester hydrolase activity|excitatory synapse|long-term synaptic potentiation|positive regulation of dendritic spine development|negative regulation of dendritic spine morphogenesis|cellular response to calcium ion|terminal button organization|spanning component of membrane|synaptic vesicle clustering|postsynaptic membrane assembly|presynaptic membrane assembly|scaffold protein binding|AMPA glutamate receptor clustering|NMDA glutamate receptor clustering|neurexin clustering involved in presynaptic membrane assembly|postsynaptic density protein 95 clustering|receptor localization to synapse|presynapse|postsynapse|retrograde trans-synaptic signaling by trans-synaptic protein complex|asymmetric, glutamatergic, excitatory synapse|presynapse assembly|integral component of postsynaptic membrane|synaptic membrane adhesion|neuron projection arborization|positive regulation of ruffle assembly|positive regulation of synaptic vesicle endocytosis|positive regulation of protein localization to synapse|positive regulation of intracellular signal transduction|excitatory synapse assembly|positive regulation of presynaptic active zone assembly|positive regulation of synaptic vesicle exocytosis|regulation of NMDA receptor activity|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of synaptic vesicle clustering hsa04514 Cell adhesion molecules (CAMs) NLGN2 1435.87928703438 1323.33207339863 1548.42650067012 1.17009670648531 0.226627771006255 0.121457612828164 1 11.6991 11.501 14.4287 13.0743 GeneID:57555,Genbank:XM_017024897.1,HGNC:HGNC:14290,MIM:606479 neuroligin 2 GO:0002087,GO:0004872,GO:0005886,GO:0005887,GO:0007158,GO:0007416,GO:0009986,GO:0016020,GO:0019233,GO:0030054,GO:0032024,GO:0032230,GO:0035418,GO:0035641,GO:0042043,GO:0042734,GO:0042802,GO:0045202,GO:0045211,GO:0045217,GO:0048488,GO:0050804,GO:0050808,GO:0050839,GO:0050885,GO:0051965,GO:0051968,GO:0052689,GO:0060077,GO:0072553,GO:0089717,GO:0097104,GO:0097105,GO:0097116,GO:0097119,GO:0097151,GO:0098609,GO:0098983,GO:0099054,GO:0099055,GO:1902474,GO:1904862,GO:2000311,GO:2000463,GO:2000809 regulation of respiratory gaseous exchange by neurological system process|receptor activity|plasma membrane|integral component of plasma membrane|neuron cell-cell adhesion|synapse assembly|cell surface|membrane|sensory perception of pain|cell junction|positive regulation of insulin secretion|positive regulation of synaptic transmission, GABAergic|protein localization to synapse|locomotory exploration behavior|neurexin family protein binding|presynaptic membrane|identical protein binding|synapse|postsynaptic membrane|cell-cell junction maintenance|synaptic vesicle endocytosis|modulation of chemical synaptic transmission|synapse organization|cell adhesion molecule binding|neuromuscular process controlling balance|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|carboxylic ester hydrolase activity|inhibitory synapse|terminal button organization|spanning component of membrane|postsynaptic membrane assembly|presynaptic membrane assembly|gephyrin clustering involved in postsynaptic density assembly|postsynaptic density protein 95 clustering|positive regulation of inhibitory postsynaptic potential|cell-cell adhesion|symmetric, GABA-ergic, inhibitory synapse|presynapse assembly|integral component of postsynaptic membrane|positive regulation of protein localization to synapse|inhibitory synapse assembly|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of synaptic vesicle clustering hsa04514 Cell adhesion molecules (CAMs) NLGN3 8.99770529590483 10.7237359132691 7.27167467854057 0.678091547325677 -0.560448033978808 0.591030687161788 1 0.0388412 0.0473731 0.0409053 0.0190639 GeneID:54413,Genbank:XM_006724663.4,HGNC:HGNC:14289,MIM:300336 neuroligin 3 GO:0002087,GO:0004872,GO:0005886,GO:0005887,GO:0006898,GO:0007158,GO:0007416,GO:0007612,GO:0008542,GO:0009986,GO:0030054,GO:0030139,GO:0030534,GO:0035176,GO:0042043,GO:0045202,GO:0048488,GO:0048675,GO:0048709,GO:0050804,GO:0050808,GO:0050839,GO:0051965,GO:0051968,GO:0052689,GO:0060024,GO:0060076,GO:0060079,GO:0060080,GO:0060291,GO:0061002,GO:0071625,GO:0089717,GO:0090394,GO:0097104,GO:0097105,GO:0097110,GO:0098983,GO:0098985,GO:0099054,GO:0099055,GO:1900271,GO:2000310,GO:2000331,GO:2000463,GO:2000809,GO:2000969 regulation of respiratory gaseous exchange by neurological system process|receptor activity|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|neuron cell-cell adhesion|synapse assembly|learning|visual learning|cell surface|cell junction|endocytic vesicle|adult behavior|social behavior|neurexin family protein binding|synapse|synaptic vesicle endocytosis|axon extension|oligodendrocyte differentiation|modulation of chemical synaptic transmission|synapse organization|cell adhesion molecule binding|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|carboxylic ester hydrolase activity|rhythmic synaptic transmission|excitatory synapse|excitatory postsynaptic potential|inhibitory postsynaptic potential|long-term synaptic potentiation|negative regulation of dendritic spine morphogenesis|vocalization behavior|spanning component of membrane|negative regulation of excitatory postsynaptic potential|postsynaptic membrane assembly|presynaptic membrane assembly|scaffold protein binding|symmetric, GABA-ergic, inhibitory synapse|asymmetric, glutamatergic, excitatory synapse|presynapse assembly|integral component of postsynaptic membrane|regulation of long-term synaptic potentiation|regulation of NMDA receptor activity|regulation of terminal button organization|positive regulation of excitatory postsynaptic potential|positive regulation of synaptic vesicle clustering|positive regulation of AMPA receptor activity hsa04514 Cell adhesion molecules (CAMs) NLGN4X 337.376282137422 322.89311695498 351.859447319863 1.08970872664629 0.123942561810423 0.514044289520144 1 1.57009 1.4127 1.78508 1.46282 GeneID:57502,Genbank:NM_181332.2,HGNC:HGNC:14287,MIM:300427 neuroligin 4, X-linked GO:0003360,GO:0004872,GO:0005886,GO:0005887,GO:0007158,GO:0007612,GO:0009986,GO:0014069,GO:0016021,GO:0021549,GO:0030054,GO:0030182,GO:0030425,GO:0030534,GO:0031404,GO:0035176,GO:0035265,GO:0042043,GO:0042803,GO:0045202,GO:0045211,GO:0045216,GO:0048488,GO:0050808,GO:0050839,GO:0052689,GO:0060076,GO:0071625,GO:0089717,GO:0090394,GO:0097104,GO:0097105,GO:0097110,GO:0098983,GO:0098985,GO:0099054 brainstem development|receptor activity|plasma membrane|integral component of plasma membrane|neuron cell-cell adhesion|learning|cell surface|postsynaptic density|integral component of membrane|cerebellum development|cell junction|neuron differentiation|dendrite|adult behavior|chloride ion binding|social behavior|organ growth|neurexin family protein binding|protein homodimerization activity|synapse|postsynaptic membrane|cell-cell junction organization|synaptic vesicle endocytosis|synapse organization|cell adhesion molecule binding|carboxylic ester hydrolase activity|excitatory synapse|vocalization behavior|spanning component of membrane|negative regulation of excitatory postsynaptic potential|postsynaptic membrane assembly|presynaptic membrane assembly|scaffold protein binding|symmetric, GABA-ergic, inhibitory synapse|asymmetric, glutamatergic, excitatory synapse|presynapse assembly hsa04514 Cell adhesion molecules (CAMs) NLGN4Y 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0 0 GeneID:22829,Genbank:XM_011531426.2,HGNC:HGNC:15529,MIM:400028 neuroligin 4, Y-linked GO:0004872,GO:0005886,GO:0005887,GO:0007158,GO:0007612,GO:0009986,GO:0014069,GO:0030054,GO:0035176,GO:0042043,GO:0045202,GO:0045211,GO:0048488,GO:0050804,GO:0050839,GO:0052689,GO:0071625,GO:0089717,GO:0097104,GO:0097105,GO:0097110,GO:0098983,GO:0098985,GO:0099054 receptor activity|plasma membrane|integral component of plasma membrane|neuron cell-cell adhesion|learning|cell surface|postsynaptic density|cell junction|social behavior|neurexin family protein binding|synapse|postsynaptic membrane|synaptic vesicle endocytosis|modulation of chemical synaptic transmission|cell adhesion molecule binding|carboxylic ester hydrolase activity|vocalization behavior|spanning component of membrane|postsynaptic membrane assembly|presynaptic membrane assembly|scaffold protein binding|symmetric, GABA-ergic, inhibitory synapse|asymmetric, glutamatergic, excitatory synapse|presynapse assembly hsa04514 Cell adhesion molecules (CAMs) NLK 474.31872565995 491.599089739587 457.038361580313 0.929697330852297 -0.105166981192902 0.574591398460944 1 5.52818 4.86721 5.35048 4.08397 GeneID:51701,Genbank:XM_005257988.2,HGNC:HGNC:29858,MIM:609476 nemo like kinase GO:0000287,GO:0004672,GO:0004674,GO:0004707,GO:0005524,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0006468,GO:0007179,GO:0008134,GO:0016055,GO:0018107,GO:0030178,GO:0031625,GO:0035556,GO:0042169,GO:0042501,GO:0046777,GO:0050821 magnesium ion binding|protein kinase activity|protein serine/threonine kinase activity|MAP kinase activity|ATP binding|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|transforming growth factor beta receptor signaling pathway|transcription factor binding|Wnt signaling pathway|peptidyl-threonine phosphorylation|negative regulation of Wnt signaling pathway|ubiquitin protein ligase binding|intracellular signal transduction|SH2 domain binding|serine phosphorylation of STAT protein|protein autophosphorylation|protein stabilization hsa04010,hsa04068,hsa04310,hsa04520 MAPK signaling pathway|FoxO signaling pathway|Wnt signaling pathway|Adherens junction NLN 1151.99675107855 1161.15767397118 1142.83582818592 0.984221052664966 -0.0229457185833989 0.913976711128711 1 5.02928 4.47988 5.15384 4.25391 GeneID:57486,Genbank:NM_020726.4,HGNC:HGNC:16058,MIM:611530 neurolysin GO:0004222,GO:0005576,GO:0005758,GO:0005886,GO:0006111,GO:0006518,GO:0042277,GO:0046872,GO:1902809 metalloendopeptidase activity|extracellular region|mitochondrial intermembrane space|plasma membrane|regulation of gluconeogenesis|peptide metabolic process|peptide binding|metal ion binding|regulation of skeletal muscle fiber differentiation hsa04614 Renin-angiotensin system NLRC3 2.74992127499723 2.10436443188427 3.39547811811019 1.6135409184187 0.690230164159661 0.827627127483769 1 0.00593887 0.00530498 0.0390417 0 GeneID:197358,Genbank:NM_178844.3,HGNC:HGNC:29889,MIM:615648 NLR family CARD domain containing 3 GO:0005524,GO:0005737,GO:0005815,GO:0005829,GO:0007249,GO:0014067,GO:0032088,GO:0032687,GO:0032688,GO:0032715,GO:0032720,GO:0036312,GO:0042110,GO:0043124,GO:0045824,GO:0048147,GO:0048471,GO:0050680,GO:0050728,GO:1900016,GO:1900226,GO:1901223 ATP binding|cytoplasm|microtubule organizing center|cytosol|I-kappaB kinase/NF-kappaB signaling|negative regulation of phosphatidylinositol 3-kinase signaling|negative regulation of NF-kappaB transcription factor activity|negative regulation of interferon-alpha production|negative regulation of interferon-beta production|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|phosphatidylinositol 3-kinase regulatory subunit binding|T cell activation|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of innate immune response|negative regulation of fibroblast proliferation|perinuclear region of cytoplasm|negative regulation of epithelial cell proliferation|negative regulation of inflammatory response|negative regulation of cytokine production involved in inflammatory response|negative regulation of NLRP3 inflammasome complex assembly|negative regulation of NIK/NF-kappaB signaling NLRC5 483.119785497058 377.685061424835 588.554509569281 1.5583208595779 0.639992316109838 0.383965114176542 1 1.60023 1.84452 4.02654 1.51121 GeneID:84166,Genbank:NM_001330552.1,HGNC:HGNC:29933,MIM:613537 NLR family CARD domain containing 5 GO:0000979,GO:0005524,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0032088,GO:0032480,GO:0043549,GO:0045087,GO:0045345,GO:0045944,GO:0051607,GO:0060335,GO:0060339,GO:0060340 RNA polymerase II core promoter sequence-specific DNA binding|ATP binding|nucleus|cytoplasm|centrosome|cytosol|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of kinase activity|innate immune response|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|defense response to virus|positive regulation of interferon-gamma-mediated signaling pathway|negative regulation of type I interferon-mediated signaling pathway|positive regulation of type I interferon-mediated signaling pathway NLRP1 2.96963888055335 2.54640955915669 3.39286820195 1.33241260807772 0.414040910824943 0.922281812887816 1 0.0122979 0.0166706 0.0230977 0.0107872 GeneID:22861,Genbank:NM_001033053.2,HGNC:HGNC:14374,MIM:606636 NLR family pyrin domain containing 1 GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005829,GO:0006915,GO:0006919,GO:0006954,GO:0008656,GO:0016032,GO:0019899,GO:0019904,GO:0032495,GO:0042742,GO:0045087,GO:0050718,GO:0050727,GO:0051402,GO:0072558,GO:1904784 ATP binding|intracellular|nucleus|nucleoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|cysteine-type endopeptidase activator activity involved in apoptotic process|viral process|enzyme binding|protein domain specific binding|response to muramyl dipeptide|defense response to bacterium|innate immune response|positive regulation of interleukin-1 beta secretion|regulation of inflammatory response|neuron apoptotic process|NLRP1 inflammasome complex|NLRP1 inflammasome complex assembly hsa04621 NOD-like receptor signaling pathway NLRP10 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0119069 0 0 GeneID:338322,Genbank:XM_011520043.3,HGNC:HGNC:21464,MIM:609662 NLR family pyrin domain containing 10 GO:0002250,GO:0002827,GO:0003924,GO:0005524,GO:0005737,GO:0006954,GO:0016887,GO:0019897,GO:0045087,GO:0050717,GO:0050729,GO:0050829,GO:0050832,GO:1900426,GO:2000318,GO:2000484,GO:2000778 adaptive immune response|positive regulation of T-helper 1 type immune response|GTPase activity|ATP binding|cytoplasm|inflammatory response|ATPase activity|extrinsic component of plasma membrane|innate immune response|positive regulation of interleukin-1 alpha secretion|positive regulation of inflammatory response|defense response to Gram-negative bacterium|defense response to fungus|positive regulation of defense response to bacterium|positive regulation of T-helper 17 type immune response|positive regulation of interleukin-8 secretion|positive regulation of interleukin-6 secretion NLRP11 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00946186 GeneID:204801,Genbank:NM_145007.3,HGNC:HGNC:22945,MIM:609664 NLR family pyrin domain containing 11 GO:0003723,GO:0005524,GO:0016715 RNA binding|ATP binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen NLRP12 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0 0.00908194 GeneID:91662,Genbank:NM_001277129.1,HGNC:HGNC:22938,MIM:609648 NLR family pyrin domain containing 12 GO:0005524,GO:0005737,GO:0006919,GO:0007165,GO:0008588,GO:0008656,GO:0009968,GO:0031953,GO:0032088,GO:0036336,GO:0043122,GO:0043124,GO:0043281,GO:0045345,GO:0045381,GO:0045409,GO:0045751,GO:0050710,GO:0050711,GO:0050718,GO:0050728,GO:0050729,GO:0070373,GO:0071345,GO:1901223 ATP binding|cytoplasm|activation of cysteine-type endopeptidase activity involved in apoptotic process|signal transduction|release of cytoplasmic sequestered NF-kappaB|cysteine-type endopeptidase activator activity involved in apoptotic process|negative regulation of signal transduction|negative regulation of protein autophosphorylation|negative regulation of NF-kappaB transcription factor activity|dendritic cell migration|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of MHC class I biosynthetic process|regulation of interleukin-18 biosynthetic process|negative regulation of interleukin-6 biosynthetic process|negative regulation of Toll signaling pathway|negative regulation of cytokine secretion|negative regulation of interleukin-1 secretion|positive regulation of interleukin-1 beta secretion|negative regulation of inflammatory response|positive regulation of inflammatory response|negative regulation of ERK1 and ERK2 cascade|cellular response to cytokine stimulus|negative regulation of NIK/NF-kappaB signaling hsa04621 NOD-like receptor signaling pathway NLRP2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0103656 0 GeneID:55655,Genbank:NM_001174081.2,HGNC:HGNC:22948,MIM:609364 NLR family pyrin domain containing 2 GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0006915,GO:0006954,GO:0032088,GO:0032090,GO:0043231,GO:0043280,GO:0045087,GO:0050718 ATP binding|cytoplasm|Golgi apparatus|cytosol|apoptotic process|inflammatory response|negative regulation of NF-kappaB transcription factor activity|Pyrin domain binding|intracellular membrane-bounded organelle|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|innate immune response|positive regulation of interleukin-1 beta secretion NLRP3 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0248011 0 GeneID:114548,Genbank:NM_001127461.2,HGNC:HGNC:16400,MIM:606416 NLR family pyrin domain containing 3 hsa04217,hsa04621,hsa04625,hsa05133,hsa05164 Necroptosis|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Pertussis|Influenza A NLRP4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:147945,Genbank:NM_134444.4,HGNC:HGNC:22943,MIM:609645 NLR family pyrin domain containing 4 GO:0005524,GO:0005829,GO:0006954,GO:0032479,GO:0070062 ATP binding|cytosol|inflammatory response|regulation of type I interferon production|extracellular exosome NLRP7 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:199713,Genbank:NM_139176.3,HGNC:HGNC:22947,MIM:609661 NLR family pyrin domain containing 7 hsa04621 NOD-like receptor signaling pathway NLRX1 357.253767121548 367.009351786251 347.498182456846 0.94683740554718 -0.0788113929007626 0.655621840322707 1 3.4162 4.03205 3.84244 3.5502 GeneID:79671,Genbank:NM_001282358.1,HGNC:HGNC:29890,MIM:611947 NLR family member X1 GO:0005524,GO:0005739,GO:0005741,GO:0005886,GO:0016032,GO:0030054,GO:0032480,GO:0032688,GO:0032715,GO:0039536,GO:0043124,GO:0045087,GO:0045824,GO:0050728 ATP binding|mitochondrion|mitochondrial outer membrane|plasma membrane|viral process|cell junction|negative regulation of type I interferon production|negative regulation of interferon-beta production|negative regulation of interleukin-6 production|negative regulation of RIG-I signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of innate immune response|negative regulation of inflammatory response hsa04621,hsa04622,hsa05164 NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Influenza A NMB 221.060546346982 217.741521944813 224.379570749151 1.03048591166742 0.0433247811445267 0.860705915791832 1 4.73124 5.23847 4.85572 5.59708 GeneID:4828,Genbank:NM_205858.1,HGNC:HGNC:7842,MIM:162340 neuromedin B GO:0005179,GO:0005576,GO:0007165,GO:0007186,GO:0007218,GO:0007267 hormone activity|extracellular region|signal transduction|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|cell-cell signaling hsa04080 Neuroactive ligand-receptor interaction NMBR 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0189223 0 0 0.0168482 GeneID:4829,Genbank:XM_017010901.1,HGNC:HGNC:7843,MIM:162341 neuromedin B receptor GO:0004946,GO:0005829,GO:0005886,GO:0005887,GO:0007186,GO:0007200 bombesin receptor activity|cytosol|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway hsa04080 Neuroactive ligand-receptor interaction NMD3 519.187921065773 554.191925019473 484.183917112074 0.873675517908458 -0.194830530979337 0.409847172086484 1 5.45333 4.43314 4.87989 3.92032 GeneID:51068,Genbank:NM_001320227.1,HGNC:HGNC:24250,MIM:611021 NMD3 ribosome export adaptor GO:0000055,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0016020,GO:0030674,GO:0032092,GO:0043023,GO:1902680,GO:1904751 ribosomal large subunit export from nucleus|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|membrane|protein binding, bridging|positive regulation of protein binding|ribosomal large subunit binding|positive regulation of RNA biosynthetic process|positive regulation of protein localization to nucleolus hsa03008,hsa03013 Ribosome biogenesis in eukaryotes|RNA transport NME1 1318.19761779869 1405.09552828465 1231.29970731273 0.876310316648657 -0.190486251301816 0.309564933827052 1 142.446 147.24 111.873 131.81 GeneID:4830,Genbank:NM_198175.1,HGNC:HGNC:7849,MIM:156490 NME/NM23 nucleoside diphosphate kinase 1 GO:0000287,GO:0000977,GO:0002762,GO:0003697,GO:0003723,GO:0004536,GO:0004550,GO:0005524,GO:0005525,GO:0005634,GO:0005737,GO:0005741,GO:0005813,GO:0005829,GO:0005882,GO:0006183,GO:0006228,GO:0006241,GO:0006897,GO:0007595,GO:0008285,GO:0010629,GO:0010976,GO:0014075,GO:0015949,GO:0016020,GO:0019215,GO:0019899,GO:0021766,GO:0032587,GO:0033574,GO:0035690,GO:0042802,GO:0042981,GO:0043015,GO:0043024,GO:0043209,GO:0043388,GO:0048471,GO:0050679,GO:0051591,GO:0070062,GO:0071333,GO:0071398 magnesium ion binding|RNA polymerase II regulatory region sequence-specific DNA binding|negative regulation of myeloid leukocyte differentiation|single-stranded DNA binding|RNA binding|deoxyribonuclease activity|nucleoside diphosphate kinase activity|ATP binding|GTP binding|nucleus|cytoplasm|mitochondrial outer membrane|centrosome|cytosol|intermediate filament|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|endocytosis|lactation|negative regulation of cell proliferation|negative regulation of gene expression|positive regulation of neuron projection development|response to amine|nucleobase-containing small molecule interconversion|membrane|intermediate filament binding|enzyme binding|hippocampus development|ruffle membrane|response to testosterone|cellular response to drug|identical protein binding|regulation of apoptotic process|gamma-tubulin binding|ribosomal small subunit binding|myelin sheath|positive regulation of DNA binding|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|response to cAMP|extracellular exosome|cellular response to glucose stimulus|cellular response to fatty acid hsa00230,hsa00240,hsa00983 Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME2 17.4845892077732 21.3994455518532 13.5697328636932 0.634116095709687 -0.657181097785503 0.33734216725588 1 258.862 208.884 203.248 242.808 GeneID:4831,Genbank:NM_001018137.2,HGNC:HGNC:7850,MIM:156491 NME/NM23 nucleoside diphosphate kinase 2 GO:0001726,GO:0003677,GO:0003700,GO:0004550,GO:0004673,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006183,GO:0006228,GO:0006241,GO:0006351,GO:0006355,GO:0007155,GO:0007229,GO:0009142,GO:0015949,GO:0030027,GO:0034774,GO:0043066,GO:0043312,GO:0045618,GO:0045682,GO:0045944,GO:0046872,GO:0050679,GO:0070062,GO:0071944,GO:1904813 ruffle|DNA binding|DNA binding transcription factor activity|nucleoside diphosphate kinase activity|protein histidine kinase activity|ATP binding|extracellular region|nucleus|cytoplasm|cytosol|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|cell adhesion|integrin-mediated signaling pathway|nucleoside triphosphate biosynthetic process|nucleobase-containing small molecule interconversion|lamellipodium|secretory granule lumen|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of keratinocyte differentiation|regulation of epidermis development|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|positive regulation of epithelial cell proliferation|extracellular exosome|cell periphery|ficolin-1-rich granule lumen hsa00230,hsa00240,hsa00983 Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME3 599.992226953642 569.520442650808 630.464011256477 1.10700857079337 0.146666391941706 0.39895953562795 1 27.765 29.6092 29.4016 30.2348 GeneID:4832,Genbank:XM_011522503.2,HGNC:HGNC:7851,MIM:601817 NME/NM23 nucleoside diphosphate kinase 3 GO:0004550,GO:0005524,GO:0005622,GO:0005739,GO:0005829,GO:0006183,GO:0006228,GO:0006241,GO:0006915,GO:0015949,GO:0042981,GO:0046872,GO:0070062 nucleoside diphosphate kinase activity|ATP binding|intracellular|mitochondrion|cytosol|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|apoptotic process|nucleobase-containing small molecule interconversion|regulation of apoptotic process|metal ion binding|extracellular exosome hsa00230,hsa00240,hsa00983 Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME4 1509.48102206495 1596.75943872295 1422.20260540694 0.890680568980624 -0.167019974223331 0.457064722121582 1 23.9887 25.837 19.8821 25.4301 GeneID:4833,Genbank:NM_001286436.1,HGNC:HGNC:7852,MIM:601818 NME/NM23 nucleoside diphosphate kinase 4 GO:0004550,GO:0005524,GO:0005622,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0006183,GO:0006228,GO:0006241,GO:0006869,GO:0009116,GO:0015949,GO:0042981,GO:0046872,GO:1901612 nucleoside diphosphate kinase activity|ATP binding|intracellular|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|lipid transport|nucleoside metabolic process|nucleobase-containing small molecule interconversion|regulation of apoptotic process|metal ion binding|cardiolipin binding hsa00230,hsa00240,hsa00983 Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME5 4.18568115875977 3.03648096111406 5.33488135640547 1.75692896636775 0.813055863548558 0.710077670457681 1 0 0.0595467 0.156278 0 GeneID:8382,Genbank:NM_003551.2,HGNC:HGNC:7853,MIM:603575 NME/NM23 family member 5 GO:0003351,GO:0004550,GO:0005622,GO:0006183,GO:0006228,GO:0006241,GO:0007283,GO:0007286,GO:0009116,GO:0021591,GO:0036126,GO:0060271,GO:1902176 epithelial cilium movement|nucleoside diphosphate kinase activity|intracellular|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|spermatogenesis|spermatid development|nucleoside metabolic process|ventricular system development|sperm flagellum|cilium assembly|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway NME6 858.106779176366 885.063505577283 831.150052775449 0.939085215397432 -0.0906720166109214 0.5400422630329 1 3.14413 3.81066 3.31114 3.25614 GeneID:10201,Genbank:XM_024453298.1,HGNC:HGNC:20567,MIM:608294 NME/NM23 nucleoside diphosphate kinase 6 GO:0004550,GO:0005524,GO:0005739,GO:0005829,GO:0006183,GO:0006228,GO:0006241,GO:0006915,GO:0015949,GO:0030308,GO:0045839,GO:0046872 nucleoside diphosphate kinase activity|ATP binding|mitochondrion|cytosol|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|apoptotic process|nucleobase-containing small molecule interconversion|negative regulation of cell growth|negative regulation of mitotic nuclear division|metal ion binding hsa00230,hsa00240,hsa00983 Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME7 318.736972987444 342.812539645853 294.661406329034 0.859540921791942 -0.218361768434848 0.279048142349353 1 8.76743 7.49898 7.38162 6.21776 GeneID:29922,Genbank:NM_197972.2,HGNC:HGNC:20461,MIM:613465 NME/NM23 family member 7 GO:0004550,GO:0005524,GO:0005813,GO:0005829,GO:0006183,GO:0006228,GO:0006241,GO:0015949,GO:0046872 nucleoside diphosphate kinase activity|ATP binding|centrosome|cytosol|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|nucleobase-containing small molecule interconversion|metal ion binding hsa00230,hsa00240,hsa00983 Purine metabolism|Pyrimidine metabolism|Drug metabolism - other enzymes NME9 8.41373377385739 6.169014471598 10.6584530761168 1.72774000210051 0.78888613075254 0.457089215727731 1 0.0214439 0.0167154 0.0170532 0.0381129 GeneID:347736,Genbank:NM_178130.3,HGNC:HGNC:21343 NME/NM23 family member 9 GO:0004550,GO:0005622,GO:0005737,GO:0005856,GO:0006183,GO:0006228,GO:0006241,GO:0045454 nucleoside diphosphate kinase activity|intracellular|cytoplasm|cytoskeleton|GTP biosynthetic process|UTP biosynthetic process|CTP biosynthetic process|cell redox homeostasis NMI 154.93610513211 146.499889218218 163.372321046003 1.11517027021537 0.157264005428941 0.779565396318041 1 2.08634 2.47096 3.47751 1.68857 GeneID:9111,Genbank:XM_005246941.2,HGNC:HGNC:7854,MIM:603525 N-myc and STAT interactor GO:0003712,GO:0005654,GO:0005737,GO:0005829,GO:0006366,GO:0006954,GO:0007259,GO:0042802,GO:0045355,GO:0045358,GO:0045824,GO:0060333,GO:1902524 transcription cofactor activity|nucleoplasm|cytoplasm|cytosol|transcription from RNA polymerase II promoter|inflammatory response|JAK-STAT cascade|identical protein binding|negative regulation of interferon-alpha biosynthetic process|negative regulation of interferon-beta biosynthetic process|negative regulation of innate immune response|interferon-gamma-mediated signaling pathway|positive regulation of protein K48-linked ubiquitination NMNAT1 262.570681270904 244.089707790924 281.051654750884 1.15142771604127 0.203423844928347 0.388101828973749 1 1.47293 1.62313 1.62566 2.0142 GeneID:64802,Genbank:NM_001297778.1,HGNC:HGNC:17877,MIM:608700 nicotinamide nucleotide adenylyltransferase 1 GO:0000309,GO:0004515,GO:0005524,GO:0005634,GO:0005654,GO:0009435,GO:0009611,GO:0016604,GO:0019674,GO:0034628,GO:0042802,GO:1990966 nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|ATP binding|nucleus|nucleoplasm|NAD biosynthetic process|response to wounding|nuclear body|NAD metabolic process|'de novo' NAD biosynthetic process from aspartate|identical protein binding|ATP generation from poly-ADP-D-ribose hsa00760 Nicotinate and nicotinamide metabolism NMNAT2 981.039858062707 886.648372641886 1075.43134348353 1.21291751799999 0.278481446238855 0.072113730357786 0.929024313086611 4.42975 4.91325 6.0696 5.29966 GeneID:23057,Genbank:NM_015039.3,HGNC:HGNC:16789,MIM:608701 nicotinamide nucleotide adenylyltransferase 2 GO:0000139,GO:0000309,GO:0004515,GO:0005524,GO:0005770,GO:0005794,GO:0005802,GO:0009435,GO:0019674,GO:0034628,GO:0045202 Golgi membrane|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|ATP binding|late endosome|Golgi apparatus|trans-Golgi network|NAD biosynthetic process|NAD metabolic process|'de novo' NAD biosynthetic process from aspartate|synapse hsa00760 Nicotinate and nicotinamide metabolism NMNAT3 6.37001173155863 4.01662376502878 8.72339969808849 2.17182395175765 1.1189071628937 0.380358726920857 1 0.0112961 0.0104713 0.0429831 0.0250472 GeneID:349565,Genbank:NM_178177.4,HGNC:HGNC:20989,MIM:608702 nicotinamide nucleotide adenylyltransferase 3 GO:0000309,GO:0004515,GO:0005524,GO:0005739,GO:0005759,GO:0009435,GO:0009611,GO:0019674,GO:0034628 nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|ATP binding|mitochondrion|mitochondrial matrix|NAD biosynthetic process|response to wounding|NAD metabolic process|'de novo' NAD biosynthetic process from aspartate hsa00760 Nicotinate and nicotinamide metabolism NMRAL1 8.93456135663421 8.17732635411239 9.69179635915603 1.18520356647892 0.245134872732879 0.860909685331661 1 0.0689829 0.0456972 0.128928 0.0149751 GeneID:57407,Genbank:NM_001351994.1,HGNC:HGNC:24987 NmrA like redox sensor 1 GO:0000050,GO:0005634,GO:0005829,GO:0042802,GO:0048471 urea cycle|nucleus|cytosol|identical protein binding|perinuclear region of cytoplasm NMRK1 194.642713646849 193.007629128628 196.277798165071 1.01694321126687 0.0242391176308255 0.924672098881895 1 0.95047 1.03156 0.933444 0.991249 GeneID:54981,Genbank:NM_001330678.1,HGNC:HGNC:26057,MIM:608704 nicotinamide riboside kinase 1 GO:0005524,GO:0005829,GO:0009435,GO:0019674,GO:0046872,GO:0050262,GO:0061769 ATP binding|cytosol|NAD biosynthetic process|NAD metabolic process|metal ion binding|ribosylnicotinamide kinase activity|ribosylnicotinate kinase activity hsa00760 Nicotinate and nicotinamide metabolism NMT1 5165.90498310873 4870.51844557005 5461.29152064742 1.12129572686758 0.165166819998435 0.214116003268014 1 35.5935 35.9895 41.9402 39.4903 GeneID:4836,Genbank:NM_021079.4,HGNC:HGNC:7857,MIM:160993 N-myristoyltransferase 1 NMT2 760.354985408133 888.243048361597 632.46692245467 0.712042637002657 -0.489964462753857 0.0021288794232914 0.164715617601136 4.36278 4.92502 3.55493 3.11445 GeneID:9397,Genbank:XM_017016947.2,HGNC:HGNC:7858,MIM:603801 N-myristoyltransferase 2 GO:0004379,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0018008,GO:0019898,GO:0022400,GO:0043657,GO:0075733 glycylpeptide N-tetradecanoyltransferase activity|cytoplasm|Golgi apparatus|cytosol|plasma membrane|N-terminal peptidyl-glycine N-myristoylation|extrinsic component of membrane|regulation of rhodopsin mediated signaling pathway|host cell|intracellular transport of virus NMU 582.319109787033 546.746835442453 617.891384131613 1.13012338449401 0.176480291649404 0.308229202360496 1 8.79158 10.2481 9.97579 11.3819 GeneID:10874,Genbank:NM_001292045.1,HGNC:HGNC:7859,MIM:605103 neuromedin U GO:0001659,GO:0001696,GO:0005102,GO:0005576,GO:0006940,GO:0007165,GO:0007186,GO:0007204,GO:0007218,GO:0007586,GO:0009648,GO:0010460,GO:0019233,GO:0031652,GO:0031839,GO:0031840,GO:0042755,GO:0043195,GO:0044497,GO:0045187,GO:0050806,GO:0060455,GO:0097009,GO:0120061,GO:0120069,GO:1902722,GO:1903999,GO:1904058,GO:2000821 temperature homeostasis|gastric acid secretion|receptor binding|extracellular region|regulation of smooth muscle contraction|signal transduction|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|digestion|photoperiodism|positive regulation of heart rate|sensory perception of pain|positive regulation of heat generation|type 1 neuromedin U receptor binding|type 2 neuromedin U receptor binding|eating behavior|terminal bouton|positive regulation of blood pressure in other organism|regulation of circadian sleep/wake cycle, sleep|positive regulation of synaptic transmission|negative regulation of gastric acid secretion|energy homeostasis|negative regulation of gastric emptying|positive regulation of stomach fundus smooth muscle contraction|positive regulation of prolactin secretion|negative regulation of eating behavior|positive regulation of sensory perception of pain|regulation of grooming behavior hsa04080 Neuroactive ligand-receptor interaction NMUR2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0217165 0 GeneID:56923,Genbank:NM_020167.4,HGNC:HGNC:16454,MIM:605108 neuromedin U receptor 2 GO:0001607,GO:0002023,GO:0004930,GO:0005229,GO:0005525,GO:0005622,GO:0005886,GO:0006816,GO:0006940,GO:0007186,GO:0007200,GO:0007204,GO:0007218,GO:0007267,GO:0007417,GO:0007625,GO:0007631,GO:0016021,GO:0019722,GO:0042924,GO:0043006,GO:0048016,GO:0048265,GO:0050482,GO:0051930 neuromedin U receptor activity|reduction of food intake in response to dietary excess|G-protein coupled receptor activity|intracellular calcium activated chloride channel activity|GTP binding|intracellular|plasma membrane|calcium ion transport|regulation of smooth muscle contraction|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|cell-cell signaling|central nervous system development|grooming behavior|feeding behavior|integral component of membrane|calcium-mediated signaling|neuromedin U binding|activation of phospholipase A2 activity by calcium-mediated signaling|inositol phosphate-mediated signaling|response to pain|arachidonic acid secretion|regulation of sensory perception of pain hsa04080 Neuroactive ligand-receptor interaction NNAT 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:4826,Genbank:NM_005386.3,HGNC:HGNC:7860,MIM:603106 neuronatin GO:0005737,GO:0007420,GO:0032024 cytoplasm|brain development|positive regulation of insulin secretion NNMT 1719.71987900684 1459.45421928149 1979.9855387322 1.35666162910337 0.440060936757283 0.0391472491716289 0.753859521009372 37.8718 39.3266 47.5223 57.6102 GeneID:4837,Genbank:NM_006169.2,HGNC:HGNC:7861,MIM:600008 nicotinamide N-methyltransferase hsa00760 Nicotinate and nicotinamide metabolism NNT 3678.87468299592 3371.8378798209 3985.91148617094 1.18211836637373 0.24137450085437 0.0734408626700978 0.934750619674839 15.7847 15.1871 20.6158 16.4128 GeneID:23530,Genbank:XM_017009293.2,HGNC:HGNC:7863,MIM:607878 nicotinamide nucleotide transhydrogenase GO:0003957,GO:0005739,GO:0005743,GO:0005746,GO:0006099,GO:0006740,GO:0008746,GO:0008750,GO:0015992,GO:0016020,GO:0016021,GO:0050661,GO:0051287,GO:0055114,GO:0072593 NAD(P)+ transhydrogenase (B-specific) activity|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain|tricarboxylic acid cycle|NADPH regeneration|NAD(P)+ transhydrogenase activity|NAD(P)+ transhydrogenase (AB-specific) activity|proton transport|membrane|integral component of membrane|NADP binding|NAD binding|oxidation-reduction process|reactive oxygen species metabolic process hsa00760 Nicotinate and nicotinamide metabolism NOA1 1124.12876075632 1190.85113273759 1057.40638877505 0.887941707998576 -0.171463125904048 0.256598228251053 1 23.9454 23.007 20.3921 21.5103 GeneID:84273,Genbank:NM_032313.3,HGNC:HGNC:28473,MIM:614919 nitric oxide associated 1 GO:0003723,GO:0003924,GO:0005525,GO:0005739,GO:0005743,GO:0006915,GO:0010941,GO:0032543,GO:0042254,GO:0043457 RNA binding|GTPase activity|GTP binding|mitochondrion|mitochondrial inner membrane|apoptotic process|regulation of cell death|mitochondrial translation|ribosome biogenesis|regulation of cellular respiration NOB1 1779.82646018196 1909.07188158787 1650.58103877605 0.864598685201516 -0.209897452563671 0.138170842536136 1 36.6008 36.3673 31.6175 32.4932 GeneID:28987,Genbank:NM_014062.2,HGNC:HGNC:29540,MIM:613586 NIN1 (RPN12) binding protein 1 homolog GO:0000469,GO:0004521,GO:0005654,GO:0005829,GO:0006364,GO:0007601,GO:0030490,GO:0030688,GO:0046872 cleavage involved in rRNA processing|endoribonuclease activity|nucleoplasm|cytosol|rRNA processing|visual perception|maturation of SSU-rRNA|preribosome, small subunit precursor|metal ion binding hsa03008 Ribosome biogenesis in eukaryotes NOC2L 4101.49197663569 4152.13806858892 4050.84588468246 0.975604813174991 -0.0356312191573638 0.774048531877013 1 48.9146 52.2678 49.2943 51.3268 GeneID:26155,Genbank:NM_015658.3,HGNC:HGNC:24517,MIM:610770 NOC2 like nucleolar associated transcriptional repressor GO:0000122,GO:0002903,GO:0003682,GO:0003714,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006351,GO:0006915,GO:0030690,GO:0030691,GO:0031491,GO:0031497,GO:0034644,GO:0035067,GO:0042273,GO:0042393,GO:0070491,GO:1901796,GO:2001243 negative regulation of transcription from RNA polymerase II promoter|negative regulation of B cell apoptotic process|chromatin binding|transcription corepressor activity|RNA binding|nucleus|nucleoplasm|nucleolus|cytosol|transcription, DNA-templated|apoptotic process|Noc1p-Noc2p complex|Noc2p-Noc3p complex|nucleosome binding|chromatin assembly|cellular response to UV|negative regulation of histone acetylation|ribosomal large subunit biogenesis|histone binding|repressing transcription factor binding|regulation of signal transduction by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway NOC3L 396.140118578397 446.253789076724 346.02644808007 0.775402823572614 -0.366982106320333 0.0513419770070203 0.82808973186751 3.85041 3.26744 2.86938 2.68585 GeneID:64318,Genbank:NM_022451.10,HGNC:HGNC:24034,MIM:610769 NOC3 like DNA replication regulator GO:0003682,GO:0003723,GO:0005634,GO:0005730,GO:0005739,GO:0016607,GO:0045444 chromatin binding|RNA binding|nucleus|nucleolus|mitochondrion|nuclear speck|fat cell differentiation NOC4L 499.001148969128 548.773747634328 449.228550303928 0.818604301391015 -0.288761847384177 0.0978308158927765 1 16.1272 15.2435 12.46 13.3651 GeneID:79050,Genbank:XM_017019960.1,HGNC:HGNC:28461,MIM:612819 nucleolar complex associated 4 homolog GO:0000462,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0016021,GO:0030692,GO:0031965,GO:0032040 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleoplasm|nucleolus|rRNA processing|integral component of membrane|Noc4p-Nop14p complex|nuclear membrane|small-subunit processome NOCT 267.690918310017 288.20492562134 247.176910998695 0.85764290969631 -0.22155100618891 0.279565175774587 1 5.54051 6.06099 5.55181 4.54304 GeneID:25819,Genbank:NM_012118.3,HGNC:HGNC:14254,MIM:608468 nocturnin GO:0000290,GO:0000932,GO:0003700,GO:0003729,GO:0004535,GO:0005634,GO:0005654,GO:0005737,GO:0006366,GO:0006397,GO:0007623,GO:0009991,GO:0010629,GO:0032496,GO:0032922,GO:0033962,GO:0042752,GO:0045600,GO:0045668,GO:0045995,GO:0046872,GO:0048255,GO:0048471 deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|DNA binding transcription factor activity|mRNA binding|poly(A)-specific ribonuclease activity|nucleus|nucleoplasm|cytoplasm|transcription from RNA polymerase II promoter|mRNA processing|circadian rhythm|response to extracellular stimulus|negative regulation of gene expression|response to lipopolysaccharide|circadian regulation of gene expression|cytoplasmic mRNA processing body assembly|regulation of circadian rhythm|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|regulation of embryonic development|metal ion binding|mRNA stabilization|perinuclear region of cytoplasm NOD1 244.99316813624 243.791741487707 246.194594784773 1.00985617183914 0.0141498326302835 0.966336650921261 1 1.24324 1.40549 1.40927 1.22114 GeneID:10392,Genbank:NM_001354849.1,HGNC:HGNC:16390,MIM:605980 nucleotide binding oligomerization domain containing 1 GO:0000187,GO:0002606,GO:0005524,GO:0005737,GO:0005829,GO:0006915,GO:0006919,GO:0006952,GO:0006954,GO:0007165,GO:0007254,GO:0008656,GO:0009595,GO:0016045,GO:0016323,GO:0016324,GO:0016579,GO:0032731,GO:0032755,GO:0032760,GO:0035556,GO:0042228,GO:0042742,GO:0042802,GO:0042803,GO:0042834,GO:0043123,GO:0043280,GO:0045087,GO:0046330,GO:0050700,GO:0050830,GO:0051000,GO:0051092,GO:0051259,GO:0070374,GO:0070423,GO:0070498,GO:0071225,GO:1901224,GO:1904417 activation of MAPK activity|positive regulation of dendritic cell antigen processing and presentation|ATP binding|cytoplasm|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|defense response|inflammatory response|signal transduction|JNK cascade|cysteine-type endopeptidase activator activity involved in apoptotic process|detection of biotic stimulus|detection of bacterium|basolateral plasma membrane|apical plasma membrane|protein deubiquitination|positive regulation of interleukin-1 beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|intracellular signal transduction|interleukin-8 biosynthetic process|defense response to bacterium|identical protein binding|protein homodimerization activity|peptidoglycan binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|innate immune response|positive regulation of JNK cascade|CARD domain binding|defense response to Gram-positive bacterium|positive regulation of nitric-oxide synthase activity|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|positive regulation of ERK1 and ERK2 cascade|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|cellular response to muramyl dipeptide|positive regulation of NIK/NF-kappaB signaling|positive regulation of xenophagy hsa04621,hsa05120,hsa05131,hsa05133 NOD-like receptor signaling pathway|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Pertussis NOD2 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0097876 GeneID:64127,Genbank:XM_017023536.1,HGNC:HGNC:5331,MIM:605956 nucleotide binding oligomerization domain containing 2 hsa04621,hsa04668,hsa05131,hsa05152,hsa05321 NOD-like receptor signaling pathway|TNF signaling pathway|Shigellosis|Tuberculosis|Inflammatory bowel disease (IBD) NODAL 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:4838,Genbank:NM_001329906.1,HGNC:HGNC:7865,MIM:601265 nodal growth differentiation factor GO:0000122,GO:0001831,GO:0001842,GO:0001889,GO:0001890,GO:0001892,GO:0001893,GO:0001944,GO:0001947,GO:0002085,GO:0005125,GO:0005160,GO:0005615,GO:0007420,GO:0008083,GO:0009880,GO:0010085,GO:0010470,GO:0010575,GO:0010721,GO:0010862,GO:0016015,GO:0019827,GO:0022409,GO:0030509,GO:0032927,GO:0033505,GO:0035987,GO:0042074,GO:0043280,GO:0045766,GO:0045944,GO:0048327,GO:0048382,GO:0048468,GO:0048546,GO:0048701,GO:0048859,GO:0050679,GO:0051091,GO:0060136,GO:0060137,GO:0060391,GO:0060395,GO:0060460,GO:0060766,GO:0060802,GO:0070374,GO:0070698,GO:0090010,GO:1900164,GO:1900224,GO:1901164,GO:1901383,GO:2000036 negative regulation of transcription from RNA polymerase II promoter|trophectodermal cellular morphogenesis|neural fold formation|liver development|placenta development|embryonic placenta development|maternal placenta development|vasculature development|heart looping|inhibition of neuroepithelial cell differentiation|cytokine activity|transforming growth factor beta receptor binding|extracellular space|brain development|growth factor activity|embryonic pattern specification|polarity specification of proximal/distal axis|regulation of gastrulation|positive regulation of vascular endothelial growth factor production|negative regulation of cell development|positive regulation of pathway-restricted SMAD protein phosphorylation|morphogen activity|stem cell population maintenance|positive regulation of cell-cell adhesion|BMP signaling pathway|positive regulation of activin receptor signaling pathway|floor plate morphogenesis|endodermal cell differentiation|cell migration involved in gastrulation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of angiogenesis|positive regulation of transcription from RNA polymerase II promoter|axial mesodermal cell fate specification|mesendoderm development|cell development|digestive tract morphogenesis|embryonic cranial skeleton morphogenesis|formation of anatomical boundary|positive regulation of epithelial cell proliferation|positive regulation of DNA binding transcription factor activity|embryonic process involved in female pregnancy|maternal process involved in parturition|positive regulation of SMAD protein import into nucleus|SMAD protein signal transduction|left lung morphogenesis|negative regulation of androgen receptor signaling pathway|epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification|positive regulation of ERK1 and ERK2 cascade|type I activin receptor binding|transforming growth factor beta receptor signaling pathway involved in primitive streak formation|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|negative regulation of trophoblast cell migration|negative regulation of chorionic trophoblast cell proliferation|regulation of stem cell population maintenance hsa04060,hsa04350,hsa04550 Cytokine-cytokine receptor interaction|TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells NOG 12.9803097248508 16.7486715608123 9.21194788888925 0.550010659379274 -0.862468516096248 0.279111741610368 1 0.435126 0.717948 0.511573 0.170848 GeneID:9241,Genbank:NM_005450.4,HGNC:HGNC:7866,MIM:602991 noggin GO:0000122,GO:0001501,GO:0001649,GO:0001701,GO:0001706,GO:0001707,GO:0001837,GO:0001839,GO:0001843,GO:0003149,GO:0003151,GO:0003203,GO:0003223,GO:0005576,GO:0005615,GO:0007399,GO:0008045,GO:0009953,GO:0010628,GO:0019955,GO:0021510,GO:0021533,GO:0021983,GO:0030336,GO:0030509,GO:0030514,GO:0035019,GO:0042060,GO:0042474,GO:0042733,GO:0042803,GO:0045668,GO:0045944,GO:0048318,GO:0048570,GO:0048706,GO:0048712,GO:0050679,GO:0051216,GO:0055009,GO:0060044,GO:0060173,GO:0060272,GO:0060302,GO:0060325,GO:0060394,GO:0060412,GO:0060425,GO:0060513,GO:0060676,GO:0060825,GO:0061037,GO:0061053,GO:0061312,GO:0061384,GO:0061626,GO:0090090,GO:0090190,GO:0090193,GO:1905006,GO:2000313,GO:2001234 negative regulation of transcription from RNA polymerase II promoter|skeletal system development|osteoblast differentiation|in utero embryonic development|endoderm formation|mesoderm formation|epithelial to mesenchymal transition|neural plate morphogenesis|neural tube closure|membranous septum morphogenesis|outflow tract morphogenesis|endocardial cushion morphogenesis|ventricular compact myocardium morphogenesis|extracellular region|extracellular space|nervous system development|motor neuron axon guidance|dorsal/ventral pattern formation|positive regulation of gene expression|cytokine binding|spinal cord development|cell differentiation in hindbrain|pituitary gland development|negative regulation of cell migration|BMP signaling pathway|negative regulation of BMP signaling pathway|somatic stem cell population maintenance|wound healing|middle ear morphogenesis|embryonic digit morphogenesis|protein homodimerization activity|negative regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|axial mesoderm development|notochord morphogenesis|embryonic skeletal system development|negative regulation of astrocyte differentiation|positive regulation of epithelial cell proliferation|cartilage development|atrial cardiac muscle tissue morphogenesis|negative regulation of cardiac muscle cell proliferation|limb development|embryonic skeletal joint morphogenesis|negative regulation of cytokine activity|face morphogenesis|negative regulation of pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|lung morphogenesis|prostatic bud formation|ureteric bud formation|fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|negative regulation of cartilage development|somite development|BMP signaling pathway involved in heart development|heart trabecula morphogenesis|pharyngeal arch artery morphogenesis|negative regulation of canonical Wnt signaling pathway|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of glomerulus development|negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|negative regulation of apoptotic signaling pathway hsa04350 TGF-beta signaling pathway NOL10 529.151128531126 535.378123647209 522.924133415042 0.976737954574377 -0.0339565361169767 0.866450091863759 1 2.85634 2.54355 2.68346 2.56878 GeneID:79954,Genbank:NM_001261392.1,HGNC:HGNC:25862,MIM:616197 nucleolar protein 10 GO:0003723,GO:0005730 RNA binding|nucleolus NOL11 974.513718179631 1083.93913187173 865.088304487536 0.798096755667191 -0.325364435583225 0.037420697198301 0.744556882325193 15.7854 13.9996 12.7011 11.2762 GeneID:25926,Genbank:NM_015462.4,HGNC:HGNC:24557,MIM:615366 nucleolar protein 11 GO:0003723,GO:0005654,GO:0005730,GO:0006351,GO:0006364,GO:0030490,GO:0034455,GO:1901838 RNA binding|nucleoplasm|nucleolus|transcription, DNA-templated|rRNA processing|maturation of SSU-rRNA|t-UTP complex|positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter NOL12 391.579873199679 390.157360536978 393.00238586238 1.00729199449547 0.010481953401552 0.982224408122579 1 4.56067 4.99552 4.21349 5.10812 GeneID:79159,Genbank:NM_024313.2,HGNC:HGNC:28585 nucleolar protein 12 GO:0003723,GO:0005730,GO:0019843 RNA binding|nucleolus|rRNA binding NOL3 505.706861609466 492.89783315779 518.515890061141 1.05197437517472 0.0730995627494119 0.722581743876178 1 4.37932 5.30343 4.966 5.57771 GeneID:8996,Genbank:NM_001276312.1,HGNC:HGNC:7869,MIM:605235 nucleolar protein 3 NOL4 6.29080719622234 7.73528122683997 4.84633316560471 0.626523202387116 -0.67456015621175 0.614538226618451 1 0.0225939 0.0159411 0.0269617 0.0201095 GeneID:8715,Genbank:XM_017026055.2,HGNC:HGNC:7870,MIM:603577 nucleolar protein 4 GO:0003723,GO:0005730 RNA binding|nucleolus NOL4L 475.857147852618 513.594467897876 438.11982780736 0.853046236266075 -0.229304155191398 0.200889698974404 1 1.96892 1.76637 1.69291 1.4864 GeneID:140688,Genbank:NM_001256798.1,HGNC:HGNC:16106 nucleolar protein 4 like GO:0005654,GO:0005829 nucleoplasm|cytosol NOL6 3444.52200625672 3307.18398273298 3581.86002978047 1.08305435938296 0.115105654805991 0.409876723821844 1 21.503 22.8852 25.109 23.9344 GeneID:65083,Genbank:XM_017015044.2,HGNC:HGNC:19910,MIM:611532 nucleolar protein 6 GO:0000794,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005739,GO:0006364,GO:0006409,GO:0032040,GO:0032545,GO:0034456 condensed nuclear chromosome|RNA binding|nucleus|nucleoplasm|nucleolus|mitochondrion|rRNA processing|tRNA export from nucleus|small-subunit processome|CURI complex|UTP-C complex hsa03008 Ribosome biogenesis in eukaryotes NOL7 1645.65556865099 1717.71676310874 1573.59437419324 0.916096534649478 -0.126428463025893 0.375843649741122 1 35.8622 38.239 34.43 32.6061 GeneID:51406,Genbank:NM_001317724.1,HGNC:HGNC:21040,MIM:611533 nucleolar protein 7 GO:0003723,GO:0005634,GO:0005730,GO:0005739 RNA binding|nucleus|nucleolus|mitochondrion NOL8 187.672706995636 203.269702604408 172.075711386863 0.846538904628333 -0.240351722898034 0.487576131334227 1 0.86446 0.761444 0.847641 0.555857 GeneID:55035,Genbank:XM_011518824.3,HGNC:HGNC:23387,MIM:611534 nucleolar protein 8 GO:0003723,GO:0005730,GO:0006364,GO:1902570 RNA binding|nucleolus|rRNA processing|protein localization to nucleolus NOL9 586.903528917988 648.476722293172 525.330335542803 0.810098986568257 -0.303829892191442 0.0745535695163623 0.939457096281714 3.65057 3.33258 2.85446 2.84797 GeneID:79707,Genbank:NM_024654.4,HGNC:HGNC:26265 nucleolar protein 9 GO:0000448,GO:0000460,GO:0003723,GO:0005524,GO:0005654,GO:0005730,GO:0006364,GO:0016020,GO:0045111,GO:0051731 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA|RNA binding|ATP binding|nucleoplasm|nucleolus|rRNA processing|membrane|intermediate filament cytoskeleton|polynucleotide 5'-hydroxyl-kinase activity NOLC1 3216.45363123154 2625.50178161628 3807.40548084681 1.45016297741872 0.536215047482168 7.36604660089963e-05 0.0196624337266681 20.863 19.2686 31.6536 27.5635 GeneID:9221,Genbank:NM_001284389.1,HGNC:HGNC:15608,MIM:602394 nucleolar and coiled-body phosphoprotein 1 GO:0000278,GO:0001042,GO:0001650,GO:0003723,GO:0005524,GO:0005525,GO:0005730,GO:0005737,GO:0006364,GO:0006417,GO:0007000,GO:0007049,GO:0014029,GO:0014032,GO:0015030,GO:0046982 mitotic cell cycle|RNA polymerase I core binding|fibrillar center|RNA binding|ATP binding|GTP binding|nucleolus|cytoplasm|rRNA processing|regulation of translation|nucleolus organization|cell cycle|neural crest formation|neural crest cell development|Cajal body|protein heterodimerization activity NOM1 873.788738724551 929.552107949215 818.025369499886 0.880020993448791 -0.184390154338336 0.238050369224952 1 5.04473 5.16693 4.42525 4.48313 GeneID:64434,Genbank:NM_001353366.1,HGNC:HGNC:13244,MIM:611269 nucleolar protein with MIF4G domain 1 GO:0003723,GO:0005634,GO:0005730,GO:0022008,GO:0042274,GO:0048820 RNA binding|nucleus|nucleolus|neurogenesis|ribosomal small subunit biogenesis|hair follicle maturation NOMO1 3096.44309219175 3149.57513040316 3043.31105398033 0.966260821849573 -0.0495154279805033 0.702673647846429 1 24.5878 26.4883 23.9997 25.9159 GeneID:23420,Genbank:NM_014287.3,HGNC:HGNC:30060,MIM:609157 NODAL modulator 1 GO:0016020,GO:0016021,GO:0030246 membrane|integral component of membrane|carbohydrate binding NOMO2 1558.57037551778 1616.19961566783 1500.94113536773 0.92868549207489 -0.106737997576164 0.449291620821571 1 11.057 13.3023 12.0511 10.9089 GeneID:283820,Genbank:NM_001004060.1,HGNC:HGNC:22652,MIM:609158 NODAL modulator 2 GO:0005789,GO:0016021,GO:0030246,GO:0031648 endoplasmic reticulum membrane|integral component of membrane|carbohydrate binding|protein destabilization NOMO3 671.382237636266 668.176647921691 674.587827350841 1.00959503665549 0.0137767229111961 0.95656719942498 1 4.9757 5.46422 5.44115 5.45227 GeneID:408050,Genbank:NM_001004067.3,HGNC:HGNC:25242,MIM:609159 NODAL modulator 3 GO:0016021,GO:0030246 integral component of membrane|carbohydrate binding NONO 22169.1890919136 22363.1811133093 21975.1970705178 0.982650766864268 -0.0252493196582381 0.840790299696239 1 236.254 241.487 239.635 235.257 GeneID:4841,Genbank:NM_001145408.1,HGNC:HGNC:7871,MIM:300084 non-POU domain containing octamer binding GO:0001047,GO:0003723,GO:0005634,GO:0005730,GO:0006281,GO:0006310,GO:0006351,GO:0006397,GO:0007623,GO:0008380,GO:0016607,GO:0042752,GO:0045087,GO:0045892 core promoter binding|RNA binding|nucleus|nucleolus|DNA repair|DNA recombination|transcription, DNA-templated|mRNA processing|circadian rhythm|RNA splicing|nuclear speck|regulation of circadian rhythm|innate immune response|negative regulation of transcription, DNA-templated NOP10 3416.15795783136 3404.28169590202 3428.0342197607 1.00697724982256 0.0100310895622455 0.949985479452322 1 316.383 310.255 303.09 329.268 GeneID:55505,Genbank:NM_018648.3,HGNC:HGNC:14378,MIM:606471 NOP10 ribonucleoprotein GO:0000454,GO:0003723,GO:0005697,GO:0007004,GO:0016604,GO:0031118,GO:0031120,GO:0031429,GO:0034513,GO:0070034,GO:0072589,GO:0090661,GO:1904874 snoRNA guided rRNA pseudouridine synthesis|RNA binding|telomerase holoenzyme complex|telomere maintenance via telomerase|nuclear body|rRNA pseudouridine synthesis|snRNA pseudouridine synthesis|box H/ACA snoRNP complex|box H/ACA snoRNA binding|telomerase RNA binding|box H/ACA scaRNP complex|box H/ACA telomerase RNP complex|positive regulation of telomerase RNA localization to Cajal body hsa03008 Ribosome biogenesis in eukaryotes NOP14 2161.43427455031 2298.12362080623 2024.74492829439 0.881042651475844 -0.182716232854899 0.189386708501346 1 18.8353 18.9165 17.0996 16.709 GeneID:8602,Genbank:NM_001291979.1,HGNC:HGNC:16821,MIM:611526 NOP14 nucleolar protein GO:0000447,GO:0000462,GO:0000472,GO:0000480,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0016020,GO:0019899,GO:0030490,GO:0030515,GO:0030686,GO:0030692,GO:0032040,GO:0042274 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleoplasm|nucleolus|rRNA processing|membrane|enzyme binding|maturation of SSU-rRNA|snoRNA binding|90S preribosome|Noc4p-Nop14p complex|small-subunit processome|ribosomal small subunit biogenesis NOP16 1413.95659882066 1512.23683486797 1315.67636277335 0.870020047414213 -0.200879450280197 0.16522763028422 1 18.8928 19.5071 16.4907 18.1595 GeneID:51491,Genbank:NM_001291308.2,HGNC:HGNC:26934,MIM:612861 NOP16 nucleolar protein GO:0003723,GO:0005634,GO:0005730,GO:0042273,GO:0043231 RNA binding|nucleus|nucleolus|ribosomal large subunit biogenesis|intracellular membrane-bounded organelle NOP2 1556.14025135858 1658.90042022046 1453.38008249669 0.876110503548817 -0.190815246901697 0.180469066235881 1 13.0647 13.6055 11.5521 11.9448 GeneID:4839,Genbank:NM_006170.3,HGNC:HGNC:7867,MIM:164031 NOP2 nucleolar protein GO:0000027,GO:0000470,GO:0003723,GO:0005654,GO:0005730,GO:0006357,GO:0008284,GO:0009383,GO:0070475,GO:1901796 ribosomal large subunit assembly|maturation of LSU-rRNA|RNA binding|nucleoplasm|nucleolus|regulation of transcription from RNA polymerase II promoter|positive regulation of cell proliferation|rRNA (cytosine-C5-)-methyltransferase activity|rRNA base methylation|regulation of signal transduction by p53 class mediator NOP53 2107.62234259996 2096.56528078198 2118.67940441794 1.01054778682003 0.0151375455456455 0.933318288689506 1 60.877 63.32 61.1637 66.1544 GeneID:29997,Genbank:NM_015710.4,HGNC:HGNC:4333,MIM:605691 NOP53 ribosome biogenesis factor hsa05168 Herpes simplex infection NOP56 2952.5649483275 3211.26425811829 2693.86563853671 0.838880086472623 -0.253463495205959 0.061995892600322 0.889718831439746 45.1268 46.3991 38.0327 41.9403 GeneID:10528,Genbank:NM_006392.3,HGNC:HGNC:15911,MIM:614154 NOP56 ribonucleoprotein GO:0000154,GO:0001650,GO:0003723,GO:0005654,GO:0005730,GO:0005732,GO:0005737,GO:0006364,GO:0016020,GO:0030515,GO:0031428,GO:0032040,GO:0045296,GO:0070761,GO:1990226 rRNA modification|fibrillar center|RNA binding|nucleoplasm|nucleolus|small nucleolar ribonucleoprotein complex|cytoplasm|rRNA processing|membrane|snoRNA binding|box C/D snoRNP complex|small-subunit processome|cadherin binding|pre-snoRNP complex|histone methyltransferase binding hsa03008 Ribosome biogenesis in eukaryotes NOP58 585.056814781856 644.758064831361 525.355564732352 0.814810381425413 -0.295463733219364 0.0828730638452239 0.963076417285947 9.43038 8.99598 8.14527 7.00376 GeneID:51602,Genbank:NM_015934.4,HGNC:HGNC:29926,MIM:616742 NOP58 ribonucleoprotein GO:0000154,GO:0001094,GO:0001650,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005732,GO:0005829,GO:0006364,GO:0015030,GO:0016020,GO:0016049,GO:0030515,GO:0031428,GO:0032040,GO:0048254,GO:0051117,GO:0070761 rRNA modification|TFIID-class transcription factor binding|fibrillar center|RNA binding|nucleus|nucleoplasm|nucleolus|small nucleolar ribonucleoprotein complex|cytosol|rRNA processing|Cajal body|membrane|cell growth|snoRNA binding|box C/D snoRNP complex|small-subunit processome|snoRNA localization|ATPase binding|pre-snoRNP complex hsa03008 Ribosome biogenesis in eukaryotes NOP9 1961.09848548632 2020.08471611131 1902.11225486134 0.941600240668586 -0.086813405764901 0.54066472805358 1 13.426 13.2271 12.1906 12.7137 GeneID:161424,Genbank:NM_174913.2,HGNC:HGNC:19826 NOP9 nucleolar protein GO:0003723 RNA binding NOS1AP 48.1668485949951 40.1084027204949 56.2252944694953 1.40183329815737 0.487314798549053 0.256579104988092 1 0.165928 0.218305 0.28754 0.215763 GeneID:9722,Genbank:NM_014697.2,HGNC:HGNC:16859,MIM:605551 nitric oxide synthase 1 adaptor protein GO:0003062,GO:0005634,GO:0005739,GO:0005829,GO:0005901,GO:0010628,GO:0010750,GO:0030018,GO:0030315,GO:0033017,GO:0042981,GO:0045428,GO:0045429,GO:0048471,GO:0050998,GO:0050999,GO:0051000,GO:0060307,GO:0098901,GO:1901381,GO:1901841,GO:1902261,GO:1902514,GO:1903762,GO:2000170 regulation of heart rate by chemical signal|nucleus|mitochondrion|cytosol|caveola|positive regulation of gene expression|positive regulation of nitric oxide mediated signal transduction|Z disc|T-tubule|sarcoplasmic reticulum membrane|regulation of apoptotic process|regulation of nitric oxide biosynthetic process|positive regulation of nitric oxide biosynthetic process|perinuclear region of cytoplasm|nitric-oxide synthase binding|regulation of nitric-oxide synthase activity|positive regulation of nitric-oxide synthase activity|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of cardiac muscle cell action potential|positive regulation of potassium ion transmembrane transport|regulation of high voltage-gated calcium channel activity|positive regulation of delayed rectifier potassium channel activity|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|positive regulation of peptidyl-cysteine S-nitrosylation hsa04713 Circadian entrainment NOS2 3.18522335879267 2.00831188251439 4.36213483507094 2.17204054462377 1.11905103361267 0.595774687426003 1 0.00897781 0.023909 0.0251579 0.0156424 GeneID:4843,Genbank:NM_000625.4,HGNC:HGNC:7873,MIM:163730 nitric oxide synthase 2 hsa00220,hsa00330,hsa04020,hsa04066,hsa04146,hsa04371,hsa04926,hsa05132,hsa05133,hsa05140,hsa05142,hsa05145,hsa05146,hsa05152,hsa05200,hsa05222 Arginine biosynthesis|Arginine and proline metabolism|Calcium signaling pathway|HIF-1 signaling pathway|Peroxisome|Apelin signaling pathway|Relaxin signaling pathway|Salmonella infection|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Amoebiasis|Tuberculosis|Pathways in cancer|Small cell lung cancer NOSIP 1660.29413789599 1544.99620056081 1775.59207523116 1.14925336035561 0.200696884524332 0.225985489069203 1 15.7242 17.0676 18.8612 19.7134 GeneID:51070,Genbank:NM_001270960.1,HGNC:HGNC:17946,MIM:616759 nitric oxide synthase interacting protein GO:0000139,GO:0003723,GO:0005634,GO:0005737,GO:0005829,GO:0007275,GO:0016567,GO:0043086,GO:0050999,GO:0051001,GO:0061630 Golgi membrane|RNA binding|nucleus|cytoplasm|cytosol|multicellular organism development|protein ubiquitination|negative regulation of catalytic activity|regulation of nitric-oxide synthase activity|negative regulation of nitric-oxide synthase activity|ubiquitin protein ligase activity NOSTRIN 2.48750711367797 3.03648096111406 1.93853326624189 0.638414431398462 -0.647434830746163 0.834072962860468 1 0.00836357 0.00803169 0.0160744 0 GeneID:115677,Genbank:NM_001171631.1,HGNC:HGNC:20203,MIM:607496 nitric oxide synthase trafficking GO:0003677,GO:0005856,GO:0005886,GO:0006897,GO:0016607,GO:0030666,GO:0045892,GO:0050999 DNA binding|cytoskeleton|plasma membrane|endocytosis|nuclear speck|endocytic vesicle membrane|negative regulation of transcription, DNA-templated|regulation of nitric-oxide synthase activity NOTCH1 977.754543862305 905.261277261157 1050.24781046345 1.16015987521409 0.214323628874759 0.169255032928415 1 4.08075 4.11881 5.31421 4.39209 GeneID:4851,Genbank:NM_017617.4,HGNC:HGNC:7881,MIM:190198 notch 1 hsa01522,hsa04330,hsa04658,hsa04919,hsa05020,hsa05165,hsa05200,hsa05206,hsa05224 Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Thyroid hormone signaling pathway|Prion diseases|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Breast cancer NOTCH2 8083.65752688826 8111.24380573471 8056.0712480418 0.993198015123907 -0.00984671655198626 0.957342230335084 1 25.4338 25.9103 30.2578 21.4505 GeneID:4853,Genbank:NM_024408.3,HGNC:HGNC:7882,MIM:600275 notch 2 hsa01522,hsa04330,hsa04658,hsa04919,hsa05165,hsa05200,hsa05206,hsa05224 Endocrine resistance|Notch signaling pathway|Th1 and Th2 cell differentiation|Thyroid hormone signaling pathway|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Breast cancer NOTCH2NL 213.638639675245 224.708382776693 202.568896573797 0.901474587065591 -0.14964127281512 0.488640448073956 1 1.60475 2.04944 1.7093 1.68049 GeneID:388677,Genbank:NM_203458.4,HGNC:HGNC:31862 notch 2 N-terminal like GO:0005509,GO:0005576,GO:0005737,GO:0007219,GO:0007275,GO:0030154 calcium ion binding|extracellular region|cytoplasm|Notch signaling pathway|multicellular organism development|cell differentiation NOTCH3 10.8423513482514 11.9920363652935 9.69266633120943 0.808258583943365 -0.307111170609911 0.792630882802333 1 0.090446 0.0508054 0.0623254 0.0581827 GeneID:4854,Genbank:NM_000435.2,HGNC:HGNC:7883,MIM:600276 notch 3 hsa01522,hsa04330,hsa04371,hsa04658,hsa04919,hsa05165,hsa05200,hsa05206,hsa05224 Endocrine resistance|Notch signaling pathway|Apelin signaling pathway|Th1 and Th2 cell differentiation|Thyroid hormone signaling pathway|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Breast cancer NOTCH4 23.4765568171886 22.2355095317131 24.7176041026641 1.11162751037528 0.152673443673135 0.858523001245775 1 0.100269 0.110052 0.136503 0.15074 GeneID:4855,Genbank:NM_004557.3,HGNC:HGNC:7884,MIM:164951 notch 4 GO:0000139,GO:0001569,GO:0001709,GO:0001763,GO:0001886,GO:0004872,GO:0005509,GO:0005576,GO:0005634,GO:0005654,GO:0005789,GO:0005829,GO:0005886,GO:0005887,GO:0006367,GO:0007219,GO:0007220,GO:0007221,GO:0009790,GO:0009986,GO:0030097,GO:0030154,GO:0030879,GO:0045596,GO:0045602,GO:0045893,GO:0046982 Golgi membrane|branching involved in blood vessel morphogenesis|cell fate determination|morphogenesis of a branching structure|endothelial cell morphogenesis|receptor activity|calcium ion binding|extracellular region|nucleus|nucleoplasm|endoplasmic reticulum membrane|cytosol|plasma membrane|integral component of plasma membrane|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|Notch receptor processing|positive regulation of transcription of Notch receptor target|embryo development|cell surface|hemopoiesis|cell differentiation|mammary gland development|negative regulation of cell differentiation|negative regulation of endothelial cell differentiation|positive regulation of transcription, DNA-templated|protein heterodimerization activity hsa01522,hsa04330,hsa04919,hsa05165,hsa05200,hsa05206,hsa05224 Endocrine resistance|Notch signaling pathway|Thyroid hormone signaling pathway|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Breast cancer NOTUM 129.465449341531 141.176747381588 117.754151301474 0.834090269718391 -0.261724566579982 0.315073260568218 1 2.67564 3.08345 2.22062 2.39475 GeneID:147111,Genbank:NM_178493.5,HGNC:HGNC:27106,MIM:609847 notum, palmitoleoyl-protein carboxylesterase hsa04310 Wnt signaling pathway NOV 345.168632482017 302.599292721735 387.737972242299 1.28135782722683 0.357673413601436 0.0646675151269841 0.90091963811897 4.64289 5.05945 6.96401 5.50277 GeneID:4856,Genbank:NM_002514.3,HGNC:HGNC:7885,MIM:164958 nephroblastoma overexpressed GO:0001525,GO:0002062,GO:0005112,GO:0005178,GO:0005520,GO:0005576,GO:0005578,GO:0005615,GO:0005737,GO:0005921,GO:0007267,GO:0008083,GO:0008201,GO:0010468,GO:0010761,GO:0010832,GO:0014909,GO:0030308,GO:0030424,GO:0030425,GO:0033627,GO:0035767,GO:0042347,GO:0043025,GO:0043231,GO:0044342,GO:0045747,GO:0046676,GO:0048659,GO:0050728,GO:0060326,GO:0060392,GO:0060548,GO:0061484,GO:0071603,GO:0090027,GO:1902731,GO:1904057,GO:1990523 angiogenesis|chondrocyte differentiation|Notch binding|integrin binding|insulin-like growth factor binding|extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|gap junction|cell-cell signaling|growth factor activity|heparin binding|regulation of gene expression|fibroblast migration|negative regulation of myotube differentiation|smooth muscle cell migration|negative regulation of cell growth|axon|dendrite|cell adhesion mediated by integrin|endothelial cell chemotaxis|negative regulation of NF-kappaB import into nucleus|neuronal cell body|intracellular membrane-bounded organelle|type B pancreatic cell proliferation|positive regulation of Notch signaling pathway|negative regulation of insulin secretion|smooth muscle cell proliferation|negative regulation of inflammatory response|cell chemotaxis|negative regulation of SMAD protein import into nucleus|negative regulation of cell death|hematopoietic stem cell homeostasis|endothelial cell-cell adhesion|negative regulation of monocyte chemotaxis|negative regulation of chondrocyte proliferation|negative regulation of sensory perception of pain|bone regeneration NOVA1 102.480989964052 106.583591596463 98.3783883316422 0.923016262241505 -0.115572028545572 0.722345305685633 1 0.657192 0.58845 0.600406 0.492683 GeneID:4857,Genbank:NM_006489.2,HGNC:HGNC:7886,MIM:602157 NOVA alternative splicing regulator 1 GO:0000398,GO:0003729,GO:0005634,GO:0005730,GO:0043231,GO:0051252 mRNA splicing, via spliceosome|mRNA binding|nucleus|nucleolus|intracellular membrane-bounded organelle|regulation of RNA metabolic process NOVA2 183.03398147473 188.693039060381 177.374923889079 0.940018374669983 -0.0892391372607341 0.724773347847682 1 0.942523 0.832457 0.856138 0.825559 GeneID:4858,Genbank:NM_002516.3,HGNC:HGNC:7887,MIM:601991 NOVA alternative splicing regulator 2 GO:0000398,GO:0003723,GO:0005634,GO:0051252 mRNA splicing, via spliceosome|RNA binding|nucleus|regulation of RNA metabolic process NOX1 1.29721791692082 2.59443583384164 0 0 -Inf 0.298334034769393 1 0 0 0 0 GeneID:27035,Genbank:NM_001271815.1,HGNC:HGNC:7889,MIM:300225 NADPH oxidase 1 GO:0001525,GO:0003081,GO:0005769,GO:0005886,GO:0006739,GO:0006801,GO:0006954,GO:0007165,GO:0008217,GO:0008284,GO:0010575,GO:0015992,GO:0016021,GO:0016175,GO:0016477,GO:0030054,GO:0030171,GO:0030198,GO:0034765,GO:0042554,GO:0042743,GO:0043020,GO:0045726,GO:0045730,GO:0046330,GO:0046872,GO:0048365,GO:0048661,GO:0050661,GO:0051454,GO:0055114,GO:0071438,GO:0071455,GO:0072592,GO:1902177,GO:1990451 angiogenesis|regulation of systemic arterial blood pressure by renin-angiotensin|early endosome|plasma membrane|NADP metabolic process|superoxide metabolic process|inflammatory response|signal transduction|regulation of blood pressure|positive regulation of cell proliferation|positive regulation of vascular endothelial growth factor production|proton transport|integral component of membrane|superoxide-generating NADPH oxidase activity|cell migration|cell junction|voltage-gated proton channel activity|extracellular matrix organization|regulation of ion transmembrane transport|superoxide anion generation|hydrogen peroxide metabolic process|NADPH oxidase complex|positive regulation of integrin biosynthetic process|respiratory burst|positive regulation of JNK cascade|metal ion binding|Rac GTPase binding|positive regulation of smooth muscle cell proliferation|NADP binding|intracellular pH elevation|oxidation-reduction process|invadopodium membrane|cellular response to hyperoxia|oxygen metabolic process|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|cellular stress response to acidic pH hsa04380,hsa04933,hsa05418 Osteoclast differentiation|AGE-RAGE signaling pathway in diabetic complications|Fluid shear stress and atherosclerosis NOX4 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00783003 0 0 0 GeneID:50507,Genbank:NM_001143837.1,HGNC:HGNC:7891,MIM:605261 NADPH oxidase 4 GO:0000166,GO:0000902,GO:0001666,GO:0001725,GO:0005634,GO:0005730,GO:0005739,GO:0005789,GO:0005925,GO:0006801,GO:0006954,GO:0007569,GO:0008285,GO:0009055,GO:0010467,GO:0014911,GO:0016021,GO:0016174,GO:0016175,GO:0016324,GO:0019826,GO:0020037,GO:0034599,GO:0042554,GO:0043020,GO:0043065,GO:0043406,GO:0045453,GO:0048471,GO:0050660,GO:0050667,GO:0051496,GO:0051897,GO:0055007,GO:0055114,GO:0070374,GO:0071320,GO:0071333,GO:0071480,GO:0071560,GO:0072341,GO:0072593,GO:2000379,GO:2000573 nucleotide binding|cell morphogenesis|response to hypoxia|stress fiber|nucleus|nucleolus|mitochondrion|endoplasmic reticulum membrane|focal adhesion|superoxide metabolic process|inflammatory response|cell aging|negative regulation of cell proliferation|electron transfer activity|gene expression|positive regulation of smooth muscle cell migration|integral component of membrane|NAD(P)H oxidase activity|superoxide-generating NADPH oxidase activity|apical plasma membrane|oxygen sensor activity|heme binding|cellular response to oxidative stress|superoxide anion generation|NADPH oxidase complex|positive regulation of apoptotic process|positive regulation of MAP kinase activity|bone resorption|perinuclear region of cytoplasm|flavin adenine dinucleotide binding|homocysteine metabolic process|positive regulation of stress fiber assembly|positive regulation of protein kinase B signaling|cardiac muscle cell differentiation|oxidation-reduction process|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|cellular response to glucose stimulus|cellular response to gamma radiation|cellular response to transforming growth factor beta stimulus|modified amino acid binding|reactive oxygen species metabolic process|positive regulation of reactive oxygen species metabolic process|positive regulation of DNA biosynthetic process hsa04933 AGE-RAGE signaling pathway in diabetic complications NOXA1 35.0009633934673 31.2390912105775 38.7628355763571 1.24084389379523 0.311321626496831 0.535492943351143 1 0.200165 0.31579 0.160968 0.344266 GeneID:10811,Genbank:XM_011518158.3,HGNC:HGNC:10668,MIM:611255 NADPH oxidase activator 1 GO:0005829,GO:0006801,GO:0010310,GO:0016176,GO:0017124,GO:0019899,GO:0043020,GO:0048365,GO:0060263 cytosol|superoxide metabolic process|regulation of hydrogen peroxide metabolic process|superoxide-generating NADPH oxidase activator activity|SH3 domain binding|enzyme binding|NADPH oxidase complex|Rac GTPase binding|regulation of respiratory burst NOXO1 11.9455918348706 9.34957425676688 14.5416094129743 1.55532316377397 0.637214373497125 0.452755659518764 1 0.143577 0.0311432 0.166062 0.0155481 GeneID:124056,Genbank:XM_017022927.2,HGNC:HGNC:19404,MIM:611256 NADPH oxidase organizer 1 GO:0005543,GO:0005622,GO:0005886,GO:0006801,GO:0010310,GO:0016176,GO:0019899,GO:0022617,GO:0035091,GO:0042802,GO:0043020,GO:0055114,GO:0060263 phospholipid binding|intracellular|plasma membrane|superoxide metabolic process|regulation of hydrogen peroxide metabolic process|superoxide-generating NADPH oxidase activator activity|enzyme binding|extracellular matrix disassembly|phosphatidylinositol binding|identical protein binding|NADPH oxidase complex|oxidation-reduction process|regulation of respiratory burst NOXRED1 1.96591792532285 0.538097676642304 3.3937381740034 6.30691846725693 2.65693528287698 0.354915179602142 1 0 0 0.0432353 0.0268181 GeneID:122945,Genbank:NM_001113475.2,HGNC:HGNC:20487 NADP dependent oxidoreductase domain containing 1 GO:0016491 oxidoreductase activity NPAS1 116.991223572743 108.45763331003 125.524813835456 1.15736264940097 0.210840991078869 0.465711832190605 1 1.14265 0.772228 1.46248 1.05102 GeneID:4861,Genbank:NM_002517.3,HGNC:HGNC:7894,MIM:603346 neuronal PAS domain protein 1 GO:0000122,GO:0000981,GO:0001964,GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006357,GO:0007417,GO:0042711,GO:0046983 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|startle response|DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|central nervous system development|maternal behavior|protein dimerization activity NPAS2 150.676561791848 151.112445589682 150.240677994013 0.994231000681202 -0.00834700686357122 0.965800997724443 1 0.530976 0.591365 0.580432 0.528691 GeneID:4862,Genbank:NM_002518.3,HGNC:HGNC:7895,MIM:603347 neuronal PAS domain protein 2 GO:0001047,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006351,GO:0006974,GO:0007417,GO:0007623,GO:0019216,GO:0032922,GO:0045739,GO:0045893,GO:0045944,GO:0046872,GO:0046983,GO:0051775,GO:0051879,GO:0060548,GO:2001020 core promoter binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|cytosol|transcription, DNA-templated|cellular response to DNA damage stimulus|central nervous system development|circadian rhythm|regulation of lipid metabolic process|circadian regulation of gene expression|positive regulation of DNA repair|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|protein dimerization activity|response to redox state|Hsp90 protein binding|negative regulation of cell death|regulation of response to DNA damage stimulus hsa04710 Circadian rhythm NPAS3 130.633624441384 131.365510687333 129.901738195434 0.9888572542044 -0.0161658181039561 0.968579219493008 1 0.414559 0.436702 0.527949 0.310403 GeneID:64067,Genbank:XM_017021582.1,HGNC:HGNC:19311,MIM:609430 neuronal PAS domain protein 3 GO:0000981,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006357,GO:0032502,GO:0045893,GO:0046983 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|developmental process|positive regulation of transcription, DNA-templated|protein dimerization activity NPAS4 2.05046508577574 3.13253351048394 0.968396661067546 0.309141676482158 -1.69365993276169 0.550222127666681 1 0.0331612 0.0146741 0 0.00724145 GeneID:266743,Genbank:XM_017017537.1,HGNC:HGNC:18983,MIM:608554 neuronal PAS domain protein 4 GO:0000978,GO:0000981,GO:0001077,GO:0005634,GO:0005667,GO:0007612,GO:0007614,GO:0007616,GO:0030154,GO:0032228,GO:0035176,GO:0045944,GO:0046982,GO:0048167,GO:0060079,GO:0060080,GO:0071386,GO:0098794,GO:1904862 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|transcription factor complex|learning|short-term memory|long-term memory|cell differentiation|regulation of synaptic transmission, GABAergic|social behavior|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|regulation of synaptic plasticity|excitatory postsynaptic potential|inhibitory postsynaptic potential|cellular response to corticosterone stimulus|postsynapse|inhibitory synapse assembly NPAT 70.7385813932906 72.6540120026738 68.8231507839073 0.947272544032042 -0.0781485252088482 0.855865705693994 1 0.317046 0.293561 0.333295 0.251078 GeneID:4863,Genbank:XM_011542854.2,HGNC:HGNC:7896,MIM:601448 nuclear protein, coactivator of histone transcription GO:0000083,GO:0003713,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0008022,GO:0010468,GO:0015030,GO:0045893,GO:0047485,GO:0097504 regulation of transcription involved in G1/S transition of mitotic cell cycle|transcription coactivator activity|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|protein C-terminus binding|regulation of gene expression|Cajal body|positive regulation of transcription, DNA-templated|protein N-terminus binding|Gemini of coiled bodies NPB 12.9344358794456 13.2701454724258 12.5987262864655 0.949403781039517 -0.0749062995163743 0.971458646318509 1 1.11936 0.905236 0.676248 1.26099 GeneID:256933,Genbank:NM_148896.4,HGNC:HGNC:30099,MIM:607996 neuropeptide B GO:0001664,GO:0005576,GO:0007186,GO:0007218 G-protein coupled receptor binding|extracellular region|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway hsa04080 Neuroactive ligand-receptor interaction NPC1 1244.59391373828 1190.35226968137 1298.83555779518 1.09113544862047 0.125830202416632 0.402260713035578 1 5.49882 5.78976 6.50706 5.89204 GeneID:4864,Genbank:XM_005258277.1,HGNC:HGNC:7897,MIM:607623 NPC intracellular cholesterol transporter 1 GO:0001618,GO:0004872,GO:0004888,GO:0005576,GO:0005635,GO:0005764,GO:0005765,GO:0005783,GO:0005794,GO:0005887,GO:0006486,GO:0006897,GO:0006914,GO:0007041,GO:0007628,GO:0008203,GO:0008206,GO:0015248,GO:0015485,GO:0016020,GO:0016021,GO:0016242,GO:0030301,GO:0031579,GO:0031902,GO:0033344,GO:0034383,GO:0042493,GO:0042632,GO:0045121,GO:0046686,GO:0046718,GO:0048471,GO:0060548,GO:0070062,GO:0071383,GO:0071404,GO:0090150,GO:2000189 virus receptor activity|receptor activity|transmembrane signaling receptor activity|extracellular region|nuclear envelope|lysosome|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|integral component of plasma membrane|protein glycosylation|endocytosis|autophagy|lysosomal transport|adult walking behavior|cholesterol metabolic process|bile acid metabolic process|sterol transporter activity|cholesterol binding|membrane|integral component of membrane|negative regulation of macroautophagy|cholesterol transport|membrane raft organization|late endosome membrane|cholesterol efflux|low-density lipoprotein particle clearance|response to drug|cholesterol homeostasis|membrane raft|response to cadmium ion|viral entry into host cell|perinuclear region of cytoplasm|negative regulation of cell death|extracellular exosome|cellular response to steroid hormone stimulus|cellular response to low-density lipoprotein particle stimulus|establishment of protein localization to membrane|positive regulation of cholesterol homeostasis hsa04142,hsa04979 Lysosome|Cholesterol metabolism NPC1L1 1.4593380350783 0.980142803914724 1.93853326624189 1.97780696700452 0.983901626635446 0.869495943289778 1 0 0.0167051 0.0178226 0.0083316 GeneID:29881,Genbank:XM_011515326.3,HGNC:HGNC:7898,MIM:608010 NPC1 like intracellular cholesterol transporter 1 GO:0005886,GO:0006695,GO:0008144,GO:0016324,GO:0017137,GO:0030299,GO:0030301,GO:0030659,GO:0031489,GO:0031526,GO:0042157,GO:0042493,GO:0044214,GO:0071501,GO:0098856 plasma membrane|cholesterol biosynthetic process|drug binding|apical plasma membrane|Rab GTPase binding|intestinal cholesterol absorption|cholesterol transport|cytoplasmic vesicle membrane|myosin V binding|brush border membrane|lipoprotein metabolic process|response to drug|spanning component of plasma membrane|cellular response to sterol depletion|intestinal lipid absorption hsa04975 Fat digestion and absorption NPC2 5567.33296365139 5279.2308757965 5855.43505150628 1.10914547767772 0.149448604597437 0.260416864233419 1 127.797 133.426 142.591 151.744 GeneID:10577,Genbank:NM_006432.3,HGNC:HGNC:14537,MIM:601015 NPC intracellular cholesterol transporter 2 GO:0005576,GO:0005764,GO:0005783,GO:0008203,GO:0009615,GO:0015485,GO:0015914,GO:0017127,GO:0019747,GO:0019899,GO:0030301,GO:0032366,GO:0032367,GO:0033344,GO:0034383,GO:0035578,GO:0042632,GO:0043202,GO:0043312,GO:0046836,GO:0070062 extracellular region|lysosome|endoplasmic reticulum|cholesterol metabolic process|response to virus|cholesterol binding|phospholipid transport|cholesterol transporter activity|regulation of isoprenoid metabolic process|enzyme binding|cholesterol transport|intracellular sterol transport|intracellular cholesterol transport|cholesterol efflux|low-density lipoprotein particle clearance|azurophil granule lumen|cholesterol homeostasis|lysosomal lumen|neutrophil degranulation|glycolipid transport|extracellular exosome hsa04142,hsa04979 Lysosome|Cholesterol metabolism NPDC1 731.824992854242 696.503719684993 767.146266023491 1.10142450692216 0.139370614220385 0.392352422543329 1 21.5248 20.3978 23.5692 24.2756 GeneID:56654,Genbank:NM_015392.3,HGNC:HGNC:7899,MIM:605798 neural proliferation, differentiation and control 1 GO:0005886,GO:0016021,GO:0050776 plasma membrane|integral component of membrane|regulation of immune response NPEPL1 921.831138797666 834.70182103526 1008.96045656007 1.20876752767675 0.273536809585456 0.0806845196972107 0.951623427935096 14.8326 14.7331 17.9869 18.3834 GeneID:79716,Genbank:NM_001204872.1,HGNC:HGNC:16244 aminopeptidase like 1 GO:0004177,GO:0005634,GO:0005737,GO:0008235,GO:0030145 aminopeptidase activity|nucleus|cytoplasm|metalloexopeptidase activity|manganese ion binding NPEPPS 2736.36218255232 2742.25241114 2730.47195396463 0.995704094514599 -0.00621103211590608 0.979557586788269 1 20.9966 20.2949 22.1998 19.7198 GeneID:9520,Genbank:XM_017025373.1,HGNC:HGNC:7900,MIM:606793 aminopeptidase puromycin sensitive GO:0000209,GO:0004177,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008270,GO:0042277,GO:0043171,GO:0070006,GO:0070062,GO:0071456,GO:1903955 protein polyubiquitination|aminopeptidase activity|nucleus|cytoplasm|cytosol|proteolysis|zinc ion binding|peptide binding|peptide catabolic process|metalloaminopeptidase activity|extracellular exosome|cellular response to hypoxia|positive regulation of protein targeting to mitochondrion NPFF 11.6460275696602 12.1459238444562 11.1461312948641 0.917684931801345 -0.123929175832744 0.916759909649067 1 0.473893 0.362041 0.377107 0.117718 GeneID:8620,Genbank:XM_024449248.1,HGNC:HGNC:7901,MIM:604643 neuropeptide FF-amide peptide precursor GO:0001664,GO:0002438,GO:0003254,GO:0005102,GO:0005184,GO:0005576,GO:0005615,GO:0007186,GO:0007204,GO:0007218,GO:0007268,GO:0010459,GO:0021510,GO:0030103,GO:0030425,GO:0031982,GO:0032099,GO:0043204,GO:0043278,GO:0043679,GO:0045777,GO:0046676,GO:0051930,GO:0060079,GO:0060135,GO:0070253,GO:0098794 G-protein coupled receptor binding|acute inflammatory response to antigenic stimulus|regulation of membrane depolarization|receptor binding|neuropeptide hormone activity|extracellular region|extracellular space|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|chemical synaptic transmission|negative regulation of heart rate|spinal cord development|vasopressin secretion|dendrite|vesicle|negative regulation of appetite|perikaryon|response to morphine|axon terminus|positive regulation of blood pressure|negative regulation of insulin secretion|regulation of sensory perception of pain|excitatory postsynaptic potential|maternal process involved in female pregnancy|somatostatin secretion|postsynapse hsa04080 Neuroactive ligand-receptor interaction NPFFR1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0541111 0 0 GeneID:64106,Genbank:NM_022146.4,HGNC:HGNC:17425,MIM:607448 neuropeptide FF receptor 1 GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0008188,GO:0032870,GO:0042277,GO:1901652 G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|neuropeptide receptor activity|cellular response to hormone stimulus|peptide binding|response to peptide hsa04080 Neuroactive ligand-receptor interaction NPHP1 60.5316963439166 62.43015614647 58.6332365413632 0.939181321344148 -0.0905243788075154 0.820641719957067 1 0.417719 0.433304 0.390573 0.41609 GeneID:4867,Genbank:NM_001128179.1,HGNC:HGNC:7905,MIM:607100 nephrocystin 1 GO:0005198,GO:0005829,GO:0005856,GO:0005911,GO:0005912,GO:0005923,GO:0007165,GO:0007588,GO:0007632,GO:0016020,GO:0030030,GO:0030036,GO:0031514,GO:0032391,GO:0048515,GO:0060041,GO:0097711,GO:0098609,GO:1903348 structural molecule activity|cytosol|cytoskeleton|cell-cell junction|adherens junction|bicellular tight junction|signal transduction|excretion|visual behavior|membrane|cell projection organization|actin cytoskeleton organization|motile cilium|photoreceptor connecting cilium|spermatid differentiation|retina development in camera-type eye|ciliary basal body-plasma membrane docking|cell-cell adhesion|positive regulation of bicellular tight junction assembly NPHP3 107.386515267513 98.9443629189927 115.828667616033 1.17064443288056 0.22730294363028 0.424785905491127 1 0.694868 0.619055 0.738637 0.707999 GeneID:27031,Genbank:NM_153240.4,HGNC:HGNC:7907,MIM:608002 nephrocystin 3 GO:0001822,GO:0001947,GO:0003283,GO:0005829,GO:0005929,GO:0006629,GO:0007163,GO:0007368,GO:0016055,GO:0030198,GO:0030324,GO:0030814,GO:0035469,GO:0045494,GO:0048496,GO:0060027,GO:0060271,GO:0060287,GO:0060993,GO:0071908,GO:0071909,GO:0071910,GO:0072189,GO:0090090,GO:0097543,GO:0097546,GO:1905515,GO:2000095,GO:2000167 kidney development|heart looping|atrial septum development|cytosol|cilium|lipid metabolic process|establishment or maintenance of cell polarity|determination of left/right symmetry|Wnt signaling pathway|extracellular matrix organization|lung development|regulation of cAMP metabolic process|determination of pancreatic left/right asymmetry|photoreceptor cell maintenance|maintenance of animal organ identity|convergent extension involved in gastrulation|cilium assembly|epithelial cilium movement involved in determination of left/right asymmetry|kidney morphogenesis|determination of intestine left/right asymmetry|determination of stomach left/right asymmetry|determination of liver left/right asymmetry|ureter development|negative regulation of canonical Wnt signaling pathway|ciliary inversin compartment|ciliary base|non-motile cilium assembly|regulation of Wnt signaling pathway, planar cell polarity pathway|regulation of planar cell polarity pathway involved in neural tube closure NPHP4 315.671766662171 307.605867945787 323.737665378555 1.0524430744462 0.0737422015242693 0.736619904213875 1 1.16645 1.29748 1.41648 1.30975 GeneID:261734,Genbank:NM_001291594.1,HGNC:HGNC:19104,MIM:607215 nephrocystin 4 GO:0005198,GO:0005634,GO:0005813,GO:0005829,GO:0005911,GO:0005923,GO:0007165,GO:0007632,GO:0030036,GO:0030317,GO:0032391,GO:0035329,GO:0035845,GO:0036064,GO:0045494,GO:0060041,GO:0090090,GO:0097470,GO:0097546,GO:0097711,GO:0098609,GO:1903348 structural molecule activity|nucleus|centrosome|cytosol|cell-cell junction|bicellular tight junction|signal transduction|visual behavior|actin cytoskeleton organization|flagellated sperm motility|photoreceptor connecting cilium|hippo signaling|photoreceptor cell outer segment organization|ciliary basal body|photoreceptor cell maintenance|retina development in camera-type eye|negative regulation of canonical Wnt signaling pathway|ribbon synapse|ciliary base|ciliary basal body-plasma membrane docking|cell-cell adhesion|positive regulation of bicellular tight junction assembly NPIPA1 68.4861311143668 79.7933606230786 57.1789016056551 0.716587209251057 -0.480785802545465 0.262995069736857 1 2.36316 1.47316 1.21747 1.55048 GeneID:9284,Genbank:NM_006985.3,HGNC:HGNC:7909,MIM:606406 nuclear pore complex interacting protein family member A1 GO:0005643,GO:0005654,GO:0015031,GO:0031965,GO:0051028 nuclear pore|nucleoplasm|protein transport|nuclear membrane|mRNA transport NPIPA2 3.42851911566455 2.49838328447175 4.35865494685735 1.74459018115746 0.802888175087998 0.740535422102725 1 0 0.00735262 0 0.00693028 GeneID:642799,Genbank:XM_024450381.1,HGNC:HGNC:41979 nuclear pore complex interacting protein family member A2 GO:0005654 nucleoplasm NPIPA3 1.21386734807293 0.490071401957362 1.93766329418849 3.95383873951713 1.98325403079315 0.683591311517638 1 0.0144329 0 0 0.0128549 GeneID:642778,Genbank:XM_017023553.1,HGNC:HGNC:41978 nuclear pore complex interacting protein family member A3 GO:0005654 nucleoplasm NPIPA5 40.7948831848287 45.7295108603427 35.8602555093147 0.784181917423771 -0.35073971998495 0.445735626215399 1 0.536411 0.518052 0.400678 0.423335 GeneID:100288332,Genbank:XM_024450132.1,HGNC:HGNC:41980 nuclear pore complex interacting protein family member A5 GO:0005654 nucleoplasm NPIPA7 18.661694916148 15.0285173264075 22.2948725058885 1.48350446166188 0.569009265751645 0.389375143267095 1 0.048383 0.0299806 0.122478 0.0142665 GeneID:101059938,Genbank:XM_017022835.1,HGNC:HGNC:41982 nuclear pore complex interacting protein family member A7 GO:0005654 nucleoplasm NPIPA8 30.5675156161821 25.7424445845687 35.3925866477955 1.37487279156897 0.459298141210052 0.640410038233765 1 0.346479 0.0166597 0.239572 0.111832 GeneID:101059953,Genbank:NM_001349948.1,HGNC:HGNC:41983 nuclear pore complex interacting protein family member A8 GO:0005654 nucleoplasm NPIPB11 7.83012427841005 10.3297170606816 5.33053149613849 0.516038480514466 -0.954449444786384 0.388755582308681 1 0.0857757 0.0565979 0.0364804 0.0410753 GeneID:728888,Genbank:NM_001310137.1,HGNC:HGNC:37453 nuclear pore complex interacting protein family member B11 GO:0005654,GO:0016021 nucleoplasm|integral component of membrane NPIPB12 6.0171902445577 6.21704074628294 5.81733974283245 0.935708801057889 -0.0958684717385733 1 1 0.108286 0.0721661 0.0874792 0.0821602 GeneID:440353,Genbank:NM_001355401.1,HGNC:HGNC:37491 nuclear pore complex interacting protein family, member B12 GO:0005654,GO:0016021 nucleoplasm|integral component of membrane NPIPB13 4.7013972756913 4.55472144167109 4.84807310971151 1.06440606122617 0.0900486308767932 1 1 0.021103 0.0469736 0.0293472 0 GeneID:613037,Genbank:NM_001321892.1,HGNC:HGNC:41989 nuclear pore complex interacting protein family, member B13 GO:0005654,GO:0016021 nucleoplasm|integral component of membrane NPIPB15 10.0123882875505 10.819788462639 9.20498811246207 0.850754905629361 -0.233184529794055 0.856659240733923 1 0.117784 0.0696717 0.0611715 0.114011 GeneID:440348,Genbank:XM_011523496.2,HGNC:HGNC:34409 nuclear pore complex interacting protein family member B15 GO:0005576,GO:0005654 extracellular region|nucleoplasm NPIPB2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:729978,Genbank:XM_024450428.1,HGNC:HGNC:37451 nuclear pore complex interacting protein family, member B2 GO:0005654 nucleoplasm NPIPB3 27.7764305912372 24.5319790623372 31.0208821201372 1.26450793233238 0.338576087140092 0.554503053825239 1 0.313981 0.288714 0.321598 0.282286 GeneID:23117,Genbank:NM_130464.3,HGNC:HGNC:28989 nuclear pore complex interacting protein family member B3 GO:0005654,GO:0016021 nucleoplasm|integral component of membrane NPIPB4 16.857040043124 17.719005709619 15.9950743766291 0.902707219510961 -0.14766994931947 0.901477411605107 1 0.202629 0.119822 0.110861 0.0856318 GeneID:440345,Genbank:NM_001310148.1,HGNC:HGNC:41985 nuclear pore complex interacting protein family member B4 GO:0005654,GO:0016021 nucleoplasm|integral component of membrane NPIPB5 149.765223473699 135.218438318091 164.312008629308 1.21515978643961 0.281146032306063 0.320926153904034 1 0.71946 0.709563 1.24872 0.931122 GeneID:100132247,Genbank:NM_001135865.1,HGNC:HGNC:37233 nuclear pore complex interacting protein family member B5 GO:0005654,GO:0016021 nucleoplasm|integral component of membrane NPIPB6 1.5393170821877 2.59443583384164 0.484198330533773 0.186629526241476 -2.42175084507305 0.49977085294748 1 0.014241 0.013093 0 0 GeneID:728741,Genbank:NM_001282524.1,HGNC:HGNC:37454 nuclear pore complex interacting protein family member B6 GO:0005654 nucleoplasm NPIPB8 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0 0 0 0 GeneID:728734,Genbank:XM_024450415.1,HGNC:HGNC:37490 nuclear pore complex interacting protein family member B8 GO:0005654 nucleoplasm NPIPB9 1.02566752891457 1.56626675524197 0.48506830258717 0.309697119576692 -1.69107012999473 0.789536483244536 1 0.0179039 0.00831413 0 0 GeneID:100507607,Genbank:XM_017022815.2,HGNC:HGNC:41987 nuclear pore complex interacting protein family member B9 GO:0005654 nucleoplasm NPL 39.6750972827475 39.6085226634296 39.7416719020655 1.0033616310249 0.00484167499830191 1 1 0.504016 0.403808 0.525443 0.409054 GeneID:80896,Genbank:NM_030769.2,HGNC:HGNC:16781,MIM:611412 N-acetylneuraminate pyruvate lyase GO:0005829,GO:0005975,GO:0008747,GO:0019262,GO:0042802 cytosol|carbohydrate metabolic process|N-acetylneuraminate lyase activity|N-acetylneuraminate catabolic process|identical protein binding hsa00520 Amino sugar and nucleotide sugar metabolism NPLOC4 6797.8300892038 6605.40056740497 6990.25961100263 1.05826430050235 0.0816999841672452 0.546496650185595 1 51.7888 54.4099 58.6761 56.777 GeneID:55666,Genbank:NM_017921.3,HGNC:HGNC:18261,MIM:606590 NPL4 homolog, ubiquitin recognition factor GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0006511,GO:0007030,GO:0030433,GO:0030970,GO:0031625,GO:0032480,GO:0034098,GO:0036501,GO:0039536,GO:0042175,GO:0043130,GO:0046872,GO:0070987 nucleus|nucleoplasm|endoplasmic reticulum|cytosol|ubiquitin-dependent protein catabolic process|Golgi organization|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|ubiquitin protein ligase binding|negative regulation of type I interferon production|VCP-NPL4-UFD1 AAA ATPase complex|UFD1-NPL4 complex|negative regulation of RIG-I signaling pathway|nuclear outer membrane-endoplasmic reticulum membrane network|ubiquitin binding|metal ion binding|error-free translesion synthesis hsa04141 Protein processing in endoplasmic reticulum NPM1 18352.4844001692 20289.5869241326 16415.3818762059 0.809054513410584 -0.305691181382302 0.0186280913095176 0.557658897968661 350.423 342.655 282.686 281.95 GeneID:4869,Genbank:NM_001355006.1,HGNC:HGNC:7910,MIM:164040 nucleophosmin 1 GO:0003723,GO:0004860,GO:0005654,GO:0005730,GO:0005737,GO:0005815,GO:0006281,GO:0008284,GO:0032071,GO:0043066,GO:0044387,GO:0045727,GO:0045893,GO:0045944,GO:0046599,GO:0060699,GO:0060735,GO:1902751 RNA binding|protein kinase inhibitor activity|nucleoplasm|nucleolus|cytoplasm|microtubule organizing center|DNA repair|positive regulation of cell proliferation|regulation of endodeoxyribonuclease activity|negative regulation of apoptotic process|negative regulation of protein kinase activity by regulation of protein phosphorylation|positive regulation of translation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of centriole replication|regulation of endoribonuclease activity|regulation of eIF2 alpha phosphorylation by dsRNA|positive regulation of cell cycle G2/M phase transition NPM2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:10361,Genbank:XM_017012947.1,HGNC:HGNC:7930,MIM:608073 nucleophosmin/nucleoplasmin 2 GO:0000789,GO:0000790,GO:0003682,GO:0005634,GO:0006338,GO:0007096,GO:0007338,GO:0009790,GO:0009994,GO:0016569,GO:0019899,GO:0042393,GO:0043085,GO:0045740,GO:0045836,GO:0051260 cytoplasmic chromatin|nuclear chromatin|chromatin binding|nucleus|chromatin remodeling|regulation of exit from mitosis|single fertilization|embryo development|oocyte differentiation|covalent chromatin modification|enzyme binding|histone binding|positive regulation of catalytic activity|positive regulation of DNA replication|positive regulation of meiotic nuclear division|protein homooligomerization NPM3 699.599524009882 732.413202196828 666.785845822937 0.910395721735974 -0.135434316949366 0.430888951686344 1 34.4913 37.128 30.1978 34.9847 GeneID:10360,Genbank:NM_006993.2,HGNC:HGNC:7931,MIM:606456 nucleophosmin/nucleoplasmin 3 GO:0003723,GO:0005730,GO:0005829,GO:0006364,GO:0009303,GO:0015629 RNA binding|nucleolus|cytosol|rRNA processing|rRNA transcription|actin cytoskeleton NPNT 15.7537007846887 19.3911336693388 12.1162679000385 0.624835458650706 -0.678451767899176 0.351370705893497 1 0.1208 0.162781 0.0993138 0.0847845 GeneID:255743,Genbank:NM_001184690.1,HGNC:HGNC:27405,MIM:610306 nephronectin GO:0001657,GO:0001658,GO:0005178,GO:0005509,GO:0005576,GO:0005578,GO:0005604,GO:0007160,GO:0010694,GO:0010811,GO:0030198,GO:0030485,GO:0030511,GO:0033631,GO:0034678,GO:0045184,GO:0045669,GO:0045987,GO:0070062,GO:0070374,GO:0071356,GO:0097195,GO:2000721 ureteric bud development|branching involved in ureteric bud morphogenesis|integrin binding|calcium ion binding|extracellular region|proteinaceous extracellular matrix|basement membrane|cell-matrix adhesion|positive regulation of alkaline phosphatase activity|positive regulation of cell-substrate adhesion|extracellular matrix organization|smooth muscle contractile fiber|positive regulation of transforming growth factor beta receptor signaling pathway|cell-cell adhesion mediated by integrin|integrin alpha8-beta1 complex|establishment of protein localization|positive regulation of osteoblast differentiation|positive regulation of smooth muscle contraction|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to tumor necrosis factor|pilomotor reflex|positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation NPPA 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0 0 0 GeneID:4878,Genbank:NM_006172.3,HGNC:HGNC:7939,MIM:108780 natriuretic peptide A hsa04066,hsa04270 HIF-1 signaling pathway|Vascular smooth muscle contraction NPPB 1.24625510652408 2.00831188251439 0.484198330533773 0.241097179551395 -2.05231332105607 0.634444149061074 1 0 0.252112 0 0 GeneID:4879,Genbank:NM_002521.2,HGNC:HGNC:7940,MIM:600295 natriuretic peptide B hsa04022,hsa04270 cGMP-PKG signaling pathway|Vascular smooth muscle contraction NPPC 0.99578132014851 0.538097676642304 1.45346496365472 2.70111733751434 1.43355631240266 0.835241087836065 1 0.0156892 0 0 0.0138023 GeneID:4880,Genbank:NM_024409.3,HGNC:HGNC:7941,MIM:600296 natriuretic peptide C GO:0001503,GO:0001666,GO:0003418,GO:0003419,GO:0005102,GO:0005179,GO:0005576,GO:0005615,GO:0006182,GO:0006457,GO:0007168,GO:0008285,GO:0009791,GO:0022414,GO:0030141,GO:0030814,GO:0030823,GO:0030828,GO:0040014,GO:0042803,GO:0043234,GO:0045471,GO:0045669,GO:0048660,GO:0051053,GO:0051427,GO:0051428,GO:0051447,GO:0097755,GO:1900194,GO:1903779 ossification|response to hypoxia|growth plate cartilage chondrocyte differentiation|growth plate cartilage chondrocyte proliferation|receptor binding|hormone activity|extracellular region|extracellular space|cGMP biosynthetic process|protein folding|receptor guanylyl cyclase signaling pathway|negative regulation of cell proliferation|post-embryonic development|reproductive process|secretory granule|regulation of cAMP metabolic process|regulation of cGMP metabolic process|positive regulation of cGMP biosynthetic process|regulation of multicellular organism growth|protein homodimerization activity|protein complex|response to ethanol|positive regulation of osteoblast differentiation|regulation of smooth muscle cell proliferation|negative regulation of DNA metabolic process|hormone receptor binding|peptide hormone receptor binding|negative regulation of meiotic cell cycle|positive regulation of blood vessel diameter|negative regulation of oocyte maturation|regulation of cardiac conduction hsa04270,hsa05418 Vascular smooth muscle contraction|Fluid shear stress and atherosclerosis NPR1 2.21889326138352 2.49838328447175 1.93940323829528 0.776263294086737 -0.365382024116205 0.964462981754576 1 0.0112496 0.0394202 0.0314096 0 GeneID:4881,Genbank:XM_005245218.2,HGNC:HGNC:7943,MIM:108960 natriuretic peptide receptor 1 GO:0004383,GO:0004672,GO:0005524,GO:0005525,GO:0005886,GO:0006182,GO:0007166,GO:0007168,GO:0007589,GO:0008074,GO:0008217,GO:0008528,GO:0016021,GO:0016525,GO:0016941,GO:0017046,GO:0019901,GO:0030308,GO:0030828,GO:0035556,GO:0035810,GO:0035815,GO:0042417,GO:0042562,GO:0043114,GO:0043235,GO:0048662,GO:0097746,GO:1903779 guanylate cyclase activity|protein kinase activity|ATP binding|GTP binding|plasma membrane|cGMP biosynthetic process|cell surface receptor signaling pathway|receptor guanylyl cyclase signaling pathway|body fluid secretion|guanylate cyclase complex, soluble|regulation of blood pressure|G-protein coupled peptide receptor activity|integral component of membrane|negative regulation of angiogenesis|natriuretic peptide receptor activity|peptide hormone binding|protein kinase binding|negative regulation of cell growth|positive regulation of cGMP biosynthetic process|intracellular signal transduction|positive regulation of urine volume|positive regulation of renal sodium excretion|dopamine metabolic process|hormone binding|regulation of vascular permeability|receptor complex|negative regulation of smooth muscle cell proliferation|regulation of blood vessel diameter|regulation of cardiac conduction hsa00230,hsa04022,hsa04024,hsa04270,hsa04714,hsa04921,hsa04923,hsa04924,hsa04925 Purine metabolism|cGMP-PKG signaling pathway|cAMP signaling pathway|Vascular smooth muscle contraction|Thermogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion NPR2 108.081449865224 105.661283722341 110.501616008108 1.04580989474334 0.0646206251631608 0.83873673098699 1 0.483041 0.50082 0.469382 0.444858 GeneID:4882,Genbank:XM_024447558.1,HGNC:HGNC:7944,MIM:108961 natriuretic peptide receptor 2 GO:0001503,GO:0004383,GO:0004672,GO:0005524,GO:0005525,GO:0005886,GO:0005887,GO:0006182,GO:0007168,GO:0008074,GO:0008217,GO:0016941,GO:0017046,GO:0022414,GO:0035556,GO:0042562,GO:0042802,GO:0051447,GO:0060348,GO:0097011,GO:1900194,GO:1903779 ossification|guanylate cyclase activity|protein kinase activity|ATP binding|GTP binding|plasma membrane|integral component of plasma membrane|cGMP biosynthetic process|receptor guanylyl cyclase signaling pathway|guanylate cyclase complex, soluble|regulation of blood pressure|natriuretic peptide receptor activity|peptide hormone binding|reproductive process|intracellular signal transduction|hormone binding|identical protein binding|negative regulation of meiotic cell cycle|bone development|cellular response to granulocyte macrophage colony-stimulating factor stimulus|negative regulation of oocyte maturation|regulation of cardiac conduction hsa00230,hsa04022,hsa04270,hsa04921 Purine metabolism|cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Oxytocin signaling pathway NPR3 13.7809074284337 13.0202054438931 14.5416094129743 1.11684945952944 0.159434737632493 0.860191733254353 1 0.0782948 0.0398709 0.0804631 0.0373706 GeneID:4883,Genbank:XM_011514047.2,HGNC:HGNC:7945,MIM:108962 natriuretic peptide receptor 3 GO:0001501,GO:0002158,GO:0005622,GO:0005887,GO:0007193,GO:0007194,GO:0007200,GO:0008217,GO:0008528,GO:0016941,GO:0017046,GO:0030157,GO:0031404,GO:0033688,GO:0035810,GO:0042277,GO:0042562,GO:0042803,GO:0043234,GO:0048015,GO:0048662,GO:0051000,GO:0070062 skeletal system development|osteoclast proliferation|intracellular|integral component of plasma membrane|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|phospholipase C-activating G-protein coupled receptor signaling pathway|regulation of blood pressure|G-protein coupled peptide receptor activity|natriuretic peptide receptor activity|peptide hormone binding|pancreatic juice secretion|chloride ion binding|regulation of osteoblast proliferation|positive regulation of urine volume|peptide binding|hormone binding|protein homodimerization activity|protein complex|phosphatidylinositol-mediated signaling|negative regulation of smooth muscle cell proliferation|positive regulation of nitric-oxide synthase activity|extracellular exosome NPRL2 602.768322833383 611.943915211288 593.592730455478 0.970011655807585 -0.0439260118404118 0.843775405070321 1 7.07266 7.67213 5.83488 8.43046 GeneID:10641,Genbank:XM_005264808.5,HGNC:HGNC:24969,MIM:607072 NPR2 like, GATOR1 complex subunit GO:0004672,GO:0005096,GO:0005765,GO:0006995,GO:0010508,GO:0032007,GO:0033673,GO:0034198,GO:1990130,GO:2000785 protein kinase activity|GTPase activator activity|lysosomal membrane|cellular response to nitrogen starvation|positive regulation of autophagy|negative regulation of TOR signaling|negative regulation of kinase activity|cellular response to amino acid starvation|GATOR1 complex|regulation of autophagosome assembly hsa04150 mTOR signaling pathway NPRL3 650.636754124021 624.705388972395 676.568119275646 1.08301950202248 0.115059221910049 0.506640428985076 1 7.61035 8.75719 9.94576 8.89714 GeneID:8131,Genbank:NM_001077350.2,HGNC:HGNC:14124,MIM:600928 NPR3 like, GATOR1 complex subunit GO:0003281,GO:0005096,GO:0005765,GO:0032007,GO:0034198,GO:0035909,GO:0038202,GO:0048738,GO:0060021,GO:1990130,GO:2000785 ventricular septum development|GTPase activator activity|lysosomal membrane|negative regulation of TOR signaling|cellular response to amino acid starvation|aorta morphogenesis|TORC1 signaling|cardiac muscle tissue development|palate development|GATOR1 complex|regulation of autophagosome assembly hsa04150 mTOR signaling pathway NPTN 3516.15364857255 3515.19847787609 3517.108819269 1.0005434519288 0.000783822437017554 1 1 36.617 37.2987 40.3264 35.2449 GeneID:27020,Genbank:NM_001161364.1,HGNC:HGNC:17867,MIM:612820 neuroplastin GO:0001934,GO:0005105,GO:0007156,GO:0007204,GO:0008542,GO:0009986,GO:0010976,GO:0014069,GO:0016021,GO:0030425,GO:0042734,GO:0044325,GO:0045743,GO:0048170,GO:0050839,GO:0060077,GO:0060291,GO:0070374,GO:1900273,GO:1902683,GO:1903829,GO:1904861 positive regulation of protein phosphorylation|type 1 fibroblast growth factor receptor binding|homophilic cell adhesion via plasma membrane adhesion molecules|positive regulation of cytosolic calcium ion concentration|visual learning|cell surface|positive regulation of neuron projection development|postsynaptic density|integral component of membrane|dendrite|presynaptic membrane|ion channel binding|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|cell adhesion molecule binding|inhibitory synapse|long-term synaptic potentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of long-term synaptic potentiation|regulation of receptor localization to synapse|positive regulation of cellular protein localization|excitatory synapse assembly NPTX1 9.77463898255062 10.819788462639 8.72948950246227 0.806807779339258 -0.309703100227439 0.825002134732408 1 0.100421 0.080678 0.127957 0.00796239 GeneID:4884,Genbank:NM_002522.3,HGNC:HGNC:7952,MIM:602367 neuronal pentraxin 1 GO:0006810,GO:0007268,GO:0007417,GO:0030133,GO:0046872,GO:0060385 transport|chemical synaptic transmission|central nervous system development|transport vesicle|metal ion binding|axonogenesis involved in innervation NPTX2 1.459773021105 0.980142803914724 1.93940323829528 1.97869456425047 0.984548931915837 0.869473334580252 1 0 0.0374524 0.0399425 0.0186176 GeneID:4885,Genbank:NM_002523.2,HGNC:HGNC:7953,MIM:600750 neuronal pentraxin 2 GO:0005576,GO:0007268,GO:0008306,GO:0030246,GO:0046872 extracellular region|chemical synaptic transmission|associative learning|carbohydrate binding|metal ion binding NPTXR 268.154828707295 244.569970537774 291.739686876816 1.19286798062462 0.254434383152623 0.221417982825916 1 1.69796 1.67871 2.05577 2.05465 GeneID:23467,Genbank:NM_014293.3,HGNC:HGNC:7954,MIM:609474 neuronal pentraxin receptor GO:0016021,GO:0046872 integral component of membrane|metal ion binding NPW 1.26483015846966 1.07619535328461 1.45346496365472 1.35055866875717 0.43355631240266 1 1 0.0985526 0 0.087371 0 GeneID:283869,Genbank:NM_001099456.2,HGNC:HGNC:30509,MIM:607997 neuropeptide W GO:0001664,GO:0005576,GO:0007186,GO:0007218,GO:0007631 G-protein coupled receptor binding|extracellular region|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|feeding behavior NPY 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:4852,Genbank:NM_000905.3,HGNC:HGNC:7955,MIM:162640 neuropeptide Y hsa04024,hsa04920,hsa04923,hsa05034 cAMP signaling pathway|Adipocytokine signaling pathway|Regulation of lipolysis in adipocytes|Alcoholism NPY1R 769.109061307126 647.43772755861 890.780395055642 1.3758549388443 0.460328369718735 0.0168455334713764 0.538760869736292 8.32922 6.2434 10.7605 9.3681 GeneID:4886,Genbank:NM_000909.5,HGNC:HGNC:7956,MIM:162641 neuropeptide Y receptor Y1 hsa04024,hsa04080,hsa04923 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Regulation of lipolysis in adipocytes NPY2R 1.21430233409962 0.490071401957362 1.93853326624189 3.95561393400904 1.98390162663545 0.683537482026705 1 0 0.0106732 0.0217118 0.0201782 GeneID:4887,Genbank:XM_005263033.4,HGNC:HGNC:7957,MIM:162642 neuropeptide Y receptor Y2 GO:0001601,GO:0001662,GO:0002793,GO:0003151,GO:0003214,GO:0004872,GO:0004983,GO:0005246,GO:0005622,GO:0005886,GO:0005887,GO:0007186,GO:0007193,GO:0007204,GO:0007263,GO:0007268,GO:0007568,GO:0007626,GO:0007631,GO:0010811,GO:0031645,GO:0033603,GO:0043951,GO:0045987,GO:0046010,GO:0046903,GO:0051048,GO:0051930,GO:0051967,GO:0090394,GO:0097730,GO:2000252 peptide YY receptor activity|behavioral fear response|positive regulation of peptide secretion|outflow tract morphogenesis|cardiac left ventricle morphogenesis|receptor activity|neuropeptide Y receptor activity|calcium channel regulator activity|intracellular|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|nitric oxide mediated signal transduction|chemical synaptic transmission|aging|locomotory behavior|feeding behavior|positive regulation of cell-substrate adhesion|negative regulation of neurological system process|positive regulation of dopamine secretion|negative regulation of cAMP-mediated signaling|positive regulation of smooth muscle contraction|positive regulation of circadian sleep/wake cycle, non-REM sleep|secretion|negative regulation of secretion|regulation of sensory perception of pain|negative regulation of synaptic transmission, glutamatergic|negative regulation of excitatory postsynaptic potential|non-motile cilium|negative regulation of feeding behavior hsa04080 Neuroactive ligand-receptor interaction NPY4R 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00532044 0 0 GeneID:5540,Genbank:XM_011539936.3,HGNC:HGNC:9329,MIM:601790 neuropeptide Y receptor Y4 GO:0001602,GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0007218,GO:0007268,GO:0007586,GO:0007631,GO:0008015 pancreatic polypeptide receptor activity|G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|digestion|feeding behavior|blood circulation hsa04080 Neuroactive ligand-receptor interaction NQO1 17654.2052859769 16522.2885206018 18786.122051352 1.13701694701236 0.185253757474213 0.216671449020577 1 233.854 240.891 254.955 287.563 GeneID:1728,Genbank:NM_001286137.1,HGNC:HGNC:2874,MIM:125860 NAD(P)H quinone dehydrogenase 1 hsa00130,hsa05200,hsa05225,hsa05418 Ubiquinone and other terpenoid-quinone biosynthesis|Pathways in cancer|Hepatocellular carcinoma|Fluid shear stress and atherosclerosis NQO2 458.967586497381 458.035120033917 459.900052960846 1.00407159373891 0.00586214204725041 0.973599887586911 1 6.76162 6.55257 6.8347 7.22321 GeneID:4835,Genbank:NM_001290221.1,HGNC:HGNC:7856,MIM:160998 N-ribosyldihydronicotinamide:quinone reductase 2 NR0B1 14.7449638238932 11.559799893129 17.9301277546573 1.5510759632885 0.633269343482939 0.434653610249645 1 0.270767 0.615178 0.705442 0.735415 GeneID:190,Genbank:NM_000475.4,HGNC:HGNC:7960,MIM:300473 nuclear receptor subfamily 0 group B member 1 GO:0000122,GO:0003677,GO:0003707,GO:0003714,GO:0003723,GO:0004879,GO:0005634,GO:0005654,GO:0005737,GO:0005815,GO:0006367,GO:0006694,GO:0007283,GO:0008104,GO:0008134,GO:0008406,GO:0008584,GO:0016020,GO:0016607,GO:0019904,GO:0021854,GO:0021983,GO:0030238,GO:0030325,GO:0032448,GO:0033144,GO:0033327,GO:0035258,GO:0035902,GO:0042788,GO:0042803,GO:0043231,GO:0043433,GO:0043565,GO:0045596,GO:0045892,GO:0050682,GO:0060008 negative regulation of transcription from RNA polymerase II promoter|DNA binding|steroid hormone receptor activity|transcription corepressor activity|RNA binding|nuclear receptor activity|nucleus|nucleoplasm|cytoplasm|microtubule organizing center|transcription initiation from RNA polymerase II promoter|steroid biosynthetic process|spermatogenesis|protein localization|transcription factor binding|gonad development|male gonad development|membrane|nuclear speck|protein domain specific binding|hypothalamus development|pituitary gland development|male sex determination|adrenal gland development|DNA hairpin binding|negative regulation of intracellular steroid hormone receptor signaling pathway|Leydig cell differentiation|steroid hormone receptor binding|response to immobilization stress|polysomal ribosome|protein homodimerization activity|intracellular membrane-bounded organelle|negative regulation of DNA binding transcription factor activity|sequence-specific DNA binding|negative regulation of cell differentiation|negative regulation of transcription, DNA-templated|AF-2 domain binding|Sertoli cell differentiation hsa04927 Cortisol synthesis and secretion NR1D1 379.012660493152 356.285615872982 401.739705113323 1.12757767143916 0.173226814713998 0.377098789928242 1 5.0215 5.68643 5.66349 6.23525 GeneID:9572,Genbank:NM_021724.4,HGNC:HGNC:7962,MIM:602408 nuclear receptor subfamily 1 group D member 1 GO:0000122,GO:0000790,GO:0000977,GO:0000978,GO:0001046,GO:0001078,GO:0001222,GO:0003707,GO:0003714,GO:0004879,GO:0005634,GO:0005654,GO:0005737,GO:0005978,GO:0006367,GO:0007623,GO:0008270,GO:0010498,GO:0010871,GO:0016604,GO:0019216,GO:0020037,GO:0030154,GO:0030425,GO:0032922,GO:0034144,GO:0035947,GO:0042752,GO:0043197,GO:0044212,GO:0044321,GO:0045598,GO:0045892,GO:0045893,GO:0060086,GO:0061178,GO:0061469,GO:0070859,GO:0071222,GO:2000188 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|core promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcription corepressor binding|steroid hormone receptor activity|transcription corepressor activity|nuclear receptor activity|nucleus|nucleoplasm|cytoplasm|glycogen biosynthetic process|transcription initiation from RNA polymerase II promoter|circadian rhythm|zinc ion binding|proteasomal protein catabolic process|negative regulation of receptor biosynthetic process|nuclear body|regulation of lipid metabolic process|heme binding|cell differentiation|dendrite|circadian regulation of gene expression|negative regulation of toll-like receptor 4 signaling pathway|regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter|regulation of circadian rhythm|dendritic spine|transcription regulatory region DNA binding|response to leptin|regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|circadian temperature homeostasis|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of type B pancreatic cell proliferation|positive regulation of bile acid biosynthetic process|cellular response to lipopolysaccharide|regulation of cholesterol homeostasis hsa04710 Circadian rhythm NR1D2 594.050082208107 630.690072998652 557.410091417561 0.883809838273375 -0.17819210410789 0.498250072353022 1 5.6528 5.12125 5.82985 3.821 GeneID:9975,Genbank:NM_005126.4,HGNC:HGNC:7963,MIM:602304 nuclear receptor subfamily 1 group D member 2 GO:0000980,GO:0001046,GO:0001206,GO:0003707,GO:0004879,GO:0005634,GO:0005654,GO:0006355,GO:0006367,GO:0008270,GO:0019216,GO:0042752,GO:0045892,GO:0045893,GO:0048511,GO:0050727,GO:0055088,GO:2000505,GO:2001014 RNA polymerase II distal enhancer sequence-specific DNA binding|core promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding|steroid hormone receptor activity|nuclear receptor activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|zinc ion binding|regulation of lipid metabolic process|regulation of circadian rhythm|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|rhythmic process|regulation of inflammatory response|lipid homeostasis|regulation of energy homeostasis|regulation of skeletal muscle cell differentiation NR1H2 2368.2535302221 2234.93688692162 2501.57017352259 1.11930237858673 0.162599831807863 0.254935861047603 1 48.1847 51.8656 56.6857 57.7834 GeneID:7376,Genbank:NM_007121.5,HGNC:HGNC:7965,MIM:600380 nuclear receptor subfamily 1 group H member 2 GO:0000122,GO:0000978,GO:0001077,GO:0001133,GO:0003677,GO:0003707,GO:0004879,GO:0005634,GO:0005654,GO:0005737,GO:0006367,GO:0008270,GO:0010745,GO:0010867,GO:0010875,GO:0010884,GO:0010887,GO:0032270,GO:0032369,GO:0032376,GO:0034191,GO:0042632,GO:0044255,GO:0045723,GO:0045861,GO:0045892,GO:0045893,GO:0045944,GO:0046965,GO:0048384,GO:0048550,GO:0051006,GO:0051117,GO:0060336,GO:0090108,GO:0090187,GO:0090340,GO:2000188 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding|DNA binding|steroid hormone receptor activity|nuclear receptor activity|nucleus|nucleoplasm|cytoplasm|transcription initiation from RNA polymerase II promoter|zinc ion binding|negative regulation of macrophage derived foam cell differentiation|positive regulation of triglyceride biosynthetic process|positive regulation of cholesterol efflux|positive regulation of lipid storage|negative regulation of cholesterol storage|positive regulation of cellular protein metabolic process|negative regulation of lipid transport|positive regulation of cholesterol transport|apolipoprotein A-I receptor binding|cholesterol homeostasis|cellular lipid metabolic process|positive regulation of fatty acid biosynthetic process|negative regulation of proteolysis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|retinoid X receptor binding|retinoic acid receptor signaling pathway|negative regulation of pinocytosis|positive regulation of lipoprotein lipase activity|ATPase binding|negative regulation of interferon-gamma-mediated signaling pathway|positive regulation of high-density lipoprotein particle assembly|positive regulation of pancreatic juice secretion|positive regulation of secretion of lysosomal enzymes|regulation of cholesterol homeostasis hsa04931 Insulin resistance NR1H3 121.412621088483 114.886396465269 127.938845711697 1.11361179084744 0.155246391539115 0.616862180885251 1 0.978144 1.02559 1.02204 0.996882 GeneID:10062,Genbank:NM_001251935.1,HGNC:HGNC:7966,MIM:602423 nuclear receptor subfamily 1 group H member 3 GO:0000122,GO:0000790,GO:0003677,GO:0003707,GO:0003713,GO:0004879,GO:0005634,GO:0005654,GO:0006367,GO:0008270,GO:0010745,GO:0010867,GO:0010870,GO:0010875,GO:0010887,GO:0015485,GO:0032270,GO:0032369,GO:0032376,GO:0032570,GO:0032810,GO:0034145,GO:0042632,GO:0042752,GO:0043031,GO:0043235,GO:0043277,GO:0044212,GO:0045723,GO:0045893,GO:0045944,GO:0048550,GO:0050728,GO:0051006,GO:0055088,GO:0055092,GO:0060336,GO:0070328,GO:0071222,GO:0090188,GO:0090341,GO:0090575,GO:2000188,GO:2000189 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|DNA binding|steroid hormone receptor activity|transcription coactivator activity|nuclear receptor activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|zinc ion binding|negative regulation of macrophage derived foam cell differentiation|positive regulation of triglyceride biosynthetic process|positive regulation of receptor biosynthetic process|positive regulation of cholesterol efflux|negative regulation of cholesterol storage|cholesterol binding|positive regulation of cellular protein metabolic process|negative regulation of lipid transport|positive regulation of cholesterol transport|response to progesterone|sterol response element binding|positive regulation of toll-like receptor 4 signaling pathway|cholesterol homeostasis|regulation of circadian rhythm|negative regulation of macrophage activation|receptor complex|apoptotic cell clearance|transcription regulatory region DNA binding|positive regulation of fatty acid biosynthetic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of pinocytosis|negative regulation of inflammatory response|positive regulation of lipoprotein lipase activity|lipid homeostasis|sterol homeostasis|negative regulation of interferon-gamma-mediated signaling pathway|triglyceride homeostasis|cellular response to lipopolysaccharide|negative regulation of pancreatic juice secretion|negative regulation of secretion of lysosomal enzymes|RNA polymerase II transcription factor complex|regulation of cholesterol homeostasis|positive regulation of cholesterol homeostasis hsa03320,hsa04931,hsa04932,hsa05160 PPAR signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hepatitis C NR1H4 30.2960357709895 38.7822673386777 21.8098042033013 0.562365372113 -0.830420332302832 0.105404798858228 1 0.245553 0.278349 0.178557 0.140237 GeneID:9971,Genbank:NM_001206977.1,HGNC:HGNC:7967,MIM:603826 nuclear receptor subfamily 1 group H member 4 hsa04976 Bile secretion NR1I3 9.56851735054989 13.8082431490681 5.32879155203169 0.385913797613807 -1.37364946926898 0.1516947208863 1 0.0747428 0.0889893 0 0.129134 GeneID:9970,Genbank:XM_005245694.5,HGNC:HGNC:7969,MIM:603881 nuclear receptor subfamily 1 group I member 3 GO:0003707,GO:0004887,GO:0005634,GO:0005737,GO:0005856,GO:0006351,GO:0008270,GO:0043565 steroid hormone receptor activity|thyroid hormone receptor activity|nucleus|cytoplasm|cytoskeleton|transcription, DNA-templated|zinc ion binding|sequence-specific DNA binding NR2C1 166.243413682318 171.588566266559 160.898261098077 0.937698033143567 -0.0928046883773135 0.7478917416215 1 1.13452 1.07897 1.17497 0.950887 GeneID:7181,Genbank:NM_003297.3,HGNC:HGNC:7971,MIM:601529 nuclear receptor subfamily 2 group C member 1 GO:0000978,GO:0001078,GO:0003677,GO:0003707,GO:0004872,GO:0005654,GO:0006367,GO:0008270,GO:0016605,GO:0042803,GO:0042826,GO:0048386 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|steroid hormone receptor activity|receptor activity|nucleoplasm|transcription initiation from RNA polymerase II promoter|zinc ion binding|PML body|protein homodimerization activity|histone deacetylase binding|positive regulation of retinoic acid receptor signaling pathway NR2C2 1692.96390556027 1758.36122950417 1627.56658161637 0.925615598380384 -0.111514918086288 0.5423550396646 1 6.88168 6.55595 7.25238 5.36544 GeneID:7182,Genbank:NM_003298.4,HGNC:HGNC:7972,MIM:601426 nuclear receptor subfamily 2 group C member 2 GO:0000977,GO:0000978,GO:0001077,GO:0001228,GO:0003700,GO:0003707,GO:0003713,GO:0004872,GO:0005654,GO:0006355,GO:0006367,GO:0007283,GO:0007399,GO:0008270,GO:0030154,GO:0043565,GO:0045944,GO:0046982 RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|receptor activity|nucleoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|spermatogenesis|nervous system development|zinc ion binding|cell differentiation|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity NR2C2AP 674.236716663816 722.332408163824 626.141025163809 0.866832247988797 -0.206175269157542 0.210564585737995 1 20.9804 20.108 19.2154 17.5759 GeneID:126382,Genbank:NM_001300945.1,HGNC:HGNC:30763,MIM:608719 nuclear receptor 2C2 associated protein GO:0005654,GO:0006367,GO:0070062 nucleoplasm|transcription initiation from RNA polymerase II promoter|extracellular exosome NR2E1 282.543076525471 286.878790239523 278.207362811419 0.969773201354957 -0.0442807079364726 0.828032872349376 1 3.01928 3.20718 3.45674 2.70213 GeneID:7101,Genbank:NM_003269.4,HGNC:HGNC:7973,MIM:603849 nuclear receptor subfamily 2 group E member 1 GO:0001077,GO:0001078,GO:0001662,GO:0002118,GO:0003707,GO:0005654,GO:0006367,GO:0007399,GO:0007601,GO:0008270,GO:0021542,GO:0021764,GO:0021772,GO:0021819,GO:0021872,GO:0021895,GO:0021960,GO:0030198,GO:0035019,GO:0035176,GO:0042826,GO:0043066,GO:0043565,GO:0045165,GO:0045665,GO:0045766,GO:0045787,GO:0048712,GO:0048814,GO:0060041,GO:0060164,GO:0060291,GO:0090049,GO:2000178,GO:2000179,GO:2000648 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|behavioral fear response|aggressive behavior|steroid hormone receptor activity|nucleoplasm|transcription initiation from RNA polymerase II promoter|nervous system development|visual perception|zinc ion binding|dentate gyrus development|amygdala development|olfactory bulb development|layer formation in cerebral cortex|forebrain generation of neurons|cerebral cortex neuron differentiation|anterior commissure morphogenesis|extracellular matrix organization|somatic stem cell population maintenance|social behavior|histone deacetylase binding|negative regulation of apoptotic process|sequence-specific DNA binding|cell fate commitment|negative regulation of neuron differentiation|positive regulation of angiogenesis|positive regulation of cell cycle|negative regulation of astrocyte differentiation|regulation of dendrite morphogenesis|retina development in camera-type eye|regulation of timing of neuron differentiation|long-term synaptic potentiation|regulation of cell migration involved in sprouting angiogenesis|negative regulation of neural precursor cell proliferation|positive regulation of neural precursor cell proliferation|positive regulation of stem cell proliferation NR2E3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.013495 0 0 GeneID:10002,Genbank:NM_014249.3,HGNC:HGNC:7974,MIM:604485 nuclear receptor subfamily 2 group E member 3 NR2F1 2122.82845609205 1840.34824945596 2405.30866272813 1.3069856009259 0.386243247034477 0.00602419473583855 0.309722908597509 22.4221 22.9434 32.2876 28.1825 GeneID:7025,Genbank:NM_005654.5,HGNC:HGNC:7975,MIM:132890 nuclear receptor subfamily 2 group F member 1 GO:0000122,GO:0000978,GO:0001078,GO:0003700,GO:0003707,GO:0003713,GO:0004879,GO:0005634,GO:0005654,GO:0005829,GO:0006367,GO:0007165,GO:0008270,GO:0010977,GO:0043565,GO:0044323,GO:0045944 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|nuclear receptor activity|nucleus|nucleoplasm|cytosol|transcription initiation from RNA polymerase II promoter|signal transduction|zinc ion binding|negative regulation of neuron projection development|sequence-specific DNA binding|retinoic acid-responsive element binding|positive regulation of transcription from RNA polymerase II promoter NR2F2 3238.12774167921 3061.31425177615 3414.94123158227 1.11551475958437 0.157709602276183 0.247891252714168 1 21.6239 22.0005 26.919 22.4107 GeneID:7026,Genbank:NM_001145155.1,HGNC:HGNC:7976,MIM:107773 nuclear receptor subfamily 2 group F member 2 GO:0000122,GO:0001764,GO:0001893,GO:0001937,GO:0001972,GO:0003084,GO:0003700,GO:0003707,GO:0003714,GO:0004879,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006357,GO:0006629,GO:0007165,GO:0007519,GO:0008270,GO:0009566,GO:0009952,GO:0009956,GO:0010596,GO:0030900,GO:0032355,GO:0042803,GO:0043565,GO:0045736,GO:0045892,GO:0045893,GO:0048514,GO:0060173,GO:0060674,GO:0060707,GO:0060849 negative regulation of transcription from RNA polymerase II promoter|neuron migration|maternal placenta development|negative regulation of endothelial cell proliferation|retinoic acid binding|positive regulation of systemic arterial blood pressure|DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|nuclear receptor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|lipid metabolic process|signal transduction|skeletal muscle tissue development|zinc ion binding|fertilization|anterior/posterior pattern specification|radial pattern formation|negative regulation of endothelial cell migration|forebrain development|response to estradiol|protein homodimerization activity|sequence-specific DNA binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|blood vessel morphogenesis|limb development|placenta blood vessel development|trophoblast giant cell differentiation|regulation of transcription involved in lymphatic endothelial cell fate commitment NR2F6 1276.62067641785 1317.96192228817 1235.27943054752 0.937264885773705 -0.0934712611050035 0.505999686147712 1 46.8846 49.6704 45.4462 46.9928 GeneID:2063,Genbank:NM_005234.3,HGNC:HGNC:7977,MIM:132880 nuclear receptor subfamily 2 group F member 6 GO:0000122,GO:0000980,GO:0001227,GO:0003677,GO:0003700,GO:0003707,GO:0004879,GO:0004887,GO:0005634,GO:0005654,GO:0006367,GO:0007165,GO:0008270,GO:0043153,GO:0043565,GO:0048666,GO:0050965 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|thyroid hormone receptor activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|signal transduction|zinc ion binding|entrainment of circadian clock by photoperiod|sequence-specific DNA binding|neuron development|detection of temperature stimulus involved in sensory perception of pain NR3C1 1287.47171813844 1325.89504926544 1249.04838701144 0.942041670419859 -0.0861372172378018 0.728685557958346 1 3.0108 2.6824 3.10198 2.23991 GeneID:2908,Genbank:NM_001018075.1,HGNC:HGNC:7978,MIM:138040 nuclear receptor subfamily 3 group C member 1 hsa04080 Neuroactive ligand-receptor interaction NR3C2 104.275805537917 85.9241574750995 122.627453600734 1.4271592204587 0.513146297499127 0.0776789404177018 0.94157495521624 0.472772 0.403457 0.698907 0.521101 GeneID:4306,Genbank:NM_001354819.1,HGNC:HGNC:7979,MIM:600983 nuclear receptor subfamily 3 group C member 2 hsa04960 Aldosterone-regulated sodium reabsorption NR4A1 129.86327380696 113.368155984712 146.358391629209 1.29100090195474 0.368490008580952 0.18602652529134 1 0.416042 0.643544 0.703394 0.683612 GeneID:3164,Genbank:NM_001202233.1,HGNC:HGNC:7980,MIM:139139 nuclear receptor subfamily 4 group A member 1 hsa04010,hsa04151,hsa04925,hsa04927,hsa04934 MAPK signaling pathway|PI3K-Akt signaling pathway|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome NR4A2 37.1668401869905 37.5041582315454 36.8295221424356 0.982011698944298 -0.0261878830679783 0.992006998222143 1 0.307727 0.302565 0.313169 0.407172 GeneID:4929,Genbank:NM_006186.3,HGNC:HGNC:7981,MIM:601828 nuclear receptor subfamily 4 group A member 2 GO:0000122,GO:0000978,GO:0001077,GO:0001666,GO:0001764,GO:0001975,GO:0003677,GO:0003707,GO:0004879,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006367,GO:0007165,GO:0008013,GO:0008270,GO:0008344,GO:0009791,GO:0016607,GO:0021952,GO:0021986,GO:0031668,GO:0034599,GO:0035259,GO:0042053,GO:0042416,GO:0042551,GO:0042803,GO:0043085,GO:0043524,GO:0043576,GO:0045444,GO:0045944,GO:0046965,GO:0046982,GO:0051866,GO:0060070,GO:0071376,GO:0071542,GO:1904948,GO:2001234 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|response to hypoxia|neuron migration|response to amphetamine|DNA binding|steroid hormone receptor activity|nuclear receptor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|signal transduction|beta-catenin binding|zinc ion binding|adult locomotory behavior|post-embryonic development|nuclear speck|central nervous system projection neuron axonogenesis|habenula development|cellular response to extracellular stimulus|cellular response to oxidative stress|glucocorticoid receptor binding|regulation of dopamine metabolic process|dopamine biosynthetic process|neuron maturation|protein homodimerization activity|positive regulation of catalytic activity|negative regulation of neuron apoptotic process|regulation of respiratory gaseous exchange|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|retinoid X receptor binding|protein heterodimerization activity|general adaptation syndrome|canonical Wnt signaling pathway|cellular response to corticotropin-releasing hormone stimulus|dopaminergic neuron differentiation|midbrain dopaminergic neuron differentiation|negative regulation of apoptotic signaling pathway hsa04925,hsa04928 Aldosterone synthesis and secretion|Parathyroid hormone synthesis, secretion and action NR4A3 5.84582553323813 6.36111957033777 5.33053149613849 0.837986369725706 -0.255001316940127 0.942327623164993 1 0.0496387 0.00660129 0.026977 0.0377219 GeneID:8013,Genbank:NM_173200.2,HGNC:HGNC:7982,MIM:600542 nuclear receptor subfamily 4 group A member 3 hsa05202 Transcriptional misregulation in cancer NR5A1 2.24497296238439 3.03648096111406 1.45346496365472 0.478667570213071 -1.06290402828578 0.698606856036559 1 0.0351853 0.0455665 0.0162464 0.0303432 GeneID:2516,Genbank:NM_004959.4,HGNC:HGNC:7983,MIM:184757 nuclear receptor subfamily 5 group A member 1 GO:0000977,GO:0000980,GO:0001553,GO:0003677,GO:0003682,GO:0003705,GO:0003707,GO:0003713,GO:0004879,GO:0005543,GO:0005634,GO:0005654,GO:0006367,GO:0007267,GO:0007530,GO:0007538,GO:0008270,GO:0008584,GO:0008585,GO:0009755,GO:0009888,GO:0010259,GO:0010628,GO:0019899,GO:0030154,GO:0030325,GO:0042445,GO:0043565,GO:0045944,GO:0050810,GO:0051457,GO:0090575,GO:0097210,GO:0097720,GO:2000020,GO:2000195 RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|luteinization|DNA binding|chromatin binding|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|steroid hormone receptor activity|transcription coactivator activity|nuclear receptor activity|phospholipid binding|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|cell-cell signaling|sex determination|primary sex determination|zinc ion binding|male gonad development|female gonad development|hormone-mediated signaling pathway|tissue development|multicellular organism aging|positive regulation of gene expression|enzyme binding|cell differentiation|adrenal gland development|hormone metabolic process|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|regulation of steroid biosynthetic process|maintenance of protein location in nucleus|RNA polymerase II transcription factor complex|response to gonadotropin-releasing hormone|calcineurin-mediated signaling|positive regulation of male gonad development|negative regulation of female gonad development hsa04927,hsa04934 Cortisol synthesis and secretion|Cushing syndrome NR5A2 2.61594742149901 4.74682654041085 0.48506830258717 0.102187914063779 -3.29070351848777 0.183296200031735 1 0.0222184 0.0103882 0.0052953 0 GeneID:2494,Genbank:NM_205860.2,HGNC:HGNC:7984,MIM:604453 nuclear receptor subfamily 5 group A member 2 GO:0000976,GO:0000978,GO:0000980,GO:0001077,GO:0003677,GO:0003682,GO:0003700,GO:0003705,GO:0003707,GO:0004879,GO:0005543,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006367,GO:0008206,GO:0008270,GO:0009755,GO:0009790,GO:0009888,GO:0030855,GO:0042127,GO:0042592,GO:0042632,GO:0043565,GO:0044212,GO:0045070,GO:0045893,GO:0045944,GO:0061113,GO:0090575,GO:0097720,GO:1990830 transcription regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|chromatin binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|steroid hormone receptor activity|nuclear receptor activity|phospholipid binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|bile acid metabolic process|zinc ion binding|hormone-mediated signaling pathway|embryo development|tissue development|epithelial cell differentiation|regulation of cell proliferation|homeostatic process|cholesterol homeostasis|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of viral genome replication|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|pancreas morphogenesis|RNA polymerase II transcription factor complex|calcineurin-mediated signaling|cellular response to leukemia inhibitory factor hsa04950 Maturity onset diabetes of the young NR6A1 64.6981267107739 62.0361372938825 67.3601161276652 1.08582060498966 0.11878576642904 0.761251690276909 1 0.253367 0.261818 0.269426 0.269356 GeneID:2649,Genbank:NM_001489.4,HGNC:HGNC:7985,MIM:602778 nuclear receptor subfamily 6 group A member 1 GO:0000122,GO:0000978,GO:0001077,GO:0003677,GO:0003707,GO:0004879,GO:0005634,GO:0005654,GO:0005667,GO:0006367,GO:0007276,GO:0007283,GO:0008270,GO:0008283,GO:0030518,GO:0042803,GO:0043565 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|steroid hormone receptor activity|nuclear receptor activity|nucleus|nucleoplasm|transcription factor complex|transcription initiation from RNA polymerase II promoter|gamete generation|spermatogenesis|zinc ion binding|cell proliferation|intracellular steroid hormone receptor signaling pathway|protein homodimerization activity|sequence-specific DNA binding NRAP 1.27026824386655 2.05633815719933 0.484198330533773 0.235466296649008 -2.08640751970762 0.631842364882622 1 0.0059619 0.0054588 0 0 GeneID:4892,Genbank:NM_006175.4,HGNC:HGNC:7988,MIM:602873 nebulin related anchoring protein GO:0003779,GO:0005916,GO:0005927,GO:0046872,GO:0051371 actin binding|fascia adherens|muscle tendon junction|metal ion binding|muscle alpha-actinin binding NRARP 70.2601846948801 84.3098644451726 56.2105049445875 0.666713264390807 -0.584861664786857 0.094164822341538 0.993092841119221 2.26444 1.9997 1.29058 1.59202 GeneID:441478,Genbank:NM_001004354.2,HGNC:HGNC:33843 NOTCH regulated ankyrin repeat protein GO:0000122,GO:0001569,GO:0001938,GO:0002043,GO:0007219,GO:0032525,GO:0045581,GO:0045746,GO:0090263,GO:1902367 negative regulation of transcription from RNA polymerase II promoter|branching involved in blood vessel morphogenesis|positive regulation of endothelial cell proliferation|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|Notch signaling pathway|somite rostral/caudal axis specification|negative regulation of T cell differentiation|negative regulation of Notch signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of Notch signaling pathway involved in somitogenesis NRAS 2897.35509385919 3140.28608072531 2654.42410699307 0.845280983565668 -0.242497101169127 0.0825558527094917 0.963011316092657 33.4812 30.2998 28.8686 25.3078 GeneID:4893,Genbank:NM_002524.4,HGNC:HGNC:7989,MIM:164790 NRAS proto-oncogene, GTPase hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04062,hsa04068,hsa04071,hsa04072,hsa04137,hsa04140,hsa04150,hsa04151,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04371,hsa04540,hsa04550,hsa04625,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04720,hsa04722,hsa04725,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04933,hsa05034,hsa05160,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05216,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Cholinergic synapse|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Alcoholism|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer NRBF2 705.08074704879 735.554527361565 674.606966736016 0.917140662781089 -0.124785076515384 0.446761713606424 1 11.8792 12.0968 11.2744 10.7801 GeneID:29982,Genbank:NM_030759.4,HGNC:HGNC:19692,MIM:616477 nuclear receptor binding factor 2 GO:0005654,GO:0005737,GO:0005776,GO:0006355,GO:0006367,GO:0006914,GO:0031410,GO:0034976,GO:0035032,GO:0043550 nucleoplasm|cytoplasm|autophagosome|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|autophagy|cytoplasmic vesicle|response to endoplasmic reticulum stress|phosphatidylinositol 3-kinase complex, class III|regulation of lipid kinase activity hsa04140 Autophagy - animal NRBP1 3046.21450474126 3151.2168153967 2941.21219408582 0.933357609579636 -0.0994981491601878 0.461405480731364 1 33.9152 34.5455 33.4393 31.7915 GeneID:29959,Genbank:NM_001321357.1,HGNC:HGNC:7993,MIM:606010 nuclear receptor binding protein 1 GO:0004674,GO:0005524,GO:0005654,GO:0005829,GO:0005938,GO:0006367,GO:0006468,GO:0006888,GO:0012505,GO:0016020,GO:0030027,GO:0035556,GO:0042803 protein serine/threonine kinase activity|ATP binding|nucleoplasm|cytosol|cell cortex|transcription initiation from RNA polymerase II promoter|protein phosphorylation|ER to Golgi vesicle-mediated transport|endomembrane system|membrane|lamellipodium|intracellular signal transduction|protein homodimerization activity NRBP2 692.002357910183 622.186371376853 761.818344443513 1.22442145873055 0.292100234306896 0.0692606990549455 0.918407228165493 5.4493 4.76409 6.28444 6.31476 GeneID:340371,Genbank:XM_017013382.1,HGNC:HGNC:19339,MIM:615563 nuclear receptor binding protein 2 GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006888,GO:0012505,GO:0016242,GO:0030182,GO:0035556,GO:0043524 protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|ER to Golgi vesicle-mediated transport|endomembrane system|negative regulation of macroautophagy|neuron differentiation|intracellular signal transduction|negative regulation of neuron apoptotic process NRCAM 2121.87035754549 1973.37201144448 2270.3687036465 1.1505021306067 0.202263655281141 0.474514253511443 1 5.39638 4.81823 7.20577 4.72738 GeneID:4897,Genbank:NM_005010.4,HGNC:HGNC:7994,MIM:601581 neuronal cell adhesion molecule hsa04514 Cell adhesion molecules (CAMs) NRDC 3034.32300798303 3024.97827344384 3043.66774252223 1.00617838126061 0.00888609733675087 0.924713782272393 1 19.8553 18.3662 21.4278 17.6059 GeneID:4898,Genbank:NM_001101662.1,HGNC:HGNC:7995,MIM:602651 nardilysin convertase GO:0004222,GO:0005739,GO:0005829,GO:0006508,GO:0007528,GO:0008283,GO:0009986,GO:0016477,GO:0046872,GO:0048408,GO:0051044,GO:0052548 metalloendopeptidase activity|mitochondrion|cytosol|proteolysis|neuromuscular junction development|cell proliferation|cell surface|cell migration|metal ion binding|epidermal growth factor binding|positive regulation of membrane protein ectodomain proteolysis|regulation of endopeptidase activity NRDE2 367.322699252159 376.031533774476 358.613864729841 0.953680296783085 -0.0684223837372621 0.723363682522727 1 2.37699 2.36745 2.33139 2.37668 GeneID:55051,Genbank:XM_017021394.2,HGNC:HGNC:20186 NRDE-2, necessary for RNA interference, domain containing GO:0016246,GO:0031048,GO:0071013 RNA interference|chromatin silencing by small RNA|catalytic step 2 spliceosome NREP 732.274550974822 751.650448387004 712.89865356264 0.948444393391207 -0.0763649029379282 0.625961950181561 1 9.03937 9.75977 9.12786 8.36629 GeneID:9315,Genbank:NM_001142474.1,HGNC:HGNC:16834,MIM:607332 neuronal regeneration related protein GO:0005737 cytoplasm NRF1 633.150898120214 662.948541633576 603.353254606852 0.910105712156973 -0.135893965458491 0.415272780267561 1 6.59337 6.12704 6.03778 5.74733 GeneID:4899,Genbank:NM_001293163.1,HGNC:HGNC:7996,MIM:600879 nuclear respiratory factor 1 hsa04371,hsa05016 Apelin signaling pathway|Huntington disease NRG1 1493.02325615582 1474.74146829068 1511.30504402095 1.02479321055009 0.0353328226948429 0.882306771817951 1 3.42697 3.44368 4.25 2.86585 GeneID:3084,Genbank:NM_001159999.2,HGNC:HGNC:7997,MIM:142445 neuregulin 1 GO:0000165,GO:0000187,GO:0000902,GO:0001964,GO:0003161,GO:0003222,GO:0003712,GO:0005102,GO:0005176,GO:0005178,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0007169,GO:0007171,GO:0007399,GO:0007416,GO:0007420,GO:0007422,GO:0007507,GO:0007517,GO:0007613,GO:0007626,GO:0008083,GO:0008283,GO:0008284,GO:0008366,GO:0009790,GO:0009897,GO:0010001,GO:0010625,GO:0010628,GO:0010667,GO:0010976,GO:0014068,GO:0016324,GO:0016477,GO:0021781,GO:0021842,GO:0022008,GO:0030296,GO:0030307,GO:0030424,GO:0030425,GO:0030673,GO:0030971,GO:0031594,GO:0031643,GO:0032148,GO:0032570,GO:0035556,GO:0038127,GO:0038129,GO:0042060,GO:0042177,GO:0043125,GO:0043497,GO:0043624,GO:0044297,GO:0045202,GO:0045213,GO:0045499,GO:0045595,GO:0045773,GO:0045785,GO:0045860,GO:0045892,GO:0045944,GO:0046579,GO:0048513,GO:0048663,GO:0048680,GO:0048709,GO:0048738,GO:0050731,GO:0051048,GO:0051155,GO:0051897,GO:0055007,GO:0055012,GO:0060045,GO:0060379,GO:0060956,GO:0060999,GO:0070886,GO:1903955,GO:2000010,GO:2000727,GO:2000853,GO:2001223,GO:2001240 MAPK cascade|activation of MAPK activity|cell morphogenesis|startle response|cardiac conduction system development|ventricular trabecula myocardium morphogenesis|transcription cofactor activity|receptor binding|ErbB-2 class receptor binding|integrin binding|extracellular region|extracellular space|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|activation of transmembrane receptor protein tyrosine kinase activity|nervous system development|synapse assembly|brain development|peripheral nervous system development|heart development|muscle organ development|memory|locomotory behavior|growth factor activity|cell proliferation|positive regulation of cell proliferation|axon ensheathment|embryo development|external side of plasma membrane|glial cell differentiation|positive regulation of Schwann cell proliferation|positive regulation of gene expression|negative regulation of cardiac muscle cell apoptotic process|positive regulation of neuron projection development|positive regulation of phosphatidylinositol 3-kinase signaling|apical plasma membrane|cell migration|glial cell fate commitment|chemorepulsion involved in interneuron migration from the subpallium to the cortex|neurogenesis|protein tyrosine kinase activator activity|positive regulation of cell growth|axon|dendrite|axolemma|receptor tyrosine kinase binding|neuromuscular junction|positive regulation of myelination|activation of protein kinase B activity|response to progesterone|intracellular signal transduction|ERBB signaling pathway|ERBB3 signaling pathway|wound healing|negative regulation of protein catabolic process|ErbB-3 class receptor binding|regulation of protein heterodimerization activity|cellular protein complex disassembly|cell body|synapse|neurotransmitter receptor metabolic process|chemorepellent activity|regulation of cell differentiation|positive regulation of axon extension|positive regulation of cell adhesion|positive regulation of protein kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Ras protein signal transduction|animal organ development|neuron fate commitment|positive regulation of axon regeneration|oligodendrocyte differentiation|cardiac muscle tissue development|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of secretion|positive regulation of striated muscle cell differentiation|positive regulation of protein kinase B signaling|cardiac muscle cell differentiation|ventricular cardiac muscle cell differentiation|positive regulation of cardiac muscle cell proliferation|cardiac muscle cell myoblast differentiation|endocardial cell differentiation|positive regulation of dendritic spine development|positive regulation of calcineurin-NFAT signaling cascade|positive regulation of protein targeting to mitochondrion|positive regulation of protein localization to cell surface|positive regulation of cardiac muscle cell differentiation|negative regulation of corticosterone secretion|negative regulation of neuron migration|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa01521,hsa04012 EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway NRG2 305.711879718982 280.411809464707 331.011949973256 1.18044939193232 0.239336191864458 0.231908551318765 1 0.934807 0.921169 1.19924 1.11396 GeneID:9542,Genbank:NM_001184935.1,HGNC:HGNC:7998,MIM:603818 neuregulin 2 GO:0000165,GO:0004713,GO:0005088,GO:0005102,GO:0005576,GO:0005615,GO:0005622,GO:0005886,GO:0007165,GO:0008083,GO:0016021,GO:0035556,GO:0038128,GO:0046934,GO:0048513,GO:0051897,GO:1901185,GO:2000145 MAPK cascade|protein tyrosine kinase activity|Ras guanyl-nucleotide exchange factor activity|receptor binding|extracellular region|extracellular space|intracellular|plasma membrane|signal transduction|growth factor activity|integral component of membrane|intracellular signal transduction|ERBB2 signaling pathway|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|animal organ development|positive regulation of protein kinase B signaling|negative regulation of ERBB signaling pathway|regulation of cell motility hsa01521,hsa04012 EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway NRG3 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0 0 GeneID:10718,Genbank:XM_017015573.2,HGNC:HGNC:7999,MIM:605533 neuregulin 3 GO:0001558,GO:0005102,GO:0005576,GO:0005615,GO:0005622,GO:0005887,GO:0007389,GO:0008083,GO:0021842,GO:0030297,GO:0030971,GO:0035556,GO:0045499,GO:0048513,GO:0060596,GO:2001223 regulation of cell growth|receptor binding|extracellular region|extracellular space|intracellular|integral component of plasma membrane|pattern specification process|growth factor activity|chemorepulsion involved in interneuron migration from the subpallium to the cortex|transmembrane receptor protein tyrosine kinase activator activity|receptor tyrosine kinase binding|intracellular signal transduction|chemorepellent activity|animal organ development|mammary placode formation|negative regulation of neuron migration hsa04012 ErbB signaling pathway NRG4 16.0635978681911 19.0451410914363 13.0820546449458 0.686897229174544 -0.541833829979703 0.469050939063756 1 0.0253633 0.0168955 0.0169244 0.0210533 GeneID:145957,Genbank:XM_017021947.2,HGNC:HGNC:29862,MIM:610894 neuregulin 4 GO:0000165,GO:0004713,GO:0005088,GO:0005102,GO:0005576,GO:0005615,GO:0005622,GO:0005886,GO:0008083,GO:0016021,GO:0035556,GO:0038128,GO:0046934,GO:0048513,GO:0051897,GO:1901185,GO:2000145 MAPK cascade|protein tyrosine kinase activity|Ras guanyl-nucleotide exchange factor activity|receptor binding|extracellular region|extracellular space|intracellular|plasma membrane|growth factor activity|integral component of membrane|intracellular signal transduction|ERBB2 signaling pathway|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|animal organ development|positive regulation of protein kinase B signaling|negative regulation of ERBB signaling pathway|regulation of cell motility hsa04012 ErbB signaling pathway NRGN 258.893736569462 254.631147260562 263.156325878363 1.03348050193199 0.0475111705423809 0.858361441398415 1 8.61173 11.0221 11.5402 11.1931 GeneID:4900,Genbank:NM_001126181.1,HGNC:HGNC:8000,MIM:602350 neurogranin GO:0005516,GO:0005547,GO:0005634,GO:0007165,GO:0007399,GO:0008306,GO:0012510,GO:0014069,GO:0021537,GO:0030424,GO:0031966,GO:0043025,GO:0044327,GO:0070300,GO:1900273 calmodulin binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|signal transduction|nervous system development|associative learning|trans-Golgi network transport vesicle membrane|postsynaptic density|telencephalon development|axon|mitochondrial membrane|neuronal cell body|dendritic spine head|phosphatidic acid binding|positive regulation of long-term synaptic potentiation NRIP1 111.829029894878 123.802717249017 99.8553425407387 0.806568262471088 -0.310131456409137 0.522098399683655 1 0.595087 0.44057 0.556755 0.31148 GeneID:8204,Genbank:XM_011529752.1,HGNC:HGNC:8001,MIM:602490 nuclear receptor interacting protein 1 NRIP2 3.73626376988715 5.53486424558581 1.93766329418849 0.350083255562017 -1.51423003539272 0.371764102129441 1 0.0250188 0.079011 0 0.0329548 GeneID:83714,Genbank:XM_017020001.1,HGNC:HGNC:23078 nuclear receptor interacting protein 2 GO:0004190,GO:0005634,GO:0005737,GO:0006351,GO:0006355 aspartic-type endopeptidase activity|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated NRIP3 287.342172979688 271.792437983322 302.891907976054 1.11442360289156 0.156297718879153 0.445314575139054 1 2.46505 2.6635 3.00697 2.97171 GeneID:56675,Genbank:XM_024448608.1,HGNC:HGNC:1167,MIM:613125 nuclear receptor interacting protein 3 GO:0004190 aspartic-type endopeptidase activity NRL 46.1524727204965 45.7775371350276 46.5274083059655 1.01638076702829 0.0234409806461371 0.977283093022884 1 0.227998 0.2543 0.319854 0.256817 GeneID:4901,Genbank:NM_001354770.1,HGNC:HGNC:8002,MIM:162080 neural retina leucine zipper NRM 1060.104464101 993.914140739045 1126.29478746296 1.13319122980329 0.180391341307772 0.238585904024317 1 15.3645 16.4244 19.084 17.4636 GeneID:11270,Genbank:NM_007243.2,HGNC:HGNC:8003 nurim GO:0005635,GO:0005637,GO:0016020,GO:0016021,GO:0031965 nuclear envelope|nuclear inner membrane|membrane|integral component of membrane|nuclear membrane NRN1 1476.62235517461 1381.5819096458 1571.66280070342 1.13758206424862 0.185970623917048 0.200742205014269 1 18.9396 19.0266 22.8023 20.8804 GeneID:51299,Genbank:NM_001278710.1,HGNC:HGNC:17972,MIM:607409 neuritin 1 GO:0005576,GO:0005886,GO:0006501,GO:0007399,GO:0030054,GO:0031225,GO:0045202 extracellular region|plasma membrane|C-terminal protein lipidation|nervous system development|cell junction|anchored component of membrane|synapse NRN1L 1.97886065977503 2.98845468642911 0.969266633120943 0.324337068760816 -1.62443417482103 0.555345432940408 1 0 0.310946 0.109427 0 GeneID:123904,Genbank:NM_001348682.1,HGNC:HGNC:29811 neuritin 1 like GO:0005576,GO:0005615,GO:0005886,GO:0006501,GO:0030424,GO:0042803,GO:0046658,GO:0046982,GO:1990138 extracellular region|extracellular space|plasma membrane|C-terminal protein lipidation|axon|protein homodimerization activity|anchored component of plasma membrane|protein heterodimerization activity|neuron projection extension NRP1 3774.07973330454 3638.84527364424 3909.31419296484 1.07432822749557 0.103434831159707 0.433861900427999 1 18.7774 18.2435 21.9708 17.7581 GeneID:8829,Genbank:NM_001244973.1,HGNC:HGNC:8004,MIM:602069 neuropilin 1 GO:0001525,GO:0001569,GO:0001764,GO:0001938,GO:0002040,GO:0002042,GO:0002116,GO:0003148,GO:0005021,GO:0005096,GO:0005615,GO:0005769,GO:0005829,GO:0005883,GO:0005886,GO:0005925,GO:0006930,GO:0007165,GO:0007229,GO:0007267,GO:0007411,GO:0007413,GO:0008201,GO:0009611,GO:0009887,GO:0009986,GO:0010595,GO:0014911,GO:0015026,GO:0016021,GO:0016358,GO:0017154,GO:0019838,GO:0019901,GO:0019955,GO:0021612,GO:0021637,GO:0021649,GO:0021675,GO:0021785,GO:0021828,GO:0030424,GO:0030426,GO:0031290,GO:0031410,GO:0031532,GO:0032489,GO:0034446,GO:0035729,GO:0035767,GO:0035924,GO:0036486,GO:0038085,GO:0038189,GO:0038190,GO:0042327,GO:0043005,GO:0043025,GO:0043235,GO:0043524,GO:0043542,GO:0046872,GO:0048008,GO:0048010,GO:0048012,GO:0048842,GO:0048843,GO:0048844,GO:0048846,GO:0050731,GO:0050918,GO:0051491,GO:0051496,GO:0051894,GO:0060301,GO:0060385,GO:0060627,GO:0060666,GO:0060978,GO:0060982,GO:0061299,GO:0061441,GO:0061549,GO:0061551,GO:0070374,GO:0071526,GO:0071679,GO:0090050,GO:0090259,GO:0097102,GO:0097374,GO:0097443,GO:0097475,GO:0097490,GO:0097491,GO:0140059,GO:1900026,GO:1901166,GO:1901998,GO:1902285,GO:1902287,GO:1902336,GO:1902378,GO:1902946,GO:1903375,GO:1904835,GO:1905040,GO:2000251,GO:2001237 angiogenesis|branching involved in blood vessel morphogenesis|neuron migration|positive regulation of endothelial cell proliferation|sprouting angiogenesis|cell migration involved in sprouting angiogenesis|semaphorin receptor complex|outflow tract septum morphogenesis|vascular endothelial growth factor-activated receptor activity|GTPase activator activity|extracellular space|early endosome|cytosol|neurofilament|plasma membrane|focal adhesion|substrate-dependent cell migration, cell extension|signal transduction|integrin-mediated signaling pathway|cell-cell signaling|axon guidance|axonal fasciculation|heparin binding|response to wounding|animal organ morphogenesis|cell surface|positive regulation of endothelial cell migration|positive regulation of smooth muscle cell migration|coreceptor activity|integral component of membrane|dendrite development|semaphorin receptor activity|growth factor binding|protein kinase binding|cytokine binding|facial nerve structural organization|trigeminal nerve structural organization|vestibulocochlear nerve structural organization|nerve development|branchiomotor neuron axon guidance|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|axon|growth cone|retinal ganglion cell axon guidance|cytoplasmic vesicle|actin cytoskeleton reorganization|regulation of Cdc42 protein signal transduction|substrate adhesion-dependent cell spreading|cellular response to hepatocyte growth factor stimulus|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|ventral trunk neural crest cell migration|vascular endothelial growth factor binding|neuropilin signaling pathway|VEGF-activated neuropilin signaling pathway|positive regulation of phosphorylation|neuron projection|neuronal cell body|receptor complex|negative regulation of neuron apoptotic process|endothelial cell migration|metal ion binding|platelet-derived growth factor receptor signaling pathway|vascular endothelial growth factor receptor signaling pathway|hepatocyte growth factor receptor signaling pathway|positive regulation of axon extension involved in axon guidance|negative regulation of axon extension involved in axon guidance|artery morphogenesis|axon extension involved in axon guidance|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of filopodium assembly|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|positive regulation of cytokine activity|axonogenesis involved in innervation|regulation of vesicle-mediated transport|dichotomous subdivision of terminal units involved in salivary gland branching|angiogenesis involved in coronary vascular morphogenesis|coronary artery morphogenesis|retina vasculature morphogenesis in camera-type eye|renal artery morphogenesis|sympathetic ganglion development|trigeminal ganglion development|positive regulation of ERK1 and ERK2 cascade|semaphorin-plexin signaling pathway|commissural neuron axon guidance|positive regulation of cell migration involved in sprouting angiogenesis|regulation of retinal ganglion cell axon guidance|endothelial tip cell fate specification|sensory neuron axon guidance|sorting endosome|motor neuron migration|sympathetic neuron projection extension|sympathetic neuron projection guidance|dendrite arborization|positive regulation of substrate adhesion-dependent cell spreading|neural crest cell migration involved in autonomic nervous system development|toxin transport|semaphorin-plexin signaling pathway involved in neuron projection guidance|semaphorin-plexin signaling pathway involved in axon guidance|positive regulation of retinal ganglion cell axon guidance|VEGF-activated neuropilin signaling pathway involved in axon guidance|protein localization to early endosome|facioacoustic ganglion development|dorsal root ganglion morphogenesis|otic placode development|positive regulation of actin cytoskeleton reorganization|negative regulation of extrinsic apoptotic signaling pathway hsa04360,hsa05166 Axon guidance|Human T-cell leukemia virus 1 infection NRP2 11956.8877410256 12164.6285995025 11749.1468825486 0.965845096415778 -0.0501362687173312 0.692508354929372 1 27.0482 28.5634 28.6648 25.9295 GeneID:8828,Genbank:NM_201266.1,HGNC:HGNC:8005,MIM:602070 neuropilin 2 GO:0001525,GO:0001938,GO:0002116,GO:0003148,GO:0004872,GO:0005021,GO:0005576,GO:0005886,GO:0007155,GO:0007411,GO:0008201,GO:0010595,GO:0016020,GO:0016021,GO:0017154,GO:0019838,GO:0019955,GO:0021675,GO:0042802,GO:0046872,GO:0048010,GO:0048846,GO:0061549,GO:0097490,GO:0097491,GO:1902285 angiogenesis|positive regulation of endothelial cell proliferation|semaphorin receptor complex|outflow tract septum morphogenesis|receptor activity|vascular endothelial growth factor-activated receptor activity|extracellular region|plasma membrane|cell adhesion|axon guidance|heparin binding|positive regulation of endothelial cell migration|membrane|integral component of membrane|semaphorin receptor activity|growth factor binding|cytokine binding|nerve development|identical protein binding|metal ion binding|vascular endothelial growth factor receptor signaling pathway|axon extension involved in axon guidance|sympathetic ganglion development|sympathetic neuron projection extension|sympathetic neuron projection guidance|semaphorin-plexin signaling pathway involved in neuron projection guidance NRROS 2.2390998909608 2.05633815719933 2.42186162472226 1.1777545518198 0.236038907786066 1 1 0.043738 0.0376819 0.0201758 0.0755713 GeneID:375387,Genbank:NM_198565.2,HGNC:HGNC:24613,MIM:615322 negative regulator of reactive oxygen species GO:0005783,GO:0005789,GO:0005886,GO:0006801,GO:0006954,GO:0006955,GO:0016021,GO:0045087 endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|superoxide metabolic process|inflammatory response|immune response|integral component of membrane|innate immune response NRSN2 1671.4782492978 1582.85616002537 1760.10033857024 1.11197743864612 0.153127516943109 0.359323585146886 1 13.1167 15.4464 15.8187 16.8417 GeneID:80023,Genbank:NM_001323684.1,HGNC:HGNC:16229,MIM:610666 neurensin 2 GO:0005886,GO:0016021,GO:0030133,GO:0043025 plasma membrane|integral component of membrane|transport vesicle|neuronal cell body NRTN 54.5425166650271 46.0853120933532 62.9997212367011 1.36702386020702 0.451038424145096 0.270822613072336 1 2.51599 3.87709 4.35889 4.35413 GeneID:4902,Genbank:XM_011528041.2,HGNC:HGNC:8007,MIM:602018 neurturin GO:0000165,GO:0001755,GO:0005088,GO:0005102,GO:0005576,GO:0005622,GO:0007169,GO:0007399,GO:0007411,GO:0008083,GO:0021675,GO:0030424,GO:0031175 MAPK cascade|neural crest cell migration|Ras guanyl-nucleotide exchange factor activity|receptor binding|extracellular region|intracellular|transmembrane receptor protein tyrosine kinase signaling pathway|nervous system development|axon guidance|growth factor activity|nerve development|axon|neuron projection development NRXN1 1.70731027176878 1.96028560782945 1.45433493570811 0.741899511938183 -0.430704303521243 0.968964006615108 1 0 0.00624114 0.00311023 0 GeneID:9378,Genbank:NM_001330096.1,HGNC:HGNC:8008,MIM:600565 neurexin 1 GO:0005105,GO:0005246,GO:0005509,GO:0005730,GO:0005783,GO:0005886,GO:0006904,GO:0007268,GO:0007269,GO:0007416,GO:0007612,GO:0009986,GO:0010628,GO:0010629,GO:0010739,GO:0016021,GO:0030054,GO:0030534,GO:0031175,GO:0031965,GO:0031982,GO:0033130,GO:0033138,GO:0035176,GO:0042297,GO:0042734,GO:0043025,GO:0043234,GO:0045743,GO:0050839,GO:0050885,GO:0051897,GO:0051965,GO:0051968,GO:0060134,GO:0061178,GO:0070374,GO:0071625,GO:0090129,GO:0097104,GO:0097109,GO:0097116,GO:0097118,GO:0097119,GO:0099560,GO:1900020,GO:2000463,GO:2000821 type 1 fibroblast growth factor receptor binding|calcium channel regulator activity|calcium ion binding|nucleolus|endoplasmic reticulum|plasma membrane|vesicle docking involved in exocytosis|chemical synaptic transmission|neurotransmitter secretion|synapse assembly|learning|cell surface|positive regulation of gene expression|negative regulation of gene expression|positive regulation of protein kinase A signaling|integral component of membrane|cell junction|adult behavior|neuron projection development|nuclear membrane|vesicle|acetylcholine receptor binding|positive regulation of peptidyl-serine phosphorylation|social behavior|vocal learning|presynaptic membrane|neuronal cell body|protein complex|positive regulation of fibroblast growth factor receptor signaling pathway|cell adhesion molecule binding|neuromuscular process controlling balance|positive regulation of protein kinase B signaling|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|prepulse inhibition|regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of ERK1 and ERK2 cascade|vocalization behavior|positive regulation of synapse maturation|postsynaptic membrane assembly|neuroligin family protein binding|gephyrin clustering involved in postsynaptic density assembly|neuroligin clustering involved in postsynaptic membrane assembly|postsynaptic density protein 95 clustering|synaptic membrane adhesion|positive regulation of protein kinase C activity|positive regulation of excitatory postsynaptic potential|regulation of grooming behavior hsa04514 Cell adhesion molecules (CAMs) NRXN2 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0147777 0 0 0 GeneID:9379,Genbank:NM_138732.2,HGNC:HGNC:8009,MIM:600566 neurexin 2 GO:0004888,GO:0005246,GO:0005886,GO:0007158,GO:0007165,GO:0007268,GO:0007269,GO:0007416,GO:0016021,GO:0030534,GO:0035176,GO:0042297,GO:0043234,GO:0046872,GO:0050839,GO:0071625,GO:0097104,GO:0097109,GO:0097116,GO:0097118,GO:0097119,GO:0098793 transmembrane signaling receptor activity|calcium channel regulator activity|plasma membrane|neuron cell-cell adhesion|signal transduction|chemical synaptic transmission|neurotransmitter secretion|synapse assembly|integral component of membrane|adult behavior|social behavior|vocal learning|protein complex|metal ion binding|cell adhesion molecule binding|vocalization behavior|postsynaptic membrane assembly|neuroligin family protein binding|gephyrin clustering involved in postsynaptic density assembly|neuroligin clustering involved in postsynaptic membrane assembly|postsynaptic density protein 95 clustering|presynapse hsa04514 Cell adhesion molecules (CAMs) NRXN3 53.1684762811948 47.6897964681721 58.6471560942175 1.22976318704481 0.298380525508195 0.45989883663386 1 0.119062 0.132783 0.170159 0.132099 GeneID:9369,Genbank:XM_017021791.1,HGNC:HGNC:8010,MIM:600567 neurexin 3 GO:0001525,GO:0005576,GO:0005886,GO:0007155,GO:0016021 angiogenesis|extracellular region|plasma membrane|cell adhesion|integral component of membrane hsa04514 Cell adhesion molecules (CAMs) NSA2 2920.19527731601 3070.36484272885 2770.02571190316 0.902181289126947 -0.148510729428285 0.27927649088519 1 49.4405 50.0343 43.728 46.7157 GeneID:10412,Genbank:XM_011543098.1,HGNC:HGNC:30728,MIM:612497 NSA2, ribosome biogenesis homolog GO:0000460,GO:0000470,GO:0005730,GO:0030687 maturation of 5.8S rRNA|maturation of LSU-rRNA|nucleolus|preribosome, large subunit precursor NSD1 1680.6554136352 1766.68365168319 1594.62717558722 0.902610478150942 -0.147824568399162 0.415275998214788 1 4.38045 4.19976 4.46283 3.26163 GeneID:64324,Genbank:XM_024446158.1,HGNC:HGNC:14234,MIM:606681 nuclear receptor binding SET domain protein 1 hsa00310 Lysine degradation NSD2 8745.39553087905 8693.87374872624 8796.91731303186 1.01185243394186 0.0169989062936723 0.909720641313044 1 18.2356 19.4696 20.7698 17.7586 GeneID:7468,Genbank:NM_001042424.2,HGNC:HGNC:12766,MIM:602952 nuclear receptor binding SET domain protein 2 hsa00310,hsa05202 Lysine degradation|Transcriptional misregulation in cancer NSD3 839.839150518718 850.853542988782 828.824758048654 0.974109780559004 -0.0378437240754829 0.857900087239271 1 4.07596 4.06139 4.55893 3.31159 GeneID:54904,Genbank:NM_023034.1,HGNC:HGNC:12767,MIM:607083 nuclear receptor binding SET domain protein 3 hsa00310 Lysine degradation NSDHL 1081.02891332726 1116.29568705773 1045.7621395968 0.936814637663933 -0.0941644768618715 0.520417384369136 1 17.1988 18.4542 16.3313 17.8667 GeneID:50814,Genbank:NM_001129765.1,HGNC:HGNC:13398,MIM:300275 NAD(P) dependent steroid dehydrogenase-like GO:0000252,GO:0001942,GO:0003854,GO:0005783,GO:0005789,GO:0005811,GO:0006695,GO:0007224,GO:0016021,GO:0047012,GO:0060716,GO:0103066,GO:0103067 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|hair follicle development|3-beta-hydroxy-delta5-steroid dehydrogenase activity|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cholesterol biosynthetic process|smoothened signaling pathway|integral component of membrane|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity|labyrinthine layer blood vessel development|4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity|4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity hsa00100 Steroid biosynthesis NSF 1212.47670403376 1159.9482254498 1265.00518261772 1.09057038483522 0.125082883757534 0.411738097558049 1 10.5823 10.5561 13.2006 10.1125 GeneID:4905,Genbank:NM_006178.3,HGNC:HGNC:8016,MIM:601633 N-ethylmaleimide sensitive factor, vesicle fusing ATPase GO:0000139,GO:0000149,GO:0001921,GO:0005524,GO:0005765,GO:0005795,GO:0005829,GO:0005886,GO:0006813,GO:0006886,GO:0006887,GO:0006888,GO:0006890,GO:0014069,GO:0016192,GO:0016887,GO:0017075,GO:0017137,GO:0017157,GO:0019901,GO:0030165,GO:0032403,GO:0035255,GO:0035494,GO:0042623,GO:0043198,GO:0043209,GO:0045026,GO:0045732,GO:0046872,GO:0048208,GO:0070062 Golgi membrane|SNARE binding|positive regulation of receptor recycling|ATP binding|lysosomal membrane|Golgi stack|cytosol|plasma membrane|potassium ion transport|intracellular protein transport|exocytosis|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|postsynaptic density|vesicle-mediated transport|ATPase activity|syntaxin-1 binding|Rab GTPase binding|regulation of exocytosis|protein kinase binding|PDZ domain binding|protein complex binding|ionotropic glutamate receptor binding|SNARE complex disassembly|ATPase activity, coupled|dendritic shaft|myelin sheath|plasma membrane fusion|positive regulation of protein catabolic process|metal ion binding|COPII vesicle coating|extracellular exosome hsa04721,hsa04727,hsa04962 Synaptic vesicle cycle|GABAergic synapse|Vasopressin-regulated water reabsorption NSFL1C 1807.0156834455 1782.17484844794 1831.85651844306 1.02787698975686 0.039667621646197 0.789960175154221 1 9.18851 9.49303 9.66623 9.72055 GeneID:55968,Genbank:NM_018839.4,HGNC:HGNC:15912,MIM:606610 NSFL1 cofactor GO:0000045,GO:0005543,GO:0005634,GO:0005654,GO:0005694,GO:0005795,GO:0005829,GO:0005886,GO:0007030,GO:0019888,GO:0031468,GO:0043130,GO:0043161,GO:0045111,GO:0051117,GO:0061025,GO:1990730 autophagosome assembly|phospholipid binding|nucleus|nucleoplasm|chromosome|Golgi stack|cytosol|plasma membrane|Golgi organization|protein phosphatase regulator activity|nuclear envelope reassembly|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|intermediate filament cytoskeleton|ATPase binding|membrane fusion|VCP-NSFL1C complex hsa04141 Protein processing in endoplasmic reticulum NSG1 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0 0.0174223 0.0181456 0 GeneID:27065,Genbank:NM_001287763.1,HGNC:HGNC:18790,MIM:607645 neuronal vesicle trafficking associated 1 GO:0001881,GO:0001921,GO:0005102,GO:0005634,GO:0005737,GO:0005768,GO:0005770,GO:0005783,GO:0005789,GO:0006915,GO:0007212,GO:0016021,GO:0016197,GO:0016328,GO:0030425,GO:0030659,GO:0031901,GO:0032051,GO:0032580,GO:0032585,GO:0032588,GO:0036477,GO:0042982,GO:0043202,GO:0045211,GO:0048268,GO:0055038,GO:0098814,GO:0098845,GO:0098887,GO:0099627,GO:0099630,GO:1900271 receptor recycling|positive regulation of receptor recycling|receptor binding|nucleus|cytoplasm|endosome|late endosome|endoplasmic reticulum|endoplasmic reticulum membrane|apoptotic process|dopamine receptor signaling pathway|integral component of membrane|endosomal transport|lateral plasma membrane|dendrite|cytoplasmic vesicle membrane|early endosome membrane|clathrin light chain binding|Golgi cisterna membrane|multivesicular body membrane|trans-Golgi network membrane|somatodendritic compartment|amyloid precursor protein metabolic process|lysosomal lumen|postsynaptic membrane|clathrin coat assembly|recycling endosome membrane|spontaneous synaptic transmission|postsynaptic endosome|neurotransmitter receptor transport, endosome to postsynaptic membrane|neurotransmitter receptor cycle|postsynaptic neurotransmitter receptor cycle|regulation of long-term synaptic potentiation NSL1 740.840221618883 762.997508870322 718.682934367444 0.941920420463116 -0.0863229181204153 0.60862952774043 1 1.73702 1.6473 1.6228 1.619 GeneID:25936,Genbank:NM_001297736.1,HGNC:HGNC:24548,MIM:609174 NSL1, MIS12 kinetochore complex component GO:0000070,GO:0000444,GO:0000777,GO:0005654,GO:0005829,GO:0007062,GO:0016607,GO:0051301 mitotic sister chromatid segregation|MIS12/MIND type complex|condensed chromosome kinetochore|nucleoplasm|cytosol|sister chromatid cohesion|nuclear speck|cell division NSMAF 949.154969237988 979.452130053749 918.857808422227 0.938134473577389 -0.0921333592915612 0.549308597721206 1 7.94939 8.55543 7.95001 7.47934 GeneID:8439,Genbank:NM_003580.3,HGNC:HGNC:8017,MIM:603043 neutral sphingomyelinase activation associated factor GO:0005057,GO:0005737,GO:0005829,GO:0006672,GO:0007165,GO:0016230,GO:0043065,GO:2000304 signal transducer activity, downstream of receptor|cytoplasm|cytosol|ceramide metabolic process|signal transduction|sphingomyelin phosphodiesterase activator activity|positive regulation of apoptotic process|positive regulation of ceramide biosynthetic process hsa04071 Sphingolipid signaling pathway NSMCE1 554.746097866405 555.606338297262 553.885857435549 0.996903417504224 -0.00447435539652328 0.967198115180236 1 7.80273 8.92553 8.10745 9.31174 GeneID:197370,Genbank:NM_145080.3,HGNC:HGNC:29897,MIM:617263 NSE1 homolog, SMC5-SMC6 complex component GO:0000724,GO:0000781,GO:0004842,GO:0005634,GO:0005654,GO:0006301,GO:0016874,GO:0030915,GO:0035556,GO:0043231,GO:0046872,GO:0046983,GO:2001022 double-strand break repair via homologous recombination|chromosome, telomeric region|ubiquitin-protein transferase activity|nucleus|nucleoplasm|postreplication repair|ligase activity|Smc5-Smc6 complex|intracellular signal transduction|intracellular membrane-bounded organelle|metal ion binding|protein dimerization activity|positive regulation of response to DNA damage stimulus NSMCE2 545.122472283179 558.141922200456 532.103022365902 0.953347170676777 -0.0689264135896376 0.709498997055817 1 1.5717 1.46666 1.82669 1.58647 GeneID:286053,Genbank:XM_024447130.1,HGNC:HGNC:26513,MIM:617246 NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase GO:0000722,GO:0000724,GO:0000781,GO:0005634,GO:0005654,GO:0007049,GO:0008270,GO:0016604,GO:0016605,GO:0016874,GO:0019789,GO:0030915,GO:0034184,GO:0045842,GO:0051301,GO:0090398 telomere maintenance via recombination|double-strand break repair via homologous recombination|chromosome, telomeric region|nucleus|nucleoplasm|cell cycle|zinc ion binding|nuclear body|PML body|ligase activity|SUMO transferase activity|Smc5-Smc6 complex|positive regulation of maintenance of mitotic sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|cell division|cellular senescence NSMCE3 1062.34954818643 994.047393907138 1130.65170246571 1.13742232955478 0.185768032263453 0.212748599864402 1 24.7447 22.6496 28.3735 26.3874 GeneID:56160,Genbank:NM_138704.3,HGNC:HGNC:7677,MIM:608243 NSE3 homolog, SMC5-SMC6 complex component GO:0000781,GO:0005654,GO:0005737,GO:0006281,GO:0006310,GO:0030915,GO:0031398,GO:0034644,GO:0040008,GO:0046983,GO:0071478,GO:0072711 chromosome, telomeric region|nucleoplasm|cytoplasm|DNA repair|DNA recombination|Smc5-Smc6 complex|positive regulation of protein ubiquitination|cellular response to UV|regulation of growth|protein dimerization activity|cellular response to radiation|cellular response to hydroxyurea NSMCE4A 826.24993847282 843.137879072158 809.361997873482 0.95994026358317 -0.0589834641720801 0.709348469783285 1 12.113 12.3275 12.6965 11.2198 GeneID:54780,Genbank:NM_001167865.1,HGNC:HGNC:25935,MIM:612987 NSE4 homolog A, SMC5-SMC6 complex component GO:0000781,GO:0005654,GO:0006281,GO:0006310,GO:0016604,GO:0030915,GO:2001022 chromosome, telomeric region|nucleoplasm|DNA repair|DNA recombination|nuclear body|Smc5-Smc6 complex|positive regulation of response to DNA damage stimulus NSMF 2243.36571113202 2268.56951721305 2218.16190505098 0.977780001106605 -0.0324181972109646 0.782899752284847 1 19.2689 20.9151 20.7855 19.673 GeneID:26012,Genbank:NM_001130971.1,HGNC:HGNC:29843,MIM:608137 NMDA receptor synaptonuclear signaling and neuronal migration factor GO:0005634,GO:0005635,GO:0005654,GO:0005719,GO:0005737,GO:0014069,GO:0016020,GO:0016363,GO:0030054,GO:0030425,GO:0030863,GO:0031965,GO:0035307,GO:0043005,GO:0043204,GO:0043523,GO:0045202,GO:0045211,GO:0048168,GO:0048306,GO:0048814,GO:0071230,GO:0071257,GO:0071371,GO:0097440,GO:2001224 nucleus|nuclear envelope|nucleoplasm|nuclear euchromatin|cytoplasm|postsynaptic density|membrane|nuclear matrix|cell junction|dendrite|cortical cytoskeleton|nuclear membrane|positive regulation of protein dephosphorylation|neuron projection|perikaryon|regulation of neuron apoptotic process|synapse|postsynaptic membrane|regulation of neuronal synaptic plasticity|calcium-dependent protein binding|regulation of dendrite morphogenesis|cellular response to amino acid stimulus|cellular response to electrical stimulus|cellular response to gonadotropin stimulus|apical dendrite|positive regulation of neuron migration NSRP1 244.070838372496 261.317625097731 226.824051647262 0.868001351085412 -0.20423080659237 0.539302996946101 1 2.70339 1.93547 2.24262 1.85383 GeneID:84081,Genbank:NM_032141.3,HGNC:HGNC:25305,MIM:616173 nuclear speckle splicing regulatory protein 1 GO:0000381,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0006397,GO:0006913,GO:0008380,GO:0016607,GO:0030529,GO:0032502 regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|mRNA processing|nucleocytoplasmic transport|RNA splicing|nuclear speck|intracellular ribonucleoprotein complex|developmental process NSUN2 2845.35455030525 2998.50969408731 2692.19940652318 0.897845823821036 -0.155460365182919 0.252326197331983 1 30.9284 31.9752 30.1837 27.13 GeneID:54888,Genbank:NM_001193455.1,HGNC:HGNC:25994,MIM:610916 NOP2/Sun RNA methyltransferase family member 2 GO:0000049,GO:0003723,GO:0005654,GO:0005730,GO:0005737,GO:0005819,GO:0006400,GO:0007286,GO:0016428,GO:0030488,GO:0033313,GO:0033391,GO:0048820,GO:0051301 tRNA binding|RNA binding|nucleoplasm|nucleolus|cytoplasm|spindle|tRNA modification|spermatid development|tRNA (cytosine-5-)-methyltransferase activity|tRNA methylation|meiotic cell cycle checkpoint|chromatoid body|hair follicle maturation|cell division NSUN3 116.633883805768 124.706424813777 108.561342797759 0.87053528284427 -0.20002532331437 0.482707563092798 1 0.458318 0.461546 0.442676 0.368573 GeneID:63899,Genbank:NM_022072.4,HGNC:HGNC:26208,MIM:617491 NOP2/Sun RNA methyltransferase family member 3 GO:0000049,GO:0002127,GO:0005739,GO:0005759,GO:0005762,GO:0016428,GO:0031167,GO:0070129 tRNA binding|tRNA wobble base cytosine methylation|mitochondrion|mitochondrial matrix|mitochondrial large ribosomal subunit|tRNA (cytosine-5-)-methyltransferase activity|rRNA methylation|regulation of mitochondrial translation NSUN4 607.220218580722 606.697208613812 607.743228547632 1.00172412188316 0.0024852402772472 0.995562825146492 1 4.49577 4.55897 4.93219 4.24917 GeneID:387338,Genbank:NM_199044.3,HGNC:HGNC:31802,MIM:615394 NOP2/Sun RNA methyltransferase family member 4 GO:0005759,GO:0005762,GO:0008168,GO:0009383,GO:0031167,GO:0042256,GO:0070131,GO:0070181 mitochondrial matrix|mitochondrial large ribosomal subunit|methyltransferase activity|rRNA (cytosine-C5-)-methyltransferase activity|rRNA methylation|mature ribosome assembly|positive regulation of mitochondrial translation|small ribosomal subunit rRNA binding NSUN5 575.000421397643 626.626439959793 523.374402835494 0.835225533842899 -0.259762277393554 0.123806606165922 1 9.41506 8.74818 7.28955 7.74135 GeneID:55695,Genbank:NM_001168348.2,HGNC:HGNC:16385,MIM:615732 NOP2/Sun RNA methyltransferase family member 5 GO:0003723,GO:0005634,GO:0005730,GO:0008173,GO:0008757,GO:0070475 RNA binding|nucleus|nucleolus|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|rRNA base methylation NSUN6 101.321321249124 96.0137431623565 106.628899335891 1.11055871611614 0.15128567132722 0.617727833578806 1 0.313807 0.460783 0.55259 0.362734 GeneID:221078,Genbank:NM_001351116.1,HGNC:HGNC:23529,MIM:617199 NOP2/Sun RNA methyltransferase family member 6 GO:0000049,GO:0005737,GO:0005829,GO:0006400,GO:0016428 tRNA binding|cytoplasm|cytosol|tRNA modification|tRNA (cytosine-5-)-methyltransferase activity NSUN7 57.5484125513612 70.5114299512125 44.58539515151 0.632314437281431 -0.66128593475148 0.0792154174546106 0.945390555851746 0.232114 0.304344 0.166705 0.170405 GeneID:79730,Genbank:XM_017008611.2,HGNC:HGNC:25857,MIM:617185 NOP2/Sun RNA methyltransferase family member 7 GO:0003723,GO:0008168 RNA binding|methyltransferase activity NT5C 735.720138502926 733.873607747592 737.566669258261 1.00503228549396 0.00724184704986355 0.980451187893089 1 22.1395 22.7945 22.6182 25.2381 GeneID:30833,Genbank:NM_001252377.1,HGNC:HGNC:17144,MIM:191720 5', 3'-nucleotidase, cytosolic GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006195,GO:0008252,GO:0008253,GO:0009223,GO:0016311,GO:0019103,GO:0046135,GO:0046872,GO:0070062 nucleus|cytoplasm|mitochondrion|cytosol|purine nucleotide catabolic process|nucleotidase activity|5'-nucleotidase activity|pyrimidine deoxyribonucleotide catabolic process|dephosphorylation|pyrimidine nucleotide binding|pyrimidine nucleoside catabolic process|metal ion binding|extracellular exosome hsa00230,hsa00240,hsa00760 Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5C1B 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0158267 0 0 0 GeneID:93034,Genbank:NM_033253.3,HGNC:HGNC:17818,MIM:610526 5'-nucleotidase, cytosolic IB GO:0000166,GO:0000287,GO:0005634,GO:0005829,GO:0006195,GO:0008253 nucleotide binding|magnesium ion binding|nucleus|cytosol|purine nucleotide catabolic process|5'-nucleotidase activity hsa00230,hsa00240,hsa00760 Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5C2 2344.23936651916 2312.31505715193 2376.16367588639 1.02761242181812 0.0392962348094082 0.771524250786491 1 9.71866 9.64475 10.268 10.0037 GeneID:22978,Genbank:NM_001351181.1,HGNC:HGNC:8022,MIM:600417 5'-nucleotidase, cytosolic II GO:0000166,GO:0005829,GO:0006195,GO:0008253,GO:0017144,GO:0046040,GO:0046085,GO:0046872,GO:0050146 nucleotide binding|cytosol|purine nucleotide catabolic process|5'-nucleotidase activity|drug metabolic process|IMP metabolic process|adenosine metabolic process|metal ion binding|nucleoside phosphotransferase activity hsa00230,hsa00240,hsa00760 Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5C3A 499.463306433468 532.187755206932 466.738857660003 0.877019159297493 -0.189319734860961 0.291589451704865 1 8.97037 8.21513 8.65048 6.54424 GeneID:51251,Genbank:NM_001002010.3,HGNC:HGNC:17820,MIM:606224 5'-nucleotidase, cytosolic IIIA GO:0000166,GO:0000215,GO:0000287,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0006213,GO:0008253,GO:0009117,GO:0046085,GO:0046135,GO:0051607 nucleotide binding|tRNA 2'-phosphotransferase activity|magnesium ion binding|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|pyrimidine nucleoside metabolic process|5'-nucleotidase activity|nucleotide metabolic process|adenosine metabolic process|pyrimidine nucleoside catabolic process|defense response to virus hsa00230,hsa00240,hsa00760 Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5C3B 1951.97078480492 1943.21521759232 1960.72635201753 1.00901142306147 0.0129425073489737 0.95878886411725 1 30.8743 35.5883 34.6353 34.4222 GeneID:115024,Genbank:NM_052935.4,HGNC:HGNC:28300 5'-nucleotidase, cytosolic IIIB GO:0000166,GO:0000287,GO:0005829,GO:0008253,GO:0009117,GO:0043928 nucleotide binding|magnesium ion binding|cytosol|5'-nucleotidase activity|nucleotide metabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay hsa00230,hsa00240,hsa00760 Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5DC1 611.124801333484 600.988839578848 621.260763088122 1.03373094835418 0.0478607407936757 0.763083650104075 1 5.43679 5.57108 5.47094 5.58884 GeneID:221294,Genbank:XM_006715378.3,HGNC:HGNC:21556 5'-nucleotidase domain containing 1 GO:0008253,GO:0046872 5'-nucleotidase activity|metal ion binding NT5DC2 4941.33245596061 5047.57830050071 4835.0866114205 0.957902250063336 -0.0620496524374414 0.744680841445036 1 55.0825 56.9066 50.0662 59.5569 GeneID:64943,Genbank:NM_022908.2,HGNC:HGNC:25717 5'-nucleotidase domain containing 2 GO:0008253,GO:0046872 5'-nucleotidase activity|metal ion binding NT5DC3 946.605284515423 889.962185595147 1003.2483834357 1.12729327119084 0.172862888936876 0.255578641445464 1 4.37088 4.11409 5.2705 4.27661 GeneID:51559,Genbank:NM_001031701.2,HGNC:HGNC:30826,MIM:611076 5'-nucleotidase domain containing 3 GO:0008253,GO:0043235,GO:0046872 5'-nucleotidase activity|receptor complex|metal ion binding NT5DC4 5.58384635794556 7.29323609956755 3.87445661632358 0.5312397080568 -0.912565108451768 0.519641722851531 1 0.00668631 0 0 0 GeneID:284958,Genbank:XM_017005477.1,HGNC:HGNC:27678 5'-nucleotidase domain containing 4 GO:0008253,GO:0046872 5'-nucleotidase activity|metal ion binding NT5E 1018.98782128929 890.999146327999 1146.97649625058 1.28729247494514 0.364339873461648 0.498611917997631 1 9.44478 8.19326 15.7083 7.42795 GeneID:4907,Genbank:NM_002526.3,HGNC:HGNC:8021,MIM:129190 5'-nucleotidase ecto hsa00230,hsa00240,hsa00760 Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NT5M 51.0054276569083 42.404872251119 59.6059830626977 1.40563996301451 0.491227113550039 0.230235829722112 1 0.357795 0.330266 0.586313 0.430569 GeneID:56953,Genbank:NM_020201.3,HGNC:HGNC:15769,MIM:605292 5',3'-nucleotidase, mitochondrial GO:0000166,GO:0005739,GO:0005759,GO:0006260,GO:0008252,GO:0008253,GO:0009223,GO:0046079,GO:0046135,GO:0046872 nucleotide binding|mitochondrion|mitochondrial matrix|DNA replication|nucleotidase activity|5'-nucleotidase activity|pyrimidine deoxyribonucleotide catabolic process|dUMP catabolic process|pyrimidine nucleoside catabolic process|metal ion binding hsa00230,hsa00240,hsa00760 Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism NTAN1 979.388219245332 905.673896423106 1053.10254206756 1.16278336631619 0.217582338897771 0.157949971093713 1 16.6856 17.3956 20.8413 19.5484 GeneID:123803,Genbank:NM_001270767.1,HGNC:HGNC:29909,MIM:615367 N-terminal asparagine amidase GO:0005634,GO:0005737,GO:0006511,GO:0007613,GO:0008344,GO:0008418 nucleus|cytoplasm|ubiquitin-dependent protein catabolic process|memory|adult locomotory behavior|protein-N-terminal asparagine amidohydrolase activity NTF4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0199262 0 GeneID:4909,Genbank:XM_005258962.3,HGNC:HGNC:8024,MIM:162662 neurotrophin 4 GO:0005166,GO:0005576,GO:0007169,GO:0007267,GO:0007402,GO:0007616,GO:0008052,GO:0008083,GO:0008344,GO:0008544,GO:0031410,GO:0042490,GO:0043524,GO:0045664,GO:0048812,GO:0060384,GO:0061193 neurotrophin p75 receptor binding|extracellular region|transmembrane receptor protein tyrosine kinase signaling pathway|cell-cell signaling|ganglion mother cell fate determination|long-term memory|sensory organ boundary specification|growth factor activity|adult locomotory behavior|epidermis development|cytoplasmic vesicle|mechanoreceptor differentiation|negative regulation of neuron apoptotic process|regulation of neuron differentiation|neuron projection morphogenesis|innervation|taste bud development hsa04010,hsa04014,hsa04151,hsa04722 MAPK signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Neurotrophin signaling pathway NTHL1 358.098213865715 384.718548840762 331.477878890668 0.861611377692812 -0.214890793899603 0.250536432120498 1 9.82099 10.5009 8.09827 8.67094 GeneID:4913,Genbank:XM_017023253.1,HGNC:HGNC:8028,MIM:602656 nth like DNA glycosylase 1 hsa03410 Base excision repair NTM 297.890199424317 304.030272307176 291.750126541457 0.959608805818812 -0.0594816983514276 0.799986753792951 1 1.09961 0.904633 1.0324 0.939972 GeneID:50863,Genbank:XM_017017852.2,HGNC:HGNC:17941,MIM:607938 neurotrimin GO:0005576,GO:0005886,GO:0006501,GO:0007155,GO:0008038,GO:0031225 extracellular region|plasma membrane|C-terminal protein lipidation|cell adhesion|neuron recognition|anchored component of membrane NTMT1 1090.14780919247 1082.21221998478 1098.08339840015 1.01466549547518 0.021004192870843 0.909211747800364 1 12.458 13.0639 12.5926 13.8447 GeneID:28989,Genbank:NM_001286796.1,HGNC:HGNC:23373,MIM:613560 N-terminal Xaa-Pro-Lys N-methyltransferase 1 GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007051,GO:0007059,GO:0008276,GO:0016571,GO:0018011,GO:0018012,GO:0018013,GO:0018016,GO:0035572,GO:0035573,GO:0042054,GO:0071885 nucleus|nucleoplasm|cytoplasm|cytosol|spindle organization|chromosome segregation|protein methyltransferase activity|histone methylation|N-terminal peptidyl-alanine methylation|N-terminal peptidyl-alanine trimethylation|N-terminal peptidyl-glycine methylation|N-terminal peptidyl-proline dimethylation|N-terminal peptidyl-serine dimethylation|N-terminal peptidyl-serine trimethylation|histone methyltransferase activity|N-terminal protein N-methyltransferase activity NTN1 1089.699515997 887.310931832367 1292.08810016163 1.45618413321401 0.542192794601533 0.000340307581736889 0.0488987647139116 7.35661 7.16247 11.8419 10.0244 GeneID:9423,Genbank:NM_004822.2,HGNC:HGNC:8029,MIM:601614 netrin 1 GO:0001764,GO:0005576,GO:0005604,GO:0005737,GO:0006915,GO:0006930,GO:0007097,GO:0007265,GO:0007411,GO:0008284,GO:0030334,GO:0030517,GO:0032488,GO:0033564,GO:0042472,GO:0045773,GO:0060603,GO:0098609,GO:2000147 neuron migration|extracellular region|basement membrane|cytoplasm|apoptotic process|substrate-dependent cell migration, cell extension|nuclear migration|Ras protein signal transduction|axon guidance|positive regulation of cell proliferation|regulation of cell migration|negative regulation of axon extension|Cdc42 protein signal transduction|anterior/posterior axon guidance|inner ear morphogenesis|positive regulation of axon extension|mammary gland duct morphogenesis|cell-cell adhesion|positive regulation of cell motility hsa04360 Axon guidance NTN3 4.52589943705493 3.71865746181119 5.33314141229868 1.43415774834533 0.520203720161655 0.755054611264821 1 0.26032 0 0.157415 0.110253 GeneID:4917,Genbank:NM_006181.2,HGNC:HGNC:8030,MIM:602349 netrin 3 GO:0005102,GO:0005578,GO:0005794,GO:0007411 receptor binding|proteinaceous extracellular matrix|Golgi apparatus|axon guidance hsa04360 Axon guidance NTN4 1275.1044592298 1025.85400875968 1524.35490969992 1.48593746935098 0.571373406216106 0.0146737948039626 0.505409672215622 10.3519 10.1055 17.8451 12.7247 GeneID:59277,Genbank:NM_001329701.1,HGNC:HGNC:13658,MIM:610401 netrin 4 GO:0005604,GO:0005886,GO:0007411,GO:0016322,GO:0043237,GO:0060668 basement membrane|plasma membrane|axon guidance|neuron remodeling|laminin-1 binding|regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling hsa04360 Axon guidance NTN5 7.28952505208265 8.76345030543964 5.81559979872566 0.663619875280836 -0.591570999522302 0.631757703008623 1 0.106562 0.0918537 0.0492827 0.076812 GeneID:126147,Genbank:NM_145807.2,HGNC:HGNC:25208 netrin 5 GO:0005576 extracellular region NTNG1 482.650256873602 426.872464062493 538.42804968471 1.2613323533698 0.334948467087433 0.0529688955671886 0.840383088256616 1.39256 1.15416 1.68643 1.57232 GeneID:22854,Genbank:NM_001312688.1,HGNC:HGNC:23319,MIM:608818 netrin G1 GO:0005576,GO:0005886,GO:0006501,GO:0007409,GO:0046658 extracellular region|plasma membrane|C-terminal protein lipidation|axonogenesis|anchored component of plasma membrane hsa04360,hsa04514 Axon guidance|Cell adhesion molecules (CAMs) NTNG2 34.1475563603153 39.2145038108421 29.0806089097885 0.741577887866789 -0.431329868103705 0.394224631713707 1 0.216147 0.128062 0.161952 0.0993058 GeneID:84628,Genbank:XM_011519096.2,HGNC:HGNC:14288 netrin G2 GO:0005576,GO:0005829,GO:0005886,GO:0006501,GO:0007409,GO:0030424,GO:0045171,GO:0046658,GO:0090543 extracellular region|cytosol|plasma membrane|C-terminal protein lipidation|axonogenesis|axon|intercellular bridge|anchored component of plasma membrane|Flemming body hsa04360,hsa04514 Axon guidance|Cell adhesion molecules (CAMs) NTPCR 489.608898596323 474.275119883411 504.942677309235 1.06466195703743 0.0903954301490573 0.625006074603469 1 11.3903 12.0488 12.4581 13.6047 GeneID:84284,Genbank:NM_001329452.1,HGNC:HGNC:28204 nucleoside-triphosphatase, cancer-related GO:0003723,GO:0005524,GO:0016020,GO:0017111,GO:0070062,GO:0098519 RNA binding|ATP binding|membrane|nucleoside-triphosphatase activity|extracellular exosome|nucleotide phosphatase activity, acting on free nucleotides hsa00230,hsa00730 Purine metabolism|Thiamine metabolism NTRK1 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:4914,Genbank:NM_001007792.1,HGNC:HGNC:8031,MIM:191315 neurotrophic receptor tyrosine kinase 1 GO:0000186,GO:0001934,GO:0004713,GO:0004714,GO:0005004,GO:0005166,GO:0005524,GO:0005768,GO:0005769,GO:0005770,GO:0005886,GO:0005887,GO:0006468,GO:0007018,GO:0007411,GO:0007568,GO:0007611,GO:0007623,GO:0008285,GO:0009314,GO:0009986,GO:0010465,GO:0010623,GO:0010976,GO:0018108,GO:0019900,GO:0021553,GO:0030183,GO:0030424,GO:0030425,GO:0031667,GO:0031901,GO:0031902,GO:0038083,GO:0038180,GO:0042490,GO:0042803,GO:0043025,GO:0043066,GO:0043068,GO:0043121,GO:0043234,GO:0043235,GO:0043524,GO:0043547,GO:0045766,GO:0046579,GO:0046777,GO:0048011,GO:0048015,GO:0048406,GO:0048485,GO:0048678,GO:0050965,GO:0050966,GO:0051092,GO:0051599,GO:0051602,GO:0051965,GO:0051968,GO:0060009,GO:0060385,GO:0061368,GO:0070374,GO:0071316,GO:1990090 activation of MAPKK activity|positive regulation of protein phosphorylation|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|GPI-linked ephrin receptor activity|neurotrophin p75 receptor binding|ATP binding|endosome|early endosome|late endosome|plasma membrane|integral component of plasma membrane|protein phosphorylation|microtubule-based movement|axon guidance|aging|learning or memory|circadian rhythm|negative regulation of cell proliferation|response to radiation|cell surface|nerve growth factor receptor activity|programmed cell death involved in cell development|positive regulation of neuron projection development|peptidyl-tyrosine phosphorylation|kinase binding|olfactory nerve development|B cell differentiation|axon|dendrite|response to nutrient levels|early endosome membrane|late endosome membrane|peptidyl-tyrosine autophosphorylation|nerve growth factor signaling pathway|mechanoreceptor differentiation|protein homodimerization activity|neuronal cell body|negative regulation of apoptotic process|positive regulation of programmed cell death|neurotrophin binding|protein complex|receptor complex|negative regulation of neuron apoptotic process|positive regulation of GTPase activity|positive regulation of angiogenesis|positive regulation of Ras protein signal transduction|protein autophosphorylation|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|nerve growth factor binding|sympathetic nervous system development|response to axon injury|detection of temperature stimulus involved in sensory perception of pain|detection of mechanical stimulus involved in sensory perception of pain|positive regulation of NF-kappaB transcription factor activity|response to hydrostatic pressure|response to electrical stimulus|positive regulation of synapse assembly|positive regulation of synaptic transmission, glutamatergic|Sertoli cell development|axonogenesis involved in innervation|behavioral response to formalin induced pain|positive regulation of ERK1 and ERK2 cascade|cellular response to nicotine|cellular response to nerve growth factor stimulus hsa04010,hsa04014,hsa04151,hsa04210,hsa04722,hsa04750,hsa05200,hsa05202,hsa05216,hsa05230 MAPK signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer|Central carbon metabolism in cancer NTRK2 7.90552230598115 6.12098819691306 9.69005641504924 1.58308693029928 0.662740478765213 0.563661458701359 1 0.00866943 0.0143952 0.0145336 0.0213067 GeneID:4915,Genbank:NM_006180.4,HGNC:HGNC:8032,MIM:600456 neurotrophic receptor tyrosine kinase 2 hsa04010,hsa04014,hsa04151,hsa04722,hsa05034 MAPK signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Neurotrophin signaling pathway|Alcoholism NTRK3 659.932392377224 688.355819296205 631.508965458243 0.917416469441512 -0.124351288003437 0.434205012655738 1 0.630577 0.747538 0.715183 0.591297 GeneID:4916,Genbank:XM_017022240.1,HGNC:HGNC:8033,MIM:191316 neurotrophic receptor tyrosine kinase 3 GO:0004714,GO:0005030,GO:0005524,GO:0005887,GO:0007169,GO:0007399,GO:0007507,GO:0030154 transmembrane receptor protein tyrosine kinase activity|neurotrophin receptor activity|ATP binding|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|nervous system development|heart development|cell differentiation hsa04722,hsa05230 Neurotrophin signaling pathway|Central carbon metabolism in cancer NTS 2.18226400914047 0.490071401957362 3.87445661632358 7.90590228454235 2.98293012382975 0.333315003612178 1 0 0 0.0366417 0.170355 GeneID:4922,Genbank:NM_006183.4,HGNC:HGNC:8038,MIM:162650 neurotensin hsa04080 Neuroactive ligand-receptor interaction NUAK1 953.523611750806 939.219265819416 967.827957682196 1.03046007775173 0.0432886128390537 0.789735323305842 1 6.05491 6.23991 6.77889 6.05251 GeneID:9891,Genbank:NM_014840.2,HGNC:HGNC:14311,MIM:608130 NUAK family kinase 1 GO:0001650,GO:0002039,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0006974,GO:0007155,GO:0015630,GO:0030155,GO:0035507,GO:0035556,GO:0042127,GO:0046872,GO:1901796,GO:2000772 fibrillar center|p53 binding|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|cellular response to DNA damage stimulus|cell adhesion|microtubule cytoskeleton|regulation of cell adhesion|regulation of myosin-light-chain-phosphatase activity|intracellular signal transduction|regulation of cell proliferation|metal ion binding|regulation of signal transduction by p53 class mediator|regulation of cellular senescence NUAK2 730.355678299323 718.268775124965 742.442581473681 1.03365565535619 0.0477556565925158 0.789377937316812 1 8.04648 8.58696 8.67108 8.64892 GeneID:81788,Genbank:XM_005245515.4,HGNC:HGNC:29558,MIM:608131 NUAK family kinase 2 GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0006915,GO:0030036,GO:0035556,GO:0042149,GO:0043066 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|apoptotic process|actin cytoskeleton organization|intracellular signal transduction|cellular response to glucose starvation|negative regulation of apoptotic process NUB1 1687.84368088478 1714.32346391376 1661.36389785581 0.969107600069213 -0.0452712378454485 0.764734455206151 1 14.0418 13.7607 14.2526 12.4692 GeneID:51667,Genbank:XM_017012307.1,HGNC:HGNC:17623,MIM:607981 negative regulator of ubiquitin like proteins 1 GO:0005634,GO:0005829,GO:0006511,GO:0016567,GO:0032436,GO:0034341,GO:0034612,GO:0043687 nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|response to interferon-gamma|response to tumor necrosis factor|post-translational protein modification NUBP1 650.282943522092 701.096658746241 599.469228297942 0.855045050949125 -0.225927659603885 0.170056679528072 1 9.01197 8.9057 8.05203 7.87703 GeneID:4682,Genbank:XM_017023252.1,HGNC:HGNC:8041,MIM:600280 nucleotide binding protein 1 GO:0000166,GO:0005524,GO:0005634,GO:0005814,GO:0005829,GO:0005886,GO:0005929,GO:0006879,GO:0010826,GO:0016049,GO:0016226,GO:0030030,GO:0046872,GO:0051536,GO:0051539,GO:0051642,GO:0070062,GO:0072697 nucleotide binding|ATP binding|nucleus|centriole|cytosol|plasma membrane|cilium|cellular iron ion homeostasis|negative regulation of centrosome duplication|cell growth|iron-sulfur cluster assembly|cell projection organization|metal ion binding|iron-sulfur cluster binding|4 iron, 4 sulfur cluster binding|centrosome localization|extracellular exosome|protein localization to cell cortex NUBP2 986.353341581439 1011.24116159779 961.465521565092 0.950777676064879 -0.0728200651961925 0.689023059169871 1 13.6039 15.9923 14.3528 14.9836 GeneID:10101,Genbank:NM_001284501.1,HGNC:HGNC:8042,MIM:610779 nucleotide binding protein 2 GO:0000166,GO:0005524,GO:0005634,GO:0005814,GO:0005929,GO:0016226,GO:0030030,GO:0031616,GO:0046872,GO:0051539 nucleotide binding|ATP binding|nucleus|centriole|cilium|iron-sulfur cluster assembly|cell projection organization|spindle pole centrosome|metal ion binding|4 iron, 4 sulfur cluster binding NUBPL 183.146878726598 186.492622079127 179.801135374068 0.964119295281185 -0.0527164255459037 0.841355732502501 1 0.516211 0.487564 0.54918 0.476234 GeneID:80224,Genbank:NM_025152.2,HGNC:HGNC:20278,MIM:613621 nucleotide binding protein like GO:0005524,GO:0005739,GO:0005759,GO:0005886,GO:0032981,GO:0046872,GO:0051539,GO:0070584 ATP binding|mitochondrion|mitochondrial matrix|plasma membrane|mitochondrial respiratory chain complex I assembly|metal ion binding|4 iron, 4 sulfur cluster binding|mitochondrion morphogenesis NUCB1 5464.05943910984 5270.89493831239 5657.22393990729 1.07329476419399 0.102046344911437 0.477181540337546 1 56.626 61.1501 61.7291 67.0888 GeneID:4924,Genbank:NM_006184.5,HGNC:HGNC:8043,MIM:601323 nucleobindin 1 GO:0001965,GO:0003677,GO:0005509,GO:0005615,GO:0005634,GO:0005769,GO:0005788,GO:0005791,GO:0005793,GO:0005798,GO:0005801,GO:0005802,GO:0016020,GO:0032580,GO:0043687,GO:0044267,GO:0070062,GO:0072718,GO:0090498,GO:0098547,GO:1903533 G-protein alpha-subunit binding|DNA binding|calcium ion binding|extracellular space|nucleus|early endosome|endoplasmic reticulum lumen|rough endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi-associated vesicle|cis-Golgi network|trans-Golgi network|membrane|Golgi cisterna membrane|post-translational protein modification|cellular protein metabolic process|extracellular exosome|response to cisplatin|extrinsic component of Golgi membrane|lumenal side of Golgi membrane|regulation of protein targeting NUCB2 337.032757493565 318.808849605051 355.25666538208 1.11432498132402 0.156170041089464 0.399548070974001 1 2.42253 2.03411 2.72596 2.24997 GeneID:4925,Genbank:XM_024448537.1,HGNC:HGNC:8044,MIM:608020 nucleobindin 2 GO:0003677,GO:0005509,GO:0005615,GO:0005635,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0005886,GO:0070062 DNA binding|calcium ion binding|extracellular space|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|plasma membrane|extracellular exosome NUCKS1 9563.09269222453 10680.6633297637 8445.5220546853 0.79073010672944 -0.338742739160563 0.0104586667751202 0.411562670934461 74.086 67.5874 60.6213 51.2791 GeneID:64710,Genbank:NM_022731.4,HGNC:HGNC:29923,MIM:611912 nuclear casein kinase and cyclin dependent kinase substrate 1 GO:0000724,GO:0000785,GO:0000790,GO:0001077,GO:0001678,GO:0003682,GO:0003690,GO:0003697,GO:0003723,GO:0005634,GO:0005730,GO:0005737,GO:0006275,GO:0006325,GO:0006357,GO:0008134,GO:0019046,GO:0031297,GO:0035822,GO:0036297,GO:0043923,GO:0044829,GO:0046626,GO:0046628,GO:0060382,GO:0071481,GO:1990968,GO:1990969 double-strand break repair via homologous recombination|chromatin|nuclear chromatin|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|cellular glucose homeostasis|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|RNA binding|nucleus|nucleolus|cytoplasm|regulation of DNA replication|chromatin organization|regulation of transcription from RNA polymerase II promoter|transcription factor binding|release from viral latency|replication fork processing|gene conversion|interstrand cross-link repair|positive regulation by host of viral transcription|positive regulation by host of viral genome replication|regulation of insulin receptor signaling pathway|positive regulation of insulin receptor signaling pathway|regulation of DNA strand elongation|cellular response to X-ray|modulation by host of RNA binding by virus|modulation by host of viral RNA-binding transcription factor activity NUDC 4049.95986551059 4003.47394600731 4096.44578501387 1.02322279107106 0.0331203040067408 0.811324408883232 1 39.1349 41.1273 41.8857 42.2313 GeneID:10726,Genbank:XM_024452486.1,HGNC:HGNC:8045,MIM:610325 nuclear distribution C, dynein complex regulator GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0006457,GO:0007062,GO:0007275,GO:0008283,GO:0045296,GO:0051082,GO:0051301 nucleoplasm|cytoplasm|cytosol|microtubule|protein folding|sister chromatid cohesion|multicellular organism development|cell proliferation|cadherin binding|unfolded protein binding|cell division NUDCD1 408.03913673826 424.431915707815 391.646357768706 0.922754258749761 -0.115981603990055 0.678710464642653 1 3.26289 3.0077 3.49167 2.17928 GeneID:84955,Genbank:NM_032869.3,HGNC:HGNC:24306,MIM:606109 NudC domain containing 1 GO:0002376,GO:0005654,GO:0005829 immune system process|nucleoplasm|cytosol NUDCD2 1081.07842526229 1080.48225709527 1081.67459342932 1.00110352236348 0.001591168457702 1 1 4.49244 5.27065 4.708 4.69838 GeneID:134492,Genbank:NM_145266.5,HGNC:HGNC:30535 NudC domain containing 2 GO:0000777,GO:0000922,GO:0005622,GO:0005737,GO:0005815,GO:0006457,GO:0032502,GO:0051082,GO:0070062 condensed chromosome kinetochore|spindle pole|intracellular|cytoplasm|microtubule organizing center|protein folding|developmental process|unfolded protein binding|extracellular exosome NUDCD3 2878.99353278606 2324.04937883529 3433.93768673682 1.4775665775474 0.563223138141189 4.13646007024995e-05 0.0129901067617888 13.7351 14.5169 21.217 22.2635 GeneID:23386,Genbank:NM_015332.3,HGNC:HGNC:22208,MIM:610296 NudC domain containing 3 GO:0005737,GO:0005868,GO:0006457,GO:0032502,GO:0051082,GO:0060271,GO:1905793 cytoplasm|cytoplasmic dynein complex|protein folding|developmental process|unfolded protein binding|cilium assembly|protein localization to pericentriolar material NUDT1 1081.85599514249 1113.14353623703 1050.56845404795 0.943785253067527 -0.0834694657865877 0.633652817504451 1 46.7815 48.1755 41.2033 48.71 GeneID:4521,Genbank:NM_198949.1,HGNC:HGNC:8048,MIM:600312 nudix hydrolase 1 NUDT10 3.50980312085405 4.11267631439867 2.90692992730943 0.706821958521787 -0.500581234739772 0.84452534115427 1 0.0862084 0.0797686 0.0409797 0.0764444 GeneID:170685,Genbank:NM_153183.3,HGNC:HGNC:17621,MIM:300527 nudix hydrolase 10 GO:0000298,GO:0005634,GO:0005737,GO:0005829,GO:0008486,GO:0034431,GO:0034432,GO:0043647,GO:0046872,GO:0050072,GO:0052840,GO:0052841,GO:0052842,GO:0052843,GO:0052844,GO:0052845,GO:0052846,GO:0052847,GO:0052848,GO:0071543,GO:1901907,GO:1901909,GO:1901911 endopolyphosphatase activity|nucleus|cytoplasm|cytosol|diphosphoinositol-polyphosphate diphosphatase activity|bis(5'-adenosyl)-hexaphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|inositol phosphate metabolic process|metal ion binding|m7G(5')pppN diphosphatase activity|inositol diphosphate tetrakisphosphate diphosphatase activity|inositol bisdiphosphate tetrakisphosphate diphosphatase activity|inositol diphosphate pentakisphosphate diphosphatase activity|inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity|inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity|inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity|inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity|diphosphoinositol polyphosphate metabolic process|diadenosine pentaphosphate catabolic process|diadenosine hexaphosphate catabolic process|adenosine 5'-(hexahydrogen pentaphosphate) catabolic process NUDT11 71.0456142753045 90.228938888238 51.8622896623709 0.574785543323413 -0.798904318474687 0.0220840362563282 0.604611837062141 2.15035 1.77418 1.33931 0.893727 GeneID:55190,Genbank:NM_018159.3,HGNC:HGNC:18011,MIM:300528 nudix hydrolase 11 GO:0000298,GO:0005622,GO:0005634,GO:0005737,GO:0005829,GO:0008486,GO:0034431,GO:0034432,GO:0043647,GO:0046872,GO:0050072,GO:0052840,GO:0052841,GO:0052842,GO:0052843,GO:0052844,GO:0052845,GO:0052846,GO:0052847,GO:0052848,GO:0071543,GO:1901907,GO:1901909,GO:1901911 endopolyphosphatase activity|intracellular|nucleus|cytoplasm|cytosol|diphosphoinositol-polyphosphate diphosphatase activity|bis(5'-adenosyl)-hexaphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|inositol phosphate metabolic process|metal ion binding|m7G(5')pppN diphosphatase activity|inositol diphosphate tetrakisphosphate diphosphatase activity|inositol bisdiphosphate tetrakisphosphate diphosphatase activity|inositol diphosphate pentakisphosphate diphosphatase activity|inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity|inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity|inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity|inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity|diphosphoinositol polyphosphate metabolic process|diadenosine pentaphosphate catabolic process|diadenosine hexaphosphate catabolic process|adenosine 5'-(hexahydrogen pentaphosphate) catabolic process NUDT12 152.083071308039 159.26034597847 144.905796637608 0.909867398236072 -0.136271788967927 0.616583902384712 1 2.0187 1.74878 1.78006 1.70495 GeneID:83594,Genbank:XM_005272097.3,HGNC:HGNC:18826,MIM:609232 nudix hydrolase 12 GO:0000210,GO:0005634,GO:0005777,GO:0005782,GO:0006742,GO:0019677,GO:0034356,GO:0035529,GO:0046872 NAD+ diphosphatase activity|nucleus|peroxisome|peroxisomal matrix|NADP catabolic process|NAD catabolic process|NAD biosynthesis via nicotinamide riboside salvage pathway|NADH pyrophosphatase activity|metal ion binding hsa00760,hsa04146 Nicotinate and nicotinamide metabolism|Peroxisome NUDT13 3.75821034357122 5.09281911831339 2.42360156882906 0.475886049067396 -1.07131193338391 0.544084998342287 1 0 0.0186451 0.0188658 0.0351181 GeneID:25961,Genbank:NM_001283016.1,HGNC:HGNC:18827,MIM:609233 nudix hydrolase 13 GO:0005759,GO:0015949,GO:0016462,GO:0046872 mitochondrial matrix|nucleobase-containing small molecule interconversion|pyrophosphatase activity|metal ion binding NUDT14 233.950417275842 206.710011073218 261.190823478466 1.26356155719014 0.337495950067936 0.115173904517836 1 4.56064 3.9451 5.19427 6.44215 GeneID:256281,Genbank:NM_177533.4,HGNC:HGNC:20141,MIM:609219 nudix hydrolase 14 GO:0005829,GO:0008768,GO:0018279,GO:0042802,GO:0046872,GO:0047631,GO:0070062 cytosol|UDP-sugar diphosphatase activity|protein N-linked glycosylation via asparagine|identical protein binding|metal ion binding|ADP-ribose diphosphatase activity|extracellular exosome NUDT15 828.604453736985 825.120907059322 832.088000414647 1.00844372418117 0.0121305771486318 0.944691740736639 1 12.4334 13.5717 13.2586 13.2317 GeneID:55270,Genbank:NM_018283.3,HGNC:HGNC:23063,MIM:615792 nudix hydrolase 15 GO:0000278,GO:0005829,GO:0006195,GO:0006203,GO:0008413,GO:0017110,GO:0034656,GO:0035529,GO:0035539,GO:0042262,GO:0042738,GO:0046872,GO:0047429,GO:0061136,GO:1901292 mitotic cell cycle|cytosol|purine nucleotide catabolic process|dGTP catabolic process|8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity|nucleoside-diphosphatase activity|nucleobase-containing small molecule catabolic process|NADH pyrophosphatase activity|8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity|DNA protection|exogenous drug catabolic process|metal ion binding|nucleoside-triphosphate diphosphatase activity|regulation of proteasomal protein catabolic process|nucleoside phosphate catabolic process NUDT16 623.054192936559 626.270638726783 619.837747146336 0.989728256152124 -0.0148956275914107 0.938997643237972 1 2.94106 2.95216 3.00894 2.88204 GeneID:131870,Genbank:NM_001171905.1,HGNC:HGNC:26442,MIM:617381 nudix hydrolase 16 GO:0000287,GO:0003729,GO:0005525,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006382,GO:0006402,GO:0008235,GO:0008284,GO:0016077,GO:0030145,GO:0030515,GO:0034656,GO:0035863,GO:0035870,GO:0042802,GO:0042803,GO:0046709,GO:0050072,GO:0050897,GO:0090068,GO:0097383,GO:0098519,GO:1901639,GO:1901640,GO:1901641,GO:1990003,GO:2000233,GO:2000781 magnesium ion binding|mRNA binding|GTP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|adenosine to inosine editing|mRNA catabolic process|metalloexopeptidase activity|positive regulation of cell proliferation|snoRNA catabolic process|manganese ion binding|snoRNA binding|nucleobase-containing small molecule catabolic process|dITP catabolic process|dITP diphosphatase activity|identical protein binding|protein homodimerization activity|IDP catabolic process|m7G(5')pppN diphosphatase activity|cobalt ion binding|positive regulation of cell cycle process|dIDP diphosphatase activity|nucleotide phosphatase activity, acting on free nucleotides|XDP catabolic process|XTP binding|ITP binding|IDP phosphatase activity|negative regulation of rRNA processing|positive regulation of double-strand break repair hsa00230,hsa03018 Purine metabolism|RNA degradation NUDT16L1 528.250798513914 474.034988509986 582.466608517842 1.22874180732668 0.297181797384921 0.162768357245392 1 5.14651 5.70112 6.17643 6.68042 GeneID:84309,Genbank:XM_005255633.5,HGNC:HGNC:28154,MIM:617338 nudix hydrolase 16 like 1 GO:0003723,GO:0005634,GO:0016787,GO:0030515,GO:2001033 RNA binding|nucleus|hydrolase activity|snoRNA binding|negative regulation of double-strand break repair via nonhomologous end joining hsa05205 Proteoglycans in cancer NUDT17 60.2156758404015 58.8937951282906 61.5375565525124 1.04489032195094 0.0633515161992911 0.864534237229334 1 0.576495 0.506946 0.354929 0.719255 GeneID:200035,Genbank:XM_011509260.2,HGNC:HGNC:26618 nudix hydrolase 17 GO:0016787,GO:0046872 hydrolase activity|metal ion binding NUDT18 193.61048260895 176.912725104043 210.308240113856 1.1887683036377 0.249467554641292 0.290984673829502 1 3.14363 3.80891 3.90722 4.74274 GeneID:79873,Genbank:XM_011544650.1,HGNC:HGNC:26194,MIM:615791 nudix hydrolase 18 GO:0000287,GO:0005829,GO:0034656,GO:0044715,GO:0044716,GO:0044717,GO:0046057,GO:0046067,GO:0046712 magnesium ion binding|cytosol|nucleobase-containing small molecule catabolic process|8-oxo-dGDP phosphatase activity|8-oxo-GDP phosphatase activity|8-hydroxy-dADP phosphatase activity|dADP catabolic process|dGDP catabolic process|GDP catabolic process NUDT19 473.371488153035 534.811617006097 411.931359299974 0.770236371464753 -0.376626844392177 0.0334351726710141 0.722752120505173 7.80656 7.47802 6.01664 5.93751 GeneID:390916,Genbank:XM_017026806.2,HGNC:HGNC:32036 nudix hydrolase 19 GO:0005102,GO:0005739,GO:0005782,GO:0009062,GO:0046872,GO:0047617 receptor binding|mitochondrion|peroxisomal matrix|fatty acid catabolic process|metal ion binding|acyl-CoA hydrolase activity hsa04146 Peroxisome NUDT2 520.947789436007 523.867367029619 518.028211842394 0.988853752772703 -0.0161709265329712 0.920270354287334 1 15.6018 16.3185 14.8128 16.2718 GeneID:318,Genbank:NM_001161.4,HGNC:HGNC:8049,MIM:602852 nudix hydrolase 2 GO:0004081,GO:0005525,GO:0005759,GO:0006139,GO:0006915,GO:0008803,GO:0034599 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity|GTP binding|mitochondrial matrix|nucleobase-containing compound metabolic process|apoptotic process|bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity|cellular response to oxidative stress hsa00230,hsa00240 Purine metabolism|Pyrimidine metabolism NUDT21 1987.63457058933 2129.21166626436 1846.05747491431 0.867014540716453 -0.205871905772885 0.192250845852381 1 22.7164 20.3847 20.5959 17.0456 GeneID:11051,Genbank:NM_007006.2,HGNC:HGNC:13870,MIM:604978 nudix hydrolase 21 GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005813,GO:0005815,GO:0005849,GO:0006369,GO:0006378,GO:0006397,GO:0016604,GO:0016787,GO:0017091,GO:0031124,GO:0031442,GO:0042382,GO:0042802,GO:0042803,GO:0042826,GO:0051262 mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|centrosome|microtubule organizing center|mRNA cleavage factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA processing|nuclear body|hydrolase activity|AU-rich element binding|mRNA 3'-end processing|positive regulation of mRNA 3'-end processing|paraspeckles|identical protein binding|protein homodimerization activity|histone deacetylase binding|protein tetramerization hsa03015 mRNA surveillance pathway NUDT22 495.986681273537 437.597216976617 554.376145570456 1.2668639654536 0.341261617689449 0.0531383869943263 0.840972733301513 11.1538 10.9093 13.1225 14.1156 GeneID:84304,Genbank:NM_001128612.2,HGNC:HGNC:28189 nudix hydrolase 22 GO:0005654,GO:0016787 nucleoplasm|hydrolase activity NUDT3 127.346223321799 120.939741077281 133.752705566316 1.10594502993725 0.145279679417289 0.603409529255909 1 6.38663 6.63308 7.47587 7.15135 GeneID:11165,Genbank:NM_006703.3,HGNC:HGNC:8050,MIM:609228 nudix hydrolase 3 GO:0000287,GO:0000298,GO:0005634,GO:0005737,GO:0005829,GO:0007267,GO:0008486,GO:0015961,GO:0034431,GO:0034432,GO:0043647,GO:0050072,GO:0052840,GO:0052841,GO:0052842,GO:0052843,GO:0052844,GO:0052845,GO:0052846,GO:0052847,GO:0052848,GO:0070062,GO:0071544,GO:1901907,GO:1901909,GO:1901911 magnesium ion binding|endopolyphosphatase activity|nucleus|cytoplasm|cytosol|cell-cell signaling|diphosphoinositol-polyphosphate diphosphatase activity|diadenosine polyphosphate catabolic process|bis(5'-adenosyl)-hexaphosphatase activity|bis(5'-adenosyl)-pentaphosphatase activity|inositol phosphate metabolic process|m7G(5')pppN diphosphatase activity|inositol diphosphate tetrakisphosphate diphosphatase activity|inositol bisdiphosphate tetrakisphosphate diphosphatase activity|inositol diphosphate pentakisphosphate diphosphatase activity|inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity|inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity|inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity|inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity|extracellular exosome|diphosphoinositol polyphosphate catabolic process|diadenosine pentaphosphate catabolic process|diadenosine hexaphosphate catabolic process|adenosine 5'-(hexahydrogen pentaphosphate) catabolic process NUDT4 1391.77257047197 1253.95365672964 1529.59148421429 1.21981500353332 0.286662366048413 0.0485054114542692 0.806708656465773 8.16125 8.20697 11.0276 8.98453 GeneID:11163,Genbank:NM_199040.3,HGNC:HGNC:8051,MIM:609229 nudix hydrolase 4 GO:0005737,GO:0008486,GO:0030515,GO:0046872,GO:0052840,GO:0052843,GO:0052844,GO:0052845,GO:0052846,GO:0052847,GO:0052848 cytoplasm|diphosphoinositol-polyphosphate diphosphatase activity|snoRNA binding|metal ion binding|inositol diphosphate tetrakisphosphate diphosphatase activity|inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity|inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity|inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity|inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity NUDT4B 4.45472999708092 3.57457863775636 5.33488135640547 1.49245041081373 0.577682996306395 0.787607572381644 1 0.0554862 0.0530773 0.0667059 0.0124324 GeneID:440672,Genbank:NM_001355407.1,HGNC:HGNC:18012 nudix hydrolase 4B GO:0005737,GO:0008486,GO:0030515,GO:0046872,GO:0052840,GO:0052843,GO:0052844,GO:0052845,GO:0052846,GO:0052847,GO:0052848 cytoplasm|diphosphoinositol-polyphosphate diphosphatase activity|snoRNA binding|metal ion binding|inositol diphosphate tetrakisphosphate diphosphatase activity|inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity|inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity|inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity|inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity|inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity NUDT5 1478.08933271438 1541.6292763286 1414.54938910017 0.917567803634952 -0.124113325101966 0.403151327757866 1 13.0811 12.6531 11.3982 11.9663 GeneID:11164,Genbank:NM_001321647.1,HGNC:HGNC:8052,MIM:609230 nudix hydrolase 5 GO:0000287,GO:0005634,GO:0006338,GO:0009191,GO:0016779,GO:0019144,GO:0019303,GO:0030515,GO:0042803,GO:0044715,GO:0047631 magnesium ion binding|nucleus|chromatin remodeling|ribonucleoside diphosphate catabolic process|nucleotidyltransferase activity|ADP-sugar diphosphatase activity|D-ribose catabolic process|snoRNA binding|protein homodimerization activity|8-oxo-dGDP phosphatase activity|ADP-ribose diphosphatase activity hsa00230 Purine metabolism NUDT6 142.63061890434 149.564779143801 135.696458664879 0.907275492543679 -0.140387405900143 0.617111625493796 1 4.28467 3.38998 3.6044 3.47496 GeneID:11162,Genbank:NM_198041.2,HGNC:HGNC:8053,MIM:606261 nudix hydrolase 6 NUDT7 55.8586716604936 56.4630554287197 55.2542878922675 0.978591885839792 -0.0312207744168638 0.934206139453236 1 0.744201 1.37942 1.5749 0.989741 GeneID:283927,Genbank:XM_017023170.1,HGNC:HGNC:8054,MIM:609231 nudix hydrolase 7 GO:0000287,GO:0003986,GO:0005102,GO:0005777,GO:0005782,GO:0009062,GO:0009132,GO:0015938,GO:0016289,GO:0016818,GO:0030145,GO:0030515,GO:0046356,GO:0050873 magnesium ion binding|acetyl-CoA hydrolase activity|receptor binding|peroxisome|peroxisomal matrix|fatty acid catabolic process|nucleoside diphosphate metabolic process|coenzyme A catabolic process|CoA hydrolase activity|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|manganese ion binding|snoRNA binding|acetyl-CoA catabolic process|brown fat cell differentiation hsa04146 Peroxisome NUDT8 67.1700049028769 65.0344006354196 69.3056091703343 1.06567614205994 0.0917690710877143 0.846612351699075 1 2.10193 2.15297 2.50304 2.87344 GeneID:254552,Genbank:XM_017017474.2,HGNC:HGNC:8055 nudix hydrolase 8 GO:0016787,GO:0046872 hydrolase activity|metal ion binding NUDT9 408.989914538977 391.982358975006 425.997470102948 1.08677714787188 0.120056134825514 0.508330139793807 1 2.87958 2.82175 3.30891 2.95148 GeneID:53343,Genbank:XM_011532032.2,HGNC:HGNC:8056,MIM:606022 nudix hydrolase 9 GO:0005622,GO:0005739,GO:0005759,GO:0019144,GO:0034656,GO:0043262,GO:0046032,GO:0046709,GO:0047631,GO:0070062 intracellular|mitochondrion|mitochondrial matrix|ADP-sugar diphosphatase activity|nucleobase-containing small molecule catabolic process|adenosine-diphosphatase activity|ADP catabolic process|IDP catabolic process|ADP-ribose diphosphatase activity|extracellular exosome hsa00230 Purine metabolism NUF2 571.691993157441 607.349959149185 536.034027165697 0.882578518514445 -0.180203461566022 0.29797947166726 1 7.62807 7.37868 7.49942 6.09415 GeneID:83540,Genbank:NM_145697.2,HGNC:HGNC:14621,MIM:611772 NUF2, NDC80 kinetochore complex component GO:0000278,GO:0000775,GO:0000777,GO:0005634,GO:0005829,GO:0007059,GO:0007062,GO:0016020,GO:0031262,GO:0051301 mitotic cell cycle|chromosome, centromeric region|condensed chromosome kinetochore|nucleus|cytosol|chromosome segregation|sister chromatid cohesion|membrane|Ndc80 complex|cell division NUFIP1 195.010510191119 216.991701859215 173.029318523023 0.797400624265739 -0.326623360100485 0.160885397284105 1 2.21323 2.05754 1.9613 1.47772 GeneID:26747,Genbank:NM_012345.2,HGNC:HGNC:8057,MIM:604354 NUFIP1, FMR1 interacting protein 1 GO:0000492,GO:0001650,GO:0003677,GO:0003723,GO:0005634,GO:0005726,GO:0005730,GO:0006396,GO:0008023,GO:0016363,GO:0030674,GO:0042802,GO:0043234,GO:0045944,GO:0046872,GO:0048786,GO:0051117,GO:0051259,GO:0070761 box C/D snoRNP assembly|fibrillar center|DNA binding|RNA binding|nucleus|perichromatin fibrils|nucleolus|RNA processing|transcription elongation factor complex|nuclear matrix|protein binding, bridging|identical protein binding|protein complex|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|presynaptic active zone|ATPase binding|protein oligomerization|pre-snoRNP complex NUFIP2 1490.84742545426 1576.50753875927 1405.18731214925 0.891329269034231 -0.165969613701478 0.62639917886966 1 6.04235 5.0204 6.05341 3.85901 GeneID:57532,Genbank:NM_020772.2,HGNC:HGNC:17634,MIM:609356 NUFIP2, FMR1 interacting protein 2 GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0010494,GO:0016020,GO:0016604,GO:0042788 RNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoplasmic stress granule|membrane|nuclear body|polysomal ribosome NUMA1 4194.59035356723 3961.19353527003 4427.98717186443 1.11784166374052 0.160715852659107 0.231460671117363 1 15.4622 15.1925 17.6661 17.3562 GeneID:4926,Genbank:NM_006185.3,HGNC:HGNC:8059,MIM:164009 nuclear mitotic apparatus protein 1 NUMB 935.119047243915 921.797209412159 948.44088507567 1.0289040532901 0.0411084552188782 0.784888228471594 1 8.4323 8.11403 8.99153 8.0305 GeneID:8650,Genbank:NM_001005745.1,HGNC:HGNC:8060,MIM:603728 NUMB, endocytic adaptor protein hsa04330 Notch signaling pathway NUMBL 762.746479060481 772.397143403484 753.095814717477 0.975011134037916 -0.0365094012255539 0.793433448876295 1 7.4086 8.13399 7.63991 7.8862 GeneID:9253,Genbank:NM_001289979.1,HGNC:HGNC:8061,MIM:604018 NUMB like, endocytic adaptor protein GO:0005737,GO:0007399,GO:0007409,GO:0019221,GO:0019538,GO:0021670,GO:0021849,GO:0034332,GO:0050769 cytoplasm|nervous system development|axonogenesis|cytokine-mediated signaling pathway|protein metabolic process|lateral ventricle development|neuroblast division in subventricular zone|adherens junction organization|positive regulation of neurogenesis hsa04330 Notch signaling pathway NUP107 823.87754107955 870.839592263702 776.915489895399 0.892145346625604 -0.164649324457228 0.311384603405699 1 4.89953 4.46446 4.93998 3.96879 GeneID:57122,Genbank:NM_001330192.1,HGNC:HGNC:29914,MIM:607617 nucleoporin 107 GO:0000777,GO:0000973,GO:0005487,GO:0005635,GO:0005643,GO:0005829,GO:0006110,GO:0006355,GO:0006406,GO:0006409,GO:0006606,GO:0007062,GO:0007077,GO:0008585,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031080,GO:0031965,GO:0034399,GO:0043657,GO:0051292,GO:0060964,GO:0075733,GO:1900034 condensed chromosome kinetochore|posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|nucleocytoplasmic transporter activity|nuclear envelope|nuclear pore|cytosol|regulation of glycolytic process|regulation of transcription, DNA-templated|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|sister chromatid cohesion|mitotic nuclear envelope disassembly|female gonad development|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear pore outer ring|nuclear membrane|nuclear periphery|host cell|nuclear pore complex assembly|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP133 914.684368879043 973.465412025783 855.903325732302 0.879233422326907 -0.185681866347248 0.232081846092448 1 9.2153 9.48987 8.85544 7.2278 GeneID:55746,Genbank:NM_018230.2,HGNC:HGNC:18016,MIM:607613 nucleoporin 133 GO:0000777,GO:0000972,GO:0005487,GO:0005635,GO:0005643,GO:0005829,GO:0006110,GO:0006325,GO:0006355,GO:0006406,GO:0006409,GO:0006606,GO:0006999,GO:0007062,GO:0007077,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0021915,GO:0022008,GO:0031080,GO:0031081,GO:0031965,GO:0043657,GO:0048339,GO:0060964,GO:0061053,GO:0075733,GO:1900034 condensed chromosome kinetochore|transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|nucleocytoplasmic transporter activity|nuclear envelope|nuclear pore|cytosol|regulation of glycolytic process|chromatin organization|regulation of transcription, DNA-templated|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear pore organization|sister chromatid cohesion|mitotic nuclear envelope disassembly|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|neural tube development|neurogenesis|nuclear pore outer ring|nuclear pore distribution|nuclear membrane|host cell|paraxial mesoderm development|regulation of gene silencing by miRNA|somite development|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP153 1866.58353082534 2000.81702695495 1732.35003469573 0.865821317670512 -0.207858772832227 0.405573558644641 1 12.2609 11.6241 12.5861 8.17875 GeneID:9972,Genbank:NM_001278210.1,HGNC:HGNC:8062,MIM:603948 nucleoporin 153 GO:0003677,GO:0005487,GO:0005643,GO:0005654,GO:0005730,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0007077,GO:0008139,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0034399,GO:0042405,GO:0042802,GO:0043495,GO:0043657,GO:0044615,GO:0046718,GO:0046832,GO:0046872,GO:0051292,GO:0060964,GO:0075732,GO:0075733,GO:1900034 DNA binding|nucleocytoplasmic transporter activity|nuclear pore|nucleoplasm|nucleolus|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|mitotic nuclear envelope disassembly|nuclear localization sequence binding|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|nuclear periphery|nuclear inclusion body|identical protein binding|protein membrane anchor|host cell|nuclear pore nuclear basket|viral entry into host cell|negative regulation of RNA export from nucleus|metal ion binding|nuclear pore complex assembly|regulation of gene silencing by miRNA|viral penetration into host nucleus|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP155 941.283434089941 1005.30922749705 877.257640682832 0.872624677749123 -0.196566821307195 0.208901029079785 1 6.98092 6.81701 6.51981 5.17119 GeneID:9631,Genbank:NM_001278312.1,HGNC:HGNC:8063,MIM:606694 nucleoporin 155 GO:0000972,GO:0005215,GO:0005635,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0006998,GO:0007077,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0036228,GO:0043657,GO:0044611,GO:0060964,GO:0075733,GO:0086014,GO:1900034 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|transporter activity|nuclear envelope|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|nuclear envelope organization|mitotic nuclear envelope disassembly|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|protein localization to nuclear inner membrane|host cell|nuclear pore inner ring|regulation of gene silencing by miRNA|intracellular transport of virus|atrial cardiac muscle cell action potential|regulation of cellular response to heat hsa03013 RNA transport NUP160 1290.78501218867 1368.87827081449 1212.69175356284 0.885901821526676 -0.174781271327029 0.324112903467393 1 7.5209 7.67261 8.09061 5.62311 GeneID:23279,Genbank:NM_015231.2,HGNC:HGNC:18017,MIM:607614 nucleoporin 160 GO:0005487,GO:0005635,GO:0005643,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0007062,GO:0007077,GO:0016032,GO:0016925,GO:0019083,GO:0031080,GO:0043657,GO:0060964,GO:0075733,GO:1900034 nucleocytoplasmic transporter activity|nuclear envelope|nuclear pore|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|sister chromatid cohesion|mitotic nuclear envelope disassembly|viral process|protein sumoylation|viral transcription|nuclear pore outer ring|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP188 3237.56863999863 3350.62581571696 3124.5114642803 0.932515785446405 -0.100799947650862 0.445637488536936 1 21.7578 23.4097 22.8193 20.1615 GeneID:23511,Genbank:NM_015354.2,HGNC:HGNC:17859,MIM:615587 nucleoporin 188 GO:0005635,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0007077,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0043657,GO:0044611,GO:0060964,GO:0075733,GO:0090521,GO:1900034 nuclear envelope|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|mitotic nuclear envelope disassembly|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|host cell|nuclear pore inner ring|regulation of gene silencing by miRNA|intracellular transport of virus|glomerular visceral epithelial cell migration|regulation of cellular response to heat hsa03013 RNA transport NUP205 3619.79872242711 3817.30363119245 3422.29381366178 0.896521247536372 -0.157590319543734 0.304643198442272 1 24.0408 22.5587 23.9509 18.2964 GeneID:23165,Genbank:NM_001329434.1,HGNC:HGNC:18658,MIM:614352 nucleoporin 205 GO:0005635,GO:0005643,GO:0006110,GO:0006406,GO:0006409,GO:0006913,GO:0007077,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0034399,GO:0043657,GO:0044611,GO:0051292,GO:0060964,GO:0075733,GO:1900034 nuclear envelope|nuclear pore|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nucleocytoplasmic transport|mitotic nuclear envelope disassembly|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|nuclear periphery|host cell|nuclear pore inner ring|nuclear pore complex assembly|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP210 5400.09661841604 5645.22390116097 5154.96933567112 0.913155868735511 -0.131066956628826 0.313204326943977 1 18.6068 19.1135 17.9999 17.4272 GeneID:23225,Genbank:NM_024923.3,HGNC:HGNC:30052,MIM:607703 nucleoporin 210 GO:0005635,GO:0005643,GO:0005789,GO:0006110,GO:0006406,GO:0006409,GO:0007077,GO:0016020,GO:0016021,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0046983,GO:0060964,GO:0075733,GO:1900034 nuclear envelope|nuclear pore|endoplasmic reticulum membrane|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|mitotic nuclear envelope disassembly|membrane|integral component of membrane|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|protein dimerization activity|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP210L 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.018234 0 GeneID:91181,Genbank:XM_017002788.2,HGNC:HGNC:29915 nucleoporin 210 like GO:0007286,GO:0016021,GO:0060009 spermatid development|integral component of membrane|Sertoli cell development hsa03013 RNA transport NUP214 1324.7173438336 1372.39501452245 1277.03967314474 0.930519026687884 -0.1038924449494 0.486004220897896 1 6.47459 6.11598 6.25075 5.65213 GeneID:8021,Genbank:NM_005085.3,HGNC:HGNC:8064,MIM:114350 nucleoporin 214 hsa03013 RNA transport NUP35 208.571519313298 211.648942712369 205.494095914227 0.970919548572914 -0.0425763375368903 0.880389155556511 1 2.65431 2.32625 2.69968 2.21825 GeneID:129401,Genbank:XM_011510576.3,HGNC:HGNC:29797,MIM:608140 nucleoporin 35 GO:0003697,GO:0005487,GO:0005543,GO:0005635,GO:0005652,GO:0005654,GO:0005886,GO:0006110,GO:0006355,GO:0006406,GO:0006409,GO:0006607,GO:0006999,GO:0007077,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0044613,GO:0044615,GO:0060964,GO:0075733,GO:1900034 single-stranded DNA binding|nucleocytoplasmic transporter activity|phospholipid binding|nuclear envelope|nuclear lamina|nucleoplasm|plasma membrane|regulation of glycolytic process|regulation of transcription, DNA-templated|mRNA export from nucleus|tRNA export from nucleus|NLS-bearing protein import into nucleus|nuclear pore organization|mitotic nuclear envelope disassembly|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|nuclear pore central transport channel|nuclear pore nuclear basket|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP37 571.044245520384 568.799031529679 573.289459511089 1.00789457740343 0.0113447453743459 0.95286454145944 1 16.549 18.0011 17.4672 18.1542 GeneID:79023,Genbank:NM_024057.3,HGNC:HGNC:29929,MIM:609264 nucleoporin 37 GO:0000777,GO:0005634,GO:0005635,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0007062,GO:0007077,GO:0016032,GO:0016925,GO:0019083,GO:0031080,GO:0043657,GO:0051301,GO:0060964,GO:0075733,GO:1900034 condensed chromosome kinetochore|nucleus|nuclear envelope|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|sister chromatid cohesion|mitotic nuclear envelope disassembly|viral process|protein sumoylation|viral transcription|nuclear pore outer ring|host cell|cell division|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP43 1645.78280213337 1797.40324552649 1494.16235874026 0.831289451857306 -0.266577189433372 0.0653035151129576 0.901277047586747 10.327 10.0673 8.93887 7.82386 GeneID:348995,Genbank:NM_198887.2,HGNC:HGNC:21182,MIM:608141 nucleoporin 43 GO:0000777,GO:0005635,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0007062,GO:0007077,GO:0016032,GO:0016925,GO:0019083,GO:0031080,GO:0043657,GO:0051301,GO:0060964,GO:0075733,GO:1900034 condensed chromosome kinetochore|nuclear envelope|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|sister chromatid cohesion|mitotic nuclear envelope disassembly|viral process|protein sumoylation|viral transcription|nuclear pore outer ring|host cell|cell division|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP50 1165.0095736855 1302.50690914129 1027.5122382297 0.78887277373992 -0.342135448000586 0.0575600261736117 0.870520660242271 9.10325 7.95017 7.37502 5.76851 GeneID:10762,Genbank:NM_007172.3,HGNC:HGNC:8065,MIM:604646 nucleoporin 50 GO:0005643,GO:0005654,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0007077,GO:0008536,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043231,GO:0043657,GO:0060964,GO:0075733,GO:1900034 nuclear pore|nucleoplasm|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|mitotic nuclear envelope disassembly|Ran GTPase binding|viral process|protein sumoylation|viral transcription|nuclear membrane|intracellular membrane-bounded organelle|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP54 706.388224539322 796.811418604526 615.965030474119 0.773037403947941 -0.371389873253828 0.0238070865433803 0.61999072858338 6.12396 5.44065 4.61912 4.5334 GeneID:53371,Genbank:NM_001278603.1,HGNC:HGNC:17359,MIM:607607 nucleoporin 54 GO:0005487,GO:0005635,GO:0006110,GO:0006406,GO:0006409,GO:0006605,GO:0006607,GO:0006999,GO:0007077,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0036228,GO:0042306,GO:0043657,GO:0044613,GO:0051260,GO:0051290,GO:0060964,GO:0070208,GO:0075733,GO:1900034 nucleocytoplasmic transporter activity|nuclear envelope|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein targeting|NLS-bearing protein import into nucleus|nuclear pore organization|mitotic nuclear envelope disassembly|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|protein localization to nuclear inner membrane|regulation of protein import into nucleus|host cell|nuclear pore central transport channel|protein homooligomerization|protein heterotetramerization|regulation of gene silencing by miRNA|protein heterotrimerization|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP58 1406.30378366925 1520.00829971268 1292.59926762582 0.850389611602883 -0.233804121937143 0.11508346180231 1 13.0609 12.0571 11.8675 9.71915 GeneID:9818,Genbank:XM_011535329.3,HGNC:HGNC:20261,MIM:607615 nucleoporin 58 GO:0005487,GO:0005635,GO:0005643,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0007077,GO:0008139,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0042306,GO:0043657,GO:0051260,GO:0051290,GO:0060964,GO:0070208,GO:0075733,GO:1900034 nucleocytoplasmic transporter activity|nuclear envelope|nuclear pore|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|mitotic nuclear envelope disassembly|nuclear localization sequence binding|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|regulation of protein import into nucleus|host cell|protein homooligomerization|protein heterotetramerization|regulation of gene silencing by miRNA|protein heterotrimerization|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP62 3704.08480056897 3672.6368764191 3735.53272471883 1.0171255287185 0.0244977406349264 0.881189253268042 1 41.1059 44.4205 45.339 42.6165 GeneID:23636,Genbank:NM_016553.4,HGNC:HGNC:8066,MIM:605815 nucleoporin 62 GO:0000922,GO:0003682,GO:0005487,GO:0005543,GO:0005634,GO:0005635,GO:0005642,GO:0005643,GO:0005737,GO:0005813,GO:0006110,GO:0006351,GO:0006406,GO:0006409,GO:0006606,GO:0007077,GO:0007080,GO:0007098,GO:0007100,GO:0007166,GO:0007283,GO:0007569,GO:0008219,GO:0008285,GO:0009755,GO:0009966,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0019894,GO:0030159,GO:0030529,GO:0030544,GO:0031965,GO:0042059,GO:0042169,GO:0042306,GO:0043066,GO:0043069,GO:0043123,GO:0043130,GO:0043407,GO:0043657,GO:0044613,GO:0045742,GO:0045840,GO:0045893,GO:0046578,GO:0046580,GO:0046601,GO:0046966,GO:0051425,GO:0051879,GO:0060236,GO:0060964,GO:0070208,GO:0071426,GO:0072686,GO:0075733,GO:0090543,GO:0098534,GO:1900034,GO:1903438,GO:1904781 spindle pole|chromatin binding|nucleocytoplasmic transporter activity|phospholipid binding|nucleus|nuclear envelope|annulate lamellae|nuclear pore|cytoplasm|centrosome|regulation of glycolytic process|transcription, DNA-templated|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|mitotic nuclear envelope disassembly|mitotic metaphase plate congression|centrosome cycle|mitotic centrosome separation|cell surface receptor signaling pathway|spermatogenesis|cell aging|cell death|negative regulation of cell proliferation|hormone-mediated signaling pathway|regulation of signal transduction|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|kinesin binding|receptor signaling complex scaffold activity|intracellular ribonucleoprotein complex|Hsp70 protein binding|nuclear membrane|negative regulation of epidermal growth factor receptor signaling pathway|SH2 domain binding|regulation of protein import into nucleus|negative regulation of apoptotic process|negative regulation of programmed cell death|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|negative regulation of MAP kinase activity|host cell|nuclear pore central transport channel|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|regulation of Ras protein signal transduction|negative regulation of Ras protein signal transduction|positive regulation of centriole replication|thyroid hormone receptor binding|PTB domain binding|Hsp90 protein binding|regulation of mitotic spindle organization|regulation of gene silencing by miRNA|protein heterotrimerization|ribonucleoprotein complex export from nucleus|mitotic spindle|intracellular transport of virus|Flemming body|centriole assembly|regulation of cellular response to heat|positive regulation of mitotic cytokinetic process|positive regulation of protein localization to centrosome hsa03013 RNA transport NUP62CL 21.4437013510248 23.5038099837375 19.3835927183121 0.82470002657968 -0.278058640817981 0.669684439704539 1 0.431175 0.563703 0.285123 0.434751 GeneID:54830,Genbank:NM_017681.2,HGNC:HGNC:25960 nucleoporin 62 C-terminal like GO:0005487,GO:0005543,GO:0006606,GO:0017056,GO:0044613,GO:0071426 nucleocytoplasmic transporter activity|phospholipid binding|protein import into nucleus|structural constituent of nuclear pore|nuclear pore central transport channel|ribonucleoprotein complex export from nucleus NUP85 2018.73752417142 2099.02442944602 1938.45061889681 0.92350074239413 -0.114814973909319 0.407113642219693 1 19.2934 20.7982 17.9659 18.6523 GeneID:79902,Genbank:NM_001330472.1,HGNC:HGNC:8734,MIM:170285 nucleoporin 85 GO:0000777,GO:0005634,GO:0005635,GO:0005819,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0007062,GO:0007077,GO:0016020,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0030032,GO:0031080,GO:0031965,GO:0043657,GO:0045893,GO:0048246,GO:0060964,GO:0075733,GO:1900034 condensed chromosome kinetochore|nucleus|nuclear envelope|spindle|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|sister chromatid cohesion|mitotic nuclear envelope disassembly|membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|lamellipodium assembly|nuclear pore outer ring|nuclear membrane|host cell|positive regulation of transcription, DNA-templated|macrophage chemotaxis|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP88 1446.8141916845 1563.711915382 1329.91646798701 0.850486879907237 -0.233639114658625 0.108076609431826 1 10.6565 11.0837 10.1106 8.23745 GeneID:4927,Genbank:NM_002532.5,HGNC:HGNC:8067,MIM:602552 nucleoporin 88 GO:0000055,GO:0000056,GO:0005215,GO:0005643,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006606,GO:0007077,GO:0016032,GO:0016925,GO:0019083,GO:0043657,GO:0060964,GO:0075733,GO:1900034 ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|transporter activity|nuclear pore|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|mitotic nuclear envelope disassembly|viral process|protein sumoylation|viral transcription|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUP93 3415.25761170243 3397.95879395126 3432.5564294536 1.0101818878922 0.0146150802391583 0.92251889729812 1 31.2397 32.0417 31.9796 32.6908 GeneID:9688,Genbank:NM_014669.4,HGNC:HGNC:28958,MIM:614351 nucleoporin 93 GO:0005635,GO:0005643,GO:0006110,GO:0006406,GO:0006409,GO:0006998,GO:0007077,GO:0016020,GO:0016032,GO:0016925,GO:0016973,GO:0017056,GO:0019083,GO:0031965,GO:0034399,GO:0043657,GO:0051292,GO:0060391,GO:0060395,GO:0060964,GO:0072001,GO:0072015,GO:0075733,GO:0090521,GO:1900034,GO:1903206 nuclear envelope|nuclear pore|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nuclear envelope organization|mitotic nuclear envelope disassembly|membrane|viral process|protein sumoylation|poly(A)+ mRNA export from nucleus|structural constituent of nuclear pore|viral transcription|nuclear membrane|nuclear periphery|host cell|nuclear pore complex assembly|positive regulation of SMAD protein import into nucleus|SMAD protein signal transduction|regulation of gene silencing by miRNA|renal system development|glomerular visceral epithelial cell development|intracellular transport of virus|glomerular visceral epithelial cell migration|regulation of cellular response to heat|negative regulation of hydrogen peroxide-induced cell death hsa03013 RNA transport NUP98 3037.56251067826 3096.0122517649 2979.11276959162 0.962241918743494 -0.0555284450763898 0.682262297905824 1 12.983 13.1587 13.2734 11.7698 GeneID:4928,Genbank:NM_139132.3,HGNC:HGNC:8068,MIM:601021 nucleoporin 98 hsa03013,hsa05164 RNA transport|Influenza A NUPL2 714.330241295042 769.041044827227 659.619437762857 0.857716817846891 -0.221426686000348 0.18331571262519 1 11.013 8.98208 8.83857 7.71594 GeneID:11097,Genbank:XM_005249593.4,HGNC:HGNC:17010 nucleoporin like 2 GO:0003723,GO:0005049,GO:0005634,GO:0005643,GO:0005654,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006611,GO:0007077,GO:0016032,GO:0016925,GO:0019083,GO:0031965,GO:0043657,GO:0046872,GO:0060964,GO:0075733,GO:1900034 RNA binding|nuclear export signal receptor activity|nucleus|nuclear pore|nucleoplasm|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|protein export from nucleus|mitotic nuclear envelope disassembly|viral process|protein sumoylation|viral transcription|nuclear membrane|host cell|metal ion binding|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport NUPR1 1199.49533670289 1115.94090282557 1283.04977058022 1.14974705858663 0.201316506856438 0.593620956408523 1 21.9936 25.1379 22.9295 32.0389 GeneID:26471,Genbank:NM_012385.2,HGNC:HGNC:29990,MIM:614812 nuclear protein 1, transcriptional regulator GO:0002526,GO:0003677,GO:0003682,GO:0005634,GO:0005829,GO:0006351,GO:0006357,GO:0006461,GO:0006473,GO:0008283,GO:0008584,GO:0009636,GO:0031401,GO:0032993,GO:0035914,GO:0042771,GO:0043065,GO:0045786,GO:0048147,GO:2000194 acute inflammatory response|DNA binding|chromatin binding|nucleus|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein acetylation|cell proliferation|male gonad development|response to toxic substance|positive regulation of protein modification process|protein-DNA complex|skeletal muscle cell differentiation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of apoptotic process|negative regulation of cell cycle|negative regulation of fibroblast proliferation|regulation of female gonad development hsa05202 Transcriptional misregulation in cancer NUS1 1412.83976496731 1469.10953449487 1356.56999543975 0.923396086940644 -0.114978476170529 0.44317708275509 1 15.1415 15.0403 15.5325 12.4611 GeneID:116150,Genbank:NM_138459.4,HGNC:HGNC:21042,MIM:610463 NUS1 dehydrodolichyl diphosphate synthase subunit GO:0001525,GO:0004659,GO:0005789,GO:0006489,GO:0016021,GO:0019408,GO:0030154,GO:0032383,GO:0035268,GO:0042632 angiogenesis|prenyltransferase activity|endoplasmic reticulum membrane|dolichyl diphosphate biosynthetic process|integral component of membrane|dolichol biosynthetic process|cell differentiation|regulation of intracellular cholesterol transport|protein mannosylation|cholesterol homeostasis hsa00900 Terpenoid backbone biosynthesis NUSAP1 4434.28657222379 4411.43924579729 4457.13389865028 1.01035821878234 0.0148668858831711 0.883600383640434 1 44.9314 40.8561 44.0005 42.6143 GeneID:51203,Genbank:NM_016359.4,HGNC:HGNC:18538,MIM:612818 nucleolar and spindle associated protein 1 GO:0000070,GO:0000281,GO:0003677,GO:0003723,GO:0005694,GO:0005730,GO:0005737,GO:0005876,GO:0007076,GO:0008017,GO:0040001,GO:0045840 mitotic sister chromatid segregation|mitotic cytokinesis|DNA binding|RNA binding|chromosome|nucleolus|cytoplasm|spindle microtubule|mitotic chromosome condensation|microtubule binding|establishment of mitotic spindle localization|positive regulation of mitotic nuclear division NUTF2 2777.8539772583 2863.76170986096 2691.94624465564 0.940003574803834 -0.08926185156309 0.510529254466862 1 40.7709 39.4548 37.3317 39.6639 GeneID:10204,Genbank:NM_001322039.1,HGNC:HGNC:13722,MIM:605813 nuclear transport factor 2 GO:0000060,GO:0005487,GO:0005637,GO:0005640,GO:0005654,GO:0005829,GO:0006606,GO:0006611,GO:0008536,GO:0008565,GO:0031965,GO:0042307,GO:0042802,GO:0044613,GO:0051028,GO:0070062,GO:0090204,GO:1904046 protein import into nucleus, translocation|nucleocytoplasmic transporter activity|nuclear inner membrane|nuclear outer membrane|nucleoplasm|cytosol|protein import into nucleus|protein export from nucleus|Ran GTPase binding|protein transporter activity|nuclear membrane|positive regulation of protein import into nucleus|identical protein binding|nuclear pore central transport channel|mRNA transport|extracellular exosome|protein localization to nuclear pore|negative regulation of vascular endothelial growth factor production NUTM2A 1.59027989258444 3.18055978516888 0 0 -Inf 0.214127562460916 1 0 0.0110434 0 0.00538923 GeneID:728118,Genbank:XM_017016607.1,HGNC:HGNC:23438 NUT family member 2A NUTM2B 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.0106339 0.0112296 0.0105498 GeneID:729262,Genbank:NM_001278495.1,HGNC:HGNC:23445 NUT family member 2B NUTM2D 13.4636251771363 11.9057924710315 15.0214578832411 1.26169324047857 0.335361185885818 0.813890068815451 1 0.00753011 0.106792 0.077358 0.105504 GeneID:728130,Genbank:NM_001009610.1,HGNC:HGNC:23447 NUT family member 2D NUTM2E 17.7913185962925 14.7403596782979 20.8422775142872 1.4139599011938 0.499741207014968 0.490226636395031 1 0.0325226 0.0233063 0.0609196 0.0171267 GeneID:283008,Genbank:XM_024447950.1,HGNC:HGNC:23448 NUT family member 2E NUTM2F 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0134752 0 0.0134993 GeneID:54754,Genbank:NM_017561.1,HGNC:HGNC:23450 NUT family member 2F NUTM2G 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0.00679658 0 0 GeneID:441457,Genbank:NM_001045477.2,HGNC:HGNC:23449 NUT family member 2G NVL 524.53065862066 540.702282484694 508.359034756626 0.940182890333956 -0.0889866686153965 0.604465851643235 1 2.86057 3.07292 2.84793 2.93516 GeneID:4931,Genbank:NM_001243146.1,HGNC:HGNC:8070,MIM:602426 nuclear VCP-like GO:0003723,GO:0005524,GO:0005634,GO:0005654,GO:0005697,GO:0005730,GO:0016020,GO:0042254,GO:0051973,GO:1990275 RNA binding|ATP binding|nucleus|nucleoplasm|telomerase holoenzyme complex|nucleolus|membrane|ribosome biogenesis|positive regulation of telomerase activity|preribosome binding hsa03008 Ribosome biogenesis in eukaryotes NWD1 42.904817194642 26.6843697689064 59.1252646203775 2.21572647705071 1.14777979720025 0.00909057475120425 0.373319603116121 0.0654793 0.0848421 0.229436 0.189215 GeneID:284434,Genbank:XM_017026669.1,HGNC:HGNC:27619,MIM:616250 NACHT and WD repeat domain containing 1 GO:0003723,GO:0005524,GO:0005682,GO:0005829,GO:0008380,GO:0071011,GO:0071013 RNA binding|ATP binding|U5 snRNP|cytosol|RNA splicing|precatalytic spliceosome|catalytic step 2 spliceosome NWD2 1.26483015846966 1.07619535328461 1.45346496365472 1.35055866875717 0.43355631240266 1 1 0 0 0 0.00898388 GeneID:57495,Genbank:NM_001144990.1,HGNC:HGNC:29229 NACHT and WD repeat domain containing 2 NXF1 1366.59416154796 1418.3950997224 1314.79322337352 0.926958379672097 -0.109423531428857 0.444780469373818 1 10.902 10.9277 10.1247 10.0688 GeneID:10482,Genbank:NM_006362.4,HGNC:HGNC:8071,MIM:602647 nuclear RNA export factor 1 GO:0003723,GO:0003729,GO:0005643,GO:0005654,GO:0005829,GO:0006405,GO:0006406,GO:0016032,GO:0016607,GO:0016973,GO:0042405 RNA binding|mRNA binding|nuclear pore|nucleoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|viral process|nuclear speck|poly(A)+ mRNA export from nucleus|nuclear inclusion body hsa03008,hsa03013,hsa03015,hsa05164,hsa05168 Ribosome biogenesis in eukaryotes|RNA transport|mRNA surveillance pathway|Influenza A|Herpes simplex infection NXF3 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0395972 0 0 0 GeneID:56000,Genbank:NM_022052.1,HGNC:HGNC:8073,MIM:300316 nuclear RNA export factor 3 GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005737,GO:0006406,GO:0016973,GO:0042272 RNA binding|mRNA binding|nucleus|nucleoplasm|cytoplasm|mRNA export from nucleus|poly(A)+ mRNA export from nucleus|nuclear RNA export factor complex hsa03008,hsa03013,hsa03015,hsa05164,hsa05168 Ribosome biogenesis in eukaryotes|RNA transport|mRNA surveillance pathway|Influenza A|Herpes simplex infection NXN 1127.47499336839 1204.73784512752 1050.21214160926 0.871734996835018 -0.198038465455762 0.178089272581597 1 8.14132 8.54295 7.78895 7.08024 GeneID:64359,Genbank:NM_022463.4,HGNC:HGNC:18008,MIM:612895 nucleoredoxin GO:0004791,GO:0005634,GO:0005737,GO:0005829,GO:0016055,GO:0030154,GO:0030178,GO:0031397,GO:0045454,GO:0047134,GO:0072358 thioredoxin-disulfide reductase activity|nucleus|cytoplasm|cytosol|Wnt signaling pathway|cell differentiation|negative regulation of Wnt signaling pathway|negative regulation of protein ubiquitination|cell redox homeostasis|protein-disulfide reductase activity|cardiovascular system development NXNL2 1.99536914806221 1.56626675524197 2.42447154088245 1.54793015478893 0.630340376125113 0.890462484667886 1 0.0370775 0.0172934 0.0354094 0.0164126 GeneID:158046,Genbank:XM_011518276.2,HGNC:HGNC:30482,MIM:615299 nucleoredoxin like 2 GO:0004791,GO:0005737,GO:0007601,GO:0007608,GO:0045494 thioredoxin-disulfide reductase activity|cytoplasm|visual perception|sensory perception of smell|photoreceptor cell maintenance NXPE3 1709.4962971039 1714.37149018845 1704.62110401935 0.994312559311153 -0.00822866474282997 0.972367916746129 1 8.0223 7.72877 9.0248 6.7799 GeneID:91775,Genbank:NM_001348992.1,HGNC:HGNC:28238 neurexophilin and PC-esterase domain family member 3 GO:0005576 extracellular region NXPH2 36.828895610645 37.792315879655 35.8654753416351 0.949015018181058 -0.0754971767833414 0.925360147847796 1 0.643805 0.484359 0.608742 0.478602 GeneID:11249,Genbank:NM_007226.2,HGNC:HGNC:8076,MIM:604635 neurexophilin 2 GO:0005102,GO:0005576,GO:0007218 receptor binding|extracellular region|neuropeptide signaling pathway NXPH3 3.94053709130599 3.03648096111406 4.84459322149792 1.59546306515305 0.673975210724838 0.738230235518224 1 0.0156917 0.0275523 0.0219394 0.0479384 GeneID:11248,Genbank:NM_007225.2,HGNC:HGNC:8077,MIM:604636 neurexophilin 3 GO:0005102,GO:0005576,GO:0007218 receptor binding|extracellular region|neuropeptide signaling pathway NXPH4 137.41433345365 122.659895311686 152.168771595614 1.2405747714764 0.311008691447448 0.245617830328737 1 4.24077 4.50803 5.54064 5.65666 GeneID:11247,Genbank:NM_007224.3,HGNC:HGNC:8078,MIM:604637 neurexophilin 4 GO:0005102,GO:0005576,GO:0007218 receptor binding|extracellular region|neuropeptide signaling pathway NXT1 443.359535095995 459.73667395896 426.98239623303 0.928754263948814 -0.106631165748982 0.5389685347923 1 13.2847 15.9031 14.8494 13.3394 GeneID:29107,Genbank:NM_013248.2,HGNC:HGNC:15913,MIM:605811 nuclear transport factor 2 like export factor 1 GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0006405,GO:0006406,GO:0006611,GO:0008536,GO:0016607 nuclear pore|nucleoplasm|cytoplasm|cytosol|RNA export from nucleus|mRNA export from nucleus|protein export from nucleus|Ran GTPase binding|nuclear speck hsa03008,hsa03013,hsa03015,hsa05164 Ribosome biogenesis in eukaryotes|RNA transport|mRNA surveillance pathway|Influenza A NXT2 242.59514673744 269.994831508909 215.195461965971 0.797035486802902 -0.3272841354209 0.209871720730869 1 4.09228 3.3342 3.22155 2.53258 GeneID:55916,Genbank:NM_018698.4,HGNC:HGNC:18151,MIM:300320 nuclear transport factor 2 like export factor 2 GO:0005654,GO:0005829,GO:0015031,GO:0048471,GO:0051028 nucleoplasm|cytosol|protein transport|perinuclear region of cytoplasm|mRNA transport hsa03008,hsa03013,hsa03015,hsa05164 Ribosome biogenesis in eukaryotes|RNA transport|mRNA surveillance pathway|Influenza A NYAP1 59.4134561538457 60.6717842924883 58.1551280152032 0.958520153863405 -0.0611193285410283 0.87362534011326 1 0.505661 0.633082 0.56905 0.512998 GeneID:222950,Genbank:NM_173564.3,HGNC:HGNC:22009,MIM:615477 neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1 GO:0005622,GO:0014065,GO:0048812 intracellular|phosphatidylinositol 3-kinase signaling|neuron projection morphogenesis NYAP2 4.99402426532822 5.14084539299833 4.84720313765811 0.942880551175464 -0.0848530802351753 1 1 0.0152406 0.0145421 0.0175711 0.0109182 GeneID:57624,Genbank:XM_011511524.1,HGNC:HGNC:29291,MIM:615478 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 GO:0005622,GO:0014065,GO:0048812 intracellular|phosphatidylinositol 3-kinase signaling|neuron projection morphogenesis NYNRIN 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00436615 0 0 GeneID:57523,Genbank:NM_025081.2,HGNC:HGNC:20165 NYN domain and retroviral integrase containing GO:0003676,GO:0015074,GO:0016021 nucleic acid binding|DNA integration|integral component of membrane OAF 367.217023240093 381.634041604963 352.800004875222 0.924445847103998 -0.113339284076423 0.538034746138819 1 6.67123 7.06712 6.27597 6.48604 GeneID:220323,Genbank:NM_178507.3,HGNC:HGNC:28752 out at first homolog GO:0070062 extracellular exosome OARD1 423.936664832208 409.739582304202 438.133747360215 1.06929807683294 0.0966640738489755 0.579625421549159 1 6.40708 5.55999 7.07946 6.02832 GeneID:221443,Genbank:NM_001329690.1,HGNC:HGNC:21257,MIM:614393 O-acyl-ADP-ribose deacylase 1 GO:0001883,GO:0019213,GO:0042278 purine nucleoside binding|deacetylase activity|purine nucleoside metabolic process OAS1 889.242514510931 367.172030919667 1411.31299810219 3.84373775575236 1.94250990963362 0.36289331816521 1 3.31761 3.4147 23.7017 2.23898 GeneID:4938,Genbank:NM_001320151.1,HGNC:HGNC:8086,MIM:164350 2'-5'-oligoadenylate synthetase 1 GO:0001730,GO:0003725,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0006006,GO:0006164,GO:0008270,GO:0009615,GO:0035457,GO:0042593,GO:0045071,GO:0046872,GO:0051259,GO:0051607,GO:0060333,GO:0060337,GO:0060700 2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|ATP binding|extracellular region|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|glucose metabolic process|purine nucleotide biosynthetic process|zinc ion binding|response to virus|cellular response to interferon-alpha|glucose homeostasis|negative regulation of viral genome replication|metal ion binding|protein oligomerization|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|regulation of ribonuclease activity hsa04621,hsa05160,hsa05162,hsa05164,hsa05168,hsa05169 NOD-like receptor signaling pathway|Hepatitis C|Measles|Influenza A|Herpes simplex infection|Epstein-Barr virus infection OAS2 725.827877585643 261.914574705021 1189.74118046627 4.54247795032484 2.18347951147993 0.372853476175981 1 1.32636 1.53451 12.9068 0.807086 GeneID:4939,Genbank:NM_016817.2,HGNC:HGNC:8087,MIM:603350 2'-5'-oligoadenylate synthetase 2 GO:0001730,GO:0003725,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0006139,GO:0006164,GO:0006401,GO:0006486,GO:0008270,GO:0009615,GO:0016020,GO:0018377,GO:0043231,GO:0046872,GO:0048471,GO:0051607,GO:0060333,GO:0060337 2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|nucleobase-containing compound metabolic process|purine nucleotide biosynthetic process|RNA catabolic process|protein glycosylation|zinc ion binding|response to virus|membrane|protein myristoylation|intracellular membrane-bounded organelle|metal ion binding|perinuclear region of cytoplasm|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway hsa04621,hsa05160,hsa05162,hsa05164,hsa05168,hsa05169 NOD-like receptor signaling pathway|Hepatitis C|Measles|Influenza A|Herpes simplex infection|Epstein-Barr virus infection OAS3 2573.65881914308 1617.51289139198 3529.80474689418 2.18224211113183 1.12581117185043 0.435968665293934 1 8.98738 8.67631 34.3781 5.95722 GeneID:4940,Genbank:NM_006187.3,HGNC:HGNC:8088,MIM:603351 2'-5'-oligoadenylate synthetase 3 GO:0001730,GO:0003725,GO:0005524,GO:0005615,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0009615,GO:0043231,GO:0045071,GO:0046872,GO:0051607,GO:0060333,GO:0060337,GO:0060700 2'-5'-oligoadenylate synthetase activity|double-stranded RNA binding|ATP binding|extracellular space|nucleoplasm|cytoplasm|cytosol|plasma membrane|nucleobase-containing compound metabolic process|response to virus|intracellular membrane-bounded organelle|negative regulation of viral genome replication|metal ion binding|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|regulation of ribonuclease activity hsa04621,hsa05160,hsa05162,hsa05164,hsa05168,hsa05169 NOD-like receptor signaling pathway|Hepatitis C|Measles|Influenza A|Herpes simplex infection|Epstein-Barr virus infection OASL 212.106927942418 87.6443117095043 336.569544175331 3.84017556428403 1.94117226926206 0.336757325280489 1 1.20291 1.27266 8.74283 1.05621 GeneID:8638,Genbank:XM_017020140.1,HGNC:HGNC:8090,MIM:603281 2'-5'-oligoadenylate synthetase like GO:0003677,GO:0003723,GO:0003725,GO:0005524,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0009615,GO:0016020,GO:0016740,GO:0045071,GO:0046966,GO:0051607,GO:0060333,GO:0060337 DNA binding|RNA binding|double-stranded RNA binding|ATP binding|nucleoplasm|nucleolus|cytoplasm|cytosol|response to virus|membrane|transferase activity|negative regulation of viral genome replication|thyroid hormone receptor binding|defense response to virus|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway hsa05165 Human papillomavirus infection OAT 3314.07247184551 3459.57926108063 3168.56568261039 0.915881800499828 -0.126766672150188 0.355014463398117 1 28.768 28.2241 27.7482 25.6251 GeneID:4942,Genbank:NM_001322965.1,HGNC:HGNC:8091,MIM:613349 ornithine aminotransferase GO:0004587,GO:0005654,GO:0005739,GO:0005759,GO:0007601,GO:0008652,GO:0030170,GO:0034214,GO:0042802,GO:0055129 ornithine-oxo-acid transaminase activity|nucleoplasm|mitochondrion|mitochondrial matrix|visual perception|cellular amino acid biosynthetic process|pyridoxal phosphate binding|protein hexamerization|identical protein binding|L-proline biosynthetic process hsa00330 Arginine and proline metabolism OAZ1 18436.3570131986 18078.5107324881 18794.2032939091 1.03958802647028 0.0560119226747491 0.68994637570104 1 787.976 829.168 815.451 896.848 GeneID:4946,Genbank:NM_004152.3,HGNC:HGNC:8095,MIM:601579 ornithine decarboxylase antizyme 1 OAZ2 3063.312299562 2850.1662061217 3276.4583930023 1.14956748345587 0.201091159565837 0.145359660115979 1 64.351 69.5613 76.6811 79.0053 GeneID:4947,Genbank:NM_001301302.1,HGNC:HGNC:8096,MIM:604152 ornithine decarboxylase antizyme 2 GO:0005634,GO:0005737,GO:0005829,GO:0006521,GO:0006595,GO:0006596,GO:0008073,GO:0045732,GO:0090316,GO:1902268 nucleus|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|polyamine metabolic process|polyamine biosynthetic process|ornithine decarboxylase inhibitor activity|positive regulation of protein catabolic process|positive regulation of intracellular protein transport|negative regulation of polyamine transmembrane transport OAZ3 59.7907032633621 55.1369200469024 64.4444864798218 1.16880824001417 0.225038254186347 0.571532700504181 1 0.279739 0.464435 0.223921 0.839508 GeneID:51686,Genbank:NM_001134939.1,HGNC:HGNC:8097,MIM:605138 ornithine decarboxylase antizyme 3 GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0006595,GO:0006596,GO:0007283,GO:0008073,GO:0015489,GO:0045732,GO:0072562,GO:1902268 nucleus|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|polyamine metabolic process|polyamine biosynthetic process|spermatogenesis|ornithine decarboxylase inhibitor activity|putrescine transmembrane transporter activity|positive regulation of protein catabolic process|blood microparticle|negative regulation of polyamine transmembrane transport OBSCN 32.935742669706 34.3716247210614 31.4998606183505 0.916449567746177 -0.125872603499617 0.827850049629197 1 0.0355272 0.0319829 0.0275592 0.0339459 GeneID:84033,Genbank:XM_017002470.2,HGNC:HGNC:15719,MIM:608616 obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF GO:0004674,GO:0005085,GO:0005089,GO:0005516,GO:0005524,GO:0005829,GO:0005886,GO:0007186,GO:0007275,GO:0008307,GO:0016604,GO:0030016,GO:0030018,GO:0030506,GO:0031430,GO:0031432,GO:0035023,GO:0036309,GO:0042383,GO:0043065,GO:0045214,GO:0046872,GO:0051056 protein serine/threonine kinase activity|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|calmodulin binding|ATP binding|cytosol|plasma membrane|G-protein coupled receptor signaling pathway|multicellular organism development|structural constituent of muscle|nuclear body|myofibril|Z disc|ankyrin binding|M band|titin binding|regulation of Rho protein signal transduction|protein localization to M-band|sarcolemma|positive regulation of apoptotic process|sarcomere organization|metal ion binding|regulation of small GTPase mediated signal transduction OBSL1 1106.32588750825 1068.49123773083 1144.16053728567 1.07081883021853 0.0987144139307265 0.537545443669093 1 5.65533 6.30039 6.28388 6.60496 GeneID:23363,Genbank:XM_011510857.2,HGNC:HGNC:29092,MIM:610991 obscurin like 1 GO:0000226,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005859,GO:0006941,GO:0007010,GO:0007015,GO:0007030,GO:0007088,GO:0008093,GO:0008307,GO:0014704,GO:0030018,GO:0031430,GO:0034067,GO:0043687,GO:0045214,GO:0048471,GO:0050775,GO:0051015,GO:0051371,GO:0055003,GO:0071688,GO:0097493,GO:1990393 microtubule cytoskeleton organization|cytoplasm|Golgi apparatus|centrosome|cytosol|muscle myosin complex|striated muscle contraction|cytoskeleton organization|actin filament organization|Golgi organization|regulation of mitotic nuclear division|cytoskeletal adaptor activity|structural constituent of muscle|intercalated disc|Z disc|M band|protein localization to Golgi apparatus|post-translational protein modification|sarcomere organization|perinuclear region of cytoplasm|positive regulation of dendrite morphogenesis|actin filament binding|muscle alpha-actinin binding|cardiac myofibril assembly|striated muscle myosin thick filament assembly|structural molecule activity conferring elasticity|3M complex OCA2 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00869713 0 0 0 GeneID:4948,Genbank:XM_017022264.1,HGNC:HGNC:8101,MIM:611409 OCA2 melanosomal transmembrane protein OCEL1 354.679844181311 333.319903565886 376.039784796737 1.12816480736322 0.173977838479404 0.44433933111469 1 7.82719 8.65117 8.73026 10.1416 GeneID:79629,Genbank:NM_024578.2,HGNC:HGNC:26221 occludin/ELL domain containing 1 OCIAD1 2864.15065254886 2917.01172853662 2811.2895765611 0.96375669287125 -0.0532591209350382 0.715883985960339 1 34.5018 31.4675 32.9837 31.966 GeneID:54940,Genbank:XM_024454108.1,HGNC:HGNC:16074 OCIA domain containing 1 GO:0005739,GO:0005768,GO:0016020,GO:2000736 mitochondrion|endosome|membrane|regulation of stem cell differentiation OCIAD2 5253.97721540766 5363.71526203191 5144.23916878341 0.959081330285725 -0.0602749336327549 0.751359781686482 1 146.243 155.938 129.799 157.619 GeneID:132299,Genbank:NM_001286774.1,HGNC:HGNC:28685 OCIA domain containing 2 GO:0005743,GO:0005768 mitochondrial inner membrane|endosome OCLM 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0874147 0 0 0 GeneID:10896,Genbank:NM_022375.3,HGNC:HGNC:8103,MIM:604301 oculomedin GO:0007601 visual perception OCLN 141.135263992208 158.193959280294 124.076568704121 0.78433190033684 -0.35046381600105 0.179738673773507 1 1.09227 1.06327 0.955928 0.754622 GeneID:100506658,Genbank:NM_002538.3,HGNC:HGNC:8104,MIM:602876 occludin hsa04514,hsa04530,hsa04670,hsa05130,hsa05160 Cell adhesion molecules (CAMs)|Tight junction|Leukocyte transendothelial migration|Pathogenic Escherichia coli infection|Hepatitis C OCRL 1616.75055456337 1607.51935825409 1625.98175087265 1.01148502039727 0.0164749544403469 0.906402985951208 1 8.82274 8.6017 9.50601 8.43126 GeneID:4952,Genbank:XM_011531344.3,HGNC:HGNC:8108,MIM:300535 OCRL, inositol polyphosphate-5-phosphatase hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system ODAM 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0289396 0 0 0 GeneID:54959,Genbank:XM_005265698.3,HGNC:HGNC:26043,MIM:614843 odontogenic, ameloblast associated GO:0001934,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0006954,GO:0010628,GO:0031214,GO:0032956,GO:0042475,GO:0043547,GO:0044267,GO:0060054,GO:0071944,GO:0099512 positive regulation of protein phosphorylation|extracellular region|extracellular space|nucleus|cytoplasm|inflammatory response|positive regulation of gene expression|biomineral tissue development|regulation of actin cytoskeleton organization|odontogenesis of dentin-containing tooth|positive regulation of GTPase activity|cellular protein metabolic process|positive regulation of epithelial cell proliferation involved in wound healing|cell periphery|supramolecular fiber ODAPH 3.99824294517971 4.60274771635603 3.3937381740034 0.737328739948885 -0.439620102770969 0.848001154774604 1 0.0585871 0.069491 0.0560437 0.0130389 GeneID:152816,Genbank:XM_011531668.2,HGNC:HGNC:26300,MIM:614829 odontogenesis associated phosphoprotein GO:0005576,GO:0070169,GO:0070175 extracellular region|positive regulation of biomineral tissue development|positive regulation of enamel mineralization ODC1 4711.48911374989 5275.9934980824 4146.98472941738 0.786010204698819 -0.347380051903721 0.0463932987492539 0.79332376136203 85.6242 89.4705 63.223 75.9164 GeneID:4953,Genbank:NM_001287188.1,HGNC:HGNC:8109,MIM:165640 ornithine decarboxylase 1 hsa00330,hsa00480 Arginine and proline metabolism|Glutathione metabolism ODF2 1176.67765477336 1176.15879933397 1177.19651021275 1.00088228807144 0.00127231143520235 0.990152832939693 1 6.29487 6.21377 6.48595 6.16374 GeneID:4957,Genbank:NM_001351584.1,HGNC:HGNC:8114,MIM:602015 outer dense fiber of sperm tails 2 GO:0000922,GO:0001520,GO:0005634,GO:0005813,GO:0005814,GO:0005874,GO:0005929,GO:0007275,GO:0007286,GO:0008104,GO:0010457,GO:0017137,GO:0036064,GO:0097539,GO:0120103,GO:1902017 spindle pole|outer dense fiber|nucleus|centrosome|centriole|microtubule|cilium|multicellular organism development|spermatid development|protein localization|centriole-centriole cohesion|Rab GTPase binding|ciliary basal body|ciliary transition fiber|centriolar subdistal appendage|regulation of cilium assembly ODF2L 97.5203936403453 93.2556111942441 101.785176086447 1.09146436104993 0.126265023616889 0.70885279440291 1 0.253307 0.250337 0.316369 0.241958 GeneID:57489,Genbank:NM_001184766.1,HGNC:HGNC:29225 outer dense fiber of sperm tails 2 like GO:0005813 centrosome ODF3B 4.30857501470882 4.25675513845349 4.36039489096415 1.02434712571894 0.0347046915976304 1 1 0.251801 0 0 0.14109 GeneID:440836,Genbank:NM_001014440.3,HGNC:HGNC:34388 outer dense fiber of sperm tails 3B ODF3L1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0173417 GeneID:161753,Genbank:XM_006720414.3,HGNC:HGNC:28735 outer dense fiber of sperm tails 3 like 1 ODF3L2 1.94527630971887 0.980142803914724 2.91040981552302 2.96937324224464 1.5701584476161 0.688953432662636 1 0 0.0334342 0.0718336 0 GeneID:284451,Genbank:XM_017026671.2,HGNC:HGNC:26841 outer dense fiber of sperm tails 3 like 2 GO:0005881 cytoplasmic microtubule ODR4 152.014207665527 162.008669291475 142.01974603958 0.876618187537036 -0.189979483561539 0.470807608363955 1 0.898534 0.986351 1.0235 0.660556 GeneID:54953,Genbank:NM_017847.5,HGNC:HGNC:24299,MIM:609335 odr-4 GPCR localization factor homolog GO:0016021 integral component of membrane OFD1 130.682415633183 138.254919279205 123.109911987161 0.890455924671593 -0.167383891568775 0.559629809114446 1 0.522076 0.450252 0.465152 0.387852 GeneID:8481,Genbank:NM_003611.2,HGNC:HGNC:2567,MIM:300170 OFD1, centriole and centriolar satellite protein OGDH 5431.34388121771 5408.76361339241 5453.924149043 1.00834951180687 0.0119957891863696 0.94256726375471 1 31.8364 32.9686 33.701 32.9984 GeneID:4967,Genbank:NM_001165036.1,HGNC:HGNC:8124,MIM:613022 oxoglutarate dehydrogenase hsa00020,hsa00310,hsa00380 Citrate cycle (TCA cycle)|Lysine degradation|Tryptophan metabolism OGDHL 335.735602044926 333.703096762511 337.76810732734 1.01218151885394 0.017468037924804 0.912225685369475 1 2.64113 2.05846 2.36835 2.65832 GeneID:55753,Genbank:NM_001347822.1,HGNC:HGNC:25590,MIM:617513 oxoglutarate dehydrogenase like GO:0004591,GO:0005739,GO:0005759,GO:0006096,GO:0006099,GO:0030976,GO:0045252,GO:0046872 oxoglutarate dehydrogenase (succinyl-transferring) activity|mitochondrion|mitochondrial matrix|glycolytic process|tricarboxylic acid cycle|thiamine pyrophosphate binding|oxoglutarate dehydrogenase complex|metal ion binding hsa00020,hsa00310,hsa00380 Citrate cycle (TCA cycle)|Lysine degradation|Tryptophan metabolism OGFOD1 1545.1424840036 1592.79759888515 1497.48736912204 0.940161744448998 -0.0890191169898076 0.549623797322797 1 15.1337 14.8416 14.201 13.8559 GeneID:55239,Genbank:NM_001324360.1,HGNC:HGNC:25585,MIM:615857 2-oxoglutarate and iron dependent oxygenase domain containing 1 GO:0005506,GO:0005634,GO:0005829,GO:0006449,GO:0008283,GO:0010494,GO:0018126,GO:0019511,GO:0031418,GO:0031543,GO:0031544,GO:0034063 iron ion binding|nucleus|cytosol|regulation of translational termination|cell proliferation|cytoplasmic stress granule|protein hydroxylation|peptidyl-proline hydroxylation|L-ascorbic acid binding|peptidyl-proline dioxygenase activity|peptidyl-proline 3-dioxygenase activity|stress granule assembly OGFOD2 266.696638325375 258.138082313417 275.255194337333 1.06630990619638 0.0926267956534245 0.669359181280081 1 2.55987 2.82941 2.84526 3.02899 GeneID:79676,Genbank:NM_024623.2,HGNC:HGNC:25823 2-oxoglutarate and iron dependent oxygenase domain containing 2 GO:0005506,GO:0016705,GO:0031418,GO:0051213 iron ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|L-ascorbic acid binding|dioxygenase activity OGFOD3 1250.55637103531 1250.79271425469 1250.32002781593 0.999622090508387 -0.00054531119508479 1 1 11.1512 10.4254 10.9546 11.1834 GeneID:79701,Genbank:NM_024648.2,HGNC:HGNC:26174 2-oxoglutarate and iron dependent oxygenase domain containing 3 GO:0005506,GO:0016020,GO:0016021,GO:0016705,GO:0031418,GO:0051213,GO:0070062 iron ion binding|membrane|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|L-ascorbic acid binding|dioxygenase activity|extracellular exosome OGFR 1989.29316225404 1113.98061721774 2864.60570729034 2.57150408455483 1.3626124452565 0.000151253017918133 0.0299070164811952 14.2093 16.0326 47.8672 33.0615 GeneID:11054,Genbank:NM_007346.3,HGNC:HGNC:15768,MIM:606459 opioid growth factor receptor OGFRL1 825.861181214518 753.138245901382 898.584116527653 1.19311975114502 0.254738850839305 0.143170801210028 1 2.83971 2.53524 3.56533 2.77012 GeneID:79627,Genbank:XM_017011303.1,HGNC:HGNC:21378 opioid growth factor receptor like 1 GO:0004872,GO:0016020 receptor activity|membrane OGG1 946.27145934635 879.239466682732 1013.30345200997 1.15247721514714 0.204738228382011 0.187448858320942 1 5.71401 5.79493 6.73717 7.3495 GeneID:4968,Genbank:NM_016828.2,HGNC:HGNC:8125,MIM:601982 8-oxoguanine DNA glycosylase hsa03410 Base excision repair OGT 5158.26879484957 5069.11470587064 5247.42288382851 1.03517540799607 0.0498752496614357 0.693688409551738 1 26.8848 26.2866 30.6033 24.9837 GeneID:8473,Genbank:NM_181672.2,HGNC:HGNC:8127,MIM:300255 O-linked N-acetylglucosamine (GlcNAc) transferase hsa00514,hsa04931 Other types of O-glycan biosynthesis|Insulin resistance OIP5 469.552401574275 488.409738300165 450.695064848384 0.922780668577491 -0.115940313709459 0.510888044818682 1 21.9633 23.1245 21.86 21.0773 GeneID:11339,Genbank:NM_001317860.1,HGNC:HGNC:20300,MIM:606020 Opa interacting protein 5 GO:0000775,GO:0000785,GO:0005634,GO:0005654,GO:0005829,GO:0007049,GO:0007059,GO:0007154,GO:0010369,GO:0015030,GO:0016607,GO:0034080,GO:0042802,GO:0046872,GO:0051301 chromosome, centromeric region|chromatin|nucleus|nucleoplasm|cytosol|cell cycle|chromosome segregation|cell communication|chromocenter|Cajal body|nuclear speck|CENP-A containing nucleosome assembly|identical protein binding|metal ion binding|cell division OLA1 2454.26093593817 2566.85894351737 2341.66292835897 0.912267865078001 -0.132470596288274 0.343847589343078 1 22.4689 22.4488 20.5079 20.299 GeneID:29789,Genbank:NM_001011708.2,HGNC:HGNC:28833,MIM:611175 Obg like ATPase 1 GO:0002576,GO:0005524,GO:0005525,GO:0005576,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0016020,GO:0016887,GO:0031093,GO:0045296,GO:0046034,GO:0046872,GO:0070062 platelet degranulation|ATP binding|GTP binding|extracellular region|nucleolus|cytoplasm|centrosome|cytosol|membrane|ATPase activity|platelet alpha granule lumen|cadherin binding|ATP metabolic process|metal ion binding|extracellular exosome OLAH 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0208598 0 GeneID:55301,Genbank:XM_024448060.1,HGNC:HGNC:25625 oleoyl-ACP hydrolase GO:0004320,GO:0006633,GO:0008610,GO:0016295,GO:0016296 oleoyl-[acyl-carrier-protein] hydrolase activity|fatty acid biosynthetic process|lipid biosynthetic process|myristoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity hsa00061 Fatty acid biosynthesis OLFM2 22.67657873707 23.0617648564651 22.2913926176749 0.966595260875092 -0.0490161735013685 0.973846852993558 1 0.531288 0.456604 0.423461 0.481931 GeneID:93145,Genbank:NM_058164.3,HGNC:HGNC:17189,MIM:617492 olfactomedin 2 GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0007601,GO:0007626,GO:0009306,GO:0030054,GO:0032281,GO:0051152,GO:0097060,GO:1905174 extracellular region|nucleus|nucleoplasm|cytoplasm|visual perception|locomotory behavior|protein secretion|cell junction|AMPA glutamate receptor complex|positive regulation of smooth muscle cell differentiation|synaptic membrane|regulation of vascular smooth muscle cell dedifferentiation OLFM4 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0134481 0 0 GeneID:10562,Genbank:NM_006418.4,HGNC:HGNC:17190,MIM:614061 olfactomedin 4 OLFML2A 722.219169616569 647.237847806471 797.200491426667 1.23169634490385 0.30064662640786 0.0627499515036 0.893336198472584 3.64509 3.50343 4.53742 4.47202 GeneID:169611,Genbank:NM_182487.3,HGNC:HGNC:27270,MIM:615899 olfactomedin like 2A GO:0005578,GO:0030198,GO:0042803,GO:0050840 proteinaceous extracellular matrix|extracellular matrix organization|protein homodimerization activity|extracellular matrix binding OLFML2B 188.868163505011 155.25353086855 222.482796141472 1.43302889729345 0.519067702106416 0.101155597176568 1 0.521125 0.490012 0.918094 0.561626 GeneID:25903,Genbank:NM_015441.2,HGNC:HGNC:24558 olfactomedin like 2B GO:0005576 extracellular region OLIG1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0333344 GeneID:116448,Genbank:NM_138983.2,HGNC:HGNC:16983,MIM:606385 oligodendrocyte transcription factor 1 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046983,GO:0048663,GO:0048709 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|protein dimerization activity|neuron fate commitment|oligodendrocyte differentiation OLIG2 9.43244000621847 5.77499561901052 13.0898843934264 2.26664836772105 1.18056059862506 0.245459214459405 1 0.153201 0.0441265 0.423608 0.176261 GeneID:10215,Genbank:NM_005806.3,HGNC:HGNC:9398,MIM:606386 oligodendrocyte transcription factor 2 OMA1 179.907989597581 166.44772087356 193.368258321601 1.16173569278543 0.216281877622807 0.340158196594041 1 3.67289 2.695 3.85062 3.5492 GeneID:115209,Genbank:NM_145243.4,HGNC:HGNC:29661,MIM:617081 OMA1 zinc metallopeptidase GO:0002024,GO:0004222,GO:0005743,GO:0006006,GO:0006515,GO:0006629,GO:0006950,GO:0010637,GO:0016021,GO:0031966,GO:0034982,GO:0042407,GO:0042981,GO:0046872,GO:0097009 diet induced thermogenesis|metalloendopeptidase activity|mitochondrial inner membrane|glucose metabolic process|protein quality control for misfolded or incompletely synthesized proteins|lipid metabolic process|response to stress|negative regulation of mitochondrial fusion|integral component of membrane|mitochondrial membrane|mitochondrial protein processing|cristae formation|regulation of apoptotic process|metal ion binding|energy homeostasis OMP 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0 0 0 GeneID:4975,Genbank:NM_006189.1,HGNC:HGNC:8136,MIM:164340 olfactory marker protein GO:0004871,GO:0005634,GO:0005829,GO:0007165,GO:0007268,GO:0007608,GO:0022008,GO:0030424,GO:0043025 signal transducer activity|nucleus|cytosol|signal transduction|chemical synaptic transmission|sensory perception of smell|neurogenesis|axon|neuronal cell body ONECUT1 6.89834396339074 7.49514985341526 6.30153807336622 0.840748777090141 -0.250253319603863 0.8564994454388 1 0.0207252 0.0707085 0.0328452 0.0305985 GeneID:3175,Genbank:NM_004498.3,HGNC:HGNC:8138,MIM:604164 one cut homeobox 1 hsa04550,hsa04950 Signaling pathways regulating pluripotency of stem cells|Maturity onset diabetes of the young ONECUT2 11.3593724232631 13.5102768458505 9.20846800067565 0.681589881964848 -0.553024175619801 0.560274120039042 1 0.043502 0.0234217 0.0235496 0.0219391 GeneID:9480,Genbank:NM_004852.2,HGNC:HGNC:8139,MIM:604894 one cut homeobox 2 OOSP2 9.18884165077497 10.1376119619418 8.24007133960811 0.812821734600083 -0.298989115045343 0.788792971934284 1 0 0 0 0.0297905 GeneID:219990,Genbank:NM_173801.4,HGNC:HGNC:26699 oocyte secreted protein 2 GO:0005576 extracellular region OPA1 809.14367920065 796.252686616813 822.034671784487 1.0323791499872 0.045972910053022 0.854738448842159 1 4.96608 3.68694 5.15751 3.70851 GeneID:4976,Genbank:NM_001354664.1,HGNC:HGNC:8140,MIM:605290 OPA1, mitochondrial dynamin like GTPase GO:0000002,GO:0000266,GO:0000287,GO:0003374,GO:0003924,GO:0005525,GO:0005654,GO:0005739,GO:0005741,GO:0005743,GO:0005758,GO:0005829,GO:0006915,GO:0007005,GO:0007007,GO:0007601,GO:0008017,GO:0008053,GO:0010636,GO:0014042,GO:0014850,GO:0016020,GO:0016021,GO:0019896,GO:0019900,GO:0030061,GO:0030425,GO:0031314,GO:0036444,GO:0042981,GO:0043066,GO:0046039,GO:0048312,GO:0051259,GO:0051602,GO:0060041,GO:0061003,GO:0070300,GO:0070584,GO:0071333,GO:0071456,GO:0090102,GO:0090201,GO:0090398,GO:0097749,GO:1901612,GO:1902236,GO:1904115,GO:1905232,GO:2001275 mitochondrial genome maintenance|mitochondrial fission|magnesium ion binding|dynamin family protein polymerization involved in mitochondrial fission|GTPase activity|GTP binding|nucleoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|apoptotic process|mitochondrion organization|inner mitochondrial membrane organization|visual perception|microtubule binding|mitochondrial fusion|positive regulation of mitochondrial fusion|positive regulation of neuron maturation|response to muscle activity|membrane|integral component of membrane|axonal transport of mitochondrion|kinase binding|mitochondrial crista|dendrite|extrinsic component of mitochondrial inner membrane|mitochondrial calcium uptake|regulation of apoptotic process|negative regulation of apoptotic process|GTP metabolic process|intracellular distribution of mitochondria|protein oligomerization|response to electrical stimulus|retina development in camera-type eye|positive regulation of dendritic spine morphogenesis|phosphatidic acid binding|mitochondrion morphogenesis|cellular response to glucose stimulus|cellular response to hypoxia|cochlea development|negative regulation of release of cytochrome c from mitochondria|cellular senescence|membrane tubulation|cardiolipin binding|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|axon cytoplasm|cellular response to L-glutamate|positive regulation of glucose import in response to insulin stimulus OPA3 2283.61839458265 2211.00963211997 2356.22715704533 1.06567928190621 0.0917733217543042 0.526901398618026 1 8.32933 9.10779 9.57614 9.44541 GeneID:80207,Genbank:NM_001017989.2,HGNC:HGNC:8142,MIM:606580 OPA3, outer mitochondrial membrane lipid metabolism regulator GO:0005739,GO:0007601,GO:0019216,GO:0040007,GO:0050896,GO:0050905,GO:0070584 mitochondrion|visual perception|regulation of lipid metabolic process|growth|response to stimulus|neuromuscular process|mitochondrion morphogenesis OPCML 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00206946 0 GeneID:4978,Genbank:XM_011542856.3,HGNC:HGNC:8143,MIM:600632 opioid binding protein/cell adhesion molecule like OPHN1 619.334908334852 526.211862834928 712.457953834776 1.35393746160807 0.437161102346003 0.00891116175725981 0.367800991734648 1.5468 1.70067 2.45826 1.94581 GeneID:4983,Genbank:NM_002547.2,HGNC:HGNC:8148,MIM:300127 oligophrenin 1 GO:0003779,GO:0005096,GO:0005543,GO:0005829,GO:0006930,GO:0007165,GO:0007399,GO:0007411,GO:0015629,GO:0021707,GO:0021895,GO:0030036,GO:0030054,GO:0030100,GO:0030182,GO:0031175,GO:0034329,GO:0035023,GO:0035255,GO:0043195,GO:0043197,GO:0045198,GO:0048488,GO:0048667,GO:0051056,GO:0051966,GO:1901799 actin binding|GTPase activator activity|phospholipid binding|cytosol|substrate-dependent cell migration, cell extension|signal transduction|nervous system development|axon guidance|actin cytoskeleton|cerebellar granule cell differentiation|cerebral cortex neuron differentiation|actin cytoskeleton organization|cell junction|regulation of endocytosis|neuron differentiation|neuron projection development|cell junction assembly|regulation of Rho protein signal transduction|ionotropic glutamate receptor binding|terminal bouton|dendritic spine|establishment of epithelial cell apical/basal polarity|synaptic vesicle endocytosis|cell morphogenesis involved in neuron differentiation|regulation of small GTPase mediated signal transduction|regulation of synaptic transmission, glutamatergic|negative regulation of proteasomal protein catabolic process OPLAH 23.4185018429096 16.7966978354972 30.040305850322 1.78846497951738 0.83872186875457 0.162324075664303 1 0.111178 0.197496 0.190954 0.32041 GeneID:26873,Genbank:XM_011516960.1,HGNC:HGNC:8149,MIM:614243 5-oxoprolinase, ATP-hydrolysing GO:0005524,GO:0005829,GO:0006749,GO:0006750,GO:0017168 ATP binding|cytosol|glutathione metabolic process|glutathione biosynthetic process|5-oxoprolinase (ATP-hydrolyzing) activity hsa00480 Glutathione metabolism OPN1SW 5.35988725859756 6.36111957033777 4.35865494685735 0.685202486553151 -0.545397708013916 0.822104142666669 1 0 0 0 0.178711 GeneID:611,Genbank:NM_001708.2,HGNC:HGNC:1012,MIM:613522 opsin 1, short wave sensitive OPN3 543.208302726146 546.035232976432 540.38137247586 0.989645612299133 -0.0150160999072689 0.932246033227156 1 8.48198 9.17619 9.74147 8.32051 GeneID:23596,Genbank:NM_014322.2,HGNC:HGNC:14007,MIM:606695 opsin 3 GO:0001750,GO:0004930,GO:0005887,GO:0007186,GO:0007602,GO:0008020,GO:0009583,GO:0009881,GO:0016021,GO:0018298,GO:0042752 photoreceptor outer segment|G-protein coupled receptor activity|integral component of plasma membrane|G-protein coupled receptor signaling pathway|phototransduction|G-protein coupled photoreceptor activity|detection of light stimulus|photoreceptor activity|integral component of membrane|protein-chromophore linkage|regulation of circadian rhythm OPN4 1.97679409611663 2.49838328447175 1.45520490776151 0.582458631069969 -0.77977250841594 0.825694118379557 1 1.48664e-06 0.0333515 0.0174018 0 GeneID:94233,Genbank:XM_017016957.1,HGNC:HGNC:14449,MIM:606665 opsin 4 OPRL1 14.7155255073486 15.3745099043101 14.0565411103872 0.914275719868416 -0.129298787698963 0.907119995832136 1 0.204219 0.150998 0.189104 0.138834 GeneID:4987,Genbank:NM_182647.3,HGNC:HGNC:8155,MIM:602548 opioid related nociceptin receptor 1 GO:0001626,GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0007193,GO:0007204,GO:0007218,GO:0007268,GO:0007600,GO:0008022,GO:0019233,GO:0031410,GO:0032355,GO:0035810,GO:0042755,GO:0042923,GO:0043005,GO:0044849,GO:0045776,GO:0060454,GO:0106072,GO:1901386,GO:1904058,GO:1904059 nociceptin receptor activity|G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|chemical synaptic transmission|sensory perception|protein C-terminus binding|sensory perception of pain|cytoplasmic vesicle|response to estradiol|positive regulation of urine volume|eating behavior|neuropeptide binding|neuron projection|estrous cycle|negative regulation of blood pressure|positive regulation of gastric acid secretion|negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway|negative regulation of voltage-gated calcium channel activity|positive regulation of sensory perception of pain|regulation of locomotor rhythm hsa04080 Neuroactive ligand-receptor interaction OPRM1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:4988,Genbank:NM_001145279.3,HGNC:HGNC:8156,MIM:600018 opioid receptor mu 1 hsa04080,hsa04915,hsa05032 Neuroactive ligand-receptor interaction|Estrogen signaling pathway|Morphine addiction OPTN 1445.86099953589 1397.99338028297 1493.72861878882 1.06848046625691 0.0955605331807977 0.504440818760549 1 10.5788 10.3288 11.9496 10.0906 GeneID:10133,Genbank:NM_001008211.1,HGNC:HGNC:17142,MIM:602432 optineurin GO:0000042,GO:0000086,GO:0000139,GO:0001920,GO:0005634,GO:0005654,GO:0005737,GO:0005776,GO:0005794,GO:0005802,GO:0005829,GO:0006914,GO:0007030,GO:0007165,GO:0008022,GO:0008219,GO:0010508,GO:0017137,GO:0030674,GO:0031410,GO:0031593,GO:0034620,GO:0042802,GO:0043001,GO:0043122,GO:0043124,GO:0045087,GO:0046872,GO:0048471,GO:0050829,GO:0055038,GO:0061734,GO:0070530,GO:0090161,GO:1904417 protein targeting to Golgi|G2/M transition of mitotic cell cycle|Golgi membrane|negative regulation of receptor recycling|nucleus|nucleoplasm|cytoplasm|autophagosome|Golgi apparatus|trans-Golgi network|cytosol|autophagy|Golgi organization|signal transduction|protein C-terminus binding|cell death|positive regulation of autophagy|Rab GTPase binding|protein binding, bridging|cytoplasmic vesicle|polyubiquitin modification-dependent protein binding|cellular response to unfolded protein|identical protein binding|Golgi to plasma membrane protein transport|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|metal ion binding|perinuclear region of cytoplasm|defense response to Gram-negative bacterium|recycling endosome membrane|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|K63-linked polyubiquitin modification-dependent protein binding|Golgi ribbon formation|positive regulation of xenophagy hsa04137 Mitophagy - animal OR13A1 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0077265 0 0 0.00691294 GeneID:79290,Genbank:XM_017016632.2,HGNC:HGNC:14772 olfactory receptor family 13 subfamily A member 1 hsa04740 Olfactory transduction OR13C5 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:138799,Genbank:NM_001004482.1,HGNC:HGNC:15100 olfactory receptor family 13 subfamily C member 5 hsa04740 Olfactory transduction OR1B1 1.21386734807293 0.490071401957362 1.93766329418849 3.95383873951713 1.98325403079315 0.683591311517638 1 0 0 0 0 GeneID:347169,Genbank:XM_017014695.1,HGNC:HGNC:8181 olfactory receptor family 1 subfamily B member 1 (gene/pseudogene) hsa04740 Olfactory transduction OR1F1 12.5689982775441 13.5102768458505 11.6277197092377 0.860657397469174 -0.216489037679383 0.854830762833281 1 0.177543 0.11413 0.0649685 0.109038 GeneID:4992,Genbank:XM_011522506.3,HGNC:HGNC:8194,MIM:603232 olfactory receptor family 1 subfamily F member 1 hsa04740 Olfactory transduction OR1L8 1.72838687339946 1.51824048055703 1.93853326624189 1.27682886279692 0.352565169253837 1 1 0.0162489 0.0305144 0.0308609 0.0287856 GeneID:138881,Genbank:XM_017014285.1,HGNC:HGNC:15110 olfactory receptor family 1 subfamily L member 8 hsa04740 Olfactory transduction OR2AE1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:81392,Genbank:NM_001005276.1,HGNC:HGNC:15087 olfactory receptor family 2 subfamily AE member 1 hsa04740 Olfactory transduction OR2B6 1.21093081236113 0 2.42186162472226 Inf Inf 0.339679181581212 1 0 0 0 0.124408 GeneID:26212,Genbank:NM_012367.1,HGNC:HGNC:8241 olfactory receptor family 2 subfamily B member 6 hsa04740 Olfactory transduction OR2J3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.052023 0 0 GeneID:442186,Genbank:NM_001005216.3,HGNC:HGNC:8261,MIM:615016 olfactory receptor family 2 subfamily J member 3 hsa04740 Olfactory transduction OR2K2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0261377 GeneID:26248,Genbank:XM_011518520.2,HGNC:HGNC:8264 olfactory receptor family 2 subfamily K member 2 hsa04740 Olfactory transduction OR2S2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0513931 0 GeneID:56656,Genbank:NM_019897.2,HGNC:HGNC:8276 olfactory receptor family 2 subfamily S member 2 (gene/pseudogene) hsa04740 Olfactory transduction OR5H15 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0 0 0 0 GeneID:403274,Genbank:NM_001005515.1,HGNC:HGNC:31287 olfactory receptor family 5 subfamily H member 15 hsa04740 Olfactory transduction ORAI1 495.683789237888 500.92127203274 490.446306443037 0.97908859899841 -0.0304886778039484 0.843558664917137 1 19.9611 21.012 21.4001 20.3534 GeneID:84876,Genbank:NM_032790.3,HGNC:HGNC:25896,MIM:610277 ORAI calcium release-activated calcium modulator 1 hsa04020,hsa04024,hsa04611,hsa04924,hsa04925,hsa04927,hsa04934,hsa05340 Calcium signaling pathway|cAMP signaling pathway|Platelet activation|Renin secretion|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome|Primary immunodeficiency ORAI2 3259.65555453586 3281.68166952184 3237.62943954988 0.986576324455511 -0.0194974284757563 0.865122276942153 1 12.4792 13.3699 12.5661 13.5412 GeneID:80228,Genbank:NM_001271818.1,HGNC:HGNC:21667,MIM:610929 ORAI calcium release-activated calcium modulator 2 GO:0002115,GO:0015279,GO:0016020,GO:0016021,GO:0030426 store-operated calcium entry|store-operated calcium channel activity|membrane|integral component of membrane|growth cone hsa04020 Calcium signaling pathway ORAI3 343.245596373535 324.488809675546 362.002383071524 1.11560821907383 0.157830468354249 0.424391996133539 1 7.40459 7.95854 8.62702 9.11166 GeneID:93129,Genbank:NM_152288.2,HGNC:HGNC:28185,MIM:610930 ORAI calcium release-activated calcium modulator 3 GO:0002115,GO:0015279,GO:0016020,GO:0016021 store-operated calcium entry|store-operated calcium channel activity|membrane|integral component of membrane hsa04020 Calcium signaling pathway ORAOV1 255.77516437067 266.815288724595 244.735040016744 0.917245189309067 -0.124620661920115 0.541542220757191 1 3.89564 4.45911 3.95735 3.77895 GeneID:220064,Genbank:NM_153451.2,HGNC:HGNC:17589,MIM:607224 oral cancer overexpressed 1 ORC1 896.622752132068 871.01309705308 922.232407211055 1.05880429390932 0.0824359507101336 0.586086426400372 1 7.26019 6.6557 7.66997 7.40179 GeneID:4998,Genbank:NM_001190818.1,HGNC:HGNC:8487,MIM:601902 origin recognition complex subunit 1 GO:0000082,GO:0000083,GO:0000784,GO:0000808,GO:0003677,GO:0003682,GO:0005524,GO:0005634,GO:0005654,GO:0005664,GO:0005730,GO:0005829,GO:0005886,GO:0006260,GO:0006270 G1/S transition of mitotic cell cycle|regulation of transcription involved in G1/S transition of mitotic cell cycle|nuclear chromosome, telomeric region|origin recognition complex|DNA binding|chromatin binding|ATP binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|nucleolus|cytosol|plasma membrane|DNA replication|DNA replication initiation hsa04110 Cell cycle ORC2 555.634538863733 582.510205128523 528.758872598943 0.907724650905094 -0.139673357963392 0.434273580681548 1 5.70093 5.04822 5.42345 4.62979 GeneID:4999,Genbank:NM_006190.4,HGNC:HGNC:8488,MIM:601182 origin recognition complex subunit 2 hsa04110 Cell cycle ORC3 458.589216921893 485.833902775685 431.344531068101 0.887843620224375 -0.171622504116388 0.346085816258596 1 3.73079 3.53604 3.74415 3.12386 GeneID:23595,Genbank:NM_181837.2,HGNC:HGNC:8489,MIM:604972 origin recognition complex subunit 3 hsa04110 Cell cycle ORC4 324.842448432506 348.722822434666 300.962074430346 0.863040945611562 -0.212499087476835 0.27216834309141 1 1.51262 1.48652 1.50229 1.26492 GeneID:5000,Genbank:NM_181742.3,HGNC:HGNC:8490,MIM:603056 origin recognition complex subunit 4 hsa04110 Cell cycle ORC5 542.58345983286 566.108543146468 519.058376519253 0.916888435624541 -0.125181893414896 0.464909865189556 1 4.40042 4.78807 4.36376 3.8953 GeneID:5001,Genbank:NM_002553.3,HGNC:HGNC:8491,MIM:602331 origin recognition complex subunit 5 GO:0000082,GO:0000166,GO:0000784,GO:0000808,GO:0003688,GO:0005524,GO:0005634,GO:0005654,GO:0005664,GO:0005829,GO:0006260,GO:0006270 G1/S transition of mitotic cell cycle|nucleotide binding|nuclear chromosome, telomeric region|origin recognition complex|DNA replication origin binding|ATP binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|cytosol|DNA replication|DNA replication initiation hsa04110 Cell cycle ORC6 1582.13774509114 1698.31582078429 1465.95966939798 0.863184368571089 -0.212259355628118 0.140119356709967 1 29.1492 29.958 25.7338 25.9803 GeneID:23594,Genbank:NM_014321.3,HGNC:HGNC:17151,MIM:607213 origin recognition complex subunit 6 GO:0000082,GO:0000808,GO:0001650,GO:0003688,GO:0005634,GO:0005654,GO:0005664,GO:0006260,GO:0006270,GO:0016020,GO:0051782 G1/S transition of mitotic cell cycle|origin recognition complex|fibrillar center|DNA replication origin binding|nucleus|nucleoplasm|nuclear origin of replication recognition complex|DNA replication|DNA replication initiation|membrane|negative regulation of cell division hsa04110 Cell cycle ORM1 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0418846 0 0.0406696 GeneID:5004,Genbank:NM_000607.2,HGNC:HGNC:8498,MIM:138600 orosomucoid 1 GO:0002576,GO:0002682,GO:0005576,GO:0005615,GO:0006953,GO:0006954,GO:0031012,GO:0031093,GO:0032715,GO:0032720,GO:0035580,GO:0043312,GO:0050716,GO:0050718,GO:0070062,GO:0072562,GO:1904469,GO:1904724 platelet degranulation|regulation of immune system process|extracellular region|extracellular space|acute-phase response|inflammatory response|extracellular matrix|platelet alpha granule lumen|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|specific granule lumen|neutrophil degranulation|positive regulation of interleukin-1 secretion|positive regulation of interleukin-1 beta secretion|extracellular exosome|blood microparticle|positive regulation of tumor necrosis factor secretion|tertiary granule lumen ORMDL1 1099.58166815478 1152.78824251833 1046.37509379124 0.907690636664868 -0.139727419616431 0.373224271809077 1 13.0449 11.5119 12.1322 10.2543 GeneID:94101,Genbank:XM_011512199.3,HGNC:HGNC:16036,MIM:610073 ORMDL sphingolipid biosynthesis regulator 1 GO:0005783,GO:0005789,GO:0006672,GO:0016021,GO:0035339,GO:0090156,GO:1900060 endoplasmic reticulum|endoplasmic reticulum membrane|ceramide metabolic process|integral component of membrane|SPOTS complex|cellular sphingolipid homeostasis|negative regulation of ceramide biosynthetic process ORMDL2 641.229640980063 660.249261596111 622.210020364014 0.942386544832872 -0.0856091540227525 0.613236210025506 1 19.6841 22.8821 18.1432 21.7407 GeneID:29095,Genbank:NM_014182.4,HGNC:HGNC:16037,MIM:610074 ORMDL sphingolipid biosynthesis regulator 2 GO:0005783,GO:0006672,GO:0016021,GO:0035339,GO:0090156,GO:1900060 endoplasmic reticulum|ceramide metabolic process|integral component of membrane|SPOTS complex|cellular sphingolipid homeostasis|negative regulation of ceramide biosynthetic process ORMDL3 1525.99600476463 1480.84385617823 1571.14815335102 1.06098164691438 0.0853997004236305 0.560665468903093 1 17.1957 17.6625 18.908 18.691 GeneID:94103,Genbank:NM_001320802.1,HGNC:HGNC:16038,MIM:610075 ORMDL sphingolipid biosynthesis regulator 3 GO:0005783,GO:0005886,GO:0006672,GO:0016021,GO:0030667,GO:0035339,GO:0035579,GO:0043312,GO:0090156,GO:1900060 endoplasmic reticulum|plasma membrane|ceramide metabolic process|integral component of membrane|secretory granule membrane|SPOTS complex|specific granule membrane|neutrophil degranulation|cellular sphingolipid homeostasis|negative regulation of ceramide biosynthetic process OS9 4707.92011434383 4502.35748019221 4913.48274849546 1.09131333309537 0.126065381406866 0.347531397332906 1 42.8092 44.2861 47.2993 48.888 GeneID:10956,Genbank:NM_001261420.1,HGNC:HGNC:16994,MIM:609677 OS9, endoplasmic reticulum lectin GO:0000836,GO:0002020,GO:0005783,GO:0005788,GO:0005789,GO:0006605,GO:0006621,GO:0016567,GO:0030246,GO:0030433,GO:0034976,GO:0042787,GO:0044322,GO:0055085,GO:1904153,GO:1904380 Hrd1p ubiquitin ligase complex|protease binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|protein targeting|protein retention in ER lumen|protein ubiquitination|carbohydrate binding|ubiquitin-dependent ERAD pathway|response to endoplasmic reticulum stress|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|endoplasmic reticulum quality control compartment|transmembrane transport|negative regulation of retrograde protein transport, ER to cytosol|endoplasmic reticulum mannose trimming hsa04141 Protein processing in endoplasmic reticulum OSBP 1800.97309372077 1709.89422098679 1892.05196645475 1.10653158729482 0.146044635217687 0.300710469189753 1 12.4818 12.491 14.8056 13.1241 GeneID:5007,Genbank:NM_002556.2,HGNC:HGNC:8503,MIM:167040 oxysterol binding protein GO:0000139,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005789,GO:0005794,GO:0005829,GO:0006699,GO:0008142,GO:0015248,GO:0015918,GO:0016020,GO:0019904,GO:0030054,GO:0044128,GO:0048471,GO:0070273 Golgi membrane|nucleus|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum membrane|Golgi apparatus|cytosol|bile acid biosynthetic process|oxysterol binding|sterol transporter activity|sterol transport|membrane|protein domain specific binding|cell junction|positive regulation of growth of symbiont in host|perinuclear region of cytoplasm|phosphatidylinositol-4-phosphate binding OSBP2 176.950971323641 153.754907698208 200.147034949074 1.30172778186648 0.380427782749213 0.116686523009907 1 1.00012 1.11366 1.41166 1.42089 GeneID:23762,Genbank:NM_001282738.1,HGNC:HGNC:8504,MIM:606729 oxysterol binding protein 2 GO:0006869,GO:0007286,GO:0015485,GO:0016020,GO:0097440 lipid transport|spermatid development|cholesterol binding|membrane|apical dendrite OSBPL10 2561.65516240202 2379.79981479713 2743.51051000691 1.15283247479401 0.2051828812953 0.135206550442002 1 10.5143 10.4955 12.718 11.9952 GeneID:114884,Genbank:NM_001174060.1,HGNC:HGNC:16395,MIM:606738 oxysterol binding protein like 10 GO:0001786,GO:0005548,GO:0005829,GO:0005856,GO:0015485,GO:0036150 phosphatidylserine binding|phospholipid transporter activity|cytosol|cytoskeleton|cholesterol binding|phosphatidylserine acyl-chain remodeling OSBPL11 338.732050962803 346.454761868511 331.009340057096 0.955418647652253 -0.0657950595970394 0.742861063533189 1 2.73528 2.76341 2.75068 2.53297 GeneID:114885,Genbank:NM_022776.4,HGNC:HGNC:16397,MIM:606739 oxysterol binding protein like 11 GO:0005654,GO:0005794,GO:0006869,GO:0008289,GO:0010890,GO:0031902,GO:0045444 nucleoplasm|Golgi apparatus|lipid transport|lipid binding|positive regulation of sequestering of triglyceride|late endosome membrane|fat cell differentiation OSBPL1A 274.199284754877 224.188885409412 324.209684100341 1.44614521593375 0.532212429044529 0.00921099542896116 0.375761179990686 1.19677 1.16003 1.87351 1.7813 GeneID:114876,Genbank:NM_080597.3,HGNC:HGNC:16398,MIM:606730 oxysterol binding protein like 1A GO:0005543,GO:0005770,GO:0005829,GO:0006699,GO:0008203,GO:0015248,GO:0015485,GO:0016192,GO:0019886,GO:0070062 phospholipid binding|late endosome|cytosol|bile acid biosynthetic process|cholesterol metabolic process|sterol transporter activity|cholesterol binding|vesicle-mediated transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|extracellular exosome OSBPL2 1008.09540853253 966.951421977137 1049.23939508793 1.08510042101447 0.117828563587285 0.453266215636546 1 4.3954 4.68949 5.28286 4.77505 GeneID:9885,Genbank:NM_144498.2,HGNC:HGNC:15761,MIM:606731 oxysterol binding protein like 2 GO:0005829,GO:0006699,GO:0015248,GO:0015485 cytosol|bile acid biosynthetic process|sterol transporter activity|cholesterol binding OSBPL3 1434.26122280713 1409.60999810503 1458.91244750922 1.03497595041924 0.0495972444260369 0.795417225436181 1 7.04916 6.77345 8.48966 5.99489 GeneID:26031,Genbank:NM_015550.3,HGNC:HGNC:16370,MIM:606732 oxysterol binding protein like 3 GO:0005789,GO:0005829,GO:0005886,GO:0006699,GO:0015248,GO:0015485,GO:0016020,GO:0031965,GO:0032433,GO:0097038 endoplasmic reticulum membrane|cytosol|plasma membrane|bile acid biosynthetic process|sterol transporter activity|cholesterol binding|membrane|nuclear membrane|filopodium tip|perinuclear endoplasmic reticulum OSBPL5 171.683545048189 141.772679988023 201.594410108355 1.42195527463674 0.507876087971013 0.071653948852412 0.928200388965456 0.620431 0.889295 1.06757 1.15256 GeneID:114879,Genbank:NM_145638.2,HGNC:HGNC:16392,MIM:606733 oxysterol binding protein like 5 GO:0001786,GO:0005548,GO:0005789,GO:0005829,GO:0006893,GO:0008142,GO:0008203,GO:0015485,GO:0015914,GO:0016020,GO:0016021,GO:0030301,GO:0036150,GO:0043231,GO:0070273 phosphatidylserine binding|phospholipid transporter activity|endoplasmic reticulum membrane|cytosol|Golgi to plasma membrane transport|oxysterol binding|cholesterol metabolic process|cholesterol binding|phospholipid transport|membrane|integral component of membrane|cholesterol transport|phosphatidylserine acyl-chain remodeling|intracellular membrane-bounded organelle|phosphatidylinositol-4-phosphate binding hsa04979 Cholesterol metabolism OSBPL6 365.812030924782 330.782285660983 400.84177618858 1.2117994027026 0.277150899571528 0.218433429387521 1 1.08021 1.15421 1.64257 1.11123 GeneID:114880,Genbank:XM_017003267.2,HGNC:HGNC:16388,MIM:606734 oxysterol binding protein like 6 GO:0005789,GO:0005829,GO:0005886,GO:0006869,GO:0008289,GO:0031965,GO:0097038 endoplasmic reticulum membrane|cytosol|plasma membrane|lipid transport|lipid binding|nuclear membrane|perinuclear endoplasmic reticulum OSBPL7 153.97362303002 163.546527082248 144.400718977792 0.882933569755187 -0.179623198565176 0.466661197726026 1 1.06775 1.18527 0.911228 1.1042 GeneID:114881,Genbank:XM_017024124.1,HGNC:HGNC:16387,MIM:606735 oxysterol binding protein like 7 GO:0005776,GO:0005789,GO:0005829,GO:0005886,GO:0006699,GO:0010506,GO:0015248,GO:0015485,GO:0071397,GO:0097038,GO:1901800 autophagosome|endoplasmic reticulum membrane|cytosol|plasma membrane|bile acid biosynthetic process|regulation of autophagy|sterol transporter activity|cholesterol binding|cellular response to cholesterol|perinuclear endoplasmic reticulum|positive regulation of proteasomal protein catabolic process OSBPL8 316.591182093394 336.518046659562 296.664317527227 0.881570306472589 -0.181852463793846 0.697818495708862 1 1.77124 1.33185 1.76137 0.959641 GeneID:114882,Genbank:NM_001003712.1,HGNC:HGNC:16396,MIM:606736 oxysterol binding protein like 8 GO:0001786,GO:0005548,GO:0005783,GO:0005789,GO:0005829,GO:0010891,GO:0015485,GO:0015914,GO:0016020,GO:0016021,GO:0030336,GO:0031965,GO:0032148,GO:0032541,GO:0036150,GO:0045444,GO:0046628,GO:0051897,GO:0070273,GO:0090204,GO:2001275 phosphatidylserine binding|phospholipid transporter activity|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|negative regulation of sequestering of triglyceride|cholesterol binding|phospholipid transport|membrane|integral component of membrane|negative regulation of cell migration|nuclear membrane|activation of protein kinase B activity|cortical endoplasmic reticulum|phosphatidylserine acyl-chain remodeling|fat cell differentiation|positive regulation of insulin receptor signaling pathway|positive regulation of protein kinase B signaling|phosphatidylinositol-4-phosphate binding|protein localization to nuclear pore|positive regulation of glucose import in response to insulin stimulus OSBPL9 1041.91714316958 1076.19505899063 1007.63922734853 0.936297949828539 -0.0949603959130756 0.557692926926901 1 7.71361 7.25295 8.00783 6.11041 GeneID:114883,Genbank:NM_148909.3,HGNC:HGNC:16386,MIM:606737 oxysterol binding protein like 9 GO:0005794,GO:0005829,GO:0006699,GO:0008289,GO:0015248,GO:0031902,GO:0043231 Golgi apparatus|cytosol|bile acid biosynthetic process|lipid binding|sterol transporter activity|late endosome membrane|intracellular membrane-bounded organelle OSCAR 4.37464258349642 2.45035700978681 6.29892815720603 2.5706164987583 1.36211439562154 0.410119740092341 1 0 0.0882506 0.0234576 0.110611 GeneID:126014,Genbank:NM_133168.4,HGNC:HGNC:29960,MIM:606862 osteoclast associated, immunoglobulin-like receptor GO:0005576,GO:0005886,GO:0016021,GO:0035580,GO:0043312,GO:0050776,GO:0070062,GO:1904724 extracellular region|plasma membrane|integral component of membrane|specific granule lumen|neutrophil degranulation|regulation of immune response|extracellular exosome|tertiary granule lumen hsa04380 Osteoclast differentiation OSCP1 97.9425440599877 85.8859398555226 109.999148264453 1.28075850889556 0.35699847656753 0.243896559134782 1 0.809184 0.901936 0.905724 1.61557 GeneID:127700,Genbank:NM_145047.4,HGNC:HGNC:29971,MIM:608854 organic solute carrier partner 1 GO:0009925,GO:1903955 basal plasma membrane|positive regulation of protein targeting to mitochondrion OSER1 929.530090043764 940.717888989757 918.342291097771 0.976214337843607 -0.0347301538667219 0.825140612679653 1 5.93617 6.27717 5.66236 5.92865 GeneID:51526,Genbank:NM_016470.7,HGNC:HGNC:16105 oxidative stress responsive serine rich 1 OSGEP 390.349769032584 415.784135261961 364.915402803207 0.877655908091097 -0.188272664227519 0.314703693541659 1 8.90361 8.09626 7.55091 7.86849 GeneID:55644,Genbank:NM_017807.3,HGNC:HGNC:18028,MIM:610107 O-sialoglycoprotein endopeptidase GO:0000408,GO:0002949,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0016607,GO:0046872,GO:0061711 EKC/KEOPS complex|tRNA threonylcarbamoyladenosine modification|nucleus|nucleoplasm|cytoplasm|plasma membrane|nuclear speck|metal ion binding|N(6)-L-threonylcarbamoyladenine synthase OSGEPL1 148.288279754185 162.844733271335 133.731826237035 0.821222913081312 -0.284154213997573 0.350300123219484 1 1.15006 1.30821 0.809445 1.25477 GeneID:64172,Genbank:NM_001354347.1,HGNC:HGNC:23075 O-sialoglycoprotein endopeptidase like 1 GO:0000408,GO:0002949,GO:0004222,GO:0005739,GO:0046872,GO:0061711 EKC/KEOPS complex|tRNA threonylcarbamoyladenosine modification|metalloendopeptidase activity|mitochondrion|metal ion binding|N(6)-L-threonylcarbamoyladenine synthase OSGIN1 185.572749519634 149.690257658495 221.455241380774 1.47942320926459 0.565034814147027 0.0170371664305872 0.540331203073832 2.86168 3.282 4.20927 5.00594 GeneID:29948,Genbank:NM_182981.2,HGNC:HGNC:30093,MIM:607975 oxidative stress induced growth inhibitor 1 GO:0007275,GO:0008083,GO:0030154,GO:0030308,GO:0043065 multicellular organism development|growth factor activity|cell differentiation|negative regulation of cell growth|positive regulation of apoptotic process OSGIN2 497.067538041144 510.442317077176 483.692759005113 0.947595336089623 -0.0776569970024752 0.686000220468683 1 1.45418 1.30161 1.46425 1.16401 GeneID:734,Genbank:NM_004337.2,HGNC:HGNC:1355,MIM:604598 oxidative stress induced growth inhibitor family member 2 GO:0008083,GO:0030308,GO:0051321 growth factor activity|negative regulation of cell growth|meiotic cell cycle OSM 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0212416 0.022619 0 GeneID:5008,Genbank:NM_020530.5,HGNC:HGNC:8506,MIM:165095 oncostatin M GO:0002675,GO:0005125,GO:0005147,GO:0005576,GO:0005615,GO:0006955,GO:0007275,GO:0008083,GO:0008283,GO:0008284,GO:0008285,GO:0019221,GO:0033138,GO:0038165,GO:0040008,GO:0042531,GO:0043410,GO:0045944,GO:0046888,GO:0050731,GO:0051781 positive regulation of acute inflammatory response|cytokine activity|oncostatin-M receptor binding|extracellular region|extracellular space|immune response|multicellular organism development|growth factor activity|cell proliferation|positive regulation of cell proliferation|negative regulation of cell proliferation|cytokine-mediated signaling pathway|positive regulation of peptidyl-serine phosphorylation|oncostatin-M-mediated signaling pathway|regulation of growth|positive regulation of tyrosine phosphorylation of STAT protein|positive regulation of MAPK cascade|positive regulation of transcription from RNA polymerase II promoter|negative regulation of hormone secretion|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of cell division hsa04060,hsa04151,hsa04630 Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Jak-STAT signaling pathway OSMR 2376.50630784386 2276.79959349268 2476.21302219504 1.0875849720249 0.121128121816482 0.431615392213901 1 11.5146 11.2313 13.9545 10.7849 GeneID:9180,Genbank:NM_001323506.1,HGNC:HGNC:8507,MIM:601743 oncostatin M receptor GO:0002675,GO:0004896,GO:0005886,GO:0005900,GO:0008284,GO:0016324,GO:0019221,GO:0019838,GO:0034097,GO:0038165 positive regulation of acute inflammatory response|cytokine receptor activity|plasma membrane|oncostatin-M receptor complex|positive regulation of cell proliferation|apical plasma membrane|cytokine-mediated signaling pathway|growth factor binding|response to cytokine|oncostatin-M-mediated signaling pathway hsa04060,hsa04151,hsa04630 Cytokine-cytokine receptor interaction|PI3K-Akt signaling pathway|Jak-STAT signaling pathway OSR1 22.2382317510877 23.157817405835 21.3186460963404 0.92058097370475 -0.119383469211786 0.886795836116279 1 0.415462 0.363704 0.279759 0.409194 GeneID:130497,Genbank:NM_145260.2,HGNC:HGNC:8111,MIM:608891 odd-skipped related transciption factor 1 OSR2 61.2167010138504 64.774651951779 57.6587500759218 0.890143726574486 -0.167889796027165 0.671993849154865 1 1.12654 1.06005 0.875325 1.21012 GeneID:116039,Genbank:NM_001286841.1,HGNC:HGNC:15830,MIM:611297 odd-skipped related transciption factor 2 GO:0000122,GO:0001656,GO:0001823,GO:0002062,GO:0005634,GO:0008284,GO:0009790,GO:0010628,GO:0030154,GO:0030501,GO:0033687,GO:0035115,GO:0035116,GO:0036023,GO:0042474,GO:0042476,GO:0042733,GO:0043565,GO:0045893,GO:0045944,GO:0046872,GO:0048704,GO:0050679,GO:0060021,GO:0060272,GO:0060322,GO:0060349,GO:0061029,GO:0072498 negative regulation of transcription from RNA polymerase II promoter|metanephros development|mesonephros development|chondrocyte differentiation|nucleus|positive regulation of cell proliferation|embryo development|positive regulation of gene expression|cell differentiation|positive regulation of bone mineralization|osteoblast proliferation|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic skeletal limb joint morphogenesis|middle ear morphogenesis|odontogenesis|embryonic digit morphogenesis|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|embryonic skeletal system morphogenesis|positive regulation of epithelial cell proliferation|palate development|embryonic skeletal joint morphogenesis|head development|bone morphogenesis|eyelid development in camera-type eye|embryonic skeletal joint development OST4 2677.53749353225 2518.32734241765 2836.74764464684 1.12644118850868 0.171771992435508 0.388341388939602 1 255.744 277.542 278.493 325.439 GeneID:100128731,Genbank:NM_001134693.1,HGNC:HGNC:32483 oligosaccharyltransferase complex subunit 4, non-catalytic GO:0008250,GO:0016021,GO:0018279 oligosaccharyltransferase complex|integral component of membrane|protein N-linked glycosylation via asparagine OSTC 1093.53333542451 1079.22274829749 1107.84392255153 1.0265201732443 0.0377619796662202 0.801476258293201 1 36.7658 37.68 38.168 37.1059 GeneID:58505,Genbank:NM_001267818.1,HGNC:HGNC:24448 oligosaccharyltransferase complex non-catalytic subunit GO:0008250,GO:0016021,GO:0018279 oligosaccharyltransferase complex|integral component of membrane|protein N-linked glycosylation via asparagine OSTF1 392.378041959083 406.732527308411 378.023556609755 0.929415601725683 -0.105604231894383 0.572120905958898 1 7.54885 8.1275 7.91203 7.2495 GeneID:26578,Genbank:XM_011518525.3,HGNC:HGNC:8510,MIM:610180 osteoclast stimulating factor 1 GO:0001503,GO:0005576,GO:0005622,GO:0007165,GO:0017124,GO:0034774,GO:0043312,GO:0070062,GO:1904813 ossification|extracellular region|intracellular|signal transduction|SH3 domain binding|secretory granule lumen|neutrophil degranulation|extracellular exosome|ficolin-1-rich granule lumen OSTM1 2723.95270346673 3135.74116793875 2312.1642389947 0.737358128481816 -0.439562600813593 0.00156125690925058 0.138917170325319 35.4087 32.2904 25.5769 24.3487 GeneID:28962,Genbank:NM_014028.3,HGNC:HGNC:21652,MIM:607649 osteopetrosis associated transmembrane protein 1 GO:0005765,GO:0005829,GO:0016021,GO:0030316,GO:0034220 lysosomal membrane|cytosol|integral component of membrane|osteoclast differentiation|ion transmembrane transport OTOF 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00493892 0 0 0.00429358 GeneID:9381,Genbank:NM_001287489.1,HGNC:HGNC:8515,MIM:603681 otoferlin GO:0005509,GO:0005789,GO:0005829,GO:0007605,GO:0016021,GO:0016079,GO:0016323,GO:0030054,GO:0030672,GO:0061025 calcium ion binding|endoplasmic reticulum membrane|cytosol|sensory perception of sound|integral component of membrane|synaptic vesicle exocytosis|basolateral plasma membrane|cell junction|synaptic vesicle membrane|membrane fusion OTOGL 25.8710595952195 31.3831700346323 20.3589491558068 0.648721882886275 -0.624327989816999 0.272256325372776 1 0.124505 0.0907855 0.0870689 0.0576757 GeneID:283310,Genbank:XM_005268802.3,HGNC:HGNC:26901,MIM:614925 otogelin like GO:0005576,GO:0007605,GO:0046373,GO:0046556 extracellular region|sensory perception of sound|L-arabinose metabolic process|alpha-L-arabinofuranosidase activity OTOP2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0190386 0 0 GeneID:92736,Genbank:XM_011525479.2,HGNC:HGNC:19657,MIM:607827 otopetrin 2 GO:0016021 integral component of membrane OTP 0.969266633120943 0 1.93853326624189 Inf Inf 0.451830900262006 1 0 0 0.0428103 0.0401017 GeneID:23440,Genbank:NM_032109.2,HGNC:HGNC:8518,MIM:604529 orthopedia homeobox GO:0002052,GO:0005634,GO:0006351,GO:0006355,GO:0021879,GO:0021979,GO:0021985,GO:0043565 positive regulation of neuroblast proliferation|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|forebrain neuron differentiation|hypothalamus cell differentiation|neurohypophysis development|sequence-specific DNA binding OTUB1 2029.87343440864 2070.49544392887 1989.2514248884 0.960761073259693 -0.0577503957098406 0.674247076813669 1 41.8296 43.005 38.786 43.8924 GeneID:55611,Genbank:NM_017670.2,HGNC:HGNC:23077,MIM:608337 OTU deubiquitinase, ubiquitin aldehyde binding 1 GO:0002250,GO:0004843,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006974,GO:0016579,GO:0019784,GO:0031625,GO:0043130,GO:0070062,GO:0071108,GO:0071347,GO:1901315,GO:2000780 adaptive immune response|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|protein deubiquitination|NEDD8-specific protease activity|ubiquitin protein ligase binding|ubiquitin binding|extracellular exosome|protein K48-linked deubiquitination|cellular response to interleukin-1|negative regulation of histone H2A K63-linked ubiquitination|negative regulation of double-strand break repair OTUB2 67.146598482804 57.2412844787867 77.0519124868213 1.34608985784336 0.428774719857551 0.234809042869999 1 0.401191 0.469087 0.569023 0.60438 GeneID:78990,Genbank:XM_005268055.4,HGNC:HGNC:20351,MIM:608338 OTU deubiquitinase, ubiquitin aldehyde binding 2 GO:0004843,GO:0005634,GO:0016579,GO:0019784,GO:0035871,GO:0043130,GO:0070536,GO:0071108 thiol-dependent ubiquitin-specific protease activity|nucleus|protein deubiquitination|NEDD8-specific protease activity|protein K11-linked deubiquitination|ubiquitin binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination OTUD1 41.2496062716431 39.358582634897 43.1406299083892 1.09609205973131 0.13236897397381 0.765647775110676 1 0.887751 0.623999 1.05955 0.663252 GeneID:220213,Genbank:NM_001145373.2,HGNC:HGNC:27346,MIM:612022 OTU deubiquitinase 1 GO:0004843,GO:0070536 thiol-dependent ubiquitin-specific protease activity|protein K63-linked deubiquitination OTUD3 219.748377934776 252.901184371049 186.595571498502 0.737820077681942 -0.438659046464481 0.0454053318477544 0.792169711191323 1.60364 1.79833 1.35283 1.11664 GeneID:23252,Genbank:XM_005245793.4,HGNC:HGNC:29038,MIM:611758 OTU deubiquitinase 3 GO:0004843,GO:0005737,GO:0005829,GO:0016579,GO:0035871,GO:0036459,GO:0044313,GO:0050821,GO:0051898,GO:0071108,GO:1990167 thiol-dependent ubiquitin-specific protease activity|cytoplasm|cytosol|protein deubiquitination|protein K11-linked deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|protein K6-linked deubiquitination|protein stabilization|negative regulation of protein kinase B signaling|protein K48-linked deubiquitination|protein K27-linked deubiquitination OTUD4 468.248013619746 513.306310249766 423.189716989726 0.824438952998277 -0.278515424107938 0.454437013347362 1 2.56049 2.5758 2.78955 1.46215 GeneID:54726,Genbank:XM_005263079.4,HGNC:HGNC:24949,MIM:611744 OTU deubiquitinase 4 OTUD5 1528.66120150398 1418.85676215989 1638.46564084807 1.15477875184094 0.20761646705462 0.158049686775242 1 9.79476 10.7667 12.4192 13.0462 GeneID:55593,Genbank:NM_001136159.1,HGNC:HGNC:25402,MIM:300713 OTU deubiquitinase 5 GO:0004843,GO:0005829,GO:0016579,GO:0032480,GO:0032496,GO:0061578,GO:0070536,GO:0071108,GO:0101005,GO:1990380 thiol-dependent ubiquitin-specific protease activity|cytosol|protein deubiquitination|negative regulation of type I interferon production|response to lipopolysaccharide|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|ubiquitinyl hydrolase activity|Lys48-specific deubiquitinase activity hsa04622 RIG-I-like receptor signaling pathway OTUD6B 193.507892349014 221.757128708987 165.258655989041 0.74522364602723 -0.4242546430112 0.253168345777873 1 3.21942 2.41167 2.04981 1.96615 GeneID:51633,Genbank:NM_001286745.1,HGNC:HGNC:24281,MIM:612021 OTU domain containing 6B GO:0008283,GO:0016579,GO:0036459 cell proliferation|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity OTUD7A 2.72166664386287 1.56626675524197 3.87706653248377 2.4753551842354 1.30763554974577 0.556446753005391 1 0.00878327 0 0.00827493 0.0115932 GeneID:161725,Genbank:NM_130901.2,HGNC:HGNC:20718,MIM:612024 OTU deubiquitinase 7A GO:0003677,GO:0004843,GO:0005634,GO:0005737,GO:0005829,GO:0006955,GO:0008270,GO:0016579,GO:0035871,GO:0036459,GO:0043124,GO:0045088,GO:0050727,GO:0070530,GO:0070536,GO:0071108,GO:0071947 DNA binding|thiol-dependent ubiquitin-specific protease activity|nucleus|cytoplasm|cytosol|immune response|zinc ion binding|protein deubiquitination|protein K11-linked deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|negative regulation of I-kappaB kinase/NF-kappaB signaling|regulation of innate immune response|regulation of inflammatory response|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process OTUD7B 1015.22158773696 1010.7294388839 1019.71373659001 1.00888892453358 0.0127673470452149 0.935580559312471 1 3.50672 3.72807 4.03212 3.44365 GeneID:56957,Genbank:NM_020205.3,HGNC:HGNC:16683,MIM:611748 OTU deubiquitinase 7B GO:0000122,GO:0002250,GO:0002385,GO:0003677,GO:0004843,GO:0005634,GO:0005737,GO:0005829,GO:0006955,GO:0008234,GO:0008270,GO:0016579,GO:0032717,GO:0035871,GO:0036459,GO:0043124,GO:0070530,GO:0070536,GO:0071108,GO:0071947,GO:1900181,GO:1990380 negative regulation of transcription from RNA polymerase II promoter|adaptive immune response|mucosal immune response|DNA binding|thiol-dependent ubiquitin-specific protease activity|nucleus|cytoplasm|cytosol|immune response|cysteine-type peptidase activity|zinc ion binding|protein deubiquitination|negative regulation of interleukin-8 production|protein K11-linked deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|negative regulation of I-kappaB kinase/NF-kappaB signaling|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of protein localization to nucleus|Lys48-specific deubiquitinase activity OTULIN 997.912743116491 1141.92246178271 853.903024450269 0.747776712542459 -0.419320551777188 0.00590609211619553 0.306728378666673 3.08842 3.25621 2.37665 2.33752 GeneID:90268,Genbank:XM_011514151.2,HGNC:HGNC:25118,MIM:615712 OTU deubiquitinase with linear linkage specificity GO:0002040,GO:0004843,GO:0005737,GO:0005829,GO:0008234,GO:0010803,GO:0016567,GO:0032088,GO:0045087,GO:0050728,GO:0060070,GO:0070431,GO:0071797,GO:1990108 sprouting angiogenesis|thiol-dependent ubiquitin-specific protease activity|cytoplasm|cytosol|cysteine-type peptidase activity|regulation of tumor necrosis factor-mediated signaling pathway|protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|innate immune response|negative regulation of inflammatory response|canonical Wnt signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|LUBAC complex|protein linear deubiquitination OTULINL 123.504723628818 131.653668335442 115.355778922193 0.87620634032222 -0.190657440694053 0.500814650823598 1 0.74364 0.723837 0.760558 0.548213 GeneID:54491,Genbank:NM_019018.2,HGNC:HGNC:25629 OTU deubiquitinase with linear linkage specificity like OTX1 26.5934293105851 26.5402909448516 26.6465676763187 1.0040043544243 0.00576552635314071 1 1 0.399358 0.445246 0.286587 0.566379 GeneID:5013,Genbank:NM_001199770.1,HGNC:HGNC:8521,MIM:600036 orthodenticle homeobox 1 GO:0000978,GO:0001077,GO:0005634,GO:0009952,GO:0022037,GO:0030901,GO:0042472,GO:0045944,GO:0048852 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|anterior/posterior pattern specification|metencephalon development|midbrain development|inner ear morphogenesis|positive regulation of transcription from RNA polymerase II promoter|diencephalon morphogenesis hsa04550 Signaling pathways regulating pluripotency of stem cells OVCA2 60.9551310121949 56.0210103014473 65.8892517229426 1.17615250721818 0.234075141077405 0.720601301399224 1 55.1385 66.1043 57.0214 74.9747 GeneID:124641,Genbank:NM_080822.2,HGNC:HGNC:24203,MIM:607896 OVCA2, serine hydrolase domain containing GO:0005634,GO:0005737,GO:0016787,GO:0032526 nucleus|cytoplasm|hydrolase activity|response to retinoic acid OVCH1 1.72925684545285 1.51824048055703 1.94027321034868 1.27797488948313 0.353859489513337 1 1 0 0.00630924 0.00945575 0 GeneID:341350,Genbank:XM_024448968.1,HGNC:HGNC:23080 ovochymase 1 GO:0004252,GO:0005576,GO:0046872 serine-type endopeptidase activity|extracellular region|metal ion binding OVGP1 38.4953351363789 37.2542182030127 39.7364520697451 1.06662960562494 0.0930592774758699 0.844904070538885 1 0.60928 0.446829 0.54384 0.568166 GeneID:5016,Genbank:NM_002557.3,HGNC:HGNC:8524,MIM:603578 oviductal glycoprotein 1 GO:0004568,GO:0005576,GO:0005737,GO:0005829,GO:0005975,GO:0006032,GO:0007339,GO:0007565,GO:0008061,GO:0030133,GO:0035805,GO:0098595,GO:2000360 chitinase activity|extracellular region|cytoplasm|cytosol|carbohydrate metabolic process|chitin catabolic process|binding of sperm to zona pellucida|female pregnancy|chitin binding|transport vesicle|egg coat|perivitelline space|negative regulation of binding of sperm to zona pellucida OVOL1 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0079773 0 GeneID:5017,Genbank:NM_004561.3,HGNC:HGNC:8525,MIM:602313 ovo like transcriptional repressor 1 GO:0000978,GO:0000981,GO:0001078,GO:0001822,GO:0005634,GO:0006351,GO:0007283,GO:0007498,GO:0008544,GO:0043588,GO:0046872,GO:0051729,GO:1901994,GO:2000647 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|kidney development|nucleus|transcription, DNA-templated|spermatogenesis|mesoderm development|epidermis development|skin development|metal ion binding|germline cell cycle switching, mitotic to meiotic cell cycle|negative regulation of meiotic cell cycle phase transition|negative regulation of stem cell proliferation OVOL2 1.02566752891457 1.56626675524197 0.48506830258717 0.309697119576692 -1.69107012999473 0.789536483244536 1 0.0529668 0.0228528 0.0243834 0 GeneID:58495,Genbank:NM_001303462.1,HGNC:HGNC:15804,MIM:616441 ovo like zinc finger 2 GO:0000981,GO:0001228,GO:0001525,GO:0001755,GO:0001842,GO:0001947,GO:0003677,GO:0003682,GO:0005634,GO:0009913,GO:0009953,GO:0010719,GO:0010837,GO:0010944,GO:0044212,GO:0045617,GO:0045618,GO:0045746,GO:0045892,GO:0046872,GO:0048557,GO:0051726,GO:0060214,GO:0060347,GO:0060716,GO:2000647 RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|angiogenesis|neural crest cell migration|neural fold formation|heart looping|DNA binding|chromatin binding|nucleus|epidermal cell differentiation|dorsal/ventral pattern formation|negative regulation of epithelial to mesenchymal transition|regulation of keratinocyte proliferation|negative regulation of transcription by competitive promoter binding|transcription regulatory region DNA binding|negative regulation of keratinocyte differentiation|positive regulation of keratinocyte differentiation|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|metal ion binding|embryonic digestive tract morphogenesis|regulation of cell cycle|endocardium formation|heart trabecula formation|labyrinthine layer blood vessel development|negative regulation of stem cell proliferation OVOL3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:728361,Genbank:XM_017027190.1,HGNC:HGNC:14186,MIM:616442 ovo like zinc finger 3 GO:0000981,GO:0003676,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleic acid binding|nucleus|transcription, DNA-templated|metal ion binding OXA1L 1993.89793167767 1966.47686220092 2021.31900115441 1.02788852490851 0.0396838119227215 0.788406087459036 1 50.8993 53.7939 53.3237 55.4981 GeneID:5018,Genbank:NM_005015.3,HGNC:HGNC:8526,MIM:601066 OXA1L, mitochondrial inner membrane protein GO:0005739,GO:0005746,GO:0006461,GO:0009060,GO:0031966,GO:0032592,GO:0032780,GO:0032981,GO:0033615,GO:0042803,GO:0043234,GO:0051205,GO:0051262,GO:0051354,GO:0055114,GO:0097031,GO:0097177 mitochondrion|mitochondrial respiratory chain|protein complex assembly|aerobic respiration|mitochondrial membrane|integral component of mitochondrial membrane|negative regulation of ATPase activity|mitochondrial respiratory chain complex I assembly|mitochondrial proton-transporting ATP synthase complex assembly|protein homodimerization activity|protein complex|protein insertion into membrane|protein tetramerization|negative regulation of oxidoreductase activity|oxidation-reduction process|mitochondrial respiratory chain complex I biogenesis|mitochondrial ribosome binding hsa03060 Protein export OXCT1 1439.01308619988 1459.94123968088 1418.08493271888 0.971330142731531 -0.0419663622407875 0.808163425863177 1 16.3592 14.306 16.2604 13.8826 GeneID:5019,Genbank:NM_000436.3,HGNC:HGNC:8527,MIM:601424 3-oxoacid CoA-transferase 1 GO:0005654,GO:0005739,GO:0005759,GO:0007420,GO:0007507,GO:0007584,GO:0008260,GO:0009725,GO:0014823,GO:0035774,GO:0042182,GO:0042594,GO:0042803,GO:0045471,GO:0046950,GO:0046952,GO:0060612 nucleoplasm|mitochondrion|mitochondrial matrix|brain development|heart development|response to nutrient|3-oxoacid CoA-transferase activity|response to hormone|response to activity|positive regulation of insulin secretion involved in cellular response to glucose stimulus|ketone catabolic process|response to starvation|protein homodimerization activity|response to ethanol|cellular ketone body metabolic process|ketone body catabolic process|adipose tissue development hsa00072,hsa00280,hsa00650 Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism OXCT2 1.02273099320278 1.07619535328461 0.969266633120943 0.900641904987498 -0.150974490057726 1 1 0.0512681 0 0.0237671 0 GeneID:64064,Genbank:NM_022120.1,HGNC:HGNC:18606,MIM:610289 3-oxoacid CoA-transferase 2 GO:0005739,GO:0005759,GO:0008260,GO:0031514,GO:0046952 mitochondrion|mitochondrial matrix|3-oxoacid CoA-transferase activity|motile cilium|ketone body catabolic process hsa00072,hsa00280,hsa00650 Synthesis and degradation of ketone bodies|Valine, leucine and isoleucine degradation|Butanoate metabolism OXLD1 427.933228510153 427.488013979145 428.378443041161 1.00208293339906 0.00300191237776905 0.990751821720726 1 12.9451 12.195 12.1999 13.7497 GeneID:339229,Genbank:NM_001039842.2,HGNC:HGNC:27901 oxidoreductase like domain containing 1 OXNAD1 486.461978368808 497.979826620141 474.944130117476 0.953741707452264 -0.0683294867614323 0.713265495480043 1 0.598855 0.578955 0.598078 0.50486 GeneID:92106,Genbank:NM_001352982.1,HGNC:HGNC:25128 oxidoreductase NAD binding domain containing 1 GO:0005739,GO:0016491 mitochondrion|oxidoreductase activity OXR1 271.421319839575 286.925799513353 255.916840165798 0.891926904446555 -0.165002612223258 0.62998119106662 1 1.67651 1.27627 1.56069 1.09947 GeneID:55074,Genbank:NM_001198533.1,HGNC:HGNC:15822,MIM:605609 oxidation resistance 1 OXSM 347.629276751851 348.299377616754 346.959175886948 0.996152155829343 -0.00556197338228821 1 1 3.36583 3.18815 3.01618 3.4378 GeneID:54995,Genbank:XM_017006714.2,HGNC:HGNC:26063,MIM:610324 3-oxoacyl-ACP synthase, mitochondrial GO:0004315,GO:0005739,GO:0005829,GO:0006637,GO:0051790,GO:0051792 3-oxoacyl-[acyl-carrier-protein] synthase activity|mitochondrion|cytosol|acyl-CoA metabolic process|short-chain fatty acid biosynthetic process|medium-chain fatty acid biosynthetic process hsa00061,hsa00780 Fatty acid biosynthesis|Biotin metabolism OXSR1 2180.04717307824 2269.72687145632 2090.36747470015 0.920977541830357 -0.118762118467614 0.405243099411305 1 14.5449 14.207 14.7243 11.7598 GeneID:9943,Genbank:XM_011534331.2,HGNC:HGNC:8508,MIM:604046 oxidative stress responsive 1 OXTR 18.9139086466304 16.4987315322796 21.3290857609811 1.29277124845937 0.370467017677642 0.587849693812469 1 0.158323 0.129503 0.2458 0.140186 GeneID:5021,Genbank:NM_001354653.1,HGNC:HGNC:8529,MIM:167055 oxytocin receptor hsa04020,hsa04024,hsa04080,hsa04921 Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Oxytocin signaling pathway P2RX2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:22953,Genbank:NM_001282165.1,HGNC:HGNC:15459,MIM:600844 purinergic receptor P2X 2 hsa04020,hsa04080,hsa04742 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Taste transduction P2RX3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:5024,Genbank:XM_011545070.2,HGNC:HGNC:8534,MIM:600843 purinergic receptor P2X 3 hsa04020,hsa04080,hsa04742 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Taste transduction P2RX4 263.574452955991 236.382835528553 290.766070383429 1.23006422921222 0.29873364950488 0.148204620186188 1 4.18527 3.76307 5.1579 5.28138 GeneID:5025,Genbank:NM_001256796.1,HGNC:HGNC:8535,MIM:600846 purinergic receptor P2X 4 hsa04020,hsa04080 Calcium signaling pathway|Neuroactive ligand-receptor interaction P2RX5 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0.0364054 0 0 GeneID:5026,Genbank:NM_175080.2,HGNC:HGNC:8536,MIM:602836 purinergic receptor P2X 5 hsa04020,hsa04080 Calcium signaling pathway|Neuroactive ligand-receptor interaction P2RX6 32.1063959209335 23.9938813856949 40.218910456172 1.67621527378853 0.745207444074849 0.14341349514703 1 0.164473 0.18586 0.21898 0.390037 GeneID:9127,Genbank:XM_017029075.1,HGNC:HGNC:8538,MIM:608077 purinergic receptor P2X 6 hsa04020,hsa04080 Calcium signaling pathway|Neuroactive ligand-receptor interaction P2RX7 34.8177666736791 33.2954293677768 36.3401039795815 1.09144422131259 0.126238402713544 0.823886475218685 1 0.209209 0.212192 0.177796 0.261479 GeneID:5027,Genbank:XM_011538419.3,HGNC:HGNC:8537,MIM:602566 purinergic receptor P2X 7 hsa04020,hsa04080,hsa04621 Calcium signaling pathway|Neuroactive ligand-receptor interaction|NOD-like receptor signaling pathway P2RY1 17.832519273415 24.0320990052719 11.6329395415581 0.484058406176099 -1.04674696222862 0.220168287894291 1 0.229044 0.106049 0.099654 0.0661958 GeneID:5028,Genbank:NM_002563.4,HGNC:HGNC:8539,MIM:601167 purinergic receptor P2Y1 GO:0001934,GO:0004872,GO:0005524,GO:0005739,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007193,GO:0007200,GO:0007204,GO:0007568,GO:0008347,GO:0009612,GO:0009986,GO:0010469,GO:0010700,GO:0014069,GO:0016323,GO:0016324,GO:0019233,GO:0023019,GO:0030168,GO:0030425,GO:0031686,GO:0032962,GO:0042755,GO:0043270,GO:0043531,GO:0044297,GO:0045028,GO:0045031,GO:0045032,GO:0045211,GO:0045944,GO:0046887,GO:0046982,GO:0051100,GO:0060406,GO:0070374,GO:0070848,GO:0071407,GO:0072659,GO:0090075,GO:0097110,GO:0097746 positive regulation of protein phosphorylation|receptor activity|ATP binding|mitochondrion|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|aging|glial cell migration|response to mechanical stimulus|cell surface|regulation of receptor activity|negative regulation of norepinephrine secretion|postsynaptic density|basolateral plasma membrane|apical plasma membrane|sensory perception of pain|signal transduction involved in regulation of gene expression|platelet activation|dendrite|A1 adenosine receptor binding|positive regulation of inositol trisphosphate biosynthetic process|eating behavior|positive regulation of ion transport|ADP binding|cell body|G-protein coupled purinergic nucleotide receptor activity|ATP-activated adenosine receptor activity|ADP-activated adenosine receptor activity|postsynaptic membrane|positive regulation of transcription from RNA polymerase II promoter|positive regulation of hormone secretion|protein heterodimerization activity|negative regulation of binding|positive regulation of penile erection|positive regulation of ERK1 and ERK2 cascade|response to growth factor|cellular response to organic cyclic compound|protein localization to plasma membrane|relaxation of muscle|scaffold protein binding|regulation of blood vessel diameter hsa04015,hsa04080,hsa04611,hsa04742 Rap1 signaling pathway|Neuroactive ligand-receptor interaction|Platelet activation|Taste transduction P2RY4 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0390311 0 0 0 GeneID:5030,Genbank:NM_002565.3,HGNC:HGNC:8542,MIM:300038 pyrimidinergic receptor P2Y4 GO:0005524,GO:0005886,GO:0005887,GO:0007186,GO:0007200,GO:0007204,GO:0015065,GO:0016323,GO:0016324,GO:0030321,GO:0045028,GO:0045030,GO:0071380 ATP binding|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|uridine nucleotide receptor activity|basolateral plasma membrane|apical plasma membrane|transepithelial chloride transport|G-protein coupled purinergic nucleotide receptor activity|UTP-activated nucleotide receptor activity|cellular response to prostaglandin E stimulus hsa04080,hsa04742 Neuroactive ligand-receptor interaction|Taste transduction P2RY6 6.46736923900861 4.20872886376855 8.72600961424868 2.07331236976746 1.05193749240702 0.377325998844898 1 0.0257225 0.00574711 0.0664167 0.0282035 GeneID:5031,Genbank:XM_011545079.2,HGNC:HGNC:8543,MIM:602451 pyrimidinergic receptor P2Y6 GO:0004930,GO:0005886,GO:0005887,GO:0007186,GO:0007200,GO:0014911,GO:0016323,GO:0016324,GO:0030321,GO:0045028,GO:0045029,GO:0071380,GO:0071407 G-protein coupled receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of smooth muscle cell migration|basolateral plasma membrane|apical plasma membrane|transepithelial chloride transport|G-protein coupled purinergic nucleotide receptor activity|UDP-activated nucleotide receptor activity|cellular response to prostaglandin E stimulus|cellular response to organic cyclic compound hsa04080 Neuroactive ligand-receptor interaction P3H1 1468.01330802681 1385.6868113068 1550.33980474681 1.11882410375598 0.16198324043785 0.28050807440954 1 11.0577 12.6821 13.1943 13.3112 GeneID:64175,Genbank:NM_022356.3,HGNC:HGNC:19316,MIM:610339 prolyl 3-hydroxylase 1 P3H2 832.941712776221 758.973110451895 906.910315100547 1.19491758352357 0.256911115325508 0.449321526770818 1 6.60928 7.91473 10.8727 6.82283 GeneID:55214,Genbank:NM_001134418.1,HGNC:HGNC:19317,MIM:610341 prolyl 3-hydroxylase 2 GO:0005506,GO:0005604,GO:0005783,GO:0005788,GO:0005794,GO:0008285,GO:0016529,GO:0019511,GO:0019797,GO:0031418,GO:0032963 iron ion binding|basement membrane|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|negative regulation of cell proliferation|sarcoplasmic reticulum|peptidyl-proline hydroxylation|procollagen-proline 3-dioxygenase activity|L-ascorbic acid binding|collagen metabolic process P3H3 1597.29277734863 1514.46667781455 1680.11887688272 1.10937989029063 0.149753479105801 0.306785416929162 1 23.0351 23.6427 25.5431 27.9801 GeneID:10536,Genbank:NM_014262.4,HGNC:HGNC:19318,MIM:610342 prolyl 3-hydroxylase 3 GO:0005506,GO:0005783,GO:0008285,GO:0017185,GO:0019797,GO:0031418,GO:0032963,GO:0032964,GO:1902494 iron ion binding|endoplasmic reticulum|negative regulation of cell proliferation|peptidyl-lysine hydroxylation|procollagen-proline 3-dioxygenase activity|L-ascorbic acid binding|collagen metabolic process|collagen biosynthetic process|catalytic complex P3H4 1362.32419739242 1399.71658551994 1324.93180926491 0.946571486664748 -0.0792166300970844 0.5874680716406 1 16.4384 18.6656 16.8852 16.8148 GeneID:10609,Genbank:XM_024450538.1,HGNC:HGNC:16946,MIM:617419 prolyl 3-hydroxylase family member 4 (non-enzymatic) GO:0000794,GO:0000795,GO:0005730,GO:0005783,GO:0007130,GO:0017185,GO:0030199,GO:0032964,GO:0046849,GO:1902494 condensed nuclear chromosome|synaptonemal complex|nucleolus|endoplasmic reticulum|synaptonemal complex assembly|peptidyl-lysine hydroxylation|collagen fibril organization|collagen biosynthetic process|bone remodeling|catalytic complex P4HA1 1552.90243706531 1536.60308379433 1569.2017903363 1.02121478661976 0.0302863324273552 0.81270885394004 1 17.091 15.957 16.7203 17.0615 GeneID:5033,Genbank:NM_001142596.1,HGNC:HGNC:8546,MIM:176710 prolyl 4-hydroxylase subunit alpha 1 GO:0004656,GO:0005506,GO:0005739,GO:0005783,GO:0005788,GO:0016020,GO:0016222,GO:0016702,GO:0018401,GO:0030199,GO:0031418,GO:0042802,GO:0043231 procollagen-proline 4-dioxygenase activity|iron ion binding|mitochondrion|endoplasmic reticulum|endoplasmic reticulum lumen|membrane|procollagen-proline 4-dioxygenase complex|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|collagen fibril organization|L-ascorbic acid binding|identical protein binding|intracellular membrane-bounded organelle hsa00330 Arginine and proline metabolism P4HA2 1368.52466367111 1297.72491598387 1439.32441135836 1.10911364467957 0.149407197975365 0.321244165998329 1 7.64105 8.68045 9.43919 9.0935 GeneID:8974,Genbank:XM_017010012.2,HGNC:HGNC:8547,MIM:600608 prolyl 4-hydroxylase subunit alpha 2 GO:0004656,GO:0005506,GO:0005654,GO:0005783,GO:0005788,GO:0005829,GO:0009055,GO:0016702,GO:0031418,GO:0043231 procollagen-proline 4-dioxygenase activity|iron ion binding|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum lumen|cytosol|electron transfer activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|L-ascorbic acid binding|intracellular membrane-bounded organelle hsa00330 Arginine and proline metabolism P4HA3 4.71953734161018 3.6226049124413 5.81646977077905 1.60560422992948 0.683116322566929 0.673000122005313 1 0.0493573 0.0297552 0.062346 0.0726684 GeneID:283208,Genbank:NM_001288748.1,HGNC:HGNC:30135,MIM:608987 prolyl 4-hydroxylase subunit alpha 3 GO:0004656,GO:0005506,GO:0005788,GO:0016702,GO:0031418 procollagen-proline 4-dioxygenase activity|iron ion binding|endoplasmic reticulum lumen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|L-ascorbic acid binding hsa00330 Arginine and proline metabolism P4HB 26921.2359156388 24798.33131027 29044.1405210075 1.17121350455461 0.228004093674515 0.0807477671430941 0.951623427935096 292.106 314.199 353.906 361.994 GeneID:5034,Genbank:NM_000918.3,HGNC:HGNC:8548,MIM:176790 prolyl 4-hydroxylase subunit beta GO:0003723,GO:0003756,GO:0004656,GO:0005178,GO:0005576,GO:0005783,GO:0005788,GO:0005793,GO:0005925,GO:0006457,GO:0009897,GO:0015037,GO:0016222,GO:0018401,GO:0019899,GO:0031012,GO:0034378,GO:0034379,GO:0034599,GO:0034663,GO:0034976,GO:0035722,GO:0038155,GO:0042470,GO:0043687,GO:0044267,GO:0045454,GO:0046598,GO:0046982,GO:0070062,GO:0071456,GO:1902175 RNA binding|protein disulfide isomerase activity|procollagen-proline 4-dioxygenase activity|integrin binding|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|focal adhesion|protein folding|external side of plasma membrane|peptide disulfide oxidoreductase activity|procollagen-proline 4-dioxygenase complex|peptidyl-proline hydroxylation to 4-hydroxy-L-proline|enzyme binding|extracellular matrix|chylomicron assembly|very-low-density lipoprotein particle assembly|cellular response to oxidative stress|endoplasmic reticulum chaperone complex|response to endoplasmic reticulum stress|interleukin-12-mediated signaling pathway|interleukin-23-mediated signaling pathway|melanosome|post-translational protein modification|cellular protein metabolic process|cell redox homeostasis|positive regulation of viral entry into host cell|protein heterodimerization activity|extracellular exosome|cellular response to hypoxia|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway hsa04141 Protein processing in endoplasmic reticulum P4HTM 889.233974128887 831.069407467711 947.398540790064 1.13997523224542 0.189002479912052 0.231081061359784 1 14.9159 14.4261 16.5381 18.231 GeneID:54681,Genbank:NM_177938.2,HGNC:HGNC:28858,MIM:614584 prolyl 4-hydroxylase, transmembrane GO:0005506,GO:0005509,GO:0005789,GO:0016021,GO:0016706,GO:0031418,GO:0045646 iron ion binding|calcium ion binding|endoplasmic reticulum membrane|integral component of membrane|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|L-ascorbic acid binding|regulation of erythrocyte differentiation PA2G4 6158.19878805763 6662.88975791058 5653.50781820468 0.848506882691928 -0.237001732602935 0.0706855529838835 0.923837754446726 85.8028 91.2326 74.499 76.1294 GeneID:5036,Genbank:NM_006191.2,HGNC:HGNC:8550,MIM:602145 proliferation-associated 2G4 PAAF1 410.187164135801 419.1283911814 401.245937090201 0.957334185735322 -0.0629054669965692 0.73028030513762 1 5.33223 5.87858 4.92644 5.98963 GeneID:80227,Genbank:NM_001267806.1,HGNC:HGNC:25687 proteasomal ATPase associated factor 1 GO:0000502,GO:0016032 proteasome complex|viral process PABPC1 13878.9608111394 14781.9959960351 12975.9256262437 0.877819587403772 -0.188003632464919 0.148140513078712 1 187.214 185.457 176.994 152.559 GeneID:26986,Genbank:NM_002568.3,HGNC:HGNC:8554,MIM:604679 poly(A) binding protein cytoplasmic 1 GO:0000184,GO:0000289,GO:0000398,GO:0003723,GO:0003730,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0006378,GO:0006413,GO:0008022,GO:0008143,GO:0008266,GO:0008494,GO:0010494,GO:0016020,GO:0030529,GO:0031047,GO:0036464,GO:0043488,GO:0045070,GO:0048255,GO:0060213,GO:0070062,GO:0071013,GO:1900153,GO:2000623 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|cytosol|focal adhesion|mRNA polyadenylation|translational initiation|protein C-terminus binding|poly(A) binding|poly(U) RNA binding|translation activator activity|cytoplasmic stress granule|membrane|intracellular ribonucleoprotein complex|gene silencing by RNA|cytoplasmic ribonucleoprotein granule|regulation of mRNA stability|positive regulation of viral genome replication|mRNA stabilization|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|extracellular exosome|catalytic step 2 spliceosome|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay hsa03013,hsa03015,hsa03018 RNA transport|mRNA surveillance pathway|RNA degradation PABPC1L 109.405040487059 105.4015350387 113.408545935417 1.07596673894528 0.105633480961107 0.698164363506805 1 1.13998 0.956226 1.18183 0.893428 GeneID:80336,Genbank:NM_001124756.2,HGNC:HGNC:15797 poly(A) binding protein cytoplasmic 1 like GO:0001556,GO:0003723,GO:0006378,GO:0048096,GO:0051647,GO:0070062 oocyte maturation|RNA binding|mRNA polyadenylation|chromatin-mediated maintenance of transcription|nucleus localization|extracellular exosome hsa03013,hsa03015,hsa03018 RNA transport|mRNA surveillance pathway|RNA degradation PABPC3 6.45542886406492 6.61105959887042 6.29979812925943 0.952918066316605 -0.0695759210462981 1 1 0.0961959 0.144549 0.109831 0.118826 GeneID:5042,Genbank:NM_030979.2,HGNC:HGNC:8556,MIM:604680 poly(A) binding protein cytoplasmic 3 GO:0005737,GO:0005829,GO:0008143,GO:0016071,GO:0070062 cytoplasm|cytosol|poly(A) binding|mRNA metabolic process|extracellular exosome hsa03013,hsa03015,hsa03018 RNA transport|mRNA surveillance pathway|RNA degradation PABPC4 3655.0132871608 3768.36718558418 3541.65938873742 0.939839249817791 -0.089514075674551 0.510205585467449 1 48.8718 47.6569 47.8797 45.6131 GeneID:8761,Genbank:NM_003819.3,HGNC:HGNC:8557,MIM:603407 poly(A) binding protein cytoplasmic 4 GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0005829,GO:0006396,GO:0006401,GO:0006412,GO:0007596,GO:0008143,GO:0008266,GO:0010494,GO:0030529,GO:0043488,GO:0061515 RNA binding|mRNA binding|nucleus|cytoplasm|cytosol|RNA processing|RNA catabolic process|translation|blood coagulation|poly(A) binding|poly(U) RNA binding|cytoplasmic stress granule|intracellular ribonucleoprotein complex|regulation of mRNA stability|myeloid cell development hsa03013,hsa03015,hsa03018 RNA transport|mRNA surveillance pathway|RNA degradation PABPC4L 1.73425994482305 2.49838328447175 0.97013660517434 0.388305754046646 -1.3647350091371 0.673816326306802 1 0.0109337 0.0430975 0.021296 0 GeneID:132430,Genbank:NM_001114734.1,HGNC:HGNC:31955 poly(A) binding protein cytoplasmic 4 like GO:0003723 RNA binding hsa03013,hsa03015,hsa03018 RNA transport|mRNA surveillance pathway|RNA degradation PABPN1 407.281400156045 401.669134155422 412.893666156667 1.02794472128123 0.0397626843005403 0.858653882036081 1 7.61315 8.63959 8.29215 8.28717 GeneID:8106,Genbank:NM_004643.3,HGNC:HGNC:8565,MIM:602279 poly(A) binding protein nuclear 1 GO:0000165,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0006369,GO:0006396,GO:0006936,GO:0016607,GO:0016973,GO:0030529,GO:0031124,GO:0042405,GO:0046778,GO:0070063,GO:0071222,GO:1904247 MAPK cascade|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|cytoplasm|termination of RNA polymerase II transcription|RNA processing|muscle contraction|nuclear speck|poly(A)+ mRNA export from nucleus|intracellular ribonucleoprotein complex|mRNA 3'-end processing|nuclear inclusion body|modification by virus of host mRNA processing|RNA polymerase binding|cellular response to lipopolysaccharide|positive regulation of polynucleotide adenylyltransferase activity hsa03015,hsa05164 mRNA surveillance pathway|Influenza A PACRG 3.2395576909279 3.084507235799 3.39460814605679 1.10053499199442 0.138205017082497 1 1 0.00444772 0.00425111 0.00854587 0 GeneID:135138,Genbank:XM_017010277.2,HGNC:HGNC:19152,MIM:608427 parkin coregulated GO:0001664,GO:0003779,GO:0005634,GO:0005739,GO:0005829,GO:0007286,GO:0030544,GO:0031072,GO:0031625,GO:0031982,GO:0034620,GO:0043005,GO:0043014,GO:0044297,GO:0048487,GO:0051087,GO:0051879,GO:0060548,GO:0097225 G-protein coupled receptor binding|actin binding|nucleus|mitochondrion|cytosol|spermatid development|Hsp70 protein binding|heat shock protein binding|ubiquitin protein ligase binding|vesicle|cellular response to unfolded protein|neuron projection|alpha-tubulin binding|cell body|beta-tubulin binding|chaperone binding|Hsp90 protein binding|negative regulation of cell death|sperm midpiece PACRGL 256.976675887039 287.157139232525 226.796212541553 0.789798272638124 -0.34044388239315 0.107035959311843 1 1.36241 1.25964 1.03449 1.0853 GeneID:133015,Genbank:XM_011513798.2,HGNC:HGNC:28442 parkin coregulated like PACS1 1627.33835512996 1520.61607497593 1734.06063528398 1.14036716027182 0.189498398970086 0.191011956001986 1 9.39614 9.75266 11.7706 10.4212 GeneID:55690,Genbank:NM_018026.3,HGNC:HGNC:30032,MIM:607492 phosphofurin acidic cluster sorting protein 1 GO:0000042,GO:0005794,GO:0005829,GO:0030137,GO:0044325,GO:0050690,GO:0072659 protein targeting to Golgi|Golgi apparatus|cytosol|COPI-coated vesicle|ion channel binding|regulation of defense response to virus by virus|protein localization to plasma membrane PACS2 1201.81585158792 1084.96054329778 1318.67115987805 1.21540932343023 0.281442263981762 0.0616108450509675 0.886576185387508 5.44535 5.69259 7.25 6.77101 GeneID:23241,Genbank:XM_017021112.2,HGNC:HGNC:23794,MIM:610423 phosphofurin acidic cluster sorting protein 2 GO:0000045,GO:0005739,GO:0005783,GO:0006915,GO:0016032,GO:0034497,GO:0044325,GO:0072659 autophagosome assembly|mitochondrion|endoplasmic reticulum|apoptotic process|viral process|protein localization to phagophore assembly site|ion channel binding|protein localization to plasma membrane PACSIN1 3.33974336761458 4.25675513845349 2.42273159677566 0.569149861332135 -0.813119520151431 0.728723389322929 1 0.0555307 0.00694068 0.0147371 0.020685 GeneID:29993,Genbank:NM_020804.4,HGNC:HGNC:8570,MIM:606512 protein kinase C and casein kinase substrate in neurons 1 GO:0005543,GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0007015,GO:0008092,GO:0030054,GO:0030100,GO:0030137,GO:0030659,GO:0032587,GO:0042802,GO:0043209,GO:0043679,GO:0045202,GO:0045806,GO:0048471,GO:0048488,GO:0048812,GO:0072657,GO:0072659,GO:0097320,GO:1900006 phospholipid binding|cytoplasm|endosome|cytosol|plasma membrane|actin filament organization|cytoskeletal protein binding|cell junction|regulation of endocytosis|COPI-coated vesicle|cytoplasmic vesicle membrane|ruffle membrane|identical protein binding|myelin sheath|axon terminus|synapse|negative regulation of endocytosis|perinuclear region of cytoplasm|synaptic vesicle endocytosis|neuron projection morphogenesis|protein localization to membrane|protein localization to plasma membrane|plasma membrane tubulation|positive regulation of dendrite development PACSIN2 1914.41671538848 1874.83452703575 1953.9989037412 1.04222472733667 0.0596663889962696 0.675984139681023 1 11.7844 11.8617 12.8441 12.64 GeneID:11252,Genbank:NM_001349974.1,HGNC:HGNC:8571,MIM:604960 protein kinase C and casein kinase substrate in neurons 2 GO:0005215,GO:0005737,GO:0005769,GO:0005829,GO:0005856,GO:0005886,GO:0005901,GO:0005911,GO:0005925,GO:0008092,GO:0016607,GO:0019898,GO:0030036,GO:0030100,GO:0030659,GO:0032587,GO:0036010,GO:0042802,GO:0043231,GO:0045296,GO:0045806,GO:0048858,GO:0055038,GO:0061024,GO:0070062,GO:0070300,GO:0070836,GO:0072584,GO:0097320 transporter activity|cytoplasm|early endosome|cytosol|cytoskeleton|plasma membrane|caveola|cell-cell junction|focal adhesion|cytoskeletal protein binding|nuclear speck|extrinsic component of membrane|actin cytoskeleton organization|regulation of endocytosis|cytoplasmic vesicle membrane|ruffle membrane|protein localization to endosome|identical protein binding|intracellular membrane-bounded organelle|cadherin binding|negative regulation of endocytosis|cell projection morphogenesis|recycling endosome membrane|membrane organization|extracellular exosome|phosphatidic acid binding|caveola assembly|caveolin-mediated endocytosis|plasma membrane tubulation PACSIN3 1120.26280785099 1140.99136225434 1099.53425344765 0.963665711960537 -0.0533953211872191 0.736372954720665 1 18.1397 19.1353 17.1493 19.5882 GeneID:29763,Genbank:NM_001184974.1,HGNC:HGNC:8572,MIM:606513 protein kinase C and casein kinase substrate in neurons 3 GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0006897,GO:0008092,GO:0008289,GO:0019855,GO:0030100,GO:0045806,GO:0051044,GO:0051926,GO:0070062,GO:0097320 cytoplasm|endosome|cytosol|plasma membrane|endocytosis|cytoskeletal protein binding|lipid binding|calcium channel inhibitor activity|regulation of endocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis|negative regulation of calcium ion transport|extracellular exosome|plasma membrane tubulation PADI1 92.5866944684266 85.8379135808376 99.3354753560156 1.15724475598381 0.210694025119935 0.513995229673682 1 0.585396 0.618383 0.647 0.818848 GeneID:29943,Genbank:XM_017001103.2,HGNC:HGNC:18367,MIM:607934 peptidyl arginine deiminase 1 GO:0004668,GO:0005509,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006325,GO:0036414,GO:0070062 protein-arginine deiminase activity|calcium ion binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin organization|histone citrullination|extracellular exosome PADI2 9.06887473587884 10.8678147373239 7.26993473443377 0.668941724730203 -0.580047559812393 0.590321038971425 1 0.0892091 0.0719548 0.0502318 0.054703 GeneID:11240,Genbank:NM_007365.2,HGNC:HGNC:18341,MIM:607935 peptidyl arginine deiminase 2 GO:0004668,GO:0005509,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006325,GO:0010848,GO:0018101,GO:0021762,GO:0030331,GO:0030520,GO:0035327,GO:0035578,GO:0036413,GO:0043312,GO:0048096,GO:0070062,GO:0070100,GO:1901624,GO:1990830 protein-arginine deiminase activity|calcium ion binding|extracellular region|nucleus|cytoplasm|cytosol|chromatin organization|regulation of chromatin disassembly|protein citrullination|substantia nigra development|estrogen receptor binding|intracellular estrogen receptor signaling pathway|transcriptionally active chromatin|azurophil granule lumen|histone H3-R26 citrullination|neutrophil degranulation|chromatin-mediated maintenance of transcription|extracellular exosome|negative regulation of chemokine-mediated signaling pathway|negative regulation of lymphocyte chemotaxis|cellular response to leukemia inhibitory factor PADI3 74.0085179156301 85.9918010600004 62.0252347712598 0.721292425634648 -0.471343820882995 0.162812113711858 1 0.469438 0.551051 0.342526 0.420296 GeneID:51702,Genbank:XM_011541572.2,HGNC:HGNC:18337,MIM:606755 peptidyl arginine deiminase 3 GO:0004668,GO:0005509,GO:0005634,GO:0005737,GO:0005829,GO:0006325,GO:0018101,GO:0036414,GO:0042802 protein-arginine deiminase activity|calcium ion binding|nucleus|cytoplasm|cytosol|chromatin organization|protein citrullination|histone citrullination|identical protein binding PADI4 1.02316597922947 1.07619535328461 0.97013660517434 0.901450282435646 -0.149680169798226 1 1 0.0250238 0 0.0234441 0 GeneID:23569,Genbank:XM_011541151.1,HGNC:HGNC:18368,MIM:605347 peptidyl arginine deiminase 4 GO:0004668,GO:0005509,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006325,GO:0006334,GO:0006338,GO:0006351,GO:0006355,GO:0006464,GO:0016990,GO:0018101,GO:0019546,GO:0019827,GO:0034618,GO:0036413,GO:0036414,GO:0042803,GO:0043234,GO:0045087 protein-arginine deiminase activity|calcium ion binding|nucleus|nucleoplasm|cytoplasm|cytosol|chromatin organization|nucleosome assembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular protein modification process|arginine deiminase activity|protein citrullination|arginine deiminase pathway|stem cell population maintenance|arginine binding|histone H3-R26 citrullination|histone citrullination|protein homodimerization activity|protein complex|innate immune response PAEP 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:5047,Genbank:XM_017014782.2,HGNC:HGNC:8573,MIM:173310 progestagen associated endometrial protein PAF1 2983.32665545323 2946.58377679175 3020.06953411471 1.02493930697025 0.0355384813155779 0.812273643267933 1 33.9395 36.4277 35.6268 37.7013 GeneID:54623,Genbank:NM_001256826.1,HGNC:HGNC:25459,MIM:610506 PAF1 homolog, Paf1/RNA polymerase II complex component GO:0000122,GO:0000993,GO:0001711,GO:0006368,GO:0006378,GO:0016055,GO:0016570,GO:0016593,GO:0031442,GO:0032968,GO:0045638,GO:0045944,GO:0071222,GO:1902808 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II core binding|endodermal cell fate commitment|transcription elongation from RNA polymerase II promoter|mRNA polyadenylation|Wnt signaling pathway|histone modification|Cdc73/Paf1 complex|positive regulation of mRNA 3'-end processing|positive regulation of transcription elongation from RNA polymerase II promoter|negative regulation of myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|cellular response to lipopolysaccharide|positive regulation of cell cycle G1/S phase transition PAFAH1B1 2995.2619506112 2893.08752473754 3097.43637648486 1.0706334841238 0.0984646788415254 0.469879400061695 1 15.8081 16.2003 19.0989 15.855 GeneID:5048,Genbank:XM_017024701.1,HGNC:HGNC:8574,MIM:601545 platelet activating factor acetylhydrolase 1b regulatory subunit 1 GO:0000086,GO:0000132,GO:0000226,GO:0000235,GO:0000776,GO:0001667,GO:0001675,GO:0001764,GO:0001961,GO:0004623,GO:0005635,GO:0005813,GO:0005829,GO:0005871,GO:0005875,GO:0005938,GO:0007017,GO:0007062,GO:0007097,GO:0007268,GO:0007281,GO:0007405,GO:0007611,GO:0008017,GO:0008090,GO:0008201,GO:0008344,GO:0009306,GO:0010389,GO:0010977,GO:0016042,GO:0017145,GO:0019226,GO:0021540,GO:0021766,GO:0021819,GO:0021895,GO:0021987,GO:0030036,GO:0031023,GO:0031252,GO:0031514,GO:0031965,GO:0032420,GO:0034452,GO:0036035,GO:0040019,GO:0042249,GO:0042803,GO:0043025,GO:0043087,GO:0043274,GO:0043622,GO:0045505,GO:0045773,GO:0045931,GO:0046329,GO:0046469,GO:0047496,GO:0048471,GO:0048854,GO:0050885,GO:0051081,GO:0051219,GO:0051660,GO:0051661,GO:0060117,GO:0061003,GO:0070062,GO:0070507,GO:0070840,GO:0090102,GO:0090176,GO:0090724,GO:0097711,GO:1904115,GO:2000574 G2/M transition of mitotic cell cycle|establishment of mitotic spindle orientation|microtubule cytoskeleton organization|astral microtubule|kinetochore|ameboidal-type cell migration|acrosome assembly|neuron migration|positive regulation of cytokine-mediated signaling pathway|phospholipase A2 activity|nuclear envelope|centrosome|cytosol|kinesin complex|microtubule associated complex|cell cortex|microtubule-based process|sister chromatid cohesion|nuclear migration|chemical synaptic transmission|germ cell development|neuroblast proliferation|learning or memory|microtubule binding|retrograde axonal transport|heparin binding|adult locomotory behavior|protein secretion|regulation of G2/M transition of mitotic cell cycle|negative regulation of neuron projection development|lipid catabolic process|stem cell division|transmission of nerve impulse|corpus callosum morphogenesis|hippocampus development|layer formation in cerebral cortex|cerebral cortex neuron differentiation|cerebral cortex development|actin cytoskeleton organization|microtubule organizing center organization|cell leading edge|motile cilium|nuclear membrane|stereocilium|dynactin binding|osteoclast development|positive regulation of embryonic development|establishment of planar polarity of embryonic epithelium|protein homodimerization activity|neuronal cell body|regulation of GTPase activity|phospholipase binding|cortical microtubule organization|dynein intermediate chain binding|positive regulation of axon extension|positive regulation of mitotic cell cycle|negative regulation of JNK cascade|platelet activating factor metabolic process|vesicle transport along microtubule|perinuclear region of cytoplasm|brain morphogenesis|neuromuscular process controlling balance|nuclear envelope disassembly|phosphoprotein binding|establishment of centrosome localization|maintenance of centrosome location|auditory receptor cell development|positive regulation of dendritic spine morphogenesis|extracellular exosome|regulation of microtubule cytoskeleton organization|dynein complex binding|cochlea development|microtubule cytoskeleton organization involved in establishment of planar polarity|central region of growth cone|ciliary basal body-plasma membrane docking|axon cytoplasm|regulation of microtubule motor activity hsa00565 Ether lipid metabolism PAFAH1B2 2322.19267759784 2241.50464389664 2402.88071129904 1.07199452735545 0.10029754070492 0.456402258752387 1 14.99 14.1309 16.896 14.7695 GeneID:5049,Genbank:NM_001184748.1,HGNC:HGNC:8575,MIM:602508 platelet activating factor acetylhydrolase 1b catalytic subunit 2 GO:0001650,GO:0003847,GO:0005737,GO:0005829,GO:0005886,GO:0007283,GO:0007420,GO:0016042,GO:0016239,GO:0042803,GO:0046982,GO:0047179,GO:0070062 fibrillar center|1-alkyl-2-acetylglycerophosphocholine esterase activity|cytoplasm|cytosol|plasma membrane|spermatogenesis|brain development|lipid catabolic process|positive regulation of macroautophagy|protein homodimerization activity|protein heterodimerization activity|platelet-activating factor acetyltransferase activity|extracellular exosome hsa00565 Ether lipid metabolism PAFAH1B3 1426.77386235434 1419.62518255485 1433.92254215384 1.01007122145668 0.0144570228975919 0.938970999167138 1 44.8567 45.8483 45.0339 47.7872 GeneID:5050,Genbank:XM_017026848.1,HGNC:HGNC:8576,MIM:603074 platelet activating factor acetylhydrolase 1b catalytic subunit 3 GO:0003847,GO:0004623,GO:0005737,GO:0005829,GO:0006629,GO:0007283,GO:0007399,GO:0007420,GO:0016020,GO:0016042,GO:0042802,GO:0046982,GO:0047179,GO:0070062 1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipase A2 activity|cytoplasm|cytosol|lipid metabolic process|spermatogenesis|nervous system development|brain development|membrane|lipid catabolic process|identical protein binding|protein heterodimerization activity|platelet-activating factor acetyltransferase activity|extracellular exosome hsa00565 Ether lipid metabolism PAFAH2 447.332852006736 414.372772986736 480.292931026735 1.15908419263374 0.212985363483002 0.313826613899381 1 2.56557 3.57944 3.99391 3.19751 GeneID:5051,Genbank:XM_006710670.3,HGNC:HGNC:8579,MIM:602344 platelet activating factor acetylhydrolase 2 GO:0003847,GO:0005543,GO:0005789,GO:0006629,GO:0007596,GO:0016042,GO:0043066 1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding|endoplasmic reticulum membrane|lipid metabolic process|blood coagulation|lipid catabolic process|negative regulation of apoptotic process hsa00565 Ether lipid metabolism PAG1 84.1314126884511 70.8476138740071 97.4152115028951 1.37499636439605 0.459427804037501 0.152269334427851 1 0.257373 0.253052 0.394565 0.334801 GeneID:55824,Genbank:NM_018440.3,HGNC:HGNC:30043,MIM:605767 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 GO:0002250,GO:0005068,GO:0005070,GO:0005622,GO:0005886,GO:0005887,GO:0007165,GO:0007169,GO:0007173,GO:0035556,GO:0042169,GO:0045121,GO:0050852,GO:0050863,GO:0050868 adaptive immune response|transmembrane receptor protein tyrosine kinase adaptor activity|SH3/SH2 adaptor activity|intracellular|plasma membrane|integral component of plasma membrane|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|intracellular signal transduction|SH2 domain binding|membrane raft|T cell receptor signaling pathway|regulation of T cell activation|negative regulation of T cell activation PAGE2B 0.972203168832738 0.490071401957362 1.45433493570811 2.96759804775273 1.56929569647876 0.837430708298891 1 0 0.0309035 0 0 GeneID:389860,Genbank:XM_011530785.2,HGNC:HGNC:31805 PAGE family member 2B PAGE5 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:90737,Genbank:NM_130467.4,HGNC:HGNC:29992,MIM:301009 PAGE family member 5 PAGR1 1157.59081770823 1090.07297972631 1225.10865569015 1.12387764716243 0.168484982676183 0.273934846060034 1 10.3101 11.8585 12.518 12.8735 GeneID:79447,Genbank:NM_024516.3,HGNC:HGNC:28707,MIM:612033 PAXIP1 associated glutamate rich protein 1 GO:0005634,GO:0006281,GO:0006310,GO:0006351,GO:0030331,GO:0033148,GO:0035097,GO:0044666,GO:0045944,GO:1902808 nucleus|DNA repair|DNA recombination|transcription, DNA-templated|estrogen receptor binding|positive regulation of intracellular estrogen receptor signaling pathway|histone methyltransferase complex|MLL3/4 complex|positive regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle G1/S phase transition PAH 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.00838828 0.00780966 GeneID:5053,Genbank:NM_001354304.1,HGNC:HGNC:8582,MIM:612349 phenylalanine hydroxylase hsa00360,hsa00400,hsa00790 Phenylalanine metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis|Folate biosynthesis PAICS 12330.2066495892 13403.8209008894 11256.592398289 0.839804745342581 -0.251874154698635 0.0542468159116745 0.849526737634191 152.894 148.703 131.767 123.352 GeneID:10606,Genbank:NM_006452.3,HGNC:HGNC:8587,MIM:172439 phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase GO:0004638,GO:0004639,GO:0005524,GO:0005737,GO:0005829,GO:0006189,GO:0009113,GO:0009168,GO:0016020,GO:0042802,GO:0045296,GO:0070062 phosphoribosylaminoimidazole carboxylase activity|phosphoribosylaminoimidazolesuccinocarboxamide synthase activity|ATP binding|cytoplasm|cytosol|'de novo' IMP biosynthetic process|purine nucleobase biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|membrane|identical protein binding|cadherin binding|extracellular exosome hsa00230 Purine metabolism PAIP1 2836.57852343938 2858.8961624584 2814.26088442036 0.984387233567919 -0.0227021471559825 0.888355013259121 1 34.3837 32.6604 33.9829 32.1214 GeneID:10605,Genbank:NM_183323.2,HGNC:HGNC:16945,MIM:605184 poly(A) binding protein interacting protein 1 GO:0000289,GO:0003723,GO:0005737,GO:0005829,GO:0006413,GO:0008494,GO:0048255 nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|cytoplasm|cytosol|translational initiation|translation activator activity|mRNA stabilization hsa03013 RNA transport PAIP2 1288.85909367007 1301.14357314075 1276.57461419938 0.981117411292232 -0.0275022993672245 0.865198282375121 1 15.4984 14.7387 16.4196 13.9321 GeneID:51247,Genbank:NM_016480.4,HGNC:HGNC:17970,MIM:605604 poly(A) binding protein interacting protein 2 GO:0003729,GO:0005737,GO:0007283,GO:0007613,GO:0030371,GO:0045947,GO:1900271 mRNA binding|cytoplasm|spermatogenesis|memory|translation repressor activity|negative regulation of translational initiation|regulation of long-term synaptic potentiation PAIP2B 49.8540879361776 53.6667058410304 46.0414700313249 0.857914964404697 -0.22109343843459 0.591305378084765 1 0.264292 0.33175 0.267081 0.236224 GeneID:400961,Genbank:XM_011532843.2,HGNC:HGNC:29200,MIM:611018 poly(A) binding protein interacting protein 2B GO:0000900,GO:0005737,GO:0045947 translation repressor activity, nucleic acid binding|cytoplasm|negative regulation of translational initiation PAK1 708.486379701107 697.300549044422 719.672210357793 1.03208324063996 0.0455593331792878 0.770155485298054 1 4.82779 4.4157 4.90976 4.54925 GeneID:5058,Genbank:NM_002576.4,HGNC:HGNC:8590,MIM:602590 p21 (RAC1) activated kinase 1 hsa04010,hsa04012,hsa04014,hsa04024,hsa04062,hsa04360,hsa04392,hsa04510,hsa04625,hsa04650,hsa04660,hsa04666,hsa04810,hsa05120,hsa05170,hsa05205,hsa05211 MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Axon guidance|Hippo signaling pathway - multiple species|Focal adhesion|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Epithelial cell signaling in Helicobacter pylori infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer|Renal cell carcinoma PAK1IP1 778.988480984946 845.068738714664 712.908223255228 0.84360974509547 -0.245352334132591 0.126561689315354 1 14.3826 14.1002 12.7704 11.4651 GeneID:55003,Genbank:XM_011514720.1,HGNC:HGNC:20882,MIM:607811 PAK1 interacting protein 1 GO:0005730,GO:0008283,GO:0009968,GO:0042273,GO:0060021,GO:1901796 nucleolus|cell proliferation|negative regulation of signal transduction|ribosomal large subunit biogenesis|palate development|regulation of signal transduction by p53 class mediator PAK2 3677.14768717837 3668.17312252252 3686.12225183421 1.00489320670322 0.0070421896169885 0.971557962924906 1 25.1803 25.8784 30.428 21.3424 GeneID:5062,Genbank:NM_002577.4,HGNC:HGNC:8591,MIM:605022 p21 (RAC1) activated kinase 2 hsa04010,hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05170,hsa05211 MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection|Renal cell carcinoma PAK3 121.152241666593 116.76922983309 125.535253500097 1.07507134952879 0.104432410694268 0.705790792694904 1 0.280172 0.260283 0.380285 0.239192 GeneID:5063,Genbank:NM_001128166.2,HGNC:HGNC:8592,MIM:300142 p21 (RAC1) activated kinase 3 GO:0004674,GO:0004708,GO:0005524,GO:0005737,GO:0007409,GO:0016358,GO:0017124,GO:0030833,GO:0042981,GO:0046872,GO:0060997 protein serine/threonine kinase activity|MAP kinase kinase activity|ATP binding|cytoplasm|axonogenesis|dendrite development|SH3 domain binding|regulation of actin filament polymerization|regulation of apoptotic process|metal ion binding|dendritic spine morphogenesis hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05170,hsa05211 ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection|Renal cell carcinoma PAK4 2632.80065707995 2500.40540595333 2765.19590820657 1.10589902806273 0.145219669150282 0.299802875356547 1 25.3248 25.1299 27.9742 29.1016 GeneID:10298,Genbank:NM_001014831.2,HGNC:HGNC:16059,MIM:605451 p21 (RAC1) activated kinase 4 GO:0004672,GO:0004674,GO:0005524,GO:0005794,GO:0005913,GO:0005925,GO:0006915,GO:0006928,GO:0007010,GO:0007049,GO:0007165,GO:0007266,GO:0007346,GO:0008283,GO:0016049,GO:0016477,GO:0023014,GO:0030036,GO:0031098,GO:0032147,GO:0042981,GO:0043408,GO:0045766,GO:0048365,GO:0060996,GO:0071407,GO:0098641,GO:2000352 protein kinase activity|protein serine/threonine kinase activity|ATP binding|Golgi apparatus|cell-cell adherens junction|focal adhesion|apoptotic process|movement of cell or subcellular component|cytoskeleton organization|cell cycle|signal transduction|Rho protein signal transduction|regulation of mitotic cell cycle|cell proliferation|cell growth|cell migration|signal transduction by protein phosphorylation|actin cytoskeleton organization|stress-activated protein kinase signaling cascade|activation of protein kinase activity|regulation of apoptotic process|regulation of MAPK cascade|positive regulation of angiogenesis|Rac GTPase binding|dendritic spine development|cellular response to organic cyclic compound|cadherin binding involved in cell-cell adhesion|negative regulation of endothelial cell apoptotic process hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05170,hsa05206,hsa05211 ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection|MicroRNAs in cancer|Renal cell carcinoma PAK5 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.011979 0 GeneID:57144,Genbank:XM_017027960.1,HGNC:HGNC:15916,MIM:608038 p21 (RAC1) activated kinase 5 GO:0004674,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0006915,GO:0007010,GO:0007165,GO:0007266,GO:0007346,GO:0007612,GO:0007613,GO:0007626,GO:0008283,GO:0016049,GO:0016477,GO:0023014,GO:0030036,GO:0031098,GO:0032147,GO:0042981,GO:0043408,GO:0048365,GO:2001237 protein serine/threonine kinase activity|ATP binding|nucleoplasm|cytoplasm|mitochondrion|apoptotic process|cytoskeleton organization|signal transduction|Rho protein signal transduction|regulation of mitotic cell cycle|learning|memory|locomotory behavior|cell proliferation|cell growth|cell migration|signal transduction by protein phosphorylation|actin cytoskeleton organization|stress-activated protein kinase signaling cascade|activation of protein kinase activity|regulation of apoptotic process|regulation of MAPK cascade|Rac GTPase binding|negative regulation of extrinsic apoptotic signaling pathway hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05170,hsa05211 ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection|Renal cell carcinoma PAK6 8.69583371310582 8.66739775606975 8.72426967014188 1.0065615904188 0.00943545191469458 1 1 0.485847 0.586331 0.456445 0.516665 GeneID:56924,Genbank:NM_001276718.1,HGNC:HGNC:16061,MIM:608110 p21 (RAC1) activated kinase 6 hsa04012,hsa04014,hsa04360,hsa04510,hsa04660,hsa04810,hsa05170,hsa05211 ErbB signaling pathway|Ras signaling pathway|Axon guidance|Focal adhesion|T cell receptor signaling pathway|Regulation of actin cytoskeleton|Human immunodeficiency virus 1 infection|Renal cell carcinoma PALB2 241.87637039368 235.114535076529 248.63820571083 1.05751950056979 0.0806842667645585 0.710391119021486 1 1.61461 1.60607 1.87308 1.48483 GeneID:79728,Genbank:NM_024675.3,HGNC:HGNC:26144,MIM:610355 partner and localizer of BRCA2 GO:0000724,GO:0000731,GO:0000732,GO:0001756,GO:0001833,GO:0003677,GO:0005654,GO:0007498,GO:0009887,GO:0035264,GO:0036342,GO:0043066,GO:0048568 double-strand break repair via homologous recombination|DNA synthesis involved in DNA repair|strand displacement|somitogenesis|inner cell mass cell proliferation|DNA binding|nucleoplasm|mesoderm development|animal organ morphogenesis|multicellular organism growth|post-anal tail morphogenesis|negative regulation of apoptotic process|embryonic organ development hsa03440,hsa03460 Homologous recombination|Fanconi anemia pathway PALD1 26.0571928507195 29.8169032793903 22.2974824220487 0.747813487306741 -0.419249603505296 0.467998470972841 1 0.230106 0.18023 0.198792 0.121589 GeneID:27143,Genbank:XM_011539638.2,HGNC:HGNC:23530,MIM:614656 phosphatase domain containing, paladin 1 GO:0004722,GO:0004725,GO:0005634,GO:0005829,GO:0008138 protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|nucleus|cytosol|protein tyrosine/serine/threonine phosphatase activity PALLD 5213.81676121339 5256.26109548599 5171.37242694079 0.983849990134983 -0.0234897335773361 0.873148925035872 1 17.9795 16.8747 19.3186 15.5621 GeneID:23022,Genbank:XM_005262861.4,HGNC:HGNC:17068,MIM:608092 palladin, cytoskeletal associated protein GO:0001726,GO:0002102,GO:0003334,GO:0003382,GO:0003779,GO:0005634,GO:0005829,GO:0005884,GO:0005886,GO:0005925,GO:0007010,GO:0015629,GO:0016477,GO:0030018,GO:0030027,GO:0030036,GO:0030424,GO:0030426,GO:0051371 ruffle|podosome|keratinocyte development|epithelial cell morphogenesis|actin binding|nucleus|cytosol|actin filament|plasma membrane|focal adhesion|cytoskeleton organization|actin cytoskeleton|cell migration|Z disc|lamellipodium|actin cytoskeleton organization|axon|growth cone|muscle alpha-actinin binding PALM 318.691201239362 296.728244553355 340.654157925368 1.14803414969186 0.199165557395413 0.400305998381001 1 2.86168 2.94298 3.07646 3.87894 GeneID:5064,Genbank:NM_002579.2,HGNC:HGNC:8594,MIM:608134 paralemmin GO:0005634,GO:0005886,GO:0005887,GO:0006928,GO:0007010,GO:0007193,GO:0007194,GO:0008360,GO:0014069,GO:0016323,GO:0016327,GO:0030424,GO:0031410,GO:0031527,GO:0031750,GO:0032591,GO:0043231,GO:0051491,GO:0060074,GO:0060160,GO:0071257,GO:0072659 nucleus|plasma membrane|integral component of plasma membrane|movement of cell or subcellular component|cytoskeleton organization|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|negative regulation of adenylate cyclase activity|regulation of cell shape|postsynaptic density|basolateral plasma membrane|apicolateral plasma membrane|axon|cytoplasmic vesicle|filopodium membrane|D3 dopamine receptor binding|dendritic spine membrane|intracellular membrane-bounded organelle|positive regulation of filopodium assembly|synapse maturation|negative regulation of dopamine receptor signaling pathway|cellular response to electrical stimulus|protein localization to plasma membrane PALM2 47.6770806865323 63.3622726756998 31.9918886973649 0.504904375212447 -0.985917915874357 0.0170801040816183 0.540551256438365 0.283729 0.331284 0.256326 0.12588 GeneID:114299,Genbank:NM_001037293.2,HGNC:HGNC:15845 paralemmin 2 GO:0005886,GO:0008360 plasma membrane|regulation of cell shape PALM3 58.2597367813031 48.6699392720869 67.8495342905194 1.39407476781941 0.479307938731183 0.208983095357058 1 0.503471 0.51031 0.772415 0.681283 GeneID:342979,Genbank:XM_011527965.2,HGNC:HGNC:33274 paralemmin 3 GO:0001960,GO:0005524,GO:0005737,GO:0005886,GO:0008063,GO:0032496 negative regulation of cytokine-mediated signaling pathway|ATP binding|cytoplasm|plasma membrane|Toll signaling pathway|response to lipopolysaccharide PAM 5026.81655364164 4890.54947011709 5163.08363716619 1.05572669670645 0.0782364025575574 0.543349755512402 1 24.7866 24.2394 28.9724 23.723 GeneID:5066,Genbank:NM_001319943.1,HGNC:HGNC:8596,MIM:170270 peptidylglycine alpha-amidating monooxygenase GO:0001519,GO:0001666,GO:0001676,GO:0004504,GO:0004598,GO:0005507,GO:0005509,GO:0005802,GO:0005886,GO:0006357,GO:0007417,GO:0007507,GO:0007595,GO:0008270,GO:0009268,GO:0009404,GO:0009986,GO:0016020,GO:0016021,GO:0018032,GO:0019901,GO:0022602,GO:0030667,GO:0031418,GO:0032355,GO:0032956,GO:0042476,GO:0042493,GO:0043005,GO:0043204,GO:0046688,GO:0048471,GO:0050708,GO:0051260,GO:0051384,GO:0060135,GO:0060173,GO:0070062 peptide amidation|response to hypoxia|long-chain fatty acid metabolic process|peptidylglycine monooxygenase activity|peptidylamidoglycolate lyase activity|copper ion binding|calcium ion binding|trans-Golgi network|plasma membrane|regulation of transcription from RNA polymerase II promoter|central nervous system development|heart development|lactation|zinc ion binding|response to pH|toxin metabolic process|cell surface|membrane|integral component of membrane|protein amidation|protein kinase binding|ovulation cycle process|secretory granule membrane|L-ascorbic acid binding|response to estradiol|regulation of actin cytoskeleton organization|odontogenesis|response to drug|neuron projection|perikaryon|response to copper ion|perinuclear region of cytoplasm|regulation of protein secretion|protein homooligomerization|response to glucocorticoid|maternal process involved in female pregnancy|limb development|extracellular exosome PAM16 4.75486163577313 5.6309167949557 3.87880647659057 0.688841021423952 -0.537757035133581 0.757542466328574 1 28.4033 35.6167 18.1256 27.1395 GeneID:51025,Genbank:NM_016069.10,HGNC:HGNC:29679,MIM:614336 presequence translocase associated motor 16 GO:0001405,GO:0001503,GO:0005759,GO:0030150,GO:0031314,GO:0032780,GO:0043234 presequence translocase-associated import motor|ossification|mitochondrial matrix|protein import into mitochondrial matrix|extrinsic component of mitochondrial inner membrane|negative regulation of ATPase activity|protein complex PAMR1 5.55950660105149 6.75513842292525 4.36387477917774 0.646008194942067 -0.630375628532728 0.680186902720127 1 0.06144 0.0440909 0.0690308 0.0214508 GeneID:25891,Genbank:NM_001282675.1,HGNC:HGNC:24554 peptidase domain containing associated with muscle regeneration 1 GO:0005509,GO:0005615 calcium ion binding|extracellular space PAN2 273.027806532333 218.913769847467 327.141843217199 1.49438677815992 0.579553595728003 0.00498368816634629 0.281051935465501 1.05591 1.15313 1.9875 1.54389 GeneID:9924,Genbank:NM_001166279.1,HGNC:HGNC:20074,MIM:617447 PAN2 poly(A) specific ribonuclease subunit GO:0000175,GO:0000289,GO:0000932,GO:0003676,GO:0004535,GO:0005634,GO:0005829,GO:0006397,GO:0031251,GO:0046872 3'-5'-exoribonuclease activity|nuclear-transcribed mRNA poly(A) tail shortening|P-body|nucleic acid binding|poly(A)-specific ribonuclease activity|nucleus|cytosol|mRNA processing|PAN complex|metal ion binding hsa03018 RNA degradation PAN3 167.344402342637 198.484658444421 136.204146240854 0.686220019765376 -0.543256879229458 0.0263709734169731 0.649651937068338 0.710254 0.70981 0.599347 0.39358 GeneID:255967,Genbank:XM_011535034.3,HGNC:HGNC:29991,MIM:617448 PAN3 poly(A) specific ribonuclease subunit hsa03018 RNA degradation PANK1 286.273506567722 278.835734054357 293.711279081087 1.05334877567676 0.0749832080884753 0.713242958687796 1 0.983592 0.942051 1.10973 0.90487 GeneID:53354,Genbank:NM_148977.2,HGNC:HGNC:8598,MIM:606160 pantothenate kinase 1 GO:0004594,GO:0005524,GO:0005634,GO:0005829,GO:0009108,GO:0015937,GO:0030118,GO:0055037,GO:0071944 pantothenate kinase activity|ATP binding|nucleus|cytosol|coenzyme biosynthetic process|coenzyme A biosynthetic process|clathrin coat|recycling endosome|cell periphery hsa00770 Pantothenate and CoA biosynthesis PANK2 1107.74446431756 1094.00132559537 1121.48760303976 1.02512453760459 0.0357991866775322 0.808839633767877 1 3.12324 3.1297 3.55037 3.01353 GeneID:80025,Genbank:XM_024452002.1,HGNC:HGNC:15894,MIM:606157 pantothenate kinase 2 hsa00770 Pantothenate and CoA biosynthesis PANK3 748.131275812889 740.656138134131 755.606413491646 1.02018517715276 0.0288310442678386 0.848807100351225 1 9.48899 8.38215 10.6775 8.17946 GeneID:79646,Genbank:NM_024594.3,HGNC:HGNC:19365,MIM:606161 pantothenate kinase 3 GO:0004594,GO:0005524,GO:0005737,GO:0015937 pantothenate kinase activity|ATP binding|cytoplasm|coenzyme A biosynthetic process hsa00770 Pantothenate and CoA biosynthesis PANK4 616.140337741444 614.404080876183 617.876594606705 1.00565184027679 0.00813092617431127 0.979495929301016 1 4.78154 5.05002 5.02095 5.1891 GeneID:55229,Genbank:NM_018216.2,HGNC:HGNC:19366,MIM:606162 pantothenate kinase 4 GO:0004594,GO:0005524,GO:0005737,GO:0015937 pantothenate kinase activity|ATP binding|cytoplasm|coenzyme A biosynthetic process hsa00770 Pantothenate and CoA biosynthesis PANO1 16.3327421667925 14.2502882763405 18.4151960572445 1.29226831767459 0.369905652375716 0.639982283582823 1 0.318655 0.50435 0.580787 0.679903 GeneID:101927423,Genbank:NM_001293167.1,HGNC:HGNC:51237 proapoptotic nucleolar protein 1 GO:0005730,GO:0006915,GO:0031647,GO:0032435,GO:0043065 nucleolus|apoptotic process|regulation of protein stability|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of apoptotic process PANX1 943.761573547941 944.349285556451 943.17386153943 0.998755307982969 -0.00179682948218519 0.997360815223511 1 6.078 5.97592 6.86823 5.26697 GeneID:24145,Genbank:NM_015368.3,HGNC:HGNC:8599,MIM:608420 pannexin 1 hsa04621 NOD-like receptor signaling pathway PANX2 436.202975270314 347.53197422265 524.873976317978 1.51028974381998 0.594825352114978 0.0011985831105784 0.11383325497048 5.33356 6.27858 9.31455 8.44366 GeneID:56666,Genbank:NM_052839.3,HGNC:HGNC:8600,MIM:608421 pannexin 2 PAOX 63.8861713285367 55.0790851171096 72.6932575399639 1.31979783951391 0.400316961199748 0.266967632686349 1 1.52915 1.17624 2.00582 1.70509 GeneID:196743,Genbank:NM_152911.3,HGNC:HGNC:20837,MIM:615853 polyamine oxidase GO:0005102,GO:0005782,GO:0006596,GO:0006598,GO:0009446,GO:0009447,GO:0046203,GO:0046208,GO:0046592,GO:0052899,GO:0052901,GO:0052902,GO:0052903,GO:0052904,GO:1901307 receptor binding|peroxisomal matrix|polyamine biosynthetic process|polyamine catabolic process|putrescine biosynthetic process|putrescine catabolic process|spermidine catabolic process|spermine catabolic process|polyamine oxidase activity|N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity|spermine:oxygen oxidoreductase (spermidine-forming) activity|spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity|N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity|N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity|positive regulation of spermidine biosynthetic process hsa04146 Peroxisome PAPD4 386.325970820871 415.456742993419 357.195198648322 0.859765077044327 -0.217985584471021 0.258327815773983 1 2.51867 2.22041 2.39599 1.95166 GeneID:167153,Genbank:NM_001349553.1,HGNC:HGNC:26776,MIM:614121 poly(A) RNA polymerase D4, non-canonical GO:0002244,GO:0004652,GO:0005524,GO:0005829,GO:0006397,GO:0021766,GO:0030182,GO:0031380,GO:0043631,GO:0046872,GO:0060041,GO:0071044,GO:1990603 hematopoietic progenitor cell differentiation|polynucleotide adenylyltransferase activity|ATP binding|cytosol|mRNA processing|hippocampus development|neuron differentiation|nuclear RNA-directed RNA polymerase complex|RNA polyadenylation|metal ion binding|retina development in camera-type eye|histone mRNA catabolic process|dark adaptation PAPD5 309.796460768297 334.106924270207 285.485997266387 0.854474949568846 -0.22688989750034 0.279712938266249 1 1.85478 1.82717 1.85833 1.29583 GeneID:64282,Genbank:NM_001040284.2,HGNC:HGNC:30758,MIM:605540 poly(A) RNA polymerase D5, non-canonical GO:0003677,GO:0003887,GO:0004652,GO:0005730,GO:0005737,GO:0006364,GO:0006397,GO:0007049,GO:0032211,GO:0043630,GO:0046872,GO:0051301,GO:0071044 DNA binding|DNA-directed DNA polymerase activity|polynucleotide adenylyltransferase activity|nucleolus|cytoplasm|rRNA processing|mRNA processing|cell cycle|negative regulation of telomere maintenance via telomerase|ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process|metal ion binding|cell division|histone mRNA catabolic process hsa03018 RNA degradation PAPD7 1120.69592767687 1079.64619311541 1161.74566223834 1.07604293855381 0.105735648528974 0.489768206235175 1 6.21755 6.62738 7.63063 6.17691 GeneID:11044,Genbank:XM_005248234.4,HGNC:HGNC:16705,MIM:605198 poly(A) RNA polymerase D7, non-canonical hsa03018 RNA degradation PAPLN 34.3941248671095 39.2243124659501 29.5639372682689 0.753714607335253 -0.407909741849092 0.397152225963498 1 0.251817 0.292414 0.202681 0.189338 GeneID:89932,Genbank:XM_011537292.3,HGNC:HGNC:19262,MIM:617785 papilin, proteoglycan like sulfated glycoprotein GO:0004867,GO:0005576,GO:0008233 serine-type endopeptidase inhibitor activity|extracellular region|peptidase activity PAPOLA 1576.74083339955 1660.17547832503 1493.30618847408 0.899486956632255 -0.15282573363117 0.416041215894726 1 6.98821 6.69328 7.4016 5.18731 GeneID:10914,Genbank:NM_032632.4,HGNC:HGNC:14981,MIM:605553 poly(A) polymerase alpha GO:0000287,GO:0000398,GO:0003723,GO:0004652,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006369,GO:0006378,GO:0030145,GO:0031124,GO:0031440,GO:0043631 magnesium ion binding|mRNA splicing, via spliceosome|RNA binding|polynucleotide adenylyltransferase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|termination of RNA polymerase II transcription|mRNA polyadenylation|manganese ion binding|mRNA 3'-end processing|regulation of mRNA 3'-end processing|RNA polyadenylation hsa03015 mRNA surveillance pathway PAPOLG 162.587148148858 164.747183949371 160.427112348344 0.973777569379546 -0.0383358258654497 0.905949693444855 1 0.931983 0.812881 0.961887 0.767634 GeneID:64895,Genbank:NM_022894.3,HGNC:HGNC:14982,MIM:616865 poly(A) polymerase gamma GO:0003723,GO:0004652,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006378,GO:0016020,GO:0016604,GO:0043631,GO:0046872 RNA binding|polynucleotide adenylyltransferase activity|ATP binding|nucleus|nucleoplasm|cytosol|mRNA polyadenylation|membrane|nuclear body|RNA polyadenylation|metal ion binding hsa03015 mRNA surveillance pathway PAPPA 374.466364945013 343.696629900398 405.236099989627 1.17905171228203 0.237626995176667 0.514956841005715 1 1.19239 1.08306 1.73501 1.00606 GeneID:5069,Genbank:XM_017014784.2,HGNC:HGNC:8602,MIM:176385 pappalysin 1 GO:0004222,GO:0005576,GO:0005615,GO:0007565,GO:0008237,GO:0008270,GO:0032354,GO:0044267,GO:0051384 metalloendopeptidase activity|extracellular region|extracellular space|female pregnancy|metallopeptidase activity|zinc ion binding|response to follicle-stimulating hormone|cellular protein metabolic process|response to glucocorticoid PAPPA2 12.9800689709206 12.3860552178809 13.5740827239602 1.09591653558626 0.132137927604097 0.910262853604867 1 0.0388698 0.0306333 0.0513618 0.0239228 GeneID:60676,Genbank:XM_017002024.1,HGNC:HGNC:14615 pappalysin 2 GO:0001558,GO:0004222,GO:0005576,GO:0005622,GO:0005829,GO:0006508,GO:0008237,GO:0008270,GO:0009651,GO:0016324,GO:0044267,GO:0060349,GO:0070062 regulation of cell growth|metalloendopeptidase activity|extracellular region|intracellular|cytosol|proteolysis|metallopeptidase activity|zinc ion binding|response to salt stress|apical plasma membrane|cellular protein metabolic process|bone morphogenesis|extracellular exosome PAPSS1 1744.57803464728 1681.47988832837 1807.67618096618 1.07505072972551 0.104404739625529 0.456704836842435 1 22.1967 20.6202 23.9895 22.2487 GeneID:9061,Genbank:NM_005443.4,HGNC:HGNC:8603,MIM:603262 3'-phosphoadenosine 5'-phosphosulfate synthase 1 GO:0000103,GO:0001501,GO:0004020,GO:0004781,GO:0005524,GO:0005829,GO:0016779,GO:0042803,GO:0050428 sulfate assimilation|skeletal system development|adenylylsulfate kinase activity|sulfate adenylyltransferase (ATP) activity|ATP binding|cytosol|nucleotidyltransferase activity|protein homodimerization activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process hsa00230,hsa00450,hsa00920 Purine metabolism|Selenocompound metabolism|Sulfur metabolism PAPSS2 195.601697295048 205.585789445248 185.617605144847 0.902871767770122 -0.14740699437836 0.535488376685379 1 2.14845 1.98322 1.98567 1.74445 GeneID:9060,Genbank:NM_001015880.1,HGNC:HGNC:8604,MIM:603005 3'-phosphoadenosine 5'-phosphosulfate synthase 2 GO:0000103,GO:0001501,GO:0004020,GO:0004781,GO:0005524,GO:0005829,GO:0007596,GO:0016779,GO:0050428,GO:0060348 sulfate assimilation|skeletal system development|adenylylsulfate kinase activity|sulfate adenylyltransferase (ATP) activity|ATP binding|cytosol|blood coagulation|nucleotidyltransferase activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|bone development hsa00230,hsa00450,hsa00920 Purine metabolism|Selenocompound metabolism|Sulfur metabolism PAQR3 884.786451796733 1056.64902084128 712.923882752189 0.674702638899506 -0.567676290365156 0.00591777403896116 0.306728378666673 9.36698 8.11546 6.23157 5.44214 GeneID:152559,Genbank:XM_005262769.5,HGNC:HGNC:30130,MIM:614577 progestin and adipoQ receptor family member 3 GO:0000139,GO:0000165,GO:0001933,GO:0004872,GO:0005794,GO:0010977,GO:0016021,GO:0033137,GO:0034067,GO:0043407 Golgi membrane|MAPK cascade|negative regulation of protein phosphorylation|receptor activity|Golgi apparatus|negative regulation of neuron projection development|integral component of membrane|negative regulation of peptidyl-serine phosphorylation|protein localization to Golgi apparatus|negative regulation of MAP kinase activity PAQR4 955.265280073681 833.711869576237 1076.81869057112 1.29159572973149 0.369154576239983 0.0171116063320586 0.540551256438365 16.5405 16.8045 21.8569 21.8676 GeneID:124222,Genbank:NM_152341.4,HGNC:HGNC:26386,MIM:614578 progestin and adipoQ receptor family member 4 GO:0004872,GO:0016021 receptor activity|integral component of membrane PAQR5 5.57797328652198 6.31309329565283 4.84285327739113 0.76711257866661 -0.382489776917169 0.878259940770915 1 0.0518251 0.0106662 0.00546579 0.0356658 GeneID:54852,Genbank:XM_017022364.1,HGNC:HGNC:29645,MIM:607781 progestin and adipoQ receptor family member 5 GO:0003707,GO:0005496,GO:0005886,GO:0007275,GO:0016021,GO:0048477,GO:0048545 steroid hormone receptor activity|steroid binding|plasma membrane|multicellular organism development|integral component of membrane|oogenesis|response to steroid hormone PAQR6 60.0387934611866 54.1665858980957 65.9110010242775 1.21682029486364 0.283116120514758 0.50011841872717 1 0.416754 0.793531 0.995974 0.845042 GeneID:79957,Genbank:NM_001272112.1,HGNC:HGNC:30132,MIM:614579 progestin and adipoQ receptor family member 6 GO:0003707,GO:0005496,GO:0005886,GO:0016021,GO:0048545 steroid hormone receptor activity|steroid binding|plasma membrane|integral component of membrane|response to steroid hormone PAQR7 122.487010161306 138.360780483683 106.61323983893 0.77054523302218 -0.376048445686102 0.175961744345959 1 1.96507 1.73574 1.44257 1.33729 GeneID:164091,Genbank:XM_011540861.1,HGNC:HGNC:23146,MIM:607779 progestin and adipoQ receptor family member 7 GO:0003707,GO:0005496,GO:0005886,GO:0007275,GO:0016021,GO:0048477,GO:0048545 steroid hormone receptor activity|steroid binding|plasma membrane|multicellular organism development|integral component of membrane|oogenesis|response to steroid hormone PAQR8 626.340201172877 526.182436869605 726.497965476149 1.38069596126825 0.465395663214916 0.0048584895286138 0.278092687125054 4.95963 4.81459 7.4615 6.2011 GeneID:85315,Genbank:NM_133367.4,HGNC:HGNC:15708,MIM:607780 progestin and adipoQ receptor family member 8 GO:0003707,GO:0005496,GO:0005794,GO:0005886,GO:0007275,GO:0016021,GO:0048477,GO:0048545 steroid hormone receptor activity|steroid binding|Golgi apparatus|plasma membrane|multicellular organism development|integral component of membrane|oogenesis|response to steroid hormone PAQR9 1.96885446103465 1.02816907859967 2.90953984346962 2.82982624553573 1.50071347270393 0.612176619732697 1 0.0306059 0.0276978 0.115491 0.0269215 GeneID:344838,Genbank:NM_198504.2,HGNC:HGNC:30131,MIM:614580 progestin and adipoQ receptor family member 9 GO:0003707,GO:0005496,GO:0005886,GO:0016021,GO:0048545 steroid hormone receptor activity|steroid binding|plasma membrane|integral component of membrane|response to steroid hormone PARD3 993.600191672846 937.893130437598 1049.30725290809 1.11879191653585 0.161941735244435 0.294223226015061 1 4.15563 4.41036 5.36973 4.3919 GeneID:56288,Genbank:NM_001184790.1,HGNC:HGNC:16051,MIM:606745 par-3 family cell polarity regulator GO:0005546,GO:0005547,GO:0005829,GO:0005856,GO:0005886,GO:0005911,GO:0005912,GO:0005923,GO:0005938,GO:0006461,GO:0006612,GO:0007049,GO:0007163,GO:0007179,GO:0007205,GO:0007409,GO:0008356,GO:0010801,GO:0012505,GO:0019903,GO:0022011,GO:0030054,GO:0031643,GO:0032266,GO:0033269,GO:0042802,GO:0043025,GO:0043234,GO:0044295,GO:0060341,GO:0070830,GO:0090162 phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytosol|cytoskeleton|plasma membrane|cell-cell junction|adherens junction|bicellular tight junction|cell cortex|protein complex assembly|protein targeting to membrane|cell cycle|establishment or maintenance of cell polarity|transforming growth factor beta receptor signaling pathway|protein kinase C-activating G-protein coupled receptor signaling pathway|axonogenesis|asymmetric cell division|negative regulation of peptidyl-threonine phosphorylation|endomembrane system|protein phosphatase binding|myelination in peripheral nervous system|cell junction|positive regulation of myelination|phosphatidylinositol-3-phosphate binding|internode region of axon|identical protein binding|neuronal cell body|protein complex|axonal growth cone|regulation of cellular localization|bicellular tight junction assembly|establishment of epithelial cell polarity hsa04015,hsa04062,hsa04080,hsa04144,hsa04360,hsa04390,hsa04520,hsa04530,hsa05165 Rap1 signaling pathway|Chemokine signaling pathway|Neuroactive ligand-receptor interaction|Endocytosis|Axon guidance|Hippo signaling pathway|Adherens junction|Tight junction|Human papillomavirus infection PARD3B 180.631854566384 178.065355696482 183.198353436285 1.02882648182588 0.0409996829915299 0.85827406334673 1 0.269125 0.235516 0.294215 0.236969 GeneID:117583,Genbank:NM_001302769.1,HGNC:HGNC:14446 par-3 family cell polarity regulator beta GO:0005654,GO:0005923,GO:0007049,GO:0012505,GO:0016020,GO:0016604,GO:0030054,GO:0043234,GO:0051301 nucleoplasm|bicellular tight junction|cell cycle|endomembrane system|membrane|nuclear body|cell junction|protein complex|cell division PARD6A 320.504041604343 310.516870392207 330.491212816479 1.06432611020149 0.0899402612580891 0.648742104461059 1 12.6924 11.0667 11.7246 13.4066 GeneID:50855,Genbank:NM_016948.2,HGNC:HGNC:15943,MIM:607484 par-6 family cell polarity regulator alpha GO:0001726,GO:0001933,GO:0005080,GO:0005634,GO:0005813,GO:0005829,GO:0005886,GO:0005923,GO:0005938,GO:0007098,GO:0007163,GO:0007179,GO:0008134,GO:0016032,GO:0017048,GO:0030742,GO:0034451,GO:0043234,GO:0045217,GO:0051301,GO:0060071,GO:0070830,GO:1904781 ruffle|negative regulation of protein phosphorylation|protein kinase C binding|nucleus|centrosome|cytosol|plasma membrane|bicellular tight junction|cell cortex|centrosome cycle|establishment or maintenance of cell polarity|transforming growth factor beta receptor signaling pathway|transcription factor binding|viral process|Rho GTPase binding|GTP-dependent protein binding|centriolar satellite|protein complex|cell-cell junction maintenance|cell division|Wnt signaling pathway, planar cell polarity pathway|bicellular tight junction assembly|positive regulation of protein localization to centrosome hsa04015,hsa04144,hsa04360,hsa04390,hsa04530,hsa05165 Rap1 signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Human papillomavirus infection PARD6B 40.1902003992866 56.6355432172436 23.7448575813296 0.419257170188139 -1.25409263773718 0.0360408600259601 0.738653561785664 0.776624 0.455025 0.245453 0.280607 GeneID:84612,Genbank:NM_032521.2,HGNC:HGNC:16245,MIM:608975 par-6 family cell polarity regulator beta GO:0005634,GO:0005829,GO:0005886,GO:0005923,GO:0005938,GO:0006461,GO:0007043,GO:0007049,GO:0007163,GO:0007409,GO:0016324,GO:0030334,GO:0043234,GO:0051301,GO:0070062,GO:0070830 nucleus|cytosol|plasma membrane|bicellular tight junction|cell cortex|protein complex assembly|cell-cell junction assembly|cell cycle|establishment or maintenance of cell polarity|axonogenesis|apical plasma membrane|regulation of cell migration|protein complex|cell division|extracellular exosome|bicellular tight junction assembly hsa04015,hsa04144,hsa04360,hsa04390,hsa04530,hsa05165 Rap1 signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Human papillomavirus infection PARD6G 82.2040581915746 67.9552117369479 96.4529046462013 1.41935993106117 0.505240484332442 0.116076870811047 1 0.953605 0.804982 1.47931 1.07602 GeneID:84552,Genbank:NM_032510.3,HGNC:HGNC:16076,MIM:608976 par-6 family cell polarity regulator gamma GO:0005829,GO:0005886,GO:0005923,GO:0007049,GO:0007163,GO:0043234,GO:0051301,GO:0070830 cytosol|plasma membrane|bicellular tight junction|cell cycle|establishment or maintenance of cell polarity|protein complex|cell division|bicellular tight junction assembly hsa04015,hsa04144,hsa04360,hsa04390,hsa04530,hsa05165 Rap1 signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Human papillomavirus infection PARG 535.100202312429 538.030394410843 532.170010214014 0.989107707933032 -0.015800464459057 0.944249681493384 1 3.94266 3.75652 4.29347 3.43085 GeneID:8505,Genbank:NM_001303486.2,HGNC:HGNC:8605,MIM:603501 poly(ADP-ribose) glycohydrolase GO:0004649,GO:0005634,GO:0005654,GO:0005737,GO:0005759,GO:0005829,GO:0005975,GO:0043231,GO:1990966 poly(ADP-ribose) glycohydrolase activity|nucleus|nucleoplasm|cytoplasm|mitochondrial matrix|cytosol|carbohydrate metabolic process|intracellular membrane-bounded organelle|ATP generation from poly-ADP-D-ribose PARK7 5999.75313684341 6128.68388216603 5870.82239152079 0.957925470524661 -0.0620146805617955 0.651834664069173 1 208.674 219.386 200.506 222.63 GeneID:11315,Genbank:NM_007262.4,HGNC:HGNC:16369,MIM:602533 Parkinsonism associated deglycase hsa05012 Parkinson disease PARL 1450.24854834769 1435.01727576766 1465.47982092772 1.02122799890598 0.0303049976256464 0.829657860509935 1 16.4765 16.1905 16.7467 17.6543 GeneID:55486,Genbank:XM_017006802.1,HGNC:HGNC:18253,MIM:607858 presenilin associated rhomboid like GO:0004175,GO:0004252,GO:0005634,GO:0005743,GO:0006508,GO:0006851,GO:0010821,GO:0016021,GO:0030162,GO:0033619,GO:1903214,GO:2000377 endopeptidase activity|serine-type endopeptidase activity|nucleus|mitochondrial inner membrane|proteolysis|mitochondrial calcium ion transmembrane transport|regulation of mitochondrion organization|integral component of membrane|regulation of proteolysis|membrane protein proteolysis|regulation of protein targeting to mitochondrion|regulation of reactive oxygen species metabolic process PARM1 367.526371515791 346.810563101521 388.242179930061 1.11946469120784 0.162809025177843 0.486360615044155 1 2.42192 2.56174 3.40899 2.35102 GeneID:25849,Genbank:NM_015393.3,HGNC:HGNC:24536,MIM:617688 prostate androgen-regulated mucin-like protein 1 GO:0000139,GO:0005634,GO:0005769,GO:0005770,GO:0005794,GO:0005829,GO:0005886,GO:0010008,GO:0016021,GO:0043231,GO:0051973 Golgi membrane|nucleus|early endosome|late endosome|Golgi apparatus|cytosol|plasma membrane|endosome membrane|integral component of membrane|intracellular membrane-bounded organelle|positive regulation of telomerase activity PARN 578.634768248037 546.611548272651 610.657988223422 1.11716993567583 0.159848654674823 0.342764711617129 1 3.06341 2.95536 3.48327 3.09642 GeneID:5073,Genbank:NM_001134477.2,HGNC:HGNC:8609,MIM:604212 poly(A)-specific ribonuclease GO:0000184,GO:0000289,GO:0003723,GO:0003730,GO:0004518,GO:0004535,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0007292,GO:0009451,GO:0019901,GO:0032212,GO:0043169,GO:0043488,GO:0046872,GO:0051973,GO:0070034,GO:0090503,GO:0090669,GO:0110008,GO:1904872 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|mRNA 3'-UTR binding|nuclease activity|poly(A)-specific ribonuclease activity|nucleus|nucleolus|cytoplasm|cytosol|female gamete generation|RNA modification|protein kinase binding|positive regulation of telomere maintenance via telomerase|cation binding|regulation of mRNA stability|metal ion binding|positive regulation of telomerase activity|telomerase RNA binding|RNA phosphodiester bond hydrolysis, exonucleolytic|telomerase RNA stabilization|ncRNA deadenylation|regulation of telomerase RNA localization to Cajal body hsa03018 RNA degradation PARP1 6997.46208026177 7088.46652955743 6906.4576309661 0.974323233687795 -0.0375276261964698 0.765286865716444 1 53.1822 56.1697 55.2182 52.0156 GeneID:142,Genbank:NM_001618.3,HGNC:HGNC:270,MIM:173870 poly(ADP-ribose) polymerase 1 hsa03410,hsa04064,hsa04210,hsa04217 Base excision repair|NF-kappa B signaling pathway|Apoptosis|Necroptosis PARP10 689.976286620878 492.782163298205 887.170409943551 1.80032979279464 0.848261210359357 0.227124413223474 1 5.58352 5.99882 15.0348 6.32067 GeneID:84875,Genbank:NM_032789.4,HGNC:HGNC:25895,MIM:609564 poly(ADP-ribose) polymerase family member 10 GO:0003950,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006471,GO:0010629,GO:0010847,GO:0032088,GO:0033159,GO:0034356,GO:0043231,GO:0045071,GO:0048147,GO:0070212,GO:0070213,GO:0070530,GO:1900045 NAD+ ADP-ribosyltransferase activity|nucleus|nucleolus|cytoplasm|cytosol|protein ADP-ribosylation|negative regulation of gene expression|regulation of chromatin assembly|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein import into nucleus, translocation|NAD biosynthesis via nicotinamide riboside salvage pathway|intracellular membrane-bounded organelle|negative regulation of viral genome replication|negative regulation of fibroblast proliferation|protein poly-ADP-ribosylation|protein auto-ADP-ribosylation|K63-linked polyubiquitin modification-dependent protein binding|negative regulation of protein K63-linked ubiquitination PARP11 55.9155838132765 55.6171827937519 56.2139848328011 1.01073053342638 0.0153984177083667 0.982399715880954 1 0.459329 0.411934 0.461281 0.455412 GeneID:57097,Genbank:XM_011520970.2,HGNC:HGNC:1186,MIM:616706 poly(ADP-ribose) polymerase family member 11 GO:0003950,GO:0005635,GO:0005643,GO:0006998,GO:0007283,GO:0015031,GO:0030154,GO:0051028 NAD+ ADP-ribosyltransferase activity|nuclear envelope|nuclear pore|nuclear envelope organization|spermatogenesis|protein transport|cell differentiation|mRNA transport PARP12 1209.34574970094 944.773747375217 1473.91775202665 1.56007483921046 0.641615239067012 0.462385601337674 1 8.02939 8.72051 20.0453 6.80507 GeneID:64761,Genbank:NM_022750.3,HGNC:HGNC:21919,MIM:612481 poly(ADP-ribose) polymerase family member 12 GO:0003723,GO:0003950,GO:0005634,GO:0046872 RNA binding|NAD+ ADP-ribosyltransferase activity|nucleus|metal ion binding PARP14 1004.41721758523 707.40873504104 1301.42570012942 1.83970827000591 0.879477010421362 0.432150159689348 1 2.9677 2.66794 8.63244 2.1837 GeneID:54625,Genbank:XM_011512929.2,HGNC:HGNC:29232,MIM:610028 poly(ADP-ribose) polymerase family member 14 GO:0003723,GO:0003950,GO:0005634,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0006471,GO:0010629,GO:0016020,GO:0019899,GO:0042531,GO:0042532,GO:0045087,GO:0060336,GO:0070212,GO:0070403,GO:1902216 RNA binding|NAD+ ADP-ribosyltransferase activity|nucleus|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|protein ADP-ribosylation|negative regulation of gene expression|membrane|enzyme binding|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|innate immune response|negative regulation of interferon-gamma-mediated signaling pathway|protein poly-ADP-ribosylation|NAD+ binding|positive regulation of interleukin-4-mediated signaling pathway PARP15 1.04924568023034 1.61429302992691 0.484198330533773 0.299944509179783 -1.73723247328634 0.787670862996782 1 0.00997785 0 0 0.00445891 GeneID:165631,Genbank:XM_011512475.3,HGNC:HGNC:26876,MIM:612066 poly(ADP-ribose) polymerase family member 15 GO:0000122,GO:0001191,GO:0003950,GO:0005634,GO:0006351,GO:0070212,GO:0070403 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II transcription factor binding|NAD+ ADP-ribosyltransferase activity|nucleus|transcription, DNA-templated|protein poly-ADP-ribosylation|NAD+ binding PARP16 317.975196594426 285.072392110856 350.878001077995 1.23083823894651 0.299641170267309 0.132146823074767 1 2.82722 2.84384 3.77916 3.5937 GeneID:54956,Genbank:XM_006720590.3,HGNC:HGNC:26040 poly(ADP-ribose) polymerase family member 16 GO:0003950,GO:0005635,GO:0005783,GO:0005789,GO:0005829,GO:0006471,GO:0006987,GO:0016020,GO:0016021,GO:0019900,GO:0030968,GO:0034356,GO:0043539,GO:0060548,GO:0070213,GO:0071782,GO:0071902,GO:1990830 NAD+ ADP-ribosyltransferase activity|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein ADP-ribosylation|activation of signaling protein activity involved in unfolded protein response|membrane|integral component of membrane|kinase binding|endoplasmic reticulum unfolded protein response|NAD biosynthesis via nicotinamide riboside salvage pathway|protein serine/threonine kinase activator activity|negative regulation of cell death|protein auto-ADP-ribosylation|endoplasmic reticulum tubular network|positive regulation of protein serine/threonine kinase activity|cellular response to leukemia inhibitory factor PARP2 843.39204626016 854.668252999963 832.115839520356 0.973612669710796 -0.0385801527909351 0.818685069977779 1 10.5578 10.3303 10.7305 10.2798 GeneID:10038,Genbank:XM_017020912.1,HGNC:HGNC:272,MIM:607725 poly(ADP-ribose) polymerase 2 hsa03410,hsa04210,hsa04217 Base excision repair|Apoptosis|Necroptosis PARP3 317.748638068499 311.76657053487 323.730705602128 1.03837529805306 0.0543279685342138 0.810783848974497 1 3.39989 3.79675 3.69455 3.54389 GeneID:10039,Genbank:XM_005264779.5,HGNC:HGNC:273,MIM:607726 poly(ADP-ribose) polymerase family member 3 GO:0000723,GO:0003824,GO:0003910,GO:0003950,GO:0005634,GO:0005737,GO:0005814,GO:0006273,GO:0006281,GO:0006302,GO:0006471,GO:0035861,GO:0051103,GO:0051106,GO:0060236,GO:1990166 telomere maintenance|catalytic activity|DNA ligase (ATP) activity|NAD+ ADP-ribosyltransferase activity|nucleus|cytoplasm|centriole|lagging strand elongation|DNA repair|double-strand break repair|protein ADP-ribosylation|site of double-strand break|DNA ligation involved in DNA repair|positive regulation of DNA ligation|regulation of mitotic spindle organization|protein localization to site of double-strand break hsa03410,hsa04210,hsa04217 Base excision repair|Apoptosis|Necroptosis PARP4 2722.11943686398 2878.44220060776 2565.79667312021 0.891383774382709 -0.165881394684663 0.231350583094282 1 15.2748 14.7936 14.3081 12.0416 GeneID:143,Genbank:XM_011534931.1,HGNC:HGNC:271,MIM:607519 poly(ADP-ribose) polymerase family member 4 GO:0003677,GO:0003950,GO:0005634,GO:0005737,GO:0005829,GO:0005876,GO:0006281,GO:0006464,GO:0006471,GO:0006954,GO:0006974,GO:0008219,GO:0016020,GO:0019899,GO:0030529,GO:0042493,GO:0051972,GO:0070062 DNA binding|NAD+ ADP-ribosyltransferase activity|nucleus|cytoplasm|cytosol|spindle microtubule|DNA repair|cellular protein modification process|protein ADP-ribosylation|inflammatory response|cellular response to DNA damage stimulus|cell death|membrane|enzyme binding|intracellular ribonucleoprotein complex|response to drug|regulation of telomerase activity|extracellular exosome hsa03410,hsa04210,hsa04217 Base excision repair|Apoptosis|Necroptosis PARP6 1581.29315906829 1553.10384932832 1609.48246880826 1.03630061151695 0.051442562711576 0.725824268899513 1 11.0608 10.6207 11.5894 10.8108 GeneID:56965,Genbank:NM_001323522.1,HGNC:HGNC:26921 poly(ADP-ribose) polymerase family member 6 GO:0003950 NAD+ ADP-ribosyltransferase activity PARP8 56.6974347336711 60.5659230880104 52.8289463793317 0.872255282934665 -0.197177664559359 0.622243063898655 1 0.212226 0.274318 0.242022 0.180869 GeneID:79668,Genbank:XM_024446206.1,HGNC:HGNC:26124 poly(ADP-ribose) polymerase family member 8 GO:0003950,GO:0005622 NAD+ ADP-ribosyltransferase activity|intracellular PARP9 1416.95766698057 1088.54289658894 1745.3724373722 1.60340253272655 0.681136658222456 0.398038180355261 1 4.97026 4.80563 11.6848 4.20507 GeneID:83666,Genbank:NM_001146103.1,HGNC:HGNC:24118,MIM:612065 poly(ADP-ribose) polymerase family member 9 GO:0000122,GO:0001191,GO:0002230,GO:0003950,GO:0004857,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006302,GO:0006471,GO:0010608,GO:0010629,GO:0016020,GO:0016477,GO:0019899,GO:0034356,GO:0035563,GO:0042393,GO:0042531,GO:0043086,GO:0043234,GO:0044389,GO:0045087,GO:0045893,GO:0051607,GO:0060330,GO:0060335,GO:0072570,GO:0090734,GO:0097677,GO:1900182,GO:2001034 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II transcription factor binding|positive regulation of defense response to virus by host|NAD+ ADP-ribosyltransferase activity|enzyme inhibitor activity|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|double-strand break repair|protein ADP-ribosylation|posttranscriptional regulation of gene expression|negative regulation of gene expression|membrane|cell migration|enzyme binding|NAD biosynthesis via nicotinamide riboside salvage pathway|positive regulation of chromatin binding|histone binding|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of catalytic activity|protein complex|ubiquitin-like protein ligase binding|innate immune response|positive regulation of transcription, DNA-templated|defense response to virus|regulation of response to interferon-gamma|positive regulation of interferon-gamma-mediated signaling pathway|ADP-D-ribose binding|site of DNA damage|STAT family protein binding|positive regulation of protein localization to nucleus|positive regulation of double-strand break repair via nonhomologous end joining PARPBP 301.257053011214 336.423011111047 266.091094911381 0.790942016815697 -0.338356158872732 0.0897882610822033 0.979717040875575 2.02399 2.19439 1.9718 1.3731 GeneID:55010,Genbank:NM_001319993.1,HGNC:HGNC:26074,MIM:613687 PARP1 binding protein GO:0000785,GO:0003677,GO:0005654,GO:0005737,GO:0006281,GO:2000042 chromatin|DNA binding|nucleoplasm|cytoplasm|DNA repair|negative regulation of double-strand break repair via homologous recombination PARS2 134.616065907488 132.575976209564 136.656155605412 1.03077615954642 0.0437310751177988 0.857558657723849 1 2.55813 1.98339 2.12059 2.5188 GeneID:25973,Genbank:NM_152268.3,HGNC:HGNC:30563,MIM:612036 prolyl-tRNA synthetase 2, mitochondrial GO:0004827,GO:0005524,GO:0005759,GO:0006433 proline-tRNA ligase activity|ATP binding|mitochondrial matrix|prolyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis PARVA 1343.68848096403 1399.13721922115 1288.23974270691 0.920738670238526 -0.119136355128636 0.420269459147226 1 5.98968 5.98691 6.17241 4.92767 GeneID:55742,Genbank:XM_005253015.3,HGNC:HGNC:14652,MIM:608120 parvin alpha GO:0002040,GO:0003148,GO:0003779,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0007163,GO:0008360,GO:0030018,GO:0031532,GO:0034113,GO:0034446,GO:0045296,GO:0060271,GO:0070252,GO:0071670 sprouting angiogenesis|outflow tract septum morphogenesis|actin binding|cytosol|cytoskeleton|plasma membrane|focal adhesion|establishment or maintenance of cell polarity|regulation of cell shape|Z disc|actin cytoskeleton reorganization|heterotypic cell-cell adhesion|substrate adhesion-dependent cell spreading|cadherin binding|cilium assembly|actin-mediated cell contraction|smooth muscle cell chemotaxis hsa04510 Focal adhesion PARVB 2.9257457331852 3.43049981370153 2.42099165266886 0.705725633040218 -0.502820683042255 0.887467825307479 1 0 0 0 0.0610872 GeneID:29780,Genbank:XM_024452236.1,HGNC:HGNC:14653,MIM:608121 parvin beta hsa04510 Focal adhesion PASD1 1.02316597922947 1.07619535328461 0.97013660517434 0.901450282435646 -0.149680169798226 1 1 0.0220011 0 0.0104125 0 GeneID:139135,Genbank:XM_011531102.2,HGNC:HGNC:20686,MIM:300993 PAS domain containing repressor 1 GO:0001223,GO:0005634,GO:0016607,GO:0042754,GO:0045892,GO:0048511,GO:1990512 transcription coactivator binding|nucleus|nuclear speck|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|rhythmic process|Cry-Per complex PASK 399.611043051293 405.23390413807 393.988181964515 0.972248812207669 -0.0406025277613341 0.816490118690722 1 1.86964 2.04784 1.89037 2.01317 GeneID:23178,Genbank:XM_011510832.2,HGNC:HGNC:17270,MIM:607505 PAS domain containing serine/threonine kinase GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0035091,GO:0043576,GO:0045719,GO:0045727,GO:0046777,GO:0070092,GO:2000505 protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|phosphatidylinositol binding|regulation of respiratory gaseous exchange|negative regulation of glycogen biosynthetic process|positive regulation of translation|protein autophosphorylation|regulation of glucagon secretion|regulation of energy homeostasis PATJ 282.744117335678 301.349592579072 264.138642092285 0.876518995203142 -0.190142738656194 0.362199699900559 1 0.857661 0.777669 0.827261 0.70259 GeneID:10207,Genbank:NM_001350145.1,HGNC:HGNC:28881,MIM:603199 PATJ, crumbs cell polarity complex component GO:0005813,GO:0005815,GO:0005829,GO:0005886,GO:0005923,GO:0016324,GO:0030054,GO:0035556,GO:0043234,GO:0048471,GO:0070062,GO:0070830 centrosome|microtubule organizing center|cytosol|plasma membrane|bicellular tight junction|apical plasma membrane|cell junction|intracellular signal transduction|protein complex|perinuclear region of cytoplasm|extracellular exosome|bicellular tight junction assembly hsa04390,hsa04530,hsa05165 Hippo signaling pathway|Tight junction|Human papillomavirus infection PATL1 1636.59048543074 1634.03799788702 1639.14297297446 1.00312414710921 0.00450016560632001 0.952711452682836 1 14.9713 12.6773 15.4895 12.4248 GeneID:219988,Genbank:NM_152716.2,HGNC:HGNC:26721,MIM:614660 PAT1 homolog 1, processing body mRNA decay factor GO:0000290,GO:0000932,GO:0003723,GO:0005829,GO:0008266,GO:0016605,GO:0016607,GO:0033962,GO:0034046,GO:0036464,GO:0043928 deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|RNA binding|cytosol|poly(U) RNA binding|PML body|nuclear speck|cytoplasmic mRNA processing body assembly|poly(G) binding|cytoplasmic ribonucleoprotein granule|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay hsa03018 RNA degradation PATL2 4.2407770964733 4.60274771635603 3.87880647659057 0.84271542035795 -0.246882570425283 0.950363610155825 1 0.00840587 0.0155664 0 0.014943 GeneID:197135,Genbank:XM_011521340.3,HGNC:HGNC:33630,MIM:614661 PAT1 homolog 2 GO:0000290,GO:0000932,GO:0003723,GO:0005634,GO:0005737,GO:0010607,GO:0017148,GO:0033962 deadenylation-dependent decapping of nuclear-transcribed mRNA|P-body|RNA binding|nucleus|cytoplasm|negative regulation of cytoplasmic mRNA processing body assembly|negative regulation of translation|cytoplasmic mRNA processing body assembly PATZ1 806.200032660164 804.058662431118 808.341402889211 1.00532640298302 0.0076639825109221 0.987060480311903 1 6.54462 7.44257 7.25603 7.0431 GeneID:23598,Genbank:NM_032050.1,HGNC:HGNC:13071,MIM:605165 POZ/BTB and AT hook containing zinc finger 1 GO:0000978,GO:0001077,GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0006355,GO:0007283,GO:0008584,GO:0030217,GO:0045892,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|chromatin binding|nucleus|nucleoplasm|regulation of transcription, DNA-templated|spermatogenesis|male gonad development|T cell differentiation|negative regulation of transcription, DNA-templated|metal ion binding PAWR 593.610794705694 670.548535690614 516.673053720773 0.770522976668108 -0.376090116952109 0.0462373859988736 0.79332376136203 2.55455 2.39039 2.11419 1.52732 GeneID:5074,Genbank:NM_002583.3,HGNC:HGNC:8614,MIM:601936 pro-apoptotic WT1 regulator PAX2 2.22139481106861 2.98845468642911 1.45433493570811 0.486651158644767 -1.03904010497772 0.699608453666305 1 0.0127694 0.0217417 0.0116921 0.0109687 GeneID:5076,Genbank:NM_001304569.1,HGNC:HGNC:8616,MIM:167409 paired box 2 PAX5 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00398785 0 0 GeneID:5079,Genbank:NM_001280551.1,HGNC:HGNC:8619,MIM:167414 paired box 5 hsa05202 Transcriptional misregulation in cancer PAX6 300.534046628396 321.922782806173 279.145310450618 0.867118841410764 -0.205698361919598 0.30846883536943 1 0.926271 0.854507 0.859904 0.718286 GeneID:5080,Genbank:NM_001127612.1,HGNC:HGNC:8620,MIM:607108 paired box 6 hsa04550,hsa04950 Signaling pathways regulating pluripotency of stem cells|Maturity onset diabetes of the young PAX7 400.685554848246 417.033835404624 384.337274291869 0.92159734214124 -0.117791538789842 0.513053044525466 1 2.09497 2.22954 2.27072 1.78679 GeneID:5081,Genbank:NM_001135254.1,HGNC:HGNC:8621,MIM:167410 paired box 7 GO:0000983,GO:0003700,GO:0005634,GO:0006338,GO:0006351,GO:0009653,GO:0010453,GO:0014813,GO:0021527,GO:0021904,GO:0031062,GO:0043066,GO:0043393,GO:0043403,GO:0043565,GO:0045944,GO:0048663,GO:0048706,GO:0051216,GO:0060415,GO:2000288 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|chromatin remodeling|transcription, DNA-templated|anatomical structure morphogenesis|regulation of cell fate commitment|skeletal muscle satellite cell commitment|spinal cord association neuron differentiation|dorsal/ventral neural tube patterning|positive regulation of histone methylation|negative regulation of apoptotic process|regulation of protein binding|skeletal muscle tissue regeneration|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|neuron fate commitment|embryonic skeletal system development|cartilage development|muscle tissue morphogenesis|positive regulation of myoblast proliferation hsa05202 Transcriptional misregulation in cancer PAX8 189.186867779036 179.161168359983 199.212567198089 1.11191821878398 0.153050682221879 0.559296065628682 1 1.3728 1.52409 1.9376 1.33927 GeneID:7849,Genbank:NM_013992.3,HGNC:HGNC:8622,MIM:167415 paired box 8 hsa04918,hsa05200,hsa05202,hsa05216 Thyroid hormone synthesis|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer PAX9 64.4266117298161 69.2333208440802 59.6199026155521 0.861144632218662 -0.215672531294238 0.560688464891317 1 0.966236 0.978702 1.08727 0.657454 GeneID:5083,Genbank:NM_006194.3,HGNC:HGNC:8623,MIM:167416 paired box 9 PAXBP1 212.259588388793 231.136128931077 193.383047846509 0.836663003489923 -0.257281453109043 0.26093914402985 1 1.57109 1.4981 1.38653 1.21195 GeneID:94104,Genbank:NM_016631.3,HGNC:HGNC:13579,MIM:617621 PAX3 and PAX7 binding protein 1 GO:0000978,GO:0003700,GO:0005634,GO:0005829,GO:0006351,GO:0007517,GO:0008134,GO:0014842,GO:0031062,GO:0045944,GO:2000288 RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|cytosol|transcription, DNA-templated|muscle organ development|transcription factor binding|regulation of skeletal muscle satellite cell proliferation|positive regulation of histone methylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of myoblast proliferation PAXIP1 736.32541412042 767.015149636206 705.635678604634 0.919976194654455 -0.120331564476737 0.449423706653244 1 4.05781 4.50477 4.28105 3.79024 GeneID:22976,Genbank:XM_024446693.1,HGNC:HGNC:8624,MIM:608254 PAX interacting protein 1 GO:0000416,GO:0001570,GO:0005634,GO:0005654,GO:0005694,GO:0006303,GO:0006310,GO:0006351,GO:0010212,GO:0016363,GO:0030330,GO:0031398,GO:0035066,GO:0035097,GO:0043542,GO:0044666,GO:0045830,GO:0048304,GO:0051568,GO:0051571,GO:0060261,GO:0060612,GO:0060717,GO:1902749,GO:2001022 positive regulation of histone H3-K36 methylation|vasculogenesis|nucleus|nucleoplasm|chromosome|double-strand break repair via nonhomologous end joining|DNA recombination|transcription, DNA-templated|response to ionizing radiation|nuclear matrix|DNA damage response, signal transduction by p53 class mediator|positive regulation of protein ubiquitination|positive regulation of histone acetylation|histone methyltransferase complex|endothelial cell migration|MLL3/4 complex|positive regulation of isotype switching|positive regulation of isotype switching to IgG isotypes|histone H3-K4 methylation|positive regulation of histone H3-K4 methylation|positive regulation of transcription initiation from RNA polymerase II promoter|adipose tissue development|chorion development|regulation of cell cycle G2/M phase transition|positive regulation of response to DNA damage stimulus PAXX 540.469225255147 541.586372739238 539.352077771055 0.995874536213157 -0.0059640969559512 0.970962325786794 1 23.4912 22.2897 22.5367 22.4143 GeneID:286257,Genbank:NM_183241.2,HGNC:HGNC:27849,MIM:616315 PAXX, non-homologous end joining factor GO:0005634,GO:0006303,GO:0006974,GO:0032947,GO:0035861,GO:0042802,GO:0042803,GO:0051103,GO:0070062,GO:0070419 nucleus|double-strand break repair via nonhomologous end joining|cellular response to DNA damage stimulus|protein complex scaffold activity|site of double-strand break|identical protein binding|protein homodimerization activity|DNA ligation involved in DNA repair|extracellular exosome|nonhomologous end joining complex PBDC1 477.210900574478 470.737741864377 483.684059284579 1.02750218703291 0.0391414646789002 0.804095844400677 1 10.0783 9.10968 10.9265 9.19636 GeneID:51260,Genbank:NM_016500.4,HGNC:HGNC:28790 polysaccharide biosynthesis domain containing 1 GO:0005737 cytoplasm PBK 1802.95370879013 1891.26256398057 1714.6448535997 0.906613860103517 -0.141439877905949 0.341964534301132 1 35.0888 28.7258 29.583 27.6479 GeneID:55872,Genbank:NM_001278945.1,HGNC:HGNC:18282,MIM:611210 PDZ binding kinase GO:0000278,GO:0004674,GO:0005524,GO:0005634,GO:0032435,GO:0032873,GO:0034644,GO:0050728 mitotic cell cycle|protein serine/threonine kinase activity|ATP binding|nucleus|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of stress-activated MAPK cascade|cellular response to UV|negative regulation of inflammatory response PBLD 116.782623517114 87.2120752373398 146.353171796889 1.67812967870105 0.746854205402341 0.00838210904529856 0.356525902221039 0.795417 0.937809 1.41746 1.2982 GeneID:64081,Genbank:XM_011540060.3,HGNC:HGNC:23301,MIM:612189 phenazine biosynthesis like protein domain containing GO:0005737,GO:0009058,GO:0010633,GO:0010719,GO:0016853,GO:0030277,GO:0030512,GO:0042802,GO:0050680,GO:0060392,GO:0060394,GO:0070062 cytoplasm|biosynthetic process|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|isomerase activity|maintenance of gastrointestinal epithelium|negative regulation of transforming growth factor beta receptor signaling pathway|identical protein binding|negative regulation of epithelial cell proliferation|negative regulation of SMAD protein import into nucleus|negative regulation of pathway-restricted SMAD protein phosphorylation|extracellular exosome PBRM1 908.000445780314 991.999847404192 824.001044156437 0.830646341642729 -0.267693733125678 0.317907453176742 1 3.55536 3.16897 3.37423 2.2826 GeneID:55193,Genbank:NM_018313.4,HGNC:HGNC:30064,MIM:606083 polybromo 1 GO:0000228,GO:0000278,GO:0003677,GO:0003682,GO:0005654,GO:0006338,GO:0006351,GO:0006355,GO:0008285,GO:0016569,GO:0016586 nuclear chromosome|mitotic cell cycle|DNA binding|chromatin binding|nucleoplasm|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of cell proliferation|covalent chromatin modification|RSC-type complex hsa05225 Hepatocellular carcinoma PBX1 1955.97826750389 1775.58238915843 2136.37414584934 1.20319629147815 0.266872025424126 0.05853981822845 0.878658544068731 7.58863 7.82089 10.1744 8.41098 GeneID:5087,Genbank:NM_001353131.1,HGNC:HGNC:8632,MIM:176310 PBX homeobox 1 GO:0003700,GO:0005634,GO:0005667,GO:0006351,GO:0007399,GO:0014036,GO:0043565,GO:0045893,GO:0045944 DNA binding transcription factor activity|nucleus|transcription factor complex|transcription, DNA-templated|nervous system development|neural crest cell fate specification|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter hsa04927,hsa04934,hsa05202 Cortisol synthesis and secretion|Cushing syndrome|Transcriptional misregulation in cancer PBX2 1297.51110989553 1285.52994886387 1309.49227092719 1.01864003408439 0.026644323545836 0.865124819987504 1 13.3892 13.6966 14.7335 13.6452 GeneID:5089,Genbank:NM_002586.4,HGNC:HGNC:8633,MIM:176311 PBX homeobox 2 GO:0000977,GO:0001228,GO:0003682,GO:0005634,GO:0005667,GO:0008134,GO:0009954,GO:0030326,GO:0045944 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|nucleus|transcription factor complex|transcription factor binding|proximal/distal pattern formation|embryonic limb morphogenesis|positive regulation of transcription from RNA polymerase II promoter PBX3 838.779286333224 853.648875575617 823.909697090831 0.965162282367287 -0.0511565573951357 0.774231488929823 1 9.53679 8.159 9.14385 8.04471 GeneID:5090,Genbank:NM_006195.5,HGNC:HGNC:8634,MIM:176312 PBX homeobox 3 GO:0000980,GO:0001205,GO:0002087,GO:0005634,GO:0005667,GO:0007387,GO:0007388,GO:0007585,GO:0008344,GO:0021516,GO:0048666 RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|regulation of respiratory gaseous exchange by neurological system process|nucleus|transcription factor complex|anterior compartment pattern formation|posterior compartment specification|respiratory gaseous exchange|adult locomotory behavior|dorsal spinal cord development|neuron development hsa05202 Transcriptional misregulation in cancer PBX4 31.8935666525042 34.2275458970066 29.5595874080019 0.863619831142701 -0.211531722806772 0.687795859967036 1 0.385711 0.452921 0.255062 0.476157 GeneID:80714,Genbank:NM_025245.2,HGNC:HGNC:13403,MIM:608127 PBX homeobox 4 GO:0001741,GO:0003700,GO:0005634,GO:0006366,GO:0043565,GO:0045893 XY body|DNA binding transcription factor activity|nucleus|transcription from RNA polymerase II promoter|sequence-specific DNA binding|positive regulation of transcription, DNA-templated PBXIP1 1945.85482748427 1613.04644784628 2278.66320712226 1.41264574877228 0.498399724294776 0.000454905818384548 0.0592339153434709 15.8483 17.2703 23.5819 23.8654 GeneID:57326,Genbank:NM_001317735.1,HGNC:HGNC:21199 PBX homeobox interacting protein 1 GO:0003714,GO:0005634,GO:0005829,GO:0005874,GO:0007275,GO:0030154,GO:0045892 transcription corepressor activity|nucleus|cytosol|microtubule|multicellular organism development|cell differentiation|negative regulation of transcription, DNA-templated PC 814.041450713022 719.902685465108 908.180215960935 1.26153191854561 0.335176709005384 0.0370202193870132 0.744556882325193 3.60263 3.96085 4.82957 4.6489 GeneID:5091,Genbank:XM_017017871.1,HGNC:HGNC:8636,MIM:608786 pyruvate carboxylase hsa00020,hsa00620 Citrate cycle (TCA cycle)|Pyruvate metabolism PCBD1 897.039277072314 867.978650093676 926.099904050952 1.06696161702941 0.0935082774581715 0.575156243873182 1 21.1179 24.6475 24.662 24.3554 GeneID:5092,Genbank:NM_001323004.1,HGNC:HGNC:8646,MIM:126090 pterin-4 alpha-carbinolamine dehydratase 1 GO:0003713,GO:0004505,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006558,GO:0006729,GO:0008124,GO:0042802,GO:0043496,GO:0045893,GO:0051289,GO:0051291,GO:0070062 transcription coactivator activity|phenylalanine 4-monooxygenase activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|L-phenylalanine metabolic process|tetrahydrobiopterin biosynthetic process|4-alpha-hydroxytetrahydrobiopterin dehydratase activity|identical protein binding|regulation of protein homodimerization activity|positive regulation of transcription, DNA-templated|protein homotetramerization|protein heterooligomerization|extracellular exosome hsa00790 Folate biosynthesis PCBD2 285.765077470409 304.51155205488 267.018602885939 0.87687511716408 -0.189556703388438 0.344117526479741 1 5.9347 6.86088 5.14429 5.78582 GeneID:84105,Genbank:NM_032151.4,HGNC:HGNC:24474,MIM:609836 pterin-4 alpha-carbinolamine dehydratase 2 GO:0004505,GO:0005634,GO:0005739,GO:0006729,GO:0008124,GO:0045893,GO:0051289,GO:0051291 phenylalanine 4-monooxygenase activity|nucleus|mitochondrion|tetrahydrobiopterin biosynthetic process|4-alpha-hydroxytetrahydrobiopterin dehydratase activity|positive regulation of transcription, DNA-templated|protein homotetramerization|protein heterooligomerization hsa00790 Folate biosynthesis PCBP1 6393.42675857003 6523.21366770104 6263.63984943901 0.960207678073266 -0.0585816226755498 0.645356243685601 1 184.583 188.6 180.935 183.482 GeneID:5093,Genbank:NM_006196.3,HGNC:HGNC:8647,MIM:601209 poly(rC) binding protein 1 GO:0000981,GO:0003730,GO:0005829,GO:0016607,GO:0036464,GO:0039694,GO:0045296,GO:0045944,GO:0098847 RNA polymerase II transcription factor activity, sequence-specific DNA binding|mRNA 3'-UTR binding|cytosol|nuclear speck|cytoplasmic ribonucleoprotein granule|viral RNA genome replication|cadherin binding|positive regulation of transcription from RNA polymerase II promoter|sequence-specific single stranded DNA binding hsa03040,hsa04216 Spliceosome|Ferroptosis PCBP2 8038.28157375443 7942.13603944412 8134.42710806473 1.02421150527586 0.0345136705177418 0.801837882777486 1 77.6526 81.299 84.3203 81.2031 GeneID:5094,Genbank:NM_005016.5,HGNC:HGNC:8648,MIM:601210 poly(rC) binding protein 2 GO:0003677,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0019899,GO:0030529,GO:0031625,GO:0039694,GO:0043161,GO:0045087,GO:0050687,GO:0051607,GO:0075522,GO:1990829 DNA binding|RNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|enzyme binding|intracellular ribonucleoprotein complex|ubiquitin protein ligase binding|viral RNA genome replication|proteasome-mediated ubiquitin-dependent protein catabolic process|innate immune response|negative regulation of defense response to virus|defense response to virus|IRES-dependent viral translational initiation|C-rich single-stranded DNA binding hsa04216 Ferroptosis PCBP3 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00590379 0 0 0 GeneID:54039,Genbank:NM_001348239.1,HGNC:HGNC:8651,MIM:608502 poly(rC) binding protein 3 GO:0001227,GO:0003690,GO:0003723,GO:0005634,GO:0005829,GO:0016071,GO:0030529,GO:0070062,GO:1990829 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|double-stranded DNA binding|RNA binding|nucleus|cytosol|mRNA metabolic process|intracellular ribonucleoprotein complex|extracellular exosome|C-rich single-stranded DNA binding PCBP4 880.636571720477 870.601494891986 890.671648548967 1.02305320376169 0.0328811742203423 0.873337642709749 1 8.22957 8.87684 8.62496 9.72968 GeneID:57060,Genbank:NM_033008.2,HGNC:HGNC:8652,MIM:608503 poly(rC) binding protein 4 GO:0003677,GO:0003723,GO:0003730,GO:0005829,GO:0006977,GO:0030529,GO:0043488 DNA binding|RNA binding|mRNA 3'-UTR binding|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|intracellular ribonucleoprotein complex|regulation of mRNA stability PCCA 158.338396010254 150.448869398346 166.227922622162 1.10487983915677 0.143889478323576 0.552012371885016 1 0.560703 0.408231 0.57125 0.544677 GeneID:5095,Genbank:NM_000282.3,HGNC:HGNC:8653,MIM:232000 propionyl-CoA carboxylase alpha subunit GO:0004075,GO:0004658,GO:0005524,GO:0005759,GO:0005829,GO:0006768,GO:0009374,GO:0019626,GO:0019899,GO:0046872 biotin carboxylase activity|propionyl-CoA carboxylase activity|ATP binding|mitochondrial matrix|cytosol|biotin metabolic process|biotin binding|short-chain fatty acid catabolic process|enzyme binding|metal ion binding hsa00280,hsa00630,hsa00640 Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism PCCB 991.211723003718 963.78946250133 1018.63398350611 1.05690508470848 0.0798458214047341 0.607265368332468 1 14.906 15.6562 15.2328 17.5167 GeneID:5096,Genbank:NM_001178014.1,HGNC:HGNC:8654,MIM:232050 propionyl-CoA carboxylase beta subunit GO:0004658,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006768,GO:0009062,GO:0016421,GO:0019626 propionyl-CoA carboxylase activity|ATP binding|mitochondrion|mitochondrial matrix|cytosol|biotin metabolic process|fatty acid catabolic process|CoA carboxylase activity|short-chain fatty acid catabolic process hsa00280,hsa00630,hsa00640 Valine, leucine and isoleucine degradation|Glyoxylate and dicarboxylate metabolism|Propanoate metabolism PCDH1 89.6814315257974 94.5533376115923 84.8095254400024 0.896949040428211 -0.156902073187571 0.614218643186702 1 0.346107 0.350523 0.327191 0.301913 GeneID:5097,Genbank:XM_005268452.3,HGNC:HGNC:8655,MIM:603626 protocadherin 1 GO:0005509,GO:0005634,GO:0005730,GO:0005886,GO:0005887,GO:0005911,GO:0007156,GO:0007267,GO:0007399,GO:0030054,GO:0043231 calcium ion binding|nucleus|nucleolus|plasma membrane|integral component of plasma membrane|cell-cell junction|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|cell junction|intracellular membrane-bounded organelle PCDH10 256.729599721609 194.535678264293 318.923521178926 1.63940889416512 0.713175729978449 0.00181049649336921 0.152615325462112 0.789431 0.881616 1.56782 1.16573 GeneID:57575,Genbank:NM_032961.2,HGNC:HGNC:13404,MIM:608286 protocadherin 10 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDH12 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0052488 0 0 GeneID:51294,Genbank:NM_016580.3,HGNC:HGNC:8657,MIM:605622 protocadherin 12 GO:0005509,GO:0005886,GO:0005887,GO:0005911,GO:0005977,GO:0007155,GO:0007156,GO:0007267,GO:0008038,GO:0016339,GO:0060711,GO:0070062 calcium ion binding|plasma membrane|integral component of plasma membrane|cell-cell junction|glycogen metabolic process|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|neuron recognition|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|labyrinthine layer development|extracellular exosome PCDH17 610.033055594898 587.506971697466 632.55913949233 1.07668363094432 0.106594395547673 0.729257696633441 1 2.20247 1.85926 2.70962 1.71293 GeneID:27253,Genbank:XM_005266357.2,HGNC:HGNC:14267,MIM:611760 protocadherin 17 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007416,GO:0030534,GO:0050805,GO:1904071,GO:2000807 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|synapse assembly|adult behavior|negative regulation of synaptic transmission|presynaptic active zone assembly|regulation of synaptic vesicle clustering PCDH18 53.3117934996714 47.4878827143244 59.1357042850183 1.2452798673035 0.316470013615526 0.417214925360498 1 0.300885 0.189374 0.405896 0.257806 GeneID:54510,Genbank:NM_001300828.1,HGNC:HGNC:14268,MIM:608287 protocadherin 18 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399,GO:0007420 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|brain development PCDH19 13.4270088310881 14.7403596782979 12.1136579838783 0.821802062382043 -0.283137143811566 0.741761701882091 1 0.0559292 0.0833451 0.0479598 0.0625801 GeneID:57526,Genbank:NM_020766.2,HGNC:HGNC:14270,MIM:300460 protocadherin 19 PCDH20 684.281571330292 637.656933830533 730.90620883005 1.14623737318961 0.196905841356146 0.321367779884424 1 5.82051 5.51769 7.67829 5.58371 GeneID:64881,Genbank:NM_022843.3,HGNC:HGNC:14257,MIM:614449 protocadherin 20 GO:0003723,GO:0005509,GO:0005886,GO:0007156,GO:0016021 RNA binding|calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane PCDH7 386.210358259519 350.249854569476 422.170861949561 1.20534200497668 0.269442556311683 0.291560139465918 1 1.21908 1.05868 1.64786 1.14607 GeneID:5099,Genbank:XM_011513842.3,HGNC:HGNC:8659,MIM:602988 protocadherin 7 GO:0002576,GO:0005509,GO:0005886,GO:0005887,GO:0007156,GO:0031092 platelet degranulation|calcium ion binding|plasma membrane|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|platelet alpha granule membrane PCDH8 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0178935 0 0.0163428 0 GeneID:5100,Genbank:NM_032949.2,HGNC:HGNC:8660,MIM:603580 protocadherin 8 GO:0001756,GO:0005509,GO:0005886,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007268,GO:0007399,GO:0016331,GO:0030054,GO:0030425,GO:0042734,GO:0045211 somitogenesis|calcium ion binding|plasma membrane|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|chemical synaptic transmission|nervous system development|morphogenesis of embryonic epithelium|cell junction|dendrite|presynaptic membrane|postsynaptic membrane PCDH9 84.1054302391401 69.3195647383421 98.8912957399381 1.42660006757427 0.51258094701062 0.349444665812521 1 0.126158 0.0887177 0.213649 0.109346 GeneID:5101,Genbank:NM_001318373.1,HGNC:HGNC:8661,MIM:603581 protocadherin 9 GO:0005509,GO:0005886,GO:0007156,GO:0016021,GO:0030426,GO:0030900,GO:0044291 calcium ion binding|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|integral component of membrane|growth cone|forebrain development|cell-cell contact zone PCDHA1 8.54010751802003 7.38928864893743 9.69092638710264 1.31148299214109 0.391199098252677 0.709916434830649 1 0.168004 0.0532766 0.150352 0.169644 GeneID:56147,Genbank:NM_018900.3,HGNC:HGNC:8663,MIM:606307 protocadherin alpha 1 GO:0005509,GO:0005576,GO:0005783,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|extracellular region|endoplasmic reticulum|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHA10 3.98606181630583 2.64246210852658 5.32966152408509 2.01693016028028 1.0121611289872 0.542652051158346 1 0.0609835 0.0178242 0.0752866 0.0987391 GeneID:56139,Genbank:NM_018901.3,HGNC:HGNC:8664,MIM:606316 protocadherin alpha 10 GO:0005509,GO:0005576,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|extracellular region|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHA13 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0164315 1.90854e-08 2.29403e-08 1.15403e-08 GeneID:56136,Genbank:NM_018904.2,HGNC:HGNC:8667,MIM:606319 protocadherin alpha 13 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHA2 1.21093081236113 0 2.42186162472226 Inf Inf 0.339679181581212 1 2.03102e-09 1.00138e-09 0.0162093 0.050337 GeneID:56146,Genbank:NM_018905.2,HGNC:HGNC:8668,MIM:606308 protocadherin alpha 2 GO:0005509,GO:0005634,GO:0005783,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|nucleus|endoplasmic reticulum|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHA3 1.0016543915721 1.51824048055703 0.48506830258717 0.319493722370782 -1.64614051048666 0.791481013618379 1 0.0162816 1.5511e-08 0.0204561 1.09141e-08 GeneID:56145,Genbank:NM_018906.2,HGNC:HGNC:8669,MIM:606309 protocadherin alpha 3 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHA4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 1.6267e-08 1.3638e-08 0.0203005 9.99966e-09 GeneID:56144,Genbank:NM_018907.3,HGNC:HGNC:8670,MIM:606310 protocadherin alpha 4 GO:0005509,GO:0005783,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399,GO:0042802,GO:0045202 calcium ion binding|endoplasmic reticulum|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|identical protein binding|synapse PCDHA7 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 2.18677e-08 1.90882e-08 2.41841e-08 0.0309933 GeneID:56141,Genbank:NM_018910.2,HGNC:HGNC:8673,MIM:606313 protocadherin alpha 7 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399,GO:0009988,GO:0042802 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|cell-cell recognition|identical protein binding PCDHA8 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0182208 6.39163e-08 9.09586e-08 3.55945e-08 GeneID:56140,Genbank:NM_018911.2,HGNC:HGNC:8674,MIM:606314 protocadherin alpha 8 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHA9 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 6.79895e-13 2.37157e-14 6.665e-15 0.00661745 GeneID:9752,Genbank:NM_031857.1,HGNC:HGNC:8675,MIM:606315 protocadherin alpha 9 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHAC1 1.75827308216552 2.54640955915669 0.97013660517434 0.380982156497883 -1.39220466497676 0.672283656149566 1 0.0142361 0.0161494 0.0341392 2.1408e-09 GeneID:56135,Genbank:NM_018898.3,HGNC:HGNC:8676,MIM:606320 protocadherin alpha subfamily C, 1 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHAC2 16.9630000194181 18.9010622673815 15.0249377714547 0.794925573965439 -0.331108302537342 0.653900728164507 1 0.172649 0.260397 0.224565 0.147323 GeneID:56134,Genbank:NM_018899.5,HGNC:HGNC:8677,MIM:606321 protocadherin alpha subfamily C, 2 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHB10 103.022312348657 96.4940059092059 109.550618788108 1.13531009264128 0.183086401493454 0.651271613819186 1 1.48506 1.17788 1.84634 1.1752 GeneID:56126,Genbank:NM_018930.3,HGNC:HGNC:8681,MIM:606336 protocadherin beta 10 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHB11 8.65963944688947 6.65908587355536 10.6601930202236 1.60084930914579 0.67883751073991 0.524331378641624 1 0.0618125 0.0697154 0.144833 0.176087 GeneID:56125,Genbank:NM_018931.2,HGNC:HGNC:8682,MIM:606337 protocadherin beta 11 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHB12 6.48575005885768 7.63922867747008 5.33227144024528 0.698011758172841 -0.518676755709211 0.696019774220114 1 0.0818507 0.113443 0.0905292 0.0482717 GeneID:56124,Genbank:NM_018932.3,HGNC:HGNC:8683,MIM:606338 protocadherin beta 12 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly PCDHB13 9.4810336543852 10.7237359132691 8.23833139550132 0.768233334178583 -0.380383530119184 0.723568828392164 1 0.111099 0.152661 0.0915879 0.122155 GeneID:56123,Genbank:NM_018933.3,HGNC:HGNC:8684,MIM:606339 protocadherin beta 13 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHB14 225.89397129026 194.429817059815 257.358125520705 1.32365564815365 0.404527850758011 0.0646675235754651 0.90091963811897 1.89309 2.02704 2.91061 2.35182 GeneID:56122,Genbank:NM_018934.3,HGNC:HGNC:8685,MIM:606340 protocadherin beta 14 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHB15 13.3559252567355 10.7237359132691 15.9881146002019 1.49090901990778 0.576192222388201 0.489205436382729 1 0.158561 0.189942 0.18144 0.324425 GeneID:56121,Genbank:NM_018935.3,HGNC:HGNC:8686,MIM:606341 protocadherin beta 15 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0032391 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|photoreceptor connecting cilium PCDHB16 249.910257361723 218.23159334677 281.588921376675 1.29032152062983 0.367730599308884 0.0842978378155851 0.963678922522777 2.06716 2.27689 3.11219 2.59338 GeneID:57717,Genbank:NM_020957.3,HGNC:HGNC:14546,MIM:606345 protocadherin beta 16 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHB2 182.560160694476 141.695227748014 223.425093640938 1.57680041305463 0.657000059418809 0.00529864190894414 0.285941071095182 2.25468 2.23587 3.87127 3.31975 GeneID:56133,Genbank:NM_018936.3,HGNC:HGNC:8687,MIM:606328 protocadherin beta 2 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHB3 14.6194729579787 15.1824048055703 14.0565411103872 0.925844178863545 -0.111158688979688 0.90691768748798 1 0.137645 0.251415 0.220798 0.145481 GeneID:56132,Genbank:NM_018937.4,HGNC:HGNC:8688,MIM:606329 protocadherin beta 3 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHB4 2.48206902828108 2.05633815719933 2.90779989936283 1.41406698561834 0.499850463520999 0.908170413273276 1 0.0259441 0.0240014 0.0369054 0.0344607 GeneID:56131,Genbank:NM_018938.3,HGNC:HGNC:8689,MIM:606330 protocadherin beta 4 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007399,GO:0007416,GO:0016021,GO:0016339 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|nervous system development|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHB5 2.58606121273295 3.71865746181119 1.45346496365472 0.390857447501174 -1.3552855673609 0.583356108377211 1 0.0778807 0.0278226 0.0292242 0.040864 GeneID:26167,Genbank:NM_015669.4,HGNC:HGNC:8690,MIM:606331 protocadherin beta 5 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHB7 144.500056202592 115.020666634216 173.979445770969 1.51259291796883 0.597023769280041 0.0213584525117587 0.598036670329243 1.29394 1.49348 2.12452 2.12203 GeneID:56129,Genbank:NM_018940.3,HGNC:HGNC:8692,MIM:606333 protocadherin beta 7 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly PCDHB8 10.1981949234989 8.76345030543964 11.6329395415581 1.32743829611692 0.408644801176274 0.685867914219128 1 0.155064 0.10818 0.177108 0.150368 GeneID:56128,Genbank:NM_019120.4,HGNC:HGNC:8693,MIM:606334 protocadherin beta 8 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0042802 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|identical protein binding PCDHB9 202.916381347785 170.772119596915 235.060643098656 1.37645795843892 0.460960545946592 0.0406692144507182 0.759435523043776 1.86583 1.69881 2.68029 2.24427 GeneID:56127,Genbank:NM_019119.4,HGNC:HGNC:8694,MIM:606335 protocadherin beta 9 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007268,GO:0007416,GO:0016021,GO:0016339 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|chemical synaptic transmission|synapse assembly|integral component of membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHGA1 29.431753192247 17.6709794349341 41.19252694956 2.3310834071894 1.22100062565328 0.0193931814855361 0.567967248609484 0.368064 0.195635 0.585504 0.532282 GeneID:56114,Genbank:NM_018912.2,HGNC:HGNC:8696,MIM:606288 protocadherin gamma subfamily A, 1 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGA10 2.75405440231403 3.084507235799 2.42360156882906 0.78573379264622 -0.347887486068969 0.960569308196642 1 0.0596669 0.0368908 0.0551387 0.0343788 GeneID:56106,Genbank:NM_018913.2,HGNC:HGNC:8697,MIM:606297 protocadherin gamma subfamily A, 10 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007283,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|spermatogenesis|nervous system development PCDHGA11 1.21473732012632 0.490071401957362 1.93940323829528 3.95738912850095 1.98454893191584 0.683483673443307 1 3.89787e-08 0.0156962 0.0313431 0.014633 GeneID:56105,Genbank:NM_018914.2,HGNC:HGNC:8698,MIM:606298 protocadherin gamma subfamily A, 11 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGA12 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 8.27669e-08 0.0161198 1.08472e-08 3.9056e-08 GeneID:26025,Genbank:NM_003735.2,HGNC:HGNC:8699,MIM:603059 protocadherin gamma subfamily A, 12 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGA2 9.5543651182979 6.02493564754317 13.0837945890526 2.17160735889153 1.118763277826 0.260495905825339 1 0.0364238 0.132365 0.167066 0.234546 GeneID:56113,Genbank:NM_018915.3,HGNC:HGNC:8700,MIM:606289 protocadherin gamma subfamily A, 2 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGA3 2.53553338836291 3.13253351048394 1.93853326624189 0.61883879605885 -0.692364450254232 0.833281817632912 1 0.0774079 0.0177438 0.0355925 0.0166607 GeneID:56112,Genbank:NM_018916.3,HGNC:HGNC:8701,MIM:606290 protocadherin gamma subfamily A, 3 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGA4 39.8723834952233 25.464095591567 54.2806713988796 2.13165518499137 1.09197408765833 0.0174506749092373 0.545445222117836 0.270865 0.428187 0.800881 0.734583 GeneID:56111,Genbank:NM_018917.3,HGNC:HGNC:8702,MIM:606291 protocadherin gamma subfamily A, 4 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGA5 10.2297127098966 10.2816907859967 10.1777346337966 0.989889196790313 -0.0146610486723792 1 1 0.0971893 0.177243 0.160879 0.133677 GeneID:56110,Genbank:NM_018918.2,HGNC:HGNC:8703,MIM:606292 protocadherin gamma subfamily A, 5 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGA6 11.7130638823174 11.3098598645963 12.1162679000385 1.0713013286722 0.0993643290489248 0.958960205622818 1 0.211177 0.191821 0.176308 0.148625 GeneID:56109,Genbank:NM_018919.2,HGNC:HGNC:8704,MIM:606293 protocadherin gamma subfamily A, 6 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGA7 4.42060229452297 2.05633815719933 6.7848664318466 3.29948963310946 1.72224288485745 0.268264750750848 1 0.0304177 0.0282855 0.098917 0.0925611 GeneID:56108,Genbank:NM_018920.3,HGNC:HGNC:8705,MIM:606294 protocadherin gamma subfamily A, 7 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGA8 2.19531511006775 2.45035700978681 1.94027321034868 0.791832864598572 -0.336732147992416 0.970001111225851 1 2.34082e-09 0.0651475 0.0514644 1.22988e-09 GeneID:9708,Genbank:NM_032088.1,HGNC:HGNC:8706,MIM:606295 protocadherin gamma subfamily A, 8 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGA9 216.683246430569 177.479231745155 255.887261115982 1.44178706770274 0.527858113918167 0.0165979059849306 0.534873364697483 2.71048 2.66971 4.24049 3.98865 GeneID:56107,Genbank:NM_018921.2,HGNC:HGNC:8707,MIM:606296 protocadherin gamma subfamily A, 9 GO:0003723,GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 RNA binding|calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGB1 102.633985866795 78.7651915444789 126.502780189111 1.60607468487745 0.683538981894501 0.0329508462158114 0.717059810541268 1.51797 1.00574 2.2808 1.66019 GeneID:56104,Genbank:NM_018922.2,HGNC:HGNC:8708,MIM:606299 protocadherin gamma subfamily B, 1 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399,GO:0030426 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|growth cone PCDHGB2 403.953877887859 305.818070126481 502.089685649236 1.64179208063663 0.715271433310831 0.000105851499745494 0.0235460780544978 4.79912 4.68798 7.93115 7.29827 GeneID:56103,Genbank:NM_018923.2,HGNC:HGNC:8709,MIM:606300 protocadherin gamma subfamily B, 2 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGB3 11.9316932627436 10.771762187954 13.0916243375332 1.21536514723408 0.281389825732229 0.807096910092522 1 0.156486 0.160496 0.338073 0.0900041 GeneID:56102,Genbank:NM_018924.4,HGNC:HGNC:8710,MIM:606301 protocadherin gamma subfamily B, 3 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGB4 1.02523254288787 1.56626675524197 0.484198330533773 0.309141676482158 -1.69365993276169 0.789571303159055 1 0.0409101 0.0189254 8.27923e-08 0.0176236 GeneID:8641,Genbank:NM_003736.2,HGNC:HGNC:8711,MIM:603058 protocadherin gamma subfamily B, 4 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399,GO:0016020,GO:0016339 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PCDHGB5 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0.0189562 0.0353394 3.24117e-08 1.03793e-07 GeneID:56101,Genbank:NM_018925.2,HGNC:HGNC:8712,MIM:606302 protocadherin gamma subfamily B, 5 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399,GO:0070062 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|extracellular exosome PCDHGB6 5.43150127925715 5.04479284362845 5.81820971488585 1.15330993664769 0.205780270125185 0.967116206132323 1 0.0388945 0.12708 0.0901035 0.033718 GeneID:56100,Genbank:NM_018926.2,HGNC:HGNC:8713,MIM:606303 protocadherin gamma subfamily B, 6 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGB7 1.96798448898125 1.02816907859967 2.90779989936283 2.82813397123668 1.499850463521 0.612249728970674 1 0.0177968 0.0165972 0.0495119 0.0617885 GeneID:56099,Genbank:NM_032101.2,HGNC:HGNC:8714,MIM:606304 protocadherin gamma subfamily B, 7 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGC3 3034.29411946242 2470.09843127198 3598.48980765287 1.45682040929835 0.542823038978233 7.63934173525191e-05 0.0200576552839008 37.4457 40.2163 59.8326 52.6536 GeneID:5098,Genbank:NM_002588.3,HGNC:HGNC:8716,MIM:603627 protocadherin gamma subfamily C, 3 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399,GO:0016020,GO:0016339,GO:0050808,GO:0070062 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|membrane|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|synapse organization|extracellular exosome PCDHGC4 6.94256373031049 7.10113100082778 6.7839964597932 0.955340277344889 -0.0659134046717328 1 1 0.0393915 0.108348 0.108912 0.084868 GeneID:56098,Genbank:NM_018928.2,HGNC:HGNC:8717,MIM:606305 protocadherin gamma subfamily C, 4 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development PCDHGC5 6.67231830038434 6.07296192222811 7.27167467854057 1.19738519221156 0.25988733398451 0.900482777777175 1 0.0554608 0.133126 0.169625 0.0792879 GeneID:56097,Genbank:NM_018929.2,HGNC:HGNC:8718,MIM:606306 protocadherin gamma subfamily C, 5 GO:0005509,GO:0005887,GO:0007155,GO:0007156,GO:0007267,GO:0007399,GO:0050808,GO:0070062 calcium ion binding|integral component of plasma membrane|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|cell-cell signaling|nervous system development|synapse organization|extracellular exosome PCED1A 267.197390771107 236.354426564084 298.040354978129 1.2609890972248 0.334555801877301 0.110900041237805 1 3.84137 4.20535 5.61528 5.28447 GeneID:64773,Genbank:NM_001271168.1,HGNC:HGNC:16212 PC-esterase domain containing 1A PCED1B 259.946392218732 268.881435536902 251.011348900562 0.933539157879543 -0.0992175564275327 0.672996209407674 1 1.35582 1.79179 1.30938 1.63413 GeneID:91523,Genbank:NM_138371.2,HGNC:HGNC:28255 PC-esterase domain containing 1B PCF11 309.229814561684 306.798212930396 311.661416192973 1.01585147193696 0.0226894804917262 0.926581845843728 1 1.29157 1.36985 1.61996 1.13465 GeneID:51585,Genbank:NM_001346413.1,HGNC:HGNC:30097,MIM:608876 PCF11 cleavage and polyadenylation factor subunit GO:0000398,GO:0000993,GO:0003729,GO:0005654,GO:0005737,GO:0005739,GO:0005849,GO:0006369,GO:0006378,GO:0006379,GO:0031124 mRNA splicing, via spliceosome|RNA polymerase II core binding|mRNA binding|nucleoplasm|cytoplasm|mitochondrion|mRNA cleavage factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA cleavage|mRNA 3'-end processing hsa03015 mRNA surveillance pathway PCGF1 233.827808279044 241.361001788136 226.294614769951 0.937577376185199 -0.0929903370504213 0.708695507306208 1 5.04671 6.54257 4.92646 6.53145 GeneID:84759,Genbank:NM_032673.2,HGNC:HGNC:17615,MIM:610231 polycomb group ring finger 1 GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0008022,GO:0031519,GO:0035518,GO:0036353,GO:0046872 nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|protein C-terminus binding|PcG protein complex|histone H2A monoubiquitination|histone H2A-K119 monoubiquitination|metal ion binding hsa04550 Signaling pathways regulating pluripotency of stem cells PCGF2 1550.7725166994 1499.88020561541 1601.66482778339 1.06786183442311 0.0947249956328914 0.525892311889316 1 11.8236 12.2623 12.9036 13.123 GeneID:7703,Genbank:NM_007144.2,HGNC:HGNC:12929,MIM:600346 polycomb group ring finger 2 GO:0000122,GO:0000790,GO:0001701,GO:0001739,GO:0003677,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0009952,GO:0016573,GO:0016604,GO:0031519,GO:0035102,GO:0036353,GO:0046872,GO:0048704,GO:0070301,GO:0070317,GO:2001234 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|in utero embryonic development|sex chromatin|DNA binding|chromatin binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|anterior/posterior pattern specification|histone acetylation|nuclear body|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|metal ion binding|embryonic skeletal system morphogenesis|cellular response to hydrogen peroxide|negative regulation of G0 to G1 transition|negative regulation of apoptotic signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells PCGF3 1719.05929720914 1711.78686300971 1726.33173140856 1.00849689217341 0.0122066380877907 0.924279173696094 1 12.3082 11.4981 13.1181 11.1937 GeneID:10336,Genbank:NM_001317836.1,HGNC:HGNC:10066,MIM:617543 polycomb group ring finger 3 GO:0000805,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0031519,GO:0036353,GO:0046872,GO:0060819 X chromosome|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|PcG protein complex|histone H2A-K119 monoubiquitination|metal ion binding|inactivation of X chromosome by genetic imprinting hsa04550 Signaling pathways regulating pluripotency of stem cells PCGF5 412.157694823818 403.090305085754 421.225084561882 1.04498937148158 0.0634882688240626 0.838056993581699 1 1.92699 1.76089 2.41608 1.35553 GeneID:84333,Genbank:XM_017016776.2,HGNC:HGNC:28264,MIM:617407 polycomb group ring finger 5 GO:0005634,GO:0005654,GO:0005730,GO:0005813,GO:0006351,GO:0031519,GO:0036353,GO:0045944,GO:0046872,GO:0060819 nucleus|nucleoplasm|nucleolus|centrosome|transcription, DNA-templated|PcG protein complex|histone H2A-K119 monoubiquitination|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|inactivation of X chromosome by genetic imprinting hsa04550 Signaling pathways regulating pluripotency of stem cells PCGF6 314.49602657634 323.171465947982 305.820587204699 0.946310610398766 -0.0796142934255983 0.71916345470819 1 6.4222 5.42115 6.38857 5.53689 GeneID:84108,Genbank:NM_032154.3,HGNC:HGNC:21156,MIM:607816 polycomb group ring finger 6 GO:0000977,GO:0001227,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0031519,GO:0035102,GO:0036353,GO:0045892,GO:0046872,GO:0070317 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|PcG protein complex|PRC1 complex|histone H2A-K119 monoubiquitination|negative regulation of transcription, DNA-templated|metal ion binding|negative regulation of G0 to G1 transition hsa04550 Signaling pathways regulating pluripotency of stem cells PCID2 974.935270595711 1003.88805656672 945.982484624705 0.942318696229889 -0.0857130268628812 0.574829410830434 1 1.99738 1.89876 1.90326 1.80873 GeneID:55795,Genbank:NM_001353091.1,HGNC:HGNC:25653,MIM:613713 PCI domain containing 2 GO:0000973,GO:0003690,GO:0003723,GO:0006368,GO:0016973,GO:0043066,GO:0043488,GO:0045579,GO:0045893,GO:0048536,GO:0070390,GO:0071033,GO:0090267,GO:2000117 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery|double-stranded DNA binding|RNA binding|transcription elongation from RNA polymerase II promoter|poly(A)+ mRNA export from nucleus|negative regulation of apoptotic process|regulation of mRNA stability|positive regulation of B cell differentiation|positive regulation of transcription, DNA-templated|spleen development|transcription export complex 2|nuclear retention of pre-mRNA at the site of transcription|positive regulation of mitotic cell cycle spindle assembly checkpoint|negative regulation of cysteine-type endopeptidase activity PCIF1 924.610881935974 955.555318218279 893.66644565367 0.935232559136391 -0.0966029382353495 0.516298171620833 1 11.1475 11.7441 11.3591 10.5516 GeneID:63935,Genbank:NM_022104.3,HGNC:HGNC:16200 PDX1 C-terminal inhibiting factor 1 GO:0005654,GO:0010923,GO:0015630,GO:0045171 nucleoplasm|negative regulation of phosphatase activity|microtubule cytoskeleton|intercellular bridge PCK1 7.781323491952 4.90071401957362 10.6619329643304 2.17558766370497 1.12140515038538 0.334362790818735 1 0 0.134172 0.140367 0.130263 GeneID:5105,Genbank:NM_002591.3,HGNC:HGNC:8724,MIM:614168 phosphoenolpyruvate carboxykinase 1 hsa00010,hsa00020,hsa00620,hsa03320,hsa04068,hsa04151,hsa04152,hsa04910,hsa04920,hsa04922,hsa04931,hsa04964 Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism|PPAR signaling pathway|FoxO signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Proximal tubule bicarbonate reclamation PCK2 533.623239216513 480.472543319478 586.773935113549 1.22124342643944 0.288350796651183 0.416830216710896 1 5.635 5.36232 5.44157 8.31662 GeneID:5106,Genbank:NM_001291556.1,HGNC:HGNC:8725,MIM:614095 phosphoenolpyruvate carboxykinase 2, mitochondrial GO:0004611,GO:0004613,GO:0005525,GO:0005739,GO:0005759,GO:0006090,GO:0006094,GO:0006107,GO:0006116,GO:0032024,GO:0032496,GO:0046872,GO:0070062,GO:0071333,GO:0071356,GO:0071548 phosphoenolpyruvate carboxykinase activity|phosphoenolpyruvate carboxykinase (GTP) activity|GTP binding|mitochondrion|mitochondrial matrix|pyruvate metabolic process|gluconeogenesis|oxaloacetate metabolic process|NADH oxidation|positive regulation of insulin secretion|response to lipopolysaccharide|metal ion binding|extracellular exosome|cellular response to glucose stimulus|cellular response to tumor necrosis factor|response to dexamethasone hsa00010,hsa00020,hsa00620,hsa03320,hsa04068,hsa04151,hsa04152,hsa04910,hsa04920,hsa04922,hsa04931,hsa04964 Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism|PPAR signaling pathway|FoxO signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Proximal tubule bicarbonate reclamation PCLAF 1806.82823327534 1875.85187045839 1737.8045960923 0.926408222024292 -0.110280037349252 0.446464589499021 1 50.8096 49.8742 45.3304 47.898 GeneID:9768,Genbank:NM_001029989.2,HGNC:HGNC:28961,MIM:610696 PCNA clamp associated factor PCLO 714.427933431038 640.654180171215 788.20168669086 1.23030756855471 0.299019024637316 0.501313560476466 1 0.78511 0.68783 1.18573 0.635896 GeneID:27445,Genbank:NM_033026.5,HGNC:HGNC:13406,MIM:604918 piccolo presynaptic cytomatrix protein GO:0005509,GO:0005522,GO:0005544,GO:0005856,GO:0007010,GO:0007416,GO:0014069,GO:0016020,GO:0016079,GO:0017157,GO:0019933,GO:0030054,GO:0030073,GO:0035418,GO:0045202,GO:0048788,GO:0070062,GO:0099526 calcium ion binding|profilin binding|calcium-dependent phospholipid binding|cytoskeleton|cytoskeleton organization|synapse assembly|postsynaptic density|membrane|synaptic vesicle exocytosis|regulation of exocytosis|cAMP-mediated signaling|cell junction|insulin secretion|protein localization to synapse|synapse|cytoskeleton of presynaptic active zone|extracellular exosome|presynapse to nucleus signaling pathway hsa04911 Insulin secretion PCM1 374.934818184247 349.951888266258 399.917748102236 1.14277922626313 0.192546715941032 0.650066366888273 1 0.965472 0.855778 1.35267 0.717503 GeneID:5108,Genbank:XM_011544528.2,HGNC:HGNC:8727,MIM:600299 pericentriolar material 1 GO:0000086,GO:0000242,GO:0001764,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0007098,GO:0010389,GO:0016020,GO:0022027,GO:0031122,GO:0031965,GO:0034451,GO:0034453,GO:0034454,GO:0035176,GO:0035735,GO:0035869,GO:0036064,GO:0042802,GO:0043234,GO:0045177,GO:0050768,GO:0060271,GO:0071539,GO:0090316,GO:0097150,GO:0097711,GO:1905515 G2/M transition of mitotic cell cycle|pericentriolar material|neuron migration|cytoplasm|centrosome|centriole|cytosol|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|membrane|interkinetic nuclear migration|cytoplasmic microtubule organization|nuclear membrane|centriolar satellite|microtubule anchoring|microtubule anchoring at centrosome|social behavior|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|identical protein binding|protein complex|apical part of cell|negative regulation of neurogenesis|cilium assembly|protein localization to centrosome|positive regulation of intracellular protein transport|neuronal stem cell population maintenance|ciliary basal body-plasma membrane docking|non-motile cilium assembly PCMT1 3528.32754924862 3455.36275756346 3601.29234093377 1.042232782376 0.0596775391063027 0.662654391671586 1 46.4819 48.808 51.5188 49.1772 GeneID:5110,Genbank:NM_005389.2,HGNC:HGNC:8728,MIM:176851 protein-L-isoaspartate (D-aspartate) O-methyltransferase GO:0004719,GO:0005737,GO:0005829,GO:0006479,GO:0030091,GO:0045296,GO:0070062,GO:1903561 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity|cytoplasm|cytosol|protein methylation|protein repair|cadherin binding|extracellular exosome|extracellular vesicle PCMTD1 158.629937461093 183.484550082482 133.775324839705 0.729082229427864 -0.455846557018829 0.168399813816578 1 1.72867 1.24577 1.26391 0.933463 GeneID:115294,Genbank:NM_001286782.1,HGNC:HGNC:30483 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 GO:0004719,GO:0005737,GO:0016020 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity|cytoplasm|membrane PCMTD2 442.898771484766 418.589276503903 467.208266465629 1.11614963089307 0.158530447666097 0.35824146493651 1 5.20776 4.49695 5.76912 5.02744 GeneID:55251,Genbank:NM_018257.2,HGNC:HGNC:15882 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 GO:0004719,GO:0005737 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity|cytoplasm PCNA 4173.31697443401 4213.42910944803 4133.20483941998 0.980959862396127 -0.0277339875016781 0.846542184834714 1 122.674 120.594 117.109 123.361 GeneID:5111,Genbank:NM_002592.2,HGNC:HGNC:8729,MIM:176740 proliferating cell nuclear antigen hsa03030,hsa03410,hsa03420,hsa03430,hsa04110,hsa04530,hsa05161,hsa05166 DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Cell cycle|Tight junction|Hepatitis B|Human T-cell leukemia virus 1 infection PCNP 1904.17518891947 2091.75655130836 1716.59382653058 0.8206470420551 -0.285166238494613 0.0467219106937611 0.79332376136203 33.4846 31.4337 28.1745 25.1754 GeneID:57092,Genbank:NM_001320399.1,HGNC:HGNC:30023,MIM:615210 PEST proteolytic signal containing nuclear protein GO:0005634,GO:0007049,GO:0016567,GO:0016604,GO:0043161 nucleus|cell cycle|protein ubiquitination|nuclear body|proteasome-mediated ubiquitin-dependent protein catabolic process PCNT 1883.28341798426 1922.41744529859 1844.14939066994 0.959286649827245 -0.0599661154200341 0.681840655389162 1 5.77949 5.49077 6.03162 4.80484 GeneID:5116,Genbank:XM_011529594.3,HGNC:HGNC:16068,MIM:605925 pericentrin GO:0000086,GO:0000226,GO:0005516,GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0005874,GO:0007052,GO:0007165,GO:0010389,GO:0016020,GO:0032947,GO:0034451,GO:0060271,GO:0090316,GO:0097711 G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|calmodulin binding|centrosome|centriole|microtubule organizing center|cytosol|microtubule|mitotic spindle organization|signal transduction|regulation of G2/M transition of mitotic cell cycle|membrane|protein complex scaffold activity|centriolar satellite|cilium assembly|positive regulation of intracellular protein transport|ciliary basal body-plasma membrane docking PCNX1 785.639113824228 776.83416098386 794.444066664596 1.02266880959307 0.0323390051829793 0.899862700586853 1 2.45134 2.19668 2.91656 1.88739 GeneID:22990,Genbank:NM_014982.2,HGNC:HGNC:19740,MIM:617655 pecanex homolog 1 GO:0016021 integral component of membrane PCNX2 471.060184028694 451.635782844002 490.484585213386 1.08601799025921 0.119048002076683 0.507880872222084 1 1.73971 1.70783 1.99048 1.55348 GeneID:80003,Genbank:XM_017002391.1,HGNC:HGNC:8736,MIM:617656 pecanex homolog 2 GO:0016021 integral component of membrane PCNX3 1478.34734653949 1062.18693608943 1894.50775698956 1.78359165662912 0.834785356071957 1.20208743915781e-08 1.60438603546262e-05 5.18376 5.36789 10.5488 8.97834 GeneID:399909,Genbank:XM_011545024.2,HGNC:HGNC:18760,MIM:617657 pecanex homolog 3 GO:0016021 integral component of membrane PCNX4 874.731615728751 926.4479834032 823.015248054302 0.88835559340423 -0.170790816789389 0.407593413639409 1 8.95319 8.86632 9.48135 6.68579 GeneID:64430,Genbank:NM_001330177.1,HGNC:HGNC:20349 pecanex homolog 4 GO:0016021 integral component of membrane PCOLCE 82.1111210872052 81.8310984709168 82.3911437034937 1.00684391683653 0.00984005091273917 1 1 0.921497 1.47832 1.49592 1.17134 GeneID:5118,Genbank:NM_002593.3,HGNC:HGNC:8738,MIM:600270 procollagen C-endopeptidase enhancer GO:0005518,GO:0005576,GO:0005615,GO:0006508,GO:0007275,GO:0008201,GO:0016504,GO:0070062,GO:1990830 collagen binding|extracellular region|extracellular space|proteolysis|multicellular organism development|heparin binding|peptidase activator activity|extracellular exosome|cellular response to leukemia inhibitory factor PCOLCE2 116.053369671081 116.76922983309 115.337509509072 0.987738890407479 -0.0177983803046863 0.978511552609445 1 2.53497 2.29849 2.37043 2.50519 GeneID:26577,Genbank:NM_013363.3,HGNC:HGNC:8739,MIM:607064 procollagen C-endopeptidase enhancer 2 GO:0005518,GO:0008201,GO:0016504,GO:0070062,GO:1990830 collagen binding|heparin binding|peptidase activator activity|extracellular exosome|cellular response to leukemia inhibitory factor PCOTH 20.5128897798751 21.6395769252779 19.3862026344723 0.895867913749578 -0.158642057052926 0.844953878242626 1 0.497176 0.283282 0.423148 0.276918 GeneID:542767,Genbank:NM_001014442.3,HGNC:HGNC:39839,MIM:617122 Pro-X-Gly collagen triple helix like repeat containing GO:0005581,GO:0070062 collagen trimer|extracellular exosome PCP4 0.969266633120943 0 1.93853326624189 Inf Inf 0.451830900262006 1 0 0 0.114366 0.105368 GeneID:5121,Genbank:NM_006198.2,HGNC:HGNC:8742,MIM:601629 Purkinje cell protein 4 GO:0005509,GO:0005516,GO:0005634,GO:0005829,GO:0043234,GO:0045666,GO:0099004 calcium ion binding|calmodulin binding|nucleus|cytosol|protein complex|positive regulation of neuron differentiation|calmodulin dependent kinase signaling pathway PCSK1 49.69172706409 50.918382528026 48.4650716001539 0.951818757665335 -0.0712412086552935 0.893503136109245 1 0.371544 0.359591 0.347873 0.323813 GeneID:5122,Genbank:NM_000439.4,HGNC:HGNC:8743,MIM:162150 proprotein convertase subtilisin/kexin type 1 GO:0004252,GO:0005615,GO:0006508,GO:0007267,GO:0008152,GO:0016486,GO:0030133,GO:0034774,GO:0042802,GO:0043043 serine-type endopeptidase activity|extracellular space|proteolysis|cell-cell signaling|metabolic process|peptide hormone processing|transport vesicle|secretory granule lumen|identical protein binding|peptide biosynthetic process PCSK1N 168.995007953835 172.261951113002 165.728064794667 0.96207005507531 -0.0557861443120963 0.81297793886894 1 16.0897 16.9253 14.9608 18.0931 GeneID:27344,Genbank:NM_013271.4,HGNC:HGNC:17301,MIM:300399 proprotein convertase subtilisin/kexin type 1 inhibitor GO:0002021,GO:0004866,GO:0004867,GO:0005102,GO:0005615,GO:0005802,GO:0007218,GO:0009409,GO:0016486,GO:0030141,GO:0070062 response to dietary excess|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|receptor binding|extracellular space|trans-Golgi network|neuropeptide signaling pathway|response to cold|peptide hormone processing|secretory granule|extracellular exosome PCSK4 17.9735369775522 13.1740929230559 22.7729810320485 1.72861852159807 0.789619524433238 0.25833142224965 1 0.0758301 0.151781 0.193548 0.15521 GeneID:54760,Genbank:XM_011528091.2,HGNC:HGNC:8746,MIM:600487 proprotein convertase subtilisin/kexin type 4 GO:0001669,GO:0002080,GO:0004252,GO:0007339,GO:0007340,GO:0009566,GO:0016021,GO:0016485,GO:0022414,GO:0048240 acrosomal vesicle|acrosomal membrane|serine-type endopeptidase activity|binding of sperm to zona pellucida|acrosome reaction|fertilization|integral component of membrane|protein processing|reproductive process|sperm capacitation PCSK5 45.7662707101948 40.1466203400719 51.3859210803177 1.27995633617576 0.356094595649376 0.518940895792182 1 0.0729768 0.0778623 0.144154 0.0715602 GeneID:5125,Genbank:NM_001190482.1,HGNC:HGNC:8747,MIM:600488 proprotein convertase subtilisin/kexin type 5 GO:0001822,GO:0002001,GO:0003279,GO:0004175,GO:0004252,GO:0005576,GO:0005615,GO:0005794,GO:0005796,GO:0006465,GO:0007267,GO:0007368,GO:0007507,GO:0007566,GO:0008233,GO:0009952,GO:0016021,GO:0016485,GO:0016486,GO:0019058,GO:0030141,GO:0030323,GO:0032455,GO:0035108,GO:0042089,GO:0042277,GO:0043043,GO:0048566,GO:0048706,GO:0051004,GO:0060976 kidney development|renin secretion into blood stream|cardiac septum development|endopeptidase activity|serine-type endopeptidase activity|extracellular region|extracellular space|Golgi apparatus|Golgi lumen|signal peptide processing|cell-cell signaling|determination of left/right symmetry|heart development|embryo implantation|peptidase activity|anterior/posterior pattern specification|integral component of membrane|protein processing|peptide hormone processing|viral life cycle|secretory granule|respiratory tube development|nerve growth factor processing|limb morphogenesis|cytokine biosynthetic process|peptide binding|peptide biosynthetic process|embryonic digestive tract development|embryonic skeletal system development|regulation of lipoprotein lipase activity|coronary vasculature development PCSK7 1037.05401764807 989.061452994157 1085.04658230199 1.09704667896748 0.133624913236227 0.384793272980254 1 5.67793 5.54778 6.11989 6.34196 GeneID:9159,Genbank:XM_024448764.1,HGNC:HGNC:8748,MIM:604872 proprotein convertase subtilisin/kexin type 7 GO:0004252,GO:0008233,GO:0016485,GO:0016486,GO:0030173 serine-type endopeptidase activity|peptidase activity|protein processing|peptide hormone processing|integral component of Golgi membrane PCSK9 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0124826 0.0134415 0 GeneID:255738,Genbank:NM_174936.3,HGNC:HGNC:20001,MIM:607786 proprotein convertase subtilisin/kexin type 9 hsa04979 Cholesterol metabolism PCTP 325.658260511362 287.858933043438 363.457587979286 1.26262396701248 0.336425041578564 0.0869636843665285 0.967672357727583 2.75191 2.99944 3.79414 3.71886 GeneID:58488,Genbank:NM_001330378.1,HGNC:HGNC:8752,MIM:606055 phosphatidylcholine transfer protein GO:0005829,GO:0006656,GO:0006869,GO:0008525,GO:0015914,GO:0031210 cytosol|phosphatidylcholine biosynthetic process|lipid transport|phosphatidylcholine transporter activity|phospholipid transport|phosphatidylcholine binding PCYOX1 1659.43978155319 1597.39155494726 1721.48800815912 1.07768693457 0.107938139556332 0.449864648425571 1 12.5227 13.0103 14.9972 12.6913 GeneID:51449,Genbank:NM_016297.3,HGNC:HGNC:20588,MIM:610995 prenylcysteine oxidase 1 GO:0001735,GO:0005764,GO:0005774,GO:0005886,GO:0008555,GO:0030327,GO:0030328,GO:0030329,GO:0034361,GO:0070062 prenylcysteine oxidase activity|lysosome|vacuolar membrane|plasma membrane|chloride-transporting ATPase activity|prenylated protein catabolic process|prenylcysteine catabolic process|prenylcysteine metabolic process|very-low-density lipoprotein particle|extracellular exosome hsa00900 Terpenoid backbone biosynthesis PCYOX1L 371.522868858944 332.050586113007 410.995151604882 1.23774861058371 0.307718329825128 0.0989221803426365 1 3.1754 3.10154 4.39228 3.50828 GeneID:78991,Genbank:NM_001301054.1,HGNC:HGNC:28477 prenylcysteine oxidase 1 like GO:0001735,GO:0002576,GO:0005576,GO:0005774,GO:0016020,GO:0030327,GO:0030328,GO:0031093 prenylcysteine oxidase activity|platelet degranulation|extracellular region|vacuolar membrane|membrane|prenylated protein catabolic process|prenylcysteine catabolic process|platelet alpha granule lumen PCYT1A 2258.52964102038 2274.65701144122 2242.40227059954 0.985819954094423 -0.0206039118273759 0.892096113832077 1 30.0632 30.3457 30.9958 28.9246 GeneID:5130,Genbank:NM_001312673.1,HGNC:HGNC:8754,MIM:123695 phosphate cytidylyltransferase 1, choline, alpha hsa00440,hsa00564,hsa05231 Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Choline metabolism in cancer PCYT1B 206.010187773113 183.715889801654 228.304485744572 1.24270407960388 0.313482793804149 0.366310669624278 1 0.946856 1.08298 1.60011 0.962727 GeneID:9468,Genbank:NM_001163264.1,HGNC:HGNC:8755,MIM:300948 phosphate cytidylyltransferase 1, choline, beta hsa00440,hsa00564,hsa05231 Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Choline metabolism in cancer PCYT2 1341.77316116412 1257.28134634143 1426.2649759868 1.13440399011494 0.181934512186635 0.233731782579097 1 7.26518 8.38625 9.41206 8.90876 GeneID:5833,Genbank:XM_006722287.4,HGNC:HGNC:8756,MIM:602679 phosphate cytidylyltransferase 2, ethanolamine GO:0004306,GO:0005789,GO:0006646,GO:0008654 ethanolamine-phosphate cytidylyltransferase activity|endoplasmic reticulum membrane|phosphatidylethanolamine biosynthetic process|phospholipid biosynthetic process hsa00440,hsa00564 Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism PDAP1 7305.8554756069 7279.86967431124 7331.84127690256 1.00713908420294 0.0102629308462593 0.948895603179649 1 86.59 90.136 90.6592 88.2842 GeneID:11333,Genbank:NM_014891.6,HGNC:HGNC:14634,MIM:607075 PDGFA associated protein 1 GO:0003723,GO:0005576,GO:0005829,GO:0005886,GO:0007165,GO:0008283,GO:0043312,GO:1904813 RNA binding|extracellular region|cytosol|plasma membrane|signal transduction|cell proliferation|neutrophil degranulation|ficolin-1-rich granule lumen PDCD10 757.447627744636 819.892800771207 695.002454718066 0.847674786343206 -0.238417219391949 0.141271503698758 1 9.10138 8.61454 8.06691 6.71883 GeneID:11235,Genbank:XM_017005645.2,HGNC:HGNC:8761,MIM:609118 programmed cell death 10 GO:0000139,GO:0001525,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0008284,GO:0010628,GO:0010629,GO:0019901,GO:0030335,GO:0032874,GO:0033138,GO:0036481,GO:0042542,GO:0042803,GO:0043066,GO:0043406,GO:0044319,GO:0045747,GO:0047485,GO:0050821,GO:0051683,GO:0070062,GO:0071902,GO:0090051,GO:0090168,GO:0090316,GO:1903588,GO:1990830 Golgi membrane|angiogenesis|cytoplasm|Golgi apparatus|cytosol|plasma membrane|positive regulation of cell proliferation|positive regulation of gene expression|negative regulation of gene expression|protein kinase binding|positive regulation of cell migration|positive regulation of stress-activated MAPK cascade|positive regulation of peptidyl-serine phosphorylation|intrinsic apoptotic signaling pathway in response to hydrogen peroxide|response to hydrogen peroxide|protein homodimerization activity|negative regulation of apoptotic process|positive regulation of MAP kinase activity|wound healing, spreading of cells|positive regulation of Notch signaling pathway|protein N-terminus binding|protein stabilization|establishment of Golgi localization|extracellular exosome|positive regulation of protein serine/threonine kinase activity|negative regulation of cell migration involved in sprouting angiogenesis|Golgi reassembly|positive regulation of intracellular protein transport|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|cellular response to leukemia inhibitory factor PDCD11 2636.08577983591 2747.2424200564 2524.92913961542 0.919077661724361 -0.121741321021901 0.370568258292922 1 12.0338 12.5903 11.8574 11.1193 GeneID:22984,Genbank:XM_005269647.3,HGNC:HGNC:13408,MIM:612333 programmed cell death 11 GO:0000462,GO:0000466,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0006397,GO:0008134,GO:0032040 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleoplasm|nucleolus|cytosol|rRNA processing|mRNA processing|transcription factor binding|small-subunit processome PDCD1LG2 114.351107500389 122.554034107208 106.148180893571 0.866133715359499 -0.207338326754841 0.467092548912495 1 1.65769 1.72613 1.70125 1.1065 GeneID:80380,Genbank:XM_005251600.3,HGNC:HGNC:18731,MIM:605723 programmed cell death 1 ligand 2 GO:0005886,GO:0006955,GO:0012505,GO:0016021,GO:0031295,GO:0032689,GO:0032693,GO:0042102,GO:0046007,GO:0070062 plasma membrane|immune response|endomembrane system|integral component of membrane|T cell costimulation|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|positive regulation of T cell proliferation|negative regulation of activated T cell proliferation|extracellular exosome hsa04514 Cell adhesion molecules (CAMs) PDCD2 1898.08394470586 1975.00897278719 1821.15891662454 0.922101591292755 -0.117002388505911 0.407140290302384 1 12.1241 13.1972 11.5348 12.0176 GeneID:5134,Genbank:NM_002598.3,HGNC:HGNC:8762,MIM:600866 programmed cell death 2 GO:0003677,GO:0005634,GO:0005737,GO:0006915,GO:0006919,GO:0019899,GO:0043065,GO:0046872,GO:0070062,GO:1901532,GO:1902035 DNA binding|nucleus|cytoplasm|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|enzyme binding|positive regulation of apoptotic process|metal ion binding|extracellular exosome|regulation of hematopoietic progenitor cell differentiation|positive regulation of hematopoietic stem cell proliferation PDCD2L 359.404873294227 417.850282074268 300.959464514186 0.720256698213008 -0.473416922725048 0.0124587981290203 0.457174277026815 18.9756 18.302 14.8412 13.1505 GeneID:84306,Genbank:NM_032346.1,HGNC:HGNC:28194,MIM:615661 programmed cell death 2 like GO:0005737,GO:0007049,GO:0016020 cytoplasm|cell cycle|membrane PDCD4 217.94651195743 233.326737257223 202.566286657636 0.868165770622009 -0.203957552655215 0.388789366183977 1 2.50545 2.19747 2.03576 2.10055 GeneID:27250,Genbank:NM_145341.3,HGNC:HGNC:8763,MIM:608610 programmed cell death 4 hsa05205,hsa05206 Proteoglycans in cancer|MicroRNAs in cancer PDCD5 1586.15116276858 1755.75698501522 1416.54534052194 0.806800344587355 -0.309716394756069 0.033474938322805 0.722752120505173 23.0046 20.2235 17.5259 17.5674 GeneID:9141,Genbank:NM_004708.3,HGNC:HGNC:8764,MIM:604583 programmed cell death 5 GO:0003677,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0008201,GO:0008285,GO:0010628,GO:0010698,GO:0043065,GO:0043280,GO:0048487,GO:0070062,GO:0071560,GO:0090200,GO:1903638,GO:1903645 DNA binding|nucleus|cytoplasm|cytosol|apoptotic process|heparin binding|negative regulation of cell proliferation|positive regulation of gene expression|acetyltransferase activator activity|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|beta-tubulin binding|extracellular exosome|cellular response to transforming growth factor beta stimulus|positive regulation of release of cytochrome c from mitochondria|positive regulation of protein import into mitochondrial outer membrane|negative regulation of chaperone-mediated protein folding PDCD6 1330.18166623276 1257.00096334672 1403.3623691188 1.1164369877509 0.158901827045141 0.352888869746625 1 58.3853 59.3259 62.1718 71.9351 GeneID:10016,Genbank:NM_013232.3,HGNC:HGNC:8765,MIM:601057 programmed cell death 6 PDCD6IP 1953.34827133991 2011.59758079716 1895.09896188266 0.942086518682164 -0.0860685357478635 0.657363236892751 1 11.4604 10.4575 11.9104 8.82031 GeneID:10015,Genbank:NM_001162429.2,HGNC:HGNC:8766,MIM:608074 programmed cell death 6 interacting protein GO:0000281,GO:0000915,GO:0000920,GO:0001772,GO:0005815,GO:0005829,GO:0005923,GO:0005925,GO:0006915,GO:0010824,GO:0015031,GO:0016020,GO:0019058,GO:0031871,GO:0036258,GO:0039702,GO:0042470,GO:0042641,GO:0042803,GO:0043209,GO:0045199,GO:0046755,GO:0048306,GO:0051260,GO:0070062,GO:0070830,GO:0070971,GO:0090543,GO:0090559,GO:0090611,GO:1903543,GO:1903551,GO:1903553,GO:1903561 mitotic cytokinesis|actomyosin contractile ring assembly|cell separation after cytokinesis|immunological synapse|microtubule organizing center|cytosol|bicellular tight junction|focal adhesion|apoptotic process|regulation of centrosome duplication|protein transport|membrane|viral life cycle|proteinase activated receptor binding|multivesicular body assembly|viral budding via host ESCRT complex|melanosome|actomyosin|protein homodimerization activity|myelin sheath|maintenance of epithelial cell apical/basal polarity|viral budding|calcium-dependent protein binding|protein homooligomerization|extracellular exosome|bicellular tight junction assembly|endoplasmic reticulum exit site|Flemming body|regulation of membrane permeability|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|positive regulation of exosomal secretion|regulation of extracellular exosome assembly|positive regulation of extracellular exosome assembly|extracellular vesicle hsa04144 Endocytosis PDCD7 647.298816821843 610.780458962887 683.817174680798 1.11957932616562 0.162956751871884 0.314366930164691 1 10.471 9.56062 11.851 10.8951 GeneID:10081,Genbank:NM_005707.1,HGNC:HGNC:8767,MIM:608138 programmed cell death 7 GO:0000398,GO:0005654,GO:0005689,GO:0006915,GO:0008380,GO:0051384 mRNA splicing, via spliceosome|nucleoplasm|U12-type spliceosomal complex|apoptotic process|RNA splicing|response to glucocorticoid PDCL 744.271522028031 787.259930593911 701.28311346215 0.890789796621683 -0.166843061736518 0.315640639485401 1 7.99747 7.09497 7.2239 6.31365 GeneID:5082,Genbank:XM_017014785.1,HGNC:HGNC:8770,MIM:604421 phosducin like GO:0005057,GO:0005737,GO:0005829,GO:0006457,GO:0007165,GO:0007601,GO:0008277,GO:0008616,GO:0032403,GO:0061084,GO:1902605 signal transducer activity, downstream of receptor|cytoplasm|cytosol|protein folding|signal transduction|visual perception|regulation of G-protein coupled receptor protein signaling pathway|queuosine biosynthetic process|protein complex binding|negative regulation of protein refolding|heterotrimeric G-protein complex assembly PDCL2 1.02229600717608 1.07619535328461 0.968396661067546 0.899833527539349 -0.152269972565186 1 1 0.0803888 0 0 0.0358757 GeneID:132954,Genbank:XM_005265728.3,HGNC:HGNC:29524,MIM:611676 phosducin like 2 GO:0005737,GO:0008616 cytoplasm|queuosine biosynthetic process PDCL3 556.848681206578 564.118831573314 549.578530839842 0.974224755637176 -0.0376734514942435 0.846698628651254 1 9.19152 8.59105 9.60196 8.76347 GeneID:79031,Genbank:NM_024065.4,HGNC:HGNC:28860,MIM:611678 phosducin like 3 GO:0001525,GO:0001938,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0008616,GO:0016032,GO:0043184,GO:0044183,GO:0045766,GO:0050730,GO:2000059 angiogenesis|positive regulation of endothelial cell proliferation|nucleus|cytoplasm|cytosol|apoptotic process|queuosine biosynthetic process|viral process|vascular endothelial growth factor receptor 2 binding|protein binding involved in protein folding|positive regulation of angiogenesis|regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process PDE10A 43.8368607644451 37.2640268581206 50.4096946707696 1.35277099446874 0.435917631548344 0.326890122239914 1 0.0753701 0.0903293 0.119076 0.0748786 GeneID:10846,Genbank:XM_011535387.3,HGNC:HGNC:8772,MIM:610652 phosphodiesterase 10A GO:0004114,GO:0004115,GO:0004118,GO:0005829,GO:0006198,GO:0007186,GO:0008144,GO:0010738,GO:0016020,GO:0030552,GO:0030553,GO:0043204,GO:0043949,GO:0046069,GO:0046872,GO:0047555 3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|cytosol|cAMP catabolic process|G-protein coupled receptor signaling pathway|drug binding|regulation of protein kinase A signaling|membrane|cAMP binding|cGMP binding|perikaryon|regulation of cAMP-mediated signaling|cGMP catabolic process|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity hsa00230,hsa04024,hsa05032 Purine metabolism|cAMP signaling pathway|Morphine addiction PDE11A 0.974704718517834 0.980142803914724 0.969266633120943 0.98890348350226 -0.0160983733645535 1 1 0 0.00782377 0 0.00368044 GeneID:50940,Genbank:NM_001077197.1,HGNC:HGNC:8773,MIM:604961 phosphodiesterase 11A hsa00230,hsa04934,hsa05032 Purine metabolism|Cushing syndrome|Morphine addiction PDE12 1087.1761606786 1093.58870643342 1080.76361492377 0.988272472608579 -0.0170192386169902 0.909085369868983 1 6.40067 6.82312 7.11814 6.16009 GeneID:201626,Genbank:NM_001322176.1,HGNC:HGNC:25386,MIM:616519 phosphodiesterase 12 GO:0000175,GO:0000288,GO:0000958,GO:0004527,GO:0004535,GO:0005759,GO:0006397,GO:0035457,GO:0044528,GO:0045070,GO:0046872,GO:0060548,GO:0071346,GO:0071359,GO:0090305,GO:0090324,GO:0090503 3'-5'-exoribonuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|mitochondrial mRNA catabolic process|exonuclease activity|poly(A)-specific ribonuclease activity|mitochondrial matrix|mRNA processing|cellular response to interferon-alpha|regulation of mitochondrial mRNA stability|positive regulation of viral genome replication|metal ion binding|negative regulation of cell death|cellular response to interferon-gamma|cellular response to dsRNA|nucleic acid phosphodiester bond hydrolysis|negative regulation of oxidative phosphorylation|RNA phosphodiester bond hydrolysis, exonucleolytic PDE1A 1.02566752891457 1.56626675524197 0.48506830258717 0.309697119576692 -1.69107012999473 0.789536483244536 1 0.00840058 0.00412128 0.0040801 0 GeneID:5136,Genbank:NM_001258312.1,HGNC:HGNC:8774,MIM:171890 phosphodiesterase 1A GO:0004115,GO:0004117,GO:0005516,GO:0005634,GO:0005829,GO:0006198,GO:0007186,GO:0030553,GO:0034391,GO:0043025,GO:0046069,GO:0046872,GO:0047555,GO:0048101,GO:0048660 3',5'-cyclic-AMP phosphodiesterase activity|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|calmodulin binding|nucleus|cytosol|cAMP catabolic process|G-protein coupled receptor signaling pathway|cGMP binding|regulation of smooth muscle cell apoptotic process|neuronal cell body|cGMP catabolic process|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity|calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity|regulation of smooth muscle cell proliferation hsa00230,hsa04020,hsa04740,hsa04742,hsa04924,hsa05032 Purine metabolism|Calcium signaling pathway|Olfactory transduction|Taste transduction|Renin secretion|Morphine addiction PDE1B 1.02273099320278 1.07619535328461 0.969266633120943 0.900641904987498 -0.150974490057726 1 1 0.0185591 0 0.0086778 0.00810554 GeneID:5153,Genbank:NM_001288768.1,HGNC:HGNC:8775,MIM:171891 phosphodiesterase 1B GO:0001975,GO:0004115,GO:0004117,GO:0005516,GO:0005829,GO:0006198,GO:0006915,GO:0007186,GO:0007626,GO:0008542,GO:0030224,GO:0036006,GO:0042053,GO:0042428,GO:0043025,GO:0046069,GO:0046872,GO:0047555,GO:0048101,GO:0097011 response to amphetamine|3',5'-cyclic-AMP phosphodiesterase activity|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|calmodulin binding|cytosol|cAMP catabolic process|apoptotic process|G-protein coupled receptor signaling pathway|locomotory behavior|visual learning|monocyte differentiation|cellular response to macrophage colony-stimulating factor stimulus|regulation of dopamine metabolic process|serotonin metabolic process|neuronal cell body|cGMP catabolic process|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity|calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity|cellular response to granulocyte macrophage colony-stimulating factor stimulus hsa00230,hsa04020,hsa04740,hsa04742,hsa04924,hsa05032 Purine metabolism|Calcium signaling pathway|Olfactory transduction|Taste transduction|Renin secretion|Morphine addiction PDE1C 6224.62629720535 6182.43748754873 6266.81510686197 1.01364795349458 0.0195566819910965 0.880428674612625 1 17.1541 15.9061 18.8792 14.4224 GeneID:5137,Genbank:NM_001191058.3,HGNC:HGNC:8776,MIM:602987 phosphodiesterase 1C GO:0004117,GO:0005516,GO:0005829,GO:0007165,GO:0046872 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|calmodulin binding|cytosol|signal transduction|metal ion binding hsa00230,hsa04020,hsa04740,hsa04742,hsa04924,hsa05032 Purine metabolism|Calcium signaling pathway|Olfactory transduction|Taste transduction|Renin secretion|Morphine addiction PDE2A 12.7694875920514 13.904295698438 11.6346794856649 0.836768703572088 -0.257099201292108 0.796281716128033 1 0.124334 0.0622451 0.0993947 0.0540662 GeneID:5138,Genbank:NM_002599.4,HGNC:HGNC:8777,MIM:602658 phosphodiesterase 2A GO:0000122,GO:0004112,GO:0004115,GO:0004118,GO:0005262,GO:0005634,GO:0005737,GO:0005741,GO:0005743,GO:0005759,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0006198,GO:0006626,GO:0007186,GO:0008144,GO:0008152,GO:0019933,GO:0019934,GO:0030224,GO:0030552,GO:0030553,GO:0030911,GO:0033159,GO:0035690,GO:0036006,GO:0042734,GO:0042802,GO:0042803,GO:0043116,GO:0043117,GO:0046069,GO:0046872,GO:0047555,GO:0048471,GO:0050729,GO:0061028,GO:0071260,GO:0071321,GO:0071560,GO:0097011 negative regulation of transcription from RNA polymerase II promoter|cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|calcium channel activity|nucleus|cytoplasm|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial matrix|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|cAMP catabolic process|protein targeting to mitochondrion|G-protein coupled receptor signaling pathway|drug binding|metabolic process|cAMP-mediated signaling|cGMP-mediated signaling|monocyte differentiation|cAMP binding|cGMP binding|TPR domain binding|negative regulation of protein import into nucleus, translocation|cellular response to drug|cellular response to macrophage colony-stimulating factor stimulus|presynaptic membrane|identical protein binding|protein homodimerization activity|negative regulation of vascular permeability|positive regulation of vascular permeability|cGMP catabolic process|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity|perinuclear region of cytoplasm|positive regulation of inflammatory response|establishment of endothelial barrier|cellular response to mechanical stimulus|cellular response to cGMP|cellular response to transforming growth factor beta stimulus|cellular response to granulocyte macrophage colony-stimulating factor stimulus hsa00230,hsa04022,hsa04740,hsa04925,hsa05032 Purine metabolism|cGMP-PKG signaling pathway|Olfactory transduction|Aldosterone synthesis and secretion|Morphine addiction PDE3A 8.01005784293481 7.29323609956755 8.72687958630208 1.19657165449772 0.258906792608325 0.84337305794016 1 0.0353679 0.0159276 0.0500752 0.0171768 GeneID:5139,Genbank:NM_000921.4,HGNC:HGNC:8778,MIM:123805 phosphodiesterase 3A hsa00230,hsa04022,hsa04024,hsa04924,hsa05032 Purine metabolism|cGMP-PKG signaling pathway|cAMP signaling pathway|Renin secretion|Morphine addiction PDE3B 8.95174558487828 11.1177547658566 6.7857364039 0.610351329635323 -0.712288170875584 0.473505843435426 1 0.032223 0.0673541 0.0363049 0.0289002 GeneID:5140,Genbank:XM_017017911.2,HGNC:HGNC:8779,MIM:602047 phosphodiesterase 3B GO:0001525,GO:0004114,GO:0004115,GO:0004119,GO:0005783,GO:0005794,GO:0005829,GO:0006198,GO:0007162,GO:0007186,GO:0016020,GO:0016021,GO:0016525,GO:0032045,GO:0032869,GO:0033629,GO:0043422,GO:0043951,GO:0046872,GO:0047555,GO:0050995 angiogenesis|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|endoplasmic reticulum|Golgi apparatus|cytosol|cAMP catabolic process|negative regulation of cell adhesion|G-protein coupled receptor signaling pathway|membrane|integral component of membrane|negative regulation of angiogenesis|guanyl-nucleotide exchange factor complex|cellular response to insulin stimulus|negative regulation of cell adhesion mediated by integrin|protein kinase B binding|negative regulation of cAMP-mediated signaling|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity|negative regulation of lipid catabolic process hsa00230,hsa04022,hsa04024,hsa04371,hsa04910,hsa04914,hsa04922,hsa04923,hsa04924,hsa05032 Purine metabolism|cGMP-PKG signaling pathway|cAMP signaling pathway|Apelin signaling pathway|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Morphine addiction PDE4A 24.9187235302177 25.1181030136644 24.7193440467709 0.984124638445963 -0.0230870518018131 1 1 0.12897 0.13206 0.178248 0.118187 GeneID:5141,Genbank:NM_001243121.1,HGNC:HGNC:8780,MIM:600126 phosphodiesterase 4A GO:0004115,GO:0005654,GO:0005829,GO:0005886,GO:0006198,GO:0007165,GO:0007186,GO:0007608,GO:0010738,GO:0016020,GO:0030552,GO:0032587,GO:0035690,GO:0043949,GO:0046872,GO:0048471 3',5'-cyclic-AMP phosphodiesterase activity|nucleoplasm|cytosol|plasma membrane|cAMP catabolic process|signal transduction|G-protein coupled receptor signaling pathway|sensory perception of smell|regulation of protein kinase A signaling|membrane|cAMP binding|ruffle membrane|cellular response to drug|regulation of cAMP-mediated signaling|metal ion binding|perinuclear region of cytoplasm hsa00230,hsa04024,hsa04928,hsa05032 Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction PDE4B 49.5968341791503 41.0307105946168 58.1629577636837 1.41754692816153 0.503396496652685 0.219777076311556 1 0.234051 0.220626 0.341658 0.254893 GeneID:5142,Genbank:NM_001037341.1,HGNC:HGNC:8781,MIM:600127 phosphodiesterase 4B GO:0000930,GO:0001780,GO:0004115,GO:0005813,GO:0005829,GO:0006198,GO:0007186,GO:0008021,GO:0014069,GO:0016020,GO:0030018,GO:0030552,GO:0030593,GO:0032729,GO:0032743,GO:0035690,GO:0043015,GO:0043197,GO:0044325,GO:0046872,GO:0050852,GO:0050900,GO:0060076,GO:0071222,GO:0071872,GO:0071944,GO:0086004,GO:1901841,GO:1901898 gamma-tubulin complex|neutrophil homeostasis|3',5'-cyclic-AMP phosphodiesterase activity|centrosome|cytosol|cAMP catabolic process|G-protein coupled receptor signaling pathway|synaptic vesicle|postsynaptic density|membrane|Z disc|cAMP binding|neutrophil chemotaxis|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|cellular response to drug|gamma-tubulin binding|dendritic spine|ion channel binding|metal ion binding|T cell receptor signaling pathway|leukocyte migration|excitatory synapse|cellular response to lipopolysaccharide|cellular response to epinephrine stimulus|cell periphery|regulation of cardiac muscle cell contraction|regulation of high voltage-gated calcium channel activity|negative regulation of relaxation of cardiac muscle hsa00230,hsa04024,hsa04928,hsa05032 Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction PDE4C 1.7759781620577 1.61429302992691 1.93766329418849 1.2003169550179 0.263415413378825 1 1 0.014353 0 0.00669811 0.00624865 GeneID:5143,Genbank:NM_000923.5,HGNC:HGNC:8782,MIM:600128 phosphodiesterase 4C GO:0004115,GO:0005615,GO:0005829,GO:0005929,GO:0006198,GO:0007186,GO:0046872 3',5'-cyclic-AMP phosphodiesterase activity|extracellular space|cytosol|cilium|cAMP catabolic process|G-protein coupled receptor signaling pathway|metal ion binding hsa00230,hsa04024,hsa04928,hsa05032 Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction PDE4D 152.440014182368 184.666606640245 120.213421724492 0.650975419495762 -0.619325025906705 0.0694425045771986 0.918407228165493 0.477985 0.394026 0.353677 0.21216 GeneID:5144,Genbank:XM_024446112.1,HGNC:HGNC:8783,MIM:600129 phosphodiesterase 4D GO:0002027,GO:0004115,GO:0005813,GO:0005829,GO:0006198,GO:0006939,GO:0007568,GO:0008144,GO:0010880,GO:0016324,GO:0030552,GO:0030593,GO:0030814,GO:0031965,GO:0032729,GO:0032743,GO:0032754,GO:0033137,GO:0034704,GO:0035264,GO:0044325,GO:0045822,GO:0046872,GO:0050852,GO:0050900,GO:0051117,GO:0060314,GO:0061028,GO:0071222,GO:0071872,GO:0086004,GO:0097110,GO:1901844,GO:1901898 regulation of heart rate|3',5'-cyclic-AMP phosphodiesterase activity|centrosome|cytosol|cAMP catabolic process|smooth muscle contraction|aging|drug binding|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|apical plasma membrane|cAMP binding|neutrophil chemotaxis|regulation of cAMP metabolic process|nuclear membrane|positive regulation of interferon-gamma production|positive regulation of interleukin-2 production|positive regulation of interleukin-5 production|negative regulation of peptidyl-serine phosphorylation|calcium channel complex|multicellular organism growth|ion channel binding|negative regulation of heart contraction|metal ion binding|T cell receptor signaling pathway|leukocyte migration|ATPase binding|regulation of ryanodine-sensitive calcium-release channel activity|establishment of endothelial barrier|cellular response to lipopolysaccharide|cellular response to epinephrine stimulus|regulation of cardiac muscle cell contraction|scaffold protein binding|regulation of cell communication by electrical coupling involved in cardiac conduction|negative regulation of relaxation of cardiac muscle hsa00230,hsa04024,hsa04928,hsa05032 Purine metabolism|cAMP signaling pathway|Parathyroid hormone synthesis, secretion and action|Morphine addiction PDE4DIP 1538.42670650962 1522.54693461844 1554.3064784008 1.02085948423673 0.0297843007446671 0.841422551901261 1 3.11439 3.19484 3.605 2.96931 GeneID:9659,Genbank:NM_001350521.1,HGNC:HGNC:15580,MIM:608117 phosphodiesterase 4D interacting protein PDE5A 19.4093226737043 23.7919676318472 15.0266777155615 0.631586170092434 -0.662948514185585 0.32276871015147 1 0.120967 0.0644607 0.0643475 0.0543507 GeneID:8654,Genbank:NM_001083.3,HGNC:HGNC:8784,MIM:603310 phosphodiesterase 5A GO:0004114,GO:0005829,GO:0007165,GO:0010613,GO:0030553,GO:0030823,GO:0042130,GO:0043406,GO:0046069,GO:0046872,GO:0047555,GO:0055118,GO:0055119,GO:0060282 3',5'-cyclic-nucleotide phosphodiesterase activity|cytosol|signal transduction|positive regulation of cardiac muscle hypertrophy|cGMP binding|regulation of cGMP metabolic process|negative regulation of T cell proliferation|positive regulation of MAP kinase activity|cGMP catabolic process|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity|negative regulation of cardiac muscle contraction|relaxation of cardiac muscle|positive regulation of oocyte development hsa00230,hsa04022 Purine metabolism|cGMP-PKG signaling pathway PDE6A 3.82937978354524 5.23689794236822 2.42186162472226 0.46246110796405 -1.11259605186743 0.541693294658059 1 0.0267729 0.00998336 0.00510718 0.0142526 GeneID:5145,Genbank:NM_000440.2,HGNC:HGNC:8785,MIM:180071 phosphodiesterase 6A hsa00230,hsa04744 Purine metabolism|Phototransduction PDE6B 0.969266633120943 0 1.93853326624189 Inf Inf 0.451830900262006 1 0 0 0.0107594 0.0100456 GeneID:5158,Genbank:XM_011513474.3,HGNC:HGNC:8786,MIM:180072 phosphodiesterase 6B hsa00230,hsa04744 Purine metabolism|Phototransduction PDE6D 532.270305585549 546.9487491963 517.591861974797 0.946326073028523 -0.0795907201117499 0.625509571994745 1 9.32605 10.9953 10.2458 9.23327 GeneID:5147,Genbank:NM_001291018.1,HGNC:HGNC:8788,MIM:602676 phosphodiesterase 6D GO:0004114,GO:0005095,GO:0005829,GO:0005856,GO:0005929,GO:0007601,GO:0017137,GO:0030659,GO:0031410,GO:0050896 3',5'-cyclic-nucleotide phosphodiesterase activity|GTPase inhibitor activity|cytosol|cytoskeleton|cilium|visual perception|Rab GTPase binding|cytoplasmic vesicle membrane|cytoplasmic vesicle|response to stimulus hsa00230 Purine metabolism PDE6G 5.45801596628472 5.58289052027075 5.33314141229868 0.955265268579911 -0.0660266826568651 1 1 0.0722976 0.112485 0.0674311 0.0316145 GeneID:5148,Genbank:XM_017024734.1,HGNC:HGNC:8789,MIM:180073 phosphodiesterase 6G hsa00230,hsa04744 Purine metabolism|Phototransduction PDE7A 152.268551324436 156.713936419314 147.823166229558 0.943267520471394 -0.0842611026482185 0.771035580929484 1 0.914043 0.746035 0.904542 0.745724 GeneID:5150,Genbank:NM_001242318.2,HGNC:HGNC:8791,MIM:171885 phosphodiesterase 7A GO:0004115,GO:0005829,GO:0006198,GO:0007186,GO:0046872 3',5'-cyclic-AMP phosphodiesterase activity|cytosol|cAMP catabolic process|G-protein coupled receptor signaling pathway|metal ion binding hsa00230,hsa05032 Purine metabolism|Morphine addiction PDE7B 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0163018 0 GeneID:27115,Genbank:NM_018945.3,HGNC:HGNC:8792,MIM:604645 phosphodiesterase 7B GO:0004115,GO:0005829,GO:0006198,GO:0007165,GO:0007186,GO:0007268,GO:0046872 3',5'-cyclic-AMP phosphodiesterase activity|cytosol|cAMP catabolic process|signal transduction|G-protein coupled receptor signaling pathway|chemical synaptic transmission|metal ion binding hsa00230,hsa05032 Purine metabolism|Morphine addiction PDE8A 1208.87979373989 1132.42677470018 1285.3328127796 1.13502509963163 0.182724201228703 0.21955811539071 1 6.89541 6.00564 8.21578 6.66619 GeneID:5151,Genbank:NM_001243137.1,HGNC:HGNC:8793,MIM:602972 phosphodiesterase 8A GO:0001934,GO:0004114,GO:0004115,GO:0005829,GO:0006198,GO:0006355,GO:0007186,GO:0009187,GO:0019900,GO:0046872,GO:0060548,GO:0070062,GO:0070374,GO:0071364,GO:1903206 positive regulation of protein phosphorylation|3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cytosol|cAMP catabolic process|regulation of transcription, DNA-templated|G-protein coupled receptor signaling pathway|cyclic nucleotide metabolic process|kinase binding|metal ion binding|negative regulation of cell death|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to epidermal growth factor stimulus|negative regulation of hydrogen peroxide-induced cell death hsa00230,hsa04927,hsa04934,hsa05032 Purine metabolism|Cortisol synthesis and secretion|Cushing syndrome|Morphine addiction PDE8B 26.8837714834871 25.6562006903067 28.1113422766675 1.09569388764909 0.131844797883128 0.841531740167032 1 0.171444 0.173063 0.217202 0.144402 GeneID:8622,Genbank:XM_005248623.4,HGNC:HGNC:8794,MIM:603390 phosphodiesterase 8B GO:0004114,GO:0004115,GO:0005829,GO:0006198,GO:0007186,GO:0009187,GO:0046676,GO:0046872 3',5'-cyclic-nucleotide phosphodiesterase activity|3',5'-cyclic-AMP phosphodiesterase activity|cytosol|cAMP catabolic process|G-protein coupled receptor signaling pathway|cyclic nucleotide metabolic process|negative regulation of insulin secretion|metal ion binding hsa00230,hsa04927,hsa04934,hsa05032 Purine metabolism|Cortisol synthesis and secretion|Cushing syndrome|Morphine addiction PDE9A 187.809589781046 187.088554685562 188.530624876531 1.00770795516269 0.0110775905383461 0.97910556245632 1 0.767616 0.795462 0.676613 0.662947 GeneID:5152,Genbank:NM_001315533.1,HGNC:HGNC:8795,MIM:602973 phosphodiesterase 9A GO:0004114,GO:0005783,GO:0005794,GO:0005829,GO:0007165,GO:0010613,GO:0019934,GO:0032587,GO:0042383,GO:0042802,GO:0043204,GO:0046068,GO:0046069,GO:0046872,GO:0047555,GO:0048471 3',5'-cyclic-nucleotide phosphodiesterase activity|endoplasmic reticulum|Golgi apparatus|cytosol|signal transduction|positive regulation of cardiac muscle hypertrophy|cGMP-mediated signaling|ruffle membrane|sarcolemma|identical protein binding|perikaryon|cGMP metabolic process|cGMP catabolic process|metal ion binding|3',5'-cyclic-GMP phosphodiesterase activity|perinuclear region of cytoplasm hsa00230 Purine metabolism PDF 132.481436397304 134.603905402294 130.358967392313 0.968463485533392 -0.0462304396912336 0.866286262170914 1 30.7894 30.1208 32.7023 31.2191 GeneID:64146,Genbank:NM_022341.1,HGNC:HGNC:30012 peptide deformylase, mitochondrial GO:0005739,GO:0006412,GO:0008284,GO:0018206,GO:0031365,GO:0042586,GO:0043686,GO:0046872 mitochondrion|translation|positive regulation of cell proliferation|peptidyl-methionine modification|N-terminal protein amino acid modification|peptide deformylase activity|co-translational protein modification|metal ion binding PDGFA 230.78017373575 274.992615078707 186.567732392794 0.678446336965795 -0.559693387504198 0.00930233703326543 0.378137639402993 3.40451 3.40866 2.36524 2.16035 GeneID:5154,Genbank:XM_017012289.1,HGNC:HGNC:8799,MIM:173430 platelet derived growth factor subunit A GO:0000139,GO:0000165,GO:0001525,GO:0001775,GO:0001942,GO:0002053,GO:0002576,GO:0005088,GO:0005161,GO:0005518,GO:0005576,GO:0005615,GO:0005788,GO:0005796,GO:0005902,GO:0007267,GO:0008083,GO:0008284,GO:0009611,GO:0009887,GO:0009986,GO:0010512,GO:0010544,GO:0014068,GO:0014910,GO:0030031,GO:0030036,GO:0030198,GO:0030335,GO:0031093,GO:0031954,GO:0032956,GO:0035793,GO:0042060,GO:0042802,GO:0042803,GO:0043406,GO:0043410,GO:0043588,GO:0045740,GO:0046934,GO:0046982,GO:0048008,GO:0048146,GO:0048286,GO:0048407,GO:0050730,GO:0050919,GO:0051781,GO:0051897,GO:0060683,GO:0070374,GO:1990401,GO:2000587 Golgi membrane|MAPK cascade|angiogenesis|cell activation|hair follicle development|positive regulation of mesenchymal cell proliferation|platelet degranulation|Ras guanyl-nucleotide exchange factor activity|platelet-derived growth factor receptor binding|collagen binding|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi lumen|microvillus|cell-cell signaling|growth factor activity|positive regulation of cell proliferation|response to wounding|animal organ morphogenesis|cell surface|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of smooth muscle cell migration|cell projection assembly|actin cytoskeleton organization|extracellular matrix organization|positive regulation of cell migration|platelet alpha granule lumen|positive regulation of protein autophosphorylation|regulation of actin cytoskeleton organization|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|wound healing|identical protein binding|protein homodimerization activity|positive regulation of MAP kinase activity|positive regulation of MAPK cascade|skin development|positive regulation of DNA replication|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein heterodimerization activity|platelet-derived growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|lung alveolus development|platelet-derived growth factor binding|regulation of peptidyl-tyrosine phosphorylation|negative chemotaxis|positive regulation of cell division|positive regulation of protein kinase B signaling|regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling|positive regulation of ERK1 and ERK2 cascade|embryonic lung development|negative regulation of platelet-derived growth factor receptor-beta signaling pathway hsa01521,hsa04010,hsa04014,hsa04015,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05166,hsa05200,hsa05202,hsa05206,hsa05214,hsa05215,hsa05218,hsa05231,hsa05418 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Jak-STAT signaling pathway|Regulation of actin cytoskeleton|Human T-cell leukemia virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PDGFB 232.874767334625 318.454065372895 147.295469296354 0.462532858934861 -1.11237223468877 1.7712141517671e-06 0.00118199024394591 3.85387 3.72288 1.39563 2.16891 GeneID:5155,Genbank:NM_002608.3,HGNC:HGNC:8800,MIM:190040 platelet derived growth factor subunit B hsa01521,hsa04010,hsa04014,hsa04015,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05166,hsa05167,hsa05200,hsa05206,hsa05211,hsa05214,hsa05215,hsa05218,hsa05231,hsa05418 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Jak-STAT signaling pathway|Regulation of actin cytoskeleton|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|MicroRNAs in cancer|Renal cell carcinoma|Glioma|Prostate cancer|Melanoma|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PDGFC 1137.62797346999 1208.55931279124 1066.69663414875 0.882618356301558 -0.180138342735668 0.242938960963076 1 13.6283 12.5269 12.2661 10.9908 GeneID:56034,Genbank:NM_016205.2,HGNC:HGNC:8801,MIM:608452 platelet derived growth factor C GO:0000139,GO:0005161,GO:0005576,GO:0005615,GO:0005634,GO:0005788,GO:0005829,GO:0005886,GO:0007171,GO:0007417,GO:0007596,GO:0008083,GO:0009790,GO:0009887,GO:0009986,GO:0014068,GO:0030335,GO:0031954,GO:0042803,GO:0043406,GO:0045740,GO:0048008,GO:0048146,GO:0048565,GO:0050730,GO:0051781,GO:0060348,GO:0070062,GO:0070374,GO:0071230 Golgi membrane|platelet-derived growth factor receptor binding|extracellular region|extracellular space|nucleus|endoplasmic reticulum lumen|cytosol|plasma membrane|activation of transmembrane receptor protein tyrosine kinase activity|central nervous system development|blood coagulation|growth factor activity|embryo development|animal organ morphogenesis|cell surface|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of cell migration|positive regulation of protein autophosphorylation|protein homodimerization activity|positive regulation of MAP kinase activity|positive regulation of DNA replication|platelet-derived growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|digestive tract development|regulation of peptidyl-tyrosine phosphorylation|positive regulation of cell division|bone development|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to amino acid stimulus hsa01521,hsa04010,hsa04014,hsa04015,hsa04072,hsa04151,hsa04510,hsa04540,hsa04810,hsa05215,hsa05218,hsa05231 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Regulation of actin cytoskeleton|Prostate cancer|Melanoma|Choline metabolism in cancer PDGFD 337.194628984314 354.47820074346 319.911057225168 0.902484430789276 -0.148026051327276 0.579355602203685 1 3.64942 3.6206 4.05753 2.59121 GeneID:80310,Genbank:NM_033135.3,HGNC:HGNC:30620,MIM:609673 platelet derived growth factor D GO:0000139,GO:0005161,GO:0005576,GO:0005615,GO:0005788,GO:0007275,GO:0007596,GO:0008083,GO:0008284,GO:0014068,GO:0030335,GO:0031954,GO:0036120,GO:0043406,GO:0048008,GO:0048146,GO:0048661,GO:0050730,GO:0051781,GO:0070062,GO:0070301,GO:0070374,GO:0071230,GO:0071560,GO:0071673,GO:0072126,GO:2000439 Golgi membrane|platelet-derived growth factor receptor binding|extracellular region|extracellular space|endoplasmic reticulum lumen|multicellular organism development|blood coagulation|growth factor activity|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of cell migration|positive regulation of protein autophosphorylation|cellular response to platelet-derived growth factor stimulus|positive regulation of MAP kinase activity|platelet-derived growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of smooth muscle cell proliferation|regulation of peptidyl-tyrosine phosphorylation|positive regulation of cell division|extracellular exosome|cellular response to hydrogen peroxide|positive regulation of ERK1 and ERK2 cascade|cellular response to amino acid stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of smooth muscle cell chemotaxis|positive regulation of glomerular mesangial cell proliferation|positive regulation of monocyte extravasation hsa01521,hsa04010,hsa04014,hsa04015,hsa04072,hsa04151,hsa04510,hsa04540,hsa04810,hsa05215,hsa05218,hsa05231 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Regulation of actin cytoskeleton|Prostate cancer|Melanoma|Choline metabolism in cancer PDGFRA 2512.37601703329 2678.01483986401 2346.73719420256 0.876297307718327 -0.190507668439358 0.176161553224962 1 12.0175 11.1248 11.3881 9.23338 GeneID:5156,Genbank:NM_001347828.1,HGNC:HGNC:8803,MIM:173490 platelet derived growth factor receptor alpha GO:0000165,GO:0001553,GO:0001775,GO:0004672,GO:0004714,GO:0005018,GO:0005021,GO:0005088,GO:0005161,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0007204,GO:0008284,GO:0010544,GO:0010863,GO:0014068,GO:0016020,GO:0016032,GO:0018108,GO:0030054,GO:0030335,GO:0031226,GO:0034614,GO:0035790,GO:0038085,GO:0038091,GO:0042060,GO:0042803,GO:0043234,GO:0043552,GO:0045740,GO:0046777,GO:0046934,GO:0048008,GO:0048015,GO:0048146,GO:0048407,GO:0048557,GO:0048701,GO:0048704,GO:0050920,GO:0051897,GO:0055003,GO:0060326,GO:0061298,GO:0070374,GO:0070527,GO:0072277,GO:2000249,GO:2000587,GO:2000739 MAPK cascade|luteinization|cell activation|protein kinase activity|transmembrane receptor protein tyrosine kinase activity|platelet-derived growth factor alpha-receptor activity|vascular endothelial growth factor-activated receptor activity|Ras guanyl-nucleotide exchange factor activity|platelet-derived growth factor receptor binding|ATP binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|positive regulation of cytosolic calcium ion concentration|positive regulation of cell proliferation|negative regulation of platelet activation|positive regulation of phospholipase C activity|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|viral process|peptidyl-tyrosine phosphorylation|cell junction|positive regulation of cell migration|intrinsic component of plasma membrane|cellular response to reactive oxygen species|platelet-derived growth factor receptor-alpha signaling pathway|vascular endothelial growth factor binding|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway|wound healing|protein homodimerization activity|protein complex|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of DNA replication|protein autophosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|platelet-derived growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of fibroblast proliferation|platelet-derived growth factor binding|embryonic digestive tract morphogenesis|embryonic cranial skeleton morphogenesis|embryonic skeletal system morphogenesis|regulation of chemotaxis|positive regulation of protein kinase B signaling|cardiac myofibril assembly|cell chemotaxis|retina vasculature development in camera-type eye|positive regulation of ERK1 and ERK2 cascade|platelet aggregation|metanephric glomerular capillary formation|regulation of actin cytoskeleton reorganization|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|regulation of mesenchymal stem cell differentiation hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04144,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05163,hsa05166,hsa05200,hsa05206,hsa05214,hsa05215,hsa05218,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|Endocytosis|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Jak-STAT signaling pathway|Regulation of actin cytoskeleton|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Central carbon metabolism in cancer|Choline metabolism in cancer PDGFRB 59.2092816042431 64.1405017257668 54.2780614827194 0.846236933330919 -0.240866442553316 0.53281490542069 1 0.322586 0.271353 0.266741 0.261996 GeneID:5159,Genbank:NM_001355016.1,HGNC:HGNC:8804,MIM:173410 platelet derived growth factor receptor beta hsa01521,hsa04010,hsa04014,hsa04015,hsa04020,hsa04072,hsa04151,hsa04510,hsa04540,hsa04630,hsa04810,hsa05165,hsa05166,hsa05200,hsa05206,hsa05214,hsa05215,hsa05218,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Jak-STAT signaling pathway|Regulation of actin cytoskeleton|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|MicroRNAs in cancer|Glioma|Prostate cancer|Melanoma|Central carbon metabolism in cancer|Choline metabolism in cancer PDGFRL 496.033613242586 428.871984290755 563.195242194418 1.31320128808554 0.393088070126868 0.0251934210065621 0.631315976879816 7.69352 8.1561 12.0892 9.14977 GeneID:5157,Genbank:NM_006207.2,HGNC:HGNC:8805,MIM:604584 platelet derived growth factor receptor like GO:0004992,GO:0005019,GO:0005576 platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|extracellular region PDHA1 2504.35015154186 2435.78159047815 2572.91871260557 1.05630107504856 0.0790211013359286 0.559495936791051 1 22.0574 22.1015 23.6921 22.2035 GeneID:5160,Genbank:NM_001173454.1,HGNC:HGNC:8806,MIM:300502 pyruvate dehydrogenase E1 alpha 1 subunit GO:0004738,GO:0004739,GO:0005634,GO:0005730,GO:0005739,GO:0005759,GO:0006006,GO:0006086,GO:0006090,GO:0006099,GO:0010510,GO:0034604,GO:0034641,GO:0043209,GO:0045254,GO:0061732 pyruvate dehydrogenase activity|pyruvate dehydrogenase (acetyl-transferring) activity|nucleus|nucleolus|mitochondrion|mitochondrial matrix|glucose metabolic process|acetyl-CoA biosynthetic process from pyruvate|pyruvate metabolic process|tricarboxylic acid cycle|regulation of acetyl-CoA biosynthetic process from pyruvate|pyruvate dehydrogenase (NAD+) activity|cellular nitrogen compound metabolic process|myelin sheath|pyruvate dehydrogenase complex|mitochondrial acetyl-CoA biosynthetic process from pyruvate hsa00010,hsa00020,hsa00620,hsa04066,hsa04922,hsa05230 Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PDHB 3522.94913276942 3537.36532682205 3508.53293871678 0.991849191293123 -0.0118073165265365 0.935641512780553 1 97.1035 96.7993 92.9027 98.9853 GeneID:5162,Genbank:NM_001315536.1,HGNC:HGNC:8808,MIM:179060 pyruvate dehydrogenase E1 beta subunit GO:0004738,GO:0004739,GO:0005634,GO:0005654,GO:0005739,GO:0005759,GO:0006006,GO:0006086,GO:0006090,GO:0006099,GO:0010510,GO:0034641,GO:0045254,GO:0061732,GO:0070062 pyruvate dehydrogenase activity|pyruvate dehydrogenase (acetyl-transferring) activity|nucleus|nucleoplasm|mitochondrion|mitochondrial matrix|glucose metabolic process|acetyl-CoA biosynthetic process from pyruvate|pyruvate metabolic process|tricarboxylic acid cycle|regulation of acetyl-CoA biosynthetic process from pyruvate|cellular nitrogen compound metabolic process|pyruvate dehydrogenase complex|mitochondrial acetyl-CoA biosynthetic process from pyruvate|extracellular exosome hsa00010,hsa00020,hsa00620,hsa04066,hsa04922,hsa05230 Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism|HIF-1 signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PDHX 657.520928781666 755.761090699693 559.280766863638 0.740023234519588 -0.434357527118799 0.0184125507721722 0.553274696373563 10.3211 8.70539 7.59823 6.68063 GeneID:8050,Genbank:XM_011520390.1,HGNC:HGNC:21350,MIM:608769 pyruvate dehydrogenase complex component X GO:0005759,GO:0006090,GO:0010510,GO:0016746,GO:0034641,GO:0045254,GO:0061732 mitochondrial matrix|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|transferase activity, transferring acyl groups|cellular nitrogen compound metabolic process|pyruvate dehydrogenase complex|mitochondrial acetyl-CoA biosynthetic process from pyruvate hsa00010,hsa00020,hsa00620 Glycolysis / Gluconeogenesis|Citrate cycle (TCA cycle)|Pyruvate metabolism PDIA3 10261.6919868647 10165.1316059243 10358.2523678051 1.01899835332858 0.0271517201527796 0.833641991645012 1 121.669 126.192 127.411 127.208 GeneID:2923,Genbank:NM_005313.4,HGNC:HGNC:4606,MIM:602046 protein disulfide isomerase family A member 3 GO:0002474,GO:0002479,GO:0003723,GO:0003756,GO:0004197,GO:0004629,GO:0005615,GO:0005634,GO:0005783,GO:0005788,GO:0005925,GO:0006457,GO:0006606,GO:0006621,GO:0007165,GO:0009986,GO:0015036,GO:0015037,GO:0034975,GO:0034976,GO:0042470,GO:0042802,GO:0043209,GO:0045335,GO:0045454,GO:0055038,GO:0070062,GO:2001238 antigen processing and presentation of peptide antigen via MHC class I|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|RNA binding|protein disulfide isomerase activity|cysteine-type endopeptidase activity|phospholipase C activity|extracellular space|nucleus|endoplasmic reticulum|endoplasmic reticulum lumen|focal adhesion|protein folding|protein import into nucleus|protein retention in ER lumen|signal transduction|cell surface|disulfide oxidoreductase activity|peptide disulfide oxidoreductase activity|protein folding in endoplasmic reticulum|response to endoplasmic reticulum stress|melanosome|identical protein binding|myelin sheath|phagocytic vesicle|cell redox homeostasis|recycling endosome membrane|extracellular exosome|positive regulation of extrinsic apoptotic signaling pathway hsa04141,hsa04612,hsa05163,hsa05169,hsa05170 Protein processing in endoplasmic reticulum|Antigen processing and presentation|Human cytomegalovirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection PDIA4 10813.9120044269 10919.2679392915 10708.5560695622 0.980702747574215 -0.0281121751459242 0.815014575790896 1 112.197 118.348 119.736 108.488 GeneID:9601,Genbank:XM_006716185.2,HGNC:HGNC:30167 protein disulfide isomerase family A member 4 GO:0003723,GO:0003756,GO:0005615,GO:0005783,GO:0005788,GO:0006457,GO:0009306,GO:0009986,GO:0015037,GO:0034976,GO:0042470,GO:0045454,GO:0061077 RNA binding|protein disulfide isomerase activity|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|protein secretion|cell surface|peptide disulfide oxidoreductase activity|response to endoplasmic reticulum stress|melanosome|cell redox homeostasis|chaperone-mediated protein folding hsa04141,hsa04918,hsa05110 Protein processing in endoplasmic reticulum|Thyroid hormone synthesis|Vibrio cholerae infection PDIA5 497.628196825961 447.648585044297 547.607808607624 1.22329842403821 0.290776392713361 0.102568275639354 1 7.23786 8.68312 9.65549 10.4586 GeneID:10954,Genbank:NM_006810.3,HGNC:HGNC:24811,MIM:616942 protein disulfide isomerase family A member 5 GO:0003756,GO:0005788,GO:0005789,GO:0006457,GO:0015037,GO:0016491,GO:0034976,GO:0036498,GO:0045454,GO:0055114 protein disulfide isomerase activity|endoplasmic reticulum lumen|endoplasmic reticulum membrane|protein folding|peptide disulfide oxidoreductase activity|oxidoreductase activity|response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|cell redox homeostasis|oxidation-reduction process PDIA6 7663.59147773404 7627.35057125664 7699.83238421144 1.00950288206601 0.0136450294771225 0.921646257610036 1 79.9999 81.8236 85.7263 79.8992 GeneID:10130,Genbank:NM_001282705.1,HGNC:HGNC:30168,MIM:611099 protein disulfide isomerase family A member 6 GO:0003756,GO:0005615,GO:0005783,GO:0005788,GO:0005789,GO:0005793,GO:0005829,GO:0005886,GO:0006457,GO:0015037,GO:0034663,GO:0034976,GO:0036498,GO:0042470,GO:0043277,GO:0043687,GO:0044267,GO:0045454,GO:0070062 protein disulfide isomerase activity|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|protein folding|peptide disulfide oxidoreductase activity|endoplasmic reticulum chaperone complex|response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|melanosome|apoptotic cell clearance|post-translational protein modification|cellular protein metabolic process|cell redox homeostasis|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum PDIK1L 105.128335690689 112.838849962323 97.4178214190552 0.863335823181319 -0.212006242091765 0.543001586235352 1 0.891807 0.647347 0.721471 0.59368 GeneID:149420,Genbank:XM_006710381.4,HGNC:HGNC:18981,MIM:610785 PDLIM1 interacting kinase 1 like GO:0004674,GO:0005524,GO:0005654 protein serine/threonine kinase activity|ATP binding|nucleoplasm PDK1 229.144556172217 246.520447490495 211.768664853938 0.85903083095005 -0.219218183709262 0.320695826414531 1 1.5268 1.54889 1.29024 1.34987 GeneID:5163,Genbank:XM_011511343.2,HGNC:HGNC:8809,MIM:602524 pyruvate dehydrogenase kinase 1 GO:0004672,GO:0004740,GO:0005524,GO:0005634,GO:0005730,GO:0005739,GO:0005759,GO:0005967,GO:0006006,GO:0008283,GO:0008631,GO:0010510,GO:0010906,GO:0097411 protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|ATP binding|nucleus|nucleolus|mitochondrion|mitochondrial matrix|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|cell proliferation|intrinsic apoptotic signaling pathway in response to oxidative stress|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of glucose metabolic process|hypoxia-inducible factor-1alpha signaling pathway hsa04066,hsa04360,hsa05230 HIF-1 signaling pathway|Axon guidance|Central carbon metabolism in cancer PDK2 527.651489200158 493.598609967849 561.704368432467 1.13797801916228 0.18647269125448 0.283324413901537 1 4.8811 4.5305 5.69376 5.46633 GeneID:5164,Genbank:NM_001199898.1,HGNC:HGNC:8810,MIM:602525 pyruvate dehydrogenase kinase 2 GO:0004672,GO:0004740,GO:0005524,GO:0005654,GO:0005739,GO:0005759,GO:0005829,GO:0005967,GO:0006006,GO:0006111,GO:0006885,GO:0008286,GO:0010510,GO:0010565,GO:0010906,GO:0031670,GO:0034614,GO:0042593,GO:0042803,GO:0072332 protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|ATP binding|nucleoplasm|mitochondrion|mitochondrial matrix|cytosol|mitochondrial pyruvate dehydrogenase complex|glucose metabolic process|regulation of gluconeogenesis|regulation of pH|insulin receptor signaling pathway|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of cellular ketone metabolic process|regulation of glucose metabolic process|cellular response to nutrient|cellular response to reactive oxygen species|glucose homeostasis|protein homodimerization activity|intrinsic apoptotic signaling pathway by p53 class mediator PDK3 362.617501753389 309.392648764238 415.84235474254 1.34406023027205 0.426597789878438 0.024227967447401 0.623850685912499 0.993455 1.07778 1.5279 1.22728 GeneID:5165,Genbank:NM_001142386.2,HGNC:HGNC:8811,MIM:300906 pyruvate dehydrogenase kinase 3 GO:0004672,GO:0004674,GO:0004740,GO:0005524,GO:0005730,GO:0005739,GO:0005759,GO:0006006,GO:0010510,GO:0010906,GO:0018105,GO:0035357,GO:0071333,GO:0071398,GO:0097411,GO:2000377 protein kinase activity|protein serine/threonine kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|ATP binding|nucleolus|mitochondrion|mitochondrial matrix|glucose metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of glucose metabolic process|peptidyl-serine phosphorylation|peroxisome proliferator activated receptor signaling pathway|cellular response to glucose stimulus|cellular response to fatty acid|hypoxia-inducible factor-1alpha signaling pathway|regulation of reactive oxygen species metabolic process PDK4 24.0753827490379 21.4954981012231 26.6552673968526 1.2400395315955 0.310386113457073 0.618340738694628 1 0.199525 0.238066 0.29434 0.252872 GeneID:5166,Genbank:NM_002612.3,HGNC:HGNC:8812,MIM:602527 pyruvate dehydrogenase kinase 4 GO:0004672,GO:0004740,GO:0005524,GO:0005739,GO:0005743,GO:0005759,GO:0006006,GO:0006885,GO:0008286,GO:0009267,GO:0010510,GO:0010565,GO:0010906,GO:0042304,GO:0042593,GO:0042594,GO:0045124,GO:0046320,GO:0071398,GO:0072593,GO:2000811 protein kinase activity|pyruvate dehydrogenase (acetyl-transferring) kinase activity|ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|glucose metabolic process|regulation of pH|insulin receptor signaling pathway|cellular response to starvation|regulation of acetyl-CoA biosynthetic process from pyruvate|regulation of cellular ketone metabolic process|regulation of glucose metabolic process|regulation of fatty acid biosynthetic process|glucose homeostasis|response to starvation|regulation of bone resorption|regulation of fatty acid oxidation|cellular response to fatty acid|reactive oxygen species metabolic process|negative regulation of anoikis PDLIM1 35.5359657093498 44.4131841336334 26.6587472850662 0.600243999728855 -0.736379018097129 0.120096686625884 1 0.983779 1.13481 0.75213 0.458943 GeneID:9124,Genbank:NM_020992.3,HGNC:HGNC:2067,MIM:605900 PDZ and LIM domain 1 PDLIM2 897.464300461846 830.128499284228 964.800101639464 1.16222982643212 0.216895384291872 0.342447028695927 1 5.79768 6.72794 6.91073 8.06926 GeneID:64236,Genbank:NM_021630.5,HGNC:HGNC:13992,MIM:609722 PDZ and LIM domain 2 GO:0005634,GO:0005737,GO:0005856,GO:0046872,GO:0070062 nucleus|cytoplasm|cytoskeleton|metal ion binding|extracellular exosome PDLIM3 164.278254051037 165.237255351329 163.319252750745 0.988392432466242 -0.0168441300373575 0.975877804742073 1 2.09241 1.71687 1.91263 1.74196 GeneID:27295,Genbank:NM_001257963.1,HGNC:HGNC:20767,MIM:605889 PDZ and LIM domain 3 GO:0007015,GO:0007507,GO:0008092,GO:0008307,GO:0015629,GO:0030018,GO:0046872 actin filament organization|heart development|cytoskeletal protein binding|structural constituent of muscle|actin cytoskeleton|Z disc|metal ion binding PDLIM4 1329.22542419118 1366.07516357426 1292.3756848081 0.94605020226462 -0.0800113525103101 0.698210422883134 1 24.6653 27.706 23.5192 27.8808 GeneID:8572,Genbank:NM_003687.3,HGNC:HGNC:16501,MIM:603422 PDZ and LIM domain 4 GO:0001725,GO:0005634,GO:0005737,GO:0005856,GO:0019903,GO:0030027,GO:0030054,GO:0031532,GO:0031901,GO:0031905,GO:0031941,GO:0034777,GO:0042803,GO:0043197,GO:0045211,GO:0046872,GO:0048471,GO:0051393,GO:0055038,GO:0098976 stress fiber|nucleus|cytoplasm|cytoskeleton|protein phosphatase binding|lamellipodium|cell junction|actin cytoskeleton reorganization|early endosome membrane|early endosome lumen|filamentous actin|recycling endosome lumen|protein homodimerization activity|dendritic spine|postsynaptic membrane|metal ion binding|perinuclear region of cytoplasm|alpha-actinin binding|recycling endosome membrane|excitatory chemical synaptic transmission PDLIM5 975.781761592893 999.149004679704 952.414518506081 0.953225709123731 -0.0691102324012144 0.77862943003839 1 4.50578 3.87512 4.73936 3.40145 GeneID:10611,Genbank:NM_006457.4,HGNC:HGNC:17468,MIM:605904 PDZ and LIM domain 5 GO:0003779,GO:0005080,GO:0005829,GO:0005913,GO:0014069,GO:0015629,GO:0016020,GO:0042805,GO:0043005,GO:0045211,GO:0046872,GO:0047485,GO:0051963,GO:0061001,GO:0061049,GO:0098641 actin binding|protein kinase C binding|cytosol|cell-cell adherens junction|postsynaptic density|actin cytoskeleton|membrane|actinin binding|neuron projection|postsynaptic membrane|metal ion binding|protein N-terminus binding|regulation of synapse assembly|regulation of dendritic spine morphogenesis|cell growth involved in cardiac muscle cell development|cadherin binding involved in cell-cell adhesion PDLIM7 1948.29882659544 2342.01054992004 1554.58710327084 0.663783134249293 -0.591216121759225 4.10892846463897e-05 0.0129901067617888 36.6712 38.5325 23.5412 25.4001 GeneID:9260,Genbank:NM_203352.2,HGNC:HGNC:22958,MIM:605903 PDZ and LIM domain 7 GO:0001503,GO:0001725,GO:0001726,GO:0005634,GO:0005829,GO:0005913,GO:0005925,GO:0006898,GO:0007411,GO:0015629,GO:0030036,GO:0045669,GO:0046872 ossification|stress fiber|ruffle|nucleus|cytosol|cell-cell adherens junction|focal adhesion|receptor-mediated endocytosis|axon guidance|actin cytoskeleton|actin cytoskeleton organization|positive regulation of osteoblast differentiation|metal ion binding PDP1 1822.32515025952 1952.23333157713 1692.41696894192 0.86691326367975 -0.206040438601533 0.153827512441701 1 19.3397 17.9925 17.8843 15.092 GeneID:54704,Genbank:NM_018444.3,HGNC:HGNC:9279,MIM:605993 pyruvate dehyrogenase phosphatase catalytic subunit 1 GO:0004722,GO:0004741,GO:0005759,GO:0010510,GO:0035970,GO:0046872 protein serine/threonine phosphatase activity|[pyruvate dehydrogenase (lipoamide)] phosphatase activity|mitochondrial matrix|regulation of acetyl-CoA biosynthetic process from pyruvate|peptidyl-threonine dephosphorylation|metal ion binding PDP2 627.343306979258 676.526462064327 578.160151894189 0.854600942186374 -0.226677187315026 0.169796390788868 1 3.65478 3.9284 3.4215 3.24008 GeneID:57546,Genbank:NM_001329928.1,HGNC:HGNC:30263,MIM:615499 pyruvate dehyrogenase phosphatase catalytic subunit 2 GO:0004722,GO:0004741,GO:0005759,GO:0010510,GO:0046872 protein serine/threonine phosphatase activity|[pyruvate dehydrogenase (lipoamide)] phosphatase activity|mitochondrial matrix|regulation of acetyl-CoA biosynthetic process from pyruvate|metal ion binding PDPK1 1245.29160263534 1281.38784658415 1209.19535868654 0.943660705000397 -0.0836598658118627 0.576069468711161 1 4.37774 4.29774 4.40941 3.91564 GeneID:5170,Genbank:NM_002613.4,HGNC:HGNC:8816,MIM:605213 3-phosphoinositide dependent protein kinase 1 GO:0002223,GO:0003323,GO:0004674,GO:0004676,GO:0005158,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006351,GO:0006355,GO:0006468,GO:0006469,GO:0006972,GO:0007173,GO:0010518,GO:0010667,GO:0014069,GO:0016004,GO:0016301,GO:0016477,GO:0018105,GO:0018107,GO:0019722,GO:0019901,GO:0030036,GO:0030168,GO:0030512,GO:0031295,GO:0031410,GO:0032148,GO:0032869,GO:0034122,GO:0035556,GO:0038095,GO:0042995,GO:0043122,GO:0043204,GO:0043274,GO:0043304,GO:0043524,GO:0043536,GO:0045766,GO:0046777,GO:0048041,GO:0050852,GO:0051281,GO:0071364,GO:0097191,GO:1903078,GO:1905564,GO:1990416 stimulatory C-type lectin receptor signaling pathway|type B pancreatic cell development|protein serine/threonine kinase activity|3-phosphoinositide-dependent protein kinase activity|insulin receptor binding|ATP binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|focal adhesion|transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|negative regulation of protein kinase activity|hyperosmotic response|epidermal growth factor receptor signaling pathway|positive regulation of phospholipase activity|negative regulation of cardiac muscle cell apoptotic process|postsynaptic density|phospholipase activator activity|kinase activity|cell migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|calcium-mediated signaling|protein kinase binding|actin cytoskeleton organization|platelet activation|negative regulation of transforming growth factor beta receptor signaling pathway|T cell costimulation|cytoplasmic vesicle|activation of protein kinase B activity|cellular response to insulin stimulus|negative regulation of toll-like receptor signaling pathway|intracellular signal transduction|Fc-epsilon receptor signaling pathway|cell projection|regulation of I-kappaB kinase/NF-kappaB signaling|perikaryon|phospholipase binding|regulation of mast cell degranulation|negative regulation of neuron apoptotic process|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|protein autophosphorylation|focal adhesion assembly|T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|cellular response to epidermal growth factor stimulus|extrinsic apoptotic signaling pathway|positive regulation of protein localization to plasma membrane|positive regulation of vascular endothelial cell proliferation|cellular response to brain-derived neurotrophic factor stimulus hsa01524,hsa03320,hsa04068,hsa04071,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04510,hsa04660,hsa04664,hsa04722,hsa04910,hsa04919,hsa04931,hsa04960,hsa05145,hsa05160,hsa05205,hsa05213,hsa05215,hsa05223,hsa05231 Platinum drug resistance|PPAR signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Focal adhesion|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Neurotrophin signaling pathway|Insulin signaling pathway|Thyroid hormone signaling pathway|Insulin resistance|Aldosterone-regulated sodium reabsorption|Toxoplasmosis|Hepatitis C|Proteoglycans in cancer|Endometrial cancer|Prostate cancer|Non-small cell lung cancer|Choline metabolism in cancer PDPN 311.525972252998 288.195116966232 334.856827539764 1.16191013596875 0.216498492661852 0.276049514822727 1 3.56733 3.46972 3.98974 4.37896 GeneID:10630,Genbank:NM_006474.4,HGNC:HGNC:29602,MIM:608863 podoplanin GO:0000902,GO:0001726,GO:0001946,GO:0005102,GO:0005829,GO:0005886,GO:0005887,GO:0007266,GO:0008285,GO:0008360,GO:0010718,GO:0016020,GO:0016323,GO:0016324,GO:0019956,GO:0030027,GO:0030054,GO:0030168,GO:0030175,GO:0030324,GO:0030335,GO:0031258,GO:0031410,GO:0031527,GO:0031528,GO:0032587,GO:0042995,GO:0043066,GO:0044319,GO:0045121,GO:0048535,GO:0051087,GO:0051272,GO:0060838,GO:0061851,GO:0070252,GO:0071437,GO:0090091,GO:0097197,GO:1900024,GO:1901731,GO:1904328,GO:1905863,GO:2000392 cell morphogenesis|ruffle|lymphangiogenesis|receptor binding|cytosol|plasma membrane|integral component of plasma membrane|Rho protein signal transduction|negative regulation of cell proliferation|regulation of cell shape|positive regulation of epithelial to mesenchymal transition|membrane|basolateral plasma membrane|apical plasma membrane|chemokine binding|lamellipodium|cell junction|platelet activation|filopodium|lung development|positive regulation of cell migration|lamellipodium membrane|cytoplasmic vesicle|filopodium membrane|microvillus membrane|ruffle membrane|cell projection|negative regulation of apoptotic process|wound healing, spreading of cells|membrane raft|lymph node development|chaperone binding|positive regulation of cellular component movement|lymphatic endothelial cell fate commitment|leading edge of lamellipodium|actin-mediated cell contraction|invadopodium|positive regulation of extracellular matrix disassembly|tetraspanin-enriched microdomain|regulation of substrate adhesion-dependent cell spreading|positive regulation of platelet aggregation|regulation of myofibroblast contraction|invadopodium organization|regulation of lamellipodium morphogenesis PDPR 3049.9534740949 2974.32269060202 3125.58425758777 1.0508558023861 0.0715647173924771 0.599996194359103 1 9.63793 9.62497 11.3785 9.34866 GeneID:55066,Genbank:NM_017990.4,HGNC:HGNC:30264,MIM:617835 pyruvate dehydrogenase phosphatase regulatory subunit GO:0004741,GO:0005759,GO:0010510,GO:0016491 [pyruvate dehydrogenase (lipoamide)] phosphatase activity|mitochondrial matrix|regulation of acetyl-CoA biosynthetic process from pyruvate|oxidoreductase activity PDRG1 705.508356886913 754.908460412181 656.108253361645 0.869122930485385 -0.202367845743437 0.364641346574733 1 16.9585 19.6526 14.7104 17.9861 GeneID:81572,Genbank:NM_030815.2,HGNC:HGNC:16119,MIM:610789 p53 and DNA damage regulated 1 GO:0005737,GO:0006457,GO:0016272,GO:0051082 cytoplasm|protein folding|prefoldin complex|unfolded protein binding PDS5A 1151.20035571518 1158.41814231243 1143.98256911793 0.987538547034769 -0.0180910322489622 0.981684387117803 1 5.68613 4.77523 6.70766 3.84585 GeneID:23244,Genbank:NM_001100399.1,HGNC:HGNC:29088,MIM:613200 PDS5 cohesin associated factor A GO:0000775,GO:0000785,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0005886,GO:0006281,GO:0007062,GO:0007064,GO:0008156,GO:0051301 chromosome, centromeric region|chromatin|nucleus|nucleoplasm|chromosome|cytosol|plasma membrane|DNA repair|sister chromatid cohesion|mitotic sister chromatid cohesion|negative regulation of DNA replication|cell division PDS5B 220.835976038651 236.661184521555 205.010767555747 0.866262745917569 -0.207123420120296 0.368478594054096 1 0.994753 0.900354 0.885374 0.784889 GeneID:23047,Genbank:NM_015032.3,HGNC:HGNC:20418,MIM:605333 PDS5 cohesin associated factor B GO:0000775,GO:0000785,GO:0003677,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006281,GO:0007062,GO:0007064,GO:0008283,GO:0008285,GO:0042127,GO:0051301 chromosome, centromeric region|chromatin|DNA binding|ATP binding|nucleus|nucleoplasm|chromosome|cytosol|DNA repair|sister chromatid cohesion|mitotic sister chromatid cohesion|cell proliferation|negative regulation of cell proliferation|regulation of cell proliferation|cell division PDSS1 232.063390442218 263.019179022775 201.107601861661 0.764611929095282 -0.387200386328254 0.0758970576409953 0.94157495521624 1.24295 1.17356 0.77538 0.968755 GeneID:23590,Genbank:NM_001321979.1,HGNC:HGNC:17759,MIM:607429 decaprenyl diphosphate synthase subunit 1 GO:0000010,GO:0005759,GO:0006744,GO:0008299,GO:0046872,GO:0046982,GO:0050347,GO:0051290,GO:1990234 trans-hexaprenyltranstransferase activity|mitochondrial matrix|ubiquinone biosynthetic process|isoprenoid biosynthetic process|metal ion binding|protein heterodimerization activity|trans-octaprenyltranstransferase activity|protein heterotetramerization|transferase complex hsa00900 Terpenoid backbone biosynthesis PDSS2 415.454866302512 387.485472463127 443.424260141897 1.14436357400236 0.194545481380403 0.286136959847703 1 3.3469 3.58162 3.97858 3.90457 GeneID:57107,Genbank:XM_011535962.2,HGNC:HGNC:23041,MIM:610564 decaprenyl diphosphate synthase subunit 2 GO:0000010,GO:0005759,GO:0005829,GO:0006744,GO:0008299,GO:0046982,GO:0050347,GO:0050878,GO:0051290,GO:1990234 trans-hexaprenyltranstransferase activity|mitochondrial matrix|cytosol|ubiquinone biosynthetic process|isoprenoid biosynthetic process|protein heterodimerization activity|trans-octaprenyltranstransferase activity|regulation of body fluid levels|protein heterotetramerization|transferase complex hsa00900 Terpenoid backbone biosynthesis PDXDC1 2439.90280053614 2329.62246070045 2550.18314037182 1.09467657673812 0.130504687124979 0.350077887437304 1 9.9379 10.0918 11.8357 10.5574 GeneID:23042,Genbank:XM_024450195.1,HGNC:HGNC:28995,MIM:614244 pyridoxal dependent decarboxylase domain containing 1 GO:0005794,GO:0016831,GO:0019752,GO:0030170,GO:0043231,GO:0045296 Golgi apparatus|carboxy-lyase activity|carboxylic acid metabolic process|pyridoxal phosphate binding|intracellular membrane-bounded organelle|cadherin binding PDXK 2077.45091101385 2036.54828102657 2118.35354100113 1.04016858364552 0.0568173697884636 0.715698013724237 1 7.78221 9.156 9.45921 8.65394 GeneID:8566,Genbank:NM_003681.4,HGNC:HGNC:8819,MIM:179020 pyridoxal kinase GO:0000287,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0008270,GO:0008283,GO:0008478,GO:0009443,GO:0030170,GO:0030955,GO:0031402,GO:0031403,GO:0034774,GO:0035580,GO:0042803,GO:0042816,GO:0042823,GO:0043312,GO:0070062 magnesium ion binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytosol|zinc ion binding|cell proliferation|pyridoxal kinase activity|pyridoxal 5'-phosphate salvage|pyridoxal phosphate binding|potassium ion binding|sodium ion binding|lithium ion binding|secretory granule lumen|specific granule lumen|protein homodimerization activity|vitamin B6 metabolic process|pyridoxal phosphate biosynthetic process|neutrophil degranulation|extracellular exosome hsa00750 Vitamin B6 metabolism PDXP 1073.84355254792 964.279533903287 1183.40757119256 1.22724534700251 0.295423696857453 0.0512359885860359 0.828048025422755 27.8338 26.7726 33.2609 35.3679 GeneID:57026,Genbank:NM_020315.4,HGNC:HGNC:30259,MIM:609246 pyridoxal phosphatase GO:0000287,GO:0004647,GO:0004721,GO:0005829,GO:0005856,GO:0006470,GO:0007088,GO:0030836,GO:0031072,GO:0031247,GO:0031258,GO:0032361,GO:0032465,GO:0032587,GO:0033883,GO:0070062,GO:0071318,GO:0098519 magnesium ion binding|phosphoserine phosphatase activity|phosphoprotein phosphatase activity|cytosol|cytoskeleton|protein dephosphorylation|regulation of mitotic nuclear division|positive regulation of actin filament depolymerization|heat shock protein binding|actin rod assembly|lamellipodium membrane|pyridoxal phosphate catabolic process|regulation of cytokinesis|ruffle membrane|pyridoxal phosphatase activity|extracellular exosome|cellular response to ATP|nucleotide phosphatase activity, acting on free nucleotides hsa00750 Vitamin B6 metabolism PDZD11 2479.4516045148 2352.80970407161 2606.09350495798 1.10765163049441 0.147504208115238 0.406695885871282 1 47.8361 51.4141 50.5223 59.5178 GeneID:51248,Genbank:NM_016484.4,HGNC:HGNC:28034,MIM:300632 PDZ domain containing 11 GO:0005576,GO:0005829,GO:0005911,GO:0006768,GO:0007269,GO:0008022,GO:0015939,GO:0016323,GO:0019730,GO:0034220,GO:0045199,GO:0045202,GO:0055085,GO:0098793,GO:1903361 extracellular region|cytosol|cell-cell junction|biotin metabolic process|neurotransmitter secretion|protein C-terminus binding|pantothenate metabolic process|basolateral plasma membrane|antimicrobial humoral response|ion transmembrane transport|maintenance of epithelial cell apical/basal polarity|synapse|transmembrane transport|presynapse|protein localization to basolateral plasma membrane PDZD2 154.678029716273 146.932125690382 162.423933742163 1.10543513189502 0.144614368764138 0.852727309752998 1 0.394815 0.358871 0.627113 0.212577 GeneID:23037,Genbank:XM_005248269.4,HGNC:HGNC:18486,MIM:610697 PDZ domain containing 2 GO:0005576,GO:0005634,GO:0005737,GO:0005783,GO:0005911,GO:0007155 extracellular region|nucleus|cytoplasm|endoplasmic reticulum|cell-cell junction|cell adhesion PDZD4 133.974457554254 138.56269423753 129.386220870978 0.933773852933163 -0.0988549033642257 0.722185402185902 1 1.38349 1.21131 1.17079 1.34174 GeneID:57595,Genbank:NM_001303514.1,HGNC:HGNC:21167,MIM:300634 PDZ domain containing 4 GO:0005938 cell cortex PDZD7 81.3414143685098 68.6570055478609 94.0258231891586 1.36950078784915 0.453650096000012 0.176924942594041 1 0.267926 0.344768 0.476677 0.400899 GeneID:79955,Genbank:NM_001195263.1,HGNC:HGNC:26257,MIM:612971 PDZ domain containing 7 GO:0002141,GO:0005615,GO:0005634,GO:0005929,GO:0042803,GO:0045184,GO:0046982,GO:0050910,GO:0060088,GO:1990696 stereocilia ankle link|extracellular space|nucleus|cilium|protein homodimerization activity|establishment of protein localization|protein heterodimerization activity|detection of mechanical stimulus involved in sensory perception of sound|auditory receptor cell stereocilium organization|USH2 complex PDZD8 721.215136926475 742.030299790634 700.399974062316 0.943896730712931 -0.0832990681796134 0.76110482828638 1 4.74988 4.41153 5.33533 3.48517 GeneID:118987,Genbank:NM_173791.4,HGNC:HGNC:26974,MIM:614235 PDZ domain containing 8 GO:0005739,GO:0005789,GO:0006869,GO:0007010,GO:0008289,GO:0016020,GO:0016021,GO:0016032,GO:0022604,GO:0035556,GO:0044233,GO:0046872,GO:0051560,GO:1990456 mitochondrion|endoplasmic reticulum membrane|lipid transport|cytoskeleton organization|lipid binding|membrane|integral component of membrane|viral process|regulation of cell morphogenesis|intracellular signal transduction|ER-mitochondrion membrane contact site|metal ion binding|mitochondrial calcium ion homeostasis|mitochondrion-endoplasmic reticulum membrane tethering PDZD9 60.6735047775576 68.0512642863177 53.2957452687975 0.783170538089665 -0.352601601334173 0.415707598843282 1 0.351637 0.411297 0.0849134 0.394453 GeneID:255762,Genbank:XM_017023109.1,HGNC:HGNC:28740 PDZ domain containing 9 PDZK1 6.37122122935844 9.34957425676688 3.39286820195 0.362890128338664 -1.46239528301518 0.239065177103951 1 0.091934 0.0259988 0.00881956 0.0245953 GeneID:5174,Genbank:NM_001201326.1,HGNC:HGNC:8821,MIM:603831 PDZ domain containing 1 GO:0005124,GO:0005215,GO:0005886,GO:0008283,GO:0015879,GO:0015893,GO:0016324,GO:0030165,GO:0031526,GO:0031528,GO:0032403,GO:0032414,GO:0044070,GO:0045121,GO:0070062,GO:0090314,GO:1904064 scavenger receptor binding|transporter activity|plasma membrane|cell proliferation|carnitine transport|drug transport|apical plasma membrane|PDZ domain binding|brush border membrane|microvillus membrane|protein complex binding|positive regulation of ion transmembrane transporter activity|regulation of anion transport|membrane raft|extracellular exosome|positive regulation of protein targeting to membrane|positive regulation of cation transmembrane transport PDZK1IP1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0547291 0 0 GeneID:10158,Genbank:NM_005764.3,HGNC:HGNC:16887,MIM:607178 PDZK1 interacting protein 1 PDZRN3 316.69895409227 250.018590889098 383.379317295442 1.53340323986347 0.616737133169409 0.00191095362047496 0.155161689175677 1.6101 1.7945 3.08127 2.17283 GeneID:23024,Genbank:XM_017005942.2,HGNC:HGNC:17704,MIM:609729 PDZ domain containing ring finger 3 GO:0004842,GO:0005634,GO:0005654,GO:0005829,GO:0007528,GO:0008270,GO:0016567,GO:0030054,GO:0031594,GO:0061630 ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytosol|neuromuscular junction development|zinc ion binding|protein ubiquitination|cell junction|neuromuscular junction|ubiquitin protein ligase activity PEA15 16303.2822596592 16383.6037602055 16222.9607591128 0.990194892195642 -0.0142155875414623 0.894650566238899 1 161.472 175.146 161.308 176.999 GeneID:8682,Genbank:NM_001297576.1,HGNC:HGNC:8822,MIM:603434 proliferation and apoptosis adaptor protein 15 PEAK1 776.949163402408 740.560085584762 813.338241220054 1.09827447772563 0.135238653766983 0.613640017161318 1 1.8114 1.6681 2.31227 1.51477 GeneID:79834,Genbank:XM_011522040.1,HGNC:HGNC:29431,MIM:614248 pseudopodium enriched atypical kinase 1 GO:0004715,GO:0005524,GO:0005737,GO:0005925,GO:0015629,GO:0016477,GO:0034446,GO:0046777 non-membrane spanning protein tyrosine kinase activity|ATP binding|cytoplasm|focal adhesion|actin cytoskeleton|cell migration|substrate adhesion-dependent cell spreading|protein autophosphorylation PEAK3 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.0239068 0.0259806 0.0243985 GeneID:374872,Genbank:NM_198532.2,HGNC:HGNC:24793 PEAK family member 3 GO:0004672,GO:0005925,GO:0015629 protein kinase activity|focal adhesion|actin cytoskeleton PEAR1 67.4507446624757 89.3546572888011 45.5468320361503 0.509730924141307 -0.97219221417308 0.00623708684847196 0.315120450994091 0.5576 0.52254 0.213404 0.33924 GeneID:375033,Genbank:XM_005245141.3,HGNC:HGNC:33631,MIM:610278 platelet endothelial aggregation receptor 1 GO:0001891,GO:0016021,GO:0043654,GO:0045746 phagocytic cup|integral component of membrane|recognition of apoptotic cell|negative regulation of Notch signaling pathway PEBP1 6500.81982512479 6474.76729349473 6526.87235675486 1.00804740323447 0.0115634828887185 0.96407943823467 1 179.223 196.28 176.877 204.916 GeneID:5037,Genbank:NM_002567.3,HGNC:HGNC:8630,MIM:604591 phosphatidylethanolamine binding protein 1 PEBP4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:157310,Genbank:XM_011544414.2,HGNC:HGNC:28319,MIM:612473 phosphatidylethanolamine binding protein 4 GO:0005764,GO:0070062 lysosome|extracellular exosome PECAM1 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0 0 0.00484697 0 GeneID:5175,Genbank:NM_000442.4,HGNC:HGNC:8823,MIM:173445 platelet and endothelial cell adhesion molecule 1 hsa04514,hsa04670,hsa05144,hsa05418 Cell adhesion molecules (CAMs)|Leukocyte transendothelial migration|Malaria|Fluid shear stress and atherosclerosis PECR 279.693581747922 256.994243375232 302.392920120613 1.17665250454305 0.23468831868312 0.246119040119957 1 1.57687 1.37407 1.75771 1.76023 GeneID:55825,Genbank:XM_024452998.1,HGNC:HGNC:18281,MIM:605843 peroxisomal trans-2-enoyl-CoA reductase GO:0001561,GO:0005102,GO:0005739,GO:0005777,GO:0005778,GO:0006633,GO:0019166,GO:0033306,GO:0055114 fatty acid alpha-oxidation|receptor binding|mitochondrion|peroxisome|peroxisomal membrane|fatty acid biosynthetic process|trans-2-enoyl-CoA reductase (NADPH) activity|phytol metabolic process|oxidation-reduction process hsa04146 Peroxisome PEF1 1824.77593071013 1766.38771938168 1883.16414203857 1.06611030034661 0.0923567078259378 0.528176277081156 1 14.4353 15.3464 15.4136 16.6522 GeneID:553115,Genbank:NM_012392.3,HGNC:HGNC:30009,MIM:610033 penta-EF-hand domain containing 1 GO:0000139,GO:0003723,GO:0004198,GO:0005509,GO:0005737,GO:0005783,GO:0006508,GO:0006888,GO:0014029,GO:0014032,GO:0030127,GO:0046982,GO:0046983,GO:0048208,GO:0048306,GO:0051592,GO:0060090,GO:0070062,GO:1902527 Golgi membrane|RNA binding|calcium-dependent cysteine-type endopeptidase activity|calcium ion binding|cytoplasm|endoplasmic reticulum|proteolysis|ER to Golgi vesicle-mediated transport|neural crest formation|neural crest cell development|COPII vesicle coat|protein heterodimerization activity|protein dimerization activity|COPII vesicle coating|calcium-dependent protein binding|response to calcium ion|molecular adaptor activity|extracellular exosome|positive regulation of protein monoubiquitination PEG10 9411.16158199787 7982.40777694545 10839.9153870503 1.3579756496978 0.441457610381477 0.21668109904383 1 44.2785 41.8762 74.0759 44.8986 GeneID:23089,Genbank:NM_001172437.2,HGNC:HGNC:14005,MIM:609810 paternally expressed 10 PEG3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00382737 0 0 GeneID:5178,Genbank:NM_001146185.1,HGNC:HGNC:8826,MIM:601483 paternally expressed 3 PELI1 71.9316987592844 74.0761999338609 69.7871975847079 0.942100129961007 -0.0860476918208548 0.830550768226836 1 0.392345 0.320695 0.37301 0.315872 GeneID:57162,Genbank:NM_020651.3,HGNC:HGNC:8827,MIM:614797 pellino E3 ubiquitin protein ligase 1 GO:0001819,GO:0004674,GO:0005634,GO:0005829,GO:0006955,GO:0008063,GO:0030890,GO:0031398,GO:0032088,GO:0032496,GO:0034141,GO:0034145,GO:0034450,GO:0042130,GO:0043123,GO:0043331,GO:0061630,GO:0070498,GO:0070936 positive regulation of cytokine production|protein serine/threonine kinase activity|nucleus|cytosol|immune response|Toll signaling pathway|positive regulation of B cell proliferation|positive regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|response to lipopolysaccharide|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|ubiquitin-ubiquitin ligase activity|negative regulation of T cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to dsRNA|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway|protein K48-linked ubiquitination PELI2 245.020380509104 243.358488014687 246.68227300352 1.01365797846604 0.019570950164811 0.902820920974299 1 0.538043 0.428807 0.506431 0.44403 GeneID:57161,Genbank:XM_005267890.5,HGNC:HGNC:8828,MIM:614798 pellino E3 ubiquitin protein ligase family member 2 GO:0000209,GO:0001934,GO:0004674,GO:0005829,GO:0006955,GO:0008063,GO:0034450,GO:0043123,GO:0043410,GO:0061630,GO:0070498 protein polyubiquitination|positive regulation of protein phosphorylation|protein serine/threonine kinase activity|cytosol|immune response|Toll signaling pathway|ubiquitin-ubiquitin ligase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway PELI3 194.289783793373 195.698117511839 192.881450074907 0.985607079553224 -0.0209154760302319 0.946619217412692 1 2.66883 2.38473 2.78105 2.55182 GeneID:246330,Genbank:NM_001243135.1,HGNC:HGNC:30010,MIM:609827 pellino E3 ubiquitin protein ligase family member 3 GO:0004674,GO:0005829,GO:0006955,GO:0008063,GO:0010804,GO:0061630,GO:0070498,GO:0070534,GO:2001237 protein serine/threonine kinase activity|cytosol|immune response|Toll signaling pathway|negative regulation of tumor necrosis factor-mediated signaling pathway|ubiquitin protein ligase activity|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination|negative regulation of extrinsic apoptotic signaling pathway PELO 1192.42347473976 1184.8948576758 1199.95209180373 1.01270765421116 0.0182177608211367 0.922986152216033 1 19.362 21.0908 21.6852 20.1302 GeneID:53918,Genbank:NM_015946.4,HGNC:HGNC:8829,MIM:605757 pelota mRNA surveillance and ribosome rescue factor GO:0004519,GO:0005634,GO:0005737,GO:0006412,GO:0007049,GO:0007492,GO:0008283,GO:0019827,GO:0030513,GO:0032790,GO:0043022,GO:0046872,GO:0051276,GO:0051301,GO:0060231,GO:0070481,GO:0070651,GO:0070966,GO:0071025 endonuclease activity|nucleus|cytoplasm|translation|cell cycle|endoderm development|cell proliferation|stem cell population maintenance|positive regulation of BMP signaling pathway|ribosome disassembly|ribosome binding|metal ion binding|chromosome organization|cell division|mesenchymal to epithelial transition|nuclear-transcribed mRNA catabolic process, non-stop decay|nonfunctional rRNA decay|nuclear-transcribed mRNA catabolic process, no-go decay|RNA surveillance hsa03015 mRNA surveillance pathway PELP1 1717.4859313223 1832.31601892676 1602.65584371785 0.874661263211886 -0.193203693373576 0.167547356736017 1 15.611 16.7661 14.5864 14.3462 GeneID:27043,Genbank:NM_014389.2,HGNC:HGNC:30134,MIM:609455 proline, glutamate and leucine rich protein 1 GO:0003682,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006351,GO:0006364,GO:0008134,GO:0016020,GO:0035327,GO:0045944,GO:0071339,GO:0071391 chromatin binding|RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|transcription, DNA-templated|rRNA processing|transcription factor binding|membrane|transcriptionally active chromatin|positive regulation of transcription from RNA polymerase II promoter|MLL1 complex|cellular response to estrogen stimulus PEMT 377.754688367706 368.306061202744 387.203315532669 1.05130856187436 0.0721861663045011 0.713437911440974 1 3.67848 4.01556 3.73448 3.93158 GeneID:10400,Genbank:XM_006721418.4,HGNC:HGNC:8830,MIM:602391 phosphatidylethanolamine N-methyltransferase hsa00564 Glycerophospholipid metabolism PEPD 2536.06225813352 2419.83381628018 2652.29069998687 1.09606316026446 0.132330935501777 0.349727296659751 1 55.4767 56.4977 61.8652 62.2168 GeneID:5184,Genbank:NM_001166057.1,HGNC:HGNC:8840,MIM:613230 peptidase D GO:0004177,GO:0004181,GO:0005634,GO:0005654,GO:0006508,GO:0006520,GO:0030145,GO:0030574,GO:0070062,GO:0102009 aminopeptidase activity|metallocarboxypeptidase activity|nucleus|nucleoplasm|proteolysis|cellular amino acid metabolic process|manganese ion binding|collagen catabolic process|extracellular exosome|proline dipeptidase activity PER1 539.462918050816 574.429948324635 504.495887776997 0.878254849435331 -0.187288457328714 0.274973124836495 1 3.98262 3.82106 3.45322 3.46116 GeneID:5187,Genbank:XM_005256689.2,HGNC:HGNC:8845,MIM:602260 period circadian regulator 1 GO:0000122,GO:0000978,GO:0000989,GO:0002028,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0007623,GO:0008134,GO:0009649,GO:0010608,GO:0019900,GO:0031490,GO:0031625,GO:0032922,GO:0042634,GO:0042752,GO:0043124,GO:0043153,GO:0043966,GO:0043967,GO:0045892,GO:0045944,GO:0046329,GO:0051591,GO:0070888,GO:0070932,GO:0097167,GO:1900015,GO:1900744,GO:2000323 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, transcription factor binding|regulation of sodium ion transport|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|circadian rhythm|transcription factor binding|entrainment of circadian clock|posttranscriptional regulation of gene expression|kinase binding|chromatin DNA binding|ubiquitin protein ligase binding|circadian regulation of gene expression|regulation of hair cycle|regulation of circadian rhythm|negative regulation of I-kappaB kinase/NF-kappaB signaling|entrainment of circadian clock by photoperiod|histone H3 acetylation|histone H4 acetylation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of JNK cascade|response to cAMP|E-box binding|histone H3 deacetylation|circadian regulation of translation|regulation of cytokine production involved in inflammatory response|regulation of p38MAPK cascade|negative regulation of glucocorticoid receptor signaling pathway hsa04710,hsa04713,hsa05168 Circadian rhythm|Circadian entrainment|Herpes simplex infection PER2 102.228218454747 98.8002840949379 105.656152814557 1.06939118427059 0.0967896887675139 0.745327706495319 1 0.607132 0.469116 0.643326 0.49721 GeneID:8864,Genbank:XM_005246111.4,HGNC:HGNC:8846,MIM:603426 period circadian regulator 2 GO:0000122,GO:0000976,GO:0000989,GO:0002931,GO:0003713,GO:0005634,GO:0005730,GO:0005978,GO:0006094,GO:0006351,GO:0006631,GO:0007623,GO:0019229,GO:0019249,GO:0031397,GO:0032922,GO:0042752,GO:0042754,GO:0045892,GO:0048471,GO:0050767,GO:0050796,GO:0050872,GO:0051726,GO:0051946,GO:0070345,GO:0070932,GO:0097167,GO:2000678 negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|transcription factor activity, transcription factor binding|response to ischemia|transcription coactivator activity|nucleus|nucleolus|glycogen biosynthetic process|gluconeogenesis|transcription, DNA-templated|fatty acid metabolic process|circadian rhythm|regulation of vasoconstriction|lactate biosynthetic process|negative regulation of protein ubiquitination|circadian regulation of gene expression|regulation of circadian rhythm|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm|regulation of neurogenesis|regulation of insulin secretion|white fat cell differentiation|regulation of cell cycle|regulation of glutamate uptake involved in transmission of nerve impulse|negative regulation of fat cell proliferation|histone H3 deacetylation|circadian regulation of translation|negative regulation of transcription regulatory region DNA binding hsa04710,hsa04713,hsa05168,hsa05202,hsa05221 Circadian rhythm|Circadian entrainment|Herpes simplex infection|Transcriptional misregulation in cancer|Acute myeloid leukemia PER3 291.728820469103 296.054859706911 287.402781231294 0.970775421541189 -0.042790512633916 0.861414250029617 1 1.25066 1.05685 1.25476 0.984841 GeneID:8863,Genbank:XM_017002734.1,HGNC:HGNC:8847,MIM:603427 period circadian regulator 3 GO:0000122,GO:0005634,GO:0005737,GO:0006351,GO:0019900,GO:0031625,GO:0032922,GO:0045187,GO:0050821 negative regulation of transcription from RNA polymerase II promoter|nucleus|cytoplasm|transcription, DNA-templated|kinase binding|ubiquitin protein ligase binding|circadian regulation of gene expression|regulation of circadian sleep/wake cycle, sleep|protein stabilization hsa04710,hsa04713,hsa05168 Circadian rhythm|Circadian entrainment|Herpes simplex infection PERM1 3.18272180910757 1.51824048055703 4.84720313765811 3.19264517033541 1.67475222110618 0.398225446118864 1 0.0122037 0.0207993 0.0336917 0.021054 GeneID:84808,Genbank:XM_017002585.1,HGNC:HGNC:28208,MIM:615921 PPARGC1 and ESRR induced regulator, muscle 1 GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0014850 nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|response to muscle activity PERP 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0103243 0 0.00963575 GeneID:64065,Genbank:NM_022121.4,HGNC:HGNC:17637,MIM:609301 PERP, TP53 apoptosis effector GO:0002934,GO:0005739,GO:0005794,GO:0005886,GO:0005887,GO:0007219,GO:0030057,GO:0034113,GO:0042981,GO:0045862,GO:0070268,GO:0072332,GO:0097186,GO:0097202 desmosome organization|mitochondrion|Golgi apparatus|plasma membrane|integral component of plasma membrane|Notch signaling pathway|desmosome|heterotypic cell-cell adhesion|regulation of apoptotic process|positive regulation of proteolysis|cornification|intrinsic apoptotic signaling pathway by p53 class mediator|amelogenesis|activation of cysteine-type endopeptidase activity hsa04115 p53 signaling pathway PES1 2427.58217890123 2478.621750204 2376.54260759846 0.958816167655621 -0.0606738588248763 0.647823004119057 1 13.8966 14.8868 13.8679 14.3072 GeneID:23481,Genbank:NM_001282327.1,HGNC:HGNC:8848,MIM:605819 pescadillo ribosomal biogenesis factor 1 GO:0000463,GO:0000466,GO:0000793,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0007000,GO:0008283,GO:0016020,GO:0030687,GO:0033365,GO:0042273,GO:0051726,GO:0070545 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|condensed chromosome|RNA binding|nucleus|nucleoplasm|nucleolus|cytosol|rRNA processing|nucleolus organization|cell proliferation|membrane|preribosome, large subunit precursor|protein localization to organelle|ribosomal large subunit biogenesis|regulation of cell cycle|PeBoW complex PET100 838.107717455381 855.409281431308 820.806153479453 0.95954786941994 -0.0595733142592137 0.846947415978371 1 150.864 160.862 118.478 176.625 GeneID:100131801,Genbank:NM_001171155.1,HGNC:HGNC:40038,MIM:614770 PET100 homolog GO:0031305,GO:0033617,GO:0051082 integral component of mitochondrial inner membrane|mitochondrial respiratory chain complex IV assembly|unfolded protein binding PET117 5.34892522218236 8.27337890348227 2.42447154088245 0.293044905735188 -1.77080633700635 0.199413363812635 1 4.28016 6.01174 6.40959 5.21419 GeneID:100303755,Genbank:NM_001164811.1,HGNC:HGNC:40045,MIM:614771 PET117 homolog GO:0000086,GO:0004402,GO:0005634,GO:0005671,GO:0005737,GO:0030274,GO:0043966 G2/M transition of mitotic cell cycle|histone acetyltransferase activity|nucleus|Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|LIM domain binding|histone H3 acetylation PEX1 380.528552506952 412.603575476792 348.453529537112 0.844523775962073 -0.243790054951614 0.193808717063715 1 2.7566 2.87277 2.49288 2.2774 GeneID:5189,Genbank:NM_001282677.1,HGNC:HGNC:8850,MIM:602136 peroxisomal biogenesis factor 1 hsa04146 Peroxisome PEX10 1441.18262306769 1379.60302372861 1502.76222240676 1.08927147633041 0.123363558045307 0.404129160530005 1 28.4129 28.8303 30.57 32.764 GeneID:5192,Genbank:NM_002617.3,HGNC:HGNC:8851,MIM:602859 peroxisomal biogenesis factor 10 hsa04146 Peroxisome PEX11A 101.852819384529 101.46236351368 102.243275255378 1.00769656564912 0.011061284536677 1 1 1.15164 1.63704 1.22537 1.63155 GeneID:8800,Genbank:NM_001271573.1,HGNC:HGNC:8852,MIM:603866 peroxisomal biogenesis factor 11 alpha GO:0005777,GO:0005778,GO:0005779,GO:0007031,GO:0007165,GO:0016557,GO:0016559,GO:0019216,GO:0042803,GO:0043234,GO:0044375,GO:0050873 peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|peroxisome organization|signal transduction|peroxisome membrane biogenesis|peroxisome fission|regulation of lipid metabolic process|protein homodimerization activity|protein complex|regulation of peroxisome size|brown fat cell differentiation hsa04146 Peroxisome PEX11B 501.437762921864 482.374993997514 520.500531846213 1.07903713567892 0.109744516853632 0.530008376654219 1 11.9585 11.5848 13.1051 12.0524 GeneID:8799,Genbank:NM_003846.2,HGNC:HGNC:8853,MIM:603867 peroxisomal biogenesis factor 11 beta GO:0005777,GO:0005778,GO:0005779,GO:0007031,GO:0007165,GO:0016020,GO:0016559,GO:0042803,GO:0043234,GO:0044375,GO:0051260,GO:0070062 peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|peroxisome organization|signal transduction|membrane|peroxisome fission|protein homodimerization activity|protein complex|regulation of peroxisome size|protein homooligomerization|extracellular exosome hsa04146 Peroxisome PEX11G 37.3964186976371 30.2109221319778 44.5819152632964 1.47568866215133 0.561388376581906 0.234146423762077 1 0.51166 0.470322 0.653177 0.656325 GeneID:92960,Genbank:NM_001270539.1,HGNC:HGNC:20208,MIM:607583 peroxisomal biogenesis factor 11 gamma GO:0005777,GO:0005779,GO:0016559,GO:0031231,GO:0043234,GO:0044375 peroxisome|integral component of peroxisomal membrane|peroxisome fission|intrinsic component of peroxisomal membrane|protein complex|regulation of peroxisome size hsa04146 Peroxisome PEX12 190.573458566617 173.712548008659 207.434369124576 1.19412426737438 0.255952979480431 0.267143999961257 1 2.94895 2.69881 3.79935 3.06614 GeneID:5193,Genbank:NM_000286.2,HGNC:HGNC:8854,MIM:601758 peroxisomal biogenesis factor 12 hsa04146 Peroxisome PEX13 420.121234974286 420.069299364883 420.173170583688 1.00024727162628 0.000356693450722662 0.9828338201432 1 4.17592 3.76499 4.13416 3.91744 GeneID:5194,Genbank:NM_002618.3,HGNC:HGNC:8855,MIM:601789 peroxisomal biogenesis factor 13 GO:0001561,GO:0001764,GO:0001967,GO:0005777,GO:0005778,GO:0005779,GO:0007626,GO:0016020,GO:0016560,GO:0021795,GO:0043231,GO:0060152 fatty acid alpha-oxidation|neuron migration|suckling behavior|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|locomotory behavior|membrane|protein import into peroxisome matrix, docking|cerebral cortex cell migration|intracellular membrane-bounded organelle|microtubule-based peroxisome localization hsa04146 Peroxisome PEX14 746.979232205835 728.761171319063 765.197293092608 1.04999734234961 0.0703856762876996 0.664932289646093 1 4.63552 4.49735 4.64173 4.83968 GeneID:5195,Genbank:NM_004565.2,HGNC:HGNC:8856,MIM:601791 peroxisomal biogenesis factor 14 GO:0001650,GO:0003714,GO:0005102,GO:0005622,GO:0005634,GO:0005777,GO:0005778,GO:0006461,GO:0007031,GO:0008017,GO:0016020,GO:0016021,GO:0016558,GO:0016561,GO:0032091,GO:0034453,GO:0036250,GO:0043234,GO:0043433,GO:0044721,GO:0045892,GO:0047485,GO:0048487,GO:0051260,GO:1901094,GO:1990429 fibrillar center|transcription corepressor activity|receptor binding|intracellular|nucleus|peroxisome|peroxisomal membrane|protein complex assembly|peroxisome organization|microtubule binding|membrane|integral component of membrane|protein import into peroxisome matrix|protein import into peroxisome matrix, translocation|negative regulation of protein binding|microtubule anchoring|peroxisome transport along microtubule|protein complex|negative regulation of DNA binding transcription factor activity|protein import into peroxisome matrix, substrate release|negative regulation of transcription, DNA-templated|protein N-terminus binding|beta-tubulin binding|protein homooligomerization|negative regulation of protein homotetramerization|peroxisomal importomer complex hsa04146 Peroxisome PEX16 377.696271366827 354.151825475774 401.240717257881 1.13296244264405 0.180100037054935 0.341265660845802 1 7.11756 7.48041 8.43012 9.7906 GeneID:9409,Genbank:NM_057174.2,HGNC:HGNC:8857,MIM:603360 peroxisomal biogenesis factor 16 GO:0005777,GO:0005778,GO:0005779,GO:0005783,GO:0005789,GO:0006625,GO:0007031,GO:0008022,GO:0016020,GO:0016557,GO:0016558,GO:0022615,GO:0032581,GO:0045046,GO:0070972 peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|protein targeting to peroxisome|peroxisome organization|protein C-terminus binding|membrane|peroxisome membrane biogenesis|protein import into peroxisome matrix|protein to membrane docking|ER-dependent peroxisome organization|protein import into peroxisome membrane|protein localization to endoplasmic reticulum hsa04146 Peroxisome PEX19 2083.51900787462 2083.7155291249 2083.32248662434 0.999811374203884 -0.000272155169190349 0.996629885334134 1 22.5007 22.113 21.962 23.0338 GeneID:5824,Genbank:NM_001193644.1,HGNC:HGNC:9713,MIM:600279 peroxisomal biogenesis factor 19 GO:0005634,GO:0005654,GO:0005737,GO:0005777,GO:0005778,GO:0005829,GO:0006625,GO:0007031,GO:0016021,GO:0016557,GO:0016559,GO:0031526,GO:0036105,GO:0043234,GO:0045046,GO:0047485,GO:0050821,GO:0051117,GO:0055085,GO:0061077,GO:0072321,GO:0072663,GO:1900131 nucleus|nucleoplasm|cytoplasm|peroxisome|peroxisomal membrane|cytosol|protein targeting to peroxisome|peroxisome organization|integral component of membrane|peroxisome membrane biogenesis|peroxisome fission|brush border membrane|peroxisome membrane class-1 targeting sequence binding|protein complex|protein import into peroxisome membrane|protein N-terminus binding|protein stabilization|ATPase binding|transmembrane transport|chaperone-mediated protein folding|chaperone-mediated protein transport|establishment of protein localization to peroxisome|negative regulation of lipid binding hsa04146 Peroxisome PEX2 763.060182096774 763.824781195929 762.295582997619 0.997997972524647 -0.00289121021822215 0.985736472619998 1 7.94447 8.43727 8.13 8.29143 GeneID:5828,Genbank:NM_001172087.1,HGNC:HGNC:9717,MIM:170993 peroxisomal biogenesis factor 2 GO:0000038,GO:0000122,GO:0005778,GO:0005779,GO:0006635,GO:0007031,GO:0016020,GO:0016558,GO:0016567,GO:0016593,GO:0031648,GO:0046872,GO:0048147,GO:0050680,GO:0061630 very long-chain fatty acid metabolic process|negative regulation of transcription from RNA polymerase II promoter|peroxisomal membrane|integral component of peroxisomal membrane|fatty acid beta-oxidation|peroxisome organization|membrane|protein import into peroxisome matrix|protein ubiquitination|Cdc73/Paf1 complex|protein destabilization|metal ion binding|negative regulation of fibroblast proliferation|negative regulation of epithelial cell proliferation|ubiquitin protein ligase activity hsa04146 Peroxisome PEX26 1404.62922114935 1367.96678859633 1441.29165370236 1.0536013488904 0.0753290977422238 0.620907691434912 1 14.6831 15.7822 17.0218 15.8235 GeneID:55670,Genbank:NM_017929.5,HGNC:HGNC:22965,MIM:608666 peroxisomal biogenesis factor 26 hsa04146 Peroxisome PEX3 274.912641577355 282.294642832528 267.530640322181 0.947700025894202 -0.0774976176623674 0.735705964526877 1 4.7152 4.35303 4.57211 3.8583 GeneID:8504,Genbank:NM_003630.2,HGNC:HGNC:8858,MIM:603164 peroxisomal biogenesis factor 3 GO:0005654,GO:0005777,GO:0005778,GO:0005779,GO:0005783,GO:0005829,GO:0007031,GO:0008289,GO:0016020,GO:0016557,GO:0032994,GO:0043234,GO:0045046,GO:0046983,GO:0055085 nucleoplasm|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum|cytosol|peroxisome organization|lipid binding|membrane|peroxisome membrane biogenesis|protein-lipid complex|protein complex|protein import into peroxisome membrane|protein dimerization activity|transmembrane transport hsa04146 Peroxisome PEX5 457.542210716741 458.554617401198 456.529804032284 0.995584357256309 -0.00638453219199851 0.962844178893155 1 3.59666 3.76201 4.24183 3.66138 GeneID:5830,Genbank:NM_001351124.1,HGNC:HGNC:9719,MIM:600414 peroxisomal biogenesis factor 5 GO:0000268,GO:0005052,GO:0005622,GO:0005737,GO:0005777,GO:0005778,GO:0005782,GO:0005794,GO:0005829,GO:0006625,GO:0008022,GO:0016020,GO:0016558,GO:0016560,GO:0016561,GO:0016567,GO:0019899,GO:0031267,GO:0043234,GO:0045046,GO:0047485,GO:0051262,GO:1901094 peroxisome targeting sequence binding|peroxisome matrix targeting signal-1 binding|intracellular|cytoplasm|peroxisome|peroxisomal membrane|peroxisomal matrix|Golgi apparatus|cytosol|protein targeting to peroxisome|protein C-terminus binding|membrane|protein import into peroxisome matrix|protein import into peroxisome matrix, docking|protein import into peroxisome matrix, translocation|protein ubiquitination|enzyme binding|small GTPase binding|protein complex|protein import into peroxisome membrane|protein N-terminus binding|protein tetramerization|negative regulation of protein homotetramerization hsa04146 Peroxisome PEX5L 18.0564750612271 18.6609308939568 17.4520192284974 0.935216968953521 -0.0966269879401679 0.909315546219892 1 0.0372001 0.0896663 0.0752657 0.0300567 GeneID:51555,Genbank:NM_001349404.1,HGNC:HGNC:30024,MIM:611058 peroxisomal biogenesis factor 5 like GO:0000268,GO:0005052,GO:0005778,GO:0005829,GO:0016560,GO:0031267,GO:0043235,GO:0043949 peroxisome targeting sequence binding|peroxisome matrix targeting signal-1 binding|peroxisomal membrane|cytosol|protein import into peroxisome matrix, docking|small GTPase binding|receptor complex|regulation of cAMP-mediated signaling hsa04146 Peroxisome PEX6 821.122453770284 763.181839315664 879.063068224904 1.1518396048485 0.203939833620181 0.207586856879174 1 6.67045 7.42256 7.82535 8.44298 GeneID:5190,Genbank:NM_001316313.1,HGNC:HGNC:8859,MIM:601498 peroxisomal biogenesis factor 6 hsa04146 Peroxisome PEX7 146.492465688886 139.840803344663 153.144128033109 1.09513192408984 0.131104673265703 0.622756766861868 1 1.96791 1.96947 2.32113 2.01528 GeneID:5191,Genbank:XM_017010934.2,HGNC:HGNC:8860,MIM:601757 peroxisomal biogenesis factor 7 GO:0001764,GO:0001958,GO:0005053,GO:0005777,GO:0005782,GO:0005829,GO:0006635,GO:0007031,GO:0008611,GO:0016558,GO:0019899,GO:0042803 neuron migration|endochondral ossification|peroxisome matrix targeting signal-2 binding|peroxisome|peroxisomal matrix|cytosol|fatty acid beta-oxidation|peroxisome organization|ether lipid biosynthetic process|protein import into peroxisome matrix|enzyme binding|protein homodimerization activity hsa04146 Peroxisome PFAS 1953.73734240661 2069.303578716 1838.17110609722 0.888304222253271 -0.170874246272175 0.220497792945527 1 14.3119 14.4329 12.9908 12.4994 GeneID:5198,Genbank:XM_024450804.1,HGNC:HGNC:8863,MIM:602133 phosphoribosylformylglycinamidine synthase GO:0004642,GO:0005524,GO:0005737,GO:0005829,GO:0006189,GO:0006541,GO:0009168,GO:0042493,GO:0046872,GO:0070062 phosphoribosylformylglycinamidine synthase activity|ATP binding|cytoplasm|cytosol|'de novo' IMP biosynthetic process|glutamine metabolic process|purine ribonucleoside monophosphate biosynthetic process|response to drug|metal ion binding|extracellular exosome hsa00230 Purine metabolism PFDN1 2048.62191381655 2033.78913205761 2063.45469557549 1.01458635167741 0.0208916584264024 0.900248623620111 1 31.353 35.9478 34.3909 35.9197 GeneID:5201,Genbank:NM_002622.4,HGNC:HGNC:8866,MIM:604897 prefoldin subunit 1 GO:0003700,GO:0005737,GO:0007010,GO:0007049,GO:0016272,GO:0044183,GO:0051082 DNA binding transcription factor activity|cytoplasm|cytoskeleton organization|cell cycle|prefoldin complex|protein binding involved in protein folding|unfolded protein binding PFDN2 1294.09425946845 1413.47476839261 1174.71375054429 0.831082221496008 -0.266936880615441 0.0685949975836136 0.918202374283561 47.1476 45.8548 40.4676 38.2131 GeneID:5202,Genbank:NM_012394.3,HGNC:HGNC:8867,MIM:613466 prefoldin subunit 2 GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006457,GO:0016272,GO:0044183,GO:0051082,GO:0051495,GO:0070062 nucleus|cytoplasm|mitochondrion|cytosol|protein folding|prefoldin complex|protein binding involved in protein folding|unfolded protein binding|positive regulation of cytoskeleton organization|extracellular exosome PFDN4 422.496574615882 480.087316121143 364.90583311062 0.760082220165427 -0.395772607635032 0.0321388985299329 0.7109621531152 11.0688 9.09298 7.31936 8.40048 GeneID:5203,Genbank:NM_002623.3,HGNC:HGNC:8868,MIM:604898 prefoldin subunit 4 GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006457,GO:0016272,GO:0051082,GO:0051087 nucleus|cytoplasm|mitochondrion|cytosol|protein folding|prefoldin complex|unfolded protein binding|chaperone binding PFDN5 2837.04392947811 2921.72643946259 2752.36141949364 0.942032553875886 -0.0861511788881563 0.687951066731002 1 134.555 153.494 119.715 149.668 GeneID:5204,Genbank:NM_002624.3,HGNC:HGNC:8869,MIM:604899 prefoldin subunit 5 GO:0003714,GO:0005634,GO:0005737,GO:0006355,GO:0006457,GO:0016272,GO:0045892,GO:0051082,GO:0060041,GO:0090090 transcription corepressor activity|nucleus|cytoplasm|regulation of transcription, DNA-templated|protein folding|prefoldin complex|negative regulation of transcription, DNA-templated|unfolded protein binding|retina development in camera-type eye|negative regulation of canonical Wnt signaling pathway PFDN6 1581.4294757946 1657.29593584564 1505.56301574356 0.908445488328153 -0.138528147382426 0.491703211590146 1 66.6818 69.1987 57.9614 71.6617 GeneID:10471,Genbank:NM_014260.3,HGNC:HGNC:4926,MIM:605660 prefoldin subunit 6 GO:0005737,GO:0006457,GO:0016272,GO:0051082,GO:0051087,GO:0051131 cytoplasm|protein folding|prefoldin complex|unfolded protein binding|chaperone binding|chaperone-mediated protein complex assembly PFKFB1 9.3973564659857 8.12930007942745 10.665412852544 1.31197184854014 0.391736763852902 0.734568628568493 1 0.0267492 0.0739532 0.0762105 0.031585 GeneID:5207,Genbank:NM_001271805.1,HGNC:HGNC:8872,MIM:311790 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 GO:0003873,GO:0004331,GO:0005524,GO:0005829,GO:0006000,GO:0006003,GO:0006094,GO:0006096,GO:0019900,GO:0031100,GO:0032868,GO:0033133,GO:0033762,GO:0042594,GO:0042802,GO:0043540,GO:0045820,GO:0045821,GO:0051384,GO:0051591,GO:0070095 6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|ATP binding|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolytic process|kinase binding|animal organ regeneration|response to insulin|positive regulation of glucokinase activity|response to glucagon|response to starvation|identical protein binding|6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex|negative regulation of glycolytic process|positive regulation of glycolytic process|response to glucocorticoid|response to cAMP|fructose-6-phosphate binding hsa00051,hsa04152,hsa04922 Fructose and mannose metabolism|AMPK signaling pathway|Glucagon signaling pathway PFKFB2 201.155643017906 205.047691768606 197.263594267207 0.962037624348467 -0.0558347773998321 0.825304677197225 1 0.699716 0.643497 0.747811 0.545114 GeneID:5208,Genbank:XM_024447657.1,HGNC:HGNC:8873,MIM:171835 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 GO:0003873,GO:0004331,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006000,GO:0006003,GO:0006007,GO:0006089,GO:0006096,GO:0009749,GO:0019901,GO:0032024,GO:0033133,GO:0045821 6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|ATP binding|nucleus|nucleoplasm|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|glucose catabolic process|lactate metabolic process|glycolytic process|response to glucose|protein kinase binding|positive regulation of insulin secretion|positive regulation of glucokinase activity|positive regulation of glycolytic process hsa00051,hsa04152,hsa04919 Fructose and mannose metabolism|AMPK signaling pathway|Thyroid hormone signaling pathway PFKFB3 5813.11536892805 5152.06428531783 6474.16645253827 1.25661600748813 0.329543863182208 0.0127890327322199 0.46405612496835 37.242 36.9705 48.318 46.1146 GeneID:5209,Genbank:NM_001323016.1,HGNC:HGNC:8874,MIM:605319 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 GO:0003873,GO:0004331,GO:0005524,GO:0005654,GO:0005829,GO:0006000,GO:0006003,GO:0007420,GO:0045821 6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|ATP binding|nucleoplasm|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|brain development|positive regulation of glycolytic process hsa00051,hsa04066,hsa04152 Fructose and mannose metabolism|HIF-1 signaling pathway|AMPK signaling pathway PFKFB4 1584.20357827585 1567.24827640018 1601.15888015153 1.02163703368635 0.0308827278698578 0.833668837291546 1 7.89888 7.94637 8.06826 8.48744 GeneID:5210,Genbank:XM_011533829.2,HGNC:HGNC:8875,MIM:605320 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 GO:0003873,GO:0004331,GO:0005524,GO:0005829,GO:0006000,GO:0006003,GO:0045821 6-phosphofructo-2-kinase activity|fructose-2,6-bisphosphate 2-phosphatase activity|ATP binding|cytosol|fructose metabolic process|fructose 2,6-bisphosphate metabolic process|positive regulation of glycolytic process hsa00051,hsa04152 Fructose and mannose metabolism|AMPK signaling pathway PFKL 1871.8603721514 1491.79893181067 2251.92181249213 1.50953440471958 0.594103638569112 0.000109746273227043 0.0240780316712921 13.4538 13.3638 19.874 22.0024 GeneID:5211,Genbank:NM_001002021.2,HGNC:HGNC:8876,MIM:171860 phosphofructokinase, liver type GO:0003872,GO:0005524,GO:0005576,GO:0005829,GO:0005945,GO:0006002,GO:0006096,GO:0009749,GO:0016020,GO:0019900,GO:0030388,GO:0034774,GO:0042802,GO:0043312,GO:0046676,GO:0046872,GO:0051259,GO:0051289,GO:0061621,GO:0070061,GO:0070062,GO:0070095,GO:1904813 6-phosphofructokinase activity|ATP binding|extracellular region|cytosol|6-phosphofructokinase complex|fructose 6-phosphate metabolic process|glycolytic process|response to glucose|membrane|kinase binding|fructose 1,6-bisphosphate metabolic process|secretory granule lumen|identical protein binding|neutrophil degranulation|negative regulation of insulin secretion|metal ion binding|protein oligomerization|protein homotetramerization|canonical glycolysis|fructose binding|extracellular exosome|fructose-6-phosphate binding|ficolin-1-rich granule lumen hsa00010,hsa00030,hsa00051,hsa00052,hsa03018,hsa04066,hsa04152,hsa04922,hsa05230 Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|Galactose metabolism|RNA degradation|HIF-1 signaling pathway|AMPK signaling pathway|Glucagon signaling pathway|Central carbon metabolism in cancer PFKM 2619.16794178993 2464.87032498387 2773.465558596 1.12519735033694 0.170178060448988 0.220221522607866 1 14.8219 15.2013 17.2041 16.9919 GeneID:5213,Genbank:NM_001354741.1,HGNC:HGNC:8877,MIM:610681 phosphofructokinase, muscle GO:0003872,GO:0005524,GO:0005634,GO:0005829,GO:0005945,GO:0005980,GO:0006002,GO:0006096,GO:0008022,GO:0016324,GO:0019900,GO:0032024,GO:0042593,GO:0042802,GO:0042803,GO:0045944,GO:0046716,GO:0046872,GO:0051259,GO:0061615,GO:0061621,GO:0070061,GO:0070062,GO:0093001,GO:0097228 6-phosphofructokinase activity|ATP binding|nucleus|cytosol|6-phosphofructokinase complex|glycogen catabolic process|fructose 6-phosphate metabolic process|glycolytic process|protein C-terminus binding|apical plasma membrane|kinase binding|positive regulation of insulin secretion|glucose homeostasis|identical protein binding|protein homodimerization activity|positive regulation of transcription from RNA polymerase II promoter|muscle cell cellular homeostasis|metal ion binding|protein oligomerization|glycolytic process through fructose-6-phosphate|canonical glycolysis|fructose binding|extracellular exosome|glycolysis from storage polysaccharide through glucose-1-phosphate|sperm principal piece hsa00010,hsa00030,hsa00051,hsa00052,hsa03018,hsa04152,hsa05230 Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|Galactose metabolism|RNA degradation|AMPK signaling pathway|Central carbon metabolism in cancer PFKP 5715.52772141889 5847.37919079252 5583.67625204525 0.954902370764239 -0.0665748553664593 0.602896834964797 1 42.621 44.0233 41.0024 43.3393 GeneID:5214,Genbank:XM_005252465.4,HGNC:HGNC:8878,MIM:171840 phosphofructokinase, platelet GO:0003872,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006002,GO:0016020,GO:0031012,GO:0032403,GO:0042802,GO:0045296,GO:0046872,GO:0061621,GO:0070062,GO:1990830 6-phosphofructokinase activity|ATP binding|nucleus|cytoplasm|cytosol|fructose 6-phosphate metabolic process|membrane|extracellular matrix|protein complex binding|identical protein binding|cadherin binding|metal ion binding|canonical glycolysis|extracellular exosome|cellular response to leukemia inhibitory factor hsa00010,hsa00030,hsa00051,hsa00052,hsa03018,hsa04152,hsa04919,hsa05230 Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Fructose and mannose metabolism|Galactose metabolism|RNA degradation|AMPK signaling pathway|Thyroid hormone signaling pathway|Central carbon metabolism in cancer PFN1 34825.1672237263 35324.7260426794 34325.6084047731 0.971716195712343 -0.0413930802585243 0.739468476582448 1 661.828 715.349 665.328 715.329 GeneID:5216,Genbank:NM_005022.3,HGNC:HGNC:8881,MIM:176610 profilin 1 GO:0000774,GO:0001843,GO:0003723,GO:0003779,GO:0003785,GO:0005546,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0005938,GO:0006357,GO:0010634,GO:0016020,GO:0017048,GO:0030036,GO:0030837,GO:0030838,GO:0032232,GO:0032233,GO:0032781,GO:0045296,GO:0050821,GO:0051497,GO:0060071,GO:0070062,GO:0070064,GO:0072562,GO:1900029 adenyl-nucleotide exchange factor activity|neural tube closure|RNA binding|actin binding|actin monomer binding|phosphatidylinositol-4,5-bisphosphate binding|nucleus|cytoplasm|cytosol|cytoskeleton|focal adhesion|cell cortex|regulation of transcription from RNA polymerase II promoter|positive regulation of epithelial cell migration|membrane|Rho GTPase binding|actin cytoskeleton organization|negative regulation of actin filament polymerization|positive regulation of actin filament polymerization|negative regulation of actin filament bundle assembly|positive regulation of actin filament bundle assembly|positive regulation of ATPase activity|cadherin binding|protein stabilization|negative regulation of stress fiber assembly|Wnt signaling pathway, planar cell polarity pathway|extracellular exosome|proline-rich region binding|blood microparticle|positive regulation of ruffle assembly hsa04015,hsa04810,hsa05131,hsa05132 Rap1 signaling pathway|Regulation of actin cytoskeleton|Shigellosis|Salmonella infection PFN2 4971.27171072267 4617.6926794373 5324.85074200804 1.15314099739026 0.205568925651524 0.119974636609931 1 104.455 107.355 120.422 126.12 GeneID:5217,Genbank:NM_002628.4,HGNC:HGNC:8882,MIM:176590 profilin 2 GO:0003785,GO:0005546,GO:0005737,GO:0005856,GO:0010633,GO:0016887,GO:0030036,GO:0030837,GO:0030838,GO:0032233,GO:0032781,GO:0033138,GO:0043195,GO:0050821,GO:0051496,GO:0070062,GO:1900028,GO:2000300 actin monomer binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|cytoskeleton|negative regulation of epithelial cell migration|ATPase activity|actin cytoskeleton organization|negative regulation of actin filament polymerization|positive regulation of actin filament polymerization|positive regulation of actin filament bundle assembly|positive regulation of ATPase activity|positive regulation of peptidyl-serine phosphorylation|terminal bouton|protein stabilization|positive regulation of stress fiber assembly|extracellular exosome|negative regulation of ruffle assembly|regulation of synaptic vesicle exocytosis hsa04015,hsa04810,hsa05131,hsa05132 Rap1 signaling pathway|Regulation of actin cytoskeleton|Shigellosis|Salmonella infection PFN4 15.0591024011875 11.7038787171838 18.4143260851911 1.57335243556095 0.653841874875551 0.39854875114833 1 0.127888 0.212899 0.260747 0.242833 GeneID:375189,Genbank:NM_199346.2,HGNC:HGNC:31103 profilin family member 4 GO:0003785,GO:0005938,GO:0008289,GO:0015629,GO:0042989 actin monomer binding|cell cortex|lipid binding|actin cytoskeleton|sequestering of actin monomers hsa04015,hsa04810,hsa05131,hsa05132 Rap1 signaling pathway|Regulation of actin cytoskeleton|Shigellosis|Salmonella infection PGAM1 12676.9811409688 12534.7823274561 12819.1799544815 1.0226886769627 0.0323670321228479 0.814416567333256 1 216.593 221.676 217.611 232.232 GeneID:5223,Genbank:NM_002629.3,HGNC:HGNC:8888,MIM:172250 phosphoglycerate mutase 1 GO:0004082,GO:0004619,GO:0005576,GO:0005737,GO:0005829,GO:0006094,GO:0006096,GO:0006110,GO:0016020,GO:0016787,GO:0019901,GO:0034774,GO:0043312,GO:0043456,GO:0045730,GO:0046538,GO:0061621,GO:0070062,GO:1904813 bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|extracellular region|cytoplasm|cytosol|gluconeogenesis|glycolytic process|regulation of glycolytic process|membrane|hydrolase activity|protein kinase binding|secretory granule lumen|neutrophil degranulation|regulation of pentose-phosphate shunt|respiratory burst|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity|canonical glycolysis|extracellular exosome|ficolin-1-rich granule lumen hsa00010,hsa00260,hsa04922,hsa05230 Glycolysis / Gluconeogenesis|Glycine, serine and threonine metabolism|Glucagon signaling pathway|Central carbon metabolism in cancer PGAM2 2.7001550562055 2.00831188251439 3.3919982298966 1.68897981405649 0.75615208578606 0.793445095465878 1 0 0 0 0.0972351 GeneID:5224,Genbank:NM_000290.3,HGNC:HGNC:8889,MIM:612931 phosphoglycerate mutase 2 GO:0004082,GO:0004619,GO:0005634,GO:0005829,GO:0006094,GO:0006096,GO:0006941,GO:0007219,GO:0007283,GO:0016787,GO:0043456,GO:0046538,GO:0046689,GO:0048037,GO:0061621,GO:0070062 bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|nucleus|cytosol|gluconeogenesis|glycolytic process|striated muscle contraction|Notch signaling pathway|spermatogenesis|hydrolase activity|regulation of pentose-phosphate shunt|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity|response to mercury ion|cofactor binding|canonical glycolysis|extracellular exosome hsa00010,hsa00260,hsa04922,hsa05230 Glycolysis / Gluconeogenesis|Glycine, serine and threonine metabolism|Glucagon signaling pathway|Central carbon metabolism in cancer PGAM4 77.9036875868579 74.8740462941438 80.933328879572 1.08092634077267 0.112268214633438 0.775451716906713 1 1.64219 2.16524 2.17761 2.0509 GeneID:441531,Genbank:NM_001029891.2,HGNC:HGNC:21731,MIM:300567 phosphoglycerate mutase family member 4 GO:0004082,GO:0004619,GO:0005829,GO:0006094,GO:0006096,GO:0016787,GO:0043456,GO:0046538,GO:0070062,GO:0097228,GO:1902093 bisphosphoglycerate mutase activity|phosphoglycerate mutase activity|cytosol|gluconeogenesis|glycolytic process|hydrolase activity|regulation of pentose-phosphate shunt|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity|extracellular exosome|sperm principal piece|positive regulation of flagellated sperm motility hsa00010,hsa00260,hsa04922,hsa05230 Glycolysis / Gluconeogenesis|Glycine, serine and threonine metabolism|Glucagon signaling pathway|Central carbon metabolism in cancer PGAM5 1880.43744128179 1960.07752501101 1800.79735755257 0.918737822649366 -0.122274872031732 0.379095588193001 1 26.1915 26.4375 24.5127 25.4668 GeneID:192111,Genbank:NM_001170543.1,HGNC:HGNC:28763,MIM:614939 PGAM family member 5, mitochondrial serine/threonine protein phosphatase GO:0004722,GO:0005096,GO:0005739,GO:0005741,GO:0009400,GO:0016021,GO:0016236,GO:0016791,GO:0032403,GO:0070266 protein serine/threonine phosphatase activity|GTPase activator activity|mitochondrion|mitochondrial outer membrane|signal transducer, downstream of receptor, with serine/threonine phosphatase activity|integral component of membrane|macroautophagy|phosphatase activity|protein complex binding|necroptotic process hsa04137,hsa04217,hsa04668 Mitophagy - animal|Necroptosis|TNF signaling pathway PGAP1 156.25061419229 167.57194250153 144.929285883049 0.864877996396839 -0.2094314608748 0.601063424766334 1 0.731025 0.538353 0.65541 0.428351 GeneID:80055,Genbank:NM_001321100.1,HGNC:HGNC:25712,MIM:611655 post-GPI attachment to proteins 1 GO:0004518,GO:0005783,GO:0005789,GO:0007605,GO:0009880,GO:0009948,GO:0015031,GO:0015798,GO:0016021,GO:0016255,GO:0016788,GO:0021871,GO:0042578 nuclease activity|endoplasmic reticulum|endoplasmic reticulum membrane|sensory perception of sound|embryonic pattern specification|anterior/posterior axis specification|protein transport|myo-inositol transport|integral component of membrane|attachment of GPI anchor to protein|hydrolase activity, acting on ester bonds|forebrain regionalization|phosphoric ester hydrolase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PGAP2 330.920960743345 340.535687425445 321.306234061246 0.943531752840414 -0.0838570249741272 0.670634331854227 1 2.80491 2.8252 2.7821 2.56472 GeneID:27315,Genbank:NM_001256235.1,HGNC:HGNC:17893,MIM:615187 post-GPI attachment to proteins 2 GO:0000139,GO:0005634,GO:0005789,GO:0006506,GO:0008565,GO:0016021,GO:0042770,GO:0042771,GO:1902230 Golgi membrane|nucleus|endoplasmic reticulum membrane|GPI anchor biosynthetic process|protein transporter activity|integral component of membrane|signal transduction in response to DNA damage|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage PGAP3 244.357084359228 219.759642482435 268.95452623602 1.22385768013578 0.291435799778741 0.180589894965449 1 3.00997 3.22019 3.32958 3.67569 GeneID:93210,Genbank:NM_001291726.1,HGNC:HGNC:23719,MIM:611801 post-GPI attachment to proteins 3 GO:0000139,GO:0006505,GO:0006506,GO:0016021,GO:0016788,GO:0031227 Golgi membrane|GPI anchor metabolic process|GPI anchor biosynthetic process|integral component of membrane|hydrolase activity, acting on ester bonds|intrinsic component of endoplasmic reticulum membrane PGBD1 318.097719370119 337.633476633278 298.561962106959 0.884278315894734 -0.177427583000358 0.376130382067283 1 2.22008 2.08886 2.13249 1.59055 GeneID:84547,Genbank:NM_001184743.1,HGNC:HGNC:19398 piggyBac transposable element derived 1 GO:0003700,GO:0005044,GO:0016020,GO:0042802 DNA binding transcription factor activity|scavenger receptor activity|membrane|identical protein binding PGBD2 69.5458017616335 72.2217755305093 66.8698279927577 0.925895652683162 -0.111078482221644 0.763082570966217 1 0.894446 0.981246 0.78244 1.00057 GeneID:267002,Genbank:XM_011544161.3,HGNC:HGNC:19399 piggyBac transposable element derived 2 PGBD4 67.6425816747694 73.7302073559584 61.5549559935804 0.834867528534163 -0.260380796807918 0.482907205864347 1 1.40364 1.16231 1.26998 0.848127 GeneID:161779,Genbank:NM_152595.4,HGNC:HGNC:19401 piggyBac transposable element derived 4 PGBD5 152.430231353621 144.453359716127 160.407102991116 1.11044217528994 0.151134268531461 0.575425839962272 1 1.10591 1.40437 1.46839 1.43919 GeneID:79605,Genbank:NM_001258311.1,HGNC:HGNC:19405,MIM:616791 piggyBac transposable element derived 5 GO:0004519,GO:0005634,GO:0032196 endonuclease activity|nucleus|transposition PGD 8852.07862840889 8736.39225683524 8967.76499998254 1.02648378602349 0.0377108393235267 0.780670930131939 1 125.449 128.784 131.4 135.482 GeneID:5226,Genbank:NM_002631.3,HGNC:HGNC:8891,MIM:172200 phosphogluconate dehydrogenase GO:0004616,GO:0005634,GO:0005829,GO:0006098,GO:0009051,GO:0019322,GO:0019521,GO:0055114,GO:0070062 phosphogluconate dehydrogenase (decarboxylating) activity|nucleus|cytosol|pentose-phosphate shunt|pentose-phosphate shunt, oxidative branch|pentose biosynthetic process|D-gluconate metabolic process|oxidation-reduction process|extracellular exosome hsa00030,hsa00480 Pentose phosphate pathway|Glutathione metabolism PGF 34.5929601031314 35.7457863775636 33.4401338286992 0.935498620046822 -0.0961925695378989 0.860256856701501 1 0.791732 0.822718 0.854973 0.754139 GeneID:5228,Genbank:NM_001293643.1,HGNC:HGNC:8893,MIM:601121 placental growth factor GO:0001525,GO:0001658,GO:0001666,GO:0001938,GO:0002040,GO:0005172,GO:0005576,GO:0005615,GO:0007165,GO:0007267,GO:0007565,GO:0008083,GO:0008201,GO:0008284,GO:0016020,GO:0030154,GO:0031100,GO:0032870,GO:0042493,GO:0042803,GO:0045766,GO:0046982,GO:0048010,GO:0050930,GO:0051781,GO:0060688,GO:0060754 angiogenesis|branching involved in ureteric bud morphogenesis|response to hypoxia|positive regulation of endothelial cell proliferation|sprouting angiogenesis|vascular endothelial growth factor receptor binding|extracellular region|extracellular space|signal transduction|cell-cell signaling|female pregnancy|growth factor activity|heparin binding|positive regulation of cell proliferation|membrane|cell differentiation|animal organ regeneration|cellular response to hormone stimulus|response to drug|protein homodimerization activity|positive regulation of angiogenesis|protein heterodimerization activity|vascular endothelial growth factor receptor signaling pathway|induction of positive chemotaxis|positive regulation of cell division|regulation of morphogenesis of a branching structure|positive regulation of mast cell chemotaxis hsa04010,hsa04014,hsa04015,hsa04151,hsa04510,hsa05200 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Pathways in cancer PGGHG 73.4821783931068 62.6320699003177 84.3322868858958 1.3464713368106 0.429183518602047 0.221372468561814 1 0.400318 0.454205 0.72796 0.607802 GeneID:80162,Genbank:XM_011520383.2,HGNC:HGNC:26210,MIM:617032 protein-glucosylgalactosylhydroxylysine glucosidase GO:0005618,GO:0005829,GO:0005975,GO:0047402 cell wall|cytosol|carbohydrate metabolic process|protein-glucosylgalactosylhydroxylysine glucosidase activity PGGT1B 360.888917946025 382.517114858653 339.260721033398 0.88691644858495 -0.17312989215317 0.378385872375315 1 1.03966 0.922597 0.971844 0.807876 GeneID:5229,Genbank:XM_005272020.3,HGNC:HGNC:8895,MIM:602031 protein geranylgeranyltransferase type I subunit beta GO:0004661,GO:0004662,GO:0005953,GO:0008144,GO:0008270,GO:0008284,GO:0018344,GO:0019840,GO:0034097,GO:0042277,GO:0045787,GO:0051771 protein geranylgeranyltransferase activity|CAAX-protein geranylgeranyltransferase activity|CAAX-protein geranylgeranyltransferase complex|drug binding|zinc ion binding|positive regulation of cell proliferation|protein geranylgeranylation|isoprenoid binding|response to cytokine|peptide binding|positive regulation of cell cycle|negative regulation of nitric-oxide synthase biosynthetic process PGK1 24258.4322515687 23274.4538109129 25242.4106922245 1.08455437439262 0.117102384683864 0.511715679720219 1 395.443 423.563 411.791 481.381 GeneID:5230,Genbank:NM_000291.3,HGNC:HGNC:8896,MIM:311800 phosphoglycerate kinase 1 hsa00010,hsa04066 Glycolysis / Gluconeogenesis|HIF-1 signaling pathway PGK2 1.02316597922947 1.07619535328461 0.97013660517434 0.901450282435646 -0.149680169798226 1 1 0.0513285 0 0.0490513 0 GeneID:5232,Genbank:NM_138733.4,HGNC:HGNC:8898,MIM:172270 phosphoglycerate kinase 2 hsa00010 Glycolysis / Gluconeogenesis PGLS 1366.5276296837 1262.27709590952 1470.77816345788 1.16517852397387 0.220551015755051 0.139473339866236 1 26.1806 28.6707 30.3837 33.9344 GeneID:25796,Genbank:NM_012088.2,HGNC:HGNC:8903,MIM:604951 6-phosphogluconolactonase GO:0005737,GO:0005829,GO:0005975,GO:0006098,GO:0009051,GO:0017057,GO:0070062 cytoplasm|cytosol|carbohydrate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, oxidative branch|6-phosphogluconolactonase activity|extracellular exosome hsa00030 Pentose phosphate pathway PGM1 2325.66746989142 2244.77551557949 2406.55942420334 1.0720713084676 0.100400869369486 0.483270384375473 1 22.3359 24.9146 25.1662 26.0455 GeneID:5236,Genbank:NM_002633.2,HGNC:HGNC:8905,MIM:171900 phosphoglucomutase 1 GO:0000287,GO:0004614,GO:0005576,GO:0005737,GO:0005829,GO:0005978,GO:0005980,GO:0006006,GO:0006094,GO:0006096,GO:0015629,GO:0019388,GO:0043312,GO:0070062,GO:1904724,GO:1904813 magnesium ion binding|phosphoglucomutase activity|extracellular region|cytoplasm|cytosol|glycogen biosynthetic process|glycogen catabolic process|glucose metabolic process|gluconeogenesis|glycolytic process|actin cytoskeleton|galactose catabolic process|neutrophil degranulation|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen hsa00010,hsa00030,hsa00052,hsa00230,hsa00500,hsa00520 Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Galactose metabolism|Purine metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism PGM2 1093.44476347371 1228.74727582001 958.142251127414 0.779771617795038 -0.358876450553883 0.0377126941455529 0.744558420459959 15.5213 13.0647 12.1437 10.7098 GeneID:55276,Genbank:NM_018290.3,HGNC:HGNC:8906,MIM:172000 phosphoglucomutase 2 GO:0000287,GO:0004614,GO:0005576,GO:0005829,GO:0005978,GO:0005980,GO:0006006,GO:0006098,GO:0008973,GO:0019388,GO:0034774,GO:0043312,GO:0046386,GO:0070062,GO:1904813 magnesium ion binding|phosphoglucomutase activity|extracellular region|cytosol|glycogen biosynthetic process|glycogen catabolic process|glucose metabolic process|pentose-phosphate shunt|phosphopentomutase activity|galactose catabolic process|secretory granule lumen|neutrophil degranulation|deoxyribose phosphate catabolic process|extracellular exosome|ficolin-1-rich granule lumen hsa00010,hsa00030,hsa00052,hsa00230,hsa00500,hsa00520 Glycolysis / Gluconeogenesis|Pentose phosphate pathway|Galactose metabolism|Purine metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism PGM2L1 990.250301616561 1030.00286869195 950.497734541174 0.92281076435084 -0.115893262100753 0.712247850109752 1 5.15588 4.18603 5.14794 3.51899 GeneID:283209,Genbank:NM_173582.4,HGNC:HGNC:20898,MIM:611610 phosphoglucomutase 2 like 1 GO:0004614,GO:0005829,GO:0005978,GO:0005980,GO:0019388,GO:0046872,GO:0047933,GO:0061621 phosphoglucomutase activity|cytosol|glycogen biosynthetic process|glycogen catabolic process|galactose catabolic process|metal ion binding|glucose-1,6-bisphosphate synthase activity|canonical glycolysis hsa00500 Starch and sucrose metabolism PGM3 855.667570348151 873.357592858389 837.977547837912 0.959489623368725 -0.0596608907548066 0.72049826809616 1 4.38011 4.30501 4.71241 3.83899 GeneID:5238,Genbank:NM_001199917.1,HGNC:HGNC:8907,MIM:172100 phosphoglucomutase 3 GO:0000287,GO:0004610,GO:0004614,GO:0005829,GO:0005975,GO:0006041,GO:0006048,GO:0006487,GO:0006493,GO:0007283,GO:0019255,GO:0030097 magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity|cytosol|carbohydrate metabolic process|glucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|protein N-linked glycosylation|protein O-linked glycosylation|spermatogenesis|glucose 1-phosphate metabolic process|hemopoiesis hsa00520 Amino sugar and nucleotide sugar metabolism PGM5 74.1638715945339 50.9281911831339 97.3995520059339 1.9124879510386 0.935450658638431 0.00658564868832238 0.320671396500742 0.206445 0.300965 0.504938 0.585618 GeneID:5239,Genbank:XM_011518783.3,HGNC:HGNC:8908,MIM:600981 phosphoglucomutase 5 GO:0000287,GO:0001725,GO:0005198,GO:0005913,GO:0005914,GO:0005925,GO:0005975,GO:0007155,GO:0009898,GO:0014704,GO:0016010,GO:0016868,GO:0030018,GO:0042383,GO:0043034 magnesium ion binding|stress fiber|structural molecule activity|cell-cell adherens junction|spot adherens junction|focal adhesion|carbohydrate metabolic process|cell adhesion|cytoplasmic side of plasma membrane|intercalated disc|dystrophin-associated glycoprotein complex|intramolecular transferase activity, phosphotransferases|Z disc|sarcolemma|costamere PGP 1151.61181415238 1167.31012213513 1135.91350616963 0.973103449229015 -0.0393349108919155 0.780888087698228 1 19.6343 20.6434 19.2594 20.3294 GeneID:283871,Genbank:NM_001042371.2,HGNC:HGNC:8909,MIM:172280 phosphoglycolate phosphatase GO:0000121,GO:0000287,GO:0004721,GO:0004725,GO:0005829,GO:0006114,GO:0006650,GO:0008967,GO:0016311,GO:0035335,GO:0043136,GO:0045721,GO:0098519 glycerol-1-phosphatase activity|magnesium ion binding|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|cytosol|glycerol biosynthetic process|glycerophospholipid metabolic process|phosphoglycolate phosphatase activity|dephosphorylation|peptidyl-tyrosine dephosphorylation|glycerol-3-phosphatase activity|negative regulation of gluconeogenesis|nucleotide phosphatase activity, acting on free nucleotides hsa00630 Glyoxylate and dicarboxylate metabolism PGPEP1 1509.87108442804 1399.75175213695 1619.99041671914 1.15734123157621 0.210814292726806 0.161806846747775 1 7.72176 7.0528 8.16685 8.98079 GeneID:54858,Genbank:XM_006722783.3,HGNC:HGNC:13568,MIM:610694 pyroglutamyl-peptidase I GO:0005829,GO:0006508,GO:0008233,GO:0008234,GO:0016920 cytosol|proteolysis|peptidase activity|cysteine-type peptidase activity|pyroglutamyl-peptidase activity PGPEP1L 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0243155 0 GeneID:145814,Genbank:NM_001167902.1,HGNC:HGNC:27080 pyroglutamyl-peptidase I like GO:0005829,GO:0006508,GO:0008234 cytosol|proteolysis|cysteine-type peptidase activity PGRMC1 4434.12732172484 4675.61308941422 4192.64155403547 0.896704127107477 -0.157296057087983 0.249048590931587 1 125.319 116.875 115.502 103.5 GeneID:10857,Genbank:NM_006667.4,HGNC:HGNC:16090,MIM:300435 progesterone receptor membrane component 1 GO:0005496,GO:0005783,GO:0005886,GO:0005887,GO:0016020,GO:0020037,GO:0030868,GO:0035579,GO:0043005,GO:0043025,GO:0043312,GO:0044297,GO:0045202,GO:0070062 steroid binding|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|membrane|heme binding|smooth endoplasmic reticulum membrane|specific granule membrane|neuron projection|neuronal cell body|neutrophil degranulation|cell body|synapse|extracellular exosome PGRMC2 1571.64921159466 1541.58226705477 1601.71615613455 1.03900790140423 0.0552066256312993 0.702498520784407 1 15.2719 15.7659 16.442 15.1209 GeneID:10424,Genbank:NM_006320.4,HGNC:HGNC:16089,MIM:607735 progesterone receptor membrane component 2 GO:0003707,GO:0005496,GO:0005635,GO:0016020,GO:0016021,GO:0020037 steroid hormone receptor activity|steroid binding|nuclear envelope|membrane|integral component of membrane|heme binding PGS1 791.46373342104 786.656223334077 796.271243508003 1.01222264553273 0.0175266559187711 0.928292758900502 1 4.37226 4.7146 5.18005 4.3858 GeneID:9489,Genbank:NM_024419.4,HGNC:HGNC:30029,MIM:614942 phosphatidylglycerophosphate synthase 1 GO:0005509,GO:0005524,GO:0005739,GO:0005743,GO:0005783,GO:0006655,GO:0008444,GO:0017169,GO:0032049,GO:0046339 calcium ion binding|ATP binding|mitochondrion|mitochondrial inner membrane|endoplasmic reticulum|phosphatidylglycerol biosynthetic process|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity|CDP-alcohol phosphatidyltransferase activity|cardiolipin biosynthetic process|diacylglycerol metabolic process hsa00564 Glycerophospholipid metabolism PHACTR1 50.8091164714252 49.7559432804794 51.8622896623709 1.04233356345026 0.0598170370469204 0.938204244040034 1 0.176173 0.297841 0.273877 0.205441 GeneID:221692,Genbank:XM_017010457.2,HGNC:HGNC:20990,MIM:608723 phosphatase and actin regulator 1 GO:0003779,GO:0004864,GO:0005634,GO:0005829,GO:0008157,GO:0030054,GO:0031032,GO:0031532,GO:0043149,GO:0045202,GO:0048870 actin binding|protein phosphatase inhibitor activity|nucleus|cytosol|protein phosphatase 1 binding|cell junction|actomyosin structure organization|actin cytoskeleton reorganization|stress fiber assembly|synapse|cell motility PHACTR2 199.129114243536 195.658882891407 202.599345595665 1.03547225968836 0.0502889042623231 0.873346393778836 1 0.878619 0.564435 0.879561 0.637176 GeneID:9749,Genbank:NM_014721.2,HGNC:HGNC:20956,MIM:608724 phosphatase and actin regulator 2 GO:0002576,GO:0003779,GO:0004864,GO:0005886,GO:0031092 platelet degranulation|actin binding|protein phosphatase inhibitor activity|plasma membrane|platelet alpha granule membrane PHACTR4 1795.36775970882 1901.76883683319 1688.96668258444 0.888103038535902 -0.17120102578834 0.22643112423006 1 8.41503 8.81051 7.98368 7.23375 GeneID:65979,Genbank:NM_001350159.1,HGNC:HGNC:25793,MIM:608726 phosphatase and actin regulator 4 GO:0001755,GO:0001843,GO:0003779,GO:0005737,GO:0007266,GO:0008157,GO:0030027,GO:0030036,GO:0043085,GO:0048484,GO:0051726,GO:0061386,GO:0072542,GO:2001045 neural crest cell migration|neural tube closure|actin binding|cytoplasm|Rho protein signal transduction|protein phosphatase 1 binding|lamellipodium|actin cytoskeleton organization|positive regulation of catalytic activity|enteric nervous system development|regulation of cell cycle|closure of optic fissure|protein phosphatase activator activity|negative regulation of integrin-mediated signaling pathway PHAX 1239.72591131064 1338.56148747803 1140.89033514325 0.852325683815081 -0.230523288094161 0.121802953977619 1 12.7168 12.8642 12.145 10.0107 GeneID:51808,Genbank:NM_032177.3,HGNC:HGNC:10241,MIM:604924 phosphorylated adaptor for RNA export GO:0003723,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0006408,GO:0015030,GO:0015031,GO:0015643,GO:0042795,GO:0043025,GO:0051168 RNA binding|nucleus|nucleoplasm|centrosome|cytosol|snRNA export from nucleus|Cajal body|protein transport|toxic substance binding|snRNA transcription from RNA polymerase II promoter|neuronal cell body|nuclear export hsa03013 RNA transport PHB 6044.9716629467 6230.7530039421 5859.19032195129 0.940366327832971 -0.0887052142738403 0.535349956838617 1 105.577 114.321 98.2562 110.416 GeneID:5245,Genbank:NM_001281497.1,HGNC:HGNC:8912,MIM:176705 prohibitin GO:0000122,GO:0000981,GO:0001649,GO:0001850,GO:0001851,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005769,GO:0005886,GO:0005887,GO:0006355,GO:0006851,GO:0007005,GO:0007165,GO:0008022,GO:0008285,GO:0009986,GO:0010628,GO:0010942,GO:0010944,GO:0016020,GO:0016575,GO:0019899,GO:0030308,GO:0031871,GO:0042177,GO:0042826,GO:0042981,GO:0043209,GO:0044212,GO:0045745,GO:0045892,GO:0045893,GO:0045917,GO:0050821,GO:0050847,GO:0060766,GO:0070062,GO:0070373,GO:0070374,GO:0071354,GO:0071897,GO:2000323 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|osteoblast differentiation|complement component C3a binding|complement component C3b binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|early endosome|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|mitochondrial calcium ion transmembrane transport|mitochondrion organization|signal transduction|protein C-terminus binding|negative regulation of cell proliferation|cell surface|positive regulation of gene expression|positive regulation of cell death|negative regulation of transcription by competitive promoter binding|membrane|histone deacetylation|enzyme binding|negative regulation of cell growth|proteinase activated receptor binding|negative regulation of protein catabolic process|histone deacetylase binding|regulation of apoptotic process|myelin sheath|transcription regulatory region DNA binding|positive regulation of G-protein coupled receptor protein signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of complement activation|protein stabilization|progesterone receptor signaling pathway|negative regulation of androgen receptor signaling pathway|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to interleukin-6|DNA biosynthetic process|negative regulation of glucocorticoid receptor signaling pathway PHB2 4370.07931053608 4498.0665754376 4242.09204563455 0.943092320776033 -0.0845290894096655 0.607106421247058 1 91.4954 101.478 81.8286 96.5495 GeneID:11331,Genbank:NM_001267700.1,HGNC:HGNC:30306,MIM:610704 prohibitin 2 GO:0000060,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0006351,GO:0006851,GO:0007005,GO:0007062,GO:0008022,GO:0009611,GO:0009986,GO:0016363,GO:0030331,GO:0030424,GO:0031536,GO:0033147,GO:0033218,GO:0033600,GO:0043066,GO:0043234,GO:0043433,GO:0045892,GO:0047485,GO:0050821,GO:0051091,GO:0060744,GO:0060749,GO:0060762,GO:0070062,GO:0070374,GO:0071300,GO:0071456,GO:0071944,GO:1902808 protein import into nucleus, translocation|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|transcription, DNA-templated|mitochondrial calcium ion transmembrane transport|mitochondrion organization|sister chromatid cohesion|protein C-terminus binding|response to wounding|cell surface|nuclear matrix|estrogen receptor binding|axon|positive regulation of exit from mitosis|negative regulation of intracellular estrogen receptor signaling pathway|amide binding|negative regulation of mammary gland epithelial cell proliferation|negative regulation of apoptotic process|protein complex|negative regulation of DNA binding transcription factor activity|negative regulation of transcription, DNA-templated|protein N-terminus binding|protein stabilization|positive regulation of DNA binding transcription factor activity|mammary gland branching involved in thelarche|mammary gland alveolus development|regulation of branching involved in mammary gland duct morphogenesis|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to retinoic acid|cellular response to hypoxia|cell periphery|positive regulation of cell cycle G1/S phase transition PHC1 473.679915455541 507.320609222655 440.039221688427 0.867378958569573 -0.205265649075705 0.239370417766268 1 2.85537 3.12979 2.63751 2.55564 GeneID:1911,Genbank:XM_011520603.2,HGNC:HGNC:3182,MIM:602978 polyhomeotic homolog 1 GO:0003677,GO:0005634,GO:0005654,GO:0007275,GO:0008270,GO:0016574,GO:0031519,GO:0035102,GO:0070317 DNA binding|nucleus|nucleoplasm|multicellular organism development|zinc ion binding|histone ubiquitination|PcG protein complex|PRC1 complex|negative regulation of G0 to G1 transition PHC2 4233.48055358028 4107.75532742146 4359.20577973909 1.06121359045877 0.0857150567082037 0.543903108905948 1 38.9946 41.9908 44.6634 43.1784 GeneID:1912,Genbank:NM_001330488.1,HGNC:HGNC:3183,MIM:602979 polyhomeotic homolog 2 GO:0000792,GO:0003677,GO:0005634,GO:0005654,GO:0007275,GO:0007283,GO:0008270,GO:0031519,GO:0035102,GO:0042802 heterochromatin|DNA binding|nucleus|nucleoplasm|multicellular organism development|spermatogenesis|zinc ion binding|PcG protein complex|PRC1 complex|identical protein binding PHC3 340.475954442156 365.373407444398 315.578501439913 0.863715024164524 -0.211372709630805 0.728159587257079 1 1.32156 0.861628 1.26908 0.636257 GeneID:80012,Genbank:XM_017007236.2,HGNC:HGNC:15682 polyhomeotic homolog 3 GO:0003677,GO:0005634,GO:0005654,GO:0007275,GO:0008270,GO:0031519,GO:0035102,GO:0070317 DNA binding|nucleus|nucleoplasm|multicellular organism development|zinc ion binding|PcG protein complex|PRC1 complex|negative regulation of G0 to G1 transition PHETA1 165.562011978648 128.060489388325 203.063534568971 1.58568451158429 0.665105760418584 0.00770904770070052 0.342738246075193 1.23807 1.76551 2.51667 2.3197 GeneID:144717,Genbank:NM_001177997.1,HGNC:HGNC:26509,MIM:614239 PH domain containing endocytic trafficking adaptor 1 GO:0001881,GO:0005769,GO:0005802,GO:0005829,GO:0007032,GO:0030136,GO:0042147,GO:0042803,GO:0055037 receptor recycling|early endosome|trans-Golgi network|cytosol|endosome organization|clathrin-coated vesicle|retrograde transport, endosome to Golgi|protein homodimerization activity|recycling endosome PHETA2 1.94353636561208 0.980142803914724 2.90692992730943 2.96582285326082 1.56843242909583 0.614319497946813 1 0 0.0369722 0.0393137 0.0734402 GeneID:150368,Genbank:XM_005261373.3,HGNC:HGNC:27161,MIM:614240 PH domain containing endocytic trafficking adaptor 2 GO:0001881,GO:0005769,GO:0005802,GO:0005829,GO:0007032,GO:0030136,GO:0042147,GO:0042803,GO:0055037 receptor recycling|early endosome|trans-Golgi network|cytosol|endosome organization|clathrin-coated vesicle|retrograde transport, endosome to Golgi|protein homodimerization activity|recycling endosome PHEX 52.9777749123514 48.2759204194994 57.6796294052034 1.19479087926215 0.256758129626519 0.525097609801095 1 0.25934 0.284279 0.392466 0.23792 GeneID:5251,Genbank:NM_000444.5,HGNC:HGNC:8918,MIM:300550 phosphate regulating endopeptidase homolog X-linked PHF1 1432.13734933946 1288.82617850863 1575.4485201703 1.22239022332192 0.289704909856241 0.0480251483029939 0.805544588686926 19.2256 18.7253 23.5028 24.8562 GeneID:5252,Genbank:XM_011514665.1,HGNC:HGNC:8919,MIM:602881 PHD finger protein 1 GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005815,GO:0006351,GO:0006974,GO:0016569,GO:0035064,GO:0035861,GO:0045814,GO:0046872,GO:0061086,GO:0061087 chromatin binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|microtubule organizing center|transcription, DNA-templated|cellular response to DNA damage stimulus|covalent chromatin modification|methylated histone binding|site of double-strand break|negative regulation of gene expression, epigenetic|metal ion binding|negative regulation of histone H3-K27 methylation|positive regulation of histone H3-K27 methylation PHF10 716.544439172544 726.473493442692 706.615384902395 0.972665061121239 -0.0399849988714579 0.824647659568376 1 11.6312 10.7617 12.5111 10.6111 GeneID:55274,Genbank:NM_133325.2,HGNC:HGNC:18250,MIM:613069 PHD finger protein 10 GO:0005634,GO:0006351,GO:0006355,GO:0007399,GO:0046872,GO:0071564 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|nervous system development|metal ion binding|npBAF complex hsa05225 Hepatocellular carcinoma PHF11 11.4700947449971 11.3098598645963 11.6303296253979 1.02833543161793 0.0403109324282728 1 1 1.46674 1.89824 3.34596 1.73074 GeneID:51131,Genbank:NM_001040443.2,HGNC:HGNC:17024,MIM:607796 PHD finger protein 11 GO:0005654,GO:0006351,GO:0006355,GO:0031965,GO:0046872 nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear membrane|metal ion binding PHF12 1175.2080977573 1103.49599567705 1246.92019983756 1.12997256421625 0.176287744366416 0.242716641114979 1 4.36267 4.66251 5.31908 5.34629 GeneID:57649,Genbank:XM_017024904.1,HGNC:HGNC:20816 PHD finger protein 12 GO:0000122,GO:0000977,GO:0001106,GO:0001222,GO:0003682,GO:0005634,GO:0005654,GO:0006351,GO:0016580,GO:0017053,GO:0035091,GO:0042393,GO:0045892,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription corepressor activity|transcription corepressor binding|chromatin binding|nucleus|nucleoplasm|transcription, DNA-templated|Sin3 complex|transcriptional repressor complex|phosphatidylinositol binding|histone binding|negative regulation of transcription, DNA-templated|metal ion binding PHF13 939.953368525046 970.718105713634 909.188631336459 0.936614477452297 -0.0944727566291486 0.529514887980416 1 12.0583 12.7072 12.2481 11.1445 GeneID:148479,Genbank:NM_153812.2,HGNC:HGNC:22983 PHD finger protein 13 GO:0000278,GO:0003682,GO:0005634,GO:0005654,GO:0007059,GO:0007076,GO:0016569,GO:0035064,GO:0046872,GO:0051301 mitotic cell cycle|chromatin binding|nucleus|nucleoplasm|chromosome segregation|mitotic chromosome condensation|covalent chromatin modification|methylated histone binding|metal ion binding|cell division PHF14 371.75317562925 377.578183219502 365.928168038998 0.969145422860061 -0.0452149327581862 0.833549249721921 1 0.845232 0.818879 0.921165 0.703925 GeneID:9678,Genbank:NM_014660.3,HGNC:HGNC:22203 PHD finger protein 14 GO:0000122,GO:0005634,GO:0046872,GO:0048286,GO:2000584,GO:2000791 negative regulation of transcription from RNA polymerase II promoter|nucleus|metal ion binding|lung alveolus development|negative regulation of platelet-derived growth factor receptor-alpha signaling pathway|negative regulation of mesenchymal cell proliferation involved in lung development PHF19 4131.32589263336 3995.48196709939 4267.16981816732 1.06799876793466 0.0949099827037673 0.49578697790509 1 17.3436 19.3055 20.7169 20.0344 GeneID:26147,Genbank:NM_001286840.1,HGNC:HGNC:24566,MIM:609740 PHD finger protein 19 GO:0005654,GO:0006351,GO:0006355,GO:0016569,GO:0035064,GO:0045814,GO:0046872,GO:0061087 nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|covalent chromatin modification|methylated histone binding|negative regulation of gene expression, epigenetic|metal ion binding|positive regulation of histone H3-K27 methylation PHF2 1092.66898914105 1044.99621940134 1140.34175888076 1.09124008078617 0.125968540025948 0.414722785002718 1 6.90766 7.21744 8.00764 7.4295 GeneID:5253,Genbank:NM_005392.3,HGNC:HGNC:8920,MIM:604351 PHD finger protein 2 GO:0000776,GO:0000777,GO:0001889,GO:0005506,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0006482,GO:0008270,GO:0032452,GO:0032454,GO:0035064,GO:0051213,GO:0061188 kinetochore|condensed chromosome kinetochore|liver development|iron ion binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|protein demethylation|zinc ion binding|histone demethylase activity|histone demethylase activity (H3-K9 specific)|methylated histone binding|dioxygenase activity|negative regulation of chromatin silencing at rDNA PHF20 1001.71136526932 1108.32804911086 895.094681427776 0.807608074293391 -0.308272760388354 0.0451556875915309 0.791262026768008 5.31012 5.10239 4.30335 4.20876 GeneID:51230,Genbank:NM_016436.4,HGNC:HGNC:16098,MIM:610335 PHD finger protein 20 GO:0000123,GO:0003677,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0031965,GO:0043981,GO:0043982,GO:0043984,GO:0046872,GO:0071339,GO:1901796 histone acetyltransferase complex|DNA binding|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear membrane|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|metal ion binding|MLL1 complex|regulation of signal transduction by p53 class mediator PHF20L1 414.265040861787 432.541598477026 395.988483246548 0.915492254712192 -0.127380414365108 0.612710636607755 1 1.23534 1.14137 1.26831 0.909003 GeneID:51105,Genbank:NM_016018.4,HGNC:HGNC:24280 PHD finger protein 20 like 1 GO:0005634,GO:0006355,GO:0046872 nucleus|regulation of transcription, DNA-templated|metal ion binding PHF21A 626.304973503637 604.140990399547 648.468956607726 1.07337354510387 0.10215223628512 0.537506025105457 1 2.05017 2.02411 2.47714 2.14923 GeneID:51317,Genbank:NM_001352030.1,HGNC:HGNC:24156,MIM:608325 PHD finger protein 21A GO:0000118,GO:0000122,GO:0000977,GO:0003682,GO:0003712,GO:0004407,GO:0005654,GO:0006351,GO:0006355,GO:0007596,GO:0042393,GO:0046872,GO:1990391 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|chromatin binding|transcription cofactor activity|histone deacetylase activity|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|blood coagulation|histone binding|metal ion binding|DNA repair complex PHF21B 15.7929174522382 18.0169720128366 13.5688628916398 0.753115611323164 -0.409056743828441 0.59990988148906 1 0.134625 0.091961 0.0978682 0.108401 GeneID:112885,Genbank:NM_001135862.2,HGNC:HGNC:25161,MIM:616727 PHD finger protein 21B GO:0000977,GO:0003682,GO:0003712,GO:0005634,GO:0006355,GO:0042393,GO:0046872 RNA polymerase II regulatory region sequence-specific DNA binding|chromatin binding|transcription cofactor activity|nucleus|regulation of transcription, DNA-templated|histone binding|metal ion binding PHF23 1888.88590410125 1946.99069298307 1830.78111521942 0.940313234068111 -0.0887866721817559 0.563560456939584 1 23.6088 25.7312 22.3203 25.3634 GeneID:79142,Genbank:NM_001284517.1,HGNC:HGNC:28428,MIM:612910 PHD finger protein 23 GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0006914,GO:0007076,GO:0031398,GO:0046872,GO:1901097,GO:1902902 chromatin binding|nucleus|nucleoplasm|cytoplasm|autophagy|mitotic chromosome condensation|positive regulation of protein ubiquitination|metal ion binding|negative regulation of autophagosome maturation|negative regulation of autophagosome assembly PHF24 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00578001 0 GeneID:23349,Genbank:XM_011517827.1,HGNC:HGNC:29180 PHD finger protein 24 GO:0005509,GO:0007214,GO:0008277,GO:0032228,GO:0050966 calcium ion binding|gamma-aminobutyric acid signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|regulation of synaptic transmission, GABAergic|detection of mechanical stimulus involved in sensory perception of pain PHF3 236.543493132651 218.115923487184 254.971062778119 1.16897042041545 0.225238424429153 0.550742418668988 1 0.774337 0.72026 1.12721 0.655548 GeneID:23469,Genbank:NM_001290259.1,HGNC:HGNC:8921,MIM:607789 PHD finger protein 3 GO:0006351,GO:0007275,GO:0046872 transcription, DNA-templated|multicellular organism development|metal ion binding PHF5A 941.151754474724 869.977153321082 1012.32635562837 1.16362406962513 0.21862504408237 0.182056026754224 1 32.7844 37.4463 39.2104 43.3271 GeneID:84844,Genbank:NM_032758.3,HGNC:HGNC:18000,MIM:617846 PHD finger protein 5A GO:0000398,GO:0003677,GO:0003700,GO:0003723,GO:0005686,GO:0005689,GO:0006351,GO:0016363,GO:0016607,GO:0045893,GO:0046872,GO:0071011,GO:0071013 mRNA splicing, via spliceosome|DNA binding|DNA binding transcription factor activity|RNA binding|U2 snRNP|U12-type spliceosomal complex|transcription, DNA-templated|nuclear matrix|nuclear speck|positive regulation of transcription, DNA-templated|metal ion binding|precatalytic spliceosome|catalytic step 2 spliceosome hsa03040 Spliceosome PHF6 1313.96041111316 1357.05567123516 1270.86515099117 0.936487115399223 -0.0946689495140969 0.776934480438992 1 12.2724 9.83331 12.1716 8.73833 GeneID:84295,Genbank:NM_032458.2,HGNC:HGNC:18145,MIM:300414 PHD finger protein 6 GO:0000122,GO:0000777,GO:0001227,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0015631,GO:0019899,GO:0042393,GO:0042826,GO:0043021,GO:0043565,GO:0046872,GO:0051219,GO:0097110 negative regulation of transcription from RNA polymerase II promoter|condensed chromosome kinetochore|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|RNA binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|tubulin binding|enzyme binding|histone binding|histone deacetylase binding|ribonucleoprotein complex binding|sequence-specific DNA binding|metal ion binding|phosphoprotein binding|scaffold protein binding PHF7 169.537854174799 136.026093333481 203.049615016117 1.49272547670924 0.577948867544434 0.0179009252916656 0.546850871863472 1.13846 1.26637 1.97678 1.97613 GeneID:51533,Genbank:NM_001321127.1,HGNC:HGNC:18458 PHD finger protein 7 GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0016607,GO:0046872 nucleus|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|nuclear speck|metal ion binding PHF8 508.035753056747 507.656793145449 508.414712968044 1.00149297681589 0.00215230397796322 1 1 2.13574 2.13055 2.38505 1.91875 GeneID:23133,Genbank:XM_005261996.1,HGNC:HGNC:20672,MIM:300560 PHD finger protein 8 GO:0000082,GO:0003682,GO:0005506,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0007420,GO:0008270,GO:0016706,GO:0031965,GO:0032452,GO:0032454,GO:0033169,GO:0035064,GO:0035574,GO:0035575,GO:0045893,GO:0045943,GO:0051864,GO:0061188,GO:0070544,GO:0071557,GO:0071558 G1/S transition of mitotic cell cycle|chromatin binding|iron ion binding|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|brain development|zinc ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|nuclear membrane|histone demethylase activity|histone demethylase activity (H3-K9 specific)|histone H3-K9 demethylation|methylated histone binding|histone H4-K20 demethylation|histone demethylase activity (H4-K20 specific)|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase I promoter|histone demethylase activity (H3-K36 specific)|negative regulation of chromatin silencing at rDNA|histone H3-K36 demethylation|histone H3-K27 demethylation|histone demethylase activity (H3-K27 specific) PHGDH 14653.9174538564 13856.2366524912 15451.5982552217 1.11513671733109 0.157220597431706 0.569023808275346 1 50.6653 56.9819 52.3721 67.9426 GeneID:26227,Genbank:NM_006623.3,HGNC:HGNC:8923,MIM:606879 phosphoglycerate dehydrogenase GO:0004617,GO:0005829,GO:0006564,GO:0007420,GO:0009055,GO:0030060,GO:0051287,GO:0070062 phosphoglycerate dehydrogenase activity|cytosol|L-serine biosynthetic process|brain development|electron transfer activity|L-malate dehydrogenase activity|NAD binding|extracellular exosome hsa00260 Glycine, serine and threonine metabolism PHIP 199.516081102287 190.095609681353 208.936552523221 1.09911298253258 0.136339694714328 0.78720312042572 1 0.59094 0.452532 0.798161 0.376422 GeneID:55023,Genbank:NM_017934.6,HGNC:HGNC:15673,MIM:612870 pleckstrin homology domain interacting protein GO:0001932,GO:0005158,GO:0005634,GO:0007010,GO:0008284,GO:0008286,GO:0008360,GO:0022604,GO:0043066,GO:0043568,GO:0045840,GO:0045893,GO:0045944,GO:0070062,GO:0070577,GO:2001237 regulation of protein phosphorylation|insulin receptor binding|nucleus|cytoskeleton organization|positive regulation of cell proliferation|insulin receptor signaling pathway|regulation of cell shape|regulation of cell morphogenesis|negative regulation of apoptotic process|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitotic nuclear division|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|extracellular exosome|lysine-acetylated histone binding|negative regulation of extrinsic apoptotic signaling pathway PHKA1 500.168503660578 497.777912866293 502.559094454862 1.00960504969181 0.0137910313078222 0.926459280607067 1 2.71955 2.42529 2.69976 2.55632 GeneID:5255,Genbank:NM_001172436.1,HGNC:HGNC:8925,MIM:311870 phosphorylase kinase regulatory subunit alpha 1 GO:0004689,GO:0005516,GO:0005829,GO:0005886,GO:0005964,GO:0005977,GO:0005980,GO:0006091 phosphorylase kinase activity|calmodulin binding|cytosol|plasma membrane|phosphorylase kinase complex|glycogen metabolic process|glycogen catabolic process|generation of precursor metabolites and energy hsa04020,hsa04910,hsa04922 Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKA2 466.338557351289 441.757919565701 490.919195136877 1.11128555571682 0.152229578997193 0.402547173394189 1 2.45462 2.69097 2.91586 3.04667 GeneID:5256,Genbank:NM_000292.2,HGNC:HGNC:8926,MIM:300798 phosphorylase kinase regulatory subunit alpha 2 GO:0004689,GO:0005516,GO:0005829,GO:0005886,GO:0005964,GO:0005975,GO:0005980,GO:0006091,GO:0006464 phosphorylase kinase activity|calmodulin binding|cytosol|plasma membrane|phosphorylase kinase complex|carbohydrate metabolic process|glycogen catabolic process|generation of precursor metabolites and energy|cellular protein modification process hsa04020,hsa04910,hsa04922 Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKB 1210.74221747607 1207.38706488859 1214.09737006356 1.00555770835229 0.00799587942011487 0.938973021106473 1 6.58402 5.95842 7.31058 5.67623 GeneID:5257,Genbank:XM_005255984.4,HGNC:HGNC:8927,MIM:172490 phosphorylase kinase regulatory subunit beta GO:0004689,GO:0005516,GO:0005829,GO:0005886,GO:0005964,GO:0005977,GO:0005980,GO:0006091 phosphorylase kinase activity|calmodulin binding|cytosol|plasma membrane|phosphorylase kinase complex|glycogen metabolic process|glycogen catabolic process|generation of precursor metabolites and energy hsa04020,hsa04910,hsa04922 Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKG1 114.024839772921 110.312057713382 117.737621832459 1.06731416558624 0.0939848982054798 0.825040857629134 1 0.905547 0.860438 0.666287 1.19358 GeneID:5260,Genbank:XM_017012324.2,HGNC:HGNC:8930,MIM:172470 phosphorylase kinase catalytic subunit gamma 1 GO:0004689,GO:0005516,GO:0005524,GO:0005829,GO:0005964,GO:0005975,GO:0005977,GO:0005978,GO:0005980,GO:0018105,GO:0018107,GO:0019899,GO:0035556,GO:0050321 phosphorylase kinase activity|calmodulin binding|ATP binding|cytosol|phosphorylase kinase complex|carbohydrate metabolic process|glycogen metabolic process|glycogen biosynthetic process|glycogen catabolic process|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|enzyme binding|intracellular signal transduction|tau-protein kinase activity hsa04020,hsa04910,hsa04922 Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHKG2 597.765794732132 624.638762388349 570.892827075915 0.913956772219942 -0.129802163716419 0.478834684909652 1 3.9703 5.0734 4.05419 4.05342 GeneID:5261,Genbank:NM_000294.2,HGNC:HGNC:8931,MIM:172471 phosphorylase kinase catalytic subunit gamma 2 GO:0004674,GO:0004689,GO:0005516,GO:0005524,GO:0005829,GO:0005964,GO:0005977,GO:0005978,GO:0005980,GO:0006091,GO:0006468,GO:0018105,GO:0018107,GO:0019899,GO:0035556,GO:0045819,GO:0050321 protein serine/threonine kinase activity|phosphorylase kinase activity|calmodulin binding|ATP binding|cytosol|phosphorylase kinase complex|glycogen metabolic process|glycogen biosynthetic process|glycogen catabolic process|generation of precursor metabolites and energy|protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|enzyme binding|intracellular signal transduction|positive regulation of glycogen catabolic process|tau-protein kinase activity hsa04020,hsa04910,hsa04922 Calcium signaling pathway|Insulin signaling pathway|Glucagon signaling pathway PHLDA1 3979.2692052762 3650.56978667249 4307.9686238799 1.18008115872964 0.23888608269764 0.0744832320568824 0.93930979891577 29.3588 30.058 37.2277 33.3889 GeneID:22822,Genbank:NM_007350.3,HGNC:HGNC:8933,MIM:605335 pleckstrin homology like domain family A member 1 GO:0000086,GO:0005634,GO:0005730,GO:0005829,GO:0006915,GO:0031410,GO:0045210 G2/M transition of mitotic cell cycle|nucleus|nucleolus|cytosol|apoptotic process|cytoplasmic vesicle|FasL biosynthetic process PHLDA2 720.489161567793 866.238878549055 574.73944458653 0.663488396583186 -0.591856859643475 0.000230201535677035 0.0396441698430472 71.1329 73.6405 46.3784 50.8782 GeneID:7262,Genbank:NM_003311.3,HGNC:HGNC:12385,MIM:602131 pleckstrin homology like domain family A member 2 GO:0001890,GO:0005737,GO:0006915,GO:0009887,GO:0010468,GO:0016020,GO:0030334,GO:0060721,GO:0070873,GO:1903547 placenta development|cytoplasm|apoptotic process|animal organ morphogenesis|regulation of gene expression|membrane|regulation of cell migration|regulation of spongiotrophoblast cell proliferation|regulation of glycogen metabolic process|regulation of growth hormone activity PHLDA3 581.443204753162 559.075055730541 603.811353775784 1.08001841181554 0.111055907211484 0.523382999019891 1 8.78627 9.4211 9.59533 10.281 GeneID:23612,Genbank:NM_012396.4,HGNC:HGNC:8934,MIM:607054 pleckstrin homology like domain family A member 3 GO:0005546,GO:0005547,GO:0005737,GO:0005886,GO:0009653,GO:0010314,GO:0032266,GO:0042771,GO:0043065,GO:0043325,GO:0051898,GO:0070062,GO:0080025 phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|cytoplasm|plasma membrane|anatomical structure morphogenesis|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-3-phosphate binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of apoptotic process|phosphatidylinositol-3,4-bisphosphate binding|negative regulation of protein kinase B signaling|extracellular exosome|phosphatidylinositol-3,5-bisphosphate binding PHLDB1 2550.30475813653 2460.44987371114 2640.15964256192 1.07303939445014 0.10170304266905 0.465660350301409 1 8.10572 7.90353 8.37504 8.64947 GeneID:23187,Genbank:XM_011542709.2,HGNC:HGNC:23697,MIM:612834 pleckstrin homology like domain family B member 1 GO:0010470,GO:0010717,GO:0045180,GO:0070507,GO:1904261 regulation of gastrulation|regulation of epithelial to mesenchymal transition|basal cortex|regulation of microtubule cytoskeleton organization|positive regulation of basement membrane assembly involved in embryonic body morphogenesis PHLDB2 146.738967234122 188.299020207794 105.17891426045 0.558573879696144 -0.840179983700427 0.00110399336325876 0.109145417937978 0.928898 0.865787 0.603741 0.42655 GeneID:90102,Genbank:NM_001134437.1,HGNC:HGNC:29573,MIM:610298 pleckstrin homology like domain family B member 2 GO:0000226,GO:0005829,GO:0005886,GO:0010470,GO:0010717,GO:0031252,GO:0045111,GO:0045180,GO:0045184,GO:0045296,GO:0051497,GO:0051895,GO:0070507,GO:1903690,GO:1904261 microtubule cytoskeleton organization|cytosol|plasma membrane|regulation of gastrulation|regulation of epithelial to mesenchymal transition|cell leading edge|intermediate filament cytoskeleton|basal cortex|establishment of protein localization|cadherin binding|negative regulation of stress fiber assembly|negative regulation of focal adhesion assembly|regulation of microtubule cytoskeleton organization|negative regulation of wound healing, spreading of epidermal cells|positive regulation of basement membrane assembly involved in embryonic body morphogenesis PHLDB3 201.856740108135 200.666475116314 203.047005099956 1.01186311755495 0.0170141388648915 0.976099740179745 1 1.40388 1.62526 1.48525 1.87381 GeneID:653583,Genbank:XM_011527236.3,HGNC:HGNC:30499 pleckstrin homology like domain family B member 3 GO:0019899 enzyme binding PHLPP1 473.354170304028 423.731138897756 522.9772017103 1.23421942288856 0.303598903540842 0.135484553746908 1 2.52819 2.70989 3.80952 2.83226 GeneID:23239,Genbank:NM_194449.3,HGNC:HGNC:20610,MIM:609396 PH domain and leucine rich repeat protein phosphatase 1 hsa04151 PI3K-Akt signaling pathway PHLPP2 800.962285358579 874.395570592097 727.529000125061 0.832036465638104 -0.265281336181577 0.185112209870952 1 3.5803 3.52199 3.54369 2.44604 GeneID:23035,Genbank:NM_015020.3,HGNC:HGNC:29149,MIM:611066 PH domain and leucine rich repeat protein phosphatase 2 hsa04151 PI3K-Akt signaling pathway PHOSPHO1 7.59183162090835 10.819788462639 4.36387477917774 0.403323484026173 -1.30999068393227 0.236413178961835 1 0.302235 0.231875 0.125491 0.0469734 GeneID:162466,Genbank:XM_017024271.1,HGNC:HGNC:16815 phosphoethanolamine/phosphocholine phosphatase GO:0001958,GO:0005578,GO:0005829,GO:0006646,GO:0006656,GO:0016462,GO:0016791,GO:0030500,GO:0035630,GO:0046872,GO:0052731,GO:0052732,GO:0065010 endochondral ossification|proteinaceous extracellular matrix|cytosol|phosphatidylethanolamine biosynthetic process|phosphatidylcholine biosynthetic process|pyrophosphatase activity|phosphatase activity|regulation of bone mineralization|bone mineralization involved in bone maturation|metal ion binding|phosphocholine phosphatase activity|phosphoethanolamine phosphatase activity|extracellular membrane-bounded organelle hsa00564 Glycerophospholipid metabolism PHOSPHO2 22.0513239838146 19.3911336693388 24.7115142982904 1.27437181959939 0.349786269767984 0.59355965139901 1 0.729648 1.07911 0.922751 1.11697 GeneID:493911,Genbank:NM_001199286.1,HGNC:HGNC:28316 phosphatase, orphan 2 GO:0016791,GO:0033883,GO:0046872 phosphatase activity|pyridoxal phosphatase activity|metal ion binding hsa00750 Vitamin B6 metabolism PHPT1 1541.61366487015 1611.61648526169 1471.61084447862 0.913127197404944 -0.131112255177769 0.626772069563602 1 10.5301 11.4561 9.06824 11.8273 GeneID:29085,Genbank:NM_001287342.1,HGNC:HGNC:30033,MIM:610167 phosphohistidine phosphatase 1 GO:0005829,GO:0006470,GO:0019855,GO:0035774,GO:0035971,GO:0044325,GO:0050860,GO:0051350,GO:0070062,GO:0101006,GO:2000147,GO:2000249,GO:2000984 cytosol|protein dephosphorylation|calcium channel inhibitor activity|positive regulation of insulin secretion involved in cellular response to glucose stimulus|peptidyl-histidine dephosphorylation|ion channel binding|negative regulation of T cell receptor signaling pathway|negative regulation of lyase activity|extracellular exosome|protein histidine phosphatase activity|positive regulation of cell motility|regulation of actin cytoskeleton reorganization|negative regulation of ATP citrate synthase activity PHRF1 1727.00222150013 1724.85712873 1729.14731427027 1.00248727008678 0.00358391698017358 0.99563087040154 1 11.0554 11.1727 11.5018 11.0388 GeneID:57661,Genbank:NM_001286581.1,HGNC:HGNC:24351,MIM:611780 PHD and ring finger domains 1 GO:0006366,GO:0006397,GO:0016020,GO:0019904,GO:0046872,GO:0070063 transcription from RNA polymerase II promoter|mRNA processing|membrane|protein domain specific binding|metal ion binding|RNA polymerase binding PHTF1 789.760127020274 715.365547331943 864.154706708605 1.20799039027193 0.272608977873108 0.0830658444683746 0.963076417285947 5.15787 5.14051 6.75908 5.91863 GeneID:10745,Genbank:NM_006608.2,HGNC:HGNC:8939,MIM:604950 putative homeodomain transcription factor 1 GO:0003677,GO:0003700,GO:0005634,GO:0005783,GO:0005801,GO:0006351 DNA binding|DNA binding transcription factor activity|nucleus|endoplasmic reticulum|cis-Golgi network|transcription, DNA-templated PHTF2 625.640269458129 661.928147208375 589.352391707883 0.890357048863122 -0.167544096644559 0.547635482740249 1 3.52231 2.60132 3.11148 2.28405 GeneID:57157,Genbank:NM_001127358.1,HGNC:HGNC:13411,MIM:616785 putative homeodomain transcription factor 2 GO:0003677,GO:0005634,GO:0005783,GO:0006351,GO:0006355 DNA binding|nucleus|endoplasmic reticulum|transcription, DNA-templated|regulation of transcription, DNA-templated PHYH 429.544031718822 357.976344142063 501.111719295581 1.39984590461295 0.485268023679961 0.00768917939945299 0.342738246075193 4.26517 4.56903 6.9632 6.35479 GeneID:5264,Genbank:NM_001323083.1,HGNC:HGNC:8940,MIM:602026 phytanoyl-CoA 2-hydroxylase GO:0001561,GO:0005739,GO:0005777,GO:0005782,GO:0006103,GO:0006720,GO:0008198,GO:0031406,GO:0031418,GO:0048037,GO:0048244,GO:0097089 fatty acid alpha-oxidation|mitochondrion|peroxisome|peroxisomal matrix|2-oxoglutarate metabolic process|isoprenoid metabolic process|ferrous iron binding|carboxylic acid binding|L-ascorbic acid binding|cofactor binding|phytanoyl-CoA dioxygenase activity|methyl-branched fatty acid metabolic process hsa04146 Peroxisome PHYHIP 57.5694168187686 51.658393958516 63.4804396790213 1.22885043096769 0.297309329353711 0.449413097049675 1 0.467304 0.458985 0.530323 0.607815 GeneID:9796,Genbank:NM_014759.3,HGNC:HGNC:16865,MIM:608511 phytanoyl-CoA 2-hydroxylase interacting protein PHYHIPL 18.3835467783147 22.7157722785625 14.0513212780668 0.618571145447138 -0.692988557436949 0.312734727760495 1 0.236436 0.208788 0.0763127 0.151975 GeneID:84457,Genbank:XM_011540276.3,HGNC:HGNC:29378 phytanoyl-CoA 2-hydroxylase interacting protein like GO:0005737,GO:0005739 cytoplasm|mitochondrion PHYKPL 472.114188540211 459.169150316994 485.059226763428 1.05638461649386 0.0791351976535937 0.695219807711281 1 1.12763 1.03736 1.11022 1.22522 GeneID:85007,Genbank:NM_153373.3,HGNC:HGNC:28249,MIM:614683 5-phosphohydroxy-L-lysine phospho-lyase GO:0005739,GO:0005759,GO:0006554,GO:0008453,GO:0016829,GO:0030170,GO:0030574,GO:0042802 mitochondrion|mitochondrial matrix|lysine catabolic process|alanine-glyoxylate transaminase activity|lyase activity|pyridoxal phosphate binding|collagen catabolic process|identical protein binding hsa00310 Lysine degradation PI15 8.88033539097408 6.61105959887042 11.1496111830777 1.68650895009066 0.754039974577296 0.474164476415587 1 0.0230136 0.0610759 0.112159 0.0556823 GeneID:51050,Genbank:NM_001324403.1,HGNC:HGNC:8946,MIM:607076 peptidase inhibitor 15 GO:0007275,GO:0030414,GO:0070062 multicellular organism development|peptidase inhibitor activity|extracellular exosome PI16 2.18694048895906 0.980142803914724 3.3937381740034 3.46249358812684 1.79181139957015 0.511793170645444 1 0 0.0299074 0.0634584 0.0148518 GeneID:221476,Genbank:NM_001199159.1,HGNC:HGNC:21245 peptidase inhibitor 16 GO:0030414,GO:0070062 peptidase inhibitor activity|extracellular exosome PI3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0993215 GeneID:5266,Genbank:NM_002638.3,HGNC:HGNC:8947,MIM:182257 peptidase inhibitor 3 GO:0001533,GO:0004866,GO:0004867,GO:0005576,GO:0005578,GO:0005829,GO:0007620,GO:0018149,GO:0019730,GO:0030280,GO:0070062,GO:0070268 cornified envelope|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|proteinaceous extracellular matrix|cytosol|copulation|peptide cross-linking|antimicrobial humoral response|structural constituent of epidermis|extracellular exosome|cornification PI4K2A 1918.56434368035 1940.78244389104 1896.34624346966 0.977103976511508 -0.0334160030970523 0.802679715047298 1 18.4732 19.4834 19.3563 18.5492 GeneID:55361,Genbank:NM_018425.3,HGNC:HGNC:30031,MIM:609763 phosphatidylinositol 4-kinase type 2 alpha GO:0000287,GO:0002561,GO:0004430,GO:0005524,GO:0005739,GO:0005765,GO:0005768,GO:0005802,GO:0005829,GO:0005887,GO:0006661,GO:0007030,GO:0007032,GO:0016020,GO:0030054,GO:0030425,GO:0030672,GO:0031224,GO:0031410,GO:0031901,GO:0035651,GO:0035838,GO:0042734,GO:0043005,GO:0043025,GO:0043204,GO:0043234,GO:0044231,GO:0045121,GO:0046854 magnesium ion binding|basophil degranulation|1-phosphatidylinositol 4-kinase activity|ATP binding|mitochondrion|lysosomal membrane|endosome|trans-Golgi network|cytosol|integral component of plasma membrane|phosphatidylinositol biosynthetic process|Golgi organization|endosome organization|membrane|cell junction|dendrite|synaptic vesicle membrane|intrinsic component of membrane|cytoplasmic vesicle|early endosome membrane|AP-3 adaptor complex binding|growing cell tip|presynaptic membrane|neuron projection|neuronal cell body|perikaryon|protein complex|host cell presynaptic membrane|membrane raft|phosphatidylinositol phosphorylation hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system PI4K2B 606.593864473581 651.425942359169 561.761786587992 0.862357100108027 -0.213642685118887 0.438948671324948 1 8.59546 7.23255 8.21348 5.75237 GeneID:55300,Genbank:NM_018323.3,HGNC:HGNC:18215,MIM:612101 phosphatidylinositol 4-kinase type 2 beta GO:0004430,GO:0005524,GO:0005768,GO:0005802,GO:0005829,GO:0005886,GO:0006661,GO:0007030,GO:0007032,GO:0016020,GO:0046854 1-phosphatidylinositol 4-kinase activity|ATP binding|endosome|trans-Golgi network|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|Golgi organization|endosome organization|membrane|phosphatidylinositol phosphorylation hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system PI4KA 2798.89604669277 2602.30879759343 2995.48329579211 1.15108679591073 0.202996621748896 0.141144899647678 1 11.527 11.1798 13.2776 12.6756 GeneID:5297,Genbank:XM_017028829.1,HGNC:HGNC:8983,MIM:600286 phosphatidylinositol 4-kinase alpha GO:0004430,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0006661,GO:0007165,GO:0016020,GO:0016301,GO:0016310,GO:0019034,GO:0030036,GO:0030660,GO:0039694,GO:0044803,GO:0045296,GO:0046786,GO:0046854,GO:0048015,GO:0070062 1-phosphatidylinositol 4-kinase activity|ATP binding|cytoplasm|cytosol|plasma membrane|focal adhesion|phosphatidylinositol biosynthetic process|signal transduction|membrane|kinase activity|phosphorylation|viral replication complex|actin cytoskeleton organization|Golgi-associated vesicle membrane|viral RNA genome replication|multi-organism membrane organization|cadherin binding|viral replication complex formation and maintenance|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|extracellular exosome hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system PI4KB 3461.03639816848 3365.31713211971 3556.75566421725 1.05688573307709 0.0798194058271897 0.563877372425343 1 22.3028 22.8421 25.476 23.1677 GeneID:5298,Genbank:NM_001198775.2,HGNC:HGNC:8984,MIM:602758 phosphatidylinositol 4-kinase beta GO:0000139,GO:0004430,GO:0005524,GO:0005737,GO:0005741,GO:0005768,GO:0005829,GO:0006661,GO:0006898,GO:0007165,GO:0016020,GO:0030867,GO:0048015,GO:0048471,GO:0071889 Golgi membrane|1-phosphatidylinositol 4-kinase activity|ATP binding|cytoplasm|mitochondrial outer membrane|endosome|cytosol|phosphatidylinositol biosynthetic process|receptor-mediated endocytosis|signal transduction|membrane|rough endoplasmic reticulum membrane|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|14-3-3 protein binding hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system PIANP 212.897295954159 211.582316128322 214.212275779995 1.01242995964785 0.0178221051687516 0.96769064551331 1 1.3272 1.53509 1.59999 1.42203 GeneID:196500,Genbank:XM_011520926.3,HGNC:HGNC:25338,MIM:616065 PILR alpha associated neural protein GO:0005886,GO:0005912,GO:0016021,GO:0016323,GO:0050776 plasma membrane|adherens junction|integral component of membrane|basolateral plasma membrane|regulation of immune response PIAS1 284.721665234124 310.141451848981 259.301878619267 0.83607617451127 -0.25829370331902 0.304700199185424 1 1.70652 1.4111 1.43162 1.11722 GeneID:8554,Genbank:NM_016166.2,HGNC:HGNC:2752,MIM:603566 protein inhibitor of activated STAT 1 GO:0000082,GO:0000122,GO:0003677,GO:0003713,GO:0003714,GO:0005634,GO:0005654,GO:0006351,GO:0007259,GO:0007283,GO:0008022,GO:0008270,GO:0008542,GO:0016605,GO:0016607,GO:0016874,GO:0016925,GO:0019789,GO:0019899,GO:0019904,GO:0030521,GO:0031625,GO:0032436,GO:0033235,GO:0042127,GO:0043066,GO:0045444,GO:0045893,GO:0050681,GO:0051152,GO:0060334,GO:0061665,GO:0065004 G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|DNA binding|transcription coactivator activity|transcription corepressor activity|nucleus|nucleoplasm|transcription, DNA-templated|JAK-STAT cascade|spermatogenesis|protein C-terminus binding|zinc ion binding|visual learning|PML body|nuclear speck|ligase activity|protein sumoylation|SUMO transferase activity|enzyme binding|protein domain specific binding|androgen receptor signaling pathway|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein sumoylation|regulation of cell proliferation|negative regulation of apoptotic process|fat cell differentiation|positive regulation of transcription, DNA-templated|androgen receptor binding|positive regulation of smooth muscle cell differentiation|regulation of interferon-gamma-mediated signaling pathway|SUMO ligase activity|protein-DNA complex assembly hsa04120,hsa04630,hsa05160 Ubiquitin mediated proteolysis|Jak-STAT signaling pathway|Hepatitis C PIAS2 136.478389082008 148.392531241147 124.564246922869 0.839423964811575 -0.252528443408496 0.352817903419758 1 0.248365 0.214909 0.21204 0.146528 GeneID:9063,Genbank:NM_004671.4,HGNC:HGNC:17311,MIM:603567 protein inhibitor of activated STAT 2 GO:0003677,GO:0003713,GO:0005634,GO:0005654,GO:0006351,GO:0008134,GO:0008270,GO:0016605,GO:0016607,GO:0016874,GO:0016925,GO:0019789,GO:0030521,GO:0031625,GO:0043433,GO:0045667,GO:0045893,GO:0045944,GO:0050681,GO:0060766,GO:0061665 DNA binding|transcription coactivator activity|nucleus|nucleoplasm|transcription, DNA-templated|transcription factor binding|zinc ion binding|PML body|nuclear speck|ligase activity|protein sumoylation|SUMO transferase activity|androgen receptor signaling pathway|ubiquitin protein ligase binding|negative regulation of DNA binding transcription factor activity|regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|androgen receptor binding|negative regulation of androgen receptor signaling pathway|SUMO ligase activity hsa04120,hsa04630 Ubiquitin mediated proteolysis|Jak-STAT signaling pathway PIAS3 723.581607900798 707.62147445085 739.541741350745 1.04510923997137 0.0636537477876006 0.703920023219272 1 8.41061 8.62315 9.29132 9.0369 GeneID:10401,Genbank:NM_006099.3,HGNC:HGNC:16861,MIM:605987 protein inhibitor of activated STAT 3 hsa04120,hsa04630 Ubiquitin mediated proteolysis|Jak-STAT signaling pathway PIAS4 1045.32059946356 1115.70077145215 974.940427474965 0.873836831900746 -0.194564178758836 0.436694783302192 1 11.4597 13.0323 9.39542 12.4843 GeneID:51588,Genbank:NM_015897.3,HGNC:HGNC:17002,MIM:605989 protein inhibitor of activated STAT 4 GO:0000122,GO:0003677,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0006303,GO:0006351,GO:0008022,GO:0008270,GO:0010804,GO:0016055,GO:0016363,GO:0016605,GO:0016925,GO:0019789,GO:0031625,GO:0032088,GO:0033235,GO:0042359,GO:0045892,GO:0061665,GO:1902174,GO:1902231,GO:1990234 negative regulation of transcription from RNA polymerase II promoter|DNA binding|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|double-strand break repair via nonhomologous end joining|transcription, DNA-templated|protein C-terminus binding|zinc ion binding|negative regulation of tumor necrosis factor-mediated signaling pathway|Wnt signaling pathway|nuclear matrix|PML body|protein sumoylation|SUMO transferase activity|ubiquitin protein ligase binding|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein sumoylation|vitamin D metabolic process|negative regulation of transcription, DNA-templated|SUMO ligase activity|positive regulation of keratinocyte apoptotic process|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage|transferase complex hsa04064,hsa04120,hsa04630,hsa05418 NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Jak-STAT signaling pathway|Fluid shear stress and atherosclerosis PIBF1 42.4475454111054 50.9664088027109 33.9286820195 0.66570674325587 -0.587041312822462 0.186231070245618 1 0.358949 0.235206 0.241504 0.233638 GeneID:10464,Genbank:NM_001349655.1,HGNC:HGNC:23352,MIM:607532 progesterone immunomodulatory binding factor 1 GO:0002376,GO:0005136,GO:0005615,GO:0005634,GO:0005813,GO:0005815,GO:0007080,GO:0031393,GO:0032695,GO:0032733,GO:0032815,GO:0034451,GO:0042531,GO:0042532,GO:0042976,GO:0071539,GO:0090307,GO:1905515 immune system process|interleukin-4 receptor binding|extracellular space|nucleus|centrosome|microtubule organizing center|mitotic metaphase plate congression|negative regulation of prostaglandin biosynthetic process|negative regulation of interleukin-12 production|positive regulation of interleukin-10 production|negative regulation of natural killer cell activation|centriolar satellite|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of tyrosine phosphorylation of STAT protein|activation of Janus kinase activity|protein localization to centrosome|mitotic spindle assembly|non-motile cilium assembly PICALM 2757.72082206222 2944.75165934774 2570.6899847767 0.872973439582374 -0.195990334693258 0.23732269858774 1 24.8571 22.497 24.1689 18.161 GeneID:8301,Genbank:NM_001206947.1,HGNC:HGNC:15514,MIM:603025 phosphatidylinositol binding clathrin assembly protein GO:0005545,GO:0005622,GO:0005634,GO:0005769,GO:0005794,GO:0005905,GO:0006898,GO:0007409,GO:0007611,GO:0008283,GO:0009986,GO:0010629,GO:0016050,GO:0016188,GO:0016197,GO:0017137,GO:0030097,GO:0030100,GO:0030122,GO:0030136,GO:0030276,GO:0031623,GO:0031982,GO:0032050,GO:0032880,GO:0035459,GO:0035615,GO:0043025,GO:0043231,GO:0043547,GO:0045056,GO:0045296,GO:0045893,GO:0048261,GO:0048268,GO:0048813,GO:0050750,GO:0055072,GO:0070381,GO:0072583,GO:0090647,GO:0097418,GO:0097494,GO:0097753,GO:0098711,GO:1900223,GO:1901216,GO:1902004,GO:1902959,GO:1902961,GO:1902963,GO:1903077,GO:2000009 1-phosphatidylinositol binding|intracellular|nucleus|early endosome|Golgi apparatus|clathrin-coated pit|receptor-mediated endocytosis|axonogenesis|learning or memory|cell proliferation|cell surface|negative regulation of gene expression|vesicle organization|synaptic vesicle maturation|endosomal transport|Rab GTPase binding|hemopoiesis|regulation of endocytosis|AP-2 adaptor complex|clathrin-coated vesicle|clathrin binding|receptor internalization|vesicle|clathrin heavy chain binding|regulation of protein localization|cargo loading into vesicle|clathrin adaptor activity|neuronal cell body|intracellular membrane-bounded organelle|positive regulation of GTPase activity|transcytosis|cadherin binding|positive regulation of transcription, DNA-templated|negative regulation of receptor-mediated endocytosis|clathrin coat assembly|dendrite morphogenesis|low-density lipoprotein particle receptor binding|iron ion homeostasis|endosome to plasma membrane transport vesicle|clathrin-dependent endocytosis|modulation of age-related behavioral decline|neurofibrillary tangle|regulation of vesicle size|membrane bending|iron ion import across plasma membrane|positive regulation of amyloid-beta clearance|positive regulation of neuron death|positive regulation of amyloid-beta formation|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of protein localization to plasma membrane|negative regulation of protein localization to cell surface PICK1 585.853524957686 602.796254708369 568.910795207003 0.943786214269431 -0.0834679964687421 0.613916656815014 1 7.03601 6.77371 6.14233 7.27394 GeneID:9463,Genbank:XM_017029091.1,HGNC:HGNC:9394,MIM:605926 protein interacting with PRKCA 1 GO:0001664,GO:0002092,GO:0005080,GO:0005102,GO:0005737,GO:0005739,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0006890,GO:0007205,GO:0008022,GO:0014069,GO:0015844,GO:0016235,GO:0019899,GO:0019904,GO:0021782,GO:0030054,GO:0030666,GO:0034315,GO:0034316,GO:0036294,GO:0042149,GO:0042734,GO:0042802,GO:0043005,GO:0043045,GO:0043046,GO:0043113,GO:0045161,GO:0045202,GO:0045211,GO:0046872,GO:0048471,GO:0051015,GO:0060292,GO:0071933,GO:0097061,GO:0097062 G-protein coupled receptor binding|positive regulation of receptor internalization|protein kinase C binding|receptor binding|cytoplasm|mitochondrion|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|retrograde vesicle-mediated transport, Golgi to ER|protein kinase C-activating G-protein coupled receptor signaling pathway|protein C-terminus binding|postsynaptic density|monoamine transport|aggresome|enzyme binding|protein domain specific binding|glial cell development|cell junction|endocytic vesicle membrane|regulation of Arp2/3 complex-mediated actin nucleation|negative regulation of Arp2/3 complex-mediated actin nucleation|cellular response to decreased oxygen levels|cellular response to glucose starvation|presynaptic membrane|identical protein binding|neuron projection|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|receptor clustering|neuronal ion channel clustering|synapse|postsynaptic membrane|metal ion binding|perinuclear region of cytoplasm|actin filament binding|long term synaptic depression|Arp2/3 complex binding|dendritic spine organization|dendritic spine maintenance PID1 421.958928984789 397.546649185915 446.371208783663 1.12281466765656 0.167119815433653 0.371482726734259 1 1.68583 1.99361 2.30844 1.86815 GeneID:55022,Genbank:NM_001330157.1,HGNC:HGNC:26084,MIM:612930 phosphotyrosine interaction domain containing 1 GO:0001933,GO:0005737,GO:0010628,GO:0044320,GO:0045944,GO:0046325,GO:0046627,GO:0051881,GO:0070346,GO:0070584,GO:0071345,GO:0071354,GO:0071356,GO:0071398,GO:0090298,GO:1903077,GO:2000045,GO:2000377,GO:2000379,GO:2001170,GO:2001171,GO:2001274 negative regulation of protein phosphorylation|cytoplasm|positive regulation of gene expression|cellular response to leptin stimulus|positive regulation of transcription from RNA polymerase II promoter|negative regulation of glucose import|negative regulation of insulin receptor signaling pathway|regulation of mitochondrial membrane potential|positive regulation of fat cell proliferation|mitochondrion morphogenesis|cellular response to cytokine stimulus|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to fatty acid|negative regulation of mitochondrial DNA replication|negative regulation of protein localization to plasma membrane|regulation of G1/S transition of mitotic cell cycle|regulation of reactive oxygen species metabolic process|positive regulation of reactive oxygen species metabolic process|negative regulation of ATP biosynthetic process|positive regulation of ATP biosynthetic process|negative regulation of glucose import in response to insulin stimulus PIDD1 332.476615207781 322.326610313869 342.626620101693 1.06297962730429 0.0881139469454827 0.660843583377535 1 2.48614 2.50331 2.9007 2.72533 GeneID:55367,Genbank:XM_005253007.4,HGNC:HGNC:16491,MIM:605247 p53-induced death domain protein 1 GO:0005123,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006915,GO:0006919,GO:0006974,GO:0006977,GO:0007165,GO:0042981,GO:0043065,GO:0043066,GO:0051092,GO:1902043 death receptor binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|signal transduction|regulation of apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors hsa04064,hsa04115,hsa04210 NF-kappa B signaling pathway|p53 signaling pathway|Apoptosis PIEZO1 4942.51961491296 4913.57236170656 4971.46686811935 1.0117825692085 0.016899290004937 0.925776165442172 1 25.806 26.7888 28.7259 25.8562 GeneID:9780,Genbank:NM_001142864.3,HGNC:HGNC:28993,MIM:611184 piezo type mechanosensitive ion channel component 1 GO:0005261,GO:0005783,GO:0005789,GO:0005886,GO:0006812,GO:0008381,GO:0016021,GO:0031258,GO:0033116,GO:0033625,GO:0033634,GO:0042391,GO:0050982,GO:0071260 cation channel activity|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|cation transport|mechanosensitive ion channel activity|integral component of membrane|lamellipodium membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|positive regulation of integrin activation|positive regulation of cell-cell adhesion mediated by integrin|regulation of membrane potential|detection of mechanical stimulus|cellular response to mechanical stimulus PIEZO2 5.40368163414949 4.50669516698614 6.30066810131283 1.39806839998153 0.48343494576354 0.789630260926231 1 0.00737069 0.0205363 0.0210614 0.0195842 GeneID:63895,Genbank:XM_017025918.2,HGNC:HGNC:26270,MIM:613629 piezo type mechanosensitive ion channel component 2 GO:0005261,GO:0005886,GO:0006812,GO:0008381,GO:0009612,GO:0016021,GO:0042391,GO:0050974,GO:0050982,GO:0071260 cation channel activity|plasma membrane|cation transport|mechanosensitive ion channel activity|response to mechanical stimulus|integral component of membrane|regulation of membrane potential|detection of mechanical stimulus involved in sensory perception|detection of mechanical stimulus|cellular response to mechanical stimulus PIF1 330.774020134415 335.385033377339 326.163006891491 0.972503166307149 -0.0402251476078794 0.850938859991402 1 4.29509 4.18797 4.21951 4.03417 GeneID:80119,Genbank:NM_001286497.1,HGNC:HGNC:26220,MIM:610953 PIF1 5'-to-3' DNA helicase GO:0000002,GO:0000287,GO:0000723,GO:0000784,GO:0005524,GO:0005657,GO:0005739,GO:0006260,GO:0006281,GO:0006310,GO:0010521,GO:0017116,GO:0032204,GO:0032211,GO:0033682,GO:0042162,GO:0043141,GO:0044806,GO:0051974 mitochondrial genome maintenance|magnesium ion binding|telomere maintenance|nuclear chromosome, telomeric region|ATP binding|replication fork|mitochondrion|DNA replication|DNA repair|DNA recombination|telomerase inhibitor activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity|regulation of telomere maintenance|negative regulation of telomere maintenance via telomerase|ATP-dependent 5'-3' DNA/RNA helicase activity|telomeric DNA binding|ATP-dependent 5'-3' DNA helicase activity|G-quadruplex DNA unwinding|negative regulation of telomerase activity PIFO 1.78435278316639 3.084507235799 0.484198330533773 0.156977531099339 -2.67137002042877 0.394678129197313 1 0.0512084 0.048493 0 0.0152553 GeneID:128344,Genbank:XM_005270472.1,HGNC:HGNC:27009,MIM:614234 primary cilia formation GO:0005634,GO:0005802,GO:0017137,GO:0019894,GO:0019901,GO:0030030,GO:0031344,GO:0031410,GO:0033674,GO:0036064,GO:0043015,GO:0048487 nucleus|trans-Golgi network|Rab GTPase binding|kinesin binding|protein kinase binding|cell projection organization|regulation of cell projection organization|cytoplasmic vesicle|positive regulation of kinase activity|ciliary basal body|gamma-tubulin binding|beta-tubulin binding PIGA 100.443678062556 112.68496248316 88.2023936419524 0.782734374652107 -0.353405291059564 0.440392500916044 1 1.12283 0.667032 0.678402 0.61529 GeneID:5277,Genbank:NM_020473.3,HGNC:HGNC:8957,MIM:311770 phosphatidylinositol glycan anchor biosynthesis class A hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGB 455.553853323805 446.850738684014 464.256967963597 1.03895311738959 0.0551305543041223 0.776096464398123 1 6.80307 8.19522 7.94917 7.78686 GeneID:9488,Genbank:NM_004855.4,HGNC:HGNC:8959,MIM:604122 phosphatidylinositol glycan anchor biosynthesis class B GO:0000030,GO:0004376,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0097502 mannosyltransferase activity|glycolipid mannosyltransferase activity|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|mannosylation hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGBOS1 234.81799689677 235.066508801844 234.569484991695 0.997885603471621 -0.00305365884766132 1 1 5.63079 5.87613 6.26375 5.12641 GeneID:101928527,Genbank:NM_001308423.1,HGNC:HGNC:50696 PIGB opposite strand 1 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding PIGC 496.138561886789 507.196147708816 485.080976064763 0.956397201075057 -0.0643181869217236 0.701477922993168 1 13.6519 16.3031 13.0222 15.2574 GeneID:5279,Genbank:NM_153747.1,HGNC:HGNC:8960,MIM:601730 phosphatidylinositol glycan anchor biosynthesis class C hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGF 266.005005601511 266.929941583326 265.080069619697 0.993069822168857 -0.0100329385078686 0.98689794835094 1 6.76335 6.69031 6.1355 7.11536 GeneID:5281,Genbank:NM_002643.3,HGNC:HGNC:8962,MIM:600153 phosphatidylinositol glycan anchor biosynthesis class F GO:0004307,GO:0005789,GO:0006506,GO:0016021,GO:0016254 ethanolaminephosphotransferase activity|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGG 1855.67637211415 1834.36051442714 1876.99222980116 1.02324064165072 0.0331454722480452 0.812124946110645 1 8.85228 8.38713 9.22591 8.50009 GeneID:54872,Genbank:NM_001345994.1,HGNC:HGNC:25985,MIM:616918 phosphatidylinositol glycan anchor biosynthesis class G GO:0005783,GO:0005789,GO:0006506,GO:0016020,GO:0016254,GO:0016780,GO:0030176,GO:0051267 endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor biosynthetic process|membrane|preassembly of GPI anchor in ER membrane|phosphotransferase activity, for other substituted phosphate groups|integral component of endoplasmic reticulum membrane|CP2 mannose-ethanolamine phosphotransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGH 257.085208852318 278.15355755366 236.016860150976 0.848512822294013 -0.236991633681341 0.261403416047289 1 5.40531 5.75126 5.31677 4.63682 GeneID:5283,Genbank:XM_017021371.2,HGNC:HGNC:8964,MIM:600154 phosphatidylinositol glycan anchor biosynthesis class H hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGK 873.525348982829 874.730737514037 872.319960451621 0.997243978107746 -0.00398158831252434 0.987748736759183 1 8.32539 7.27017 7.99995 7.40858 GeneID:10026,Genbank:NM_005482.2,HGNC:HGNC:8965,MIM:605087 phosphatidylinositol glycan anchor biosynthesis class K GO:0003756,GO:0003923,GO:0005789,GO:0008234,GO:0016020,GO:0016255,GO:0030176,GO:0034394,GO:0042765 protein disulfide isomerase activity|GPI-anchor transamidase activity|endoplasmic reticulum membrane|cysteine-type peptidase activity|membrane|attachment of GPI anchor to protein|integral component of endoplasmic reticulum membrane|protein localization to cell surface|GPI-anchor transamidase complex hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGL 223.750355678701 212.456597727759 235.044113629642 1.10631590707682 0.145763404104651 0.520618794116319 1 0.702979 0.825137 0.879568 0.87784 GeneID:9487,Genbank:NM_004278.3,HGNC:HGNC:8966,MIM:605947 phosphatidylinositol glycan anchor biosynthesis class L GO:0000225,GO:0005789,GO:0006506,GO:0016021,GO:0016254 N-acetylglucosaminylphosphatidylinositol deacetylase activity|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGM 287.01553893496 301.16729613544 272.86378173448 0.906020624536099 -0.142384202919076 0.486978708803678 1 3.49895 3.66677 3.59857 2.97304 GeneID:93183,Genbank:NM_145167.2,HGNC:HGNC:18858,MIM:610273 phosphatidylinositol glycan anchor biosynthesis class M GO:0005789,GO:0016021,GO:0016254,GO:0016758 endoplasmic reticulum membrane|integral component of membrane|preassembly of GPI anchor in ER membrane|transferase activity, transferring hexosyl groups hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGN 255.269735446683 234.278471096669 276.260999796697 1.17919926019453 0.237807524428572 0.255342668928549 1 1.88359 1.84354 2.51866 1.97307 GeneID:23556,Genbank:XM_011525891.1,HGNC:HGNC:8967,MIM:606097 phosphatidylinositol glycan anchor biosynthesis class N GO:0005789,GO:0005829,GO:0005886,GO:0006506,GO:0016020,GO:0016021,GO:0016254,GO:0051377 endoplasmic reticulum membrane|cytosol|plasma membrane|GPI anchor biosynthetic process|membrane|integral component of membrane|preassembly of GPI anchor in ER membrane|mannose-ethanolamine phosphotransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGO 1693.35032323236 1703.6017620022 1683.09888446251 0.9879649821942 -0.0174681876017864 0.892812750708404 1 9.24739 9.86114 9.78861 9.45604 GeneID:84720,Genbank:XM_005251619.3,HGNC:HGNC:23215,MIM:614730 phosphatidylinositol glycan anchor biosynthesis class O GO:0005789,GO:0006506,GO:0016020,GO:0016021,GO:0051377 endoplasmic reticulum membrane|GPI anchor biosynthetic process|membrane|integral component of membrane|mannose-ethanolamine phosphotransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGP 182.965383232332 174.020322966984 191.91044349768 1.10280477719887 0.141177422031094 0.564787520473851 1 4.93147 5.03187 5.01284 4.94655 GeneID:51227,Genbank:NM_153682.2,HGNC:HGNC:3046,MIM:605938 phosphatidylinositol glycan anchor biosynthesis class P GO:0000506,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0017176 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGQ 942.812316992295 889.282043096159 996.342590888431 1.1203898680103 0.164000841901177 0.338452539694219 1 14.7228 16.527 17.066 18.9221 GeneID:9091,Genbank:NM_004204.3,HGNC:HGNC:14135,MIM:605754 phosphatidylinositol glycan anchor biosynthesis class Q GO:0000506,GO:0005789,GO:0005975,GO:0016021,GO:0016254,GO:0017176 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|endoplasmic reticulum membrane|carbohydrate metabolic process|integral component of membrane|preassembly of GPI anchor in ER membrane|phosphatidylinositol N-acetylglucosaminyltransferase activity hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGS 2165.51728839852 2026.18812099971 2304.84645579733 1.13752836269721 0.185902517366257 0.189377912019269 1 29.7604 31.2263 35.1549 34.9888 GeneID:94005,Genbank:NM_033198.3,HGNC:HGNC:14937,MIM:610271 phosphatidylinositol glycan anchor biosynthesis class S GO:0003923,GO:0005789,GO:0016020,GO:0016255,GO:0042765 GPI-anchor transamidase activity|endoplasmic reticulum membrane|membrane|attachment of GPI anchor to protein|GPI-anchor transamidase complex hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGT 4409.01189689206 4430.81889816326 4387.20489562087 0.990156672266504 -0.0142712743227661 0.905587391908481 1 72.7992 73.5075 72.8158 75.2068 GeneID:51604,Genbank:NM_015937.5,HGNC:HGNC:14938,MIM:610272 phosphatidylinositol glycan anchor biosynthesis class T GO:0003923,GO:0005789,GO:0016020,GO:0016255,GO:0030176,GO:0030182,GO:0031410,GO:0042765,GO:0051402 GPI-anchor transamidase activity|endoplasmic reticulum membrane|membrane|attachment of GPI anchor to protein|integral component of endoplasmic reticulum membrane|neuron differentiation|cytoplasmic vesicle|GPI-anchor transamidase complex|neuron apoptotic process hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGU 846.007722012393 834.720421344621 857.295022680166 1.02704450587082 0.0384987006511378 0.812814620915291 1 10.1936 10.6525 11.274 10.1827 GeneID:128869,Genbank:NM_080476.4,HGNC:HGNC:15791,MIM:608528 phosphatidylinositol glycan anchor biosynthesis class U GO:0005789,GO:0005886,GO:0006506,GO:0016020,GO:0016255,GO:0030176,GO:0042765,GO:0046425 endoplasmic reticulum membrane|plasma membrane|GPI anchor biosynthetic process|membrane|attachment of GPI anchor to protein|integral component of endoplasmic reticulum membrane|GPI-anchor transamidase complex|regulation of JAK-STAT cascade hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGV 280.619506660709 253.967571069226 307.271442252193 1.20988455714465 0.274869397268127 0.178529028162059 1 4.14422 3.96071 5.35459 4.54147 GeneID:55650,Genbank:NM_017837.3,HGNC:HGNC:26031,MIM:610274 phosphatidylinositol glycan anchor biosynthesis class V GO:0000030,GO:0004376,GO:0004584,GO:0005789,GO:0006506,GO:0016021,GO:0016254,GO:0031501 mannosyltransferase activity|glycolipid mannosyltransferase activity|dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane|mannosyltransferase complex hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGW 729.57608153764 746.720308402106 712.431854673174 0.954081262631915 -0.0678159437475941 0.679897463532413 1 12.6962 12.787 13.2161 11.3241 GeneID:284098,Genbank:NM_178517.4,HGNC:HGNC:23213,MIM:610275 phosphatidylinositol glycan anchor biosynthesis class W GO:0005789,GO:0006505,GO:0008374,GO:0016021,GO:0016254,GO:0072659 endoplasmic reticulum membrane|GPI anchor metabolic process|O-acyltransferase activity|integral component of membrane|preassembly of GPI anchor in ER membrane|protein localization to plasma membrane hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGX 910.355360637428 915.878134969094 904.832586305762 0.987939936284531 -0.0175047618411018 0.919812053895208 1 11.6542 11.468 12.3013 10.9354 GeneID:54965,Genbank:NM_001166304.1,HGNC:HGNC:26046,MIM:610276 phosphatidylinositol glycan anchor biosynthesis class X GO:0005789,GO:0016021,GO:0016254 endoplasmic reticulum membrane|integral component of membrane|preassembly of GPI anchor in ER membrane hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIGZ 127.310921528489 122.313902733783 132.307940323196 1.08170810812214 0.113311249833319 0.695303880318742 1 0.610902 0.582047 0.709917 0.706555 GeneID:80235,Genbank:NM_025163.3,HGNC:HGNC:30596,MIM:611671 phosphatidylinositol glycan anchor biosynthesis class Z GO:0000026,GO:0000030,GO:0005783,GO:0005789,GO:0006506,GO:0016021,GO:0016254 alpha-1,2-mannosyltransferase activity|mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|GPI anchor biosynthetic process|integral component of membrane|preassembly of GPI anchor in ER membrane hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis PIH1D1 1623.14225715664 1652.94414515867 1593.34036915461 0.963940840845325 -0.0529834870607928 0.739987918672341 1 26.4456 29.0376 26.0795 29.0237 GeneID:55011,Genbank:NM_017916.2,HGNC:HGNC:26075,MIM:611480 PIH1 domain containing 1 GO:0000492,GO:0001164,GO:0005634,GO:0005730,GO:0005737,GO:0006338,GO:0006351,GO:0006364,GO:0019901,GO:0030855,GO:0031334,GO:0042393,GO:0048254,GO:0051117,GO:0051219,GO:0051569,GO:0070761,GO:0071169,GO:0071902,GO:0090240,GO:0097255,GO:1900110,GO:1900113,GO:1901838,GO:1902661,GO:1904263,GO:2000617,GO:2000619,GO:2001268 box C/D snoRNP assembly|RNA polymerase I CORE element sequence-specific DNA binding|nucleus|nucleolus|cytoplasm|chromatin remodeling|transcription, DNA-templated|rRNA processing|protein kinase binding|epithelial cell differentiation|positive regulation of protein complex assembly|histone binding|snoRNA localization|ATPase binding|phosphoprotein binding|regulation of histone H3-K4 methylation|pre-snoRNP complex|establishment of protein localization to chromatin|positive regulation of protein serine/threonine kinase activity|positive regulation of histone H4 acetylation|R2TP complex|negative regulation of histone H3-K9 dimethylation|negative regulation of histone H3-K9 trimethylation|positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|positive regulation of glucose mediated signaling pathway|positive regulation of TORC1 signaling|positive regulation of histone H3-K9 acetylation|negative regulation of histone H4-K16 acetylation|negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway PIH1D2 30.1391033896398 38.4744923803521 21.8037143989275 0.566705706819464 -0.819328364190966 0.195141795317699 1 0.289478 0.179939 0.118846 0.197859 GeneID:120379,Genbank:XM_017017205.2,HGNC:HGNC:25210 PIH1 domain containing 2 GO:0017160 Ral GTPase binding PIK3AP1 197.135666920457 193.603561735063 200.667772105851 1.03648801864738 0.0517034396138341 0.853911870951507 1 1.26617 1.33044 1.61014 1.09534 GeneID:118788,Genbank:NM_152309.2,HGNC:HGNC:30034,MIM:607942 phosphoinositide-3-kinase adaptor protein 1 GO:0005829,GO:0005886,GO:0014068,GO:0016020,GO:0034134,GO:0034142,GO:0034154,GO:0034162,GO:0036312,GO:0042802,GO:0046934,GO:0050727,GO:0051897 cytosol|plasma membrane|positive regulation of phosphatidylinositol 3-kinase signaling|membrane|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway|phosphatidylinositol 3-kinase regulatory subunit binding|identical protein binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|regulation of inflammatory response|positive regulation of protein kinase B signaling hsa04151,hsa04662 PI3K-Akt signaling pathway|B cell receptor signaling pathway PIK3C2A 225.886375658667 236.06525191512 215.707499402213 0.913762180804879 -0.130109362008702 0.769043970676897 1 1.06088 0.836787 1.07981 0.641849 GeneID:5286,Genbank:NM_001321380.1,HGNC:HGNC:8971,MIM:603601 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha GO:0005524,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0005942,GO:0006661,GO:0006887,GO:0006897,GO:0007173,GO:0008286,GO:0014065,GO:0014829,GO:0016020,GO:0016303,GO:0016477,GO:0030136,GO:0031982,GO:0035004,GO:0035005,GO:0035091,GO:0048008,GO:0048268,GO:0061024,GO:0070062 ATP binding|nucleus|cytoplasm|Golgi apparatus|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|exocytosis|endocytosis|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|phosphatidylinositol 3-kinase signaling|vascular smooth muscle contraction|membrane|1-phosphatidylinositol-3-kinase activity|cell migration|clathrin-coated vesicle|vesicle|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|phosphatidylinositol binding|platelet-derived growth factor receptor signaling pathway|clathrin coat assembly|membrane organization|extracellular exosome hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system PIK3C2B 118.293685342964 116.394828290718 120.192542395211 1.03262785950426 0.0463204265379362 0.903709888569491 1 0.400412 0.46921 0.506132 0.448375 GeneID:5287,Genbank:NM_002646.3,HGNC:HGNC:8972,MIM:602838 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta GO:0001727,GO:0005524,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0005942,GO:0006661,GO:0009267,GO:0014065,GO:0016303,GO:0016477,GO:0030139,GO:0035005,GO:0035091,GO:0043491,GO:1905037 lipid kinase activity|ATP binding|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|cellular response to starvation|phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-3-kinase activity|cell migration|endocytic vesicle|1-phosphatidylinositol-4-phosphate 3-kinase activity|phosphatidylinositol binding|protein kinase B signaling|autophagosome organization hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system PIK3C3 240.109070971428 232.078054115415 248.140087827442 1.06920961903636 0.096544721812248 0.655117599722941 1 1.46596 1.55159 1.6734 1.48404 GeneID:5289,Genbank:NM_002647.3,HGNC:HGNC:8974,MIM:602609 phosphatidylinositol 3-kinase catalytic subunit type 3 GO:0000045,GO:0000407,GO:0000910,GO:0004672,GO:0005524,GO:0005770,GO:0005777,GO:0005829,GO:0005930,GO:0006468,GO:0006497,GO:0006661,GO:0006897,GO:0006914,GO:0007032,GO:0016020,GO:0016236,GO:0016301,GO:0016303,GO:0016485,GO:0030242,GO:0030496,GO:0030670,GO:0032465,GO:0034162,GO:0034271,GO:0034272,GO:0034497,GO:0035032,GO:0042149,GO:0043201,GO:0044754,GO:0045022,GO:0048015,GO:0050708 autophagosome assembly|phagophore assembly site|cytokinesis|protein kinase activity|ATP binding|late endosome|peroxisome|cytosol|axoneme|protein phosphorylation|protein lipidation|phosphatidylinositol biosynthetic process|endocytosis|autophagy|endosome organization|membrane|macroautophagy|kinase activity|1-phosphatidylinositol-3-kinase activity|protein processing|autophagy of peroxisome|midbody|phagocytic vesicle membrane|regulation of cytokinesis|toll-like receptor 9 signaling pathway|phosphatidylinositol 3-kinase complex, class III, type I|phosphatidylinositol 3-kinase complex, class III, type II|protein localization to phagophore assembly site|phosphatidylinositol 3-kinase complex, class III|cellular response to glucose starvation|response to leucine|autolysosome|early endosome to late endosome transport|phosphatidylinositol-mediated signaling|regulation of protein secretion hsa00562,hsa04070,hsa04136,hsa04140,hsa04145,hsa04371,hsa05152,hsa05167 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Autophagy - other|Autophagy - animal|Phagosome|Apelin signaling pathway|Tuberculosis|Kaposi sarcoma-associated herpesvirus infection PIK3CA 270.105798825229 262.461464035917 277.750133614541 1.05825110225146 0.0816819913370685 0.813812601267624 1 1.20548 1.05921 1.54133 0.888707 GeneID:5290,Genbank:XM_006713658.4,HGNC:HGNC:8975,MIM:171834 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha hsa00562,hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04960,hsa04973,hsa05100,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05418 Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Bacterial invasion of epithelial cells|Chagas disease (American trypanosomiasis)|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PIK3CB 777.535382810888 844.06018694628 711.010578675495 0.842369524912502 -0.247474851131634 0.120579870896049 1 4.11084 4.44563 3.98374 3.23581 GeneID:5291,Genbank:NM_006219.2,HGNC:HGNC:8976,MIM:602925 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta GO:0000187,GO:0001935,GO:0001952,GO:0002250,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0005942,GO:0006661,GO:0006874,GO:0006914,GO:0006935,GO:0006954,GO:0007156,GO:0007165,GO:0007169,GO:0007186,GO:0007411,GO:0010508,GO:0010628,GO:0014065,GO:0016301,GO:0016303,GO:0016310,GO:0016477,GO:0019221,GO:0030168,GO:0030496,GO:0033031,GO:0035004,GO:0035005,GO:0038095,GO:0038096,GO:0040016,GO:0043560,GO:0045087,GO:0046934,GO:0048010,GO:0048015,GO:0050852,GO:0050900,GO:0051897,GO:0060055,GO:0060326,GO:0070527,GO:2000369 activation of MAPK activity|endothelial cell proliferation|regulation of cell-matrix adhesion|adaptive immune response|ATP binding|nucleus|nucleolus|cytoplasm|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|cellular calcium ion homeostasis|autophagy|chemotaxis|inflammatory response|homophilic cell adhesion via plasma membrane adhesion molecules|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|G-protein coupled receptor signaling pathway|axon guidance|positive regulation of autophagy|positive regulation of gene expression|phosphatidylinositol 3-kinase signaling|kinase activity|1-phosphatidylinositol-3-kinase activity|phosphorylation|cell migration|cytokine-mediated signaling pathway|platelet activation|midbody|positive regulation of neutrophil apoptotic process|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|embryonic cleavage|insulin receptor substrate binding|innate immune response|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|vascular endothelial growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|T cell receptor signaling pathway|leukocyte migration|positive regulation of protein kinase B signaling|angiogenesis involved in wound healing|cell chemotaxis|platelet aggregation|regulation of clathrin-dependent endocytosis hsa00562,hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04960,hsa04973,hsa05100,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05418 Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Bacterial invasion of epithelial cells|Chagas disease (American trypanosomiasis)|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PIK3CD 555.849524982926 592.630233781958 519.068816183894 0.875872992289608 -0.1912064107668 0.250404980822906 1 4.04902 4.36576 4.11982 3.42691 GeneID:5293,Genbank:XM_017001477.1,HGNC:HGNC:8977,MIM:602839 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta hsa00562,hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04960,hsa04973,hsa05100,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05418 Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Bacterial invasion of epithelial cells|Chagas disease (American trypanosomiasis)|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PIK3CG 133.781652694578 128.473108550273 139.090196838882 1.08264054951589 0.114554329272635 0.668458121829764 1 0.499983 0.517669 0.617776 0.50599 GeneID:5294,Genbank:NM_001282426.1,HGNC:HGNC:8978,MIM:601232 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma GO:0001525,GO:0001816,GO:0002250,GO:0002407,GO:0002675,GO:0002679,GO:0004672,GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005944,GO:0006661,GO:0006897,GO:0006954,GO:0007186,GO:0007204,GO:0010818,GO:0010897,GO:0014065,GO:0016020,GO:0016301,GO:0016303,GO:0016310,GO:0030168,GO:0030593,GO:0032252,GO:0033628,GO:0035004,GO:0035005,GO:0035747,GO:0042098,GO:0042110,GO:0042629,GO:0042802,GO:0043303,GO:0043406,GO:0045087,GO:0046875,GO:0046934,GO:0051897,GO:0055118,GO:0070527,GO:0071320,GO:0072672,GO:0097284,GO:1903169,GO:2000270 angiogenesis|cytokine production|adaptive immune response|dendritic cell chemotaxis|positive regulation of acute inflammatory response|respiratory burst involved in defense response|protein kinase activity|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex, class IB|phosphatidylinositol biosynthetic process|endocytosis|inflammatory response|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|T cell chemotaxis|negative regulation of triglyceride catabolic process|phosphatidylinositol 3-kinase signaling|membrane|kinase activity|1-phosphatidylinositol-3-kinase activity|phosphorylation|platelet activation|neutrophil chemotaxis|secretory granule localization|regulation of cell adhesion mediated by integrin|phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-4-phosphate 3-kinase activity|natural killer cell chemotaxis|T cell proliferation|T cell activation|mast cell granule|identical protein binding|mast cell degranulation|positive regulation of MAP kinase activity|innate immune response|ephrin receptor binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|positive regulation of protein kinase B signaling|negative regulation of cardiac muscle contraction|platelet aggregation|cellular response to cAMP|neutrophil extravasation|hepatocyte apoptotic process|regulation of calcium ion transmembrane transport|negative regulation of fibroblast apoptotic process hsa00562,hsa04022,hsa04062,hsa04072,hsa04151,hsa04261,hsa04371,hsa04611,hsa04725,hsa04921,hsa05145,hsa05167 Inositol phosphate metabolism|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Platelet activation|Cholinergic synapse|Oxytocin signaling pathway|Toxoplasmosis|Kaposi sarcoma-associated herpesvirus infection PIK3IP1 5.69630862378641 5.09281911831339 6.29979812925943 1.23699624567577 0.306841121694094 0.882337711803814 1 0.0762264 0.102477 0.0894271 0.0834333 GeneID:113791,Genbank:NM_001135911.1,HGNC:HGNC:24942 phosphoinositide-3-kinase interacting protein 1 GO:0005886,GO:0014067,GO:0016021,GO:0036313,GO:0043553,GO:0070062 plasma membrane|negative regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|phosphatidylinositol 3-kinase catalytic subunit binding|negative regulation of phosphatidylinositol 3-kinase activity|extracellular exosome PIK3R1 500.223229971059 480.827327551633 519.619132390485 1.08067720492589 0.111935658690925 0.715829995880082 1 1.8616 1.64782 2.38485 1.47818 GeneID:5295,Genbank:XM_005248542.3,HGNC:HGNC:8979,MIM:171833 phosphoinositide-3-kinase regulatory subunit 1 hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04960,hsa04973,hsa05100,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05418 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Bacterial invasion of epithelial cells|Chagas disease (American trypanosomiasis)|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PIK3R2 4181.73763074017 4073.54638183382 4289.92887964652 1.05311894784792 0.0746683953177498 0.597343769397404 1 42.5193 44.3876 48.0188 46.0685 GeneID:5296,Genbank:NM_005027.3,HGNC:HGNC:8980,MIM:603157 phosphoinositide-3-kinase regulatory subunit 2 GO:0001678,GO:0001784,GO:0005096,GO:0005634,GO:0005829,GO:0005942,GO:0006661,GO:0008286,GO:0010506,GO:0014065,GO:0015031,GO:0016303,GO:0019903,GO:0030971,GO:0032869,GO:0034976,GO:0038095,GO:0038096,GO:0042993,GO:0043409,GO:0043551,GO:0045944,GO:0046854,GO:0046934,GO:0046935,GO:0046982,GO:0048010,GO:0048015,GO:0050852,GO:0050900,GO:0051056,GO:0051897,GO:2001275 cellular glucose homeostasis|phosphotyrosine residue binding|GTPase activator activity|nucleus|cytosol|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|insulin receptor signaling pathway|regulation of autophagy|phosphatidylinositol 3-kinase signaling|protein transport|1-phosphatidylinositol-3-kinase activity|protein phosphatase binding|receptor tyrosine kinase binding|cellular response to insulin stimulus|response to endoplasmic reticulum stress|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of transcription factor import into nucleus|negative regulation of MAPK cascade|regulation of phosphatidylinositol 3-kinase activity|positive regulation of transcription from RNA polymerase II promoter|phosphatidylinositol phosphorylation|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|1-phosphatidylinositol-3-kinase regulator activity|protein heterodimerization activity|vascular endothelial growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|T cell receptor signaling pathway|leukocyte migration|regulation of small GTPase mediated signal transduction|positive regulation of protein kinase B signaling|positive regulation of glucose import in response to insulin stimulus hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04960,hsa04973,hsa05100,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05418 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Bacterial invasion of epithelial cells|Chagas disease (American trypanosomiasis)|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PIK3R3 78.4852098092028 71.1837977968017 85.7866218216039 1.20514252507975 0.269203775556095 0.408628840269634 1 4.35221 3.65633 5.55942 3.77306 GeneID:8503,Genbank:NM_001328648.1,HGNC:HGNC:8981,MIM:606076 phosphoinositide-3-kinase regulatory subunit 3 GO:0001784,GO:0005829,GO:0005942,GO:0006661,GO:0008286,GO:0016303,GO:0043551,GO:0046935,GO:2001275 phosphotyrosine residue binding|cytosol|phosphatidylinositol 3-kinase complex|phosphatidylinositol biosynthetic process|insulin receptor signaling pathway|1-phosphatidylinositol-3-kinase activity|regulation of phosphatidylinositol 3-kinase activity|1-phosphatidylinositol-3-kinase regulator activity|positive regulation of glucose import in response to insulin stimulus hsa01521,hsa01522,hsa01524,hsa04012,hsa04014,hsa04015,hsa04024,hsa04062,hsa04066,hsa04068,hsa04070,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04210,hsa04211,hsa04213,hsa04218,hsa04360,hsa04370,hsa04380,hsa04510,hsa04550,hsa04611,hsa04620,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04668,hsa04670,hsa04722,hsa04725,hsa04750,hsa04810,hsa04910,hsa04914,hsa04915,hsa04917,hsa04919,hsa04923,hsa04926,hsa04930,hsa04931,hsa04932,hsa04933,hsa04960,hsa04973,hsa05100,hsa05142,hsa05146,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05220,hsa05221,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231,hsa05418 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|Platinum drug resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Apoptosis|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Signaling pathways regulating pluripotency of stem cells|Platelet activation|Toll-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|TNF signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Cholinergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Regulation of lipolysis in adipocytes|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Aldosterone-regulated sodium reabsorption|Carbohydrate digestion and absorption|Bacterial invasion of epithelial cells|Chagas disease (American trypanosomiasis)|Amoebiasis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer|Fluid shear stress and atherosclerosis PIK3R4 358.539611753316 370.525078493359 346.554145013273 0.935305503266992 -0.0964904185944511 0.673498357224477 1 2.72983 2.51854 2.88305 2.09495 GeneID:30849,Genbank:NM_014602.2,HGNC:HGNC:8982,MIM:602610 phosphoinositide-3-kinase regulatory subunit 4 GO:0004672,GO:0004674,GO:0005524,GO:0005643,GO:0005770,GO:0005776,GO:0005829,GO:0005930,GO:0006468,GO:0006623,GO:0006661,GO:0015630,GO:0016020,GO:0016236,GO:0016303,GO:0030242,GO:0030670,GO:0032465,GO:0032801,GO:0034162,GO:0034271,GO:0034272,GO:0035032,GO:0042149,GO:0043231,GO:0043552,GO:0045324,GO:0071561 protein kinase activity|protein serine/threonine kinase activity|ATP binding|nuclear pore|late endosome|autophagosome|cytosol|axoneme|protein phosphorylation|protein targeting to vacuole|phosphatidylinositol biosynthetic process|microtubule cytoskeleton|membrane|macroautophagy|1-phosphatidylinositol-3-kinase activity|autophagy of peroxisome|phagocytic vesicle membrane|regulation of cytokinesis|receptor catabolic process|toll-like receptor 9 signaling pathway|phosphatidylinositol 3-kinase complex, class III, type I|phosphatidylinositol 3-kinase complex, class III, type II|phosphatidylinositol 3-kinase complex, class III|cellular response to glucose starvation|intracellular membrane-bounded organelle|positive regulation of phosphatidylinositol 3-kinase activity|late endosome to vacuole transport|nucleus-vacuole junction hsa04136,hsa04140,hsa04371 Autophagy - other|Autophagy - animal|Apelin signaling pathway PIK3R5 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0083892 0 GeneID:23533,Genbank:NM_001251852.1,HGNC:HGNC:30035,MIM:611317 phosphoinositide-3-kinase regulatory subunit 5 GO:0005634,GO:0005737,GO:0005815,GO:0005829,GO:0005886,GO:0005942,GO:0005944,GO:0006661,GO:0007186,GO:0014065,GO:0016020,GO:0030168,GO:0031683,GO:0043406,GO:0046934,GO:0046935,GO:0051897 nucleus|cytoplasm|microtubule organizing center|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol 3-kinase complex, class IB|phosphatidylinositol biosynthetic process|G-protein coupled receptor signaling pathway|phosphatidylinositol 3-kinase signaling|membrane|platelet activation|G-protein beta/gamma-subunit complex binding|positive regulation of MAP kinase activity|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|1-phosphatidylinositol-3-kinase regulator activity|positive regulation of protein kinase B signaling hsa04022,hsa04062,hsa04072,hsa04151,hsa04261,hsa04371,hsa04611,hsa04725,hsa04921,hsa05145,hsa05167 cGMP-PKG signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Platelet activation|Cholinergic synapse|Oxytocin signaling pathway|Toxoplasmosis|Kaposi sarcoma-associated herpesvirus infection PIK3R6 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00998217 0 0 0.00868917 GeneID:146850,Genbank:NM_001010855.3,HGNC:HGNC:27101,MIM:611462 phosphoinositide-3-kinase regulatory subunit 6 GO:0001525,GO:0005829,GO:0005886,GO:0005942,GO:0005944,GO:0006661,GO:0007186,GO:0014065,GO:0016020,GO:0030168,GO:0042269,GO:0043406,GO:0045582,GO:0045766,GO:0046934,GO:0046935 angiogenesis|cytosol|plasma membrane|phosphatidylinositol 3-kinase complex|phosphatidylinositol 3-kinase complex, class IB|phosphatidylinositol biosynthetic process|G-protein coupled receptor signaling pathway|phosphatidylinositol 3-kinase signaling|membrane|platelet activation|regulation of natural killer cell mediated cytotoxicity|positive regulation of MAP kinase activity|positive regulation of T cell differentiation|positive regulation of angiogenesis|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|1-phosphatidylinositol-3-kinase regulator activity hsa04022,hsa04062,hsa04072,hsa04151,hsa04261,hsa04371,hsa04611,hsa04725,hsa04921,hsa05145,hsa05167 cGMP-PKG signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|PI3K-Akt signaling pathway|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Platelet activation|Cholinergic synapse|Oxytocin signaling pathway|Toxoplasmosis|Kaposi sarcoma-associated herpesvirus infection PIKFYVE 350.192511401602 365.442068030154 334.94295477305 0.9165418655233 -0.125727313627514 0.677414374547859 1 1.2183 1.15622 1.34305 0.841528 GeneID:200576,Genbank:XM_011510779.2,HGNC:HGNC:23785,MIM:609414 phosphoinositide kinase, FYVE-type zinc finger containing GO:0000139,GO:0000285,GO:0005524,GO:0005829,GO:0005911,GO:0006661,GO:0008270,GO:0010008,GO:0012506,GO:0016308,GO:0031901,GO:0031902,GO:0032288,GO:0034504,GO:0035556,GO:0042147,GO:0043813,GO:0045121,GO:0048471,GO:1904562,GO:2000785 Golgi membrane|1-phosphatidylinositol-3-phosphate 5-kinase activity|ATP binding|cytosol|cell-cell junction|phosphatidylinositol biosynthetic process|zinc ion binding|endosome membrane|vesicle membrane|1-phosphatidylinositol-4-phosphate 5-kinase activity|early endosome membrane|late endosome membrane|myelin assembly|protein localization to nucleus|intracellular signal transduction|retrograde transport, endosome to Golgi|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|membrane raft|perinuclear region of cytoplasm|phosphatidylinositol 5-phosphate metabolic process|regulation of autophagosome assembly hsa00562,hsa04070,hsa04145,hsa04810 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Phagosome|Regulation of actin cytoskeleton PILRA 3.93596897796249 2.05633815719933 5.81559979872566 2.82813397123668 1.499850463521 0.373295775265205 1 0 0.0503125 0.104862 0.0984237 GeneID:29992,Genbank:XM_024446739.1,HGNC:HGNC:20396,MIM:605341 paired immunoglobin like type 2 receptor alpha GO:0005886,GO:0007165,GO:0007169,GO:0016021,GO:0016032,GO:0042288,GO:0050776,GO:0070062 plasma membrane|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|integral component of membrane|viral process|MHC class I protein binding|regulation of immune response|extracellular exosome hsa05168 Herpes simplex infection PILRB 385.453220861043 381.758503118802 389.147938603284 1.01935630882905 0.0276584235643926 0.88705866231394 1 8.39716 7.93432 8.44524 8.91605 GeneID:29990,Genbank:NM_178238.3,HGNC:HGNC:18297,MIM:605342 paired immunoglobin-like type 2 receptor beta GO:0005886,GO:0005887,GO:0007169,GO:0007171,GO:0042288,GO:0050776 plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|activation of transmembrane receptor protein tyrosine kinase activity|MHC class I protein binding|regulation of immune response PIM1 875.831369786721 879.307110267633 872.35562930581 0.99209436511925 -0.0114507428087344 0.928389387959626 1 16.9529 18.1548 18.6323 16.7333 GeneID:5292,Genbank:NM_002648.3,HGNC:HGNC:8986,MIM:164960 Pim-1 proto-oncogene, serine/threonine kinase hsa04630,hsa04933,hsa05200,hsa05206,hsa05221 Jak-STAT signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer|MicroRNAs in cancer|Acute myeloid leukemia PIM2 357.978826335573 366.057617946805 349.90003472434 0.955860546454157 -0.0651279407130928 0.726478967009786 1 6.51588 6.91622 6.73639 6.49924 GeneID:11040,Genbank:NM_006875.3,HGNC:HGNC:8987,MIM:300295 Pim-2 proto-oncogene, serine/threonine kinase GO:0000082,GO:0004672,GO:0004674,GO:0005524,GO:0005737,GO:0006468,GO:0007346,GO:0008285,GO:0008637,GO:0009615,GO:0010508,GO:0016239,GO:0032091,GO:0043066,GO:0043123,GO:0045893,GO:0046777,GO:0050821 G1/S transition of mitotic cell cycle|protein kinase activity|protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation|regulation of mitotic cell cycle|negative regulation of cell proliferation|apoptotic mitochondrial changes|response to virus|positive regulation of autophagy|positive regulation of macroautophagy|negative regulation of protein binding|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|protein autophosphorylation|protein stabilization hsa05200,hsa05221 Pathways in cancer|Acute myeloid leukemia PIM3 933.71758500098 964.125646424124 903.309523577835 0.936920957271646 -0.0940007538997033 0.542957690400733 1 30.8909 28.2973 27.5457 28.6272 GeneID:415116,Genbank:NM_001001852.3,HGNC:HGNC:19310,MIM:610580 Pim-3 proto-oncogene, serine/threonine kinase GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006915,GO:0007049,GO:0007346,GO:0043066,GO:0046777,GO:0061179 protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|apoptotic process|cell cycle|regulation of mitotic cell cycle|negative regulation of apoptotic process|protein autophosphorylation|negative regulation of insulin secretion involved in cellular response to glucose stimulus PIMREG 2764.06723765343 2631.70429005662 2896.43018525024 1.10059104899963 0.138278500528635 0.352141416294524 1 34.3308 37.5675 37.6526 42.7104 GeneID:54478,Genbank:NM_019013.2,HGNC:HGNC:25483,MIM:617611 PICALM interacting mitotic regulator GO:0005634,GO:0005730,GO:0007049,GO:0051301 nucleus|nucleolus|cell cycle|cell division PIN1 2922.7031241154 2847.21698605571 2998.18926217509 1.05302450668803 0.0745390121146974 0.640939068231544 1 78.8925 81.6078 84.3154 92.7392 GeneID:5300,Genbank:NM_006221.3,HGNC:HGNC:8988,MIM:601052 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 GO:0000413,GO:0001934,GO:0003755,GO:0003774,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0007049,GO:0007088,GO:0008013,GO:0016607,GO:0030182,GO:0030496,GO:0030512,GO:0031434,GO:0032091,GO:0032465,GO:0032480,GO:0032794,GO:0035307,GO:0042177,GO:0043005,GO:0043524,GO:0043525,GO:0043547,GO:0045944,GO:0050808,GO:0050815,GO:0050816,GO:0050821,GO:0051443,GO:0060393,GO:0061051,GO:0070373,GO:0090263,GO:1900180,GO:1901796,GO:2000146 protein peptidyl-prolyl isomerization|positive regulation of protein phosphorylation|peptidyl-prolyl cis-trans isomerase activity|motor activity|nucleus|nucleoplasm|mitochondrion|cytosol|cell cycle|regulation of mitotic nuclear division|beta-catenin binding|nuclear speck|neuron differentiation|midbody|negative regulation of transforming growth factor beta receptor signaling pathway|mitogen-activated protein kinase kinase binding|negative regulation of protein binding|regulation of cytokinesis|negative regulation of type I interferon production|GTPase activating protein binding|positive regulation of protein dephosphorylation|negative regulation of protein catabolic process|neuron projection|negative regulation of neuron apoptotic process|positive regulation of neuron apoptotic process|positive regulation of GTPase activity|positive regulation of transcription from RNA polymerase II promoter|synapse organization|phosphoserine residue binding|phosphothreonine residue binding|protein stabilization|positive regulation of ubiquitin-protein transferase activity|regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of cell growth involved in cardiac muscle cell development|negative regulation of ERK1 and ERK2 cascade|positive regulation of canonical Wnt signaling pathway|regulation of protein localization to nucleus|regulation of signal transduction by p53 class mediator|negative regulation of cell motility hsa04622 RIG-I-like receptor signaling pathway PIN4 758.320879463402 770.868077266964 745.77368165984 0.967446575688938 -0.0477460999008155 0.772609706991345 1 9.9667 10.4398 8.99123 10.7012 GeneID:5303,Genbank:NM_001170747.1,HGNC:HGNC:8992,MIM:300252 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 GO:0003677,GO:0003681,GO:0003690,GO:0003723,GO:0003755,GO:0005634,GO:0005730,GO:0005737,GO:0005759,GO:0005819,GO:0006364,GO:0030684,GO:0070062 DNA binding|bent DNA binding|double-stranded DNA binding|RNA binding|peptidyl-prolyl cis-trans isomerase activity|nucleus|nucleolus|cytoplasm|mitochondrial matrix|spindle|rRNA processing|preribosome|extracellular exosome PINK1 1710.07890828716 1552.88435226596 1867.27346430835 1.20245494236814 0.265982835251091 0.0666892665249535 0.911344106368307 25.7193 28.1331 33.8506 32.1655 GeneID:65018,Genbank:NM_032409.2,HGNC:HGNC:14581,MIM:608309 PTEN induced putative kinase 1 GO:0000287,GO:0000422,GO:0000785,GO:0001934,GO:0002020,GO:0002082,GO:0002931,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005758,GO:0005829,GO:0005856,GO:0006468,GO:0006511,GO:0006950,GO:0006979,GO:0007005,GO:0010310,GO:0010629,GO:0010821,GO:0010857,GO:0010952,GO:0016020,GO:0016236,GO:0016239,GO:0016242,GO:0016301,GO:0016504,GO:0016567,GO:0018105,GO:0022904,GO:0030424,GO:0030426,GO:0031307,GO:0031396,GO:0031398,GO:0031625,GO:0032148,GO:0032226,GO:0033138,GO:0033603,GO:0034599,GO:0035307,GO:0035556,GO:0036289,GO:0038203,GO:0043123,GO:0043254,GO:0043422,GO:0043524,GO:0044297,GO:0045727,GO:0046329,GO:0048471,GO:0050821,GO:0051091,GO:0051443,GO:0051881,GO:0051897,GO:0055131,GO:0061136,GO:0071456,GO:0072655,GO:0072656,GO:0090141,GO:0090200,GO:0090258,GO:0097237,GO:0097413,GO:0097449,GO:0098779,GO:0099074,GO:1900407,GO:1901727,GO:1902803,GO:1902902,GO:1902958,GO:1903146,GO:1903147,GO:1903202,GO:1903204,GO:1903214,GO:1903298,GO:1903384,GO:1903751,GO:1903852,GO:1903955,GO:1904544,GO:1904783,GO:1904881,GO:2000377,GO:2000378,GO:2001171 magnesium ion binding|autophagy of mitochondrion|chromatin|positive regulation of protein phosphorylation|protease binding|regulation of oxidative phosphorylation|response to ischemia|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrial intermembrane space|cytosol|cytoskeleton|protein phosphorylation|ubiquitin-dependent protein catabolic process|response to stress|response to oxidative stress|mitochondrion organization|regulation of hydrogen peroxide metabolic process|negative regulation of gene expression|regulation of mitochondrion organization|calcium-dependent protein kinase activity|positive regulation of peptidase activity|membrane|macroautophagy|positive regulation of macroautophagy|negative regulation of macroautophagy|kinase activity|peptidase activator activity|protein ubiquitination|peptidyl-serine phosphorylation|respiratory electron transport chain|axon|growth cone|integral component of mitochondrial outer membrane|regulation of protein ubiquitination|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|activation of protein kinase B activity|positive regulation of synaptic transmission, dopaminergic|positive regulation of peptidyl-serine phosphorylation|positive regulation of dopamine secretion|cellular response to oxidative stress|positive regulation of protein dephosphorylation|intracellular signal transduction|peptidyl-serine autophosphorylation|TORC2 signaling|positive regulation of I-kappaB kinase/NF-kappaB signaling|regulation of protein complex assembly|protein kinase B binding|negative regulation of neuron apoptotic process|cell body|positive regulation of translation|negative regulation of JNK cascade|perinuclear region of cytoplasm|protein stabilization|positive regulation of DNA binding transcription factor activity|positive regulation of ubiquitin-protein transferase activity|regulation of mitochondrial membrane potential|positive regulation of protein kinase B signaling|C3HC4-type RING finger domain binding|regulation of proteasomal protein catabolic process|cellular response to hypoxia|establishment of protein localization to mitochondrion|maintenance of protein location in mitochondrion|positive regulation of mitochondrial fission|positive regulation of release of cytochrome c from mitochondria|negative regulation of mitochondrial fission|cellular response to toxic substance|Lewy body|astrocyte projection|positive regulation of mitophagy in response to mitochondrial depolarization|mitochondrion to lysosome transport|regulation of cellular response to oxidative stress|positive regulation of histone deacetylase activity|regulation of synaptic vesicle transport|negative regulation of autophagosome assembly|positive regulation of mitochondrial electron transport, NADH to ubiquinone|regulation of autophagy of mitochondrion|negative regulation of autophagy of mitochondrion|negative regulation of oxidative stress-induced cell death|negative regulation of oxidative stress-induced neuron death|regulation of protein targeting to mitochondrion|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide|positive regulation of cristae formation|positive regulation of protein targeting to mitochondrion|positive regulation of free ubiquitin chain polymerization|positive regulation of NMDA glutamate receptor activity|cellular response to hydrogen sulfide|regulation of reactive oxygen species metabolic process|negative regulation of reactive oxygen species metabolic process|positive regulation of ATP biosynthetic process hsa04137,hsa05012 Mitophagy - animal|Parkinson disease PINLYP 30.4712928556957 35.2557149756063 25.6868707357851 0.728587429117749 -0.456825991524947 0.377225227066591 1 0.208063 0.132065 0.115288 0.129005 GeneID:390940,Genbank:XM_011526970.2,HGNC:HGNC:44206 phospholipase A2 inhibitor and LY6/PLAUR domain containing GO:0004859,GO:0005576 phospholipase inhibitor activity|extracellular region PINX1 334.209690570707 353.921502757457 314.497878383957 0.888609129238139 -0.170379131753564 0.369662018726548 1 6.23157 6.68523 5.32059 6.24864 GeneID:54984,Genbank:NM_001284356.1,HGNC:HGNC:30046,MIM:606505 PIN2 (TERF1) interacting telomerase inhibitor 1 GO:0000228,GO:0000776,GO:0000777,GO:0000781,GO:0000784,GO:0005730,GO:0005819,GO:0007004,GO:0007080,GO:0008285,GO:0010521,GO:0010972,GO:0031397,GO:0031647,GO:0032211,GO:0044877,GO:0051972,GO:0051974,GO:0070034,GO:0070198,GO:1902570,GO:1904357,GO:1904744,GO:1904751 nuclear chromosome|kinetochore|condensed chromosome kinetochore|chromosome, telomeric region|nuclear chromosome, telomeric region|nucleolus|spindle|telomere maintenance via telomerase|mitotic metaphase plate congression|negative regulation of cell proliferation|telomerase inhibitor activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of protein ubiquitination|regulation of protein stability|negative regulation of telomere maintenance via telomerase|macromolecular complex binding|regulation of telomerase activity|negative regulation of telomerase activity|telomerase RNA binding|protein localization to chromosome, telomeric region|protein localization to nucleolus|negative regulation of telomere maintenance via telomere lengthening|positive regulation of telomeric DNA binding|positive regulation of protein localization to nucleolus PIP4K2A 1160.15399801893 1154.17322983079 1166.13476620706 1.01036372709669 0.0148747512085372 0.919241667180293 1 9.48918 9.10313 11.1616 8.44969 GeneID:5305,Genbank:NM_005028.4,HGNC:HGNC:8997,MIM:603140 phosphatidylinositol-5-phosphate 4-kinase type 2 alpha GO:0005524,GO:0005654,GO:0005776,GO:0005829,GO:0005886,GO:0006644,GO:0006661,GO:0010506,GO:0014066,GO:0016308,GO:0016309,GO:0035855,GO:0052811,GO:2000786 ATP binding|nucleoplasm|autophagosome|cytosol|plasma membrane|phospholipid metabolic process|phosphatidylinositol biosynthetic process|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|megakaryocyte development|1-phosphatidylinositol-3-phosphate 4-kinase activity|positive regulation of autophagosome assembly hsa00562,hsa04070,hsa04810 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Regulation of actin cytoskeleton PIP4K2B 2883.4608523918 2799.95739205799 2966.96431272561 1.05964623645393 0.0835827005448534 0.546355668506003 1 16.4718 17.0315 18.8216 16.7901 GeneID:8396,Genbank:NM_003559.4,HGNC:HGNC:8998,MIM:603261 phosphatidylinositol-5-phosphate 4-kinase type 2 beta GO:0005057,GO:0005524,GO:0005654,GO:0005776,GO:0005789,GO:0005829,GO:0005886,GO:0006644,GO:0006661,GO:0007166,GO:0010506,GO:0014066,GO:0016308,GO:0016309,GO:0042803,GO:0052811,GO:2000786 signal transducer activity, downstream of receptor|ATP binding|nucleoplasm|autophagosome|endoplasmic reticulum membrane|cytosol|plasma membrane|phospholipid metabolic process|phosphatidylinositol biosynthetic process|cell surface receptor signaling pathway|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|protein homodimerization activity|1-phosphatidylinositol-3-phosphate 4-kinase activity|positive regulation of autophagosome assembly hsa00562,hsa04070,hsa04810 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Regulation of actin cytoskeleton PIP4K2C 1848.5977709367 1869.17520127633 1828.02034059708 0.977982341809831 -0.0321196783942854 0.81540166944292 1 18.6734 19.5419 19.2284 18.3665 GeneID:79837,Genbank:NM_024779.4,HGNC:HGNC:23786,MIM:617104 phosphatidylinositol-5-phosphate 4-kinase type 2 gamma GO:0005524,GO:0005776,GO:0005829,GO:0006661,GO:0010506,GO:0014066,GO:0016020,GO:0016309,GO:0042802,GO:0070062,GO:2000786 ATP binding|autophagosome|cytosol|phosphatidylinositol biosynthetic process|regulation of autophagy|regulation of phosphatidylinositol 3-kinase signaling|membrane|1-phosphatidylinositol-5-phosphate 4-kinase activity|identical protein binding|extracellular exosome|positive regulation of autophagosome assembly hsa00562,hsa04070,hsa04810 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Regulation of actin cytoskeleton PIP4P1 782.491779413611 825.467916638079 739.515642189144 0.895874481955644 -0.158631479730715 0.303473098995146 1 17.3779 19.8916 17.3395 16.7517 GeneID:90809,Genbank:NM_144568.3,HGNC:HGNC:19299,MIM:609865 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 GO:0005765,GO:0016021,GO:0031902,GO:0034597,GO:0046856 lysosomal membrane|integral component of membrane|late endosome membrane|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|phosphatidylinositol dephosphorylation hsa04070 Phosphatidylinositol signaling system PIP4P2 296.725704104257 275.011215388068 318.440192820446 1.15791711392968 0.211531985967588 0.304486250701678 1 4.12641 4.22077 5.44069 4.02312 GeneID:55529,Genbank:NM_018710.2,HGNC:HGNC:25452,MIM:609864 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 GO:0005765,GO:0016021,GO:0031902,GO:0034597,GO:0046856 lysosomal membrane|integral component of membrane|late endosome membrane|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity|phosphatidylinositol dephosphorylation hsa04070 Phosphatidylinositol signaling system PIP5K1A 3920.89124947555 4161.50319215248 3680.27930679862 0.884362966184593 -0.177289483144022 0.187596335182035 1 34.7171 34.6428 31.5348 30.1355 GeneID:8394,Genbank:XM_024450130.1,HGNC:HGNC:8994,MIM:603275 phosphatidylinositol-4-phosphate 5-kinase type 1 alpha GO:0000285,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0005925,GO:0006650,GO:0006661,GO:0006909,GO:0007165,GO:0008654,GO:0010761,GO:0014066,GO:0016308,GO:0016477,GO:0016607,GO:0019900,GO:0030027,GO:0030216,GO:0031532,GO:0032587,GO:0048041,GO:0052810,GO:0052811,GO:0052812,GO:0060326,GO:0072659,GO:0090630,GO:0097178 1-phosphatidylinositol-3-phosphate 5-kinase activity|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|focal adhesion|glycerophospholipid metabolic process|phosphatidylinositol biosynthetic process|phagocytosis|signal transduction|phospholipid biosynthetic process|fibroblast migration|regulation of phosphatidylinositol 3-kinase signaling|1-phosphatidylinositol-4-phosphate 5-kinase activity|cell migration|nuclear speck|kinase binding|lamellipodium|keratinocyte differentiation|actin cytoskeleton reorganization|ruffle membrane|focal adhesion assembly|1-phosphatidylinositol-5-kinase activity|1-phosphatidylinositol-3-phosphate 4-kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|cell chemotaxis|protein localization to plasma membrane|activation of GTPase activity|ruffle assembly hsa00562,hsa04070,hsa04072,hsa04144,hsa04666,hsa04810,hsa05231 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Choline metabolism in cancer PIP5K1B 65.6670297971684 51.3604276552984 79.9736319390385 1.55710603649517 0.638867193046893 0.0740504054244473 0.937542524330394 0.274302 0.278716 0.513757 0.385136 GeneID:8395,Genbank:XM_005252261.3,HGNC:HGNC:8995,MIM:602745 phosphatidylinositol-4-phosphate 5-kinase type 1 beta GO:0000285,GO:0001931,GO:0005524,GO:0005829,GO:0006661,GO:0012505,GO:0014066,GO:0016020,GO:0016308,GO:0052810,GO:0052811,GO:0052812 1-phosphatidylinositol-3-phosphate 5-kinase activity|uropod|ATP binding|cytosol|phosphatidylinositol biosynthetic process|endomembrane system|regulation of phosphatidylinositol 3-kinase signaling|membrane|1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-kinase activity|1-phosphatidylinositol-3-phosphate 4-kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity hsa00562,hsa04070,hsa04072,hsa04144,hsa04666,hsa04810,hsa05231 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Choline metabolism in cancer PIP5K1C 1793.95699249976 1670.61410759275 1917.29987740678 1.14766173031394 0.198697474842281 0.168143808223728 1 8.12124 8.26604 10.0836 8.91084 GeneID:23396,Genbank:XM_017026540.2,HGNC:HGNC:8996,MIM:606102 phosphatidylinositol-4-phosphate 5-kinase type 1 gamma GO:0001891,GO:0001931,GO:0005524,GO:0005654,GO:0005829,GO:0005925,GO:0006661,GO:0006909,GO:0010008,GO:0014066,GO:0016079,GO:0016308,GO:0030036,GO:0030593,GO:0032587,GO:0034333,GO:0048488,GO:0052811,GO:0052812,GO:0061024,GO:0072583,GO:0098609,GO:0098793 phagocytic cup|uropod|ATP binding|nucleoplasm|cytosol|focal adhesion|phosphatidylinositol biosynthetic process|phagocytosis|endosome membrane|regulation of phosphatidylinositol 3-kinase signaling|synaptic vesicle exocytosis|1-phosphatidylinositol-4-phosphate 5-kinase activity|actin cytoskeleton organization|neutrophil chemotaxis|ruffle membrane|adherens junction assembly|synaptic vesicle endocytosis|1-phosphatidylinositol-3-phosphate 4-kinase activity|phosphatidylinositol-3,4-bisphosphate 5-kinase activity|membrane organization|clathrin-dependent endocytosis|cell-cell adhesion|presynapse hsa00562,hsa04070,hsa04072,hsa04144,hsa04510,hsa04666,hsa04810,hsa05231 Inositol phosphate metabolism|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Endocytosis|Focal adhesion|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Choline metabolism in cancer PIP5KL1 26.9417910507176 22.8696597577253 31.01392234371 1.35611647362762 0.43948109345114 0.449297419650493 1 0.240563 0.348889 0.356954 0.403375 GeneID:138429,Genbank:XM_017014279.1,HGNC:HGNC:28711,MIM:612865 phosphatidylinositol-4-phosphate 5-kinase like 1 GO:0005524,GO:0005829,GO:0016020,GO:0016308,GO:0042995 ATP binding|cytosol|membrane|1-phosphatidylinositol-4-phosphate 5-kinase activity|cell projection hsa00562,hsa04144 Inositol phosphate metabolism|Endocytosis PIPOX 2420.16388344833 2123.78571422582 2716.54205267083 1.27910364707444 0.355133172008292 0.085787959152725 0.964561165794104 25.232 25.1431 30.2999 36.0631 GeneID:51268,Genbank:NM_016518.2,HGNC:HGNC:17804,MIM:616713 pipecolic acid and sarcosine oxidase GO:0005102,GO:0005777,GO:0005782,GO:0006554,GO:0008115,GO:0033514,GO:0046653,GO:0050031,GO:0055114 receptor binding|peroxisome|peroxisomal matrix|lysine catabolic process|sarcosine oxidase activity|L-lysine catabolic process to acetyl-CoA via L-pipecolate|tetrahydrofolate metabolic process|L-pipecolate oxidase activity|oxidation-reduction process hsa00260,hsa00310,hsa04146 Glycine, serine and threonine metabolism|Lysine degradation|Peroxisome PIR 449.994145937815 396.008791395142 503.979500480487 1.2726472528677 0.347832594368692 0.0519111407105227 0.833910561303642 7.26599 7.71705 9.04004 9.80876 GeneID:8544,Genbank:NM_001018109.2,HGNC:HGNC:30048,MIM:300931 pirin GO:0003712,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006366,GO:0007586,GO:0008127,GO:0030224,GO:0046872 transcription cofactor activity|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|digestion|quercetin 2,3-dioxygenase activity|monocyte differentiation|metal ion binding PISD 667.236176236624 700.069506668497 634.402845804752 0.906199798393961 -0.142098924998391 0.368321461084649 1 6.52671 7.54363 6.97816 6.29195 GeneID:23761,Genbank:NM_001326420.1,HGNC:HGNC:8999,MIM:612770 phosphatidylserine decarboxylase GO:0004609,GO:0005634,GO:0005743,GO:0008654,GO:0016021 phosphatidylserine decarboxylase activity|nucleus|mitochondrial inner membrane|phospholipid biosynthetic process|integral component of membrane hsa00564 Glycerophospholipid metabolism PITHD1 1423.40885528975 1274.7385693657 1572.07914121379 1.23325611932809 0.302472445899113 0.0377633077393299 0.744558420459959 36.2671 36.6181 44.6625 45.8918 GeneID:57095,Genbank:NM_020362.4,HGNC:HGNC:25022 PITH domain containing 1 GO:0005634,GO:0006974 nucleus|cellular response to DNA damage stimulus PITPNA 2616.26003909625 2624.27576678725 2608.24431140525 0.993891093464762 -0.00884031908191307 0.936867528795087 1 25.1249 27.3946 26.7594 25.936 GeneID:5306,Genbank:NM_006224.3,HGNC:HGNC:9001,MIM:600174 phosphatidylinositol transfer protein alpha GO:0005829,GO:0006629,GO:0007409,GO:0007601,GO:0008525,GO:0008526,GO:0015914,GO:0031210,GO:0035091,GO:0035722,GO:0043209,GO:0070062,GO:1901611 cytosol|lipid metabolic process|axonogenesis|visual perception|phosphatidylcholine transporter activity|phosphatidylinositol transporter activity|phospholipid transport|phosphatidylcholine binding|phosphatidylinositol binding|interleukin-12-mediated signaling pathway|myelin sheath|extracellular exosome|phosphatidylglycerol binding PITPNB 1607.53174468918 1718.95563759544 1496.10785178293 0.870358617210013 -0.200318132238917 0.165015125930025 1 16.3275 16.437 15.5637 13.3702 GeneID:23760,Genbank:NM_001284277.1,HGNC:HGNC:9002,MIM:606876 phosphatidylinositol transfer protein beta GO:0005548,GO:0005737,GO:0008289 phospholipid transporter activity|cytoplasm|lipid binding PITPNC1 179.69805241813 179.122950740406 180.273154095855 1.00642130643055 0.00923437021171546 1 1 0.969012 1.15569 0.966196 0.965995 GeneID:26207,Genbank:NM_181671.2,HGNC:HGNC:21045,MIM:605134 phosphatidylinositol transfer protein cytoplasmic 1 GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0008526,GO:0015914,GO:0035091,GO:0070300,GO:1901611 nucleoplasm|cytoplasm|cytosol|signal transduction|phosphatidylinositol transporter activity|phospholipid transport|phosphatidylinositol binding|phosphatidic acid binding|phosphatidylglycerol binding PITPNM1 1345.22635363322 1243.90533966453 1446.54736760191 1.16290791708638 0.217736863945833 0.197186715582061 1 9.57603 10.9885 11.964 12.4658 GeneID:9600,Genbank:XM_011545396.3,HGNC:HGNC:9003,MIM:608794 phosphatidylinositol transfer protein membrane associated 1 GO:0005789,GO:0005811,GO:0005815,GO:0005829,GO:0006629,GO:0006661,GO:0007420,GO:0007602,GO:0008526,GO:0015031,GO:0015914,GO:0016020,GO:0030496,GO:0031210,GO:0032154,GO:0032580,GO:0035091,GO:0036464,GO:0046872,GO:0070300 endoplasmic reticulum membrane|lipid droplet|microtubule organizing center|cytosol|lipid metabolic process|phosphatidylinositol biosynthetic process|brain development|phototransduction|phosphatidylinositol transporter activity|protein transport|phospholipid transport|membrane|midbody|phosphatidylcholine binding|cleavage furrow|Golgi cisterna membrane|phosphatidylinositol binding|cytoplasmic ribonucleoprotein granule|metal ion binding|phosphatidic acid binding PITPNM2 565.058084577372 572.277557618066 557.838611536678 0.974769330215419 -0.0368672355394863 0.83035469682601 1 2.52125 2.54941 2.72641 2.29857 GeneID:57605,Genbank:XM_024449098.1,HGNC:HGNC:21044,MIM:608920 phosphatidylinositol transfer protein membrane associated 2 GO:0005509,GO:0005829,GO:0006661,GO:0008152,GO:0008289,GO:0008526,GO:0012505,GO:0016021 calcium ion binding|cytosol|phosphatidylinositol biosynthetic process|metabolic process|lipid binding|phosphatidylinositol transporter activity|endomembrane system|integral component of membrane PITPNM3 1101.12236406181 1179.70496900726 1022.53975911635 0.866775834619765 -0.20626916268352 0.170548287855772 1 4.43057 4.40625 3.75416 3.99367 GeneID:83394,Genbank:NM_001165966.1,HGNC:HGNC:21043,MIM:608921 PITPNM family member 3 GO:0005509,GO:0005829,GO:0006661,GO:0008289,GO:0008526,GO:0012505,GO:0016021,GO:0030971,GO:0046488 calcium ion binding|cytosol|phosphatidylinositol biosynthetic process|lipid binding|phosphatidylinositol transporter activity|endomembrane system|integral component of membrane|receptor tyrosine kinase binding|phosphatidylinositol metabolic process PITRM1 2186.72847675035 2166.93059790743 2206.52635559327 1.01827273920267 0.0261240317423813 0.852369906898547 1 15.9904 16.1085 16.8975 16.4116 GeneID:10531,Genbank:NM_001347726.1,HGNC:HGNC:17663 pitrilysin metallopeptidase 1 GO:0004222,GO:0005739,GO:0005759,GO:0006508,GO:0006626,GO:0008047,GO:0008237,GO:0046872 metalloendopeptidase activity|mitochondrion|mitochondrial matrix|proteolysis|protein targeting to mitochondrion|enzyme activator activity|metallopeptidase activity|metal ion binding PITX1 408.410260441735 365.135310072683 451.685210810787 1.23703514382346 0.306886487460289 0.0994365763554899 1 9.42464 9.99714 13.1369 11.7004 GeneID:5307,Genbank:NM_002653.4,HGNC:HGNC:9004,MIM:602149 paired like homeodomain 1 GO:0000978,GO:0001077,GO:0001085,GO:0001190,GO:0001501,GO:0003700,GO:0005634,GO:0005667,GO:0005730,GO:0005737,GO:0009653,GO:0014707,GO:0021983,GO:0035116,GO:0045892,GO:0048625,GO:0051216 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II transcription factor binding|skeletal system development|DNA binding transcription factor activity|nucleus|transcription factor complex|nucleolus|cytoplasm|anatomical structure morphogenesis|branchiomeric skeletal muscle development|pituitary gland development|embryonic hindlimb morphogenesis|negative regulation of transcription, DNA-templated|myoblast fate commitment|cartilage development PITX2 204.036797362913 201.617191954905 206.456402770921 1.02400197507512 0.034218497982764 0.877405361789857 1 1.87179 1.54176 1.7541 1.62102 GeneID:5308,Genbank:NM_001204399.1,HGNC:HGNC:9005,MIM:601542 paired like homeodomain 2 GO:0000122,GO:0000976,GO:0000978,GO:0000981,GO:0001077,GO:0001078,GO:0001085,GO:0001102,GO:0001105,GO:0001191,GO:0001569,GO:0001570,GO:0001701,GO:0001764,GO:0002074,GO:0003171,GO:0003253,GO:0003350,GO:0003677,GO:0003682,GO:0003700,GO:0005634,GO:0005667,GO:0005737,GO:0006355,GO:0006357,GO:0007368,GO:0007420,GO:0007507,GO:0007519,GO:0007520,GO:0008134,GO:0008584,GO:0008585,GO:0009653,GO:0009725,GO:0009887,GO:0016055,GO:0021763,GO:0021855,GO:0021983,GO:0030182,GO:0030324,GO:0030334,GO:0031076,GO:0031490,GO:0033189,GO:0035116,GO:0035886,GO:0035993,GO:0042127,GO:0042475,GO:0042476,GO:0042802,GO:0042803,GO:0043010,GO:0043388,GO:0043565,GO:0045893,GO:0045944,GO:0048536,GO:0048557,GO:0048738,GO:0051219,GO:0055007,GO:0055009,GO:0055015,GO:0055123,GO:0060412,GO:0060460,GO:0060577,GO:0060578,GO:0061031,GO:0061072,GO:0061325,GO:0070986,GO:2000288 negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription coactivator activity|transcriptional repressor activity, RNA polymerase II transcription factor binding|branching involved in blood vessel morphogenesis|vasculogenesis|in utero embryonic development|neuron migration|extraocular skeletal muscle development|atrioventricular valve development|cardiac neural crest cell migration involved in outflow tract morphogenesis|pulmonary myocardium development|DNA binding|chromatin binding|DNA binding transcription factor activity|nucleus|transcription factor complex|cytoplasm|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|determination of left/right symmetry|brain development|heart development|skeletal muscle tissue development|myoblast fusion|transcription factor binding|male gonad development|female gonad development|anatomical structure morphogenesis|response to hormone|animal organ morphogenesis|Wnt signaling pathway|subthalamic nucleus development|hypothalamus cell migration|pituitary gland development|neuron differentiation|lung development|regulation of cell migration|embryonic camera-type eye development|chromatin DNA binding|response to vitamin A|embryonic hindlimb morphogenesis|vascular smooth muscle cell differentiation|deltoid tuberosity development|regulation of cell proliferation|odontogenesis of dentin-containing tooth|odontogenesis|identical protein binding|protein homodimerization activity|camera-type eye development|positive regulation of DNA binding|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|spleen development|embryonic digestive tract morphogenesis|cardiac muscle tissue development|phosphoprotein binding|cardiac muscle cell differentiation|atrial cardiac muscle tissue morphogenesis|ventricular cardiac muscle cell development|digestive system development|ventricular septum morphogenesis|left lung morphogenesis|pulmonary vein morphogenesis|superior vena cava morphogenesis|endodermal digestive tract morphogenesis|iris morphogenesis|cell proliferation involved in outflow tract morphogenesis|left/right axis specification|positive regulation of myoblast proliferation hsa04350 TGF-beta signaling pathway PITX3 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.052168 0 0 GeneID:5309,Genbank:NM_005029.3,HGNC:HGNC:9006,MIM:602669 paired like homeodomain 3 GO:0000978,GO:0001077,GO:0002088,GO:0002089,GO:0005634,GO:0006355,GO:0007568,GO:0007626,GO:0009887,GO:0014014,GO:0030901,GO:0035902,GO:0042220,GO:0043025,GO:0043278,GO:0043525,GO:0045893,GO:0048666,GO:0070306,GO:0071542,GO:1904313,GO:1904935,GO:1990792 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|lens development in camera-type eye|lens morphogenesis in camera-type eye|nucleus|regulation of transcription, DNA-templated|aging|locomotory behavior|animal organ morphogenesis|negative regulation of gliogenesis|midbrain development|response to immobilization stress|response to cocaine|neuronal cell body|response to morphine|positive regulation of neuron apoptotic process|positive regulation of transcription, DNA-templated|neuron development|lens fiber cell differentiation|dopaminergic neuron differentiation|response to methamphetamine hydrochloride|positive regulation of cell proliferation in midbrain|cellular response to glial cell derived neurotrophic factor PIWIL2 2.02645194843327 3.084507235799 0.968396661067546 0.313955062198677 -1.67137002042877 0.55191762362676 1 0.0250835 0.0230707 0 0.00739313 GeneID:55124,Genbank:NM_018068.4,HGNC:HGNC:17644,MIM:610312 piwi like RNA-mediated gene silencing 2 GO:0000966,GO:0003729,GO:0004521,GO:0005634,GO:0005737,GO:0005844,GO:0007275,GO:0007283,GO:0010370,GO:0010529,GO:0030718,GO:0031047,GO:0033391,GO:0034584,GO:0034587,GO:0043046,GO:0043186,GO:0045727,GO:0046872,GO:0048477,GO:0051321,GO:0060903,GO:0071442,GO:0071546,GO:0097433,GO:1990511,GO:1990923,GO:2000617 RNA 5'-end processing|mRNA binding|endoribonuclease activity|nucleus|cytoplasm|polysome|multicellular organism development|spermatogenesis|perinucleolar chromocenter|negative regulation of transposition|germ-line stem cell population maintenance|gene silencing by RNA|chromatoid body|piRNA binding|piRNA metabolic process|DNA methylation involved in gamete generation|P granule|positive regulation of translation|metal ion binding|oogenesis|meiotic cell cycle|positive regulation of meiosis I|positive regulation of histone H3-K14 acetylation|pi-body|dense body|piRNA biosynthetic process|PET complex|positive regulation of histone H3-K9 acetylation PIWIL4 1.94233977400708 0.490071401957362 3.39460814605679 6.92676237074559 2.79218118163926 0.35737898201507 1 0 0.0117623 0.0481859 0.0111646 GeneID:143689,Genbank:NM_152431.2,HGNC:HGNC:18444,MIM:610315 piwi like RNA-mediated gene silencing 4 GO:0005634,GO:0005737,GO:0006417,GO:0007275,GO:0007283,GO:0010529,GO:0030154,GO:0031047,GO:0034584,GO:0034587,GO:0043046,GO:0043186,GO:0051321,GO:0071547 nucleus|cytoplasm|regulation of translation|multicellular organism development|spermatogenesis|negative regulation of transposition|cell differentiation|gene silencing by RNA|piRNA binding|piRNA metabolic process|DNA methylation involved in gamete generation|P granule|meiotic cell cycle|piP-body PJA1 743.566904555129 669.059721175381 818.074087934877 1.22272207105475 0.290096511569196 0.0693889226723539 0.918407228165493 7.86196 7.26196 9.735 8.73605 GeneID:64219,Genbank:NM_001032396.2,HGNC:HGNC:16648,MIM:300420 praja ring finger ubiquitin ligase 1 GO:0005737,GO:0030163,GO:0046872,GO:0061630 cytoplasm|protein catabolic process|metal ion binding|ubiquitin protein ligase activity PJA2 1189.92641296021 1153.63309815244 1226.21972776797 1.06292003040809 0.0880330587000634 0.6471057431885 1 8.93437 7.70222 10.1258 7.7953 GeneID:9867,Genbank:XM_017010099.2,HGNC:HGNC:17481 praja ring finger ubiquitin ligase 2 GO:0000139,GO:0004842,GO:0005737,GO:0005789,GO:0005886,GO:0007616,GO:0010738,GO:0014069,GO:0016567,GO:0030054,GO:0034236,GO:0034237,GO:0035329,GO:0045111,GO:0045211,GO:0046872,GO:0061630 Golgi membrane|ubiquitin-protein transferase activity|cytoplasm|endoplasmic reticulum membrane|plasma membrane|long-term memory|regulation of protein kinase A signaling|postsynaptic density|protein ubiquitination|cell junction|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|hippo signaling|intermediate filament cytoskeleton|postsynaptic membrane|metal ion binding|ubiquitin protein ligase activity PJVK 7.2503942501545 6.26506702096788 8.23572147934112 1.31454642891734 0.394565097898059 0.752365785380804 1 0.0482949 0.015585 0.0466215 0.144629 GeneID:494513,Genbank:XM_011511251.1,HGNC:HGNC:29502,MIM:610219 pejvakin GO:0007605,GO:0043025 sensory perception of sound|neuronal cell body PKD1 1852.60389638063 1806.87255764626 1898.335235115 1.05061932956018 0.0712400329177292 0.649034517523113 1 5.60282 6.38195 6.78759 6.10072 GeneID:5310,Genbank:XM_024450299.1,HGNC:HGNC:9008,MIM:601313 polycystin 1, transient receptor potential channel interacting PKD1L1 59.1477710340138 66.4271626012829 51.8683794667447 0.78083087453359 -0.356917995808453 0.539014875713069 1 0.206373 0.133726 0.161518 0.0953458 GeneID:168507,Genbank:XM_017011798.2,HGNC:HGNC:18053,MIM:609721 polycystin 1 like 1, transient receptor potential channel interacting GO:0003127,GO:0005262,GO:0005929,GO:0016020,GO:0034704,GO:0050982,GO:0060170,GO:0070986,GO:0097730,GO:0098609 detection of nodal flow|calcium channel activity|cilium|membrane|calcium channel complex|detection of mechanical stimulus|ciliary membrane|left/right axis specification|non-motile cilium|cell-cell adhesion PKD1L2 36.9593766697349 30.3069746813477 43.611778658122 1.43900138884409 0.525067984487882 0.265325553704321 1 0.0914697 0.0673138 0.123426 0.164071 GeneID:114780,Genbank:NM_052892.3,HGNC:HGNC:21715,MIM:607894 polycystin 1 like 2 (gene/pseudogene) GO:0005262,GO:0005509,GO:0016020,GO:0016021,GO:0030246,GO:0050982 calcium channel activity|calcium ion binding|membrane|integral component of membrane|carbohydrate binding|detection of mechanical stimulus PKD1L3 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.00525955 GeneID:342372,Genbank:XM_024450254.1,HGNC:HGNC:21716,MIM:607895 polycystin 1 like 3, transient receptor potential channel interacting GO:0001581,GO:0001822,GO:0005262,GO:0005886,GO:0006812,GO:0030246,GO:0034703,GO:0043235,GO:0050915,GO:0050982,GO:0070062,GO:0071468 detection of chemical stimulus involved in sensory perception of sour taste|kidney development|calcium channel activity|plasma membrane|cation transport|carbohydrate binding|cation channel complex|receptor complex|sensory perception of sour taste|detection of mechanical stimulus|extracellular exosome|cellular response to acidic pH hsa04742 Taste transduction PKD2 642.272452147718 570.115358256388 714.429546039047 1.25313155608371 0.325537879421689 0.109096316681505 1 3.96214 4.02171 5.8312 4.39008 GeneID:5311,Genbank:NM_000297.3,HGNC:HGNC:9009,MIM:173910 polycystin 2, transient receptor potential cation channel PKD2L1 1.75326998279533 1.56626675524197 1.94027321034868 1.23878847830677 0.308929870005269 1 1 0 0 0 0 GeneID:9033,Genbank:XM_017016875.2,HGNC:HGNC:9011,MIM:604532 polycystin 2 like 1, transient receptor potential cation channel GO:0001581,GO:0005227,GO:0005261,GO:0005262,GO:0005272,GO:0005509,GO:0005783,GO:0005886,GO:0006812,GO:0007224,GO:0008092,GO:0009986,GO:0015269,GO:0016020,GO:0016021,GO:0033040,GO:0034704,GO:0035725,GO:0042802,GO:0043231,GO:0043235,GO:0050915,GO:0050982,GO:0051371,GO:0051393,GO:0060170,GO:0070207,GO:0071468,GO:0071805,GO:0097730 detection of chemical stimulus involved in sensory perception of sour taste|calcium activated cation channel activity|cation channel activity|calcium channel activity|sodium channel activity|calcium ion binding|endoplasmic reticulum|plasma membrane|cation transport|smoothened signaling pathway|cytoskeletal protein binding|cell surface|calcium-activated potassium channel activity|membrane|integral component of membrane|sour taste receptor activity|calcium channel complex|sodium ion transmembrane transport|identical protein binding|intracellular membrane-bounded organelle|receptor complex|sensory perception of sour taste|detection of mechanical stimulus|muscle alpha-actinin binding|alpha-actinin binding|ciliary membrane|protein homotrimerization|cellular response to acidic pH|potassium ion transmembrane transport|non-motile cilium hsa04742 Taste transduction PKD2L2 10.5731082778338 15.8165550315825 5.32966152408509 0.336967279754841 -1.56931958546012 0.0837312527218215 0.963076417285947 0.0594155 0.0773042 0.0191729 0.0446742 GeneID:27039,Genbank:XM_024446028.1,HGNC:HGNC:9012,MIM:604669 polycystin 2 like 2, transient receptor potential cation channel GO:0005262,GO:0005509,GO:0016021,GO:0050982 calcium channel activity|calcium ion binding|integral component of membrane|detection of mechanical stimulus PKDCC 10.015759809289 11.3098598645963 8.72165975398169 0.771155421764634 -0.37490643888215 0.726490288142827 1 0.253588 0.197395 0.127799 0.159005 GeneID:91461,Genbank:NM_138370.2,HGNC:HGNC:25123,MIM:614150 protein kinase domain containing, cytoplasmic GO:0001501,GO:0004672,GO:0004715,GO:0005524,GO:0005576,GO:0005794,GO:0015031,GO:0018108,GO:0030154,GO:0030282,GO:0030501,GO:0032332,GO:0035108,GO:0035264,GO:0042997,GO:0048286,GO:0048566,GO:0060021 skeletal system development|protein kinase activity|non-membrane spanning protein tyrosine kinase activity|ATP binding|extracellular region|Golgi apparatus|protein transport|peptidyl-tyrosine phosphorylation|cell differentiation|bone mineralization|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|limb morphogenesis|multicellular organism growth|negative regulation of Golgi to plasma membrane protein transport|lung alveolus development|embryonic digestive tract development|palate development PKDREJ 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.00555717 0 0.00529209 GeneID:10343,Genbank:NM_006071.1,HGNC:HGNC:9015,MIM:604670 polycystin family receptor for egg jelly GO:0005262,GO:0005509,GO:0007340,GO:0016020,GO:0016021,GO:0050982 calcium channel activity|calcium ion binding|acrosome reaction|membrane|integral component of membrane|detection of mechanical stimulus PKHD1L1 1.696434100975 0 3.39286820195 Inf Inf 0.190672534648743 1 0 0 0.0047589 0.00442464 GeneID:93035,Genbank:NM_177531.5,HGNC:HGNC:20313,MIM:607843 PKHD1 like 1 GO:0004872,GO:0005615,GO:0005829,GO:0005929,GO:0006955,GO:0016021 receptor activity|extracellular space|cytosol|cilium|immune response|integral component of membrane PKIA 470.980084318584 522.252056998838 419.708111638329 0.803650471096686 -0.315359923406508 0.0789470150305553 0.945231254824065 4.9304 4.40191 4.13139 3.48115 GeneID:5569,Genbank:NM_006823.3,HGNC:HGNC:9017,MIM:606059 cAMP-dependent protein kinase inhibitor alpha GO:0000122,GO:0004862,GO:0005634,GO:0005737,GO:0010389,GO:0034236,GO:0042308,GO:2000480 negative regulation of transcription from RNA polymerase II promoter|cAMP-dependent protein kinase inhibitor activity|nucleus|cytoplasm|regulation of G2/M transition of mitotic cell cycle|protein kinase A catalytic subunit binding|negative regulation of protein import into nucleus|negative regulation of cAMP-dependent protein kinase activity hsa05034 Alcoholism PKIB 202.980709867389 198.052421972256 207.908997762522 1.04976750949123 0.0700698516599542 0.765838447750118 1 2.36239 2.20147 2.50836 2.12972 GeneID:5570,Genbank:NM_001270393.1,HGNC:HGNC:9018,MIM:606914 cAMP-dependent protein kinase inhibitor beta GO:0004862,GO:0005634,GO:0005737,GO:0032212,GO:0051973,GO:1904355,GO:2000480 cAMP-dependent protein kinase inhibitor activity|nucleus|cytoplasm|positive regulation of telomere maintenance via telomerase|positive regulation of telomerase activity|positive regulation of telomere capping|negative regulation of cAMP-dependent protein kinase activity PKIG 439.320069041505 460.447259424127 418.192878658884 0.908231876940499 -0.138867421814924 0.441414940222392 1 6.09341 6.08889 4.70676 5.80314 GeneID:11142,Genbank:NM_181805.2,HGNC:HGNC:9019,MIM:604932 cAMP-dependent protein kinase inhibitor gamma GO:0000122,GO:0004862,GO:0005634,GO:0005737,GO:0007165,GO:0042308,GO:2000480 negative regulation of transcription from RNA polymerase II promoter|cAMP-dependent protein kinase inhibitor activity|nucleus|cytoplasm|signal transduction|negative regulation of protein import into nucleus|negative regulation of cAMP-dependent protein kinase activity PKLR 2.47956747859598 1.56626675524197 3.39286820195 2.16621350775324 1.11517544580697 0.654238473929911 1 0 0.0128169 0.0407432 0.0380034 GeneID:5313,Genbank:NM_000298.5,HGNC:HGNC:9020,MIM:609712 pyruvate kinase L/R hsa00010,hsa00230,hsa00620,hsa04910,hsa04930,hsa04932,hsa04950 Glycolysis / Gluconeogenesis|Purine metabolism|Pyruvate metabolism|Insulin signaling pathway|Type II diabetes mellitus|Non-alcoholic fatty liver disease (NAFLD)|Maturity onset diabetes of the young PKM 198078.324224221 199879.632126176 196277.016322267 0.981976073471884 -0.0262402221844515 0.841744757877959 1 1707.62 1826.07 1676.29 1876.49 GeneID:5315,Genbank:NM_001206797.2,HGNC:HGNC:9021,MIM:179050 pyruvate kinase M1/2 GO:0000287,GO:0004743,GO:0005524,GO:0005634,GO:0005737,GO:0016301,GO:0030955 magnesium ion binding|pyruvate kinase activity|ATP binding|nucleus|cytoplasm|kinase activity|potassium ion binding hsa00010,hsa00230,hsa00620,hsa04922,hsa04930,hsa05165,hsa05203,hsa05230 Glycolysis / Gluconeogenesis|Purine metabolism|Pyruvate metabolism|Glucagon signaling pathway|Type II diabetes mellitus|Human papillomavirus infection|Viral carcinogenesis|Central carbon metabolism in cancer PKMYT1 992.219670061267 966.240836511971 1018.19850361056 1.05377299854781 0.0755641182646704 0.646422343608929 1 9.84369 11.1899 11.6195 11.6273 GeneID:9088,Genbank:NM_001258450.1,HGNC:HGNC:29650,MIM:602474 protein kinase, membrane associated tyrosine/threonine 1 hsa04110,hsa04114,hsa04914 Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation PKN1 4755.14104651387 4357.38091645883 5152.90117656892 1.18256844544052 0.241923687192511 0.0754481187900755 0.94157495521624 55.397 60.3649 68.7791 70.6849 GeneID:5585,Genbank:NM_002741.3,HGNC:HGNC:9405,MIM:601032 protein kinase N1 GO:0001782,GO:0001783,GO:0002634,GO:0002637,GO:0003014,GO:0003682,GO:0004672,GO:0004674,GO:0004697,GO:0005080,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005829,GO:0005886,GO:0006351,GO:0006357,GO:0006468,GO:0006469,GO:0006972,GO:0007165,GO:0007257,GO:0010631,GO:0017049,GO:0018105,GO:0030374,GO:0030496,GO:0030889,GO:0032154,GO:0035402,GO:0035407,GO:0042393,GO:0042826,GO:0043234,GO:0048365,GO:0048536,GO:0050681,GO:2000145 B cell homeostasis|B cell apoptotic process|regulation of germinal center formation|regulation of immunoglobulin production|renal system process|chromatin binding|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|protein kinase C binding|ATP binding|nucleus|nucleoplasm|cytoplasm|endosome|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|negative regulation of protein kinase activity|hyperosmotic response|signal transduction|activation of JUN kinase activity|epithelial cell migration|GTP-Rho binding|peptidyl-serine phosphorylation|ligand-dependent nuclear receptor transcription coactivator activity|midbody|negative regulation of B cell proliferation|cleavage furrow|histone kinase activity (H3-T11 specific)|histone H3-T11 phosphorylation|histone binding|histone deacetylase binding|protein complex|Rac GTPase binding|spleen development|androgen receptor binding|regulation of cell motility hsa04151,hsa05132 PI3K-Akt signaling pathway|Salmonella infection PKN2 488.268162098501 511.681191563877 464.855132633126 0.908485870298194 -0.138464018522904 0.747122466954277 1 2.96623 2.31367 3.04768 1.79854 GeneID:5586,Genbank:NM_006256.3,HGNC:HGNC:9406,MIM:602549 protein kinase N2 GO:0003723,GO:0004672,GO:0004674,GO:0004697,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0006351,GO:0006355,GO:0006468,GO:0006915,GO:0007049,GO:0007155,GO:0007165,GO:0010631,GO:0016301,GO:0016604,GO:0017049,GO:0018105,GO:0030027,GO:0030030,GO:0030496,GO:0032154,GO:0032467,GO:0035556,GO:0042826,GO:0043234,GO:0043296,GO:0043297,GO:0045070,GO:0045111,GO:0045296,GO:0045931,GO:0048471,GO:0051301,GO:0070063,GO:2000145 RNA binding|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|ATP binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|cell cycle|cell adhesion|signal transduction|epithelial cell migration|kinase activity|nuclear body|GTP-Rho binding|peptidyl-serine phosphorylation|lamellipodium|cell projection organization|midbody|cleavage furrow|positive regulation of cytokinesis|intracellular signal transduction|histone deacetylase binding|protein complex|apical junction complex|apical junction assembly|positive regulation of viral genome replication|intermediate filament cytoskeleton|cadherin binding|positive regulation of mitotic cell cycle|perinuclear region of cytoplasm|cell division|RNA polymerase binding|regulation of cell motility hsa04151,hsa05132 PI3K-Akt signaling pathway|Salmonella infection PKN3 621.827498752475 614.654020904715 629.000976600235 1.02334151442531 0.0332876885293192 0.8615540151476 1 5.52826 5.41979 5.52042 5.98135 GeneID:29941,Genbank:XM_017014650.1,HGNC:HGNC:17999,MIM:610714 protein kinase N3 GO:0004672,GO:0004674,GO:0004697,GO:0005524,GO:0005634,GO:0005794,GO:0006468,GO:0007165,GO:0010631,GO:0017049,GO:0018105,GO:0035556,GO:0048471 protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|ATP binding|nucleus|Golgi apparatus|protein phosphorylation|signal transduction|epithelial cell migration|GTP-Rho binding|peptidyl-serine phosphorylation|intracellular signal transduction|perinuclear region of cytoplasm hsa04151,hsa05132 PI3K-Akt signaling pathway|Salmonella infection PKNOX1 540.833648757551 563.120088460038 518.547209055064 0.920846582605731 -0.118967278365064 0.488939270927336 1 4.46148 4.70547 4.28982 4.26183 GeneID:5316,Genbank:NM_004571.4,HGNC:HGNC:9022,MIM:602100 PBX/knotted 1 homeobox 1 GO:0001228,GO:0001525,GO:0003700,GO:0003705,GO:0005634,GO:0005667,GO:0005737,GO:0006366,GO:0030217,GO:0030218,GO:0043010,GO:0043565,GO:0046982 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|angiogenesis|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|transcription factor complex|cytoplasm|transcription from RNA polymerase II promoter|T cell differentiation|erythrocyte differentiation|camera-type eye development|sequence-specific DNA binding|protein heterodimerization activity PKNOX2 1.96928944706134 1.02816907859967 2.91040981552302 2.83067238268525 1.5011447837805 0.664047126094342 1 0.00337819 0.00311516 0.0192229 0 GeneID:63876,Genbank:XM_024448643.1,HGNC:HGNC:16714,MIM:613066 PBX/knotted 1 homeobox 2 GO:0000977,GO:0003785,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0015629,GO:0015630,GO:0045171,GO:0051015 RNA polymerase II regulatory region sequence-specific DNA binding|actin monomer binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription from RNA polymerase II promoter|actin cytoskeleton|microtubule cytoskeleton|intercellular bridge|actin filament binding PKP2 557.901334712082 549.704847162703 566.097822261461 1.02982141267877 0.0423941729604807 0.801235659499006 1 4.5213 4.06945 5.08333 4.03775 GeneID:5318,Genbank:NM_001005242.2,HGNC:HGNC:9024,MIM:602861 plakophilin 2 GO:0001533,GO:0002159,GO:0005080,GO:0005634,GO:0005654,GO:0005882,GO:0005886,GO:0005911,GO:0005912,GO:0007507,GO:0008285,GO:0010765,GO:0014704,GO:0016021,GO:0016264,GO:0017080,GO:0019215,GO:0030054,GO:0030057,GO:0030336,GO:0031424,GO:0032947,GO:0034334,GO:0044325,GO:0045110,GO:0045294,GO:0045296,GO:0048496,GO:0055010,GO:0055088,GO:0070268,GO:0072659,GO:0086001,GO:0086002,GO:0086005,GO:0086019,GO:0086064,GO:0086073,GO:0086083,GO:0086091,GO:0098609,GO:0098911,GO:2000810 cornified envelope|desmosome assembly|protein kinase C binding|nucleus|nucleoplasm|intermediate filament|plasma membrane|cell-cell junction|adherens junction|heart development|negative regulation of cell proliferation|positive regulation of sodium ion transport|intercalated disc|integral component of membrane|gap junction assembly|sodium channel regulator activity|intermediate filament binding|cell junction|desmosome|negative regulation of cell migration|keratinization|protein complex scaffold activity|adherens junction maintenance|ion channel binding|intermediate filament bundle assembly|alpha-catenin binding|cadherin binding|maintenance of animal organ identity|ventricular cardiac muscle tissue morphogenesis|lipid homeostasis|cornification|protein localization to plasma membrane|cardiac muscle cell action potential|cardiac muscle cell action potential involved in contraction|ventricular cardiac muscle cell action potential|cell-cell signaling involved in cardiac conduction|cell communication by electrical coupling involved in cardiac conduction|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|regulation of heart rate by cardiac conduction|cell-cell adhesion|regulation of ventricular cardiac muscle cell action potential|regulation of bicellular tight junction assembly hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) PKP3 45.1243147566821 44.2210790348936 46.0275504784705 1.04085091280001 0.0577634377367922 0.956985903831668 1 0.6099 0.737923 0.53832 0.940158 GeneID:11187,Genbank:NM_001303029.1,HGNC:HGNC:9025,MIM:605561 plakophilin 3 GO:0001533,GO:0002159,GO:0005654,GO:0005886,GO:0005911,GO:0005913,GO:0010628,GO:0019899,GO:0030054,GO:0030057,GO:0031424,GO:0045294,GO:0050839,GO:0070268,GO:0072659,GO:0098641,GO:1902373,GO:1990124 cornified envelope|desmosome assembly|nucleoplasm|plasma membrane|cell-cell junction|cell-cell adherens junction|positive regulation of gene expression|enzyme binding|cell junction|desmosome|keratinization|alpha-catenin binding|cell adhesion molecule binding|cornification|protein localization to plasma membrane|cadherin binding involved in cell-cell adhesion|negative regulation of mRNA catabolic process|messenger ribonucleoprotein complex PKP4 1138.66897147524 1128.70913423923 1148.62880871125 1.01764819107755 0.0252388966688476 0.861090238745285 1 3.96157 3.66516 4.25403 3.65112 GeneID:8502,Genbank:NM_003628.4,HGNC:HGNC:9026,MIM:604276 plakophilin 4 GO:0000922,GO:0001533,GO:0005737,GO:0005856,GO:0005886,GO:0005911,GO:0007043,GO:0007267,GO:0009898,GO:0014069,GO:0030054,GO:0030057,GO:0030155,GO:0030496,GO:0031424,GO:0032467,GO:0043547,GO:0048471,GO:0051233,GO:0070268,GO:0072686,GO:0098609 spindle pole|cornified envelope|cytoplasm|cytoskeleton|plasma membrane|cell-cell junction|cell-cell junction assembly|cell-cell signaling|cytoplasmic side of plasma membrane|postsynaptic density|cell junction|desmosome|regulation of cell adhesion|midbody|keratinization|positive regulation of cytokinesis|positive regulation of GTPase activity|perinuclear region of cytoplasm|spindle midzone|cornification|mitotic spindle|cell-cell adhesion PLA2G10 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:8399,Genbank:NM_003561.2,HGNC:HGNC:9029,MIM:603603 phospholipase A2 group X GO:0004620,GO:0004623,GO:0005509,GO:0005576,GO:0005615,GO:0006654,GO:0007411,GO:0010744,GO:0010884,GO:0016042,GO:0019369,GO:0032270,GO:0032308,GO:0036148,GO:0036149,GO:0036150,GO:0036151,GO:0036152,GO:0042632,GO:0043030,GO:0043433,GO:0050482,GO:0051977,GO:0090238,GO:0090370,GO:0102567,GO:0102568,GO:1990830 phospholipase activity|phospholipase A2 activity|calcium ion binding|extracellular region|extracellular space|phosphatidic acid biosynthetic process|axon guidance|positive regulation of macrophage derived foam cell differentiation|positive regulation of lipid storage|lipid catabolic process|arachidonic acid metabolic process|positive regulation of cellular protein metabolic process|positive regulation of prostaglandin secretion|phosphatidylglycerol acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|cholesterol homeostasis|regulation of macrophage activation|negative regulation of DNA binding transcription factor activity|arachidonic acid secretion|lysophospholipid transport|positive regulation of arachidonic acid secretion|negative regulation of cholesterol efflux|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|cellular response to leukemia inhibitory factor hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04270,hsa04972,hsa04975 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Pancreatic secretion|Fat digestion and absorption PLA2G12A 632.623071149067 563.49449000241 701.751652295723 1.24535672441575 0.316559052197143 0.0545313321525408 0.850412673568737 4.65819 4.70331 6.03599 5.59813 GeneID:81579,Genbank:NM_030821.4,HGNC:HGNC:18554,MIM:611652 phospholipase A2 group XIIA GO:0004623,GO:0005509,GO:0005576,GO:0005783,GO:0005794,GO:0006654,GO:0016042,GO:0036148,GO:0036149,GO:0036150,GO:0036151,GO:0036152,GO:0047498,GO:0050482,GO:0102567,GO:0102568 phospholipase A2 activity|calcium ion binding|extracellular region|endoplasmic reticulum|Golgi apparatus|phosphatidic acid biosynthetic process|lipid catabolic process|phosphatidylglycerol acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|calcium-dependent phospholipase A2 activity|arachidonic acid secretion|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04270,hsa04972,hsa04975 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Pancreatic secretion|Fat digestion and absorption PLA2G12B 0.974269732491135 0.980142803914724 0.968396661067546 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0.0426258 GeneID:84647,Genbank:NM_001318125.1,HGNC:HGNC:18555,MIM:611653 phospholipase A2 group XIIB GO:0004623,GO:0005509,GO:0005576,GO:0006644,GO:0016042,GO:0050482 phospholipase A2 activity|calcium ion binding|extracellular region|phospholipid metabolic process|lipid catabolic process|arachidonic acid secretion hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04270,hsa04972,hsa04975 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Pancreatic secretion|Fat digestion and absorption PLA2G15 1091.82723790895 967.20136200567 1216.45311381223 1.25770409513246 0.330792533743202 0.0299341481603593 0.684893309909021 13.4537 14.12 18.8175 16.908 GeneID:23659,Genbank:NM_012320.3,HGNC:HGNC:17163,MIM:609362 phospholipase A2 group XV GO:0004622,GO:0005543,GO:0005576,GO:0005615,GO:0005654,GO:0005739,GO:0005764,GO:0006644,GO:0006650,GO:0006672,GO:0008374,GO:0009062,GO:0016020,GO:0034638,GO:0043231,GO:0046338,GO:0047499,GO:0070062 lysophospholipase activity|phospholipid binding|extracellular region|extracellular space|nucleoplasm|mitochondrion|lysosome|phospholipid metabolic process|glycerophospholipid metabolic process|ceramide metabolic process|O-acyltransferase activity|fatty acid catabolic process|membrane|phosphatidylcholine catabolic process|intracellular membrane-bounded organelle|phosphatidylethanolamine catabolic process|calcium-independent phospholipase A2 activity|extracellular exosome hsa00564,hsa04142 Glycerophospholipid metabolism|Lysosome PLA2G16 816.655242106887 823.055777247869 810.254706965904 0.984446898210509 -0.0226147066930019 0.869701906247852 1 21.6774 24.1866 21.937 23.7101 GeneID:11145,Genbank:NM_001128203.1,HGNC:HGNC:17825,MIM:613867 phospholipase A2 group XVI GO:0004623,GO:0005777,GO:0005778,GO:0005783,GO:0005829,GO:0006641,GO:0006644,GO:0007031,GO:0008654,GO:0008970,GO:0016021,GO:0016042,GO:0016746,GO:0036149,GO:0036150,GO:0036151,GO:0036152,GO:0045786,GO:0046485,GO:0048471,GO:0052739,GO:0052740,GO:0102567,GO:0102568,GO:1904177 phospholipase A2 activity|peroxisome|peroxisomal membrane|endoplasmic reticulum|cytosol|triglyceride metabolic process|phospholipid metabolic process|peroxisome organization|phospholipid biosynthetic process|phosphatidylcholine 1-acylhydrolase activity|integral component of membrane|lipid catabolic process|transferase activity, transferring acyl groups|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|negative regulation of cell cycle|ether lipid metabolic process|perinuclear region of cytoplasm|phosphatidylserine 1-acylhydrolase activity|1-acyl-2-lysophosphatidylserine acylhydrolase activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|regulation of adipose tissue development hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04923 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Regulation of lipolysis in adipocytes PLA2G1B 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:5319,Genbank:NM_000928.2,HGNC:HGNC:9030,MIM:172410 phospholipase A2 group IB hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04270,hsa04972,hsa04975 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Pancreatic secretion|Fat digestion and absorption PLA2G3 1.83237905785133 3.18055978516888 0.484198330533773 0.15223682723765 -2.71561069500597 0.389970284790734 1 0.0738347 0 0 0.0128818 GeneID:50487,Genbank:NM_015715.4,HGNC:HGNC:17934,MIM:611651 phospholipase A2 group III GO:0001675,GO:0004623,GO:0005576,GO:0005615,GO:0005814,GO:0005886,GO:0006644,GO:0007288,GO:0016042,GO:0019372,GO:0036148,GO:0036151,GO:0036152,GO:0042629,GO:0043303,GO:0046872,GO:0047498,GO:0050482,GO:0060271,GO:0102567,GO:0102568 acrosome assembly|phospholipase A2 activity|extracellular region|extracellular space|centriole|plasma membrane|phospholipid metabolic process|sperm axoneme assembly|lipid catabolic process|lipoxygenase pathway|phosphatidylglycerol acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|mast cell granule|mast cell degranulation|metal ion binding|calcium-dependent phospholipase A2 activity|arachidonic acid secretion|cilium assembly|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04270,hsa04972,hsa04975 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Pancreatic secretion|Fat digestion and absorption PLA2G4A 84.4190134526608 94.1975363785818 74.6404905267398 0.792382618445116 -0.335730860997754 0.305448862000742 1 0.896869 0.901127 0.79655 0.629347 GeneID:5321,Genbank:NM_024420.2,HGNC:HGNC:9035,MIM:600522 phospholipase A2 group IVA hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04010,hsa04014,hsa04072,hsa04217,hsa04270,hsa04370,hsa04611,hsa04664,hsa04666,hsa04724,hsa04726,hsa04730,hsa04750,hsa04912,hsa04913,hsa04921,hsa05231 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer PLA2G4B 3.58771560430505 5.23689794236822 1.93853326624189 0.370168234625792 -1.43374699685365 0.437062598875509 1 0.997297 0.0495844 0.00151429 0.243073 GeneID:100137049,Genbank:NM_001114633.1,HGNC:HGNC:9036,MIM:606088 phospholipase A2 group IVB GO:0004622,GO:0004623,GO:0005509,GO:0005544,GO:0005576,GO:0005743,GO:0005829,GO:0006644,GO:0006654,GO:0006954,GO:0007567,GO:0008970,GO:0019369,GO:0019722,GO:0031901,GO:0036148,GO:0036150,GO:0036151,GO:0036152,GO:0036498,GO:0046475,GO:0047498,GO:0102567,GO:0102568 lysophospholipase activity|phospholipase A2 activity|calcium ion binding|calcium-dependent phospholipid binding|extracellular region|mitochondrial inner membrane|cytosol|phospholipid metabolic process|phosphatidic acid biosynthetic process|inflammatory response|parturition|phosphatidylcholine 1-acylhydrolase activity|arachidonic acid metabolic process|calcium-mediated signaling|early endosome membrane|phosphatidylglycerol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|IRE1-mediated unfolded protein response|glycerophospholipid catabolic process|calcium-dependent phospholipase A2 activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04010,hsa04014,hsa04072,hsa04217,hsa04270,hsa04370,hsa04611,hsa04664,hsa04666,hsa04724,hsa04726,hsa04730,hsa04750,hsa04912,hsa04913,hsa04921,hsa05231 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer PLA2G4C 26.7050474167622 34.0256321431589 19.3844626903655 0.56970176509308 -0.811721218805022 0.145653697054044 1 0.246698 0.195021 0.135153 0.0902128 GeneID:8605,Genbank:NM_001159322.1,HGNC:HGNC:9037,MIM:603602 phospholipase A2 group IVC hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04010,hsa04014,hsa04072,hsa04217,hsa04270,hsa04370,hsa04611,hsa04664,hsa04724,hsa04726,hsa04730,hsa04750,hsa04912,hsa04913,hsa04921,hsa05231 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer PLA2G4E 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00664439 0 GeneID:123745,Genbank:NM_001206670.1,HGNC:HGNC:24791 phospholipase A2 group IVE GO:0004622,GO:0004623,GO:0005765,GO:0005829,GO:0006644,GO:0008970,GO:0009395,GO:0036149,GO:0036150,GO:0036151,GO:0036152,GO:0046872,GO:0102567,GO:0102568 lysophospholipase activity|phospholipase A2 activity|lysosomal membrane|cytosol|phospholipid metabolic process|phosphatidylcholine 1-acylhydrolase activity|phospholipid catabolic process|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|metal ion binding|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04010,hsa04014,hsa04072,hsa04217,hsa04270,hsa04370,hsa04611,hsa04664,hsa04666,hsa04724,hsa04726,hsa04730,hsa04750,hsa04912,hsa04913,hsa04921,hsa05231 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer PLA2G4F 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0111577 0 GeneID:255189,Genbank:NM_213600.3,HGNC:HGNC:27396 phospholipase A2 group IVF GO:0001516,GO:0004622,GO:0004623,GO:0005765,GO:0005829,GO:0006644,GO:0008970,GO:0009395,GO:0031982,GO:0032587,GO:0036148,GO:0036149,GO:0036150,GO:0036151,GO:0036152,GO:0046872,GO:0047498,GO:0050482,GO:0071236,GO:0071407,GO:0102567,GO:0102568 prostaglandin biosynthetic process|lysophospholipase activity|phospholipase A2 activity|lysosomal membrane|cytosol|phospholipid metabolic process|phosphatidylcholine 1-acylhydrolase activity|phospholipid catabolic process|vesicle|ruffle membrane|phosphatidylglycerol acyl-chain remodeling|phosphatidylinositol acyl-chain remodeling|phosphatidylserine acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|metal ion binding|calcium-dependent phospholipase A2 activity|arachidonic acid secretion|cellular response to antibiotic|cellular response to organic cyclic compound|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04010,hsa04014,hsa04072,hsa04217,hsa04270,hsa04370,hsa04611,hsa04664,hsa04666,hsa04724,hsa04726,hsa04730,hsa04750,hsa04912,hsa04913,hsa04921,hsa05231 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|MAPK signaling pathway|Ras signaling pathway|Phospholipase D signaling pathway|Necroptosis|Vascular smooth muscle contraction|VEGF signaling pathway|Platelet activation|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|Serotonergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Ovarian steroidogenesis|Oxytocin signaling pathway|Choline metabolism in cancer PLA2G5 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0205277 GeneID:5322,Genbank:XM_011541589.3,HGNC:HGNC:9038,MIM:601192 phospholipase A2 group V hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04270,hsa04972,hsa04975 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Pancreatic secretion|Fat digestion and absorption PLA2G6 113.951417611724 110.619832671707 117.283002551741 1.06023485770231 0.0843838784789951 0.804213415086657 1 0.526954 0.556586 0.618673 0.570541 GeneID:8398,Genbank:XM_006724332.4,HGNC:HGNC:9039,MIM:603604 phospholipase A2 group VI hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04014,hsa04270,hsa04666,hsa04750 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Ras signaling pathway|Vascular smooth muscle contraction|Fc gamma R-mediated phagocytosis|Inflammatory mediator regulation of TRP channels PLA2G7 1.75283499676863 1.56626675524197 1.93940323829528 1.23823303521223 0.308282855026159 1 1 0.023875 0.0116609 0.0347419 0.0107626 GeneID:7941,Genbank:XM_005249408.4,HGNC:HGNC:9040,MIM:601690 phospholipase A2 group VII hsa00565 Ether lipid metabolism PLA2R1 5.37466539743682 3.47852608838648 7.27080470648717 2.09019697473643 1.06363890454782 0.465743887814709 1 0 0.0282495 0.0235875 0.0262708 GeneID:22925,Genbank:XM_011510820.3,HGNC:HGNC:9042,MIM:604939 phospholipase A2 receptor 1 hsa04145,hsa05152 Phagosome|Tuberculosis PLAA 1094.72232047548 1140.64333567473 1048.80130527622 0.919482253982421 -0.121106364011558 0.431634360118924 1 6.1081 5.95809 6.14775 4.94765 GeneID:9373,Genbank:NM_001031689.2,HGNC:HGNC:9043,MIM:603873 phospholipase A2 activating protein GO:0005634,GO:0005737,GO:0006644,GO:0006693,GO:0006954,GO:0007165,GO:0010992,GO:0016005,GO:0016236,GO:0030054,GO:0032430,GO:0043130,GO:0043161,GO:0043162,GO:0045202,GO:0070062,GO:0071222,GO:1900045,GO:1903423,GO:1903861,GO:2001224 nucleus|cytoplasm|phospholipid metabolic process|prostaglandin metabolic process|inflammatory response|signal transduction|ubiquitin recycling|phospholipase A2 activator activity|macroautophagy|cell junction|positive regulation of phospholipase A2 activity|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|synapse|extracellular exosome|cellular response to lipopolysaccharide|negative regulation of protein K63-linked ubiquitination|positive regulation of synaptic vesicle recycling|positive regulation of dendrite extension|positive regulation of neuron migration hsa04141 Protein processing in endoplasmic reticulum PLAC1 5.82300898750066 6.80316469761019 4.84285327739113 0.711853011451027 -0.490348721031319 0.788277721781101 1 0.15298 0.0927331 0.0240651 0.179576 GeneID:10761,Genbank:XM_011531257.2,HGNC:HGNC:9044,MIM:300296 placenta specific 1 GO:0001890,GO:0005576 placenta development|extracellular region PLAC8 79.9459008443212 82.8494588944085 77.0423427942339 0.929907615841212 -0.104840699944282 0.755281307204314 1 0.918393 0.792264 0.523664 0.563842 GeneID:51316,Genbank:NM_016619.2,HGNC:HGNC:19254,MIM:607515 placenta specific 8 GO:0003682,GO:0005576,GO:0008284,GO:0009409,GO:0035578,GO:0040015,GO:0042742,GO:0043066,GO:0043312,GO:0045944,GO:0050873 chromatin binding|extracellular region|positive regulation of cell proliferation|response to cold|azurophil granule lumen|negative regulation of multicellular organism growth|defense response to bacterium|negative regulation of apoptotic process|neutrophil degranulation|positive regulation of transcription from RNA polymerase II promoter|brown fat cell differentiation PLAC8L1 4.71660080589839 3.13253351048394 6.30066810131283 2.0113649479649 1.0081748722204 0.500230706154403 1 0.0154474 0.0294737 0.0743073 0.0554187 GeneID:153770,Genbank:XM_005268381.3,HGNC:HGNC:31746 PLAC8 like 1 PLAG1 31.1266280498136 35.5918988984008 26.6613572012264 0.749084989180623 -0.416798682593921 0.433285258426861 1 0.209775 0.191289 0.196899 0.105538 GeneID:5324,Genbank:NM_001114635.1,HGNC:HGNC:9045,MIM:603026 PLAG1 zinc finger PLAGL1 540.516646876819 502.322825652857 578.710468100781 1.15206882615506 0.204226907914357 0.298290950634314 1 3.59099 3.29059 4.63885 3.50992 GeneID:5325,Genbank:NM_001289038.1,HGNC:HGNC:9046,MIM:603044 PLAG1 like zinc finger 1 PLAGL2 744.729419376642 785.772133079533 703.686705673751 0.89553532894571 -0.159177747110075 0.315728742830766 1 4.6909 5.00336 4.54365 4.23962 GeneID:5326,Genbank:NM_002657.3,HGNC:HGNC:9047,MIM:604866 PLAG1 like zinc finger 2 PLAT 4468.43940654054 4183.22327232033 4753.65554076075 1.13636189878147 0.184422365150702 0.173803469238496 1 47.0294 50.4079 55.9025 55.6926 GeneID:5327,Genbank:NM_033011.3,HGNC:HGNC:9051,MIM:173370 plasminogen activator, tissue type hsa04371,hsa04610,hsa05202,hsa05215,hsa05418 Apelin signaling pathway|Complement and coagulation cascades|Transcriptional misregulation in cancer|Prostate cancer|Fluid shear stress and atherosclerosis PLAU 13858.3854733818 15399.8103037673 12316.9606429963 0.799812491195631 -0.322266282049812 0.0124740983429519 0.457174277026815 200.143 202.797 154.425 172.051 GeneID:5328,Genbank:XM_011539866.2,HGNC:HGNC:9052,MIM:191840 plasminogen activator, urokinase hsa04064,hsa04610,hsa05202,hsa05205,hsa05206,hsa05215 NF-kappa B signaling pathway|Complement and coagulation cascades|Transcriptional misregulation in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Prostate cancer PLAUR 1589.82468321945 1749.96542308856 1429.68394335035 0.816978395394274 -0.291630167397261 0.0411726087907459 0.759435523043776 8.31902 7.92414 7.36252 6.3732 GeneID:5329,Genbank:NM_001005376.2,HGNC:HGNC:9053,MIM:173391 plasminogen activator, urokinase receptor hsa04610,hsa05205 Complement and coagulation cascades|Proteoglycans in cancer PLB1 79.0070139390985 68.3590392446433 89.6549886335537 1.31153084689644 0.391251739849306 0.247862607547946 1 0.12967 0.152842 0.195293 0.182345 GeneID:151056,Genbank:XM_011532606.3,HGNC:HGNC:30041,MIM:610179 phospholipase B1 GO:0001523,GO:0004622,GO:0004623,GO:0005886,GO:0016021,GO:0016042,GO:0016324,GO:0036151,GO:0050253,GO:0102567,GO:0102568,GO:2000344 retinoid metabolic process|lysophospholipase activity|phospholipase A2 activity|plasma membrane|integral component of membrane|lipid catabolic process|apical plasma membrane|phosphatidylcholine acyl-chain remodeling|retinyl-palmitate esterase activity|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)|positive regulation of acrosome reaction hsa00564,hsa00565,hsa00590,hsa00591,hsa00592,hsa04977 Glycerophospholipid metabolism|Ether lipid metabolism|Arachidonic acid metabolism|Linoleic acid metabolism|alpha-Linolenic acid metabolism|Vitamin digestion and absorption PLBD1 21.9132170029996 21.0534529739507 22.7729810320485 1.08167439612995 0.113266286796178 0.887607919195225 1 0.385761 0.378655 0.251936 0.376869 GeneID:79887,Genbank:NM_024829.5,HGNC:HGNC:26215 phospholipase B domain containing 1 GO:0004622,GO:0004623,GO:0005615,GO:0005764,GO:0005829,GO:0006644,GO:0016042,GO:0036149,GO:0036151,GO:0036152 lysophospholipase activity|phospholipase A2 activity|extracellular space|lysosome|cytosol|phospholipid metabolic process|lipid catabolic process|phosphatidylinositol acyl-chain remodeling|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling PLBD2 1670.66018572176 1635.84744701825 1705.47292442526 1.04256232910589 0.0601336371029774 0.678300757316245 1 11.8268 11.6406 13.1909 11.5431 GeneID:196463,Genbank:NM_173542.3,HGNC:HGNC:27283 phospholipase B domain containing 2 GO:0016042,GO:0016787,GO:0043202,GO:0070062 lipid catabolic process|hydrolase activity|lysosomal lumen|extracellular exosome PLCB1 96.6093504012103 84.6460483679672 108.572652434453 1.2826665216842 0.359146135315988 0.229477764577875 1 0.38951 0.331157 0.568633 0.339302 GeneID:23236,Genbank:NM_182734.2,HGNC:HGNC:15917,MIM:607120 phospholipase C beta 1 hsa00562,hsa04015,hsa04020,hsa04022,hsa04062,hsa04070,hsa04071,hsa04072,hsa04261,hsa04270,hsa04310,hsa04371,hsa04540,hsa04611,hsa04621,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04933,hsa04934,hsa04961,hsa04970,hsa04971,hsa04972,hsa05010,hsa05016,hsa05142,hsa05143,hsa05146,hsa05163,hsa05200 Inositol phosphate metabolism|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Huntington disease|Chagas disease (American trypanosomiasis)|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Pathways in cancer PLCB3 1125.9253012383 1086.80515904603 1165.04544343057 1.07199108665736 0.100292910190567 0.515215280283955 1 6.52373 6.63284 7.47325 7.04873 GeneID:5331,Genbank:NM_000932.2,HGNC:HGNC:9056,MIM:600230 phospholipase C beta 3 GO:0003073,GO:0004435,GO:0004629,GO:0004871,GO:0005509,GO:0005516,GO:0005654,GO:0005829,GO:0007186,GO:0007223,GO:0016020,GO:0016042,GO:0035556,GO:0043234,GO:0043647,GO:0045296 regulation of systemic arterial blood pressure|phosphatidylinositol phospholipase C activity|phospholipase C activity|signal transducer activity|calcium ion binding|calmodulin binding|nucleoplasm|cytosol|G-protein coupled receptor signaling pathway|Wnt signaling pathway, calcium modulating pathway|membrane|lipid catabolic process|intracellular signal transduction|protein complex|inositol phosphate metabolic process|cadherin binding hsa00562,hsa04015,hsa04020,hsa04022,hsa04062,hsa04070,hsa04071,hsa04072,hsa04261,hsa04270,hsa04310,hsa04371,hsa04540,hsa04611,hsa04621,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04933,hsa04934,hsa04961,hsa04970,hsa04971,hsa04972,hsa05010,hsa05016,hsa05142,hsa05143,hsa05146,hsa05163,hsa05200 Inositol phosphate metabolism|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Huntington disease|Chagas disease (American trypanosomiasis)|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Pathways in cancer PLCB4 14.1160238355425 11.7519049918688 16.4801426792162 1.40233797759759 0.487834095312273 0.552065622262002 1 0.0289347 0.0275827 0.0660489 0.0258599 GeneID:5332,Genbank:XM_017027880.1,HGNC:HGNC:9059,MIM:600810 phospholipase C beta 4 GO:0004435,GO:0004629,GO:0004871,GO:0005509,GO:0005634,GO:0005790,GO:0005829,GO:0007186,GO:0014069,GO:0016042,GO:0030425,GO:0035556,GO:0043647 phosphatidylinositol phospholipase C activity|phospholipase C activity|signal transducer activity|calcium ion binding|nucleus|smooth endoplasmic reticulum|cytosol|G-protein coupled receptor signaling pathway|postsynaptic density|lipid catabolic process|dendrite|intracellular signal transduction|inositol phosphate metabolic process hsa00562,hsa04015,hsa04020,hsa04022,hsa04062,hsa04070,hsa04071,hsa04072,hsa04261,hsa04270,hsa04310,hsa04371,hsa04540,hsa04611,hsa04621,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04933,hsa04934,hsa04961,hsa04970,hsa04971,hsa04972,hsa05010,hsa05016,hsa05142,hsa05143,hsa05146,hsa05163,hsa05200 Inositol phosphate metabolism|Rap1 signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Chemokine signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Apelin signaling pathway|Gap junction|Platelet activation|NOD-like receptor signaling pathway|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|AGE-RAGE signaling pathway in diabetic complications|Cushing syndrome|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Alzheimer disease|Huntington disease|Chagas disease (American trypanosomiasis)|African trypanosomiasis|Amoebiasis|Human cytomegalovirus infection|Pathways in cancer PLCD1 181.631282403043 160.212079817916 203.05048498817 1.26738561298836 0.341855543661482 0.152050302462916 1 1.60263 1.51449 2.0263 2.17572 GeneID:5333,Genbank:NM_006225.3,HGNC:HGNC:9060,MIM:602142 phospholipase C delta 1 hsa00562,hsa04020,hsa04070,hsa04919,hsa04933 Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications PLCD3 1575.65431564418 1355.7826471323 1795.52598415606 1.32434648573936 0.405280620530221 0.00526128156944569 0.285941071095182 13.1527 13.2094 18.4191 17.7103 GeneID:113026,Genbank:NM_133373.4,HGNC:HGNC:9061,MIM:608795 phospholipase C delta 3 GO:0001525,GO:0004435,GO:0004871,GO:0005829,GO:0005886,GO:0016042,GO:0032154,GO:0035556,GO:0042127,GO:0043647,GO:0046872,GO:0060716 angiogenesis|phosphatidylinositol phospholipase C activity|signal transducer activity|cytosol|plasma membrane|lipid catabolic process|cleavage furrow|intracellular signal transduction|regulation of cell proliferation|inositol phosphate metabolic process|metal ion binding|labyrinthine layer blood vessel development hsa00562,hsa04020,hsa04070,hsa04919,hsa04933 Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications PLCD4 144.00941680195 136.314250981591 151.704582622309 1.11290332103865 0.154328269844087 0.560669782981899 1 0.673845 0.763525 0.875873 0.74551 GeneID:84812,Genbank:XM_017005118.2,HGNC:HGNC:9062,MIM:605939 phospholipase C delta 4 GO:0004435,GO:0004871,GO:0005509,GO:0005789,GO:0005829,GO:0005886,GO:0007340,GO:0016042,GO:0031965,GO:0035556,GO:0043647,GO:0046488 phosphatidylinositol phospholipase C activity|signal transducer activity|calcium ion binding|endoplasmic reticulum membrane|cytosol|plasma membrane|acrosome reaction|lipid catabolic process|nuclear membrane|intracellular signal transduction|inositol phosphate metabolic process|phosphatidylinositol metabolic process hsa00562,hsa04020,hsa04070,hsa04919,hsa04933 Inositol phosphate metabolism|Calcium signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications PLCE1 625.62922508578 554.701613731647 696.556836439914 1.25573248607294 0.328529153622593 0.377083221825456 1 1.36596 1.16966 2.02417 1.24935 GeneID:51196,Genbank:NM_016341.3,HGNC:HGNC:17175,MIM:608414 phospholipase C epsilon 1 GO:0000139,GO:0000187,GO:0001558,GO:0004435,GO:0004629,GO:0005057,GO:0005085,GO:0005829,GO:0005886,GO:0006644,GO:0006651,GO:0006940,GO:0007010,GO:0007173,GO:0007200,GO:0007204,GO:0007205,GO:0007265,GO:0007507,GO:0008277,GO:0008283,GO:0016042,GO:0017016,GO:0019722,GO:0019899,GO:0032835,GO:0043647,GO:0045859,GO:0046578,GO:0046872,GO:0048016 Golgi membrane|activation of MAPK activity|regulation of cell growth|phosphatidylinositol phospholipase C activity|phospholipase C activity|signal transducer activity, downstream of receptor|guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|phospholipid metabolic process|diacylglycerol biosynthetic process|regulation of smooth muscle contraction|cytoskeleton organization|epidermal growth factor receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|protein kinase C-activating G-protein coupled receptor signaling pathway|Ras protein signal transduction|heart development|regulation of G-protein coupled receptor protein signaling pathway|cell proliferation|lipid catabolic process|Ras GTPase binding|calcium-mediated signaling|enzyme binding|glomerulus development|inositol phosphate metabolic process|regulation of protein kinase activity|regulation of Ras protein signal transduction|metal ion binding|inositol phosphate-mediated signaling hsa00562,hsa04014,hsa04015,hsa04020,hsa04024,hsa04070,hsa04919,hsa04933,hsa05205 Inositol phosphate metabolism|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Phosphatidylinositol signaling system|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Proteoglycans in cancer PLCG1 2942.85968385919 2784.06440178725 3101.65496593112 1.11407443159001 0.1558456227126 0.25843863319069 1 15.9591 16.1346 18.925 17.4752 GeneID:5335,Genbank:XM_005260438.2,HGNC:HGNC:9065,MIM:172420 phospholipase C gamma 1 hsa00562,hsa01521,hsa04012,hsa04014,hsa04015,hsa04020,hsa04064,hsa04066,hsa04070,hsa04072,hsa04360,hsa04370,hsa04650,hsa04658,hsa04659,hsa04660,hsa04664,hsa04666,hsa04670,hsa04722,hsa04750,hsa04919,hsa04933,hsa05110,hsa05120,hsa05167,hsa05170,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225,hsa05231 Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Axon guidance|VEGF signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma|Choline metabolism in cancer PLCG2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00432418 0 GeneID:5336,Genbank:NM_002661.4,HGNC:HGNC:9066,MIM:600220 phospholipase C gamma 2 GO:0001784,GO:0002092,GO:0002223,GO:0002316,GO:0004435,GO:0004629,GO:0004871,GO:0005829,GO:0005886,GO:0006661,GO:0009395,GO:0010468,GO:0016055,GO:0019722,GO:0030168,GO:0030183,GO:0032237,GO:0032481,GO:0032496,GO:0032959,GO:0038095,GO:0038096,GO:0043069,GO:0043647,GO:0050852,GO:0050853,GO:0051209,GO:0070062 phosphotyrosine residue binding|positive regulation of receptor internalization|stimulatory C-type lectin receptor signaling pathway|follicular B cell differentiation|phosphatidylinositol phospholipase C activity|phospholipase C activity|signal transducer activity|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|phospholipid catabolic process|regulation of gene expression|Wnt signaling pathway|calcium-mediated signaling|platelet activation|B cell differentiation|activation of store-operated calcium channel activity|positive regulation of type I interferon production|response to lipopolysaccharide|inositol trisphosphate biosynthetic process|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|negative regulation of programmed cell death|inositol phosphate metabolic process|T cell receptor signaling pathway|B cell receptor signaling pathway|release of sequestered calcium ion into cytosol|extracellular exosome hsa00562,hsa01521,hsa04012,hsa04014,hsa04020,hsa04064,hsa04066,hsa04070,hsa04072,hsa04360,hsa04370,hsa04380,hsa04611,hsa04625,hsa04650,hsa04662,hsa04664,hsa04666,hsa04670,hsa04722,hsa04750,hsa04919,hsa04933,hsa05110,hsa05120,hsa05167,hsa05169,hsa05170,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225 Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|ErbB signaling pathway|Ras signaling pathway|Calcium signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Phospholipase D signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Platelet activation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma PLCH1 153.252507544442 124.274188341613 182.230826747271 1.46636102942265 0.552240349879022 0.0293967683696663 0.679391980098955 0.262694 0.320077 0.477905 0.367584 GeneID:23007,Genbank:XM_017005927.1,HGNC:HGNC:29185,MIM:612835 phospholipase C eta 1 GO:0004435,GO:0004871,GO:0005509,GO:0005737,GO:0005829,GO:0005886,GO:0016042,GO:0043231,GO:0043647,GO:0048015,GO:0050429 phosphatidylinositol phospholipase C activity|signal transducer activity|calcium ion binding|cytoplasm|cytosol|plasma membrane|lipid catabolic process|intracellular membrane-bounded organelle|inositol phosphate metabolic process|phosphatidylinositol-mediated signaling|calcium-dependent phospholipase C activity hsa00562 Inositol phosphate metabolism PLCH2 12.2090083556984 13.2701454724258 11.1478712389709 0.840071517085872 -0.251415942051741 0.795645910664115 1 0 0 0.00571442 0 GeneID:9651,Genbank:XM_024451062.1,HGNC:HGNC:29037,MIM:612836 phospholipase C eta 2 GO:0004435,GO:0004871,GO:0005509,GO:0005737,GO:0005886,GO:0016042,GO:0035556,GO:0043647,GO:0046488 phosphatidylinositol phospholipase C activity|signal transducer activity|calcium ion binding|cytoplasm|plasma membrane|lipid catabolic process|intracellular signal transduction|inositol phosphate metabolic process|phosphatidylinositol metabolic process hsa00562 Inositol phosphate metabolism PLCL1 8.47056965567772 7.73528122683997 9.20585808451546 1.1901129143919 0.251098458663647 0.852485098185778 1 0.0450799 0.0323889 0.0380166 0.0606128 GeneID:5334,Genbank:NM_006226.3,HGNC:HGNC:9063,MIM:600597 phospholipase C like 1 (inactive) GO:0004435,GO:0004629,GO:0004871,GO:0005737,GO:0005886,GO:0006629,GO:0007214,GO:0032228,GO:0033135,GO:0035556,GO:0050811,GO:0070679,GO:1900122 phosphatidylinositol phospholipase C activity|phospholipase C activity|signal transducer activity|cytoplasm|plasma membrane|lipid metabolic process|gamma-aminobutyric acid signaling pathway|regulation of synaptic transmission, GABAergic|regulation of peptidyl-serine phosphorylation|intracellular signal transduction|GABA receptor binding|inositol 1,4,5 trisphosphate binding|positive regulation of receptor binding hsa04727 GABAergic synapse PLCL2 216.36326238565 190.383767329462 242.342757441838 1.27291712335149 0.348138491806392 0.239543327966731 1 0.65963 0.496762 0.854795 0.639586 GeneID:23228,Genbank:XM_017006023.1,HGNC:HGNC:9064,MIM:614276 phospholipase C like 2 GO:0002322,GO:0002337,GO:0004435,GO:0004871,GO:0005737,GO:0006629,GO:0007214,GO:0032228,GO:0033135,GO:0035556,GO:0050811,GO:0050859,GO:0070679,GO:1900122 B cell proliferation involved in immune response|B-1a B cell differentiation|phosphatidylinositol phospholipase C activity|signal transducer activity|cytoplasm|lipid metabolic process|gamma-aminobutyric acid signaling pathway|regulation of synaptic transmission, GABAergic|regulation of peptidyl-serine phosphorylation|intracellular signal transduction|GABA receptor binding|negative regulation of B cell receptor signaling pathway|inositol 1,4,5 trisphosphate binding|positive regulation of receptor binding PLCXD1 7.65365769590406 8.52331893201493 6.7839964597932 0.795933663154554 -0.329279900080807 0.782796483079561 1 0.00930041 0.0903656 0.0521034 0.0486463 GeneID:55344,Genbank:XM_006724446.3,HGNC:HGNC:23148,MIM:300974 phosphatidylinositol specific phospholipase C X domain containing 1 GO:0005737,GO:0006629,GO:0008081 cytoplasm|lipid metabolic process|phosphoric diester hydrolase activity PLCXD2 2.02732192048667 3.084507235799 0.97013660517434 0.314519153631695 -1.66878021766181 0.551855804198651 1 0.0559615 0.0506042 0.035164 0 GeneID:257068,Genbank:NM_001185106.1,HGNC:HGNC:26462,MIM:617015 phosphatidylinositol specific phospholipase C X domain containing 2 GO:0004871,GO:0005634,GO:0008081,GO:0016042 signal transducer activity|nucleus|phosphoric diester hydrolase activity|lipid catabolic process PLCXD3 79.0492773002446 71.3278766208565 86.7706779796326 1.21650443123188 0.282741575438374 0.559651057558242 1 0.341406 0.26813 0.492086 0.263455 GeneID:345557,Genbank:NM_001005473.2,HGNC:HGNC:31822,MIM:617016 phosphatidylinositol specific phospholipase C X domain containing 3 GO:0004871,GO:0005737,GO:0008081,GO:0016042 signal transducer activity|cytoplasm|phosphoric diester hydrolase activity|lipid catabolic process PLD1 227.516085368931 228.205509174441 226.826661563422 0.993957868870006 -0.00874339366367373 0.989674841998415 1 0.923394 0.886309 1.06877 0.837632 GeneID:5337,Genbank:XM_005247534.2,HGNC:HGNC:9067,MIM:602382 phospholipase D1 hsa00564,hsa00565,hsa04014,hsa04024,hsa04071,hsa04072,hsa04144,hsa04666,hsa04724,hsa04912,hsa04928,hsa05200,hsa05212,hsa05231 Glycerophospholipid metabolism|Ether lipid metabolism|Ras signaling pathway|cAMP signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Pancreatic cancer|Choline metabolism in cancer PLD2 584.011574688685 543.82500734007 624.1981420373 1.14779227437581 0.198861568978338 0.238025621801137 1 5.23047 4.97115 6.20064 6.12778 GeneID:5338,Genbank:NM_002663.4,HGNC:HGNC:9068,MIM:602384 phospholipase D2 hsa00564,hsa00565,hsa04014,hsa04024,hsa04071,hsa04072,hsa04144,hsa04666,hsa04724,hsa04912,hsa04928,hsa05231 Glycerophospholipid metabolism|Ether lipid metabolism|Ras signaling pathway|cAMP signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Endocytosis|Fc gamma R-mediated phagocytosis|Glutamatergic synapse|GnRH signaling pathway|Parathyroid hormone synthesis, secretion and action|Choline metabolism in cancer PLD3 2334.40902866079 2045.15682685199 2623.66123046958 1.28286554655471 0.359369973636176 0.0103361799370938 0.408751254006157 28.9625 30.5645 37.596 39.2373 GeneID:23646,Genbank:XM_017026546.1,HGNC:HGNC:17158,MIM:615698 phospholipase D family member 3 GO:0004630,GO:0005789,GO:0016021,GO:0016042,GO:0070062,GO:0070290 phospholipase D activity|endoplasmic reticulum membrane|integral component of membrane|lipid catabolic process|extracellular exosome|N-acylphosphatidylethanolamine-specific phospholipase D activity hsa00564,hsa00565 Glycerophospholipid metabolism|Ether lipid metabolism PLD4 4.72954354035056 5.58289052027075 3.87619656043037 0.694299224811306 -0.526370534224413 0.757832364978151 1 0.0333814 0.0580594 0.0154565 0.0433943 GeneID:122618,Genbank:XM_024449469.1,HGNC:HGNC:23792 phospholipase D family member 4 GO:0004435,GO:0004630,GO:0005789,GO:0016021,GO:0016042,GO:0043647,GO:0070290 phosphatidylinositol phospholipase C activity|phospholipase D activity|endoplasmic reticulum membrane|integral component of membrane|lipid catabolic process|inositol phosphate metabolic process|N-acylphosphatidylethanolamine-specific phospholipase D activity hsa00564,hsa00565 Glycerophospholipid metabolism|Ether lipid metabolism PLD5 29.5667423114486 24.7240841610769 34.4094004618202 1.3917360998144 0.476885674129574 0.364766697837971 1 0.0722857 0.0690039 0.104055 0.0808142 GeneID:200150,Genbank:XM_011544120.2,HGNC:HGNC:26879 phospholipase D family member 5 GO:0003824,GO:0016021 catalytic activity|integral component of membrane PLD6 192.683790633719 198.312170655897 187.055410611541 0.943237169926963 -0.0843075235027919 0.70713506596641 1 3.68086 4.13195 3.54657 3.78707 GeneID:201164,Genbank:XM_017024310.2,HGNC:HGNC:30447,MIM:614960 phospholipase D family member 6 GO:0004519,GO:0005741,GO:0006654,GO:0007286,GO:0008053,GO:0010636,GO:0016021,GO:0016042,GO:0030719,GO:0034587,GO:0035755,GO:0042803,GO:0043046,GO:0046872,GO:0051321 endonuclease activity|mitochondrial outer membrane|phosphatidic acid biosynthetic process|spermatid development|mitochondrial fusion|positive regulation of mitochondrial fusion|integral component of membrane|lipid catabolic process|P granule organization|piRNA metabolic process|cardiolipin hydrolase activity|protein homodimerization activity|DNA methylation involved in gamete generation|metal ion binding|meiotic cell cycle PLEC 14683.0954846283 14439.5714402962 14926.6195289604 1.03373009307638 0.0478595471508262 0.741109673662126 1 37.0646 39.5095 43.1988 38.1492 GeneID:5339,Genbank:NM_000445.4,HGNC:HGNC:9069,MIM:601282 plectin PLEK 1.75240001074193 1.56626675524197 1.93853326624189 1.2376775921177 0.307635549745768 1 1 0.026876 0.0125919 0.0256501 0.0239353 GeneID:5341,Genbank:NM_002664.2,HGNC:HGNC:9070,MIM:173570 pleckstrin GO:0002244,GO:0002576,GO:0005080,GO:0005576,GO:0005737,GO:0005829,GO:0006904,GO:0007229,GO:0010572,GO:0010920,GO:0010925,GO:0016020,GO:0030030,GO:0030836,GO:0030845,GO:0030866,GO:0031529,GO:0031532,GO:0032233,GO:0032587,GO:0033625,GO:0042803,GO:0043325,GO:0045744,GO:0046488,GO:0050849,GO:0060305,GO:0070493,GO:0070527,GO:0070528,GO:0070560 hematopoietic progenitor cell differentiation|platelet degranulation|protein kinase C binding|extracellular region|cytoplasm|cytosol|vesicle docking involved in exocytosis|integrin-mediated signaling pathway|positive regulation of platelet activation|negative regulation of inositol phosphate biosynthetic process|positive regulation of inositol-polyphosphate 5-phosphatase activity|membrane|cell projection organization|positive regulation of actin filament depolymerization|phospholipase C-inhibiting G-protein coupled receptor signaling pathway|cortical actin cytoskeleton organization|ruffle organization|actin cytoskeleton reorganization|positive regulation of actin filament bundle assembly|ruffle membrane|positive regulation of integrin activation|protein homodimerization activity|phosphatidylinositol-3,4-bisphosphate binding|negative regulation of G-protein coupled receptor protein signaling pathway|phosphatidylinositol metabolic process|negative regulation of calcium-mediated signaling|regulation of cell diameter|thrombin-activated receptor signaling pathway|platelet aggregation|protein kinase C signaling|protein secretion by platelet PLEKHA1 261.727886799842 275.789444438135 247.666329161549 0.898026861274979 -0.155169496191959 0.473940310071303 1 1.86565 1.72656 1.85102 1.44318 GeneID:59338,Genbank:NM_001330178.1,HGNC:HGNC:14335,MIM:607772 pleckstrin homology domain containing A1 GO:0001553,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006661,GO:0007283,GO:0008209,GO:0008210,GO:0009791,GO:0014065,GO:0030165,GO:0031529,GO:0032587,GO:0033327,GO:0035264,GO:0043325,GO:0045184,GO:0048008,GO:0048705,GO:0050853,GO:0051898,GO:0060021,GO:0060325,GO:0070062,GO:0070301 luteinization|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|spermatogenesis|androgen metabolic process|estrogen metabolic process|post-embryonic development|phosphatidylinositol 3-kinase signaling|PDZ domain binding|ruffle organization|ruffle membrane|Leydig cell differentiation|multicellular organism growth|phosphatidylinositol-3,4-bisphosphate binding|establishment of protein localization|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|B cell receptor signaling pathway|negative regulation of protein kinase B signaling|palate development|face morphogenesis|extracellular exosome|cellular response to hydrogen peroxide PLEKHA2 2231.58260442782 1945.00875606331 2518.15645279232 1.2946761524555 0.372591270363225 0.00734705612720608 0.340518730665856 13.6382 13.6137 18.4959 17.0096 GeneID:59339,Genbank:NM_021623.1,HGNC:HGNC:14336,MIM:607773 pleckstrin homology domain containing A2 GO:0001954,GO:0001968,GO:0005634,GO:0005737,GO:0005886,GO:0006661,GO:0016020,GO:0030165,GO:0035091,GO:0043234,GO:0043236,GO:0043325 positive regulation of cell-matrix adhesion|fibronectin binding|nucleus|cytoplasm|plasma membrane|phosphatidylinositol biosynthetic process|membrane|PDZ domain binding|phosphatidylinositol binding|protein complex|laminin binding|phosphatidylinositol-3,4-bisphosphate binding PLEKHA3 416.140132976823 451.827887942742 380.452378010905 0.842029427938095 -0.248057440219849 0.173900663341727 1 1.6341 1.78284 1.56095 1.25472 GeneID:65977,Genbank:XM_011511689.3,HGNC:HGNC:14338,MIM:607774 pleckstrin homology domain containing A3 GO:0000139,GO:0005794,GO:0006661,GO:0070273 Golgi membrane|Golgi apparatus|phosphatidylinositol biosynthetic process|phosphatidylinositol-4-phosphate binding PLEKHA4 610.567976621073 506.72467661622 714.411276625926 1.40986083684849 0.495552765534049 0.00332135721453719 0.216239256699299 3.38218 3.37492 5.49183 4.08864 GeneID:57664,Genbank:XM_011527158.3,HGNC:HGNC:14339,MIM:607769 pleckstrin homology domain containing A4 GO:0005737,GO:0005886,GO:0006661,GO:0032266 cytoplasm|plasma membrane|phosphatidylinositol biosynthetic process|phosphatidylinositol-3-phosphate binding PLEKHA5 2.26398300035667 2.10436443188427 2.42360156882906 1.15170240102325 0.203767973694901 1 1 0 0.00333802 0.0100374 0 GeneID:54477,Genbank:XM_017019502.1,HGNC:HGNC:30036,MIM:607770 pleckstrin homology domain containing A5 GO:0005654,GO:0005829,GO:0010314,GO:0016020,GO:0032266,GO:0061458,GO:0070273,GO:0080025 nucleoplasm|cytosol|phosphatidylinositol-5-phosphate binding|membrane|phosphatidylinositol-3-phosphate binding|reproductive system development|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-3,5-bisphosphate binding PLEKHA6 199.471122854282 220.086017750121 178.856227958443 0.812665110609208 -0.299267137173033 0.190796449237671 1 0.380275 0.390928 0.396807 0.261302 GeneID:22874,Genbank:NM_014935.4,HGNC:HGNC:17053,MIM:607771 pleckstrin homology domain containing A6 PLEKHA7 882.61634196894 809.544483401164 955.688200536716 1.18052586378151 0.239429649478945 0.124112676485383 1 2.01665 1.88647 2.37362 2.31087 GeneID:144100,Genbank:XM_024448364.1,HGNC:HGNC:27049,MIM:612686 pleckstrin homology domain containing A7 GO:0005634,GO:0005813,GO:0005829,GO:0005915,GO:0030054,GO:0045218,GO:0070062,GO:0070097,GO:0090136 nucleus|centrosome|cytosol|zonula adherens|cell junction|zonula adherens maintenance|extracellular exosome|delta-catenin binding|epithelial cell-cell adhesion PLEKHA8 370.442278913405 379.346363728592 361.538194098218 0.953055646941394 -0.0693676423233869 0.730399511083698 1 0.8904 0.828834 0.872606 0.764524 GeneID:84725,Genbank:NM_001350973.1,HGNC:HGNC:30037,MIM:608639 pleckstrin homology domain containing A8 GO:0000139,GO:0005654,GO:0005794,GO:0005802,GO:0006661,GO:0006869,GO:0015031,GO:0017089,GO:0035621,GO:0051861,GO:0070273,GO:0097001,GO:0120013 Golgi membrane|nucleoplasm|Golgi apparatus|trans-Golgi network|phosphatidylinositol biosynthetic process|lipid transport|protein transport|glycolipid transporter activity|ER to Golgi ceramide transport|glycolipid binding|phosphatidylinositol-4-phosphate binding|ceramide binding|intermembrane lipid transfer activity PLEKHB1 757.563686236815 639.954420362012 875.172952111619 1.36755513246795 0.451598995895184 0.00522661813918512 0.285941071095182 6.14922 6.25169 8.0176 8.87173 GeneID:58473,Genbank:NM_021200.2,HGNC:HGNC:19079,MIM:607651 pleckstrin homology domain containing B1 GO:0004871,GO:0005737,GO:0007275,GO:0007602,GO:0016021,GO:0045595 signal transducer activity|cytoplasm|multicellular organism development|phototransduction|integral component of membrane|regulation of cell differentiation PLEKHB2 5119.90014177624 4809.97991444565 5429.82036910683 1.12886549750439 0.1748736015732 0.185756114781079 1 41.8196 40.9083 49.2969 46.1327 GeneID:55041,Genbank:NM_001309452.1,HGNC:HGNC:19236 pleckstrin homology domain containing B2 GO:0005547,GO:0016021,GO:0045595,GO:0055038 phosphatidylinositol-3,4,5-trisphosphate binding|integral component of membrane|regulation of cell differentiation|recycling endosome membrane PLEKHD1 3.98899835201763 3.13253351048394 4.84546319355132 1.54681926859986 0.629304641178248 0.736682277186025 1 0.00715545 0 0.00677352 0.0126226 GeneID:400224,Genbank:XM_017021290.1,HGNC:HGNC:20148 pleckstrin homology and coiled-coil domain containing D1 PLEKHF1 258.468552987621 235.37428376017 281.562822215073 1.19623443018935 0.258500147169155 0.224870811874706 1 3.11049 3.16547 3.89904 3.9154 GeneID:79156,Genbank:NM_024310.4,HGNC:HGNC:20764,MIM:615200 pleckstrin homology and FYVE domain containing 1 GO:0005634,GO:0005764,GO:0005765,GO:0006915,GO:0007032,GO:0010008,GO:0010314,GO:0010508,GO:0016050,GO:0032266,GO:0046872,GO:0048471,GO:0070273,GO:0072659,GO:2001244 nucleus|lysosome|lysosomal membrane|apoptotic process|endosome organization|endosome membrane|phosphatidylinositol-5-phosphate binding|positive regulation of autophagy|vesicle organization|phosphatidylinositol-3-phosphate binding|metal ion binding|perinuclear region of cytoplasm|phosphatidylinositol-4-phosphate binding|protein localization to plasma membrane|positive regulation of intrinsic apoptotic signaling pathway PLEKHF2 246.549505234987 244.934563425037 248.164447044937 1.01318672046417 0.0189000733138248 0.929552204608464 1 4.72507 4.0143 5.26609 3.66407 GeneID:79666,Genbank:NM_024613.3,HGNC:HGNC:20757,MIM:615208 pleckstrin homology and FYVE domain containing 2 GO:0005783,GO:0015031,GO:0030133,GO:0031901,GO:0046872 endoplasmic reticulum|protein transport|transport vesicle|early endosome membrane|metal ion binding PLEKHG1 2369.79515773864 2466.06015619503 2273.53015928225 0.921928102025766 -0.117273850626915 0.402002874655244 1 11.7992 11.6154 11.9651 9.87255 GeneID:57480,Genbank:NM_001329804.1,HGNC:HGNC:20884 pleckstrin homology and RhoGEF domain containing G1 GO:0005089,GO:0005634,GO:0005654,GO:0035023 Rho guanyl-nucleotide exchange factor activity|nucleus|nucleoplasm|regulation of Rho protein signal transduction PLEKHG2 1099.71196065367 1119.14885457436 1080.27506673297 0.965264863844972 -0.0510032298897985 0.732717469535495 1 4.76523 4.83124 4.99639 4.46264 GeneID:64857,Genbank:XM_017027150.1,HGNC:HGNC:29515,MIM:611893 pleckstrin homology and RhoGEF domain containing G2 GO:0005085,GO:0005089,GO:0005829,GO:0007186,GO:0030833,GO:0035023,GO:0043065,GO:0051056 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytosol|G-protein coupled receptor signaling pathway|regulation of actin filament polymerization|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction PLEKHG3 106.26966348453 116.0968619875 96.4424649815605 0.830706905686599 -0.267588547252745 0.353335705113289 1 0.457161 0.475533 0.388625 0.358797 GeneID:26030,Genbank:XM_011536628.3,HGNC:HGNC:20364 pleckstrin homology and RhoGEF domain containing G3 GO:0005089,GO:0035023 Rho guanyl-nucleotide exchange factor activity|regulation of Rho protein signal transduction PLEKHG4 23.7778979536807 29.6247981806506 17.9309977267107 0.605269869430617 -0.724349559971694 0.213513826836939 1 0.212896 0.235035 0.13094 0.139969 GeneID:25894,Genbank:XM_011522987.2,HGNC:HGNC:24501,MIM:609526 pleckstrin homology and RhoGEF domain containing G4 GO:0005089,GO:0035023,GO:0090630 Rho guanyl-nucleotide exchange factor activity|regulation of Rho protein signal transduction|activation of GTPase activity PLEKHG4B 4.43735153674034 4.99676656894351 3.87793650453717 0.776089187083459 -0.36570564045246 0.850844970055072 1 0.00277588 0.0196624 0.0129423 0.00484936 GeneID:153478,Genbank:XM_017009112.2,HGNC:HGNC:29399 pleckstrin homology and RhoGEF domain containing G4B GO:0005089,GO:0035023 Rho guanyl-nucleotide exchange factor activity|regulation of Rho protein signal transduction PLEKHG5 527.242202556109 526.231480145144 528.252924967074 1.00384136050046 0.00553129468446623 1 1 2.90648 3.24826 3.3739 3.15787 GeneID:57449,Genbank:NM_198681.3,HGNC:HGNC:29105,MIM:611101 pleckstrin homology and RhoGEF domain containing G5 GO:0004871,GO:0005085,GO:0005089,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0007186,GO:0030027,GO:0030139,GO:0035023,GO:0035767,GO:0043065,GO:0043123,GO:0048471,GO:0051056 signal transducer activity|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|plasma membrane|cell-cell junction|G-protein coupled receptor signaling pathway|lamellipodium|endocytic vesicle|regulation of Rho protein signal transduction|endothelial cell chemotaxis|positive regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction hsa05200 Pathways in cancer PLEKHG6 1.02229600717608 1.07619535328461 0.968396661067546 0.899833527539349 -0.152269972565186 1 1 0.0219523 0 0 0 GeneID:55200,Genbank:NM_018173.3,HGNC:HGNC:25562,MIM:611743 pleckstrin homology and RhoGEF domain containing G6 GO:0000922,GO:0005089,GO:0005096,GO:0005737,GO:0005813,GO:0005902,GO:0030054,GO:0032154,GO:0035023 spindle pole|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|cytoplasm|centrosome|microvillus|cell junction|cleavage furrow|regulation of Rho protein signal transduction PLEKHH1 62.5335677815256 60.6139493626954 64.4531862003558 1.06333916331186 0.0886018331668395 0.824647927406835 1 0.218462 0.198177 0.223328 0.220613 GeneID:57475,Genbank:XM_017021499.1,HGNC:HGNC:17733 pleckstrin homology, MyTH4 and FERM domain containing H1 GO:0005856 cytoskeleton PLEKHH2 77.0031635948621 70.155628718202 83.8506984715222 1.1952098499228 0.257263942778131 0.433767954475362 1 0.292043 0.269815 0.364347 0.282736 GeneID:130271,Genbank:XM_017003353.1,HGNC:HGNC:30506,MIM:612723 pleckstrin homology, MyTH4 and FERM domain containing H2 GO:0003779,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0016604,GO:0030027,GO:0030835,GO:0030864,GO:0042802 actin binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|nuclear body|lamellipodium|negative regulation of actin filament depolymerization|cortical actin cytoskeleton|identical protein binding PLEKHH3 705.014102256114 627.876140102456 782.152064409771 1.2457107611736 0.316969131073959 0.0532227172651427 0.841475853621447 8.01489 7.53011 9.28279 9.97409 GeneID:79990,Genbank:XM_017025115.2,HGNC:HGNC:26105 pleckstrin homology, MyTH4 and FERM domain containing H3 GO:0005615,GO:0005856,GO:0007165 extracellular space|cytoskeleton|signal transduction PLEKHJ1 1277.73416477072 1139.35846891505 1416.10986062639 1.24290107043736 0.313711468659573 0.0373919663655873 0.744556882325193 19.5302 21.5532 28.4069 24.5061 GeneID:55111,Genbank:NM_001300836.1,HGNC:HGNC:18211,MIM:617834 pleckstrin homology domain containing J1 GO:0001881,GO:0005769,GO:0005802,GO:0005829,GO:0007032,GO:0042147,GO:0055037 receptor recycling|early endosome|trans-Golgi network|cytosol|endosome organization|retrograde transport, endosome to Golgi|recycling endosome PLEKHM1 973.93944905395 829.320844268837 1118.55805383906 1.34876394530422 0.431637876278433 0.00530065035682074 0.285941071095182 4.12588 4.32841 6.23682 5.57554 GeneID:9842,Genbank:XM_011525523.2,HGNC:HGNC:29017,MIM:611466 pleckstrin homology and RUN domain containing M1 GO:0005730,GO:0005765,GO:0006914,GO:0010008,GO:0015031,GO:0032418,GO:0035556,GO:0043231,GO:0045780,GO:0046872,GO:1900029 nucleolus|lysosomal membrane|autophagy|endosome membrane|protein transport|lysosome localization|intracellular signal transduction|intracellular membrane-bounded organelle|positive regulation of bone resorption|metal ion binding|positive regulation of ruffle assembly PLEKHM2 2508.88925584542 2214.75771554711 2803.02079614373 1.26561057964361 0.339833564923006 0.0151754426825246 0.511744031201217 18.0258 19.4334 23.5582 24.3977 GeneID:23207,Genbank:XM_017000757.1,HGNC:HGNC:29131,MIM:609613 pleckstrin homology and RUN domain containing M2 GO:0007030,GO:0010008,GO:0019894,GO:0032418,GO:0032880,GO:1903527 Golgi organization|endosome membrane|kinesin binding|lysosome localization|regulation of protein localization|positive regulation of membrane tubulation hsa05132 Salmonella infection PLEKHM3 234.814372609829 254.457642471183 215.171102748476 0.845606760554828 -0.24194118389532 0.264731274194484 1 0.525822 0.545042 0.480715 0.46775 GeneID:389072,Genbank:XM_017004073.1,HGNC:HGNC:34006 pleckstrin homology domain containing M3 GO:0046872 metal ion binding PLEKHN1 50.1407559887695 57.1452319294168 43.1362800481222 0.754853530061829 -0.405731360321556 0.311561883548119 1 0.68489 0.833763 0.594899 0.446624 GeneID:84069,Genbank:XM_011542248.2,HGNC:HGNC:25284 pleckstrin homology domain containing N1 GO:0005886 plasma membrane PLEKHO1 462.545820621104 472.458913099636 452.632728142573 0.958036171173085 -0.061847968167135 0.719620267963339 1 3.0588 3.4102 3.42758 3.34459 GeneID:51177,Genbank:NM_001304722.1,HGNC:HGNC:24310,MIM:608335 pleckstrin homology domain containing O1 GO:0005634,GO:0005737,GO:0007520,GO:0008360,GO:0032587,GO:0036195,GO:0051451,GO:0072673 nucleus|cytoplasm|myoblast fusion|regulation of cell shape|ruffle membrane|muscle cell projection membrane|myoblast migration|lamellipodium morphogenesis PLEKHO2 202.254156294851 211.630342403007 192.877970186694 0.91139090924588 -0.133858114551463 0.5467947115419 1 1.96467 2.24018 2.01467 2.05377 GeneID:80301,Genbank:NM_025201.4,HGNC:HGNC:30026 pleckstrin homology domain containing O2 GO:0005576,GO:0043312,GO:1904813 extracellular region|neutrophil degranulation|ficolin-1-rich granule lumen PLEKHS1 27.2760038701341 17.719005709619 36.8330020306492 2.0787284926859 1.0557013369192 0.0494457483435209 0.813062736622003 0.137776 0.0455328 0.191989 0.209095 GeneID:79949,Genbank:XM_011540172.1,HGNC:HGNC:26285 pleckstrin homology domain containing S1 PLG 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00742307 GeneID:5340,Genbank:NM_000301.3,HGNC:HGNC:9071,MIM:173350 plasminogen hsa04080,hsa04610,hsa05150,hsa05164 Neuroactive ligand-receptor interaction|Complement and coagulation cascades|Staphylococcus aureus infection|Influenza A PLGLB1 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0.0275341 0 0.0128032 GeneID:5343,Genbank:NM_001032392.2,HGNC:HGNC:9072,MIM:173340 plasminogen-like B1 PLGLB2 4.41810074483787 1.56626675524197 7.26993473443377 4.64156869198864 2.21461246950733 0.15864996609693 1 0.0286722 0.0137988 0.0689347 0.0898222 GeneID:5342,Genbank:NM_002665.4,HGNC:HGNC:9073 plasminogen-like B2 PLGRKT 478.372242014643 477.493897288157 479.250586741129 1.00367897781092 0.00529790357308246 0.990447320290526 1 7.27865 7.74297 7.1322 8.5296 GeneID:55848,Genbank:XM_005251510.5,HGNC:HGNC:23633 plasminogen receptor with a C-terminal lysine GO:0005739,GO:0005887,GO:0006935,GO:0006954,GO:0010756 mitochondrion|integral component of plasma membrane|chemotaxis|inflammatory response|positive regulation of plasminogen activation PLIN1 2.98984551013063 2.10436443188427 3.87532658837698 1.84156628465107 0.880933326000264 0.686989821161197 1 0.034827 0.0152878 0.016193 0.0756827 GeneID:5346,Genbank:XM_005254934.4,HGNC:HGNC:9076,MIM:170290 perilipin 1 hsa03320,hsa04371,hsa04714,hsa04923 PPAR signaling pathway|Apelin signaling pathway|Thermogenesis|Regulation of lipolysis in adipocytes PLIN2 2.01807732732459 1.61429302992691 2.42186162472226 1.50026146419768 0.585213954207341 0.88970252031993 1 0.0183712 0 0 0.048667 GeneID:123,Genbank:XM_017014259.2,HGNC:HGNC:248,MIM:103195 perilipin 2 GO:0005576,GO:0005634,GO:0005783,GO:0005811,GO:0005829,GO:0005886,GO:0014070,GO:0015909,GO:0019216,GO:0019915,GO:0042493 extracellular region|nucleus|endoplasmic reticulum|lipid droplet|cytosol|plasma membrane|response to organic cyclic compound|long-chain fatty acid transport|regulation of lipid metabolic process|lipid storage|response to drug hsa03320 PPAR signaling pathway PLIN3 3789.26778154383 3576.17127947436 4002.36428361329 1.11917578069739 0.16243664759579 0.239118847367135 1 62.8914 67.2654 71.5765 76.124 GeneID:10226,Genbank:NM_001164194.1,HGNC:HGNC:16893,MIM:602702 perilipin 3 GO:0005737,GO:0005768,GO:0005794,GO:0005811,GO:0005829,GO:0010008,GO:0016020,GO:0016192,GO:0030133,GO:0045296 cytoplasm|endosome|Golgi apparatus|lipid droplet|cytosol|endosome membrane|membrane|vesicle-mediated transport|transport vesicle|cadherin binding PLIN4 1.48585272210587 1.51824048055703 1.45346496365472 0.957335140426142 -0.0629040282857778 1 1 0 0.00787979 0.00424387 0.00792519 GeneID:729359,Genbank:NM_001080400.1,HGNC:HGNC:29393,MIM:613247 perilipin 4 GO:0005811,GO:0005829,GO:0005886,GO:0043231 lipid droplet|cytosol|plasma membrane|intracellular membrane-bounded organelle hsa03320 PPAR signaling pathway PLIN5 3.65084663738086 2.94042841174417 4.36126486301754 1.48320729237906 0.568720242288897 0.833483601829254 1 0 0.0952634 0.0818747 0 GeneID:440503,Genbank:NM_001013706.2,HGNC:HGNC:33196,MIM:613248 perilipin 5 GO:0005737,GO:0005739,GO:0005811,GO:0005829,GO:0010867,GO:0010884,GO:0010890,GO:0010897,GO:0019915,GO:0031999,GO:0032000,GO:0034389,GO:0035359,GO:0035473,GO:0042802,GO:0051646,GO:0060192,GO:0060193,GO:2000378 cytoplasm|mitochondrion|lipid droplet|cytosol|positive regulation of triglyceride biosynthetic process|positive regulation of lipid storage|positive regulation of sequestering of triglyceride|negative regulation of triglyceride catabolic process|lipid storage|negative regulation of fatty acid beta-oxidation|positive regulation of fatty acid beta-oxidation|lipid particle organization|negative regulation of peroxisome proliferator activated receptor signaling pathway|lipase binding|identical protein binding|mitochondrion localization|negative regulation of lipase activity|positive regulation of lipase activity|negative regulation of reactive oxygen species metabolic process hsa03320 PPAR signaling pathway PLK1 4019.80868009108 4237.79470272698 3801.82265745518 0.897122896257516 -0.156622462388892 0.230604794201305 1 76.2072 82.4251 72.804 72.7688 GeneID:5347,Genbank:NM_005030.5,HGNC:HGNC:9077,MIM:602098 polo like kinase 1 hsa04068,hsa04110,hsa04114,hsa04914 FoxO signaling pathway|Cell cycle|Oocyte meiosis|Progesterone-mediated oocyte maturation PLK2 4440.21289426438 4590.83582187987 4289.5899666489 0.934381043688116 -0.0979170891353574 0.46615754318213 1 52.3006 52.5445 52.7554 46.199 GeneID:10769,Genbank:NM_001252226.1,HGNC:HGNC:19699,MIM:607023 polo like kinase 2 GO:0000082,GO:0000785,GO:0004674,GO:0004871,GO:0005524,GO:0005622,GO:0005737,GO:0005813,GO:0005814,GO:0005829,GO:0006468,GO:0006977,GO:0007052,GO:0007093,GO:0007265,GO:0007613,GO:0010508,GO:0016525,GO:0018105,GO:0030425,GO:0032092,GO:0032403,GO:0032436,GO:0032486,GO:0043008,GO:0043066,GO:0043123,GO:0045732,GO:0046599,GO:0048167,GO:0060291,GO:0060292,GO:0061000 G1/S transition of mitotic cell cycle|chromatin|protein serine/threonine kinase activity|signal transducer activity|ATP binding|intracellular|cytoplasm|centrosome|centriole|cytosol|protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|mitotic spindle organization|mitotic cell cycle checkpoint|Ras protein signal transduction|memory|positive regulation of autophagy|negative regulation of angiogenesis|peptidyl-serine phosphorylation|dendrite|positive regulation of protein binding|protein complex binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|Rap protein signal transduction|ATP-dependent protein binding|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of protein catabolic process|regulation of centriole replication|regulation of synaptic plasticity|long-term synaptic potentiation|long term synaptic depression|negative regulation of dendritic spine development hsa04068 FoxO signaling pathway PLK3 233.520967483797 244.58958784799 222.452347119603 0.909492301274312 -0.136866669171547 0.511689483405526 1 4.21058 4.73039 4.48473 3.90442 GeneID:1263,Genbank:NM_004073.3,HGNC:HGNC:2154,MIM:602913 polo like kinase 3 hsa04068,hsa04625,hsa05152 FoxO signaling pathway|C-type lectin receptor signaling pathway|Tuberculosis PLK4 358.130078968701 381.81532104774 334.444836889662 0.87593351668527 -0.191106721394645 0.53305539175465 1 3.27017 2.62118 2.9993 2.0288 GeneID:10733,Genbank:NM_014264.4,HGNC:HGNC:11397,MIM:605031 polo like kinase 4 GO:0000086,GO:0001741,GO:0004674,GO:0005524,GO:0005730,GO:0005813,GO:0005814,GO:0005829,GO:0006468,GO:0007099,GO:0010389,GO:0032154,GO:0042802,GO:0046601,GO:0060707,GO:0097711,GO:0098535,GO:0098536 G2/M transition of mitotic cell cycle|XY body|protein serine/threonine kinase activity|ATP binding|nucleolus|centrosome|centriole|cytosol|protein phosphorylation|centriole replication|regulation of G2/M transition of mitotic cell cycle|cleavage furrow|identical protein binding|positive regulation of centriole replication|trophoblast giant cell differentiation|ciliary basal body-plasma membrane docking|de novo centriole assembly involved in multi-ciliated epithelial cell differentiation|deuterosome hsa04068 FoxO signaling pathway PLK5 0.780631827935889 1.07619535328461 0.48506830258717 0.450725141217823 -1.14968016979823 0.981241458110389 1 0.0296861 0 0.0269098 0 GeneID:126520,Genbank:NM_001243079.1,HGNC:HGNC:27001 polo like kinase 5 GO:0002357,GO:0005524,GO:0005730,GO:0005737,GO:0006468,GO:0006974,GO:0007049,GO:0008285,GO:0010976,GO:0042981,GO:0046872,GO:0051301,GO:0071363,GO:2000045 defense response to tumor cell|ATP binding|nucleolus|cytoplasm|protein phosphorylation|cellular response to DNA damage stimulus|cell cycle|negative regulation of cell proliferation|positive regulation of neuron projection development|regulation of apoptotic process|metal ion binding|cell division|cellular response to growth factor stimulus|regulation of G1/S transition of mitotic cell cycle PLLP 47.2256456724479 51.3124013806134 43.1388899642824 0.840710799019064 -0.250318490096919 0.561964285969522 1 1.90463 1.61657 1.85117 1.25716 GeneID:51090,Genbank:NM_015993.2,HGNC:HGNC:18553,MIM:600340 plasmolipin GO:0001766,GO:0006811,GO:0008104,GO:0009611,GO:0016021,GO:0019911,GO:0042552,GO:0043218,GO:0045121,GO:0070062 membrane raft polarization|ion transport|protein localization|response to wounding|integral component of membrane|structural constituent of myelin sheath|myelination|compact myelin|membrane raft|extracellular exosome PLN 44.5980379737232 40.7327442913992 48.4633316560471 1.18978803169617 0.250704571130064 0.560987461442582 1 0.602315 0.569517 0.771707 0.706028 GeneID:5350,Genbank:NM_002667.4,HGNC:HGNC:9080,MIM:172405 phospholamban GO:0002026,GO:0004857,GO:0005246,GO:0005739,GO:0005783,GO:0006816,GO:0007219,GO:0008015,GO:0008016,GO:0010043,GO:0010459,GO:0010881,GO:0016020,GO:0031966,GO:0031982,GO:0032780,GO:0032868,GO:0033017,GO:0033574,GO:0042030,GO:0042802,GO:0043086,GO:0043234,GO:0048471,GO:0048738,GO:0051117,GO:0051260,GO:0051480,GO:0051924,GO:0051926,GO:0055119,GO:0060314,GO:0086004,GO:0086023,GO:0086036,GO:0086092,GO:0090281,GO:0090534,GO:1901020,GO:1901877,GO:1901894,GO:1901895,GO:1901897,GO:1902081,GO:1903779 regulation of the force of heart contraction|enzyme inhibitor activity|calcium channel regulator activity|mitochondrion|endoplasmic reticulum|calcium ion transport|Notch signaling pathway|blood circulation|regulation of heart contraction|response to zinc ion|negative regulation of heart rate|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|membrane|mitochondrial membrane|vesicle|negative regulation of ATPase activity|response to insulin|sarcoplasmic reticulum membrane|response to testosterone|ATPase inhibitor activity|identical protein binding|negative regulation of catalytic activity|protein complex|perinuclear region of cytoplasm|cardiac muscle tissue development|ATPase binding|protein homooligomerization|regulation of cytosolic calcium ion concentration|regulation of calcium ion transport|negative regulation of calcium ion transport|relaxation of cardiac muscle|regulation of ryanodine-sensitive calcium-release channel activity|regulation of cardiac muscle cell contraction|adrenergic receptor signaling pathway involved in heart process|regulation of cardiac muscle cell membrane potential|regulation of the force of heart contraction by cardiac conduction|negative regulation of calcium ion import|calcium ion-transporting ATPase complex|negative regulation of calcium ion transmembrane transporter activity|negative regulation of calcium ion binding|regulation of calcium-transporting ATPase activity|negative regulation of calcium-transporting ATPase activity|regulation of relaxation of cardiac muscle|negative regulation of calcium ion import into sarcoplasmic reticulum|regulation of cardiac conduction hsa04020,hsa04022,hsa04024,hsa04261,hsa04919,hsa05414 Calcium signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Adrenergic signaling in cardiomyocytes|Thyroid hormone signaling pathway|Dilated cardiomyopathy (DCM) PLOD1 5586.38047028152 5186.52622193657 5986.23471862646 1.15418961795806 0.206880259005345 0.147094153577782 1 50.8075 53.0339 58.2741 63.7361 GeneID:5351,Genbank:NM_001316320.1,HGNC:HGNC:9081,MIM:153454 procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 GO:0001666,GO:0005506,GO:0005789,GO:0006464,GO:0008475,GO:0008544,GO:0017185,GO:0030867,GO:0031418,GO:0042803,GO:0046947,GO:0055114,GO:0070062,GO:1902494 response to hypoxia|iron ion binding|endoplasmic reticulum membrane|cellular protein modification process|procollagen-lysine 5-dioxygenase activity|epidermis development|peptidyl-lysine hydroxylation|rough endoplasmic reticulum membrane|L-ascorbic acid binding|protein homodimerization activity|hydroxylysine biosynthetic process|oxidation-reduction process|extracellular exosome|catalytic complex hsa00310 Lysine degradation PLOD2 1737.30376698598 1835.37582384807 1639.2317101239 0.893131362429671 -0.163055711267527 0.534716834930299 1 16.3338 13.9905 15.9322 11.2119 GeneID:5352,Genbank:XM_024453599.1,HGNC:HGNC:9082,MIM:601865 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 hsa00310 Lysine degradation PLOD3 4030.88172444741 3818.89663426389 4242.86681463092 1.11101902485736 0.151883521346595 0.270869371781917 1 44.4253 46.7394 53.1087 51.3942 GeneID:8985,Genbank:NM_001084.4,HGNC:HGNC:9083,MIM:603066 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 GO:0001701,GO:0001886,GO:0005506,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0006493,GO:0008104,GO:0008475,GO:0017185,GO:0021915,GO:0030199,GO:0030867,GO:0031012,GO:0031418,GO:0032870,GO:0032963,GO:0033823,GO:0042311,GO:0046947,GO:0048730,GO:0050211,GO:0060425,GO:0070062,GO:0070831 in utero embryonic development|endothelial cell morphogenesis|iron ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|protein O-linked glycosylation|protein localization|procollagen-lysine 5-dioxygenase activity|peptidyl-lysine hydroxylation|neural tube development|collagen fibril organization|rough endoplasmic reticulum membrane|extracellular matrix|L-ascorbic acid binding|cellular response to hormone stimulus|collagen metabolic process|procollagen glucosyltransferase activity|vasodilation|hydroxylysine biosynthetic process|epidermis morphogenesis|procollagen galactosyltransferase activity|lung morphogenesis|extracellular exosome|basement membrane assembly hsa00310,hsa00514 Lysine degradation|Other types of O-glycan biosynthesis PLP1 13.280187703418 9.59951428529953 16.9608611215364 1.76684576088499 0.821176103433028 0.322485362393877 1 0.0836912 0.172807 0.200744 0.236875 GeneID:5354,Genbank:NM_001128834.2,HGNC:HGNC:9086,MIM:300401 proteolipid protein 1 GO:0005198,GO:0005886,GO:0005887,GO:0006954,GO:0007229,GO:0008366,GO:0010001,GO:0010628,GO:0014002,GO:0019911,GO:0021762,GO:0022010,GO:0042552,GO:0042759,GO:0042802,GO:0043209,GO:0048469,GO:0061564 structural molecule activity|plasma membrane|integral component of plasma membrane|inflammatory response|integrin-mediated signaling pathway|axon ensheathment|glial cell differentiation|positive regulation of gene expression|astrocyte development|structural constituent of myelin sheath|substantia nigra development|central nervous system myelination|myelination|long-chain fatty acid biosynthetic process|identical protein binding|myelin sheath|cell maturation|axon development PLP2 4764.41720131784 4738.93445482122 4789.89994781446 1.0107546313373 0.0154328141384731 0.922145954998623 1 205.579 215.686 212.029 218.123 GeneID:5355,Genbank:NM_002668.2,HGNC:HGNC:9087,MIM:300112 proteolipid protein 2 GO:0005783,GO:0005789,GO:0005886,GO:0006811,GO:0006935,GO:0015075,GO:0016020,GO:0016021,GO:0019221,GO:0019956,GO:0070062 endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|ion transport|chemotaxis|ion transmembrane transporter activity|membrane|integral component of membrane|cytokine-mediated signaling pathway|chemokine binding|extracellular exosome PLPBP 1228.88342317983 1252.05222305246 1205.7146233072 0.962990681305371 -0.0544062574620086 0.706409026060873 1 10.6669 11.5475 10.2672 10.6929 GeneID:11212,Genbank:NM_001349349.1,HGNC:HGNC:9457,MIM:604436 pyridoxal phosphate binding protein GO:0005622,GO:0005737,GO:0005739,GO:0030170,GO:0070062 intracellular|cytoplasm|mitochondrion|pyridoxal phosphate binding|extracellular exosome PLPP1 2134.37776968341 1676.96440150713 2591.79113785969 1.54552543603811 0.628097398061597 7.51501643512673e-06 0.00383909174838642 39.979 40.9656 66.1313 61.1624 GeneID:8611,Genbank:NM_003711.3,HGNC:HGNC:9228,MIM:607124 phospholipid phosphatase 1 GO:0005886,GO:0005887,GO:0006470,GO:0006629,GO:0006644,GO:0007205,GO:0008195,GO:0008285,GO:0008354,GO:0016020,GO:0019216,GO:0030148,GO:0030518,GO:0030521,GO:0042392,GO:0042577,GO:0046839,GO:0070062 plasma membrane|integral component of plasma membrane|protein dephosphorylation|lipid metabolic process|phospholipid metabolic process|protein kinase C-activating G-protein coupled receptor signaling pathway|phosphatidate phosphatase activity|negative regulation of cell proliferation|germ cell migration|membrane|regulation of lipid metabolic process|sphingolipid biosynthetic process|intracellular steroid hormone receptor signaling pathway|androgen receptor signaling pathway|sphingosine-1-phosphate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation|extracellular exosome hsa00561,hsa00564,hsa00565,hsa00600,hsa04072,hsa04666,hsa04975,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Sphingolipid metabolism|Phospholipase D signaling pathway|Fc gamma R-mediated phagocytosis|Fat digestion and absorption|Choline metabolism in cancer PLPP2 1740.00407554889 1612.24961848685 1867.75853261094 1.1584797485416 0.212232824579107 0.146156673788594 1 40.4369 45.3481 51.8775 49.6075 GeneID:8612,Genbank:NM_177526.2,HGNC:HGNC:9230,MIM:607126 phospholipid phosphatase 2 GO:0004721,GO:0005886,GO:0005887,GO:0006644,GO:0007165,GO:0008195,GO:0016020,GO:0030148,GO:0042392,GO:0042577,GO:0046839 phosphoprotein phosphatase activity|plasma membrane|integral component of plasma membrane|phospholipid metabolic process|signal transduction|phosphatidate phosphatase activity|membrane|sphingolipid biosynthetic process|sphingosine-1-phosphate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation hsa00561,hsa00564,hsa00565,hsa00600,hsa04072,hsa04666,hsa04975,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Sphingolipid metabolism|Phospholipase D signaling pathway|Fc gamma R-mediated phagocytosis|Fat digestion and absorption|Choline metabolism in cancer PLPP3 103.292422974515 115.45290310638 91.1319428426502 0.789343016854931 -0.341275720916168 0.308056023953639 1 1.58806 1.55577 1.61859 0.925432 GeneID:8613,Genbank:NM_003713.4,HGNC:HGNC:9229,MIM:607125 phospholipid phosphatase 3 GO:0001933,GO:0004721,GO:0005794,GO:0005886,GO:0005887,GO:0005912,GO:0006629,GO:0006644,GO:0008195,GO:0008354,GO:0016020,GO:0030111,GO:0030148,GO:0034109,GO:0042392,GO:0042577,GO:0044328,GO:0044329,GO:0044330,GO:0046839,GO:0050821,GO:0051091,GO:0070062 negative regulation of protein phosphorylation|phosphoprotein phosphatase activity|Golgi apparatus|plasma membrane|integral component of plasma membrane|adherens junction|lipid metabolic process|phospholipid metabolic process|phosphatidate phosphatase activity|germ cell migration|membrane|regulation of Wnt signaling pathway|sphingolipid biosynthetic process|homotypic cell-cell adhesion|sphingosine-1-phosphate phosphatase activity|lipid phosphatase activity|canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt signaling pathway involved in positive regulation of wound healing|phospholipid dephosphorylation|protein stabilization|positive regulation of DNA binding transcription factor activity|extracellular exosome hsa00561,hsa00564,hsa00565,hsa00600,hsa04072,hsa04666,hsa04975,hsa05231 Glycerolipid metabolism|Glycerophospholipid metabolism|Ether lipid metabolism|Sphingolipid metabolism|Phospholipase D signaling pathway|Fc gamma R-mediated phagocytosis|Fat digestion and absorption|Choline metabolism in cancer PLPP4 836.460644738408 920.819100609954 752.102188866861 0.816775182409516 -0.291989064076479 0.0915662752208756 0.983401187832981 1.38634 1.72851 1.198 1.48466 GeneID:196051,Genbank:XM_005269592.2,HGNC:HGNC:23531 phospholipid phosphatase 4 GO:0005886,GO:0005887,GO:0006644,GO:0007165,GO:0008195,GO:0038096,GO:0042802,GO:0046839 plasma membrane|integral component of plasma membrane|phospholipid metabolic process|signal transduction|phosphatidate phosphatase activity|Fc-gamma receptor signaling pathway involved in phagocytosis|identical protein binding|phospholipid dephosphorylation hsa00561,hsa00564 Glycerolipid metabolism|Glycerophospholipid metabolism PLPP5 390.740678723294 394.740490943118 386.74086650347 0.979734472081809 -0.0295372923092726 0.876557855973006 1 1.7995 1.91344 1.89645 1.68428 GeneID:84513,Genbank:XM_024447307.1,HGNC:HGNC:25026,MIM:610626 phospholipid phosphatase 5 GO:0005737,GO:0005886,GO:0005887,GO:0006644,GO:0007165,GO:0008195,GO:0046839 cytoplasm|plasma membrane|integral component of plasma membrane|phospholipid metabolic process|signal transduction|phosphatidate phosphatase activity|phospholipid dephosphorylation hsa00561,hsa00564 Glycerolipid metabolism|Glycerophospholipid metabolism PLPP6 239.985115327942 212.436980417543 267.533250238341 1.25935347844103 0.332683279100291 0.117023574395284 1 3.76958 3.41166 5.04582 4.13004 GeneID:403313,Genbank:NM_203453.3,HGNC:HGNC:23682,MIM:611666 phospholipid phosphatase 6 GO:0005886,GO:0006695,GO:0016021,GO:0016787,GO:0042577,GO:0046839 plasma membrane|cholesterol biosynthetic process|integral component of membrane|hydrolase activity|lipid phosphatase activity|phospholipid dephosphorylation PLPP7 6.49845203937967 5.72696934432558 7.26993473443377 1.26942092708022 0.344170531525666 0.813115528232738 1 0.105505 0.0731376 0.117331 0.127998 GeneID:84814,Genbank:NM_032728.3,HGNC:HGNC:28174 phospholipid phosphatase 7 (inactive) GO:0005635,GO:0005789,GO:0010832,GO:0016021 nuclear envelope|endoplasmic reticulum membrane|negative regulation of myotube differentiation|integral component of membrane PLPPR1 6.99602809039232 8.17732635411239 5.81472982667226 0.711079584557369 -0.491917058501395 0.701966609386676 1 0.128035 0.120048 0.0871904 0.0973482 GeneID:54886,Genbank:NM_207299.1,HGNC:HGNC:25993 phospholipid phosphatase related 1 GO:0005654,GO:0005887,GO:0006644,GO:0007165,GO:0007399,GO:0008195,GO:0042577,GO:0046839 nucleoplasm|integral component of plasma membrane|phospholipid metabolic process|signal transduction|nervous system development|phosphatidate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation PLPPR2 1532.31372919844 1466.82490762106 1597.80255077582 1.0892933045207 0.123392468291323 0.404380415821937 1 24.4096 25.1043 27.7089 27.2607 GeneID:64748,Genbank:NM_022737.2,HGNC:HGNC:29566 phospholipid phosphatase related 2 GO:0005887,GO:0006644,GO:0007165,GO:0008195,GO:0042577,GO:0046839 integral component of plasma membrane|phospholipid metabolic process|signal transduction|phosphatidate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation PLPPR3 268.543698610325 279.796259548056 257.291137672593 0.919566037402307 -0.120974911319393 0.734210999541711 1 3.23436 2.43569 2.17359 3.01978 GeneID:79948,Genbank:XM_011528317.3,HGNC:HGNC:23497,MIM:610391 phospholipid phosphatase related 3 GO:0005887,GO:0006644,GO:0007165,GO:0008195,GO:0042577,GO:0046839 integral component of plasma membrane|phospholipid metabolic process|signal transduction|phosphatidate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation PLPPR4 42.8348830648574 41.5589996161511 44.1107665135636 1.06140106645928 0.085969903433241 0.865196976731301 1 0.377172 0.211787 0.41367 0.242892 GeneID:9890,Genbank:XM_011542498.2,HGNC:HGNC:23496,MIM:607813 phospholipid phosphatase related 4 GO:0005886,GO:0005887,GO:0006644,GO:0007165,GO:0007409,GO:0008195,GO:0042577,GO:0046839,GO:0048839 plasma membrane|integral component of plasma membrane|phospholipid metabolic process|signal transduction|axonogenesis|phosphatidate phosphatase activity|lipid phosphatase activity|phospholipid dephosphorylation|inner ear development PLPPR5 9.45038584004084 9.20549543271206 9.69527624736962 1.05320526399015 0.0747866372006643 1 1 0.0667472 0.082397 0.0732743 0.0427352 GeneID:163404,Genbank:NM_001010861.2,HGNC:HGNC:31703,MIM:617287 phospholipid phosphatase related 5 GO:0005886,GO:0005887,GO:0006644,GO:0007165,GO:0008195,GO:0010976,GO:0042577,GO:0046839,GO:0051491 plasma membrane|integral component of plasma membrane|phospholipid metabolic process|signal transduction|phosphatidate phosphatase activity|positive regulation of neuron projection development|lipid phosphatase activity|phospholipid dephosphorylation|positive regulation of filopodium assembly PLRG1 988.686196356662 967.382641448447 1009.98975126488 1.04404369893658 0.0621820978462128 0.679875112688031 1 9.67561 9.49966 10.8099 9.54108 GeneID:5356,Genbank:NM_001201564.1,HGNC:HGNC:9089,MIM:605961 pleiotropic regulator 1 GO:0000398,GO:0000974,GO:0001650,GO:0005654,GO:0016607,GO:0031965,GO:0034504,GO:0071011,GO:0071013,GO:0080008,GO:1900087 mRNA splicing, via spliceosome|Prp19 complex|fibrillar center|nucleoplasm|nuclear speck|nuclear membrane|protein localization to nucleus|precatalytic spliceosome|catalytic step 2 spliceosome|Cul4-RING E3 ubiquitin ligase complex|positive regulation of G1/S transition of mitotic cell cycle hsa03040 Spliceosome PLS1 283.105138740958 322.431454517492 243.778822964424 0.756064023993042 -0.403419686914168 0.0569237630153275 0.86572937197041 2.81101 2.36745 2.04107 1.74425 GeneID:5357,Genbank:NM_001145319.1,HGNC:HGNC:9090,MIM:602734 plastin 1 GO:0001951,GO:0005200,GO:0005509,GO:0005737,GO:0005884,GO:0005903,GO:0032432,GO:0032532,GO:0040018,GO:0051015,GO:0051017,GO:0051639,GO:0051764,GO:0070062,GO:1902896,GO:1903078,GO:1990357 intestinal D-glucose absorption|structural constituent of cytoskeleton|calcium ion binding|cytoplasm|actin filament|brush border|actin filament bundle|regulation of microvillus length|positive regulation of multicellular organism growth|actin filament binding|actin filament bundle assembly|actin filament network formation|actin crosslink formation|extracellular exosome|terminal web assembly|positive regulation of protein localization to plasma membrane|terminal web PLS3 5388.23394403383 5550.88090760404 5225.58698046361 0.941397783062717 -0.0871236393195005 0.533626091440897 1 47.5244 43.2287 47.0112 38.385 GeneID:5358,Genbank:NM_001282337.1,HGNC:HGNC:9091,MIM:300131 plastin 3 GO:0005509,GO:0005737,GO:0005829,GO:0005884,GO:0005886,GO:0032432,GO:0051015,GO:0051017,GO:0051639,GO:0051764,GO:0060348 calcium ion binding|cytoplasm|cytosol|actin filament|plasma membrane|actin filament bundle|actin filament binding|actin filament bundle assembly|actin filament network formation|actin crosslink formation|bone development PLSCR1 784.780433529907 579.915769294681 989.645097765133 1.70653248310316 0.771067875770404 0.476880799096166 1 7.49346 6.33257 19.4046 5.12481 GeneID:5359,Genbank:XM_011512907.2,HGNC:HGNC:9092,MIM:604170 phospholipid scramblase 1 PLSCR3 762.086130617359 763.824781195929 760.34748003879 0.995447514609706 -0.00658284364118961 0.967328524075359 1 16.7107 15.6912 16.2254 16.5494 GeneID:57048,Genbank:NM_001201576.1,HGNC:HGNC:16495,MIM:607611 phospholipid scramblase 3 GO:0005509,GO:0005739,GO:0005886,GO:0006915,GO:0016021,GO:0017121,GO:0017124,GO:0017128,GO:0031966,GO:0042593,GO:0042632,GO:0048306,GO:0071222 calcium ion binding|mitochondrion|plasma membrane|apoptotic process|integral component of membrane|phospholipid scrambling|SH3 domain binding|phospholipid scramblase activity|mitochondrial membrane|glucose homeostasis|cholesterol homeostasis|calcium-dependent protein binding|cellular response to lipopolysaccharide PLSCR4 78.3858226652692 80.6872595327313 76.0843857978071 0.942954144661995 -0.0847404797423016 0.822250894505683 1 0.667624 0.760049 0.600007 0.6173 GeneID:57088,Genbank:NM_001177304.1,HGNC:HGNC:16497,MIM:607612 phospholipid scramblase 4 GO:0005509,GO:0005886,GO:0016021,GO:0017121,GO:0017124,GO:0017128,GO:0019899,GO:0042609,GO:0070062,GO:0071222 calcium ion binding|plasma membrane|integral component of membrane|phospholipid scrambling|SH3 domain binding|phospholipid scramblase activity|enzyme binding|CD4 receptor binding|extracellular exosome|cellular response to lipopolysaccharide PLTP 34.9272924038082 30.6049409845653 39.2496438230511 1.28246101970416 0.358914975903165 0.478844450490495 1 0.283767 0.307183 0.328113 0.3675 GeneID:5360,Genbank:NM_001242920.1,HGNC:HGNC:9093,MIM:172425 phospholipid transfer protein hsa03320,hsa04979 PPAR signaling pathway|Cholesterol metabolism PLXDC1 5.4752860601502 4.65077399104097 6.29979812925943 1.35456982889194 0.437834767256731 0.788138165330075 1 0.0275674 0.0187965 0.0390692 0.0182128 GeneID:57125,Genbank:NM_020405.4,HGNC:HGNC:20945,MIM:606826 plexin domain containing 1 GO:0001525,GO:0005576,GO:0005615,GO:0005622,GO:0005737,GO:0005886,GO:0005923,GO:0016021,GO:0021510,GO:0030425,GO:0043025,GO:0043235 angiogenesis|extracellular region|extracellular space|intracellular|cytoplasm|plasma membrane|bicellular tight junction|integral component of membrane|spinal cord development|dendrite|neuronal cell body|receptor complex PLXDC2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0025671 GeneID:84898,Genbank:XM_011519750.2,HGNC:HGNC:21013,MIM:606827 plexin domain containing 2 GO:0016021,GO:0070062 integral component of membrane|extracellular exosome PLXNA1 2044.41240250355 1882.20623237618 2206.61857263093 1.17235748913932 0.22941256051657 0.107570476182614 1 8.80475 9.07637 11.6038 10.0445 GeneID:5361,Genbank:XM_011512908.2,HGNC:HGNC:9099,MIM:601055 plexin A1 GO:0002116,GO:0004872,GO:0005886,GO:0007275,GO:0014910,GO:0016021,GO:0017154,GO:0021785,GO:0048841,GO:0060666,GO:0070062,GO:1990138 semaphorin receptor complex|receptor activity|plasma membrane|multicellular organism development|regulation of smooth muscle cell migration|integral component of membrane|semaphorin receptor activity|branchiomotor neuron axon guidance|regulation of axon extension involved in axon guidance|dichotomous subdivision of terminal units involved in salivary gland branching|extracellular exosome|neuron projection extension hsa04360 Axon guidance PLXNA2 481.477385139461 445.870595880099 517.084174398822 1.1597180419089 0.21377409071044 0.231953631904374 1 1.10363 1.17481 1.33359 1.38279 GeneID:5362,Genbank:NM_025179.3,HGNC:HGNC:9100,MIM:601054 plexin A2 GO:0001756,GO:0002116,GO:0005886,GO:0005887,GO:0017154,GO:0021785,GO:0021915,GO:0021935,GO:0030334,GO:0042802,GO:0048841,GO:0051642,GO:0060037,GO:0060174,GO:0071526 somitogenesis|semaphorin receptor complex|plasma membrane|integral component of plasma membrane|semaphorin receptor activity|branchiomotor neuron axon guidance|neural tube development|cerebellar granule cell precursor tangential migration|regulation of cell migration|identical protein binding|regulation of axon extension involved in axon guidance|centrosome localization|pharyngeal system development|limb bud formation|semaphorin-plexin signaling pathway hsa04360 Axon guidance PLXNA3 1550.54946622203 1495.48918030801 1605.60975213604 1.07363515114523 0.102503811703565 0.494995231452742 1 9.22263 9.34968 10.6016 9.4877 GeneID:55558,Genbank:NM_017514.4,HGNC:HGNC:9101,MIM:300022 plexin A3 GO:0002116,GO:0004888,GO:0005634,GO:0005886,GO:0007275,GO:0016020,GO:0016021,GO:0017154,GO:0021612,GO:0021637,GO:0021766,GO:0021785,GO:0021860,GO:0030054,GO:0043231,GO:0048841,GO:0048843,GO:0050919,GO:0051495,GO:0071526,GO:1902287,GO:1990138 semaphorin receptor complex|transmembrane signaling receptor activity|nucleus|plasma membrane|multicellular organism development|membrane|integral component of membrane|semaphorin receptor activity|facial nerve structural organization|trigeminal nerve structural organization|hippocampus development|branchiomotor neuron axon guidance|pyramidal neuron development|cell junction|intracellular membrane-bounded organelle|regulation of axon extension involved in axon guidance|negative regulation of axon extension involved in axon guidance|negative chemotaxis|positive regulation of cytoskeleton organization|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in axon guidance|neuron projection extension hsa04360 Axon guidance PLXNA4 14.6996462371846 12.4340814925659 16.9652109818034 1.36441207916697 0.448279432328064 0.560677298332513 1 0.0311995 0.0218488 0.0453434 0.0232578 GeneID:91584,Genbank:NM_020911.1,HGNC:HGNC:9102,MIM:604280 plexin A4 GO:0002116,GO:0005886,GO:0016021,GO:0017154,GO:0021612,GO:0021615,GO:0021637,GO:0021644,GO:0021784,GO:0021785,GO:0021793,GO:0021960,GO:0048485,GO:0048841,GO:0050923,GO:0071526,GO:1902287 semaphorin receptor complex|plasma membrane|integral component of membrane|semaphorin receptor activity|facial nerve structural organization|glossopharyngeal nerve morphogenesis|trigeminal nerve structural organization|vagus nerve morphogenesis|postganglionic parasympathetic fiber development|branchiomotor neuron axon guidance|chemorepulsion of branchiomotor axon|anterior commissure morphogenesis|sympathetic nervous system development|regulation of axon extension involved in axon guidance|regulation of negative chemotaxis|semaphorin-plexin signaling pathway|semaphorin-plexin signaling pathway involved in axon guidance hsa04360 Axon guidance PLXNB1 1019.89874466674 938.710594108097 1101.08689522539 1.1729780212735 0.230175981058843 0.137575832222635 1 2.83767 3.12114 3.85482 3.37653 GeneID:5364,Genbank:XM_011533835.1,HGNC:HGNC:9103,MIM:601053 plexin B1 hsa04360 Axon guidance PLXNB2 4007.71808427116 3988.72886267818 4026.70730586415 1.00952144016138 0.0136715508734855 0.952466963132627 1 19.344 21.1363 20.993 20.9532 GeneID:23654,Genbank:XM_006724413.2,HGNC:HGNC:9104,MIM:604293 plexin B2 GO:0001843,GO:0001932,GO:0005887,GO:0007156,GO:0007162,GO:0007405,GO:0007420,GO:0008360,GO:0009986,GO:0010976,GO:0017154,GO:0043087,GO:0050772,GO:0070062,GO:0071526,GO:2001222 neural tube closure|regulation of protein phosphorylation|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|negative regulation of cell adhesion|neuroblast proliferation|brain development|regulation of cell shape|cell surface|positive regulation of neuron projection development|semaphorin receptor activity|regulation of GTPase activity|positive regulation of axonogenesis|extracellular exosome|semaphorin-plexin signaling pathway|regulation of neuron migration hsa04360 Axon guidance PLXNB3 755.475584420808 723.024393319629 787.926775521987 1.08976513490004 0.124017240299949 0.502272957802272 1 4.88039 4.44006 4.61337 5.52444 GeneID:5365,Genbank:NM_001163257.1,HGNC:HGNC:9105,MIM:300214 plexin B3 GO:0001938,GO:0005886,GO:0007156,GO:0007162,GO:0008360,GO:0009986,GO:0010593,GO:0010976,GO:0016021,GO:0017154,GO:0019904,GO:0030336,GO:0034260,GO:0048675,GO:0050772,GO:0050918,GO:0051022,GO:0060326,GO:0071526,GO:0098632 positive regulation of endothelial cell proliferation|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|negative regulation of cell adhesion|regulation of cell shape|cell surface|negative regulation of lamellipodium assembly|positive regulation of neuron projection development|integral component of membrane|semaphorin receptor activity|protein domain specific binding|negative regulation of cell migration|negative regulation of GTPase activity|axon extension|positive regulation of axonogenesis|positive chemotaxis|Rho GDP-dissociation inhibitor binding|cell chemotaxis|semaphorin-plexin signaling pathway|cell-cell adhesion mediator activity hsa04360 Axon guidance PLXNC1 6.17367804522178 7.98522125537262 4.36213483507094 0.546276013596493 -0.87229801767813 0.495658995752279 1 0.00385568 0.0435728 0.0184457 0.0137514 GeneID:10154,Genbank:NM_005761.2,HGNC:HGNC:9106,MIM:604259 plexin C1 GO:0005102,GO:0005886,GO:0007155,GO:0007162,GO:0008360,GO:0016020,GO:0016021,GO:0017154,GO:0043087,GO:0050772 receptor binding|plasma membrane|cell adhesion|negative regulation of cell adhesion|regulation of cell shape|membrane|integral component of membrane|semaphorin receptor activity|regulation of GTPase activity|positive regulation of axonogenesis hsa04360 Axon guidance PLXND1 5220.12901774545 5144.2556198544 5296.00241563651 1.0294983000449 0.0419414477275018 0.769647821928031 1 25.416 26.2115 27.91 26.1194 GeneID:23129,Genbank:NM_015103.2,HGNC:HGNC:9107,MIM:604282 plexin D1 GO:0001525,GO:0001569,GO:0003151,GO:0003279,GO:0005886,GO:0005887,GO:0007162,GO:0007221,GO:0007416,GO:0008360,GO:0017154,GO:0019904,GO:0030027,GO:0030334,GO:0031258,GO:0032092,GO:0035904,GO:0043087,GO:0043542,GO:0045765,GO:0050772,GO:0060666,GO:0060976,GO:0071526 angiogenesis|branching involved in blood vessel morphogenesis|outflow tract morphogenesis|cardiac septum development|plasma membrane|integral component of plasma membrane|negative regulation of cell adhesion|positive regulation of transcription of Notch receptor target|synapse assembly|regulation of cell shape|semaphorin receptor activity|protein domain specific binding|lamellipodium|regulation of cell migration|lamellipodium membrane|positive regulation of protein binding|aorta development|regulation of GTPase activity|endothelial cell migration|regulation of angiogenesis|positive regulation of axonogenesis|dichotomous subdivision of terminal units involved in salivary gland branching|coronary vasculature development|semaphorin-plexin signaling pathway PM20D2 889.26160724854 911.937946443219 866.585268053861 0.95026780213912 -0.0735939473681256 0.652696537358376 1 4.87704 4.56751 4.95614 3.92787 GeneID:135293,Genbank:XM_011535481.3,HGNC:HGNC:21408,MIM:615913 peptidase M20 domain containing 2 GO:0005654,GO:0006508,GO:0016805,GO:0032268,GO:0070062 nucleoplasm|proteolysis|dipeptidase activity|regulation of cellular protein metabolic process|extracellular exosome PMAIP1 966.323609419143 1212.04663053388 720.600588304404 0.594532066795973 -0.7501734693405 0.000464459700720839 0.0595102925339596 35.718 31.0313 18.8228 20.6426 GeneID:5366,Genbank:NM_021127.2,HGNC:HGNC:9108,MIM:604959 phorbol-12-myristate-13-acetate-induced protein 1 GO:0001836,GO:0001844,GO:0005634,GO:0005739,GO:0005741,GO:0005829,GO:0006915,GO:0006919,GO:0006974,GO:0010498,GO:0010907,GO:0010917,GO:0032461,GO:0042149,GO:0042981,GO:0043029,GO:0043065,GO:0043280,GO:0043331,GO:0043517,GO:0046902,GO:0051607,GO:0071456,GO:0072332,GO:0072593,GO:0090200,GO:0097193,GO:1900740,GO:1902043,GO:1902237,GO:2001244 release of cytochrome c from mitochondria|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|nucleus|mitochondrion|mitochondrial outer membrane|cytosol|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|proteasomal protein catabolic process|positive regulation of glucose metabolic process|negative regulation of mitochondrial membrane potential|positive regulation of protein oligomerization|cellular response to glucose starvation|regulation of apoptotic process|T cell homeostasis|positive regulation of apoptotic process|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|response to dsRNA|positive regulation of DNA damage response, signal transduction by p53 class mediator|regulation of mitochondrial membrane permeability|defense response to virus|cellular response to hypoxia|intrinsic apoptotic signaling pathway by p53 class mediator|reactive oxygen species metabolic process|positive regulation of release of cytochrome c from mitochondria|intrinsic apoptotic signaling pathway|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of intrinsic apoptotic signaling pathway hsa01524,hsa04115,hsa04210,hsa04215,hsa05200,hsa05203,hsa05210 Platinum drug resistance|p53 signaling pathway|Apoptosis|Apoptosis - multiple species|Pathways in cancer|Viral carcinogenesis|Colorectal cancer PMCH 10.0944468045131 17.767031984304 2.42186162472226 0.136312110366088 -2.87501435380834 0.0205452507095182 0.586657016555258 0.149933 0.110153 0.0133157 0.0247545 GeneID:5367,Genbank:NM_002674.3,HGNC:HGNC:9109,MIM:176795 pro-melanin concentrating hormone GO:0005576,GO:0005634,GO:0007186,GO:0007218,GO:0007268,GO:0007275,GO:0007283,GO:0007631,GO:0030154,GO:0030354 extracellular region|nucleus|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|multicellular organism development|spermatogenesis|feeding behavior|cell differentiation|melanin-concentrating hormone activity PMEL 9.44614434624895 8.71542403075469 10.1768646617432 1.16768439789406 0.223650394834982 0.868284731917251 1 0.143742 0.1654 0.15429 0.125669 GeneID:6490,Genbank:NM_006928.4,HGNC:HGNC:10880,MIM:155550 premelanosome protein GO:0005576,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0032438,GO:0032585,GO:0042438,GO:0042470,GO:0042802,GO:0048066 extracellular region|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|melanosome organization|multivesicular body membrane|melanin biosynthetic process|melanosome|identical protein binding|developmental pigmentation PMEPA1 6763.25862752726 7026.28798608777 6500.22926896676 0.92512992377161 -0.11227210523845 0.494732671003321 1 62.5847 57.2257 51.9141 60.1498 GeneID:56937,Genbank:NM_199171.2,HGNC:HGNC:14107,MIM:606564 prostate transmembrane protein, androgen induced 1 GO:0000139,GO:0005886,GO:0010008,GO:0010991,GO:0016021,GO:0030512,GO:0030521,GO:0031901,GO:0043231,GO:0050699,GO:0060394,GO:0070412 Golgi membrane|plasma membrane|endosome membrane|negative regulation of SMAD protein complex assembly|integral component of membrane|negative regulation of transforming growth factor beta receptor signaling pathway|androgen receptor signaling pathway|early endosome membrane|intracellular membrane-bounded organelle|WW domain binding|negative regulation of pathway-restricted SMAD protein phosphorylation|R-SMAD binding PMF1 441.472805556944 462.321301137694 420.624309976193 0.909809495995768 -0.136363602273065 0.441711422580464 1 38.6262 42.0503 35.8947 40.0493 GeneID:11243,Genbank:NM_001199654.1,HGNC:HGNC:9112,MIM:609176 polyamine modulated factor 1 GO:0000444,GO:0000777,GO:0003713,GO:0005654,GO:0005667,GO:0005794,GO:0005829,GO:0006355,GO:0006366,GO:0007059,GO:0007062,GO:0043231,GO:0043522,GO:0051301 MIS12/MIND type complex|condensed chromosome kinetochore|transcription coactivator activity|nucleoplasm|transcription factor complex|Golgi apparatus|cytosol|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|chromosome segregation|sister chromatid cohesion|intracellular membrane-bounded organelle|leucine zipper domain binding|cell division PMFBP1 6.18137692637358 5.09281911831339 7.26993473443377 1.42748732392471 0.51347793452531 0.726579880182898 1 0.0185131 0.0230523 0.0468736 0.0218417 GeneID:83449,Genbank:XM_011523361.3,HGNC:HGNC:17728 polyamine modulated factor 1 binding protein 1 GO:0005737 cytoplasm PML 2004.64714663757 1807.1323063299 2202.16198694524 1.21859477539727 0.285218460071011 0.494964005845354 1 8.09612 9.71089 14.1653 8.1154 GeneID:5371,Genbank:NM_033238.2,HGNC:HGNC:9113,MIM:102578 promyelocytic leukemia hsa04120,hsa04144,hsa05164,hsa05168,hsa05200,hsa05202,hsa05221 Ubiquitin mediated proteolysis|Endocytosis|Influenza A|Herpes simplex infection|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia PMM1 737.02945203702 712.791745809172 761.267158264867 1.06800781959205 0.0949222099893043 0.686000027024699 1 14.6182 15.6899 15.0887 18.6573 GeneID:5372,Genbank:NM_002676.2,HGNC:HGNC:9114,MIM:601786 phosphomannomutase 1 GO:0004615,GO:0005829,GO:0006013,GO:0006487,GO:0009298,GO:0043025,GO:0045047,GO:0046872,GO:1990830 phosphomannomutase activity|cytosol|mannose metabolic process|protein N-linked glycosylation|GDP-mannose biosynthetic process|neuronal cell body|protein targeting to ER|metal ion binding|cellular response to leukemia inhibitory factor hsa00051,hsa00520 Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism PMM2 942.659880917098 980.018636694861 905.301125139334 0.923759091145947 -0.114411437320986 0.463750906088054 1 15.7019 15.5472 15.1703 14.0995 GeneID:5373,Genbank:NM_000303.2,HGNC:HGNC:9115,MIM:601785 phosphomannomutase 2 GO:0004615,GO:0005634,GO:0005829,GO:0006013,GO:0006486,GO:0006487,GO:0009298,GO:0043025,GO:0045047,GO:0070062 phosphomannomutase activity|nucleus|cytosol|mannose metabolic process|protein glycosylation|protein N-linked glycosylation|GDP-mannose biosynthetic process|neuronal cell body|protein targeting to ER|extracellular exosome hsa00051,hsa00520 Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism PMP22 8955.9756403926 8403.68485218344 9508.26642860176 1.13144014748856 0.178160268912972 0.172130635966394 1 160.868 162.884 188.346 184.164 GeneID:5376,Genbank:NM_001281456.1,HGNC:HGNC:9118,MIM:601097 peripheral myelin protein 22 PMPCA 1861.17821725024 1877.39176225087 1844.96467224961 0.982727584805003 -0.0251365425310127 0.845048152254424 1 18.6772 19.9168 20.217 19.0954 GeneID:23203,Genbank:NM_015160.2,HGNC:HGNC:18667,MIM:613036 peptidase, mitochondrial processing alpha subunit GO:0004222,GO:0005615,GO:0005739,GO:0005743,GO:0005759,GO:0006508,GO:0006627,GO:0006851,GO:0008270 metalloendopeptidase activity|extracellular space|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|proteolysis|protein processing involved in protein targeting to mitochondrion|mitochondrial calcium ion transmembrane transport|zinc ion binding PMPCB 2207.92580838549 2245.77324169191 2170.07837507906 0.966294519318512 -0.0494651161779914 0.722572374282165 1 17.298 18.5933 17.1786 17.9943 GeneID:9512,Genbank:NM_004279.2,HGNC:HGNC:9119,MIM:603131 peptidase, mitochondrial processing beta subunit GO:0004222,GO:0005739,GO:0005743,GO:0005750,GO:0005759,GO:0006122,GO:0006627,GO:0006851,GO:0008270,GO:0009060,GO:0016485 metalloendopeptidase activity|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial matrix|mitochondrial electron transport, ubiquinol to cytochrome c|protein processing involved in protein targeting to mitochondrion|mitochondrial calcium ion transmembrane transport|zinc ion binding|aerobic respiration|protein processing PMS1 125.580058917795 129.99134903083 121.168768804759 0.932129481755134 -0.101397721862881 0.726833583440797 1 0.709168 0.657729 0.636634 0.565689 GeneID:5378,Genbank:NM_001321047.1,HGNC:HGNC:9121,MIM:600258 PMS1 homolog 1, mismatch repair system component PMS2 588.019933094003 578.984669766306 597.0551964217 1.03121071696542 0.044339162249483 0.798355690969635 1 2.81762 2.83861 2.79752 2.84481 GeneID:5395,Genbank:NM_001322008.1,HGNC:HGNC:9122,MIM:600259 PMS1 homolog 2, mismatch repair system component hsa03430,hsa03460 Mismatch repair|Fanconi anemia pathway PMVK 1080.65789450718 976.984189735456 1184.3315992789 1.21223210336658 0.277665954847976 0.191111726360503 1 18.0122 23.1485 23.3251 27.1269 GeneID:10654,Genbank:NM_001323012.2,HGNC:HGNC:9141,MIM:607622 phosphomevalonate kinase GO:0004631,GO:0005524,GO:0005777,GO:0005829,GO:0006695,GO:0016020,GO:0016126,GO:0019287,GO:0045540,GO:0070062,GO:0070723 phosphomevalonate kinase activity|ATP binding|peroxisome|cytosol|cholesterol biosynthetic process|membrane|sterol biosynthetic process|isopentenyl diphosphate biosynthetic process, mevalonate pathway|regulation of cholesterol biosynthetic process|extracellular exosome|response to cholesterol hsa00900,hsa04146 Terpenoid backbone biosynthesis|Peroxisome PNCK 5.50636886052126 6.169014471598 4.84372324944452 0.785169701213202 -0.34892359293509 0.85390637906809 1 0.100917 0.0730418 0 0.0583285 GeneID:139728,Genbank:XM_011531107.2,HGNC:HGNC:13415,MIM:300680 pregnancy up-regulated nonubiquitous CaM kinase GO:0004683,GO:0005516,GO:0005524,GO:0005622,GO:0005634,GO:0005737,GO:0018105,GO:0018107,GO:0035556 calmodulin-dependent protein kinase activity|calmodulin binding|ATP binding|intracellular|nucleus|cytoplasm|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|intracellular signal transduction PNISR 705.131107961172 748.198297261377 662.063918660968 0.88487760675788 -0.176450174533066 0.507713507078247 1 2.6748 2.0772 2.18696 1.81003 GeneID:25957,Genbank:NM_001322408.1,HGNC:HGNC:21222,MIM:616653 PNN interacting serine and arginine rich protein GO:0003723,GO:0005829,GO:0016607 RNA binding|cytosol|nuclear speck PNKD 937.315824344137 961.147000392803 913.484648295472 0.950410965151166 -0.0733766138855179 0.632169660746434 1 10.5247 10.4915 9.91084 10.5223 GeneID:25953,Genbank:NM_015488.4,HGNC:HGNC:9153,MIM:609023 paroxysmal nonkinesigenic dyskinesia GO:0004416,GO:0005634,GO:0005739,GO:0016020,GO:0019243,GO:0032225,GO:0042053,GO:0046872,GO:0046929,GO:0050884 hydroxyacylglutathione hydrolase activity|nucleus|mitochondrion|membrane|methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione|regulation of synaptic transmission, dopaminergic|regulation of dopamine metabolic process|metal ion binding|negative regulation of neurotransmitter secretion|neuromuscular process controlling posture PNKP 847.903212302771 815.772349803409 880.034074802132 1.07877409060776 0.109392777260342 0.508124727123497 1 14.9101 16.9451 16.1467 18.7036 GeneID:11284,Genbank:NM_007254.3,HGNC:HGNC:9154,MIM:605610 polynucleotide kinase 3'-phosphatase PNLDC1 1.45683648539321 0.490071401957362 2.42360156882906 4.94540501475725 2.30608867848779 0.553970604158029 1 0 0.0135178 0.013882 0 GeneID:154197,Genbank:XM_024446339.1,HGNC:HGNC:21185 PARN like, ribonuclease domain containing 1 GO:0000184,GO:0000289,GO:0003723,GO:0004535,GO:0005783,GO:0005789,GO:0016021,GO:0046872 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|poly(A)-specific ribonuclease activity|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|metal ion binding hsa03018 RNA degradation PNLIP 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0261654 0 GeneID:5406,Genbank:NM_000936.3,HGNC:HGNC:9155,MIM:246600 pancreatic lipase hsa00561,hsa04972,hsa04975,hsa04977 Glycerolipid metabolism|Pancreatic secretion|Fat digestion and absorption|Vitamin digestion and absorption PNLIPRP3 1.75740311011212 2.54640955915669 0.968396661067546 0.380298863387967 -1.39479446774372 0.672338801468317 1 0.0336555 0.0489052 0 0.0151333 GeneID:119548,Genbank:XM_011539276.1,HGNC:HGNC:23492 pancreatic lipase related protein 3 GO:0004806,GO:0005576,GO:0016042 triglyceride lipase activity|extracellular region|lipid catabolic process hsa00561 Glycerolipid metabolism PNMA1 1127.46244670189 1095.70287952041 1159.22201388337 1.05797113026732 0.0813002599770443 0.595898030464822 1 20.6051 21.1866 22.8238 22.183 GeneID:9240,Genbank:NM_006029.4,HGNC:HGNC:9158,MIM:604010 PNMA family member 1 GO:0002437,GO:0005730,GO:0005737,GO:0043065 inflammatory response to antigenic stimulus|nucleolus|cytoplasm|positive regulation of apoptotic process PNMA2 1910.91156077419 1990.40208300086 1831.42103854751 0.920126166561453 -0.12009639959511 0.398834035189037 1 16.7076 16.3418 15.8588 14.8706 GeneID:10687,Genbank:NM_007257.5,HGNC:HGNC:9159,MIM:603970 PNMA family member 2 GO:0005730,GO:0043065 nucleolus|positive regulation of apoptotic process PNMA6A 7.9464789176375 4.74682654041085 11.1461312948641 2.34812272999118 1.23150781616615 0.23842405411711 1 0.169373 0.0411168 0.24519 0.250188 GeneID:84968,Genbank:NM_032882.5,HGNC:HGNC:28248,MIM:300917 PNMA family member 6A PNMA8A 369.927737442199 383.652162142585 356.203312741813 0.928453812830147 -0.107097951725342 0.551787221424529 1 3.20868 3.7512 3.22786 3.07692 GeneID:55228,Genbank:NM_001103149.1,HGNC:HGNC:25578 PNMA family member 8A PNN 857.630022442126 1013.91777332247 701.342271561781 0.691715137080177 -0.531750067044555 0.0236271893193866 0.618322000227609 10.1778 8.85345 7.75404 5.57279 GeneID:5411,Genbank:NM_002687.3,HGNC:HGNC:9162,MIM:603154 pinin, desmosome associated protein GO:0000398,GO:0003677,GO:0003723,GO:0005198,GO:0005882,GO:0005886,GO:0005911,GO:0006351,GO:0006355,GO:0007155,GO:0016020,GO:0016607,GO:0030057,GO:0071013 mRNA splicing, via spliceosome|DNA binding|RNA binding|structural molecule activity|intermediate filament|plasma membrane|cell-cell junction|transcription, DNA-templated|regulation of transcription, DNA-templated|cell adhesion|membrane|nuclear speck|desmosome|catalytic step 2 spliceosome hsa03013,hsa03015 RNA transport|mRNA surveillance pathway PNO1 989.298657802218 1157.1921274834 821.405188121036 0.709826111509576 -0.494462448845098 0.00112765929047616 0.110125556074793 12.9508 15.482 9.89732 10.544 GeneID:56902,Genbank:NM_020143.3,HGNC:HGNC:32790 partner of NOB1 homolog GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006364 RNA binding|nucleus|nucleoplasm|nucleolus|cytosol|rRNA processing PNP 1291.78675501065 1437.49705874277 1146.07645127852 0.79727220609472 -0.32685571905884 0.0264063068825854 0.649651937068338 25.173 25.4771 19.5592 21.4393 GeneID:4860,Genbank:NM_000270.3,HGNC:HGNC:7892,MIM:164050 purine nucleoside phosphorylase hsa00230,hsa00240,hsa00760 Purine metabolism|Pyrimidine metabolism|Nicotinate and nicotinamide metabolism PNPLA1 1.21473732012632 0.490071401957362 1.93940323829528 3.95738912850095 1.98454893191584 0.683483673443307 1 0 0.00567681 0.0176768 0 GeneID:285848,Genbank:XM_017010778.1,HGNC:HGNC:21246,MIM:612121 patatin like phospholipase domain containing 1 GO:0004806,GO:0005737,GO:0005811,GO:0016020,GO:0019433,GO:0055088 triglyceride lipase activity|cytoplasm|lipid droplet|membrane|triglyceride catabolic process|lipid homeostasis PNPLA2 1334.79843687922 1486.67872072874 1182.91815302971 0.795678404847188 -0.329742650904005 0.0544567065837349 0.850412673568737 24.3638 26.7466 20.2266 21.7154 GeneID:57104,Genbank:XM_024448618.1,HGNC:HGNC:30802,MIM:609059 patatin like phospholipase domain containing 2 GO:0004465,GO:0004806,GO:0005654,GO:0005737,GO:0005788,GO:0005789,GO:0005811,GO:0005829,GO:0005886,GO:0010891,GO:0010898,GO:0016020,GO:0016021,GO:0016411,GO:0019433,GO:0019915,GO:0034389,GO:0036155,GO:0043687,GO:0044267,GO:0055088 lipoprotein lipase activity|triglyceride lipase activity|nucleoplasm|cytoplasm|endoplasmic reticulum lumen|endoplasmic reticulum membrane|lipid droplet|cytosol|plasma membrane|negative regulation of sequestering of triglyceride|positive regulation of triglyceride catabolic process|membrane|integral component of membrane|acylglycerol O-acyltransferase activity|triglyceride catabolic process|lipid storage|lipid particle organization|acylglycerol acyl-chain remodeling|post-translational protein modification|cellular protein metabolic process|lipid homeostasis hsa00561,hsa04714,hsa04923 Glycerolipid metabolism|Thermogenesis|Regulation of lipolysis in adipocytes PNPLA3 11.2343036371805 12.2900026685111 10.17860460585 0.82820198501089 -0.271945434365111 0.793884861376013 1 0.163503 0.180267 0.170809 0.111613 GeneID:80339,Genbank:NM_025225.2,HGNC:HGNC:18590,MIM:609567 patatin like phospholipase domain containing 3 GO:0001676,GO:0004465,GO:0004623,GO:0004806,GO:0005737,GO:0005789,GO:0005811,GO:0006650,GO:0006654,GO:0016020,GO:0016021,GO:0016411,GO:0019432,GO:0019433,GO:0034389,GO:0035727,GO:0036042,GO:0036153,GO:0036155,GO:0042171,GO:0051264,GO:0051265,GO:0055088 long-chain fatty acid metabolic process|lipoprotein lipase activity|phospholipase A2 activity|triglyceride lipase activity|cytoplasm|endoplasmic reticulum membrane|lipid droplet|glycerophospholipid metabolic process|phosphatidic acid biosynthetic process|membrane|integral component of membrane|acylglycerol O-acyltransferase activity|triglyceride biosynthetic process|triglyceride catabolic process|lipid particle organization|lysophosphatidic acid binding|long-chain fatty acyl-CoA binding|triglyceride acyl-chain remodeling|acylglycerol acyl-chain remodeling|lysophosphatidic acid acyltransferase activity|mono-olein transacylation activity|diolein transacylation activity|lipid homeostasis hsa00561 Glycerolipid metabolism PNPLA6 4202.76293981294 3970.14436702338 4435.3815126025 1.11718393654484 0.159866735055505 0.24746172404564 1 33.1759 35.5593 40.4348 37.5012 GeneID:10908,Genbank:NM_006702.4,HGNC:HGNC:16268,MIM:603197 patatin like phospholipase domain containing 6 GO:0004622,GO:0005783,GO:0005789,GO:0016020,GO:0016021,GO:0032502,GO:0046470,GO:0046475 lysophospholipase activity|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|integral component of membrane|developmental process|phosphatidylcholine metabolic process|glycerophospholipid catabolic process hsa00564 Glycerophospholipid metabolism PNPLA7 16.1329045712621 12.8761266198383 19.3896825226858 1.50586298932569 0.590590512631131 0.417568832664191 1 0.0995259 0.0597174 0.137739 0.0343245 GeneID:375775,Genbank:XM_017014709.1,HGNC:HGNC:24768,MIM:612122 patatin like phospholipase domain containing 7 GO:0004622,GO:0005765,GO:0005783,GO:0016021,GO:0016042,GO:0031965,GO:0031966,GO:0032502 lysophospholipase activity|lysosomal membrane|endoplasmic reticulum|integral component of membrane|lipid catabolic process|nuclear membrane|mitochondrial membrane|developmental process hsa00564 Glycerophospholipid metabolism PNPLA8 593.799566460277 626.375482930406 561.223649990147 0.895985978513311 -0.158451939487957 0.36569319912762 1 4.35199 3.96576 4.01327 3.57233 GeneID:50640,Genbank:NM_001256011.2,HGNC:HGNC:28900,MIM:612123 patatin like phospholipase domain containing 8 GO:0000139,GO:0001516,GO:0004622,GO:0004623,GO:0005524,GO:0005622,GO:0005777,GO:0005778,GO:0005789,GO:0006631,GO:0008219,GO:0016020,GO:0016021,GO:0019369,GO:0034638,GO:0036151,GO:0036152,GO:0043651,GO:0046338,GO:0047499,GO:0048471,GO:0050482 Golgi membrane|prostaglandin biosynthetic process|lysophospholipase activity|phospholipase A2 activity|ATP binding|intracellular|peroxisome|peroxisomal membrane|endoplasmic reticulum membrane|fatty acid metabolic process|cell death|membrane|integral component of membrane|arachidonic acid metabolic process|phosphatidylcholine catabolic process|phosphatidylcholine acyl-chain remodeling|phosphatidylethanolamine acyl-chain remodeling|linoleic acid metabolic process|phosphatidylethanolamine catabolic process|calcium-independent phospholipase A2 activity|perinuclear region of cytoplasm|arachidonic acid secretion PNPO 1264.83725990873 1335.05556942603 1194.61895039143 0.894808409289674 -0.16034928017171 0.270745416574121 1 13.995 14.8057 13.5453 12.7349 GeneID:55163,Genbank:NM_018129.3,HGNC:HGNC:30260,MIM:603287 pyridoxamine 5'-phosphate oxidase GO:0004733,GO:0005654,GO:0005829,GO:0008615,GO:0010181,GO:0030170,GO:0042803,GO:0042816,GO:0042823,GO:0070062 pyridoxamine-phosphate oxidase activity|nucleoplasm|cytosol|pyridoxine biosynthetic process|FMN binding|pyridoxal phosphate binding|protein homodimerization activity|vitamin B6 metabolic process|pyridoxal phosphate biosynthetic process|extracellular exosome hsa00750 Vitamin B6 metabolism PNPT1 606.721790417058 579.809908090203 633.633672743912 1.09283001877459 0.128069018446374 0.824826495900488 1 4.47979 4.0501 6.71186 2.7396 GeneID:87178,Genbank:NM_033109.4,HGNC:HGNC:23166,MIM:610316 polyribonucleotide nucleotidyltransferase 1 GO:0000175,GO:0000957,GO:0000958,GO:0000962,GO:0000964,GO:0000965,GO:0003723,GO:0004654,GO:0005634,GO:0005737,GO:0005739,GO:0005758,GO:0005789,GO:0005829,GO:0006401,GO:0006402,GO:0008266,GO:0034046,GO:0034599,GO:0035198,GO:0035458,GO:0035927,GO:0035928,GO:0042788,GO:0043457,GO:0043631,GO:0045025,GO:0045926,GO:0051260,GO:0051591,GO:0060416,GO:0061014,GO:0070207,GO:0070584,GO:0071042,GO:0071850,GO:0097222,GO:0097421,GO:2000627,GO:2000772 3'-5'-exoribonuclease activity|mitochondrial RNA catabolic process|mitochondrial mRNA catabolic process|positive regulation of mitochondrial RNA catabolic process|mitochondrial RNA 5'-end processing|mitochondrial RNA 3'-end processing|RNA binding|polyribonucleotide nucleotidyltransferase activity|nucleus|cytoplasm|mitochondrion|mitochondrial intermembrane space|endoplasmic reticulum membrane|cytosol|RNA catabolic process|mRNA catabolic process|poly(U) RNA binding|poly(G) binding|cellular response to oxidative stress|miRNA binding|cellular response to interferon-beta|RNA import into mitochondrion|rRNA import into mitochondrion|polysomal ribosome|regulation of cellular respiration|RNA polyadenylation|mitochondrial degradosome|negative regulation of growth|protein homooligomerization|response to cAMP|response to growth hormone|positive regulation of mRNA catabolic process|protein homotrimerization|mitochondrion morphogenesis|nuclear polyadenylation-dependent mRNA catabolic process|mitotic cell cycle arrest|mitochondrial mRNA polyadenylation|liver regeneration|positive regulation of miRNA catabolic process|regulation of cellular senescence hsa00230,hsa00240,hsa03018 Purine metabolism|Pyrimidine metabolism|RNA degradation PNRC1 393.782838254015 349.943096612005 437.622579896026 1.25055354465596 0.322566830374402 0.0833179184625414 0.963076417285947 8.62649 9.22978 11.4386 10.6464 GeneID:10957,Genbank:NM_006813.2,HGNC:HGNC:17278,MIM:606714 proline rich nuclear receptor coactivator 1 GO:0000184,GO:0000932,GO:0005634,GO:0006351,GO:0006355,GO:0031087 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|P-body|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|deadenylation-independent decapping of nuclear-transcribed mRNA PNRC2 974.718303692717 1128.9580572669 820.478550118531 0.72675733596767 -0.460454365731543 0.00295705053748171 0.204138454346151 19.641 18.0621 14.1794 13.2437 GeneID:55629,Genbank:XM_017001691.1,HGNC:HGNC:23158,MIM:611882 proline rich nuclear receptor coactivator 2 GO:0000184,GO:0000932,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006351,GO:0006355,GO:0031087 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|P-body|nucleus|nucleoplasm|Golgi apparatus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|deadenylation-independent decapping of nuclear-transcribed mRNA POC1A 1451.18032108846 1382.12204132416 1520.23860085275 1.09993079872764 0.137412760592704 0.365479677603723 1 11.6237 13.3385 13.6197 13.8502 GeneID:25886,Genbank:NM_001161580.1,HGNC:HGNC:24488,MIM:614783 POC1 centriolar protein A GO:0000922,GO:0003431,GO:0005813,GO:0005814,GO:0007052,GO:0007283,GO:0010825,GO:0036064,GO:1905515 spindle pole|growth plate cartilage chondrocyte development|centrosome|centriole|mitotic spindle organization|spermatogenesis|positive regulation of centrosome duplication|ciliary basal body|non-motile cilium assembly POC1B 292.213370606374 333.357104184609 251.06963702814 0.753155201663561 -0.40898090515816 0.0776402281759307 0.94157495521624 3.93672 3.19693 3.27412 2.38007 GeneID:282809,Genbank:NM_172240.2,HGNC:HGNC:30836,MIM:614784 POC1 centriolar protein B GO:0000922,GO:0001895,GO:0005813,GO:0005814,GO:0008283,GO:0036064,GO:0060271 spindle pole|retina homeostasis|centrosome|centriole|cell proliferation|ciliary basal body|cilium assembly POC5 202.872285268585 206.565932249163 199.178638288007 0.964237597745568 -0.0525394102024048 0.83614591054302 1 2.36056 2.20135 1.90447 2.27946 GeneID:134359,Genbank:XM_011543158.2,HGNC:HGNC:26658,MIM:617880 POC5 centriolar protein GO:0005634,GO:0005654,GO:0005813,GO:0005814,GO:0005829,GO:0007049 nucleus|nucleoplasm|centrosome|centriole|cytosol|cell cycle PODNL1 13.3645166107944 11.2138073152264 15.5152259063623 1.3835823525606 0.46840851752565 0.644277393103941 1 0.0924614 0.0778358 0.253199 0.0792039 GeneID:79883,Genbank:NM_001146255.1,HGNC:HGNC:26275 podocan like 1 GO:0004860,GO:0005578,GO:0005737,GO:0006469,GO:0019221,GO:0046426 protein kinase inhibitor activity|proteinaceous extracellular matrix|cytoplasm|negative regulation of protein kinase activity|cytokine-mediated signaling pathway|negative regulation of JAK-STAT cascade PODXL 1892.08210663402 1560.6274081462 2223.53680512185 1.4247710847031 0.510730142791114 0.000307737557009015 0.0465903515773397 8.5601 8.35183 12.9418 11.7001 GeneID:5420,Genbank:NM_005397.3,HGNC:HGNC:9171,MIM:602632 podocalyxin like GO:0001726,GO:0005615,GO:0005730,GO:0005737,GO:0005815,GO:0005886,GO:0005887,GO:0007155,GO:0007162,GO:0016324,GO:0016477,GO:0022408,GO:0030027,GO:0030175,GO:0030335,GO:0031528,GO:0032534,GO:0033634,GO:0036057,GO:0043231,GO:0045121,GO:0070062,GO:0072015,GO:0072175 ruffle|extracellular space|nucleolus|cytoplasm|microtubule organizing center|plasma membrane|integral component of plasma membrane|cell adhesion|negative regulation of cell adhesion|apical plasma membrane|cell migration|negative regulation of cell-cell adhesion|lamellipodium|filopodium|positive regulation of cell migration|microvillus membrane|regulation of microvillus assembly|positive regulation of cell-cell adhesion mediated by integrin|slit diaphragm|intracellular membrane-bounded organelle|membrane raft|extracellular exosome|glomerular visceral epithelial cell development|epithelial tube formation PODXL2 327.555000809533 293.115448296022 361.994553323044 1.23498967873389 0.304498984723591 0.126607190264243 1 4.33451 5.10466 5.62783 6.21114 GeneID:50512,Genbank:NM_015720.3,HGNC:HGNC:17936,MIM:616627 podocalyxin like 2 GO:0005539,GO:0005796,GO:0005887,GO:0050427,GO:0050901 glycosaminoglycan binding|Golgi lumen|integral component of plasma membrane|3'-phosphoadenosine 5'-phosphosulfate metabolic process|leukocyte tethering or rolling POFUT1 4077.18735704093 3898.83000570761 4255.54470837424 1.09149275606898 0.126302555598485 0.345774931101605 1 25.8673 26.055 29.8229 28.1674 GeneID:23509,Genbank:NM_015352.1,HGNC:HGNC:14988,MIM:607491 protein O-fucosyltransferase 1 hsa00514 Other types of O-glycan biosynthesis POFUT2 1307.9180895416 1159.04756888761 1456.7886101956 1.25688422917254 0.329851770131874 0.0281315753436712 0.668561867500627 5.71401 6.87713 7.74863 7.79879 GeneID:23275,Genbank:NM_133635.5,HGNC:HGNC:14683,MIM:610249 protein O-fucosyltransferase 2 hsa00514 Other types of O-glycan biosynthesis POGK 2209.66990837466 2255.40116494168 2163.93865180763 0.959447341539163 -0.0597244673984937 0.670665845456681 1 9.53474 9.74516 9.96372 8.82734 GeneID:57645,Genbank:NM_017542.4,HGNC:HGNC:18800 pogo transposable element derived with KRAB domain GO:0003677,GO:0005634,GO:0006355,GO:0007275 DNA binding|nucleus|regulation of transcription, DNA-templated|multicellular organism development POGLUT1 278.910447119895 309.680806412347 248.140087827442 0.801276936411221 -0.319627143469635 0.12016089447882 1 2.21544 2.21404 2.05449 1.73245 GeneID:56983,Genbank:NM_152305.2,HGNC:HGNC:22954,MIM:615618 protein O-glucosyltransferase 1 GO:0001756,GO:0005788,GO:0006493,GO:0006664,GO:0007369,GO:0010470,GO:0018242,GO:0030158,GO:0035251,GO:0035252,GO:0045747,GO:0046527,GO:0048318,GO:0048339,GO:0060537,GO:0070062,GO:0072358 somitogenesis|endoplasmic reticulum lumen|protein O-linked glycosylation|glycolipid metabolic process|gastrulation|regulation of gastrulation|protein O-linked glycosylation via serine|protein xylosyltransferase activity|UDP-glucosyltransferase activity|UDP-xylosyltransferase activity|positive regulation of Notch signaling pathway|glucosyltransferase activity|axial mesoderm development|paraxial mesoderm development|muscle tissue development|extracellular exosome|cardiovascular system development hsa00514 Other types of O-glycan biosynthesis POGZ 1599.36779972413 1574.18469426588 1624.55090518238 1.03199510902372 0.0454361333542384 0.73921317755277 1 3.27006 3.10004 3.5498 2.99071 GeneID:23126,Genbank:NM_001194938.1,HGNC:HGNC:18801,MIM:614787 pogo transposable element derived with ZNF domain GO:0000790,GO:0003677,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007064,GO:0046872,GO:0051301,GO:0051382 nuclear chromatin|DNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|mitotic sister chromatid cohesion|metal ion binding|cell division|kinetochore assembly POLA1 512.422502629513 539.19283365839 485.652171600636 0.900702200186001 -0.150877909305994 0.431705147241012 1 1.85144 1.65071 1.81282 1.38627 GeneID:5422,Genbank:NM_001330360.1,HGNC:HGNC:9173,MIM:312040 DNA polymerase alpha 1, catalytic subunit hsa00230,hsa00240,hsa03030 Purine metabolism|Pyrimidine metabolism|DNA replication POLA2 1203.89270365206 1159.77675466213 1248.00865264199 1.07607662218197 0.105780808848309 0.492391524570781 1 8.09474 8.86398 10.1897 8.28002 GeneID:23649,Genbank:NM_002689.3,HGNC:HGNC:30073 DNA polymerase alpha 2, accessory subunit GO:0000060,GO:0000082,GO:0003677,GO:0003887,GO:0005654,GO:0005658,GO:0005829,GO:0006260,GO:0006270,GO:0032201,GO:0046982 protein import into nucleus, translocation|G1/S transition of mitotic cell cycle|DNA binding|DNA-directed DNA polymerase activity|nucleoplasm|alpha DNA polymerase:primase complex|cytosol|DNA replication|DNA replication initiation|telomere maintenance via semi-conservative replication|protein heterodimerization activity hsa00230,hsa00240,hsa03030 Purine metabolism|Pyrimidine metabolism|DNA replication POLB 532.130162685127 566.070325526891 498.189999843364 0.880084995410517 -0.184285234164876 0.279767365547845 1 10.5193 11.2412 9.52697 9.4929 GeneID:5423,Genbank:XM_005273540.4,HGNC:HGNC:9174,MIM:174760 DNA polymerase beta hsa03410,hsa05166,hsa05203 Base excision repair|Human T-cell leukemia virus 1 infection|Viral carcinogenesis POLD1 2063.58530677537 2113.15025620852 2014.02035734222 0.953089043916752 -0.0693170882904572 0.608923108935298 1 21.6443 22.1854 21.0656 22.1296 GeneID:5424,Genbank:XM_005259008.4,HGNC:HGNC:9175,MIM:174761 DNA polymerase delta 1, catalytic subunit hsa00230,hsa00240,hsa03030,hsa03410,hsa03420,hsa03430,hsa03440,hsa05166 Purine metabolism|Pyrimidine metabolism|DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination|Human T-cell leukemia virus 1 infection POLD2 4954.05812121757 4955.41951897082 4952.69672346432 0.999450541877216 -0.000792918366589768 0.972020119013191 1 72.4927 77.0766 74.5601 77.8813 GeneID:5425,Genbank:NM_006230.3,HGNC:HGNC:9176,MIM:600815 DNA polymerase delta 2, accessory subunit hsa00230,hsa00240,hsa03030,hsa03410,hsa03420,hsa03430,hsa03440,hsa05166 Purine metabolism|Pyrimidine metabolism|DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination|Human T-cell leukemia virus 1 infection POLD3 653.993309188163 699.270643307359 608.715975068967 0.870501258554065 -0.20008171118859 0.22743877098957 1 4.82154 4.95846 4.65873 4.17587 GeneID:10714,Genbank:NM_006591.2,HGNC:HGNC:20932,MIM:611415 DNA polymerase delta 3, accessory subunit GO:0000723,GO:0000731,GO:0003887,GO:0005634,GO:0005654,GO:0005737,GO:0006266,GO:0006283,GO:0006296,GO:0006297,GO:0006298,GO:0019985,GO:0032201,GO:0033683,GO:0042769,GO:0043625 telomere maintenance|DNA synthesis involved in DNA repair|DNA-directed DNA polymerase activity|nucleus|nucleoplasm|cytoplasm|DNA ligation|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|mismatch repair|translesion synthesis|telomere maintenance via semi-conservative replication|nucleotide-excision repair, DNA incision|DNA damage response, detection of DNA damage|delta DNA polymerase complex hsa00230,hsa00240,hsa03030,hsa03410,hsa03420,hsa03430,hsa03440,hsa05166 Purine metabolism|Pyrimidine metabolism|DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination|Human T-cell leukemia virus 1 infection POLD4 545.122394305007 470.488818836699 619.755969773316 1.31725972001989 0.397539825354016 0.137962483962259 1 8.89366 9.19336 10.8484 14.1752 GeneID:57804,Genbank:NM_001256870.1,HGNC:HGNC:14106,MIM:611525 DNA polymerase delta 4, accessory subunit hsa00230,hsa00240,hsa03030,hsa03410,hsa03420,hsa03430,hsa03440,hsa05166 Purine metabolism|Pyrimidine metabolism|DNA replication|Base excision repair|Nucleotide excision repair|Mismatch repair|Homologous recombination|Human T-cell leukemia virus 1 infection POLDIP2 5189.83409914113 4872.8463750677 5506.82182321455 1.13010372159291 0.176455190127683 0.189148972816659 1 69.6708 72.8902 84.7833 80.7496 GeneID:26073,Genbank:NM_001290145.1,HGNC:HGNC:23781,MIM:611519 DNA polymerase delta interacting protein 2 GO:0003677,GO:0005634,GO:0005739,GO:0016242,GO:0042645,GO:0045931,GO:0070584 DNA binding|nucleus|mitochondrion|negative regulation of macroautophagy|mitochondrial nucleoid|positive regulation of mitotic cell cycle|mitochondrion morphogenesis POLDIP3 2520.89182880603 2654.15929665068 2387.62436096138 0.899578395303684 -0.152679081795772 0.26460128774333 1 25.5365 25.5569 22.3666 24.4174 GeneID:84271,Genbank:NM_178136.2,HGNC:HGNC:23782,MIM:611520 DNA polymerase delta interacting protein 3 GO:0003723,GO:0005654,GO:0005737,GO:0005829,GO:0006369,GO:0006405,GO:0006406,GO:0016607,GO:0016973,GO:0031124,GO:0036464,GO:0045727 RNA binding|nucleoplasm|cytoplasm|cytosol|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|nuclear speck|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|cytoplasmic ribonucleoprotein granule|positive regulation of translation POLE 2054.84326286532 2065.99957441784 2043.68695131279 0.989200083397237 -0.0156657335291285 0.887103989835656 1 6.70831 7.45117 7.59148 7.07146 GeneID:5426,Genbank:NM_006231.3,HGNC:HGNC:9177,MIM:174762 DNA polymerase epsilon, catalytic subunit hsa00230,hsa00240,hsa03030,hsa03410,hsa03420,hsa05166 Purine metabolism|Pyrimidine metabolism|DNA replication|Base excision repair|Nucleotide excision repair|Human T-cell leukemia virus 1 infection POLE2 196.327333477213 208.026337799927 184.628329154498 0.887523816008662 -0.172142261268219 0.473639245672148 1 2.57463 2.52489 2.40512 2.7804 GeneID:5427,Genbank:NM_001197330.1,HGNC:HGNC:9178,MIM:602670 DNA polymerase epsilon 2, accessory subunit hsa00230,hsa00240,hsa03030,hsa03410,hsa03420,hsa05166 Purine metabolism|Pyrimidine metabolism|DNA replication|Base excision repair|Nucleotide excision repair|Human T-cell leukemia virus 1 infection POLE3 2697.01625496124 2829.8615562325 2564.17095368999 0.906111801845093 -0.142239024730414 0.293833719407595 1 50.7462 54.7024 49.9043 47.2914 GeneID:54107,Genbank:NM_001278255.1,HGNC:HGNC:13546,MIM:607267 DNA polymerase epsilon 3, accessory subunit GO:0003677,GO:0003887,GO:0005671,GO:0008622,GO:0043966,GO:0046982 DNA binding|DNA-directed DNA polymerase activity|Ada2/Gcn5/Ada3 transcription activator complex|epsilon DNA polymerase complex|histone H3 acetylation|protein heterodimerization activity hsa00230,hsa00240,hsa03030,hsa03410,hsa03420,hsa05166 Purine metabolism|Pyrimidine metabolism|DNA replication|Base excision repair|Nucleotide excision repair|Human T-cell leukemia virus 1 infection POLE4 464.955906707771 452.126871246814 477.784942168727 1.05674971463465 0.0796337227824889 0.81272289450369 1 31.5041 39.3849 34.2832 41.9817 GeneID:56655,Genbank:NM_019896.3,HGNC:HGNC:18755,MIM:607269 DNA polymerase epsilon 4, accessory subunit GO:0000082,GO:0003677,GO:0003887,GO:0005634,GO:0005654,GO:0005671,GO:0006270,GO:0008622,GO:0032201,GO:0043966,GO:0046982 G1/S transition of mitotic cell cycle|DNA binding|DNA-directed DNA polymerase activity|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|DNA replication initiation|epsilon DNA polymerase complex|telomere maintenance via semi-conservative replication|histone H3 acetylation|protein heterodimerization activity hsa00230,hsa00240,hsa03030,hsa03410,hsa03420,hsa05166 Purine metabolism|Pyrimidine metabolism|DNA replication|Base excision repair|Nucleotide excision repair|Human T-cell leukemia virus 1 infection POLG 1946.76413875097 1915.32815695458 1978.20012054736 1.03282568752748 0.0465967876396681 0.755268340989137 1 13.6491 14.3041 15.0825 14.9513 GeneID:5428,Genbank:NM_001126131.1,HGNC:HGNC:9179,MIM:174763 DNA polymerase gamma, catalytic subunit POLG2 145.900699825406 143.511434531789 148.289965119024 1.03329721149276 0.0472552821546894 0.870529340704471 1 2.99457 3.15189 3.1978 3.15306 GeneID:11232,Genbank:NM_007215.3,HGNC:HGNC:9180,MIM:604983 DNA polymerase gamma 2, accessory subunit GO:0000262,GO:0001701,GO:0003677,GO:0003887,GO:0004820,GO:0005759,GO:0006260,GO:0006261,GO:0006281,GO:0007005,GO:0022904,GO:0032042,GO:0042645,GO:0042802,GO:0070062,GO:0070150,GO:0070584 mitochondrial chromosome|in utero embryonic development|DNA binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|mitochondrial matrix|DNA replication|DNA-dependent DNA replication|DNA repair|mitochondrion organization|respiratory electron transport chain|mitochondrial DNA metabolic process|mitochondrial nucleoid|identical protein binding|extracellular exosome|mitochondrial glycyl-tRNA aminoacylation|mitochondrion morphogenesis POLH 1213.55885903037 1154.02035935248 1273.09735870825 1.10318448750989 0.141674075570496 0.345937097880079 1 3.3012 3.57526 3.91819 3.86438 GeneID:5429,Genbank:NM_006502.2,HGNC:HGNC:9181,MIM:603968 DNA polymerase eta hsa01524,hsa03460 Platinum drug resistance|Fanconi anemia pathway POLI 60.2557849808582 60.902107010805 59.6094629509113 0.978775051909708 -0.0309507659923808 0.978057435602626 1 0.305322 0.243828 0.260861 0.242934 GeneID:11201,Genbank:NM_001351621.1,HGNC:HGNC:9182,MIM:605252 DNA polymerase iota hsa03460 Fanconi anemia pathway POLK 105.223938827711 106.227790363452 104.22008729197 0.981100020393785 -0.0275278722344728 0.990064424083507 1 0.362742 0.23472 0.391833 0.217718 GeneID:51426,Genbank:XM_005248534.5,HGNC:HGNC:9183,MIM:605650 DNA polymerase kappa hsa03460,hsa05169,hsa05200,hsa05202,hsa05210,hsa05212,hsa05213,hsa05214,hsa05216,hsa05217,hsa05218,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 Fanconi anemia pathway|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Thyroid cancer|Basal cell carcinoma|Melanoma|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer POLL 454.463226605703 438.394046336045 470.532406875361 1.07330929972229 0.102065883060038 0.559968660806668 1 4.15288 3.84651 4.03028 4.40912 GeneID:27343,Genbank:XM_024447945.1,HGNC:HGNC:9184,MIM:606343 DNA polymerase lambda hsa03410,hsa03450 Base excision repair|Non-homologous end-joining POLM 418.548215510679 453.259884529037 383.836546492321 0.846835468113726 -0.239846399703179 0.18430776651426 1 3.195 3.54362 2.82039 2.89715 GeneID:27434,Genbank:NM_001284330.1,HGNC:HGNC:9185,MIM:606344 DNA polymerase mu hsa03450 Non-homologous end-joining POLN 47.9131518920669 54.1469685878798 41.6793351962539 0.769744572655235 -0.377548304791329 0.378770740484693 1 0.52816 0.375464 0.399478 0.389055 GeneID:353497,Genbank:NM_181808.3,HGNC:HGNC:18870,MIM:610887 DNA polymerase nu hsa03460 Fanconi anemia pathway POLQ 206.10906068847 190.691542287788 221.526579089152 1.16170112439926 0.21623894842505 0.592742100835971 1 0.743623 0.677792 1.02936 0.58973 GeneID:10721,Genbank:XM_011512348.2,HGNC:HGNC:9186,MIM:604419 DNA polymerase theta GO:0000724,GO:0003682,GO:0003684,GO:0003887,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0006261,GO:0006281,GO:0006284,GO:0006302,GO:0006974,GO:0016446,GO:0042802,GO:0043142,GO:0051260,GO:0051575,GO:0097681,GO:2000042 double-strand break repair via homologous recombination|chromatin binding|damaged DNA binding|DNA-directed DNA polymerase activity|ATP binding|nucleus|nucleoplasm|chromosome|cytoplasm|DNA-dependent DNA replication|DNA repair|base-excision repair|double-strand break repair|cellular response to DNA damage stimulus|somatic hypermutation of immunoglobulin genes|identical protein binding|single-stranded DNA-dependent ATPase activity|protein homooligomerization|5'-deoxyribose-5-phosphate lyase activity|double-strand break repair via alternative nonhomologous end joining|negative regulation of double-strand break repair via homologous recombination POLR1A 1882.98163559259 1872.9124590475 1893.05081213769 1.01075242625084 0.0154296667170569 0.915019576570783 1 5.01826 4.91524 5.47537 4.73459 GeneID:25885,Genbank:NM_015425.5,HGNC:HGNC:17264,MIM:616404 RNA polymerase I subunit A GO:0001054,GO:0003677,GO:0003682,GO:0005654,GO:0005736,GO:0006361,GO:0006362,GO:0006363,GO:0008270,GO:0045815,GO:1904750 RNA polymerase I activity|DNA binding|chromatin binding|nucleoplasm|DNA-directed RNA polymerase I complex|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|zinc ion binding|positive regulation of gene expression, epigenetic|negative regulation of protein localization to nucleolus hsa00230,hsa00240,hsa03020 Purine metabolism|Pyrimidine metabolism|RNA polymerase POLR1B 844.974738880938 848.566882113266 841.382595648609 0.991533623788422 -0.0122663985297465 0.942347292238634 1 6.00905 6.05357 6.6511 5.44276 GeneID:84172,Genbank:NM_001282777.1,HGNC:HGNC:20454,MIM:602000 RNA polymerase I subunit B GO:0003677,GO:0003899,GO:0005654,GO:0005730,GO:0005736,GO:0005829,GO:0006361,GO:0006362,GO:0006363,GO:0007566,GO:0009303,GO:0017126,GO:0032549,GO:0045815,GO:0046872 DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|nucleolus|DNA-directed RNA polymerase I complex|cytosol|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|embryo implantation|rRNA transcription|nucleologenesis|ribonucleoside binding|positive regulation of gene expression, epigenetic|metal ion binding hsa00230,hsa00240,hsa03020 Purine metabolism|Pyrimidine metabolism|RNA polymerase POLR1C 823.99407967319 929.274775957068 718.713383389313 0.773413205635657 -0.370688696975016 0.0170149456181732 0.540331203073832 12.3836 14.4785 10.9165 9.97238 GeneID:9533,Genbank:NM_001318876.1,HGNC:HGNC:20194,MIM:610060 RNA polymerase I and III subunit C GO:0003677,GO:0003899,GO:0005634,GO:0005654,GO:0005666,GO:0005736,GO:0005829,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006383,GO:0032481,GO:0045815,GO:0046983 DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|cytosol|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase III promoter|positive regulation of type I interferon production|positive regulation of gene expression, epigenetic|protein dimerization activity hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLR1D 1190.98132037639 1231.96910422732 1149.99353652546 0.933459721172739 -0.0993403234461153 0.500033323344527 1 11.9596 12.3496 11.497 11.6604 GeneID:51082,Genbank:NM_001206559.1,HGNC:HGNC:20422,MIM:613715 RNA polymerase I and III subunit D GO:0003677,GO:0003899,GO:0005634,GO:0006351,GO:0046983 DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|transcription, DNA-templated|protein dimerization activity hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLR1E 1550.45539849139 1674.60232239331 1426.30847458947 0.851729664718854 -0.231532496897391 0.102584640635392 1 19.8999 20.9327 18.6265 16.4548 GeneID:64425,Genbank:NM_001282766.1,HGNC:HGNC:17631 RNA polymerase I subunit E GO:0001179,GO:0001189,GO:0001650,GO:0003677,GO:0003899,GO:0005634,GO:0005654,GO:0005730,GO:0005736,GO:0006361,GO:0006362,GO:0006363,GO:0009303,GO:0045815 RNA polymerase I transcription factor binding|RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript|fibrillar center|DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|nucleolus|DNA-directed RNA polymerase I complex|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|rRNA transcription|positive regulation of gene expression, epigenetic hsa00230,hsa00240,hsa03020 Purine metabolism|Pyrimidine metabolism|RNA polymerase POLR2A 5226.55154997468 5320.65967324713 5132.44342670223 0.964625392694957 -0.0519593069387964 0.675884371288617 1 24.6576 25.851 26.7033 23.1434 GeneID:5430,Genbank:NM_000937.4,HGNC:HGNC:9187,MIM:180660 RNA polymerase II subunit A GO:0003677,GO:0003899,GO:0005634,GO:0005665,GO:0005737,GO:0006366,GO:0033120,GO:0046872 DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|DNA-directed RNA polymerase II, core complex|cytoplasm|transcription from RNA polymerase II promoter|positive regulation of RNA splicing|metal ion binding hsa00230,hsa00240,hsa03020,hsa05016,hsa05168 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Huntington disease|Herpes simplex infection POLR2B 5758.06560019268 6168.08032106706 5348.05087931831 0.867052729688369 -0.205808361478671 0.127594585229374 1 53.8854 49.0745 48.4522 42.3359 GeneID:5431,Genbank:NM_001303269.1,HGNC:HGNC:9188,MIM:180661 RNA polymerase II subunit B GO:0000398,GO:0003677,GO:0003682,GO:0003723,GO:0003899,GO:0005634,GO:0005654,GO:0005665,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016020,GO:0016070,GO:0032549,GO:0035019,GO:0042795,GO:0046872,GO:0050434,GO:0060964 mRNA splicing, via spliceosome|DNA binding|chromatin binding|RNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|membrane|RNA metabolic process|ribonucleoside binding|somatic stem cell population maintenance|snRNA transcription from RNA polymerase II promoter|metal ion binding|positive regulation of viral transcription|regulation of gene silencing by miRNA hsa00230,hsa00240,hsa03020,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Huntington disease POLR2C 2503.20531090972 2305.70704855562 2700.70357326382 1.17131253727816 0.228126076539752 0.103864360723459 1 47.1451 53.2797 57.8709 61.605 GeneID:5432,Genbank:NM_032940.2,HGNC:HGNC:9189,MIM:180663 RNA polymerase II subunit C GO:0000398,GO:0003677,GO:0003899,GO:0005634,GO:0005654,GO:0005665,GO:0005829,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0015630,GO:0016070,GO:0035019,GO:0042795,GO:0046983,GO:0050434,GO:0060964 mRNA splicing, via spliceosome|DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|microtubule cytoskeleton|RNA metabolic process|somatic stem cell population maintenance|snRNA transcription from RNA polymerase II promoter|protein dimerization activity|positive regulation of viral transcription|regulation of gene silencing by miRNA hsa00230,hsa00240,hsa03020,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Huntington disease POLR2D 1494.7645119298 1370.36606832887 1619.16295553072 1.1815550552162 0.240686854057306 0.089505579287729 0.979181255377232 25.3467 22.4227 30.1593 27.7747 GeneID:5433,Genbank:NM_004805.3,HGNC:HGNC:9191,MIM:606017 RNA polymerase II subunit D GO:0000166,GO:0000288,GO:0000398,GO:0000932,GO:0003899,GO:0005634,GO:0005654,GO:0005665,GO:0005829,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0016607,GO:0031369,GO:0031990,GO:0034402,GO:0035019,GO:0042795,GO:0045948,GO:0050434,GO:0060964 nucleotide binding|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|mRNA splicing, via spliceosome|P-body|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|nuclear speck|translation initiation factor binding|mRNA export from nucleus in response to heat stress|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|somatic stem cell population maintenance|snRNA transcription from RNA polymerase II promoter|positive regulation of translational initiation|positive regulation of viral transcription|regulation of gene silencing by miRNA hsa00230,hsa00240,hsa03020,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Huntington disease POLR2E 5578.14322122231 5540.87320351365 5615.41323893097 1.01345275964266 0.0192788416240833 0.938050369290441 1 47.976 52.0868 48.3835 55.6946 GeneID:5434,Genbank:NM_001316323.1,HGNC:HGNC:9192,MIM:180664 RNA polymerase II subunit E GO:0003677,GO:0003899,GO:0005634,GO:0005665,GO:0005666,GO:0005736,GO:0006360,GO:0006366,GO:0006383 DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|DNA-directed RNA polymerase II, core complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|transcription from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter hsa00230,hsa00240,hsa03020,hsa04623,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2F 1393.533277054 1403.56849614984 1383.49805795816 0.98570042128565 -0.0207788523380663 0.886434082883943 1 7.74557 7.9086 7.76833 9.85501 GeneID:5435,Genbank:NM_001301130.1,HGNC:HGNC:9193,MIM:604414 RNA polymerase II subunit F GO:0003677,GO:0003899,GO:0005634,GO:0005665,GO:0005666,GO:0005736,GO:0006360,GO:0006366,GO:0006383 DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|DNA-directed RNA polymerase II, core complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|transcription from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter hsa00230,hsa00240,hsa03020,hsa04623,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2G 1542.44684641195 1623.42317418079 1461.47051864312 0.900240024835546 -0.151618386253557 0.428072381128461 1 77.6565 79.0325 64.026 80.0214 GeneID:5436,Genbank:NM_002696.2,HGNC:HGNC:9194,MIM:602013 RNA polymerase II subunit G GO:0000291,GO:0000932,GO:0003697,GO:0003727,GO:0003899,GO:0005634,GO:0005665,GO:0006366,GO:0006367,GO:0006915,GO:0031369,GO:0045948,GO:0060213 nuclear-transcribed mRNA catabolic process, exonucleolytic|P-body|single-stranded DNA binding|single-stranded RNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|DNA-directed RNA polymerase II, core complex|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|apoptotic process|translation initiation factor binding|positive regulation of translational initiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening hsa00230,hsa00240,hsa03020,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Huntington disease POLR2H 1858.77659262473 2000.17713607725 1717.37604917222 0.858611979007189 -0.219921794063296 0.184608002495477 1 28.4054 29.0677 22.2493 27.3044 GeneID:5437,Genbank:XM_006713666.3,HGNC:HGNC:9195,MIM:606023 RNA polymerase II subunit H GO:0000398,GO:0003697,GO:0003899,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006383,GO:0008543,GO:0016070,GO:0032481,GO:0032993,GO:0035019,GO:0042795,GO:0045815,GO:0050434,GO:0060964 mRNA splicing, via spliceosome|single-stranded DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription from RNA polymerase III promoter|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of type I interferon production|protein-DNA complex|somatic stem cell population maintenance|snRNA transcription from RNA polymerase II promoter|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA hsa00230,hsa00240,hsa03020,hsa04623,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2I 882.222816630794 954.729062893527 809.71657036806 0.848111366709658 -0.237674375322359 0.269373398550754 1 39.5083 45.6223 33.2307 39.0719 GeneID:5438,Genbank:NM_006233.4,HGNC:HGNC:9196,MIM:180662 RNA polymerase II subunit I GO:0000398,GO:0001193,GO:0003676,GO:0003899,GO:0005634,GO:0005654,GO:0005665,GO:0005730,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006379,GO:0008270,GO:0008543,GO:0016070,GO:0035019,GO:0042795,GO:0050434,GO:0060964 mRNA splicing, via spliceosome|maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter|nucleic acid binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|nucleolus|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|mRNA cleavage|zinc ion binding|fibroblast growth factor receptor signaling pathway|RNA metabolic process|somatic stem cell population maintenance|snRNA transcription from RNA polymerase II promoter|positive regulation of viral transcription|regulation of gene silencing by miRNA hsa00230,hsa00240,hsa03020,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Huntington disease POLR2J 2030.87308858531 2054.15263387746 2007.59354329316 0.977334162118025 -0.0330761738356612 0.868078132744271 1 33.3784 38.8399 32.0914 38.9568 GeneID:5439,Genbank:NM_006234.4,HGNC:HGNC:9197,MIM:604150 RNA polymerase II subunit J GO:0000398,GO:0003677,GO:0003899,GO:0005634,GO:0005654,GO:0005665,GO:0006283,GO:0006351,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0008543,GO:0016070,GO:0030275,GO:0035019,GO:0042795,GO:0046983,GO:0050434,GO:0060964 mRNA splicing, via spliceosome|DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|fibroblast growth factor receptor signaling pathway|RNA metabolic process|LRR domain binding|somatic stem cell population maintenance|snRNA transcription from RNA polymerase II promoter|protein dimerization activity|positive regulation of viral transcription|regulation of gene silencing by miRNA hsa00230,hsa00240,hsa03020,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Huntington disease POLR2J2 10.0794246002077 9.98372448277907 10.1751247176364 1.01917122564705 0.0273964515428845 1 1 1.11027 0.538535 0.837533 1.14823 GeneID:246721,Genbank:NM_032959.5,HGNC:HGNC:23208,MIM:609881 RNA polymerase II subunit J2 GO:0016021 integral component of membrane hsa00230,hsa00240,hsa03020,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Huntington disease POLR2J3 20.1124640980211 18.9010622673815 21.3238659286607 1.12818346540556 0.174001698151672 0.827390961992354 1 0.276371 0.443898 0.659087 0.145251 GeneID:548644,Genbank:NM_001097615.2,HGNC:HGNC:33853 RNA polymerase II subunit J3 GO:0016021 integral component of membrane hsa00230,hsa00240,hsa03020,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Huntington disease POLR2K 1556.2871914812 1673.32217928447 1439.25220367793 0.860116612028274 -0.217395825549435 0.133404343156418 1 71.6249 74.1246 59.5315 65.6659 GeneID:5440,Genbank:NM_005034.3,HGNC:HGNC:9198,MIM:606033 RNA polymerase II subunit K GO:0000398,GO:0003677,GO:0003899,GO:0005634,GO:0005654,GO:0005665,GO:0005666,GO:0005736,GO:0005829,GO:0006283,GO:0006351,GO:0006356,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006370,GO:0006383,GO:0008270,GO:0008543,GO:0016070,GO:0032481,GO:0035019,GO:0042795,GO:0045815,GO:0050434,GO:0060964 mRNA splicing, via spliceosome|DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase I complex|cytosol|transcription-coupled nucleotide-excision repair|transcription, DNA-templated|regulation of transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|transcription from RNA polymerase III promoter|zinc ion binding|fibroblast growth factor receptor signaling pathway|RNA metabolic process|positive regulation of type I interferon production|somatic stem cell population maintenance|snRNA transcription from RNA polymerase II promoter|positive regulation of gene expression, epigenetic|positive regulation of viral transcription|regulation of gene silencing by miRNA hsa00230,hsa00240,hsa03020,hsa04623,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2L 2445.98214039139 2497.25528913434 2394.70899164844 0.958936397919714 -0.0604929641577408 0.797024009852465 1 120.861 133.269 106.967 135.958 GeneID:5441,Genbank:NM_021128.4,HGNC:HGNC:9199,MIM:601189 RNA polymerase II subunit L GO:0003677,GO:0003899,GO:0005634,GO:0005665,GO:0006366,GO:0008270 DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|DNA-directed RNA polymerase II, core complex|transcription from RNA polymerase II promoter|zinc ion binding hsa00230,hsa00240,hsa03020,hsa04623,hsa05016 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway|Huntington disease POLR2M 45.0844577562241 49.4579769772618 40.7109385351864 0.823142009102054 -0.280786747893428 0.5078483903621 1 13.1766 12.8181 13.1113 10.7305 GeneID:81488,Genbank:NM_015532.4,HGNC:HGNC:14862,MIM:606485 RNA polymerase II subunit M GO:0003899,GO:0005635,GO:0016591,GO:0043025,GO:0051685 DNA-directed 5'-3' RNA polymerase activity|nuclear envelope|DNA-directed RNA polymerase II, holoenzyme|neuronal cell body|maintenance of ER location POLR3A 2038.04899663082 2199.12142295745 1876.9765703042 0.853512021077936 -0.228516622211509 0.10253011144674 1 10.2551 10.4879 9.29104 8.58822 GeneID:11128,Genbank:NM_007055.3,HGNC:HGNC:30074,MIM:614258 RNA polymerase III subunit A GO:0003677,GO:0003682,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006351,GO:0006383,GO:0016020,GO:0032481,GO:0032728,GO:0045087,GO:0046872,GO:0051607,GO:1903146,GO:1903955 DNA binding|chromatin binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|transcription, DNA-templated|transcription from RNA polymerase III promoter|membrane|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|metal ion binding|defense response to virus|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLR3B 240.590309640193 255.33192407062 225.848695209767 0.884529797955471 -0.177017349780031 0.418225096036279 1 1.23591 1.22611 1.17655 0.934496 GeneID:55703,Genbank:NM_018082.5,HGNC:HGNC:30348,MIM:614366 RNA polymerase III subunit B GO:0003677,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006383,GO:0032481,GO:0032549,GO:0032728,GO:0045087,GO:0045089,GO:0046872,GO:0051607 DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|transcription from RNA polymerase III promoter|positive regulation of type I interferon production|ribonucleoside binding|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|metal ion binding|defense response to virus hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLR3C 858.02107841958 896.054764827591 819.98739201157 0.915108567241806 -0.127985181949875 0.417326449770813 1 4.12551 4.02838 3.68213 3.69472 GeneID:10623,Genbank:XM_005272927.3,HGNC:HGNC:30076,MIM:617454 RNA polymerase III subunit C GO:0003697,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006359,GO:0006383,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607 single-stranded DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase III promoter|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLR3D 1032.40364970465 1105.70622131341 959.101078095894 0.867410402156036 -0.205213350500108 0.171960049833279 1 15.6715 16.7934 14.8955 13.6359 GeneID:661,Genbank:NM_001722.2,HGNC:HGNC:1080,MIM:187280 RNA polymerase III subunit D GO:0000790,GO:0003677,GO:0003682,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006383,GO:0016607,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607 nuclear chromatin|DNA binding|chromatin binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|transcription from RNA polymerase III promoter|nuclear speck|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLR3E 708.214718459784 755.388723159031 661.040713760536 0.875100055764757 -0.19248011599601 0.224573720779126 1 4.26383 4.75289 4.21537 4.04299 GeneID:55718,Genbank:NM_018119.3,HGNC:HGNC:30347,MIM:617815 RNA polymerase III subunit E GO:0003899,GO:0005634,GO:0005654,GO:0005666,GO:0005829,GO:0006383,GO:0032481,GO:0045087,GO:0051607 DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|transcription from RNA polymerase III promoter|positive regulation of type I interferon production|innate immune response|defense response to virus hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLR3F 207.803048799715 242.58025896462 173.025838634809 0.713272544820081 -0.487474652258635 0.0485536317097048 0.806708656465773 3.72654 3.04551 2.78481 2.12292 GeneID:10621,Genbank:NM_001282526.1,HGNC:HGNC:15763,MIM:617455 RNA polymerase III subunit F GO:0003690,GO:0003899,GO:0005654,GO:0005666,GO:0005829,GO:0006359,GO:0006383,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607 double-stranded DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase III promoter|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLR3G 154.015431590618 196.562590456168 111.468272725069 0.567087930955637 -0.818355642404067 0.00128220025494608 0.119136883419797 1.47501 1.30417 0.834368 0.685899 GeneID:10622,Genbank:XM_011543100.3,HGNC:HGNC:30075,MIM:617456 RNA polymerase III subunit G GO:0000790,GO:0003899,GO:0005634,GO:0005654,GO:0005666,GO:0005829,GO:0006359,GO:0006383,GO:0008283,GO:0032481,GO:0032728,GO:0045087,GO:0045089,GO:0051607 nuclear chromatin|DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase III promoter|cell proliferation|positive regulation of type I interferon production|positive regulation of interferon-beta production|innate immune response|positive regulation of innate immune response|defense response to virus hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLR3GL 320.879816787533 303.003120229431 338.756513345636 1.11799678197747 0.160916035558717 0.431796219775442 1 5.62356 6.63419 7.3285 6.91737 GeneID:84265,Genbank:XM_005277431.4,HGNC:HGNC:28466,MIM:617457 RNA polymerase III subunit G like GO:0003899,GO:0005634,GO:0005654,GO:0005666,GO:0005829,GO:0006383,GO:0032481 DNA-directed 5'-3' RNA polymerase activity|nucleus|nucleoplasm|DNA-directed RNA polymerase III complex|cytosol|transcription from RNA polymerase III promoter|positive regulation of type I interferon production hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLR3H 1907.60616346038 1853.04207963217 1962.17024728859 1.05889135970301 0.0825545790773822 0.57036623927931 1 11.9875 12.3447 12.6938 13.4048 GeneID:171568,Genbank:NM_001282884.1,HGNC:HGNC:30349 RNA polymerase III subunit H GO:0003677,GO:0003899,GO:0005654,GO:0005666,GO:0005813,GO:0005829,GO:0006139,GO:0006383,GO:0006384,GO:0032481,GO:0043231,GO:0045087,GO:0051607 DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|DNA-directed RNA polymerase III complex|centrosome|cytosol|nucleobase-containing compound metabolic process|transcription from RNA polymerase III promoter|transcription initiation from RNA polymerase III promoter|positive regulation of type I interferon production|intracellular membrane-bounded organelle|innate immune response|defense response to virus hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLR3K 532.560350261261 615.394032335206 449.726668187317 0.730794652786542 -0.452462017061207 0.00791240985214856 0.350069492243125 34.4406 39.4774 26.8423 26.556 GeneID:51728,Genbank:NM_016310.4,HGNC:HGNC:14121,MIM:606007 RNA polymerase III subunit K GO:0003676,GO:0003899,GO:0005654,GO:0005666,GO:0005730,GO:0005829,GO:0006379,GO:0006383,GO:0006386,GO:0008270,GO:0032481,GO:0045087,GO:0051607 nucleic acid binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|DNA-directed RNA polymerase III complex|nucleolus|cytosol|mRNA cleavage|transcription from RNA polymerase III promoter|termination of RNA polymerase III transcription|zinc ion binding|positive regulation of type I interferon production|innate immune response|defense response to virus hsa00230,hsa00240,hsa03020,hsa04623 Purine metabolism|Pyrimidine metabolism|RNA polymerase|Cytosolic DNA-sensing pathway POLRMT 1748.70337588541 1807.07447140011 1690.33228037071 0.935397133390441 -0.0963490873938531 0.519519962368955 1 20.8883 23.2045 20.7555 21.074 GeneID:5442,Genbank:XM_005259580.4,HGNC:HGNC:9200,MIM:601778 RNA polymerase mitochondrial GO:0003677,GO:0003723,GO:0003899,GO:0005739,GO:0005759,GO:0006390,GO:0006391,GO:0007005,GO:0034245,GO:0042645 DNA binding|RNA binding|DNA-directed 5'-3' RNA polymerase activity|mitochondrion|mitochondrial matrix|transcription from mitochondrial promoter|transcription initiation from mitochondrial promoter|mitochondrion organization|mitochondrial DNA-directed RNA polymerase complex|mitochondrial nucleoid POM121 2465.78647583608 2378.4385127983 2553.13443887385 1.07344983910053 0.102254777529535 0.479041098373563 1 7.86394 8.2917 9.55436 8.18745 GeneID:9883,Genbank:NM_001257190.2,HGNC:HGNC:19702,MIM:615753 POM121 transmembrane nucleoporin GO:0005487,GO:0005635,GO:0005643,GO:0005654,GO:0005789,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0007077,GO:0008139,GO:0016021,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0043657,GO:0060964,GO:0075733,GO:1900034 nucleocytoplasmic transporter activity|nuclear envelope|nuclear pore|nucleoplasm|endoplasmic reticulum membrane|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|mitotic nuclear envelope disassembly|nuclear localization sequence binding|integral component of membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport POM121C 2751.28640183077 2458.06716028626 3044.50564337528 1.23857707900086 0.308683653026813 0.0251724242039729 0.631315976879816 16.2105 16.2039 21.6163 19.5399 GeneID:100101267,Genbank:NM_001099415.2,HGNC:HGNC:34005,MIM:615754 POM121 transmembrane nucleoporin C GO:0005487,GO:0005635,GO:0005643,GO:0005789,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0007077,GO:0008139,GO:0016021,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031965,GO:0043657,GO:0060964,GO:0075733,GO:1900034 nucleocytoplasmic transporter activity|nuclear envelope|nuclear pore|endoplasmic reticulum membrane|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|mitotic nuclear envelope disassembly|nuclear localization sequence binding|integral component of membrane|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear membrane|host cell|regulation of gene silencing by miRNA|intracellular transport of virus|regulation of cellular response to heat hsa03013 RNA transport POMGNT1 3952.36410327979 3783.16065654144 4121.56755001815 1.08945083865037 0.123601096467102 0.374406928639474 1 29.0412 31.9273 33.097 35.0787 GeneID:55624,Genbank:NM_001243766.1,HGNC:HGNC:19139,MIM:606822 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) hsa00515 Mannose type O-glycan biosynthesis POMGNT2 1143.54657209106 1131.27617810945 1155.81696607267 1.02169301222645 0.030961775268367 0.85503219211105 1 16.3908 16.8617 17.3732 17.3895 GeneID:84892,Genbank:XM_011534163.2,HGNC:HGNC:25902,MIM:614828 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) GO:0001764,GO:0005783,GO:0005789,GO:0006493,GO:0008375,GO:0016021,GO:0035269,GO:0097363 neuron migration|endoplasmic reticulum|endoplasmic reticulum membrane|protein O-linked glycosylation|acetylglucosaminyltransferase activity|integral component of membrane|protein O-linked mannosylation|protein O-GlcNAc transferase activity hsa00515 Mannose type O-glycan biosynthesis POMK 93.3315198691358 103.306979261924 83.3560604763477 0.806877338509794 -0.309578723210718 0.321324162066836 1 1.92603 1.83333 1.65089 1.66737 GeneID:84197,Genbank:NM_032237.4,HGNC:HGNC:26267,MIM:615247 protein-O-mannose kinase GO:0001764,GO:0004672,GO:0005524,GO:0005789,GO:0006493,GO:0007420,GO:0007611,GO:0016021,GO:0016773,GO:0019200,GO:0019233,GO:0046835,GO:0050905 neuron migration|protein kinase activity|ATP binding|endoplasmic reticulum membrane|protein O-linked glycosylation|brain development|learning or memory|integral component of membrane|phosphotransferase activity, alcohol group as acceptor|carbohydrate kinase activity|sensory perception of pain|carbohydrate phosphorylation|neuromuscular process hsa00515 Mannose type O-glycan biosynthesis POMP 1380.06407682966 1429.82840409998 1330.29974955935 0.930391189421584 -0.104090659982908 0.482835413862295 1 50.0058 51.3784 47.0372 46.4264 GeneID:51371,Genbank:NM_015932.5,HGNC:HGNC:20330,MIM:613386 proteasome maturation protein GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0016607,GO:0031090,GO:0043248 nucleus|cytoplasm|endoplasmic reticulum|cytosol|nuclear speck|organelle membrane|proteasome assembly hsa03050 Proteasome POMT1 908.702400034573 847.174120147403 970.230679921743 1.14525533399548 0.195669282184374 0.212377996597842 1 4.5722 4.52674 5.4622 5.38689 GeneID:10585,Genbank:NM_001353198.1,HGNC:HGNC:9202,MIM:607423 protein O-mannosyltransferase 1 GO:0000030,GO:0001669,GO:0004169,GO:0005783,GO:0005789,GO:0005975,GO:0006493,GO:0007275,GO:0016021,GO:0016529,GO:0030198,GO:0046872,GO:0071712,GO:1904100 mannosyltransferase activity|acrosomal vesicle|dolichyl-phosphate-mannose-protein mannosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|carbohydrate metabolic process|protein O-linked glycosylation|multicellular organism development|integral component of membrane|sarcoplasmic reticulum|extracellular matrix organization|metal ion binding|ER-associated misfolded protein catabolic process|positive regulation of protein O-linked glycosylation hsa00514,hsa00515 Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis POMT2 710.903786426158 600.384115318159 821.423457534157 1.36816320848006 0.452240339887714 0.00530858070839359 0.285941071095182 4.50022 4.51745 6.03185 6.22077 GeneID:29954,Genbank:XM_011536677.3,HGNC:HGNC:19743,MIM:607439 protein O-mannosyltransferase 2 GO:0004169,GO:0005789,GO:0006493,GO:0016021,GO:0046872,GO:0071712,GO:1904100 dolichyl-phosphate-mannose-protein mannosyltransferase activity|endoplasmic reticulum membrane|protein O-linked glycosylation|integral component of membrane|metal ion binding|ER-associated misfolded protein catabolic process|positive regulation of protein O-linked glycosylation hsa00514,hsa00515 Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis POMZP3 500.587167840218 480.184385671368 520.989950009068 1.08497894882743 0.117667051225612 0.508077629201294 1 8.91642 9.32931 11.5155 9.54699 GeneID:22932,Genbank:NM_152992.2,HGNC:HGNC:9203,MIM:600587 POM121 and ZP3 fusion GO:0005654,GO:0007339,GO:0031012,GO:0031965,GO:0032190,GO:0035803,GO:2000344 nucleoplasm|binding of sperm to zona pellucida|extracellular matrix|nuclear membrane|acrosin binding|egg coat formation|positive regulation of acrosome reaction PON2 1666.26000986917 1807.86621575526 1524.65380398308 0.843344375095885 -0.245806226720395 0.092708907599031 0.987898138646211 34.6932 30.2713 28.6141 26.7286 GeneID:5445,Genbank:NM_001018161.1,HGNC:HGNC:9205,MIM:602447 paraoxonase 2 POP1 821.957346886728 859.77189777424 784.142795999217 0.912035852799085 -0.132837555981159 0.388393137892933 1 5.72317 6.65979 5.89622 5.56108 GeneID:10940,Genbank:NM_001145860.1,HGNC:HGNC:30129,MIM:602486 POP1 homolog, ribonuclease P/MRP subunit GO:0000171,GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005615,GO:0005654,GO:0005655,GO:0005730,GO:0008033,GO:0016078,GO:0030681 ribonuclease MRP activity|ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|extracellular space|nucleoplasm|nucleolar ribonuclease P complex|nucleolus|tRNA processing|tRNA catabolic process|multimeric ribonuclease P complex hsa03008,hsa03013 Ribosome biogenesis in eukaryotes|RNA transport POP4 1446.54671129455 1471.29236816762 1421.80105442148 0.966362012869154 -0.0493643506159571 0.731803735801431 1 20.5057 20.8944 18.8362 21.324 GeneID:10775,Genbank:NM_006627.2,HGNC:HGNC:30081,MIM:606114 POP4 homolog, ribonuclease P/MRP subunit GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005654,GO:0005655,GO:0006364,GO:0006379,GO:0008033,GO:0030677,GO:0030681,GO:0033204 ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|nucleoplasm|nucleolar ribonuclease P complex|rRNA processing|mRNA cleavage|tRNA processing|ribonuclease P complex|multimeric ribonuclease P complex|ribonuclease P RNA binding hsa03008,hsa03013 Ribosome biogenesis in eukaryotes|RNA transport POP5 453.704371140335 446.581181345266 460.827560935404 1.03190098505097 0.0453045451515195 0.829292424107238 1 15.622 14.5664 13.9612 16.9481 GeneID:51367,Genbank:XM_011538441.1,HGNC:HGNC:17689,MIM:609992 POP5 homolog, ribonuclease P/MRP subunit GO:0000172,GO:0001682,GO:0004526,GO:0005654,GO:0005655,GO:0009249,GO:0030681 ribonuclease MRP complex|tRNA 5'-leader removal|ribonuclease P activity|nucleoplasm|nucleolar ribonuclease P complex|protein lipoylation|multimeric ribonuclease P complex hsa03008,hsa03013 Ribosome biogenesis in eukaryotes|RNA transport POP7 1699.65760198657 1807.39002101183 1591.9251829613 0.880786750205744 -0.183135328478545 0.1912821897989 1 97.8902 102.932 86.0977 91.6079 GeneID:10248,Genbank:NM_005837.2,HGNC:HGNC:19949,MIM:606113 POP7 homolog, ribonuclease P/MRP subunit GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005634,GO:0005654,GO:0005655,GO:0005737,GO:0008033,GO:0030681,GO:0090502 ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|nucleus|nucleoplasm|nucleolar ribonuclease P complex|cytoplasm|tRNA processing|multimeric ribonuclease P complex|RNA phosphodiester bond hydrolysis, endonucleolytic hsa03008,hsa03013 Ribosome biogenesis in eukaryotes|RNA transport POPDC2 11.9344130655052 12.2419763938261 11.6268497371843 0.949752667636902 -0.0743762357926699 0.977252933055996 1 0.160791 0.192347 0.100668 0.25884 GeneID:64091,Genbank:NM_022135.3,HGNC:HGNC:17648,MIM:605823 popeye domain containing 2 GO:0002027,GO:0016021,GO:0042383 regulation of heart rate|integral component of membrane|sarcolemma POPDC3 1907.34061573278 2009.89806087382 1804.78317059173 0.897947615217401 -0.155296811914814 0.278983066635929 1 14.6287 13.9153 12.9314 12.236 GeneID:64208,Genbank:NM_022361.4,HGNC:HGNC:17649,MIM:605824 popeye domain containing 3 GO:0016021,GO:0030552,GO:0042391 integral component of membrane|cAMP binding|regulation of membrane potential POR 2108.02881840402 2037.70091161901 2178.35672518902 1.06902672161944 0.0962979154213912 0.513282899922658 1 27.751 30.3889 31.9291 31.6595 GeneID:5447,Genbank:NM_000941.2,HGNC:HGNC:9208,MIM:124015 cytochrome p450 oxidoreductase PORCN 349.768556859235 372.918617574208 326.618496144263 0.875843899317437 -0.191254332079749 0.308927946027229 1 4.17535 4.88845 3.75783 4.41954 GeneID:64840,Genbank:NM_001282167.1,HGNC:HGNC:17652,MIM:300651 porcupine O-acyltransferase hsa04310 Wnt signaling pathway POSTN 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:10631,Genbank:NM_001286667.1,HGNC:HGNC:16953,MIM:608777 periostin GO:0001501,GO:0001666,GO:0001953,GO:0003073,GO:0005578,GO:0005615,GO:0005802,GO:0007155,GO:0008201,GO:0008593,GO:0009612,GO:0014850,GO:0014911,GO:0030198,GO:0031012,GO:0031594,GO:0032355,GO:0044344,GO:0046872,GO:0071307,GO:0071356,GO:0071560,GO:1900025,GO:1904209,GO:1990138,GO:1990523 skeletal system development|response to hypoxia|negative regulation of cell-matrix adhesion|regulation of systemic arterial blood pressure|proteinaceous extracellular matrix|extracellular space|trans-Golgi network|cell adhesion|heparin binding|regulation of Notch signaling pathway|response to mechanical stimulus|response to muscle activity|positive regulation of smooth muscle cell migration|extracellular matrix organization|extracellular matrix|neuromuscular junction|response to estradiol|cellular response to fibroblast growth factor stimulus|metal ion binding|cellular response to vitamin K|cellular response to tumor necrosis factor|cellular response to transforming growth factor beta stimulus|negative regulation of substrate adhesion-dependent cell spreading|positive regulation of chemokine (C-C motif) ligand 2 secretion|neuron projection extension|bone regeneration POT1 280.746816428026 281.362526303298 280.131106552753 0.995623369726155 -0.00632800057450497 1 1 2.46291 2.07219 2.53502 2.03353 GeneID:25913,Genbank:XM_011516007.1,HGNC:HGNC:17284,MIM:606478 protection of telomeres 1 GO:0000781,GO:0000783,GO:0000784,GO:0005634,GO:0005654,GO:0007004,GO:0010521,GO:0016233,GO:0017151,GO:0032202,GO:0032210,GO:0032211,GO:0032212,GO:0032508,GO:0042162,GO:0043047,GO:0051096,GO:0051973,GO:0051974,GO:0060383,GO:0061820,GO:0061821,GO:0070187,GO:0070200,GO:0098505,GO:1905773,GO:1905774,GO:1905776,GO:1990955 chromosome, telomeric region|nuclear telomere cap complex|nuclear chromosome, telomeric region|nucleus|nucleoplasm|telomere maintenance via telomerase|telomerase inhibitor activity|telomere capping|DEAD/H-box RNA helicase binding|telomere assembly|regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance via telomerase|DNA duplex unwinding|telomeric DNA binding|single-stranded telomeric DNA binding|positive regulation of helicase activity|positive regulation of telomerase activity|negative regulation of telomerase activity|positive regulation of DNA strand elongation|telomeric D-loop disassembly|telomeric D-loop binding|shelterin complex|establishment of protein localization to telomere|G-rich strand telomeric DNA binding|8-hydroxy-2'-deoxyguanosine DNA binding|regulation of DNA helicase activity|positive regulation of DNA helicase activity|G-rich single-stranded DNA binding POTEE 1.02229600717608 1.07619535328461 0.968396661067546 0.899833527539349 -0.152269972565186 1 1 0.0171891 0 0 0.0151488 GeneID:445582,Genbank:XM_017004161.2,HGNC:HGNC:33895,MIM:608914 POTE ankyrin domain family member E GO:0001895,GO:0005615,GO:0021762,GO:0070062,GO:0072562 retina homeostasis|extracellular space|substantia nigra development|extracellular exosome|blood microparticle POTEF 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00809444 0 GeneID:728378,Genbank:NM_001099771.2,HGNC:HGNC:33905 POTE ankyrin domain family member F GO:0001895,GO:0005615,GO:0005938,GO:0070062,GO:0072562 retina homeostasis|extracellular space|cell cortex|extracellular exosome|blood microparticle POTEJ 1.48378615844747 1.02816907859967 1.93940323829528 1.88626878464064 0.915535268080234 0.868235938463046 1 0.00914828 0.00844626 0.0260818 0.0080701 GeneID:653781,Genbank:XM_017004741.2,HGNC:HGNC:37094 POTE ankyrin domain family member J GO:0001895,GO:0005615,GO:0070062 retina homeostasis|extracellular space|extracellular exosome POU2F1 111.545677802506 122.265876459098 100.825479145913 0.824641200520426 -0.278161552286635 0.401678041453689 1 0.32646 0.390099 0.368537 0.217701 GeneID:5451,Genbank:NM_002697.3,HGNC:HGNC:9212,MIM:164175 POU class 2 homeobox 1 GO:0000979,GO:0000983,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005783,GO:0019221,GO:0042795,GO:0043231,GO:0043565,GO:0045892,GO:0045944,GO:0090575 RNA polymerase II core promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|endoplasmic reticulum|cytokine-mediated signaling pathway|snRNA transcription from RNA polymerase II promoter|intracellular membrane-bounded organelle|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor complex POU2F2 5.72956635429096 6.61105959887042 4.84807310971151 0.733327696900488 -0.447470065632536 0.768758567530756 1 0.00794814 0.021451 0.0260746 0.0104528 GeneID:5452,Genbank:NM_001247994.1,HGNC:HGNC:9213,MIM:164176 POU class 2 homeobox 2 GO:0000978,GO:0001077,GO:0002335,GO:0002380,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006366,GO:0006959,GO:0019904,GO:0042795,GO:0043231,GO:0043565,GO:0048469 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|mature B cell differentiation|immunoglobulin secretion involved in immune response|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|transcription from RNA polymerase II promoter|humoral immune response|protein domain specific binding|snRNA transcription from RNA polymerase II promoter|intracellular membrane-bounded organelle|sequence-specific DNA binding|cell maturation POU2F3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00691261 0 0 0 GeneID:25833,Genbank:NM_001244682.1,HGNC:HGNC:19864,MIM:607394 POU class 2 homeobox 3 GO:0000978,GO:0001077,GO:0005634,GO:0006357,GO:0008544,GO:0043565,GO:0043922,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|regulation of transcription from RNA polymerase II promoter|epidermis development|sequence-specific DNA binding|negative regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter hsa05168 Herpes simplex infection POU3F1 1.21473732012632 0.490071401957362 1.93940323829528 3.95738912850095 1.98454893191584 0.683483673443307 1 0 0.0214807 0.0696612 0.0216852 GeneID:5453,Genbank:NM_002699.3,HGNC:HGNC:9214,MIM:602479 POU class 3 homeobox 1 GO:0001105,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0008366,GO:0010628,GO:0022011,GO:0030216,GO:0030900,GO:0043565,GO:0045893 RNA polymerase II transcription coactivator activity|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|axon ensheathment|positive regulation of gene expression|myelination in peripheral nervous system|keratinocyte differentiation|forebrain development|sequence-specific DNA binding|positive regulation of transcription, DNA-templated POU3F2 3021.29407480932 2838.89049587326 3203.69765374538 1.12850342709675 0.174410799786268 0.256391962903991 1 34.5644 32.2875 43.1076 33.2491 GeneID:5454,Genbank:NM_005604.3,HGNC:HGNC:9215,MIM:600494 POU class 3 homeobox 2 GO:0000978,GO:0001077,GO:0001105,GO:0003700,GO:0005634,GO:0005667,GO:0006357,GO:0007399,GO:0008284,GO:0008544,GO:0010629,GO:0014002,GO:0021799,GO:0021869,GO:0021979,GO:0021985,GO:0022011,GO:0030182,GO:0040018,GO:0042802,GO:0048663,GO:0048665,GO:0048666,GO:0050770,GO:0071310 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription coactivator activity|DNA binding transcription factor activity|nucleus|transcription factor complex|regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of cell proliferation|epidermis development|negative regulation of gene expression|astrocyte development|cerebral cortex radially oriented cell migration|forebrain ventricular zone progenitor cell division|hypothalamus cell differentiation|neurohypophysis development|myelination in peripheral nervous system|neuron differentiation|positive regulation of multicellular organism growth|identical protein binding|neuron fate commitment|neuron fate specification|neuron development|regulation of axonogenesis|cellular response to organic substance POU3F3 278.496961367658 279.315996801207 277.677925934109 0.994135420506317 -0.00848570669570517 0.993247759373109 1 3.42718 2.91362 3.10113 3.32272 GeneID:5455,Genbank:NM_006236.2,HGNC:HGNC:9216,MIM:602480 POU class 3 homeobox 3 GO:0003700,GO:0005634,GO:0006351,GO:0007417,GO:0007588,GO:0008284,GO:0010628,GO:0021799,GO:0021869,GO:0043066,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0048878,GO:0071837,GO:0072218,GO:0072227,GO:0072233,GO:0072236,GO:0072240 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|central nervous system development|excretion|positive regulation of cell proliferation|positive regulation of gene expression|cerebral cortex radially oriented cell migration|forebrain ventricular zone progenitor cell division|negative regulation of apoptotic process|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|chemical homeostasis|HMG box domain binding|metanephric ascending thin limb development|metanephric macula densa development|metanephric thick ascending limb development|metanephric loop of Henle development|metanephric DCT cell differentiation POU4F2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0152639 0 0 GeneID:5458,Genbank:NM_004575.2,HGNC:HGNC:9219,MIM:113725 POU class 4 homeobox 2 GO:0000122,GO:0000165,GO:0000978,GO:0000981,GO:0001077,GO:0001078,GO:0003713,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0007283,GO:0007411,GO:0007605,GO:0016607,GO:0030182,GO:0030520,GO:0031290,GO:0043068,GO:0043433,GO:0045596,GO:0045597,GO:0045672,GO:0045773,GO:0045944,GO:0048675,GO:0050885,GO:0051090,GO:0060041,GO:0071345,GO:0071392,GO:0072332,GO:0090259,GO:1901796,GO:1902870,GO:1990791,GO:1990841,GO:2000679 negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcription coactivator activity|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|plasma membrane|spermatogenesis|axon guidance|sensory perception of sound|nuclear speck|neuron differentiation|intracellular estrogen receptor signaling pathway|retinal ganglion cell axon guidance|positive regulation of programmed cell death|negative regulation of DNA binding transcription factor activity|negative regulation of cell differentiation|positive regulation of cell differentiation|positive regulation of osteoclast differentiation|positive regulation of axon extension|positive regulation of transcription from RNA polymerase II promoter|axon extension|neuromuscular process controlling balance|regulation of DNA binding transcription factor activity|retina development in camera-type eye|cellular response to cytokine stimulus|cellular response to estradiol stimulus|intrinsic apoptotic signaling pathway by p53 class mediator|regulation of retinal ganglion cell axon guidance|regulation of signal transduction by p53 class mediator|negative regulation of amacrine cell differentiation|dorsal root ganglion development|promoter-specific chromatin binding|positive regulation of transcription regulatory region DNA binding POU4F3 2.51152025102044 3.084507235799 1.93853326624189 0.628474215830372 -0.670074537921313 0.833675698800589 1 0.167237 0.0934458 0.101305 0.0949147 GeneID:5459,Genbank:NM_002700.2,HGNC:HGNC:9220,MIM:602460 POU class 4 homeobox 3 POU5F1 1.75240001074193 1.56626675524197 1.93853326624189 1.2376775921177 0.307635549745768 1 1 0.0419317 0 0.0198221 0 GeneID:5460,Genbank:NM_002701.5,HGNC:HGNC:9221,MIM:164177 POU class 5 homeobox 1 hsa04550 Signaling pathways regulating pluripotency of stem cells POU5F1B 2.93594616402209 1.02816907859967 4.84372324944452 4.71101820727921 2.23603890778607 0.285782096837 1 0 0.0269654 0.0564183 0.210802 GeneID:5462,Genbank:NM_001159542.1,HGNC:HGNC:9223,MIM:615739 POU class 5 homeobox 1B GO:0003700,GO:0005654,GO:0005739,GO:0005829,GO:0006351,GO:0006355,GO:0043565 DNA binding transcription factor activity|nucleoplasm|mitochondrion|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|sequence-specific DNA binding hsa04550 Signaling pathways regulating pluripotency of stem cells POU5F2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.037803 0 0 0 GeneID:134187,Genbank:NM_153216.1,HGNC:HGNC:26367 POU domain class 5, transcription factor 2 GO:0003677,GO:0003700,GO:0005634,GO:0006351 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated POU6F1 366.189685416525 311.21866420312 421.160706629931 1.35326301109967 0.43644225907323 0.0218129904306324 0.600929980812952 0.821887 0.917412 1.25093 1.13815 GeneID:5463,Genbank:XM_017019510.2,HGNC:HGNC:9224 POU class 6 homeobox 1 GO:0003677,GO:0003700,GO:0005634,GO:0006351 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated PPA1 3562.56003476496 3825.19483390016 3299.92523562975 0.862681609413643 -0.213099893854119 0.116051153886982 1 113.088 113.136 104.928 90.8371 GeneID:5464,Genbank:NM_021129.3,HGNC:HGNC:9226,MIM:179030 pyrophosphatase (inorganic) 1 GO:0000287,GO:0004427,GO:0005737,GO:0005829,GO:0006418,GO:0006796,GO:0070062,GO:0071344 magnesium ion binding|inorganic diphosphatase activity|cytoplasm|cytosol|tRNA aminoacylation for protein translation|phosphate-containing compound metabolic process|extracellular exosome|diphosphate metabolic process hsa00190 Oxidative phosphorylation PPA2 1116.36679615302 1132.67773172957 1100.05586057648 0.971199335663396 -0.0421606601506993 0.789235755176177 1 24.5839 25.4618 23.5442 24.5136 GeneID:27068,Genbank:NM_176867.3,HGNC:HGNC:28883,MIM:609988 pyrophosphatase (inorganic) 2 GO:0000287,GO:0004427,GO:0004722,GO:0005759,GO:0006418,GO:0051881,GO:0070062,GO:0071344 magnesium ion binding|inorganic diphosphatase activity|protein serine/threonine phosphatase activity|mitochondrial matrix|tRNA aminoacylation for protein translation|regulation of mitochondrial membrane potential|extracellular exosome|diphosphate metabolic process hsa00190 Oxidative phosphorylation PPAN 135.020878376784 145.500129104087 124.54162764948 0.855955444275835 -0.224392394049823 0.418867259928161 1 16.7766 17.5911 15.0633 15.4794 GeneID:56342,Genbank:NM_001346141.1,HGNC:HGNC:9227,MIM:607793 peter pan homolog (Drosophila) GO:0000027,GO:0003723,GO:0005634,GO:0005730,GO:0019843,GO:0030687 ribosomal large subunit assembly|RNA binding|nucleus|nucleolus|rRNA binding|preribosome, large subunit precursor PPARA 345.042444270215 327.563508256237 362.521380284194 1.10672089883898 0.146291438353185 0.452675940941405 1 0.922077 0.975593 1.22178 1.02136 GeneID:5465,Genbank:XM_006724269.3,HGNC:HGNC:9232,MIM:170998 peroxisome proliferator activated receptor alpha hsa03320,hsa04024,hsa04920,hsa04922,hsa04931,hsa04932,hsa05160 PPAR signaling pathway|cAMP signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hepatitis C PPARD 2262.52789542957 2411.74171681948 2113.31407403967 0.876260529600423 -0.190568219489019 0.167966480064229 1 14.8577 14.8538 12.5645 13.8672 GeneID:5467,Genbank:NM_001171818.1,HGNC:HGNC:9235,MIM:600409 peroxisome proliferator activated receptor delta hsa03320,hsa04310,hsa05200,hsa05221 PPAR signaling pathway|Wnt signaling pathway|Pathways in cancer|Acute myeloid leukemia PPARG 1.21767385583812 0.980142803914724 1.45520490776151 1.48468662112232 0.570158447616103 1 1 0 0.0037364 0.00752036 0 GeneID:5468,Genbank:NM_001354666.1,HGNC:HGNC:9236,MIM:601487 peroxisome proliferator activated receptor gamma GO:0001046,GO:0003677,GO:0003682,GO:0003700,GO:0003707,GO:0004879,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0008270,GO:0010742,GO:0030374,GO:0032526,GO:0042752,GO:0044212,GO:0045600,GO:0045893,GO:0045944,GO:0048511,GO:0050872,GO:0060850 core promoter sequence-specific DNA binding|DNA binding|chromatin binding|DNA binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|macrophage derived foam cell differentiation|ligand-dependent nuclear receptor transcription coactivator activity|response to retinoic acid|regulation of circadian rhythm|transcription regulatory region DNA binding|positive regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|rhythmic process|white fat cell differentiation|regulation of transcription involved in cell fate commitment hsa03320,hsa04152,hsa04211,hsa04380,hsa04714,hsa05016,hsa05200,hsa05202,hsa05216 PPAR signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Osteoclast differentiation|Thermogenesis|Huntington disease|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer PPARGC1A 206.044729752253 186.194655775909 225.894803728597 1.21321851471649 0.278839419960516 0.531354801555359 1 0.568385 0.503514 0.878647 0.451008 GeneID:10891,Genbank:NM_001354827.1,HGNC:HGNC:9237,MIM:604517 PPARG coactivator 1 alpha hsa04152,hsa04211,hsa04371,hsa04714,hsa04910,hsa04920,hsa04922,hsa04931,hsa05016 AMPK signaling pathway|Longevity regulating pathway|Apelin signaling pathway|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Huntington disease PPARGC1B 78.7722639093748 88.7205070627889 68.8240207559607 0.775739713787399 -0.366355432964237 0.269246366600187 1 0.256616 0.252783 0.230615 0.17309 GeneID:133522,Genbank:NM_133263.3,HGNC:HGNC:30022,MIM:608886 PPARG coactivator 1 beta GO:0001104,GO:0001503,GO:0003723,GO:0005634,GO:0005654,GO:0005739,GO:0006355,GO:0006390,GO:0007015,GO:0008134,GO:0010694,GO:0016592,GO:0030331,GO:0030374,GO:0030520,GO:0034614,GO:0042327,GO:0045672,GO:0045780,GO:0045892,GO:0045944,GO:0050682,GO:0051091,GO:0051384,GO:0051591,GO:0060346 RNA polymerase II transcription cofactor activity|ossification|RNA binding|nucleus|nucleoplasm|mitochondrion|regulation of transcription, DNA-templated|transcription from mitochondrial promoter|actin filament organization|transcription factor binding|positive regulation of alkaline phosphatase activity|mediator complex|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|intracellular estrogen receptor signaling pathway|cellular response to reactive oxygen species|positive regulation of phosphorylation|positive regulation of osteoclast differentiation|positive regulation of bone resorption|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|AF-2 domain binding|positive regulation of DNA binding transcription factor activity|response to glucocorticoid|response to cAMP|bone trabecula formation hsa04931 Insulin resistance PPAT 668.023187887288 761.699782452974 574.346593321603 0.75403276533962 -0.407300879926664 0.0410470956662955 0.759435523043776 8.90485 8.19413 7.50236 5.45278 GeneID:5471,Genbank:NM_002703.4,HGNC:HGNC:9238,MIM:172450 phosphoribosyl pyrophosphate amidotransferase GO:0000082,GO:0001822,GO:0004044,GO:0005829,GO:0006164,GO:0006189,GO:0006543,GO:0007595,GO:0009113,GO:0009116,GO:0009168,GO:0031100,GO:0032869,GO:0035690,GO:0046872,GO:0051289,GO:0051539,GO:0060135 G1/S transition of mitotic cell cycle|kidney development|amidophosphoribosyltransferase activity|cytosol|purine nucleotide biosynthetic process|'de novo' IMP biosynthetic process|glutamine catabolic process|lactation|purine nucleobase biosynthetic process|nucleoside metabolic process|purine ribonucleoside monophosphate biosynthetic process|animal organ regeneration|cellular response to insulin stimulus|cellular response to drug|metal ion binding|protein homotetramerization|4 iron, 4 sulfur cluster binding|maternal process involved in female pregnancy hsa00230,hsa00250 Purine metabolism|Alanine, aspartate and glutamate metabolism PPCDC 325.021352033723 326.804896516386 323.23780755106 0.989084958630212 -0.0158336465721226 0.916534752516374 1 1.30287 1.58646 1.57373 1.61976 GeneID:60490,Genbank:XM_017022464.1,HGNC:HGNC:28107,MIM:609854 phosphopantothenoylcysteine decarboxylase GO:0004633,GO:0005829,GO:0009108,GO:0015937,GO:0042802 phosphopantothenoylcysteine decarboxylase activity|cytosol|coenzyme biosynthetic process|coenzyme A biosynthetic process|identical protein binding hsa00770 Pantothenate and CoA biosynthesis PPCS 523.660304246684 535.080157343991 512.240451149377 0.957315355688044 -0.062933844007862 0.739364551996119 1 9.14454 8.38491 8.42955 8.40054 GeneID:79717,Genbank:NM_001287507.1,HGNC:HGNC:25686,MIM:609853 phosphopantothenoylcysteine synthetase GO:0004632,GO:0005829,GO:0009108,GO:0015937,GO:0070062 phosphopantothenate--cysteine ligase activity|cytosol|coenzyme biosynthetic process|coenzyme A biosynthetic process|extracellular exosome hsa00770 Pantothenate and CoA biosynthesis PPDPF 1834.68252103461 1683.88628706689 1985.47875500233 1.17910500860529 0.237692207416885 0.129167905598016 1 118.554 129.415 146.198 146.017 GeneID:79144,Genbank:NM_024299.3,HGNC:HGNC:16142 pancreatic progenitor cell differentiation and proliferation factor GO:0001708,GO:0031017 cell fate specification|exocrine pancreas development PPEF1 3.70431099746269 4.01662376502878 3.3919982298966 0.844489907028247 -0.24384791421394 0.953363825578762 1 0.0200175 0.0382292 0.0288454 0.0268908 GeneID:5475,Genbank:XM_017029612.1,HGNC:HGNC:9243,MIM:300109 protein phosphatase with EF-hand domain 1 GO:0004722,GO:0005506,GO:0005509,GO:0005829,GO:0006470,GO:0022400,GO:0030145,GO:0050906 protein serine/threonine phosphatase activity|iron ion binding|calcium ion binding|cytosol|protein dephosphorylation|regulation of rhodopsin mediated signaling pathway|manganese ion binding|detection of stimulus involved in sensory perception PPFIA1 1487.31298277172 1586.14933866756 1388.47662687588 0.875375724736152 -0.192025718093821 0.184163836631068 1 6.376 6.555 5.95493 5.46091 GeneID:8500,Genbank:XM_011545309.2,HGNC:HGNC:9245,MIM:611054 PTPRF interacting protein alpha 1 GO:0004871,GO:0005737,GO:0005829,GO:0005925,GO:0007160,GO:0007165,GO:0007269,GO:0014047,GO:0048786,GO:0051497,GO:1903077 signal transducer activity|cytoplasm|cytosol|focal adhesion|cell-matrix adhesion|signal transduction|neurotransmitter secretion|glutamate secretion|presynaptic active zone|negative regulation of stress fiber assembly|negative regulation of protein localization to plasma membrane PPFIA2 73.2703797131886 64.6207644726162 81.9199949537609 1.26770389707283 0.342217808481594 0.427227753355165 1 0.238408 0.166715 0.333654 0.159213 GeneID:8499,Genbank:NM_003625.4,HGNC:HGNC:9246,MIM:603143 PTPRF interacting protein alpha 2 GO:0005737,GO:0005829,GO:0007160,GO:0007269,GO:0009986,GO:0014047,GO:0048786,GO:0070062 cytoplasm|cytosol|cell-matrix adhesion|neurotransmitter secretion|cell surface|glutamate secretion|presynaptic active zone|extracellular exosome PPFIA3 263.677684429788 266.641783935216 260.713584924359 0.977767179159371 -0.0324371158643981 0.894564325206593 1 2.06515 1.79459 1.71254 1.92154 GeneID:8541,Genbank:NM_003660.3,HGNC:HGNC:9247,MIM:603144 PTPRF interacting protein alpha 3 GO:0001669,GO:0005829,GO:0007269,GO:0014047,GO:0048172,GO:0048786,GO:0098875 acrosomal vesicle|cytosol|neurotransmitter secretion|glutamate secretion|regulation of short-term neuronal synaptic plasticity|presynaptic active zone|epididymosome PPFIA4 29.0921151936285 26.6843697689064 31.4998606183505 1.18046110480208 0.239350506764699 0.671739259993084 1 0.149004 0.125779 0.150485 0.172611 GeneID:8497,Genbank:XM_006711586.2,HGNC:HGNC:9248,MIM:603145 PTPRF interacting protein alpha 4 GO:0005622,GO:0005829,GO:0007269,GO:0009986,GO:0014047,GO:0045202,GO:0048786 intracellular|cytosol|neurotransmitter secretion|cell surface|glutamate secretion|synapse|presynaptic active zone PPFIBP1 1706.26314203421 1731.67787673612 1680.84840733231 0.970647272170729 -0.0429809713754599 0.771073997223446 1 7.36605 7.44866 8.2217 6.25705 GeneID:8496,Genbank:NM_177444.2,HGNC:HGNC:9249,MIM:603141 PPFIA binding protein 1 GO:0005829,GO:0005886,GO:0005925,GO:0007155,GO:0045296 cytosol|plasma membrane|focal adhesion|cell adhesion|cadherin binding PPFIBP2 8.30301145212334 8.36943145285216 8.23659145139452 0.984127953946935 -0.0230821913923007 1 1 0.0457429 0.015306 0.0157835 0.0184022 GeneID:8495,Genbank:NM_001351862.1,HGNC:HGNC:9250,MIM:603142 PPFIA binding protein 2 GO:0005615,GO:0005622,GO:0005829,GO:0042802 extracellular space|intracellular|cytosol|identical protein binding PPHLN1 870.471851857694 935.008502953938 805.93520076145 0.861954942885855 -0.214315637839901 0.183020183112646 1 5.88832 4.91518 4.45363 4.44654 GeneID:51535,Genbank:XM_017019449.1,HGNC:HGNC:19369,MIM:608150 periphilin 1 GO:0003723,GO:0005654,GO:0005694,GO:0005794,GO:0005829,GO:0006351,GO:0031424,GO:0045892 RNA binding|nucleoplasm|chromosome|Golgi apparatus|cytosol|transcription, DNA-templated|keratinization|negative regulation of transcription, DNA-templated PPIA 56068.4391516753 57851.8388432098 54285.0394601408 0.938345963509722 -0.0918081595486429 0.470002989894132 1 517.014 554.108 498.365 545.398 GeneID:5478,Genbank:NM_001300981.1,HGNC:HGNC:9253,MIM:123840 peptidylprolyl isomerase A hsa04217 Necroptosis PPIAL4A 1.48922424384437 2.00831188251439 0.97013660517434 0.483060730567275 -1.04972351828911 0.81262307337585 1 0.0881459 0.161964 0.165655 0 GeneID:653505,Genbank:NM_001143883.3,HGNC:HGNC:24369 peptidylprolyl isomerase A like 4A GO:0003755,GO:0005737,GO:0006457,GO:0070062 peptidyl-prolyl cis-trans isomerase activity|cytoplasm|protein folding|extracellular exosome PPIB 12539.2704875214 12106.1220655743 12972.4189094684 1.07155857500872 0.0997107147506947 0.451093811102828 1 441.222 458.499 479.005 501.163 GeneID:5479,Genbank:NM_000942.4,HGNC:HGNC:9255,MIM:123841 peptidylprolyl isomerase B PPIC 938.915870308299 880.96841257139 996.863328045208 1.13155399651111 0.178305430066684 0.244754291407359 1 32.6887 32.5684 38.1234 37.4962 GeneID:5480,Genbank:NM_000943.4,HGNC:HGNC:9256,MIM:123842 peptidylprolyl isomerase C PPID 589.783599800861 634.342103876417 545.225095725305 0.859512702047483 -0.218409134595886 0.198215478526781 1 13.311 13.7902 12.7848 11.1919 GeneID:5481,Genbank:NM_005038.2,HGNC:HGNC:9257,MIM:601753 peptidylprolyl isomerase D hsa04217,hsa04218 Necroptosis|Cellular senescence PPIE 1284.18947814183 1300.66432739476 1267.71462888891 0.974667023757123 -0.037018660868013 0.797228593832813 1 5.0238 5.20562 4.80483 5.22177 GeneID:10450,Genbank:XM_024450277.1,HGNC:HGNC:9258,MIM:602435 peptidylprolyl isomerase E GO:0000398,GO:0003723,GO:0003755,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006283,GO:0006355,GO:0006457,GO:0016018,GO:0016607,GO:0034774,GO:0043312,GO:0045070,GO:0071013,GO:1904813 mRNA splicing, via spliceosome|RNA binding|peptidyl-prolyl cis-trans isomerase activity|extracellular region|nucleus|nucleoplasm|cytosol|transcription-coupled nucleotide-excision repair|regulation of transcription, DNA-templated|protein folding|cyclosporin A binding|nuclear speck|secretory granule lumen|neutrophil degranulation|positive regulation of viral genome replication|catalytic step 2 spliceosome|ficolin-1-rich granule lumen hsa03040 Spliceosome PPIF 3988.60920586909 4262.53840419827 3714.6800075399 0.871471328887321 -0.19847489393571 0.130341264435867 1 69.7436 78.5296 68.6542 64.715 GeneID:10105,Genbank:NM_005729.3,HGNC:HGNC:9259,MIM:604486 peptidylprolyl isomerase F GO:0002931,GO:0003755,GO:0005739,GO:0005743,GO:0005757,GO:0005759,GO:0006457,GO:0008637,GO:0010849,GO:0010939,GO:0016018,GO:0016020,GO:0032780,GO:0043066,GO:0046902,GO:0070266,GO:0070301,GO:0071243,GO:0071277,GO:0090200,GO:0090201,GO:0090324,GO:1902445,GO:1902686,GO:2000276,GO:2001243 response to ischemia|peptidyl-prolyl cis-trans isomerase activity|mitochondrion|mitochondrial inner membrane|mitochondrial permeability transition pore complex|mitochondrial matrix|protein folding|apoptotic mitochondrial changes|regulation of proton-transporting ATPase activity, rotational mechanism|regulation of necrotic cell death|cyclosporin A binding|membrane|negative regulation of ATPase activity|negative regulation of apoptotic process|regulation of mitochondrial membrane permeability|necroptotic process|cellular response to hydrogen peroxide|cellular response to arsenic-containing substance|cellular response to calcium ion|positive regulation of release of cytochrome c from mitochondria|negative regulation of release of cytochrome c from mitochondria|negative regulation of oxidative phosphorylation|regulation of mitochondrial membrane permeability involved in programmed necrotic cell death|mitochondrial outer membrane permeabilization involved in programmed cell death|negative regulation of oxidative phosphorylation uncoupler activity|negative regulation of intrinsic apoptotic signaling pathway hsa04020,hsa04022,hsa05012,hsa05016,hsa05145 Calcium signaling pathway|cGMP-PKG signaling pathway|Parkinson disease|Huntington disease|Toxoplasmosis PPIG 222.413505908753 231.068485346176 213.75852647133 0.925087322709053 -0.112338541049504 0.783719661975002 1 1.24755 1.03712 1.24581 0.846826 GeneID:9360,Genbank:NM_004792.2,HGNC:HGNC:14650,MIM:606093 peptidylprolyl isomerase G GO:0003723,GO:0003755,GO:0005634,GO:0005654,GO:0005829,GO:0006457,GO:0008380,GO:0016018,GO:0016363,GO:0016607 RNA binding|peptidyl-prolyl cis-trans isomerase activity|nucleus|nucleoplasm|cytosol|protein folding|RNA splicing|cyclosporin A binding|nuclear matrix|nuclear speck PPIH 958.272546612148 1021.4826007625 895.0624924618 0.876238608267699 -0.190604311715632 0.210652189763865 1 3.87326 4.16022 3.35598 3.57778 GeneID:10465,Genbank:XM_005270366.3,HGNC:HGNC:14651,MIM:606095 peptidylprolyl isomerase H GO:0000398,GO:0003755,GO:0005654,GO:0005681,GO:0005737,GO:0006457,GO:0006461,GO:0016018,GO:0016607,GO:0043021,GO:0045070,GO:0046540,GO:0071001 mRNA splicing, via spliceosome|peptidyl-prolyl cis-trans isomerase activity|nucleoplasm|spliceosomal complex|cytoplasm|protein folding|protein complex assembly|cyclosporin A binding|nuclear speck|ribonucleoprotein complex binding|positive regulation of viral genome replication|U4/U6 x U5 tri-snRNP complex|U4/U6 snRNP hsa03040 Spliceosome PPIL1 1687.58085818744 1701.76593790821 1673.39577846666 0.983328988546792 -0.0242539207034689 0.861339230464301 1 35.7686 37.7466 37.0011 36.256 GeneID:51645,Genbank:NM_016059.4,HGNC:HGNC:9260,MIM:601301 peptidylprolyl isomerase like 1 GO:0000398,GO:0003755,GO:0005654,GO:0006457,GO:0070062,GO:0071013,GO:0097718 mRNA splicing, via spliceosome|peptidyl-prolyl cis-trans isomerase activity|nucleoplasm|protein folding|extracellular exosome|catalytic step 2 spliceosome|disordered domain specific binding hsa03040 Spliceosome PPIL2 1196.90509015021 1167.17585196618 1226.63432833424 1.05094217488127 0.0716832912724291 0.649685289016455 1 6.70556 7.00066 7.86427 6.94404 GeneID:23759,Genbank:NM_014337.3,HGNC:HGNC:9261,MIM:607588 peptidylprolyl isomerase like 2 GO:0000209,GO:0003755,GO:0005634,GO:0005654,GO:0005737,GO:0005796,GO:0005886,GO:0006457,GO:0034450,GO:0050900,GO:0061630,GO:0072659 protein polyubiquitination|peptidyl-prolyl cis-trans isomerase activity|nucleus|nucleoplasm|cytoplasm|Golgi lumen|plasma membrane|protein folding|ubiquitin-ubiquitin ligase activity|leukocyte migration|ubiquitin protein ligase activity|protein localization to plasma membrane hsa04120 Ubiquitin mediated proteolysis PPIL3 319.80860955076 340.141668572858 299.475550528663 0.880443586300911 -0.183697527368398 0.352271319981758 1 4.94501 5.13811 4.17761 4.83918 GeneID:53938,Genbank:XM_005246651.3,HGNC:HGNC:9262,MIM:615811 peptidylprolyl isomerase like 3 GO:0000398,GO:0003755,GO:0006457,GO:0071013 mRNA splicing, via spliceosome|peptidyl-prolyl cis-trans isomerase activity|protein folding|catalytic step 2 spliceosome PPIL4 338.313321898269 369.343021935597 307.283621860941 0.831973541155794 -0.265390447110298 0.179887371183131 1 4.62557 3.96386 4.23175 3.19889 GeneID:85313,Genbank:NM_139126.3,HGNC:HGNC:15702,MIM:607609 peptidylprolyl isomerase like 4 GO:0003723,GO:0003755,GO:0005654,GO:0005829,GO:1901407 RNA binding|peptidyl-prolyl cis-trans isomerase activity|nucleoplasm|cytosol|regulation of phosphorylation of RNA polymerase II C-terminal domain PPIL6 27.0634153556351 32.3152865638621 21.8115441474081 0.674960567170083 -0.567124875997894 0.305119154639727 1 0.15703 0.117216 0.123931 0.0801443 GeneID:285755,Genbank:NM_001286361.1,HGNC:HGNC:21557 peptidylprolyl isomerase like 6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity PPIP5K1 580.150345736193 546.303773314325 613.996918158061 1.12391117936648 0.168528026527921 0.310985653904269 1 2.22772 2.13156 2.54056 2.59944 GeneID:9677,Genbank:NM_001354396.1,HGNC:HGNC:29023,MIM:610979 diphosphoinositol pentakisphosphate kinase 1 GO:0000827,GO:0000828,GO:0000829,GO:0000832,GO:0005524,GO:0005654,GO:0005829,GO:0005886,GO:0006020,GO:0032958,GO:0033857,GO:0043647,GO:0052723,GO:0052724,GO:0102092 inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|ATP binding|nucleoplasm|cytosol|plasma membrane|inositol metabolic process|inositol phosphate biosynthetic process|diphosphoinositol-pentakisphosphate kinase activity|inositol phosphate metabolic process|inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|5-diphosphoinositol pentakisphosphate 3-kinase activity hsa04070 Phosphatidylinositol signaling system PPIP5K2 264.995776289354 252.256208489074 277.735344089633 1.10100498914643 0.138821006414097 0.691700322749442 1 1.18304 0.908003 1.40869 0.989606 GeneID:23262,Genbank:NM_001281471.2,HGNC:HGNC:29035,MIM:611648 diphosphoinositol pentakisphosphate kinase 2 GO:0000827,GO:0000828,GO:0000829,GO:0000832,GO:0005524,GO:0005829,GO:0006020,GO:0032958,GO:0033857,GO:0043647,GO:0052723,GO:0052724,GO:0102092 inositol-1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate kinase activity|inositol heptakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity|ATP binding|cytosol|inositol metabolic process|inositol phosphate biosynthetic process|diphosphoinositol-pentakisphosphate kinase activity|inositol phosphate metabolic process|inositol hexakisphosphate 1-kinase activity|inositol hexakisphosphate 3-kinase activity|5-diphosphoinositol pentakisphosphate 3-kinase activity hsa04070 Phosphatidylinositol signaling system PPL 118.73321304277 126.012942885379 111.453483200161 0.884460601015714 -0.17713021651118 0.559777248301523 1 0.652625 0.48728 0.452351 0.537847 GeneID:5493,Genbank:NM_002705.4,HGNC:HGNC:9273,MIM:602871 periplakin GO:0001533,GO:0005200,GO:0005634,GO:0005739,GO:0005829,GO:0005856,GO:0009612,GO:0030057,GO:0045296,GO:0070062,GO:0070268 cornified envelope|structural constituent of cytoskeleton|nucleus|mitochondrion|cytosol|cytoskeleton|response to mechanical stimulus|desmosome|cadherin binding|extracellular exosome|cornification PPM1A 628.154540996191 645.651963741014 610.657118251369 0.945799211564573 -0.0803941557479731 0.639451476578307 1 1.90998 1.97565 1.96341 1.64126 GeneID:5494,Genbank:NM_177952.2,HGNC:HGNC:9275,MIM:606108 protein phosphatase, Mg2+/Mn2+ dependent 1A GO:0000122,GO:0000287,GO:0004722,GO:0004871,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006470,GO:0006499,GO:0007050,GO:0010991,GO:0016020,GO:0016055,GO:0016311,GO:0030145,GO:0030177,GO:0030512,GO:0030514,GO:0033192,GO:0035970,GO:0042347,GO:0043123,GO:0043124,GO:0045893,GO:0046827,GO:0070412,GO:0071560 negative regulation of transcription from RNA polymerase II promoter|magnesium ion binding|protein serine/threonine phosphatase activity|signal transducer activity|nucleus|nucleoplasm|cytosol|plasma membrane|protein dephosphorylation|N-terminal protein myristoylation|cell cycle arrest|negative regulation of SMAD protein complex assembly|membrane|Wnt signaling pathway|dephosphorylation|manganese ion binding|positive regulation of Wnt signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|calmodulin-dependent protein phosphatase activity|peptidyl-threonine dephosphorylation|negative regulation of NF-kappaB import into nucleus|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription, DNA-templated|positive regulation of protein export from nucleus|R-SMAD binding|cellular response to transforming growth factor beta stimulus hsa04010 MAPK signaling pathway PPM1B 572.260714898731 606.984349261067 537.537080536395 0.88558639311011 -0.175295039370626 0.530365045659337 1 3.10294 2.71471 3.10427 2.05781 GeneID:5495,Genbank:NM_177968.3,HGNC:HGNC:9276,MIM:603770 protein phosphatase, Mg2+/Mn2+ dependent 1B GO:0000287,GO:0004722,GO:0005730,GO:0005829,GO:0006470,GO:0006499,GO:0016020,GO:0030145,GO:0032688,GO:0035970,GO:0042347,GO:0043124,GO:0050687 magnesium ion binding|protein serine/threonine phosphatase activity|nucleolus|cytosol|protein dephosphorylation|N-terminal protein myristoylation|membrane|manganese ion binding|negative regulation of interferon-beta production|peptidyl-threonine dephosphorylation|negative regulation of NF-kappaB import into nucleus|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of defense response to virus hsa04010 MAPK signaling pathway PPM1D 457.88798206998 472.333434584942 443.442529555018 0.938833665130414 -0.0910585192747951 0.618293685648874 1 4.22063 4.14303 4.115 3.82006 GeneID:8493,Genbank:NM_003620.3,HGNC:HGNC:9277,MIM:605100 protein phosphatase, Mg2+/Mn2+ dependent 1D hsa04115 p53 signaling pathway PPM1E 254.813686067141 268.736339711993 240.89103242229 0.896384287590041 -0.157810734319509 0.486133873187651 1 1.20336 1.09264 1.21864 0.875703 GeneID:22843,Genbank:NM_014906.4,HGNC:HGNC:19322 protein phosphatase, Mg2+/Mn2+ dependent 1E GO:0004722,GO:0005634,GO:0005730,GO:0005739,GO:0006469,GO:0035690,GO:0035970,GO:0043234,GO:0046872,GO:0051496 protein serine/threonine phosphatase activity|nucleus|nucleolus|mitochondrion|negative regulation of protein kinase activity|cellular response to drug|peptidyl-threonine dephosphorylation|protein complex|metal ion binding|positive regulation of stress fiber assembly PPM1F 1269.45673346996 1368.56272120277 1170.35074573716 0.855167781209615 -0.225720594921467 0.120911824673621 1 9.15995 9.80753 8.28456 8.31946 GeneID:9647,Genbank:NM_014634.3,HGNC:HGNC:19388 protein phosphatase, Mg2+/Mn2+ dependent 1F GO:0004722,GO:0005829,GO:0006469,GO:0010628,GO:0010634,GO:0010811,GO:0016576,GO:0033137,GO:0033192,GO:0035690,GO:0035970,GO:0043234,GO:0043280,GO:0044387,GO:0045892,GO:0045927,GO:0046872,GO:0048471,GO:0050921,GO:0051496,GO:0051894,GO:0097193 protein serine/threonine phosphatase activity|cytosol|negative regulation of protein kinase activity|positive regulation of gene expression|positive regulation of epithelial cell migration|positive regulation of cell-substrate adhesion|histone dephosphorylation|negative regulation of peptidyl-serine phosphorylation|calmodulin-dependent protein phosphatase activity|cellular response to drug|peptidyl-threonine dephosphorylation|protein complex|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of protein kinase activity by regulation of protein phosphorylation|negative regulation of transcription, DNA-templated|positive regulation of growth|metal ion binding|perinuclear region of cytoplasm|positive regulation of chemotaxis|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|intrinsic apoptotic signaling pathway PPM1G 5002.20316518065 5095.1700104178 4909.23631994349 0.963507853497696 -0.0536316689932441 0.680269754362134 1 68.666 70.0873 69.4496 67.11 GeneID:5496,Genbank:NM_177983.2,HGNC:HGNC:9278,MIM:605119 protein phosphatase, Mg2+/Mn2+ dependent 1G GO:0004722,GO:0005634,GO:0005654,GO:0005737,GO:0006470,GO:0007050,GO:0016020,GO:0035970,GO:0046872 protein serine/threonine phosphatase activity|nucleus|nucleoplasm|cytoplasm|protein dephosphorylation|cell cycle arrest|membrane|peptidyl-threonine dephosphorylation|metal ion binding PPM1H 104.55692803356 117.999312665537 91.1145434015822 0.772161645210949 -0.373025200330741 0.20381693457368 1 0.557491 0.567459 0.491873 0.402966 GeneID:57460,Genbank:NM_020700.1,HGNC:HGNC:18583,MIM:616016 protein phosphatase, Mg2+/Mn2+ dependent 1H GO:0004721,GO:0004722,GO:0005634,GO:0005654,GO:0005737 phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|nucleus|nucleoplasm|cytoplasm PPM1J 7.92572893555843 5.67894306964064 10.1725148014762 1.79126902255069 0.84098202540512 0.457727377399798 1 0.120586 0.104398 0.0560479 0.286903 GeneID:333926,Genbank:NM_005167.5,HGNC:HGNC:20785,MIM:609957 protein phosphatase, Mg2+/Mn2+ dependent 1J GO:0004722 protein serine/threonine phosphatase activity PPM1K 147.815066232203 166.697660902093 128.932471562314 0.773450994240645 -0.37061820929674 0.242739631398067 1 0.851807 0.748891 0.711068 0.499741 GeneID:152926,Genbank:NM_152542.4,HGNC:HGNC:25415,MIM:611065 protein phosphatase, Mg2+/Mn2+ dependent 1K GO:0004722,GO:0005739,GO:0005759,GO:0009083,GO:0046872 protein serine/threonine phosphatase activity|mitochondrion|mitochondrial matrix|branched-chain amino acid catabolic process|metal ion binding PPM1L 159.675606897907 161.345093100139 158.006120695675 0.979305398507585 -0.0301692573212169 0.981250381102999 1 0.601863 0.382826 0.570516 0.402276 GeneID:151742,Genbank:XM_011512440.3,HGNC:HGNC:16381,MIM:611931 protein phosphatase, Mg2+/Mn2+ dependent 1L GO:0000165,GO:0004722,GO:0005789,GO:0007178,GO:0016021,GO:0030148,GO:0046872,GO:0070062 MAPK cascade|protein serine/threonine phosphatase activity|endoplasmic reticulum membrane|transmembrane receptor protein serine/threonine kinase signaling pathway|integral component of membrane|sphingolipid biosynthetic process|metal ion binding|extracellular exosome PPM1M 303.375021018849 300.033265852363 306.716776185334 1.02227589768749 0.0317846116459403 0.915465674653461 1 4.27851 3.76942 3.54066 4.67532 GeneID:132160,Genbank:XM_005264879.2,HGNC:HGNC:26506,MIM:608979 protein phosphatase, Mg2+/Mn2+ dependent 1M GO:0004721,GO:0005634,GO:0006470,GO:0008420,GO:0030145 phosphoprotein phosphatase activity|nucleus|protein dephosphorylation|CTD phosphatase activity|manganese ion binding PPM1N 45.9122329805967 45.7873457901356 46.0371201710579 1.0054550963069 0.00784865222314622 1 1 0.482686 0.88085 0.869093 0.871542 GeneID:147699,Genbank:NM_001080401.1,HGNC:HGNC:26845 protein phosphatase, Mg2+/Mn2+ dependent 1N (putative) GO:0000287,GO:0004722,GO:0030145 magnesium ion binding|protein serine/threonine phosphatase activity|manganese ion binding PPME1 1639.03347827827 1646.80252265069 1631.26443390585 0.990564692164896 -0.0136768966350305 0.914426124244325 1 21.7982 23.2663 22.8288 21.4621 GeneID:51400,Genbank:NM_001271593.1,HGNC:HGNC:30178,MIM:611117 protein phosphatase methylesterase 1 GO:0000086,GO:0004864,GO:0005654,GO:0006482,GO:0019888,GO:0019901,GO:0019903,GO:0045296,GO:0051721,GO:0051722 G2/M transition of mitotic cell cycle|protein phosphatase inhibitor activity|nucleoplasm|protein demethylation|protein phosphatase regulator activity|protein kinase binding|protein phosphatase binding|cadherin binding|protein phosphatase 2A binding|protein C-terminal methylesterase activity PPOX 337.825393344904 316.561423349966 359.089363339841 1.13434340653333 0.181857462063832 0.360517075087594 1 2.49262 2.50099 2.47891 2.737 GeneID:5498,Genbank:XM_017001571.1,HGNC:HGNC:9280,MIM:600923 protoporphyrinogen oxidase hsa00860 Porphyrin and chlorophyll metabolism PPP1CA 5355.81160918228 5373.7608894479 5337.86232891666 0.993319658006791 -0.0096700319078075 0.923822521851922 1 106.717 113.927 107.873 116.14 GeneID:5499,Genbank:NM_206873.1,HGNC:HGNC:9281,MIM:176875 protein phosphatase 1 catalytic subunit alpha hsa03015,hsa04022,hsa04024,hsa04114,hsa04218,hsa04261,hsa04270,hsa04390,hsa04510,hsa04611,hsa04720,hsa04728,hsa04750,hsa04810,hsa04910,hsa04921,hsa04931,hsa05031,hsa05034,hsa05168,hsa05205 mRNA surveillance pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Hippo signaling pathway|Focal adhesion|Platelet activation|Long-term potentiation|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Oxytocin signaling pathway|Insulin resistance|Amphetamine addiction|Alcoholism|Herpes simplex infection|Proteoglycans in cancer PPP1CB 5383.83511699349 5486.82461577083 5280.84561821614 0.96245934361331 -0.0552024954977003 0.757984537856246 1 57.6235 51.6399 58.4341 48.2375 GeneID:5500,Genbank:NM_206876.1,HGNC:HGNC:9282,MIM:600590 protein phosphatase 1 catalytic subunit beta hsa03015,hsa04022,hsa04024,hsa04114,hsa04218,hsa04261,hsa04270,hsa04390,hsa04510,hsa04611,hsa04720,hsa04728,hsa04750,hsa04810,hsa04910,hsa04921,hsa04931,hsa05031,hsa05034,hsa05168,hsa05205 mRNA surveillance pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Hippo signaling pathway|Focal adhesion|Platelet activation|Long-term potentiation|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Oxytocin signaling pathway|Insulin resistance|Amphetamine addiction|Alcoholism|Herpes simplex infection|Proteoglycans in cancer PPP1CC 3293.71957591154 3308.2726763905 3279.16647543259 0.991201994573896 -0.0127490043025384 0.949302262496327 1 42.1663 38.5445 43.811 37.0342 GeneID:5501,Genbank:XM_011538504.3,HGNC:HGNC:9283,MIM:176914 protein phosphatase 1 catalytic subunit gamma hsa03015,hsa04022,hsa04024,hsa04114,hsa04218,hsa04261,hsa04270,hsa04390,hsa04510,hsa04611,hsa04720,hsa04728,hsa04750,hsa04810,hsa04910,hsa04921,hsa04931,hsa05031,hsa05034,hsa05168,hsa05205 mRNA surveillance pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Oocyte meiosis|Cellular senescence|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Hippo signaling pathway|Focal adhesion|Platelet activation|Long-term potentiation|Dopaminergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|Insulin signaling pathway|Oxytocin signaling pathway|Insulin resistance|Amphetamine addiction|Alcoholism|Herpes simplex infection|Proteoglycans in cancer PPP1R10 2502.32765670968 2549.53599066205 2455.11932275732 0.962967117055597 -0.0544415604435412 0.685201932241524 1 14.7054 15.1549 14.6582 14.2273 GeneID:5514,Genbank:NM_002714.3,HGNC:HGNC:9284,MIM:603771 protein phosphatase 1 regulatory subunit 10 GO:0000785,GO:0003677,GO:0003723,GO:0004864,GO:0005634,GO:0005654,GO:0006606,GO:0016604,GO:0046872,GO:0072357 chromatin|DNA binding|RNA binding|protein phosphatase inhibitor activity|nucleus|nucleoplasm|protein import into nucleus|nuclear body|metal ion binding|PTW/PP1 phosphatase complex PPP1R11 2103.34586529897 2079.20105930451 2127.49067129343 1.02322508050523 0.0331235319954666 0.825867150138257 1 40.7503 43.4269 43.7733 43.4569 GeneID:6992,Genbank:XM_006715174.4,HGNC:HGNC:9285,MIM:606670 protein phosphatase 1 regulatory inhibitor subunit 11 GO:0000164,GO:0004865,GO:0005634,GO:0005737,GO:0008157,GO:0032515,GO:0042787,GO:0050710,GO:0050830,GO:0061630 protein phosphatase type 1 complex|protein serine/threonine phosphatase inhibitor activity|nucleus|cytoplasm|protein phosphatase 1 binding|negative regulation of phosphoprotein phosphatase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of cytokine secretion|defense response to Gram-positive bacterium|ubiquitin protein ligase activity PPP1R12A 481.854616558278 537.664784522725 426.044448593832 0.792397904527118 -0.335703029819393 0.138704100057322 1 2.47311 2.24209 2.18224 1.53401 GeneID:4659,Genbank:NM_001244990.1,HGNC:HGNC:7618,MIM:602021 protein phosphatase 1 regulatory subunit 12A GO:0000086,GO:0000278,GO:0000776,GO:0004857,GO:0004871,GO:0005654,GO:0005813,GO:0005829,GO:0005925,GO:0006470,GO:0007098,GO:0015629,GO:0019208,GO:0019901,GO:0030018,GO:0030155,GO:0031672,GO:0035507,GO:0035508,GO:0035690,GO:0043086,GO:0043292,GO:0045944,GO:0046822,GO:0071889,GO:0072357 G2/M transition of mitotic cell cycle|mitotic cell cycle|kinetochore|enzyme inhibitor activity|signal transducer activity|nucleoplasm|centrosome|cytosol|focal adhesion|protein dephosphorylation|centrosome cycle|actin cytoskeleton|phosphatase regulator activity|protein kinase binding|Z disc|regulation of cell adhesion|A band|regulation of myosin-light-chain-phosphatase activity|positive regulation of myosin-light-chain-phosphatase activity|cellular response to drug|negative regulation of catalytic activity|contractile fiber|positive regulation of transcription from RNA polymerase II promoter|regulation of nucleocytoplasmic transport|14-3-3 protein binding|PTW/PP1 phosphatase complex hsa04022,hsa04024,hsa04270,hsa04510,hsa04611,hsa04810,hsa04921,hsa05205 cGMP-PKG signaling pathway|cAMP signaling pathway|Vascular smooth muscle contraction|Focal adhesion|Platelet activation|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Proteoglycans in cancer PPP1R12B 300.613944017906 308.969203946326 292.258684089486 0.945915257432119 -0.0802171535623067 0.752095910967671 1 0.574217 0.48391 0.566337 0.44457 GeneID:4660,Genbank:XM_017001350.1,HGNC:HGNC:7619,MIM:603768 protein phosphatase 1 regulatory subunit 12B GO:0000086,GO:0005654,GO:0005829,GO:0006937,GO:0007165,GO:0008047,GO:0019208,GO:0019901,GO:0030018,GO:0031672 G2/M transition of mitotic cell cycle|nucleoplasm|cytosol|regulation of muscle contraction|signal transduction|enzyme activator activity|phosphatase regulator activity|protein kinase binding|Z disc|A band hsa04270,hsa04510,hsa04810,hsa04921,hsa05205 Vascular smooth muscle contraction|Focal adhesion|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Proteoglycans in cancer PPP1R12C 2463.8969233836 2322.95458317264 2604.83926359456 1.12134747810563 0.165233403264415 0.238946019288306 1 26.3536 25.7441 29.8428 29.9167 GeneID:54776,Genbank:NM_001271618.1,HGNC:HGNC:14947,MIM:613245 protein phosphatase 1 regulatory subunit 12C GO:0005737,GO:0007165,GO:0019208,GO:0019901 cytoplasm|signal transduction|phosphatase regulator activity|protein kinase binding hsa04270,hsa04510,hsa04810,hsa04921,hsa05205 Vascular smooth muscle contraction|Focal adhesion|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Proteoglycans in cancer PPP1R13B 173.793355979952 163.911119969511 183.675591990392 1.12058042202724 0.16424619217391 0.480794469371584 1 0.850529 0.76869 0.988937 0.901868 GeneID:23368,Genbank:XM_005267487.5,HGNC:HGNC:14950,MIM:606455 protein phosphatase 1 regulatory subunit 13B GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0008134,GO:0042981,GO:0045786,GO:0072332,GO:1900740,GO:1901796 nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|plasma membrane|transcription factor binding|regulation of apoptotic process|negative regulation of cell cycle|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of signal transduction by p53 class mediator PPP1R13L 676.051369946303 677.526222178458 674.576517714147 0.995646361177245 -0.00629468549723791 0.957173634754512 1 8.33953 8.41278 7.93191 8.20439 GeneID:10848,Genbank:NM_001142502.1,HGNC:HGNC:18838,MIM:607463 protein phosphatase 1 regulatory subunit 13 like PPP1R14B 3461.03741576032 3182.35309640537 3739.72173511528 1.17514355630099 0.232837008120312 0.090894853922468 0.980317831934173 134.966 144.719 165.409 172.254 GeneID:26472,Genbank:NM_138689.2,HGNC:HGNC:9057,MIM:601140 protein phosphatase 1 regulatory inhibitor subunit 14B GO:0004864,GO:0005737,GO:0042325,GO:0045087 protein phosphatase inhibitor activity|cytoplasm|regulation of phosphorylation|innate immune response PPP1R14C 456.714917070458 435.107625346399 478.322208794518 1.0993192969526 0.136610477484645 0.433188344664266 1 4.76156 4.35117 5.11659 5.08028 GeneID:81706,Genbank:NM_030949.2,HGNC:HGNC:14952,MIM:613242 protein phosphatase 1 regulatory inhibitor subunit 14C GO:0004865,GO:0005737,GO:0016020,GO:0042325 protein serine/threonine phosphatase inhibitor activity|cytoplasm|membrane|regulation of phosphorylation PPP1R15A 1723.92663805186 1563.63548014285 1884.21779596087 1.20502368991316 0.269061509097796 0.0600173425294093 0.879410748501007 18.4142 18.4642 22.9123 22.4157 GeneID:23645,Genbank:NM_014330.3,HGNC:HGNC:14375,MIM:611048 protein phosphatase 1 regulatory subunit 15A GO:0000164,GO:0005737,GO:0005739,GO:0005741,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0006915,GO:0006974,GO:0007050,GO:0008157,GO:0016020,GO:0019888,GO:0019901,GO:0032058,GO:0032515,GO:0032516,GO:0034976,GO:0035308,GO:0036496,GO:0070059,GO:0070972,GO:0072542,GO:1902310,GO:1903898,GO:1903917 protein phosphatase type 1 complex|cytoplasm|mitochondrion|mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|apoptotic process|cellular response to DNA damage stimulus|cell cycle arrest|protein phosphatase 1 binding|membrane|protein phosphatase regulator activity|protein kinase binding|positive regulation of translational initiation in response to stress|negative regulation of phosphoprotein phosphatase activity|positive regulation of phosphoprotein phosphatase activity|response to endoplasmic reticulum stress|negative regulation of protein dephosphorylation|regulation of translational initiation by eIF2 alpha dephosphorylation|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|protein localization to endoplasmic reticulum|protein phosphatase activator activity|positive regulation of peptidyl-serine dephosphorylation|negative regulation of PERK-mediated unfolded protein response|positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation hsa04141 Protein processing in endoplasmic reticulum PPP1R15B 1773.86695692456 1908.02409519905 1639.70981865006 0.859375844768356 -0.218638868302227 0.221082580290501 1 11.6682 12.1311 12.061 8.59701 GeneID:84919,Genbank:XM_005245551.5,HGNC:HGNC:14951,MIM:613257 protein phosphatase 1 regulatory subunit 15B GO:0000164,GO:0001933,GO:0006983,GO:0019888,GO:0042542,GO:0070262,GO:1903898,GO:1903912 protein phosphatase type 1 complex|negative regulation of protein phosphorylation|ER overload response|protein phosphatase regulator activity|response to hydrogen peroxide|peptidyl-serine dephosphorylation|negative regulation of PERK-mediated unfolded protein response|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation PPP1R16A 701.338485012042 695.630455086411 707.046514937672 1.01641109840403 0.0234840336769016 0.930971374208271 1 8.21482 9.0707 8.7909 9.46133 GeneID:84988,Genbank:NM_032902.6,HGNC:HGNC:14941,MIM:609172 protein phosphatase 1 regulatory subunit 16A GO:0005886,GO:0019888 plasma membrane|protein phosphatase regulator activity PPP1R16B 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.00544054 0.00507798 GeneID:26051,Genbank:NM_015568.3,HGNC:HGNC:15850,MIM:613275 protein phosphatase 1 regulatory subunit 16B GO:0001938,GO:0005634,GO:0005886,GO:0014066,GO:0016607,GO:0019888,GO:0035304,GO:0035307,GO:0035308,GO:0042995,GO:0048471,GO:0051489,GO:0061028,GO:1902309,GO:1903589 positive regulation of endothelial cell proliferation|nucleus|plasma membrane|regulation of phosphatidylinositol 3-kinase signaling|nuclear speck|protein phosphatase regulator activity|regulation of protein dephosphorylation|positive regulation of protein dephosphorylation|negative regulation of protein dephosphorylation|cell projection|perinuclear region of cytoplasm|regulation of filopodium assembly|establishment of endothelial barrier|negative regulation of peptidyl-serine dephosphorylation|positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis PPP1R18 3423.18614762857 3257.30931859035 3589.06297666679 1.10184898811514 0.139926511544092 0.299355961550597 1 28.6589 27.4525 30.9444 31.6228 GeneID:170954,Genbank:NM_133471.3,HGNC:HGNC:29413,MIM:610990 protein phosphatase 1 regulatory subunit 18 GO:0003779,GO:0005737,GO:0005856,GO:0019902 actin binding|cytoplasm|cytoskeleton|phosphatase binding PPP1R1B 1.45302997762802 0 2.90605995525603 Inf Inf 0.254745368186766 1 0 0 0 0.0735638 GeneID:84152,Genbank:XM_017025216.2,HGNC:HGNC:9287,MIM:604399 protein phosphatase 1 regulatory inhibitor subunit 1B hsa04024,hsa04728,hsa05030,hsa05031,hsa05034 cAMP signaling pathway|Dopaminergic synapse|Cocaine addiction|Amphetamine addiction|Alcoholism PPP1R2 1101.35168551815 1188.79479458039 1013.90857645592 0.85288779954139 -0.229572132584259 0.128749685725603 1 11.7429 11.8283 10.9525 9.00533 GeneID:5504,Genbank:NM_001291505.1,HGNC:HGNC:9288,MIM:601792 protein phosphatase 1 regulatory inhibitor subunit 2 GO:0000164,GO:0004865,GO:0005977,GO:0006091,GO:0009966,GO:0043666 protein phosphatase type 1 complex|protein serine/threonine phosphatase inhibitor activity|glycogen metabolic process|generation of precursor metabolites and energy|regulation of signal transduction|regulation of phosphoprotein phosphatase activity PPP1R21 268.899228716637 260.578630668096 277.219826765177 1.06386247427279 0.0893116653990795 0.672896963284679 1 2.40988 2.55443 2.78493 2.38806 GeneID:129285,Genbank:NM_001135629.2,HGNC:HGNC:30595 protein phosphatase 1 regulatory subunit 21 GO:0016020 membrane PPP1R26 662.854402215687 669.521383612869 656.187420818505 0.980084336182943 -0.0290221965188616 0.859858529899175 1 3.37448 3.42462 3.41836 3.30111 GeneID:9858,Genbank:XM_017015358.1,HGNC:HGNC:29089,MIM:614056 protein phosphatase 1 regulatory subunit 26 GO:0004864,GO:0005730,GO:0010923 protein phosphatase inhibitor activity|nucleolus|negative regulation of phosphatase activity PPP1R27 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0 0.073041 0 GeneID:116729,Genbank:NM_001007533.3,HGNC:HGNC:16813 protein phosphatase 1 regulatory subunit 27 GO:0004864,GO:0010923,GO:0019902 protein phosphatase inhibitor activity|negative regulation of phosphatase activity|phosphatase binding PPP1R2B 13.4548284761957 15.2784573549402 11.6311995974513 0.76128101988585 -0.393498985236257 0.634681998469798 1 0.251021 0.361566 0.241636 0.224279 GeneID:153743,Genbank:NM_206858.2,HGNC:HGNC:16318 PPP1R2 family member B GO:0000164,GO:0004864,GO:0005977,GO:0009966,GO:0043666 protein phosphatase type 1 complex|protein phosphatase inhibitor activity|glycogen metabolic process|regulation of signal transduction|regulation of phosphoprotein phosphatase activity PPP1R32 6.04403155113687 7.24520982488261 4.84285327739113 0.66842139764663 -0.581170176891372 0.68843756064575 1 0.0977731 0.0855147 0.0225561 0.0849224 GeneID:220004,Genbank:NM_145017.2,HGNC:HGNC:28869 protein phosphatase 1 regulatory subunit 32 GO:0019902 phosphatase binding PPP1R35 994.26335434857 1000.93883650072 987.58787219642 0.986661558311621 -0.0193727942766302 0.896495164540864 1 48.8588 48.4156 45.7444 54.0951 GeneID:221908,Genbank:NM_001346938.1,HGNC:HGNC:28320 protein phosphatase 1 regulatory subunit 35 GO:0004864,GO:0010923,GO:0019902 protein phosphatase inhibitor activity|negative regulation of phosphatase activity|phosphatase binding PPP1R36 6.28830564653725 7.24520982488261 5.33140146819188 0.735851907267333 -0.442512646741942 0.772608419060652 1 0.129344 0.0980728 0.0492979 0.0687999 GeneID:145376,Genbank:XM_005267355.4,HGNC:HGNC:20097 protein phosphatase 1 regulatory subunit 36 GO:0004864,GO:0010923,GO:0019902 protein phosphatase inhibitor activity|negative regulation of phosphatase activity|phosphatase binding PPP1R37 1090.05246711177 1000.03716293767 1180.06777128587 1.18002391813055 0.238816102145269 0.210678938270738 1 9.60271 11.8694 13.5248 13.2144 GeneID:284352,Genbank:NM_019121.1,HGNC:HGNC:27607 protein phosphatase 1 regulatory subunit 37 GO:0004864,GO:0010923 protein phosphatase inhibitor activity|negative regulation of phosphatase activity PPP1R3B 142.059342739743 130.491229087896 153.627456391589 1.17730101452343 0.235483238505246 0.374259437469028 1 0.885654 1.01223 1.1482 1.04547 GeneID:79660,Genbank:NM_001201329.1,HGNC:HGNC:14942,MIM:610541 protein phosphatase 1 regulatory subunit 3B GO:0000164,GO:0004721,GO:0005977,GO:0005979,GO:0005981,GO:0019888,GO:0019899,GO:0042587,GO:0043231 protein phosphatase type 1 complex|phosphoprotein phosphatase activity|glycogen metabolic process|regulation of glycogen biosynthetic process|regulation of glycogen catabolic process|protein phosphatase regulator activity|enzyme binding|glycogen granule|intracellular membrane-bounded organelle hsa04910,hsa04931 Insulin signaling pathway|Insulin resistance PPP1R3C 169.877604746352 161.912616742105 177.842592750598 1.09838625506168 0.13538547717593 0.574245906714355 1 2.67183 2.59361 2.69141 3.10603 GeneID:5507,Genbank:NM_005398.6,HGNC:HGNC:9293,MIM:602999 protein phosphatase 1 regulatory subunit 3C GO:0004722,GO:0005829,GO:0005977,GO:0005978,GO:0019888,GO:0019903 protein serine/threonine phosphatase activity|cytosol|glycogen metabolic process|glycogen biosynthetic process|protein phosphatase regulator activity|protein phosphatase binding hsa04910,hsa04931 Insulin signaling pathway|Insulin resistance PPP1R3D 113.518415042268 121.371977549446 105.664852535091 0.870586890553413 -0.19993979894714 0.494773854104052 1 2.05184 1.87859 2.10556 1.40308 GeneID:5509,Genbank:NM_006242.3,HGNC:HGNC:9294,MIM:603326 protein phosphatase 1 regulatory subunit 3D GO:0004722,GO:0005977,GO:0005979,GO:0005981,GO:0019899,GO:0042587,GO:0043231 protein serine/threonine phosphatase activity|glycogen metabolic process|regulation of glycogen biosynthetic process|regulation of glycogen catabolic process|enzyme binding|glycogen granule|intracellular membrane-bounded organelle hsa04910,hsa04931 Insulin signaling pathway|Insulin resistance PPP1R3E 188.427504993418 168.937312503779 207.917697483056 1.23073875392925 0.299524556778036 0.211355533717548 1 1.07112 1.19804 1.60366 1.38155 GeneID:90673,Genbank:NM_001276318.1,HGNC:HGNC:14943 protein phosphatase 1 regulatory subunit 3E GO:0005977 glycogen metabolic process hsa04910,hsa04931 Insulin signaling pathway|Insulin resistance PPP1R3F 312.444756958379 323.460640596946 301.428873319812 0.931887331835878 -0.101772555917037 0.599980553046015 1 1.38301 1.47956 1.31278 1.3996 GeneID:89801,Genbank:XM_017029934.1,HGNC:HGNC:14944 protein phosphatase 1 regulatory subunit 3F GO:0005979,GO:0016020,GO:0016021,GO:0019903,GO:2000465,GO:2001069 regulation of glycogen biosynthetic process|membrane|integral component of membrane|protein phosphatase binding|regulation of glycogen (starch) synthase activity|glycogen binding hsa04910 Insulin signaling pathway PPP1R3G 30.3000236046564 30.066843307923 30.5332039013898 1.01551079335768 0.0222055734015131 1 1 0.634826 1.19884 1.34121 1.12667 GeneID:648791,Genbank:NM_001145115.2,HGNC:HGNC:14945 protein phosphatase 1 regulatory subunit 3G PPP1R42 1.73088842308455 2.00831188251439 1.45346496365472 0.723724724386428 -0.466487036088226 0.969067157519303 1 0 0.0271357 0 0.0246222 GeneID:286187,Genbank:NM_001013626.3,HGNC:HGNC:33732,MIM:617720 protein phosphatase 1 regulatory subunit 42 GO:0002177,GO:0003779,GO:0005737,GO:0005813,GO:0005815,GO:0008092,GO:0010921,GO:0015630,GO:0015631,GO:0070840 manchette|actin binding|cytoplasm|centrosome|microtubule organizing center|cytoskeletal protein binding|regulation of phosphatase activity|microtubule cytoskeleton|tubulin binding|dynein complex binding PPP1R7 1274.51941735312 1230.89189187318 1318.14694283306 1.07088766408811 0.0988071495904388 0.497405984763317 1 11.7548 11.2632 12.8577 12.796 GeneID:5510,Genbank:NM_001282412.1,HGNC:HGNC:9295,MIM:602877 protein phosphatase 1 regulatory subunit 7 GO:0005634,GO:0005694,GO:0005737,GO:0007059,GO:0019888,GO:0030234,GO:0035307,GO:0070062 nucleus|chromosome|cytoplasm|chromosome segregation|protein phosphatase regulator activity|enzyme regulator activity|positive regulation of protein dephosphorylation|extracellular exosome PPP1R8 1283.25556367796 1319.08410991443 1247.42701744148 0.945676631281986 -0.0805811483196365 0.590424907057721 1 17.0521 16.8444 16.5584 16.2257 GeneID:5511,Genbank:NM_014110.4,HGNC:HGNC:9296,MIM:602636 protein phosphatase 1 regulatory subunit 8 PPP1R9A 199.621024916391 206.325800875738 192.916248957043 0.935007876563285 -0.0969495764850267 0.722975700237463 1 0.420478 0.41908 0.481878 0.317026 GeneID:55607,Genbank:XM_011516383.1,HGNC:HGNC:14946,MIM:602468 protein phosphatase 1 regulatory subunit 9A GO:0005829,GO:0007015,GO:0007568,GO:0008022,GO:0008157,GO:0010976,GO:0014069,GO:0019722,GO:0019901,GO:0019904,GO:0030054,GO:0030175,GO:0030833,GO:0030864,GO:0031175,GO:0031594,GO:0042803,GO:0043025,GO:0044325,GO:0044326,GO:0045860,GO:0051015,GO:0051020,GO:0051489,GO:0051497,GO:0051823,GO:0051963,GO:0060079,GO:0060999,GO:0061001,GO:0097237,GO:1900272,GO:1900454,GO:1904049,GO:1990761 cytosol|actin filament organization|aging|protein C-terminus binding|protein phosphatase 1 binding|positive regulation of neuron projection development|postsynaptic density|calcium-mediated signaling|protein kinase binding|protein domain specific binding|cell junction|filopodium|regulation of actin filament polymerization|cortical actin cytoskeleton|neuron projection development|neuromuscular junction|protein homodimerization activity|neuronal cell body|ion channel binding|dendritic spine neck|positive regulation of protein kinase activity|actin filament binding|GTPase binding|regulation of filopodium assembly|negative regulation of stress fiber assembly|regulation of synapse structural plasticity|regulation of synapse assembly|excitatory postsynaptic potential|positive regulation of dendritic spine development|regulation of dendritic spine morphogenesis|cellular response to toxic substance|negative regulation of long-term synaptic potentiation|positive regulation of long term synaptic depression|negative regulation of spontaneous neurotransmitter secretion|growth cone lamellipodium PPP1R9B 3166.22423560041 2930.82505668997 3401.62341451085 1.16063679977972 0.21491657760035 0.119316490747833 1 19.4291 20.0249 23.973 22.7122 GeneID:84687,Genbank:NM_032595.4,HGNC:HGNC:9298,MIM:603325 protein phosphatase 1 regulatory subunit 9B PPP2CA 5751.83430143702 6049.99984951153 5453.66875336251 0.901432874217812 -0.149708030449592 0.261304559343729 1 80.4228 79.7038 76.9096 69.2446 GeneID:5515,Genbank:NM_002715.3,HGNC:HGNC:9299,MIM:176915 protein phosphatase 2 catalytic subunit alpha GO:0000122,GO:0000159,GO:0000775,GO:0000922,GO:0001932,GO:0001933,GO:0003231,GO:0004722,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006470,GO:0007498,GO:0007507,GO:0008022,GO:0010288,GO:0010469,GO:0010719,GO:0014069,GO:0019899,GO:0019901,GO:0019903,GO:0019904,GO:0031698,GO:0031952,GO:0032403,GO:0032516,GO:0032869,GO:0035307,GO:0042176,GO:0042308,GO:0043005,GO:0043065,GO:0043195,GO:0043280,GO:0043422,GO:0044325,GO:0046872,GO:0046982,GO:0046983,GO:0048156,GO:0050811,GO:0051321,GO:0051721,GO:0070062,GO:0070208,GO:0071277,GO:0071333,GO:0071345,GO:0071361,GO:0071372,GO:0071383,GO:0071902,GO:1901020,GO:1904528,GO:1990405 negative regulation of transcription from RNA polymerase II promoter|protein phosphatase type 2A complex|chromosome, centromeric region|spindle pole|regulation of protein phosphorylation|negative regulation of protein phosphorylation|cardiac ventricle development|protein serine/threonine phosphatase activity|nucleus|cytoplasm|cytosol|plasma membrane|protein dephosphorylation|mesoderm development|heart development|protein C-terminus binding|response to lead ion|regulation of receptor activity|negative regulation of epithelial to mesenchymal transition|postsynaptic density|enzyme binding|protein kinase binding|protein phosphatase binding|protein domain specific binding|beta-2 adrenergic receptor binding|regulation of protein autophosphorylation|protein complex binding|positive regulation of phosphoprotein phosphatase activity|cellular response to insulin stimulus|positive regulation of protein dephosphorylation|regulation of protein catabolic process|negative regulation of protein import into nucleus|neuron projection|positive regulation of apoptotic process|terminal bouton|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein kinase B binding|ion channel binding|metal ion binding|protein heterodimerization activity|protein dimerization activity|tau protein binding|GABA receptor binding|meiotic cell cycle|protein phosphatase 2A binding|extracellular exosome|protein heterotrimerization|cellular response to calcium ion|cellular response to glucose stimulus|cellular response to cytokine stimulus|cellular response to ethanol|cellular response to follicle-stimulating hormone stimulus|cellular response to steroid hormone stimulus|positive regulation of protein serine/threonine kinase activity|negative regulation of calcium ion transmembrane transporter activity|positive regulation of microtubule binding|protein antigen binding hsa03015,hsa04071,hsa04114,hsa04136,hsa04140,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|Autophagy - other|Autophagy - animal|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease (American trypanosomiasis)|Hepatitis C|Human papillomavirus infection PPP2CB 3826.56661673709 3988.30912451025 3664.82410896394 0.918891689323096 -0.12203327525042 0.366519586806232 1 90.6103 90.7605 88.4652 80.428 GeneID:5516,Genbank:NM_001009552.1,HGNC:HGNC:9300,MIM:176916 protein phosphatase 2 catalytic subunit beta GO:0000159,GO:0000775,GO:0000922,GO:0004721,GO:0004722,GO:0005634,GO:0005737,GO:0006470,GO:0008022,GO:0008637,GO:0010288,GO:0010468,GO:0034976,GO:0042542,GO:0043161,GO:0046580,GO:0046677,GO:0046872,GO:0046982,GO:0070062,GO:1904528 protein phosphatase type 2A complex|chromosome, centromeric region|spindle pole|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|nucleus|cytoplasm|protein dephosphorylation|protein C-terminus binding|apoptotic mitochondrial changes|response to lead ion|regulation of gene expression|response to endoplasmic reticulum stress|response to hydrogen peroxide|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of Ras protein signal transduction|response to antibiotic|metal ion binding|protein heterodimerization activity|extracellular exosome|positive regulation of microtubule binding hsa03015,hsa04071,hsa04114,hsa04136,hsa04140,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|Autophagy - other|Autophagy - animal|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease (American trypanosomiasis)|Hepatitis C|Human papillomavirus infection PPP2R1A 8678.69282482846 8232.34455329714 9125.04109635978 1.10843770414166 0.148527690862529 0.267990498486726 1 96.9688 103.76 115.597 112.24 GeneID:5518,Genbank:NM_014225.5,HGNC:HGNC:9302,MIM:605983 protein phosphatase 2 scaffold subunit Aalpha GO:0000086,GO:0000159,GO:0000184,GO:0000188,GO:0000775,GO:0004722,GO:0005634,GO:0005739,GO:0005829,GO:0006275,GO:0006355,GO:0006461,GO:0006470,GO:0006672,GO:0006915,GO:0007059,GO:0007084,GO:0007143,GO:0008380,GO:0010033,GO:0010389,GO:0015630,GO:0016020,GO:0016328,GO:0019888,GO:0019932,GO:0030111,GO:0030155,GO:0030308,GO:0030425,GO:0040008,GO:0042532,GO:0045595,GO:0046982,GO:0051232,GO:0051306,GO:0051754,GO:0070062,GO:0070262,GO:0097711,GO:1903538,GO:1990405,GO:2001241 G2/M transition of mitotic cell cycle|protein phosphatase type 2A complex|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|inactivation of MAPK activity|chromosome, centromeric region|protein serine/threonine phosphatase activity|nucleus|mitochondrion|cytosol|regulation of DNA replication|regulation of transcription, DNA-templated|protein complex assembly|protein dephosphorylation|ceramide metabolic process|apoptotic process|chromosome segregation|mitotic nuclear envelope reassembly|female meiotic nuclear division|RNA splicing|response to organic substance|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|membrane|lateral plasma membrane|protein phosphatase regulator activity|second-messenger-mediated signaling|regulation of Wnt signaling pathway|regulation of cell adhesion|negative regulation of cell growth|dendrite|regulation of growth|negative regulation of tyrosine phosphorylation of STAT protein|regulation of cell differentiation|protein heterodimerization activity|meiotic spindle elongation|mitotic sister chromatid separation|meiotic sister chromatid cohesion, centromeric|extracellular exosome|peptidyl-serine dephosphorylation|ciliary basal body-plasma membrane docking|regulation of meiotic cell cycle process involved in oocyte maturation|protein antigen binding|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease (American trypanosomiasis)|Hepatitis C|Human papillomavirus infection PPP2R1B 719.510802532642 781.792709933226 657.228895132057 0.840668999315934 -0.250390221926322 0.158679041125301 1 2.76619 2.53503 2.63726 1.95007 GeneID:5519,Genbank:XM_024448599.1,HGNC:HGNC:9303,MIM:603113 protein phosphatase 2 scaffold subunit Abeta GO:0045121,GO:0060561,GO:0070062,GO:2001241 membrane raft|apoptotic process involved in morphogenesis|extracellular exosome|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04350,hsa04390,hsa04530,hsa04728,hsa04730,hsa05142,hsa05160,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|TGF-beta signaling pathway|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Long-term depression|Chagas disease (American trypanosomiasis)|Hepatitis C|Human papillomavirus infection PPP2R2A 1399.71979753089 1353.29203850122 1446.14755656055 1.06861454543261 0.0957415596312467 0.50504417444418 1 9.36098 9.60464 10.6028 9.8655 GeneID:5520,Genbank:NM_002717.3,HGNC:HGNC:9304,MIM:604941 protein phosphatase 2 regulatory subunit Balpha GO:0000159,GO:0000278,GO:0004722,GO:0005829,GO:0006470,GO:0019888,GO:0032403,GO:0032502,GO:0043278,GO:0048156,GO:0051721,GO:0070262 protein phosphatase type 2A complex|mitotic cell cycle|protein serine/threonine phosphatase activity|cytosol|protein dephosphorylation|protein phosphatase regulator activity|protein complex binding|developmental process|response to morphine|tau protein binding|protein phosphatase 2A binding|peptidyl-serine dephosphorylation hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04390,hsa04530,hsa04728,hsa05142,hsa05160,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Chagas disease (American trypanosomiasis)|Hepatitis C|Human papillomavirus infection PPP2R2B 752.858874347505 702.605090571691 803.11265812332 1.14304987097354 0.19288834934122 0.237697278979933 1 6.38972 6.40257 8.33879 6.57279 GeneID:5521,Genbank:NM_001271899.1,HGNC:HGNC:9305,MIM:604325 protein phosphatase 2 regulatory subunit Bbeta GO:0000159,GO:0000278,GO:0005739,GO:0005741,GO:0005829,GO:0005856,GO:0006915,GO:0019888,GO:0032502,GO:0070262 protein phosphatase type 2A complex|mitotic cell cycle|mitochondrion|mitochondrial outer membrane|cytosol|cytoskeleton|apoptotic process|protein phosphatase regulator activity|developmental process|peptidyl-serine dephosphorylation hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04390,hsa04530,hsa04728,hsa05142,hsa05160,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Chagas disease (American trypanosomiasis)|Hepatitis C|Human papillomavirus infection PPP2R2C 3.31322868058701 3.71865746181119 2.90779989936283 0.781948842888738 -0.35485386910013 0.957126709579746 1 0.0415007 0.00625609 0.00652284 0.0121608 GeneID:5522,Genbank:NM_001206994.1,HGNC:HGNC:9306,MIM:605997 protein phosphatase 2 regulatory subunit Bgamma GO:0000159,GO:0019888 protein phosphatase type 2A complex|protein phosphatase regulator activity hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04390,hsa04530,hsa04728,hsa05142,hsa05160,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Chagas disease (American trypanosomiasis)|Hepatitis C|Human papillomavirus infection PPP2R2D 1269.89832540414 1208.07127539099 1331.72537541729 1.10235662625641 0.140591029443104 0.34572063597994 1 4.12848 4.37822 4.95361 4.8646 GeneID:55844,Genbank:NM_001291310.1,HGNC:HGNC:23732,MIM:613992 protein phosphatase 2 regulatory subunit Bdelta GO:0000159,GO:0000278,GO:0005829,GO:0010458,GO:0019888,GO:0032502,GO:0051301,GO:0070262 protein phosphatase type 2A complex|mitotic cell cycle|cytosol|exit from mitosis|protein phosphatase regulator activity|developmental process|cell division|peptidyl-serine dephosphorylation hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04390,hsa04530,hsa04728,hsa05142,hsa05160,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Hippo signaling pathway|Tight junction|Dopaminergic synapse|Chagas disease (American trypanosomiasis)|Hepatitis C|Human papillomavirus infection PPP2R3A 167.008976784114 156.156221432456 177.861732135773 1.13899869313056 0.187766091721053 0.539800586338134 1 0.674109 0.454824 0.693557 0.612982 GeneID:5523,Genbank:XM_017006787.2,HGNC:HGNC:9307,MIM:604944 protein phosphatase 2 regulatory subunit B''alpha GO:0000159,GO:0001754,GO:0005509,GO:0006470,GO:0007525,GO:0019888,GO:0030674,GO:0045732,GO:0061053,GO:0090090,GO:0090244,GO:0090249,GO:0090263 protein phosphatase type 2A complex|eye photoreceptor cell differentiation|calcium ion binding|protein dephosphorylation|somatic muscle development|protein phosphatase regulator activity|protein binding, bridging|positive regulation of protein catabolic process|somite development|negative regulation of canonical Wnt signaling pathway|Wnt signaling pathway involved in somitogenesis|regulation of cell motility involved in somitogenic axis elongation|positive regulation of canonical Wnt signaling pathway hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R3B 32.308877048263 29.250396638279 35.3673574582469 1.2091240298589 0.273962241348409 0.860909871287287 1 0.0685585 0.652392 0.0785512 0.29434 GeneID:28227,Genbank:NM_013239.4,HGNC:HGNC:13417,MIM:300339 protein phosphatase 2 regulatory subunit B''beta GO:0000159,GO:0004721,GO:0004722,GO:0005509,GO:0005634,GO:0005654,GO:0006470,GO:0007050,GO:0019888 protein phosphatase type 2A complex|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|calcium ion binding|nucleus|nucleoplasm|protein dephosphorylation|cell cycle arrest|protein phosphatase regulator activity hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R3C 256.491310714029 275.529695754495 237.452925673563 0.861805204057354 -0.214566284620699 0.360876508382434 1 3.31009 2.6904 2.58664 2.62269 GeneID:55012,Genbank:NM_001305156.1,HGNC:HGNC:17485,MIM:615902 protein phosphatase 2 regulatory subunit B''gamma GO:0000226,GO:0001782,GO:0002759,GO:0005634,GO:0005794,GO:0005813,GO:0005819,GO:0005829,GO:0030865,GO:0032147,GO:0043029,GO:0045579,GO:0046872,GO:0048536,GO:0051900 microtubule cytoskeleton organization|B cell homeostasis|regulation of antimicrobial humoral response|nucleus|Golgi apparatus|centrosome|spindle|cytosol|cortical cytoskeleton organization|activation of protein kinase activity|T cell homeostasis|positive regulation of B cell differentiation|metal ion binding|spleen development|regulation of mitochondrial depolarization hsa03015,hsa04071,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5A 548.406296264424 515.727241294229 581.085351234619 1.12672999350659 0.172141833434611 0.297077035806315 1 6.66761 5.97826 7.42222 6.5759 GeneID:5525,Genbank:NM_006243.3,HGNC:HGNC:9309,MIM:601643 protein phosphatase 2 regulatory subunit B'alpha GO:0000159,GO:0000775,GO:0004721,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0006470,GO:0007165,GO:0019888,GO:0019900,GO:0030018,GO:0031430,GO:0035307,GO:0090219,GO:1903077 protein phosphatase type 2A complex|chromosome, centromeric region|phosphoprotein phosphatase activity|nucleus|cytoplasm|centrosome|cytosol|protein dephosphorylation|signal transduction|protein phosphatase regulator activity|kinase binding|Z disc|M band|positive regulation of protein dephosphorylation|negative regulation of lipid kinase activity|negative regulation of protein localization to plasma membrane hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5B 328.173237524539 314.687381636399 341.659093412679 1.08570954334433 0.118638194832845 0.551190834395203 1 4.14 4.13948 4.59303 4.5165 GeneID:5526,Genbank:XM_011545133.1,HGNC:HGNC:9310,MIM:601644 protein phosphatase 2 regulatory subunit B'beta GO:0000159,GO:0005737,GO:0005829,GO:0010469,GO:0010976,GO:0014066,GO:0019888,GO:0031334,GO:0031952,GO:0036498,GO:0045944,GO:0050730,GO:0051091,GO:0051388,GO:0051898,GO:0070317,GO:0071158,GO:0071363 protein phosphatase type 2A complex|cytoplasm|cytosol|regulation of receptor activity|positive regulation of neuron projection development|regulation of phosphatidylinositol 3-kinase signaling|protein phosphatase regulator activity|positive regulation of protein complex assembly|regulation of protein autophosphorylation|IRE1-mediated unfolded protein response|positive regulation of transcription from RNA polymerase II promoter|regulation of peptidyl-tyrosine phosphorylation|positive regulation of DNA binding transcription factor activity|positive regulation of neurotrophin TRK receptor signaling pathway|negative regulation of protein kinase B signaling|negative regulation of G0 to G1 transition|positive regulation of cell cycle arrest|cellular response to growth factor stimulus hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5C 1355.25089386983 1440.21392208875 1270.28786565092 0.882013321888056 -0.181127648541427 0.265266326298963 1 9.30233 8.12903 8.51711 7.0433 GeneID:5527,Genbank:XM_005267827.1,HGNC:HGNC:9311,MIM:601645 protein phosphatase 2 regulatory subunit B'gamma GO:0000159,GO:0000775,GO:0005634,GO:0005654,GO:0005794,GO:0005829,GO:0006977,GO:0007165,GO:0008285,GO:0014066,GO:0019888,GO:0042771,GO:0043161,GO:0051898 protein phosphatase type 2A complex|chromosome, centromeric region|nucleus|nucleoplasm|Golgi apparatus|cytosol|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|signal transduction|negative regulation of cell proliferation|regulation of phosphatidylinositol 3-kinase signaling|protein phosphatase regulator activity|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of protein kinase B signaling hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5D 2760.92407175549 2573.98070882927 2947.86743468171 1.1452562268901 0.195670406976455 0.154739732797908 1 25.415 25.3101 29.004 30.108 GeneID:5528,Genbank:NM_001270476.1,HGNC:HGNC:9312,MIM:601646 protein phosphatase 2 regulatory subunit B'delta GO:0000159,GO:0004721,GO:0004722,GO:0005634,GO:0005654,GO:0005829,GO:0006470,GO:0007165,GO:0007399,GO:0019888,GO:0035307 protein phosphatase type 2A complex|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|nucleus|nucleoplasm|cytosol|protein dephosphorylation|signal transduction|nervous system development|protein phosphatase regulator activity|positive regulation of protein dephosphorylation hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP2R5E 594.55308952039 583.28843417859 605.817744862191 1.038624648396 0.0546743686441804 0.71926249779098 1 2.60094 2.35032 2.70245 2.38615 GeneID:5529,Genbank:NM_001282179.2,HGNC:HGNC:9313,MIM:601647 protein phosphatase 2 regulatory subunit B'epsilon GO:0000159,GO:0005737,GO:0005829,GO:0007165,GO:0019888 protein phosphatase type 2A complex|cytoplasm|cytosol|signal transduction|protein phosphatase regulator activity hsa03015,hsa04071,hsa04114,hsa04151,hsa04152,hsa04261,hsa04728,hsa05165 mRNA surveillance pathway|Sphingolipid signaling pathway|Oocyte meiosis|PI3K-Akt signaling pathway|AMPK signaling pathway|Adrenergic signaling in cardiomyocytes|Dopaminergic synapse|Human papillomavirus infection PPP3CA 540.347309029886 598.894283802071 481.800334257701 0.804483107100303 -0.313865967982764 0.174455019399972 1 5.22811 5.2196 5.08886 3.42824 GeneID:5530,Genbank:NM_001130692.1,HGNC:HGNC:9314,MIM:114105 protein phosphatase 3 catalytic subunit alpha hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04728,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170 MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Dopaminergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection PPP3CB 1606.72542231987 1645.64684105569 1567.80400358406 0.95269772618912 -0.0699095492749244 0.646471425552127 1 13.4893 12.7294 13.2482 12.0703 GeneID:5532,Genbank:NM_021132.3,HGNC:HGNC:9315,MIM:114106 protein phosphatase 3 catalytic subunit beta GO:0001915,GO:0001946,GO:0004722,GO:0004723,GO:0005509,GO:0005516,GO:0005829,GO:0005886,GO:0005955,GO:0006468,GO:0006470,GO:0007507,GO:0008144,GO:0010468,GO:0017156,GO:0019899,GO:0030018,GO:0030217,GO:0030315,GO:0030346,GO:0031987,GO:0033173,GO:0033192,GO:0034097,GO:0035176,GO:0035690,GO:0035774,GO:0043029,GO:0045944,GO:0046983,GO:0050796 negative regulation of T cell mediated cytotoxicity|lymphangiogenesis|protein serine/threonine phosphatase activity|calcium-dependent protein serine/threonine phosphatase activity|calcium ion binding|calmodulin binding|cytosol|plasma membrane|calcineurin complex|protein phosphorylation|protein dephosphorylation|heart development|drug binding|regulation of gene expression|calcium ion regulated exocytosis|enzyme binding|Z disc|T cell differentiation|T-tubule|protein phosphatase 2B binding|locomotion involved in locomotory behavior|calcineurin-NFAT signaling cascade|calmodulin-dependent protein phosphatase activity|response to cytokine|social behavior|cellular response to drug|positive regulation of insulin secretion involved in cellular response to glucose stimulus|T cell homeostasis|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|regulation of insulin secretion hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04728,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170 MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Dopaminergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection PPP3CC 657.025170139871 682.609232641663 631.441107638078 0.925040385396537 -0.112411742729279 0.486774276518888 1 6.77574 7.63302 6.69431 6.83114 GeneID:5533,Genbank:NM_001243974.1,HGNC:HGNC:9316,MIM:114107 protein phosphatase 3 catalytic subunit gamma GO:0004721,GO:0005516,GO:0005739,GO:0005829,GO:0007420,GO:0046872,GO:0070062,GO:1900740 phosphoprotein phosphatase activity|calmodulin binding|mitochondrion|cytosol|brain development|metal ion binding|extracellular exosome|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04728,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170 MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Dopaminergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection PPP3R1 1176.78402328412 1244.66090040182 1108.90714616642 0.890931132976401 -0.166614175994549 0.275554538098487 1 20.4999 19.4507 19.4602 15.9594 GeneID:5534,Genbank:NM_000945.3,HGNC:HGNC:9317,MIM:601302 protein phosphatase 3 regulatory subunit B, alpha GO:0001569,GO:0001837,GO:0004721,GO:0005509,GO:0005829,GO:0005955,GO:0006470,GO:0007507,GO:0014044,GO:0016018,GO:0019899,GO:0019904,GO:0022011,GO:0033173,GO:0034504,GO:0042383,GO:0045944,GO:0051531,GO:0060487 branching involved in blood vessel morphogenesis|epithelial to mesenchymal transition|phosphoprotein phosphatase activity|calcium ion binding|cytosol|calcineurin complex|protein dephosphorylation|heart development|Schwann cell development|cyclosporin A binding|enzyme binding|protein domain specific binding|myelination in peripheral nervous system|calcineurin-NFAT signaling cascade|protein localization to nucleus|sarcolemma|positive regulation of transcription from RNA polymerase II promoter|NFAT protein import into nucleus|lung epithelial cell differentiation hsa04010,hsa04020,hsa04022,hsa04114,hsa04218,hsa04310,hsa04360,hsa04370,hsa04380,hsa04625,hsa04650,hsa04658,hsa04659,hsa04660,hsa04662,hsa04720,hsa04724,hsa04921,hsa04922,hsa04924,hsa05010,hsa05014,hsa05031,hsa05152,hsa05163,hsa05166,hsa05167,hsa05170 MAPK signaling pathway|Calcium signaling pathway|cGMP-PKG signaling pathway|Oocyte meiosis|Cellular senescence|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|Long-term potentiation|Glutamatergic synapse|Oxytocin signaling pathway|Glucagon signaling pathway|Renin secretion|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Amphetamine addiction|Tuberculosis|Human cytomegalovirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection PPP4C 2216.32582548207 2202.99600190013 2229.655649064 1.01210154132866 0.0173540388686168 0.926318097770211 1 43.2863 46.3546 45.3298 48.4454 GeneID:5531,Genbank:NM_001303503.1,HGNC:HGNC:9319,MIM:602035 protein phosphatase 4 catalytic subunit GO:0004704,GO:0004722,GO:0005634,GO:0005654,GO:0005815,GO:0005829,GO:0005886,GO:0010569,GO:0030289,GO:0046872 NF-kappaB-inducing kinase activity|protein serine/threonine phosphatase activity|nucleus|nucleoplasm|microtubule organizing center|cytosol|plasma membrane|regulation of double-strand break repair via homologous recombination|protein phosphatase 4 complex|metal ion binding hsa04922 Glucagon signaling pathway PPP4R1 3848.40927849935 3763.92915100295 3932.88940599575 1.04488932926588 0.0633501455841452 0.641855712314717 1 31.4067 32.6488 35.7253 31.615 GeneID:9989,Genbank:NM_005134.3,HGNC:HGNC:9320,MIM:604908 protein phosphatase 4 regulatory subunit 1 GO:0006468,GO:0006470,GO:0007165,GO:0019888,GO:0030289 protein phosphorylation|protein dephosphorylation|signal transduction|protein phosphatase regulator activity|protein phosphatase 4 complex PPP4R2 1059.14173989797 1142.62222159192 975.661258204023 0.853879120996543 -0.227896245044034 0.201145591498373 1 8.40726 7.86457 7.85402 5.93893 GeneID:151987,Genbank:NM_001318026.1,HGNC:HGNC:18296,MIM:613822 protein phosphatase 4 regulatory subunit 2 GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0006397,GO:0006464,GO:0008380,GO:0010569,GO:0019888,GO:0030289,GO:0030674 nucleus|nucleoplasm|cytoplasm|centrosome|mRNA processing|cellular protein modification process|RNA splicing|regulation of double-strand break repair via homologous recombination|protein phosphatase regulator activity|protein phosphatase 4 complex|protein binding, bridging PPP4R3A 910.980803325686 972.829227798062 849.13237885331 0.872848342329587 -0.196197087969455 0.366945232567052 1 8.20198 6.9581 7.40158 5.83089 GeneID:55671,Genbank:NM_001284281.1,HGNC:HGNC:20219,MIM:610351 protein phosphatase 4 regulatory subunit 3A GO:0005634,GO:0005654,GO:0005737,GO:0005815,GO:0006470,GO:0030289,GO:0045722 nucleus|nucleoplasm|cytoplasm|microtubule organizing center|protein dephosphorylation|protein phosphatase 4 complex|positive regulation of gluconeogenesis hsa04922 Glucagon signaling pathway PPP4R3B 567.792108899042 626.201978141027 509.382239657058 0.813447190264768 -0.297879407030352 0.224597129921865 1 3.74915 3.04832 3.12865 2.61039 GeneID:57223,Genbank:XM_024453014.1,HGNC:HGNC:29267,MIM:610352 protein phosphatase 4 regulatory subunit 3B GO:0005654,GO:0005737,GO:0005813,GO:0006470,GO:0016607,GO:0019216,GO:0030289,GO:0045722 nucleoplasm|cytoplasm|centrosome|protein dephosphorylation|nuclear speck|regulation of lipid metabolic process|protein phosphatase 4 complex|positive regulation of gluconeogenesis hsa04922 Glucagon signaling pathway PPP4R4 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0156116 0 GeneID:57718,Genbank:NM_001348144.1,HGNC:HGNC:23788,MIM:616790 protein phosphatase 4 regulatory subunit 4 GO:0005737,GO:0005829,GO:0008287,GO:0019888,GO:0032515,GO:0080163 cytoplasm|cytosol|protein serine/threonine phosphatase complex|protein phosphatase regulator activity|negative regulation of phosphoprotein phosphatase activity|regulation of protein serine/threonine phosphatase activity PPP5C 3696.61897140778 3783.81340707681 3609.42453573876 0.953911873399492 -0.0680721050530235 0.594724517813962 1 45.5674 47.9775 45.7881 46.0927 GeneID:5536,Genbank:NM_006247.3,HGNC:HGNC:9322,MIM:600658 protein phosphatase 5 catalytic subunit GO:0000165,GO:0000278,GO:0001933,GO:0001965,GO:0003723,GO:0004721,GO:0004722,GO:0004871,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006281,GO:0006351,GO:0006470,GO:0008017,GO:0008289,GO:0010288,GO:0016576,GO:0035970,GO:0042802,GO:0043123,GO:0043204,GO:0043231,GO:0043234,GO:0043278,GO:0043531,GO:0046872,GO:0051291,GO:0051879,GO:0070262,GO:0070301,GO:0071276,GO:1901215,GO:1990635,GO:2000324 MAPK cascade|mitotic cell cycle|negative regulation of protein phosphorylation|G-protein alpha-subunit binding|RNA binding|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|signal transducer activity|ATP binding|nucleus|nucleoplasm|cytosol|plasma membrane|DNA repair|transcription, DNA-templated|protein dephosphorylation|microtubule binding|lipid binding|response to lead ion|histone dephosphorylation|peptidyl-threonine dephosphorylation|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|perikaryon|intracellular membrane-bounded organelle|protein complex|response to morphine|ADP binding|metal ion binding|protein heterooligomerization|Hsp90 protein binding|peptidyl-serine dephosphorylation|cellular response to hydrogen peroxide|cellular response to cadmium ion|negative regulation of neuron death|proximal dendrite|positive regulation of glucocorticoid receptor signaling pathway hsa04010 MAPK signaling pathway PPP5D1 17.2764628567555 14.682524748505 19.870400965006 1.35333679359398 0.436520915429071 0.515756556409595 1 0.187062 0.0575096 0.201178 0.143321 GeneID:100506012,Genbank:NM_001205281.1,HGNC:HGNC:44209 PPP5 tetratricopeptide repeat domain containing 1 hsa04010 MAPK signaling pathway PPP6C 1270.45077579875 1358.39364927379 1182.50790232371 0.870519310036446 -0.200051794501122 0.184392867964283 1 13.7222 12.9453 11.8902 11.1711 GeneID:5537,Genbank:NM_001123369.1,HGNC:HGNC:9323,MIM:612725 protein phosphatase 6 catalytic subunit GO:0000082,GO:0000139,GO:0004722,GO:0005739,GO:0005829,GO:0006470,GO:0045087,GO:0046872,GO:0048208 G1/S transition of mitotic cell cycle|Golgi membrane|protein serine/threonine phosphatase activity|mitochondrion|cytosol|protein dephosphorylation|innate immune response|metal ion binding|COPII vesicle coating PPP6R1 4656.68569067898 4404.14637105117 4909.22501030679 1.11468252794129 0.156632875542833 0.25091171264048 1 37.5863 38.6581 43.8597 42.324 GeneID:22870,Genbank:NM_014931.3,HGNC:HGNC:29195,MIM:610875 protein phosphatase 6 regulatory subunit 1 GO:0000139,GO:0005829,GO:0017048,GO:0019903,GO:0043666,GO:0048208 Golgi membrane|cytosol|Rho GTPase binding|protein phosphatase binding|regulation of phosphoprotein phosphatase activity|COPII vesicle coating PPP6R2 1547.68637106341 1388.55857913279 1706.81416299403 1.22919852906746 0.297717945629297 0.0401201235652383 0.758464027333929 7.39893 7.90019 9.93549 9.78937 GeneID:9701,Genbank:NM_001351643.1,HGNC:HGNC:19253,MIM:610877 protein phosphatase 6 regulatory subunit 2 GO:0005829,GO:0043231 cytosol|intracellular membrane-bounded organelle PPP6R3 1333.80473382394 1501.98151904473 1165.62794860314 0.776060113805185 -0.365759686637797 0.0158774607968904 0.525399611824373 5.15961 4.52037 4.21177 3.28275 GeneID:55291,Genbank:NM_001352362.1,HGNC:HGNC:1173,MIM:610879 protein phosphatase 6 regulatory subunit 3 GO:0000139,GO:0005654,GO:0005829,GO:0005886,GO:0019903,GO:0043666,GO:0048208 Golgi membrane|nucleoplasm|cytosol|plasma membrane|protein phosphatase binding|regulation of phosphoprotein phosphatase activity|COPII vesicle coating PPRC1 1593.46693726947 1649.12841814664 1537.8054563923 0.9324958805334 -0.10083074286765 0.469634274021086 1 8.50539 9.09887 9.20405 7.83401 GeneID:23082,Genbank:XM_024447914.1,HGNC:HGNC:30025,MIM:617462 peroxisome proliferator-activated receptor gamma, coactivator-related 1 GO:0001104,GO:0003723,GO:0005634,GO:0005654,GO:0006351,GO:0007005,GO:0008134,GO:0030374,GO:0045944,GO:0051091 RNA polymerase II transcription cofactor activity|RNA binding|nucleus|nucleoplasm|transcription, DNA-templated|mitochondrion organization|transcription factor binding|ligand-dependent nuclear receptor transcription coactivator activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of DNA binding transcription factor activity PPT1 5941.80180435524 5117.47214653356 6766.13146217691 1.32216283126428 0.402899863223312 0.00234845291594797 0.176586018318416 78.3235 82.3222 113.752 100.56 GeneID:5538,Genbank:XM_005271008.2,HGNC:HGNC:9325,MIM:600722 palmitoyl-protein thioesterase 1 hsa00062,hsa04142 Fatty acid elongation|Lysosome PPT2 1115.34664883944 1187.26776244558 1043.42553523331 0.878846009500018 -0.186317694925933 0.211308072315434 1 22.6708 22.9603 21.5731 19.4617 GeneID:9374,Genbank:NM_138717.2,HGNC:HGNC:9326,MIM:603298 palmitoyl-protein thioesterase 2 GO:0005764,GO:0008474,GO:0016790,GO:0043202,GO:0043231,GO:0046949,GO:0070062,GO:0098599 lysosome|palmitoyl-(protein) hydrolase activity|thiolester hydrolase activity|lysosomal lumen|intracellular membrane-bounded organelle|fatty-acyl-CoA biosynthetic process|extracellular exosome|palmitoyl hydrolase activity hsa00062,hsa04142 Fatty acid elongation|Lysosome PPTC7 783.329435600936 886.156267238219 680.502603963654 0.767926187651416 -0.380960447778031 0.0719536835123948 0.928200388965456 8.88567 7.82393 7.68023 5.49549 GeneID:160760,Genbank:XM_024448869.1,HGNC:HGNC:30695,MIM:609668 PTC7 protein phosphatase homolog GO:0004721,GO:0005739,GO:0046872 phosphoprotein phosphatase activity|mitochondrion|metal ion binding PPWD1 202.323267585648 228.23391813891 176.412617032385 0.772946538669223 -0.371559462191375 0.128838071521294 1 2.90115 2.61375 2.3658 2.09058 GeneID:23398,Genbank:NM_015342.3,HGNC:HGNC:28954 peptidylprolyl isomerase domain and WD repeat containing 1 GO:0000398,GO:0003755,GO:0005654,GO:0016604,GO:0071013 mRNA splicing, via spliceosome|peptidyl-prolyl cis-trans isomerase activity|nucleoplasm|nuclear body|catalytic step 2 spliceosome PPY 0.729234031512454 0.490071401957362 0.968396661067546 1.97603177251261 0.982606144127986 1 1 0 0.069462 0 0 GeneID:5539,Genbank:XM_011524978.3,HGNC:HGNC:9327,MIM:167780 pancreatic polypeptide GO:0001664,GO:0005102,GO:0005179,GO:0005184,GO:0005576,GO:0005615,GO:0005737,GO:0007186,GO:0007218,GO:0007267,GO:0007586,GO:0007631,GO:0009306,GO:0032098 G-protein coupled receptor binding|receptor binding|hormone activity|neuropeptide hormone activity|extracellular region|extracellular space|cytoplasm|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|cell-cell signaling|digestion|feeding behavior|protein secretion|regulation of appetite hsa04080 Neuroactive ligand-receptor interaction PQBP1 991.922805227759 1045.66858724693 938.177023208587 0.897203028426673 -0.156493604769944 0.301295729676492 1 17.8561 18.5761 15.9459 17.6463 GeneID:10084,Genbank:XM_017029207.1,HGNC:HGNC:9330,MIM:300463 polyglutamine binding protein 1 GO:0000380,GO:0000398,GO:0002218,GO:0002230,GO:0003677,GO:0003690,GO:0003713,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0010494,GO:0016607,GO:0031175,GO:0032481,GO:0043021,GO:0043484,GO:0045087,GO:0048814,GO:0051607,GO:0071360,GO:0071598 alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|activation of innate immune response|positive regulation of defense response to virus by host|DNA binding|double-stranded DNA binding|transcription coactivator activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|cytoplasmic stress granule|nuclear speck|neuron projection development|positive regulation of type I interferon production|ribonucleoprotein complex binding|regulation of RNA splicing|innate immune response|regulation of dendrite morphogenesis|defense response to virus|cellular response to exogenous dsRNA|neuronal ribonucleoprotein granule hsa03040 Spliceosome PQLC1 312.956303020819 313.813100036962 312.099506004677 0.994539443917149 -0.00789950470798287 0.965099765331802 1 2.81984 3.08315 2.91287 2.91366 GeneID:80148,Genbank:XM_005266770.2,HGNC:HGNC:26188 PQ loop repeat containing 1 GO:0016021 integral component of membrane PQLC2 731.647309525661 703.884216679678 759.410402371645 1.07888539674024 0.109541624477823 0.518866300066785 1 3.50959 3.81995 4.19766 3.94207 GeneID:54896,Genbank:NM_001040125.1,HGNC:HGNC:26001,MIM:614760 PQ loop repeat containing 2 GO:0005765,GO:0015174,GO:0015181,GO:0015189,GO:0015809,GO:0015819,GO:0031301,GO:0043231,GO:0055085,GO:0080144 lysosomal membrane|basic amino acid transmembrane transporter activity|arginine transmembrane transporter activity|L-lysine transmembrane transporter activity|arginine transport|lysine transport|integral component of organelle membrane|intracellular membrane-bounded organelle|transmembrane transport|amino acid homeostasis PQLC2L 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0182046 GeneID:152078,Genbank:NM_001130002.2,HGNC:HGNC:25146 PQ loop repeat containing 2 like PQLC3 153.894924920011 156.589474905475 151.200374934547 0.965584532586361 -0.0505255287153866 0.841889621339393 1 1.11663 1.29998 1.1622 1.07706 GeneID:130814,Genbank:NM_001282712.1,HGNC:HGNC:28503 PQ loop repeat containing 3 GO:0006488,GO:0016021 dolichol-linked oligosaccharide biosynthetic process|integral component of membrane PRAC2 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0.0438287 0 GeneID:360205,Genbank:XM_011524747.2,HGNC:HGNC:30143,MIM:610787 PRAC2 small nuclear protein GO:0005634 nucleus PRADC1 449.492935665254 394.03971413306 504.946157197448 1.28146006376133 0.357788518261754 0.0827005223404329 0.963076417285947 11.8671 14.1145 16.6942 18.5086 GeneID:84279,Genbank:NM_032319.2,HGNC:HGNC:16047 protease associated domain containing 1 GO:0005576,GO:0070062 extracellular region|extracellular exosome PRAF2 847.198354061968 743.088911835412 951.307796288523 1.28020722841741 0.356377359609455 0.0244249614258692 0.624239560191094 19.0713 20.2352 25.3253 25.3138 GeneID:11230,Genbank:NM_007213.2,HGNC:HGNC:28911,MIM:300840 PRA1 domain family member 2 GO:0010008,GO:0015031,GO:0015813,GO:0016021 endosome membrane|protein transport|L-glutamate transport|integral component of membrane PRAG1 307.601695647774 293.893677346089 321.309713949459 1.09328556112858 0.128670275498433 0.538763291525227 1 2.05739 2.38183 2.53427 2.41311 GeneID:157285,Genbank:XM_005272369.5,HGNC:HGNC:25438,MIM:617344 PEAK1 related, kinase-activating pseudokinase 1 GO:0004672,GO:0004715,GO:0005524 protein kinase activity|non-membrane spanning protein tyrosine kinase activity|ATP binding PRAM1 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.0505535 0 GeneID:84106,Genbank:XM_005272502.2,HGNC:HGNC:30091,MIM:606466 PML-RARA regulated adaptor molecule 1 GO:0007165,GO:0007229,GO:0008289,GO:0019901,GO:0043234,GO:0043313 signal transduction|integrin-mediated signaling pathway|lipid binding|protein kinase binding|protein complex|regulation of neutrophil degranulation PRAME 1.21136579838783 0 2.42273159677566 Inf Inf 0.33960385030001 1 0 0 0.0241006 0.0337299 GeneID:23532,Genbank:NM_206954.2,HGNC:HGNC:9336,MIM:606021 preferentially expressed antigen in melanoma GO:0005634,GO:0005886,GO:0006351,GO:0006915,GO:0008284,GO:0030154,GO:0040008,GO:0042974,GO:0043066,GO:0045596,GO:0045892,GO:0048387 nucleus|plasma membrane|transcription, DNA-templated|apoptotic process|positive regulation of cell proliferation|cell differentiation|regulation of growth|retinoic acid receptor binding|negative regulation of apoptotic process|negative regulation of cell differentiation|negative regulation of transcription, DNA-templated|negative regulation of retinoic acid receptor signaling pathway PRC1 9434.67290804583 9254.7450325769 9614.60078351476 1.03888337816668 0.0550337108505566 0.661670334144062 1 87.9344 84.5355 93.1523 87.1353 GeneID:9055,Genbank:NM_001267580.1,HGNC:HGNC:9341,MIM:603484 protein regulator of cytokinesis 1 GO:0000022,GO:0000910,GO:0000922,GO:0001578,GO:0005634,GO:0005819,GO:0005829,GO:0005876,GO:0008017,GO:0008284,GO:0019894,GO:0019901,GO:0030496,GO:0042802,GO:0070938 mitotic spindle elongation|cytokinesis|spindle pole|microtubule bundle formation|nucleus|spindle|cytosol|spindle microtubule|microtubule binding|positive regulation of cell proliferation|kinesin binding|protein kinase binding|midbody|identical protein binding|contractile ring PRCC 1975.56488954297 1900.22422138987 2050.90555769607 1.07929660858443 0.110091395807656 0.457587850233585 1 24.6116 28.4381 28.858 29.1453 GeneID:5546,Genbank:NM_005973.4,HGNC:HGNC:9343,MIM:179755 papillary renal cell carcinoma (translocation-associated) hsa05202,hsa05211 Transcriptional misregulation in cancer|Renal cell carcinoma PRCD 1.21430233409962 0.490071401957362 1.93853326624189 3.95561393400904 1.98390162663545 0.683537482026705 1 0 0.00566228 0.0118697 0.00554837 GeneID:768206,Genbank:XM_017025013.1,HGNC:HGNC:32528,MIM:610598 photoreceptor disc component GO:0001750,GO:0005576,GO:0005737,GO:0005783,GO:0005794,GO:0007601,GO:0050896 photoreceptor outer segment|extracellular region|cytoplasm|endoplasmic reticulum|Golgi apparatus|visual perception|response to stimulus PRCP 2166.56227248518 2104.85624299397 2228.2683019764 1.05863206068976 0.0822012517906155 0.557882636879774 1 21.6651 23.2866 24.2424 24.3619 GeneID:5547,Genbank:NM_001319214.1,HGNC:HGNC:9344,MIM:176785 prolylcarboxypeptidase GO:0002155,GO:0002353,GO:0003085,GO:0004185,GO:0005886,GO:0006508,GO:0007597,GO:0008239,GO:0035577,GO:0042593,GO:0043312,GO:0043535,GO:0045178,GO:0060055,GO:0070062,GO:0097009,GO:0101003,GO:2000377 regulation of thyroid hormone mediated signaling pathway|plasma kallikrein-kinin cascade|negative regulation of systemic arterial blood pressure|serine-type carboxypeptidase activity|plasma membrane|proteolysis|blood coagulation, intrinsic pathway|dipeptidyl-peptidase activity|azurophil granule membrane|glucose homeostasis|neutrophil degranulation|regulation of blood vessel endothelial cell migration|basal part of cell|angiogenesis involved in wound healing|extracellular exosome|energy homeostasis|ficolin-1-rich granule membrane|regulation of reactive oxygen species metabolic process hsa04614,hsa04974 Renin-angiotensin system|Protein digestion and absorption PRDM1 324.702415689969 371.697326396014 277.707504983924 0.747133447734432 -0.420562144791214 0.0334841454429844 0.722752120505173 1.58442 1.447 1.18688 1.0431 GeneID:639,Genbank:XM_017011187.1,HGNC:HGNC:9346,MIM:603423 PR/SET domain 1 PRDM10 219.803667480946 223.400847704237 216.206487257655 0.967796181077579 -0.0472248485340976 0.931513665574041 1 0.876715 0.784506 1.05991 0.542617 GeneID:56980,Genbank:NM_199437.1,HGNC:HGNC:13995 PR/SET domain 10 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008168,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|methyltransferase activity|metal ion binding PRDM11 139.106491819991 145.413885209825 132.799098430157 0.91324909061149 -0.130919682895686 0.63136359590628 1 0.399287 0.332504 0.399482 0.289255 GeneID:56981,Genbank:NM_001359633.1,HGNC:HGNC:13996,MIM:616347 PR/SET domain 11 GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0008168 nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|methyltransferase activity PRDM12 2.97420699389684 3.52655236307142 2.42186162472226 0.686750507402919 -0.542142023656264 0.840373292163848 1 0.0231374 0.0987108 0.0212435 0.0792362 GeneID:59335,Genbank:NM_021619.2,HGNC:HGNC:13997,MIM:616458 PR/SET domain 12 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008168,GO:0019233,GO:0031175,GO:0046872,GO:0050965,GO:0051574,GO:1900111,GO:1990226 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|methyltransferase activity|sensory perception of pain|neuron projection development|metal ion binding|detection of temperature stimulus involved in sensory perception of pain|positive regulation of histone H3-K9 methylation|positive regulation of histone H3-K9 dimethylation|histone methyltransferase binding PRDM13 0.969701619147642 0 1.93940323829528 Inf Inf 0.451735954600221 1 0 0 0.0538713 0.0167576 GeneID:59336,Genbank:NM_021620.3,HGNC:HGNC:13998,MIM:616741 PR/SET domain 13 GO:0000122,GO:0003677,GO:0003682,GO:0005634,GO:0006351,GO:0022008,GO:0042054,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|chromatin binding|nucleus|transcription, DNA-templated|neurogenesis|histone methyltransferase activity|metal ion binding PRDM15 247.159881286178 246.174454912593 248.145307659762 1.00800591900516 0.0115041103599722 0.957222514956504 1 0.761747 0.668134 0.802576 0.696581 GeneID:63977,Genbank:NM_001040424.2,HGNC:HGNC:13999,MIM:617692 PR/SET domain 15 GO:0003677,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0008168,GO:0016604,GO:0046872 DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|methyltransferase activity|nuclear body|metal ion binding PRDM16 162.045748598367 148.16220852283 175.929288673905 1.18741000439931 0.247818173547222 0.318890467067901 1 0.570718 0.576599 0.772176 0.647234 GeneID:63976,Genbank:XM_005244772.5,HGNC:HGNC:14000,MIM:605557 PR/SET domain 16 hsa04714 Thermogenesis PRDM2 587.357506902209 605.265212027517 569.449801776901 0.940826914319689 -0.087998762816673 0.609000614479766 1 2.03159 2.02518 1.955 1.84055 GeneID:7799,Genbank:XM_017002264.2,HGNC:HGNC:9347,MIM:601196 PR/SET domain 2 hsa00310 Lysine degradation PRDM4 902.062522553345 949.673444393936 854.451600712754 0.899732013943013 -0.152432737586849 0.327417198305018 1 7.47197 7.43838 7.27216 6.24522 GeneID:11108,Genbank:NM_012406.3,HGNC:HGNC:9348,MIM:605780 PR/SET domain 4 GO:0000978,GO:0001077,GO:0005737,GO:0006366,GO:0007165,GO:0008168,GO:0008270,GO:0008283,GO:0035097,GO:0043985,GO:1990226 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|cytoplasm|transcription from RNA polymerase II promoter|signal transduction|methyltransferase activity|zinc ion binding|cell proliferation|histone methyltransferase complex|histone H4-R3 methylation|histone methyltransferase binding hsa04722 Neurotrophin signaling pathway PRDM5 52.151849518687 53.4167658124977 50.8869332248762 0.952639727449961 -0.069997380953485 0.888256283411304 1 0.130169 0.170685 0.157472 0.157992 GeneID:11107,Genbank:XM_011531569.3,HGNC:HGNC:9349,MIM:614161 PR/SET domain 5 GO:0000122,GO:0000278,GO:0000978,GO:0001078,GO:0005634,GO:0005730,GO:0006351,GO:0008168,GO:0016575,GO:0016604,GO:0043565,GO:0044212,GO:0045892,GO:0046872,GO:0051567,GO:0070491,GO:1990830 negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|nucleolus|transcription, DNA-templated|methyltransferase activity|histone deacetylation|nuclear body|sequence-specific DNA binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|histone H3-K9 methylation|repressing transcription factor binding|cellular response to leukemia inhibitory factor PRDM6 39.7216733057025 30.0090083781301 49.4343382332749 1.64731661940891 0.720117872216965 0.106977830407025 1 0.132681 0.0950307 0.222679 0.191534 GeneID:93166,Genbank:NM_001136239.3,HGNC:HGNC:9350,MIM:616982 PR/SET domain 6 GO:0003676,GO:0005634,GO:0006351,GO:0018024,GO:0022008,GO:0042803,GO:0045892,GO:0046872,GO:0051151 nucleic acid binding|nucleus|transcription, DNA-templated|histone-lysine N-methyltransferase activity|neurogenesis|protein homodimerization activity|negative regulation of transcription, DNA-templated|metal ion binding|negative regulation of smooth muscle cell differentiation hsa00310 Lysine degradation PRDM7 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00702401 0 0 GeneID:11105,Genbank:XM_011522829.1,HGNC:HGNC:9351,MIM:609759 PR/SET domain 7 GO:0003676,GO:0005634,GO:0005694,GO:0006355,GO:0018024 nucleic acid binding|nucleus|chromosome|regulation of transcription, DNA-templated|histone-lysine N-methyltransferase activity hsa00310 Lysine degradation PRDM8 22.3537389191154 20.9574004245808 23.75007741365 1.1332549329827 0.180472441192302 0.803961791166245 1 0.111987 0.106828 0.199019 0.137583 GeneID:56978,Genbank:XM_011532135.2,HGNC:HGNC:13993,MIM:616639 PR/SET domain 8 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008168,GO:0014003,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|methyltransferase activity|oligodendrocyte development|metal ion binding PRDM9 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00734547 0 GeneID:56979,Genbank:NM_020227.3,HGNC:HGNC:13994,MIM:609760 PR/SET domain 9 GO:0003676,GO:0005654,GO:0005694,GO:0006311,GO:0006351,GO:0006355,GO:0010845,GO:0018024,GO:0046872 nucleic acid binding|nucleoplasm|chromosome|meiotic gene conversion|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of reciprocal meiotic recombination|histone-lysine N-methyltransferase activity|metal ion binding hsa00310 Lysine degradation PRDX1 26235.8394243088 26566.9001236167 25904.7787250009 0.975077205261628 -0.036411640908844 0.825467880876414 1 727.226 741.853 673.708 788.231 GeneID:5052,Genbank:NM_001202431.1,HGNC:HGNC:9352,MIM:176763 peroxiredoxin 1 hsa04146 Peroxisome PRDX2 6709.60451576417 6836.51032137329 6582.69871015506 0.962874098145551 -0.0545809259522618 0.70455066543042 1 302.373 319.147 286.268 322.075 GeneID:7001,Genbank:NM_005809.5,HGNC:HGNC:9353,MIM:600538 peroxiredoxin 2 PRDX3 4545.70626613242 5464.82654796341 3626.58598430142 0.66362325546324 -0.591563651098674 9.4962201118984e-05 0.0220422407698789 162.07 156.991 94.9987 115.96 GeneID:10935,Genbank:NM_001302272.1,HGNC:HGNC:9354,MIM:604769 peroxiredoxin 3 PRDX4 1820.80345723565 1493.87387027723 2147.73304419408 1.43769369484688 0.523756337810116 0.000289297887650079 0.0450711837493147 41.41 42.4749 58.7379 64.3448 GeneID:10549,Genbank:XM_005274438.1,HGNC:HGNC:17169,MIM:300927 peroxiredoxin 4 GO:0005576,GO:0005634,GO:0005739,GO:0005790,GO:0005829,GO:0007252,GO:0007283,GO:0008379,GO:0008584,GO:0019471,GO:0022417,GO:0030198,GO:0034774,GO:0042803,GO:0043312,GO:0045454,GO:0070062,GO:0072593,GO:1904813,GO:2000255 extracellular region|nucleus|mitochondrion|smooth endoplasmic reticulum|cytosol|I-kappaB phosphorylation|spermatogenesis|thioredoxin peroxidase activity|male gonad development|4-hydroxyproline metabolic process|protein maturation by protein folding|extracellular matrix organization|secretory granule lumen|protein homodimerization activity|neutrophil degranulation|cell redox homeostasis|extracellular exosome|reactive oxygen species metabolic process|ficolin-1-rich granule lumen|negative regulation of male germ cell proliferation PRDX5 4414.41697051912 4318.9358500438 4509.89809099445 1.0442151139959 0.06241894555401 0.818361536454898 1 206.189 235.67 211.309 254.632 GeneID:25824,Genbank:NM_012094.4,HGNC:HGNC:9355,MIM:606583 peroxiredoxin 5 hsa04146 Peroxisome PRDX6 7980.69624197788 7765.31733288774 8196.07515106802 1.05547201739663 0.0778883305578693 0.554732927425569 1 201.719 211.799 225.737 212.403 GeneID:9588,Genbank:NM_004905.2,HGNC:HGNC:16753,MIM:602316 peroxiredoxin 6 PREB 1558.76036221306 1608.37605654502 1509.14466788109 0.938303366143682 -0.0918736539463229 0.513074394731575 1 33.2404 34.6875 33.5345 30.8626 GeneID:10113,Genbank:NM_001330484.1,HGNC:HGNC:9356,MIM:606395 prolactin regulatory element binding GO:0000139,GO:0003400,GO:0003677,GO:0005085,GO:0005090,GO:0005096,GO:0005634,GO:0005789,GO:0006351,GO:0006355,GO:0006888,GO:0009306,GO:0016020,GO:0030176,GO:0032527,GO:0036498,GO:0048208,GO:0051020,GO:0070971 Golgi membrane|regulation of COPII vesicle coating|DNA binding|guanyl-nucleotide exchange factor activity|Sar guanyl-nucleotide exchange factor activity|GTPase activator activity|nucleus|endoplasmic reticulum membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|ER to Golgi vesicle-mediated transport|protein secretion|membrane|integral component of endoplasmic reticulum membrane|protein exit from endoplasmic reticulum|IRE1-mediated unfolded protein response|COPII vesicle coating|GTPase binding|endoplasmic reticulum exit site hsa04141 Protein processing in endoplasmic reticulum PRELID1 6824.14457854325 6824.98873909973 6823.30041798677 0.999752626535002 -0.000356928620354863 0.978607834201165 1 211.172 225.249 219.13 226.672 GeneID:27166,Genbank:NM_013237.3,HGNC:HGNC:30255,MIM:605733 PRELI domain containing 1 GO:0005654,GO:0005739,GO:0005758,GO:0006915,GO:0006955,GO:0007275,GO:0010917,GO:0010950,GO:0015914,GO:0042981,GO:0043066,GO:0043234,GO:0045580,GO:0051881,GO:0070234,GO:0090201,GO:0097035,GO:1901857,GO:2001140 nucleoplasm|mitochondrion|mitochondrial intermembrane space|apoptotic process|immune response|multicellular organism development|negative regulation of mitochondrial membrane potential|positive regulation of endopeptidase activity|phospholipid transport|regulation of apoptotic process|negative regulation of apoptotic process|protein complex|regulation of T cell differentiation|regulation of mitochondrial membrane potential|positive regulation of T cell apoptotic process|negative regulation of release of cytochrome c from mitochondria|regulation of membrane lipid distribution|positive regulation of cellular respiration|positive regulation of phospholipid transport PRELID2 197.409450215164 224.227103028989 170.591797401339 0.760799185722363 -0.394412392793694 0.0912252063793776 0.981897113825344 0.46113 0.391158 0.330466 0.310621 GeneID:153768,Genbank:XM_017009133.1,HGNC:HGNC:28306 PRELI domain containing 2 GO:0005758,GO:1990050 mitochondrial intermembrane space|phosphatidic acid transporter activity PRELID3A 82.015364853284 84.5499958185974 79.4807338879707 0.940044208381716 -0.089199489465875 0.818194574531374 1 1.77547 1.05001 1.45186 1.1745 GeneID:10650,Genbank:NM_001142405.1,HGNC:HGNC:24639,MIM:616545 PRELI domain containing 3A GO:0005758,GO:0015914,GO:1903955,GO:1990050 mitochondrial intermembrane space|phospholipid transport|positive regulation of protein targeting to mitochondrion|phosphatidic acid transporter activity PRELID3B 625.921378707628 668.790163836633 583.052593578623 0.871801986790355 -0.197927603366447 0.243911188936867 1 11.5977 10.6435 10.7707 8.39338 GeneID:51012,Genbank:NM_001256403.1,HGNC:HGNC:15892 PRELI domain containing 3B GO:0005758,GO:1990050 mitochondrial intermembrane space|phosphatidic acid transporter activity PRELP 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:5549,Genbank:NM_002725.3,HGNC:HGNC:9357,MIM:601914 proline and arginine rich end leucine rich repeat protein GO:0001501,GO:0005201,GO:0005576,GO:0005578,GO:0005615,GO:0005796,GO:0007569,GO:0008201,GO:0018146,GO:0031012,GO:0042340,GO:0043202,GO:0070062,GO:1903561 skeletal system development|extracellular matrix structural constituent|extracellular region|proteinaceous extracellular matrix|extracellular space|Golgi lumen|cell aging|heparin binding|keratan sulfate biosynthetic process|extracellular matrix|keratan sulfate catabolic process|lysosomal lumen|extracellular exosome|extracellular vesicle PREP 3515.47953025593 3438.0485963624 3592.91046414946 1.04504353660123 0.0635630463543298 0.649603281022602 1 13.9932 15.0941 15.402 15.8912 GeneID:5550,Genbank:NM_002726.4,HGNC:HGNC:9358,MIM:600400 prolyl endopeptidase GO:0004252,GO:0005634,GO:0005737,GO:0005829,GO:0006508,GO:0008236,GO:0016020,GO:0070008 serine-type endopeptidase activity|nucleus|cytoplasm|cytosol|proteolysis|serine-type peptidase activity|membrane|serine-type exopeptidase activity hsa04614 Renin-angiotensin system PREPL 536.893868494856 620.177042493484 453.610694496227 0.731421293301087 -0.451225467534416 0.0646139807891773 0.90091963811897 3.67373 2.86204 2.44141 2.30822 GeneID:9581,Genbank:NM_001171617.1,HGNC:HGNC:30228,MIM:609557 prolyl endopeptidase like GO:0004252,GO:0005794,GO:0005829,GO:0005856,GO:0070008,GO:2000300 serine-type endopeptidase activity|Golgi apparatus|cytosol|cytoskeleton|serine-type exopeptidase activity|regulation of synaptic vesicle exocytosis PREX1 805.150104061931 776.75874274556 833.541465378302 1.07310213520357 0.10178739477036 0.528869157033131 1 3.55389 3.7286 3.93542 3.9321 GeneID:57580,Genbank:XM_011528934.2,HGNC:HGNC:32594,MIM:606905 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 GO:0005085,GO:0005089,GO:0005096,GO:0005543,GO:0005829,GO:0005886,GO:0006469,GO:0006801,GO:0007186,GO:0019899,GO:0030041,GO:0030217,GO:0030335,GO:0030426,GO:0030593,GO:0030676,GO:0030833,GO:0032007,GO:0035023,GO:0035556,GO:0042119,GO:0043065,GO:0043198,GO:0048471,GO:0050773,GO:0051056,GO:1900026 guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|phospholipid binding|cytosol|plasma membrane|negative regulation of protein kinase activity|superoxide metabolic process|G-protein coupled receptor signaling pathway|enzyme binding|actin filament polymerization|T cell differentiation|positive regulation of cell migration|growth cone|neutrophil chemotaxis|Rac guanyl-nucleotide exchange factor activity|regulation of actin filament polymerization|negative regulation of TOR signaling|regulation of Rho protein signal transduction|intracellular signal transduction|neutrophil activation|positive regulation of apoptotic process|dendritic shaft|perinuclear region of cytoplasm|regulation of dendrite development|regulation of small GTPase mediated signal transduction|positive regulation of substrate adhesion-dependent cell spreading hsa04062,hsa05167 Chemokine signaling pathway|Kaposi sarcoma-associated herpesvirus infection PREX2 9.89936824288676 6.7071121482403 13.0916243375332 1.95190180933056 0.964880479768167 0.423821527924486 1 0.0184015 0.014208 0.0747028 0.00990671 GeneID:80243,Genbank:XM_011517612.3,HGNC:HGNC:22950,MIM:612139 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 GO:0005096,GO:0005737,GO:0005829,GO:0005886,GO:0006469,GO:0007186,GO:0008344,GO:0014065,GO:0030676,GO:0032007,GO:0035023,GO:0048813 GTPase activator activity|cytoplasm|cytosol|plasma membrane|negative regulation of protein kinase activity|G-protein coupled receptor signaling pathway|adult locomotory behavior|phosphatidylinositol 3-kinase signaling|Rac guanyl-nucleotide exchange factor activity|negative regulation of TOR signaling|regulation of Rho protein signal transduction|dendrite morphogenesis PRG4 1.24125200715389 1.02816907859967 1.45433493570811 1.4144900541931 0.500282032643154 1 1 0 0 0 0 GeneID:10216,Genbank:NM_005807.4,HGNC:HGNC:9364,MIM:604283 proteoglycan 4 GO:0005044,GO:0006955,GO:0008283,GO:0030247,GO:0031012 scavenger receptor activity|immune response|cell proliferation|polysaccharide binding|extracellular matrix PRH1 5.67186050041724 5.04479284362845 6.29892815720603 1.248599962863 0.320311327997095 0.88269045377329 1 0.71663 0.341037 0.448931 0.351167 GeneID:5554,Genbank:NM_001291315.1,HGNC:HGNC:9366,MIM:168730 proline rich protein HaeIII subfamily 1 hsa04970 Salivary secretion PRH1-TAS2R14 7.44414052118485 5.67894306964064 9.20933797272905 1.62166407724031 0.697475000633304 0.546138229290646 1 1.10135 1.39123 1.84369 1.21952 GeneID:106707243,Genbank:NM_001316893.1 PRH1-TAS2R14 readthrough GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0008527,GO:0016021,GO:0033038 detection of chemical stimulus involved in sensory perception of bitter taste|G-protein coupled receptor activity|plasma membrane|G-protein coupled receptor signaling pathway|taste receptor activity|integral component of membrane|bitter taste receptor activity PRICKLE1 1692.72874797052 1816.25831552089 1569.19918042014 0.863973569734269 -0.210940916059421 0.136564678982175 1 13.8434 14.7448 12.5847 12.5701 GeneID:144165,Genbank:NM_153026.2,HGNC:HGNC:17019,MIM:608500 prickle planar cell polarity protein 1 GO:0001843,GO:0005634,GO:0005829,GO:0006606,GO:0008270,GO:0031398,GO:0031965,GO:0032436,GO:0035904,GO:0045892,GO:0060071,GO:0060976,GO:0090090,GO:2000691 neural tube closure|nucleus|cytosol|protein import into nucleus|zinc ion binding|positive regulation of protein ubiquitination|nuclear membrane|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|aorta development|negative regulation of transcription, DNA-templated|Wnt signaling pathway, planar cell polarity pathway|coronary vasculature development|negative regulation of canonical Wnt signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation hsa04310 Wnt signaling pathway PRICKLE2 608.704499154788 567.463087492754 649.945910816823 1.14535363646031 0.195793109935364 0.238075581493707 1 1.04752 1.02813 1.34635 1.04604 GeneID:166336,Genbank:NM_198859.3,HGNC:HGNC:20340,MIM:608501 prickle planar cell polarity protein 2 GO:0005737,GO:0008270,GO:0031965,GO:0060071 cytoplasm|zinc ion binding|nuclear membrane|Wnt signaling pathway, planar cell polarity pathway hsa04310 Wnt signaling pathway PRICKLE3 253.975823338786 280.200087055752 227.75155962182 0.812817590511682 -0.298996470497062 0.161116128701769 1 3.39986 3.46171 2.71771 3.10054 GeneID:4007,Genbank:NM_006150.4,HGNC:HGNC:6645,MIM:300111 prickle planar cell polarity protein 3 GO:0005634,GO:0005737,GO:0005813,GO:0005886,GO:0007275,GO:0008270,GO:0030030 nucleus|cytoplasm|centrosome|plasma membrane|multicellular organism development|zinc ion binding|cell projection organization hsa04310 Wnt signaling pathway PRICKLE4 93.4764131037256 105.046750806545 81.9060754009066 0.779710698065719 -0.358989165639563 0.335676308366415 1 1.17591 2.05994 1.31727 1.20706 GeneID:29964,Genbank:NM_013397.5,HGNC:HGNC:16805,MIM:611389 prickle planar cell polarity protein 4 GO:0005634,GO:0008270 nucleus|zinc ion binding hsa04310 Wnt signaling pathway PRIM1 466.950167532491 476.426493589125 457.473841475857 0.960219147406162 -0.0585643903087944 0.765574364335895 1 10.09 9.74209 9.32717 10.0564 GeneID:5557,Genbank:NM_000946.2,HGNC:HGNC:9369,MIM:176635 DNA primase subunit 1 GO:0000082,GO:0003697,GO:0003896,GO:0005654,GO:0005658,GO:0006269,GO:0006270,GO:0016020,GO:0032201,GO:0046872 G1/S transition of mitotic cell cycle|single-stranded DNA binding|DNA primase activity|nucleoplasm|alpha DNA polymerase:primase complex|DNA replication, synthesis of RNA primer|DNA replication initiation|membrane|telomere maintenance via semi-conservative replication|metal ion binding hsa00230,hsa00240,hsa03030 Purine metabolism|Pyrimidine metabolism|DNA replication PRIM2 612.522250823722 640.607170897385 584.43733075006 0.91231780926111 -0.132391614822701 0.437057578513024 1 2.31304 2.33763 2.11195 2.27396 GeneID:5558,Genbank:NM_001282488.1,HGNC:HGNC:9370,MIM:176636 DNA primase subunit 2 GO:0000082,GO:0003697,GO:0003887,GO:0003896,GO:0005654,GO:0005658,GO:0006269,GO:0006270,GO:0032201,GO:0046872,GO:0051539 G1/S transition of mitotic cell cycle|single-stranded DNA binding|DNA-directed DNA polymerase activity|DNA primase activity|nucleoplasm|alpha DNA polymerase:primase complex|DNA replication, synthesis of RNA primer|DNA replication initiation|telomere maintenance via semi-conservative replication|metal ion binding|4 iron, 4 sulfur cluster binding hsa00230,hsa00240,hsa03030 Purine metabolism|Pyrimidine metabolism|DNA replication PRIMPOL 80.1487722272533 83.7237404938454 76.5738039606613 0.914600846892289 -0.128785839850576 0.713236308637749 1 1.06641 0.995034 0.865769 0.86421 GeneID:201973,Genbank:NM_001345891.1,HGNC:HGNC:26575,MIM:615421 primase and DNA directed polymerase GO:0003682,GO:0003887,GO:0003896,GO:0005634,GO:0005759,GO:0006264,GO:0009411,GO:0019985,GO:0030145,GO:0031297 chromatin binding|DNA-directed DNA polymerase activity|DNA primase activity|nucleus|mitochondrial matrix|mitochondrial DNA replication|response to UV|translesion synthesis|manganese ion binding|replication fork processing PRKAA1 1054.55060710478 1108.16333597574 1000.93787823381 0.903240385003793 -0.146818102640302 0.647098646398489 1 6.90261 6.05429 7.17522 4.65415 GeneID:5562,Genbank:NM_001355036.1,HGNC:HGNC:9376,MIM:602739 protein kinase AMP-activated catalytic subunit alpha 1 GO:0000187,GO:0001666,GO:0003682,GO:0004672,GO:0004679,GO:0004691,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006006,GO:0006351,GO:0006355,GO:0006468,GO:0006633,GO:0006695,GO:0007050,GO:0007165,GO:0008022,GO:0008284,GO:0008610,GO:0009411,GO:0009631,GO:0010332,GO:0010508,GO:0010628,GO:0014823,GO:0016055,GO:0016236,GO:0016241,GO:0016324,GO:0016607,GO:0019395,GO:0031000,GO:0031588,GO:0031669,GO:0032007,GO:0033135,GO:0035174,GO:0042149,GO:0042593,GO:0042752,GO:0043066,GO:0045542,GO:0045821,GO:0046318,GO:0046872,GO:0047322,GO:0048511,GO:0048643,GO:0050321,GO:0050405,GO:0050995,GO:0051291,GO:0055089,GO:0060627,GO:0061762,GO:0070301,GO:0071361,GO:0071380,GO:0071417,GO:0071456,GO:1901563,GO:1901796,GO:2000505,GO:2001274 activation of MAPK activity|response to hypoxia|chromatin binding|protein kinase activity|AMP-activated protein kinase activity|cAMP-dependent protein kinase activity|ATP binding|intracellular|nucleus|nucleoplasm|cytoplasm|cytosol|glucose metabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|fatty acid biosynthetic process|cholesterol biosynthetic process|cell cycle arrest|signal transduction|protein C-terminus binding|positive regulation of cell proliferation|lipid biosynthetic process|response to UV|cold acclimation|response to gamma radiation|positive regulation of autophagy|positive regulation of gene expression|response to activity|Wnt signaling pathway|macroautophagy|regulation of macroautophagy|apical plasma membrane|nuclear speck|fatty acid oxidation|response to caffeine|nucleotide-activated protein kinase complex|cellular response to nutrient levels|negative regulation of TOR signaling|regulation of peptidyl-serine phosphorylation|histone serine kinase activity|cellular response to glucose starvation|glucose homeostasis|regulation of circadian rhythm|negative regulation of apoptotic process|positive regulation of cholesterol biosynthetic process|positive regulation of glycolytic process|negative regulation of glucosylceramide biosynthetic process|metal ion binding|[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity|rhythmic process|positive regulation of skeletal muscle tissue development|tau-protein kinase activity|[acetyl-CoA carboxylase] kinase activity|negative regulation of lipid catabolic process|protein heterooligomerization|fatty acid homeostasis|regulation of vesicle-mediated transport|CAMKK-AMPK signaling cascade|cellular response to hydrogen peroxide|cellular response to ethanol|cellular response to prostaglandin E stimulus|cellular response to organonitrogen compound|cellular response to hypoxia|response to camptothecin|regulation of signal transduction by p53 class mediator|regulation of energy homeostasis|negative regulation of glucose import in response to insulin stimulus hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410,hsa05418 FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hypertrophic cardiomyopathy (HCM)|Fluid shear stress and atherosclerosis PRKAA2 134.627048029708 102.999204303598 166.254891755817 1.61413763222643 0.690763597738966 0.0645960646051923 0.90091963811897 0.417312 0.324934 0.73911 0.502327 GeneID:5563,Genbank:NM_006252.3,HGNC:HGNC:9377,MIM:600497 protein kinase AMP-activated catalytic subunit alpha 2 GO:0003682,GO:0004672,GO:0004674,GO:0004679,GO:0004712,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006351,GO:0006355,GO:0006468,GO:0006633,GO:0006695,GO:0006853,GO:0006950,GO:0007050,GO:0007165,GO:0008610,GO:0010508,GO:0014850,GO:0016055,GO:0016236,GO:0016239,GO:0016241,GO:0016607,GO:0031588,GO:0031669,GO:0032007,GO:0035174,GO:0035404,GO:0035556,GO:0035690,GO:0042149,GO:0042304,GO:0042593,GO:0042752,GO:0043066,GO:0045821,GO:0046872,GO:0047322,GO:0048511,GO:0050405,GO:0055089,GO:0071380,GO:1901796,GO:2000505 chromatin binding|protein kinase activity|protein serine/threonine kinase activity|AMP-activated protein kinase activity|protein serine/threonine/tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|fatty acid biosynthetic process|cholesterol biosynthetic process|carnitine shuttle|response to stress|cell cycle arrest|signal transduction|lipid biosynthetic process|positive regulation of autophagy|response to muscle activity|Wnt signaling pathway|macroautophagy|positive regulation of macroautophagy|regulation of macroautophagy|nuclear speck|nucleotide-activated protein kinase complex|cellular response to nutrient levels|negative regulation of TOR signaling|histone serine kinase activity|histone-serine phosphorylation|intracellular signal transduction|cellular response to drug|cellular response to glucose starvation|regulation of fatty acid biosynthetic process|glucose homeostasis|regulation of circadian rhythm|negative regulation of apoptotic process|positive regulation of glycolytic process|metal ion binding|[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity|rhythmic process|[acetyl-CoA carboxylase] kinase activity|fatty acid homeostasis|cellular response to prostaglandin E stimulus|regulation of signal transduction by p53 class mediator|regulation of energy homeostasis hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410,hsa05418 FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hypertrophic cardiomyopathy (HCM)|Fluid shear stress and atherosclerosis PRKAB1 588.397229411686 615.604737743306 561.189721080065 0.911607215917933 -0.133515750442319 0.429716661496512 1 10.5191 10.2871 9.84207 9.75818 GeneID:5564,Genbank:XM_005253909.1,HGNC:HGNC:9378,MIM:602740 protein kinase AMP-activated non-catalytic subunit beta 1 hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410 FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hypertrophic cardiomyopathy (HCM) PRKAB2 990.994165194134 1015.56250931858 966.425821069692 0.95161628378557 -0.0715481359283416 0.64788380394956 1 6.78503 6.72646 7.29836 5.72726 GeneID:5565,Genbank:XM_011509729.2,HGNC:HGNC:9379,MIM:602741 protein kinase AMP-activated non-catalytic subunit beta 2 GO:0005654,GO:0005829,GO:0006468,GO:0006633,GO:0006853,GO:0007050,GO:0007165,GO:0016236,GO:0016241,GO:0031588,GO:0042304,GO:0042802,GO:1901796 nucleoplasm|cytosol|protein phosphorylation|fatty acid biosynthetic process|carnitine shuttle|cell cycle arrest|signal transduction|macroautophagy|regulation of macroautophagy|nucleotide-activated protein kinase complex|regulation of fatty acid biosynthetic process|identical protein binding|regulation of signal transduction by p53 class mediator hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410 FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hypertrophic cardiomyopathy (HCM) PRKACA 3359.21684509421 3218.53889390849 3499.89479627993 1.08741727586513 0.120905653615546 0.380082872952852 1 31.2673 31.9052 34.8447 35.1087 GeneID:5566,Genbank:NM_002730.3,HGNC:HGNC:9380,MIM:601639 protein kinase cAMP-activated catalytic subunit alpha hsa01522,hsa04010,hsa04014,hsa04020,hsa04024,hsa04062,hsa04114,hsa04140,hsa04211,hsa04213,hsa04261,hsa04270,hsa04310,hsa04340,hsa04371,hsa04530,hsa04540,hsa04611,hsa04713,hsa04714,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04742,hsa04750,hsa04910,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04961,hsa04962,hsa04970,hsa04971,hsa04976,hsa05012,hsa05020,hsa05030,hsa05031,hsa05032,hsa05034,hsa05110,hsa05146,hsa05163,hsa05165,hsa05166,hsa05200,hsa05203,hsa05205,hsa05414 Endocrine resistance|MAPK signaling pathway|Ras signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Oocyte meiosis|Autophagy - animal|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Hedgehog signaling pathway|Apelin signaling pathway|Tight junction|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Bile secretion|Parkinson disease|Prion diseases|Cocaine addiction|Amphetamine addiction|Morphine addiction|Alcoholism|Vibrio cholerae infection|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Dilated cardiomyopathy (DCM) PRKACB 421.756906850495 447.512280873641 396.001532827349 0.88489534198764 -0.176421259492813 0.576763552561736 1 3.22082 2.6234 3.04803 2.03907 GeneID:5567,Genbank:NM_002731.3,HGNC:HGNC:9381,MIM:176892 protein kinase cAMP-activated catalytic subunit beta hsa01522,hsa04010,hsa04014,hsa04020,hsa04024,hsa04062,hsa04114,hsa04140,hsa04211,hsa04213,hsa04261,hsa04270,hsa04310,hsa04340,hsa04371,hsa04530,hsa04540,hsa04611,hsa04713,hsa04714,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04740,hsa04742,hsa04750,hsa04910,hsa04911,hsa04912,hsa04913,hsa04914,hsa04915,hsa04916,hsa04918,hsa04919,hsa04921,hsa04922,hsa04923,hsa04924,hsa04925,hsa04926,hsa04927,hsa04928,hsa04934,hsa04961,hsa04962,hsa04970,hsa04971,hsa04976,hsa05012,hsa05020,hsa05030,hsa05031,hsa05032,hsa05110,hsa05146,hsa05163,hsa05165,hsa05166,hsa05200,hsa05203,hsa05205,hsa05414 Endocrine resistance|MAPK signaling pathway|Ras signaling pathway|Calcium signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Oocyte meiosis|Autophagy - animal|Longevity regulating pathway|Longevity regulating pathway - multiple species|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Hedgehog signaling pathway|Apelin signaling pathway|Tight junction|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Olfactory transduction|Taste transduction|Inflammatory mediator regulation of TRP channels|Insulin signaling pathway|Insulin secretion|GnRH signaling pathway|Ovarian steroidogenesis|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Regulation of lipolysis in adipocytes|Renin secretion|Aldosterone synthesis and secretion|Relaxin signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Salivary secretion|Gastric acid secretion|Bile secretion|Parkinson disease|Prion diseases|Cocaine addiction|Amphetamine addiction|Morphine addiction|Vibrio cholerae infection|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Dilated cardiomyopathy (DCM) PRKAG1 1460.83084476068 1478.49936037292 1443.16232914844 0.976099393634117 -0.0349000337774429 0.805027981837122 1 16.2983 16.7418 15.3927 16.0415 GeneID:5571,Genbank:XM_005269019.4,HGNC:HGNC:9385,MIM:602742 protein kinase AMP-activated non-catalytic subunit gamma 1 GO:0004672,GO:0004691,GO:0005524,GO:0005654,GO:0005829,GO:0006110,GO:0006468,GO:0006633,GO:0007050,GO:0007165,GO:0007283,GO:0008603,GO:0010628,GO:0016020,GO:0016208,GO:0016236,GO:0016241,GO:0019901,GO:0031588,GO:0043531,GO:0045860,GO:0051170,GO:0070062,GO:1901796 protein kinase activity|cAMP-dependent protein kinase activity|ATP binding|nucleoplasm|cytosol|regulation of glycolytic process|protein phosphorylation|fatty acid biosynthetic process|cell cycle arrest|signal transduction|spermatogenesis|cAMP-dependent protein kinase regulator activity|positive regulation of gene expression|membrane|AMP binding|macroautophagy|regulation of macroautophagy|protein kinase binding|nucleotide-activated protein kinase complex|ADP binding|positive regulation of protein kinase activity|nuclear import|extracellular exosome|regulation of signal transduction by p53 class mediator hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410 FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hypertrophic cardiomyopathy (HCM) PRKAG2 1771.87514292077 1858.67197942627 1685.07830641527 0.906603384065335 -0.141456548526508 0.319374210538271 1 6.48115 6.62429 5.90712 5.70935 GeneID:51422,Genbank:NM_016203.3,HGNC:HGNC:9386,MIM:602743 protein kinase AMP-activated non-catalytic subunit gamma 2 GO:0004679,GO:0004862,GO:0005524,GO:0005615,GO:0005654,GO:0005829,GO:0005977,GO:0006110,GO:0006469,GO:0006633,GO:0006754,GO:0006853,GO:0007050,GO:0008603,GO:0008607,GO:0010800,GO:0016126,GO:0016208,GO:0016236,GO:0016241,GO:0019217,GO:0019901,GO:0030295,GO:0031588,GO:0035556,GO:0042304,GO:0043531,GO:0045860,GO:0046320,GO:0046324,GO:1901796 AMP-activated protein kinase activity|cAMP-dependent protein kinase inhibitor activity|ATP binding|extracellular space|nucleoplasm|cytosol|glycogen metabolic process|regulation of glycolytic process|negative regulation of protein kinase activity|fatty acid biosynthetic process|ATP biosynthetic process|carnitine shuttle|cell cycle arrest|cAMP-dependent protein kinase regulator activity|phosphorylase kinase regulator activity|positive regulation of peptidyl-threonine phosphorylation|sterol biosynthetic process|AMP binding|macroautophagy|regulation of macroautophagy|regulation of fatty acid metabolic process|protein kinase binding|protein kinase activator activity|nucleotide-activated protein kinase complex|intracellular signal transduction|regulation of fatty acid biosynthetic process|ADP binding|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glucose import|regulation of signal transduction by p53 class mediator hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410 FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hypertrophic cardiomyopathy (HCM) PRKAG3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00787901 0 0 GeneID:53632,Genbank:XM_017004343.2,HGNC:HGNC:9387,MIM:604976 protein kinase AMP-activated non-catalytic subunit gamma 3 GO:0004679,GO:0005524,GO:0005615,GO:0005654,GO:0005829,GO:0005978,GO:0006633,GO:0007050,GO:0015758,GO:0016236,GO:0016241,GO:0019901,GO:0031588,GO:0035556,GO:1901796 AMP-activated protein kinase activity|ATP binding|extracellular space|nucleoplasm|cytosol|glycogen biosynthetic process|fatty acid biosynthetic process|cell cycle arrest|glucose transport|macroautophagy|regulation of macroautophagy|protein kinase binding|nucleotide-activated protein kinase complex|intracellular signal transduction|regulation of signal transduction by p53 class mediator hsa04068,hsa04152,hsa04211,hsa04213,hsa04371,hsa04530,hsa04710,hsa04714,hsa04910,hsa04920,hsa04921,hsa04922,hsa04931,hsa04932,hsa05410 FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Apelin signaling pathway|Tight junction|Circadian rhythm|Thermogenesis|Insulin signaling pathway|Adipocytokine signaling pathway|Oxytocin signaling pathway|Glucagon signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hypertrophic cardiomyopathy (HCM) PRKAR1A 4787.04381467769 4999.49412382651 4574.59350552886 0.915011277586533 -0.128138570050356 0.353848936283104 1 47.5277 41.8489 44.1289 38.2844 GeneID:5573,Genbank:NM_001278433.1,HGNC:HGNC:9388,MIM:188830 protein kinase cAMP-dependent type I regulatory subunit alpha hsa04910 Insulin signaling pathway PRKAR1B 644.85803696638 633.536482862736 656.179591070024 1.03574081180767 0.050663022037312 0.795866800605089 1 4.53158 5.14792 4.83907 4.73035 GeneID:5575,Genbank:XM_011515446.2,HGNC:HGNC:9390,MIM:176911 protein kinase cAMP-dependent type I regulatory subunit beta GO:0003091,GO:0004862,GO:0005829,GO:0005886,GO:0005952,GO:0006468,GO:0007596,GO:0007611,GO:0008603,GO:0030552,GO:0034199,GO:0034236,GO:0071377,GO:0097546,GO:2000480 renal water homeostasis|cAMP-dependent protein kinase inhibitor activity|cytosol|plasma membrane|cAMP-dependent protein kinase complex|protein phosphorylation|blood coagulation|learning or memory|cAMP-dependent protein kinase regulator activity|cAMP binding|activation of protein kinase A activity|protein kinase A catalytic subunit binding|cellular response to glucagon stimulus|ciliary base|negative regulation of cAMP-dependent protein kinase activity hsa04910 Insulin signaling pathway PRKAR2A 4983.50259147773 4147.34997342636 5819.65520952909 1.4032225992062 0.48874388800087 0.000245010752602233 0.0409556523973718 23.6016 24.6185 36.4464 31.5574 GeneID:5576,Genbank:XM_011533942.3,HGNC:HGNC:9391,MIM:176910 protein kinase cAMP-dependent type II regulatory subunit alpha GO:0003091,GO:0004862,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005925,GO:0005952,GO:0007596,GO:0008603,GO:0016020,GO:0019904,GO:0030552,GO:0031588,GO:0031625,GO:0034199,GO:0034236,GO:0035556,GO:0043234,GO:0044853,GO:0070062,GO:0071377,GO:0097546,GO:2000480 renal water homeostasis|cAMP-dependent protein kinase inhibitor activity|cytoplasm|centrosome|cytosol|plasma membrane|focal adhesion|cAMP-dependent protein kinase complex|blood coagulation|cAMP-dependent protein kinase regulator activity|membrane|protein domain specific binding|cAMP binding|nucleotide-activated protein kinase complex|ubiquitin protein ligase binding|activation of protein kinase A activity|protein kinase A catalytic subunit binding|intracellular signal transduction|protein complex|plasma membrane raft|extracellular exosome|cellular response to glucagon stimulus|ciliary base|negative regulation of cAMP-dependent protein kinase activity hsa04910 Insulin signaling pathway PRKAR2B 261.772551147447 273.935020034784 249.610082260111 0.911201796062498 -0.134157504153997 0.533417465405696 1 3.24324 3.18175 3.31976 2.52928 GeneID:5577,Genbank:XM_011516398.1,HGNC:HGNC:9392,MIM:176912 protein kinase cAMP-dependent type II regulatory subunit beta GO:0000086,GO:0003091,GO:0004862,GO:0005737,GO:0005743,GO:0005813,GO:0005829,GO:0005886,GO:0005952,GO:0006631,GO:0007596,GO:0007612,GO:0008603,GO:0010389,GO:0019904,GO:0030552,GO:0031625,GO:0034199,GO:0034236,GO:0035556,GO:0043025,GO:0043197,GO:0043198,GO:0045121,GO:0048471,GO:0070062,GO:0071377,GO:0097338,GO:0097546,GO:0097711,GO:2000480 G2/M transition of mitotic cell cycle|renal water homeostasis|cAMP-dependent protein kinase inhibitor activity|cytoplasm|mitochondrial inner membrane|centrosome|cytosol|plasma membrane|cAMP-dependent protein kinase complex|fatty acid metabolic process|blood coagulation|learning|cAMP-dependent protein kinase regulator activity|regulation of G2/M transition of mitotic cell cycle|protein domain specific binding|cAMP binding|ubiquitin protein ligase binding|activation of protein kinase A activity|protein kinase A catalytic subunit binding|intracellular signal transduction|neuronal cell body|dendritic spine|dendritic shaft|membrane raft|perinuclear region of cytoplasm|extracellular exosome|cellular response to glucagon stimulus|response to clozapine|ciliary base|ciliary basal body-plasma membrane docking|negative regulation of cAMP-dependent protein kinase activity hsa04910 Insulin signaling pathway PRKCA 1605.90566343316 1571.23750820159 1640.57381866472 1.04412847204907 0.062299235456568 0.685982215340482 1 4.10643 4.56374 4.95734 4.11426 GeneID:5578,Genbank:XM_017024836.2,HGNC:HGNC:9393,MIM:176960 protein kinase C alpha GO:0001525,GO:0001938,GO:0002159,GO:0004672,GO:0004674,GO:0004697,GO:0004698,GO:0005178,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0006468,GO:0007077,GO:0007155,GO:0007411,GO:0008270,GO:0010595,GO:0010613,GO:0018105,GO:0019899,GO:0030168,GO:0030335,GO:0031666,GO:0031966,GO:0034351,GO:0035403,GO:0035408,GO:0035556,GO:0035866,GO:0038128,GO:0043488,GO:0043536,GO:0045651,GO:0045766,GO:0045780,GO:0045785,GO:0045931,GO:0048471,GO:0050796,GO:0070062,GO:0070374,GO:0070555,GO:0090330,GO:0097190,GO:0106071,GO:2000707 angiogenesis|positive regulation of endothelial cell proliferation|desmosome assembly|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|calcium-dependent protein kinase C activity|integrin binding|ATP binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|protein phosphorylation|mitotic nuclear envelope disassembly|cell adhesion|axon guidance|zinc ion binding|positive regulation of endothelial cell migration|positive regulation of cardiac muscle hypertrophy|peptidyl-serine phosphorylation|enzyme binding|platelet activation|positive regulation of cell migration|positive regulation of lipopolysaccharide-mediated signaling pathway|mitochondrial membrane|negative regulation of glial cell apoptotic process|histone kinase activity (H3-T6 specific)|histone H3-T6 phosphorylation|intracellular signal transduction|alphav-beta3 integrin-PKCalpha complex|ERBB2 signaling pathway|regulation of mRNA stability|positive regulation of blood vessel endothelial cell migration|positive regulation of macrophage differentiation|positive regulation of angiogenesis|positive regulation of bone resorption|positive regulation of cell adhesion|positive regulation of mitotic cell cycle|perinuclear region of cytoplasm|regulation of insulin secretion|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|response to interleukin-1|regulation of platelet aggregation|apoptotic signaling pathway|positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway|positive regulation of dense core granule biogenesis hsa01521,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04066,hsa04070,hsa04071,hsa04072,hsa04150,hsa04151,hsa04261,hsa04270,hsa04310,hsa04360,hsa04370,hsa04510,hsa04540,hsa04650,hsa04664,hsa04666,hsa04670,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04916,hsa04918,hsa04919,hsa04921,hsa04925,hsa04926,hsa04928,hsa04933,hsa04960,hsa04961,hsa04970,hsa04971,hsa04972,hsa05031,hsa05032,hsa05110,hsa05130,hsa05143,hsa05146,hsa05161,hsa05163,hsa05164,hsa05170,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225,hsa05231 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Adrenergic signaling in cardiomyocytes|Vascular smooth muscle contraction|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Gap junction|Natural killer cell mediated cytotoxicity|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|AGE-RAGE signaling pathway in diabetic complications|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Amphetamine addiction|Morphine addiction|Vibrio cholerae infection|Pathogenic Escherichia coli infection|African trypanosomiasis|Amoebiasis|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma|Choline metabolism in cancer PRKCB 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00399789 GeneID:5579,Genbank:NM_002738.6,HGNC:HGNC:9395,MIM:176970 protein kinase C beta hsa01521,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04062,hsa04064,hsa04066,hsa04070,hsa04071,hsa04150,hsa04270,hsa04310,hsa04370,hsa04510,hsa04540,hsa04650,hsa04662,hsa04666,hsa04670,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04750,hsa04911,hsa04912,hsa04916,hsa04918,hsa04919,hsa04921,hsa04925,hsa04928,hsa04931,hsa04933,hsa04960,hsa04961,hsa04970,hsa04971,hsa04972,hsa04973,hsa05031,hsa05032,hsa05140,hsa05143,hsa05146,hsa05161,hsa05163,hsa05164,hsa05170,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225,hsa05231 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|mTOR signaling pathway|Vascular smooth muscle contraction|Wnt signaling pathway|VEGF signaling pathway|Focal adhesion|Gap junction|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|GnRH signaling pathway|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Carbohydrate digestion and absorption|Amphetamine addiction|Morphine addiction|Leishmaniasis|African trypanosomiasis|Amoebiasis|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma|Choline metabolism in cancer PRKCD 792.170171954644 860.828475817308 723.51186809198 0.840483195453132 -0.250709120254942 0.111890552164298 1 8.84332 8.73263 7.15581 7.72453 GeneID:5580,Genbank:NM_001354680.1,HGNC:HGNC:9399,MIM:176977 protein kinase C delta hsa04062,hsa04140,hsa04270,hsa04621,hsa04625,hsa04666,hsa04722,hsa04750,hsa04912,hsa04915,hsa04930,hsa04931,hsa04933 Chemokine signaling pathway|Autophagy - animal|Vascular smooth muscle contraction|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Fc gamma R-mediated phagocytosis|Neurotrophin signaling pathway|Inflammatory mediator regulation of TRP channels|GnRH signaling pathway|Estrogen signaling pathway|Type II diabetes mellitus|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications PRKCE 253.99218735968 280.18148674639 227.80288797297 0.813054747543575 -0.298575594554662 0.149716767280151 1 0.32913 0.384031 0.348277 0.240888 GeneID:5581,Genbank:XM_017004492.2,HGNC:HGNC:9401,MIM:176975 protein kinase C epsilon GO:0002281,GO:0003785,GO:0004674,GO:0004697,GO:0004699,GO:0004871,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005783,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0006915,GO:0007049,GO:0007155,GO:0007165,GO:0008047,GO:0010634,GO:0010763,GO:0010811,GO:0018105,GO:0019899,GO:0030168,GO:0030546,GO:0030838,GO:0031397,GO:0031663,GO:0032024,GO:0032230,GO:0032467,GO:0035276,GO:0035556,GO:0035641,GO:0035669,GO:0038096,GO:0043123,GO:0043278,GO:0043410,GO:0046872,GO:0048471,GO:0050730,GO:0050996,GO:0051209,GO:0051279,GO:0051301,GO:0061178,GO:0070257,GO:0071361,GO:0071380,GO:0071456,GO:0071889,GO:0071944,GO:0090303,GO:1903078,GO:2000650,GO:2001031 macrophage activation involved in immune response|actin monomer binding|protein serine/threonine kinase activity|protein kinase C activity|calcium-independent protein kinase C activity|signal transducer activity|ATP binding|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum|Golgi apparatus|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|apoptotic process|cell cycle|cell adhesion|signal transduction|enzyme activator activity|positive regulation of epithelial cell migration|positive regulation of fibroblast migration|positive regulation of cell-substrate adhesion|peptidyl-serine phosphorylation|enzyme binding|platelet activation|receptor activator activity|positive regulation of actin filament polymerization|negative regulation of protein ubiquitination|lipopolysaccharide-mediated signaling pathway|positive regulation of insulin secretion|positive regulation of synaptic transmission, GABAergic|positive regulation of cytokinesis|ethanol binding|intracellular signal transduction|locomotory exploration behavior|TRAM-dependent toll-like receptor 4 signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to morphine|positive regulation of MAPK cascade|metal ion binding|perinuclear region of cytoplasm|regulation of peptidyl-tyrosine phosphorylation|positive regulation of lipid catabolic process|release of sequestered calcium ion into cytosol|regulation of release of sequestered calcium ion into cytosol|cell division|regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of mucus secretion|cellular response to ethanol|cellular response to prostaglandin E stimulus|cellular response to hypoxia|14-3-3 protein binding|cell periphery|positive regulation of wound healing|positive regulation of protein localization to plasma membrane|negative regulation of sodium ion transmembrane transporter activity|positive regulation of cellular glucuronidation hsa04022,hsa04071,hsa04270,hsa04371,hsa04530,hsa04666,hsa04750,hsa04925,hsa04930,hsa04931,hsa04933,hsa05206 cGMP-PKG signaling pathway|Sphingolipid signaling pathway|Vascular smooth muscle contraction|Apelin signaling pathway|Tight junction|Fc gamma R-mediated phagocytosis|Inflammatory mediator regulation of TRP channels|Aldosterone synthesis and secretion|Type II diabetes mellitus|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|MicroRNAs in cancer PRKCG 2.3170123744118 3.18055978516888 1.45346496365472 0.456984009680402 -1.12978441003813 0.695611227491301 1 0.0763106 0.0131718 0.0140874 0.0131875 GeneID:5582,Genbank:NM_002739.4,HGNC:HGNC:9402,MIM:176980 protein kinase C gamma hsa01521,hsa04010,hsa04012,hsa04014,hsa04015,hsa04020,hsa04066,hsa04070,hsa04071,hsa04150,hsa04270,hsa04310,hsa04370,hsa04510,hsa04540,hsa04650,hsa04666,hsa04670,hsa04713,hsa04720,hsa04723,hsa04724,hsa04725,hsa04726,hsa04727,hsa04728,hsa04730,hsa04750,hsa04911,hsa04916,hsa04918,hsa04919,hsa04921,hsa04925,hsa04928,hsa04960,hsa04961,hsa04970,hsa04971,hsa04972,hsa05031,hsa05032,hsa05143,hsa05146,hsa05161,hsa05163,hsa05170,hsa05200,hsa05205,hsa05206,hsa05214,hsa05223,hsa05225,hsa05231 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Calcium signaling pathway|HIF-1 signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|mTOR signaling pathway|Vascular smooth muscle contraction|Wnt signaling pathway|VEGF signaling pathway|Focal adhesion|Gap junction|Natural killer cell mediated cytotoxicity|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Circadian entrainment|Long-term potentiation|Retrograde endocannabinoid signaling|Glutamatergic synapse|Cholinergic synapse|Serotonergic synapse|GABAergic synapse|Dopaminergic synapse|Long-term depression|Inflammatory mediator regulation of TRP channels|Insulin secretion|Melanogenesis|Thyroid hormone synthesis|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Aldosterone synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Aldosterone-regulated sodium reabsorption|Endocrine and other factor-regulated calcium reabsorption|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Amphetamine addiction|Morphine addiction|African trypanosomiasis|Amoebiasis|Hepatitis B|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Glioma|Non-small cell lung cancer|Hepatocellular carcinoma|Choline metabolism in cancer PRKCH 161.475484727886 152.851200133448 170.099769322325 1.11284549400867 0.154253304718794 0.52525018925034 1 0.684008 0.602525 0.700683 0.725053 GeneID:5583,Genbank:XM_024449661.1,HGNC:HGNC:9403,MIM:605437 protein kinase C eta GO:0004697,GO:0004699,GO:0005524,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0006468,GO:0007165,GO:0010744,GO:0017160,GO:0018105,GO:0019899,GO:0030168,GO:0034351,GO:0035556,GO:0045618,GO:0046872,GO:0050861,GO:0051092,GO:0060252,GO:0070062,GO:0070528,GO:1903078,GO:2000810 protein kinase C activity|calcium-independent protein kinase C activity|ATP binding|cytoplasm|cytosol|plasma membrane|cell-cell junction|protein phosphorylation|signal transduction|positive regulation of macrophage derived foam cell differentiation|Ral GTPase binding|peptidyl-serine phosphorylation|enzyme binding|platelet activation|negative regulation of glial cell apoptotic process|intracellular signal transduction|positive regulation of keratinocyte differentiation|metal ion binding|positive regulation of B cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of glial cell proliferation|extracellular exosome|protein kinase C signaling|positive regulation of protein localization to plasma membrane|regulation of bicellular tight junction assembly hsa04270,hsa04750 Vascular smooth muscle contraction|Inflammatory mediator regulation of TRP channels PRKCI 751.224262709201 845.211800537864 657.236724880538 0.777600034053352 -0.362899812763883 0.120067545603124 1 8.11619 6.97562 6.79813 4.96787 GeneID:5584,Genbank:NM_002740.5,HGNC:HGNC:9404,MIM:600539 protein kinase C iota hsa04015,hsa04144,hsa04390,hsa04530,hsa04611,hsa04910,hsa05165 Rap1 signaling pathway|Endocytosis|Hippo signaling pathway|Tight junction|Platelet activation|Insulin signaling pathway|Human papillomavirus infection PRKCQ 29.8445148912837 30.6049409845653 29.0840887980021 0.950306972088912 -0.0735344808392733 0.907424708143051 1 0.126633 0.176376 0.187603 0.105901 GeneID:5588,Genbank:XM_005252497.4,HGNC:HGNC:9410,MIM:600448 protein kinase C theta GO:0001558,GO:0001772,GO:0004672,GO:0004674,GO:0004697,GO:0005524,GO:0005622,GO:0005815,GO:0005829,GO:0005886,GO:0006355,GO:0006509,GO:0006954,GO:0007411,GO:0016235,GO:0018105,GO:0030168,GO:0032212,GO:0032740,GO:0032753,GO:0035556,GO:0038095,GO:0042102,GO:0045086,GO:0045652,GO:0046627,GO:0046872,GO:0050852,GO:0050870,GO:0051092,GO:0051973,GO:0060326,GO:0070233,GO:0090330,GO:0097194,GO:1904355,GO:2000318,GO:2000570 regulation of cell growth|immunological synapse|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|ATP binding|intracellular|microtubule organizing center|cytosol|plasma membrane|regulation of transcription, DNA-templated|membrane protein ectodomain proteolysis|inflammatory response|axon guidance|aggresome|peptidyl-serine phosphorylation|platelet activation|positive regulation of telomere maintenance via telomerase|positive regulation of interleukin-17 production|positive regulation of interleukin-4 production|intracellular signal transduction|Fc-epsilon receptor signaling pathway|positive regulation of T cell proliferation|positive regulation of interleukin-2 biosynthetic process|regulation of megakaryocyte differentiation|negative regulation of insulin receptor signaling pathway|metal ion binding|T cell receptor signaling pathway|positive regulation of T cell activation|positive regulation of NF-kappaB transcription factor activity|positive regulation of telomerase activity|cell chemotaxis|negative regulation of T cell apoptotic process|regulation of platelet aggregation|execution phase of apoptosis|positive regulation of telomere capping|positive regulation of T-helper 17 type immune response|positive regulation of T-helper 2 cell activation hsa04064,hsa04140,hsa04270,hsa04658,hsa04659,hsa04660,hsa04750,hsa04920,hsa04931,hsa05162 NF-kappa B signaling pathway|Autophagy - animal|Vascular smooth muscle contraction|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Inflammatory mediator regulation of TRP channels|Adipocytokine signaling pathway|Insulin resistance|Measles PRKCSH 9449.82393517235 9358.34459884379 9541.3032715009 1.0195503243896 0.0279329876698357 0.851585430501212 1 103.119 108.361 112.376 107.938 GeneID:5589,Genbank:NM_001289103.1,HGNC:HGNC:9411,MIM:177060 protein kinase C substrate 80K-H GO:0005080,GO:0005509,GO:0005622,GO:0005783,GO:0005788,GO:0006457,GO:0006491,GO:0035556,GO:0043687,GO:0044267,GO:0044325,GO:0051219 protein kinase C binding|calcium ion binding|intracellular|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|N-glycan processing|intracellular signal transduction|post-translational protein modification|cellular protein metabolic process|ion channel binding|phosphoprotein binding hsa04141 Protein processing in endoplasmic reticulum PRKCZ 38.3158461525397 38.8302936133626 37.8013986917168 0.973502777705194 -0.0387429994797566 0.953529302649823 1 0.138439 0.157378 0.127902 0.119659 GeneID:5590,Genbank:NM_002744.5,HGNC:HGNC:9412,MIM:176982 protein kinase C zeta GO:0000226,GO:0001954,GO:0004672,GO:0004674,GO:0004697,GO:0005524,GO:0005635,GO:0005737,GO:0005768,GO:0005815,GO:0005829,GO:0005886,GO:0005911,GO:0005923,GO:0006468,GO:0006954,GO:0007165,GO:0007179,GO:0007616,GO:0008284,GO:0008286,GO:0015459,GO:0016020,GO:0016324,GO:0016363,GO:0016477,GO:0018105,GO:0019901,GO:0019904,GO:0030010,GO:0030054,GO:0031252,GO:0031333,GO:0031532,GO:0031584,GO:0031941,GO:0031982,GO:0032148,GO:0032753,GO:0035748,GO:0043066,GO:0043203,GO:0043274,GO:0043560,GO:0045121,GO:0045179,GO:0045630,GO:0046326,GO:0046627,GO:0046628,GO:0046872,GO:0047496,GO:0048471,GO:0050732,GO:0051092,GO:0051291,GO:0051346,GO:0051899,GO:0060081,GO:0060291,GO:0070062,GO:0070374,GO:0070528,GO:0071889,GO:0072659,GO:1990138,GO:2000463,GO:2000553,GO:2000664,GO:2000667,GO:2001181 microtubule cytoskeleton organization|positive regulation of cell-matrix adhesion|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|ATP binding|nuclear envelope|cytoplasm|endosome|microtubule organizing center|cytosol|plasma membrane|cell-cell junction|bicellular tight junction|protein phosphorylation|inflammatory response|signal transduction|transforming growth factor beta receptor signaling pathway|long-term memory|positive regulation of cell proliferation|insulin receptor signaling pathway|potassium channel regulator activity|membrane|apical plasma membrane|nuclear matrix|cell migration|peptidyl-serine phosphorylation|protein kinase binding|protein domain specific binding|establishment of cell polarity|cell junction|cell leading edge|negative regulation of protein complex assembly|actin cytoskeleton reorganization|activation of phospholipase D activity|filamentous actin|vesicle|activation of protein kinase B activity|positive regulation of interleukin-4 production|myelin sheath abaxonal region|negative regulation of apoptotic process|axon hillock|phospholipase binding|insulin receptor substrate binding|membrane raft|apical cortex|positive regulation of T-helper 2 cell differentiation|positive regulation of glucose import|negative regulation of insulin receptor signaling pathway|positive regulation of insulin receptor signaling pathway|metal ion binding|vesicle transport along microtubule|perinuclear region of cytoplasm|negative regulation of peptidyl-tyrosine phosphorylation|positive regulation of NF-kappaB transcription factor activity|protein heterooligomerization|negative regulation of hydrolase activity|membrane depolarization|membrane hyperpolarization|long-term synaptic potentiation|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|protein kinase C signaling|14-3-3 protein binding|protein localization to plasma membrane|neuron projection extension|positive regulation of excitatory postsynaptic potential|positive regulation of T-helper 2 cell cytokine production|positive regulation of interleukin-5 secretion|positive regulation of interleukin-13 secretion|positive regulation of interleukin-10 secretion hsa04015,hsa04062,hsa04071,hsa04144,hsa04360,hsa04390,hsa04530,hsa04611,hsa04910,hsa04926,hsa04930,hsa04931,hsa04933,hsa05165,hsa05418 Rap1 signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Endocytosis|Axon guidance|Hippo signaling pathway|Tight junction|Platelet activation|Insulin signaling pathway|Relaxin signaling pathway|Type II diabetes mellitus|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Human papillomavirus infection|Fluid shear stress and atherosclerosis PRKD1 343.365610706752 307.740138114734 378.991083298769 1.23152958083573 0.300451281196585 0.12176281027341 1 1.20622 1.31391 1.57121 1.38151 GeneID:5587,Genbank:NM_001330069.1,HGNC:HGNC:9407,MIM:605435 protein kinase D1 hsa04015,hsa04925 Rap1 signaling pathway|Aldosterone synthesis and secretion PRKD2 847.442155821581 744.424855872337 950.459455770825 1.27677017804175 0.352498859544339 0.0839521526159455 0.963164524568039 8.1862 8.90921 12.528 9.88489 GeneID:25865,Genbank:NM_001079881.1,HGNC:HGNC:17293,MIM:607074 protein kinase D2 GO:0001525,GO:0001938,GO:0002250,GO:0004672,GO:0004674,GO:0004697,GO:0005080,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006468,GO:0007155,GO:0008219,GO:0010595,GO:0018105,GO:0018107,GO:0030148,GO:0030949,GO:0032743,GO:0032757,GO:0032793,GO:0033138,GO:0035556,GO:0035924,GO:0038033,GO:0043536,GO:0045743,GO:0045766,GO:0045785,GO:0045944,GO:0046777,GO:0046872,GO:0048010,GO:0050852,GO:0050862,GO:0051091,GO:0051092,GO:0061154,GO:0070374,GO:0089700,GO:1901727,GO:1902533,GO:2000573,GO:2001028 angiogenesis|positive regulation of endothelial cell proliferation|adaptive immune response|protein kinase activity|protein serine/threonine kinase activity|protein kinase C activity|protein kinase C binding|ATP binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|plasma membrane|protein phosphorylation|cell adhesion|cell death|positive regulation of endothelial cell migration|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|sphingolipid biosynthetic process|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of interleukin-2 production|positive regulation of interleukin-8 production|positive regulation of CREB transcription factor activity|positive regulation of peptidyl-serine phosphorylation|intracellular signal transduction|cellular response to vascular endothelial growth factor stimulus|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|metal ion binding|vascular endothelial growth factor receptor signaling pathway|T cell receptor signaling pathway|positive regulation of T cell receptor signaling pathway|positive regulation of DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|endothelial tube morphogenesis|positive regulation of ERK1 and ERK2 cascade|protein kinase D signaling|positive regulation of histone deacetylase activity|positive regulation of intracellular signal transduction|positive regulation of DNA biosynthetic process|positive regulation of endothelial cell chemotaxis hsa04015,hsa04925 Rap1 signaling pathway|Aldosterone synthesis and secretion PRKD3 408.21827991323 425.286579997036 391.149979829424 0.919732712544446 -0.120713440580429 0.697284170978989 1 2.62225 2.13018 2.59857 1.84131 GeneID:23683,Genbank:XM_024452776.1,HGNC:HGNC:9408,MIM:607077 protein kinase D3 GO:0004674,GO:0004697,GO:0005524,GO:0005654,GO:0005829,GO:0006468,GO:0007205,GO:0016020,GO:0016301,GO:0030148,GO:0046872,GO:0089700 protein serine/threonine kinase activity|protein kinase C activity|ATP binding|nucleoplasm|cytosol|protein phosphorylation|protein kinase C-activating G-protein coupled receptor signaling pathway|membrane|kinase activity|sphingolipid biosynthetic process|metal ion binding|protein kinase D signaling hsa04015,hsa04925 Rap1 signaling pathway|Aldosterone synthesis and secretion PRKDC 7349.00402757624 7624.62353790212 7073.38451725035 0.927702788483712 -0.108265416968898 0.683171822734732 1 19.6077 18.7473 21.8671 14.2303 GeneID:5591,Genbank:NM_001081640.1,HGNC:HGNC:9413,MIM:600899 protein kinase, DNA-activated, catalytic polypeptide hsa03450,hsa04110 Non-homologous end-joining|Cell cycle PRKG1 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0 0 0.00784098 0 GeneID:5592,Genbank:NM_001098512.2,HGNC:HGNC:9414,MIM:176894 protein kinase, cGMP-dependent, type I GO:0001764,GO:0004674,GO:0004692,GO:0005246,GO:0005524,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0006468,GO:0007165,GO:0016358,GO:0019934,GO:0030036,GO:0030553,GO:0030900,GO:0042802,GO:0043087,GO:0060087,GO:0090331 neuron migration|protein serine/threonine kinase activity|cGMP-dependent protein kinase activity|calcium channel regulator activity|ATP binding|cytoplasm|Golgi apparatus|cytosol|plasma membrane|protein phosphorylation|signal transduction|dendrite development|cGMP-mediated signaling|actin cytoskeleton organization|cGMP binding|forebrain development|identical protein binding|regulation of GTPase activity|relaxation of vascular smooth muscle|negative regulation of platelet aggregation hsa04022,hsa04270,hsa04540,hsa04611,hsa04713,hsa04714,hsa04730,hsa04740,hsa04923,hsa04970 cGMP-PKG signaling pathway|Vascular smooth muscle contraction|Gap junction|Platelet activation|Circadian entrainment|Thermogenesis|Long-term depression|Olfactory transduction|Regulation of lipolysis in adipocytes|Salivary secretion PRKN 24.6151978689333 19.1892199154911 30.0411758223755 1.56552355721994 0.646645217597431 0.253344717450556 1 0.156986 0.10711 0.195823 0.248819 GeneID:5071,Genbank:XM_011535863.1,HGNC:HGNC:8607,MIM:602544 parkin RBR E3 ubiquitin protein ligase hsa04120,hsa04137,hsa04141,hsa05012 Ubiquitin mediated proteolysis|Mitophagy - animal|Protein processing in endoplasmic reticulum|Parkinson disease PRKRA 722.131914307579 756.099308624197 688.164519990962 0.910150971098162 -0.13582222299423 0.394484346267669 1 10.9507 11.579 10.3848 9.58872 GeneID:8575,Genbank:NM_001316362.1,HGNC:HGNC:9438,MIM:603424 protein activator of interferon induced protein kinase EIF2AK2 GO:0003723,GO:0003725,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006955,GO:0008047,GO:0008285,GO:0009615,GO:0010586,GO:0016020,GO:0019899,GO:0030422,GO:0031054,GO:0034599,GO:0035196,GO:0042473,GO:0042474,GO:0042802,GO:0042803,GO:0048471,GO:0048705,GO:0050821,GO:0070578,GO:0070883,GO:2001244 RNA binding|double-stranded RNA binding|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|immune response|enzyme activator activity|negative regulation of cell proliferation|response to virus|miRNA metabolic process|membrane|enzyme binding|production of siRNA involved in RNA interference|pre-miRNA processing|cellular response to oxidative stress|production of miRNAs involved in gene silencing by miRNA|outer ear morphogenesis|middle ear morphogenesis|identical protein binding|protein homodimerization activity|perinuclear region of cytoplasm|skeletal system morphogenesis|protein stabilization|RISC-loading complex|pre-miRNA binding|positive regulation of intrinsic apoptotic signaling pathway PRKRIP1 923.960982494841 893.260449241611 954.661515748071 1.06873814525046 0.0959084173007777 0.638095763635695 1 12.9978 15.917 14.646 16.3743 GeneID:79706,Genbank:NM_024653.3,HGNC:HGNC:21894,MIM:617458 PRKR interacting protein 1 GO:0003014,GO:0003725,GO:0004860,GO:0005730,GO:0006469,GO:0019901,GO:0042326,GO:0070062 renal system process|double-stranded RNA binding|protein kinase inhibitor activity|nucleolus|negative regulation of protein kinase activity|protein kinase binding|negative regulation of phosphorylation|extracellular exosome PRKX 309.474705863936 326.679418001692 292.26999372618 0.894669139286474 -0.160573841964649 0.419152752462483 1 2.028 2.15069 2.21623 1.56468 GeneID:5613,Genbank:NM_005044.4,HGNC:HGNC:9441,MIM:300083 protein kinase, X-linked GO:0001525,GO:0001935,GO:0004691,GO:0005524,GO:0005634,GO:0005737,GO:0007155,GO:0018105,GO:0030099,GO:0030155,GO:0030334,GO:0031589,GO:0043542,GO:0046777,GO:0060562,GO:0060993,GO:2000696 angiogenesis|endothelial cell proliferation|cAMP-dependent protein kinase activity|ATP binding|nucleus|cytoplasm|cell adhesion|peptidyl-serine phosphorylation|myeloid cell differentiation|regulation of cell adhesion|regulation of cell migration|cell-substrate adhesion|endothelial cell migration|protein autophosphorylation|epithelial tube morphogenesis|kidney morphogenesis|regulation of epithelial cell differentiation involved in kidney development PRLR 15.4603980550948 14.4423933750803 16.4784027351094 1.14097451212915 0.190266564075682 0.826190058173544 1 0.0435146 0.0357406 0.0537511 0.044536 GeneID:5618,Genbank:NM_001204318.1,HGNC:HGNC:9446,MIM:176761 prolactin receptor hsa04060,hsa04080,hsa04151,hsa04630,hsa04917 Cytokine-cytokine receptor interaction|Neuroactive ligand-receptor interaction|PI3K-Akt signaling pathway|Jak-STAT signaling pathway|Prolactin signaling pathway PRMT1 6391.77203686612 6893.68396226717 5889.86011146506 0.854384991204039 -0.22704179115039 0.0803558059379844 0.951623427935096 117.505 124.733 101.354 108.527 GeneID:3276,Genbank:XM_017026736.1,HGNC:HGNC:5187,MIM:602950 protein arginine methyltransferase 1 GO:0001701,GO:0003723,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006479,GO:0008170,GO:0008276,GO:0008284,GO:0008327,GO:0008469,GO:0008757,GO:0016020,GO:0016274,GO:0016275,GO:0016571,GO:0018216,GO:0019899,GO:0019919,GO:0030519,GO:0031175,GO:0034709,GO:0035241,GO:0035242,GO:0035247,GO:0042054,GO:0042802,GO:0043234,GO:0043985,GO:0044020,GO:0045648,GO:0045653,GO:0046985,GO:0048273,GO:0097421,GO:1900745 in utero embryonic development|RNA binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|protein methylation|N-methyltransferase activity|protein methyltransferase activity|positive regulation of cell proliferation|methyl-CpG binding|histone-arginine N-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|membrane|protein-arginine N-methyltransferase activity|[cytochrome c]-arginine N-methyltransferase activity|histone methylation|peptidyl-arginine methylation|enzyme binding|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|snoRNP binding|neuron projection development|methylosome|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|peptidyl-arginine omega-N-methylation|histone methyltransferase activity|identical protein binding|protein complex|histone H4-R3 methylation|histone methyltransferase activity (H4-R3 specific)|positive regulation of erythrocyte differentiation|negative regulation of megakaryocyte differentiation|positive regulation of hemoglobin biosynthetic process|mitogen-activated protein kinase p38 binding|liver regeneration|positive regulation of p38MAPK cascade hsa04068,hsa04922 FoxO signaling pathway|Glucagon signaling pathway PRMT2 2484.26468615038 2375.4196151457 2593.10975715507 1.09164281570354 0.12650088527966 0.366156239502715 1 5.97892 6.48939 6.42303 6.98373 GeneID:3275,Genbank:XM_005261111.4,HGNC:HGNC:5186,MIM:601961 protein arginine methyltransferase 2 GO:0003713,GO:0004871,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006479,GO:0007165,GO:0008469,GO:0016274,GO:0016571,GO:0030331,GO:0032088,GO:0033142,GO:0035242,GO:0042054,GO:0042803,GO:0042974,GO:0042975,GO:0043065,GO:0045892,GO:0045893,GO:0046966,GO:0048588,GO:0050681,GO:0060765,GO:2000134 transcription coactivator activity|signal transducer activity|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|protein methylation|signal transduction|histone-arginine N-methyltransferase activity|protein-arginine N-methyltransferase activity|histone methylation|estrogen receptor binding|negative regulation of NF-kappaB transcription factor activity|progesterone receptor binding|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity|protein homodimerization activity|retinoic acid receptor binding|peroxisome proliferator activated receptor binding|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|thyroid hormone receptor binding|developmental cell growth|androgen receptor binding|regulation of androgen receptor signaling pathway|negative regulation of G1/S transition of mitotic cell cycle PRMT3 403.801673879263 435.415400304724 372.187947453801 0.85478820269868 -0.226361098009854 0.222282170269476 1 5.01249 5.03968 4.35357 4.37531 GeneID:10196,Genbank:NM_005788.3,HGNC:HGNC:30163,MIM:603190 protein arginine methyltransferase 3 GO:0003676,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006479,GO:0008168,GO:0008469,GO:0016274,GO:0031397,GO:0035242,GO:0046872 nucleic acid binding|cytoplasm|cytosol|ribosome|regulation of transcription, DNA-templated|protein methylation|methyltransferase activity|histone-arginine N-methyltransferase activity|protein-arginine N-methyltransferase activity|negative regulation of protein ubiquitination|protein-arginine omega-N asymmetric methyltransferase activity|metal ion binding PRMT5 2986.43916293667 3106.81343991818 2866.06488595516 0.922509491278189 -0.116364340408601 0.389558887667162 1 35.4477 35.5409 33.1835 32.7285 GeneID:10419,Genbank:NM_001282955.1,HGNC:HGNC:10894,MIM:604045 protein arginine methyltransferase 5 GO:0000387,GO:0001046,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006353,GO:0006355,GO:0007088,GO:0008168,GO:0008283,GO:0008327,GO:0008469,GO:0016274,GO:0018216,GO:0032403,GO:0032922,GO:0034709,GO:0035097,GO:0035243,GO:0035246,GO:0042118,GO:0042802,GO:0043021,GO:0043234,GO:0043985,GO:0044020,GO:0044030,GO:0045596,GO:0046982,GO:0048714,GO:0070372,GO:0090161,GO:0097421,GO:1901796,GO:1904992 spliceosomal snRNP assembly|core promoter sequence-specific DNA binding|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|DNA-templated transcription, termination|regulation of transcription, DNA-templated|regulation of mitotic nuclear division|methyltransferase activity|cell proliferation|methyl-CpG binding|histone-arginine N-methyltransferase activity|protein-arginine N-methyltransferase activity|peptidyl-arginine methylation|protein complex binding|circadian regulation of gene expression|methylosome|histone methyltransferase complex|protein-arginine omega-N symmetric methyltransferase activity|peptidyl-arginine N-methylation|endothelial cell activation|identical protein binding|ribonucleoprotein complex binding|protein complex|histone H4-R3 methylation|histone methyltransferase activity (H4-R3 specific)|regulation of DNA methylation|negative regulation of cell differentiation|protein heterodimerization activity|positive regulation of oligodendrocyte differentiation|regulation of ERK1 and ERK2 cascade|Golgi ribbon formation|liver regeneration|regulation of signal transduction by p53 class mediator|positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway hsa03013 RNA transport PRMT6 696.653665320681 558.257592060042 835.049738581321 1.49581438830036 0.580931166073111 0.000346346219800848 0.0490892128878794 10.7853 10.1725 17.058 14.7804 GeneID:55170,Genbank:NM_018137.2,HGNC:HGNC:18241,MIM:608274 protein arginine methyltransferase 6 GO:0000122,GO:0003682,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006284,GO:0006351,GO:0008469,GO:0016032,GO:0016049,GO:0016274,GO:0016571,GO:0019919,GO:0034970,GO:0035241,GO:0035242,GO:0042054,GO:0042393,GO:0044020,GO:0045652,GO:0045892,GO:0070611,GO:0070612,GO:0090398 negative regulation of transcription from RNA polymerase II promoter|chromatin binding|nucleus|nucleoplasm|nucleolus|cytosol|base-excision repair|transcription, DNA-templated|histone-arginine N-methyltransferase activity|viral process|cell growth|protein-arginine N-methyltransferase activity|histone methylation|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|histone H3-R2 methylation|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|histone methyltransferase activity|histone binding|histone methyltransferase activity (H4-R3 specific)|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H2A-R3 specific)|cellular senescence PRMT7 695.66621415781 718.681394286914 672.651034028706 0.935951646133988 -0.095494096793071 0.555291882368869 1 3.53211 3.73126 3.64495 3.62894 GeneID:54496,Genbank:NM_001351143.1,HGNC:HGNC:25557,MIM:610087 protein arginine methyltransferase 7 GO:0000387,GO:0001650,GO:0005634,GO:0005654,GO:0005829,GO:0006349,GO:0006351,GO:0006355,GO:0008469,GO:0008757,GO:0016274,GO:0016277,GO:0016571,GO:0018216,GO:0030154,GO:0034969,GO:0035241,GO:0035242,GO:0035243,GO:0042393,GO:0043021,GO:0043046,GO:0043393,GO:0044020 spliceosomal snRNP assembly|fibrillar center|nucleus|nucleoplasm|cytosol|regulation of gene expression by genetic imprinting|transcription, DNA-templated|regulation of transcription, DNA-templated|histone-arginine N-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|protein-arginine N-methyltransferase activity|[myelin basic protein]-arginine N-methyltransferase activity|histone methylation|peptidyl-arginine methylation|cell differentiation|histone arginine methylation|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|histone binding|ribonucleoprotein complex binding|DNA methylation involved in gamete generation|regulation of protein binding|histone methyltransferase activity (H4-R3 specific) PRMT9 115.772755390611 132.191766012085 99.3537447691369 0.751587998000226 -0.411986066133394 0.146476084446647 1 0.75013 0.759797 0.554017 0.467177 GeneID:90826,Genbank:XM_017008823.2,HGNC:HGNC:25099,MIM:616125 protein arginine methyltransferase 9 GO:0005737,GO:0006397,GO:0016274,GO:0035243 cytoplasm|mRNA processing|protein-arginine N-methyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity PRND 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.010729 GeneID:23627,Genbank:NM_012409.3,HGNC:HGNC:15748,MIM:604263 prion like protein doppel GO:0005507,GO:0005576,GO:0005886,GO:0006501,GO:0006878,GO:0007340,GO:0031362,GO:0051260 copper ion binding|extracellular region|plasma membrane|C-terminal protein lipidation|cellular copper ion homeostasis|acrosome reaction|anchored component of external side of plasma membrane|protein homooligomerization PRNP 5844.05097284985 5454.41937866272 6233.68256703697 1.14286822011206 0.192659061337766 0.140494034228365 1 87.7821 83.3283 108.415 89.6861 GeneID:5621,Genbank:NM_000311.4,HGNC:HGNC:9449,MIM:176640 prion protein hsa04216,hsa05020 Ferroptosis|Prion diseases PROB1 46.7693399464484 43.135075026501 50.4036048663958 1.16850625240432 0.224665453665942 0.604717892155254 1 0.676661 0.660215 0.928639 0.802143 GeneID:389333,Genbank:NM_001161546.1,HGNC:HGNC:41906 proline rich basic protein 1 PROC 0.980142803914724 1.96028560782945 0 0 -Inf 0.468110954943058 1 0 0 0 0 GeneID:5624,Genbank:XM_024453002.1,HGNC:HGNC:9451,MIM:612283 protein C, inactivator of coagulation factors Va and VIIIa hsa04610 Complement and coagulation cascades PROCA1 38.0266636440679 30.018817033238 46.0345102548977 1.53352179747545 0.616848673214801 0.193099119001454 1 0.213275 0.270617 0.369116 0.489416 GeneID:147011,Genbank:XM_006721723.3,HGNC:HGNC:28600,MIM:617376 protein interacting with cyclin A1 GO:0004623,GO:0006644,GO:0030332,GO:0050482 phospholipase A2 activity|phospholipid metabolic process|cyclin binding|arachidonic acid secretion PROCR 637.724668047159 683.271791832145 592.177544262173 0.866679338062956 -0.206429784205564 0.212655858657923 1 17.6203 17.6156 14.9521 16.3125 GeneID:10544,Genbank:NM_006404.4,HGNC:HGNC:9452,MIM:600646 protein C receptor hsa04610 Complement and coagulation cascades PRODH 4.96239811245537 4.11267631439867 5.81211991051207 1.41322084846881 0.498986937783534 0.773553446039055 1 0.0619537 0.0710385 0.0382614 0.124534 GeneID:5625,Genbank:NM_016335.4,HGNC:HGNC:9453,MIM:606810 proline dehydrogenase 1 GO:0004657,GO:0005739,GO:0005743,GO:0005759,GO:0006560,GO:0006562,GO:0008631,GO:0010133,GO:0010942,GO:0019470,GO:0071949 proline dehydrogenase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|proline metabolic process|proline catabolic process|intrinsic apoptotic signaling pathway in response to oxidative stress|proline catabolic process to glutamate|positive regulation of cell death|4-hydroxyproline catabolic process|FAD binding hsa00330 Arginine and proline metabolism PROK1 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0987355 GeneID:84432,Genbank:NM_032414.2,HGNC:HGNC:18454,MIM:606233 prokineticin 1 GO:0000187,GO:0001525,GO:0001664,GO:0005576,GO:0007186,GO:0007623,GO:0008083,GO:0008284,GO:0045765,GO:0051781 activation of MAPK activity|angiogenesis|G-protein coupled receptor binding|extracellular region|G-protein coupled receptor signaling pathway|circadian rhythm|growth factor activity|positive regulation of cell proliferation|regulation of angiogenesis|positive regulation of cell division PROK2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0310361 0 0 GeneID:60675,Genbank:NM_021935.3,HGNC:HGNC:18455,MIM:607002 prokineticin 2 GO:0000187,GO:0001525,GO:0001664,GO:0005576,GO:0005623,GO:0006935,GO:0006954,GO:0007186,GO:0007204,GO:0007218,GO:0007283,GO:0007623,GO:0008283,GO:0008284,GO:0019233,GO:0043066,GO:0045765,GO:0045987 activation of MAPK activity|angiogenesis|G-protein coupled receptor binding|extracellular region|cell|chemotaxis|inflammatory response|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|spermatogenesis|circadian rhythm|cell proliferation|positive regulation of cell proliferation|sensory perception of pain|negative regulation of apoptotic process|regulation of angiogenesis|positive regulation of smooth muscle contraction PROM1 1.24669009255078 2.00831188251439 0.48506830258717 0.241530365283637 -2.04972351828911 0.634396538962021 1 0.0080367 0.00753382 0.00767192 0 GeneID:8842,Genbank:XM_011513902.2,HGNC:HGNC:9454,MIM:604365 prominin 1 hsa05202 Transcriptional misregulation in cancer PROM2 4.48331124776688 4.60274771635603 4.36387477917774 0.948102100767016 -0.0768856640986332 1 1 0.010136 0.026557 0.0565148 0.0176191 GeneID:150696,Genbank:NM_001321070.1,HGNC:HGNC:20685,MIM:617160 prominin 2 GO:0001934,GO:0005887,GO:0005902,GO:0005929,GO:0009986,GO:0015485,GO:0016323,GO:0016324,GO:0031346,GO:0031410,GO:0031528,GO:0042995,GO:0043087,GO:0044393,GO:0048550,GO:0060170,GO:0070062,GO:0071914,GO:2001287 positive regulation of protein phosphorylation|integral component of plasma membrane|microvillus|cilium|cell surface|cholesterol binding|basolateral plasma membrane|apical plasma membrane|positive regulation of cell projection organization|cytoplasmic vesicle|microvillus membrane|cell projection|regulation of GTPase activity|microspike|negative regulation of pinocytosis|ciliary membrane|extracellular exosome|prominosome|negative regulation of caveolin-mediated endocytosis PROS1 443.593791948099 421.433652366277 465.753931529921 1.10516549619328 0.144262426322127 0.404049640025686 1 4.8498 4.33833 5.47353 4.76411 GeneID:5627,Genbank:NM_000313.3,HGNC:HGNC:9456,MIM:176880 protein S hsa04610 Complement and coagulation cascades PROSER1 523.976258144125 503.725396273828 544.227120014422 1.08040437119152 0.111571381949118 0.492776515566753 1 5.05184 4.1504 5.06126 5.03596 GeneID:80209,Genbank:XM_005266545.4,HGNC:HGNC:20291 proline and serine rich 1 PROSER2 96.448945309693 105.661283722341 87.236606897045 0.825625090135071 -0.27644128102611 0.365279278193283 1 1.05299 1.06174 0.944481 0.831517 GeneID:254427,Genbank:XM_011519438.2,HGNC:HGNC:23728 proline and serine rich 2 PROSER3 437.524733443814 442.247990967658 432.801475919969 0.978639778493918 -0.0311501701078532 0.854756421542181 1 3.69032 4.08751 4.47575 3.71227 GeneID:148137,Genbank:NM_001039887.2,HGNC:HGNC:25204 proline and serine rich 3 PROX1 103.530751664269 96.0617694370414 110.999733891496 1.15550374037452 0.208521929828076 0.491722025510539 1 0.391001 0.401553 0.588577 0.37387 GeneID:5629,Genbank:XM_011509773.2,HGNC:HGNC:9459,MIM:601546 prospero homeobox 1 GO:0000122,GO:0001046,GO:0001078,GO:0001709,GO:0001822,GO:0001889,GO:0001938,GO:0001946,GO:0002088,GO:0002194,GO:0003677,GO:0003700,GO:0003705,GO:0003714,GO:0005634,GO:0005737,GO:0006351,GO:0007420,GO:0007623,GO:0008284,GO:0008285,GO:0010468,GO:0010595,GO:0016922,GO:0021516,GO:0021542,GO:0021707,GO:0021915,GO:0030182,GO:0030240,GO:0030324,GO:0030910,GO:0031016,GO:0031667,GO:0042752,GO:0043049,GO:0043433,GO:0044212,GO:0045071,GO:0045737,GO:0045787,GO:0045892,GO:0045893,GO:0045944,GO:0046619,GO:0048845,GO:0050692,GO:0050693,GO:0055005,GO:0055007,GO:0055009,GO:0055010,GO:0060042,GO:0060059,GO:0060214,GO:0060298,GO:0060412,GO:0060414,GO:0060421,GO:0060836,GO:0060849,GO:0061114,GO:0070309,GO:0070365,GO:0070858,GO:0072574,GO:0090425,GO:0097150,GO:1901978,GO:2000179,GO:2000979 negative regulation of transcription from RNA polymerase II promoter|core promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|cell fate determination|kidney development|liver development|positive regulation of endothelial cell proliferation|lymphangiogenesis|lens development in camera-type eye|hepatocyte cell migration|DNA binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|transcription corepressor activity|nucleus|cytoplasm|transcription, DNA-templated|brain development|circadian rhythm|positive regulation of cell proliferation|negative regulation of cell proliferation|regulation of gene expression|positive regulation of endothelial cell migration|ligand-dependent nuclear receptor binding|dorsal spinal cord development|dentate gyrus development|cerebellar granule cell differentiation|neural tube development|neuron differentiation|skeletal muscle thin filament assembly|lung development|olfactory placode formation|pancreas development|response to nutrient levels|regulation of circadian rhythm|otic placode formation|negative regulation of DNA binding transcription factor activity|transcription regulatory region DNA binding|negative regulation of viral genome replication|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of cell cycle|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|optic placode formation involved in camera-type eye formation|venous blood vessel morphogenesis|DBD domain binding|LBD domain binding|ventricular cardiac myofibril assembly|cardiac muscle cell differentiation|atrial cardiac muscle tissue morphogenesis|ventricular cardiac muscle tissue morphogenesis|retina morphogenesis in camera-type eye|embryonic retina morphogenesis in camera-type eye|endocardium formation|positive regulation of sarcomere organization|ventricular septum morphogenesis|aorta smooth muscle tissue morphogenesis|positive regulation of heart growth|lymphatic endothelial cell differentiation|regulation of transcription involved in lymphatic endothelial cell fate commitment|branching involved in pancreas morphogenesis|lens fiber cell morphogenesis|hepatocyte differentiation|negative regulation of bile acid biosynthetic process|hepatocyte proliferation|acinar cell differentiation|neuronal stem cell population maintenance|positive regulation of cell cycle checkpoint|positive regulation of neural precursor cell proliferation|positive regulation of forebrain neuron differentiation PROX2 1.50649433770985 1.07619535328461 1.93679332213509 1.7996670550787 0.847730027434814 0.867084781262262 1 0 0 0 0.0111603 GeneID:283571,Genbank:NM_001080408.2,HGNC:HGNC:26715,MIM:615094 prospero homeobox 2 GO:0000122,GO:0001078,GO:0001946,GO:0003677,GO:0005634,GO:0006351,GO:0030182,GO:0045944,GO:0055007,GO:0060836,GO:0070309 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|lymphangiogenesis|DNA binding|nucleus|transcription, DNA-templated|neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|cardiac muscle cell differentiation|lymphatic endothelial cell differentiation|lens fiber cell morphogenesis PROZ 1.0016543915721 1.51824048055703 0.48506830258717 0.319493722370782 -1.64614051048666 0.791481013618379 1 0.02653 0.0473282 0 0 GeneID:8858,Genbank:XM_017020812.1,HGNC:HGNC:9460,MIM:176895 protein Z, vitamin K dependent plasma glycoprotein PRPF18 225.4042262226 241.436420026435 209.372032418764 0.867193244481674 -0.205574576884172 0.579169348739833 1 0.605107 0.437089 0.503537 0.424916 GeneID:8559,Genbank:XM_017016860.2,HGNC:HGNC:17351,MIM:604993 pre-mRNA processing factor 18 GO:0000350,GO:0005634,GO:0005681,GO:0005682,GO:0006397,GO:0008380,GO:0016607,GO:0046540,GO:0071021,GO:0071048 generation of catalytic spliceosome for second transesterification step|nucleus|spliceosomal complex|U5 snRNP|mRNA processing|RNA splicing|nuclear speck|U4/U6 x U5 tri-snRNP complex|U2-type post-spliceosomal complex|nuclear retention of unspliced pre-mRNA at the site of transcription hsa03040 Spliceosome PRPF19 3444.87852752537 3501.43927800256 3388.31777704819 0.96769285657328 -0.0473788827313432 0.717632803909665 1 54.1352 54.9442 50.8386 55.232 GeneID:27339,Genbank:NM_014502.4,HGNC:HGNC:17896,MIM:608330 pre-mRNA processing factor 19 GO:0000209,GO:0000244,GO:0000245,GO:0000349,GO:0000398,GO:0000974,GO:0001833,GO:0005634,GO:0005654,GO:0005737,GO:0005811,GO:0005819,GO:0006283,GO:0006303,GO:0008610,GO:0010498,GO:0016020,GO:0016607,GO:0034450,GO:0034613,GO:0035861,GO:0042802,GO:0045665,GO:0048026,GO:0048711,GO:0061630,GO:0070534,GO:0071006,GO:0071013,GO:0072422 protein polyubiquitination|spliceosomal tri-snRNP complex assembly|spliceosomal complex assembly|generation of catalytic spliceosome for first transesterification step|mRNA splicing, via spliceosome|Prp19 complex|inner cell mass cell proliferation|nucleus|nucleoplasm|cytoplasm|lipid droplet|spindle|transcription-coupled nucleotide-excision repair|double-strand break repair via nonhomologous end joining|lipid biosynthetic process|proteasomal protein catabolic process|membrane|nuclear speck|ubiquitin-ubiquitin ligase activity|cellular protein localization|site of double-strand break|identical protein binding|negative regulation of neuron differentiation|positive regulation of mRNA splicing, via spliceosome|positive regulation of astrocyte differentiation|ubiquitin protein ligase activity|protein K63-linked ubiquitination|U2-type catalytic step 1 spliceosome|catalytic step 2 spliceosome|signal transduction involved in DNA damage checkpoint hsa03040,hsa04120 Spliceosome|Ubiquitin mediated proteolysis PRPF3 1092.29425599954 1118.96554112987 1065.62297086922 0.952328674744719 -0.0704685217858244 0.650348032425236 1 8.69886 8.49268 7.83977 8.59868 GeneID:9129,Genbank:NM_001350529.1,HGNC:HGNC:17348,MIM:607301 pre-mRNA processing factor 3 GO:0000244,GO:0000375,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005681,GO:0005829,GO:0006397,GO:0008380,GO:0015030,GO:0016607,GO:0042802,GO:0043234,GO:0046540 spliceosomal tri-snRNP complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|spliceosomal complex|cytosol|mRNA processing|RNA splicing|Cajal body|nuclear speck|identical protein binding|protein complex|U4/U6 x U5 tri-snRNP complex hsa03040 Spliceosome PRPF31 2381.81388669931 2408.90714961221 2354.72062378642 0.977505764041374 -0.0328228853273328 0.805739131675415 1 38.6696 38.5052 36.6685 37.9235 GeneID:26121,Genbank:NM_015629.3,HGNC:HGNC:15446,MIM:606419 pre-mRNA processing factor 31 GO:0000244,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005684,GO:0005687,GO:0005690,GO:0015030,GO:0016607,GO:0030621,GO:0030622,GO:0043021,GO:0046540,GO:0070990,GO:0071011,GO:0071166,GO:0071339 spliceosomal tri-snRNP complex assembly|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|U2-type spliceosomal complex|U4 snRNP|U4atac snRNP|Cajal body|nuclear speck|U4 snRNA binding|U4atac snRNA binding|ribonucleoprotein complex binding|U4/U6 x U5 tri-snRNP complex|snRNP binding|precatalytic spliceosome|ribonucleoprotein complex localization|MLL1 complex hsa03040 Spliceosome PRPF38A 890.273462694589 937.757843267797 842.789082121381 0.898727841277788 -0.154043799485907 0.328103493521662 1 9.94682 9.97844 9.29732 8.61964 GeneID:84950,Genbank:NM_032864.3,HGNC:HGNC:25930,MIM:617031 pre-mRNA processing factor 38A GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0031965,GO:0071011 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|nuclear membrane|precatalytic spliceosome hsa03040 Spliceosome PRPF38B 501.865360452617 515.688006673797 488.042714231436 0.94639143806994 -0.0794910731009465 0.806733724837374 1 3.38552 2.67279 3.14891 2.72462 GeneID:55119,Genbank:NM_001349758.1,HGNC:HGNC:25512 pre-mRNA processing factor 38B GO:0003723,GO:0006397,GO:0008380,GO:0071011 RNA binding|mRNA processing|RNA splicing|precatalytic spliceosome hsa03040 Spliceosome PRPF39 182.094829169394 191.623658817017 172.565999521771 0.900546417843711 -0.151127454439287 0.688740038743546 1 2.1355 2.05925 2.41112 1.43721 GeneID:55015,Genbank:NM_017922.3,HGNC:HGNC:20314,MIM:614907 pre-mRNA processing factor 39 GO:0000243,GO:0000395,GO:0005685,GO:0071004 commitment complex|mRNA 5'-splice site recognition|U1 snRNP|U2-type prespliceosome PRPF4 1368.33633475894 1457.79189997687 1278.880769541 0.877272517127642 -0.188903021845015 0.193125960633062 1 16.406 16.8428 14.2571 14.7831 GeneID:9128,Genbank:NM_001322267.1,HGNC:HGNC:17349,MIM:607795 pre-mRNA processing factor 4 GO:0005681,GO:0006397,GO:0008380,GO:0016607,GO:0071001,GO:0097525 spliceosomal complex|mRNA processing|RNA splicing|nuclear speck|U4/U6 snRNP|spliceosomal snRNP complex hsa03040 Spliceosome PRPF40A 722.919938185258 769.674178052384 676.165698318132 0.878509007576595 -0.186871016258192 0.608245834068318 1 2.75591 2.17819 2.59934 1.7111 GeneID:55660,Genbank:NM_001354431.1,HGNC:HGNC:16463,MIM:612941 pre-mRNA processing factor 40 homolog A GO:0000398,GO:0003723,GO:0005654,GO:0005685,GO:0005829,GO:0007010,GO:0007049,GO:0008360,GO:0016020,GO:0016363,GO:0016477,GO:0016607,GO:0032465,GO:0051301,GO:0070064,GO:0071004 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|U1 snRNP|cytosol|cytoskeleton organization|cell cycle|regulation of cell shape|membrane|nuclear matrix|cell migration|nuclear speck|regulation of cytokinesis|cell division|proline-rich region binding|U2-type prespliceosome hsa03040 Spliceosome PRPF40B 163.785806863778 156.013159609256 171.5584541183 1.09964091841982 0.137032496669778 0.609368456251012 1 0.493024 0.658495 0.719707 0.61727 GeneID:25766,Genbank:XM_017019135.2,HGNC:HGNC:25031 pre-mRNA processing factor 40 homolog B GO:0000398,GO:0003723,GO:0005685,GO:0016607,GO:0071004 mRNA splicing, via spliceosome|RNA binding|U1 snRNP|nuclear speck|U2-type prespliceosome hsa03040 Spliceosome PRPF4B 680.717390311521 713.385644413898 648.049136209144 0.908413480539782 -0.138578979591584 0.595935792736366 1 3.14978 2.86747 3.36279 2.24683 GeneID:8899,Genbank:XM_017011432.2,HGNC:HGNC:17346,MIM:602338 pre-mRNA processing factor 4B GO:0000398,GO:0003723,GO:0004672,GO:0004674,GO:0005524,GO:0005694,GO:0006468,GO:0008380,GO:0016607,GO:0071013 mRNA splicing, via spliceosome|RNA binding|protein kinase activity|protein serine/threonine kinase activity|ATP binding|chromosome|protein phosphorylation|RNA splicing|nuclear speck|catalytic step 2 spliceosome PRPF6 3672.02287036253 3539.44229929032 3804.60344143475 1.07491607991394 0.104224031146877 0.442968284285423 1 34.4672 35.0354 36.9285 39.3864 GeneID:24148,Genbank:NM_012469.3,HGNC:HGNC:15860,MIM:613979 pre-mRNA processing factor 6 GO:0000244,GO:0000245,GO:0000375,GO:0000398,GO:0003713,GO:0003723,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0006403,GO:0008380,GO:0016020,GO:0016607,GO:0043021,GO:0045944,GO:0046540,GO:0050681,GO:0071013 spliceosomal tri-snRNP complex assembly|spliceosomal complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|transcription coactivator activity|RNA binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|RNA localization|RNA splicing|membrane|nuclear speck|ribonucleoprotein complex binding|positive regulation of transcription from RNA polymerase II promoter|U4/U6 x U5 tri-snRNP complex|androgen receptor binding|catalytic step 2 spliceosome hsa03040 Spliceosome PRPF8 16298.8004556792 16593.5744729531 16004.0264384052 0.964471305714826 -0.0521897780424555 0.677636203624926 1 63.4492 65.8381 65.5286 60.6238 GeneID:10594,Genbank:NM_006445.3,HGNC:HGNC:17340,MIM:607300 pre-mRNA processing factor 8 GO:0000244,GO:0000375,GO:0000386,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005682,GO:0006397,GO:0008380,GO:0016020,GO:0016607,GO:0017070,GO:0030619,GO:0030620,GO:0030623,GO:0046540,GO:0070530,GO:0071013,GO:0071222,GO:0071356,GO:0097157 spliceosomal tri-snRNP complex assembly|RNA splicing, via transesterification reactions|second spliceosomal transesterification activity|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|U5 snRNP|mRNA processing|RNA splicing|membrane|nuclear speck|U6 snRNA binding|U1 snRNA binding|U2 snRNA binding|U5 snRNA binding|U4/U6 x U5 tri-snRNP complex|K63-linked polyubiquitin modification-dependent protein binding|catalytic step 2 spliceosome|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|pre-mRNA intronic binding hsa03040 Spliceosome PRPH 7.44696869042154 6.65908587355536 8.23485150728773 1.23663392598526 0.306418490348114 0.834916278877812 1 0.130473 0.138759 0.0299177 0.30739 GeneID:5630,Genbank:NM_006262.3,HGNC:HGNC:9461,MIM:170710 peripherin hsa05014 Amyotrophic lateral sclerosis (ALS) PRPS1 2818.65008305287 2796.40141372959 2840.89875237615 1.01591235737047 0.0227759463611762 0.869927503886966 1 57.1975 58.354 61.0309 58.1471 GeneID:5631,Genbank:NM_002764.3,HGNC:HGNC:9462,MIM:311850 phosphoribosyl pyrophosphate synthetase 1 GO:0000287,GO:0002189,GO:0004749,GO:0005524,GO:0006015,GO:0006144,GO:0006164,GO:0006167,GO:0007399,GO:0009116,GO:0009165,GO:0016208,GO:0016301,GO:0019003,GO:0019693,GO:0030246,GO:0031100,GO:0034418,GO:0042802,GO:0042803,GO:0043234,GO:0043531,GO:0046101 magnesium ion binding|ribose phosphate diphosphokinase complex|ribose phosphate diphosphokinase activity|ATP binding|5-phosphoribose 1-diphosphate biosynthetic process|purine nucleobase metabolic process|purine nucleotide biosynthetic process|AMP biosynthetic process|nervous system development|nucleoside metabolic process|nucleotide biosynthetic process|AMP binding|kinase activity|GDP binding|ribose phosphate metabolic process|carbohydrate binding|animal organ regeneration|urate biosynthetic process|identical protein binding|protein homodimerization activity|protein complex|ADP binding|hypoxanthine biosynthetic process hsa00030,hsa00230 Pentose phosphate pathway|Purine metabolism PRPS2 1335.13460491496 1384.96336618397 1285.30584364595 0.928043206794265 -0.107736120594049 0.472586812543251 1 22.1186 21.1509 22.5175 18.824 GeneID:5634,Genbank:NM_001039091.2,HGNC:HGNC:9465,MIM:311860 phosphoribosyl pyrophosphate synthetase 2 GO:0000287,GO:0002189,GO:0004749,GO:0005524,GO:0006015,GO:0006139,GO:0006167,GO:0009116,GO:0016208,GO:0016301,GO:0019003,GO:0030246,GO:0031100,GO:0042802,GO:0042803,GO:0043234,GO:0043531,GO:0070062 magnesium ion binding|ribose phosphate diphosphokinase complex|ribose phosphate diphosphokinase activity|ATP binding|5-phosphoribose 1-diphosphate biosynthetic process|nucleobase-containing compound metabolic process|AMP biosynthetic process|nucleoside metabolic process|AMP binding|kinase activity|GDP binding|carbohydrate binding|animal organ regeneration|identical protein binding|protein homodimerization activity|protein complex|ADP binding|extracellular exosome hsa00030,hsa00230 Pentose phosphate pathway|Purine metabolism PRPSAP1 977.883493350451 947.713158786107 1008.0538279148 1.06366975974669 0.0890503031621827 0.561257744242417 1 16.4484 16.4511 18.6742 16.576 GeneID:5635,Genbank:NM_001330503.1,HGNC:HGNC:9466,MIM:601249 phosphoribosyl pyrophosphate synthetase associated protein 1 GO:0000287,GO:0004749,GO:0004857,GO:0006139,GO:0009165,GO:0042802 magnesium ion binding|ribose phosphate diphosphokinase activity|enzyme inhibitor activity|nucleobase-containing compound metabolic process|nucleotide biosynthetic process|identical protein binding PRPSAP2 642.047499454136 659.431797925612 624.663200982659 0.947274915992335 -0.0781449127204585 0.637236370644761 1 8.64629 8.14166 7.81004 8.10078 GeneID:5636,Genbank:NM_001353106.1,HGNC:HGNC:9467,MIM:603762 phosphoribosyl pyrophosphate synthetase associated protein 2 GO:0000287,GO:0004749,GO:0004857,GO:0006139,GO:0009116,GO:0009165,GO:0060348 magnesium ion binding|ribose phosphate diphosphokinase activity|enzyme inhibitor activity|nucleobase-containing compound metabolic process|nucleoside metabolic process|nucleotide biosynthetic process|bone development PRR11 3925.86994190198 4016.87429364527 3834.86559015869 0.954688972026205 -0.0668973005886127 0.634697149542033 1 20.9313 20.0367 19.8413 19.1997 GeneID:55771,Genbank:XM_024450828.1,HGNC:HGNC:25619,MIM:615920 proline rich 11 GO:0005634,GO:0005737,GO:0007050,GO:0016020,GO:0051726 nucleus|cytoplasm|cell cycle arrest|membrane|regulation of cell cycle PRR12 1050.55547611838 1027.17135248725 1073.93959974952 1.0455311055444 0.0642359841150496 0.686724534952193 1 5.87726 5.86018 6.45384 6.16659 GeneID:57479,Genbank:NM_020719.2,HGNC:HGNC:29217,MIM:616633 proline rich 12 GO:0003677,GO:0005634,GO:0014069,GO:0030054,GO:0043005,GO:0045211 DNA binding|nucleus|postsynaptic density|cell junction|neuron projection|postsynaptic membrane PRR13 1740.51974242659 1779.03250628235 1702.00697857083 0.95670369853304 -0.0638559192320783 0.649247878179159 1 58.2089 59.1602 56.7958 54.5123 GeneID:54458,Genbank:NM_018457.3,HGNC:HGNC:24528,MIM:610459 proline rich 13 GO:0005654,GO:0005829,GO:0006351,GO:0006355 nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated PRR14 632.093951427473 639.513392235594 624.674510619353 0.976796605362137 -0.0338699083168788 0.807578891920389 1 8.16016 9.54472 8.66509 8.84204 GeneID:78994,Genbank:NM_001320464.1,HGNC:HGNC:28458,MIM:617423 proline rich 14 GO:0005652,GO:0005654,GO:0005694,GO:0007517 nuclear lamina|nucleoplasm|chromosome|muscle organ development PRR14L 309.252592660121 294.210243958667 324.294941361574 1.10225577803856 0.140459039598907 0.725068049110068 1 0.751159 0.758715 1.09707 0.600728 GeneID:253143,Genbank:NM_173566.2,HGNC:HGNC:28738 proline rich 14 like PRR15 99.4953343229345 85.5977822074129 113.392886438456 1.32471757461768 0.405684814672592 0.186371621113812 1 1.02628 1.47273 1.62672 1.7331 GeneID:222171,Genbank:NM_175887.2,HGNC:HGNC:22310 proline rich 15 GO:0007275 multicellular organism development PRR15L 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0243475 0 0 0 GeneID:79170,Genbank:XM_005257666.4,HGNC:HGNC:28149 proline rich 15 like PRR16 171.834216505154 172.578517725581 171.089915284727 0.991374346816324 -0.0124981673275663 0.992817978422955 1 1.49889 1.38256 1.69419 1.31937 GeneID:51334,Genbank:NM_016644.2,HGNC:HGNC:29654,MIM:615931 proline rich 16 GO:0045727,GO:0045793 positive regulation of translation|positive regulation of cell size PRR18 2.93888269973389 1.51824048055703 4.35952491891075 2.87143240793532 1.52177060181302 0.472583741512024 1 0 0.0224344 0.0478053 0.134588 GeneID:285800,Genbank:NM_175922.3,HGNC:HGNC:28574 proline rich 18 PRR19 114.874029604544 109.572046282892 120.176012926196 1.09677620344816 0.133269174680023 0.635539977881035 1 1.28793 1.13973 1.3547 1.49556 GeneID:284338,Genbank:NM_199285.2,HGNC:HGNC:33728 proline rich 19 PRR22 56.5579969823863 52.5424842130608 60.5735097517119 1.15284822670518 0.205202593655391 0.621477550804959 1 1.12082 1.73985 1.54478 1.9544 GeneID:163154,Genbank:NM_001134316.1,HGNC:HGNC:28354 proline rich 22 PRR29 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0.0132456 0.0230339 0 0 GeneID:92340,Genbank:NM_001164257.1,HGNC:HGNC:25673 proline rich 29 PRR3 442.793094845933 505.14860120587 380.437588485997 0.753120146384316 -0.40904805633022 0.0226325025200613 0.612664613324667 4.70428 4.93243 3.92838 3.55619 GeneID:80742,Genbank:NM_025263.3,HGNC:HGNC:21149 proline rich 3 GO:0046872 metal ion binding PRR34 21.305693142026 26.1364634371561 16.4749228468958 0.630342467201387 -0.665792232160073 0.421685707600621 1 0.241864 0.0642634 0.022506 0.0844882 GeneID:55267,Genbank:NM_018280.2,HGNC:HGNC:25606 proline rich 34 PRR36 102.533482268729 100.386168160396 104.680796377062 1.04278107527527 0.0604363057323091 0.880219902930156 1 1.00518 1.16885 1.30877 1.20614 GeneID:80164,Genbank:NM_001190467.1,HGNC:HGNC:26172 proline rich 36 PRR4 29.4662669423851 33.2474030930919 25.6851307916783 0.772545474296461 -0.372308238101952 0.485282965488012 1 1.93284 1.97814 1.51862 1.42939 GeneID:11272,Genbank:NM_001098538.2,HGNC:HGNC:18020,MIM:605359 proline rich 4 GO:0001895,GO:0005615,GO:0007601 retina homeostasis|extracellular space|visual perception PRR5 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0212095 0.0541343 0 0.0182294 GeneID:55615,Genbank:NM_001017528.2,HGNC:HGNC:31682,MIM:609406 proline rich 5 GO:0005829,GO:0007049,GO:0014068,GO:0031932,GO:0032148,GO:0038203 cytosol|cell cycle|positive regulation of phosphatidylinositol 3-kinase signaling|TORC2 complex|activation of protein kinase B activity|TORC2 signaling hsa04150 mTOR signaling pathway PRR5L 652.971286940887 629.856043020502 676.086530861273 1.07339849851892 0.102185775168064 0.562433362580008 1 5.60598 6.7909 7.15776 6.23679 GeneID:79899,Genbank:NM_001160167.1,HGNC:HGNC:25878,MIM:611728 proline rich 5 like GO:0001933,GO:0001934,GO:0005739,GO:0009968,GO:0010762,GO:0014068,GO:0031625,GO:0031932,GO:0034599,GO:0038203,GO:0061014,GO:0090316 negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|mitochondrion|negative regulation of signal transduction|regulation of fibroblast migration|positive regulation of phosphatidylinositol 3-kinase signaling|ubiquitin protein ligase binding|TORC2 complex|cellular response to oxidative stress|TORC2 signaling|positive regulation of mRNA catabolic process|positive regulation of intracellular protein transport PRR7 508.274362467858 506.734485271328 509.814239664388 1.0060776491093 0.00874165669592126 0.980727641091773 1 2.29974 2.37033 2.304 2.38188 GeneID:80758,Genbank:XM_011534663.2,HGNC:HGNC:28130 proline rich 7, synaptic GO:0002250,GO:0005634,GO:0016021,GO:0030054,GO:0030425,GO:0045211,GO:0048471 adaptive immune response|nucleus|integral component of membrane|cell junction|dendrite|postsynaptic membrane|perinuclear region of cytoplasm PRRC1 1517.88672575447 1537.71749676719 1498.05595474175 0.974207523742939 -0.0376989698236462 0.821782752235117 1 14.6027 13.3465 14.8532 12.747 GeneID:133619,Genbank:NM_130809.4,HGNC:HGNC:28164 proline rich coiled-coil 1 GO:0005794 Golgi apparatus PRRC2A 13102.9452513491 13015.8656970414 13190.0248056568 1.0133805244053 0.0191760078887453 0.904162474250262 1 59.4967 62.5178 66.5691 60.1674 GeneID:7916,Genbank:NM_004638.3,HGNC:HGNC:13918,MIM:142580 proline rich coiled-coil 2A GO:0003723,GO:0005654,GO:0005829,GO:0005886,GO:0016020,GO:0030154,GO:0070062 RNA binding|nucleoplasm|cytosol|plasma membrane|membrane|cell differentiation|extracellular exosome PRRC2B 5444.28873569349 5436.76634388974 5451.81112749724 1.00276723012465 0.00398675558331279 0.999148268303495 1 16.8265 18.1525 19.1934 16.7707 GeneID:84726,Genbank:NM_013318.3,HGNC:HGNC:28121 proline rich coiled-coil 2B GO:0003723,GO:0030154 RNA binding|cell differentiation PRRC2C 2536.10419885704 2651.43633129958 2420.7720664145 0.913004034016526 -0.1313068602608 0.705508832358689 1 6.76652 6.18419 7.69266 4.34058 GeneID:23215,Genbank:XM_005245020.2,HGNC:HGNC:24903,MIM:617373 proline rich coiled-coil 2C GO:0002244,GO:0003723,GO:0005829,GO:0008022,GO:0016020 hematopoietic progenitor cell differentiation|RNA binding|cytosol|protein C-terminus binding|membrane PRRG1 126.574304120592 124.706424813777 128.442183427406 1.0299564246125 0.0425833011703442 0.888503436478874 1 0.792212 0.789869 0.973356 0.64064 GeneID:5638,Genbank:NM_000950.2,HGNC:HGNC:9469,MIM:300935 proline rich and Gla domain 1 GO:0005509,GO:0005576,GO:0005887 calcium ion binding|extracellular region|integral component of plasma membrane PRRG2 6.71947460301588 6.169014471598 7.26993473443377 1.17845966611108 0.236902381840253 0.8999296622988 1 0.029239 0.126129 0.161772 0.152312 GeneID:5639,Genbank:XM_006723286.2,HGNC:HGNC:9470,MIM:604429 proline rich and Gla domain 2 GO:0004252,GO:0005509,GO:0005576,GO:0005887 serine-type endopeptidase activity|calcium ion binding|extracellular region|integral component of plasma membrane PRRG4 183.364285974313 178.161408245852 188.567163702773 1.05840633815917 0.0818936061882466 0.840198918792893 1 1.41231 1.26066 1.89814 1.07019 GeneID:79056,Genbank:XM_006718313.3,HGNC:HGNC:30799,MIM:611690 proline rich and Gla domain 4 GO:0005509,GO:0005576,GO:0016021 calcium ion binding|extracellular region|integral component of membrane PRRT1 52.2104124384193 50.1401534779589 54.2806713988796 1.08257888406227 0.114472153357553 0.802485994663906 1 0.696208 0.788963 0.883995 0.832445 GeneID:80863,Genbank:XM_024446560.1,HGNC:HGNC:13943 proline rich transmembrane protein 1 GO:0005886,GO:0009607,GO:0016020,GO:0016021,GO:0030054,GO:0045202 plasma membrane|response to biotic stimulus|membrane|integral component of membrane|cell junction|synapse PRRT1B 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.012184 0 0 GeneID:642515,Genbank:XM_017015412.2,HGNC:HGNC:53642 proline rich transmembrane protein 1B PRRT2 56.4526662242155 46.9978113123671 65.9075211360639 1.40235298827035 0.487849537885744 0.196670175657327 1 0.696445 0.495072 0.827067 0.87131 GeneID:112476,Genbank:NM_001256443.1,HGNC:HGNC:30500,MIM:614386 proline rich transmembrane protein 2 PRRT3 299.692258469116 233.942287173875 365.442229764358 1.56210420176301 0.643490693142266 0.00132586915425216 0.121343544997158 2.20013 2.11236 4.04606 3.15934 GeneID:285368,Genbank:NM_207351.4,HGNC:HGNC:26591 proline rich transmembrane protein 3 GO:0016021 integral component of membrane PRRT4 1.51236740913344 2.05633815719933 0.968396661067546 0.470932593298016 -1.08640751970762 0.811664485952849 1 0.0138658 0.0117808 0 0.0238511 GeneID:401399,Genbank:XM_006715985.3,HGNC:HGNC:37280 proline rich transmembrane protein 4 GO:0016021 integral component of membrane PRRX1 847.144469940495 859.67381122316 834.615128657831 0.970850941091627 -0.0426782853969363 0.841496307156946 1 8.40227 7.57283 8.80871 6.80686 GeneID:5396,Genbank:XM_006711388.3,HGNC:HGNC:9142,MIM:167420 paired related homeobox 1 GO:0000978,GO:0001078,GO:0001105,GO:0002053,GO:0003713,GO:0005654,GO:0005829,GO:0030326,GO:0042472,GO:0042474,GO:0045880,GO:0048664,GO:0048701,GO:0048844,GO:0051216,GO:0060021,GO:0070570,GO:0071837,GO:0097150 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription coactivator activity|positive regulation of mesenchymal cell proliferation|transcription coactivator activity|nucleoplasm|cytosol|embryonic limb morphogenesis|inner ear morphogenesis|middle ear morphogenesis|positive regulation of smoothened signaling pathway|neuron fate determination|embryonic cranial skeleton morphogenesis|artery morphogenesis|cartilage development|palate development|regulation of neuron projection regeneration|HMG box domain binding|neuronal stem cell population maintenance PRSS12 1106.84279785956 999.658693391877 1214.02690232724 1.21444139920196 0.280292876865148 0.0585044997617952 0.878658544068731 7.14345 6.37853 8.79897 7.87305 GeneID:8492,Genbank:NM_003619.3,HGNC:HGNC:9477,MIM:606709 serine protease 12 GO:0004252,GO:0005044,GO:0005886,GO:0006887,GO:0008236,GO:0030424,GO:0030425,GO:0031410,GO:0031638,GO:0043083,GO:0043195 serine-type endopeptidase activity|scavenger receptor activity|plasma membrane|exocytosis|serine-type peptidase activity|axon|dendrite|cytoplasmic vesicle|zymogen activation|synaptic cleft|terminal bouton PRSS23 5403.03043841537 5059.61531213812 5746.44556469261 1.13574752430422 0.183642160619914 0.166578943942883 1 55.0573 57.8766 68.865 60.6534 GeneID:11098,Genbank:NM_001293180.1,HGNC:HGNC:14370 serine protease 23 GO:0004252,GO:0005634,GO:0005788,GO:0043687,GO:0044267,GO:0070062 serine-type endopeptidase activity|nucleus|endoplasmic reticulum lumen|post-translational protein modification|cellular protein metabolic process|extracellular exosome PRSS27 19.0821329954828 21.6876031999629 16.4766627910026 0.759727233991022 -0.396446556334734 0.575181836126914 1 0.431252 0.341319 0.424721 0.184922 GeneID:83886,Genbank:NM_001318395.1,HGNC:HGNC:15475,MIM:608018 serine protease 27 GO:0004252,GO:0005576,GO:0008236,GO:0019897,GO:0046658 serine-type endopeptidase activity|extracellular region|serine-type peptidase activity|extrinsic component of plasma membrane|anchored component of plasma membrane PRSS3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:5646,Genbank:NM_001197097.2,HGNC:HGNC:9486,MIM:613578 serine protease 3 GO:0004252,GO:0005509,GO:0005576,GO:0005615,GO:0006508,GO:0007586,GO:0008236,GO:0009235,GO:0019730,GO:0031638,GO:0043312,GO:0043542,GO:0070062,GO:1904724 serine-type endopeptidase activity|calcium ion binding|extracellular region|extracellular space|proteolysis|digestion|serine-type peptidase activity|cobalamin metabolic process|antimicrobial humoral response|zymogen activation|neutrophil degranulation|endothelial cell migration|extracellular exosome|tertiary granule lumen hsa04080,hsa04972,hsa04974,hsa05164 Neuroactive ligand-receptor interaction|Pancreatic secretion|Protein digestion and absorption|Influenza A PRSS33 14.541125488501 14.0581831776007 15.0240677994013 1.06870621968702 0.0958653201771175 0.983055588184268 1 0.11504 0.418411 0.342958 0.17346 GeneID:260429,Genbank:XM_011522451.2,HGNC:HGNC:30405,MIM:613797 serine protease 33 GO:0004252,GO:0005615,GO:0005737,GO:0006508,GO:1904627 serine-type endopeptidase activity|extracellular space|cytoplasm|proteolysis|response to phorbol 13-acetate 12-myristate PRSS35 1755.60001974913 1956.37543385685 1554.82460564141 0.794747561604878 -0.331431409904668 0.0208789050791009 0.591852289817486 28.0128 27.2021 24.752 19.573 GeneID:167681,Genbank:NM_001170423.1,HGNC:HGNC:21387 serine protease 35 GO:0005576,GO:0005739 extracellular region|mitochondrion PRSS36 2.50608216562355 2.10436443188427 2.90779989936283 1.3817948333023 0.466543422563713 0.90757529661644 1 0.0351501 0 0.0321037 0.0300854 GeneID:146547,Genbank:NM_001258290.1,HGNC:HGNC:26906,MIM:610560 serine protease 36 GO:0004252,GO:0005578,GO:0005737 serine-type endopeptidase activity|proteinaceous extracellular matrix|cytoplasm PRSS38 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:339501,Genbank:XM_011544176.3,HGNC:HGNC:29625 serine protease 38 GO:0004252,GO:0005576 serine-type endopeptidase activity|extracellular region PRSS43 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0301092 0 0 0 GeneID:100288960,Genbank:XM_017007617.1,HGNC:HGNC:37323 serine protease 43 GO:0004252,GO:0005576 serine-type endopeptidase activity|extracellular region PRSS45 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:377047,Genbank:NM_199183.2,HGNC:HGNC:30717 serine protease 45 GO:0004252 serine-type endopeptidase activity PRSS53 36.6049331997611 30.5569147098803 42.6529516896419 1.3958526930682 0.481146699288712 0.324113674082524 1 0.21029 0.231 0.493493 0.219015 GeneID:339105,Genbank:NM_001039503.2,HGNC:HGNC:34407,MIM:610561 serine protease 53 GO:0004252,GO:0005576,GO:0005737 serine-type endopeptidase activity|extracellular region|cytoplasm PRSS54 3.2407542825329 3.57457863775636 2.90692992730943 0.81322310176788 -0.29827689552794 0.956860256426559 1 0.0634972 0.0387396 0.0400211 0.0746406 GeneID:221191,Genbank:NM_001305173.1,HGNC:HGNC:26336 serine protease 54 GO:0004252,GO:0005576 serine-type endopeptidase activity|extracellular region PRSS55 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0201784 0 GeneID:203074,Genbank:XM_011543814.3,HGNC:HGNC:30824,MIM:615144 serine protease 55 GO:0004252,GO:0005829,GO:0016021 serine-type endopeptidase activity|cytosol|integral component of membrane PRSS56 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0588991 GeneID:646960,Genbank:NM_001195129.1,HGNC:HGNC:39433,MIM:613858 serine protease 56 GO:0004252,GO:0005783,GO:0006508,GO:0043010 serine-type endopeptidase activity|endoplasmic reticulum|proteolysis|camera-type eye development PRSS57 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0449411 0 0 GeneID:400668,Genbank:NM_001308209.1,HGNC:HGNC:31397 serine protease 57 GO:0004252,GO:0005615,GO:0006508,GO:0008201,GO:0008236,GO:0035578 serine-type endopeptidase activity|extracellular space|proteolysis|heparin binding|serine-type peptidase activity|azurophil granule lumen PRSS8 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0248531 0 0 GeneID:5652,Genbank:NM_002773.4,HGNC:HGNC:9491,MIM:600823 serine protease 8 PRTFDC1 214.157130261534 197.158523062603 231.155737460464 1.1724359356611 0.22950909303563 0.294465020148395 1 4.15065 3.85897 4.27615 4.79959 GeneID:56952,Genbank:NM_001282786.1,HGNC:HGNC:23333,MIM:610751 phosphoribosyl transferase domain containing 1 GO:0000166,GO:0000287,GO:0005737,GO:0006166,GO:0042803 nucleotide binding|magnesium ion binding|cytoplasm|purine ribonucleoside salvage|protein homodimerization activity PRTG 39.1646379253112 48.2759204194994 30.053355431123 0.622533038624034 -0.68377769000509 0.135229103700973 1 0.128738 0.118442 0.0965325 0.0521842 GeneID:283659,Genbank:NM_173814.5,HGNC:HGNC:26373,MIM:613261 protogenin GO:0005615,GO:0007275,GO:0016021 extracellular space|multicellular organism development|integral component of membrane PRTN3 8.94595837907611 6.26506702096788 11.6268497371843 1.85582208430838 0.892058407453994 0.3659155625892 1 0.169298 0.0944692 0.102941 0.628092 GeneID:5657,Genbank:XM_011528136.1,HGNC:HGNC:9495,MIM:177020 proteinase 3 PRUNE1 473.704456067604 516.102659837456 431.306252297752 0.83569856515289 -0.258945436049594 0.14569047718891 1 6.38632 6.15749 5.15431 5.35265 GeneID:58497,Genbank:NM_021222.2,HGNC:HGNC:13420,MIM:617413 prune exopolyphosphatase 1 GO:0004427,GO:0005634,GO:0005829,GO:0005925,GO:0015631,GO:0016791,GO:0031113,GO:0046872,GO:0050767 inorganic diphosphatase activity|nucleus|cytosol|focal adhesion|tubulin binding|phosphatase activity|regulation of microtubule polymerization|metal ion binding|regulation of neurogenesis hsa00230 Purine metabolism PRUNE2 243.036829499727 187.962836284999 298.110822714454 1.58600938678348 0.665401309645861 0.107780575577425 1 0.362232 0.363273 0.769385 0.431685 GeneID:158471,Genbank:XM_017014349.1,HGNC:HGNC:25209,MIM:610691 prune homolog 2 GO:0005737,GO:0006915,GO:0016462,GO:0046872 cytoplasm|apoptotic process|pyrophosphatase activity|metal ion binding PRX 142.909740277756 130.741169116428 155.078311439084 1.18614750416514 0.246283428345422 0.356715974502271 1 0.749451 0.826095 0.902618 0.948464 GeneID:57716,Genbank:XM_011527171.2,HGNC:HGNC:13797,MIM:605725 periaxin PSAP 65230.1544704376 63639.9762793538 66820.3326615213 1.04997419182256 0.0703538671416838 0.621653837422446 1 821.004 866.801 855.147 943.768 GeneID:5660,Genbank:NM_002778.3,HGNC:HGNC:9498,MIM:176801 prosaposin hsa04142 Lysosome PSAT1 3472.27854425797 3575.2831212164 3369.27396729954 0.942379625072387 -0.0856197474897784 0.628253106965035 1 75.3668 77.9521 65.5962 79.6714 GeneID:29968,Genbank:NM_058179.3,HGNC:HGNC:19129,MIM:610936 phosphoserine aminotransferase 1 GO:0004648,GO:0005737,GO:0005829,GO:0006564,GO:0008615,GO:0070062 O-phospho-L-serine:2-oxoglutarate aminotransferase activity|cytoplasm|cytosol|L-serine biosynthetic process|pyridoxine biosynthetic process|extracellular exosome hsa00260,hsa00750 Glycine, serine and threonine metabolism|Vitamin B6 metabolism PSCA 1.80542938479706 2.64246210852658 0.968396661067546 0.366475136178024 -1.44821277409849 0.669336513612722 1 0.123093 0 0 0.0528502 GeneID:8000,Genbank:NM_005672.4,HGNC:HGNC:9500,MIM:602470 prostate stem cell antigen PSD 17.8546807886396 18.2669120413693 17.44244953591 0.954865797591179 -0.0666301122675679 0.947218156773886 1 0.112645 0.182367 0.1139 0.184808 GeneID:5662,Genbank:NM_001270965.1,HGNC:HGNC:9507,MIM:602327 pleckstrin and Sec7 domain containing GO:0004871,GO:0005086,GO:0005543,GO:0007165,GO:0014069,GO:0031175,GO:0032012,GO:0032154,GO:0032587,GO:0043197,GO:0098999 signal transducer activity|ARF guanyl-nucleotide exchange factor activity|phospholipid binding|signal transduction|postsynaptic density|neuron projection development|regulation of ARF protein signal transduction|cleavage furrow|ruffle membrane|dendritic spine|extrinsic component of postsynaptic endosome membrane hsa04144 Endocytosis PSD2 5.9379728030266 5.09281911831339 6.78312648773981 1.33190013824528 0.413485917650062 0.802150810112119 1 0.0220309 0.0196071 0.0258469 0.0385618 GeneID:84249,Genbank:XM_011537696.2,HGNC:HGNC:19092 pleckstrin and Sec7 domain containing 2 GO:0005086,GO:0005543,GO:0016021,GO:0030425,GO:0032012,GO:0032154,GO:0032587,GO:0043025 ARF guanyl-nucleotide exchange factor activity|phospholipid binding|integral component of membrane|dendrite|regulation of ARF protein signal transduction|cleavage furrow|ruffle membrane|neuronal cell body hsa04144 Endocytosis PSD3 414.822198966309 402.600233683797 427.044164248821 1.06071514251585 0.0850372692052995 0.792617145889423 1 0.705973 0.679047 0.935902 0.561808 GeneID:23362,Genbank:NM_015310.3,HGNC:HGNC:19093,MIM:614440 pleckstrin and Sec7 domain containing 3 GO:0005086,GO:0014069,GO:0030054,GO:0032012,GO:0032587,GO:0045211 ARF guanyl-nucleotide exchange factor activity|postsynaptic density|cell junction|regulation of ARF protein signal transduction|ruffle membrane|postsynaptic membrane hsa04144 Endocytosis PSD4 1357.7392746645 1216.57599401365 1498.90255531535 1.23206652333346 0.301080153997341 0.0420038157530741 0.765339150285819 7.51561 7.98207 9.76435 10.0017 GeneID:23550,Genbank:XM_005263634.2,HGNC:HGNC:19096,MIM:614442 pleckstrin and Sec7 domain containing 4 hsa04144 Endocytosis PSEN1 1181.61209664523 1193.32110705759 1169.90308623287 0.980375759142936 -0.0285932824458007 0.848359789648045 1 7.06671 7.32284 7.31781 6.85932 GeneID:5663,Genbank:NM_000021.3,HGNC:HGNC:9508,MIM:104311 presenilin 1 GO:0000139,GO:0005739,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0006509,GO:0006915,GO:0007155,GO:0007219,GO:0016021,GO:0016235,GO:0016485,GO:0034205,GO:0035556,GO:0042500,GO:0042982,GO:0043085,GO:0060828,GO:0070765 Golgi membrane|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|membrane protein ectodomain proteolysis|apoptotic process|cell adhesion|Notch signaling pathway|integral component of membrane|aggresome|protein processing|amyloid-beta formation|intracellular signal transduction|aspartic endopeptidase activity, intramembrane cleaving|amyloid precursor protein metabolic process|positive regulation of catalytic activity|regulation of canonical Wnt signaling pathway|gamma-secretase complex hsa04310,hsa04330,hsa04722,hsa05010,hsa05165 Wnt signaling pathway|Notch signaling pathway|Neurotrophin signaling pathway|Alzheimer disease|Human papillomavirus infection PSEN2 390.014159391597 385.074350073772 394.953968709423 1.02565639241813 0.036547491196988 0.878090119740132 1 5.56317 6.40992 6.0451 6.22772 GeneID:5664,Genbank:NM_000447.2,HGNC:HGNC:9509,MIM:600759 presenilin 2 hsa04330,hsa04722,hsa05010 Notch signaling pathway|Neurotrophin signaling pathway|Alzheimer disease PSENEN 1182.14869935213 1184.27051610489 1180.02688259936 0.996416668786542 -0.00517893864930424 0.954107760664326 1 43.2225 50.327 46.0035 47.9652 GeneID:55851,Genbank:NM_172341.3,HGNC:HGNC:30100,MIM:607632 presenilin enhancer gamma-secretase subunit GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005887,GO:0006509,GO:0007219,GO:0007220,GO:0016021,GO:0016485,GO:0031293,GO:0032580,GO:0034205,GO:0035333,GO:0042982,GO:0042987,GO:0043065,GO:0043085,GO:0048013,GO:0070765 endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|integral component of plasma membrane|membrane protein ectodomain proteolysis|Notch signaling pathway|Notch receptor processing|integral component of membrane|protein processing|membrane protein intracellular domain proteolysis|Golgi cisterna membrane|amyloid-beta formation|Notch receptor processing, ligand-dependent|amyloid precursor protein metabolic process|amyloid precursor protein catabolic process|positive regulation of apoptotic process|positive regulation of catalytic activity|ephrin receptor signaling pathway|gamma-secretase complex hsa04330,hsa05010 Notch signaling pathway|Alzheimer disease PSG1 2.34102551175427 3.22858605985383 1.45346496365472 0.450186222919057 -1.1514061883185 0.744020357963777 1 0.042691 0 0.0101553 0.0189856 GeneID:5669,Genbank:NM_001330524.1,HGNC:HGNC:9514,MIM:176390 pregnancy specific beta-1-glycoprotein 1 GO:0005576,GO:0007565,GO:0050900 extracellular region|female pregnancy|leukocyte migration PSG4 4.28999996276324 5.18887166768327 3.3911282578432 0.653538664092125 -0.613655504859129 0.749853956654003 1 0.0671553 0.0420953 0.0212875 0.0397579 GeneID:5672,Genbank:NM_001316339.1,HGNC:HGNC:9521,MIM:176393 pregnancy specific beta-1-glycoprotein 4 GO:0007565,GO:0070062 female pregnancy|extracellular exosome PSG5 14.070838636289 17.4788743361943 10.6628029363838 0.610039452844157 -0.713025546339636 0.365605853493231 1 0.238171 0.140358 0.113344 0.119089 GeneID:5673,Genbank:NM_001130014.1,HGNC:HGNC:9522,MIM:176394 pregnancy specific beta-1-glycoprotein 5 GO:0005576,GO:0007565 extracellular region|female pregnancy PSG7 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0147564 0 GeneID:5676,Genbank:NM_001206650.1,HGNC:HGNC:9524,MIM:176396 pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) GO:0005576,GO:0007565 extracellular region|female pregnancy PSG9 9.57621623170169 10.9158410120089 8.23659145139452 0.754553995641123 -0.406303951648473 0.723099035913752 1 0.100028 0.0599318 0.0433444 0.0811598 GeneID:5678,Genbank:NM_001301709.1,HGNC:HGNC:9526,MIM:176398 pregnancy specific beta-1-glycoprotein 9 GO:0005576,GO:0007565 extracellular region|female pregnancy PSIP1 1689.77178371315 1792.25157447753 1587.29199294878 0.885641288060524 -0.175205613630953 0.286979340142975 1 10.7116 9.51543 10.0065 7.83324 GeneID:11168,Genbank:NM_001128217.2,HGNC:HGNC:9527,MIM:603620 PC4 and SFRS1 interacting protein 1 PSKH1 1227.15454108322 1068.3265245957 1385.98255757073 1.2973398353984 0.375556439978689 0.0115709854206219 0.436049182345131 13.5026 13.108 17.2881 18.1251 GeneID:5681,Genbank:NM_006742.2,HGNC:HGNC:9529,MIM:177015 protein serine kinase H1 GO:0004674,GO:0005524,GO:0005622,GO:0005654,GO:0005789,GO:0005794,GO:0005815,GO:0005886,GO:0007368,GO:0007507,GO:0016607,GO:0018105,GO:0018107,GO:0035556 protein serine/threonine kinase activity|ATP binding|intracellular|nucleoplasm|endoplasmic reticulum membrane|Golgi apparatus|microtubule organizing center|plasma membrane|determination of left/right symmetry|heart development|nuclear speck|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|intracellular signal transduction PSMA1 2498.0580076102 2765.52589840542 2230.59011681498 0.806569961286973 -0.31012841776903 0.025711269273232 0.638436726635788 42.9209 41.8072 32.3067 35.7818 GeneID:5682,Genbank:NM_148976.2,HGNC:HGNC:9530,MIM:602854 proteasome subunit alpha 1 GO:0000502,GO:0001530,GO:0002376,GO:0002862,GO:0004298,GO:0005634,GO:0005737,GO:0005839,GO:0006511,GO:0019773,GO:0070062 proteasome complex|lipopolysaccharide binding|immune system process|negative regulation of inflammatory response to antigenic stimulus|threonine-type endopeptidase activity|nucleus|cytoplasm|proteasome core complex|ubiquitin-dependent protein catabolic process|proteasome core complex, alpha-subunit complex|extracellular exosome hsa03050 Proteasome PSMA2 3253.29922676087 3351.81564692812 3154.78280659362 0.941216086715545 -0.0874021164135393 0.516163235594757 1 88.992 94.4961 85.4854 89.393 GeneID:5683,Genbank:NM_002787.4,HGNC:HGNC:9531,MIM:176842 proteasome subunit alpha 2 GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0002223,GO:0002479,GO:0004298,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0009615,GO:0010972,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|P-body|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|extracellular region|nucleus|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|response to virus|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050 Proteasome PSMA3 1241.77625250608 1321.89905981148 1161.65344520068 0.87877620955895 -0.186432281584879 0.213974490884513 1 66.5266 63.4266 57.5269 55.0175 GeneID:5684,Genbank:NM_002788.3,HGNC:HGNC:9532,MIM:176843 proteasome subunit alpha 3 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004298,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005839,GO:0006521,GO:0010972,GO:0016032,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045202,GO:0050852,GO:0051436,GO:0051437,GO:0052548,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|synapse|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of endopeptidase activity|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050 Proteasome PSMA4 4010.24532273525 4145.75326370494 3874.73738176555 0.934628072463437 -0.0975357242847444 0.539131245314354 1 96.8317 97.2407 82.5087 98.5829 GeneID:5685,Genbank:NM_002789.5,HGNC:HGNC:9533,MIM:176846 proteasome subunit alpha 4 GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0002223,GO:0002479,GO:0004298,GO:0005634,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0010972,GO:0016032,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043231,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|P-body|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|nucleus|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050 Proteasome PSMA5 2352.89185588957 2464.00483503868 2241.77887674046 0.909811070523029 -0.136361105529828 0.324419721682158 1 23.2711 24.4609 20.8338 22.1792 GeneID:5686,Genbank:NM_001199774.1,HGNC:HGNC:9534,MIM:176844 proteasome subunit alpha 5 GO:0000502,GO:0004298,GO:0005654,GO:0005829,GO:0005839,GO:0019773,GO:0043161 proteasome complex|threonine-type endopeptidase activity|nucleoplasm|cytosol|proteasome core complex|proteasome core complex, alpha-subunit complex|proteasome-mediated ubiquitin-dependent protein catabolic process hsa03050 Proteasome PSMA6 2593.55309422822 2719.06923577226 2468.03695268417 0.907677127236963 -0.13974889183273 0.302744559875637 1 29.0672 31.7471 26.7483 29.3642 GeneID:5687,Genbank:NM_001282234.1,HGNC:HGNC:9535,MIM:602855 proteasome subunit alpha 6 GO:0000502,GO:0000932,GO:0003723,GO:0004298,GO:0005634,GO:0005737,GO:0005839,GO:0005844,GO:0006511,GO:0016363,GO:0019773,GO:0030016,GO:0030017,GO:0051059,GO:0051092,GO:0051603,GO:0070062 proteasome complex|P-body|RNA binding|threonine-type endopeptidase activity|nucleus|cytoplasm|proteasome core complex|polysome|ubiquitin-dependent protein catabolic process|nuclear matrix|proteasome core complex, alpha-subunit complex|myofibril|sarcomere|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|proteolysis involved in cellular protein catabolic process|extracellular exosome hsa03050 Proteasome PSMA7 6466.85453364553 6584.51487856871 6349.19418872236 0.964261499262113 -0.0525036491284737 0.714635919661548 1 255.703 279.711 250.119 273.475 GeneID:5688,Genbank:NM_002792.3,HGNC:HGNC:9536,MIM:606607 proteasome subunit alpha 7 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004298,GO:0005634,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0010972,GO:0016032,GO:0016579,GO:0019773,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:0098794,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|nucleus|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, alpha-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|postsynapse|regulation of hematopoietic stem cell differentiation hsa03050 Proteasome PSMB1 5251.23695824712 5071.94353242621 5430.53038406804 1.07070008752055 0.0985544251486823 0.458205974208508 1 271.622 269.427 283.832 291.46 GeneID:5689,Genbank:NM_002793.3,HGNC:HGNC:9537,MIM:602017 proteasome subunit beta 1 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004298,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|extracellular region|nucleus|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050 Proteasome PSMB10 479.447971112646 488.823374462969 470.072567762322 0.961640936828673 -0.0564297823421879 0.733539391256057 1 19.5006 21.3695 18.9743 18.1881 GeneID:5699,Genbank:NM_002801.3,HGNC:HGNC:9538,MIM:176847 proteasome subunit beta 10 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004298,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0006959,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1990111 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|humoral immune response|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex hsa03050 Proteasome PSMB11 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.0884051 0 0 GeneID:122706,Genbank:NM_001099780.1,HGNC:HGNC:31963,MIM:611137 proteasome subunit beta 11 GO:0000165,GO:0000209,GO:0002223,GO:0002479,GO:0004298,GO:0005634,GO:0005829,GO:0006508,GO:0006521,GO:0008233,GO:0010972,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043374,GO:0043488,GO:0043687,GO:0050852,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|nucleus|cytosol|proteolysis|regulation of cellular amino acid metabolic process|peptidase activity|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|CD8-positive, alpha-beta T cell differentiation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050 Proteasome PSMB2 6561.14626489146 6707.80078809957 6414.49174168335 0.956273441075265 -0.0645048870615949 0.622252339950914 1 49.7759 51.5162 48.77 46.6878 GeneID:5690,Genbank:NM_002794.4,HGNC:HGNC:9539,MIM:602175 proteasome subunit beta 2 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004298,GO:0005634,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0010243,GO:0010972,GO:0014070,GO:0016020,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|nucleus|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|response to organonitrogen compound|negative regulation of G2/M transition of mitotic cell cycle|response to organic cyclic compound|membrane|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050 Proteasome PSMB3 5027.71078418008 5275.85247026091 4779.56909809926 0.905933045899386 -0.142523664834724 0.295538911331709 1 299.485 316.641 270.216 291.853 GeneID:5691,Genbank:NM_002795.3,HGNC:HGNC:9540,MIM:602176 proteasome subunit beta 3 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004298,GO:0005634,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|nucleus|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050 Proteasome PSMB4 5942.62155399798 5706.0877905522 6179.15531744377 1.08290575684357 0.114907693499705 0.394428157209213 1 322.327 330.543 345.473 372.593 GeneID:5692,Genbank:NM_002796.2,HGNC:HGNC:9541,MIM:602177 proteasome subunit beta 4 GO:0000165,GO:0000209,GO:0000502,GO:0001530,GO:0002223,GO:0002479,GO:0002862,GO:0004298,GO:0005634,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|lipopolysaccharide binding|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|negative regulation of inflammatory response to antigenic stimulus|threonine-type endopeptidase activity|nucleus|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050 Proteasome PSMB5 3577.88372080843 3549.35162253566 3606.4158190812 1.01607735795553 0.0230102443249254 0.884716279444349 1 76.0013 83.1565 79.5319 84.394 GeneID:5693,Genbank:XM_005267871.3,HGNC:HGNC:9542,MIM:600306 proteasome subunit beta 5 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004298,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0005839,GO:0006508,GO:0006521,GO:0006979,GO:0008233,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|nucleus|nucleoplasm|centrosome|cytosol|proteasome core complex|proteolysis|regulation of cellular amino acid metabolic process|response to oxidative stress|peptidase activity|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050 Proteasome PSMB6 4088.44388779378 4006.48405200567 4170.4037235819 1.04091359642232 0.0578503191786436 0.721363606633742 1 183.082 197.806 188.57 210.562 GeneID:5694,Genbank:NM_001270481.1,HGNC:HGNC:9543,MIM:600307 proteasome subunit beta 6 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004175,GO:0004298,GO:0005634,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045296,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase activity|threonine-type endopeptidase activity|nucleus|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|cadherin binding|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050 Proteasome PSMB7 4641.00298876948 4601.34209473249 4680.66388280647 1.01723883737416 0.0246584491476277 0.880438181475547 1 161.769 172.105 164.477 182.136 GeneID:5695,Genbank:NM_002799.3,HGNC:HGNC:9544,MIM:604030 proteasome subunit beta 7 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004298,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1903955,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|extracellular region|nucleus|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|positive regulation of protein targeting to mitochondrion|ficolin-1-rich granule lumen hsa03050 Proteasome PSMB8 1109.09657753675 916.773050879601 1301.42010419389 1.4195662742761 0.505450204706909 0.0659418303127254 0.906544510118979 18.8887 21.0706 33.8568 23.1445 GeneID:5696,Genbank:NM_004159.4,HGNC:HGNC:9545,MIM:177046 proteasome subunit beta 8 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004298,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045444,GO:0050852,GO:0051436,GO:0051437,GO:0052548,GO:0055085,GO:0060071,GO:0060337,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1990111 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|fat cell differentiation|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of endopeptidase activity|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|type I interferon signaling pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex hsa03050 Proteasome PSMB9 79.3476641631677 65.1206445296815 93.574683796654 1.43694345276333 0.523003289336589 0.542252123432531 1 3.10083 2.88527 7.04918 2.08102 GeneID:5698,Genbank:NM_002800.4,HGNC:HGNC:9546,MIM:177045 proteasome subunit beta 9 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0004298,GO:0005654,GO:0005829,GO:0005839,GO:0006521,GO:0010972,GO:0016032,GO:0016579,GO:0019774,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1990111,GO:2000116 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|threonine-type endopeptidase activity|nucleoplasm|cytosol|proteasome core complex|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|viral process|protein deubiquitination|proteasome core complex, beta-subunit complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex|regulation of cysteine-type endopeptidase activity hsa03050 Proteasome PSMC1 3170.24506767583 3249.11034092432 3091.37979442735 0.951454235176237 -0.0717938301612173 0.614964374884124 1 32.8115 30.8917 30.6249 30.2484 GeneID:5700,Genbank:NM_002802.2,HGNC:HGNC:9547,MIM:602706 proteasome 26S subunit, ATPase 1 GO:0000502,GO:0003723,GO:0005524,GO:0005634,GO:0005654,GO:0005838,GO:0008540,GO:0016020,GO:0016887,GO:0017025,GO:0022624,GO:0030433,GO:0031595,GO:0031597,GO:0036402,GO:0045899,GO:1901215 proteasome complex|RNA binding|ATP binding|nucleus|nucleoplasm|proteasome regulatory particle|proteasome regulatory particle, base subcomplex|membrane|ATPase activity|TBP-class protein binding|proteasome accessory complex|ubiquitin-dependent ERAD pathway|nuclear proteasome complex|cytosolic proteasome complex|proteasome-activating ATPase activity|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of neuron death hsa03050,hsa05165,hsa05169,hsa05203 Proteasome|Human papillomavirus infection|Epstein-Barr virus infection|Viral carcinogenesis PSMC2 4525.30051608349 4597.36942923873 4453.23160292825 0.968647760740353 -0.0459559557878912 0.737120718912136 1 53.0361 53.7194 52.3859 51.087 GeneID:5701,Genbank:NM_002803.3,HGNC:HGNC:9548,MIM:154365 proteasome 26S subunit, ATPase 2 GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0001649,GO:0002223,GO:0002479,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016032,GO:0016579,GO:0016887,GO:0017025,GO:0022624,GO:0030433,GO:0031145,GO:0031146,GO:0031595,GO:0031597,GO:0033209,GO:0034774,GO:0036402,GO:0036464,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0045899,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|P-body|osteoblast differentiation|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|viral process|protein deubiquitination|ATPase activity|TBP-class protein binding|proteasome accessory complex|ubiquitin-dependent ERAD pathway|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|nuclear proteasome complex|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|proteasome-activating ATPase activity|cytoplasmic ribonucleoprotein granule|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMC3 7174.55761007145 6885.33313112368 7463.78208901922 1.08401176048851 0.116380408634967 0.398447725752038 1 102.016 108.024 108.953 118.526 GeneID:5702,Genbank:NM_002804.4,HGNC:HGNC:9549,MIM:186852 proteasome 26S subunit, ATPase 3 GO:0000165,GO:0000209,GO:0000502,GO:0000932,GO:0001824,GO:0002223,GO:0002479,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016032,GO:0016579,GO:0016887,GO:0017025,GO:0022624,GO:0030433,GO:0031145,GO:0031146,GO:0031595,GO:0031597,GO:0033209,GO:0034774,GO:0036402,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0043921,GO:0045899,GO:0045944,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|P-body|blastocyst development|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ATP binding|extracellular region|nucleus|nucleoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|viral process|protein deubiquitination|ATPase activity|TBP-class protein binding|proteasome accessory complex|ubiquitin-dependent ERAD pathway|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|nuclear proteasome complex|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|proteasome-activating ATPase activity|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|modulation by host of viral transcription|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMC3IP 1025.53216610633 1022.2500041566 1028.81432805606 1.00642144668405 0.00923457126370955 0.939753611832287 1 16.2209 15.0736 15.567 15.8218 GeneID:29893,Genbank:NM_013290.6,HGNC:HGNC:17928,MIM:608665 PSMC3 interacting protein GO:0003677,GO:0005654,GO:0007131,GO:0030374 DNA binding|nucleoplasm|reciprocal meiotic recombination|ligand-dependent nuclear receptor transcription coactivator activity PSMC4 4075.36193452591 4018.94552546185 4131.77834358998 1.02807522953802 0.0399458377908977 0.777100940829275 1 73.0422 75.5136 74.515 78.3624 GeneID:5704,Genbank:NM_006503.3,HGNC:HGNC:9551,MIM:602707 proteasome 26S subunit, ATPase 4 GO:0000165,GO:0000209,GO:0000502,GO:0001824,GO:0002223,GO:0002479,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006508,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016234,GO:0016579,GO:0016887,GO:0017025,GO:0022624,GO:0030433,GO:0031145,GO:0031146,GO:0031595,GO:0031597,GO:0033209,GO:0036402,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0045202,GO:0045899,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|blastocyst development|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ATP binding|nucleus|nucleoplasm|cytosol|proteolysis|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|inclusion body|protein deubiquitination|ATPase activity|TBP-class protein binding|proteasome accessory complex|ubiquitin-dependent ERAD pathway|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|nuclear proteasome complex|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|proteasome-activating ATPase activity|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|synapse|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMC5 5999.25056091855 6093.88103797365 5904.62008386344 0.968942459997029 -0.04551710018789 0.716409158939958 1 95.0924 99.4381 97.946 97.909 GeneID:5705,Genbank:NM_002805.5,HGNC:HGNC:9552,MIM:601681 proteasome 26S subunit, ATPase 5 GO:0000502,GO:0005524,GO:0005634,GO:0005737,GO:0008134,GO:0008540,GO:0017025,GO:0022624,GO:0030433,GO:0031531,GO:0031595,GO:0031597,GO:0036402,GO:0043161,GO:0045899 proteasome complex|ATP binding|nucleus|cytoplasm|transcription factor binding|proteasome regulatory particle, base subcomplex|TBP-class protein binding|proteasome accessory complex|ubiquitin-dependent ERAD pathway|thyrotropin-releasing hormone receptor binding|nuclear proteasome complex|cytosolic proteasome complex|proteasome-activating ATPase activity|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMC6 830.098742285666 895.899860347573 764.297624223759 0.853106087020978 -0.229202937514465 0.155315808935676 1 10.6669 10.0661 9.66238 8.58878 GeneID:5706,Genbank:NM_002806.3,HGNC:HGNC:9553,MIM:602708 proteasome 26S subunit, ATPase 6 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0016887,GO:0017025,GO:0022624,GO:0030433,GO:0030674,GO:0031145,GO:0031146,GO:0031595,GO:0031597,GO:0033209,GO:0036402,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043488,GO:0043687,GO:0045899,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|ATP binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|ATPase activity|TBP-class protein binding|proteasome accessory complex|ubiquitin-dependent ERAD pathway|protein binding, bridging|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|nuclear proteasome complex|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|proteasome-activating ATPase activity|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD1 3453.04907200997 3526.27496401981 3379.82318000014 0.958468416242641 -0.0611972023584172 0.663406275100379 1 26.9813 26.4579 26.2812 24.8993 GeneID:5707,Genbank:NM_002807.3,HGNC:HGNC:9554,MIM:617842 proteasome 26S subunit, non-ATPase 1 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0033209,GO:0034515,GO:0035578,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|proteasome storage granule|azurophil granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD10 1313.05536653047 1419.0096326382 1207.10110042274 0.850664486454908 -0.233337869170948 0.119077263256367 1 38.0749 41.1939 30.9905 36.4732 GeneID:5716,Genbank:NM_170750.2,HGNC:HGNC:9555,MIM:300880 proteasome 26S subunit, non-ATPase 10 GO:0000122,GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005838,GO:0006521,GO:0006915,GO:0007253,GO:0008134,GO:0010972,GO:0016579,GO:0030307,GO:0031145,GO:0031146,GO:0031398,GO:0032088,GO:0032436,GO:0033209,GO:0038061,GO:0038095,GO:0043066,GO:0043161,GO:0043409,GO:0043488,GO:0043518,GO:0043687,GO:0045111,GO:0045737,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070682,GO:0090090,GO:0090201,GO:0090263,GO:1902036 negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|apoptotic process|cytoplasmic sequestering of NF-kappaB|transcription factor binding|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|positive regulation of cell growth|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of MAPK cascade|regulation of mRNA stability|negative regulation of DNA damage response, signal transduction by p53 class mediator|post-translational protein modification|intermediate filament cytoskeleton|positive regulation of cyclin-dependent protein serine/threonine kinase activity|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome regulatory particle assembly|negative regulation of canonical Wnt signaling pathway|negative regulation of release of cytochrome c from mitochondria|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation PSMD11 5244.2868629871 5180.30714718858 5308.26657878562 1.02470112832334 0.0352031843060517 0.801788566465903 1 55.3334 59.2961 63.2207 56.2573 GeneID:5717,Genbank:NM_001270482.1,HGNC:HGNC:9556,MIM:604449 proteasome 26S subunit, non-ATPase 11 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005198,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0006521,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043248,GO:0043312,GO:0043488,GO:0043687,GO:0048863,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|structural molecule activity|extracellular region|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|stem cell differentiation|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD12 1717.06365242713 1806.10784390128 1628.01946095298 0.901396595142613 -0.149766094335027 0.394651981928245 1 14.0245 13.0521 14.3122 10.8482 GeneID:5718,Genbank:NM_174871.3,HGNC:HGNC:9557,MIM:604450 proteasome 26S subunit, non-ATPase 12 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005576,GO:0005654,GO:0005737,GO:0005829,GO:0005838,GO:0006521,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0031595,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|extracellular region|nucleoplasm|cytoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|nuclear proteasome complex|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD13 3393.63697504725 3352.47922311945 3434.79472697505 1.02455362088091 0.0349954909910611 0.808364958198608 1 68.0619 73.2252 68.3455 78.4295 GeneID:5719,Genbank:NM_002817.3,HGNC:HGNC:9558,MIM:603481 proteasome 26S subunit, non-ATPase 13 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005198,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006511,GO:0006521,GO:0007127,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043248,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|structural molecule activity|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|meiosis I|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD14 1696.58636720597 1660.62733210741 1732.54540230454 1.04330777219345 0.0611648107036844 0.650557536330715 1 36.3668 33.6162 37.1748 36.3333 GeneID:10213,Genbank:NM_005805.5,HGNC:HGNC:16889,MIM:607173 proteasome 26S subunit, non-ATPase 14 GO:0000165,GO:0000209,GO:0000502,GO:0000724,GO:0002223,GO:0002479,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006303,GO:0006511,GO:0006521,GO:0008237,GO:0008541,GO:0010972,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0031597,GO:0033209,GO:0034774,GO:0036459,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0045471,GO:0046872,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061133,GO:0061136,GO:0061418,GO:0061578,GO:0070062,GO:0070498,GO:0070536,GO:0070628,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|double-strand break repair via homologous recombination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|extracellular region|nucleus|nucleoplasm|cytosol|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|metallopeptidase activity|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|cytosolic proteasome complex|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|thiol-dependent ubiquitinyl hydrolase activity|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|response to ethanol|metal ion binding|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|endopeptidase activator activity|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|Lys63-specific deubiquitinase activity|extracellular exosome|interleukin-1-mediated signaling pathway|protein K63-linked deubiquitination|proteasome binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD2 22612.4139697824 22388.17206516 22836.6558744049 1.02003217627324 0.0286146618219468 0.835189524801376 1 234.133 248.338 247.355 249.634 GeneID:5708,Genbank:NM_002808.4,HGNC:HGNC:9559,MIM:606223 proteasome 26S subunit, non-ATPase 2 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0008540,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0033209,GO:0034515,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|proteasome storage granule|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD3 6733.59410754086 6582.23192434317 6884.95629073855 1.04599114249922 0.0648706348290642 0.631226411167086 1 116.534 118.023 125.37 124.693 GeneID:5709,Genbank:NM_002809.3,HGNC:HGNC:9560,MIM:617676 proteasome 26S subunit, non-ATPase 3 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0006521,GO:0008541,GO:0010972,GO:0016020,GO:0016579,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|extracellular region|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD4 4403.33287410753 4395.33184346848 4411.33390474659 1.00364069468427 0.00524287409498559 0.975817042925213 1 100.675 102.881 100.148 107.69 GeneID:5710,Genbank:NM_001330692.1,HGNC:HGNC:9561,MIM:601648 proteasome 26S subunit, non-ATPase 4 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0003723,GO:0005634,GO:0005654,GO:0005829,GO:0006521,GO:0008540,GO:0010972,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0031593,GO:0033209,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043248,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|RNA binding|nucleus|nucleoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome regulatory particle, base subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|polyubiquitin modification-dependent protein binding|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD5 1438.86350593807 1469.87897189068 1407.84803998545 0.957798612612681 -0.0622057490798455 0.676971517008011 1 17.8435 17.9448 17.7821 16.9865 GeneID:5711,Genbank:NM_001270427.1,HGNC:HGNC:9563,MIM:604452 proteasome 26S subunit, non-ATPase 5 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005654,GO:0005829,GO:0006521,GO:0010972,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070682,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|nucleoplasm|cytosol|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome regulatory particle assembly|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation PSMD6 2569.16011396959 2690.9498184145 2447.37040952467 0.90948199508479 -0.136883017603235 0.328736856827407 1 44.3757 41.9201 40.3775 39.4488 GeneID:9861,Genbank:NM_001271780.1,HGNC:HGNC:9564,MIM:617857 proteasome 26S subunit, non-ATPase 6 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005576,GO:0005654,GO:0005829,GO:0005838,GO:0006508,GO:0006521,GO:0010972,GO:0016579,GO:0016887,GO:0022624,GO:0030234,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|extracellular region|nucleoplasm|cytosol|proteasome regulatory particle|proteolysis|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|ATPase activity|proteasome accessory complex|enzyme regulator activity|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD7 2236.37347690701 2270.20815120403 2202.53880261 0.970192447525952 -0.0436571459867329 0.762341777138563 1 44.135 43.7265 42.2941 44.1735 GeneID:5713,Genbank:NM_002811.4,HGNC:HGNC:9565,MIM:157970 proteasome 26S subunit, non-ATPase 7 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005576,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0010972,GO:0016020,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0034774,GO:0038061,GO:0038095,GO:0042803,GO:0043161,GO:0043312,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1904813 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|extracellular region|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|secretory granule lumen|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|neutrophil degranulation|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|ficolin-1-rich granule lumen hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD8 7313.31584829313 7191.3355316955 7435.29616489075 1.03392424565924 0.0481304850576526 0.735127925855397 1 183.783 197.948 195.585 208.359 GeneID:5714,Genbank:NM_002812.4,HGNC:HGNC:9566,MIM:617844 proteasome 26S subunit, non-ATPase 8 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005634,GO:0005654,GO:0005829,GO:0005838,GO:0006521,GO:0008541,GO:0010972,GO:0016579,GO:0022624,GO:0031145,GO:0031146,GO:0031647,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043248,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:1903955 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|nucleus|nucleoplasm|cytosol|proteasome regulatory particle|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|proteasome accessory complex|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|regulation of protein stability|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|positive regulation of protein targeting to mitochondrion hsa03050,hsa05169 Proteasome|Epstein-Barr virus infection PSMD9 1312.35671640909 1314.86658939641 1309.84684342177 0.996182315365589 -0.00551829495980446 0.965069681013704 1 26.7926 27.3297 25.5172 29.3015 GeneID:5715,Genbank:NM_002813.6,HGNC:HGNC:9567,MIM:603146 proteasome 26S subunit, non-ATPase 9 GO:0000165,GO:0000209,GO:0002223,GO:0002479,GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005838,GO:0006511,GO:0006521,GO:0010972,GO:0016579,GO:0031145,GO:0031146,GO:0032024,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043425,GO:0043488,GO:0043687,GO:0045893,GO:0046676,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070682,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|cytosol|proteasome regulatory particle|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of insulin secretion|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|bHLH transcription factor binding|regulation of mRNA stability|post-translational protein modification|positive regulation of transcription, DNA-templated|negative regulation of insulin secretion|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome regulatory particle assembly|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation PSME1 1225.19974834267 1212.62599683266 1237.77349985267 1.02073805368324 0.0296126829264705 0.851318059352614 1 31.3452 31.2727 33.6413 30.3533 GeneID:5720,Genbank:NM_176783.2,HGNC:HGNC:9568,MIM:600654 proteasome activator subunit 1 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0008537,GO:0010950,GO:0010972,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061133,GO:0061136,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:2000045 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome activator complex|positive regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|endopeptidase activator activity|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|regulation of G1/S transition of mitotic cell cycle hsa03050,hsa04612 Proteasome|Antigen processing and presentation PSME2 2149.1835065038 2219.79168273478 2078.57533027282 0.936383060824889 -0.0948292585632053 0.486289690900316 1 44.2744 46.0829 46.203 41.6344 GeneID:5721,Genbank:NM_002818.2,HGNC:HGNC:9569,MIM:602161 proteasome activator subunit 2 GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005654,GO:0005737,GO:0005829,GO:0006521,GO:0008537,GO:0010950,GO:0010972,GO:0016020,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0035722,GO:0038061,GO:0038095,GO:0042802,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061133,GO:0061136,GO:0061418,GO:0070062,GO:0070498,GO:0090090,GO:0090263,GO:1902036,GO:2000045 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|nucleoplasm|cytoplasm|cytosol|regulation of cellular amino acid metabolic process|proteasome activator complex|positive regulation of endopeptidase activity|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|interleukin-12-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|endopeptidase activator activity|regulation of proteasomal protein catabolic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|regulation of G1/S transition of mitotic cell cycle hsa03050,hsa04612 Proteasome|Antigen processing and presentation PSME3 5498.19621530536 5670.84086723085 5325.55156337987 0.939111445386125 -0.0906317206446872 0.484298463846288 1 53.0862 56.937 53.9721 51.2275 GeneID:10197,Genbank:NM_001267045.1,HGNC:HGNC:9570,MIM:605129 proteasome activator subunit 3 GO:0000502,GO:0002039,GO:0005634,GO:0005737,GO:0006915,GO:0007049,GO:0008537,GO:0010950,GO:0061133,GO:0061136,GO:0097371,GO:2000045,GO:2001237 proteasome complex|p53 binding|nucleus|cytoplasm|apoptotic process|cell cycle|proteasome activator complex|positive regulation of endopeptidase activity|endopeptidase activator activity|regulation of proteasomal protein catabolic process|MDM2/MDM4 family protein binding|regulation of G1/S transition of mitotic cell cycle|negative regulation of extrinsic apoptotic signaling pathway hsa03050,hsa04612,hsa05160 Proteasome|Antigen processing and presentation|Hepatitis C PSME4 961.340202360232 973.560447574298 949.119957146165 0.974895764829982 -0.0366801197192919 0.930726959478892 1 4.52832 4.05249 5.607 2.95216 GeneID:23198,Genbank:NM_014614.2,HGNC:HGNC:20635,MIM:607705 proteasome activator subunit 4 GO:0000165,GO:0000209,GO:0002223,GO:0002479,GO:0005634,GO:0005654,GO:0005829,GO:0005839,GO:0006281,GO:0006521,GO:0006974,GO:0007275,GO:0010499,GO:0010972,GO:0016504,GO:0016579,GO:0016607,GO:0031145,GO:0031146,GO:0033209,GO:0035093,GO:0038061,GO:0038095,GO:0043161,GO:0043488,GO:0043687,GO:0050852,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070577,GO:0070628,GO:0090090,GO:0090263,GO:1902036,GO:1990111 MAPK cascade|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|nucleus|nucleoplasm|cytosol|proteasome core complex|DNA repair|regulation of cellular amino acid metabolic process|cellular response to DNA damage stimulus|multicellular organism development|proteasomal ubiquitin-independent protein catabolic process|negative regulation of G2/M transition of mitotic cell cycle|peptidase activator activity|protein deubiquitination|nuclear speck|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|spermatogenesis, exchange of chromosomal proteins|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|lysine-acetylated histone binding|proteasome binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation|spermatoproteasome complex hsa03050 Proteasome PSMF1 1880.09049045273 1878.38069670904 1881.80028419641 1.00182049756653 0.00262403501056679 0.994482788324708 1 7.08173 7.5624 7.7328 7.3815 GeneID:9491,Genbank:NM_178578.3,HGNC:HGNC:9571,MIM:617858 proteasome inhibitor subunit 1 GO:0000165,GO:0000209,GO:0002223,GO:0002479,GO:0004866,GO:0005654,GO:0005783,GO:0005829,GO:0005839,GO:0006511,GO:0006521,GO:0010972,GO:0016020,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0042803,GO:0043161,GO:0043488,GO:0043687,GO:0046982,GO:0048471,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0070628,GO:0090090,GO:0090263,GO:1901799,GO:1902036 MAPK cascade|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|endopeptidase inhibitor activity|nucleoplasm|endoplasmic reticulum|cytosol|proteasome core complex|ubiquitin-dependent protein catabolic process|regulation of cellular amino acid metabolic process|negative regulation of G2/M transition of mitotic cell cycle|membrane|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of mRNA stability|post-translational protein modification|protein heterodimerization activity|perinuclear region of cytoplasm|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|proteasome binding|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of proteasomal protein catabolic process|regulation of hematopoietic stem cell differentiation hsa03050 Proteasome PSMG1 1056.10884037983 1089.1780638158 1023.03961694385 0.939276736220477 -0.0903778175697262 0.550301396604458 1 30.8232 32.3955 32.1156 28.7387 GeneID:8624,Genbank:NM_203433.2,HGNC:HGNC:3043,MIM:605296 proteasome assembly chaperone 1 GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005794,GO:0005829,GO:0021930,GO:0043248,GO:0070628,GO:0080129 nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|Golgi apparatus|cytosol|cerebellar granule cell precursor proliferation|proteasome assembly|proteasome binding|proteasome core complex assembly PSMG2 766.017958039553 797.830796028872 734.205120050233 0.920251667025979 -0.119899636849138 0.459181835772299 1 35.2351 34.3984 32.655 32.0058 GeneID:56984,Genbank:NM_147163.1,HGNC:HGNC:24929,MIM:609702 proteasome assembly chaperone 2 GO:0000502,GO:0005634,GO:0005829,GO:0007094,GO:0043066,GO:0043248 proteasome complex|nucleus|cytosol|mitotic spindle assembly checkpoint|negative regulation of apoptotic process|proteasome assembly PSMG3 1099.29084567901 1134.43915458611 1064.14253677191 0.938034034236191 -0.0922878265891329 0.681250663842789 1 34.9943 42.7074 34.9044 39.2485 GeneID:84262,Genbank:XM_024446976.1,HGNC:HGNC:22420,MIM:617528 proteasome assembly chaperone 3 PSMG4 320.951465388984 298.812991675023 343.089939102945 1.14817611235617 0.199343945964997 0.307651856283953 1 0.766259 0.765596 0.759867 0.854311 GeneID:389362,Genbank:XM_011514595.2,HGNC:HGNC:21108,MIM:617550 proteasome assembly chaperone 4 GO:0043248 proteasome assembly PSORS1C1 31.6848206780222 30.4128358858255 32.9568054702189 1.08364789110571 0.115896059019807 0.876545077337012 1 0.333157 0.641883 0.487609 0.624222 GeneID:170679,Genbank:NM_014068.2,HGNC:HGNC:17202,MIM:613525 psoriasis susceptibility 1 candidate 1 PSORS1C2 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0426432 0 0.0390542 0 GeneID:170680,Genbank:NM_014069.2,HGNC:HGNC:17199,MIM:613526 psoriasis susceptibility 1 candidate 2 GO:0005576 extracellular region PSPC1 1167.55147886397 1219.97605086117 1115.12690686676 0.914056391582118 -0.129644921566552 0.391408690287704 1 4.66654 4.7351 4.48638 4.12788 GeneID:55269,Genbank:NM_001354908.1,HGNC:HGNC:20320,MIM:612408 paraspeckle component 1 GO:0000398,GO:0000976,GO:0001047,GO:0001650,GO:0002218,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006355,GO:0016363,GO:0016607,GO:0042382,GO:0042752,GO:0045087,GO:0045892,GO:0048511 mRNA splicing, via spliceosome|transcription regulatory region sequence-specific DNA binding|core promoter binding|fibrillar center|activation of innate immune response|RNA binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear matrix|nuclear speck|paraspeckles|regulation of circadian rhythm|innate immune response|negative regulation of transcription, DNA-templated|rhythmic process PSPH 2163.95893946825 2119.66526325802 2208.25261567848 1.04179308589711 0.0590687674507687 0.746053245524756 1 23.052 26.4223 24.0935 28.5226 GeneID:5723,Genbank:XM_005271775.2,HGNC:HGNC:9577,MIM:172480 phosphoserine phosphatase GO:0000287,GO:0004647,GO:0005509,GO:0006563,GO:0006564 magnesium ion binding|phosphoserine phosphatase activity|calcium ion binding|L-serine metabolic process|L-serine biosynthetic process hsa00260 Glycine, serine and threonine metabolism PSPN 10.6949010024581 11.2138073152264 10.1759946896898 0.90745225092931 -0.140106362698913 0.920443914817279 1 0.280147 0.696438 0.511943 0.956497 GeneID:5623,Genbank:NM_004158.3,HGNC:HGNC:9579,MIM:602921 persephin GO:0000165,GO:0005088,GO:0005102,GO:0005576,GO:0005622,GO:0007399,GO:0007411,GO:0007417,GO:0008083 MAPK cascade|Ras guanyl-nucleotide exchange factor activity|receptor binding|extracellular region|intracellular|nervous system development|axon guidance|central nervous system development|growth factor activity PSRC1 1617.16139840054 1554.19087033756 1680.13192646352 1.0810331977427 0.112410827867522 0.448523801919929 1 18.5528 21.0614 21.1539 22.2877 GeneID:84722,Genbank:NM_001350242.1,HGNC:HGNC:24472,MIM:613126 proline and serine rich coiled-coil 1 GO:0000922,GO:0001578,GO:0005654,GO:0005737,GO:0005819,GO:0005829,GO:0007080,GO:0008017,GO:0015630,GO:0030308,GO:0030496,GO:0031116,GO:0045737,GO:0045893,GO:0051301,GO:0060236 spindle pole|microtubule bundle formation|nucleoplasm|cytoplasm|spindle|cytosol|mitotic metaphase plate congression|microtubule binding|microtubule cytoskeleton|negative regulation of cell growth|midbody|positive regulation of microtubule polymerization|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of transcription, DNA-templated|cell division|regulation of mitotic spindle organization PSTK 236.985664987896 258.320378757049 215.650951218742 0.834819739179628 -0.260463381692101 0.230963068538256 1 3.63505 3.72911 3.37656 2.77156 GeneID:118672,Genbank:NM_153336.2,HGNC:HGNC:28578,MIM:611310 phosphoseryl-tRNA kinase GO:0000049,GO:0001514,GO:0005524,GO:0005739,GO:0016301,GO:0097056 tRNA binding|selenocysteine incorporation|ATP binding|mitochondrion|kinase activity|selenocysteinyl-tRNA(Sec) biosynthetic process hsa00450,hsa00970 Selenocompound metabolism|Aminoacyl-tRNA biosynthesis PSTPIP2 0.969701619147642 0 1.93940323829528 Inf Inf 0.451735954600221 1 0 0 0.0115846 0 GeneID:9050,Genbank:XM_011526253.2,HGNC:HGNC:9581,MIM:616046 proline-serine-threonine phosphatase interacting protein 2 GO:0003779,GO:0005829,GO:0005856,GO:0007010,GO:0016020,GO:0016477 actin binding|cytosol|cytoskeleton|cytoskeleton organization|membrane|cell migration PTAFR 8.40277173744219 8.08127380474251 8.72426967014188 1.07956615268029 0.110451650233648 0.998260495321146 1 0.0523341 0.103879 0.0986315 0.0643927 GeneID:5724,Genbank:NM_001164722.2,HGNC:HGNC:9582,MIM:173393 platelet activating factor receptor GO:0001530,GO:0001816,GO:0001875,GO:0004930,GO:0004992,GO:0005543,GO:0005886,GO:0005887,GO:0006357,GO:0006935,GO:0006954,GO:0006955,GO:0007186,GO:0007567,GO:0009609,GO:0010863,GO:0016020,GO:0016021,GO:0019221,GO:0030667,GO:0032760,GO:0032959,GO:0043312,GO:0043315,GO:0045028,GO:0045056,GO:0045410,GO:0045727,GO:0045776,GO:0045907,GO:0048015,GO:0048661,GO:0051019,GO:0060333,GO:0060732,GO:0070821,GO:0071258,GO:0071320,GO:0071398,GO:0071548,GO:0097755,GO:1902943,GO:1903238,GO:1904058,GO:1904300,GO:1904303,GO:1904306,GO:1904317 lipopolysaccharide binding|cytokine production|lipopolysaccharide receptor activity|G-protein coupled receptor activity|platelet activating factor receptor activity|phospholipid binding|plasma membrane|integral component of plasma membrane|regulation of transcription from RNA polymerase II promoter|chemotaxis|inflammatory response|immune response|G-protein coupled receptor signaling pathway|parturition|response to symbiotic bacterium|positive regulation of phospholipase C activity|membrane|integral component of membrane|cytokine-mediated signaling pathway|secretory granule membrane|positive regulation of tumor necrosis factor production|inositol trisphosphate biosynthetic process|neutrophil degranulation|positive regulation of neutrophil degranulation|G-protein coupled purinergic nucleotide receptor activity|transcytosis|positive regulation of interleukin-6 biosynthetic process|positive regulation of translation|negative regulation of blood pressure|positive regulation of vasoconstriction|phosphatidylinositol-mediated signaling|positive regulation of smooth muscle cell proliferation|mitogen-activated protein kinase binding|interferon-gamma-mediated signaling pathway|positive regulation of inositol phosphate biosynthetic process|tertiary granule membrane|cellular response to gravity|cellular response to cAMP|cellular response to fatty acid|response to dexamethasone|positive regulation of blood vessel diameter|positive regulation of voltage-gated chloride channel activity|positive regulation of leukocyte tethering or rolling|positive regulation of sensory perception of pain|positive regulation of transcytosis|positive regulation of maternal process involved in parturition|positive regulation of gastro-intestinal system smooth muscle contraction|cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine hsa04020,hsa04080,hsa05150 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Staphylococcus aureus infection PTAR1 363.756819086093 369.30480431602 358.208833856167 0.969954437824322 -0.044011114462564 0.898706266798042 1 1.6283 1.53588 1.90468 1.1453 GeneID:375743,Genbank:NM_001099666.1,HGNC:HGNC:30449 protein prenyltransferase alpha subunit repeat containing 1 GO:0005737,GO:0008318,GO:0018342,GO:1990234 cytoplasm|protein prenyltransferase activity|protein prenylation|transferase complex PTBP1 12958.0114351439 12967.8857089234 12948.1371613645 0.998477118938111 -0.00219872758140621 0.968686028277355 1 148.25 153.199 153.283 152.466 GeneID:5725,Genbank:NM_002819.4,HGNC:HGNC:9583,MIM:600693 polypyrimidine tract binding protein 1 GO:0000381,GO:0003723,GO:0005634,GO:0006397,GO:0008380,GO:0048025,GO:0051148 regulation of alternative mRNA splicing, via spliceosome|RNA binding|nucleus|mRNA processing|RNA splicing|negative regulation of mRNA splicing, via spliceosome|negative regulation of muscle cell differentiation PTBP2 145.977273109935 167.879717459855 124.074828760015 0.739069797336801 -0.436217476772133 0.0927688512088635 0.987898138646211 2.02613 1.77985 1.53857 1.23576 GeneID:58155,Genbank:NM_001300986.1,HGNC:HGNC:17662,MIM:608449 polypyrimidine tract binding protein 2 GO:0003723,GO:0003729,GO:0005681,GO:0006376,GO:0021510,GO:0021549,GO:0030426,GO:0033119,GO:0036002,GO:0043025,GO:2000177 RNA binding|mRNA binding|spliceosomal complex|mRNA splice site selection|spinal cord development|cerebellum development|growth cone|negative regulation of RNA splicing|pre-mRNA binding|neuronal cell body|regulation of neural precursor cell proliferation PTBP3 769.967806860254 838.043025952135 701.892587768373 0.837537651448055 -0.255774046714476 0.497862959877283 1 5.47855 4.55729 5.41861 3.12239 GeneID:9991,Genbank:NM_001244896.1,HGNC:HGNC:10253,MIM:607527 polypyrimidine tract binding protein 3 GO:0003723,GO:0005634,GO:0006397,GO:0008380,GO:0009653,GO:0033119,GO:0043249,GO:0045595 RNA binding|nucleus|mRNA processing|RNA splicing|anatomical structure morphogenesis|negative regulation of RNA splicing|erythrocyte maturation|regulation of cell differentiation PTCD1 7.34005287645268 9.34957425676688 5.33053149613849 0.570136281048353 -0.810621283517993 0.49535159357553 1 0.79224 0.540672 0.740716 0.647833 GeneID:26024,Genbank:NM_015545.3,HGNC:HGNC:22198,MIM:614774 pentatricopeptide repeat domain 1 GO:0000049,GO:0003723,GO:0005739,GO:0005759,GO:0042780 tRNA binding|RNA binding|mitochondrion|mitochondrial matrix|tRNA 3'-end processing PTCD2 193.852784975769 198.216118106527 189.489451845011 0.955973982616157 -0.064956739925495 0.767829487531779 1 3.29584 4.03081 3.69259 3.50889 GeneID:79810,Genbank:NM_024754.4,HGNC:HGNC:25734,MIM:615484 pentatricopeptide repeat domain 2 GO:0001822,GO:0001889,GO:0003723,GO:0005739,GO:0006397,GO:0007005,GO:0048747,GO:0050684,GO:0055010 kidney development|liver development|RNA binding|mitochondrion|mRNA processing|mitochondrion organization|muscle fiber development|regulation of mRNA processing|ventricular cardiac muscle tissue morphogenesis PTCD3 1093.13256025436 1152.00020481315 1034.26491569557 0.897799246366733 -0.155535209664683 0.331601470154485 1 6.31138 5.38174 5.94891 4.91332 GeneID:55037,Genbank:NM_017952.5,HGNC:HGNC:24717,MIM:614918 pentatricopeptide repeat domain 3 GO:0003723,GO:0005654,GO:0005739,GO:0005743,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0019843,GO:0032543,GO:0043024,GO:0070125,GO:0070126 RNA binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|cytosol|ribosome|plasma membrane|regulation of translation|rRNA binding|mitochondrial translation|ribosomal small subunit binding|mitochondrial translational elongation|mitochondrial translational termination PTCH1 120.029339423025 121.323951274761 118.734727571289 0.978658593985222 -0.0311224328794595 0.935780329687366 1 0.544652 0.458552 0.492468 0.487528 GeneID:5727,Genbank:NM_001083602.2,HGNC:HGNC:9585,MIM:601309 patched 1 hsa04024,hsa04340,hsa04360,hsa05200,hsa05205,hsa05217 cAMP signaling pathway|Hedgehog signaling pathway|Axon guidance|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma PTCH2 10.1913660144005 11.6558524424989 8.72687958630208 0.748712256727157 -0.417516722735551 0.666473951171542 1 0.0694492 0.119987 0.128126 0.0299773 GeneID:8643,Genbank:NM_001166292.1,HGNC:HGNC:9586,MIM:603673 patched 2 hsa04340,hsa05200,hsa05217 Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma PTCHD1 21.9251573779433 18.6511222388488 25.1991925170377 1.35108183809711 0.43411506462731 0.47627369676534 1 0.0656162 0.0446608 0.0721329 0.0615623 GeneID:139411,Genbank:XM_011545449.3,HGNC:HGNC:26392,MIM:300828 patched domain containing 1 GO:0005886,GO:0007224,GO:0016021,GO:0021794,GO:0035176,GO:0050890 plasma membrane|smoothened signaling pathway|integral component of membrane|thalamus development|social behavior|cognition PTCHD4 6.96364033194117 6.65908587355536 7.26819479032697 1.09147035018583 0.126272940020996 0.984071081566489 1 0.00946485 0.0108357 0.00764917 0.0113955 GeneID:442213,Genbank:XM_017010893.1,HGNC:HGNC:21345,MIM:616908 patched domain containing 4 GO:0016021 integral component of membrane PTCRA 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0371888 0 0 0 GeneID:171558,Genbank:XM_024446346.1,HGNC:HGNC:21290,MIM:606817 pre T cell antigen receptor alpha GO:0016021 integral component of membrane hsa04330,hsa05202 Notch signaling pathway|Transcriptional misregulation in cancer PTDSS1 3619.06415734508 3811.33180682387 3426.79650786629 0.899107367595469 -0.153434688326178 0.249830577034257 1 63.1832 67.1186 60.2516 58.2177 GeneID:9791,Genbank:NM_014754.2,HGNC:HGNC:9587,MIM:612792 phosphatidylserine synthase 1 GO:0005789,GO:0006659,GO:0016020,GO:0016021,GO:0016740 endoplasmic reticulum membrane|phosphatidylserine biosynthetic process|membrane|integral component of membrane|transferase activity hsa00564 Glycerophospholipid metabolism PTDSS2 877.42188208742 887.888264129441 866.9555000454 0.976424100948597 -0.0344201894754832 0.807316674488157 1 5.43602 5.78927 5.47047 6.03478 GeneID:81490,Genbank:XM_024448699.1,HGNC:HGNC:15463,MIM:612793 phosphatidylserine synthase 2 GO:0003882,GO:0005789,GO:0006659,GO:0016020,GO:0016021,GO:0016740 CDP-diacylglycerol-serine O-phosphatidyltransferase activity|endoplasmic reticulum membrane|phosphatidylserine biosynthetic process|membrane|integral component of membrane|transferase activity hsa00564 Glycerophospholipid metabolism PTEN 506.513723182642 490.532703041411 522.494743323873 1.0651578173775 0.0910672008548265 0.650187224289747 1 2.59509 2.50023 3.19874 2.22895 GeneID:5728,Genbank:NM_000314.6,HGNC:HGNC:9588,MIM:601728 phosphatase and tensin homolog GO:0000287,GO:0004438,GO:0004722,GO:0004725,GO:0005737,GO:0006470,GO:0006915,GO:0007417,GO:0007507,GO:0008138,GO:0008285,GO:0010975,GO:0016314,GO:0016477,GO:0016605,GO:0030165,GO:0030336,GO:0031647,GO:0043491,GO:0046855,GO:0046856,GO:0051717,GO:0051800,GO:0051895,GO:0051898 magnesium ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|cytoplasm|protein dephosphorylation|apoptotic process|central nervous system development|heart development|protein tyrosine/serine/threonine phosphatase activity|negative regulation of cell proliferation|regulation of neuron projection development|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|cell migration|PML body|PDZ domain binding|negative regulation of cell migration|regulation of protein stability|protein kinase B signaling|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|negative regulation of focal adhesion assembly|negative regulation of protein kinase B signaling hsa00562,hsa01521,hsa04068,hsa04070,hsa04071,hsa04115,hsa04140,hsa04150,hsa04151,hsa04218,hsa04510,hsa04931,hsa05161,hsa05165,hsa05200,hsa05206,hsa05213,hsa05214,hsa05215,hsa05218,hsa05222,hsa05224,hsa05225,hsa05230 Inositol phosphate metabolism|EGFR tyrosine kinase inhibitor resistance|FoxO signaling pathway|Phosphatidylinositol signaling system|Sphingolipid signaling pathway|p53 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Cellular senescence|Focal adhesion|Insulin resistance|Hepatitis B|Human papillomavirus infection|Pathways in cancer|MicroRNAs in cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Central carbon metabolism in cancer PTGDR2 25.1985176720038 24.7240841610769 25.6729511829307 1.03837824752868 0.0543320664627867 0.968912553603714 1 0.0664835 0.0580842 0 0 GeneID:11251,Genbank:NM_004778.2,HGNC:HGNC:4502,MIM:604837 prostaglandin D2 receptor 2 GO:0001785,GO:0004930,GO:0004956,GO:0004958,GO:0005622,GO:0005886,GO:0005887,GO:0006935,GO:0006955,GO:0007186,GO:0007187,GO:0007193,GO:0007218,GO:0007268,GO:0019722,GO:0042923,GO:0043005,GO:0045745,GO:2000255 prostaglandin J receptor activity|G-protein coupled receptor activity|prostaglandin D receptor activity|prostaglandin F receptor activity|intracellular|plasma membrane|integral component of plasma membrane|chemotaxis|immune response|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission|calcium-mediated signaling|neuropeptide binding|neuron projection|positive regulation of G-protein coupled receptor protein signaling pathway|negative regulation of male germ cell proliferation PTGDS 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:5730,Genbank:NM_000954.5,HGNC:HGNC:9592,MIM:176803 prostaglandin D2 synthase hsa00590 Arachidonic acid metabolism PTGER1 1.94059982990028 0.490071401957362 3.3911282578432 6.91966159277795 2.7907014843419 0.357562461262114 1 0 0 0.0880309 0.245059 GeneID:5731,Genbank:NM_000955.2,HGNC:HGNC:9593,MIM:176802 prostaglandin E receptor 1 GO:0004957,GO:0005886,GO:0005887,GO:0007186,GO:0032496 prostaglandin E receptor activity|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|response to lipopolysaccharide hsa04020,hsa04080,hsa05163,hsa05200 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Human cytomegalovirus infection|Pathways in cancer PTGER3 0.971768182806039 0.490071401957362 1.45346496365472 2.96582285326082 1.56843242909583 0.837471602739444 1 0 0.00492865 0.0048792 0.00907629 GeneID:5733,Genbank:NM_198717.1,HGNC:HGNC:9595,MIM:176806 prostaglandin E receptor 3 GO:0004957,GO:0005635,GO:0005886,GO:0005887,GO:0007186,GO:0007200,GO:0008219,GO:0014827,GO:0016021,GO:0031622,GO:0060455 prostaglandin E receptor activity|nuclear envelope|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|cell death|intestine smooth muscle contraction|integral component of membrane|positive regulation of fever generation|negative regulation of gastric acid secretion hsa04020,hsa04024,hsa04080,hsa04923,hsa05163,hsa05200 Calcium signaling pathway|cAMP signaling pathway|Neuroactive ligand-receptor interaction|Regulation of lipolysis in adipocytes|Human cytomegalovirus infection|Pathways in cancer PTGER4 124.910195038503 106.353268878146 143.467121198861 1.34896766890388 0.431855771213541 0.117191592595489 1 0.937953 1.13751 1.68188 1.26055 GeneID:5734,Genbank:NM_000958.2,HGNC:HGNC:9596,MIM:601586 prostaglandin E receptor 4 hsa04080,hsa04750,hsa04924,hsa05163,hsa05165,hsa05200 Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels|Renin secretion|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer PTGES 21.8722363703632 17.0848554836069 26.6596172571196 1.56042392531209 0.641938023870196 0.289311645182106 1 0.417593 0.281868 0.734984 0.428542 GeneID:9536,Genbank:NM_004878.4,HGNC:HGNC:9599,MIM:605172 prostaglandin E synthase GO:0001516,GO:0002526,GO:0002544,GO:0005641,GO:0005789,GO:0006693,GO:0007165,GO:0008285,GO:0014070,GO:0016020,GO:0016021,GO:0019371,GO:0032496,GO:0032526,GO:0034097,GO:0043295,GO:0048471,GO:0050220,GO:0051592 prostaglandin biosynthetic process|acute inflammatory response|chronic inflammatory response|nuclear envelope lumen|endoplasmic reticulum membrane|prostaglandin metabolic process|signal transduction|negative regulation of cell proliferation|response to organic cyclic compound|membrane|integral component of membrane|cyclooxygenase pathway|response to lipopolysaccharide|response to retinoic acid|response to cytokine|glutathione binding|perinuclear region of cytoplasm|prostaglandin-E synthase activity|response to calcium ion hsa00590 Arachidonic acid metabolism PTGES2 1461.81332635093 1568.19121858537 1355.43543411649 0.864330457952182 -0.210345093957285 0.141203997372594 1 24.9444 26.1663 22.3101 23.2656 GeneID:80142,Genbank:NM_198938.2,HGNC:HGNC:17822,MIM:608152 prostaglandin E synthase 2 GO:0000139,GO:0003677,GO:0005576,GO:0005634,GO:0005739,GO:0005829,GO:0009055,GO:0015035,GO:0016021,GO:0016829,GO:0019371,GO:0020037,GO:0035578,GO:0043295,GO:0043312,GO:0045454,GO:0045893,GO:0048471,GO:0050220 Golgi membrane|DNA binding|extracellular region|nucleus|mitochondrion|cytosol|electron transfer activity|protein disulfide oxidoreductase activity|integral component of membrane|lyase activity|cyclooxygenase pathway|heme binding|azurophil granule lumen|glutathione binding|neutrophil degranulation|cell redox homeostasis|positive regulation of transcription, DNA-templated|perinuclear region of cytoplasm|prostaglandin-E synthase activity hsa00590 Arachidonic acid metabolism PTGES3 6145.55345606185 6659.56984295219 5631.5370691715 0.845630754234277 -0.241900248707858 0.0681848282825655 0.917687571238293 56.9623 55.6905 46.2125 50.3159 GeneID:10728,Genbank:NM_001282603.1,HGNC:HGNC:16049,MIM:607061 prostaglandin E synthase 3 GO:0000723,GO:0000781,GO:0001516,GO:0003720,GO:0005634,GO:0005654,GO:0005697,GO:0005829,GO:0006805,GO:0007004,GO:0007165,GO:0019371,GO:0042327,GO:0043234,GO:0050220,GO:0050821,GO:0051082,GO:0051085,GO:0051131,GO:0051879,GO:0051973,GO:0070062,GO:0070182,GO:1900034,GO:1905323 telomere maintenance|chromosome, telomeric region|prostaglandin biosynthetic process|telomerase activity|nucleus|nucleoplasm|telomerase holoenzyme complex|cytosol|xenobiotic metabolic process|telomere maintenance via telomerase|signal transduction|cyclooxygenase pathway|positive regulation of phosphorylation|protein complex|prostaglandin-E synthase activity|protein stabilization|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone-mediated protein complex assembly|Hsp90 protein binding|positive regulation of telomerase activity|extracellular exosome|DNA polymerase binding|regulation of cellular response to heat|telomerase holoenzyme complex assembly hsa00590 Arachidonic acid metabolism PTGES3L 5.93133812602471 3.6226049124413 8.24007133960811 2.27462600498023 1.18562935624965 0.354679912995539 1 0.368712 0.315359 0.448285 0.301648 GeneID:100885848,Genbank:NM_001142654.1,HGNC:HGNC:43943 prostaglandin E synthase 3 like PTGFR 43.044073620025 43.9133040765681 42.1748431634819 0.96041152107218 -0.058275384682211 0.949495544328953 1 0.368401 0.291589 0.429113 0.202745 GeneID:5737,Genbank:XM_017001873.1,HGNC:HGNC:9600,MIM:600563 prostaglandin F receptor GO:0004958,GO:0005576,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007567,GO:0008284,GO:0010628,GO:0032355,GO:0032496,GO:0035584,GO:0043066,GO:0071799 prostaglandin F receptor activity|extracellular region|cytoplasm|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|parturition|positive regulation of cell proliferation|positive regulation of gene expression|response to estradiol|response to lipopolysaccharide|calcium-mediated signaling using intracellular calcium source|negative regulation of apoptotic process|cellular response to prostaglandin D stimulus hsa04020,hsa04072,hsa04080 Calcium signaling pathway|Phospholipase D signaling pathway|Neuroactive ligand-receptor interaction PTGFRN 2381.86919543324 2430.31640381917 2333.4219870473 0.960130945658103 -0.0586969163779436 0.662945200093748 1 24.821 25.1549 22.9981 23.8799 GeneID:5738,Genbank:NM_020440.3,HGNC:HGNC:9601,MIM:601204 prostaglandin F2 receptor inhibitor GO:0005789,GO:0005794,GO:0005886,GO:0009986,GO:0016021,GO:0034389 endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|cell surface|integral component of membrane|lipid particle organization PTGR1 770.116755950265 747.921982270085 792.311529630446 1.05935050501609 0.0831800097117501 0.612805338684936 1 12.4372 12.5718 12.7733 14.2983 GeneID:22949,Genbank:NM_001146109.1,HGNC:HGNC:18429,MIM:601274 prostaglandin reductase 1 GO:0005737,GO:0006691,GO:0032440,GO:0036132,GO:0047522,GO:0070062,GO:0097327 cytoplasm|leukotriene metabolic process|2-alkenal reductase [NAD(P)] activity|13-prostaglandin reductase activity|15-oxoprostaglandin 13-oxidase activity|extracellular exosome|response to antineoplastic agent PTGR2 186.219411971814 191.181613689745 181.257210253883 0.948089132399691 -0.0769053977614638 0.774208957618684 1 2.60393 2.38229 2.58407 2.27399 GeneID:145482,Genbank:NM_001146154.1,HGNC:HGNC:20149,MIM:608642 prostaglandin reductase 2 GO:0005737,GO:0006693,GO:0036132,GO:0047522,GO:0070062 cytoplasm|prostaglandin metabolic process|13-prostaglandin reductase activity|15-oxoprostaglandin 13-oxidase activity|extracellular exosome PTGS1 4.41083684971277 4.4586688923012 4.36300480712434 0.978544249979619 -0.0312910035828327 1 1 0.00466389 0.0339595 0.0264494 0.00822591 GeneID:5742,Genbank:XM_024447615.1,HGNC:HGNC:9604,MIM:176805 prostaglandin-endoperoxide synthase 1 hsa00590,hsa04611,hsa04726,hsa04923 Arachidonic acid metabolism|Platelet activation|Serotonergic synapse|Regulation of lipolysis in adipocytes PTGS2 27.5107532746545 24.4839527876522 30.5375537616568 1.24724769838053 0.318748007058857 0.586095986847803 1 0.202887 0.284461 0.34885 0.20287 GeneID:5743,Genbank:NM_000963.3,HGNC:HGNC:9605,MIM:600262 prostaglandin-endoperoxide synthase 2 hsa00590,hsa04064,hsa04370,hsa04625,hsa04657,hsa04668,hsa04723,hsa04726,hsa04913,hsa04921,hsa04923,hsa05140,hsa05163,hsa05165,hsa05167,hsa05200,hsa05204,hsa05206,hsa05222 Arachidonic acid metabolism|NF-kappa B signaling pathway|VEGF signaling pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Retrograde endocannabinoid signaling|Serotonergic synapse|Ovarian steroidogenesis|Oxytocin signaling pathway|Regulation of lipolysis in adipocytes|Leishmaniasis|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Chemical carcinogenesis|MicroRNAs in cancer|Small cell lung cancer PTH1R 5.29546086210053 7.19718355019767 3.3937381740034 0.471536976976249 -1.08455718632306 0.438575364081152 1 0.0754468 0.0470183 0.0401133 0.00934971 GeneID:5745,Genbank:XM_011533967.3,HGNC:HGNC:9608,MIM:168468 parathyroid hormone 1 receptor GO:0001501,GO:0002062,GO:0002076,GO:0004991,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007187,GO:0007188,GO:0007189,GO:0007200,GO:0007204,GO:0007568,GO:0008284,GO:0008285,GO:0016323,GO:0016324,GO:0017046,GO:0030282,GO:0031526,GO:0042803,GO:0043235,GO:0043621,GO:0045453,GO:0048469,GO:0060732,GO:0070062 skeletal system development|chondrocyte differentiation|osteoblast development|parathyroid hormone receptor activity|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|aging|positive regulation of cell proliferation|negative regulation of cell proliferation|basolateral plasma membrane|apical plasma membrane|peptide hormone binding|bone mineralization|brush border membrane|protein homodimerization activity|receptor complex|protein self-association|bone resorption|cell maturation|positive regulation of inositol phosphate biosynthetic process|extracellular exosome hsa04080,hsa04928,hsa04961 Neuroactive ligand-receptor interaction|Parathyroid hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption PTHLH 2732.03397217753 2604.72093698364 2859.34700737142 1.09775560474538 0.134556900365362 0.333526465284694 1 29.751 32.5264 36.52 33.9603 GeneID:5744,Genbank:NM_198965.1,HGNC:HGNC:9607,MIM:168470 parathyroid hormone like hormone hsa04928 Parathyroid hormone synthesis, secretion and action PTK2 1555.26233255829 1506.2578914934 1604.26677362317 1.06506779661257 0.0909452677503094 0.546140253113906 1 5.83788 5.30175 6.95774 5.30051 GeneID:5747,Genbank:NM_001352699.1,HGNC:HGNC:9611,MIM:600758 protein tyrosine kinase 2 GO:0000226,GO:0001525,GO:0001568,GO:0001570,GO:0001725,GO:0001764,GO:0001932,GO:0001934,GO:0003779,GO:0004672,GO:0004713,GO:0004715,GO:0004871,GO:0005102,GO:0005524,GO:0005634,GO:0005737,GO:0005815,GO:0005829,GO:0005886,GO:0005925,GO:0007097,GO:0007155,GO:0007172,GO:0007173,GO:0007179,GO:0007229,GO:0008284,GO:0008360,GO:0008432,GO:0010507,GO:0010613,GO:0010632,GO:0014068,GO:0016324,GO:0018108,GO:0019901,GO:0021955,GO:0022408,GO:0030027,GO:0030155,GO:0030198,GO:0030335,GO:0031234,GO:0033628,GO:0038083,GO:0042127,GO:0042169,GO:0043066,GO:0043542,GO:0045087,GO:0045667,GO:0045860,GO:0046621,GO:0046777,GO:0048013,GO:0048471,GO:0050771,GO:0051893,GO:0051897,GO:0051964,GO:0060396,GO:0071560,GO:1900024,GO:2000060,GO:2000811 microtubule cytoskeleton organization|angiogenesis|blood vessel development|vasculogenesis|stress fiber|neuron migration|regulation of protein phosphorylation|positive regulation of protein phosphorylation|actin binding|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signal transducer activity|receptor binding|ATP binding|nucleus|cytoplasm|microtubule organizing center|cytosol|plasma membrane|focal adhesion|nuclear migration|cell adhesion|signal complex assembly|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|positive regulation of cell proliferation|regulation of cell shape|JUN kinase binding|negative regulation of autophagy|positive regulation of cardiac muscle hypertrophy|regulation of epithelial cell migration|positive regulation of phosphatidylinositol 3-kinase signaling|apical plasma membrane|peptidyl-tyrosine phosphorylation|protein kinase binding|central nervous system neuron axonogenesis|negative regulation of cell-cell adhesion|lamellipodium|regulation of cell adhesion|extracellular matrix organization|positive regulation of cell migration|extrinsic component of cytoplasmic side of plasma membrane|regulation of cell adhesion mediated by integrin|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|SH2 domain binding|negative regulation of apoptotic process|endothelial cell migration|innate immune response|regulation of osteoblast differentiation|positive regulation of protein kinase activity|negative regulation of organ growth|protein autophosphorylation|ephrin receptor signaling pathway|perinuclear region of cytoplasm|negative regulation of axonogenesis|regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of synapse assembly|growth hormone receptor signaling pathway|cellular response to transforming growth factor beta stimulus|regulation of substrate adhesion-dependent cell spreading|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of anoikis hsa01522,hsa04012,hsa04062,hsa04151,hsa04360,hsa04370,hsa04510,hsa04670,hsa04810,hsa05100,hsa05146,hsa05163,hsa05165,hsa05170,hsa05200,hsa05202,hsa05205,hsa05222,hsa05418 Endocrine resistance|ErbB signaling pathway|Chemokine signaling pathway|PI3K-Akt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Amoebiasis|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|Small cell lung cancer|Fluid shear stress and atherosclerosis PTK2B 85.7881951358498 72.2217755305093 99.3546147411903 1.37568778960882 0.460153089596117 0.15110653965898 1 0.415428 0.444609 0.602055 0.50165 GeneID:2185,Genbank:NM_173174.2,HGNC:HGNC:9612,MIM:601212 protein tyrosine kinase 2 beta GO:0000165,GO:0001525,GO:0001556,GO:0001666,GO:0001954,GO:0002040,GO:0002250,GO:0002315,GO:0004683,GO:0004713,GO:0004715,GO:0004871,GO:0004972,GO:0005102,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005856,GO:0005925,GO:0005938,GO:0006461,GO:0006468,GO:0006915,GO:0006950,GO:0006968,GO:0006970,GO:0007165,GO:0007166,GO:0007172,GO:0007173,GO:0007204,GO:0007229,GO:0008284,GO:0008285,GO:0008360,GO:0009612,GO:0009725,GO:0009749,GO:0010226,GO:0010595,GO:0010656,GO:0010752,GO:0010758,GO:0010976,GO:0014009,GO:0014069,GO:0017146,GO:0018108,GO:0030027,GO:0030155,GO:0030307,GO:0030335,GO:0030424,GO:0030425,GO:0030426,GO:0030502,GO:0030826,GO:0030838,GO:0031175,GO:0031234,GO:0031625,GO:0032403,GO:0032960,GO:0033209,GO:0035235,GO:0035902,GO:0038083,GO:0038110,GO:0042220,GO:0042542,GO:0042976,GO:0043025,GO:0043066,GO:0043149,GO:0043197,GO:0043267,GO:0043423,GO:0043507,GO:0043524,GO:0043534,GO:0043552,GO:0044297,GO:0045087,GO:0045121,GO:0045429,GO:0045453,GO:0045471,GO:0045638,GO:0045727,GO:0045766,GO:0045860,GO:0046330,GO:0046777,GO:0048010,GO:0048041,GO:0048167,GO:0048471,GO:0050731,GO:0050848,GO:0051000,GO:0051279,GO:0051591,GO:0051592,GO:0051968,GO:0060291,GO:0060292,GO:0070098,GO:0070374,GO:0071300,GO:0071498,GO:0090630,GO:0097440,GO:2000058,GO:2000060,GO:2000114,GO:2000249,GO:2000310,GO:2000463,GO:2000538,GO:2000573 MAPK cascade|angiogenesis|oocyte maturation|response to hypoxia|positive regulation of cell-matrix adhesion|sprouting angiogenesis|adaptive immune response|marginal zone B cell differentiation|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signal transducer activity|NMDA glutamate receptor activity|receptor binding|ATP binding|nucleus|cytoplasm|cytosol|cytoskeleton|focal adhesion|cell cortex|protein complex assembly|protein phosphorylation|apoptotic process|response to stress|cellular defense response|response to osmotic stress|signal transduction|cell surface receptor signaling pathway|signal complex assembly|epidermal growth factor receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|integrin-mediated signaling pathway|positive regulation of cell proliferation|negative regulation of cell proliferation|regulation of cell shape|response to mechanical stimulus|response to hormone|response to glucose|response to lithium ion|positive regulation of endothelial cell migration|negative regulation of muscle cell apoptotic process|regulation of cGMP-mediated signaling|regulation of macrophage chemotaxis|positive regulation of neuron projection development|glial cell proliferation|postsynaptic density|NMDA selective glutamate receptor complex|peptidyl-tyrosine phosphorylation|lamellipodium|regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell migration|axon|dendrite|growth cone|negative regulation of bone mineralization|regulation of cGMP biosynthetic process|positive regulation of actin filament polymerization|neuron projection development|extrinsic component of cytoplasmic side of plasma membrane|ubiquitin protein ligase binding|protein complex binding|regulation of inositol trisphosphate biosynthetic process|tumor necrosis factor-mediated signaling pathway|ionotropic glutamate receptor signaling pathway|response to immobilization stress|peptidyl-tyrosine autophosphorylation|interleukin-2-mediated signaling pathway|response to cocaine|response to hydrogen peroxide|activation of Janus kinase activity|neuronal cell body|negative regulation of apoptotic process|stress fiber assembly|dendritic spine|negative regulation of potassium ion transport|3-phosphoinositide-dependent protein kinase binding|positive regulation of JUN kinase activity|negative regulation of neuron apoptotic process|blood vessel endothelial cell migration|positive regulation of phosphatidylinositol 3-kinase activity|cell body|innate immune response|membrane raft|positive regulation of nitric oxide biosynthetic process|bone resorption|response to ethanol|negative regulation of myeloid cell differentiation|positive regulation of translation|positive regulation of angiogenesis|positive regulation of protein kinase activity|positive regulation of JNK cascade|protein autophosphorylation|vascular endothelial growth factor receptor signaling pathway|focal adhesion assembly|regulation of synaptic plasticity|perinuclear region of cytoplasm|positive regulation of peptidyl-tyrosine phosphorylation|regulation of calcium-mediated signaling|positive regulation of nitric-oxide synthase activity|regulation of release of sequestered calcium ion into cytosol|response to cAMP|response to calcium ion|positive regulation of synaptic transmission, glutamatergic|long-term synaptic potentiation|long term synaptic depression|chemokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|cellular response to retinoic acid|cellular response to fluid shear stress|activation of GTPase activity|apical dendrite|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of establishment of cell polarity|regulation of actin cytoskeleton reorganization|regulation of NMDA receptor activity|positive regulation of excitatory postsynaptic potential|positive regulation of B cell chemotaxis|positive regulation of DNA biosynthetic process hsa04020,hsa04062,hsa04072,hsa04650,hsa04670,hsa04912,hsa05161,hsa05163,hsa05170 Calcium signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Natural killer cell mediated cytotoxicity|Leukocyte transendothelial migration|GnRH signaling pathway|Hepatitis B|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection PTK6 2.42947464025265 0.980142803914724 3.87880647659057 3.95738912850095 1.98454893191584 0.424163265531873 1 0 0.0385814 0.0828231 0.0193308 GeneID:5753,Genbank:NM_001256358.1,HGNC:HGNC:9617,MIM:602004 protein tyrosine kinase 6 GO:0001726,GO:0004713,GO:0004715,GO:0005102,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0007169,GO:0007260,GO:0009968,GO:0010976,GO:0016477,GO:0016604,GO:0031234,GO:0038083,GO:0038128,GO:0042127,GO:0042531,GO:0042802,GO:0045087,GO:0045742,GO:0045787,GO:0045926,GO:0046777,GO:0060575,GO:0061099,GO:0071300 ruffle|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|receptor binding|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|tyrosine phosphorylation of STAT protein|negative regulation of signal transduction|positive regulation of neuron projection development|cell migration|nuclear body|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|ERBB2 signaling pathway|regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|identical protein binding|innate immune response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of cell cycle|negative regulation of growth|protein autophosphorylation|intestinal epithelial cell differentiation|negative regulation of protein tyrosine kinase activity|cellular response to retinoic acid PTK7 3772.22410406965 3665.52491976231 3878.92328837699 1.05821768322026 0.081636431042561 0.559009362119206 1 31.1278 32.1978 34.6078 34.0138 GeneID:5754,Genbank:NM_002821.4,HGNC:HGNC:9618,MIM:601890 protein tyrosine kinase 7 (inactive) PTMA 23277.5206144193 23636.8259040132 22918.2153248254 0.969597839316242 -0.0445416110220587 0.724586573682317 1 284.019 284.551 267.477 295.5 GeneID:5757,Genbank:NM_001099285.1,HGNC:HGNC:9623,MIM:188390 prothymosin alpha GO:0005634,GO:0008283,GO:0030154,GO:0033613,GO:0042393,GO:0043066,GO:0043154,GO:0043486,GO:0045944,GO:0051092,GO:0070062 nucleus|cell proliferation|cell differentiation|activating transcription factor binding|histone binding|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|histone exchange|positive regulation of transcription from RNA polymerase II promoter|positive regulation of NF-kappaB transcription factor activity|extracellular exosome PTMS 6997.77063056736 6275.28592593874 7720.25533519599 1.23026351728206 0.298967367887403 0.0385282560722091 0.750691665757301 153.466 176.38 197.552 208.687 GeneID:5763,Genbank:NM_001330333.1,HGNC:HGNC:9629,MIM:168440 parathymosin PTN 2918.03467252371 3034.40631694147 2801.66302810595 0.923298574902087 -0.115130835017381 0.409371773012906 1 39.1132 36.9556 36.8005 34.5392 GeneID:5764,Genbank:NM_001321387.2,HGNC:HGNC:9630,MIM:162095 pleiotrophin PTOV1 2909.7347132795 2758.16908672438 3061.30033983462 1.10990307105147 0.150433690071492 0.280620407443603 1 16.3288 17.706 19.2889 20.1936 GeneID:53635,Genbank:XM_011527034.3,HGNC:HGNC:9632,MIM:610195 prostate tumor overexpressed 1 GO:0005634,GO:0005886,GO:0006351,GO:0006355,GO:0048471 nucleus|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|perinuclear region of cytoplasm PTP4A1 3100.81127148835 3389.82440886756 2811.79813410913 0.829481942118787 -0.269717520938593 0.05116892241355 0.82804521131659 31.185 28.9668 25.7239 24.6623 GeneID:7803,Genbank:XM_017011270.1,HGNC:HGNC:9634,MIM:601585 protein tyrosine phosphatase type IVA, member 1 GO:0004725,GO:0005634,GO:0005737,GO:0005769,GO:0005783,GO:0005819,GO:0007049,GO:0007275,GO:0008138,GO:0009898,GO:0030335,GO:0070062 protein tyrosine phosphatase activity|nucleus|cytoplasm|early endosome|endoplasmic reticulum|spindle|cell cycle|multicellular organism development|protein tyrosine/serine/threonine phosphatase activity|cytoplasmic side of plasma membrane|positive regulation of cell migration|extracellular exosome PTP4A2 4507.00586816705 4633.72095687784 4380.29077945627 0.945307414973835 -0.0811445232932196 0.546586950361877 1 51.5947 53.0757 54.1432 46.069 GeneID:8073,Genbank:NM_080391.3,HGNC:HGNC:9635,MIM:601584 protein tyrosine phosphatase type IVA, member 2 GO:0004725,GO:0005634,GO:0005737,GO:0005769,GO:0005886,GO:0070062 protein tyrosine phosphatase activity|nucleus|cytoplasm|early endosome|plasma membrane|extracellular exosome PTP4A3 8.88577347637097 7.59120240278514 10.1803445499568 1.34107141527694 0.42338606626739 0.724008677831904 1 0.0852475 0.131498 0.173755 0.103282 GeneID:11156,Genbank:XM_017012998.2,HGNC:HGNC:9636,MIM:606449 protein tyrosine phosphatase type IVA, member 3 GO:0004727,GO:0005634,GO:0005737,GO:0005769,GO:0005886,GO:0006355,GO:0007219,GO:0008138,GO:0043117,GO:0043542,GO:1900746,GO:1901224,GO:1904951,GO:1990830 prenylated protein tyrosine phosphatase activity|nucleus|cytoplasm|early endosome|plasma membrane|regulation of transcription, DNA-templated|Notch signaling pathway|protein tyrosine/serine/threonine phosphatase activity|positive regulation of vascular permeability|endothelial cell migration|regulation of vascular endothelial growth factor signaling pathway|positive regulation of NIK/NF-kappaB signaling|positive regulation of establishment of protein localization|cellular response to leukemia inhibitory factor PTPA 5257.17012526166 4856.40852946778 5657.93172105555 1.16504443288168 0.220384977948777 0.103885737082091 1 31.8958 35.4949 40.3798 40.7529 GeneID:5524,Genbank:NM_021131.4,HGNC:HGNC:9308,MIM:600756 protein phosphatase 2 phosphatase activator GO:0000159,GO:0003755,GO:0005102,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0008160,GO:0016887,GO:0030472,GO:0032515,GO:0032516,GO:0034704,GO:0042803,GO:0043065,GO:0051721 protein phosphatase type 2A complex|peptidyl-prolyl cis-trans isomerase activity|receptor binding|ATP binding|nucleus|nucleoplasm|cytoplasm|protein tyrosine phosphatase activator activity|ATPase activity|mitotic spindle organization in nucleus|negative regulation of phosphoprotein phosphatase activity|positive regulation of phosphoprotein phosphatase activity|calcium channel complex|protein homodimerization activity|positive regulation of apoptotic process|protein phosphatase 2A binding hsa04931 Insulin resistance PTPDC1 152.660032595086 175.912964989913 129.40710020026 0.735631397081394 -0.44294503894532 0.0811606893815902 0.955084203626413 0.827267 0.760367 0.668908 0.471924 GeneID:138639,Genbank:XM_017014282.2,HGNC:HGNC:30184 protein tyrosine phosphatase domain containing 1 GO:0004725,GO:0005634,GO:0005654,GO:0005737,GO:0008138,GO:0060271 protein tyrosine phosphatase activity|nucleus|nucleoplasm|cytoplasm|protein tyrosine/serine/threonine phosphatase activity|cilium assembly PTPMT1 1189.74125751151 1207.72528281309 1171.75723220993 0.97021835088243 -0.0436186277060004 0.767389536698255 1 14.4278 15.6412 13.6977 15.2212 GeneID:114971,Genbank:NM_001143984.1,HGNC:HGNC:26965,MIM:609538 protein tyrosine phosphatase, mitochondrial 1 GO:0004439,GO:0004725,GO:0005634,GO:0005739,GO:0005743,GO:0008138,GO:0008962,GO:0032049 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein tyrosine phosphatase activity|nucleus|mitochondrion|mitochondrial inner membrane|protein tyrosine/serine/threonine phosphatase activity|phosphatidylglycerophosphatase activity|cardiolipin biosynthetic process PTPN1 2871.89684645411 3283.08322314196 2460.71046976627 0.749512060011484 -0.415976402866621 0.00643045668567193 0.317870969992968 32.9904 35.2749 23.6904 28.1426 GeneID:5770,Genbank:NM_002827.3,HGNC:HGNC:9642,MIM:176885 protein tyrosine phosphatase, non-receptor type 1 hsa04520,hsa04910,hsa04931 Adherens junction|Insulin signaling pathway|Insulin resistance PTPN11 2754.11961256928 2889.52747840572 2618.71174673283 0.90627681041389 -0.141976324950736 0.491947848969619 1 18.052 15.8332 17.6331 13.4173 GeneID:5781,Genbank:NM_001330437.1,HGNC:HGNC:9644,MIM:176876 protein tyrosine phosphatase, non-receptor type 11 hsa04014,hsa04072,hsa04360,hsa04625,hsa04630,hsa04650,hsa04670,hsa04722,hsa04920,hsa04931,hsa05120,hsa05168,hsa05205,hsa05211,hsa05220 Ras signaling pathway|Phospholipase D signaling pathway|Axon guidance|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Adipocytokine signaling pathway|Insulin resistance|Epithelial cell signaling in Helicobacter pylori infection|Herpes simplex infection|Proteoglycans in cancer|Renal cell carcinoma|Chronic myeloid leukemia PTPN12 2249.24300633984 2515.16029793757 1983.3257147421 0.788548434216471 -0.342728723945245 0.0596224251212178 0.879410748501007 20.8126 19.1238 18.5857 13.6308 GeneID:5782,Genbank:XM_006716073.4,HGNC:HGNC:9645,MIM:600079 protein tyrosine phosphatase, non-receptor type 12 GO:0002102,GO:0004721,GO:0004725,GO:0004726,GO:0005654,GO:0005737,GO:0005829,GO:0005925,GO:0006470,GO:0017124,GO:0035335,GO:0038128,GO:0042058,GO:0042246,GO:0042995,GO:0071345,GO:0071364,GO:1901185,GO:2000587 podosome|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|nucleoplasm|cytoplasm|cytosol|focal adhesion|protein dephosphorylation|SH3 domain binding|peptidyl-tyrosine dephosphorylation|ERBB2 signaling pathway|regulation of epidermal growth factor receptor signaling pathway|tissue regeneration|cell projection|cellular response to cytokine stimulus|cellular response to epidermal growth factor stimulus|negative regulation of ERBB signaling pathway|negative regulation of platelet-derived growth factor receptor-beta signaling pathway PTPN13 297.625814430902 301.522080367596 293.729548494209 0.974156015825153 -0.0377752494460733 0.93218957432282 1 1.13162 0.888197 1.16173 0.795762 GeneID:5783,Genbank:XM_011532165.2,HGNC:HGNC:9646,MIM:600267 protein tyrosine phosphatase, non-receptor type 13 hsa04210 Apoptosis PTPN14 1993.17923873919 1976.74772733096 2009.61075014742 1.01662479352428 0.0237873208865444 0.927436317788376 1 5.81221 5.85727 7.31773 4.76863 GeneID:5784,Genbank:NM_005401.4,HGNC:HGNC:9647,MIM:603155 protein tyrosine phosphatase, non-receptor type 14 PTPN18 561.858849802235 534.408806499257 589.308893105213 1.10273050507081 0.141080255568397 0.423439204139557 1 4.49705 4.95617 5.40786 5.08487 GeneID:26469,Genbank:NM_014369.3,HGNC:HGNC:9649,MIM:606587 protein tyrosine phosphatase, non-receptor type 18 GO:0004725,GO:0004726,GO:0005654,GO:0005829,GO:0006470,GO:0038128,GO:0071345,GO:1901185 protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|nucleoplasm|cytosol|protein dephosphorylation|ERBB2 signaling pathway|cellular response to cytokine stimulus|negative regulation of ERBB signaling pathway PTPN2 311.962837432741 335.077258419013 288.848416446468 0.862035274519477 -0.214181189223699 0.291589751105217 1 1.80431 1.49823 1.69655 1.53559 GeneID:5771,Genbank:NM_080423.2,HGNC:HGNC:9650,MIM:176887 protein tyrosine phosphatase, non-receptor type 2 GO:0000122,GO:0004725,GO:0004726,GO:0005178,GO:0005634,GO:0005654,GO:0005783,GO:0005793,GO:0005829,GO:0005886,GO:0008285,GO:0008286,GO:0010804,GO:0010888,GO:0019901,GO:0019905,GO:0030183,GO:0030217,GO:0030218,GO:0030971,GO:0035335,GO:0042059,GO:0042532,GO:0042593,GO:0045650,GO:0045722,GO:0046627,GO:0050728,GO:0050860,GO:0050922,GO:0060334,GO:0060336,GO:0060339,GO:0061099,GO:0070104,GO:0070373,GO:0071345,GO:0097677,GO:1902202,GO:1902206,GO:1902215,GO:1902227,GO:1902233,GO:1902237,GO:1903899,GO:2000587 negative regulation of transcription from RNA polymerase II promoter|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|integrin binding|nucleus|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|negative regulation of cell proliferation|insulin receptor signaling pathway|negative regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of lipid storage|protein kinase binding|syntaxin binding|B cell differentiation|T cell differentiation|erythrocyte differentiation|receptor tyrosine kinase binding|peptidyl-tyrosine dephosphorylation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of tyrosine phosphorylation of STAT protein|glucose homeostasis|negative regulation of macrophage differentiation|positive regulation of gluconeogenesis|negative regulation of insulin receptor signaling pathway|negative regulation of inflammatory response|negative regulation of T cell receptor signaling pathway|negative regulation of chemotaxis|regulation of interferon-gamma-mediated signaling pathway|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of type I interferon-mediated signaling pathway|negative regulation of protein tyrosine kinase activity|negative regulation of interleukin-6-mediated signaling pathway|negative regulation of ERK1 and ERK2 cascade|cellular response to cytokine stimulus|STAT family protein binding|regulation of hepatocyte growth factor receptor signaling pathway|negative regulation of interleukin-2-mediated signaling pathway|negative regulation of interleukin-4-mediated signaling pathway|negative regulation of macrophage colony-stimulating factor signaling pathway|negative regulation of positive thymic T cell selection|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of PERK-mediated unfolded protein response|negative regulation of platelet-derived growth factor receptor-beta signaling pathway hsa04630 Jak-STAT signaling pathway PTPN21 447.715239420769 472.813697331792 422.616781509746 0.893833626002546 -0.161921774975881 0.37617416406004 1 2.50498 2.28897 2.31038 1.97935 GeneID:11099,Genbank:NM_007039.3,HGNC:HGNC:9651,MIM:603271 protein tyrosine phosphatase, non-receptor type 21 PTPN22 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0 0 0.00697724 0.00648253 GeneID:26191,Genbank:XM_011541225.2,HGNC:HGNC:9652,MIM:600716 protein tyrosine phosphatase, non-receptor type 22 GO:0004725,GO:0005634,GO:0005737,GO:0005829,GO:0006470,GO:0006914,GO:0009898,GO:0010507,GO:0010628,GO:0010629,GO:0016791,GO:0017124,GO:0019900,GO:0030217,GO:0031625,GO:0031663,GO:0032481,GO:0032496,GO:0032720,GO:0032817,GO:0034141,GO:0034145,GO:0035644,GO:0043508,GO:0045088,GO:0048471,GO:0050852,GO:0050855,GO:0050860,GO:0050868,GO:0070374,GO:0070433,GO:0071225,GO:1900165,GO:1901222,GO:1902523,GO:1902715,GO:1903753,GO:2000483 protein tyrosine phosphatase activity|nucleus|cytoplasm|cytosol|protein dephosphorylation|autophagy|cytoplasmic side of plasma membrane|negative regulation of autophagy|positive regulation of gene expression|negative regulation of gene expression|phosphatase activity|SH3 domain binding|kinase binding|T cell differentiation|ubiquitin protein ligase binding|lipopolysaccharide-mediated signaling pathway|positive regulation of type I interferon production|response to lipopolysaccharide|negative regulation of tumor necrosis factor production|regulation of natural killer cell proliferation|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|phosphoanandamide dephosphorylation|negative regulation of JUN kinase activity|regulation of innate immune response|perinuclear region of cytoplasm|T cell receptor signaling pathway|regulation of B cell receptor signaling pathway|negative regulation of T cell receptor signaling pathway|negative regulation of T cell activation|positive regulation of ERK1 and ERK2 cascade|negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway|cellular response to muramyl dipeptide|negative regulation of interleukin-6 secretion|regulation of NIK/NF-kappaB signaling|positive regulation of protein K63-linked ubiquitination|positive regulation of interferon-gamma secretion|negative regulation of p38MAPK cascade|negative regulation of interleukin-8 secretion PTPN23 1632.85552637402 1580.19204660492 1685.51900614313 1.06665453086193 0.0930929902993848 0.522539626339425 1 11.7305 11.3041 12.8093 12.5133 GeneID:25930,Genbank:NM_015466.3,HGNC:HGNC:14406,MIM:606584 protein tyrosine phosphatase, non-receptor type 23 GO:0004725,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0010633,GO:0015031,GO:0016604,GO:0019901,GO:0032456,GO:0036064,GO:0043162,GO:0045022,GO:0060271,GO:0061357,GO:0070062,GO:0071345,GO:1903387,GO:1903393,GO:2000643 protein tyrosine phosphatase activity|nucleus|nucleoplasm|cytoplasm|endosome|early endosome|cytosol|negative regulation of epithelial cell migration|protein transport|nuclear body|protein kinase binding|endocytic recycling|ciliary basal body|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|early endosome to late endosome transport|cilium assembly|positive regulation of Wnt protein secretion|extracellular exosome|cellular response to cytokine stimulus|positive regulation of homophilic cell adhesion|positive regulation of adherens junction organization|positive regulation of early endosome to late endosome transport PTPN3 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.0035802 0 GeneID:5774,Genbank:NM_001145368.1,HGNC:HGNC:9655,MIM:176877 protein tyrosine phosphatase, non-receptor type 3 GO:0001784,GO:0004725,GO:0005737,GO:0005856,GO:0005886,GO:0006470,GO:0008092,GO:0009898,GO:0017080,GO:0042059,GO:0045930,GO:0051045,GO:0051117,GO:0097421,GO:0098902,GO:2000649 phosphotyrosine residue binding|protein tyrosine phosphatase activity|cytoplasm|cytoskeleton|plasma membrane|protein dephosphorylation|cytoskeletal protein binding|cytoplasmic side of plasma membrane|sodium channel regulator activity|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of mitotic cell cycle|negative regulation of membrane protein ectodomain proteolysis|ATPase binding|liver regeneration|regulation of membrane depolarization during action potential|regulation of sodium ion transmembrane transporter activity PTPN4 112.498425457758 96.0617694370414 128.935081478474 1.34221014493156 0.424610566706421 0.201853730017287 1 0.256317 0.25761 0.42008 0.273787 GeneID:5775,Genbank:NM_002830.3,HGNC:HGNC:9656,MIM:176878 protein tyrosine phosphatase, non-receptor type 4 GO:0004726,GO:0005654,GO:0005737,GO:0005856,GO:0006470,GO:0008092,GO:0009898,GO:0071345 non-membrane spanning protein tyrosine phosphatase activity|nucleoplasm|cytoplasm|cytoskeleton|protein dephosphorylation|cytoskeletal protein binding|cytoplasmic side of plasma membrane|cellular response to cytokine stimulus PTPN5 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00658999 0 0 GeneID:84867,Genbank:NM_001278236.1,HGNC:HGNC:9657,MIM:176879 protein tyrosine phosphatase, non-receptor type 5 GO:0001784,GO:0004725,GO:0005654,GO:0005789,GO:0006470,GO:0016021,GO:0071345 phosphotyrosine residue binding|protein tyrosine phosphatase activity|nucleoplasm|endoplasmic reticulum membrane|protein dephosphorylation|integral component of membrane|cellular response to cytokine stimulus hsa04010 MAPK signaling pathway PTPN6 1.02273099320278 1.07619535328461 0.969266633120943 0.900641904987498 -0.150974490057726 1 1 0.015902 0 0.0147984 0 GeneID:5777,Genbank:NM_080548.4,HGNC:HGNC:9658,MIM:176883 protein tyrosine phosphatase, non-receptor type 6 hsa04520,hsa04630,hsa04650,hsa04660,hsa04662,hsa05140,hsa05205 Adherens junction|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Leishmaniasis|Proteoglycans in cancer PTPN7 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0150183 GeneID:5778,Genbank:XM_017001937.1,HGNC:HGNC:9659,MIM:176889 protein tyrosine phosphatase, non-receptor type 7 hsa04010 MAPK signaling pathway PTPN9 1516.52518478722 1492.93092809204 1540.1194414824 1.03160796826057 0.044894821827994 0.748735833862122 1 15.408 14.7747 15.6774 15.5259 GeneID:5780,Genbank:NM_002833.3,HGNC:HGNC:9661,MIM:600768 protein tyrosine phosphatase, non-receptor type 9 GO:0004725,GO:0004726,GO:0005654,GO:0005737,GO:0006470,GO:0071345 protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity|nucleoplasm|cytoplasm|protein dephosphorylation|cellular response to cytokine stimulus PTPRA 1789.38053410642 1711.46150474288 1867.29956346995 1.09105554422066 0.125724549261809 0.38115441147392 1 12.9979 13.556 15.1562 14.6247 GeneID:5786,Genbank:NM_002836.3,HGNC:HGNC:9664,MIM:176884 protein tyrosine phosphatase, receptor type A GO:0000165,GO:0004725,GO:0005001,GO:0005088,GO:0005622,GO:0005886,GO:0005887,GO:0007411,GO:0008286,GO:0043235,GO:0070062 MAPK cascade|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|Ras guanyl-nucleotide exchange factor activity|intracellular|plasma membrane|integral component of plasma membrane|axon guidance|insulin receptor signaling pathway|receptor complex|extracellular exosome PTPRB 1560.69365930155 1415.50066358363 1705.88665501947 1.20514719555176 0.269209366640646 0.0590003765669282 0.879410748501007 3.51477 3.29002 4.22109 4.05391 GeneID:5787,Genbank:NM_001330204.1,HGNC:HGNC:9665,MIM:176882 protein tyrosine phosphatase, receptor type B GO:0001525,GO:0005001,GO:0005886,GO:0005887,GO:0006470,GO:0006796,GO:0016311,GO:0035579,GO:0043235,GO:0043312,GO:0070821 angiogenesis|transmembrane receptor protein tyrosine phosphatase activity|plasma membrane|integral component of plasma membrane|protein dephosphorylation|phosphate-containing compound metabolic process|dephosphorylation|specific granule membrane|receptor complex|neutrophil degranulation|tertiary granule membrane hsa04520 Adherens junction PTPRCAP 6.3956564465328 4.55472144167109 8.23659145139452 1.80836337784306 0.854684606258141 0.50990998282058 1 0.174025 0.291727 0.239844 0.522844 GeneID:5790,Genbank:NM_005608.2,HGNC:HGNC:9667,MIM:601577 protein tyrosine phosphatase, receptor type C associated protein GO:0005886,GO:0006952,GO:0016021 plasma membrane|defense response|integral component of membrane PTPRD 90.1100283897772 78.9190790236417 101.300977755913 1.28360567570189 0.360202073891655 0.239945148395281 1 0.223796 0.167796 0.284069 0.1789 GeneID:5789,Genbank:XM_017014958.2,HGNC:HGNC:9668,MIM:601598 protein tyrosine phosphatase, receptor type D PTPRE 356.205390233194 383.805032620893 328.605747845495 0.856178840599201 -0.224015913335023 0.24500190364853 1 1.14609 1.1413 1.09321 0.890474 GeneID:5791,Genbank:XM_024448092.1,HGNC:HGNC:9669,MIM:600926 protein tyrosine phosphatase, receptor type E GO:0005001,GO:0005634,GO:0005737,GO:0005886,GO:0006470,GO:0016021,GO:0046627 transmembrane receptor protein tyrosine phosphatase activity|nucleus|cytoplasm|plasma membrane|protein dephosphorylation|integral component of membrane|negative regulation of insulin receptor signaling pathway PTPRF 5197.3794527844 5164.62486232595 5230.13404324285 1.01268420895286 0.0181843605113027 0.901115289254998 1 21.1451 20.898 22.3945 21.2159 GeneID:5792,Genbank:XM_011541873.2,HGNC:HGNC:9670,MIM:179590 protein tyrosine phosphatase, receptor type F GO:0004725,GO:0005001,GO:0005886,GO:0005887,GO:0007155,GO:0007185,GO:0008201,GO:0016477,GO:0031102,GO:0032403,GO:0035335,GO:0035373,GO:0043005,GO:0043025,GO:0048679,GO:0070062,GO:1900121 protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|plasma membrane|integral component of plasma membrane|cell adhesion|transmembrane receptor protein tyrosine phosphatase signaling pathway|heparin binding|cell migration|neuron projection regeneration|protein complex binding|peptidyl-tyrosine dephosphorylation|chondroitin sulfate proteoglycan binding|neuron projection|neuronal cell body|regulation of axon regeneration|extracellular exosome|negative regulation of receptor binding hsa04514,hsa04520,hsa04910,hsa04931 Cell adhesion molecules (CAMs)|Adherens junction|Insulin signaling pathway|Insulin resistance PTPRG 848.525827566976 860.903894055607 836.147761078345 0.971244022534688 -0.0420942803231022 0.906206476389997 1 3.36727 2.95473 3.90496 2.36233 GeneID:5793,Genbank:NM_002841.3,HGNC:HGNC:9671,MIM:176886 protein tyrosine phosphatase, receptor type G PTPRH 40.7045953404073 47.007619967475 34.4015707133396 0.731829663725633 -0.450420200332909 0.313017861579989 1 0.253784 0.224508 0.142192 0.189952 GeneID:5794,Genbank:NM_001161440.2,HGNC:HGNC:9672,MIM:602510 protein tyrosine phosphatase, receptor type H GO:0005001,GO:0005737,GO:0005887,GO:0006470,GO:0006915,GO:0016324,GO:0031528 transmembrane receptor protein tyrosine phosphatase activity|cytoplasm|integral component of plasma membrane|protein dephosphorylation|apoptotic process|apical plasma membrane|microvillus membrane PTPRJ 1954.89144136097 1676.3028593175 2233.48002340443 1.33238454554315 0.414010525263028 0.0976227334062853 1 6.32845 7.05245 10.6758 7.40505 GeneID:5795,Genbank:XM_017018085.1,HGNC:HGNC:9673,MIM:600925 protein tyrosine phosphatase, receptor type J hsa04520 Adherens junction PTPRK 1617.20127350374 1626.65851789319 1607.7440291143 0.988372182255323 -0.0168736883152152 0.964506442880563 1 6.06206 5.29454 6.76115 4.67383 GeneID:5796,Genbank:NM_001291984.1,HGNC:HGNC:9674,MIM:602545 protein tyrosine phosphatase, receptor type K GO:0001750,GO:0004725,GO:0005001,GO:0005886,GO:0005887,GO:0005911,GO:0005912,GO:0006470,GO:0007155,GO:0007165,GO:0007179,GO:0008013,GO:0008285,GO:0009986,GO:0010839,GO:0016021,GO:0016477,GO:0019901,GO:0030054,GO:0030336,GO:0030424,GO:0030425,GO:0031175,GO:0031256,GO:0034394,GO:0034614,GO:0034644,GO:0043025,GO:0043231,GO:0045295,GO:0045786,GO:0045892,GO:0048041 photoreceptor outer segment|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|plasma membrane|integral component of plasma membrane|cell-cell junction|adherens junction|protein dephosphorylation|cell adhesion|signal transduction|transforming growth factor beta receptor signaling pathway|beta-catenin binding|negative regulation of cell proliferation|cell surface|negative regulation of keratinocyte proliferation|integral component of membrane|cell migration|protein kinase binding|cell junction|negative regulation of cell migration|axon|dendrite|neuron projection development|leading edge membrane|protein localization to cell surface|cellular response to reactive oxygen species|cellular response to UV|neuronal cell body|intracellular membrane-bounded organelle|gamma-catenin binding|negative regulation of cell cycle|negative regulation of transcription, DNA-templated|focal adhesion assembly PTPRM 0.975139704544532 0.980142803914724 0.97013660517434 0.989791080748215 -0.0148040531050533 1 1 0 0.00480903 0.00992253 0 GeneID:5797,Genbank:NM_001105244.1,HGNC:HGNC:9675,MIM:176888 protein tyrosine phosphatase, receptor type M GO:0001937,GO:0004725,GO:0005001,GO:0005737,GO:0005886,GO:0005887,GO:0005911,GO:0005913,GO:0006470,GO:0007156,GO:0007165,GO:0010596,GO:0010842,GO:0016525,GO:0030027,GO:0031175,GO:0031290,GO:0042493,GO:0042802,GO:0045296,GO:0048471 negative regulation of endothelial cell proliferation|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|cytoplasm|plasma membrane|integral component of plasma membrane|cell-cell junction|cell-cell adherens junction|protein dephosphorylation|homophilic cell adhesion via plasma membrane adhesion molecules|signal transduction|negative regulation of endothelial cell migration|retina layer formation|negative regulation of angiogenesis|lamellipodium|neuron projection development|retinal ganglion cell axon guidance|response to drug|identical protein binding|cadherin binding|perinuclear region of cytoplasm hsa04514,hsa04520 Cell adhesion molecules (CAMs)|Adherens junction PTPRN2 244.390838295197 239.188993771351 249.592682819043 1.04349568466197 0.0614246342977972 0.790186067401525 1 0.405426 0.410158 0.45103 0.408349 GeneID:5799,Genbank:NM_130842.3,HGNC:HGNC:9677,MIM:601698 protein tyrosine phosphatase, receptor type N2 GO:0005001,GO:0005788,GO:0005886,GO:0005887,GO:0006470,GO:0006629,GO:0007269,GO:0030054,GO:0030667,GO:0030672,GO:0034260,GO:0035773,GO:0043195,GO:0043235,GO:0043312,GO:0101003 transmembrane receptor protein tyrosine phosphatase activity|endoplasmic reticulum lumen|plasma membrane|integral component of plasma membrane|protein dephosphorylation|lipid metabolic process|neurotransmitter secretion|cell junction|secretory granule membrane|synaptic vesicle membrane|negative regulation of GTPase activity|insulin secretion involved in cellular response to glucose stimulus|terminal bouton|receptor complex|neutrophil degranulation|ficolin-1-rich granule membrane hsa04940 Type I diabetes mellitus PTPRO 16.9044370996858 22.1776746019202 11.6311995974513 0.524455327541159 -0.931108203838087 0.188582145712153 1 0.0430826 0.0388225 0.0292914 0.0249922 GeneID:5800,Genbank:NM_030667.2,HGNC:HGNC:9678,MIM:600579 protein tyrosine phosphatase, receptor type O GO:0000902,GO:0002548,GO:0003093,GO:0003105,GO:0004725,GO:0005001,GO:0005886,GO:0005887,GO:0006470,GO:0007411,GO:0010812,GO:0010977,GO:0016021,GO:0016324,GO:0016328,GO:0016791,GO:0017147,GO:0030027,GO:0030032,GO:0030424,GO:0030426,GO:0032835,GO:0035335,GO:0036060,GO:0042803,GO:0043005,GO:0043197,GO:0070062,GO:0072112,GO:0090090,GO:0090260 cell morphogenesis|monocyte chemotaxis|regulation of glomerular filtration|negative regulation of glomerular filtration|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|plasma membrane|integral component of plasma membrane|protein dephosphorylation|axon guidance|negative regulation of cell-substrate adhesion|negative regulation of neuron projection development|integral component of membrane|apical plasma membrane|lateral plasma membrane|phosphatase activity|Wnt-protein binding|lamellipodium|lamellipodium assembly|axon|growth cone|glomerulus development|peptidyl-tyrosine dephosphorylation|slit diaphragm assembly|protein homodimerization activity|neuron projection|dendritic spine|extracellular exosome|glomerular visceral epithelial cell differentiation|negative regulation of canonical Wnt signaling pathway|negative regulation of retinal ganglion cell axon guidance PTPRQ 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00383625 0 GeneID:374462,Genbank:XM_017019274.1,HGNC:HGNC:9679,MIM:603317 protein tyrosine phosphatase, receptor type Q GO:0004725,GO:0016021,GO:0045598 protein tyrosine phosphatase activity|integral component of membrane|regulation of fat cell differentiation PTPRR 347.727220822101 350.423359358854 345.031082285347 0.984612107242584 -0.0223726151648312 0.916605782001524 1 2.78246 2.85129 2.62137 2.8617 GeneID:5801,Genbank:NM_002849.3,HGNC:HGNC:9680,MIM:602853 protein tyrosine phosphatase, receptor type R GO:0001701,GO:0004725,GO:0005001,GO:0005615,GO:0005829,GO:0005886,GO:0006470,GO:0010633,GO:0016021,GO:0019901,GO:0030054,GO:0038128,GO:0048471,GO:0070373 in utero embryonic development|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|extracellular space|cytosol|plasma membrane|protein dephosphorylation|negative regulation of epithelial cell migration|integral component of membrane|protein kinase binding|cell junction|ERBB2 signaling pathway|perinuclear region of cytoplasm|negative regulation of ERK1 and ERK2 cascade hsa04010 MAPK signaling pathway PTPRS 4299.0070679453 4245.60540219212 4352.40873369849 1.0251562077463 0.0358437565312012 0.806147854943665 1 18.5699 18.6813 19.5707 19.151 GeneID:5802,Genbank:XM_017027066.1,HGNC:HGNC:9681,MIM:601576 protein tyrosine phosphatase, receptor type S GO:0004721,GO:0004725,GO:0005886,GO:0005887,GO:0006470,GO:0007155,GO:0008201,GO:0010977,GO:0021510,GO:0021549,GO:0021766,GO:0021987,GO:0022038,GO:0030054,GO:0030285,GO:0030424,GO:0030517,GO:0032687,GO:0032688,GO:0034164,GO:0035335,GO:0035374,GO:0043204,GO:0043395,GO:0048671,GO:0048681,GO:0061000,GO:0070062,GO:0090557,GO:0099061 phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|plasma membrane|integral component of plasma membrane|protein dephosphorylation|cell adhesion|heparin binding|negative regulation of neuron projection development|spinal cord development|cerebellum development|hippocampus development|cerebral cortex development|corpus callosum development|cell junction|integral component of synaptic vesicle membrane|axon|negative regulation of axon extension|negative regulation of interferon-alpha production|negative regulation of interferon-beta production|negative regulation of toll-like receptor 9 signaling pathway|peptidyl-tyrosine dephosphorylation|chondroitin sulfate binding|perikaryon|heparan sulfate proteoglycan binding|negative regulation of collateral sprouting|negative regulation of axon regeneration|negative regulation of dendritic spine development|extracellular exosome|establishment of endothelial intestinal barrier|integral component of postsynaptic density membrane PTPRT 22.1195793889305 22.4276146304529 21.8115441474081 0.972530717457207 -0.0401842764355116 0.975908288774926 1 0.030226 0.049282 0.0419585 0.0247119 GeneID:11122,Genbank:XM_024451820.1,HGNC:HGNC:9682,MIM:608712 protein tyrosine phosphatase, receptor type T GO:0004725,GO:0005886,GO:0006470,GO:0007155,GO:0007156,GO:0007165,GO:0007169,GO:0008013,GO:0009986,GO:0016021,GO:0045294,GO:0045295,GO:0045296,GO:0070097 protein tyrosine phosphatase activity|plasma membrane|protein dephosphorylation|cell adhesion|homophilic cell adhesion via plasma membrane adhesion molecules|signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|beta-catenin binding|cell surface|integral component of membrane|alpha-catenin binding|gamma-catenin binding|cadherin binding|delta-catenin binding PTPRU 157.867125091364 170.839763181815 144.894487000914 0.848130928668581 -0.237641099485284 0.333681446757712 1 1.04918 1.09528 0.863252 0.998761 GeneID:10076,Genbank:NM_005704.4,HGNC:HGNC:9683,MIM:602454 protein tyrosine phosphatase, receptor type U GO:0004725,GO:0005001,GO:0005886,GO:0005887,GO:0005911,GO:0006470,GO:0007155,GO:0007185,GO:0008013,GO:0008285,GO:0030154,GO:0030336,GO:0031100,GO:0034109,GO:0034394,GO:0051384,GO:0060070,GO:0098609 protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|plasma membrane|integral component of plasma membrane|cell-cell junction|protein dephosphorylation|cell adhesion|transmembrane receptor protein tyrosine phosphatase signaling pathway|beta-catenin binding|negative regulation of cell proliferation|cell differentiation|negative regulation of cell migration|animal organ regeneration|homotypic cell-cell adhesion|protein localization to cell surface|response to glucocorticoid|canonical Wnt signaling pathway|cell-cell adhesion PTPRZ1 312.427830885101 209.958214443288 414.897447326914 1.97609533128785 0.982652547458368 0.000330436157595041 0.0485528944957998 0.83081 0.884021 2.01306 1.36946 GeneID:5803,Genbank:NM_002851.2,HGNC:HGNC:9685,MIM:176891 protein tyrosine phosphatase, receptor type Z1 GO:0002244,GO:0004725,GO:0005001,GO:0005578,GO:0005886,GO:0005887,GO:0006470,GO:0007409,GO:0007417,GO:0007611,GO:0019221,GO:0031226,GO:0035335,GO:0048709,GO:0070445,GO:0072534 hematopoietic progenitor cell differentiation|protein tyrosine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity|proteinaceous extracellular matrix|plasma membrane|integral component of plasma membrane|protein dephosphorylation|axonogenesis|central nervous system development|learning or memory|cytokine-mediated signaling pathway|intrinsic component of plasma membrane|peptidyl-tyrosine dephosphorylation|oligodendrocyte differentiation|regulation of oligodendrocyte progenitor proliferation|perineuronal net hsa05120 Epithelial cell signaling in Helicobacter pylori infection PTRH1 99.3916087048025 97.9838374252938 100.799379984311 1.02873476517149 0.0408710655200108 0.929095065949403 1 3.81012 3.89829 4.04301 4.09959 GeneID:138428,Genbank:NM_001345980.1,HGNC:HGNC:27039 peptidyl-tRNA hydrolase 1 homolog GO:0003723,GO:0004045,GO:0005739 RNA binding|aminoacyl-tRNA hydrolase activity|mitochondrion PTRH2 641.932657180999 721.70806659292 562.157247769079 0.77892609739412 -0.360441639489664 0.0290283870831505 0.674846840672015 9.61107 9.73091 7.46445 7.66027 GeneID:51651,Genbank:XM_011524887.2,HGNC:HGNC:24265,MIM:608625 peptidyl-tRNA hydrolase 2 GO:0004045,GO:0005739,GO:0005829,GO:0006915,GO:0010629,GO:0016020,GO:2000210,GO:2000811 aminoacyl-tRNA hydrolase activity|mitochondrion|cytosol|apoptotic process|negative regulation of gene expression|membrane|positive regulation of anoikis|negative regulation of anoikis PTRHD1 397.189854480195 376.166820944278 418.212888016112 1.11177505492453 0.152864917581772 0.433450903578231 1 29.3763 33.9633 36.0331 38.472 GeneID:391356,Genbank:NM_001013663.1,HGNC:HGNC:33782,MIM:617342 peptidyl-tRNA hydrolase domain containing 1 GO:0004045,GO:0070062 aminoacyl-tRNA hydrolase activity|extracellular exosome PTS 686.997775323647 681.965273760543 692.030276886751 1.01475882059318 0.0211368804354346 0.909539891168908 1 31.2447 35.1052 35.0144 34.6141 GeneID:5805,Genbank:NM_000317.2,HGNC:HGNC:9689,MIM:612719 6-pyruvoyltetrahydropterin synthase GO:0003874,GO:0005737,GO:0005739,GO:0005829,GO:0006520,GO:0006729,GO:0007417,GO:0042802,GO:0042803,GO:0046872,GO:0051186 6-pyruvoyltetrahydropterin synthase activity|cytoplasm|mitochondrion|cytosol|cellular amino acid metabolic process|tetrahydrobiopterin biosynthetic process|central nervous system development|identical protein binding|protein homodimerization activity|metal ion binding|cofactor metabolic process hsa00790 Folate biosynthesis PTTG1 3782.5791000693 3964.1633896471 3600.99481049151 0.908387081091548 -0.138620906431388 0.302892837136301 1 75.0072 79.6986 67.6936 78.4208 GeneID:9232,Genbank:NM_004219.3,HGNC:HGNC:9690,MIM:604147 pituitary tumor-transforming 1 hsa04110,hsa04114,hsa05166 Cell cycle|Oocyte meiosis|Human T-cell leukemia virus 1 infection PTTG1IP 5742.4792172562 5643.33024213719 5841.62819237522 1.03513846288091 0.0498237593679223 0.718254681705207 1 101.017 105.868 109.72 107.477 GeneID:754,Genbank:NM_001286822.1,HGNC:HGNC:13524,MIM:603784 PTTG1 interacting protein PTTG2 0.968831647094244 0 1.93766329418849 Inf Inf 0.451925900856321 1 0 0 0.0787672 0.220684 GeneID:10744,Genbank:NM_006607.2,HGNC:HGNC:9691,MIM:604231 pituitary tumor-transforming 2 GO:0005634,GO:0005737,GO:0006355,GO:0017124,GO:0030414,GO:0045143,GO:0051276,GO:2000816 nucleus|cytoplasm|regulation of transcription, DNA-templated|SH3 domain binding|peptidase inhibitor activity|homologous chromosome segregation|chromosome organization|negative regulation of mitotic sister chromatid separation hsa04110,hsa04114,hsa05166 Cell cycle|Oocyte meiosis|Human T-cell leukemia virus 1 infection PTX3 91.9340904631387 89.8545373458664 94.0136435804111 1.0462871031046 0.0652787840811378 0.867512195104368 1 1.82084 2.28545 2.11217 2.22185 GeneID:5806,Genbank:NM_002852.3,HGNC:HGNC:9692,MIM:602492 pentraxin 3 GO:0001849,GO:0001872,GO:0001878,GO:0005576,GO:0005615,GO:0006954,GO:0008228,GO:0035580,GO:0042802,GO:0043312,GO:0044869,GO:0044871,GO:0045087,GO:0045429,GO:0046597,GO:0046790,GO:0050766,GO:1903016,GO:1903019,GO:1904724 complement component C1q binding|(1->3)-beta-D-glucan binding|response to yeast|extracellular region|extracellular space|inflammatory response|opsonization|specific granule lumen|identical protein binding|neutrophil degranulation|negative regulation by host of viral exo-alpha-sialidase activity|negative regulation by host of viral glycoprotein metabolic process|innate immune response|positive regulation of nitric oxide biosynthetic process|negative regulation of viral entry into host cell|virion binding|positive regulation of phagocytosis|negative regulation of exo-alpha-sialidase activity|negative regulation of glycoprotein metabolic process|tertiary granule lumen PTX4 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0569771 0 0 GeneID:390667,Genbank:NM_001328608.1,HGNC:HGNC:14171,MIM:613442 pentraxin 4 GO:0005576,GO:0046872 extracellular region|metal ion binding PUDP 311.954265268 331.666375915528 292.242154620472 0.88113289691718 -0.18256846477253 0.361367849045638 1 5.43814 4.82541 4.76846 4.35823 GeneID:8226,Genbank:NM_001178136.1,HGNC:HGNC:16818,MIM:306480 pseudouridine 5'-phosphatase GO:0005737,GO:0005829,GO:0009117,GO:0016787,GO:0016791,GO:0043097,GO:0046872,GO:0070062,GO:1990738 cytoplasm|cytosol|nucleotide metabolic process|hydrolase activity|phosphatase activity|pyrimidine nucleoside salvage|metal ion binding|extracellular exosome|pseudouridine 5'-phosphatase activity PUF60 3272.34029446465 3309.06885010251 3235.61173882678 0.977801274436022 -0.0323868091758682 0.83425262315154 1 20.4453 22.7358 19.4973 22.7364 GeneID:22827,Genbank:NM_001271097.1,HGNC:HGNC:17042,MIM:604819 poly(U) binding splicing factor 60 GO:0000398,GO:0003677,GO:0003723,GO:0005654,GO:0006351,GO:0006355,GO:0006915,GO:0030054,GO:0030529,GO:0042802,GO:0045296 mRNA splicing, via spliceosome|DNA binding|RNA binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|cell junction|intracellular ribonucleoprotein complex|identical protein binding|cadherin binding hsa03040 Spliceosome PUM1 1876.19231264278 1909.63737122812 1842.74725405743 0.964972345965521 -0.0514404964549027 0.748397191940673 1 12.9528 12.3482 14.3385 10.8486 GeneID:9698,Genbank:NM_014676.2,HGNC:HGNC:14957,MIM:607204 pumilio RNA binding family member 1 GO:0000932,GO:0003723,GO:0003730,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007283,GO:0008344,GO:0010494,GO:0010608,GO:0016441,GO:0016607,GO:0035196,GO:0035198,GO:0043488,GO:0048863,GO:0051726,GO:0051983,GO:0061157,GO:1900246,GO:2000637 P-body|RNA binding|mRNA 3'-UTR binding|nucleus|nucleoplasm|cytoplasm|cytosol|spermatogenesis|adult locomotory behavior|cytoplasmic stress granule|posttranscriptional regulation of gene expression|posttranscriptional gene silencing|nuclear speck|production of miRNAs involved in gene silencing by miRNA|miRNA binding|regulation of mRNA stability|stem cell differentiation|regulation of cell cycle|regulation of chromosome segregation|mRNA destabilization|positive regulation of RIG-I signaling pathway|positive regulation of gene silencing by miRNA PUM2 1385.02480482058 1503.07631470738 1266.97329493378 0.842920138210302 -0.246532144225123 0.269172800490448 1 3.82843 3.47358 3.54465 2.56965 GeneID:23369,Genbank:NM_001352925.1,HGNC:HGNC:14958,MIM:607205 pumilio RNA binding family member 2 GO:0003723,GO:0003730,GO:0005829,GO:0010494,GO:0010608,GO:0031965,GO:0034063,GO:0035196,GO:0035198,GO:0043488,GO:0048471,GO:0051983,GO:0060964,GO:1900246,GO:2000637 RNA binding|mRNA 3'-UTR binding|cytosol|cytoplasmic stress granule|posttranscriptional regulation of gene expression|nuclear membrane|stress granule assembly|production of miRNAs involved in gene silencing by miRNA|miRNA binding|regulation of mRNA stability|perinuclear region of cytoplasm|regulation of chromosome segregation|regulation of gene silencing by miRNA|positive regulation of RIG-I signaling pathway|positive regulation of gene silencing by miRNA PUM3 475.274751166507 529.391405619243 421.158096713771 0.79555144311633 -0.329972871648187 0.0663071040103443 0.908334826576206 7.02239 6.08771 5.53504 4.98272 GeneID:9933,Genbank:NM_014878.4,HGNC:HGNC:29676,MIM:609960 pumilio RNA binding family member 3 GO:0003677,GO:0003723,GO:0003729,GO:0005654,GO:0005694,GO:0005730,GO:0005783,GO:0006417,GO:0010835 DNA binding|RNA binding|mRNA binding|nucleoplasm|chromosome|nucleolus|endoplasmic reticulum|regulation of translation|regulation of protein ADP-ribosylation PURA 538.511084815914 544.852159417815 532.170010214014 0.976723687362547 -0.0339776097181292 0.898066871557712 1 5.08301 4.29175 5.08878 4.02209 GeneID:5813,Genbank:NM_005859.4,HGNC:HGNC:9701,MIM:600473 purine rich element binding protein A GO:0000784,GO:0000900,GO:0003691,GO:0003697,GO:0003705,GO:0003723,GO:0005634,GO:0005662,GO:0005737,GO:0006268,GO:0006270,GO:0006351,GO:0007399,GO:0008134,GO:0008284,GO:0030154,GO:0030425,GO:0032422,GO:0043025,GO:0045892,GO:0046332 nuclear chromosome, telomeric region|translation repressor activity, nucleic acid binding|double-stranded telomeric DNA binding|single-stranded DNA binding|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|RNA binding|nucleus|DNA replication factor A complex|cytoplasm|DNA unwinding involved in DNA replication|DNA replication initiation|transcription, DNA-templated|nervous system development|transcription factor binding|positive regulation of cell proliferation|cell differentiation|dendrite|purine-rich negative regulatory element binding|neuronal cell body|negative regulation of transcription, DNA-templated|SMAD binding PURB 1751.18933910993 1816.22583855301 1686.15283966685 0.928382805637328 -0.107208291777857 0.534134266358379 1 10.2226 9.14024 10.0691 8.04498 GeneID:5814,Genbank:NM_033224.4,HGNC:HGNC:9702,MIM:608887 purine rich element binding protein B GO:0000977,GO:0001227,GO:0003697,GO:0003723,GO:0003729,GO:0005634,GO:0005662,GO:0006351,GO:0008134,GO:0008283,GO:0030154,GO:0045637,GO:0046332 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|single-stranded DNA binding|RNA binding|mRNA binding|nucleus|DNA replication factor A complex|transcription, DNA-templated|transcription factor binding|cell proliferation|cell differentiation|regulation of myeloid cell differentiation|SMAD binding PURG 14.4324697304254 16.7486715608123 12.1162679000385 0.723416651645827 -0.467101288474584 0.543992757083589 1 0.129026 0.194839 0.148316 0.138471 GeneID:29942,Genbank:NM_001015508.2,HGNC:HGNC:17930 purine rich element binding protein G GO:0003677,GO:0003723,GO:0005634 DNA binding|RNA binding|nucleus PUS1 454.670930181456 512.923117053141 396.418743309771 0.772861916591489 -0.371717416886995 0.0342327608124472 0.729903651010146 7.5727 8.33226 6.47193 6.4857 GeneID:80324,Genbank:NM_001002020.2,HGNC:HGNC:15508,MIM:608109 pseudouridylate synthase 1 GO:0003723,GO:0004730,GO:0005634,GO:0005739,GO:0005759,GO:0009982,GO:0031119,GO:0070902,GO:1990481 RNA binding|pseudouridylate synthase activity|nucleus|mitochondrion|mitochondrial matrix|pseudouridine synthase activity|tRNA pseudouridine synthesis|mitochondrial tRNA pseudouridine synthesis|mRNA pseudouridine synthesis PUS10 46.1172567928087 43.2791538505559 48.9553597350615 1.13115334703875 0.177794524390265 0.681098248176521 1 0.196606 0.180808 0.23522 0.145996 GeneID:150962,Genbank:XM_011532574.3,HGNC:HGNC:26505,MIM:612787 pseudouridylate synthase 10 GO:0003723,GO:0009982,GO:0031119 RNA binding|pseudouridine synthase activity|tRNA pseudouridine synthesis PUS3 127.260760562382 138.706773061585 115.814748063178 0.83496101529056 -0.260219255815601 0.343428817432895 1 2.28433 2.17348 1.69384 2.00624 GeneID:83480,Genbank:XM_024448706.1,HGNC:HGNC:25461,MIM:616283 pseudouridylate synthase 3 GO:0003723,GO:0005634,GO:0005737,GO:0005829,GO:0006400,GO:0009982,GO:0031119,GO:1990481 RNA binding|nucleus|cytoplasm|cytosol|tRNA modification|pseudouridine synthase activity|tRNA pseudouridine synthesis|mRNA pseudouridine synthesis PUS7 581.0739038176 664.40894718434 497.738860450859 0.749145330688573 -0.416682472965572 0.0137720685021649 0.481601417315879 5.67133 5.50145 4.63783 3.98822 GeneID:54517,Genbank:NM_001318164.1,HGNC:HGNC:26033,MIM:616261 pseudouridylate synthase 7 (putative) GO:0001522,GO:0003723,GO:0005634,GO:0008033,GO:0009982,GO:0019899 pseudouridine synthesis|RNA binding|nucleus|tRNA processing|pseudouridine synthase activity|enzyme binding PUS7L 88.111458826016 96.2440658806732 79.9788517713588 0.831000343133045 -0.267079022180262 0.533258428892265 1 0.325986 0.22809 0.28885 0.193924 GeneID:83448,Genbank:XM_011538791.3,HGNC:HGNC:25276 pseudouridylate synthase 7 like GO:0001522,GO:0003723,GO:0008033,GO:0009982 pseudouridine synthesis|RNA binding|tRNA processing|pseudouridine synthase activity PUSL1 494.903547394272 493.080129601422 496.726965187122 1.00739603031387 0.010630951119878 0.977068597853046 1 12.7198 12.6702 12.9345 12.0364 GeneID:126789,Genbank:XM_005244720.4,HGNC:HGNC:26914 pseudouridylate synthase-like 1 GO:0003723,GO:0009982,GO:0031119,GO:0043231 RNA binding|pseudouridine synthase activity|tRNA pseudouridine synthesis|intracellular membrane-bounded organelle PVR 4846.72721181484 4834.11315100457 4859.34127262512 1.00521876936524 0.00750951447022678 0.973703918177193 1 28.1327 30.3051 30.8031 29.5316 GeneID:5817,Genbank:NM_006505.4,HGNC:HGNC:9705,MIM:173850 poliovirus receptor hsa04514 Cell adhesion molecules (CAMs) PVRIG 6.18888157542887 6.56303332418548 5.81472982667226 0.885982066439365 -0.174650598049329 0.93933726939209 1 0.105438 0.211727 0.0967953 0.150891 GeneID:79037,Genbank:XM_011516575.2,HGNC:HGNC:32190,MIM:617012 PVR related immunoglobulin domain containing GO:0004872,GO:0005886,GO:0016021,GO:0019902,GO:0050860 receptor activity|plasma membrane|integral component of membrane|phosphatase binding|negative regulation of T cell receptor signaling pathway PWP1 1130.00910424772 1194.34825913533 1065.6699493601 0.892260646096315 -0.164462884851531 0.281595427334595 1 13.9896 13.2727 12.0081 12.2434 GeneID:11137,Genbank:NM_001317963.1,HGNC:HGNC:17015 PWP1 homolog, endonuclein GO:0005634,GO:0005730,GO:0005794,GO:0006351,GO:0033140,GO:0034773,GO:1990889,GO:2000738 nucleus|nucleolus|Golgi apparatus|transcription, DNA-templated|negative regulation of peptidyl-serine phosphorylation of STAT protein|histone H4-K20 trimethylation|H4K20me3 modified histone binding|positive regulation of stem cell differentiation PWP2 11.3539214316714 7.68725495215503 15.0205879111877 1.9539598991675 0.966400859391338 0.271789675764084 1 0.0645437 0.0797109 0.14476 0.135051 GeneID:5822,Genbank:XM_011529667.3,HGNC:HGNC:9711,MIM:601475 PWP2, small subunit processome component GO:0000028,GO:0000462,GO:0003723,GO:0005654,GO:0006364,GO:0030515,GO:0032040,GO:0034388 ribosomal small subunit assembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|rRNA processing|snoRNA binding|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome hsa03008 Ribosome biogenesis in eukaryotes PWWP2A 361.390419716344 329.254236525318 393.52660290737 1.19520589031847 0.257259163273507 0.168317747203577 1 1.38841 1.33541 1.64042 1.56969 GeneID:114825,Genbank:XM_011534424.3,HGNC:HGNC:29406,MIM:617823 PWWP domain containing 2A GO:0003682,GO:0005634,GO:0042393 chromatin binding|nucleus|histone binding PWWP2B 179.290915788312 177.326361266847 181.255470309777 1.02215750108929 0.031617513822768 0.963405382026922 1 2.56166 3.7216 3.398 3.01512 GeneID:170394,Genbank:XM_011539387.2,HGNC:HGNC:25150 PWWP domain containing 2B GO:0005654 nucleoplasm PXDC1 1612.32566426719 1546.36832821561 1678.28300031878 1.0853061134894 0.118102016057783 0.41823379298757 1 26.0077 25.7141 29.5478 27.6687 GeneID:221749,Genbank:NM_183373.3,HGNC:HGNC:21361 PX domain containing 1 GO:0035091 phosphatidylinositol binding PXDN 5010.66110670704 5703.76966970965 4317.55254370444 0.756964743270256 -0.401701988723503 0.00245275546334786 0.180198768353117 30.4928 30.2105 23.9545 22.9844 GeneID:7837,Genbank:XM_011510396.1,HGNC:HGNC:14966,MIM:605158 peroxidasin GO:0004601,GO:0005152,GO:0005201,GO:0005576,GO:0005578,GO:0005615,GO:0005783,GO:0006955,GO:0006979,GO:0020037,GO:0030198,GO:0031012,GO:0042744,GO:0046872,GO:0055114,GO:0070062 peroxidase activity|interleukin-1 receptor antagonist activity|extracellular matrix structural constituent|extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum|immune response|response to oxidative stress|heme binding|extracellular matrix organization|extracellular matrix|hydrogen peroxide catabolic process|metal ion binding|oxidation-reduction process|extracellular exosome PXDNL 2.47576097083079 1.07619535328461 3.87532658837698 3.60095086505369 1.84837791409998 0.420403550203772 1 0.0163607 0 0.00773843 0.0216165 GeneID:137902,Genbank:XM_011517458.2,HGNC:HGNC:26359,MIM:615904 peroxidasin like GO:0004519,GO:0004601,GO:0005615,GO:0005737,GO:0006979,GO:0020037,GO:0042744,GO:0046872,GO:0055114 endonuclease activity|peroxidase activity|extracellular space|cytoplasm|response to oxidative stress|heme binding|hydrogen peroxide catabolic process|metal ion binding|oxidation-reduction process PXK 476.006758631995 543.412388178121 408.601129085868 0.751917214209581 -0.411354264399219 0.0467169469767098 0.79332376136203 2.20943 2.55384 2.21554 1.465 GeneID:54899,Genbank:NM_001349528.1,HGNC:HGNC:23326,MIM:611450 PX domain containing serine/threonine kinase like GO:0003779,GO:0005634,GO:0005737,GO:0005815,GO:0005829,GO:0005886,GO:0006954,GO:0008022,GO:0032780,GO:0035091,GO:0043271,GO:0050804 actin binding|nucleus|cytoplasm|microtubule organizing center|cytosol|plasma membrane|inflammatory response|protein C-terminus binding|negative regulation of ATPase activity|phosphatidylinositol binding|negative regulation of ion transport|modulation of chemical synaptic transmission PXMP2 542.322492069168 565.66751502005 518.977469118287 0.917460266566468 -0.124282415916553 0.596998653523313 1 27.2037 31.1297 23.3818 29.2283 GeneID:5827,Genbank:NM_018663.2,HGNC:HGNC:9716,MIM:617399 peroxisomal membrane protein 2 GO:0005737,GO:0005778,GO:0005779,GO:0016020,GO:0043234 cytoplasm|peroxisomal membrane|integral component of peroxisomal membrane|membrane|protein complex hsa04146 Peroxisome PXMP4 461.61131609581 394.53857718927 528.684055002351 1.3400059856472 0.422239445044421 0.0175082547041762 0.545445222117836 2.94142 2.95599 3.75587 4.36184 GeneID:11264,Genbank:NM_183397.2,HGNC:HGNC:15920,MIM:616397 peroxisomal membrane protein 4 GO:0005777,GO:0005778,GO:0016021 peroxisome|peroxisomal membrane|integral component of membrane hsa04146 Peroxisome PXN 6215.10645080258 6564.92858879807 5865.2843128071 0.893426978446531 -0.162578275120422 0.208501140990843 1 30.0519 31.5602 27.8392 27.9962 GeneID:5829,Genbank:NM_002859.3,HGNC:HGNC:9718,MIM:602505 paxillin hsa04062,hsa04370,hsa04510,hsa04670,hsa04810,hsa05100,hsa05163,hsa05165,hsa05170,hsa05203,hsa05205 Chemokine signaling pathway|VEGF signaling pathway|Focal adhesion|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis|Proteoglycans in cancer PXT1 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0.0187679 0.0350467 GeneID:222659,Genbank:NM_152990.3,HGNC:HGNC:18312 peroxisomal testis enriched protein 1 GO:0005634,GO:0005777,GO:0043065 nucleus|peroxisome|positive regulation of apoptotic process PXYLP1 60.7981241512924 62.468373766047 59.1278745365377 0.946524952898247 -0.079287555204518 0.87240421641157 1 0.651209 0.480305 0.571989 0.49357 GeneID:92370,Genbank:NM_152282.4,HGNC:HGNC:26303 2-phosphoxylose phosphatase 1 GO:0000139,GO:0005794,GO:0006024,GO:0010909,GO:0016021,GO:0016791,GO:0050650 Golgi membrane|Golgi apparatus|glycosaminoglycan biosynthetic process|positive regulation of heparan sulfate proteoglycan biosynthetic process|integral component of membrane|phosphatase activity|chondroitin sulfate proteoglycan biosynthetic process PYCR1 2087.38657160428 2124.94037881997 2049.8327643886 0.964654248570927 -0.0519161506971864 0.700380313586278 1 38.9246 38.9375 36.5439 41.2662 GeneID:5831,Genbank:NM_001282279.1,HGNC:HGNC:9721,MIM:179035 pyrroline-5-carboxylate reductase 1 GO:0004735,GO:0005739,GO:0006561,GO:0034599,GO:0055129 pyrroline-5-carboxylate reductase activity|mitochondrion|proline biosynthetic process|cellular response to oxidative stress|L-proline biosynthetic process hsa00330 Arginine and proline metabolism PYCR2 1445.83174629178 1391.33531141027 1500.32818117329 1.07833688174891 0.108807958890564 0.458433696664463 1 35.8231 33.2146 36.9254 39.1721 GeneID:29920,Genbank:NM_001271681.1,HGNC:HGNC:30262,MIM:616406 pyrroline-5-carboxylate reductase 2 GO:0004735,GO:0005739,GO:0005759,GO:0006561,GO:0008652,GO:0034599,GO:0055129 pyrroline-5-carboxylate reductase activity|mitochondrion|mitochondrial matrix|proline biosynthetic process|cellular amino acid biosynthetic process|cellular response to oxidative stress|L-proline biosynthetic process hsa00330 Arginine and proline metabolism PYCR3 269.09957488126 279.941355372966 258.257794389554 0.922542487677383 -0.116312738890559 0.722805974633499 1 3.56086 4.01684 2.86118 4.2515 GeneID:65263,Genbank:NM_001329866.1,HGNC:HGNC:25846,MIM:616408 pyrroline-5-carboxylate reductase 3 GO:0004735,GO:0005829,GO:0008652,GO:0055129 pyrroline-5-carboxylate reductase activity|cytosol|cellular amino acid biosynthetic process|L-proline biosynthetic process hsa00330 Arginine and proline metabolism PYDC5 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.240948 0 GeneID:107181291,Genbank:NM_001320010.1,HGNC:HGNC:53781 pyrin domain containing 5 GO:0002218,GO:0002230,GO:0003690,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006915,GO:0006954,GO:0006955,GO:0032088,GO:0032461,GO:0032731,GO:0033209,GO:0035458,GO:0035690,GO:0042802,GO:0045087,GO:0050702,GO:0050718,GO:0051092,GO:0070269,GO:0097169,GO:2001056 activation of innate immune response|positive regulation of defense response to virus by host|double-stranded DNA binding|nucleoplasm|cytoplasm|mitochondrion|cytosol|apoptotic process|inflammatory response|immune response|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein oligomerization|positive regulation of interleukin-1 beta production|tumor necrosis factor-mediated signaling pathway|cellular response to interferon-beta|cellular response to drug|identical protein binding|innate immune response|interleukin-1 beta secretion|positive regulation of interleukin-1 beta secretion|positive regulation of NF-kappaB transcription factor activity|pyroptosis|AIM2 inflammasome complex|positive regulation of cysteine-type endopeptidase activity hsa04621 NOD-like receptor signaling pathway PYGB 15775.1678936453 14162.0320543049 17388.3037329857 1.22781135265826 0.29608891454244 0.0230384011789494 0.613948474678957 130.555 134.537 163.387 168.963 GeneID:5834,Genbank:NM_002862.3,HGNC:HGNC:9723,MIM:138550 glycogen phosphorylase B GO:0005576,GO:0005737,GO:0005980,GO:0008184,GO:0016020,GO:0030170,GO:0035578,GO:0043312,GO:0070062,GO:0102250,GO:0102499 extracellular region|cytoplasm|glycogen catabolic process|glycogen phosphorylase activity|membrane|pyridoxal phosphate binding|azurophil granule lumen|neutrophil degranulation|extracellular exosome|linear malto-oligosaccharide phosphorylase activity|SHG alpha-glucan phosphorylase activity hsa00500,hsa04217,hsa04910,hsa04922,hsa04931 Starch and sucrose metabolism|Necroptosis|Insulin signaling pathway|Glucagon signaling pathway|Insulin resistance PYGL 1771.32769235159 1928.43358929188 1614.2217954113 0.837063720718554 -0.256590644076447 0.0714415986155313 0.926484731519311 19.926 19.6697 16.263 17.1672 GeneID:5836,Genbank:NM_001163940.1,HGNC:HGNC:9725,MIM:613741 glycogen phosphorylase L GO:0002060,GO:0005524,GO:0005536,GO:0005576,GO:0005737,GO:0005829,GO:0005977,GO:0005980,GO:0006015,GO:0008144,GO:0008184,GO:0016208,GO:0019842,GO:0030170,GO:0032052,GO:0034774,GO:0042593,GO:0042803,GO:0043312,GO:0070062,GO:0070266,GO:0102250,GO:0102499,GO:1904813 purine nucleobase binding|ATP binding|glucose binding|extracellular region|cytoplasm|cytosol|glycogen metabolic process|glycogen catabolic process|5-phosphoribose 1-diphosphate biosynthetic process|drug binding|glycogen phosphorylase activity|AMP binding|vitamin binding|pyridoxal phosphate binding|bile acid binding|secretory granule lumen|glucose homeostasis|protein homodimerization activity|neutrophil degranulation|extracellular exosome|necroptotic process|linear malto-oligosaccharide phosphorylase activity|SHG alpha-glucan phosphorylase activity|ficolin-1-rich granule lumen hsa00500,hsa04217,hsa04910,hsa04922,hsa04931 Starch and sucrose metabolism|Necroptosis|Insulin signaling pathway|Glucagon signaling pathway|Insulin resistance PYGM 2.21302018995993 1.51824048055703 2.90779989936283 1.91524329419539 0.937527669974993 0.766544435698746 1 0 0.0100218 0.0212798 0.01985 GeneID:5837,Genbank:NM_001164716.1,HGNC:HGNC:9726,MIM:608455 glycogen phosphorylase, muscle associated GO:0000166,GO:0005737,GO:0005829,GO:0005977,GO:0005980,GO:0008184,GO:0030170,GO:0070062,GO:0102250,GO:0102499 nucleotide binding|cytoplasm|cytosol|glycogen metabolic process|glycogen catabolic process|glycogen phosphorylase activity|pyridoxal phosphate binding|extracellular exosome|linear malto-oligosaccharide phosphorylase activity|SHG alpha-glucan phosphorylase activity hsa00500,hsa04217,hsa04910,hsa04922,hsa04931 Starch and sucrose metabolism|Necroptosis|Insulin signaling pathway|Glucagon signaling pathway|Insulin resistance PYGO1 116.476755672196 126.800980590554 106.152530753838 0.837158594984447 -0.256427135763633 0.41252721874016 1 0.726217 0.637735 0.709293 0.428626 GeneID:26108,Genbank:NM_001330326.1,HGNC:HGNC:30256,MIM:606902 pygopus family PHD finger 1 GO:0001822,GO:0002244,GO:0005654,GO:0007289,GO:0009791,GO:0016055,GO:0034504,GO:0045944,GO:0046872,GO:1904837 kidney development|hematopoietic progenitor cell differentiation|nucleoplasm|spermatid nucleus differentiation|post-embryonic development|Wnt signaling pathway|protein localization to nucleus|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|beta-catenin-TCF complex assembly PYGO2 1418.33085510552 1233.0452995806 1603.61641063044 1.30053324981319 0.3791032841155 0.00954496548508284 0.386040826285573 17.5383 17.8257 23.3087 23.1764 GeneID:90780,Genbank:NM_138300.3,HGNC:HGNC:30257,MIM:606903 pygopus family PHD finger 2 GO:0001701,GO:0001822,GO:0002088,GO:0003682,GO:0005654,GO:0007289,GO:0007420,GO:0009791,GO:0030879,GO:0033599,GO:0035034,GO:0035563,GO:0042393,GO:0046872,GO:0048589,GO:0051569,GO:0060021,GO:0060070,GO:1904837 in utero embryonic development|kidney development|lens development in camera-type eye|chromatin binding|nucleoplasm|spermatid nucleus differentiation|brain development|post-embryonic development|mammary gland development|regulation of mammary gland epithelial cell proliferation|histone acetyltransferase regulator activity|positive regulation of chromatin binding|histone binding|metal ion binding|developmental growth|regulation of histone H3-K4 methylation|palate development|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly PYM1 406.51144308876 385.592830440199 427.430055737321 1.10850104564797 0.148610131098708 0.428910511721565 1 11.0906 11.7253 12.5333 12.8804 GeneID:84305,Genbank:NM_032345.2,HGNC:HGNC:30258 PYM homolog 1, exon junction complex associated factor GO:0000184,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0030054,GO:0035145,GO:0043022,GO:0045727,GO:1903259 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|nucleus|nucleoplasm|nucleolus|cytosol|cell junction|exon-exon junction complex|ribosome binding|positive regulation of translation|exon-exon junction complex disassembly hsa03013,hsa03015 RNA transport|mRNA surveillance pathway PYROXD1 51.662901748908 61.642118441295 41.6836850565209 0.676220839104004 -0.564433618424262 0.160232519092376 1 0.404588 0.395184 0.391083 0.284036 GeneID:79912,Genbank:NM_024854.4,HGNC:HGNC:26162,MIM:617220 pyridine nucleotide-disulphide oxidoreductase domain 1 GO:0005634,GO:0016491,GO:0030017,GO:0034599 nucleus|oxidoreductase activity|sarcomere|cellular response to oxidative stress PYROXD2 285.568004409628 255.159436282096 315.97657253716 1.23834954780127 0.30841860025483 0.134980017469889 1 0.464471 0.479481 0.630571 0.543967 GeneID:84795,Genbank:NM_032709.2,HGNC:HGNC:23517,MIM:617889 pyridine nucleotide-disulphide oxidoreductase domain 2 GO:0005622,GO:0016491 intracellular|oxidoreductase activity PYY 2.51108526499374 3.084507235799 1.93766329418849 0.628192170113864 -0.670722133763607 0.833682864814049 1 0 0.0495788 0 0 GeneID:5697,Genbank:NM_004160.5,HGNC:HGNC:9748,MIM:600781 peptide YY hsa04080 Neuroactive ligand-receptor interaction PZP 1.70024060874019 0.490071401957362 2.91040981552302 5.93874648448929 2.5701584476161 0.559276651884379 1 0 0.00479526 0.0291441 0 GeneID:5858,Genbank:XM_017019763.1,HGNC:HGNC:9750,MIM:176420 PZP, alpha-2-macroglobulin like GO:0004866,GO:0004867,GO:0005576,GO:0007565,GO:0070062,GO:0072562 endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|female pregnancy|extracellular exosome|blood microparticle QARS 5791.58332714401 5527.50192048758 6055.66473380043 1.09555181000575 0.131657712781736 0.325096701965109 1 59.2968 60.649 65.7036 67.4199 GeneID:5859,Genbank:NM_001272073.1,HGNC:HGNC:9751,MIM:603727 glutaminyl-tRNA synthetase GO:0004819,GO:0004860,GO:0005524,GO:0005737,GO:0005759,GO:0005829,GO:0006418,GO:0006425,GO:0006469,GO:0007420,GO:0017101,GO:0019901,GO:0032873,GO:0043234,GO:0045892,GO:2001234 glutamine-tRNA ligase activity|protein kinase inhibitor activity|ATP binding|cytoplasm|mitochondrial matrix|cytosol|tRNA aminoacylation for protein translation|glutaminyl-tRNA aminoacylation|negative regulation of protein kinase activity|brain development|aminoacyl-tRNA synthetase multienzyme complex|protein kinase binding|negative regulation of stress-activated MAPK cascade|protein complex|negative regulation of transcription, DNA-templated|negative regulation of apoptotic signaling pathway hsa00970 Aminoacyl-tRNA biosynthesis QDPR 1018.04855554273 961.243052942173 1074.85405814328 1.11819175686458 0.16116761479594 0.292874256651465 1 27.4372 27.9275 30.762 32.3717 GeneID:5860,Genbank:NM_001306140.1,HGNC:HGNC:9752,MIM:612676 quinoid dihydropteridine reductase GO:0001889,GO:0004155,GO:0005737,GO:0005739,GO:0005829,GO:0006520,GO:0006559,GO:0006729,GO:0009055,GO:0010044,GO:0010288,GO:0033762,GO:0035690,GO:0042803,GO:0043005,GO:0051066,GO:0070062,GO:0070402,GO:0070404 liver development|6,7-dihydropteridine reductase activity|cytoplasm|mitochondrion|cytosol|cellular amino acid metabolic process|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process|electron transfer activity|response to aluminum ion|response to lead ion|response to glucagon|cellular response to drug|protein homodimerization activity|neuron projection|dihydrobiopterin metabolic process|extracellular exosome|NADPH binding|NADH binding hsa00790 Folate biosynthesis QKI 4235.84399946743 4293.17916744726 4178.50883148759 0.973290111712749 -0.0390581970290742 0.884088331176424 1 12.5611 11.3107 13.7918 9.71259 GeneID:9444,Genbank:XM_011536260.2,HGNC:HGNC:21100,MIM:609590 QKI, KH domain containing RNA binding GO:0001570,GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0006397,GO:0007286,GO:0008380,GO:0010628,GO:0017124,GO:0042552,GO:0042692,GO:0042759,GO:0051028,GO:0061158 vasculogenesis|RNA binding|mRNA binding|nucleus|cytoplasm|mRNA processing|spermatid development|RNA splicing|positive regulation of gene expression|SH3 domain binding|myelination|muscle cell differentiation|long-chain fatty acid biosynthetic process|mRNA transport|3'-UTR-mediated mRNA destabilization QPCT 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:25797,Genbank:NM_012413.3,HGNC:HGNC:9753,MIM:607065 glutaminyl-peptide cyclotransferase GO:0005576,GO:0006464,GO:0008270,GO:0016603,GO:0017186,GO:0035580,GO:0043312,GO:0070062,GO:1904724,GO:1904813 extracellular region|cellular protein modification process|zinc ion binding|glutaminyl-peptide cyclotransferase activity|peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|specific granule lumen|neutrophil degranulation|extracellular exosome|tertiary granule lumen|ficolin-1-rich granule lumen QPCTL 566.170440935154 543.046778290003 589.294103580305 1.08516269157499 0.117911353022689 0.491092212268679 1 8.20044 8.35646 8.53225 9.01198 GeneID:54814,Genbank:XM_011527048.3,HGNC:HGNC:25952 glutaminyl-peptide cyclotransferase like GO:0000139,GO:0005794,GO:0008270,GO:0016020,GO:0016021,GO:0016603,GO:0017186 Golgi membrane|Golgi apparatus|zinc ion binding|membrane|integral component of membrane|glutaminyl-peptide cyclotransferase activity|peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase QPRT 32.1828950798293 25.6081744156218 38.7576157440368 1.51348608905106 0.597875414941254 0.387357351441658 1 0.318401 0.387678 0.344561 0.670626 GeneID:23475,Genbank:XM_005255223.3,HGNC:HGNC:9755,MIM:606248 quinolinate phosphoribosyltransferase GO:0004514,GO:0005737,GO:0005829,GO:0009435,GO:0019674,GO:0034213,GO:0042803,GO:0051259,GO:0070062 nicotinate-nucleotide diphosphorylase (carboxylating) activity|cytoplasm|cytosol|NAD biosynthetic process|NAD metabolic process|quinolinate catabolic process|protein homodimerization activity|protein oligomerization|extracellular exosome hsa00760 Nicotinate and nicotinamide metabolism QRFP 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0 0 0 0 GeneID:347148,Genbank:NM_198180.2,HGNC:HGNC:29982,MIM:609795 pyroglutamylated RFamide peptide GO:0005184,GO:0005576,GO:0007186,GO:0007218,GO:0007625,GO:0007626,GO:0031854,GO:0045777,GO:0060259 neuropeptide hormone activity|extracellular region|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|grooming behavior|locomotory behavior|orexigenic neuropeptide QRFP receptor binding|positive regulation of blood pressure|regulation of feeding behavior QRICH1 2657.68762306608 2776.3869554902 2538.98829064196 0.914493667974201 -0.128954914212272 0.341732801664598 1 21.9443 22.7085 21.3589 20.0653 GeneID:54870,Genbank:NM_001320584.1,HGNC:HGNC:24713,MIM:617387 glutamine rich 1 GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0007010,GO:0007275,GO:0022604 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|cytoskeleton organization|multicellular organism development|regulation of cell morphogenesis QRICH2 58.4856669840292 55.4250776950121 61.5462562730464 1.11044059535139 0.151132215861651 0.704665408281779 1 0.186735 0.12244 0.188905 0.183086 GeneID:84074,Genbank:XM_005257728.4,HGNC:HGNC:25326 glutamine rich 2 QRSL1 544.722804541448 579.099322625037 510.346286457858 0.881275916788292 -0.182334314718751 0.297621354409179 1 4.65675 4.26306 4.21321 3.72606 GeneID:55278,Genbank:NM_018292.4,HGNC:HGNC:21020,MIM:617209 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 GO:0004040,GO:0005524,GO:0005739,GO:0030956,GO:0031647,GO:0032543,GO:0050567,GO:0070681 amidase activity|ATP binding|mitochondrion|glutamyl-tRNA(Gln) amidotransferase complex|regulation of protein stability|mitochondrial translation|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|glutaminyl-tRNAGln biosynthesis via transamidation hsa00970 Aminoacyl-tRNA biosynthesis QSER1 435.275574195236 466.778953029141 403.772195361331 0.865017997793324 -0.209197944731002 0.486036484932163 1 1.71638 1.64649 1.81702 1.16015 GeneID:79832,Genbank:XM_017018328.1,HGNC:HGNC:26154 glutamine and serine rich 1 QSOX1 5451.74849641939 5159.65076406978 5743.846228769 1.11322383847515 0.154743707854784 0.255058157129478 1 64.3575 69.2186 77.4376 73.9896 GeneID:5768,Genbank:NM_002826.4,HGNC:HGNC:9756,MIM:603120 quiescin sulfhydryl oxidase 1 GO:0002576,GO:0003756,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0016242,GO:0016971,GO:0030173,GO:0031093,GO:0035580,GO:0043231,GO:0043312,GO:0043687,GO:0044267,GO:0045171,GO:0045454,GO:0070062,GO:1904724 platelet degranulation|protein disulfide isomerase activity|extracellular region|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|negative regulation of macroautophagy|flavin-linked sulfhydryl oxidase activity|integral component of Golgi membrane|platelet alpha granule lumen|specific granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|post-translational protein modification|cellular protein metabolic process|intercellular bridge|cell redox homeostasis|extracellular exosome|tertiary granule lumen QSOX2 1394.5615465414 1532.5032671376 1256.61982594519 0.819978562455073 -0.286341902527422 0.0469164848989376 0.79514753665755 13.5492 14.4619 11.8797 11.7252 GeneID:169714,Genbank:NM_181701.3,HGNC:HGNC:30249,MIM:612860 quiescin sulfhydryl oxidase 2 GO:0003756,GO:0005615,GO:0005654,GO:0005794,GO:0005886,GO:0016971,GO:0030173,GO:0031965,GO:0045454 protein disulfide isomerase activity|extracellular space|nucleoplasm|Golgi apparatus|plasma membrane|flavin-linked sulfhydryl oxidase activity|integral component of Golgi membrane|nuclear membrane|cell redox homeostasis QTRT1 496.180590845794 516.026224598301 476.334957093286 0.92308284809379 -0.115467957124501 0.554047290138209 1 18.1497 17.0691 15.3586 18.474 GeneID:81890,Genbank:NM_031209.2,HGNC:HGNC:23797,MIM:609615 queuine tRNA-ribosyltransferase catalytic subunit 1 GO:0005634,GO:0005741,GO:0006400,GO:0008479,GO:0042803,GO:0043234,GO:0046872,GO:0046982,GO:0101030 nucleus|mitochondrial outer membrane|tRNA modification|queuine tRNA-ribosyltransferase activity|protein homodimerization activity|protein complex|metal ion binding|protein heterodimerization activity|tRNA-guanine transglycosylation QTRT2 694.615147131623 808.591732560863 580.638561702382 0.718086196433719 -0.477771064622321 0.0198660782870751 0.575358402571021 7.56069 6.34619 5.66548 4.46525 GeneID:79691,Genbank:NM_024638.3,HGNC:HGNC:25771 queuine tRNA-ribosyltransferase accessory subunit 2 GO:0005737,GO:0005739,GO:0005741,GO:0006400,GO:0008479,GO:0042803,GO:0043234,GO:0046872,GO:0046982,GO:0101030 cytoplasm|mitochondrion|mitochondrial outer membrane|tRNA modification|queuine tRNA-ribosyltransferase activity|protein homodimerization activity|protein complex|metal ion binding|protein heterodimerization activity|tRNA-guanine transglycosylation R3HCC1 1072.86594070131 985.132090124245 1160.59979127838 1.17811591248845 0.236481490055856 0.162409416535845 1 19.6985 21.7242 23.5204 26.5241 GeneID:203069,Genbank:NM_001136108.2,HGNC:HGNC:27329 R3H domain and coiled-coil containing 1 GO:0003676,GO:0035145 nucleic acid binding|exon-exon junction complex R3HCC1L 170.712509333065 175.66302496138 165.761993704749 0.943636224761541 -0.0836972923753699 0.7582564689441 1 1.04553 0.983499 1.17731 0.873194 GeneID:27291,Genbank:NM_001351010.1,HGNC:HGNC:23512 R3H domain and coiled-coil containing 1 like R3HDM1 836.019049283923 871.339472320767 800.698626247078 0.918928444862551 -0.121975568804051 0.528569549396916 1 4.26103 3.92607 4.45819 3.2206 GeneID:23518,Genbank:XM_017003719.1,HGNC:HGNC:9757 R3H domain containing 1 GO:0003723 RNA binding R3HDM2 987.55369771163 986.99530618185 988.112089241411 1.00113149784256 0.00163148349017791 0.998495807927309 1 3.50103 3.78333 3.58434 3.94267 GeneID:22864,Genbank:NM_014925.4,HGNC:HGNC:29167 R3H domain containing 2 GO:0003676,GO:0005634 nucleic acid binding|nucleus R3HDM4 1027.35444130357 1039.93282624835 1014.7760563588 0.975809235698126 -0.0353289569474328 0.794599935727298 1 19.0787 19.9804 19.4865 19.5873 GeneID:91300,Genbank:NM_138774.3,HGNC:HGNC:28270 R3H domain containing 4 GO:0003676,GO:0005634 nucleic acid binding|nucleus RAB10 3311.28607046602 3476.23086309122 3146.34127784083 0.905101358844436 -0.14384873173677 0.2964541596726 1 45.0004 42.9675 42.3378 37.1309 GeneID:10890,Genbank:NM_016131.4,HGNC:HGNC:9759,MIM:612672 RAB10, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005768,GO:0005789,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0005913,GO:0005925,GO:0005929,GO:0006893,GO:0006904,GO:0007409,GO:0009306,GO:0016192,GO:0016197,GO:0017157,GO:0019003,GO:0019882,GO:0030659,GO:0030667,GO:0030670,GO:0030859,GO:0031489,GO:0032593,GO:0032869,GO:0043001,GO:0043312,GO:0045200,GO:0055037,GO:0055038,GO:0070062,GO:0070382,GO:0071782,GO:0071786,GO:0072659,GO:0090150,GO:0097051,GO:0098641,GO:1903361 Golgi membrane|GTPase activity|GTP binding|endosome|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|cell-cell adherens junction|focal adhesion|cilium|Golgi to plasma membrane transport|vesicle docking involved in exocytosis|axonogenesis|protein secretion|vesicle-mediated transport|endosomal transport|regulation of exocytosis|GDP binding|antigen processing and presentation|cytoplasmic vesicle membrane|secretory granule membrane|phagocytic vesicle membrane|polarized epithelial cell differentiation|myosin V binding|insulin-responsive compartment|cellular response to insulin stimulus|Golgi to plasma membrane protein transport|neutrophil degranulation|establishment of neuroblast polarity|recycling endosome|recycling endosome membrane|extracellular exosome|exocytic vesicle|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization|protein localization to plasma membrane|establishment of protein localization to membrane|establishment of protein localization to endoplasmic reticulum membrane|cadherin binding involved in cell-cell adhesion|protein localization to basolateral plasma membrane hsa04144,hsa04152 Endocytosis|AMPK signaling pathway RAB11A 3495.49540316028 3581.63239812992 3409.35840819065 0.951900705938102 -0.0711170029946755 0.612725668429268 1 36.104 36.4515 35.5003 33.8374 GeneID:8766,Genbank:NM_004663.4,HGNC:HGNC:9760,MIM:605570 RAB11A, member RAS oncogene family GO:0001881,GO:0003924,GO:0005525,GO:0005737,GO:0005739,GO:0008021,GO:0019003,GO:0030054,GO:0030670,GO:0031410,GO:0031489,GO:0032402,GO:0033572,GO:0035773,GO:0044070,GO:0045054,GO:0045055,GO:0045056,GO:0045296,GO:0045335,GO:0055037,GO:0055038,GO:0071468,GO:0090150,GO:0098993,GO:1990126,GO:2000008,GO:2001135 receptor recycling|GTPase activity|GTP binding|cytoplasm|mitochondrion|synaptic vesicle|GDP binding|cell junction|phagocytic vesicle membrane|cytoplasmic vesicle|myosin V binding|melanosome transport|transferrin transport|insulin secretion involved in cellular response to glucose stimulus|regulation of anion transport|constitutive secretory pathway|regulated exocytosis|transcytosis|cadherin binding|phagocytic vesicle|recycling endosome|recycling endosome membrane|cellular response to acidic pH|establishment of protein localization to membrane|anchored component of synaptic vesicle membrane|retrograde transport, endosome to plasma membrane|regulation of protein localization to cell surface|regulation of endocytic recycling hsa04144,hsa04961,hsa04962,hsa04972 Endocytosis|Endocrine and other factor-regulated calcium reabsorption|Vasopressin-regulated water reabsorption|Pancreatic secretion RAB11B 2281.59568820467 2250.6682150598 2312.52316134955 1.02748292523787 0.0391144193285403 0.854970267850899 1 63.742 72.0105 66.4394 73.4461 GeneID:9230,Genbank:NM_004218.3,HGNC:HGNC:9761,MIM:604198 RAB11B, member RAS oncogene family GO:0001881,GO:0003924,GO:0005525,GO:0005739,GO:0005829,GO:0008021,GO:0019003,GO:0030054,GO:0030670,GO:0031489,GO:0032402,GO:0033572,GO:0035773,GO:0043687,GO:0044070,GO:0045054,GO:0045055,GO:0045056,GO:0045296,GO:0045335,GO:0055037,GO:0055038,GO:0070062,GO:0071468,GO:0090150,GO:0098993,GO:1990126,GO:2000008,GO:2001135 receptor recycling|GTPase activity|GTP binding|mitochondrion|cytosol|synaptic vesicle|GDP binding|cell junction|phagocytic vesicle membrane|myosin V binding|melanosome transport|transferrin transport|insulin secretion involved in cellular response to glucose stimulus|post-translational protein modification|regulation of anion transport|constitutive secretory pathway|regulated exocytosis|transcytosis|cadherin binding|phagocytic vesicle|recycling endosome|recycling endosome membrane|extracellular exosome|cellular response to acidic pH|establishment of protein localization to membrane|anchored component of synaptic vesicle membrane|retrograde transport, endosome to plasma membrane|regulation of protein localization to cell surface|regulation of endocytic recycling hsa04144,hsa04152,hsa04962 Endocytosis|AMPK signaling pathway|Vasopressin-regulated water reabsorption RAB11FIP1 49.9110225898142 56.2033067450791 43.6187384345492 0.776088471669299 -0.36570697035752 0.384959244833385 1 0.292923 0.232173 0.204672 0.19538 GeneID:80223,Genbank:NM_025151.4,HGNC:HGNC:30265,MIM:608737 RAB11 family interacting protein 1 GO:0005737,GO:0005829,GO:0015031,GO:0017137,GO:0030670,GO:0043231,GO:0045055,GO:0055037,GO:0070164 cytoplasm|cytosol|protein transport|Rab GTPase binding|phagocytic vesicle membrane|intracellular membrane-bounded organelle|regulated exocytosis|recycling endosome|negative regulation of adiponectin secretion hsa04144 Endocytosis RAB11FIP2 186.061726954342 216.049776674877 156.073677233807 0.722396845929976 -0.46913650103193 0.0857239264839492 0.964561165794104 1.48796 1.25832 1.21562 0.810157 GeneID:22841,Genbank:NM_001330167.1,HGNC:HGNC:29152,MIM:608599 RAB11 family interacting protein 2 GO:0003091,GO:0005654,GO:0005768,GO:0005886,GO:0017137,GO:0019901,GO:0030010,GO:0030659,GO:0035773,GO:0042802,GO:0042803,GO:0043231,GO:0045055,GO:0055038,GO:1903078 renal water homeostasis|nucleoplasm|endosome|plasma membrane|Rab GTPase binding|protein kinase binding|establishment of cell polarity|cytoplasmic vesicle membrane|insulin secretion involved in cellular response to glucose stimulus|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|regulated exocytosis|recycling endosome membrane|positive regulation of protein localization to plasma membrane hsa04144 Endocytosis RAB11FIP3 840.413801614761 741.118817572474 939.708785657048 1.26795968929119 0.342508880347881 0.030298025438433 0.688302376485026 3.98676 4.07078 5.64916 5.23099 GeneID:9727,Genbank:XM_017023907.1,HGNC:HGNC:17224,MIM:608738 RAB11 family interacting protein 3 GO:0000910,GO:0005509,GO:0005654,GO:0005768,GO:0005813,GO:0005815,GO:0005829,GO:0016192,GO:0017137,GO:0030306,GO:0030496,GO:0032154,GO:0032456,GO:0042803,GO:0043231,GO:0045171,GO:0051959,GO:0055037,GO:0055038,GO:0070164 cytokinesis|calcium ion binding|nucleoplasm|endosome|centrosome|microtubule organizing center|cytosol|vesicle-mediated transport|Rab GTPase binding|ADP-ribosylation factor binding|midbody|cleavage furrow|endocytic recycling|protein homodimerization activity|intracellular membrane-bounded organelle|intercellular bridge|dynein light intermediate chain binding|recycling endosome|recycling endosome membrane|negative regulation of adiponectin secretion hsa04144 Endocytosis RAB11FIP4 130.863465380557 120.718210013218 141.008720747896 1.16808160701237 0.224141070381678 0.530675201178751 1 0.69878 0.424932 0.572069 0.75557 GeneID:84440,Genbank:NM_032932.5,HGNC:HGNC:30267,MIM:611999 RAB11 family interacting protein 4 GO:0000910,GO:0003407,GO:0005509,GO:0005615,GO:0005768,GO:0005815,GO:0005819,GO:0016032,GO:0017137,GO:0030139,GO:0030306,GO:0030496,GO:0032154,GO:0042803,GO:0048471,GO:0055038,GO:1903452 cytokinesis|neural retina development|calcium ion binding|extracellular space|endosome|microtubule organizing center|spindle|viral process|Rab GTPase binding|endocytic vesicle|ADP-ribosylation factor binding|midbody|cleavage furrow|protein homodimerization activity|perinuclear region of cytoplasm|recycling endosome membrane|positive regulation of G1 to G0 transition hsa04144 Endocytosis RAB11FIP5 1121.31952512274 1041.24915297506 1201.38989727042 1.15379675828576 0.206389115112725 0.178839046095693 1 9.79599 10.9917 12.6444 12.3204 GeneID:26056,Genbank:NM_015470.2,HGNC:HGNC:24845,MIM:605536 RAB11 family interacting protein 5 GO:0000139,GO:0005741,GO:0005769,GO:0005794,GO:0005815,GO:0017137,GO:0030141,GO:0030658,GO:0031901,GO:0035773,GO:0043015,GO:0043231,GO:0045055,GO:0055037,GO:0055038,GO:0070164,GO:0071468,GO:2000008 Golgi membrane|mitochondrial outer membrane|early endosome|Golgi apparatus|microtubule organizing center|Rab GTPase binding|secretory granule|transport vesicle membrane|early endosome membrane|insulin secretion involved in cellular response to glucose stimulus|gamma-tubulin binding|intracellular membrane-bounded organelle|regulated exocytosis|recycling endosome|recycling endosome membrane|negative regulation of adiponectin secretion|cellular response to acidic pH|regulation of protein localization to cell surface hsa04144 Endocytosis RAB12 1439.25749028009 1437.69795549577 1440.81702506442 1.00216948876969 0.00312652043876608 0.974761151687531 1 21.1263 20.8052 22.5969 20.5383 GeneID:201475,Genbank:NM_001025300.2,HGNC:HGNC:31332,MIM:616448 RAB12, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005764,GO:0005765,GO:0005776,GO:0005794,GO:0006914,GO:0008333,GO:0015031,GO:0016239,GO:0019003,GO:0044257,GO:0045335,GO:0055038,GO:0071346 Golgi membrane|GTPase activity|GTP binding|lysosome|lysosomal membrane|autophagosome|Golgi apparatus|autophagy|endosome to lysosome transport|protein transport|positive regulation of macroautophagy|GDP binding|cellular protein catabolic process|phagocytic vesicle|recycling endosome membrane|cellular response to interferon-gamma RAB13 2512.51437822293 2438.67602661692 2586.35272982893 1.06055609748905 0.0848209333897335 0.546528575963811 1 31.3023 32.678 33.0759 34.5718 GeneID:5872,Genbank:NM_002870.3,HGNC:HGNC:9762,MIM:602672 RAB13, member RAS oncogene family GO:0003924,GO:0005525,GO:0005802,GO:0005829,GO:0005886,GO:0005923,GO:0010737,GO:0015031,GO:0016197,GO:0016328,GO:0030027,GO:0030054,GO:0030139,GO:0030659,GO:0030866,GO:0031175,GO:0031410,GO:0032456,GO:0032593,GO:0032869,GO:0034236,GO:0035767,GO:0043005,GO:0043687,GO:0044795,GO:0055037,GO:0055038,GO:0070062,GO:0070830,GO:0072659,GO:0097368,GO:1902463 GTPase activity|GTP binding|trans-Golgi network|cytosol|plasma membrane|bicellular tight junction|protein kinase A signaling|protein transport|endosomal transport|lateral plasma membrane|lamellipodium|cell junction|endocytic vesicle|cytoplasmic vesicle membrane|cortical actin cytoskeleton organization|neuron projection development|cytoplasmic vesicle|endocytic recycling|insulin-responsive compartment|cellular response to insulin stimulus|protein kinase A catalytic subunit binding|endothelial cell chemotaxis|neuron projection|post-translational protein modification|trans-Golgi network to recycling endosome transport|recycling endosome|recycling endosome membrane|extracellular exosome|bicellular tight junction assembly|protein localization to plasma membrane|establishment of Sertoli cell barrier|protein localization to cell leading edge hsa04530 Tight junction RAB14 2615.98619759598 2625.59005951225 2606.38233567971 0.9926844163037 -0.010592950544204 0.944174113219689 1 29.4328 30.4665 31.1444 28.3395 GeneID:51552,Genbank:NM_016322.3,HGNC:HGNC:16524,MIM:612673 RAB14, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005622,GO:0005768,GO:0005802,GO:0005829,GO:0006895,GO:0008543,GO:0009790,GO:0015031,GO:0019003,GO:0030100,GO:0030659,GO:0031489,GO:0031901,GO:0032456,GO:0032880,GO:0042742,GO:0043231,GO:0045335,GO:0055037,GO:0090382 Golgi membrane|GTPase activity|GTP binding|intracellular|endosome|trans-Golgi network|cytosol|Golgi to endosome transport|fibroblast growth factor receptor signaling pathway|embryo development|protein transport|GDP binding|regulation of endocytosis|cytoplasmic vesicle membrane|myosin V binding|early endosome membrane|endocytic recycling|regulation of protein localization|defense response to bacterium|intracellular membrane-bounded organelle|phagocytic vesicle|recycling endosome|phagosome maturation hsa04152 AMPK signaling pathway RAB15 720.455093380591 684.905702172287 756.004484588894 1.10380813328186 0.142489421012037 0.385498545183854 1 5.99221 6.36557 6.75379 6.80326 GeneID:376267,Genbank:NM_001330182.1,HGNC:HGNC:20150 RAB15, member RAS oncogene family GO:0003924,GO:0005525,GO:0005737,GO:0005886,GO:0005929,GO:0006904,GO:0009306,GO:0010008,GO:0048471,GO:0070062,GO:1903307 GTPase activity|GTP binding|cytoplasm|plasma membrane|cilium|vesicle docking involved in exocytosis|protein secretion|endosome membrane|perinuclear region of cytoplasm|extracellular exosome|positive regulation of regulated secretory pathway RAB17 40.509625145256 35.457628729454 45.5616215610581 1.2849596319229 0.361723036664726 0.454639946221738 1 0.181709 0.367931 0.359214 0.317064 GeneID:64284,Genbank:NM_022449.3,HGNC:HGNC:16523,MIM:602206 RAB17, member RAS oncogene family GO:0002415,GO:0003924,GO:0005525,GO:0005622,GO:0005769,GO:0005886,GO:0015031,GO:0016323,GO:0016324,GO:0019003,GO:0030100,GO:0030139,GO:0030425,GO:0032401,GO:0032402,GO:0032456,GO:0042470,GO:0043025,GO:0045056,GO:0046847,GO:0050773,GO:0051489,GO:0051963,GO:0055037,GO:0055038,GO:0060271,GO:0070062 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor|GTPase activity|GTP binding|intracellular|early endosome|plasma membrane|protein transport|basolateral plasma membrane|apical plasma membrane|GDP binding|regulation of endocytosis|endocytic vesicle|dendrite|establishment of melanosome localization|melanosome transport|endocytic recycling|melanosome|neuronal cell body|transcytosis|filopodium assembly|regulation of dendrite development|regulation of filopodium assembly|regulation of synapse assembly|recycling endosome|recycling endosome membrane|cilium assembly|extracellular exosome RAB18 983.274002936981 1016.1564079233 950.39159795066 0.93528081950785 -0.096528493433846 0.6303266133302 1 8.12673 6.97924 8.01846 6.83888 GeneID:22931,Genbank:NM_001256410.1,HGNC:HGNC:14244,MIM:602207 RAB18, member RAS oncogene family GO:0001654,GO:0003924,GO:0005525,GO:0005622,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0007264,GO:0007420,GO:0015031,GO:0019003,GO:0030667,GO:0034389,GO:0043312,GO:0051170,GO:0070062,GO:0071782,GO:0071786 eye development|GTPase activity|GTP binding|intracellular|endoplasmic reticulum membrane|Golgi apparatus|cytosol|plasma membrane|small GTPase mediated signal transduction|brain development|protein transport|GDP binding|secretory granule membrane|lipid particle organization|neutrophil degranulation|nuclear import|extracellular exosome|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization RAB1A 1654.12742524476 1652.1814654154 1656.07338507412 1.00235562481494 0.00339445177908771 0.968859279196117 1 30.8376 29.7606 33.6904 27.7577 GeneID:5861,Genbank:NM_015543.1,HGNC:HGNC:9758,MIM:179508 RAB1A, member RAS oncogene family GO:0000045,GO:0000139,GO:0003924,GO:0005525,GO:0005769,GO:0005789,GO:0005794,GO:0005829,GO:0006888,GO:0006890,GO:0006897,GO:0006914,GO:0007030,GO:0016192,GO:0016477,GO:0019068,GO:0030252,GO:0030658,GO:0032402,GO:0034446,GO:0042470,GO:0042742,GO:0043687,GO:0045296,GO:0047496,GO:0048208,GO:0070062,GO:0072606,GO:0090110,GO:1903020,GO:1904668 autophagosome assembly|Golgi membrane|GTPase activity|GTP binding|early endosome|endoplasmic reticulum membrane|Golgi apparatus|cytosol|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|endocytosis|autophagy|Golgi organization|vesicle-mediated transport|cell migration|virion assembly|growth hormone secretion|transport vesicle membrane|melanosome transport|substrate adhesion-dependent cell spreading|melanosome|defense response to bacterium|post-translational protein modification|cadherin binding|vesicle transport along microtubule|COPII vesicle coating|extracellular exosome|interleukin-8 secretion|cargo loading into COPII-coated vesicle|positive regulation of glycoprotein metabolic process|positive regulation of ubiquitin protein ligase activity hsa05134 Legionellosis RAB1B 5708.74594831618 5621.13600122762 5796.35589540473 1.0311716162247 0.0442844580912566 0.759962064218179 1 111.35 119.443 116.799 124.879 GeneID:81876,Genbank:XM_017018378.1,HGNC:HGNC:18370,MIM:612565 RAB1B, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005739,GO:0005789,GO:0005794,GO:0005829,GO:0006888,GO:0006890,GO:0006914,GO:0015031,GO:0019068,GO:0030133,GO:0033116,GO:0034045,GO:0043687,GO:0048208,GO:0070062,GO:1903020,GO:2000785 Golgi membrane|GTPase activity|GTP binding|mitochondrion|endoplasmic reticulum membrane|Golgi apparatus|cytosol|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|autophagy|protein transport|virion assembly|transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|phagophore assembly site membrane|post-translational protein modification|COPII vesicle coating|extracellular exosome|positive regulation of glycoprotein metabolic process|regulation of autophagosome assembly hsa05134 Legionellosis RAB20 125.53669773686 127.502774401467 123.570621072253 0.96916025280491 -0.0451928566861206 0.875263196547881 1 3.56571 3.5613 3.40059 3.6674 GeneID:55647,Genbank:NM_017817.2,HGNC:HGNC:18260 RAB20, member RAS oncogene family GO:0003924,GO:0005525,GO:0005769,GO:0005794,GO:0005886,GO:0015031,GO:0030100,GO:0030670,GO:0043231,GO:0045335,GO:0071346,GO:0090383,GO:0090385 GTPase activity|GTP binding|early endosome|Golgi apparatus|plasma membrane|protein transport|regulation of endocytosis|phagocytic vesicle membrane|intracellular membrane-bounded organelle|phagocytic vesicle|cellular response to interferon-gamma|phagosome acidification|phagosome-lysosome fusion RAB21 982.600211478309 1025.90101803351 939.299404923106 0.91558482583787 -0.127234541855996 0.455101550013003 1 5.96758 5.59515 6.12278 4.64793 GeneID:23011,Genbank:NM_014999.3,HGNC:HGNC:18263,MIM:612398 RAB21, member RAS oncogene family GO:0003924,GO:0005525,GO:0005768,GO:0005789,GO:0005802,GO:0005829,GO:0005925,GO:0008089,GO:0009898,GO:0012506,GO:0015031,GO:0017157,GO:0019003,GO:0030516,GO:0030659,GO:0031901,GO:0032154,GO:0032580,GO:0048260,GO:0050775,GO:0070062,GO:0098559,GO:1904115,GO:2000643 GTPase activity|GTP binding|endosome|endoplasmic reticulum membrane|trans-Golgi network|cytosol|focal adhesion|anterograde axonal transport|cytoplasmic side of plasma membrane|vesicle membrane|protein transport|regulation of exocytosis|GDP binding|regulation of axon extension|cytoplasmic vesicle membrane|early endosome membrane|cleavage furrow|Golgi cisterna membrane|positive regulation of receptor-mediated endocytosis|positive regulation of dendrite morphogenesis|extracellular exosome|cytoplasmic side of early endosome membrane|axon cytoplasm|positive regulation of early endosome to late endosome transport RAB22A 1216.87899218317 1211.45273192916 1222.30525243719 1.00895826987055 0.012866506361219 0.925323548074757 1 6.63408 6.66282 7.28581 6.16407 GeneID:57403,Genbank:NM_020673.2,HGNC:HGNC:9764,MIM:612966 RAB22A, member RAS oncogene family GO:0001726,GO:0003924,GO:0005525,GO:0005769,GO:0005770,GO:0005886,GO:0006897,GO:0007032,GO:0010008,GO:0015031,GO:0015629,GO:0019003,GO:0030670,GO:0045335,GO:0070062,GO:0097494 ruffle|GTPase activity|GTP binding|early endosome|late endosome|plasma membrane|endocytosis|endosome organization|endosome membrane|protein transport|actin cytoskeleton|GDP binding|phagocytic vesicle membrane|phagocytic vesicle|extracellular exosome|regulation of vesicle size hsa04144 Endocytosis RAB23 424.56259172863 458.966219562292 390.158963894968 0.850082091590654 -0.234325927269887 0.356551756245547 1 4.83787 3.7919 4.03969 3.16978 GeneID:51715,Genbank:NM_001278666.1,HGNC:HGNC:14263,MIM:606144 RAB23, member RAS oncogene family GO:0000045,GO:0003924,GO:0005525,GO:0005737,GO:0005776,GO:0005813,GO:0005829,GO:0005886,GO:0006968,GO:0010008,GO:0015031,GO:0030054,GO:0030670,GO:0042992,GO:0045335,GO:0046039,GO:0060271,GO:0070062,GO:0097094 autophagosome assembly|GTPase activity|GTP binding|cytoplasm|autophagosome|centrosome|cytosol|plasma membrane|cellular defense response|endosome membrane|protein transport|cell junction|phagocytic vesicle membrane|negative regulation of transcription factor import into nucleus|phagocytic vesicle|GTP metabolic process|cilium assembly|extracellular exosome|craniofacial suture morphogenesis RAB24 648.515672614097 637.465845732648 659.565499495547 1.03466798089786 0.0491678893106087 0.78203942539632 1 16.2527 16.4238 17.4914 16.9861 GeneID:53917,Genbank:NM_130781.3,HGNC:HGNC:9765,MIM:612415 RAB24, member RAS oncogene family GO:0003924,GO:0005525,GO:0005739,GO:0005776,GO:0005829,GO:0005886,GO:0006914,GO:0015031,GO:0030667,GO:0043312 GTPase activity|GTP binding|mitochondrion|autophagosome|cytosol|plasma membrane|autophagy|protein transport|secretory granule membrane|neutrophil degranulation RAB25 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0380975 0 0 GeneID:57111,Genbank:NM_020387.3,HGNC:HGNC:18238,MIM:612942 RAB25, member RAS oncogene family GO:0003382,GO:0003924,GO:0005525,GO:0008284,GO:0010634,GO:0015031,GO:0031143,GO:0031260,GO:0031268,GO:0031410,GO:0031489,GO:0060627,GO:0070062 epithelial cell morphogenesis|GTPase activity|GTP binding|positive regulation of cell proliferation|positive regulation of epithelial cell migration|protein transport|pseudopodium|pseudopodium membrane|pseudopodium organization|cytoplasmic vesicle|myosin V binding|regulation of vesicle-mediated transport|extracellular exosome RAB26 196.722010957103 172.9441276137 220.499894300507 1.27497763204213 0.350471936946911 0.131240628790754 1 1.89974 1.81683 2.37028 2.30357 GeneID:25837,Genbank:NM_001308053.1,HGNC:HGNC:14259,MIM:605455 RAB26, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005768,GO:0005886,GO:0006904,GO:0008021,GO:0009306,GO:0017157,GO:0019002,GO:0030658,GO:0030667,GO:0031226,GO:0035272,GO:0043001,GO:0045055 Golgi membrane|GTPase activity|GTP binding|endosome|plasma membrane|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|regulation of exocytosis|GMP binding|transport vesicle membrane|secretory granule membrane|intrinsic component of plasma membrane|exocrine system development|Golgi to plasma membrane protein transport|regulated exocytosis RAB27A 427.03197859091 432.887591054929 421.176366126892 0.972946267876386 -0.0395679622435417 0.865975032514142 1 3.04801 2.60502 3.15074 2.49353 GeneID:5873,Genbank:XM_005254576.5,HGNC:HGNC:9766,MIM:603868 RAB27A, member RAS oncogene family RAB27B 46.8679069516982 48.6601306169789 45.0756832864175 0.926337079553365 -0.110390831736334 0.840527295932356 1 0.235692 0.158441 0.21613 0.137956 GeneID:5874,Genbank:XM_017025913.1,HGNC:HGNC:9767,MIM:603869 RAB27B, member RAS oncogene family GO:0002576,GO:0003924,GO:0005525,GO:0005795,GO:0005886,GO:0016324,GO:0019003,GO:0019904,GO:0030140,GO:0030141,GO:0031088,GO:0031489,GO:0032402,GO:0032585,GO:0042470,GO:0042589,GO:0045921,GO:0070062,GO:0071985,GO:0098993 platelet degranulation|GTPase activity|GTP binding|Golgi stack|plasma membrane|apical plasma membrane|GDP binding|protein domain specific binding|trans-Golgi network transport vesicle|secretory granule|platelet dense granule membrane|myosin V binding|melanosome transport|multivesicular body membrane|melanosome|zymogen granule membrane|positive regulation of exocytosis|extracellular exosome|multivesicular body sorting pathway|anchored component of synaptic vesicle membrane hsa04972 Pancreatic secretion RAB28 614.958548361234 648.841315180436 581.075781542032 0.895559157450449 -0.159139360228889 0.362338670002389 1 13.714 11.5354 11.9168 11.2118 GeneID:9364,Genbank:NM_001017979.2,HGNC:HGNC:9768,MIM:612994 RAB28, member RAS oncogene family GO:0003924,GO:0005525,GO:0005737,GO:0005886,GO:0019003,GO:0035253,GO:0036064,GO:1901998 GTPase activity|GTP binding|cytoplasm|plasma membrane|GDP binding|ciliary rootlet|ciliary basal body|toxin transport RAB29 902.496385567298 1012.19965308978 792.79311804482 0.783237887530183 -0.352477540837164 0.0232130793307804 0.616997337836357 11.3772 11.6209 8.50145 9.57873 GeneID:8934,Genbank:XM_005245571.1,HGNC:HGNC:9789,MIM:603949 RAB29, member RAS oncogene family GO:0001921,GO:0003924,GO:0005525,GO:0005737,GO:0005739,GO:0005769,GO:0005773,GO:0005794,GO:0005801,GO:0005802,GO:0005829,GO:0005856,GO:0005886,GO:0007005,GO:0007030,GO:0007416,GO:0009617,GO:0010977,GO:0015031,GO:0017137,GO:0019003,GO:0019894,GO:0020003,GO:0032438,GO:0039694,GO:0042110,GO:0042147,GO:0042470,GO:0048471,GO:0050862,GO:0055037,GO:0070062,GO:0070840,GO:0072657,GO:0090316,GO:0097708,GO:1901214,GO:1903441,GO:1905279,GO:1990967 positive regulation of receptor recycling|GTPase activity|GTP binding|cytoplasm|mitochondrion|early endosome|vacuole|Golgi apparatus|cis-Golgi network|trans-Golgi network|cytosol|cytoskeleton|plasma membrane|mitochondrion organization|Golgi organization|synapse assembly|response to bacterium|negative regulation of neuron projection development|protein transport|Rab GTPase binding|GDP binding|kinesin binding|symbiont-containing vacuole|melanosome organization|viral RNA genome replication|T cell activation|retrograde transport, endosome to Golgi|melanosome|perinuclear region of cytoplasm|positive regulation of T cell receptor signaling pathway|recycling endosome|extracellular exosome|dynein complex binding|protein localization to membrane|positive regulation of intracellular protein transport|intracellular vesicle|regulation of neuron death|protein localization to ciliary membrane|regulation of retrograde transport, endosome to Golgi|multi-organism toxin transport RAB2A 2093.94812006957 2177.17305407299 2010.72318606614 0.923547708945111 -0.114741604518112 0.419289823730714 1 28.6921 29.542 27.6639 26.2404 GeneID:5862,Genbank:NM_002865.2,HGNC:HGNC:9763,MIM:179509 RAB2A, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005634,GO:0005765,GO:0005789,GO:0005794,GO:0005829,GO:0006888,GO:0007030,GO:0015031,GO:0019003,GO:0033116,GO:0042470,GO:0043687,GO:0070062 Golgi membrane|GTPase activity|GTP binding|nucleus|lysosomal membrane|endoplasmic reticulum membrane|Golgi apparatus|cytosol|ER to Golgi vesicle-mediated transport|Golgi organization|protein transport|GDP binding|endoplasmic reticulum-Golgi intermediate compartment membrane|melanosome|post-translational protein modification|extracellular exosome hsa04152 AMPK signaling pathway RAB2B 475.403458054618 495.270737927568 455.536178181668 0.919772042434473 -0.120651748935267 0.489186940532477 1 5.54172 6.41501 5.32995 5.44868 GeneID:84932,Genbank:NM_032846.3,HGNC:HGNC:20246,MIM:607466 RAB2B, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005789,GO:0005886,GO:0015031,GO:0016192,GO:0045921,GO:0070062,GO:0098793 Golgi membrane|GTPase activity|GTP binding|endoplasmic reticulum membrane|plasma membrane|protein transport|vesicle-mediated transport|positive regulation of exocytosis|extracellular exosome|presynapse RAB30 111.143462343175 104.498844474794 117.788080211556 1.12717112618377 0.172706560900515 0.673913925247233 1 0.36303 0.490242 0.591411 0.38254 GeneID:27314,Genbank:NM_001286060.1,HGNC:HGNC:9770,MIM:605693 RAB30, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005795,GO:0005801,GO:0005802,GO:0007030,GO:0031985,GO:0043231 Golgi membrane|GTPase activity|GTP binding|Golgi stack|cis-Golgi network|trans-Golgi network|Golgi organization|Golgi cisterna|intracellular membrane-bounded organelle RAB31 5294.1323726019 5216.52033665532 5371.74440854848 1.02975624781954 0.0423028794675589 0.746619397248732 1 50.6766 51.3616 55.4882 50.2227 GeneID:11031,Genbank:XM_017025528.2,HGNC:HGNC:9771,MIM:605694 RAB31, member RAS oncogene family GO:0003924,GO:0005525,GO:0005769,GO:0005829,GO:0005886,GO:0019003,GO:0030667,GO:0030670,GO:0031623,GO:0031901,GO:0032588,GO:0032869,GO:0043001,GO:0043312,GO:0045055,GO:0045335,GO:0090382 GTPase activity|GTP binding|early endosome|cytosol|plasma membrane|GDP binding|secretory granule membrane|phagocytic vesicle membrane|receptor internalization|early endosome membrane|trans-Golgi network membrane|cellular response to insulin stimulus|Golgi to plasma membrane protein transport|neutrophil degranulation|regulated exocytosis|phagocytic vesicle|phagosome maturation hsa04144 Endocytosis RAB32 2565.63955358832 2566.325930845 2564.95317633163 0.999465089567588 -0.000771919100360835 0.97210911932847 1 87.8654 103.579 91.1178 101.656 GeneID:10981,Genbank:NM_006834.4,HGNC:HGNC:9772,MIM:612906 RAB32, member RAS oncogene family GO:0003924,GO:0005525,GO:0005739,GO:0005741,GO:0005769,GO:0005783,GO:0005802,GO:0005829,GO:0007005,GO:0016020,GO:0016192,GO:0019882,GO:0030670,GO:0030742,GO:0033162,GO:0035646,GO:0035650,GO:0035651,GO:0036461,GO:0042470,GO:0044233,GO:0045335,GO:0072657,GO:0090382,GO:1903232 GTPase activity|GTP binding|mitochondrion|mitochondrial outer membrane|early endosome|endoplasmic reticulum|trans-Golgi network|cytosol|mitochondrion organization|membrane|vesicle-mediated transport|antigen processing and presentation|phagocytic vesicle membrane|GTP-dependent protein binding|melanosome membrane|endosome to melanosome transport|AP-1 adaptor complex binding|AP-3 adaptor complex binding|BLOC-2 complex binding|melanosome|ER-mitochondrion membrane contact site|phagocytic vesicle|protein localization to membrane|phagosome maturation|melanosome assembly RAB33A 3.47741536240289 2.59443583384164 4.36039489096415 1.68067170291416 0.749037940615955 0.714508163100295 1 0.071512 0.0313812 0.0666874 0.18623 GeneID:9363,Genbank:XM_017029963.2,HGNC:HGNC:9773,MIM:300333 RAB33A, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005886,GO:0019882,GO:2000785 Golgi membrane|GTPase activity|GTP binding|plasma membrane|antigen processing and presentation|regulation of autophagosome assembly RAB33B 113.011246797814 115.539147000642 110.483346594987 0.956241667548164 -0.0645528234253687 0.85789369382139 1 1.5938 1.32454 1.27281 1.52178 GeneID:83452,Genbank:XM_011532299.1,HGNC:HGNC:16075,MIM:605950 RAB33B, member RAS oncogene family GO:0000042,GO:0000045,GO:0000139,GO:0003924,GO:0005525,GO:0005794,GO:0005796,GO:0006891,GO:0048705,GO:0070062,GO:1903358,GO:1903434,GO:2000156,GO:2000785 protein targeting to Golgi|autophagosome assembly|Golgi membrane|GTPase activity|GTP binding|Golgi apparatus|Golgi lumen|intra-Golgi vesicle-mediated transport|skeletal system morphogenesis|extracellular exosome|regulation of Golgi organization|negative regulation of constitutive secretory pathway|regulation of retrograde vesicle-mediated transport, Golgi to ER|regulation of autophagosome assembly hsa04140 Autophagy - animal RAB34 2536.60486531861 2527.08200106884 2546.12772956839 1.0075366483919 0.0108323166605754 0.969238128501936 1 26.7552 30.3016 30.4101 31.7887 GeneID:83871,Genbank:NM_001256278.1,HGNC:HGNC:16519,MIM:610917 RAB34, member RAS oncogene family GO:0003924,GO:0005525,GO:0005794,GO:0005795,GO:0017160,GO:0019882,GO:0030670,GO:0030742,GO:0031982,GO:0031985,GO:0032418,GO:0043001,GO:0045335,GO:0048471,GO:0070062,GO:0072659,GO:0090382,GO:0090385 GTPase activity|GTP binding|Golgi apparatus|Golgi stack|Ral GTPase binding|antigen processing and presentation|phagocytic vesicle membrane|GTP-dependent protein binding|vesicle|Golgi cisterna|lysosome localization|Golgi to plasma membrane protein transport|phagocytic vesicle|perinuclear region of cytoplasm|extracellular exosome|protein localization to plasma membrane|phagosome maturation|phagosome-lysosome fusion RAB35 1820.32173555289 1880.97513254288 1759.66833856291 0.935508560490124 -0.0961772397963504 0.493021847060137 1 24.285 24.0999 23.2973 22.6256 GeneID:11021,Genbank:XM_024448801.1,HGNC:HGNC:9774,MIM:604199 RAB35, member RAS oncogene family GO:0000910,GO:0003924,GO:0005525,GO:0005546,GO:0005739,GO:0005829,GO:0005886,GO:0005905,GO:0008104,GO:0010008,GO:0015031,GO:0016197,GO:0019003,GO:0019882,GO:0030665,GO:0031175,GO:0031253,GO:0032456,GO:0036010,GO:0042470,GO:0045171,GO:0045334,GO:0048227,GO:0055038,GO:0070062,GO:0098993,GO:1990090 cytokinesis|GTPase activity|GTP binding|phosphatidylinositol-4,5-bisphosphate binding|mitochondrion|cytosol|plasma membrane|clathrin-coated pit|protein localization|endosome membrane|protein transport|endosomal transport|GDP binding|antigen processing and presentation|clathrin-coated vesicle membrane|neuron projection development|cell projection membrane|endocytic recycling|protein localization to endosome|melanosome|intercellular bridge|clathrin-coated endocytic vesicle|plasma membrane to endosome transport|recycling endosome membrane|extracellular exosome|anchored component of synaptic vesicle membrane|cellular response to nerve growth factor stimulus hsa04144 Endocytosis RAB36 203.491123597915 209.746492034332 197.235755161498 0.940353057867655 -0.0887255729868944 0.714953660000475 1 1.27625 1.07073 1.11661 1.12265 GeneID:9609,Genbank:XM_011530550.2,HGNC:HGNC:9775,MIM:605662 RAB36, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005794,GO:0015031 Golgi membrane|GTPase activity|GTP binding|Golgi apparatus|protein transport RAB37 14.3497483797007 10.2816907859967 18.4178059734047 1.79132074254647 0.841023680289612 0.274434028511245 1 0.127634 0.113275 0.202723 0.177982 GeneID:326624,Genbank:NM_175738.4,HGNC:HGNC:30268,MIM:609956 RAB37, member RAS oncogene family GO:0003924,GO:0005525,GO:0005768,GO:0005793,GO:0005886,GO:0006904,GO:0008021,GO:0009306,GO:0017157,GO:0030667,GO:0035577,GO:0035579,GO:0043312,GO:0072659 GTPase activity|GTP binding|endosome|endoplasmic reticulum-Golgi intermediate compartment|plasma membrane|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|regulation of exocytosis|secretory granule membrane|azurophil granule membrane|specific granule membrane|neutrophil degranulation|protein localization to plasma membrane RAB38 2.02438538477488 2.59443583384164 1.45433493570811 0.560559223218347 -0.835061292722276 0.824506951681651 1 0.0353348 0.0227727 0.0227835 0.0105919 GeneID:23682,Genbank:XM_017017456.2,HGNC:HGNC:9776,MIM:606281 RAB38, member RAS oncogene family RAB39A 9.79060411833601 9.88767193340919 9.69353630326283 0.98036589083317 -0.0286078044625711 1 1 0.242173 0.153722 0.284578 0.191842 GeneID:54734,Genbank:NM_017516.2,HGNC:HGNC:16521 RAB39A, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005764,GO:0005794,GO:0005829,GO:0005886,GO:0006914,GO:0015031,GO:0030670,GO:0045335,GO:0090383,GO:0090385 Golgi membrane|GTPase activity|GTP binding|lysosome|Golgi apparatus|cytosol|plasma membrane|autophagy|protein transport|phagocytic vesicle membrane|phagocytic vesicle|phagosome acidification|phagosome-lysosome fusion RAB39B 120.896227711468 107.045254033951 134.747201388986 1.25878725409207 0.332034475748297 0.307754535345981 1 0.932044 1.31494 1.71954 1.17555 GeneID:116442,Genbank:NM_171998.3,HGNC:HGNC:16499,MIM:311510 RAB39B, member RAS oncogene family GO:0003924,GO:0005525,GO:0005622,GO:0005794,GO:0005886,GO:0006914,GO:0010506,GO:0015031,GO:0016192,GO:0030659,GO:0031489,GO:0031982,GO:0043005,GO:0050808 GTPase activity|GTP binding|intracellular|Golgi apparatus|plasma membrane|autophagy|regulation of autophagy|protein transport|vesicle-mediated transport|cytoplasmic vesicle membrane|myosin V binding|vesicle|neuron projection|synapse organization RAB3A 138.831759039397 128.886744713077 148.776773365718 1.15432175509529 0.207045416166822 0.456340641053524 1 2.30271 3.19083 2.9409 3.26456 GeneID:5864,Genbank:XM_011528164.2,HGNC:HGNC:9777,MIM:179490 RAB3A, member RAS oncogene family GO:0001669,GO:0001671,GO:0003016,GO:0003924,GO:0005525,GO:0005768,GO:0005829,GO:0005886,GO:0007005,GO:0007269,GO:0007274,GO:0007409,GO:0008021,GO:0008022,GO:0009791,GO:0014047,GO:0015031,GO:0016079,GO:0016188,GO:0030324,GO:0030424,GO:0030667,GO:0030742,GO:0031489,GO:0031630,GO:0036465,GO:0043195,GO:0043234,GO:0043312,GO:0043687,GO:0045054,GO:0045921,GO:0048172,GO:0048790,GO:0050975,GO:0051021,GO:0051117,GO:0051602,GO:0060201,GO:0060203,GO:0061202,GO:0061670,GO:0070083,GO:0098993,GO:1903307,GO:1903561 acrosomal vesicle|ATPase activator activity|respiratory system process|GTPase activity|GTP binding|endosome|cytosol|plasma membrane|mitochondrion organization|neurotransmitter secretion|neuromuscular synaptic transmission|axonogenesis|synaptic vesicle|protein C-terminus binding|post-embryonic development|glutamate secretion|protein transport|synaptic vesicle exocytosis|synaptic vesicle maturation|lung development|axon|secretory granule membrane|GTP-dependent protein binding|myosin V binding|regulation of synaptic vesicle fusion to presynaptic active zone membrane|synaptic vesicle recycling|terminal bouton|protein complex|neutrophil degranulation|post-translational protein modification|constitutive secretory pathway|positive regulation of exocytosis|regulation of short-term neuronal synaptic plasticity|maintenance of presynaptic active zone structure|sensory perception of touch|GDP-dissociation inhibitor binding|ATPase binding|response to electrical stimulus|clathrin-sculpted acetylcholine transport vesicle membrane|clathrin-sculpted glutamate transport vesicle membrane|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|evoked neurotransmitter secretion|clathrin-sculpted monoamine transport vesicle membrane|anchored component of synaptic vesicle membrane|positive regulation of regulated secretory pathway|extracellular vesicle hsa04721,hsa04911 Synaptic vesicle cycle|Insulin secretion RAB3B 394.809017850642 463.906168202297 325.711867498986 0.702107214398908 -0.510236742603844 0.00603356315449692 0.309722908597509 1.29171 1.25057 1.06495 0.755895 GeneID:5865,Genbank:NM_002867.3,HGNC:HGNC:9778,MIM:179510 RAB3B, member RAS oncogene family GO:0003924,GO:0005525,GO:0005737,GO:0005829,GO:0005886,GO:0015031,GO:0017157,GO:0018125,GO:0019003,GO:0019882,GO:0030141,GO:0030742,GO:0031489,GO:0031982,GO:0048471,GO:0051586,GO:0070062,GO:0097494,GO:0098993 GTPase activity|GTP binding|cytoplasm|cytosol|plasma membrane|protein transport|regulation of exocytosis|peptidyl-cysteine methylation|GDP binding|antigen processing and presentation|secretory granule|GTP-dependent protein binding|myosin V binding|vesicle|perinuclear region of cytoplasm|positive regulation of dopamine uptake involved in synaptic transmission|extracellular exosome|regulation of vesicle size|anchored component of synaptic vesicle membrane RAB3D 3.74733417277744 3.13253351048394 4.36213483507094 1.39252615190605 0.477704421907052 0.831026716970695 1 0.0434491 0.0195096 0.0509567 0.0381814 GeneID:9545,Genbank:NM_004283.3,HGNC:HGNC:9779,MIM:604350 RAB3D, member RAS oncogene family GO:0003924,GO:0005525,GO:0005739,GO:0005881,GO:0005886,GO:0015031,GO:0018125,GO:0030133,GO:0030742,GO:0031489,GO:0035577,GO:0042588,GO:0043312,GO:0045453,GO:0070062,GO:0099503,GO:1903307 GTPase activity|GTP binding|mitochondrion|cytoplasmic microtubule|plasma membrane|protein transport|peptidyl-cysteine methylation|transport vesicle|GTP-dependent protein binding|myosin V binding|azurophil granule membrane|zymogen granule|neutrophil degranulation|bone resorption|extracellular exosome|secretory vesicle|positive regulation of regulated secretory pathway hsa04972 Pancreatic secretion RAB3GAP1 941.143961558374 908.103619121822 974.184303994926 1.07276778055021 0.101337813180469 0.494660746489363 1 6.28681 5.8337 7.45807 5.73632 GeneID:22930,Genbank:NM_001172435.1,HGNC:HGNC:17063,MIM:602536 RAB3 GTPase activating protein catalytic subunit 1 GO:0005085,GO:0005096,GO:0005789,GO:0005794,GO:0005811,GO:0005829,GO:0007420,GO:0010628,GO:0017137,GO:0021854,GO:0034389,GO:0043010,GO:0043087,GO:0043234,GO:0043547,GO:0048172,GO:0060079,GO:0060325,GO:0061646,GO:0070062,GO:0071782,GO:0097051,GO:0098794,GO:1903061,GO:1903233,GO:1903373,GO:2000786 guanyl-nucleotide exchange factor activity|GTPase activator activity|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|cytosol|brain development|positive regulation of gene expression|Rab GTPase binding|hypothalamus development|lipid particle organization|camera-type eye development|regulation of GTPase activity|protein complex|positive regulation of GTPase activity|regulation of short-term neuronal synaptic plasticity|excitatory postsynaptic potential|face morphogenesis|positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization|extracellular exosome|endoplasmic reticulum tubular network|establishment of protein localization to endoplasmic reticulum membrane|postsynapse|positive regulation of protein lipidation|regulation of calcium ion-dependent exocytosis of neurotransmitter|positive regulation of endoplasmic reticulum tubular network organization|positive regulation of autophagosome assembly RAB3GAP2 365.606990609584 369.640988238815 361.572992980354 0.978173429042864 -0.0318378188323235 0.90060970319316 1 1.93687 1.74153 2.07739 1.46077 GeneID:25782,Genbank:NM_012414.3,HGNC:HGNC:17168,MIM:609275 RAB3 GTPase activating non-catalytic protein subunit 2 GO:0005096,GO:0005789,GO:0005829,GO:0005886,GO:0006886,GO:0008047,GO:0017137,GO:0030234,GO:0043087,GO:0043234,GO:0046982,GO:0097051,GO:1903061,GO:1903373,GO:2000786 GTPase activator activity|endoplasmic reticulum membrane|cytosol|plasma membrane|intracellular protein transport|enzyme activator activity|Rab GTPase binding|enzyme regulator activity|regulation of GTPase activity|protein complex|protein heterodimerization activity|establishment of protein localization to endoplasmic reticulum membrane|positive regulation of protein lipidation|positive regulation of endoplasmic reticulum tubular network organization|positive regulation of autophagosome assembly RAB3IL1 60.2009393917337 62.2380510477302 58.1638277357372 0.934538064039496 -0.0976746682816659 0.795399884251314 1 0.420788 0.583953 0.500703 0.316031 GeneID:5866,Genbank:NM_001271686.1,HGNC:HGNC:9780 RAB3A interacting protein like 1 GO:0005829,GO:0015031,GO:0017112 cytosol|protein transport|Rab guanyl-nucleotide exchange factor activity RAB3IP 311.628042813521 328.572060024621 294.684025602422 0.896862702143148 -0.157040950431866 0.440483227613577 1 0.808568 0.72661 0.764631 0.598657 GeneID:117177,Genbank:XM_006719226.3,HGNC:HGNC:16508,MIM:608686 RAB3A interacting protein GO:0005634,GO:0005813,GO:0005829,GO:0005856,GO:0006612,GO:0006893,GO:0017112,GO:0030027,GO:0033365,GO:0036064,GO:0042802,GO:0060271,GO:0097711 nucleus|centrosome|cytosol|cytoskeleton|protein targeting to membrane|Golgi to plasma membrane transport|Rab guanyl-nucleotide exchange factor activity|lamellipodium|protein localization to organelle|ciliary basal body|identical protein binding|cilium assembly|ciliary basal body-plasma membrane docking RAB40A 3.82350671212165 4.25675513845349 3.39025828578981 0.796441931828268 -0.32835891545605 0.960059383839991 1 0.212 0.0310332 0.0326958 0.0609601 GeneID:142684,Genbank:NM_080879.2,HGNC:HGNC:18283 RAB40A, member RAS oncogene family GO:0003924,GO:0005525,GO:0005768,GO:0005886,GO:0008021,GO:0016567,GO:0030667,GO:0035556,GO:0072659 GTPase activity|GTP binding|endosome|plasma membrane|synaptic vesicle|protein ubiquitination|secretory granule membrane|intracellular signal transduction|protein localization to plasma membrane RAB40AL 1.48541773607917 1.51824048055703 1.45259499160132 0.956762127083039 -0.0637678125324669 1 1 0 0.0449132 0 0.130677 GeneID:282808,Genbank:NM_001031834.1,HGNC:HGNC:25410,MIM:300405 RAB40A like GO:0003924,GO:0005525,GO:0005737,GO:0005739,GO:0005768,GO:0005886,GO:0008021,GO:0016567,GO:0030667,GO:0035556,GO:0072659 GTPase activity|GTP binding|cytoplasm|mitochondrion|endosome|plasma membrane|synaptic vesicle|protein ubiquitination|secretory granule membrane|intracellular signal transduction|protein localization to plasma membrane RAB40B 168.033117519053 148.056347318352 188.009887719754 1.26985361401287 0.344662195808464 0.207557277604872 1 1.41306 1.22327 1.44533 1.94412 GeneID:10966,Genbank:NM_006822.2,HGNC:HGNC:18284 RAB40B, member RAS oncogene family GO:0003924,GO:0005525,GO:0005635,GO:0005768,GO:0005886,GO:0008021,GO:0016567,GO:0030667,GO:0035556,GO:0048471,GO:0072659,GO:1990967 GTPase activity|GTP binding|nuclear envelope|endosome|plasma membrane|synaptic vesicle|protein ubiquitination|secretory granule membrane|intracellular signal transduction|perinuclear region of cytoplasm|protein localization to plasma membrane|multi-organism toxin transport RAB40C 337.927593606549 328.36135461652 347.493832596579 1.05826653383862 0.0817030287939647 0.694748978051754 1 5.50603 5.84138 6.55622 5.66982 GeneID:57799,Genbank:NM_001172663.1,HGNC:HGNC:18285 RAB40C, member RAS oncogene family GO:0003924,GO:0005525,GO:0005768,GO:0005886,GO:0008021,GO:0016567,GO:0019003,GO:0030667,GO:0035556,GO:0048471,GO:0072659 GTPase activity|GTP binding|endosome|plasma membrane|synaptic vesicle|protein ubiquitination|GDP binding|secretory granule membrane|intracellular signal transduction|perinuclear region of cytoplasm|protein localization to plasma membrane RAB41 2.81045529810766 4.65077399104097 0.97013660517434 0.208596807121388 -2.26121101941412 0.294647287208125 1 0.0469652 0.0431432 0 0 GeneID:347517,Genbank:XM_011530948.3,HGNC:HGNC:18293 RAB41, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005794,GO:0005829,GO:0006890,GO:0006891,GO:0042147 Golgi membrane|GTPase activity|GTP binding|Golgi apparatus|cytosol|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|retrograde transport, endosome to Golgi RAB42 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0 0 0.0183443 GeneID:115273,Genbank:NM_152304.2,HGNC:HGNC:28702 RAB42, member RAS oncogene family GO:0003924,GO:0005525,GO:0016020 GTPase activity|GTP binding|membrane RAB43 42.921082512386 43.6829813582513 42.1591836665207 0.965116902639185 -0.0512243912185647 0.907699120221137 1 1.42931 1.66698 1.70993 1.82958 GeneID:339122,Genbank:NM_001204883.1,HGNC:HGNC:19983 RAB43, member RAS oncogene family GO:0003924,GO:0005525,GO:0005768,GO:0005794,GO:0007030,GO:0019068,GO:0030670,GO:0032588,GO:0035526,GO:0045335,GO:0070062,GO:0071346,GO:0090382,GO:1901998 GTPase activity|GTP binding|endosome|Golgi apparatus|Golgi organization|virion assembly|phagocytic vesicle membrane|trans-Golgi network membrane|retrograde transport, plasma membrane to Golgi|phagocytic vesicle|extracellular exosome|cellular response to interferon-gamma|phagosome maturation|toxin transport RAB44 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00606316 0 0 0 GeneID:401258,Genbank:XM_024446437.1,HGNC:HGNC:21068 RAB44, member RAS oncogene family GO:0003924,GO:0005525,GO:0005886,GO:0035577,GO:0035579,GO:0043312 GTPase activity|GTP binding|plasma membrane|azurophil granule membrane|specific granule membrane|neutrophil degranulation RAB4A 1281.99552267041 1217.79626819099 1346.19477714983 1.10543513091035 0.14461436747905 0.37041615272811 1 20.5901 23.5506 22.4899 25.3801 GeneID:5867,Genbank:NM_004578.3,HGNC:HGNC:9781,MIM:179511 RAB4A, member RAS oncogene family GO:0001671,GO:0003924,GO:0005525,GO:0005768,GO:0005829,GO:0005886,GO:0006661,GO:0008565,GO:0019003,GO:0019882,GO:0019905,GO:0030100,GO:0030659,GO:0031901,GO:0031982,GO:0032482,GO:0032593,GO:0035255,GO:0043231,GO:0048471,GO:0051117,GO:0055038,GO:0070062,GO:0098837 ATPase activator activity|GTPase activity|GTP binding|endosome|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|protein transporter activity|GDP binding|antigen processing and presentation|syntaxin binding|regulation of endocytosis|cytoplasmic vesicle membrane|early endosome membrane|vesicle|Rab protein signal transduction|insulin-responsive compartment|ionotropic glutamate receptor binding|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|ATPase binding|recycling endosome membrane|extracellular exosome|postsynaptic recycling endosome hsa04144 Endocytosis RAB4B 450.221384339928 444.910070386401 455.532698293455 1.02387589900545 0.0340408611002023 0.882481854237677 1 14.7064 16.6668 15.988 17.1237 GeneID:53916,Genbank:NM_016154.4,HGNC:HGNC:9782,MIM:612945 RAB4B, member RAS oncogene family GO:0003924,GO:0005525,GO:0005768,GO:0005886,GO:0015031,GO:0030100,GO:0032593 GTPase activity|GTP binding|endosome|plasma membrane|protein transport|regulation of endocytosis|insulin-responsive compartment RAB5A 1508.01601261818 1498.5794281955 1517.45259704087 1.01259403972207 0.0180558974694633 0.87169678118098 1 25.1149 21.6558 25.6132 22.0617 GeneID:5868,Genbank:NM_004162.4,HGNC:HGNC:9783,MIM:179512 RAB5A, member RAS oncogene family GO:0001726,GO:0003924,GO:0005525,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006661,GO:0006897,GO:0006909,GO:0007596,GO:0008021,GO:0010008,GO:0015031,GO:0015629,GO:0019003,GO:0030100,GO:0030139,GO:0030424,GO:0030425,GO:0030665,GO:0030670,GO:0031901,GO:0036465,GO:0036477,GO:0039694,GO:0042470,GO:0043025,GO:0043195,GO:0043679,GO:0043687,GO:0045022,GO:0045056,GO:0045121,GO:0045921,GO:0051036,GO:0051489,GO:0061024,GO:0070062,GO:0098559,GO:2000286,GO:2000300,GO:2000785 ruffle|GTPase activity|GTP binding|cytoplasm|endosome|early endosome|cytosol|plasma membrane|phosphatidylinositol biosynthetic process|endocytosis|phagocytosis|blood coagulation|synaptic vesicle|endosome membrane|protein transport|actin cytoskeleton|GDP binding|regulation of endocytosis|endocytic vesicle|axon|dendrite|clathrin-coated vesicle membrane|phagocytic vesicle membrane|early endosome membrane|synaptic vesicle recycling|somatodendritic compartment|viral RNA genome replication|melanosome|neuronal cell body|terminal bouton|axon terminus|post-translational protein modification|early endosome to late endosome transport|transcytosis|membrane raft|positive regulation of exocytosis|regulation of endosome size|regulation of filopodium assembly|membrane organization|extracellular exosome|cytoplasmic side of early endosome membrane|receptor internalization involved in canonical Wnt signaling pathway|regulation of synaptic vesicle exocytosis|regulation of autophagosome assembly hsa04014,hsa04144,hsa04145,hsa04962,hsa05014,hsa05146,hsa05152 Ras signaling pathway|Endocytosis|Phagosome|Vasopressin-regulated water reabsorption|Amyotrophic lateral sclerosis (ALS)|Amoebiasis|Tuberculosis RAB5B 835.48753259681 845.63626235663 825.33880283699 0.975997411152787 -0.0350507738635333 0.824942405587195 1 15.5473 17.0505 16.0562 15.6117 GeneID:5869,Genbank:NM_001252036.1,HGNC:HGNC:9784,MIM:179514 RAB5B, member RAS oncogene family GO:0003924,GO:0005525,GO:0005622,GO:0005768,GO:0005769,GO:0005886,GO:0007032,GO:0015031,GO:0016020,GO:0019003,GO:0019882,GO:0030100,GO:0030139,GO:0030667,GO:0030742,GO:0031901,GO:0042470,GO:0043231,GO:0043312,GO:0048227,GO:0070062,GO:0098993 GTPase activity|GTP binding|intracellular|endosome|early endosome|plasma membrane|endosome organization|protein transport|membrane|GDP binding|antigen processing and presentation|regulation of endocytosis|endocytic vesicle|secretory granule membrane|GTP-dependent protein binding|early endosome membrane|melanosome|intracellular membrane-bounded organelle|neutrophil degranulation|plasma membrane to endosome transport|extracellular exosome|anchored component of synaptic vesicle membrane hsa04014,hsa04144,hsa04145,hsa04962,hsa05146,hsa05152 Ras signaling pathway|Endocytosis|Phagosome|Vasopressin-regulated water reabsorption|Amoebiasis|Tuberculosis RAB5C 6358.819941231 6047.94082170521 6669.69906075679 1.10280494756499 0.141177644904944 0.293884408229934 1 98.0583 100.795 106.809 111.558 GeneID:5878,Genbank:NM_004583.3,HGNC:HGNC:9785,MIM:604037 RAB5C, member RAS oncogene family GO:0003924,GO:0005525,GO:0005765,GO:0005768,GO:0005769,GO:0005811,GO:0005886,GO:0015031,GO:0019003,GO:0030100,GO:0030139,GO:0031901,GO:0035577,GO:0042470,GO:0043312,GO:0048227,GO:0070062,GO:0098993 GTPase activity|GTP binding|lysosomal membrane|endosome|early endosome|lipid droplet|plasma membrane|protein transport|GDP binding|regulation of endocytosis|endocytic vesicle|early endosome membrane|azurophil granule membrane|melanosome|neutrophil degranulation|plasma membrane to endosome transport|extracellular exosome|anchored component of synaptic vesicle membrane hsa04014,hsa04144,hsa04145,hsa04962,hsa05146,hsa05152 Ras signaling pathway|Endocytosis|Phagosome|Vasopressin-regulated water reabsorption|Amoebiasis|Tuberculosis RAB5IF 656.618642997855 620.775009101628 692.462276894081 1.11548027343465 0.157665000655431 0.451603358842162 1 111.14 114.178 116.572 128.396 GeneID:55969,Genbank:NM_001199534.1,HGNC:HGNC:15870 RAB5 interacting factor GO:0005739 mitochondrion RAB6A 1954.51604908562 2060.614529648 1848.41756852324 0.897022486218706 -0.15678394435865 0.274018539274881 1 25.1399 24.0093 22.9678 21.4809 GeneID:5870,Genbank:NM_001243718.1,HGNC:HGNC:9786,MIM:179513 RAB6A, member RAS oncogene family GO:0000278,GO:0003924,GO:0005525,GO:0005622,GO:0005634,GO:0005794,GO:0005813,GO:0005829,GO:0006890,GO:0006891,GO:0007264,GO:0010824,GO:0042147,GO:0042493 mitotic cell cycle|GTPase activity|GTP binding|intracellular|nucleus|Golgi apparatus|centrosome|cytosol|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|small GTPase mediated signal transduction|regulation of centrosome duplication|retrograde transport, endosome to Golgi|response to drug RAB6B 177.205314357347 175.586589722226 178.824038992467 1.01843790733314 0.0263580239824441 0.934593357630059 1 1.17024 1.25835 1.24434 1.20436 GeneID:51560,Genbank:NM_016577.3,HGNC:HGNC:14902,MIM:615852 RAB6B, member RAS oncogene family GO:0000139,GO:0003924,GO:0005525,GO:0005793,GO:0005794,GO:0005829,GO:0006890,GO:0006891,GO:0015031,GO:0031410,GO:0031489,GO:0042147 Golgi membrane|GTPase activity|GTP binding|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|protein transport|cytoplasmic vesicle|myosin V binding|retrograde transport, endosome to Golgi RAB6C 7.17922481018049 6.12098819691306 8.23746142344792 1.34577312656839 0.428435217702767 0.753632920588086 1 0.0833685 0.110979 0.111524 0.148666 GeneID:84084,Genbank:NM_032144.2,HGNC:HGNC:16525,MIM:612909 RAB6C, member RAS oncogene family GO:0000278,GO:0003924,GO:0005525,GO:0005622,GO:0005634,GO:0005794,GO:0005813,GO:0005829,GO:0006890,GO:0006891,GO:0007264,GO:0010824,GO:0042147,GO:0042493 mitotic cell cycle|GTPase activity|GTP binding|intracellular|nucleus|Golgi apparatus|centrosome|cytosol|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|small GTPase mediated signal transduction|regulation of centrosome duplication|retrograde transport, endosome to Golgi|response to drug RAB6D 13.2632571352989 15.8645813062674 10.6619329643304 0.672058893865563 -0.573340430090451 0.484058736659616 1 0.198754 0.23196 0.150096 0.139963 GeneID:150786,Genbank:NM_001077637.1,HGNC:HGNC:30272 RAB6D, member RAS oncogene family GO:0000278,GO:0003924,GO:0005525,GO:0005622,GO:0005634,GO:0005794,GO:0005813,GO:0005829,GO:0006890,GO:0006891,GO:0007264,GO:0010824,GO:0042147,GO:0042493 mitotic cell cycle|GTPase activity|GTP binding|intracellular|nucleus|Golgi apparatus|centrosome|cytosol|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport|small GTPase mediated signal transduction|regulation of centrosome duplication|retrograde transport, endosome to Golgi|response to drug RAB7A 7088.58888404597 6874.36316183186 7302.81460626008 1.06232598341721 0.0872265368531397 0.505219029049756 1 93.2081 92.6533 101.647 98.9649 GeneID:7879,Genbank:NM_004637.5,HGNC:HGNC:9788,MIM:602298 RAB7A, member RAS oncogene family hsa04137,hsa04140,hsa04144,hsa04145,hsa05132,hsa05146,hsa05152 Mitophagy - animal|Autophagy - animal|Endocytosis|Phagosome|Salmonella infection|Amoebiasis|Tuberculosis RAB7B 6.87778821340818 4.06465003971372 9.69092638710264 2.38419698926532 1.25350344037027 0.291582733076224 1 0.0341482 0.0414306 0.0535896 0.110145 GeneID:338382,Genbank:NM_001304839.1,HGNC:HGNC:30513 RAB7B, member RAS oncogene family GO:0003924,GO:0005525,GO:0005764,GO:0005770,GO:0005794,GO:0005802,GO:0015031,GO:0030670,GO:0031902,GO:0032755,GO:0034144,GO:0034164,GO:0034499,GO:0045335,GO:0045654,GO:0051092,GO:0071346 GTPase activity|GTP binding|lysosome|late endosome|Golgi apparatus|trans-Golgi network|protein transport|phagocytic vesicle membrane|late endosome membrane|positive regulation of interleukin-6 production|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of toll-like receptor 9 signaling pathway|late endosome to Golgi transport|phagocytic vesicle|positive regulation of megakaryocyte differentiation|positive regulation of NF-kappaB transcription factor activity|cellular response to interferon-gamma hsa04137,hsa04140,hsa04145,hsa05132,hsa05146 Mitophagy - animal|Autophagy - animal|Phagosome|Salmonella infection|Amoebiasis RAB8A 3131.98978832928 3243.70298919513 3020.27658746342 0.931119956890026 -0.102961051633821 0.450717249016874 1 37.6927 37.3944 37.8807 33.7677 GeneID:4218,Genbank:NM_005370.4,HGNC:HGNC:7007,MIM:165040 RAB8A, member RAS oncogene family GO:0003924,GO:0005525,GO:0005768,GO:0005794,GO:0005814,GO:0005886,GO:0005929,GO:0006904,GO:0006914,GO:0007409,GO:0008021,GO:0009306,GO:0010506,GO:0017137,GO:0017157,GO:0019003,GO:0030667,GO:0030670,GO:0032456,GO:0032869,GO:0045335,GO:0055038,GO:0060271,GO:0070382,GO:0072659 GTPase activity|GTP binding|endosome|Golgi apparatus|centriole|plasma membrane|cilium|vesicle docking involved in exocytosis|autophagy|axonogenesis|synaptic vesicle|protein secretion|regulation of autophagy|Rab GTPase binding|regulation of exocytosis|GDP binding|secretory granule membrane|phagocytic vesicle membrane|endocytic recycling|cellular response to insulin stimulus|phagocytic vesicle|recycling endosome membrane|cilium assembly|exocytic vesicle|protein localization to plasma membrane hsa04144,hsa04152,hsa04530,hsa04972 Endocytosis|AMPK signaling pathway|Tight junction|Pancreatic secretion RAB8B 369.045250523876 391.520696537517 346.569804510235 0.885188976151672 -0.17594261047951 0.558316545341813 1 1.9287 1.68354 1.98152 1.25397 GeneID:51762,Genbank:NM_016530.2,HGNC:HGNC:30273,MIM:613532 RAB8B, member RAS oncogene family GO:0003924,GO:0005102,GO:0005525,GO:0005654,GO:0005739,GO:0005768,GO:0005778,GO:0005886,GO:0006904,GO:0008021,GO:0009306,GO:0016604,GO:0017157,GO:0019003,GO:0019882,GO:0030667,GO:0030670,GO:0030911,GO:0031346,GO:0034332,GO:0043231,GO:0045046,GO:0045335,GO:0048471,GO:0051286,GO:0051461,GO:0055038,GO:0070062,GO:0072659 GTPase activity|receptor binding|GTP binding|nucleoplasm|mitochondrion|endosome|peroxisomal membrane|plasma membrane|vesicle docking involved in exocytosis|synaptic vesicle|protein secretion|nuclear body|regulation of exocytosis|GDP binding|antigen processing and presentation|secretory granule membrane|phagocytic vesicle membrane|TPR domain binding|positive regulation of cell projection organization|adherens junction organization|intracellular membrane-bounded organelle|protein import into peroxisome membrane|phagocytic vesicle|perinuclear region of cytoplasm|cell tip|positive regulation of corticotropin secretion|recycling endosome membrane|extracellular exosome|protein localization to plasma membrane hsa04530 Tight junction RAB9A 300.182176772611 284.860669701901 315.503683843321 1.10757193744397 0.14740040570868 0.462274579190621 1 9.01868 9.09798 10.1298 9.16492 GeneID:9367,Genbank:NM_004251.4,HGNC:HGNC:9792,MIM:300284 RAB9A, member RAS oncogene family GO:0003924,GO:0005525,GO:0005764,GO:0005770,GO:0005789,GO:0005829,GO:0005886,GO:0015031,GO:0019003,GO:0030133,GO:0030670,GO:0032588,GO:0032880,GO:0042147,GO:0042470,GO:0042802,GO:0045335,GO:0045921,GO:0052405,GO:0070062 GTPase activity|GTP binding|lysosome|late endosome|endoplasmic reticulum membrane|cytosol|plasma membrane|protein transport|GDP binding|transport vesicle|phagocytic vesicle membrane|trans-Golgi network membrane|regulation of protein localization|retrograde transport, endosome to Golgi|melanosome|identical protein binding|phagocytic vesicle|positive regulation of exocytosis|negative regulation by host of symbiont molecular function|extracellular exosome hsa05162 Measles RAB9B 68.0438515162871 66.7829638342934 69.3047391982809 1.03776075842104 0.0534738883763294 0.896112683301837 1 0.770572 0.781849 0.840254 0.759575 GeneID:51209,Genbank:NM_016370.3,HGNC:HGNC:14090,MIM:300285 RAB9B, member RAS oncogene family GO:0003924,GO:0005525,GO:0005829,GO:0005886,GO:0015031,GO:0019003,GO:0030667,GO:0030670,GO:0042147,GO:0042802,GO:0043312,GO:0045335 GTPase activity|GTP binding|cytosol|plasma membrane|protein transport|GDP binding|secretory granule membrane|phagocytic vesicle membrane|retrograde transport, endosome to Golgi|identical protein binding|neutrophil degranulation|phagocytic vesicle hsa05162 Measles RABAC1 1402.85987962254 1254.55162333779 1551.16813590729 1.23643228947433 0.306183235834348 0.110025939273091 1 99.6341 107.497 125.341 144.042 GeneID:10567,Genbank:NM_006423.2,HGNC:HGNC:9794,MIM:604925 Rab acceptor 1 GO:0005794,GO:0005886,GO:0008021,GO:0008022,GO:0016020,GO:0016021,GO:0030054,GO:0042802,GO:0070064 Golgi apparatus|plasma membrane|synaptic vesicle|protein C-terminus binding|membrane|integral component of membrane|cell junction|identical protein binding|proline-rich region binding RABEP1 835.778192962375 824.3416610084 847.21472491635 1.02774706773884 0.0394852557601182 0.799077662014971 1 4.34556 4.20309 5.06312 3.67309 GeneID:9135,Genbank:NM_004703.5,HGNC:HGNC:17677,MIM:603616 rabaptin, RAB GTPase binding effector protein 1 GO:0005096,GO:0005768,GO:0005769,GO:0006897,GO:0006915,GO:0008083,GO:0015031,GO:0016192,GO:0019904,GO:0030139,GO:0031901,GO:0042803,GO:0043231,GO:0043234,GO:0055037,GO:0061025 GTPase activator activity|endosome|early endosome|endocytosis|apoptotic process|growth factor activity|protein transport|vesicle-mediated transport|protein domain specific binding|endocytic vesicle|early endosome membrane|protein homodimerization activity|intracellular membrane-bounded organelle|protein complex|recycling endosome|membrane fusion hsa04144 Endocytosis RABEP2 434.932474685435 411.892990011626 457.971959359245 1.11187121525501 0.152989694650727 0.410509883125445 1 6.91625 7.13608 8.13801 7.90876 GeneID:79874,Genbank:NM_024816.2,HGNC:HGNC:24817,MIM:611869 rabaptin, RAB GTPase binding effector protein 2 GO:0005096,GO:0005769,GO:0005829,GO:0006897,GO:0008083,GO:0015031,GO:0043231 GTPase activator activity|early endosome|cytosol|endocytosis|growth factor activity|protein transport|intracellular membrane-bounded organelle RABEPK 539.996605542676 586.681733373569 493.311477711783 0.84085024238801 -0.250079219261819 0.142227832968124 1 4.72975 4.63348 3.78732 4.44124 GeneID:10244,Genbank:XM_024447373.1,HGNC:HGNC:16896,MIM:605962 Rab9 effector protein with kelch motifs GO:0005768,GO:0005829,GO:0006898,GO:0006904,GO:0010008,GO:0030133,GO:0032588 endosome|cytosol|receptor-mediated endocytosis|vesicle docking involved in exocytosis|endosome membrane|transport vesicle|trans-Golgi network membrane RABGAP1 933.697817211532 975.636403041713 891.75923138135 0.914028247204735 -0.129689343747911 0.412991435646543 1 4.48969 4.28278 4.20926 3.80878 GeneID:23637,Genbank:XM_017014567.2,HGNC:HGNC:17155,MIM:615882 RAB GTPase activating protein 1 GO:0005096,GO:0005813,GO:0005829,GO:0005875,GO:0006886,GO:0007049,GO:0012505,GO:0015631,GO:0017137,GO:0031338,GO:0043087,GO:0090630 GTPase activator activity|centrosome|cytosol|microtubule associated complex|intracellular protein transport|cell cycle|endomembrane system|tubulin binding|Rab GTPase binding|regulation of vesicle fusion|regulation of GTPase activity|activation of GTPase activity RABGAP1L 124.151417635507 116.471263529872 131.831571741142 1.13188066949519 0.17872186753181 0.504058120207489 1 0.408282 0.307888 0.408581 0.377146 GeneID:9910,Genbank:XM_005245681.2,HGNC:HGNC:24663,MIM:609238 RAB GTPase activating protein 1 like GO:0005096,GO:0005634,GO:0005769,GO:0005794,GO:0006886,GO:0006897,GO:0007049,GO:0017137,GO:0031338,GO:0032880,GO:0090630 GTPase activator activity|nucleus|early endosome|Golgi apparatus|intracellular protein transport|endocytosis|cell cycle|Rab GTPase binding|regulation of vesicle fusion|regulation of protein localization|activation of GTPase activity RABGEF1 829.267672095772 849.171606373955 809.363737817589 0.953121526605972 -0.0692679199400328 0.676606830601888 1 6.09019 5.70701 6.15753 5.3316 GeneID:27342,Genbank:NM_001287060.1,HGNC:HGNC:17676,MIM:609700 RAB guanine nucleotide exchange factor 1 GO:0003677,GO:0005769,GO:0006897,GO:0008270,GO:0015031,GO:0055037 DNA binding|early endosome|endocytosis|zinc ion binding|protein transport|recycling endosome RABGGTA 377.38087283316 360.772693729752 393.989051936569 1.09207004516727 0.127065393413998 0.513009481663518 1 6.55217 6.85557 7.58827 7.36662 GeneID:5875,Genbank:NM_182836.2,HGNC:HGNC:9795,MIM:601905 Rab geranylgeranyltransferase alpha subunit GO:0004663,GO:0005654,GO:0005829,GO:0005886,GO:0005968,GO:0006461,GO:0006464,GO:0007601,GO:0008270,GO:0017137,GO:0018344,GO:0042981,GO:0043687,GO:0046982 Rab geranylgeranyltransferase activity|nucleoplasm|cytosol|plasma membrane|Rab-protein geranylgeranyltransferase complex|protein complex assembly|cellular protein modification process|visual perception|zinc ion binding|Rab GTPase binding|protein geranylgeranylation|regulation of apoptotic process|post-translational protein modification|protein heterodimerization activity RABGGTB 1051.55526146043 1183.72936742569 919.381155495163 0.776681884216986 -0.364604278799579 0.0178081094397031 0.546850871863472 35.1507 31.1621 27.6544 24.5056 GeneID:5876,Genbank:NM_004582.3,HGNC:HGNC:9796,MIM:179080 Rab geranylgeranyltransferase beta subunit RABIF 670.501913365521 697.906290305965 643.097536425078 0.921466886540228 -0.117995772202896 0.475372928967331 1 9.25124 9.49661 8.70553 8.62788 GeneID:5877,Genbank:NM_002871.4,HGNC:HGNC:9797,MIM:603417 RAB interacting factor GO:0005085,GO:0005829,GO:0006892,GO:0007264,GO:0008270,GO:0015031,GO:0016020,GO:0061025 guanyl-nucleotide exchange factor activity|cytosol|post-Golgi vesicle-mediated transport|small GTPase mediated signal transduction|zinc ion binding|protein transport|membrane|membrane fusion RABL2A 73.7546750241289 61.2480995887076 86.2612504595503 1.40839064458833 0.494047549062586 0.143186554270799 1 0.380431 0.399351 0.518714 0.370785 GeneID:11159,Genbank:XM_017003211.1,HGNC:HGNC:9799,MIM:605412 RAB, member of RAS oncogene family like 2A GO:0003924,GO:0005525 GTPase activity|GTP binding RABL2B 234.394521718497 222.604018344809 246.185025092186 1.10593252953255 0.145263372663073 0.527267514796246 1 1.38024 1.58632 1.53211 1.57426 GeneID:11158,Genbank:NM_007081.3,HGNC:HGNC:9800,MIM:605413 RAB, member of RAS oncogene family like 2B GO:0000242,GO:0003924,GO:0005525,GO:0005737,GO:0005814,GO:0036064,GO:0042073,GO:0060271 pericentriolar material|GTPase activity|GTP binding|cytoplasm|centriole|ciliary basal body|intraciliary transport|cilium assembly RABL3 383.452245207877 393.260468082138 373.644022333616 0.950118439709469 -0.0738207269903436 0.702697203873937 1 4.15348 4.08079 3.94488 3.76994 GeneID:285282,Genbank:NM_173825.3,HGNC:HGNC:18072 RAB, member of RAS oncogene family like 3 GO:0005525 GTP binding RABL6 4259.84424849879 3768.94858588467 4750.73991111291 1.26049475148194 0.333990111035212 0.0137072324372384 0.480383008128687 31.8968 34.6251 43.5196 43.3578 GeneID:55684,Genbank:NM_001173988.1,HGNC:HGNC:24703,MIM:610615 RAB, member RAS oncogene family like 6 GO:0003924,GO:0005525,GO:0005634,GO:0005737,GO:0005813,GO:0005829 GTPase activity|GTP binding|nucleus|cytoplasm|centrosome|cytosol RAC1 9091.77037707794 8182.65894325069 10000.8818109052 1.22220440571512 0.289485586670973 0.0269713058142785 0.658377776156645 149.758 157.353 196.434 183.12 GeneID:5879,Genbank:NM_018890.3,HGNC:HGNC:9801,MIM:602048 Rac family small GTPase 1 GO:0000139,GO:0000242,GO:0001891,GO:0001934,GO:0002093,GO:0002551,GO:0003382,GO:0003924,GO:0005525,GO:0005634,GO:0005737,GO:0005802,GO:0005829,GO:0005884,GO:0005886,GO:0005925,GO:0006897,GO:0006911,GO:0006935,GO:0006972,GO:0007010,GO:0007015,GO:0007155,GO:0007186,GO:0007264,GO:0007411,GO:0008283,GO:0008361,GO:0010591,GO:0010592,GO:0010762,GO:0010811,GO:0014041,GO:0016020,GO:0016358,GO:0016477,GO:0016601,GO:0017137,GO:0019897,GO:0019899,GO:0019901,GO:0021799,GO:0021831,GO:0021894,GO:0022604,GO:0030027,GO:0030032,GO:0030036,GO:0030041,GO:0030334,GO:0030742,GO:0030838,GO:0031012,GO:0031116,GO:0031410,GO:0031529,GO:0031901,GO:0031996,GO:0032587,GO:0032707,GO:0034446,GO:0035567,GO:0036464,GO:0042470,GO:0042826,GO:0042995,GO:0043197,GO:0043552,GO:0043652,GO:0045216,GO:0045453,GO:0045740,GO:0048012,GO:0048168,GO:0048532,GO:0048812,GO:0048813,GO:0048870,GO:0048873,GO:0051022,GO:0051117,GO:0051492,GO:0051496,GO:0051668,GO:0051894,GO:0051932,GO:0060071,GO:0060091,GO:0060263,GO:0060999,GO:0070062,GO:0071260,GO:0071526,GO:0071542,GO:0072659,GO:0090023,GO:0090103,GO:0097178,GO:1900026,GO:1904948 Golgi membrane|pericentriolar material|phagocytic cup|positive regulation of protein phosphorylation|auditory receptor cell morphogenesis|mast cell chemotaxis|epithelial cell morphogenesis|GTPase activity|GTP binding|nucleus|cytoplasm|trans-Golgi network|cytosol|actin filament|plasma membrane|focal adhesion|endocytosis|phagocytosis, engulfment|chemotaxis|hyperosmotic response|cytoskeleton organization|actin filament organization|cell adhesion|G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|axon guidance|cell proliferation|regulation of cell size|regulation of lamellipodium assembly|positive regulation of lamellipodium assembly|regulation of fibroblast migration|positive regulation of cell-substrate adhesion|regulation of neuron maturation|membrane|dendrite development|cell migration|Rac protein signal transduction|Rab GTPase binding|extrinsic component of plasma membrane|enzyme binding|protein kinase binding|cerebral cortex radially oriented cell migration|embryonic olfactory bulb interneuron precursor migration|cerebral cortex GABAergic interneuron development|regulation of cell morphogenesis|lamellipodium|lamellipodium assembly|actin cytoskeleton organization|actin filament polymerization|regulation of cell migration|GTP-dependent protein binding|positive regulation of actin filament polymerization|extracellular matrix|positive regulation of microtubule polymerization|cytoplasmic vesicle|ruffle organization|early endosome membrane|thioesterase binding|ruffle membrane|negative regulation of interleukin-23 production|substrate adhesion-dependent cell spreading|non-canonical Wnt signaling pathway|cytoplasmic ribonucleoprotein granule|melanosome|histone deacetylase binding|cell projection|dendritic spine|positive regulation of phosphatidylinositol 3-kinase activity|engulfment of apoptotic cell|cell-cell junction organization|bone resorption|positive regulation of DNA replication|hepatocyte growth factor receptor signaling pathway|regulation of neuronal synaptic plasticity|anatomical structure arrangement|neuron projection morphogenesis|dendrite morphogenesis|cell motility|homeostasis of number of cells within a tissue|Rho GDP-dissociation inhibitor binding|ATPase binding|regulation of stress fiber assembly|positive regulation of stress fiber assembly|localization within membrane|positive regulation of focal adhesion assembly|synaptic transmission, GABAergic|Wnt signaling pathway, planar cell polarity pathway|kinocilium|regulation of respiratory burst|positive regulation of dendritic spine development|extracellular exosome|cellular response to mechanical stimulus|semaphorin-plexin signaling pathway|dopaminergic neuron differentiation|protein localization to plasma membrane|positive regulation of neutrophil chemotaxis|cochlea morphogenesis|ruffle assembly|positive regulation of substrate adhesion-dependent cell spreading|midbrain dopaminergic neuron differentiation hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04071,hsa04145,hsa04151,hsa04310,hsa04360,hsa04370,hsa04380,hsa04510,hsa04520,hsa04530,hsa04620,hsa04650,hsa04662,hsa04664,hsa04666,hsa04670,hsa04722,hsa04810,hsa04932,hsa04933,hsa04972,hsa05014,hsa05100,hsa05120,hsa05131,hsa05132,hsa05163,hsa05167,hsa05169,hsa05170,hsa05200,hsa05203,hsa05205,hsa05210,hsa05211,hsa05212,hsa05231,hsa05416,hsa05418 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Phagosome|PI3K-Akt signaling pathway|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Osteoclast differentiation|Focal adhesion|Adherens junction|Tight junction|Toll-like receptor signaling pathway|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Pancreatic secretion|Amyotrophic lateral sclerosis (ALS)|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Choline metabolism in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis RAC2 3.24325583221799 4.06465003971372 2.42186162472226 0.595835213624648 -0.747014706075989 0.73087828110543 1 0.0896582 0.104611 0.0275656 0.103098 GeneID:5880,Genbank:NM_002872.4,HGNC:HGNC:9802,MIM:602049 Rac family small GTPase 2 hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04071,hsa04310,hsa04360,hsa04370,hsa04510,hsa04520,hsa04650,hsa04662,hsa04664,hsa04666,hsa04670,hsa04810,hsa05163,hsa05170,hsa05200,hsa05210,hsa05212,hsa05231,hsa05416,hsa05418 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis RAC3 345.778130756341 363.472990768071 328.083270744612 0.902634526024406 -0.147786131790599 0.428705612158757 1 12.8635 13.6354 11.5499 12.6405 GeneID:5881,Genbank:NM_001316307.1,HGNC:HGNC:9803,MIM:602050 Rac family small GTPase 3 hsa04010,hsa04014,hsa04015,hsa04024,hsa04071,hsa04310,hsa04360,hsa04370,hsa04510,hsa04520,hsa04650,hsa04662,hsa04664,hsa04810,hsa05163,hsa05170,hsa05200,hsa05210,hsa05212,hsa05231,hsa05416,hsa05418 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Sphingolipid signaling pathway|Wnt signaling pathway|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Natural killer cell mediated cytotoxicity|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Regulation of actin cytoskeleton|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer|Viral myocarditis|Fluid shear stress and atherosclerosis RACGAP1 3575.87764228326 3499.97582144924 3651.77946311729 1.04337276867393 0.0612546856013977 0.64369502590998 1 26.6722 25.9587 29.409 26.3013 GeneID:29127,Genbank:XM_024448958.1,HGNC:HGNC:9804,MIM:604980 Rac GTPase activating protein 1 GO:0000281,GO:0000915,GO:0001669,GO:0005096,GO:0005547,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005874,GO:0006890,GO:0007018,GO:0007283,GO:0007405,GO:0008017,GO:0008272,GO:0019886,GO:0019901,GO:0030496,GO:0031234,GO:0032154,GO:0032467,GO:0035556,GO:0043014,GO:0043015,GO:0045995,GO:0046872,GO:0048487,GO:0051056,GO:0051233,GO:0051256,GO:0051988,GO:0070062,GO:0072686,GO:0090543,GO:0097149 mitotic cytokinesis|actomyosin contractile ring assembly|acrosomal vesicle|GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|nucleus|nucleoplasm|cytoplasm|cytosol|microtubule|retrograde vesicle-mediated transport, Golgi to ER|microtubule-based movement|spermatogenesis|neuroblast proliferation|microtubule binding|sulfate transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|protein kinase binding|midbody|extrinsic component of cytoplasmic side of plasma membrane|cleavage furrow|positive regulation of cytokinesis|intracellular signal transduction|alpha-tubulin binding|gamma-tubulin binding|regulation of embryonic development|metal ion binding|beta-tubulin binding|regulation of small GTPase mediated signal transduction|spindle midzone|mitotic spindle midzone assembly|regulation of attachment of spindle microtubules to kinetochore|extracellular exosome|mitotic spindle|Flemming body|centralspindlin complex RACK1 31785.2835316117 33707.8594384642 29862.7076247591 0.885927143468583 -0.174740035021787 0.168514420509811 1 1068.9 1104.19 932.277 1026.52 GeneID:10399,Genbank:NM_006098.4,HGNC:HGNC:4399,MIM:176981 receptor for activated C kinase 1 GO:0001649,GO:0001891,GO:0001934,GO:0003723,GO:0005080,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006412,GO:0006919,GO:0007049,GO:0007205,GO:0007369,GO:0008200,GO:0008656,GO:0010629,GO:0015935,GO:0016020,GO:0016567,GO:0017148,GO:0019899,GO:0019903,GO:0030178,GO:0030292,GO:0030308,GO:0030332,GO:0030335,GO:0030425,GO:0030496,GO:0030822,GO:0030971,GO:0032436,GO:0032464,GO:0032880,GO:0033137,GO:0035591,GO:0042169,GO:0042803,GO:0042998,GO:0043005,GO:0043022,GO:0043025,GO:0043065,GO:0043204,GO:0043473,GO:0043547,GO:0044297,GO:0045296,GO:0048471,GO:0048511,GO:0050765,GO:0051302,GO:0051343,GO:0051726,GO:0051898,GO:0051901,GO:0070062,GO:0071333,GO:0071363,GO:0072344,GO:1903076,GO:1903208,GO:1990630,GO:2000114,GO:2000543,GO:2001244 osteoblast differentiation|phagocytic cup|positive regulation of protein phosphorylation|RNA binding|protein kinase C binding|nucleus|cytoplasm|mitochondrion|cytosol|translation|activation of cysteine-type endopeptidase activity involved in apoptotic process|cell cycle|protein kinase C-activating G-protein coupled receptor signaling pathway|gastrulation|ion channel inhibitor activity|cysteine-type endopeptidase activator activity involved in apoptotic process|negative regulation of gene expression|small ribosomal subunit|membrane|protein ubiquitination|negative regulation of translation|enzyme binding|protein phosphatase binding|negative regulation of Wnt signaling pathway|protein tyrosine kinase inhibitor activity|negative regulation of cell growth|cyclin binding|positive regulation of cell migration|dendrite|midbody|positive regulation of cAMP catabolic process|receptor tyrosine kinase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein homooligomerization|regulation of protein localization|negative regulation of peptidyl-serine phosphorylation|signaling adaptor activity|SH2 domain binding|protein homodimerization activity|positive regulation of Golgi to plasma membrane protein transport|neuron projection|ribosome binding|neuronal cell body|positive regulation of apoptotic process|perikaryon|pigmentation|positive regulation of GTPase activity|cell body|cadherin binding|perinuclear region of cytoplasm|rhythmic process|negative regulation of phagocytosis|regulation of cell division|positive regulation of cyclic-nucleotide phosphodiesterase activity|regulation of cell cycle|negative regulation of protein kinase B signaling|positive regulation of mitochondrial depolarization|extracellular exosome|cellular response to glucose stimulus|cellular response to growth factor stimulus|rescue of stalled ribosome|regulation of protein localization to plasma membrane|negative regulation of hydrogen peroxide-induced neuron death|IRE1-RACK1-PP2A complex|regulation of establishment of cell polarity|positive regulation of gastrulation|positive regulation of intrinsic apoptotic signaling pathway hsa05162 Measles RAD1 1134.52575902294 1178.60915634376 1090.44236170213 0.925194205248551 -0.112171864889653 0.459630910432372 1 10.3662 10.4923 10.4087 9.27642 GeneID:5810,Genbank:NM_002853.3,HGNC:HGNC:9806,MIM:603153 RAD1 checkpoint DNA exonuclease hsa04218 Cellular senescence RAD17 573.384802076553 597.654392314516 549.115211838589 0.918783863885028 -0.122202575238864 0.486557878591633 1 5.04583 4.9115 5.10285 3.92956 GeneID:5884,Genbank:NM_133343.1,HGNC:HGNC:9807,MIM:603139 RAD17 checkpoint clamp loader component RAD18 562.801379544541 603.593084067797 522.009675021285 0.864837071199199 -0.209499729436253 0.247012200210631 1 4.11027 3.97359 4.09144 2.90099 GeneID:56852,Genbank:NM_020165.3,HGNC:HGNC:18278,MIM:605256 RAD18, E3 ubiquitin protein ligase RAD21 2812.47706136507 2959.24207899751 2665.71204373264 0.900809049266996 -0.150706774499588 0.40210603177375 1 27.8681 25.378 27.2948 20.7613 GeneID:5885,Genbank:NM_006265.2,HGNC:HGNC:9811,MIM:606462 RAD21 cohesin complex component hsa04110 Cell cycle RAD23A 4731.94414440102 4232.93896397952 5230.94932482252 1.23577244305567 0.305413107724784 0.0224683286098839 0.610267415219053 68.972 68.3666 86.506 87.6734 GeneID:5886,Genbank:NM_005053.3,HGNC:HGNC:9812,MIM:600061 RAD23 homolog A, nucleotide excision repair protein hsa03420,hsa04141 Nucleotide excision repair|Protein processing in endoplasmic reticulum RAD23B 3773.83179678065 3981.54112642965 3566.12246713164 0.895663853240033 -0.158970711104011 0.248076580485756 1 38.5841 35.4289 36.7114 30.3704 GeneID:5887,Genbank:NM_002874.4,HGNC:HGNC:9813,MIM:600062 RAD23 homolog B, nucleotide excision repair protein hsa03420,hsa04141 Nucleotide excision repair|Protein processing in endoplasmic reticulum RAD50 223.18221744755 206.882498861742 239.481936033358 1.15757464914131 0.211105232339401 0.707110607897075 1 0.99197 0.736643 1.50531 0.678823 GeneID:10111,Genbank:NM_005732.3,HGNC:HGNC:9816,MIM:604040 RAD50 double strand break repair protein GO:0000019,GO:0000722,GO:0000723,GO:0000724,GO:0000729,GO:0000731,GO:0000732,GO:0000784,GO:0000790,GO:0000794,GO:0003677,GO:0003691,GO:0004017,GO:0005524,GO:0005654,GO:0006260,GO:0006281,GO:0006302,GO:0006303,GO:0006310,GO:0006974,GO:0007004,GO:0007131,GO:0016020,GO:0016032,GO:0016887,GO:0030674,GO:0030870,GO:0031860,GO:0031954,GO:0032206,GO:0032508,GO:0033674,GO:0035861,GO:0043047,GO:0046872,GO:0051880,GO:0070192,GO:0090305,GO:1901796,GO:1904354 regulation of mitotic recombination|telomere maintenance via recombination|telomere maintenance|double-strand break repair via homologous recombination|DNA double-strand break processing|DNA synthesis involved in DNA repair|strand displacement|nuclear chromosome, telomeric region|nuclear chromatin|condensed nuclear chromosome|DNA binding|double-stranded telomeric DNA binding|adenylate kinase activity|ATP binding|nucleoplasm|DNA replication|DNA repair|double-strand break repair|double-strand break repair via nonhomologous end joining|DNA recombination|cellular response to DNA damage stimulus|telomere maintenance via telomerase|reciprocal meiotic recombination|membrane|viral process|ATPase activity|protein binding, bridging|Mre11 complex|telomeric 3' overhang formation|positive regulation of protein autophosphorylation|positive regulation of telomere maintenance|DNA duplex unwinding|positive regulation of kinase activity|site of double-strand break|single-stranded telomeric DNA binding|metal ion binding|G-quadruplex DNA binding|chromosome organization involved in meiotic cell cycle|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator|negative regulation of telomere capping hsa03440,hsa03450,hsa04218 Homologous recombination|Non-homologous end-joining|Cellular senescence RAD51 949.555105851105 1018.59019862544 880.520013076772 0.864449721060553 -0.210146039968387 0.168988812956066 1 11.5206 12.3354 9.92736 10.6373 GeneID:5888,Genbank:XM_011521861.2,HGNC:HGNC:9817,MIM:179617 RAD51 recombinase GO:0000150,GO:0000228,GO:0000400,GO:0000722,GO:0000724,GO:0000730,GO:0000784,GO:0000790,GO:0000794,GO:0000800,GO:0001932,GO:0003682,GO:0003690,GO:0003697,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005759,GO:0005815,GO:0005829,GO:0006268,GO:0006312,GO:0006974,GO:0007131,GO:0008022,GO:0008094,GO:0010212,GO:0010569,GO:0010833,GO:0016605,GO:0035861,GO:0036297,GO:0042148,GO:0042802,GO:0043142,GO:0043234,GO:0048471,GO:0051106,GO:0051260,GO:0070182,GO:0070192,GO:0071479,GO:0072711,GO:0072757,GO:1990414,GO:1990426 recombinase activity|nuclear chromosome|four-way junction DNA binding|telomere maintenance via recombination|double-strand break repair via homologous recombination|DNA recombinase assembly|nuclear chromosome, telomeric region|nuclear chromatin|condensed nuclear chromosome|lateral element|regulation of protein phosphorylation|chromatin binding|double-stranded DNA binding|single-stranded DNA binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrial matrix|microtubule organizing center|cytosol|DNA unwinding involved in DNA replication|mitotic recombination|cellular response to DNA damage stimulus|reciprocal meiotic recombination|protein C-terminus binding|DNA-dependent ATPase activity|response to ionizing radiation|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomere lengthening|PML body|site of double-strand break|interstrand cross-link repair|strand invasion|identical protein binding|single-stranded DNA-dependent ATPase activity|protein complex|perinuclear region of cytoplasm|positive regulation of DNA ligation|protein homooligomerization|DNA polymerase binding|chromosome organization involved in meiotic cell cycle|cellular response to ionizing radiation|cellular response to hydroxyurea|cellular response to camptothecin|replication-born double-strand break repair via sister chromatid exchange|mitotic recombination-dependent replication fork processing hsa03440,hsa03460,hsa05200,hsa05212 Homologous recombination|Fanconi anemia pathway|Pathways in cancer|Pancreatic cancer RAD51AP1 381.328254142401 392.855623573588 369.800884711215 0.941314983217863 -0.0872505359208024 0.81373327424657 1 7.26305 5.01181 6.49206 5.37674 GeneID:10635,Genbank:NM_001130862.1,HGNC:HGNC:16956,MIM:603070 RAD51 associated protein 1 GO:0000724,GO:0000731,GO:0000732,GO:0000790,GO:0003690,GO:0003697,GO:0003723,GO:0005634,GO:0005654,GO:0006281,GO:0010569,GO:0036297,GO:0043234,GO:0071479 double-strand break repair via homologous recombination|DNA synthesis involved in DNA repair|strand displacement|nuclear chromatin|double-stranded DNA binding|single-stranded DNA binding|RNA binding|nucleus|nucleoplasm|DNA repair|regulation of double-strand break repair via homologous recombination|interstrand cross-link repair|protein complex|cellular response to ionizing radiation RAD51AP2 1.26526514449636 1.07619535328461 1.45433493570811 1.35136704620532 0.434419579785585 1 1 0.00593045 0 0.011559 0 GeneID:729475,Genbank:XM_024453116.1,HGNC:HGNC:34417 RAD51 associated protein 2 GO:0043234 protein complex RAD51B 155.795944535635 147.77799832535 163.81389074592 1.10851339578484 0.148626204499834 0.572169016591839 1 0.26431 0.310459 0.395816 0.351774 GeneID:5890,Genbank:NM_001321818.1,HGNC:HGNC:9822,MIM:602948 RAD51 paralog B hsa03440 Homologous recombination RAD51C 741.86362531179 764.515749350879 719.211501272701 0.94074124945543 -0.088130130127525 0.600069762891339 1 7.75338 6.82277 6.96164 6.40248 GeneID:5889,Genbank:XM_006722001.4,HGNC:HGNC:9820,MIM:602774 RAD51 paralog C hsa03440,hsa03460 Homologous recombination|Fanconi anemia pathway RAD51D 507.150782069283 475.87960425823 538.421959880337 1.13142474496169 0.1781406290757 0.312517006633113 1 6.03339 6.81356 7.6655 7.0872 GeneID:5892,Genbank:NM_133629.2,HGNC:HGNC:9823,MIM:602954 RAD51 paralog D hsa03440 Homologous recombination RAD52 126.971563627589 123.09213178385 130.850995471327 1.06303297842872 0.0881863542326723 0.757379699440889 1 0.856513 0.7635 0.930716 0.824584 GeneID:5893,Genbank:XM_017019769.1,HGNC:HGNC:9824,MIM:600392 RAD52 homolog, DNA repair protein hsa03440 Homologous recombination RAD54B 201.848445340808 205.470119585663 198.226771095954 0.964747436248563 -0.0517767899807947 0.862826601855095 1 1.24281 1.01496 1.34207 1.00069 GeneID:25788,Genbank:NM_012415.3,HGNC:HGNC:17228,MIM:604289 RAD54 homolog B GO:0000724,GO:0003677,GO:0003678,GO:0003724,GO:0005524,GO:0005634,GO:0006312,GO:0007131,GO:0015616 double-strand break repair via homologous recombination|DNA binding|DNA helicase activity|RNA helicase activity|ATP binding|nucleus|mitotic recombination|reciprocal meiotic recombination|DNA translocase activity hsa03440 Homologous recombination RAD54L 871.980571258132 853.737153471588 890.223989044676 1.04273778577484 0.0603764131571061 0.71269270658812 1 10.2028 10.6965 11.0228 11.639 GeneID:8438,Genbank:XM_006710975.3,HGNC:HGNC:9826,MIM:603615 RAD54 like hsa03440 Homologous recombination RAD54L2 886.601927511156 888.176421777551 885.027433244761 0.996454546128924 -0.00512409772068503 0.962831390130677 1 2.70237 3.06105 3.37525 2.53196 GeneID:23132,Genbank:NM_001322253.1,HGNC:HGNC:29123 RAD54 like 2 GO:0003677,GO:0004386,GO:0005524,GO:0005634 DNA binding|helicase activity|ATP binding|nucleus RAD9A 250.506152484445 254.351781266705 246.660523702185 0.969761337914693 -0.0442983568373721 0.853033489581388 1 3.39241 2.91437 3.19448 3.23749 GeneID:5883,Genbank:NM_004584.2,HGNC:HGNC:9827,MIM:603761 RAD9 checkpoint clamp component A hsa04218 Cellular senescence RAD9B 28.5888113648421 32.9494367898743 24.22818593981 0.735314114602881 -0.443567416676888 0.420716179097504 1 0.20383 0.187971 0.110136 0.160924 GeneID:144715,Genbank:XM_024448861.1,HGNC:HGNC:21700,MIM:608368 RAD9 checkpoint clamp component B GO:0000076,GO:0005654,GO:0006260,GO:0006281,GO:0008408,GO:0030896,GO:0031573,GO:0071479,GO:0090305,GO:1901796 DNA replication checkpoint|nucleoplasm|DNA replication|DNA repair|3'-5' exonuclease activity|checkpoint clamp complex|intra-S DNA damage checkpoint|cellular response to ionizing radiation|nucleic acid phosphodiester bond hydrolysis|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence RADIL 46.9549298494466 42.0588796732164 51.8509800256768 1.23281885843231 0.30196083604279 0.481052963885371 1 0.592758 0.495346 0.624671 0.651984 GeneID:55698,Genbank:NM_018059.4,HGNC:HGNC:22226,MIM:611491 Rap associating with DIL domain GO:0005874,GO:0007165,GO:0007275,GO:0034446 microtubule|signal transduction|multicellular organism development|substrate adhesion-dependent cell spreading RAE1 1233.97283895061 1316.03883729907 1151.90684060216 0.875283318360298 -0.192178019846512 0.191838462580703 1 15.3164 16.4899 13.8567 14.6814 GeneID:8480,Genbank:NM_003610.3,HGNC:HGNC:9828,MIM:603343 ribonucleic acid export 1 GO:0000972,GO:0001650,GO:0003723,GO:0005634,GO:0005635,GO:0005643,GO:0005737,GO:0006110,GO:0006405,GO:0006406,GO:0006409,GO:0006606,GO:0007077,GO:0008017,GO:0016032,GO:0016925,GO:0019083,GO:0043130,GO:0043657,GO:0051301,GO:0060236,GO:0060964,GO:0071407,GO:0075733,GO:0097431,GO:1900034 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery|fibrillar center|RNA binding|nucleus|nuclear envelope|nuclear pore|cytoplasm|regulation of glycolytic process|RNA export from nucleus|mRNA export from nucleus|tRNA export from nucleus|protein import into nucleus|mitotic nuclear envelope disassembly|microtubule binding|viral process|protein sumoylation|viral transcription|ubiquitin binding|host cell|cell division|regulation of mitotic spindle organization|regulation of gene silencing by miRNA|cellular response to organic cyclic compound|intracellular transport of virus|mitotic spindle pole|regulation of cellular response to heat hsa03013,hsa05164 RNA transport|Influenza A RAET1E 7.74807866764225 8.22535262879733 7.27080470648717 0.883950516726998 -0.177962484626656 0.932555591858282 1 0.0452867 0.042066 0.0501727 0.0201164 GeneID:135250,Genbank:XM_017010286.1,HGNC:HGNC:16793,MIM:609243 retinoic acid early transcript 1E GO:0001913,GO:0005576,GO:0005886,GO:0016021,GO:0042267,GO:0045954,GO:0046703,GO:0050776 T cell mediated cytotoxicity|extracellular region|plasma membrane|integral component of membrane|natural killer cell mediated cytotoxicity|positive regulation of natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity RAET1G 41.4987621937438 35.9859177509883 47.0116066364992 1.30638898698667 0.385584533974058 0.388896609711543 1 0.36357 0.346813 0.637661 0.533904 GeneID:353091,Genbank:NM_001001788.3,HGNC:HGNC:16795,MIM:609244 retinoic acid early transcript 1G GO:0002729,GO:0005576,GO:0005783,GO:0005886,GO:0006501,GO:0016021,GO:0016032,GO:0031225,GO:0042267,GO:0046703 positive regulation of natural killer cell cytokine production|extracellular region|endoplasmic reticulum|plasma membrane|C-terminal protein lipidation|integral component of membrane|viral process|anchored component of membrane|natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding hsa04650 Natural killer cell mediated cytotoxicity RAET1L 7.72439214985138 8.66739775606975 6.78138654363301 0.782401677468191 -0.354018631457585 0.782496163828464 1 0.200289 0.261097 0.0540485 0.226681 GeneID:154064,Genbank:XM_011535486.2,HGNC:HGNC:16798,MIM:611047 retinoic acid early transcript 1L GO:0005576,GO:0005783,GO:0005886,GO:0006501,GO:0016032,GO:0031225,GO:0042267,GO:0046703 extracellular region|endoplasmic reticulum|plasma membrane|C-terminal protein lipidation|viral process|anchored component of membrane|natural killer cell mediated cytotoxicity|natural killer cell lectin-like receptor binding hsa04650 Natural killer cell mediated cytotoxicity RAF1 4381.89021237205 4172.22692806575 4591.55349667834 1.10050425728089 0.138164726280041 0.300304787230208 1 37.7313 37.9916 45.5168 39.4989 GeneID:5894,Genbank:NM_001354695.1,HGNC:HGNC:9829,MIM:164760 Raf-1 proto-oncogene, serine/threonine kinase hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04068,hsa04071,hsa04072,hsa04140,hsa04150,hsa04151,hsa04210,hsa04218,hsa04270,hsa04360,hsa04370,hsa04371,hsa04510,hsa04540,hsa04550,hsa04625,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04720,hsa04722,hsa04726,hsa04730,hsa04810,hsa04910,hsa04912,hsa04914,hsa04915,hsa04916,hsa04917,hsa04919,hsa04921,hsa04926,hsa04928,hsa05034,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05167,hsa05170,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05213,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|Apoptosis|Cellular senescence|Vascular smooth muscle contraction|Axon guidance|VEGF signaling pathway|Apelin signaling pathway|Focal adhesion|Gap junction|Signaling pathways regulating pluripotency of stem cells|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Long-term potentiation|Neurotrophin signaling pathway|Serotonergic synapse|Long-term depression|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Progesterone-mediated oocyte maturation|Estrogen signaling pathway|Melanogenesis|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Parathyroid hormone synthesis, secretion and action|Alcoholism|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Choline metabolism in cancer RAG1 21.0104658308877 24.0899339350647 17.9309977267107 0.744335695359081 -0.425974671400323 0.508273456099345 1 0.134437 0.133106 0.104075 0.0797273 GeneID:5896,Genbank:XM_011520250.2,HGNC:HGNC:9831,MIM:179615 recombination activating 1 hsa04068,hsa05340 FoxO signaling pathway|Primary immunodeficiency RAI1 1605.55474403926 1571.1042550335 1640.00523304501 1.04385512787631 0.0619215004161502 0.70307808244648 1 5.8076 6.57176 6.78346 6.38239 GeneID:10743,Genbank:XM_017024025.1,HGNC:HGNC:9834,MIM:607642 retinoic acid induced 1 GO:0001501,GO:0003700,GO:0005634,GO:0005654,GO:0005739,GO:0032922,GO:0035326,GO:0040015,GO:0045893,GO:0045944,GO:0046872 skeletal system development|DNA binding transcription factor activity|nucleus|nucleoplasm|mitochondrion|circadian regulation of gene expression|enhancer binding|negative regulation of multicellular organism growth|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding RAI14 1431.22450653498 1430.19096298553 1432.25805008442 1.00144532244461 0.00208365410976158 0.970183628938889 1 7.05378 5.7398 7.63464 5.39324 GeneID:26064,Genbank:XM_017009336.2,HGNC:HGNC:14873,MIM:606586 retinoic acid induced 14 GO:0001650,GO:0005634,GO:0005739,GO:0005829,GO:0005856,GO:0005938,GO:0007283,GO:0030054,GO:0030154 fibrillar center|nucleus|mitochondrion|cytosol|cytoskeleton|cell cortex|spermatogenesis|cell junction|cell differentiation RAI2 5.3966119711209 3.03648096111406 7.75674298112774 2.5545172456085 1.35305067544005 0.329923384707368 1 0.0327 0.0581957 0.152348 0.0570858 GeneID:10742,Genbank:XM_006724459.2,HGNC:HGNC:9835,MIM:300217 retinoic acid induced 2 GO:0009790 embryo development RALA 1505.26925295454 1602.60781857855 1407.93068733052 0.878524783798507 -0.186845108643634 0.206049363718626 1 16.1201 14.7462 15.1011 12.6528 GeneID:5898,Genbank:XM_011515467.1,HGNC:HGNC:9839,MIM:179550 RAS like proto-oncogene A GO:0001843,GO:0003924,GO:0005525,GO:0005886,GO:0005925,GO:0006887,GO:0006935,GO:0007049,GO:0007165,GO:0007265,GO:0009986,GO:0016032,GO:0017022,GO:0017157,GO:0019003,GO:0030659,GO:0031532,GO:0031625,GO:0031755,GO:0032154,GO:0035722,GO:0043209,GO:0051117,GO:0051301,GO:0051491,GO:0051665,GO:0061024,GO:0070062,GO:0090543 neural tube closure|GTPase activity|GTP binding|plasma membrane|focal adhesion|exocytosis|chemotaxis|cell cycle|signal transduction|Ras protein signal transduction|cell surface|viral process|myosin binding|regulation of exocytosis|GDP binding|cytoplasmic vesicle membrane|actin cytoskeleton reorganization|ubiquitin protein ligase binding|Edg-2 lysophosphatidic acid receptor binding|cleavage furrow|interleukin-12-mediated signaling pathway|myelin sheath|ATPase binding|cell division|positive regulation of filopodium assembly|membrane raft localization|membrane organization|extracellular exosome|Flemming body hsa04014,hsa04015,hsa04072,hsa05200,hsa05210,hsa05212 Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Pathways in cancer|Colorectal cancer|Pancreatic cancer RALB 744.348333663848 788.894857934908 699.801809392787 0.887066004238713 -0.172886639239153 0.279166427383747 1 11.1406 11.5489 11.0087 10.3605 GeneID:5899,Genbank:NM_002881.2,HGNC:HGNC:9840,MIM:179551 RAS like proto-oncogene B GO:0001928,GO:0001934,GO:0003924,GO:0005525,GO:0005622,GO:0005886,GO:0006915,GO:0007049,GO:0007165,GO:0007265,GO:0009267,GO:0019003,GO:0030496,GO:0031625,GO:0032091,GO:0032092,GO:0051117,GO:0051301,GO:0060178,GO:0070062,GO:0071360,GO:0071902,GO:2000786 regulation of exocyst assembly|positive regulation of protein phosphorylation|GTPase activity|GTP binding|intracellular|plasma membrane|apoptotic process|cell cycle|signal transduction|Ras protein signal transduction|cellular response to starvation|GDP binding|midbody|ubiquitin protein ligase binding|negative regulation of protein binding|positive regulation of protein binding|ATPase binding|cell division|regulation of exocyst localization|extracellular exosome|cellular response to exogenous dsRNA|positive regulation of protein serine/threonine kinase activity|positive regulation of autophagosome assembly hsa04014,hsa04015,hsa04072,hsa05200,hsa05210,hsa05212 Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Pathways in cancer|Colorectal cancer|Pancreatic cancer RALBP1 2624.15870335836 2559.51869814397 2688.79870857275 1.05050950029102 0.0710892090940319 0.606813787186781 1 21.6197 21.9207 24.3772 21.8193 GeneID:10928,Genbank:NM_006788.3,HGNC:HGNC:9841,MIM:605801 ralA binding protein 1 GO:0005096,GO:0005829,GO:0006855,GO:0006897,GO:0006935,GO:0007165,GO:0007264,GO:0015238,GO:0016020,GO:0017160,GO:0022857,GO:0043087,GO:0043492,GO:0043547,GO:0048365,GO:0051056,GO:0055085,GO:1900753 GTPase activator activity|cytosol|drug transmembrane transport|endocytosis|chemotaxis|signal transduction|small GTPase mediated signal transduction|drug transmembrane transporter activity|membrane|Ral GTPase binding|transmembrane transporter activity|regulation of GTPase activity|ATPase activity, coupled to movement of substances|positive regulation of GTPase activity|Rac GTPase binding|regulation of small GTPase mediated signal transduction|transmembrane transport|doxorubicin transport hsa04014,hsa05200,hsa05212 Ras signaling pathway|Pathways in cancer|Pancreatic cancer RALGAPA1 129.355728755665 121.525865028608 137.185592482723 1.1288592140482 0.174865571266369 0.696332284887838 1 0.301471 0.310677 0.448779 0.245863 GeneID:253959,Genbank:NM_194301.3,HGNC:HGNC:17770,MIM:608884 Ral GTPase activating protein catalytic alpha subunit 1 GO:0005096,GO:0005634,GO:0005737,GO:0046982,GO:0051056,GO:0090630 GTPase activator activity|nucleus|cytoplasm|protein heterodimerization activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity RALGAPA2 593.049894856504 555.020214345935 631.079575367074 1.13703890246731 0.185281615212168 0.474288779437535 1 1.30182 1.47765 1.96062 1.27739 GeneID:57186,Genbank:XM_006723598.1,HGNC:HGNC:16207 Ral GTPase activating protein catalytic alpha subunit 2 GO:0005096,GO:0005615,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0046982,GO:0051056,GO:0090630 GTPase activator activity|extracellular space|nucleus|cytoplasm|cytosol|plasma membrane|protein heterodimerization activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity RALGAPB 1360.90540856196 1403.48900990812 1318.3218072158 0.939317513645583 -0.0903151862814705 0.600203245708519 1 5.68485 5.14901 5.96272 4.45197 GeneID:57148,Genbank:NM_020336.3,HGNC:HGNC:29221 Ral GTPase activating protein non-catalytic beta subunit GO:0005096,GO:0046982,GO:0051056,GO:0090630 GTPase activator activity|protein heterodimerization activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity RALGDS 478.528841493318 485.075291035834 471.982391950802 0.97300852192023 -0.0394756542404665 0.826502054894602 1 4.1563 3.8453 3.42664 4.22127 GeneID:5900,Genbank:NM_001042368.2,HGNC:HGNC:9842,MIM:601619 ral guanine nucleotide dissociation stimulator GO:0005085,GO:0005634,GO:0005829,GO:0005903,GO:0007265,GO:0030695 guanyl-nucleotide exchange factor activity|nucleus|cytosol|brush border|Ras protein signal transduction|GTPase regulator activity hsa04014,hsa04015,hsa04072,hsa05200,hsa05210,hsa05212,hsa05231 Ras signaling pathway|Rap1 signaling pathway|Phospholipase D signaling pathway|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Choline metabolism in cancer RALGPS1 130.424951426328 118.835376645397 142.014526207259 1.1950526031573 0.257074123347359 0.344839279341277 1 0.257055 0.285822 0.376147 0.244422 GeneID:9649,Genbank:NM_001322321.1,HGNC:HGNC:16851,MIM:614444 Ral GEF with PH domain and SH3 binding motif 1 GO:0005737,GO:0005886,GO:0007264,GO:0008321,GO:0032485 cytoplasm|plasma membrane|small GTPase mediated signal transduction|Ral guanyl-nucleotide exchange factor activity|regulation of Ral protein signal transduction RALGPS2 253.330929600718 284.206902165672 222.454957035764 0.782721866853495 -0.353428344963663 0.0988379867167959 1 1.61577 1.455 1.37318 1.12347 GeneID:55103,Genbank:NM_152663.4,HGNC:HGNC:30279,MIM:617819 Ral GEF with PH domain and SH3 binding motif 2 GO:0005085,GO:0005737,GO:0005886,GO:0007264,GO:0032485 guanyl-nucleotide exchange factor activity|cytoplasm|plasma membrane|small GTPase mediated signal transduction|regulation of Ral protein signal transduction RALY 4706.96155667305 4292.53658692044 5121.38652642566 1.19309094348334 0.254704016806636 0.0590820778432278 0.879410748501007 25.6784 27.3088 32.004 32.7036 GeneID:22913,Genbank:NM_016732.2,HGNC:HGNC:15921,MIM:614663 RALY heterogeneous nuclear ribonucleoprotein GO:0000398,GO:0003712,GO:0003723,GO:0005634,GO:0006351,GO:0006355,GO:0071013,GO:1903506,GO:2000188 mRNA splicing, via spliceosome|transcription cofactor activity|RNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|catalytic step 2 spliceosome|regulation of nucleic acid-templated transcription|regulation of cholesterol homeostasis RALYL 0.975139704544532 0.980142803914724 0.97013660517434 0.989791080748215 -0.0148040531050533 1 1 0 0 0.00642967 0 GeneID:138046,Genbank:XM_024447066.1,HGNC:HGNC:27036,MIM:614648 RALY RNA binding protein like GO:0003723,GO:0005634,GO:0042802 RNA binding|nucleus|identical protein binding RAMP1 10.512900874275 13.7602168743831 7.26558487416678 0.528013834410767 -0.921352364973452 0.309512738835149 1 0.136264 0.133766 0.0537394 0.0836938 GeneID:10267,Genbank:XM_017003153.2,HGNC:HGNC:9843,MIM:605153 receptor activity modifying protein 1 GO:0001525,GO:0001635,GO:0004872,GO:0005615,GO:0005622,GO:0005886,GO:0005887,GO:0006816,GO:0006886,GO:0007186,GO:0007189,GO:0008277,GO:0008565,GO:0009986,GO:0015026,GO:0015031,GO:0030816,GO:0031623,GO:0043235,GO:0060050,GO:0072659,GO:0097647,GO:1903440,GO:1990406,GO:1990407,GO:1990408 angiogenesis|calcitonin gene-related peptide receptor activity|receptor activity|extracellular space|intracellular|plasma membrane|integral component of plasma membrane|calcium ion transport|intracellular protein transport|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|protein transporter activity|cell surface|coreceptor activity|protein transport|positive regulation of cAMP metabolic process|receptor internalization|receptor complex|positive regulation of protein glycosylation|protein localization to plasma membrane|amylin receptor signaling pathway|amylin receptor complex|CGRP receptor complex|calcitonin gene-related peptide binding|calcitonin gene-related peptide receptor signaling pathway hsa04270 Vascular smooth muscle contraction RAMP2 8.7079064755046 11.1177547658566 6.29805818515264 0.566486517987825 -0.819886473640437 0.414027878413508 1 0.515971 0.855294 0.207377 0.515608 GeneID:10266,Genbank:NM_005854.2,HGNC:HGNC:9844,MIM:605154 receptor activity modifying protein 2 GO:0001525,GO:0001570,GO:0001605,GO:0001666,GO:0002040,GO:0005737,GO:0005764,GO:0005886,GO:0005887,GO:0005905,GO:0006816,GO:0006886,GO:0007186,GO:0007189,GO:0007507,GO:0007565,GO:0008217,GO:0008277,GO:0008565,GO:0009986,GO:0010628,GO:0015026,GO:0015031,GO:0030816,GO:0031623,GO:0032355,GO:0032570,GO:0032870,GO:0034333,GO:0035924,GO:0043116,GO:0043235,GO:0045766,GO:0070830,GO:0070831,GO:0072659,GO:0097084,GO:0097647,GO:1903143,GO:1903440,GO:1990409,GO:1990410,GO:2000352,GO:2001214 angiogenesis|vasculogenesis|adrenomedullin receptor activity|response to hypoxia|sprouting angiogenesis|cytoplasm|lysosome|plasma membrane|integral component of plasma membrane|clathrin-coated pit|calcium ion transport|intracellular protein transport|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|heart development|female pregnancy|regulation of blood pressure|regulation of G-protein coupled receptor protein signaling pathway|protein transporter activity|cell surface|positive regulation of gene expression|coreceptor activity|protein transport|positive regulation of cAMP metabolic process|receptor internalization|response to estradiol|response to progesterone|cellular response to hormone stimulus|adherens junction assembly|cellular response to vascular endothelial growth factor stimulus|negative regulation of vascular permeability|receptor complex|positive regulation of angiogenesis|bicellular tight junction assembly|basement membrane assembly|protein localization to plasma membrane|vascular smooth muscle cell development|amylin receptor signaling pathway|adrenomedullin receptor complex|amylin receptor complex|adrenomedullin binding|adrenomedullin receptor signaling pathway|negative regulation of endothelial cell apoptotic process|positive regulation of vasculogenesis hsa04270 Vascular smooth muscle contraction RAN 11815.1884356982 12717.7365545153 10912.6403168811 0.858064661907677 -0.220841724670137 0.0870639277900504 0.967672357727583 173.133 187.681 147.667 164.211 GeneID:5901,Genbank:XM_017019772.1,HGNC:HGNC:9846,MIM:601179 RAN, member RAS oncogene family GO:0000054,GO:0000055,GO:0000056,GO:0000060,GO:0000070,GO:0000226,GO:0000287,GO:0000785,GO:0001673,GO:0002177,GO:0003723,GO:0003924,GO:0005487,GO:0005525,GO:0005634,GO:0005635,GO:0005643,GO:0005654,GO:0005730,GO:0005737,GO:0005814,GO:0006606,GO:0006611,GO:0006913,GO:0007286,GO:0014070,GO:0016020,GO:0019003,GO:0019904,GO:0021766,GO:0030036,GO:0030496,GO:0031012,GO:0032092,GO:0032403,GO:0034613,GO:0034629,GO:0036126,GO:0042470,GO:0042565,GO:0043234,GO:0043393,GO:0045296,GO:0045505,GO:0046039,GO:0046982,GO:0051301,GO:0055037,GO:0061015,GO:0061676,GO:0070062,GO:0070883,GO:0071389,GO:1902570 ribosomal subunit export from nucleus|ribosomal large subunit export from nucleus|ribosomal small subunit export from nucleus|protein import into nucleus, translocation|mitotic sister chromatid segregation|microtubule cytoskeleton organization|magnesium ion binding|chromatin|male germ cell nucleus|manchette|RNA binding|GTPase activity|nucleocytoplasmic transporter activity|GTP binding|nucleus|nuclear envelope|nuclear pore|nucleoplasm|nucleolus|cytoplasm|centriole|protein import into nucleus|protein export from nucleus|nucleocytoplasmic transport|spermatid development|response to organic cyclic compound|membrane|GDP binding|protein domain specific binding|hippocampus development|actin cytoskeleton organization|midbody|extracellular matrix|positive regulation of protein binding|protein complex binding|cellular protein localization|cellular protein complex localization|sperm flagellum|melanosome|RNA nuclear export complex|protein complex|regulation of protein binding|cadherin binding|dynein intermediate chain binding|GTP metabolic process|protein heterodimerization activity|cell division|recycling endosome|snRNA import into nucleus|importin-alpha family protein binding|extracellular exosome|pre-miRNA binding|cellular response to mineralocorticoid stimulus|protein localization to nucleolus hsa03008,hsa03013,hsa05166 Ribosome biogenesis in eukaryotes|RNA transport|Human T-cell leukemia virus 1 infection RANBP1 4277.9311548272 4580.19157220832 3975.67073744609 0.868014072068439 -0.204209663348036 0.124150084227224 1 15.3562 15.2832 14.1357 15.4134 GeneID:5902,Genbank:NM_001278639.1,HGNC:HGNC:9847,MIM:601180 RAN binding protein 1 GO:0000082,GO:0005092,GO:0005096,GO:0005634,GO:0005635,GO:0005737,GO:0005813,GO:0005829,GO:0006405,GO:0006511,GO:0006606,GO:0007051,GO:0007165,GO:0008536,GO:0016032,GO:0045296,GO:0046604,GO:0046907 G1/S transition of mitotic cell cycle|GDP-dissociation inhibitor activity|GTPase activator activity|nucleus|nuclear envelope|cytoplasm|centrosome|cytosol|RNA export from nucleus|ubiquitin-dependent protein catabolic process|protein import into nucleus|spindle organization|signal transduction|Ran GTPase binding|viral process|cadherin binding|positive regulation of mitotic centrosome separation|intracellular transport hsa05166,hsa05203 Human T-cell leukemia virus 1 infection|Viral carcinogenesis RANBP10 700.749821133957 645.979356009555 755.52028625836 1.1695734224782 0.225982432806414 0.167845394349784 1 3.3339 3.32925 3.94759 3.95649 GeneID:57610,Genbank:NM_001320238.1,HGNC:HGNC:29285,MIM:614031 RAN binding protein 10 GO:0005634,GO:0005829 nucleus|cytosol RANBP2 250.003548064239 246.000950123214 254.006146005265 1.032541320991 0.0461995176214328 0.902733755125773 1 0.645631 0.506129 0.763986 0.416851 GeneID:5903,Genbank:XM_017004623.2,HGNC:HGNC:9848,MIM:601181 RAN binding protein 2 hsa03013 RNA transport RANBP3 2138.73401838018 2008.02808716368 2269.43994959668 1.13018336949771 0.176556865386339 0.2188686294456 1 16.0732 17.5883 18.5983 19.5596 GeneID:8498,Genbank:NM_001300865.1,HGNC:HGNC:9850,MIM:603327 RAN binding protein 3 GO:0005634,GO:0005737,GO:0015031,GO:0046907 nucleus|cytoplasm|protein transport|intracellular transport hsa05166 Human T-cell leukemia virus 1 infection RANBP3L 23.4789259794186 17.8728931887818 29.0849587700555 1.62732236257704 0.702500068357936 0.241350534228663 1 0.0790427 0.140899 0.238483 0.143253 GeneID:202151,Genbank:NM_145000.4,HGNC:HGNC:26353,MIM:616391 RAN binding protein 3 like GO:0000082,GO:0005634,GO:0005737,GO:0005813,GO:0006405,GO:0006511,GO:0006606,GO:0007051,GO:0008536,GO:0043547,GO:0045663,GO:0045668,GO:0046332,GO:0046604,GO:0046907,GO:1901706 G1/S transition of mitotic cell cycle|nucleus|cytoplasm|centrosome|RNA export from nucleus|ubiquitin-dependent protein catabolic process|protein import into nucleus|spindle organization|Ran GTPase binding|positive regulation of GTPase activity|positive regulation of myoblast differentiation|negative regulation of osteoblast differentiation|SMAD binding|positive regulation of mitotic centrosome separation|intracellular transport|mesenchymal cell differentiation involved in bone development RANBP6 376.953378879507 382.621959062276 371.284798696739 0.97036981256036 -0.0433934248358655 0.941014339843591 1 4.19036 3.00669 4.24146 2.81367 GeneID:26953,Genbank:NM_001243203.1,HGNC:HGNC:9851 RAN binding protein 6 GO:0000060,GO:0005737,GO:0006607,GO:0006610,GO:0008139,GO:0008565,GO:0031965,GO:0034399 protein import into nucleus, translocation|cytoplasm|NLS-bearing protein import into nucleus|ribosomal protein import into nucleus|nuclear localization sequence binding|protein transporter activity|nuclear membrane|nuclear periphery RANBP9 1765.59662280641 1767.52952431816 1763.66372129466 0.997812877821662 -0.00315880592831715 0.988296341099122 1 16.8469 16.4729 18.1271 14.9995 GeneID:10048,Genbank:XM_011514205.2,HGNC:HGNC:13727,MIM:603854 RAN binding protein 9 RANGAP1 6426.39351838798 6717.04079450188 6135.74624227409 0.913459725791215 -0.130586972692676 0.308443529818847 1 24.0931 26.7293 23.6118 23.8858 GeneID:5905,Genbank:NM_001317930.1,HGNC:HGNC:9854,MIM:602362 Ran GTPase activating protein 1 GO:0000777,GO:0000922,GO:0003723,GO:0005096,GO:0005635,GO:0005643,GO:0005737,GO:0005829,GO:0007062,GO:0007165,GO:0008536,GO:0016235,GO:0016925,GO:0030425,GO:0031625,GO:0031965,GO:0043231,GO:0044614,GO:0045296,GO:0046826,GO:0048471,GO:0048678,GO:0072686,GO:0090630,GO:1904115,GO:1904117,GO:1990723 condensed chromosome kinetochore|spindle pole|RNA binding|GTPase activator activity|nuclear envelope|nuclear pore|cytoplasm|cytosol|sister chromatid cohesion|signal transduction|Ran GTPase binding|aggresome|protein sumoylation|dendrite|ubiquitin protein ligase binding|nuclear membrane|intracellular membrane-bounded organelle|nuclear pore cytoplasmic filaments|cadherin binding|negative regulation of protein export from nucleus|perinuclear region of cytoplasm|response to axon injury|mitotic spindle|activation of GTPase activity|axon cytoplasm|cellular response to vasopressin|cytoplasmic periphery of the nuclear pore complex hsa03013 RNA transport RANGRF 860.456817649673 843.331001171753 877.582634127594 1.04061469684887 0.0574359880963248 0.780680094996125 1 18.1088 19.9174 18.7401 21.7309 GeneID:29098,Genbank:NM_001330127.1,HGNC:HGNC:17679,MIM:607954 RAN guanine nucleotide release factor GO:0002027,GO:0003254,GO:0005085,GO:0005087,GO:0005634,GO:0005654,GO:0005737,GO:0005791,GO:0005829,GO:0005886,GO:0005901,GO:0006888,GO:0008536,GO:0008565,GO:0014704,GO:0017080,GO:0032527,GO:0042391,GO:0044325,GO:0048471,GO:0090226,GO:0098905,GO:0098909,GO:1900825,GO:1902305,GO:1903078,GO:2000010,GO:2000649 regulation of heart rate|regulation of membrane depolarization|guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity|nucleus|nucleoplasm|cytoplasm|rough endoplasmic reticulum|cytosol|plasma membrane|caveola|ER to Golgi vesicle-mediated transport|Ran GTPase binding|protein transporter activity|intercalated disc|sodium channel regulator activity|protein exit from endoplasmic reticulum|regulation of membrane potential|ion channel binding|perinuclear region of cytoplasm|regulation of microtubule nucleation by Ran protein signal transduction|regulation of bundle of His cell action potential|regulation of cardiac muscle cell action potential involved in regulation of contraction|regulation of membrane depolarization during cardiac muscle cell action potential|regulation of sodium ion transmembrane transport|positive regulation of protein localization to plasma membrane|positive regulation of protein localization to cell surface|regulation of sodium ion transmembrane transporter activity RAP1A 786.405608809821 824.00446008475 748.806757534892 0.908741146204325 -0.138058691854402 0.509429457379689 1 3.64679 3.0946 3.35186 2.71435 GeneID:5906,Genbank:XM_017001964.1,HGNC:HGNC:9855,MIM:179520 RAP1A, member of RAS oncogene family GO:0003924,GO:0005525,GO:0005737,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0007264,GO:0008565,GO:0009743,GO:0010976,GO:0015031,GO:0017016,GO:0017034,GO:0030054,GO:0032045,GO:0032403,GO:0032486,GO:0032966,GO:0035690,GO:0038180,GO:0043005,GO:0043209,GO:0043547,GO:0045335,GO:0045860,GO:0046326,GO:0048471,GO:0061028,GO:0070062,GO:0070374,GO:0071320,GO:0071333,GO:0071407,GO:0097327,GO:0097421,GO:1901888,GO:1905451,GO:1990090,GO:2000301,GO:2001214 GTPase activity|GTP binding|cytoplasm|early endosome|late endosome|cytosol|plasma membrane|small GTPase mediated signal transduction|protein transporter activity|response to carbohydrate|positive regulation of neuron projection development|protein transport|Ras GTPase binding|Rap guanyl-nucleotide exchange factor activity|cell junction|guanyl-nucleotide exchange factor complex|protein complex binding|Rap protein signal transduction|negative regulation of collagen biosynthetic process|cellular response to drug|nerve growth factor signaling pathway|neuron projection|myelin sheath|positive regulation of GTPase activity|phagocytic vesicle|positive regulation of protein kinase activity|positive regulation of glucose import|perinuclear region of cytoplasm|establishment of endothelial barrier|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|cellular response to glucose stimulus|cellular response to organic cyclic compound|response to antineoplastic agent|liver regeneration|regulation of cell junction assembly|positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis|cellular response to nerve growth factor stimulus|negative regulation of synaptic vesicle exocytosis|positive regulation of vasculogenesis hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04510,hsa04530,hsa04611,hsa04670,hsa04720,hsa04722,hsa04934,hsa04972,hsa05211 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Long-term potentiation|Neurotrophin signaling pathway|Cushing syndrome|Pancreatic secretion|Renal cell carcinoma RAP1B 2153.59881135609 2268.36048445322 2038.83713825897 0.898815312747976 -0.153903391556255 0.289131232987114 1 46.7676 41.6642 42.094 38.6532 GeneID:5908,Genbank:NM_015646.5,HGNC:HGNC:9857,MIM:179530 RAP1B, member of RAS oncogene family GO:0003924,GO:0005525,GO:0005622,GO:0005811,GO:0005829,GO:0005886,GO:0005911,GO:0007264,GO:0008283,GO:0019003,GO:0032403,GO:0032486,GO:0045955,GO:0061028,GO:0070374,GO:0071320,GO:1901888,GO:2000114,GO:2000301 GTPase activity|GTP binding|intracellular|lipid droplet|cytosol|plasma membrane|cell-cell junction|small GTPase mediated signal transduction|cell proliferation|GDP binding|protein complex binding|Rap protein signal transduction|negative regulation of calcium ion-dependent exocytosis|establishment of endothelial barrier|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|regulation of cell junction assembly|regulation of establishment of cell polarity|negative regulation of synaptic vesicle exocytosis hsa04010,hsa04014,hsa04015,hsa04024,hsa04062,hsa04510,hsa04611,hsa04670,hsa04720,hsa04722,hsa04934,hsa04972,hsa05211 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Focal adhesion|Platelet activation|Leukocyte transendothelial migration|Long-term potentiation|Neurotrophin signaling pathway|Cushing syndrome|Pancreatic secretion|Renal cell carcinoma RAP1GAP 23.8357851334561 21.9855695031805 25.6860007637317 1.16831182198923 0.224425380380509 0.734426302037313 1 0.158423 0.146534 0.146804 0.171459 GeneID:5909,Genbank:XM_017001965.1,HGNC:HGNC:9858,MIM:600278 RAP1 GTPase activating protein hsa04015 Rap1 signaling pathway RAP1GAP2 93.9369900726459 102.576776486542 85.2972036587498 0.831544981041013 -0.266133789078236 0.389230614447763 1 0.451714 0.475633 0.426215 0.360444 GeneID:23108,Genbank:XM_011523738.2,HGNC:HGNC:29176 RAP1 GTPase activating protein 2 GO:0005096,GO:0005813,GO:0005829,GO:0005886,GO:0008361,GO:0010977,GO:0031965,GO:0043005,GO:0048471,GO:0051056 GTPase activator activity|centrosome|cytosol|plasma membrane|regulation of cell size|negative regulation of neuron projection development|nuclear membrane|neuron projection|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction RAP1GDS1 726.512708186171 778.843489867229 674.181926505113 0.865619261477094 -0.208195492986598 0.197275212256224 1 6.37448 6.50044 6.30256 5.17914 GeneID:5910,Genbank:NM_001100426.1,HGNC:HGNC:9859,MIM:179502 Rap1 GTPase-GDP dissociation stimulator 1 GO:0005096,GO:0005829,GO:0007264,GO:0043547 GTPase activator activity|cytosol|small GTPase mediated signal transduction|positive regulation of GTPase activity RAP2A 459.281993703688 478.953285838066 439.610701569311 0.917857157614205 -0.123658444555823 0.626228169353366 1 5.72793 4.83341 5.66583 4.16443 GeneID:5911,Genbank:NM_021033.6,HGNC:HGNC:9861,MIM:179540 RAP2A, member of RAS oncogene family RAP2B 920.254092413916 941.467709075355 899.040475752478 0.954935009545313 -0.0665255445632598 0.663022849020622 1 5.57624 6.10102 6.15301 5.09865 GeneID:5912,Genbank:NM_002886.3,HGNC:HGNC:9862,MIM:179541 RAP2B, member of RAS oncogene family GO:0003924,GO:0005525,GO:0005829,GO:0005886,GO:0005923,GO:0016020,GO:0019003,GO:0019904,GO:0030168,GO:0030336,GO:0031954,GO:0032486,GO:0044291,GO:0045121,GO:0055037,GO:0055038,GO:0061097,GO:0070062,GO:0070527 GTPase activity|GTP binding|cytosol|plasma membrane|bicellular tight junction|membrane|GDP binding|protein domain specific binding|platelet activation|negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|cell-cell contact zone|membrane raft|recycling endosome|recycling endosome membrane|regulation of protein tyrosine kinase activity|extracellular exosome|platelet aggregation RAP2C 946.580521699574 950.902510225529 942.25853317362 0.990909712658284 -0.0131744835242326 0.97048266367161 1 12.1865 11.7959 14.3538 9.69002 GeneID:57826,Genbank:NM_001271187.1,HGNC:HGNC:21165 RAP2C, member of RAS oncogene family GO:0003713,GO:0003924,GO:0005525,GO:0005737,GO:0005829,GO:0005886,GO:0005923,GO:0016020,GO:0019003,GO:0030336,GO:0031954,GO:0032486,GO:0044291,GO:0055037,GO:0055038,GO:0061097,GO:0090557 transcription coactivator activity|GTPase activity|GTP binding|cytoplasm|cytosol|plasma membrane|bicellular tight junction|membrane|GDP binding|negative regulation of cell migration|positive regulation of protein autophosphorylation|Rap protein signal transduction|cell-cell contact zone|recycling endosome|recycling endosome membrane|regulation of protein tyrosine kinase activity|establishment of endothelial intestinal barrier hsa04530 Tight junction RAPGEF1 3601.48555048465 2913.31675638845 4289.65434458085 1.47242977790668 0.558198831691366 3.97580701695623e-05 0.0129901067617888 7.6999 8.36546 12.9603 11.3687 GeneID:2889,Genbank:XM_005272186.4,HGNC:HGNC:4568,MIM:600303 Rap guanine nucleotide exchange factor 1 hsa04015,hsa04510,hsa04722,hsa04910,hsa05211 Rap1 signaling pathway|Focal adhesion|Neurotrophin signaling pathway|Insulin signaling pathway|Renal cell carcinoma RAPGEF2 419.892487363188 442.343026516173 397.441948210203 0.89849262763425 -0.154421428791704 0.47800335215234 1 1.50236 1.30105 1.49321 1.06796 GeneID:9693,Genbank:XM_005263358.3,HGNC:HGNC:16854,MIM:609530 Rap guanine nucleotide exchange factor 2 GO:0000165,GO:0001568,GO:0001764,GO:0004871,GO:0005088,GO:0005096,GO:0005509,GO:0005737,GO:0005770,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0005923,GO:0007186,GO:0007218,GO:0007264,GO:0008285,GO:0010976,GO:0016020,GO:0016324,GO:0017034,GO:0019933,GO:0019992,GO:0021591,GO:0021884,GO:0030033,GO:0030139,GO:0030165,GO:0030552,GO:0031175,GO:0031547,GO:0031697,GO:0032092,GO:0032486,GO:0035556,GO:0038180,GO:0043005,GO:0043025,GO:0043234,GO:0043547,GO:0043950,GO:0045202,GO:0045860,GO:0048022,GO:0048167,GO:0048471,GO:0050699,GO:0050774,GO:0061028,GO:0070300,GO:0070374,GO:0071320,GO:0071321,GO:0071880,GO:0072659,GO:0090557,GO:1901888,GO:1990090,GO:2000481,GO:2000670,GO:2001214,GO:2001224 MAPK cascade|blood vessel development|neuron migration|signal transducer activity|Ras guanyl-nucleotide exchange factor activity|GTPase activator activity|calcium ion binding|cytoplasm|late endosome|cytosol|plasma membrane|integral component of plasma membrane|cell-cell junction|bicellular tight junction|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|small GTPase mediated signal transduction|negative regulation of cell proliferation|positive regulation of neuron projection development|membrane|apical plasma membrane|Rap guanyl-nucleotide exchange factor activity|cAMP-mediated signaling|diacylglycerol binding|ventricular system development|forebrain neuron development|microvillus assembly|endocytic vesicle|PDZ domain binding|cAMP binding|neuron projection development|brain-derived neurotrophic factor receptor signaling pathway|beta-1 adrenergic receptor binding|positive regulation of protein binding|Rap protein signal transduction|intracellular signal transduction|nerve growth factor signaling pathway|neuron projection|neuronal cell body|protein complex|positive regulation of GTPase activity|positive regulation of cAMP-mediated signaling|synapse|positive regulation of protein kinase activity|negative regulation of melanin biosynthetic process|regulation of synaptic plasticity|perinuclear region of cytoplasm|WW domain binding|negative regulation of dendrite morphogenesis|establishment of endothelial barrier|phosphatidic acid binding|positive regulation of ERK1 and ERK2 cascade|cellular response to cAMP|cellular response to cGMP|adenylate cyclase-activating adrenergic receptor signaling pathway|protein localization to plasma membrane|establishment of endothelial intestinal barrier|regulation of cell junction assembly|cellular response to nerve growth factor stimulus|positive regulation of cAMP-dependent protein kinase activity|positive regulation of dendritic cell apoptotic process|positive regulation of vasculogenesis|positive regulation of neuron migration hsa04010,hsa04015,hsa04530 MAPK signaling pathway|Rap1 signaling pathway|Tight junction RAPGEF3 35.891025491252 34.9577486723887 36.8243023101153 1.0533945608231 0.0750459153033915 0.898858726124997 1 0.13726 0.115379 0.117229 0.185977 GeneID:10411,Genbank:NM_001098531.2,HGNC:HGNC:16629,MIM:606057 Rap guanine nucleotide exchange factor 3 GO:0001525,GO:0005085,GO:0005622,GO:0005886,GO:0005902,GO:0007165,GO:0008283,GO:0012505,GO:0016020,GO:0017034,GO:0019904,GO:0019933,GO:0030027,GO:0030175,GO:0030552,GO:0030822,GO:0032486,GO:0033138,GO:0034242,GO:0043547,GO:0045766,GO:0046827,GO:0050796,GO:0051496,GO:0060143,GO:0061028,GO:0070062,GO:0071320,GO:1901985,GO:2000249 angiogenesis|guanyl-nucleotide exchange factor activity|intracellular|plasma membrane|microvillus|signal transduction|cell proliferation|endomembrane system|membrane|Rap guanyl-nucleotide exchange factor activity|protein domain specific binding|cAMP-mediated signaling|lamellipodium|filopodium|cAMP binding|positive regulation of cAMP catabolic process|Rap protein signal transduction|positive regulation of peptidyl-serine phosphorylation|negative regulation of syncytium formation by plasma membrane fusion|positive regulation of GTPase activity|positive regulation of angiogenesis|positive regulation of protein export from nucleus|regulation of insulin secretion|positive regulation of stress fiber assembly|positive regulation of syncytium formation by plasma membrane fusion|establishment of endothelial barrier|extracellular exosome|cellular response to cAMP|positive regulation of protein acetylation|regulation of actin cytoskeleton reorganization hsa04015,hsa04024,hsa04072,hsa04261,hsa04670,hsa04720,hsa04726 Rap1 signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Leukocyte transendothelial migration|Long-term potentiation|Serotonergic synapse RAPGEF4 152.753629221682 155.25353086855 150.253727574814 0.967795880288425 -0.0472252969209555 0.873664463920948 1 0.836463 0.836217 0.941098 0.610468 GeneID:11069,Genbank:XM_006712205.3,HGNC:HGNC:16626,MIM:606058 Rap guanine nucleotide exchange factor 4 GO:0005085,GO:0005088,GO:0005829,GO:0005886,GO:0007186,GO:0007264,GO:0016020,GO:0017016,GO:0017156,GO:0017157,GO:0019933,GO:0030073,GO:0030552,GO:0050796 guanyl-nucleotide exchange factor activity|Ras guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|membrane|Ras GTPase binding|calcium ion regulated exocytosis|regulation of exocytosis|cAMP-mediated signaling|insulin secretion|cAMP binding|regulation of insulin secretion hsa04015,hsa04024,hsa04072,hsa04261,hsa04670,hsa04911 Rap1 signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Adrenergic signaling in cardiomyocytes|Leukocyte transendothelial migration|Insulin secretion RAPGEF5 54.3786857266884 63.6886479433864 45.0687235099903 0.707641392388365 -0.498909656176578 0.216283546310503 1 0.286794 0.176036 0.173479 0.153614 GeneID:9771,Genbank:NM_012294.3,HGNC:HGNC:16862,MIM:609527 Rap guanine nucleotide exchange factor 5 GO:0005634,GO:0005654,GO:0007264,GO:0016604,GO:0017034,GO:0030742 nucleus|nucleoplasm|small GTPase mediated signal transduction|nuclear body|Rap guanyl-nucleotide exchange factor activity|GTP-dependent protein binding hsa04014,hsa04015 Ras signaling pathway|Rap1 signaling pathway RAPGEF6 171.854085400395 171.146521139286 172.561649661504 1.00826852052146 0.0118799063329978 0.960919430676485 1 0.654705 0.515896 0.733619 0.423391 GeneID:51735,Genbank:NM_016340.5,HGNC:HGNC:20655,MIM:610499 Rap guanine nucleotide exchange factor 6 GO:0005085,GO:0005813,GO:0005829,GO:0005886,GO:0007265,GO:0016324,GO:0017016,GO:0030033,GO:0030139,GO:0030742,GO:0043087,GO:0043547,GO:0070300,GO:0072659 guanyl-nucleotide exchange factor activity|centrosome|cytosol|plasma membrane|Ras protein signal transduction|apical plasma membrane|Ras GTPase binding|microvillus assembly|endocytic vesicle|GTP-dependent protein binding|regulation of GTPase activity|positive regulation of GTPase activity|phosphatidic acid binding|protein localization to plasma membrane hsa04015,hsa04530 Rap1 signaling pathway|Tight junction RAPGEFL1 93.8833708242553 93.265419849352 94.5013217991584 1.01325144894863 0.0189922384387984 0.952407539615508 1 0.613256 0.480303 0.534415 0.595968 GeneID:51195,Genbank:NM_001303534.2,HGNC:HGNC:17428 Rap guanine nucleotide exchange factor like 1 GO:0005085,GO:0005622,GO:0007186,GO:0007264,GO:0007399,GO:0016020 guanyl-nucleotide exchange factor activity|intracellular|G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|nervous system development|membrane RAPH1 734.55921574842 747.863130339437 721.255301157404 0.964421525674148 -0.0522642429548332 0.865146594783804 1 2.3094 2.11359 2.67586 1.69749 GeneID:65059,Genbank:NM_213589.2,HGNC:HGNC:14436,MIM:609035 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 GO:0005829,GO:0005856,GO:0005886,GO:0007165,GO:0016604,GO:0030027,GO:0030175,GO:0048675 cytosol|cytoskeleton|plasma membrane|signal transduction|nuclear body|lamellipodium|filopodium|axon extension RAPSN 2.45261780554172 1.02816907859967 3.87706653248377 3.77084529498224 1.91488796279984 0.422271787049021 1 0 0.027834 0.0300517 0.0279962 GeneID:5913,Genbank:NM_032645.4,HGNC:HGNC:9863,MIM:601592 receptor associated protein of the synapse GO:0005794,GO:0005813,GO:0005829,GO:0005886,GO:0007268,GO:0007271,GO:0030054,GO:0031594,GO:0033130,GO:0035255,GO:0043495,GO:0043525,GO:0046872,GO:0071340,GO:0099634,GO:1900075,GO:1901626 Golgi apparatus|centrosome|cytosol|plasma membrane|chemical synaptic transmission|synaptic transmission, cholinergic|cell junction|neuromuscular junction|acetylcholine receptor binding|ionotropic glutamate receptor binding|protein membrane anchor|positive regulation of neuron apoptotic process|metal ion binding|skeletal muscle acetylcholine-gated channel clustering|postsynaptic specialization membrane|positive regulation of neuromuscular synaptic transmission|regulation of postsynaptic membrane organization RARA 464.691321199137 461.744985841475 467.637656556799 1.01276174272815 0.0182948128223849 0.944975383666926 1 2.60978 2.82644 2.72042 3.13894 GeneID:5914,Genbank:NM_000964.3,HGNC:HGNC:9864,MIM:180240 retinoic acid receptor alpha hsa04659,hsa04915,hsa05200,hsa05202,hsa05221 Th17 cell differentiation|Estrogen signaling pathway|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia RARB 1327.6672674444 1434.91039756233 1220.42413732648 0.85052288937328 -0.23357803249551 0.190255838707512 1 12.5079 11.601 11.6515 8.90311 GeneID:5915,Genbank:NM_001290216.2,HGNC:HGNC:9865,MIM:180220 retinoic acid receptor beta GO:0000122,GO:0000977,GO:0001657,GO:0002068,GO:0003148,GO:0003406,GO:0003417,GO:0003677,GO:0003707,GO:0003708,GO:0005634,GO:0005654,GO:0005737,GO:0006367,GO:0007165,GO:0008144,GO:0008270,GO:0008284,GO:0008285,GO:0021756,GO:0031641,GO:0032331,GO:0032403,GO:0035116,GO:0035264,GO:0043065,GO:0043066,GO:0045666,GO:0045944,GO:0046965,GO:0048048,GO:0048566,GO:0055012 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|ureteric bud development|glandular epithelial cell development|outflow tract septum morphogenesis|retinal pigment epithelium development|growth plate cartilage development|DNA binding|steroid hormone receptor activity|retinoic acid receptor activity|nucleus|nucleoplasm|cytoplasm|transcription initiation from RNA polymerase II promoter|signal transduction|drug binding|zinc ion binding|positive regulation of cell proliferation|negative regulation of cell proliferation|striatum development|regulation of myelination|negative regulation of chondrocyte differentiation|protein complex binding|embryonic hindlimb morphogenesis|multicellular organism growth|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|retinoid X receptor binding|embryonic eye morphogenesis|embryonic digestive tract development|ventricular cardiac muscle cell differentiation hsa05200,hsa05222,hsa05223,hsa05226 Pathways in cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer RARG 194.945744894079 185.368400451158 204.523089337 1.10333308610973 0.141868393047008 0.539802744671376 1 2.05654 1.68021 2.31615 2.03104 GeneID:5916,Genbank:NM_001243731.1,HGNC:HGNC:9866,MIM:180190 retinoic acid receptor gamma RARRES2 17.7073292146625 18.4590171401091 16.955641289216 0.918556018476932 -0.122560387579618 0.898372346393809 1 0.418143 0.301901 0.258824 0.36085 GeneID:5919,Genbank:NM_002889.3,HGNC:HGNC:9868,MIM:601973 retinoic acid receptor responder 2 GO:0001523,GO:0001701,GO:0001934,GO:0002576,GO:0005102,GO:0005576,GO:0005615,GO:0006935,GO:0006954,GO:0010759,GO:0019732,GO:0030154,GO:0031012,GO:0031089,GO:0045087,GO:0045600,GO:0048566,GO:0050829,GO:0050830,GO:0050921,GO:0050994,GO:0061760,GO:0070062,GO:2001275 retinoid metabolic process|in utero embryonic development|positive regulation of protein phosphorylation|platelet degranulation|receptor binding|extracellular region|extracellular space|chemotaxis|inflammatory response|positive regulation of macrophage chemotaxis|antifungal humoral response|cell differentiation|extracellular matrix|platelet dense granule lumen|innate immune response|positive regulation of fat cell differentiation|embryonic digestive tract development|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|positive regulation of chemotaxis|regulation of lipid catabolic process|antifungal innate immune response|extracellular exosome|positive regulation of glucose import in response to insulin stimulus RARRES3 46.1115890682668 38.4362747607751 53.7869033757585 1.39937867835852 0.484786415301273 0.255152618839401 1 2.15103 2.49485 2.99598 3.74316 GeneID:5920,Genbank:NM_004585.4,HGNC:HGNC:9869,MIM:605092 retinoic acid receptor responder 3 RARS 1865.55848764711 1884.61532076383 1846.50165453039 0.979776421313399 -0.0294755218454315 0.847655704884117 1 31.2926 31.4811 33.2952 29.0058 GeneID:5917,Genbank:NM_002887.3,HGNC:HGNC:9870,MIM:107820 arginyl-tRNA synthetase GO:0000049,GO:0004814,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006418,GO:0006420,GO:0016020,GO:0017101,GO:0034618,GO:0045296,GO:0070062 tRNA binding|arginine-tRNA ligase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|tRNA aminoacylation for protein translation|arginyl-tRNA aminoacylation|membrane|aminoacyl-tRNA synthetase multienzyme complex|arginine binding|cadherin binding|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis RARS2 943.094052474359 955.727806006803 930.460298941916 0.973562025813124 -0.0386551986511816 0.793891502789374 1 5.44408 5.57543 5.07336 5.59832 GeneID:57038,Genbank:NM_001350505.1,HGNC:HGNC:21406,MIM:611524 arginyl-tRNA synthetase 2, mitochondrial GO:0003723,GO:0004814,GO:0005524,GO:0005739,GO:0005759,GO:0006418,GO:0006420,GO:0032543 RNA binding|arginine-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|arginyl-tRNA aminoacylation|mitochondrial translation hsa00970 Aminoacyl-tRNA biosynthesis RASA1 390.055230015241 398.621827538345 381.488632492137 0.957018924046351 -0.0633806421113887 0.877929615691861 1 2.1443 1.95799 2.50542 1.46834 GeneID:5921,Genbank:XM_011543527.3,HGNC:HGNC:9871,MIM:139150 RAS p21 protein activator 1 GO:0000165,GO:0000281,GO:0001570,GO:0001726,GO:0001784,GO:0001953,GO:0003924,GO:0005096,GO:0005102,GO:0005737,GO:0005829,GO:0007162,GO:0007165,GO:0008360,GO:0009790,GO:0019870,GO:0030833,GO:0031235,GO:0035556,GO:0043066,GO:0043524,GO:0046580,GO:0048013,GO:0048514,GO:0051020,GO:0051252 MAPK cascade|mitotic cytokinesis|vasculogenesis|ruffle|phosphotyrosine residue binding|negative regulation of cell-matrix adhesion|GTPase activity|GTPase activator activity|receptor binding|cytoplasm|cytosol|negative regulation of cell adhesion|signal transduction|regulation of cell shape|embryo development|potassium channel inhibitor activity|regulation of actin filament polymerization|intrinsic component of the cytoplasmic side of the plasma membrane|intracellular signal transduction|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|negative regulation of Ras protein signal transduction|ephrin receptor signaling pathway|blood vessel morphogenesis|GTPase binding|regulation of RNA metabolic process hsa04010,hsa04014,hsa04360 MAPK signaling pathway|Ras signaling pathway|Axon guidance RASA2 82.104093454297 101.192806174932 63.0153807336622 0.622725894415139 -0.68333082375378 0.0637431954353303 0.897898872552551 0.492427 0.45116 0.343185 0.222397 GeneID:5922,Genbank:NM_001303245.1,HGNC:HGNC:9872,MIM:601589 RAS p21 protein activator 2 GO:0000165,GO:0005096,GO:0005737,GO:0005829,GO:0007165,GO:0031235,GO:0046580,GO:0046872,GO:0048471 MAPK cascade|GTPase activator activity|cytoplasm|cytosol|signal transduction|intrinsic component of the cytoplasmic side of the plasma membrane|negative regulation of Ras protein signal transduction|metal ion binding|perinuclear region of cytoplasm hsa04010,hsa04014,hsa05203 MAPK signaling pathway|Ras signaling pathway|Viral carcinogenesis RASA3 933.688363704203 865.633137287512 1001.74359012089 1.15723803418604 0.210685645274255 0.176961531325117 1 4.94881 5.27984 6.30256 5.87393 GeneID:22821,Genbank:NM_007368.3,HGNC:HGNC:20331,MIM:605182 RAS p21 protein activator 3 GO:0000165,GO:0005096,GO:0005737,GO:0005829,GO:0007165,GO:0015278,GO:0031235,GO:0046580,GO:0046872 MAPK cascade|GTPase activator activity|cytoplasm|cytosol|signal transduction|calcium-release channel activity|intrinsic component of the cytoplasmic side of the plasma membrane|negative regulation of Ras protein signal transduction|metal ion binding hsa04014 Ras signaling pathway RASA4 28.2931265668235 27.5204337487663 29.0658193848807 1.05615411625493 0.0788203711864814 0.951516654234845 1 0.150651 0.153356 0.0959695 0.275965 GeneID:10156,Genbank:NM_001079877.2,HGNC:HGNC:23181,MIM:607943 RAS p21 protein activator 4 GO:0000165,GO:0005096,GO:0005829,GO:0031235,GO:0034260,GO:0046580,GO:0046872,GO:0071277 MAPK cascade|GTPase activator activity|cytosol|intrinsic component of the cytoplasmic side of the plasma membrane|negative regulation of GTPase activity|negative regulation of Ras protein signal transduction|metal ion binding|cellular response to calcium ion hsa04014 Ras signaling pathway RASA4B 4.55828719550609 5.23689794236822 3.87967644864396 0.740834839887964 -0.432776147812319 0.850256406852857 1 0.138715 0.0395339 0.15605 0.013246 GeneID:100271927,Genbank:NM_001277335.1,HGNC:HGNC:35202 RAS p21 protein activator 4B GO:0005096,GO:0005737,GO:0005829,GO:0031235,GO:0035556,GO:0046580,GO:0046872 GTPase activator activity|cytoplasm|cytosol|intrinsic component of the cytoplasmic side of the plasma membrane|intracellular signal transduction|negative regulation of Ras protein signal transduction|metal ion binding hsa04014 Ras signaling pathway RASAL2 724.996744720663 729.250225720165 720.743263721161 0.988334646052933 -0.0169284797413112 0.961285786999345 1 1.70954 1.54851 1.93811 1.33735 GeneID:9462,Genbank:NM_170692.2,HGNC:HGNC:9874,MIM:606136 RAS protein activator like 2 GO:0000165,GO:0005096,GO:0005737,GO:0005829,GO:0007165,GO:0031235,GO:0046580 MAPK cascade|GTPase activator activity|cytoplasm|cytosol|signal transduction|intrinsic component of the cytoplasmic side of the plasma membrane|negative regulation of Ras protein signal transduction hsa04014 Ras signaling pathway RASAL3 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0116167 0.012385 0 GeneID:64926,Genbank:NM_022904.2,HGNC:HGNC:26129,MIM:616561 RAS protein activator like 3 GO:0000165,GO:0005096,GO:0005737,GO:0005829,GO:0005938,GO:0016020,GO:0031235,GO:0046580,GO:0051142,GO:0070062,GO:0098562 MAPK cascade|GTPase activator activity|cytoplasm|cytosol|cell cortex|membrane|intrinsic component of the cytoplasmic side of the plasma membrane|negative regulation of Ras protein signal transduction|positive regulation of NK T cell proliferation|extracellular exosome|cytoplasmic side of membrane hsa04014 Ras signaling pathway RASD1 5.4736544825185 4.16070258908361 6.7866063759534 1.63112028092547 0.705863172176358 0.617747653258465 1 0.16107 0.0824049 0.266506 0.138479 GeneID:51655,Genbank:NM_001199989.1,HGNC:HGNC:15828,MIM:605550 ras related dexamethasone induced 1 GO:0003924,GO:0005525,GO:0005634,GO:0005886,GO:0007165,GO:0007186,GO:0007263,GO:0016529,GO:0045892,GO:0048471 GTPase activity|GTP binding|nucleus|plasma membrane|signal transduction|G-protein coupled receptor signaling pathway|nitric oxide mediated signal transduction|sarcoplasmic reticulum|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm hsa04713,hsa04934 Circadian entrainment|Cushing syndrome RASD2 9.45201741767254 9.69556683466942 9.20846800067565 0.949760664610965 -0.0743640882655877 0.994093178235074 1 0.0447243 0.0571482 0.0599988 0.0448459 GeneID:23551,Genbank:XM_005261442.5,HGNC:HGNC:18229,MIM:612842 RASD family member 2 GO:0001963,GO:0003924,GO:0005525,GO:0005886,GO:0007165,GO:0007626,GO:0031397,GO:0031624,GO:0031681,GO:0033235,GO:0043548,GO:0043949,GO:0051897 synaptic transmission, dopaminergic|GTPase activity|GTP binding|plasma membrane|signal transduction|locomotory behavior|negative regulation of protein ubiquitination|ubiquitin conjugating enzyme binding|G-protein beta-subunit binding|positive regulation of protein sumoylation|phosphatidylinositol 3-kinase binding|regulation of cAMP-mediated signaling|positive regulation of protein kinase B signaling RASEF 14.4935246051839 15.422536178995 13.5645130313728 0.879525447302711 -0.185202775102217 0.852664052065174 1 0.0803008 0.0890857 0.045014 0.113641 GeneID:158158,Genbank:NM_152573.3,HGNC:HGNC:26464,MIM:611344 RAS and EF-hand domain containing GO:0003924,GO:0005509,GO:0005525,GO:0005829,GO:0019003,GO:0042802,GO:0048471,GO:0051260 GTPase activity|calcium ion binding|GTP binding|cytosol|GDP binding|identical protein binding|perinuclear region of cytoplasm|protein homooligomerization RASGEF1A 1.48378615844747 1.02816907859967 1.93940323829528 1.88626878464064 0.915535268080234 0.868235938463046 1 0.0119275 0.0106867 0.0336318 0.0104557 GeneID:221002,Genbank:NM_145313.3,HGNC:HGNC:24246,MIM:614531 RasGEF domain family member 1A GO:0000165,GO:0005088,GO:0005829,GO:0007264,GO:0016477,GO:0046579 MAPK cascade|Ras guanyl-nucleotide exchange factor activity|cytosol|small GTPase mediated signal transduction|cell migration|positive regulation of Ras protein signal transduction RASGEF1C 1.53344401076412 1.61429302992691 1.45259499160132 0.899833527539349 -0.152269972565186 1 1 0.0576539 0 0 0.0332422 GeneID:255426,Genbank:NM_175062.3,HGNC:HGNC:27400 RasGEF domain family member 1C GO:0005085,GO:0005622,GO:0007264 guanyl-nucleotide exchange factor activity|intracellular|small GTPase mediated signal transduction RASGRF1 43.1528128271091 60.133686615846 26.1719390383723 0.43522924522435 -1.20015259316454 0.00574617946864135 0.302732928847894 0.122965 0.167455 0.0594905 0.0590836 GeneID:5923,Genbank:NM_001145648.1,HGNC:HGNC:9875,MIM:606600 Ras protein specific guanine nucleotide releasing factor 1 hsa04010,hsa04014,hsa04510 MAPK signaling pathway|Ras signaling pathway|Focal adhesion RASGRF2 1.21386734807293 0.490071401957362 1.93766329418849 3.95383873951713 1.98325403079315 0.683591311517638 1 1.91909e-07 2.12439e-08 0.00550848 0.00511301 GeneID:5924,Genbank:XM_005248565.1,HGNC:HGNC:9876,MIM:606614 Ras protein specific guanine nucleotide releasing factor 2 GO:0000165,GO:0005085,GO:0005088,GO:0005089,GO:0005516,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0007186,GO:0007264,GO:0034976,GO:0035023,GO:0043065,GO:0051056 MAPK cascade|guanyl-nucleotide exchange factor activity|Ras guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|calmodulin binding|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|response to endoplasmic reticulum stress|regulation of Rho protein signal transduction|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction hsa04010,hsa04014 MAPK signaling pathway|Ras signaling pathway RASGRP1 18.5205655339998 20.073310170036 16.9678208979636 0.845292617621779 -0.242477244719167 0.751975204820718 1 0.139955 0.11656 0.149934 0.0808453 GeneID:10125,Genbank:NM_001306086.1,HGNC:HGNC:9878,MIM:603962 RAS guanyl releasing protein 1 GO:0000139,GO:0000165,GO:0001786,GO:0001816,GO:0001934,GO:0002437,GO:0005085,GO:0005088,GO:0005096,GO:0005509,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0007165,GO:0007265,GO:0008270,GO:0008289,GO:0014066,GO:0016020,GO:0019992,GO:0030154,GO:0031210,GO:0032252,GO:0032725,GO:0032760,GO:0032825,GO:0033089,GO:0042629,GO:0042803,GO:0043303,GO:0043406,GO:0043547,GO:0045954,GO:0046330,GO:0046579,GO:0047496,GO:0051259,GO:0070372,GO:0070374,GO:0090630,GO:1902715 Golgi membrane|MAPK cascade|phosphatidylserine binding|cytokine production|positive regulation of protein phosphorylation|inflammatory response to antigenic stimulus|guanyl-nucleotide exchange factor activity|Ras guanyl-nucleotide exchange factor activity|GTPase activator activity|calcium ion binding|endoplasmic reticulum membrane|Golgi apparatus|cytosol|plasma membrane|signal transduction|Ras protein signal transduction|zinc ion binding|lipid binding|regulation of phosphatidylinositol 3-kinase signaling|membrane|diacylglycerol binding|cell differentiation|phosphatidylcholine binding|secretory granule localization|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of tumor necrosis factor production|positive regulation of natural killer cell differentiation|positive regulation of T cell differentiation in thymus|mast cell granule|protein homodimerization activity|mast cell degranulation|positive regulation of MAP kinase activity|positive regulation of GTPase activity|positive regulation of natural killer cell mediated cytotoxicity|positive regulation of JNK cascade|positive regulation of Ras protein signal transduction|vesicle transport along microtubule|protein oligomerization|regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|activation of GTPase activity|positive regulation of interferon-gamma secretion hsa04010,hsa04014,hsa04611,hsa04660,hsa05200 MAPK signaling pathway|Ras signaling pathway|Platelet activation|T cell receptor signaling pathway|Pathways in cancer RASGRP2 0.974269732491135 0.980142803914724 0.968396661067546 0.988015886256305 -0.0173938558720137 1 1 0 0.0215189 0 0 GeneID:10235,Genbank:XM_011544722.2,HGNC:HGNC:9879,MIM:605577 RAS guanyl releasing protein 2 hsa04010,hsa04014,hsa04015,hsa04062,hsa04611,hsa05200 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Platelet activation|Pathways in cancer RASGRP3 46.9596417363137 50.7743037039711 43.1449797686562 0.849740451788446 -0.234905849046983 0.612993971470131 1 0.211666 0.233208 0.277345 0.1022 GeneID:25780,Genbank:NM_001349975.1,HGNC:HGNC:14545,MIM:609531 RAS guanyl releasing protein 3 GO:0000165,GO:0004871,GO:0005085,GO:0005088,GO:0005096,GO:0005509,GO:0005886,GO:0005887,GO:0007264,GO:0007265,GO:0019900,GO:0019992,GO:0032045,GO:0048471 MAPK cascade|signal transducer activity|guanyl-nucleotide exchange factor activity|Ras guanyl-nucleotide exchange factor activity|GTPase activator activity|calcium ion binding|plasma membrane|integral component of plasma membrane|small GTPase mediated signal transduction|Ras protein signal transduction|kinase binding|diacylglycerol binding|guanyl-nucleotide exchange factor complex|perinuclear region of cytoplasm hsa04010,hsa04014,hsa04015,hsa04662,hsa05200 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|B cell receptor signaling pathway|Pathways in cancer RASGRP4 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:115727,Genbank:NM_001146202.1,HGNC:HGNC:18958,MIM:607320 RAS guanyl releasing protein 4 GO:0000165,GO:0005088,GO:0005509,GO:0005829,GO:0005886,GO:0007169,GO:0007202,GO:0007264,GO:0008277,GO:0008283,GO:0009991,GO:0016020,GO:0019992,GO:0030099,GO:0030742,GO:0046579,GO:1904628 MAPK cascade|Ras guanyl-nucleotide exchange factor activity|calcium ion binding|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|activation of phospholipase C activity|small GTPase mediated signal transduction|regulation of G-protein coupled receptor protein signaling pathway|cell proliferation|response to extracellular stimulus|membrane|diacylglycerol binding|myeloid cell differentiation|GTP-dependent protein binding|positive regulation of Ras protein signal transduction|cellular response to phorbol 13-acetate 12-myristate hsa04010,hsa04014,hsa05200 MAPK signaling pathway|Ras signaling pathway|Pathways in cancer RASIP1 15.9679803048479 18.8530359926965 13.0829246169992 0.693942589515419 -0.527111782584448 0.469663590180965 1 0.17166 0.223898 0.156515 0.24436 GeneID:54922,Genbank:XM_017026915.1,HGNC:HGNC:24716,MIM:609623 Ras interacting protein 1 GO:0001525,GO:0001570,GO:0005795,GO:0007165,GO:0010507,GO:0043087,GO:0048471,GO:0048754 angiogenesis|vasculogenesis|Golgi stack|signal transduction|negative regulation of autophagy|regulation of GTPase activity|perinuclear region of cytoplasm|branching morphogenesis of an epithelial tube RASL10A 2.3178823464652 3.18055978516888 1.45520490776151 0.457531065615307 -1.12805839151785 0.695575632266019 1 0.0195063 0 0.0179928 0 GeneID:10633,Genbank:XM_011529823.1,HGNC:HGNC:16954,MIM:602220 RAS like family 10 member A GO:0003924,GO:0005525,GO:0005730,GO:0005886,GO:0007264 GTPase activity|GTP binding|nucleolus|plasma membrane|small GTPase mediated signal transduction RASL10B 33.4181151905115 38.2441696620354 28.5920607189877 0.747618812793073 -0.419625221922826 0.392493207265149 1 0.274861 0.354297 0.256041 0.265401 GeneID:91608,Genbank:NM_033315.3,HGNC:HGNC:30295,MIM:612128 RAS like family 10 member B GO:0003050,GO:0003924,GO:0005525,GO:0005886,GO:0007165,GO:0090277 regulation of systemic arterial blood pressure by atrial natriuretic peptide|GTPase activity|GTP binding|plasma membrane|signal transduction|positive regulation of peptide hormone secretion RASL11A 11.7065615927706 14.6923334036129 8.72078978192829 0.593560569472498 -0.752532838703469 0.374300006313977 1 0.331903 0.548503 0.170993 0.319102 GeneID:387496,Genbank:NM_206827.1,HGNC:HGNC:23802,MIM:612403 RAS like family 11 member A GO:0003924,GO:0005525,GO:0005730,GO:0006351,GO:0007165,GO:0016020,GO:0045943 GTPase activity|GTP binding|nucleolus|transcription, DNA-templated|signal transduction|membrane|positive regulation of transcription from RNA polymerase I promoter RASL11B 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0255168 0 GeneID:65997,Genbank:NM_023940.2,HGNC:HGNC:23804,MIM:612404 RAS like family 11 member B RASSF1 992.577411822269 972.813678491265 1012.34114515327 1.04063210410786 0.0574601210979644 0.738018875145782 1 12.9886 13.9778 13.4624 14.6904 GeneID:11186,Genbank:NM_001206957.1,HGNC:HGNC:9882,MIM:605082 Ras association domain family member 1 hsa04014,hsa04390,hsa04392,hsa05200,hsa05206,hsa05219,hsa05223 Ras signaling pathway|Hippo signaling pathway|Hippo signaling pathway - multiple species|Pathways in cancer|MicroRNAs in cancer|Bladder cancer|Non-small cell lung cancer RASSF2 790.870202766216 773.884940917862 807.85546461457 1.04389609087937 0.0619781135996142 0.691470221040936 1 4.48767 4.2648 4.49555 4.61203 GeneID:9770,Genbank:XM_017028153.1,HGNC:HGNC:9883,MIM:609492 Ras association domain family member 2 hsa04392 Hippo signaling pathway - multiple species RASSF3 601.676047272129 630.498984900767 572.853109643492 0.908571026063828 -0.138328795678624 0.406599158022041 1 7.25324 7.74032 7.36654 6.39204 GeneID:283349,Genbank:NM_178169.3,HGNC:HGNC:14271,MIM:607019 Ras association domain family member 3 GO:0005829,GO:0005874,GO:0005886,GO:0007165,GO:0042802,GO:0042981 cytosol|microtubule|plasma membrane|signal transduction|identical protein binding|regulation of apoptotic process RASSF4 398.543208857948 390.992407515983 406.094010199913 1.03862377476809 0.0546731551363093 0.754812389265658 1 3.06902 2.74652 2.85546 3.11121 GeneID:83937,Genbank:XM_011540255.2,HGNC:HGNC:20793,MIM:610559 Ras association domain family member 4 GO:0007049,GO:0007165 cell cycle|signal transduction hsa04392 Hippo signaling pathway - multiple species RASSF5 72.4141211134596 92.9772622012424 51.8509800256768 0.557673766661887 -0.842506687629368 0.0142829339941879 0.494072291254673 1.07779 0.959311 0.540251 0.621684 GeneID:83593,Genbank:NM_182663.3,HGNC:HGNC:17609,MIM:607020 Ras association domain family member 5 hsa04014,hsa04015,hsa04218,hsa04670,hsa05200,hsa05223 Ras signaling pathway|Rap1 signaling pathway|Cellular senescence|Leukocyte transendothelial migration|Pathways in cancer|Non-small cell lung cancer RASSF7 389.858298392444 401.726969085215 377.989627699673 0.940911755465173 -0.0878686704697374 0.61543322391364 1 11.1805 12.4736 10.9463 12.1893 GeneID:8045,Genbank:NM_001143993.1,HGNC:HGNC:1166,MIM:143023 Ras association domain family member 7 GO:0005737,GO:0005815,GO:0006915,GO:0007165,GO:0070507 cytoplasm|microtubule organizing center|apoptotic process|signal transduction|regulation of microtubule cytoskeleton organization RASSF8 271.797173085138 281.342908993082 262.251437177193 0.93214162786538 -0.10137892295222 0.852450385830433 1 1.65468 1.23441 1.75899 0.904539 GeneID:11228,Genbank:XM_024448819.1,HGNC:HGNC:13232,MIM:608231 Ras association domain family member 8 GO:0007165,GO:0034334 signal transduction|adherens junction maintenance RASSF9 13.06004801803 14.0003482478079 12.1197477882521 0.865674737065898 -0.20810303687348 0.854337294899203 1 0.135088 0.0909298 0.122304 0.0532751 GeneID:9182,Genbank:XM_011538988.2,HGNC:HGNC:15739,MIM:610383 Ras association domain family member 9 GO:0005215,GO:0005768,GO:0005829,GO:0006605,GO:0007165,GO:0012510,GO:0016197,GO:0070062 transporter activity|endosome|cytosol|protein targeting|signal transduction|trans-Golgi network transport vesicle membrane|endosomal transport|extracellular exosome RAVER1 2909.76818660784 2990.7382292426 2828.79814397307 0.945852805275257 -0.0803124077520841 0.537769717799563 1 39.4775 40.9998 39.7361 37.564 GeneID:125950,Genbank:NM_133452.2,HGNC:HGNC:30296,MIM:609950 ribonucleoprotein, PTB binding 1 GO:0000398,GO:0003676,GO:0003723,GO:0005634,GO:0005737 mRNA splicing, via spliceosome|nucleic acid binding|RNA binding|nucleus|cytoplasm RAVER2 321.110374247941 317.972785625191 324.247962870691 1.01973495069134 0.028194215908875 0.883478111108127 1 3.11775 2.62441 3.27975 2.52205 GeneID:55225,Genbank:XM_011541706.2,HGNC:HGNC:25577,MIM:609953 ribonucleoprotein, PTB binding 2 GO:0000398,GO:0003676,GO:0003723,GO:0005634,GO:0005737 mRNA splicing, via spliceosome|nucleic acid binding|RNA binding|nucleus|cytoplasm RB1 937.13486368044 955.224874947173 919.044852413707 0.962124078337609 -0.0557051347182327 0.907233022938828 1 8.13029 6.56899 8.86109 5.40879 GeneID:5925,Genbank:NM_000321.2,HGNC:HGNC:9884,MIM:614041 RB transcriptional corepressor 1 hsa01522,hsa04110,hsa04218,hsa04934,hsa05161,hsa05163,hsa05165,hsa05166,hsa05167,hsa05169,hsa05200,hsa05203,hsa05212,hsa05214,hsa05215,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226 Endocrine resistance|Cell cycle|Cellular senescence|Cushing syndrome|Hepatitis B|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Pancreatic cancer|Glioma|Prostate cancer|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer RB1CC1 220.118589893389 225.03475804438 215.202421742398 0.95630747717629 -0.0644535389448219 0.775155853135339 1 0.6386 0.67732 0.718431 0.560226 GeneID:9821,Genbank:NM_001083617.1,HGNC:HGNC:15574,MIM:606837 RB1 inducible coiled-coil 1 GO:0000045,GO:0000422,GO:0001889,GO:0001934,GO:0005789,GO:0005829,GO:0006351,GO:0006355,GO:0006914,GO:0007049,GO:0007507,GO:0016236,GO:0016241,GO:0019901,GO:0030242,GO:0031965,GO:0032947,GO:0034045,GO:0045793,GO:0046330,GO:0061709,GO:0061723,GO:1990316,GO:2001237 autophagosome assembly|autophagy of mitochondrion|liver development|positive regulation of protein phosphorylation|endoplasmic reticulum membrane|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|autophagy|cell cycle|heart development|macroautophagy|regulation of macroautophagy|protein kinase binding|autophagy of peroxisome|nuclear membrane|protein complex scaffold activity|phagophore assembly site membrane|positive regulation of cell size|positive regulation of JNK cascade|reticulophagy|glycophagy|Atg1/ULK1 kinase complex|negative regulation of extrinsic apoptotic signaling pathway hsa04140,hsa04211 Autophagy - animal|Longevity regulating pathway RBAK 87.0729536175885 85.4340860731422 88.7118211620347 1.03836565988529 0.0543145774207932 0.91208041259511 1 0.505078 0.459802 0.699475 0.363453 GeneID:57786,Genbank:NM_001204456.1,HGNC:HGNC:17680,MIM:608191 RB associated KRAB zinc finger GO:0003676,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0008270,GO:0045892 nucleic acid binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|negative regulation of transcription, DNA-templated RBAK-RBAKDN 1.74946347503013 1.07619535328461 2.42273159677566 2.25120057374467 1.17069460137475 0.729443551161772 1 0.319199 9.89436e-09 0.148995 0.189728 GeneID:100533952,Genbank:NM_001204513.2,HGNC:HGNC:42971 RBAK-RBAKDN readthrough RBBP4 5041.40215140676 4955.46820089292 5127.33610192061 1.03468247480565 0.0491880988298198 0.696506597570779 1 23.0865 22.2817 23.9627 23.3312 GeneID:5928,Genbank:NM_005610.2,HGNC:HGNC:9887,MIM:602923 RB binding protein 4, chromatin remodeling factor GO:0000790,GO:0004407,GO:0005634,GO:0005654,GO:0005829,GO:0006260,GO:0006335,GO:0006336,GO:0006338,GO:0006351,GO:0006355,GO:0007049,GO:0008285,GO:0016580,GO:0016581,GO:0016589,GO:0031497,GO:0033186,GO:0034080,GO:0035098,GO:0042393,GO:0042826,GO:0043044,GO:0043234,GO:0045814,GO:0051726,GO:0060416,GO:0070317,GO:1901796 nuclear chromatin|histone deacetylase activity|nucleus|nucleoplasm|cytosol|DNA replication|DNA replication-dependent nucleosome assembly|DNA replication-independent nucleosome assembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|negative regulation of cell proliferation|Sin3 complex|NuRD complex|NURF complex|chromatin assembly|CAF-1 complex|CENP-A containing nucleosome assembly|ESC/E(Z) complex|histone binding|histone deacetylase binding|ATP-dependent chromatin remodeling|protein complex|negative regulation of gene expression, epigenetic|regulation of cell cycle|response to growth hormone|negative regulation of G0 to G1 transition|regulation of signal transduction by p53 class mediator hsa04218 Cellular senescence RBBP5 916.546023020878 911.803676274272 921.288369767483 1.01040212245246 0.0149295747690078 0.916154909035124 1 7.89062 7.78694 8.30157 7.69081 GeneID:5929,Genbank:NM_001193273.1,HGNC:HGNC:9888,MIM:600697 RB binding protein 5, histone lysine methyltransferase complex subunit GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0006355,GO:0006974,GO:0018024,GO:0035064,GO:0035097,GO:0043627,GO:0043687,GO:0044212,GO:0044666,GO:0045652,GO:0048188,GO:0051568,GO:0071339,GO:1904837 nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|histone-lysine N-methyltransferase activity|methylated histone binding|histone methyltransferase complex|response to estrogen|post-translational protein modification|transcription regulatory region DNA binding|MLL3/4 complex|regulation of megakaryocyte differentiation|Set1C/COMPASS complex|histone H3-K4 methylation|MLL1 complex|beta-catenin-TCF complex assembly hsa04934 Cushing syndrome RBBP6 309.823086238412 311.371534681428 308.274637795397 0.990054014124316 -0.0144208588026322 0.986459809336163 1 1.24723 1.11959 1.44266 0.953655 GeneID:5930,Genbank:NM_006910.4,HGNC:HGNC:9889,MIM:600938 RB binding protein 6, ubiquitin ligase GO:0000209,GO:0001701,GO:0003723,GO:0004842,GO:0005694,GO:0005730,GO:0005815,GO:0005829,GO:0006260,GO:0006275,GO:0006397,GO:0006974,GO:0008270,GO:0016607,GO:0019901,GO:0035264,GO:0042787,GO:0043234,GO:0048568,GO:0061053,GO:0061630 protein polyubiquitination|in utero embryonic development|RNA binding|ubiquitin-protein transferase activity|chromosome|nucleolus|microtubule organizing center|cytosol|DNA replication|regulation of DNA replication|mRNA processing|cellular response to DNA damage stimulus|zinc ion binding|nuclear speck|protein kinase binding|multicellular organism growth|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein complex|embryonic organ development|somite development|ubiquitin protein ligase activity RBBP7 3311.26220086043 3327.94622705626 3294.57817466459 0.989973379942145 -0.0145383627676353 0.913841059411665 1 50.7739 51.8759 55.4763 48.6006 GeneID:5931,Genbank:NM_002893.3,HGNC:HGNC:9890,MIM:300825 RB binding protein 7, chromatin remodeling factor RBBP8 477.330726673466 498.084670823764 456.576782523168 0.916664995467642 -0.125533512301396 0.666795422996763 1 3.55267 2.74627 3.40492 2.4691 GeneID:5932,Genbank:XM_011526132.2,HGNC:HGNC:9891,MIM:604124 RB binding protein 8, endonuclease hsa03440 Homologous recombination RBBP9 545.472556853201 568.068828754297 522.876284952105 0.920445302550233 -0.119596102898434 0.48436012896364 1 5.39576 5.87274 4.97515 5.57129 GeneID:10741,Genbank:XM_005260652.2,HGNC:HGNC:9892,MIM:602908 RB binding protein 9, serine hydrolase GO:0005654,GO:0005737,GO:0016787,GO:0042127,GO:0070062 nucleoplasm|cytoplasm|hydrolase activity|regulation of cell proliferation|extracellular exosome RBCK1 1176.22175485633 1030.29509434348 1322.14841536918 1.2832715817323 0.359826523627655 0.0175781226329244 0.545603124203327 6.29634 7.09825 9.87377 8.24434 GeneID:10616,Genbank:NM_031229.3,HGNC:HGNC:15864,MIM:610924 RANBP2-type and C3HC4-type zinc finger containing 1 GO:0000209,GO:0004842,GO:0005829,GO:0007249,GO:0010803,GO:0016032,GO:0032088,GO:0042346,GO:0043123,GO:0043130,GO:0043161,GO:0046872,GO:0050852,GO:0051092,GO:0060546,GO:0071797,GO:0097039,GO:2001238 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|I-kappaB kinase/NF-kappaB signaling|regulation of tumor necrosis factor-mediated signaling pathway|viral process|negative regulation of NF-kappaB transcription factor activity|positive regulation of NF-kappaB import into nucleus|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|negative regulation of necroptotic process|LUBAC complex|protein linear polyubiquitination|positive regulation of extrinsic apoptotic signaling pathway hsa04217,hsa04621 Necroptosis|NOD-like receptor signaling pathway RBFA 253.98952975548 239.986840131634 267.992219379327 1.11669547893681 0.159235818834033 0.47317414321628 1 1.42599 1.76231 1.75084 1.87865 GeneID:79863,Genbank:NM_024805.2,HGNC:HGNC:26120 ribosome binding factor A GO:0005739,GO:0006364 mitochondrion|rRNA processing RBFOX1 1.46521110650189 1.96028560782945 0.97013660517434 0.494895540374107 -1.01480405310505 0.813633116358399 1 0 0.00705853 0.0036012 0 GeneID:54715,Genbank:XM_017023318.2,HGNC:HGNC:18222,MIM:605104 RNA binding fox-1 homolog 1 GO:0000381,GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0005802,GO:0006397,GO:0007399,GO:0008022,GO:0008380,GO:0050658 regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|cytoplasm|trans-Golgi network|mRNA processing|nervous system development|protein C-terminus binding|RNA splicing|RNA transport RBFOX2 2408.21922300758 2587.66245646279 2228.77598955238 0.861308623922691 -0.215397818447289 0.122653058437675 1 8.12539 7.98882 6.96457 6.92948 GeneID:23543,Genbank:NM_001082579.2,HGNC:HGNC:9906,MIM:612149 RNA binding fox-1 homolog 2 GO:0000381,GO:0003714,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006397,GO:0007399,GO:0008134,GO:0008380,GO:0008543,GO:0010724,GO:0016070,GO:0021942,GO:0030520,GO:0042127,GO:0045892,GO:0048813,GO:0050885 regulation of alternative mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|mRNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|mRNA processing|nervous system development|transcription factor binding|RNA splicing|fibroblast growth factor receptor signaling pathway|regulation of definitive erythrocyte differentiation|RNA metabolic process|radial glia guided migration of Purkinje cell|intracellular estrogen receptor signaling pathway|regulation of cell proliferation|negative regulation of transcription, DNA-templated|dendrite morphogenesis|neuromuscular process controlling balance RBFOX3 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0128796 0 GeneID:146713,Genbank:NM_001350453.1,HGNC:HGNC:27097,MIM:616999 RNA binding fox-1 homolog 3 GO:0000381,GO:0003677,GO:0003729,GO:0005634,GO:0005737,GO:0006397,GO:0007399,GO:0008380,GO:0043204 regulation of alternative mRNA splicing, via spliceosome|DNA binding|mRNA binding|nucleus|cytoplasm|mRNA processing|nervous system development|RNA splicing|perikaryon RBKS 42.0392995754298 46.7674885940503 37.3111105568092 0.79780017440483 -0.325900656078787 0.450910494940856 1 0.457976 0.443303 0.341215 0.362488 GeneID:64080,Genbank:NM_022128.2,HGNC:HGNC:30325,MIM:611132 ribokinase GO:0004747,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006098,GO:0019200,GO:0019303,GO:0046835,GO:0046872,GO:0070062 ribokinase activity|ATP binding|nucleus|cytoplasm|cytosol|pentose-phosphate shunt|carbohydrate kinase activity|D-ribose catabolic process|carbohydrate phosphorylation|metal ion binding|extracellular exosome hsa00030 Pentose phosphate pathway RBL1 404.548781058018 396.603707000723 412.493855115313 1.04006555620662 0.0566744655139356 0.848613960240903 1 2.21079 1.75778 2.62871 1.62244 GeneID:5933,Genbank:NM_001323281.1,HGNC:HGNC:9893,MIM:116957 RB transcriptional corepressor like 1 GO:0000122,GO:0005654,GO:0005667,GO:0006351,GO:0007049,GO:0008134,GO:0010629,GO:0016032,GO:0016569,GO:0043550,GO:0045944,GO:0051726,GO:1990841,GO:2000773 negative regulation of transcription from RNA polymerase II promoter|nucleoplasm|transcription factor complex|transcription, DNA-templated|cell cycle|transcription factor binding|negative regulation of gene expression|viral process|covalent chromatin modification|regulation of lipid kinase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle|promoter-specific chromatin binding|negative regulation of cellular senescence hsa04110,hsa04218,hsa04350,hsa05165,hsa05203 Cell cycle|Cellular senescence|TGF-beta signaling pathway|Human papillomavirus infection|Viral carcinogenesis RBL2 1631.60672129399 1696.27604893475 1566.93739365324 0.923751411002512 -0.114423431953583 0.527374355423856 1 11.5143 10.3737 11.3147 8.96518 GeneID:5934,Genbank:NM_001323608.1,HGNC:HGNC:9894,MIM:180203 RB transcriptional corepressor like 2 hsa04068,hsa04110,hsa04151,hsa04218,hsa05165,hsa05203 FoxO signaling pathway|Cell cycle|PI3K-Akt signaling pathway|Cellular senescence|Human papillomavirus infection|Viral carcinogenesis RBM10 1360.35304411248 1325.063053289 1395.64303493596 1.05326537591685 0.0748689769939872 0.658182074248581 1 9.15108 9.98866 9.7772 10.6048 GeneID:8241,Genbank:XM_005272677.4,HGNC:HGNC:9896,MIM:300080 RNA binding motif protein 10 GO:0000381,GO:0003723,GO:0005634,GO:0006397,GO:0008380,GO:0016607,GO:0032403,GO:0035198,GO:0042802,GO:0042981,GO:0046872 regulation of alternative mRNA splicing, via spliceosome|RNA binding|nucleus|mRNA processing|RNA splicing|nuclear speck|protein complex binding|miRNA binding|identical protein binding|regulation of apoptotic process|metal ion binding RBM12 1575.08248344557 1645.86837211975 1504.29659477138 0.913983536140236 -0.129759917068747 0.377529430750218 1 14.279 13.9009 13.524 12.5484 GeneID:10137,Genbank:NM_001198838.1,HGNC:HGNC:9898,MIM:607179 RNA binding motif protein 12 GO:0003723,GO:0005654 RNA binding|nucleoplasm RBM12B 448.797618518581 467.672851938793 429.922385098369 0.919280183393315 -0.121423453627988 0.556822581866884 1 2.23809 2.21377 2.45693 1.69178 GeneID:389677,Genbank:XM_011517029.2,HGNC:HGNC:32310 RNA binding motif protein 12B GO:0003723 RNA binding RBM14 1419.71711338941 1418.98224067458 1420.45198610423 1.00103577436526 0.00149353319200279 0.982394569671915 1 15.201 16.8405 16.3287 15.6281 GeneID:10432,Genbank:NM_006328.3,HGNC:HGNC:14219,MIM:612409 RNA binding motif protein 14 GO:0003723,GO:0005634,GO:0005730,GO:0005737,GO:0006351,GO:0006355,GO:0045087,GO:0098534 RNA binding|nucleus|nucleolus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|innate immune response|centriole assembly RBM15 304.359966609532 299.495168175721 309.224765043343 1.03248665722017 0.0461231378803915 0.816729728638095 1 3.28749 3.08811 3.85 2.88649 GeneID:64783,Genbank:NM_022768.4,HGNC:HGNC:14959,MIM:606077 RNA binding motif protein 15 RBM15B 3586.88991842467 3234.22997042538 3939.54986642396 1.21807969824292 0.284608531026021 0.0358668237166167 0.738653561785664 20.3568 20.8274 26.1921 24.9232 GeneID:29890,Genbank:NM_013286.4,HGNC:HGNC:24303,MIM:612602 RNA binding motif protein 15B GO:0000381,GO:0003676,GO:0003723,GO:0005654,GO:0006351,GO:0006355,GO:0006397,GO:0008380,GO:0016032 regulation of alternative mRNA splicing, via spliceosome|nucleic acid binding|RNA binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA processing|RNA splicing|viral process RBM17 1416.36517264725 1501.3778117849 1331.35253350959 0.886753835749594 -0.173394429180014 0.235238641698875 1 13.7762 13.8445 13.4722 11.2854 GeneID:84991,Genbank:NM_032905.4,HGNC:HGNC:16944,MIM:606935 RNA binding motif protein 17 GO:0000380,GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0006281,GO:0043234,GO:0043484 alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|DNA repair|protein complex|regulation of RNA splicing hsa03040 Spliceosome RBM18 428.511187936278 463.482723384386 393.539652488171 0.84909238820061 -0.236006555541109 0.209864827356923 1 6.84838 5.70282 5.67879 4.90771 GeneID:92400,Genbank:NM_033117.3,HGNC:HGNC:28413 RNA binding motif protein 18 GO:0003723 RNA binding RBM19 707.078227492499 688.16269719661 725.993757788387 1.05497400650441 0.0772074528195005 0.634229496416074 1 3.56514 3.37463 3.93585 3.44295 GeneID:9904,Genbank:NM_001146699.1,HGNC:HGNC:29098,MIM:616444 RNA binding motif protein 19 GO:0003723,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0007275,GO:0016020,GO:0040019 RNA binding|nucleoplasm|chromosome|nucleolus|cytoplasm|multicellular organism development|membrane|positive regulation of embryonic development RBM20 294.166653512733 287.359052986372 300.974254039094 1.04738044934108 0.066785580453736 0.745461351121462 1 0.773549 0.768867 0.922964 0.774949 GeneID:282996,Genbank:XM_017016103.2,HGNC:HGNC:27424,MIM:613171 RNA binding motif protein 20 GO:0003723,GO:0005634,GO:0006397,GO:0007507,GO:0008270,GO:0008380,GO:0033120 RNA binding|nucleus|mRNA processing|heart development|zinc ion binding|RNA splicing|positive regulation of RNA splicing RBM22 1678.58775343878 1768.14507423481 1589.03043264274 0.898699125879371 -0.154089896004601 0.28025941281271 1 22.6908 23.139 20.18 20.9542 GeneID:55696,Genbank:NM_018047.2,HGNC:HGNC:25503,MIM:612430 RNA binding motif protein 22 GO:0000060,GO:0000387,GO:0000398,GO:0000974,GO:0003723,GO:0005487,GO:0005634,GO:0005654,GO:0005737,GO:0017070,GO:0033120,GO:0035690,GO:0036002,GO:0045292,GO:0046872,GO:0048306,GO:0071006,GO:0071007,GO:0071013,GO:0090316 protein import into nucleus, translocation|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|Prp19 complex|RNA binding|nucleocytoplasmic transporter activity|nucleus|nucleoplasm|cytoplasm|U6 snRNA binding|positive regulation of RNA splicing|cellular response to drug|pre-mRNA binding|mRNA cis splicing, via spliceosome|metal ion binding|calcium-dependent protein binding|U2-type catalytic step 1 spliceosome|U2-type catalytic step 2 spliceosome|catalytic step 2 spliceosome|positive regulation of intracellular protein transport hsa03040 Spliceosome RBM23 1699.56333418508 1668.07648968785 1731.05017868232 1.03775227897748 0.053462100205456 0.714600828703013 1 7.56818 7.54842 7.8191 7.99154 GeneID:55147,Genbank:NM_001308044.1,HGNC:HGNC:20155 RNA binding motif protein 23 GO:0003723,GO:0005634,GO:0006397,GO:0016020 RNA binding|nucleus|mRNA processing|membrane RBM24 1142.04918330648 1267.80011749829 1016.29824911467 0.801623406629824 -0.319003460436376 0.0343189622563168 0.729950198535418 15.1424 14.472 12.907 11.4229 GeneID:221662,Genbank:XM_005248932.3,HGNC:HGNC:21539,MIM:617603 RNA binding motif protein 24 GO:0003730,GO:0005654,GO:0005829,GO:0010830,GO:0030154,GO:0043488 mRNA 3'-UTR binding|nucleoplasm|cytosol|regulation of myotube differentiation|cell differentiation|regulation of mRNA stability RBM25 722.161863243502 773.047859937148 671.275866549857 0.868349686142893 -0.203651959048339 0.335495786408169 1 4.55308 3.89525 4.179 3.19432 GeneID:58517,Genbank:NM_021239.2,HGNC:HGNC:23244,MIM:612427 RNA binding motif protein 25 GO:0000381,GO:0003723,GO:0003729,GO:0005681,GO:0005737,GO:0006397,GO:0008380,GO:0016607,GO:0042981 regulation of alternative mRNA splicing, via spliceosome|RNA binding|mRNA binding|spliceosomal complex|cytoplasm|mRNA processing|RNA splicing|nuclear speck|regulation of apoptotic process hsa03040 Spliceosome RBM26 451.923110593475 513.200449045288 390.645772141662 0.761195304619051 -0.393661432413239 0.0290315605159227 0.674846840672015 1.59516 1.46641 1.39303 1.07635 GeneID:64062,Genbank:XM_017020697.2,HGNC:HGNC:20327 RNA binding motif protein 26 GO:0003723,GO:0006397,GO:0010923,GO:0046872 RNA binding|mRNA processing|negative regulation of phosphatase activity|metal ion binding RBM27 512.483168414875 573.718345858614 451.247990971136 0.786532266622586 -0.346422143052468 0.069105596035848 0.918407228165493 2.95926 2.79508 2.69998 1.87379 GeneID:54439,Genbank:XM_005268466.1,HGNC:HGNC:29243 RNA binding motif protein 27 GO:0003723,GO:0005737,GO:0006397,GO:0016607,GO:0046872 RNA binding|cytoplasm|mRNA processing|nuclear speck|metal ion binding RBM28 1140.08727123794 1224.15637076047 1056.0181717154 0.862649737352902 -0.213153195689811 0.15537266863871 1 4.5277 4.56725 4.05151 3.68582 GeneID:55131,Genbank:XM_017012389.1,HGNC:HGNC:21863,MIM:612074 RNA binding motif protein 28 GO:0003723,GO:0005681,GO:0005730,GO:0006397,GO:0008380 RNA binding|spliceosomal complex|nucleolus|mRNA processing|RNA splicing hsa03008 Ribosome biogenesis in eukaryotes RBM3 6461.07456973297 6625.25707016178 6296.89206930417 0.950437394748581 -0.0733364951154668 0.581548663213278 1 49.5552 49.5845 45.3402 49.3962 GeneID:5935,Genbank:NM_006743.4,HGNC:HGNC:9900,MIM:300027 RNA binding motif protein 3 GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006396,GO:0006417,GO:0030425,GO:0045727 RNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|RNA processing|regulation of translation|dendrite|positive regulation of translation RBM33 1132.17942173118 1225.24237476886 1039.1164686935 0.848090541179267 -0.23770980139903 0.112361337950673 1 4.35035 4.32666 4.22524 3.37802 GeneID:155435,Genbank:XM_005249531.1,HGNC:HGNC:27223 RNA binding motif protein 33 GO:0003723 RNA binding RBM34 683.018589209557 687.538355625706 678.498822793407 0.986852322116528 -0.0190938866906158 0.907744765609369 1 9.16918 9.73822 9.85073 8.96983 GeneID:23029,Genbank:NM_001346738.1,HGNC:HGNC:28965 RNA binding motif protein 34 GO:0003723,GO:0005634,GO:0005730 RNA binding|nucleus|nucleolus RBM38 942.229297085929 949.174581337726 935.284012834132 0.985365633702478 -0.0212689387960168 0.879277946800713 1 13.9976 14.2601 13.9673 15.1082 GeneID:55544,Genbank:NM_001291780.1,HGNC:HGNC:15818,MIM:612428 RNA binding motif protein 38 GO:0003723,GO:0003729,GO:0003730,GO:0005634,GO:0005829,GO:0006397,GO:0006977,GO:0006978,GO:0007049,GO:0007050,GO:0008285,GO:0008380,GO:0010830,GO:0030154,GO:0043484,GO:0070935 RNA binding|mRNA binding|mRNA 3'-UTR binding|nucleus|cytosol|mRNA processing|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|cell cycle|cell cycle arrest|negative regulation of cell proliferation|RNA splicing|regulation of myotube differentiation|cell differentiation|regulation of RNA splicing|3'-UTR-mediated mRNA stabilization RBM39 2332.64857854703 2548.78210257303 2116.51505452103 0.830402509647401 -0.26811729106345 0.0576496538580736 0.87105363791595 16.6825 15.8095 15.5393 12.4801 GeneID:9584,Genbank:NM_001242600.1,HGNC:HGNC:15923,MIM:604739 RNA binding motif protein 39 GO:0003723,GO:0005654,GO:0005815,GO:0006351,GO:0006355,GO:0006396,GO:0006397,GO:0008380,GO:0015630,GO:0016607,GO:0043234 RNA binding|nucleoplasm|microtubule organizing center|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA processing|mRNA processing|RNA splicing|microtubule cytoskeleton|nuclear speck|protein complex RBM4 667.0801205346 626.646057270009 707.514183799191 1.12904912684121 0.175108261583209 0.293987479536915 1 9.87103 10.496 10.4779 11.514 GeneID:5936,Genbank:NM_001198844.1,HGNC:HGNC:9901,MIM:602571 RNA binding motif protein 4 GO:0000381,GO:0002190,GO:0002192,GO:0003723,GO:0003729,GO:0003730,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006396,GO:0006397,GO:0008270,GO:0008380,GO:0010494,GO:0016607,GO:0017148,GO:0030154,GO:0030332,GO:0032055,GO:0035198,GO:0035278,GO:0043153,GO:0045947,GO:0046685,GO:0046822,GO:0051149,GO:0097157,GO:0097158,GO:0097167 regulation of alternative mRNA splicing, via spliceosome|cap-independent translational initiation|IRES-dependent translational initiation of linear mRNA|RNA binding|mRNA binding|mRNA 3'-UTR binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|RNA processing|mRNA processing|zinc ion binding|RNA splicing|cytoplasmic stress granule|nuclear speck|negative regulation of translation|cell differentiation|cyclin binding|negative regulation of translation in response to stress|miRNA binding|miRNA mediated inhibition of translation|entrainment of circadian clock by photoperiod|negative regulation of translational initiation|response to arsenic-containing substance|regulation of nucleocytoplasmic transport|positive regulation of muscle cell differentiation|pre-mRNA intronic binding|pre-mRNA intronic pyrimidine-rich binding|circadian regulation of translation RBM41 148.176503719446 143.203659573463 153.149347865429 1.06945135565383 0.0968708625375304 0.696121229375541 1 0.508911 0.441238 0.55577 0.487769 GeneID:55285,Genbank:NM_001171080.1,HGNC:HGNC:25617 RNA binding motif protein 41 GO:0000398,GO:0005689,GO:0030626,GO:0032502,GO:0097157 mRNA splicing, via spliceosome|U12-type spliceosomal complex|U12 snRNA binding|developmental process|pre-mRNA intronic binding RBM42 2419.60452753529 2375.4872587306 2463.72179633999 1.03714376378366 0.0526158873258667 0.71667071302072 1 64.3991 63.6767 65.7477 69.7926 GeneID:79171,Genbank:NM_024321.4,HGNC:HGNC:28117,MIM:613232 RNA binding motif protein 42 GO:0003723,GO:0005634,GO:0005737 RNA binding|nucleus|cytoplasm RBM43 87.3146082021698 86.8944916239063 87.7347247804332 1.00966957905875 0.0138832388722303 0.964446600282044 1 0.928113 0.672994 1.07695 0.625597 GeneID:375287,Genbank:NM_198557.2,HGNC:HGNC:24790 RNA binding motif protein 43 GO:0003723 RNA binding RBM44 6.29581029559253 8.71542403075469 3.87619656043037 0.444751345058162 -1.16892912625652 0.345313260022869 1 0.0440775 0.0429008 0.0142239 0.00661217 GeneID:375316,Genbank:XM_017004055.1,HGNC:HGNC:24756 RNA binding motif protein 44 GO:0003723,GO:0005737,GO:0042803,GO:0045171 RNA binding|cytoplasm|protein homodimerization activity|intercellular bridge RBM45 134.434365961264 153.053113887295 115.815618035232 0.756702134923668 -0.402202579399796 0.130369130938976 1 1.59948 1.87316 1.40889 1.55236 GeneID:129831,Genbank:XM_017003321.1,HGNC:HGNC:24468,MIM:608888 RNA binding motif protein 45 GO:0003723,GO:0005634,GO:0005737,GO:0007399,GO:0030154 RNA binding|nucleus|cytoplasm|nervous system development|cell differentiation RBM47 389.61784577526 359.955230059253 419.280461491266 1.1648128058099 0.220098121549728 0.475317272399099 1 1.49006 1.41138 2.09377 1.34235 GeneID:54502,Genbank:NM_001098634.1,HGNC:HGNC:30358 RNA binding motif protein 47 GO:0002244,GO:0003723,GO:0005634,GO:0016554 hematopoietic progenitor cell differentiation|RNA binding|nucleus|cytidine to uridine editing RBM48 273.184814002904 289.049781255453 257.319846750356 0.89022674790729 -0.1677552459805 0.437315618386539 1 1.71784 1.54988 1.3029 1.4142 GeneID:84060,Genbank:NM_032120.3,HGNC:HGNC:21785 RNA binding motif protein 48 GO:0003723,GO:0005654 RNA binding|nucleoplasm RBM4B 307.158257280187 319.665547895981 294.650966664393 0.921747647201168 -0.117556266102079 0.534442107133633 1 3.70358 4.7516 3.84267 3.92279 GeneID:83759,Genbank:NM_001286135.1,HGNC:HGNC:28842 RNA binding motif protein 4B GO:0003723,GO:0005654,GO:0005730,GO:0005829,GO:0006397,GO:0006417,GO:0007623,GO:0008270,GO:0008380,GO:0010628,GO:0032922,GO:0043153,GO:0043234 RNA binding|nucleoplasm|nucleolus|cytosol|mRNA processing|regulation of translation|circadian rhythm|zinc ion binding|RNA splicing|positive regulation of gene expression|circadian regulation of gene expression|entrainment of circadian clock by photoperiod|protein complex RBM5 1999.451152981 1974.066030602 2024.83627536 1.02571861526968 0.0366350116152929 0.784867098989325 1 15.1195 14.4653 16.1486 14.3144 GeneID:10181,Genbank:NM_005778.3,HGNC:HGNC:9902,MIM:606884 RNA binding motif protein 5 RBM6 1566.76381153133 1644.25509609068 1489.27252697198 0.905742989948958 -0.142826359988552 0.322470135005501 1 7.48669 7.63509 7.5012 6.81549 GeneID:10180,Genbank:XM_005264784.1,HGNC:HGNC:9903,MIM:606886 RNA binding motif protein 6 GO:0003677,GO:0003723,GO:0005634,GO:0006396 DNA binding|RNA binding|nucleus|RNA processing RBM7 409.720079761981 410.383541185322 409.05661833864 0.996766627523976 -0.00467232820245383 1 1 5.08283 4.82174 5.45801 4.52737 GeneID:10179,Genbank:NM_001286045.1,HGNC:HGNC:9904,MIM:612413 RNA binding motif protein 7 GO:0000381,GO:0003723,GO:0003727,GO:0005634,GO:0005654,GO:0051321 regulation of alternative mRNA splicing, via spliceosome|RNA binding|single-stranded RNA binding|nucleus|nucleoplasm|meiotic cell cycle RBM8A 3116.4660519002 3246.68163522645 2986.25046857394 0.919785431430406 -0.120630747973558 0.377614336178151 1 24.1064 24.7091 22.8622 22.4501 GeneID:9939,Genbank:NM_005105.4,HGNC:HGNC:9905,MIM:605313 RNA binding motif protein 8A GO:0000184,GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006369,GO:0006405,GO:0006406,GO:0006417,GO:0016607,GO:0030425,GO:0031124,GO:0035145,GO:0043025,GO:0071013 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|regulation of translation|nuclear speck|dendrite|mRNA 3'-end processing|exon-exon junction complex|neuronal cell body|catalytic step 2 spliceosome hsa03013,hsa03015,hsa03040 RNA transport|mRNA surveillance pathway|Spliceosome RBMS1 907.26249283895 994.430587103762 820.094398574138 0.824687423345081 -0.278080688547344 0.258396442979765 1 8.74699 7.21081 7.74274 5.63101 GeneID:5937,Genbank:XM_017004626.2,HGNC:HGNC:9907,MIM:602310 RNA binding motif single stranded interacting protein 1 GO:0003690,GO:0003697,GO:0003723,GO:0005634,GO:0005829,GO:0006260,GO:0006396 double-stranded DNA binding|single-stranded DNA binding|RNA binding|nucleus|cytosol|DNA replication|RNA processing RBMS2 632.178373991313 627.50072155923 636.856026423396 1.01490883522958 0.0213501423177609 0.901318584027912 1 2.30134 2.26794 2.57529 2.04354 GeneID:5939,Genbank:XM_024449115.1,HGNC:HGNC:9909,MIM:602387 RNA binding motif single stranded interacting protein 2 GO:0003723,GO:0005634,GO:0006396 RNA binding|nucleus|RNA processing RBMS3 110.571243587047 114.510977922043 106.631509252051 0.93119027701121 -0.10285210040936 0.753360991214008 1 0.462208 0.349728 0.442434 0.337116 GeneID:27303,Genbank:XM_017006182.1,HGNC:HGNC:13427,MIM:605786 RNA binding motif single stranded interacting protein 3 GO:0003723,GO:0005737 RNA binding|cytoplasm RBMX 5694.12714113598 5904.7192174698 5483.53506480215 0.928669910091317 -0.106762204090869 0.428574464990703 1 56.721 55.1215 53.5066 52.1005 GeneID:27316,Genbank:NM_001164803.1,HGNC:HGNC:9910,MIM:300199 RNA binding motif protein, X-linked GO:0000381,GO:0000398,GO:0001047,GO:0001649,GO:0003682,GO:0003723,GO:0003727,GO:0003729,GO:0005615,GO:0005634,GO:0005654,GO:0005719,GO:0006366,GO:0006376,GO:0006509,GO:0016020,GO:0016070,GO:0019904,GO:0030529,GO:0042802,GO:0044530,GO:0045944,GO:0048025,GO:0048026,GO:0051259,GO:0051260,GO:0070062,GO:0071013,GO:0071347 regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|core promoter binding|osteoblast differentiation|chromatin binding|RNA binding|single-stranded RNA binding|mRNA binding|extracellular space|nucleus|nucleoplasm|nuclear euchromatin|transcription from RNA polymerase II promoter|mRNA splice site selection|membrane protein ectodomain proteolysis|membrane|RNA metabolic process|protein domain specific binding|intracellular ribonucleoprotein complex|identical protein binding|supraspliceosomal complex|positive regulation of transcription from RNA polymerase II promoter|negative regulation of mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|protein oligomerization|protein homooligomerization|extracellular exosome|catalytic step 2 spliceosome|cellular response to interleukin-1 hsa03040 Spliceosome RBMX2 949.699781528051 956.380556542176 943.019006513925 0.986029044675939 -0.0202979513340847 0.900900410917461 1 16.4183 17.4661 15.8833 17.5842 GeneID:51634,Genbank:NM_016024.3,HGNC:HGNC:24282 RNA binding motif protein, X-linked 2 GO:0000398,GO:0003723,GO:0005686,GO:0006406,GO:0070274,GO:0071011,GO:0071013 mRNA splicing, via spliceosome|RNA binding|U2 snRNP|mRNA export from nucleus|RES complex|precatalytic spliceosome|catalytic step 2 spliceosome RBMXL1 318.363448936684 329.926604370907 306.80029350246 0.92990468012562 -0.104845254535447 0.651835863970779 1 2.88352 2.44955 2.88823 2.17704 GeneID:494115,Genbank:NM_019610.5,HGNC:HGNC:25073 RNA binding motif protein, X-linked like 1 GO:0003723,GO:0005634,GO:0006397,GO:0008380,GO:0030529 RNA binding|nucleus|mRNA processing|RNA splicing|intracellular ribonucleoprotein complex hsa03040 Spliceosome RBP1 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0251017 0 0 0 GeneID:5947,Genbank:NM_002899.3,HGNC:HGNC:9919,MIM:180260 retinol binding protein 1 GO:0001523,GO:0002138,GO:0005501,GO:0005654,GO:0005811,GO:0005829,GO:0006776,GO:0016918,GO:0055088,GO:1904768 retinoid metabolic process|retinoic acid biosynthetic process|retinoid binding|nucleoplasm|lipid droplet|cytosol|vitamin A metabolic process|retinal binding|lipid homeostasis|all-trans-retinol binding RBP4 3.99106491567603 3.6226049124413 4.35952491891075 1.20342268182175 0.267143453706376 0.943351939067802 1 0.142373 0.123624 0.0876882 0.123063 GeneID:5950,Genbank:NM_001323518.1,HGNC:HGNC:9922,MIM:180250 retinol binding protein 4 GO:0001654,GO:0005615,GO:0006094,GO:0016918,GO:0019841,GO:0030277,GO:0032024,GO:0032526,GO:0034632,GO:0042572,GO:0042593 eye development|extracellular space|gluconeogenesis|retinal binding|retinol binding|maintenance of gastrointestinal epithelium|positive regulation of insulin secretion|response to retinoic acid|retinol transmembrane transporter activity|retinol metabolic process|glucose homeostasis RBPJ 646.736385588792 633.294317487602 660.178453689983 1.0424512512745 0.0599799196997455 0.824870605312416 1 4.09896 3.80415 5.07649 3.3278 GeneID:3516,Genbank:XM_005248161.4,HGNC:HGNC:5724,MIM:147183 recombination signal binding protein for immunoglobulin kappa J region GO:0000122,GO:0000150,GO:0000978,GO:0001077,GO:0001103,GO:0001525,GO:0001756,GO:0001837,GO:0001974,GO:0002193,GO:0002437,GO:0003139,GO:0003151,GO:0003160,GO:0003198,GO:0003214,GO:0003222,GO:0003256,GO:0003677,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005737,GO:0006310,GO:0006367,GO:0006959,GO:0007219,GO:0007221,GO:0008134,GO:0008285,GO:0009912,GO:0009957,GO:0017053,GO:0021983,GO:0030183,GO:0030216,GO:0030279,GO:0030513,GO:0035019,GO:0035912,GO:0036302,GO:0042742,GO:0043011,GO:0043565,GO:0045596,GO:0045747,GO:0045892,GO:0045944,GO:0047485,GO:0048505,GO:0048733,GO:0048820,GO:0060045,GO:0060486,GO:0060716,GO:0060844,GO:0061314,GO:0061419,GO:0070491,GO:0072554,GO:0072602,GO:0097101,GO:1901186,GO:1901189,GO:1901297,GO:2000138 negative regulation of transcription from RNA polymerase II promoter|recombinase activity|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II repressing transcription factor binding|angiogenesis|somitogenesis|epithelial to mesenchymal transition|blood vessel remodeling|MAML1-RBP-Jkappa- ICN1 complex|inflammatory response to antigenic stimulus|secondary heart field specification|outflow tract morphogenesis|endocardium morphogenesis|epithelial to mesenchymal transition involved in endocardial cushion formation|cardiac left ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|DNA binding|chromatin binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|nucleolus|cytoplasm|DNA recombination|transcription initiation from RNA polymerase II promoter|humoral immune response|Notch signaling pathway|positive regulation of transcription of Notch receptor target|transcription factor binding|negative regulation of cell proliferation|auditory receptor cell fate commitment|epidermal cell fate specification|transcriptional repressor complex|pituitary gland development|B cell differentiation|keratinocyte differentiation|negative regulation of ossification|positive regulation of BMP signaling pathway|somatic stem cell population maintenance|dorsal aorta morphogenesis|atrioventricular canal development|defense response to bacterium|myeloid dendritic cell differentiation|sequence-specific DNA binding|negative regulation of cell differentiation|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein N-terminus binding|regulation of timing of cell differentiation|sebaceous gland development|hair follicle maturation|positive regulation of cardiac muscle cell proliferation|Clara cell differentiation|labyrinthine layer blood vessel development|arterial endothelial cell fate commitment|Notch signaling involved in heart development|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|repressing transcription factor binding|blood vessel lumenization|interleukin-4 secretion|blood vessel endothelial cell fate specification|positive regulation of ERBB signaling pathway|positive regulation of ephrin receptor signaling pathway|positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|positive regulation of cell proliferation involved in heart morphogenesis hsa04330,hsa04658,hsa05165,hsa05169,hsa05203 Notch signaling pathway|Th1 and Th2 cell differentiation|Human papillomavirus infection|Epstein-Barr virus infection|Viral carcinogenesis RBPMS 378.895782927176 355.064324694787 402.727241159565 1.13423741319477 0.181722649971014 0.326654089892177 1 1.12478 1.17795 1.45739 1.34472 GeneID:11030,Genbank:NM_001008711.2,HGNC:HGNC:19097,MIM:601558 RNA binding protein, mRNA processing factor GO:0000398,GO:0000932,GO:0003713,GO:0003723,GO:0005654,GO:0005685,GO:0005829,GO:0006351,GO:0006355,GO:0006396,GO:0006979,GO:0008143,GO:0010494,GO:0010862,GO:0030619,GO:0035614,GO:0042803,GO:0060391 mRNA splicing, via spliceosome|P-body|transcription coactivator activity|RNA binding|nucleoplasm|U1 snRNP|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA processing|response to oxidative stress|poly(A) binding|cytoplasmic stress granule|positive regulation of pathway-restricted SMAD protein phosphorylation|U1 snRNA binding|snRNA stem-loop binding|protein homodimerization activity|positive regulation of SMAD protein import into nucleus RBPMS2 154.8353368278 176.40303639187 133.267637263729 0.755472467989054 -0.404548915300594 0.109749086591348 1 4.70506 3.92406 3.24769 3.44064 GeneID:348093,Genbank:NM_194272.2,HGNC:HGNC:19098 RNA binding protein, mRNA processing factor 2 GO:0003729,GO:0005737,GO:0030514,GO:0042803,GO:0048557,GO:0048661,GO:0051151 mRNA binding|cytoplasm|negative regulation of BMP signaling pathway|protein homodimerization activity|embryonic digestive tract morphogenesis|positive regulation of smooth muscle cell proliferation|negative regulation of smooth muscle cell differentiation RBSN 1235.09114726845 1300.81821487392 1169.36407966297 0.898945038047698 -0.153695183552525 0.294656996639664 1 6.0039 6.64042 5.56758 5.7234 GeneID:64145,Genbank:XM_017007026.1,HGNC:HGNC:20759,MIM:609511 rabenosyn, RAB effector GO:0000011,GO:0003676,GO:0005768,GO:0005829,GO:0005886,GO:0006895,GO:0006897,GO:0007596,GO:0008270,GO:0010008,GO:0010009,GO:0015031,GO:0016197,GO:0017137,GO:0031901,GO:0034058,GO:0034498,GO:0043231,GO:0070062,GO:0090160,GO:1903358 vacuole inheritance|nucleic acid binding|endosome|cytosol|plasma membrane|Golgi to endosome transport|endocytosis|blood coagulation|zinc ion binding|endosome membrane|cytoplasmic side of endosome membrane|protein transport|endosomal transport|Rab GTPase binding|early endosome membrane|endosomal vesicle fusion|early endosome to Golgi transport|intracellular membrane-bounded organelle|extracellular exosome|Golgi to lysosome transport|regulation of Golgi organization hsa04144 Endocytosis RBX1 870.923073122822 937.922556402922 803.923589842723 0.857132163369536 -0.222410420611423 0.194796589537792 1 45.5387 53.3375 40.2316 47.0585 GeneID:9978,Genbank:NM_014248.3,HGNC:HGNC:9928,MIM:603814 ring-box 1 hsa03420,hsa04066,hsa04110,hsa04114,hsa04120,hsa04141,hsa04310,hsa04350,hsa04710,hsa05170,hsa05200,hsa05211 Nucleotide excision repair|HIF-1 signaling pathway|Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Wnt signaling pathway|TGF-beta signaling pathway|Circadian rhythm|Human immunodeficiency virus 1 infection|Pathways in cancer|Renal cell carcinoma RC3H1 180.750160425803 190.365167020101 171.135153831504 0.898983550984585 -0.153633376400222 0.779997452421061 1 0.670628 0.719228 0.914293 0.3887 GeneID:149041,Genbank:NM_001300852.1,HGNC:HGNC:29434,MIM:609424 ring finger and CCCH-type domains 1 GO:0000288,GO:0000932,GO:0000956,GO:0001782,GO:0002634,GO:0002635,GO:0003723,GO:0003730,GO:0010494,GO:0010608,GO:0030889,GO:0033962,GO:0035613,GO:0042098,GO:0043029,GO:0043488,GO:0045623,GO:0046007,GO:0046872,GO:0048535,GO:0048536,GO:0050856,GO:0061014,GO:0061158,GO:0061470,GO:0061630,GO:0071347,GO:1901224 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|P-body|nuclear-transcribed mRNA catabolic process|B cell homeostasis|regulation of germinal center formation|negative regulation of germinal center formation|RNA binding|mRNA 3'-UTR binding|cytoplasmic stress granule|posttranscriptional regulation of gene expression|negative regulation of B cell proliferation|cytoplasmic mRNA processing body assembly|RNA stem-loop binding|T cell proliferation|T cell homeostasis|regulation of mRNA stability|negative regulation of T-helper cell differentiation|negative regulation of activated T cell proliferation|metal ion binding|lymph node development|spleen development|regulation of T cell receptor signaling pathway|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|T follicular helper cell differentiation|ubiquitin protein ligase activity|cellular response to interleukin-1|positive regulation of NIK/NF-kappaB signaling RC3H2 963.437314975365 1028.23570518371 898.638924767017 0.873961991629593 -0.194357556213948 0.45058505467151 1 4.0587 3.70294 4.06817 2.75318 GeneID:54542,Genbank:NM_001354479.1,HGNC:HGNC:21461,MIM:615231 ring finger and CCCH-type domains 2 GO:0000209,GO:0000932,GO:0001782,GO:0003677,GO:0003723,GO:0003729,GO:0004842,GO:0009791,GO:0009986,GO:0010608,GO:0016020,GO:0035264,GO:0042098,GO:0043029,GO:0043231,GO:0046872,GO:0048286,GO:0048535,GO:0048536,GO:0060173,GO:0061470,GO:1901224 protein polyubiquitination|P-body|B cell homeostasis|DNA binding|RNA binding|mRNA binding|ubiquitin-protein transferase activity|post-embryonic development|cell surface|posttranscriptional regulation of gene expression|membrane|multicellular organism growth|T cell proliferation|T cell homeostasis|intracellular membrane-bounded organelle|metal ion binding|lung alveolus development|lymph node development|spleen development|limb development|T follicular helper cell differentiation|positive regulation of NIK/NF-kappaB signaling RCAN1 2200.46456911642 1822.06172010437 2578.86741812847 1.41535678493961 0.501165775304831 0.000341949403593788 0.0488987647139116 9.76096 10.2525 15.6869 12.7195 GeneID:1827,Genbank:NM_004414.6,HGNC:HGNC:3040,MIM:602917 regulator of calcineurin 1 GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0007165,GO:0007417,GO:0008015,GO:0008597,GO:0033173,GO:0042802,GO:0070884 DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|signal transduction|central nervous system development|blood circulation|calcium-dependent protein serine/threonine phosphatase regulator activity|calcineurin-NFAT signaling cascade|identical protein binding|regulation of calcineurin-NFAT signaling cascade hsa04919,hsa04921,hsa05167 Thyroid hormone signaling pathway|Oxytocin signaling pathway|Kaposi sarcoma-associated herpesvirus infection RCAN2 91.5807448129538 89.6242146275496 93.5372749983579 1.04366074935295 0.0616528280332692 0.931123281304913 1 0.618795 1.16072 0.998056 0.774675 GeneID:10231,Genbank:NM_001251973.1,HGNC:HGNC:3041,MIM:604876 regulator of calcineurin 2 GO:0003676,GO:0005622,GO:0019722 nucleic acid binding|intracellular|calcium-mediated signaling hsa04919 Thyroid hormone signaling pathway RCAN3 359.881699095005 311.189238237796 408.574159952213 1.3129443751522 0.39280579559714 0.0366346257771926 0.739899327172153 4.4341 3.92036 6.3276 4.98626 GeneID:11123,Genbank:NM_001251979.1,HGNC:HGNC:3042,MIM:605860 RCAN family member 3 GO:0003723,GO:0005737,GO:0008597,GO:0009653,GO:0019722,GO:0031013,GO:0070884 RNA binding|cytoplasm|calcium-dependent protein serine/threonine phosphatase regulator activity|anatomical structure morphogenesis|calcium-mediated signaling|troponin I binding|regulation of calcineurin-NFAT signaling cascade RCBTB1 468.473449831003 494.971754623496 441.975145038509 0.892930032693887 -0.163380960347342 0.376501363902981 1 3.35923 3.18768 3.1482 2.9915 GeneID:55213,Genbank:XM_011535134.1,HGNC:HGNC:18243,MIM:607867 RCC1 and BTB domain containing protein 1 GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0007049,GO:0016569 nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|covalent chromatin modification RCBTB2 103.851259247168 112.714388448484 94.9881300458524 0.842732958527889 -0.246852546093343 0.401927427141648 1 0.548717 0.644988 0.513748 0.509679 GeneID:1102,Genbank:NM_001352429.1,HGNC:HGNC:1914,MIM:603524 RCC1 and BTB domain containing protein 2 RCC1 3664.40889563452 3733.98880321058 3594.82898805847 0.96273159281237 -0.0547944605703014 0.673447509487832 1 37.8396 40.1172 37.8557 38.9333 GeneID:1104,Genbank:NM_001048199.2,HGNC:HGNC:1913,MIM:179710 regulator of chromosome condensation 1 GO:0000082,GO:0000790,GO:0000794,GO:0003682,GO:0005087,GO:0005634,GO:0005654,GO:0005737,GO:0007052,GO:0007059,GO:0007088,GO:0008536,GO:0016032,GO:0031491,GO:0031492,GO:0031965,GO:0042393,GO:0043199,GO:0043234,GO:0046982,GO:0051225,GO:0051290,GO:0051301 G1/S transition of mitotic cell cycle|nuclear chromatin|condensed nuclear chromosome|chromatin binding|Ran guanyl-nucleotide exchange factor activity|nucleus|nucleoplasm|cytoplasm|mitotic spindle organization|chromosome segregation|regulation of mitotic nuclear division|Ran GTPase binding|viral process|nucleosome binding|nucleosomal DNA binding|nuclear membrane|histone binding|sulfate binding|protein complex|protein heterodimerization activity|spindle assembly|protein heterotetramerization|cell division RCC1L 1948.26718710605 1711.29882560947 2185.23554860263 1.27694562510109 0.35269709350799 0.0130354098788001 0.469619029742344 13.8423 14.4473 19.6772 17.6681 GeneID:81554,Genbank:NM_148842.2,HGNC:HGNC:14948 RCC1 like GO:0003723,GO:0005739 RNA binding|mitochondrion RCC2 5777.18308539121 5208.63320195103 6345.7329688314 1.21831058605825 0.284881968914288 0.0315622654160316 0.705022653979306 56.8481 57.1585 72.2022 68.4538 GeneID:55920,Genbank:NM_018715.3,HGNC:HGNC:30297,MIM:609587 regulator of chromosome condensation 2 GO:0003723,GO:0005730,GO:0005829,GO:0005874,GO:0005886,GO:0007062,GO:0007229,GO:0008017,GO:0010762,GO:0010971,GO:0019901,GO:0019904,GO:0030334,GO:0030496,GO:0031267,GO:0031901,GO:0034260,GO:0034506,GO:0045184,GO:0048041,GO:0048365,GO:0051301,GO:0051895,GO:0051987,GO:0072356,GO:0090630,GO:1900025,GO:1900027,GO:1990023 RNA binding|nucleolus|cytosol|microtubule|plasma membrane|sister chromatid cohesion|integrin-mediated signaling pathway|microtubule binding|regulation of fibroblast migration|positive regulation of G2/M transition of mitotic cell cycle|protein kinase binding|protein domain specific binding|regulation of cell migration|midbody|small GTPase binding|early endosome membrane|negative regulation of GTPase activity|chromosome, centromeric core domain|establishment of protein localization|focal adhesion assembly|Rac GTPase binding|cell division|negative regulation of focal adhesion assembly|positive regulation of attachment of spindle microtubules to kinetochore|chromosome passenger complex localization to kinetochore|activation of GTPase activity|negative regulation of substrate adhesion-dependent cell spreading|regulation of ruffle assembly|mitotic spindle midzone RCCD1 20.7411762386364 19.1892199154911 22.2931325617817 1.16175293523969 0.216303289910305 0.741124285826323 1 0.412941 0.214468 0.429038 0.380175 GeneID:91433,Genbank:NM_033544.2,HGNC:HGNC:30457 RCC1 domain containing 1 GO:0005694,GO:0005829,GO:0005886,GO:0016569 chromosome|cytosol|plasma membrane|covalent chromatin modification RCE1 345.91384303382 358.870243051715 332.957443015925 0.927793400156457 -0.108124511251259 0.559267381977593 1 13.6726 15.8291 15.6421 13.2354 GeneID:9986,Genbank:NM_005133.2,HGNC:HGNC:13721,MIM:605385 Ras converting CAAX endopeptidase 1 GO:0004175,GO:0004197,GO:0004222,GO:0005789,GO:0005829,GO:0005887,GO:0006508,GO:0016020,GO:0016579,GO:0030176,GO:0071586 endopeptidase activity|cysteine-type endopeptidase activity|metalloendopeptidase activity|endoplasmic reticulum membrane|cytosol|integral component of plasma membrane|proteolysis|membrane|protein deubiquitination|integral component of endoplasmic reticulum membrane|CAAX-box protein processing hsa00900 Terpenoid backbone biosynthesis RCHY1 317.843381168076 324.065364857635 311.621397478517 0.961600440131623 -0.0564905385059374 0.797064080962005 1 2.96982 2.63808 2.75752 2.4879 GeneID:25898,Genbank:NM_001278538.1,HGNC:HGNC:17479,MIM:607680 ring finger and CHY zinc finger domain containing 1 hsa04115,hsa04120,hsa05162 p53 signaling pathway|Ubiquitin mediated proteolysis|Measles RCL1 501.179193360127 579.282636069524 423.075750650731 0.730344264280614 -0.45335142364256 0.00916446623128985 0.375391537494471 6.90627 7.57578 5.67496 5.40647 GeneID:10171,Genbank:NM_005772.4,HGNC:HGNC:17687,MIM:611405 RNA terminal phosphate cyclase like 1 GO:0000447,GO:0000479,GO:0000480,GO:0004521,GO:0005654,GO:0005730,GO:0006364 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endoribonuclease activity|nucleoplasm|nucleolus|rRNA processing hsa03008 Ribosome biogenesis in eukaryotes RCN1 8611.82577528761 8823.18255990294 8400.46899067227 0.952090578840373 -0.0708292614513144 0.599052924080442 1 126.902 123.549 129.589 111.003 GeneID:5954,Genbank:NM_002901.2,HGNC:HGNC:9934,MIM:602735 reticulocalbin 1 GO:0001701,GO:0005509,GO:0005783,GO:0005788,GO:0043010,GO:0043687,GO:0044267 in utero embryonic development|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum lumen|camera-type eye development|post-translational protein modification|cellular protein metabolic process RCN2 3175.18514784596 3460.16335103025 2890.20694466168 0.835280491541283 -0.25966735142772 0.0595759786801102 0.879410748501007 73.6937 71.1021 59.0891 62.1485 GeneID:5955,Genbank:NM_001271837.1,HGNC:HGNC:9935,MIM:602584 reticulocalbin 2 GO:0005509,GO:0005730,GO:0005783,GO:0005788 calcium ion binding|nucleolus|endoplasmic reticulum|endoplasmic reticulum lumen RCN3 2.3149458107534 2.69048838321152 1.93940323829528 0.720836874969257 -0.472255279664697 0.966042241730723 1 0.070733 0 0.064839 0.0201564 GeneID:57333,Genbank:XM_024451620.1,HGNC:HGNC:21145 reticulocalbin 3 GO:0005509,GO:0005788 calcium ion binding|endoplasmic reticulum lumen RCOR1 732.414833768286 775.123815404563 689.70585213201 0.889800878808025 -0.168445571501384 0.404177038913807 1 6.45752 5.68873 6.29441 4.66259 GeneID:23186,Genbank:NM_015156.3,HGNC:HGNC:17441,MIM:607675 REST corepressor 1 GO:0001078,GO:0003714,GO:0004407,GO:0005634,GO:0005654,GO:0005667,GO:0006351,GO:0007596,GO:0008134,GO:0016032,GO:0017053,GO:0044212,GO:0045892,GO:0070933,GO:1990391 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcription corepressor activity|histone deacetylase activity|nucleus|nucleoplasm|transcription factor complex|transcription, DNA-templated|blood coagulation|transcription factor binding|viral process|transcriptional repressor complex|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|histone H4 deacetylation|DNA repair complex hsa05016 Huntington disease RCOR2 19.7985437738033 19.7371262472414 19.8599613003653 1.00622355309406 0.00895086489537019 1 1 0.156276 0.350045 0.125602 0.335691 GeneID:283248,Genbank:NM_173587.3,HGNC:HGNC:27455,MIM:616019 REST corepressor 2 GO:0000122,GO:0003700,GO:0003714,GO:0005634,GO:0005667,GO:0006351,GO:0008134,GO:0017053,GO:0019899,GO:0044212 negative regulation of transcription from RNA polymerase II promoter|DNA binding transcription factor activity|transcription corepressor activity|nucleus|transcription factor complex|transcription, DNA-templated|transcription factor binding|transcriptional repressor complex|enzyme binding|transcription regulatory region DNA binding RCOR3 322.187156164025 322.05705297512 322.31725935293 1.00080795118568 0.0011651565374215 0.987901110916401 1 1.71682 1.54913 1.9634 1.41272 GeneID:55758,Genbank:NM_001350069.1,HGNC:HGNC:25594 REST corepressor 3 GO:0000122,GO:0003700,GO:0003714,GO:0005634,GO:0005667,GO:0006351,GO:0008134,GO:0017053,GO:0044212 negative regulation of transcription from RNA polymerase II promoter|DNA binding transcription factor activity|transcription corepressor activity|nucleus|transcription factor complex|transcription, DNA-templated|transcription factor binding|transcriptional repressor complex|transcription regulatory region DNA binding RCSD1 2.0028737971175 3.03648096111406 0.969266633120943 0.319207215699231 -1.64743483074616 0.553604484816263 1 0.00746027 0.0276622 0.00709317 0.00661866 GeneID:92241,Genbank:NM_001322923.1,HGNC:HGNC:28310,MIM:610579 RCSD domain containing 1 GO:0003009,GO:0005884,GO:0051015,GO:0071474 skeletal muscle contraction|actin filament|actin filament binding|cellular hyperosmotic response RCVRN 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0263684 GeneID:5957,Genbank:NM_002903.2,HGNC:HGNC:9937,MIM:179618 recoverin GO:0005509,GO:0007165,GO:0007601,GO:0007602,GO:0008048,GO:0030425,GO:0051924 calcium ion binding|signal transduction|visual perception|phototransduction|calcium sensitive guanylate cyclase activator activity|dendrite|regulation of calcium ion transport hsa04744 Phototransduction RDH10 279.31403387366 306.125845084807 252.502222662513 0.824831443397279 -0.277828764159195 0.169793277152597 1 3.83564 4.12191 3.48932 3.08782 GeneID:157506,Genbank:NM_172037.4,HGNC:HGNC:19975,MIM:607599 retinol dehydrogenase 10 GO:0001523,GO:0001656,GO:0001701,GO:0002138,GO:0004745,GO:0005737,GO:0005789,GO:0007601,GO:0008406,GO:0014032,GO:0016021,GO:0031076,GO:0031090,GO:0035115,GO:0042572,GO:0042574,GO:0043583,GO:0043584,GO:0044297,GO:0048703,GO:0052650,GO:0060431,GO:0060449 retinoid metabolic process|metanephros development|in utero embryonic development|retinoic acid biosynthetic process|retinol dehydrogenase activity|cytoplasm|endoplasmic reticulum membrane|visual perception|gonad development|neural crest cell development|integral component of membrane|embryonic camera-type eye development|organelle membrane|embryonic forelimb morphogenesis|retinol metabolic process|retinal metabolic process|ear development|nose development|cell body|embryonic viscerocranium morphogenesis|NADP-retinol dehydrogenase activity|primary lung bud formation|bud elongation involved in lung branching hsa00830 Retinol metabolism RDH11 1882.35490207491 1866.31019110288 1898.39961304695 1.01719404528628 0.0245949215438205 0.854417914463624 1 27.575 27.0321 30.8071 25.3969 GeneID:51109,Genbank:NM_001252650.1,HGNC:HGNC:17964,MIM:607849 retinol dehydrogenase 11 GO:0001523,GO:0001917,GO:0004745,GO:0005622,GO:0005789,GO:0016021,GO:0016062,GO:0016616,GO:0042572,GO:0042574,GO:0052650 retinoid metabolic process|photoreceptor inner segment|retinol dehydrogenase activity|intracellular|endoplasmic reticulum membrane|integral component of membrane|adaptation of rhodopsin mediated signaling|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|retinol metabolic process|retinal metabolic process|NADP-retinol dehydrogenase activity hsa00830 Retinol metabolism RDH12 1.56082866984508 2.15239070656922 0.969266633120943 0.450320952493749 -1.15097449005773 0.809702902204566 1 0.108977 0 0 0.0238306 GeneID:145226,Genbank:NM_152443.2,HGNC:HGNC:19977,MIM:608830 retinol dehydrogenase 12 GO:0001523,GO:0004745,GO:0005622,GO:0007601,GO:0042572,GO:0045494,GO:0050896,GO:0052650,GO:0060342 retinoid metabolic process|retinol dehydrogenase activity|intracellular|visual perception|retinol metabolic process|photoreceptor cell maintenance|response to stimulus|NADP-retinol dehydrogenase activity|photoreceptor inner segment membrane hsa00830 Retinol metabolism RDH13 388.193140143759 417.29256708741 359.093713200108 0.860532253681118 -0.216698827835423 0.250873230344297 1 1.99912 1.80739 1.56301 1.76489 GeneID:112724,Genbank:XM_011526408.3,HGNC:HGNC:19978 retinol dehydrogenase 13 GO:0005743,GO:0009644,GO:0010842,GO:0042462,GO:0052650 mitochondrial inner membrane|response to high light intensity|retina layer formation|eye photoreceptor cell development|NADP-retinol dehydrogenase activity RDH14 28.9738882228391 27.4145725442885 30.5332039013898 1.11375816099497 0.15543600304581 0.779206468320959 1 9.95039 8.11247 9.75929 7.94584 GeneID:57665,Genbank:NM_020905.3,HGNC:HGNC:19979,MIM:616796 retinol dehydrogenase 14 GO:0001649,GO:0005634,GO:0005739,GO:0005765,GO:0005783,GO:0005789,GO:0016020,GO:0016491,GO:0052650 osteoblast differentiation|nucleus|mitochondrion|lysosomal membrane|endoplasmic reticulum|endoplasmic reticulum membrane|membrane|oxidoreductase activity|NADP-retinol dehydrogenase activity RDH16 2.72503816560136 2.05633815719933 3.3937381740034 1.65037941941687 0.722797735734548 0.792472188633315 1 0.014605 0.0264659 0.0690314 0.0257001 GeneID:8608,Genbank:NM_001320108.1,HGNC:HGNC:29674 retinol dehydrogenase 16 GO:0004745,GO:0005789,GO:0006629,GO:0009055,GO:0016021,GO:0031090,GO:0043231 retinol dehydrogenase activity|endoplasmic reticulum membrane|lipid metabolic process|electron transfer activity|integral component of membrane|organelle membrane|intracellular membrane-bounded organelle hsa00830 Retinol metabolism RDH5 40.0296233068068 29.1827530533781 50.8764935602354 1.74337539255386 0.801883251428075 0.0772700187178074 0.94157495521624 0.659227 0.610271 0.953112 1.29197 GeneID:5959,Genbank:NM_001199771.1,HGNC:HGNC:9940,MIM:601617 retinol dehydrogenase 5 hsa00830 Retinol metabolism RDH8 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0 0 0 GeneID:50700,Genbank:NM_015725.2,HGNC:HGNC:14423,MIM:608575 retinol dehydrogenase 8 GO:0004303,GO:0004745,GO:0005737,GO:0005887,GO:0006694,GO:0006703,GO:0007601,GO:0050896,GO:0052650 estradiol 17-beta-dehydrogenase activity|retinol dehydrogenase activity|cytoplasm|integral component of plasma membrane|steroid biosynthetic process|estrogen biosynthetic process|visual perception|response to stimulus|NADP-retinol dehydrogenase activity hsa00830 Retinol metabolism RDM1 38.5534501638897 29.1347267786932 47.9721735490862 1.646563357655 0.719458026063879 0.121154329032201 1 0.168654 0.235454 0.36804 0.359748 GeneID:201299,Genbank:NM_001163120.1,HGNC:HGNC:19950,MIM:612896 RAD52 motif containing 1 GO:0003677,GO:0003723,GO:0005730,GO:0005829,GO:0015030,GO:0016605 DNA binding|RNA binding|nucleolus|cytosol|Cajal body|PML body RDX 2279.6291415902 2522.69163140885 2036.56665177154 0.807299087377625 -0.308824834101439 0.131089310910282 1 17.4765 15.0476 14.5979 11.6884 GeneID:5962,Genbank:NM_001260493.1,HGNC:HGNC:9944,MIM:179410 radixin GO:0001726,GO:0003723,GO:0003779,GO:0005615,GO:0005886,GO:0005902,GO:0005913,GO:0005925,GO:0008360,GO:0008361,GO:0010628,GO:0010737,GO:0016324,GO:0019904,GO:0030027,GO:0030033,GO:0030175,GO:0030315,GO:0030335,GO:0030496,GO:0030864,GO:0032154,GO:0032231,GO:0032420,GO:0032487,GO:0034111,GO:0034260,GO:0036120,GO:0042803,GO:0043087,GO:0043209,GO:0045176,GO:0045184,GO:0045296,GO:0045792,GO:0051016,GO:0051018,GO:0051117,GO:0051286,GO:0061028,GO:0070062,GO:0071944,GO:0072659,GO:0097067,GO:1900027,GO:1900087,GO:1902115,GO:1902966,GO:1903364,GO:1903392,GO:2000643 ruffle|RNA binding|actin binding|extracellular space|plasma membrane|microvillus|cell-cell adherens junction|focal adhesion|regulation of cell shape|regulation of cell size|positive regulation of gene expression|protein kinase A signaling|apical plasma membrane|protein domain specific binding|lamellipodium|microvillus assembly|filopodium|T-tubule|positive regulation of cell migration|midbody|cortical actin cytoskeleton|cleavage furrow|regulation of actin filament bundle assembly|stereocilium|regulation of Rap protein signal transduction|negative regulation of homotypic cell-cell adhesion|negative regulation of GTPase activity|cellular response to platelet-derived growth factor stimulus|protein homodimerization activity|regulation of GTPase activity|myelin sheath|apical protein localization|establishment of protein localization|cadherin binding|negative regulation of cell size|barbed-end actin filament capping|protein kinase A binding|ATPase binding|cell tip|establishment of endothelial barrier|extracellular exosome|cell periphery|protein localization to plasma membrane|cellular response to thyroid hormone stimulus|regulation of ruffle assembly|positive regulation of G1/S transition of mitotic cell cycle|regulation of organelle assembly|positive regulation of protein localization to early endosome|positive regulation of cellular protein catabolic process|negative regulation of adherens junction organization|positive regulation of early endosome to late endosome transport hsa04530,hsa04810,hsa05205,hsa05206 Tight junction|Regulation of actin cytoskeleton|Proteoglycans in cancer|MicroRNAs in cancer REC8 47.035668982008 42.2029584972713 51.8683794667447 1.229022355627 0.297511158232032 0.520092837626226 1 0.29403 0.286631 0.589144 0.255942 GeneID:9985,Genbank:XM_017021841.2,HGNC:HGNC:16879,MIM:608193 REC8 meiotic recombination protein GO:0000724,GO:0000778,GO:0000798,GO:0000800,GO:0001556,GO:0001673,GO:0003682,GO:0005634,GO:0006302,GO:0007062,GO:0007130,GO:0007131,GO:0007141,GO:0007283,GO:0007286,GO:0009566,GO:0030893,GO:0034991,GO:0051321,GO:0072520 double-strand break repair via homologous recombination|condensed nuclear chromosome kinetochore|nuclear cohesin complex|lateral element|oocyte maturation|male germ cell nucleus|chromatin binding|nucleus|double-strand break repair|sister chromatid cohesion|synaptonemal complex assembly|reciprocal meiotic recombination|male meiosis I|spermatogenesis|spermatid development|fertilization|meiotic cohesin complex|nuclear meiotic cohesin complex|meiotic cell cycle|seminiferous tubule development hsa04114 Oocyte meiosis RECK 448.039173746976 468.134514376282 427.943833117671 0.914147152101872 -0.129501677394078 0.470121047914921 1 2.07194 2.22563 2.02117 1.8336 GeneID:8434,Genbank:XM_017015208.1,HGNC:HGNC:11345,MIM:605227 reversion inducing cysteine rich protein with kazal motifs GO:0001955,GO:0004866,GO:0004867,GO:0005576,GO:0005886,GO:0006501,GO:0007566,GO:0008191,GO:0016020,GO:0030198,GO:0030336,GO:0031225,GO:0035115,GO:1904684 blood vessel maturation|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|plasma membrane|C-terminal protein lipidation|embryo implantation|metalloendopeptidase inhibitor activity|membrane|extracellular matrix organization|negative regulation of cell migration|anchored component of membrane|embryonic forelimb morphogenesis|negative regulation of metalloendopeptidase activity hsa05206 MicroRNAs in cancer RECQL 439.316451921767 443.379987249026 435.252916594507 0.981670190607962 -0.0266896877552275 0.969443760629624 1 5.14669 3.80963 5.04184 3.84816 GeneID:5965,Genbank:NM_032941.2,HGNC:HGNC:9948,MIM:600537 RecQ like helicase RECQL4 1503.36091999228 1470.01527606134 1536.70656392322 1.04536775157914 0.0640105595754834 0.675815124862069 1 12.3589 11.8955 12.4485 13.0903 GeneID:9401,Genbank:NM_004260.3,HGNC:HGNC:9949,MIM:603780 RecQ like helicase 4 RECQL5 425.037530782368 398.43073944046 451.644322124277 1.13355792466853 0.180858114498949 0.332222774433151 1 1.58606 1.77394 1.78938 2.12883 GeneID:9400,Genbank:XM_005257818.4,HGNC:HGNC:9950,MIM:603781 RecQ like helicase 5 REELD1 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0 0.00961792 0 0.00923754 GeneID:345051,Genbank:NM_001354631.1,HGNC:HGNC:53638 reeler domain containing 1 GO:0000293,GO:0016021,GO:0046872 ferric-chelate reductase activity|integral component of membrane|metal ion binding REEP1 71.0858933555943 80.149161856089 62.0226248550996 0.773839968114247 -0.369892850325536 0.291126350840263 1 0.69401 0.631068 0.438459 0.535562 GeneID:65055,Genbank:NM_001164730.1,HGNC:HGNC:25786,MIM:609139 receptor accessory protein 1 GO:0005737,GO:0005783,GO:0005789,GO:0008017,GO:0016020,GO:0016021,GO:0031849,GO:0031966,GO:0032386,GO:0051205,GO:0071782,GO:0071786 cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|microtubule binding|membrane|integral component of membrane|olfactory receptor binding|mitochondrial membrane|regulation of intracellular transport|protein insertion into membrane|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network organization REEP2 1071.20265838254 910.526584167995 1231.87873259709 1.35293000118468 0.436087198105173 0.00406730204673841 0.249352958245434 16.5879 16.8004 22.4539 23.4055 GeneID:51308,Genbank:NM_001271803.1,HGNC:HGNC:17975,MIM:609347 receptor accessory protein 2 GO:0005783,GO:0005789,GO:0005881,GO:0005887,GO:0031883,GO:0032386,GO:0032596,GO:0050913,GO:0050916,GO:0070062,GO:0071786 endoplasmic reticulum|endoplasmic reticulum membrane|cytoplasmic microtubule|integral component of plasma membrane|taste receptor binding|regulation of intracellular transport|protein transport into membrane raft|sensory perception of bitter taste|sensory perception of sweet taste|extracellular exosome|endoplasmic reticulum tubular network organization REEP3 1047.16056500743 1057.58215437136 1036.7389756435 0.980291669406757 -0.028717031985047 0.898561900919213 1 2.90628 2.74418 3.26076 2.38754 GeneID:221035,Genbank:XM_011539501.2,HGNC:HGNC:23711,MIM:609348 receptor accessory protein 3 GO:0005789,GO:0005874,GO:0006998,GO:0007084,GO:0016021,GO:0051301 endoplasmic reticulum membrane|microtubule|nuclear envelope organization|mitotic nuclear envelope reassembly|integral component of membrane|cell division REEP4 1366.66946771048 1432.15633359764 1301.18260182332 0.90854788077129 -0.138365547922673 0.326726177878781 1 41.0353 43.3162 38.2268 40.3452 GeneID:80346,Genbank:NM_001316965.1,HGNC:HGNC:26176,MIM:609349 receptor accessory protein 4 GO:0005783,GO:0005789,GO:0005874,GO:0006998,GO:0007084,GO:0008017,GO:0016021,GO:0051301 endoplasmic reticulum|endoplasmic reticulum membrane|microtubule|nuclear envelope organization|mitotic nuclear envelope reassembly|microtubule binding|integral component of membrane|cell division REEP5 2682.12755366959 2528.34623351744 2835.90887382173 1.12164577628927 0.165617134523476 0.225431342233923 1 13.5407 13.6639 15.8075 15.7994 GeneID:7905,Genbank:NM_005669.4,HGNC:HGNC:30077,MIM:125265 receptor accessory protein 5 GO:0016021,GO:0070062,GO:0071782 integral component of membrane|extracellular exosome|endoplasmic reticulum tubular network REEP6 127.280565821571 142.147081530395 112.414050112748 0.790829110963569 -0.338562116245918 0.238302062716133 1 4.15184 4.00336 2.67822 4.01458 GeneID:92840,Genbank:NM_001329556.2,HGNC:HGNC:30078,MIM:609346 receptor accessory protein 6 GO:0001917,GO:0005634,GO:0005783,GO:0005789,GO:0016021,GO:0032386,GO:0044317,GO:0045177,GO:0050908 photoreceptor inner segment|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|regulation of intracellular transport|rod spherule|apical part of cell|detection of light stimulus involved in visual perception REL 32.3911186825369 31.3351437599474 33.4470936051264 1.06739876036179 0.0940992409461453 0.878756424202858 1 0.15858 0.157474 0.219658 0.131436 GeneID:5966,Genbank:NM_002908.3,HGNC:HGNC:9954,MIM:164910 REL proto-oncogene, NF-kB subunit hsa04014,hsa05202,hsa05203 Ras signaling pathway|Transcriptional misregulation in cancer|Viral carcinogenesis RELA 1681.19865483586 1721.99313555741 1640.40417411431 0.952619461855932 -0.0700280718664809 0.619216603681824 1 25.4992 24.6018 23.2179 24.455 GeneID:5970,Genbank:NM_001145138.1,HGNC:HGNC:9955,MIM:164014 RELA proto-oncogene, NF-kB subunit hsa01523,hsa04010,hsa04014,hsa04024,hsa04062,hsa04064,hsa04066,hsa04071,hsa04137,hsa04151,hsa04210,hsa04211,hsa04218,hsa04380,hsa04620,hsa04621,hsa04622,hsa04623,hsa04625,hsa04657,hsa04658,hsa04659,hsa04660,hsa04662,hsa04668,hsa04722,hsa04917,hsa04920,hsa04926,hsa04931,hsa04932,hsa04933,hsa05030,hsa05120,hsa05131,hsa05132,hsa05133,hsa05134,hsa05140,hsa05142,hsa05145,hsa05146,hsa05152,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05202,hsa05203,hsa05212,hsa05215,hsa05220,hsa05221,hsa05222,hsa05321,hsa05418 Antifolate resistance|MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|NF-kappa B signaling pathway|HIF-1 signaling pathway|Sphingolipid signaling pathway|Mitophagy - animal|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Cellular senescence|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|C-type lectin receptor signaling pathway|IL-17 signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|B cell receptor signaling pathway|TNF signaling pathway|Neurotrophin signaling pathway|Prolactin signaling pathway|Adipocytokine signaling pathway|Relaxin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Cocaine addiction|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Salmonella infection|Pertussis|Legionellosis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Pancreatic cancer|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Small cell lung cancer|Inflammatory bowel disease (IBD)|Fluid shear stress and atherosclerosis RELB 381.082991432352 407.895983556813 354.269999307892 0.868530246899448 -0.203352002667886 0.260901128768718 1 7.19841 8.32933 7.13881 6.47776 GeneID:5971,Genbank:NM_006509.3,HGNC:HGNC:9956,MIM:604758 RELB proto-oncogene, NF-kB subunit hsa04010,hsa04064,hsa04380,hsa04625,hsa05166,hsa05169 MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|C-type lectin receptor signaling pathway|Human T-cell leukemia virus 1 infection|Epstein-Barr virus infection RELL1 232.725750854195 212.946669129717 252.504832578673 1.18576558915256 0.245818835522854 0.264543013424597 1 1.96921 2.22143 2.61592 2.2679 GeneID:768211,Genbank:NM_001085399.1,HGNC:HGNC:27379,MIM:611212 RELT like 1 GO:0005886,GO:0015630,GO:0016021 plasma membrane|microtubule cytoskeleton|integral component of membrane RELL2 691.157513660575 677.209655565879 705.10537175527 1.04119214184281 0.0582363284881737 0.753931619524807 1 7.49284 8.38807 8.21647 8.06645 GeneID:285613,Genbank:NM_173828.4,HGNC:HGNC:26902,MIM:611213 RELT like 2 GO:0005518,GO:0005604,GO:0005886,GO:0010811,GO:0016021 collagen binding|basement membrane|plasma membrane|positive regulation of cell-substrate adhesion|integral component of membrane RELT 413.372045553798 384.756766460339 441.987324647257 1.14874477377857 0.20005829797926 0.279659839324314 1 4.57141 4.35921 5.3615 4.94932 GeneID:84957,Genbank:NM_152222.1,HGNC:HGNC:13764,MIM:611211 RELT, TNF receptor GO:0005031,GO:0005634,GO:0005737,GO:0005887,GO:0006954,GO:0006955,GO:0007275,GO:0032496,GO:0042127,GO:0042981,GO:0070062,GO:0097190 tumor necrosis factor-activated receptor activity|nucleus|cytoplasm|integral component of plasma membrane|inflammatory response|immune response|multicellular organism development|response to lipopolysaccharide|regulation of cell proliferation|regulation of apoptotic process|extracellular exosome|apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction REM2 2.80708377636916 4.16070258908361 1.45346496365472 0.349331617085094 -1.5173308717148 0.488643755368115 1 0.0421281 0.0373458 0.0130611 0.0245107 GeneID:161253,Genbank:XM_005267383.3,HGNC:HGNC:20248,MIM:616955 RRAD and GEM like GTPase 2 GO:0003924,GO:0005525,GO:0005886,GO:0007165,GO:1901842 GTPase activity|GTP binding|plasma membrane|signal transduction|negative regulation of high voltage-gated calcium channel activity RENBP 6.69078498585482 5.6309167949557 7.75065317675395 1.37644604937107 0.460948063743735 0.740513239885764 1 0.175136 0.120443 0.0644943 0.329608 GeneID:5973,Genbank:XM_017029698.1,HGNC:HGNC:9959,MIM:312420 renin binding protein GO:0004866,GO:0005524,GO:0005829,GO:0006044,GO:0006048,GO:0006051,GO:0008217,GO:0019262,GO:0042803,GO:0050121,GO:0070062 endopeptidase inhibitor activity|ATP binding|cytosol|N-acetylglucosamine metabolic process|UDP-N-acetylglucosamine biosynthetic process|N-acetylmannosamine metabolic process|regulation of blood pressure|N-acetylneuraminate catabolic process|protein homodimerization activity|N-acylglucosamine 2-epimerase activity|extracellular exosome hsa00520 Amino sugar and nucleotide sugar metabolism REP15 6.61625693033712 9.83964565872424 3.39286820195 0.344816095988349 -1.53610097399698 0.204014058391806 1 0.400929 0.335935 0.0850758 0.0394881 GeneID:387849,Genbank:NM_001029874.2,HGNC:HGNC:33748,MIM:610848 RAB15 effector protein GO:0001881,GO:0010008,GO:0031901,GO:0033572,GO:0048471,GO:0055037 receptor recycling|endosome membrane|early endosome membrane|transferrin transport|perinuclear region of cytoplasm|recycling endosome REPIN1 5520.57621859242 5535.84497697768 5505.30746020716 0.994483675591077 -0.00798040541415858 0.932921290592577 1 52.2231 55.0771 54.5222 53.798 GeneID:29803,Genbank:XM_006715949.3,HGNC:HGNC:17922 replication initiator 1 GO:0003677,GO:0003723,GO:0005634,GO:0005664,GO:0006260,GO:0046872 DNA binding|RNA binding|nucleus|nuclear origin of replication recognition complex|DNA replication|metal ion binding REPS1 974.42893387601 985.909302173457 962.948565578562 0.976711106646141 -0.03399619251109 0.827686544252216 1 8.10715 7.91648 8.12507 7.88841 GeneID:85021,Genbank:NM_001286612.1,HGNC:HGNC:15578,MIM:614825 RALBP1 associated Eps domain containing 1 GO:0005509,GO:0005829,GO:0005886,GO:0005905,GO:0006898,GO:0017124,GO:0061024 calcium ion binding|cytosol|plasma membrane|clathrin-coated pit|receptor-mediated endocytosis|SH3 domain binding|membrane organization REPS2 96.4481242760862 91.6031005447402 101.293148007432 1.10578296373232 0.145068250063197 0.632286525109457 1 0.345417 0.324232 0.440087 0.368451 GeneID:9185,Genbank:NM_004726.2,HGNC:HGNC:9963,MIM:300317 RALBP1 associated Eps domain containing 2 RER1 4958.57088052013 4775.40063531905 5141.7411257212 1.07671408503251 0.106635201722654 0.431684340791478 1 42.8354 44.4862 47.1548 48.6676 GeneID:11079,Genbank:XM_011540543.2,HGNC:HGNC:30309 retention in endoplasmic reticulum sorting receptor 1 GO:0005793,GO:0005794,GO:0005886,GO:0006890,GO:0009986,GO:0030173,GO:0033130,GO:0071340,GO:1903078 endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|plasma membrane|retrograde vesicle-mediated transport, Golgi to ER|cell surface|integral component of Golgi membrane|acetylcholine receptor binding|skeletal muscle acetylcholine-gated channel clustering|positive regulation of protein localization to plasma membrane RERE 2922.5042776646 2862.39939086128 2982.60916446793 1.04199615678736 0.059349956508894 0.686282618156025 1 10.0051 10.954 12.0962 10.104 GeneID:473,Genbank:XM_017001358.1,HGNC:HGNC:9965,MIM:605226 arginine-glutamic acid dipeptide repeats GO:0000118,GO:0001105,GO:0001106,GO:0003682,GO:0003700,GO:0005634,GO:0006338,GO:0006607,GO:0008267,GO:0008270,GO:0021691,GO:0021930,GO:0021942,GO:0043565,GO:0048755,GO:0048813 histone deacetylase complex|RNA polymerase II transcription coactivator activity|RNA polymerase II transcription corepressor activity|chromatin binding|DNA binding transcription factor activity|nucleus|chromatin remodeling|NLS-bearing protein import into nucleus|poly-glutamine tract binding|zinc ion binding|cerebellar Purkinje cell layer maturation|cerebellar granule cell precursor proliferation|radial glia guided migration of Purkinje cell|sequence-specific DNA binding|branching morphogenesis of a nerve|dendrite morphogenesis RERG 8.54521898386532 7.8793600508948 9.21107791683585 1.16901345506985 0.225291535045643 0.851614059253426 1 0.163889 0.0625331 0.172323 0.0876211 GeneID:85004,Genbank:NM_001190726.1,HGNC:HGNC:15980,MIM:612664 RAS like estrogen regulated growth inhibitor GO:0003924,GO:0005525,GO:0005634,GO:0005829,GO:0007264,GO:0008285,GO:0009725,GO:0016020,GO:0019003,GO:0030308,GO:0030331 GTPase activity|GTP binding|nucleus|cytosol|small GTPase mediated signal transduction|negative regulation of cell proliferation|response to hormone|membrane|GDP binding|negative regulation of cell growth|estrogen receptor binding RERGL 2.22389636075371 3.47852608838648 0.969266633120943 0.278642910385801 -1.84351064802568 0.454998762117736 1 0.0382168 0.222189 0.0364342 0.033843 GeneID:79785,Genbank:NM_001286201.1,HGNC:HGNC:26213 RERG like GO:0003924,GO:0005525,GO:0007165,GO:0016020 GTPase activity|GTP binding|signal transduction|membrane REST 359.37492254208 388.656703364927 330.093141719232 0.849318019890918 -0.235623235089185 0.538937362989664 1 2.26146 1.73849 2.1005 1.33232 GeneID:5978,Genbank:NM_005612.4,HGNC:HGNC:9966,MIM:600571 RE1 silencing transcription factor hsa04550,hsa05016 Signaling pathways regulating pluripotency of stem cells|Huntington disease RET 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00621032 GeneID:5979,Genbank:NM_020975.5,HGNC:HGNC:9967,MIM:164761 ret proto-oncogene hsa05200,hsa05216,hsa05230 Pathways in cancer|Thyroid cancer|Central carbon metabolism in cancer RETREG1 73.5713435002728 81.2351658644816 65.9075211360639 0.81131761638811 -0.301661280465604 0.371283887941546 1 0.64118 0.821112 0.609243 0.586003 GeneID:54463,Genbank:XM_011514053.3,HGNC:HGNC:25964,MIM:613114 reticulophagy regulator 1 GO:0005730,GO:0005783,GO:0005794,GO:0005801,GO:0016604,GO:0019233,GO:0030176,GO:0043524,GO:0061709 nucleolus|endoplasmic reticulum|Golgi apparatus|cis-Golgi network|nuclear body|sensory perception of pain|integral component of endoplasmic reticulum membrane|negative regulation of neuron apoptotic process|reticulophagy RETREG2 2629.15471346815 2376.19987819747 2882.10954873883 1.21290703496085 0.278468977217907 0.0465953942318762 0.79332376136203 19.7573 22.4078 26.8587 25.2787 GeneID:79137,Genbank:NM_024293.5,HGNC:HGNC:28450 reticulophagy regulator family member 2 GO:0016021 integral component of membrane RETREG3 1236.65291224826 1227.81821029334 1245.48761420318 1.0143908957871 0.0206137023824092 0.903358742229288 1 13.6981 14.3859 14.3382 13.9922 GeneID:162427,Genbank:NM_178126.3,HGNC:HGNC:27258,MIM:616498 reticulophagy regulator family member 3 GO:0010976,GO:0016021 positive regulation of neuron projection development|integral component of membrane RETSAT 995.503701249469 942.293964400107 1048.71343809883 1.11293659698486 0.154371405958415 0.315576098167189 1 11.0911 11.1401 12.497 12.9261 GeneID:54884,Genbank:NM_017750.3,HGNC:HGNC:25991,MIM:617597 retinol saturase GO:0005640,GO:0005789,GO:0016020,GO:0016491,GO:0031965,GO:0042572,GO:0051786,GO:0055114 nuclear outer membrane|endoplasmic reticulum membrane|membrane|oxidoreductase activity|nuclear membrane|retinol metabolic process|all-trans-retinol 13,14-reductase activity|oxidation-reduction process hsa00830 Retinol metabolism REV1 426.184468650162 447.185905605954 405.18303169437 0.906072903047629 -0.142300960031 0.456225132708971 1 1.82458 1.57218 1.85591 1.43735 GeneID:51455,Genbank:NM_001037872.2,HGNC:HGNC:14060,MIM:606134 REV1, DNA directed polymerase GO:0003684,GO:0005654,GO:0006260,GO:0009411,GO:0017125,GO:0019985,GO:0042276,GO:0046872 damaged DNA binding|nucleoplasm|DNA replication|response to UV|deoxycytidyl transferase activity|translesion synthesis|error-prone translesion synthesis|metal ion binding hsa03460 Fanconi anemia pathway REV3L 162.709544550499 148.478775135409 176.940313965589 1.19168759173979 0.253006073953801 0.634393821860899 1 0.329452 0.261875 0.472539 0.24446 GeneID:5980,Genbank:NM_002912.4,HGNC:HGNC:9968,MIM:602776 REV3 like, DNA directed polymerase zeta catalytic subunit hsa01524,hsa03460 Platinum drug resistance|Fanconi anemia pathway REX1BD 606.075569112483 568.098254719621 644.052883505345 1.13369981012036 0.181038682799463 0.292221387177652 1 24.4013 24.1296 28.4116 27.8165 GeneID:55049,Genbank:NM_001100418.1,HGNC:HGNC:26098 required for excision 1-B domain containing REXO1 1293.52394267121 1277.51733564488 1309.53054969754 1.02505892731115 0.0357068479706526 0.837998418058342 1 7.53368 8.11471 8.81739 7.62739 GeneID:57455,Genbank:NM_020695.3,HGNC:HGNC:24616,MIM:609614 RNA exonuclease 1 homolog GO:0003676,GO:0004527,GO:0005654,GO:0016604 nucleic acid binding|exonuclease activity|nucleoplasm|nuclear body hsa03008 Ribosome biogenesis in eukaryotes REXO2 1117.34727599741 1144.76683764509 1089.92771434973 0.95209581419377 -0.0708213283850874 0.632010619901909 1 38.541 41.5538 40.2196 38.5304 GeneID:25996,Genbank:NM_015523.3,HGNC:HGNC:17851,MIM:607149 RNA exonuclease 2 GO:0000175,GO:0003676,GO:0005634,GO:0005730,GO:0005739,GO:0005758,GO:0005759,GO:0005925,GO:0006139,GO:0008408,GO:0009117 3'-5'-exoribonuclease activity|nucleic acid binding|nucleus|nucleolus|mitochondrion|mitochondrial intermembrane space|mitochondrial matrix|focal adhesion|nucleobase-containing compound metabolic process|3'-5' exonuclease activity|nucleotide metabolic process hsa03008 Ribosome biogenesis in eukaryotes REXO4 1014.77706480813 1066.14572492466 963.408404691601 0.903636700095269 -0.146185229678454 0.329766587639879 1 11.8562 12.5598 11.0672 11.4537 GeneID:57109,Genbank:NM_001279351.1,HGNC:HGNC:12820,MIM:602930 REX4 homolog, 3'-5' exonuclease GO:0003700,GO:0003723,GO:0005634,GO:0005730,GO:0006355,GO:0006364,GO:0008408,GO:0016607 DNA binding transcription factor activity|RNA binding|nucleus|nucleolus|regulation of transcription, DNA-templated|rRNA processing|3'-5' exonuclease activity|nuclear speck REXO5 208.164819814836 184.68622395046 231.643415679211 1.25425389465619 0.326829417904844 0.146779242413294 1 1.87582 1.99567 2.58231 2.52603 GeneID:81691,Genbank:XM_011545963.2,HGNC:HGNC:24661 RNA exonuclease 5 GO:0003723,GO:0004527,GO:0005730,GO:0070062 RNA binding|exonuclease activity|nucleolus|extracellular exosome hsa03008 Ribosome biogenesis in eukaryotes RFC1 1377.68449801428 1428.30812961771 1327.06086641085 0.929113850780948 -0.106072703991817 0.643355993247539 1 8.81444 7.54871 8.86562 6.59265 GeneID:5981,Genbank:NM_002913.4,HGNC:HGNC:9969,MIM:102579 replication factor C subunit 1 hsa03030,hsa03420,hsa03430 DNA replication|Nucleotide excision repair|Mismatch repair RFC2 3648.90874963931 3715.15436752724 3582.66313175139 0.964337622970957 -0.052389759937056 0.690328282224506 1 57.5003 58.6131 55.2702 60.049 GeneID:5982,Genbank:NM_001278792.1,HGNC:HGNC:9970,MIM:600404 replication factor C subunit 2 hsa03030,hsa03420,hsa03430 DNA replication|Nucleotide excision repair|Mismatch repair RFC3 899.320599786484 953.890964911958 844.750234661011 0.885583641877748 -0.175299521367504 0.269307625062814 1 3.7244 3.51124 3.45724 2.94973 GeneID:5983,Genbank:NM_181558.2,HGNC:HGNC:9971,MIM:600405 replication factor C subunit 3 hsa03030,hsa03420,hsa03430 DNA replication|Nucleotide excision repair|Mismatch repair RFC4 1494.57431814779 1553.23710249641 1435.91153379918 0.92446383845154 -0.113311206958236 0.444879573401954 1 35.4969 33.5512 30.5786 33.3762 GeneID:5984,Genbank:NM_181573.2,HGNC:HGNC:9972,MIM:102577 replication factor C subunit 4 hsa03030,hsa03420,hsa03430 DNA replication|Nucleotide excision repair|Mismatch repair RFC5 1572.23479011525 1640.22866367054 1504.24091655997 0.917092201762736 -0.124861309443298 0.389415035752673 1 10.7306 10.8564 9.9826 10.1239 GeneID:5985,Genbank:XM_024449118.1,HGNC:HGNC:9973,MIM:600407 replication factor C subunit 5 hsa03030,hsa03420,hsa03430 DNA replication|Nucleotide excision repair|Mismatch repair RFESD 17.6986279740022 16.4987315322796 18.8985244157249 1.1454531749153 0.195918483785982 0.800973813798751 1 0.194087 0.152518 0.152451 0.152897 GeneID:317671,Genbank:XM_011543361.2,HGNC:HGNC:29587 Rieske Fe-S domain containing GO:0016491,GO:0046872,GO:0051537 oxidoreductase activity|metal ion binding|2 iron, 2 sulfur cluster binding RFFL 674.005749050649 773.684044164869 574.327453936428 0.742328161305652 -0.429870994258697 0.00815641179914487 0.354981226562783 7.0272 7.53252 6.0754 4.8442 GeneID:117584,Genbank:NM_001017368.1,HGNC:HGNC:24821,MIM:609735 ring finger and FYVE like domain containing E3 ubiquitin protein ligase GO:0002020,GO:0002039,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006511,GO:0006915,GO:0010008,GO:0010762,GO:0010804,GO:0016020,GO:0019901,GO:0031625,GO:0032006,GO:0042787,GO:0043161,GO:0046872,GO:0055038,GO:0061630,GO:0070936,GO:1901797,GO:1902042,GO:2001271 protease binding|p53 binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|endosome membrane|regulation of fibroblast migration|negative regulation of tumor necrosis factor-mediated signaling pathway|membrane|protein kinase binding|ubiquitin protein ligase binding|regulation of TOR signaling|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|recycling endosome membrane|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of signal transduction by p53 class mediator|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis RFK 732.701807526804 849.488172986533 615.915442067075 0.725042986651256 -0.463861562118243 0.00922041356995127 0.375761179990686 16.7838 15.3795 10.9676 12.3596 GeneID:55312,Genbank:NM_018339.5,HGNC:HGNC:30324,MIM:613010 riboflavin kinase GO:0005524,GO:0005737,GO:0005739,GO:0005829,GO:0006771,GO:0006915,GO:0008531,GO:0009231,GO:0009398,GO:0033864,GO:0046872,GO:0072593 ATP binding|cytoplasm|mitochondrion|cytosol|riboflavin metabolic process|apoptotic process|riboflavin kinase activity|riboflavin biosynthetic process|FMN biosynthetic process|positive regulation of NAD(P)H oxidase activity|metal ion binding|reactive oxygen species metabolic process hsa00740 Riboflavin metabolism RFLNA 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0.0720169 3.00355e-07 0.141042 0.124072 GeneID:144347,Genbank:NM_181709.4,HGNC:HGNC:27051,MIM:615927 refilin A GO:0005737,GO:0005856,GO:0031005,GO:0061181,GO:0061572 cytoplasm|cytoskeleton|filamin binding|regulation of chondrocyte development|actin filament bundle organization RFLNB 592.21680136638 631.921172831954 552.512429900806 0.874337581418142 -0.193737683576515 0.245965727555998 1 8.37346 8.6381 8.25772 6.8152 GeneID:359845,Genbank:NM_182705.2,HGNC:HGNC:28705,MIM:615928 refilin B GO:0001837,GO:0005737,GO:0031005,GO:0032432,GO:0048705,GO:0061182,GO:0061572,GO:1900158 epithelial to mesenchymal transition|cytoplasm|filamin binding|actin filament bundle|skeletal system morphogenesis|negative regulation of chondrocyte development|actin filament bundle organization|negative regulation of bone mineralization involved in bone maturation RFNG 788.718400767776 746.345906859735 831.090894675818 1.1135465298827 0.155161842839237 0.332523224975191 1 15.5973 14.9805 16.8613 18.1801 GeneID:5986,Genbank:NM_002917.1,HGNC:HGNC:9974,MIM:602578 RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase GO:0005576,GO:0007389,GO:0007399,GO:0008593,GO:0009887,GO:0030154,GO:0030173,GO:0032092,GO:0033829,GO:0036066,GO:0045747,GO:0046872,GO:0070062 extracellular region|pattern specification process|nervous system development|regulation of Notch signaling pathway|animal organ morphogenesis|cell differentiation|integral component of Golgi membrane|positive regulation of protein binding|O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity|protein O-linked fucosylation|positive regulation of Notch signaling pathway|metal ion binding|extracellular exosome hsa00514,hsa04330,hsa05165 Other types of O-glycan biosynthesis|Notch signaling pathway|Human papillomavirus infection RFPL1 1.27070322989325 2.05633815719933 0.48506830258717 0.235889365223771 -2.08381771694066 0.63179572723844 1 0.0149947 0 0.00711113 0 GeneID:5988,Genbank:XM_017028902.2,HGNC:HGNC:9977,MIM:605968 ret finger protein like 1 GO:0046872 metal ion binding RFPL2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.014149 0 GeneID:10739,Genbank:XM_017028535.2,HGNC:HGNC:9979,MIM:605969 ret finger protein like 2 GO:0046872 metal ion binding RFPL4A 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0151043 0 GeneID:342931,Genbank:XM_011526915.3,HGNC:HGNC:16449,MIM:612601 ret finger protein like 4A GO:0046872 metal ion binding RFPL4AL1 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0336691 0.0346162 0 GeneID:729974,Genbank:XM_011527259.1,HGNC:HGNC:45147 ret finger protein like 4A like 1 GO:0046872 metal ion binding RFPL4B 0.972638154859436 0.490071401957362 1.45520490776151 2.96937324224464 1.5701584476161 0.837389832160054 1 0 0.0234843 0.0709468 0 GeneID:442247,Genbank:NM_001013734.2,HGNC:HGNC:33264 ret finger protein like 4B GO:0046872 metal ion binding RFT1 1050.82469813785 1057.76750181756 1043.88189445813 0.986872722658275 -0.0190640631237641 0.873546150940777 1 2.42842 2.82746 2.67004 2.47112 GeneID:91869,Genbank:XM_011534214.2,HGNC:HGNC:30220,MIM:611908 RFT1 homolog GO:0005319,GO:0005789,GO:0008643,GO:0016021,GO:0034203 lipid transporter activity|endoplasmic reticulum membrane|carbohydrate transport|integral component of membrane|glycolipid translocation RFTN1 76.0016415907451 73.4900759825337 78.5132071989566 1.06835115012831 0.0953859160174802 0.787380601604016 1 0.504831 0.432988 0.491837 0.435459 GeneID:23180,Genbank:NM_015150.1,HGNC:HGNC:30278 raftlin, lipid raft linker 1 GO:0001765,GO:0002457,GO:0003725,GO:0005737,GO:0005768,GO:0005769,GO:0005886,GO:0032596,GO:0032620,GO:0033227,GO:0034138,GO:0040007,GO:0043234,GO:0043330,GO:0045121,GO:0050852,GO:0050853,GO:0070062,GO:1903044 membrane raft assembly|T cell antigen processing and presentation|double-stranded RNA binding|cytoplasm|endosome|early endosome|plasma membrane|protein transport into membrane raft|interleukin-17 production|dsRNA transport|toll-like receptor 3 signaling pathway|growth|protein complex|response to exogenous dsRNA|membrane raft|T cell receptor signaling pathway|B cell receptor signaling pathway|extracellular exosome|protein localization to membrane raft RFTN2 2.0008072334591 2.54640955915669 1.45520490776151 0.571473234746824 -0.8072421642556 0.825091795897871 1 0.0155951 0.0151084 0.0150219 0 GeneID:130132,Genbank:XM_017003332.2,HGNC:HGNC:26402 raftlin family member 2 GO:0005737,GO:0005886,GO:0032596,GO:0033227,GO:0043330,GO:0045121,GO:0050851 cytoplasm|plasma membrane|protein transport into membrane raft|dsRNA transport|response to exogenous dsRNA|membrane raft|antigen receptor-mediated signaling pathway RFWD3 2101.59639456326 2088.69369538448 2114.49909374203 1.01235480262835 0.0177150037509744 0.901608445943845 1 12.825 13.1723 14.2049 12.6987 GeneID:55159,Genbank:XM_006721228.3,HGNC:HGNC:25539,MIM:614151 ring finger and WD repeat domain 3 GO:0000724,GO:0002039,GO:0004842,GO:0005634,GO:0005654,GO:0005737,GO:0006974,GO:0010212,GO:0016567,GO:0016605,GO:0031297,GO:0031571,GO:0036297,GO:0046872,GO:0090734,GO:0097371,GO:2000001 double-strand break repair via homologous recombination|p53 binding|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytoplasm|cellular response to DNA damage stimulus|response to ionizing radiation|protein ubiquitination|PML body|replication fork processing|mitotic G1 DNA damage checkpoint|interstrand cross-link repair|metal ion binding|site of DNA damage|MDM2/MDM4 family protein binding|regulation of DNA damage checkpoint RFX1 259.872553705853 257.55195836209 262.193149049615 1.01802040534672 0.025766479289323 0.922034144238034 1 1.86499 1.94175 1.99362 1.85506 GeneID:5989,Genbank:XM_011528170.2,HGNC:HGNC:9982,MIM:600006 regulatory factor X1 GO:0000978,GO:0003705,GO:0005634,GO:0005654,GO:0006351,GO:0006955,GO:0043231 RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|nucleoplasm|transcription, DNA-templated|immune response|intracellular membrane-bounded organelle RFX2 146.779012468808 138.966521745226 154.59150319239 1.11243701900959 0.153723659733336 0.570598341622893 1 1.12592 1.24257 1.35755 1.36293 GeneID:5990,Genbank:NM_134433.2,HGNC:HGNC:9983,MIM:142765 regulatory factor X2 GO:0000978,GO:0001675,GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0006351,GO:0006357,GO:0007286,GO:0045944,GO:0060271,GO:1990830 RNA polymerase II proximal promoter sequence-specific DNA binding|acrosome assembly|DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|spermatid development|positive regulation of transcription from RNA polymerase II promoter|cilium assembly|cellular response to leukemia inhibitory factor RFX3 133.549736222291 112.964328477016 154.135143967565 1.36445855116932 0.44832856981856 0.119219931386225 1 0.234942 0.269662 0.42463 0.291722 GeneID:5991,Genbank:NM_001282116.1,HGNC:HGNC:9984,MIM:601337 regulatory factor X3 GO:0000790,GO:0000978,GO:0003309,GO:0003677,GO:0003700,GO:0003705,GO:0005634,GO:0005667,GO:0006351,GO:0006355,GO:0031018,GO:0044212,GO:0045892,GO:0045893,GO:0045944,GO:0048469,GO:0050796,GO:0060271,GO:0060285,GO:0060287,GO:0072560,GO:2000078 nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|type B pancreatic cell differentiation|DNA binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|transcription factor complex|transcription, DNA-templated|regulation of transcription, DNA-templated|endocrine pancreas development|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|cell maturation|regulation of insulin secretion|cilium assembly|cilium-dependent cell motility|epithelial cilium movement involved in determination of left/right asymmetry|type B pancreatic cell maturation|positive regulation of type B pancreatic cell development RFX4 0.97013660517434 0 1.94027321034868 Inf Inf 0.496193947515089 1 0 0 0.00873355 0 GeneID:5992,Genbank:NM_213594.2,HGNC:HGNC:9985,MIM:603958 regulatory factor X4 GO:0000978,GO:0001077,GO:0003682,GO:0005634,GO:0021516,GO:0021537,GO:0021696,GO:0021914,GO:0030901,GO:0045944,GO:0060271,GO:0070613 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|chromatin binding|nucleus|dorsal spinal cord development|telencephalon development|cerebellar cortex morphogenesis|negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning|midbrain development|positive regulation of transcription from RNA polymerase II promoter|cilium assembly|regulation of protein processing RFX5 1860.08738510262 1904.68964793472 1815.48512227052 0.953165847380476 -0.0692008352365727 0.626103529879057 1 15.3053 15.3769 15.7057 13.6312 GeneID:5993,Genbank:XM_024448791.1,HGNC:HGNC:9986,MIM:601863 regulatory factor X5 hsa04612,hsa05152,hsa05340 Antigen processing and presentation|Tuberculosis|Primary immunodeficiency RFX7 324.552991825748 334.049089340414 315.056894311083 0.94314549676866 -0.084447745752822 0.757377219606669 1 1.09828 0.986303 1.1996 0.795688 GeneID:64864,Genbank:NM_022841.5,HGNC:HGNC:25777,MIM:612660 regulatory factor X7 GO:0000978,GO:0003700,GO:0005634,GO:0006357 RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|regulation of transcription from RNA polymerase II promoter RFX8 39.4851704256772 45.527597106495 33.4427437448594 0.734559824596771 -0.445048102221013 0.347337710357814 1 0.210324 0.19352 0.199049 0.126842 GeneID:731220,Genbank:XM_011511771.2,HGNC:HGNC:37253 RFX family member 8, lacking RFX DNA binding domain GO:0000978,GO:0003700,GO:0005634,GO:0006351,GO:0006357 RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter RFXANK 935.718359798977 944.37972852263 927.056991075325 0.981657021085783 -0.0267090422512333 0.85001292280043 1 18.9662 19.9254 19.0619 20.578 GeneID:8625,Genbank:NM_003721.3,HGNC:HGNC:9987,MIM:603200 regulatory factor X associated ankyrin containing protein hsa04612,hsa05152,hsa05340 Antigen processing and presentation|Tuberculosis|Primary immunodeficiency RFXAP 119.961604869557 114.414925372673 125.508284366441 1.09695727159403 0.133507331338227 0.621401684264696 1 2.12212 1.8619 2.01491 2.32734 GeneID:5994,Genbank:NM_000538.3,HGNC:HGNC:9988,MIM:601861 regulatory factor X associated protein hsa04612,hsa05152,hsa05340 Antigen processing and presentation|Tuberculosis|Primary immunodeficiency RGCC 1.53681553250261 2.10436443188427 0.969266633120943 0.460598277767435 -1.11841907815744 0.810667292257127 1 0.160986 0.0480063 0.0502514 0.047054 GeneID:28984,Genbank:NM_014059.2,HGNC:HGNC:20369,MIM:610077 regulator of cell cycle GO:0001100,GO:0001937,GO:0003331,GO:0005634,GO:0005730,GO:0005737,GO:0005813,GO:0005829,GO:0006956,GO:0006977,GO:0008285,GO:0010628,GO:0010718,GO:0016525,GO:0019901,GO:0030295,GO:0031659,GO:0032967,GO:0043537,GO:0045840,GO:0045944,GO:0050710,GO:0050715,GO:0051091,GO:0051496,GO:0070412,GO:0071158,GO:0071456,GO:0071850,GO:0072537,GO:0090272,GO:1901203,GO:1901991,GO:2000048,GO:2000353,GO:2000573 negative regulation of exit from mitosis|negative regulation of endothelial cell proliferation|positive regulation of extracellular matrix constituent secretion|nucleus|nucleolus|cytoplasm|centrosome|cytosol|complement activation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|negative regulation of cell proliferation|positive regulation of gene expression|positive regulation of epithelial to mesenchymal transition|negative regulation of angiogenesis|protein kinase binding|protein kinase activator activity|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle|positive regulation of collagen biosynthetic process|negative regulation of blood vessel endothelial cell migration|positive regulation of mitotic nuclear division|positive regulation of transcription from RNA polymerase II promoter|negative regulation of cytokine secretion|positive regulation of cytokine secretion|positive regulation of DNA binding transcription factor activity|positive regulation of stress fiber assembly|R-SMAD binding|positive regulation of cell cycle arrest|cellular response to hypoxia|mitotic cell cycle arrest|fibroblast activation|negative regulation of fibroblast growth factor production|positive regulation of extracellular matrix assembly|negative regulation of mitotic cell cycle phase transition|negative regulation of cell-cell adhesion mediated by cadherin|positive regulation of endothelial cell apoptotic process|positive regulation of DNA biosynthetic process RGL1 955.108123071932 925.909885726558 984.306360417305 1.06306928524143 0.0882356271764452 0.560908291550466 1 5.76886 5.5549 6.51258 5.81914 GeneID:23179,Genbank:NM_001297669.1,HGNC:HGNC:30281,MIM:605667 ral guanine nucleotide dissociation stimulator like 1 GO:0005829,GO:0007264,GO:0008321,GO:0019216 cytosol|small GTPase mediated signal transduction|Ral guanyl-nucleotide exchange factor activity|regulation of lipid metabolic process hsa04014 Ras signaling pathway RGL2 1592.61334010936 1469.19882939169 1716.02785082703 1.168002462633 0.224043316019879 0.126008833903411 1 13.4445 13.699 16.2773 16.766 GeneID:5863,Genbank:NM_001243738.1,HGNC:HGNC:9769,MIM:602306 ral guanine nucleotide dissociation stimulator like 2 GO:0005088,GO:0005089,GO:0005622,GO:0007265,GO:0010667,GO:0014068,GO:0032485 Ras guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|intracellular|Ras protein signal transduction|negative regulation of cardiac muscle cell apoptotic process|positive regulation of phosphatidylinositol 3-kinase signaling|regulation of Ral protein signal transduction hsa04014 Ras signaling pathway RGL3 79.673542328903 72.6059857279888 86.7410989298171 1.19468247776133 0.256627230232042 0.431790645799082 1 0.752605 0.779103 0.89886 1.00623 GeneID:57139,Genbank:NM_001035223.3,HGNC:HGNC:30282,MIM:616743 ral guanine nucleotide dissociation stimulator like 3 GO:0005622,GO:0007264,GO:0008321,GO:0043547 intracellular|small GTPase mediated signal transduction|Ral guanyl-nucleotide exchange factor activity|positive regulation of GTPase activity RGL4 4.2386021663398 4.60274771635603 3.87445661632358 0.84177036307151 -0.248501378511367 0.95035615279965 1 0.0245998 0.0221711 0.0115412 0.0324297 GeneID:266747,Genbank:NM_001329424.1,HGNC:HGNC:31911,MIM:612214 ral guanine nucleotide dissociation stimulator like 4 GO:0005085,GO:0007264,GO:0031410 guanyl-nucleotide exchange factor activity|small GTPase mediated signal transduction|cytoplasmic vesicle RGMA 489.386537120582 395.750059712356 583.023014528808 1.473210174504 0.558963266140522 0.00165619691449718 0.142611020336488 4.46016 4.97491 7.53534 6.80409 GeneID:56963,Genbank:NM_020211.2,HGNC:HGNC:30308,MIM:607362 repulsive guidance molecule BMP co-receptor a GO:0005886,GO:0015026,GO:0030509,GO:0031225,GO:0048681 plasma membrane|coreceptor activity|BMP signaling pathway|anchored component of membrane|negative regulation of axon regeneration RGMB 1338.90924560024 1472.42538144984 1205.39310975065 0.818644615161241 -0.288690800794 0.0499299399803274 0.815166074133459 7.7646 7.68618 7.23276 5.52637 GeneID:285704,Genbank:XM_017009391.1,HGNC:HGNC:26896,MIM:612687 repulsive guidance molecule BMP co-receptor b GO:0005793,GO:0005886,GO:0007155,GO:0007165,GO:0015026,GO:0030509,GO:0042802,GO:0045121,GO:0045893,GO:0046658 endoplasmic reticulum-Golgi intermediate compartment|plasma membrane|cell adhesion|signal transduction|coreceptor activity|BMP signaling pathway|identical protein binding|membrane raft|positive regulation of transcription, DNA-templated|anchored component of plasma membrane RGN 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.035567 0 0 GeneID:9104,Genbank:NM_152869.3,HGNC:HGNC:9989,MIM:300212 regucalcin GO:0001822,GO:0004341,GO:0005509,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006469,GO:0006874,GO:0007283,GO:0007568,GO:0008270,GO:0010867,GO:0010907,GO:0010922,GO:0019853,GO:0030234,GO:0032515,GO:0032781,GO:0034260,GO:0043066,GO:0043547,GO:0045019,GO:0045723,GO:0050680,GO:0050848,GO:0051344,GO:0097421,GO:1901318,GO:1901671,GO:1901896,GO:1902679,GO:1903011,GO:1903052,GO:1903611,GO:1903625,GO:1903629,GO:1903634,GO:2000279 kidney development|gluconolactonase activity|calcium ion binding|extracellular region|nucleus|cytoplasm|cytosol|negative regulation of protein kinase activity|cellular calcium ion homeostasis|spermatogenesis|aging|zinc ion binding|positive regulation of triglyceride biosynthetic process|positive regulation of glucose metabolic process|positive regulation of phosphatase activity|L-ascorbic acid biosynthetic process|enzyme regulator activity|negative regulation of phosphoprotein phosphatase activity|positive regulation of ATPase activity|negative regulation of GTPase activity|negative regulation of apoptotic process|positive regulation of GTPase activity|negative regulation of nitric oxide biosynthetic process|positive regulation of fatty acid biosynthetic process|negative regulation of epithelial cell proliferation|regulation of calcium-mediated signaling|negative regulation of cyclic-nucleotide phosphodiesterase activity|liver regeneration|negative regulation of flagellated sperm motility|positive regulation of superoxide dismutase activity|positive regulation of calcium-transporting ATPase activity|negative regulation of RNA biosynthetic process|negative regulation of bone development|positive regulation of proteolysis involved in cellular protein catabolic process|negative regulation of calcium-dependent ATPase activity|negative regulation of DNA catabolic process|positive regulation of dUTP diphosphatase activity|negative regulation of leucine-tRNA ligase activity|negative regulation of DNA biosynthetic process hsa00030,hsa00053 Pentose phosphate pathway|Ascorbate and aldarate metabolism RGP1 1072.86338950534 1057.71845854202 1088.00832046866 1.02863697960646 0.0407339247721542 0.801382334092018 1 20.8009 21.8236 23.1618 21.5687 GeneID:9827,Genbank:NM_001080496.2,HGNC:HGNC:21965,MIM:615742 RGP1 homolog, RAB6A GEF complex partner 1 GO:0000139,GO:0005829,GO:0005886,GO:0016020,GO:0017112,GO:0017137,GO:0032588,GO:0034066,GO:0042147,GO:0043234,GO:0043547,GO:1903363 Golgi membrane|cytosol|plasma membrane|membrane|Rab guanyl-nucleotide exchange factor activity|Rab GTPase binding|trans-Golgi network membrane|RIC1-RGP1 guanyl-nucleotide exchange factor complex|retrograde transport, endosome to Golgi|protein complex|positive regulation of GTPase activity|negative regulation of cellular protein catabolic process RGPD1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:400966,Genbank:XM_017004106.2,HGNC:HGNC:32414,MIM:612704 RANBP2-like and GRIP domain containing 1 GO:0005622,GO:0046907 intracellular|intracellular transport hsa03013 RNA transport RGPD2 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0.00362002 0 GeneID:729857,Genbank:XM_017004845.1,HGNC:HGNC:32415,MIM:612705 RANBP2-like and GRIP domain containing 2 GO:0005622,GO:0046907 intracellular|intracellular transport hsa03013 RNA transport RGPD3 1.48335117242078 1.02816907859967 1.93853326624189 1.88542264749112 0.914887962799843 0.868258168018795 1 0.0106915 0.00518924 0.0051672 0.00961167 GeneID:653489,Genbank:NM_001144013.1,HGNC:HGNC:32416,MIM:612706 RANBP2-like and GRIP domain containing 3 GO:0005622,GO:0046907 intracellular|intracellular transport hsa03013 RNA transport RGPD4 2.56248306141718 3.67063118712625 1.45433493570811 0.396208407101428 -1.3356686019521 0.584522319183761 1 0.0246615 0.00956972 0.0095452 0.0044383 GeneID:285190,Genbank:XM_017003898.1,HGNC:HGNC:32417,MIM:612707 RANBP2-like and GRIP domain containing 4 GO:0000082,GO:0005634,GO:0005737,GO:0005813,GO:0006405,GO:0006511,GO:0006606,GO:0007051,GO:0008536,GO:0043547,GO:0046604,GO:0046907 G1/S transition of mitotic cell cycle|nucleus|cytoplasm|centrosome|RNA export from nucleus|ubiquitin-dependent protein catabolic process|protein import into nucleus|spindle organization|Ran GTPase binding|positive regulation of GTPase activity|positive regulation of mitotic centrosome separation|intracellular transport hsa03013 RNA transport RGPD5 2.47186859744419 4.4586688923012 0.48506830258717 0.108792178630878 -3.2003532538878 0.282769316864862 1 0 0.0320495 0.00400636 0 GeneID:84220,Genbank:XM_006712794.4,HGNC:HGNC:32418,MIM:612708 RANBP2-like and GRIP domain containing 5 GO:0005737,GO:0046907 cytoplasm|intracellular transport hsa03013 RNA transport RGPD6 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00354647 0 0 0 GeneID:729540,Genbank:NM_001123363.3,HGNC:HGNC:32419,MIM:612709 RANBP2-like and GRIP domain containing 6 GO:0005737,GO:0046907 cytoplasm|intracellular transport RGPD8 11.5766968456092 12.9721791692082 10.1812145220102 0.784849976955078 -0.349511183797088 0.733951219067254 1 0.0493526 0.0351251 0.0477649 0.0148275 GeneID:727851,Genbank:NM_001164463.1,HGNC:HGNC:9849,MIM:602752 RANBP2-like and GRIP domain containing 8 GO:0005643,GO:0008536,GO:0046907 nuclear pore|Ran GTPase binding|intracellular transport hsa03013 RNA transport RGR 1.24418854286568 1.51824048055703 0.97013660517434 0.638987444741564 -0.646140510486663 0.974454614671682 1 0 0.0224329 0.0116424 0 GeneID:5995,Genbank:XM_024448118.1,HGNC:HGNC:9990,MIM:600342 retinal G protein coupled receptor RGS10 270.352625552527 277.557624947225 263.147626157829 0.948082857416956 -0.0769149463535986 0.727655536080038 1 8.54278 8.1269 8.42879 8.07611 GeneID:6001,Genbank:NM_001005339.1,HGNC:HGNC:9992,MIM:602856 regulator of G protein signaling 10 GO:0001965,GO:0005096,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007213,GO:0009968,GO:0043547 G-protein alpha-subunit binding|GTPase activator activity|nucleus|cytoplasm|cytosol|plasma membrane|G-protein coupled acetylcholine receptor signaling pathway|negative regulation of signal transduction|positive regulation of GTPase activity RGS11 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:8786,Genbank:NM_183337.2,HGNC:HGNC:9993,MIM:603895 regulator of G protein signaling 11 GO:0004871,GO:0005096,GO:0005737,GO:0005834,GO:0005886,GO:0007186,GO:0008277,GO:0009968,GO:0031681,GO:0035556,GO:0043234 signal transducer activity|GTPase activator activity|cytoplasm|heterotrimeric G-protein complex|plasma membrane|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|G-protein beta-subunit binding|intracellular signal transduction|protein complex RGS12 544.633817177364 542.60473316273 546.662901191998 1.00747905018376 0.0107498392393519 0.957209965742137 1 1.37867 1.44712 1.53234 1.49171 GeneID:6002,Genbank:XM_006713905.1,HGNC:HGNC:9994,MIM:602512 regulator of G protein signaling 12 GO:0000794,GO:0005057,GO:0005096,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0008277,GO:0009968,GO:0016363,GO:0030054,GO:0030425,GO:0030695,GO:0045202 condensed nuclear chromosome|signal transducer activity, downstream of receptor|GTPase activator activity|nucleus|nucleolus|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|nuclear matrix|cell junction|dendrite|GTPase regulator activity|synapse RGS14 558.111028731833 613.231832973528 502.990224490138 0.820228496702733 -0.285902227670002 0.118648848254297 1 8.24145 8.6185 6.33572 7.59044 GeneID:10636,Genbank:XM_005265795.5,HGNC:HGNC:9996,MIM:602513 regulator of G protein signaling 14 hsa04015 Rap1 signaling pathway RGS16 73.2423415437211 60.7198105671732 85.764872520269 1.41246936904371 0.498219581433741 0.184572412078575 1 0.861736 1.09218 1.18838 1.60999 GeneID:6004,Genbank:NM_002928.3,HGNC:HGNC:9997,MIM:602514 regulator of G protein signaling 16 GO:0005096,GO:0005516,GO:0005737,GO:0005886,GO:0007186,GO:0007601,GO:0008277,GO:0009968,GO:0031224,GO:0043547 GTPase activator activity|calmodulin binding|cytoplasm|plasma membrane|G-protein coupled receptor signaling pathway|visual perception|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|intrinsic component of membrane|positive regulation of GTPase activity RGS17 56.4328120265794 57.6156860211583 55.2499380320005 0.958939168262459 -0.0604887962546611 0.935565365961872 1 1.1441 0.74423 0.982329 0.66947 GeneID:26575,Genbank:NM_012419.4,HGNC:HGNC:14088,MIM:607191 regulator of G protein signaling 17 RGS18 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0105572 GeneID:64407,Genbank:NM_130782.2,HGNC:HGNC:14261,MIM:607192 regulator of G protein signaling 18 GO:0005096,GO:0005737,GO:0005886,GO:0007186,GO:0008277,GO:0009968 GTPase activator activity|cytoplasm|plasma membrane|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction RGS19 241.30713891709 186.022167987386 296.592109846795 1.59439121184152 0.673005663290364 0.0018623781881792 0.153441233527396 1.55737 1.58769 2.76781 2.47658 GeneID:10287,Genbank:XM_005260183.2,HGNC:HGNC:13735,MIM:605071 regulator of G protein signaling 19 GO:0001965,GO:0005096,GO:0005794,GO:0005903,GO:0006914,GO:0007186,GO:0007264,GO:0009968,GO:0016020,GO:0030136,GO:0031410,GO:0045121 G-protein alpha-subunit binding|GTPase activator activity|Golgi apparatus|brush border|autophagy|G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|negative regulation of signal transduction|membrane|clathrin-coated vesicle|cytoplasmic vesicle|membrane raft RGS2 48.8489200407531 48.2661117643914 49.4317283171147 1.02414979185423 0.0344267389324895 0.926621738204735 1 1.56151 0.88123 1.28235 1.24223 GeneID:5997,Genbank:NM_002923.3,HGNC:HGNC:9998,MIM:600861 regulator of G protein signaling 2 hsa04022,hsa04740,hsa04921 cGMP-PKG signaling pathway|Olfactory transduction|Oxytocin signaling pathway RGS20 100.613310633018 106.737479075626 94.4891421904109 0.88524802167628 -0.175846380355903 0.565246943857814 1 1.609 1.63505 1.29226 1.58236 GeneID:8601,Genbank:NM_170587.3,HGNC:HGNC:14600,MIM:607193 regulator of G protein signaling 20 GO:0005096,GO:0005634,GO:0005737,GO:0005802,GO:0005886,GO:0008277,GO:0009968,GO:0031410 GTPase activator activity|nucleus|cytoplasm|trans-Golgi network|plasma membrane|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|cytoplasmic vesicle RGS3 1732.34118256923 1648.29235416678 1816.39001097169 1.10198291363784 0.140101854942599 0.336851053418093 1 3.42617 3.75922 4.06062 3.89682 GeneID:5998,Genbank:XM_024447636.1,HGNC:HGNC:9999,MIM:602189 regulator of G protein signaling 3 GO:0000188,GO:0005096,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0008277 inactivation of MAPK activity|GTPase activator activity|nucleoplasm|cytoplasm|cytosol|plasma membrane|regulation of G-protein coupled receptor protein signaling pathway hsa04360 Axon guidance RGS4 2656.96132911561 2125.07159798635 3188.85106024487 1.50058523358296 0.585525266670386 0.0361701078788668 0.739837900620275 21.7633 20.7765 39.1519 26.6097 GeneID:5999,Genbank:NM_001102445.2,HGNC:HGNC:10000,MIM:602516 regulator of G protein signaling 4 GO:0000188,GO:0001965,GO:0005096,GO:0005516,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0007186,GO:0008277,GO:0043234,GO:0045744 inactivation of MAPK activity|G-protein alpha-subunit binding|GTPase activator activity|calmodulin binding|nucleus|cytoplasm|cytosol|plasma membrane|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|protein complex|negative regulation of G-protein coupled receptor protein signaling pathway RGS5 48.347026224986 47.7378227428571 48.9562297071149 1.02552288508885 0.0363596866844678 0.955904298492675 1 0.13821 0.188269 0.180168 0.143041 GeneID:8490,Genbank:NM_001254748.1,HGNC:HGNC:10001,MIM:603276 regulator of G protein signaling 5 GO:0005096,GO:0005737,GO:0005829,GO:0005886,GO:0008277,GO:0009968 GTPase activator activity|cytoplasm|cytosol|plasma membrane|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction RGS6 3.67942788806682 3.96859749034384 3.39025828578981 0.854271135845544 -0.227234057527131 0.956883261267275 1 0 0.00520121 0.00133158 0.00621389 GeneID:9628,Genbank:XM_024449761.1,HGNC:HGNC:10002,MIM:603894 regulator of G protein signaling 6 GO:0004871,GO:0005096,GO:0005634,GO:0005829,GO:0005834,GO:0005886,GO:0007186,GO:0008277,GO:0009968,GO:0019898,GO:0035556,GO:0043547 signal transducer activity|GTPase activator activity|nucleus|cytosol|heterotrimeric G-protein complex|plasma membrane|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|extrinsic component of membrane|intracellular signal transduction|positive regulation of GTPase activity RGS7 94.3251745723942 116.913308657144 71.7370404876439 0.613591739996148 -0.704649033081073 0.0221498871199587 0.605151821896072 0.500528 0.444391 0.355196 0.21495 GeneID:6000,Genbank:XM_017002004.2,HGNC:HGNC:10003,MIM:602517 regulator of G protein signaling 7 GO:0004871,GO:0005096,GO:0005634,GO:0005829,GO:0005834,GO:0005886,GO:0007186,GO:0008277,GO:0009968,GO:0031681,GO:0035556,GO:0043234,GO:0043547,GO:0044292 signal transducer activity|GTPase activator activity|nucleus|cytosol|heterotrimeric G-protein complex|plasma membrane|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|G-protein beta-subunit binding|intracellular signal transduction|protein complex|positive regulation of GTPase activity|dendrite terminus RGS7BP 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0.0106834 0.0101746 0.0102203 0 GeneID:401190,Genbank:NM_001029875.2,HGNC:HGNC:23271,MIM:610890 regulator of G protein signaling 7 binding protein GO:0005634,GO:0005737,GO:0005886,GO:0007186,GO:0009968 nucleus|cytoplasm|plasma membrane|G-protein coupled receptor signaling pathway|negative regulation of signal transduction RGS8 25.3470418166059 19.6792913174485 31.0147923157634 1.57601164673366 0.656278196356983 0.240696902598623 1 0.102407 0.0704868 0.135698 0.117604 GeneID:85397,Genbank:XM_011510089.3,HGNC:HGNC:16810,MIM:607189 regulator of G protein signaling 8 GO:0005096,GO:0005634,GO:0005737,GO:0005886,GO:0007213,GO:0009968,GO:0030425,GO:0031234,GO:0032809,GO:0043204,GO:0043547,GO:0060159 GTPase activator activity|nucleus|cytoplasm|plasma membrane|G-protein coupled acetylcholine receptor signaling pathway|negative regulation of signal transduction|dendrite|extrinsic component of cytoplasmic side of plasma membrane|neuronal cell body membrane|perikaryon|positive regulation of GTPase activity|regulation of dopamine receptor signaling pathway RGS9 20.9669707423715 14.7883859529828 27.1455555317602 1.83559961297094 0.876251407676203 0.166940315132729 1 0.108153 0.127677 0.224516 0.123478 GeneID:8787,Genbank:NM_003835.3,HGNC:HGNC:10004,MIM:604067 regulator of G protein signaling 9 GO:0001917,GO:0004871,GO:0005096,GO:0005634,GO:0005737,GO:0005834,GO:0005886,GO:0006457,GO:0007212,GO:0007399,GO:0007601,GO:0008277,GO:0009968,GO:0032403,GO:0035556,GO:0043627,GO:0097381 photoreceptor inner segment|signal transducer activity|GTPase activator activity|nucleus|cytoplasm|heterotrimeric G-protein complex|plasma membrane|protein folding|dopamine receptor signaling pathway|nervous system development|visual perception|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|protein complex binding|intracellular signal transduction|response to estrogen|photoreceptor disc membrane hsa04744,hsa05030 Phototransduction|Cocaine addiction RGS9BP 29.5326146088906 23.2058436805199 35.8593855372613 1.54527394181162 0.627862617715276 0.228785711078807 1 0.573532 0.431928 0.725049 0.820706 GeneID:388531,Genbank:NM_207391.2,HGNC:HGNC:30304,MIM:607814 regulator of G protein signaling 9 binding protein GO:0001750,GO:0009968,GO:0016021,GO:0050908 photoreceptor outer segment|negative regulation of signal transduction|integral component of membrane|detection of light stimulus involved in visual perception RHBDD1 310.066499685135 307.528415705778 312.604583664492 1.0165063379495 0.02361921046037 0.908897617203155 1 1.37354 1.35771 1.48171 1.30517 GeneID:84236,Genbank:NM_001349069.1,HGNC:HGNC:23081,MIM:617515 rhomboid domain containing 1 GO:0004175,GO:0004252,GO:0005739,GO:0005783,GO:0005789,GO:0006915,GO:0010954,GO:0030176,GO:0031293,GO:0033619,GO:0034620,GO:0034644,GO:0036503,GO:0043066,GO:0043687,GO:0044322,GO:0045732,GO:0048515,GO:0051047,GO:1904211 endopeptidase activity|serine-type endopeptidase activity|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|apoptotic process|positive regulation of protein processing|integral component of endoplasmic reticulum membrane|membrane protein intracellular domain proteolysis|membrane protein proteolysis|cellular response to unfolded protein|cellular response to UV|ERAD pathway|negative regulation of apoptotic process|post-translational protein modification|endoplasmic reticulum quality control compartment|positive regulation of protein catabolic process|spermatid differentiation|positive regulation of secretion|membrane protein proteolysis involved in retrograde protein transport, ER to cytosol RHBDD2 1496.5027980291 1398.10127548915 1594.90432056904 1.14076451293633 0.190001008031281 0.199125966171042 1 19.0451 20.9535 23.3942 22.9933 GeneID:57414,Genbank:NM_001346186.1,HGNC:HGNC:23082,MIM:615203 rhomboid domain containing 2 GO:0000139,GO:0004252,GO:0005634,GO:0005654,GO:0005794,GO:0016021,GO:0048471 Golgi membrane|serine-type endopeptidase activity|nucleus|nucleoplasm|Golgi apparatus|integral component of membrane|perinuclear region of cytoplasm RHBDD3 413.609726391084 381.365501267069 445.8539515151 1.16909880425411 0.225396861763336 0.237357170784168 1 3.66608 4.61514 5.06963 4.91324 GeneID:25807,Genbank:NM_001329536.1,HGNC:HGNC:1308 rhomboid domain containing 3 GO:0000165,GO:0001889,GO:0002673,GO:0004252,GO:0005622,GO:0009410,GO:0016021,GO:0032815,GO:0045732,GO:0050708 MAPK cascade|liver development|regulation of acute inflammatory response|serine-type endopeptidase activity|intracellular|response to xenobiotic stimulus|integral component of membrane|negative regulation of natural killer cell activation|positive regulation of protein catabolic process|regulation of protein secretion RHBDF1 596.463303908215 564.869668659767 628.056939156662 1.11186168067196 0.152977323114825 0.379289491703436 1 5.79805 5.77336 6.77971 6.7927 GeneID:64285,Genbank:XM_005255494.1,HGNC:HGNC:20561,MIM:614403 rhomboid 5 homolog 1 GO:0000139,GO:0005789,GO:0006508,GO:0008283,GO:0015031,GO:0016021,GO:0016477,GO:0019838,GO:0042058,GO:0050708,GO:0050709,GO:0061136 Golgi membrane|endoplasmic reticulum membrane|proteolysis|cell proliferation|protein transport|integral component of membrane|cell migration|growth factor binding|regulation of epidermal growth factor receptor signaling pathway|regulation of protein secretion|negative regulation of protein secretion|regulation of proteasomal protein catabolic process RHBDF2 281.186877274442 269.198002149481 293.175752399403 1.0890710557228 0.123098084812102 0.552691488488279 1 1.75323 1.61651 1.75399 2.18605 GeneID:79651,Genbank:XM_011525250.2,HGNC:HGNC:20788,MIM:614404 rhomboid 5 homolog 2 GO:0005789,GO:0005886,GO:0006508,GO:0015031,GO:0016021,GO:0019838,GO:0042058,GO:0050708,GO:0050709 endoplasmic reticulum membrane|plasma membrane|proteolysis|protein transport|integral component of membrane|growth factor binding|regulation of epidermal growth factor receptor signaling pathway|regulation of protein secretion|negative regulation of protein secretion RHBDL1 4.66813954518674 3.03648096111406 6.29979812925943 2.07470364870923 1.05290527618419 0.502159996744781 1 0.0383643 0.0315971 0.174742 0.130217 GeneID:9028,Genbank:NM_001278720.1,HGNC:HGNC:10007,MIM:603264 rhomboid like 1 GO:0004252,GO:0016021,GO:0016485 serine-type endopeptidase activity|integral component of membrane|protein processing RHBDL2 12.1513025018246 11.7038787171838 12.5987262864655 1.07645735152466 0.106291162085056 0.963611301890907 1 0.150165 0.0804711 0.0615844 0.190274 GeneID:54933,Genbank:NM_017821.4,HGNC:HGNC:16083,MIM:608962 rhomboid like 2 GO:0004252,GO:0005886,GO:0016021,GO:0016485 serine-type endopeptidase activity|plasma membrane|integral component of membrane|protein processing RHBDL3 56.630665612537 48.3239466941843 64.9373845308896 1.3437930668586 0.4263109919841 0.265823494943266 1 0.200767 0.179325 0.347807 0.296866 GeneID:162494,Genbank:XM_017024272.1,HGNC:HGNC:16502 rhomboid like 3 GO:0004252,GO:0005509,GO:0016021,GO:0016485 serine-type endopeptidase activity|calcium ion binding|integral component of membrane|protein processing RHCE 80.4892619035305 106.71786176541 54.2606620416515 0.508449674159784 -0.975823110250342 0.0856355238727008 0.964561165794104 1.06544 0.667947 0.326606 0.63568 GeneID:6006,Genbank:XM_011541889.3,HGNC:HGNC:10008,MIM:111700 Rh blood group CcEe antigens RHEB 5898.87134702954 6276.93131758226 5520.81137647683 0.879539873411157 -0.185179111995601 0.158531415428283 1 93.3831 94.7483 84.5409 83.5207 GeneID:6009,Genbank:NM_005614.3,HGNC:HGNC:10011,MIM:601293 Ras homolog, mTORC1 binding GO:0000139,GO:0000287,GO:0003924,GO:0005525,GO:0005681,GO:0005765,GO:0005789,GO:0005829,GO:0007050,GO:0007165,GO:0016020,GO:0016241,GO:0019003,GO:0019901,GO:0032008,GO:0048714,GO:0070062,GO:2000074 Golgi membrane|magnesium ion binding|GTPase activity|GTP binding|spliceosomal complex|lysosomal membrane|endoplasmic reticulum membrane|cytosol|cell cycle arrest|signal transduction|membrane|regulation of macroautophagy|GDP binding|protein kinase binding|positive regulation of TOR signaling|positive regulation of oligodendrocyte differentiation|extracellular exosome|regulation of type B pancreatic cell development hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04714,hsa04910,hsa04919,hsa05163,hsa05165,hsa05231 Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Thermogenesis|Insulin signaling pathway|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Choline metabolism in cancer RHEBL1 48.0166832781024 46.1235297129302 49.9098368432747 1.08209057619636 0.113821264747121 0.808089810630193 1 1.28207 1.33837 0.870814 1.44432 GeneID:121268,Genbank:NM_144593.2,HGNC:HGNC:21166 RHEB like 1 GO:0003924,GO:0005525,GO:0005737,GO:0012505,GO:0016020,GO:0031929,GO:0046872,GO:0051092 GTPase activity|GTP binding|cytoplasm|endomembrane system|membrane|TOR signaling|metal ion binding|positive regulation of NF-kappaB transcription factor activity RHNO1 826.449471053166 872.148144337012 780.75079776932 0.895204332932256 -0.159711075681244 0.303936752075006 1 15.1578 16.4263 14.7591 13.6243 GeneID:83695,Genbank:NM_001257097.1,HGNC:HGNC:28206,MIM:614085 RAD9-HUS1-RAD1 interacting nuclear orphan 1 GO:0000077,GO:0000725,GO:0005634,GO:0005654,GO:0005694,GO:0006260,GO:0007049,GO:0034644,GO:0070318,GO:0071479,GO:1901796 DNA damage checkpoint|recombinational repair|nucleus|nucleoplasm|chromosome|DNA replication|cell cycle|cellular response to UV|positive regulation of G0 to G1 transition|cellular response to ionizing radiation|regulation of signal transduction by p53 class mediator RHOA 18650.5939953381 18497.181167882 18804.0068227943 1.01658769799179 0.0237346775539059 0.865403107130091 1 296.512 316.619 314.203 315.711 GeneID:387,Genbank:NM_001313945.1,HGNC:HGNC:667,MIM:165390 ras homolog family member A GO:0000902,GO:0001998,GO:0002363,GO:0003100,GO:0003924,GO:0005525,GO:0005634,GO:0005739,GO:0005768,GO:0005829,GO:0005856,GO:0005938,GO:0006357,GO:0007160,GO:0007266,GO:0007519,GO:0010812,GO:0010975,GO:0016477,GO:0017022,GO:0021795,GO:0021861,GO:0030027,GO:0030334,GO:0030496,GO:0030521,GO:0031234,GO:0031532,GO:0032154,GO:0032467,GO:0032587,GO:0033144,GO:0033688,GO:0034329,GO:0035385,GO:0036089,GO:0038027,GO:0042476,GO:0043123,GO:0043149,GO:0043197,GO:0043296,GO:0043297,GO:0043366,GO:0043524,GO:0043542,GO:0043931,GO:0044319,GO:0045198,GO:0045666,GO:0045792,GO:0046638,GO:0050919,GO:0051496,GO:0060193,GO:0061383,GO:0070507,GO:0071222,GO:0071803,GO:0071902,GO:0090051,GO:0090307,GO:0090324,GO:0097498,GO:1902766,GO:1903427,GO:1903673,GO:1904695,GO:1990869,GO:2000177,GO:2000406 cell morphogenesis|angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure|alpha-beta T cell lineage commitment|regulation of systemic arterial blood pressure by endothelin|GTPase activity|GTP binding|nucleus|mitochondrion|endosome|cytosol|cytoskeleton|cell cortex|regulation of transcription from RNA polymerase II promoter|cell-matrix adhesion|Rho protein signal transduction|skeletal muscle tissue development|negative regulation of cell-substrate adhesion|regulation of neuron projection development|cell migration|myosin binding|cerebral cortex cell migration|forebrain radial glial cell differentiation|lamellipodium|regulation of cell migration|midbody|androgen receptor signaling pathway|extrinsic component of cytoplasmic side of plasma membrane|actin cytoskeleton reorganization|cleavage furrow|positive regulation of cytokinesis|ruffle membrane|negative regulation of intracellular steroid hormone receptor signaling pathway|regulation of osteoblast proliferation|cell junction assembly|Roundabout signaling pathway|cleavage furrow formation|apolipoprotein A-I-mediated signaling pathway|odontogenesis|positive regulation of I-kappaB kinase/NF-kappaB signaling|stress fiber assembly|dendritic spine|apical junction complex|apical junction assembly|beta selection|negative regulation of neuron apoptotic process|endothelial cell migration|ossification involved in bone maturation|wound healing, spreading of cells|establishment of epithelial cell apical/basal polarity|positive regulation of neuron differentiation|negative regulation of cell size|positive regulation of alpha-beta T cell differentiation|negative chemotaxis|positive regulation of stress fiber assembly|positive regulation of lipase activity|trabecula morphogenesis|regulation of microtubule cytoskeleton organization|cellular response to lipopolysaccharide|positive regulation of podosome assembly|positive regulation of protein serine/threonine kinase activity|negative regulation of cell migration involved in sprouting angiogenesis|mitotic spindle assembly|negative regulation of oxidative phosphorylation|endothelial tube lumen extension|skeletal muscle satellite cell migration|negative regulation of reactive oxygen species biosynthetic process|mitotic cleavage furrow formation|positive regulation of vascular smooth muscle contraction|cellular response to chemokine|regulation of neural precursor cell proliferation|positive regulation of T cell migration hsa04014,hsa04015,hsa04022,hsa04024,hsa04062,hsa04071,hsa04072,hsa04144,hsa04150,hsa04270,hsa04310,hsa04350,hsa04360,hsa04510,hsa04520,hsa04530,hsa04611,hsa04621,hsa04625,hsa04660,hsa04670,hsa04722,hsa04810,hsa04921,hsa04928,hsa04972,hsa05100,hsa05130,hsa05133,hsa05152,hsa05163,hsa05200,hsa05203,hsa05205,hsa05206,hsa05210,hsa05418 Ras signaling pathway|Rap1 signaling pathway|cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|Endocytosis|mTOR signaling pathway|Vascular smooth muscle contraction|Wnt signaling pathway|TGF-beta signaling pathway|Axon guidance|Focal adhesion|Adherens junction|Tight junction|Platelet activation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|T cell receptor signaling pathway|Leukocyte transendothelial migration|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Parathyroid hormone synthesis, secretion and action|Pancreatic secretion|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Pertussis|Tuberculosis|Human cytomegalovirus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Fluid shear stress and atherosclerosis RHOB 3630.8813890438 3516.49823829515 3745.26453979244 1.06505514463394 0.0909281298222902 0.516680957282757 1 81.2369 85.5733 94.503 86.9924 GeneID:388,Genbank:NM_004040.3,HGNC:HGNC:668,MIM:165370 ras homolog family member B GO:0000281,GO:0001525,GO:0003924,GO:0005525,GO:0005634,GO:0005769,GO:0005770,GO:0005829,GO:0005886,GO:0005925,GO:0006886,GO:0006915,GO:0007155,GO:0007264,GO:0008333,GO:0010008,GO:0010595,GO:0016020,GO:0019003,GO:0030154,GO:0030334,GO:0030336,GO:0031902,GO:0032154,GO:0043065,GO:0045766,GO:0045786,GO:0061154,GO:0070062,GO:0070301,GO:0071479 mitotic cytokinesis|angiogenesis|GTPase activity|GTP binding|nucleus|early endosome|late endosome|cytosol|plasma membrane|focal adhesion|intracellular protein transport|apoptotic process|cell adhesion|small GTPase mediated signal transduction|endosome to lysosome transport|endosome membrane|positive regulation of endothelial cell migration|membrane|GDP binding|cell differentiation|regulation of cell migration|negative regulation of cell migration|late endosome membrane|cleavage furrow|positive regulation of apoptotic process|positive regulation of angiogenesis|negative regulation of cell cycle|endothelial tube morphogenesis|extracellular exosome|cellular response to hydrogen peroxide|cellular response to ionizing radiation RHOBTB1 497.56158975721 514.844168040539 480.279011473881 0.932862876356917 -0.10026306326233 0.567234987409033 1 1.55999 1.60667 1.52985 1.38408 GeneID:9886,Genbank:XM_024448271.1,HGNC:HGNC:18738,MIM:607351 Rho related BTB domain containing 1 hsa04120 Ubiquitin mediated proteolysis RHOBTB2 1001.20755290095 943.015375521235 1059.39973028066 1.12341723982506 0.167893847622605 0.282739503050494 1 3.22879 3.45758 3.89807 3.71015 GeneID:23221,Genbank:XM_017013251.1,HGNC:HGNC:18756,MIM:607352 Rho related BTB domain containing 2 hsa04120 Ubiquitin mediated proteolysis RHOBTB3 3357.13124169574 3689.37842897393 3024.88405441755 0.819889884610947 -0.286497933441136 0.0669320299912594 0.912266462842959 25.525 24.618 23.719 17.8598 GeneID:22836,Genbank:XM_017009237.1,HGNC:HGNC:18757,MIM:607353 Rho related BTB domain containing 3 GO:0003924,GO:0005524,GO:0005829,GO:0008584,GO:0016887,GO:0017137,GO:0032588,GO:0042147,GO:0070062 GTPase activity|ATP binding|cytosol|male gonad development|ATPase activity|Rab GTPase binding|trans-Golgi network membrane|retrograde transport, endosome to Golgi|extracellular exosome RHOC 6954.5978831357 6805.09772537333 7104.09804089806 1.04393769606128 0.0620356120365023 0.709496548287833 1 170.876 175.657 173.778 197.34 GeneID:389,Genbank:NM_001042678.1,HGNC:HGNC:669,MIM:165380 ras homolog family member C RHOD 111.994058944948 108.64973840877 115.338379481125 1.06156150185278 0.0861879565920461 0.779105803874082 1 5.65341 4.98462 5.90688 5.68011 GeneID:29984,Genbank:NM_014578.3,HGNC:HGNC:670,MIM:605781 ras homolog family member D GO:0003924,GO:0005525,GO:0005769,GO:0005829,GO:0005886,GO:0006605,GO:0007266,GO:0010008,GO:0019901,GO:0030032,GO:0030335,GO:0045785,GO:0048041,GO:0051017,GO:0051056,GO:0051893,GO:2000249 GTPase activity|GTP binding|early endosome|cytosol|plasma membrane|protein targeting|Rho protein signal transduction|endosome membrane|protein kinase binding|lamellipodium assembly|positive regulation of cell migration|positive regulation of cell adhesion|focal adhesion assembly|actin filament bundle assembly|regulation of small GTPase mediated signal transduction|regulation of focal adhesion assembly|regulation of actin cytoskeleton reorganization hsa04360 Axon guidance RHOF 30.4843214557693 33.8335270444191 27.1351158671194 0.802018537159737 -0.31829251262193 0.551619060236537 1 0.484171 0.421162 0.286751 0.503541 GeneID:54509,Genbank:NM_019034.2,HGNC:HGNC:15703 ras homolog family member F, filopodia associated GO:0003924,GO:0005525,GO:0005829,GO:0005856,GO:0005886,GO:0007015,GO:0007264,GO:0030667,GO:0043312,GO:0051056,GO:0070062 GTPase activity|GTP binding|cytosol|cytoskeleton|plasma membrane|actin filament organization|small GTPase mediated signal transduction|secretory granule membrane|neutrophil degranulation|regulation of small GTPase mediated signal transduction|extracellular exosome RHOG 925.767628271793 916.225144547851 935.310111995734 1.02082999747546 0.0297426289775846 0.86681954177531 1 25.3222 25.5416 26.1644 26.5528 GeneID:391,Genbank:NM_001665.3,HGNC:HGNC:672,MIM:179505 ras homolog family member G GO:0003924,GO:0005525,GO:0005789,GO:0005829,GO:0005886,GO:0005925,GO:0007186,GO:0007266,GO:0008284,GO:0016601,GO:0030036,GO:0030168,GO:0030667,GO:0043312,GO:0045893,GO:0051056,GO:0060326,GO:0070062,GO:0090630,GO:1900027,GO:1903078 GTPase activity|GTP binding|endoplasmic reticulum membrane|cytosol|plasma membrane|focal adhesion|G-protein coupled receptor signaling pathway|Rho protein signal transduction|positive regulation of cell proliferation|Rac protein signal transduction|actin cytoskeleton organization|platelet activation|secretory granule membrane|neutrophil degranulation|positive regulation of transcription, DNA-templated|regulation of small GTPase mediated signal transduction|cell chemotaxis|extracellular exosome|activation of GTPase activity|regulation of ruffle assembly|positive regulation of protein localization to plasma membrane hsa05100,hsa05131,hsa05132 Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection RHOJ 1020.61492640162 1059.36014353556 981.869709267675 0.926851661598988 -0.109589634353741 0.485148188398315 1 10.6515 10.0852 9.82213 9.26743 GeneID:57381,Genbank:NM_020663.4,HGNC:HGNC:688,MIM:607653 ras homolog family member J GO:0003924,GO:0005525,GO:0005829,GO:0005886,GO:0007266,GO:0008360,GO:0030036,GO:0051056,GO:0061299,GO:0070062 GTPase activity|GTP binding|cytosol|plasma membrane|Rho protein signal transduction|regulation of cell shape|actin cytoskeleton organization|regulation of small GTPase mediated signal transduction|retina vasculature morphogenesis in camera-type eye|extracellular exosome RHOQ 788.316435912784 837.573588861249 739.059282964319 0.882381312869633 -0.180525857126455 0.263053478513043 1 6.94035 6.73899 6.21747 5.96022 GeneID:23433,Genbank:XM_017003716.1,HGNC:HGNC:17736,MIM:605857 ras homolog family member Q GO:0003924,GO:0005522,GO:0005525,GO:0005829,GO:0005884,GO:0005886,GO:0007264,GO:0008286,GO:0008360,GO:0030660,GO:0030866,GO:0032427,GO:0032869,GO:0032956,GO:0045121,GO:0045944,GO:0046039,GO:0046326,GO:0051056,GO:0051491,GO:0070062,GO:1903077 GTPase activity|profilin binding|GTP binding|cytosol|actin filament|plasma membrane|small GTPase mediated signal transduction|insulin receptor signaling pathway|regulation of cell shape|Golgi-associated vesicle membrane|cortical actin cytoskeleton organization|GBD domain binding|cellular response to insulin stimulus|regulation of actin cytoskeleton organization|membrane raft|positive regulation of transcription from RNA polymerase II promoter|GTP metabolic process|positive regulation of glucose import|regulation of small GTPase mediated signal transduction|positive regulation of filopodium assembly|extracellular exosome|negative regulation of protein localization to plasma membrane hsa04910 Insulin signaling pathway RHOT1 569.269967049751 600.575203416044 537.964730683458 0.895749154516436 -0.158833318187907 0.36854767787865 1 2.96383 2.48687 2.68098 2.24907 GeneID:55288,Genbank:NM_001288758.1,HGNC:HGNC:21168,MIM:613888 ras homolog family member T1 GO:0003924,GO:0005509,GO:0005525,GO:0019725,GO:0031307,GO:0047497,GO:0097345 GTPase activity|calcium ion binding|GTP binding|cellular homeostasis|integral component of mitochondrial outer membrane|mitochondrion transport along microtubule|mitochondrial outer membrane permeabilization hsa04137 Mitophagy - animal RHOT2 1257.04353076568 1285.09872939256 1228.98833213879 0.956337675876241 -0.0644079816028392 0.64279878039833 1 14.0877 15.2789 14.4325 14.2734 GeneID:89941,Genbank:NM_001352275.1,HGNC:HGNC:21169,MIM:613889 ras homolog family member T2 GO:0003924,GO:0005509,GO:0005525,GO:0005829,GO:0005886,GO:0016020,GO:0019725,GO:0031307,GO:0047497,GO:0051056,GO:0070062,GO:0097345 GTPase activity|calcium ion binding|GTP binding|cytosol|plasma membrane|membrane|cellular homeostasis|integral component of mitochondrial outer membrane|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|extracellular exosome|mitochondrial outer membrane permeabilization hsa04137 Mitophagy - animal RHOU 242.458860193688 200.925206799099 283.992513588276 1.41342402037308 0.499194332141753 0.0181169442961104 0.548508468518913 2.33025 2.01634 3.20824 3.02826 GeneID:58480,Genbank:NM_021205.5,HGNC:HGNC:17794,MIM:606366 ras homolog family member U GO:0000082,GO:0000139,GO:0002102,GO:0003924,GO:0005525,GO:0005829,GO:0005886,GO:0005925,GO:0007010,GO:0008360,GO:0016601,GO:0019221,GO:0030036,GO:0042995,GO:0046872,GO:0051056,GO:1903955 G1/S transition of mitotic cell cycle|Golgi membrane|podosome|GTPase activity|GTP binding|cytosol|plasma membrane|focal adhesion|cytoskeleton organization|regulation of cell shape|Rac protein signal transduction|cytokine-mediated signaling pathway|actin cytoskeleton organization|cell projection|metal ion binding|regulation of small GTPase mediated signal transduction|positive regulation of protein targeting to mitochondrion RHOV 22.5389067422817 24.7240841610769 20.3537293234864 0.823234915027883 -0.280623923795688 0.672150095273136 1 0.769988 0.628742 0.576444 0.563521 GeneID:171177,Genbank:NM_133639.3,HGNC:HGNC:18313 ras homolog family member V GO:0003924,GO:0005525,GO:0005829,GO:0005886,GO:0007264,GO:0010008,GO:0046872,GO:0051056 GTPase activity|GTP binding|cytosol|plasma membrane|small GTPase mediated signal transduction|endosome membrane|metal ion binding|regulation of small GTPase mediated signal transduction RHPN1 106.160546928038 109.10159219115 103.219501664927 0.946086116544311 -0.0799565854697989 0.773505369325637 1 0.606203 0.691923 0.653127 0.587081 GeneID:114822,Genbank:XM_011516823.2,HGNC:HGNC:19973,MIM:601031 rhophilin Rho GTPase binding protein 1 GO:0005829,GO:0007165 cytosol|signal transduction RHPN2 1303.16003284883 1289.04669257183 1317.27337312582 1.02189732979933 0.0312502557373609 0.837885849956458 1 14.1437 14.1201 15.8335 13.7531 GeneID:85415,Genbank:NM_033103.4,HGNC:HGNC:19974 rhophilin Rho GTPase binding protein 2 GO:0005829,GO:0007165,GO:0048471 cytosol|signal transduction|perinuclear region of cytoplasm RIBC1 9.67986889040715 7.24520982488261 12.1145279559317 1.67207413570358 0.741638814428849 0.441571171483859 1 0.0512318 0.0234735 0.0362 0.112646 GeneID:158787,Genbank:NM_001031745.4,HGNC:HGNC:26537 RIB43A domain with coiled-coils 1 RIBC2 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0 GeneID:26150,Genbank:NM_015653.4,HGNC:HGNC:13241 RIB43A domain with coiled-coils 2 GO:0005634 nucleus RIC1 645.120561609998 760.537343205428 529.703780014569 0.696486220889605 -0.521833283698845 0.00173327367939649 0.148449792776546 3.09853 3.04146 2.2704 2.03043 GeneID:57589,Genbank:XM_005251523.3,HGNC:HGNC:17686,MIM:610354 RIC1 homolog, RAB6A GEF complex partner 1 GO:0000139,GO:0005829,GO:0006886,GO:0016020,GO:0016021,GO:0017112,GO:0017137,GO:0032588,GO:0034066,GO:0042147,GO:0043234,GO:0043547,GO:1903363 Golgi membrane|cytosol|intracellular protein transport|membrane|integral component of membrane|Rab guanyl-nucleotide exchange factor activity|Rab GTPase binding|trans-Golgi network membrane|RIC1-RGP1 guanyl-nucleotide exchange factor complex|retrograde transport, endosome to Golgi|protein complex|positive regulation of GTPase activity|negative regulation of cellular protein catabolic process RIC3 2.22182979709531 2.98845468642911 1.45520490776151 0.486942269651853 -1.03817735384037 0.699589878865354 1 0.00502934 0.0191734 0.00967674 0 GeneID:79608,Genbank:XM_017018287.2,HGNC:HGNC:30338,MIM:610509 RIC3 acetylcholine receptor chaperone GO:0000139,GO:0005789,GO:0007204,GO:0007271,GO:0016021,GO:0033130,GO:0034394,GO:0043005,GO:0043025,GO:0043231,GO:0043623,GO:0044183 Golgi membrane|endoplasmic reticulum membrane|positive regulation of cytosolic calcium ion concentration|synaptic transmission, cholinergic|integral component of membrane|acetylcholine receptor binding|protein localization to cell surface|neuron projection|neuronal cell body|intracellular membrane-bounded organelle|cellular protein complex assembly|protein binding involved in protein folding RIC8A 3028.93939733223 2917.0168135409 3140.86198112356 1.07673770221123 0.106666846161442 0.448087892471799 1 27.0701 27.4655 30.8294 29.3254 GeneID:60626,Genbank:NM_021932.5,HGNC:HGNC:29550,MIM:609146 RIC8 guanine nucleotide exchange factor A GO:0001701,GO:0001944,GO:0001965,GO:0005085,GO:0005096,GO:0005737,GO:0005886,GO:0007186,GO:0007193,GO:0008542,GO:0042074,GO:0070586,GO:0071711 in utero embryonic development|vasculature development|G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|cytoplasm|plasma membrane|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|visual learning|cell migration involved in gastrulation|cell-cell adhesion involved in gastrulation|basement membrane organization RIC8B 328.633526592492 326.255973183781 331.011080001202 1.01457477320957 0.0208751942847162 0.894316442889495 1 2.13041 1.85649 2.17043 1.90551 GeneID:55188,Genbank:NM_001351361.1,HGNC:HGNC:25555,MIM:609147 RIC8 guanine nucleotide exchange factor B GO:0001965,GO:0005085,GO:0005096,GO:0005813,GO:0005829,GO:0005886,GO:0005938,GO:0008277 G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity|GTPase activator activity|centrosome|cytosol|plasma membrane|cell cortex|regulation of G-protein coupled receptor protein signaling pathway RICTOR 113.737867872914 112.108647186941 115.367088558887 1.02906503158952 0.0413341559803217 0.912271687608531 1 0.462604 0.361752 0.563809 0.298321 GeneID:253260,Genbank:XM_006714463.3,HGNC:HGNC:28611,MIM:609022 RPTOR independent companion of MTOR complex 2 GO:0001938,GO:0005829,GO:0008047,GO:0009790,GO:0010468,GO:0018105,GO:0019901,GO:0030010,GO:0030838,GO:0030950,GO:0031532,GO:0031929,GO:0031932,GO:0032008,GO:0032148,GO:0032956,GO:0033135,GO:0042325,GO:0043022,GO:0043087,GO:0050727,GO:0050731,GO:0051896,GO:0051897,GO:2000114 positive regulation of endothelial cell proliferation|cytosol|enzyme activator activity|embryo development|regulation of gene expression|peptidyl-serine phosphorylation|protein kinase binding|establishment of cell polarity|positive regulation of actin filament polymerization|establishment or maintenance of actin cytoskeleton polarity|actin cytoskeleton reorganization|TOR signaling|TORC2 complex|positive regulation of TOR signaling|activation of protein kinase B activity|regulation of actin cytoskeleton organization|regulation of peptidyl-serine phosphorylation|regulation of phosphorylation|ribosome binding|regulation of GTPase activity|regulation of inflammatory response|positive regulation of peptidyl-tyrosine phosphorylation|regulation of protein kinase B signaling|positive regulation of protein kinase B signaling|regulation of establishment of cell polarity hsa04150 mTOR signaling pathway RIDA 114.15955389735 136.24660739669 92.072500398009 0.675778297583104 -0.56537807535928 0.0486563787553657 0.806708656465773 5.66085 4.79512 3.60409 3.90177 GeneID:10247,Genbank:NM_005836.2,HGNC:HGNC:16897,MIM:602487 reactive intermediate imine deaminase A homolog GO:0001822,GO:0003723,GO:0005634,GO:0005737,GO:0005759,GO:0005777,GO:0005829,GO:0007420,GO:0016892,GO:0017148,GO:0019239,GO:0030324,GO:0033993,GO:0036041,GO:0042803,GO:0046914,GO:0050680,GO:0070062,GO:0070314,GO:1901565,GO:1902074,GO:1904012,GO:1904013 kidney development|RNA binding|nucleus|cytoplasm|mitochondrial matrix|peroxisome|cytosol|brain development|endoribonuclease activity, producing 3'-phosphomonoesters|negative regulation of translation|deaminase activity|lung development|response to lipid|long-chain fatty acid binding|protein homodimerization activity|transition metal ion binding|negative regulation of epithelial cell proliferation|extracellular exosome|G1 to G0 transition|organonitrogen compound catabolic process|response to salt|platinum binding|xenon atom binding RIF1 145.886442809498 144.904196497652 146.868689121345 1.01355718240862 0.0194274844142437 0.94385871233063 1 0.419841 0.309168 0.473821 0.299579 GeneID:55183,Genbank:NM_018151.4,HGNC:HGNC:23207,MIM:608952 replication timing regulatory factor 1 GO:0000122,GO:0000723,GO:0000781,GO:0000790,GO:0000793,GO:0001939,GO:0001940,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006303,GO:0006348,GO:0006974,GO:0007049,GO:0016604,GO:0019827,GO:0031965,GO:0035861,GO:0043247,GO:0045830,GO:0051233,GO:0051574,GO:1990830,GO:2000042,GO:2001034 negative regulation of transcription from RNA polymerase II promoter|telomere maintenance|chromosome, telomeric region|nuclear chromatin|condensed chromosome|female pronucleus|male pronucleus|nucleus|nucleoplasm|cytoplasm|plasma membrane|double-strand break repair via nonhomologous end joining|chromatin silencing at telomere|cellular response to DNA damage stimulus|cell cycle|nuclear body|stem cell population maintenance|nuclear membrane|site of double-strand break|telomere maintenance in response to DNA damage|positive regulation of isotype switching|spindle midzone|positive regulation of histone H3-K9 methylation|cellular response to leukemia inhibitory factor|negative regulation of double-strand break repair via homologous recombination|positive regulation of double-strand break repair via nonhomologous end joining hsa04550 Signaling pathways regulating pluripotency of stem cells RILP 86.322618692182 77.6605872267252 94.9846501576388 1.22307406561757 0.290511771701543 0.374955959671619 1 1.89074 2.22653 2.5429 2.49582 GeneID:83547,Genbank:NM_031430.2,HGNC:HGNC:30266,MIM:607848 Rab interacting lysosomal protein GO:0005739,GO:0005764,GO:0005765,GO:0005770,GO:0005829,GO:0008333,GO:0010796,GO:0015031,GO:0017137,GO:0019886,GO:0030670,GO:0031267,GO:0031902,GO:0032509,GO:0036064,GO:0042177,GO:0043234,GO:0045022,GO:0045732,GO:0046983,GO:0051959,GO:0060271,GO:0070676 mitochondrion|lysosome|lysosomal membrane|late endosome|cytosol|endosome to lysosome transport|regulation of multivesicular body size|protein transport|Rab GTPase binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|phagocytic vesicle membrane|small GTPase binding|late endosome membrane|endosome transport via multivesicular body sorting pathway|ciliary basal body|negative regulation of protein catabolic process|protein complex|early endosome to late endosome transport|positive regulation of protein catabolic process|protein dimerization activity|dynein light intermediate chain binding|cilium assembly|intralumenal vesicle formation hsa04145,hsa05132 Phagosome|Salmonella infection RILPL1 333.907022246564 345.532453994389 322.28159049874 0.932710044376827 -0.100499440986093 0.605808621341745 1 1.9765 2.25835 2.14689 1.94764 GeneID:353116,Genbank:NM_178314.4,HGNC:HGNC:26814,MIM:614092 Rab interacting lysosomal protein like 1 GO:0003382,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0005929,GO:0031267,GO:0036064,GO:0046983,GO:0051959,GO:0060271,GO:1901214,GO:1903445 epithelial cell morphogenesis|nucleoplasm|cytoplasm|centrosome|cytosol|plasma membrane|cilium|small GTPase binding|ciliary basal body|protein dimerization activity|dynein light intermediate chain binding|cilium assembly|regulation of neuron death|protein transport from ciliary membrane to plasma membrane RILPL2 278.851111833719 282.458338966799 275.243884700639 0.974458342095513 -0.0373275830181762 0.871048100226809 1 3.7896 3.61263 3.22434 3.79169 GeneID:196383,Genbank:XM_011538012.3,HGNC:HGNC:28787,MIM:614093 Rab interacting lysosomal protein like 2 GO:0003382,GO:0005737,GO:0005813,GO:0005829,GO:0005929,GO:0016020,GO:0031267,GO:0036064,GO:0042802,GO:0046983,GO:0051959,GO:0060271,GO:0070062,GO:1903445 epithelial cell morphogenesis|cytoplasm|centrosome|cytosol|cilium|membrane|small GTPase binding|ciliary basal body|identical protein binding|protein dimerization activity|dynein light intermediate chain binding|cilium assembly|extracellular exosome|protein transport from ciliary membrane to plasma membrane RIMBP2 1.07619535328461 2.15239070656922 0 0 -Inf 0.475634333897108 1 0.00802311 0 0 0 GeneID:23504,Genbank:XM_017019106.2,HGNC:HGNC:30339,MIM:611602 RIMS binding protein 2 GO:0005886,GO:0010923,GO:0030054,GO:0045202 plasma membrane|negative regulation of phosphatase activity|cell junction|synapse RIMBP3 6.91615740975802 6.07296192222811 7.75935289728793 1.27768838281158 0.353536018295168 0.863543298564463 1 0.0346659 0.0599411 0.112209 0.0149765 GeneID:85376,Genbank:NM_015672.1,HGNC:HGNC:29344,MIM:612699 RIMS binding protein 3 GO:0005737,GO:0005856,GO:0007283,GO:0030154 cytoplasm|cytoskeleton|spermatogenesis|cell differentiation RIMBP3B 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0079777 0 0.00797361 GeneID:440804,Genbank:NM_001128635.1,HGNC:HGNC:33891,MIM:612700 RIMS binding protein 3B GO:0005737,GO:0005856 cytoplasm|cytoskeleton RIMBP3C 0.974269732491135 0.980142803914724 0.968396661067546 0.988015886256305 -0.0173938558720137 1 1 0 0.00747394 0 0.0149342 GeneID:150221,Genbank:NM_001128633.1,HGNC:HGNC:33892,MIM:612701 RIMS binding protein 3C GO:0005737,GO:0005856 cytoplasm|cytoskeleton RIMKLA 55.297605861341 53.8970285593471 56.6981831633349 1.05197233834335 0.0730967694025104 0.84224264793978 1 0.219163 0.152305 0.191315 0.211933 GeneID:284716,Genbank:NM_173642.3,HGNC:HGNC:28725 ribosomal modification protein rimK like family member A GO:0005524,GO:0005737,GO:0005829,GO:0006464,GO:0008652,GO:0046872,GO:0072590 ATP binding|cytoplasm|cytosol|cellular protein modification process|cellular amino acid biosynthetic process|metal ion binding|N-acetyl-L-aspartate-L-glutamate ligase activity hsa00250 Alanine, aspartate and glutamate metabolism RIMKLB 215.044505546992 230.415734810803 199.673276283181 0.866578302246308 -0.206597980633384 0.357413128639644 1 0.893727 0.995794 0.918648 0.796776 GeneID:57494,Genbank:XM_017019684.1,HGNC:HGNC:29228,MIM:614054 ribosomal modification protein rimK like family member B GO:0005524,GO:0005737,GO:0005829,GO:0006464,GO:0008652,GO:0046872,GO:0072590,GO:0072591 ATP binding|cytoplasm|cytosol|cellular protein modification process|cellular amino acid biosynthetic process|metal ion binding|N-acetyl-L-aspartate-L-glutamate ligase activity|citrate-L-glutamate ligase activity hsa00250 Alanine, aspartate and glutamate metabolism RIMS1 3.53512121627662 4.16070258908361 2.90953984346962 0.699290511920596 -0.516036164271094 0.844311129886097 1 0.0116636 0.00837791 0.0140424 0.00261394 GeneID:22999,Genbank:NM_014989.5,HGNC:HGNC:17282,MIM:606629 regulating synaptic membrane exocytosis 1 GO:0003723,GO:0005829,GO:0005886,GO:0006461,GO:0006886,GO:0007269,GO:0007601,GO:0010628,GO:0014047,GO:0016079,GO:0017137,GO:0017156,GO:0030054,GO:0030695,GO:0042391,GO:0042734,GO:0044325,GO:0045055,GO:0046872,GO:0046903,GO:0046928,GO:0048786,GO:0048791,GO:0050896,GO:0061025,GO:0097151,GO:1903861,GO:2000300,GO:2000463 RNA binding|cytosol|plasma membrane|protein complex assembly|intracellular protein transport|neurotransmitter secretion|visual perception|positive regulation of gene expression|glutamate secretion|synaptic vesicle exocytosis|Rab GTPase binding|calcium ion regulated exocytosis|cell junction|GTPase regulator activity|regulation of membrane potential|presynaptic membrane|ion channel binding|regulated exocytosis|metal ion binding|secretion|regulation of neurotransmitter secretion|presynaptic active zone|calcium ion-regulated exocytosis of neurotransmitter|response to stimulus|membrane fusion|positive regulation of inhibitory postsynaptic potential|positive regulation of dendrite extension|regulation of synaptic vesicle exocytosis|positive regulation of excitatory postsynaptic potential hsa04721,hsa04723 Synaptic vesicle cycle|Retrograde endocannabinoid signaling RIMS2 23.0566654018916 21.3896368967453 24.7236939070379 1.15587253894899 0.20898231690027 0.778252000404532 1 0.0873505 0.0379754 0.104821 0.0422143 GeneID:9699,Genbank:XM_017014034.2,HGNC:HGNC:17283,MIM:606630 regulating synaptic membrane exocytosis 2 GO:0005622,GO:0006886,GO:0010628,GO:0017137,GO:0017156,GO:0017157,GO:0019933,GO:0030054,GO:0030073,GO:0042391,GO:0042734,GO:0044325,GO:0046872,GO:0048786,GO:0048791,GO:0061669,GO:0070062,GO:0097151,GO:1903861,GO:2000300,GO:2000463 intracellular|intracellular protein transport|positive regulation of gene expression|Rab GTPase binding|calcium ion regulated exocytosis|regulation of exocytosis|cAMP-mediated signaling|cell junction|insulin secretion|regulation of membrane potential|presynaptic membrane|ion channel binding|metal ion binding|presynaptic active zone|calcium ion-regulated exocytosis of neurotransmitter|spontaneous neurotransmitter secretion|extracellular exosome|positive regulation of inhibitory postsynaptic potential|positive regulation of dendrite extension|regulation of synaptic vesicle exocytosis|positive regulation of excitatory postsynaptic potential hsa04911 Insulin secretion RIMS3 308.934931961875 288.839075847352 329.030788076398 1.13914915117055 0.187956654479318 0.351302988428229 1 1.52702 1.6448 1.66941 1.93385 GeneID:9783,Genbank:XM_011542479.2,HGNC:HGNC:21292,MIM:611600 regulating synaptic membrane exocytosis 3 GO:0017156,GO:0030054,GO:0042391,GO:0044325,GO:0048786,GO:0048791,GO:2000300 calcium ion regulated exocytosis|cell junction|regulation of membrane potential|ion channel binding|presynaptic active zone|calcium ion-regulated exocytosis of neurotransmitter|regulation of synaptic vesicle exocytosis RIMS4 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00869467 0 0 0 GeneID:140730,Genbank:NM_182970.3,HGNC:HGNC:16183,MIM:611601 regulating synaptic membrane exocytosis 4 GO:0030054,GO:0042391,GO:0044325,GO:0048786,GO:0048791,GO:0097060,GO:2000300 cell junction|regulation of membrane potential|ion channel binding|presynaptic active zone|calcium ion-regulated exocytosis of neurotransmitter|synaptic membrane|regulation of synaptic vesicle exocytosis RIN1 229.928203153211 258.734014919852 201.122391386569 0.777332626515576 -0.363396024004707 0.0905944641319135 0.979717040875575 3.29337 3.57111 2.7132 2.61707 GeneID:9610,Genbank:XM_011545400.2,HGNC:HGNC:18749,MIM:605965 Ras and Rab interactor 1 GO:0005096,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006897,GO:0007165,GO:0017112 GTPase activator activity|cytoplasm|cytosol|cytoskeleton|plasma membrane|endocytosis|signal transduction|Rab guanyl-nucleotide exchange factor activity hsa04014 Ras signaling pathway RIN2 301.308769082937 284.706782222738 317.910755943135 1.11662515891322 0.159144967258466 0.42088973197588 1 1.11533 1.04875 1.19082 1.1471 GeneID:54453,Genbank:XM_005260731.2,HGNC:HGNC:18750,MIM:610222 Ras and Rab interactor 2 GO:0005096,GO:0005829,GO:0006897,GO:0007264,GO:0017112,GO:0030695 GTPase activator activity|cytosol|endocytosis|small GTPase mediated signal transduction|Rab guanyl-nucleotide exchange factor activity|GTPase regulator activity RIN3 394.723630481235 400.29497249892 389.152288463551 0.972163817182594 -0.0407286552091817 0.811258653028568 1 2.70456 2.91839 2.75373 2.69923 GeneID:79890,Genbank:XM_017021652.1,HGNC:HGNC:18751,MIM:610223 Ras and Rab interactor 3 GO:0005096,GO:0005769,GO:0005829,GO:0006897,GO:0007165,GO:0017112,GO:0017137,GO:0031410 GTPase activator activity|early endosome|cytosol|endocytosis|signal transduction|Rab guanyl-nucleotide exchange factor activity|Rab GTPase binding|cytoplasmic vesicle RING1 1751.56465754046 1700.38298459746 1802.74633048345 1.06020017067521 0.0843366779740927 0.567412862236533 1 32.9402 34.442 35.5731 36.8229 GeneID:6015,Genbank:NM_002931.3,HGNC:HGNC:10018,MIM:602045 ring finger protein 1 GO:0001739,GO:0003682,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0009952,GO:0016607,GO:0016740,GO:0031519,GO:0035102,GO:0035518,GO:0045892,GO:0046872,GO:0048593,GO:0070317,GO:0097027 sex chromatin|chromatin binding|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|anterior/posterior pattern specification|nuclear speck|transferase activity|PcG protein complex|PRC1 complex|histone H2A monoubiquitination|negative regulation of transcription, DNA-templated|metal ion binding|camera-type eye morphogenesis|negative regulation of G0 to G1 transition|ubiquitin-protein transferase activator activity RINL 4.9249213890126 5.48683797090087 4.36300480712434 0.795176535240021 -0.330652909657594 0.852750925961322 1 0.012696 0.101429 0.0710402 0.0332963 GeneID:126432,Genbank:XM_011526455.3,HGNC:HGNC:24795 Ras and Rab interactor like GO:0001726,GO:0005085,GO:0005096,GO:0006897,GO:0015031,GO:0015629,GO:0031410 ruffle|guanyl-nucleotide exchange factor activity|GTPase activator activity|endocytosis|protein transport|actin cytoskeleton|cytoplasmic vesicle RINT1 603.09651505976 653.175522558898 553.017507560622 0.846659876956358 -0.240145573236315 0.157939626051568 1 7.55164 7.01247 7.05138 5.33867 GeneID:60561,Genbank:NM_021930.5,HGNC:HGNC:21876,MIM:610089 RAD50 interactor 1 GO:0005783,GO:0005789,GO:0005829,GO:0006890,GO:0007049,GO:0015031,GO:0060628,GO:0070939,GO:1902504 endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|retrograde vesicle-mediated transport, Golgi to ER|cell cycle|protein transport|regulation of ER to Golgi vesicle-mediated transport|Dsl1/NZR complex|regulation of signal transduction involved in mitotic G2 DNA damage checkpoint RIOK1 367.717622588925 355.95822360444 379.47702157341 1.06607179272561 0.0923045971229758 0.6303034580285 1 2.99192 3.40252 3.64377 3.3515 GeneID:83732,Genbank:NM_001348194.1,HGNC:HGNC:18656,MIM:617753 RIO kinase 1 GO:0004674,GO:0005524,GO:0005654,GO:0005829,GO:0006364,GO:0016787,GO:0030490,GO:0030688,GO:0042274,GO:0046872,GO:2000234 protein serine/threonine kinase activity|ATP binding|nucleoplasm|cytosol|rRNA processing|hydrolase activity|maturation of SSU-rRNA|preribosome, small subunit precursor|ribosomal small subunit biogenesis|metal ion binding|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes RIOK2 210.849691473081 231.722252882404 189.977130063758 0.819848450895947 -0.286570842897326 0.210999787751791 1 1.66118 1.51956 1.37748 1.20157 GeneID:55781,Genbank:NM_018343.2,HGNC:HGNC:18999,MIM:617754 RIO kinase 2 GO:0004674,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006364,GO:0030071,GO:0030490,GO:0030688,GO:0042274,GO:0046777,GO:0046872,GO:2000208,GO:2000234 protein serine/threonine kinase activity|ATP binding|nucleoplasm|cytoplasm|cytosol|rRNA processing|regulation of mitotic metaphase/anaphase transition|maturation of SSU-rRNA|preribosome, small subunit precursor|ribosomal small subunit biogenesis|protein autophosphorylation|metal ion binding|positive regulation of ribosomal small subunit export from nucleus|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes RIOK3 320.903693045707 310.305147983252 331.502238108163 1.06831046878428 0.0953309791264254 0.61543904369828 1 3.0169 2.72812 3.35168 2.85345 GeneID:8780,Genbank:XM_011526243.1,HGNC:HGNC:11451,MIM:603579 RIO kinase 3 GO:0004674,GO:0005524,GO:0005829,GO:0006364,GO:0007059,GO:0030490,GO:0030688,GO:0032463,GO:0032728,GO:0039534,GO:0043124,GO:0045087,GO:0045089,GO:0046872,GO:0051607,GO:0071359,GO:0089720,GO:0098586,GO:1990786 protein serine/threonine kinase activity|ATP binding|cytosol|rRNA processing|chromosome segregation|maturation of SSU-rRNA|preribosome, small subunit precursor|negative regulation of protein homooligomerization|positive regulation of interferon-beta production|negative regulation of MDA-5 signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|positive regulation of innate immune response|metal ion binding|defense response to virus|cellular response to dsRNA|caspase binding|cellular response to virus|cellular response to dsDNA RIOX2 467.238343744715 501.208412679995 433.268274809435 0.864447331386001 -0.210150028142951 0.243811555214296 1 2.62473 2.50974 2.44395 2.12325 GeneID:84864,Genbank:NM_001261829.1,HGNC:HGNC:19441,MIM:612049 ribosomal oxygenase 2 RIPK1 1257.08946796344 1277.37122281912 1236.80771310776 0.968244540829852 -0.0465566328345184 0.758549011721677 1 7.36639 7.06324 7.27888 6.46576 GeneID:8737,Genbank:NM_001317061.2,HGNC:HGNC:10019,MIM:603453 receptor interacting serine/threonine kinase 1 hsa04064,hsa04210,hsa04217,hsa04620,hsa04621,hsa04622,hsa04623,hsa04668,hsa05160,hsa05163,hsa05169,hsa05170 NF-kappa B signaling pathway|Apoptosis|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|TNF signaling pathway|Hepatitis C|Human cytomegalovirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection RIPK2 269.59431523107 289.597687587203 249.590942874937 0.861854060211651 -0.214484499858477 0.31056224660901 1 3.82199 3.4855 3.60262 3.33449 GeneID:8767,Genbank:NM_003821.5,HGNC:HGNC:10020,MIM:603455 receptor interacting serine/threonine kinase 2 GO:0000165,GO:0000187,GO:0001961,GO:0002250,GO:0004674,GO:0004715,GO:0004871,GO:0005102,GO:0005524,GO:0005737,GO:0005829,GO:0005856,GO:0006915,GO:0006954,GO:0007165,GO:0007249,GO:0007254,GO:0010800,GO:0010942,GO:0016579,GO:0030274,GO:0031398,GO:0031663,GO:0031982,GO:0032092,GO:0032722,GO:0032727,GO:0032728,GO:0032729,GO:0032735,GO:0032743,GO:0032755,GO:0032760,GO:0033091,GO:0033138,GO:0034134,GO:0034142,GO:0042098,GO:0042802,GO:0042803,GO:0043065,GO:0043066,GO:0043123,GO:0043234,GO:0043330,GO:0045087,GO:0045627,GO:0045944,GO:0046330,GO:0046641,GO:0050700,GO:0050718,GO:0050731,GO:0050830,GO:0050852,GO:0051092,GO:0070374,GO:0070423,GO:0070427,GO:0070431,GO:0070498,GO:0070671,GO:0070673,GO:0071223,GO:0071224,GO:0071225,GO:0089720,GO:0097202,GO:1904417 MAPK cascade|activation of MAPK activity|positive regulation of cytokine-mediated signaling pathway|adaptive immune response|protein serine/threonine kinase activity|non-membrane spanning protein tyrosine kinase activity|signal transducer activity|receptor binding|ATP binding|cytoplasm|cytosol|cytoskeleton|apoptotic process|inflammatory response|signal transduction|I-kappaB kinase/NF-kappaB signaling|JNK cascade|positive regulation of peptidyl-threonine phosphorylation|positive regulation of cell death|protein deubiquitination|LIM domain binding|positive regulation of protein ubiquitination|lipopolysaccharide-mediated signaling pathway|vesicle|positive regulation of protein binding|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-12 production|positive regulation of interleukin-2 production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of immature T cell proliferation|positive regulation of peptidyl-serine phosphorylation|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway|T cell proliferation|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|protein complex|response to exogenous dsRNA|innate immune response|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|positive regulation of alpha-beta T cell proliferation|CARD domain binding|positive regulation of interleukin-1 beta secretion|positive regulation of peptidyl-tyrosine phosphorylation|defense response to Gram-positive bacterium|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of ERK1 and ERK2 cascade|nucleotide-binding oligomerization domain containing signaling pathway|nucleotide-binding oligomerization domain containing 1 signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|interleukin-1-mediated signaling pathway|response to interleukin-12|response to interleukin-18|cellular response to lipoteichoic acid|cellular response to peptidoglycan|cellular response to muramyl dipeptide|caspase binding|activation of cysteine-type endopeptidase activity|positive regulation of xenophagy hsa04621,hsa04722,hsa05131,hsa05152 NOD-like receptor signaling pathway|Neurotrophin signaling pathway|Shigellosis|Tuberculosis RIPK4 5.96165932081747 4.65077399104097 7.27254465059396 1.56372781489779 0.644989416564407 0.637464706789406 1 0.0700885 0.0485479 0.142877 0.0484029 GeneID:54101,Genbank:NM_020639.2,HGNC:HGNC:496,MIM:605706 receptor interacting serine/threonine kinase 4 GO:0002009,GO:0004674,GO:0005524,GO:0005737,GO:0016020,GO:0051092 morphogenesis of an epithelium|protein serine/threonine kinase activity|ATP binding|cytoplasm|membrane|positive regulation of NF-kappaB transcription factor activity RIPOR1 1610.15111508409 1605.57970695733 1614.72252321085 1.0056944019745 0.00819198333983581 0.969663033215017 1 9.98885 10.0712 10.4111 10.4794 GeneID:79567,Genbank:XM_024450442.1,HGNC:HGNC:25836 RHO family interacting cell polarization regulator 1 GO:0005737,GO:0005794,GO:0007266,GO:0009267,GO:0009611,GO:0012506,GO:0016020,GO:0030335,GO:0031252,GO:0034067,GO:0035024,GO:0051683,GO:0070062,GO:0071889,GO:0090316,GO:1990869,GO:2001107 cytoplasm|Golgi apparatus|Rho protein signal transduction|cellular response to starvation|response to wounding|vesicle membrane|membrane|positive regulation of cell migration|cell leading edge|protein localization to Golgi apparatus|negative regulation of Rho protein signal transduction|establishment of Golgi localization|extracellular exosome|14-3-3 protein binding|positive regulation of intracellular protein transport|cellular response to chemokine|negative regulation of Rho guanyl-nucleotide exchange factor activity RIPOR2 1192.03621307172 1239.38680184073 1144.68562430271 0.923590296913471 -0.11467507841062 0.442627545667117 1 4.31205 4.35192 4.09642 3.90937 GeneID:9750,Genbank:NM_001286445.2,HGNC:HGNC:13872,MIM:611410 RHO family interacting cell polarization regulator 2 GO:0005737,GO:0005856,GO:0006935,GO:0007155,GO:0007162,GO:0007605,GO:0016324,GO:0030175,GO:0032420,GO:0035024,GO:0042130,GO:0042802,GO:0045184,GO:0045663,GO:0048741,GO:0051260,GO:0051491,GO:0060088,GO:0060171,GO:0071158,GO:0071260,GO:0071889,GO:0090023,GO:1901673,GO:1901741,GO:1903904,GO:1905872,GO:1990869,GO:2000114,GO:2000391,GO:2000405,GO:2001107 cytoplasm|cytoskeleton|chemotaxis|cell adhesion|negative regulation of cell adhesion|sensory perception of sound|apical plasma membrane|filopodium|stereocilium|negative regulation of Rho protein signal transduction|negative regulation of T cell proliferation|identical protein binding|establishment of protein localization|positive regulation of myoblast differentiation|skeletal muscle fiber development|protein homooligomerization|positive regulation of filopodium assembly|auditory receptor cell stereocilium organization|stereocilium membrane|positive regulation of cell cycle arrest|cellular response to mechanical stimulus|14-3-3 protein binding|positive regulation of neutrophil chemotaxis|regulation of mitotic spindle assembly|positive regulation of myoblast fusion|negative regulation of establishment of T cell polarity|negative regulation of protein localization to cell leading edge|cellular response to chemokine|regulation of establishment of cell polarity|positive regulation of neutrophil extravasation|negative regulation of T cell migration|negative regulation of Rho guanyl-nucleotide exchange factor activity RIPOR3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00601963 GeneID:140876,Genbank:XM_005260294.3,HGNC:HGNC:16168 RIPOR family member 3 RIPPLY1 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0657226 GeneID:92129,Genbank:NM_001171706.1,HGNC:HGNC:25117,MIM:300575 ripply transcriptional repressor 1 GO:0000122,GO:0001757,GO:0005634,GO:0006351,GO:0009880,GO:0032525,GO:0045892 negative regulation of transcription from RNA polymerase II promoter|somite specification|nucleus|transcription, DNA-templated|embryonic pattern specification|somite rostral/caudal axis specification|negative regulation of transcription, DNA-templated RIPPLY2 3.73332723417535 5.04479284362845 2.42186162472226 0.480071570784331 -1.05867859089014 0.544932688080261 1 0.186344 0.164477 0.0871474 0.0807638 GeneID:134701,Genbank:NM_001009994.2,HGNC:HGNC:21390,MIM:609891 ripply transcriptional repressor 2 GO:0000122,GO:0001503,GO:0001756,GO:0005634,GO:0007219,GO:0007368,GO:0009880,GO:0032525,GO:0036342,GO:0060349 negative regulation of transcription from RNA polymerase II promoter|ossification|somitogenesis|nucleus|Notch signaling pathway|determination of left/right symmetry|embryonic pattern specification|somite rostral/caudal axis specification|post-anal tail morphogenesis|bone morphogenesis RIT1 609.05520880514 555.624938606623 662.485479003657 1.19232495334895 0.253777477994096 0.12841250648248 1 5.50891 5.86176 7.09185 6.34895 GeneID:6016,Genbank:NM_001256820.1,HGNC:HGNC:10023,MIM:609591 Ras like without CAAX 1 GO:0003924,GO:0005516,GO:0005525,GO:0005622,GO:0005886,GO:0007165,GO:0007265 GTPase activity|calmodulin binding|GTP binding|intracellular|plasma membrane|signal transduction|Ras protein signal transduction RIT2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0435193 0 0 GeneID:6014,Genbank:NM_002930.3,HGNC:HGNC:10017,MIM:609592 Ras like without CAAX 2 GO:0003682,GO:0003924,GO:0005516,GO:0005525,GO:0005634,GO:0005737,GO:0005886,GO:0007189,GO:0007264,GO:0007265,GO:0007268,GO:0010976,GO:0010977,GO:0030100,GO:0030215,GO:0032489,GO:0032507,GO:0035556,GO:0043005,GO:0043410,GO:0044297,GO:0045121,GO:0045944,GO:0050848,GO:0097447 chromatin binding|GTPase activity|calmodulin binding|GTP binding|nucleus|cytoplasm|plasma membrane|adenylate cyclase-activating G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|Ras protein signal transduction|chemical synaptic transmission|positive regulation of neuron projection development|negative regulation of neuron projection development|regulation of endocytosis|semaphorin receptor binding|regulation of Cdc42 protein signal transduction|maintenance of protein location in cell|intracellular signal transduction|neuron projection|positive regulation of MAPK cascade|cell body|membrane raft|positive regulation of transcription from RNA polymerase II promoter|regulation of calcium-mediated signaling|dendritic tree RITA1 682.301949061811 741.839211692749 622.764686430873 0.839487420744223 -0.252419387552211 0.12063870841632 1 14.7664 14.3739 13.1615 11.6105 GeneID:84934,Genbank:NM_032848.2,HGNC:HGNC:25925 RBPJ interacting and tubulin associated 1 GO:0000122,GO:0005634,GO:0005737,GO:0005813,GO:0007219,GO:0015631,GO:0022008,GO:0045746,GO:0051168 negative regulation of transcription from RNA polymerase II promoter|nucleus|cytoplasm|centrosome|Notch signaling pathway|tubulin binding|neurogenesis|negative regulation of Notch signaling pathway|nuclear export RLBP1 1.29177983152393 1.61429302992691 0.969266633120943 0.600427936658332 -0.735936990778882 0.974657200381333 1 0.033476 0 0.0105259 0.0098423 GeneID:6017,Genbank:NM_000326.4,HGNC:HGNC:10024,MIM:180090 retinaldehyde binding protein 1 RLF 162.087880466981 175.365058658163 148.8107022758 0.848576697173611 -0.236883033668177 0.505180455806816 1 1.00492 0.845152 0.960472 0.582769 GeneID:6018,Genbank:NM_012421.3,HGNC:HGNC:10025,MIM:180610 rearranged L-myc fusion GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270,GO:0015074,GO:0044030,GO:0045893,GO:0045944,GO:0051276,GO:0097692 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|DNA integration|regulation of DNA methylation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|chromosome organization|histone H3-K4 monomethylation RLIM 823.032340180698 822.515645569517 823.549034791879 1.0012563763716 0.00181143027981735 0.986104742065546 1 3.43026 3.21657 4.22316 2.54074 GeneID:51132,Genbank:NM_016120.3,HGNC:HGNC:13429,MIM:300379 ring finger protein, LIM domain interacting GO:0000122,GO:0000209,GO:0003714,GO:0004842,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006511,GO:0016567,GO:0017053,GO:0043161,GO:0043433,GO:0045892,GO:0046872,GO:0060816,GO:0061630,GO:1900095 negative regulation of transcription from RNA polymerase II promoter|protein polyubiquitination|transcription corepressor activity|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|ubiquitin-dependent protein catabolic process|protein ubiquitination|transcriptional repressor complex|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of DNA binding transcription factor activity|negative regulation of transcription, DNA-templated|metal ion binding|random inactivation of X chromosome|ubiquitin protein ligase activity|regulation of dosage compensation by inactivation of X chromosome RLN1 2.29386920912273 3.13253351048394 1.45520490776151 0.464545679365038 -1.10610762927358 0.696563168601363 1 0.0503434 0.0343321 0.0112368 2.82184e-08 GeneID:6013,Genbank:XM_024447637.1,HGNC:HGNC:10026,MIM:179730 relaxin 1 GO:0005179,GO:0005576,GO:0007165,GO:0007565 hormone activity|extracellular region|signal transduction|female pregnancy hsa04926 Relaxin signaling pathway RMC1 360.042669141827 371.640508467076 348.444829816578 0.937585709517583 -0.0929775142112813 0.617567433063892 1 5.86732 6.49596 5.87507 5.60148 GeneID:29919,Genbank:NM_013326.4,HGNC:HGNC:24326 regulator of MON1-CCZ1 GO:0005765,GO:0006914,GO:0010506,GO:0031902,GO:0035658 lysosomal membrane|autophagy|regulation of autophagy|late endosome membrane|Mon1-Ccz1 complex RMDN1 593.582011163913 573.593884344775 613.570137983052 1.06969435122891 0.0971986275060452 0.564755528907253 1 2.35649 2.43047 2.83738 2.21797 GeneID:51115,Genbank:XM_017013525.2,HGNC:HGNC:24285,MIM:611871 regulator of microtubule dynamics 1 GO:0000922,GO:0005739,GO:0005874 spindle pole|mitochondrion|microtubule RMDN2 33.5041486349462 31.6331100631649 35.3751872067275 1.11829621355884 0.161302378905477 0.780820996269947 1 0.0961717 0.163813 0.133419 0.16236 GeneID:151393,Genbank:XM_011532618.2,HGNC:HGNC:26567,MIM:611872 regulator of microtubule dynamics 2 GO:0000922,GO:0005794,GO:0005829,GO:0005874,GO:0016021,GO:0072686 spindle pole|Golgi apparatus|cytosol|microtubule|integral component of membrane|mitotic spindle RMDN3 1406.80829531813 1275.42176286725 1538.19482776901 1.20602836845988 0.270263843021606 0.0665650163627972 0.910422973583741 9.28586 10.5528 12.7436 12.1828 GeneID:55177,Genbank:NM_001323894.1,HGNC:HGNC:25550,MIM:611873 regulator of microtubule dynamics 3 GO:0000922,GO:0005634,GO:0005739,GO:0005741,GO:0005874,GO:0006874,GO:0006915,GO:0016021,GO:0030154 spindle pole|nucleus|mitochondrion|mitochondrial outer membrane|microtubule|cellular calcium ion homeostasis|apoptotic process|integral component of membrane|cell differentiation RMI1 144.980426690714 142.617535622136 147.343317759291 1.03313605242539 0.0470302534621834 0.851694528525419 1 1.43087 1.21856 1.8461 1.21149 GeneID:80010,Genbank:NM_001358294.1,HGNC:HGNC:25764,MIM:610404 RecQ mediated genome instability 1 GO:0000166,GO:0000731,GO:0000732,GO:0005654,GO:0006260,GO:0016604,GO:1901796 nucleotide binding|DNA synthesis involved in DNA repair|strand displacement|nucleoplasm|DNA replication|nuclear body|regulation of signal transduction by p53 class mediator hsa03460 Fanconi anemia pathway RMI2 143.650483009721 135.132194423829 152.168771595614 1.12607341458803 0.171300887284424 0.506800091508156 1 5.71491 5.22178 6.31728 6.35921 GeneID:116028,Genbank:NM_152308.2,HGNC:HGNC:28349,MIM:612426 RecQ mediated genome instability 2 GO:0000731,GO:0000732,GO:0003677,GO:0005654,GO:0005829,GO:0006260,GO:0016607,GO:0033045,GO:1901796 DNA synthesis involved in DNA repair|strand displacement|DNA binding|nucleoplasm|cytosol|DNA replication|nuclear speck|regulation of sister chromatid segregation|regulation of signal transduction by p53 class mediator hsa03460 Fanconi anemia pathway RMND1 353.058877741827 363.971853824282 342.145901659372 0.940033956099675 -0.0892152238291976 0.657548571975799 1 5.674 5.48678 5.2867 4.9016 GeneID:55005,Genbank:XM_005267040.4,HGNC:HGNC:21176,MIM:614917 required for meiotic nuclear division 1 homolog GO:0005739,GO:0006412,GO:0070131 mitochondrion|translation|positive regulation of mitochondrial translation RMND5A 536.917372096389 662.823063118882 411.011681073896 0.620092606826172 -0.689444406110476 6.68464589776352e-05 0.0187826822278212 4.99768 4.6869 3.53811 2.59375 GeneID:64795,Genbank:NM_022780.3,HGNC:HGNC:25850 required for meiotic nuclear division 5 homolog A GO:0005634,GO:0005737,GO:0034657,GO:0042787,GO:0043161 nucleus|cytoplasm|GID complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process RMND5B 607.078259479202 578.351536541149 635.804982417256 1.09934000732446 0.136637656548463 0.449149218791273 1 6.98234 7.84095 8.42624 8.82873 GeneID:64777,Genbank:XM_024446169.1,HGNC:HGNC:26181 required for meiotic nuclear division 5 homolog B GO:0005634,GO:0005737,GO:0034657,GO:0042787,GO:0043161 nucleus|cytoplasm|GID complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process RNASE4 97.0538487649245 72.9519783058914 121.155719223958 1.66075988667429 0.731843502954045 0.0151971741147189 0.511744031201217 1.9254 1.92297 3.16019 3.12546 GeneID:6038,Genbank:NM_001282192.1,HGNC:HGNC:10047,MIM:601030 ribonuclease A family member 4 GO:0003676,GO:0004519,GO:0004522,GO:0004540,GO:0005576,GO:0006379,GO:0070062 nucleic acid binding|endonuclease activity|ribonuclease A activity|ribonuclease activity|extracellular region|mRNA cleavage|extracellular exosome RNASE7 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0292241 0 GeneID:84659,Genbank:NM_032572.3,HGNC:HGNC:19278,MIM:612484 ribonuclease A family member 7 GO:0001530,GO:0003676,GO:0004519,GO:0004540,GO:0005576,GO:0005615,GO:0005737,GO:0019730,GO:0019731,GO:0042834,GO:0045087,GO:0050829,GO:0050830,GO:0050832,GO:0051673,GO:0061844,GO:0070062 lipopolysaccharide binding|nucleic acid binding|endonuclease activity|ribonuclease activity|extracellular region|extracellular space|cytoplasm|antimicrobial humoral response|antibacterial humoral response|peptidoglycan binding|innate immune response|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|defense response to fungus|membrane disruption in other organism|antimicrobial humoral immune response mediated by antimicrobial peptide|extracellular exosome RNASEH1 1951.43997211352 2076.40267571512 1826.47726851193 0.879635385695546 -0.185022453244912 0.19375211080782 1 17.3759 17.0275 14.4673 15.4959 GeneID:246243,Genbank:NM_002936.5,HGNC:HGNC:18466,MIM:604123 ribonuclease H1 hsa03030 DNA replication RNASEH2A 2185.9251110929 2199.9977385586 2171.85248362721 0.987206689153316 -0.0185759248979839 0.919273250995309 1 63.1411 67.1986 59.4568 71.8499 GeneID:10535,Genbank:XM_006722619.2,HGNC:HGNC:18518,MIM:606034 ribonuclease H2 subunit A GO:0003723,GO:0004523,GO:0004540,GO:0005654,GO:0005829,GO:0006260,GO:0006298,GO:0006401,GO:0032299,GO:0043137,GO:0046872 RNA binding|RNA-DNA hybrid ribonuclease activity|ribonuclease activity|nucleoplasm|cytosol|DNA replication|mismatch repair|RNA catabolic process|ribonuclease H2 complex|DNA replication, removal of RNA primer|metal ion binding hsa03030 DNA replication RNASEH2B 477.555549745435 513.114205151026 441.996894339844 0.861400619789409 -0.215243733268602 0.227050538451717 1 2.69689 2.69274 2.35759 2.23517 GeneID:79621,Genbank:NM_001142279.2,HGNC:HGNC:25671,MIM:610326 ribonuclease H2 subunit B GO:0001701,GO:0004523,GO:0005634,GO:0005654,GO:0006401,GO:0009259,GO:0010389,GO:0010629,GO:0032299,GO:0048146,GO:2000001 in utero embryonic development|RNA-DNA hybrid ribonuclease activity|nucleus|nucleoplasm|RNA catabolic process|ribonucleotide metabolic process|regulation of G2/M transition of mitotic cell cycle|negative regulation of gene expression|ribonuclease H2 complex|positive regulation of fibroblast proliferation|regulation of DNA damage checkpoint hsa03030 DNA replication RNASEH2C 1348.88789476001 1341.35107941318 1356.42471010683 1.0112376475667 0.0161220800069365 0.956250028326201 1 16.2641 19.9599 19.5073 19.4672 GeneID:84153,Genbank:NM_032193.3,HGNC:HGNC:24116,MIM:610330 ribonuclease H2 subunit C GO:0005634,GO:0006401,GO:0032299 nucleus|RNA catabolic process|ribonuclease H2 complex hsa03030 DNA replication RNASEK 4741.48384510252 4465.75601252457 5017.21167768047 1.12348539947308 0.167981375746429 0.208427504094262 1 391.266 377.9 429.26 442.329 GeneID:440400,Genbank:NM_001004333.4,HGNC:HGNC:33911,MIM:617098 ribonuclease K GO:0004521,GO:0016021 endoribonuclease activity|integral component of membrane RNASEL 210.73130871906 195.130593869873 226.332023568247 1.15990024464939 0.214000734026901 0.397765296829757 1 1.85832 1.34486 2.02752 1.77209 GeneID:6041,Genbank:NM_021133.3,HGNC:HGNC:10050,MIM:180435 ribonuclease L GO:0003723,GO:0004521,GO:0004672,GO:0005524,GO:0005759,GO:0005829,GO:0006364,GO:0006397,GO:0006468,GO:0016363,GO:0019843,GO:0042802,GO:0043021,GO:0043488,GO:0045071,GO:0045444,GO:0045944,GO:0046872,GO:0051607,GO:0060337,GO:0060338,GO:2001275 RNA binding|endoribonuclease activity|protein kinase activity|ATP binding|mitochondrial matrix|cytosol|rRNA processing|mRNA processing|protein phosphorylation|nuclear matrix|rRNA binding|identical protein binding|ribonucleoprotein complex binding|regulation of mRNA stability|negative regulation of viral genome replication|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|defense response to virus|type I interferon signaling pathway|regulation of type I interferon-mediated signaling pathway|positive regulation of glucose import in response to insulin stimulus hsa04621,hsa05160,hsa05164,hsa05168 NOD-like receptor signaling pathway|Hepatitis C|Influenza A|Herpes simplex infection RNASET2 409.51376577193 390.185769501447 428.841762042413 1.09907073902351 0.136284244844098 0.560304071194666 1 10.8674 10.9738 10.6164 13.82 GeneID:8635,Genbank:XM_024446575.1,HGNC:HGNC:21686,MIM:612944 ribonuclease T2 RND1 25.2672080631464 27.760565122191 22.7738510041019 0.82036698114251 -0.285658668769982 0.639975747868493 1 0.651809 0.539688 0.4458 0.548832 GeneID:27289,Genbank:NM_014470.3,HGNC:HGNC:18314,MIM:609038 Rho family GTPase 1 GO:0003924,GO:0005102,GO:0005525,GO:0005829,GO:0005886,GO:0005912,GO:0007015,GO:0007162,GO:0007264,GO:0015629,GO:0016322,GO:0043231 GTPase activity|receptor binding|GTP binding|cytosol|plasma membrane|adherens junction|actin filament organization|negative regulation of cell adhesion|small GTPase mediated signal transduction|actin cytoskeleton|neuron remodeling|intracellular membrane-bounded organelle hsa04360 Axon guidance RND2 22.6030065192271 23.3979487792597 21.8080642591945 0.932050260684626 -0.10152034077459 0.930835938129145 1 0.243278 0.128751 0.1341 0.160689 GeneID:8153,Genbank:NM_005440.4,HGNC:HGNC:18315,MIM:601555 Rho family GTPase 2 GO:0002080,GO:0003924,GO:0005525,GO:0005769,GO:0007165,GO:0007264,GO:0047485,GO:0048672 acrosomal membrane|GTPase activity|GTP binding|early endosome|signal transduction|small GTPase mediated signal transduction|protein N-terminus binding|positive regulation of collateral sprouting RND3 590.67362828457 580.348005766845 600.999250802295 1.03558424398851 0.0504449204737118 0.786289113589637 1 8.5734 7.47308 9.65484 7.19761 GeneID:390,Genbank:NM_001254738.1,HGNC:HGNC:671,MIM:602924 Rho family GTPase 3 RNF10 4298.45999465687 4288.15435326729 4308.76563604645 1.00480656270301 0.00691779206129247 0.976856399338192 1 31.6965 35.2561 34.4136 34.4014 GeneID:9921,Genbank:NM_014868.4,HGNC:HGNC:10055,MIM:615998 ring finger protein 10 GO:0004842,GO:0005634,GO:0005737,GO:0006351,GO:0010626,GO:0031643,GO:0044212,GO:0045893,GO:0045944,GO:0046872,GO:0051865 ubiquitin-protein transferase activity|nucleus|cytoplasm|transcription, DNA-templated|negative regulation of Schwann cell proliferation|positive regulation of myelination|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|protein autoubiquitination RNF103 330.907159422908 340.96792389761 320.846394948207 0.940987032682156 -0.087753252926164 0.662619728599852 1 3.50209 3.50094 3.65498 2.94757 GeneID:7844,Genbank:NM_001198951.1,HGNC:HGNC:12859,MIM:602507 ring finger protein 103 GO:0004842,GO:0005783,GO:0005789,GO:0007417,GO:0016021,GO:0016567,GO:0030433,GO:0044322,GO:0046872,GO:1904264,GO:1904380 ubiquitin-protein transferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|central nervous system development|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|endoplasmic reticulum quality control compartment|metal ion binding|ubiquitin protein ligase activity involved in ERAD pathway|endoplasmic reticulum mannose trimming RNF103-CHMP3 1.78228621950799 2.59443583384164 0.97013660517434 0.373929696976871 -1.41916104230609 0.670772680940795 1 4.95619e-06 0.162656 3.28666e-06 5.04788e-06 GeneID:100526767,Genbank:NM_001198954.1,HGNC:HGNC:38847 RNF103-CHMP3 readthrough GO:0000815,GO:0000920,GO:0005622,GO:0005770,GO:0005829,GO:0005886,GO:0006915,GO:0007049,GO:0010824,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0031210,GO:0031410,GO:0031902,GO:0036258,GO:0039702,GO:0042802,GO:0042803,GO:0050792,GO:0051258,GO:0051291,GO:0061763,GO:0070062,GO:0071985,GO:0097352,GO:1902187,GO:1902188,GO:1990381,GO:2000641 ESCRT III complex|cell separation after cytokinesis|intracellular|late endosome|cytosol|plasma membrane|apoptotic process|cell cycle|regulation of centrosome duplication|protein transport|endosomal transport|macroautophagy|viral life cycle|phosphatidylcholine binding|cytoplasmic vesicle|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|identical protein binding|protein homodimerization activity|regulation of viral process|protein polymerization|protein heterooligomerization|multivesicular body-lysosome fusion|extracellular exosome|multivesicular body sorting pathway|autophagosome maturation|negative regulation of viral release from host cell|positive regulation of viral release from host cell|ubiquitin-specific protease binding|regulation of early endosome to late endosome transport hsa04144,hsa04217 Endocytosis|Necroptosis RNF11 2617.29497913101 2869.13084397057 2365.45911429145 0.824451460365574 -0.278493537490576 0.0444669303394695 0.785206567052859 47.005 46.2179 39.739 37.9149 GeneID:26994,Genbank:NM_014372.4,HGNC:HGNC:10056,MIM:612598 ring finger protein 11 GO:0000151,GO:0003677,GO:0004842,GO:0005634,GO:0005769,GO:0008270,GO:0042787,GO:0043161,GO:0051865,GO:0055037,GO:0061630,GO:0070062 ubiquitin ligase complex|DNA binding|ubiquitin-protein transferase activity|nucleus|early endosome|zinc ion binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein autoubiquitination|recycling endosome|ubiquitin protein ligase activity|extracellular exosome RNF111 566.623178476734 627.759453242016 505.486903711453 0.805223881696889 -0.312538133886507 0.0693156516160982 0.918407228165493 3.37357 3.0197 2.69527 2.43479 GeneID:54778,Genbank:NM_001330331.1,HGNC:HGNC:17384,MIM:605840 ring finger protein 111 GO:0005737,GO:0006281,GO:0007275,GO:0016567,GO:0016605,GO:0016740,GO:0032184,GO:0046872 cytoplasm|DNA repair|multicellular organism development|protein ubiquitination|PML body|transferase activity|SUMO polymer binding|metal ion binding RNF112 29.3537548431746 20.4193027479385 38.2882069384107 1.87509864617078 0.906966495660675 0.0880679937927114 0.970748099507272 0.0949348 0.111472 0.194832 0.166374 GeneID:7732,Genbank:XM_006721571.4,HGNC:HGNC:12968,MIM:601237 ring finger protein 112 GO:0003924,GO:0005525,GO:0005634,GO:0005737,GO:0008270,GO:0016021,GO:0045666,GO:0045687,GO:0071158 GTPase activity|GTP binding|nucleus|cytoplasm|zinc ion binding|integral component of membrane|positive regulation of neuron differentiation|positive regulation of glial cell differentiation|positive regulation of cell cycle arrest RNF113A 475.117874915621 486.469070002552 463.766679828689 0.953332305024565 -0.0689489098749329 0.683758344012752 1 15.2292 16.7788 14.7259 15.7746 GeneID:7737,Genbank:NM_006978.2,HGNC:HGNC:12974,MIM:300951 ring finger protein 113A GO:0005684,GO:0034247,GO:0045292,GO:0046872 U2-type spliceosomal complex|snoRNA splicing|mRNA cis splicing, via spliceosome|metal ion binding RNF114 1938.82804510266 1943.50235823957 1934.15373196575 0.995189804512357 -0.00695638941764779 0.94453889044434 1 35.7751 39.4738 38.81 36.9063 GeneID:55905,Genbank:NM_018683.3,HGNC:HGNC:13094,MIM:612451 ring finger protein 114 GO:0000209,GO:0004842,GO:0005622,GO:0005634,GO:0005829,GO:0005886,GO:0007275,GO:0007283,GO:0030154,GO:0031624,GO:0032436,GO:0046872,GO:0061630 protein polyubiquitination|ubiquitin-protein transferase activity|intracellular|nucleus|cytosol|plasma membrane|multicellular organism development|spermatogenesis|cell differentiation|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity RNF115 1698.08824497664 1719.34086479378 1676.8356251595 0.975278177524515 -0.0361143190047347 0.796847656969351 1 17.0637 17.6727 17.8134 15.9867 GeneID:27246,Genbank:XM_005272952.5,HGNC:HGNC:18154 ring finger protein 115 GO:0000209,GO:0004842,GO:0005829,GO:0042059,GO:0042787,GO:0043161,GO:0043162,GO:0046872,GO:0051865,GO:0061630,GO:0070534,GO:0070936 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|negative regulation of epidermal growth factor receptor signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination RNF121 706.155340858827 678.582800221527 733.727881496127 1.08126507370449 0.112720245218382 0.493725305151568 1 8.35926 8.61623 9.52539 8.85988 GeneID:55298,Genbank:XM_006718629.1,HGNC:HGNC:21070 ring finger protein 121 GO:0000139,GO:0005789,GO:0016021,GO:0030433,GO:0030968,GO:0046872,GO:0061630 Golgi membrane|endoplasmic reticulum membrane|integral component of membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|metal ion binding|ubiquitin protein ligase activity RNF122 79.8351415954124 74.8642376390359 84.8060455517888 1.13279782478636 0.179890400253757 0.596336425916068 1 1.24096 1.44158 1.65978 1.67399 GeneID:79845,Genbank:NM_024787.3,HGNC:HGNC:21147 ring finger protein 122 GO:0000209,GO:0005783,GO:0005794,GO:0016021,GO:0042787,GO:0043161,GO:0046872,GO:0061630 protein polyubiquitination|endoplasmic reticulum|Golgi apparatus|integral component of membrane|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity RNF123 1535.16251083652 1441.55291712823 1628.77210454481 1.12987326735777 0.176160961305912 0.229074835598968 1 11.6803 12.1847 13.404 14.1577 GeneID:63891,Genbank:XM_017007018.1,HGNC:HGNC:21148,MIM:614472 ring finger protein 123 GO:0005737,GO:0005829,GO:0016567,GO:0016579,GO:0016740,GO:0031965,GO:0046872 cytoplasm|cytosol|protein ubiquitination|protein deubiquitination|transferase activity|nuclear membrane|metal ion binding RNF126 1513.31275678702 1575.22572300215 1451.39979057189 0.921391626214513 -0.118113608377507 0.395830982104437 1 42.4871 44.6802 40.5702 43.2045 GeneID:55658,Genbank:XM_005259594.2,HGNC:HGNC:21151,MIM:615177 ring finger protein 126 GO:0000209,GO:0005154,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006513,GO:0042059,GO:0042127,GO:0042147,GO:0042787,GO:0043161,GO:0043162,GO:0046872,GO:0061630,GO:0070534,GO:0070936,GO:0071629 protein polyubiquitination|epidermal growth factor receptor binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein monoubiquitination|negative regulation of epidermal growth factor receptor signaling pathway|regulation of cell proliferation|retrograde transport, endosome to Golgi|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|metal ion binding|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|cytoplasm protein quality control by the ubiquitin-proteasome system RNF13 209.107469392323 224.371181853044 193.843756931601 0.863942309037542 -0.210993117272109 0.369974905520374 1 2.13791 1.74331 1.70162 1.90738 GeneID:11342,Genbank:NM_007282.4,HGNC:HGNC:10057,MIM:609247 ring finger protein 13 GO:0000139,GO:0004842,GO:0005637,GO:0005654,GO:0005765,GO:0005789,GO:0005829,GO:0016021,GO:0031902,GO:0043231,GO:0046872,GO:0051865,GO:0061630 Golgi membrane|ubiquitin-protein transferase activity|nuclear inner membrane|nucleoplasm|lysosomal membrane|endoplasmic reticulum membrane|cytosol|integral component of membrane|late endosome membrane|intracellular membrane-bounded organelle|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity RNF130 1931.90266333997 1786.72956988961 2077.07575679034 1.16250147296698 0.217232544212766 0.12636567817151 1 4.32828 4.47139 5.26861 5.19555 GeneID:55819,Genbank:XM_011534593.3,HGNC:HGNC:18280 ring finger protein 130 GO:0004842,GO:0005737,GO:0006915,GO:0012501,GO:0016021,GO:0046872 ubiquitin-protein transferase activity|cytoplasm|apoptotic process|programmed cell death|integral component of membrane|metal ion binding RNF133 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0290535 0 0 GeneID:168433,Genbank:NM_139175.1,HGNC:HGNC:21154 ring finger protein 133 GO:0005789,GO:0016021,GO:0016740,GO:0046872,GO:0051865 endoplasmic reticulum membrane|integral component of membrane|transferase activity|metal ion binding|protein autoubiquitination RNF135 352.202519760613 314.774642531515 389.630396989711 1.237807448072 0.307786907995509 0.15483431789781 1 2.87783 3.70878 3.97625 3.81212 GeneID:84282,Genbank:XM_017025223.1,HGNC:HGNC:21158,MIM:611358 ring finger protein 135 RNF138 177.410632339678 201.155529517416 153.665735161939 0.763915043899573 -0.388515891914144 0.39837585817748 1 2.95238 2.24291 2.7045 1.28925 GeneID:51444,Genbank:NM_016271.4,HGNC:HGNC:17765,MIM:616319 ring finger protein 138 GO:0000209,GO:0000724,GO:0003697,GO:0005634,GO:0010792,GO:0016055,GO:0016567,GO:0019901,GO:0031624,GO:0032436,GO:0035861,GO:0046872,GO:0061630,GO:1990830 protein polyubiquitination|double-strand break repair via homologous recombination|single-stranded DNA binding|nucleus|DNA double-strand break processing involved in repair via single-strand annealing|Wnt signaling pathway|protein ubiquitination|protein kinase binding|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|site of double-strand break|metal ion binding|ubiquitin protein ligase activity|cellular response to leukemia inhibitory factor RNF139 755.148243012948 786.722849918124 723.573636107772 0.919731308405592 -0.120715643117841 0.454727364326635 1 11.587 12.055 11.5995 10.2883 GeneID:11236,Genbank:NM_007218.3,HGNC:HGNC:17023,MIM:603046 ring finger protein 139 RNF14 1662.21091002586 1599.56356296404 1724.85825708768 1.07833055029802 0.108799488087271 0.449604845715996 1 12.9281 13.5439 15.5921 13.5027 GeneID:9604,Genbank:XM_024446265.1,HGNC:HGNC:10058,MIM:605675 ring finger protein 14 GO:0000151,GO:0000209,GO:0003713,GO:0005634,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0006357,GO:0007165,GO:0016567,GO:0019787,GO:0030521,GO:0031624,GO:0032436,GO:0042787,GO:0045893,GO:0046872,GO:0050681,GO:0060765,GO:0061630 ubiquitin ligase complex|protein polyubiquitination|transcription coactivator activity|nucleus|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|signal transduction|protein ubiquitination|ubiquitin-like protein transferase activity|androgen receptor signaling pathway|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|metal ion binding|androgen receptor binding|regulation of androgen receptor signaling pathway|ubiquitin protein ligase activity RNF141 265.454496531647 287.157139232525 243.751853830769 0.848844832770784 -0.236427238931606 0.260827719992756 1 3.11703 3.06152 2.47774 2.81352 GeneID:50862,Genbank:NM_016422.3,HGNC:HGNC:21159,MIM:616641 ring finger protein 141 GO:0003677,GO:0004842,GO:0006355,GO:0016020,GO:0046872,GO:0051865 DNA binding|ubiquitin-protein transferase activity|regulation of transcription, DNA-templated|membrane|metal ion binding|protein autoubiquitination RNF144A 243.475833659988 221.854198259211 265.097469060765 1.1949175230438 0.256911042304682 0.233428818215929 1 0.354614 0.402605 0.476752 0.427388 GeneID:9781,Genbank:NM_001349185.1,HGNC:HGNC:20457 ring finger protein 144A GO:0000151,GO:0000209,GO:0005794,GO:0005886,GO:0010008,GO:0016021,GO:0016567,GO:0030659,GO:0031624,GO:0032436,GO:0042787,GO:0043231,GO:0046872,GO:0061630 ubiquitin ligase complex|protein polyubiquitination|Golgi apparatus|plasma membrane|endosome membrane|integral component of membrane|protein ubiquitination|cytoplasmic vesicle membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|metal ion binding|ubiquitin protein ligase activity RNF144B 85.8751708865612 84.021706797063 87.7286349760594 1.04411869646911 0.0622857282616895 0.867798103781307 1 0.720112 0.753861 0.943917 0.686071 GeneID:255488,Genbank:XM_005248986.3,HGNC:HGNC:21578 ring finger protein 144B GO:0000151,GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0006915,GO:0016021,GO:0031624,GO:0031966,GO:0032436,GO:0042787,GO:0043066,GO:0046872,GO:0061630 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|apoptotic process|integral component of membrane|ubiquitin conjugating enzyme binding|mitochondrial membrane|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of apoptotic process|metal ion binding|ubiquitin protein ligase activity RNF145 4175.3712808983 4476.1100705463 3874.6324912503 0.865624935531893 -0.208186036284033 0.125837597919792 1 44.3474 41.4131 38.3106 35.9183 GeneID:153830,Genbank:NM_001199380.1,HGNC:HGNC:20853 ring finger protein 145 GO:0000209,GO:0008270,GO:0016021,GO:0042787,GO:0043161,GO:0061630 protein polyubiquitination|zinc ion binding|integral component of membrane|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity RNF146 501.061458458573 526.691108580923 475.431808336223 0.902676731371431 -0.14771867589388 0.421322810069185 1 1.94329 1.70419 1.78078 1.58984 GeneID:81847,Genbank:XM_017011339.2,HGNC:HGNC:21336,MIM:612137 ring finger protein 146 GO:0004842,GO:0005654,GO:0005829,GO:0005886,GO:0008270,GO:0016055,GO:0016579,GO:0042787,GO:0051865,GO:0061630,GO:0070936,GO:0072572,GO:0090263 ubiquitin-protein transferase activity|nucleoplasm|cytosol|plasma membrane|zinc ion binding|Wnt signaling pathway|protein deubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein autoubiquitination|ubiquitin protein ligase activity|protein K48-linked ubiquitination|poly-ADP-D-ribose binding|positive regulation of canonical Wnt signaling pathway RNF148 1.48378615844747 1.02816907859967 1.93940323829528 1.88626878464064 0.915535268080234 0.868235938463046 1 0.0325372 0.0308558 0.0931008 0.028884 GeneID:378925,Genbank:NM_198085.1,HGNC:HGNC:22411 ring finger protein 148 GO:0016021,GO:0046872 integral component of membrane|metal ion binding RNF149 604.905727840236 630.17260963308 579.638846047392 0.919809647685081 -0.120592764972921 0.46163630433991 1 2.25141 2.61663 2.32563 2.13009 GeneID:284996,Genbank:XM_005263921.4,HGNC:HGNC:23137 ring finger protein 149 GO:0016020,GO:0016021,GO:0031647,GO:0035690,GO:0043409,GO:0046872,GO:0061630,GO:0070062 membrane|integral component of membrane|regulation of protein stability|cellular response to drug|negative regulation of MAPK cascade|metal ion binding|ubiquitin protein ligase activity|extracellular exosome RNF150 279.636633834171 279.123891702467 280.149375965875 1.00367393940072 0.00529066130955509 0.977803027645545 1 0.982396 0.910151 1.11954 0.812845 GeneID:57484,Genbank:XM_011532148.3,HGNC:HGNC:23138 ring finger protein 150 GO:0016021,GO:0046872 integral component of membrane|metal ion binding RNF151 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0 0 GeneID:146310,Genbank:XM_005255129.4,HGNC:HGNC:23235 ring finger protein 151 GO:0005634,GO:0005737,GO:0007283,GO:0008270,GO:0030154 nucleus|cytoplasm|spermatogenesis|zinc ion binding|cell differentiation RNF152 15.6228672936576 16.7006452861273 14.5450893011879 0.870929778579877 -0.199371693145434 0.823931158557965 1 0.0574605 0.099708 0.105733 0.0280568 GeneID:220441,Genbank:XM_005266652.3,HGNC:HGNC:26811,MIM:616512 ring finger protein 152 GO:0004842,GO:0005764,GO:0005765,GO:0006915,GO:0010508,GO:0016567,GO:0031267,GO:0031301,GO:0034198,GO:0046872,GO:0061630,GO:0070534,GO:0070936,GO:1904262 ubiquitin-protein transferase activity|lysosome|lysosomal membrane|apoptotic process|positive regulation of autophagy|protein ubiquitination|small GTPase binding|integral component of organelle membrane|cellular response to amino acid starvation|metal ion binding|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|negative regulation of TORC1 signaling hsa04150 mTOR signaling pathway RNF157 1036.06447412781 927.938831920143 1144.19011633548 1.23304476219393 0.302225173644257 0.0496435944553466 0.815111977981293 3.3541 3.70458 4.58976 4.3318 GeneID:114804,Genbank:NM_001330501.1,HGNC:HGNC:29402 ring finger protein 157 GO:0005737,GO:0016740,GO:0046872 cytoplasm|transferase activity|metal ion binding RNF165 1.72838687339946 1.51824048055703 1.93853326624189 1.27682886279692 0.352565169253837 1 1 0.0039623 0.00724178 0.00748779 0.00699962 GeneID:494470,Genbank:XM_011526016.3,HGNC:HGNC:31696 ring finger protein 165 GO:0000209,GO:0005634,GO:0005737,GO:0008045,GO:0008270,GO:0010259,GO:0030513,GO:0035136,GO:0042787,GO:0043161,GO:0043234,GO:0060384,GO:0061061,GO:0061630 protein polyubiquitination|nucleus|cytoplasm|motor neuron axon guidance|zinc ion binding|multicellular organism aging|positive regulation of BMP signaling pathway|forelimb morphogenesis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein complex|innervation|muscle structure development|ubiquitin protein ligase activity RNF166 556.946006902206 568.722596290525 545.169417513887 0.958585822103319 -0.061020492852973 0.711138330505842 1 3.95247 3.87628 3.45339 4.50575 GeneID:115992,Genbank:NM_178841.3,HGNC:HGNC:28856,MIM:617178 ring finger protein 166 GO:0000209,GO:0005622,GO:0031624,GO:0032436,GO:0046872,GO:0061630 protein polyubiquitination|intracellular|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity RNF167 3474.54447186917 3355.55595570185 3593.53298803648 1.07092029919223 0.0988511147858949 0.480876791874481 1 38.0724 40.9214 44.4926 41.8886 GeneID:26001,Genbank:NM_015528.2,HGNC:HGNC:24544,MIM:610431 ring finger protein 167 GO:0000209,GO:0004842,GO:0005737,GO:0008270,GO:0012505,GO:0016021,GO:0045786 protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|zinc ion binding|endomembrane system|integral component of membrane|negative regulation of cell cycle RNF168 577.770014635481 648.111112405054 507.428916865908 0.782935066462458 -0.353035433829778 0.0400402540093007 0.758464027333929 4.92518 4.19713 3.84647 3.28267 GeneID:165918,Genbank:NM_152617.3,HGNC:HGNC:26661,MIM:612688 ring finger protein 168 GO:0000151,GO:0003682,GO:0004842,GO:0005634,GO:0005654,GO:0005829,GO:0006302,GO:0006303,GO:0006511,GO:0006974,GO:0010212,GO:0016567,GO:0031491,GO:0034244,GO:0035518,GO:0035861,GO:0036297,GO:0036351,GO:0036352,GO:0042393,GO:0043130,GO:0043234,GO:0045190,GO:0045739,GO:0046872,GO:0070530,GO:0070534,GO:0070535 ubiquitin ligase complex|chromatin binding|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|response to ionizing radiation|protein ubiquitination|nucleosome binding|negative regulation of transcription elongation from RNA polymerase II promoter|histone H2A monoubiquitination|site of double-strand break|interstrand cross-link repair|histone H2A-K13 ubiquitination|histone H2A-K15 ubiquitination|histone binding|ubiquitin binding|protein complex|isotype switching|positive regulation of DNA repair|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked ubiquitination|histone H2A K63-linked ubiquitination RNF169 382.081082472731 440.382740908344 323.779424037118 0.735222782276352 -0.443746622917827 0.0676999989698885 0.916343630061028 2.50835 2.15365 2.04595 1.43475 GeneID:254225,Genbank:XM_011544889.3,HGNC:HGNC:26961 ring finger protein 169 GO:0005634,GO:0005654,GO:0006974,GO:0016567,GO:0016607,GO:0016740,GO:0031491,GO:0035861,GO:0046872,GO:0070530,GO:2000780 nucleus|nucleoplasm|cellular response to DNA damage stimulus|protein ubiquitination|nuclear speck|transferase activity|nucleosome binding|site of double-strand break|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|negative regulation of double-strand break repair RNF17 7.90293489067464 9.50346173592965 6.30240804541962 0.663169718629178 -0.592549962270986 0.617932196911644 1 0.0176771 0.0510486 0.0341157 0.0158514 GeneID:56163,Genbank:XM_011535156.2,HGNC:HGNC:10060,MIM:605793 ring finger protein 17 GO:0005634,GO:0005737,GO:0007275,GO:0007286,GO:0042803,GO:0046872 nucleus|cytoplasm|multicellular organism development|spermatid development|protein homodimerization activity|metal ion binding RNF170 251.285367947573 251.997476806288 250.573259088858 0.994348285802383 -0.00817682842105794 0.993744602522902 1 1.63404 1.47317 1.80485 1.31584 GeneID:81790,Genbank:NM_001160224.1,HGNC:HGNC:25358,MIM:614649 ring finger protein 170 GO:0005789,GO:0016021,GO:0016567,GO:0016740,GO:0046872 endoplasmic reticulum membrane|integral component of membrane|protein ubiquitination|transferase activity|metal ion binding RNF180 17.1121774031234 14.8364122276678 19.3879425785791 1.30678106546698 0.3860174561889 0.605234995545221 1 0.0346882 0.0521698 0.0668984 0.0553871 GeneID:285671,Genbank:XM_017009388.1,HGNC:HGNC:27752,MIM:616015 ring finger protein 180 GO:0000209,GO:0005622,GO:0005635,GO:0005789,GO:0016021,GO:0030534,GO:0031624,GO:0032436,GO:0042415,GO:0042428,GO:0046872,GO:0061630 protein polyubiquitination|intracellular|nuclear envelope|endoplasmic reticulum membrane|integral component of membrane|adult behavior|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|norepinephrine metabolic process|serotonin metabolic process|metal ion binding|ubiquitin protein ligase activity RNF181 1162.55966116592 1126.2696028854 1198.84971944644 1.06444293300209 0.0900986059839221 0.643630659383376 1 9.74947 10.6121 9.84525 11.9267 GeneID:51255,Genbank:XM_005264359.4,HGNC:HGNC:28037,MIM:612490 ring finger protein 181 GO:0000209,GO:0004842,GO:0005737,GO:0016567,GO:0042787,GO:0043161,GO:0046872,GO:0051865,GO:0061630 protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|protein ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity RNF182 901.67425122595 838.304808637485 965.043693814416 1.15118472883738 0.203119359094331 0.425252076215399 1 9.96694 10.888 14.6189 9.75485 GeneID:221687,Genbank:NM_001165034.1,HGNC:HGNC:28522 ring finger protein 182 GO:0004842,GO:0005737,GO:0016021,GO:0016567,GO:0046872 ubiquitin-protein transferase activity|cytoplasm|integral component of membrane|protein ubiquitination|metal ion binding RNF185 1098.97654654464 1048.91577361615 1149.03731947314 1.09545241703424 0.131526819609161 0.381105106510849 1 12.4891 12.479 13.9164 13.8392 GeneID:91445,Genbank:NM_152267.3,HGNC:HGNC:26783 ring finger protein 185 GO:0005741,GO:0005783,GO:0005789,GO:0006914,GO:0016021,GO:0030433,GO:0036503,GO:0042787,GO:0044322,GO:0044390,GO:0046872,GO:0051865,GO:0055085,GO:0071712,GO:1904264,GO:1904380 mitochondrial outer membrane|endoplasmic reticulum|endoplasmic reticulum membrane|autophagy|integral component of membrane|ubiquitin-dependent ERAD pathway|ERAD pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|endoplasmic reticulum quality control compartment|ubiquitin-like protein conjugating enzyme binding|metal ion binding|protein autoubiquitination|transmembrane transport|ER-associated misfolded protein catabolic process|ubiquitin protein ligase activity involved in ERAD pathway|endoplasmic reticulum mannose trimming hsa04141 Protein processing in endoplasmic reticulum RNF187 3326.2925457817 3102.87528539401 3549.70980616938 1.14400660022616 0.194095375618123 0.158188658892001 1 44.7512 47.2732 51.951 54.3544 GeneID:149603,Genbank:NM_001010858.2,HGNC:HGNC:27146,MIM:613754 ring finger protein 187 GO:0004842,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0008284,GO:0043161,GO:0045893,GO:0046872,GO:0051865,GO:0070936 ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytoplasm|cytosol|positive regulation of cell proliferation|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|metal ion binding|protein autoubiquitination|protein K48-linked ubiquitination RNF19A 830.442778117846 879.58444225978 781.301113975912 0.888261634060552 -0.17094341542144 0.28426878222917 1 5.29789 5.02413 5.17184 3.95803 GeneID:25897,Genbank:NM_001280539.1,HGNC:HGNC:13432,MIM:607119 ring finger protein 19A, RBR E3 ubiquitin protein ligase GO:0000151,GO:0000209,GO:0000226,GO:0004842,GO:0005737,GO:0005813,GO:0005829,GO:0008134,GO:0016021,GO:0031624,GO:0032436,GO:0042787,GO:0046872,GO:0061630 ubiquitin ligase complex|protein polyubiquitination|microtubule cytoskeleton organization|ubiquitin-protein transferase activity|cytoplasm|centrosome|cytosol|transcription factor binding|integral component of membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity RNF19B 880.467524463971 878.903282759938 882.031766168005 1.00355953091703 0.00512619957187694 0.989467149430671 1 5.81249 6.08955 6.32582 5.84249 GeneID:127544,Genbank:XM_006710356.2,HGNC:HGNC:26886,MIM:610872 ring finger protein 19B GO:0000151,GO:0000209,GO:0002250,GO:0004842,GO:0005789,GO:0005829,GO:0016021,GO:0031624,GO:0032436,GO:0042787,GO:0044194,GO:0046872,GO:0061630 ubiquitin ligase complex|protein polyubiquitination|adaptive immune response|ubiquitin-protein transferase activity|endoplasmic reticulum membrane|cytosol|integral component of membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|cytolytic granule|metal ion binding|ubiquitin protein ligase activity RNF2 270.57123028677 298.803183019915 242.339277553624 0.811033119207007 -0.302167265598813 0.148589049992208 1 2.29597 2.44389 2.21066 1.68715 GeneID:6045,Genbank:NM_007212.3,HGNC:HGNC:10061,MIM:608985 ring finger protein 2 GO:0000122,GO:0000151,GO:0000278,GO:0000791,GO:0001702,GO:0001739,GO:0003682,GO:0005634,GO:0005654,GO:0006351,GO:0007281,GO:0008270,GO:0009948,GO:0016604,GO:0031519,GO:0035102,GO:0035518,GO:0036353,GO:0043433,GO:0061630,GO:0070317,GO:0071339,GO:0071535 negative regulation of transcription from RNA polymerase II promoter|ubiquitin ligase complex|mitotic cell cycle|euchromatin|gastrulation with mouth forming second|sex chromatin|chromatin binding|nucleus|nucleoplasm|transcription, DNA-templated|germ cell development|zinc ion binding|anterior/posterior axis specification|nuclear body|PcG protein complex|PRC1 complex|histone H2A monoubiquitination|histone H2A-K119 monoubiquitination|negative regulation of DNA binding transcription factor activity|ubiquitin protein ligase activity|negative regulation of G0 to G1 transition|MLL1 complex|RING-like zinc finger domain binding RNF20 630.514034984826 652.78150370631 608.246566263341 0.931776655450388 -0.101943908986869 0.55764881594565 1 4.6194 4.28342 4.59142 3.74839 GeneID:56254,Genbank:NM_019592.6,HGNC:HGNC:10062,MIM:607699 ring finger protein 20 GO:0000151,GO:0000209,GO:0002039,GO:0003682,GO:0003713,GO:0003730,GO:0004842,GO:0005634,GO:0005654,GO:0005730,GO:0006355,GO:0006511,GO:0010390,GO:0016567,GO:0030336,GO:0031062,GO:0031625,GO:0033503,GO:0033523,GO:0042393,GO:0045893,GO:0046872,GO:1900364,GO:2001168 ubiquitin ligase complex|protein polyubiquitination|p53 binding|chromatin binding|transcription coactivator activity|mRNA 3'-UTR binding|ubiquitin-protein transferase activity|nucleus|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|histone monoubiquitination|protein ubiquitination|negative regulation of cell migration|positive regulation of histone methylation|ubiquitin protein ligase binding|HULC complex|histone H2B ubiquitination|histone binding|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of mRNA polyadenylation|positive regulation of histone H2B ubiquitination RNF207 1.56333021953018 2.64246210852658 0.484198330533773 0.183237568089012 -2.44821277409849 0.497207036451224 1 0.0118418 0 0 0.0102792 GeneID:388591,Genbank:XM_011541439.3,HGNC:HGNC:32947,MIM:616923 ring finger protein 207 GO:0008270,GO:0010628,GO:0030544,GO:0044325,GO:0048471,GO:0051087,GO:0055117,GO:0086019,GO:1901207,GO:1902261,GO:1903762,GO:1903954 zinc ion binding|positive regulation of gene expression|Hsp70 protein binding|ion channel binding|perinuclear region of cytoplasm|chaperone binding|regulation of cardiac muscle contraction|cell-cell signaling involved in cardiac conduction|regulation of heart looping|positive regulation of delayed rectifier potassium channel activity|positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization RNF208 32.9747281779842 27.1744411708637 38.7750151851047 1.4268928270245 0.51287697901357 0.307803826520378 1 1.47889 1.39971 2.14831 1.69269 GeneID:727800,Genbank:NM_031297.4,HGNC:HGNC:25420 ring finger protein 208 GO:0004842,GO:0005654,GO:0005829,GO:0046872,GO:0051865 ubiquitin-protein transferase activity|nucleoplasm|cytosol|metal ion binding|protein autoubiquitination RNF212B 0.968396661067546 0 1.93679332213509 Inf Inf 0.496080204589898 1 0 0 0 0.0538334 GeneID:100507650,Genbank:XM_011536327.2,HGNC:HGNC:20438 ring finger protein 212B GO:0000795,GO:0007129,GO:0016925,GO:0019789,GO:0046872 synaptonemal complex|synapsis|protein sumoylation|SUMO transferase activity|metal ion binding RNF213 4307.05719538806 4184.25144139893 4429.86294937719 1.05869903169494 0.0822925164373567 0.79666952634878 1 5.51666 5.86961 7.59872 4.69127 GeneID:57674,Genbank:XM_005257545.4,HGNC:HGNC:14539,MIM:613768 ring finger protein 213 RNF214 404.433717302906 419.70470647762 389.162728128192 0.927229840699782 -0.109001098067527 0.558399123110578 1 4.40685 4.53161 4.45836 4.06465 GeneID:257160,Genbank:NM_207343.3,HGNC:HGNC:25335 ring finger protein 214 GO:0046872 metal ion binding RNF215 309.198315761987 317.963993970938 300.432637553036 0.94486370548137 -0.081821856143358 0.700770280268032 1 7.31935 7.46536 5.92068 7.88856 GeneID:200312,Genbank:NM_001017981.1,HGNC:HGNC:33434 ring finger protein 215 GO:0016021,GO:0046872 integral component of membrane|metal ion binding RNF216 2602.40957738982 2454.56901688765 2750.25013789198 1.12046152256058 0.16409310653312 0.235930092994999 1 11.6495 12.0076 13.63 13.2818 GeneID:54476,Genbank:NM_207116.2,HGNC:HGNC:21698,MIM:609948 ring finger protein 216 GO:0005634,GO:0005654,GO:0005829,GO:0006915,GO:0016032,GO:0032480,GO:0032648,GO:0043161,GO:0046872,GO:0050691,GO:0061630,GO:0070936 nucleus|nucleoplasm|cytosol|apoptotic process|viral process|negative regulation of type I interferon production|regulation of interferon-beta production|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|regulation of defense response to virus by host|ubiquitin protein ligase activity|protein K48-linked ubiquitination RNF217 408.691564249308 437.884357623872 379.498770874745 0.866664369867081 -0.206454700835614 0.289306474452963 1 1.30356 1.15471 1.17886 0.944458 GeneID:154214,Genbank:XM_011535495.3,HGNC:HGNC:21487 ring finger protein 217 GO:0000151,GO:0000209,GO:0004842,GO:0005737,GO:0005829,GO:0016021,GO:0031624,GO:0032436,GO:0042787,GO:0046872,GO:0061630 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|cytosol|integral component of membrane|ubiquitin conjugating enzyme binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity RNF219 131.655768871787 130.509829397257 132.801708346317 1.01756096808681 0.0251152374609421 0.918769198511128 1 1.58793 1.07302 1.58461 1.12365 GeneID:79596,Genbank:NM_024546.3,HGNC:HGNC:20308,MIM:615906 ring finger protein 219 GO:0046872 metal ion binding RNF220 2163.12397646685 2191.55085486573 2134.69709806796 0.974057751536295 -0.0379207831700691 0.771256274421658 1 12.929 13.9875 13.1079 13.2699 GeneID:55182,Genbank:NM_018150.3,HGNC:HGNC:25552,MIM:616136 ring finger protein 220 GO:0004842,GO:0005737,GO:0016567,GO:0046872,GO:0051865,GO:0061630,GO:0090263 ubiquitin-protein transferase activity|cytoplasm|protein ubiquitination|metal ion binding|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of canonical Wnt signaling pathway RNF222 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0285278 0 0 0 GeneID:643904,Genbank:NM_001146684.2,HGNC:HGNC:34517 ring finger protein 222 GO:0016021,GO:0016567,GO:0033234,GO:0033768,GO:0043161,GO:0046872,GO:0061630 integral component of membrane|protein ubiquitination|negative regulation of protein sumoylation|SUMO-targeted ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity RNF225 1.27070322989325 2.05633815719933 0.48506830258717 0.235889365223771 -2.08381771694066 0.63179572723844 1 0 0.236897 0 0 GeneID:646862,Genbank:NM_001195135.1,HGNC:HGNC:51249 ring finger protein 225 GO:0016021,GO:0046872 integral component of membrane|metal ion binding RNF227 78.8652121285293 75.3445003858853 82.3859238711734 1.09345636973136 0.128895656208617 0.690873014415624 1 1.67985 1.25284 1.67632 1.56173 GeneID:284023,Genbank:NM_001358699.1,HGNC:HGNC:27571 ring finger protein 227 RNF24 994.736725922221 917.867846542247 1071.6056053022 1.16749443761333 0.223415676404498 0.146570813416906 1 4.4304 4.67355 6.16277 4.81651 GeneID:11237,Genbank:NM_001134337.2,HGNC:HGNC:13779,MIM:612489 ring finger protein 24 GO:0000139,GO:0000209,GO:0005794,GO:0008270,GO:0016021,GO:0042787,GO:0043161,GO:0061630 Golgi membrane|protein polyubiquitination|Golgi apparatus|zinc ion binding|integral component of membrane|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity RNF25 633.043462079801 642.385160061583 623.701764098018 0.970915585967501 -0.0425822256074852 0.803317077607619 1 11.7552 11.1793 10.9782 11.0145 GeneID:64320,Genbank:NM_022453.2,HGNC:HGNC:14662,MIM:616014 ring finger protein 25 GO:0004842,GO:0005634,GO:0005829,GO:0016567,GO:0046872,GO:0051059,GO:0051092,GO:0061630 ubiquitin-protein transferase activity|nucleus|cytosol|protein ubiquitination|metal ion binding|NF-kappaB binding|positive regulation of NF-kappaB transcription factor activity|ubiquitin protein ligase activity RNF26 1645.14119685302 1546.06055325728 1744.22184044877 1.12817175030693 0.173986717075478 0.227627076976849 1 28.8512 28.4729 34.7332 30.8462 GeneID:79102,Genbank:NM_032015.4,HGNC:HGNC:14646,MIM:606130 ring finger protein 26 GO:0005789,GO:0007032,GO:0008270,GO:0016021,GO:0016567,GO:0032479,GO:0050687,GO:0061630,GO:0070979,GO:1905719 endoplasmic reticulum membrane|endosome organization|zinc ion binding|integral component of membrane|protein ubiquitination|regulation of type I interferon production|negative regulation of defense response to virus|ubiquitin protein ligase activity|protein K11-linked ubiquitination|protein localization to perinuclear region of cytoplasm RNF31 883.346574625839 820.105540181017 946.587609070661 1.1542265753524 0.206926453664423 0.286968265225485 1 9.56509 9.66641 13.197 9.85677 GeneID:55072,Genbank:NM_001310332.1,HGNC:HGNC:16031,MIM:612487 ring finger protein 31 GO:0000209,GO:0004842,GO:0005829,GO:0007249,GO:0009898,GO:0010803,GO:0023035,GO:0031625,GO:0035631,GO:0043123,GO:0043130,GO:0046872,GO:0050852,GO:0051092,GO:0071797,GO:0097039,GO:1903955 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|I-kappaB kinase/NF-kappaB signaling|cytoplasmic side of plasma membrane|regulation of tumor necrosis factor-mediated signaling pathway|CD40 signaling pathway|ubiquitin protein ligase binding|CD40 receptor complex|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|metal ion binding|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|LUBAC complex|protein linear polyubiquitination|positive regulation of protein targeting to mitochondrion hsa04217,hsa04621 Necroptosis|NOD-like receptor signaling pathway RNF32 19.3921255392655 16.0086601303222 22.7755909482087 1.42270438392711 0.508635923180151 0.437849454057146 1 0.0839559 0.0523993 0.0713188 0.107967 GeneID:140545,Genbank:XM_024446666.1,HGNC:HGNC:17118,MIM:610241 ring finger protein 32 GO:0005768,GO:0016235,GO:0046872 endosome|aggresome|metal ion binding RNF34 823.146431688631 865.527276083034 780.765587294228 0.902069303728477 -0.148689818497034 0.34144658194647 1 10.9543 11.9923 11.2055 10.0668 GeneID:80196,Genbank:NM_025126.3,HGNC:HGNC:17297,MIM:608299 ring finger protein 34 GO:0002039,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0012505,GO:0016567,GO:0016604,GO:0016607,GO:0031625,GO:0035872,GO:0042787,GO:0043161,GO:0046872,GO:0061630,GO:0070417,GO:0070936,GO:1901797,GO:1901981,GO:1902042,GO:2000374,GO:2001271 p53 binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|apoptotic process|endomembrane system|protein ubiquitination|nuclear body|nuclear speck|ubiquitin protein ligase binding|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity|cellular response to cold|protein K48-linked ubiquitination|negative regulation of signal transduction by p53 class mediator|phosphatidylinositol phosphate binding|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of oxygen metabolic process|negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis RNF38 775.640904120758 895.909669002681 655.372139238835 0.731515868076733 -0.451038935175256 0.17645792022619 1 6.86947 6.36302 6.30432 3.65133 GeneID:152006,Genbank:XM_017014296.1,HGNC:HGNC:18052,MIM:612488 ring finger protein 38 GO:0004842,GO:0005634,GO:0005654,GO:0008584,GO:0016567,GO:0036126,GO:0043161,GO:0046872,GO:0061630 ubiquitin-protein transferase activity|nucleus|nucleoplasm|male gonad development|protein ubiquitination|sperm flagellum|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity RNF39 23.0756135952225 29.6728244553355 16.4784027351094 0.555336508660079 -0.848565850890951 0.151988265598934 1 0.0498243 0.071882 0.0420467 0.0342983 GeneID:80352,Genbank:NM_025236.3,HGNC:HGNC:18064,MIM:607524 ring finger protein 39 GO:0005737,GO:0046872 cytoplasm|metal ion binding RNF4 3128.85329818572 3218.98871368916 3038.71788268227 0.94399768155748 -0.0831447785307892 0.541607155573829 1 33.9986 33.4355 34.5771 30.6456 GeneID:6047,Genbank:NM_002938.4,HGNC:HGNC:10067,MIM:602850 ring finger protein 4 GO:0003677,GO:0003700,GO:0003713,GO:0004842,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0008270,GO:0016567,GO:0016605,GO:0030521,GO:0031491,GO:0032184,GO:0042802,GO:0043161,GO:0045893,GO:0045944,GO:0046685,GO:0050681,GO:0051865,GO:0061630,GO:0070534,GO:0070936,GO:0070979,GO:0085020,GO:0090169,GO:0090234 DNA binding|DNA binding transcription factor activity|transcription coactivator activity|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|zinc ion binding|protein ubiquitination|PML body|androgen receptor signaling pathway|nucleosome binding|SUMO polymer binding|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|response to arsenic-containing substance|androgen receptor binding|protein autoubiquitination|ubiquitin protein ligase activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination|regulation of spindle assembly|regulation of kinetochore assembly RNF40 3005.56897663009 2961.83382518223 3049.30412807795 1.02953248158355 0.0419893474837851 0.779230572144637 1 16.5332 17.6829 18.2856 17.312 GeneID:9810,Genbank:NM_014771.3,HGNC:HGNC:16867,MIM:607700 ring finger protein 40 GO:0000151,GO:0003730,GO:0004842,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0010390,GO:0016020,GO:0016567,GO:0017075,GO:0019898,GO:0031624,GO:0031625,GO:0032403,GO:0033503,GO:0033523,GO:0042803,GO:0043005,GO:0043434,GO:0043679,GO:0046872,GO:1900364,GO:1901800,GO:1902916,GO:2001168 ubiquitin ligase complex|mRNA 3'-UTR binding|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|histone monoubiquitination|membrane|protein ubiquitination|syntaxin-1 binding|extrinsic component of membrane|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|protein complex binding|HULC complex|histone H2B ubiquitination|protein homodimerization activity|neuron projection|response to peptide hormone|axon terminus|metal ion binding|negative regulation of mRNA polyadenylation|positive regulation of proteasomal protein catabolic process|positive regulation of protein polyubiquitination|positive regulation of histone H2B ubiquitination RNF41 1459.04461695962 1437.13246585551 1480.95676806373 1.03049426775153 0.0433364797345794 0.776352033468262 1 8.74587 9.42721 9.19017 9.84915 GeneID:10193,Genbank:NM_194359.2,HGNC:HGNC:18401 ring finger protein 41 GO:0000209,GO:0004842,GO:0005128,GO:0005135,GO:0006914,GO:0008270,GO:0008285,GO:0010498,GO:0017160,GO:0019904,GO:0030336,GO:0030971,GO:0043408,GO:0045619,GO:0045637,GO:0045732,GO:0048471,GO:0051091,GO:0051865,GO:0051896,GO:0061630,GO:0071782,GO:0097191,GO:1901525,GO:2000114,GO:2000379 protein polyubiquitination|ubiquitin-protein transferase activity|erythropoietin receptor binding|interleukin-3 receptor binding|autophagy|zinc ion binding|negative regulation of cell proliferation|proteasomal protein catabolic process|Ral GTPase binding|protein domain specific binding|negative regulation of cell migration|receptor tyrosine kinase binding|regulation of MAPK cascade|regulation of lymphocyte differentiation|regulation of myeloid cell differentiation|positive regulation of protein catabolic process|perinuclear region of cytoplasm|positive regulation of DNA binding transcription factor activity|protein autoubiquitination|regulation of protein kinase B signaling|ubiquitin protein ligase activity|endoplasmic reticulum tubular network|extrinsic apoptotic signaling pathway|negative regulation of mitophagy|regulation of establishment of cell polarity|positive regulation of reactive oxygen species metabolic process hsa04144 Endocytosis RNF43 28.0567905863788 27.0303623468089 29.0832188259487 1.07594631743374 0.105606098801458 0.890247619667659 1 0.101961 0.109446 0.161042 0.10034 GeneID:54894,Genbank:NM_001305544.1,HGNC:HGNC:18505,MIM:612482 ring finger protein 43 GO:0004842,GO:0005109,GO:0005635,GO:0005789,GO:0005886,GO:0005887,GO:0016055,GO:0016567,GO:0030178,GO:0038018,GO:0042787,GO:0046872,GO:0061630,GO:0072089 ubiquitin-protein transferase activity|frizzled binding|nuclear envelope|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|Wnt signaling pathway|protein ubiquitination|negative regulation of Wnt signaling pathway|Wnt receptor catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity|stem cell proliferation RNF44 716.002227285055 772.944032734379 659.060421835731 0.852662539491027 -0.229953219617601 0.151351544819856 1 5.95827 5.855 4.73109 5.25722 GeneID:22838,Genbank:NM_014901.4,HGNC:HGNC:19180 ring finger protein 44 GO:0043161,GO:0046872,GO:0061630 proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity RNF5 2731.66983436079 2807.38591532736 2655.95375339421 0.946059371066024 -0.0799973704613818 0.672444618206969 1 119.215 122.89 104.336 127.172 GeneID:6048,Genbank:NM_006913.3,HGNC:HGNC:10068,MIM:602677 ring finger protein 5 GO:0004842,GO:0005783,GO:0005789,GO:0008270,GO:0009617,GO:0010507,GO:0016021,GO:0031648,GO:0031966,GO:0036503,GO:0042787,GO:0042802,GO:0044257,GO:0044322,GO:0044390,GO:0055085,GO:0070534,GO:0070936,GO:0071712,GO:1904264,GO:1904380,GO:2000785 ubiquitin-protein transferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|zinc ion binding|response to bacterium|negative regulation of autophagy|integral component of membrane|protein destabilization|mitochondrial membrane|ERAD pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|identical protein binding|cellular protein catabolic process|endoplasmic reticulum quality control compartment|ubiquitin-like protein conjugating enzyme binding|transmembrane transport|protein K63-linked ubiquitination|protein K48-linked ubiquitination|ER-associated misfolded protein catabolic process|ubiquitin protein ligase activity involved in ERAD pathway|endoplasmic reticulum mannose trimming|regulation of autophagosome assembly hsa04141 Protein processing in endoplasmic reticulum RNF6 288.402770326733 294.238652923136 282.56688773033 0.960332318419581 -0.0583943649146028 0.808685686647151 1 2.35588 2.05015 2.44815 1.8372 GeneID:6049,Genbank:NM_183045.1,HGNC:HGNC:10069,MIM:604242 ring finger protein 6 GO:0003677,GO:0004842,GO:0005634,GO:0005737,GO:0006355,GO:0006511,GO:0016605,GO:0030424,GO:0030517,GO:0031965,GO:0043161,GO:0043231,GO:0044314,GO:0045893,GO:0046872,GO:0050681,GO:0060765,GO:0061630,GO:0070936,GO:0085020 DNA binding|ubiquitin-protein transferase activity|nucleus|cytoplasm|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|PML body|axon|negative regulation of axon extension|nuclear membrane|proteasome-mediated ubiquitin-dependent protein catabolic process|intracellular membrane-bounded organelle|protein K27-linked ubiquitination|positive regulation of transcription, DNA-templated|metal ion binding|androgen receptor binding|regulation of androgen receptor signaling pathway|ubiquitin protein ligase activity|protein K48-linked ubiquitination|protein K6-linked ubiquitination RNF7 1211.03884377893 1228.0299327023 1194.04775485556 0.972327891249389 -0.0404851891742913 0.772178170547643 1 27.4901 31.0968 27.3661 29.9041 GeneID:9616,Genbank:NM_014245.4,HGNC:HGNC:10070,MIM:603863 ring finger protein 7 hsa04120,hsa05170 Ubiquitin mediated proteolysis|Human immunodeficiency virus 1 infection RNF8 688.425716219794 712.906398667903 663.945033771686 0.931321468024829 -0.102648860214419 0.525625182155542 1 3.81846 3.96804 3.67013 3.61881 GeneID:9025,Genbank:NM_003958.3,HGNC:HGNC:10071,MIM:611685 ring finger protein 8 GO:0000151,GO:0000781,GO:0003682,GO:0004842,GO:0005634,GO:0005654,GO:0005829,GO:0006302,GO:0006303,GO:0006511,GO:0006974,GO:0007049,GO:0007286,GO:0008270,GO:0010212,GO:0030496,GO:0031625,GO:0033522,GO:0033523,GO:0034244,GO:0035093,GO:0035861,GO:0036297,GO:0042393,GO:0042802,GO:0042803,GO:0043486,GO:0045190,GO:0045739,GO:0051301,GO:0051865,GO:0070534,GO:0070535,GO:0070936 ubiquitin ligase complex|chromosome, telomeric region|chromatin binding|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytosol|double-strand break repair|double-strand break repair via nonhomologous end joining|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|cell cycle|spermatid development|zinc ion binding|response to ionizing radiation|midbody|ubiquitin protein ligase binding|histone H2A ubiquitination|histone H2B ubiquitination|negative regulation of transcription elongation from RNA polymerase II promoter|spermatogenesis, exchange of chromosomal proteins|site of double-strand break|interstrand cross-link repair|histone binding|identical protein binding|protein homodimerization activity|histone exchange|isotype switching|positive regulation of DNA repair|cell division|protein autoubiquitination|protein K63-linked ubiquitination|histone H2A K63-linked ubiquitination|protein K48-linked ubiquitination RNFT1 356.043328648142 369.900736922455 342.185920373829 0.925074989633134 -0.112357774894394 0.566751778853855 1 7.98327 8.14439 8.80904 6.83214 GeneID:51136,Genbank:NM_016125.3,HGNC:HGNC:30206,MIM:615172 ring finger protein, transmembrane 1 GO:0005789,GO:0016021,GO:0016567,GO:0016740,GO:0046872 endoplasmic reticulum membrane|integral component of membrane|protein ubiquitination|transferase activity|metal ion binding RNFT2 107.465947025381 121.871857606511 93.0600364442513 0.763589217985955 -0.389131363109386 0.176329073408357 1 1.21526 1.45207 1.17174 0.972443 GeneID:84900,Genbank:NM_001109903.1,HGNC:HGNC:25905 ring finger protein, transmembrane 2 GO:0016021,GO:0046872 integral component of membrane|metal ion binding RNGTT 682.21795939649 739.224141547836 625.211777245144 0.845767531260592 -0.241666918049201 0.153846868826516 1 4.60446 3.9749 4.02898 3.31228 GeneID:8732,Genbank:NM_001286428.1,HGNC:HGNC:10073,MIM:603512 RNA guanylyltransferase and 5'-phosphatase GO:0004484,GO:0004651,GO:0004725,GO:0005525,GO:0005634,GO:0005654,GO:0006366,GO:0006370,GO:0006396,GO:0008138,GO:0008192,GO:0016032,GO:0050355 mRNA guanylyltransferase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|GTP binding|nucleus|nucleoplasm|transcription from RNA polymerase II promoter|7-methylguanosine mRNA capping|RNA processing|protein tyrosine/serine/threonine phosphatase activity|RNA guanylyltransferase activity|viral process|triphosphatase activity hsa03015 mRNA surveillance pathway RNH1 2389.75694635248 2305.10232429493 2474.41156841002 1.07344977371748 0.102254689656017 0.481607180472109 1 29.9794 31.737 33.8875 34.5495 GeneID:6050,Genbank:NM_203388.2,HGNC:HGNC:10074,MIM:173320 ribonuclease/angiogenin inhibitor 1 GO:0005654,GO:0005829,GO:0006402,GO:0008428,GO:0032311,GO:0045765,GO:0070062 nucleoplasm|cytosol|mRNA catabolic process|ribonuclease inhibitor activity|angiogenin-PRI complex|regulation of angiogenesis|extracellular exosome RNLS 61.6321215674939 63.6504303238094 59.6138128111783 0.936581457625728 -0.0945236189432883 0.819493339843898 1 0.0476251 0.0343361 0.0448108 0.0461448 GeneID:55328,Genbank:XM_017016382.2,HGNC:HGNC:25641,MIM:609360 renalase, FAD dependent amine oxidase GO:0002931,GO:0005576,GO:0005615,GO:0010459,GO:0016651,GO:0034356,GO:0045776,GO:0051379,GO:0055114,GO:0070404,GO:0071871,GO:0097621,GO:1902074 response to ischemia|extracellular region|extracellular space|negative regulation of heart rate|oxidoreductase activity, acting on NAD(P)H|NAD biosynthesis via nicotinamide riboside salvage pathway|negative regulation of blood pressure|epinephrine binding|oxidation-reduction process|NADH binding|response to epinephrine|monoamine oxidase activity|response to salt RNMT 345.327266969841 367.344518708191 323.310015231492 0.880127506375893 -0.184215548988933 0.54788143736663 1 2.16701 2.02493 2.36877 1.42545 GeneID:8731,Genbank:XM_024451280.1,HGNC:HGNC:10075,MIM:603514 RNA guanine-7 methyltransferase GO:0001650,GO:0003723,GO:0004482,GO:0005634,GO:0005654,GO:0005845,GO:0006366,GO:0006370,GO:0031533,GO:0043235,GO:1990830 fibrillar center|RNA binding|mRNA (guanine-N7-)-methyltransferase activity|nucleus|nucleoplasm|mRNA cap binding complex|transcription from RNA polymerase II promoter|7-methylguanosine mRNA capping|mRNA cap methyltransferase complex|receptor complex|cellular response to leukemia inhibitory factor hsa03015 mRNA surveillance pathway RNPC3 63.7287405963927 62.0263286387746 65.4311525540107 1.05489320406283 0.0770969498634524 0.828450251015407 1 1.19254 0.793656 0.883485 0.803744 GeneID:55599,Genbank:NM_017619.3,HGNC:HGNC:18666 RNA binding region (RNP1, RRM) containing 3 GO:0000398,GO:0005634,GO:0005654,GO:0005689,GO:0008380,GO:0030626,GO:0032502,GO:0097157 mRNA splicing, via spliceosome|nucleus|nucleoplasm|U12-type spliceosomal complex|RNA splicing|U12 snRNA binding|developmental process|pre-mRNA intronic binding RNPEP 3019.83465089453 2855.33647748003 3184.33282430903 1.11522156825432 0.157330368141649 0.259277628617287 1 36.6788 40.3098 41.9432 44.9458 GeneID:6051,Genbank:NM_020216.3,HGNC:HGNC:10078,MIM:602675 arginyl aminopeptidase GO:0004177,GO:0004301,GO:0005576,GO:0005886,GO:0006508,GO:0008235,GO:0008270,GO:0030141,GO:0042277,GO:0043171,GO:0045776,GO:0070006,GO:0070062 aminopeptidase activity|epoxide hydrolase activity|extracellular region|plasma membrane|proteolysis|metalloexopeptidase activity|zinc ion binding|secretory granule|peptide binding|peptide catabolic process|negative regulation of blood pressure|metalloaminopeptidase activity|extracellular exosome RNPEPL1 1343.47126625674 1209.33078418876 1477.61174832471 1.22184249970608 0.289058328088363 0.0514100182003126 0.828352969312079 18.8671 19.1493 23.8444 23.486 GeneID:57140,Genbank:XM_005247036.4,HGNC:HGNC:10079,MIM:605287 arginyl aminopeptidase like 1 GO:0005737,GO:0006508,GO:0008270,GO:0042277,GO:0043171,GO:0070006 cytoplasm|proteolysis|zinc ion binding|peptide binding|peptide catabolic process|metalloaminopeptidase activity RNPS1 2631.1581192693 2601.27081985972 2661.04541867888 1.02297899871201 0.0327765275221135 0.819180574853204 1 31.0916 31.6627 33.1646 31.9439 GeneID:10921,Genbank:NM_001286627.1,HGNC:HGNC:10080,MIM:606447 RNA binding protein with serine rich domain 1 GO:0000184,GO:0000381,GO:0000398,GO:0003723,GO:0003730,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006369,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124,GO:0043065,GO:0048025,GO:0061574 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA 3'-UTR binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing|positive regulation of apoptotic process|negative regulation of mRNA splicing, via spliceosome|ASAP complex hsa03013,hsa03015 RNA transport|mRNA surveillance pathway ROBO1 1165.73642744312 1199.19891287851 1132.27394200773 0.944191935005894 -0.0828479349455556 0.807684289071412 1 4.76308 3.76848 4.87454 3.23175 GeneID:6091,Genbank:NM_002941.3,HGNC:HGNC:10249,MIM:602430 roundabout guidance receptor 1 hsa04360 Axon guidance ROBO2 66.3236306055787 64.2943892049296 68.3528720062279 1.0631234366091 0.0883091143150423 0.890960968361727 1 0.155798 0.19356 0.271187 0.135721 GeneID:6092,Genbank:XM_017006997.1,HGNC:HGNC:10250,MIM:602431 roundabout guidance receptor 2 GO:0001656,GO:0001657,GO:0005886,GO:0007156,GO:0007411,GO:0007417,GO:0007420,GO:0008046,GO:0009986,GO:0016021,GO:0016199,GO:0021510,GO:0021891,GO:0030673,GO:0031290,GO:0032870,GO:0035385,GO:0042802,GO:0050772,GO:0050925,GO:0051964,GO:0061364,GO:0070062 metanephros development|ureteric bud development|plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|axon guidance|central nervous system development|brain development|axon guidance receptor activity|cell surface|integral component of membrane|axon midline choice point recognition|spinal cord development|olfactory bulb interneuron development|axolemma|retinal ganglion cell axon guidance|cellular response to hormone stimulus|Roundabout signaling pathway|identical protein binding|positive regulation of axonogenesis|negative regulation of negative chemotaxis|negative regulation of synapse assembly|apoptotic process involved in luteolysis|extracellular exosome hsa04360 Axon guidance ROBO3 141.162452627782 158.751674267152 123.573230988413 0.778405843962693 -0.36140555354487 0.155758287479385 1 0.744791 0.997886 0.72966 0.651412 GeneID:64221,Genbank:NM_022370.3,HGNC:HGNC:13433,MIM:608630 roundabout guidance receptor 3 GO:0005886,GO:0007411,GO:0016021,GO:0016199,GO:0030424,GO:0035385 plasma membrane|axon guidance|integral component of membrane|axon midline choice point recognition|axon|Roundabout signaling pathway hsa04360 Axon guidance ROBO4 7.7075570420126 9.59951428529953 5.81559979872566 0.605822297450146 -0.723033417003732 0.508231618498743 1 0.0721699 0.125088 0.0665937 0.0521226 GeneID:54538,Genbank:NM_001301088.1,HGNC:HGNC:17985,MIM:607528 roundabout guidance receptor 4 GO:0001525,GO:0004872,GO:0016021,GO:0030154,GO:0030334,GO:0070062 angiogenesis|receptor activity|integral component of membrane|cell differentiation|regulation of cell migration|extracellular exosome ROCK1 171.847025332025 168.21590138265 175.4781492814 1.04317218431229 0.0609773064207726 0.878389999816641 1 0.875823 0.693059 0.976658 0.556298 GeneID:6093,Genbank:NM_005406.2,HGNC:HGNC:10251,MIM:601702 Rho associated coiled-coil containing protein kinase 1 GO:0000139,GO:0001726,GO:0003383,GO:0004672,GO:0004674,GO:0005524,GO:0005576,GO:0005814,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0006939,GO:0007159,GO:0007165,GO:0007186,GO:0007249,GO:0007266,GO:0010506,GO:0010508,GO:0010628,GO:0016525,GO:0017049,GO:0022614,GO:0030027,GO:0030036,GO:0030155,GO:0030866,GO:0031175,GO:0032059,GO:0032060,GO:0032091,GO:0032956,GO:0034774,GO:0035509,GO:0043312,GO:0043524,GO:0045616,GO:0045664,GO:0046872,GO:0048010,GO:0048013,GO:0050900,GO:0050901,GO:0051045,GO:0051451,GO:0051492,GO:0051893,GO:0051894,GO:0072659,GO:0097194,GO:0140058,GO:1900223,GO:1900242,GO:1902003,GO:1902430,GO:1902992,GO:1903140,GO:1903347,GO:2000114,GO:2000145 Golgi membrane|ruffle|apical constriction|protein kinase activity|protein serine/threonine kinase activity|ATP binding|extracellular region|centriole|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|smooth muscle contraction|leukocyte cell-cell adhesion|signal transduction|G-protein coupled receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|Rho protein signal transduction|regulation of autophagy|positive regulation of autophagy|positive regulation of gene expression|negative regulation of angiogenesis|GTP-Rho binding|membrane to membrane docking|lamellipodium|actin cytoskeleton organization|regulation of cell adhesion|cortical actin cytoskeleton organization|neuron projection development|bleb|bleb assembly|negative regulation of protein binding|regulation of actin cytoskeleton organization|secretory granule lumen|negative regulation of myosin-light-chain-phosphatase activity|neutrophil degranulation|negative regulation of neuron apoptotic process|regulation of keratinocyte differentiation|regulation of neuron differentiation|metal ion binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|leukocyte migration|leukocyte tethering or rolling|negative regulation of membrane protein ectodomain proteolysis|myoblast migration|regulation of stress fiber assembly|regulation of focal adhesion assembly|positive regulation of focal adhesion assembly|protein localization to plasma membrane|execution phase of apoptosis|neuron projection arborization|positive regulation of amyloid-beta clearance|regulation of synaptic vesicle endocytosis|regulation of amyloid-beta formation|negative regulation of amyloid-beta formation|negative regulation of amyloid precursor protein catabolic process|regulation of establishment of endothelial barrier|negative regulation of bicellular tight junction assembly|regulation of establishment of cell polarity|regulation of cell motility hsa04022,hsa04024,hsa04062,hsa04071,hsa04270,hsa04350,hsa04360,hsa04510,hsa04530,hsa04611,hsa04670,hsa04810,hsa04921,hsa05130,hsa05131,hsa05132,hsa05163,hsa05200,hsa05205,hsa05206 cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Vascular smooth muscle contraction|TGF-beta signaling pathway|Axon guidance|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer ROCK2 238.861289884778 227.551741638213 250.170838131344 1.09940199240089 0.136718999027406 0.841200288188326 1 0.8101 0.63724 1.29595 0.445766 GeneID:9475,Genbank:NM_001321643.1,HGNC:HGNC:10252,MIM:604002 Rho associated coiled-coil containing protein kinase 2 hsa04022,hsa04024,hsa04062,hsa04071,hsa04270,hsa04310,hsa04360,hsa04510,hsa04530,hsa04611,hsa04670,hsa04810,hsa04921,hsa05130,hsa05131,hsa05132,hsa05163,hsa05200,hsa05205 cGMP-PKG signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Sphingolipid signaling pathway|Vascular smooth muscle contraction|Wnt signaling pathway|Axon guidance|Focal adhesion|Tight junction|Platelet activation|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Oxytocin signaling pathway|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Human cytomegalovirus infection|Pathways in cancer|Proteoglycans in cancer ROGDI 267.534033075705 269.495968452698 265.572097698711 0.985439964922236 -0.021160112961288 0.921540763487509 1 5.71476 5.18321 5.41393 5.1822 GeneID:79641,Genbank:NM_024589.2,HGNC:HGNC:29478,MIM:614574 rogdi homolog GO:0005622,GO:0005635,GO:0007420,GO:0008284,GO:0022008,GO:0030097,GO:0042475 intracellular|nuclear envelope|brain development|positive regulation of cell proliferation|neurogenesis|hemopoiesis|odontogenesis of dentin-containing tooth ROM1 123.713270893461 102.058296120116 145.368245666807 1.42436481102642 0.510318699431435 0.205880140664664 1 1.96969 2.73565 3.25555 4.25597 GeneID:6094,Genbank:NM_000327.3,HGNC:HGNC:10254,MIM:180721 retinal outer segment membrane protein 1 ROMO1 1294.79081318812 1304.55852364766 1285.02310272859 0.985025262903162 -0.0217673691023751 0.929099087556187 1 193.718 229.46 181.066 251.696 GeneID:140823,Genbank:XM_017027678.1,HGNC:HGNC:16185 reactive oxygen species modulator 1 GO:0001302,GO:0005739,GO:0005743,GO:0008284,GO:0016021,GO:0031640,GO:0034614,GO:0042742,GO:0050829,GO:0050830,GO:0051715,GO:0061844,GO:2000379 replicative cell aging|mitochondrion|mitochondrial inner membrane|positive regulation of cell proliferation|integral component of membrane|killing of cells of other organism|cellular response to reactive oxygen species|defense response to bacterium|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|cytolysis in other organism|antimicrobial humoral immune response mediated by antimicrobial peptide|positive regulation of reactive oxygen species metabolic process ROPN1 3.18565834481936 2.00831188251439 4.36300480712434 2.17247373035601 1.11933873201586 0.59575182352266 1 0.0403643 0.109385 0.189831 0.105895 GeneID:54763,Genbank:XM_011512933.2,HGNC:HGNC:17692,MIM:611757 rhophilin associated tail protein 1 GO:0001932,GO:0005634,GO:0005737,GO:0030317,GO:0042802,GO:0042995,GO:0044782,GO:0048240,GO:0061512 regulation of protein phosphorylation|nucleus|cytoplasm|flagellated sperm motility|identical protein binding|cell projection|cilium organization|sperm capacitation|protein localization to cilium ROPN1L 1.51824048055703 3.03648096111406 0 0 -Inf 0.221951500672507 1 0.0265353 0.0724945 0 0 GeneID:83853,Genbank:NM_031916.4,HGNC:HGNC:24060,MIM:611756 rhophilin associated tail protein 1 like GO:0001932,GO:0003351,GO:0005737,GO:0030317,GO:0031514,GO:0048240 regulation of protein phosphorylation|epithelial cilium movement|cytoplasm|flagellated sperm motility|motile cilium|sperm capacitation ROR1 24.4664650659136 21.7934644044407 27.1394657273864 1.24530295981103 0.316496766747951 0.625069636993619 1 0.0536098 0.0863868 0.0990254 0.0995232 GeneID:4919,Genbank:NM_005012.3,HGNC:HGNC:10256,MIM:602336 receptor tyrosine kinase like orphan receptor 1 GO:0001725,GO:0004714,GO:0005524,GO:0005737,GO:0005886,GO:0005887,GO:0007169,GO:0007605,GO:0009986,GO:0014002,GO:0017147,GO:0030424,GO:0042813,GO:0043123,GO:0043235,GO:0043679,GO:0048839,GO:0051092,GO:1904929 stress fiber|transmembrane receptor protein tyrosine kinase activity|ATP binding|cytoplasm|plasma membrane|integral component of plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|sensory perception of sound|cell surface|astrocyte development|Wnt-protein binding|axon|Wnt-activated receptor activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|axon terminus|inner ear development|positive regulation of NF-kappaB transcription factor activity|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway ROR2 54.0612581817411 52.8786681358554 55.2438482276268 1.04472843540035 0.0631279798021702 0.893357560659919 1 0.291199 0.257962 0.254199 0.292314 GeneID:4920,Genbank:NM_004560.3,HGNC:HGNC:10257,MIM:602337 receptor tyrosine kinase like orphan receptor 2 RORA 11.654510557244 13.126066648371 10.182954466117 0.775781103273673 -0.366278460221169 0.738113285898694 1 0.00927834 0.0194967 0.0214126 0.00664895 GeneID:6095,Genbank:NM_134261.2,HGNC:HGNC:10258,MIM:600825 RAR related orphan receptor A GO:0000977,GO:0001046,GO:0001222,GO:0001223,GO:0001228,GO:0001525,GO:0003677,GO:0003700,GO:0003707,GO:0004879,GO:0005634,GO:0005654,GO:0006355,GO:0006367,GO:0006805,GO:0006809,GO:0008013,GO:0008134,GO:0008142,GO:0008270,GO:0008589,GO:0010575,GO:0010906,GO:0019218,GO:0019221,GO:0021702,GO:0021930,GO:0030522,GO:0032922,GO:0036315,GO:0042692,GO:0042753,GO:0043030,GO:0043124,GO:0043565,GO:0045599,GO:0045893,GO:0045944,GO:0046068,GO:0050728,GO:0060850,GO:0070328,GO:0071347,GO:0071356,GO:0071456,GO:0072539,GO:0098531,GO:2000188 RNA polymerase II regulatory region sequence-specific DNA binding|core promoter sequence-specific DNA binding|transcription corepressor binding|transcription coactivator binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|angiogenesis|DNA binding|DNA binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|xenobiotic metabolic process|nitric oxide biosynthetic process|beta-catenin binding|transcription factor binding|oxysterol binding|zinc ion binding|regulation of smoothened signaling pathway|positive regulation of vascular endothelial growth factor production|regulation of glucose metabolic process|regulation of steroid metabolic process|cytokine-mediated signaling pathway|cerebellar Purkinje cell differentiation|cerebellar granule cell precursor proliferation|intracellular receptor signaling pathway|circadian regulation of gene expression|cellular response to sterol|muscle cell differentiation|positive regulation of circadian rhythm|regulation of macrophage activation|negative regulation of I-kappaB kinase/NF-kappaB signaling|sequence-specific DNA binding|negative regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|cGMP metabolic process|negative regulation of inflammatory response|regulation of transcription involved in cell fate commitment|triglyceride homeostasis|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to hypoxia|T-helper 17 cell differentiation|transcription factor activity, direct ligand regulated sequence-specific DNA binding|regulation of cholesterol homeostasis hsa04659,hsa04710,hsa05321 Th17 cell differentiation|Circadian rhythm|Inflammatory bowel disease (IBD) RORB 26.7061941749976 19.4871862187087 33.9252021312864 1.7408979290564 0.799831618519741 0.148956722570601 1 0.207193 0.219394 0.375181 0.338412 GeneID:6096,Genbank:NM_006914.3,HGNC:HGNC:10259,MIM:601972 RAR related orphan receptor B GO:0000978,GO:0001077,GO:0003700,GO:0003707,GO:0004879,GO:0005634,GO:0005654,GO:0006355,GO:0006367,GO:0007601,GO:0008134,GO:0008270,GO:0035881,GO:0042462,GO:0042752,GO:0045668,GO:0045892,GO:0045893,GO:0046548,GO:0046549,GO:0048511,GO:0060041,GO:0071300 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|visual perception|transcription factor binding|zinc ion binding|amacrine cell differentiation|eye photoreceptor cell development|regulation of circadian rhythm|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|retinal rod cell development|retinal cone cell development|rhythmic process|retina development in camera-type eye|cellular response to retinoic acid hsa04710 Circadian rhythm RORC 1.24919164223588 2.49838328447175 0 0 -Inf 0.305439822927553 1 0.0104611 0.0186997 0 0 GeneID:6097,Genbank:XM_006711484.4,HGNC:HGNC:10260,MIM:602943 RAR related orphan receptor C GO:0000122,GO:0000978,GO:0001078,GO:0003677,GO:0003700,GO:0003707,GO:0004879,GO:0005634,GO:0005654,GO:0006367,GO:0006805,GO:0008142,GO:0008270,GO:0010906,GO:0016604,GO:0019218,GO:0019221,GO:0032922,GO:0036315,GO:0042093,GO:0042753,GO:0043565,GO:0045598,GO:0045893,GO:0048535,GO:0048541,GO:0060612,GO:0060850,GO:0070244,GO:0072539,GO:0098531 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|steroid hormone receptor activity|nuclear receptor activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|xenobiotic metabolic process|oxysterol binding|zinc ion binding|regulation of glucose metabolic process|nuclear body|regulation of steroid metabolic process|cytokine-mediated signaling pathway|circadian regulation of gene expression|cellular response to sterol|T-helper cell differentiation|positive regulation of circadian rhythm|sequence-specific DNA binding|regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|lymph node development|Peyer's patch development|adipose tissue development|regulation of transcription involved in cell fate commitment|negative regulation of thymocyte apoptotic process|T-helper 17 cell differentiation|transcription factor activity, direct ligand regulated sequence-specific DNA binding hsa04659,hsa04710,hsa05321 Th17 cell differentiation|Circadian rhythm|Inflammatory bowel disease (IBD) ROS1 9.8735197011572 11.9920363652935 7.75500303702094 0.646679412969839 -0.628877411947184 0.540621338682075 1 0.0437503 0.0197333 0.0225333 0.0183519 GeneID:6098,Genbank:XM_017011173.1,HGNC:HGNC:10261,MIM:165020 ROS proto-oncogene 1, receptor tyrosine kinase GO:0001558,GO:0002066,GO:0004713,GO:0004714,GO:0005524,GO:0005886,GO:0006468,GO:0007169,GO:0007283,GO:0008283,GO:0009986,GO:0010629,GO:0010966,GO:0016020,GO:0016021,GO:0019903,GO:0023014,GO:0030154,GO:0032006,GO:0038083,GO:0048471,GO:0070372 regulation of cell growth|columnar/cuboidal epithelial cell development|protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity|ATP binding|plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|spermatogenesis|cell proliferation|cell surface|negative regulation of gene expression|regulation of phosphate transport|membrane|integral component of membrane|protein phosphatase binding|signal transduction by protein phosphorylation|cell differentiation|regulation of TOR signaling|peptidyl-tyrosine autophosphorylation|perinuclear region of cytoplasm|regulation of ERK1 and ERK2 cascade RP1 4.0032460445499 5.58289052027075 2.42360156882906 0.434112322287043 -1.20385972078746 0.466314521069473 1 0.0043994 0.0128647 0 0.00396152 GeneID:6101,Genbank:XM_017013721.1,HGNC:HGNC:10263,MIM:603937 RP1, axonemal microtubule associated RP1L1 5.85179406494201 2.00831188251439 9.69527624736962 4.82757500554705 2.27129867435773 0.0925250005007505 0.987262097281825 0.00408844 0.0108994 0.0496821 0.0251613 GeneID:94137,Genbank:NM_178857.5,HGNC:HGNC:15946,MIM:608581 RP1 like 1 GO:0001750,GO:0005874,GO:0005930,GO:0007601,GO:0032391,GO:0035082,GO:0035556,GO:0042461,GO:0045494,GO:0060041,GO:0070062 photoreceptor outer segment|microtubule|axoneme|visual perception|photoreceptor connecting cilium|axoneme assembly|intracellular signal transduction|photoreceptor cell development|photoreceptor cell maintenance|retina development in camera-type eye|extracellular exosome RP2 308.843058979019 330.244187984341 287.441929973697 0.870392092978565 -0.20026264431063 0.495531318110068 1 4.56106 4.55898 4.90989 3.02421 GeneID:6102,Genbank:NM_006915.2,HGNC:HGNC:10274,MIM:300757 RP2, ARL3 GTPase activating protein RP9 424.093049653033 428.977845495232 419.208253810834 0.977225882905166 -0.0332360194070272 0.847932896202323 1 6.27943 6.90883 7.25185 6.46647 GeneID:6100,Genbank:NM_203288.1,HGNC:HGNC:10288,MIM:607331 RP9, pre-mRNA splicing factor GO:0003723,GO:0005634,GO:0005785,GO:0005829,GO:0008380,GO:0046872,GO:0050890 RNA binding|nucleus|signal recognition particle receptor complex|cytosol|RNA splicing|metal ion binding|cognition hsa03040 Spliceosome RPA1 5287.35752776955 5330.13944966942 5244.57560586968 0.983947165996745 -0.0233472441611534 0.858385739807445 1 37.8819 38.8784 38.5955 37.9494 GeneID:6117,Genbank:NM_001355120.1,HGNC:HGNC:10289,MIM:179835 replication protein A1 hsa03030,hsa03420,hsa03430,hsa03440,hsa03460 DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway RPA2 2146.54305097593 2192.71227711243 2100.37382483943 0.957888477555022 -0.06207039533922 0.653770154439758 1 33.9531 35.3014 34.726 32.4955 GeneID:6118,Genbank:NM_001297558.1,HGNC:HGNC:10290,MIM:179836 replication protein A2 hsa03030,hsa03420,hsa03430,hsa03440,hsa03460 DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway RPA3 1038.7907470455 1043.95824166763 1033.62325242337 0.990100189038449 -0.0143535748309712 0.921903488591515 1 17.8842 19.2274 16.567 19.4843 GeneID:6119,Genbank:NM_002947.4,HGNC:HGNC:10291,MIM:179837 replication protein A3 hsa03030,hsa03420,hsa03430,hsa03440,hsa03460 DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway RPA4 0.971768182806039 0.490071401957362 1.45346496365472 2.96582285326082 1.56843242909583 0.837471602739444 1 0 0.0281964 0.0290432 0.0540971 GeneID:29935,Genbank:NM_013347.4,HGNC:HGNC:30305,MIM:300767 replication protein A4 hsa03030,hsa03420,hsa03430,hsa03440,hsa03460 DNA replication|Nucleotide excision repair|Mismatch repair|Homologous recombination|Fanconi anemia pathway RPAIN 1183.60838897892 1234.2067218273 1133.01005613054 0.918006713213382 -0.12342339104758 0.418341033093734 1 9.15035 8.67197 8.66755 8.9554 GeneID:84268,Genbank:NM_001033002.3,HGNC:HGNC:28641,MIM:617299 RPA interacting protein GO:0001650,GO:0005634,GO:0005737,GO:0006261,GO:0006281,GO:0006310,GO:0006606,GO:0009411,GO:0016605,GO:0032403,GO:0046872 fibrillar center|nucleus|cytoplasm|DNA-dependent DNA replication|DNA repair|DNA recombination|protein import into nucleus|response to UV|PML body|protein complex binding|metal ion binding RPAP1 945.154650419745 928.323042117623 961.986258721868 1.0362623947451 0.05138935791437 0.758648158883973 1 6.85399 7.30837 7.55596 7.41688 GeneID:26015,Genbank:NM_015540.3,HGNC:HGNC:24567,MIM:611475 RNA polymerase II associated protein 1 GO:0003677,GO:0003899,GO:0005634,GO:0006366 DNA binding|DNA-directed 5'-3' RNA polymerase activity|nucleus|transcription from RNA polymerase II promoter RPAP2 119.182856759251 121.074011246228 117.291702272275 0.968760356289336 -0.04578826676161 0.902433758507934 1 0.590445 0.538775 0.634254 0.481613 GeneID:79871,Genbank:NM_024813.2,HGNC:HGNC:25791,MIM:611476 RNA polymerase II associated protein 2 GO:0004722,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0008420,GO:0009301,GO:0016591,GO:0042795,GO:0046872,GO:0070940 protein serine/threonine phosphatase activity|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|CTD phosphatase activity|snRNA transcription|DNA-directed RNA polymerase II, holoenzyme|snRNA transcription from RNA polymerase II promoter|metal ion binding|dephosphorylation of RNA polymerase II C-terminal domain RPAP3 213.976034887249 235.056700146736 192.895369627762 0.820633359982273 -0.285190291738156 0.208000843718947 1 1.94864 2.00336 1.85971 1.52103 GeneID:79657,Genbank:NM_001146076.1,HGNC:HGNC:26151,MIM:611477 RNA polymerase II associated protein 3 GO:0005829,GO:0097255 cytosol|R2TP complex RPE 838.386537031668 844.635485241645 832.137588821691 0.985203207018495 -0.0215067708038902 0.924800362007434 1 6.13797 5.9646 6.18123 5.6038 GeneID:6120,Genbank:NM_001278283.1,HGNC:HGNC:10293,MIM:180480 ribulose-5-phosphate-3-epimerase GO:0004750,GO:0005829,GO:0005975,GO:0006098,GO:0009052,GO:0019323,GO:0042802,GO:0042803,GO:0044262,GO:0046872,GO:0070062 ribulose-phosphate 3-epimerase activity|cytosol|carbohydrate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|pentose catabolic process|identical protein binding|protein homodimerization activity|cellular carbohydrate metabolic process|metal ion binding|extracellular exosome hsa00030,hsa00040 Pentose phosphate pathway|Pentose and glucuronate interconversions RPE65 2.24747451206948 3.52655236307142 0.968396661067546 0.274601526184097 -1.86458845114995 0.453275686177039 1 0.0291262 0.04186 0 0.0130266 GeneID:6121,Genbank:XM_017002027.1,HGNC:HGNC:10294,MIM:180069 RPE65, retinoid isomerohydrolase hsa00830 Retinol metabolism RPEL1 5.71738522541709 4.65077399104097 6.7839964597932 1.45868117282447 0.544664584661052 0.710133950130682 1 0.11656 0.0900391 0.135191 0.167835 GeneID:729020,Genbank:NM_001143909.1,HGNC:HGNC:45241 ribulose-5-phosphate-3-epimerase like 1 GO:0004750,GO:0005829,GO:0006098,GO:0009052,GO:0019323,GO:0044262,GO:0046872 ribulose-phosphate 3-epimerase activity|cytosol|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|pentose catabolic process|cellular carbohydrate metabolic process|metal ion binding hsa00030,hsa00040 Pentose phosphate pathway|Pentose and glucuronate interconversions RPF1 975.310971354043 1070.99637866784 879.625564040243 0.821315161806957 -0.283992163837286 0.0678557743476385 0.916343630061028 21.1783 19.4945 17.7096 15.942 GeneID:80135,Genbank:NM_025065.6,HGNC:HGNC:30350 ribosome production factor 1 homolog GO:0000027,GO:0000460,GO:0000470,GO:0003723,GO:0005730,GO:0030687,GO:0042134 ribosomal large subunit assembly|maturation of 5.8S rRNA|maturation of LSU-rRNA|RNA binding|nucleolus|preribosome, large subunit precursor|rRNA primary transcript binding RPF2 799.373449163318 886.29155440802 712.455343918616 0.803861145212521 -0.314981775589952 0.0483695823964194 0.806708656465773 8.43684 8.21112 7.36776 6.02005 GeneID:84154,Genbank:NM_032194.2,HGNC:HGNC:20870 ribosome production factor 2 homolog GO:0000027,GO:0000463,GO:0003723,GO:0005634,GO:0005730,GO:0008097,GO:0019843,GO:0042273,GO:1901796,GO:1902570 ribosomal large subunit assembly|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleolus|5S rRNA binding|rRNA binding|ribosomal large subunit biogenesis|regulation of signal transduction by p53 class mediator|protein localization to nucleolus RPGR 46.8875798234326 47.2477513408997 46.5274083059655 0.984753919192114 -0.022164841298589 0.989710245198512 1 0.139834 0.134437 0.152072 0.101422 GeneID:6103,Genbank:XM_017029712.2,HGNC:HGNC:10295,MIM:312610 retinitis pigmentosa GTPase regulator RPGRIP1L 174.205003641469 166.179180535666 182.230826747271 1.09659240200766 0.133027382738009 0.587028724137118 1 0.371919 0.39866 0.421914 0.335306 GeneID:23322,Genbank:NM_001127897.3,HGNC:HGNC:29168,MIM:610937 RPGRIP1 like RPH3AL 121.096685825386 134.603905402294 107.589466248478 0.799304194978017 -0.32318343395435 0.237654433414294 1 0.496306 0.509646 0.393766 0.373527 GeneID:9501,Genbank:XM_024451031.1,HGNC:HGNC:10296,MIM:604881 rabphilin 3A like (without C2 domains) GO:0005509,GO:0005544,GO:0005737,GO:0005886,GO:0006886,GO:0006887,GO:0008092,GO:0017137,GO:0017158,GO:0030274,GO:0030658,GO:0030667,GO:0042493,GO:0042593,GO:0045744,GO:0050714 calcium ion binding|calcium-dependent phospholipid binding|cytoplasm|plasma membrane|intracellular protein transport|exocytosis|cytoskeletal protein binding|Rab GTPase binding|regulation of calcium ion-dependent exocytosis|LIM domain binding|transport vesicle membrane|secretory granule membrane|response to drug|glucose homeostasis|negative regulation of G-protein coupled receptor protein signaling pathway|positive regulation of protein secretion RPIA 302.102271580821 326.035459120572 278.16908404107 0.853186597529563 -0.229066791925127 0.2552718076896 1 7.53082 7.71469 6.52182 6.5584 GeneID:22934,Genbank:NM_144563.2,HGNC:HGNC:10297,MIM:180430 ribose 5-phosphate isomerase A GO:0004751,GO:0005829,GO:0006014,GO:0006098,GO:0009052,GO:0042802,GO:0043231,GO:0048029 ribose-5-phosphate isomerase activity|cytosol|D-ribose metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|identical protein binding|intracellular membrane-bounded organelle|monosaccharide binding hsa00030 Pentose phosphate pathway RPL10 21716.0857018314 23013.7794890488 20418.3919146141 0.887224626634239 -0.172628684042833 0.307691054809796 1 390.08 418.121 343.001 398.807 GeneID:6134,Genbank:NM_001303625.1,HGNC:HGNC:10298,MIM:312173 ribosomal protein L10 GO:0003735,GO:0006412,GO:0006417,GO:0022625,GO:0045182,GO:1990403 structural constituent of ribosome|translation|regulation of translation|cytosolic large ribosomal subunit|translation regulator activity|embryonic brain development hsa03010 Ribosome RPL10A 9330.93835844995 9983.07534577809 8678.80137112181 0.869351484439325 -0.201988508946768 0.246226740990267 1 281.906 285.754 232.333 273.866 GeneID:4736,Genbank:NM_007104.4,HGNC:HGNC:10299,MIM:615660 ribosomal protein L10a GO:0000470,GO:0003723,GO:0003735,GO:0005634,GO:0005739,GO:0005925,GO:0006412,GO:0016020,GO:0022625,GO:0045471,GO:0070062 maturation of LSU-rRNA|RNA binding|structural constituent of ribosome|nucleus|mitochondrion|focal adhesion|translation|membrane|cytosolic large ribosomal subunit|response to ethanol|extracellular exosome hsa03010 Ribosome RPL11 11296.0097367471 11291.543253632 11300.4762198622 1.00079112004706 0.00114089373617101 0.991142276185775 1 426.709 426.486 396.151 467.408 GeneID:6135,Genbank:NM_000975.4,HGNC:HGNC:10301,MIM:604175 ribosomal protein L11 GO:0003735,GO:0005654,GO:0005730,GO:0005737,GO:0005840,GO:0006412,GO:0019843,GO:0032435,GO:0034504,GO:1901798 structural constituent of ribosome|nucleoplasm|nucleolus|cytoplasm|ribosome|translation|rRNA binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein localization to nucleus|positive regulation of signal transduction by p53 class mediator hsa03010 Ribosome RPL12 15407.7139787058 16524.3864887345 14291.0414686771 0.864845510507758 -0.209485651305692 0.277854710030658 1 800.076 865.709 659.897 794.982 GeneID:6136,Genbank:NM_000976.3,HGNC:HGNC:10302,MIM:180475 ribosomal protein L12 GO:0000027,GO:0000184,GO:0003723,GO:0003735,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0019843,GO:0022625,GO:0031012,GO:0070062 ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|rRNA binding|cytosolic large ribosomal subunit|extracellular matrix|extracellular exosome hsa03010 Ribosome RPL13 18522.4081960353 19363.0500742455 17681.7663178251 0.91317051032902 -0.131043824559345 0.50431662578778 1 166.659 185.943 149.365 179.029 GeneID:6137,Genbank:NM_000977.3,HGNC:HGNC:10303,MIM:113703 ribosomal protein L13 GO:0000184,GO:0003723,GO:0003735,GO:0005634,GO:0005730,GO:0005783,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0022626 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleus|nucleolus|endoplasmic reticulum|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|cytosolic ribosome hsa03010 Ribosome RPL13A 34248.7786350619 36289.9468461196 32207.6104240043 0.88750778722753 -0.172168316740143 0.361502678332703 1 1063.36 1183.22 914.743 1089.5 GeneID:23521,Genbank:NM_012423.3,HGNC:HGNC:10304 ribosomal protein L13a GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0015934,GO:0016020,GO:0017148,GO:0019083,GO:0022625,GO:0030529,GO:0071346,GO:0097452,GO:1901194 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|nucleus|nucleolus|cytoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|large ribosomal subunit|membrane|negative regulation of translation|viral transcription|cytosolic large ribosomal subunit|intracellular ribonucleoprotein complex|cellular response to interferon-gamma|GAIT complex|negative regulation of formation of translation preinitiation complex hsa03010 Ribosome RPL14 13247.5372350884 14478.0874955926 12016.9869745843 0.830012042560347 -0.268795826360264 0.0374230950469394 0.744556882325193 612.2 636.759 507.94 555.674 GeneID:9045,Genbank:NM_003973.4,HGNC:HGNC:10305,MIM:617414 ribosomal protein L14 GO:0000184,GO:0003723,GO:0003735,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0042273,GO:0045296,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|ribosomal large subunit biogenesis|cadherin binding|extracellular exosome hsa03010 Ribosome RPL15 30741.9660062133 32632.4000286067 28851.5319838198 0.884137604299028 -0.177657171435332 0.253409739409961 1 200.906 223.917 180.203 204.558 GeneID:6138,Genbank:NM_001253384.2,HGNC:HGNC:10306,MIM:604174 ribosomal protein L15 GO:0002181,GO:0003723,GO:0003735,GO:0005634,GO:0016020,GO:0022625,GO:0031672,GO:0045296,GO:0045471,GO:0070062 cytoplasmic translation|RNA binding|structural constituent of ribosome|nucleus|membrane|cytosolic large ribosomal subunit|A band|cadherin binding|response to ethanol|extracellular exosome hsa03010 Ribosome RPL17 113.990846249227 117.989504010429 109.992188488026 0.932220110682925 -0.101257458571791 0.776023211192746 1 134.732 138.14 102.208 130.389 GeneID:6139,Genbank:NM_001199345.1,HGNC:HGNC:10307,MIM:603661 ribosomal protein L17 GO:0000184,GO:0003723,GO:0003735,GO:0005634,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleus|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit hsa03010 Ribosome RPL18 11187.4810849414 12090.9616734341 10284.0004964487 0.850552733042267 -0.233527411214849 0.314457217600705 1 552.687 624.256 452.413 564.875 GeneID:6141,Genbank:NM_001270490.1,HGNC:HGNC:10310,MIM:604179 ribosomal protein L18 GO:0000184,GO:0003723,GO:0003735,GO:0005634,GO:0005730,GO:0005783,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleus|nucleolus|endoplasmic reticulum|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit hsa03010 Ribosome RPL18A 14050.8006777803 15134.6255800864 12966.9757754742 0.856775458821771 -0.223010938262306 0.234468937627317 1 1068.89 1183.11 903.736 1057.75 GeneID:6142,Genbank:NM_000980.3,HGNC:HGNC:10311,MIM:604178 ribosomal protein L18a GO:0000184,GO:0003723,GO:0003735,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0097327 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|response to antineoplastic agent hsa03010 Ribosome RPL19 25532.619413725 26464.394403071 24600.844424379 0.929582746149077 -0.10534480355044 0.446738976419758 1 920.054 946.242 830.179 926.416 GeneID:6143,Genbank:NM_000981.3,HGNC:HGNC:10312,MIM:180466 ribosomal protein L19 GO:0003723,GO:0003735,GO:0005925,GO:0006412,GO:0016020,GO:0022625,GO:0070180,GO:0097421,GO:1990932 RNA binding|structural constituent of ribosome|focal adhesion|translation|membrane|cytosolic large ribosomal subunit|large ribosomal subunit rRNA binding|liver regeneration|5.8S rRNA binding hsa03010 Ribosome RPL21 7643.54250158977 8323.70548846675 6963.3795147128 0.836572068096498 -0.25743826555398 0.149869284089538 1 564.635 633.984 452.974 537.133 GeneID:6144,Genbank:NM_000982.3,HGNC:HGNC:10313,MIM:603636 ribosomal protein L21 GO:0000184,GO:0003723,GO:0003735,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit hsa03010 Ribosome RPL22 7834.86451610843 8246.58431021149 7423.14472200537 0.900147799715515 -0.151766190767246 0.517186068982272 1 174.552 154.201 132.118 164.049 GeneID:6146,Genbank:NM_000983.3,HGNC:HGNC:10315,MIM:180474 ribosomal protein L22 GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005634,GO:0005737,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008201,GO:0019083,GO:0022625,GO:0030529,GO:0031012,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|nucleus|cytoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|heparin binding|viral transcription|cytosolic large ribosomal subunit|intracellular ribonucleoprotein complex|extracellular matrix|extracellular exosome hsa03010 Ribosome RPL22L1 636.03906538499 734.680245762128 537.397885007852 0.731471804377123 -0.451125840187687 0.00645289613037225 0.317998721304745 13.9791 13.8476 9.04958 11.5044 GeneID:200916,Genbank:NM_001320451.1,HGNC:HGNC:27610 ribosomal protein L22 like 1 GO:0002181,GO:0003723,GO:0003735,GO:0022625 cytoplasmic translation|RNA binding|structural constituent of ribosome|cytosolic large ribosomal subunit hsa03010 Ribosome RPL23 12851.6020196809 13746.1988757674 11957.0051635945 0.869840839031729 -0.201176649955901 0.237964565594001 1 929.327 975.956 765.215 908.302 GeneID:9349,Genbank:NM_000978.3,HGNC:HGNC:10316,MIM:603662 ribosomal protein L23 GO:0003735,GO:0005840,GO:0006412 structural constituent of ribosome|ribosome|translation hsa03010 Ribosome RPL23A 13839.4206520124 14652.1626024868 13026.678701538 0.889061843971556 -0.169644317128359 0.189611646596274 1 512.746 520.708 451.643 473.558 GeneID:6147,Genbank:NM_000984.5,HGNC:HGNC:10317,MIM:602326 ribosomal protein L23a GO:0000027,GO:0003723,GO:0003735,GO:0005634,GO:0005730,GO:0005737,GO:0006412,GO:0008283,GO:0022625,GO:0045296,GO:0070062,GO:0070180 ribosomal large subunit assembly|RNA binding|structural constituent of ribosome|nucleus|nucleolus|cytoplasm|translation|cell proliferation|cytosolic large ribosomal subunit|cadherin binding|extracellular exosome|large ribosomal subunit rRNA binding hsa03010 Ribosome RPL24 7113.42562509942 7874.6739501117 6352.17730008716 0.806659087135545 -0.309969009010545 0.139089924160148 1 523.257 581.378 393.362 501.689 GeneID:6152,Genbank:NM_000986.3,HGNC:HGNC:10325,MIM:604180 ribosomal protein L24 GO:0000027,GO:0003723,GO:0003735,GO:0005737,GO:0006412,GO:0007093,GO:0010458,GO:0016020,GO:0021554,GO:0022625,GO:0022626,GO:0031290,GO:0045296,GO:0060041,GO:0070062,GO:1902626 ribosomal large subunit assembly|RNA binding|structural constituent of ribosome|cytoplasm|translation|mitotic cell cycle checkpoint|exit from mitosis|membrane|optic nerve development|cytosolic large ribosomal subunit|cytosolic ribosome|retinal ganglion cell axon guidance|cadherin binding|retina development in camera-type eye|extracellular exosome|assembly of large subunit precursor of preribosome hsa03010 Ribosome RPL26 11168.8374266055 12323.131350742 10014.543502469 0.81266223798434 -0.299272236849298 0.133172754822089 1 373.856 383.326 267.74 342.283 GeneID:6154,Genbank:NM_000987.4,HGNC:HGNC:10327,MIM:603704 ribosomal protein L26 GO:0003735,GO:0005654,GO:0005730,GO:0006364,GO:0006412,GO:0006977,GO:0015934,GO:0022626,GO:0042273,GO:0045727,GO:0048027,GO:0071480,GO:1902164,GO:1902167,GO:1904803 structural constituent of ribosome|nucleoplasm|nucleolus|rRNA processing|translation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|large ribosomal subunit|cytosolic ribosome|ribosomal large subunit biogenesis|positive regulation of translation|mRNA 5'-UTR binding|cellular response to gamma radiation|positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of translation involved in cellular response to UV hsa03010 Ribosome RPL26L1 449.800900989166 375.272922034625 524.328879943707 1.39719348015024 0.482531815683331 0.00802425289261272 0.353067127274959 5.64872 6.70458 8.4437 8.87816 GeneID:51121,Genbank:XM_011534565.2,HGNC:HGNC:17050 ribosomal protein L26 like 1 GO:0002181,GO:0003723,GO:0003735,GO:0022625,GO:0042273,GO:0070062 cytoplasmic translation|RNA binding|structural constituent of ribosome|cytosolic large ribosomal subunit|ribosomal large subunit biogenesis|extracellular exosome hsa03010 Ribosome RPL27 13164.0670323844 14650.9609956783 11677.1730690905 0.797024377618302 -0.327304244032739 0.339470935537288 1 481.005 565.701 337.3 501.536 GeneID:6155,Genbank:NM_001349921.1,HGNC:HGNC:10328,MIM:607526 ribosomal protein L27 GO:0003735,GO:0006364,GO:0006412,GO:0015934,GO:0022625,GO:0098556 structural constituent of ribosome|rRNA processing|translation|large ribosomal subunit|cytosolic large ribosomal subunit|cytoplasmic side of rough endoplasmic reticulum membrane hsa03010 Ribosome RPL27A 17229.473616419 18974.2360710454 15484.7111617927 0.816091414896132 -0.293197329417895 0.086018414019344 0.964561165794104 143.857 157.219 112.702 135.065 GeneID:6157,Genbank:NM_000990.4,HGNC:HGNC:10329,MIM:603637 ribosomal protein L27a GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005783,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|endoplasmic reticulum|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit hsa03010 Ribosome RPL28 9725.14225412245 9939.65923210946 9510.62527613543 0.956836150419718 -0.0636561975691326 0.683893868618266 1 30.8595 34.9224 31.155 33.5098 GeneID:6158,Genbank:XM_024451636.1,HGNC:HGNC:10330,MIM:603638 ribosomal protein L28 GO:0000184,GO:0003723,GO:0003735,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0030425,GO:0036464,GO:0044297,GO:0070062,GO:1903146,GO:1903955 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|dendrite|cytoplasmic ribonucleoprotein granule|cell body|extracellular exosome|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion hsa03010 Ribosome RPL29 14387.1792201236 15625.1274788082 13149.230961439 0.841543915675109 -0.2488895348312 0.099263351772588 1 392.269 428.356 317.258 371.313 GeneID:6159,Genbank:XM_024453698.1,HGNC:HGNC:10331,MIM:601832 ribosomal protein L29 GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0007566,GO:0008201,GO:0016020,GO:0019083,GO:0022625,GO:0045296 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|embryo implantation|heparin binding|membrane|viral transcription|cytosolic large ribosomal subunit|cadherin binding hsa03010 Ribosome RPL3 21360.0459113446 21991.7986808775 20728.2931418117 0.942546512115698 -0.085364281659418 0.555981993118373 1 550.086 564.01 501.464 567.547 GeneID:6122,Genbank:NM_001033853.1,HGNC:HGNC:10332,MIM:604163 ribosomal protein L3 GO:0000027,GO:0000184,GO:0003723,GO:0003735,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008097,GO:0019083,GO:0022625,GO:0043234,GO:0070062,GO:0071353 ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleus|nucleolus|cytoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|5S rRNA binding|viral transcription|cytosolic large ribosomal subunit|protein complex|extracellular exosome|cellular response to interleukin-4 hsa03010 Ribosome RPL30 10869.5366280845 11492.2777336867 10246.7955224824 0.891624424673144 -0.165491957347369 0.391247080660486 1 793.663 858.029 668.436 805.415 GeneID:6156,Genbank:NM_000989.3,HGNC:HGNC:10333,MIM:180467 ribosomal protein L30 GO:0003735,GO:0005840,GO:0006412 structural constituent of ribosome|ribosome|translation hsa03010 Ribosome RPL31 4852.80760458203 5233.94442706429 4471.67078209978 0.854359621966398 -0.227084629703392 0.195076766631899 1 130.877 142.075 105.708 126.941 GeneID:6160,Genbank:NM_001098577.2,HGNC:HGNC:10334,MIM:617415 ribosomal protein L31 GO:0002181,GO:0003735,GO:0015934,GO:0022625,GO:0098556 cytoplasmic translation|structural constituent of ribosome|large ribosomal subunit|cytosolic large ribosomal subunit|cytoplasmic side of rough endoplasmic reticulum membrane hsa03010 Ribosome RPL32 19475.6902640006 20858.2997788275 18093.0807491736 0.867428359023742 -0.205183484573004 0.176261044529879 1 281.765 318.374 249.97 287.831 GeneID:6161,Genbank:NM_000994.3,HGNC:HGNC:10336 ribosomal protein L32 GO:0003735,GO:0006412,GO:0015934,GO:0022625,GO:0098556 structural constituent of ribosome|translation|large ribosomal subunit|cytosolic large ribosomal subunit|cytoplasmic side of rough endoplasmic reticulum membrane hsa03010 Ribosome RPL34 2700.15686740284 2984.7876948325 2415.52603997318 0.809279013095344 -0.305290912119314 0.167188986020927 1 93.6369 99.5259 69.9364 89.3691 GeneID:6164,Genbank:NM_000995.4,HGNC:HGNC:10340,MIM:616862 ribosomal protein L34 GO:0000184,GO:0003723,GO:0003735,GO:0005739,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022625,GO:0042254,GO:0045296,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|mitochondrion|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|ribosome biogenesis|cadherin binding|extracellular exosome hsa03010 Ribosome RPL35 10211.9570786653 11143.2238123335 9280.69034499716 0.832855060734324 -0.263862645339232 0.296799536189367 1 1123.8 1245.47 837.945 1131.16 GeneID:11224,Genbank:NM_007209.3,HGNC:HGNC:10344 ribosomal protein L35 GO:0000184,GO:0000463,GO:0003723,GO:0003729,GO:0003735,GO:0005730,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|mRNA binding|structural constituent of ribosome|nucleolus|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit hsa03010 Ribosome RPL35A 11692.2841338137 12652.144438893 10732.4238287343 0.848269151571063 -0.237405997519996 0.315271657294985 1 844.353 841.54 684.989 894.412 GeneID:6165,Genbank:NM_000996.3,HGNC:HGNC:10345,MIM:180468 ribosomal protein L35a hsa03010 Ribosome RPL36 9018.51304518674 9804.37620120904 8232.64988916445 0.839691350088059 -0.252068968812289 0.334082803223466 1 442.638 471.935 354.746 455.667 GeneID:25873,Genbank:NM_033643.2,HGNC:HGNC:13631,MIM:617893 ribosomal protein L36 GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005730,GO:0005737,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|nucleolus|cytoplasm|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit hsa03010 Ribosome RPL36A 87.018125766321 99.8764794482225 74.1597720844196 0.742514879320163 -0.429508158393048 0.180698217497849 1 13.4141 12.483 11.7493 13.8227 GeneID:6173,Genbank:NM_021029.5,HGNC:HGNC:10359,MIM:300902 ribosomal protein L36a GO:0003735,GO:0005634,GO:0006412,GO:0010033,GO:0022625,GO:0032526 structural constituent of ribosome|nucleus|translation|response to organic substance|cytosolic large ribosomal subunit|response to retinoic acid hsa03010 Ribosome RPL36AL 1668.38966092617 1783.07448800928 1553.70483384306 0.871362831049023 -0.198654520083809 0.178301192595784 1 179.518 144.078 145.549 141.377 GeneID:6166,Genbank:NM_001001.4,HGNC:HGNC:10346,MIM:180469 ribosomal protein L36a like GO:0003735,GO:0005634,GO:0005783,GO:0005829,GO:0005886,GO:0006412,GO:0022625 structural constituent of ribosome|nucleus|endoplasmic reticulum|cytosol|plasma membrane|translation|cytosolic large ribosomal subunit hsa03010 Ribosome RPL37 10335.0649922073 11014.1429285199 9655.98705589466 0.876689826758241 -0.189861588076684 0.378034056546085 1 275.149 316.832 231.292 287.374 GeneID:6167,Genbank:NM_000997.4,HGNC:HGNC:10347,MIM:604181 ribosomal protein L37 GO:0003723,GO:0003735,GO:0006412,GO:0019843,GO:0022625,GO:0046872 RNA binding|structural constituent of ribosome|translation|rRNA binding|cytosolic large ribosomal subunit|metal ion binding hsa03010 Ribosome RPL37A 10161.8103762343 10905.7509047931 9417.86984767551 0.863569132459859 -0.211616418505827 0.376467173566791 1 1473.86 1578.45 1131.21 1484.68 GeneID:6168,Genbank:NM_000998.4,HGNC:HGNC:10348,MIM:613314 ribosomal protein L37a GO:0003735,GO:0005840,GO:0006412,GO:0046872 structural constituent of ribosome|ribosome|translation|metal ion binding hsa03010 Ribosome RPL38 6189.9869976923 6826.40889302921 5553.5651023554 0.813541232202838 -0.29771262792367 0.169294649285917 1 968.789 1016.66 705.409 915.387 GeneID:6169,Genbank:NM_000999.3,HGNC:HGNC:10349,MIM:604182 ribosomal protein L38 GO:0001501,GO:0001503,GO:0003723,GO:0003735,GO:0005925,GO:0006412,GO:0006417,GO:0007605,GO:0022618,GO:0022625,GO:0033291,GO:0034463,GO:0042474,GO:0048318 skeletal system development|ossification|RNA binding|structural constituent of ribosome|focal adhesion|translation|regulation of translation|sensory perception of sound|ribonucleoprotein complex assembly|cytosolic large ribosomal subunit|eukaryotic 80S initiation complex|90S preribosome assembly|middle ear morphogenesis|axial mesoderm development hsa03010 Ribosome RPL39 8507.02349052772 8825.89200994895 8188.15497110649 0.927742483351987 -0.108203687754368 0.626327338500924 1 1109.11 1195.32 929.984 1176.22 GeneID:6170,Genbank:NM_001000.3,HGNC:HGNC:10350,MIM:300899 ribosomal protein L39 GO:0002227,GO:0003723,GO:0003735,GO:0005615,GO:0006412,GO:0019731,GO:0022625,GO:0050830,GO:0061844 innate immune response in mucosa|RNA binding|structural constituent of ribosome|extracellular space|translation|antibacterial humoral response|cytosolic large ribosomal subunit|defense response to Gram-positive bacterium|antimicrobial humoral immune response mediated by antimicrobial peptide hsa03010 Ribosome RPL39L 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:116832,Genbank:NM_052969.2,HGNC:HGNC:17094,MIM:607547 ribosomal protein L39 like GO:0003723,GO:0003735,GO:0006412,GO:0007283,GO:0022625 RNA binding|structural constituent of ribosome|translation|spermatogenesis|cytosolic large ribosomal subunit RPL3L 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0204097 0.0219108 0 GeneID:6123,Genbank:XM_011522571.2,HGNC:HGNC:10351,MIM:617416 ribosomal protein L3 like GO:0000027,GO:0003723,GO:0003735,GO:0005840,GO:0006412,GO:0016020,GO:0022625 ribosomal large subunit assembly|RNA binding|structural constituent of ribosome|ribosome|translation|membrane|cytosolic large ribosomal subunit hsa03010 Ribosome RPL4 34686.4073301782 36996.0442723787 32376.7703879777 0.875141411054861 -0.192411939035185 0.129755625292613 1 968.074 1027.58 831.422 916.251 GeneID:6124,Genbank:NM_000968.3,HGNC:HGNC:10353,MIM:180479 ribosomal protein L4 GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005634,GO:0005730,GO:0005737,GO:0005791,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0030529,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|nucleus|nucleolus|cytoplasm|rough endoplasmic reticulum|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|intracellular ribonucleoprotein complex|extracellular exosome hsa03010 Ribosome RPL41 12962.8002985219 13572.1227518723 12353.4778451716 0.910209704923822 -0.135729126060025 0.413211406997443 1 673.34 734.174 565.248 664.977 GeneID:6171,Genbank:NM_001035267.1,HGNC:HGNC:10354,MIM:613315 ribosomal protein L41 hsa03010 Ribosome RPL5 13520.8572895121 14943.6136974765 12098.1008815477 0.809583352893462 -0.304748470053964 0.040300521589288 0.758464027333929 518.227 523.76 384.893 446.551 GeneID:6125,Genbank:NM_000969.4,HGNC:HGNC:10360,MIM:603634 ribosomal protein L5 hsa03010 Ribosome RPL6 11945.733618082 12639.2973768851 11252.169859279 0.890252798376048 -0.167713029396579 0.200687914912092 1 137.797 130.376 117.96 122.755 GeneID:6128,Genbank:NM_001320141.1,HGNC:HGNC:10362,MIM:603703 ribosomal protein L6 GO:0000027,GO:0000184,GO:0002181,GO:0003677,GO:0003723,GO:0003735,GO:0005634,GO:0005829,GO:0005925,GO:0006355,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0036464,GO:0045296 ribosomal large subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|DNA binding|RNA binding|structural constituent of ribosome|nucleus|cytosol|focal adhesion|regulation of transcription, DNA-templated|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|cytoplasmic ribonucleoprotein granule|cadherin binding hsa03010 Ribosome RPL7 10243.9007007386 11153.899816266 9333.90158521114 0.836828529838439 -0.256996056932052 0.0498511665327346 0.815166074133459 347.783 336.006 278.197 298.848 GeneID:6129,Genbank:NM_000971.3,HGNC:HGNC:10363,MIM:604166 ribosomal protein L7 GO:0000184,GO:0000463,GO:0002181,GO:0003677,GO:0003723,GO:0003729,GO:0003735,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0030529,GO:0042273,GO:0042803,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|DNA binding|RNA binding|mRNA binding|structural constituent of ribosome|nucleus|nucleolus|cytoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|intracellular ribonucleoprotein complex|ribosomal large subunit biogenesis|protein homodimerization activity|extracellular exosome hsa03010 Ribosome RPL7A 19802.4391164642 21370.0103963567 18234.8678365717 0.853292417662114 -0.228887866571467 0.252347717790106 1 827.997 875.062 648.558 810.199 GeneID:6130,Genbank:NM_000972.2,HGNC:HGNC:10364,MIM:185640 ribosomal protein L7a GO:0000470,GO:0003723,GO:0005634,GO:0005730,GO:0005737,GO:0005840,GO:0005925,GO:0006412,GO:0016020,GO:0022625,GO:0042788,GO:0045296,GO:0070062,GO:1904401 maturation of LSU-rRNA|RNA binding|nucleus|nucleolus|cytoplasm|ribosome|focal adhesion|translation|membrane|cytosolic large ribosomal subunit|polysomal ribosome|cadherin binding|extracellular exosome|cellular response to Thyroid stimulating hormone hsa03010 Ribosome RPL7L1 6276.70371283782 6783.05904459119 5770.34838108445 0.850700007644151 -0.233277627824955 0.0761892801526258 0.94157495521624 53.3471 55.7166 46.6134 46.878 GeneID:285855,Genbank:XM_017010780.1,HGNC:HGNC:21370,MIM:617417 ribosomal protein L7 like 1 GO:0000463,GO:0001825,GO:0002181,GO:0003723,GO:0003735,GO:0005730,GO:0022625 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|blastocyst formation|cytoplasmic translation|RNA binding|structural constituent of ribosome|nucleolus|cytosolic large ribosomal subunit RPL8 27515.8714852434 28944.5171718005 26087.2257986863 0.901283847432841 -0.14994655955574 0.439040319975257 1 987.916 1040.59 863.244 1020.88 GeneID:6132,Genbank:NM_000973.4,HGNC:HGNC:10368,MIM:604177 ribosomal protein L8 GO:0002181,GO:0003723,GO:0003735,GO:0005925,GO:0016020,GO:0022625,GO:1990090,GO:1990932 cytoplasmic translation|RNA binding|structural constituent of ribosome|focal adhesion|membrane|cytosolic large ribosomal subunit|cellular response to nerve growth factor stimulus|5.8S rRNA binding hsa03010 Ribosome RPL9 9273.85702759369 10487.9155163782 8059.79853880916 0.768484311894271 -0.379912286348486 0.204729068378725 1 258.773 309.2 178.946 258.128 GeneID:6133,Genbank:NM_000661.4,HGNC:HGNC:10369,MIM:603686 ribosomal protein L9 GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005634,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0019843,GO:0022625,GO:0031012 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|nucleus|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|rRNA binding|cytosolic large ribosomal subunit|extracellular matrix hsa03010 Ribosome RPLP0 35942.8279257441 36687.913166414 35197.7426850742 0.95938252266951 -0.059821937073721 0.671965267643635 1 1020.01 1065.77 959.152 1084.78 GeneID:6175,Genbank:NM_001002.3,HGNC:HGNC:10371,MIM:180510 ribosomal protein lateral stalk subunit P0 GO:0000184,GO:0003723,GO:0003735,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0030529,GO:0035722,GO:0036464,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleus|cytoplasm|endoplasmic reticulum|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|intracellular ribonucleoprotein complex|interleukin-12-mediated signaling pathway|cytoplasmic ribonucleoprotein granule|extracellular exosome hsa03010 Ribosome RPLP1 23691.6634766739 23923.4767668895 23459.8501864582 0.980620434690623 -0.0282332693032794 0.872191461557255 1 3168.85 3329.25 2946.66 3538.91 GeneID:6176,Genbank:NM_001003.2,HGNC:HGNC:10372,MIM:180520 ribosomal protein lateral stalk subunit P1 GO:0000184,GO:0002181,GO:0003735,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006414,GO:0006614,GO:0019083,GO:0022625,GO:0030295,GO:0045860,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|structural constituent of ribosome|cytosol|focal adhesion|rRNA processing|translation|translational initiation|translational elongation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic large ribosomal subunit|protein kinase activator activity|positive regulation of protein kinase activity|extracellular exosome hsa03010 Ribosome RPLP2 7402.06351664997 7894.22471191189 6909.90232138805 0.87531107531832 -0.192132269870577 0.140094595769245 1 1032.59 1036.03 880.82 944.038 GeneID:6181,Genbank:NM_001004.3,HGNC:HGNC:10377,MIM:180530 ribosomal protein lateral stalk subunit P2 GO:0000184,GO:0002181,GO:0003735,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006414,GO:0006614,GO:0016020,GO:0019083,GO:0022625,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|structural constituent of ribosome|cytosol|focal adhesion|rRNA processing|translation|translational initiation|translational elongation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic large ribosomal subunit|extracellular exosome hsa03010 Ribosome RPN1 8936.73475311761 8614.20281561529 9259.26669061993 1.07488375753532 0.104180649121688 0.429712125451092 1 126.145 130.704 142.076 135.836 GeneID:6184,Genbank:NM_002950.3,HGNC:HGNC:10381,MIM:180470 ribophorin I GO:0003723,GO:0004579,GO:0005783,GO:0005789,GO:0005791,GO:0005829,GO:0006464,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0031012,GO:0042470 RNA binding|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|cytosol|cellular protein modification process|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|extracellular matrix|melanosome hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum RPN2 8650.24803848374 8734.11235361226 8566.38372335521 0.980796144649126 -0.0279747868481851 0.829026269184413 1 103.611 104.607 106.62 99.4838 GeneID:6185,Genbank:NM_001324301.1,HGNC:HGNC:10382,MIM:180490 ribophorin II GO:0000421,GO:0005789,GO:0005791,GO:0006464,GO:0006487,GO:0007568,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0042493,GO:0043022 autophagosome membrane|endoplasmic reticulum membrane|rough endoplasmic reticulum|cellular protein modification process|protein N-linked glycosylation|aging|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|response to drug|ribosome binding hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum RPP25 6.90767442217424 5.09281911831339 8.72252972603509 1.71271147146568 0.77628213113835 0.529086091635506 1 0.100342 0.129691 0.185512 0.217104 GeneID:54913,Genbank:NM_017793.2,HGNC:HGNC:30361 ribonuclease P and MRP subunit p25 GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005654,GO:0005815,GO:0006364,GO:0030681 ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|nucleoplasm|microtubule organizing center|rRNA processing|multimeric ribonuclease P complex hsa03008,hsa03013 Ribosome biogenesis in eukaryotes|RNA transport RPP25L 308.537951656109 306.961909064667 310.113994247551 1.01026865252594 0.014738988154142 0.975155025161135 1 12.5494 14.1231 11.198 15.7813 GeneID:138716,Genbank:NM_148178.2,HGNC:HGNC:19909 ribonuclease P/MRP subunit p25 like GO:0003723,GO:0005634 RNA binding|nucleus hsa03008,hsa03013 Ribosome biogenesis in eukaryotes|RNA transport RPP30 1054.15546802659 1076.53225991428 1031.7786761389 0.95842801424367 -0.0612580170822993 0.690508732785827 1 6.40915 6.60309 6.54278 6.19593 GeneID:10556,Genbank:NM_001104546.1,HGNC:HGNC:17688,MIM:606115 ribonuclease P/MRP subunit p30 GO:0000172,GO:0001682,GO:0003723,GO:0004526,GO:0005634,GO:0005654,GO:0005655,GO:0006364,GO:0008033,GO:0030681,GO:0090502 ribonuclease MRP complex|tRNA 5'-leader removal|RNA binding|ribonuclease P activity|nucleus|nucleoplasm|nucleolar ribonuclease P complex|rRNA processing|tRNA processing|multimeric ribonuclease P complex|RNA phosphodiester bond hydrolysis, endonucleolytic hsa03008,hsa03013 Ribosome biogenesis in eukaryotes|RNA transport RPP38 286.53512765159 302.19546521404 270.874790089141 0.896356237170154 -0.15785588106675 0.441113868784328 1 6.00032 5.68004 4.84747 5.79855 GeneID:10557,Genbank:NM_183005.4,HGNC:HGNC:30329,MIM:606116 ribonuclease P/MRP subunit p38 GO:0001650,GO:0001682,GO:0004526,GO:0005634,GO:0005654,GO:0005655,GO:0005730,GO:0006364 fibrillar center|tRNA 5'-leader removal|ribonuclease P activity|nucleus|nucleoplasm|nucleolar ribonuclease P complex|nucleolus|rRNA processing hsa03008,hsa03013 Ribosome biogenesis in eukaryotes|RNA transport RPP40 289.017966359982 301.321183614603 276.714749105362 0.918338185805371 -0.122902558746303 0.543394850737103 1 3.00823 3.06653 2.52502 2.77743 GeneID:10799,Genbank:XM_024446309.1,HGNC:HGNC:20992,MIM:606117 ribonuclease P/MRP subunit p40 GO:0001682,GO:0004526,GO:0005634,GO:0005654,GO:0005655,GO:0006364 tRNA 5'-leader removal|ribonuclease P activity|nucleus|nucleoplasm|nucleolar ribonuclease P complex|rRNA processing hsa03008,hsa03013 Ribosome biogenesis in eukaryotes|RNA transport RPRD1A 631.180722740681 703.036310043 559.325135438362 0.795584989634677 -0.3299120379011 0.148729775304067 1 4.5365 4.1543 4.17489 2.9836 GeneID:55197,Genbank:NM_018170.4,HGNC:HGNC:25560,MIM:610347 regulation of nuclear pre-mRNA domain containing 1A GO:0005654,GO:0016591,GO:0042795,GO:0042802,GO:0070940 nucleoplasm|DNA-directed RNA polymerase II, holoenzyme|snRNA transcription from RNA polymerase II promoter|identical protein binding|dephosphorylation of RNA polymerase II C-terminal domain RPRD1B 785.008008581475 797.504420761185 772.511596401765 0.968661209005506 -0.0459359262048478 0.774584276643646 1 4.74553 4.93481 5.00834 4.52247 GeneID:58490,Genbank:XM_017027991.1,HGNC:HGNC:16209,MIM:614694 regulation of nuclear pre-mRNA domain containing 1B GO:0000993,GO:0005634,GO:0005654,GO:0005813,GO:0005829,GO:0008284,GO:0010564,GO:0016591,GO:0042795,GO:0042802,GO:0045944,GO:0070940 RNA polymerase II core binding|nucleus|nucleoplasm|centrosome|cytosol|positive regulation of cell proliferation|regulation of cell cycle process|DNA-directed RNA polymerase II, holoenzyme|snRNA transcription from RNA polymerase II promoter|identical protein binding|positive regulation of transcription from RNA polymerase II promoter|dephosphorylation of RNA polymerase II C-terminal domain RPRD2 979.587951971442 1055.77677324355 903.399130699335 0.855672480768751 -0.224869401986149 0.142270094729168 1 4.56264 4.62196 4.31673 3.6261 GeneID:23248,Genbank:NM_015203.4,HGNC:HGNC:29039,MIM:614695 regulation of nuclear pre-mRNA domain containing 2 GO:0005654,GO:0016591,GO:0042795 nucleoplasm|DNA-directed RNA polymerase II, holoenzyme|snRNA transcription from RNA polymerase II promoter RPRM 520.792783712865 477.503705943264 564.081861482466 1.18131410177891 0.240392616579752 0.17048887954741 1 21.2905 22 25.3282 26.5385 GeneID:56475,Genbank:NM_019845.2,HGNC:HGNC:24201,MIM:612171 reprimo, TP53 dependent G2 arrest mediator homolog hsa04115 p53 signaling pathway RPRML 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0975612 0 0 0.0824964 GeneID:388394,Genbank:NM_203400.4,HGNC:HGNC:32422 reprimo like GO:0016021 integral component of membrane RPS10 157.175136624023 163.15250822966 151.197765018387 0.926726574166756 -0.109784352887818 0.655698517868109 1 371.939 399.749 285.84 396.535 GeneID:6204,Genbank:NM_001014.4,HGNC:HGNC:10383,MIM:603632 ribosomal protein S10 GO:0000028,GO:0000184,GO:0003723,GO:0003735,GO:0005654,GO:0005730,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0031012,GO:0070062 ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleoplasm|nucleolus|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|extracellular matrix|extracellular exosome hsa03010 Ribosome RPS11 20865.6472712581 21801.1497855662 19930.1447569501 0.914178607687249 -0.129452035456044 0.512070646500049 1 1273.56 1410.52 1120.2 1348.28 GeneID:6205,Genbank:NM_001015.4,HGNC:HGNC:10384,MIM:180471 ribosomal protein S11 GO:0003735,GO:0006412,GO:0019843,GO:0022627,GO:0031012 structural constituent of ribosome|translation|rRNA binding|cytosolic small ribosomal subunit|extracellular matrix hsa03010 Ribosome RPS12 12471.0791974009 13475.4407088678 11466.717685934 0.850934521079383 -0.232879973256406 0.30376278403397 1 1442.88 1607.05 1139.74 1469.61 GeneID:6206,Genbank:NM_001016.3,HGNC:HGNC:10385,MIM:603660 ribosomal protein S12 GO:0003735,GO:0006412,GO:0022627 structural constituent of ribosome|translation|cytosolic small ribosomal subunit hsa03010 Ribosome RPS13 4703.41649592835 5148.93378580906 4257.89920604765 0.826947749412279 -0.274131919112612 0.169218865672138 1 558.037 589.483 405.38 516.287 GeneID:6207,Genbank:NM_001017.2,HGNC:HGNC:10386,MIM:180476 ribosomal protein S13 GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0031012,GO:0033119,GO:0048027,GO:0070062,GO:0070181 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|nucleus|nucleoplasm|nucleolus|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|extracellular matrix|negative regulation of RNA splicing|mRNA 5'-UTR binding|extracellular exosome|small ribosomal subunit rRNA binding hsa03010 Ribosome RPS14 12469.2445256121 13394.6898737536 11543.7991774707 0.861819070562458 -0.214543071744851 0.355739277707639 1 429.662 506.158 353.647 451.665 GeneID:6208,Genbank:NM_005617.3,HGNC:HGNC:10387,MIM:130620 ribosomal protein S14 GO:0000028,GO:0000122,GO:0000184,GO:0000462,GO:0003723,GO:0003735,GO:0005654,GO:0005730,GO:0005739,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0030218,GO:0030490,GO:0031012,GO:0045182,GO:0048027,GO:0070062,GO:0070181 ribosomal small subunit assembly|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|nucleoplasm|nucleolus|mitochondrion|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|erythrocyte differentiation|maturation of SSU-rRNA|extracellular matrix|translation regulator activity|mRNA 5'-UTR binding|extracellular exosome|small ribosomal subunit rRNA binding hsa03010 Ribosome RPS15 10757.4299951205 11400.1209861585 10114.7390040826 0.88724839116738 -0.172590041613481 0.315755467312073 1 800.511 843.455 692.438 794.542 GeneID:6209,Genbank:NM_001018.4,HGNC:HGNC:10388,MIM:180535 ribosomal protein S15 GO:0000028,GO:0003723,GO:0003735,GO:0006412,GO:0022627,GO:0098556 ribosomal small subunit assembly|RNA binding|structural constituent of ribosome|translation|cytosolic small ribosomal subunit|cytoplasmic side of rough endoplasmic reticulum membrane hsa03010 Ribosome RPS15A 6091.09396668199 6850.3442838377 5331.84364952628 0.778332216397637 -0.361542021105806 0.258645273631655 1 476.037 581.158 339.625 497.593 GeneID:6210,Genbank:NM_001030009.1,HGNC:HGNC:10389,MIM:603674 ribosomal protein S15a GO:0000184,GO:0003723,GO:0003735,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008284,GO:0009615,GO:0016020,GO:0019083,GO:0022627,GO:0031012,GO:0045787,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleoplasm|cytoplasm|mitochondrion|cytosol|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|positive regulation of cell proliferation|response to virus|membrane|viral transcription|cytosolic small ribosomal subunit|extracellular matrix|positive regulation of cell cycle|extracellular exosome hsa03010 Ribosome RPS16 12782.4503466282 13402.7163636311 12162.1843296254 0.907441745363506 -0.140123064861926 0.546002382367109 1 478.656 530.37 431.188 525.421 GeneID:6217,Genbank:NM_001321111.1,HGNC:HGNC:10396,MIM:603675 ribosomal protein S16 GO:0000184,GO:0000462,GO:0003723,GO:0003735,GO:0005654,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0015935,GO:0016020,GO:0019083,GO:0022627,GO:0031012,GO:0042274,GO:0070062,GO:0097421,GO:1990830 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|nucleoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|small ribosomal subunit|membrane|viral transcription|cytosolic small ribosomal subunit|extracellular matrix|ribosomal small subunit biogenesis|extracellular exosome|liver regeneration|cellular response to leukemia inhibitory factor hsa03010 Ribosome RPS17 20520.4936292149 22035.0112081441 19005.9760502857 0.862535347531894 -0.213344513861042 0.335519687589367 1 1554.35 1631.3 1198.19 1555.71 GeneID:6218,Genbank:NM_001021.5,HGNC:HGNC:10397,MIM:180472 ribosomal protein S17 hsa03010 Ribosome RPS18 20823.3761950727 23107.9563911163 18538.795999029 0.802268953829084 -0.317842125902609 0.0931496359233595 0.988657766036134 1557.11 1649.54 1145.16 1342.7 GeneID:6222,Genbank:NM_022551.2,HGNC:HGNC:10401,MIM:180473 ribosomal protein S18 GO:0003723,GO:0003735,GO:0005634,GO:0005925,GO:0006412,GO:0015935,GO:0016020,GO:0019843,GO:0019901,GO:0022627,GO:0031012,GO:0042254,GO:0070062 RNA binding|structural constituent of ribosome|nucleus|focal adhesion|translation|small ribosomal subunit|membrane|rRNA binding|protein kinase binding|cytosolic small ribosomal subunit|extracellular matrix|ribosome biogenesis|extracellular exosome hsa03010 Ribosome RPS19 13046.7620676962 14061.2728629564 12032.251272436 0.855701428292051 -0.224820596230618 0.337141688337865 1 108.607 120.128 91.6226 114.17 GeneID:6223,Genbank:NM_001321485.1,HGNC:HGNC:10402,MIM:603474 ribosomal protein S19 hsa03010 Ribosome RPS19BP1 1779.18741952925 1752.29131858451 1806.08352047399 1.03069820715253 0.0436219672540605 0.779413009908485 1 75.7974 78.0199 76.9337 85.0185 GeneID:91582,Genbank:NM_194326.3,HGNC:HGNC:28749,MIM:610225 ribosomal protein S19 binding protein 1 GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0019899 RNA binding|nucleus|nucleoplasm|nucleolus|cytosol|enzyme binding RPS2 49486.5693102644 51156.5378803049 47816.6007402239 0.934711431256436 -0.0974070571088623 0.544332258910913 1 2492.95 2700.24 2350.53 2609.42 GeneID:6187,Genbank:NM_002952.3,HGNC:HGNC:10404,MIM:603624 ribosomal protein S2 GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006479,GO:0006614,GO:0016020,GO:0017134,GO:0019083,GO:0019899,GO:0022627,GO:0045296,GO:0051347,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|nucleus|nucleoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|protein methylation|SRP-dependent cotranslational protein targeting to membrane|membrane|fibroblast growth factor binding|viral transcription|enzyme binding|cytosolic small ribosomal subunit|cadherin binding|positive regulation of transferase activity|extracellular exosome hsa03010 Ribosome RPS20 13822.6589704744 14264.4630793191 13380.8548616298 0.938055276754835 -0.0922551559949065 0.676425481746976 1 402.574 464.397 361.391 458.602 GeneID:6224,Genbank:NM_001146227.1,HGNC:HGNC:10405,MIM:603682 ribosomal protein S20 GO:0002181,GO:0003723,GO:0003735,GO:0016020,GO:0022627,GO:0031012,GO:0070062 cytoplasmic translation|RNA binding|structural constituent of ribosome|membrane|cytosolic small ribosomal subunit|extracellular matrix|extracellular exosome hsa03010 Ribosome RPS21 4986.40170736755 5302.15669783575 4670.64671689934 0.880895639845163 -0.182956982434012 0.49310803395372 1 103.404 117.922 84.672 115.872 GeneID:6227,Genbank:XM_024451959.1,HGNC:HGNC:10409,MIM:180477 ribosomal protein S21 GO:0000447,GO:0000461,GO:0002181,GO:0003735,GO:0022627,GO:0042788,GO:0043022,GO:0098556 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|structural constituent of ribosome|cytosolic small ribosomal subunit|polysomal ribosome|ribosome binding|cytoplasmic side of rough endoplasmic reticulum membrane hsa03010 Ribosome RPS23 14995.2887596036 16439.1296141008 13551.4479051064 0.824340961061744 -0.278686911496697 0.0570746621463017 0.86572937197041 186.097 203.839 149.276 173.518 GeneID:6228,Genbank:NM_001025.4,HGNC:HGNC:10410,MIM:603683 ribosomal protein S23 GO:0002181,GO:0003723,GO:0003735,GO:0005840,GO:0006412,GO:0015935,GO:0016020,GO:0022627,GO:0034063,GO:0042788,GO:0045182,GO:1990145 cytoplasmic translation|RNA binding|structural constituent of ribosome|ribosome|translation|small ribosomal subunit|membrane|cytosolic small ribosomal subunit|stress granule assembly|polysomal ribosome|translation regulator activity|maintenance of translational fidelity hsa03010 Ribosome RPS24 16319.1724486482 17849.3696944284 14788.975202868 0.82854327385489 -0.271351045182973 0.0743992836938898 0.938990486715004 187.53 184.043 145.724 171.471 GeneID:6229,Genbank:NM_001142285.1,HGNC:HGNC:10411,MIM:602412 ribosomal protein S24 GO:0000462,GO:0003723,GO:0003735,GO:0005634,GO:0005840,GO:0006364,GO:0006413,GO:0015935,GO:0016020,GO:0022627,GO:0031369,GO:0032403,GO:0034101,GO:0042274,GO:0097421 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|nucleus|ribosome|rRNA processing|translational initiation|small ribosomal subunit|membrane|cytosolic small ribosomal subunit|translation initiation factor binding|protein complex binding|erythrocyte homeostasis|ribosomal small subunit biogenesis|liver regeneration hsa03010 Ribosome RPS25 8197.10684357944 8632.19239566452 7762.02129149437 0.899194658287831 -0.153294629707244 0.35493949056264 1 669.444 710.722 579.002 689.171 GeneID:6230,Genbank:NM_001028.2,HGNC:HGNC:10413,MIM:180465 ribosomal protein S25 GO:0005840 ribosome hsa03010 Ribosome RPS26 3528.69078233027 3617.79792267542 3439.58364198513 0.950739570175194 -0.0728778876305589 0.670128715338118 1 142.935 163.022 133.525 157.553 GeneID:6231,Genbank:NM_001029.4,HGNC:HGNC:10414,MIM:603701 ribosomal protein S26 GO:0002181,GO:0003735,GO:0022627,GO:0042788,GO:0098556 cytoplasmic translation|structural constituent of ribosome|cytosolic small ribosomal subunit|polysomal ribosome|cytoplasmic side of rough endoplasmic reticulum membrane hsa03010 Ribosome RPS27 11077.9958609246 11532.3546764401 10623.6370454091 0.921202767645756 -0.118409349341918 0.416278652300362 1 456.381 482.167 416.873 478.069 GeneID:6232,Genbank:NM_001349947.1,HGNC:HGNC:10416,MIM:603702 ribosomal protein S27 hsa03010 Ribosome RPS27A 7024.60924624422 7728.99828221652 6320.22021027193 0.817728246209341 -0.29030661967237 0.144994419238045 1 200.836 220.009 153.833 192.74 GeneID:6233,Genbank:NM_001135592.2,HGNC:HGNC:10417,MIM:191343 ribosomal protein S27a GO:0000086,GO:0000122,GO:0000165,GO:0000184,GO:0000187,GO:0000209,GO:0000715,GO:0000717,GO:0002223,GO:0002755,GO:0002756,GO:0003723,GO:0003735,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005741,GO:0005789,GO:0005829,GO:0005886,GO:0005978,GO:0006283,GO:0006294,GO:0006296,GO:0006297,GO:0006364,GO:0006412,GO:0006413,GO:0006457,GO:0006614,GO:0006879,GO:0006977,GO:0007179,GO:0007219,GO:0007249,GO:0007254,GO:0008543,GO:0010008,GO:0010803,GO:0010972,GO:0015935,GO:0016020,GO:0016055,GO:0016197,GO:0016236,GO:0016567,GO:0016579,GO:0019058,GO:0019068,GO:0019083,GO:0019221,GO:0019985,GO:0022627,GO:0030512,GO:0030666,GO:0031145,GO:0031146,GO:0031982,GO:0032479,GO:0032480,GO:0033209,GO:0033683,GO:0034220,GO:0035635,GO:0035666,GO:0036297,GO:0038061,GO:0038095,GO:0038128,GO:0042059,GO:0042276,GO:0042769,GO:0042787,GO:0043065,GO:0043066,GO:0043123,GO:0043161,GO:0043209,GO:0043488,GO:0043657,GO:0044267,GO:0044322,GO:0045087,GO:0045742,GO:0045746,GO:0045944,GO:0046872,GO:0050852,GO:0051092,GO:0051403,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0060544,GO:0061024,GO:0061418,GO:0070062,GO:0070423,GO:0070498,GO:0070911,GO:0070987,GO:0075733,GO:0090090,GO:0090263,GO:1901796,GO:1902036,GO:1904380 G2/M transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|MAPK cascade|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|activation of MAPK activity|protein polyubiquitination|nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA duplex unwinding|stimulatory C-type lectin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|RNA binding|structural constituent of ribosome|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|mitochondrial outer membrane|endoplasmic reticulum membrane|cytosol|plasma membrane|glycogen biosynthetic process|transcription-coupled nucleotide-excision repair|nucleotide-excision repair, preincision complex assembly|nucleotide-excision repair, DNA incision, 5'-to lesion|nucleotide-excision repair, DNA gap filling|rRNA processing|translation|translational initiation|protein folding|SRP-dependent cotranslational protein targeting to membrane|cellular iron ion homeostasis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|transforming growth factor beta receptor signaling pathway|Notch signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|fibroblast growth factor receptor signaling pathway|endosome membrane|regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of G2/M transition of mitotic cell cycle|small ribosomal subunit|membrane|Wnt signaling pathway|endosomal transport|macroautophagy|protein ubiquitination|protein deubiquitination|viral life cycle|virion assembly|viral transcription|cytokine-mediated signaling pathway|translesion synthesis|cytosolic small ribosomal subunit|negative regulation of transforming growth factor beta receptor signaling pathway|endocytic vesicle membrane|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|vesicle|regulation of type I interferon production|negative regulation of type I interferon production|tumor necrosis factor-mediated signaling pathway|nucleotide-excision repair, DNA incision|ion transmembrane transport|entry of bacterium into host cell|TRIF-dependent toll-like receptor signaling pathway|interstrand cross-link repair|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|ERBB2 signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|error-prone translesion synthesis|DNA damage response, detection of DNA damage|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|myelin sheath|regulation of mRNA stability|host cell|cellular protein metabolic process|endoplasmic reticulum quality control compartment|innate immune response|positive regulation of epidermal growth factor receptor signaling pathway|negative regulation of Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of necroptotic process|membrane organization|regulation of transcription from RNA polymerase II promoter in response to hypoxia|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|global genome nucleotide-excision repair|error-free translesion synthesis|intracellular transport of virus|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of signal transduction by p53 class mediator|regulation of hematopoietic stem cell differentiation|endoplasmic reticulum mannose trimming hsa03010 Ribosome RPS27L 1842.9884637281 1969.03983806773 1716.93708938846 0.871966659178077 -0.197655122222353 0.170397655375677 1 101.844 94.1021 79.9791 87.1322 GeneID:51065,Genbank:NM_015920.3,HGNC:HGNC:18476,MIM:612055 ribosomal protein S27 like GO:0000028,GO:0003723,GO:0003735,GO:0005634,GO:0006281,GO:0006412,GO:0006919,GO:0006978,GO:0008494,GO:0008656,GO:0022627,GO:0031571,GO:0042771,GO:0045727,GO:0046872 ribosomal small subunit assembly|RNA binding|structural constituent of ribosome|nucleus|DNA repair|translation|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|translation activator activity|cysteine-type endopeptidase activator activity involved in apoptotic process|cytosolic small ribosomal subunit|mitotic G1 DNA damage checkpoint|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of translation|metal ion binding hsa03010 Ribosome RPS28 6617.31309079264 6855.52131284856 6379.10486873672 0.930506168331948 -0.103912380935643 0.571168509309211 1 1209.92 1337.69 1127.94 1294.41 GeneID:6234,Genbank:NM_001031.4,HGNC:HGNC:10418,MIM:603685 ribosomal protein S28 GO:0000028,GO:0002181,GO:0003723,GO:0003735,GO:0022627,GO:0030490,GO:0042254,GO:0042788,GO:0098556 ribosomal small subunit assembly|cytoplasmic translation|RNA binding|structural constituent of ribosome|cytosolic small ribosomal subunit|maturation of SSU-rRNA|ribosome biogenesis|polysomal ribosome|cytoplasmic side of rough endoplasmic reticulum membrane hsa03010 Ribosome RPS29 2268.94584766368 2445.61651248604 2092.27518284131 0.855520549587088 -0.225125586249443 0.431640269000349 1 10.3603 12.569 8.06161 11.4148 GeneID:6235,Genbank:NM_001030001.3,HGNC:HGNC:10419,MIM:603633 ribosomal protein S29 GO:0003735,GO:0006412,GO:0015934,GO:0022625,GO:0098556 structural constituent of ribosome|translation|large ribosomal subunit|cytosolic large ribosomal subunit|cytoplasmic side of rough endoplasmic reticulum membrane hsa03010 Ribosome RPS3 10675.8101612897 11785.1581356135 9566.46218696591 0.811738126623608 -0.300913717669213 0.259185676186503 1 127.344 148.449 94.8051 131.655 GeneID:6188,Genbank:NM_001256802.1,HGNC:HGNC:10420,MIM:600454 ribosomal protein S3 hsa03010 Ribosome RPS3A 10417.3712547268 11849.1220815474 8985.62042790624 0.758336386954739 -0.399090146044211 0.0851667119812034 0.964561165794104 155.253 180.878 109.464 145.53 GeneID:6189,Genbank:NM_001006.4,HGNC:HGNC:10421,MIM:180478 ribosomal protein S3A GO:0000184,GO:0002181,GO:0003723,GO:0003735,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0019083,GO:0022627,GO:0030154,GO:0030529,GO:0031012,GO:0043066,GO:0048027,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytoplasmic translation|RNA binding|structural constituent of ribosome|nucleus|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|viral transcription|cytosolic small ribosomal subunit|cell differentiation|intracellular ribonucleoprotein complex|extracellular matrix|negative regulation of apoptotic process|mRNA 5'-UTR binding|extracellular exosome hsa03010 Ribosome RPS4X 22663.9322547066 24450.3342612538 20877.5302481593 0.853875044205171 -0.227903133115882 0.187444777218816 1 857.56 906.289 695.29 830.586 GeneID:6191,Genbank:NM_001007.4,HGNC:HGNC:10424,MIM:312760 ribosomal protein S4, X-linked GO:0003735,GO:0005840,GO:0006412,GO:0019843,GO:0030529 structural constituent of ribosome|ribosome|translation|rRNA binding|intracellular ribonucleoprotein complex hsa03010 Ribosome RPS4Y1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0505688 0 0 0 GeneID:6192,Genbank:NM_001008.3,HGNC:HGNC:10425,MIM:470000 ribosomal protein S4, Y-linked 1 GO:0000184,GO:0003723,GO:0003735,GO:0005634,GO:0005654,GO:0005829,GO:0005844,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0007275,GO:0016020,GO:0019083,GO:0019843,GO:0022627 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleus|nucleoplasm|cytosol|polysome|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|multicellular organism development|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit hsa03010 Ribosome RPS5 11654.2703952962 12117.5273223408 11191.0134682515 0.923539363317041 -0.114754641473879 0.518434923972288 1 837.462 916.497 761.856 884.072 GeneID:6193,Genbank:NM_001009.3,HGNC:HGNC:10426,MIM:603630 ribosomal protein S5 GO:0000028,GO:0000184,GO:0003723,GO:0003729,GO:0003735,GO:0005654,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006450,GO:0006614,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0030529,GO:0031012,GO:0070062 ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|mRNA binding|structural constituent of ribosome|nucleoplasm|cytosol|focal adhesion|rRNA processing|translation|translational initiation|regulation of translational fidelity|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|intracellular ribonucleoprotein complex|extracellular matrix|extracellular exosome hsa03010 Ribosome RPS6 19973.9066124947 21769.5196594461 18178.2935655432 0.835034206078835 -0.260092797983868 0.0641902288065999 0.90091963811897 913.331 934.919 718.067 825.19 GeneID:6194,Genbank:NM_001010.2,HGNC:HGNC:10429,MIM:180460 ribosomal protein S6 GO:0003735,GO:0005634,GO:0006364,GO:0006412,GO:0022627,GO:0042274,GO:0042593,GO:0048471 structural constituent of ribosome|nucleus|rRNA processing|translation|cytosolic small ribosomal subunit|ribosomal small subunit biogenesis|glucose homeostasis|perinuclear region of cytoplasm hsa01521,hsa03010,hsa04066,hsa04150,hsa04151,hsa04371,hsa04714,hsa04910,hsa05205 EGFR tyrosine kinase inhibitor resistance|Ribosome|HIF-1 signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Apelin signaling pathway|Thermogenesis|Insulin signaling pathway|Proteoglycans in cancer RPS6KA1 1295.60265556243 1284.18623017355 1307.01908095132 1.0177800152667 0.0254257685060689 0.895527791991358 1 11.4834 12.9113 12.6037 12.6029 GeneID:6195,Genbank:NM_002953.3,HGNC:HGNC:10430,MIM:601684 ribosomal protein S6 kinase A1 hsa04010,hsa04114,hsa04150,hsa04714,hsa04720,hsa04722,hsa04914,hsa04931 MAPK signaling pathway|Oocyte meiosis|mTOR signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Progesterone-mediated oocyte maturation|Insulin resistance RPS6KA2 450.97230169034 437.213006779138 464.731596601543 1.06294092214943 0.0880614146577693 0.644781668472677 1 2.48508 2.82069 2.73268 2.87128 GeneID:6196,Genbank:NM_001318937.1,HGNC:HGNC:10431,MIM:601685 ribosomal protein S6 kinase A2 GO:0000287,GO:0004674,GO:0004712,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0008285,GO:0016301,GO:0035556,GO:0043065,GO:0045786 magnesium ion binding|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|negative regulation of cell proliferation|kinase activity|intracellular signal transduction|positive regulation of apoptotic process|negative regulation of cell cycle hsa04010,hsa04114,hsa04150,hsa04714,hsa04720,hsa04722,hsa04914,hsa04931 MAPK signaling pathway|Oocyte meiosis|mTOR signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Progesterone-mediated oocyte maturation|Insulin resistance RPS6KA3 623.524183460915 615.987930939931 631.060435981899 1.02446883174962 0.0348760927295716 0.859929480910332 1 2.96761 2.56062 3.28747 2.4173 GeneID:6197,Genbank:XM_017029716.1,HGNC:HGNC:10432,MIM:300075 ribosomal protein S6 kinase A3 GO:0000287,GO:0001501,GO:0002224,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007049,GO:0007165,GO:0007417,GO:0016301,GO:0018105,GO:0019901,GO:0030307,GO:0032496,GO:0035556,GO:0043027,GO:0043066,GO:0043154,GO:0043555,GO:0043620,GO:0045597,GO:0045944 magnesium ion binding|skeletal system development|toll-like receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cell cycle|signal transduction|central nervous system development|kinase activity|peptidyl-serine phosphorylation|protein kinase binding|positive regulation of cell growth|response to lipopolysaccharide|intracellular signal transduction|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of translation in response to stress|regulation of DNA-templated transcription in response to stress|positive regulation of cell differentiation|positive regulation of transcription from RNA polymerase II promoter hsa04010,hsa04114,hsa04150,hsa04714,hsa04720,hsa04722,hsa04914,hsa04931 MAPK signaling pathway|Oocyte meiosis|mTOR signaling pathway|Thermogenesis|Long-term potentiation|Neurotrophin signaling pathway|Progesterone-mediated oocyte maturation|Insulin resistance RPS6KA4 1101.81682711733 989.186931508851 1214.44672272582 1.22772216660138 0.295984115906199 0.0520180027992525 0.834789912658145 15.2526 15.7869 19.2709 19.2825 GeneID:8986,Genbank:NM_003942.2,HGNC:HGNC:10433,MIM:603606 ribosomal protein S6 kinase A4 GO:0000287,GO:0001818,GO:0004674,GO:0004711,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006468,GO:0006954,GO:0016572,GO:0032793,GO:0033129,GO:0035066,GO:0035556,GO:0043987,GO:0043988,GO:0045944,GO:0051092,GO:0070498 magnesium ion binding|negative regulation of cytokine production|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|protein phosphorylation|inflammatory response|histone phosphorylation|positive regulation of CREB transcription factor activity|positive regulation of histone phosphorylation|positive regulation of histone acetylation|intracellular signal transduction|histone H3-S10 phosphorylation|histone H3-S28 phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of NF-kappaB transcription factor activity|interleukin-1-mediated signaling pathway hsa04010,hsa04668 MAPK signaling pathway|TNF signaling pathway RPS6KA5 218.058866683053 242.715546134422 193.402187231684 0.796826533412791 -0.327662406585647 0.20173301527038 1 0.94147 1.01712 0.991483 0.676595 GeneID:9252,Genbank:NM_001322232.1,HGNC:HGNC:10434,MIM:603607 ribosomal protein S6 kinase A5 GO:0000287,GO:0001818,GO:0002223,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006468,GO:0006954,GO:0007173,GO:0007411,GO:0016572,GO:0032793,GO:0033129,GO:0035066,GO:0035556,GO:0043987,GO:0043988,GO:0043990,GO:0045892,GO:0045944,GO:0051092,GO:0070498 magnesium ion binding|negative regulation of cytokine production|stimulatory C-type lectin receptor signaling pathway|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|protein phosphorylation|inflammatory response|epidermal growth factor receptor signaling pathway|axon guidance|histone phosphorylation|positive regulation of CREB transcription factor activity|positive regulation of histone phosphorylation|positive regulation of histone acetylation|intracellular signal transduction|histone H3-S10 phosphorylation|histone H3-S28 phosphorylation|histone H2A-S1 phosphorylation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of NF-kappaB transcription factor activity|interleukin-1-mediated signaling pathway hsa04010,hsa04261,hsa04668,hsa04713,hsa04722,hsa05200,hsa05206,hsa05219 MAPK signaling pathway|Adrenergic signaling in cardiomyocytes|TNF signaling pathway|Circadian entrainment|Neurotrophin signaling pathway|Pathways in cancer|MicroRNAs in cancer|Bladder cancer RPS6KB1 507.015274770795 556.008131803248 458.022417738342 0.823769278792527 -0.27968777076921 0.245810991908313 1 3.55631 2.91508 2.98363 2.14825 GeneID:6198,Genbank:NM_001272044.1,HGNC:HGNC:10436,MIM:608938 ribosomal protein S6 kinase B1 GO:0000082,GO:0001662,GO:0003009,GO:0004672,GO:0004674,GO:0004711,GO:0004712,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005829,GO:0006915,GO:0007165,GO:0007281,GO:0007568,GO:0007584,GO:0007616,GO:0009408,GO:0009611,GO:0009612,GO:0009749,GO:0009986,GO:0014732,GO:0014878,GO:0014911,GO:0016301,GO:0016477,GO:0030054,GO:0030165,GO:0031929,GO:0032496,GO:0032869,GO:0033574,GO:0033762,GO:0034612,GO:0042277,GO:0042802,GO:0043005,GO:0043066,GO:0043201,GO:0043491,GO:0045202,GO:0045471,GO:0045727,GO:0045931,GO:0045948,GO:0046324,GO:0046627,GO:0048015,GO:0048471,GO:0048633,GO:0048661,GO:0051721,GO:0071363,GO:0071549,GO:2001237 G1/S transition of mitotic cell cycle|behavioral fear response|skeletal muscle contraction|protein kinase activity|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|protein serine/threonine/tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial outer membrane|cytosol|apoptotic process|signal transduction|germ cell development|aging|response to nutrient|long-term memory|response to heat|response to wounding|response to mechanical stimulus|response to glucose|cell surface|skeletal muscle atrophy|response to electrical stimulus involved in regulation of muscle adaptation|positive regulation of smooth muscle cell migration|kinase activity|cell migration|cell junction|PDZ domain binding|TOR signaling|response to lipopolysaccharide|cellular response to insulin stimulus|response to testosterone|response to glucagon|response to tumor necrosis factor|peptide binding|identical protein binding|neuron projection|negative regulation of apoptotic process|response to leucine|protein kinase B signaling|synapse|response to ethanol|positive regulation of translation|positive regulation of mitotic cell cycle|positive regulation of translational initiation|regulation of glucose import|negative regulation of insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|perinuclear region of cytoplasm|positive regulation of skeletal muscle tissue growth|positive regulation of smooth muscle cell proliferation|protein phosphatase 2A binding|cellular response to growth factor stimulus|cellular response to dexamethasone stimulus|negative regulation of extrinsic apoptotic signaling pathway hsa01521,hsa01522,hsa04012,hsa04066,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04350,hsa04371,hsa04666,hsa04714,hsa04910,hsa04931,hsa05163,hsa05165,hsa05170,hsa05200,hsa05205,hsa05210,hsa05212,hsa05221,hsa05224,hsa05225,hsa05226,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|TGF-beta signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Thermogenesis|Insulin signaling pathway|Insulin resistance|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Pancreatic cancer|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer RPS6KB2 1291.62932160771 1307.30481295895 1275.95383025646 0.976018612957196 -0.0350194342252299 0.798295295313725 1 23.327 24.5334 23.2048 25.8478 GeneID:6199,Genbank:NM_003952.2,HGNC:HGNC:10437,MIM:608939 ribosomal protein S6 kinase B2 GO:0004672,GO:0004674,GO:0004711,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006412,GO:0007165,GO:0035556,GO:0042277,GO:0043491,GO:0045948 protein kinase activity|protein serine/threonine kinase activity|ribosomal protein S6 kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|translation|signal transduction|intracellular signal transduction|peptide binding|protein kinase B signaling|positive regulation of translational initiation hsa01521,hsa01522,hsa04012,hsa04066,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04350,hsa04371,hsa04666,hsa04714,hsa04910,hsa04931,hsa05163,hsa05165,hsa05170,hsa05200,hsa05205,hsa05210,hsa05212,hsa05221,hsa05224,hsa05225,hsa05226,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|HIF-1 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|TGF-beta signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Thermogenesis|Insulin signaling pathway|Insulin resistance|Human cytomegalovirus infection|Human papillomavirus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Pancreatic cancer|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer RPS6KC1 441.82009708265 419.329287934393 464.310906230907 1.10727039486818 0.147007570539283 0.39651561159475 1 2.39675 1.99335 2.73866 2.1347 GeneID:26750,Genbank:NM_001349651.1,HGNC:HGNC:10439,MIM:617517 ribosomal protein S6 kinase C1 GO:0004674,GO:0005524,GO:0005769,GO:0007165,GO:0016020,GO:0035091 protein serine/threonine kinase activity|ATP binding|early endosome|signal transduction|membrane|phosphatidylinositol binding RPS6KL1 51.8616253069189 52.350379114321 51.3728714995168 0.981327592438832 -0.0271932692558373 0.944346113548995 1 0.252932 0.34397 0.298934 0.234001 GeneID:83694,Genbank:XM_017021682.1,HGNC:HGNC:20222 ribosomal protein S6 kinase like 1 GO:0004674,GO:0005524,GO:0005737,GO:0005840,GO:0007165 protein serine/threonine kinase activity|ATP binding|cytoplasm|ribosome|signal transduction RPS7 9131.37876203132 9936.85881451836 8325.89870954429 0.837880346793259 -0.255183859808911 0.204928939654936 1 633.452 703.427 504.994 625.148 GeneID:6201,Genbank:NM_001011.3,HGNC:HGNC:10440,MIM:603658 ribosomal protein S7 GO:0001843,GO:0002181,GO:0003723,GO:0003730,GO:0003735,GO:0005634,GO:0005730,GO:0005815,GO:0005840,GO:0005925,GO:0006364,GO:0008266,GO:0010628,GO:0016020,GO:0019901,GO:0022627,GO:0030154,GO:0030529,GO:0030686,GO:0031012,GO:0032040,GO:0042274,GO:0043234,GO:0048027,GO:0050821,GO:0070062,GO:1902255,GO:1904667,GO:1990948,GO:2000059 neural tube closure|cytoplasmic translation|RNA binding|mRNA 3'-UTR binding|structural constituent of ribosome|nucleus|nucleolus|microtubule organizing center|ribosome|focal adhesion|rRNA processing|poly(U) RNA binding|positive regulation of gene expression|membrane|protein kinase binding|cytosolic small ribosomal subunit|cell differentiation|intracellular ribonucleoprotein complex|90S preribosome|extracellular matrix|small-subunit processome|ribosomal small subunit biogenesis|protein complex|mRNA 5'-UTR binding|protein stabilization|extracellular exosome|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of ubiquitin protein ligase activity|ubiquitin ligase inhibitor activity|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process hsa03010 Ribosome RPS8 16098.5048438249 17537.6964867938 14659.313200856 0.83587449537029 -0.258641753657102 0.161041825903035 1 986.978 1051.5 771.675 938.607 GeneID:6202,Genbank:NM_001012.1,HGNC:HGNC:10441,MIM:600357 ribosomal protein S8 GO:0000184,GO:0000462,GO:0003723,GO:0003735,GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0016020,GO:0019083,GO:0022627,GO:0030529,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|structural constituent of ribosome|nucleus|nucleoplasm|endoplasmic reticulum|cytosol|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|membrane|viral transcription|cytosolic small ribosomal subunit|intracellular ribonucleoprotein complex|extracellular exosome hsa03010 Ribosome RPS9 11172.3642623178 11560.1744548464 10784.5540697892 0.932905823516177 -0.100196645968803 0.660652897476142 1 428.555 480.584 383.516 489.492 GeneID:6203,Genbank:XM_017027112.1,HGNC:HGNC:10442,MIM:603631 ribosomal protein S9 GO:0000184,GO:0003723,GO:0003735,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005840,GO:0005925,GO:0006364,GO:0006412,GO:0006413,GO:0006614,GO:0008284,GO:0016020,GO:0019083,GO:0019843,GO:0022627,GO:0030529,GO:0045182,GO:0045903,GO:0070062 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|structural constituent of ribosome|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|ribosome|focal adhesion|rRNA processing|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|positive regulation of cell proliferation|membrane|viral transcription|rRNA binding|cytosolic small ribosomal subunit|intracellular ribonucleoprotein complex|translation regulator activity|positive regulation of translational fidelity|extracellular exosome hsa03010 Ribosome RPSA 38114.1131680699 40292.6215674123 35935.6047687274 0.891865641172159 -0.165101709197748 0.282463189233684 1 1099.51 1213.8 969.523 1110.08 GeneID:3921,Genbank:NM_001304288.1,HGNC:HGNC:6502,MIM:150370 ribosomal protein SA GO:0000028,GO:0000184,GO:0000447,GO:0000461,GO:0001618,GO:0003723,GO:0003735,GO:0005055,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006364,GO:0006407,GO:0006412,GO:0006413,GO:0006614,GO:0007155,GO:0016020,GO:0019083,GO:0022627,GO:0030686,GO:0043022,GO:0070062 ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|virus receptor activity|RNA binding|structural constituent of ribosome|laminin receptor activity|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|rRNA processing|rRNA export from nucleus|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|cell adhesion|membrane|viral transcription|cytosolic small ribosomal subunit|90S preribosome|ribosome binding|extracellular exosome hsa03010 Ribosome RPSAP58 354.626594477516 374.417240744549 334.835948210482 0.894285603794961 -0.161192443147523 0.440342850809033 1 9.33844 9.84022 7.31431 9.47637 GeneID:388524,Genbank:NM_001355287.1,HGNC:HGNC:36809 ribosomal protein SA pseudogene 58 GO:0000028,GO:0000184,GO:0000447,GO:0000461,GO:0001618,GO:0003723,GO:0003735,GO:0005055,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006364,GO:0006407,GO:0006412,GO:0006413,GO:0006614,GO:0007155,GO:0016020,GO:0019083,GO:0022627,GO:0030686,GO:0043022,GO:0070062 ribosomal small subunit assembly|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|virus receptor activity|RNA binding|structural constituent of ribosome|laminin receptor activity|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|rRNA processing|rRNA export from nucleus|translation|translational initiation|SRP-dependent cotranslational protein targeting to membrane|cell adhesion|membrane|viral transcription|cytosolic small ribosomal subunit|90S preribosome|ribosome binding|extracellular exosome RPTOR 1373.22776036695 1333.28738891694 1413.16813181695 1.05991262166283 0.0839453350811831 0.577355688165424 1 7.90697 8.06778 8.87756 8.59339 GeneID:57521,Genbank:NM_020761.2,HGNC:HGNC:30287,MIM:607130 regulatory associated protein of MTOR complex 1 GO:0001030,GO:0001031,GO:0001032,GO:0001156,GO:0001558,GO:0001938,GO:0005654,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0007050,GO:0008361,GO:0009267,GO:0010494,GO:0010506,GO:0010800,GO:0016241,GO:0019901,GO:0030291,GO:0030295,GO:0030307,GO:0030425,GO:0030674,GO:0031669,GO:0031929,GO:0031931,GO:0032008,GO:0032403,GO:0033138,GO:0038202,GO:0043025,GO:0045945,GO:0071230,GO:0071233,GO:0071889,GO:0071902,GO:1900034,GO:1900087 RNA polymerase III type 1 promoter DNA binding|RNA polymerase III type 2 promoter DNA binding|RNA polymerase III type 3 promoter DNA binding|TFIIIC-class transcription factor binding|regulation of cell growth|positive regulation of endothelial cell proliferation|nucleoplasm|cytoplasm|lysosome|lysosomal membrane|cytosol|cell cycle arrest|regulation of cell size|cellular response to starvation|cytoplasmic stress granule|regulation of autophagy|positive regulation of peptidyl-threonine phosphorylation|regulation of macroautophagy|protein kinase binding|protein serine/threonine kinase inhibitor activity|protein kinase activator activity|positive regulation of cell growth|dendrite|protein binding, bridging|cellular response to nutrient levels|TOR signaling|TORC1 complex|positive regulation of TOR signaling|protein complex binding|positive regulation of peptidyl-serine phosphorylation|TORC1 signaling|neuronal cell body|positive regulation of transcription from RNA polymerase III promoter|cellular response to amino acid stimulus|cellular response to leucine|14-3-3 protein binding|positive regulation of protein serine/threonine kinase activity|regulation of cellular response to heat|positive regulation of G1/S transition of mitotic cell cycle hsa04136,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04213,hsa04714,hsa04910,hsa05206 Autophagy - other|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Thermogenesis|Insulin signaling pathway|MicroRNAs in cancer RPUSD1 657.946400293979 607.390210770472 708.502589817487 1.16647021511716 0.222149469729848 0.191504764499098 1 10.3129 11.6676 13.2074 13.4026 GeneID:113000,Genbank:NM_001324412.1,HGNC:HGNC:14173 RNA pseudouridylate synthase domain containing 1 GO:0000455,GO:0003723,GO:0009982,GO:0031119 enzyme-directed rRNA pseudouridine synthesis|RNA binding|pseudouridine synthase activity|tRNA pseudouridine synthesis RPUSD2 473.878369135696 477.677210732643 470.07952753875 0.98409452445462 -0.0231311986191942 0.868111061609548 1 8.53254 9.9581 9.137 9.23662 GeneID:27079,Genbank:NM_152260.2,HGNC:HGNC:24180 RNA pseudouridylate synthase domain containing 2 GO:0000455,GO:0003723,GO:0009982 enzyme-directed rRNA pseudouridine synthesis|RNA binding|pseudouridine synthase activity RPUSD3 1220.67170982065 1101.90131995733 1339.44209968396 1.21557355039363 0.281637188782414 0.0607633583496628 0.88260138524454 13.7438 14.2752 17.4574 16.2285 GeneID:285367,Genbank:XM_024453472.1,HGNC:HGNC:28437,MIM:617759 RNA pseudouridylate synthase domain containing 3 GO:0003723,GO:0005739,GO:0005759,GO:0006397,GO:0009982,GO:0031119 RNA binding|mitochondrion|mitochondrial matrix|mRNA processing|pseudouridine synthase activity|tRNA pseudouridine synthesis RPUSD4 501.769020571225 488.371520680588 515.166520461861 1.05486601623275 0.0770597667126444 0.675225665153223 1 6.84725 7.49033 7.86482 7.38454 GeneID:84881,Genbank:NM_001144827.1,HGNC:HGNC:25898,MIM:617488 RNA pseudouridylate synthase domain containing 4 GO:0003723,GO:0005739,GO:0005759,GO:0009982,GO:0031119 RNA binding|mitochondrion|mitochondrial matrix|pseudouridine synthase activity|tRNA pseudouridine synthesis RRAD 5.24743458741559 7.10113100082778 3.3937381740034 0.477915162191458 -1.0651735560717 0.439862358355278 1 0.094285 0.198605 0.173631 0.0807378 GeneID:6236,Genbank:NM_004165.2,HGNC:HGNC:10446,MIM:179503 RRAD, Ras related glycolysis inhibitor and calcium channel regulator GO:0003924,GO:0005516,GO:0005525,GO:0005622,GO:0005886,GO:0007264,GO:1901842 GTPase activity|calmodulin binding|GTP binding|intracellular|plasma membrane|small GTPase mediated signal transduction|negative regulation of high voltage-gated calcium channel activity RRAGA 3129.52619873665 2950.52294831678 3308.52944915652 1.12133662645938 0.165219441765161 0.231034750465455 1 95.2668 99.6696 112.757 108.959 GeneID:10670,Genbank:NM_006570.4,HGNC:HGNC:16963,MIM:612194 Ras related GTP binding A GO:0003924,GO:0005525,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0006915,GO:0007050,GO:0008219,GO:0010507,GO:0016241,GO:0016567,GO:0019048,GO:0031625,GO:0032008,GO:0034198,GO:0034448,GO:0034613,GO:0042803,GO:0045919,GO:0046982,GO:0051219,GO:0071230,GO:1904263,GO:1990131 GTPase activity|GTP binding|nucleus|cytoplasm|lysosome|lysosomal membrane|cytosol|apoptotic process|cell cycle arrest|cell death|negative regulation of autophagy|regulation of macroautophagy|protein ubiquitination|modulation by virus of host morphology or physiology|ubiquitin protein ligase binding|positive regulation of TOR signaling|cellular response to amino acid starvation|EGO complex|cellular protein localization|protein homodimerization activity|positive regulation of cytolysis|protein heterodimerization activity|phosphoprotein binding|cellular response to amino acid stimulus|positive regulation of TORC1 signaling|Gtr1-Gtr2 GTPase complex hsa04140,hsa04150 Autophagy - animal|mTOR signaling pathway RRAGB 150.35584409907 148.046538663244 152.665149534896 1.0311970202975 0.0443200000687635 0.848624694498122 1 2.0864 1.68359 2.26133 1.82441 GeneID:10325,Genbank:NM_016656.3,HGNC:HGNC:19901,MIM:300725 Ras related GTP binding B GO:0003924,GO:0005525,GO:0005634,GO:0005737,GO:0005764,GO:0005765,GO:0005829,GO:0007050,GO:0010506,GO:0016241,GO:0032006,GO:0032008,GO:0032561,GO:0034198,GO:0034448,GO:0034613,GO:0046982,GO:0051020,GO:0071230,GO:1904263,GO:1990131,GO:1990253 GTPase activity|GTP binding|nucleus|cytoplasm|lysosome|lysosomal membrane|cytosol|cell cycle arrest|regulation of autophagy|regulation of macroautophagy|regulation of TOR signaling|positive regulation of TOR signaling|guanyl ribonucleotide binding|cellular response to amino acid starvation|EGO complex|cellular protein localization|protein heterodimerization activity|GTPase binding|cellular response to amino acid stimulus|positive regulation of TORC1 signaling|Gtr1-Gtr2 GTPase complex|cellular response to leucine starvation hsa04140,hsa04150 Autophagy - animal|mTOR signaling pathway RRAGC 1088.46125275844 1036.55812736273 1140.36437815415 1.10014513229039 0.137693858135466 0.355205397117727 1 16.1373 15.7025 18.4471 16.7414 GeneID:64121,Genbank:NM_001271851.1,HGNC:HGNC:19902,MIM:608267 Ras related GTP binding C GO:0000287,GO:0003924,GO:0005525,GO:0005634,GO:0005737,GO:0005764,GO:0005829,GO:0006351,GO:0006915,GO:0007050,GO:0007264,GO:0008380,GO:0010506,GO:0016049,GO:0016241,GO:0019003,GO:0032006,GO:0032008,GO:0034198,GO:0034448,GO:0034613,GO:0043200,GO:0043231,GO:0046982,GO:0051020,GO:0071230,GO:1903432,GO:1990131 magnesium ion binding|GTPase activity|GTP binding|nucleus|cytoplasm|lysosome|cytosol|transcription, DNA-templated|apoptotic process|cell cycle arrest|small GTPase mediated signal transduction|RNA splicing|regulation of autophagy|cell growth|regulation of macroautophagy|GDP binding|regulation of TOR signaling|positive regulation of TOR signaling|cellular response to amino acid starvation|EGO complex|cellular protein localization|response to amino acid|intracellular membrane-bounded organelle|protein heterodimerization activity|GTPase binding|cellular response to amino acid stimulus|regulation of TORC1 signaling|Gtr1-Gtr2 GTPase complex hsa04140,hsa04150 Autophagy - animal|mTOR signaling pathway RRAGD 1230.8780490885 1131.44764889712 1330.30844927988 1.17575784489596 0.233590958183341 0.112437454756976 1 7.45417 7.22328 9.03328 8.26328 GeneID:58528,Genbank:XM_005248755.5,HGNC:HGNC:19903,MIM:608268 Ras related GTP binding D GO:0003924,GO:0005525,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005813,GO:0005829,GO:0007050,GO:0010506,GO:0016241,GO:0019003,GO:0032008,GO:0034448,GO:0034613,GO:0046982,GO:0051020,GO:0071230,GO:0071233,GO:1904263,GO:1990131,GO:1990253 GTPase activity|GTP binding|nucleus|nucleoplasm|cytoplasm|lysosome|centrosome|cytosol|cell cycle arrest|regulation of autophagy|regulation of macroautophagy|GDP binding|positive regulation of TOR signaling|EGO complex|cellular protein localization|protein heterodimerization activity|GTPase binding|cellular response to amino acid stimulus|cellular response to leucine|positive regulation of TORC1 signaling|Gtr1-Gtr2 GTPase complex|cellular response to leucine starvation hsa04140,hsa04150 Autophagy - animal|mTOR signaling pathway RRAS 633.51885019353 564.331570983125 702.706129403936 1.24520081018992 0.316378420609576 0.0602320035179933 0.879410748501007 22.2109 25.4623 31.3568 29.2506 GeneID:6237,Genbank:NM_006270.4,HGNC:HGNC:10447,MIM:165090 RAS related GO:0002521,GO:0003924,GO:0005525,GO:0005622,GO:0005886,GO:0005925,GO:0007265,GO:0019003,GO:0030336,GO:0032403,GO:0045766,GO:0051896,GO:0060325,GO:0070062,GO:0070372 leukocyte differentiation|GTPase activity|GTP binding|intracellular|plasma membrane|focal adhesion|Ras protein signal transduction|GDP binding|negative regulation of cell migration|protein complex binding|positive regulation of angiogenesis|regulation of protein kinase B signaling|face morphogenesis|extracellular exosome|regulation of ERK1 and ERK2 cascade hsa04010,hsa04014,hsa04015,hsa04024,hsa04072,hsa04137,hsa04140,hsa04218,hsa04360,hsa04371,hsa04625,hsa04810,hsa05166,hsa05205 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Cellular senescence|Axon guidance|Apelin signaling pathway|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Human T-cell leukemia virus 1 infection|Proteoglycans in cancer RRAS2 814.242352398996 956.225652062159 672.259052735833 0.703033903436982 -0.508333830709042 0.00754188339144713 0.341216961574625 15.6453 14.4425 12.4733 9.0794 GeneID:22800,Genbank:NM_001177314.1,HGNC:HGNC:17271,MIM:600098 RAS related 2 GO:0001649,GO:0003924,GO:0005525,GO:0005783,GO:0005886,GO:0005925,GO:0007265,GO:0016020,GO:0030335,GO:0070062,GO:1901214 osteoblast differentiation|GTPase activity|GTP binding|endoplasmic reticulum|plasma membrane|focal adhesion|Ras protein signal transduction|membrane|positive regulation of cell migration|extracellular exosome|regulation of neuron death hsa04010,hsa04014,hsa04024,hsa04072,hsa04137,hsa04140,hsa04218,hsa04371,hsa04625,hsa04810,hsa05166,hsa05205 MAPK signaling pathway|Ras signaling pathway|cAMP signaling pathway|Phospholipase D signaling pathway|Mitophagy - animal|Autophagy - animal|Cellular senescence|Apelin signaling pathway|C-type lectin receptor signaling pathway|Regulation of actin cytoskeleton|Human T-cell leukemia virus 1 infection|Proteoglycans in cancer RRBP1 2159.12473917428 1945.36557429718 2372.88390405138 1.21976246285157 0.286600223991383 0.0412530535119933 0.759435523043776 12.3556 12.5678 16.957 14.1786 GeneID:6238,Genbank:NM_004587.2,HGNC:HGNC:10448,MIM:601418 ribosome binding protein 1 GO:0001649,GO:0003723,GO:0004872,GO:0005783,GO:0005840,GO:0006412,GO:0015031,GO:0016020,GO:0030176 osteoblast differentiation|RNA binding|receptor activity|endoplasmic reticulum|ribosome|translation|protein transport|membrane|integral component of endoplasmic reticulum membrane hsa04141 Protein processing in endoplasmic reticulum RREB1 475.281098227796 497.403511323922 453.158685131669 0.911048424096389 -0.134400356615191 0.452159746278731 1 2.19759 2.10439 2.2012 1.81645 GeneID:6239,Genbank:NM_001168344.1,HGNC:HGNC:10449,MIM:602209 ras responsive element binding protein 1 GO:0000122,GO:0000977,GO:0000979,GO:0001228,GO:0001650,GO:0005634,GO:0005737,GO:0006355,GO:0006366,GO:0007265,GO:0007275,GO:0010634,GO:0016604,GO:0016607,GO:0033601,GO:0045893,GO:0045944,GO:0046872,GO:0070062,GO:1900026,GO:1903691,GO:2000394 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|fibrillar center|nucleus|cytoplasm|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|Ras protein signal transduction|multicellular organism development|positive regulation of epithelial cell migration|nuclear body|nuclear speck|positive regulation of mammary gland epithelial cell proliferation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|extracellular exosome|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of wound healing, spreading of epidermal cells|positive regulation of lamellipodium morphogenesis RRH 1.73632650848144 2.98845468642911 0.484198330533773 0.162022978876865 -2.62572965732849 0.399553430975844 1 0 0.124796 0 0.0292474 GeneID:10692,Genbank:NM_006583.2,HGNC:HGNC:10450,MIM:605224 retinal pigment epithelium-derived rhodopsin homolog GO:0001750,GO:0004930,GO:0005887,GO:0007186,GO:0007601,GO:0007602,GO:0008020,GO:0018298 photoreceptor outer segment|G-protein coupled receptor activity|integral component of plasma membrane|G-protein coupled receptor signaling pathway|visual perception|phototransduction|G-protein coupled photoreceptor activity|protein-chromophore linkage RRM1 3124.00759660666 3085.88241445636 3162.13277875696 1.02470941988697 0.0352148580995036 0.785592036918014 1 29.3972 28.3909 29.6332 29.6632 GeneID:6240,Genbank:NM_001033.4,HGNC:HGNC:10451,MIM:180410 ribonucleotide reductase catalytic subunit M1 hsa00230,hsa00240,hsa00480,hsa00983 Purine metabolism|Pyrimidine metabolism|Glutathione metabolism|Drug metabolism - other enzymes RRM2 7345.41802568299 7414.60276487821 7276.23328648777 0.981338247944195 -0.0271776041900578 0.841464104207861 1 99.9259 100.563 102.217 96.8509 GeneID:6241,Genbank:NM_001165931.1,HGNC:HGNC:10452,MIM:180390 ribonucleotide reductase regulatory subunit M2 hsa00230,hsa00240,hsa00480,hsa00983,hsa04115 Purine metabolism|Pyrimidine metabolism|Glutathione metabolism|Drug metabolism - other enzymes|p53 signaling pathway RRM2B 344.424520629392 378.644569917679 310.204471341105 0.819249755538674 -0.287624757614531 0.234364264611687 1 3.86172 3.4699 3.46618 2.4346 GeneID:50484,Genbank:NM_001172478.1,HGNC:HGNC:17296,MIM:604712 ribonucleotide reductase regulatory TP53 inducible subunit M2B GO:0001822,GO:0003014,GO:0004748,GO:0005654,GO:0005739,GO:0005829,GO:0006264,GO:0006281,GO:0006979,GO:0009200,GO:0009263,GO:0046872,GO:1902254 kidney development|renal system process|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|nucleoplasm|mitochondrion|cytosol|mitochondrial DNA replication|DNA repair|response to oxidative stress|deoxyribonucleoside triphosphate metabolic process|deoxyribonucleotide biosynthetic process|metal ion binding|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator hsa00230,hsa00240,hsa00480,hsa00983,hsa04115 Purine metabolism|Pyrimidine metabolism|Glutathione metabolism|Drug metabolism - other enzymes|p53 signaling pathway RRN3 833.094454244148 886.377798302282 779.811110186015 0.879772836909521 -0.184797036331858 0.249076388835995 1 9.4862 8.7644 8.76952 7.38404 GeneID:54700,Genbank:NM_001301064.1,HGNC:HGNC:30346,MIM:605121 RRN3 homolog, RNA polymerase I transcription factor GO:0001042,GO:0001164,GO:0001180,GO:0001181,GO:0001701,GO:0005634,GO:0005654,GO:0005730,GO:0006361,GO:0007000,GO:0007028,GO:0008283,GO:0010976,GO:0042254,GO:0045893,GO:0048872,GO:1902254,GO:2000142 RNA polymerase I core binding|RNA polymerase I CORE element sequence-specific DNA binding|transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript|transcription factor activity, core RNA polymerase I binding|in utero embryonic development|nucleus|nucleoplasm|nucleolus|transcription initiation from RNA polymerase I promoter|nucleolus organization|cytoplasm organization|cell proliferation|positive regulation of neuron projection development|ribosome biogenesis|positive regulation of transcription, DNA-templated|homeostasis of number of cells|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|regulation of DNA-templated transcription, initiation RRNAD1 573.572842814914 503.073662739309 644.07202289052 1.28027378611604 0.356452363064838 0.0376715528233496 0.744558420459959 5.65884 6.21821 8.20873 7.42923 GeneID:51093,Genbank:NM_015997.3,HGNC:HGNC:24273 ribosomal RNA adenine dimethylase domain containing 1 GO:0000179,GO:0016021 rRNA (adenine-N6,N6-)-dimethyltransferase activity|integral component of membrane RRP1 917.128847171894 961.97427271841 872.283421625378 0.906763773588687 -0.14120134023118 0.347717472856078 1 16.3111 17.222 15.01 15.8009 GeneID:8568,Genbank:NM_003683.5,HGNC:HGNC:18785,MIM:610653 ribosomal RNA processing 1 GO:0003723,GO:0005634,GO:0005730,GO:0006364,GO:0030687,GO:0030688 RNA binding|nucleus|nucleolus|rRNA processing|preribosome, large subunit precursor|preribosome, small subunit precursor RRP12 1700.38747268709 1773.39279783314 1627.38214754105 0.917665928005065 -0.123959052063227 0.374779847634177 1 13.2256 13.7289 12.5225 11.8073 GeneID:23223,Genbank:NM_001284337.1,HGNC:HGNC:29100,MIM:617723 ribosomal RNA processing 12 homolog GO:0003723,GO:0005730,GO:0016021,GO:0031965 RNA binding|nucleolus|integral component of membrane|nuclear membrane RRP15 290.878414231353 326.352025733151 255.404802729555 0.782605231745652 -0.353643340145361 0.0864321569310189 0.964561165794104 1.59731 1.3927 1.18642 1.13427 GeneID:51018,Genbank:NM_016052.3,HGNC:HGNC:24255,MIM:611193 ribosomal RNA processing 15 homolog GO:0000460,GO:0000470,GO:0030687 maturation of 5.8S rRNA|maturation of LSU-rRNA|preribosome, large subunit precursor RRP1B 1333.88125135986 1439.69645872317 1228.06604399655 0.853003448439189 -0.229376520945134 0.122041474373597 1 11.0588 10.3554 9.48731 8.84932 GeneID:23076,Genbank:NM_015056.2,HGNC:HGNC:23818,MIM:610654 ribosomal RNA processing 1B GO:0000791,GO:0000792,GO:0001105,GO:0001652,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0006397,GO:0006915,GO:0008380,GO:0010923,GO:0030687,GO:0030688,GO:0034260,GO:0043065,GO:0043484,GO:0043923,GO:0045944,GO:0098586 euchromatin|heterochromatin|RNA polymerase II transcription coactivator activity|granular component|RNA binding|nucleus|nucleoplasm|nucleolus|cytosol|rRNA processing|mRNA processing|apoptotic process|RNA splicing|negative regulation of phosphatase activity|preribosome, large subunit precursor|preribosome, small subunit precursor|negative regulation of GTPase activity|positive regulation of apoptotic process|regulation of RNA splicing|positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter|cellular response to virus RRP36 2300.75714643922 2314.15291524763 2287.3613776308 0.988422745342238 -0.0167998848935843 0.889519342357988 1 67.775 72.1637 68.2912 71.651 GeneID:88745,Genbank:NM_033112.3,HGNC:HGNC:21374,MIM:613475 ribosomal RNA processing 36 GO:0000462,GO:0000469,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0030686,GO:0042274 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cleavage involved in rRNA processing|RNA binding|nucleus|nucleoplasm|nucleolus|rRNA processing|90S preribosome|ribosomal small subunit biogenesis RRP7A 1137.09904924488 1176.08338109567 1098.11471739408 0.933704816380486 -0.0989615698486881 0.496181129626767 1 7.24225 7.59743 6.82822 7.39976 GeneID:27341,Genbank:NM_015703.4,HGNC:HGNC:24286 ribosomal RNA processing 7 homolog A GO:0000028,GO:0001825,GO:0003723,GO:0005654,GO:0005737,GO:0006364,GO:0032545,GO:0034456 ribosomal small subunit assembly|blastocyst formation|RNA binding|nucleoplasm|cytoplasm|rRNA processing|CURI complex|UTP-C complex hsa03008 Ribosome biogenesis in eukaryotes RRP8 301.743731015782 306.404194077809 297.083267953756 0.969579639234032 -0.0445686917494702 0.834283131453795 1 1.06124 1.08874 1.06835 0.952138 GeneID:23378,Genbank:XM_011519955.2,HGNC:HGNC:29030,MIM:615818 ribosomal RNA processing 8 GO:0000183,GO:0003723,GO:0005634,GO:0005654,GO:0005677,GO:0005730,GO:0005829,GO:0005886,GO:0006351,GO:0006364,GO:0008757,GO:0016569,GO:0033553,GO:0035064,GO:0042149,GO:0046015,GO:0071158,GO:0072332 chromatin silencing at rDNA|RNA binding|nucleus|nucleoplasm|chromatin silencing complex|nucleolus|cytosol|plasma membrane|transcription, DNA-templated|rRNA processing|S-adenosylmethionine-dependent methyltransferase activity|covalent chromatin modification|rDNA heterochromatin|methylated histone binding|cellular response to glucose starvation|regulation of transcription by glucose|positive regulation of cell cycle arrest|intrinsic apoptotic signaling pathway by p53 class mediator RRP9 1119.14119702014 1217.70900729587 1020.5733867444 0.838109417463174 -0.254789490906898 0.0890043153713085 0.976365147251285 29.5893 28.2249 23.5948 24.7762 GeneID:9136,Genbank:NM_004704.4,HGNC:HGNC:16829 ribosomal RNA processing 9, U3 small nucleolar RNA binding protein GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0031428,GO:0032040 RNA binding|nucleoplasm|nucleolus|rRNA processing|box C/D snoRNP complex|small-subunit processome RRS1 1289.93034264701 1493.82482700169 1086.03585829233 0.727016875514216 -0.459939242519511 0.00186304907671659 0.153441233527396 35.059 33.5908 25.6039 25.146 GeneID:23212,Genbank:NM_015169.3,HGNC:HGNC:17083 ribosome biogenesis regulator homolog GO:0000027,GO:0000055,GO:0000447,GO:0000794,GO:0001650,GO:0002244,GO:0003723,GO:0005634,GO:0005730,GO:0005783,GO:0007080,GO:0008097,GO:0030687,GO:0042273,GO:1901796,GO:1902570 ribosomal large subunit assembly|ribosomal large subunit export from nucleus|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|condensed nuclear chromosome|fibrillar center|hematopoietic progenitor cell differentiation|RNA binding|nucleus|nucleolus|endoplasmic reticulum|mitotic metaphase plate congression|5S rRNA binding|preribosome, large subunit precursor|ribosomal large subunit biogenesis|regulation of signal transduction by p53 class mediator|protein localization to nucleolus RSAD1 1024.70567479065 1006.51090136503 1042.90044821627 1.03615415074182 0.0512386516413243 0.734400098362659 1 18.2866 17.4312 18.4547 18.6792 GeneID:55316,Genbank:NM_018346.2,HGNC:HGNC:25634 radical S-adenosyl methionine domain containing 1 GO:0004109,GO:0005739,GO:0006779,GO:0046872,GO:0051539 coproporphyrinogen oxidase activity|mitochondrion|porphyrin-containing compound biosynthetic process|metal ion binding|4 iron, 4 sulfur cluster binding RSAD2 161.979606687106 15.4705624536799 308.488650920532 19.9403642785562 4.31761986059469 0.219835300075358 1 0.15762 0.138321 6.48517 0.170066 GeneID:91543,Genbank:XM_011510415.2,HGNC:HGNC:30908,MIM:607810 radical S-adenosyl methionine domain containing 2 GO:0001650,GO:0003824,GO:0005739,GO:0005741,GO:0005743,GO:0005783,GO:0005789,GO:0005794,GO:0005811,GO:0009615,GO:0016032,GO:0034157,GO:0034165,GO:0035710,GO:0043367,GO:0043621,GO:0045071,GO:0046872,GO:0050709,GO:0051539,GO:0051607,GO:0060337,GO:2000553 fibrillar center|catalytic activity|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|lipid droplet|response to virus|viral process|positive regulation of toll-like receptor 7 signaling pathway|positive regulation of toll-like receptor 9 signaling pathway|CD4-positive, alpha-beta T cell activation|CD4-positive, alpha-beta T cell differentiation|protein self-association|negative regulation of viral genome replication|metal ion binding|negative regulation of protein secretion|4 iron, 4 sulfur cluster binding|defense response to virus|type I interferon signaling pathway|positive regulation of T-helper 2 cell cytokine production hsa05164 Influenza A RSBN1 210.804567223546 199.147217634902 222.461916812191 1.117072683486 0.159723059315697 0.533496673782435 1 0.60716 0.459377 0.723327 0.538998 GeneID:54665,Genbank:NM_018364.4,HGNC:HGNC:25642,MIM:615858 round spermatid basic protein 1 GO:0005634,GO:0016569,GO:0046872,GO:0051213 nucleus|covalent chromatin modification|metal ion binding|dioxygenase activity RSBN1L 226.353153498739 216.65551793642 236.050789061059 1.0895212423361 0.123694324874369 0.62314386321279 1 2.3285 2.46613 3.14131 2.12309 GeneID:222194,Genbank:NM_198467.2,HGNC:HGNC:24765 round spermatid basic protein 1 like GO:0005634 nucleus RSC1A1 49.0418059343889 46.2195822623 51.8640296064777 1.12212242231323 0.166230080964017 0.700950956131458 1 1.39538 1.37635 1.61185 1.19499 GeneID:6248,Genbank:NM_006511.2,HGNC:HGNC:10458,MIM:601966 regulator of solute carriers 1 GO:0005654,GO:0005794,GO:0005886,GO:0006351,GO:0006355,GO:0006810,GO:0008200,GO:0030054,GO:0051051 nucleoplasm|Golgi apparatus|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|transport|ion channel inhibitor activity|cell junction|negative regulation of transport RSF1 151.966013596339 148.834576368419 155.097450824259 1.04207943213637 0.0594652507273403 0.808228928242418 1 0.433749 0.377574 0.502645 0.354724 GeneID:51773,Genbank:XM_005274051.2,HGNC:HGNC:18118,MIM:608522 remodeling and spacing factor 1 RSL1D1 2574.25295274799 2792.65333030246 2355.85257519352 0.843589338365307 -0.245387233023536 0.0755429880297685 0.94157495521624 17.4245 17.7181 15.9062 14.1067 GeneID:26156,Genbank:NM_015659.2,HGNC:HGNC:24534,MIM:615874 ribosomal L1 domain containing 1 GO:0000470,GO:0001649,GO:0003723,GO:0003730,GO:0005730,GO:0016020,GO:0030686,GO:0032880,GO:0042981,GO:0045296,GO:0048027,GO:2000772 maturation of LSU-rRNA|osteoblast differentiation|RNA binding|mRNA 3'-UTR binding|nucleolus|membrane|90S preribosome|regulation of protein localization|regulation of apoptotic process|cadherin binding|mRNA 5'-UTR binding|regulation of cellular senescence RSL24D1 1469.84610982729 1582.30520269106 1357.38701696353 0.857854107194361 -0.221195781339639 0.128830413068371 1 44.1464 46.1531 38.7788 40.3333 GeneID:51187,Genbank:NM_016304.2,HGNC:HGNC:18479,MIM:613262 ribosomal L24 domain containing 1 GO:0000027,GO:0003723,GO:0003735,GO:0005634,GO:0005730,GO:0006412,GO:0022625,GO:1902626 ribosomal large subunit assembly|RNA binding|structural constituent of ribosome|nucleus|nucleolus|translation|cytosolic large ribosomal subunit|assembly of large subunit precursor of preribosome hsa03010 Ribosome RSPH1 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.0491881 0.0225188 0 0 GeneID:89765,Genbank:NM_001286506.1,HGNC:HGNC:12371,MIM:609314 radial spoke head 1 homolog GO:0000794,GO:0001520,GO:0005634,GO:0005829,GO:0007286,GO:0031514,GO:0035082,GO:0051321,GO:0072687 condensed nuclear chromosome|outer dense fiber|nucleus|cytosol|spermatid development|motile cilium|axoneme assembly|meiotic cell cycle|meiotic spindle RSPH10B2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:728194,Genbank:XM_024446902.1,HGNC:HGNC:34385 radial spoke head 10 homolog B2 RSPH14 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0 0 GeneID:27156,Genbank:XM_017028774.1,HGNC:HGNC:13437,MIM:605663 radial spoke head 14 homolog RSPH3 305.17411286835 315.215670657933 295.132555078766 0.936287699348042 -0.094976190456183 0.643262448182828 1 1.86243 1.86158 1.74756 1.70636 GeneID:83861,Genbank:NM_001346418.1,HGNC:HGNC:21054,MIM:615876 radial spoke head 3 homolog GO:0005737,GO:0005856,GO:0042995 cytoplasm|cytoskeleton|cell projection RSPH4A 6.0133837367925 5.72696934432558 6.29979812925943 1.10002302273565 0.13753371869445 0.972643900101221 1 0.0291205 0.016909 0.0281604 0.0313611 GeneID:345895,Genbank:XM_017010826.1,HGNC:HGNC:21558,MIM:612647 radial spoke head 4 homolog A GO:0001534,GO:0003341,GO:0005634,GO:0005654,GO:0005730,GO:0005930,GO:0031514,GO:0035082 radial spoke|cilium movement|nucleus|nucleoplasm|nucleolus|axoneme|motile cilium|axoneme assembly RSPH6A 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0161835 0 0 0.0139801 GeneID:81492,Genbank:NM_030785.3,HGNC:HGNC:14241,MIM:607548 radial spoke head 6 homolog A GO:0005622 intracellular RSPH9 0.780196841909191 1.07619535328461 0.484198330533773 0.449916763769675 -1.15226997256519 0.981239839765731 1 0.0514725 0 0 0.0448655 GeneID:221421,Genbank:NM_152732.4,HGNC:HGNC:21057,MIM:612648 radial spoke head 9 homolog GO:0003341,GO:0005930,GO:0031514,GO:0035082,GO:0044458,GO:0060294 cilium movement|axoneme|motile cilium|axoneme assembly|motile cilium assembly|cilium movement involved in cell motility RSPO3 5.93884277508 5.09281911831339 6.7848664318466 1.33224178480024 0.413855936821347 0.802134670527977 1 0.0311109 0.0373628 0.0449308 0.0487995 GeneID:84870,Genbank:XM_017011378.1,HGNC:HGNC:20866,MIM:610574 R-spondin 3 GO:0001974,GO:0002040,GO:0005102,GO:0005109,GO:0005576,GO:0008201,GO:0016055,GO:0030111,GO:0030177,GO:0060670,GO:0090263,GO:2000052,GO:2000096 blood vessel remodeling|sprouting angiogenesis|receptor binding|frizzled binding|extracellular region|heparin binding|Wnt signaling pathway|regulation of Wnt signaling pathway|positive regulation of Wnt signaling pathway|branching involved in labyrinthine layer morphogenesis|positive regulation of canonical Wnt signaling pathway|positive regulation of non-canonical Wnt signaling pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway RSPRY1 818.881824913639 822.553863189094 815.209786638184 0.991071616243541 -0.0129387825146769 0.9711515474568 1 7.04142 6.27079 7.49514 6.12388 GeneID:89970,Genbank:XM_024450483.1,HGNC:HGNC:29420,MIM:616585 ring finger and SPRY domain containing 1 GO:0005576,GO:0046872 extracellular region|metal ion binding RSRC1 266.710322227245 264.421749643746 268.998894810744 1.01731001770151 0.0247593968393586 0.896401014866928 1 1.39351 1.2589 1.54946 1.22836 GeneID:51319,Genbank:NM_001271838.1,HGNC:HGNC:24152,MIM:613352 arginine and serine rich coiled-coil 1 GO:0000380,GO:0000398,GO:0005634,GO:0005737,GO:0006468,GO:0006913,GO:0008380,GO:0016607,GO:0046677 alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|nucleus|cytoplasm|protein phosphorylation|nucleocytoplasmic transport|RNA splicing|nuclear speck|response to antibiotic RSRC2 501.51439382904 565.847777461972 437.181010196108 0.772612401443052 -0.372183259982804 0.124568131508606 1 5.35229 4.12267 4.22658 3.26946 GeneID:65117,Genbank:NM_023012.5,HGNC:HGNC:30559 arginine and serine rich coiled-coil 2 GO:0003723 RNA binding RSRP1 317.50405840294 330.686233111613 304.321883694267 0.920273822199162 -0.119864904204933 0.552192385281613 1 4.70759 4.44841 3.96259 4.57402 GeneID:57035,Genbank:NM_001321772.1,HGNC:HGNC:25234 arginine and serine rich protein 1 RSU1 1883.51852231841 1938.51336632403 1828.52367831279 0.943260804943631 -0.0842713738521762 0.55399954330551 1 19.3124 19.692 19.4742 17.9577 GeneID:6251,Genbank:NM_152724.2,HGNC:HGNC:10464,MIM:179555 Ras suppressor protein 1 GO:0005829,GO:0005925,GO:0007165,GO:0010811,GO:0043547,GO:0070062 cytosol|focal adhesion|signal transduction|positive regulation of cell-substrate adhesion|positive regulation of GTPase activity|extracellular exosome RTBDN 2.10142789617248 3.71865746181119 0.484198330533773 0.130207833204928 -2.94111185232875 0.330976860606757 1 0.0855526 0 0 0 GeneID:83546,Genbank:XM_017027344.1,HGNC:HGNC:30310,MIM:609553 retbindin GO:0005886,GO:0033165 plasma membrane|interphotoreceptor matrix RTCA 800.629607504279 804.020444811541 797.238770197017 0.991565295810216 -0.0122203160390249 0.916023040061802 1 10.5367 12.2366 12.375 10.754 GeneID:8634,Genbank:NM_001130841.1,HGNC:HGNC:17981,MIM:611286 RNA 3'-terminal phosphate cyclase GO:0003723,GO:0003963,GO:0005524,GO:0005634,GO:0005654,GO:0006396 RNA binding|RNA-3'-phosphate cyclase activity|ATP binding|nucleus|nucleoplasm|RNA processing RTCB 2796.93050574115 2941.08611316489 2652.7748983174 0.90197117535697 -0.148846765435558 0.272920108406143 1 48.3572 51.5309 45.2387 45.4523 GeneID:51493,Genbank:NM_014306.4,HGNC:HGNC:26935,MIM:613901 RNA 2',3'-cyclic phosphate and 5'-OH ligase GO:0001701,GO:0001890,GO:0003723,GO:0003972,GO:0005524,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005789,GO:0005829,GO:0006388,GO:0017166,GO:0043231,GO:0046872,GO:0072669 in utero embryonic development|placenta development|RNA binding|RNA ligase (ATP) activity|ATP binding|nucleus|nuclear envelope|nucleoplasm|cytoplasm|endoplasmic reticulum membrane|cytosol|tRNA splicing, via endonucleolytic cleavage and ligation|vinculin binding|intracellular membrane-bounded organelle|metal ion binding|tRNA-splicing ligase complex RTEL1 521.510723971494 518.649069396612 524.372378546377 1.01103503213921 0.0158329871696041 0.925654275740613 1 3.71782 3.28123 3.7096 3.68612 GeneID:51750,Genbank:NM_032957.4,HGNC:HGNC:15888,MIM:608833 regulator of telomere elongation helicase 1 GO:0000723,GO:0003677,GO:0004003,GO:0005524,GO:0005634,GO:0006260,GO:0006281,GO:0006310,GO:0010569,GO:0046872,GO:0051539 telomere maintenance|DNA binding|ATP-dependent DNA helicase activity|ATP binding|nucleus|DNA replication|DNA repair|DNA recombination|regulation of double-strand break repair via homologous recombination|metal ion binding|4 iron, 4 sulfur cluster binding RTF1 1986.86476085008 2015.76133438881 1957.96818731135 0.971329370153346 -0.041967509734425 0.761904411841957 1 12.7102 13.5435 13.7214 11.9735 GeneID:23168,Genbank:NM_015138.4,HGNC:HGNC:28996,MIM:611633 RTF1 homolog, Paf1/RNA polymerase II complex component GO:0000122,GO:0001076,GO:0001711,GO:0001832,GO:0003697,GO:0003723,GO:0005654,GO:0005730,GO:0006366,GO:0006368,GO:0016055,GO:0016567,GO:0016593,GO:0019827,GO:0032968,GO:0045944,GO:0051571,GO:0080182,GO:1990269 negative regulation of transcription from RNA polymerase II promoter|transcription factor activity, RNA polymerase II transcription factor binding|endodermal cell fate commitment|blastocyst growth|single-stranded DNA binding|RNA binding|nucleoplasm|nucleolus|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|stem cell population maintenance|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|histone H3-K4 trimethylation|RNA polymerase II C-terminal domain phosphoserine binding RTF2 3123.39857903875 3030.53682300306 3216.26033507444 1.06128403082307 0.0858108155569028 0.534257117181783 1 44.0703 45.2015 45.0813 49.9758 GeneID:51507,Genbank:NM_001283035.1,HGNC:HGNC:15890 replication termination factor 2 GO:0005634,GO:0071171,GO:1902979 nucleus|site-specific DNA replication termination at RTS1 barrier|mitotic DNA replication termination RTKN 322.295192027353 319.88606195919 324.704322095516 1.01506242599886 0.0215684554001405 0.934230755197874 1 2.66786 2.79478 3.22514 2.9243 GeneID:6242,Genbank:NM_001015055.1,HGNC:HGNC:10466,MIM:602288 rhotekin GO:0005095,GO:0005525,GO:0005829,GO:0006915,GO:0007165,GO:0007266,GO:0017049,GO:0032185,GO:0042981 GTPase inhibitor activity|GTP binding|cytosol|apoptotic process|signal transduction|Rho protein signal transduction|GTP-Rho binding|septin cytoskeleton organization|regulation of apoptotic process RTKN2 211.822769376964 222.488348485223 201.157190268705 0.904124605347883 -0.145406478077408 0.58683788591642 1 0.836805 0.977669 1.04369 0.640927 GeneID:219790,Genbank:XM_017015843.1,HGNC:HGNC:19364 rhotekin 2 GO:0007165,GO:0030097 signal transduction|hemopoiesis RTL1 3.09851417440109 4.25675513845349 1.94027321034868 0.455810387781336 -1.13349429132441 0.673032996352546 1 0.0640457 0.00801335 0.0339359 0 GeneID:388015,Genbank:NM_001134888.2,HGNC:HGNC:14665,MIM:611896 retrotransposon Gag like 1 GO:0007275,GO:0016021 multicellular organism development|integral component of membrane RTL10 434.884475118063 450.569396145825 419.199554090301 0.930377335158884 -0.104112143016213 0.557455264686378 1 2.73001 2.92166 2.69552 2.6433 GeneID:79680,Genbank:NM_024627.5,HGNC:HGNC:26112 retrotransposon Gag like 10 GO:0005739,GO:0051881,GO:0097345 mitochondrion|regulation of mitochondrial membrane potential|mitochondrial outer membrane permeabilization RTL3 270.208757733273 292.769455718119 247.648059748428 0.845880794295923 -0.241473728936353 0.232051678689228 1 3.2491 3.90983 3.04337 2.94398 GeneID:203430,Genbank:NM_152694.2,HGNC:HGNC:22997 retrotransposon Gag like 3 GO:0003676,GO:0005634,GO:0008270 nucleic acid binding|nucleus|zinc ion binding RTL5 18.9634677271308 16.1145213348001 21.8124141194615 1.35358746724649 0.436788115839231 0.55191137883275 1 0.0742267 0.172139 0.202162 0.123404 GeneID:340526,Genbank:NM_001024455.3,HGNC:HGNC:29430 retrotransposon Gag like 5 RTL6 1687.18468807178 1735.82978767095 1638.53958847261 0.943951763076448 -0.0832149566439506 0.559261922335903 1 15.0226 14.851 14.8218 13.8509 GeneID:84247,Genbank:NM_032287.2,HGNC:HGNC:13343 retrotransposon Gag like 6 RTL8A 1875.95407339363 1732.07392959041 2019.83421719684 1.16613626167474 0.221736375636736 0.12228973864259 1 62.9631 64.6527 72.8756 79.2227 GeneID:26071,Genbank:NM_001134321.1,HGNC:HGNC:24514 retrotransposon Gag like 8A RTL8B 773.950061654171 735.671214222005 812.228909086336 1.10406509509182 0.142825235157381 0.391722371969276 1 15.7006 18.658 19.3225 18.9912 GeneID:441518,Genbank:NM_001078173.1,HGNC:HGNC:33156 retrotransposon Gag like 8B RTL8C 4183.70926495588 3834.82885915506 4532.58967075669 1.18195357269617 0.24117336736275 0.0771556928888518 0.94157495521624 154.984 167.01 192.653 198.892 GeneID:8933,Genbank:NM_001078171.1,HGNC:HGNC:2569,MIM:300213 retrotransposon Gag like 8C GO:0005886 plasma membrane RTL9 23.2847576285564 23.3018962298898 23.267619027223 0.998528995137194 -0.00212377384476443 1 1 0.121582 0.0865741 0.149953 0.0838689 GeneID:57529,Genbank:XM_017029695.1,HGNC:HGNC:29245,MIM:300965 retrotransposon Gag like 9 RTN1 270.867376793662 239.294854975829 302.439898611496 1.26387965442068 0.337859097821749 0.106872053675033 1 1.29461 1.61908 2.18174 1.60082 GeneID:6252,Genbank:NM_021136.2,HGNC:HGNC:10467,MIM:600865 reticulon 1 GO:0005783,GO:0005789,GO:0030176,GO:0030182 endoplasmic reticulum|endoplasmic reticulum membrane|integral component of endoplasmic reticulum membrane|neuron differentiation RTN2 154.640509239966 141.118912451795 168.162106028137 1.19163408437958 0.252941294781088 0.32495449666916 1 2.06514 2.11788 2.46312 2.64663 GeneID:6253,Genbank:NM_206900.2,HGNC:HGNC:10468,MIM:603183 reticulon 2 GO:0005783,GO:0014802,GO:0030176,GO:0030315,GO:0046324,GO:0065002 endoplasmic reticulum|terminal cisterna|integral component of endoplasmic reticulum membrane|T-tubule|regulation of glucose import|intracellular protein transmembrane transport RTN3 5453.39220842091 5080.01499757585 5826.76941926596 1.14699846792706 0.197863464313185 0.135337569976868 1 26.3955 27.7352 32.5189 29.9884 GeneID:10313,Genbank:XM_011544731.2,HGNC:HGNC:10469,MIM:604249 reticulon 3 GO:0000139,GO:0005615,GO:0005783,GO:0005789,GO:0005886,GO:0006915,GO:0016021,GO:0016032,GO:0016192,GO:0070062,GO:0071786,GO:0071787 Golgi membrane|extracellular space|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|apoptotic process|integral component of membrane|viral process|vesicle-mediated transport|extracellular exosome|endoplasmic reticulum tubular network organization|endoplasmic reticulum tubular network formation hsa05010 Alzheimer disease RTN4 12377.1316724462 11644.8708577847 13109.3924871077 1.12576538178986 0.170906189943007 0.187865625651945 1 67.4836 69.5839 84.0162 71.4316 GeneID:57142,Genbank:NM_001321904.1,HGNC:HGNC:14085,MIM:604475 reticulon 4 hsa05010 Alzheimer disease RTN4IP1 225.108796264883 226.80293855347 223.414653976297 0.985060667208358 -0.0217155159169304 0.921421949453461 1 1.50717 1.60992 1.58748 1.51461 GeneID:84816,Genbank:XM_017011375.2,HGNC:HGNC:18647,MIM:610502 reticulon 4 interacting protein 1 GO:0005741,GO:0007399,GO:0008270,GO:0016491,GO:0050773 mitochondrial outer membrane|nervous system development|zinc ion binding|oxidoreductase activity|regulation of dendrite development RTN4R 41.473345326505 34.9675573274966 47.9791333255134 1.37210423010546 0.456390078117652 0.328444955050983 1 0.968433 1.51059 1.71177 1.702 GeneID:65078,Genbank:NM_023004.5,HGNC:HGNC:18601,MIM:605566 reticulon 4 receptor RTN4RL1 36.3171150773979 35.3135499053991 37.3206802493966 1.05683739950739 0.0797534268914874 0.947773528788025 1 0.299103 0.615705 0.566179 0.40677 GeneID:146760,Genbank:NM_178568.3,HGNC:HGNC:21329,MIM:610461 reticulon 4 receptor like 1 GO:0004860,GO:0004872,GO:0005576,GO:0005737,GO:0005886,GO:0006469,GO:0006501,GO:0008201,GO:0009897,GO:0009986,GO:0010977,GO:0019221,GO:0022038,GO:0031103,GO:0035374,GO:0042995,GO:0043204,GO:0045121,GO:0046426,GO:0046658,GO:0048681,GO:0070062 protein kinase inhibitor activity|receptor activity|extracellular region|cytoplasm|plasma membrane|negative regulation of protein kinase activity|C-terminal protein lipidation|heparin binding|external side of plasma membrane|cell surface|negative regulation of neuron projection development|cytokine-mediated signaling pathway|corpus callosum development|axon regeneration|chondroitin sulfate binding|cell projection|perikaryon|membrane raft|negative regulation of JAK-STAT cascade|anchored component of plasma membrane|negative regulation of axon regeneration|extracellular exosome RTN4RL2 19.8392821323832 17.3828217868244 22.2957424779419 1.28263079213303 0.359105947501484 0.603150715684814 1 0.530511 0.520584 0.828082 0.568219 GeneID:349667,Genbank:NM_178570.2,HGNC:HGNC:23053,MIM:610462 reticulon 4 receptor like 2 GO:0004860,GO:0004872,GO:0005576,GO:0005737,GO:0005886,GO:0006469,GO:0006501,GO:0007166,GO:0009897,GO:0009986,GO:0010977,GO:0019221,GO:0022038,GO:0030424,GO:0030425,GO:0031103,GO:0043005,GO:0043204,GO:0045121,GO:0046426,GO:0046658,GO:0070062 protein kinase inhibitor activity|receptor activity|extracellular region|cytoplasm|plasma membrane|negative regulation of protein kinase activity|C-terminal protein lipidation|cell surface receptor signaling pathway|external side of plasma membrane|cell surface|negative regulation of neuron projection development|cytokine-mediated signaling pathway|corpus callosum development|axon|dendrite|axon regeneration|neuron projection|perikaryon|membrane raft|negative regulation of JAK-STAT cascade|anchored component of plasma membrane|extracellular exosome RTP1 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0435526 0 0 GeneID:132112,Genbank:NM_153708.2,HGNC:HGNC:28580,MIM:609137 receptor transporter protein 1 GO:0001580,GO:0005622,GO:0005886,GO:0006612,GO:0009986,GO:0016021,GO:0031849,GO:0051205 detection of chemical stimulus involved in sensory perception of bitter taste|intracellular|plasma membrane|protein targeting to membrane|cell surface|integral component of membrane|olfactory receptor binding|protein insertion into membrane RTP3 4.5536107156875 4.74682654041085 4.36039489096415 0.918591579836145 -0.122504535565728 1 1 0.135556 0 0.0429627 0.200495 GeneID:83597,Genbank:NM_031440.1,HGNC:HGNC:15572,MIM:607181 receptor transporter protein 3 GO:0001580,GO:0005737,GO:0006612,GO:0009986,GO:0016021,GO:0031849,GO:0051205 detection of chemical stimulus involved in sensory perception of bitter taste|cytoplasm|protein targeting to membrane|cell surface|integral component of membrane|olfactory receptor binding|protein insertion into membrane RTP4 28.2742948145003 15.3264836296251 41.2221059993755 2.68959971481624 1.42739147671482 0.433337626479367 1 0.558502 0.636676 3.15391 0.366969 GeneID:64108,Genbank:NM_022147.2,HGNC:HGNC:23992,MIM:609350 receptor transporter protein 4 GO:0001580,GO:0005737,GO:0006612,GO:0009986,GO:0016021,GO:0031849,GO:0051205,GO:0051607 detection of chemical stimulus involved in sensory perception of bitter taste|cytoplasm|protein targeting to membrane|cell surface|integral component of membrane|olfactory receptor binding|protein insertion into membrane|defense response to virus RTRAF 1957.56450626528 2011.10954339691 1904.01946913366 0.946750750293607 -0.0789434354510907 0.581284673688995 1 84.9668 84.4383 78.4575 81.2808 GeneID:51637,Genbank:NM_016039.2,HGNC:HGNC:23169,MIM:610858 RNA transcription, translation and transport factor GO:0000993,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0006351,GO:0006388,GO:0006469,GO:0016032,GO:0042802,GO:0045944,GO:0048471,GO:0050658,GO:0072669,GO:0072686 RNA polymerase II core binding|RNA binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|transcription, DNA-templated|tRNA splicing, via endonucleolytic cleavage and ligation|negative regulation of protein kinase activity|viral process|identical protein binding|positive regulation of transcription from RNA polymerase II promoter|perinuclear region of cytoplasm|RNA transport|tRNA-splicing ligase complex|mitotic spindle RTTN 219.004885721149 222.334461006061 215.675310436237 0.970048949948242 -0.043870545457942 0.857750216324761 1 0.509447 0.582936 0.572725 0.488787 GeneID:25914,Genbank:NM_001318520.1,HGNC:HGNC:18654,MIM:610436 rotatin GO:0005737,GO:0005813,GO:0007368,GO:0036064,GO:0044782 cytoplasm|centrosome|determination of left/right symmetry|ciliary basal body|cilium organization RUBCN 1449.62786177463 1326.9164606915 1572.33926285776 1.18495723689972 0.244834995641755 0.258175789257407 1 4.79347 4.86912 6.83404 4.88652 GeneID:9711,Genbank:NM_001145642.4,HGNC:HGNC:28991,MIM:613516 RUN and cysteine rich domain containing beclin 1 interacting protein GO:0002376,GO:0005654,GO:0005764,GO:0005769,GO:0005770,GO:0005829,GO:0006909,GO:0006914,GO:0010507,GO:0043231,GO:0043553,GO:0045806,GO:0071985,GO:1901097 immune system process|nucleoplasm|lysosome|early endosome|late endosome|cytosol|phagocytosis|autophagy|negative regulation of autophagy|intracellular membrane-bounded organelle|negative regulation of phosphatidylinositol 3-kinase activity|negative regulation of endocytosis|multivesicular body sorting pathway|negative regulation of autophagosome maturation hsa04140 Autophagy - animal RUBCNL 5.92320425884621 6.51500704950053 5.33140146819188 0.818326277728373 -0.28925191503679 0.855185190263766 1 0.0316104 0.0786817 0.0601499 0.0467435 GeneID:80183,Genbank:NM_001286761.2,HGNC:HGNC:20420 RUN and cysteine rich domain containing beclin 1 interacting protein like RUFY1 1310.98609281999 1326.10880567611 1295.86337996387 0.977192349841296 -0.0332855256837751 0.821135985604537 1 10.2077 9.87053 10.0088 10.4926 GeneID:80230,Genbank:XM_006714921.3,HGNC:HGNC:19760,MIM:610327 RUN and FYVE domain containing 1 GO:0005634,GO:0005768,GO:0005829,GO:0006661,GO:0006897,GO:0008289,GO:0008565,GO:0016607,GO:0017124,GO:0030100,GO:0031901,GO:0042169,GO:0043231,GO:0046872 nucleus|endosome|cytosol|phosphatidylinositol biosynthetic process|endocytosis|lipid binding|protein transporter activity|nuclear speck|SH3 domain binding|regulation of endocytosis|early endosome membrane|SH2 domain binding|intracellular membrane-bounded organelle|metal ion binding hsa04144 Endocytosis RUFY2 178.446474487039 190.633707357995 166.259241616084 0.8721397905978 -0.197368699519761 0.611121642167141 1 1.09188 0.795488 1.06813 0.62737 GeneID:55680,Genbank:NM_001330103.1,HGNC:HGNC:19761,MIM:610328 RUN and FYVE domain containing 2 GO:0005634,GO:0046872 nucleus|metal ion binding RUFY3 526.06623580272 523.867367029619 528.265104575822 1.00839475375444 0.0120605176048695 0.962189521430379 1 1.85749 2.05882 2.05012 1.79176 GeneID:22902,Genbank:XM_011531750.2,HGNC:HGNC:30285,MIM:611194 RUN and FYVE domain containing 3 GO:0005737,GO:0005829,GO:0007015,GO:0012505,GO:0016020,GO:0030027,GO:0030054,GO:0030175,GO:0030335,GO:0030424,GO:0030425,GO:0030426,GO:0043204,GO:0045773,GO:0050771,GO:0071437,GO:0090316,GO:2000114 cytoplasm|cytosol|actin filament organization|endomembrane system|membrane|lamellipodium|cell junction|filopodium|positive regulation of cell migration|axon|dendrite|growth cone|perikaryon|positive regulation of axon extension|negative regulation of axonogenesis|invadopodium|positive regulation of intracellular protein transport|regulation of establishment of cell polarity RUNDC1 753.412472151931 765.334230022233 741.490714281628 0.968845616979771 -0.0456613006218996 0.75531259850627 1 4.95185 5.78104 5.36844 5.06748 GeneID:146923,Genbank:XM_005257078.4,HGNC:HGNC:25418 RUN domain containing 1 GO:0005096,GO:0005622,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity RUNDC3A 1.4614045987367 1.47021420587209 1.45259499160132 0.988015886256304 -0.0173938558720138 1 1 0 0.0433812 0 0.0433001 GeneID:10900,Genbank:XM_017024039.1,HGNC:HGNC:16984,MIM:605448 RUN domain containing 3A GO:0005829,GO:0005886,GO:0007264,GO:0030250,GO:0030695,GO:0051428 cytosol|plasma membrane|small GTPase mediated signal transduction|guanylate cyclase activator activity|GTPase regulator activity|peptide hormone receptor binding RUNDC3B 9.9403488755231 10.6757096385841 9.20498811246207 0.862236649748641 -0.213844208679385 0.856653728809684 1 0.082476 0.0990909 0.0596298 0.0648443 GeneID:154661,Genbank:XM_011515829.2,HGNC:HGNC:30286,MIM:617295 RUN domain containing 3B RUNX1 892.886053493008 989.42604588142 796.346061104595 0.804856577628475 -0.313196371509506 0.0675645037653774 0.916343630061028 4.9467 4.66075 4.41865 3.23483 GeneID:861,Genbank:XM_011529768.2,HGNC:HGNC:10471,MIM:151385 runt related transcription factor 1 hsa04530,hsa04659,hsa05200,hsa05202,hsa05220,hsa05221 Tight junction|Th17 cell differentiation|Pathways in cancer|Transcriptional misregulation in cancer|Chronic myeloid leukemia|Acute myeloid leukemia RUNX1T1 22.9743042863574 19.295081119969 26.6535274527458 1.38136384537723 0.466093369403877 0.461213915478722 1 0.0314891 0.0498479 0.0603648 0.0586358 GeneID:862,Genbank:NM_001198633.1,HGNC:HGNC:1535,MIM:133435 RUNX1 translocation partner 1 GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0010977,GO:0016363,GO:0017053,GO:0042803,GO:0045444,GO:0045599,GO:0045892,GO:0046872,GO:0051101 DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of neuron projection development|nuclear matrix|transcriptional repressor complex|protein homodimerization activity|fat cell differentiation|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|metal ion binding|regulation of DNA binding hsa05200,hsa05202,hsa05221 Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia RUNX2 737.802514574347 819.833948840559 655.771080308136 0.799882807043491 -0.322139452490233 0.195698581619743 1 6.31357 4.88652 5.21193 3.99306 GeneID:860,Genbank:NM_001024630.3,HGNC:HGNC:10472,MIM:600211 runt related transcription factor 2 GO:0000790,GO:0000978,GO:0001077,GO:0001501,GO:0001649,GO:0001958,GO:0002051,GO:0002062,GO:0002063,GO:0002076,GO:0003677,GO:0003682,GO:0003700,GO:0005524,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0008284,GO:0010628,GO:0019904,GO:0030182,GO:0030217,GO:0030278,GO:0030509,GO:0032332,GO:0035115,GO:0040036,GO:0042475,GO:0042487,GO:0043234,GO:0043425,GO:0044212,GO:0045667,GO:0045669,GO:0045879,GO:0045892,GO:0045893,GO:0045944,GO:0048469,GO:0048701,GO:0048705,GO:0048863,GO:0070491,GO:0071773,GO:1901522 nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|skeletal system development|osteoblast differentiation|endochondral ossification|osteoblast fate commitment|chondrocyte differentiation|chondrocyte development|osteoblast development|DNA binding|chromatin binding|DNA binding transcription factor activity|ATP binding|nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytosol|positive regulation of cell proliferation|positive regulation of gene expression|protein domain specific binding|neuron differentiation|T cell differentiation|regulation of ossification|BMP signaling pathway|positive regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|regulation of fibroblast growth factor receptor signaling pathway|odontogenesis of dentin-containing tooth|regulation of odontogenesis of dentin-containing tooth|protein complex|bHLH transcription factor binding|transcription regulatory region DNA binding|regulation of osteoblast differentiation|positive regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|cell maturation|embryonic cranial skeleton morphogenesis|skeletal system morphogenesis|stem cell differentiation|repressing transcription factor binding|cellular response to BMP stimulus|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus hsa04928,hsa05202 Parathyroid hormone synthesis, secretion and action|Transcriptional misregulation in cancer RUNX3 1.78185123348129 2.59443583384164 0.969266633120943 0.373594374729911 -1.42045536256559 0.670799861503385 1 0.0202784 0.0176802 0.00937795 0.00879307 GeneID:864,Genbank:NM_001320672.1,HGNC:HGNC:10473,MIM:600210 runt related transcription factor 3 GO:0000122,GO:0000790,GO:0000977,GO:0000981,GO:0001503,GO:0002062,GO:0003700,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006366,GO:0006468,GO:0030097,GO:0043231,GO:0045595,GO:0045786,GO:0045893,GO:0048935,GO:0050680,GO:0071559 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|ossification|chondrocyte differentiation|DNA binding transcription factor activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|protein phosphorylation|hemopoiesis|intracellular membrane-bounded organelle|regulation of cell differentiation|negative regulation of cell cycle|positive regulation of transcription, DNA-templated|peripheral nervous system neuron development|negative regulation of epithelial cell proliferation|response to transforming growth factor beta hsa04658,hsa05169 Th1 and Th2 cell differentiation|Epstein-Barr virus infection RUSC1 2078.6091237489 2053.90269384893 2103.31555364887 1.02405803349298 0.0342974753575854 0.843134918174729 1 15.8042 18.1506 18.4473 17.1012 GeneID:23623,Genbank:NM_001105203.1,HGNC:HGNC:17153,MIM:617318 RUN and SH3 domain containing 1 GO:0000209,GO:0003779,GO:0005070,GO:0005634,GO:0005769,GO:0005794,GO:0005829,GO:0005874,GO:0014069,GO:0015630,GO:0030054,GO:0031410,GO:0045211 protein polyubiquitination|actin binding|SH3/SH2 adaptor activity|nucleus|early endosome|Golgi apparatus|cytosol|microtubule|postsynaptic density|microtubule cytoskeleton|cell junction|cytoplasmic vesicle|postsynaptic membrane RUSC2 1321.69364231811 1293.70829221884 1349.67899241739 1.04326377169814 0.0611039651538899 0.699757166811973 1 7.81649 8.2137 8.67091 8.43839 GeneID:9853,Genbank:NM_014806.4,HGNC:HGNC:23625,MIM:611053 RUN and SH3 domain containing 2 GO:0005829,GO:0017137,GO:0031410,GO:0070062 cytosol|Rab GTPase binding|cytoplasmic vesicle|extracellular exosome RUVBL1 1806.06126858585 1972.80855580594 1639.31398136577 0.830954415998095 -0.267158758225408 0.133587427022425 1 16.9773 17.0538 12.4839 15.3176 GeneID:8607,Genbank:XM_011513249.3,HGNC:HGNC:10474,MIM:603449 RuvB like AAA ATPase 1 hsa04310 Wnt signaling pathway RUVBL2 4766.956556345 4798.00277173974 4735.91034095026 0.98705869218017 -0.0187922225666185 0.887527312951715 1 53.8095 56.2837 52.4041 57.942 GeneID:10856,Genbank:NM_001321190.1,HGNC:HGNC:10475,MIM:604788 RuvB like AAA ATPase 2 RWDD1 1094.84122360881 1132.75416696872 1056.92828024889 0.933060597849978 -0.099957314583429 0.521042782324498 1 19.9154 19.7342 18.4927 18.8352 GeneID:51389,Genbank:NM_016104.3,HGNC:HGNC:20993 RWD domain containing 1 GO:0002181,GO:0005737,GO:0005844,GO:0007569,GO:0030521,GO:0034599,GO:0071394,GO:2000825 cytoplasmic translation|cytoplasm|polysome|cell aging|androgen receptor signaling pathway|cellular response to oxidative stress|cellular response to testosterone stimulus|positive regulation of androgen receptor activity RWDD2A 159.122712448082 174.788743361943 143.45668153422 0.820743251395528 -0.284997112676048 0.257361477865988 1 1.6142 1.61209 1.40699 1.20395 GeneID:112611,Genbank:NM_001322336.1,HGNC:HGNC:21385 RWD domain containing 2A RWDD2B 300.423503841154 310.574705322 290.272302360307 0.934629567013052 -0.0975334172947683 0.6268082989025 1 5.45 6.06044 5.27964 5.78901 GeneID:10069,Genbank:NM_001320724.1,HGNC:HGNC:1302,MIM:617843 RWD domain containing 2B RWDD3 75.6087334641412 77.06465462029 74.1528123079924 0.962215592522347 -0.0555679166765412 0.893896864523027 1 3.20244 2.53555 2.72621 2.37529 GeneID:25950,Genbank:NM_001278248.1,HGNC:HGNC:21393,MIM:615875 RWD domain containing 3 GO:0005634,GO:0005737,GO:0032088,GO:0033235,GO:1902073 nucleus|cytoplasm|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein sumoylation|positive regulation of hypoxia-inducible factor-1alpha signaling pathway RWDD4 159.802349575432 190.221088196046 129.383610954818 0.680174906903447 -0.556022311943235 0.0243970605358127 0.624239560191094 2.86479 3.03826 1.93391 2.27607 GeneID:201965,Genbank:NM_001307922.1,HGNC:HGNC:23750 RWD domain containing 4 RXRA 788.681837226685 750.142016561555 827.221657891815 1.10275339819461 0.141110206180267 0.387751301188291 1 5.03679 5.27495 5.58477 5.98137 GeneID:6256,Genbank:NM_002957.5,HGNC:HGNC:10477,MIM:180245 retinoid X receptor alpha GO:0003700,GO:0003707,GO:0005634,GO:0006351,GO:0008270,GO:0043565,GO:0046966,GO:0046982 DNA binding transcription factor activity|steroid hormone receptor activity|nucleus|transcription, DNA-templated|zinc ion binding|sequence-specific DNA binding|thyroid hormone receptor binding|protein heterodimerization activity hsa03320,hsa04151,hsa04659,hsa04919,hsa04920,hsa04928,hsa04932,hsa04976,hsa05160,hsa05200,hsa05202,hsa05216,hsa05222,hsa05223,hsa05226 PPAR signaling pathway|PI3K-Akt signaling pathway|Th17 cell differentiation|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Parathyroid hormone synthesis, secretion and action|Non-alcoholic fatty liver disease (NAFLD)|Bile secretion|Hepatitis C|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer RXRB 1045.85767145827 935.95144513913 1155.76389777741 1.2348545469745 0.304341117342889 0.0438537253911368 0.78388534136657 10.1028 8.87845 11.7758 12.6461 GeneID:6257,Genbank:NM_001291989.1,HGNC:HGNC:10478,MIM:180246 retinoid X receptor beta GO:0000977,GO:0001228,GO:0003700,GO:0003707,GO:0003713,GO:0004879,GO:0004886,GO:0005634,GO:0005654,GO:0006367,GO:0008270,GO:0045944 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|steroid hormone receptor activity|transcription coactivator activity|nuclear receptor activity|9-cis retinoic acid receptor activity|nucleus|nucleoplasm|transcription initiation from RNA polymerase II promoter|zinc ion binding|positive regulation of transcription from RNA polymerase II promoter hsa03320,hsa04659,hsa04919,hsa04920,hsa04928,hsa05200,hsa05202,hsa05216,hsa05222,hsa05223,hsa05226 PPAR signaling pathway|Th17 cell differentiation|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Parathyroid hormone synthesis, secretion and action|Pathways in cancer|Transcriptional misregulation in cancer|Thyroid cancer|Small cell lung cancer|Non-small cell lung cancer|Gastric cancer RXYLT1 320.664259016607 342.313676589643 299.014841443571 0.87351123221998 -0.195101840441518 0.312369746962045 1 4.03727 5.02227 4.23031 3.61541 GeneID:10329,Genbank:NM_014254.2,HGNC:HGNC:13530,MIM:605862 ribitol xylosyltransferase 1 GO:0000139,GO:0005654,GO:0005794,GO:0005887,GO:0035269,GO:0120053 Golgi membrane|nucleoplasm|Golgi apparatus|integral component of plasma membrane|protein O-linked mannosylation|ribitol beta-1,4-xylosyltransferase activity hsa00515 Mannose type O-glycan biosynthesis RYBP 536.488838600304 563.54149927624 509.436177924369 0.903990528787393 -0.145620437449377 0.678170287114989 1 6.32985 5.04192 6.45082 4.029 GeneID:23429,Genbank:NM_012234.6,HGNC:HGNC:10480,MIM:607535 RING1 and YY1 binding protein GO:0000122,GO:0003677,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006915,GO:0031519,GO:0032435,GO:0035518,GO:0043065,GO:0045893,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|apoptotic process|PcG protein complex|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|histone H2A monoubiquitination|positive regulation of apoptotic process|positive regulation of transcription, DNA-templated|metal ion binding RYK 1101.14737631891 1088.6291404832 1113.66561215463 1.02299816415011 0.0328035560569427 0.811315779233108 1 14.1243 12.7268 13.7972 13.4183 GeneID:6259,Genbank:NM_002958.3,HGNC:HGNC:10481,MIM:600524 receptor-like tyrosine kinase GO:0004888,GO:0005109,GO:0005524,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0007165,GO:0007409,GO:0007411,GO:0007416,GO:0016020,GO:0016021,GO:0016055,GO:0016301,GO:0017147,GO:0022008,GO:0022038,GO:0030182,GO:0031175,GO:0033278,GO:0035567,GO:0036518,GO:0042813,GO:0043410,GO:0060070,GO:0071679,GO:1904929,GO:1904938,GO:1904948,GO:1904953 transmembrane signaling receptor activity|frizzled binding|ATP binding|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|signal transduction|axonogenesis|axon guidance|synapse assembly|membrane|integral component of membrane|Wnt signaling pathway|kinase activity|Wnt-protein binding|neurogenesis|corpus callosum development|neuron differentiation|neuron projection development|cell proliferation in midbrain|non-canonical Wnt signaling pathway|chemorepulsion of dopaminergic neuron axon|Wnt-activated receptor activity|positive regulation of MAPK cascade|canonical Wnt signaling pathway|commissural neuron axon guidance|coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway|planar cell polarity pathway involved in axon guidance|midbrain dopaminergic neuron differentiation|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation hsa04360 Axon guidance RYR1 1.0012194055454 1.51824048055703 0.484198330533773 0.31892070902768 -1.64873031325362 0.791516662337547 1 0 0.00480729 0 0.00238877 GeneID:6261,Genbank:NM_000540.2,HGNC:HGNC:10483,MIM:180901 ryanodine receptor 1 hsa04020,hsa04371,hsa04713,hsa04730,hsa04921 Calcium signaling pathway|Apelin signaling pathway|Circadian entrainment|Long-term depression|Oxytocin signaling pathway RYR2 19.8723360361323 24.7240841610769 15.0205879111877 0.60752858683577 -0.718975799558447 0.271011262984215 1 0.0501909 0.0409403 0.0229873 0.0349282 GeneID:6262,Genbank:XM_006711802.3,HGNC:HGNC:10484,MIM:180902 ryanodine receptor 2 hsa04020,hsa04024,hsa04260,hsa04261,hsa04371,hsa04713,hsa04911,hsa04921,hsa04972,hsa05410,hsa05412,hsa05414 Calcium signaling pathway|cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Circadian entrainment|Insulin secretion|Oxytocin signaling pathway|Pancreatic secretion|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) RYR3 13.238374025903 15.8165550315825 10.6601930202236 0.673989563399699 -0.569201843165799 0.484257085369815 1 0.0116831 0.0289186 0.0111429 0.0155282 GeneID:6263,Genbank:XM_017022477.1,HGNC:HGNC:10485,MIM:180903 ryanodine receptor 3 hsa04020,hsa04371,hsa04713,hsa04921,hsa04970,hsa05010 Calcium signaling pathway|Apelin signaling pathway|Circadian entrainment|Oxytocin signaling pathway|Salivary secretion|Alzheimer disease S100A1 6.04413991761196 6.75513842292525 5.33314141229868 0.789494023423611 -0.340999750156826 0.854913632964851 1 0.268217 0.321745 0.50094 0.232594 GeneID:6271,Genbank:NM_006271.1,HGNC:HGNC:10486,MIM:176940 S100 calcium binding protein A1 S100A10 5897.73895677147 6208.08118993481 5587.39672360812 0.900019918017019 -0.15197116532682 0.249063493498301 1 282.059 280.399 243.425 268.919 GeneID:6281,Genbank:NM_002966.2,HGNC:HGNC:10487,MIM:114085 S100 calcium binding protein A10 GO:0001765,GO:0005509,GO:0005576,GO:0006900,GO:0019897,GO:0042803,GO:0043547,GO:0044325,GO:0045121,GO:0051099,GO:0051290,GO:0051496,GO:0051894,GO:0072659,GO:1900026 membrane raft assembly|calcium ion binding|extracellular region|vesicle budding from membrane|extrinsic component of plasma membrane|protein homodimerization activity|positive regulation of GTPase activity|ion channel binding|membrane raft|positive regulation of binding|protein heterotetramerization|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|protein localization to plasma membrane|positive regulation of substrate adhesion-dependent cell spreading S100A11 4284.76500575668 4112.902930467 4456.62708104636 1.08357215241652 0.115795222160474 0.394351016235802 1 342.939 347.083 380.766 377.593 GeneID:6282,Genbank:NM_005620.1,HGNC:HGNC:10488,MIM:603114 S100 calcium binding protein A11 GO:0001726,GO:0005509,GO:0005576,GO:0005615,GO:0005634,GO:0005737,GO:0005913,GO:0007165,GO:0008156,GO:0008285,GO:0034774,GO:0042803,GO:0043312,GO:0044548,GO:0048306,GO:0070062,GO:0098641 ruffle|calcium ion binding|extracellular region|extracellular space|nucleus|cytoplasm|cell-cell adherens junction|signal transduction|negative regulation of DNA replication|negative regulation of cell proliferation|secretory granule lumen|protein homodimerization activity|neutrophil degranulation|S100 protein binding|calcium-dependent protein binding|extracellular exosome|cadherin binding involved in cell-cell adhesion S100A13 1513.64297572515 1486.92764375642 1540.35830769388 1.03593360050962 0.0509315346022198 0.884917227527521 1 19.2996 22.4511 18.3181 26.2192 GeneID:6284,Genbank:NM_001024210.1,HGNC:HGNC:10490,MIM:601989 S100 calcium binding protein A13 S100A14 1.99406418998212 1.56626675524197 2.42186162472226 1.54626382550532 0.628786494731991 0.890506436562825 1 0.0387693 0 0.0366332 0.136857 GeneID:57402,Genbank:XM_017001875.1,HGNC:HGNC:18901,MIM:607986 S100 calcium binding protein A14 GO:0005509,GO:0005829,GO:0005886,GO:0006915,GO:0016604,GO:0030054,GO:0032496,GO:0034142,GO:0042379,GO:0042742,GO:0048471,GO:0055074,GO:0070062,GO:0071624,GO:0090026 calcium ion binding|cytosol|plasma membrane|apoptotic process|nuclear body|cell junction|response to lipopolysaccharide|toll-like receptor 4 signaling pathway|chemokine receptor binding|defense response to bacterium|perinuclear region of cytoplasm|calcium ion homeostasis|extracellular exosome|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis S100A16 7401.84911677193 7911.66166197852 6892.03657156534 0.871123774754772 -0.199050374297235 0.121283199978757 1 190.814 206.037 170.093 179.678 GeneID:140576,Genbank:NM_080388.2,HGNC:HGNC:20441,MIM:617437 S100 calcium binding protein A16 GO:0003723,GO:0005509,GO:0005615,GO:0005730,GO:0005829,GO:0005886,GO:0042803,GO:0051592,GO:0070062 RNA binding|calcium ion binding|extracellular space|nucleolus|cytosol|plasma membrane|protein homodimerization activity|response to calcium ion|extracellular exosome S100A2 2487.08922622193 2822.3860236893 2151.79242875457 0.762401886451323 -0.391376405898426 0.198398989670665 1 122.432 129.837 76.9395 117.338 GeneID:6273,Genbank:NM_005978.3,HGNC:HGNC:10492,MIM:176993 S100 calcium binding protein A2 S100A3 171.966134013293 194.689565743455 149.24270228313 0.766567544147635 -0.383515178001846 0.145943416212547 1 8.35172 10.7104 6.62515 8.88401 GeneID:6274,Genbank:NM_002960.1,HGNC:HGNC:10493,MIM:176992 S100 calcium binding protein A3 GO:0005509,GO:0005730,GO:0005829,GO:0008270 calcium ion binding|nucleolus|cytosol|zinc ion binding S100A4 1082.44060907098 1178.34265000757 986.538568134387 0.837225545666233 -0.256311762696839 0.389278333890078 1 64.0541 80.2002 49.8572 70.4009 GeneID:6275,Genbank:NM_019554.2,HGNC:HGNC:10494,MIM:114210 S100 calcium binding protein A4 S100A5 5.12875972440474 2.98845468642911 7.26906476238037 2.43238246020258 1.2823700914689 0.381836527871205 1 0.0177021 0.0642458 0.0333626 0.062171 GeneID:6276,Genbank:XM_017002029.1,HGNC:HGNC:10495,MIM:176991 S100 calcium binding protein A5 GO:0005507,GO:0005509,GO:0005634,GO:0008270,GO:0042803,GO:0043025 copper ion binding|calcium ion binding|nucleus|zinc ion binding|protein homodimerization activity|neuronal cell body S100A6 48436.9433713659 48677.0184574818 48196.8682852499 0.990135998722863 -0.0143013967580276 0.950660294311753 1 2888.07 2916.95 2449.65 3389.67 GeneID:6277,Genbank:XM_017002033.1,HGNC:HGNC:10496,MIM:114110 S100 calcium binding protein A6 GO:0001726,GO:0005509,GO:0005523,GO:0005576,GO:0005634,GO:0005635,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0007409,GO:0008270,GO:0015075,GO:0031234,GO:0042803,GO:0044548,GO:0048146,GO:0048306,GO:0048471,GO:0070062 ruffle|calcium ion binding|tropomyosin binding|extracellular region|nucleus|nuclear envelope|cytoplasm|cytosol|plasma membrane|signal transduction|axonogenesis|zinc ion binding|ion transmembrane transporter activity|extrinsic component of cytoplasmic side of plasma membrane|protein homodimerization activity|S100 protein binding|positive regulation of fibroblast proliferation|calcium-dependent protein binding|perinuclear region of cytoplasm|extracellular exosome S100B 314.395328560658 207.219699785391 421.570957335926 2.03441544299374 1.02461431850023 0.00120827006399735 0.11383325497048 5.91124 5.88715 10.2741 13.6907 GeneID:6285,Genbank:NM_006272.2,HGNC:HGNC:10500,MIM:176990 S100 calcium binding protein B S100P 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.20103 0 GeneID:6286,Genbank:NM_005980.2,HGNC:HGNC:10504,MIM:600614 S100 calcium binding protein P S100PBP 516.988595279673 590.534661004327 443.442529555018 0.750917022890497 -0.413274597638121 0.017005329171965 0.540331203073832 4.12032 4.12686 3.2862 2.89437 GeneID:64766,Genbank:XM_011541962.2,HGNC:HGNC:25768,MIM:611889 S100P binding protein S100Z 119.826236880821 114.626647781628 125.025825980014 1.09072216975408 0.125283663198712 0.670692225086732 1 0.644433 0.549927 0.680658 0.722722 GeneID:170591,Genbank:XM_011543241.2,HGNC:HGNC:30367,MIM:610103 S100 calcium binding protein Z GO:0005509,GO:0042803 calcium ion binding|protein homodimerization activity S1PR1 449.593159976325 495.462843026308 403.723476926341 0.814841077608123 -0.295409383891684 0.0968149862500183 1 7.21705 7.47546 6.80892 5.43542 GeneID:1901,Genbank:NM_001400.4,HGNC:HGNC:3165,MIM:601974 sphingosine-1-phosphate receptor 1 GO:0001525,GO:0001664,GO:0001955,GO:0003245,GO:0003376,GO:0004930,GO:0005654,GO:0005768,GO:0005886,GO:0006935,GO:0007155,GO:0007186,GO:0007193,GO:0007420,GO:0009897,GO:0016021,GO:0016477,GO:0019221,GO:0019226,GO:0030032,GO:0030155,GO:0030182,GO:0030335,GO:0030500,GO:0030595,GO:0031226,GO:0031532,GO:0038036,GO:0043231,GO:0043547,GO:0045121,GO:0045124,GO:0045446,GO:0045944,GO:0046625,GO:0048661,GO:0050927,GO:0051482,GO:0051497,GO:0061384,GO:0072678 angiogenesis|G-protein coupled receptor binding|blood vessel maturation|cardiac muscle tissue growth involved in heart morphogenesis|sphingosine-1-phosphate signaling pathway|G-protein coupled receptor activity|nucleoplasm|endosome|plasma membrane|chemotaxis|cell adhesion|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|brain development|external side of plasma membrane|integral component of membrane|cell migration|cytokine-mediated signaling pathway|transmission of nerve impulse|lamellipodium assembly|regulation of cell adhesion|neuron differentiation|positive regulation of cell migration|regulation of bone mineralization|leukocyte chemotaxis|intrinsic component of plasma membrane|actin cytoskeleton reorganization|sphingosine-1-phosphate receptor activity|intracellular membrane-bounded organelle|positive regulation of GTPase activity|membrane raft|regulation of bone resorption|endothelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter|sphingolipid binding|positive regulation of smooth muscle cell proliferation|positive regulation of positive chemotaxis|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|negative regulation of stress fiber assembly|heart trabecula morphogenesis|T cell migration hsa04068,hsa04071,hsa04080 FoxO signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction S1PR2 167.034770659248 181.409611615922 152.659929702575 0.841520624749393 -0.248929464022533 0.306083859581078 1 2.55441 2.58815 2.27744 2.08225 GeneID:9294,Genbank:NM_004230.3,HGNC:HGNC:3169,MIM:605111 sphingosine-1-phosphate receptor 2 GO:0000187,GO:0001664,GO:0003376,GO:0004930,GO:0005178,GO:0005886,GO:0007186,GO:0008284,GO:0008289,GO:0010800,GO:0016021,GO:0031532,GO:0038036,GO:0046847,GO:0090394,GO:1903142 activation of MAPK activity|G-protein coupled receptor binding|sphingosine-1-phosphate signaling pathway|G-protein coupled receptor activity|integrin binding|plasma membrane|G-protein coupled receptor signaling pathway|positive regulation of cell proliferation|lipid binding|positive regulation of peptidyl-threonine phosphorylation|integral component of membrane|actin cytoskeleton reorganization|sphingosine-1-phosphate receptor activity|filopodium assembly|negative regulation of excitatory postsynaptic potential|positive regulation of establishment of endothelial barrier hsa04071,hsa04080 Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction S1PR3 562.677181355715 575.246394994279 550.107967717152 0.956299722178395 -0.0644652382597767 0.716028997453405 1 6.54504 6.28409 7.20011 5.37068 GeneID:1903,Genbank:NM_005226.3,HGNC:HGNC:3167,MIM:601965 sphingosine-1-phosphate receptor 3 GO:0001816,GO:0004930,GO:0005178,GO:0005886,GO:0005887,GO:0006954,GO:0007186,GO:0007193,GO:0007204,GO:0007219,GO:0008284,GO:0008289,GO:0009653,GO:0032651,GO:0038036,GO:1903141 cytokine production|G-protein coupled receptor activity|integrin binding|plasma membrane|integral component of plasma membrane|inflammatory response|G-protein coupled receptor signaling pathway|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|Notch signaling pathway|positive regulation of cell proliferation|lipid binding|anatomical structure morphogenesis|regulation of interleukin-1 beta production|sphingosine-1-phosphate receptor activity|negative regulation of establishment of endothelial barrier hsa04071,hsa04080 Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction S1PR4 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0932228 0 0 GeneID:8698,Genbank:NM_003775.3,HGNC:HGNC:3170,MIM:603751 sphingosine-1-phosphate receptor 4 GO:0004930,GO:0005739,GO:0005886,GO:0005887,GO:0006955,GO:0007186,GO:0007189,GO:0007202,GO:0007204,GO:0008289,GO:0038036 G-protein coupled receptor activity|mitochondrion|plasma membrane|integral component of plasma membrane|immune response|G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway|activation of phospholipase C activity|positive regulation of cytosolic calcium ion concentration|lipid binding|sphingosine-1-phosphate receptor activity hsa04068,hsa04071,hsa04080 FoxO signaling pathway|Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction S1PR5 105.831739203583 84.2236205509107 127.439857856256 1.5131130319816 0.597519763224404 0.0599409148377614 0.879410748501007 1.57551 1.81703 2.27851 2.71149 GeneID:53637,Genbank:NM_001166215.1,HGNC:HGNC:14299,MIM:605146 sphingosine-1-phosphate receptor 5 GO:0005886,GO:0007186,GO:0016021,GO:0038036,GO:0045664 plasma membrane|G-protein coupled receptor signaling pathway|integral component of membrane|sphingosine-1-phosphate receptor activity|regulation of neuron differentiation hsa04071,hsa04080 Sphingolipid signaling pathway|Neuroactive ligand-receptor interaction SAA1 6.53083979783083 7.24520982488261 5.81646977077905 0.802802114964738 -0.316883677433071 0.855754629641291 1 0.616518 0.482795 0.579087 0.382049 GeneID:6288,Genbank:NM_000331.5,HGNC:HGNC:10513,MIM:104750 serum amyloid A1 GO:0000187,GO:0001664,GO:0005576,GO:0005615,GO:0005881,GO:0006898,GO:0006953,GO:0007186,GO:0007204,GO:0008201,GO:0019221,GO:0030168,GO:0030593,GO:0034364,GO:0042056,GO:0044267,GO:0045087,GO:0045785,GO:0048246,GO:0048247,GO:0050708,GO:0050715,GO:0050716,GO:0050728,GO:0070062,GO:0071682 activation of MAPK activity|G-protein coupled receptor binding|extracellular region|extracellular space|cytoplasmic microtubule|receptor-mediated endocytosis|acute-phase response|G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|heparin binding|cytokine-mediated signaling pathway|platelet activation|neutrophil chemotaxis|high-density lipoprotein particle|chemoattractant activity|cellular protein metabolic process|innate immune response|positive regulation of cell adhesion|macrophage chemotaxis|lymphocyte chemotaxis|regulation of protein secretion|positive regulation of cytokine secretion|positive regulation of interleukin-1 secretion|negative regulation of inflammatory response|extracellular exosome|endocytic vesicle lumen SAA2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0130654 GeneID:6289,Genbank:NM_001127380.2,HGNC:HGNC:10514,MIM:104751 serum amyloid A2 GO:0005615,GO:0006953,GO:0034364,GO:0042056,GO:0060326,GO:0070062 extracellular space|acute-phase response|high-density lipoprotein particle|chemoattractant activity|cell chemotaxis|extracellular exosome SAAL1 526.422122616098 568.203098923244 484.641146308952 0.85293647153167 -0.229489804245735 0.185198812356663 1 12.2431 12.2017 11.2261 9.90244 GeneID:113174,Genbank:NM_138421.2,HGNC:HGNC:25158 serum amyloid A like 1 GO:0005615,GO:0005634 extracellular space|nucleus SAC3D1 442.437938167825 432.254457829771 452.621418505878 1.04711798873831 0.0664240135934845 0.726202990585937 1 20.0153 19.6565 20.6872 22.1312 GeneID:29901,Genbank:NM_013299.3,HGNC:HGNC:30179 SAC3 domain containing 1 GO:0005737,GO:0005815,GO:0005819,GO:0007049,GO:0051301 cytoplasm|microtubule organizing center|spindle|cell cycle|cell division SACM1L 626.286115992055 703.958617917122 548.613614066988 0.779326511677959 -0.359700199095538 0.0618185368484719 0.887969225260202 8.85659 7.16672 6.86377 6.09862 GeneID:22908,Genbank:NM_001319073.1,HGNC:HGNC:17059,MIM:606569 SAC1 like phosphatidylinositide phosphatase GO:0000139,GO:0004438,GO:0005789,GO:0005794,GO:0006661,GO:0016791,GO:0030176,GO:0032281,GO:0034593,GO:0034596,GO:0043812,GO:0046856 Golgi membrane|phosphatidylinositol-3-phosphatase activity|endoplasmic reticulum membrane|Golgi apparatus|phosphatidylinositol biosynthetic process|phosphatase activity|integral component of endoplasmic reticulum membrane|AMPA glutamate receptor complex|phosphatidylinositol bisphosphate phosphatase activity|phosphatidylinositol phosphate 4-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity|phosphatidylinositol dephosphorylation hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system SACS 282.067665572502 287.349244331264 276.78608681374 0.963239306433162 -0.0540338302407738 0.890444697986365 1 0.679167 0.648859 0.831937 0.479296 GeneID:26278,Genbank:NM_014363.5,HGNC:HGNC:10519,MIM:604490 sacsin molecular chaperone GO:0005634,GO:0005737,GO:0005739,GO:0006457,GO:0030424,GO:0030425,GO:0030544,GO:0051087,GO:0070628,GO:0070852,GO:0090084 nucleus|cytoplasm|mitochondrion|protein folding|axon|dendrite|Hsp70 protein binding|chaperone binding|proteasome binding|cell body fiber|negative regulation of inclusion body assembly SAE1 9415.28393866249 9273.57576161026 9556.99211571473 1.03056171226613 0.043430899165901 0.742434963537035 1 66.784 69.1747 70.2821 73.371 GeneID:10055,Genbank:XM_017026136.2,HGNC:HGNC:30660,MIM:613294 SUMO1 activating enzyme subunit 1 GO:0004839,GO:0005634,GO:0005654,GO:0005737,GO:0008022,GO:0008047,GO:0016567,GO:0016925,GO:0031510,GO:0043008,GO:0044388,GO:0046982,GO:1903955 ubiquitin activating enzyme activity|nucleus|nucleoplasm|cytoplasm|protein C-terminus binding|enzyme activator activity|protein ubiquitination|protein sumoylation|SUMO activating enzyme complex|ATP-dependent protein binding|small protein activating enzyme binding|protein heterodimerization activity|positive regulation of protein targeting to mitochondrion hsa04120 Ubiquitin mediated proteolysis SAFB 2359.87479221931 2411.42413320605 2308.32545123257 0.957245728549458 -0.063038777434557 0.646978294936883 1 23.8788 24.5503 24.2187 22.0629 GeneID:6294,Genbank:NM_001201338.1,HGNC:HGNC:10520,MIM:602895 scaffold attachment factor B GO:0001047,GO:0003682,GO:0003690,GO:0003723,GO:0005634,GO:0005654,GO:0006325,GO:0006351,GO:0006357,GO:0030520,GO:0040007,GO:0042445,GO:0043565,GO:0045944,GO:0050684 core promoter binding|chromatin binding|double-stranded DNA binding|RNA binding|nucleus|nucleoplasm|chromatin organization|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|intracellular estrogen receptor signaling pathway|growth|hormone metabolic process|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|regulation of mRNA processing SAFB2 1927.97255407202 2053.58205923293 1802.36304891111 0.877667897811859 -0.188252955600966 0.182414077792499 1 11.2693 10.9384 10.4231 9.49936 GeneID:9667,Genbank:XM_024451802.1,HGNC:HGNC:21605,MIM:608066 scaffold attachment factor B2 GO:0003690,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006357,GO:0016604,GO:0042802,GO:0043231,GO:0043565,GO:0050684,GO:0060008,GO:0060765,GO:0070062 double-stranded DNA binding|RNA binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|nuclear body|identical protein binding|intracellular membrane-bounded organelle|sequence-specific DNA binding|regulation of mRNA processing|Sertoli cell differentiation|regulation of androgen receptor signaling pathway|extracellular exosome SALL1 668.383626965733 662.650575330358 674.116678601109 1.01730339291569 0.0247500018893418 0.880044113671625 1 4.68 4.49833 4.89826 4.62108 GeneID:6299,Genbank:NM_002968.2,HGNC:HGNC:10524,MIM:602218 spalt like transcription factor 1 GO:0000122,GO:0000792,GO:0000978,GO:0001078,GO:0001657,GO:0001658,GO:0001822,GO:0003281,GO:0003337,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0007507,GO:0008013,GO:0008406,GO:0010369,GO:0016575,GO:0021553,GO:0021889,GO:0021983,GO:0022008,GO:0030177,GO:0030325,GO:0031129,GO:0035019,GO:0042473,GO:0042733,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0048566,GO:0060173,GO:0061034,GO:0072073,GO:0072092 negative regulation of transcription from RNA polymerase II promoter|heterochromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|ureteric bud development|branching involved in ureteric bud morphogenesis|kidney development|ventricular septum development|mesenchymal to epithelial transition involved in metanephros morphogenesis|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|heart development|beta-catenin binding|gonad development|chromocenter|histone deacetylation|olfactory nerve development|olfactory bulb interneuron differentiation|pituitary gland development|neurogenesis|positive regulation of Wnt signaling pathway|adrenal gland development|inductive cell-cell signaling|somatic stem cell population maintenance|outer ear morphogenesis|embryonic digit morphogenesis|sequence-specific DNA binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|embryonic digestive tract development|limb development|olfactory bulb mitral cell layer development|kidney epithelium development|ureteric bud invasion SALL2 101.113230033871 95.1394615629196 107.086998504823 1.12557919443345 0.170667566696056 0.584167746134911 1 0.620488 0.692478 0.641688 0.857898 GeneID:6297,Genbank:NM_001291446.1,HGNC:HGNC:10526,MIM:602219 spalt like transcription factor 2 GO:0000122,GO:0000977,GO:0001228,GO:0001654,GO:0003700,GO:0005634,GO:0006366,GO:0007165,GO:0016581,GO:0021915,GO:0043565,GO:0044212,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|eye development|DNA binding transcription factor activity|nucleus|transcription from RNA polymerase II promoter|signal transduction|NuRD complex|neural tube development|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding SALL3 98.3207415503133 95.3413753167673 101.300107783859 1.06249891452997 0.0874613673651314 0.809609213253619 1 0.814657 1.0167 1.12561 0.757841 GeneID:27164,Genbank:NM_171999.3,HGNC:HGNC:10527,MIM:605079 spalt like transcription factor 3 GO:0003700,GO:0005634,GO:0006355,GO:0006366,GO:0007165,GO:0021891,GO:0022008,GO:0035136,GO:0035137,GO:0043565,GO:0044212,GO:0045879,GO:0046872 DNA binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|signal transduction|olfactory bulb interneuron development|neurogenesis|forelimb morphogenesis|hindlimb morphogenesis|sequence-specific DNA binding|transcription regulatory region DNA binding|negative regulation of smoothened signaling pathway|metal ion binding SALL4 20.1399346227235 15.5666150030498 24.7132542423972 1.58758048795806 0.666829736221405 0.28954402462705 1 0.111674 0.0694341 0.131448 0.147367 GeneID:57167,Genbank:NM_001318031.1,HGNC:HGNC:15924,MIM:607343 spalt like transcription factor 4 GO:0000122,GO:0000792,GO:0001833,GO:0001843,GO:0003281,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0006366,GO:0007165,GO:0008134,GO:0022008,GO:0030326,GO:0035019,GO:0043231,GO:0043234,GO:0043565,GO:0044212,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|heterochromatin|inner cell mass cell proliferation|neural tube closure|ventricular septum development|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|signal transduction|transcription factor binding|neurogenesis|embryonic limb morphogenesis|somatic stem cell population maintenance|intracellular membrane-bounded organelle|protein complex|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding SAMD1 1165.40214418678 1220.12216368693 1110.68212468662 0.910304031631053 -0.135579624663651 0.404681041260262 1 27.1146 28.7795 24.3413 27.3549 GeneID:90378,Genbank:NM_138352.2,HGNC:HGNC:17958 sterile alpha motif domain containing 1 GO:0005576,GO:0005737 extracellular region|cytoplasm SAMD10 35.2428812328325 40.4445866432895 30.0411758223755 0.742773713756321 -0.429005334681916 0.37579224675715 1 0.50398 0.457102 0.337179 0.46168 GeneID:140700,Genbank:XM_017027671.1,HGNC:HGNC:16129 sterile alpha motif domain containing 10 SAMD11 443.263018505339 461.543072087627 424.982964923051 0.920787225774596 -0.119060276012655 0.497811850130413 1 6.44355 6.68533 6.12677 6.66677 GeneID:148398,Genbank:NM_152486.2,HGNC:HGNC:28706,MIM:616765 sterile alpha motif domain containing 11 GO:0005634 nucleus SAMD12 44.0837817031805 47.4496650947474 40.7178983116136 0.858128255074259 -0.220734807149157 0.610496167948603 1 0.0787418 0.104247 0.102116 0.0558869 GeneID:401474,Genbank:NM_001349811.1,HGNC:HGNC:31750 sterile alpha motif domain containing 12 SAMD13 33.2134333206589 23.3018962298898 43.1249704114281 1.85070648268148 0.888076105604169 0.0691603716567514 0.918407228165493 0.444425 0.375674 0.680391 0.983515 GeneID:148418,Genbank:NM_001010971.2,HGNC:HGNC:24582 sterile alpha motif domain containing 13 SAMD14 74.3047932131875 72.5295504888348 76.0800359375401 1.04895226048936 0.0689490200290886 0.910198133085666 1 0.304327 0.426644 0.394465 0.384116 GeneID:201191,Genbank:NM_001257359.1,HGNC:HGNC:27312 sterile alpha motif domain containing 14 SAMD15 5.58558630205236 7.29323609956755 3.87793650453717 0.531716847171191 -0.911269916701939 0.519603540224993 1 0.0975749 0.0515994 0.0517769 0.0290516 GeneID:161394,Genbank:NM_001010860.2,HGNC:HGNC:18631 sterile alpha motif domain containing 15 GO:0000027,GO:0006364,GO:0030687 ribosomal large subunit assembly|rRNA processing|preribosome, large subunit precursor SAMD3 1.73338997276965 2.49838328447175 0.968396661067546 0.387609326033535 -1.36732481190406 0.67387226712698 1 0.00982028 0 0 0 GeneID:154075,Genbank:NM_001258275.2,HGNC:HGNC:21574 sterile alpha motif domain containing 3 SAMD4A 617.265572135867 681.023348576206 553.507795695529 0.812758911794626 -0.299100624923531 0.0718506892538015 0.928200388965456 2.96813 3.00912 2.78291 2.10499 GeneID:23034,Genbank:XM_024449515.1,HGNC:HGNC:23023,MIM:610747 sterile alpha motif domain containing 4A GO:0000289,GO:0000932,GO:0001650,GO:0003723,GO:0003729,GO:0005829,GO:0006355,GO:0030054,GO:0030371,GO:0030425,GO:0043488,GO:0045202,GO:0045727 nuclear-transcribed mRNA poly(A) tail shortening|P-body|fibrillar center|RNA binding|mRNA binding|cytosol|regulation of transcription, DNA-templated|cell junction|translation repressor activity|dendrite|regulation of mRNA stability|synapse|positive regulation of translation SAMD4B 2616.41803058193 2501.91383777878 2730.92222338508 1.09153328230105 0.126356120689332 0.367726133648549 1 7.25698 7.71917 8.56116 7.95024 GeneID:55095,Genbank:NM_018028.3,HGNC:HGNC:25492 sterile alpha motif domain containing 4B GO:0000289,GO:0000932,GO:0003723,GO:0003729,GO:0005634,GO:0005829,GO:0006351,GO:0006355,GO:0017148,GO:0030371,GO:0043488 nuclear-transcribed mRNA poly(A) tail shortening|P-body|RNA binding|mRNA binding|nucleus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of translation|translation repressor activity|regulation of mRNA stability SAMD5 86.7330025308164 71.673869198759 101.792135862874 1.42021265212561 0.506106964376094 0.187927634144294 1 0.511582 0.443463 0.893676 0.539575 GeneID:389432,Genbank:NM_001030060.2,HGNC:HGNC:21180 sterile alpha motif domain containing 5 SAMD8 589.084588803557 656.662840301537 521.506337305577 0.794176714896952 -0.33246803293604 0.148099993199369 1 3.88719 3.25619 3.21412 2.46384 GeneID:142891,Genbank:XM_011539312.3,HGNC:HGNC:26320,MIM:611575 sterile alpha motif domain containing 8 GO:0002950,GO:0005783,GO:0005789,GO:0005829,GO:0005887,GO:0006686,GO:0016021,GO:0030148,GO:0030173,GO:0030176,GO:0033188,GO:0046513,GO:0047493,GO:1905373,GO:2000303 ceramide phosphoethanolamine synthase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|integral component of plasma membrane|sphingomyelin biosynthetic process|integral component of membrane|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|sphingomyelin synthase activity|ceramide biosynthetic process|ceramide cholinephosphotransferase activity|ceramide phosphoethanolamine biosynthetic process|regulation of ceramide biosynthetic process SAMD9 265.227016193611 128.905345022438 401.548687364784 3.11506623169806 1.63926283776823 0.371769713888055 1 0.619146 0.532844 3.26505 0.424992 GeneID:54809,Genbank:NM_001193307.1,HGNC:HGNC:1348,MIM:610456 sterile alpha motif domain containing 9 GO:0005737,GO:0005769,GO:0005829,GO:0034058,GO:0043231 cytoplasm|early endosome|cytosol|endosomal vesicle fusion|intracellular membrane-bounded organelle SAMD9L 200.465343345357 110.936399284286 289.994287406429 2.61405894978877 1.3862916757963 0.38697318080365 1 0.52442 0.442375 2.23325 0.358764 GeneID:219285,Genbank:NM_001303500.2,HGNC:HGNC:1349,MIM:611170 sterile alpha motif domain containing 9 like GO:0005769,GO:0034058 early endosome|endosomal vesicle fusion SAMHD1 2363.21846539051 1937.54201517437 2788.89491560665 1.43939842014505 0.525465979992758 0.558381645658245 1 13.0502 12.4494 29.0431 8.85038 GeneID:25939,Genbank:XM_005260384.4,HGNC:HGNC:15925,MIM:606754 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 GO:0003676,GO:0003723,GO:0004540,GO:0005622,GO:0005634,GO:0005654,GO:0005886,GO:0006203,GO:0006955,GO:0008270,GO:0008832,GO:0009264,GO:0016793,GO:0032567,GO:0042802,GO:0045088,GO:0046061,GO:0051289,GO:0051607,GO:0060337 nucleic acid binding|RNA binding|ribonuclease activity|intracellular|nucleus|nucleoplasm|plasma membrane|dGTP catabolic process|immune response|zinc ion binding|dGTPase activity|deoxyribonucleotide catabolic process|triphosphoric monoester hydrolase activity|dGTP binding|identical protein binding|regulation of innate immune response|dATP catabolic process|protein homotetramerization|defense response to virus|type I interferon signaling pathway hsa05170 Human immunodeficiency virus 1 infection SAMM50 1079.19241501344 1110.22170813465 1048.16312189224 0.944102528542091 -0.0829845516274756 0.585944631576331 1 26.1447 26.0903 22.6315 26.3522 GeneID:25813,Genbank:NM_015380.4,HGNC:HGNC:24276,MIM:612058 SAMM50 sorting and assembly machinery component GO:0001401,GO:0005739,GO:0005741,GO:0005743,GO:0016021,GO:0033108,GO:0042407,GO:0045040,GO:0070062 mitochondrial sorting and assembly machinery complex|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|integral component of membrane|mitochondrial respiratory chain complex assembly|cristae formation|protein import into mitochondrial outer membrane|extracellular exosome SAMSN1 1.49422734321456 2.98845468642911 0 0 -Inf 0.224695876647012 1 0 0 0 0 GeneID:64092,Genbank:NM_001256370.1,HGNC:HGNC:10528,MIM:607978 SAM domain, SH3 domain and nuclear localization signals 1 GO:0001726,GO:0001784,GO:0002820,GO:0003723,GO:0005634,GO:0005829,GO:0005886,GO:0050732,GO:0050869 ruffle|phosphotyrosine residue binding|negative regulation of adaptive immune response|RNA binding|nucleus|cytosol|plasma membrane|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of B cell activation SAP130 1359.50812875424 1299.52048845657 1419.49576905191 1.09232273108509 0.127399169213049 0.386434122314789 1 9.75036 9.6211 11.0043 10.1874 GeneID:79595,Genbank:NM_001330299.1,HGNC:HGNC:29813,MIM:609697 Sin3A associated protein 130 GO:0000122,GO:0006351,GO:0016607,GO:0070822 negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|nuclear speck|Sin3-type complex SAP18 2832.14137098965 2919.53278013388 2744.74996184543 0.940133291368479 -0.0890627794123349 0.510705541861738 1 31.9887 33.0781 29.689 32.7771 GeneID:10284,Genbank:NM_005870.4,HGNC:HGNC:10530,MIM:602949 Sin3A associated protein 18 GO:0000118,GO:0000381,GO:0003714,GO:0003723,GO:0004407,GO:0005654,GO:0005829,GO:0006351,GO:0006357,GO:0006397,GO:0008380,GO:0016604,GO:0016607,GO:0043065,GO:0048025,GO:0061574 histone deacetylase complex|regulation of alternative mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|histone deacetylase activity|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|mRNA processing|RNA splicing|nuclear body|nuclear speck|positive regulation of apoptotic process|negative regulation of mRNA splicing, via spliceosome|ASAP complex hsa03013,hsa03015 RNA transport|mRNA surveillance pathway SAP25 11.6082017258121 9.64754055998448 13.5688628916398 1.40645823744136 0.492066714735258 0.603013751520579 1 0.27775 0.504484 0.504191 0.472194 GeneID:100316904,Genbank:NM_001168682.2,HGNC:HGNC:41908 Sin3A associated protein 25 GO:0005634,GO:0005737,GO:0006351,GO:0006355 nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated SAP30 806.088526927431 739.417263647431 872.759790207431 1.18033461364189 0.239195907899341 0.128138139428338 1 27.8551 26.8231 30.9558 33.8745 GeneID:8819,Genbank:NM_003864.3,HGNC:HGNC:10532,MIM:603378 Sin3A associated protein 30 GO:0000118,GO:0000122,GO:0003677,GO:0003714,GO:0004407,GO:0005654,GO:0006351,GO:0006355,GO:0035914,GO:0046872 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|DNA binding|transcription corepressor activity|histone deacetylase activity|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|skeletal muscle cell differentiation|metal ion binding hsa05169 Epstein-Barr virus infection SAP30BP 2476.96684257971 2422.33016556295 2531.60351959648 1.0451108422737 0.0636559596442842 0.64685488445229 1 15.4029 15.2603 16.4995 17.1361 GeneID:29115,Genbank:NM_001301855.1,HGNC:HGNC:30785,MIM:610218 SAP30 binding protein GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0006915,GO:0010942,GO:0045111 nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|positive regulation of cell death|intermediate filament cytoskeleton SAP30L 901.858266360115 888.694902143977 915.021630576253 1.02962403449008 0.0421176358613747 0.800308293285517 1 5.91931 6.34721 6.79396 5.65528 GeneID:79685,Genbank:NM_024632.5,HGNC:HGNC:25663,MIM:610398 SAP30 like GO:0000118,GO:0000122,GO:0003677,GO:0003712,GO:0004407,GO:0005634,GO:0005654,GO:0005730,GO:0006351,GO:0006355,GO:0008270,GO:0010314,GO:0031491,GO:0032266,GO:0042393,GO:0044378,GO:0070273 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|DNA binding|transcription cofactor activity|histone deacetylase activity|nucleus|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|phosphatidylinositol-5-phosphate binding|nucleosome binding|phosphatidylinositol-3-phosphate binding|histone binding|non-sequence-specific DNA binding, bending|phosphatidylinositol-4-phosphate binding SAPCD1 24.5708922363921 23.4557837090526 25.6860007637317 1.09508175392231 0.13103857902784 0.865739339085468 1 0.366713 0.758278 0.984161 0.92233 GeneID:401251,Genbank:NM_001039651.1,HGNC:HGNC:13938 suppressor APC domain containing 1 SAPCD2 1684.15633953879 1746.84269823318 1621.4699808444 0.928228959873953 -0.107447385943385 0.443163297707656 1 21.3803 21.5363 19.5558 21.1856 GeneID:89958,Genbank:NM_178448.3,HGNC:HGNC:28055,MIM:612057 suppressor APC domain containing 2 GO:0000132,GO:0005634,GO:0005730,GO:0005829,GO:0005923,GO:0008284,GO:0016324,GO:0043296,GO:0045179,GO:0090175,GO:0098725,GO:1904777 establishment of mitotic spindle orientation|nucleus|nucleolus|cytosol|bicellular tight junction|positive regulation of cell proliferation|apical plasma membrane|apical junction complex|apical cortex|regulation of establishment of planar polarity|symmetric cell division|negative regulation of protein localization to cell cortex SAR1A 2841.99006988755 2905.08835275709 2778.89178701801 0.956560162578426 -0.064072385569532 0.647684201008684 1 40.7926 41.0729 41.4875 37.3884 GeneID:56681,Genbank:NM_020150.4,HGNC:HGNC:10534,MIM:607691 secretion associated Ras related GTPase 1A GO:0000139,GO:0005525,GO:0005783,GO:0006886,GO:0030127,GO:0070062,GO:0090110 Golgi membrane|GTP binding|endoplasmic reticulum|intracellular protein transport|COPII vesicle coat|extracellular exosome|cargo loading into COPII-coated vesicle hsa04141,hsa05134 Protein processing in endoplasmic reticulum|Legionellosis SAR1B 915.845841528049 949.65382708372 882.037855972378 0.928799348580542 -0.106561134527068 0.500373159318349 1 6.10968 6.04951 5.95462 5.60844 GeneID:51128,Genbank:NM_016103.3,HGNC:HGNC:10535,MIM:607690 secretion associated Ras related GTPase 1B GO:0002474,GO:0003924,GO:0005525,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0012507,GO:0019886,GO:0032580,GO:0046872,GO:0048208 antigen processing and presentation of peptide antigen via MHC class I|GTPase activity|GTP binding|endoplasmic reticulum membrane|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|Golgi cisterna membrane|metal ion binding|COPII vesicle coating hsa04141,hsa05134 Protein processing in endoplasmic reticulum|Legionellosis SARAF 5028.18759662762 4910.60214597605 5145.77304727919 1.04789044078756 0.0674878878725322 0.59218142874171 1 51.4776 49.7537 55.3597 54.3685 GeneID:51669,Genbank:NM_001284239.1,HGNC:HGNC:28789,MIM:614768 store-operated calcium entry associated regulatory factor GO:0005783,GO:0006816,GO:0030176,GO:2001256 endoplasmic reticulum|calcium ion transport|integral component of endoplasmic reticulum membrane|regulation of store-operated calcium entry SARDH 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.0200872 0.00859607 0 0 GeneID:1757,Genbank:XM_017014367.1,HGNC:HGNC:10536,MIM:604455 sarcosine dehydrogenase GO:0005739,GO:0005759,GO:0008480,GO:0042426,GO:1901053 mitochondrion|mitochondrial matrix|sarcosine dehydrogenase activity|choline catabolic process|sarcosine catabolic process hsa00260 Glycine, serine and threonine metabolism SARM1 687.751057901114 636.898322090682 738.603793711547 1.15968871025913 0.213737601530074 0.188581858017265 1 4.07815 3.81568 4.95574 4.38414 GeneID:23098,Genbank:NM_015077.3,HGNC:HGNC:17074,MIM:607732 sterile alpha and TIR motif containing 1 GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0007165,GO:0009749,GO:0030054,GO:0030424,GO:0030425,GO:0031315,GO:0034128,GO:0042981,GO:0045087,GO:0045202,GO:0048814,GO:1901214 cytoplasm|mitochondrion|cytosol|microtubule|signal transduction|response to glucose|cell junction|axon|dendrite|extrinsic component of mitochondrial outer membrane|negative regulation of MyD88-independent toll-like receptor signaling pathway|regulation of apoptotic process|innate immune response|synapse|regulation of dendrite morphogenesis|regulation of neuron death SARNP 939.595809407454 972.504886532084 906.686732282824 0.932321004078483 -0.101101325354433 0.510280063202847 1 28.9235 30.6391 26.3436 28.5562 GeneID:84324,Genbank:NM_033082.3,HGNC:HGNC:24432,MIM:610049 SAP domain containing ribonucleoprotein SARS 5442.9358704123 5320.05291498473 5565.81882583987 1.04619614029832 0.0651533526445677 0.761496320830232 1 76.9227 83.2976 76.8993 93.5601 GeneID:6301,Genbank:NM_001330669.1,HGNC:HGNC:10537,MIM:607529 seryl-tRNA synthetase GO:0000122,GO:0001046,GO:0003723,GO:0004828,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006351,GO:0006412,GO:0006418,GO:0006434,GO:0008033,GO:0016259,GO:0016525,GO:0042803,GO:0070062,GO:0097056,GO:0098619,GO:1904046 negative regulation of transcription from RNA polymerase II promoter|core promoter sequence-specific DNA binding|RNA binding|serine-tRNA ligase activity|ATP binding|nucleus|cytoplasm|cytosol|transcription, DNA-templated|translation|tRNA aminoacylation for protein translation|seryl-tRNA aminoacylation|tRNA processing|selenocysteine metabolic process|negative regulation of angiogenesis|protein homodimerization activity|extracellular exosome|selenocysteinyl-tRNA(Sec) biosynthetic process|selenocysteine-tRNA ligase activity|negative regulation of vascular endothelial growth factor production hsa00970 Aminoacyl-tRNA biosynthesis SARS2 451.172230809412 454.077348199536 448.267113419288 0.987204306043264 -0.0185794075579389 0.890424247013248 1 6.21573 7.26802 7.01039 7.32399 GeneID:54938,Genbank:NM_017827.3,HGNC:HGNC:17697,MIM:612804 seryl-tRNA synthetase 2, mitochondrial GO:0003723,GO:0004828,GO:0005524,GO:0005737,GO:0005739,GO:0005759,GO:0006418,GO:0006434,GO:0097056 RNA binding|serine-tRNA ligase activity|ATP binding|cytoplasm|mitochondrion|mitochondrial matrix|tRNA aminoacylation for protein translation|seryl-tRNA aminoacylation|selenocysteinyl-tRNA(Sec) biosynthetic process hsa00970 Aminoacyl-tRNA biosynthesis SART1 1589.49583452977 1508.06734062463 1670.9243284349 1.10799052762645 0.147945547628286 0.315595042311701 1 12.7459 13.9023 14.8752 15.4066 GeneID:9092,Genbank:NM_005146.4,HGNC:HGNC:10538,MIM:605941 SART1, U4/U6.U5 tri-snRNP-associated protein 1 GO:0000387,GO:0000398,GO:0000481,GO:0003723,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0007050,GO:0015030,GO:0016607,GO:0045292,GO:0045585,GO:0046540,GO:0071013,GO:0097193 spliceosomal snRNP assembly|mRNA splicing, via spliceosome|maturation of 5S rRNA|RNA binding|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|cell cycle arrest|Cajal body|nuclear speck|mRNA cis splicing, via spliceosome|positive regulation of cytotoxic T cell differentiation|U4/U6 x U5 tri-snRNP complex|catalytic step 2 spliceosome|intrinsic apoptotic signaling pathway hsa03040 Spliceosome SART3 1541.68454156978 1452.09333959702 1631.27574354255 1.12339592714836 0.167866477573831 0.246779833366977 1 10.2204 10.2596 12.0619 11.2289 GeneID:9733,Genbank:NM_014706.3,HGNC:HGNC:16860,MIM:611684 squamous cell carcinoma antigen recognized by T cells 3 GO:0000244,GO:0000387,GO:0000398,GO:0000902,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0006334,GO:0010468,GO:0015030,GO:0016607,GO:0017070,GO:0030621,GO:0030624,GO:0042393,GO:0048872,GO:0071425,GO:1903586,GO:1990381 spliceosomal tri-snRNP complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|cell morphogenesis|RNA binding|nucleus|nucleoplasm|cytoplasm|nucleosome assembly|regulation of gene expression|Cajal body|nuclear speck|U6 snRNA binding|U4 snRNA binding|U6atac snRNA binding|histone binding|homeostasis of number of cells|hematopoietic stem cell proliferation|positive regulation of histone deubiquitination|ubiquitin-specific protease binding SASH1 576.873178242062 495.049206863505 658.69714962062 1.3305690434168 0.41204337395324 0.0714385675054714 0.926484731519311 1.67722 1.56337 2.58437 1.83614 GeneID:23328,Genbank:XM_017010599.1,HGNC:HGNC:19182,MIM:607955 SAM and SH3 domain containing 1 GO:0000209,GO:0008022,GO:0010595,GO:0019901,GO:0031435,GO:0031666,GO:0032947,GO:0043234,GO:0043507,GO:0045766,GO:1900044,GO:1900745,GO:1901224,GO:1902498 protein polyubiquitination|protein C-terminus binding|positive regulation of endothelial cell migration|protein kinase binding|mitogen-activated protein kinase kinase kinase binding|positive regulation of lipopolysaccharide-mediated signaling pathway|protein complex scaffold activity|protein complex|positive regulation of JUN kinase activity|positive regulation of angiogenesis|regulation of protein K63-linked ubiquitination|positive regulation of p38MAPK cascade|positive regulation of NIK/NF-kappaB signaling|regulation of protein autoubiquitination SASS6 106.574431704279 122.524608141884 90.6242552666747 0.739641257711522 -0.435102393352821 0.339122051986549 1 1.08097 0.634084 0.558428 0.639389 GeneID:163786,Genbank:XM_017000486.1,HGNC:HGNC:25403,MIM:609321 SAS-6 centriolar assembly protein GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0007099,GO:0051298,GO:0098536 centrosome|centriole|microtubule organizing center|cytosol|centriole replication|centrosome duplication|deuterosome SAT1 1371.62251273403 1307.39003985236 1435.85498561571 1.0982606122484 0.135220439939818 0.354048682575194 1 18.5338 19.3315 19.3426 22.3517 GeneID:6303,Genbank:NM_002970.3,HGNC:HGNC:10540,MIM:313020 spermidine/spermine N1-acetyltransferase 1 GO:0001525,GO:0004145,GO:0005622,GO:0005829,GO:0006596,GO:0009447,GO:0019809,GO:0032918,GO:0042127,GO:0042802,GO:0046208 angiogenesis|diamine N-acetyltransferase activity|intracellular|cytosol|polyamine biosynthetic process|putrescine catabolic process|spermidine binding|spermidine acetylation|regulation of cell proliferation|identical protein binding|spermine catabolic process hsa00330,hsa04216 Arginine and proline metabolism|Ferroptosis SAT2 918.556780704476 829.657028191632 1007.45653321732 1.21430482595107 0.280130625618024 0.121995329843048 1 19.2088 21.2675 22.3953 27.5763 GeneID:112483,Genbank:XM_017024074.1,HGNC:HGNC:23160,MIM:611463 spermidine/spermine N1-acetyltransferase family member 2 GO:0004145,GO:0005737,GO:0009447,GO:0032918,GO:0032919,GO:0032920,GO:0042802,GO:0046204,GO:0070062 diamine N-acetyltransferase activity|cytoplasm|putrescine catabolic process|spermidine acetylation|spermine acetylation|putrescine acetylation|identical protein binding|nor-spermidine metabolic process|extracellular exosome hsa00330,hsa04216 Arginine and proline metabolism|Ferroptosis SATB1 298.646754750142 312.313459865766 284.980049634518 0.912480844588012 -0.132133821714687 0.527993261350471 1 1.05474 0.917024 1.0943 0.839721 GeneID:6304,Genbank:NM_001322874.1,HGNC:HGNC:10541,MIM:602075 SATB homeobox 1 SATB2 330.359853455075 375.733567471259 284.986139438892 0.758479316492509 -0.398818255747349 0.0405639742128898 0.759435523043776 1.86913 1.84653 1.61985 1.25825 GeneID:23314,Genbank:NM_015265.3,HGNC:HGNC:21637,MIM:608148 SATB homeobox 2 GO:0000118,GO:0000122,GO:0000978,GO:0001077,GO:0001764,GO:0002076,GO:0003682,GO:0005634,GO:0005654,GO:0005667,GO:0006338,GO:0006357,GO:0009880,GO:0016363,GO:0016569,GO:0021902,GO:0043565,GO:0048704,GO:0051216,GO:0060021,GO:0071310 histone deacetylase complex|negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|neuron migration|osteoblast development|chromatin binding|nucleus|nucleoplasm|transcription factor complex|chromatin remodeling|regulation of transcription from RNA polymerase II promoter|embryonic pattern specification|nuclear matrix|covalent chromatin modification|commitment of neuronal cell to specific neuron type in forebrain|sequence-specific DNA binding|embryonic skeletal system morphogenesis|cartilage development|palate development|cellular response to organic substance SATL1 3.33974336761458 4.25675513845349 2.42273159677566 0.569149861332135 -0.813119520151431 0.728723389322929 1 0.0812962 0 0.0109456 0.0203807 GeneID:340562,Genbank:NM_001012980.2,HGNC:HGNC:27992 spermidine/spermine N1-acetyl transferase like 1 GO:0004145,GO:0005829,GO:0019809,GO:0032918,GO:0046208 diamine N-acetyltransferase activity|cytosol|spermidine binding|spermidine acetylation|spermine catabolic process SAV1 407.343307876232 409.989522332734 404.697093419729 0.987091306912204 -0.018744553329537 0.943550447274939 1 4.41668 4.0058 4.71734 3.70594 GeneID:60485,Genbank:XM_011537057.3,HGNC:HGNC:17795,MIM:607203 salvador family WW domain containing protein 1 hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species SAXO1 25.8537765951592 27.4724074740813 24.2351457162372 0.882163157309808 -0.180882585960694 0.757222716212093 1 0.0124642 0.0113328 0.0117606 0.0219579 GeneID:158297,Genbank:NM_001287049.1,HGNC:HGNC:28566,MIM:616292 stabilizer of axonemal microtubules 1 GO:0005814,GO:0005879,GO:0008017,GO:0009631,GO:0030030,GO:0031514,GO:0036064,GO:0036126,GO:0045724,GO:0050821,GO:0070417 centriole|axonemal microtubule|microtubule binding|cold acclimation|cell projection organization|motile cilium|ciliary basal body|sperm flagellum|positive regulation of cilium assembly|protein stabilization|cellular response to cold SAXO2 5.59015441539585 8.27337890348227 2.90692992730943 0.351359457994351 -1.50898036092531 0.260295469569191 1 0.0565119 0.0214983 0.0108466 0 GeneID:283726,Genbank:NM_001348700.1,HGNC:HGNC:33727 stabilizer of axonemal microtubules 2 GO:0008017 microtubule binding SAYSD1 291.417823774402 292.538115998948 290.297531549856 0.992340880293699 -0.011092307105344 0.978857705044543 1 1.96872 1.81734 2.12349 1.89043 GeneID:55776,Genbank:NM_018322.2,HGNC:HGNC:21025 SAYSVFN motif domain containing 1 GO:0016021,GO:0030659,GO:0043231 integral component of membrane|cytoplasmic vesicle membrane|intracellular membrane-bounded organelle SBDS 2195.97651730251 2110.34983861741 2281.6031959876 1.08114927403808 0.112565729406193 0.400910166212883 1 47.5814 43.0098 49.9046 48.9556 GeneID:51119,Genbank:NM_016038.3,HGNC:HGNC:19440,MIM:607444 SBDS, ribosome maturation factor hsa03008 Ribosome biogenesis in eukaryotes SBF1 3683.88220960003 3509.59902104817 3858.16539815189 1.09931800613496 0.136608783475177 0.323334103593981 1 16.2391 16.9202 19.5144 17.9182 GeneID:6305,Genbank:NM_002972.3,HGNC:HGNC:10542,MIM:603560 SET binding factor 1 GO:0005737,GO:0005789,GO:0005829,GO:0006470,GO:0006661,GO:0007283,GO:0008138,GO:0016021,GO:0016604,GO:0017112,GO:0019208,GO:0043087 cytoplasm|endoplasmic reticulum membrane|cytosol|protein dephosphorylation|phosphatidylinositol biosynthetic process|spermatogenesis|protein tyrosine/serine/threonine phosphatase activity|integral component of membrane|nuclear body|Rab guanyl-nucleotide exchange factor activity|phosphatase regulator activity|regulation of GTPase activity SBF2 474.37846777338 496.07635894125 452.680576605509 0.912521970552361 -0.132068800198736 0.602764845229973 1 1.53372 1.22636 1.41352 1.10609 GeneID:81846,Genbank:NM_030962.3,HGNC:HGNC:2135,MIM:607697 SET binding factor 2 SBK1 53.4835947171439 49.304089498099 57.6630999361888 1.1695399007097 0.225941082360751 0.5758267920304 1 0.368395 0.355859 0.376691 0.464212 GeneID:388228,Genbank:XM_005255315.4,HGNC:HGNC:17699 SH3 domain binding kinase 1 GO:0004674,GO:0005524,GO:0005737,GO:0018105,GO:0018107 protein serine/threonine kinase activity|ATP binding|cytoplasm|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation SBK2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:646643,Genbank:XM_006723327.3,HGNC:HGNC:34416 SH3 domain binding kinase family member 2 GO:0004674,GO:0005524,GO:0005737,GO:0007266,GO:0007346,GO:0016477,GO:0023014,GO:0030036,GO:0031098,GO:0032147,GO:0042981,GO:0043408,GO:0048365 protein serine/threonine kinase activity|ATP binding|cytoplasm|Rho protein signal transduction|regulation of mitotic cell cycle|cell migration|signal transduction by protein phosphorylation|actin cytoskeleton organization|stress-activated protein kinase signaling cascade|activation of protein kinase activity|regulation of apoptotic process|regulation of MAPK cascade|Rac GTPase binding SBK3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:100130827,Genbank:XM_011526298.2,HGNC:HGNC:44121 SH3 domain binding kinase family member 3 GO:0004674,GO:0005524 protein serine/threonine kinase activity|ATP binding SBNO1 483.572394452407 524.144699021766 443.000089883048 0.84518662634543 -0.242658155652576 0.284571433445926 1 1.95836 1.72169 1.80963 1.30592 GeneID:55206,Genbank:NM_018183.4,HGNC:HGNC:22973,MIM:614274 strawberry notch homolog 1 GO:0006355 regulation of transcription, DNA-templated SBNO2 2259.52840913497 2428.89726689055 2090.15955137939 0.860538475575457 -0.216688396775322 0.147382717095894 1 18.4881 20.4017 17.3088 17.1395 GeneID:22904,Genbank:NM_014963.2,HGNC:HGNC:29158,MIM:615729 strawberry notch homolog 2 SBSN 1.48248120036738 1.02816907859967 1.93679332213509 1.88373037319206 0.913592480292383 0.868302647456973 1 0.0198153 0 0 0.0347412 GeneID:374897,Genbank:XM_011526931.2,HGNC:HGNC:24950,MIM:609969 suprabasin GO:0031012,GO:0070062 extracellular matrix|extracellular exosome SBSPON 4.95100109001347 6.02493564754317 3.87706653248377 0.643503393113377 -0.635980339269768 0.672584403827555 1 0.0206582 0.0460884 0.0264987 0.0247013 GeneID:157869,Genbank:XM_017013145.1,HGNC:HGNC:30362 somatomedin B and thrombospondin type 1 domain containing GO:0005044,GO:0005578,GO:0006955,GO:0030247,GO:0031012 scavenger receptor activity|proteinaceous extracellular matrix|immune response|polysaccharide binding|extracellular matrix SC5D 635.941279788996 641.816619418762 630.065940159229 0.981691531655609 -0.0266583245853541 0.945340887637742 1 4.06764 3.21347 4.07959 3.20055 GeneID:6309,Genbank:NM_006918.4,HGNC:HGNC:10547,MIM:602286 sterol-C5-desaturase GO:0000248,GO:0005506,GO:0005789,GO:0006629,GO:0016021,GO:0033489,GO:0033490,GO:0045540,GO:0050046 C-5 sterol desaturase activity|iron ion binding|endoplasmic reticulum membrane|lipid metabolic process|integral component of membrane|cholesterol biosynthetic process via desmosterol|cholesterol biosynthetic process via lathosterol|regulation of cholesterol biosynthetic process|lathosterol oxidase activity hsa00100 Steroid biosynthesis SCAF1 2924.30521993423 2749.91634213196 3098.6940977365 1.12683213313105 0.172272609797995 0.220685361339993 1 21.6325 23.4222 26.1756 25.5494 GeneID:58506,Genbank:XM_011527194.3,HGNC:HGNC:30403,MIM:617264 SR-related CTD associated factor 1 SCAF11 353.525421993608 357.571499633512 349.479344353704 0.977369126767368 -0.0330245615766494 0.953848447360292 1 1.22255 0.966938 1.29563 0.824607 GeneID:9169,Genbank:XM_005269230.2,HGNC:HGNC:10784,MIM:603668 SR-related CTD associated factor 11 GO:0000245,GO:0000375,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006397,GO:0008380,GO:0016604,GO:0046872 spliceosomal complex assembly|RNA splicing, via transesterification reactions|RNA binding|nucleus|nucleoplasm|nucleolus|mRNA processing|RNA splicing|nuclear body|metal ion binding SCAF4 779.707327887054 790.307237210988 769.107418563121 0.973175218889958 -0.0392285111911205 0.807434985478336 1 4.771 4.78508 4.7744 4.49044 GeneID:57466,Genbank:XM_006724036.3,HGNC:HGNC:19304,MIM:616023 SR-related CTD associated factor 4 GO:0003723,GO:0005654 RNA binding|nucleoplasm SCAF8 1081.5757706966 1081.87501906113 1081.27652233207 0.999446796793979 -0.000798324360093621 0.999110692721243 1 6.47421 6.80016 7.41229 6.07337 GeneID:22828,Genbank:NM_014892.4,HGNC:HGNC:20959,MIM:616024 SR-related CTD associated factor 8 GO:0003723,GO:0005654,GO:0005681,GO:0006397,GO:0008380,GO:0016363,GO:0043175 RNA binding|nucleoplasm|spliceosomal complex|mRNA processing|RNA splicing|nuclear matrix|RNA polymerase core enzyme binding SCAI 65.3347184332394 77.3528122683997 53.316624598079 0.689265497071786 -0.53686829551403 0.140923634581065 1 0.296755 0.244358 0.213745 0.149295 GeneID:286205,Genbank:NM_001144877.2,HGNC:HGNC:26709 suppressor of cancer cell invasion GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006355,GO:0016021,GO:0030336,GO:0031965,GO:0035024 transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|integral component of membrane|negative regulation of cell migration|nuclear membrane|negative regulation of Rho protein signal transduction SCAMP1 582.157828072448 654.914277102664 509.401379042233 0.777813825186131 -0.362503216826208 0.095868230296135 1 5.68306 4.97466 4.87583 3.63633 GeneID:9522,Genbank:NM_004866.5,HGNC:HGNC:10563,MIM:606911 secretory carrier membrane protein 1 GO:0005802,GO:0005886,GO:0006892,GO:0015031,GO:0016021,GO:0030136,GO:0030672,GO:0035579,GO:0042589,GO:0043312,GO:0055038 trans-Golgi network|plasma membrane|post-Golgi vesicle-mediated transport|protein transport|integral component of membrane|clathrin-coated vesicle|synaptic vesicle membrane|specific granule membrane|zymogen granule membrane|neutrophil degranulation|recycling endosome membrane SCAMP2 2262.00894576918 2362.13086936391 2161.88702217445 0.915227454250497 -0.127797765326816 0.349056630349031 1 27.3656 28.752 26.5032 27.2082 GeneID:10066,Genbank:NM_005697.4,HGNC:HGNC:10564,MIM:606912 secretory carrier membrane protein 2 GO:0005794,GO:0006892,GO:0015031,GO:0016021,GO:0030133,GO:0032588,GO:0043231,GO:0055038,GO:0070062 Golgi apparatus|post-Golgi vesicle-mediated transport|protein transport|integral component of membrane|transport vesicle|trans-Golgi network membrane|intracellular membrane-bounded organelle|recycling endosome membrane|extracellular exosome SCAMP3 2921.26205574919 2952.32934644544 2890.19476505293 0.978954048108719 -0.0306869532622458 0.811220153261643 1 84.9382 84.1551 82.6106 87.7664 GeneID:10067,Genbank:NM_052837.2,HGNC:HGNC:10565,MIM:606913 secretory carrier membrane protein 3 GO:0006892,GO:0015031,GO:0016021,GO:0031625,GO:0043231,GO:0070062 post-Golgi vesicle-mediated transport|protein transport|integral component of membrane|ubiquitin protein ligase binding|intracellular membrane-bounded organelle|extracellular exosome SCAMP4 2406.30636742313 2343.92280925319 2468.68992559307 1.05323004488345 0.0748205820094289 0.611868479322088 1 46.3202 48.0177 52.3513 50.182 GeneID:113178,Genbank:NM_079834.3,HGNC:HGNC:30385,MIM:613764 secretory carrier membrane protein 4 GO:0015031,GO:0016021 protein transport|integral component of membrane SCAMP5 223.188645338617 232.193723975001 214.183566702233 0.92243478004295 -0.116481184619358 0.588891389500814 1 2.47454 2.70757 2.19642 2.59103 GeneID:192683,Genbank:NM_001178111.1,HGNC:HGNC:30386,MIM:613766 secretory carrier membrane protein 5 GO:0000139,GO:0005886,GO:0006887,GO:0015031,GO:0016021,GO:0030054,GO:0030672,GO:0032588,GO:0034976,GO:0045806,GO:0045956,GO:0050715,GO:0055038 Golgi membrane|plasma membrane|exocytosis|protein transport|integral component of membrane|cell junction|synaptic vesicle membrane|trans-Golgi network membrane|response to endoplasmic reticulum stress|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|recycling endosome membrane SCAND1 1125.36725599281 1062.47712773925 1188.25738424638 1.11838396632102 0.161415582819039 0.479551142783566 1 39.5228 49.747 49.0252 51.655 GeneID:51282,Genbank:NM_016558.3,HGNC:HGNC:10566,MIM:610416 SCAN domain containing 1 GO:0003700,GO:0003713,GO:0005634,GO:0042802 DNA binding transcription factor activity|transcription coactivator activity|nucleus|identical protein binding SCAP 2519.03420531821 2459.79915717748 2578.26925345894 1.04816250787621 0.0678624107032066 0.650493095678485 1 20.3099 22.0371 23.7224 21.0708 GeneID:22937,Genbank:NM_001320044.1,HGNC:HGNC:30634,MIM:601510 SREBF chaperone GO:0000139,GO:0001666,GO:0005783,GO:0005789,GO:0005794,GO:0007568,GO:0008203,GO:0012507,GO:0015485,GO:0016021,GO:0032403,GO:0032868,GO:0032933,GO:0042304,GO:0043234,GO:0045540,GO:0045541,GO:0045716,GO:0051082 Golgi membrane|response to hypoxia|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|aging|cholesterol metabolic process|ER to Golgi transport vesicle membrane|cholesterol binding|integral component of membrane|protein complex binding|response to insulin|SREBP signaling pathway|regulation of fatty acid biosynthetic process|protein complex|regulation of cholesterol biosynthetic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|unfolded protein binding SCAPER 108.104354067993 105.68969268681 110.519015449176 1.04569341285414 0.0644599294153062 0.873772896268518 1 0.215838 0.144681 0.190338 0.13739 GeneID:49855,Genbank:NM_020843.3,HGNC:HGNC:13081,MIM:611611 S-phase cyclin A associated protein in the ER GO:0003676,GO:0005634,GO:0005783,GO:0005829,GO:0008270 nucleic acid binding|nucleus|endoplasmic reticulum|cytosol|zinc ion binding SCARA3 1068.08067683835 936.778717464737 1199.38263621196 1.280326520929 0.356511786828044 0.0191271690112344 0.567297664599869 3.79248 4.11155 4.89135 5.34512 GeneID:51435,Genbank:XM_017013535.1,HGNC:HGNC:19000,MIM:602728 scavenger receptor class A member 3 SCARA5 0.972638154859436 0.490071401957362 1.45520490776151 2.96937324224464 1.5701584476161 0.837389832160054 1 0 0.00981726 0.0308702 0 GeneID:286133,Genbank:NM_173833.5,HGNC:HGNC:28701,MIM:611306 scavenger receptor class A member 5 GO:0005044,GO:0005887,GO:0006879,GO:0006897,GO:0009986,GO:0034605,GO:0034755,GO:0070207,GO:0070287 scavenger receptor activity|integral component of plasma membrane|cellular iron ion homeostasis|endocytosis|cell surface|cellular response to heat|iron ion transmembrane transport|protein homotrimerization|ferritin receptor activity SCARB1 961.555052729118 974.225040766489 948.885064691748 0.973989607108841 -0.0380217166788514 0.800713695536732 1 14.6578 14.2605 14.0825 14.4712 GeneID:949,Genbank:NM_001082959.1,HGNC:HGNC:1664,MIM:601040 scavenger receptor class B member 1 GO:0001530,GO:0001540,GO:0001618,GO:0001786,GO:0001875,GO:0001935,GO:0005044,GO:0005215,GO:0005545,GO:0005765,GO:0005886,GO:0005887,GO:0005901,GO:0006702,GO:0006707,GO:0006898,GO:0008035,GO:0009986,GO:0010595,GO:0010867,GO:0010886,GO:0010899,GO:0015914,GO:0015920,GO:0030169,GO:0030666,GO:0031528,GO:0032497,GO:0033344,GO:0034185,GO:0034186,GO:0034375,GO:0034383,GO:0034384,GO:0035461,GO:0042060,GO:0042632,GO:0042803,GO:0043231,GO:0043534,GO:0043654,GO:0043691,GO:0044406,GO:0050764,GO:0050892,GO:0051000,GO:0070062,GO:0070328,GO:0070506,GO:0070508 lipopolysaccharide binding|amyloid-beta binding|virus receptor activity|phosphatidylserine binding|lipopolysaccharide receptor activity|endothelial cell proliferation|scavenger receptor activity|transporter activity|1-phosphatidylinositol binding|lysosomal membrane|plasma membrane|integral component of plasma membrane|caveola|androgen biosynthetic process|cholesterol catabolic process|receptor-mediated endocytosis|high-density lipoprotein particle binding|cell surface|positive regulation of endothelial cell migration|positive regulation of triglyceride biosynthetic process|positive regulation of cholesterol storage|regulation of phosphatidylcholine catabolic process|phospholipid transport|lipopolysaccharide transport|low-density lipoprotein particle binding|endocytic vesicle membrane|microvillus membrane|detection of lipopolysaccharide|cholesterol efflux|apolipoprotein binding|apolipoprotein A-I binding|high-density lipoprotein particle remodeling|low-density lipoprotein particle clearance|high-density lipoprotein particle clearance|vitamin transmembrane transport|wound healing|cholesterol homeostasis|protein homodimerization activity|intracellular membrane-bounded organelle|blood vessel endothelial cell migration|recognition of apoptotic cell|reverse cholesterol transport|adhesion of symbiont to host|regulation of phagocytosis|intestinal absorption|positive regulation of nitric-oxide synthase activity|extracellular exosome|triglyceride homeostasis|high-density lipoprotein particle receptor activity|cholesterol import hsa04145,hsa04913,hsa04925,hsa04927,hsa04934,hsa04975,hsa04976,hsa04977,hsa04979,hsa05160 Phagosome|Ovarian steroidogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome|Fat digestion and absorption|Bile secretion|Vitamin digestion and absorption|Cholesterol metabolism|Hepatitis C SCARB2 5593.0060717134 5242.9625410491 5943.04960237771 1.13352890772104 0.180821183750947 0.204632372955062 1 44.7493 44.1529 57.2968 44.5912 GeneID:950,Genbank:NM_001204255.1,HGNC:HGNC:1665,MIM:602257 scavenger receptor class B member 2 GO:0000139,GO:0001508,GO:0001618,GO:0002532,GO:0005044,GO:0005765,GO:0005789,GO:0005886,GO:0005925,GO:0006622,GO:0006631,GO:0006911,GO:0009986,GO:0010008,GO:0010976,GO:0016020,GO:0016021,GO:0019899,GO:0030665,GO:0031664,GO:0031902,GO:0043202,GO:0061024,GO:0070062,GO:0099600,GO:1904978,GO:1905123,GO:1905671 Golgi membrane|action potential|virus receptor activity|production of molecular mediator involved in inflammatory response|scavenger receptor activity|lysosomal membrane|endoplasmic reticulum membrane|plasma membrane|focal adhesion|protein targeting to lysosome|fatty acid metabolic process|phagocytosis, engulfment|cell surface|endosome membrane|positive regulation of neuron projection development|membrane|integral component of membrane|enzyme binding|clathrin-coated vesicle membrane|regulation of lipopolysaccharide-mediated signaling pathway|late endosome membrane|lysosomal lumen|membrane organization|extracellular exosome|transmembrane receptor activity|regulation of endosome organization|regulation of glucosylceramidase activity|regulation of lysosome organization hsa04142 Lysosome SCARF1 6.42760921895726 6.07296192222811 6.78225651568641 1.11679549493998 0.159365026960295 0.979059319183725 1 0.0679907 0.0583147 0.0469855 0.131973 GeneID:8578,Genbank:NM_145350.2,HGNC:HGNC:16820,MIM:607873 scavenger receptor class F member 1 GO:0004888,GO:0005044,GO:0005886,GO:0006707,GO:0006898,GO:0007155,GO:0010976,GO:0016021,GO:0016322,GO:0016358,GO:0030169,GO:0030666,GO:0048680 transmembrane signaling receptor activity|scavenger receptor activity|plasma membrane|cholesterol catabolic process|receptor-mediated endocytosis|cell adhesion|positive regulation of neuron projection development|integral component of membrane|neuron remodeling|dendrite development|low-density lipoprotein particle binding|endocytic vesicle membrane|positive regulation of axon regeneration SCARF2 255.057568115529 268.775574332424 241.339561898634 0.897922225626586 -0.155337604889816 0.447590615888301 1 4.53993 4.56705 4.14005 4.34521 GeneID:91179,Genbank:NM_182895.4,HGNC:HGNC:19869,MIM:613619 scavenger receptor class F member 2 GO:0005925,GO:0007157,GO:0016021 focal adhesion|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|integral component of membrane SCCPDH 1454.92316457109 1463.21109436287 1446.6352347793 0.988671586999694 -0.0164367230340809 0.907958923678287 1 28.1319 29.5563 29.8995 27.6576 GeneID:51097,Genbank:NM_016002.2,HGNC:HGNC:24275 saccharopine dehydrogenase (putative) GO:0002576,GO:0005576,GO:0005634,GO:0005739,GO:0005811,GO:0016020,GO:0016491,GO:0030496,GO:0031093 platelet degranulation|extracellular region|nucleus|mitochondrion|lipid droplet|membrane|oxidoreductase activity|midbody|platelet alpha granule lumen SCD 35778.2022897169 32394.5296227983 39161.8749566356 1.2089039542366 0.273699628994982 0.0319538891660871 0.70845034327151 262.552 256.397 324.092 309.27 GeneID:6319,Genbank:NM_005063.4,HGNC:HGNC:10571,MIM:604031 stearoyl-CoA desaturase GO:0004768,GO:0005506,GO:0005730,GO:0005783,GO:0005789,GO:0006636,GO:0016020,GO:0016021,GO:0016491,GO:0045540,GO:0046949,GO:1903966 stearoyl-CoA 9-desaturase activity|iron ion binding|nucleolus|endoplasmic reticulum|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|membrane|integral component of membrane|oxidoreductase activity|regulation of cholesterol biosynthetic process|fatty-acyl-CoA biosynthetic process|monounsaturated fatty acid biosynthetic process hsa01040,hsa03320,hsa04152 Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|AMPK signaling pathway SCD5 884.065349801829 877.346824659804 890.783874943855 1.01531555128072 0.0219281742257409 0.908050836938696 1 9.17028 10.5279 10.9531 9.4891 GeneID:79966,Genbank:NM_001037582.2,HGNC:HGNC:21088,MIM:608370 stearoyl-CoA desaturase 5 GO:0004768,GO:0005789,GO:0006636,GO:0016021,GO:0016491,GO:0046872,GO:0046949,GO:1903966 stearoyl-CoA 9-desaturase activity|endoplasmic reticulum membrane|unsaturated fatty acid biosynthetic process|integral component of membrane|oxidoreductase activity|metal ion binding|fatty-acyl-CoA biosynthetic process|monounsaturated fatty acid biosynthetic process hsa01040,hsa03320,hsa04152 Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|AMPK signaling pathway SCEL 1.26483015846966 1.07619535328461 1.45346496365472 1.35055866875717 0.43355631240266 1 1 0 0 0.00937806 0.0174632 GeneID:8796,Genbank:NM_144777.2,HGNC:HGNC:10573,MIM:604112 sciellin GO:0001533,GO:0005737,GO:0008544,GO:0009612,GO:0009790,GO:0030216,GO:0046872,GO:0048471,GO:0070062,GO:0090263 cornified envelope|cytoplasm|epidermis development|response to mechanical stimulus|embryo development|keratinocyte differentiation|metal ion binding|perinuclear region of cytoplasm|extracellular exosome|positive regulation of canonical Wnt signaling pathway SCFD1 343.277224032563 377.356652155439 309.197795909688 0.819378150997387 -0.287398671519941 0.199501800478118 1 3.20301 2.63337 2.53203 2.32583 GeneID:23256,Genbank:NM_016106.3,HGNC:HGNC:20726 sec1 family domain containing 1 GO:0000902,GO:0001666,GO:0005789,GO:0005798,GO:0005801,GO:0005829,GO:0005886,GO:0006890,GO:0006892,GO:0006904,GO:0006909,GO:0009636,GO:0015031,GO:0017119,GO:0019905,GO:0032580,GO:0047485,GO:0048208,GO:0051223,GO:0060628,GO:1901998,GO:1902902 cell morphogenesis|response to hypoxia|endoplasmic reticulum membrane|Golgi-associated vesicle|cis-Golgi network|cytosol|plasma membrane|retrograde vesicle-mediated transport, Golgi to ER|post-Golgi vesicle-mediated transport|vesicle docking involved in exocytosis|phagocytosis|response to toxic substance|protein transport|Golgi transport complex|syntaxin binding|Golgi cisterna membrane|protein N-terminus binding|COPII vesicle coating|regulation of protein transport|regulation of ER to Golgi vesicle-mediated transport|toxin transport|negative regulation of autophagosome assembly SCFD2 613.659429614029 598.27873388542 629.040125342638 1.05141648819346 0.0723342643789227 0.644026519998864 1 2.04539 1.78003 2.07525 2.01128 GeneID:152579,Genbank:NM_152540.3,HGNC:HGNC:30676 sec1 family domain containing 2 GO:0006904,GO:0015031 vesicle docking involved in exocytosis|protein transport SCG2 227.388892111288 214.88733742733 239.890446795246 1.11635450309571 0.158795233837899 0.462653511303192 1 2.64434 2.51621 2.9662 2.77814 GeneID:7857,Genbank:NM_003469.4,HGNC:HGNC:10575,MIM:118930 secretogranin II GO:0000165,GO:0001525,GO:0001937,GO:0001938,GO:0005125,GO:0005615,GO:0005788,GO:0006954,GO:0009306,GO:0035556,GO:0042056,GO:0043542,GO:0043687,GO:0044267,GO:0048245,GO:0050918,GO:0050930,GO:0098992,GO:2000352,GO:2001237 MAPK cascade|angiogenesis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|cytokine activity|extracellular space|endoplasmic reticulum lumen|inflammatory response|protein secretion|intracellular signal transduction|chemoattractant activity|endothelial cell migration|post-translational protein modification|cellular protein metabolic process|eosinophil chemotaxis|positive chemotaxis|induction of positive chemotaxis|neuronal dense core vesicle|negative regulation of endothelial cell apoptotic process|negative regulation of extrinsic apoptotic signaling pathway SCG3 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0106228 0 0.0102218 0 GeneID:29106,Genbank:NM_013243.3,HGNC:HGNC:13707,MIM:611796 secretogranin III GO:0002576,GO:0003723,GO:0005576,GO:0005788,GO:0030658,GO:0034774,GO:0043687,GO:0044267 platelet degranulation|RNA binding|extracellular region|endoplasmic reticulum lumen|transport vesicle membrane|secretory granule lumen|post-translational protein modification|cellular protein metabolic process SCG5 7.9408466001441 8.12930007942745 7.75239312086075 0.953635988967793 -0.0684894126468183 1 1 0.0646625 0.0600266 0.0615859 0.142847 GeneID:6447,Genbank:NM_001144757.2,HGNC:HGNC:10816,MIM:173120 secretogranin V GO:0004857,GO:0005525,GO:0005576,GO:0006886,GO:0007218,GO:0016486,GO:0030141,GO:0046883,GO:0051082 enzyme inhibitor activity|GTP binding|extracellular region|intracellular protein transport|neuropeptide signaling pathway|peptide hormone processing|secretory granule|regulation of hormone secretion|unfolded protein binding SCGB2B2 4.12460378314755 0.980142803914724 7.26906476238037 7.41633232764397 2.89070589292537 0.101524019469355 1 0 0.0216361 0.0673199 0.0839635 GeneID:284402,Genbank:NM_001025591.3,HGNC:HGNC:27616,MIM:615063 secretoglobin family 2B member 2 GO:0005576 extracellular region SCGB3A2 1.48585272210587 1.51824048055703 1.45346496365472 0.957335140426142 -0.0629040282857778 1 1 0 0 0 0.253649 GeneID:117156,Genbank:NM_054023.4,HGNC:HGNC:18391,MIM:606531 secretoglobin family 3A member 2 GO:0005576,GO:0006898,GO:0071682 extracellular region|receptor-mediated endocytosis|endocytic vesicle lumen SCHIP1 22.9237764619874 18.7089571686417 27.138595755333 1.45056699369756 0.536616927210027 0.396466138177504 1 9.57803 9.5808 12.554 11.3998 GeneID:29970,Genbank:NM_014575.3,HGNC:HGNC:15678 schwannomin interacting protein 1 GO:0005737,GO:0030424,GO:0042802 cytoplasm|axon|identical protein binding SCIMP 1.99700072569391 2.05633815719933 1.93766329418849 0.942288255170796 -0.0857596330424504 1 1 0 0 0 0 GeneID:388325,Genbank:NM_001271842.1,HGNC:HGNC:33504,MIM:614406 SLP adaptor and CSK interacting membrane protein GO:0001772,GO:0016020,GO:0016021,GO:0031256,GO:0031259,GO:0070374,GO:0097197 immunological synapse|membrane|integral component of membrane|leading edge membrane|uropod membrane|positive regulation of ERK1 and ERK2 cascade|tetraspanin-enriched microdomain SCIN 5.22481227377463 3.18055978516888 7.26906476238037 2.28546710433692 1.19248905379142 0.378139717356597 1 0.0552836 0.010395 0.0423249 0.0590414 GeneID:85477,Genbank:NM_001112706.2,HGNC:HGNC:21695,MIM:613416 scinderin GO:0001786,GO:0002102,GO:0003779,GO:0005509,GO:0005545,GO:0005546,GO:0005737,GO:0005886,GO:0005903,GO:0005938,GO:0008285,GO:0017156,GO:0030054,GO:0032330,GO:0042989,GO:0042995,GO:0043065,GO:0045010,GO:0045654,GO:0051014,GO:0051015,GO:0051047,GO:0051127,GO:0051693,GO:0070062 phosphatidylserine binding|podosome|actin binding|calcium ion binding|1-phosphatidylinositol binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|plasma membrane|brush border|cell cortex|negative regulation of cell proliferation|calcium ion regulated exocytosis|cell junction|regulation of chondrocyte differentiation|sequestering of actin monomers|cell projection|positive regulation of apoptotic process|actin nucleation|positive regulation of megakaryocyte differentiation|actin filament severing|actin filament binding|positive regulation of secretion|positive regulation of actin nucleation|actin filament capping|extracellular exosome hsa04666,hsa04810,hsa05203 Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Viral carcinogenesis SCLT1 158.887272877283 156.858015243369 160.916530511198 1.02587381500099 0.0368532868241777 0.874674108062405 1 0.581372 0.492807 0.6941 0.477641 GeneID:132320,Genbank:XM_017007717.2,HGNC:HGNC:26406,MIM:611399 sodium channel and clathrin linker 1 GO:0005813,GO:0005814,GO:0005829,GO:0008022,GO:0017080,GO:0030276,GO:0045162,GO:0060271,GO:0070062,GO:0071439,GO:0097539,GO:0097711 centrosome|centriole|cytosol|protein C-terminus binding|sodium channel regulator activity|clathrin binding|clustering of voltage-gated sodium channels|cilium assembly|extracellular exosome|clathrin complex|ciliary transition fiber|ciliary basal body-plasma membrane docking SCLY 429.384600743839 446.82131271869 411.947888768988 0.921952192169361 -0.117236153244053 0.527003594204561 1 6.86686 6.06055 6.42817 5.64841 GeneID:51540,Genbank:NM_016510.5,HGNC:HGNC:18161,MIM:611056 selenocysteine lyase GO:0001887,GO:0005829,GO:0006520,GO:0009000,GO:0016740 selenium compound metabolic process|cytosol|cellular amino acid metabolic process|selenocysteine lyase activity|transferase activity hsa00450 Selenocompound metabolism SCMH1 1137.13478927021 1055.3641540816 1218.90542445882 1.15496193398717 0.207845303110652 0.169640233784252 1 6.01034 6.39336 8.03614 6.59948 GeneID:22955,Genbank:NM_001172220.1,HGNC:HGNC:19003,MIM:616396 Scm polycomb group protein homolog 1 GO:0005654,GO:0006338,GO:0006351,GO:0007283,GO:0009952,GO:0010369,GO:0016458,GO:0045892 nucleoplasm|chromatin remodeling|transcription, DNA-templated|spermatogenesis|anterior/posterior pattern specification|chromocenter|gene silencing|negative regulation of transcription, DNA-templated SCML1 280.184946637691 340.814036418447 219.555856856935 0.644210136308374 -0.634396733938792 0.00200391417458813 0.159166131464737 1.62337 1.5948 1.13402 0.866905 GeneID:6322,Genbank:NM_001037540.2,HGNC:HGNC:10580,MIM:300227 Scm polycomb group protein like 1 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0009653 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|anatomical structure morphogenesis SCML2 115.06899434283 139.984882168717 90.1531065169418 0.64402030505183 -0.634821919690675 0.0237721213186924 0.61999072858338 1.097 1.06543 0.866942 0.570285 GeneID:10389,Genbank:NM_006089.2,HGNC:HGNC:10581,MIM:300208 Scm polycomb group protein like 2 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0009653,GO:0031519 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|anatomical structure morphogenesis|PcG protein complex SCML4 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00283396 0 0 GeneID:256380,Genbank:XM_017010680.1,HGNC:HGNC:21397 Scm polycomb group protein like 4 GO:0005654,GO:0006351,GO:0006355 nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated SCN11A 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.00508935 0 0 0 GeneID:11280,Genbank:XM_017005647.1,HGNC:HGNC:10583,MIM:604385 sodium voltage-gated channel alpha subunit 11 GO:0001518,GO:0005244,GO:0005248,GO:0005886,GO:0006814,GO:0019228,GO:0034765,GO:0042493,GO:0044299,GO:0051930,GO:0070062,GO:0086010 voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|plasma membrane|sodium ion transport|neuronal action potential|regulation of ion transmembrane transport|response to drug|C-fiber|regulation of sensory perception of pain|extracellular exosome|membrane depolarization during action potential SCN1B 84.1801483187318 79.1886363623902 89.1716602750734 1.12606636976293 0.171291861615318 0.639160096987855 1 0.404976 0.548416 0.562979 0.464861 GeneID:6324,Genbank:NM_001037.4,HGNC:HGNC:10586,MIM:600235 sodium voltage-gated channel beta subunit 1 GO:0001518,GO:0005244,GO:0005248,GO:0005576,GO:0005886,GO:0007155,GO:0007268,GO:0007411,GO:0010765,GO:0010976,GO:0014704,GO:0017080,GO:0019227,GO:0019871,GO:0021966,GO:0030315,GO:0033268,GO:0035725,GO:0040011,GO:0046684,GO:0051899,GO:0060048,GO:0060307,GO:0060371,GO:0061337,GO:0086002,GO:0086006,GO:0086012,GO:0086047,GO:0086062,GO:0086091,GO:2000649 voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|extracellular region|plasma membrane|cell adhesion|chemical synaptic transmission|axon guidance|positive regulation of sodium ion transport|positive regulation of neuron projection development|intercalated disc|sodium channel regulator activity|neuronal action potential propagation|sodium channel inhibitor activity|corticospinal neuron axon guidance|T-tubule|node of Ranvier|sodium ion transmembrane transport|locomotion|response to pyrethroid|membrane depolarization|cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane depolarization|cardiac conduction|cardiac muscle cell action potential involved in contraction|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|membrane depolarization during cardiac muscle cell action potential|membrane depolarization during Purkinje myocyte cell action potential|voltage-gated sodium channel activity involved in Purkinje myocyte action potential|regulation of heart rate by cardiac conduction|regulation of sodium ion transmembrane transporter activity hsa04261 Adrenergic signaling in cardiomyocytes SCN2A 4.28836838513154 4.69880026572591 3.87793650453717 0.825303542443311 -0.277003262031252 0.950525322671129 1 0.023152 0.0111542 0.0148926 0.0103791 GeneID:6326,Genbank:XM_017004656.1,HGNC:HGNC:10588,MIM:182390 sodium voltage-gated channel alpha subunit 2 GO:0001518,GO:0005244,GO:0005248,GO:0005622,GO:0005887,GO:0006814,GO:0008627,GO:0014704,GO:0019228,GO:0030315,GO:0030424,GO:0031226,GO:0033268,GO:0033270,GO:0034706,GO:0034765,GO:0035725,GO:0042552,GO:0051402,GO:0086010 voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|intracellular|integral component of plasma membrane|sodium ion transport|intrinsic apoptotic signaling pathway in response to osmotic stress|intercalated disc|neuronal action potential|T-tubule|axon|intrinsic component of plasma membrane|node of Ranvier|paranode region of axon|sodium channel complex|regulation of ion transmembrane transport|sodium ion transmembrane transport|myelination|neuron apoptotic process|membrane depolarization during action potential hsa04742 Taste transduction SCN2B 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.00793147 0 0.00772887 GeneID:6327,Genbank:NM_004588.4,HGNC:HGNC:10589,MIM:601327 sodium voltage-gated channel beta subunit 2 GO:0001518,GO:0005244,GO:0007268,GO:0007399,GO:0017080,GO:0035725,GO:0046684,GO:0060048,GO:0060371,GO:0086002,GO:0086006,GO:0086012,GO:0086091,GO:2000649 voltage-gated sodium channel complex|voltage-gated ion channel activity|chemical synaptic transmission|nervous system development|sodium channel regulator activity|sodium ion transmembrane transport|response to pyrethroid|cardiac muscle contraction|regulation of atrial cardiac muscle cell membrane depolarization|cardiac muscle cell action potential involved in contraction|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|membrane depolarization during cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|regulation of sodium ion transmembrane transporter activity SCN3A 3.47578378477119 2.10436443188427 4.84720313765811 2.30340480204651 1.2037679736949 0.510004049697326 1 0.003824 0.00369837 0.014788 0.0137322 GeneID:6328,Genbank:NM_001081676.1,HGNC:HGNC:10590,MIM:182391 sodium voltage-gated channel alpha subunit 3 GO:0001518,GO:0005244,GO:0005248,GO:0005737,GO:0005886,GO:0006814,GO:0019228,GO:0034765,GO:0086010 voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|cytoplasm|plasma membrane|sodium ion transport|neuronal action potential|regulation of ion transmembrane transport|membrane depolarization during action potential hsa04742 Taste transduction SCN3B 3.22468078027241 4.99676656894351 1.45259499160132 0.290706994525151 -1.7823623111829 0.340171410232555 1 0 0.0495803 0 0.0203729 GeneID:55800,Genbank:NM_001040151.1,HGNC:HGNC:20665,MIM:608214 sodium voltage-gated channel beta subunit 3 GO:0001518,GO:0005244,GO:0005248,GO:0005886,GO:0006814,GO:0007399,GO:0010460,GO:0010765,GO:0016021,GO:0017080,GO:0019233,GO:0030018,GO:0035725,GO:0044325,GO:0051899,GO:0060048,GO:0060371,GO:0060373,GO:0072659,GO:0086002,GO:0086005,GO:0086006,GO:0086010,GO:0086012,GO:0086014,GO:0086015,GO:0086091,GO:2000649 voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|plasma membrane|sodium ion transport|nervous system development|positive regulation of heart rate|positive regulation of sodium ion transport|integral component of membrane|sodium channel regulator activity|sensory perception of pain|Z disc|sodium ion transmembrane transport|ion channel binding|membrane depolarization|cardiac muscle contraction|regulation of atrial cardiac muscle cell membrane depolarization|regulation of ventricular cardiac muscle cell membrane depolarization|protein localization to plasma membrane|cardiac muscle cell action potential involved in contraction|ventricular cardiac muscle cell action potential|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|membrane depolarization during action potential|membrane depolarization during cardiac muscle cell action potential|atrial cardiac muscle cell action potential|SA node cell action potential|regulation of heart rate by cardiac conduction|regulation of sodium ion transmembrane transporter activity SCN4B 397.356639693666 318.329603859056 476.383675528276 1.4965107541151 0.581602646261857 0.0018518250239175 0.153441233527396 2.27232 2.68992 3.84572 3.8898 GeneID:6330,Genbank:NM_001142348.1,HGNC:HGNC:10592,MIM:608256 sodium voltage-gated channel beta subunit 4 GO:0001518,GO:0005244,GO:0005248,GO:0006814,GO:0010765,GO:0014704,GO:0017080,GO:0031226,GO:0035725,GO:0044325,GO:0060048,GO:0060307,GO:0086002,GO:0086006,GO:0086012,GO:0086016,GO:0086091,GO:2000649 voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|sodium ion transport|positive regulation of sodium ion transport|intercalated disc|sodium channel regulator activity|intrinsic component of plasma membrane|sodium ion transmembrane transport|ion channel binding|cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|cardiac muscle cell action potential involved in contraction|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|membrane depolarization during cardiac muscle cell action potential|AV node cell action potential|regulation of heart rate by cardiac conduction|regulation of sodium ion transmembrane transporter activity hsa04261 Adrenergic signaling in cardiomyocytes SCN5A 11.9908139612988 13.8082431490681 10.1733847735296 0.736761705577021 -0.440730017999215 0.623155070408158 1 0.0488877 0.0431198 0.0182424 0.0511795 GeneID:6331,Genbank:XM_017007017.1,HGNC:HGNC:10593,MIM:600163 sodium voltage-gated channel alpha subunit 5 GO:0001518,GO:0002027,GO:0003231,GO:0003360,GO:0005244,GO:0005248,GO:0005516,GO:0005622,GO:0005783,GO:0005886,GO:0005901,GO:0006814,GO:0009986,GO:0010765,GO:0014704,GO:0014894,GO:0016021,GO:0016328,GO:0017134,GO:0019228,GO:0019899,GO:0019901,GO:0019904,GO:0021537,GO:0021549,GO:0030018,GO:0030315,GO:0030506,GO:0031625,GO:0035725,GO:0042383,GO:0042475,GO:0044325,GO:0045760,GO:0048471,GO:0050679,GO:0050998,GO:0051899,GO:0060048,GO:0060307,GO:0060371,GO:0060372,GO:0060373,GO:0061337,GO:0071277,GO:0086002,GO:0086004,GO:0086005,GO:0086006,GO:0086010,GO:0086012,GO:0086014,GO:0086015,GO:0086016,GO:0086043,GO:0086045,GO:0086046,GO:0086047,GO:0086048,GO:0086060,GO:0086061,GO:0086062,GO:0086063,GO:0086067,GO:0086091,GO:0097110,GO:0098912,GO:1902305 voltage-gated sodium channel complex|regulation of heart rate|cardiac ventricle development|brainstem development|voltage-gated ion channel activity|voltage-gated sodium channel activity|calmodulin binding|intracellular|endoplasmic reticulum|plasma membrane|caveola|sodium ion transport|cell surface|positive regulation of sodium ion transport|intercalated disc|response to denervation involved in regulation of muscle adaptation|integral component of membrane|lateral plasma membrane|fibroblast growth factor binding|neuronal action potential|enzyme binding|protein kinase binding|protein domain specific binding|telencephalon development|cerebellum development|Z disc|T-tubule|ankyrin binding|ubiquitin protein ligase binding|sodium ion transmembrane transport|sarcolemma|odontogenesis of dentin-containing tooth|ion channel binding|positive regulation of action potential|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|nitric-oxide synthase binding|membrane depolarization|cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of atrial cardiac muscle cell membrane depolarization|regulation of atrial cardiac muscle cell membrane repolarization|regulation of ventricular cardiac muscle cell membrane depolarization|cardiac conduction|cellular response to calcium ion|cardiac muscle cell action potential involved in contraction|regulation of cardiac muscle cell contraction|ventricular cardiac muscle cell action potential|voltage-gated sodium channel activity involved in cardiac muscle cell action potential|membrane depolarization during action potential|membrane depolarization during cardiac muscle cell action potential|atrial cardiac muscle cell action potential|SA node cell action potential|AV node cell action potential|bundle of His cell action potential|membrane depolarization during AV node cell action potential|membrane depolarization during SA node cell action potential|membrane depolarization during Purkinje myocyte cell action potential|membrane depolarization during bundle of His cell action potential|voltage-gated sodium channel activity involved in AV node cell action potential|voltage-gated sodium channel activity involved in bundle of His cell action potential|voltage-gated sodium channel activity involved in Purkinje myocyte action potential|voltage-gated sodium channel activity involved in SA node cell action potential|AV node cell to bundle of His cell communication|regulation of heart rate by cardiac conduction|scaffold protein binding|membrane depolarization during atrial cardiac muscle cell action potential|regulation of sodium ion transmembrane transport hsa04261 Adrenergic signaling in cardiomyocytes SCN8A 131.604948043504 133.315987640054 129.893908446954 0.974331066710921 -0.037516027768142 0.917747539219796 1 0.405359 0.362274 0.441965 0.339565 GeneID:6334,Genbank:XM_006719556.4,HGNC:HGNC:10596,MIM:600702 sodium voltage-gated channel alpha subunit 8 GO:0001518,GO:0005244,GO:0005248,GO:0005524,GO:0005886,GO:0006814,GO:0007399,GO:0007422,GO:0016021,GO:0019228,GO:0030018,GO:0031410,GO:0033268,GO:0034765,GO:0042552,GO:0043194,GO:0086010 voltage-gated sodium channel complex|voltage-gated ion channel activity|voltage-gated sodium channel activity|ATP binding|plasma membrane|sodium ion transport|nervous system development|peripheral nervous system development|integral component of membrane|neuronal action potential|Z disc|cytoplasmic vesicle|node of Ranvier|regulation of ion transmembrane transport|myelination|axon initial segment|membrane depolarization during action potential SCN9A 22.0081813272396 20.2654152687757 23.7509473857034 1.17199411266435 0.228965322617431 0.711705790523051 1 0.0715951 0.0529764 0.0651355 0.0680445 GeneID:6335,Genbank:NM_002977.3,HGNC:HGNC:10597,MIM:603415 sodium voltage-gated channel alpha subunit 9 hsa04742 Taste transduction SCNM1 8.11566869882358 4.60274771635603 11.6285896812911 2.52644515795826 1.33710886343088 0.209852999970118 1 7.61003 7.72804 6.88338 7.61515 GeneID:79005,Genbank:NM_001204856.1,HGNC:HGNC:23136,MIM:608095 sodium channel modifier 1 GO:0006397,GO:0008380,GO:0016607,GO:0019899,GO:0046872 mRNA processing|RNA splicing|nuclear speck|enzyme binding|metal ion binding SCNN1A 441.036835538004 398.420930785352 483.652740290656 1.21392402587208 0.279678132526513 0.123445646135417 1 3.54068 3.69098 4.46674 4.43671 GeneID:6337,Genbank:NM_001159575.1,HGNC:HGNC:10599,MIM:600228 sodium channel epithelial 1 alpha subunit GO:0005737,GO:0005886,GO:0005887,GO:0015280,GO:0016324,GO:0031514,GO:0034220,GO:0034706,GO:0035725,GO:0050699,GO:0050891,GO:0050896,GO:0050909,GO:0055078,GO:0060170,GO:0070062 cytoplasm|plasma membrane|integral component of plasma membrane|ligand-gated sodium channel activity|apical plasma membrane|motile cilium|ion transmembrane transport|sodium channel complex|sodium ion transmembrane transport|WW domain binding|multicellular organismal water homeostasis|response to stimulus|sensory perception of taste|sodium ion homeostasis|ciliary membrane|extracellular exosome hsa04742,hsa04960 Taste transduction|Aldosterone-regulated sodium reabsorption SCNN1D 43.1769478623248 37.4081056821755 48.9457900424741 1.30842738892807 0.387833864362993 0.382216290886372 1 0.400934 0.439444 0.445078 0.507782 GeneID:6339,Genbank:NM_001130413.3,HGNC:HGNC:10601,MIM:601328 sodium channel epithelial 1 delta subunit GO:0005886,GO:0006814,GO:0015280,GO:0015629,GO:0016020,GO:0016021,GO:0034220,GO:0050896,GO:0050909 plasma membrane|sodium ion transport|ligand-gated sodium channel activity|actin cytoskeleton|membrane|integral component of membrane|ion transmembrane transport|response to stimulus|sensory perception of taste SCNN1G 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0211045 0 GeneID:6340,Genbank:NM_001039.3,HGNC:HGNC:10602,MIM:600761 sodium channel epithelial 1 gamma subunit GO:0005216,GO:0005272,GO:0005654,GO:0005886,GO:0005887,GO:0006814,GO:0007588,GO:0009897,GO:0015280,GO:0016324,GO:0034220,GO:0034706,GO:0035725,GO:0050699,GO:0050891,GO:0050896,GO:0050909,GO:0055078,GO:0070062 ion channel activity|sodium channel activity|nucleoplasm|plasma membrane|integral component of plasma membrane|sodium ion transport|excretion|external side of plasma membrane|ligand-gated sodium channel activity|apical plasma membrane|ion transmembrane transport|sodium channel complex|sodium ion transmembrane transport|WW domain binding|multicellular organismal water homeostasis|response to stimulus|sensory perception of taste|sodium ion homeostasis|extracellular exosome hsa04742,hsa04960 Taste transduction|Aldosterone-regulated sodium reabsorption SCO1 1060.9811418397 1086.28566167874 1035.67662200066 0.953410929129018 -0.0688299315000567 0.650153602326361 1 3.97853 4.18541 4.16824 3.67925 GeneID:6341,Genbank:XM_005256751.4,HGNC:HGNC:10603,MIM:603644 SCO1, cytochrome c oxidase assembly protein GO:0005507,GO:0005739,GO:0005743,GO:0006091,GO:0006825,GO:0006878,GO:0008535,GO:0030016,GO:0033617,GO:0072492,GO:1901799 copper ion binding|mitochondrion|mitochondrial inner membrane|generation of precursor metabolites and energy|copper ion transport|cellular copper ion homeostasis|respiratory chain complex IV assembly|myofibril|mitochondrial respiratory chain complex IV assembly|host cell mitochondrial intermembrane space|negative regulation of proteasomal protein catabolic process SCO2 329.201778849601 296.87232337741 361.531234321791 1.21780040055193 0.284277692578191 0.149103792322148 1 11.1986 11.3725 15.9315 14.5886 GeneID:9997,Genbank:NM_001169109.1,HGNC:HGNC:10604,MIM:604272 SCO2, cytochrome c oxidase assembly protein GO:0001654,GO:0005507,GO:0005739,GO:0005743,GO:0005759,GO:0006825,GO:0006878,GO:0008535,GO:0030016,GO:0045454,GO:0055114 eye development|copper ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|copper ion transport|cellular copper ion homeostasis|respiratory chain complex IV assembly|myofibril|cell redox homeostasis|oxidation-reduction process hsa05230 Central carbon metabolism in cancer SCOC 575.134915278096 555.181876478496 595.087954077696 1.07187928729288 0.100142441775303 0.569083222760844 1 12.0099 10.1181 11.313 12.4567 GeneID:60592,Genbank:NM_032547.2,HGNC:HGNC:20335 short coiled-coil protein GO:0000139,GO:0005654,GO:0005768,GO:0005794,GO:0005802,GO:0005829,GO:0016239,GO:0061635 Golgi membrane|nucleoplasm|endosome|Golgi apparatus|trans-Golgi network|cytosol|positive regulation of macroautophagy|regulation of protein complex stability SCP2 905.563618220645 923.746669364026 887.380567077264 0.960631953009586 -0.0579442978862733 0.742540994656455 1 10.5197 9.27659 10.1142 8.81495 GeneID:6342,Genbank:NM_002979.4,HGNC:HGNC:10606,MIM:184755 sterol carrier protein 2 GO:0000062,GO:0005102,GO:0005654,GO:0005739,GO:0005777,GO:0005782,GO:0006694,GO:0006699,GO:0006701,GO:0007031,GO:0008526,GO:0015248,GO:0015485,GO:0015914,GO:0016020,GO:0032385,GO:0032959,GO:0033540,GO:0033814,GO:0036042,GO:0036109,GO:0043231,GO:0043234,GO:0045940,GO:0050632,GO:0070062,GO:0070538,GO:0072659,GO:1901373 fatty-acyl-CoA binding|receptor binding|nucleoplasm|mitochondrion|peroxisome|peroxisomal matrix|steroid biosynthetic process|bile acid biosynthetic process|progesterone biosynthetic process|peroxisome organization|phosphatidylinositol transporter activity|sterol transporter activity|cholesterol binding|phospholipid transport|membrane|positive regulation of intracellular cholesterol transport|inositol trisphosphate biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|propanoyl-CoA C-acyltransferase activity|long-chain fatty acyl-CoA binding|alpha-linolenic acid metabolic process|intracellular membrane-bounded organelle|protein complex|positive regulation of steroid metabolic process|propionyl-CoA C2-trimethyltridecanoyltransferase activity|extracellular exosome|oleic acid binding|protein localization to plasma membrane|lipid hydroperoxide transport hsa00120,hsa01040,hsa03320,hsa04146 Primary bile acid biosynthesis|Biosynthesis of unsaturated fatty acids|PPAR signaling pathway|Peroxisome SCPEP1 1471.24679282653 1336.94821144896 1605.54537420409 1.2009031916532 0.264119855830309 0.0702444833600933 0.92021045003939 24.7432 25.877 30.2232 30.5223 GeneID:59342,Genbank:NM_021626.2,HGNC:HGNC:29507 serine carboxypeptidase 1 GO:0004185,GO:0005829,GO:0042573,GO:0045776,GO:0051603,GO:0070062,GO:0097755 serine-type carboxypeptidase activity|cytosol|retinoic acid metabolic process|negative regulation of blood pressure|proteolysis involved in cellular protein catabolic process|extracellular exosome|positive regulation of blood vessel diameter SCRG1 18.2255099541044 10.2816907859967 26.1693291222121 2.54523596039806 1.34779940998116 0.0466655340768591 0.79332376136203 0.397014 0.25793 0.789047 0.772914 GeneID:11341,Genbank:NM_001329597.1,HGNC:HGNC:17036,MIM:603163 stimulator of chondrogenesis 1 GO:0005615,GO:0005794,GO:0007399,GO:0044306 extracellular space|Golgi apparatus|nervous system development|neuron projection terminus SCRIB 2308.12623889815 2127.64169285914 2488.61078493717 1.16965689913369 0.226085399458169 0.110520106583357 1 16.0462 17.0035 20.0099 18.6929 GeneID:23513,Genbank:NM_015356.4,HGNC:HGNC:30377,MIM:607733 scribbled planar cell polarity protein GO:0001843,GO:0001921,GO:0004385,GO:0005654,GO:0005886,GO:0005911,GO:0005913,GO:0007268,GO:0008283,GO:0014069,GO:0016080,GO:0016323,GO:0016477,GO:0021747,GO:0030027,GO:0030054,GO:0034750,GO:0035089,GO:0035255,GO:0035748,GO:0039502,GO:0039563,GO:0039564,GO:0042060,GO:0043065,GO:0043113,GO:0043615,GO:0044291,GO:0045197,GO:0045296,GO:0045930,GO:0048488,GO:0050918,GO:0060088,GO:0060561,GO:0060603,GO:0070062,GO:0071896,GO:0090630,GO:0097120,GO:0098609,GO:0098793,GO:0098887,GO:0098968 neural tube closure|positive regulation of receptor recycling|guanylate kinase activity|nucleoplasm|plasma membrane|cell-cell junction|cell-cell adherens junction|chemical synaptic transmission|cell proliferation|postsynaptic density|synaptic vesicle targeting|basolateral plasma membrane|cell migration|cochlear nucleus development|lamellipodium|cell junction|Scrib-APC-beta-catenin complex|establishment of apical/basal cell polarity|ionotropic glutamate receptor binding|myelin sheath abaxonal region|suppression by virus of host type I interferon-mediated signaling pathway|suppression by virus of host STAT1 activity|suppression by virus of host STAT2 activity|wound healing|positive regulation of apoptotic process|receptor clustering|astrocyte cell migration|cell-cell contact zone|establishment or maintenance of epithelial cell apical/basal polarity|cadherin binding|negative regulation of mitotic cell cycle|synaptic vesicle endocytosis|positive chemotaxis|auditory receptor cell stereocilium organization|apoptotic process involved in morphogenesis|mammary gland duct morphogenesis|extracellular exosome|protein localization to adherens junction|activation of GTPase activity|receptor localization to synapse|cell-cell adhesion|presynapse|neurotransmitter receptor transport, endosome to postsynaptic membrane|neurotransmitter receptor transport postsynaptic membrane to endosome hsa04390,hsa04530,hsa05165,hsa05203 Hippo signaling pathway|Tight junction|Human papillomavirus infection|Viral carcinogenesis SCRN1 8842.78260615198 8264.95744481078 9420.60776749319 1.1398253203842 0.188812746561197 0.146902001202778 1 51.3885 51.8814 63.7789 55.3955 GeneID:9805,Genbank:NM_001145514.1,HGNC:HGNC:22192,MIM:614965 secernin 1 GO:0005634,GO:0005737,GO:0006887,GO:0016805,GO:0031965 nucleus|cytoplasm|exocytosis|dipeptidase activity|nuclear membrane SCRN2 318.819642713389 329.908004061546 307.731281365232 0.932779070458148 -0.100392676937493 0.615789467522494 1 4.12889 3.89674 3.46051 3.87549 GeneID:90507,Genbank:NM_138355.3,HGNC:HGNC:30381,MIM:614966 secernin 2 GO:0006887,GO:0016805,GO:0070062 exocytosis|dipeptidase activity|extracellular exosome SCRN3 211.282602165076 234.989056561835 187.576147768317 0.798233545479844 -0.325117186020023 0.287703518542529 1 1.86441 1.5017 1.7038 1.18857 GeneID:79634,Genbank:NM_024583.4,HGNC:HGNC:30382,MIM:614967 secernin 3 GO:0006887,GO:0016805 exocytosis|dipeptidase activity SCRT1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0155595 0 0 0 GeneID:83482,Genbank:NM_031309.5,HGNC:HGNC:15950,MIM:605858 scratch family transcriptional repressor 1 GO:0000122,GO:0000977,GO:0001227,GO:0003700,GO:0006351,GO:0006355,GO:0016604,GO:0043565,GO:0046872,GO:2001222 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear body|sequence-specific DNA binding|metal ion binding|regulation of neuron migration SCT 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0586624 0 0 GeneID:6343,Genbank:XM_017018109.1,HGNC:HGNC:10607,MIM:182099 secretin hsa04080,hsa04972 Neuroactive ligand-receptor interaction|Pancreatic secretion SCUBE2 2.2365983412757 1.56626675524197 2.90692992730943 1.85596094508202 0.892166352206154 0.765322895163955 1 0.00482632 0.00449652 0.00460098 0.00856478 GeneID:57758,Genbank:NM_001330199.1,HGNC:HGNC:30425,MIM:611747 signal peptide, CUB domain and EGF like domain containing 2 GO:0005509,GO:0005576,GO:0005615,GO:0007165,GO:0007275,GO:0008289,GO:0009986,GO:0030154 calcium ion binding|extracellular region|extracellular space|signal transduction|multicellular organism development|lipid binding|cell surface|cell differentiation SCUBE3 2878.90709094426 2593.00724961135 3164.80693227717 1.22051603702671 0.287491251601577 0.0365177906193693 0.739899327172153 11.325 11.5901 15.5488 13.0711 GeneID:222663,Genbank:XM_005248943.1,HGNC:HGNC:13655,MIM:614708 signal peptide, CUB domain and EGF like domain containing 3 GO:0005509,GO:0005615,GO:0005886,GO:0007165,GO:0009986,GO:0022617,GO:0030154,GO:0045880,GO:0051260,GO:0051291 calcium ion binding|extracellular space|plasma membrane|signal transduction|cell surface|extracellular matrix disassembly|cell differentiation|positive regulation of smoothened signaling pathway|protein homooligomerization|protein heterooligomerization SCX 68.5377036136201 58.567419860604 78.5079873666362 1.34047201590052 0.422741101496565 0.243163438606396 1 0.643928 0.76252 1.16662 0.9621 GeneID:642658,Genbank:XM_006716616.2,HGNC:HGNC:32322,MIM:609067 scleraxis bHLH transcription factor GO:0000980,GO:0001205,GO:0001707,GO:0001894,GO:0001958,GO:0002062,GO:0003179,GO:0003188,GO:0003677,GO:0005634,GO:0005667,GO:0006351,GO:0008284,GO:0010628,GO:0030154,GO:0030199,GO:0030509,GO:0032967,GO:0035914,GO:0035989,GO:0035990,GO:0035992,GO:0035993,GO:0043066,GO:0043425,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0046982,GO:0048706,GO:0060008,GO:0060325,GO:0061035,GO:0061036,GO:0061056,GO:0070888,GO:0071260,GO:0071560,GO:2000543 RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|mesoderm formation|tissue homeostasis|endochondral ossification|chondrocyte differentiation|heart valve morphogenesis|heart valve formation|DNA binding|nucleus|transcription factor complex|transcription, DNA-templated|positive regulation of cell proliferation|positive regulation of gene expression|cell differentiation|collagen fibril organization|BMP signaling pathway|positive regulation of collagen biosynthetic process|skeletal muscle cell differentiation|tendon development|tendon cell differentiation|tendon formation|deltoid tuberosity development|negative regulation of apoptotic process|bHLH transcription factor binding|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|embryonic skeletal system development|Sertoli cell differentiation|face morphogenesis|regulation of cartilage development|positive regulation of cartilage development|sclerotome development|E-box binding|cellular response to mechanical stimulus|cellular response to transforming growth factor beta stimulus|positive regulation of gastrulation SCYL1 1983.56031785069 1980.22930442191 1986.89133127947 1.00336427041186 0.00484547006615408 1 1 19.1934 21.0142 20.4485 21.2485 GeneID:57410,Genbank:NM_020680.3,HGNC:HGNC:14372,MIM:607982 SCY1 like pseudokinase 1 GO:0003677,GO:0004713,GO:0005524,GO:0005634,GO:0005737,GO:0005793,GO:0005794,GO:0005801,GO:0005815,GO:0005829,GO:0006351,GO:0006355,GO:0006890,GO:0016020,GO:0030126,GO:0045296 DNA binding|protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|microtubule organizing center|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|retrograde vesicle-mediated transport, Golgi to ER|membrane|COPI vesicle coat|cadherin binding SCYL2 313.874490945102 321.903165495958 305.845816394247 0.950117455114271 -0.0738222220369457 0.794915194757918 1 2.22698 1.86278 2.32307 1.54472 GeneID:55681,Genbank:NM_001330256.1,HGNC:HGNC:19286,MIM:616365 SCY1 like pseudokinase 2 GO:0002092,GO:0004672,GO:0005102,GO:0005524,GO:0005794,GO:0008333,GO:0010008,GO:0030136,GO:0048471,GO:0090090,GO:2000286,GO:2000370 positive regulation of receptor internalization|protein kinase activity|receptor binding|ATP binding|Golgi apparatus|endosome to lysosome transport|endosome membrane|clathrin-coated vesicle|perinuclear region of cytoplasm|negative regulation of canonical Wnt signaling pathway|receptor internalization involved in canonical Wnt signaling pathway|positive regulation of clathrin-dependent endocytosis SCYL3 142.665975294015 153.495159014568 131.836791573463 0.858898693742846 -0.219440117951831 0.402203936322341 1 1.17229 1.162 1.44702 0.787141 GeneID:57147,Genbank:NM_020423.6,HGNC:HGNC:19285,MIM:608192 SCY1 like pseudokinase 3 GO:0005524,GO:0005737,GO:0005794,GO:0006468,GO:0016477,GO:0030027 ATP binding|cytoplasm|Golgi apparatus|protein phosphorylation|cell migration|lamellipodium SDAD1 562.296504531304 616.180036038671 508.412973023937 0.825104585167101 -0.277351096815056 0.178565717324778 1 5.81734 4.87728 4.84722 3.99236 GeneID:55153,Genbank:NM_001288983.1,HGNC:HGNC:25537 SDA1 domain containing 1 GO:0000055,GO:0005634,GO:0005730,GO:0030036,GO:0042273 ribosomal large subunit export from nucleus|nucleus|nucleolus|actin cytoskeleton organization|ribosomal large subunit biogenesis SDC1 5978.12607006867 5289.57446951571 6666.67767062164 1.26034290830809 0.333816308971185 0.0124018476971913 0.456616075214288 57.7148 61.5533 79.2028 73.3428 GeneID:6382,Genbank:NM_001006946.1,HGNC:HGNC:10658,MIM:186355 syndecan 1 hsa04512,hsa04514,hsa05144,hsa05205,hsa05418 ECM-receptor interaction|Cell adhesion molecules (CAMs)|Malaria|Proteoglycans in cancer|Fluid shear stress and atherosclerosis SDC2 4140.08817018449 4470.2441073822 3809.93223298678 0.852287289344004 -0.230588278228463 0.0838076503839991 0.963076417285947 47.7445 51.07 40.7261 43.8547 GeneID:6383,Genbank:XM_024447228.1,HGNC:HGNC:10659,MIM:142460 syndecan 2 GO:0001523,GO:0005788,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0008218,GO:0009986,GO:0016021,GO:0016477,GO:0030165,GO:0030203,GO:0031012,GO:0042802,GO:0043202,GO:0043687,GO:0044267,GO:0048013,GO:0048813,GO:0048814,GO:0050900 retinoid metabolic process|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|bioluminescence|cell surface|integral component of membrane|cell migration|PDZ domain binding|glycosaminoglycan metabolic process|extracellular matrix|identical protein binding|lysosomal lumen|post-translational protein modification|cellular protein metabolic process|ephrin receptor signaling pathway|dendrite morphogenesis|regulation of dendrite morphogenesis|leukocyte migration hsa04514,hsa05144,hsa05205,hsa05418 Cell adhesion molecules (CAMs)|Malaria|Proteoglycans in cancer|Fluid shear stress and atherosclerosis SDC3 1877.40069384168 1746.57314089443 2008.22824678893 1.14981056319262 0.201396189817445 0.157198727646519 1 11.3275 11.2521 13.033 13.4086 GeneID:9672,Genbank:XM_011542463.1,HGNC:HGNC:10660,MIM:186357 syndecan 3 GO:0001523,GO:0005796,GO:0005886,GO:0006024,GO:0006027,GO:0009986,GO:0016020,GO:0016021,GO:0016477,GO:0030203,GO:0031012,GO:0042802,GO:0043202,GO:0050900 retinoid metabolic process|Golgi lumen|plasma membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cell surface|membrane|integral component of membrane|cell migration|glycosaminoglycan metabolic process|extracellular matrix|identical protein binding|lysosomal lumen|leukocyte migration hsa04514 Cell adhesion molecules (CAMs) SDC4 2250.21257261077 2111.23596287367 2389.18918234787 1.13165426525601 0.178433263835728 0.197460302755223 1 37.3945 36.8113 43.0165 42.3891 GeneID:6385,Genbank:NM_002999.3,HGNC:HGNC:10661,MIM:600017 syndecan 4 GO:0001523,GO:0001657,GO:0001843,GO:0001968,GO:0005080,GO:0005796,GO:0005886,GO:0005887,GO:0005925,GO:0006024,GO:0006027,GO:0009986,GO:0010762,GO:0016477,GO:0030203,GO:0042060,GO:0042130,GO:0042802,GO:0043034,GO:0043202,GO:0045121,GO:0045860,GO:0050900,GO:0051496,GO:0051894,GO:0060122,GO:0070053,GO:0070062,GO:1903543,GO:1903553 retinoid metabolic process|ureteric bud development|neural tube closure|fibronectin binding|protein kinase C binding|Golgi lumen|plasma membrane|integral component of plasma membrane|focal adhesion|glycosaminoglycan biosynthetic process|glycosaminoglycan catabolic process|cell surface|regulation of fibroblast migration|cell migration|glycosaminoglycan metabolic process|wound healing|negative regulation of T cell proliferation|identical protein binding|costamere|lysosomal lumen|membrane raft|positive regulation of protein kinase activity|leukocyte migration|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|inner ear receptor cell stereocilium organization|thrombospondin receptor activity|extracellular exosome|positive regulation of exosomal secretion|positive regulation of extracellular exosome assembly hsa04512,hsa04514,hsa05205,hsa05418 ECM-receptor interaction|Cell adhesion molecules (CAMs)|Proteoglycans in cancer|Fluid shear stress and atherosclerosis SDCBP 2495.34107804978 2486.50481690487 2504.17733919468 1.00710737504696 0.010217507763224 0.907781471775766 1 18.278 15.5286 18.3569 15.991 GeneID:6386,Genbank:NM_001348341.1,HGNC:HGNC:10662,MIM:602217 syndecan binding protein SDCBP2 14.2245841333378 14.3943671003953 14.0548011662804 0.976409804491812 -0.0344413130613128 1 1 0.302627 0.219274 0.257054 0.283286 GeneID:27111,Genbank:NM_080489.4,HGNC:HGNC:15756,MIM:617358 syndecan binding protein 2 GO:0005546,GO:0005730,GO:0005737,GO:0005886,GO:0007399,GO:0008022,GO:0008283,GO:0016607,GO:0035556,GO:0042802,GO:0042803,GO:0046907,GO:0046982,GO:0070062 phosphatidylinositol-4,5-bisphosphate binding|nucleolus|cytoplasm|plasma membrane|nervous system development|protein C-terminus binding|cell proliferation|nuclear speck|intracellular signal transduction|identical protein binding|protein homodimerization activity|intracellular transport|protein heterodimerization activity|extracellular exosome SDCCAG3 1744.6033520457 1798.32758740232 1690.87911668908 0.940250891180264 -0.088882326218709 0.527272765751391 1 24.6866 25.3291 24.3396 23.034 GeneID:10807,Genbank:NM_001039708.1,HGNC:HGNC:10667 serologically defined colon cancer antigen 3 GO:0005768,GO:0005769,GO:0007049,GO:0015031,GO:0030496,GO:0032465,GO:0051301,GO:0055037,GO:1990126 endosome|early endosome|cell cycle|protein transport|midbody|regulation of cytokinesis|cell division|recycling endosome|retrograde transport, endosome to plasma membrane SDCCAG8 211.064128298162 216.635900626204 205.49235597012 0.948560951237204 -0.0761876156919181 0.770259975453809 1 0.455575 0.408144 0.450137 0.352972 GeneID:10806,Genbank:XM_011544026.3,HGNC:HGNC:10671,MIM:613524 serologically defined colon cancer antigen 8 GO:0000086,GO:0001764,GO:0005813,GO:0005814,GO:0005829,GO:0005911,GO:0007098,GO:0010389,GO:0030010,GO:0034451,GO:0035148,GO:0097711 G2/M transition of mitotic cell cycle|neuron migration|centrosome|centriole|cytosol|cell-cell junction|centrosome cycle|regulation of G2/M transition of mitotic cell cycle|establishment of cell polarity|centriolar satellite|tube formation|ciliary basal body-plasma membrane docking SDE2 717.820806188676 808.026242920607 627.615369456745 0.776726467680347 -0.364521466908635 0.0240976364420319 0.621959897532696 9.67854 10.0222 8.22876 7.09966 GeneID:163859,Genbank:NM_152608.3,HGNC:HGNC:26643 SDE2 telomere maintenance homolog GO:0003677,GO:0005634,GO:0006260,GO:0007049,GO:0051301 DNA binding|nucleus|DNA replication|cell cycle|cell division SDF2 1443.95511682296 1370.59944204975 1517.31079159616 1.10704174031109 0.146709619052211 0.320651030911537 1 26.5734 27.8967 30.7964 32.1875 GeneID:6388,Genbank:NM_006923.3,HGNC:HGNC:10675,MIM:602934 stromal cell derived factor 2 GO:0004169,GO:0005615,GO:0005789,GO:0006486,GO:0071712 dolichyl-phosphate-mannose-protein mannosyltransferase activity|extracellular space|endoplasmic reticulum membrane|protein glycosylation|ER-associated misfolded protein catabolic process SDF2L1 316.944720821877 304.86735328789 329.022088355864 1.07923031051857 0.110002772506257 0.696211474691475 1 22.6086 24.5153 23.4054 28.8902 GeneID:23753,Genbank:NM_022044.2,HGNC:HGNC:10676,MIM:607551 stromal cell derived factor 2 like 1 GO:0004169,GO:0005788,GO:0005789,GO:0034663,GO:0042981,GO:0051087,GO:0051117,GO:0051787,GO:0071712 dolichyl-phosphate-mannose-protein mannosyltransferase activity|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endoplasmic reticulum chaperone complex|regulation of apoptotic process|chaperone binding|ATPase binding|misfolded protein binding|ER-associated misfolded protein catabolic process SDF4 6238.04532603289 5801.43999152493 6674.65066054085 1.15051619430548 0.202281290628296 0.131298082447018 1 41.0656 42.8686 50.5173 50.5304 GeneID:51150,Genbank:NM_016176.3,HGNC:HGNC:24188,MIM:614282 stromal cell derived factor 4 GO:0005509,GO:0005737,GO:0005770,GO:0005794,GO:0005796,GO:0005886,GO:0009650,GO:0016020,GO:0017156,GO:0021549,GO:0032059,GO:0042802,GO:0045444,GO:0045471,GO:0070062,GO:0070625 calcium ion binding|cytoplasm|late endosome|Golgi apparatus|Golgi lumen|plasma membrane|UV protection|membrane|calcium ion regulated exocytosis|cerebellum development|bleb|identical protein binding|fat cell differentiation|response to ethanol|extracellular exosome|zymogen granule exocytosis SDHA 4482.94269285823 4324.8596481377 4641.02573757876 1.07310435832922 0.101790383571638 0.453256099988897 1 24.0681 25.2358 25.7008 27.9067 GeneID:6389,Genbank:NM_004168.3,HGNC:HGNC:10680,MIM:600857 succinate dehydrogenase complex flavoprotein subunit A hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease SDHAF1 354.727800808106 348.434664786556 361.020936829656 1.03612233028195 0.0511943455652932 0.809839380239914 1 16.5053 17.4041 16.893 18.9449 GeneID:644096,Genbank:NM_001042631.2,HGNC:HGNC:33867,MIM:612848 succinate dehydrogenase complex assembly factor 1 GO:0005739,GO:0005759,GO:0034553 mitochondrion|mitochondrial matrix|mitochondrial respiratory chain complex II assembly SDHAF2 726.463723184861 764.795115344736 688.132331024986 0.899760363551493 -0.152387280501195 0.345680172648146 1 25.9273 26.1552 23.0557 25.2785 GeneID:54949,Genbank:NM_017841.2,HGNC:HGNC:26034,MIM:613019 succinate dehydrogenase complex assembly factor 2 SDHAF3 221.536725799884 232.750421961004 210.323029638764 0.903641883295929 -0.146176954498349 0.529134589679885 1 5.27628 4.31713 4.43378 4.51166 GeneID:57001,Genbank:NM_020186.2,HGNC:HGNC:21752,MIM:615773 succinate dehydrogenase complex assembly factor 3 GO:0005758,GO:0005759,GO:0006105,GO:0006111,GO:0006979,GO:0034553 mitochondrial intermembrane space|mitochondrial matrix|succinate metabolic process|regulation of gluconeogenesis|response to oxidative stress|mitochondrial respiratory chain complex II assembly SDHAF4 142.960622054194 143.463408257104 142.457835851283 0.992990739464252 -0.0101478315056134 0.980872206908178 1 6.34677 6.69857 5.52932 7.83472 GeneID:135154,Genbank:NM_145267.2,HGNC:HGNC:20957 succinate dehydrogenase complex assembly factor 4 GO:0003407,GO:0005749,GO:0005759,GO:0008177,GO:0034553,GO:0045087,GO:0045333 neural retina development|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|mitochondrial matrix|succinate dehydrogenase (ubiquinone) activity|mitochondrial respiratory chain complex II assembly|innate immune response|cellular respiration SDHB 3138.52443192673 3066.11993024721 3210.92893360625 1.0472287472941 0.066576606109873 0.63581468154867 1 85.5162 93.7564 90.8409 100.353 GeneID:6390,Genbank:NM_003000.2,HGNC:HGNC:10681,MIM:185470 succinate dehydrogenase complex iron sulfur subunit B hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease SDHC 2034.78029419959 2224.86386754202 1844.69672085716 0.829127906551487 -0.270333416672491 0.257567646828812 1 33.8859 35.4945 24.8391 33.4471 GeneID:6391,Genbank:NM_003001.3,HGNC:HGNC:10682,MIM:602413 succinate dehydrogenase complex subunit C hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease SDHD 1439.39441992728 1450.61229973518 1428.17654011939 0.98453359342128 -0.0224876615025991 0.893669466196595 1 44.1293 44.2288 44.155 43.2864 GeneID:6392,Genbank:NM_001276506.1,HGNC:HGNC:10683,MIM:602690 succinate dehydrogenase complex subunit D hsa00020,hsa00190,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Citrate cycle (TCA cycle)|Oxidative phosphorylation|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease SDK1 1322.20114112199 1171.54725996336 1472.85502228061 1.25718788529852 0.330200275003068 0.0252668294942534 0.631315976879816 2.72295 2.76858 3.72991 3.29879 GeneID:221935,Genbank:NM_152744.3,HGNC:HGNC:19307,MIM:607216 sidekick cell adhesion molecule 1 GO:0005886,GO:0007156,GO:0007416,GO:0010842,GO:0016021,GO:0030054,GO:0042802,GO:0045202,GO:0045216,GO:0048148,GO:0060998,GO:0070062 plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|synapse assembly|retina layer formation|integral component of membrane|cell junction|identical protein binding|synapse|cell-cell junction organization|behavioral response to cocaine|regulation of dendritic spine development|extracellular exosome SDK2 4.44529117182232 6.46698077481559 2.42360156882906 0.374765544110987 -1.41593977696303 0.401134885366267 1 0.00632837 0.0303386 0.00586581 0.00274904 GeneID:54549,Genbank:XM_011524915.2,HGNC:HGNC:19308,MIM:607217 sidekick cell adhesion molecule 2 SDR39U1 607.398010559469 605.160367823894 609.635653295044 1.00739520581502 0.0106297703519816 0.973931647919555 1 10.7254 11.0323 11.2051 11.9075 GeneID:56948,Genbank:XM_011536975.2,HGNC:HGNC:20275,MIM:616162 short chain dehydrogenase/reductase family 39U member 1 GO:0005634,GO:0016491 nucleus|oxidoreductase activity SDR9C7 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0687262 GeneID:121214,Genbank:NM_148897.2,HGNC:HGNC:29958,MIM:609769 short chain dehydrogenase/reductase family 9C member 7 GO:0004745,GO:0005730,GO:0005829,GO:0055114 retinol dehydrogenase activity|nucleolus|cytosol|oxidation-reduction process SDS 1.45683648539321 0.490071401957362 2.42360156882906 4.94540501475725 2.30608867848779 0.553970604158029 1 0 0.0278445 0.0296044 0.0551545 GeneID:10993,Genbank:NM_006843.2,HGNC:HGNC:10691,MIM:182128 serine dehydratase GO:0003941,GO:0004794,GO:0005739,GO:0005829,GO:0006094,GO:0006565,GO:0030170,GO:0042803,GO:0042866 L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|mitochondrion|cytosol|gluconeogenesis|L-serine catabolic process|pyridoxal phosphate binding|protein homodimerization activity|pyruvate biosynthetic process hsa00260,hsa00270,hsa00290 Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Valine, leucine and isoleucine biosynthesis SDSL 177.120188437343 165.256872661545 188.983504213142 1.14357425001132 0.193550040122558 0.430034254886373 1 2.53985 2.71103 2.78958 3.24158 GeneID:113675,Genbank:XM_011537846.2,HGNC:HGNC:30404 serine dehydratase like GO:0003941,GO:0004794,GO:0005739,GO:0006520,GO:0030170,GO:0042802,GO:0070062 L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|mitochondrion|cellular amino acid metabolic process|pyridoxal phosphate binding|identical protein binding|extracellular exosome hsa00260,hsa00270,hsa00290 Glycine, serine and threonine metabolism|Cysteine and methionine metabolism|Valine, leucine and isoleucine biosynthesis SEC11A 3740.57632098066 3735.78234168157 3745.37030027975 1.00256651959918 0.0036979616797903 0.975408116426544 1 76.5133 74.5354 71.6012 82.4881 GeneID:23478,Genbank:NM_001271921.1,HGNC:HGNC:17718 SEC11 homolog A, signal peptidase complex subunit GO:0005787,GO:0006465,GO:0008233,GO:0008236,GO:0016021,GO:0031090 signal peptidase complex|signal peptide processing|peptidase activity|serine-type peptidase activity|integral component of membrane|organelle membrane hsa03060 Protein export SEC11C 188.470151159273 197.648594464561 179.291707853986 0.907123616738564 -0.140628929906917 0.567644466095531 1 6.05504 5.29711 4.82654 5.21111 GeneID:90701,Genbank:NM_033280.3,HGNC:HGNC:23400 SEC11 homolog C, signal peptidase complex subunit GO:0005787,GO:0005789,GO:0006465,GO:0008233,GO:0008236,GO:0016021,GO:0031090 signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|peptidase activity|serine-type peptidase activity|integral component of membrane|organelle membrane hsa03060 Protein export SEC13 4905.53706684301 4383.35063275915 5427.72350092687 1.23825902960228 0.308313141396255 0.0213539380890948 0.598036670329243 45.6544 48.5806 60.5678 62.1979 GeneID:6396,Genbank:NM_183352.2,HGNC:HGNC:10697,MIM:600152 SEC13 homolog, nuclear pore and COPII coat complex component GO:0000139,GO:0002474,GO:0005198,GO:0005635,GO:0005654,GO:0005765,GO:0005789,GO:0005829,GO:0006886,GO:0007062,GO:0012507,GO:0019886,GO:0030127,GO:0031080,GO:0032008,GO:0042802,GO:0043231,GO:0048208,GO:0051028,GO:0061700,GO:0070062,GO:0090110,GO:1904263 Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|structural molecule activity|nuclear envelope|nucleoplasm|lysosomal membrane|endoplasmic reticulum membrane|cytosol|intracellular protein transport|sister chromatid cohesion|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|nuclear pore outer ring|positive regulation of TOR signaling|identical protein binding|intracellular membrane-bounded organelle|COPII vesicle coating|mRNA transport|GATOR2 complex|extracellular exosome|cargo loading into COPII-coated vesicle|positive regulation of TORC1 signaling hsa03013,hsa04141,hsa04150 RNA transport|Protein processing in endoplasmic reticulum|mTOR signaling pathway SEC14L1 8248.12342592497 8441.85563760888 8054.39121424106 0.95410198420811 -0.0677846103677764 0.595418557551257 1 56.8146 58.7329 60.162 52.0778 GeneID:6397,Genbank:NM_001204408.1,HGNC:HGNC:10698,MIM:601504 SEC14 like lipid binding 1 GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0015871,GO:0039536,GO:0039552,GO:0045087,GO:0098772 nucleoplasm|cytoplasm|Golgi apparatus|cytosol|choline transport|negative regulation of RIG-I signaling pathway|RIG-I binding|innate immune response|molecular function regulator SEC14L2 830.804170060815 844.560067003345 817.048273118285 0.96742470434024 -0.0477787156997373 0.762524255731112 1 6.43614 6.45078 6.20875 6.4958 GeneID:23541,Genbank:NM_012429.4,HGNC:HGNC:10699,MIM:607558 SEC14 like lipid binding 2 GO:0005543,GO:0005634,GO:0005737,GO:0005829,GO:0006351,GO:0008431,GO:0045540,GO:0045893,GO:0070062 phospholipid binding|nucleus|cytoplasm|cytosol|transcription, DNA-templated|vitamin E binding|regulation of cholesterol biosynthetic process|positive regulation of transcription, DNA-templated|extracellular exosome SEC14L5 1.96961606661295 1.51824048055703 2.42099165266886 1.5946035451384 0.673197781633739 0.891335562943805 1 0.00709128 0.00634993 0 0.00621689 GeneID:9717,Genbank:XM_024450497.1,HGNC:HGNC:29032 SEC14 like lipid binding 5 SEC16A 2818.96753553082 2684.10066144391 2953.83440961773 1.10049315662726 0.138150173915873 0.315588093315672 1 9.78867 9.75021 11.1976 10.5067 GeneID:9919,Genbank:XM_011519260.2,HGNC:HGNC:29006,MIM:612854 SEC16 homolog A, endoplasmic reticulum export factor GO:0000139,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0007029,GO:0015031,GO:0021762,GO:0048208 Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|endoplasmic reticulum organization|protein transport|substantia nigra development|COPII vesicle coating SEC22A 367.403637448479 380.076566503974 354.730708392984 0.933313810045889 -0.0995658518843819 0.617102269729966 1 2.89923 2.64582 2.62125 2.67762 GeneID:26984,Genbank:NM_012430.4,HGNC:HGNC:20260,MIM:612442 SEC22 homolog A, vesicle trafficking protein GO:0000149,GO:0005215,GO:0005484,GO:0005789,GO:0006888,GO:0015031,GO:0016021,GO:0031201,GO:0048280 SNARE binding|transporter activity|SNAP receptor activity|endoplasmic reticulum membrane|ER to Golgi vesicle-mediated transport|protein transport|integral component of membrane|SNARE complex|vesicle fusion with Golgi apparatus SEC22B 7591.38397520505 7661.85443214494 7520.91351826515 0.981604856222733 -0.0267857085280229 0.841176469248336 1 71.3287 75.278 75.2476 72.3331 GeneID:9554,Genbank:NM_004892.5,HGNC:HGNC:10700,MIM:604029 SEC22 homolog B, vesicle trafficking protein (gene/pseudogene) GO:0000139,GO:0000149,GO:0005484,GO:0005789,GO:0005793,GO:0006888,GO:0012507,GO:0015031,GO:0016021,GO:0016192,GO:0019905,GO:0031201,GO:0033116,GO:0042470,GO:0045732,GO:0048280,GO:1902902 Golgi membrane|SNARE binding|SNAP receptor activity|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|ER to Golgi vesicle-mediated transport|ER to Golgi transport vesicle membrane|protein transport|integral component of membrane|vesicle-mediated transport|syntaxin binding|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|melanosome|positive regulation of protein catabolic process|vesicle fusion with Golgi apparatus|negative regulation of autophagosome assembly hsa04130,hsa04145,hsa05134 SNARE interactions in vesicular transport|Phagosome|Legionellosis SEC22C 2244.04769112759 2117.73338661466 2370.36199564052 1.11929198010601 0.162586428900356 0.248961410795606 1 7.04934 7.69159 8.72842 7.80014 GeneID:9117,Genbank:NM_001201572.1,HGNC:HGNC:16828,MIM:604028 SEC22 homolog C, vesicle trafficking protein GO:0000149,GO:0005484,GO:0005783,GO:0005789,GO:0006888,GO:0015031,GO:0016021,GO:0031201,GO:0048280 SNARE binding|SNAP receptor activity|endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi vesicle-mediated transport|protein transport|integral component of membrane|SNARE complex|vesicle fusion with Golgi apparatus SEC23A 2127.33283190406 2562.82946009467 1691.83620371346 0.660143887861723 -0.599147579992488 0.000190133909884589 0.0350021229966849 23.38 20.164 14.4252 14.1179 GeneID:10484,Genbank:NM_006364.3,HGNC:HGNC:10701,MIM:610511 Sec23 homolog A, coat complex II component GO:0000139,GO:0002474,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0019898,GO:0030127,GO:0048208,GO:0048471,GO:0070971,GO:0090110 Golgi membrane|antigen processing and presentation of peptide antigen via MHC class I|endoplasmic reticulum membrane|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|extrinsic component of membrane|COPII vesicle coat|COPII vesicle coating|perinuclear region of cytoplasm|endoplasmic reticulum exit site|cargo loading into COPII-coated vesicle hsa04141 Protein processing in endoplasmic reticulum SEC23B 1917.07240838817 1974.62374558886 1859.52107118749 0.941709059936862 -0.0866466853872988 0.546479799069758 1 18.6924 18.0079 17.853 16.861 GeneID:10483,Genbank:NM_032985.5,HGNC:HGNC:10702,MIM:610512 Sec23 homolog B, coat complex II component GO:0000139,GO:0005783,GO:0005789,GO:0005829,GO:0006886,GO:0008270,GO:0012505,GO:0030127,GO:0048471,GO:0090114 Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|intracellular protein transport|zinc ion binding|endomembrane system|COPII vesicle coat|perinuclear region of cytoplasm|COPII-coated vesicle budding hsa04141 Protein processing in endoplasmic reticulum SEC23IP 1126.02868784375 1227.44075774841 1024.61661793908 0.834758509908552 -0.260569199033489 0.209031158840843 1 6.57572 5.79896 6.04972 4.37816 GeneID:11196,Genbank:NM_007190.3,HGNC:HGNC:17018,MIM:617852 SEC23 interacting protein GO:0000139,GO:0003723,GO:0004620,GO:0005737,GO:0005783,GO:0005793,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0007030,GO:0012507,GO:0030134,GO:0043231,GO:0046872,GO:0048208 Golgi membrane|RNA binding|phospholipase activity|cytoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|Golgi organization|ER to Golgi transport vesicle membrane|COPII-coated ER to Golgi transport vesicle|intracellular membrane-bounded organelle|metal ion binding|COPII vesicle coating SEC24A 583.565648560123 599.085371899956 568.04592522029 0.948188608609777 -0.0767540340324015 0.783389023693648 1 3.31789 2.77739 3.31997 2.42485 GeneID:10802,Genbank:XM_017008961.2,HGNC:HGNC:10703,MIM:607183 SEC24 homolog A, COPII coat complex component hsa04141 Protein processing in endoplasmic reticulum SEC24B 389.341419287138 399.649996616945 379.032841957332 0.948411973391374 -0.0764142183988229 0.776153045960861 1 2.98889 2.58529 3.12015 2.0942 GeneID:10427,Genbank:NM_001300813.2,HGNC:HGNC:10704,MIM:607184 SEC24 homolog B, COPII coat complex component GO:0000139,GO:0001843,GO:0002474,GO:0003151,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0021747,GO:0030127,GO:0035909,GO:0048208,GO:0060088,GO:0060463,GO:0060982,GO:0061156,GO:0090110,GO:0090178,GO:1901301 Golgi membrane|neural tube closure|antigen processing and presentation of peptide antigen via MHC class I|outflow tract morphogenesis|endoplasmic reticulum membrane|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|cochlear nucleus development|COPII vesicle coat|aorta morphogenesis|COPII vesicle coating|auditory receptor cell stereocilium organization|lung lobe morphogenesis|coronary artery morphogenesis|pulmonary artery morphogenesis|cargo loading into COPII-coated vesicle|regulation of establishment of planar polarity involved in neural tube closure|regulation of cargo loading into COPII-coated vesicle hsa04141 Protein processing in endoplasmic reticulum SEC24C 5056.84396170909 4629.18011209469 5484.50781132349 1.18476872329812 0.244605460545031 0.0685357332277032 0.918202374283561 31.3139 33.0324 39.6099 38.4476 GeneID:9632,Genbank:XM_011540381.3,HGNC:HGNC:10705,MIM:607185 SEC24 homolog C, COPII coat complex component GO:0000139,GO:0000149,GO:0001701,GO:0002474,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0030127,GO:0048208,GO:0090110 Golgi membrane|SNARE binding|in utero embryonic development|antigen processing and presentation of peptide antigen via MHC class I|endoplasmic reticulum membrane|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|COPII vesicle coating|cargo loading into COPII-coated vesicle hsa04141 Protein processing in endoplasmic reticulum SEC24D 986.893271951321 965.652678558934 1008.13386534371 1.04399220105532 0.0621109345698284 0.704229993057024 1 6.69314 6.37275 7.72493 6.06609 GeneID:9871,Genbank:XM_024454293.1,HGNC:HGNC:10706,MIM:607186 SEC24 homolog D, COPII coat complex component GO:0000139,GO:0000149,GO:0001701,GO:0002474,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0008270,GO:0012507,GO:0019886,GO:0030127,GO:0048208,GO:0090110 Golgi membrane|SNARE binding|in utero embryonic development|antigen processing and presentation of peptide antigen via MHC class I|endoplasmic reticulum membrane|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|zinc ion binding|ER to Golgi transport vesicle membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|COPII vesicle coating|cargo loading into COPII-coated vesicle hsa04141 Protein processing in endoplasmic reticulum SEC31A 2786.42311257847 2797.72449810885 2775.12172704809 0.9919210161415 -0.0117028474179444 0.955179828107581 1 19.1491 17.8522 20.202 17.1743 GeneID:22872,Genbank:NM_001318120.1,HGNC:HGNC:17052,MIM:610257 SEC31 homolog A, COPII coat complex component GO:0005789,GO:0015031,GO:0016192,GO:0030127,GO:0030134 endoplasmic reticulum membrane|protein transport|vesicle-mediated transport|COPII vesicle coat|COPII-coated ER to Golgi transport vesicle hsa04141 Protein processing in endoplasmic reticulum SEC31B 126.088873791404 115.991000783023 136.186746799786 1.17411476649419 0.231573434819014 0.396614777972331 1 0.654418 0.679002 0.987192 0.796145 GeneID:25956,Genbank:NM_015490.3,HGNC:HGNC:23197,MIM:610258 SEC31 homolog B, COPII coat complex component GO:0005789,GO:0012507,GO:0015031,GO:0016192,GO:0030120 endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|protein transport|vesicle-mediated transport|vesicle coat hsa04141 Protein processing in endoplasmic reticulum SEC61A1 12442.2885260301 11448.9366769029 13435.6403751572 1.17352735492566 0.230851471478148 0.0769278414392696 0.94157495521624 146.881 150.505 185.47 168.711 GeneID:29927,Genbank:NM_013336.3,HGNC:HGNC:18276,MIM:609213 Sec61 translocon alpha 1 subunit GO:0005789,GO:0005791,GO:0006614,GO:0006620,GO:0007029,GO:0016020,GO:0016021,GO:0016049,GO:0022857,GO:0034341,GO:0039019,GO:0043022 endoplasmic reticulum membrane|rough endoplasmic reticulum|SRP-dependent cotranslational protein targeting to membrane|posttranslational protein targeting to endoplasmic reticulum membrane|endoplasmic reticulum organization|membrane|integral component of membrane|cell growth|transmembrane transporter activity|response to interferon-gamma|pronephric nephron development|ribosome binding hsa03060,hsa04141,hsa04145,hsa05110 Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC61A2 293.107327777849 317.243599850663 268.971055705035 0.847837610693007 -0.238140128073565 0.230789042980462 1 4.10826 4.50096 3.72714 3.44923 GeneID:55176,Genbank:NM_001142627.2,HGNC:HGNC:17702 Sec61 translocon alpha 2 subunit GO:0005789,GO:0015031,GO:0016021,GO:0043022 endoplasmic reticulum membrane|protein transport|integral component of membrane|ribosome binding hsa03060,hsa04141,hsa04145,hsa05110 Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC61B 1210.03391787387 1222.6185129697 1197.44932277804 0.979413701064837 -0.0300097167699889 0.851094142555444 1 139.796 124.129 122.996 134.022 GeneID:10952,Genbank:NM_006808.2,HGNC:HGNC:16993,MIM:609214 Sec61 translocon beta subunit GO:0000060,GO:0005086,GO:0005783,GO:0005784,GO:0005789,GO:0006616,GO:0015450,GO:0016021,GO:0030433,GO:0030970,GO:0031204,GO:0031205,GO:0048408 protein import into nucleus, translocation|ARF guanyl-nucleotide exchange factor activity|endoplasmic reticulum|Sec61 translocon complex|endoplasmic reticulum membrane|SRP-dependent cotranslational protein targeting to membrane, translocation|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|integral component of membrane|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|posttranslational protein targeting to membrane, translocation|endoplasmic reticulum Sec complex|epidermal growth factor binding hsa03060,hsa04141,hsa04145,hsa05110 Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC61G 1103.67143642628 1100.03708689887 1107.30578595368 1.00660768545113 0.00950151796822594 0.968992217939797 1 133.065 146.916 138.592 148.612 GeneID:23480,Genbank:NM_001012456.1,HGNC:HGNC:18277,MIM:609215 Sec61 translocon gamma subunit GO:0005543,GO:0005789,GO:0008565,GO:0015450,GO:0022406,GO:0030176,GO:0045047 phospholipid binding|endoplasmic reticulum membrane|protein transporter activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|membrane docking|integral component of endoplasmic reticulum membrane|protein targeting to ER hsa03060,hsa04141,hsa04145,hsa05110 Protein export|Protein processing in endoplasmic reticulum|Phagosome|Vibrio cholerae infection SEC62 1147.67502617712 1203.84968686955 1091.5003654847 0.906674959000068 -0.141342654480577 0.58779712840723 1 6.7785 5.68988 6.48074 4.91001 GeneID:7095,Genbank:XM_011513114.3,HGNC:HGNC:11846,MIM:602173 SEC62 homolog, preprotein translocation factor GO:0004872,GO:0005783,GO:0005789,GO:0005791,GO:0005829,GO:0006613,GO:0006620,GO:0008565,GO:0016020,GO:0016021,GO:0036498 receptor activity|endoplasmic reticulum|endoplasmic reticulum membrane|rough endoplasmic reticulum|cytosol|cotranslational protein targeting to membrane|posttranslational protein targeting to endoplasmic reticulum membrane|protein transporter activity|membrane|integral component of membrane|IRE1-mediated unfolded protein response hsa03060,hsa04141 Protein export|Protein processing in endoplasmic reticulum SEC63 963.648067814193 1016.58966139632 910.706474232065 0.895844713766986 -0.15867941851293 0.384705925620498 1 6.07535 5.50131 6.00657 4.48565 GeneID:11231,Genbank:NM_007214.4,HGNC:HGNC:21082,MIM:608648 SEC63 homolog, protein translocation regulator GO:0001889,GO:0003723,GO:0004872,GO:0005783,GO:0005789,GO:0005829,GO:0006612,GO:0006614,GO:0006620,GO:0006807,GO:0008565,GO:0010259,GO:0016020,GO:0016021,GO:0031204,GO:0036498,GO:0072001 liver development|RNA binding|receptor activity|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|posttranslational protein targeting to endoplasmic reticulum membrane|nitrogen compound metabolic process|protein transporter activity|multicellular organism aging|membrane|integral component of membrane|posttranslational protein targeting to membrane, translocation|IRE1-mediated unfolded protein response|renal system development hsa03060,hsa04141 Protein export|Protein processing in endoplasmic reticulum SECISBP2 669.217603248342 730.145141630673 608.290064866011 0.833108419385608 -0.263423837073681 0.156251284413633 1 4.24724 4.53198 4.30572 3.08493 GeneID:79048,Genbank:NM_024077.4,HGNC:HGNC:30972,MIM:607693 SECIS binding protein 2 GO:0001514,GO:0003723,GO:0003730,GO:0005634,GO:0005739,GO:0021756,GO:0030529,GO:0035368,GO:0043021,GO:0048666,GO:2000623 selenocysteine incorporation|RNA binding|mRNA 3'-UTR binding|nucleus|mitochondrion|striatum development|intracellular ribonucleoprotein complex|selenocysteine insertion sequence binding|ribonucleoprotein complex binding|neuron development|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay SECISBP2L 569.240151926365 618.380453019925 520.099850832806 0.841067741214723 -0.249706092291887 0.438232228359723 1 3.45432 2.8636 3.24482 2.02931 GeneID:9728,Genbank:NM_014701.3,HGNC:HGNC:28997,MIM:615756 SECIS binding protein 2 like GO:0001514,GO:0003723,GO:0003730,GO:0030529,GO:0035368,GO:0043021 selenocysteine incorporation|RNA binding|mRNA 3'-UTR binding|intracellular ribonucleoprotein complex|selenocysteine insertion sequence binding|ribonucleoprotein complex binding SECTM1 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0.0171665 0.036618 0 GeneID:6398,Genbank:NM_003004.2,HGNC:HGNC:10707,MIM:602602 secreted and transmembrane 1 GO:0004871,GO:0005125,GO:0005615,GO:0005794,GO:0005886,GO:0006955,GO:0007498,GO:0016021,GO:0043123,GO:0070062 signal transducer activity|cytokine activity|extracellular space|Golgi apparatus|plasma membrane|immune response|mesoderm development|integral component of membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|extracellular exosome SEH1L 840.374291017306 924.218140456622 756.530441577991 0.818562640638298 -0.28883527149239 0.06955310798487 0.919111037529437 10.2965 9.6173 8.59011 7.56707 GeneID:81929,Genbank:NM_031216.3,HGNC:HGNC:30379,MIM:609263 SEH1 like nucleoporin GO:0000777,GO:0002534,GO:0005635,GO:0005765,GO:0005829,GO:0006110,GO:0006406,GO:0006409,GO:0006999,GO:0007062,GO:0007077,GO:0007080,GO:0016032,GO:0016925,GO:0017056,GO:0019083,GO:0031080,GO:0032008,GO:0034198,GO:0034629,GO:0043657,GO:0050830,GO:0051301,GO:0051315,GO:0060964,GO:0061700,GO:0075733,GO:1900034,GO:1904263 condensed chromosome kinetochore|cytokine production involved in inflammatory response|nuclear envelope|lysosomal membrane|cytosol|regulation of glycolytic process|mRNA export from nucleus|tRNA export from nucleus|nuclear pore organization|sister chromatid cohesion|mitotic nuclear envelope disassembly|mitotic metaphase plate congression|viral process|protein sumoylation|structural constituent of nuclear pore|viral transcription|nuclear pore outer ring|positive regulation of TOR signaling|cellular response to amino acid starvation|cellular protein complex localization|host cell|defense response to Gram-positive bacterium|cell division|attachment of mitotic spindle microtubules to kinetochore|regulation of gene silencing by miRNA|GATOR2 complex|intracellular transport of virus|regulation of cellular response to heat|positive regulation of TORC1 signaling hsa03013,hsa04150 RNA transport|mTOR signaling pathway SEL1L 965.649225418464 968.755786104095 962.542664732834 0.993586493664986 -0.00928253249541701 0.981767771272735 1 4.78119 4.27845 5.12085 4.02761 GeneID:6400,Genbank:NM_005065.5,HGNC:HGNC:10717,MIM:602329 SEL1L ERAD E3 ligase adaptor subunit hsa04141 Protein processing in endoplasmic reticulum SEL1L2 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0 0 0 GeneID:80343,Genbank:XM_017028084.2,HGNC:HGNC:15897,MIM:614289 SEL1L2 ERAD E3 ligase adaptor subunit GO:0016021 integral component of membrane hsa04141 Protein processing in endoplasmic reticulum SEL1L3 3527.79639611292 3278.84405131201 3776.74874091383 1.15185372704828 0.203957521762363 0.131919525487313 1 15.1742 15.745 18.7411 17.2635 GeneID:23231,Genbank:NM_001297592.1,HGNC:HGNC:29108 SEL1L family member 3 GO:0005634,GO:0005654,GO:0016021 nucleus|nucleoplasm|integral component of membrane SELENBP1 2.96876890849995 2.54640955915669 3.3911282578432 1.3317293149678 0.413300872470202 0.922298877783411 1 0.0356583 0 0.0332553 0.0310544 GeneID:8991,Genbank:NM_001258288.1,HGNC:HGNC:10719,MIM:604188 selenium binding protein 1 GO:0001650,GO:0005615,GO:0005730,GO:0005829,GO:0008430,GO:0015031,GO:0016020,GO:0070062 fibrillar center|extracellular space|nucleolus|cytosol|selenium binding|protein transport|membrane|extracellular exosome SELENOF 3107.11671493477 3417.17438882951 2797.05904104004 0.818529791802085 -0.288893167860575 0.0347315222514341 0.730000079237491 99.2698 100.312 77.1213 86.5835 GeneID:9403,Genbank:NM_203341.2,HGNC:HGNC:17705,MIM:606254 selenoprotein F SELENOH 1430.11436886007 1430.28330888492 1429.94542883522 0.999763767046983 -0.000340852371678817 0.980128403687312 1 49.305 58.7973 48.3771 62.5814 GeneID:280636,Genbank:NM_170746.3,HGNC:HGNC:18251,MIM:607914 selenoprotein H GO:0003723 RNA binding SELENOI 534.247075023075 567.279774048267 501.214375997882 0.883540007818498 -0.178632631559789 0.621368883636006 1 3.7134 3.26546 3.98148 2.30795 GeneID:85465,Genbank:NM_033505.3,HGNC:HGNC:29361,MIM:607915 selenoprotein I GO:0004307,GO:0005789,GO:0006646,GO:0016021,GO:0046872,GO:1903955 ethanolaminephosphotransferase activity|endoplasmic reticulum membrane|phosphatidylethanolamine biosynthetic process|integral component of membrane|metal ion binding|positive regulation of protein targeting to mitochondrion hsa00440,hsa00564,hsa00565 Phosphonate and phosphinate metabolism|Glycerophospholipid metabolism|Ether lipid metabolism SELENOK 984.315095030556 1022.76950152388 945.86068853723 0.924803376643455 -0.112781429468889 0.634807197642498 1 35.4985 36.4416 29.1943 38.4854 GeneID:58515,Genbank:NM_021237.4,HGNC:HGNC:30394,MIM:607916 selenoprotein K GO:0002230,GO:0002376,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006816,GO:0006979,GO:0010742,GO:0016021,GO:0018345,GO:0032469,GO:0032760,GO:0042102,GO:0042802,GO:0045728,GO:0050848,GO:0070059,GO:0071639,GO:0090197,GO:2000406,GO:2000778 positive regulation of defense response to virus by host|immune system process|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|calcium ion transport|response to oxidative stress|macrophage derived foam cell differentiation|integral component of membrane|protein palmitoylation|endoplasmic reticulum calcium ion homeostasis|positive regulation of tumor necrosis factor production|positive regulation of T cell proliferation|identical protein binding|respiratory burst after phagocytosis|regulation of calcium-mediated signaling|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of monocyte chemotactic protein-1 production|positive regulation of chemokine secretion|positive regulation of T cell migration|positive regulation of interleukin-6 secretion SELENOM 13.1322069113177 14.1542357269706 12.1101780956647 0.855586859599137 -0.225013769626969 0.8241672311983 1 0.862015 1.46329 0.297014 1.11017 GeneID:140606,Genbank:NM_080430.3,HGNC:HGNC:30397,MIM:610918 selenoprotein M GO:0005783,GO:0005794,GO:0010269,GO:0035264,GO:0035934,GO:0042445,GO:0048471,GO:0060612 endoplasmic reticulum|Golgi apparatus|response to selenium ion|multicellular organism growth|corticosterone secretion|hormone metabolic process|perinuclear region of cytoplasm|adipose tissue development SELENON 3274.03285680976 3231.77082176134 3316.29489185818 1.02615410397535 0.0372474057463401 0.797521732606397 1 29.7122 30.0851 31.9328 30.6087 GeneID:57190,Genbank:NM_020451.2,HGNC:HGNC:15999,MIM:606210 selenoprotein N GO:0005509,GO:0005789,GO:0016491,GO:0048741,GO:0055074,GO:0060314,GO:1902884 calcium ion binding|endoplasmic reticulum membrane|oxidoreductase activity|skeletal muscle fiber development|calcium ion homeostasis|regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of response to oxidative stress SELENOO 541.625172987983 527.423345358015 555.827000617951 1.05385361780043 0.0756744879052088 0.733489074682519 1 12.4499 14.1096 12.8565 14.836 GeneID:83642,Genbank:NM_031454.1,HGNC:HGNC:30395,MIM:607917 selenoprotein O GO:0005739 mitochondrion SELENOP 120.496521945021 104.335148340524 136.657895549519 1.30979729959747 0.389343561768422 0.156412807464277 1 1.59181 1.48833 1.9557 2.04494 GeneID:6414,Genbank:NM_005410.3,HGNC:HGNC:10751,MIM:601484 selenoprotein P SELENOS 1626.34573114941 1642.40067168733 1610.2907906115 0.980449422830036 -0.0284848849842617 0.844787575491603 1 34.247 35.6888 31.7156 36.4613 GeneID:55829,Genbank:NM_203472.2,HGNC:HGNC:30396,MIM:607918 selenoprotein S GO:0002865,GO:0004872,GO:0005783,GO:0005789,GO:0005881,GO:0005886,GO:0006111,GO:0006983,GO:0009749,GO:0016209,GO:0016567,GO:0019899,GO:0030176,GO:0030433,GO:0030968,GO:0030970,GO:0032715,GO:0032720,GO:0032869,GO:0034361,GO:0034362,GO:0034599,GO:0036502,GO:0036513,GO:0045184,GO:0045454,GO:0045719,GO:0046325,GO:0050728,GO:0051117,GO:0051771,GO:0051775,GO:0071222,GO:0080164,GO:1902236,GO:1990381,GO:2000110 negative regulation of acute inflammatory response to antigenic stimulus|receptor activity|endoplasmic reticulum|endoplasmic reticulum membrane|cytoplasmic microtubule|plasma membrane|regulation of gluconeogenesis|ER overload response|response to glucose|antioxidant activity|protein ubiquitination|enzyme binding|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|cellular response to insulin stimulus|very-low-density lipoprotein particle|low-density lipoprotein particle|cellular response to oxidative stress|Derlin-1-VIMP complex|Derlin-1 retrotranslocation complex|establishment of protein localization|cell redox homeostasis|negative regulation of glycogen biosynthetic process|negative regulation of glucose import|negative regulation of inflammatory response|ATPase binding|negative regulation of nitric-oxide synthase biosynthetic process|response to redox state|cellular response to lipopolysaccharide|regulation of nitric oxide metabolic process|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|ubiquitin-specific protease binding|negative regulation of macrophage apoptotic process hsa04141 Protein processing in endoplasmic reticulum SELENOT 1373.44405155361 1479.14128525233 1267.74681785488 0.857082978140667 -0.222493209853072 0.134142019155927 1 21.9976 21.5101 18.285 19.1697 GeneID:51714,Genbank:NM_016275.4,HGNC:HGNC:18136,MIM:607912 selenoprotein T GO:0001514,GO:0004791,GO:0005783,GO:0005789,GO:0007204,GO:0008430,GO:0009749,GO:0016021,GO:0031016,GO:0035773,GO:0042593,GO:0045454,GO:0060124,GO:0098869 selenocysteine incorporation|thioredoxin-disulfide reductase activity|endoplasmic reticulum|endoplasmic reticulum membrane|positive regulation of cytosolic calcium ion concentration|selenium binding|response to glucose|integral component of membrane|pancreas development|insulin secretion involved in cellular response to glucose stimulus|glucose homeostasis|cell redox homeostasis|positive regulation of growth hormone secretion|cellular oxidant detoxification SELENOW 2324.19892040023 2420.92083728943 2227.47700351102 0.920094936274331 -0.120145367385221 0.66395888299682 1 120.237 134.382 101.039 138.357 GeneID:6415,Genbank:NM_003009.3,HGNC:HGNC:10752,MIM:603235 selenoprotein W GO:0005737,GO:0016209 cytoplasm|antioxidant activity SELL 10.4174775430283 9.20549543271206 11.6294596533445 1.26331708470777 0.337216792032254 0.753879505651556 1 0.118993 0.126623 0.114266 0.158792 GeneID:6402,Genbank:NM_000655.4,HGNC:HGNC:10720,MIM:153240 selectin L hsa04514 Cell adhesion molecules (CAMs) SELPLG 32.684929357584 27.5684600234512 37.8013986917168 1.37118281759521 0.455420936145973 0.376234927914578 1 0.287328 0.287855 0.444953 0.393299 GeneID:6404,Genbank:NM_003006.4,HGNC:HGNC:10722,MIM:600738 selectin P ligand hsa04514,hsa05150 Cell adhesion molecules (CAMs)|Staphylococcus aureus infection SEM1 1882.57006247773 1935.70720808123 1829.43291687423 0.945097951403328 -0.0814642346747348 0.57053563181129 1 14.2061 14.278 13.4063 13.5016 GeneID:7979,Genbank:NM_001349702.1,HGNC:HGNC:10845,MIM:601285 SEM1, 26S proteasome complex subunit GO:0000165,GO:0000209,GO:0000502,GO:0002223,GO:0002479,GO:0005654,GO:0005829,GO:0006406,GO:0006521,GO:0008541,GO:0010972,GO:0016579,GO:0031145,GO:0031146,GO:0033209,GO:0038061,GO:0038095,GO:0043161,GO:0043248,GO:0043488,GO:0043687,GO:0050852,GO:0051436,GO:0051437,GO:0055085,GO:0060071,GO:0061418,GO:0070498,GO:0090090,GO:0090263,GO:1902036 MAPK cascade|protein polyubiquitination|proteasome complex|stimulatory C-type lectin receptor signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|nucleoplasm|cytosol|mRNA export from nucleus|regulation of cellular amino acid metabolic process|proteasome regulatory particle, lid subcomplex|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|anaphase-promoting complex-dependent catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|tumor necrosis factor-mediated signaling pathway|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|proteasome assembly|regulation of mRNA stability|post-translational protein modification|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|transmembrane transport|Wnt signaling pathway, planar cell polarity pathway|regulation of transcription from RNA polymerase II promoter in response to hypoxia|interleukin-1-mediated signaling pathway|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|regulation of hematopoietic stem cell differentiation hsa03050,hsa03440,hsa05169 Proteasome|Homologous recombination|Epstein-Barr virus infection SEMA3A 786.608506563244 735.620136944756 837.596876181732 1.13862690010161 0.187295088966733 0.587872136573213 1 3.24669 2.58179 4.08523 2.51084 GeneID:10371,Genbank:XM_024446633.1,HGNC:HGNC:10723,MIM:603961 semaphorin 3A GO:0001764,GO:0002027,GO:0005576,GO:0005615,GO:0006915,GO:0007411,GO:0007413,GO:0010633,GO:0010977,GO:0021612,GO:0021637,GO:0021675,GO:0021772,GO:0021785,GO:0021828,GO:0030215,GO:0030424,GO:0030425,GO:0036486,GO:0038191,GO:0045499,GO:0046330,GO:0048485,GO:0048841,GO:0048843,GO:0048846,GO:0048880,GO:0060385,GO:0060666,GO:0061549,GO:0061551,GO:0071526,GO:0097490,GO:0097491,GO:0140059,GO:1901166,GO:1902285,GO:1902287,GO:1903045,GO:1903375,GO:2000020,GO:2001224 neuron migration|regulation of heart rate|extracellular region|extracellular space|apoptotic process|axon guidance|axonal fasciculation|negative regulation of epithelial cell migration|negative regulation of neuron projection development|facial nerve structural organization|trigeminal nerve structural organization|nerve development|olfactory bulb development|branchiomotor neuron axon guidance|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|semaphorin receptor binding|axon|dendrite|ventral trunk neural crest cell migration|neuropilin binding|chemorepellent activity|positive regulation of JNK cascade|sympathetic nervous system development|regulation of axon extension involved in axon guidance|negative regulation of axon extension involved in axon guidance|axon extension involved in axon guidance|sensory system development|axonogenesis involved in innervation|dichotomous subdivision of terminal units involved in salivary gland branching|sympathetic ganglion development|trigeminal ganglion development|semaphorin-plexin signaling pathway|sympathetic neuron projection extension|sympathetic neuron projection guidance|dendrite arborization|neural crest cell migration involved in autonomic nervous system development|semaphorin-plexin signaling pathway involved in neuron projection guidance|semaphorin-plexin signaling pathway involved in axon guidance|neural crest cell migration involved in sympathetic nervous system development|facioacoustic ganglion development|positive regulation of male gonad development|positive regulation of neuron migration hsa04360 Axon guidance SEMA3B 273.983269155557 293.57711073351 254.389427577604 0.866516558263026 -0.206700776782114 0.560968455804018 1 3.0258 3.83944 2.69529 3.70087 GeneID:7869,Genbank:NM_004636.3,HGNC:HGNC:10724,MIM:601281 semaphorin 3B hsa04360 Axon guidance SEMA3C 2587.27516287681 2708.88527018391 2465.6650555697 0.91021391075832 -0.135722459769256 0.653908314039121 1 21.3159 16.9664 20.9694 14.4228 GeneID:10512,Genbank:NM_001350120.1,HGNC:HGNC:10725,MIM:602645 semaphorin 3C GO:0001755,GO:0001756,GO:0001974,GO:0003148,GO:0003215,GO:0003350,GO:0005615,GO:0006955,GO:0007411,GO:0009791,GO:0021915,GO:0030215,GO:0038191,GO:0042493,GO:0050919,GO:0060174,GO:0060666,GO:0070062,GO:0071526,GO:0140074,GO:1905312 neural crest cell migration|somitogenesis|blood vessel remodeling|outflow tract septum morphogenesis|cardiac right ventricle morphogenesis|pulmonary myocardium development|extracellular space|immune response|axon guidance|post-embryonic development|neural tube development|semaphorin receptor binding|neuropilin binding|response to drug|negative chemotaxis|limb bud formation|dichotomous subdivision of terminal units involved in salivary gland branching|extracellular exosome|semaphorin-plexin signaling pathway|cardiac endothelial to mesenchymal transition|positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis hsa04360 Axon guidance SEMA3D 16.3369836605844 14.7403596782979 17.9336076428709 1.21663297465356 0.282894011512658 0.737117245762122 1 0.0464123 0.0965387 0.106899 0.0680369 GeneID:223117,Genbank:XM_017011873.1,HGNC:HGNC:10726,MIM:609907 semaphorin 3D GO:0005615,GO:0007399,GO:0030154,GO:0038191,GO:0050919 extracellular space|nervous system development|cell differentiation|neuropilin binding|negative chemotaxis hsa04360 Axon guidance SEMA3E 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0.00586702 0.0057044 0 0 GeneID:9723,Genbank:NM_012431.2,HGNC:HGNC:10727,MIM:608166 semaphorin 3E GO:0001569,GO:0001953,GO:0002040,GO:0005576,GO:0005615,GO:0007399,GO:0008360,GO:0016525,GO:0030154,GO:0030215,GO:0038191,GO:0050808,GO:0050919,GO:0071526,GO:2000249 branching involved in blood vessel morphogenesis|negative regulation of cell-matrix adhesion|sprouting angiogenesis|extracellular region|extracellular space|nervous system development|regulation of cell shape|negative regulation of angiogenesis|cell differentiation|semaphorin receptor binding|neuropilin binding|synapse organization|negative chemotaxis|semaphorin-plexin signaling pathway|regulation of actin cytoskeleton reorganization hsa04360 Axon guidance SEMA3F 40.6384419059983 52.6865630371156 28.5903207748809 0.542649190358843 -0.881908263135348 0.0480616697480195 0.805544588686926 0.375081 0.39383 0.206288 0.201813 GeneID:6405,Genbank:NM_001318798.1,HGNC:HGNC:10728,MIM:601124 semaphorin 3F hsa04360 Axon guidance SEMA3G 12.8615394015596 17.9689457381517 7.75413306496754 0.431529661114395 -1.21246836868832 0.136464747795964 1 0.118115 0.135389 0.0633603 0.0517367 GeneID:56920,Genbank:NM_020163.2,HGNC:HGNC:30400 semaphorin 3G GO:0005102,GO:0005615,GO:0030517,GO:0038191,GO:0050919,GO:0070062 receptor binding|extracellular space|negative regulation of axon extension|neuropilin binding|negative chemotaxis|extracellular exosome hsa04360 Axon guidance SEMA4A 2.22139481106861 2.98845468642911 1.45433493570811 0.486651158644767 -1.03904010497772 0.699608453666305 1 0.0122292 0.0216333 0.0228067 0.010676 GeneID:64218,Genbank:XM_011509871.3,HGNC:HGNC:10729,MIM:607292 semaphorin 4A GO:0001525,GO:0005615,GO:0005634,GO:0005829,GO:0005886,GO:0007409,GO:0008360,GO:0010594,GO:0016020,GO:0016021,GO:0016525,GO:0043231,GO:0045063,GO:0050919,GO:0071526 angiogenesis|extracellular space|nucleus|cytosol|plasma membrane|axonogenesis|regulation of cell shape|regulation of endothelial cell migration|membrane|integral component of membrane|negative regulation of angiogenesis|intracellular membrane-bounded organelle|T-helper 1 cell differentiation|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA4B 1456.5916823318 1418.54898720156 1494.63437746204 1.05363606822671 0.0753766381037638 0.619798733529892 1 14.0061 14.2068 15.7988 14.6036 GeneID:10509,Genbank:NM_020210.3,HGNC:HGNC:10730,MIM:617029 semaphorin 4B GO:0005615,GO:0007399,GO:0016021,GO:0030154,GO:0050919 extracellular space|nervous system development|integral component of membrane|cell differentiation|negative chemotaxis hsa04360 Axon guidance SEMA4C 640.600578198916 654.128273399198 627.072882998634 0.958639013935339 -0.0609404400695452 0.696466893029717 1 5.11727 5.36441 5.07309 5.42258 GeneID:54910,Genbank:XM_011511380.1,HGNC:HGNC:10731,MIM:604462 semaphorin 4C GO:0001843,GO:0005615,GO:0014069,GO:0016020,GO:0016021,GO:0021535,GO:0021549,GO:0030054,GO:0030672,GO:0032874,GO:0042692,GO:0045211,GO:0050919,GO:0071526 neural tube closure|extracellular space|postsynaptic density|membrane|integral component of membrane|cell migration in hindbrain|cerebellum development|cell junction|synaptic vesicle membrane|positive regulation of stress-activated MAPK cascade|muscle cell differentiation|postsynaptic membrane|negative chemotaxis|semaphorin-plexin signaling pathway hsa04360 Axon guidance SEMA4D 257.841621301107 253.957762414118 261.725480188096 1.03058665228477 0.0434658125586813 0.833134203346108 1 0.729712 0.648116 0.793053 0.624258 GeneID:10507,Genbank:NM_001142287.1,HGNC:HGNC:10732,MIM:601866 semaphorin 4D hsa04360 Axon guidance SEMA4F 553.262008485746 532.726869884429 573.797147087064 1.07709443529955 0.107144745114823 0.54056625493656 1 1.73922 1.93272 2.0237 1.95991 GeneID:10505,Genbank:NM_004263.4,HGNC:HGNC:10734,MIM:603706 ssemaphorin 4F GO:0005615,GO:0005783,GO:0005886,GO:0005887,GO:0007267,GO:0007399,GO:0007411,GO:0016020,GO:0030517,GO:0031290,GO:0045211,GO:0050919 extracellular space|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|cell-cell signaling|nervous system development|axon guidance|membrane|negative regulation of axon extension|retinal ganglion cell axon guidance|postsynaptic membrane|negative chemotaxis hsa04360 Axon guidance SEMA4G 9.70575435931151 12.1459238444562 7.26558487416678 0.598191209430563 -0.741321385038784 0.433717917758695 1 0.00907405 0.0319084 0.00844642 0.0632103 GeneID:57715,Genbank:XM_024448090.1,HGNC:HGNC:10735 semaphorin 4G GO:0005615,GO:0005886,GO:0007399,GO:0016021,GO:0030154,GO:0050919 extracellular space|plasma membrane|nervous system development|integral component of membrane|cell differentiation|negative chemotaxis hsa04360 Axon guidance SEMA5A 487.81368640266 485.14191761988 490.48545518544 1.01101438026995 0.0158035177123467 0.915399201470272 1 1.23608 1.11581 1.38919 1.09153 GeneID:9037,Genbank:NM_003966.2,HGNC:HGNC:10736,MIM:609297 semaphorin 5A GO:0001938,GO:0002043,GO:0005615,GO:0005886,GO:0007155,GO:0007162,GO:0007267,GO:0007399,GO:0007413,GO:0016020,GO:0016021,GO:0021536,GO:0030215,GO:0030836,GO:0035373,GO:0035413,GO:0038191,GO:0043395,GO:0045545,GO:0045766,GO:0048842,GO:0048843,GO:0050918,GO:0050919,GO:0051897,GO:0060326,GO:0070062,GO:1990256,GO:2000352,GO:2001028 positive regulation of endothelial cell proliferation|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|extracellular space|plasma membrane|cell adhesion|negative regulation of cell adhesion|cell-cell signaling|nervous system development|axonal fasciculation|membrane|integral component of membrane|diencephalon development|semaphorin receptor binding|positive regulation of actin filament depolymerization|chondroitin sulfate proteoglycan binding|positive regulation of catenin import into nucleus|neuropilin binding|heparan sulfate proteoglycan binding|syndecan binding|positive regulation of angiogenesis|positive regulation of axon extension involved in axon guidance|negative regulation of axon extension involved in axon guidance|positive chemotaxis|negative chemotaxis|positive regulation of protein kinase B signaling|cell chemotaxis|extracellular exosome|signal clustering|negative regulation of endothelial cell apoptotic process|positive regulation of endothelial cell chemotaxis hsa04360 Axon guidance SEMA5B 0.969266633120943 0 1.93853326624189 Inf Inf 0.451830900262006 1 0 0 0.0159132 0.00743153 GeneID:54437,Genbank:NM_001256348.1,HGNC:HGNC:10737,MIM:609298 semaphorin 5B GO:0005615,GO:0016021,GO:0038191,GO:0048675,GO:0050908,GO:0050919,GO:0097485 extracellular space|integral component of membrane|neuropilin binding|axon extension|detection of light stimulus involved in visual perception|negative chemotaxis|neuron projection guidance hsa04360 Axon guidance SEMA6A 74.9883332050702 58.3753147618642 91.6013516482762 1.56917957568116 0.65001046264384 0.0601749604603508 0.879410748501007 0.19405 0.299085 0.44968 0.368784 GeneID:57556,Genbank:NM_020796.4,HGNC:HGNC:10738,MIM:605885 semaphorin 6A GO:0005887,GO:0006915,GO:0007010,GO:0007166,GO:0007399,GO:0007411,GO:0009887,GO:0016021,GO:0030424,GO:1903671,GO:2001224 integral component of plasma membrane|apoptotic process|cytoskeleton organization|cell surface receptor signaling pathway|nervous system development|axon guidance|animal organ morphogenesis|integral component of membrane|axon|negative regulation of sprouting angiogenesis|positive regulation of neuron migration hsa04360 Axon guidance SEMA6B 2590.62124986444 2767.99216607545 2413.25033365342 0.871841460835856 -0.19786228151435 0.31066293477184 1 32.1445 35.7694 28.3259 32.8299 GeneID:10501,Genbank:XM_011527640.2,HGNC:HGNC:10739,MIM:608873 semaphorin 6B GO:0005887,GO:0007399,GO:0030154,GO:0030215 integral component of plasma membrane|nervous system development|cell differentiation|semaphorin receptor binding hsa04360 Axon guidance SEMA6C 53.3859105901424 48.6219129974019 58.1499081828828 1.19596092786374 0.258170257347052 0.528948334826108 1 0.188533 0.261946 0.31782 0.369269 GeneID:10500,Genbank:NM_001178062.1,HGNC:HGNC:10740,MIM:609294 semaphorin 6C GO:0005887,GO:0007411 integral component of plasma membrane|axon guidance hsa04360 Axon guidance SEMA6D 13.364843230346 11.7038787171838 15.0258077435081 1.28383146361958 0.360455823520017 0.691412235359992 1 0.0249624 0.0351066 0.0675804 0.0481113 GeneID:80031,Genbank:XM_017022617.2,HGNC:HGNC:16770,MIM:609295 semaphorin 6D GO:0005886,GO:0007399,GO:0016021,GO:0030154 plasma membrane|nervous system development|integral component of membrane|cell differentiation hsa04360 Axon guidance SEMA7A 222.156756158877 284.370598299943 159.94291401781 0.562445326535159 -0.830215231393536 0.000172917541400103 0.0324179529825308 3.08198 2.85026 2.14545 1.47162 GeneID:8482,Genbank:NM_001146029.2,HGNC:HGNC:10741,MIM:607961 semaphorin 7A (John Milton Hagen blood group) hsa04360 Axon guidance SENP1 372.57841175156 390.358257289971 354.798566213149 0.908904985579933 -0.13779860794566 0.550166972484061 1 2.35855 2.26957 2.60553 1.80682 GeneID:29843,Genbank:XM_017019237.1,HGNC:HGNC:17927,MIM:612157 SUMO specific peptidase 1 GO:0004175,GO:0005634,GO:0005654,GO:0005737,GO:0005925,GO:0006508,GO:0006919,GO:0010724,GO:0016925,GO:0016926,GO:0031965,GO:0032435,GO:0045944,GO:0070139,GO:0070140,GO:0097190 endopeptidase activity|nucleus|nucleoplasm|cytoplasm|focal adhesion|proteolysis|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of definitive erythrocyte differentiation|protein sumoylation|protein desumoylation|nuclear membrane|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|SUMO-specific endopeptidase activity|SUMO-specific isopeptidase activity|apoptotic signaling pathway SENP2 1195.76435497173 1273.44963460261 1118.07907534085 0.877992379879051 -0.187719676263871 0.216968565195952 1 14.3344 13.0602 12.8042 11.2918 GeneID:59343,Genbank:NM_021627.2,HGNC:HGNC:23116,MIM:608261 SUMO specific peptidase 2 GO:0001934,GO:0004175,GO:0005643,GO:0005654,GO:0005829,GO:0007507,GO:0009950,GO:0015031,GO:0016055,GO:0016605,GO:0016925,GO:0016926,GO:0016929,GO:0019904,GO:0030111,GO:0031397,GO:0031398,GO:0031410,GO:0031648,GO:0031965,GO:0032091,GO:0032875,GO:0035562,GO:0043518,GO:0045444,GO:0045944,GO:0051028,GO:0060707,GO:0060711,GO:0060712,GO:0070139,GO:0070140,GO:2000045 positive regulation of protein phosphorylation|endopeptidase activity|nuclear pore|nucleoplasm|cytosol|heart development|dorsal/ventral axis specification|protein transport|Wnt signaling pathway|PML body|protein sumoylation|protein desumoylation|SUMO-specific protease activity|protein domain specific binding|regulation of Wnt signaling pathway|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|cytoplasmic vesicle|protein destabilization|nuclear membrane|negative regulation of protein binding|regulation of DNA endoreduplication|negative regulation of chromatin binding|negative regulation of DNA damage response, signal transduction by p53 class mediator|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|mRNA transport|trophoblast giant cell differentiation|labyrinthine layer development|spongiotrophoblast layer development|SUMO-specific endopeptidase activity|SUMO-specific isopeptidase activity|regulation of G1/S transition of mitotic cell cycle hsa03013,hsa04310 RNA transport|Wnt signaling pathway SENP3 4335.66405942887 4263.20873804215 4408.11938081559 1.03399097995844 0.0482236003279086 0.732756314227156 1 63.9078 66.3997 69.5244 68.2275 GeneID:26168,Genbank:NM_015670.5,HGNC:HGNC:17862,MIM:612844 SUMO specific peptidase 3 GO:0004175,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0008234,GO:0016926,GO:0071339 endopeptidase activity|nucleus|nucleoplasm|nucleolus|cytoplasm|rRNA processing|cysteine-type peptidase activity|protein desumoylation|MLL1 complex SENP5 1228.98388230322 1332.14151597705 1125.82624862939 0.845125112555074 -0.242763160709679 0.108165439133506 1 8.57364 7.8021 7.44548 6.52082 GeneID:205564,Genbank:NM_152699.4,HGNC:HGNC:28407,MIM:612845 SUMO specific peptidase 5 GO:0004175,GO:0005634,GO:0005654,GO:0005730,GO:0007049,GO:0016925,GO:0016926,GO:0051301,GO:0070139 endopeptidase activity|nucleus|nucleoplasm|nucleolus|cell cycle|protein sumoylation|protein desumoylation|cell division|SUMO-specific endopeptidase activity SENP6 444.820539832063 463.098513186906 426.54256647722 0.921062267166181 -0.118629403831025 0.684988112774398 1 1.97521 1.70419 2.01385 1.407 GeneID:26054,Genbank:NM_015571.3,HGNC:HGNC:20944,MIM:605003 SUMO specific peptidase 6 GO:0005654,GO:0005829,GO:0016925,GO:0016926,GO:0016929,GO:0070646,GO:0090169,GO:0090234 nucleoplasm|cytosol|protein sumoylation|protein desumoylation|SUMO-specific protease activity|protein modification by small protein removal|regulation of spindle assembly|regulation of kinetochore assembly SENP7 52.8447793973817 50.4283111260686 55.2612476686947 1.0958377632466 0.132034225775938 0.76552993495632 1 0.242385 0.219498 0.338081 0.129363 GeneID:57337,Genbank:NM_001282803.1,HGNC:HGNC:30402,MIM:612846 SUMO specific peptidase 7 GO:0004930,GO:0005622,GO:0005634,GO:0005886,GO:0007188,GO:0008234 G-protein coupled receptor activity|intracellular|nucleus|plasma membrane|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|cysteine-type peptidase activity SENP8 58.9939868183806 54.9830325677397 63.0049410690215 1.14589789116122 0.196478493939065 0.610672580553124 1 0.306135 0.34394 0.416856 0.388272 GeneID:123228,Genbank:NM_001166340.1,HGNC:HGNC:22992,MIM:608659 SUMO peptidase family member, NEDD8 specific GO:0004175,GO:0005634,GO:0005829,GO:0016579,GO:0016926,GO:0019784,GO:0043687 endopeptidase activity|nucleus|cytosol|protein deubiquitination|protein desumoylation|NEDD8-specific protease activity|post-translational protein modification SEPHS1 2308.48150607097 2332.419827289 2284.54318485294 0.979473402739976 -0.0299217777453105 0.814401041022842 1 23.4944 25.3212 24.7523 23.1664 GeneID:22929,Genbank:XM_017015944.2,HGNC:HGNC:19685,MIM:600902 selenophosphate synthetase 1 GO:0004756,GO:0005524,GO:0005525,GO:0005737,GO:0005886,GO:0006464,GO:0016260,GO:0031965,GO:0042802,GO:0042803,GO:0046982 selenide, water dikinase activity|ATP binding|GTP binding|cytoplasm|plasma membrane|cellular protein modification process|selenocysteine biosynthetic process|nuclear membrane|identical protein binding|protein homodimerization activity|protein heterodimerization activity hsa00450 Selenocompound metabolism SEPHS2 1541.24143796338 1546.75253841309 1535.73033751368 0.992873972645475 -0.0103174894984829 0.938526370440081 1 30.5664 31.904 30.9024 31.9314 GeneID:22928,Genbank:NM_012248.3,HGNC:HGNC:19686,MIM:606218 selenophosphate synthetase 2 GO:0001887,GO:0004756,GO:0005524,GO:0005829,GO:0016259,GO:0016260 selenium compound metabolic process|selenide, water dikinase activity|ATP binding|cytosol|selenocysteine metabolic process|selenocysteine biosynthetic process hsa00450 Selenocompound metabolism SEPSECS 83.3079287912399 90.0368337894982 76.5790237929817 0.85052995057578 -0.233566055017103 0.484817993555064 1 0.643793 0.569897 0.613204 0.425864 GeneID:51091,Genbank:NM_016955.3,HGNC:HGNC:30605,MIM:613009 Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase GO:0000049,GO:0001514,GO:0005634,GO:0005737,GO:0005829,GO:0016259,GO:0097056,GO:0098621 tRNA binding|selenocysteine incorporation|nucleus|cytoplasm|cytosol|selenocysteine metabolic process|selenocysteinyl-tRNA(Sec) biosynthetic process|phosphoseryl-selenocysteinyl-tRNA selenium transferase activity hsa00450,hsa00970 Selenocompound metabolism|Aminoacyl-tRNA biosynthesis SEPT1 35.8245325310965 35.3037412502912 36.3453238119019 1.02950346124016 0.0419486803884505 0.968598142869043 1 0.357742 0.378603 0.308028 0.309506 GeneID:1731,Genbank:NM_052838.4,HGNC:HGNC:2879,MIM:612897 septin 1 GO:0005525,GO:0005737,GO:0005815,GO:0007049,GO:0030496,GO:0042802,GO:0051301 GTP binding|cytoplasm|microtubule organizing center|cell cycle|midbody|identical protein binding|cell division hsa05100 Bacterial invasion of epithelial cells SEPT10 530.261492096962 557.920391136392 502.602593057532 0.900850015597767 -0.150641166168457 0.489617802410514 1 4.52972 3.70572 4.17039 3.20234 GeneID:151011,Genbank:NM_001321503.1,HGNC:HGNC:14349,MIM:611737 septin 10 GO:0005525,GO:0005737,GO:0005856,GO:0007049,GO:0051301 GTP binding|cytoplasm|cytoskeleton|cell cycle|cell division SEPT11 1966.36286158052 2027.42292748299 1905.30279567806 0.939765832698485 -0.0896267786194174 0.70186213212124 1 11.8787 10.2552 12.2112 8.82752 GeneID:55752,Genbank:NM_001306147.1,HGNC:HGNC:25589,MIM:612887 septin 11 GO:0001725,GO:0005525,GO:0005737,GO:0007049,GO:0030054,GO:0030424,GO:0043197,GO:0051291,GO:0051301 stress fiber|GTP binding|cytoplasm|cell cycle|cell junction|axon|dendritic spine|protein heterooligomerization|cell division hsa05100 Bacterial invasion of epithelial cells SEPT2 8156.01426662787 8341.13866482394 7970.88986843179 0.955611720261461 -0.0655035468074365 0.641648003671123 1 67.9209 60.0794 64.8287 58.2496 GeneID:4735,Genbank:NM_001008491.2,HGNC:HGNC:7729,MIM:601506 septin 2 GO:0002036,GO:0005525,GO:0005634,GO:0005737,GO:0005819,GO:0005930,GO:0007049,GO:0007224,GO:0007283,GO:0030154,GO:0030234,GO:0030496,GO:0031105,GO:0032154,GO:0032391,GO:0032880,GO:0032947,GO:0043209,GO:0045202,GO:0045296,GO:0051301,GO:0060170,GO:0060271,GO:0097227 regulation of L-glutamate transport|GTP binding|nucleus|cytoplasm|spindle|axoneme|cell cycle|smoothened signaling pathway|spermatogenesis|cell differentiation|enzyme regulator activity|midbody|septin complex|cleavage furrow|photoreceptor connecting cilium|regulation of protein localization|protein complex scaffold activity|myelin sheath|synapse|cadherin binding|cell division|ciliary membrane|cilium assembly|sperm annulus hsa05100 Bacterial invasion of epithelial cells SEPT3 147.988190702151 136.506356080331 159.47002532397 1.16822417580413 0.224317146039782 0.434826434243722 1 0.656614 0.666468 0.942027 0.629473 GeneID:55964,Genbank:XM_017028862.1,HGNC:HGNC:10750,MIM:608314 septin 3 GO:0005525,GO:0005737,GO:0005856,GO:0007049,GO:0030054,GO:0042802,GO:0045202,GO:0051301 GTP binding|cytoplasm|cytoskeleton|cell cycle|cell junction|identical protein binding|synapse|cell division hsa05100 Bacterial invasion of epithelial cells SEPT4 435.492516249429 379.097440700914 491.887591797944 1.29752285029541 0.37575994568727 0.0403618085650164 0.758464027333929 2.20172 2.42561 3.20059 3.19418 GeneID:5414,Genbank:NM_001198713.1,HGNC:HGNC:9165,MIM:603696 septin 4 GO:0000287,GO:0003924,GO:0005198,GO:0005525,GO:0005634,GO:0005654,GO:0005739,GO:0006915,GO:0007049,GO:0007420,GO:0030382,GO:0031105,GO:0031398,GO:0042803,GO:0042981,GO:0043065,GO:0043209,GO:0048240,GO:0051260,GO:0051301,GO:0097227,GO:2001244 magnesium ion binding|GTPase activity|structural molecule activity|GTP binding|nucleus|nucleoplasm|mitochondrion|apoptotic process|cell cycle|brain development|sperm mitochondrion organization|septin complex|positive regulation of protein ubiquitination|protein homodimerization activity|regulation of apoptotic process|positive regulation of apoptotic process|myelin sheath|sperm capacitation|protein homooligomerization|cell division|sperm annulus|positive regulation of intrinsic apoptotic signaling pathway hsa04210,hsa04215 Apoptosis|Apoptosis - multiple species SEPT5 164.059635785396 166.275233085036 161.844038485756 0.973350242744725 -0.0389690683500521 0.889074912958549 1 2.746 2.55522 2.36199 2.77242 GeneID:5413,Genbank:NM_002688.5,HGNC:HGNC:9164,MIM:602724 septin 5 GO:0005525,GO:0005856,GO:0005886,GO:0007049,GO:0008021,GO:0017157,GO:0051301 GTP binding|cytoskeleton|plasma membrane|cell cycle|synaptic vesicle|regulation of exocytosis|cell division hsa05012 Parkinson disease SEPT6 418.703808152103 418.215891962386 419.19172434182 1.00233332209079 0.00336235100895011 1 1 2.10164 2.3555 2.37929 2.34511 GeneID:23157,Genbank:NM_145802.3,HGNC:HGNC:15848,MIM:300683 septin 6 hsa05100 Bacterial invasion of epithelial cells SEPT7 1460.38042262557 1558.89337725327 1361.86746799786 0.873611683691567 -0.194935943882383 0.454058328059567 1 11.3016 8.6888 9.54859 8.20539 GeneID:989,Genbank:NM_001788.5,HGNC:HGNC:1717,MIM:603151 septin 7 GO:0000777,GO:0000910,GO:0001725,GO:0005198,GO:0005525,GO:0005634,GO:0005819,GO:0005829,GO:0005930,GO:0007283,GO:0016476,GO:0030154,GO:0030496,GO:0031105,GO:0032154,GO:0042802,GO:0045296,GO:0051291,GO:0060271,GO:0070062,GO:0097227,GO:0097730,GO:1902857 condensed chromosome kinetochore|cytokinesis|stress fiber|structural molecule activity|GTP binding|nucleus|spindle|cytosol|axoneme|spermatogenesis|regulation of embryonic cell shape|cell differentiation|midbody|septin complex|cleavage furrow|identical protein binding|cadherin binding|protein heterooligomerization|cilium assembly|extracellular exosome|sperm annulus|non-motile cilium|positive regulation of non-motile cilium assembly SEPT8 1987.59514267521 1959.11394851474 2016.07633683567 1.02907558713678 0.0413489542264176 0.755188688990695 1 12.0123 11.1256 12.4296 11.3944 GeneID:23176,Genbank:NM_001098811.1,HGNC:HGNC:16511,MIM:608418 septin 8 GO:0005525,GO:0005737,GO:0005856 GTP binding|cytoplasm|cytoskeleton hsa05100 Bacterial invasion of epithelial cells SEPT9 10156.4087024635 9774.89613749986 10537.921267427 1.07805966623011 0.108437027619309 0.416736775177753 1 49.2178 50.3879 54.4626 55.522 GeneID:10801,Genbank:NM_001113491.1,HGNC:HGNC:7323,MIM:604061 septin 9 hsa05100 Bacterial invasion of epithelial cells SERAC1 669.527196908579 669.722280365862 669.332113451295 0.999417419838035 -0.000840730430808508 0.990035319610845 1 5.42028 4.73649 5.96016 4.47088 GeneID:84947,Genbank:NM_032861.3,HGNC:HGNC:21061,MIM:614725 serine active site containing 1 GO:0005578,GO:0005739,GO:0005783,GO:0008654,GO:0016021,GO:0030198,GO:0032367,GO:0036148,GO:0044233 proteinaceous extracellular matrix|mitochondrion|endoplasmic reticulum|phospholipid biosynthetic process|integral component of membrane|extracellular matrix organization|intracellular cholesterol transport|phosphatidylglycerol acyl-chain remodeling|ER-mitochondrion membrane contact site SERBP1 8064.835931662 8817.80935778991 7311.86250553409 0.829215308343514 -0.270181344253577 0.0410610425156491 0.759435523043776 47.0056 46.601 41.4139 35.9796 GeneID:26135,Genbank:NM_015640.3,HGNC:HGNC:17860,MIM:607378 SERPINE1 mRNA binding protein 1 GO:0003723,GO:0003730,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0042981,GO:0043488,GO:0045296,GO:0048471,GO:0070062 RNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|cytosol|plasma membrane|membrane|regulation of apoptotic process|regulation of mRNA stability|cadherin binding|perinuclear region of cytoplasm|extracellular exosome SERF1A 2.50651715165025 2.10436443188427 2.90866987141623 1.38220824651164 0.466974991685868 0.907564573450322 1 0.0438799 0.0204713 0.0838177 0.0388823 GeneID:8293,Genbank:NM_021967.2,HGNC:HGNC:10755,MIM:603011 small EDRK-rich factor 1A GO:0007399 nervous system development SERF1B 27.4781487832532 23.9458551110099 31.0104424554964 1.2950233897155 0.372978154994325 0.518682090411829 1 0.330429 0.411 0.336196 0.545885 GeneID:728492,Genbank:NM_022978.2,HGNC:HGNC:10756 small EDRK-rich factor 1B GO:0007399 nervous system development SERF2 10108.9275187469 9696.67006063288 10521.1849768609 1.08503072818528 0.117735900524853 0.562082132734459 1 37.9619 41.2278 39.9081 49.7064 GeneID:10169,Genbank:NM_001199877.1,HGNC:HGNC:10757,MIM:605054 small EDRK-rich factor 2 GO:0008654,GO:0015194,GO:0016021 phospholipid biosynthetic process|L-serine transmembrane transporter activity|integral component of membrane SERGEF 312.929209574241 305.53972113348 320.318698015003 1.04837006732446 0.0681480680702337 0.749389210933889 1 6.95879 7.58241 7.30779 8.02282 GeneID:26297,Genbank:NM_012139.3,HGNC:HGNC:17499,MIM:606051 secretion regulating guanine nucleotide exchange factor GO:0005087,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0016235,GO:0043231,GO:0050709 Ran guanyl-nucleotide exchange factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|signal transduction|aggresome|intracellular membrane-bounded organelle|negative regulation of protein secretion SERHL2 9.69324661088603 9.69556683466942 9.69092638710264 0.999521384603303 -0.000690661353074745 1 1 0 0.154213 0.107913 0.176513 GeneID:253190,Genbank:XM_017028739.2,HGNC:HGNC:29446 serine hydrolase like 2 GO:0005739,GO:0005777,GO:0016787,GO:0031410,GO:0048471 mitochondrion|peroxisome|hydrolase activity|cytoplasmic vesicle|perinuclear region of cytoplasm SERINC1 3060.7716504222 2948.93873689959 3172.60456394481 1.07584621011163 0.105471862498083 0.561275686042401 1 44.5557 36.9141 49.0251 39.5146 GeneID:57515,Genbank:NM_020755.3,HGNC:HGNC:13464,MIM:614548 serine incorporator 1 GO:0005789,GO:0005886,GO:0006658,GO:0006665,GO:0008654,GO:0015194,GO:0016021,GO:0019899,GO:0030674,GO:0044091,GO:0070062,GO:1904219,GO:1904222 endoplasmic reticulum membrane|plasma membrane|phosphatidylserine metabolic process|sphingolipid metabolic process|phospholipid biosynthetic process|L-serine transmembrane transporter activity|integral component of membrane|enzyme binding|protein binding, bridging|membrane biogenesis|extracellular exosome|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|positive regulation of serine C-palmitoyltransferase activity SERINC2 243.927757430208 228.109456625071 259.746058235345 1.1386904430809 0.187375598730902 0.377038295106842 1 3.37374 2.93154 3.4175 3.6672 GeneID:347735,Genbank:NM_001199038.1,HGNC:HGNC:23231,MIM:614549 serine incorporator 2 GO:0006658,GO:0006665,GO:0015194,GO:0016021,GO:0070062,GO:1904219,GO:1904222 phosphatidylserine metabolic process|sphingolipid metabolic process|L-serine transmembrane transporter activity|integral component of membrane|extracellular exosome|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|positive regulation of serine C-palmitoyltransferase activity SERINC3 3954.93809090243 3863.48601283603 4046.39016896883 1.04734174150628 0.0667322620694986 0.610015475485824 1 36.0576 35.7446 41.6512 34.6336 GeneID:10955,Genbank:NM_198941.2,HGNC:HGNC:11699,MIM:607165 serine incorporator 3 GO:0000139,GO:0005886,GO:0006564,GO:0006658,GO:0006665,GO:0009597,GO:0015194,GO:0016021,GO:0045087,GO:0048471,GO:0051607,GO:1902237 Golgi membrane|plasma membrane|L-serine biosynthetic process|phosphatidylserine metabolic process|sphingolipid metabolic process|detection of virus|L-serine transmembrane transporter activity|integral component of membrane|innate immune response|perinuclear region of cytoplasm|defense response to virus|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway SERINC4 27.526320351588 33.7374744950492 21.3151662081268 0.631794955821446 -0.66247167606854 0.22802499461566 1 0.30811 0.246222 0.050806 0.126583 GeneID:619189,Genbank:NM_001258031.1,HGNC:HGNC:32237,MIM:614550 serine incorporator 4 GO:0008654,GO:0015194,GO:0016021 phospholipid biosynthetic process|L-serine transmembrane transporter activity|integral component of membrane SERINC5 4675.20494572974 4638.64906286102 4711.76082859846 1.01576143500977 0.0225616059069629 0.856075755703155 1 28.932 28.2879 32.0409 27.456 GeneID:256987,Genbank:NM_001174071.2,HGNC:HGNC:18825,MIM:614551 serine incorporator 5 GO:0005794,GO:0005886,GO:0006564,GO:0006658,GO:0006665,GO:0008654,GO:0009597,GO:0015194,GO:0016021,GO:0016032,GO:0042552,GO:0043209,GO:0045087,GO:0048471,GO:0051607,GO:0070062,GO:1904219,GO:1904222 Golgi apparatus|plasma membrane|L-serine biosynthetic process|phosphatidylserine metabolic process|sphingolipid metabolic process|phospholipid biosynthetic process|detection of virus|L-serine transmembrane transporter activity|integral component of membrane|viral process|myelination|myelin sheath|innate immune response|perinuclear region of cytoplasm|defense response to virus|extracellular exosome|positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity|positive regulation of serine C-palmitoyltransferase activity SERP1 1395.44537146762 1462.01922915 1328.87151378524 0.908928889093905 -0.1377606666557 0.346021383463547 1 25.3166 26.3422 24.4673 22.8423 GeneID:27230,Genbank:NM_014445.3,HGNC:HGNC:10759,MIM:617674 stress associated endoplasmic reticulum protein 1 GO:0001501,GO:0005783,GO:0005789,GO:0005829,GO:0005840,GO:0005881,GO:0006006,GO:0006464,GO:0006486,GO:0006950,GO:0007009,GO:0009791,GO:0010259,GO:0015031,GO:0016021,GO:0030968,GO:0032024,GO:0036498,GO:0045727,GO:0046622,GO:0048644,GO:0060124 skeletal system development|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|ribosome|cytoplasmic microtubule|glucose metabolic process|cellular protein modification process|protein glycosylation|response to stress|plasma membrane organization|post-embryonic development|multicellular organism aging|protein transport|integral component of membrane|endoplasmic reticulum unfolded protein response|positive regulation of insulin secretion|IRE1-mediated unfolded protein response|positive regulation of translation|positive regulation of organ growth|muscle organ morphogenesis|positive regulation of growth hormone secretion SERP2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:387923,Genbank:XM_024449348.1,HGNC:HGNC:20607 stress associated endoplasmic reticulum protein family member 2 GO:0005783,GO:0005789,GO:0006486,GO:0015031,GO:0016021,GO:0030968 endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|protein transport|integral component of membrane|endoplasmic reticulum unfolded protein response SERPINA1 5.1586459331708 4.01662376502878 6.30066810131283 1.56864781714692 0.649521483926018 0.694306954271042 1 0.00985625 0.0531647 0.0370124 0.0433456 GeneID:5265,Genbank:NM_001002235.2,HGNC:HGNC:8941,MIM:107400 serpin family A member 1 hsa04610 Complement and coagulation cascades SERPINA3 28.1372904851363 24.7721104357619 31.5024705345107 1.27169102593022 0.346748191451738 0.523286230987334 1 0.584638 0.403458 0.704121 0.554783 GeneID:12,Genbank:NM_001085.4,HGNC:HGNC:16,MIM:107280 serpin family A member 3 SERPINA5 133.954876831264 128.338838381326 139.570915281202 1.08751892288835 0.121040504151867 0.6706423026945 1 1.72641 2.04057 2.06944 2.03767 GeneID:5104,Genbank:NM_000624.5,HGNC:HGNC:8723,MIM:601841 serpin family A member 5 hsa04610 Complement and coagulation cascades SERPINA6 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0236151 GeneID:866,Genbank:NM_001756.3,HGNC:HGNC:1540,MIM:122500 serpin family A member 6 SERPINA7 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0305331 0 GeneID:6906,Genbank:XM_006724683.2,HGNC:HGNC:11583,MIM:314200 serpin family A member 7 GO:0004867,GO:0005576,GO:0005615,GO:0070062,GO:0070327 serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|extracellular exosome|thyroid hormone transport hsa04918 Thyroid hormone synthesis SERPINA9 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0218519 0 0 0 GeneID:327657,Genbank:NM_001284275.1,HGNC:HGNC:15995,MIM:615677 serpin family A member 9 GO:0004867,GO:0005615,GO:0005737,GO:0016020 serine-type endopeptidase inhibitor activity|extracellular space|cytoplasm|membrane SERPINB1 0.97720626820293 1.47021420587209 0.484198330533773 0.329338628752101 -1.60235635659317 0.793508671995383 1 0 0 0 0.0131749 GeneID:1992,Genbank:NM_030666.3,HGNC:HGNC:3311,MIM:130135 serpin family B member 1 GO:0004867,GO:0005576,GO:0005615,GO:0016020,GO:0031012,GO:0034774,GO:0043312,GO:0070062 serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|membrane|extracellular matrix|secretory granule lumen|neutrophil degranulation|extracellular exosome hsa05146 Amoebiasis SERPINB2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:5055,Genbank:NM_001143818.1,HGNC:HGNC:8584,MIM:173390 serpin family B member 2 GO:0004867,GO:0005576,GO:0005615,GO:0005737,GO:0005886,GO:0035722,GO:0042060,GO:0042730,GO:0043066 serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|cytoplasm|plasma membrane|interleukin-12-mediated signaling pathway|wound healing|fibrinolysis|negative regulation of apoptotic process hsa04610 Complement and coagulation cascades SERPINB5 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0140538 0 GeneID:5268,Genbank:NM_002639.4,HGNC:HGNC:8949,MIM:154790 serpin family B member 5 hsa04115,hsa05206 p53 signaling pathway|MicroRNAs in cancer SERPINB6 3641.46348702474 3490.85962091335 3792.06735313613 1.08628468770794 0.11940224653124 0.382505031912755 1 23.1384 24.2184 25.6626 26.6169 GeneID:5269,Genbank:NM_001297700.1,HGNC:HGNC:8950,MIM:173321 serpin family B member 6 GO:0002020,GO:0004867,GO:0005576,GO:0005615,GO:0005737,GO:0005829,GO:0005886,GO:0007605,GO:0010951,GO:0030667,GO:0043312,GO:0070062,GO:0070821,GO:0071470,GO:0097180,GO:0101003 protease binding|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|cytoplasm|cytosol|plasma membrane|sensory perception of sound|negative regulation of endopeptidase activity|secretory granule membrane|neutrophil degranulation|extracellular exosome|tertiary granule membrane|cellular response to osmotic stress|serine protease inhibitor complex|ficolin-1-rich granule membrane hsa05146 Amoebiasis SERPINB7 15.744129571975 17.4308480615094 14.0574110824406 0.806467421024797 -0.310311841079058 0.696974931154382 1 0.293811 0.297704 0.299551 0.180634 GeneID:8710,Genbank:NM_001040147.2,HGNC:HGNC:13902,MIM:603357 serpin family B member 7 GO:0004867,GO:0005615,GO:0005737,GO:0032914,GO:0032967,GO:0072126,GO:0090362 serine-type endopeptidase inhibitor activity|extracellular space|cytoplasm|positive regulation of transforming growth factor beta1 production|positive regulation of collagen biosynthetic process|positive regulation of glomerular mesangial cell proliferation|positive regulation of platelet-derived growth factor production SERPINB8 320.637634442978 340.305364707128 300.969904178827 0.884411282901302 -0.177210664394097 0.358673723000012 1 2.15716 2.4488 2.12766 1.96219 GeneID:5271,Genbank:XM_011526025.1,HGNC:HGNC:8952,MIM:601697 serpin family B member 8 GO:0004867,GO:0005615,GO:0005829,GO:0010951,GO:0070062,GO:0090136 serine-type endopeptidase inhibitor activity|extracellular space|cytosol|negative regulation of endopeptidase activity|extracellular exosome|epithelial cell-cell adhesion SERPINC1 1.7768481341111 1.61429302992691 1.93940323829528 1.20139479161543 0.264710314501509 1 1 0.0662655 0 0.0418141 0.0194741 GeneID:462,Genbank:NM_000488.3,HGNC:HGNC:775,MIM:107300 serpin family C member 1 hsa04610 Complement and coagulation cascades SERPIND1 7.4014568716165 11.8959838159236 2.90692992730943 0.244362296745756 -2.03290638949349 0.0761459231110421 0.94157495521624 0.170056 0.12738 0.0291121 0.0543546 GeneID:3053,Genbank:NM_000185.3,HGNC:HGNC:4838,MIM:142360 serpin family D member 1 GO:0004866,GO:0004867,GO:0005576,GO:0005615,GO:0005788,GO:0006935,GO:0007596,GO:0008201,GO:0043687,GO:0044267,GO:0070062 endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|endoplasmic reticulum lumen|chemotaxis|blood coagulation|heparin binding|post-translational protein modification|cellular protein metabolic process|extracellular exosome hsa04610 Complement and coagulation cascades SERPINE1 43930.898178606 47363.7728517084 40498.0235055036 0.855042178170629 -0.225932506775678 0.0767072471160688 0.94157495521624 493.592 500.664 472.471 395.047 GeneID:5054,Genbank:NM_000602.4,HGNC:HGNC:8583,MIM:173360 serpin family E member 1 hsa04066,hsa04115,hsa04218,hsa04371,hsa04390,hsa04610,hsa04933,hsa05142 HIF-1 signaling pathway|p53 signaling pathway|Cellular senescence|Apelin signaling pathway|Hippo signaling pathway|Complement and coagulation cascades|AGE-RAGE signaling pathway in diabetic complications|Chagas disease (American trypanosomiasis) SERPINE2 5420.71488935492 4794.58985523454 6046.8399234753 1.26117981017158 0.334773979670453 0.0120543172182142 0.448247539370507 67.6722 72.1667 92.9588 85.2287 GeneID:5270,Genbank:NM_001136528.1,HGNC:HGNC:8951,MIM:177010 serpin family E member 2 GO:0004867,GO:0005102,GO:0005539,GO:0005576,GO:0005615,GO:0005829,GO:0007596,GO:0008201,GO:0008285,GO:0010757,GO:0010766,GO:0010955,GO:0014067,GO:0021683,GO:0030195,GO:0030308,GO:0030334,GO:0031012,GO:0031091,GO:0031232,GO:0031594,GO:0032940,GO:0033363,GO:0042177,GO:0042628,GO:0045861,GO:0045879,GO:0048505,GO:0048711,GO:0050974,GO:0051966,GO:0060291,GO:0060384,GO:0061108,GO:0090331,GO:1903561 serine-type endopeptidase inhibitor activity|receptor binding|glycosaminoglycan binding|extracellular region|extracellular space|cytosol|blood coagulation|heparin binding|negative regulation of cell proliferation|negative regulation of plasminogen activation|negative regulation of sodium ion transport|negative regulation of protein processing|negative regulation of phosphatidylinositol 3-kinase signaling|cerebellar granular layer morphogenesis|negative regulation of blood coagulation|negative regulation of cell growth|regulation of cell migration|extracellular matrix|platelet alpha granule|extrinsic component of external side of plasma membrane|neuromuscular junction|secretion by cell|secretory granule organization|negative regulation of protein catabolic process|mating plug formation|negative regulation of proteolysis|negative regulation of smoothened signaling pathway|regulation of timing of cell differentiation|positive regulation of astrocyte differentiation|detection of mechanical stimulus involved in sensory perception|regulation of synaptic transmission, glutamatergic|long-term synaptic potentiation|innervation|seminal vesicle epithelium development|negative regulation of platelet aggregation|extracellular vesicle SERPINE3 2.4639289623622 2.98845468642911 1.93940323829528 0.648965248528718 -0.623786869540636 0.83446636833523 1 0.00318181 0.00907053 0.00916226 0.00284586 GeneID:647174,Genbank:XM_017020707.2,HGNC:HGNC:24774 serpin family E member 3 GO:0004867,GO:0005615 serine-type endopeptidase inhibitor activity|extracellular space SERPINF1 7.35386558295826 11.7999312665537 2.90779989936283 0.246425155679071 -2.02077855751934 0.0767482985724543 0.94157495521624 0.0474377 0.188719 0.021983 0.0411823 GeneID:5176,Genbank:NM_002615.6,HGNC:HGNC:8824,MIM:172860 serpin family F member 1 GO:0001822,GO:0004867,GO:0005576,GO:0005604,GO:0005615,GO:0007275,GO:0007568,GO:0007614,GO:0008283,GO:0010447,GO:0010596,GO:0010629,GO:0010976,GO:0016525,GO:0042470,GO:0042698,GO:0043203,GO:0046685,GO:0048471,GO:0050728,GO:0050769,GO:0060041,GO:0060770,GO:0070062,GO:0071279,GO:0071300,GO:0071333,GO:0071549,GO:1901215 kidney development|serine-type endopeptidase inhibitor activity|extracellular region|basement membrane|extracellular space|multicellular organism development|aging|short-term memory|cell proliferation|response to acidic pH|negative regulation of endothelial cell migration|negative regulation of gene expression|positive regulation of neuron projection development|negative regulation of angiogenesis|melanosome|ovulation cycle|axon hillock|response to arsenic-containing substance|perinuclear region of cytoplasm|negative regulation of inflammatory response|positive regulation of neurogenesis|retina development in camera-type eye|negative regulation of epithelial cell proliferation involved in prostate gland development|extracellular exosome|cellular response to cobalt ion|cellular response to retinoic acid|cellular response to glucose stimulus|cellular response to dexamethasone stimulus|negative regulation of neuron death hsa04310 Wnt signaling pathway SERPINF2 5.99524367087362 6.65908587355536 5.33140146819188 0.800620621122189 -0.320809320021779 0.855023283236517 1 0.0891828 0.108562 0.0990443 0.0771427 GeneID:5345,Genbank:XM_017024765.1,HGNC:HGNC:9075,MIM:613168 serpin family F member 2 GO:0002020,GO:0002034,GO:0002576,GO:0004866,GO:0004867,GO:0005576,GO:0005577,GO:0005615,GO:0006953,GO:0009986,GO:0010033,GO:0010757,GO:0030199,GO:0031093,GO:0032967,GO:0042730,GO:0042803,GO:0045597,GO:0045944,GO:0046330,GO:0048514,GO:0048661,GO:0051496,GO:0051918,GO:0070062,GO:0070374,GO:0071636,GO:0072562,GO:2000049 protease binding|regulation of blood vessel diameter by renin-angiotensin|platelet degranulation|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|fibrinogen complex|extracellular space|acute-phase response|cell surface|response to organic substance|negative regulation of plasminogen activation|collagen fibril organization|platelet alpha granule lumen|positive regulation of collagen biosynthetic process|fibrinolysis|protein homodimerization activity|positive regulation of cell differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|blood vessel morphogenesis|positive regulation of smooth muscle cell proliferation|positive regulation of stress fiber assembly|negative regulation of fibrinolysis|extracellular exosome|positive regulation of ERK1 and ERK2 cascade|positive regulation of transforming growth factor beta production|blood microparticle|positive regulation of cell-cell adhesion mediated by cadherin hsa04610 Complement and coagulation cascades SERPING1 2.66994222788783 0.490071401957362 4.8498130538183 9.89613561299024 3.30686527061015 0.320228379778398 1 0 0.0155335 0.129839 0.0151923 GeneID:710,Genbank:NM_000062.2,HGNC:HGNC:1228,MIM:606860 serpin family G member 1 hsa04610,hsa05133 Complement and coagulation cascades|Pertussis SERPINH1 1380.2513178675 1346.9329529326 1413.56968280241 1.04947293755396 0.0696649647624359 0.658417339553824 1 18.2175 19.745 19.1072 21.1319 GeneID:871,Genbank:NM_001207014.1,HGNC:HGNC:1546,MIM:600943 serpin family H member 1 SERPINI1 133.97918297252 124.994582461887 142.963783483152 1.14375983876537 0.19378415369347 0.460966990126365 1 2.39847 2.19649 2.52487 2.62998 GeneID:5274,Genbank:NM_001122752.1,HGNC:HGNC:8943,MIM:602445 serpin family I member 1 GO:0004867,GO:0005615,GO:0007417,GO:0007422,GO:0010976,GO:0030155,GO:0034774,GO:0043025,GO:0043204,GO:0060205,GO:0070062 serine-type endopeptidase inhibitor activity|extracellular space|central nervous system development|peripheral nervous system development|positive regulation of neuron projection development|regulation of cell adhesion|secretory granule lumen|neuronal cell body|perikaryon|cytoplasmic vesicle lumen|extracellular exosome SERPINI2 0.97013660517434 0 1.94027321034868 Inf Inf 0.496193947515089 1 0 0 0.0876745 0 GeneID:5276,Genbank:NM_006217.4,HGNC:HGNC:8945,MIM:605587 serpin family I member 2 GO:0004867,GO:0005615,GO:0006928,GO:0070062 serine-type endopeptidase inhibitor activity|extracellular space|movement of cell or subcellular component|extracellular exosome SERTAD1 380.473425653903 390.705266868728 370.241584439079 0.947623735421707 -0.0776137602324568 0.65802076880855 1 14.6397 16.5655 15.0519 15.3982 GeneID:29950,Genbank:NM_013376.3,HGNC:HGNC:17932,MIM:617850 SERTA domain containing 1 SERTAD2 471.941546675665 511.567555706 432.315537645329 0.845080054087289 -0.242840081108837 0.168059972143035 1 3.41762 3.58584 3.2738 2.70287 GeneID:9792,Genbank:XM_005264669.3,HGNC:HGNC:30784,MIM:617851 SERTA domain containing 2 GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0030308,GO:0045893 transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|negative regulation of cell growth|positive regulation of transcription, DNA-templated SERTAD3 417.67739917208 406.482587279879 428.872211064282 1.05508138475065 0.0773542869397146 0.672842548516217 1 8.20957 7.66538 8.25768 8.92528 GeneID:29946,Genbank:NM_203344.2,HGNC:HGNC:17931,MIM:612125 SERTA domain containing 3 GO:0005634,GO:0005730,GO:0006351,GO:0006355,GO:0030308,GO:0045893 nucleus|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of cell growth|positive regulation of transcription, DNA-templated SERTAD4 355.378516806668 333.184616396085 377.57241721725 1.13322283994168 0.180431584430601 0.364946132004611 1 2.41761 2.48927 3.28186 2.34529 GeneID:56256,Genbank:NM_001354173.1,HGNC:HGNC:25236 SERTA domain containing 4 GO:0005634 nucleus SERTM2 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0.00890045 0 0.00857204 0.00800659 GeneID:401613,Genbank:NM_001354473.1,HGNC:HGNC:48576 serine rich and transmembrane domain containing 2 SESN1 148.88907195775 159.664173486166 138.113970429334 0.865027935908871 -0.209181369830029 0.418020134469557 1 1.9233 1.91462 1.63445 1.71236 GeneID:27244,Genbank:NM_014454.2,HGNC:HGNC:21595,MIM:606103 sestrin 1 GO:0001650,GO:0005634,GO:0005737,GO:0005829,GO:0034198,GO:0042149,GO:0051920,GO:0070728,GO:0072593,GO:0098869,GO:1901031,GO:1904262 fibrillar center|nucleus|cytoplasm|cytosol|cellular response to amino acid starvation|cellular response to glucose starvation|peroxiredoxin activity|leucine binding|reactive oxygen species metabolic process|cellular oxidant detoxification|regulation of response to reactive oxygen species|negative regulation of TORC1 signaling hsa04115,hsa04211 p53 signaling pathway|Longevity regulating pathway SESN2 427.98897375023 450.857553793935 405.120393706525 0.89855518732572 -0.154320981206583 0.391350390877519 1 5.62852 5.65593 4.91267 5.45833 GeneID:83667,Genbank:NM_031459.4,HGNC:HGNC:20746,MIM:607767 sestrin 2 GO:0001932,GO:0005092,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006635,GO:0009749,GO:0016239,GO:0016684,GO:0030308,GO:0030330,GO:0031588,GO:0031932,GO:0032042,GO:0032542,GO:0032868,GO:0034198,GO:0034599,GO:0036091,GO:0042149,GO:0043491,GO:0046323,GO:0070328,GO:0070728,GO:0071230,GO:0071233,GO:0072593,GO:0090526,GO:0098869,GO:1900182,GO:1901031,GO:1902010,GO:1904262,GO:1904504,GO:1990253,GO:2000479 regulation of protein phosphorylation|GDP-dissociation inhibitor activity|nucleus|cytoplasm|mitochondrion|cytosol|fatty acid beta-oxidation|response to glucose|positive regulation of macroautophagy|oxidoreductase activity, acting on peroxide as acceptor|negative regulation of cell growth|DNA damage response, signal transduction by p53 class mediator|nucleotide-activated protein kinase complex|TORC2 complex|mitochondrial DNA metabolic process|sulfiredoxin activity|response to insulin|cellular response to amino acid starvation|cellular response to oxidative stress|positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress|cellular response to glucose starvation|protein kinase B signaling|glucose import|triglyceride homeostasis|leucine binding|cellular response to amino acid stimulus|cellular response to leucine|reactive oxygen species metabolic process|regulation of gluconeogenesis involved in cellular glucose homeostasis|cellular oxidant detoxification|positive regulation of protein localization to nucleus|regulation of response to reactive oxygen species|negative regulation of translation in response to endoplasmic reticulum stress|negative regulation of TORC1 signaling|positive regulation of lipophagy|cellular response to leucine starvation|regulation of cAMP-dependent protein kinase activity hsa04115,hsa04150,hsa04211 p53 signaling pathway|mTOR signaling pathway|Longevity regulating pathway SESN3 553.66458452178 521.40618436387 585.92298467969 1.12373616242111 0.1683033506413 0.30645649083431 1 2.48701 2.20002 2.69777 2.50947 GeneID:143686,Genbank:NM_001271594.1,HGNC:HGNC:23060,MIM:607768 sestrin 3 GO:0005634,GO:0005737,GO:0016491,GO:0031932,GO:0032868,GO:0034198,GO:0038203,GO:0042149,GO:0042593,GO:0046626,GO:0051896,GO:0071230,GO:1901031,GO:1904262 nucleus|cytoplasm|oxidoreductase activity|TORC2 complex|response to insulin|cellular response to amino acid starvation|TORC2 signaling|cellular response to glucose starvation|glucose homeostasis|regulation of insulin receptor signaling pathway|regulation of protein kinase B signaling|cellular response to amino acid stimulus|regulation of response to reactive oxygen species|negative regulation of TORC1 signaling hsa04115,hsa04211 p53 signaling pathway|Longevity regulating pathway SESTD1 234.376834022542 266.151712533259 202.601955511826 0.761227322505047 -0.39360075012367 0.0702090240960526 0.92021045003939 0.922817 0.882893 0.794739 0.49701 GeneID:91404,Genbank:NM_178123.4,HGNC:HGNC:18379 SEC14 and spectrin domain containing 1 GO:0005546,GO:0010314,GO:0032266,GO:0043325,GO:0045111,GO:0070273,GO:0070300,GO:0080025,GO:1904878 phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-3,4-bisphosphate binding|intermediate filament cytoskeleton|phosphatidylinositol-4-phosphate binding|phosphatidic acid binding|phosphatidylinositol-3,5-bisphosphate binding|negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel SET 7999.67616808276 8191.47412648079 7807.87820968474 0.953171320464043 -0.0691925512974528 0.606985053536012 1 65.8814 64.3605 64.7766 60.4429 GeneID:6418,Genbank:XM_017015015.1,HGNC:HGNC:10760,MIM:600960 SET nuclear proto-oncogene SETBP1 101.324461611591 90.6807926706184 111.968130552564 1.23475024043148 0.304219249639034 0.311810621092487 1 0.0905506 0.097655 0.141217 0.0953164 GeneID:26040,Genbank:XM_024451149.1,HGNC:HGNC:15573,MIM:611060 SET binding protein 1 SETD1A 1020.21809375142 996.528193883103 1043.90799361974 1.04754486629426 0.067012035804394 0.677856532983733 1 4.77786 5.01845 5.42312 5.09856 GeneID:9739,Genbank:XM_017023909.1,HGNC:HGNC:29010,MIM:611052 SET domain containing 1A GO:0000790,GO:0003723,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0008013,GO:0008134,GO:0016607,GO:0018024,GO:0035097,GO:0042800,GO:0045652,GO:0048188,GO:1902036,GO:1902275 nuclear chromatin|RNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|beta-catenin binding|transcription factor binding|nuclear speck|histone-lysine N-methyltransferase activity|histone methyltransferase complex|histone methyltransferase activity (H3-K4 specific)|regulation of megakaryocyte differentiation|Set1C/COMPASS complex|regulation of hematopoietic stem cell differentiation|regulation of chromatin organization hsa00310 Lysine degradation SETD1B 596.43903944316 618.554974810158 574.323104076161 0.928491609419886 -0.107039221994319 0.520023457263127 1 2.54395 2.50152 2.62447 2.18541 GeneID:23067,Genbank:XM_006719296.3,HGNC:HGNC:29187,MIM:611055 SET domain containing 1B GO:0003723,GO:0005654,GO:0005694,GO:0005829,GO:0006351,GO:0006355,GO:0016607,GO:0018024,GO:0035097,GO:0048188,GO:0051568 RNA binding|nucleoplasm|chromosome|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck|histone-lysine N-methyltransferase activity|histone methyltransferase complex|Set1C/COMPASS complex|histone H3-K4 methylation hsa00310 Lysine degradation SETD2 792.68652611098 789.893601048184 795.479451173775 1.00707164878685 0.0101663285009167 0.978898072871297 1 2.54547 2.57191 3.49091 1.76827 GeneID:29072,Genbank:NM_001349370.1,HGNC:HGNC:18420,MIM:612778 SET domain containing 2 GO:0001525,GO:0001763,GO:0001843,GO:0005634,GO:0005654,GO:0005694,GO:0006298,GO:0006355,GO:0006368,GO:0010569,GO:0010793,GO:0016279,GO:0018023,GO:0018024,GO:0018026,GO:0030900,GO:0032465,GO:0032727,GO:0034340,GO:0034728,GO:0035441,GO:0035987,GO:0043014,GO:0046872,GO:0046975,GO:0048332,GO:0048701,GO:0048863,GO:0048864,GO:0051607,GO:0060039,GO:0060669,GO:0060977,GO:0097198,GO:0097676,GO:1902850,GO:1905634 angiogenesis|morphogenesis of a branching structure|neural tube closure|nucleus|nucleoplasm|chromosome|mismatch repair|regulation of transcription, DNA-templated|transcription elongation from RNA polymerase II promoter|regulation of double-strand break repair via homologous recombination|regulation of mRNA export from nucleus|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|forebrain development|regulation of cytokinesis|positive regulation of interferon-alpha production|response to type I interferon|nucleosome organization|cell migration involved in vasculogenesis|endodermal cell differentiation|alpha-tubulin binding|metal ion binding|histone methyltransferase activity (H3-K36 specific)|mesoderm morphogenesis|embryonic cranial skeleton morphogenesis|stem cell differentiation|stem cell development|defense response to virus|pericardium development|embryonic placenta morphogenesis|coronary vasculature morphogenesis|histone H3-K36 trimethylation|histone H3-K36 dimethylation|microtubule cytoskeleton organization involved in mitosis|regulation of protein localization to chromatin hsa00310 Lysine degradation SETD3 1166.15264268782 1201.63270358065 1130.672581795 0.940946912002142 -0.0878147661437401 0.559433149775792 1 8.29585 8.4106 8.56224 7.40118 GeneID:84193,Genbank:XM_011537233.2,HGNC:HGNC:20493,MIM:615671 SET domain containing 3 GO:0000790,GO:0001102,GO:0003713,GO:0005654,GO:0006351,GO:0010452,GO:0018023,GO:0018024,GO:0018026,GO:0018027,GO:0042800,GO:0045893,GO:0045944,GO:0046975,GO:0051149,GO:0051568 nuclear chromatin|RNA polymerase II activating transcription factor binding|transcription coactivator activity|nucleoplasm|transcription, DNA-templated|histone H3-K36 methylation|peptidyl-lysine trimethylation|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|histone methyltransferase activity (H3-K4 specific)|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|histone methyltransferase activity (H3-K36 specific)|positive regulation of muscle cell differentiation|histone H3-K4 methylation hsa00310 Lysine degradation SETD4 175.175758973621 188.020671214792 162.33084673245 0.863367020677239 -0.211954109818031 0.375288020310156 1 1.41392 1.69794 1.16997 1.43498 GeneID:54093,Genbank:XM_011529642.2,HGNC:HGNC:1258 SET domain containing 4 GO:0005730,GO:0016279,GO:0018023,GO:0018026,GO:0042254 nucleolus|protein-lysine N-methyltransferase activity|peptidyl-lysine trimethylation|peptidyl-lysine monomethylation|ribosome biogenesis SETD5 2723.21920133203 2783.15866022078 2663.27974244327 0.956927027017569 -0.0635191824789726 0.653179756740875 1 5.42166 5.40087 5.7265 4.58567 GeneID:55209,Genbank:NM_001349451.1,HGNC:HGNC:25566,MIM:615743 SET domain containing 5 GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0016569,GO:0016593,GO:0035065,GO:1902275 nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|covalent chromatin modification|Cdc73/Paf1 complex|regulation of histone acetylation|regulation of chromatin organization SETD6 283.012108252973 298.486616407337 267.537600098608 0.89631355441916 -0.157924581050975 0.43269382644343 1 2.98247 3.349 3.08754 2.38541 GeneID:79918,Genbank:NM_001160305.2,HGNC:HGNC:26116,MIM:616424 SET domain containing 6 GO:0005634,GO:0005654,GO:0005829,GO:0016279,GO:0018026,GO:0019827,GO:0032088,GO:0034968,GO:0048863,GO:0050727,GO:0051059 nucleus|nucleoplasm|cytosol|protein-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|stem cell population maintenance|negative regulation of NF-kappaB transcription factor activity|histone lysine methylation|stem cell differentiation|regulation of inflammatory response|NF-kappaB binding SETD7 1227.86978637704 1012.83176931408 1442.90780344 1.4246273143833 0.510584556461283 0.0352255965487803 0.734506941207039 5.26396 4.26829 7.77111 5.84012 GeneID:80854,Genbank:NM_001306199.1,HGNC:HGNC:30412,MIM:606594 SET domain containing lysine methyltransferase 7 GO:0002039,GO:0003682,GO:0005654,GO:0005694,GO:0005730,GO:0006325,GO:0006351,GO:0006974,GO:0016279,GO:0018024,GO:0018026,GO:0018027,GO:0045471,GO:0045893,GO:0051570,GO:0070828 p53 binding|chromatin binding|nucleoplasm|chromosome|nucleolus|chromatin organization|transcription, DNA-templated|cellular response to DNA damage stimulus|protein-lysine N-methyltransferase activity|histone-lysine N-methyltransferase activity|peptidyl-lysine monomethylation|peptidyl-lysine dimethylation|response to ethanol|positive regulation of transcription, DNA-templated|regulation of histone H3-K9 methylation|heterochromatin organization hsa00310,hsa04068 Lysine degradation|FoxO signaling pathway SETD9 134.970083986094 130.865630630267 139.074537341921 1.06272775114534 0.0877720555912699 0.732258533796836 1 0.351714 0.262238 0.288963 0.370365 GeneID:133383,Genbank:NM_001171990.2,HGNC:HGNC:28508 SET domain containing 9 GO:0005654,GO:0016278,GO:1901796 nucleoplasm|lysine N-methyltransferase activity|regulation of signal transduction by p53 class mediator SETDB1 732.576413926551 802.241438646488 662.911389206613 0.826324043202072 -0.275220449024204 0.0884553418003717 0.97367749434691 4.58625 4.61181 3.52731 4.12956 GeneID:9869,Genbank:XM_017002953.1,HGNC:HGNC:10761,MIM:604396 SET domain bifurcated 1 GO:0003677,GO:0003682,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0005886,GO:0006351,GO:0007265,GO:0008270,GO:0018024,GO:0033273,GO:0043231,GO:0045471,GO:0090309,GO:1990841 DNA binding|chromatin binding|nucleus|nucleoplasm|chromosome|cytosol|plasma membrane|transcription, DNA-templated|Ras protein signal transduction|zinc ion binding|histone-lysine N-methyltransferase activity|response to vitamin|intracellular membrane-bounded organelle|response to ethanol|positive regulation of methylation-dependent chromatin silencing|promoter-specific chromatin binding hsa00310,hsa04550 Lysine degradation|Signaling pathways regulating pluripotency of stem cells SETDB2 19.2232848784847 20.025283895351 18.4212858616183 0.919901358596714 -0.120448926210131 0.894352845505827 1 0.234302 0.293282 0.255005 0.120508 GeneID:83852,Genbank:NM_031915.2,HGNC:HGNC:20263,MIM:607865 SET domain bifurcated 2 GO:0000278,GO:0001947,GO:0003677,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0007059,GO:0008270,GO:0018024,GO:0045892,GO:0046974,GO:0051301,GO:0051567,GO:0070986 mitotic cell cycle|heart looping|DNA binding|nucleus|nucleoplasm|chromosome|cytosol|chromosome segregation|zinc ion binding|histone-lysine N-methyltransferase activity|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K9 specific)|cell division|histone H3-K9 methylation|left/right axis specification hsa00310 Lysine degradation SETMAR 225.191210525323 250.229296297198 200.153124753448 0.799878861968765 -0.322146567974812 0.148831944777009 1 1.19093 1.05278 0.847855 0.91861 GeneID:6419,Genbank:NM_006515.3,HGNC:HGNC:10762,MIM:609834 SET domain and mariner transposase fusion gene hsa00310 Lysine degradation SETSIP 3.4630818042492 4.01662376502878 2.90953984346962 0.724374502984791 -0.465192328644523 0.844923807399798 1 0.0616929 0.177789 0.148252 0.0274522 GeneID:646817,Genbank:NM_001287737.1,HGNC:HGNC:42937 SET-like protein GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0005811,GO:0006334,GO:0006351,GO:0045446,GO:0045944 chromatin binding|nucleus|nucleoplasm|cytoplasm|lipid droplet|nucleosome assembly|transcription, DNA-templated|endothelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter SETX 280.943083709342 280.728376077286 281.157791341399 1.00152964680704 0.0022051277591511 0.989935182906998 1 0.736768 0.635157 0.940338 0.518839 GeneID:23064,Genbank:NM_015046.6,HGNC:HGNC:445,MIM:608465 senataxin GO:0000165,GO:0000228,GO:0000781,GO:0001147,GO:0003677,GO:0003678,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006302,GO:0006310,GO:0006353,GO:0006369,GO:0006376,GO:0006396,GO:0006974,GO:0007283,GO:0007623,GO:0008543,GO:0010976,GO:0016604,GO:0030424,GO:0030426,GO:0033120,GO:0034599,GO:0042802,GO:0043066,GO:0043491,GO:0044344,GO:0045171,GO:0045944,GO:0060566,GO:0070301,GO:0071300,GO:2000144,GO:2000806 MAPK cascade|nuclear chromosome|chromosome, telomeric region|transcription termination site sequence-specific DNA binding|DNA binding|DNA helicase activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|double-strand break repair|DNA recombination|DNA-templated transcription, termination|termination of RNA polymerase II transcription|mRNA splice site selection|RNA processing|cellular response to DNA damage stimulus|spermatogenesis|circadian rhythm|fibroblast growth factor receptor signaling pathway|positive regulation of neuron projection development|nuclear body|axon|growth cone|positive regulation of RNA splicing|cellular response to oxidative stress|identical protein binding|negative regulation of apoptotic process|protein kinase B signaling|cellular response to fibroblast growth factor stimulus|intercellular bridge|positive regulation of transcription from RNA polymerase II promoter|positive regulation of DNA-templated transcription, termination|cellular response to hydrogen peroxide|cellular response to retinoic acid|positive regulation of DNA-templated transcription, initiation|positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled SEZ6 1.21430233409962 0.490071401957362 1.93853326624189 3.95561393400904 1.98390162663545 0.683537482026705 1 0 0.00861116 0.0183212 0 GeneID:124925,Genbank:NM_001290202.1,HGNC:HGNC:15955,MIM:616666 seizure related 6 homolog GO:0005615,GO:0005783,GO:0005886,GO:0008344,GO:0016021,GO:0021680,GO:0043025,GO:0043197,GO:0043198,GO:0048471,GO:0060074,GO:0060079,GO:0090036,GO:0097440,GO:1900006,GO:2000171 extracellular space|endoplasmic reticulum|plasma membrane|adult locomotory behavior|integral component of membrane|cerebellar Purkinje cell layer development|neuronal cell body|dendritic spine|dendritic shaft|perinuclear region of cytoplasm|synapse maturation|excitatory postsynaptic potential|regulation of protein kinase C signaling|apical dendrite|positive regulation of dendrite development|negative regulation of dendrite development SEZ6L2 471.038709722132 432.754337886836 509.323081557427 1.17693350930803 0.235032817826503 0.192382231588204 1 3.6572 3.8327 4.31667 4.70676 GeneID:26470,Genbank:XM_017023135.2,HGNC:HGNC:30844,MIM:616667 seizure related 6 homolog like 2 GO:0005789,GO:0005886,GO:0016021 endoplasmic reticulum membrane|plasma membrane|integral component of membrane SF1 5192.34953971858 5489.47928188961 4895.21979754756 0.891745746030488 -0.165295666387995 0.20725401099753 1 30.5049 31.5746 29.3603 27.5634 GeneID:7536,Genbank:NM_001346409.1,HGNC:HGNC:12950,MIM:601516 splicing factor 1 GO:0000245,GO:0000389,GO:0000398,GO:0003714,GO:0003723,GO:0005634,GO:0005654,GO:0005681,GO:0005840,GO:0006351,GO:0006355,GO:0008270,GO:0016604,GO:0030238,GO:0030575,GO:0033327,GO:0042802,GO:0045131,GO:0048662,GO:0050810 spliceosomal complex assembly|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|transcription corepressor activity|RNA binding|nucleus|nucleoplasm|spliceosomal complex|ribosome|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|nuclear body|male sex determination|nuclear body organization|Leydig cell differentiation|identical protein binding|pre-mRNA branch point binding|negative regulation of smooth muscle cell proliferation|regulation of steroid biosynthetic process SF3A1 2714.88307643899 2795.37426165185 2634.39189122613 0.942411156661867 -0.085571476383808 0.526549092559877 1 17.2424 17.7274 16.8337 16.7902 GeneID:10291,Genbank:NM_005877.5,HGNC:HGNC:10765,MIM:605595 splicing factor 3a subunit 1 GO:0000381,GO:0000389,GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0005684,GO:0005686,GO:0006397,GO:0016607,GO:0071004,GO:0071013 regulation of alternative mRNA splicing, via spliceosome|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|U2-type spliceosomal complex|U2 snRNP|mRNA processing|nuclear speck|U2-type prespliceosome|catalytic step 2 spliceosome hsa03040 Spliceosome SF3A2 1578.31699623444 1619.43801038279 1537.19598208608 0.949215698427829 -0.0751921344137642 0.614864060988401 1 33.6953 38.0086 34.5514 35.3304 GeneID:8175,Genbank:NM_007165.4,HGNC:HGNC:10766,MIM:600796 splicing factor 3a subunit 2 GO:0000389,GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0005686,GO:0006397,GO:0008270,GO:0008380,GO:0010976,GO:0016607,GO:0030532,GO:0071004,GO:0071013 mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|U2 snRNP|mRNA processing|zinc ion binding|RNA splicing|positive regulation of neuron projection development|nuclear speck|small nuclear ribonucleoprotein complex|U2-type prespliceosome|catalytic step 2 spliceosome hsa03040 Spliceosome SF3A3 3005.33333611402 2979.33704047947 3031.32963174857 1.01745106060935 0.0249594025365324 0.84390657505393 1 31.7165 30.5233 32.3371 31.442 GeneID:10946,Genbank:NM_001320830.1,HGNC:HGNC:10767,MIM:605596 splicing factor 3a subunit 3 GO:0000375,GO:0000389,GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0006397,GO:0008270,GO:0008380,GO:0016607,GO:0071013 RNA splicing, via transesterification reactions|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|mRNA processing|zinc ion binding|RNA splicing|nuclear speck|catalytic step 2 spliceosome hsa03040 Spliceosome SF3B1 3019.23872376558 3254.55489327222 2783.92255425894 0.855392717453876 -0.225341170275293 0.275778578665648 1 20.0053 16.6735 17.5911 14.2262 GeneID:23451,Genbank:NM_012433.3,HGNC:HGNC:10768,MIM:605590 splicing factor 3b subunit 1 GO:0000245,GO:0000375,GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005681,GO:0005686,GO:0005689,GO:0016607,GO:0034693,GO:0045815,GO:0071004,GO:0071013 spliceosomal complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|spliceosomal complex|U2 snRNP|U12-type spliceosomal complex|nuclear speck|U11/U12 snRNP|positive regulation of gene expression, epigenetic|U2-type prespliceosome|catalytic step 2 spliceosome hsa03040 Spliceosome SF3B2 6024.76125938395 5523.71561944087 6525.80689932702 1.18141616059293 0.240517251835249 0.0700079070563138 0.92021045003939 50.0894 51.1254 59.4955 60.6553 GeneID:10992,Genbank:NM_006842.2,HGNC:HGNC:10769,MIM:605591 splicing factor 3b subunit 2 GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0005684,GO:0005686,GO:0005689,GO:0006397,GO:0008380,GO:0016032,GO:0016607,GO:0071011,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|U2-type spliceosomal complex|U2 snRNP|U12-type spliceosomal complex|mRNA processing|RNA splicing|viral process|nuclear speck|precatalytic spliceosome|catalytic step 2 spliceosome hsa03040 Spliceosome SF3B3 7690.80470685089 7883.93219546993 7497.67721823185 0.951007318726051 -0.0724716511210279 0.575939283073211 1 28.8639 29.8009 28.6491 27.6104 GeneID:23450,Genbank:NM_012426.4,HGNC:HGNC:10770,MIM:605592 splicing factor 3b subunit 3 GO:0000375,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005681,GO:0005689,GO:0005730,GO:0006397,GO:0006461,GO:0008380,GO:0030532,GO:0032403,GO:0042177,GO:0071013 RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|nucleolus|mRNA processing|protein complex assembly|RNA splicing|small nuclear ribonucleoprotein complex|protein complex binding|negative regulation of protein catabolic process|catalytic step 2 spliceosome hsa03040 Spliceosome SF3B4 2703.49771661634 2701.95495432333 2705.04047890934 1.00114196003937 0.00164656011159626 1 1 51.725 52.0575 50.8985 55.9826 GeneID:10262,Genbank:NM_005850.4,HGNC:HGNC:10771,MIM:605593 splicing factor 3b subunit 4 GO:0000375,GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0005689,GO:0006397,GO:0008380,GO:0048026 RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|U12-type spliceosomal complex|mRNA processing|RNA splicing|positive regulation of mRNA splicing, via spliceosome hsa03040 Spliceosome SF3B5 3201.63887980316 3230.22417231632 3173.05358729 0.982301356817188 -0.0257624030472897 0.870306078591717 1 273.281 278.342 250.671 294.179 GeneID:83443,Genbank:NM_031287.2,HGNC:HGNC:21083,MIM:617847 splicing factor 3b subunit 5 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005686,GO:0005689,GO:0071011 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|U2 snRNP|U12-type spliceosomal complex|precatalytic spliceosome hsa03040 Spliceosome SF3B6 1781.14910892167 1825.04915778995 1737.24906005338 0.951891653240242 -0.0711307232748795 0.636370298792277 1 78.4077 76.1416 67.7527 76.5039 GeneID:51639,Genbank:NM_016047.3,HGNC:HGNC:30096,MIM:607835 splicing factor 3b subunit 6 GO:0000398,GO:0001825,GO:0003723,GO:0005654,GO:0005684,GO:0005686,GO:0005689,GO:0071011,GO:0071013 mRNA splicing, via spliceosome|blastocyst formation|RNA binding|nucleoplasm|U2-type spliceosomal complex|U2 snRNP|U12-type spliceosomal complex|precatalytic spliceosome|catalytic step 2 spliceosome hsa03040 Spliceosome SFI1 279.163349781783 272.859841682354 285.466857881212 1.0462032672933 0.0651631806728852 0.840161484603854 1 1.45726 1.89732 2.02555 1.56481 GeneID:9814,Genbank:NM_001007467.2,HGNC:HGNC:29064,MIM:612765 SFI1 centrin binding protein GO:0000086,GO:0005813,GO:0005814,GO:0005829,GO:0010389,GO:0010923,GO:0019902,GO:0097711 G2/M transition of mitotic cell cycle|centrosome|centriole|cytosol|regulation of G2/M transition of mitotic cell cycle|negative regulation of phosphatase activity|phosphatase binding|ciliary basal body-plasma membrane docking SFMBT1 856.379949387074 940.669862715072 772.090036059076 0.82078746929404 -0.284919388948903 0.068412008215946 0.918202374283561 3.73075 3.84563 3.52998 2.63864 GeneID:51460,Genbank:XM_006713204.3,HGNC:HGNC:20255,MIM:607319 Scm like with four mbt domains 1 GO:0003714,GO:0005634,GO:0005654,GO:0006351,GO:0007283,GO:0016569,GO:0030154,GO:0042393,GO:0045892,GO:0048635 transcription corepressor activity|nucleus|nucleoplasm|transcription, DNA-templated|spermatogenesis|covalent chromatin modification|cell differentiation|histone binding|negative regulation of transcription, DNA-templated|negative regulation of muscle organ development SFMBT2 213.732531992086 234.086365997929 193.378697986242 0.826099790826573 -0.27561202869688 0.219296196966883 1 1.05415 1.00538 0.931537 0.806165 GeneID:57713,Genbank:NM_001029880.2,HGNC:HGNC:20256,MIM:615392 Scm like with four mbt domains 2 GO:0005634,GO:0006355,GO:0010629,GO:0016235,GO:0016607,GO:0042393,GO:0043231 nucleus|regulation of transcription, DNA-templated|negative regulation of gene expression|aggresome|nuclear speck|histone binding|intracellular membrane-bounded organelle SFN 32.4853694431586 40.7425529465071 24.22818593981 0.594665385147081 -0.749849994505445 0.128432051324149 1 1.11081 1.29767 0.669531 0.867804 GeneID:2810,Genbank:NM_006142.4,HGNC:HGNC:10773,MIM:601290 stratifin GO:0000079,GO:0001836,GO:0003334,GO:0005615,GO:0005634,GO:0005739,GO:0005829,GO:0006469,GO:0006977,GO:0007165,GO:0008426,GO:0008630,GO:0010482,GO:0010839,GO:0019901,GO:0019904,GO:0030307,GO:0030659,GO:0031424,GO:0042802,GO:0043154,GO:0045296,GO:0045606,GO:0046827,GO:0051219,GO:0061024,GO:0061436,GO:0070062,GO:1900740 regulation of cyclin-dependent protein serine/threonine kinase activity|release of cytochrome c from mitochondria|keratinocyte development|extracellular space|nucleus|mitochondrion|cytosol|negative regulation of protein kinase activity|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|signal transduction|protein kinase C inhibitor activity|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of epidermal cell division|negative regulation of keratinocyte proliferation|protein kinase binding|protein domain specific binding|positive regulation of cell growth|cytoplasmic vesicle membrane|keratinization|identical protein binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|cadherin binding|positive regulation of epidermal cell differentiation|positive regulation of protein export from nucleus|phosphoprotein binding|membrane organization|establishment of skin barrier|extracellular exosome|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway hsa04110,hsa04115,hsa04960 Cell cycle|p53 signaling pathway|Aldosterone-regulated sodium reabsorption SFPQ 6216.69120746331 6348.72456329059 6084.65785163603 0.958406336733927 -0.0612906480039968 0.654908372366629 1 27.8224 27.2649 28.0252 25.0498 GeneID:6421,Genbank:XM_017002053.2,HGNC:HGNC:10774,MIM:605199 splicing factor proline and glutamine rich SFR1 148.133437888808 150.3822428143 145.884632963316 0.97009214807005 -0.0438063009386315 0.847444614391805 1 2.15087 3.10158 2.66206 2.33471 GeneID:119392,Genbank:NM_145247.4,HGNC:HGNC:29574,MIM:616527 SWI5 dependent homologous recombination repair protein 1 GO:0000724,GO:0005634,GO:0006351,GO:0030374,GO:0032798,GO:0045893,GO:0071391 double-strand break repair via homologous recombination|nucleus|transcription, DNA-templated|ligand-dependent nuclear receptor transcription coactivator activity|Swi5-Sfr1 complex|positive regulation of transcription, DNA-templated|cellular response to estrogen stimulus SFRP1 2713.65770475423 2419.91904317359 3007.39636633486 1.24276734579965 0.313556239691295 0.0379459929660439 0.745170033530679 23.5624 24.7007 34.3151 26.6024 GeneID:6422,Genbank:NM_003012.4,HGNC:HGNC:10776,MIM:604156 secreted frizzled related protein 1 GO:0001649,GO:0001657,GO:0001954,GO:0002244,GO:0004197,GO:0004930,GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0005622,GO:0005829,GO:0005886,GO:0008144,GO:0008201,GO:0008284,GO:0008285,GO:0008584,GO:0008585,GO:0009267,GO:0009950,GO:0009986,GO:0010564,GO:0010629,GO:0010719,GO:0010975,GO:0014034,GO:0014070,GO:0016021,GO:0017147,GO:0022601,GO:0030177,GO:0030178,GO:0030279,GO:0030307,GO:0030308,GO:0030336,GO:0030514,GO:0031012,GO:0033689,GO:0035019,GO:0042493,GO:0042802,GO:0042813,GO:0043065,GO:0043066,GO:0043508,GO:0043547,GO:0044344,GO:0044345,GO:0045578,GO:0045600,GO:0045668,GO:0045671,GO:0045765,GO:0045880,GO:0045892,GO:0045893,GO:0046676,GO:0046851,GO:0048147,GO:0048546,GO:0050679,GO:0050680,GO:0050732,GO:0051496,GO:0051894,GO:0060070,GO:0060218,GO:0060346,GO:0060527,GO:0060687,GO:0060766,GO:0070062,GO:0071305,GO:0071347,GO:0071356,GO:0071363,GO:0071380,GO:0071391,GO:0071392,GO:0071456,GO:0071481,GO:0071504,GO:0071542,GO:0071560,GO:0071773,GO:0090090,GO:0090179,GO:0090244,GO:0090246,GO:0090263,GO:1902043,GO:1904956,GO:2000041,GO:2000052,GO:2000054,GO:2000080,GO:2000270,GO:2000271 osteoblast differentiation|ureteric bud development|positive regulation of cell-matrix adhesion|hematopoietic progenitor cell differentiation|cysteine-type endopeptidase activity|G-protein coupled receptor activity|frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|intracellular|cytosol|plasma membrane|drug binding|heparin binding|positive regulation of cell proliferation|negative regulation of cell proliferation|male gonad development|female gonad development|cellular response to starvation|dorsal/ventral axis specification|cell surface|regulation of cell cycle process|negative regulation of gene expression|negative regulation of epithelial to mesenchymal transition|regulation of neuron projection development|neural crest cell fate commitment|response to organic cyclic compound|integral component of membrane|Wnt-protein binding|menstrual cycle phase|positive regulation of Wnt signaling pathway|negative regulation of Wnt signaling pathway|negative regulation of ossification|positive regulation of cell growth|negative regulation of cell growth|negative regulation of cell migration|negative regulation of BMP signaling pathway|extracellular matrix|negative regulation of osteoblast proliferation|somatic stem cell population maintenance|response to drug|identical protein binding|Wnt-activated receptor activity|positive regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of JUN kinase activity|positive regulation of GTPase activity|cellular response to fibroblast growth factor stimulus|stromal-epithelial cell signaling involved in prostate gland development|negative regulation of B cell differentiation|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|negative regulation of osteoclast differentiation|regulation of angiogenesis|positive regulation of smoothened signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of insulin secretion|negative regulation of bone remodeling|negative regulation of fibroblast proliferation|digestive tract morphogenesis|positive regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of peptidyl-tyrosine phosphorylation|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|canonical Wnt signaling pathway|hematopoietic stem cell differentiation|bone trabecula formation|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|regulation of branching involved in prostate gland morphogenesis|negative regulation of androgen receptor signaling pathway|extracellular exosome|cellular response to vitamin D|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to growth factor stimulus|cellular response to prostaglandin E stimulus|cellular response to estrogen stimulus|cellular response to estradiol stimulus|cellular response to hypoxia|cellular response to X-ray|cellular response to heparin|dopaminergic neuron differentiation|cellular response to transforming growth factor beta stimulus|cellular response to BMP stimulus|negative regulation of canonical Wnt signaling pathway|planar cell polarity pathway involved in neural tube closure|Wnt signaling pathway involved in somitogenesis|convergent extension involved in somitogenesis|positive regulation of canonical Wnt signaling pathway|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of midbrain dopaminergic neuron differentiation|negative regulation of planar cell polarity pathway involved in axis elongation|positive regulation of non-canonical Wnt signaling pathway|negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification|negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of fibroblast apoptotic process|positive regulation of fibroblast apoptotic process hsa04310 Wnt signaling pathway SFRP4 128.485371693793 136.304442326483 120.666301061104 0.885270494501401 -0.175809756696718 0.530884968496411 1 2.12093 1.90306 1.73881 1.86575 GeneID:6424,Genbank:NM_003014.3,HGNC:HGNC:10778,MIM:606570 secreted frizzled related protein 4 hsa04310 Wnt signaling pathway SFSWAP 1005.16475370723 1027.06549128277 983.264016131699 0.957352792472501 -0.0628774270633979 0.67310122292601 1 5.05393 5.23198 4.67639 5.24719 GeneID:6433,Genbank:NM_001261411.1,HGNC:HGNC:10790,MIM:601945 splicing factor SWAP GO:0000380,GO:0000395,GO:0003723,GO:0005634,GO:0006351,GO:0006355,GO:0048025 alternative mRNA splicing, via spliceosome|mRNA 5'-splice site recognition|RNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of mRNA splicing, via spliceosome SFT2D1 1066.15908267 1125.2414338068 1007.07673153319 0.894987245649278 -0.160060972029628 0.283487291047033 1 58.0093 63.8383 57.9195 50.705 GeneID:113402,Genbank:NM_145169.2,HGNC:HGNC:21102 SFT2 domain containing 1 GO:0015031,GO:0016020,GO:0016021,GO:0016192 protein transport|membrane|integral component of membrane|vesicle-mediated transport SFT2D2 132.256704577592 132.681837414042 131.831571741142 0.993591695069415 -0.0092749800369428 0.999324174518374 1 7.88032 7.36158 8.23014 6.86095 GeneID:375035,Genbank:NM_199344.2,HGNC:HGNC:25140 SFT2 domain containing 2 GO:0015031,GO:0016020,GO:0016021,GO:0016192,GO:0070062 protein transport|membrane|integral component of membrane|vesicle-mediated transport|extracellular exosome SFT2D3 434.359092953341 425.297405652998 443.420780253683 1.04261341442433 0.0602043271019659 0.750679287551334 1 9.4163 10.0331 10.0673 10.5611 GeneID:84826,Genbank:NM_032740.3,HGNC:HGNC:28767 SFT2 domain containing 3 GO:0015031,GO:0016020,GO:0016021,GO:0016192 protein transport|membrane|integral component of membrane|vesicle-mediated transport SFTA3 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0220344 0 0 GeneID:253970,Genbank:NM_001352986.1,HGNC:HGNC:18387,MIM:617860 surfactant associated 3 GO:0005576,GO:0005789,GO:0042599,GO:0044267,GO:0045334 extracellular region|endoplasmic reticulum membrane|lamellar body|cellular protein metabolic process|clathrin-coated endocytic vesicle SFTPA1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0142422 GeneID:653509,Genbank:NM_005411.4,HGNC:HGNC:10798,MIM:178630 surfactant protein A1 hsa04145,hsa05133 Phagosome|Pertussis SFTPA2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0134767 0 0 0 GeneID:729238,Genbank:NM_001098668.3,HGNC:HGNC:10799,MIM:178642 surfactant protein A2 hsa04145,hsa05133 Phagosome|Pertussis SFTPC 2.83153189973833 4.20872886376855 1.45433493570811 0.34555206162791 -1.53302500831413 0.487353903625154 1 0.200214 0.0433053 0 0.0429439 GeneID:6440,Genbank:NM_003018.3,HGNC:HGNC:10802,MIM:178620 surfactant protein C SFTPD 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0 0 0 0.0261606 GeneID:6441,Genbank:XM_011540087.1,HGNC:HGNC:10803,MIM:178635 surfactant protein D hsa04145 Phagosome SFXN1 3093.62324711127 3253.75537426367 2933.49111995888 0.901570887338983 -0.14948716474745 0.268381370159907 1 28.7891 30.4143 28.4825 25.9341 GeneID:94081,Genbank:NM_001322977.1,HGNC:HGNC:16085,MIM:615569 sideroflexin 1 GO:0005739,GO:0005743,GO:0006826,GO:0015075,GO:0016021,GO:0030218,GO:0055072 mitochondrion|mitochondrial inner membrane|iron ion transport|ion transmembrane transporter activity|integral component of membrane|erythrocyte differentiation|iron ion homeostasis SFXN2 232.455637186521 243.897602692185 221.013671680857 0.906174022381806 -0.142139961703387 0.50231968454613 1 2.25201 2.53722 2.36566 1.84881 GeneID:118980,Genbank:NM_001350989.1,HGNC:HGNC:16086,MIM:615570 sideroflexin 2 GO:0005743,GO:0015075,GO:0016021,GO:0055072 mitochondrial inner membrane|ion transmembrane transporter activity|integral component of membrane|iron ion homeostasis SFXN3 1329.83852658869 1305.62287634412 1354.05417683326 1.03709440250063 0.0525472228114324 0.7335267269986 1 16.3101 16.9176 18.0228 17.0531 GeneID:81855,Genbank:NM_030971.3,HGNC:HGNC:16087,MIM:615571 sideroflexin 3 GO:0005739,GO:0015075,GO:0016021,GO:0031966,GO:0055072 mitochondrion|ion transmembrane transporter activity|integral component of membrane|mitochondrial membrane|iron ion homeostasis SFXN4 705.346814904667 737.554047589826 673.139582219507 0.9126647523923 -0.131843080111866 0.406180764755574 1 9.60785 9.98322 9.84276 8.99024 GeneID:119559,Genbank:NM_213649.1,HGNC:HGNC:16088,MIM:615564 sideroflexin 4 GO:0005743,GO:0015075,GO:0016021,GO:0043231,GO:0055072 mitochondrial inner membrane|ion transmembrane transporter activity|integral component of membrane|intracellular membrane-bounded organelle|iron ion homeostasis SFXN5 906.977596029226 828.185796984905 985.769395073547 1.19027565874994 0.251295729379265 0.103349389398058 1 5.96607 5.44032 7.24192 6.7668 GeneID:94097,Genbank:NM_001330401.1,HGNC:HGNC:16073,MIM:615572 sideroflexin 5 GO:0005743,GO:0015137,GO:0016021,GO:0055072 mitochondrial inner membrane|citrate transmembrane transporter activity|integral component of membrane|iron ion homeostasis SGCA 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:6442,Genbank:XM_011525121.2,HGNC:HGNC:10805,MIM:600119 sarcoglycan alpha hsa05410,hsa05412,hsa05414,hsa05416 Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Viral myocarditis SGCB 2143.21675812294 2245.97413844491 2040.45937780098 0.908496381536156 -0.138447326548213 0.325863837183339 1 21.5046 21.6547 22.0334 17.372 GeneID:6443,Genbank:NM_000232.4,HGNC:HGNC:10806,MIM:600900 sarcoglycan beta hsa05410,hsa05412,hsa05414,hsa05416 Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Viral myocarditis SGCD 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.00370533 0 0.00712676 0 GeneID:6444,Genbank:XM_017009724.1,HGNC:HGNC:10807,MIM:601411 sarcoglycan delta hsa05410,hsa05412,hsa05414,hsa05416 Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Viral myocarditis SGCE 2334.4836712522 2272.00575767844 2396.96158482596 1.05499802398177 0.0772402967577001 0.578319812829884 1 13.9915 14.2094 15.3887 14.6585 GeneID:8910,Genbank:NM_001301139.1,HGNC:HGNC:10808,MIM:604149 sarcoglycan epsilon GO:0003012,GO:0005794,GO:0005856,GO:0005886,GO:0005887,GO:0007160,GO:0007517,GO:0016010,GO:0016012,GO:0032590,GO:0042383,GO:0061024 muscle system process|Golgi apparatus|cytoskeleton|plasma membrane|integral component of plasma membrane|cell-matrix adhesion|muscle organ development|dystrophin-associated glycoprotein complex|sarcoglycan complex|dendrite membrane|sarcolemma|membrane organization SGCG 9.13220000105116 4.20872886376855 14.0556711383338 3.3396475737209 1.73969586603115 0.0771274581355183 0.94157495521624 0.110276 0.0408469 0.334974 0.136941 GeneID:6445,Genbank:XM_006719861.3,HGNC:HGNC:10809,MIM:608896 sarcoglycan gamma hsa05410,hsa05412,hsa05414,hsa05416 Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM)|Viral myocarditis SGCZ 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.00642486 0 GeneID:137868,Genbank:NM_001322881.1,HGNC:HGNC:14075,MIM:608113 sarcoglycan zeta GO:0005737,GO:0005856,GO:0007517,GO:0016012,GO:0016021,GO:0042383,GO:0046716,GO:0048738,GO:0055001,GO:0060047,GO:0061024 cytoplasm|cytoskeleton|muscle organ development|sarcoglycan complex|integral component of membrane|sarcolemma|muscle cell cellular homeostasis|cardiac muscle tissue development|muscle cell development|heart contraction|membrane organization SGF29 248.176610415728 254.054831964342 242.298388867114 0.953724780566748 -0.0683550917552237 0.773757188208876 1 3.47389 4.56074 4.26067 3.72355 GeneID:112869,Genbank:XM_017022894.1,HGNC:HGNC:25156,MIM:613374 SAGA complex associated factor 29 GO:0005671,GO:0006351,GO:0006355,GO:0016573,GO:0019899,GO:0035064,GO:0043966,GO:0047485,GO:0070461,GO:0071169 Ada2/Gcn5/Ada3 transcription activator complex|transcription, DNA-templated|regulation of transcription, DNA-templated|histone acetylation|enzyme binding|methylated histone binding|histone H3 acetylation|protein N-terminus binding|SAGA-type complex|establishment of protein localization to chromatin SGK1 1565.07396401539 1405.68165223598 1724.46627579481 1.22678294409815 0.294880014140081 0.0467572104861509 0.79332376136203 13.9909 14.4323 20.1027 15.7654 GeneID:6446,Genbank:NM_001143676.1,HGNC:HGNC:10810,MIM:602958 serum/glucocorticoid regulated kinase 1 GO:0001558,GO:0004674,GO:0004712,GO:0005246,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005789,GO:0005829,GO:0005886,GO:0006468,GO:0006814,GO:0006915,GO:0006950,GO:0006974,GO:0007616,GO:0008217,GO:0015459,GO:0016607,GO:0017080,GO:0017081,GO:0018105,GO:0030334,GO:0032411,GO:0034220,GO:0035556,GO:0042127,GO:0042981,GO:0048812,GO:0050790,GO:0051090,GO:0060453,GO:0070294 regulation of cell growth|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|calcium channel regulator activity|ATP binding|nucleus|cytoplasm|mitochondrion|endoplasmic reticulum membrane|cytosol|plasma membrane|protein phosphorylation|sodium ion transport|apoptotic process|response to stress|cellular response to DNA damage stimulus|long-term memory|regulation of blood pressure|potassium channel regulator activity|nuclear speck|sodium channel regulator activity|chloride channel regulator activity|peptidyl-serine phosphorylation|regulation of cell migration|positive regulation of transporter activity|ion transmembrane transport|intracellular signal transduction|regulation of cell proliferation|regulation of apoptotic process|neuron projection morphogenesis|regulation of catalytic activity|regulation of DNA binding transcription factor activity|regulation of gastric acid secretion|renal sodium ion absorption hsa04068,hsa04150,hsa04151,hsa04960 FoxO signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Aldosterone-regulated sodium reabsorption SGK2 1.58734335687265 2.69048838321152 0.484198330533773 0.17996670550787 -2.47419806745255 0.581508620156048 1 0.0349657 0 0 0 GeneID:10110,Genbank:NM_170693.2,HGNC:HGNC:13900,MIM:607589 SGK2, serine/threonine kinase 2 GO:0001558,GO:0004674,GO:0005246,GO:0005524,GO:0005622,GO:0005654,GO:0005829,GO:0006468,GO:0006979,GO:0015459,GO:0017080,GO:0017081,GO:0018105,GO:0032411,GO:0034220,GO:0035556,GO:0042127,GO:0042981 regulation of cell growth|protein serine/threonine kinase activity|calcium channel regulator activity|ATP binding|intracellular|nucleoplasm|cytosol|protein phosphorylation|response to oxidative stress|potassium channel regulator activity|sodium channel regulator activity|chloride channel regulator activity|peptidyl-serine phosphorylation|positive regulation of transporter activity|ion transmembrane transport|intracellular signal transduction|regulation of cell proliferation|regulation of apoptotic process hsa04068,hsa04151 FoxO signaling pathway|PI3K-Akt signaling pathway SGK3 1.99286759837712 1.07619535328461 2.90953984346962 2.70354246985879 1.43485101984636 0.610173131544216 1 0.807467 0.384364 0.726267 0.346019 GeneID:23678,Genbank:NM_001033578.2,HGNC:HGNC:10812,MIM:607591 serum/glucocorticoid regulated kinase family member 3 GO:0001558,GO:0004672,GO:0004674,GO:0005246,GO:0005524,GO:0005769,GO:0005829,GO:0006468,GO:0006950,GO:0015459,GO:0017080,GO:0017081,GO:0018105,GO:0030334,GO:0031410,GO:0032411,GO:0034220,GO:0035091,GO:0035556,GO:0042127,GO:0042981,GO:0051090,GO:0055037 regulation of cell growth|protein kinase activity|protein serine/threonine kinase activity|calcium channel regulator activity|ATP binding|early endosome|cytosol|protein phosphorylation|response to stress|potassium channel regulator activity|sodium channel regulator activity|chloride channel regulator activity|peptidyl-serine phosphorylation|regulation of cell migration|cytoplasmic vesicle|positive regulation of transporter activity|ion transmembrane transport|phosphatidylinositol binding|intracellular signal transduction|regulation of cell proliferation|regulation of apoptotic process|regulation of DNA binding transcription factor activity|recycling endosome hsa04068,hsa04151 FoxO signaling pathway|PI3K-Akt signaling pathway SGK494 36.6653717625912 38.4362747607751 34.8944687644073 0.907852516446722 -0.139470148773026 0.789504766913014 1 0.285635 0.362176 0.235058 0.242489 GeneID:124923,Genbank:NM_001174103.1 uncharacterized serine/threonine-protein kinase SgK494 GO:0004674,GO:0005524 protein serine/threonine kinase activity|ATP binding SGMS1 481.504862828238 513.738546721931 449.271178934545 0.874513274896852 -0.193447810817625 0.282026082366737 1 1.86792 1.67359 1.65942 1.47754 GeneID:259230,Genbank:NM_147156.3,HGNC:HGNC:29799,MIM:611573 sphingomyelin synthase 1 GO:0000138,GO:0000139,GO:0002950,GO:0005634,GO:0005783,GO:0005886,GO:0005887,GO:0006686,GO:0006915,GO:0016020,GO:0016301,GO:0030148,GO:0030173,GO:0030176,GO:0033188,GO:0046513,GO:0047493,GO:2001242 Golgi trans cisterna|Golgi membrane|ceramide phosphoethanolamine synthase activity|nucleus|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|sphingomyelin biosynthetic process|apoptotic process|membrane|kinase activity|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|sphingomyelin synthase activity|ceramide biosynthetic process|ceramide cholinephosphotransferase activity|regulation of intrinsic apoptotic signaling pathway hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway SGMS2 114.32845157111 114.751109295467 113.905793846752 0.992633487781468 -0.0106669682381243 1 1 0.682216 0.507982 0.719976 0.490642 GeneID:166929,Genbank:XM_011531701.2,HGNC:HGNC:28395,MIM:611574 sphingomyelin synthase 2 GO:0002950,GO:0005794,GO:0005886,GO:0005887,GO:0006686,GO:0016301,GO:0030148,GO:0030173,GO:0030176,GO:0033188,GO:0046513,GO:0047493,GO:1905373 ceramide phosphoethanolamine synthase activity|Golgi apparatus|plasma membrane|integral component of plasma membrane|sphingomyelin biosynthetic process|kinase activity|sphingolipid biosynthetic process|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|sphingomyelin synthase activity|ceramide biosynthetic process|ceramide cholinephosphotransferase activity|ceramide phosphoethanolamine biosynthetic process hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway SGO1 478.794204742624 518.985253319407 438.603156165841 0.845116799293533 -0.242777352170811 0.173204633876636 1 2.47722 2.5205 2.28298 1.99401 GeneID:151648,Genbank:NM_138484.4,HGNC:HGNC:25088,MIM:609168 shugoshin 1 GO:0000775,GO:0000776,GO:0000777,GO:0000779,GO:0000922,GO:0005654,GO:0005813,GO:0005829,GO:0007059,GO:0007062,GO:0008608,GO:0010457,GO:0019900,GO:0045132,GO:0051301,GO:0071962 chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed chromosome, centromeric region|spindle pole|nucleoplasm|centrosome|cytosol|chromosome segregation|sister chromatid cohesion|attachment of spindle microtubules to kinetochore|centriole-centriole cohesion|kinase binding|meiotic chromosome segregation|cell division|mitotic sister chromatid cohesion, centromeric hsa04114 Oocyte meiosis SGO2 94.7057193492995 91.4972393402624 97.9141993583366 1.0701328265677 0.0977898773156115 0.794561699498588 1 0.495587 0.372045 0.606369 0.345194 GeneID:151246,Genbank:XM_017003453.1,HGNC:HGNC:30812,MIM:612425 shugoshin 2 GO:0000775,GO:0000777,GO:0005654,GO:0005829,GO:0007062,GO:0016604,GO:0030892,GO:0051301,GO:0051754 chromosome, centromeric region|condensed chromosome kinetochore|nucleoplasm|cytosol|sister chromatid cohesion|nuclear body|mitotic cohesin complex|cell division|meiotic sister chromatid cohesion, centromeric SGPL1 2037.7600969406 1900.42410114201 2175.09609273919 1.1445319449654 0.194757730434004 0.169170733313384 1 11.8223 12.4471 14.7373 13.1398 GeneID:8879,Genbank:XM_011540316.2,HGNC:HGNC:10817,MIM:603729 sphingosine-1-phosphate lyase 1 GO:0001553,GO:0001570,GO:0001822,GO:0005783,GO:0005789,GO:0006631,GO:0006672,GO:0007283,GO:0008117,GO:0008209,GO:0008210,GO:0009791,GO:0010761,GO:0016831,GO:0030097,GO:0030148,GO:0030149,GO:0030170,GO:0030176,GO:0033327,GO:0040014,GO:0048008,GO:0048705,GO:0060021,GO:0060325,GO:0097190 luteinization|vasculogenesis|kidney development|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|ceramide metabolic process|spermatogenesis|sphinganine-1-phosphate aldolase activity|androgen metabolic process|estrogen metabolic process|post-embryonic development|fibroblast migration|carboxy-lyase activity|hemopoiesis|sphingolipid biosynthetic process|sphingolipid catabolic process|pyridoxal phosphate binding|integral component of endoplasmic reticulum membrane|Leydig cell differentiation|regulation of multicellular organism growth|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|palate development|face morphogenesis|apoptotic signaling pathway hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway SGPP1 443.268526495939 499.766607438592 386.770445553285 0.77390213711069 -0.369776951297384 0.0643639055025321 0.90091963811897 8.17628 7.02908 6.7079 5.20685 GeneID:81537,Genbank:XM_017021678.2,HGNC:HGNC:17720,MIM:612826 sphingosine-1-phosphate phosphatase 1 GO:0005634,GO:0005654,GO:0005789,GO:0005886,GO:0006668,GO:0006670,GO:0016021,GO:0030148,GO:0042392,GO:0070780,GO:0097191,GO:0097193 nucleus|nucleoplasm|endoplasmic reticulum membrane|plasma membrane|sphinganine-1-phosphate metabolic process|sphingosine metabolic process|integral component of membrane|sphingolipid biosynthetic process|sphingosine-1-phosphate phosphatase activity|dihydrosphingosine-1-phosphate phosphatase activity|extrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway SGPP2 3.07025954326672 3.71865746181119 2.42186162472226 0.65127311391103 -0.618665424835064 0.839262793473304 1 0.0358989 0.00823457 0.00851705 0.031759 GeneID:130367,Genbank:NM_001320834.1,HGNC:HGNC:19953,MIM:612827 sphingosine-1-phosphate phosphatase 2 GO:0005783,GO:0005789,GO:0006670,GO:0016021,GO:0030148,GO:0042392,GO:0070780 endoplasmic reticulum|endoplasmic reticulum membrane|sphingosine metabolic process|integral component of membrane|sphingolipid biosynthetic process|sphingosine-1-phosphate phosphatase activity|dihydrosphingosine-1-phosphate phosphatase activity hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway SGSH 508.627691275109 522.945059155497 494.31032339472 0.945243319045752 -0.0812423475683984 0.628929074533759 1 4.70556 4.73776 4.55954 4.44718 GeneID:6448,Genbank:XM_005257583.4,HGNC:HGNC:10818,MIM:605270 N-sulfoglucosamine sulfohydrolase GO:0005764,GO:0006027,GO:0008484,GO:0016250,GO:0030200,GO:0043202,GO:0046872,GO:0070062 lysosome|glycosaminoglycan catabolic process|sulfuric ester hydrolase activity|N-sulfoglucosamine sulfohydrolase activity|heparan sulfate proteoglycan catabolic process|lysosomal lumen|metal ion binding|extracellular exosome hsa00531,hsa04142 Glycosaminoglycan degradation|Lysosome SGSM1 2.7776325536298 3.13253351048394 2.42273159677566 0.773409634299929 -0.370695358821752 0.960660496689595 1 0.0271148 0.0120729 0.0126924 0.0177821 GeneID:129049,Genbank:NM_001039948.3,HGNC:HGNC:29410,MIM:611417 small G protein signaling modulator 1 GO:0005096,GO:0005737,GO:0005794,GO:0005829,GO:0006886,GO:0012505,GO:0017137,GO:0030659,GO:0031338,GO:0090630 GTPase activator activity|cytoplasm|Golgi apparatus|cytosol|intracellular protein transport|endomembrane system|Rab GTPase binding|cytoplasmic vesicle membrane|regulation of vesicle fusion|activation of GTPase activity SGSM2 1187.54641674523 1142.797760383 1232.29507310746 1.07831421781441 0.108777636743493 0.583876367605176 1 4.72698 5.17004 4.78243 5.99816 GeneID:9905,Genbank:XM_011524101.3,HGNC:HGNC:29026,MIM:611418 small G protein signaling modulator 2 GO:0005096,GO:0005737,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0034499,GO:0042470,GO:0043547,GO:0090630 GTPase activator activity|cytoplasm|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|late endosome to Golgi transport|melanosome|positive regulation of GTPase activity|activation of GTPase activity SGSM3 831.864175132446 777.844746753953 885.88360351094 1.13889514226052 0.187634924653941 0.239843686229049 1 6.33465 6.39451 7.65898 7.37925 GeneID:27352,Genbank:NM_001350039.1,HGNC:HGNC:25228,MIM:610440 small G protein signaling modulator 3 GO:0005096,GO:0005829,GO:0005921,GO:0006886,GO:0007050,GO:0012505,GO:0017137,GO:0031338,GO:0032483,GO:0032486,GO:0043547,GO:0045732,GO:0048227,GO:0090630 GTPase activator activity|cytosol|gap junction|intracellular protein transport|cell cycle arrest|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|regulation of Rab protein signal transduction|Rap protein signal transduction|positive regulation of GTPase activity|positive regulation of protein catabolic process|plasma membrane to endosome transport|activation of GTPase activity SGTA 3988.31552334551 3918.43692978932 4058.1941169017 1.03566656542304 0.0505595997051035 0.729623040675045 1 58.4346 62.3011 64.2147 64.6358 GeneID:6449,Genbank:NM_003021.3,HGNC:HGNC:10819,MIM:603419 small glutamine rich tetratricopeptide repeat containing alpha GO:0005634,GO:0005737,GO:0005829,GO:0016020,GO:0016032,GO:0030433,GO:0043621,GO:1903070,GO:1903071,GO:1904288,GO:2000059 nucleus|cytoplasm|cytosol|membrane|viral process|ubiquitin-dependent ERAD pathway|protein self-association|negative regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|BAT3 complex binding|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process SGTB 197.376972384633 191.191422344853 203.562522424413 1.06470530909721 0.0904541741737845 0.692914781341054 1 1.24526 1.27276 1.5734 1.18498 GeneID:54557,Genbank:XM_005248548.3,HGNC:HGNC:23567 small glutamine rich tetratricopeptide repeat containing beta SH2B1 762.084522521268 656.251238140444 867.917806902093 1.32253892482006 0.403310184205809 0.0117730501466882 0.442622467486757 3.97428 3.90392 5.01665 5.62582 GeneID:25970,Genbank:NM_001308293.1,HGNC:HGNC:30417,MIM:608937 SH2B adaptor protein 1 GO:0004871,GO:0005634,GO:0005829,GO:0007596,GO:0016020,GO:0030032,GO:0035556,GO:0035591,GO:0045840,GO:2000278 signal transducer activity|nucleus|cytosol|blood coagulation|membrane|lamellipodium assembly|intracellular signal transduction|signaling adaptor activity|positive regulation of mitotic nuclear division|regulation of DNA biosynthetic process hsa04722 Neurotrophin signaling pathway SH2B2 145.273184276396 143.713348285637 146.833020267155 1.02170760071165 0.0309823749834924 0.93155906727671 1 2.04466 2.31955 2.17275 2.49986 GeneID:10603,Genbank:XM_005276975.5,HGNC:HGNC:17381,MIM:605300 SH2B adaptor protein 2 GO:0004871,GO:0005070,GO:0005737,GO:0005829,GO:0005886,GO:0007165,GO:0007596,GO:0008269,GO:0008286,GO:0035556 signal transducer activity|SH3/SH2 adaptor activity|cytoplasm|cytosol|plasma membrane|signal transduction|blood coagulation|JAK pathway signal transduction adaptor activity|insulin receptor signaling pathway|intracellular signal transduction hsa04722,hsa04910 Neurotrophin signaling pathway|Insulin signaling pathway SH2B3 2375.02365564805 2595.65952037498 2154.38779092112 0.829996297283972 -0.268823194454267 0.0508300625621641 0.826491656848345 15.2331 15.8091 14.8381 11.4002 GeneID:10019,Genbank:XM_011537720.3,HGNC:HGNC:29605,MIM:605093 SH2B adaptor protein 3 GO:0004871,GO:0005829,GO:0007596,GO:0030154,GO:0035162,GO:0035556,GO:0035591 signal transducer activity|cytosol|blood coagulation|cell differentiation|embryonic hemopoiesis|intracellular signal transduction|signaling adaptor activity hsa04722 Neurotrophin signaling pathway SH2D1A 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0196029 0 0 GeneID:4068,Genbank:NM_002351.4,HGNC:HGNC:10820,MIM:300490 SH2 domain containing 1A hsa04650,hsa05162 Natural killer cell mediated cytotoxicity|Measles SH2D1B 1.27070322989325 2.05633815719933 0.48506830258717 0.235889365223771 -2.08381771694066 0.63179572723844 1 0.0382443 0.0361882 0.01832 0 GeneID:117157,Genbank:NM_053282.4,HGNC:HGNC:30416,MIM:608510 SH2 domain containing 1B GO:0002250,GO:0002366,GO:0002717,GO:0005622,GO:0005829,GO:0030674,GO:0045087,GO:0045089,GO:0050776 adaptive immune response|leukocyte activation involved in immune response|positive regulation of natural killer cell mediated immunity|intracellular|cytosol|protein binding, bridging|innate immune response|positive regulation of innate immune response|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity SH2D2A 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0191637 0 0 GeneID:9047,Genbank:XM_017002767.1,HGNC:HGNC:10821,MIM:604514 SH2 domain containing 2A GO:0001525,GO:0005070,GO:0005737,GO:0005829,GO:0007165,GO:0008283,GO:0017124,GO:0030154,GO:0048010 angiogenesis|SH3/SH2 adaptor activity|cytoplasm|cytosol|signal transduction|cell proliferation|SH3 domain binding|cell differentiation|vascular endothelial growth factor receptor signaling pathway hsa04370 VEGF signaling pathway SH2D3A 2.02688693445997 3.084507235799 0.969266633120943 0.314237107915186 -1.67007453792131 0.551886710190974 1 0.0142857 0.0124234 0 0.0123477 GeneID:10045,Genbank:XM_011527609.2,HGNC:HGNC:16885,MIM:604721 SH2 domain containing 3A GO:0005070,GO:0005085,GO:0005622,GO:0007254,GO:0007264 SH3/SH2 adaptor activity|guanyl-nucleotide exchange factor activity|intracellular|JNK cascade|small GTPase mediated signal transduction SH2D3C 0.729234031512454 0.490071401957362 0.968396661067546 1.97603177251261 0.982606144127986 1 1 0 0 0 0 GeneID:10044,Genbank:NM_170600.2,HGNC:HGNC:16884,MIM:604722 SH2 domain containing 3C GO:0005070,GO:0005085,GO:0005737,GO:0007254,GO:0007264,GO:0016020 SH3/SH2 adaptor activity|guanyl-nucleotide exchange factor activity|cytoplasm|JNK cascade|small GTPase mediated signal transduction|membrane SH2D4A 558.999859727451 583.491364933292 534.50835452161 0.916051867507445 -0.126498807834468 0.457219063155278 1 4.52488 4.63795 4.17626 4.4726 GeneID:63898,Genbank:XM_011544610.1,HGNC:HGNC:26102,MIM:614968 SH2 domain containing 4A GO:0005829,GO:0010923,GO:0019902 cytosol|negative regulation of phosphatase activity|phosphatase binding SH2D5 181.691172156506 187.444355918573 175.937988394439 0.938614489256043 -0.091395363674718 0.686907200584339 1 1.4924 1.65162 1.65367 1.31774 GeneID:400745,Genbank:XM_011541461.2,HGNC:HGNC:28819 SH2 domain containing 5 GO:0014069,GO:0030054,GO:0045211 postsynaptic density|cell junction|postsynaptic membrane SH2D6 7.31440816147852 8.81147658012458 5.81733974283245 0.660200329642164 -0.599024235980055 0.631470614813559 1 0.0122714 0.0110673 0.0288302 0 GeneID:284948,Genbank:NM_201594.2,HGNC:HGNC:30439 SH2 domain containing 6 GO:0005068,GO:0005070,GO:0005737,GO:0006955,GO:0035556 transmembrane receptor protein tyrosine kinase adaptor activity|SH3/SH2 adaptor activity|cytoplasm|immune response|intracellular signal transduction SH3BGR 7.3275451280272 6.89921724698007 7.75587300907434 1.12416709482068 0.16885649192212 0.912824528100546 1 1.04513 0.673494 1.16584 1.00202 GeneID:6450,Genbank:NM_001317742.1,HGNC:HGNC:10822,MIM:602230 SH3 domain binding glutamate rich protein GO:0005070,GO:0005829,GO:0006461,GO:0017124 SH3/SH2 adaptor activity|cytosol|protein complex assembly|SH3 domain binding SH3BGRL 659.816576397731 667.329758285868 652.303394509594 0.977482850735036 -0.0328567033385231 0.862023598078099 1 9.86252 9.47214 9.55904 9.27691 GeneID:6451,Genbank:NM_003022.2,HGNC:HGNC:10823,MIM:300190 SH3 domain binding glutamate rich protein like GO:0005070,GO:0005615,GO:0005634,GO:0005737,GO:0017124,GO:0070062 SH3/SH2 adaptor activity|extracellular space|nucleus|cytoplasm|SH3 domain binding|extracellular exosome SH3BGRL2 293.830055924588 308.479132544369 279.180979304807 0.905023873096674 -0.143972246178899 0.600224800601272 1 2.48933 2.10423 2.47089 1.7002 GeneID:83699,Genbank:NM_031469.3,HGNC:HGNC:15567,MIM:615678 SH3 domain binding glutamate rich protein like 2 GO:0005654,GO:0005737,GO:0017124,GO:0031965,GO:0070062 nucleoplasm|cytoplasm|SH3 domain binding|nuclear membrane|extracellular exosome SH3BGRL3 2658.95781997195 2545.85656782067 2772.05907212323 1.08885123661786 0.12280686052482 0.383547614661988 1 107.997 111.738 124.417 121.81 GeneID:83442,Genbank:NM_031286.3,HGNC:HGNC:15568,MIM:615679 SH3 domain binding glutamate rich protein like 3 GO:0005737,GO:0009055,GO:0015035,GO:0016604,GO:0045454,GO:0070062 cytoplasm|electron transfer activity|protein disulfide oxidoreductase activity|nuclear body|cell redox homeostasis|extracellular exosome SH3BP1 140.60243087831 161.499997580156 119.704864176463 0.741206600433853 -0.432052366286905 0.0885612893118976 0.974174182430873 1.83037 2.20774 1.61039 1.37947 GeneID:23616,Genbank:NM_018957.4,HGNC:HGNC:10824,MIM:617368 SH3 domain binding protein 1 GO:0001891,GO:0005096,GO:0005634,GO:0005829,GO:0005912,GO:0005923,GO:0006911,GO:0007015,GO:0016477,GO:0017124,GO:0030027,GO:0030215,GO:0030834,GO:0031252,GO:0032956,GO:0034329,GO:0043535,GO:0043547,GO:0045198,GO:0046847,GO:0051058,GO:0071526 phagocytic cup|GTPase activator activity|nucleus|cytosol|adherens junction|bicellular tight junction|phagocytosis, engulfment|actin filament organization|cell migration|SH3 domain binding|lamellipodium|semaphorin receptor binding|regulation of actin filament depolymerization|cell leading edge|regulation of actin cytoskeleton organization|cell junction assembly|regulation of blood vessel endothelial cell migration|positive regulation of GTPase activity|establishment of epithelial cell apical/basal polarity|filopodium assembly|negative regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway SH3BP2 1016.33559161725 1044.58258323854 988.088599995969 0.945917169069179 -0.0802142379665406 0.595469833477079 1 4.70621 4.74767 4.2353 4.78969 GeneID:6452,Genbank:NM_001122681.1,HGNC:HGNC:10825,MIM:602104 SH3 domain binding protein 2 GO:0001784,GO:0005070,GO:0007165,GO:0017124 phosphotyrosine residue binding|SH3/SH2 adaptor activity|signal transduction|SH3 domain binding hsa04650 Natural killer cell mediated cytotoxicity SH3BP4 5498.86519174759 5629.92480949496 5367.80557400021 0.953441787525708 -0.0687832375362386 0.59528968185555 1 25.9511 27.0819 26.6211 24.8302 GeneID:23677,Genbank:NM_014521.2,HGNC:HGNC:10826,MIM:605611 SH3 domain binding protein 4 GO:0005092,GO:0005634,GO:0005737,GO:0005905,GO:0006897,GO:0008285,GO:0010508,GO:0017016,GO:0030136,GO:0030308,GO:0032007,GO:0034260,GO:0042802,GO:0050790,GO:0061462,GO:0070062,GO:0071230 GDP-dissociation inhibitor activity|nucleus|cytoplasm|clathrin-coated pit|endocytosis|negative regulation of cell proliferation|positive regulation of autophagy|Ras GTPase binding|clathrin-coated vesicle|negative regulation of cell growth|negative regulation of TOR signaling|negative regulation of GTPase activity|identical protein binding|regulation of catalytic activity|protein localization to lysosome|extracellular exosome|cellular response to amino acid stimulus SH3BP5 1347.60904329444 1295.5901085858 1399.62797800307 1.08030153111529 0.111434050100365 0.44646885682307 1 10.0128 10.3134 11.2191 10.6019 GeneID:9467,Genbank:NM_001018009.3,HGNC:HGNC:10827,MIM:605612 SH3 domain binding protein 5 GO:0004860,GO:0005654,GO:0005737,GO:0005739,GO:0007165,GO:0016604,GO:0017124,GO:0035556,GO:0061099 protein kinase inhibitor activity|nucleoplasm|cytoplasm|mitochondrion|signal transduction|nuclear body|SH3 domain binding|intracellular signal transduction|negative regulation of protein tyrosine kinase activity SH3BP5L 1411.47289733536 1376.89393503604 1446.05185963468 1.05022748872579 0.0707018624712069 0.647162754549515 1 8.94191 9.8802 9.83625 10.6234 GeneID:80851,Genbank:NM_001322464.1,HGNC:HGNC:29360 SH3 binding domain protein 5 like GO:0004860,GO:0005737,GO:0017124,GO:0035556,GO:0061099 protein kinase inhibitor activity|cytoplasm|SH3 domain binding|intracellular signal transduction|negative regulation of protein tyrosine kinase activity SH3D19 591.652591894788 574.554409838474 608.750773951103 1.05951806047793 0.0834081800082187 0.611971552674888 1 2.04797 2.04922 2.50946 1.90751 GeneID:152503,Genbank:XM_011531649.2,HGNC:HGNC:30418,MIM:608674 SH3 domain containing 19 GO:0005654,GO:0005829,GO:0005886,GO:0007010,GO:0022604,GO:0051044,GO:0070064 nucleoplasm|cytosol|plasma membrane|cytoskeleton organization|regulation of cell morphogenesis|positive regulation of membrane protein ectodomain proteolysis|proline-rich region binding SH3D21 48.0756682776666 38.0040382886107 58.1472982667226 1.53002946226766 0.613559433740285 0.168877930019196 1 0.186882 0.244974 0.287673 0.340722 GeneID:79729,Genbank:XM_017002340.1,HGNC:HGNC:26236 SH3 domain containing 21 GO:0005634,GO:0005654,GO:0005886,GO:0070062 nucleus|nucleoplasm|plasma membrane|extracellular exosome SH3GL1 3083.35827627046 3082.15903334371 3084.5575191972 1.00077818367824 0.00112224513368843 0.984502081427677 1 41.1693 43.3924 42.6863 43.356 GeneID:6455,Genbank:NM_001199943.1,HGNC:HGNC:10830,MIM:601768 SH3 domain containing GRB2 like 1, endophilin A2 hsa04144 Endocytosis SH3GL2 125.265993299927 121.131846176021 129.400140423833 1.06825863312441 0.0952609761956697 0.735789148103584 1 0.532047 0.528241 0.594675 0.490275 GeneID:6456,Genbank:NM_003026.3,HGNC:HGNC:10831,MIM:604465 SH3 domain containing GRB2 like 2, endophilin A1 hsa04144 Endocytosis SH3GL3 34.2134690407941 29.1729443982702 39.2539936833181 1.34556159801428 0.428208437143759 0.362906936054346 1 0.140474 0.0752233 0.140357 0.149072 GeneID:6457,Genbank:XM_011521889.1,HGNC:HGNC:10832,MIM:603362 SH3 domain containing GRB2 like 3, endophilin A3 GO:0006897,GO:0007165,GO:0007417,GO:0008022,GO:0008289,GO:0031901,GO:0042802,GO:0070062 endocytosis|signal transduction|central nervous system development|protein C-terminus binding|lipid binding|early endosome membrane|identical protein binding|extracellular exosome hsa04144 Endocytosis SH3GLB1 1365.23677583014 1399.57824734757 1330.89530431271 0.950925971330991 -0.072595061846449 0.637901441800257 1 7.42388 7.00882 7.7725 6.10144 GeneID:51100,Genbank:XM_006710672.2,HGNC:HGNC:10833,MIM:609287 SH3 domain containing GRB2 like, endophilin B1 GO:0000139,GO:0000421,GO:0005737,GO:0005741,GO:0005829,GO:0006914,GO:0006915,GO:0008289,GO:0010508,GO:0016241,GO:0030496,GO:0031410,GO:0031647,GO:0032461,GO:0032465,GO:0032801,GO:0034198,GO:0042149,GO:0042802,GO:0042803,GO:0045296,GO:0048102,GO:0051259,GO:0070062,GO:0090148,GO:1903527,GO:1903778,GO:1903955,GO:2000786 Golgi membrane|autophagosome membrane|cytoplasm|mitochondrial outer membrane|cytosol|autophagy|apoptotic process|lipid binding|positive regulation of autophagy|regulation of macroautophagy|midbody|cytoplasmic vesicle|regulation of protein stability|positive regulation of protein oligomerization|regulation of cytokinesis|receptor catabolic process|cellular response to amino acid starvation|cellular response to glucose starvation|identical protein binding|protein homodimerization activity|cadherin binding|autophagic cell death|protein oligomerization|extracellular exosome|membrane fission|positive regulation of membrane tubulation|protein localization to vacuolar membrane|positive regulation of protein targeting to mitochondrion|positive regulation of autophagosome assembly hsa04140,hsa04144 Autophagy - animal|Endocytosis SH3GLB2 1309.14223294917 1339.3897768045 1278.89468909385 0.954833843920348 -0.0666783914853551 0.633208791827284 1 15.56 15.9394 15.8407 15.8026 GeneID:56904,Genbank:NM_001287046.1,HGNC:HGNC:10834,MIM:609288 SH3 domain containing GRB2 like, endophilin B2 GO:0005737,GO:0042802,GO:0045296 cytoplasm|identical protein binding|cadherin binding hsa04144 Endocytosis SH3KBP1 912.174011619523 863.278832827095 961.069190411951 1.11327783546436 0.154813684167392 0.324380219298364 1 3.69127 3.98789 4.8504 4.01336 GeneID:30011,Genbank:NM_001353890.1,HGNC:HGNC:13867,MIM:300374 SH3 domain containing kinase binding protein 1 GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005911,GO:0005925,GO:0006897,GO:0006915,GO:0007010,GO:0007267,GO:0007411,GO:0008360,GO:0016477,GO:0017124,GO:0030139,GO:0030659,GO:0042059,GO:0043005,GO:0045202,GO:0061024 cytoplasm|cytosol|cytoskeleton|plasma membrane|cell-cell junction|focal adhesion|endocytosis|apoptotic process|cytoskeleton organization|cell-cell signaling|axon guidance|regulation of cell shape|cell migration|SH3 domain binding|endocytic vesicle|cytoplasmic vesicle membrane|negative regulation of epidermal growth factor receptor signaling pathway|neuron projection|synapse|membrane organization hsa04144 Endocytosis SH3PXD2A 220.144831730974 219.288171389839 221.001492072109 1.00781310123301 0.0112281160948794 0.952418277614384 1 0.716214 0.620316 0.719702 0.622865 GeneID:9644,Genbank:NM_014631.2,HGNC:HGNC:23664 SH3 and PX domains 2A GO:0002102,GO:0005829,GO:0006801,GO:0016176,GO:0030054,GO:0030198,GO:0035091,GO:0042995,GO:0055114,GO:0071800,GO:0072675 podosome|cytosol|superoxide metabolic process|superoxide-generating NADPH oxidase activator activity|cell junction|extracellular matrix organization|phosphatidylinositol binding|cell projection|oxidation-reduction process|podosome assembly|osteoclast fusion SH3PXD2B 3401.89084364105 3067.74301493139 3736.0386723507 1.21784603670078 0.284331755470601 0.0364183224765931 0.739899327172153 13.9787 14.1275 17.8493 16.6843 GeneID:285590,Genbank:NM_001308175.1,HGNC:HGNC:29242,MIM:613293 SH3 and PX domains 2B GO:0001501,GO:0001654,GO:0002051,GO:0002102,GO:0005737,GO:0006801,GO:0007507,GO:0010314,GO:0010628,GO:0016176,GO:0022617,GO:0030054,GO:0032266,GO:0040018,GO:0042169,GO:0042995,GO:0045600,GO:0048705,GO:0051496,GO:0055114,GO:0060348,GO:0060378,GO:0060612,GO:0070273,GO:0071800,GO:0072657,GO:0080025,GO:1904179,GO:1904888 skeletal system development|eye development|osteoblast fate commitment|podosome|cytoplasm|superoxide metabolic process|heart development|phosphatidylinositol-5-phosphate binding|positive regulation of gene expression|superoxide-generating NADPH oxidase activator activity|extracellular matrix disassembly|cell junction|phosphatidylinositol-3-phosphate binding|positive regulation of multicellular organism growth|SH2 domain binding|cell projection|positive regulation of fat cell differentiation|skeletal system morphogenesis|positive regulation of stress fiber assembly|oxidation-reduction process|bone development|regulation of brood size|adipose tissue development|phosphatidylinositol-4-phosphate binding|podosome assembly|protein localization to membrane|phosphatidylinositol-3,5-bisphosphate binding|positive regulation of adipose tissue development|cranial skeletal system development SH3RF1 677.793541841335 645.527502227175 710.059581455496 1.09996797813521 0.137461525151775 0.431672062329698 1 4.7558 4.93167 6.10154 4.62646 GeneID:57630,Genbank:NM_020870.3,HGNC:HGNC:17650 SH3 domain containing ring finger 1 GO:0005794,GO:0005829,GO:0006915,GO:0016567,GO:0016740,GO:0030027,GO:0043066,GO:0043154,GO:0046328,GO:0046872,GO:0048471,GO:2001237 Golgi apparatus|cytosol|apoptotic process|protein ubiquitination|transferase activity|lamellipodium|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of JNK cascade|metal ion binding|perinuclear region of cytoplasm|negative regulation of extrinsic apoptotic signaling pathway SH3RF2 211.213214713301 205.797511854204 216.628917572397 1.05263137353121 0.0740002999085267 0.760077981804116 1 1.0773 1.17284 1.27387 1.13507 GeneID:153769,Genbank:NM_152550.3,HGNC:HGNC:26299,MIM:613377 SH3 domain containing ring finger 2 GO:0004864,GO:0005654,GO:0008157,GO:0010923,GO:0016567,GO:0016740,GO:0019902,GO:0046872 protein phosphatase inhibitor activity|nucleoplasm|protein phosphatase 1 binding|negative regulation of phosphatase activity|protein ubiquitination|transferase activity|phosphatase binding|metal ion binding SH3RF3 269.685527102908 235.028291182267 304.342763023549 1.29491969452957 0.372862630810418 0.0732945504950852 0.934750619674839 0.797719 0.907666 1.14821 1.08789 GeneID:344558,Genbank:XM_011511109.2,HGNC:HGNC:24699 SH3 domain containing ring finger 3 GO:0046872 metal ion binding SH3TC1 23.4767879764599 28.0585314254086 18.8950445275113 0.673415306062696 -0.570431582320267 0.331931905004666 1 0.142394 0.147732 0.0899512 0.103813 GeneID:54436,Genbank:XM_011513488.1,HGNC:HGNC:26009 SH3 domain and tetratricopeptide repeats 1 SH3TC2 125.99220161857 118.70110647645 133.28329676069 1.12284797266935 0.167162608127379 0.571264157250573 1 0.128532 0.183309 0.194355 0.155737 GeneID:79628,Genbank:NM_024577.3,HGNC:HGNC:29427,MIM:608206 SH3 domain and tetratricopeptide repeats 2 SH3YL1 98.3939319270351 116.336993360925 80.4508704931451 0.691533003982263 -0.532129988059248 0.0753206589802136 0.94157495521624 1.79158 1.73704 1.20614 1.20222 GeneID:26751,Genbank:NM_001282682.1,HGNC:HGNC:29546,MIM:617314 SH3 and SYLF domain containing 1 GO:0006661,GO:0019902,GO:0032587,GO:0035091,GO:1900027 phosphatidylinositol biosynthetic process|phosphatase binding|ruffle membrane|phosphatidylinositol binding|regulation of ruffle assembly SHANK1 1.6959991149483 0 3.3919982298966 Inf Inf 0.190717063916481 1 0 0 0.00979976 0.0138041 GeneID:50944,Genbank:NM_016148.4,HGNC:HGNC:15474,MIM:604999 SH3 and multiple ankyrin repeat domains 1 GO:0005622,GO:0005829,GO:0005886,GO:0006461,GO:0007016,GO:0007616,GO:0008022,GO:0008306,GO:0014069,GO:0016020,GO:0017124,GO:0017146,GO:0030054,GO:0030160,GO:0030425,GO:0030534,GO:0031877,GO:0032232,GO:0032403,GO:0035176,GO:0035255,GO:0035418,GO:0042048,GO:0042802,GO:0043005,GO:0043197,GO:0045211,GO:0046959,GO:0050885,GO:0050894,GO:0060013,GO:0060074,GO:0060076,GO:0060997,GO:0060999,GO:0071532,GO:0071625,GO:0097110,GO:2000311,GO:2000463 intracellular|cytosol|plasma membrane|protein complex assembly|cytoskeletal anchoring at plasma membrane|long-term memory|protein C-terminus binding|associative learning|postsynaptic density|membrane|SH3 domain binding|NMDA selective glutamate receptor complex|cell junction|GKAP/Homer scaffold activity|dendrite|adult behavior|somatostatin receptor binding|negative regulation of actin filament bundle assembly|protein complex binding|social behavior|ionotropic glutamate receptor binding|protein localization to synapse|olfactory behavior|identical protein binding|neuron projection|dendritic spine|postsynaptic membrane|habituation|neuromuscular process controlling balance|determination of affect|righting reflex|synapse maturation|excitatory synapse|dendritic spine morphogenesis|positive regulation of dendritic spine development|ankyrin repeat binding|vocalization behavior|scaffold protein binding|regulation of AMPA receptor activity|positive regulation of excitatory postsynaptic potential hsa04724 Glutamatergic synapse SHANK2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:22941,Genbank:NM_012309.4,HGNC:HGNC:14295,MIM:603290 SH3 and multiple ankyrin repeat domains 2 GO:0001750,GO:0001917,GO:0005829,GO:0005886,GO:0007416,GO:0007612,GO:0014069,GO:0016324,GO:0017124,GO:0030054,GO:0030160,GO:0030426,GO:0030534,GO:0031526,GO:0035176,GO:0035255,GO:0043005,GO:0043025,GO:0043197,GO:0045211,GO:0060170,GO:0060291,GO:0060292,GO:0071625 photoreceptor outer segment|photoreceptor inner segment|cytosol|plasma membrane|synapse assembly|learning|postsynaptic density|apical plasma membrane|SH3 domain binding|cell junction|GKAP/Homer scaffold activity|growth cone|adult behavior|brush border membrane|social behavior|ionotropic glutamate receptor binding|neuron projection|neuronal cell body|dendritic spine|postsynaptic membrane|ciliary membrane|long-term synaptic potentiation|long term synaptic depression|vocalization behavior hsa04724 Glutamatergic synapse SHANK3 59.7878975949791 57.5392507820043 62.0365444079539 1.07816044812589 0.108571890976164 0.814143711267681 1 0.315049 0.388452 0.423134 0.329885 GeneID:85358,Genbank:NM_033517.1,HGNC:HGNC:14294,MIM:606230 SH3 and multiple ankyrin repeat domains 3 GO:0000165,GO:0003779,GO:0005829,GO:0005886,GO:0007411,GO:0007416,GO:0007612,GO:0007613,GO:0008022,GO:0008270,GO:0014069,GO:0017124,GO:0021773,GO:0030054,GO:0030160,GO:0030534,GO:0032232,GO:0035176,GO:0035255,GO:0042297,GO:0043005,GO:0043197,GO:0043621,GO:0044309,GO:0045211,GO:0045794,GO:0048170,GO:0048854,GO:0051835,GO:0051968,GO:0060170,GO:0060997,GO:0060999,GO:0061001,GO:0071625,GO:0097107,GO:0097110,GO:0097113,GO:0097114,GO:0097117,GO:1900271,GO:1900273,GO:1900451,GO:1900452,GO:2000463,GO:2000969 MAPK cascade|actin binding|cytosol|plasma membrane|axon guidance|synapse assembly|learning|memory|protein C-terminus binding|zinc ion binding|postsynaptic density|SH3 domain binding|striatal medium spiny neuron differentiation|cell junction|GKAP/Homer scaffold activity|adult behavior|negative regulation of actin filament bundle assembly|social behavior|ionotropic glutamate receptor binding|vocal learning|neuron projection|dendritic spine|protein self-association|neuron spine|postsynaptic membrane|negative regulation of cell volume|positive regulation of long-term neuronal synaptic plasticity|brain morphogenesis|positive regulation of synapse structural plasticity|positive regulation of synaptic transmission, glutamatergic|ciliary membrane|dendritic spine morphogenesis|positive regulation of dendritic spine development|regulation of dendritic spine morphogenesis|vocalization behavior|postsynaptic density assembly|scaffold protein binding|AMPA glutamate receptor clustering|NMDA glutamate receptor clustering|guanylate kinase-associated protein clustering|regulation of long-term synaptic potentiation|positive regulation of long-term synaptic potentiation|positive regulation of glutamate receptor signaling pathway|regulation of long term synaptic depression|positive regulation of excitatory postsynaptic potential|positive regulation of AMPA receptor activity hsa04724 Glutamatergic synapse SHARPIN 824.934360174211 833.76970450603 816.099015842392 0.978806271602172 -0.0309047495179091 0.832052530669662 1 17.9452 16.7854 17.3957 16.1674 GeneID:81858,Genbank:NM_030974.3,HGNC:HGNC:25321,MIM:611885 SHANK associated RH domain interactor GO:0004842,GO:0005829,GO:0007005,GO:0007249,GO:0007420,GO:0010803,GO:0014069,GO:0030054,GO:0030262,GO:0030425,GO:0031424,GO:0031593,GO:0032403,GO:0042802,GO:0043123,GO:0043161,GO:0046872,GO:0050728,GO:0051260,GO:0071797,GO:0097039,GO:2000348 ubiquitin-protein transferase activity|cytosol|mitochondrion organization|I-kappaB kinase/NF-kappaB signaling|brain development|regulation of tumor necrosis factor-mediated signaling pathway|postsynaptic density|cell junction|apoptotic nuclear changes|dendrite|keratinization|polyubiquitin modification-dependent protein binding|protein complex binding|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|negative regulation of inflammatory response|protein homooligomerization|LUBAC complex|protein linear polyubiquitination|regulation of CD40 signaling pathway hsa04217,hsa04621 Necroptosis|NOD-like receptor signaling pathway SHB 1547.77277308885 1385.28196679825 1710.26357937945 1.23459600310276 0.30403902588131 0.0362158412891044 0.739837900620275 8.89372 8.73951 11.363 10.9865 GeneID:6461,Genbank:NM_003028.2,HGNC:HGNC:10838,MIM:600314 SH2 domain containing adaptor protein B GO:0001525,GO:0001784,GO:0005070,GO:0005654,GO:0005829,GO:0005886,GO:0006915,GO:0007165,GO:0030154,GO:0036464,GO:0048010 angiogenesis|phosphotyrosine residue binding|SH3/SH2 adaptor activity|nucleoplasm|cytosol|plasma membrane|apoptotic process|signal transduction|cell differentiation|cytoplasmic ribonucleoprotein granule|vascular endothelial growth factor receptor signaling pathway SHBG 10.663709835612 10.1856382366268 11.1417814345972 1.09387170207284 0.1294435373649 0.950076293124227 1 0.215505 0.0270389 0.172333 0.187947 GeneID:6462,Genbank:NM_001289114.1,HGNC:HGNC:10839,MIM:182205 sex hormone binding globulin SHC1 9586.7725345177 9343.55519588996 9829.98987314543 1.0520609839678 0.0732183345901959 0.590333005983888 1 73.7012 77.9694 81.5408 82.5652 GeneID:6464,Genbank:NM_001130041.1,HGNC:HGNC:10840,MIM:600560 SHC adaptor protein 1 hsa01521,hsa01522,hsa04012,hsa04014,hsa04062,hsa04072,hsa04510,hsa04650,hsa04722,hsa04910,hsa04915,hsa04917,hsa04926,hsa05034,hsa05100,hsa05206,hsa05214,hsa05220,hsa05224,hsa05225,hsa05226 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|Neurotrophin signaling pathway|Insulin signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Alcoholism|Bacterial invasion of epithelial cells|MicroRNAs in cancer|Glioma|Chronic myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer SHC2 261.568578361907 264.855003116765 258.282153607049 0.9751832155996 -0.0362547997122636 0.853511302064947 1 2.73267 3.00259 2.89603 3.41389 GeneID:25759,Genbank:NM_012435.2,HGNC:HGNC:29869,MIM:605217 SHC adaptor protein 2 GO:0000165,GO:0000187,GO:0005088,GO:0005829,GO:0005886,GO:0007169,GO:0007265,GO:0030971,GO:0048010 MAPK cascade|activation of MAPK activity|Ras guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|Ras protein signal transduction|receptor tyrosine kinase binding|vascular endothelial growth factor receptor signaling pathway hsa01521,hsa01522,hsa04012,hsa04014,hsa04062,hsa04072,hsa04370,hsa04510,hsa04650,hsa04722,hsa04910,hsa04915,hsa04917,hsa04926,hsa05034,hsa05100,hsa05214,hsa05220,hsa05224,hsa05225,hsa05226 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|VEGF signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|Neurotrophin signaling pathway|Insulin signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Alcoholism|Bacterial invasion of epithelial cells|Glioma|Chronic myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer SHC3 194.067590450522 204.451759162171 183.683421738873 0.898419375267762 -0.154539053723534 0.524610249467675 1 0.380978 0.340321 0.350758 0.319667 GeneID:53358,Genbank:NM_016848.5,HGNC:HGNC:18181,MIM:605263 SHC adaptor protein 3 GO:0000165,GO:0001784,GO:0004871,GO:0005088,GO:0005829,GO:0005886,GO:0007169,GO:0007173,GO:0007265,GO:0007411,GO:0007417,GO:0007611,GO:0030971,GO:0035249 MAPK cascade|phosphotyrosine residue binding|signal transducer activity|Ras guanyl-nucleotide exchange factor activity|cytosol|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal growth factor receptor signaling pathway|Ras protein signal transduction|axon guidance|central nervous system development|learning or memory|receptor tyrosine kinase binding|synaptic transmission, glutamatergic hsa01521,hsa01522,hsa04012,hsa04014,hsa04062,hsa04072,hsa04510,hsa04650,hsa04722,hsa04910,hsa04915,hsa04917,hsa04926,hsa05034,hsa05100,hsa05214,hsa05220,hsa05224,hsa05225,hsa05226 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|Neurotrophin signaling pathway|Insulin signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Alcoholism|Bacterial invasion of epithelial cells|Glioma|Chronic myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer SHC4 83.1978468024143 88.3745144848864 78.0211791199422 0.88284704673863 -0.179764582297496 0.59349308738892 1 0.690073 0.686116 0.566071 0.590694 GeneID:399694,Genbank:NM_203349.3,HGNC:HGNC:16743,MIM:617372 SHC adaptor protein 4 hsa01521,hsa01522,hsa04012,hsa04014,hsa04062,hsa04072,hsa04510,hsa04650,hsa04722,hsa04910,hsa04915,hsa04917,hsa04926,hsa05034,hsa05100,hsa05206,hsa05214,hsa05220,hsa05224,hsa05225,hsa05226 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|Phospholipase D signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|Neurotrophin signaling pathway|Insulin signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Alcoholism|Bacterial invasion of epithelial cells|MicroRNAs in cancer|Glioma|Chronic myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer SHCBP1 2662.99532632191 2759.71065116513 2566.28000147869 0.929909083184221 -0.104838423452751 0.464995301562712 1 18.4708 16.8958 18.6284 14.9586 GeneID:79801,Genbank:NM_001324318.1,HGNC:HGNC:29547,MIM:611027 SHC binding and spindle associated 1 GO:0005737,GO:0005819,GO:0008543,GO:0030496,GO:0042169,GO:2000177 cytoplasm|spindle|fibroblast growth factor receptor signaling pathway|midbody|SH2 domain binding|regulation of neural precursor cell proliferation SHD 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0 0 0.0200335 0.018815 GeneID:56961,Genbank:NM_020209.3,HGNC:HGNC:30633,MIM:610481 Src homology 2 domain containing transforming protein D GO:0005070,GO:0007165 SH3/SH2 adaptor activity|signal transduction SHE 1.50986585944834 1.56626675524197 1.45346496365472 0.927980472541008 -0.107833647793846 1 1 0.00898871 0.00418217 0.00428112 0.00798118 GeneID:126669,Genbank:XM_005244891.5,HGNC:HGNC:27004,MIM:610482 Src homology 2 domain containing E GO:0005070,GO:0007165 SH3/SH2 adaptor activity|signal transduction SHF 119.155084261181 102.13473135927 136.175437163092 1.33329216565989 0.414992954292424 0.134548389474528 1 0.674243 0.676918 0.818001 0.890553 GeneID:90525,Genbank:NM_138356.2,HGNC:HGNC:25116,MIM:617313 Src homology 2 domain containing F GO:0005070,GO:0006915,GO:0007165 SH3/SH2 adaptor activity|apoptotic process|signal transduction SHH 0.975139704544532 0.980142803914724 0.97013660517434 0.989791080748215 -0.0148040531050533 1 1 0 0.0085387 0.00902579 0 GeneID:6469,Genbank:NM_001310462.1,HGNC:HGNC:10848,MIM:600725 sonic hedgehog hsa04340,hsa04360,hsa05200,hsa05205,hsa05217,hsa05226 Hedgehog signaling pathway|Axon guidance|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Gastric cancer SHISA2 88.7700682901826 98.0602726644479 79.4798639159173 0.810520527389203 -0.303079370726794 0.352945760203514 1 2.01298 1.52106 1.59286 1.4659 GeneID:387914,Genbank:NM_001007538.1,HGNC:HGNC:20366,MIM:617324 shisa family member 2 GO:0005789,GO:0007275,GO:0016021,GO:0030178,GO:0040037 endoplasmic reticulum membrane|multicellular organism development|integral component of membrane|negative regulation of Wnt signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway SHISA4 564.71054305856 529.027829732834 600.393256384286 1.13489919176368 0.182564154783469 0.417514208648272 1 9.56994 10.6934 10.9536 12.8292 GeneID:149345,Genbank:NM_198149.2,HGNC:HGNC:27139,MIM:617326 shisa family member 4 GO:0016021 integral component of membrane SHISA5 5571.50293004088 5013.96630452035 6129.03955556141 1.22239344728658 0.289708714853701 0.261095121079101 1 58.0337 58.9338 88.5354 59.4238 GeneID:51246,Genbank:NM_001272066.1,HGNC:HGNC:30376,MIM:607290 shisa family member 5 GO:0004871,GO:0005788,GO:0005789,GO:0016021,GO:0031965,GO:0042771,GO:0043123,GO:0043687,GO:0044267,GO:0050699,GO:0070062 signal transducer activity|endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral component of membrane|nuclear membrane|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|positive regulation of I-kappaB kinase/NF-kappaB signaling|post-translational protein modification|cellular protein metabolic process|WW domain binding|extracellular exosome hsa04115 p53 signaling pathway SHISA8 57.3776416511164 58.0675398035387 56.6877434986941 0.976238078804219 -0.0346950687954026 0.962263369757063 1 0.455423 0.388879 0.311016 0.55679 GeneID:440829,Genbank:XM_006724256.4,HGNC:HGNC:18351,MIM:617329 shisa family member 8 GO:0032281,GO:0045202,GO:0048172 AMPA glutamate receptor complex|synapse|regulation of short-term neuronal synaptic plasticity SHISAL1 10.4659388037399 9.30154798208194 11.6303296253979 1.25036495514532 0.322349248592108 0.753252280192809 1 0.0545457 0.0436279 0.0627322 0.069236 GeneID:85352,Genbank:XM_005261790.3,HGNC:HGNC:29335 shisa like 1 GO:0016021 integral component of membrane SHKBP1 1858.1931835945 1762.85339236521 1953.53297482379 1.10816530931296 0.148173109849938 0.317600663649952 1 24.1461 28.1677 29.5995 29.3102 GeneID:92799,Genbank:NM_138392.3,HGNC:HGNC:19214,MIM:617322 SH3KBP1 binding protein 1 GO:0005764,GO:0045742,GO:0051260 lysosome|positive regulation of epidermal growth factor receptor signaling pathway|protein homooligomerization SHMT1 2646.21169869859 2559.23155749672 2733.19183990046 1.06797363915515 0.0948760373536523 0.498451837717961 1 33.1778 34.0014 35.8248 37.1918 GeneID:6470,Genbank:NM_001281786.1,HGNC:HGNC:10850,MIM:182144 serine hydroxymethyltransferase 1 GO:0000900,GO:0004372,GO:0005634,GO:0005739,GO:0005829,GO:0006231,GO:0006544,GO:0006563,GO:0006565,GO:0008732,GO:0009113,GO:0017148,GO:0019264,GO:0030170,GO:0035999,GO:0042802,GO:0042803,GO:0045329,GO:0046653,GO:0046655,GO:0048027,GO:0051262,GO:0051289,GO:0070062,GO:0070905,GO:1904482,GO:1990830 translation repressor activity, nucleic acid binding|glycine hydroxymethyltransferase activity|nucleus|mitochondrion|cytosol|dTMP biosynthetic process|glycine metabolic process|L-serine metabolic process|L-serine catabolic process|L-allo-threonine aldolase activity|purine nucleobase biosynthetic process|negative regulation of translation|glycine biosynthetic process from serine|pyridoxal phosphate binding|tetrahydrofolate interconversion|identical protein binding|protein homodimerization activity|carnitine biosynthetic process|tetrahydrofolate metabolic process|folic acid metabolic process|mRNA 5'-UTR binding|protein tetramerization|protein homotetramerization|extracellular exosome|serine binding|cellular response to tetrahydrofolate|cellular response to leukemia inhibitory factor hsa00260,hsa00630,hsa00670,hsa01523 Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism|One carbon pool by folate|Antifolate resistance SHMT2 4803.77910723761 4988.50322592964 4619.05498854558 0.92594006244925 -0.111009286289421 0.51735074858738 1 55.4707 59.5341 48.8409 58.2638 GeneID:6472,Genbank:NM_005412.5,HGNC:HGNC:10852,MIM:138450 serine hydroxymethyltransferase 2 GO:0003682,GO:0004372,GO:0005634,GO:0005737,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0006544,GO:0006563,GO:0006564,GO:0006730,GO:0008284,GO:0008732,GO:0015630,GO:0016597,GO:0019264,GO:0030170,GO:0034340,GO:0035999,GO:0042645,GO:0042802,GO:0046653,GO:0046655,GO:0051262,GO:0051289,GO:0070062,GO:0070536,GO:0070552 chromatin binding|glycine hydroxymethyltransferase activity|nucleus|cytoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|glycine metabolic process|L-serine metabolic process|L-serine biosynthetic process|one-carbon metabolic process|positive regulation of cell proliferation|L-allo-threonine aldolase activity|microtubule cytoskeleton|amino acid binding|glycine biosynthetic process from serine|pyridoxal phosphate binding|response to type I interferon|tetrahydrofolate interconversion|mitochondrial nucleoid|identical protein binding|tetrahydrofolate metabolic process|folic acid metabolic process|protein tetramerization|protein homotetramerization|extracellular exosome|protein K63-linked deubiquitination|BRISC complex hsa00260,hsa00630,hsa00670,hsa01523 Glycine, serine and threonine metabolism|Glyoxylate and dicarboxylate metabolism|One carbon pool by folate|Antifolate resistance SHOC2 322.581052563765 336.902256857041 308.259848270489 0.914983031417607 -0.128183106372285 0.732025133474095 1 3.57716 2.62081 3.24732 2.41795 GeneID:8036,Genbank:NM_001324336.1,HGNC:HGNC:15454,MIM:602775 SHOC2, leucine rich repeat scaffold protein hsa04014 Ras signaling pathway SHOX2 398.57204522022 385.198811587611 411.945278852828 1.06943548749535 0.0968494561563459 0.61233784235963 1 3.22445 3.41895 3.63132 3.36964 GeneID:6474,Genbank:XM_006713727.3,HGNC:HGNC:10854,MIM:602504 short stature homeobox 2 GO:0000122,GO:0001501,GO:0001649,GO:0002053,GO:0002063,GO:0003170,GO:0003209,GO:0005634,GO:0007399,GO:0007507,GO:0032330,GO:0035115,GO:0043565,GO:0045880,GO:0045944,GO:0048557,GO:0048743,GO:0050772,GO:0060272,GO:0060351,GO:0060415,GO:2000172 negative regulation of transcription from RNA polymerase II promoter|skeletal system development|osteoblast differentiation|positive regulation of mesenchymal cell proliferation|chondrocyte development|heart valve development|cardiac atrium morphogenesis|nucleus|nervous system development|heart development|regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|sequence-specific DNA binding|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter|embryonic digestive tract morphogenesis|positive regulation of skeletal muscle fiber development|positive regulation of axonogenesis|embryonic skeletal joint morphogenesis|cartilage development involved in endochondral bone morphogenesis|muscle tissue morphogenesis|regulation of branching morphogenesis of a nerve SHPK 477.187465654119 473.65956996676 480.715361341478 1.01489633446066 0.0213323723390577 0.90674198189182 1 5.57922 5.53531 5.47777 6.0719 GeneID:23729,Genbank:NM_013276.2,HGNC:HGNC:1492,MIM:605060 sedoheptulokinase GO:0005524,GO:0005737,GO:0005829,GO:0005975,GO:0006098,GO:0009052,GO:0016310,GO:0035963,GO:0043030,GO:0050277,GO:0050727,GO:0071222,GO:0071353 ATP binding|cytoplasm|cytosol|carbohydrate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|phosphorylation|cellular response to interleukin-13|regulation of macrophage activation|sedoheptulokinase activity|regulation of inflammatory response|cellular response to lipopolysaccharide|cellular response to interleukin-4 SHPRH 158.895096342641 164.621705434678 153.168487250604 0.930427046944801 -0.104035059204799 0.86119135115432 1 0.439237 0.264986 0.398255 0.241704 GeneID:257218,Genbank:XM_006715439.4,HGNC:HGNC:19336,MIM:608048 SNF2 histone linker PHD RING helicase GO:0000209,GO:0000786,GO:0003677,GO:0004386,GO:0004842,GO:0005524,GO:0005654,GO:0006281,GO:0006334,GO:0006974,GO:0016567,GO:0031625,GO:0046872,GO:0061630 protein polyubiquitination|nucleosome|DNA binding|helicase activity|ubiquitin-protein transferase activity|ATP binding|nucleoplasm|DNA repair|nucleosome assembly|cellular response to DNA damage stimulus|protein ubiquitination|ubiquitin protein ligase binding|metal ion binding|ubiquitin protein ligase activity SHQ1 537.812614497187 537.204139086091 538.421089908283 1.00226534148501 0.00326450071637461 0.982667810086078 1 2.91698 2.88681 3.10215 2.96036 GeneID:55164,Genbank:NM_018130.2,HGNC:HGNC:25543,MIM:613663 SHQ1, H/ACA ribonucleoprotein assembly factor GO:0000493,GO:0005654,GO:0005737,GO:0005829,GO:0022618,GO:0043065,GO:0051082,GO:1904874,GO:2000233 box H/ACA snoRNP assembly|nucleoplasm|cytoplasm|cytosol|ribonucleoprotein complex assembly|positive regulation of apoptotic process|unfolded protein binding|positive regulation of telomerase RNA localization to Cajal body|negative regulation of rRNA processing SHROOM1 335.227562863266 334.626421637488 335.828704089045 1.00359290950689 0.00517418309827813 1 1 2.52761 2.62723 2.57458 2.87467 GeneID:134549,Genbank:XM_011543167.3,HGNC:HGNC:24084,MIM:611179 shroom family member 1 GO:0000902,GO:0005737,GO:0005874,GO:0016460,GO:0051015,GO:0051017 cell morphogenesis|cytoplasm|microtubule|myosin II complex|actin filament binding|actin filament bundle assembly SHROOM2 74.776836227237 80.2550230605669 69.2986493939071 0.8634805243481 -0.211764456500016 0.530619548230759 1 0.352873 0.398376 0.308529 0.334709 GeneID:357,Genbank:XM_005274500.4,HGNC:HGNC:630,MIM:300103 shroom family member 2 GO:0002089,GO:0003779,GO:0005737,GO:0005856,GO:0005874,GO:0005886,GO:0005913,GO:0005923,GO:0007420,GO:0008013,GO:0008057,GO:0015280,GO:0016324,GO:0016477,GO:0032401,GO:0032438,GO:0043010,GO:0043482,GO:0043583,GO:0045176,GO:0048593,GO:0051015,GO:0070062 lens morphogenesis in camera-type eye|actin binding|cytoplasm|cytoskeleton|microtubule|plasma membrane|cell-cell adherens junction|bicellular tight junction|brain development|beta-catenin binding|eye pigment granule organization|ligand-gated sodium channel activity|apical plasma membrane|cell migration|establishment of melanosome localization|melanosome organization|camera-type eye development|cellular pigment accumulation|ear development|apical protein localization|camera-type eye morphogenesis|actin filament binding|extracellular exosome SHROOM3 1552.63000276524 1519.50064500221 1585.75936052827 1.04360558565341 0.0615765709745036 0.67060189338978 1 2.7964 2.88366 3.20131 2.79953 GeneID:57619,Genbank:NM_020859.3,HGNC:HGNC:30422,MIM:604570 shroom family member 3 GO:0000902,GO:0001843,GO:0002064,GO:0005737,GO:0005856,GO:0005874,GO:0005912,GO:0007389,GO:0008360,GO:0016324,GO:0043296,GO:0043482,GO:0045176,GO:0051015 cell morphogenesis|neural tube closure|epithelial cell development|cytoplasm|cytoskeleton|microtubule|adherens junction|pattern specification process|regulation of cell shape|apical plasma membrane|apical junction complex|cellular pigment accumulation|apical protein localization|actin filament binding SHROOM4 125.849070828941 120.343808470846 131.354333187036 1.09149224090625 0.126301874675138 0.642329080657958 1 0.397202 0.358908 0.509687 0.328488 GeneID:57477,Genbank:NM_020717.3,HGNC:HGNC:29215,MIM:300579 shroom family member 4 GO:0001725,GO:0005737,GO:0007015,GO:0007420,GO:0009898,GO:0009925,GO:0016324,GO:0016460,GO:0030036,GO:0030864,GO:0050890,GO:0051015 stress fiber|cytoplasm|actin filament organization|brain development|cytoplasmic side of plasma membrane|basal plasma membrane|apical plasma membrane|myosin II complex|actin cytoskeleton organization|cortical actin cytoskeleton|cognition|actin filament binding SHTN1 1010.78294055467 944.108137182172 1077.45774392716 1.14124399684023 0.190607271380045 0.396438582422364 1 2.74969 2.40381 3.47212 2.48781 GeneID:57698,Genbank:NM_001258298.1,HGNC:HGNC:29319,MIM:611171 shootin 1 GO:0005737,GO:0005874,GO:0005875,GO:0006930,GO:0007265,GO:0007409,GO:0015630,GO:0019894,GO:0030027,GO:0030175,GO:0030424,GO:0030426,GO:0031252,GO:0032488,GO:0038007,GO:0043204,GO:0044295,GO:0045296,GO:0045773,GO:0048471,GO:0048812,GO:0051015,GO:0060327,GO:0061163,GO:0061573,GO:2000114,GO:2001224 cytoplasm|microtubule|microtubule associated complex|substrate-dependent cell migration, cell extension|Ras protein signal transduction|axonogenesis|microtubule cytoskeleton|kinesin binding|lamellipodium|filopodium|axon|growth cone|cell leading edge|Cdc42 protein signal transduction|netrin-activated signaling pathway|perikaryon|axonal growth cone|cadherin binding|positive regulation of axon extension|perinuclear region of cytoplasm|neuron projection morphogenesis|actin filament binding|cytoplasmic actin-based contraction involved in cell motility|endoplasmic reticulum polarization|actin filament bundle retrograde transport|regulation of establishment of cell polarity|positive regulation of neuron migration SIAE 151.270098868689 138.264727934313 164.275469803065 1.1881227573898 0.248683903754901 0.322244131619864 1 0.952396 0.921423 1.03092 1.13102 GeneID:54414,Genbank:NM_001199922.1,HGNC:HGNC:18187,MIM:610079 sialic acid acetylesterase GO:0001681,GO:0002682,GO:0005615,GO:0005764,GO:0005975,GO:0070062 sialate O-acetylesterase activity|regulation of immune system process|extracellular space|lysosome|carbohydrate metabolic process|extracellular exosome SIAH1 532.878702798777 566.156569421153 499.600836176402 0.882442884460745 -0.18042519097588 0.294296496486235 1 2.19332 2.29561 1.86975 2.2205 GeneID:6477,Genbank:XM_011523279.2,HGNC:HGNC:10857,MIM:602212 siah E3 ubiquitin protein ligase 1 GO:0000209,GO:0004842,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0005886,GO:0006511,GO:0006915,GO:0007049,GO:0007283,GO:0007399,GO:0007411,GO:0008022,GO:0008270,GO:0009653,GO:0030163,GO:0030877,GO:0031648,GO:0042787,GO:0042802,GO:0043065,GO:0043161,GO:0044267,GO:0051402,GO:0061630,GO:2001244 protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|cytoplasm|early endosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|apoptotic process|cell cycle|spermatogenesis|nervous system development|axon guidance|protein C-terminus binding|zinc ion binding|anatomical structure morphogenesis|protein catabolic process|beta-catenin destruction complex|protein destabilization|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|identical protein binding|positive regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|cellular protein metabolic process|neuron apoptotic process|ubiquitin protein ligase activity|positive regulation of intrinsic apoptotic signaling pathway hsa04115,hsa04120,hsa04310 p53 signaling pathway|Ubiquitin mediated proteolysis|Wnt signaling pathway SIAH2 438.505239524735 398.670870813885 478.339608235586 1.19983586274828 0.262837059004267 0.150209808701173 1 9.16062 9.92901 12.0976 10.8367 GeneID:6478,Genbank:NM_005067.6,HGNC:HGNC:10858,MIM:602213 siah E3 ubiquitin protein ligase 2 SIDT1 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.00828606 0 GeneID:54847,Genbank:XM_017006665.2,HGNC:HGNC:25967,MIM:606816 SID1 transmembrane family member 1 GO:0003723,GO:0016021,GO:0033227,GO:0051033 RNA binding|integral component of membrane|dsRNA transport|RNA transmembrane transporter activity SIDT2 376.683435165637 351.605415916617 401.761454414658 1.14264865166336 0.192381863372655 0.309374690751713 1 3.48042 3.68731 4.12306 3.90608 GeneID:51092,Genbank:NM_001040455.1,HGNC:HGNC:24272,MIM:617551 SID1 transmembrane family member 2 GO:0000902,GO:0003323,GO:0003677,GO:0003725,GO:0005764,GO:0005765,GO:0005886,GO:0006401,GO:0009749,GO:0016021,GO:0033227,GO:0035612,GO:0035650,GO:0042593,GO:0044342,GO:0050658,GO:0051032,GO:0051033,GO:0061178 cell morphogenesis|type B pancreatic cell development|DNA binding|double-stranded RNA binding|lysosome|lysosomal membrane|plasma membrane|RNA catabolic process|response to glucose|integral component of membrane|dsRNA transport|AP-2 adaptor complex binding|AP-1 adaptor complex binding|glucose homeostasis|type B pancreatic cell proliferation|RNA transport|nucleic acid transmembrane transporter activity|RNA transmembrane transporter activity|regulation of insulin secretion involved in cellular response to glucose stimulus SIGIRR 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:59307,Genbank:XM_005253046.1,HGNC:HGNC:30575,MIM:605478 single Ig and TIR domain containing GO:0001960,GO:0005886,GO:0006953,GO:0007165,GO:0016020,GO:0016021,GO:0031665,GO:0043433,GO:0045079,GO:0071345 negative regulation of cytokine-mediated signaling pathway|plasma membrane|acute-phase response|signal transduction|membrane|integral component of membrane|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of DNA binding transcription factor activity|negative regulation of chemokine biosynthetic process|cellular response to cytokine stimulus SIGLEC1 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.00564546 0.00493209 0 0 GeneID:6614,Genbank:XM_011529325.2,HGNC:HGNC:11127,MIM:600751 sialic acid binding Ig like lectin 1 hsa04514 Cell adhesion molecules (CAMs) SIGLEC10 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:89790,Genbank:NM_001171161.1,HGNC:HGNC:15620,MIM:606091 sialic acid binding Ig like lectin 10 SIGLEC16 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0113016 0 GeneID:400709,Genbank:NM_001348364.1,HGNC:HGNC:24851 sialic acid binding Ig like lectin 16 (gene/pseudogene) GO:0005886,GO:0007155,GO:0016021,GO:0030246,GO:0045087 plasma membrane|cell adhesion|integral component of membrane|carbohydrate binding|innate immune response SIGLEC5 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0125325 0 GeneID:8778,Genbank:XM_017027419.1,HGNC:HGNC:10874,MIM:604200 sialic acid binding Ig like lectin 5 SIGMAR1 1008.6853926915 998.661984280311 1018.7088011027 1.02007367571605 0.0286733558747915 0.882165876451868 1 21.1925 23.849 24.485 22.1429 GeneID:10280,Genbank:NM_001282207.1,HGNC:HGNC:8157,MIM:601978 sigma non-opioid intracellular receptor 1 SIK1 3.26520240590207 3.6226049124413 2.90779989936283 0.802682039483913 -0.317099478131647 0.956951145867269 1 0.0366627 0.0322452 0.0228026 0.0319041 GeneID:150094,Genbank:XM_011529474.2,HGNC:HGNC:11142,MIM:605705 salt inducible kinase 1 GO:0000287,GO:0002028,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007049,GO:0007346,GO:0008140,GO:0010830,GO:0010868,GO:0019901,GO:0032792,GO:0032870,GO:0035556,GO:0043153,GO:0045595,GO:0045721,GO:0046777,GO:0048511,GO:0055007,GO:0071889,GO:2000210 magnesium ion binding|regulation of sodium ion transport|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|cell cycle|regulation of mitotic cell cycle|cAMP response element binding protein binding|regulation of myotube differentiation|negative regulation of triglyceride biosynthetic process|protein kinase binding|negative regulation of CREB transcription factor activity|cellular response to hormone stimulus|intracellular signal transduction|entrainment of circadian clock by photoperiod|regulation of cell differentiation|negative regulation of gluconeogenesis|protein autophosphorylation|rhythmic process|cardiac muscle cell differentiation|14-3-3 protein binding|positive regulation of anoikis hsa04922 Glucagon signaling pathway SIK1B 153.672545419595 166.285041740144 141.060049099046 0.848302695316892 -0.237348949071557 0.493462846877684 1 1.75141 1.82968 2.00705 1.14214 GeneID:102724428,Genbank:NM_001320643.2,HGNC:HGNC:52389 salt inducible kinase 1B (putative) GO:0000287,GO:0002028,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007049,GO:0007346,GO:0008140,GO:0010830,GO:0010868,GO:0019901,GO:0032792,GO:0032870,GO:0035556,GO:0043153,GO:0045595,GO:0045721,GO:0046777,GO:0048511,GO:0055007,GO:0071889,GO:2000210 magnesium ion binding|regulation of sodium ion transport|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|cell cycle|regulation of mitotic cell cycle|cAMP response element binding protein binding|regulation of myotube differentiation|negative regulation of triglyceride biosynthetic process|protein kinase binding|negative regulation of CREB transcription factor activity|cellular response to hormone stimulus|intracellular signal transduction|entrainment of circadian clock by photoperiod|regulation of cell differentiation|negative regulation of gluconeogenesis|protein autophosphorylation|rhythmic process|cardiac muscle cell differentiation|14-3-3 protein binding|positive regulation of anoikis hsa04922 Glucagon signaling pathway SIK2 1365.38042768801 1328.57877999611 1402.18207537991 1.05540002331214 0.0777899205105489 0.652740907374292 1 8.15505 8.51388 10.2212 7.59337 GeneID:23235,Genbank:NM_015191.2,HGNC:HGNC:21680,MIM:608973 salt inducible kinase 2 GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0032870,GO:0035556,GO:0046626,GO:0046777 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|cellular response to hormone stimulus|intracellular signal transduction|regulation of insulin receptor signaling pathway|protein autophosphorylation hsa04922 Glucagon signaling pathway SIK3 567.967733410956 598.491473295231 537.443993526682 0.89799774517684 -0.155216272444632 0.352401707654927 1 2.26156 2.47764 2.12796 2.11519 GeneID:23387,Genbank:NM_001281749.1,HGNC:HGNC:29165,MIM:614776 SIK family kinase 3 GO:0000287,GO:0004674,GO:0005524,GO:0005737,GO:0006468 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|cytoplasm|protein phosphorylation SIKE1 582.625616686511 657.306799182658 507.944434190364 0.772766134203965 -0.371896224169369 0.100525343187138 1 5.2486 4.41143 4.35575 3.03831 GeneID:80143,Genbank:NM_025073.2,HGNC:HGNC:26119,MIM:611656 suppressor of IKBKE 1 GO:0005829,GO:0017048,GO:0019901 cytosol|Rho GTPase binding|protein kinase binding hsa04622 RIG-I-like receptor signaling pathway SIL1 816.530070072809 729.262068376983 903.798071768636 1.23933234835605 0.309563122933973 0.0548406989879965 0.853574961119292 9.28693 11.147 13.4224 13.4848 GeneID:64374,Genbank:NM_022464.4,HGNC:HGNC:24624,MIM:608005 SIL1 nucleotide exchange factor GO:0005615,GO:0005783,GO:0005788,GO:0006457,GO:0006886,GO:0051082 extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|intracellular protein transport|unfolded protein binding hsa04141 Protein processing in endoplasmic reticulum SIM2 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.0135147 0 0 GeneID:6493,Genbank:XM_017028442.2,HGNC:HGNC:10883,MIM:600892 single-minded family bHLH transcription factor 2 GO:0000122,GO:0000981,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0007399,GO:0009880,GO:0016604,GO:0030154,GO:0030324,GO:0046982 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|nervous system development|embryonic pattern specification|nuclear body|cell differentiation|lung development|protein heterodimerization activity SIMC1 67.7547284358438 71.5395990298122 63.9698578418754 0.894188095955329 -0.16134975502395 0.650036213331191 1 0.221187 0.275977 0.211416 0.223195 GeneID:375484,Genbank:NM_001308196.1,HGNC:HGNC:24779 SUMO interacting motifs containing 1 GO:0032184 SUMO polymer binding SIN3A 1419.10857459027 1430.78892959368 1407.42821958687 0.983672846830422 -0.0237495158405015 0.884855325608425 1 6.62113 6.32384 6.95128 5.94589 GeneID:25942,Genbank:XM_006720465.3,HGNC:HGNC:19353,MIM:607776 SIN3 transcription regulator family member A GO:0000122,GO:0000776,GO:0000976,GO:0001102,GO:0001103,GO:0001106,GO:0001701,GO:0002218,GO:0002230,GO:0002244,GO:0003682,GO:0003700,GO:0003723,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0006260,GO:0006351,GO:0006476,GO:0007568,GO:0010817,GO:0010971,GO:0016575,GO:0016580,GO:0017053,GO:0019216,GO:0031937,GO:0032403,GO:0033558,GO:0034613,GO:0042754,GO:0043066,GO:0043619,GO:0045652,GO:0045892,GO:0045944,GO:0048511,GO:0051595,GO:0071333,GO:1900181,GO:1901675,GO:1903351,GO:2000678 negative regulation of transcription from RNA polymerase II promoter|kinetochore|transcription regulatory region sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|RNA polymerase II repressing transcription factor binding|RNA polymerase II transcription corepressor activity|in utero embryonic development|activation of innate immune response|positive regulation of defense response to virus by host|hematopoietic progenitor cell differentiation|chromatin binding|DNA binding transcription factor activity|RNA binding|nucleus|nucleoplasm|transcription factor complex|nucleolus|DNA replication|transcription, DNA-templated|protein deacetylation|aging|regulation of hormone levels|positive regulation of G2/M transition of mitotic cell cycle|histone deacetylation|Sin3 complex|transcriptional repressor complex|regulation of lipid metabolic process|positive regulation of chromatin silencing|protein complex binding|protein deacetylase activity|cellular protein localization|negative regulation of circadian rhythm|negative regulation of apoptotic process|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|regulation of megakaryocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|rhythmic process|response to methylglyoxal|cellular response to glucose stimulus|negative regulation of protein localization to nucleus|negative regulation of histone H3-K27 acetylation|cellular response to dopamine|negative regulation of transcription regulatory region DNA binding hsa04919,hsa05016,hsa05169,hsa05202 Thyroid hormone signaling pathway|Huntington disease|Epstein-Barr virus infection|Transcriptional misregulation in cancer SIN3B 1553.43926873146 1490.6747101827 1616.20382728021 1.08420959733202 0.116643682707792 0.431386103067708 1 9.27708 9.59559 10.4229 10.4923 GeneID:23309,Genbank:NM_015260.3,HGNC:HGNC:19354,MIM:607777 SIN3 transcription regulator family member B GO:0000122,GO:0000805,GO:0000806,GO:0001106,GO:0001741,GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0016575,GO:0016580,GO:0019216,GO:0030849 negative regulation of transcription from RNA polymerase II promoter|X chromosome|Y chromosome|RNA polymerase II transcription corepressor activity|XY body|chromatin binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|histone deacetylation|Sin3 complex|regulation of lipid metabolic process|autosome SINHCAF 1286.82213179474 1397.98560562957 1175.65865795991 0.840966211115218 -0.249880258777685 0.0862126368010618 0.964561165794104 14.7258 17.1376 13.337 13.9596 GeneID:58516,Genbank:NM_001135812.1,HGNC:HGNC:30702,MIM:615027 SIN3-HDAC complex associated factor GO:0008284,GO:0016580,GO:0030336,GO:0045596 positive regulation of cell proliferation|Sin3 complex|negative regulation of cell migration|negative regulation of cell differentiation SIPA1 484.741227365713 471.315074161451 498.167380569975 1.05697315422448 0.0799387345644461 0.654274431974741 1 5.58061 5.29716 5.57616 6.13846 GeneID:6494,Genbank:NM_006747.3,HGNC:HGNC:10885,MIM:602180 signal-induced proliferation-associated 1 hsa04015,hsa04670 Rap1 signaling pathway|Leukocyte transendothelial migration SIPA1L1 950.006051844025 818.73036152366 1081.28174216439 1.32068113383767 0.401282183343855 0.00884824693265472 0.366376097193275 2.40721 2.40487 3.49684 2.94467 GeneID:26037,Genbank:XM_017021180.1,HGNC:HGNC:20284,MIM:617504 signal induced proliferation associated 1 like 1 GO:0005096,GO:0005737,GO:0005856,GO:0014069,GO:0030054,GO:0031532,GO:0043087,GO:0043197,GO:0045211,GO:0046875,GO:0048013,GO:0048167,GO:0050770,GO:0051056,GO:0061001,GO:0090630 GTPase activator activity|cytoplasm|cytoskeleton|postsynaptic density|cell junction|actin cytoskeleton reorganization|regulation of GTPase activity|dendritic spine|postsynaptic membrane|ephrin receptor binding|ephrin receptor signaling pathway|regulation of synaptic plasticity|regulation of axonogenesis|regulation of small GTPase mediated signal transduction|regulation of dendritic spine morphogenesis|activation of GTPase activity hsa04015 Rap1 signaling pathway SIPA1L2 792.753360826411 683.992185952419 901.514535700404 1.31801876427155 0.398370909745669 0.0462311908521265 0.79332376136203 3.26123 3.16292 4.90905 3.6203 GeneID:57568,Genbank:XM_017001896.1,HGNC:HGNC:23800,MIM:611609 signal induced proliferation associated 1 like 2 GO:0005096,GO:0051056 GTPase activator activity|regulation of small GTPase mediated signal transduction hsa04015 Rap1 signaling pathway SIPA1L3 1325.01504171042 1336.61202752617 1313.41805589467 0.982647192189025 -0.025254567886601 0.855476425504754 1 5.27542 5.2724 5.67774 4.82483 GeneID:23094,Genbank:XM_017026518.2,HGNC:HGNC:23801,MIM:616655 signal induced proliferation associated 1 like 3 GO:0001654,GO:0001725,GO:0002244,GO:0003382,GO:0005096,GO:0005615,GO:0007010,GO:0016324,GO:0045177,GO:0051056,GO:0061689,GO:0090162 eye development|stress fiber|hematopoietic progenitor cell differentiation|epithelial cell morphogenesis|GTPase activator activity|extracellular space|cytoskeleton organization|apical plasma membrane|apical part of cell|regulation of small GTPase mediated signal transduction|tricellular tight junction|establishment of epithelial cell polarity hsa04015 Rap1 signaling pathway SIRPA 828.574639524056 768.303067398446 888.846211649667 1.15689530520735 0.210258311729444 0.188808140286498 1 5.01388 5.4486 6.71457 5.78342 GeneID:140885,Genbank:NM_001330728.1,HGNC:HGNC:9662,MIM:602461 signal regulatory protein alpha GO:0005886,GO:0007155,GO:0016020,GO:0016021,GO:0017124,GO:0043312,GO:0050900,GO:0070062,GO:0070821,GO:0101003 plasma membrane|cell adhesion|membrane|integral component of membrane|SH3 domain binding|neutrophil degranulation|leukocyte migration|extracellular exosome|tertiary granule membrane|ficolin-1-rich granule membrane hsa04380 Osteoclast differentiation SIRPB1 3.40374437274378 1.96028560782945 4.84720313765811 2.47270250737863 1.30608867848779 0.513881872744677 1 0 0.0152341 0.0368032 0.0147952 GeneID:10326,Genbank:XM_017027577.1,HGNC:HGNC:15928,MIM:603889 signal regulatory protein beta 1 GO:0005886,GO:0005887,GO:0007165,GO:0007166,GO:0030667,GO:0043312,GO:0045087,GO:0070062 plasma membrane|integral component of plasma membrane|signal transduction|cell surface receptor signaling pathway|secretory granule membrane|neutrophil degranulation|innate immune response|extracellular exosome hsa04380 Osteoclast differentiation SIRT1 379.442093074372 413.774806378592 345.109379770153 0.834051214453081 -0.261792120607177 0.435438882555483 1 4.12393 3.18976 3.58509 2.42023 GeneID:23411,Genbank:NM_012238.4,HGNC:HGNC:14929,MIM:604479 sirtuin 1 hsa04068,hsa04152,hsa04211,hsa04213,hsa04218,hsa04922,hsa05031,hsa05206 FoxO signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Longevity regulating pathway - multiple species|Cellular senescence|Glucagon signaling pathway|Amphetamine addiction|MicroRNAs in cancer SIRT2 1777.9448602487 1530.78412990405 2025.10559059334 1.32292042426666 0.403726283862549 0.0373590533930928 0.744556882325193 14.8691 16.7813 20.211 23.6239 GeneID:22933,Genbank:NM_001193286.1,HGNC:HGNC:10886,MIM:604480 sirtuin 2 GO:0000122,GO:0000183,GO:0000781,GO:0003682,GO:0004407,GO:0005634,GO:0005677,GO:0005694,GO:0005720,GO:0005730,GO:0005737,GO:0005739,GO:0005813,GO:0005814,GO:0005819,GO:0005829,GO:0005874,GO:0005886,GO:0006342,GO:0006348,GO:0006351,GO:0006471,GO:0006476,GO:0006914,GO:0007096,GO:0008134,GO:0008270,GO:0008285,GO:0010507,GO:0010801,GO:0014065,GO:0016458,GO:0016575,GO:0017136,GO:0021762,GO:0022011,GO:0030426,GO:0030496,GO:0031641,GO:0032436,GO:0033010,GO:0033270,GO:0033558,GO:0034599,GO:0034979,GO:0034983,GO:0035035,GO:0035729,GO:0042177,GO:0042325,GO:0042826,GO:0042903,GO:0043130,GO:0043161,GO:0043204,GO:0043209,GO:0043219,GO:0043220,GO:0043388,GO:0043491,GO:0044224,GO:0044242,GO:0045087,GO:0045599,GO:0045836,GO:0045843,GO:0045892,GO:0045944,GO:0046970,GO:0048012,GO:0048471,GO:0051301,GO:0051321,GO:0051726,GO:0051775,GO:0051781,GO:0051987,GO:0061428,GO:0061433,GO:0070403,GO:0070446,GO:0070932,GO:0070933,GO:0071219,GO:0071456,GO:0071872,GO:0072686,GO:0072687,GO:0090042,GO:0097386,GO:1900119,GO:1900195,GO:1900226,GO:1900425,GO:2000378,GO:2000777 negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromosome, telomeric region|chromatin binding|histone deacetylase activity|nucleus|chromatin silencing complex|chromosome|nuclear heterochromatin|nucleolus|cytoplasm|mitochondrion|centrosome|centriole|spindle|cytosol|microtubule|plasma membrane|chromatin silencing|chromatin silencing at telomere|transcription, DNA-templated|protein ADP-ribosylation|protein deacetylation|autophagy|regulation of exit from mitosis|transcription factor binding|zinc ion binding|negative regulation of cell proliferation|negative regulation of autophagy|negative regulation of peptidyl-threonine phosphorylation|phosphatidylinositol 3-kinase signaling|gene silencing|histone deacetylation|NAD-dependent histone deacetylase activity|substantia nigra development|myelination in peripheral nervous system|growth cone|midbody|regulation of myelination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|paranodal junction|paranode region of axon|protein deacetylase activity|cellular response to oxidative stress|NAD-dependent protein deacetylase activity|peptidyl-lysine deacetylation|histone acetyltransferase binding|cellular response to hepatocyte growth factor stimulus|negative regulation of protein catabolic process|regulation of phosphorylation|histone deacetylase binding|tubulin deacetylase activity|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|perikaryon|myelin sheath|lateral loop|Schmidt-Lanterman incisure|positive regulation of DNA binding|protein kinase B signaling|juxtaparanode region of axon|cellular lipid catabolic process|innate immune response|negative regulation of fat cell differentiation|positive regulation of meiotic nuclear division|negative regulation of striated muscle tissue development|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|NAD-dependent histone deacetylase activity (H4-K16 specific)|hepatocyte growth factor receptor signaling pathway|perinuclear region of cytoplasm|cell division|meiotic cell cycle|regulation of cell cycle|response to redox state|positive regulation of cell division|positive regulation of attachment of spindle microtubules to kinetochore|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to caloric restriction|NAD+ binding|negative regulation of oligodendrocyte progenitor proliferation|histone H3 deacetylation|histone H4 deacetylation|cellular response to molecule of bacterial origin|cellular response to hypoxia|cellular response to epinephrine stimulus|mitotic spindle|meiotic spindle|tubulin deacetylation|glial cell projection|positive regulation of execution phase of apoptosis|positive regulation of oocyte maturation|negative regulation of NLRP3 inflammasome complex assembly|negative regulation of defense response to bacterium|negative regulation of reactive oxygen species metabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia SIRT3 257.98897654054 230.559813634858 285.418139446222 1.23793533203598 0.307935952203407 0.1401117403912 1 1.78492 1.82726 2.08524 2.47089 GeneID:23410,Genbank:NM_001017524.2,HGNC:HGNC:14931,MIM:604481 sirtuin 3 GO:0003950,GO:0005739,GO:0005759,GO:0006471,GO:0006476,GO:0007005,GO:0007568,GO:0008270,GO:0009060,GO:0017136,GO:0019899,GO:0032024,GO:0034979,GO:0034983,GO:0070373,GO:0070403,GO:2000378 NAD+ ADP-ribosyltransferase activity|mitochondrion|mitochondrial matrix|protein ADP-ribosylation|protein deacetylation|mitochondrion organization|aging|zinc ion binding|aerobic respiration|NAD-dependent histone deacetylase activity|enzyme binding|positive regulation of insulin secretion|NAD-dependent protein deacetylase activity|peptidyl-lysine deacetylation|negative regulation of ERK1 and ERK2 cascade|NAD+ binding|negative regulation of reactive oxygen species metabolic process hsa05230 Central carbon metabolism in cancer SIRT4 12.4178497904607 11.7519049918688 13.0837945890526 1.11333393165665 0.15488637730558 0.905538581038496 1 0.0968225 0.107334 0.121477 0.141439 GeneID:23409,Genbank:XM_006719308.3,HGNC:HGNC:14932,MIM:604482 sirtuin 4 GO:0000820,GO:0003950,GO:0005739,GO:0005743,GO:0005759,GO:0006342,GO:0006471,GO:0006541,GO:0006974,GO:0007005,GO:0010667,GO:0034983,GO:0046322,GO:0046676,GO:0046872,GO:0046889,GO:0047708,GO:0061690,GO:0070403,GO:0071456,GO:0072350,GO:1903217,GO:1904182 regulation of glutamine family amino acid metabolic process|NAD+ ADP-ribosyltransferase activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|chromatin silencing|protein ADP-ribosylation|glutamine metabolic process|cellular response to DNA damage stimulus|mitochondrion organization|negative regulation of cardiac muscle cell apoptotic process|peptidyl-lysine deacetylation|negative regulation of fatty acid oxidation|negative regulation of insulin secretion|metal ion binding|positive regulation of lipid biosynthetic process|biotinidase activity|lipoamidase activity|NAD+ binding|cellular response to hypoxia|tricarboxylic acid metabolic process|negative regulation of protein processing involved in protein targeting to mitochondrion|regulation of pyruvate dehydrogenase activity SIRT5 304.338778955093 266.997585168227 341.67997274196 1.27971184655726 0.355818994332288 0.0753089531499518 0.94157495521624 1.00789 1.10137 1.54592 1.15595 GeneID:23408,Genbank:XM_017010622.2,HGNC:HGNC:14933,MIM:604483 sirtuin 5 GO:0003950,GO:0005634,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0005829,GO:0006342,GO:0006471,GO:0006476,GO:0007005,GO:0008270,GO:0010566,GO:0010667,GO:0031667,GO:0034979,GO:0036046,GO:0036047,GO:0036048,GO:0036049,GO:0036054,GO:0036055,GO:0061697,GO:0061698,GO:0070403,GO:2000378 NAD+ ADP-ribosyltransferase activity|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|cytosol|chromatin silencing|protein ADP-ribosylation|protein deacetylation|mitochondrion organization|zinc ion binding|regulation of ketone biosynthetic process|negative regulation of cardiac muscle cell apoptotic process|response to nutrient levels|NAD-dependent protein deacetylase activity|protein demalonylation|peptidyl-lysine demalonylation|protein desuccinylation|peptidyl-lysine desuccinylation|protein-malonyllysine demalonylase activity|protein-succinyllysine desuccinylase activity|protein-glutaryllysine deglutarylase activity|protein deglutarylation|NAD+ binding|negative regulation of reactive oxygen species metabolic process SIRT6 424.765236456412 445.861804225846 403.668668686977 0.90536723455796 -0.143424998811991 0.53844877584974 1 5.89485 7.0554 5.45827 6.24865 GeneID:51548,Genbank:NM_001321062.1,HGNC:HGNC:14934,MIM:606211 sirtuin 6 GO:0003247,GO:0003682,GO:0003714,GO:0003950,GO:0003956,GO:0005634,GO:0005654,GO:0005724,GO:0005737,GO:0006284,GO:0006471,GO:0008270,GO:0008285,GO:0010569,GO:0017136,GO:0031648,GO:0031667,GO:0031940,GO:0032206,GO:0034979,GO:0042593,GO:0045820,GO:0045892,GO:0046325,GO:0046969,GO:0048146,GO:0070403,GO:1902732,GO:1905549,GO:1905555,GO:1905564,GO:2000648 post-embryonic cardiac muscle cell growth involved in heart morphogenesis|chromatin binding|transcription corepressor activity|NAD+ ADP-ribosyltransferase activity|NAD(P)+-protein-arginine ADP-ribosyltransferase activity|nucleus|nucleoplasm|nuclear telomeric heterochromatin|cytoplasm|base-excision repair|protein ADP-ribosylation|zinc ion binding|negative regulation of cell proliferation|regulation of double-strand break repair via homologous recombination|NAD-dependent histone deacetylase activity|protein destabilization|response to nutrient levels|positive regulation of chromatin silencing at telomere|positive regulation of telomere maintenance|NAD-dependent protein deacetylase activity|glucose homeostasis|negative regulation of glycolytic process|negative regulation of transcription, DNA-templated|negative regulation of glucose import|NAD-dependent histone deacetylase activity (H3-K9 specific)|positive regulation of fibroblast proliferation|NAD+ binding|positive regulation of chondrocyte proliferation|positive regulation of telomeric heterochromatin assembly|positive regulation blood vessel branching|positive regulation of vascular endothelial cell proliferation|positive regulation of stem cell proliferation hsa04714,hsa05230 Thermogenesis|Central carbon metabolism in cancer SIRT7 786.814682953757 781.813344244297 791.816021663218 1.01279420144535 0.0183410500349046 0.927679589971731 1 6.25497 6.84166 6.29519 7.29963 GeneID:51547,Genbank:NM_016538.2,HGNC:HGNC:14935,MIM:606212 sirtuin 7 GO:0000122,GO:0003682,GO:0005730,GO:0005731,GO:0005737,GO:0007072,GO:0009303,GO:0046872,GO:0070403,GO:0070932,GO:0097372 negative regulation of transcription from RNA polymerase II promoter|chromatin binding|nucleolus|nucleolus organizer region|cytoplasm|positive regulation of transcription involved in exit from mitosis|rRNA transcription|metal ion binding|NAD+ binding|histone H3 deacetylation|NAD-dependent histone deacetylase activity (H3-K18 specific) SIVA1 681.291739431068 689.037995796902 673.545483065235 0.977515735233513 -0.032808168978223 0.881519251731387 1 17.5979 17.2965 15.5059 19.9956 GeneID:10572,Genbank:XM_011536360.2,HGNC:HGNC:17712,MIM:605567 SIVA1 apoptosis inducing factor GO:0001618,GO:0005164,GO:0005175,GO:0005654,GO:0005737,GO:0005739,GO:0006924,GO:0008270,GO:0032088,GO:0046872,GO:0097191,GO:0097193,GO:1901030 virus receptor activity|tumor necrosis factor receptor binding|CD27 receptor binding|nucleoplasm|cytoplasm|mitochondrion|activation-induced cell death of T cells|zinc ion binding|negative regulation of NF-kappaB transcription factor activity|metal ion binding|extrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway hsa04115 p53 signaling pathway SIX1 67.9756186120249 67.1289564121959 68.8222808118539 1.02522494747662 0.0359404902217383 0.945126796395833 1 1.04536 1.05837 1.21407 0.957666 GeneID:6495,Genbank:XM_017021602.2,HGNC:HGNC:10887,MIM:601205 SIX homeobox 1 hsa05202 Transcriptional misregulation in cancer SIX2 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0241493 0.0260087 0 GeneID:10736,Genbank:XM_005264100.3,HGNC:HGNC:10888,MIM:604994 SIX homeobox 2 GO:0000978,GO:0001077,GO:0001822,GO:0002062,GO:0003337,GO:0003700,GO:0005634,GO:0006606,GO:0007501,GO:0008134,GO:0008283,GO:0009653,GO:0009948,GO:0016477,GO:0030278,GO:0032330,GO:0032403,GO:0042474,GO:0045596,GO:0048557,GO:0048701,GO:0072006,GO:0072028,GO:0072038,GO:0072137,GO:0072161,GO:0090189,GO:0097168,GO:1902732 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|kidney development|chondrocyte differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|DNA binding transcription factor activity|nucleus|protein import into nucleus|mesodermal cell fate specification|transcription factor binding|cell proliferation|anatomical structure morphogenesis|anterior/posterior axis specification|cell migration|regulation of ossification|regulation of chondrocyte differentiation|protein complex binding|middle ear morphogenesis|negative regulation of cell differentiation|embryonic digestive tract morphogenesis|embryonic cranial skeleton morphogenesis|nephron development|nephron morphogenesis|mesenchymal stem cell maintenance involved in nephron morphogenesis|condensed mesenchymal cell proliferation|mesenchymal cell differentiation involved in kidney development|regulation of branching involved in ureteric bud morphogenesis|mesenchymal stem cell proliferation|positive regulation of chondrocyte proliferation SIX3 1.696434100975 0 3.39286820195 Inf Inf 0.190672534648743 1 0 0 0.0791864 0.0556263 GeneID:6496,Genbank:NM_005413.3,HGNC:HGNC:10889,MIM:603714 SIX homeobox 3 GO:0000060,GO:0000980,GO:0001205,GO:0001222,GO:0001654,GO:0002070,GO:0002088,GO:0003404,GO:0003700,GO:0003713,GO:0005102,GO:0005634,GO:0007420,GO:0007601,GO:0009946,GO:0014016,GO:0021537,GO:0021797,GO:0021798,GO:0021846,GO:0021978,GO:0021983,GO:0030178,GO:0042127,GO:0042826,GO:0045665,GO:0045892,GO:0048512,GO:0060235,GO:0061074,GO:0070306,GO:0097402,GO:1901987,GO:1902692,GO:1902742,GO:1990086,GO:2000177 protein import into nucleus, translocation|RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|transcription corepressor binding|eye development|epithelial cell maturation|lens development in camera-type eye|optic vesicle morphogenesis|DNA binding transcription factor activity|transcription coactivator activity|receptor binding|nucleus|brain development|visual perception|proximal/distal axis specification|neuroblast differentiation|telencephalon development|forebrain anterior/posterior pattern specification|forebrain dorsal/ventral pattern formation|cell proliferation in forebrain|telencephalon regionalization|pituitary gland development|negative regulation of Wnt signaling pathway|regulation of cell proliferation|histone deacetylase binding|negative regulation of neuron differentiation|negative regulation of transcription, DNA-templated|circadian behavior|lens induction in camera-type eye|regulation of neural retina development|lens fiber cell differentiation|neuroblast migration|regulation of cell cycle phase transition|regulation of neuroblast proliferation|apoptotic process involved in development|lens fiber cell apoptotic process|regulation of neural precursor cell proliferation SIX4 151.521539253605 165.871405577341 137.171672929868 0.826976008628016 -0.274082618858947 0.31340288523824 1 1.18512 1.03101 1.1573 0.688737 GeneID:51804,Genbank:NM_017420.4,HGNC:HGNC:10890,MIM:606342 SIX homeobox 4 GO:0000978,GO:0001077,GO:0005634,GO:0005737,GO:0007519,GO:0008582,GO:0008584,GO:0009653,GO:0030238,GO:0030910,GO:0032880,GO:0034504,GO:0042472,GO:0043066,GO:0043524,GO:0043586,GO:0045214,GO:0045892,GO:0045893,GO:0046661,GO:0048538,GO:0048699,GO:0048701,GO:0050678,GO:0051451,GO:0060037,GO:0061055,GO:0061197,GO:0061551,GO:0072075,GO:0072095,GO:0072107,GO:0090190,GO:0098528,GO:1902725 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|cytoplasm|skeletal muscle tissue development|regulation of synaptic growth at neuromuscular junction|male gonad development|anatomical structure morphogenesis|male sex determination|olfactory placode formation|regulation of protein localization|protein localization to nucleus|inner ear morphogenesis|negative regulation of apoptotic process|negative regulation of neuron apoptotic process|tongue development|sarcomere organization|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|male sex differentiation|thymus development|generation of neurons|embryonic cranial skeleton morphogenesis|regulation of epithelial cell proliferation|myoblast migration|pharyngeal system development|myotome development|fungiform papilla morphogenesis|trigeminal ganglion development|metanephric mesenchyme development|regulation of branch elongation involved in ureteric bud branching|positive regulation of ureteric bud formation|positive regulation of branching involved in ureteric bud morphogenesis|skeletal muscle fiber differentiation|negative regulation of satellite cell differentiation hsa05202 Transcriptional misregulation in cancer SIX5 370.269331846591 371.275915579812 369.262748113371 0.994577705199925 -0.00784400333849333 0.947061720388959 1 4.81232 5.63414 5.04831 5.42809 GeneID:147912,Genbank:NM_175875.4,HGNC:HGNC:10891,MIM:600963 SIX homeobox 5 GO:0000978,GO:0002088,GO:0005634,GO:0005737,GO:0006351,GO:0007286,GO:0045892,GO:0045944,GO:1902723 RNA polymerase II proximal promoter sequence-specific DNA binding|lens development in camera-type eye|nucleus|cytoplasm|transcription, DNA-templated|spermatid development|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of skeletal muscle satellite cell proliferation SKA1 391.806497151502 416.764278065875 366.848716237129 0.880230709646241 -0.184046389274562 0.324975158825949 1 5.68403 5.8695 5.02047 5.08282 GeneID:220134,Genbank:NM_001039535.2,HGNC:HGNC:28109,MIM:616673 spindle and kinetochore associated complex subunit 1 GO:0000278,GO:0000940,GO:0005829,GO:0005876,GO:0007059,GO:0007062,GO:0008017,GO:0015630,GO:0031110,GO:0051301 mitotic cell cycle|condensed chromosome outer kinetochore|cytosol|spindle microtubule|chromosome segregation|sister chromatid cohesion|microtubule binding|microtubule cytoskeleton|regulation of microtubule polymerization or depolymerization|cell division SKA2 2679.869623113 2469.79639696535 2889.94284926066 1.17011380080218 0.226648847645386 0.0938175017966632 0.992100325879928 28.3148 28.6185 36.7214 30.9734 GeneID:348235,Genbank:NM_001330399.1,HGNC:HGNC:28006,MIM:616674 spindle and kinetochore associated complex subunit 2 GO:0000278,GO:0000940,GO:0005737,GO:0005876,GO:0007059,GO:0008017,GO:0031110,GO:0051301 mitotic cell cycle|condensed chromosome outer kinetochore|cytoplasm|spindle microtubule|chromosome segregation|microtubule binding|regulation of microtubule polymerization or depolymerization|cell division SKA3 677.569167623613 736.245495516515 618.89283973071 0.84060662306195 -0.250497271491706 0.133761471652994 1 9.10175 8.32483 8.00976 6.88102 GeneID:221150,Genbank:NM_001166017.1,HGNC:HGNC:20262 spindle and kinetochore associated complex subunit 3 GO:0000278,GO:0000776,GO:0000940,GO:0005737,GO:0005876,GO:0007059,GO:0031110,GO:0051301 mitotic cell cycle|kinetochore|condensed chromosome outer kinetochore|cytoplasm|spindle microtubule|chromosome segregation|regulation of microtubule polymerization or depolymerization|cell division SKAP1 3.48415840587988 3.57457863775636 3.3937381740034 0.949409292093103 -0.0748979250536205 1 1 0.0272977 0.0385106 0.026117 0.0121333 GeneID:8631,Genbank:XM_017025259.1,HGNC:HGNC:15605,MIM:604969 src kinase associated phosphoprotein 1 GO:0002250,GO:0005070,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005911,GO:0017124,GO:0019901,GO:0019903,GO:0032403,GO:0042101,GO:0042169,GO:0045785,GO:0045893,GO:0045944,GO:0050852,GO:0072659 adaptive immune response|SH3/SH2 adaptor activity|nucleus|cytoplasm|cytosol|plasma membrane|cell-cell junction|SH3 domain binding|protein kinase binding|protein phosphatase binding|protein complex binding|T cell receptor complex|SH2 domain binding|positive regulation of cell adhesion|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|protein localization to plasma membrane hsa04015 Rap1 signaling pathway SKAP2 886.81772850732 898.311999737783 875.323457276857 0.974409178027638 -0.0374003727344563 0.846855202945719 1 4.99911 4.60056 5.33977 4.21217 GeneID:8935,Genbank:XM_017012771.2,HGNC:HGNC:15687,MIM:605215 src kinase associated phosphoprotein 2 GO:0002757,GO:0005070,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006461,GO:0007165,GO:0008285,GO:0042113 immune response-activating signal transduction|SH3/SH2 adaptor activity|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein complex assembly|signal transduction|negative regulation of cell proliferation|B cell activation SKI 1934.83366540851 1865.69769218879 2003.96963862822 1.07411272845453 0.103145412548495 0.479350107019873 1 8.55528 9.02055 9.94815 9.27642 GeneID:6497,Genbank:NM_003036.3,HGNC:HGNC:10896,MIM:164780 SKI proto-oncogene GO:0000122,GO:0001843,GO:0002089,GO:0003714,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005813,GO:0006351,GO:0007179,GO:0008270,GO:0008283,GO:0008285,GO:0009948,GO:0010626,GO:0014902,GO:0016604,GO:0016605,GO:0017053,GO:0019901,GO:0019904,GO:0021772,GO:0022011,GO:0030177,GO:0030326,GO:0030509,GO:0030512,GO:0030514,GO:0031625,GO:0032926,GO:0035019,GO:0043010,GO:0043234,GO:0043388,GO:0043585,GO:0045668,GO:0045944,GO:0046332,GO:0046811,GO:0048147,GO:0048593,GO:0048666,GO:0048741,GO:0048870,GO:0060021,GO:0060041,GO:0060325,GO:0060349,GO:0060395,GO:0070207,GO:0070491 negative regulation of transcription from RNA polymerase II promoter|neural tube closure|lens morphogenesis in camera-type eye|transcription corepressor activity|nucleus|nucleoplasm|transcription factor complex|cytoplasm|centrosome|transcription, DNA-templated|transforming growth factor beta receptor signaling pathway|zinc ion binding|cell proliferation|negative regulation of cell proliferation|anterior/posterior axis specification|negative regulation of Schwann cell proliferation|myotube differentiation|nuclear body|PML body|transcriptional repressor complex|protein kinase binding|protein domain specific binding|olfactory bulb development|myelination in peripheral nervous system|positive regulation of Wnt signaling pathway|embryonic limb morphogenesis|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|ubiquitin protein ligase binding|negative regulation of activin receptor signaling pathway|somatic stem cell population maintenance|camera-type eye development|protein complex|positive regulation of DNA binding|nose morphogenesis|negative regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|SMAD binding|histone deacetylase inhibitor activity|negative regulation of fibroblast proliferation|camera-type eye morphogenesis|neuron development|skeletal muscle fiber development|cell motility|palate development|retina development in camera-type eye|face morphogenesis|bone morphogenesis|SMAD protein signal transduction|protein homotrimerization|repressing transcription factor binding SKIDA1 233.938072490258 209.074124188743 258.802020791772 1.23784816411876 0.307834362769474 0.157528353580701 1 0.939212 1.00375 1.31668 1.11918 GeneID:387640,Genbank:XM_011519480.3,HGNC:HGNC:32697 SKI/DACH domain containing 1 SKIL 389.966568360251 437.240398742752 342.692737977751 0.783762751482102 -0.351511084755345 0.249204390386994 1 2.59459 2.18551 2.23179 1.38685 GeneID:6498,Genbank:XM_006713735.1,HGNC:HGNC:10897,MIM:165340 SKI like proto-oncogene GO:0000122,GO:0000978,GO:0001078,GO:0001669,GO:0001825,GO:0002260,GO:0003682,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0007050,GO:0007179,GO:0007283,GO:0007519,GO:0016605,GO:0019904,GO:0030512,GO:0030514,GO:0032403,GO:0034097,GO:0043234,GO:0045596,GO:0046332,GO:0046677,GO:0048666,GO:0050772,GO:0070207,GO:0070208,GO:0070306,GO:0070848,GO:1902043,GO:1902231 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|acrosomal vesicle|blastocyst formation|lymphocyte homeostasis|chromatin binding|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|cell cycle arrest|transforming growth factor beta receptor signaling pathway|spermatogenesis|skeletal muscle tissue development|PML body|protein domain specific binding|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|protein complex binding|response to cytokine|protein complex|negative regulation of cell differentiation|SMAD binding|response to antibiotic|neuron development|positive regulation of axonogenesis|protein homotrimerization|protein heterotrimerization|lens fiber cell differentiation|response to growth factor|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage hsa04550 Signaling pathways regulating pluripotency of stem cells SKIV2L 2122.23851762083 2075.41577525866 2169.06125998301 1.04512131296327 0.0636704135525518 0.666728301842825 1 16.5074 17.3021 17.4977 19.2782 GeneID:6499,Genbank:NM_006929.4,HGNC:HGNC:10898,MIM:600478 Ski2 like RNA helicase GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005829,GO:0043928,GO:0055087,GO:0070478 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|cytosol|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|Ski complex|nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay hsa03018 RNA degradation SKOR1 9.17959705761289 8.66739775606975 9.69179635915603 1.11818986873758 0.161165178725614 0.934258908925228 1 0.0843483 0.108373 0.103293 0.096581 GeneID:390598,Genbank:NM_001258024.1,HGNC:HGNC:21326,MIM:611273 SKI family transcriptional corepressor 1 GO:0003714,GO:0005634,GO:0005667,GO:0006351,GO:0006355,GO:0030425,GO:0030512,GO:0030514,GO:0043025,GO:0045596,GO:0045892,GO:0046332,GO:0048666 transcription corepressor activity|nucleus|transcription factor complex|transcription, DNA-templated|regulation of transcription, DNA-templated|dendrite|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|neuronal cell body|negative regulation of cell differentiation|negative regulation of transcription, DNA-templated|SMAD binding|neuron development SKP1 4968.31794374744 5627.72708216283 4308.90880533205 0.765657030346977 -0.385229801199198 0.0179005065556851 0.546850871863472 72.4034 71.2444 50.8395 59.4713 GeneID:6500,Genbank:NM_170679.2,HGNC:HGNC:10899,MIM:601434 S-phase kinase associated protein 1 GO:0000086,GO:0000209,GO:0002223,GO:0004842,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006879,GO:0008013,GO:0010265,GO:0010972,GO:0016055,GO:0016567,GO:0019005,GO:0019904,GO:0031146,GO:0031467,GO:0035518,GO:0038061,GO:0038095,GO:0043161,GO:0043687,GO:0050852,GO:0051403,GO:0051437,GO:0051457,GO:0070062,GO:0070498,GO:0097602 G2/M transition of mitotic cell cycle|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytoplasm|cytosol|cellular iron ion homeostasis|beta-catenin binding|SCF complex assembly|negative regulation of G2/M transition of mitotic cell cycle|Wnt signaling pathway|protein ubiquitination|SCF ubiquitin ligase complex|protein domain specific binding|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|Cul7-RING ubiquitin ligase complex|histone H2A monoubiquitination|NIK/NF-kappaB signaling|Fc-epsilon receptor signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|post-translational protein modification|T cell receptor signaling pathway|stress-activated MAPK cascade|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|maintenance of protein location in nucleus|extracellular exosome|interleukin-1-mediated signaling pathway|cullin family protein binding hsa04110,hsa04114,hsa04120,hsa04141,hsa04310,hsa04350,hsa04710,hsa05168,hsa05170,hsa05200 Cell cycle|Oocyte meiosis|Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Wnt signaling pathway|TGF-beta signaling pathway|Circadian rhythm|Herpes simplex infection|Human immunodeficiency virus 1 infection|Pathways in cancer SKP2 380.209023886221 422.164872142514 338.253175629928 0.80123477330852 -0.31970305991857 0.085487388403051 0.964561165794104 2.58551 3.04664 2.1495 2.32387 GeneID:6502,Genbank:NM_005983.3,HGNC:HGNC:10901,MIM:601436 S-phase kinase associated protein 2 GO:0000082,GO:0000086,GO:0000209,GO:0004842,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0008283,GO:0016579,GO:0019005,GO:0031145,GO:0033148,GO:0042802,GO:0042981,GO:0043687,GO:0048661,GO:0051726,GO:0061630,GO:0071460,GO:1902916 G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|nucleoplasm|nucleolus|cytosol|cell proliferation|protein deubiquitination|SCF ubiquitin ligase complex|anaphase-promoting complex-dependent catabolic process|positive regulation of intracellular estrogen receptor signaling pathway|identical protein binding|regulation of apoptotic process|post-translational protein modification|positive regulation of smooth muscle cell proliferation|regulation of cell cycle|ubiquitin protein ligase activity|cellular response to cell-matrix adhesion|positive regulation of protein polyubiquitination hsa04068,hsa04110,hsa04120,hsa04150,hsa05168,hsa05169,hsa05200,hsa05203,hsa05222 FoxO signaling pathway|Cell cycle|Ubiquitin mediated proteolysis|mTOR signaling pathway|Herpes simplex infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer SLA 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0202775 0 0 GeneID:6503,Genbank:NM_001282965.1,HGNC:HGNC:10902,MIM:601099 Src like adaptor GO:0004715,GO:0005070,GO:0005102,GO:0005768,GO:0007169,GO:0016477,GO:0030154,GO:0031234,GO:0038083,GO:0042127,GO:0045087 non-membrane spanning protein tyrosine kinase activity|SH3/SH2 adaptor activity|receptor binding|endosome|transmembrane receptor protein tyrosine kinase signaling pathway|cell migration|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|innate immune response SLA2 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0 0 0 0 GeneID:84174,Genbank:NM_175077.2,HGNC:HGNC:17329,MIM:606577 Src like adaptor 2 GO:0000122,GO:0004715,GO:0005070,GO:0005102,GO:0005654,GO:0005737,GO:0005770,GO:0005794,GO:0005886,GO:0007169,GO:0010008,GO:0016477,GO:0019724,GO:0030154,GO:0030522,GO:0031234,GO:0038083,GO:0042110,GO:0042127,GO:0043231,GO:0045087,GO:0047485,GO:0050776,GO:0050849,GO:0050851,GO:0050869 negative regulation of transcription from RNA polymerase II promoter|non-membrane spanning protein tyrosine kinase activity|SH3/SH2 adaptor activity|receptor binding|nucleoplasm|cytoplasm|late endosome|Golgi apparatus|plasma membrane|transmembrane receptor protein tyrosine kinase signaling pathway|endosome membrane|cell migration|B cell mediated immunity|cell differentiation|intracellular receptor signaling pathway|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|T cell activation|regulation of cell proliferation|intracellular membrane-bounded organelle|innate immune response|protein N-terminus binding|regulation of immune response|negative regulation of calcium-mediated signaling|antigen receptor-mediated signaling pathway|negative regulation of B cell activation SLAIN1 877.71827837552 818.614691664074 936.821865086967 1.14439903733294 0.194590189180951 0.204206484203837 1 8.29707 7.63837 10.0453 8.75825 GeneID:122060,Genbank:NM_001242868.1,HGNC:HGNC:26387,MIM:610491 SLAIN motif family member 1 GO:0005737,GO:0005856 cytoplasm|cytoskeleton SLAIN2 1355.09280383518 1280.79968863111 1429.38591903925 1.11601051415537 0.158350619145915 0.548833284032824 1 9.59762 8.34643 12.0906 8.2166 GeneID:57606,Genbank:XM_005248121.3,HGNC:HGNC:29282,MIM:610492 SLAIN motif family member 2 GO:0005813,GO:0005829,GO:0007020,GO:0015630,GO:0031116,GO:0031122 centrosome|cytosol|microtubule nucleation|microtubule cytoskeleton|positive regulation of microtubule polymerization|cytoplasmic microtubule organization SLAMF7 1.94103481592698 0.490071401957362 3.3919982298966 6.92143678726986 2.79107155097012 0.35751656982365 1 0 0.0102491 0.031296 0.038916 GeneID:57823,Genbank:NM_021181.4,HGNC:HGNC:21394,MIM:606625 SLAM family member 7 GO:0002250,GO:0005886,GO:0007155,GO:0016021,GO:0030101,GO:0042267,GO:0042802,GO:0050776 adaptive immune response|plasma membrane|cell adhesion|integral component of membrane|natural killer cell activation|natural killer cell mediated cytotoxicity|identical protein binding|regulation of immune response SLAMF8 1.02566752891457 1.56626675524197 0.48506830258717 0.309697119576692 -1.69107012999473 0.789536483244536 1 0.017202 0.00786551 0.00812133 0 GeneID:56833,Genbank:XM_011509775.2,HGNC:HGNC:21391,MIM:606620 SLAM family member 8 GO:0016021 integral component of membrane SLAMF9 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0128245 0 GeneID:89886,Genbank:XM_017002756.1,HGNC:HGNC:18430,MIM:608589 SLAM family member 9 GO:0016021 integral component of membrane SLBP 2664.23664986185 2775.95268501633 2552.52061470736 0.919511571103145 -0.121060365309324 0.381588393677929 1 53.573 53.0902 50.3303 48.6488 GeneID:7884,Genbank:NM_001306075.1,HGNC:HGNC:10904,MIM:602422 stem-loop binding protein GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006369,GO:0006398,GO:0006406,GO:0008334,GO:0030529,GO:0033260,GO:0044770,GO:0051028,GO:0071204,GO:0071207,GO:0071208 RNA binding|mRNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|termination of RNA polymerase II transcription|mRNA 3'-end processing by stem-loop binding and cleavage|mRNA export from nucleus|histone mRNA metabolic process|intracellular ribonucleoprotein complex|nuclear DNA replication|cell cycle phase transition|mRNA transport|histone pre-mRNA 3'end processing complex|histone pre-mRNA stem-loop binding|histone pre-mRNA DCP binding SLC10A3 1083.56995230515 1076.72538201388 1090.41452259642 1.01271367872553 0.0182263432694915 0.921725225899294 1 13.7473 14.1444 14.6284 14.2496 GeneID:8273,Genbank:NM_001142391.2,HGNC:HGNC:22979,MIM:312090 solute carrier family 10 member 3 GO:0008508,GO:0016021,GO:0032526 bile acid:sodium symporter activity|integral component of membrane|response to retinoic acid SLC10A4 1.24125200715389 1.02816907859967 1.45433493570811 1.4144900541931 0.500282032643154 1 1 0.0301835 0 0.0566894 0.0264019 GeneID:201780,Genbank:NM_152679.3,HGNC:HGNC:22980 solute carrier family 10 member 4 GO:0005886,GO:0008508,GO:0015721,GO:0016021 plasma membrane|bile acid:sodium symporter activity|bile acid and bile salt transport|integral component of membrane SLC10A5 1.24125200715389 1.02816907859967 1.45433493570811 1.4144900541931 0.500282032643154 1 1 0.039042 0.0381568 0.0378539 0.0351433 GeneID:347051,Genbank:NM_001010893.2,HGNC:HGNC:22981 solute carrier family 10 member 5 GO:0008508,GO:0016021 bile acid:sodium symporter activity|integral component of membrane SLC10A6 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0 0.0298057 0.0307734 0 GeneID:345274,Genbank:NM_197965.2,HGNC:HGNC:30603,MIM:613366 solute carrier family 10 member 6 GO:0005886,GO:0008508,GO:0016021,GO:0043250,GO:0043251,GO:0055085 plasma membrane|bile acid:sodium symporter activity|integral component of membrane|sodium-dependent organic anion transmembrane transporter activity|sodium-dependent organic anion transport|transmembrane transport SLC10A7 51.980145281621 48.2278941448144 55.7323964184275 1.15560501669592 0.208648372035779 0.615234308701976 1 0.13656 0.160086 0.173552 0.168137 GeneID:84068,Genbank:XM_011532311.2,HGNC:HGNC:23088,MIM:611459 solute carrier family 10 member 7 GO:0006814,GO:0015293,GO:0016021 sodium ion transport|symporter activity|integral component of membrane SLC11A1 6.20038696434586 4.16070258908361 8.24007133960811 1.98045189801057 0.985829660927274 0.429601401389616 1 0.0236046 0.0206236 0.109658 0.0716596 GeneID:6556,Genbank:XM_011511684.3,HGNC:HGNC:10907,MIM:600266 solute carrier family 11 member 1 GO:0001818,GO:0001819,GO:0002309,GO:0002369,GO:0002606,GO:0002827,GO:0005384,GO:0005764,GO:0005770,GO:0005886,GO:0005887,GO:0006826,GO:0006828,GO:0006876,GO:0006879,GO:0006909,GO:0006954,GO:0007035,GO:0009617,GO:0010628,GO:0015707,GO:0019730,GO:0030670,GO:0031902,GO:0032147,GO:0032496,GO:0032623,GO:0032632,GO:0032729,GO:0034341,GO:0042060,GO:0042116,GO:0042742,GO:0042803,GO:0042832,GO:0043091,GO:0043312,GO:0045342,GO:0045454,GO:0045730,GO:0045944,GO:0046915,GO:0048002,GO:0048255,GO:0050766,GO:0050829,GO:0051139,GO:0055072,GO:0060586,GO:0070574,GO:0070821,GO:0070839,GO:0101003 negative regulation of cytokine production|positive regulation of cytokine production|T cell proliferation involved in immune response|T cell cytokine production|positive regulation of dendritic cell antigen processing and presentation|positive regulation of T-helper 1 type immune response|manganese ion transmembrane transporter activity|lysosome|late endosome|plasma membrane|integral component of plasma membrane|iron ion transport|manganese ion transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|phagocytosis|inflammatory response|vacuolar acidification|response to bacterium|positive regulation of gene expression|nitrite transport|antimicrobial humoral response|phagocytic vesicle membrane|late endosome membrane|activation of protein kinase activity|response to lipopolysaccharide|interleukin-2 production|interleukin-3 production|positive regulation of interferon-gamma production|response to interferon-gamma|wound healing|macrophage activation|defense response to bacterium|protein homodimerization activity|defense response to protozoan|L-arginine import|neutrophil degranulation|MHC class II biosynthetic process|cell redox homeostasis|respiratory burst|positive regulation of transcription from RNA polymerase II promoter|transition metal ion transmembrane transporter activity|antigen processing and presentation of peptide antigen|mRNA stabilization|positive regulation of phagocytosis|defense response to Gram-negative bacterium|metal ion:proton antiporter activity|iron ion homeostasis|multicellular organismal iron ion homeostasis|cadmium ion transmembrane transport|tertiary granule membrane|divalent metal ion export|ficolin-1-rich granule membrane hsa04142 Lysosome SLC11A2 1405.56539038317 1405.70025254534 1405.43052822099 0.999808121024481 -0.000276849408071972 1 1 7.08389 7.02654 7.29096 6.92727 GeneID:4891,Genbank:NM_001174127.1,HGNC:HGNC:10908,MIM:600523 solute carrier family 11 member 2 GO:0001666,GO:0003032,GO:0005375,GO:0005381,GO:0005384,GO:0005385,GO:0005634,GO:0005737,GO:0005739,GO:0005741,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005773,GO:0005802,GO:0005886,GO:0005887,GO:0006783,GO:0006824,GO:0006825,GO:0006828,GO:0006879,GO:0006919,GO:0007611,GO:0009986,GO:0010039,GO:0015086,GO:0015087,GO:0015093,GO:0015094,GO:0015099,GO:0015100,GO:0015295,GO:0015675,GO:0015676,GO:0015684,GO:0015692,GO:0016020,GO:0016324,GO:0022890,GO:0031410,GO:0031526,GO:0031902,GO:0034599,GO:0045177,GO:0045178,GO:0046870,GO:0046915,GO:0048471,GO:0048813,GO:0048821,GO:0055037,GO:0060586,GO:0070574,GO:0070627,GO:0070826,GO:1903561 response to hypoxia|detection of oxygen|copper ion transmembrane transporter activity|iron ion transmembrane transporter activity|manganese ion transmembrane transporter activity|zinc ion transmembrane transporter activity|nucleus|cytoplasm|mitochondrion|mitochondrial outer membrane|lysosome|lysosomal membrane|early endosome|late endosome|vacuole|trans-Golgi network|plasma membrane|integral component of plasma membrane|heme biosynthetic process|cobalt ion transport|copper ion transport|manganese ion transport|cellular iron ion homeostasis|activation of cysteine-type endopeptidase activity involved in apoptotic process|learning or memory|cell surface|response to iron ion|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|nickel cation transmembrane transporter activity|vanadium ion transmembrane transporter activity|solute:proton symporter activity|nickel cation transport|vanadium ion transport|ferrous iron transport|lead ion transport|membrane|apical plasma membrane|inorganic cation transmembrane transporter activity|cytoplasmic vesicle|brush border membrane|late endosome membrane|cellular response to oxidative stress|apical part of cell|basal part of cell|cadmium ion binding|transition metal ion transmembrane transporter activity|perinuclear region of cytoplasm|dendrite morphogenesis|erythrocyte development|recycling endosome|multicellular organismal iron ion homeostasis|cadmium ion transmembrane transport|ferrous iron import|paraferritin complex|extracellular vesicle hsa04142,hsa04216,hsa04978 Lysosome|Ferroptosis|Mineral absorption SLC12A1 1.0016543915721 1.51824048055703 0.48506830258717 0.319493722370782 -1.64614051048666 0.791481013618379 1 0.00822325 0.0157309 0.00792823 0 GeneID:6557,Genbank:NM_000338.2,HGNC:HGNC:10910,MIM:600839 solute carrier family 12 member 1 GO:0005886,GO:0006810,GO:0006811,GO:0006813,GO:0006814,GO:0008511,GO:0016020,GO:0016021,GO:0016324,GO:0034220,GO:0070062 plasma membrane|transport|ion transport|potassium ion transport|sodium ion transport|sodium:potassium:chloride symporter activity|membrane|integral component of membrane|apical plasma membrane|ion transmembrane transport|extracellular exosome SLC12A2 446.921163467334 472.621592233052 421.220734701615 0.89124310362424 -0.166109086759283 0.552789845850181 1 1.81625 1.70921 2.01277 1.25538 GeneID:6558,Genbank:NM_001046.2,HGNC:HGNC:10911,MIM:600840 solute carrier family 12 member 2 GO:0005524,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006813,GO:0006814,GO:0006972,GO:0007214,GO:0007568,GO:0008511,GO:0008519,GO:0015696,GO:0016020,GO:0016324,GO:0019901,GO:0030321,GO:0042626,GO:0045795,GO:0070062,GO:0070634,GO:1903561 ATP binding|plasma membrane|integral component of plasma membrane|transport|ion transport|potassium ion transport|sodium ion transport|hyperosmotic response|gamma-aminobutyric acid signaling pathway|aging|sodium:potassium:chloride symporter activity|ammonium transmembrane transporter activity|ammonium transport|membrane|apical plasma membrane|protein kinase binding|transepithelial chloride transport|ATPase activity, coupled to transmembrane movement of substances|positive regulation of cell volume|extracellular exosome|transepithelial ammonium transport|extracellular vesicle hsa04970,hsa04972,hsa05110 Salivary secretion|Pancreatic secretion|Vibrio cholerae infection SLC12A3 1.51236740913344 2.05633815719933 0.968396661067546 0.470932593298016 -1.08640751970762 0.811664485952849 1 0.0147605 0.0132767 0 0.0129691 GeneID:6559,Genbank:NM_000339.2,HGNC:HGNC:10912,MIM:600968 solute carrier family 12 member 3 GO:0005215,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006814,GO:0015378,GO:0016020,GO:0016324,GO:0035725,GO:0070062 transporter activity|cytosol|plasma membrane|integral component of plasma membrane|transport|ion transport|sodium ion transport|sodium:chloride symporter activity|membrane|apical plasma membrane|sodium ion transmembrane transport|extracellular exosome SLC12A4 1561.59526627527 1482.2386521458 1640.95188040474 1.10707670322129 0.146755181941865 0.325048473935256 1 9.64076 10.4528 11.8123 11.4121 GeneID:6560,Genbank:NM_001145962.1,HGNC:HGNC:10913,MIM:604119 solute carrier family 12 member 4 GO:0005765,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0007268,GO:0015379,GO:0016020,GO:0019901,GO:0022820 lysosomal membrane|plasma membrane|integral component of plasma membrane|transport|ion transport|cell volume homeostasis|chemical synaptic transmission|potassium:chloride symporter activity|membrane|protein kinase binding|potassium ion symporter activity SLC12A5 2.21008365424813 1.02816907859967 3.3919982298966 3.29906656453469 1.72205788713451 0.509810573635166 1 0 0 0.00735015 0.027418 GeneID:57468,Genbank:NM_001134771.1,HGNC:HGNC:13818,MIM:606726 solute carrier family 12 member 5 GO:0005886,GO:0005887,GO:0006811,GO:0006873,GO:0006971,GO:0007268,GO:0007612,GO:0015108,GO:0015379,GO:0016021,GO:0019901,GO:0022820,GO:0030644,GO:0035264,GO:0040040,GO:0042493,GO:0043025,GO:0043198,GO:0060996 plasma membrane|integral component of plasma membrane|ion transport|cellular ion homeostasis|hypotonic response|chemical synaptic transmission|learning|chloride transmembrane transporter activity|potassium:chloride symporter activity|integral component of membrane|protein kinase binding|potassium ion symporter activity|cellular chloride ion homeostasis|multicellular organism growth|thermosensory behavior|response to drug|neuronal cell body|dendritic shaft|dendritic spine development hsa04727 GABAergic synapse SLC12A6 391.137317981623 423.154823601537 359.11981236171 0.848672382616804 -0.236720364657282 0.195409830331735 1 1.31905 1.51163 1.42588 1.16826 GeneID:9990,Genbank:NM_001042495.1,HGNC:HGNC:10914,MIM:604878 solute carrier family 12 member 6 GO:0001525,GO:0005886,GO:0005887,GO:0006811,GO:0007268,GO:0010107,GO:0015079,GO:0015379,GO:0016021,GO:0016323,GO:0019901,GO:0022820,GO:0035826,GO:0035827,GO:0071476,GO:0071477 angiogenesis|plasma membrane|integral component of plasma membrane|ion transport|chemical synaptic transmission|potassium ion import|potassium ion transmembrane transporter activity|potassium:chloride symporter activity|integral component of membrane|basolateral plasma membrane|protein kinase binding|potassium ion symporter activity|rubidium ion transport|rubidium ion transmembrane transporter activity|cellular hypotonic response|cellular hypotonic salinity response SLC12A7 12.2189061879636 15.7205024822126 8.7173098937147 0.554518527863734 -0.850692429612075 0.397508098555247 1 0.0682359 0.124434 0.0140593 0.0985605 GeneID:10723,Genbank:NM_006598.2,HGNC:HGNC:10915,MIM:604879 solute carrier family 12 member 7 GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0007268,GO:0015379,GO:0019901,GO:0022820 plasma membrane|integral component of plasma membrane|transport|ion transport|cell volume homeostasis|chemical synaptic transmission|potassium:chloride symporter activity|protein kinase binding|potassium ion symporter activity hsa04966 Collecting duct acid secretion SLC12A8 240.022064289847 303.655870764804 176.38825781489 0.580882093175506 -0.78368273823439 0.000281472311052852 0.0450711837493147 3.53975 3.3127 1.84335 2.22856 GeneID:84561,Genbank:NM_024628.5,HGNC:HGNC:15595,MIM:611316 solute carrier family 12 member 8 GO:0015379,GO:0016021,GO:0022820 potassium:chloride symporter activity|integral component of membrane|potassium ion symporter activity SLC12A9 1054.05687576392 1070.03788717585 1038.075864352 0.970130008285768 -0.0437499973392817 0.753957053165172 1 13.1318 13.8228 13.6502 13.0272 GeneID:56996,Genbank:XM_024446840.1,HGNC:HGNC:17435,MIM:616861 solute carrier family 12 member 9 GO:0005886,GO:0015377,GO:0015379,GO:0016021,GO:0022820,GO:0070062 plasma membrane|cation:chloride symporter activity|potassium:chloride symporter activity|integral component of membrane|potassium ion symporter activity|extracellular exosome SLC13A3 1.75326998279533 1.56626675524197 1.94027321034868 1.23878847830677 0.308929870005269 1 1 0.0114475 0 0.0215782 0 GeneID:64849,Genbank:NM_001193340.1,HGNC:HGNC:14430,MIM:606411 solute carrier family 13 member 3 GO:0005886,GO:0005887,GO:0015137,GO:0015141,GO:0015362,GO:0015746,GO:0017153,GO:0070062 plasma membrane|integral component of plasma membrane|citrate transmembrane transporter activity|succinate transmembrane transporter activity|high-affinity sodium:dicarboxylate symporter activity|citrate transport|sodium:dicarboxylate symporter activity|extracellular exosome SLC13A4 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.00941021 0 0 GeneID:26266,Genbank:NM_012450.3,HGNC:HGNC:15827,MIM:604309 solute carrier family 13 member 4 GO:0005215,GO:0005886,GO:0005887,GO:0008272,GO:0015382,GO:0098656 transporter activity|plasma membrane|integral component of plasma membrane|sulfate transport|sodium:sulfate symporter activity|anion transmembrane transport SLC14A2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00671393 0 GeneID:8170,Genbank:XM_024451270.1,HGNC:HGNC:10919,MIM:601611 solute carrier family 14 member 2 GO:0005886,GO:0015204,GO:0015840,GO:0016020,GO:0016021,GO:0016324,GO:0050839,GO:0055085 plasma membrane|urea transmembrane transporter activity|urea transport|membrane|integral component of membrane|apical plasma membrane|cell adhesion molecule binding|transmembrane transport SLC15A1 1.75196502471523 1.56626675524197 1.93766329418849 1.23712214902317 0.306987953903475 1 1 0 0 0 0 GeneID:6564,Genbank:NM_005073.3,HGNC:HGNC:10920,MIM:600544 solute carrier family 15 member 1 GO:0005427,GO:0005886,GO:0005887,GO:0005903,GO:0006810,GO:0006811,GO:0007586,GO:0015031,GO:0015333,GO:0016020 proton-dependent oligopeptide secondary active transmembrane transporter activity|plasma membrane|integral component of plasma membrane|brush border|transport|ion transport|digestion|protein transport|peptide:proton symporter activity|membrane hsa04974 Protein digestion and absorption SLC15A2 10.0390113410532 10.8678147373239 9.21020794478245 0.847475611923283 -0.238756242937603 0.856661080400835 1 0.0511055 0.0629412 0.063299 0.0392557 GeneID:6565,Genbank:NM_021082.3,HGNC:HGNC:10921,MIM:602339 solute carrier family 15 member 2 GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0015031,GO:0015333,GO:0015893,GO:0035673,GO:0070062 plasma membrane|integral component of plasma membrane|transport|ion transport|protein transport|peptide:proton symporter activity|drug transport|oligopeptide transmembrane transporter activity|extracellular exosome SLC15A3 168.151051064908 108.409607035345 227.89249509447 2.10214298646216 1.07186080385956 0.358330729108807 1 1.47866 1.68165 6.55583 1.34274 GeneID:51296,Genbank:NM_016582.2,HGNC:HGNC:18068,MIM:610408 solute carrier family 15 member 3 GO:0005765,GO:0006811,GO:0015031,GO:0015333,GO:0016021,GO:0043231 lysosomal membrane|ion transport|protein transport|peptide:proton symporter activity|integral component of membrane|intracellular membrane-bounded organelle SLC15A4 492.773615684582 517.390577599696 468.156653769469 0.90484186229553 -0.144262418069498 0.410115273074274 1 5.92485 6.18671 5.58716 5.23118 GeneID:121260,Genbank:NM_145648.3,HGNC:HGNC:23090,MIM:615806 solute carrier family 15 member 4 GO:0005765,GO:0005886,GO:0006811,GO:0006857,GO:0015031,GO:0015333,GO:0016021,GO:0035579,GO:0043312 lysosomal membrane|plasma membrane|ion transport|oligopeptide transport|protein transport|peptide:proton symporter activity|integral component of membrane|specific granule membrane|neutrophil degranulation SLC16A1 3585.7188846272 3616.44403397654 3554.99373527785 0.983008088021999 -0.0247248080252451 0.883525353167827 1 34.8957 31.5917 36.3981 29.4561 GeneID:6566,Genbank:NM_003051.3,HGNC:HGNC:10922,MIM:600682 solute carrier family 16 member 1 SLC16A10 34.1628553508027 32.4593653879169 35.8663453136885 1.10496138433562 0.143995951878282 0.783687626676623 1 0.143602 0.139017 0.169413 0.114644 GeneID:117247,Genbank:XM_011535422.2,HGNC:HGNC:17027,MIM:607550 solute carrier family 16 member 10 GO:0005886,GO:0005887,GO:0006865,GO:0008028,GO:0015171,GO:0015173,GO:0015349,GO:0015801,GO:0016021,GO:0016323 plasma membrane|integral component of plasma membrane|amino acid transport|monocarboxylic acid transmembrane transporter activity|amino acid transmembrane transporter activity|aromatic amino acid transmembrane transporter activity|thyroid hormone transmembrane transporter activity|aromatic amino acid transport|integral component of membrane|basolateral plasma membrane hsa04919,hsa04974 Thyroid hormone signaling pathway|Protein digestion and absorption SLC16A12 1.5397520682144 2.59443583384164 0.48506830258717 0.186964848488436 -2.41916104230609 0.49972398725951 1 0.012243 0.0117716 0.00590849 0 GeneID:387700,Genbank:NM_213606.3,HGNC:HGNC:23094,MIM:611910 solute carrier family 16 member 12 GO:0005308,GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:1902598 creatine transmembrane transporter activity|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|creatine transmembrane transport SLC16A13 104.418116188862 99.3099728071111 109.526259570613 1.10287271735886 0.14126629896997 0.666939345164769 1 2.47037 3.23821 3.70172 3.25159 GeneID:201232,Genbank:NM_201566.2,HGNC:HGNC:31037 solute carrier family 16 member 13 GO:0000139,GO:0005794,GO:0005887,GO:0008028,GO:0015293,GO:0015718 Golgi membrane|Golgi apparatus|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport SLC16A14 92.6915326039519 82.1574737386034 103.2255914693 1.25643580275762 0.329336958994692 0.285810983940464 1 0.616086 0.647943 0.812361 0.730574 GeneID:151473,Genbank:NM_152527.4,HGNC:HGNC:26417 solute carrier family 16 member 14 GO:0005887,GO:0008028,GO:0015293,GO:0015718 integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport SLC16A2 4923.95641003134 5344.49559915024 4503.41722091245 0.842627173578079 -0.247033653287923 0.062431646441498 0.89203234548829 56.755 57.4924 53.114 45.1341 GeneID:6567,Genbank:NM_006517.4,HGNC:HGNC:10923,MIM:300095 solute carrier family 16 member 2 GO:0005215,GO:0005886,GO:0005887,GO:0006810,GO:0008028,GO:0015293,GO:0015349,GO:0015718,GO:0043252,GO:0070327 transporter activity|plasma membrane|integral component of plasma membrane|transport|monocarboxylic acid transmembrane transporter activity|symporter activity|thyroid hormone transmembrane transporter activity|monocarboxylic acid transport|sodium-independent organic anion transport|thyroid hormone transport hsa04919 Thyroid hormone signaling pathway SLC16A3 3517.43892551439 3732.45196242066 3302.42588860812 0.884787244915097 -0.176597507043466 0.294447313659116 1 75.8682 76.6349 63.7424 74.9936 GeneID:9123,Genbank:XM_024451023.1,HGNC:HGNC:10924,MIM:603877 solute carrier family 16 member 3 hsa05230 Central carbon metabolism in cancer SLC16A4 190.953221026937 202.597334758819 179.309107295054 0.88505165928521 -0.176166429048249 0.461631947303248 1 1.62611 1.60787 1.39038 1.52169 GeneID:9122,Genbank:NM_001201548.1,HGNC:HGNC:10925,MIM:603878 solute carrier family 16 member 4 GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016020 integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|membrane SLC16A6 6.51019818222685 7.68725495215503 5.33314141229868 0.693764086854385 -0.527482934369859 0.695767502138741 1 0.0728022 0.0787535 0.0799368 0.0278976 GeneID:9120,Genbank:XM_024451021.1,HGNC:HGNC:10927,MIM:603880 solute carrier family 16 member 6 GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0016020 integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|membrane SLC16A7 39.2834941142237 43.183101301186 35.3838869272615 0.819391981147258 -0.287374320711683 0.546105100641387 1 0.124013 0.122164 0.132843 0.0806073 GeneID:9194,Genbank:XM_011538989.2,HGNC:HGNC:10928,MIM:603654 solute carrier family 16 member 7 GO:0005477,GO:0005886,GO:0005887,GO:0008028,GO:0015129,GO:0015293,GO:0035873,GO:0050833,GO:1901475 pyruvate secondary active transmembrane transporter activity|plasma membrane|integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|lactate transmembrane transporter activity|symporter activity|lactate transmembrane transport|pyruvate transmembrane transporter activity|pyruvate transmembrane transport SLC16A8 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0 0.0392051 0.0431207 0 GeneID:23539,Genbank:NM_013356.2,HGNC:HGNC:16270,MIM:610409 solute carrier family 16 member 8 GO:0005886,GO:0005887,GO:0006090,GO:0008028,GO:0015129,GO:0015293,GO:0015727,GO:0016020,GO:0016021,GO:0050900 plasma membrane|integral component of plasma membrane|pyruvate metabolic process|monocarboxylic acid transmembrane transporter activity|lactate transmembrane transporter activity|symporter activity|lactate transport|membrane|integral component of membrane|leukocyte migration SLC16A9 161.86191548241 133.258152710261 190.465678254559 1.42929850354959 0.515307249266329 0.0330413424187972 0.717059810541268 1.50292 1.07394 1.81107 1.6651 GeneID:220963,Genbank:NM_001323977.1,HGNC:HGNC:23520,MIM:614242 solute carrier family 16 member 9 GO:0005887,GO:0008028,GO:0015293,GO:0015718,GO:0046415 integral component of plasma membrane|monocarboxylic acid transmembrane transporter activity|symporter activity|monocarboxylic acid transport|urate metabolic process SLC17A5 633.880268745641 703.681285924975 564.079251566306 0.801611841680336 -0.319024274219372 0.0546920740319958 0.852089744840899 9.65868 9.9554 7.59023 8.09516 GeneID:26503,Genbank:NM_012434.4,HGNC:HGNC:10933,MIM:604322 solute carrier family 17 member 5 GO:0005351,GO:0005765,GO:0005829,GO:0005886,GO:0005887,GO:0006811,GO:0006820,GO:0006865,GO:0015136,GO:0015538,GO:0015739,GO:0016020,GO:0030054,GO:0030672 sugar:proton symporter activity|lysosomal membrane|cytosol|plasma membrane|integral component of plasma membrane|ion transport|anion transport|amino acid transport|sialic acid transmembrane transporter activity|sialic acid:proton symporter activity|sialic acid transport|membrane|cell junction|synaptic vesicle membrane hsa04142 Lysosome SLC17A7 19.8893620645317 13.126066648371 26.6526574806924 2.03051364850416 1.02184472465849 0.121168580392728 1 0.147637 0.257813 0.341911 0.335238 GeneID:57030,Genbank:NM_020309.3,HGNC:HGNC:16704,MIM:605208 solute carrier family 17 member 7 GO:0003407,GO:0005313,GO:0005315,GO:0005886,GO:0006811,GO:0006817,GO:0007420,GO:0007616,GO:0008068,GO:0014047,GO:0015319,GO:0015321,GO:0016021,GO:0030054,GO:0030285,GO:0030672,GO:0035249,GO:0042137,GO:0044300,GO:0048786,GO:0051938,GO:0060076,GO:0060203,GO:0097401,GO:0098700,GO:0098794 neural retina development|L-glutamate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity|plasma membrane|ion transport|phosphate ion transport|brain development|long-term memory|extracellularly glutamate-gated chloride channel activity|glutamate secretion|sodium:inorganic phosphate symporter activity|sodium-dependent phosphate transmembrane transporter activity|integral component of membrane|cell junction|integral component of synaptic vesicle membrane|synaptic vesicle membrane|synaptic transmission, glutamatergic|sequestering of neurotransmitter|cerebellar mossy fiber|presynaptic active zone|L-glutamate import|excitatory synapse|clathrin-sculpted glutamate transport vesicle membrane|synaptic vesicle lumen acidification|neurotransmitter loading into synaptic vesicle|postsynapse hsa04721,hsa04723,hsa04724,hsa05033 Synaptic vesicle cycle|Retrograde endocannabinoid signaling|Glutamatergic synapse|Nicotine addiction SLC17A8 4.26479023381577 4.65077399104097 3.87880647659057 0.834013109229241 -0.261858034393229 0.950445554514575 1 0.0514045 0.0396047 0.0596243 0.018463 GeneID:246213,Genbank:NM_139319.2,HGNC:HGNC:20151,MIM:607557 solute carrier family 17 member 8 GO:0003407,GO:0005313,GO:0005771,GO:0006811,GO:0006814,GO:0007420,GO:0007605,GO:0015293,GO:0016021,GO:0030054,GO:0030672,GO:0043204,GO:0043679,GO:0060076,GO:0090102,GO:0097440,GO:0097441,GO:0097451,GO:1990030 neural retina development|L-glutamate transmembrane transporter activity|multivesicular body|ion transport|sodium ion transport|brain development|sensory perception of sound|symporter activity|integral component of membrane|cell junction|synaptic vesicle membrane|perikaryon|axon terminus|excitatory synapse|cochlea development|apical dendrite|basal dendrite|glial limiting end-foot|pericellular basket hsa04721,hsa04723,hsa04724,hsa05033 Synaptic vesicle cycle|Retrograde endocannabinoid signaling|Glutamatergic synapse|Nicotine addiction SLC18A2 6.76663090564743 6.26506702096788 7.26819479032697 1.16011445144989 0.214267141899404 0.899380970222127 1 0.0531473 0.0380333 0.0255167 0.0592589 GeneID:6571,Genbank:NM_003054.4,HGNC:HGNC:10935,MIM:193001 solute carrier family 18 member A2 hsa04721,hsa04726,hsa04728,hsa05012,hsa05030,hsa05031,hsa05034 Synaptic vesicle cycle|Serotonergic synapse|Dopaminergic synapse|Parkinson disease|Cocaine addiction|Amphetamine addiction|Alcoholism SLC18B1 575.284873657751 586.912056091886 563.657691223617 0.96037845086517 -0.0583250623922732 0.734801597202371 1 8.86937 9.20567 9.13971 8.02511 GeneID:116843,Genbank:NM_052831.2,HGNC:HGNC:21573,MIM:613361 solute carrier family 18 member B1 GO:0005887,GO:0022857 integral component of plasma membrane|transmembrane transporter activity SLC19A1 825.591047119526 845.213834539573 805.968259699479 0.953567282933232 -0.0685933573671777 0.656254054448186 1 4.75354 4.68752 4.99604 4.32589 GeneID:6573,Genbank:XM_017028445.2,HGNC:HGNC:10937,MIM:600424 solute carrier family 19 member 1 GO:0005542,GO:0005886,GO:0005887,GO:0008517,GO:0008518,GO:0015350,GO:0015884,GO:0016323,GO:0016324,GO:0046655,GO:0051958,GO:0098838 folic acid binding|plasma membrane|integral component of plasma membrane|folic acid transmembrane transporter activity|reduced folate carrier activity|methotrexate transmembrane transporter activity|folic acid transport|basolateral plasma membrane|apical plasma membrane|folic acid metabolic process|methotrexate transport|reduced folate transmembrane transport hsa01523,hsa04977 Antifolate resistance|Vitamin digestion and absorption SLC19A2 207.41640704039 246.673317968803 168.159496111976 0.681709304827381 -0.552771419990436 0.161201762673701 1 4.31712 2.89027 2.36676 2.41749 GeneID:10560,Genbank:NM_001319667.1,HGNC:HGNC:10938,MIM:603941 solute carrier family 19 member 2 GO:0005886,GO:0008517,GO:0015234,GO:0015888,GO:0016021,GO:0042723,GO:0071934 plasma membrane|folic acid transmembrane transporter activity|thiamine transmembrane transporter activity|thiamine transport|integral component of membrane|thiamine-containing compound metabolic process|thiamine transmembrane transport hsa04977 Vitamin digestion and absorption SLC19A3 18.8379543603627 16.3546527082248 21.3212560125006 1.30368136779683 0.382591304177106 0.588611949814999 1 0.0986928 0.130491 0.141282 0.160656 GeneID:80704,Genbank:XM_017005032.1,HGNC:HGNC:16266,MIM:606152 solute carrier family 19 member 3 GO:0005886,GO:0015234,GO:0015888,GO:0016021,GO:0042723,GO:0071934 plasma membrane|thiamine transmembrane transporter activity|thiamine transport|integral component of membrane|thiamine-containing compound metabolic process|thiamine transmembrane transport hsa04977 Vitamin digestion and absorption SLC1A1 379.740311600225 389.724107063959 369.756516136492 0.948764804215229 -0.0758776028427754 0.704109348940279 1 3.46305 3.15414 3.0548 3.25009 GeneID:6505,Genbank:NM_004170.5,HGNC:HGNC:10939,MIM:133550 solute carrier family 1 member 1 GO:0005313,GO:0005314,GO:0005886,GO:0005887,GO:0006811,GO:0007268,GO:0010460,GO:0014047,GO:0015108,GO:0015171,GO:0015501,GO:0016020,GO:0016324,GO:0016595,GO:0033229,GO:0042883,GO:0046872,GO:0051260,GO:0051938,GO:0070062,GO:0070779,GO:0089711,GO:0098712,GO:0140009,GO:0140016,GO:1902476 L-glutamate transmembrane transporter activity|high-affinity glutamate transmembrane transporter activity|plasma membrane|integral component of plasma membrane|ion transport|chemical synaptic transmission|positive regulation of heart rate|glutamate secretion|chloride transmembrane transporter activity|amino acid transmembrane transporter activity|glutamate:sodium symporter activity|membrane|apical plasma membrane|glutamate binding|cysteine transmembrane transporter activity|cysteine transport|metal ion binding|protein homooligomerization|L-glutamate import|extracellular exosome|D-aspartate import|L-glutamate transmembrane transport|L-glutamate import across plasma membrane|L-aspartate import across plasma membrane|D-aspartate import across plasma membrane|chloride transmembrane transport hsa04724,hsa04974 Glutamatergic synapse|Protein digestion and absorption SLC1A2 8.20619729717515 7.68725495215503 8.72513964219528 1.13501369429009 0.182709704181581 0.921878449448531 1 0.0207559 0.0264003 0.0265978 0.0185819 GeneID:6506,Genbank:NM_001195728.2,HGNC:HGNC:10940,MIM:600300 solute carrier family 1 member 2 GO:0005313,GO:0005314,GO:0005886,GO:0005887,GO:0006811,GO:0007268,GO:0007632,GO:0009611,GO:0009986,GO:0010259,GO:0014047,GO:0015171,GO:0015501,GO:0016020,GO:0021537,GO:0030534,GO:0030673,GO:0031668,GO:0035264,GO:0043200,GO:0046326,GO:0046872,GO:0070207,GO:0070779,GO:0089711,GO:0098712 L-glutamate transmembrane transporter activity|high-affinity glutamate transmembrane transporter activity|plasma membrane|integral component of plasma membrane|ion transport|chemical synaptic transmission|visual behavior|response to wounding|cell surface|multicellular organism aging|glutamate secretion|amino acid transmembrane transporter activity|glutamate:sodium symporter activity|membrane|telencephalon development|adult behavior|axolemma|cellular response to extracellular stimulus|multicellular organism growth|response to amino acid|positive regulation of glucose import|metal ion binding|protein homotrimerization|D-aspartate import|L-glutamate transmembrane transport|L-glutamate import across plasma membrane hsa04724,hsa05014 Glutamatergic synapse|Amyotrophic lateral sclerosis (ALS) SLC1A3 2456.84706258149 2462.38749100619 2451.30663415679 0.995499954052773 -0.00650684552906644 0.987725740152991 1 16.9757 15.9934 17.1742 15.6684 GeneID:6507,Genbank:NM_004172.4,HGNC:HGNC:10941,MIM:600111 solute carrier family 1 member 3 GO:0001504,GO:0005313,GO:0005314,GO:0005886,GO:0005887,GO:0006537,GO:0006811,GO:0007268,GO:0007605,GO:0009416,GO:0009449,GO:0009611,GO:0009986,GO:0014047,GO:0015171,GO:0015501,GO:0016020,GO:0016595,GO:0021545,GO:0031223,GO:0043005,GO:0043025,GO:0046677,GO:0046872,GO:0048667,GO:0050806,GO:0050885,GO:0051938,GO:0070779,GO:0071805,GO:0089711,GO:0098712,GO:0140009,GO:0140016,GO:1902476 neurotransmitter uptake|L-glutamate transmembrane transporter activity|high-affinity glutamate transmembrane transporter activity|plasma membrane|integral component of plasma membrane|glutamate biosynthetic process|ion transport|chemical synaptic transmission|sensory perception of sound|response to light stimulus|gamma-aminobutyric acid biosynthetic process|response to wounding|cell surface|glutamate secretion|amino acid transmembrane transporter activity|glutamate:sodium symporter activity|membrane|glutamate binding|cranial nerve development|auditory behavior|neuron projection|neuronal cell body|response to antibiotic|metal ion binding|cell morphogenesis involved in neuron differentiation|positive regulation of synaptic transmission|neuromuscular process controlling balance|L-glutamate import|D-aspartate import|potassium ion transmembrane transport|L-glutamate transmembrane transport|L-glutamate import across plasma membrane|L-aspartate import across plasma membrane|D-aspartate import across plasma membrane|chloride transmembrane transport hsa04724 Glutamatergic synapse SLC1A4 1074.0838399743 1058.29477383824 1089.87290611036 1.02983869244445 0.0424183802869158 0.788107804694746 1 9.43974 9.72678 9.65254 10.3261 GeneID:6509,Genbank:NM_001348406.1,HGNC:HGNC:10942,MIM:600229 solute carrier family 1 member 4 GO:0005254,GO:0005813,GO:0005815,GO:0005882,GO:0005886,GO:0005887,GO:0006865,GO:0006868,GO:0009986,GO:0015171,GO:0015180,GO:0015184,GO:0015186,GO:0015193,GO:0015194,GO:0015195,GO:0015293,GO:0015808,GO:0015811,GO:0015824,GO:0015825,GO:0015826,GO:0016020,GO:0016021,GO:0030425,GO:0034589,GO:0034590,GO:0035249,GO:0042470,GO:0043025,GO:0050890,GO:0070062 chloride channel activity|centrosome|microtubule organizing center|intermediate filament|plasma membrane|integral component of plasma membrane|amino acid transport|glutamine transport|cell surface|amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|symporter activity|L-alanine transport|L-cystine transport|proline transport|L-serine transport|threonine transport|membrane|integral component of membrane|dendrite|hydroxyproline transport|L-hydroxyproline transmembrane transporter activity|synaptic transmission, glutamatergic|melanosome|neuronal cell body|cognition|extracellular exosome SLC1A5 7475.64091001667 7336.84445245384 7614.4373675795 1.03783546413238 0.0535777405207438 0.726204492269725 1 73.6737 77.6686 74.9173 83.3032 GeneID:6510,Genbank:XM_005259167.4,HGNC:HGNC:10943,MIM:109190 solute carrier family 1 member 5 GO:0001618,GO:0004872,GO:0005886,GO:0005887,GO:0006865,GO:0006868,GO:0010585,GO:0015171,GO:0015175,GO:0015186,GO:0015194,GO:0015293,GO:0015804,GO:0016020,GO:0042470,GO:0070062,GO:1903803 virus receptor activity|receptor activity|plasma membrane|integral component of plasma membrane|amino acid transport|glutamine transport|glutamine secretion|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-serine transmembrane transporter activity|symporter activity|neutral amino acid transport|membrane|melanosome|extracellular exosome|L-glutamine import across plasma membrane hsa04974,hsa05230 Protein digestion and absorption|Central carbon metabolism in cancer SLC20A1 5202.96309665334 5401.02528116301 5004.90091214368 0.926657560667068 -0.109891794655479 0.406225088323777 1 68.9492 70.2999 69.2158 61.6292 GeneID:6574,Genbank:NM_005415.4,HGNC:HGNC:10946,MIM:137570 solute carrier family 20 member 1 GO:0004871,GO:0004872,GO:0005315,GO:0005316,GO:0005436,GO:0005886,GO:0005887,GO:0006796,GO:0006810,GO:0006811,GO:0015319,GO:0015321,GO:0016020,GO:0043123 signal transducer activity|receptor activity|inorganic phosphate transmembrane transporter activity|high-affinity inorganic phosphate:sodium symporter activity|sodium:phosphate symporter activity|plasma membrane|integral component of plasma membrane|phosphate-containing compound metabolic process|transport|ion transport|sodium:inorganic phosphate symporter activity|sodium-dependent phosphate transmembrane transporter activity|membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling SLC20A2 1207.99948294116 1233.49715336298 1182.50181251934 0.958657917689867 -0.060911991317072 0.673767092606636 1 8.31295 8.65374 8.29955 7.89975 GeneID:6575,Genbank:NM_006749.4,HGNC:HGNC:10947,MIM:158378 solute carrier family 20 member 2 GO:0001618,GO:0004872,GO:0005315,GO:0005436,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0015319,GO:0015321,GO:0016020,GO:0070062 virus receptor activity|receptor activity|inorganic phosphate transmembrane transporter activity|sodium:phosphate symporter activity|plasma membrane|integral component of plasma membrane|transport|ion transport|sodium:inorganic phosphate symporter activity|sodium-dependent phosphate transmembrane transporter activity|membrane|extracellular exosome SLC22A1 11.588769608008 15.422536178995 7.75500303702094 0.5028357818076 -0.991840779258586 0.252679835948514 1 0.0417837 0.115845 0.0696152 0.0277636 GeneID:6580,Genbank:XM_005267102.5,HGNC:HGNC:10963,MIM:602607 solute carrier family 22 member 1 GO:0005277,GO:0005329,GO:0005333,GO:0005886,GO:0005887,GO:0006836,GO:0006855,GO:0008513,GO:0008514,GO:0010248,GO:0015101,GO:0015651,GO:0015695,GO:0015872,GO:0015874,GO:0016020,GO:0016323,GO:0042803,GO:0048241,GO:0051260 acetylcholine transmembrane transporter activity|dopamine transmembrane transporter activity|norepinephrine transmembrane transporter activity|plasma membrane|integral component of plasma membrane|neurotransmitter transport|drug transmembrane transport|secondary active organic cation transmembrane transporter activity|organic anion transmembrane transporter activity|establishment or maintenance of transmembrane electrochemical gradient|organic cation transmembrane transporter activity|quaternary ammonium group transmembrane transporter activity|organic cation transport|dopamine transport|norepinephrine transport|membrane|basolateral plasma membrane|protein homodimerization activity|epinephrine transport|protein homooligomerization hsa04976,hsa05231 Bile secretion|Choline metabolism in cancer SLC22A13 2.50858371530865 2.59443583384164 2.42273159677566 0.933818275701299 -0.0987862711331069 1 1 0.0332649 0 0.0207837 0.00970543 GeneID:9390,Genbank:NM_004256.3,HGNC:HGNC:8494,MIM:604047 solute carrier family 22 member 13 GO:0005452,GO:0005886,GO:0005887,GO:0015101,GO:0015347,GO:0015695,GO:0015747,GO:0016324,GO:0034356,GO:0043252,GO:0070062,GO:0090416,GO:2001142 inorganic anion exchanger activity|plasma membrane|integral component of plasma membrane|organic cation transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|organic cation transport|urate transport|apical plasma membrane|NAD biosynthesis via nicotinamide riboside salvage pathway|sodium-independent organic anion transport|extracellular exosome|nicotinate transmembrane transporter activity|nicotinate transport SLC22A14 3.2382527328478 3.084507235799 3.3919982298966 1.0996888548449 0.137095386413358 1 1 0.0288581 0.0257666 0.0270516 0.0252153 GeneID:9389,Genbank:XM_011534245.2,HGNC:HGNC:8495,MIM:604048 solute carrier family 22 member 14 GO:0005452,GO:0005887,GO:0015101,GO:0015347,GO:0015695,GO:0043252 inorganic anion exchanger activity|integral component of plasma membrane|organic cation transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|organic cation transport|sodium-independent organic anion transport SLC22A15 88.6048759373223 88.0285219069838 89.1812299676607 1.01309471107438 0.0187690535172771 0.959372315349985 1 0.466453 0.407996 0.473371 0.39195 GeneID:55356,Genbank:NM_018420.2,HGNC:HGNC:20301,MIM:608275 solute carrier family 22 member 15 GO:0008514,GO:0016021 organic anion transmembrane transporter activity|integral component of membrane SLC22A17 115.823883309178 112.426230800374 119.221535817983 1.06044234489791 0.0846661852333999 0.791785998398442 1 0.713499 0.946553 0.995697 0.953395 GeneID:51310,Genbank:XM_005267748.4,HGNC:HGNC:23095,MIM:611461 solute carrier family 22 member 17 GO:0004888,GO:0005774,GO:0005887,GO:0008514,GO:0015891,GO:0016021,GO:0031301,GO:0055072 transmembrane signaling receptor activity|vacuolar membrane|integral component of plasma membrane|organic anion transmembrane transporter activity|siderophore transport|integral component of membrane|integral component of organelle membrane|iron ion homeostasis SLC22A18 261.907713803272 227.70664611823 296.108781488315 1.30039586694614 0.378950875824249 0.077128520715511 0.94157495521624 3.43591 3.87054 5.07323 4.68704 GeneID:5002,Genbank:NM_183233.2,HGNC:HGNC:10964,MIM:602631 solute carrier family 22 member 18 GO:0005635,GO:0005737,GO:0005886,GO:0007588,GO:0015238,GO:0015293,GO:0015307,GO:0015695,GO:0015893,GO:0016020,GO:0016021,GO:0016324,GO:0031625 nuclear envelope|cytoplasm|plasma membrane|excretion|drug transmembrane transporter activity|symporter activity|drug:proton antiporter activity|organic cation transport|drug transport|membrane|integral component of membrane|apical plasma membrane|ubiquitin protein ligase binding SLC22A18AS 21.2349457818839 21.1495055233206 21.3203860404472 1.00807964597272 0.0116096272411781 1 1 0.132304 0.080694 0.100392 0.101214 GeneID:5003,Genbank:XM_017017834.1,HGNC:HGNC:10965,MIM:603240 solute carrier family 22 member 18 antisense SLC22A23 1094.12077448512 1033.82062970569 1154.42091926454 1.11665494583251 0.159183451853974 0.29729394971169 1 4.07542 4.32273 4.97637 4.44276 GeneID:63027,Genbank:XM_011514801.2,HGNC:HGNC:21106,MIM:611697 solute carrier family 22 member 23 GO:0008514,GO:0016021 organic anion transmembrane transporter activity|integral component of membrane SLC22A3 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0.00284045 0 0.00271417 0.00253111 GeneID:6581,Genbank:NM_021977.3,HGNC:HGNC:10967,MIM:604842 solute carrier family 22 member 3 GO:0005329,GO:0005886,GO:0005887,GO:0006855,GO:0008514,GO:0015101,GO:0015651,GO:0015695,GO:0015697,GO:0015872,GO:0016020,GO:0019534,GO:0032098,GO:0051615 dopamine transmembrane transporter activity|plasma membrane|integral component of plasma membrane|drug transmembrane transport|organic anion transmembrane transporter activity|organic cation transmembrane transporter activity|quaternary ammonium group transmembrane transporter activity|organic cation transport|quaternary ammonium group transport|dopamine transport|membrane|toxin transmembrane transporter activity|regulation of appetite|histamine uptake hsa05231 Choline metabolism in cancer SLC22A4 74.510931062919 80.6872595327313 68.3346025931066 0.846906971296828 -0.239724589815998 0.492446886862465 1 1.38995 1.12191 1.1431 0.95602 GeneID:6583,Genbank:XM_011543589.2,HGNC:HGNC:10968,MIM:604190 solute carrier family 22 member 4 GO:0000166,GO:0005524,GO:0005739,GO:0005886,GO:0005887,GO:0006641,GO:0006814,GO:0007589,GO:0008513,GO:0008514,GO:0009437,GO:0015226,GO:0015293,GO:0015491,GO:0015651,GO:0015695,GO:0015697,GO:0015879,GO:0016324,GO:0030165 nucleotide binding|ATP binding|mitochondrion|plasma membrane|integral component of plasma membrane|triglyceride metabolic process|sodium ion transport|body fluid secretion|secondary active organic cation transmembrane transporter activity|organic anion transmembrane transporter activity|carnitine metabolic process|carnitine transmembrane transporter activity|symporter activity|cation:cation antiporter activity|quaternary ammonium group transmembrane transporter activity|organic cation transport|quaternary ammonium group transport|carnitine transport|apical plasma membrane|PDZ domain binding hsa05231 Choline metabolism in cancer SLC22A5 223.528440016954 235.758493957649 211.298386076259 0.896249303807547 -0.158028001735347 0.472695105533929 1 2.82901 2.78106 2.67595 2.61874 GeneID:6584,Genbank:NM_001308122.1,HGNC:HGNC:10969,MIM:603377 solute carrier family 22 member 5 hsa05231 Choline metabolism in cancer SLC23A2 1093.77870906244 1065.09793853585 1122.45947958904 1.05385564930493 0.075677268973277 0.623232017146947 1 6.19434 6.50667 7.36282 6.22222 GeneID:9962,Genbank:NM_203327.1,HGNC:HGNC:10973,MIM:603791 solute carrier family 23 member 2 GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006979,GO:0008520,GO:0008523,GO:0009925,GO:0015205,GO:0015229,GO:0015851,GO:0015882,GO:0015993,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0019852,GO:0070890,GO:0070904 cytoplasm|plasma membrane|integral component of plasma membrane|nucleobase-containing compound metabolic process|response to oxidative stress|L-ascorbate:sodium symporter activity|sodium-dependent multivitamin transmembrane transporter activity|basal plasma membrane|nucleobase transmembrane transporter activity|L-ascorbic acid transmembrane transporter activity|nucleobase transport|L-ascorbic acid transport|molecular hydrogen transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|L-ascorbic acid metabolic process|sodium-dependent L-ascorbate transmembrane transporter activity|transepithelial L-ascorbic acid transport SLC23A3 3.90869268535663 1.02816907859967 6.78921629211359 6.60320995196654 2.72316751780365 0.262851451613301 1 0 0.0207511 0.087268 0 GeneID:151295,Genbank:NM_144712.4,HGNC:HGNC:20601 solute carrier family 23 member 3 GO:0016021,GO:0022857 integral component of membrane|transmembrane transporter activity SLC24A1 210.750844100394 178.219243175645 243.282445025143 1.36507394313966 0.448979100970474 0.044312443587107 0.785206567052859 0.4917 0.482113 0.745211 0.664782 GeneID:9187,Genbank:XM_024450105.1,HGNC:HGNC:10975,MIM:603617 solute carrier family 24 member 1 GO:0005262,GO:0005509,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006816,GO:0006874,GO:0007601,GO:0008273,GO:0009642,GO:0015293,GO:0016020,GO:0019867,GO:0030955,GO:0031402,GO:0060291,GO:0060292 calcium channel activity|calcium ion binding|plasma membrane|integral component of plasma membrane|transport|ion transport|calcium ion transport|cellular calcium ion homeostasis|visual perception|calcium, potassium:sodium antiporter activity|response to light intensity|symporter activity|membrane|outer membrane|potassium ion binding|sodium ion binding|long-term synaptic potentiation|long term synaptic depression hsa04744 Phototransduction SLC24A2 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0059798 0 0 GeneID:25769,Genbank:XM_017014592.1,HGNC:HGNC:10976,MIM:609838 solute carrier family 24 member 2 GO:0005262,GO:0005509,GO:0005886,GO:0005887,GO:0006811,GO:0006874,GO:0007601,GO:0007612,GO:0007613,GO:0008273,GO:0015293,GO:0016151,GO:0030145,GO:0030955,GO:0031402,GO:0034220,GO:0046870,GO:0046983,GO:0050896,GO:0060291,GO:0060292 calcium channel activity|calcium ion binding|plasma membrane|integral component of plasma membrane|ion transport|cellular calcium ion homeostasis|visual perception|learning|memory|calcium, potassium:sodium antiporter activity|symporter activity|nickel cation binding|manganese ion binding|potassium ion binding|sodium ion binding|ion transmembrane transport|cadmium ion binding|protein dimerization activity|response to stimulus|long-term synaptic potentiation|long term synaptic depression SLC24A4 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.00688758 0 0 GeneID:123041,Genbank:NM_153648.3,HGNC:HGNC:10978,MIM:609840 solute carrier family 24 member 4 GO:0005262,GO:0005509,GO:0005737,GO:0005886,GO:0005887,GO:0006811,GO:0006874,GO:0007608,GO:0008273,GO:0015293,GO:0016020,GO:0030955,GO:0031402,GO:0050896,GO:0097186 calcium channel activity|calcium ion binding|cytoplasm|plasma membrane|integral component of plasma membrane|ion transport|cellular calcium ion homeostasis|sensory perception of smell|calcium, potassium:sodium antiporter activity|symporter activity|membrane|potassium ion binding|sodium ion binding|response to stimulus|amelogenesis hsa04740 Olfactory transduction SLC24A5 15.8261655880839 20.9956180441578 10.65671313201 0.507568441643246 -0.978325723305186 0.424005270017134 1 0.185722 0.0254269 0.0255553 0.0952676 GeneID:283652,Genbank:NM_205850.2,HGNC:HGNC:20611,MIM:609802 solute carrier family 24 member 5 SLC25A1 1832.45496587479 1720.66024252305 1944.24968922652 1.12994398381381 0.176251253811123 0.31496148710005 1 36.7527 40.9297 42.822 45.1423 GeneID:6576,Genbank:NM_005984.4,HGNC:HGNC:10979,MIM:190315 solute carrier family 25 member 1 GO:0005634,GO:0005743,GO:0006094,GO:0006839,GO:0006843,GO:0015137,GO:0015142,GO:0016021,GO:0046949,GO:0070062 nucleus|mitochondrial inner membrane|gluconeogenesis|mitochondrial transport|mitochondrial citrate transport|citrate transmembrane transporter activity|tricarboxylic acid transmembrane transporter activity|integral component of membrane|fatty-acyl-CoA biosynthetic process|extracellular exosome SLC25A10 1380.07052026013 1371.71487202347 1388.42616849679 1.01218277705823 0.0174698312829466 0.930947454723381 1 27.0744 28.334 27.9208 29.069 GeneID:1468,Genbank:NM_001270888.1,HGNC:HGNC:10980,MIM:606794 solute carrier family 25 member 10 GO:0005310,GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0006094,GO:0006811,GO:0006835,GO:0006839,GO:0008272,GO:0015116,GO:0015117,GO:0015131,GO:0015140,GO:0015141,GO:0015297,GO:0015709,GO:0015729,GO:0016021,GO:0035435,GO:0070221,GO:0071422,GO:0071423 dicarboxylic acid transmembrane transporter activity|nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|gluconeogenesis|ion transport|dicarboxylic acid transport|mitochondrial transport|sulfate transport|sulfate transmembrane transporter activity|thiosulfate transmembrane transporter activity|oxaloacetate transmembrane transporter activity|malate transmembrane transporter activity|succinate transmembrane transporter activity|antiporter activity|thiosulfate transport|oxaloacetate transport|integral component of membrane|phosphate ion transmembrane transport|sulfide oxidation, using sulfide:quinone oxidoreductase|succinate transmembrane transport|malate transmembrane transport hsa04964 Proximal tubule bicarbonate reclamation SLC25A11 3348.75735839888 3439.60810546509 3257.90661133267 0.947173780104854 -0.0782989504030451 0.635185218143586 1 73.929 81.1366 69.9401 79.363 GeneID:8402,Genbank:NM_001165417.1,HGNC:HGNC:10981,MIM:604165 solute carrier family 25 member 11 GO:0003723,GO:0005634,GO:0005739,GO:0005743,GO:0005887,GO:0006094,GO:0006810,GO:0006839,GO:0015367 RNA binding|nucleus|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|gluconeogenesis|transport|mitochondrial transport|oxoglutarate:malate antiporter activity SLC25A12 564.348120326025 534.071605575607 594.624635076444 1.11337998288745 0.154946050783957 0.357694457181464 1 4.86045 4.63158 5.45885 5.35803 GeneID:8604,Genbank:NM_003705.4,HGNC:HGNC:10982,MIM:603667 solute carrier family 25 member 12 GO:0005313,GO:0005509,GO:0005739,GO:0005743,GO:0006094,GO:0015172,GO:0015183,GO:0015810,GO:0015813,GO:0016021,GO:0043209,GO:0043490,GO:0051592 L-glutamate transmembrane transporter activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|gluconeogenesis|acidic amino acid transmembrane transporter activity|L-aspartate transmembrane transporter activity|aspartate transport|L-glutamate transport|integral component of membrane|myelin sheath|malate-aspartate shuttle|response to calcium ion SLC25A13 2287.59511667462 2180.10367382963 2395.08655951961 1.09861131297134 0.135681053225751 0.323254718487333 1 20.122 19.1246 23.1269 21.3888 GeneID:10165,Genbank:NM_014251.2,HGNC:HGNC:10983,MIM:603859 solute carrier family 25 member 13 GO:0005215,GO:0005313,GO:0005509,GO:0005739,GO:0005743,GO:0005887,GO:0006094,GO:0006754,GO:0006839,GO:0015172,GO:0015183,GO:0015810,GO:0015813,GO:0016021,GO:0043490,GO:0045333,GO:0051592 transporter activity|L-glutamate transmembrane transporter activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|gluconeogenesis|ATP biosynthetic process|mitochondrial transport|acidic amino acid transmembrane transporter activity|L-aspartate transmembrane transporter activity|aspartate transport|L-glutamate transport|integral component of membrane|malate-aspartate shuttle|cellular respiration|response to calcium ion SLC25A14 423.359040709835 447.39762801491 399.320453404761 0.892540390025163 -0.164010638159596 0.379919710166921 1 3.1404 2.48128 2.54333 2.55174 GeneID:9016,Genbank:NM_001282195.1,HGNC:HGNC:10984,MIM:300242 solute carrier family 25 member 14 GO:0005739,GO:0005743,GO:0005887,GO:0006810,GO:0006839,GO:0009060,GO:0015992,GO:0022857 mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|transport|mitochondrial transport|aerobic respiration|proton transport|transmembrane transporter activity SLC25A15 648.944430987894 696.503719684993 601.385142290795 0.863434214770285 -0.211841832176721 0.196444815214129 1 7.37168 7.72918 6.23466 6.89629 GeneID:10166,Genbank:NM_014252.3,HGNC:HGNC:10985,MIM:603861 solute carrier family 25 member 15 GO:0000050,GO:0000064,GO:0000066,GO:0005743,GO:0006839,GO:0016021 urea cycle|L-ornithine transmembrane transporter activity|mitochondrial ornithine transport|mitochondrial inner membrane|mitochondrial transport|integral component of membrane SLC25A16 216.273041772506 199.426583628758 233.119499916254 1.16894897196964 0.225211953399815 0.315104372672557 1 2.13544 2.46583 3.15367 2.46841 GeneID:8034,Genbank:NM_001324317.1,HGNC:HGNC:10986,MIM:139080 solute carrier family 25 member 16 GO:0005739,GO:0005743,GO:0006839,GO:0009108,GO:0015291,GO:0015297,GO:0016021,GO:0022857 mitochondrion|mitochondrial inner membrane|mitochondrial transport|coenzyme biosynthetic process|secondary active transmembrane transporter activity|antiporter activity|integral component of membrane|transmembrane transporter activity SLC25A17 884.258255577088 917.071017182819 851.445493971358 0.928440085901898 -0.107119281723061 0.476080104126952 1 14.2707 17.4559 14.4019 15.194 GeneID:10478,Genbank:NM_001282727.1,HGNC:HGNC:10987,MIM:606795 solute carrier family 25 member 17 GO:0000295,GO:0001561,GO:0005347,GO:0005743,GO:0005777,GO:0005778,GO:0005779,GO:0006635,GO:0006839,GO:0015217,GO:0015228,GO:0015230,GO:0015867,GO:0015908,GO:0016020,GO:0044610,GO:0051087,GO:0051724,GO:0080122 adenine nucleotide transmembrane transporter activity|fatty acid alpha-oxidation|ATP transmembrane transporter activity|mitochondrial inner membrane|peroxisome|peroxisomal membrane|integral component of peroxisomal membrane|fatty acid beta-oxidation|mitochondrial transport|ADP transmembrane transporter activity|coenzyme A transmembrane transporter activity|FAD transmembrane transporter activity|ATP transport|fatty acid transport|membrane|FMN transmembrane transporter activity|chaperone binding|NAD transmembrane transporter activity|AMP transmembrane transporter activity hsa04146 Peroxisome SLC25A18 10.8827742020649 9.64754055998448 12.1180078441453 1.25607223611038 0.32891943531353 0.763281230840274 1 0.0501094 0.0904752 0.129291 0.0549077 GeneID:83733,Genbank:XM_011546150.2,HGNC:HGNC:10988,MIM:609303 solute carrier family 25 member 18 GO:0005280,GO:0005314,GO:0005743,GO:0006811,GO:0006839,GO:0016021 hydrogen:amino acid symporter activity|high-affinity glutamate transmembrane transporter activity|mitochondrial inner membrane|ion transport|mitochondrial transport|integral component of membrane SLC25A19 485.553250520231 544.63266235546 426.473838685001 0.783048590660283 -0.352826260768788 0.0426353290534583 0.77030864790227 4.58925 5.27612 3.78412 4.0046 GeneID:60386,Genbank:XM_017024927.2,HGNC:HGNC:14409,MIM:606521 solute carrier family 25 member 19 GO:0005634,GO:0005743,GO:0006839,GO:0015234,GO:0030233,GO:0030302,GO:0030974,GO:0031305,GO:0042723,GO:0090422 nucleus|mitochondrial inner membrane|mitochondrial transport|thiamine transmembrane transporter activity|deoxynucleotide transmembrane transporter activity|deoxynucleotide transport|thiamine pyrophosphate transmembrane transport|integral component of mitochondrial inner membrane|thiamine-containing compound metabolic process|thiamine pyrophosphate transmembrane transporter activity SLC25A2 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0342954 0.0314871 0 0 GeneID:83884,Genbank:NM_031947.3,HGNC:HGNC:22921,MIM:608157 solute carrier family 25 member 2 GO:0000050,GO:0000064,GO:0000066,GO:0005743,GO:0006839,GO:0016021 urea cycle|L-ornithine transmembrane transporter activity|mitochondrial ornithine transport|mitochondrial inner membrane|mitochondrial transport|integral component of membrane SLC25A20 1042.40916479236 945.974404242341 1138.84392534238 1.20388450283126 0.267696990781011 0.0793615118089712 0.945472338172662 18.516 18.6611 22.2435 22.5411 GeneID:788,Genbank:NM_000387.5,HGNC:HGNC:1421,MIM:613698 solute carrier family 25 member 20 GO:0005476,GO:0005739,GO:0005743,GO:0005829,GO:0006839,GO:0006853,GO:0015226,GO:0015227,GO:0015879,GO:0016021 carnitine:acyl carnitine antiporter activity|mitochondrion|mitochondrial inner membrane|cytosol|mitochondrial transport|carnitine shuttle|carnitine transmembrane transporter activity|acyl carnitine transmembrane transporter activity|carnitine transport|integral component of membrane hsa04714 Thermogenesis SLC25A21 1.53431398281751 1.61429302992691 1.45433493570811 0.90091136413688 -0.150542920935571 1 1 0.0186043 0 0 0.00839078 GeneID:89874,Genbank:XM_011537287.3,HGNC:HGNC:14411,MIM:607571 solute carrier family 25 member 21 GO:0005310,GO:0005743,GO:0006554,GO:0006835,GO:0006839,GO:0015139,GO:0016021 dicarboxylic acid transmembrane transporter activity|mitochondrial inner membrane|lysine catabolic process|dicarboxylic acid transport|mitochondrial transport|alpha-ketoglutarate transmembrane transporter activity|integral component of membrane SLC25A22 482.352875541265 515.921380394678 448.784370687851 0.869869688952476 -0.201128801032846 0.245802422422422 1 5.86594 6.72595 5.96233 5.10539 GeneID:79751,Genbank:XM_011520371.2,HGNC:HGNC:19954,MIM:609302 solute carrier family 25 member 22 GO:0005280,GO:0005313,GO:0005314,GO:0005743,GO:0006811,GO:0006839,GO:0015813,GO:0016021 hydrogen:amino acid symporter activity|L-glutamate transmembrane transporter activity|high-affinity glutamate transmembrane transporter activity|mitochondrial inner membrane|ion transport|mitochondrial transport|L-glutamate transport|integral component of membrane SLC25A23 1386.25897284896 1364.18048754962 1408.3374581483 1.03236886247948 0.0459585337356444 0.765507723222746 1 9.86863 10.1867 10.8145 10.3386 GeneID:79085,Genbank:XM_017027287.2,HGNC:HGNC:19375,MIM:608746 solute carrier family 25 member 23 GO:0002082,GO:0005347,GO:0005509,GO:0005739,GO:0005743,GO:0006839,GO:0006851,GO:0015217,GO:0016021,GO:0036444,GO:0043457,GO:0051282,GO:0071277,GO:0097274 regulation of oxidative phosphorylation|ATP transmembrane transporter activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial transport|mitochondrial calcium ion transmembrane transport|ADP transmembrane transporter activity|integral component of membrane|mitochondrial calcium uptake|regulation of cellular respiration|regulation of sequestering of calcium ion|cellular response to calcium ion|urea homeostasis SLC25A24 1013.03325999314 1072.18722687986 953.87929310643 0.889657393030402 -0.168678233568868 0.503065007407942 1 11.039 9.84227 10.8233 7.71866 GeneID:29957,Genbank:NM_013386.4,HGNC:HGNC:20662,MIM:608744 solute carrier family 25 member 24 GO:0005347,GO:0005509,GO:0005739,GO:0005743,GO:0006839,GO:0010941,GO:0015217,GO:0015867,GO:0016021,GO:0034599,GO:0071277 ATP transmembrane transporter activity|calcium ion binding|mitochondrion|mitochondrial inner membrane|mitochondrial transport|regulation of cell death|ADP transmembrane transporter activity|ATP transport|integral component of membrane|cellular response to oxidative stress|cellular response to calcium ion SLC25A25 693.370819324045 629.691329885376 757.050308762714 1.20225620527524 0.265744372499096 0.100183307798334 1 4.57907 4.20983 5.90386 4.66811 GeneID:114789,Genbank:NM_001006641.3,HGNC:HGNC:20663,MIM:608745 solute carrier family 25 member 25 GO:0005347,GO:0005509,GO:0005743,GO:0006839,GO:0015217,GO:0016021 ATP transmembrane transporter activity|calcium ion binding|mitochondrial inner membrane|mitochondrial transport|ADP transmembrane transporter activity|integral component of membrane SLC25A26 444.920578776047 474.553468876412 415.287688675681 0.875112534018446 -0.192459544421081 0.281456099383717 1 2.03227 2.23322 1.77053 2.13006 GeneID:115286,Genbank:NM_173471.3,HGNC:HGNC:20661,MIM:611037 solute carrier family 25 member 26 GO:0000095,GO:0005739,GO:0005743,GO:0006811,GO:0006839,GO:0015805,GO:0016021 S-adenosyl-L-methionine transmembrane transporter activity|mitochondrion|mitochondrial inner membrane|ion transport|mitochondrial transport|S-adenosyl-L-methionine transport|integral component of membrane SLC25A27 24.7223433220471 20.3614678181456 29.0832188259487 1.4283458877179 0.514345384178177 0.36992676119301 1 0.260403 0.124178 0.418279 0.259162 GeneID:9481,Genbank:NM_004277.4,HGNC:HGNC:21065,MIM:613725 solute carrier family 25 member 27 GO:0005739,GO:0005743,GO:0006839,GO:0008284,GO:0009409,GO:0010917,GO:0015992,GO:0016021,GO:0022857,GO:0031966,GO:0035356,GO:0043025,GO:0043066,GO:0045177,GO:0046324,GO:0048839,GO:0051562,GO:0051881,GO:0070997 mitochondrion|mitochondrial inner membrane|mitochondrial transport|positive regulation of cell proliferation|response to cold|negative regulation of mitochondrial membrane potential|proton transport|integral component of membrane|transmembrane transporter activity|mitochondrial membrane|cellular triglyceride homeostasis|neuronal cell body|negative regulation of apoptotic process|apical part of cell|regulation of glucose import|inner ear development|negative regulation of mitochondrial calcium ion concentration|regulation of mitochondrial membrane potential|neuron death SLC25A28 696.312522048254 671.45326025623 721.171783840278 1.07404614219175 0.103055974404567 0.542535254027158 1 3.93217 4.18387 4.70481 4.04027 GeneID:81894,Genbank:NM_031212.3,HGNC:HGNC:23472,MIM:609767 solute carrier family 25 member 28 GO:0005381,GO:0005743,GO:0006839,GO:0016021,GO:0048250,GO:0055072 iron ion transmembrane transporter activity|mitochondrial inner membrane|mitochondrial transport|integral component of membrane|mitochondrial iron ion transport|iron ion homeostasis SLC25A29 899.093430706284 819.721329983537 978.465531429031 1.19365630201264 0.255387490905821 0.105081068365138 1 6.81288 7.1803 8.9175 8.32743 GeneID:123096,Genbank:NM_152333.3,HGNC:HGNC:20116,MIM:615064 solute carrier family 25 member 29 GO:0005289,GO:0005292,GO:0005739,GO:0005743,GO:0006839,GO:0006865,GO:0015171,GO:0015174,GO:0015227,GO:0015822,GO:0016021,GO:0089709,GO:1903400,GO:1903401,GO:1990575 high-affinity arginine transmembrane transporter activity|high-affinity lysine transmembrane transporter activity|mitochondrion|mitochondrial inner membrane|mitochondrial transport|amino acid transport|amino acid transmembrane transporter activity|basic amino acid transmembrane transporter activity|acyl carnitine transmembrane transporter activity|ornithine transport|integral component of membrane|L-histidine transmembrane transport|L-arginine transmembrane transport|L-lysine transmembrane transport|mitochondrial L-ornithine transmembrane transport hsa04714 Thermogenesis SLC25A3 11997.3511298748 11923.2266904457 12071.4755693039 1.01243362075612 0.017827322174774 0.910375836224982 1 201.758 222.657 212.769 226.549 GeneID:5250,Genbank:NM_213611.2,HGNC:HGNC:10989,MIM:600370 solute carrier family 25 member 3 GO:0005743,GO:0015293,GO:0016021 mitochondrial inner membrane|symporter activity|integral component of membrane SLC25A30 489.632403150601 506.213970903192 473.05083539801 0.934487909438747 -0.0977520966265069 0.72499178277433 1 4.55636 3.65898 4.57032 3.42809 GeneID:253512,Genbank:NM_001286806.1,HGNC:HGNC:27371,MIM:610793 solute carrier family 25 member 30 GO:0005739,GO:0005743,GO:0006839,GO:0016021,GO:0022857 mitochondrion|mitochondrial inner membrane|mitochondrial transport|integral component of membrane|transmembrane transporter activity SLC25A31 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0346689 0 GeneID:83447,Genbank:XM_011532298.2,HGNC:HGNC:25319,MIM:610796 solute carrier family 25 member 31 GO:0005634,GO:0005739,GO:0005743,GO:0006839,GO:0016021,GO:0022857,GO:0031514 nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial transport|integral component of membrane|transmembrane transporter activity|motile cilium hsa04020,hsa04022,hsa04217,hsa04218,hsa05012,hsa05016,hsa05166 Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|Parkinson disease|Huntington disease|Human T-cell leukemia virus 1 infection SLC25A32 873.742132598547 979.798122631652 767.686142565442 0.783514608604785 -0.351967920935903 0.0237322804641171 0.61999072858338 14.5729 15.5654 12.7511 10.9326 GeneID:81034,Genbank:NM_030780.4,HGNC:HGNC:29683,MIM:610815 solute carrier family 25 member 32 GO:0005739,GO:0005743,GO:0006544,GO:0006839,GO:0008517,GO:0015230,GO:0015884,GO:0016021,GO:0046655,GO:1904947 mitochondrion|mitochondrial inner membrane|glycine metabolic process|mitochondrial transport|folic acid transmembrane transporter activity|FAD transmembrane transporter activity|folic acid transport|integral component of membrane|folic acid metabolic process|folic acid import into mitochondrion SLC25A33 534.442203160758 541.106109992389 527.778296329128 0.975369315893608 -0.0359795074883906 0.825478145212388 1 12.7409 12.9673 13.5226 12.1263 GeneID:84275,Genbank:NM_032315.2,HGNC:HGNC:29681,MIM:610816 solute carrier family 25 member 33 GO:0000002,GO:0002082,GO:0005743,GO:0006390,GO:0006839,GO:0006864,GO:0007005,GO:0008284,GO:0015218,GO:0016021,GO:0030307,GO:0031930,GO:0031966,GO:0032869,GO:0034551,GO:0051881,GO:0071156,GO:1903426,GO:1990314,GO:1990519 mitochondrial genome maintenance|regulation of oxidative phosphorylation|mitochondrial inner membrane|transcription from mitochondrial promoter|mitochondrial transport|pyrimidine nucleotide transport|mitochondrion organization|positive regulation of cell proliferation|pyrimidine nucleotide transmembrane transporter activity|integral component of membrane|positive regulation of cell growth|mitochondria-nucleus signaling pathway|mitochondrial membrane|cellular response to insulin stimulus|mitochondrial respiratory chain complex III assembly|regulation of mitochondrial membrane potential|regulation of cell cycle arrest|regulation of reactive oxygen species biosynthetic process|cellular response to insulin-like growth factor stimulus|pyrimidine nucleotide import into mitochondrion SLC25A34 4.95532844942678 2.64246210852658 7.26819479032697 2.75053888828691 1.45971430056261 0.29893633340671 1 0.046211 0.0100072 0.0536697 0.0904277 GeneID:284723,Genbank:XM_011541292.2,HGNC:HGNC:27653,MIM:610817 solute carrier family 25 member 34 GO:0005743,GO:0006839,GO:0016021,GO:0022857 mitochondrial inner membrane|mitochondrial transport|integral component of membrane|transmembrane transporter activity SLC25A35 285.360752237123 283.832500623301 286.889003850945 1.01076868653495 0.0154528756077318 0.94519747527318 1 1.94306 2.05023 2.06964 1.89989 GeneID:399512,Genbank:NM_001320871.1,HGNC:HGNC:31921,MIM:610818 solute carrier family 25 member 35 GO:0005743,GO:0006839,GO:0016021,GO:0022857 mitochondrial inner membrane|mitochondrial transport|integral component of membrane|transmembrane transporter activity SLC25A36 258.904307441381 277.89380887002 239.914806012742 0.863332677285221 -0.212011499115564 0.32403891891446 1 2.38812 2.18761 2.34154 1.7708 GeneID:55186,Genbank:NM_001104647.1,HGNC:HGNC:25554,MIM:616149 solute carrier family 25 member 36 GO:0000002,GO:0005739,GO:0005743,GO:0006839,GO:0006864,GO:0007005,GO:0015218,GO:0016021,GO:0051881,GO:1990519 mitochondrial genome maintenance|mitochondrion|mitochondrial inner membrane|mitochondrial transport|pyrimidine nucleotide transport|mitochondrion organization|pyrimidine nucleotide transmembrane transporter activity|integral component of membrane|regulation of mitochondrial membrane potential|pyrimidine nucleotide import into mitochondrion SLC25A37 1180.75377775099 1263.30323098641 1098.20432451558 0.869311735756488 -0.20205447367985 0.178962894601194 1 6.84087 6.55237 6.24637 5.4616 GeneID:51312,Genbank:NM_001317814.1,HGNC:HGNC:29786,MIM:610387 solute carrier family 25 member 37 GO:0005381,GO:0005743,GO:0006839,GO:0016021,GO:0048250,GO:0055072 iron ion transmembrane transporter activity|mitochondrial inner membrane|mitochondrial transport|integral component of membrane|mitochondrial iron ion transport|iron ion homeostasis SLC25A38 1432.40187111231 1473.51240245909 1391.29133976553 0.94420063071316 -0.0828346482444981 0.562584722508958 1 13.4967 14.2939 12.3386 13.662 GeneID:54977,Genbank:NM_017875.3,HGNC:HGNC:26054,MIM:610819 solute carrier family 25 member 38 GO:0005743,GO:0006783,GO:0006839,GO:0015187,GO:0016021,GO:0030218,GO:0036233,GO:1904983 mitochondrial inner membrane|heme biosynthetic process|mitochondrial transport|glycine transmembrane transporter activity|integral component of membrane|erythrocyte differentiation|glycine import|glycine import into mitochondrion SLC25A39 3743.99239978613 3823.86499186837 3664.1198077039 0.958224156840219 -0.0615649106027344 0.62360514464573 1 66.3811 70.8293 64.156 69.5491 GeneID:51629,Genbank:NM_001321240.1,HGNC:HGNC:24279,MIM:610820 solute carrier family 25 member 39 GO:0005743,GO:0006783,GO:0006839,GO:0016021,GO:0022857 mitochondrial inner membrane|heme biosynthetic process|mitochondrial transport|integral component of membrane|transmembrane transporter activity SLC25A4 840.45439439131 884.226424596568 796.682364186051 0.900993616594913 -0.150411210091041 0.335932838806074 1 7.43344 7.86861 6.69471 7.31888 GeneID:291,Genbank:NM_001151.3,HGNC:HGNC:10990,MIM:103220 solute carrier family 25 member 4 GO:0000002,GO:0005471,GO:0005739,GO:0005743,GO:0005887,GO:0006091,GO:0006810,GO:0008637,GO:0015207,GO:0015866,GO:0016032,GO:0032592,GO:0043209,GO:0046902,GO:0050796,GO:0060546 mitochondrial genome maintenance|ATP:ADP antiporter activity|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|generation of precursor metabolites and energy|transport|apoptotic mitochondrial changes|adenine transmembrane transporter activity|ADP transport|viral process|integral component of mitochondrial membrane|myelin sheath|regulation of mitochondrial membrane permeability|regulation of insulin secretion|negative regulation of necroptotic process hsa04020,hsa04022,hsa04217,hsa04218,hsa05012,hsa05016,hsa05166 Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|Parkinson disease|Huntington disease|Human T-cell leukemia virus 1 infection SLC25A40 516.522433753092 546.908497575014 486.13636993117 0.888880630099355 -0.169938405783625 0.466694374933252 1 8.08758 7.09008 8.03664 5.60046 GeneID:55972,Genbank:NM_018843.3,HGNC:HGNC:29680,MIM:610821 solute carrier family 25 member 40 GO:0005743,GO:0006839,GO:0016021,GO:0022857 mitochondrial inner membrane|mitochondrial transport|integral component of membrane|transmembrane transporter activity SLC25A41 1.97635911008993 2.49838328447175 1.45433493570811 0.582110417063414 -0.780635259553285 0.825705092174523 1 0.0277335 0 0.0515918 0.0240945 GeneID:284427,Genbank:XM_011527926.1,HGNC:HGNC:28533,MIM:610822 solute carrier family 25 member 41 GO:0005347,GO:0005743,GO:0006839,GO:0015217,GO:0016021 ATP transmembrane transporter activity|mitochondrial inner membrane|mitochondrial transport|ADP transmembrane transporter activity|integral component of membrane SLC25A42 283.874258015902 254.707582499716 313.040933532089 1.22902086565263 0.297509409215894 0.14569213656022 1 3.00056 2.97692 3.43775 4.2626 GeneID:284439,Genbank:NM_001321544.1,HGNC:HGNC:28380,MIM:610823 solute carrier family 25 member 42 GO:0005347,GO:0005634,GO:0005739,GO:0005743,GO:0006839,GO:0015217,GO:0015228,GO:0015866,GO:0015867,GO:0016021,GO:0035349,GO:0043262,GO:0080121,GO:0080122 ATP transmembrane transporter activity|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial transport|ADP transmembrane transporter activity|coenzyme A transmembrane transporter activity|ADP transport|ATP transport|integral component of membrane|coenzyme A transmembrane transport|adenosine-diphosphatase activity|AMP transport|AMP transmembrane transporter activity SLC25A43 590.963000191913 630.363697730965 551.56230265286 0.874990588192569 -0.192660596160606 0.260638743205341 1 6.93033 6.41547 6.63286 5.11841 GeneID:203427,Genbank:NM_145305.2,HGNC:HGNC:30557,MIM:300641 solute carrier family 25 member 43 GO:0005743,GO:0006839,GO:0016021,GO:0022857 mitochondrial inner membrane|mitochondrial transport|integral component of membrane|transmembrane transporter activity SLC25A44 1354.36364941254 1238.27238886786 1470.45490995722 1.18750520739757 0.247933839902688 0.0915289706971386 0.983401187832981 5.56509 5.5114 7.43927 6.21357 GeneID:9673,Genbank:NM_001286184.1,HGNC:HGNC:29036,MIM:610824 solute carrier family 25 member 44 GO:0005743,GO:0006839,GO:0022857,GO:0031307 mitochondrial inner membrane|mitochondrial transport|transmembrane transporter activity|integral component of mitochondrial outer membrane SLC25A45 40.3408847764178 42.404872251119 38.2768973017166 0.902653286514889 -0.147756146913509 0.755119482286317 1 0.340934 0.479431 0.291389 0.534571 GeneID:283130,Genbank:NM_001278251.2,HGNC:HGNC:27442,MIM:610825 solute carrier family 25 member 45 GO:0005743,GO:0006839,GO:0016021,GO:0022857 mitochondrial inner membrane|mitochondrial transport|integral component of membrane|transmembrane transporter activity SLC25A46 673.871036164219 689.545650507366 658.196421821072 0.954536398477422 -0.0671278832176416 0.738745864019822 1 6.97698 6.54092 7.43951 5.5659 GeneID:91137,Genbank:NM_001303250.2,HGNC:HGNC:25198,MIM:610826 solute carrier family 25 member 46 GO:0005739,GO:0005741,GO:0016021,GO:0090149 mitochondrion|mitochondrial outer membrane|integral component of membrane|mitochondrial membrane fission SLC25A47 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0669662 0 GeneID:283600,Genbank:NM_001350877.1,HGNC:HGNC:20115,MIM:609911 solute carrier family 25 member 47 GO:0005743,GO:0006839,GO:0016021,GO:0022857 mitochondrial inner membrane|mitochondrial transport|integral component of membrane|transmembrane transporter activity SLC25A48 13.8436034754828 10.7237359132691 16.9634710376966 1.58186206513224 0.661623805483573 0.411895201859703 1 0.101431 0.0686009 0.119244 0.122577 GeneID:153328,Genbank:NM_001349335.1,HGNC:HGNC:30451,MIM:616150 solute carrier family 25 member 48 GO:0005743,GO:0006839,GO:0016021,GO:0022857 mitochondrial inner membrane|mitochondrial transport|integral component of membrane|transmembrane transporter activity SLC25A5 17526.1392332563 18515.4274456123 16536.8510209003 0.893139036053915 -0.163043315944118 0.426899006463132 1 722.377 760.67 593.781 743.692 GeneID:292,Genbank:NM_001152.4,HGNC:HGNC:10991,MIM:300150 solute carrier family 25 member 5 GO:0003723,GO:0005471,GO:0005634,GO:0005739,GO:0005743,GO:0005887,GO:0006810,GO:0007059,GO:0008284,GO:0015207,GO:0016020,GO:0016032,GO:0031012,GO:0031625,GO:0042645,GO:0043209,GO:0045121,GO:0050796,GO:0070062,GO:0071817,GO:1901029,GO:1990830 RNA binding|ATP:ADP antiporter activity|nucleus|mitochondrion|mitochondrial inner membrane|integral component of plasma membrane|transport|chromosome segregation|positive regulation of cell proliferation|adenine transmembrane transporter activity|membrane|viral process|extracellular matrix|ubiquitin protein ligase binding|mitochondrial nucleoid|myelin sheath|membrane raft|regulation of insulin secretion|extracellular exosome|MMXD complex|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|cellular response to leukemia inhibitory factor hsa04020,hsa04022,hsa04217,hsa04218,hsa05012,hsa05016,hsa05166 Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|Parkinson disease|Huntington disease|Human T-cell leukemia virus 1 infection SLC25A51 179.20852947162 188.299020207794 170.118038735446 0.903446223712241 -0.146489365510404 0.555396332263517 1 3.80844 3.78822 3.93607 3.15512 GeneID:92014,Genbank:NM_033412.3,HGNC:HGNC:23323 solute carrier family 25 member 51 GO:0005743,GO:0006839,GO:0016021,GO:0022857 mitochondrial inner membrane|mitochondrial transport|integral component of membrane|transmembrane transporter activity SLC25A53 74.1854684226094 73.7400160110663 74.6309208341524 1.01208170097159 0.0173257572544291 0.987716943214918 1 0.273155 0.295122 0.266509 0.253853 GeneID:401612,Genbank:NM_001012755.4,HGNC:HGNC:31894,MIM:300941 solute carrier family 25 member 53 GO:0005743,GO:0006839,GO:0016021,GO:0022857 mitochondrial inner membrane|mitochondrial transport|integral component of membrane|transmembrane transporter activity SLC25A6 36.3290458576827 34.3716247210614 38.2864669943039 1.11389750426443 0.155616488609389 0.766273100407605 1 1.024 0.906451 1.21159 1.00346 GeneID:293,Genbank:NM_001636.3,HGNC:HGNC:10992,MIM:403000 solute carrier family 25 member 6 GO:0005471,GO:0005634,GO:0005739,GO:0005743,GO:0005744,GO:0006626,GO:0006915,GO:0015207,GO:0016021,GO:0031012,GO:0046732,GO:0046902,GO:0050796 ATP:ADP antiporter activity|nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial inner membrane presequence translocase complex|protein targeting to mitochondrion|apoptotic process|adenine transmembrane transporter activity|integral component of membrane|extracellular matrix|active induction of host immune response by virus|regulation of mitochondrial membrane permeability|regulation of insulin secretion hsa04020,hsa04022,hsa04217,hsa04218,hsa05012,hsa05016,hsa05164,hsa05166 Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|Parkinson disease|Huntington disease|Influenza A|Human T-cell leukemia virus 1 infection SLC26A1 12.4688126008574 12.338028943196 12.5995962585189 1.02120008929523 0.0302655690090374 1 1 0.0869634 0.110091 0.106102 0.124171 GeneID:10861,Genbank:NM_134425.2,HGNC:HGNC:10993,MIM:610130 solute carrier family 26 member 1 GO:0005254,GO:0005886,GO:0005887,GO:0006811,GO:0006821,GO:0008271,GO:0008272,GO:0015106,GO:0015108,GO:0015116,GO:0015301,GO:0015701,GO:0016021,GO:0016323,GO:0019531,GO:0019532,GO:0042391,GO:0050428,GO:0051453,GO:1902476 chloride channel activity|plasma membrane|integral component of plasma membrane|ion transport|chloride transport|secondary active sulfate transmembrane transporter activity|sulfate transport|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|integral component of membrane|basolateral plasma membrane|oxalate transmembrane transporter activity|oxalate transport|regulation of membrane potential|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|regulation of intracellular pH|chloride transmembrane transport SLC26A10 42.7441248273608 34.6117560944861 50.8764935602354 1.46991945226207 0.555737101316133 0.197854889645159 1 0.0640033 0.0377412 0.0798253 0.186109 GeneID:65012,Genbank:NM_133489.2,HGNC:HGNC:14470 solute carrier family 26 member 10 GO:0005254,GO:0005887,GO:0008271,GO:0015106,GO:0015116,GO:0015301,GO:0015701,GO:0019531,GO:0042391,GO:0051453,GO:1902476 chloride channel activity|integral component of plasma membrane|secondary active sulfate transmembrane transporter activity|bicarbonate transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|oxalate transmembrane transporter activity|regulation of membrane potential|regulation of intracellular pH|chloride transmembrane transport SLC26A11 151.534192024397 175.634615996911 127.433768051882 0.725561799583536 -0.462829594095572 0.0892712830175256 0.978485089907035 1.92026 2.01067 1.3199 1.7022 GeneID:284129,Genbank:XM_017024505.1,HGNC:HGNC:14471,MIM:610117 solute carrier family 26 member 11 GO:0005254,GO:0005654,GO:0005765,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0006811,GO:0008271,GO:0008272,GO:0008509,GO:0015106,GO:0015116,GO:0015301,GO:0015701,GO:0016021,GO:0019531,GO:0042391,GO:0043231,GO:0051453,GO:0070062,GO:1902476 chloride channel activity|nucleoplasm|lysosomal membrane|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|ion transport|secondary active sulfate transmembrane transporter activity|sulfate transport|anion transmembrane transporter activity|bicarbonate transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|integral component of membrane|oxalate transmembrane transporter activity|regulation of membrane potential|intracellular membrane-bounded organelle|regulation of intracellular pH|extracellular exosome|chloride transmembrane transport SLC26A2 302.647508216026 289.241886354193 316.053130077859 1.09269488614396 0.127890612631015 0.749554435943057 1 1.76449 1.52055 2.34496 1.30879 GeneID:1836,Genbank:NM_000112.3,HGNC:HGNC:10994,MIM:606718 solute carrier family 26 member 2 GO:0001503,GO:0005254,GO:0005886,GO:0005887,GO:0006811,GO:0008271,GO:0015106,GO:0015116,GO:0015301,GO:0015701,GO:0016020,GO:0016324,GO:0019531,GO:0031528,GO:0042391,GO:0050428,GO:0051453,GO:0070062,GO:1902358,GO:1902476 ossification|chloride channel activity|plasma membrane|integral component of plasma membrane|ion transport|secondary active sulfate transmembrane transporter activity|bicarbonate transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|membrane|apical plasma membrane|oxalate transmembrane transporter activity|microvillus membrane|regulation of membrane potential|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|regulation of intracellular pH|extracellular exosome|sulfate transmembrane transport|chloride transmembrane transport SLC26A4 15.3252276099916 16.5947840816495 14.0556711383338 0.846993312427399 -0.239577516316803 0.798547788999505 1 0.137259 0.085072 0.116754 0.0722497 GeneID:5172,Genbank:NM_000441.1,HGNC:HGNC:8818,MIM:605646 solute carrier family 26 member 4 hsa04918 Thyroid hormone synthesis SLC26A5 8.77657436579352 10.771762187954 6.78138654363301 0.629552196317199 -0.667602097806964 0.525918600104028 1 0.0486327 0.0413929 0.0155933 0.0532309 GeneID:375611,Genbank:NM_206885.2,HGNC:HGNC:9359,MIM:604943 solute carrier family 26 member 5 SLC26A6 1019.28181495541 1081.40456496939 957.159064941438 0.885107290968884 -0.176075748429802 0.24431642671174 1 10.4989 9.83563 9.41528 8.25257 GeneID:65010,Genbank:NM_001281733.1,HGNC:HGNC:14472,MIM:610068 solute carrier family 26 member 6 GO:0005254,GO:0005452,GO:0005622,GO:0005783,GO:0005886,GO:0005887,GO:0006811,GO:0006821,GO:0008271,GO:0008272,GO:0012506,GO:0015106,GO:0015108,GO:0015116,GO:0015301,GO:0015499,GO:0015562,GO:0015660,GO:0015701,GO:0015724,GO:0015797,GO:0016020,GO:0016021,GO:0016323,GO:0016324,GO:0019531,GO:0019532,GO:0030165,GO:0030321,GO:0030659,GO:0031526,GO:0031982,GO:0034707,GO:0038166,GO:0042045,GO:0042391,GO:0046724,GO:0048240,GO:0050892,GO:0051453,GO:0051454,GO:0070528,GO:0070633,GO:0071320,GO:0071332,GO:0071346,GO:0097225,GO:2001150 chloride channel activity|inorganic anion exchanger activity|intracellular|endoplasmic reticulum|plasma membrane|integral component of plasma membrane|ion transport|chloride transport|secondary active sulfate transmembrane transporter activity|sulfate transport|vesicle membrane|bicarbonate transmembrane transporter activity|chloride transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|formate transmembrane transporter activity|efflux transmembrane transporter activity|formate efflux transmembrane transporter activity|bicarbonate transport|formate transport|mannitol transport|membrane|integral component of membrane|basolateral plasma membrane|apical plasma membrane|oxalate transmembrane transporter activity|oxalate transport|PDZ domain binding|transepithelial chloride transport|cytoplasmic vesicle membrane|brush border membrane|vesicle|chloride channel complex|angiotensin-activated signaling pathway|epithelial fluid transport|regulation of membrane potential|oxalic acid secretion|sperm capacitation|intestinal absorption|regulation of intracellular pH|intracellular pH elevation|protein kinase C signaling|transepithelial transport|cellular response to cAMP|cellular response to fructose stimulus|cellular response to interferon-gamma|sperm midpiece|positive regulation of dipeptide transmembrane transport hsa04978 Mineral absorption SLC26A7 1.45346496365472 0 2.90692992730943 Inf Inf 0.254687062456722 1 0 0 0.0154205 0.0143303 GeneID:115111,Genbank:NM_001282356.1,HGNC:HGNC:14467,MIM:608479 solute carrier family 26 member 7 GO:0001696,GO:0005254,GO:0005737,GO:0005768,GO:0005886,GO:0005887,GO:0006811,GO:0006820,GO:0006821,GO:0008271,GO:0008272,GO:0015106,GO:0015116,GO:0015301,GO:0015701,GO:0016323,GO:0019531,GO:0019532,GO:0042391,GO:0051453,GO:0055038 gastric acid secretion|chloride channel activity|cytoplasm|endosome|plasma membrane|integral component of plasma membrane|ion transport|anion transport|chloride transport|secondary active sulfate transmembrane transporter activity|sulfate transport|bicarbonate transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|basolateral plasma membrane|oxalate transmembrane transporter activity|oxalate transport|regulation of membrane potential|regulation of intracellular pH|recycling endosome membrane hsa04971 Gastric acid secretion SLC26A9 11.4497797489447 12.2419763938261 10.6575831040634 0.870577001719937 -0.199956186343042 0.855655829142903 1 0.0657643 0.0814558 0.0309089 0.0794516 GeneID:115019,Genbank:XM_011509121.2,HGNC:HGNC:14469,MIM:608481 solute carrier family 26 member 9 GO:0005254,GO:0005886,GO:0005887,GO:0006811,GO:0006820,GO:0006821,GO:0008271,GO:0009986,GO:0010628,GO:0015106,GO:0015116,GO:0015301,GO:0015701,GO:0016324,GO:0019531,GO:0042391,GO:0051117,GO:0051453,GO:0070062 chloride channel activity|plasma membrane|integral component of plasma membrane|ion transport|anion transport|chloride transport|secondary active sulfate transmembrane transporter activity|cell surface|positive regulation of gene expression|bicarbonate transmembrane transporter activity|sulfate transmembrane transporter activity|anion:anion antiporter activity|bicarbonate transport|apical plasma membrane|oxalate transmembrane transporter activity|regulation of membrane potential|ATPase binding|regulation of intracellular pH|extracellular exosome hsa04978 Mineral absorption SLC27A1 318.781821362818 261.472529577749 376.091113147887 1.43835803231504 0.524422832351081 0.00806941786819647 0.354081634457629 2.75804 2.89856 4.34966 3.86905 GeneID:376497,Genbank:XM_011528003.2,HGNC:HGNC:10995,MIM:600691 solute carrier family 27 member 1 GO:0000166,GO:0001579,GO:0004467,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0006646,GO:0006654,GO:0006655,GO:0006656,GO:0006659,GO:0006661,GO:0009409,GO:0015245,GO:0015909,GO:0016020,GO:0016021,GO:0019216,GO:0031652,GO:0031957,GO:0032049,GO:0032868,GO:0033211,GO:0042803,GO:0071072,GO:0071902 nucleotide binding|medium-chain fatty acid transport|long-chain fatty acid-CoA ligase activity|mitochondrion|endoplasmic reticulum|cytosol|plasma membrane|phosphatidylethanolamine biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylglycerol biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylserine biosynthetic process|phosphatidylinositol biosynthetic process|response to cold|fatty acid transmembrane transporter activity|long-chain fatty acid transport|membrane|integral component of membrane|regulation of lipid metabolic process|positive regulation of heat generation|very long-chain fatty acid-CoA ligase activity|cardiolipin biosynthetic process|response to insulin|adiponectin-activated signaling pathway|protein homodimerization activity|negative regulation of phospholipid biosynthetic process|positive regulation of protein serine/threonine kinase activity hsa03320,hsa04931 PPAR signaling pathway|Insulin resistance SLC27A2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0173119 0 0 GeneID:11001,Genbank:NM_003645.3,HGNC:HGNC:10996,MIM:603247 solute carrier family 27 member 2 GO:0001561,GO:0001676,GO:0004467,GO:0005102,GO:0005524,GO:0005739,GO:0005778,GO:0005779,GO:0005788,GO:0005789,GO:0005886,GO:0006635,GO:0006699,GO:0015245,GO:0019899,GO:0030176,GO:0031957,GO:0035579,GO:0042760,GO:0043312,GO:0044539,GO:0050197,GO:0070062,GO:0070251,GO:0097089,GO:0102391 fatty acid alpha-oxidation|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|receptor binding|ATP binding|mitochondrion|peroxisomal membrane|integral component of peroxisomal membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|plasma membrane|fatty acid beta-oxidation|bile acid biosynthetic process|fatty acid transmembrane transporter activity|enzyme binding|integral component of endoplasmic reticulum membrane|very long-chain fatty acid-CoA ligase activity|specific granule membrane|very long-chain fatty acid catabolic process|neutrophil degranulation|long-chain fatty acid import|phytanate-CoA ligase activity|extracellular exosome|pristanate-CoA ligase activity|methyl-branched fatty acid metabolic process|decanoate--CoA ligase activity hsa03320,hsa04146,hsa04931 PPAR signaling pathway|Peroxisome|Insulin resistance SLC27A3 564.199450075487 468.442289334607 659.956610816367 1.40883226352982 0.494499853678051 0.136319249234855 1 6.04243 6.49771 7.71785 10.5668 GeneID:11000,Genbank:NM_024330.2,HGNC:HGNC:10997,MIM:604193 solute carrier family 27 member 3 GO:0000166,GO:0004467,GO:0005783,GO:0016020,GO:0016021,GO:0031957,GO:0031966 nucleotide binding|long-chain fatty acid-CoA ligase activity|endoplasmic reticulum|membrane|integral component of membrane|very long-chain fatty acid-CoA ligase activity|mitochondrial membrane hsa04931 Insulin resistance SLC27A4 1120.28850143731 1055.65332873057 1184.92367414406 1.12245530032946 0.166657993494655 0.282366618266405 1 12.5993 14.0391 15.612 14.9626 GeneID:10999,Genbank:XM_024447391.1,HGNC:HGNC:10998,MIM:604194 solute carrier family 27 member 4 GO:0000166,GO:0001579,GO:0001676,GO:0004467,GO:0005789,GO:0005886,GO:0005902,GO:0006629,GO:0006810,GO:0007584,GO:0015245,GO:0015908,GO:0015909,GO:0016020,GO:0016021,GO:0031526,GO:0031957,GO:0042760,GO:0043588,GO:0044539 nucleotide binding|medium-chain fatty acid transport|long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|endoplasmic reticulum membrane|plasma membrane|microvillus|lipid metabolic process|transport|response to nutrient|fatty acid transmembrane transporter activity|fatty acid transport|long-chain fatty acid transport|membrane|integral component of membrane|brush border membrane|very long-chain fatty acid-CoA ligase activity|very long-chain fatty acid catabolic process|skin development|long-chain fatty acid import hsa03320,hsa04931,hsa04975 PPAR signaling pathway|Insulin resistance|Fat digestion and absorption SLC27A5 129.961011078868 135.382134452361 124.539887705374 0.919913755305706 -0.120429484397254 0.662307882264563 1 1.96692 1.90343 1.6167 1.92427 GeneID:10998,Genbank:NM_001321196.1,HGNC:HGNC:10999,MIM:603314 solute carrier family 27 member 5 GO:0000038,GO:0004467,GO:0005524,GO:0005783,GO:0005789,GO:0006642,GO:0006699,GO:0009925,GO:0015245,GO:0015721,GO:0015911,GO:0030176,GO:0031957,GO:0032403,GO:0043234,GO:0046951,GO:0047747 very long-chain fatty acid metabolic process|long-chain fatty acid-CoA ligase activity|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|triglyceride mobilization|bile acid biosynthetic process|basal plasma membrane|fatty acid transmembrane transporter activity|bile acid and bile salt transport|plasma membrane long-chain fatty acid transport|integral component of endoplasmic reticulum membrane|very long-chain fatty acid-CoA ligase activity|protein complex binding|protein complex|ketone body biosynthetic process|cholate-CoA ligase activity hsa00120,hsa03320,hsa04931,hsa04976 Primary bile acid biosynthesis|PPAR signaling pathway|Insulin resistance|Bile secretion SLC27A6 72.3206583960092 66.6192677000227 78.0220490919956 1.17116341541486 0.227942392798875 0.570523209987533 1 1.06228 0.544179 0.854834 1.01108 GeneID:28965,Genbank:NM_001017372.2,HGNC:HGNC:11000,MIM:604196 solute carrier family 27 member 6 GO:0000038,GO:0000166,GO:0004467,GO:0005886,GO:0015245,GO:0015909,GO:0016021,GO:0031957,GO:0042383 very long-chain fatty acid metabolic process|nucleotide binding|long-chain fatty acid-CoA ligase activity|plasma membrane|fatty acid transmembrane transporter activity|long-chain fatty acid transport|integral component of membrane|very long-chain fatty acid-CoA ligase activity|sarcolemma hsa03320,hsa04931 PPAR signaling pathway|Insulin resistance SLC28A1 1.0016543915721 1.51824048055703 0.48506830258717 0.319493722370782 -1.64614051048666 0.791481013618379 1 0.00795625 0 0.00749104 0 GeneID:9154,Genbank:XM_011522208.3,HGNC:HGNC:11001,MIM:606207 solute carrier family 28 member 1 GO:0005337,GO:0005415,GO:0005886,GO:0005887,GO:0006139,GO:0015389,GO:0015858,GO:0016020 nucleoside transmembrane transporter activity|nucleoside:sodium symporter activity|plasma membrane|integral component of plasma membrane|nucleobase-containing compound metabolic process|pyrimidine- and adenine-specific:sodium symporter activity|nucleoside transport|membrane SLC28A2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:9153,Genbank:NM_004212.3,HGNC:HGNC:11002,MIM:606208 solute carrier family 28 member 2 GO:0005415,GO:0005886,GO:0005887,GO:0006139,GO:0015211,GO:0015860,GO:0016020 nucleoside:sodium symporter activity|plasma membrane|integral component of plasma membrane|nucleobase-containing compound metabolic process|purine nucleoside transmembrane transporter activity|purine nucleoside transmembrane transport|membrane SLC28A3 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.00944219 0 0 GeneID:64078,Genbank:XM_011518907.2,HGNC:HGNC:16484,MIM:608269 solute carrier family 28 member 3 GO:0005415,GO:0005789,GO:0005886,GO:0005887,GO:0015389,GO:0015390,GO:0015864 nucleoside:sodium symporter activity|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|pyrimidine- and adenine-specific:sodium symporter activity|purine-specific nucleoside:sodium symporter activity|pyrimidine nucleoside transport SLC29A1 1258.8266473282 1347.78761722182 1169.86567743457 0.867989631664675 -0.204250285437995 0.161981946750873 1 21.8582 21.9429 19.095 19.2839 GeneID:2030,Genbank:NM_001304462.1,HGNC:HGNC:11003,MIM:602193 solute carrier family 29 member 1 (Augustine blood group) GO:0005337,GO:0005886,GO:0005887,GO:0006139,GO:0007595,GO:0015858,GO:0015862,GO:0016020,GO:0016323,GO:0016324,GO:0030431,GO:0060079,GO:0071333,GO:0071456,GO:0098794 nucleoside transmembrane transporter activity|plasma membrane|integral component of plasma membrane|nucleobase-containing compound metabolic process|lactation|nucleoside transport|uridine transport|membrane|basolateral plasma membrane|apical plasma membrane|sleep|excitatory postsynaptic potential|cellular response to glucose stimulus|cellular response to hypoxia|postsynapse hsa05034 Alcoholism SLC29A2 102.165265436037 85.587973552305 118.742557319769 1.38737432832433 0.472357094623403 0.11144333961314 1 0.685324 0.603008 1.08237 0.895537 GeneID:3177,Genbank:NM_001300869.1,HGNC:HGNC:11004,MIM:602110 solute carrier family 29 member 2 GO:0005337,GO:0005730,GO:0005886,GO:0005887,GO:0006139,GO:0008283,GO:0015858,GO:0016323,GO:0031965 nucleoside transmembrane transporter activity|nucleolus|plasma membrane|integral component of plasma membrane|nucleobase-containing compound metabolic process|cell proliferation|nucleoside transport|basolateral plasma membrane|nuclear membrane SLC29A3 36.805110321038 37.2640268581206 36.3461937839553 0.975369460803044 -0.0359792931489548 0.958335568023021 1 0.483981 0.603779 0.571102 0.53266 GeneID:55315,Genbank:NM_001174098.1,HGNC:HGNC:23096,MIM:612373 solute carrier family 29 member 3 GO:0005337,GO:0005765,GO:0005794,GO:0016021,GO:0031902,GO:0043231 nucleoside transmembrane transporter activity|lysosomal membrane|Golgi apparatus|integral component of membrane|late endosome membrane|intracellular membrane-bounded organelle SLC29A4 184.511441566587 173.251902572025 195.770980561149 1.12997882075068 0.176295732388863 0.539673090533809 1 2.431 2.79985 2.80492 3.351 GeneID:222962,Genbank:XM_011515200.2,HGNC:HGNC:23097,MIM:609149 solute carrier family 29 member 4 GO:0005337,GO:0005886,GO:0008504,GO:0016021,GO:0016324 nucleoside transmembrane transporter activity|plasma membrane|monoamine transmembrane transporter activity|integral component of membrane|apical plasma membrane SLC2A1 12272.997627158 12725.8151386709 11820.1801156451 0.92883481229632 -0.106506050132123 0.397201866758971 1 145.747 155.183 140.088 143.199 GeneID:6513,Genbank:NM_006516.2,HGNC:HGNC:11005,MIM:138140 solute carrier family 2 member 1 hsa04066,hsa04911,hsa04919,hsa04920,hsa04922,hsa04931,hsa04976,hsa05166,hsa05200,hsa05211,hsa05230 HIF-1 signaling pathway|Insulin secretion|Thyroid hormone signaling pathway|Adipocytokine signaling pathway|Glucagon signaling pathway|Insulin resistance|Bile secretion|Human T-cell leukemia virus 1 infection|Pathways in cancer|Renal cell carcinoma|Central carbon metabolism in cancer SLC2A10 175.622433163955 151.582899681423 199.661966646487 1.31718001876274 0.397452531948298 0.0945079451468814 0.994506734213175 0.969451 0.860128 1.16542 1.20189 GeneID:81031,Genbank:XM_011529064.2,HGNC:HGNC:13444,MIM:606145 solute carrier family 2 member 10 GO:0005351,GO:0005355,GO:0005886,GO:0008645,GO:0012505,GO:0015758,GO:0016021,GO:0035428,GO:0046323,GO:0048471,GO:0055056 sugar:proton symporter activity|glucose transmembrane transporter activity|plasma membrane|hexose transport|endomembrane system|glucose transport|integral component of membrane|hexose transmembrane transport|glucose import|perinuclear region of cytoplasm|D-glucose transmembrane transporter activity SLC2A11 156.042335653267 136.170172157536 175.914499148997 1.2918724883852 0.369463678814541 0.142789701633645 1 1.10796 1.37966 1.56587 1.66861 GeneID:66035,Genbank:NM_030807.4,HGNC:HGNC:14239,MIM:610367 solute carrier family 2 member 11 GO:0005634,GO:0005886,GO:0008645,GO:0016021,GO:0030054,GO:0051119 nucleus|plasma membrane|hexose transport|integral component of membrane|cell junction|sugar transmembrane transporter activity SLC2A12 392.181595971096 378.183924481045 406.179267461146 1.07402573501377 0.103028562533681 0.664398579655621 1 1.68001 1.81435 2.2123 1.46782 GeneID:154091,Genbank:NM_145176.2,HGNC:HGNC:18067,MIM:610372 solute carrier family 2 member 12 GO:0005351,GO:0005355,GO:0005886,GO:0008645,GO:0012505,GO:0016021,GO:0035428,GO:0046323,GO:0048471,GO:0055056 sugar:proton symporter activity|glucose transmembrane transporter activity|plasma membrane|hexose transport|endomembrane system|integral component of membrane|hexose transmembrane transport|glucose import|perinuclear region of cytoplasm|D-glucose transmembrane transporter activity SLC2A13 55.657278758294 52.1866829800503 59.1278745365377 1.13300695043486 0.180156711403045 0.636856724986509 1 0.156755 0.118079 0.207493 0.144829 GeneID:114134,Genbank:XM_011537847.2,HGNC:HGNC:15956,MIM:611036 solute carrier family 2 member 13 GO:0005351,GO:0005355,GO:0005366,GO:0005886,GO:0015798,GO:0016021,GO:0035428,GO:0046323 sugar:proton symporter activity|glucose transmembrane transporter activity|myo-inositol:proton symporter activity|plasma membrane|myo-inositol transport|integral component of membrane|hexose transmembrane transport|glucose import SLC2A14 6.52409675435384 6.26506702096788 6.78312648773981 1.08269017155572 0.114620452632087 0.978321861858245 1 0.126009 0.0537517 0.0922067 0.0772177 GeneID:144195,Genbank:NM_001286237.1,HGNC:HGNC:18301,MIM:611039 solute carrier family 2 member 14 GO:0005634,GO:0005886,GO:0007275,GO:0007283,GO:0015758,GO:0016021,GO:0030154,GO:0055056 nucleus|plasma membrane|multicellular organism development|spermatogenesis|glucose transport|integral component of membrane|cell differentiation|D-glucose transmembrane transporter activity SLC2A2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0131777 GeneID:6514,Genbank:XM_024453720.1,HGNC:HGNC:11006,MIM:138160 solute carrier family 2 member 2 hsa04911,hsa04917,hsa04922,hsa04930,hsa04931,hsa04950,hsa04973,hsa05230 Insulin secretion|Prolactin signaling pathway|Glucagon signaling pathway|Type II diabetes mellitus|Insulin resistance|Maturity onset diabetes of the young|Carbohydrate digestion and absorption|Central carbon metabolism in cancer SLC2A3 582.261284453463 491.340358056802 673.182210850124 1.37009345927228 0.454274308244046 0.00711430090712376 0.336294996163986 5.82541 5.97618 8.96863 7.43591 GeneID:6515,Genbank:NM_006931.2,HGNC:HGNC:11007,MIM:138170 solute carrier family 2 member 3 GO:0005355,GO:0005536,GO:0005886,GO:0005887,GO:0005975,GO:0015758,GO:0016021,GO:0019852,GO:0030667,GO:0033300,GO:0035579,GO:0043312,GO:0055056,GO:0070062,GO:0070821,GO:0101003,GO:1904659 glucose transmembrane transporter activity|glucose binding|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|glucose transport|integral component of membrane|L-ascorbic acid metabolic process|secretory granule membrane|dehydroascorbic acid transmembrane transporter activity|specific granule membrane|neutrophil degranulation|D-glucose transmembrane transporter activity|extracellular exosome|tertiary granule membrane|ficolin-1-rich granule membrane|glucose transmembrane transport SLC2A4 2.75699093802582 3.57457863775636 1.93940323829528 0.542554363697697 -0.882160392707934 0.716586129447155 1 0.0348745 0.0619874 0.048861 0.0152402 GeneID:6517,Genbank:NM_001042.2,HGNC:HGNC:11009,MIM:138190 solute carrier family 2 member 4 hsa04068,hsa04152,hsa04910,hsa04920,hsa04930,hsa04931 FoxO signaling pathway|AMPK signaling pathway|Insulin signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance SLC2A4RG 1954.78087186666 1803.41059786552 2106.1511458678 1.16787111507529 0.223881068822809 0.113630752389181 1 37.9327 36.0387 43.8116 43.8903 GeneID:56731,Genbank:NM_020062.3,HGNC:HGNC:15930,MIM:609493 SLC2A4 regulator GO:0001158,GO:0003700,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0006357,GO:0016607,GO:0046872 enhancer sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|nuclear speck|metal ion binding SLC2A5 1.24081702112719 1.02816907859967 1.45346496365472 1.41364391704357 0.499418765260228 1 1 0.0173986 0 0.0163171 0.0152077 GeneID:6518,Genbank:NM_001328619.1,HGNC:HGNC:11010,MIM:138230 solute carrier family 2 member 5 GO:0003044,GO:0005353,GO:0005355,GO:0005886,GO:0005887,GO:0005975,GO:0009750,GO:0015755,GO:0015758,GO:0016324,GO:0035579,GO:0042383,GO:0043312,GO:0070061,GO:0070062,GO:0071332,GO:0106001,GO:1990539 regulation of systemic arterial blood pressure mediated by a chemical signal|fructose transmembrane transporter activity|glucose transmembrane transporter activity|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|response to fructose|fructose transport|glucose transport|apical plasma membrane|specific granule membrane|sarcolemma|neutrophil degranulation|fructose binding|extracellular exosome|cellular response to fructose stimulus|intestinal hexose absorption|fructose import across plasma membrane hsa04973 Carbohydrate digestion and absorption SLC2A6 347.592105597003 384.584278671815 310.599932522192 0.807625141607107 -0.308242271999905 0.256381184391062 1 5.52975 5.86612 4.2793 5.33604 GeneID:11182,Genbank:NM_001145099.1,HGNC:HGNC:11011,MIM:606813 solute carrier family 2 member 6 GO:0005351,GO:0005355,GO:0005886,GO:0008645,GO:0016020,GO:0016021,GO:0035428,GO:0046323,GO:0055056 sugar:proton symporter activity|glucose transmembrane transporter activity|plasma membrane|hexose transport|membrane|integral component of membrane|hexose transmembrane transport|glucose import|D-glucose transmembrane transporter activity SLC2A7 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:155184,Genbank:XM_011540824.2,HGNC:HGNC:13445,MIM:610371 solute carrier family 2 member 7 GO:0005886,GO:0008645,GO:0016021,GO:0051119 plasma membrane|hexose transport|integral component of membrane|sugar transmembrane transporter activity SLC2A8 384.639563642051 366.577115314086 402.702011970016 1.09854651353503 0.135595956175074 0.561845988145419 1 7.64918 9.92863 10.3212 10.1491 GeneID:29988,Genbank:NM_014580.4,HGNC:HGNC:13812,MIM:605245 solute carrier family 2 member 8 GO:0001666,GO:0005351,GO:0005355,GO:0005536,GO:0005765,GO:0005886,GO:0005887,GO:0005975,GO:0007141,GO:0008021,GO:0008286,GO:0008645,GO:0015758,GO:0030665,GO:0046323,GO:0055056,GO:0061024 response to hypoxia|sugar:proton symporter activity|glucose transmembrane transporter activity|glucose binding|lysosomal membrane|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|male meiosis I|synaptic vesicle|insulin receptor signaling pathway|hexose transport|glucose transport|clathrin-coated vesicle membrane|glucose import|D-glucose transmembrane transporter activity|membrane organization SLC2A9 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:56606,Genbank:XM_011513857.1,HGNC:HGNC:13446,MIM:606142 solute carrier family 2 member 9 GO:0008643,GO:0016021,GO:0022857 carbohydrate transport|integral component of membrane|transmembrane transporter activity SLC30A1 187.343622484999 192.930176888619 181.757068081378 0.942087292991542 -0.0860673499843282 0.823226159440443 1 4.95148 3.41009 4.84046 3.42514 GeneID:7779,Genbank:NM_021194.2,HGNC:HGNC:11012,MIM:609521 solute carrier family 30 member 1 GO:0001701,GO:0005385,GO:0005737,GO:0005783,GO:0005794,GO:0005886,GO:0006829,GO:0006874,GO:0006882,GO:0010043,GO:0016021,GO:0019855,GO:0030315,GO:0031965,GO:0046929,GO:0061088,GO:0070509,GO:0070574,GO:0071584,GO:0071585,GO:0090281 in utero embryonic development|zinc ion transmembrane transporter activity|cytoplasm|endoplasmic reticulum|Golgi apparatus|plasma membrane|zinc II ion transport|cellular calcium ion homeostasis|cellular zinc ion homeostasis|response to zinc ion|integral component of membrane|calcium channel inhibitor activity|T-tubule|nuclear membrane|negative regulation of neurotransmitter secretion|regulation of sequestering of zinc ion|calcium ion import|cadmium ion transmembrane transport|negative regulation of zinc ion transmembrane import|detoxification of cadmium ion|negative regulation of calcium ion import hsa04978 Mineral absorption SLC30A3 39.082807256084 40.8484141509849 37.317200361183 0.913553221999028 -0.130439314718346 0.805856476240847 1 0.499718 0.905342 0.598768 0.65395 GeneID:7781,Genbank:XM_011533102.2,HGNC:HGNC:11014,MIM:602878 solute carrier family 30 member 3 GO:0005737,GO:0005765,GO:0005768,GO:0005770,GO:0005887,GO:0006810,GO:0008021,GO:0010043,GO:0015633,GO:0016020,GO:0030054,GO:0030672,GO:0031902,GO:0043005,GO:0051050,GO:0061088 cytoplasm|lysosomal membrane|endosome|late endosome|integral component of plasma membrane|transport|synaptic vesicle|response to zinc ion|zinc-transporting ATPase activity|membrane|cell junction|synaptic vesicle membrane|late endosome membrane|neuron projection|positive regulation of transport|regulation of sequestering of zinc ion SLC30A4 190.437050665995 186.012359332278 194.861741999712 1.0475741649598 0.0670523858168237 0.854329605342665 1 0.827181 0.867459 1.13278 0.649745 GeneID:7782,Genbank:NM_013309.5,HGNC:HGNC:11015,MIM:602095 solute carrier family 30 member 4 GO:0005385,GO:0005737,GO:0005765,GO:0005770,GO:0009636,GO:0010043,GO:0016020,GO:0016021,GO:0031902,GO:0055069,GO:0061088 zinc ion transmembrane transporter activity|cytoplasm|lysosomal membrane|late endosome|response to toxic substance|response to zinc ion|membrane|integral component of membrane|late endosome membrane|zinc ion homeostasis|regulation of sequestering of zinc ion SLC30A5 1439.68900800149 1523.83383537982 1355.54418062316 0.889561676050647 -0.168833459436839 0.249539127743157 1 13.7953 14.278 13.0532 11.5575 GeneID:64924,Genbank:NM_022902.4,HGNC:HGNC:19089,MIM:607819 solute carrier family 30 member 5 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding SLC30A6 570.469471361825 616.007548250147 524.931394473503 0.852150912703329 -0.230819145975242 0.338952879269129 1 3.57919 3.32604 3.36619 2.34714 GeneID:55676,Genbank:NM_001330479.1,HGNC:HGNC:19305,MIM:611148 solute carrier family 30 member 6 GO:0000139,GO:0005385,GO:0005794,GO:0010043,GO:0016020,GO:0016021,GO:0061088 Golgi membrane|zinc ion transmembrane transporter activity|Golgi apparatus|response to zinc ion|membrane|integral component of membrane|regulation of sequestering of zinc ion SLC30A7 433.68639274608 489.822117576245 377.550667915915 0.770791383990836 -0.375587649801687 0.0373615233995678 0.744556882325193 2.19709 2.25932 1.83567 1.47568 GeneID:148867,Genbank:NM_001144884.1,HGNC:HGNC:19306,MIM:611149 solute carrier family 30 member 7 GO:0005385,GO:0005737,GO:0005794,GO:0010043,GO:0016020,GO:0016021,GO:0031410,GO:0031982,GO:0032119,GO:0048471,GO:0061088,GO:0070062 zinc ion transmembrane transporter activity|cytoplasm|Golgi apparatus|response to zinc ion|membrane|integral component of membrane|cytoplasmic vesicle|vesicle|sequestering of zinc ion|perinuclear region of cytoplasm|regulation of sequestering of zinc ion|extracellular exosome SLC30A9 1072.71029301299 1126.15189902411 1019.26868700188 0.905089879868914 -0.143867028876548 0.441171630060996 1 12.9035 11.4533 12.4109 9.51691 GeneID:10463,Genbank:XM_017007654.2,HGNC:HGNC:1329,MIM:604604 solute carrier family 30 member 9 GO:0003682,GO:0003700,GO:0005634,GO:0005783,GO:0005856,GO:0006289,GO:0006351,GO:0006829,GO:0006882,GO:0008324,GO:0016021,GO:0016922,GO:0030374,GO:0031410,GO:0045944 chromatin binding|DNA binding transcription factor activity|nucleus|endoplasmic reticulum|cytoskeleton|nucleotide-excision repair|transcription, DNA-templated|zinc II ion transport|cellular zinc ion homeostasis|cation transmembrane transporter activity|integral component of membrane|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|cytoplasmic vesicle|positive regulation of transcription from RNA polymerase II promoter SLC31A1 1297.25846925199 1334.46944547471 1260.04749302928 0.94423105549715 -0.0827881613259542 0.563584421357412 1 10.6084 11.6414 11.0118 10.1999 GeneID:1317,Genbank:NM_001859.3,HGNC:HGNC:11016,MIM:603085 solute carrier family 31 member 1 GO:0005375,GO:0005770,GO:0005886,GO:0005887,GO:0006825,GO:0006855,GO:0006878,GO:0042802,GO:0043025,GO:0055037,GO:0072719,GO:0098705 copper ion transmembrane transporter activity|late endosome|plasma membrane|integral component of plasma membrane|copper ion transport|drug transmembrane transport|cellular copper ion homeostasis|identical protein binding|neuronal cell body|recycling endosome|cellular response to cisplatin|copper ion import across plasma membrane hsa01524,hsa04978 Platinum drug resistance|Mineral absorption SLC31A2 187.965919381866 174.318289270202 201.61354949353 1.15658288259713 0.209868655535111 0.383681092741002 1 0.915614 1.06053 1.3431 1.18774 GeneID:1318,Genbank:NM_001860.2,HGNC:HGNC:11017,MIM:603088 solute carrier family 31 member 2 GO:0005375,GO:0005770,GO:0005887,GO:0006825,GO:0006878,GO:0055037,GO:1902311 copper ion transmembrane transporter activity|late endosome|integral component of plasma membrane|copper ion transport|cellular copper ion homeostasis|recycling endosome|regulation of copper ion transmembrane transport SLC33A1 552.424149966977 471.919798422139 632.928501511816 1.34117810616975 0.423500837410653 0.0120626054863067 0.448247539370507 4.62605 4.05158 6.04666 5.75544 GeneID:9197,Genbank:NM_001190992.1,HGNC:HGNC:95,MIM:603690 solute carrier family 33 member 1 hsa00604 Glycosphingolipid biosynthesis - ganglio series SLC34A1 1.24125200715389 1.02816907859967 1.45433493570811 1.4144900541931 0.500282032643154 1 1 0.011148 0.00983867 0 0 GeneID:6569,Genbank:NM_003052.4,HGNC:HGNC:11019,MIM:182309 solute carrier family 34 member 1 GO:0001503,GO:0001822,GO:0005436,GO:0005737,GO:0005768,GO:0005886,GO:0005887,GO:0005903,GO:0006817,GO:0009100,GO:0009986,GO:0010288,GO:0015321,GO:0016324,GO:0016607,GO:0030165,GO:0030643,GO:0031526,GO:0031982,GO:0032026,GO:0032355,GO:0032403,GO:0033189,GO:0035864,GO:0042431,GO:0042493,GO:0042803,GO:0044267,GO:0045121,GO:0045838,GO:0046686,GO:0046689,GO:0048471,GO:0051260,GO:0055062,GO:0060416,GO:0071248,GO:0071374,GO:0072350,GO:0072686,GO:0072734,GO:0097066,GO:0097187,GO:1901128,GO:1901684,GO:2000120,GO:2000187 ossification|kidney development|sodium:phosphate symporter activity|cytoplasm|endosome|plasma membrane|integral component of plasma membrane|brush border|phosphate ion transport|glycoprotein metabolic process|cell surface|response to lead ion|sodium-dependent phosphate transmembrane transporter activity|apical plasma membrane|nuclear speck|PDZ domain binding|cellular phosphate ion homeostasis|brush border membrane|vesicle|response to magnesium ion|response to estradiol|protein complex binding|response to vitamin A|response to potassium ion|indole metabolic process|response to drug|protein homodimerization activity|cellular protein metabolic process|membrane raft|positive regulation of membrane potential|response to cadmium ion|response to mercury ion|perinuclear region of cytoplasm|protein homooligomerization|phosphate ion homeostasis|response to growth hormone|cellular response to metal ion|cellular response to parathyroid hormone stimulus|tricarboxylic acid metabolic process|mitotic spindle|cellular response to staurosporine|response to thyroid hormone|dentinogenesis|gentamycin metabolic process|arsenate ion transmembrane transport|positive regulation of sodium-dependent phosphate transport|positive regulation of phosphate transmembrane transport hsa04928 Parathyroid hormone synthesis, secretion and action SLC34A2 1.21723886981142 0.980142803914724 1.45433493570811 1.48379902387637 0.569295696478757 1 1 0 0.0101462 0.0210924 0.0098196 GeneID:10568,Genbank:NM_006424.2,HGNC:HGNC:11020,MIM:604217 solute carrier family 34 member 2 GO:0001701,GO:0005436,GO:0005737,GO:0005886,GO:0005887,GO:0005903,GO:0006817,GO:0015321,GO:0016021,GO:0016324,GO:0030643,GO:0031402,GO:0031526,GO:0031982,GO:0042301,GO:0043627,GO:0044267 in utero embryonic development|sodium:phosphate symporter activity|cytoplasm|plasma membrane|integral component of plasma membrane|brush border|phosphate ion transport|sodium-dependent phosphate transmembrane transporter activity|integral component of membrane|apical plasma membrane|cellular phosphate ion homeostasis|sodium ion binding|brush border membrane|vesicle|phosphate ion binding|response to estrogen|cellular protein metabolic process hsa04928,hsa04978 Parathyroid hormone synthesis, secretion and action|Mineral absorption SLC34A3 1.45596651333981 0.490071401957362 2.42186162472226 4.94185462577343 2.30505257162167 0.554081253978595 1 0 0.0175826 0.0190103 0.0177975 GeneID:142680,Genbank:NM_001177317.1,HGNC:HGNC:20305,MIM:609826 solute carrier family 34 member 3 GO:0005436,GO:0005737,GO:0005886,GO:0005903,GO:0006814,GO:0006817,GO:0015321,GO:0016021,GO:0016324,GO:0030643,GO:0031526,GO:0031982 sodium:phosphate symporter activity|cytoplasm|plasma membrane|brush border|sodium ion transport|phosphate ion transport|sodium-dependent phosphate transmembrane transporter activity|integral component of membrane|apical plasma membrane|cellular phosphate ion homeostasis|brush border membrane|vesicle hsa04928 Parathyroid hormone synthesis, secretion and action SLC35A1 238.814441364737 255.187845246565 222.441037482909 0.871675675884894 -0.198136643173654 0.362756008270973 1 5.81461 5.36326 4.8651 4.89925 GeneID:10559,Genbank:NM_006416.4,HGNC:HGNC:11021,MIM:605634 solute carrier family 35 member A1 GO:0000139,GO:0005351,GO:0005456,GO:0005794,GO:0005887,GO:0005975,GO:0006464,GO:0015782 Golgi membrane|sugar:proton symporter activity|CMP-N-acetylneuraminate transmembrane transporter activity|Golgi apparatus|integral component of plasma membrane|carbohydrate metabolic process|cellular protein modification process|CMP-N-acetylneuraminate transmembrane transport SLC35A2 624.967600548065 617.516997076451 632.41820401968 1.0241308450031 0.0344000487146683 0.841308837937071 1 9.15602 8.68696 9.33617 9.72473 GeneID:7355,Genbank:NM_001282647.1,HGNC:HGNC:11022,MIM:314375 solute carrier family 35 member A2 GO:0000139,GO:0005351,GO:0005459,GO:0005634,GO:0005783,GO:0005794,GO:0006012,GO:0016021,GO:0072334 Golgi membrane|sugar:proton symporter activity|UDP-galactose transmembrane transporter activity|nucleus|endoplasmic reticulum|Golgi apparatus|galactose metabolic process|integral component of membrane|UDP-galactose transmembrane transport SLC35A3 212.353900994056 231.328234029817 193.379567958296 0.835953158806244 -0.258505989245321 0.260943078449076 1 1.25305 1.06757 1.17533 0.966085 GeneID:23443,Genbank:XM_005270691.5,HGNC:HGNC:11023,MIM:605632 solute carrier family 35 member A3 GO:0000139,GO:0005351,GO:0005462,GO:0005794,GO:0006047,GO:0016021,GO:1990569 Golgi membrane|sugar:proton symporter activity|UDP-N-acetylglucosamine transmembrane transporter activity|Golgi apparatus|UDP-N-acetylglucosamine metabolic process|integral component of membrane|UDP-N-acetylglucosamine transmembrane transport SLC35A4 3369.97606404249 3315.12895236707 3424.82317571791 1.03308897630438 0.0469645137819543 0.738652172451569 1 55.3405 56.4373 59.6751 58.3481 GeneID:113829,Genbank:NM_080670.3,HGNC:HGNC:20753 solute carrier family 35 member A4 GO:0000139,GO:0005351,GO:0005794,GO:0016021 Golgi membrane|sugar:proton symporter activity|Golgi apparatus|integral component of membrane SLC35A5 454.299888832577 469.987921778779 438.611855886375 0.933240697391427 -0.0996788721724603 0.644789206099067 1 4.4268 3.64526 4.23996 3.56364 GeneID:55032,Genbank:NM_001348906.1,HGNC:HGNC:20792 solute carrier family 35 member A5 GO:0000139,GO:0005351,GO:0016021 Golgi membrane|sugar:proton symporter activity|integral component of membrane SLC35B1 1889.72027375307 1870.5199369675 1908.92061053863 1.02052941153537 0.0293177612680137 0.838379075335063 1 37.8491 37.3755 39.3663 39.5832 GeneID:10237,Genbank:NM_001278784.1,HGNC:HGNC:20798,MIM:610790 solute carrier family 35 member B1 GO:0005459,GO:0006810,GO:0008643,GO:0030173,GO:0030176,GO:0043231 UDP-galactose transmembrane transporter activity|transport|carbohydrate transport|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|intracellular membrane-bounded organelle SLC35B2 4243.47408964782 3792.39354393776 4694.55463535787 1.23788699167633 0.307879615045056 0.0227113636337814 0.612664613324667 82.2377 85.6901 107.928 104.708 GeneID:347734,Genbank:NM_001286511.1,HGNC:HGNC:16872,MIM:610788 solute carrier family 35 member B2 GO:0000139,GO:0004871,GO:0005794,GO:0016020,GO:0016021,GO:0030173,GO:0030176,GO:0043123,GO:0046963,GO:0046964,GO:0050428 Golgi membrane|signal transducer activity|Golgi apparatus|membrane|integral component of membrane|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|3'-phosphoadenosine 5'-phosphosulfate transport|3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process SLC35B3 436.857227680633 431.73496046249 441.979494898776 1.0237287580911 0.0338335169070025 0.844706762237826 1 4.33052 4.05431 4.23615 4.20665 GeneID:51000,Genbank:NM_001142541.2,HGNC:HGNC:21601,MIM:610845 solute carrier family 35 member B3 GO:0000139,GO:0030173,GO:0030176,GO:0046964,GO:0050428 Golgi membrane|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process SLC35B4 1092.25372579103 1274.83462191507 909.672829666993 0.713561440856126 -0.486890437292614 0.00124886963455653 0.116970152438932 7.84871 8.02134 6.05454 5.38092 GeneID:84912,Genbank:NM_032826.4,HGNC:HGNC:20584,MIM:610923 solute carrier family 35 member B4 GO:0000139,GO:0005457,GO:0005462,GO:0005464,GO:0005783,GO:0005794,GO:0006111,GO:0008643,GO:0015783,GO:0015790,GO:0030173,GO:0030176,GO:1990569 Golgi membrane|GDP-fucose transmembrane transporter activity|UDP-N-acetylglucosamine transmembrane transporter activity|UDP-xylose transmembrane transporter activity|endoplasmic reticulum|Golgi apparatus|regulation of gluconeogenesis|carbohydrate transport|GDP-fucose transmembrane transport|UDP-xylose transmembrane transport|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|UDP-N-acetylglucosamine transmembrane transport SLC35C1 1041.71935986756 1101.12309090727 982.31562882786 0.892103377850775 -0.164717194079324 0.267554355817858 1 11.0602 11.3168 10.1392 10.3755 GeneID:55343,Genbank:NM_001145265.1,HGNC:HGNC:20197,MIM:605881 solute carrier family 35 member C1 SLC35C2 1090.07009901564 1073.30469085528 1106.83550717601 1.0312407246576 0.0443811433093285 0.787371580107773 1 4.03017 4.28664 4.30231 4.49751 GeneID:51006,Genbank:NM_001281458.1,HGNC:HGNC:17117 solute carrier family 35 member C2 GO:0005654,GO:0005793,GO:0005794,GO:0005801,GO:0010629,GO:0015786,GO:0016021,GO:0033116,GO:0036066,GO:0045747 nucleoplasm|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|negative regulation of gene expression|UDP-glucose transmembrane transport|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|protein O-linked fucosylation|positive regulation of Notch signaling pathway SLC35D1 580.365505635351 605.283812336878 555.447198933825 0.917664057112903 -0.123961993361921 0.543338688165945 1 4.89187 4.34644 4.92738 3.64312 GeneID:23169,Genbank:NM_015139.2,HGNC:HGNC:20800,MIM:610804 solute carrier family 35 member D1 GO:0005461,GO:0005789,GO:0006065,GO:0008643,GO:0015165,GO:0016021,GO:0030206,GO:0048706 UDP-glucuronic acid transmembrane transporter activity|endoplasmic reticulum membrane|UDP-glucuronate biosynthetic process|carbohydrate transport|pyrimidine nucleotide-sugar transmembrane transporter activity|integral component of membrane|chondroitin sulfate biosynthetic process|embryonic skeletal system development SLC35D2 749.027083440275 698.886433109879 799.167733770671 1.14348726189256 0.193440294646134 0.226955712192418 1 17.9592 16.8134 20.7924 19.679 GeneID:11046,Genbank:NM_001286990.1,HGNC:HGNC:20799,MIM:609182 solute carrier family 35 member D2 GO:0000139,GO:0005338,GO:0005794,GO:0006024,GO:0008643,GO:0015165,GO:0016021,GO:0018146 Golgi membrane|nucleotide-sugar transmembrane transporter activity|Golgi apparatus|glycosaminoglycan biosynthetic process|carbohydrate transport|pyrimidine nucleotide-sugar transmembrane transporter activity|integral component of membrane|keratan sulfate biosynthetic process SLC35D3 3.99487142344122 4.11267631439867 3.87706653248377 0.942711323745559 -0.0851120372001571 1 1 0.0973694 0.0885365 0.0922564 0.0857082 GeneID:340146,Genbank:NM_001008783.2,HGNC:HGNC:15621,MIM:612519 solute carrier family 35 member D3 GO:0005769,GO:0005783,GO:0015165,GO:0016021,GO:0034219,GO:0070863,GO:0090481,GO:0097009 early endosome|endoplasmic reticulum|pyrimidine nucleotide-sugar transmembrane transporter activity|integral component of membrane|carbohydrate transmembrane transport|positive regulation of protein exit from endoplasmic reticulum|pyrimidine nucleotide-sugar transmembrane transport|energy homeostasis SLC35E1 2710.38033724384 2552.69896713871 2868.06170734898 1.12354090485011 0.168052649796096 0.232288560393537 1 20.0274 22.2959 24.8788 22.9986 GeneID:79939,Genbank:NM_024881.4,HGNC:HGNC:20803 solute carrier family 35 member E1 GO:0005794,GO:0016021 Golgi apparatus|integral component of membrane SLC35E2A 212.502508941587 215.685183787613 209.319834095561 0.970487774912158 -0.0432180552453728 0.896363633858532 1 1.58576 1.8011 1.40874 1.7788 GeneID:9906,Genbank:NM_001199787.1,HGNC:HGNC:20863 solute carrier family 35 member E2A GO:0016021 integral component of membrane SLC35E2B 1980.52321178443 1988.01936957598 1973.02705399289 0.992458667248153 -0.0109210750476974 0.940908596922808 1 13.8807 13.7231 15.0155 12.759 GeneID:728661,Genbank:XM_024449510.1,HGNC:HGNC:33941 solute carrier family 35 member E2B GO:0016021 integral component of membrane SLC35E3 422.141564954167 403.244192564917 441.038937343417 1.09372669334206 0.129252274309009 0.473492581589438 1 2.80929 2.716 3.38317 2.85631 GeneID:55508,Genbank:NM_018656.3,HGNC:HGNC:20864 solute carrier family 35 member E3 GO:0016021 integral component of membrane SLC35E4 213.175227359042 204.875203980082 221.475250738002 1.08102516280854 0.112400104790045 0.64047490601326 1 1.34073 1.52246 1.6323 1.56521 GeneID:339665,Genbank:XM_017028794.1,HGNC:HGNC:17058 solute carrier family 35 member E4 GO:0016021 integral component of membrane SLC35F1 578.487879262322 614.662812558969 542.312945965675 0.882293405237765 -0.180669593423411 0.289562765685076 1 5.67254 5.58396 5.30546 4.73898 GeneID:222553,Genbank:XM_005266865.4,HGNC:HGNC:21483 solute carrier family 35 member F1 GO:0016021,GO:0022857 integral component of membrane|transmembrane transporter activity SLC35F2 1990.4560862979 2152.34412570829 1828.56804688752 0.84957048691541 -0.235194445412353 0.0944030685427761 0.994506734213175 32.0419 32.039 29.226 25.5184 GeneID:54733,Genbank:NM_017515.4,HGNC:HGNC:23615 solute carrier family 35 member F2 GO:0016021,GO:0022857 integral component of membrane|transmembrane transporter activity SLC35F3 1.23875045746879 0.538097676642304 1.93940323829528 3.60418437484629 1.84967281522267 0.680545261345893 1 0.0163473 0 0.015446 0.0143642 GeneID:148641,Genbank:NM_173508.3,HGNC:HGNC:23616 solute carrier family 35 member F3 GO:0015888,GO:0016021 thiamine transport|integral component of membrane SLC35F5 685.073761405232 758.989676759547 611.157846050917 0.805225505385281 -0.312535224776529 0.120466054667981 1 2.22333 1.95609 1.83018 1.48994 GeneID:80255,Genbank:XM_017005027.1,HGNC:HGNC:23617 solute carrier family 35 member F5 GO:0016021 integral component of membrane SLC35F6 1053.44797163906 1070.77688160549 1036.11906167263 0.967633014376543 -0.0474681018564449 0.751232333209314 1 11.8144 11.9759 11.6727 11.6096 GeneID:54978,Genbank:NM_017877.3,HGNC:HGNC:26055 solute carrier family 35 member F6 GO:0005654,GO:0005739,GO:0005765,GO:0005829,GO:0008284,GO:0016021,GO:0022857,GO:0043231,GO:0070062,GO:1901029 nucleoplasm|mitochondrion|lysosomal membrane|cytosol|positive regulation of cell proliferation|integral component of membrane|transmembrane transporter activity|intracellular membrane-bounded organelle|extracellular exosome|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway SLC35G1 144.871833672202 165.179420421536 124.564246922869 0.754114808037118 -0.407143915721002 0.142335290354834 1 1.38609 1.10474 1.05033 0.802963 GeneID:159371,Genbank:XM_011539373.3,HGNC:HGNC:26607,MIM:617167 solute carrier family 35 member G1 GO:0005789,GO:0005886,GO:0016021,GO:0051480,GO:1990034 endoplasmic reticulum membrane|plasma membrane|integral component of membrane|regulation of cytosolic calcium ion concentration|calcium ion export across plasma membrane SLC35G2 372.483459437028 420.732875556219 324.234043317836 0.770641093566057 -0.37586897675485 0.04563646098412 0.79332376136203 2.03029 2.08939 1.73171 1.48516 GeneID:80723,Genbank:NM_025246.2,HGNC:HGNC:28480,MIM:617812 solute carrier family 35 member G2 GO:0005794,GO:0005886,GO:0005887 Golgi apparatus|plasma membrane|integral component of plasma membrane SLC35G5 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0591144 0 0 0 GeneID:83650,Genbank:NM_054028.1,HGNC:HGNC:15546,MIM:615199 solute carrier family 35 member G5 GO:0016021 integral component of membrane SLC35G6 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.121733 0 0 0 GeneID:643664,Genbank:NM_001102614.1,HGNC:HGNC:31351 solute carrier family 35 member G6 GO:0016021 integral component of membrane SLC36A1 377.880231684657 395.154127105921 360.606336263394 0.912571352612326 -0.131990729393113 0.50260988291854 1 0.912588 1.02427 1.06496 0.786169 GeneID:206358,Genbank:XM_011537591.1,HGNC:HGNC:18761,MIM:606561 solute carrier family 36 member 1 GO:0005280,GO:0005765,GO:0005783,GO:0005886,GO:0006811,GO:0006865,GO:0015078,GO:0015171,GO:0015180,GO:0015187,GO:0015193,GO:0015816,GO:0016021 hydrogen:amino acid symporter activity|lysosomal membrane|endoplasmic reticulum|plasma membrane|ion transport|amino acid transport|hydrogen ion transmembrane transporter activity|amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|glycine transmembrane transporter activity|L-proline transmembrane transporter activity|glycine transport|integral component of membrane hsa04974 Protein digestion and absorption SLC36A4 393.245835966578 421.049442168798 365.442229764358 0.867931870143299 -0.204346294687707 0.283136682216657 1 2.38801 2.27344 2.38287 1.83288 GeneID:120103,Genbank:NM_152313.3,HGNC:HGNC:19660,MIM:613760 solute carrier family 36 member 4 GO:0005774,GO:0005886,GO:0015180,GO:0015193,GO:0015196,GO:0015293,GO:0015808,GO:0015824,GO:0015827,GO:0016021,GO:1904271,GO:1904556 vacuolar membrane|plasma membrane|L-alanine transmembrane transporter activity|L-proline transmembrane transporter activity|L-tryptophan transmembrane transporter activity|symporter activity|L-alanine transport|proline transport|tryptophan transport|integral component of membrane|L-proline import across plasma membrane|L-tryptophan transmembrane transport SLC37A1 104.216927113418 89.2105784647463 119.22327576209 1.33642531876647 0.418379220105796 0.155102994454305 1 0.218156 0.216173 0.299441 0.297319 GeneID:54020,Genbank:NM_018964.3,HGNC:HGNC:11024,MIM:608094 solute carrier family 37 member 1 GO:0005789,GO:0008643,GO:0015760,GO:0016020,GO:0030176,GO:0035435,GO:0061513 endoplasmic reticulum membrane|carbohydrate transport|glucose-6-phosphate transport|membrane|integral component of endoplasmic reticulum membrane|phosphate ion transmembrane transport|glucose 6-phosphate:inorganic phosphate antiporter activity SLC37A2 74.0537328640124 69.1274596396024 78.9800060884224 1.14252724604935 0.192228569897425 0.604767810485927 1 0.763384 0.571963 0.605533 0.961198 GeneID:219855,Genbank:NM_198277.2,HGNC:HGNC:20644 solute carrier family 37 member 2 GO:0005789,GO:0008643,GO:0015760,GO:0030176,GO:0035435,GO:0061513,GO:0070062 endoplasmic reticulum membrane|carbohydrate transport|glucose-6-phosphate transport|integral component of endoplasmic reticulum membrane|phosphate ion transmembrane transport|glucose 6-phosphate:inorganic phosphate antiporter activity|extracellular exosome SLC37A3 1280.19320623293 1230.06665354928 1330.31975891657 1.08150217313673 0.113036564209216 0.452165330416791 1 15.1306 16.3292 18.0706 16.7818 GeneID:84255,Genbank:NM_032295.3,HGNC:HGNC:20651 solute carrier family 37 member 3 GO:0005829,GO:0008643,GO:0022857,GO:0030176 cytosol|carbohydrate transport|transmembrane transporter activity|integral component of endoplasmic reticulum membrane SLC37A4 852.329029936337 883.765779159934 820.89228071274 0.928857283309884 -0.106471147879042 0.502744921157398 1 13.0095 13.8915 12.1632 12.9546 GeneID:2542,Genbank:NM_001164279.1,HGNC:HGNC:4061,MIM:602671 solute carrier family 37 member 4 hsa04973 Carbohydrate digestion and absorption SLC38A1 2767.67877648798 2783.18503518354 2752.17251779241 0.988857184485011 -0.0161659198211854 0.967529363519629 1 9.71357 8.77221 11.1598 7.40798 GeneID:81539,Genbank:NM_001077484.1,HGNC:HGNC:13447,MIM:608490 solute carrier family 38 member 1 GO:0001504,GO:0003333,GO:0005283,GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015175,GO:0015179,GO:0015804,GO:0016021,GO:0070062 neurotransmitter uptake|amino acid transmembrane transport|sodium:amino acid symporter activity|plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|neutral amino acid transport|integral component of membrane|extracellular exosome hsa04724,hsa04727 Glutamatergic synapse|GABAergic synapse SLC38A10 2558.33155013413 2211.76926086068 2904.89383940757 1.31338014810694 0.393284554014811 0.0048270628764315 0.278092687125054 16.7426 18.0673 24.316 22.4468 GeneID:124565,Genbank:NM_001037984.2,HGNC:HGNC:28237,MIM:616525 solute carrier family 38 member 10 GO:0003333,GO:0005794,GO:0006814,GO:0015171,GO:0016021,GO:0060348 amino acid transmembrane transport|Golgi apparatus|sodium ion transport|amino acid transmembrane transporter activity|integral component of membrane|bone development SLC38A2 4503.58565284299 4756.27768063417 4250.89362505181 0.893743786734719 -0.162066787623005 0.567578096119544 1 47.5617 42.878 48.9311 32.0464 GeneID:54407,Genbank:NM_001307936.1,HGNC:HGNC:13448,MIM:605180 solute carrier family 38 member 2 GO:0003333,GO:0005886,GO:0005887,GO:0005903,GO:0006814,GO:0006865,GO:0007565,GO:0014047,GO:0015171,GO:0015186,GO:0015293,GO:0021987,GO:0030424,GO:0030425,GO:0031460,GO:0032328,GO:0034198,GO:0042383,GO:0043025,GO:0071260 amino acid transmembrane transport|plasma membrane|integral component of plasma membrane|brush border|sodium ion transport|amino acid transport|female pregnancy|glutamate secretion|amino acid transmembrane transporter activity|L-glutamine transmembrane transporter activity|symporter activity|cerebral cortex development|axon|dendrite|glycine betaine transport|alanine transport|cellular response to amino acid starvation|sarcolemma|neuronal cell body|cellular response to mechanical stimulus hsa04724,hsa04727,hsa04974 Glutamatergic synapse|GABAergic synapse|Protein digestion and absorption SLC38A3 566.343688755999 420.224203844901 712.463173667097 1.69543583436726 0.761656185016921 9.50609565930238e-06 0.00434998937369677 4.57742 5.30918 9.65098 7.57809 GeneID:10991,Genbank:NM_006841.5,HGNC:HGNC:18044,MIM:604437 solute carrier family 38 member 3 GO:0005290,GO:0005886,GO:0005887,GO:0006814,GO:0006865,GO:0006867,GO:0006868,GO:0007420,GO:0007565,GO:0015171,GO:0015180,GO:0015182,GO:0015186,GO:0015293,GO:0015297,GO:0015808,GO:0015817,GO:0016323,GO:0051365,GO:0061402,GO:2000487 L-histidine transmembrane transporter activity|plasma membrane|integral component of plasma membrane|sodium ion transport|amino acid transport|asparagine transport|glutamine transport|brain development|female pregnancy|amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|symporter activity|antiporter activity|L-alanine transport|histidine transport|basolateral plasma membrane|cellular response to potassium ion starvation|positive regulation of transcription from RNA polymerase II promoter in response to acidic pH|positive regulation of glutamine transport hsa04724,hsa04727,hsa04964 Glutamatergic synapse|GABAergic synapse|Proximal tubule bicarbonate reclamation SLC38A4 3.18946485258456 2.49838328447175 3.88054642069736 1.55322301618658 0.635264990862904 0.858862366027184 1 0.011351 0.0436866 0.0547834 0 GeneID:55089,Genbank:XM_005268997.2,HGNC:HGNC:14679,MIM:608065 solute carrier family 38 member 4 GO:0003333,GO:0005886,GO:0005887,GO:0006814,GO:0006865,GO:0015171,GO:0015293 amino acid transmembrane transport|plasma membrane|integral component of plasma membrane|sodium ion transport|amino acid transport|amino acid transmembrane transporter activity|symporter activity SLC38A5 0.996216306175209 0.538097676642304 1.45433493570811 2.70273409241064 1.43441957978558 0.835201184388344 1 0.021122 0 0 0.018316 GeneID:92745,Genbank:NM_033518.3,HGNC:HGNC:18070,MIM:300649 solute carrier family 38 member 5 GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015187 plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|glycine transmembrane transporter activity hsa04727 GABAergic synapse SLC38A6 248.242142151573 240.60137304743 255.882911255715 1.0635139276835 0.0888389268278247 0.682102859202305 1 1.046 1.34921 1.17635 1.22923 GeneID:145389,Genbank:NM_001172702.1,HGNC:HGNC:19863,MIM:616518 solute carrier family 38 member 6 GO:0003333,GO:0005886,GO:0005887,GO:0006814,GO:0015171 amino acid transmembrane transport|plasma membrane|integral component of plasma membrane|sodium ion transport|amino acid transmembrane transporter activity SLC38A7 614.809536302288 567.070085641021 662.548986963555 1.16837231188911 0.224500074668308 0.20429215266075 1 3.90449 4.29273 5.71006 4.40777 GeneID:55238,Genbank:NM_018231.2,HGNC:HGNC:25582,MIM:614236 solute carrier family 38 member 7 GO:0005290,GO:0005313,GO:0006814,GO:0006867,GO:0015179,GO:0015180,GO:0015182,GO:0015183,GO:0015186,GO:0015190,GO:0015191,GO:0015194,GO:0015808,GO:0015825,GO:0016021,GO:0030424,GO:0043025 L-histidine transmembrane transporter activity|L-glutamate transmembrane transporter activity|sodium ion transport|asparagine transport|L-amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-aspartate transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-leucine transmembrane transporter activity|L-methionine transmembrane transporter activity|L-serine transmembrane transporter activity|L-alanine transport|L-serine transport|integral component of membrane|axon|neuronal cell body SLC38A9 378.428992450628 425.844294983894 331.013689917363 0.777311552171627 -0.363435137586996 0.0558731929574387 0.857612445291018 4.31565 4.00895 3.5082 2.93533 GeneID:153129,Genbank:XM_006714539.3,HGNC:HGNC:26907,MIM:616203 solute carrier family 38 member 9 GO:0003333,GO:0005654,GO:0005764,GO:0005765,GO:0005770,GO:0007050,GO:0015171,GO:0016021,GO:0016241,GO:0031902,GO:0032008,GO:0043231,GO:0071230 amino acid transmembrane transport|nucleoplasm|lysosome|lysosomal membrane|late endosome|cell cycle arrest|amino acid transmembrane transporter activity|integral component of membrane|regulation of macroautophagy|late endosome membrane|positive regulation of TOR signaling|intracellular membrane-bounded organelle|cellular response to amino acid stimulus hsa04150 mTOR signaling pathway SLC39A1 5233.74225662224 5173.61289469801 5293.87161854646 1.02324463122699 0.0331510972500732 0.827091023825979 1 80.7072 87.681 85.2591 89.3035 GeneID:27173,Genbank:NM_001271960.1,HGNC:HGNC:12876,MIM:604740 solute carrier family 39 member 1 SLC39A10 373.047922910258 453.844991479509 292.250854341005 0.643944209648065 -0.634992394048502 0.000831478643710881 0.0905241727626952 1.69168 1.49855 1.13669 0.912696 GeneID:57181,Genbank:XM_011511505.3,HGNC:HGNC:20861,MIM:608733 solute carrier family 39 member 10 GO:0002903,GO:0005385,GO:0005887,GO:0006882,GO:0030890,GO:0050861,GO:0071578,GO:1903615 negative regulation of B cell apoptotic process|zinc ion transmembrane transporter activity|integral component of plasma membrane|cellular zinc ion homeostasis|positive regulation of B cell proliferation|positive regulation of B cell receptor signaling pathway|zinc II ion transmembrane import|positive regulation of protein tyrosine phosphatase activity SLC39A11 354.338608491983 348.108289518869 360.568927465098 1.03579529221625 0.0507389064162139 0.826845675235637 1 1.14248 1.40207 1.30128 1.19965 GeneID:201266,Genbank:NM_139177.3,HGNC:HGNC:14463,MIM:616508 solute carrier family 39 member 11 GO:0005385,GO:0005634,GO:0005737,GO:0005794,GO:0005886,GO:0016020,GO:0016021,GO:0071577 zinc ion transmembrane transporter activity|nucleus|cytoplasm|Golgi apparatus|plasma membrane|membrane|integral component of membrane|zinc II ion transmembrane transport SLC39A13 1446.86195542778 1393.33483163853 1500.38907921703 1.07683310942037 0.106794674331141 0.476544239954076 1 19.4847 19.9829 21.4233 20.9801 GeneID:91252,Genbank:XM_011520467.1,HGNC:HGNC:20859,MIM:608735 solute carrier family 39 member 13 GO:0005385,GO:0005783,GO:0005794,GO:0006882,GO:0010043,GO:0016021,GO:0030173,GO:0042803,GO:0048471,GO:0061448,GO:0071577 zinc ion transmembrane transporter activity|endoplasmic reticulum|Golgi apparatus|cellular zinc ion homeostasis|response to zinc ion|integral component of membrane|integral component of Golgi membrane|protein homodimerization activity|perinuclear region of cytoplasm|connective tissue development|zinc II ion transmembrane transport SLC39A14 3480.19993822239 3339.533418913 3620.86645753177 1.08424321703909 0.116688417815098 0.383596224168358 1 24.2474 23.4697 28.909 24.1092 GeneID:23516,Genbank:NM_001135154.2,HGNC:HGNC:20858,MIM:608736 solute carrier family 39 member 14 GO:0005384,GO:0005385,GO:0005737,GO:0005886,GO:0005887,GO:0006882,GO:0015093,GO:0016021,GO:0030027,GO:0071577,GO:0071578 manganese ion transmembrane transporter activity|zinc ion transmembrane transporter activity|cytoplasm|plasma membrane|integral component of plasma membrane|cellular zinc ion homeostasis|ferrous iron transmembrane transporter activity|integral component of membrane|lamellipodium|zinc II ion transmembrane transport|zinc II ion transmembrane import hsa04216 Ferroptosis SLC39A2 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0.0369171 GeneID:29986,Genbank:NM_014579.3,HGNC:HGNC:17127,MIM:612166 solute carrier family 39 member 2 GO:0005385,GO:0005886,GO:0005887,GO:0006829,GO:0031410 zinc ion transmembrane transporter activity|plasma membrane|integral component of plasma membrane|zinc II ion transport|cytoplasmic vesicle SLC39A3 1058.74528558871 1017.88063016113 1099.60994101629 1.08029361050149 0.111423472431251 0.492448396900972 1 8.74024 10.2563 10.6561 10.4537 GeneID:29985,Genbank:NM_144564.4,HGNC:HGNC:17128,MIM:612168 solute carrier family 39 member 3 GO:0000902,GO:0001701,GO:0005385,GO:0005886,GO:0016020,GO:0016021,GO:0043029,GO:0048701,GO:0060173,GO:0071577 cell morphogenesis|in utero embryonic development|zinc ion transmembrane transporter activity|plasma membrane|membrane|integral component of membrane|T cell homeostasis|embryonic cranial skeleton morphogenesis|limb development|zinc II ion transmembrane transport SLC39A5 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0 0 GeneID:283375,Genbank:XM_011538200.2,HGNC:HGNC:20502,MIM:608730 solute carrier family 39 member 5 GO:0001654,GO:0005385,GO:0005887,GO:0006882,GO:0016323,GO:0030509,GO:0034224,GO:0048026,GO:0061351,GO:0070062,GO:0070315,GO:0071578 eye development|zinc ion transmembrane transporter activity|integral component of plasma membrane|cellular zinc ion homeostasis|basolateral plasma membrane|BMP signaling pathway|cellular response to zinc ion starvation|positive regulation of mRNA splicing, via spliceosome|neural precursor cell proliferation|extracellular exosome|G1 to G0 transition involved in cell differentiation|zinc II ion transmembrane import SLC39A6 720.953950895735 790.488516653765 651.419385137706 0.824071914283137 -0.279157852318035 0.194315374793485 1 6.78206 5.8805 5.96538 4.33733 GeneID:25800,Genbank:XM_011525901.2,HGNC:HGNC:18607,MIM:608731 solute carrier family 39 member 6 SLC39A7 7567.43659270253 6883.51590733905 8251.357278066 1.19871260401514 0.261485808491828 0.0480738374383458 0.805544588686926 88.3842 93.0107 115.673 106.861 GeneID:7922,Genbank:NM_006979.2,HGNC:HGNC:4927,MIM:601416 solute carrier family 39 member 7 GO:0005385,GO:0005654,GO:0005783,GO:0005789,GO:0005794,GO:0006882,GO:0016020,GO:0016021,GO:0071577 zinc ion transmembrane transporter activity|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cellular zinc ion homeostasis|membrane|integral component of membrane|zinc II ion transmembrane transport SLC39A8 597.329336283035 636.782652231096 557.876020334974 0.876085456129094 -0.190856493188135 0.30590712930565 1 2.76979 2.9917 2.98121 2.14827 GeneID:64116,Genbank:NM_001135147.1,HGNC:HGNC:20862,MIM:608732 solute carrier family 39 member 8 GO:0005385,GO:0005886,GO:0005887,GO:0006829,GO:0006882,GO:0031090,GO:0070574,GO:0071578 zinc ion transmembrane transporter activity|plasma membrane|integral component of plasma membrane|zinc II ion transport|cellular zinc ion homeostasis|organelle membrane|cadmium ion transmembrane transport|zinc II ion transmembrane import hsa04216 Ferroptosis SLC39A9 1470.43746530092 1327.49277598772 1613.38215461413 1.21536040255564 0.281384193566922 0.0535016872259918 0.844219726710823 9.66258 10.1189 12.8483 11.4486 GeneID:55334,Genbank:XM_024449648.1,HGNC:HGNC:20182 solute carrier family 39 member 9 GO:0006829,GO:0016021,GO:0046873 zinc II ion transport|integral component of membrane|metal ion transmembrane transporter activity SLC3A1 12.4048115957282 14.63449847382 10.1751247176364 0.69528345886529 -0.524326827372147 0.570777362579695 1 0.157204 0.0755648 0.0504514 0.101443 GeneID:6519,Genbank:NM_000341.3,HGNC:HGNC:11025,MIM:104614 solute carrier family 3 member 1 hsa04974 Protein digestion and absorption SLC3A2 6957.03582940854 6596.75583796168 7317.31582085539 1.10922944559312 0.149557819765643 0.398054456424478 1 119.17 130.191 131.741 149.89 GeneID:6520,Genbank:NM_002394.5,HGNC:HGNC:11026,MIM:158070 solute carrier family 3 member 2 GO:0003723,GO:0003725,GO:0003824,GO:0005432,GO:0005634,GO:0005829,GO:0005886,GO:0005975,GO:0006816,GO:0006865,GO:0009986,GO:0015175,GO:0015827,GO:0016020,GO:0016021,GO:0016049,GO:0016324,GO:0042470,GO:0043330,GO:0045296,GO:0050900,GO:0060356,GO:0070062,GO:1902475 RNA binding|double-stranded RNA binding|catalytic activity|calcium:sodium antiporter activity|nucleus|cytosol|plasma membrane|carbohydrate metabolic process|calcium ion transport|amino acid transport|cell surface|neutral amino acid transmembrane transporter activity|tryptophan transport|membrane|integral component of membrane|cell growth|apical plasma membrane|melanosome|response to exogenous dsRNA|cadherin binding|leukocyte migration|leucine import|extracellular exosome|L-alpha-amino acid transmembrane transport hsa04150,hsa04216,hsa04974 mTOR signaling pathway|Ferroptosis|Protein digestion and absorption SLC40A1 2.2379032993558 1.56626675524197 2.90953984346962 1.85762727436562 0.893461059649856 0.765255693959009 1 0.0263004 0.0125313 0.0631862 0.011747 GeneID:30061,Genbank:NM_014585.5,HGNC:HGNC:10909,MIM:604653 solute carrier family 40 member 1 GO:0002260,GO:0003158,GO:0004872,GO:0005381,GO:0005622,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006879,GO:0008021,GO:0015093,GO:0016021,GO:0016323,GO:0017046,GO:0034395,GO:0034755,GO:0042802,GO:0043066,GO:0045944,GO:0060345,GO:0060586,GO:0097689,GO:1903988 lymphocyte homeostasis|endothelium development|receptor activity|iron ion transmembrane transporter activity|intracellular|nucleoplasm|cytoplasm|cytosol|plasma membrane|integral component of plasma membrane|cellular iron ion homeostasis|synaptic vesicle|ferrous iron transmembrane transporter activity|integral component of membrane|basolateral plasma membrane|peptide hormone binding|regulation of transcription from RNA polymerase II promoter in response to iron|iron ion transmembrane transport|identical protein binding|negative regulation of apoptotic process|positive regulation of transcription from RNA polymerase II promoter|spleen trabecula formation|multicellular organismal iron ion homeostasis|iron channel activity|ferrous iron export across plasma membrane hsa04216,hsa04978 Ferroptosis|Mineral absorption SLC41A1 1241.64275353737 1320.66018532478 1162.62532174996 0.880336467070852 -0.18387306363925 0.21544611098295 1 10.1621 9.80628 9.20665 8.64822 GeneID:254428,Genbank:NM_173854.5,HGNC:HGNC:19429,MIM:610801 solute carrier family 41 member 1 GO:0010961,GO:0015095,GO:0016021,GO:0016323,GO:0043234,GO:0061768,GO:0071286,GO:0072509 cellular magnesium ion homeostasis|magnesium ion transmembrane transporter activity|integral component of membrane|basolateral plasma membrane|protein complex|magnesium:sodium antiporter activity|cellular response to magnesium ion|divalent inorganic cation transmembrane transporter activity SLC41A2 183.476195292993 177.911468217319 189.040922368666 1.06255613684078 0.0875390635584679 0.788242916144677 1 0.685811 0.536338 0.800297 0.452324 GeneID:84102,Genbank:XM_017020013.1,HGNC:HGNC:31045,MIM:610802 solute carrier family 41 member 2 GO:0005886,GO:0015095,GO:0016021,GO:0055085,GO:0072509 plasma membrane|magnesium ion transmembrane transporter activity|integral component of membrane|transmembrane transport|divalent inorganic cation transmembrane transporter activity SLC41A3 1031.33656789168 960.196283554212 1102.47685222915 1.14817862879898 0.199347107897683 0.197086725963213 1 11.813 11.9352 12.8707 13.4553 GeneID:54946,Genbank:XM_005247563.2,HGNC:HGNC:31046,MIM:610803 solute carrier family 41 member 3 GO:0005886,GO:0008324,GO:0016021,GO:0055085 plasma membrane|cation transmembrane transporter activity|integral component of membrane|transmembrane transport SLC43A1 60.4041164134901 62.1802161179373 58.6280167090428 0.942872514271145 -0.0848653774995595 0.8467883889898 1 0.743516 0.647333 0.480859 0.874002 GeneID:8501,Genbank:XM_017018451.2,HGNC:HGNC:9225,MIM:603733 solute carrier family 43 member 1 GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015175,GO:0015179,GO:0015804 plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|neutral amino acid transport SLC43A2 114.528107840738 125.330766384681 103.725449296795 0.827613620253686 -0.272970706684659 0.350972237529628 1 0.55621 0.425754 0.49731 0.306901 GeneID:124935,Genbank:NM_152346.2,HGNC:HGNC:23087,MIM:610791 solute carrier family 43 member 2 GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015175,GO:0015179 plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity SLC43A3 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0292506 0 0 GeneID:29015,Genbank:NM_017611.2,HGNC:HGNC:17466 solute carrier family 43 member 3 GO:0016021,GO:0055085 integral component of membrane|transmembrane transport SLC44A1 1094.7639438592 1064.13537904044 1125.39250867795 1.05756516590281 0.0807465632300768 0.573169830379938 1 3.86345 3.48506 4.2643 3.51258 GeneID:23446,Genbank:NM_001330731.1,HGNC:HGNC:18798,MIM:606105 solute carrier family 44 member 1 GO:0005654,GO:0005739,GO:0005741,GO:0005886,GO:0006656,GO:0015220,GO:0015871,GO:0016020,GO:0016021,GO:0042426,GO:0055085,GO:0070062 nucleoplasm|mitochondrion|mitochondrial outer membrane|plasma membrane|phosphatidylcholine biosynthetic process|choline transmembrane transporter activity|choline transport|membrane|integral component of membrane|choline catabolic process|transmembrane transport|extracellular exosome hsa05231 Choline metabolism in cancer SLC44A2 2501.47344801774 2211.54772979662 2791.39916623887 1.26219259418632 0.335932063631025 0.0161236062731039 0.529251203244782 22.5305 24.0624 30.3641 30.5699 GeneID:57153,Genbank:NM_001145056.1,HGNC:HGNC:17292,MIM:606106 solute carrier family 44 member 2 GO:0004871,GO:0005765,GO:0005886,GO:0006656,GO:0015220,GO:0015871,GO:0016021,GO:0035579,GO:0043123,GO:0043312,GO:0055085,GO:0070062 signal transducer activity|lysosomal membrane|plasma membrane|phosphatidylcholine biosynthetic process|choline transmembrane transporter activity|choline transport|integral component of membrane|specific granule membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|transmembrane transport|extracellular exosome hsa05231 Choline metabolism in cancer SLC44A3 31.1994032550297 26.5402909448516 35.8585155652079 1.3510973048381 0.434131580031614 0.412090426498865 1 0.108207 0.22685 0.258429 0.312616 GeneID:126969,Genbank:NM_001114106.2,HGNC:HGNC:28689 solute carrier family 44 member 3 GO:0005886,GO:0006656,GO:0015220,GO:0016021,GO:0055085 plasma membrane|phosphatidylcholine biosynthetic process|choline transmembrane transporter activity|integral component of membrane|transmembrane transport hsa05231 Choline metabolism in cancer SLC44A4 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0303369 0 0 GeneID:80736,Genbank:NM_001178044.1,HGNC:HGNC:13941,MIM:606107 solute carrier family 44 member 4 GO:0005886,GO:0006656,GO:0008292,GO:0015220,GO:0015871,GO:0016021,GO:0016324,GO:0030307,GO:0030974,GO:0032475,GO:0035675,GO:0055085,GO:0061526,GO:0070062,GO:0090422 plasma membrane|phosphatidylcholine biosynthetic process|acetylcholine biosynthetic process|choline transmembrane transporter activity|choline transport|integral component of membrane|apical plasma membrane|positive regulation of cell growth|thiamine pyrophosphate transmembrane transport|otolith formation|neuromast hair cell development|transmembrane transport|acetylcholine secretion|extracellular exosome|thiamine pyrophosphate transmembrane transporter activity hsa05231 Choline metabolism in cancer SLC44A5 160.974022301356 193.516300839946 128.431743762765 0.663674032654173 -0.591453267385482 0.0774970277505184 0.94157495521624 0.903537 0.696964 0.527993 0.472822 GeneID:204962,Genbank:NM_001130058.1,HGNC:HGNC:28524 solute carrier family 44 member 5 GO:0005886,GO:0006656,GO:0015220,GO:0016021,GO:0055085 plasma membrane|phosphatidylcholine biosynthetic process|choline transmembrane transporter activity|integral component of membrane|transmembrane transport hsa05231 Choline metabolism in cancer SLC45A1 81.6514342448084 74.6241062656112 88.6787622240056 1.18833935388612 0.248946885176322 0.460955785420105 1 1.3566 1.22463 1.27781 1.75255 GeneID:50651,Genbank:NM_001080397.2,HGNC:HGNC:17939,MIM:605763 solute carrier family 45 member 1 GO:0015293,GO:0016021,GO:1904659 symporter activity|integral component of membrane|glucose transmembrane transport SLC45A2 3.3195367380373 4.69880026572591 1.94027321034868 0.412929492768923 -1.27603263071589 0.518133599179378 1 0.0724235 0.0268474 0.055194 0 GeneID:51151,Genbank:NM_016180.4,HGNC:HGNC:16472,MIM:606202 solute carrier family 45 member 2 SLC45A3 242.111972995985 275.847279367928 208.376666624042 0.755405915554115 -0.404676013376724 0.0597857268435945 0.879410748501007 4.43591 4.10867 3.05171 3.36923 GeneID:85414,Genbank:NM_033102.2,HGNC:HGNC:8642,MIM:605097 solute carrier family 45 member 3 GO:0005886,GO:0008506,GO:0008645,GO:0010907,GO:0015770,GO:0016021,GO:0045723,GO:0048713,GO:0051119 plasma membrane|sucrose:proton symporter activity|hexose transport|positive regulation of glucose metabolic process|sucrose transport|integral component of membrane|positive regulation of fatty acid biosynthetic process|regulation of oligodendrocyte differentiation|sugar transmembrane transporter activity hsa05202,hsa05206 Transcriptional misregulation in cancer|MicroRNAs in cancer SLC45A4 360.250451205665 328.918052602523 391.582849808808 1.19051796248475 0.25158938809432 0.180700233375215 1 1.00174 0.902975 1.24491 1.17611 GeneID:57210,Genbank:NM_001286646.1,HGNC:HGNC:29196 solute carrier family 45 member 4 GO:0008506,GO:0015770,GO:0016021 sucrose:proton symporter activity|sucrose transport|integral component of membrane SLC46A1 708.957308336125 727.82026313558 690.09435353667 0.94816589821726 -0.0767885889329155 0.619511284643272 1 3.9878 4.49915 3.98767 4.04365 GeneID:113235,Genbank:NM_001242366.2,HGNC:HGNC:30521,MIM:611672 solute carrier family 46 member 1 hsa01523,hsa04977,hsa04978 Antifolate resistance|Vitamin digestion and absorption|Mineral absorption SLC46A3 257.734173250985 203.807800281051 311.66054622092 1.5291885089341 0.612766264214004 0.0382153341609575 0.74641072185597 3.35983 2.76576 5.51684 3.79651 GeneID:283537,Genbank:NM_001347960.1,HGNC:HGNC:27501,MIM:616764 solute carrier family 46 member 3 GO:0016021,GO:0055085,GO:0070062 integral component of membrane|transmembrane transport|extracellular exosome SLC47A1 234.759012522409 216.059585329985 253.458439714833 1.17309509470607 0.230319967415938 0.279785948730839 1 3.52677 3.08758 3.84491 3.82529 GeneID:55244,Genbank:NM_018242.2,HGNC:HGNC:25588,MIM:609832 solute carrier family 47 member 1 GO:0005451,GO:0005886,GO:0006855,GO:0015238,GO:0015307,GO:0015695,GO:0016021,GO:0031982,GO:0055085 monovalent cation:proton antiporter activity|plasma membrane|drug transmembrane transport|drug transmembrane transporter activity|drug:proton antiporter activity|organic cation transport|integral component of membrane|vesicle|transmembrane transport SLC47A2 1.97048603866634 1.51824048055703 2.42273159677566 1.5957495718246 0.674234260686317 0.891305871991378 1 0.0101158 0.00904393 0 0.0266307 GeneID:146802,Genbank:XM_017024221.1,HGNC:HGNC:26439,MIM:609833 solute carrier family 47 member 2 GO:0005886,GO:0006855,GO:0015238,GO:0015307,GO:0016021,GO:0055085 plasma membrane|drug transmembrane transport|drug transmembrane transporter activity|drug:proton antiporter activity|integral component of membrane|transmembrane transport SLC48A1 619.517389412795 631.335048880627 607.699729944962 0.962562954523797 -0.0550471944946622 0.738273644472377 1 4.87334 5.13513 4.79204 5.00163 GeneID:55652,Genbank:XM_024449045.1,HGNC:HGNC:26035,MIM:612187 solute carrier family 48 member 1 GO:0005765,GO:0005886,GO:0010008,GO:0015232,GO:0015886,GO:0016021,GO:0020037 lysosomal membrane|plasma membrane|endosome membrane|heme transporter activity|heme transport|integral component of membrane|heme binding SLC49A3 13.2186882479739 12.3860552178809 14.0513212780668 1.13444684614209 0.181989013943087 0.85480594952482 1 0.0373368 0.0404142 0.0518852 0.064783 GeneID:84179,Genbank:XM_024454250.1,HGNC:HGNC:26177 solute carrier family 49 member 3 GO:0016021,GO:0055085 integral component of membrane|transmembrane transport SLC4A10 3.2357511831627 2.59443583384164 3.87706653248377 1.49437749891965 0.579544637434413 0.813496720250352 1 0.0179583 0.0115866 0.023128 0.016125 GeneID:57282,Genbank:XM_024453017.1,HGNC:HGNC:13811,MIM:605556 solute carrier family 4 member 10 GO:0005452,GO:0005886,GO:0005887,GO:0006821,GO:0007399,GO:0008510,GO:0009416,GO:0009791,GO:0015301,GO:0015701,GO:0016021,GO:0016323,GO:0021860,GO:0035264,GO:0035641,GO:0043025,GO:0048854,GO:0051453,GO:0097440,GO:0097441,GO:0097442,GO:1902600 inorganic anion exchanger activity|plasma membrane|integral component of plasma membrane|chloride transport|nervous system development|sodium:bicarbonate symporter activity|response to light stimulus|post-embryonic development|anion:anion antiporter activity|bicarbonate transport|integral component of membrane|basolateral plasma membrane|pyramidal neuron development|multicellular organism growth|locomotory exploration behavior|neuronal cell body|brain morphogenesis|regulation of intracellular pH|apical dendrite|basal dendrite|CA3 pyramidal cell dendrite|hydrogen ion transmembrane transport SLC4A11 105.10896990924 97.2918522694888 112.92608754899 1.16069418882268 0.214987911579093 0.474272457332068 1 0.593325 0.655277 0.825756 0.635139 GeneID:83959,Genbank:NM_001174089.1,HGNC:HGNC:16438,MIM:610206 solute carrier family 4 member 11 GO:0005272,GO:0005452,GO:0005887,GO:0006814,GO:0015106,GO:0015252,GO:0015293,GO:0015301,GO:0015701,GO:0015992,GO:0016323,GO:0030003,GO:0042044,GO:0046713,GO:0046715,GO:0046983,GO:0051453 sodium channel activity|inorganic anion exchanger activity|integral component of plasma membrane|sodium ion transport|bicarbonate transmembrane transporter activity|proton channel activity|symporter activity|anion:anion antiporter activity|bicarbonate transport|proton transport|basolateral plasma membrane|cellular cation homeostasis|fluid transport|borate transport|active borate transmembrane transporter activity|protein dimerization activity|regulation of intracellular pH SLC4A1AP 753.359294852587 788.999702138532 717.718887566643 0.909656728160117 -0.136605868270085 0.405627947919264 1 7.81257 7.3267 6.86958 6.83462 GeneID:22950,Genbank:NM_018158.2,HGNC:HGNC:13813,MIM:602655 solute carrier family 4 member 1 adaptor protein SLC4A2 12419.4402279483 12038.7952634117 12800.0851924849 1.06323638806177 0.0884623851762418 0.511141539909722 1 81.9609 84.6177 89.0224 92.2874 GeneID:6522,Genbank:NM_001199692.2,HGNC:HGNC:11028,MIM:109280 solute carrier family 4 member 2 hsa04970,hsa04971,hsa04972,hsa04976 Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion SLC4A3 233.287778842811 221.864006914319 244.711550771303 1.10297994782816 0.14140656297659 0.541734037048038 1 1.34456 1.529 1.39821 1.70303 GeneID:6508,Genbank:NM_001326559.1,HGNC:HGNC:11029,MIM:106195 solute carrier family 4 member 3 GO:0005452,GO:0005886,GO:0005887,GO:0006810,GO:0008510,GO:0015301,GO:0015701,GO:0016020,GO:0051453 inorganic anion exchanger activity|plasma membrane|integral component of plasma membrane|transport|sodium:bicarbonate symporter activity|anion:anion antiporter activity|bicarbonate transport|membrane|regulation of intracellular pH SLC4A4 36.357276467837 29.5669632508577 43.1475896848164 1.45931759439532 0.545293894220086 0.467887616272322 1 0.101006 0.0711075 0.155739 0.0754508 GeneID:8671,Genbank:XM_024454269.1,HGNC:HGNC:11030,MIM:603345 solute carrier family 4 member 4 GO:0005452,GO:0005886,GO:0005887,GO:0006810,GO:0006814,GO:0008510,GO:0015701,GO:0016323,GO:0042802,GO:0051453,GO:0070062 inorganic anion exchanger activity|plasma membrane|integral component of plasma membrane|transport|sodium ion transport|sodium:bicarbonate symporter activity|bicarbonate transport|basolateral plasma membrane|identical protein binding|regulation of intracellular pH|extracellular exosome hsa04964,hsa04972,hsa04976 Proximal tubule bicarbonate reclamation|Pancreatic secretion|Bile secretion SLC4A5 9.47309401930321 9.253521707397 9.69266633120943 1.04745702638395 0.0668910562448926 1 1 0.0428696 0.0338726 0.0464532 0.0541332 GeneID:57835,Genbank:NM_133478.2,HGNC:HGNC:18168,MIM:606757 solute carrier family 4 member 5 GO:0002064,GO:0003014,GO:0003073,GO:0005452,GO:0005886,GO:0005887,GO:0008510,GO:0010468,GO:0015301,GO:0015701,GO:0016021,GO:0016324,GO:0033326,GO:0048311,GO:0051453,GO:0060041 epithelial cell development|renal system process|regulation of systemic arterial blood pressure|inorganic anion exchanger activity|plasma membrane|integral component of plasma membrane|sodium:bicarbonate symporter activity|regulation of gene expression|anion:anion antiporter activity|bicarbonate transport|integral component of membrane|apical plasma membrane|cerebrospinal fluid secretion|mitochondrion distribution|regulation of intracellular pH|retina development in camera-type eye hsa04976 Bile secretion SLC4A7 934.258125872004 957.703640921429 910.81261082258 0.951038058022068 -0.0724250198150993 0.884477618029809 1 5.33552 4.16762 5.78737 3.41252 GeneID:9497,Genbank:XM_017007527.2,HGNC:HGNC:11033,MIM:603353 solute carrier family 4 member 7 GO:0005452,GO:0005886,GO:0005887,GO:0008510,GO:0015701,GO:0016021,GO:0016323,GO:0016324,GO:0031410,GO:0032420,GO:0045202,GO:0051453,GO:0060117 inorganic anion exchanger activity|plasma membrane|integral component of plasma membrane|sodium:bicarbonate symporter activity|bicarbonate transport|integral component of membrane|basolateral plasma membrane|apical plasma membrane|cytoplasmic vesicle|stereocilium|synapse|regulation of intracellular pH|auditory receptor cell development SLC4A8 860.264378806215 765.602770360127 954.925987252303 1.24728648356787 0.318792869300352 0.403416192912908 1 1.71155 1.80952 2.85925 1.64856 GeneID:9498,Genbank:XM_011539011.1,HGNC:HGNC:11034,MIM:605024 solute carrier family 4 member 8 GO:0005452,GO:0005886,GO:0005887,GO:0008510,GO:0015301,GO:0015701,GO:0032809,GO:0043005,GO:0051453 inorganic anion exchanger activity|plasma membrane|integral component of plasma membrane|sodium:bicarbonate symporter activity|anion:anion antiporter activity|bicarbonate transport|neuronal cell body membrane|neuron projection|regulation of intracellular pH SLC4A9 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0 0 0 GeneID:83697,Genbank:XM_017009933.1,HGNC:HGNC:11035,MIM:610207 solute carrier family 4 member 9 GO:0005452,GO:0005886,GO:0005887,GO:0008510,GO:0015301,GO:0015701,GO:0045177,GO:0051453 inorganic anion exchanger activity|plasma membrane|integral component of plasma membrane|sodium:bicarbonate symporter activity|anion:anion antiporter activity|bicarbonate transport|apical part of cell|regulation of intracellular pH SLC50A1 980.087592880468 914.821556926025 1045.35362883491 1.14268582864127 0.192428801833636 0.210514472601872 1 16.7059 17.1961 20.1682 19.445 GeneID:55974,Genbank:NM_001287590.1,HGNC:HGNC:30657,MIM:613683 solute carrier family 50 member 1 GO:0000139,GO:0005634,GO:0005794,GO:0005886,GO:0008643,GO:0008645,GO:0012505,GO:0016021,GO:0042947,GO:0045815,GO:0051119 Golgi membrane|nucleus|Golgi apparatus|plasma membrane|carbohydrate transport|hexose transport|endomembrane system|integral component of membrane|glucoside transmembrane transporter activity|positive regulation of gene expression, epigenetic|sugar transmembrane transporter activity SLC51A 3.02310324063518 3.6226049124413 2.42360156882906 0.669021775050752 -0.579874927000458 0.839804273845197 1 0 0.0325475 0.0339679 0 GeneID:200931,Genbank:NM_152672.5,HGNC:HGNC:29955,MIM:612084 solute carrier family 51 alpha subunit GO:0005789,GO:0005886,GO:0015125,GO:0015721,GO:0016021,GO:0016323,GO:0032782,GO:0042803,GO:0043234,GO:0046982 endoplasmic reticulum membrane|plasma membrane|bile acid transmembrane transporter activity|bile acid and bile salt transport|integral component of membrane|basolateral plasma membrane|bile acid secretion|protein homodimerization activity|protein complex|protein heterodimerization activity hsa04976 Bile secretion SLC51B 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0291493 0 0 GeneID:123264,Genbank:NM_178859.3,HGNC:HGNC:29956,MIM:612085 solute carrier family 51 beta subunit GO:0005886,GO:0015125,GO:0015721,GO:0016021,GO:0016323,GO:0031647,GO:0032782,GO:0043234,GO:0046982,GO:0060050,GO:0070863,GO:0090314 plasma membrane|bile acid transmembrane transporter activity|bile acid and bile salt transport|integral component of membrane|basolateral plasma membrane|regulation of protein stability|bile acid secretion|protein complex|protein heterodimerization activity|positive regulation of protein glycosylation|positive regulation of protein exit from endoplasmic reticulum|positive regulation of protein targeting to membrane hsa04976 Bile secretion SLC52A1 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0.0263113 0.0227709 0 0 GeneID:55065,Genbank:NM_017986.3,HGNC:HGNC:30225,MIM:607883 solute carrier family 52 member 1 GO:0001618,GO:0005886,GO:0005887,GO:0006771,GO:0032217,GO:0032218 virus receptor activity|plasma membrane|integral component of plasma membrane|riboflavin metabolic process|riboflavin transmembrane transporter activity|riboflavin transport SLC52A2 1538.22954103965 1540.22975671019 1536.22932536912 0.997402704808394 -0.00375197950377976 0.951044196396345 1 38.5395 41.7273 40.6318 41.8519 GeneID:79581,Genbank:XM_017013822.1,HGNC:HGNC:30224,MIM:607882 solute carrier family 52 member 2 GO:0001618,GO:0005886,GO:0005887,GO:0006771,GO:0032217,GO:0032218 virus receptor activity|plasma membrane|integral component of plasma membrane|riboflavin metabolic process|riboflavin transmembrane transporter activity|riboflavin transport SLC52A3 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0141864 0 GeneID:113278,Genbank:XM_005260655.4,HGNC:HGNC:16187,MIM:613350 solute carrier family 52 member 3 GO:0005886,GO:0005887,GO:0006771,GO:0007605,GO:0016324,GO:0032217,GO:0032218,GO:0034605 plasma membrane|integral component of plasma membrane|riboflavin metabolic process|sensory perception of sound|apical plasma membrane|riboflavin transmembrane transporter activity|riboflavin transport|cellular response to heat hsa04977 Vitamin digestion and absorption SLC5A1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00769673 0 0 GeneID:6523,Genbank:NM_000343.3,HGNC:HGNC:11036,MIM:182380 solute carrier family 5 member 1 GO:0001951,GO:0005412,GO:0005886,GO:0005887,GO:0015758,GO:0070062,GO:0106001 intestinal D-glucose absorption|glucose:sodium symporter activity|plasma membrane|integral component of plasma membrane|glucose transport|extracellular exosome|intestinal hexose absorption hsa04973,hsa04976,hsa04978 Carbohydrate digestion and absorption|Bile secretion|Mineral absorption SLC5A10 18.7759211470756 18.1708594919994 19.3809828021519 1.06659692188393 0.0930150696334471 0.959978835250681 1 0.0225385 0.0192599 0.0415752 0.0193934 GeneID:125206,Genbank:NM_001282417.1,HGNC:HGNC:23155 solute carrier family 5 member 10 GO:0005412,GO:0005886,GO:0005887,GO:0006814,GO:0008645,GO:0015370,GO:0070062,GO:1904659 glucose:sodium symporter activity|plasma membrane|integral component of plasma membrane|sodium ion transport|hexose transport|solute:sodium symporter activity|extracellular exosome|glucose transmembrane transport SLC5A11 0.995346334121811 0.538097676642304 1.45259499160132 2.69950058261805 1.43269252815597 0.83528100889094 1 0.0143246 0 0 0 GeneID:115584,Genbank:NM_001352235.1,HGNC:HGNC:23091,MIM:610238 solute carrier family 5 member 11 GO:0005412,GO:0005886,GO:0005887,GO:0006814,GO:0006915,GO:0015166,GO:0015798,GO:1904659 glucose:sodium symporter activity|plasma membrane|integral component of plasma membrane|sodium ion transport|apoptotic process|polyol transmembrane transporter activity|myo-inositol transport|glucose transmembrane transport SLC5A12 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.010532 0 0 0 GeneID:159963,Genbank:NM_178498.3,HGNC:HGNC:28750,MIM:612455 solute carrier family 5 member 12 GO:0005343,GO:0005886,GO:0006811,GO:0015129,GO:0016021,GO:0016324,GO:0070062 organic acid:sodium symporter activity|plasma membrane|ion transport|lactate transmembrane transporter activity|integral component of membrane|apical plasma membrane|extracellular exosome SLC5A2 32.5783434747027 37.052304449165 28.1043825002404 0.758505656208212 -0.398768156138043 0.586480331611849 1 0.4309 0.197694 0.191106 0.32054 GeneID:6524,Genbank:XM_006721072.4,HGNC:HGNC:11037,MIM:182381 solute carrier family 5 member 2 GO:0005362,GO:0005412,GO:0005886,GO:0005887,GO:0005975,GO:0006810,GO:0008645,GO:0016021,GO:0070062 low-affinity glucose:sodium symporter activity|glucose:sodium symporter activity|plasma membrane|integral component of plasma membrane|carbohydrate metabolic process|transport|hexose transport|integral component of membrane|extracellular exosome SLC5A3 978.882304441752 892.805544456666 1064.95906442684 1.19282308565292 0.254380084627597 0.499059548494084 1 3.94186 3.5605 5.73478 3.36567 GeneID:6526,Genbank:NM_006933.6,HGNC:HGNC:11038,MIM:600444 solute carrier family 5 member 3 GO:0005367,GO:0005886,GO:0005887,GO:0006020,GO:0006810,GO:0007422,GO:0015293,GO:0015798,GO:0016021,GO:0043576 myo-inositol:sodium symporter activity|plasma membrane|integral component of plasma membrane|inositol metabolic process|transport|peripheral nervous system development|symporter activity|myo-inositol transport|integral component of membrane|regulation of respiratory gaseous exchange SLC5A6 1058.22743841787 1109.40424446415 1007.05063237159 0.907740021184078 -0.139648929368765 0.366135886252257 1 14.1747 12.2518 12.3049 11.8504 GeneID:8884,Genbank:XM_024453207.1,HGNC:HGNC:11041,MIM:604024 solute carrier family 5 member 6 GO:0005886,GO:0005887,GO:0006768,GO:0006810,GO:0008523,GO:0012506,GO:0015878,GO:0015887,GO:0015939,GO:0016020,GO:0031526,GO:0055085 plasma membrane|integral component of plasma membrane|biotin metabolic process|transport|sodium-dependent multivitamin transmembrane transporter activity|vesicle membrane|biotin transport|pantothenate transmembrane transport|pantothenate metabolic process|membrane|brush border membrane|transmembrane transport hsa04977 Vitamin digestion and absorption SLC6A12 5.26557465333447 6.169014471598 4.36213483507094 0.707104004238296 -0.50000566576003 0.763424179975903 1 0.0294609 0.0529291 0.0184906 0.0172321 GeneID:6539,Genbank:NM_001206931.1,HGNC:HGNC:11045,MIM:603080 solute carrier family 6 member 12 GO:0005215,GO:0005332,GO:0005886,GO:0005887,GO:0006810,GO:0006865,GO:0015171,GO:0016021 transporter activity|gamma-aminobutyric acid:sodium symporter activity|plasma membrane|integral component of plasma membrane|transport|amino acid transport|amino acid transmembrane transporter activity|integral component of membrane SLC6A13 1.0016543915721 1.51824048055703 0.48506830258717 0.319493722370782 -1.64614051048666 0.791481013618379 1 0 0.0208537 0 0 GeneID:6540,Genbank:NM_001190997.2,HGNC:HGNC:11046,MIM:615097 solute carrier family 6 member 13 GO:0005215,GO:0005332,GO:0005886,GO:0005887,GO:0070062 transporter activity|gamma-aminobutyric acid:sodium symporter activity|plasma membrane|integral component of plasma membrane|extracellular exosome hsa04727 GABAergic synapse SLC6A15 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0.00644324 0.00635491 0 0.0058312 GeneID:55117,Genbank:NM_001146335.2,HGNC:HGNC:13621,MIM:607971 solute carrier family 6 member 15 GO:0005298,GO:0005326,GO:0005328,GO:0005886,GO:0005887,GO:0006836,GO:0006865,GO:0015171,GO:0015804,GO:0015820,GO:0015824,GO:0016021 proline:sodium symporter activity|neurotransmitter transporter activity|neurotransmitter:sodium symporter activity|plasma membrane|integral component of plasma membrane|neurotransmitter transport|amino acid transport|amino acid transmembrane transporter activity|neutral amino acid transport|leucine transport|proline transport|integral component of membrane SLC6A16 28.208894911137 24.9161892598167 31.5016005624573 1.26430250765759 0.338341696174633 0.522754555239695 1 0.12887 0.0749441 0.121868 0.0619051 GeneID:28968,Genbank:XM_011526859.3,HGNC:HGNC:13622,MIM:607972 solute carrier family 6 member 16 GO:0005326,GO:0005328,GO:0005622,GO:0005887,GO:0006836,GO:0015171 neurotransmitter transporter activity|neurotransmitter:sodium symporter activity|intracellular|integral component of plasma membrane|neurotransmitter transport|amino acid transmembrane transporter activity SLC6A17 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.00692372 0.0061053 0 0 GeneID:388662,Genbank:NM_001010898.3,HGNC:HGNC:31399,MIM:610299 solute carrier family 6 member 17 GO:0005328,GO:0005887,GO:0007420,GO:0008021,GO:0015171,GO:0015804,GO:0015816,GO:0015820,GO:0015824,GO:0030054,GO:0030672,GO:0032328 neurotransmitter:sodium symporter activity|integral component of plasma membrane|brain development|synaptic vesicle|amino acid transmembrane transporter activity|neutral amino acid transport|glycine transport|leucine transport|proline transport|cell junction|synaptic vesicle membrane|alanine transport SLC6A20 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0.00723288 0 0 0 GeneID:54716,Genbank:NM_022405.3,HGNC:HGNC:30927,MIM:605616 solute carrier family 6 member 20 GO:0005328,GO:0005886,GO:0005887,GO:0006865,GO:0015171,GO:0015193,GO:0015816,GO:0015824,GO:0015838,GO:0016324 neurotransmitter:sodium symporter activity|plasma membrane|integral component of plasma membrane|amino acid transport|amino acid transmembrane transporter activity|L-proline transmembrane transporter activity|glycine transport|proline transport|amino-acid betaine transport|apical plasma membrane SLC6A3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0124843 0 0 0 GeneID:6531,Genbank:NM_001044.4,HGNC:HGNC:11049,MIM:126455 solute carrier family 6 member 3 hsa04728,hsa05012,hsa05030,hsa05031,hsa05034 Dopaminergic synapse|Parkinson disease|Cocaine addiction|Amphetamine addiction|Alcoholism SLC6A4 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0.00685768 0 0 0.0122002 GeneID:6532,Genbank:NM_001045.5,HGNC:HGNC:11050,MIM:182138 solute carrier family 6 member 4 hsa04726 Serotonergic synapse SLC6A6 7191.14683698084 6828.54166642557 7553.75200753611 1.10620281409078 0.145615917271022 0.273650749308467 1 32.1936 33.8292 37.0402 36.9699 GeneID:6533,Genbank:NM_003043.5,HGNC:HGNC:11052,MIM:186854 solute carrier family 6 member 6 GO:0003333,GO:0005328,GO:0005369,GO:0005886,GO:0005887,GO:0006520,GO:0006810,GO:0006865,GO:0015171,GO:0015734,GO:0016021 amino acid transmembrane transport|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity|plasma membrane|integral component of plasma membrane|cellular amino acid metabolic process|transport|amino acid transport|amino acid transmembrane transporter activity|taurine transport|integral component of membrane SLC6A8 1781.83059109779 1414.89797332465 2148.76320887094 1.51867007330704 0.6028084825437 2.65793537006097e-05 0.00965905128657166 16.6893 17.6315 26.2079 27.2168 GeneID:6535,Genbank:NM_005629.3,HGNC:HGNC:11055,MIM:300036 solute carrier family 6 member 8 GO:0005308,GO:0005309,GO:0005328,GO:0005886,GO:0005887,GO:0006600,GO:0006810,GO:0006936,GO:0015881,GO:0016021 creatine transmembrane transporter activity|creatine:sodium symporter activity|neurotransmitter:sodium symporter activity|plasma membrane|integral component of plasma membrane|creatine metabolic process|transport|muscle contraction|creatine transport|integral component of membrane SLC6A9 790.020024591227 792.048025756463 787.992023425992 0.99487909546066 -0.00740688478661824 0.932186787881501 1 6.69757 8.18164 7.30339 7.38655 GeneID:6536,Genbank:NM_001328630.1,HGNC:HGNC:11056,MIM:601019 solute carrier family 6 member 9 GO:0005215,GO:0005886,GO:0005887,GO:0006810,GO:0015375,GO:0016020,GO:0061537,GO:0098793 transporter activity|plasma membrane|integral component of plasma membrane|transport|glycine:sodium symporter activity|membrane|glycine secretion, neurotransmission|presynapse SLC7A1 4810.06851883145 4501.72231296535 5118.41472469755 1.13699032700353 0.185219980489263 0.164497700451364 1 25.8651 25.4178 31.733 27.1728 GeneID:6541,Genbank:XM_017020713.2,HGNC:HGNC:11057,MIM:104615 solute carrier family 7 member 1 GO:0005886,GO:0005887,GO:0006810,GO:0006865,GO:0015171,GO:0015181,GO:0016020 plasma membrane|integral component of plasma membrane|transport|amino acid transport|amino acid transmembrane transporter activity|arginine transmembrane transporter activity|membrane hsa05206 MicroRNAs in cancer SLC7A11 951.239887383059 1034.89479105727 867.584983708851 0.838331578442394 -0.25440712070042 0.214128647252552 1 5.05053 4.54432 4.60628 3.36802 GeneID:23657,Genbank:NM_014331.3,HGNC:HGNC:11059,MIM:607933 solute carrier family 7 member 11 GO:0005791,GO:0005856,GO:0005886,GO:0005887,GO:0006865,GO:0006979,GO:0007420,GO:0009636,GO:0009986,GO:0015327,GO:0016021,GO:0035094,GO:0050900,GO:0070306,GO:0070527 rough endoplasmic reticulum|cytoskeleton|plasma membrane|integral component of plasma membrane|amino acid transport|response to oxidative stress|brain development|response to toxic substance|cell surface|cystine:glutamate antiporter activity|integral component of membrane|response to nicotine|leukocyte migration|lens fiber cell differentiation|platelet aggregation hsa04216 Ferroptosis SLC7A2 234.466404993373 214.935363702015 253.997446284731 1.18173874187065 0.240911120567309 0.49081784071239 1 1.23323 1.17207 1.76494 1.05249 GeneID:6542,Genbank:XM_017013746.1,HGNC:HGNC:11060,MIM:601872 solute carrier family 7 member 2 GO:0002537,GO:0005289,GO:0005292,GO:0005886,GO:0005887,GO:0006520,GO:0006809,GO:0006810,GO:0006865,GO:0015171,GO:0015174,GO:0016020,GO:0030054,GO:0042116,GO:0043030,GO:0050727,GO:0097626,GO:0097627,GO:0097638,GO:0097639,GO:0097640 nitric oxide production involved in inflammatory response|high-affinity arginine transmembrane transporter activity|high-affinity lysine transmembrane transporter activity|plasma membrane|integral component of plasma membrane|cellular amino acid metabolic process|nitric oxide biosynthetic process|transport|amino acid transport|amino acid transmembrane transporter activity|basic amino acid transmembrane transporter activity|membrane|cell junction|macrophage activation|regulation of macrophage activation|regulation of inflammatory response|low-affinity L-arginine transmembrane transporter activity|high-affinity L-ornithine transmembrane transporter activity|L-arginine import across plasma membrane|L-lysine import across plasma membrane|L-ornithine import across plasma membrane SLC7A5 8773.93174836303 8946.6339052758 8601.22959145027 0.961392819077815 -0.0568020672795747 0.762166940654615 1 69.9208 73.0302 63.4589 76.3706 GeneID:8140,Genbank:NM_003486.6,HGNC:HGNC:11063,MIM:600182 solute carrier family 7 member 5 GO:0005829,GO:0005886,GO:0005887,GO:0006520,GO:0006810,GO:0007399,GO:0015171,GO:0015175,GO:0015179,GO:0015297,GO:0015804,GO:0016020,GO:0016324,GO:0030154,GO:0042605,GO:0043231,GO:0050900,GO:0070062,GO:1902475 cytosol|plasma membrane|integral component of plasma membrane|cellular amino acid metabolic process|transport|nervous system development|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|antiporter activity|neutral amino acid transport|membrane|apical plasma membrane|cell differentiation|peptide antigen binding|intracellular membrane-bounded organelle|leukocyte migration|extracellular exosome|L-alpha-amino acid transmembrane transport hsa04150,hsa05230 mTOR signaling pathway|Central carbon metabolism in cancer SLC7A6 2120.30596887321 2020.34446479495 2220.26747295148 1.09895491171939 0.136132196138604 0.331785263502259 1 12.8893 13.0361 16.4329 12.8571 GeneID:9057,Genbank:XM_011523438.2,HGNC:HGNC:11064,MIM:605641 solute carrier family 7 member 6 GO:0005886,GO:0005887,GO:0006461,GO:0006520,GO:0006810,GO:0006865,GO:0015171,GO:0015179,GO:0015297,GO:0016323,GO:0043231,GO:0050900 plasma membrane|integral component of plasma membrane|protein complex assembly|cellular amino acid metabolic process|transport|amino acid transport|amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|antiporter activity|basolateral plasma membrane|intracellular membrane-bounded organelle|leukocyte migration SLC7A6OS 408.886402070976 394.702273323541 423.070530818411 1.07187254650448 0.100133368988193 0.600231315203218 1 5.65772 6.2865 6.42657 6.66628 GeneID:84138,Genbank:NM_032178.2,HGNC:HGNC:25807 solute carrier family 7 member 6 opposite strand GO:0002244,GO:0005634,GO:0005737,GO:0015031 hematopoietic progenitor cell differentiation|nucleus|cytoplasm|protein transport SLC7A7 3.7792869452019 4.65077399104097 2.90779989936283 0.625229242479698 -0.677542838952464 0.741128216879478 1 0.116434 0.0637564 0.0660011 0.0615231 GeneID:9056,Genbank:NM_001126106.2,HGNC:HGNC:11065,MIM:603593 solute carrier family 7 member 7 GO:0000821,GO:0005886,GO:0005887,GO:0006461,GO:0006520,GO:0006810,GO:0006865,GO:0015174,GO:0015179,GO:0015297,GO:0016323,GO:0050900 regulation of arginine metabolic process|plasma membrane|integral component of plasma membrane|protein complex assembly|cellular amino acid metabolic process|transport|amino acid transport|basic amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|antiporter activity|basolateral plasma membrane|leukocyte migration hsa04974 Protein digestion and absorption SLC7A8 9.19436560179328 7.24520982488261 11.143521378704 1.53805364482795 0.621105823051079 0.538602343627343 1 0.0719977 0.0484348 0.0505732 0.10254 GeneID:23428,Genbank:NM_012244.3,HGNC:HGNC:11066,MIM:604235 solute carrier family 7 member 8 GO:0005737,GO:0005886,GO:0005887,GO:0006520,GO:0006810,GO:0006865,GO:0009636,GO:0015101,GO:0015171,GO:0015175,GO:0015179,GO:0015297,GO:0015804,GO:0016323,GO:0019534,GO:0042605,GO:0050900,GO:0055065,GO:0070062 cytoplasm|plasma membrane|integral component of plasma membrane|cellular amino acid metabolic process|transport|amino acid transport|response to toxic substance|organic cation transmembrane transporter activity|amino acid transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|antiporter activity|neutral amino acid transport|basolateral plasma membrane|toxin transmembrane transporter activity|peptide antigen binding|leukocyte migration|metal ion homeostasis|extracellular exosome hsa04974 Protein digestion and absorption SLC7A9 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:11136,Genbank:XM_011526402.3,HGNC:HGNC:11067,MIM:604144 solute carrier family 7 member 9 GO:0005886,GO:0005887,GO:0006461,GO:0006865,GO:0015175,GO:0015184,GO:0015297,GO:0015804,GO:0015811,GO:0016324,GO:0031526,GO:0042605,GO:0050900 plasma membrane|integral component of plasma membrane|protein complex assembly|amino acid transport|neutral amino acid transmembrane transporter activity|L-cystine transmembrane transporter activity|antiporter activity|neutral amino acid transport|L-cystine transport|apical plasma membrane|brush border membrane|peptide antigen binding|leukocyte migration hsa04974 Protein digestion and absorption SLC8A1 56.1936091583136 41.616834545944 70.7703837706832 1.70052298649851 0.765978507535479 0.0641208214286732 0.90091963811897 0.178323 0.164552 0.39341 0.210897 GeneID:6546,Genbank:XM_006712083.4,HGNC:HGNC:11068,MIM:182305 solute carrier family 8 member A1 GO:0002026,GO:0002027,GO:0002028,GO:0005432,GO:0005509,GO:0005516,GO:0005654,GO:0005739,GO:0005874,GO:0005886,GO:0005887,GO:0006811,GO:0006883,GO:0006936,GO:0008092,GO:0009749,GO:0010649,GO:0010763,GO:0010881,GO:0010882,GO:0014704,GO:0014829,GO:0021537,GO:0030018,GO:0030315,GO:0030501,GO:0030506,GO:0033198,GO:0034614,GO:0035725,GO:0035902,GO:0035994,GO:0042383,GO:0042542,GO:0043197,GO:0043198,GO:0044325,GO:0044557,GO:0045211,GO:0051481,GO:0055013,GO:0055074,GO:0055119,GO:0060048,GO:0060401,GO:0060402,GO:0070509,GO:0070588,GO:0071313,GO:0071320,GO:0071436,GO:0071456,GO:0086012,GO:0086064,GO:0097369,GO:0098735,GO:0099580,GO:1901660,GO:1903779 regulation of the force of heart contraction|regulation of heart rate|regulation of sodium ion transport|calcium:sodium antiporter activity|calcium ion binding|calmodulin binding|nucleoplasm|mitochondrion|microtubule|plasma membrane|integral component of plasma membrane|ion transport|cellular sodium ion homeostasis|muscle contraction|cytoskeletal protein binding|response to glucose|regulation of cell communication by electrical coupling|positive regulation of fibroblast migration|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of cardiac muscle contraction by calcium ion signaling|intercalated disc|vascular smooth muscle contraction|telencephalon development|Z disc|T-tubule|positive regulation of bone mineralization|ankyrin binding|response to ATP|cellular response to reactive oxygen species|sodium ion transmembrane transport|response to immobilization stress|response to muscle stretch|sarcolemma|response to hydrogen peroxide|dendritic spine|dendritic shaft|ion channel binding|relaxation of smooth muscle|postsynaptic membrane|negative regulation of cytosolic calcium ion concentration|cardiac muscle cell development|calcium ion homeostasis|relaxation of cardiac muscle|cardiac muscle contraction|cytosolic calcium ion transport|calcium ion transport into cytosol|calcium ion import|calcium ion transmembrane transport|cellular response to caffeine|cellular response to cAMP|sodium ion export|cellular response to hypoxia|membrane depolarization during cardiac muscle cell action potential|cell communication by electrical coupling involved in cardiac conduction|sodium ion import|positive regulation of the force of heart contraction|ion antiporter activity involved in regulation of postsynaptic membrane potential|calcium ion export|regulation of cardiac conduction hsa04020,hsa04022,hsa04260,hsa04261,hsa04371,hsa04740,hsa04961,hsa04974,hsa04978,hsa05410,hsa05412,hsa05414 Calcium signaling pathway|cGMP-PKG signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Olfactory transduction|Endocrine and other factor-regulated calcium reabsorption|Protein digestion and absorption|Mineral absorption|Hypertrophic cardiomyopathy (HCM)|Arrhythmogenic right ventricular cardiomyopathy (ARVC)|Dilated cardiomyopathy (DCM) SLC8A2 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0178487 GeneID:6543,Genbank:XM_005259172.2,HGNC:HGNC:11069,MIM:601901 solute carrier family 8 member A2 GO:0005432,GO:0005516,GO:0005886,GO:0005887,GO:0006811,GO:0006874,GO:0007154,GO:0007612,GO:0007613,GO:0016323,GO:0035725,GO:0043197,GO:0043204,GO:0046872,GO:0048172,GO:0060291,GO:0070588,GO:1903779 calcium:sodium antiporter activity|calmodulin binding|plasma membrane|integral component of plasma membrane|ion transport|cellular calcium ion homeostasis|cell communication|learning|memory|basolateral plasma membrane|sodium ion transmembrane transport|dendritic spine|perikaryon|metal ion binding|regulation of short-term neuronal synaptic plasticity|long-term synaptic potentiation|calcium ion transmembrane transport|regulation of cardiac conduction hsa04020,hsa04022,hsa04371,hsa04740,hsa04974 Calcium signaling pathway|cGMP-PKG signaling pathway|Apelin signaling pathway|Olfactory transduction|Protein digestion and absorption SLC8B1 262.179985272892 260.232638090193 264.12733245559 1.01496620252548 0.0214316877447346 0.924527073395954 1 2.77236 2.63752 2.94814 2.7307 GeneID:80024,Genbank:NM_024959.3,HGNC:HGNC:26175,MIM:609841 solute carrier family 8 member B1 GO:0005432,GO:0005743,GO:0005886,GO:0006811,GO:0006851,GO:0015368,GO:0030061,GO:0032592,GO:0042383,GO:0042593,GO:0042803,GO:0050796,GO:0050896,GO:0051480,GO:0051560,GO:0086036,GO:0086038,GO:0099093,GO:1901623,GO:2001256 calcium:sodium antiporter activity|mitochondrial inner membrane|plasma membrane|ion transport|mitochondrial calcium ion transmembrane transport|calcium:cation antiporter activity|mitochondrial crista|integral component of mitochondrial membrane|sarcolemma|glucose homeostasis|protein homodimerization activity|regulation of insulin secretion|response to stimulus|regulation of cytosolic calcium ion concentration|mitochondrial calcium ion homeostasis|regulation of cardiac muscle cell membrane potential|calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential|mitochondrial calcium release|regulation of lymphocyte chemotaxis|regulation of store-operated calcium entry SLC9A1 789.228146477394 833.596199716652 744.860093238136 0.893550250698507 -0.162379230315613 0.304791558873384 1 6.69534 6.57198 6.02824 5.96057 GeneID:6548,Genbank:NM_003047.4,HGNC:HGNC:11071,MIM:107310 solute carrier family 9 member A1 GO:0005516,GO:0005546,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0005886,GO:0005887,GO:0005925,GO:0006811,GO:0006883,GO:0006885,GO:0009986,GO:0010447,GO:0010613,GO:0010882,GO:0014704,GO:0015299,GO:0015385,GO:0015386,GO:0016021,GO:0016323,GO:0016324,GO:0016477,GO:0030011,GO:0030027,GO:0030214,GO:0030307,GO:0030315,GO:0030346,GO:0030674,GO:0032869,GO:0032947,GO:0035794,GO:0035994,GO:0043065,GO:0043066,GO:0045121,GO:0045760,GO:0045944,GO:0048306,GO:0048471,GO:0051259,GO:0051453,GO:0051492,GO:0051893,GO:0051930,GO:0055007,GO:0070062,GO:0070417,GO:0070886,GO:0070997,GO:0071236,GO:0071257,GO:0071260,GO:0071436,GO:0071456,GO:0071468,GO:0071805,GO:0071872,GO:0086003,GO:0086036,GO:0086040,GO:0086092,GO:0090533,GO:0098719,GO:0098735,GO:1902600,GO:1903281 calmodulin binding|phosphatidylinositol-4,5-bisphosphate binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|focal adhesion|ion transport|cellular sodium ion homeostasis|regulation of pH|cell surface|response to acidic pH|positive regulation of cardiac muscle hypertrophy|regulation of cardiac muscle contraction by calcium ion signaling|intercalated disc|solute:proton antiporter activity|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|basolateral plasma membrane|apical plasma membrane|cell migration|maintenance of cell polarity|lamellipodium|hyaluronan catabolic process|positive regulation of cell growth|T-tubule|protein phosphatase 2B binding|protein binding, bridging|cellular response to insulin stimulus|protein complex scaffold activity|positive regulation of mitochondrial membrane permeability|response to muscle stretch|positive regulation of apoptotic process|negative regulation of apoptotic process|membrane raft|positive regulation of action potential|positive regulation of transcription from RNA polymerase II promoter|calcium-dependent protein binding|perinuclear region of cytoplasm|protein oligomerization|regulation of intracellular pH|regulation of stress fiber assembly|regulation of focal adhesion assembly|regulation of sensory perception of pain|cardiac muscle cell differentiation|extracellular exosome|cellular response to cold|positive regulation of calcineurin-NFAT signaling cascade|neuron death|cellular response to antibiotic|cellular response to electrical stimulus|cellular response to mechanical stimulus|sodium ion export|cellular response to hypoxia|cellular response to acidic pH|potassium ion transmembrane transport|cellular response to epinephrine stimulus|cardiac muscle cell contraction|regulation of cardiac muscle cell membrane potential|sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential|regulation of the force of heart contraction by cardiac conduction|cation-transporting ATPase complex|sodium ion import across plasma membrane|positive regulation of the force of heart contraction|hydrogen ion transmembrane transport|positive regulation of calcium:sodium antiporter activity hsa04024,hsa04260,hsa04261,hsa04371,hsa04810,hsa04919,hsa04970,hsa04971,hsa04972,hsa04976,hsa05205 cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Apelin signaling pathway|Regulation of actin cytoskeleton|Thyroid hormone signaling pathway|Salivary secretion|Gastric acid secretion|Pancreatic secretion|Bile secretion|Proteoglycans in cancer SLC9A2 21.4368388262875 22.5138585247148 20.3598191278602 0.904323845932938 -0.145088588557292 0.916726465499181 1 0.215975 0.0949827 0.19217 0.103332 GeneID:6549,Genbank:NM_003048.5,HGNC:HGNC:11072,MIM:600530 solute carrier family 9 member A2 GO:0005886,GO:0006811,GO:0008104,GO:0015385,GO:0015386,GO:0016021,GO:0051453,GO:0071805,GO:0098719 plasma membrane|ion transport|protein localization|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|regulation of intracellular pH|potassium ion transmembrane transport|sodium ion import across plasma membrane SLC9A3 114.540386575222 96.7919722124235 132.288800938021 1.36673318989404 0.45073163124948 0.105988951172686 1 0.882997 0.873535 1.14931 1.15868 GeneID:6550,Genbank:NM_001284351.2,HGNC:HGNC:11073,MIM:182307 solute carrier family 9 member A3 GO:0005886,GO:0005903,GO:0006811,GO:0009986,GO:0015385,GO:0015386,GO:0016021,GO:0016324,GO:0030165,GO:0031526,GO:0051453,GO:0070062,GO:0071805,GO:0098719 plasma membrane|brush border|ion transport|cell surface|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|apical plasma membrane|PDZ domain binding|brush border membrane|regulation of intracellular pH|extracellular exosome|potassium ion transmembrane transport|sodium ion import across plasma membrane hsa04964,hsa04974,hsa04976,hsa04978 Proximal tubule bicarbonate reclamation|Protein digestion and absorption|Bile secretion|Mineral absorption SLC9A3R1 1531.56316400712 1536.14548936026 1526.98083865398 0.99403399562753 -0.0086329025720616 0.929783645037573 1 29.8556 32.5825 30.2526 32.7999 GeneID:9368,Genbank:NM_004252.4,HGNC:HGNC:11075,MIM:604990 SLC9A3 regulator 1 hsa04530,hsa04928,hsa05165 Tight junction|Parathyroid hormone synthesis, secretion and action|Human papillomavirus infection SLC9A3R2 3244.80733873291 3171.38821211782 3318.226465348 1.04630093933916 0.0652978623388414 0.647977192250359 1 16.1887 16.9209 17.5855 17.9601 GeneID:9351,Genbank:NM_001130012.2,HGNC:HGNC:11076,MIM:606553 SLC9A3 regulator 2 GO:0005102,GO:0005634,GO:0005886,GO:0005925,GO:0006461,GO:0008013,GO:0008022,GO:0012505,GO:0016324,GO:0019902,GO:0032947,GO:0045296,GO:0070062 receptor binding|nucleus|plasma membrane|focal adhesion|protein complex assembly|beta-catenin binding|protein C-terminus binding|endomembrane system|apical plasma membrane|phosphatase binding|protein complex scaffold activity|cadherin binding|extracellular exosome hsa04960 Aldosterone-regulated sodium reabsorption SLC9A4 2.42816968217255 0.980142803914724 3.87619656043037 3.95472633676308 1.98357786505084 0.424270620283554 1 0 0.0189124 0.0288471 0.0269057 GeneID:389015,Genbank:XM_011511158.1,HGNC:HGNC:11077,MIM:600531 solute carrier family 9 member A4 GO:0001696,GO:0002064,GO:0005886,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0016323,GO:0016324,GO:0051453,GO:0071805,GO:0098719 gastric acid secretion|epithelial cell development|plasma membrane|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|basolateral plasma membrane|apical plasma membrane|regulation of intracellular pH|potassium ion transmembrane transport|sodium ion import across plasma membrane hsa04971 Gastric acid secretion SLC9A5 50.0216236388783 49.6500820760016 50.3931652017551 1.01496640276679 0.0214319723720605 0.991803276721589 1 0.372355 0.390808 0.311654 0.445096 GeneID:6553,Genbank:XM_017023594.1,HGNC:HGNC:11078,MIM:600477 solute carrier family 9 member A5 GO:0005886,GO:0006810,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0051453,GO:0071805,GO:0098719 plasma membrane|transport|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|regulation of intracellular pH|potassium ion transmembrane transport|sodium ion import across plasma membrane SLC9A6 954.779825286957 881.054656465652 1028.50499410826 1.16735662942195 0.22324537415497 0.254460167200374 1 8.04464 7.87307 10.83 7.96942 GeneID:10479,Genbank:XM_017029223.2,HGNC:HGNC:11079,MIM:300231 solute carrier family 9 member A6 GO:0005770,GO:0005789,GO:0005886,GO:0006810,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0030425,GO:0031547,GO:0031901,GO:0043231,GO:0043679,GO:0044308,GO:0048675,GO:0048812,GO:0050808,GO:0051386,GO:0051453,GO:0055038,GO:0060996,GO:0071805,GO:0097484,GO:0098719 late endosome|endoplasmic reticulum membrane|plasma membrane|transport|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|dendrite|brain-derived neurotrophic factor receptor signaling pathway|early endosome membrane|intracellular membrane-bounded organelle|axon terminus|axonal spine|axon extension|neuron projection morphogenesis|synapse organization|regulation of neurotrophin TRK receptor signaling pathway|regulation of intracellular pH|recycling endosome membrane|dendritic spine development|potassium ion transmembrane transport|dendrite extension|sodium ion import across plasma membrane hsa04260 Cardiac muscle contraction SLC9A7 514.12724378037 512.528081199699 515.726406361041 1.0062402925394 0.00897486524183632 0.970383007884292 1 2.03337 1.99544 2.49835 1.67924 GeneID:84679,Genbank:NM_032591.2,HGNC:HGNC:17123,MIM:300368 solute carrier family 9 member A7 GO:0000139,GO:0005802,GO:0005886,GO:0006811,GO:0006885,GO:0015385,GO:0015386,GO:0016021,GO:0042803,GO:0043231,GO:0051453,GO:0055038,GO:0098719 Golgi membrane|trans-Golgi network|plasma membrane|ion transport|regulation of pH|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|protein homodimerization activity|intracellular membrane-bounded organelle|regulation of intracellular pH|recycling endosome membrane|sodium ion import across plasma membrane SLC9A8 449.660057008735 420.954406620283 478.365707397188 1.1363836555076 0.184449986650905 0.315779677475453 1 1.99747 2.32078 2.74295 2.21083 GeneID:23315,Genbank:NM_001260491.1,HGNC:HGNC:20728,MIM:612730 solute carrier family 9 member A8 GO:0000139,GO:0005794,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0051453,GO:0071805 Golgi membrane|Golgi apparatus|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|regulation of intracellular pH|potassium ion transmembrane transport SLC9A9 33.9711852380896 32.0751551904374 35.8672152857419 1.11822421661844 0.161209493879695 0.784599608396416 1 0.0883668 0.122951 0.149052 0.0991287 GeneID:285195,Genbank:NM_173653.3,HGNC:HGNC:20653,MIM:608396 solute carrier family 9 member A9 GO:0005886,GO:0006811,GO:0015385,GO:0015386,GO:0016021,GO:0031902,GO:0051453,GO:0055037,GO:0071805,GO:0098719 plasma membrane|ion transport|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|late endosome membrane|regulation of intracellular pH|recycling endosome|potassium ion transmembrane transport|sodium ion import across plasma membrane SLC9B1 17.5325929816045 18.1130245622065 16.9521614010024 0.935910032186106 -0.095558242810852 0.966957050470433 1 0 0.018219 0 0.0334908 GeneID:150159,Genbank:NM_001100874.2,HGNC:HGNC:24244,MIM:611527 solute carrier family 9 member B1 GO:0005886,GO:0007338,GO:0015385,GO:0016021,GO:0030317,GO:0034220,GO:0051453,GO:0097228 plasma membrane|single fertilization|sodium:proton antiporter activity|integral component of membrane|flagellated sperm motility|ion transmembrane transport|regulation of intracellular pH|sperm principal piece SLC9B2 96.4648975392836 99.8862881033304 93.0435069752367 0.931494289576414 -0.102381169977069 0.744067530296968 1 0.54704 0.638058 0.521914 0.613124 GeneID:133308,Genbank:XM_006714085.3,HGNC:HGNC:25143,MIM:611789 solute carrier family 9 member B2 GO:0005451,GO:0005743,GO:0005886,GO:0006814,GO:0010008,GO:0010348,GO:0015385,GO:0016021,GO:0016323,GO:0016324,GO:0030054,GO:0030317,GO:0030672,GO:0031966,GO:0034220,GO:0042802,GO:0061178,GO:0072583,GO:0097228,GO:2001206 monovalent cation:proton antiporter activity|mitochondrial inner membrane|plasma membrane|sodium ion transport|endosome membrane|lithium:proton antiporter activity|sodium:proton antiporter activity|integral component of membrane|basolateral plasma membrane|apical plasma membrane|cell junction|flagellated sperm motility|synaptic vesicle membrane|mitochondrial membrane|ion transmembrane transport|identical protein binding|regulation of insulin secretion involved in cellular response to glucose stimulus|clathrin-dependent endocytosis|sperm principal piece|positive regulation of osteoclast development SLC9C2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:284525,Genbank:NM_178527.3,HGNC:HGNC:28664 solute carrier family 9 member C2 (putative) GO:0005886,GO:0015385,GO:0015386,GO:0016021,GO:0051453,GO:0071805,GO:0098719 plasma membrane|sodium:proton antiporter activity|potassium:proton antiporter activity|integral component of membrane|regulation of intracellular pH|potassium ion transmembrane transport|sodium ion import across plasma membrane SLCO1A2 0.974704718517834 0.980142803914724 0.969266633120943 0.98890348350226 -0.0160983733645535 1 1 0 0.00292826 0.00289095 0.00268817 GeneID:6579,Genbank:XM_024449139.1,HGNC:HGNC:10956,MIM:602883 solute carrier organic anion transporter family member 1A2 GO:0005886,GO:0005887,GO:0008514,GO:0015125,GO:0015347,GO:0015711,GO:0015721,GO:0043252 plasma membrane|integral component of plasma membrane|organic anion transmembrane transporter activity|bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|organic anion transport|bile acid and bile salt transport|sodium-independent organic anion transport hsa04976 Bile secretion SLCO1B1 1.97342257437814 2.00831188251439 1.93853326624189 0.965255089670065 -0.0510178385486115 1 1 0.0162259 0.0321531 0.0316145 0.0293334 GeneID:10599,Genbank:NM_006446.4,HGNC:HGNC:10959,MIM:604843 solute carrier organic anion transporter family member 1B1 hsa04976 Bile secretion SLCO1B3 90.5850559814985 97.8201412910231 83.3499706719739 0.852073709687259 -0.230949856923832 0.47582728387864 1 1.19596 1.06687 0.901934 1.13149 GeneID:28234,Genbank:NM_019844.3,HGNC:HGNC:10961,MIM:605495 solute carrier organic anion transporter family member 1B3 GO:0005886,GO:0005887,GO:0008514,GO:0015125,GO:0015347,GO:0015711,GO:0015721,GO:0016323,GO:0043252 plasma membrane|integral component of plasma membrane|organic anion transmembrane transporter activity|bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|organic anion transport|bile acid and bile salt transport|basolateral plasma membrane|sodium-independent organic anion transport hsa04976 Bile secretion SLCO1B7 1.70644029971538 1.96028560782945 1.45259499160132 0.741011914692228 -0.432431355150858 0.969832708614035 1 0 0.103996 0 0.0239598 GeneID:338821,Genbank:NM_001009562.4,HGNC:HGNC:32934 solute carrier organic anion transporter family member 1B7 (putative) GO:0005887,GO:0015125,GO:0015347,GO:0043252 integral component of plasma membrane|bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|sodium-independent organic anion transport hsa04976 Bile secretion SLCO2A1 14.6703403080952 21.1014792486356 8.23920136755471 0.390456103596976 -1.35676773008646 0.0748846101763343 0.94157495521624 0.159468 0.125351 0.0527072 0.0492461 GeneID:6578,Genbank:NM_005630.2,HGNC:HGNC:10955,MIM:601460 solute carrier organic anion transporter family member 2A1 SLCO3A1 1288.73013762751 1264.07266838222 1313.3876068728 1.03901274010907 0.0552133443090063 0.712441497994118 1 8.27577 8.45422 9.17901 8.26679 GeneID:28232,Genbank:NM_001145044.1,HGNC:HGNC:10952,MIM:612435 solute carrier organic anion transporter family member 3A1 GO:0005886,GO:0005887,GO:0015347,GO:0015732,GO:0043252 plasma membrane|integral component of plasma membrane|sodium-independent organic anion transmembrane transporter activity|prostaglandin transport|sodium-independent organic anion transport SLCO4A1 568.353892966988 648.642452429152 488.065333504824 0.752441243518721 -0.410349165498392 0.111958674326207 1 4.25462 5.42784 4.19128 3.16351 GeneID:28231,Genbank:XM_005260203.3,HGNC:HGNC:10953,MIM:612436 solute carrier organic anion transporter family member 4A1 GO:0005886,GO:0005887,GO:0015347,GO:0015349,GO:0043252,GO:0070327 plasma membrane|integral component of plasma membrane|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity|sodium-independent organic anion transport|thyroid hormone transport SLCO5A1 193.962275570133 189.682990519404 198.241560620861 1.04512038785355 0.0636691365220578 0.796242441205981 1 0.554627 0.650662 0.77658 0.545663 GeneID:81796,Genbank:XM_005251313.2,HGNC:HGNC:19046,MIM:613543 solute carrier organic anion transporter family member 5A1 GO:0005887,GO:0015347,GO:0043252 integral component of plasma membrane|sodium-independent organic anion transmembrane transporter activity|sodium-independent organic anion transport SLF1 138.580239058012 147.268309613177 129.892168502847 0.882010317386198 -0.181132562965287 0.508193757096572 1 0.322537 0.30408 0.324665 0.251334 GeneID:84250,Genbank:XM_017009979.2,HGNC:HGNC:25408 SMC5-SMC6 complex localization factor 1 GO:0000786,GO:0005634,GO:0005737,GO:0005813,GO:0006281,GO:0006974,GO:0031334,GO:0031625,GO:0032403,GO:0034184,GO:0035861,GO:0042405,GO:1990166,GO:2000781 nucleosome|nucleus|cytoplasm|centrosome|DNA repair|cellular response to DNA damage stimulus|positive regulation of protein complex assembly|ubiquitin protein ligase binding|protein complex binding|positive regulation of maintenance of mitotic sister chromatid cohesion|site of double-strand break|nuclear inclusion body|protein localization to site of double-strand break|positive regulation of double-strand break repair SLF2 670.599853216905 660.689272721674 680.510433712135 1.03000073076532 0.0426453609727025 0.84708521695513 1 2.34058 2.12186 2.65463 1.91233 GeneID:55719,Genbank:XM_011539944.3,HGNC:HGNC:17814,MIM:610348 SMC5-SMC6 complex localization factor 2 GO:0000785,GO:0005615,GO:0005634,GO:0006281,GO:0006974,GO:0031334,GO:0031625,GO:0032403,GO:0034184,GO:0035861,GO:0043231,GO:1990166,GO:2000781 chromatin|extracellular space|nucleus|DNA repair|cellular response to DNA damage stimulus|positive regulation of protein complex assembly|ubiquitin protein ligase binding|protein complex binding|positive regulation of maintenance of mitotic sister chromatid cohesion|site of double-strand break|intracellular membrane-bounded organelle|protein localization to site of double-strand break|positive regulation of double-strand break repair SLFN11 1659.75953746668 1578.63355450308 1740.88552043029 1.1027800058249 0.141145015624729 0.314300098100482 1 11.311 10.6454 13.1372 11.1176 GeneID:91607,Genbank:NM_001104590.1,HGNC:HGNC:26633,MIM:614953 schlafen family member 11 GO:0000049,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0016235,GO:0051607,GO:2000134 tRNA binding|ATP binding|nucleus|nucleoplasm|cytosol|aggresome|defense response to virus|negative regulation of G1/S transition of mitotic cell cycle SLFN12 429.009031735352 407.741079076795 450.276984393908 1.10432087297513 0.143159424461971 0.492188195913544 1 2.3527 2.15232 2.94757 2.1397 GeneID:55106,Genbank:XM_024450822.1,HGNC:HGNC:25500,MIM:614955 schlafen family member 12 GO:0005524 ATP binding SLFN12L 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00760817 0 GeneID:100506736,Genbank:XM_017024005.1,HGNC:HGNC:33920,MIM:614956 schlafen family member 12 like GO:0005524,GO:0016021 ATP binding|integral component of membrane SLFN13 37.5056436206042 36.7161205263704 38.2951667148379 1.0430068908651 0.0607486893860285 0.909399833152908 1 0.177452 0.127007 0.195089 0.128986 GeneID:146857,Genbank:NM_144682.5,HGNC:HGNC:26481,MIM:614957 schlafen family member 13 GO:0005524,GO:0005622 ATP binding|intracellular SLFN5 412.687569255071 366.402593523853 458.972544986288 1.25264545911684 0.324978141114546 0.0699426782280375 0.92021045003939 1.30334 1.1298 1.6767 1.37883 GeneID:162394,Genbank:NM_001330183.1,HGNC:HGNC:28286,MIM:614952 schlafen family member 5 GO:0005524,GO:0005634,GO:0030154 ATP binding|nucleus|cell differentiation SLFNL1 2.72166664386287 1.56626675524197 3.87706653248377 2.4753551842354 1.30763554974577 0.556446753005391 1 0 0 0 0.0143794 GeneID:200172,Genbank:XM_011540953.3,HGNC:HGNC:26313 schlafen like 1 GO:0005524 ATP binding SLIRP 779.003188933328 852.43942705424 705.566950812415 0.827703328142189 -0.272814336478792 0.0863880164469005 0.964561165794104 85.9973 89.545 70.8127 81.3128 GeneID:81892,Genbank:NM_001267864.1,HGNC:HGNC:20495,MIM:610211 SRA stem-loop interacting RNA binding protein GO:0000961,GO:0001669,GO:0003723,GO:0005634,GO:0005739,GO:0006351,GO:0006355,GO:0007286,GO:0007338,GO:0030317,GO:0030529,GO:0036126,GO:0048471,GO:0070584 negative regulation of mitochondrial RNA catabolic process|acrosomal vesicle|RNA binding|nucleus|mitochondrion|transcription, DNA-templated|regulation of transcription, DNA-templated|spermatid development|single fertilization|flagellated sperm motility|intracellular ribonucleoprotein complex|sperm flagellum|perinuclear region of cytoplasm|mitochondrion morphogenesis SLIT1 6.26385752316808 7.19718355019767 5.33053149613849 0.740641316003687 -0.433153063699378 0.772771707616064 1 0.0347921 0.0252985 0.0162001 0.0201415 GeneID:6585,Genbank:NM_003061.2,HGNC:HGNC:11085,MIM:603742 slit guidance ligand 1 GO:0005509,GO:0005615,GO:0005622,GO:0007097,GO:0007411,GO:0008045,GO:0022028,GO:0031290,GO:0033563,GO:0048495,GO:0048846,GO:0048853,GO:0050919,GO:0051964 calcium ion binding|extracellular space|intracellular|nuclear migration|axon guidance|motor neuron axon guidance|tangential migration from the subventricular zone to the olfactory bulb|retinal ganglion cell axon guidance|dorsal/ventral axon guidance|Roundabout binding|axon extension involved in axon guidance|forebrain morphogenesis|negative chemotaxis|negative regulation of synapse assembly hsa04360 Axon guidance SLIT2 1722.77422269249 1764.10883315957 1681.43961222541 0.953138253502144 -0.0692426014494376 0.767665707722306 1 6.28651 6.35755 7.50308 4.94674 GeneID:9353,Genbank:XM_005248211.3,HGNC:HGNC:11086,MIM:603746 slit guidance ligand 2 hsa04360 Axon guidance SLIT3 444.494850878115 408.712430226457 480.277271529774 1.1750982745097 0.23278141570008 0.203439597853043 1 1.20364 1.35669 1.61103 1.38392 GeneID:6586,Genbank:NM_003062.3,HGNC:HGNC:11087,MIM:603745 slit guidance ligand 3 hsa04360 Axon guidance SLITRK1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00806898 0 0 GeneID:114798,Genbank:NM_001281503.1,HGNC:HGNC:20297,MIM:609678 SLIT and NTRK like family member 1 SLITRK2 343.450144675755 352.988369227372 333.911920124138 0.945957287077223 -0.0801530520341696 0.708580670368549 1 1.69011 1.43016 1.51414 1.45128 GeneID:84631,Genbank:NM_032539.4,HGNC:HGNC:13449,MIM:300561 SLIT and NTRK like family member 2 GO:0005886,GO:0007409,GO:0016021,GO:0051965 plasma membrane|axonogenesis|integral component of membrane|positive regulation of synapse assembly SLITRK3 67.0763962665733 56.1072541957092 78.0455383374373 1.39100619797227 0.476128848179174 0.331751405806374 1 0.453334 0.387131 0.795921 0.415931 GeneID:22865,Genbank:NM_001318811.1,HGNC:HGNC:23501,MIM:609679 SLIT and NTRK like family member 3 GO:0005886,GO:0007409,GO:0016021,GO:0051965 plasma membrane|axonogenesis|integral component of membrane|positive regulation of synapse assembly SLITRK5 203.452260813767 205.26922283267 201.635298794865 0.982296790587223 -0.0257691094338714 0.911895188266662 1 1.4103 1.69037 1.84131 1.26181 GeneID:26050,Genbank:XM_005254038.5,HGNC:HGNC:20295,MIM:609680 SLIT and NTRK like family member 5 GO:0005886,GO:0007268,GO:0007409,GO:0007625,GO:0009410,GO:0016021,GO:0021756,GO:0030534,GO:0043235,GO:0043588,GO:0048813,GO:0051965,GO:0072358 plasma membrane|chemical synaptic transmission|axonogenesis|grooming behavior|response to xenobiotic stimulus|integral component of membrane|striatum development|adult behavior|receptor complex|skin development|dendrite morphogenesis|positive regulation of synapse assembly|cardiovascular system development SLITRK6 16.2055113567713 17.8728931887818 14.5381295247607 0.813417803777053 -0.297931526585761 0.698837146573079 1 0.122683 0.184198 0.127741 0.127411 GeneID:84189,Genbank:NM_032229.2,HGNC:HGNC:23503,MIM:609681 SLIT and NTRK like family member 6 GO:0001964,GO:0002088,GO:0002093,GO:0005886,GO:0005887,GO:0007409,GO:0007416,GO:0007601,GO:0007605,GO:0008344,GO:0009986,GO:0021562,GO:0031223,GO:0035264,GO:0051965,GO:0060007,GO:0060384,GO:0090102 startle response|lens development in camera-type eye|auditory receptor cell morphogenesis|plasma membrane|integral component of plasma membrane|axonogenesis|synapse assembly|visual perception|sensory perception of sound|adult locomotory behavior|cell surface|vestibulocochlear nerve development|auditory behavior|multicellular organism growth|positive regulation of synapse assembly|linear vestibuloocular reflex|innervation|cochlea development SLK 475.928704509506 451.605339877824 500.252069141188 1.10771956167862 0.147592684468967 0.725952530478651 1 2.19416 1.68488 2.86009 1.57285 GeneID:9748,Genbank:XM_011540401.3,HGNC:HGNC:11088,MIM:616563 STE20 like kinase GO:0004674,GO:0005524,GO:0005737,GO:0006915,GO:0007346,GO:0023014,GO:0030334,GO:0031098,GO:0031122,GO:0031252,GO:0032147,GO:0042802,GO:0042803,GO:0042981,GO:0045296,GO:0046777,GO:0048471,GO:0051893,GO:0070062 protein serine/threonine kinase activity|ATP binding|cytoplasm|apoptotic process|regulation of mitotic cell cycle|signal transduction by protein phosphorylation|regulation of cell migration|stress-activated protein kinase signaling cascade|cytoplasmic microtubule organization|cell leading edge|activation of protein kinase activity|identical protein binding|protein homodimerization activity|regulation of apoptotic process|cadherin binding|protein autophosphorylation|perinuclear region of cytoplasm|regulation of focal adhesion assembly|extracellular exosome hsa04114 Oocyte meiosis SLMAP 723.970190718274 710.204067627874 737.736313808673 1.03876666923742 0.0548716283151892 0.854729523389006 1 3.34555 2.70484 3.97956 2.40305 GeneID:7871,Genbank:XM_005265458.4,HGNC:HGNC:16643,MIM:602701 sarcolemma associated protein GO:0005790,GO:0005815,GO:0005887,GO:0006936,GO:0042383,GO:0072659,GO:1900825,GO:1902305,GO:1905150 smooth endoplasmic reticulum|microtubule organizing center|integral component of plasma membrane|muscle contraction|sarcolemma|protein localization to plasma membrane|regulation of membrane depolarization during cardiac muscle cell action potential|regulation of sodium ion transmembrane transport|regulation of voltage-gated sodium channel activity SLN 1.48422114447417 1.02816907859967 1.94027321034868 1.88711492179017 0.916182283059343 0.868213715678306 1 0.0780869 0 0.294354 0 GeneID:6588,Genbank:NM_003063.2,HGNC:HGNC:11089,MIM:602203 sarcolipin GO:0004857,GO:0006816,GO:0016021,GO:0016529,GO:0033017,GO:0043086,GO:0043242,GO:0051117,GO:0051924,GO:0070296,GO:0090281,GO:1901020,GO:1901077,GO:1901877,GO:1901881,GO:1901894 enzyme inhibitor activity|calcium ion transport|integral component of membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane|negative regulation of catalytic activity|negative regulation of protein complex disassembly|ATPase binding|regulation of calcium ion transport|sarcoplasmic reticulum calcium ion transport|negative regulation of calcium ion import|negative regulation of calcium ion transmembrane transporter activity|regulation of relaxation of muscle|negative regulation of calcium ion binding|positive regulation of protein depolymerization|regulation of calcium-transporting ATPase activity SLPI 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0 0 0.158995 0.0736547 GeneID:6590,Genbank:NM_003064.3,HGNC:HGNC:11092,MIM:107285 secretory leukocyte peptidase inhibitor GO:0003677,GO:0003729,GO:0004866,GO:0004867,GO:0005576,GO:0005615,GO:0006955,GO:0019731,GO:0019899,GO:0032091,GO:0032496,GO:0035580,GO:0035821,GO:0043312,GO:0045071,GO:0045087,GO:0070062 DNA binding|mRNA binding|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|immune response|antibacterial humoral response|enzyme binding|negative regulation of protein binding|response to lipopolysaccharide|specific granule lumen|modification of morphology or physiology of other organism|neutrophil degranulation|negative regulation of viral genome replication|innate immune response|extracellular exosome SLTM 744.801465954308 803.288208034449 686.314723874166 0.854381673986597 -0.2270473925391 0.221835236918518 1 2.95039 2.72733 2.74232 2.10898 GeneID:79811,Genbank:NM_001013843.2,HGNC:HGNC:20709 SAFB like transcription modulator GO:0003690,GO:0003723,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0006915,GO:0016604,GO:0043565,GO:0050684 double-stranded DNA binding|RNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|apoptotic process|nuclear body|sequence-specific DNA binding|regulation of mRNA processing SLU7 658.046736068036 726.280371343097 589.813100792975 0.812101116958791 -0.300268722338239 0.131836497260841 1 5.32927 4.50339 4.37025 3.78063 GeneID:10569,Genbank:NM_006425.4,HGNC:HGNC:16939,MIM:605974 SLU7 homolog, splicing factor GO:0000375,GO:0000380,GO:0000386,GO:0000389,GO:0000398,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0005829,GO:0006369,GO:0006405,GO:0006406,GO:0006886,GO:0008270,GO:0016020,GO:0016607,GO:0030532,GO:0030628,GO:0031124,GO:0034605,GO:0043231,GO:0071013 RNA splicing, via transesterification reactions|alternative mRNA splicing, via spliceosome|second spliceosomal transesterification activity|mRNA 3'-splice site recognition|mRNA splicing, via spliceosome|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|cytosol|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|intracellular protein transport|zinc ion binding|membrane|nuclear speck|small nuclear ribonucleoprotein complex|pre-mRNA 3'-splice site binding|mRNA 3'-end processing|cellular response to heat|intracellular membrane-bounded organelle|catalytic step 2 spliceosome hsa03040 Spliceosome SLX1A 13.7984053700346 11.6078261678139 15.9889845722553 1.37743142782319 0.461980499412143 0.597179679846649 1 0 0.290041 0.0627675 0.470271 GeneID:548593,Genbank:NM_001014999.2,HGNC:HGNC:20922,MIM:615822 SLX1 homolog A, structure-specific endonuclease subunit GO:0000724,GO:0004520,GO:0005654,GO:0006281,GO:0008821,GO:0010792,GO:0010833,GO:0017108,GO:0033557,GO:0036297,GO:0046872,GO:0061820,GO:0090656,GO:1904357,GO:1904431 double-strand break repair via homologous recombination|endodeoxyribonuclease activity|nucleoplasm|DNA repair|crossover junction endodeoxyribonuclease activity|DNA double-strand break processing involved in repair via single-strand annealing|telomere maintenance via telomere lengthening|5'-flap endonuclease activity|Slx1-Slx4 complex|interstrand cross-link repair|metal ion binding|telomeric D-loop disassembly|t-circle formation|negative regulation of telomere maintenance via telomere lengthening|positive regulation of t-circle formation hsa03460 Fanconi anemia pathway SLX1B 37.4943621442469 5.6309167949557 69.3578074935381 12.3173206103259 3.6226165552545 0.242346467624751 1 0.0688994 0.174025 7.97148 0.117568 GeneID:79008,Genbank:NM_024044.3,HGNC:HGNC:28748,MIM:615823 SLX1 homolog B, structure-specific endonuclease subunit GO:0000724,GO:0004520,GO:0005654,GO:0006281,GO:0008821,GO:0010792,GO:0010833,GO:0017108,GO:0033557,GO:0036297,GO:0046872,GO:0061820,GO:0090656,GO:1904357,GO:1904431 double-strand break repair via homologous recombination|endodeoxyribonuclease activity|nucleoplasm|DNA repair|crossover junction endodeoxyribonuclease activity|DNA double-strand break processing involved in repair via single-strand annealing|telomere maintenance via telomere lengthening|5'-flap endonuclease activity|Slx1-Slx4 complex|interstrand cross-link repair|metal ion binding|telomeric D-loop disassembly|t-circle formation|negative regulation of telomere maintenance via telomere lengthening|positive regulation of t-circle formation hsa03460 Fanconi anemia pathway SLX4 478.382359822729 467.279850087061 489.484869558397 1.04751974532435 0.0669774384000772 0.729862510786065 1 1.51826 1.64779 1.77421 1.61917 GeneID:84464,Genbank:XM_011522715.3,HGNC:HGNC:23845,MIM:613278 SLX4 structure-specific endonuclease subunit hsa03460 Fanconi anemia pathway SLX4IP 51.983964695581 53.5608446365525 50.4070847546094 0.941118182445711 -0.0875521917822069 0.860674261246248 1 0.178948 0.148072 0.182465 0.129269 GeneID:128710,Genbank:XM_024451828.1,HGNC:HGNC:16225,MIM:615958 SLX4 interacting protein SMAD1 357.397906610067 376.49217921111 338.303634009025 0.898567494065602 -0.154301221985042 0.437839787539934 1 4.32161 3.69921 3.88716 3.10277 GeneID:4086,Genbank:NM_001354812.1,HGNC:HGNC:6767,MIM:601595 SMAD family member 1 GO:0000165,GO:0000978,GO:0001077,GO:0001657,GO:0001710,GO:0002051,GO:0003700,GO:0005057,GO:0005622,GO:0005634,GO:0005637,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006954,GO:0007165,GO:0007179,GO:0007183,GO:0007276,GO:0008285,GO:0009880,GO:0010628,GO:0016021,GO:0016579,GO:0017151,GO:0019901,GO:0030509,GO:0030618,GO:0030901,GO:0030902,GO:0031053,GO:0042592,GO:0042802,GO:0042803,GO:0043234,GO:0045669,GO:0045944,GO:0046872,GO:0046982,GO:0051216,GO:0060038,GO:0060348,GO:0060395,GO:0061036,GO:0070410,GO:0070411,GO:0070878,GO:0071141,GO:1901522,GO:1902895 MAPK cascade|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|ureteric bud development|mesodermal cell fate commitment|osteoblast fate commitment|DNA binding transcription factor activity|signal transducer activity, downstream of receptor|intracellular|nucleus|nuclear inner membrane|nucleoplasm|transcription factor complex|cytoplasm|cytosol|inflammatory response|signal transduction|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|gamete generation|negative regulation of cell proliferation|embryonic pattern specification|positive regulation of gene expression|integral component of membrane|protein deubiquitination|DEAD/H-box RNA helicase binding|protein kinase binding|BMP signaling pathway|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|midbrain development|hindbrain development|primary miRNA processing|homeostatic process|identical protein binding|protein homodimerization activity|protein complex|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|protein heterodimerization activity|cartilage development|cardiac muscle cell proliferation|bone development|SMAD protein signal transduction|positive regulation of cartilage development|co-SMAD binding|I-SMAD binding|primary miRNA binding|SMAD protein complex|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|positive regulation of pri-miRNA transcription from RNA polymerase II promoter hsa04350,hsa04390,hsa04550,hsa05202 TGF-beta signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Transcriptional misregulation in cancer SMAD2 577.387396402126 604.217425638701 550.55736716555 0.911190812783281 -0.134174893955055 0.441461743265543 1 1.19896 1.05803 1.13804 0.971398 GeneID:4087,Genbank:NM_001135937.2,HGNC:HGNC:6768,MIM:601366 SMAD family member 2 GO:0000790,GO:0000978,GO:0001077,GO:0001657,GO:0001701,GO:0001706,GO:0001707,GO:0003682,GO:0003690,GO:0003700,GO:0005160,GO:0005634,GO:0005667,GO:0005737,GO:0006468,GO:0007179,GO:0007182,GO:0007183,GO:0007352,GO:0007369,GO:0007389,GO:0007492,GO:0007507,GO:0008134,GO:0008285,GO:0009749,GO:0009791,GO:0009880,GO:0009952,GO:0010628,GO:0010629,GO:0010718,GO:0017015,GO:0019902,GO:0023019,GO:0030073,GO:0030324,GO:0030513,GO:0030618,GO:0031016,GO:0031625,GO:0032444,GO:0032924,GO:0033613,GO:0034713,GO:0035265,GO:0035556,GO:0038092,GO:0042060,GO:0042803,GO:0043234,GO:0045165,GO:0045892,GO:0045893,GO:0045944,GO:0046332,GO:0046872,GO:0046982,GO:0048340,GO:0048589,GO:0048617,GO:0048701,GO:0051098,GO:0060021,GO:0060039,GO:0060395,GO:0070410,GO:0070411,GO:0070412,GO:0070723,GO:0070878,GO:0071141,GO:0071144,GO:0097718,GO:1900224 nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|ureteric bud development|in utero embryonic development|endoderm formation|mesoderm formation|chromatin binding|double-stranded DNA binding|DNA binding transcription factor activity|transforming growth factor beta receptor binding|nucleus|transcription factor complex|cytoplasm|protein phosphorylation|transforming growth factor beta receptor signaling pathway|common-partner SMAD protein phosphorylation|SMAD protein complex assembly|zygotic specification of dorsal/ventral axis|gastrulation|pattern specification process|endoderm development|heart development|transcription factor binding|negative regulation of cell proliferation|response to glucose|post-embryonic development|embryonic pattern specification|anterior/posterior pattern specification|positive regulation of gene expression|negative regulation of gene expression|positive regulation of epithelial to mesenchymal transition|regulation of transforming growth factor beta receptor signaling pathway|phosphatase binding|signal transduction involved in regulation of gene expression|insulin secretion|lung development|positive regulation of BMP signaling pathway|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|pancreas development|ubiquitin protein ligase binding|activin responsive factor complex|activin receptor signaling pathway|activating transcription factor binding|type I transforming growth factor beta receptor binding|organ growth|intracellular signal transduction|nodal signaling pathway|wound healing|protein homodimerization activity|protein complex|cell fate commitment|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|SMAD binding|metal ion binding|protein heterodimerization activity|paraxial mesoderm morphogenesis|developmental growth|embryonic foregut morphogenesis|embryonic cranial skeleton morphogenesis|regulation of binding|palate development|pericardium development|SMAD protein signal transduction|co-SMAD binding|I-SMAD binding|R-SMAD binding|response to cholesterol|primary miRNA binding|SMAD protein complex|heteromeric SMAD protein complex|disordered domain specific binding|positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry hsa04068,hsa04110,hsa04144,hsa04218,hsa04350,hsa04371,hsa04390,hsa04520,hsa04550,hsa04659,hsa04926,hsa04933,hsa05142,hsa05166,hsa05200,hsa05205,hsa05210,hsa05212,hsa05225,hsa05226,hsa05321 FoxO signaling pathway|Cell cycle|Endocytosis|Cellular senescence|TGF-beta signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Th17 cell differentiation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Chagas disease (American trypanosomiasis)|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Pancreatic cancer|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease (IBD) SMAD3 3812.34288498118 4038.827747534 3585.85802242837 0.887846238210531 -0.171618250045074 0.19433336522446 1 19.4113 20.9579 19.0784 17.2925 GeneID:4088,Genbank:NM_005902.3,HGNC:HGNC:6769,MIM:603109 SMAD family member 3 GO:0000122,GO:0000790,GO:0000978,GO:0000983,GO:0000987,GO:0001102,GO:0001657,GO:0001666,GO:0001701,GO:0001707,GO:0001756,GO:0001889,GO:0001947,GO:0002076,GO:0002520,GO:0003700,GO:0005160,GO:0005518,GO:0005634,GO:0005637,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0006357,GO:0006919,GO:0006955,GO:0007050,GO:0007179,GO:0007183,GO:0007492,GO:0008013,GO:0008134,GO:0008270,GO:0009880,GO:0010628,GO:0010694,GO:0010718,GO:0016202,GO:0016579,GO:0017015,GO:0017151,GO:0019049,GO:0019901,GO:0019902,GO:0023019,GO:0030308,GO:0030335,GO:0030501,GO:0030512,GO:0030618,GO:0030878,GO:0031053,GO:0031490,GO:0031625,GO:0031962,GO:0032332,GO:0032731,GO:0032909,GO:0032916,GO:0032924,GO:0033689,GO:0035259,GO:0035326,GO:0035413,GO:0038092,GO:0042060,GO:0042110,GO:0042177,GO:0042802,GO:0042803,GO:0042993,GO:0043066,GO:0043130,GO:0043235,GO:0043425,GO:0043565,GO:0044212,GO:0045216,GO:0045429,GO:0045599,GO:0045668,GO:0045893,GO:0045930,GO:0045944,GO:0046982,GO:0048340,GO:0048589,GO:0048617,GO:0048701,GO:0050678,GO:0050728,GO:0050776,GO:0050821,GO:0050927,GO:0051098,GO:0051481,GO:0051496,GO:0051894,GO:0060039,GO:0060070,GO:0060290,GO:0060391,GO:0060395,GO:0061045,GO:0061767,GO:0070306,GO:0070410,GO:0070412,GO:0070878,GO:0071141,GO:0071144,GO:0071345,GO:0071560,GO:0097191,GO:0097296,GO:1901203,GO:1902895,GO:1903243 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding|proximal promoter sequence-specific DNA binding|RNA polymerase II activating transcription factor binding|ureteric bud development|response to hypoxia|in utero embryonic development|mesoderm formation|somitogenesis|liver development|heart looping|osteoblast development|immune system development|DNA binding transcription factor activity|transforming growth factor beta receptor binding|collagen binding|nucleus|nuclear inner membrane|nucleoplasm|transcription factor complex|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|activation of cysteine-type endopeptidase activity involved in apoptotic process|immune response|cell cycle arrest|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|endoderm development|beta-catenin binding|transcription factor binding|zinc ion binding|embryonic pattern specification|positive regulation of gene expression|positive regulation of alkaline phosphatase activity|positive regulation of epithelial to mesenchymal transition|regulation of striated muscle tissue development|protein deubiquitination|regulation of transforming growth factor beta receptor signaling pathway|DEAD/H-box RNA helicase binding|evasion or tolerance of host defenses by virus|protein kinase binding|phosphatase binding|signal transduction involved in regulation of gene expression|negative regulation of cell growth|positive regulation of cell migration|positive regulation of bone mineralization|negative regulation of transforming growth factor beta receptor signaling pathway|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|thyroid gland development|primary miRNA processing|chromatin DNA binding|ubiquitin protein ligase binding|mineralocorticoid receptor binding|positive regulation of chondrocyte differentiation|positive regulation of interleukin-1 beta production|regulation of transforming growth factor beta2 production|positive regulation of transforming growth factor beta3 production|activin receptor signaling pathway|negative regulation of osteoblast proliferation|glucocorticoid receptor binding|enhancer binding|positive regulation of catenin import into nucleus|nodal signaling pathway|wound healing|T cell activation|negative regulation of protein catabolic process|identical protein binding|protein homodimerization activity|positive regulation of transcription factor import into nucleus|negative regulation of apoptotic process|ubiquitin binding|receptor complex|bHLH transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|cell-cell junction organization|positive regulation of nitric oxide biosynthetic process|negative regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|paraxial mesoderm morphogenesis|developmental growth|embryonic foregut morphogenesis|embryonic cranial skeleton morphogenesis|regulation of epithelial cell proliferation|negative regulation of inflammatory response|regulation of immune response|protein stabilization|positive regulation of positive chemotaxis|regulation of binding|negative regulation of cytosolic calcium ion concentration|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|pericardium development|canonical Wnt signaling pathway|transdifferentiation|positive regulation of SMAD protein import into nucleus|SMAD protein signal transduction|negative regulation of wound healing|negative regulation of lung blood pressure|lens fiber cell differentiation|co-SMAD binding|R-SMAD binding|primary miRNA binding|SMAD protein complex|heteromeric SMAD protein complex|cellular response to cytokine stimulus|cellular response to transforming growth factor beta stimulus|extrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|positive regulation of extracellular matrix assembly|positive regulation of pri-miRNA transcription from RNA polymerase II promoter|negative regulation of cardiac muscle hypertrophy in response to stress hsa04068,hsa04110,hsa04144,hsa04218,hsa04310,hsa04350,hsa04371,hsa04390,hsa04520,hsa04550,hsa04659,hsa04926,hsa04933,hsa05142,hsa05161,hsa05166,hsa05200,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321 FoxO signaling pathway|Cell cycle|Endocytosis|Cellular senescence|Wnt signaling pathway|TGF-beta signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Th17 cell differentiation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Chagas disease (American trypanosomiasis)|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease (IBD) SMAD4 382.934424974909 408.192932859176 357.675917090642 0.876242306757523 -0.19059822229933 0.311923561915608 1 2.19697 2.18732 2.11667 1.77884 GeneID:4089,Genbank:NM_005359.5,HGNC:HGNC:6770,MIM:600993 SMAD family member 4 hsa04068,hsa04110,hsa04310,hsa04350,hsa04371,hsa04390,hsa04520,hsa04550,hsa04659,hsa04933,hsa05161,hsa05166,hsa05200,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226 FoxO signaling pathway|Cell cycle|Wnt signaling pathway|TGF-beta signaling pathway|Apelin signaling pathway|Hippo signaling pathway|Adherens junction|Signaling pathways regulating pluripotency of stem cells|Th17 cell differentiation|AGE-RAGE signaling pathway in diabetic complications|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer SMAD5 507.559124246191 553.711662272624 461.406586219758 0.833297576442559 -0.263096310708717 0.215062804029736 1 3.40173 2.84183 3.00956 2.27029 GeneID:4090,Genbank:NM_001001419.2,HGNC:HGNC:6771,MIM:603110 SMAD family member 5 GO:0000122,GO:0000978,GO:0001657,GO:0001880,GO:0002051,GO:0003700,GO:0005057,GO:0005622,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006351,GO:0006468,GO:0007165,GO:0007179,GO:0007281,GO:0009880,GO:0016021,GO:0017151,GO:0030218,GO:0030509,GO:0030618,GO:0031625,GO:0043234,GO:0045669,GO:0045893,GO:0046872,GO:0051216,GO:0060048,GO:0060348,GO:0060395,GO:0071141,GO:0071407,GO:1901522 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|ureteric bud development|Mullerian duct regression|osteoblast fate commitment|DNA binding transcription factor activity|signal transducer activity, downstream of receptor|intracellular|nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytosol|transcription, DNA-templated|protein phosphorylation|signal transduction|transforming growth factor beta receptor signaling pathway|germ cell development|embryonic pattern specification|integral component of membrane|DEAD/H-box RNA helicase binding|erythrocyte differentiation|BMP signaling pathway|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding|protein complex|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-templated|metal ion binding|cartilage development|cardiac muscle contraction|bone development|SMAD protein signal transduction|SMAD protein complex|cellular response to organic cyclic compound|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus hsa04350,hsa04550 TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells SMAD6 613.548573043201 627.126320016858 599.970826069543 0.956698526149269 -0.0638637191314606 0.697668570432677 1 3.82508 4.02425 3.74544 3.74544 GeneID:4091,Genbank:NM_005585.4,HGNC:HGNC:6772,MIM:602931 SMAD family member 6 GO:0000978,GO:0001657,GO:0003148,GO:0003183,GO:0003184,GO:0003281,GO:0003682,GO:0003700,GO:0005634,GO:0005667,GO:0005737,GO:0005794,GO:0005829,GO:0006351,GO:0006955,GO:0007179,GO:0007352,GO:0008285,GO:0010991,GO:0016604,GO:0030279,GO:0030509,GO:0030512,GO:0030514,GO:0030617,GO:0031589,GO:0031625,GO:0034616,GO:0034713,GO:0035904,GO:0042802,GO:0043066,GO:0043234,GO:0043627,GO:0044212,GO:0045444,GO:0046872,GO:0060394,GO:0060976,GO:0070410,GO:0070411,GO:0070412,GO:0070698,GO:1902895 RNA polymerase II proximal promoter sequence-specific DNA binding|ureteric bud development|outflow tract septum morphogenesis|mitral valve morphogenesis|pulmonary valve morphogenesis|ventricular septum development|chromatin binding|DNA binding transcription factor activity|nucleus|transcription factor complex|cytoplasm|Golgi apparatus|cytosol|transcription, DNA-templated|immune response|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis|negative regulation of cell proliferation|negative regulation of SMAD protein complex assembly|nuclear body|negative regulation of ossification|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|cell-substrate adhesion|ubiquitin protein ligase binding|response to laminar fluid shear stress|type I transforming growth factor beta receptor binding|aorta development|identical protein binding|negative regulation of apoptotic process|protein complex|response to estrogen|transcription regulatory region DNA binding|fat cell differentiation|metal ion binding|negative regulation of pathway-restricted SMAD protein phosphorylation|coronary vasculature development|co-SMAD binding|I-SMAD binding|R-SMAD binding|type I activin receptor binding|positive regulation of pri-miRNA transcription from RNA polymerase II promoter hsa04350 TGF-beta signaling pathway SMAD7 125.125091765514 125.6963762728 124.553807258228 0.990910087876423 -0.0131739372330428 0.96049927539193 1 1.60539 1.99202 1.92706 1.7822 GeneID:4092,Genbank:NM_001190821.1,HGNC:HGNC:6773,MIM:602932 SMAD family member 7 GO:0000122,GO:0001650,GO:0001657,GO:0002725,GO:0003700,GO:0005518,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005813,GO:0005829,GO:0005886,GO:0006351,GO:0007179,GO:0008013,GO:0010717,GO:0010719,GO:0010801,GO:0010944,GO:0016579,GO:0017015,GO:0022409,GO:0030336,GO:0030509,GO:0030512,GO:0030514,GO:0030617,GO:0031397,GO:0031398,GO:0031625,GO:0032436,GO:0032925,GO:0033137,GO:0034333,GO:0034616,GO:0034629,GO:0034713,GO:0043234,GO:0043433,GO:0044212,GO:0045944,GO:0046872,GO:0048185,GO:0048844,GO:0050821,GO:0051444,GO:0055010,GO:0055117,GO:0060373,GO:0060389,GO:0060394,GO:0060412,GO:0070411,GO:0071560,GO:1990830,GO:2000317,GO:2000320 negative regulation of transcription from RNA polymerase II promoter|fibrillar center|ureteric bud development|negative regulation of T cell cytokine production|DNA binding transcription factor activity|collagen binding|nucleus|nucleoplasm|transcription factor complex|cytoplasm|centrosome|cytosol|plasma membrane|transcription, DNA-templated|transforming growth factor beta receptor signaling pathway|beta-catenin binding|regulation of epithelial to mesenchymal transition|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-threonine phosphorylation|negative regulation of transcription by competitive promoter binding|protein deubiquitination|regulation of transforming growth factor beta receptor signaling pathway|positive regulation of cell-cell adhesion|negative regulation of cell migration|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of activin receptor signaling pathway|negative regulation of peptidyl-serine phosphorylation|adherens junction assembly|response to laminar fluid shear stress|cellular protein complex localization|type I transforming growth factor beta receptor binding|protein complex|negative regulation of DNA binding transcription factor activity|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|activin binding|artery morphogenesis|protein stabilization|negative regulation of ubiquitin-protein transferase activity|ventricular cardiac muscle tissue morphogenesis|regulation of cardiac muscle contraction|regulation of ventricular cardiac muscle cell membrane depolarization|pathway-restricted SMAD protein phosphorylation|negative regulation of pathway-restricted SMAD protein phosphorylation|ventricular septum morphogenesis|I-SMAD binding|cellular response to transforming growth factor beta stimulus|cellular response to leukemia inhibitory factor|negative regulation of T-helper 17 type immune response|negative regulation of T-helper 17 cell differentiation hsa04350,hsa04390 TGF-beta signaling pathway|Hippo signaling pathway SMAD9 35.1716781772196 36.4181542231528 33.9252021312864 0.931546445857997 -0.102300392775176 0.895325830848103 1 0.185823 0.111683 0.15971 0.122434 GeneID:4093,Genbank:NM_005905.5,HGNC:HGNC:6774,MIM:603295 SMAD family member 9 GO:0001657,GO:0003677,GO:0003700,GO:0005622,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006351,GO:0006468,GO:0007179,GO:0030509,GO:0030618,GO:0030901,GO:0030902,GO:0046872,GO:0051216,GO:0060348,GO:0060395,GO:0071141,GO:0071407,GO:0071773,GO:1901522 ureteric bud development|DNA binding|DNA binding transcription factor activity|intracellular|nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytosol|transcription, DNA-templated|protein phosphorylation|transforming growth factor beta receptor signaling pathway|BMP signaling pathway|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|midbrain development|hindbrain development|metal ion binding|cartilage development|bone development|SMAD protein signal transduction|SMAD protein complex|cellular response to organic cyclic compound|cellular response to BMP stimulus|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus hsa04350,hsa04550 TGF-beta signaling pathway|Signaling pathways regulating pluripotency of stem cells SMAGP 465.093937688906 455.259404757298 474.928470620514 1.04320408465521 0.0610214235507646 0.79269143548202 1 9.99612 12.8678 12.4829 13.1813 GeneID:57228,Genbank:NM_001031628.1,HGNC:HGNC:26918 small cell adhesion glycoprotein GO:0004872,GO:0005102,GO:0005654,GO:0005886,GO:0005887,GO:0005913,GO:0007156,GO:0007157,GO:0008037,GO:0030054,GO:0030659,GO:0042803,GO:0050839 receptor activity|receptor binding|nucleoplasm|plasma membrane|integral component of plasma membrane|cell-cell adherens junction|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell recognition|cell junction|cytoplasmic vesicle membrane|protein homodimerization activity|cell adhesion molecule binding SMAP1 631.317203885984 634.524400320049 628.11000745192 0.989891022528221 -0.014658387788105 0.951554198541754 1 3.86678 3.82547 3.89259 3.29903 GeneID:60682,Genbank:NM_001044305.2,HGNC:HGNC:19651,MIM:611372 small ArfGAP 1 hsa04144 Endocytosis SMAP2 905.353837734884 899.120671754029 911.587003715739 1.01386502652352 0.0198656025125756 0.911253639197607 1 9.22543 9.72901 10.0498 9.53497 GeneID:64744,Genbank:XM_024449134.1,HGNC:HGNC:25082,MIM:616916 small ArfGAP2 GO:0005096,GO:0005737,GO:0046872 GTPase activator activity|cytoplasm|metal ion binding hsa04144 Endocytosis SMARCA1 875.490925508359 897.484727412176 853.497123604541 0.950987908246116 -0.072501097465317 0.756125960518647 1 6.80334 5.58996 6.72753 5.2301 GeneID:6594,Genbank:XM_005262461.2,HGNC:HGNC:11097,MIM:300012 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 GO:0003677,GO:0004386,GO:0005524,GO:0005634,GO:0005654,GO:0006338,GO:0006351,GO:0007420,GO:0008134,GO:0016569,GO:0016589,GO:0016887,GO:0030182,GO:0031491,GO:0036310,GO:0043044,GO:0043231,GO:0045893,GO:0090537 DNA binding|helicase activity|ATP binding|nucleus|nucleoplasm|chromatin remodeling|transcription, DNA-templated|brain development|transcription factor binding|covalent chromatin modification|NURF complex|ATPase activity|neuron differentiation|nucleosome binding|annealing helicase activity|ATP-dependent chromatin remodeling|intracellular membrane-bounded organelle|positive regulation of transcription, DNA-templated|CERF complex SMARCA2 1110.74489306481 1065.61540190142 1155.87438422819 1.0847012741799 0.117297780367244 0.421722105526447 1 4.48281 4.04733 4.89271 4.34398 GeneID:6595,Genbank:NM_003070.4,HGNC:HGNC:11098,MIM:600014 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 GO:0000790,GO:0001105,GO:0004386,GO:0005524,GO:0005634,GO:0005654,GO:0006325,GO:0006334,GO:0006338,GO:0007399,GO:0008285,GO:0016514,GO:0016887,GO:0030308,GO:0035887,GO:0042393,GO:0043231,GO:0044212,GO:0045111,GO:0045892,GO:0045893,GO:0045944,GO:0071564,GO:0071565 nuclear chromatin|RNA polymerase II transcription coactivator activity|helicase activity|ATP binding|nucleus|nucleoplasm|chromatin organization|nucleosome assembly|chromatin remodeling|nervous system development|negative regulation of cell proliferation|SWI/SNF complex|ATPase activity|negative regulation of cell growth|aortic smooth muscle cell differentiation|histone binding|intracellular membrane-bounded organelle|transcription regulatory region DNA binding|intermediate filament cytoskeleton|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|npBAF complex|nBAF complex hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma SMARCA4 5253.89683967496 5049.43170790321 5458.36197144672 1.08098540334816 0.112347042351559 0.404751156539756 1 24.5173 24.5738 27.6902 26.5827 GeneID:6597,Genbank:NM_001128844.1,HGNC:HGNC:11100,MIM:603254 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma SMARCA5 921.186482731363 988.788844652844 853.584120809881 0.86326228843082 -0.212129129078874 0.591114363028646 1 5.47845 4.04351 5.09042 3.19579 GeneID:8467,Genbank:NM_003601.3,HGNC:HGNC:11101,MIM:603375 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 GO:0000183,GO:0000793,GO:0001650,GO:0003677,GO:0004386,GO:0005524,GO:0005634,GO:0005654,GO:0005677,GO:0006334,GO:0006338,GO:0006352,GO:0006357,GO:0016569,GO:0016584,GO:0016589,GO:0016887,GO:0031213,GO:0031491,GO:0034080,GO:0043044,GO:0045815,GO:0045893,GO:1990830 chromatin silencing at rDNA|condensed chromosome|fibrillar center|DNA binding|helicase activity|ATP binding|nucleus|nucleoplasm|chromatin silencing complex|nucleosome assembly|chromatin remodeling|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|covalent chromatin modification|nucleosome positioning|NURF complex|ATPase activity|RSF complex|nucleosome binding|CENP-A containing nucleosome assembly|ATP-dependent chromatin remodeling|positive regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|cellular response to leukemia inhibitory factor SMARCAD1 238.481313175224 248.681629851318 228.28099649913 0.917964855850491 -0.12348917355848 0.758601357787025 1 1.72521 1.19422 1.41279 1.19016 GeneID:56916,Genbank:NM_001128430.1,HGNC:HGNC:18398,MIM:612761 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 hsa04550 Signaling pathways regulating pluripotency of stem cells SMARCAL1 428.373716470681 403.139348361294 453.608084580067 1.12518930842132 0.170167749303805 0.366170844737697 1 3.74272 4.57345 4.73373 4.67804 GeneID:50485,Genbank:NM_014140.3,HGNC:HGNC:11102,MIM:606622 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 SMARCB1 2352.61916855614 2356.74008394238 2348.49825316991 0.996502868165809 -0.00505413740693899 0.958575659511128 1 36.791 36.9441 38.4193 37.0746 GeneID:6598,Genbank:NM_003073.4,HGNC:HGNC:11103,MIM:601607 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 GO:0001164,GO:0001650,GO:0001741,GO:0001824,GO:0001835,GO:0002039,GO:0003677,GO:0003713,GO:0005634,GO:0005654,GO:0005730,GO:0006281,GO:0006337,GO:0006338,GO:0006351,GO:0006357,GO:0007049,GO:0007399,GO:0008285,GO:0016514,GO:0016569,GO:0030154,GO:0030957,GO:0039692,GO:0043044,GO:0043231,GO:0043923,GO:0045944,GO:0051091,GO:0071564,GO:0071565,GO:0090240,GO:1900110,GO:1900113,GO:1901838,GO:1902661,GO:2000617 RNA polymerase I CORE element sequence-specific DNA binding|fibrillar center|XY body|blastocyst development|blastocyst hatching|p53 binding|DNA binding|transcription coactivator activity|nucleus|nucleoplasm|nucleolus|DNA repair|nucleosome disassembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|cell cycle|nervous system development|negative regulation of cell proliferation|SWI/SNF complex|covalent chromatin modification|cell differentiation|Tat protein binding|single stranded viral RNA replication via double stranded DNA intermediate|ATP-dependent chromatin remodeling|intracellular membrane-bounded organelle|positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter|positive regulation of DNA binding transcription factor activity|npBAF complex|nBAF complex|positive regulation of histone H4 acetylation|negative regulation of histone H3-K9 dimethylation|negative regulation of histone H3-K9 trimethylation|positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|positive regulation of glucose mediated signaling pathway|positive regulation of histone H3-K9 acetylation hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma SMARCC1 3503.42711186231 3599.74542269213 3407.1088010325 0.946486043028131 -0.0793468629177706 0.570452470787684 1 18.8632 17.8372 18.9867 16.0727 GeneID:6599,Genbank:NM_003074.3,HGNC:HGNC:11104,MIM:601732 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 GO:0000790,GO:0001741,GO:0003677,GO:0003682,GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0006337,GO:0006338,GO:0006351,GO:0006357,GO:0007399,GO:0008286,GO:0009887,GO:0016514,GO:0016569,GO:0030850,GO:0032435,GO:0043044,GO:0043234,GO:0045893,GO:0045944,GO:0047485,GO:0071564,GO:0071565 nuclear chromatin|XY body|DNA binding|chromatin binding|transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|nucleosome disassembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|nervous system development|insulin receptor signaling pathway|animal organ morphogenesis|SWI/SNF complex|covalent chromatin modification|prostate gland development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|ATP-dependent chromatin remodeling|protein complex|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein N-terminus binding|npBAF complex|nBAF complex hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma SMARCC2 2728.3215574004 2666.6600047273 2789.98311007351 1.04624628003855 0.0652224932372868 0.637406893368256 1 13.2154 13.2613 14.3202 13.6011 GeneID:6601,Genbank:NM_003075.4,HGNC:HGNC:11105,MIM:601734 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 GO:0000790,GO:0003677,GO:0003713,GO:0005654,GO:0006337,GO:0006338,GO:0006351,GO:0006357,GO:0007399,GO:0016514,GO:0016569,GO:0043044,GO:0043234,GO:0045892,GO:0045893,GO:0071564,GO:0071565 nuclear chromatin|DNA binding|transcription coactivator activity|nucleoplasm|nucleosome disassembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|nervous system development|SWI/SNF complex|covalent chromatin modification|ATP-dependent chromatin remodeling|protein complex|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|npBAF complex|nBAF complex hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma SMARCD1 1641.62155271027 1537.62347821953 1745.619627201 1.13527118434893 0.183036957942594 0.20229128416336 1 15.0834 14.8667 17.5432 17.4132 GeneID:6602,Genbank:NM_003076.4,HGNC:HGNC:11106,MIM:601735 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 GO:0003682,GO:0003713,GO:0005102,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0007399,GO:0016514,GO:0016569,GO:0032947,GO:0043231,GO:0048096,GO:0071398,GO:0071564,GO:0071565 chromatin binding|transcription coactivator activity|receptor binding|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription from RNA polymerase II promoter|nervous system development|SWI/SNF complex|covalent chromatin modification|protein complex scaffold activity|intracellular membrane-bounded organelle|chromatin-mediated maintenance of transcription|cellular response to fatty acid|npBAF complex|nBAF complex hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma SMARCD2 1546.84812453256 1642.28601882859 1451.41023023653 0.883774332604856 -0.178250063273565 0.212780962772764 1 21.8121 22.0081 19.46 20.452 GeneID:6603,Genbank:NM_001098426.1,HGNC:HGNC:11107,MIM:601736 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 GO:0000790,GO:0003713,GO:0005654,GO:0006337,GO:0006338,GO:0006351,GO:0006357,GO:0016514,GO:0016569,GO:0043044,GO:0043234 nuclear chromatin|transcription coactivator activity|nucleoplasm|nucleosome disassembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|SWI/SNF complex|covalent chromatin modification|ATP-dependent chromatin remodeling|protein complex hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma SMARCD3 272.296566883753 287.292426402326 257.300707365181 0.895605605018126 -0.159064537770377 0.570960287941837 1 2.81321 3.1215 2.29555 3.11303 GeneID:6604,Genbank:XM_024446887.1,HGNC:HGNC:11108,MIM:601737 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 GO:0000790,GO:0002052,GO:0003139,GO:0003219,GO:0003407,GO:0003682,GO:0003713,GO:0005102,GO:0005634,GO:0005654,GO:0005737,GO:0006337,GO:0006338,GO:0006351,GO:0006357,GO:0008134,GO:0010971,GO:0016514,GO:0016569,GO:0016922,GO:0019216,GO:0030374,GO:0035257,GO:0042692,GO:0043393,GO:0045893,GO:0051152,GO:0071564,GO:0071565 nuclear chromatin|positive regulation of neuroblast proliferation|secondary heart field specification|cardiac right ventricle formation|neural retina development|chromatin binding|transcription coactivator activity|receptor binding|nucleus|nucleoplasm|cytoplasm|nucleosome disassembly|chromatin remodeling|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription factor binding|positive regulation of G2/M transition of mitotic cell cycle|SWI/SNF complex|covalent chromatin modification|ligand-dependent nuclear receptor binding|regulation of lipid metabolic process|ligand-dependent nuclear receptor transcription coactivator activity|nuclear hormone receptor binding|muscle cell differentiation|regulation of protein binding|positive regulation of transcription, DNA-templated|positive regulation of smooth muscle cell differentiation|npBAF complex|nBAF complex hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma SMARCE1 1910.08900580941 1821.05992598853 1999.11808563029 1.09777721045896 0.134585294799391 0.326074988375789 1 24.2452 21.7207 26.1349 24.2183 GeneID:6605,Genbank:NM_003079.4,HGNC:HGNC:11109,MIM:603111 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 GO:0000228,GO:0000790,GO:0003677,GO:0003682,GO:0003713,GO:0003723,GO:0005634,GO:0005654,GO:0006337,GO:0006338,GO:0006357,GO:0008080,GO:0016514,GO:0016569,GO:0016922,GO:0017053,GO:0022008,GO:0043044,GO:0043234,GO:0045892,GO:0047485,GO:0071564,GO:0071565 nuclear chromosome|nuclear chromatin|DNA binding|chromatin binding|transcription coactivator activity|RNA binding|nucleus|nucleoplasm|nucleosome disassembly|chromatin remodeling|regulation of transcription from RNA polymerase II promoter|N-acetyltransferase activity|SWI/SNF complex|covalent chromatin modification|ligand-dependent nuclear receptor binding|transcriptional repressor complex|neurogenesis|ATP-dependent chromatin remodeling|protein complex|negative regulation of transcription, DNA-templated|protein N-terminus binding|npBAF complex|nBAF complex hsa04714,hsa05225 Thermogenesis|Hepatocellular carcinoma SMC1A 3398.04047849887 3435.36384863087 3360.71710836686 0.978271081738908 -0.0316937993524431 0.827602162407638 1 9.95118 9.61127 11.0083 8.50906 GeneID:8243,Genbank:NM_006306.3,HGNC:HGNC:11111,MIM:300040 structural maintenance of chromosomes 1A GO:0000070,GO:0000775,GO:0000776,GO:0000777,GO:0000794,GO:0003682,GO:0003723,GO:0005524,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006281,GO:0007062,GO:0007064,GO:0008278,GO:0009314,GO:0016363,GO:0019827,GO:0030893,GO:0032876,GO:0036033,GO:0046982,GO:0051301,GO:0051321,GO:0072423,GO:0097431,GO:1901673 mitotic sister chromatid segregation|chromosome, centromeric region|kinetochore|condensed chromosome kinetochore|condensed nuclear chromosome|chromatin binding|RNA binding|ATP binding|nucleus|nucleoplasm|chromosome|cytosol|DNA repair|sister chromatid cohesion|mitotic sister chromatid cohesion|cohesin complex|response to radiation|nuclear matrix|stem cell population maintenance|meiotic cohesin complex|negative regulation of DNA endoreduplication|mediator complex binding|protein heterodimerization activity|cell division|meiotic cell cycle|response to DNA damage checkpoint signaling|mitotic spindle pole|regulation of mitotic spindle assembly hsa04110,hsa04114 Cell cycle|Oocyte meiosis SMC1B 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:27127,Genbank:NM_001291501.1,HGNC:HGNC:11112,MIM:608685 structural maintenance of chromosomes 1B GO:0000775,GO:0000800,GO:0003677,GO:0005524,GO:0005654,GO:0005829,GO:0007062,GO:0030893,GO:0034991,GO:0051321 chromosome, centromeric region|lateral element|DNA binding|ATP binding|nucleoplasm|cytosol|sister chromatid cohesion|meiotic cohesin complex|nuclear meiotic cohesin complex|meiotic cell cycle hsa04110,hsa04114 Cell cycle|Oocyte meiosis SMC2 353.305152892352 343.052671019278 363.557634765426 1.05977205682505 0.0837539932304368 0.8266516131013 1 1.29046 1.18682 1.79001 0.996901 GeneID:10592,Genbank:XM_011518149.3,HGNC:HGNC:14011,MIM:605576 structural maintenance of chromosomes 2 GO:0000228,GO:0000793,GO:0000796,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0007076,GO:0010032,GO:0045132,GO:0046982,GO:0051301,GO:0051383,GO:0070062 nuclear chromosome|condensed chromosome|condensin complex|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|mitotic chromosome condensation|meiotic chromosome condensation|meiotic chromosome segregation|protein heterodimerization activity|cell division|kinetochore organization|extracellular exosome SMC3 372.287612363061 390.242587430385 354.332637295736 0.907980442700773 -0.13926687173513 0.691323397528254 1 2.79447 2.41495 3.0514 1.84836 GeneID:9126,Genbank:NM_005445.3,HGNC:HGNC:2468,MIM:606062 structural maintenance of chromosomes 3 GO:0000278,GO:0000775,GO:0000785,GO:0000800,GO:0003682,GO:0003777,GO:0005524,GO:0005604,GO:0005622,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006275,GO:0006281,GO:0007062,GO:0008278,GO:0016363,GO:0019827,GO:0030893,GO:0032876,GO:0034991,GO:0036033,GO:0044791,GO:0046982,GO:0048487,GO:0051301,GO:0051321,GO:0051702,GO:0070840,GO:0097431,GO:1901673 mitotic cell cycle|chromosome, centromeric region|chromatin|lateral element|chromatin binding|microtubule motor activity|ATP binding|basement membrane|intracellular|nucleus|nucleoplasm|chromosome|cytosol|regulation of DNA replication|DNA repair|sister chromatid cohesion|cohesin complex|nuclear matrix|stem cell population maintenance|meiotic cohesin complex|negative regulation of DNA endoreduplication|nuclear meiotic cohesin complex|mediator complex binding|positive regulation by host of viral release from host cell|protein heterodimerization activity|beta-tubulin binding|cell division|meiotic cell cycle|interaction with symbiont|dynein complex binding|mitotic spindle pole|regulation of mitotic spindle assembly hsa04110,hsa04114 Cell cycle|Oocyte meiosis SMC4 1440.91831014818 1487.23033371047 1394.60628658589 0.937720442472754 -0.0927702109222716 0.829670071619866 1 8.64147 7.21236 9.61005 5.35336 GeneID:10051,Genbank:NM_001002800.2,HGNC:HGNC:14013,MIM:605575 structural maintenance of chromosomes 4 GO:0000070,GO:0000796,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0007076,GO:0010032,GO:0016607,GO:0045132,GO:0046982,GO:0051301,GO:0051383 mitotic sister chromatid segregation|condensin complex|ATP binding|nucleus|nucleoplasm|cytosol|mitotic chromosome condensation|meiotic chromosome condensation|nuclear speck|meiotic chromosome segregation|protein heterodimerization activity|cell division|kinetochore organization SMC5 194.133740844678 194.852244876871 193.415236812485 0.992625139806346 -0.0106791012490497 0.999816170218785 1 1.00562 0.845003 1.1983 0.612623 GeneID:23137,Genbank:NM_015110.3,HGNC:HGNC:20465,MIM:609386 structural maintenance of chromosomes 5 GO:0000722,GO:0000724,GO:0000781,GO:0000803,GO:0005524,GO:0005634,GO:0005654,GO:0006974,GO:0007062,GO:0016605,GO:0016607,GO:0030054,GO:0030915,GO:0034184,GO:0035061,GO:0035861,GO:0051301,GO:0051984,GO:0090398 telomere maintenance via recombination|double-strand break repair via homologous recombination|chromosome, telomeric region|sex chromosome|ATP binding|nucleus|nucleoplasm|cellular response to DNA damage stimulus|sister chromatid cohesion|PML body|nuclear speck|cell junction|Smc5-Smc6 complex|positive regulation of maintenance of mitotic sister chromatid cohesion|interchromatin granule|site of double-strand break|cell division|positive regulation of chromosome segregation|cellular senescence SMC6 138.763701449197 130.173645474462 147.353757423932 1.13197841918655 0.178846453903603 0.608063553351615 1 0.648601 0.537128 0.882027 0.552316 GeneID:79677,Genbank:XM_017004916.2,HGNC:HGNC:20466,MIM:609387 structural maintenance of chromosomes 6 GO:0000722,GO:0000724,GO:0000781,GO:0000803,GO:0005524,GO:0005622,GO:0005634,GO:0005654,GO:0006974,GO:0016605,GO:0016607,GO:0030915,GO:0031625,GO:0035061,GO:0035861,GO:0051984,GO:0090398 telomere maintenance via recombination|double-strand break repair via homologous recombination|chromosome, telomeric region|sex chromosome|ATP binding|intracellular|nucleus|nucleoplasm|cellular response to DNA damage stimulus|PML body|nuclear speck|Smc5-Smc6 complex|ubiquitin protein ligase binding|interchromatin granule|site of double-strand break|positive regulation of chromosome segregation|cellular senescence SMCHD1 620.281902303333 580.808651203479 659.755153403187 1.1359251485599 0.183867772026338 0.694698287912318 1 1.95549 1.54766 2.64769 1.34126 GeneID:23347,Genbank:XM_017025684.1,HGNC:HGNC:29090,MIM:614982 structural maintenance of chromosomes flexible hinge domain containing 1 GO:0001740,GO:0005524,GO:0016887,GO:0043584,GO:0051276,GO:0060821 Barr body|ATP binding|ATPase activity|nose development|chromosome organization|inactivation of X chromosome by DNA methylation SMCO1 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0496312 GeneID:255798,Genbank:NM_001077657.2,HGNC:HGNC:27407 single-pass membrane protein with coiled-coil domains 1 GO:0016021 integral component of membrane SMCO2 4.49894976400067 3.18055978516888 5.81733974283245 1.82903015059142 0.871078857344801 0.570484411104223 1 0.0260299 0.00627637 0.0376516 0.0175281 GeneID:341346,Genbank:XM_011520634.2,HGNC:HGNC:34448 single-pass membrane protein with coiled-coil domains 2 GO:0016021 integral component of membrane SMCO4 150.55901780929 141.685419092906 159.432616525674 1.12525775444212 0.170255506742254 0.491144888716633 1 1.01066 0.936263 1.17136 1.22123 GeneID:56935,Genbank:XM_011542909.1,HGNC:HGNC:24810,MIM:609477 single-pass membrane protein with coiled-coil domains 4 GO:0005786,GO:0006614,GO:0008312,GO:0030942 signal recognition particle, endoplasmic reticulum targeting|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|endoplasmic reticulum signal peptide binding SMCR8 1626.90373747032 1598.23742758222 1655.57004735842 1.03587240467952 0.0508463075873264 0.725760145696507 1 7.30691 7.26341 8.31343 7.10669 GeneID:140775,Genbank:NM_144775.2,HGNC:HGNC:17921,MIM:617074 Smith-Magenis syndrome chromosome region, candidate 8 GO:0000785,GO:0004860,GO:0005085,GO:0005654,GO:0005737,GO:0006351,GO:0006355,GO:0006469,GO:0006914,GO:0010506,GO:0010629,GO:0016242,GO:0019901,GO:0032008,GO:0032045,GO:1901098,GO:1902902,GO:1903432,GO:1990316 chromatin|protein kinase inhibitor activity|guanyl-nucleotide exchange factor activity|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of protein kinase activity|autophagy|regulation of autophagy|negative regulation of gene expression|negative regulation of macroautophagy|protein kinase binding|positive regulation of TOR signaling|guanyl-nucleotide exchange factor complex|positive regulation of autophagosome maturation|negative regulation of autophagosome assembly|regulation of TORC1 signaling|Atg1/ULK1 kinase complex SMDT1 508.157538955681 506.05230877063 510.262769140732 1.00832020780684 0.0119538619088223 0.971081268209963 1 14.1057 16.9026 14.0428 16.9247 GeneID:91689,Genbank:NM_033318.4,HGNC:HGNC:25055,MIM:615588 single-pass membrane protein with aspartate rich tail 1 GO:0005634,GO:0005739,GO:0005743,GO:0005759,GO:0006851,GO:0031305,GO:0036444,GO:0051560,GO:1990246 nucleus|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|mitochondrial calcium ion transmembrane transport|integral component of mitochondrial inner membrane|mitochondrial calcium uptake|mitochondrial calcium ion homeostasis|uniplex complex SMG1 781.689445186595 794.005260361728 769.373630011461 0.968978001053739 -0.0454641827361169 0.94524572123456 1 1.91422 1.60152 2.37742 1.00452 GeneID:23049,Genbank:NM_015092.4,HGNC:HGNC:30045,MIM:607032 SMG1, nonsense mediated mRNA decay associated PI3K related kinase GO:0000184,GO:0003723,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006406,GO:0006950,GO:0018105,GO:0032204,GO:0042162,GO:0046777,GO:0046854,GO:0046872 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|mRNA export from nucleus|response to stress|peptidyl-serine phosphorylation|regulation of telomere maintenance|telomeric DNA binding|protein autophosphorylation|phosphatidylinositol phosphorylation|metal ion binding hsa03015 mRNA surveillance pathway SMG5 5739.8202532309 5476.54633734083 6003.09416912096 1.09614596487387 0.132439923096121 0.325879160331719 1 38.4152 39.9033 44.876 42.9072 GeneID:23381,Genbank:NM_001323617.1,HGNC:HGNC:24644,MIM:610962 SMG5, nonsense mediated mRNA decay factor GO:0000184,GO:0004540,GO:0005634,GO:0005697,GO:0005737,GO:0005829,GO:0006406,GO:0031625,GO:0032204,GO:0032210,GO:0035303,GO:0042162,GO:0042826,GO:0043021,GO:0043487,GO:0051721,GO:0070034,GO:0070182 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|ribonuclease activity|nucleus|telomerase holoenzyme complex|cytoplasm|cytosol|mRNA export from nucleus|ubiquitin protein ligase binding|regulation of telomere maintenance|regulation of telomere maintenance via telomerase|regulation of dephosphorylation|telomeric DNA binding|histone deacetylase binding|ribonucleoprotein complex binding|regulation of RNA stability|protein phosphatase 2A binding|telomerase RNA binding|DNA polymerase binding hsa03015 mRNA surveillance pathway SMG6 1164.35911502805 1200.04681951519 1128.67141054091 0.940522813098979 -0.0884651570446829 0.562404138527493 1 2.96474 2.86131 2.74227 2.85049 GeneID:23293,Genbank:NM_017575.4,HGNC:HGNC:17809,MIM:610963 SMG6, nonsense mediated mRNA decay factor GO:0000184,GO:0000781,GO:0003723,GO:0004521,GO:0005634,GO:0005697,GO:0005730,GO:0005737,GO:0005829,GO:0006406,GO:0032204,GO:0032210,GO:0035303,GO:0042162,GO:0043021,GO:0043487,GO:0046872,GO:0051972,GO:0070034,GO:0070182,GO:1904354 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|chromosome, telomeric region|RNA binding|endoribonuclease activity|nucleus|telomerase holoenzyme complex|nucleolus|cytoplasm|cytosol|mRNA export from nucleus|regulation of telomere maintenance|regulation of telomere maintenance via telomerase|regulation of dephosphorylation|telomeric DNA binding|ribonucleoprotein complex binding|regulation of RNA stability|metal ion binding|regulation of telomerase activity|telomerase RNA binding|DNA polymerase binding|negative regulation of telomere capping hsa03015 mRNA surveillance pathway SMG7 2539.1392065854 2402.05494163906 2676.22347153173 1.11413915857627 0.155929439903672 0.258791303150882 1 10.7444 10.6617 13.0013 11.3672 GeneID:9887,Genbank:XM_011510205.3,HGNC:HGNC:16792,MIM:610964 SMG7, nonsense mediated mRNA decay factor GO:0000184,GO:0004540,GO:0005634,GO:0005697,GO:0005737,GO:0005829,GO:0006406,GO:0007004,GO:0035303,GO:0042162,GO:0043021,GO:0043487,GO:0045111,GO:0051721,GO:0070034 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|ribonuclease activity|nucleus|telomerase holoenzyme complex|cytoplasm|cytosol|mRNA export from nucleus|telomere maintenance via telomerase|regulation of dephosphorylation|telomeric DNA binding|ribonucleoprotein complex binding|regulation of RNA stability|intermediate filament cytoskeleton|protein phosphatase 2A binding|telomerase RNA binding hsa03015 mRNA surveillance pathway SMG8 913.070982832544 894.700220481304 931.441745183784 1.04106573784313 0.0580611701415688 0.713733763967363 1 10.2628 10.6351 11.0383 10.8126 GeneID:55181,Genbank:NM_018149.6,HGNC:HGNC:25551,MIM:613175 SMG8, nonsense mediated mRNA decay factor GO:0000184,GO:0005829,GO:0045859 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|cytosol|regulation of protein kinase activity SMG9 1847.99069974492 1819.49772723671 1876.48367225313 1.03131960219756 0.0444914879468279 0.777362888175409 1 9.67377 10.5216 10.8828 10.1481 GeneID:56006,Genbank:XM_005259057.3,HGNC:HGNC:25763,MIM:613176 SMG9, nonsense mediated mRNA decay factor GO:0000184,GO:0001654,GO:0005622,GO:0005829,GO:0007420,GO:0007507,GO:0042802 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|eye development|intracellular|cytosol|brain development|heart development|identical protein binding SMIM1 1.02273099320278 1.07619535328461 0.969266633120943 0.900641904987498 -0.150974490057726 1 1 0 0 0.114124 0.106605 GeneID:388588,Genbank:NM_001288583.1,HGNC:HGNC:44204,MIM:615242 small integral membrane protein 1 (Vel blood group) SMIM10 249.10788788824 276.251106875624 221.964668900856 0.80348879471021 -0.315650190375586 0.135018456090299 1 6.85673 7.46476 6.04152 5.41845 GeneID:644538,Genbank:NM_001163438.1,HGNC:HGNC:41913 small integral membrane protein 10 GO:0016021 integral component of membrane SMIM10L1 540.67511034124 515.79488487913 565.555335803349 1.09647333151797 0.132870723133574 0.427507370959775 1 4.68167 4.52876 5.10041 4.95941 GeneID:100129361,Genbank:NM_001271592.1,HGNC:HGNC:49847 small integral membrane protein 10 like 1 SMIM10L2A 74.6428968858643 62.0361372938825 87.249656477846 1.40643277102377 0.492040591949653 0.159103254089776 1 0.455021 0.455631 0.786426 0.496962 GeneID:399668,Genbank:NM_203306.2,HGNC:HGNC:34499 small integral membrane protein 10 like 2A SMIM10L2B 23.3550666911359 21.9855695031805 24.7245638790913 1.12458146128599 0.169388169374227 0.819457291401462 1 0.290451 0.307916 0.398883 0.186615 GeneID:644596,Genbank:NM_001348255.1,HGNC:HGNC:34500 small integral membrane protein 10 like 2B SMIM11A 5.58221478031387 6.80316469761019 4.36126486301754 0.641064130719864 -0.641459406618143 0.67987480797864 1 0.116223 0.0400807 0.0413338 0.0385752 GeneID:54065,Genbank:NM_058182.4,HGNC:HGNC:1293 small integral membrane protein 11A GO:0016021 integral component of membrane SMIM11B 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.0115208 0 0.021817 0 GeneID:102723553,Genbank:NM_001313692.1,HGNC:HGNC:51846 small integral membrane protein 11B GO:0016021 integral component of membrane SMIM12 986.079978360129 983.085560622153 989.074396098104 1.00609187614571 0.0087620578347187 0.98379595786002 1 5.14119 5.99355 5.51622 5.86424 GeneID:113444,Genbank:NM_138428.5,HGNC:HGNC:25154 small integral membrane protein 12 GO:0016021 integral component of membrane SMIM13 852.183978676578 951.641504655164 752.726452697992 0.790976905710675 -0.338292522190653 0.175439027000263 1 10.8872 9.35299 9.52149 6.64022 GeneID:221710,Genbank:NM_001135575.1,HGNC:HGNC:27356 small integral membrane protein 13 GO:0016021 integral component of membrane SMIM14 1024.95050962405 994.806005646989 1055.09501360111 1.06060378366424 0.0848858003609598 0.557469446540284 1 7.76841 6.73568 8.59642 7.02246 GeneID:201895,Genbank:NM_174921.2,HGNC:HGNC:27321 small integral membrane protein 14 GO:0005783,GO:0005789,GO:0016021 endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane SMIM15 1113.92386142685 1173.69761666822 1054.15010618548 0.89814454013965 -0.154980455530709 0.340739922777901 1 20.6012 18.8202 20.0206 15.7995 GeneID:643155,Genbank:NM_001048249.3,HGNC:HGNC:33861 small integral membrane protein 15 GO:0016021 integral component of membrane SMIM17 3.4728472490594 1.61429302992691 5.33140146819188 3.30262311077021 1.72361234133198 0.331415754312509 1 0.0298042 0 0.0860348 0.0535048 GeneID:147670,Genbank:XM_017026303.1,HGNC:HGNC:27114 small integral membrane protein 17 GO:0016021 integral component of membrane SMIM18 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.023538 0 GeneID:100507341,Genbank:XM_017012943.1,HGNC:HGNC:42973 small integral membrane protein 18 GO:0016021 integral component of membrane SMIM19 391.610689705013 380.009939919928 403.211439490099 1.06105498075934 0.0854994144183113 0.658894375397806 1 9.07219 9.89382 10.4865 9.78227 GeneID:114926,Genbank:NM_001135676.1,HGNC:HGNC:25166 small integral membrane protein 19 GO:0016021 integral component of membrane SMIM2 0.996216306175209 0.538097676642304 1.45433493570811 2.70273409241064 1.43441957978558 0.835201184388344 1 0 0 0 0 GeneID:79024,Genbank:NM_024058.2,HGNC:HGNC:28776 small integral membrane protein 2 GO:0016021 integral component of membrane SMIM20 633.115510816767 584.855717934686 681.375303698848 1.16503144759361 0.220368897948243 0.183355568385743 1 27.3864 27.3738 32.7602 32.5313 GeneID:389203,Genbank:NM_001145432.1,HGNC:HGNC:37260,MIM:617465 small integral membrane protein 20 GO:0005743,GO:0016021,GO:0033617 mitochondrial inner membrane|integral component of membrane|mitochondrial respiratory chain complex IV assembly SMIM22 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:440335,Genbank:XM_011522500.2,HGNC:HGNC:48329 small integral membrane protein 22 GO:0016021 integral component of membrane SMIM25 34.1035308254921 35.2459063204983 32.9611553304858 0.935176840985822 -0.0966888919303336 0.897625536262739 1 0.902937 0.53153 0.911421 0.525798 GeneID:100506115,Genbank:XM_006723680.4,HGNC:HGNC:50328 small integral membrane protein 25 SMIM26 570.714432678295 595.311930510916 546.116934845673 0.917362657887568 -0.12443591253495 0.631325519718724 1 25.4509 33.7939 24.7692 28.4196 GeneID:388789,Genbank:NM_001348957.1,HGNC:HGNC:43430 small integral membrane protein 26 GO:0016021 integral component of membrane SMIM27 55.9155355000332 42.5489510751738 69.2821199248926 1.62829207710638 0.703359508202459 0.247738561548031 1 1.26892 1.42537 1.48571 2.792 GeneID:100129250,Genbank:XM_024447368.1,HGNC:HGNC:31420 small integral membrane protein 27 SMIM29 545.267642589205 497.846573452049 592.688711726362 1.19050475253185 0.251573379903038 0.152555906395205 1 16.4911 17.7784 20.3883 19.869 GeneID:221491,Genbank:NM_001008704.2,HGNC:HGNC:1340,MIM:611419 small integral membrane protein 29 GO:0005576 extracellular region SMIM3 1520.76621611276 1465.57622447925 1575.95620774627 1.07531507500147 0.104759441713688 0.486790763296555 1 25.7599 29.1376 29.4002 30.432 GeneID:85027,Genbank:NM_032947.4,HGNC:HGNC:30248,MIM:608324 small integral membrane protein 3 GO:0016021 integral component of membrane SMIM30 837.462084260232 837.987225024052 836.936943496412 0.998746661647963 -0.00180931910655008 0.998200078823818 1 33.122 34.2241 34.7547 34.5279 GeneID:401397,Genbank:NM_001352688.1,HGNC:HGNC:48953 small integral membrane protein 30 GO:0016021 integral component of membrane SMIM32 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:389332,Genbank:NM_001350994.1,HGNC:HGNC:53640 small integral membrane protein 32 SMIM37 345.099207816249 364.549186121356 325.649229511142 0.893292981876896 -0.162794667382403 0.385240587598185 1 5.75793 6.54109 5.33529 5.82571 GeneID:205251,Genbank:NM_001355251.1,HGNC:HGNC:27339 small integral membrane protein 37 GO:0016021 integral component of membrane SMIM4 417.173244914478 380.317714878253 454.028774950703 1.19381442722447 0.255578593947626 0.401243138168437 1 45.901 49.3252 48.9034 63.4941 GeneID:440957,Genbank:XM_011533729.2,HGNC:HGNC:37257 small integral membrane protein 4 GO:0016021 integral component of membrane SMIM5 1.26526514449636 1.07619535328461 1.45433493570811 1.35136704620532 0.434419579785585 1 1 0 0 0.0148484 0 GeneID:643008,Genbank:NM_001162995.2,HGNC:HGNC:40030 small integral membrane protein 5 GO:0016021 integral component of membrane SMIM6 3.41375057148416 3.9205712156589 2.90692992730943 0.741455713315206 -0.431567570904168 0.873611319993804 1 0 0.453292 0 0.125619 GeneID:100130933,Genbank:NM_001162997.1,HGNC:HGNC:40032 small integral membrane protein 6 GO:0016021 integral component of membrane SMIM7 2074.9775937395 2092.22126474841 2057.73392273059 0.983516398289754 -0.0239789879513439 0.855054362586424 1 25.0435 27.3422 27.2396 25.7437 GeneID:79086,Genbank:NM_024104.3,HGNC:HGNC:28419 small integral membrane protein 7 GO:0016021 integral component of membrane SMIM8 114.684948698547 110.148361579111 119.221535817983 1.08237230321719 0.114196827832075 0.665847013779079 1 2.45868 1.58581 2.2327 1.9128 GeneID:57150,Genbank:NM_001042493.2,HGNC:HGNC:21401 small integral membrane protein 8 GO:0016021 integral component of membrane SMKR1 36.443818752648 43.3271801252408 29.5604573800553 0.682261280208135 -0.551603752305054 0.253315607111147 1 1.98181 1.62327 1.20283 1.2823 GeneID:100287482,Genbank:NM_001195243.1,HGNC:HGNC:43561 small lysine rich protein 1 SMN1 272.9239940803 349.589329380704 196.258658779896 0.561397738104786 -0.832904843704509 0.135934428344749 1 2.15608 6.16377 1.65185 1.70576 GeneID:6606,Genbank:NM_000344.3,HGNC:HGNC:11117,MIM:600354 survival of motor neuron 1, telomeric hsa03013 RNA transport SMN2 164.453553165864 182.542624898144 146.364481433583 0.80180988695244 -0.31866788771383 0.429867808933731 1 2.17424 1.55906 1.54766 1.7794 GeneID:6607,Genbank:NM_017411.3,HGNC:HGNC:11118,MIM:601627 survival of motor neuron 2, centromeric hsa03013 RNA transport SMNDC1 1175.90029719994 1280.27241661043 1071.52817778944 0.836953263920465 -0.256781031003854 0.0887153929327661 0.974530681214803 22.6096 22.3161 19.7794 18.5892 GeneID:10285,Genbank:XM_005269382.3,HGNC:HGNC:16900,MIM:603519 survival motor neuron domain containing 1 GO:0000375,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005681,GO:0005737,GO:0006915,GO:0015030,GO:0016607 RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|spliceosomal complex|cytoplasm|apoptotic process|Cajal body|nuclear speck hsa03040 Spliceosome SMO 718.21401397177 660.076773807587 776.351254135953 1.17615296423422 0.23407570166342 0.160205700785761 1 5.98084 6.95767 7.89868 7.80969 GeneID:6608,Genbank:NM_005631.4,HGNC:HGNC:11119,MIM:601500 smoothened, frizzled class receptor GO:0000122,GO:0001570,GO:0001649,GO:0001701,GO:0001708,GO:0001755,GO:0001947,GO:0002052,GO:0002053,GO:0003140,GO:0003323,GO:0004930,GO:0005113,GO:0005886,GO:0005929,GO:0007224,GO:0007228,GO:0007371,GO:0007494,GO:0008144,GO:0009952,GO:0010628,GO:0010629,GO:0016021,GO:0017147,GO:0021542,GO:0021696,GO:0021794,GO:0021904,GO:0021910,GO:0021938,GO:0021953,GO:0021987,GO:0030666,GO:0030857,GO:0031069,GO:0034504,GO:0035264,GO:0040018,GO:0042307,GO:0042475,GO:0043066,GO:0043231,GO:0043392,GO:0045880,GO:0045944,GO:0046622,GO:0048143,GO:0048741,GO:0048853,GO:0048873,GO:0050679,GO:0050821,GO:0051451,GO:0051799,GO:0060170,GO:0060248,GO:0060413,GO:0060644,GO:0060684,GO:0061053,GO:0061113,GO:0070062,GO:0070986,GO:0071397,GO:0072001,GO:0072285,GO:0090190,GO:0097542,GO:2000036,GO:2000826 negative regulation of transcription from RNA polymerase II promoter|vasculogenesis|osteoblast differentiation|in utero embryonic development|cell fate specification|neural crest cell migration|heart looping|positive regulation of neuroblast proliferation|positive regulation of mesenchymal cell proliferation|determination of left/right asymmetry in lateral mesoderm|type B pancreatic cell development|G-protein coupled receptor activity|patched binding|plasma membrane|cilium|smoothened signaling pathway|positive regulation of hh target transcription factor activity|ventral midline determination|midgut development|drug binding|anterior/posterior pattern specification|positive regulation of gene expression|negative regulation of gene expression|integral component of membrane|Wnt-protein binding|dentate gyrus development|cerebellar cortex morphogenesis|thalamus development|dorsal/ventral neural tube patterning|smoothened signaling pathway involved in ventral spinal cord patterning|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|central nervous system neuron differentiation|cerebral cortex development|endocytic vesicle membrane|negative regulation of epithelial cell differentiation|hair follicle morphogenesis|protein localization to nucleus|multicellular organism growth|positive regulation of multicellular organism growth|positive regulation of protein import into nucleus|odontogenesis of dentin-containing tooth|negative regulation of apoptotic process|intracellular membrane-bounded organelle|negative regulation of DNA binding|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of organ growth|astrocyte activation|skeletal muscle fiber development|forebrain morphogenesis|homeostasis of number of cells within a tissue|positive regulation of epithelial cell proliferation|protein stabilization|myoblast migration|negative regulation of hair follicle development|ciliary membrane|detection of cell density by contact stimulus involved in contact inhibition|atrial septum morphogenesis|mammary gland epithelial cell differentiation|epithelial-mesenchymal cell signaling|somite development|pancreas morphogenesis|extracellular exosome|left/right axis specification|cellular response to cholesterol|renal system development|mesenchymal to epithelial transition involved in metanephric renal vesicle formation|positive regulation of branching involved in ureteric bud morphogenesis|ciliary tip|regulation of stem cell population maintenance|regulation of heart morphogenesis hsa04340,hsa04360,hsa05200,hsa05205,hsa05217 Hedgehog signaling pathway|Axon guidance|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma SMOC1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0105457 0 0 GeneID:64093,Genbank:XM_005267995.1,HGNC:HGNC:20318,MIM:608488 SPARC related modular calcium binding 1 GO:0001654,GO:0005509,GO:0005604,GO:0007165,GO:0030154,GO:0045667,GO:0050840,GO:0060173 eye development|calcium ion binding|basement membrane|signal transduction|cell differentiation|regulation of osteoblast differentiation|extracellular matrix binding|limb development SMOX 579.634280983601 585.472284852192 573.796277115011 0.980057112797185 -0.0290622702019637 0.858171832476762 1 6.94881 8.70048 7.57903 7.65799 GeneID:54498,Genbank:NM_001270691.1,HGNC:HGNC:15862,MIM:615854 spermine oxidase GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006596,GO:0006598,GO:0031965,GO:0043231,GO:0046208,GO:0046592,GO:0052894,GO:0052895,GO:0052901 nucleus|nucleoplasm|cytoplasm|cytosol|polyamine biosynthetic process|polyamine catabolic process|nuclear membrane|intracellular membrane-bounded organelle|spermine catabolic process|polyamine oxidase activity|norspermine:oxygen oxidoreductase activity|N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity|spermine:oxygen oxidoreductase (spermidine-forming) activity hsa00330,hsa00410 Arginine and proline metabolism|beta-Alanine metabolism SMPD1 1606.0005868453 1475.12669548901 1736.87447820158 1.17744088254453 0.23565462620672 0.103404667512569 1 19.8993 19.6838 23.7211 24.4519 GeneID:6609,Genbank:NM_001318088.1,HGNC:HGNC:11120,MIM:607608 sphingomyelin phosphodiesterase 1 hsa00600,hsa04071,hsa04142,hsa04217 Sphingolipid metabolism|Sphingolipid signaling pathway|Lysosome|Necroptosis SMPD2 398.106945208329 411.441136229245 384.772754187412 0.935182995345964 -0.0966793976451335 0.598828883065715 1 6.03305 5.72445 5.45421 5.42775 GeneID:6610,Genbank:XM_024446526.1,HGNC:HGNC:11121,MIM:603498 sphingomyelin phosphodiesterase 2 GO:0004767,GO:0005622,GO:0005886,GO:0005887,GO:0005901,GO:0006684,GO:0006687,GO:0009612,GO:0035556,GO:0046513,GO:0046872,GO:2000304 sphingomyelin phosphodiesterase activity|intracellular|plasma membrane|integral component of plasma membrane|caveola|sphingomyelin metabolic process|glycosphingolipid metabolic process|response to mechanical stimulus|intracellular signal transduction|ceramide biosynthetic process|metal ion binding|positive regulation of ceramide biosynthetic process hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway SMPD3 3.47828533445629 2.59443583384164 4.36213483507094 1.68134234740808 0.749613509595696 0.714474888626246 1 0.0185419 0.0107858 0.0287322 0.0215128 GeneID:55512,Genbank:XM_017023406.1,HGNC:HGNC:14240,MIM:605777 sphingomyelin phosphodiesterase 3 GO:0000137,GO:0000139,GO:0002244,GO:0004767,GO:0005886,GO:0006685,GO:0006687,GO:0007049,GO:0030072,GO:0046872,GO:1903543,GO:2000304 Golgi cis cisterna|Golgi membrane|hematopoietic progenitor cell differentiation|sphingomyelin phosphodiesterase activity|plasma membrane|sphingomyelin catabolic process|glycosphingolipid metabolic process|cell cycle|peptide hormone secretion|metal ion binding|positive regulation of exosomal secretion|positive regulation of ceramide biosynthetic process hsa00600 Sphingolipid metabolism SMPD4 3288.94048016758 3262.04938747822 3315.83157285693 1.01648723823286 0.0235921025867378 0.87881370188186 1 16.5296 17.6902 18.3492 17.1857 GeneID:55627,Genbank:NM_001171083.2,HGNC:HGNC:32949,MIM:610457 sphingomyelin phosphodiesterase 4 GO:0000139,GO:0004767,GO:0005783,GO:0005789,GO:0005794,GO:0005802,GO:0006685,GO:0006687,GO:0016021,GO:0046475,GO:0046513,GO:0046872,GO:0050290,GO:0071356 Golgi membrane|sphingomyelin phosphodiesterase activity|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|sphingomyelin catabolic process|glycosphingolipid metabolic process|integral component of membrane|glycerophospholipid catabolic process|ceramide biosynthetic process|metal ion binding|sphingomyelin phosphodiesterase D activity|cellular response to tumor necrosis factor hsa00600 Sphingolipid metabolism SMPDL3A 181.833964656824 176.095261433545 187.572667880104 1.06517725890592 0.0910935330473086 0.715700958306681 1 2.26517 1.66489 2.48108 1.88092 GeneID:10924,Genbank:XM_017010204.2,HGNC:HGNC:17389,MIM:610728 sphingomyelin phosphodiesterase acid like 3A GO:0005615,GO:0008081,GO:0008270,GO:0009143,GO:0070062 extracellular space|phosphoric diester hydrolase activity|zinc ion binding|nucleoside triphosphate catabolic process|extracellular exosome SMPDL3B 12.8498028533713 14.5482545795581 11.1513511271845 0.766507835438446 -0.38362755533154 0.722138982532055 1 0.0782171 0.210609 0.14655 0.0113812 GeneID:27293,Genbank:NM_001304579.1,HGNC:HGNC:21416,MIM:617737 sphingomyelin phosphodiesterase acid like 3B GO:0004767,GO:0005615,GO:0005886,GO:0006685,GO:0006954,GO:0008081,GO:0016798,GO:0031225,GO:0034122,GO:0045087,GO:0046466,GO:0046872,GO:0050728,GO:0070062 sphingomyelin phosphodiesterase activity|extracellular space|plasma membrane|sphingomyelin catabolic process|inflammatory response|phosphoric diester hydrolase activity|hydrolase activity, acting on glycosyl bonds|anchored component of membrane|negative regulation of toll-like receptor signaling pathway|innate immune response|membrane lipid catabolic process|metal ion binding|negative regulation of inflammatory response|extracellular exosome SMPX 4.91491519027222 3.52655236307142 6.30327801747302 1.7873768396234 0.83784383546524 0.598031151223064 1 0.0437896 0.0418804 0.414401 0.115779 GeneID:23676,Genbank:NM_014332.2,HGNC:HGNC:11122,MIM:300226 small muscle protein, X-linked GO:0005634,GO:0005927,GO:0006941,GO:0031430,GO:0043034 nucleus|muscle tendon junction|striated muscle contraction|M band|costamere SMS 4852.35713371084 5135.56351978384 4569.15074763783 0.889707766253108 -0.168596549156613 0.207551054206204 1 53.023 52.4241 49.3511 45.892 GeneID:6611,Genbank:NM_004595.4,HGNC:HGNC:11123,MIM:300105 spermine synthase GO:0005829,GO:0006555,GO:0006595,GO:0006597,GO:0016768,GO:0070062 cytosol|methionine metabolic process|polyamine metabolic process|spermine biosynthetic process|spermine synthase activity|extracellular exosome hsa00270,hsa00330,hsa00410,hsa00480 Cysteine and methionine metabolism|Arginine and proline metabolism|beta-Alanine metabolism|Glutathione metabolism SMTN 1300.2504443506 1309.43860335616 1291.06228534504 0.985966262210373 -0.0203898135727442 0.866649964276767 1 6.07939 6.71611 6.83951 6.56952 GeneID:6525,Genbank:NM_134269.2,HGNC:HGNC:11126,MIM:602127 smoothelin GO:0003779,GO:0005737,GO:0005856,GO:0006939,GO:0007517,GO:0008307,GO:0015629 actin binding|cytoplasm|cytoskeleton|smooth muscle contraction|muscle organ development|structural constituent of muscle|actin cytoskeleton SMTNL2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0165932 0 GeneID:342527,Genbank:NM_198501.2,HGNC:HGNC:24764 smoothelin like 2 SMU1 1794.80744240799 1856.62443292332 1732.99045189267 0.933409267465049 -0.0994183035447075 0.491123447507206 1 10.874 10.6715 10.1831 10.1316 GeneID:55234,Genbank:NM_018225.2,HGNC:HGNC:18247,MIM:617811 SMU1, DNA replication regulator and spliceosomal factor GO:0000381,GO:0005681,GO:0005737,GO:0006397,GO:0008380,GO:0016607 regulation of alternative mRNA splicing, via spliceosome|spliceosomal complex|cytoplasm|mRNA processing|RNA splicing|nuclear speck SMUG1 532.809029862647 528.220174717443 537.397885007852 1.01737478182335 0.0248512389541308 0.906113680816995 1 5.7168 6.22622 5.50481 6.62467 GeneID:23583,Genbank:NM_001351259.1,HGNC:HGNC:17148,MIM:607753 single-strand-selective monofunctional uracil-DNA glycosylase 1 hsa03410 Base excision repair SMURF1 1965.07068579475 1893.0818217669 2037.05954982261 1.07605467782756 0.105751387770447 0.452998101518004 1 11.4489 11.1941 14.1557 11.1362 GeneID:57154,Genbank:NM_001199847.1,HGNC:HGNC:16807,MIM:605568 SMAD specific E3 ubiquitin protein ligase 1 GO:0000209,GO:0004842,GO:0005543,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006611,GO:0007179,GO:0007398,GO:0016567,GO:0030154,GO:0030279,GO:0030424,GO:0030509,GO:0030512,GO:0030514,GO:0030579,GO:0032801,GO:0034394,GO:0042787,GO:0043025,GO:0043161,GO:0048185,GO:0060071,GO:0061630,GO:0061734,GO:0061736,GO:0061753,GO:0070062,GO:0070411,GO:0070412,GO:0071211,GO:0072659,GO:1903861,GO:2000060 protein polyubiquitination|ubiquitin-protein transferase activity|phospholipid binding|nucleoplasm|cytoplasm|cytosol|plasma membrane|protein export from nucleus|transforming growth factor beta receptor signaling pathway|ectoderm development|protein ubiquitination|cell differentiation|negative regulation of ossification|axon|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|ubiquitin-dependent SMAD protein catabolic process|receptor catabolic process|protein localization to cell surface|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|neuronal cell body|proteasome-mediated ubiquitin-dependent protein catabolic process|activin binding|Wnt signaling pathway, planar cell polarity pathway|ubiquitin protein ligase activity|parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization|engulfment of target by autophagosome|substrate localization to autophagosome|extracellular exosome|I-SMAD binding|R-SMAD binding|protein targeting to vacuole involved in autophagy|protein localization to plasma membrane|positive regulation of dendrite extension|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process hsa04120,hsa04144,hsa04340,hsa04350 Ubiquitin mediated proteolysis|Endocytosis|Hedgehog signaling pathway|TGF-beta signaling pathway SMURF2 599.405247358411 710.752990960479 488.057503756344 0.686676679470325 -0.542297126443442 0.00131724352057823 0.121246966813683 4.26446 4.17269 3.27222 2.64928 GeneID:64750,Genbank:XM_005257585.3,HGNC:HGNC:16809,MIM:605532 SMAD specific E3 ubiquitin protein ligase 2 GO:0000122,GO:0000151,GO:0000209,GO:0004842,GO:0005160,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006511,GO:0016579,GO:0016607,GO:0017015,GO:0030509,GO:0030512,GO:0030514,GO:0030579,GO:0042787,GO:0042802,GO:0045121,GO:0045892,GO:0046332,GO:0060071,GO:0061630,GO:0090263,GO:1901165 negative regulation of transcription from RNA polymerase II promoter|ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|transforming growth factor beta receptor binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|protein deubiquitination|nuclear speck|regulation of transforming growth factor beta receptor signaling pathway|BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|ubiquitin-dependent SMAD protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|identical protein binding|membrane raft|negative regulation of transcription, DNA-templated|SMAD binding|Wnt signaling pathway, planar cell polarity pathway|ubiquitin protein ligase activity|positive regulation of canonical Wnt signaling pathway|positive regulation of trophoblast cell migration hsa04120,hsa04144,hsa04340,hsa04350 Ubiquitin mediated proteolysis|Endocytosis|Hedgehog signaling pathway|TGF-beta signaling pathway SMYD1 1.4593380350783 0.980142803914724 1.93853326624189 1.97780696700452 0.983901626635446 0.869495943289778 1 0 0.0176608 0.0182158 0.0169704 GeneID:150572,Genbank:NM_198274.3,HGNC:HGNC:20986,MIM:606846 SET and MYND domain containing 1 GO:0003677,GO:0003714,GO:0005634,GO:0005737,GO:0006338,GO:0006351,GO:0007507,GO:0010831,GO:0018024,GO:0035914,GO:0045663,GO:0045892,GO:0046872 DNA binding|transcription corepressor activity|nucleus|cytoplasm|chromatin remodeling|transcription, DNA-templated|heart development|positive regulation of myotube differentiation|histone-lysine N-methyltransferase activity|skeletal muscle cell differentiation|positive regulation of myoblast differentiation|negative regulation of transcription, DNA-templated|metal ion binding SMYD2 1254.85192518297 1286.51110866864 1223.19274169729 0.950782883610798 -0.0728121633698373 0.604607989837728 1 24.1634 27.6244 24.794 24.3514 GeneID:56950,Genbank:NM_020197.2,HGNC:HGNC:20982,MIM:610663 SET and MYND domain containing 2 SMYD3 668.198184785406 654.589935836687 681.806433734125 1.04157793514294 0.0587707917910779 0.819387088866462 1 2.30254 2.88638 2.53328 2.9105 GeneID:64754,Genbank:NM_001167740.1,HGNC:HGNC:15513,MIM:608783 SET and MYND domain containing 3 SMYD4 677.759793360668 661.065708265755 694.45387845558 1.05050658319188 0.071085202951961 0.678274292424547 1 4.3663 4.59778 4.59622 4.90674 GeneID:114826,Genbank:NM_052928.2,HGNC:HGNC:21067 SET and MYND domain containing 4 GO:0008168,GO:0046872 methyltransferase activity|metal ion binding SMYD5 845.331767363576 817.838496615717 872.825038111436 1.06723398534461 0.0938765140146822 0.578295180991865 1 5.7917 6.98554 7.15038 6.56031 GeneID:10322,Genbank:NM_006062.2,HGNC:HGNC:16258 SMYD family member 5 GO:0008168,GO:0046872 methyltransferase activity|metal ion binding SNAI1 3.72288604940827 3.084507235799 4.36126486301754 1.41392596276008 0.499706578453293 0.831642656999839 1 0.0857015 0.074281 0.105449 0.124126 GeneID:6615,Genbank:NM_005985.3,HGNC:HGNC:11128,MIM:604238 snail family transcriptional repressor 1 hsa04520 Adherens junction SNAI2 240.430759824689 213.330879327196 267.530640322181 1.25406430220473 0.326611324291055 0.128697465100032 1 4.33813 4.50746 6.02846 4.99198 GeneID:6591,Genbank:NM_003068.4,HGNC:HGNC:11094,MIM:602150 snail family transcriptional repressor 2 hsa04390,hsa04520 Hippo signaling pathway|Adherens junction SNAI3 1.72588532371436 1.02816907859967 2.42360156882906 2.35720137793866 1.23707501465219 0.731188896846623 1 0 0.028079 0.0303479 0.0568683 GeneID:333929,Genbank:NM_178310.3,HGNC:HGNC:18411,MIM:612741 snail family transcriptional repressor 3 GO:0000978,GO:0000982,GO:0001227,GO:0005507,GO:0005634,GO:0005667,GO:0006351 RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|copper ion binding|nucleus|transcription factor complex|transcription, DNA-templated SNAP23 1281.26157788873 1393.6493642494 1168.87379152807 0.838714400847596 -0.253748467327836 0.0901778702641962 0.979717040875575 12.7439 11.476 9.91331 10.8188 GeneID:8773,Genbank:XM_017022694.1,HGNC:HGNC:11131,MIM:602534 synaptosome associated protein 23 GO:0002479,GO:0002553,GO:0005484,GO:0005654,GO:0005737,GO:0005886,GO:0005913,GO:0005925,GO:0006892,GO:0006903,GO:0015031,GO:0016082,GO:0019905,GO:0030670,GO:0031201,GO:0031629,GO:0035579,GO:0042581,GO:0042582,GO:0042629,GO:0043005,GO:0043312,GO:0061025,GO:0070062,GO:0070821,GO:0098793 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|histamine secretion by mast cell|SNAP receptor activity|nucleoplasm|cytoplasm|plasma membrane|cell-cell adherens junction|focal adhesion|post-Golgi vesicle-mediated transport|vesicle targeting|protein transport|synaptic vesicle priming|syntaxin binding|phagocytic vesicle membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|specific granule membrane|specific granule|azurophil granule|mast cell granule|neuron projection|neutrophil degranulation|membrane fusion|extracellular exosome|tertiary granule membrane|presynapse hsa04130,hsa04611 SNARE interactions in vesicular transport|Platelet activation SNAP25 65.7472754105976 67.0230952077181 64.4714556134772 0.961928950217341 -0.0559977569778437 0.925857364673037 1 0.486616 0.587878 0.753041 0.431021 GeneID:6616,Genbank:NM_001322907.1,HGNC:HGNC:11132,MIM:600322 synaptosome associated protein 25 GO:0005484,GO:0005737,GO:0005886,GO:0007626,GO:0016020,GO:0016082,GO:0017075,GO:0030054,GO:0031201,GO:0031629,GO:0043005,GO:0045162,GO:0070032,GO:0098793 SNAP receptor activity|cytoplasm|plasma membrane|locomotory behavior|membrane|synaptic vesicle priming|syntaxin-1 binding|cell junction|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|neuron projection|clustering of voltage-gated sodium channels|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|presynapse hsa04721,hsa04911 Synaptic vesicle cycle|Insulin secretion SNAP29 993.991839083921 1001.80229244419 986.181385723649 0.984407196072159 -0.0226728908705746 0.893466439986565 1 8.85789 8.49782 8.44995 8.84708 GeneID:9342,Genbank:NM_004782.3,HGNC:HGNC:11133,MIM:604202 synaptosome associated protein 29 GO:0000139,GO:0000421,GO:0005484,GO:0005654,GO:0005737,GO:0005776,GO:0005813,GO:0005829,GO:0005886,GO:0006887,GO:0006903,GO:0015031,GO:0016082,GO:0016240,GO:0019905,GO:0020018,GO:0031201,GO:0031629,GO:0035577,GO:0043312,GO:0060271,GO:0061025,GO:0097352,GO:0098793 Golgi membrane|autophagosome membrane|SNAP receptor activity|nucleoplasm|cytoplasm|autophagosome|centrosome|cytosol|plasma membrane|exocytosis|vesicle targeting|protein transport|synaptic vesicle priming|autophagosome membrane docking|syntaxin binding|ciliary pocket membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|azurophil granule membrane|neutrophil degranulation|cilium assembly|membrane fusion|autophagosome maturation|presynapse hsa04130,hsa04140 SNARE interactions in vesicular transport|Autophagy - animal SNAP47 1122.9509832587 1122.156926571 1123.74503994639 1.00141523287678 0.00204030603924083 1 1 5.2744 5.50737 5.17241 6.00872 GeneID:116841,Genbank:NM_001323933.1,HGNC:HGNC:30669 synaptosome associated protein 47 GO:0005484,GO:0005886,GO:0016082,GO:0019905,GO:0030425,GO:0030672,GO:0031201,GO:0031629,GO:0043025,GO:0048471,GO:0060291,GO:0098967 SNAP receptor activity|plasma membrane|synaptic vesicle priming|syntaxin binding|dendrite|synaptic vesicle membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|neuronal cell body|perinuclear region of cytoplasm|long-term synaptic potentiation|exocytic insertion of neurotransmitter receptor to postsynaptic membrane SNAP91 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:9892,Genbank:NM_001242794.1,HGNC:HGNC:14986,MIM:607923 synaptosome associated protein 91 GO:0005545,GO:0005886,GO:0005905,GO:0015031,GO:0019901,GO:0030136,GO:0030276,GO:0048268,GO:2000369 1-phosphatidylinositol binding|plasma membrane|clathrin-coated pit|protein transport|protein kinase binding|clathrin-coated vesicle|clathrin binding|clathrin coat assembly|regulation of clathrin-dependent endocytosis SNAPC1 608.536095608266 703.853773713499 513.218417503032 0.729154885105348 -0.455702794410347 0.00676521389779345 0.325380377738919 10.6144 10.1349 7.65621 7.39946 GeneID:6617,Genbank:NM_003082.3,HGNC:HGNC:11134,MIM:600591 small nuclear RNA activating complex polypeptide 1 GO:0005634,GO:0005654,GO:0005730,GO:0006355,GO:0019185,GO:0042795,GO:0042796,GO:0043565 nucleus|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|snRNA-activating protein complex|snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter|sequence-specific DNA binding SNAPC2 651.551545963019 622.197197032816 680.905894893222 1.09435705937021 0.130083527652752 0.444702483996473 1 17.7615 18.268 20.4557 19.7128 GeneID:6618,Genbank:NM_003083.3,HGNC:HGNC:11135,MIM:605076 small nuclear RNA activating complex polypeptide 2 GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006366,GO:0006383,GO:0009301,GO:0016604,GO:0042795 DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter|snRNA transcription|nuclear body|snRNA transcription from RNA polymerase II promoter SNAPC3 1294.16926731377 1270.1446133036 1318.19392132395 1.03782979317243 0.0535698572979881 0.705755433797126 1 8.15349 8.40527 9.07802 8.69772 GeneID:6619,Genbank:NM_001039697.1,HGNC:HGNC:11136,MIM:602348 small nuclear RNA activating complex polypeptide 3 GO:0003677,GO:0005634,GO:0005654,GO:0005730,GO:0006355,GO:0006366,GO:0006383,GO:0009301,GO:0016604,GO:0042795 DNA binding|nucleus|nucleoplasm|nucleolus|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter|snRNA transcription|nuclear body|snRNA transcription from RNA polymerase II promoter SNAPC4 505.533567199685 535.177226894216 475.889907505155 0.889219278381627 -0.169388868380225 0.324948851319928 1 3.12455 3.2226 2.87732 2.94671 GeneID:6621,Genbank:NM_003086.3,HGNC:HGNC:11137,MIM:602777 small nuclear RNA activating complex polypeptide 4 GO:0000981,GO:0001135,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0006357,GO:0006366,GO:0006383,GO:0009301,GO:0019185,GO:0030154,GO:0042795,GO:0042796,GO:0043565,GO:0044212 RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcription factor activity, RNA polymerase II transcription factor recruiting|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter|snRNA transcription|snRNA-activating protein complex|cell differentiation|snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter|sequence-specific DNA binding|transcription regulatory region DNA binding SNAPC5 529.403196425391 522.387344168639 536.419048682143 1.02686072828934 0.0382405241766648 0.865017192171446 1 6.01483 5.73479 5.76356 6.69482 GeneID:10302,Genbank:NM_006049.3,HGNC:HGNC:15484,MIM:605979 small nuclear RNA activating complex polypeptide 5 GO:0003700,GO:0005634,GO:0005654,GO:0005730,GO:0006366,GO:0006384,GO:0016604,GO:0042795 DNA binding transcription factor activity|nucleus|nucleoplasm|nucleolus|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase III promoter|nuclear body|snRNA transcription from RNA polymerase II promoter SNAPIN 1006.55530409948 1025.99910458459 987.111503614367 0.962097821726688 -0.0557445067702474 0.703909866824632 1 40.388 43.3515 38.4012 43.8979 GeneID:23557,Genbank:NM_012437.5,HGNC:HGNC:17145,MIM:607007 SNAP associated protein GO:0000139,GO:0000149,GO:0005765,GO:0006886,GO:0007042,GO:0007269,GO:0008021,GO:0008089,GO:0008090,GO:0008333,GO:0010977,GO:0016032,GO:0016079,GO:0016188,GO:0030054,GO:0030141,GO:0030672,GO:0031083,GO:0031175,GO:0031629,GO:0032418,GO:0032438,GO:0034629,GO:0043393,GO:0045202,GO:0048471,GO:0048489,GO:0048490,GO:0051604,GO:0072553,GO:0097352,GO:0099078,GO:1902774,GO:1902824,GO:1904115 Golgi membrane|SNARE binding|lysosomal membrane|intracellular protein transport|lysosomal lumen acidification|neurotransmitter secretion|synaptic vesicle|anterograde axonal transport|retrograde axonal transport|endosome to lysosome transport|negative regulation of neuron projection development|viral process|synaptic vesicle exocytosis|synaptic vesicle maturation|cell junction|secretory granule|synaptic vesicle membrane|BLOC-1 complex|neuron projection development|synaptic vesicle fusion to presynaptic active zone membrane|lysosome localization|melanosome organization|cellular protein complex localization|regulation of protein binding|synapse|perinuclear region of cytoplasm|synaptic vesicle transport|anterograde synaptic vesicle transport|protein maturation|terminal button organization|autophagosome maturation|BORC complex|late endosome to lysosome transport|positive regulation of late endosome to lysosome transport|axon cytoplasm SNCA 7.95311359463939 6.21704074628294 9.68918644299584 1.55848848968681 0.640147499889117 0.562586170478081 1 0.0692723 0.0222913 0.0333754 0.13492 GeneID:6622,Genbank:NM_001146055.1,HGNC:HGNC:11138,MIM:163890 synuclein alpha hsa05010,hsa05012 Alzheimer disease|Parkinson disease SNCAIP 20.9268745081097 17.6229531602492 24.2307958559702 1.37495660549254 0.459386086980108 0.461304476346041 1 0.0647506 0.0390754 0.0793833 0.0740325 GeneID:9627,Genbank:XM_006714734.2,HGNC:HGNC:11139,MIM:603779 synuclein alpha interacting protein GO:0005654,GO:0005737,GO:0005829,GO:0008021,GO:0008219,GO:0031625,GO:0036464,GO:0042417,GO:0042734,GO:0042802,GO:0043025,GO:0044267,GO:0046928,GO:0090083 nucleoplasm|cytoplasm|cytosol|synaptic vesicle|cell death|ubiquitin protein ligase binding|cytoplasmic ribonucleoprotein granule|dopamine metabolic process|presynaptic membrane|identical protein binding|neuronal cell body|cellular protein metabolic process|regulation of neurotransmitter secretion|regulation of inclusion body assembly hsa05012 Parkinson disease SNCB 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:6620,Genbank:NM_001318036.1,HGNC:HGNC:11140,MIM:602569 synuclein beta GO:0004859,GO:0005509,GO:0005739,GO:0005829,GO:0007268,GO:0010038,GO:0016234,GO:0042417,GO:0043524,GO:0045202,GO:0046914,GO:0050808,GO:1903136 phospholipase inhibitor activity|calcium ion binding|mitochondrion|cytosol|chemical synaptic transmission|response to metal ion|inclusion body|dopamine metabolic process|negative regulation of neuron apoptotic process|synapse|transition metal ion binding|synapse organization|cuprous ion binding SNCG 5.15007707996561 6.90902590208801 3.3911282578432 0.490825813349224 -1.02671697014975 0.61028443312461 1 0.042594 0.260846 0 0.110963 GeneID:6623,Genbank:NM_001330120.1,HGNC:HGNC:11141,MIM:602998 synuclein gamma SND1 8121.94093126623 7572.48625955105 8671.39560298141 1.14511869758025 0.195497149007711 0.139766174511974 1 32.8979 35.5855 40.076 39.2122 GeneID:27044,Genbank:NM_014390.3,HGNC:HGNC:30646,MIM:602181 staphylococcal nuclease and tudor domain containing 1 GO:0001649,GO:0003712,GO:0003723,GO:0004518,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006351,GO:0006355,GO:0006401,GO:0016020,GO:0016032,GO:0016442,GO:0031047,GO:0042470,GO:0045296,GO:0070062,GO:0097433 osteoblast differentiation|transcription cofactor activity|RNA binding|nuclease activity|nucleus|cytoplasm|mitochondrion|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA catabolic process|membrane|viral process|RISC complex|gene silencing by RNA|melanosome|cadherin binding|extracellular exosome|dense body hsa05203 Viral carcinogenesis SNED1 34.5214415427521 31.7291626125348 37.3137204729694 1.17600709885197 0.233896768888239 0.654325330377893 1 0.0658865 0.0546424 0.103647 0.107816 GeneID:25992,Genbank:XM_011510933.2,HGNC:HGNC:24696,MIM:616634 sushi, nidogen and EGF like domains 1 GO:0005509,GO:0007160,GO:0070062 calcium ion binding|cell-matrix adhesion|extracellular exosome SNF8 2627.06038448073 2529.62535962543 2724.49540933603 1.07703514236569 0.107065324059983 0.439992536307645 1 38.9355 40.8003 45.9695 45.7795 GeneID:11267,Genbank:NM_001317193.1,HGNC:HGNC:17028,MIM:610904 SNF8, ESCRT-II complex subunit GO:0000814,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0006357,GO:0008022,GO:0008134,GO:0010008,GO:0010628,GO:0010797,GO:0016020,GO:0016197,GO:0016236,GO:0016247,GO:0031902,GO:0032456,GO:0036258,GO:0042176,GO:0042803,GO:0043328,GO:0045022,GO:0045732,GO:0047485,GO:0048471,GO:0055037,GO:0061635,GO:0070062,GO:0071985,GO:1903543,GO:1903772 ESCRT II complex|nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|protein C-terminus binding|transcription factor binding|endosome membrane|positive regulation of gene expression|regulation of multivesicular body size involved in endosome transport|membrane|endosomal transport|macroautophagy|channel regulator activity|late endosome membrane|endocytic recycling|multivesicular body assembly|regulation of protein catabolic process|protein homodimerization activity|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|early endosome to late endosome transport|positive regulation of protein catabolic process|protein N-terminus binding|perinuclear region of cytoplasm|recycling endosome|regulation of protein complex stability|extracellular exosome|multivesicular body sorting pathway|positive regulation of exosomal secretion|regulation of viral budding via host ESCRT complex hsa04144 Endocytosis SNIP1 563.463987685877 594.811033452996 532.116941918757 0.894598304321479 -0.160688071118193 0.339785249969278 1 5.45695 5.79661 5.19603 5.06465 GeneID:79753,Genbank:NM_024700.3,HGNC:HGNC:30587,MIM:608241 Smad nuclear interacting protein 1 GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0007249,GO:0035196,GO:1903955 RNA binding|mRNA binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|I-kappaB kinase/NF-kappaB signaling|production of miRNAs involved in gene silencing by miRNA|positive regulation of protein targeting to mitochondrion SNN 1282.24922108055 1293.82294507757 1270.67549708353 0.98210926148581 -0.0260445589064151 0.850851526878 1 15.5871 16.3457 15.9499 15.8135 GeneID:8303,Genbank:NM_003498.5,HGNC:HGNC:11149,MIM:603032 stannin SNORC 18.7597152573601 14.7403596782979 22.7790708364223 1.54535379960638 0.627937172436282 0.361492903603873 1 0.0737541 0.148607 0.181558 0.137768 GeneID:389084,Genbank:XM_017004082.2,HGNC:HGNC:33763 secondary ossification center associated regulator of chondrocyte maturation GO:0005578,GO:0005737,GO:0016021,GO:0051216,GO:0071944 proteinaceous extracellular matrix|cytoplasm|integral component of membrane|cartilage development|cell periphery SNPH 113.534994698572 106.891366554788 120.178622842356 1.12430616911196 0.169034961280695 0.569148453437439 1 0.731467 0.773671 0.867454 0.959119 GeneID:9751,Genbank:NM_001318234.1,HGNC:HGNC:15931,MIM:604942 syntaphilin GO:0005737,GO:0005881,GO:0007269,GO:0007420,GO:0016021,GO:0016081,GO:0017075,GO:0030054,GO:0030182,GO:0031966,GO:0042734,GO:0043005,GO:0043025 cytoplasm|cytoplasmic microtubule|neurotransmitter secretion|brain development|integral component of membrane|synaptic vesicle docking|syntaxin-1 binding|cell junction|neuron differentiation|mitochondrial membrane|presynaptic membrane|neuron projection|neuronal cell body SNRK 355.792617148089 367.988477589311 343.596756706867 0.933716074366693 -0.0989441749047293 0.61864117573727 1 2.85261 2.6182 2.57403 2.52866 GeneID:54861,Genbank:XM_005265245.3,HGNC:HGNC:30598,MIM:612760 SNF related kinase GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0030099,GO:0035556 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|myeloid cell differentiation|intracellular signal transduction SNRNP200 8801.98000424031 8894.18137160698 8709.77863687364 0.979267036838038 -0.0302257721474486 0.812580396815616 1 37.4645 37.9524 38.5097 35.9025 GeneID:23020,Genbank:NM_014014.4,HGNC:HGNC:30859,MIM:601664 small nuclear ribonucleoprotein U5 subunit 200 GO:0000354,GO:0000398,GO:0001649,GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0008026,GO:0016020,GO:0042802,GO:0046540,GO:0071013 cis assembly of pre-catalytic spliceosome|mRNA splicing, via spliceosome|osteoblast differentiation|RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|ATP-dependent helicase activity|membrane|identical protein binding|U4/U6 x U5 tri-snRNP complex|catalytic step 2 spliceosome hsa03040 Spliceosome SNRNP25 729.073888447245 761.299005947843 696.848770946647 0.915341758628789 -0.127617595837712 0.518657700744696 1 21.9362 26.6566 21.4164 23.9213 GeneID:79622,Genbank:NM_024571.3,HGNC:HGNC:14161 small nuclear ribonucleoprotein U11/U12 subunit 25 GO:0000398,GO:0005634,GO:0005654,GO:0005689,GO:0005829,GO:0008380,GO:0045171 mRNA splicing, via spliceosome|nucleus|nucleoplasm|U12-type spliceosomal complex|cytosol|RNA splicing|intercellular bridge SNRNP27 848.466212873824 940.4385229959 756.493902751748 0.804405481329954 -0.31400518248751 0.0470753124469189 0.796154386641873 26.0051 25.4861 21.3383 20.8417 GeneID:11017,Genbank:NM_006857.2,HGNC:HGNC:30240 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 GO:0006397,GO:0008380,GO:0071011 mRNA processing|RNA splicing|precatalytic spliceosome hsa03040 Spliceosome SNRNP35 483.360261446296 449.675497236173 517.045025656419 1.14981809957251 0.201405645864037 0.305871237248391 1 6.05972 6.46885 6.48633 7.95176 GeneID:11066,Genbank:XM_017018724.2,HGNC:HGNC:30852 small nuclear ribonucleoprotein U11/U12 subunit 35 GO:0000243,GO:0000398,GO:0003729,GO:0005634,GO:0005654,GO:0005689,GO:0005730,GO:0008380,GO:0017069,GO:0071011 commitment complex|mRNA splicing, via spliceosome|mRNA binding|nucleus|nucleoplasm|U12-type spliceosomal complex|nucleolus|RNA splicing|snRNA binding|precatalytic spliceosome SNRNP40 1617.86709126105 1686.51588951774 1549.21829300435 0.918590985494568 -0.122505469009864 0.423464880496192 1 37.4718 37.4846 32.2274 36.8852 GeneID:9410,Genbank:NM_004814.2,HGNC:HGNC:30857,MIM:607797 small nuclear ribonucleoprotein U5 subunit 40 GO:0000375,GO:0000398,GO:0003723,GO:0005654,GO:0005682,GO:0005732,GO:0005829,GO:0006396,GO:0008380,GO:0016607,GO:0071011,GO:0071013 RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|nucleoplasm|U5 snRNP|small nucleolar ribonucleoprotein complex|cytosol|RNA processing|RNA splicing|nuclear speck|precatalytic spliceosome|catalytic step 2 spliceosome hsa03040 Spliceosome SNRNP48 368.277758077538 419.579227962926 316.97628819215 0.755462299053943 -0.404568334633019 0.0341421182549373 0.7290935546281 4.58617 4.16613 3.70586 2.94067 GeneID:154007,Genbank:NM_152551.3,HGNC:HGNC:21368 small nuclear ribonucleoprotein U11/U12 subunit 48 GO:0000398,GO:0005654,GO:0005689,GO:0005829,GO:0008380,GO:0046872 mRNA splicing, via spliceosome|nucleoplasm|U12-type spliceosomal complex|cytosol|RNA splicing|metal ion binding SNRNP70 5570.1906534015 5820.81150788405 5319.56979891894 0.913888001993159 -0.129910722677866 0.314589537803425 1 77.9547 81.8435 72.8719 78.4118 GeneID:6625,Genbank:NM_003089.5,HGNC:HGNC:11150,MIM:180740 small nuclear ribonucleoprotein U1 subunit 70 GO:0000243,GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0005681,GO:0005685,GO:0005737,GO:0006397,GO:0008380,GO:0016607,GO:0030619,GO:0043462,GO:0043484,GO:0048026,GO:0061084,GO:0071004,GO:0071011,GO:0071300,GO:0071356,GO:0071560,GO:1904715,GO:1990446 commitment complex|mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nucleoplasm|spliceosomal complex|U1 snRNP|cytoplasm|mRNA processing|RNA splicing|nuclear speck|U1 snRNA binding|regulation of ATPase activity|regulation of RNA splicing|positive regulation of mRNA splicing, via spliceosome|negative regulation of protein refolding|U2-type prespliceosome|precatalytic spliceosome|cellular response to retinoic acid|cellular response to tumor necrosis factor|cellular response to transforming growth factor beta stimulus|negative regulation of chaperone-mediated autophagy|U1 snRNP binding hsa03040 Spliceosome SNRPA 2141.89399174024 2200.42895802991 2083.35902545058 0.94679676789741 -0.0788733137687182 0.5646591168555 1 57.7552 59.141 55.4246 56.0129 GeneID:6626,Genbank:NM_004596.4,HGNC:HGNC:11151,MIM:182285 small nuclear ribonucleoprotein polypeptide A GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0005685,GO:0030619,GO:0035614,GO:0042802,GO:1900363,GO:1990446 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|U1 snRNP|U1 snRNA binding|snRNA stem-loop binding|identical protein binding|regulation of mRNA polyadenylation|U1 snRNP binding hsa03040 Spliceosome SNRPA1 1234.04603856964 1311.25277613822 1156.83930100105 0.882239734437825 -0.18075735669087 0.224634227722657 1 42.0518 40.6269 37.8349 34.1331 GeneID:6627,Genbank:NM_003090.3,HGNC:HGNC:11152,MIM:603521 small nuclear ribonucleoprotein polypeptide A' GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0005686,GO:0008380,GO:0016604,GO:0016607,GO:0030532,GO:0030620,GO:0035722,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|U2 snRNP|RNA splicing|nuclear body|nuclear speck|small nuclear ribonucleoprotein complex|U2 snRNA binding|interleukin-12-mediated signaling pathway|catalytic step 2 spliceosome hsa03040 Spliceosome SNRPB 4963.89087113671 5277.73632062958 4650.04542164385 0.88106815860955 -0.182674465884177 0.302258780025809 1 167.251 176.785 139.337 163.703 GeneID:6628,Genbank:NM_198216.1,HGNC:HGNC:11153,MIM:182282 small nuclear ribonucleoprotein polypeptides B and B1 GO:0000387,GO:0003723,GO:0005681,GO:0005683,GO:0005685,GO:0005687,GO:0005829,GO:0034709,GO:0034719 spliceosomal snRNP assembly|RNA binding|spliceosomal complex|U7 snRNP|U1 snRNP|U4 snRNP|cytosol|methylosome|SMN-Sm protein complex hsa03040,hsa05322 Spliceosome|Systemic lupus erythematosus SNRPB2 965.494066947653 1050.48204037139 880.506093523918 0.838192429460882 -0.254646603755941 0.098133947581428 1 23.7458 24.801 19.0834 21.4561 GeneID:6629,Genbank:NM_003092.4,HGNC:HGNC:11155,MIM:603520 small nuclear ribonucleoprotein polypeptide B2 GO:0000398,GO:0001650,GO:0005654,GO:0005681,GO:0005685,GO:0005686,GO:0016607,GO:0030619,GO:0035614,GO:0070990,GO:0071013 mRNA splicing, via spliceosome|fibrillar center|nucleoplasm|spliceosomal complex|U1 snRNP|U2 snRNP|nuclear speck|U1 snRNA binding|snRNA stem-loop binding|snRNP binding|catalytic step 2 spliceosome hsa03040 Spliceosome SNRPC 3871.65411783491 4095.28876896101 3648.01946670881 0.89078442877041 -0.166851755365221 0.211466409807892 1 143.492 145.774 122.083 136.943 GeneID:6631,Genbank:NM_003093.2,HGNC:HGNC:11157,MIM:603522 small nuclear ribonucleoprotein polypeptide C GO:0000243,GO:0000387,GO:0000395,GO:0003727,GO:0005685,GO:0008270,GO:0015030,GO:0030627,GO:0042803,GO:0071010 commitment complex|spliceosomal snRNP assembly|mRNA 5'-splice site recognition|single-stranded RNA binding|U1 snRNP|zinc ion binding|Cajal body|pre-mRNA 5'-splice site binding|protein homodimerization activity|prespliceosome hsa03040 Spliceosome SNRPD1 1482.35995632035 1643.19750104675 1321.52241159395 0.804238328473666 -0.314305001000763 0.0309667311880194 0.695600514316014 41.1115 41.9798 32.2357 33.9236 GeneID:6632,Genbank:NM_006938.3,HGNC:HGNC:11158,MIM:601063 small nuclear ribonucleoprotein D1 polypeptide GO:0000243,GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005682,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005829,GO:0008380,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0051170,GO:0071010,GO:0071011,GO:0071013,GO:0097526,GO:1990446 commitment complex|spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|U5 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|cytosol|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|nuclear import|prespliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|spliceosomal tri-snRNP complex|U1 snRNP binding hsa03040,hsa05322 Spliceosome|Systemic lupus erythematosus SNRPD2 5632.52767531315 5798.1478298836 5466.90752074271 0.942871358430415 -0.0848671460596639 0.708532037214394 1 100.398 116.479 96.461 118.456 GeneID:6633,Genbank:NM_004597.6,HGNC:HGNC:11159,MIM:601061 small nuclear ribonucleoprotein D2 polypeptide GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0005682,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005829,GO:0008380,GO:0030532,GO:0034709,GO:0034715,GO:0034719,GO:0046540,GO:0051170,GO:0070062,GO:0071011,GO:0071013 spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|U5 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|cytosol|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|U4/U6 x U5 tri-snRNP complex|nuclear import|extracellular exosome|precatalytic spliceosome|catalytic step 2 spliceosome hsa03040 Spliceosome SNRPD3 2657.41262867576 2786.09908863253 2528.72616871899 0.907622481567996 -0.13983575026124 0.315441928288015 1 28.7829 28.1216 25.8168 25.8423 GeneID:6634,Genbank:NM_004175.4,HGNC:HGNC:11160,MIM:601062 small nuclear ribonucleoprotein D3 polypeptide GO:0000243,GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0005682,GO:0005683,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005829,GO:0006369,GO:0006479,GO:0008334,GO:0008380,GO:0016604,GO:0019899,GO:0030532,GO:0030620,GO:0034709,GO:0034715,GO:0034719,GO:0051170,GO:0070034,GO:0070062,GO:0071010,GO:0071011,GO:0071013,GO:0071208,GO:0071209,GO:0097526,GO:1990446 commitment complex|spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|U5 snRNP|U7 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|cytosol|termination of RNA polymerase II transcription|protein methylation|histone mRNA metabolic process|RNA splicing|nuclear body|enzyme binding|small nuclear ribonucleoprotein complex|U2 snRNA binding|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|nuclear import|telomerase RNA binding|extracellular exosome|prespliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|histone pre-mRNA DCP binding|U7 snRNA binding|spliceosomal tri-snRNP complex|U1 snRNP binding hsa03040,hsa05322 Spliceosome|Systemic lupus erythematosus SNRPE 1164.84409117876 1319.34385859807 1010.34432375945 0.76579302444553 -0.384973576046476 0.0161059611943721 0.529251203244782 20.1753 20.137 14.1835 18.8557 GeneID:6635,Genbank:NM_001304464.1,HGNC:HGNC:11161,MIM:128260 small nuclear ribonucleoprotein polypeptide E GO:0000387,GO:0003723,GO:0005634,GO:0005682,GO:0005683,GO:0005685,GO:0005686,GO:0005687,GO:0005829,GO:0034709,GO:0034715,GO:0034719,GO:0042633,GO:0046540,GO:0071011 spliceosomal snRNP assembly|RNA binding|nucleus|U5 snRNP|U7 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|cytosol|methylosome|pICln-Sm protein complex|SMN-Sm protein complex|hair cycle|U4/U6 x U5 tri-snRNP complex|precatalytic spliceosome hsa03040 Spliceosome SNRPF 1132.79580180219 1252.29337142674 1013.29823217765 0.809154033150549 -0.305513730044767 0.0385827293581021 0.7508396031584 66.9572 80.2088 56.5444 62.0723 GeneID:6636,Genbank:NM_003095.2,HGNC:HGNC:11162,MIM:603541 small nuclear ribonucleoprotein polypeptide F GO:0000387,GO:0003723,GO:0005681,GO:0005685,GO:0005687,GO:0005732,GO:0005829,GO:0034709,GO:0034715,GO:0034719 spliceosomal snRNP assembly|RNA binding|spliceosomal complex|U1 snRNP|U4 snRNP|small nucleolar ribonucleoprotein complex|cytosol|methylosome|pICln-Sm protein complex|SMN-Sm protein complex hsa03040 Spliceosome SNRPG 1580.76518258765 1731.54665756974 1429.98370760557 0.825841857251817 -0.276062552470086 0.197142083344181 1 2.92527 3.22928 2.52416 2.7211 GeneID:6637,Genbank:NM_001317171.1,HGNC:HGNC:11163,MIM:603542 small nuclear ribonucleoprotein polypeptide G GO:0000245,GO:0000387,GO:0000398,GO:0003723,GO:0005654,GO:0005681,GO:0005682,GO:0005683,GO:0005685,GO:0005686,GO:0005687,GO:0005689,GO:0005829,GO:0006369,GO:0008334,GO:0008380,GO:0030532,GO:0034709,GO:0034719,GO:0043186,GO:0051170,GO:0071004,GO:0071011,GO:0071013,GO:0097526 spliceosomal complex assembly|spliceosomal snRNP assembly|mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|U5 snRNP|U7 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|U12-type spliceosomal complex|cytosol|termination of RNA polymerase II transcription|histone mRNA metabolic process|RNA splicing|small nuclear ribonucleoprotein complex|methylosome|SMN-Sm protein complex|P granule|nuclear import|U2-type prespliceosome|precatalytic spliceosome|catalytic step 2 spliceosome|spliceosomal tri-snRNP complex hsa03040 Spliceosome SNRPN 5.98297667637833 8.57134520669987 3.39460814605679 0.396041468893747 -1.33627659429193 0.28284761907771 1 7.98828 7.57978 8.14135 9.18937 GeneID:6638,Genbank:NM_022807.4,HGNC:HGNC:11164,MIM:182279 small nuclear ribonucleoprotein polypeptide N GO:0000398,GO:0003723,GO:0005654,GO:0005682,GO:0005685,GO:0005686,GO:0005687,GO:0005737,GO:0046540,GO:0071004,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|U5 snRNP|U1 snRNP|U2 snRNP|U4 snRNP|cytoplasm|U4/U6 x U5 tri-snRNP complex|U2-type prespliceosome|catalytic step 2 spliceosome SNTA1 393.01282141719 353.758823624041 432.266819210339 1.22192519406875 0.289155966458231 0.252687982634944 1 4.70332 6.17088 6.72797 6.66852 GeneID:6640,Genbank:NM_003098.2,HGNC:HGNC:11167,MIM:601017 syntrophin alpha 1 GO:0002027,GO:0003779,GO:0005198,GO:0005516,GO:0005622,GO:0005737,GO:0005856,GO:0006936,GO:0016013,GO:0030054,GO:0030165,GO:0031594,GO:0042383,GO:0043234,GO:0044325,GO:0050998,GO:0051117,GO:0060307,GO:0065009,GO:0086005,GO:1902083,GO:1902305 regulation of heart rate|actin binding|structural molecule activity|calmodulin binding|intracellular|cytoplasm|cytoskeleton|muscle contraction|syntrophin complex|cell junction|PDZ domain binding|neuromuscular junction|sarcolemma|protein complex|ion channel binding|nitric-oxide synthase binding|ATPase binding|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of molecular function|ventricular cardiac muscle cell action potential|negative regulation of peptidyl-cysteine S-nitrosylation|regulation of sodium ion transmembrane transport SNTB1 112.367979534433 109.38974983926 115.346209229606 1.05445171416059 0.0764930322240395 0.816347470039227 1 0.814926 0.95773 1.04549 0.846308 GeneID:6641,Genbank:NM_021021.3,HGNC:HGNC:11168,MIM:600026 syntrophin beta 1 GO:0003779,GO:0005198,GO:0005516,GO:0005737,GO:0005856,GO:0005925,GO:0006936,GO:0016010,GO:0030165,GO:0042383,GO:0043234,GO:0045202 actin binding|structural molecule activity|calmodulin binding|cytoplasm|cytoskeleton|focal adhesion|muscle contraction|dystrophin-associated glycoprotein complex|PDZ domain binding|sarcolemma|protein complex|synapse SNTB2 854.37040937398 889.127138616141 819.613680131818 0.921818314316088 -0.117445664042347 0.53374113688321 1 4.07663 4.3594 4.57123 3.25631 GeneID:6645,Genbank:NM_006750.3,HGNC:HGNC:11169,MIM:600027 syntrophin beta 2 GO:0003723,GO:0003779,GO:0005198,GO:0005516,GO:0005737,GO:0005874,GO:0005925,GO:0016010,GO:0016020,GO:0030658,GO:0043234,GO:0045202,GO:0070062 RNA binding|actin binding|structural molecule activity|calmodulin binding|cytoplasm|microtubule|focal adhesion|dystrophin-associated glycoprotein complex|membrane|transport vesicle membrane|protein complex|synapse|extracellular exosome SNTG1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:54212,Genbank:NM_001287813.2,HGNC:HGNC:13740,MIM:608714 syntrophin gamma 1 GO:0003779,GO:0005198,GO:0005634,GO:0005737,GO:0005856,GO:0007154,GO:0008022,GO:0016013,GO:0032587 actin binding|structural molecule activity|nucleus|cytoplasm|cytoskeleton|cell communication|protein C-terminus binding|syntrophin complex|ruffle membrane SNTG2 1.72294878800257 0.538097676642304 2.90779989936283 5.40385142992498 2.43398801066343 0.443399387359121 1 0.0034934 0 0.00333989 0 GeneID:54221,Genbank:NM_018968.3,HGNC:HGNC:13741,MIM:608715 syntrophin gamma 2 GO:0003779,GO:0005198,GO:0005737,GO:0005856,GO:0007417,GO:0016013,GO:0030165,GO:0042383,GO:0097109 actin binding|structural molecule activity|cytoplasm|cytoskeleton|central nervous system development|syntrophin complex|PDZ domain binding|sarcolemma|neuroligin family protein binding SNU13 2009.79339167073 2106.87436353159 1912.71241980988 0.907843606110308 -0.13948430851925 0.31942320415925 1 34.0427 34.7792 30.2007 32.6586 GeneID:4809,Genbank:NM_001003796.1,HGNC:HGNC:7819,MIM:601304 small nuclear ribonucleoprotein 13 GO:0000398,GO:0000470,GO:0000492,GO:0001651,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0007338,GO:0030490,GO:0030621,GO:0030622,GO:0031428,GO:0032040,GO:0034511,GO:0034512,GO:0043234,GO:0046540,GO:0051117,GO:0071011 mRNA splicing, via spliceosome|maturation of LSU-rRNA|box C/D snoRNP assembly|dense fibrillar component|RNA binding|nucleus|nucleoplasm|nucleolus|rRNA processing|single fertilization|maturation of SSU-rRNA|U4 snRNA binding|U4atac snRNA binding|box C/D snoRNP complex|small-subunit processome|U3 snoRNA binding|box C/D snoRNA binding|protein complex|U4/U6 x U5 tri-snRNP complex|ATPase binding|precatalytic spliceosome hsa03008,hsa03040 Ribosome biogenesis in eukaryotes|Spliceosome SNUPN 625.52287196337 593.907325888236 657.138418038504 1.10646626063368 0.145959459852349 0.37748319422613 1 9.15802 8.84323 9.91303 9.96854 GeneID:10073,Genbank:NM_001042588.1,HGNC:HGNC:14245,MIM:607902 snurportin 1 GO:0000339,GO:0000387,GO:0005643,GO:0005829,GO:0006606,GO:0008565,GO:0051170,GO:0061015,GO:0070062 RNA cap binding|spliceosomal snRNP assembly|nuclear pore|cytosol|protein import into nucleus|protein transporter activity|nuclear import|snRNA import into nucleus|extracellular exosome hsa03013 RNA transport SNW1 1123.43177214879 1164.16574596782 1082.69779832975 0.930020318910562 -0.104665858590049 0.504716112640714 1 14.0144 12.5747 13.1366 11.3221 GeneID:22938,Genbank:XM_005267413.4,HGNC:HGNC:16696,MIM:603055 SNW domain containing 1 GO:0000122,GO:0000350,GO:0000398,GO:0003713,GO:0003714,GO:0003723,GO:0005112,GO:0005634,GO:0005654,GO:0005681,GO:0006357,GO:0006367,GO:0007219,GO:0007221,GO:0016032,GO:0016363,GO:0016604,GO:0016607,GO:0019899,GO:0030511,GO:0035257,GO:0042771,GO:0042809,GO:0042974,GO:0043923,GO:0045747,GO:0045892,GO:0045944,GO:0046332,GO:0048026,GO:0048384,GO:0048385,GO:0050681,GO:0050769,GO:0051571,GO:0070562,GO:0070564,GO:0071013,GO:0071014,GO:0071300 negative regulation of transcription from RNA polymerase II promoter|generation of catalytic spliceosome for second transesterification step|mRNA splicing, via spliceosome|transcription coactivator activity|transcription corepressor activity|RNA binding|Notch binding|nucleus|nucleoplasm|spliceosomal complex|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|Notch signaling pathway|positive regulation of transcription of Notch receptor target|viral process|nuclear matrix|nuclear body|nuclear speck|enzyme binding|positive regulation of transforming growth factor beta receptor signaling pathway|nuclear hormone receptor binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|vitamin D receptor binding|retinoic acid receptor binding|positive regulation by host of viral transcription|positive regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|SMAD binding|positive regulation of mRNA splicing, via spliceosome|retinoic acid receptor signaling pathway|regulation of retinoic acid receptor signaling pathway|androgen receptor binding|positive regulation of neurogenesis|positive regulation of histone H3-K4 methylation|regulation of vitamin D receptor signaling pathway|positive regulation of vitamin D receptor signaling pathway|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex|cellular response to retinoic acid hsa03040,hsa04330,hsa05169,hsa05203 Spliceosome|Notch signaling pathway|Epstein-Barr virus infection|Viral carcinogenesis SNX1 3084.03819961988 3107.28287700906 3060.7935222307 0.985038583026238 -0.0217478602163613 0.878154128661921 1 14.1538 14.252 13.835 14.4475 GeneID:6642,Genbank:XM_005254611.3,HGNC:HGNC:11172,MIM:601272 sorting nexin 1 GO:0005154,GO:0005158,GO:0005737,GO:0005764,GO:0005768,GO:0005794,GO:0005829,GO:0006886,GO:0010008,GO:0016020,GO:0016050,GO:0019898,GO:0030027,GO:0030904,GO:0030905,GO:0031623,GO:0031901,GO:0031982,GO:0034498,GO:0035091,GO:0042147,GO:0042802,GO:0042803,GO:0043231,GO:0043234,GO:0045296,GO:0045732,GO:0046982,GO:0072673,GO:1990459,GO:1990460 epidermal growth factor receptor binding|insulin receptor binding|cytoplasm|lysosome|endosome|Golgi apparatus|cytosol|intracellular protein transport|endosome membrane|membrane|vesicle organization|extrinsic component of membrane|lamellipodium|retromer complex|retromer, tubulation complex|receptor internalization|early endosome membrane|vesicle|early endosome to Golgi transport|phosphatidylinositol binding|retrograde transport, endosome to Golgi|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|protein complex|cadherin binding|positive regulation of protein catabolic process|protein heterodimerization activity|lamellipodium morphogenesis|transferrin receptor binding|leptin receptor binding hsa04144 Endocytosis SNX10 127.630998333385 120.526104914478 134.735891752292 1.11789800100067 0.160788560127815 0.529286038227462 1 1.40534 0.965769 1.48381 1.17943 GeneID:29887,Genbank:NM_001199835.1,HGNC:HGNC:14974,MIM:614780 sorting nexin 10 GO:0005545,GO:0005634,GO:0005783,GO:0005815,GO:0006897,GO:0007032,GO:0015031,GO:0030316,GO:0031313,GO:0051117,GO:0060271,GO:0061512,GO:0071539,GO:1990830 1-phosphatidylinositol binding|nucleus|endoplasmic reticulum|microtubule organizing center|endocytosis|endosome organization|protein transport|osteoclast differentiation|extrinsic component of endosome membrane|ATPase binding|cilium assembly|protein localization to cilium|protein localization to centrosome|cellular response to leukemia inhibitory factor SNX11 812.011656636495 788.530265047645 835.493048225345 1.05955736293123 0.0834616952855372 0.615804692839123 1 7.91132 9.02885 9.41933 8.8853 GeneID:29916,Genbank:NM_001330320.1,HGNC:HGNC:14975,MIM:614906 sorting nexin 11 GO:0005768,GO:0006886,GO:0006897,GO:0016050,GO:0019898,GO:1901981 endosome|intracellular protein transport|endocytosis|vesicle organization|extrinsic component of membrane|phosphatidylinositol phosphate binding SNX12 3248.27671692328 3220.99905957339 3275.55437427318 1.01693738920465 0.024230858089639 0.872567811076783 1 60.9728 64.6308 66.1252 64.6895 GeneID:29934,Genbank:NM_001256185.1,HGNC:HGNC:14976,MIM:300883 sorting nexin 12 GO:0005769,GO:0010629,GO:0010955,GO:0015031,GO:0016050,GO:0019898,GO:0019899,GO:0030100,GO:0035091,GO:0042177,GO:0051224,GO:0070062,GO:2000642 early endosome|negative regulation of gene expression|negative regulation of protein processing|protein transport|vesicle organization|extrinsic component of membrane|enzyme binding|regulation of endocytosis|phosphatidylinositol binding|negative regulation of protein catabolic process|negative regulation of protein transport|extracellular exosome|negative regulation of early endosome to late endosome transport hsa04144 Endocytosis SNX13 444.098909846625 437.922575243449 450.275244449802 1.0282074273049 0.0401313386142596 0.853015956940962 1 1.26406 1.07357 1.38506 1.01102 GeneID:23161,Genbank:NM_001350863.1,HGNC:HGNC:21335,MIM:606589 sorting nexin 13 GO:0005769,GO:0006886,GO:0009968,GO:0031901,GO:0032266,GO:0035091,GO:0043547 early endosome|intracellular protein transport|negative regulation of signal transduction|early endosome membrane|phosphatidylinositol-3-phosphate binding|phosphatidylinositol binding|positive regulation of GTPase activity SNX14 1203.29789831532 1244.34331678838 1162.25247984226 0.9340287878445 -0.0984610787420837 0.606696900124491 1 8.80786 8.29519 9.12868 7.11678 GeneID:57231,Genbank:NM_001350543.1,HGNC:HGNC:14977,MIM:616105 sorting nexin 14 GO:0005764,GO:0005765,GO:0005770,GO:0015031,GO:0016021,GO:0030425,GO:0031902,GO:0080025,GO:0097352 lysosome|lysosomal membrane|late endosome|protein transport|integral component of membrane|dendrite|late endosome membrane|phosphatidylinositol-3,5-bisphosphate binding|autophagosome maturation SNX15 670.078414520189 650.591912381019 689.564916659359 1.05990391755057 0.0839334874713932 0.647924336646221 1 12.1836 12.1627 12.3541 14.3492 GeneID:29907,Genbank:NM_013306.4,HGNC:HGNC:14978,MIM:605964 sorting nexin 15 GO:0005730,GO:0005737,GO:0005829,GO:0006886,GO:0007165,GO:0016020,GO:0030659,GO:0035091 nucleolus|cytoplasm|cytosol|intracellular protein transport|signal transduction|membrane|cytoplasmic vesicle membrane|phosphatidylinositol binding SNX16 70.9201594416418 74.9504815332978 66.8898373499858 0.892453737208734 -0.164150709868217 0.679037339786184 1 0.83035 0.641758 0.885172 0.512396 GeneID:64089,Genbank:XM_005251282.4,HGNC:HGNC:14980,MIM:614903 sorting nexin 16 GO:0005764,GO:0005769,GO:0005770,GO:0005829,GO:0006622,GO:0008333,GO:0031313,GO:0031901,GO:0031902,GO:0035091,GO:0042802,GO:0043231,GO:0045022 lysosome|early endosome|late endosome|cytosol|protein targeting to lysosome|endosome to lysosome transport|extrinsic component of endosome membrane|early endosome membrane|late endosome membrane|phosphatidylinositol binding|identical protein binding|intracellular membrane-bounded organelle|early endosome to late endosome transport SNX17 3257.36558606147 3170.41889496987 3344.31227715308 1.05484870862305 0.0770360956424415 0.593894130452753 1 48.0273 53.0762 53.0293 53.9669 GeneID:9784,Genbank:NM_014748.3,HGNC:HGNC:14979,MIM:605963 sorting nexin 17 GO:0003279,GO:0005102,GO:0005768,GO:0005769,GO:0005794,GO:0005829,GO:0006707,GO:0006886,GO:0006898,GO:0007165,GO:0008022,GO:0010008,GO:0016020,GO:0016197,GO:0030100,GO:0030659,GO:0031410,GO:0035091,GO:0035904,GO:0043231,GO:0043234,GO:0050750,GO:0060976,GO:1990126 cardiac septum development|receptor binding|endosome|early endosome|Golgi apparatus|cytosol|cholesterol catabolic process|intracellular protein transport|receptor-mediated endocytosis|signal transduction|protein C-terminus binding|endosome membrane|membrane|endosomal transport|regulation of endocytosis|cytoplasmic vesicle membrane|cytoplasmic vesicle|phosphatidylinositol binding|aorta development|intracellular membrane-bounded organelle|protein complex|low-density lipoprotein particle receptor binding|coronary vasculature development|retrograde transport, endosome to plasma membrane SNX18 1125.98601559422 1186.66100418318 1065.31102700526 0.897738295309155 -0.155633156698925 0.308608640866691 1 7.56531 7.11606 7.48247 5.79006 GeneID:112574,Genbank:XM_017008997.1,HGNC:HGNC:19245 sorting nexin 18 GO:0000281,GO:0005546,GO:0006897,GO:0010008,GO:0015031,GO:0016197,GO:0030426,GO:0030659,GO:0031234,GO:0031410,GO:0035091,GO:0036089,GO:0043025,GO:0043547,GO:0070062 mitotic cytokinesis|phosphatidylinositol-4,5-bisphosphate binding|endocytosis|endosome membrane|protein transport|endosomal transport|growth cone|cytoplasmic vesicle membrane|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|phosphatidylinositol binding|cleavage furrow formation|neuronal cell body|positive regulation of GTPase activity|extracellular exosome SNX19 2237.7026519399 2168.45763004224 2306.94767383756 1.06386569046896 0.0893160268493156 0.515288274622925 1 4.72174 4.55214 5.42888 4.53094 GeneID:399979,Genbank:XM_011542821.3,HGNC:HGNC:21532 sorting nexin 19 GO:0002062,GO:0005737,GO:0006887,GO:0030073,GO:0030659,GO:0031901,GO:0032266,GO:1990502 chondrocyte differentiation|cytoplasm|exocytosis|insulin secretion|cytoplasmic vesicle membrane|early endosome membrane|phosphatidylinositol-3-phosphate binding|dense core granule maturation SNX2 739.793667500004 772.000073548332 707.587261451677 0.916563722849668 -0.125692909219433 0.560833295214823 1 3.85807 3.14849 3.61948 3.18869 GeneID:6643,Genbank:NM_001278199.1,HGNC:HGNC:11173,MIM:605929 sorting nexin 2 GO:0005154,GO:0005158,GO:0005737,GO:0005764,GO:0005768,GO:0005829,GO:0006886,GO:0006897,GO:0010008,GO:0016020,GO:0016050,GO:0019898,GO:0030027,GO:0030904,GO:0030905,GO:0031901,GO:0034498,GO:0035091,GO:0042147,GO:0042803,GO:0043234,GO:0045296,GO:0046982,GO:0051259,GO:0070062,GO:0072673,GO:1990459,GO:1990460 epidermal growth factor receptor binding|insulin receptor binding|cytoplasm|lysosome|endosome|cytosol|intracellular protein transport|endocytosis|endosome membrane|membrane|vesicle organization|extrinsic component of membrane|lamellipodium|retromer complex|retromer, tubulation complex|early endosome membrane|early endosome to Golgi transport|phosphatidylinositol binding|retrograde transport, endosome to Golgi|protein homodimerization activity|protein complex|cadherin binding|protein heterodimerization activity|protein oligomerization|extracellular exosome|lamellipodium morphogenesis|transferrin receptor binding|leptin receptor binding hsa04144 Endocytosis SNX21 510.788224277309 491.427618951918 530.148829602699 1.07879331392355 0.10941848527048 0.561686801855565 1 2.88473 3.40955 3.22752 3.5975 GeneID:90203,Genbank:XM_011529098.2,HGNC:HGNC:16154 sorting nexin family member 21 GO:0005546,GO:0015031,GO:0030659,GO:0031901,GO:0032266 phosphatidylinositol-4,5-bisphosphate binding|protein transport|cytoplasmic vesicle membrane|early endosome membrane|phosphatidylinositol-3-phosphate binding SNX22 1031.98904329677 1067.80601022757 996.172076365965 0.932914842981326 -0.100182697856988 0.803337761843184 1 2.75757 2.54679 2.06917 3.46906 GeneID:79856,Genbank:XM_005254677.3,HGNC:HGNC:16315 sorting nexin 22 GO:0015031,GO:0030659,GO:0035091 protein transport|cytoplasmic vesicle membrane|phosphatidylinositol binding SNX24 640.997739546893 620.466217142448 661.529261951337 1.06618095179783 0.0924523124936848 0.56070114068552 1 3.41531 3.1464 3.70693 3.16522 GeneID:28966,Genbank:NM_014035.3,HGNC:HGNC:21533 sorting nexin 24 GO:0010314,GO:0015031,GO:0030659,GO:0032266,GO:0070273 phosphatidylinositol-5-phosphate binding|protein transport|cytoplasmic vesicle membrane|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding SNX25 272.430834012448 283.640395524561 261.221272500334 0.920959343669067 -0.118790625847269 0.56874695452946 1 0.777141 0.881475 0.807565 0.705247 GeneID:83891,Genbank:NM_001317781.1,HGNC:HGNC:21883 sorting nexin 25 GO:0010008,GO:0015031,GO:0030512,GO:0032801,GO:0034713,GO:0035091,GO:0043231,GO:0060394 endosome membrane|protein transport|negative regulation of transforming growth factor beta receptor signaling pathway|receptor catabolic process|type I transforming growth factor beta receptor binding|phosphatidylinositol binding|intracellular membrane-bounded organelle|negative regulation of pathway-restricted SMAD protein phosphorylation SNX27 666.039177328338 696.195944726668 635.882409930008 0.913367012184567 -0.130733409634799 0.427319472814531 1 3.64971 3.78473 3.83317 3.04417 GeneID:81609,Genbank:XM_005245511.4,HGNC:HGNC:20073,MIM:611541 sorting nexin family member 27 GO:0001770,GO:0001772,GO:0005654,GO:0005768,GO:0005769,GO:0005829,GO:0006886,GO:0007165,GO:0008333,GO:0016197,GO:0031901,GO:0032266,GO:1990126 establishment of natural killer cell polarity|immunological synapse|nucleoplasm|endosome|early endosome|cytosol|intracellular protein transport|signal transduction|endosome to lysosome transport|endosomal transport|early endosome membrane|phosphatidylinositol-3-phosphate binding|retrograde transport, endosome to plasma membrane SNX29 207.419865607927 224.880870565217 189.958860650637 0.844708845946713 -0.243473935612379 0.28467460168286 1 0.426451 0.379971 0.30666 0.359202 GeneID:92017,Genbank:NM_032167.4,HGNC:HGNC:30542 sorting nexin 29 GO:0035091,GO:0070062 phosphatidylinositol binding|extracellular exosome SNX3 5894.71094812415 5802.36804005074 5987.05385619755 1.03182938670419 0.0452044404272922 0.737290005154235 1 179.437 190.359 194.483 189.282 GeneID:8724,Genbank:NM_001300929.1,HGNC:HGNC:11174,MIM:605930 sorting nexin 3 GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0006783,GO:0006897,GO:0009617,GO:0010008,GO:0010314,GO:0010324,GO:0010976,GO:0016050,GO:0019898,GO:0019903,GO:0022615,GO:0030111,GO:0030136,GO:0031901,GO:0032009,GO:0032266,GO:0032268,GO:0033157,GO:0033572,GO:0042177,GO:0042541,GO:0046597,GO:0050765,GO:0051224,GO:0070273,GO:0070676,GO:0080025,GO:2000642 cytoplasm|endosome|early endosome|cytosol|heme biosynthetic process|endocytosis|response to bacterium|endosome membrane|phosphatidylinositol-5-phosphate binding|membrane invagination|positive regulation of neuron projection development|vesicle organization|extrinsic component of membrane|protein phosphatase binding|protein to membrane docking|regulation of Wnt signaling pathway|clathrin-coated vesicle|early endosome membrane|early phagosome|phosphatidylinositol-3-phosphate binding|regulation of cellular protein metabolic process|regulation of intracellular protein transport|transferrin transport|negative regulation of protein catabolic process|hemoglobin biosynthetic process|negative regulation of viral entry into host cell|negative regulation of phagocytosis|negative regulation of protein transport|phosphatidylinositol-4-phosphate binding|intralumenal vesicle formation|phosphatidylinositol-3,5-bisphosphate binding|negative regulation of early endosome to late endosome transport hsa04144 Endocytosis SNX30 437.234825076761 461.542055086772 412.92759506675 0.894669490062216 -0.16057327632278 0.388516044934422 1 2.38972 2.16129 2.20953 1.84926 GeneID:401548,Genbank:XM_024447544.1,HGNC:HGNC:23685 sorting nexin family member 30 GO:0005768,GO:0006897,GO:0015031,GO:0016050,GO:0019898,GO:0035091 endosome|endocytosis|protein transport|vesicle organization|extrinsic component of membrane|phosphatidylinositol binding SNX32 276.257053972925 294.74834163531 257.76576631054 0.874528300584883 -0.19342302297277 0.585282416203944 1 1.46139 1.41178 0.880817 1.58171 GeneID:254122,Genbank:XM_024448419.1,HGNC:HGNC:26423 sorting nexin 32 GO:0005768,GO:0006897,GO:0015031,GO:0016050,GO:0016241,GO:0019898,GO:0035091 endosome|endocytosis|protein transport|vesicle organization|regulation of macroautophagy|extrinsic component of membrane|phosphatidylinositol binding hsa04144 Endocytosis SNX33 418.190510135848 398.276851961297 438.104168310399 1.09999907389288 0.137502309122017 0.46346575310306 1 4.28948 4.58002 5.11314 4.84754 GeneID:257364,Genbank:NM_153271.1,HGNC:HGNC:28468 sorting nexin 33 GO:0000281,GO:0005829,GO:0006886,GO:0006897,GO:0007032,GO:0016020,GO:0016197,GO:0017038,GO:0019898,GO:0030659,GO:0031410,GO:0035091,GO:0036089,GO:0042802,GO:0044351,GO:0045806,GO:0051044,GO:0097320,GO:2000009,GO:2000010 mitotic cytokinesis|cytosol|intracellular protein transport|endocytosis|endosome organization|membrane|endosomal transport|protein import|extrinsic component of membrane|cytoplasmic vesicle membrane|cytoplasmic vesicle|phosphatidylinositol binding|cleavage furrow formation|identical protein binding|macropinocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis|plasma membrane tubulation|negative regulation of protein localization to cell surface|positive regulation of protein localization to cell surface SNX4 329.522338328562 335.279172172861 323.765504484264 0.965659460401372 -0.0504135822315787 0.816756708470481 1 4.69122 4.44265 4.95608 3.86368 GeneID:8723,Genbank:NM_003794.3,HGNC:HGNC:11175,MIM:605931 sorting nexin 4 GO:0005154,GO:0005158,GO:0005737,GO:0005868,GO:0005886,GO:0006897,GO:0015031,GO:0016020,GO:0016050,GO:0019898,GO:0031201,GO:0031901,GO:0032456,GO:0035091,GO:0043234,GO:1903595,GO:1990459,GO:1990460 epidermal growth factor receptor binding|insulin receptor binding|cytoplasm|cytoplasmic dynein complex|plasma membrane|endocytosis|protein transport|membrane|vesicle organization|extrinsic component of membrane|SNARE complex|early endosome membrane|endocytic recycling|phosphatidylinositol binding|protein complex|positive regulation of histamine secretion by mast cell|transferrin receptor binding|leptin receptor binding hsa04144 Endocytosis SNX5 1622.74320874071 1714.54499497783 1530.94142250359 0.892914112483467 -0.163406682646443 0.258243103239687 1 25.2325 25.5696 23.9051 22.606 GeneID:27131,Genbank:NM_001282454.1,HGNC:HGNC:14969,MIM:605937 sorting nexin 5 GO:0001726,GO:0001891,GO:0005829,GO:0006886,GO:0006907,GO:0016050,GO:0016241,GO:0030659,GO:0030904,GO:0030905,GO:0031234,GO:0031313,GO:0031901,GO:0034452,GO:0035091,GO:0042147,GO:0045296,GO:0046982,GO:0070685,GO:0097422 ruffle|phagocytic cup|cytosol|intracellular protein transport|pinocytosis|vesicle organization|regulation of macroautophagy|cytoplasmic vesicle membrane|retromer complex|retromer, tubulation complex|extrinsic component of cytoplasmic side of plasma membrane|extrinsic component of endosome membrane|early endosome membrane|dynactin binding|phosphatidylinositol binding|retrograde transport, endosome to Golgi|cadherin binding|protein heterodimerization activity|macropinocytic cup|tubular endosome hsa04144 Endocytosis SNX6 789.330067254118 822.553863189094 756.106271319141 0.919217944448852 -0.121521133158037 0.581082119482259 1 10.5582 9.35334 10.5481 7.52337 GeneID:58533,Genbank:NM_152233.3,HGNC:HGNC:14970,MIM:606098 sorting nexin 6 GO:0005622,GO:0005634,GO:0005737,GO:0005829,GO:0006886,GO:0006897,GO:0007175,GO:0016050,GO:0016241,GO:0019898,GO:0030512,GO:0030904,GO:0030905,GO:0031901,GO:0034452,GO:0035091,GO:0042147,GO:0042803,GO:0045892,GO:0046982,GO:0097422 intracellular|nucleus|cytoplasm|cytosol|intracellular protein transport|endocytosis|negative regulation of epidermal growth factor-activated receptor activity|vesicle organization|regulation of macroautophagy|extrinsic component of membrane|negative regulation of transforming growth factor beta receptor signaling pathway|retromer complex|retromer, tubulation complex|early endosome membrane|dynactin binding|phosphatidylinositol binding|retrograde transport, endosome to Golgi|protein homodimerization activity|negative regulation of transcription, DNA-templated|protein heterodimerization activity|tubular endosome hsa04144 Endocytosis SNX7 1666.43354298729 1605.6835341601 1727.18355181448 1.07566871993735 0.105233830968533 0.454355795180917 1 22.2578 21.6675 24.4321 24.1665 GeneID:51375,Genbank:XM_017001425.2,HGNC:HGNC:14971,MIM:614904 sorting nexin 7 GO:0005768,GO:0006897,GO:0015031,GO:0016050,GO:0019898,GO:0030659,GO:0035091 endosome|endocytosis|protein transport|vesicle organization|extrinsic component of membrane|cytoplasmic vesicle membrane|phosphatidylinositol binding SNX8 2777.79877953959 2649.88495820372 2905.71260087546 1.09654292420496 0.132962287456613 0.345792779342644 1 19.3366 20.5525 21.9966 22.8949 GeneID:29886,Genbank:XM_017012084.2,HGNC:HGNC:14972,MIM:614905 sorting nexin 8 GO:0005829,GO:0006886,GO:0006897,GO:0016050,GO:0019898,GO:0031901,GO:0034498,GO:0035091,GO:0042802,GO:0043231 cytosol|intracellular protein transport|endocytosis|vesicle organization|extrinsic component of membrane|early endosome membrane|early endosome to Golgi transport|phosphatidylinositol binding|identical protein binding|intracellular membrane-bounded organelle SNX9 1895.76641264914 1899.50956792129 1892.02325737699 0.996058819249596 -0.00569715607379775 0.978900759282499 1 14.7468 14.2211 15.3834 13.9576 GeneID:51429,Genbank:XM_005267015.2,HGNC:HGNC:14973,MIM:605952 sorting nexin 9 GO:0000281,GO:0001726,GO:0005545,GO:0005737,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0006897,GO:0006898,GO:0016197,GO:0030136,GO:0030659,GO:0031234,GO:0031410,GO:0031625,GO:0032461,GO:0035091,GO:0036089,GO:0042802,GO:0042803,GO:0043547,GO:0045296,GO:0045860,GO:0051044,GO:0060988,GO:0061024,GO:0070062,GO:0071933,GO:0097320 mitotic cytokinesis|ruffle|1-phosphatidylinositol binding|cytoplasm|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|endocytosis|receptor-mediated endocytosis|endosomal transport|clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic vesicle|ubiquitin protein ligase binding|positive regulation of protein oligomerization|phosphatidylinositol binding|cleavage furrow formation|identical protein binding|protein homodimerization activity|positive regulation of GTPase activity|cadherin binding|positive regulation of protein kinase activity|positive regulation of membrane protein ectodomain proteolysis|lipid tube assembly|membrane organization|extracellular exosome|Arp2/3 complex binding|plasma membrane tubulation SOAT1 1203.0270102061 1234.11844393132 1171.93557648088 0.949613533647258 -0.0745875988432504 0.753477919511882 1 8.14446 7.00265 8.1898 6.35255 GeneID:6646,Genbank:NM_003101.5,HGNC:HGNC:11177,MIM:102642 sterol O-acyltransferase 1 GO:0000062,GO:0004772,GO:0005783,GO:0005789,GO:0008203,GO:0010742,GO:0010878,GO:0015485,GO:0016020,GO:0016021,GO:0033344,GO:0034379,GO:0034383,GO:0034435,GO:0034736,GO:0042632,GO:0042986 fatty-acyl-CoA binding|sterol O-acyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol metabolic process|macrophage derived foam cell differentiation|cholesterol storage|cholesterol binding|membrane|integral component of membrane|cholesterol efflux|very-low-density lipoprotein particle assembly|low-density lipoprotein particle clearance|cholesterol esterification|cholesterol O-acyltransferase activity|cholesterol homeostasis|positive regulation of amyloid precursor protein biosynthetic process hsa00100,hsa04979 Steroid biosynthesis|Cholesterol metabolism SOAT2 1.80379780716536 2.15239070656922 1.45520490776151 0.676087711826734 -0.564717669077069 0.971494676615895 1 0 0 0.0218406 0 GeneID:8435,Genbank:NM_003578.3,HGNC:HGNC:11178,MIM:601311 sterol O-acyltransferase 2 GO:0000062,GO:0005783,GO:0005789,GO:0005903,GO:0008203,GO:0010742,GO:0015485,GO:0016021,GO:0016746,GO:0030299,GO:0033344,GO:0034379,GO:0034383,GO:0034435,GO:0034736,GO:0042632 fatty-acyl-CoA binding|endoplasmic reticulum|endoplasmic reticulum membrane|brush border|cholesterol metabolic process|macrophage derived foam cell differentiation|cholesterol binding|integral component of membrane|transferase activity, transferring acyl groups|intestinal cholesterol absorption|cholesterol efflux|very-low-density lipoprotein particle assembly|low-density lipoprotein particle clearance|cholesterol esterification|cholesterol O-acyltransferase activity|cholesterol homeostasis hsa00100,hsa04979 Steroid biosynthesis|Cholesterol metabolism SOBP 66.2376106925422 48.6219129974019 83.8533083876824 1.72459912040407 0.786261049300872 0.0284731158234588 0.6711497109187 0.129382 0.174313 0.414503 0.254481 GeneID:55084,Genbank:XM_005267042.4,HGNC:HGNC:29256,MIM:613667 sine oculis binding protein homolog GO:0005634,GO:0007605,GO:0007626,GO:0032184,GO:0042472,GO:0046872,GO:0050890,GO:0090102 nucleus|sensory perception of sound|locomotory behavior|SUMO polymer binding|inner ear morphogenesis|metal ion binding|cognition|cochlea development SOCS1 15.4578106397883 17.8248669140969 13.0907543654798 0.734409655262387 -0.445343068941199 0.552230195923183 1 1.16926 1.4814 1.63059 0.534512 GeneID:8651,Genbank:NM_003745.1,HGNC:HGNC:19383,MIM:603597 suppressor of cytokine signaling 1 hsa04120,hsa04380,hsa04630,hsa04910,hsa04917,hsa04930,hsa05145,hsa05206 Ubiquitin mediated proteolysis|Osteoclast differentiation|Jak-STAT signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Type II diabetes mellitus|Toxoplasmosis|MicroRNAs in cancer SOCS2 814.885127036604 1060.81074043122 568.959513641993 0.536344035704912 -0.898769386398111 1.83333672454433e-08 2.25867084463861e-05 8.42225 7.55271 4.387 4.24023 GeneID:8835,Genbank:NM_003877.4,HGNC:HGNC:19382,MIM:605117 suppressor of cytokine signaling 2 hsa04630,hsa04910,hsa04917,hsa04930 Jak-STAT signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Type II diabetes mellitus SOCS3 498.751500439917 439.211510006544 558.291490873289 1.27112217725116 0.346102705435734 0.0494115888092107 0.813062736622003 7.04604 7.3838 9.60168 9.17823 GeneID:9021,Genbank:NM_003955.4,HGNC:HGNC:19391,MIM:604176 suppressor of cytokine signaling 3 hsa04120,hsa04380,hsa04630,hsa04668,hsa04910,hsa04917,hsa04920,hsa04930,hsa04931,hsa04932,hsa05160,hsa05164,hsa05168 Ubiquitin mediated proteolysis|Osteoclast differentiation|Jak-STAT signaling pathway|TNF signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Hepatitis C|Influenza A|Herpes simplex infection SOCS4 278.166592525748 299.907787337669 256.425397713827 0.855014136145504 -0.225979822282482 0.57267703384494 1 2.08543 1.72378 2.07464 1.16932 GeneID:122809,Genbank:NM_199421.1,HGNC:HGNC:19392,MIM:616337 suppressor of cytokine signaling 4 GO:0004860,GO:0005737,GO:0007175,GO:0016567,GO:0019221,GO:0032436,GO:0035556,GO:0040008,GO:0046426 protein kinase inhibitor activity|cytoplasm|negative regulation of epidermal growth factor-activated receptor activity|protein ubiquitination|cytokine-mediated signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|intracellular signal transduction|regulation of growth|negative regulation of JAK-STAT cascade hsa04630,hsa04910,hsa04917,hsa04930 Jak-STAT signaling pathway|Insulin signaling pathway|Prolactin signaling pathway|Type II diabetes mellitus SOCS5 467.201006033363 466.211429387174 468.190582679551 1.00424518398225 0.00611154272609003 0.952106773840373 1 5.27589 4.21966 5.39661 4.26795 GeneID:9655,Genbank:NM_014011.4,HGNC:HGNC:16852,MIM:607094 suppressor of cytokine signaling 5 GO:0004860,GO:0005154,GO:0005737,GO:0005829,GO:0007173,GO:0007175,GO:0007259,GO:0009968,GO:0016049,GO:0016567,GO:0019221,GO:0030971,GO:0032436,GO:0032715,GO:0040008,GO:0043687,GO:0045627,GO:0045629,GO:0046426,GO:0050728,GO:0071404,GO:0071638,GO:0097699 protein kinase inhibitor activity|epidermal growth factor receptor binding|cytoplasm|cytosol|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor-activated receptor activity|JAK-STAT cascade|negative regulation of signal transduction|cell growth|protein ubiquitination|cytokine-mediated signaling pathway|receptor tyrosine kinase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of interleukin-6 production|regulation of growth|post-translational protein modification|positive regulation of T-helper 1 cell differentiation|negative regulation of T-helper 2 cell differentiation|negative regulation of JAK-STAT cascade|negative regulation of inflammatory response|cellular response to low-density lipoprotein particle stimulus|negative regulation of monocyte chemotactic protein-1 production|vascular endothelial cell response to fluid shear stress hsa04630,hsa04917 Jak-STAT signaling pathway|Prolactin signaling pathway SOCS6 165.284266377409 163.334804673292 167.233728081525 1.02387074460971 0.0340335982669825 0.92834681757678 1 1.14923 1.16881 1.54527 0.897986 GeneID:9306,Genbank:NM_004232.3,HGNC:HGNC:16833,MIM:605118 suppressor of cytokine signaling 6 GO:0001772,GO:0004860,GO:0005737,GO:0005829,GO:0006469,GO:0006952,GO:0007259,GO:0010498,GO:0016567,GO:0019221,GO:0040008,GO:0043687,GO:0046426,GO:0050868 immunological synapse|protein kinase inhibitor activity|cytoplasm|cytosol|negative regulation of protein kinase activity|defense response|JAK-STAT cascade|proteasomal protein catabolic process|protein ubiquitination|cytokine-mediated signaling pathway|regulation of growth|post-translational protein modification|negative regulation of JAK-STAT cascade|negative regulation of T cell activation hsa04630,hsa04917 Jak-STAT signaling pathway|Prolactin signaling pathway SOCS7 1075.97153942186 1141.98029671251 1009.96278213122 0.884395978668519 -0.177235629624874 0.236121092351149 1 5.96235 6.22427 5.50728 5.35447 GeneID:30837,Genbank:XM_017024551.1,HGNC:HGNC:29846,MIM:608788 suppressor of cytokine signaling 7 GO:0004860,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006469,GO:0008286,GO:0016567,GO:0017124,GO:0019221,GO:0021819,GO:0021942,GO:0035556,GO:0040008,GO:0045444,GO:0046426 protein kinase inhibitor activity|nucleus|cytoplasm|cytosol|plasma membrane|negative regulation of protein kinase activity|insulin receptor signaling pathway|protein ubiquitination|SH3 domain binding|cytokine-mediated signaling pathway|layer formation in cerebral cortex|radial glia guided migration of Purkinje cell|intracellular signal transduction|regulation of growth|fat cell differentiation|negative regulation of JAK-STAT cascade hsa04630,hsa04917 Jak-STAT signaling pathway|Prolactin signaling pathway SOD1 3441.2704734466 3496.55716429235 3385.98378260086 0.968376498224969 -0.0463600282577837 0.7272788618836 1 159.122 167.112 157.645 159.311 GeneID:6647,Genbank:NM_000454.4,HGNC:HGNC:11179,MIM:147450 superoxide dismutase 1 hsa04146,hsa04213,hsa05014,hsa05016,hsa05020 Peroxisome|Longevity regulating pathway - multiple species|Amyotrophic lateral sclerosis (ALS)|Huntington disease|Prion diseases SOD2 2754.51700500002 2641.93286956365 2867.10114043639 1.0852286117739 0.117998989518413 0.37462401066424 1 14.1786 13.1415 15.9454 14.4836 GeneID:6648,Genbank:NM_001322817.1,HGNC:HGNC:11180,MIM:147460 superoxide dismutase 2 GO:0001315,GO:0004784,GO:0005759,GO:0006357,GO:0006801,GO:0030145 age-dependent response to reactive oxygen species|superoxide dismutase activity|mitochondrial matrix|regulation of transcription from RNA polymerase II promoter|superoxide metabolic process|manganese ion binding hsa04068,hsa04146,hsa04211,hsa04213,hsa05016 FoxO signaling pathway|Peroxisome|Longevity regulating pathway|Longevity regulating pathway - multiple species|Huntington disease SOGA1 4709.84921532344 4426.35042061585 4993.34801003103 1.1280959561571 0.17388978899925 0.195794272564618 1 12.5034 12.7055 15.3717 13.3595 GeneID:140710,Genbank:NM_080627.3,HGNC:HGNC:16111 suppressor of glucose, autophagy associated 1 GO:0005615,GO:0008286,GO:0010506,GO:0045721,GO:0070062 extracellular space|insulin receptor signaling pathway|regulation of autophagy|negative regulation of gluconeogenesis|extracellular exosome SOGA3 97.8846346506419 92.525408418862 103.243860882422 1.11584334126943 0.158134494337043 0.652650429484911 1 0.725545 0.589979 0.908829 0.592466 GeneID:387104,Genbank:NM_001012279.2,HGNC:HGNC:21494 SOGA family member 3 SOHLH1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0109271 0 0 0 GeneID:402381,Genbank:XM_011518698.3,HGNC:HGNC:27845,MIM:610224 spermatogenesis and oogenesis specific basic helix-loop-helix 1 GO:0001046,GO:0001228,GO:0005634,GO:0005737,GO:0006366,GO:0007275,GO:0007283,GO:0030154,GO:0046983,GO:0048477 core promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|cytoplasm|transcription from RNA polymerase II promoter|multicellular organism development|spermatogenesis|cell differentiation|protein dimerization activity|oogenesis SOHLH2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 1.04244e-07 1.53837e-07 0.0303856 1.0096e-07 GeneID:54937,Genbank:NM_017826.2,HGNC:HGNC:26026,MIM:616066 spermatogenesis and oogenesis specific basic helix-loop-helix 2 GO:0001046,GO:0001228,GO:0005634,GO:0006366,GO:0007275,GO:0007283,GO:0030154,GO:0046983,GO:0048477 core promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|transcription from RNA polymerase II promoter|multicellular organism development|spermatogenesis|cell differentiation|protein dimerization activity|oogenesis SON 4168.61683291581 4191.25920949951 4145.97445633212 0.989195430083456 -0.015672520152601 0.944042807949736 1 14.5906 13.6352 16.2644 11.8486 GeneID:6651,Genbank:NM_138927.2,HGNC:HGNC:11183,MIM:182465 SON DNA binding protein GO:0000226,GO:0000281,GO:0003677,GO:0003723,GO:0006397,GO:0008380,GO:0016607,GO:0043066,GO:0043484,GO:0048024,GO:0050733,GO:0051726 microtubule cytoskeleton organization|mitotic cytokinesis|DNA binding|RNA binding|mRNA processing|RNA splicing|nuclear speck|negative regulation of apoptotic process|regulation of RNA splicing|regulation of mRNA splicing, via spliceosome|RS domain binding|regulation of cell cycle SORBS1 535.646471339962 501.285864920004 570.00707775992 1.13708986757662 0.185346279193772 0.443065118846066 1 1.62339 1.6926 2.31922 1.64427 GeneID:10580,Genbank:XM_017015526.2,HGNC:HGNC:14565,MIM:605264 sorbin and SH3 domain containing 1 GO:0001725,GO:0003779,GO:0005070,GO:0005158,GO:0005634,GO:0005813,GO:0005829,GO:0005886,GO:0005913,GO:0005915,GO:0005924,GO:0005925,GO:0006936,GO:0007160,GO:0008092,GO:0008286,GO:0015758,GO:0016363,GO:0032869,GO:0043149,GO:0045121,GO:0045725,GO:0046326,GO:0046889,GO:0048041,GO:1903078 stress fiber|actin binding|SH3/SH2 adaptor activity|insulin receptor binding|nucleus|centrosome|cytosol|plasma membrane|cell-cell adherens junction|zonula adherens|cell-substrate adherens junction|focal adhesion|muscle contraction|cell-matrix adhesion|cytoskeletal protein binding|insulin receptor signaling pathway|glucose transport|nuclear matrix|cellular response to insulin stimulus|stress fiber assembly|membrane raft|positive regulation of glycogen biosynthetic process|positive regulation of glucose import|positive regulation of lipid biosynthetic process|focal adhesion assembly|positive regulation of protein localization to plasma membrane hsa03320,hsa04520,hsa04910 PPAR signaling pathway|Adherens junction|Insulin signaling pathway SORBS2 164.942725471842 167.533724881953 162.351726061731 0.969068921353758 -0.0453288193818721 0.888880847033798 1 0.249137 0.200603 0.243875 0.239305 GeneID:8470,Genbank:NM_021069.4,HGNC:HGNC:24098,MIM:616349 sorbin and SH3 domain containing 2 GO:0003676,GO:0005654,GO:0005856,GO:0005886,GO:0005925,GO:0007015,GO:0007219,GO:0016324,GO:0019904,GO:0030018,GO:0030027,GO:0046983,GO:0048471 nucleic acid binding|nucleoplasm|cytoskeleton|plasma membrane|focal adhesion|actin filament organization|Notch signaling pathway|apical plasma membrane|protein domain specific binding|Z disc|lamellipodium|protein dimerization activity|perinuclear region of cytoplasm SORBS3 1915.25616194704 1917.29047656412 1913.22184732996 0.9978779275838 -0.00306475632000349 0.955723343344516 1 14.0606 15.9733 14.5984 15.8824 GeneID:10174,Genbank:XM_006716266.1,HGNC:HGNC:30907,MIM:610795 sorbin and SH3 domain containing 3 GO:0000122,GO:0005200,GO:0005634,GO:0005829,GO:0005856,GO:0005925,GO:0006936,GO:0007015,GO:0007155,GO:0008134,GO:0017166,GO:0031589,GO:0043410,GO:0051495,GO:0051496 negative regulation of transcription from RNA polymerase II promoter|structural constituent of cytoskeleton|nucleus|cytosol|cytoskeleton|focal adhesion|muscle contraction|actin filament organization|cell adhesion|transcription factor binding|vinculin binding|cell-substrate adhesion|positive regulation of MAPK cascade|positive regulation of cytoskeleton organization|positive regulation of stress fiber assembly SORCS1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:114815,Genbank:XM_017015617.1,HGNC:HGNC:16697,MIM:606283 sortilin related VPS10 domain containing receptor 1 GO:0007218,GO:0008188,GO:0016020,GO:0016021 neuropeptide signaling pathway|neuropeptide receptor activity|membrane|integral component of membrane SORCS2 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0 0.00496816 GeneID:57537,Genbank:XM_005247987.4,HGNC:HGNC:16698,MIM:606284 sortilin related VPS10 domain containing receptor 2 GO:0007218,GO:0008188,GO:0016020,GO:0016021 neuropeptide signaling pathway|neuropeptide receptor activity|membrane|integral component of membrane SORCS3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00720512 0 0 0 GeneID:22986,Genbank:NM_014978.2,HGNC:HGNC:16699,MIM:606285 sortilin related VPS10 domain containing receptor 3 GO:0007218,GO:0007612,GO:0007613,GO:0008188,GO:0014069,GO:0016020,GO:0016021,GO:1900452 neuropeptide signaling pathway|learning|memory|neuropeptide receptor activity|postsynaptic density|membrane|integral component of membrane|regulation of long term synaptic depression SORD 875.323910669714 901.579820418068 849.068000921359 0.941755773246611 -0.0865751225323474 0.586948579414582 1 13.0585 12.8815 12.6253 11.9242 GeneID:6652,Genbank:NM_003104.5,HGNC:HGNC:11184,MIM:182500 sorbitol dehydrogenase GO:0003939,GO:0005615,GO:0005829,GO:0006006,GO:0006062,GO:0006970,GO:0008270,GO:0009725,GO:0016020,GO:0019640,GO:0030246,GO:0030317,GO:0031514,GO:0031667,GO:0031966,GO:0042493,GO:0042802,GO:0046370,GO:0046526,GO:0046686,GO:0046688,GO:0051160,GO:0051164,GO:0051287,GO:0070062 L-iditol 2-dehydrogenase activity|extracellular space|cytosol|glucose metabolic process|sorbitol catabolic process|response to osmotic stress|zinc ion binding|response to hormone|membrane|glucuronate catabolic process to xylulose 5-phosphate|carbohydrate binding|flagellated sperm motility|motile cilium|response to nutrient levels|mitochondrial membrane|response to drug|identical protein binding|fructose biosynthetic process|D-xylulose reductase activity|response to cadmium ion|response to copper ion|L-xylitol catabolic process|L-xylitol metabolic process|NAD binding|extracellular exosome hsa00040,hsa00051 Pentose and glucuronate interconversions|Fructose and mannose metabolism SORL1 995.989436442538 937.277580520947 1054.70129236413 1.12528168205828 0.170286184056876 0.453913607668286 1 2.52541 2.53028 3.45582 2.35879 GeneID:6653,Genbank:NM_003105.5,HGNC:HGNC:11185,MIM:602005 sortilin related receptor 1 GO:0000042,GO:0000139,GO:0001540,GO:0004888,GO:0005041,GO:0005615,GO:0005641,GO:0005768,GO:0005769,GO:0005783,GO:0005794,GO:0005802,GO:0005887,GO:0006605,GO:0006622,GO:0006869,GO:0006892,GO:0006898,GO:0008203,GO:0010008,GO:0014910,GO:0016020,GO:0030169,GO:0030306,GO:0031985,GO:0032091,GO:0032460,GO:0034362,GO:0043407,GO:0044267,GO:0045053,GO:0045732,GO:0050768,GO:0051604,GO:0055037,GO:0070062,GO:0070863,GO:1901215,GO:1902430,GO:1902771,GO:1902948,GO:1902953,GO:1902955,GO:1902960,GO:1902963,GO:1902966,GO:1902997,GO:2001137 protein targeting to Golgi|Golgi membrane|amyloid-beta binding|transmembrane signaling receptor activity|low-density lipoprotein receptor activity|extracellular space|nuclear envelope lumen|endosome|early endosome|endoplasmic reticulum|Golgi apparatus|trans-Golgi network|integral component of plasma membrane|protein targeting|protein targeting to lysosome|lipid transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|cholesterol metabolic process|endosome membrane|regulation of smooth muscle cell migration|membrane|low-density lipoprotein particle binding|ADP-ribosylation factor binding|Golgi cisterna|negative regulation of protein binding|negative regulation of protein oligomerization|low-density lipoprotein particle|negative regulation of MAP kinase activity|cellular protein metabolic process|protein retention in Golgi apparatus|positive regulation of protein catabolic process|negative regulation of neurogenesis|protein maturation|recycling endosome|extracellular exosome|positive regulation of protein exit from endoplasmic reticulum|negative regulation of neuron death|negative regulation of amyloid-beta formation|positive regulation of choline O-acetyltransferase activity|negative regulation of tau-protein kinase activity|positive regulation of ER to Golgi vesicle-mediated transport|positive regulation of early endosome to recycling endosome transport|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of protein localization to early endosome|negative regulation of neurofibrillary tangle assembly|positive regulation of endocytic recycling SORT1 8877.81025553185 8188.89930795717 9566.72120310655 1.16825483417662 0.224355007010723 0.083457973008648 0.963076417285947 39.8042 39.1244 51.5519 42.5289 GeneID:6272,Genbank:NM_002959.6,HGNC:HGNC:11186,MIM:602458 sortilin 1 GO:0001503,GO:0005765,GO:0005769,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0005905,GO:0006895,GO:0006897,GO:0007186,GO:0007218,GO:0007275,GO:0008333,GO:0008625,GO:0009986,GO:0010008,GO:0010465,GO:0010468,GO:0014902,GO:0016021,GO:0016050,GO:0019899,GO:0030136,GO:0030140,GO:0030379,GO:0030425,GO:0030659,GO:0031410,GO:0031965,GO:0032509,GO:0032580,GO:0032868,GO:0043025,GO:0045599,GO:0046323,GO:0048011,GO:0048227,GO:0048406,GO:0048471,GO:0051005,GO:1904037 ossification|lysosomal membrane|early endosome|endoplasmic reticulum membrane|Golgi apparatus|cytosol|plasma membrane|clathrin-coated pit|Golgi to endosome transport|endocytosis|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|multicellular organism development|endosome to lysosome transport|extrinsic apoptotic signaling pathway via death domain receptors|cell surface|endosome membrane|nerve growth factor receptor activity|regulation of gene expression|myotube differentiation|integral component of membrane|vesicle organization|enzyme binding|clathrin-coated vesicle|trans-Golgi network transport vesicle|neurotensin receptor activity, non-G-protein coupled|dendrite|cytoplasmic vesicle membrane|cytoplasmic vesicle|nuclear membrane|endosome transport via multivesicular body sorting pathway|Golgi cisterna membrane|response to insulin|neuronal cell body|negative regulation of fat cell differentiation|glucose import|neurotrophin TRK receptor signaling pathway|plasma membrane to endosome transport|nerve growth factor binding|perinuclear region of cytoplasm|negative regulation of lipoprotein lipase activity|positive regulation of epithelial cell apoptotic process hsa04142,hsa04722,hsa04979 Lysosome|Neurotrophin signaling pathway|Cholesterol metabolism SOS1 279.717728710209 295.747084748586 263.688372671833 0.891600919400422 -0.165529990611651 0.653305046969115 1 1.25344 1.09241 1.29813 0.815149 GeneID:6654,Genbank:NM_005633.3,HGNC:HGNC:11187,MIM:182530 SOS Ras/Rac guanine nucleotide exchange factor 1 hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04062,hsa04068,hsa04072,hsa04150,hsa04151,hsa04510,hsa04540,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04722,hsa04810,hsa04910,hsa04912,hsa04915,hsa04917,hsa04926,hsa05034,hsa05160,hsa05163,hsa05165,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Alcoholism|Hepatitis C|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer SOS2 169.774387344956 167.965961354117 171.582813335795 1.02153324371509 0.0307361544015439 0.905642102134447 1 1.29354 1.00128 1.46409 0.973357 GeneID:6655,Genbank:NM_006939.3,HGNC:HGNC:11188,MIM:601247 SOS Ras/Rho guanine nucleotide exchange factor 2 hsa01521,hsa01522,hsa04010,hsa04012,hsa04014,hsa04062,hsa04068,hsa04072,hsa04150,hsa04151,hsa04510,hsa04540,hsa04630,hsa04650,hsa04660,hsa04662,hsa04664,hsa04714,hsa04722,hsa04810,hsa04910,hsa04912,hsa04915,hsa04917,hsa04926,hsa05034,hsa05160,hsa05163,hsa05165,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05213,hsa05214,hsa05215,hsa05220,hsa05221,hsa05223,hsa05224,hsa05225,hsa05226,hsa05231 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|Chemokine signaling pathway|FoxO signaling pathway|Phospholipase D signaling pathway|mTOR signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Gap junction|Jak-STAT signaling pathway|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Thermogenesis|Neurotrophin signaling pathway|Regulation of actin cytoskeleton|Insulin signaling pathway|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Relaxin signaling pathway|Alcoholism|Hepatitis C|Human cytomegalovirus infection|Human papillomavirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Endometrial cancer|Glioma|Prostate cancer|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Choline metabolism in cancer SOST 11.6416047499666 20.8613478752109 2.42186162472226 0.116093247627595 -3.1066440322229 0.00111271068432299 0.109332357792129 0.325889 0.45778 0.0190812 0.0711237 GeneID:50964,Genbank:NM_025237.2,HGNC:HGNC:13771,MIM:605740 sclerostin GO:0001503,GO:0005576,GO:0005578,GO:0005615,GO:0005794,GO:0008134,GO:0008201,GO:0009612,GO:0016055,GO:0030279,GO:0030514,GO:0031333,GO:0043234,GO:0045893,GO:0071374,GO:0090090,GO:2000054 ossification|extracellular region|proteinaceous extracellular matrix|extracellular space|Golgi apparatus|transcription factor binding|heparin binding|response to mechanical stimulus|Wnt signaling pathway|negative regulation of ossification|negative regulation of BMP signaling pathway|negative regulation of protein complex assembly|protein complex|positive regulation of transcription, DNA-templated|cellular response to parathyroid hormone stimulus|negative regulation of canonical Wnt signaling pathway|negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification hsa04310,hsa04928 Wnt signaling pathway|Parathyroid hormone synthesis, secretion and action SOSTDC1 2.72166664386287 1.56626675524197 3.87706653248377 2.4753551842354 1.30763554974577 0.556446753005391 1 0.0546975 0.0257089 0.103902 0.0485096 GeneID:25928,Genbank:NM_015464.2,HGNC:HGNC:21748,MIM:609675 sclerostin domain containing 1 GO:0005615,GO:0007389,GO:0010454,GO:0016055,GO:0030178,GO:0030514,GO:0031069,GO:0036122,GO:0042475,GO:0045662,GO:0060648,GO:0090090,GO:0098821,GO:2000016 extracellular space|pattern specification process|negative regulation of cell fate commitment|Wnt signaling pathway|negative regulation of Wnt signaling pathway|negative regulation of BMP signaling pathway|hair follicle morphogenesis|BMP binding|odontogenesis of dentin-containing tooth|negative regulation of myoblast differentiation|mammary gland bud morphogenesis|negative regulation of canonical Wnt signaling pathway|BMP receptor activity|negative regulation of determination of dorsal identity SOWAHA 6.22940320105852 5.18887166768327 7.26993473443377 1.40106273579891 0.486521557195979 0.725538114529446 1 0.119127 0.0708555 0.148936 0.121657 GeneID:134548,Genbank:NM_175873.5,HGNC:HGNC:27033 sosondowah ankyrin repeat domain family member A SOWAHB 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0264608 0 0 0 GeneID:345079,Genbank:NM_001029870.2,HGNC:HGNC:32958 sosondowah ankyrin repeat domain family member B SOWAHC 48.7334449682379 52.388596733898 45.0782932025777 0.860460023992393 -0.216819927058402 0.61556937675899 1 0.547171 0.499067 0.563532 0.36926 GeneID:65124,Genbank:NM_023016.3,HGNC:HGNC:26149 sosondowah ankyrin repeat domain family member C SOWAHD 10.6361069234545 8.66739775606975 12.6048160908392 1.45427917877798 0.540304250809136 0.579525591395133 1 0.308459 0.298711 0.638644 0.297199 GeneID:347454,Genbank:NM_001105576.2,HGNC:HGNC:32960 sosondowah ankyrin repeat domain family member D SOX11 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00693535 0 0 0 GeneID:6664,Genbank:NM_003108.3,HGNC:HGNC:11191,MIM:600898 SRY-box 11 SOX12 862.725487976478 736.381799687172 989.069176265784 1.34314723243562 0.425617458050753 0.00695793752470434 0.331661688677574 7.13916 7.50022 9.66264 10.476 GeneID:6666,Genbank:NM_006943.3,HGNC:HGNC:11198,MIM:601947 SRY-box 12 GO:0000976,GO:0001077,GO:0001105,GO:0003677,GO:0005654,GO:0006357,GO:0021510,GO:0032993,GO:0045165,GO:0045944,GO:0065004 transcription regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription coactivator activity|DNA binding|nucleoplasm|regulation of transcription from RNA polymerase II promoter|spinal cord development|protein-DNA complex|cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|protein-DNA complex assembly SOX13 910.97625174327 835.739798768968 986.212704717572 1.18004755328183 0.23884499814775 0.130202080930005 1 8.40722 8.8587 10.354 10.0964 GeneID:9580,Genbank:XM_005245623.3,HGNC:HGNC:11192,MIM:604748 SRY-box 13 GO:0000977,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0009653,GO:0043565,GO:0045586 RNA polymerase II regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|anatomical structure morphogenesis|sequence-specific DNA binding|regulation of gamma-delta T cell differentiation SOX15 10.6324328031444 13.0300140990011 8.23485150728773 0.631990989780974 -0.662024104666897 0.571297865180047 1 0.200461 0.57866 0.110032 0.377424 GeneID:6665,Genbank:NM_006942.1,HGNC:HGNC:11196,MIM:601297 SRY-box 15 GO:0000122,GO:0000981,GO:0003677,GO:0003682,GO:0003700,GO:0005634,GO:0005737,GO:0006325,GO:0006355,GO:0006357,GO:0008584,GO:0014718,GO:0030154,GO:0043403,GO:0044798,GO:0045843,GO:0045944,GO:0046982,GO:0048627,GO:0070318,GO:2000288 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|chromatin binding|DNA binding transcription factor activity|nucleus|cytoplasm|chromatin organization|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|male gonad development|positive regulation of satellite cell activation involved in skeletal muscle regeneration|cell differentiation|skeletal muscle tissue regeneration|nuclear transcription factor complex|negative regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|myoblast development|positive regulation of G0 to G1 transition|positive regulation of myoblast proliferation SOX18 52.2207596830324 59.3936751853559 45.0478441807088 0.75846197495143 -0.398851241276134 0.592590919047696 1 2.74507 2.97446 1.13666 3.66484 GeneID:54345,Genbank:NM_018419.2,HGNC:HGNC:11194,MIM:601618 SRY-box 18 GO:0000122,GO:0000790,GO:0000978,GO:0001077,GO:0001525,GO:0001570,GO:0001701,GO:0001942,GO:0001944,GO:0001946,GO:0001947,GO:0003151,GO:0005634,GO:0022405,GO:0035050,GO:0042789,GO:0043534,GO:0044212,GO:0044798,GO:0045892,GO:0045893,GO:0045944,GO:0046982,GO:0048469,GO:0048866,GO:0060214,GO:0060836,GO:0060956,GO:0061028,GO:0072091 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|angiogenesis|vasculogenesis|in utero embryonic development|hair follicle development|vasculature development|lymphangiogenesis|heart looping|outflow tract morphogenesis|nucleus|hair cycle process|embryonic heart tube development|mRNA transcription from RNA polymerase II promoter|blood vessel endothelial cell migration|transcription regulatory region DNA binding|nuclear transcription factor complex|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|cell maturation|stem cell fate specification|endocardium formation|lymphatic endothelial cell differentiation|endocardial cell differentiation|establishment of endothelial barrier|regulation of stem cell proliferation SOX2 6137.18220613772 5682.99151472614 6591.37289754931 1.1598421149265 0.213928429908625 0.102834023719927 1 109.497 105.892 127.069 122.741 GeneID:6657,Genbank:NM_003106.3,HGNC:HGNC:11195,MIM:184429 SRY-box 2 hsa04390,hsa04550 Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells SOX21 1086.78585834277 1083.71186015597 1089.85985652956 1.00567309134432 0.00816141235707742 0.987686803113836 1 24.033 26.849 25.1242 27.7287 GeneID:11166,Genbank:NM_007084.3,HGNC:HGNC:11197,MIM:604974 SRY-box 21 GO:0000978,GO:0000981,GO:0001077,GO:0001942,GO:0003677,GO:0003700,GO:0005634,GO:0006355,GO:0006357,GO:0048863 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|hair follicle development|DNA binding|DNA binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|stem cell differentiation SOX3 569.843866674314 601.316231847389 538.37150150124 0.895321750831891 -0.159521859536007 0.345103469713115 1 19.6812 18.712 15.9885 18.806 GeneID:6658,Genbank:NM_005634.2,HGNC:HGNC:11199,MIM:313430 SRY-box 3 GO:0000979,GO:0001106,GO:0003677,GO:0005654,GO:0006351,GO:0007417,GO:0007423,GO:0007530,GO:0021854,GO:0021983,GO:0045665,GO:0060324 RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II transcription corepressor activity|DNA binding|nucleoplasm|transcription, DNA-templated|central nervous system development|sensory organ development|sex determination|hypothalamus development|pituitary gland development|negative regulation of neuron differentiation|face development SOX30 1.72882185942616 1.51824048055703 1.93940323829528 1.27740187614003 0.353212474534228 1 1 0 0.0159767 0.0245687 0.00765468 GeneID:11063,Genbank:XM_005265803.5,HGNC:HGNC:30635,MIM:606698 SRY-box 30 GO:0000981,GO:0005634,GO:0006351,GO:0006355,GO:0006357,GO:0007283,GO:0031960,GO:0043565 RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|spermatogenesis|response to corticosteroid|sequence-specific DNA binding SOX4 3884.42815078067 3673.76480469705 4095.0914968643 1.11468526554247 0.15663641872099 0.238295158960952 1 42.7969 40.191 47.615 45.9627 GeneID:6659,Genbank:NM_003107.2,HGNC:HGNC:11200,MIM:184430 SRY-box 4 hsa05206 MicroRNAs in cancer SOX5 111.779330012441 102.384671387802 121.173988637079 1.18351689754523 0.243080304155056 0.404759636370021 1 0.165382 0.189286 0.238115 0.162079 GeneID:6660,Genbank:XM_024449159.1,HGNC:HGNC:11201,MIM:604975 SRY-box 5 GO:0003677,GO:0003700,GO:0005634,GO:0006366,GO:0032332,GO:0055059,GO:0061036,GO:0071560,GO:2000741 DNA binding|DNA binding transcription factor activity|nucleus|transcription from RNA polymerase II promoter|positive regulation of chondrocyte differentiation|asymmetric neuroblast division|positive regulation of cartilage development|cellular response to transforming growth factor beta stimulus|positive regulation of mesenchymal stem cell differentiation SOX6 7.14901198186282 4.60274771635603 9.69527624736962 2.1064105279803 1.07478663720066 0.354234028917401 1 0.0136543 0.0215358 0.0479101 0.0283763 GeneID:55553,Genbank:NM_033326.3,HGNC:HGNC:16421,MIM:607257 SRY-box 6 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0007275 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development SOX7 8.06548040019995 9.34957425676688 6.78138654363301 0.725315009795755 -0.463320390287373 0.71156888106151 1 0.160922 0.0782514 0.0410266 0.140762 GeneID:83595,Genbank:NM_031439.3,HGNC:HGNC:18196,MIM:612202 SRY-box 7 GO:0001706,GO:0003700,GO:0003705,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0008285,GO:0043280,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0060828 endoderm formation|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|negative regulation of cell proliferation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|sequence-specific DNA binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|regulation of canonical Wnt signaling pathway SOX8 4.91480682379712 4.01662376502878 5.81298988256547 1.44723285590673 0.533297066330251 0.774681546165532 1 0.0383938 0.0976784 0.0529702 0.148689 GeneID:30812,Genbank:NM_014587.4,HGNC:HGNC:11203,MIM:605923 SRY-box 8 GO:0000979,GO:0000981,GO:0001649,GO:0001701,GO:0001755,GO:0003677,GO:0005634,GO:0005737,GO:0006351,GO:0007165,GO:0007283,GO:0007422,GO:0008134,GO:0008584,GO:0010817,GO:0014015,GO:0033690,GO:0035914,GO:0043066,GO:0044798,GO:0045165,GO:0045444,GO:0045662,GO:0045892,GO:0045893,GO:0045944,GO:0046533,GO:0046982,GO:0048469,GO:0048484,GO:0048709,GO:0060009,GO:0060018,GO:0060041,GO:0060221,GO:0060612,GO:0061138,GO:0072034,GO:0072197,GO:0072289,GO:0090184,GO:0090190 RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|osteoblast differentiation|in utero embryonic development|neural crest cell migration|DNA binding|nucleus|cytoplasm|transcription, DNA-templated|signal transduction|spermatogenesis|peripheral nervous system development|transcription factor binding|male gonad development|regulation of hormone levels|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|skeletal muscle cell differentiation|negative regulation of apoptotic process|nuclear transcription factor complex|cell fate commitment|fat cell differentiation|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of photoreceptor cell differentiation|protein heterodimerization activity|cell maturation|enteric nervous system development|oligodendrocyte differentiation|Sertoli cell development|astrocyte fate commitment|retina development in camera-type eye|retinal rod cell differentiation|adipose tissue development|morphogenesis of a branching epithelium|renal vesicle induction|ureter morphogenesis|metanephric nephron tubule formation|positive regulation of kidney development|positive regulation of branching involved in ureteric bud morphogenesis SOX9 2890.67399515483 2576.35259659819 3204.99539371147 1.24400495411355 0.314992230855031 0.0206020285155096 0.586657016555258 32.1876 29.6626 41.8399 36.3207 GeneID:6662,Genbank:NM_000346.3,HGNC:HGNC:11204,MIM:608160 SRY-box 9 GO:0001046,GO:0001077,GO:0001158,GO:0001501,GO:0001502,GO:0001503,GO:0001658,GO:0001708,GO:0001837,GO:0001894,GO:0001934,GO:0001942,GO:0002053,GO:0002062,GO:0002683,GO:0003170,GO:0003179,GO:0003188,GO:0003203,GO:0003413,GO:0003415,GO:0003682,GO:0003700,GO:0003705,GO:0004672,GO:0005634,GO:0005654,GO:0006334,GO:0006338,GO:0006367,GO:0006461,GO:0007010,GO:0007165,GO:0007173,GO:0007219,GO:0007283,GO:0008013,GO:0008284,GO:0008584,GO:0010564,GO:0010634,GO:0014032,GO:0014036,GO:0014068,GO:0019100,GO:0019933,GO:0030155,GO:0030198,GO:0030279,GO:0030502,GO:0030850,GO:0030857,GO:0030858,GO:0030879,GO:0030903,GO:0030916,GO:0031018,GO:0032331,GO:0032332,GO:0032808,GO:0034236,GO:0034504,GO:0035019,GO:0035326,GO:0035622,GO:0042127,GO:0042981,GO:0043066,GO:0043234,GO:0043425,GO:0043491,GO:0044798,GO:0045662,GO:0045732,GO:0045892,GO:0045893,GO:0045944,GO:0046533,GO:0046982,GO:0048709,GO:0050679,GO:0050680,GO:0051216,GO:0060008,GO:0060009,GO:0060018,GO:0060041,GO:0060174,GO:0060221,GO:0060441,GO:0060487,GO:0060517,GO:0060532,GO:0060534,GO:0060729,GO:0060784,GO:0061036,GO:0061046,GO:0061138,GO:0061145,GO:0070168,GO:0070371,GO:0070384,GO:0071260,GO:0071300,GO:0071347,GO:0071364,GO:0071504,GO:0071560,GO:0071773,GO:0072034,GO:0072190,GO:0072193,GO:0072197,GO:0072289,GO:0090090,GO:0090103,GO:0090184,GO:0090190,GO:0097157,GO:0098609,GO:1901203,GO:1902894,GO:2000020,GO:2000138,GO:2000741,GO:2000794,GO:2001054 core promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|enhancer sequence-specific DNA binding|skeletal system development|cartilage condensation|ossification|branching involved in ureteric bud morphogenesis|cell fate specification|epithelial to mesenchymal transition|tissue homeostasis|positive regulation of protein phosphorylation|hair follicle development|positive regulation of mesenchymal cell proliferation|chondrocyte differentiation|negative regulation of immune system process|heart valve development|heart valve morphogenesis|heart valve formation|endocardial cushion morphogenesis|chondrocyte differentiation involved in endochondral bone morphogenesis|chondrocyte hypertrophy|chromatin binding|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|protein kinase activity|nucleus|nucleoplasm|nucleosome assembly|chromatin remodeling|transcription initiation from RNA polymerase II promoter|protein complex assembly|cytoskeleton organization|signal transduction|epidermal growth factor receptor signaling pathway|Notch signaling pathway|spermatogenesis|beta-catenin binding|positive regulation of cell proliferation|male gonad development|regulation of cell cycle process|positive regulation of epithelial cell migration|neural crest cell development|neural crest cell fate specification|positive regulation of phosphatidylinositol 3-kinase signaling|male germ-line sex determination|cAMP-mediated signaling|regulation of cell adhesion|extracellular matrix organization|negative regulation of ossification|negative regulation of bone mineralization|prostate gland development|negative regulation of epithelial cell differentiation|positive regulation of epithelial cell differentiation|mammary gland development|notochord development|otic vesicle formation|endocrine pancreas development|negative regulation of chondrocyte differentiation|positive regulation of chondrocyte differentiation|lacrimal gland development|protein kinase A catalytic subunit binding|protein localization to nucleus|somatic stem cell population maintenance|enhancer binding|intrahepatic bile duct development|regulation of cell proliferation|regulation of apoptotic process|negative regulation of apoptotic process|protein complex|bHLH transcription factor binding|protein kinase B signaling|nuclear transcription factor complex|negative regulation of myoblast differentiation|positive regulation of protein catabolic process|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|negative regulation of photoreceptor cell differentiation|protein heterodimerization activity|oligodendrocyte differentiation|positive regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|cartilage development|Sertoli cell differentiation|Sertoli cell development|astrocyte fate commitment|retina development in camera-type eye|limb bud formation|retinal rod cell differentiation|epithelial tube branching involved in lung morphogenesis|lung epithelial cell differentiation|epithelial cell proliferation involved in prostatic bud elongation|bronchus cartilage development|trachea cartilage development|intestinal epithelial structure maintenance|regulation of cell proliferation involved in tissue homeostasis|positive regulation of cartilage development|regulation of branching involved in lung morphogenesis|morphogenesis of a branching epithelium|lung smooth muscle development|negative regulation of biomineral tissue development|ERK1 and ERK2 cascade|Harderian gland development|cellular response to mechanical stimulus|cellular response to retinoic acid|cellular response to interleukin-1|cellular response to epidermal growth factor stimulus|cellular response to heparin|cellular response to transforming growth factor beta stimulus|cellular response to BMP stimulus|renal vesicle induction|ureter urothelium development|ureter smooth muscle cell differentiation|ureter morphogenesis|metanephric nephron tubule formation|negative regulation of canonical Wnt signaling pathway|cochlea morphogenesis|positive regulation of kidney development|positive regulation of branching involved in ureteric bud morphogenesis|pre-mRNA intronic binding|cell-cell adhesion|positive regulation of extracellular matrix assembly|negative regulation of pri-miRNA transcription from RNA polymerase II promoter|positive regulation of male gonad development|positive regulation of cell proliferation involved in heart morphogenesis|positive regulation of mesenchymal stem cell differentiation|regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell apoptotic process hsa04024 cAMP signaling pathway SP1 1843.46306240007 1868.43315584413 1818.49296895602 0.97327162241159 -0.0390856037356023 0.806288299991663 1 9.85896 9.33482 10.5589 8.24635 GeneID:6667,Genbank:NM_138473.2,HGNC:HGNC:11205,MIM:189906 Sp1 transcription factor GO:0000790,GO:0000977,GO:0000978,GO:0000982,GO:0001046,GO:0001077,GO:0001103,GO:0003677,GO:0003690,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006355,GO:0008022,GO:0008134,GO:0010628,GO:0016032,GO:0017053,GO:0032869,GO:0032993,GO:0035035,GO:0042795,GO:0042803,GO:0042826,GO:0043425,GO:0043536,GO:0043565,GO:0043923,GO:0044212,GO:0045540,GO:0045766,GO:0045893,GO:0045944,GO:0046872,GO:0048511,GO:0070491,GO:0071837,GO:0100057,GO:1904828,GO:1905564 nuclear chromatin|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|core promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II repressing transcription factor binding|DNA binding|double-stranded DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|protein C-terminus binding|transcription factor binding|positive regulation of gene expression|viral process|transcriptional repressor complex|cellular response to insulin stimulus|protein-DNA complex|histone acetyltransferase binding|snRNA transcription from RNA polymerase II promoter|protein homodimerization activity|histone deacetylase binding|bHLH transcription factor binding|positive regulation of blood vessel endothelial cell migration|sequence-specific DNA binding|positive regulation by host of viral transcription|transcription regulatory region DNA binding|regulation of cholesterol biosynthetic process|positive regulation of angiogenesis|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|rhythmic process|repressing transcription factor binding|HMG box domain binding|regulation of phenotypic switching by transcription from RNA polymerase II promoter|positive regulation of hydrogen sulfide biosynthetic process|positive regulation of vascular endothelial cell proliferation hsa01522,hsa04137,hsa04350,hsa04915,hsa04927,hsa04928,hsa04934,hsa05016,hsa05163,hsa05200,hsa05202,hsa05224,hsa05231 Endocrine resistance|Mitophagy - animal|TGF-beta signaling pathway|Estrogen signaling pathway|Cortisol synthesis and secretion|Parathyroid hormone synthesis, secretion and action|Cushing syndrome|Huntington disease|Human cytomegalovirus infection|Pathways in cancer|Transcriptional misregulation in cancer|Breast cancer|Choline metabolism in cancer SP100 629.984869505245 497.86517376141 762.10456524908 1.53074487916341 0.614233856818452 0.36993759363979 1 1.47778 1.65179 3.42209 1.44332 GeneID:6672,Genbank:NM_001080391.1,HGNC:HGNC:11206,MIM:604585 SP100 nuclear antigen GO:0000122,GO:0000723,GO:0000784,GO:0003677,GO:0003713,GO:0003714,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006351,GO:0006978,GO:0008134,GO:0010596,GO:0016032,GO:0016604,GO:0016605,GO:0019900,GO:0019904,GO:0032526,GO:0032897,GO:0034097,GO:0034340,GO:0034341,GO:0034399,GO:0042802,GO:0042803,GO:0043392,GO:0043433,GO:0045185,GO:0045765,GO:0045892,GO:0045893,GO:0046826,GO:0048384,GO:0051091,GO:0051271,GO:0060333,GO:0060337,GO:0070087,GO:1902041,GO:1902044 negative regulation of transcription from RNA polymerase II promoter|telomere maintenance|nuclear chromosome, telomeric region|DNA binding|transcription coactivator activity|transcription corepressor activity|nucleus|nucleoplasm|nucleolus|cytoplasm|transcription, DNA-templated|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|transcription factor binding|negative regulation of endothelial cell migration|viral process|nuclear body|PML body|kinase binding|protein domain specific binding|response to retinoic acid|negative regulation of viral transcription|response to cytokine|response to type I interferon|response to interferon-gamma|nuclear periphery|identical protein binding|protein homodimerization activity|negative regulation of DNA binding|negative regulation of DNA binding transcription factor activity|maintenance of protein location|regulation of angiogenesis|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|negative regulation of protein export from nucleus|retinoic acid receptor signaling pathway|positive regulation of DNA binding transcription factor activity|negative regulation of cellular component movement|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway|chromo shadow domain binding|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of Fas signaling pathway hsa05168,hsa05203 Herpes simplex infection|Viral carcinogenesis SP110 458.499380079923 282.804331544701 634.194428615145 2.24252020876456 1.16512098623843 0.281990120424081 1 1.16724 1.21157 4.37597 1.26889 GeneID:3431,Genbank:XM_024452850.1,HGNC:HGNC:5401,MIM:604457 SP110 nuclear body protein SP140 11.0776216044199 14.8844385023527 7.27080470648717 0.488483640504001 -1.03361784826987 0.243522597071867 1 0.0593599 0.0474369 0.0437387 0.00813151 GeneID:11262,Genbank:XM_011510517.3,HGNC:HGNC:17133,MIM:608602 SP140 nuclear body protein GO:0001650,GO:0003677,GO:0003700,GO:0005634,GO:0005635,GO:0005654,GO:0005739,GO:0006952,GO:0016605,GO:0046872 fibrillar center|DNA binding|DNA binding transcription factor activity|nucleus|nuclear envelope|nucleoplasm|mitochondrion|defense response|PML body|metal ion binding SP140L 317.262969048075 305.414242618786 329.111695477363 1.07759118453476 0.107809953685674 0.655159531388816 1 1.40102 1.26975 1.72618 1.20961 GeneID:93349,Genbank:XM_017005297.1,HGNC:HGNC:25105,MIM:617747 SP140 nuclear body protein like GO:0003677,GO:0016604,GO:0046872 DNA binding|nuclear body|metal ion binding SP2 756.643280628904 773.760479404023 739.526081853784 0.955755820487746 -0.0652860138863051 0.683839426462854 1 3.25765 3.1233 3.03168 3.0215 GeneID:6668,Genbank:XM_011525139.2,HGNC:HGNC:11207,MIM:601801 Sp2 transcription factor GO:0000122,GO:0000978,GO:0001078,GO:0005634,GO:0006351,GO:0006357,GO:0006955,GO:0035264,GO:0042826,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|immune response|multicellular organism growth|histone deacetylase binding|metal ion binding SP3 839.226598357217 868.023625365796 810.429571348637 0.933649209152702 -0.0990474927863724 0.747225339288706 1 6.26107 5.30239 6.678 4.37375 GeneID:6670,Genbank:NM_001172712.1,HGNC:HGNC:11208,MIM:601804 Sp3 transcription factor GO:0000977,GO:0000978,GO:0000981,GO:0001078,GO:0001503,GO:0001779,GO:0001829,GO:0001889,GO:0001892,GO:0003682,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0016605,GO:0016925,GO:0017053,GO:0030183,GO:0030217,GO:0030219,GO:0030224,GO:0030324,GO:0030851,GO:0043353,GO:0045892,GO:0045893,GO:0045944,GO:0046872,GO:0048596,GO:0048706,GO:0060136,GO:0060216 RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|ossification|natural killer cell differentiation|trophectodermal cell differentiation|liver development|embryonic placenta development|chromatin binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|PML body|protein sumoylation|transcriptional repressor complex|B cell differentiation|T cell differentiation|megakaryocyte differentiation|monocyte differentiation|lung development|granulocyte differentiation|enucleate erythrocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|embryonic camera-type eye morphogenesis|embryonic skeletal system development|embryonic process involved in female pregnancy|definitive hemopoiesis SP4 122.290153208272 115.154936803163 129.425369613381 1.12392376051243 0.168544176073907 0.663459161959312 1 0.459242 0.47184 0.638723 0.382222 GeneID:6671,Genbank:NM_003112.4,HGNC:HGNC:11209,MIM:600540 Sp4 transcription factor GO:0000981,GO:0003713,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006357,GO:0043565,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcription coactivator activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|sequence-specific DNA binding|metal ion binding SP6 3.02016670492339 3.13253351048394 2.90779989936283 0.928258194088275 -0.107401949533076 1 1 0.0499738 0.0219946 0.0232356 0.0217831 GeneID:80320,Genbank:XM_006722115.3,HGNC:HGNC:14530,MIM:608613 Sp6 transcription factor GO:0000981,GO:0003677,GO:0005634,GO:0005829,GO:0006351,GO:0006357,GO:0008284,GO:0042481,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|positive regulation of cell proliferation|regulation of odontogenesis|metal ion binding SP8 49.4009853122097 60.0278254113681 38.7741452130513 0.645936196211236 -0.630536428351572 0.122863493210027 1 1.05818 0.981816 0.743021 0.463061 GeneID:221833,Genbank:NM_182700.5,HGNC:HGNC:19196,MIM:608306 Sp8 transcription factor GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0006357,GO:0009953,GO:0009954,GO:0030326,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|dorsal/ventral pattern formation|proximal/distal pattern formation|embryonic limb morphogenesis|metal ion binding SP9 17.9884138882077 11.2618335899114 24.7149941865039 2.19457994909854 1.13394482889748 0.0965731778196709 1 0.292596 0.525516 0.919044 0.854208 GeneID:100131390,Genbank:NM_001145250.1,HGNC:HGNC:30690 Sp9 transcription factor GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0006357,GO:0030326,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|embryonic limb morphogenesis|metal ion binding SPA17 111.011000314765 105.238855905284 116.783144724246 1.10969606919094 0.15016459593364 0.69011128309611 1 1.32624 2.30352 1.70552 1.8532 GeneID:53340,Genbank:NM_017425.3,HGNC:HGNC:11210,MIM:608621 sperm autoantigenic protein 17 SPAAR 66.0925439353 50.2842323020138 81.9008555685862 1.62875819753355 0.703772439890101 0.0488657221366163 0.809341681220317 1.47051 1.29707 2.37744 2.25298 GeneID:158376,Genbank:NM_001348107.1,HGNC:HGNC:27244,MIM:617627 small regulatory polypeptide of amino acid response GO:0031902,GO:0043416,GO:0071230,GO:1904262,GO:1905103 late endosome membrane|regulation of skeletal muscle tissue regeneration|cellular response to amino acid stimulus|negative regulation of TORC1 signaling|integral component of lysosomal membrane SPACA6 347.987746434127 333.49239135441 362.483101513844 1.0869306494271 0.120259893521251 0.540773146490114 1 0.98808 0.980152 1.07812 1.2727 GeneID:147650,Genbank:XM_017026300.2,HGNC:HGNC:27113 sperm acrosome associated 6 GO:0007342,GO:0016021 fusion of sperm to egg plasma membrane involved in single fertilization|integral component of membrane SPACA9 51.2333289630126 54.9830325677397 47.4836253582854 0.863605063976511 -0.211556391878518 0.617949909617433 1 0.693069 0.572582 0.46135 0.720964 GeneID:11092,Genbank:XM_024447397.1,HGNC:HGNC:1367 sperm acrosome associated 9 GO:0001669,GO:0005881,GO:0048306 acrosomal vesicle|cytoplasmic microtubule|calcium-dependent protein binding SPAG1 301.450986336295 310.151260504089 292.7507121685 0.943896573861066 -0.0832993079192157 0.736419414935676 1 2.35245 2.05995 2.49726 1.83652 GeneID:6674,Genbank:XM_017013754.1,HGNC:HGNC:11212,MIM:603395 sperm associated antigen 1 GO:0005525,GO:0005737,GO:0005829,GO:0007338,GO:0016787,GO:0070286 GTP binding|cytoplasm|cytosol|single fertilization|hydrolase activity|axonemal dynein complex assembly SPAG16 188.43657488375 192.219591423453 184.653558344047 0.960638595559502 -0.0579343220150143 0.823562320952789 1 0.354865 0.405592 0.393056 0.360839 GeneID:79582,Genbank:XM_017004896.1,HGNC:HGNC:23225,MIM:612173 sperm associated antigen 16 GO:0005634,GO:0005930,GO:0007288,GO:0031514,GO:0035082,GO:0051012,GO:0060271,GO:0060294,GO:0097231,GO:1990716 nucleus|axoneme|sperm axoneme assembly|motile cilium|axoneme assembly|microtubule sliding|cilium assembly|cilium movement involved in cell motility|cell motility in response to calcium ion|axonemal central apparatus SPAG17 251.009653502944 279.536510864416 222.482796141472 0.79589888080625 -0.329342947317287 0.356151271755481 1 0.68502 0.547146 0.608295 0.478449 GeneID:200162,Genbank:NM_206996.3,HGNC:HGNC:26620,MIM:616554 sperm associated antigen 17 GO:0003351,GO:0005874,GO:0031514,GO:1904158,GO:1990716 epithelial cilium movement|microtubule|motile cilium|axonemal central apparatus assembly|axonemal central apparatus SPAG4 20.5310169395992 15.8645813062674 25.1974525729309 1.58828349053098 0.667468440113708 0.298531377944112 1 0.107985 0.436966 0.466103 0.466008 GeneID:6676,Genbank:XM_011529009.2,HGNC:HGNC:11214,MIM:603038 sperm associated antigen 4 GO:0005198,GO:0005635,GO:0005637,GO:0005737,GO:0005856,GO:0006998,GO:0007283,GO:0016021,GO:0030154,GO:0031514,GO:0043495,GO:0090286 structural molecule activity|nuclear envelope|nuclear inner membrane|cytoplasm|cytoskeleton|nuclear envelope organization|spermatogenesis|integral component of membrane|cell differentiation|motile cilium|protein membrane anchor|cytoskeletal anchoring at nuclear membrane SPAG5 4850.36624705069 4877.7321954279 4823.00029867349 0.988779232938267 -0.0162796518590713 0.913622992507983 1 37.9143 36.1288 37.385 36.0051 GeneID:10615,Genbank:NM_006461.3,HGNC:HGNC:13452,MIM:615562 sperm associated antigen 5 GO:0000070,GO:0000776,GO:0000777,GO:0005737,GO:0005876,GO:0007051,GO:0007059,GO:0008017,GO:0030496,GO:0032388,GO:0034451,GO:0035371,GO:0051294,GO:0051301,GO:0051988,GO:0071539,GO:0072686,GO:0090235,GO:0097431,GO:1905832 mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|cytoplasm|spindle microtubule|spindle organization|chromosome segregation|microtubule binding|midbody|positive regulation of intracellular transport|centriolar satellite|microtubule plus-end|establishment of spindle orientation|cell division|regulation of attachment of spindle microtubules to kinetochore|protein localization to centrosome|mitotic spindle|regulation of metaphase plate congression|mitotic spindle pole|positive regulation of spindle assembly SPAG6 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0146396 0 0.0138193 GeneID:9576,Genbank:NM_001253855.1,HGNC:HGNC:11215,MIM:605730 sperm associated antigen 6 GO:0005634,GO:0005874,GO:0005930,GO:0007286,GO:0015630,GO:0030030,GO:0031514 nucleus|microtubule|axoneme|spermatid development|microtubule cytoskeleton|cell projection organization|motile cilium SPAG7 1346.24626243795 1441.27456813523 1251.21795674068 0.868132959814549 -0.204012077822325 0.157539127084318 1 18.3014 20.5545 16.5508 18.4834 GeneID:9552,Genbank:NM_004890.2,HGNC:HGNC:11216,MIM:610056 sperm associated antigen 7 GO:0003676,GO:0005634 nucleic acid binding|nucleus SPAG8 13.4645939210059 12.8761266198383 14.0530612221736 1.09140439800599 0.126185762428336 0.915321793729968 1 0.111944 0.0581994 0.120427 0.15456 GeneID:26206,Genbank:NM_172312.1,HGNC:HGNC:14105,MIM:605731 sperm associated antigen 8 GO:0001669,GO:0005634,GO:0005737,GO:0005819,GO:0007049,GO:0007283,GO:0007338,GO:0008017,GO:0016020,GO:0030154,GO:0045944 acrosomal vesicle|nucleus|cytoplasm|spindle|cell cycle|spermatogenesis|single fertilization|microtubule binding|membrane|cell differentiation|positive regulation of transcription from RNA polymerase II promoter SPAG9 1782.32362483859 1785.36216588565 1779.28508379153 0.996596162834498 -0.00491907562238707 0.999166265182739 1 6.53232 5.77163 7.17848 5.09227 GeneID:9043,Genbank:NM_003971.5,HGNC:HGNC:14524,MIM:605430 sperm associated antigen 9 GO:0001669,GO:0005078,GO:0005737,GO:0005815,GO:0005829,GO:0007257,GO:0007283,GO:0008432,GO:0016021,GO:0019894,GO:0030159,GO:0030335,GO:0042147,GO:0045666,GO:0048273,GO:0048471,GO:0051146,GO:0051149,GO:0051260,GO:0070062,GO:0090074 acrosomal vesicle|MAP-kinase scaffold activity|cytoplasm|microtubule organizing center|cytosol|activation of JUN kinase activity|spermatogenesis|JUN kinase binding|integral component of membrane|kinesin binding|receptor signaling complex scaffold activity|positive regulation of cell migration|retrograde transport, endosome to Golgi|positive regulation of neuron differentiation|mitogen-activated protein kinase p38 binding|perinuclear region of cytoplasm|striated muscle cell differentiation|positive regulation of muscle cell differentiation|protein homooligomerization|extracellular exosome|negative regulation of protein homodimerization activity SPANXA1 0.97133319677934 0.490071401957362 1.45259499160132 2.96404765876891 1.56756864484914 0.837512515494886 1 0 0.120239 0 0.113812 GeneID:30014,Genbank:NM_013453.3,HGNC:HGNC:11218,MIM:300305 sperm protein associated with the nucleus, X-linked, family member A1 GO:0005634,GO:0005737,GO:0007283 nucleus|cytoplasm|spermatogenesis SPANXB1 14.014098214749 10.5796570892143 17.4485393402838 1.64925377005576 0.72181340279764 0.377930550382943 1 0.507964 1.09818 1.50233 1.14148 GeneID:728695,Genbank:NM_032461.3,HGNC:HGNC:14329,MIM:300669 SPANX family member B1 GO:0005634,GO:0005737,GO:0007286 nucleus|cytoplasm|spermatid development SPANXC 0.99578132014851 0.538097676642304 1.45346496365472 2.70111733751434 1.43355631240266 0.835241087836065 1 0 0 0.117626 0.219856 GeneID:64663,Genbank:NM_022661.3,HGNC:HGNC:14331,MIM:300330 SPANX family member C GO:0005634,GO:0005737 nucleus|cytoplasm SPANXD 4.44779272150742 6.95705217677295 1.93853326624189 0.278642910385801 -1.84351064802568 0.331216374161371 1 0.128308 0.522731 0.180691 0.112071 GeneID:64648,Genbank:NM_032417.3,HGNC:HGNC:14332,MIM:300671 SPANX family member D GO:0005634,GO:0005737 nucleus|cytoplasm SPANXN1 0.972638154859436 0.490071401957362 1.45520490776151 2.96937324224464 1.5701584476161 0.837389832160054 1 0 0.0495665 0 0 GeneID:494118,Genbank:NM_001009614.2,HGNC:HGNC:33174,MIM:300664 SPANX family member N1 SPARC 47436.2881754731 45219.4528205224 49653.1235304238 1.09804786288544 0.134940941449216 0.291508743457194 1 440.124 443.324 496.72 483.898 GeneID:6678,Genbank:NM_001309443.1,HGNC:HGNC:11219,MIM:182120 secreted protein acidic and cysteine rich SPARCL1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00872669 0 GeneID:8404,Genbank:NM_004684.5,HGNC:HGNC:11220,MIM:606041 SPARC like 1 GO:0005509,GO:0005518,GO:0005576,GO:0005578,GO:0005615,GO:0005788,GO:0007165,GO:0043687,GO:0044267,GO:0048856,GO:0050840,GO:0070062 calcium ion binding|collagen binding|extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|signal transduction|post-translational protein modification|cellular protein metabolic process|anatomical structure development|extracellular matrix binding|extracellular exosome SPART 959.195152510492 1062.47305973583 855.917245285157 0.805589598194585 -0.311883039559014 0.045368872469977 0.792169711191323 7.47393 7.02833 6.62587 5.34249 GeneID:23111,Genbank:NM_001142294.1,HGNC:HGNC:18514,MIM:607111 spartin GO:0005737,GO:0005741,GO:0005811,GO:0005829,GO:0005886,GO:0009838,GO:0030496,GO:0030514,GO:0031625,GO:0034389,GO:0045202,GO:0048698,GO:0050905,GO:0051301,GO:0051881,GO:0060612 cytoplasm|mitochondrial outer membrane|lipid droplet|cytosol|plasma membrane|abscission|midbody|negative regulation of BMP signaling pathway|ubiquitin protein ligase binding|lipid particle organization|synapse|negative regulation of collateral sprouting in absence of injury|neuromuscular process|cell division|regulation of mitochondrial membrane potential|adipose tissue development hsa04144 Endocytosis SPAST 174.063636191723 200.291056573087 147.836215810359 0.738106924691431 -0.438098269728736 0.090391009214151 0.979717040875575 1.85534 1.62883 1.57038 0.986852 GeneID:6683,Genbank:XM_011533067.2,HGNC:HGNC:11233,MIM:604277 spastin SPATA1 6.03739687413498 5.77499561901052 6.29979812925943 1.09087496248851 0.125485747549991 0.972445158215975 1 0.0359277 0.0238139 0 0 GeneID:100505741,Genbank:NM_001310156.1,HGNC:HGNC:14682 spermatogenesis associated 1 SPATA12 15.105062112214 11.3098598645963 18.9002643598317 1.67113161313306 0.740825360052061 0.323784779920081 1 0.167957 0.139148 0.258995 0.215144 GeneID:353324,Genbank:NM_181727.1,HGNC:HGNC:23221,MIM:609869 spermatogenesis associated 12 SPATA13 418.742261965231 416.774086720983 420.710437209479 1.00944480622456 0.0135620300720616 0.954879804162111 1 1.61174 1.67578 1.90367 1.40323 GeneID:221178,Genbank:NM_001286792.1,HGNC:HGNC:23222,MIM:613324 spermatogenesis associated 13 GO:0005085,GO:0005654,GO:0005737,GO:0005829,GO:0016477,GO:0030027,GO:0030032,GO:0030175,GO:0030334,GO:0030676,GO:0032587,GO:0035023,GO:0042802,GO:0046847 guanyl-nucleotide exchange factor activity|nucleoplasm|cytoplasm|cytosol|cell migration|lamellipodium|lamellipodium assembly|filopodium|regulation of cell migration|Rac guanyl-nucleotide exchange factor activity|ruffle membrane|regulation of Rho protein signal transduction|identical protein binding|filopodium assembly hsa04810 Regulation of actin cytoskeleton SPATA17 5.6247041977857 4.94874029425856 6.30066810131283 1.27318625077633 0.348443482410141 0.883375687973781 1 0.0151367 0.0582665 0.0436989 0.05423 GeneID:128153,Genbank:NM_138796.3,HGNC:HGNC:25184,MIM:611032 spermatogenesis associated 17 GO:0005516,GO:0005737 calmodulin binding|cytoplasm SPATA18 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.0102753 0 GeneID:132671,Genbank:NM_145263.3,HGNC:HGNC:29579,MIM:612814 spermatogenesis associated 18 GO:0005737,GO:0005741,GO:0006974,GO:0035694,GO:0035695,GO:0043231 cytoplasm|mitochondrial outer membrane|cellular response to DNA damage stimulus|mitochondrial protein catabolic process|mitophagy by induced vacuole formation|intracellular membrane-bounded organelle SPATA2 291.065163458833 295.210004072798 286.920322844867 0.971919375652708 -0.0410914530422301 0.831508340030035 1 2.75627 3.02174 3.21483 2.5487 GeneID:9825,Genbank:NM_006038.3,HGNC:HGNC:14681,MIM:607662 spermatogenesis associated 2 GO:0001650,GO:0005634,GO:0005737,GO:0007275,GO:0007283,GO:0030154 fibrillar center|nucleus|cytoplasm|multicellular organism development|spermatogenesis|cell differentiation hsa04217 Necroptosis SPATA20 465.622613113504 387.034635681602 544.210590545407 1.4061030728865 0.491702353508472 0.00630347812719569 0.316479538626295 4.91887 5.78194 7.68875 8.34613 GeneID:64847,Genbank:NM_001258373.1,HGNC:HGNC:26125,MIM:613939 spermatogenesis associated 20 GO:0003824,GO:0005576,GO:0007275,GO:0007283,GO:0030154 catalytic activity|extracellular region|multicellular organism development|spermatogenesis|cell differentiation SPATA21 334.479360892568 373.88793472216 295.070787062975 0.789195798153383 -0.341544820021296 0.394110812655522 1 1.88354 1.51099 1.05036 1.68587 GeneID:374955,Genbank:XM_011541407.3,HGNC:HGNC:28026 spermatogenesis associated 21 GO:0005509 calcium ion binding SPATA24 130.995268170431 133.095473576845 128.895062764017 0.968440618602986 -0.0462645043690125 0.861477371925777 1 0.681998 0.82986 0.814401 0.863516 GeneID:202051,Genbank:XM_005271916.4,HGNC:HGNC:27322 spermatogenesis associated 24 GO:0003677,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006351,GO:0006355,GO:0007275,GO:0007283,GO:0030154,GO:0042803 DNA binding|nucleus|nucleoplasm|nucleolus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|spermatogenesis|cell differentiation|protein homodimerization activity SPATA25 9.98217545923285 9.30154798208194 10.6628029363838 1.14634714102686 0.197043992437241 0.874991458910065 1 0.153639 0.126749 0.192581 0.0800963 GeneID:128497,Genbank:XM_024451826.1,HGNC:HGNC:16158 spermatogenesis associated 25 GO:0007283,GO:0016021,GO:0030154 spermatogenesis|integral component of membrane|cell differentiation SPATA2L 191.579932940248 181.073427693127 202.08643818737 1.11604690297162 0.158397659122885 0.511170013358154 1 3.85892 4.09608 4.53197 4.37343 GeneID:124044,Genbank:NM_152339.3,HGNC:HGNC:28393 spermatogenesis associated 2 like hsa04217 Necroptosis SPATA31E1 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0 0.00660324 0 0.00652439 GeneID:286234,Genbank:NM_178828.4,HGNC:HGNC:26672 SPATA31 subfamily E member 1 GO:0007283,GO:0016021,GO:0030154 spermatogenesis|integral component of membrane|cell differentiation SPATA32 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:124783,Genbank:NM_152343.2,HGNC:HGNC:26349 spermatogenesis associated 32 GO:0003779,GO:0007283,GO:0048471 actin binding|spermatogenesis|perinuclear region of cytoplasm SPATA33 217.614408017047 212.302710248597 222.926105785496 1.05003890682536 0.070442784695289 0.760987039051321 1 2.39802 2.30139 2.67783 2.47913 GeneID:124045,Genbank:NM_153025.2,HGNC:HGNC:26463,MIM:615409 spermatogenesis associated 33 GO:0005634,GO:0005829 nucleus|cytosol SPATA4 2.19237857435595 1.96028560782945 2.42447154088245 1.23679505231229 0.306606453014791 1 1 0 0.144686 0.14569 0.0337992 GeneID:132851,Genbank:NM_144644.3,HGNC:HGNC:17333,MIM:609879 spermatogenesis associated 4 GO:0005737 cytoplasm SPATA45 2.48750711367797 3.03648096111406 1.93853326624189 0.638414431398462 -0.647434830746163 0.834072962860468 1 0.100251 0.27785 0 0.0867405 GeneID:149643,Genbank:NM_001024601.2,HGNC:HGNC:33709 spermatogenesis associated 45 SPATA46 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0262793 0 0 GeneID:284680,Genbank:NM_182581.3,HGNC:HGNC:27648,MIM:617257 spermatogenesis associated 46 GO:0007283,GO:0007342,GO:0030154,GO:0031965 spermatogenesis|fusion of sperm to egg plasma membrane involved in single fertilization|cell differentiation|nuclear membrane SPATA48 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0.0178453 0 GeneID:100130988,Genbank:XM_011515052.1,HGNC:HGNC:22564 spermatogenesis associated 48 SPATA5 269.63851097701 283.86090958777 255.416112366249 0.899793186519311 -0.15233465241141 0.483868386806155 1 0.404161 0.377263 0.400348 0.328985 GeneID:166378,Genbank:NM_145207.2,HGNC:HGNC:18119,MIM:613940 spermatogenesis associated 5 GO:0005524,GO:0005737,GO:0005739,GO:0007283,GO:0007420,GO:0030154 ATP binding|cytoplasm|mitochondrion|spermatogenesis|brain development|cell differentiation hsa03008 Ribosome biogenesis in eukaryotes SPATA5L1 305.42827754774 332.185873282809 278.670681812672 0.838899857657171 -0.253429493381105 0.193525738627021 1 4.85864 5.77027 4.6376 4.19121 GeneID:79029,Genbank:NM_024063.2,HGNC:HGNC:28762 spermatogenesis associated 5 like 1 GO:0005524,GO:0005737 ATP binding|cytoplasm SPATA6 163.651485681284 159.126075809524 168.176895553044 1.05687829412921 0.0798092513037062 0.752659915868257 1 0.419239 0.445959 0.491048 0.410263 GeneID:54558,Genbank:XM_006710699.3,HGNC:HGNC:18309,MIM:613947 spermatogenesis associated 6 GO:0005576,GO:0007275,GO:0007283,GO:0030154,GO:0032027,GO:0044458,GO:0097224 extracellular region|multicellular organism development|spermatogenesis|cell differentiation|myosin light chain binding|motile cilium assembly|sperm connecting piece SPATA6L 27.5528110176356 28.9328130248455 26.1728090104257 0.904606440720101 -0.144637827016789 0.835374107731249 1 0.125886 0.0923503 0.100169 0.0810034 GeneID:55064,Genbank:XM_017014882.2,HGNC:HGNC:25472 spermatogenesis associated 6 like SPATA7 53.5087314866648 58.557611205496 48.4598517678336 0.827558549097461 -0.273066709850351 0.501262124910879 1 0.498162 0.503841 0.532083 0.531384 GeneID:55812,Genbank:XM_011536953.1,HGNC:HGNC:20423,MIM:609868 spermatogenesis associated 7 GO:0005654,GO:0005739,GO:0005829,GO:0005930,GO:0007601,GO:0015630,GO:0032391,GO:0036064,GO:0045494,GO:0050896,GO:1903546,GO:1903621 nucleoplasm|mitochondrion|cytosol|axoneme|visual perception|microtubule cytoskeleton|photoreceptor connecting cilium|ciliary basal body|photoreceptor cell maintenance|response to stimulus|protein localization to photoreceptor outer segment|protein localization to photoreceptor connecting cilium SPATA9 8.67890314498674 14.9324647770376 2.42534151293585 0.162420708781139 -2.62219250576862 0.015364029249891 0.513716685733308 0.0438704 0.0210356 0.0105673 0 GeneID:83890,Genbank:XM_017009948.1,HGNC:HGNC:22988,MIM:608039 spermatogenesis associated 9 GO:0007275,GO:0007283,GO:0016021,GO:0030154 multicellular organism development|spermatogenesis|integral component of membrane|cell differentiation SPATC1L 336.007327690736 321.635642158919 350.379013222553 1.08936624955711 0.123489075805907 0.649035980008019 1 1.71964 2.59365 2.35407 2.61819 GeneID:84221,Genbank:XM_017028480.2,HGNC:HGNC:1298,MIM:612412 spermatogenesis and centriole associated 1 like GO:0005813 centrosome SPATS1 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0 0 0 0.0340877 GeneID:221409,Genbank:NM_145026.3,HGNC:HGNC:22957 spermatogenesis associated serine rich 1 SPATS2 632.129626349761 643.403520485074 620.855732214447 0.964955447782399 -0.0514657605348026 0.766731811361441 1 5.85068 5.7685 6.16581 5.00683 GeneID:65244,Genbank:NM_001293285.1,HGNC:HGNC:18650,MIM:611667 spermatogenesis associated serine rich 2 GO:0003723,GO:0005829 RNA binding|cytosol SPATS2L 2038.78104157856 1797.45025480032 2280.11182835681 1.26852569202818 0.343152739257029 0.289098796251717 1 8.826 7.82512 13.3673 8.27123 GeneID:26010,Genbank:NM_001282735.1,HGNC:HGNC:24574,MIM:613817 spermatogenesis associated serine rich 2 like GO:0003723,GO:0005634,GO:0005730,GO:0005829,GO:0043234 RNA binding|nucleus|nucleolus|cytosol|protein complex SPC24 1419.59369109853 1431.52116637077 1407.66621582629 0.983335942838373 -0.0242437177229647 0.90723907304279 1 13.4709 14.3865 12.556 15.793 GeneID:147841,Genbank:NM_001317031.1,HGNC:HGNC:26913,MIM:609394 SPC24, NDC80 kinetochore complex component GO:0000777,GO:0005634,GO:0005730,GO:0005829,GO:0007062,GO:0031262,GO:0051301 condensed chromosome kinetochore|nucleus|nucleolus|cytosol|sister chromatid cohesion|Ndc80 complex|cell division SPC25 638.067996940356 635.927987941875 640.208005938837 1.00673035009957 0.00967731326646174 0.960330776318526 1 13.6397 14.8752 15.9278 14.0516 GeneID:57405,Genbank:XM_011511516.2,HGNC:HGNC:24031,MIM:609395 SPC25, NDC80 kinetochore complex component GO:0000777,GO:0005634,GO:0005829,GO:0007052,GO:0007059,GO:0007062,GO:0031262,GO:0051301 condensed chromosome kinetochore|nucleus|cytosol|mitotic spindle organization|chromosome segregation|sister chromatid cohesion|Ndc80 complex|cell division SPCS1 2567.42899688648 2628.44322702887 2506.41476674408 0.953573864928889 -0.0685833992028288 0.628788525918163 1 144.063 136.719 132.26 138.584 GeneID:28972,Genbank:NM_014041.3,HGNC:HGNC:23401,MIM:610358 signal peptidase complex subunit 1 GO:0005787,GO:0006465,GO:0008233,GO:0016021,GO:0031090 signal peptidase complex|signal peptide processing|peptidase activity|integral component of membrane|organelle membrane hsa03060 Protein export SPCS2 1199.60783240669 1177.45550875047 1221.76015606292 1.03762744917595 0.053288549954974 0.708181576086647 1 20.0362 19.1751 21.4032 19.662 GeneID:9789,Genbank:NM_014752.2,HGNC:HGNC:28962 signal peptidase complex subunit 2 GO:0005787,GO:0005789,GO:0006465,GO:0008233,GO:0016021,GO:0031090,GO:0045047 signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|peptidase activity|integral component of membrane|organelle membrane|protein targeting to ER hsa03060 Protein export SPCS3 1091.67747178604 1201.9198442279 981.435099344185 0.816556198865862 -0.292375913282928 0.0555034479569166 0.855410907895938 13.3359 12.7418 11.737 9.78328 GeneID:60559,Genbank:NM_021928.3,HGNC:HGNC:26212 signal peptidase complex subunit 3 GO:0005787,GO:0005789,GO:0006465,GO:0008233,GO:0016021,GO:0031090,GO:0045047 signal peptidase complex|endoplasmic reticulum membrane|signal peptide processing|peptidase activity|integral component of membrane|organelle membrane|protein targeting to ER hsa03060 Protein export SPDEF 2.97844848768873 4.01662376502878 1.94027321034868 0.483060730567275 -1.04972351828911 0.613585900898606 1 0 0.0413576 0.0441889 0 GeneID:25803,Genbank:XM_005248988.5,HGNC:HGNC:17257,MIM:608144 SAM pointed domain containing ETS transcription factor GO:0000122,GO:0000981,GO:0001227,GO:0005634,GO:0006351,GO:0007275,GO:0010454,GO:0010455,GO:0030154,GO:0043065,GO:0043565,GO:0045944,GO:0060480,GO:0060576 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|transcription, DNA-templated|multicellular organism development|negative regulation of cell fate commitment|positive regulation of cell fate commitment|cell differentiation|positive regulation of apoptotic process|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|lung goblet cell differentiation|intestinal epithelial cell development SPDL1 1201.58801441539 1329.57447210682 1073.60155672396 0.80747756462468 -0.308505919110975 0.27198343419123 1 8.11216 6.71079 7.03132 4.86144 GeneID:54908,Genbank:NM_001329643.1,HGNC:HGNC:26010,MIM:616401 spindle apparatus coiled-coil protein 1 GO:0000132,GO:0000922,GO:0000940,GO:0005634,GO:0005815,GO:0005829,GO:0007062,GO:0007080,GO:0019899,GO:0031577,GO:0034501,GO:0043515,GO:0051301 establishment of mitotic spindle orientation|spindle pole|condensed chromosome outer kinetochore|nucleus|microtubule organizing center|cytosol|sister chromatid cohesion|mitotic metaphase plate congression|enzyme binding|spindle checkpoint|protein localization to kinetochore|kinetochore binding|cell division SPDYA 15.8653918502923 18.1610508368915 13.5697328636932 0.747188749459823 -0.420455362565587 0.599593536301882 1 0.102599 0.139994 0.158944 0.128953 GeneID:245711,Genbank:NM_182756.3,HGNC:HGNC:30613,MIM:614029 speedy/RINGO cell cycle regulator family member A GO:0000082,GO:0005634,GO:0005654,GO:0006974,GO:0007140,GO:0007275,GO:0008284,GO:0019901,GO:0030295,GO:0045737,GO:0045860 G1/S transition of mitotic cell cycle|nucleus|nucleoplasm|cellular response to DNA damage stimulus|male meiotic nuclear division|multicellular organism development|positive regulation of cell proliferation|protein kinase binding|protein kinase activator activity|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of protein kinase activity hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation SPDYE1 2.93975267178729 1.51824048055703 4.36126486301754 2.87257843462153 1.52234628562844 0.472526834103587 1 0 0.0162035 0.0248537 0.0232161 GeneID:285955,Genbank:XM_005249719.3,HGNC:HGNC:16408,MIM:617623 speedy/RINGO cell cycle regulator family member E1 GO:0019901,GO:0045859 protein kinase binding|regulation of protein kinase activity hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation SPDYE18 3.04918294163605 4.16070258908361 1.93766329418849 0.465705791918969 -1.10250927001748 0.610893678309632 1 0.0558886 0.0759862 0 0.0245324 GeneID:100505767,Genbank:NM_001351348.1,HGNC:HGNC:51514 speedy/RINGO cell cycle regulator family member E18 GO:0019901,GO:0045859 protein kinase binding|regulation of protein kinase activity hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation SPDYE2 0.971768182806039 0.490071401957362 1.45346496365472 2.96582285326082 1.56843242909583 0.837471602739444 1 0 0.00838864 0.00862468 0.0241712 GeneID:441273,Genbank:NM_001031618.3,HGNC:HGNC:33841,MIM:617624 speedy/RINGO cell cycle regulator family member E2 GO:0019901,GO:0045859 protein kinase binding|regulation of protein kinase activity hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation SPDYE2B 2.51152025102044 3.084507235799 1.93853326624189 0.628474215830372 -0.670074537921313 0.833675698800589 1 0.0181047 0.0166782 0.0114476 0.0213569 GeneID:100310812,Genbank:XM_005250093.4,HGNC:HGNC:48334 speedy/RINGO cell cycle regulator family member E2B GO:0019901,GO:0045859 protein kinase binding|regulation of protein kinase activity hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation SPDYE3 15.424009556782 16.7966978354972 14.0513212780668 0.836552601926999 -0.257471835970704 0.746939686785587 1 0.0630884 0.12329 0.0673071 0.083983 GeneID:441272,Genbank:XM_011516235.3,HGNC:HGNC:35462,MIM:617625 speedy/RINGO cell cycle regulator family member E3 GO:0019901,GO:0045859 protein kinase binding|regulation of protein kinase activity hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation SPDYE6 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0.0136022 0 0.0128956 0.0120556 GeneID:729597,Genbank:NM_001146210.3,HGNC:HGNC:35465 speedy/RINGO cell cycle regulator family member E6 GO:0019901,GO:0045859 protein kinase binding|regulation of protein kinase activity hsa04114,hsa04914 Oocyte meiosis|Progesterone-mediated oocyte maturation SPECC1 4392.10045923165 4060.45344780075 4723.74747066254 1.16335466749928 0.218290992802476 0.100629662196536 1 11.5059 11.2207 13.8338 12.805 GeneID:92521,Genbank:XM_017025319.1,HGNC:HGNC:30615,MIM:608793 sperm antigen with calponin homology and coiled-coil domains 1 SPECC1L 1667.32192863812 1622.38519644708 1712.25866082916 1.05539588537845 0.0777842640883583 0.590931351098332 1 7.0918 7.20316 8.12527 7.22088 GeneID:23384,Genbank:NM_015330.4,HGNC:HGNC:29022,MIM:614140 sperm antigen with calponin homology and coiled-coil domains 1 like GO:0005737,GO:0005819,GO:0005921,GO:0007049,GO:0051301 cytoplasm|spindle|gap junction|cell cycle|cell division SPEF1 2.45805589093861 2.00831188251439 2.90779989936283 1.4478826345051 0.533944662172545 0.908771793643536 1 0.037117 0.0630874 0.102117 0.0951506 GeneID:25876,Genbank:XM_005260683.4,HGNC:HGNC:15874,MIM:610674 sperm flagellar 1 GO:0005930,GO:0007026,GO:0008017,GO:0016477,GO:0031514 axoneme|negative regulation of microtubule depolymerization|microtubule binding|cell migration|motile cilium SPEF2 7.77252679101142 8.27337890348227 7.27167467854057 0.878924410857082 -0.18618899865502 0.932622106591679 1 0.0255 0.0154988 0.0308153 0.0114593 GeneID:79925,Genbank:XM_024446219.1,HGNC:HGNC:26293,MIM:610172 sperm flagellar 2 SPEG 659.213888125315 666.648598786026 651.779177464604 0.977695263518892 -0.0325432312626435 0.834914079243267 1 1.40382 1.44621 1.32469 1.53951 GeneID:10290,Genbank:XM_017003157.1,HGNC:HGNC:16901,MIM:615950 SPEG complex locus GO:0004674,GO:0005524,GO:0005634,GO:0007517,GO:0008285,GO:0042692 protein serine/threonine kinase activity|ATP binding|nucleus|muscle organ development|negative regulation of cell proliferation|muscle cell differentiation SPEM1 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0906605 0 0 GeneID:374768,Genbank:NM_199339.2,HGNC:HGNC:32429,MIM:615116 spermatid maturation 1 GO:0005737,GO:0007291,GO:0016021,GO:0030317 cytoplasm|sperm individualization|integral component of membrane|flagellated sperm motility SPEM2 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.0167651 0 GeneID:201243,Genbank:XM_011523722.2,HGNC:HGNC:27315 SPEM family member 2 GO:0016021 integral component of membrane SPEM3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00747263 GeneID:107983988,Genbank:XM_011523796.2,HGNC:HGNC:53651 SPEM family member 3 GO:0005737,GO:0007283,GO:0007291,GO:0016021,GO:0030317 cytoplasm|spermatogenesis|sperm individualization|integral component of membrane|flagellated sperm motility SPEN 1223.64352703178 1334.45760281789 1112.82945124568 0.83391892623324 -0.262020963503675 0.129272319449536 1 3.39155 3.05784 3.15179 2.32962 GeneID:23013,Genbank:NM_015001.2,HGNC:HGNC:17575,MIM:613484 spen family transcriptional repressor GO:0000122,GO:0000398,GO:0001085,GO:0001191,GO:0003676,GO:0003677,GO:0003723,GO:0005634,GO:0005654,GO:0006351,GO:0007219,GO:0016032,GO:0017053,GO:0045892,GO:0050769,GO:0070062 negative regulation of transcription from RNA polymerase II promoter|mRNA splicing, via spliceosome|RNA polymerase II transcription factor binding|transcriptional repressor activity, RNA polymerase II transcription factor binding|nucleic acid binding|DNA binding|RNA binding|nucleus|nucleoplasm|transcription, DNA-templated|Notch signaling pathway|viral process|transcriptional repressor complex|negative regulation of transcription, DNA-templated|positive regulation of neurogenesis|extracellular exosome SPERT 1.0041559412572 2.00831188251439 0 0 -Inf 0.414392508436943 1 0.0139195 0.037757 0 0 GeneID:220082,Genbank:XM_011534971.2,HGNC:HGNC:30720 spermatid associated GO:0031410,GO:0042802 cytoplasmic vesicle|identical protein binding SPG11 697.638911077789 679.360012270739 715.917809884838 1.05381211280291 0.0756176676483375 0.780193352818366 1 2.67595 2.35785 3.40003 2.1069 GeneID:80208,Genbank:XM_006720700.1,HGNC:HGNC:11226,MIM:610844 SPG11, spatacsin vesicle trafficking associated GO:0005730,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0007268,GO:0008088,GO:0030424,GO:0030425,GO:0031410,GO:0045202,GO:0048489,GO:0048675,GO:0070062,GO:0090389,GO:0090659 nucleolus|cytoplasm|lysosomal membrane|cytosol|plasma membrane|chemical synaptic transmission|axo-dendritic transport|axon|dendrite|cytoplasmic vesicle|synapse|synaptic vesicle transport|axon extension|extracellular exosome|phagosome-lysosome fusion involved in apoptotic cell clearance|walking behavior SPG21 1871.28991647943 1899.1077744153 1843.47205854355 0.970704287233576 -0.042896231084037 0.753270981655146 1 31.9988 34.5352 32.8147 32.5089 GeneID:51324,Genbank:NM_001127890.4,HGNC:HGNC:20373,MIM:608181 SPG21, maspardin GO:0005794,GO:0005829,GO:0010008,GO:0030140,GO:0042609,GO:0043231,GO:0050851 Golgi apparatus|cytosol|endosome membrane|trans-Golgi network transport vesicle|CD4 receptor binding|intracellular membrane-bounded organelle|antigen receptor-mediated signaling pathway hsa04144 Endocytosis SPG7 1680.77325695322 1577.22320922871 1784.32330467773 1.13130677651535 0.177990198066942 0.218506166605563 1 8.70577 9.151 10.2078 10.7695 GeneID:6687,Genbank:XM_006721264.4,HGNC:HGNC:11237,MIM:602783 SPG7, paraplegin matrix AAA peptidase subunit SPHK1 402.129711297434 467.932600622434 336.326821972433 0.718750566908692 -0.476436906028501 0.0097222395630366 0.391234645330639 9.04187 7.97674 5.91647 6.23089 GeneID:8877,Genbank:NM_001355139.1,HGNC:HGNC:11240,MIM:603730 sphingosine kinase 1 GO:0000287,GO:0001568,GO:0003677,GO:0003951,GO:0005516,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006670,GO:0006954,GO:0007165,GO:0007420,GO:0008481,GO:0010800,GO:0010803,GO:0017050,GO:0019722,GO:0030148,GO:0030307,GO:0030335,GO:0031398,GO:0032651,GO:0035556,GO:0038036,GO:0042346,GO:0043066,GO:0045766,GO:0045931,GO:0045987,GO:0046512,GO:0046521,GO:0048146,GO:0051092,GO:0051721 magnesium ion binding|blood vessel development|DNA binding|NAD+ kinase activity|calmodulin binding|ATP binding|nucleus|cytoplasm|cytosol|plasma membrane|protein folding|sphingosine metabolic process|inflammatory response|signal transduction|brain development|sphinganine kinase activity|positive regulation of peptidyl-threonine phosphorylation|regulation of tumor necrosis factor-mediated signaling pathway|D-erythro-sphingosine kinase activity|calcium-mediated signaling|sphingolipid biosynthetic process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of protein ubiquitination|regulation of interleukin-1 beta production|intracellular signal transduction|sphingosine-1-phosphate receptor activity|positive regulation of NF-kappaB import into nucleus|negative regulation of apoptotic process|positive regulation of angiogenesis|positive regulation of mitotic cell cycle|positive regulation of smooth muscle contraction|sphingosine biosynthetic process|sphingoid catabolic process|positive regulation of fibroblast proliferation|positive regulation of NF-kappaB transcription factor activity|protein phosphatase 2A binding hsa00600,hsa04020,hsa04071,hsa04072,hsa04370,hsa04371,hsa04666,hsa05152 Sphingolipid metabolism|Calcium signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|VEGF signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Tuberculosis SPHK2 827.098143696763 800.772241441471 853.424045952056 1.06575128580357 0.0918707958801439 0.577772798196796 1 8.36971 8.41377 9.49651 9.22513 GeneID:56848,Genbank:NM_020126.4,HGNC:HGNC:18859,MIM:607092 sphingosine kinase 2 GO:0001568,GO:0003951,GO:0005524,GO:0005765,GO:0005829,GO:0006669,GO:0007420,GO:0007565,GO:0008283,GO:0008284,GO:0008481,GO:0016020,GO:0017016,GO:0017050,GO:0030148,GO:0038036,GO:0043066,GO:0043231,GO:0046512 blood vessel development|NAD+ kinase activity|ATP binding|lysosomal membrane|cytosol|sphinganine-1-phosphate biosynthetic process|brain development|female pregnancy|cell proliferation|positive regulation of cell proliferation|sphinganine kinase activity|membrane|Ras GTPase binding|D-erythro-sphingosine kinase activity|sphingolipid biosynthetic process|sphingosine-1-phosphate receptor activity|negative regulation of apoptotic process|intracellular membrane-bounded organelle|sphingosine biosynthetic process hsa00600,hsa04020,hsa04071,hsa04072,hsa04370,hsa04371,hsa04666,hsa05152 Sphingolipid metabolism|Calcium signaling pathway|Sphingolipid signaling pathway|Phospholipase D signaling pathway|VEGF signaling pathway|Apelin signaling pathway|Fc gamma R-mediated phagocytosis|Tuberculosis SPI1 1.77934968379619 2.10436443188427 1.45433493570811 0.69110412325582 -0.533025008314132 0.969273063831792 1 0.0476152 0.0139333 0.0293812 0 GeneID:6688,Genbank:NM_003120.2,HGNC:HGNC:11241,MIM:165170 Spi-1 proto-oncogene hsa04380,hsa05166,hsa05200,hsa05202,hsa05221 Osteoclast differentiation|Human T-cell leukemia virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia SPIB 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:6689,Genbank:NM_003121.4,HGNC:HGNC:11242,MIM:606802 Spi-B transcription factor GO:0000980,GO:0001205,GO:0005634,GO:0005737,GO:0006357,GO:0030154,GO:0045944 RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|nucleus|cytoplasm|regulation of transcription from RNA polymerase II promoter|cell differentiation|positive regulation of transcription from RNA polymerase II promoter SPIC 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0329592 0 GeneID:121599,Genbank:XM_006719239.3,HGNC:HGNC:29549,MIM:612568 Spi-C transcription factor GO:0000978,GO:0000981,GO:0001077,GO:0001824,GO:0005634,GO:0006357,GO:0030154 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|blastocyst development|nucleus|regulation of transcription from RNA polymerase II promoter|cell differentiation SPICE1 136.283914821038 152.370937386598 120.196892255477 0.78884395093345 -0.342188160276894 0.194324007070418 1 0.913193 0.867357 0.8301 0.656678 GeneID:152185,Genbank:NM_001331078.1,HGNC:HGNC:25083,MIM:613447 spindle and centriole associated protein 1 GO:0005813,GO:0005814,GO:0005819,GO:0046599,GO:0051301,GO:0051310,GO:0090307 centrosome|centriole|spindle|regulation of centriole replication|cell division|metaphase plate congression|mitotic spindle assembly SPIDR 924.795777806184 928.293616152299 921.29793946007 0.992463939673285 -0.0109134107674227 0.941787893183591 1 5.56366 5.41386 6.01737 5.5986 GeneID:23514,Genbank:NM_001352958.1,HGNC:HGNC:28971,MIM:615384 scaffold protein involved in DNA repair GO:0000228,GO:0000724,GO:0005654,GO:0006974,GO:0010569,GO:0031334,GO:0070202,GO:0071479,GO:0072711,GO:0072757,GO:2000781 nuclear chromosome|double-strand break repair via homologous recombination|nucleoplasm|cellular response to DNA damage stimulus|regulation of double-strand break repair via homologous recombination|positive regulation of protein complex assembly|regulation of establishment of protein localization to chromosome|cellular response to ionizing radiation|cellular response to hydroxyurea|cellular response to camptothecin|positive regulation of double-strand break repair SPIN1 2041.63993782873 2110.66742223084 1972.61245342662 0.9345917943537 -0.0975917243839796 0.529174132996305 1 21.0485 19.6875 21.6871 16.9848 GeneID:10927,Genbank:NM_006717.2,HGNC:HGNC:11243,MIM:609936 spindlin 1 GO:0003677,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0007275,GO:0007276,GO:0009303,GO:0016055,GO:0016569,GO:0030177,GO:0031965,GO:0035064,GO:0045893,GO:0051321 DNA binding|nucleus|nucleoplasm|nucleolus|cytosol|multicellular organism development|gamete generation|rRNA transcription|Wnt signaling pathway|covalent chromatin modification|positive regulation of Wnt signaling pathway|nuclear membrane|methylated histone binding|positive regulation of transcription, DNA-templated|meiotic cell cycle SPIN2B 73.1382763998426 67.772915293316 78.5036375063692 1.15833349010606 0.212050672374172 0.564014698106698 1 1.20774 1.44214 1.49662 1.21242 GeneID:474343,Genbank:XM_011530789.2,HGNC:HGNC:33147,MIM:300517 spindlin family member 2B GO:0005654,GO:0005829,GO:0006915,GO:0007049,GO:0007276,GO:0035064,GO:0051726 nucleoplasm|cytosol|apoptotic process|cell cycle|gamete generation|methylated histone binding|regulation of cell cycle SPIN3 172.491481667453 186.992502136192 157.990461198714 0.844902653282025 -0.243142966176037 0.310865680759048 1 1.40015 1.63545 1.35418 1.26138 GeneID:169981,Genbank:XM_017029315.1,HGNC:HGNC:27272 spindlin family member 3 GO:0007276,GO:0035064 gamete generation|methylated histone binding SPIN4 410.816500648906 456.669750031668 364.963251266144 0.799184205305553 -0.323400024210139 0.201182582428859 1 7.24386 5.92398 6.08083 4.54963 GeneID:139886,Genbank:NM_001012968.2,HGNC:HGNC:27040 spindlin family member 4 GO:0007276,GO:0035064 gamete generation|methylated histone binding SPINDOC 972.756395861701 913.284716136107 1032.22807558729 1.1302368881792 0.17662518112199 0.257810788731769 1 10.5671 11.3304 12.7445 13.058 GeneID:144097,Genbank:XM_006718437.1,HGNC:HGNC:25115 spindlin interactor and repressor of chromatin binding GO:0006351,GO:0045892 transcription, DNA-templated|negative regulation of transcription, DNA-templated SPINK1 11.1963694268574 10.2816907859967 12.1110480677181 1.17792377924971 0.236246188696287 0.828595821138812 1 0.674702 0.392185 0.398716 0.820668 GeneID:6690,Genbank:NM_003122.4,HGNC:HGNC:11244,MIM:167790 serine peptidase inhibitor, Kazal type 1 GO:0001669,GO:0004866,GO:0004867,GO:0005615,GO:0010751,GO:0048240,GO:0050732,GO:0060046,GO:0070062,GO:0090281,GO:1900004,GO:2001256 acrosomal vesicle|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular space|negative regulation of nitric oxide mediated signal transduction|sperm capacitation|negative regulation of peptidyl-tyrosine phosphorylation|regulation of acrosome reaction|extracellular exosome|negative regulation of calcium ion import|negative regulation of serine-type endopeptidase activity|regulation of store-operated calcium entry SPINK13 1.4627095568168 1.47021420587209 1.45520490776151 0.989791080748215 -0.0148040531050535 1 1 0 0 0 0 GeneID:153218,Genbank:NM_001040129.2,HGNC:HGNC:27200,MIM:615205 serine peptidase inhibitor, Kazal type 13 (putative) GO:0001669,GO:0004867,GO:0005615,GO:0060046,GO:1900004,GO:1902225 acrosomal vesicle|serine-type endopeptidase inhibitor activity|extracellular space|regulation of acrosome reaction|negative regulation of serine-type endopeptidase activity|negative regulation of acrosome reaction SPINK9 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:643394,Genbank:XM_017009709.1,HGNC:HGNC:32951,MIM:613511 serine peptidase inhibitor, Kazal type 9 GO:0001669,GO:0004867,GO:0005576,GO:0005615,GO:0060046,GO:0070268,GO:1900004 acrosomal vesicle|serine-type endopeptidase inhibitor activity|extracellular region|extracellular space|regulation of acrosome reaction|cornification|negative regulation of serine-type endopeptidase activity SPINT1 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0150468 GeneID:6692,Genbank:XM_011521957.2,HGNC:HGNC:11246,MIM:605123 serine peptidase inhibitor, Kunitz type 1 hsa05202,hsa05215 Transcriptional misregulation in cancer|Prostate cancer SPINT2 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0.0358907 0 0 0 GeneID:10653,Genbank:NM_021102.3,HGNC:HGNC:11247,MIM:605124 serine peptidase inhibitor, Kunitz type 2 GO:0001843,GO:0004866,GO:0004867,GO:0005576,GO:0005737,GO:0005886,GO:0006928,GO:0007163,GO:0016021,GO:0022408,GO:0060672,GO:0071711,GO:0071773,GO:2000146,GO:2000178 neural tube closure|endopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity|extracellular region|cytoplasm|plasma membrane|movement of cell or subcellular component|establishment or maintenance of cell polarity|integral component of membrane|negative regulation of cell-cell adhesion|epithelial cell morphogenesis involved in placental branching|basement membrane organization|cellular response to BMP stimulus|negative regulation of cell motility|negative regulation of neural precursor cell proliferation SPIRE1 880.610642063715 866.083974069038 895.137310058392 1.03354563397918 0.0476020892587816 0.757292118608293 1 4.63938 4.38628 5.02165 4.43643 GeneID:56907,Genbank:XM_024451225.1,HGNC:HGNC:30622,MIM:609216 spire type actin nucleation factor 1 GO:0003779,GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0015031,GO:0016192,GO:0030036,GO:0030659,GO:0036089,GO:0040038,GO:0045010,GO:0046907,GO:0048471,GO:0051295,GO:0070649 actin binding|nucleoplasm|cytosol|cytoskeleton|plasma membrane|cell cortex|protein transport|vesicle-mediated transport|actin cytoskeleton organization|cytoplasmic vesicle membrane|cleavage furrow formation|polar body extrusion after meiotic divisions|actin nucleation|intracellular transport|perinuclear region of cytoplasm|establishment of meiotic spindle localization|formin-nucleated actin cable assembly SPIRE2 408.126002685007 402.869791022545 413.382214347468 1.0260938485813 0.0371626887333751 0.85087893831583 1 2.24548 2.30811 2.41173 2.28943 GeneID:84501,Genbank:XM_011523381.2,HGNC:HGNC:30623,MIM:609217 spire type actin nucleation factor 2 GO:0003779,GO:0005829,GO:0005856,GO:0005886,GO:0005938,GO:0015031,GO:0016192,GO:0030036,GO:0030659,GO:0032154,GO:0036089,GO:0040038,GO:0045010,GO:0046907,GO:0048471,GO:0051295,GO:0070649 actin binding|cytosol|cytoskeleton|plasma membrane|cell cortex|protein transport|vesicle-mediated transport|actin cytoskeleton organization|cytoplasmic vesicle membrane|cleavage furrow|cleavage furrow formation|polar body extrusion after meiotic divisions|actin nucleation|intracellular transport|perinuclear region of cytoplasm|establishment of meiotic spindle localization|formin-nucleated actin cable assembly SPN 4.05127231923485 5.67894306964064 2.42360156882906 0.426769830073754 -1.22846990452973 0.464602126257925 1 0.0407716 0.0263745 0.0164705 0.00512498 GeneID:6693,Genbank:NM_001030288.3,HGNC:HGNC:11249,MIM:182160 sialophorin GO:0004888,GO:0005615,GO:0005886,GO:0005887,GO:0006935,GO:0006955,GO:0006968,GO:0007162,GO:0007163,GO:0007165,GO:0009986,GO:0016020,GO:0030544,GO:0031072,GO:0042535,GO:0042742,GO:0050900,GO:0070062 transmembrane signaling receptor activity|extracellular space|plasma membrane|integral component of plasma membrane|chemotaxis|immune response|cellular defense response|negative regulation of cell adhesion|establishment or maintenance of cell polarity|signal transduction|cell surface|membrane|Hsp70 protein binding|heat shock protein binding|positive regulation of tumor necrosis factor biosynthetic process|defense response to bacterium|leukocyte migration|extracellular exosome hsa04514 Cell adhesion molecules (CAMs) SPNS1 903.54510828162 835.433040811497 971.657175751743 1.16305811272191 0.21792318351891 0.183076854190771 1 11.5619 14.0437 16.2212 15.5087 GeneID:83985,Genbank:XM_024450468.1,HGNC:HGNC:30621,MIM:612583 sphingolipid transporter 1 (putative) GO:0003376,GO:0005743,GO:0005765,GO:0016021,GO:0031982,GO:0040011,GO:0046624,GO:0055085 sphingosine-1-phosphate signaling pathway|mitochondrial inner membrane|lysosomal membrane|integral component of membrane|vesicle|locomotion|sphingolipid transporter activity|transmembrane transport SPNS2 4.42223387215467 2.54640955915669 6.29805818515264 2.47330919824162 1.30644260806009 0.407974169400379 1 0.0157066 0.0133139 0.014456 0.0541178 GeneID:124976,Genbank:NM_001124758.2,HGNC:HGNC:26992,MIM:612584 sphingolipid transporter 2 GO:0001782,GO:0002920,GO:0003376,GO:0005765,GO:0006665,GO:0016021,GO:0031982,GO:0040011,GO:0043029,GO:0046624,GO:0048073,GO:0048535,GO:0055085,GO:0060348,GO:0072676 B cell homeostasis|regulation of humoral immune response|sphingosine-1-phosphate signaling pathway|lysosomal membrane|sphingolipid metabolic process|integral component of membrane|vesicle|locomotion|T cell homeostasis|sphingolipid transporter activity|regulation of eye pigmentation|lymph node development|transmembrane transport|bone development|lymphocyte migration SPOCD1 94.2870572447597 119.767493174627 68.8066213148928 0.574501640562598 -0.799617082210673 0.00865191985891735 0.362097302226572 0.637118 0.506632 0.314255 0.45025 GeneID:90853,Genbank:NM_001281988.1,HGNC:HGNC:26338 SPOC domain containing 1 GO:0006351,GO:0010923 transcription, DNA-templated|negative regulation of phosphatase activity SPOCK1 5886.44260027137 5845.7401954481 5927.14500509463 1.01392549222593 0.0199516405606273 0.894629653799927 1 46.6377 46.5506 54.5877 41.0538 GeneID:6695,Genbank:NM_004598.3,HGNC:HGNC:11251,MIM:602264 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 GO:0001558,GO:0001764,GO:0004867,GO:0004869,GO:0005509,GO:0005578,GO:0005615,GO:0005737,GO:0007155,GO:0007165,GO:0007399,GO:0008191,GO:0010812,GO:0010951,GO:0010977,GO:0014069,GO:0016528,GO:0021953,GO:0022008,GO:0031594,GO:0033268 regulation of cell growth|neuron migration|serine-type endopeptidase inhibitor activity|cysteine-type endopeptidase inhibitor activity|calcium ion binding|proteinaceous extracellular matrix|extracellular space|cytoplasm|cell adhesion|signal transduction|nervous system development|metalloendopeptidase inhibitor activity|negative regulation of cell-substrate adhesion|negative regulation of endopeptidase activity|negative regulation of neuron projection development|postsynaptic density|sarcoplasm|central nervous system neuron differentiation|neurogenesis|neuromuscular junction|node of Ranvier SPOCK2 53.6270428029492 51.9945778813106 55.2595077245879 1.06279365996067 0.0878615266458092 0.835700168634196 1 0.310297 0.23797 0.379634 0.233077 GeneID:9806,Genbank:NM_014767.2,HGNC:HGNC:13564,MIM:607988 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 GO:0005509,GO:0005539,GO:0005578,GO:0007165,GO:0007416,GO:0008191,GO:0010811,GO:0010951,GO:0019800,GO:0030198,GO:0045595,GO:0050840,GO:1990830,GO:2000147 calcium ion binding|glycosaminoglycan binding|proteinaceous extracellular matrix|signal transduction|synapse assembly|metalloendopeptidase inhibitor activity|positive regulation of cell-substrate adhesion|negative regulation of endopeptidase activity|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix organization|regulation of cell differentiation|extracellular matrix binding|cellular response to leukemia inhibitory factor|positive regulation of cell motility SPOCK3 3.16708329287378 2.94042841174417 3.3937381740034 1.15416452937561 0.206848898848995 1 1 0 0.0449049 0.0563036 0 GeneID:50859,Genbank:XM_017008258.1,HGNC:HGNC:13565,MIM:607989 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3 GO:0005509,GO:0005539,GO:0005578,GO:0005615,GO:0007165,GO:0008191,GO:0010951,GO:0019800,GO:0031012,GO:2000146 calcium ion binding|glycosaminoglycan binding|proteinaceous extracellular matrix|extracellular space|signal transduction|metalloendopeptidase inhibitor activity|negative regulation of endopeptidase activity|peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan|extracellular matrix|negative regulation of cell motility SPON1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00688431 GeneID:10418,Genbank:NM_006108.3,HGNC:HGNC:11252,MIM:604989 spondin 1 GO:0005578,GO:0005615,GO:0005788,GO:0007155,GO:0036066,GO:0046872 proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|cell adhesion|protein O-linked fucosylation|metal ion binding SPON2 2.43273779551604 1.96028560782945 2.90518998320264 1.48202382938446 0.567568644849142 0.929524920732978 1 0 0.0880359 0 0.0890594 GeneID:10417,Genbank:NM_001199021.1,HGNC:HGNC:11253,MIM:605918 spondin 2 GO:0001530,GO:0002448,GO:0003823,GO:0005578,GO:0007155,GO:0007411,GO:0008228,GO:0032755,GO:0032760,GO:0043152,GO:0045087,GO:0046872,GO:0050832,GO:0051607,GO:0060907,GO:0070062,GO:0071222 lipopolysaccharide binding|mast cell mediated immunity|antigen binding|proteinaceous extracellular matrix|cell adhesion|axon guidance|opsonization|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|induction of bacterial agglutination|innate immune response|metal ion binding|defense response to fungus|defense response to virus|positive regulation of macrophage cytokine production|extracellular exosome|cellular response to lipopolysaccharide SPOP 940.04508329565 910.823533470358 969.266633120943 1.0641651181628 0.0897220198923809 0.553065469938412 1 9.61096 9.20263 10.2546 9.84142 GeneID:8405,Genbank:NM_001007228.1,HGNC:HGNC:11254,MIM:602650 speckle type BTB/POZ protein GO:0000122,GO:0001085,GO:0005634,GO:0005654,GO:0005737,GO:0016607,GO:0019005,GO:0030162,GO:0031463,GO:0031625,GO:0042593,GO:0042787,GO:0043161,GO:0043433,GO:1902237,GO:2000676 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor binding|nucleus|nucleoplasm|cytoplasm|nuclear speck|SCF ubiquitin ligase complex|regulation of proteolysis|Cul3-RING ubiquitin ligase complex|ubiquitin protein ligase binding|glucose homeostasis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of DNA binding transcription factor activity|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of type B pancreatic cell apoptotic process hsa04340 Hedgehog signaling pathway SPOPL 200.377640635397 221.420944786192 179.334336484603 0.809924899642042 -0.304139954713654 0.386237058536095 1 1.85733 1.35954 1.51829 1.07524 GeneID:339745,Genbank:NM_001001664.2,HGNC:HGNC:27934 speckle type BTB/POZ protein like GO:0005634,GO:0005737,GO:0019005,GO:0030162,GO:0031397,GO:0031463,GO:0031625,GO:0042787,GO:0043161 nucleus|cytoplasm|SCF ubiquitin ligase complex|regulation of proteolysis|negative regulation of protein ubiquitination|Cul3-RING ubiquitin ligase complex|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process hsa04340 Hedgehog signaling pathway SPOUT1 875.608271757073 924.526932415803 826.689611098344 0.894175801821362 -0.161369590680584 0.35753792466181 1 6.65206 6.74695 5.61271 6.73517 GeneID:51490,Genbank:XM_017014804.1,HGNC:HGNC:26933,MIM:617614 SPOUT domain containing methyltransferase 1 GO:0000776,GO:0000777,GO:0003723,GO:0005737,GO:0007049,GO:0008168,GO:0010608,GO:0031616,GO:0035196,GO:0035198,GO:0051301,GO:0051661,GO:0072686 kinetochore|condensed chromosome kinetochore|RNA binding|cytoplasm|cell cycle|methyltransferase activity|posttranscriptional regulation of gene expression|spindle pole centrosome|production of miRNAs involved in gene silencing by miRNA|miRNA binding|cell division|maintenance of centrosome location|mitotic spindle SPP1 10647.2324176388 9180.1462842732 12114.3185510044 1.31962151537365 0.400124205196314 0.00192789561350898 0.155161689175677 124.569 116.776 162.544 154.241 GeneID:6696,Genbank:NM_001251830.1,HGNC:HGNC:11255,MIM:166490 secreted phosphoprotein 1 hsa04151,hsa04371,hsa04510,hsa04512,hsa04620,hsa05165 PI3K-Akt signaling pathway|Apelin signaling pathway|Focal adhesion|ECM-receptor interaction|Toll-like receptor signaling pathway|Human papillomavirus infection SPPL2A 1601.15940555736 1630.09003470774 1572.22877640698 0.964504256164512 -0.0521404902740659 0.734595327146576 1 10.5859 10.0797 10.8268 9.05518 GeneID:84888,Genbank:XM_005254722.3,HGNC:HGNC:30227,MIM:608238 signal peptide peptidase like 2A GO:0005765,GO:0005770,GO:0005886,GO:0006509,GO:0010803,GO:0016020,GO:0030660,GO:0031293,GO:0031902,GO:0033619,GO:0042500,GO:0042803,GO:0043231,GO:0050776,GO:0070062,GO:0071458,GO:0071556 lysosomal membrane|late endosome|plasma membrane|membrane protein ectodomain proteolysis|regulation of tumor necrosis factor-mediated signaling pathway|membrane|Golgi-associated vesicle membrane|membrane protein intracellular domain proteolysis|late endosome membrane|membrane protein proteolysis|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|intracellular membrane-bounded organelle|regulation of immune response|extracellular exosome|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane SPPL2B 637.714101043314 621.19845391954 654.229748167088 1.05317349719584 0.0747431219531027 0.686742938704278 1 2.93525 3.55815 3.52976 3.58595 GeneID:56928,Genbank:XM_011528138.2,HGNC:HGNC:30627,MIM:608239 signal peptide peptidase like 2B GO:0000139,GO:0005654,GO:0005765,GO:0005813,GO:0005886,GO:0006509,GO:0010008,GO:0010803,GO:0015629,GO:0016020,GO:0030660,GO:0031293,GO:0033619,GO:0042500,GO:0042803,GO:0050776,GO:0071458,GO:0071556 Golgi membrane|nucleoplasm|lysosomal membrane|centrosome|plasma membrane|membrane protein ectodomain proteolysis|endosome membrane|regulation of tumor necrosis factor-mediated signaling pathway|actin cytoskeleton|membrane|Golgi-associated vesicle membrane|membrane protein intracellular domain proteolysis|membrane protein proteolysis|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|regulation of immune response|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane SPPL3 969.346789803602 913.226881206314 1025.46669840089 1.12290463575307 0.167235410046521 0.282740820275159 1 10.5005 11.2656 12.5092 11.8044 GeneID:121665,Genbank:NM_139015.4,HGNC:HGNC:30424,MIM:608240 signal peptide peptidase like 3 GO:0005765,GO:0005791,GO:0005794,GO:0005886,GO:0007204,GO:0016020,GO:0030660,GO:0032092,GO:0033116,GO:0033619,GO:0035307,GO:0042500,GO:0042803,GO:0043231,GO:0050852,GO:0051533,GO:0070886,GO:0071458,GO:0071556 lysosomal membrane|rough endoplasmic reticulum|Golgi apparatus|plasma membrane|positive regulation of cytosolic calcium ion concentration|membrane|Golgi-associated vesicle membrane|positive regulation of protein binding|endoplasmic reticulum-Golgi intermediate compartment membrane|membrane protein proteolysis|positive regulation of protein dephosphorylation|aspartic endopeptidase activity, intramembrane cleaving|protein homodimerization activity|intracellular membrane-bounded organelle|T cell receptor signaling pathway|positive regulation of NFAT protein import into nucleus|positive regulation of calcineurin-NFAT signaling cascade|integral component of cytoplasmic side of endoplasmic reticulum membrane|integral component of lumenal side of endoplasmic reticulum membrane SPR 799.407175578125 859.800306738709 739.014044417542 0.859518237694845 -0.21839984302258 0.165172915432791 1 27.6552 28.3776 22.8545 25.1478 GeneID:6697,Genbank:NM_003124.4,HGNC:HGNC:11257,MIM:182125 sepiapterin reductase GO:0004033,GO:0004757,GO:0005654,GO:0005829,GO:0006729,GO:0006809,GO:0050661,GO:0050999,GO:0051186,GO:0055114,GO:0070062 aldo-keto reductase (NADP) activity|sepiapterin reductase activity|nucleoplasm|cytosol|tetrahydrobiopterin biosynthetic process|nitric oxide biosynthetic process|NADP binding|regulation of nitric-oxide synthase activity|cofactor metabolic process|oxidation-reduction process|extracellular exosome hsa00790 Folate biosynthesis SPRED1 946.043667476319 979.411878432463 912.675456520176 0.931860718271972 -0.101813758113513 0.688057022050164 1 5.82423 5.16251 5.99994 4.28292 GeneID:161742,Genbank:XM_005254202.3,HGNC:HGNC:20249,MIM:609291 sprouty related EVH1 domain containing 1 GO:0000165,GO:0000188,GO:0005173,GO:0005634,GO:0005829,GO:0005886,GO:0005901,GO:0006469,GO:0008543,GO:0010801,GO:0010923,GO:0016525,GO:0019901,GO:0019902,GO:0030291,GO:0043408,GO:0043409,GO:0043517,GO:0060979,GO:0070373,GO:0090051,GO:0090311 MAPK cascade|inactivation of MAPK activity|stem cell factor receptor binding|nucleus|cytosol|plasma membrane|caveola|negative regulation of protein kinase activity|fibroblast growth factor receptor signaling pathway|negative regulation of peptidyl-threonine phosphorylation|negative regulation of phosphatase activity|negative regulation of angiogenesis|protein kinase binding|phosphatase binding|protein serine/threonine kinase inhibitor activity|regulation of MAPK cascade|negative regulation of MAPK cascade|positive regulation of DNA damage response, signal transduction by p53 class mediator|vasculogenesis involved in coronary vascular morphogenesis|negative regulation of ERK1 and ERK2 cascade|negative regulation of cell migration involved in sprouting angiogenesis|regulation of protein deacetylation SPRED2 1168.60340817738 1205.98652826933 1131.22028808543 0.938004083435995 -0.0923338916136219 0.526179520598642 1 7.1769 7.72393 7.75514 6.29093 GeneID:200734,Genbank:XM_005264200.5,HGNC:HGNC:17722,MIM:609292 sprouty related EVH1 domain containing 2 GO:0000188,GO:0005173,GO:0005829,GO:0005886,GO:0007275,GO:0008543,GO:0010801,GO:0019901,GO:0030291,GO:0030658,GO:0043517,GO:0090311 inactivation of MAPK activity|stem cell factor receptor binding|cytosol|plasma membrane|multicellular organism development|fibroblast growth factor receptor signaling pathway|negative regulation of peptidyl-threonine phosphorylation|protein kinase binding|protein serine/threonine kinase inhibitor activity|transport vesicle membrane|positive regulation of DNA damage response, signal transduction by p53 class mediator|regulation of protein deacetylation SPRED3 351.462285585334 324.421166090645 378.503405080022 1.16670379322373 0.222438331148617 0.243301273167979 1 2.25359 2.05298 2.66534 2.45038 GeneID:399473,Genbank:XM_011526978.2,HGNC:HGNC:31041,MIM:609293 sprouty related EVH1 domain containing 3 GO:0007275,GO:0009966,GO:0016020 multicellular organism development|regulation of signal transduction|membrane SPRN 8.04364219299097 9.30154798208194 6.7857364039 0.729527646040392 -0.45496544361242 0.711720555128356 1 0.101079 0.0868733 0.106514 0.075002 GeneID:503542,Genbank:NM_001012508.3,HGNC:HGNC:16871,MIM:610447 shadow of prion protein GO:0003676,GO:0005576,GO:0005730,GO:0005829,GO:0005886,GO:0006501,GO:0006606,GO:0031225,GO:0031982 nucleic acid binding|extracellular region|nucleolus|cytosol|plasma membrane|C-terminal protein lipidation|protein import into nucleus|anchored component of membrane|vesicle SPRTN 335.252750632363 390.377874600187 280.12762666454 0.717580695246723 -0.478787016289114 0.0133538938433508 0.47550060184261 2.90093 3.15102 2.37484 2.02309 GeneID:83932,Genbank:NM_001010984.3,HGNC:HGNC:25356,MIM:616086 SprT-like N-terminal domain GO:0003677,GO:0005634,GO:0005654,GO:0005694,GO:0006974,GO:0009411,GO:0016607,GO:0019985,GO:0031398,GO:0043130,GO:0046872,GO:0070530,GO:0070987 DNA binding|nucleus|nucleoplasm|chromosome|cellular response to DNA damage stimulus|response to UV|nuclear speck|translesion synthesis|positive regulation of protein ubiquitination|ubiquitin binding|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|error-free translesion synthesis SPRY1 151.184353596505 133.219935090684 169.148772102325 1.26969565018317 0.344482720153265 0.169055398290543 1 1.91033 1.62219 2.60437 2.08384 GeneID:10252,Genbank:XM_005262686.1,HGNC:HGNC:11269,MIM:602465 sprouty RTK signaling antagonist 1 GO:0000132,GO:0001656,GO:0001657,GO:0001759,GO:0005654,GO:0005794,GO:0005829,GO:0005886,GO:0008285,GO:0034260,GO:0040037,GO:0042059,GO:0043407,GO:0046580,GO:0051387,GO:0060449,GO:0060940,GO:0070373 establishment of mitotic spindle orientation|metanephros development|ureteric bud development|organ induction|nucleoplasm|Golgi apparatus|cytosol|plasma membrane|negative regulation of cell proliferation|negative regulation of GTPase activity|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of Ras protein signal transduction|negative regulation of neurotrophin TRK receptor signaling pathway|bud elongation involved in lung branching|epithelial to mesenchymal transition involved in cardiac fibroblast development|negative regulation of ERK1 and ERK2 cascade SPRY2 793.01219370847 720.477983760472 865.546403656468 1.20135024687198 0.264656821950736 0.0946499979764829 0.995347582134833 9.42135 9.15197 11.7352 11.1953 GeneID:10253,Genbank:NM_005842.3,HGNC:HGNC:11270,MIM:602466 sprouty RTK signaling antagonist 2 GO:0000132,GO:0005634,GO:0005829,GO:0005856,GO:0005874,GO:0005886,GO:0007605,GO:0008285,GO:0010628,GO:0010801,GO:0015630,GO:0016020,GO:0019901,GO:0030291,GO:0030335,GO:0031345,GO:0032587,GO:0033138,GO:0034260,GO:0040037,GO:0042059,GO:0042472,GO:0043066,GO:0043407,GO:0043539,GO:0045165,GO:0045595,GO:0046580,GO:0051387,GO:0051897,GO:0060437,GO:0060449,GO:0070373,GO:0070374,GO:1990830 establishment of mitotic spindle orientation|nucleus|cytosol|cytoskeleton|microtubule|plasma membrane|sensory perception of sound|negative regulation of cell proliferation|positive regulation of gene expression|negative regulation of peptidyl-threonine phosphorylation|microtubule cytoskeleton|membrane|protein kinase binding|protein serine/threonine kinase inhibitor activity|positive regulation of cell migration|negative regulation of cell projection organization|ruffle membrane|positive regulation of peptidyl-serine phosphorylation|negative regulation of GTPase activity|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|inner ear morphogenesis|negative regulation of apoptotic process|negative regulation of MAP kinase activity|protein serine/threonine kinase activator activity|cell fate commitment|regulation of cell differentiation|negative regulation of Ras protein signal transduction|negative regulation of neurotrophin TRK receptor signaling pathway|positive regulation of protein kinase B signaling|lung growth|bud elongation involved in lung branching|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to leukemia inhibitory factor hsa05206 MicroRNAs in cancer SPRY3 0.780196841909191 1.07619535328461 0.484198330533773 0.449916763769675 -1.15226997256519 0.981239839765731 1 0.00489596 0 0 0.00439412 GeneID:10251,Genbank:NM_001304990.1,HGNC:HGNC:11271,MIM:300531 sprouty RTK signaling antagonist 3 GO:0005737,GO:0007275,GO:0009966,GO:0016020,GO:0061564 cytoplasm|multicellular organism development|regulation of signal transduction|membrane|axon development SPRY4 1631.05227149834 1535.24076479464 1726.86377820203 1.12481626191904 0.169689357293674 0.240186987290742 1 9.25304 9.40047 11.8475 9.60702 GeneID:81848,Genbank:NM_001127496.1,HGNC:HGNC:15533,MIM:607984 sprouty RTK signaling antagonist 4 GO:0005737,GO:0005925,GO:0007275,GO:0032587,GO:0070373 cytoplasm|focal adhesion|multicellular organism development|ruffle membrane|negative regulation of ERK1 and ERK2 cascade SPRYD3 801.559744587442 693.43882975941 909.680659415473 1.31183980529485 0.391591556680695 0.0142734464292999 0.494072291254673 8.94299 9.59982 13.3141 11.7177 GeneID:84926,Genbank:NM_032840.2,HGNC:HGNC:25920 SPRY domain containing 3 SPRYD4 260.326642811547 265.267622278714 255.385663344381 0.96274721034763 -0.0547710572062816 0.813977342129049 1 6.47519 5.82863 5.78702 6.20491 GeneID:283377,Genbank:NM_207344.3,HGNC:HGNC:27468 SPRY domain containing 4 GO:0005634,GO:0005739 nucleus|mitochondrion SPRYD7 390.229328413077 401.985700768001 378.472956058153 0.941508504743014 -0.0869539679765324 0.642066625715489 1 3.74898 3.81944 3.48381 3.68688 GeneID:57213,Genbank:NM_001127482.2,HGNC:HGNC:14297,MIM:607866 SPRY domain containing 7 SPSB1 469.625200176831 457.99690241434 481.253497939322 1.05077893628185 0.0714591858789135 0.692426408747429 1 6.38802 6.21387 7.17076 6.31014 GeneID:80176,Genbank:NM_025106.3,HGNC:HGNC:30628,MIM:611657 splA/ryanodine receptor domain and SOCS box containing 1 GO:0000209,GO:0004842,GO:0005829,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|cytosol|post-translational protein modification SPSB2 165.540190884093 168.245327347974 162.835054420212 0.967842952829399 -0.0471551275068309 0.844200472790701 1 4.75054 5.09235 4.97167 4.0858 GeneID:84727,Genbank:NM_032641.3,HGNC:HGNC:29522,MIM:611658 splA/ryanodine receptor domain and SOCS box containing 2 GO:0005829,GO:0016567,GO:0035556,GO:0043687 cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification SPSB3 323.775924243929 331.091077620163 316.460770867694 0.955811836254756 -0.0652014616403888 0.781930207079054 1 6.40454 8.94293 7.65948 7.57258 GeneID:90864,Genbank:NM_080861.3,HGNC:HGNC:30629,MIM:611659 splA/ryanodine receptor domain and SOCS box containing 3 GO:0005829,GO:0016567,GO:0043687 cytosol|protein ubiquitination|post-translational protein modification SPSB4 18.9892208085801 16.162547609485 21.8158940076751 1.34978064936201 0.432724976320826 0.626585365627678 1 0.0246611 0.0526911 0.0727124 0.0339249 GeneID:92369,Genbank:NM_080862.2,HGNC:HGNC:30630,MIM:611660 splA/ryanodine receptor domain and SOCS box containing 4 GO:0005829,GO:0016567,GO:0035556,GO:0043687 cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification SPTAN1 6283.41803815575 5993.65653194582 6573.17954436568 1.09668939308268 0.133154980152386 0.317259559439987 1 19.7601 20.4916 23.4684 21.5312 GeneID:6709,Genbank:NM_001130438.2,HGNC:HGNC:11273,MIM:182810 spectrin alpha, non-erythrocytic 1 GO:0000165,GO:0003779,GO:0005088,GO:0005200,GO:0005509,GO:0005516,GO:0005576,GO:0005829,GO:0006888,GO:0007411,GO:0008091,GO:0015630,GO:0016020,GO:0035580,GO:0043231,GO:0043312,GO:0045296,GO:0051693,GO:0070062,GO:1903561,GO:1904724 MAPK cascade|actin binding|Ras guanyl-nucleotide exchange factor activity|structural constituent of cytoskeleton|calcium ion binding|calmodulin binding|extracellular region|cytosol|ER to Golgi vesicle-mediated transport|axon guidance|spectrin|microtubule cytoskeleton|membrane|specific granule lumen|intracellular membrane-bounded organelle|neutrophil degranulation|cadherin binding|actin filament capping|extracellular exosome|extracellular vesicle|tertiary granule lumen hsa04210 Apoptosis SPTB 48.7910055284617 44.2592966544706 53.3227144024528 1.2047799769332 0.268769698180895 0.560804698309358 1 0.104682 0.0980657 0.156118 0.079036 GeneID:6710,Genbank:XM_017021612.2,HGNC:HGNC:11274,MIM:182870 spectrin beta, erythrocytic GO:0000165,GO:0003779,GO:0005088,GO:0005200,GO:0005794,GO:0005829,GO:0006888,GO:0007411,GO:0008091,GO:0009986,GO:0014731,GO:0015629,GO:0030506,GO:0031235,GO:0043234,GO:0051015,GO:0051693 MAPK cascade|actin binding|Ras guanyl-nucleotide exchange factor activity|structural constituent of cytoskeleton|Golgi apparatus|cytosol|ER to Golgi vesicle-mediated transport|axon guidance|spectrin|cell surface|spectrin-associated cytoskeleton|actin cytoskeleton|ankyrin binding|intrinsic component of the cytoplasmic side of the plasma membrane|protein complex|actin filament binding|actin filament capping SPTBN1 6720.67177136337 6477.31639270301 6964.02715002373 1.07514080335323 0.104525611440055 0.425351275611343 1 15.2004 15.1214 17.9009 15.0915 GeneID:6711,Genbank:NM_003128.2,HGNC:HGNC:11275,MIM:182790 spectrin beta, non-erythrocytic 1 GO:0000165,GO:0000281,GO:0003723,GO:0003779,GO:0005088,GO:0005200,GO:0005516,GO:0005543,GO:0005730,GO:0005737,GO:0005829,GO:0006888,GO:0007009,GO:0007182,GO:0007184,GO:0007411,GO:0008091,GO:0014069,GO:0014731,GO:0030506,GO:0030673,GO:0031430,GO:0032403,GO:0032437,GO:0043001,GO:0043234,GO:0045296,GO:0051020,GO:0051693,GO:0070062,GO:0071709,GO:0072659,GO:1900042,GO:1903076,GO:1903078 MAPK cascade|mitotic cytokinesis|RNA binding|actin binding|Ras guanyl-nucleotide exchange factor activity|structural constituent of cytoskeleton|calmodulin binding|phospholipid binding|nucleolus|cytoplasm|cytosol|ER to Golgi vesicle-mediated transport|plasma membrane organization|common-partner SMAD protein phosphorylation|SMAD protein import into nucleus|axon guidance|spectrin|postsynaptic density|spectrin-associated cytoskeleton|ankyrin binding|axolemma|M band|protein complex binding|cuticular plate|Golgi to plasma membrane protein transport|protein complex|cadherin binding|GTPase binding|actin filament capping|extracellular exosome|membrane assembly|protein localization to plasma membrane|positive regulation of interleukin-2 secretion|regulation of protein localization to plasma membrane|positive regulation of protein localization to plasma membrane SPTBN2 930.018622844655 886.840477740625 973.196767948684 1.09737522404037 0.134056908879599 0.396361726576576 1 1.75335 1.85977 2.21759 1.84297 GeneID:6712,Genbank:XM_005274192.4,HGNC:HGNC:11276,MIM:604985 spectrin beta, non-erythrocytic 2 GO:0000165,GO:0003779,GO:0005088,GO:0005200,GO:0005543,GO:0005615,GO:0005829,GO:0006888,GO:0007411,GO:0007416,GO:0008091,GO:0016192,GO:0016324,GO:0019886,GO:0021692,GO:0030054,GO:0030534,GO:0035264,GO:0043025,GO:0045296,GO:0051693 MAPK cascade|actin binding|Ras guanyl-nucleotide exchange factor activity|structural constituent of cytoskeleton|phospholipid binding|extracellular space|cytosol|ER to Golgi vesicle-mediated transport|axon guidance|synapse assembly|spectrin|vesicle-mediated transport|apical plasma membrane|antigen processing and presentation of exogenous peptide antigen via MHC class II|cerebellar Purkinje cell layer morphogenesis|cell junction|adult behavior|multicellular organism growth|neuronal cell body|cadherin binding|actin filament capping SPTBN4 11.8810570718985 10.6757096385841 13.0864045052128 1.22581120583459 0.293736798457801 0.779818827251594 1 0.0314423 0.0542277 0.0678733 0.040638 GeneID:57731,Genbank:XM_011527173.2,HGNC:HGNC:14896,MIM:606214 spectrin beta, non-erythrocytic 4 GO:0000165,GO:0002028,GO:0003779,GO:0005088,GO:0005200,GO:0005543,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0006888,GO:0007016,GO:0007409,GO:0007411,GO:0007605,GO:0007628,GO:0008091,GO:0009566,GO:0010459,GO:0014704,GO:0016020,GO:0016192,GO:0016363,GO:0016605,GO:0019226,GO:0019902,GO:0021952,GO:0030506,GO:0030507,GO:0033135,GO:0033268,GO:0033270,GO:0040018,GO:0043025,GO:0043194,GO:0043203,GO:0045162,GO:0051693,GO:0061337,GO:0070062,GO:0070852,GO:0072659 MAPK cascade|regulation of sodium ion transport|actin binding|Ras guanyl-nucleotide exchange factor activity|structural constituent of cytoskeleton|phospholipid binding|cytoplasm|cytosol|plasma membrane|adherens junction|ER to Golgi vesicle-mediated transport|cytoskeletal anchoring at plasma membrane|axonogenesis|axon guidance|sensory perception of sound|adult walking behavior|spectrin|fertilization|negative regulation of heart rate|intercalated disc|membrane|vesicle-mediated transport|nuclear matrix|PML body|transmission of nerve impulse|phosphatase binding|central nervous system projection neuron axonogenesis|ankyrin binding|spectrin binding|regulation of peptidyl-serine phosphorylation|node of Ranvier|paranode region of axon|positive regulation of multicellular organism growth|neuronal cell body|axon initial segment|axon hillock|clustering of voltage-gated sodium channels|actin filament capping|cardiac conduction|extracellular exosome|cell body fiber|protein localization to plasma membrane SPTBN5 69.2345981999247 70.6074825005824 67.861713899267 0.961112214965421 -0.0572232117313292 0.881407886466066 1 0.188664 0.192644 0.21219 0.137537 GeneID:51332,Genbank:NM_016642.3,HGNC:HGNC:15680,MIM:605916 spectrin beta, non-erythrocytic 5 GO:0000165,GO:0003779,GO:0005088,GO:0005737,GO:0005829,GO:0006888,GO:0007030,GO:0007041,GO:0007411,GO:0008091,GO:0016020,GO:0019894,GO:0030036,GO:0030507,GO:0032029,GO:0032391,GO:0034452,GO:0043621,GO:0045505,GO:0051260,GO:0051693,GO:0070062,GO:0097381 MAPK cascade|actin binding|Ras guanyl-nucleotide exchange factor activity|cytoplasm|cytosol|ER to Golgi vesicle-mediated transport|Golgi organization|lysosomal transport|axon guidance|spectrin|membrane|kinesin binding|actin cytoskeleton organization|spectrin binding|myosin tail binding|photoreceptor connecting cilium|dynactin binding|protein self-association|dynein intermediate chain binding|protein homooligomerization|actin filament capping|extracellular exosome|photoreceptor disc membrane SPTLC1 1369.90184542172 1455.60804930327 1284.19564154018 0.882239997336411 -0.180756926782291 0.234569622316732 1 9.30568 8.60076 7.59487 8.14791 GeneID:10558,Genbank:NM_001281303.1,HGNC:HGNC:11277,MIM:605712 serine palmitoyltransferase long chain base subunit 1 GO:0004758,GO:0005783,GO:0005789,GO:0006665,GO:0006686,GO:0016021,GO:0017059,GO:0030148,GO:0030170,GO:0035339,GO:0046511,GO:0046512,GO:0046513,GO:1904504 serine C-palmitoyltransferase activity|endoplasmic reticulum|endoplasmic reticulum membrane|sphingolipid metabolic process|sphingomyelin biosynthetic process|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|pyridoxal phosphate binding|SPOTS complex|sphinganine biosynthetic process|sphingosine biosynthetic process|ceramide biosynthetic process|positive regulation of lipophagy hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway SPTLC2 632.623669013734 654.031203848974 611.216134178495 0.934536656021132 -0.0976768419145232 0.69139119665767 1 3.04148 3.08973 3.53309 2.35953 GeneID:9517,Genbank:NM_004863.3,HGNC:HGNC:11278,MIM:605713 serine palmitoyltransferase long chain base subunit 2 GO:0004758,GO:0005739,GO:0005789,GO:0006686,GO:0016021,GO:0017059,GO:0030148,GO:0030170,GO:0046511,GO:0046512,GO:0046513,GO:1904504 serine C-palmitoyltransferase activity|mitochondrion|endoplasmic reticulum membrane|sphingomyelin biosynthetic process|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|pyridoxal phosphate binding|sphinganine biosynthetic process|sphingosine biosynthetic process|ceramide biosynthetic process|positive regulation of lipophagy hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway SPTLC3 133.340526477805 113.530835118128 153.150217837483 1.34897464356826 0.431863230463987 0.0971407197485565 1 0.588747 0.483623 0.766353 0.751727 GeneID:55304,Genbank:NM_018327.3,HGNC:HGNC:16253,MIM:611120 serine palmitoyltransferase long chain base subunit 3 GO:0004758,GO:0005789,GO:0016021,GO:0017059,GO:0030148,GO:0030170,GO:0046520 serine C-palmitoyltransferase activity|endoplasmic reticulum membrane|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|pyridoxal phosphate binding|sphingoid biosynthetic process hsa00600,hsa04071 Sphingolipid metabolism|Sphingolipid signaling pathway SPTSSA 1084.61476168898 1177.20556872193 992.02395465603 0.842693902419311 -0.246919408744553 0.106219066549575 1 22.4293 21.5599 18.9475 18.3733 GeneID:171546,Genbank:NM_138288.3,HGNC:HGNC:20361,MIM:613540 serine palmitoyltransferase small subunit A GO:0004758,GO:0005789,GO:0016021,GO:0017059,GO:0030148,GO:0046513 serine C-palmitoyltransferase activity|endoplasmic reticulum membrane|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|ceramide biosynthetic process SPTSSB 3.55826438156569 4.20872886376855 2.90779989936283 0.690897416651152 -0.533456577436287 0.844116364888654 1 0.0320776 0.0103088 0.0154384 0.0096032 GeneID:165679,Genbank:XM_017005793.2,HGNC:HGNC:24045,MIM:610412 serine palmitoyltransferase small subunit B GO:0004758,GO:0005789,GO:0007029,GO:0016021,GO:0017059,GO:0030148,GO:0046513,GO:1904220 serine C-palmitoyltransferase activity|endoplasmic reticulum membrane|endoplasmic reticulum organization|integral component of membrane|serine C-palmitoyltransferase complex|sphingolipid biosynthetic process|ceramide biosynthetic process|regulation of serine C-palmitoyltransferase activity SPTY2D1 366.622512927668 405.61811433555 327.626911519786 0.807722584225505 -0.3080682166182 0.100048656456676 1 2.50835 2.80593 2.3638 1.96888 GeneID:144108,Genbank:XM_011519919.2,HGNC:HGNC:26818 SPT2 chromatin protein domain containing 1 GO:0001042,GO:0003677,GO:0005730,GO:0006334,GO:0006351,GO:0006355,GO:0010847,GO:0042393,GO:0043486 RNA polymerase I core binding|DNA binding|nucleolus|nucleosome assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of chromatin assembly|histone binding|histone exchange SPTY2D1OS 14.6059010054033 17.0946641387148 12.1171378720919 0.708825734964271 -0.496497110871215 0.529309036210488 1 0.143314 0.131976 0.269577 0.126236 GeneID:100506540,Genbank:NM_001355570.1,HGNC:HGNC:44122 SPTY2D1 opposite strand SPX 9.6263186647039 10.041559412572 9.21107791683585 0.917295565199131 -0.12454143005065 0.924798730371479 1 0.0962143 0.242594 0.241092 0.069282 GeneID:80763,Genbank:NM_030572.3,HGNC:HGNC:28139 spexin hormone GO:0003084,GO:0005184,GO:0005615,GO:0010459,GO:0030133,GO:0031045,GO:0031765,GO:0031766,GO:0032099,GO:0035814,GO:0044539,GO:0045944,GO:0051930,GO:1904306 positive regulation of systemic arterial blood pressure|neuropeptide hormone activity|extracellular space|negative regulation of heart rate|transport vesicle|dense core granule|type 2 galanin receptor binding|type 3 galanin receptor binding|negative regulation of appetite|negative regulation of renal sodium excretion|long-chain fatty acid import|positive regulation of transcription from RNA polymerase II promoter|regulation of sensory perception of pain|positive regulation of gastro-intestinal system smooth muscle contraction SQLE 1415.55406294636 1432.86488506109 1398.24324083163 0.975837467586495 -0.0352872178301233 0.816942182621765 1 17.842 18.1561 19.5043 16.0888 GeneID:6713,Genbank:NM_003129.3,HGNC:HGNC:11279,MIM:602019 squalene epoxidase GO:0004506,GO:0005783,GO:0005789,GO:0006695,GO:0006725,GO:0008203,GO:0010033,GO:0016021,GO:0016126,GO:0031090,GO:0045540,GO:0050660 squalene monooxygenase activity|endoplasmic reticulum|endoplasmic reticulum membrane|cholesterol biosynthetic process|cellular aromatic compound metabolic process|cholesterol metabolic process|response to organic substance|integral component of membrane|sterol biosynthetic process|organelle membrane|regulation of cholesterol biosynthetic process|flavin adenine dinucleotide binding hsa00100 Steroid biosynthesis SQOR 321.553825805413 303.377521771802 339.730129839024 1.11982630702141 0.163274977433166 0.411836587519361 1 5.23803 5.5339 6.30928 5.95571 GeneID:58472,Genbank:NM_001271213.1,HGNC:HGNC:20390,MIM:617658 sulfide quinone oxidoreductase GO:0005743,GO:0048038,GO:0070221,GO:0070224,GO:0070813 mitochondrial inner membrane|quinone binding|sulfide oxidation, using sulfide:quinone oxidoreductase|sulfide:quinone oxidoreductase activity|hydrogen sulfide metabolic process hsa00920 Sulfur metabolism SQSTM1 44762.5752930353 46652.3617309143 42872.7888551564 0.918984318574093 -0.121887851118875 0.423854395412444 1 582.082 586.679 506.136 587.59 GeneID:8878,Genbank:NM_001142298.1,HGNC:HGNC:11280,MIM:601530 sequestosome 1 GO:0000122,GO:0000407,GO:0000422,GO:0000423,GO:0000932,GO:0001934,GO:0002376,GO:0002931,GO:0004674,GO:0005080,GO:0005654,GO:0005737,GO:0005770,GO:0005776,GO:0005783,GO:0005829,GO:0006511,GO:0006914,GO:0006915,GO:0006950,GO:0007032,GO:0008104,GO:0008270,GO:0010821,GO:0016197,GO:0016234,GO:0016235,GO:0016236,GO:0016605,GO:0019899,GO:0019901,GO:0030017,GO:0030154,GO:0030971,GO:0031625,GO:0035255,GO:0035556,GO:0035973,GO:0042169,GO:0042802,GO:0042803,GO:0043065,GO:0043066,GO:0043122,GO:0043130,GO:0043231,GO:0044130,GO:0044753,GO:0044754,GO:0045944,GO:0046578,GO:0051291,GO:0061635,GO:0070062,GO:0070498,GO:0070530,GO:0097225,GO:0097413,GO:0098780,GO:1900273,GO:1903078,GO:1905719 negative regulation of transcription from RNA polymerase II promoter|phagophore assembly site|autophagy of mitochondrion|mitophagy|P-body|positive regulation of protein phosphorylation|immune system process|response to ischemia|protein serine/threonine kinase activity|protein kinase C binding|nucleoplasm|cytoplasm|late endosome|autophagosome|endoplasmic reticulum|cytosol|ubiquitin-dependent protein catabolic process|autophagy|apoptotic process|response to stress|endosome organization|protein localization|zinc ion binding|regulation of mitochondrion organization|endosomal transport|inclusion body|aggresome|macroautophagy|PML body|enzyme binding|protein kinase binding|sarcomere|cell differentiation|receptor tyrosine kinase binding|ubiquitin protein ligase binding|ionotropic glutamate receptor binding|intracellular signal transduction|aggrephagy|SH2 domain binding|identical protein binding|protein homodimerization activity|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|intracellular membrane-bounded organelle|negative regulation of growth of symbiont in host|amphisome|autolysosome|positive regulation of transcription from RNA polymerase II promoter|regulation of Ras protein signal transduction|protein heterooligomerization|regulation of protein complex stability|extracellular exosome|interleukin-1-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|sperm midpiece|Lewy body|response to mitochondrial depolarisation|positive regulation of long-term synaptic potentiation|positive regulation of protein localization to plasma membrane|protein localization to perinuclear region of cytoplasm hsa04137,hsa04217,hsa04218,hsa04380,hsa05418 Mitophagy - animal|Necroptosis|Cellular senescence|Osteoclast differentiation|Fluid shear stress and atherosclerosis SRA1 1449.2840707095 1510.20113102184 1388.36701039716 0.919325897642356 -0.12135171262693 0.433413568544503 1 22.0902 24.1302 20.5121 22.4281 GeneID:10011,Genbank:NM_001035235.3,HGNC:HGNC:11281,MIM:603819 steroid receptor RNA activator 1 GO:0003713,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0006355,GO:0006915,GO:0008283,GO:0015630,GO:0030154,GO:0030374,GO:0030529,GO:0042981,GO:0045171,GO:2000273 transcription coactivator activity|RNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|cell proliferation|microtubule cytoskeleton|cell differentiation|ligand-dependent nuclear receptor transcription coactivator activity|intracellular ribonucleoprotein complex|regulation of apoptotic process|intercellular bridge|positive regulation of receptor activity SRBD1 132.114875434507 128.021254767893 136.208496101121 1.06395220346865 0.0894333412830885 0.805141797992028 1 0.903803 0.743284 1.13657 0.751468 GeneID:55133,Genbank:NM_018079.4,HGNC:HGNC:25521 S1 RNA binding domain 1 GO:0003723,GO:0006139 RNA binding|nucleobase-containing compound metabolic process SRC 548.286524135035 574.64167073359 521.93137753648 0.908272762172258 -0.13880247849483 0.410668725855485 1 4.85565 4.71459 4.46259 4.4889 GeneID:6714,Genbank:NM_005417.4,HGNC:HGNC:11283,MIM:190090 SRC proto-oncogene, non-receptor tyrosine kinase GO:0001545,GO:0002102,GO:0004672,GO:0004713,GO:0004715,GO:0005080,GO:0005102,GO:0005158,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0005743,GO:0005764,GO:0005770,GO:0005829,GO:0005884,GO:0005886,GO:0005901,GO:0006468,GO:0007049,GO:0007173,GO:0007179,GO:0007229,GO:0008022,GO:0008283,GO:0009612,GO:0009615,GO:0010447,GO:0010632,GO:0010634,GO:0010641,GO:0010907,GO:0010954,GO:0014069,GO:0014911,GO:0016301,GO:0016310,GO:0016477,GO:0018105,GO:0018108,GO:0019899,GO:0019900,GO:0019904,GO:0020037,GO:0022407,GO:0030331,GO:0030900,GO:0031234,GO:0031625,GO:0031648,GO:0031667,GO:0031954,GO:0032148,GO:0032211,GO:0032463,GO:0032587,GO:0032869,GO:0033146,GO:0034332,GO:0034446,GO:0034614,GO:0035556,GO:0036035,GO:0036120,GO:0038083,GO:0042127,GO:0042169,GO:0042542,GO:0043005,GO:0043065,GO:0043066,GO:0043149,GO:0043154,GO:0043393,GO:0043406,GO:0043552,GO:0044325,GO:0045056,GO:0045087,GO:0045296,GO:0045453,GO:0045737,GO:0045785,GO:0045892,GO:0045893,GO:0046628,GO:0046777,GO:0046875,GO:0048008,GO:0048011,GO:0048471,GO:0048477,GO:0050715,GO:0050731,GO:0050847,GO:0051057,GO:0051219,GO:0051385,GO:0051427,GO:0051602,GO:0051726,GO:0051895,GO:0051897,GO:0051902,GO:0051974,GO:0060065,GO:0060444,GO:0060491,GO:0070374,GO:0070555,GO:0070851,GO:0071222,GO:0071253,GO:0071375,GO:0071393,GO:0071398,GO:0071456,GO:0071498,GO:0071560,GO:0071803,GO:0071902,GO:0086098,GO:0090263,GO:0097110,GO:0098609,GO:1900182,GO:2000386,GO:2000394,GO:2000573,GO:2000641,GO:2000811,GO:2001237,GO:2001243,GO:2001286 primary ovarian follicle growth|podosome|protein kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|protein kinase C binding|receptor binding|insulin receptor binding|ATP binding|nucleus|cytoplasm|mitochondrion|mitochondrial inner membrane|lysosome|late endosome|cytosol|actin filament|plasma membrane|caveola|protein phosphorylation|cell cycle|epidermal growth factor receptor signaling pathway|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|protein C-terminus binding|cell proliferation|response to mechanical stimulus|response to virus|response to acidic pH|regulation of epithelial cell migration|positive regulation of epithelial cell migration|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of glucose metabolic process|positive regulation of protein processing|postsynaptic density|positive regulation of smooth muscle cell migration|kinase activity|phosphorylation|cell migration|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|enzyme binding|kinase binding|protein domain specific binding|heme binding|regulation of cell-cell adhesion|estrogen receptor binding|forebrain development|extrinsic component of cytoplasmic side of plasma membrane|ubiquitin protein ligase binding|protein destabilization|response to nutrient levels|positive regulation of protein autophosphorylation|activation of protein kinase B activity|negative regulation of telomere maintenance via telomerase|negative regulation of protein homooligomerization|ruffle membrane|cellular response to insulin stimulus|regulation of intracellular estrogen receptor signaling pathway|adherens junction organization|substrate adhesion-dependent cell spreading|cellular response to reactive oxygen species|intracellular signal transduction|osteoclast development|cellular response to platelet-derived growth factor stimulus|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|SH2 domain binding|response to hydrogen peroxide|neuron projection|positive regulation of apoptotic process|negative regulation of apoptotic process|stress fiber assembly|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of protein binding|positive regulation of MAP kinase activity|positive regulation of phosphatidylinositol 3-kinase activity|ion channel binding|transcytosis|innate immune response|cadherin binding|bone resorption|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of cell adhesion|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of insulin receptor signaling pathway|protein autophosphorylation|ephrin receptor binding|platelet-derived growth factor receptor signaling pathway|neurotrophin TRK receptor signaling pathway|perinuclear region of cytoplasm|oogenesis|positive regulation of cytokine secretion|positive regulation of peptidyl-tyrosine phosphorylation|progesterone receptor signaling pathway|positive regulation of small GTPase mediated signal transduction|phosphoprotein binding|response to mineralocorticoid|hormone receptor binding|response to electrical stimulus|regulation of cell cycle|negative regulation of focal adhesion assembly|positive regulation of protein kinase B signaling|negative regulation of mitochondrial depolarization|negative regulation of telomerase activity|uterus development|branching involved in mammary gland duct morphogenesis|regulation of cell projection assembly|positive regulation of ERK1 and ERK2 cascade|response to interleukin-1|growth factor receptor binding|cellular response to lipopolysaccharide|connexin binding|cellular response to peptide hormone stimulus|cellular response to progesterone stimulus|cellular response to fatty acid|cellular response to hypoxia|cellular response to fluid shear stress|cellular response to transforming growth factor beta stimulus|positive regulation of podosome assembly|positive regulation of protein serine/threonine kinase activity|angiotensin-activated signaling pathway involved in heart process|positive regulation of canonical Wnt signaling pathway|scaffold protein binding|cell-cell adhesion|positive regulation of protein localization to nucleus|positive regulation of ovarian follicle development|positive regulation of lamellipodium morphogenesis|positive regulation of DNA biosynthetic process|regulation of early endosome to late endosome transport|negative regulation of anoikis|negative regulation of extrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway|regulation of caveolin-mediated endocytosis hsa01521,hsa01522,hsa04012,hsa04015,hsa04062,hsa04137,hsa04144,hsa04360,hsa04370,hsa04510,hsa04520,hsa04530,hsa04540,hsa04611,hsa04625,hsa04727,hsa04750,hsa04810,hsa04912,hsa04915,hsa04917,hsa04919,hsa04921,hsa04926,hsa05100,hsa05120,hsa05131,hsa05152,hsa05161,hsa05163,hsa05167,hsa05203,hsa05205,hsa05219,hsa05418 EGFR tyrosine kinase inhibitor resistance|Endocrine resistance|ErbB signaling pathway|Rap1 signaling pathway|Chemokine signaling pathway|Mitophagy - animal|Endocytosis|Axon guidance|VEGF signaling pathway|Focal adhesion|Adherens junction|Tight junction|Gap junction|Platelet activation|C-type lectin receptor signaling pathway|GABAergic synapse|Inflammatory mediator regulation of TRP channels|Regulation of actin cytoskeleton|GnRH signaling pathway|Estrogen signaling pathway|Prolactin signaling pathway|Thyroid hormone signaling pathway|Oxytocin signaling pathway|Relaxin signaling pathway|Bacterial invasion of epithelial cells|Epithelial cell signaling in Helicobacter pylori infection|Shigellosis|Tuberculosis|Hepatitis B|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Viral carcinogenesis|Proteoglycans in cancer|Bladder cancer|Fluid shear stress and atherosclerosis SRCAP 2788.76668388993 2857.14084160698 2720.39252617287 0.952138055834448 -0.0707573217454679 0.60160371895418 1 9.70946 9.50196 10.1916 8.49193 GeneID:10847,Genbank:NM_006662.2,HGNC:HGNC:16974,MIM:611421 Snf2 related CREBBP activator protein GO:0003677,GO:0003713,GO:0004386,GO:0004402,GO:0005524,GO:0005634,GO:0005654,GO:0005794,GO:0006351,GO:0006357,GO:0016032,GO:0016604,GO:0043234,GO:0048471 DNA binding|transcription coactivator activity|helicase activity|histone acetyltransferase activity|ATP binding|nucleus|nucleoplasm|Golgi apparatus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|viral process|nuclear body|protein complex|perinuclear region of cytoplasm SRCIN1 35.4272376170508 28.6926816514208 42.1617935826809 1.46942673727373 0.555253430845845 0.251603576097453 1 0.0882183 0.0760169 0.149735 0.136496 GeneID:80725,Genbank:XM_017025169.1,HGNC:HGNC:29506,MIM:610786 SRC kinase signaling inhibitor 1 GO:0005737,GO:0006887,GO:0007162,GO:0014069,GO:0015629,GO:0019901,GO:0019904,GO:0030027,GO:0030054,GO:0030175,GO:0030334,GO:0030424,GO:0030425,GO:0034446,GO:0043005,GO:0043025,GO:0045202,GO:0045211,GO:0050709,GO:0061001,GO:0061098,GO:0061099 cytoplasm|exocytosis|negative regulation of cell adhesion|postsynaptic density|actin cytoskeleton|protein kinase binding|protein domain specific binding|lamellipodium|cell junction|filopodium|regulation of cell migration|axon|dendrite|substrate adhesion-dependent cell spreading|neuron projection|neuronal cell body|synapse|postsynaptic membrane|negative regulation of protein secretion|regulation of dendritic spine morphogenesis|positive regulation of protein tyrosine kinase activity|negative regulation of protein tyrosine kinase activity SRD5A1 596.1439979512 541.36585867603 650.922137226371 1.20237012880397 0.265881073081413 0.170129026625398 1 9.22491 10.6009 14.1642 10.272 GeneID:6715,Genbank:NM_001324323.1,HGNC:HGNC:11284,MIM:184753 steroid 5 alpha-reductase 1 hsa00140 Steroid hormone biosynthesis SRD5A2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00650349 GeneID:6716,Genbank:XM_011533072.2,HGNC:HGNC:11285,MIM:607306 steroid 5 alpha-reductase 2 hsa00140,hsa05215 Steroid hormone biosynthesis|Prostate cancer SRD5A3 664.361705307576 598.856066182494 729.867344432657 1.21876922627722 0.285424977784106 0.0813616657564471 0.956746283961275 5.22953 5.38786 6.82688 6.07597 GeneID:79644,Genbank:NM_024592.4,HGNC:HGNC:25812,MIM:611715 steroid 5 alpha-reductase 3 GO:0003865,GO:0005783,GO:0005789,GO:0006486,GO:0006488,GO:0006489,GO:0006702,GO:0016021,GO:0016095,GO:0016628,GO:0019348,GO:0047751,GO:0102389 3-oxo-5-alpha-steroid 4-dehydrogenase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein glycosylation|dolichol-linked oligosaccharide biosynthetic process|dolichyl diphosphate biosynthetic process|androgen biosynthetic process|integral component of membrane|polyprenol catabolic process|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|dolichol metabolic process|cholestenone 5-alpha-reductase activity|polyprenol reductase activity hsa00140 Steroid hormone biosynthesis SREBF1 4703.5063428262 4685.18150508592 4721.83118056648 1.00782246652361 0.0112415225444559 0.95569797559125 1 37.6658 37.8232 36.6671 42.0445 GeneID:6720,Genbank:XM_024450895.1,HGNC:HGNC:11289,MIM:184756 sterol regulatory element binding transcription factor 1 hsa04152,hsa04910,hsa04931,hsa04932 AMPK signaling pathway|Insulin signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD) SREBF2 5306.58737766906 4987.65735329467 5625.51740204344 1.12788770430018 0.17362343607537 0.199557750301279 1 25.4271 27.2394 30.4208 29.8003 GeneID:6721,Genbank:NM_004599.3,HGNC:HGNC:11290,MIM:600481 sterol regulatory element binding transcription factor 2 GO:0000122,GO:0000139,GO:0000978,GO:0001078,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0005829,GO:0006351,GO:0006629,GO:0008022,GO:0008203,GO:0009267,GO:0010886,GO:0012507,GO:0032937,GO:0043231,GO:0045540,GO:0045944,GO:0046983,GO:0070888,GO:0071404,GO:0071499,GO:0072368,GO:0090370,GO:1903146,GO:1903955,GO:2000188 negative regulation of transcription from RNA polymerase II promoter|Golgi membrane|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|transcription, DNA-templated|lipid metabolic process|protein C-terminus binding|cholesterol metabolic process|cellular response to starvation|positive regulation of cholesterol storage|ER to Golgi transport vesicle membrane|SREBP-SCAP-Insig complex|intracellular membrane-bounded organelle|regulation of cholesterol biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|E-box binding|cellular response to low-density lipoprotein particle stimulus|cellular response to laminar fluid shear stress|regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter|negative regulation of cholesterol efflux|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|regulation of cholesterol homeostasis SREK1 356.709358958435 383.785415310677 329.633302606193 0.858900024482047 -0.219437882706426 0.598562501275955 1 1.68881 1.48877 1.86647 0.999494 GeneID:140890,Genbank:NM_001323527.1,HGNC:HGNC:17882,MIM:609268 splicing regulatory glutamic acid and lysine rich protein 1 GO:0000381,GO:0003723,GO:0005654,GO:0005681,GO:0006397,GO:0008380,GO:0016607 regulation of alternative mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex|mRNA processing|RNA splicing|nuclear speck SREK1IP1 248.048880414684 303.712688693742 192.385072135626 0.63344430212339 -0.658710324113263 0.0586829212782227 0.879200811217974 2.24578 1.65559 1.16994 1.26657 GeneID:285672,Genbank:NM_173829.3,HGNC:HGNC:26716 SREK1 interacting protein 1 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding SRF 1368.69442136522 1414.85975570508 1322.52908702536 0.934742176171588 -0.0973596041670508 0.486533368668105 1 12.7339 13.8603 13.1166 13.0182 GeneID:6722,Genbank:NM_003131.3,HGNC:HGNC:11291,MIM:600589 serum response factor GO:0000790,GO:0000978,GO:0001076,GO:0001077,GO:0001228,GO:0001569,GO:0001666,GO:0001707,GO:0001764,GO:0001829,GO:0001947,GO:0002011,GO:0002042,GO:0003257,GO:0003700,GO:0003705,GO:0005634,GO:0005654,GO:0005737,GO:0006366,GO:0007160,GO:0007507,GO:0007616,GO:0008134,GO:0008285,GO:0008306,GO:0009636,GO:0009725,GO:0010669,GO:0010735,GO:0010736,GO:0021766,GO:0022028,GO:0030155,GO:0030168,GO:0030220,GO:0030336,GO:0030878,GO:0031175,GO:0031490,GO:0033561,GO:0034097,GO:0035855,GO:0035912,GO:0042789,GO:0042803,GO:0042826,GO:0043149,GO:0043589,GO:0045059,GO:0045214,GO:0045597,GO:0045773,GO:0045944,GO:0045987,GO:0046016,GO:0046716,GO:0048538,GO:0048589,GO:0048666,GO:0048821,GO:0051091,GO:0051150,GO:0051491,GO:0055003,GO:0060055,GO:0060218,GO:0060261,GO:0060292,GO:0060324,GO:0060347,GO:0060425,GO:0060532,GO:0060534,GO:0060947,GO:0061029,GO:0061145,GO:0070830,GO:0070878,GO:0071333,GO:0090009,GO:0090136,GO:0090398,GO:1900222,GO:1902894,GO:1902895 nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|branching involved in blood vessel morphogenesis|response to hypoxia|mesoderm formation|neuron migration|trophectodermal cell differentiation|heart looping|morphogenesis of an epithelial sheet|cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|nucleoplasm|cytoplasm|transcription from RNA polymerase II promoter|cell-matrix adhesion|heart development|long-term memory|transcription factor binding|negative regulation of cell proliferation|associative learning|response to toxic substance|response to hormone|epithelial structure maintenance|positive regulation of transcription via serum response element binding|serum response element binding|hippocampus development|tangential migration from the subventricular zone to the olfactory bulb|regulation of cell adhesion|platelet activation|platelet formation|negative regulation of cell migration|thyroid gland development|neuron projection development|chromatin DNA binding|regulation of water loss via skin|response to cytokine|megakaryocyte development|dorsal aorta morphogenesis|mRNA transcription from RNA polymerase II promoter|protein homodimerization activity|histone deacetylase binding|stress fiber assembly|skin morphogenesis|positive thymic T cell selection|sarcomere organization|positive regulation of cell differentiation|positive regulation of axon extension|positive regulation of transcription from RNA polymerase II promoter|positive regulation of smooth muscle contraction|positive regulation of transcription by glucose|muscle cell cellular homeostasis|thymus development|developmental growth|neuron development|erythrocyte development|positive regulation of DNA binding transcription factor activity|regulation of smooth muscle cell differentiation|positive regulation of filopodium assembly|cardiac myofibril assembly|angiogenesis involved in wound healing|hematopoietic stem cell differentiation|positive regulation of transcription initiation from RNA polymerase II promoter|long term synaptic depression|face development|heart trabecula formation|lung morphogenesis|bronchus cartilage development|trachea cartilage development|cardiac vascular smooth muscle cell differentiation|eyelid development in camera-type eye|lung smooth muscle development|bicellular tight junction assembly|primary miRNA binding|cellular response to glucose stimulus|primitive streak formation|epithelial cell-cell adhesion|cellular senescence|negative regulation of amyloid-beta clearance|negative regulation of pri-miRNA transcription from RNA polymerase II promoter|positive regulation of pri-miRNA transcription from RNA polymerase II promoter hsa04010,hsa04022,hsa05166,hsa05203 MAPK signaling pathway|cGMP-PKG signaling pathway|Human T-cell leukemia virus 1 infection|Viral carcinogenesis SRFBP1 107.826121584664 119.209778187768 96.4424649815605 0.809014717145544 -0.305762147288021 0.307439614917005 1 1.56013 1.23527 1.10714 1.01617 GeneID:153443,Genbank:NM_152546.2,HGNC:HGNC:26333,MIM:610479 serum response factor binding protein 1 GO:0003723,GO:0005634,GO:0006351,GO:0006355,GO:0030490,GO:0030686,GO:0048471 RNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|maturation of SSU-rRNA|90S preribosome|perinuclear region of cytoplasm SRGAP1 234.210737187067 223.150907675705 245.270566698429 1.09912421711889 0.136354441150206 0.687446299455058 1 0.646413 0.56767 0.843082 0.524973 GeneID:57522,Genbank:XM_011538580.2,HGNC:HGNC:17382,MIM:606523 SLIT-ROBO Rho GTPase activating protein 1 GO:0005096,GO:0005737,GO:0005829,GO:0007165,GO:0030336,GO:0048365,GO:0051056 GTPase activator activity|cytoplasm|cytosol|signal transduction|negative regulation of cell migration|Rac GTPase binding|regulation of small GTPase mediated signal transduction hsa04360 Axon guidance SRGAP2 914.314884302264 867.525779310441 961.103989294087 1.10786792993982 0.147785906497693 0.343485475421424 1 2.9784 3.00282 3.84582 3.03454 GeneID:23380,Genbank:XM_005277510.3,HGNC:HGNC:19751,MIM:606524 SLIT-ROBO Rho GTPase activating protein 2 hsa04360 Axon guidance SRGAP2B 88.6611813728356 94.9277391539639 82.3946235917073 0.867972041955734 -0.204279521781453 0.54163781766933 1 0.311676 0.266243 0.291222 0.209841 GeneID:647135,Genbank:XM_017002092.2,HGNC:HGNC:35237,MIM:614703 SLIT-ROBO Rho GTPase activating protein 2B GO:0005096,GO:0005737,GO:0007399,GO:0030336,GO:0048365 GTPase activator activity|cytoplasm|nervous system development|negative regulation of cell migration|Rac GTPase binding SRGAP2C 474.120283991067 496.998666815372 451.241901166762 0.907933826177431 -0.13934094288289 0.653489275723049 1 2.70254 2.09292 2.56433 1.8845 GeneID:653464,Genbank:NM_001329984.1,HGNC:HGNC:30584,MIM:614704 SLIT-ROBO Rho GTPase activating protein 2C GO:0005096,GO:0005737,GO:0021816,GO:0030336,GO:0042803,GO:0046982,GO:0048365,GO:0051490,GO:0061000,GO:2001224 GTPase activator activity|cytoplasm|extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration|negative regulation of cell migration|protein homodimerization activity|protein heterodimerization activity|Rac GTPase binding|negative regulation of filopodium assembly|negative regulation of dendritic spine development|positive regulation of neuron migration SRGAP3 308.403610320709 265.921389814942 350.885830826476 1.31950961549449 0.400001863870454 0.0447159140530094 0.787153801689864 0.538093 0.575938 0.784227 0.687038 GeneID:9901,Genbank:XM_017007576.2,HGNC:HGNC:19744,MIM:606525 SLIT-ROBO Rho GTPase activating protein 3 GO:0005096,GO:0005737,GO:0005829,GO:0007165,GO:0030336,GO:0048365,GO:0051056 GTPase activator activity|cytoplasm|cytosol|signal transduction|negative regulation of cell migration|Rac GTPase binding|regulation of small GTPase mediated signal transduction hsa04360 Axon guidance SRGN 5.48529225889058 6.61105959887042 4.35952491891075 0.659429075432269 -0.60071059541747 0.681215115545405 1 0.0659667 0.0997671 0.0252085 0.0824211 GeneID:5552,Genbank:XM_024448066.1,HGNC:HGNC:9361,MIM:177040 serglycin GO:0002576,GO:0005576,GO:0005615,GO:0005794,GO:0008626,GO:0016485,GO:0030502,GO:0031093,GO:0031214,GO:0033364,GO:0033368,GO:0033371,GO:0033373,GO:0033382,GO:0042629,GO:0050710 platelet degranulation|extracellular region|extracellular space|Golgi apparatus|granzyme-mediated apoptotic signaling pathway|protein processing|negative regulation of bone mineralization|platelet alpha granule lumen|biomineral tissue development|mast cell secretory granule organization|protease localization to mast cell secretory granule|T cell secretory granule organization|maintenance of protease location in mast cell secretory granule|maintenance of granzyme B location in T cell secretory granule|mast cell granule|negative regulation of cytokine secretion SRI 2338.84335892977 2346.25546240168 2331.43125545786 0.993681759219584 -0.00914421282660338 0.945726366451621 1 33.567 36.5431 34.0735 36.1058 GeneID:6717,Genbank:XM_011516528.1,HGNC:HGNC:11292,MIM:182520 sorcin GO:0001508,GO:0002020,GO:0004198,GO:0005102,GO:0005246,GO:0005509,GO:0005654,GO:0005737,GO:0005739,GO:0005789,GO:0005790,GO:0005829,GO:0006508,GO:0006810,GO:0006816,GO:0006880,GO:0006942,GO:0007165,GO:0007507,GO:0007517,GO:0008016,GO:0010459,GO:0010649,GO:0010880,GO:0016020,GO:0016529,GO:0030018,GO:0030315,GO:0030424,GO:0033017,GO:0035774,GO:0042802,GO:0042994,GO:0043679,GO:0044325,GO:0044326,GO:0046982,GO:0051281,GO:0051924,GO:0055118,GO:0060315,GO:0070062,GO:0070491,GO:0086004,GO:1901077,GO:1901841,GO:1901844,GO:2000678 action potential|protease binding|calcium-dependent cysteine-type endopeptidase activity|receptor binding|calcium channel regulator activity|calcium ion binding|nucleoplasm|cytoplasm|mitochondrion|endoplasmic reticulum membrane|smooth endoplasmic reticulum|cytosol|proteolysis|transport|calcium ion transport|intracellular sequestering of iron ion|regulation of striated muscle contraction|signal transduction|heart development|muscle organ development|regulation of heart contraction|negative regulation of heart rate|regulation of cell communication by electrical coupling|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|membrane|sarcoplasmic reticulum|Z disc|T-tubule|axon|sarcoplasmic reticulum membrane|positive regulation of insulin secretion involved in cellular response to glucose stimulus|identical protein binding|cytoplasmic sequestering of transcription factor|axon terminus|ion channel binding|dendritic spine neck|protein heterodimerization activity|positive regulation of release of sequestered calcium ion into cytosol|regulation of calcium ion transport|negative regulation of cardiac muscle contraction|negative regulation of ryanodine-sensitive calcium-release channel activity|extracellular exosome|repressing transcription factor binding|regulation of cardiac muscle cell contraction|regulation of relaxation of muscle|regulation of high voltage-gated calcium channel activity|regulation of cell communication by electrical coupling involved in cardiac conduction|negative regulation of transcription regulatory region DNA binding SRL 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00640723 0 0 0 GeneID:6345,Genbank:XM_017023527.1,HGNC:HGNC:11295,MIM:604992 sarcalumenin GO:0005525,GO:0033018 GTP binding|sarcoplasmic reticulum lumen SRM 2524.34918736928 2868.40572619946 2180.2926485391 0.760106085629636 -0.395727309842997 0.0037165572773854 0.233428946488645 63.7461 69.2815 52.4413 51.5208 GeneID:6723,Genbank:NM_003132.2,HGNC:HGNC:11296,MIM:182891 spermidine synthase GO:0004766,GO:0005829,GO:0006595,GO:0008295,GO:0042802,GO:0042803,GO:1990830 spermidine synthase activity|cytosol|polyamine metabolic process|spermidine biosynthetic process|identical protein binding|protein homodimerization activity|cellular response to leukemia inhibitory factor hsa00270,hsa00330,hsa00410,hsa00480 Cysteine and methionine metabolism|Arginine and proline metabolism|beta-Alanine metabolism|Glutathione metabolism SRMS 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0 0 0 0 GeneID:6725,Genbank:NM_080823.3,HGNC:HGNC:11298,MIM:617797 src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites GO:0004713,GO:0004715,GO:0005102,GO:0005524,GO:0005737,GO:0005829,GO:0007169,GO:0009968,GO:0030154,GO:0031234,GO:0038083,GO:0042127,GO:0045087 protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|receptor binding|ATP binding|cytoplasm|cytosol|transmembrane receptor protein tyrosine kinase signaling pathway|negative regulation of signal transduction|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|innate immune response SRP14 6861.49969799361 6803.02547655589 6919.97391943133 1.01719065190605 0.0245901086754974 0.856260173079172 1 159.581 163.813 154.901 178.115 GeneID:6727,Genbank:NM_003134.5,HGNC:HGNC:11299,MIM:600708 signal recognition particle 14 GO:0005786,GO:0006614,GO:0008312,GO:0030942 signal recognition particle, endoplasmic reticulum targeting|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|endoplasmic reticulum signal peptide binding hsa03060 Protein export SRP19 1036.51629938197 1039.31625933085 1033.71633943309 0.994611919281079 -0.00779437460063212 0.966838586390072 1 6.94692 7.57856 7.45816 7.11284 GeneID:6728,Genbank:NM_001204199.1,HGNC:HGNC:11300,MIM:182175 signal recognition particle 19 GO:0005786,GO:0006614,GO:0008312 signal recognition particle, endoplasmic reticulum targeting|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding hsa03060 Protein export SRP54 881.863983306747 986.8011670814 776.926799532093 0.787318484664911 -0.344980744668098 0.0787884090435119 0.945231254824065 15.4783 13.5159 13.1233 10.0593 GeneID:6729,Genbank:NM_003136.3,HGNC:HGNC:11301,MIM:604857 signal recognition particle 54 GO:0003924,GO:0005525,GO:0005634,GO:0005786,GO:0005829,GO:0006616,GO:0006617,GO:0008144,GO:0008312,GO:0019003,GO:0030942,GO:0042493,GO:0043021,GO:0045047 GTPase activity|GTP binding|nucleus|signal recognition particle, endoplasmic reticulum targeting|cytosol|SRP-dependent cotranslational protein targeting to membrane, translocation|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|drug binding|7S RNA binding|GDP binding|endoplasmic reticulum signal peptide binding|response to drug|ribonucleoprotein complex binding|protein targeting to ER hsa03060 Protein export SRP68 2567.83806853429 2533.26656484723 2602.40957222135 1.02729401174499 0.0388491403532811 0.778167220986599 1 26.6119 26.1476 27.66 27.1261 GeneID:6730,Genbank:NM_001260502.1,HGNC:HGNC:11302,MIM:604858 signal recognition particle 68 hsa03060 Protein export SRP72 3020.62346143886 3141.57399848755 2899.67292439016 0.92300003940259 -0.115597385428101 0.416901877010763 1 24.2027 22.2873 23.6545 19.6169 GeneID:6731,Genbank:NM_006947.3,HGNC:HGNC:11303,MIM:602122 signal recognition particle 72 hsa03060 Protein export SRP9 4347.62741936882 4457.55500085683 4237.69983788082 0.950678081833259 -0.0729711958271237 0.601981526836656 1 123.694 119.499 122.361 110.846 GeneID:6726,Genbank:NM_001130440.1,HGNC:HGNC:11304,MIM:600707 signal recognition particle 9 GO:0005786,GO:0006614,GO:0008312,GO:0045900 signal recognition particle, endoplasmic reticulum targeting|SRP-dependent cotranslational protein targeting to membrane|7S RNA binding|negative regulation of translational elongation hsa03060 Protein export SRPK1 1432.18110446014 1523.27612039296 1341.08608852731 0.880395924660953 -0.18377562785535 0.212171566489603 1 12.265 12.0318 12.2061 9.41671 GeneID:6732,Genbank:NM_003137.4,HGNC:HGNC:11305,MIM:601939 SRSF protein kinase 1 GO:0000245,GO:0000287,GO:0003723,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0005886,GO:0006468,GO:0007059,GO:0008380,GO:0016032,GO:0016363,GO:0035092,GO:0035556,GO:0045070,GO:0045071,GO:0045087,GO:0048024,GO:0050684 spliceosomal complex assembly|magnesium ion binding|RNA binding|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|endoplasmic reticulum|cytosol|plasma membrane|protein phosphorylation|chromosome segregation|RNA splicing|viral process|nuclear matrix|sperm chromatin condensation|intracellular signal transduction|positive regulation of viral genome replication|negative regulation of viral genome replication|innate immune response|regulation of mRNA splicing, via spliceosome|regulation of mRNA processing hsa05168 Herpes simplex infection SRPK2 1349.63240643808 1251.56113464965 1447.70367822651 1.15671830815661 0.210037572392178 0.149945200286667 1 5.84927 6.01529 7.59935 6.02231 GeneID:6733,Genbank:XM_024446895.1,HGNC:HGNC:11306,MIM:602980 SRSF protein kinase 2 GO:0000245,GO:0000287,GO:0001525,GO:0003723,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006468,GO:0008284,GO:0008380,GO:0010628,GO:0030154,GO:0035063,GO:0035556,GO:0043525,GO:0045070,GO:0045071,GO:0045087,GO:0045787,GO:0048024,GO:0071889 spliceosomal complex assembly|magnesium ion binding|angiogenesis|RNA binding|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|protein phosphorylation|positive regulation of cell proliferation|RNA splicing|positive regulation of gene expression|cell differentiation|nuclear speck organization|intracellular signal transduction|positive regulation of neuron apoptotic process|positive regulation of viral genome replication|negative regulation of viral genome replication|innate immune response|positive regulation of cell cycle|regulation of mRNA splicing, via spliceosome|14-3-3 protein binding SRPK3 5.64915232115487 4.99676656894351 6.30153807336622 1.26112316563521 0.334709181117293 0.883019626755783 1 0.0247545 0.0640025 0.137805 0.0641389 GeneID:26576,Genbank:NM_014370.3,HGNC:HGNC:11402,MIM:301002 SRSF protein kinase 3 GO:0000245,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0007519,GO:0030154,GO:0035556,GO:0050684,GO:0060537 spliceosomal complex assembly|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|skeletal muscle tissue development|cell differentiation|intracellular signal transduction|regulation of mRNA processing|muscle tissue development SRPRA 4447.91722186651 4413.90551346732 4481.9289302657 1.01541116287851 0.0220640254726082 0.872967535170389 1 32.0296 32.9014 34.6434 31.8567 GeneID:6734,Genbank:XM_017018179.2,HGNC:HGNC:11307,MIM:182180 SRP receptor alpha subunit GO:0003723,GO:0003924,GO:0005047,GO:0005525,GO:0005783,GO:0005785,GO:0005789,GO:0006613,GO:0006614,GO:0016020,GO:0016021,GO:0016192,GO:0036498,GO:0070062 RNA binding|GTPase activity|signal recognition particle binding|GTP binding|endoplasmic reticulum|signal recognition particle receptor complex|endoplasmic reticulum membrane|cotranslational protein targeting to membrane|SRP-dependent cotranslational protein targeting to membrane|membrane|integral component of membrane|vesicle-mediated transport|IRE1-mediated unfolded protein response|extracellular exosome hsa03060 Protein export SRPRB 1587.14690656585 1619.64668178919 1554.64713134252 0.959868068031442 -0.0590919710087116 0.679247938411902 1 22.6273 23.9239 22.3684 22.7407 GeneID:58477,Genbank:NM_021203.3,HGNC:HGNC:24085,MIM:616883 SRP receptor beta subunit GO:0005047,GO:0005525,GO:0005737,GO:0005785,GO:0005789,GO:0005881,GO:0007264,GO:0016020,GO:0016021,GO:0036498 signal recognition particle binding|GTP binding|cytoplasm|signal recognition particle receptor complex|endoplasmic reticulum membrane|cytoplasmic microtubule|small GTPase mediated signal transduction|membrane|integral component of membrane|IRE1-mediated unfolded protein response hsa03060 Protein export SRPX 1506.03299179624 1439.41912673103 1572.64685686145 1.09255659290355 0.127708011246862 0.381887118397322 1 24.1839 25.0298 28.5022 25.6977 GeneID:8406,Genbank:NM_001170750.1,HGNC:HGNC:11309,MIM:300187 sushi repeat containing protein, X-linked GO:0001845,GO:0005776,GO:0005783,GO:0006914,GO:0007155,GO:0009986,GO:0016020,GO:0034976,GO:0060244,GO:2001241 phagolysosome assembly|autophagosome|endoplasmic reticulum|autophagy|cell adhesion|cell surface|membrane|response to endoplasmic reticulum stress|negative regulation of cell proliferation involved in contact inhibition|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand SRPX2 312.248456889245 277.481189708071 347.015724070419 1.25059188493282 0.322611060771123 0.106043658548634 1 4.03906 4.59157 5.88042 4.89031 GeneID:27286,Genbank:NM_014467.2,HGNC:HGNC:30668,MIM:300642 sushi repeat containing protein, X-linked 2 GO:0001525,GO:0005102,GO:0005615,GO:0005737,GO:0009986,GO:0030054,GO:0036458,GO:0042325,GO:0042802,GO:0048870,GO:0051965,GO:0060076,GO:0071625,GO:0090050,GO:0097060,GO:0098609 angiogenesis|receptor binding|extracellular space|cytoplasm|cell surface|cell junction|hepatocyte growth factor binding|regulation of phosphorylation|identical protein binding|cell motility|positive regulation of synapse assembly|excitatory synapse|vocalization behavior|positive regulation of cell migration involved in sprouting angiogenesis|synaptic membrane|cell-cell adhesion SRR 543.83906859289 559.958128984231 527.72000820155 0.942427622506059 -0.0855462697804382 0.635946818745355 1 3.7061 3.47042 3.31312 3.62523 GeneID:63826,Genbank:XM_006721565.3,HGNC:HGNC:14398,MIM:606477 serine racemase GO:0000287,GO:0003941,GO:0005509,GO:0005524,GO:0005737,GO:0005886,GO:0006563,GO:0007420,GO:0007568,GO:0008721,GO:0009069,GO:0016594,GO:0018114,GO:0030165,GO:0030170,GO:0030378,GO:0032496,GO:0042803,GO:0042866,GO:0043025,GO:0043278,GO:0045177,GO:0051289,GO:0070178,GO:0070179 magnesium ion binding|L-serine ammonia-lyase activity|calcium ion binding|ATP binding|cytoplasm|plasma membrane|L-serine metabolic process|brain development|aging|D-serine ammonia-lyase activity|serine family amino acid metabolic process|glycine binding|threonine racemase activity|PDZ domain binding|pyridoxal phosphate binding|serine racemase activity|response to lipopolysaccharide|protein homodimerization activity|pyruvate biosynthetic process|neuronal cell body|response to morphine|apical part of cell|protein homotetramerization|D-serine metabolic process|D-serine biosynthetic process hsa00260 Glycine, serine and threonine metabolism SRRD 702.332798057349 720.863210958807 683.802385155891 0.948588268565374 -0.0761460685395129 0.624742339020468 1 5.52507 6.4325 6.03355 5.75759 GeneID:402055,Genbank:XM_011530178.2,HGNC:HGNC:33910,MIM:602254 SRR1 domain containing GO:0048511 rhythmic process SRRM1 1978.19313178901 2176.7692265653 1779.61703701272 0.817549704072564 -0.29062165095656 0.0402217681186302 0.758464027333929 10.1852 9.62263 8.41117 7.59265 GeneID:10250,Genbank:NM_005839.3,HGNC:HGNC:16638,MIM:605975 serine and arginine repetitive matrix 1 GO:0003677,GO:0003723,GO:0005681,GO:0006397,GO:0008380,GO:0016363,GO:0016607 DNA binding|RNA binding|spliceosomal complex|mRNA processing|RNA splicing|nuclear matrix|nuclear speck hsa03013,hsa03015 RNA transport|mRNA surveillance pathway SRRM2 9060.27419606114 9225.63907611612 8894.90931600616 0.964151018982938 -0.0526689554097277 0.746840999373889 1 26.3784 27.5864 30.33 22.558 GeneID:23524,Genbank:XM_005255226.2,HGNC:HGNC:16639,MIM:606032 serine/arginine repetitive matrix 2 GO:0000398,GO:0003723,GO:0005654,GO:0015030,GO:0016607,GO:0047485,GO:0070742,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|Cajal body|nuclear speck|protein N-terminus binding|C2H2 zinc finger domain binding|catalytic step 2 spliceosome SRRM3 151.225647942498 132.835724893205 169.615570991791 1.2768821875904 0.352625419934977 0.16399914658214 1 1.60056 1.54324 1.97123 2.07938 GeneID:222183,Genbank:NM_001291831.1,HGNC:HGNC:26729 serine/arginine repetitive matrix 3 SRRM5 74.2333767361603 75.7865455131577 72.680207959163 0.95901201812325 -0.0603792000003978 0.904311191169899 1 0.169888 0.114703 0.198089 0.148704 GeneID:100170229,Genbank:NM_001145641.1,HGNC:HGNC:37248 serine/arginine repetitive matrix 5 SRRT 3961.77983249581 4107.56997997527 3815.98968501635 0.929013919085885 -0.106227882729654 0.420580659572297 1 25.7021 26.0284 25.3253 24.3737 GeneID:51593,Genbank:XM_017012290.1,HGNC:HGNC:24101,MIM:614469 serrate, RNA effector molecule GO:0000398,GO:0003677,GO:0003723,GO:0005654,GO:0005737,GO:0006355,GO:0008283,GO:0031053,GO:0042795,GO:0043234,GO:0046685,GO:0050769,GO:0097150 mRNA splicing, via spliceosome|DNA binding|RNA binding|nucleoplasm|cytoplasm|regulation of transcription, DNA-templated|cell proliferation|primary miRNA processing|snRNA transcription from RNA polymerase II promoter|protein complex|response to arsenic-containing substance|positive regulation of neurogenesis|neuronal stem cell population maintenance SRSF1 7879.09670917838 8733.67975578666 7024.5136625701 0.804301721495557 -0.314191286955088 0.0177942851844873 0.546850871863472 72.3826 69.2516 61.8029 53.513 GeneID:6426,Genbank:NM_006924.4,HGNC:HGNC:10780,MIM:600812 serine and arginine rich splicing factor 1 GO:0003723,GO:0005737,GO:0006397,GO:0008380,GO:0016607 RNA binding|cytoplasm|mRNA processing|RNA splicing|nuclear speck hsa03040,hsa04657,hsa05168 Spliceosome|IL-17 signaling pathway|Herpes simplex infection SRSF10 2379.5863451474 2643.15314374099 2116.0195465538 0.80056638093958 -0.320907062562028 0.0221793281376745 0.605151821896072 8.92417 8.57406 7.54262 6.10205 GeneID:10772,Genbank:NM_001191009.2,HGNC:HGNC:16713,MIM:605221 serine and arginine rich splicing factor 10 GO:0000244,GO:0000375,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006355,GO:0006376,GO:0006406,GO:0016482,GO:0016607,GO:0048024,GO:0048025,GO:0050733,GO:0051082 spliceosomal tri-snRNP complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of transcription, DNA-templated|mRNA splice site selection|mRNA export from nucleus|cytosolic transport|nuclear speck|regulation of mRNA splicing, via spliceosome|negative regulation of mRNA splicing, via spliceosome|RS domain binding|unfolded protein binding hsa03040 Spliceosome SRSF11 1478.70125071708 1598.37845540372 1359.02404603045 0.850251729454894 -0.234038059436796 0.263985169228587 1 6.96594 6.06429 6.16903 4.83761 GeneID:9295,Genbank:NM_001350608.1,HGNC:HGNC:10782,MIM:602010 serine and arginine rich splicing factor 11 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0006369,GO:0006397,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|termination of RNA polymerase II transcription|mRNA processing|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing SRSF12 6.85411460181212 9.34957425676688 4.35865494685735 0.466187531876408 -1.10101767459178 0.360218918822993 1 0.0772689 0.053208 0 0.0792618 GeneID:135295,Genbank:XM_017010292.1,HGNC:HGNC:21220 serine and arginine rich splicing factor 12 GO:0000244,GO:0000381,GO:0000395,GO:0003723,GO:0005654,GO:0048025,GO:0050733,GO:0051082 spliceosomal tri-snRNP complex assembly|regulation of alternative mRNA splicing, via spliceosome|mRNA 5'-splice site recognition|RNA binding|nucleoplasm|negative regulation of mRNA splicing, via spliceosome|RS domain binding|unfolded protein binding SRSF2 6487.9736837554 7014.47250551442 5961.47486199639 0.849882134017887 -0.234665320058987 0.0752125361872373 0.94157495521624 111.482 112.079 100.041 93.5068 GeneID:6427,Genbank:NM_001195427.1,HGNC:HGNC:10783,MIM:600813 serine and arginine rich splicing factor 2 GO:0003723,GO:0006397,GO:0008380,GO:0016607,GO:0043484 RNA binding|mRNA processing|RNA splicing|nuclear speck|regulation of RNA splicing hsa03040,hsa05168 Spliceosome|Herpes simplex infection SRSF3 5564.73453863376 5997.36232974996 5132.10674751757 0.855727312331909 -0.224776956930823 0.0904170760532894 0.979717040875575 79.8698 82.6583 69.838 69.4747 GeneID:6428,Genbank:NM_003017.4,HGNC:HGNC:10785,MIM:603364 serine and arginine rich splicing factor 3 hsa03040,hsa05168 Spliceosome|Herpes simplex infection SRSF4 3064.93786187464 3130.04769256317 2999.82803118611 0.958396908236751 -0.0613048408494597 0.650688131228977 1 48.1242 48.1571 47.0391 45.8461 GeneID:6429,Genbank:NM_005626.4,HGNC:HGNC:10786,MIM:601940 serine and arginine rich splicing factor 4 GO:0000375,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0006369,GO:0006397,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124,GO:0032868,GO:0048025,GO:1990825 RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|termination of RNA polymerase II transcription|mRNA processing|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing|response to insulin|negative regulation of mRNA splicing, via spliceosome|sequence-specific mRNA binding hsa03040,hsa05168 Spliceosome|Herpes simplex infection SRSF5 2760.0096551566 2871.66744487462 2648.35186543859 0.922234874433458 -0.116793872402657 0.403805330221996 1 39.4367 37.1269 35.9688 38.9511 GeneID:6430,Genbank:NM_001320214.1,HGNC:HGNC:10787,MIM:600914 serine and arginine rich splicing factor 5 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006369,GO:0006376,GO:0006397,GO:0006405,GO:0006406,GO:0016607,GO:0031124,GO:0032869,GO:0033120,GO:0043422,GO:0051726,GO:0097421 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|nucleolus|cytosol|termination of RNA polymerase II transcription|mRNA splice site selection|mRNA processing|RNA export from nucleus|mRNA export from nucleus|nuclear speck|mRNA 3'-end processing|cellular response to insulin stimulus|positive regulation of RNA splicing|protein kinase B binding|regulation of cell cycle|liver regeneration hsa03040,hsa05168 Spliceosome|Herpes simplex infection SRSF6 3459.90348457506 3722.22505556189 3197.58191358823 0.859051203475803 -0.219183969578286 0.10507528559034 1 45.4246 47.0478 40.7791 38.1295 GeneID:6431,Genbank:NM_006275.5,HGNC:HGNC:10788,MIM:601944 serine and arginine rich splicing factor 6 GO:0000380,GO:0000381,GO:0000398,GO:0003723,GO:0005654,GO:0006369,GO:0006376,GO:0006405,GO:0006406,GO:0010837,GO:0016607,GO:0031124,GO:0032868,GO:0036002,GO:0045617,GO:0048025,GO:0060501,GO:0060548,GO:0061041,GO:2000675 alternative mRNA splicing, via spliceosome|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|nucleoplasm|termination of RNA polymerase II transcription|mRNA splice site selection|RNA export from nucleus|mRNA export from nucleus|regulation of keratinocyte proliferation|nuclear speck|mRNA 3'-end processing|response to insulin|pre-mRNA binding|negative regulation of keratinocyte differentiation|negative regulation of mRNA splicing, via spliceosome|positive regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of cell death|regulation of wound healing|negative regulation of type B pancreatic cell apoptotic process hsa03040,hsa05168 Spliceosome|Herpes simplex infection SRSF7 2929.83530292444 3148.66837183584 2711.00223401303 0.860999608044584 -0.215915514027454 0.116392414428192 1 34.228 34.1289 31.125 29.3096 GeneID:6432,Genbank:NM_001195446.1,HGNC:HGNC:10789,MIM:600572 serine and arginine rich splicing factor 7 GO:0003723,GO:0005654,GO:0005737,GO:0006397,GO:0008270,GO:0008380,GO:0019904,GO:0048025,GO:0051028,GO:1990830 RNA binding|nucleoplasm|cytoplasm|mRNA processing|zinc ion binding|RNA splicing|protein domain specific binding|negative regulation of mRNA splicing, via spliceosome|mRNA transport|cellular response to leukemia inhibitory factor hsa03040,hsa05168 Spliceosome|Herpes simplex infection SRSF8 720.172123115369 711.916447208881 728.427799021857 1.02319282252533 0.0330780491763663 0.842866128161113 1 7.30875 7.53947 8.24128 7.14781 GeneID:10929,Genbank:NM_032102.3,HGNC:HGNC:16988,MIM:603269 serine and arginine rich splicing factor 8 GO:0003723,GO:0005634,GO:0005829,GO:0006397,GO:0008380,GO:0016607 RNA binding|nucleus|cytosol|mRNA processing|RNA splicing|nuclear speck hsa03040,hsa05168 Spliceosome|Herpes simplex infection SRSF9 3696.89550225107 3704.41980595801 3689.37119854414 0.995937661441701 -0.00587265213568806 0.964935744949254 1 142.414 144.804 144.555 145.892 GeneID:8683,Genbank:NM_003769.2,HGNC:HGNC:10791,MIM:601943 serine and arginine rich splicing factor 9 GO:0000398,GO:0003723,GO:0005654,GO:0005730,GO:0006369,GO:0006376,GO:0006397,GO:0006405,GO:0006406,GO:0009636,GO:0019904,GO:0031124,GO:0043279,GO:0048025 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|nucleolus|termination of RNA polymerase II transcription|mRNA splice site selection|mRNA processing|RNA export from nucleus|mRNA export from nucleus|response to toxic substance|protein domain specific binding|mRNA 3'-end processing|response to alkaloid|negative regulation of mRNA splicing, via spliceosome hsa03040,hsa05168 Spliceosome|Herpes simplex infection SRXN1 1603.97350530616 1717.28452663658 1490.66248397574 0.868034656374215 -0.204175451317719 0.153475806659194 1 26.8458 27.4732 23.4377 24.2869 GeneID:140809,Genbank:NM_080725.2,HGNC:HGNC:16132,MIM:617583 sulfiredoxin 1 SS18 732.321921650049 787.586305861598 677.057537438501 0.859661388725923 -0.218159585076362 0.21425533005194 1 6.43816 5.50276 5.68453 4.7982 GeneID:6760,Genbank:NM_001308201.1,HGNC:HGNC:11340,MIM:600192 SS18, nBAF chromatin remodeling complex subunit GO:0003713,GO:0005634,GO:0006351,GO:0006355 transcription coactivator activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated hsa05202 Transcriptional misregulation in cancer SS18L1 416.567128907223 453.65288638077 379.481371433677 0.836501613515939 -0.257559771827322 0.167789724149729 1 2.21483 1.86724 1.82445 1.65358 GeneID:26039,Genbank:NM_001301778.1,HGNC:HGNC:15592,MIM:606472 SS18L1, nBAF chromatin remodeling complex subunit SS18L2 393.367517636831 437.337468292977 349.397566980685 0.798919809785472 -0.323877392523506 0.0797358698732576 0.946740836643754 8.70885 8.64076 6.62664 7.31433 GeneID:51188,Genbank:NM_016305.3,HGNC:HGNC:15593,MIM:606473 SS18 like 2 GO:0003713 transcription coactivator activity SSB 997.229069558539 1115.80358165406 878.654557463016 0.787463467504291 -0.344715100241971 0.0254967429721869 0.63507905978623 15.7011 15.5408 13.1316 11.8591 GeneID:6741,Genbank:NM_003142.4,HGNC:HGNC:11316,MIM:109090 Sjogren syndrome antigen B GO:0000049,GO:0000784,GO:0001682,GO:0003723,GO:0003729,GO:0005634,GO:0005737,GO:0006400,GO:0006409,GO:0008033,GO:0008266,GO:0008334,GO:0030529,GO:0042780,GO:0071045,GO:0075522,GO:1903608,GO:1990825 tRNA binding|nuclear chromosome, telomeric region|tRNA 5'-leader removal|RNA binding|mRNA binding|nucleus|cytoplasm|tRNA modification|tRNA export from nucleus|tRNA processing|poly(U) RNA binding|histone mRNA metabolic process|intracellular ribonucleoprotein complex|tRNA 3'-end processing|nuclear histone mRNA catabolic process|IRES-dependent viral translational initiation|protein localization to cytoplasmic stress granule|sequence-specific mRNA binding hsa05322 Systemic lupus erythematosus SSBP1 2854.67536309875 3112.38652178334 2596.96420441417 0.834396430596979 -0.261195108615316 0.0554784108455311 0.855410907895938 38.2842 43.1515 32.0743 36.1638 GeneID:6742,Genbank:NM_001256511.1,HGNC:HGNC:11317,MIM:600439 single stranded DNA binding protein 1 GO:0003682,GO:0003697,GO:0003723,GO:0005634,GO:0005739,GO:0005759,GO:0006260,GO:0007005,GO:0042645,GO:0051096,GO:0070062,GO:0070584 chromatin binding|single-stranded DNA binding|RNA binding|nucleus|mitochondrion|mitochondrial matrix|DNA replication|mitochondrion organization|mitochondrial nucleoid|positive regulation of helicase activity|extracellular exosome|mitochondrion morphogenesis hsa03030,hsa03430,hsa03440 DNA replication|Mismatch repair|Homologous recombination SSBP2 715.74757869829 612.491821543038 819.003335853541 1.33716615805619 0.419178747786817 0.00996559158084127 0.39802721884976 1.7254 1.92597 2.38625 2.59264 GeneID:23635,Genbank:NM_001256736.2,HGNC:HGNC:15831,MIM:607389 single stranded DNA binding protein 2 GO:0000978,GO:0001077,GO:0003697,GO:0005634,GO:0005737,GO:0006355,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|single-stranded DNA binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter SSBP3 477.159089750315 468.768664602294 485.549514898335 1.03579772191104 0.0507422905834616 0.782342575369348 1 3.69291 3.81619 3.70095 4.3329 GeneID:23648,Genbank:NM_001009955.3,HGNC:HGNC:15674,MIM:607390 single stranded DNA binding protein 3 GO:0000978,GO:0001077,GO:0002244,GO:0003697,GO:0005634,GO:0006461,GO:0008284,GO:0021501,GO:0021547,GO:0043234,GO:0045893,GO:0045944,GO:0060322,GO:0060323,GO:2000744 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|hematopoietic progenitor cell differentiation|single-stranded DNA binding|nucleus|protein complex assembly|positive regulation of cell proliferation|prechordal plate formation|midbrain-hindbrain boundary initiation|protein complex|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|head development|head morphogenesis|positive regulation of anterior head development SSBP4 934.619201354335 1041.05704787632 828.181354832348 0.795519665825975 -0.330030499417248 0.0300404135354922 0.685366471772712 11.8326 12.2323 9.119 10.0485 GeneID:170463,Genbank:XM_017026431.1,HGNC:HGNC:15676,MIM:607391 single stranded DNA binding protein 4 GO:0000978,GO:0001077,GO:0003697,GO:0005634,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|single-stranded DNA binding|nucleus|positive regulation of transcription from RNA polymerase II promoter SSC4D 34.1311208314547 31.9212677112746 36.3409739516349 1.13845647611292 0.187079137415409 0.715543366423128 1 0.508786 0.35158 0.407386 0.629788 GeneID:136853,Genbank:NM_080744.1,HGNC:HGNC:14461,MIM:607639 scavenger receptor cysteine rich family member with 4 domains GO:0005044,GO:0016020,GO:0070062 scavenger receptor activity|membrane|extracellular exosome SSC5D 123.544119830859 116.731012213513 130.357227448206 1.11673174914109 0.159282676724181 0.5756002073339 1 0.583263 0.641321 0.707205 0.734473 GeneID:284297,Genbank:NM_001144950.1,HGNC:HGNC:26641 scavenger receptor cysteine rich family member with 5 domains GO:0001968,GO:0005044,GO:0005615,GO:0005622,GO:0005737,GO:0007275,GO:0016020,GO:0031012,GO:0042494,GO:0043236,GO:0045087,GO:0050829,GO:0050830,GO:0050840,GO:2000483 fibronectin binding|scavenger receptor activity|extracellular space|intracellular|cytoplasm|multicellular organism development|membrane|extracellular matrix|detection of bacterial lipoprotein|laminin binding|innate immune response|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|extracellular matrix binding|negative regulation of interleukin-8 secretion SSFA2 1975.12949373911 1948.02256871165 2002.23641876658 1.0278301960797 0.0396019420528604 0.844026307881375 1 8.81366 7.35428 9.56142 7.05332 GeneID:6744,Genbank:NM_001130445.2,HGNC:HGNC:11319,MIM:118990 sperm specific antigen 2 GO:0005102,GO:0005634,GO:0005829,GO:0005886,GO:0051015 receptor binding|nucleus|cytosol|plasma membrane|actin filament binding SSH1 1556.19607611718 1506.68235331217 1605.70979892218 1.06572549641424 0.0918358846632717 0.527457916015589 1 5.05527 5.158 6.2005 5.01998 GeneID:54434,Genbank:NM_018984.3,HGNC:HGNC:30579,MIM:606778 slingshot protein phosphatase 1 GO:0000902,GO:0003779,GO:0004721,GO:0004725,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006470,GO:0008064,GO:0008138,GO:0010591,GO:0030027,GO:0030036,GO:0030426,GO:0030496,GO:0031915,GO:0032154,GO:0032268,GO:0050770,GO:0071318,GO:0098976,GO:1901216,GO:1904719,GO:1904754,GO:2000463 cell morphogenesis|actin binding|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|cytoplasm|cytosol|cytoskeleton|plasma membrane|protein dephosphorylation|regulation of actin polymerization or depolymerization|protein tyrosine/serine/threonine phosphatase activity|regulation of lamellipodium assembly|lamellipodium|actin cytoskeleton organization|growth cone|midbody|positive regulation of synaptic plasticity|cleavage furrow|regulation of cellular protein metabolic process|regulation of axonogenesis|cellular response to ATP|excitatory chemical synaptic transmission|positive regulation of neuron death|positive regulation of AMPA glutamate receptor clustering|positive regulation of vascular associated smooth muscle cell migration|positive regulation of excitatory postsynaptic potential hsa04360,hsa04810 Axon guidance|Regulation of actin cytoskeleton SSH2 767.345927849761 744.12485556741 790.567000132112 1.06241176358676 0.0873430261708921 0.758231070059797 1 1.87506 1.6538 2.29516 1.49048 GeneID:85464,Genbank:XM_005258058.3,HGNC:HGNC:30580,MIM:606779 slingshot protein phosphatase 2 GO:0003779,GO:0004721,GO:0004725,GO:0005615,GO:0005737,GO:0005856,GO:0006470,GO:0008064,GO:0008138,GO:0010591,GO:0030036,GO:0050770 actin binding|phosphoprotein phosphatase activity|protein tyrosine phosphatase activity|extracellular space|cytoplasm|cytoskeleton|protein dephosphorylation|regulation of actin polymerization or depolymerization|protein tyrosine/serine/threonine phosphatase activity|regulation of lamellipodium assembly|actin cytoskeleton organization|regulation of axonogenesis hsa04360,hsa04810 Axon guidance|Regulation of actin cytoskeleton SSH3 348.289426201443 317.127929991078 379.450922411808 1.19652318993942 0.258848358168835 0.176176887247177 1 3.70904 3.29768 4.12902 4.46421 GeneID:54961,Genbank:NM_017857.3,HGNC:HGNC:30581,MIM:606780 slingshot protein phosphatase 3 GO:0003779,GO:0004725,GO:0005634,GO:0005737,GO:0005856,GO:0008064,GO:0008138,GO:0010591,GO:0050770 actin binding|protein tyrosine phosphatase activity|nucleus|cytoplasm|cytoskeleton|regulation of actin polymerization or depolymerization|protein tyrosine/serine/threonine phosphatase activity|regulation of lamellipodium assembly|regulation of axonogenesis hsa04360,hsa04810 Axon guidance|Regulation of actin cytoskeleton SSMEM1 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0209019 0 0 GeneID:136263,Genbank:XM_011515795.2,HGNC:HGNC:29580 serine rich single-pass membrane protein 1 GO:0016021 integral component of membrane SSNA1 1557.00087730068 1537.55786863634 1576.44388596502 1.02529076669041 0.0360331079497604 0.827166294303982 1 65.1214 68.3011 70.3051 72.0717 GeneID:8636,Genbank:NM_003731.2,HGNC:HGNC:11321,MIM:610882 SS nuclear autoantigen 1 GO:0000086,GO:0005634,GO:0005813,GO:0005829,GO:0010389,GO:0036064,GO:0042073,GO:0042802,GO:0060830,GO:0097711 G2/M transition of mitotic cell cycle|nucleus|centrosome|cytosol|regulation of G2/M transition of mitotic cell cycle|ciliary basal body|intraciliary transport|identical protein binding|ciliary receptor clustering involved in smoothened signaling pathway|ciliary basal body-plasma membrane docking SSPN 51.7555104423161 42.9331612726533 60.5778596119788 1.41098064564289 0.496698198688882 0.20518032839363 1 0.405144 0.271843 0.507283 0.482496 GeneID:8082,Genbank:XM_011520853.3,HGNC:HGNC:11322,MIM:601599 sarcospan GO:0005887,GO:0006936,GO:0007155,GO:0016010,GO:0030054,GO:0030133,GO:0042383,GO:0045211 integral component of plasma membrane|muscle contraction|cell adhesion|dystrophin-associated glycoprotein complex|cell junction|transport vesicle|sarcolemma|postsynaptic membrane SSPO 1.02566752891457 1.56626675524197 0.48506830258717 0.309697119576692 -1.69107012999473 0.789536483244536 1 0.00790201 0.0032915 0 0 GeneID:23145,Genbank:NM_198455.2,HGNC:HGNC:21998,MIM:617356 SCO-spondin GO:0005615,GO:0007155,GO:0007399,GO:0030154,GO:0030414 extracellular space|cell adhesion|nervous system development|cell differentiation|peptidase inhibitor activity SSR1 3750.8031132214 3806.95022881814 3694.65599762466 0.970502837062742 -0.043195664524038 0.86152472729463 1 18.9666 16.0119 19.2673 15.0158 GeneID:6745,Genbank:NM_001292008.1,HGNC:HGNC:11323,MIM:600868 signal sequence receptor subunit 1 GO:0005783,GO:0005789,GO:0006613,GO:0008284,GO:0016021,GO:0036498 endoplasmic reticulum|endoplasmic reticulum membrane|cotranslational protein targeting to membrane|positive regulation of cell proliferation|integral component of membrane|IRE1-mediated unfolded protein response hsa04141 Protein processing in endoplasmic reticulum SSR2 5974.83827797506 5461.99604875957 6487.68050719054 1.1877856463598 0.248274503785018 0.0611377031847493 0.88294089648958 210.686 214.513 258.735 251.663 GeneID:6746,Genbank:NM_003145.3,HGNC:HGNC:11324,MIM:600867 signal sequence receptor subunit 2 GO:0005783,GO:0005789,GO:0006613,GO:0016021 endoplasmic reticulum|endoplasmic reticulum membrane|cotranslational protein targeting to membrane|integral component of membrane hsa04141 Protein processing in endoplasmic reticulum SSR3 3195.12737664744 3362.57251545669 3027.68223783818 0.900406526229808 -0.151351581270262 0.30625892166543 1 28.8633 26.038 27.6915 22.3431 GeneID:6747,Genbank:NM_007107.4,HGNC:HGNC:11325,MIM:606213 signal sequence receptor subunit 3 GO:0005622,GO:0005789,GO:0006614,GO:0016021 intracellular|endoplasmic reticulum membrane|SRP-dependent cotranslational protein targeting to membrane|integral component of membrane hsa04141 Protein processing in endoplasmic reticulum SSR4 4391.36031046039 4517.99478978273 4264.72583113806 0.943942175582533 -0.0832296098293252 0.679966742260398 1 63.2076 65.9822 56.3452 67.1712 GeneID:6748,Genbank:NM_001204527.1,HGNC:HGNC:11326,MIM:300090 signal sequence receptor subunit 4 GO:0005784,GO:0016021,GO:0070062 Sec61 translocon complex|integral component of membrane|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum SSRP1 8358.12609890986 8557.43198522825 8158.82021259148 0.953419229819781 -0.068817371004992 0.594050949585773 1 56.6659 57.7677 53.9065 57.1593 GeneID:6749,Genbank:NM_003146.2,HGNC:HGNC:11327,MIM:604328 structure specific recognition protein 1 GO:0003677,GO:0003682,GO:0003723,GO:0005654,GO:0005694,GO:0005730,GO:0006260,GO:0006281,GO:0006355,GO:0006366,GO:0006368,GO:1901796 DNA binding|chromatin binding|RNA binding|nucleoplasm|chromosome|nucleolus|DNA replication|DNA repair|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|regulation of signal transduction by p53 class mediator SSSCA1 514.339820366234 490.283780013733 538.395860718735 1.09813108788476 0.135050284354824 0.449595150739051 1 21.5899 23.1454 25.8087 28.1546 GeneID:10534,Genbank:NM_001303024.1,HGNC:HGNC:11328,MIM:606044 Sjogren syndrome/scleroderma autoantigen 1 GO:0000278,GO:0042802,GO:0051301 mitotic cell cycle|identical protein binding|cell division SSTR1 0.97013660517434 0 1.94027321034868 Inf Inf 0.496193947515089 1 0 0 0.0436502 0 GeneID:6751,Genbank:NM_001049.2,HGNC:HGNC:11330,MIM:182451 somatostatin receptor 1 GO:0004994,GO:0005737,GO:0005886,GO:0005887,GO:0007166,GO:0007186,GO:0007187,GO:0007215,GO:0007267,GO:0007283,GO:0007584,GO:0007586,GO:0008285,GO:0021549,GO:0030900,GO:0042594,GO:0042923,GO:0043005,GO:0071392,GO:1990830 somatostatin receptor activity|cytoplasm|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|glutamate receptor signaling pathway|cell-cell signaling|spermatogenesis|response to nutrient|digestion|negative regulation of cell proliferation|cerebellum development|forebrain development|response to starvation|neuropeptide binding|neuron projection|cellular response to estradiol stimulus|cellular response to leukemia inhibitory factor hsa04024,hsa04080 cAMP signaling pathway|Neuroactive ligand-receptor interaction SSTR2 9.12917759971795 7.59120240278514 10.6671527966508 1.40519936508834 0.490774829819725 0.699995904162725 1 0.0553556 0.127875 0.223877 0.0612264 GeneID:6752,Genbank:NM_001050.2,HGNC:HGNC:11331,MIM:182452 somatostatin receptor 2 GO:0004994,GO:0005829,GO:0005886,GO:0005887,GO:0006937,GO:0007186,GO:0007187,GO:0007193,GO:0007267,GO:0007283,GO:0007584,GO:0007586,GO:0008285,GO:0021549,GO:0030165,GO:0030432,GO:0030900,GO:0042594,GO:0042923,GO:0043005,GO:0071385,GO:0071392 somatostatin receptor activity|cytosol|plasma membrane|integral component of plasma membrane|regulation of muscle contraction|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|cell-cell signaling|spermatogenesis|response to nutrient|digestion|negative regulation of cell proliferation|cerebellum development|PDZ domain binding|peristalsis|forebrain development|response to starvation|neuropeptide binding|neuron projection|cellular response to glucocorticoid stimulus|cellular response to estradiol stimulus hsa04024,hsa04080,hsa04971 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Gastric acid secretion SSTR3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00557356 0 0 0 GeneID:6753,Genbank:XM_005261721.4,HGNC:HGNC:11332,MIM:182453 somatostatin receptor 3 GO:0004930,GO:0004994,GO:0005102,GO:0005737,GO:0005886,GO:0005887,GO:0007186,GO:0007187,GO:0007218,GO:0007267,GO:0007268,GO:0007283,GO:0008285,GO:0008628,GO:0021549,GO:0030900,GO:0042594,GO:0042923,GO:0043005,GO:0060170,GO:0071385,GO:0071392,GO:0097730 G-protein coupled receptor activity|somatostatin receptor activity|receptor binding|cytoplasm|plasma membrane|integral component of plasma membrane|G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|neuropeptide signaling pathway|cell-cell signaling|chemical synaptic transmission|spermatogenesis|negative regulation of cell proliferation|hormone-mediated apoptotic signaling pathway|cerebellum development|forebrain development|response to starvation|neuropeptide binding|neuron projection|ciliary membrane|cellular response to glucocorticoid stimulus|cellular response to estradiol stimulus|non-motile cilium hsa04080 Neuroactive ligand-receptor interaction SSU72 3206.01131247337 2981.86891773269 3430.15370721405 1.15033685311098 0.202056387388392 0.144274795459087 1 79.7755 88.593 98.5073 96.5808 GeneID:29101,Genbank:NM_014188.2,HGNC:HGNC:25016,MIM:617680 SSU72 homolog, RNA polymerase II CTD phosphatase GO:0005654,GO:0005829,GO:0005847,GO:0006369,GO:0006378,GO:0008420,GO:0070940 nucleoplasm|cytosol|mRNA cleavage and polyadenylation specificity factor complex|termination of RNA polymerase II transcription|mRNA polyadenylation|CTD phosphatase activity|dephosphorylation of RNA polymerase II C-terminal domain hsa03015 mRNA surveillance pathway SSUH2 8.96238100174187 8.71542403075469 9.20933797272905 1.0566712463136 0.0795265923434643 1 1 0.0139456 0.0159963 0.00993016 0.0154335 GeneID:51066,Genbank:XM_017006530.1,HGNC:HGNC:24809,MIM:617479 ssu-2 homolog (C. elegans) GO:0005634,GO:0005737,GO:0042476 nucleus|cytoplasm|odontogenesis SSX1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0262326 0 0 0 GeneID:6756,Genbank:NM_001278691.1,HGNC:HGNC:11335,MIM:312820 SSX family member 1 GO:0003676,GO:0003714,GO:0005634,GO:0006351,GO:0006355 nucleic acid binding|transcription corepressor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated hsa05202 Transcriptional misregulation in cancer SSX2IP 516.606468205095 567.942333238749 465.270603171441 0.819221558143392 -0.287674413952123 0.233590075059087 1 3.81454 3.08642 3.00994 2.60381 GeneID:117178,Genbank:NM_001166294.1,HGNC:HGNC:16509,MIM:608690 SSX family member 2 interacting protein hsa04520 Adherens junction ST13 4432.17710461249 4499.32673988279 4365.02746934219 0.970151251886166 -0.0437184060049997 0.756809248493502 1 51.7985 50.962 51.1088 49.1622 GeneID:6767,Genbank:NM_001278589.1,HGNC:HGNC:11343,MIM:606796 ST13, Hsp70 interacting protein GO:0005737,GO:0005829,GO:0006457,GO:0019904,GO:0030544,GO:0030674,GO:0032403,GO:0032564,GO:0042802,GO:0043234,GO:0046983,GO:0051082,GO:0051085,GO:0051087,GO:0051289,GO:0061084,GO:0070062 cytoplasm|cytosol|protein folding|protein domain specific binding|Hsp70 protein binding|protein binding, bridging|protein complex binding|dATP binding|identical protein binding|protein complex|protein dimerization activity|unfolded protein binding|chaperone cofactor-dependent protein refolding|chaperone binding|protein homotetramerization|negative regulation of protein refolding|extracellular exosome ST14 1.53725051852931 2.10436443188427 0.97013660517434 0.46101169097677 -1.11712475789794 0.810649691230945 1 0.0448447 0.012776 0.0138013 0 GeneID:6768,Genbank:NM_021978.3,HGNC:HGNC:11344,MIM:606797 suppression of tumorigenicity 14 GO:0001843,GO:0004175,GO:0004252,GO:0005886,GO:0005887,GO:0006508,GO:0008236,GO:0016323,GO:0019897,GO:0030216,GO:0060672,GO:0070062,GO:0070268 neural tube closure|endopeptidase activity|serine-type endopeptidase activity|plasma membrane|integral component of plasma membrane|proteolysis|serine-type peptidase activity|basolateral plasma membrane|extrinsic component of plasma membrane|keratinocyte differentiation|epithelial cell morphogenesis involved in placental branching|extracellular exosome|cornification hsa05206 MicroRNAs in cancer ST18 0.97133319677934 0.490071401957362 1.45259499160132 2.96404765876891 1.56756864484914 0.837512515494886 1 0 0 0 0.0024266 GeneID:9705,Genbank:NM_001352871.1,HGNC:HGNC:18695,MIM:617155 ST18, C2H2C-type zinc finger GO:0001047,GO:0003700,GO:0005634,GO:0006351,GO:0008270,GO:0008285,GO:0032993,GO:0033209,GO:0045944,GO:0070102,GO:0070498,GO:2001269 core promoter binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|zinc ion binding|negative regulation of cell proliferation|protein-DNA complex|tumor necrosis factor-mediated signaling pathway|positive regulation of transcription from RNA polymerase II promoter|interleukin-6-mediated signaling pathway|interleukin-1-mediated signaling pathway|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ST20 39.4422073035943 32.8533842405044 46.0310303666841 1.40110467858387 0.486564745656136 0.287926635380973 1 1.13072 1.91208 1.773 2.2994 GeneID:400410,Genbank:NM_001199757.1,HGNC:HGNC:33520 suppressor of tumorigenicity 20 ST20-MTHFS 1.7784797117428 2.10436443188427 1.45259499160132 0.690277296837148 -0.534752059943747 0.969269437705094 1 3.56033e-06 4.72341e-06 1.62396e-05 1.13696e-05 GeneID:100528021,Genbank:NM_001199760.1,HGNC:HGNC:44655 ST20-MTHFS readthrough GO:0005524,GO:0005542,GO:0005737,GO:0005759,GO:0005829,GO:0006536,GO:0009396,GO:0015942,GO:0030272,GO:0035999,GO:0046653,GO:0046655,GO:0046657,GO:0046872 ATP binding|folic acid binding|cytoplasm|mitochondrial matrix|cytosol|glutamate metabolic process|folic acid-containing compound biosynthetic process|formate metabolic process|5-formyltetrahydrofolate cyclo-ligase activity|tetrahydrofolate interconversion|tetrahydrofolate metabolic process|folic acid metabolic process|folic acid catabolic process|metal ion binding hsa00670 One carbon pool by folate ST3GAL1 1906.78186600068 1562.84744243767 2250.71628956369 1.44013819164147 0.526207255299616 0.000203818087766587 0.0358719834469192 5.2874 5.31653 8.33448 7.11971 GeneID:6482,Genbank:XM_006716617.2,HGNC:HGNC:10862,MIM:607187 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 hsa00512,hsa00533,hsa00603,hsa00604 Mucin type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series ST3GAL2 1349.32832300725 1350.93097638826 1347.72566962624 0.997627334913445 -0.00342709944332193 0.95252659964128 1 12.8438 14.3912 13.738 13.5677 GeneID:6483,Genbank:NM_006927.3,HGNC:HGNC:10863,MIM:607188 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 hsa00512,hsa00533,hsa00603,hsa00604 Mucin type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series ST3GAL3 517.727647019949 530.988115340663 504.467178699235 0.950053615372515 -0.0739191620233589 0.650503044795539 1 1.36705 1.59615 1.43615 1.55493 GeneID:6487,Genbank:XM_006710827.4,HGNC:HGNC:10866,MIM:606494 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 hsa00514,hsa00515,hsa00533,hsa00601 Other types of O-glycan biosynthesis|Mannose type O-glycan biosynthesis|Glycosaminoglycan biosynthesis - keratan sulfate|Glycosphingolipid biosynthesis - lacto and neolacto series ST3GAL4 1736.79655056368 1692.72617261148 1780.86692851588 1.05207029780158 0.0732311066276787 0.733789511478875 1 18.6541 21.1257 20.5235 22.7728 GeneID:6484,Genbank:NM_001348396.1,HGNC:HGNC:10864,MIM:104240 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series ST3GAL5 80.7434031871444 91.2188903472607 70.2679160270281 0.770321977821979 -0.376466507891813 0.249617663145645 1 0.38391 0.435219 0.303654 0.353813 GeneID:8869,Genbank:NM_001354226.1,HGNC:HGNC:10872,MIM:604402 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 hsa00604 Glycosphingolipid biosynthesis - ganglio series ST3GAL6 75.0486024532704 51.2163488312436 98.8808560752973 1.93065023828831 0.94908682550478 0.00669242456361355 0.323824386135452 0.301494 0.326959 0.842208 0.593908 GeneID:10402,Genbank:NM_001323360.1,HGNC:HGNC:18080,MIM:607156 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 GO:0000139,GO:0006464,GO:0006486,GO:0006664,GO:0009311,GO:0016021,GO:0052798,GO:0071354 Golgi membrane|cellular protein modification process|protein glycosylation|glycolipid metabolic process|oligosaccharide metabolic process|integral component of membrane|beta-galactoside alpha-2,3-sialyltransferase activity|cellular response to interleukin-6 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series ST5 1494.10210542447 1442.23611062979 1545.96810021916 1.07192441572141 0.100203181067768 0.511687242394644 1 6.62529 7.69772 7.99393 7.80605 GeneID:6764,Genbank:NM_005418.3,HGNC:HGNC:11350,MIM:140750 suppression of tumorigenicity 5 GO:0017112,GO:0070374 Rab guanyl-nucleotide exchange factor activity|positive regulation of ERK1 and ERK2 cascade ST6GAL1 61.8713700626704 59.2878139808781 64.4549261444626 1.08715302212443 0.120555021066698 0.7460820497359 1 0.5119 0.428348 0.531075 0.544427 GeneID:6480,Genbank:NM_173216.2,HGNC:HGNC:10860,MIM:109675 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 hsa00510,hsa00514 N-Glycan biosynthesis|Other types of O-glycan biosynthesis ST6GALNAC2 104.217662906607 80.0148916871422 128.420434126071 1.60495667016828 0.682534348701366 0.0217045277382748 0.600929980812952 0.941423 1.42478 1.91852 1.91743 GeneID:10610,Genbank:NM_006456.2,HGNC:HGNC:10867,MIM:610137 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 ST6GALNAC3 106.717307313657 109.716125106947 103.718489520368 0.945334967118713 -0.0811024747882671 0.810567235632979 1 0.294411 0.243345 0.302141 0.245518 GeneID:256435,Genbank:NM_001349109.1,HGNC:HGNC:19343,MIM:610133 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 hsa00604 Glycosphingolipid biosynthesis - ganglio series ST6GALNAC4 594.499709787931 636.543537858526 552.455881717336 0.867899599728747 -0.204399936262773 0.215619366312142 1 12.6758 12.2118 10.6028 11.1261 GeneID:27090,Genbank:XM_011518529.2,HGNC:HGNC:17846,MIM:606378 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 hsa00604 Glycosphingolipid biosynthesis - ganglio series ST6GALNAC5 95.2090808147047 94.4572850622224 95.9608765671869 1.01591821640834 0.0227842667447594 0.977834235708548 1 0.583277 0.76724 0.773571 0.593107 GeneID:81849,Genbank:NM_030965.2,HGNC:HGNC:19342,MIM:610134 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 hsa00604 Glycosphingolipid biosynthesis - ganglio series ST6GALNAC6 831.339997007095 830.598953375969 832.08104063822 1.00178435965544 0.00257199282775537 0.995562702686662 1 8.25518 8.25082 8.32185 8.38252 GeneID:30815,Genbank:XM_017014660.2,HGNC:HGNC:23364,MIM:610135 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 hsa00604 Glycosphingolipid biosynthesis - ganglio series ST7 784.50996068749 749.025569586984 819.994351787997 1.09474814356491 0.130599003321532 0.394091160714477 1 8.93382 7.82949 9.31557 9.14813 GeneID:7982,Genbank:NM_018412.3,HGNC:HGNC:11351,MIM:600833 suppression of tumorigenicity 7 GO:0016021 integral component of membrane ST7L 297.959963342985 298.861017949708 297.058908736261 0.993970076037984 -0.00872567549561838 0.981299519523834 1 0.997321 0.995235 0.887207 1.07382 GeneID:54879,Genbank:XM_011541628.2,HGNC:HGNC:18441,MIM:617640 suppression of tumorigenicity 7 like GO:0016021,GO:0030308 integral component of membrane|negative regulation of cell growth ST8SIA1 40.7842708940221 24.3879002382823 57.1806415497618 2.34463159973091 1.22936125707148 0.00711813209912533 0.336294996163986 0.0700224 0.103581 0.221058 0.255871 GeneID:6489,Genbank:NM_001304450.1,HGNC:HGNC:10869,MIM:601123 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 hsa00601,hsa00603,hsa00604 Glycosphingolipid biosynthesis - lacto and neolacto series|Glycosphingolipid biosynthesis - globo and isoglobo series|Glycosphingolipid biosynthesis - ganglio series ST8SIA2 34.2112178396981 31.58508378848 36.8373518909162 1.16628950987149 0.221925955443728 0.685182831157265 1 0.238126 0.402646 0.480061 0.336241 GeneID:8128,Genbank:NM_001330416.1,HGNC:HGNC:10870,MIM:602546 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 ST8SIA4 84.0031641961136 87.5580678152424 80.4482605769849 0.918798947765042 -0.122178890386398 0.691108764285996 1 0.365205 0.529379 0.395383 0.405061 GeneID:7903,Genbank:NM_005668.5,HGNC:HGNC:10871,MIM:602547 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 ST8SIA5 1.96548293929615 0.538097676642304 3.39286820195 6.30530171236063 2.65656540600347 0.35496025673407 1 0.0159433 0 0.0148104 0.0276841 GeneID:29906,Genbank:NM_001307987.1,HGNC:HGNC:17827,MIM:607162 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 hsa00604 Glycosphingolipid biosynthesis - ganglio series STAB1 13.7673354758583 14.9324647770376 12.6022061746791 0.84394682075916 -0.244776000983567 0.797422487983835 1 0 0.0056096 0.0060918 0.0113463 GeneID:23166,Genbank:XM_017005998.1,HGNC:HGNC:18628,MIM:608560 stabilin 1 GO:0005041,GO:0005044,GO:0005509,GO:0005540,GO:0005886,GO:0005887,GO:0006898,GO:0006954,GO:0007155,GO:0007267,GO:0015035,GO:0016525,GO:0030169,GO:0030666,GO:0042742 low-density lipoprotein receptor activity|scavenger receptor activity|calcium ion binding|hyaluronic acid binding|plasma membrane|integral component of plasma membrane|receptor-mediated endocytosis|inflammatory response|cell adhesion|cell-cell signaling|protein disulfide oxidoreductase activity|negative regulation of angiogenesis|low-density lipoprotein particle binding|endocytic vesicle membrane|defense response to bacterium STAB2 0.780631827935889 1.07619535328461 0.48506830258717 0.450725141217823 -1.14968016979823 0.981241458110389 1 0 0 0 0 GeneID:55576,Genbank:XM_011538537.2,HGNC:HGNC:18629,MIM:608561 stabilin 2 GO:0001525,GO:0005041,GO:0005044,GO:0005509,GO:0005540,GO:0005829,GO:0005886,GO:0005887,GO:0006897,GO:0006898,GO:0007155,GO:0009897,GO:0015035,GO:0030169,GO:0030214,GO:0030666,GO:0042742,GO:0050830 angiogenesis|low-density lipoprotein receptor activity|scavenger receptor activity|calcium ion binding|hyaluronic acid binding|cytosol|plasma membrane|integral component of plasma membrane|endocytosis|receptor-mediated endocytosis|cell adhesion|external side of plasma membrane|protein disulfide oxidoreductase activity|low-density lipoprotein particle binding|hyaluronan catabolic process|endocytic vesicle membrane|defense response to bacterium|defense response to Gram-positive bacterium STAC 1581.50735784287 1409.54438852184 1753.4703271639 1.24399794816162 0.314984105903003 0.0289813286997932 0.674846840672015 12.8045 13.2436 17.2681 15.1225 GeneID:6769,Genbank:XM_011534037.3,HGNC:HGNC:11353,MIM:602317 SH3 and cysteine rich domain GO:0005829,GO:0006936,GO:0007165,GO:0030315,GO:0034605,GO:0035556,GO:0044325,GO:0046872,GO:1901385,GO:1903078,GO:2001259 cytosol|muscle contraction|signal transduction|T-tubule|cellular response to heat|intracellular signal transduction|ion channel binding|metal ion binding|regulation of voltage-gated calcium channel activity|positive regulation of protein localization to plasma membrane|positive regulation of cation channel activity STAC2 29.4434993350942 19.6312650427635 39.2557336274249 1.99965379418558 0.999750243676809 0.0555461628503856 0.855410907895938 0.198381 0.172934 0.355932 0.343318 GeneID:342667,Genbank:NM_001351360.1,HGNC:HGNC:23990 SH3 and cysteine rich domain 2 GO:0005622,GO:0035556,GO:0046872 intracellular|intracellular signal transduction|metal ion binding STAC3 7.91400529356493 7.10113100082778 8.72687958630208 1.22894220445796 0.297417069247996 0.844591572600217 1 0.075412 0.0685762 0.124035 0.0660859 GeneID:246329,Genbank:NM_001286257.1,HGNC:HGNC:28423,MIM:615521 SH3 and cysteine rich domain 3 GO:0003009,GO:0005654,GO:0005829,GO:0005891,GO:0007274,GO:0031234,GO:0035556,GO:0042802,GO:0046872,GO:0048741,GO:1901387,GO:1903078 skeletal muscle contraction|nucleoplasm|cytosol|voltage-gated calcium channel complex|neuromuscular synaptic transmission|extrinsic component of cytoplasmic side of plasma membrane|intracellular signal transduction|identical protein binding|metal ion binding|skeletal muscle fiber development|positive regulation of voltage-gated calcium channel activity|positive regulation of protein localization to plasma membrane STAG1 380.947024857138 426.468636554798 335.425413159477 0.786518361277847 -0.346447649125243 0.279410753113894 1 2.15097 1.66921 1.85188 1.15282 GeneID:10274,Genbank:XM_017005525.1,HGNC:HGNC:11354,MIM:604358 stromal antigen 1 GO:0000775,GO:0000785,GO:0001228,GO:0003682,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0007062,GO:0008278,GO:0016363,GO:0016604,GO:0051301,GO:0097431,GO:1901673 chromosome, centromeric region|chromatin|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|nucleus|nucleoplasm|chromosome|cytosol|sister chromatid cohesion|cohesin complex|nuclear matrix|nuclear body|cell division|mitotic spindle pole|regulation of mitotic spindle assembly hsa04110 Cell cycle STAG2 537.289949352286 561.743892801827 512.836005902746 0.912935614386226 -0.131414978468833 0.777514658954449 1 3.25498 2.26125 3.18739 1.88956 GeneID:10735,Genbank:NM_001042749.2,HGNC:HGNC:11355,MIM:300826 stromal antigen 2 GO:0000775,GO:0000785,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0007062,GO:0008278,GO:0016020,GO:0016363,GO:0032876,GO:0051301,GO:0051321,GO:0097431,GO:1901673 chromosome, centromeric region|chromatin|nucleus|nucleoplasm|chromosome|cytosol|sister chromatid cohesion|cohesin complex|membrane|nuclear matrix|negative regulation of DNA endoreduplication|cell division|meiotic cell cycle|mitotic spindle pole|regulation of mitotic spindle assembly hsa04110 Cell cycle STAG3 5.56113817868319 7.24520982488261 3.87706653248377 0.535121359655942 -0.902061978852802 0.520141203523817 1 0.0282498 0.00847664 0.00886061 0.0165112 GeneID:10734,Genbank:XM_017011685.1,HGNC:HGNC:11356,MIM:608489 stromal antigen 3 GO:0000775,GO:0000795,GO:0005615,GO:0005634,GO:0007130,GO:0030893 chromosome, centromeric region|synaptonemal complex|extracellular space|nucleus|synaptonemal complex assembly|meiotic cohesin complex hsa04114 Oocyte meiosis STAM 532.661093718334 569.048971558212 496.273215878457 0.872109854657192 -0.197418220450645 0.249401714004416 1 3.1211 3.45423 3.18177 2.75938 GeneID:8027,Genbank:NM_001324284.1,HGNC:HGNC:11357,MIM:601899 signal transducing adaptor molecule GO:0005070,GO:0005829,GO:0006886,GO:0007165,GO:0016197,GO:0016236,GO:0016579,GO:0031901,GO:0033565,GO:0036258,GO:0042059,GO:0044389,GO:0061024,GO:1903543,GO:1903551 SH3/SH2 adaptor activity|cytosol|intracellular protein transport|signal transduction|endosomal transport|macroautophagy|protein deubiquitination|early endosome membrane|ESCRT-0 complex|multivesicular body assembly|negative regulation of epidermal growth factor receptor signaling pathway|ubiquitin-like protein ligase binding|membrane organization|positive regulation of exosomal secretion|regulation of extracellular exosome assembly hsa04144,hsa04630 Endocytosis|Jak-STAT signaling pathway STAM2 290.156090142898 310.833437004786 269.47874328101 0.866955453305563 -0.205970229405931 0.339540627338721 1 2.37407 2.14131 2.26683 1.76272 GeneID:10254,Genbank:NM_005843.5,HGNC:HGNC:11358,MIM:606244 signal transducing adaptor molecule 2 GO:0005654,GO:0005737,GO:0005829,GO:0006886,GO:0016197,GO:0016236,GO:0016579,GO:0031901,GO:0033565,GO:0036258,GO:0042059,GO:0043231,GO:0061024 nucleoplasm|cytoplasm|cytosol|intracellular protein transport|endosomal transport|macroautophagy|protein deubiquitination|early endosome membrane|ESCRT-0 complex|multivesicular body assembly|negative regulation of epidermal growth factor receptor signaling pathway|intracellular membrane-bounded organelle|membrane organization hsa04144,hsa04630 Endocytosis|Jak-STAT signaling pathway STAMBP 1555.1570340609 1438.85160308906 1671.46246503274 1.16166424768495 0.216193151191864 0.132821651209762 1 4.87053 5.09582 6.05535 5.7513 GeneID:10617,Genbank:XM_024452533.1,HGNC:HGNC:16950,MIM:606247 STAM binding protein GO:0000281,GO:0004843,GO:0005634,GO:0005654,GO:0005769,GO:0005829,GO:0005886,GO:0007259,GO:0008237,GO:0008284,GO:0014067,GO:0016579,GO:0019904,GO:0032154,GO:0043524,GO:0046580,GO:0046872,GO:0070062 mitotic cytokinesis|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|early endosome|cytosol|plasma membrane|JAK-STAT cascade|metallopeptidase activity|positive regulation of cell proliferation|negative regulation of phosphatidylinositol 3-kinase signaling|protein deubiquitination|protein domain specific binding|cleavage furrow|negative regulation of neuron apoptotic process|negative regulation of Ras protein signal transduction|metal ion binding|extracellular exosome hsa04144 Endocytosis STAMBPL1 383.176364689925 447.907316727083 318.445412652766 0.710962738853404 -0.492154143875386 0.00833506317563054 0.356525902221039 3.03395 3.17208 2.50971 1.83972 GeneID:57559,Genbank:XM_006717928.2,HGNC:HGNC:24105,MIM:612352 STAM binding protein like 1 GO:0005829,GO:0008237,GO:0016020,GO:0016579,GO:0046872,GO:0061578 cytosol|metallopeptidase activity|membrane|protein deubiquitination|metal ion binding|Lys63-specific deubiquitinase activity STAP2 141.047873964914 145.433502520041 136.662245409786 0.939688882147038 -0.0897449152024932 0.718004039155821 1 2.42606 2.99454 2.7321 2.72612 GeneID:55620,Genbank:XM_011528123.1,HGNC:HGNC:30430,MIM:607881 signal transducing adaptor family member 2 GO:0005829,GO:0005886,GO:0042531 cytosol|plasma membrane|positive regulation of tyrosine phosphorylation of STAT protein STAR 0.97133319677934 0.490071401957362 1.45259499160132 2.96404765876891 1.56756864484914 0.837512515494886 1 0 0.0157587 0 0.0453446 GeneID:6770,Genbank:NM_000349.2,HGNC:HGNC:11359,MIM:600617 steroidogenic acute regulatory protein hsa04913,hsa04925,hsa04927,hsa04934,hsa04979 Ovarian steroidogenesis|Aldosterone synthesis and secretion|Cortisol synthesis and secretion|Cushing syndrome|Cholesterol metabolism STARD10 313.143098215158 282.679870030862 343.606326399454 1.21553164136498 0.281587448484869 0.162097777436225 1 4.33473 5.1287 6.07288 5.51372 GeneID:10809,Genbank:NM_006645.2,HGNC:HGNC:10666,MIM:617382 StAR related lipid transfer domain containing 10 GO:0005829,GO:0005902,GO:0006656,GO:0006869,GO:0008289,GO:0016020,GO:0032782,GO:0035360,GO:0046581 cytosol|microvillus|phosphatidylcholine biosynthetic process|lipid transport|lipid binding|membrane|bile acid secretion|positive regulation of peroxisome proliferator activated receptor signaling pathway|intercellular canaliculus STARD13 467.364526853572 465.597913472233 469.13114023491 1.00758857945975 0.0109066750111509 0.967553580170003 1 1.6839 1.87784 1.94656 1.7132 GeneID:90627,Genbank:NM_001243476.2,HGNC:HGNC:19164,MIM:609866 StAR related lipid transfer domain containing 13 STARD3 1243.75475868519 1258.10658466533 1229.40293270505 0.977185039558544 -0.0332963183881237 0.825074158814445 1 12.1815 12.5726 11.4361 13.4887 GeneID:10948,Genbank:NM_006804.3,HGNC:HGNC:17579,MIM:607048 StAR related lipid transfer domain containing 3 hsa04979 Cholesterol metabolism STARD3NL 2242.83305807218 2378.58833227405 2107.07778387031 0.885852232301097 -0.174862029860853 0.214440597489686 1 42.1063 41.7609 37.3984 39.1671 GeneID:83930,Genbank:NM_032016.3,HGNC:HGNC:19169,MIM:611759 STARD3 N-terminal like GO:0005765,GO:0005829,GO:0006700,GO:0015485,GO:0016020,GO:0016021,GO:0031902,GO:0042803,GO:0043231,GO:0044232,GO:0099044 lysosomal membrane|cytosol|C21-steroid hormone biosynthetic process|cholesterol binding|membrane|integral component of membrane|late endosome membrane|protein homodimerization activity|intracellular membrane-bounded organelle|organelle membrane contact site|vesicle tethering to endoplasmic reticulum STARD4 471.889960646577 501.246630299572 442.533290993582 0.882865368549411 -0.179734642217418 0.471951460639821 1 2.11994 2.00536 2.14765 1.41089 GeneID:134429,Genbank:XM_017009043.2,HGNC:HGNC:18058,MIM:607049 StAR related lipid transfer domain containing 4 GO:0005739,GO:0010873,GO:0010879,GO:0015485,GO:0017127,GO:0031410,GO:0032367,GO:0070508,GO:0070859 mitochondrion|positive regulation of cholesterol esterification|cholesterol transport involved in cholesterol storage|cholesterol binding|cholesterol transporter activity|cytoplasmic vesicle|intracellular cholesterol transport|cholesterol import|positive regulation of bile acid biosynthetic process STARD5 73.8163326794178 73.0000045805763 74.6326607782592 1.02236515198956 0.0319105669954793 0.939247733815733 1 1.92902 1.51654 1.83767 1.91216 GeneID:80765,Genbank:NM_181900.2,HGNC:HGNC:18065,MIM:607050 StAR related lipid transfer domain containing 5 GO:0005739,GO:0005829,GO:0015485,GO:0015721,GO:0017127,GO:0032052,GO:0070508 mitochondrion|cytosol|cholesterol binding|bile acid and bile salt transport|cholesterol transporter activity|bile acid binding|cholesterol import STARD6 1.24168699318059 1.02816907859967 1.45520490776151 1.41533619134263 0.501144783780499 1 1 0.0264375 0.0242834 0.0748318 0 GeneID:147323,Genbank:XM_017025552.2,HGNC:HGNC:18066,MIM:607051 StAR related lipid transfer domain containing 6 GO:0005739,GO:0006869,GO:0015485 mitochondrion|lipid transport|cholesterol binding STARD7 5325.27438668488 5330.73538227586 5319.81339109389 0.997951128615711 -0.00295892885402474 0.979565474115536 1 71.0568 73.6266 75.4568 70.5782 GeneID:56910,Genbank:NM_020151.3,HGNC:HGNC:18063,MIM:616712 StAR related lipid transfer domain containing 7 GO:0005741,GO:0006656,GO:0008289,GO:1903955 mitochondrial outer membrane|phosphatidylcholine biosynthetic process|lipid binding|positive regulation of protein targeting to mitochondrion STARD8 423.928780145849 437.895183279835 409.962377011863 0.936211204565542 -0.0950940635755727 0.589625039306056 1 3.10242 3.48356 2.8452 3.43956 GeneID:9754,Genbank:NM_001142503.2,HGNC:HGNC:19161,MIM:300689 StAR related lipid transfer domain containing 8 GO:0005096,GO:0005829,GO:0005925,GO:0007165,GO:0008289,GO:0051056 GTPase activator activity|cytosol|focal adhesion|signal transduction|lipid binding|regulation of small GTPase mediated signal transduction STARD9 511.64720556875 482.366202343261 540.928208794238 1.12140569999824 0.165308308016827 0.558965963548329 1 0.674334 0.848943 1.11379 0.679879 GeneID:57519,Genbank:XM_011521831.3,HGNC:HGNC:19162,MIM:614642 StAR related lipid transfer domain containing 9 GO:0003777,GO:0005524,GO:0005634,GO:0005737,GO:0005814,GO:0007018,GO:0008017,GO:0015485,GO:0051225 microtubule motor activity|ATP binding|nucleus|cytoplasm|centriole|microtubule-based movement|microtubule binding|cholesterol binding|spindle assembly STAT1 3472.82877754927 2545.87989178087 4399.77766331767 1.72819529999115 0.789266262876171 0.458786164845396 1 20.0468 17.367 52.586 13.7125 GeneID:6772,Genbank:XM_017004783.2,HGNC:HGNC:11362,MIM:600555 signal transducer and activator of transcription 1 hsa04062,hsa04217,hsa04380,hsa04620,hsa04621,hsa04625,hsa04630,hsa04658,hsa04659,hsa04917,hsa04919,hsa04933,hsa05140,hsa05145,hsa05152,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05200,hsa05212,hsa05321 Chemokine signaling pathway|Necroptosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Prolactin signaling pathway|Thyroid hormone signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis|Toxoplasmosis|Tuberculosis|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Pathways in cancer|Pancreatic cancer|Inflammatory bowel disease (IBD) STAT2 1684.61189346405 1291.08443041967 2078.13935650843 1.60960763490342 0.686709053453873 0.173583104741308 1 6.98111 7.53923 15.7401 8.36566 GeneID:6773,Genbank:NM_198332.1,HGNC:HGNC:11363,MIM:600556 signal transducer and activator of transcription 2 hsa04062,hsa04217,hsa04380,hsa04621,hsa04625,hsa04630,hsa05160,hsa05161,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05200 Chemokine signaling pathway|Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|C-type lectin receptor signaling pathway|Jak-STAT signaling pathway|Hepatitis C|Hepatitis B|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Pathways in cancer STAT3 6239.27858946349 5488.12270354162 6990.43447538537 1.27373873599332 0.34906938831578 0.00828391338345156 0.356525902221039 37.2172 37.9025 51.1233 46.2228 GeneID:6774,Genbank:XM_017024973.2,HGNC:HGNC:11364,MIM:102582 signal transducer and activator of transcription 3 GO:0000790,GO:0000978,GO:0000981,GO:0001077,GO:0001103,GO:0001228,GO:0001659,GO:0001754,GO:0003677,GO:0003700,GO:0004879,GO:0005634,GO:0005654,GO:0005737,GO:0005743,GO:0005829,GO:0005886,GO:0006355,GO:0006366,GO:0006606,GO:0006953,GO:0006954,GO:0007259,GO:0007568,GO:0008134,GO:0008283,GO:0008285,GO:0010628,GO:0010730,GO:0016310,GO:0019221,GO:0019827,GO:0019901,GO:0019903,GO:0019953,GO:0030522,GO:0031490,GO:0031730,GO:0032355,GO:0032870,GO:0033210,GO:0035259,GO:0035278,GO:0040014,GO:0042593,GO:0042755,GO:0042789,GO:0042802,GO:0042803,GO:0043066,GO:0043565,GO:0044212,GO:0044320,GO:0044321,GO:0045471,GO:0045648,GO:0045747,GO:0045766,GO:0045820,GO:0045893,GO:0045944,GO:0046902,GO:0046983,GO:0048708,GO:0051726,GO:0060019,GO:0060259,GO:0060396,GO:0060397,GO:0070102,GO:0071345,GO:0071407,GO:0072540,GO:0090575,GO:0097009,GO:1901215,GO:1902728,GO:1902895,GO:1904685,GO:1905564,GO:2000637,GO:2000737,GO:2001171,GO:2001223 nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II repressing transcription factor binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|temperature homeostasis|eye photoreceptor cell differentiation|DNA binding|DNA binding transcription factor activity|nuclear receptor activity|nucleus|nucleoplasm|cytoplasm|mitochondrial inner membrane|cytosol|plasma membrane|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|protein import into nucleus|acute-phase response|inflammatory response|JAK-STAT cascade|aging|transcription factor binding|cell proliferation|negative regulation of cell proliferation|positive regulation of gene expression|negative regulation of hydrogen peroxide biosynthetic process|phosphorylation|cytokine-mediated signaling pathway|stem cell population maintenance|protein kinase binding|protein phosphatase binding|sexual reproduction|intracellular receptor signaling pathway|chromatin DNA binding|CCR5 chemokine receptor binding|response to estradiol|cellular response to hormone stimulus|leptin-mediated signaling pathway|glucocorticoid receptor binding|miRNA mediated inhibition of translation|regulation of multicellular organism growth|glucose homeostasis|eating behavior|mRNA transcription from RNA polymerase II promoter|identical protein binding|protein homodimerization activity|negative regulation of apoptotic process|sequence-specific DNA binding|transcription regulatory region DNA binding|cellular response to leptin stimulus|response to leptin|response to ethanol|positive regulation of erythrocyte differentiation|positive regulation of Notch signaling pathway|positive regulation of angiogenesis|negative regulation of glycolytic process|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of mitochondrial membrane permeability|protein dimerization activity|astrocyte differentiation|regulation of cell cycle|radial glial cell differentiation|regulation of feeding behavior|growth hormone receptor signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|interleukin-6-mediated signaling pathway|cellular response to cytokine stimulus|cellular response to organic cyclic compound|T-helper 17 cell lineage commitment|RNA polymerase II transcription factor complex|energy homeostasis|negative regulation of neuron death|positive regulation of growth factor dependent skeletal muscle satellite cell proliferation|positive regulation of pri-miRNA transcription from RNA polymerase II promoter|positive regulation of metalloendopeptidase activity|positive regulation of vascular endothelial cell proliferation|positive regulation of gene silencing by miRNA|negative regulation of stem cell differentiation|positive regulation of ATP biosynthetic process|negative regulation of neuron migration hsa01521,hsa04062,hsa04066,hsa04068,hsa04217,hsa04550,hsa04630,hsa04659,hsa04917,hsa04920,hsa04931,hsa04933,hsa05145,hsa05160,hsa05161,hsa05162,hsa05163,hsa05167,hsa05169,hsa05200,hsa05203,hsa05205,hsa05206,hsa05212,hsa05221,hsa05223,hsa05321 EGFR tyrosine kinase inhibitor resistance|Chemokine signaling pathway|HIF-1 signaling pathway|FoxO signaling pathway|Necroptosis|Signaling pathways regulating pluripotency of stem cells|Jak-STAT signaling pathway|Th17 cell differentiation|Prolactin signaling pathway|Adipocytokine signaling pathway|Insulin resistance|AGE-RAGE signaling pathway in diabetic complications|Toxoplasmosis|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Pancreatic cancer|Acute myeloid leukemia|Non-small cell lung cancer|Inflammatory bowel disease (IBD) STAT4 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.00935425 0 0 0 GeneID:6775,Genbank:XM_011511705.2,HGNC:HGNC:11365,MIM:600558 signal transducer and activator of transcription 4 hsa04217,hsa04630,hsa04658,hsa05161,hsa05200,hsa05321 Necroptosis|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Hepatitis B|Pathways in cancer|Inflammatory bowel disease (IBD) STAT5A 135.034157325447 146.980151965067 123.088162685826 0.837447512743626 -0.255929322910085 0.341038156191143 1 1.33553 1.14842 0.98176 1.06834 GeneID:6776,Genbank:NM_003152.3,HGNC:HGNC:11366,MIM:601511 signal transducer and activator of transcription 5A hsa04012,hsa04217,hsa04630,hsa04658,hsa04659,hsa04917,hsa04933,hsa05161,hsa05162,hsa05166,hsa05200,hsa05203,hsa05220,hsa05221,hsa05223 ErbB signaling pathway|Necroptosis|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Prolactin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer STAT5B 1586.41409497029 1685.4985460951 1487.32964384547 0.882427129522751 -0.180450948760572 0.202840095168504 1 9.53052 10.011 8.99062 8.49746 GeneID:6777,Genbank:XM_024450897.1,HGNC:HGNC:11367,MIM:604260 signal transducer and activator of transcription 5B hsa04012,hsa04062,hsa04217,hsa04630,hsa04658,hsa04659,hsa04917,hsa04933,hsa05161,hsa05162,hsa05166,hsa05200,hsa05203,hsa05220,hsa05221,hsa05223 ErbB signaling pathway|Chemokine signaling pathway|Necroptosis|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Prolactin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Hepatitis B|Measles|Human T-cell leukemia virus 1 infection|Pathways in cancer|Viral carcinogenesis|Chronic myeloid leukemia|Acute myeloid leukemia|Non-small cell lung cancer STAT6 2.75361941628733 3.084507235799 2.42273159677566 0.785451746929711 -0.348405446488833 0.96056761489562 1 0.0264585 0.00787265 0.0165494 0.00771236 GeneID:6778,Genbank:NM_001178081.1,HGNC:HGNC:11368,MIM:601512 signal transducer and activator of transcription 6 hsa04217,hsa04630,hsa04658,hsa04659,hsa05161,hsa05200,hsa05321 Necroptosis|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Hepatitis B|Pathways in cancer|Inflammatory bowel disease (IBD) STAU1 3260.10474597598 3296.34254295842 3223.86694899354 0.978013330526071 -0.0320739653409498 0.808671012135663 1 23.1138 24.0392 24.6877 21.7539 GeneID:6780,Genbank:NM_001319135.1,HGNC:HGNC:11370,MIM:601716 staufen double-stranded RNA binding protein 1 GO:0003723,GO:0003725,GO:0005737,GO:0005783,GO:0005791,GO:0005829,GO:0005875,GO:0005886,GO:0008157,GO:0010494,GO:0016020,GO:0030425,GO:0034599,GO:0036464,GO:0043025,GO:0044297,GO:0045070,GO:0046726,GO:0070062,GO:1900273 RNA binding|double-stranded RNA binding|cytoplasm|endoplasmic reticulum|rough endoplasmic reticulum|cytosol|microtubule associated complex|plasma membrane|protein phosphatase 1 binding|cytoplasmic stress granule|membrane|dendrite|cellular response to oxidative stress|cytoplasmic ribonucleoprotein granule|neuronal cell body|cell body|positive regulation of viral genome replication|positive regulation by virus of viral protein levels in host cell|extracellular exosome|positive regulation of long-term synaptic potentiation STAU2 527.143840328796 558.006635030654 496.281045626937 0.889381979480717 -0.169124921564241 0.453851413422465 1 3.78834 3.11277 3.36053 2.78183 GeneID:27067,Genbank:NM_001164383.1,HGNC:HGNC:11371,MIM:605920 staufen double-stranded RNA binding protein 2 GO:0003723,GO:0003725,GO:0005730,GO:0005783,GO:0005874,GO:0016020 RNA binding|double-stranded RNA binding|nucleolus|endoplasmic reticulum|microtubule|membrane STBD1 28.0517649861549 22.6677460038776 33.4357839684322 1.47503787816895 0.560752002572678 0.2973817268663 1 4.17908 4.28436 6.13294 4.74627 GeneID:8987,Genbank:NM_003943.4,HGNC:HGNC:24854,MIM:607406 starch binding domain 1 GO:0005622,GO:0005783,GO:0005789,GO:0005829,GO:0005886,GO:0005887,GO:0005980,GO:0016020,GO:0019899,GO:0030247,GO:0030315,GO:0034045,GO:0043312,GO:0046907,GO:0048471,GO:0061723,GO:0070821,GO:0101003,GO:2001069,GO:2001070 intracellular|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|plasma membrane|integral component of plasma membrane|glycogen catabolic process|membrane|enzyme binding|polysaccharide binding|T-tubule|phagophore assembly site membrane|neutrophil degranulation|intracellular transport|perinuclear region of cytoplasm|glycophagy|tertiary granule membrane|ficolin-1-rich granule membrane|glycogen binding|starch binding STC1 1707.71728677743 1418.1245253828 1997.31004817206 1.40841654764621 0.494074082801385 0.00053067410553597 0.0653790498020315 14.531 14.3892 22.6887 18.2893 GeneID:6781,Genbank:NM_003155.2,HGNC:HGNC:11373,MIM:601185 stanniocalcin 1 GO:0001503,GO:0001886,GO:0003421,GO:0005179,GO:0005615,GO:0005634,GO:0005737,GO:0006874,GO:0007566,GO:0010596,GO:0016324,GO:0030336,GO:0033280,GO:0035988,GO:0044070,GO:0046697,GO:0051926,GO:0060348,GO:0071320,GO:0071385,GO:0071456,GO:0086004,GO:0090280,GO:1903403 ossification|endothelial cell morphogenesis|growth plate cartilage axis specification|hormone activity|extracellular space|nucleus|cytoplasm|cellular calcium ion homeostasis|embryo implantation|negative regulation of endothelial cell migration|apical plasma membrane|negative regulation of cell migration|response to vitamin D|chondrocyte proliferation|regulation of anion transport|decidualization|negative regulation of calcium ion transport|bone development|cellular response to cAMP|cellular response to glucocorticoid stimulus|cellular response to hypoxia|regulation of cardiac muscle cell contraction|positive regulation of calcium ion import|negative regulation of renal phosphate excretion STC2 406.473463521246 460.159101776017 352.787825266475 0.766664885916338 -0.383331990528878 0.0360617044470704 0.738653561785664 3.19933 3.38831 2.44762 2.65399 GeneID:8614,Genbank:NM_003714.2,HGNC:HGNC:11374,MIM:603665 stanniocalcin 2 GO:0005179,GO:0005615,GO:0005783,GO:0005788,GO:0005794,GO:0006874,GO:0006979,GO:0007566,GO:0010629,GO:0019899,GO:0020037,GO:0030968,GO:0033280,GO:0040015,GO:0042803,GO:0043434,GO:0043687,GO:0044267,GO:0046697,GO:0046885,GO:0048471,GO:0071456,GO:2001256 hormone activity|extracellular space|endoplasmic reticulum|endoplasmic reticulum lumen|Golgi apparatus|cellular calcium ion homeostasis|response to oxidative stress|embryo implantation|negative regulation of gene expression|enzyme binding|heme binding|endoplasmic reticulum unfolded protein response|response to vitamin D|negative regulation of multicellular organism growth|protein homodimerization activity|response to peptide hormone|post-translational protein modification|cellular protein metabolic process|decidualization|regulation of hormone biosynthetic process|perinuclear region of cytoplasm|cellular response to hypoxia|regulation of store-operated calcium entry STEAP1 117.99924876133 130.82741301069 105.171084511969 0.803891799827728 -0.314926760593423 0.260448541524617 1 4.26139 4.28449 3.77733 3.11649 GeneID:26872,Genbank:NM_012449.2,HGNC:HGNC:11378,MIM:604415 STEAP family member 1 hsa04978 Mineral absorption STEAP1B 8.36744744327924 6.07296192222811 10.6619329643304 1.75563968634577 0.811996787891134 0.458173806486842 1 0.0776024 0.168069 0.195778 0.136253 GeneID:256227,Genbank:NM_207342.2,HGNC:HGNC:41907 STEAP family member 1B GO:0005768,GO:0005887 endosome|integral component of plasma membrane STEAP2 57.3371932561966 53.1089908541722 61.5653956582211 1.15922736749543 0.213163560121245 0.731366299957363 1 0.2587 0.135955 0.32582 0.155434 GeneID:261729,Genbank:NM_001244944.1,HGNC:HGNC:17885,MIM:605094 STEAP2 metalloreductase hsa04978 Mineral absorption STEAP3 1499.79898140464 1609.72180923705 1389.87615357223 0.863426304841441 -0.211855048779901 0.136456764036087 1 11.9167 12.8603 10.6266 10.9909 GeneID:55240,Genbank:XM_006712614.3,HGNC:HGNC:24592,MIM:609671 STEAP3 metalloreductase GO:0005737,GO:0005771,GO:0005887,GO:0006915,GO:0007049,GO:0008823,GO:0009306,GO:0010008,GO:0015677,GO:0016723,GO:0033572,GO:0042802,GO:0042981,GO:0046872,GO:0052851,GO:0055072,GO:0098706 cytoplasm|multivesicular body|integral component of plasma membrane|apoptotic process|cell cycle|cupric reductase activity|protein secretion|endosome membrane|copper ion import|oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor|transferrin transport|identical protein binding|regulation of apoptotic process|metal ion binding|ferric-chelate reductase (NADPH) activity|iron ion homeostasis|ferric iron import across plasma membrane hsa04115,hsa04216 p53 signaling pathway|Ferroptosis STH 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:246744,Genbank:NM_001007532.2,HGNC:HGNC:18839,MIM:607067 saitohin GO:0005634,GO:0005737,GO:0048026,GO:0048471 nucleus|cytoplasm|positive regulation of mRNA splicing, via spliceosome|perinuclear region of cytoplasm STIL 675.062196227952 719.074396138646 631.049996317258 0.877586519150077 -0.188386730614704 0.265239143892161 1 3.85679 3.72026 3.84458 2.74982 GeneID:6491,Genbank:XM_017002123.1,HGNC:HGNC:10879,MIM:181590 STIL, centriolar assembly protein STIM1 1337.28501951494 1183.36680854013 1491.20323048974 1.26013609620281 0.333579554926568 0.0241027072937276 0.621959897532696 9.75215 10.2948 13.3988 12.6557 GeneID:6786,Genbank:NM_001277961.1,HGNC:HGNC:11386,MIM:605921 stromal interaction molecule 1 GO:0002020,GO:0002115,GO:0005246,GO:0005509,GO:0005513,GO:0005783,GO:0005789,GO:0005874,GO:0005886,GO:0005887,GO:0006874,GO:0030176,GO:0032237,GO:0032541,GO:0033017,GO:0042802,GO:0045766,GO:0051010,GO:0051924,GO:0070166,GO:1903779,GO:2001256 protease binding|store-operated calcium entry|calcium channel regulator activity|calcium ion binding|detection of calcium ion|endoplasmic reticulum|endoplasmic reticulum membrane|microtubule|plasma membrane|integral component of plasma membrane|cellular calcium ion homeostasis|integral component of endoplasmic reticulum membrane|activation of store-operated calcium channel activity|cortical endoplasmic reticulum|sarcoplasmic reticulum membrane|identical protein binding|positive regulation of angiogenesis|microtubule plus-end binding|regulation of calcium ion transport|enamel mineralization|regulation of cardiac conduction|regulation of store-operated calcium entry hsa04020,hsa04611 Calcium signaling pathway|Platelet activation STIM2 403.607360506034 433.531549936049 373.683171076019 0.861951503024733 -0.214321395310783 0.257245224100079 1 3.22413 2.91213 2.90079 2.34607 GeneID:57620,Genbank:NM_001169118.1,HGNC:HGNC:19205,MIM:610841 stromal interaction molecule 2 GO:0002115,GO:0005246,GO:0005509,GO:0005783,GO:0005789,GO:0005886,GO:0006874,GO:0015279,GO:0016021,GO:0032237,GO:0051928 store-operated calcium entry|calcium channel regulator activity|calcium ion binding|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|cellular calcium ion homeostasis|store-operated calcium channel activity|integral component of membrane|activation of store-operated calcium channel activity|positive regulation of calcium ion transport hsa04020 Calcium signaling pathway STIMATE 656.837175043954 653.11870462996 660.555645457949 1.0113868134158 0.0163348736671636 0.930185710297241 1 8.64579 8.6198 8.87759 8.40049 GeneID:375346,Genbank:NM_198563.2,HGNC:HGNC:30526,MIM:617189 STIM activating enhancer GO:0005246,GO:0005789,GO:0016021,GO:0032237,GO:0032541,GO:0035584,GO:0051533 calcium channel regulator activity|endoplasmic reticulum membrane|integral component of membrane|activation of store-operated calcium channel activity|cortical endoplasmic reticulum|calcium-mediated signaling using intracellular calcium source|positive regulation of NFAT protein import into nucleus STIP1 8574.52849567063 8904.75427104365 8244.3027202976 0.925831580452063 -0.111178320565486 0.386354480772657 1 89.878 95.1149 86.6058 87.0092 GeneID:10963,Genbank:NM_001282652.1,HGNC:HGNC:11387,MIM:605063 stress induced phosphoprotein 1 GO:0003723,GO:0005634,GO:0005794,GO:0005829,GO:0006950,GO:0008022,GO:0030544,GO:0043209,GO:0043234,GO:0051087 RNA binding|nucleus|Golgi apparatus|cytosol|response to stress|protein C-terminus binding|Hsp70 protein binding|myelin sheath|protein complex|chaperone binding hsa05020 Prion diseases STK10 1548.53239429603 1448.81774426333 1648.24704432872 1.13764968082082 0.186056373505978 0.205688603346723 1 7.6563 8.20413 9.68814 8.83263 GeneID:6793,Genbank:NM_005990.3,HGNC:HGNC:11388,MIM:603919 serine/threonine kinase 10 GO:0004674,GO:0005524,GO:0005737,GO:0005886,GO:0006468,GO:0007049,GO:0007346,GO:0023014,GO:0031098,GO:0032147,GO:0035579,GO:0042802,GO:0042803,GO:0042981,GO:0043312,GO:0046777,GO:0070062,GO:0071593,GO:2000401 protein serine/threonine kinase activity|ATP binding|cytoplasm|plasma membrane|protein phosphorylation|cell cycle|regulation of mitotic cell cycle|signal transduction by protein phosphorylation|stress-activated protein kinase signaling cascade|activation of protein kinase activity|specific granule membrane|identical protein binding|protein homodimerization activity|regulation of apoptotic process|neutrophil degranulation|protein autophosphorylation|extracellular exosome|lymphocyte aggregation|regulation of lymphocyte migration hsa04914 Progesterone-mediated oocyte maturation STK11 2136.41021718251 2091.96355006648 2180.85688429855 1.042492773944 0.060037383639934 0.695057918644441 1 21.5985 23.3783 24.437 23.8549 GeneID:6794,Genbank:NM_000455.4,HGNC:HGNC:11389,MIM:602216 serine/threonine kinase 11 hsa04068,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04530,hsa04920 FoxO signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Tight junction|Adipocytokine signaling pathway STK11IP 386.877800455314 383.622736177261 390.132864733366 1.01697013222151 0.0242773087640757 0.904735422901649 1 3.17681 3.06565 3.2726 3.02758 GeneID:114790,Genbank:NM_052902.3,HGNC:HGNC:19184,MIM:607172 serine/threonine kinase 11 interacting protein GO:0005576,GO:0005737,GO:0005765,GO:0008104,GO:0019901,GO:0035578,GO:0043312 extracellular region|cytoplasm|lysosomal membrane|protein localization|protein kinase binding|azurophil granule lumen|neutrophil degranulation STK16 605.903509471889 566.800528302273 645.006490641505 1.13797792774379 0.186472575356801 0.268879534517437 1 6.29042 6.69287 7.29413 7.94705 GeneID:8576,Genbank:NM_001330213.1,HGNC:HGNC:11394,MIM:604719 serine/threonine kinase 16 GO:0001077,GO:0004674,GO:0004715,GO:0005524,GO:0005737,GO:0005798,GO:0005829,GO:0016020,GO:0046777,GO:0048471,GO:0071560 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|protein serine/threonine kinase activity|non-membrane spanning protein tyrosine kinase activity|ATP binding|cytoplasm|Golgi-associated vesicle|cytosol|membrane|protein autophosphorylation|perinuclear region of cytoplasm|cellular response to transforming growth factor beta stimulus STK17A 5761.58850243121 5492.46265157177 6030.71435329066 1.09799824520698 0.134875748666231 0.302342284734809 1 54.011 55.5215 61.1131 59.0534 GeneID:9263,Genbank:NM_004760.2,HGNC:HGNC:11395,MIM:604726 serine/threonine kinase 17a GO:0004674,GO:0005524,GO:0005634,GO:0005886,GO:0006468,GO:0006915,GO:0016607,GO:0035556,GO:0043065,GO:2000271,GO:2000377 protein serine/threonine kinase activity|ATP binding|nucleus|plasma membrane|protein phosphorylation|apoptotic process|nuclear speck|intracellular signal transduction|positive regulation of apoptotic process|positive regulation of fibroblast apoptotic process|regulation of reactive oxygen species metabolic process STK17B 274.470968966264 317.752271561982 231.189666370546 0.727578327714487 -0.458825524636412 0.0265966459853692 0.653331107517903 2.0966 1.96651 1.84592 1.38851 GeneID:9262,Genbank:NM_004226.3,HGNC:HGNC:11396,MIM:604727 serine/threonine kinase 17b GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005793,GO:0005886,GO:0006468,GO:0006915,GO:0015629,GO:0035556,GO:0046777,GO:2000271 protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|endoplasmic reticulum-Golgi intermediate compartment|plasma membrane|protein phosphorylation|apoptotic process|actin cytoskeleton|intracellular signal transduction|protein autophosphorylation|positive regulation of fibroblast apoptotic process STK19 240.114381501032 236.469079422815 243.75968357925 1.0308311098188 0.0438079825740799 0.82408626499243 1 4.51933 3.63825 4.48939 4.35375 GeneID:8859,Genbank:NM_032454.1,HGNC:HGNC:11398,MIM:604977 serine/threonine kinase 19 GO:0004674,GO:0005524,GO:0005634,GO:0006468,GO:0016607 protein serine/threonine kinase activity|ATP binding|nucleus|protein phosphorylation|nuclear speck STK24 2347.63644612739 2249.74183918226 2445.53105307252 1.08702741375936 0.120388324170168 0.387736880135106 1 14.631 14.9299 17.5083 15.0767 GeneID:8428,Genbank:NM_001286649.1,HGNC:HGNC:11403,MIM:604984 serine/threonine kinase 24 GO:0004674,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0006468,GO:0007346,GO:0008349,GO:0008631,GO:0009267,GO:0016020,GO:0030336,GO:0031098,GO:0042542,GO:0042981,GO:0045296,GO:0046777,GO:0046872,GO:0048679,GO:0048812,GO:0097194 protein serine/threonine kinase activity|ATP binding|nucleus|nucleolus|cytoplasm|cytosol|protein phosphorylation|regulation of mitotic cell cycle|MAP kinase kinase kinase kinase activity|intrinsic apoptotic signaling pathway in response to oxidative stress|cellular response to starvation|membrane|negative regulation of cell migration|stress-activated protein kinase signaling cascade|response to hydrogen peroxide|regulation of apoptotic process|cadherin binding|protein autophosphorylation|metal ion binding|regulation of axon regeneration|neuron projection morphogenesis|execution phase of apoptosis STK25 1776.55349652792 1647.59056035586 1905.51643269998 1.15654731129827 0.209824284027964 0.144482233863399 1 13.1989 13.4507 15.7071 15.7835 GeneID:10494,Genbank:NM_001282305.1,HGNC:HGNC:11404,MIM:602255 serine/threonine kinase 25 STK26 779.046791750708 884.426304348706 673.667279152711 0.761699732177008 -0.392705706450014 0.0286572257026991 0.672982590695644 10.9454 9.34775 8.69491 7.11447 GeneID:51765,Genbank:NM_016542.3,HGNC:HGNC:18174,MIM:300547 serine/threonine kinase 26 GO:0000139,GO:0000287,GO:0004672,GO:0005524,GO:0005737,GO:0005794,GO:0005798,GO:0005829,GO:0006468,GO:0007346,GO:0008349,GO:0009267,GO:0012506,GO:0016020,GO:0016324,GO:0030033,GO:0030336,GO:0031098,GO:0042542,GO:0042802,GO:0042803,GO:0042981,GO:0046777,GO:0048471,GO:0048812,GO:0070062,GO:0071944,GO:0097194,GO:1903205 Golgi membrane|magnesium ion binding|protein kinase activity|ATP binding|cytoplasm|Golgi apparatus|Golgi-associated vesicle|cytosol|protein phosphorylation|regulation of mitotic cell cycle|MAP kinase kinase kinase kinase activity|cellular response to starvation|vesicle membrane|membrane|apical plasma membrane|microvillus assembly|negative regulation of cell migration|stress-activated protein kinase signaling cascade|response to hydrogen peroxide|identical protein binding|protein homodimerization activity|regulation of apoptotic process|protein autophosphorylation|perinuclear region of cytoplasm|neuron projection morphogenesis|extracellular exosome|cell periphery|execution phase of apoptosis|regulation of hydrogen peroxide-induced cell death STK3 309.052653944827 332.636710064335 285.468597825319 0.858199318319699 -0.220615339754432 0.274251176974817 1 1.21339 1.08467 1.05393 0.850668 GeneID:6788,Genbank:XM_024447238.1,HGNC:HGNC:11406,MIM:605030 serine/threonine kinase 3 GO:0000287,GO:0001841,GO:0003157,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0006915,GO:0007165,GO:0007346,GO:0007417,GO:0008285,GO:0023014,GO:0031098,GO:0032092,GO:0035329,GO:0035556,GO:0042802,GO:0042981,GO:0043065,GO:0043234,GO:0043539,GO:0045600,GO:0046330,GO:0046621,GO:0046983,GO:0050821,GO:0051091,GO:0051897,GO:0060215,GO:0060706,GO:0060800,GO:0090090,GO:0097284,GO:1902043 magnesium ion binding|neural tube formation|endocardium development|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|apoptotic process|signal transduction|regulation of mitotic cell cycle|central nervous system development|negative regulation of cell proliferation|signal transduction by protein phosphorylation|stress-activated protein kinase signaling cascade|positive regulation of protein binding|hippo signaling|intracellular signal transduction|identical protein binding|regulation of apoptotic process|positive regulation of apoptotic process|protein complex|protein serine/threonine kinase activator activity|positive regulation of fat cell differentiation|positive regulation of JNK cascade|negative regulation of organ growth|protein dimerization activity|protein stabilization|positive regulation of DNA binding transcription factor activity|positive regulation of protein kinase B signaling|primitive hemopoiesis|cell differentiation involved in embryonic placenta development|regulation of cell differentiation involved in embryonic placenta development|negative regulation of canonical Wnt signaling pathway|hepatocyte apoptotic process|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors hsa04010,hsa04390,hsa04392 MAPK signaling pathway|Hippo signaling pathway|Hippo signaling pathway - multiple species STK31 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0102972 0 GeneID:56164,Genbank:XM_011515452.3,HGNC:HGNC:11407,MIM:605790 serine/threonine kinase 31 GO:0001669,GO:0004518,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006401 acrosomal vesicle|nuclease activity|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|RNA catabolic process STK32A 345.874033250628 309.863102855979 381.884963645278 1.23243122567831 0.301507141011924 0.110444931807273 1 1.26638 1.0384 1.6834 1.39871 GeneID:202374,Genbank:XM_011537577.2,HGNC:HGNC:28317 serine/threonine kinase 32A GO:0004674,GO:0005524,GO:0005622,GO:0005886,GO:0018105,GO:0035556,GO:0046872 protein serine/threonine kinase activity|ATP binding|intracellular|plasma membrane|peptidyl-serine phosphorylation|intracellular signal transduction|metal ion binding STK32B 2.97757851563533 4.01662376502878 1.93853326624189 0.482627544835033 -1.05101783854861 0.613619425049612 1 0.0104446 0.0240985 0.00992761 0.00923768 GeneID:55351,Genbank:NM_001306082.1,HGNC:HGNC:14217 serine/threonine kinase 32B GO:0004674,GO:0005524,GO:0005622,GO:0018105,GO:0035556,GO:0046872 protein serine/threonine kinase activity|ATP binding|intracellular|peptidyl-serine phosphorylation|intracellular signal transduction|metal ion binding STK32C 260.349932450664 256.601241523499 264.098623377828 1.02921802642035 0.0415486307419681 0.921331424498405 1 1.26153 1.71384 1.48464 1.70014 GeneID:282974,Genbank:NM_001318878.1,HGNC:HGNC:21332 serine/threonine kinase 32C GO:0004674,GO:0005524,GO:0005622,GO:0018105,GO:0035556,GO:0046872 protein serine/threonine kinase activity|ATP binding|intracellular|peptidyl-serine phosphorylation|intracellular signal transduction|metal ion binding STK33 123.496400361205 147.172257063807 99.8205436586028 0.678256525041436 -0.560097073132687 0.0421758126894681 0.765859201853198 0.548635 0.473117 0.308003 0.40193 GeneID:65975,Genbank:NM_001289059.1,HGNC:HGNC:14568,MIM:607670 serine/threonine kinase 33 GO:0004674,GO:0005524,GO:0005622,GO:0018105,GO:0018107,GO:0035556,GO:0046777,GO:0048471 protein serine/threonine kinase activity|ATP binding|intracellular|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|intracellular signal transduction|protein autophosphorylation|perinuclear region of cytoplasm STK35 618.703975635629 600.115574980265 637.292376290993 1.06194940251626 0.0867150293456026 0.622008952132233 1 2.22453 2.5463 2.63137 2.47517 GeneID:140901,Genbank:XM_011529174.3,HGNC:HGNC:16254,MIM:609370 serine/threonine kinase 35 GO:0004674,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0016604 protein serine/threonine kinase activity|ATP binding|nucleus|nucleolus|cytoplasm|nuclear body STK36 475.987897283408 474.621112461313 477.354682105504 1.00575947755466 0.00828533294906614 0.989009294979239 1 3.12075 3.53397 3.35099 3.34741 GeneID:27148,Genbank:NM_015690.4,HGNC:HGNC:17209,MIM:607652 serine/threonine kinase 36 GO:0003351,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006468,GO:0007228,GO:0007420,GO:0008134,GO:0009791,GO:0045880,GO:0046872,GO:0051090,GO:0060271 epithelial cilium movement|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|protein phosphorylation|positive regulation of hh target transcription factor activity|brain development|transcription factor binding|post-embryonic development|positive regulation of smoothened signaling pathway|metal ion binding|regulation of DNA binding transcription factor activity|cilium assembly STK38 1287.9335559866 1245.98805278449 1329.87905918871 1.06732890112128 0.0940048161802096 0.522504360599723 1 11.0741 11.2344 12.7755 10.8938 GeneID:11329,Genbank:NM_001305102.1,HGNC:HGNC:17847,MIM:606964 serine/threonine kinase 38 GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0018105,GO:0031435,GO:0035556,GO:0043407,GO:0045296 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|cytosol|cellular protein modification process|protein phosphorylation|peptidyl-serine phosphorylation|mitogen-activated protein kinase kinase kinase binding|intracellular signal transduction|negative regulation of MAP kinase activity|cadherin binding STK38L 257.149820157536 276.797996206519 237.501644108553 0.858032382327483 -0.220895998512552 0.484540973269458 1 1.7157 1.24171 1.47486 0.983185 GeneID:23012,Genbank:NM_015000.3,HGNC:HGNC:17848,MIM:615836 serine/threonine kinase 38 like GO:0000287,GO:0003779,GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0015629,GO:0016020,GO:0018105,GO:0035556,GO:0051128 magnesium ion binding|actin binding|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|actin cytoskeleton|membrane|peptidyl-serine phosphorylation|intracellular signal transduction|regulation of cellular component organization STK39 535.321447337164 521.012165511282 549.630729163046 1.05492878198665 0.0771456061904933 0.708874595959179 1 1.501 1.18233 1.65584 1.27845 GeneID:27347,Genbank:NM_013233.2,HGNC:HGNC:17717,MIM:607648 serine/threonine kinase 39 GO:0001933,GO:0004674,GO:0004702,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0006950,GO:0007346,GO:0008217,GO:0016301,GO:0016323,GO:0016324,GO:0018105,GO:0018107,GO:0019898,GO:0019901,GO:0023014,GO:0023016,GO:0031098,GO:0032147,GO:0032414,GO:0035556,GO:0036438,GO:0042981,GO:0043231,GO:0043268,GO:0046777,GO:0050727,GO:0071476,GO:0090188,GO:1901017,GO:1901380,GO:1905408,GO:2000021,GO:2000650,GO:2000681,GO:2000687 negative regulation of protein phosphorylation|protein serine/threonine kinase activity|signal transducer, downstream of receptor, with serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|response to stress|regulation of mitotic cell cycle|regulation of blood pressure|kinase activity|basolateral plasma membrane|apical plasma membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|extrinsic component of membrane|protein kinase binding|signal transduction by protein phosphorylation|signal transduction by trans-phosphorylation|stress-activated protein kinase signaling cascade|activation of protein kinase activity|positive regulation of ion transmembrane transporter activity|intracellular signal transduction|maintenance of lens transparency|regulation of apoptotic process|intracellular membrane-bounded organelle|positive regulation of potassium ion transport|protein autophosphorylation|regulation of inflammatory response|cellular hypotonic response|negative regulation of pancreatic juice secretion|negative regulation of potassium ion transmembrane transporter activity|negative regulation of potassium ion transmembrane transport|negative regulation of creatine transmembrane transporter activity|regulation of ion homeostasis|negative regulation of sodium ion transmembrane transporter activity|negative regulation of rubidium ion transport|negative regulation of rubidium ion transmembrane transporter activity STK4 1245.19907227403 1358.24077879548 1132.15736575257 0.833546881692503 -0.262664751004763 0.0777079162323851 0.94157495521624 5.71221 5.68983 5.13358 4.3728 GeneID:6789,Genbank:NM_001352385.1,HGNC:HGNC:11408,MIM:604965 serine/threonine kinase 4 hsa04010,hsa04014,hsa04068,hsa05200,hsa05223 MAPK signaling pathway|Ras signaling pathway|FoxO signaling pathway|Pathways in cancer|Non-small cell lung cancer STK40 1028.90798420577 906.807926706183 1151.00804170536 1.26929640534373 0.344029005811429 0.0244379498151733 0.624239560191094 9.20914 9.34159 12.8547 11.9599 GeneID:83931,Genbank:NM_001282547.1,HGNC:HGNC:21373,MIM:609437 serine/threonine kinase 40 GO:0003016,GO:0004674,GO:0005524,GO:0005654,GO:0005829,GO:0005977,GO:0010468,GO:0035264,GO:0043066,GO:0043408,GO:0048286,GO:0060425 respiratory system process|protein serine/threonine kinase activity|ATP binding|nucleoplasm|cytosol|glycogen metabolic process|regulation of gene expression|multicellular organism growth|negative regulation of apoptotic process|regulation of MAPK cascade|lung alveolus development|lung morphogenesis STKLD1 3.71744796401138 2.10436443188427 5.33053149613849 2.53308382111622 1.34089481740094 0.436546354847813 1 0.031869 0.0141034 0.0297746 0 GeneID:169436,Genbank:NM_153710.4,HGNC:HGNC:28669 serine/threonine kinase like domain containing 1 GO:0004674,GO:0005524 protein serine/threonine kinase activity|ATP binding STMN1 13088.1249002566 12985.9090772353 13190.3407232778 1.01574257488071 0.0225348184484714 0.857452535773441 1 135.016 131.202 138.54 136.628 GeneID:3925,Genbank:NM_001145454.2,HGNC:HGNC:6510,MIM:151442 stathmin 1 GO:0000281,GO:0005737,GO:0005829,GO:0005874,GO:0007019,GO:0007052,GO:0007409,GO:0007420,GO:0009615,GO:0015631,GO:0016020,GO:0031110,GO:0031115,GO:0031175,GO:0035024,GO:0035556,GO:0043005,GO:0048012,GO:0051272,GO:0051493,GO:0051497,GO:0061436,GO:0070062,GO:0070495,GO:1905098 mitotic cytokinesis|cytoplasm|cytosol|microtubule|microtubule depolymerization|mitotic spindle organization|axonogenesis|brain development|response to virus|tubulin binding|membrane|regulation of microtubule polymerization or depolymerization|negative regulation of microtubule polymerization|neuron projection development|negative regulation of Rho protein signal transduction|intracellular signal transduction|neuron projection|hepatocyte growth factor receptor signaling pathway|positive regulation of cellular component movement|regulation of cytoskeleton organization|negative regulation of stress fiber assembly|establishment of skin barrier|extracellular exosome|negative regulation of thrombin-activated receptor signaling pathway|negative regulation of guanyl-nucleotide exchange factor activity hsa04010,hsa05206 MAPK signaling pathway|MicroRNAs in cancer STMN2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.017481 0 0 GeneID:11075,Genbank:NM_001199214.1,HGNC:HGNC:10577,MIM:600621 stathmin 2 GO:0005737,GO:0005768,GO:0005794,GO:0007019,GO:0007026,GO:0010976,GO:0010977,GO:0015631,GO:0016020,GO:0030027,GO:0030424,GO:0030426,GO:0031115,GO:0031117,GO:0031175,GO:0043005,GO:0043025,GO:0048306,GO:0048471,GO:0051493,GO:1990090 cytoplasm|endosome|Golgi apparatus|microtubule depolymerization|negative regulation of microtubule depolymerization|positive regulation of neuron projection development|negative regulation of neuron projection development|tubulin binding|membrane|lamellipodium|axon|growth cone|negative regulation of microtubule polymerization|positive regulation of microtubule depolymerization|neuron projection development|neuron projection|neuronal cell body|calcium-dependent protein binding|perinuclear region of cytoplasm|regulation of cytoskeleton organization|cellular response to nerve growth factor stimulus STMN3 271.300825177112 330.369666499034 212.23198385519 0.642407597841041 -0.638439138982991 0.0105777871119607 0.413204483866249 5.44224 5.6115 2.73058 4.31345 GeneID:50861,Genbank:NM_015894.3,HGNC:HGNC:15926,MIM:608362 stathmin 3 GO:0005737,GO:0005794,GO:0007019,GO:0007399,GO:0015631,GO:0019904,GO:0030424,GO:0030426,GO:0031110,GO:0031122,GO:0031175,GO:0035021,GO:0043005,GO:0043087,GO:0051493 cytoplasm|Golgi apparatus|microtubule depolymerization|nervous system development|tubulin binding|protein domain specific binding|axon|growth cone|regulation of microtubule polymerization or depolymerization|cytoplasmic microtubule organization|neuron projection development|negative regulation of Rac protein signal transduction|neuron projection|regulation of GTPase activity|regulation of cytoskeleton organization STMN4 0.974269732491135 0.980142803914724 0.968396661067546 0.988015886256305 -0.0173938558720137 1 1 0 0 0 0.0100725 GeneID:81551,Genbank:NM_001283055.1,HGNC:HGNC:16078 stathmin 4 GO:0005737,GO:0005794,GO:0007019,GO:0015631,GO:0030424,GO:0030426,GO:0031110,GO:0031175,GO:0043005,GO:0051493 cytoplasm|Golgi apparatus|microtubule depolymerization|tubulin binding|axon|growth cone|regulation of microtubule polymerization or depolymerization|neuron projection development|neuron projection|regulation of cytoskeleton organization STMND1 1.24331857081229 1.51824048055703 0.968396661067546 0.63784141805536 -0.648730313253623 0.974450815829398 1 0.0269295 0 0 0.0480545 GeneID:401236,Genbank:NM_001190766.1,HGNC:HGNC:44668 stathmin domain containing 1 GO:0031110 regulation of microtubule polymerization or depolymerization STMP1 2156.49526401325 2163.60392529649 2149.38660273001 0.99342887004398 -0.00951142133138944 0.967130112522501 1 52.2417 50.146 54.2015 48.5517 GeneID:647087,Genbank:NM_001130929.1,HGNC:HGNC:41909 short transmembrane mitochondrial protein 1 GO:0016021,GO:0031966 integral component of membrane|mitochondrial membrane STN1 933.813814671356 865.891868970298 1001.73576037241 1.1568832047859 0.210243221937631 0.171557396568443 1 4.664 4.31242 5.59601 5.20747 GeneID:79991,Genbank:NM_024928.4,HGNC:HGNC:26200,MIM:613128 STN1, CST complex subunit GO:0000723,GO:0000784,GO:0001650,GO:0003697,GO:0005634,GO:0005654,GO:0010833,GO:0016233,GO:0032211,GO:0042162,GO:0043047,GO:0043231,GO:0045111,GO:0045740,GO:1990879 telomere maintenance|nuclear chromosome, telomeric region|fibrillar center|single-stranded DNA binding|nucleus|nucleoplasm|telomere maintenance via telomere lengthening|telomere capping|negative regulation of telomere maintenance via telomerase|telomeric DNA binding|single-stranded telomeric DNA binding|intracellular membrane-bounded organelle|intermediate filament cytoskeleton|positive regulation of DNA replication|CST complex STOM 1342.97617794032 1223.32030678061 1462.63204910004 1.19562476073762 0.257764679866579 0.078256380848228 0.941663557975371 18.1168 18.3936 22.8042 21.2897 GeneID:2040,Genbank:NM_198194.2,HGNC:HGNC:3383,MIM:133090 stomatin GO:0005615,GO:0005739,GO:0005783,GO:0005856,GO:0005886,GO:0005887,GO:0016020,GO:0031982,GO:0035577,GO:0035579,GO:0042470,GO:0042803,GO:0043312,GO:0044829,GO:0045121,GO:0048471,GO:0051260,GO:0070062,GO:0070063,GO:0070821,GO:0072562,GO:0090314,GO:1901585 extracellular space|mitochondrion|endoplasmic reticulum|cytoskeleton|plasma membrane|integral component of plasma membrane|membrane|vesicle|azurophil granule membrane|specific granule membrane|melanosome|protein homodimerization activity|neutrophil degranulation|positive regulation by host of viral genome replication|membrane raft|perinuclear region of cytoplasm|protein homooligomerization|extracellular exosome|RNA polymerase binding|tertiary granule membrane|blood microparticle|positive regulation of protein targeting to membrane|regulation of acid-sensing ion channel activity STOML1 498.928298403407 485.614405713331 512.242191093484 1.05483318671537 0.0770148664900424 0.70143066427487 1 3.95792 4.86351 4.78469 4.9833 GeneID:9399,Genbank:NM_001256676.1,HGNC:HGNC:14560,MIM:608326 stomatin like 1 GO:0005886,GO:0006869,GO:0016021,GO:0031902,GO:0045121 plasma membrane|lipid transport|integral component of membrane|late endosome membrane|membrane raft STOML2 2402.18374901863 2546.70142345478 2257.66607458247 0.88650599312101 -0.173797710557833 0.28937390204584 1 64.1507 65.8838 53.1461 64.1768 GeneID:30968,Genbank:NM_001287032.1,HGNC:HGNC:14559,MIM:608292 stomatin like 2 STOML3 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0 0 GeneID:161003,Genbank:NM_145286.2,HGNC:HGNC:19420,MIM:608327 stomatin like 3 GO:0005886,GO:0005929,GO:0007165,GO:0016021,GO:0034220,GO:0045121 plasma membrane|cilium|signal transduction|integral component of membrane|ion transmembrane transport|membrane raft STON1 93.8644193193884 78.6789476502169 109.04989098856 1.38601105181736 0.470938761326876 0.121908495793601 1 0.909554 0.953592 1.54628 1.09183 GeneID:11037,Genbank:NM_001198595.1,HGNC:HGNC:17003,MIM:605357 stonin 1 GO:0005737,GO:0006897,GO:0016020,GO:0030100 cytoplasm|endocytosis|membrane|regulation of endocytosis STON1-GTF2A1L 226.959514452412 232.952335714852 220.966693189973 0.948548948916529 -0.0762058704999455 0.748981465632688 1 0.526324 0.57165 0.479658 0.520025 GeneID:286749,Genbank:NM_001198593.1,HGNC:HGNC:30651 STON1-GTF2A1L readthrough GO:0005737,GO:0006897,GO:0016020,GO:0030100 cytoplasm|endocytosis|membrane|regulation of endocytosis STON2 342.50478122471 333.578635248672 351.430927200747 1.05351749202633 0.075214268070872 0.828863899539322 1 0.859134 0.842434 1.15305 0.666655 GeneID:85439,Genbank:NM_001256430.1,HGNC:HGNC:30652,MIM:608467 stonin 2 GO:0002244,GO:0005730,GO:0005829,GO:0008021,GO:0016020,GO:0030054,GO:0030100,GO:0030136,GO:0043005,GO:0048488,GO:0061024 hematopoietic progenitor cell differentiation|nucleolus|cytosol|synaptic vesicle|membrane|cell junction|regulation of endocytosis|clathrin-coated vesicle|neuron projection|synaptic vesicle endocytosis|membrane organization STOX1 28.9225987928908 26.3383771910039 31.5068203947777 1.19623240894049 0.2584977094796 0.633248707128307 1 0.180849 0.133202 0.238043 0.137736 GeneID:219736,Genbank:NM_001130161.2,HGNC:HGNC:23508,MIM:609397 storkhead box 1 GO:0000977,GO:0001650,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005829,GO:0005938,GO:0006351,GO:0007049,GO:0008284,GO:0010468,GO:0010628,GO:0010629,GO:0010800,GO:0010821,GO:0010971,GO:0033138,GO:0048839,GO:0050679,GO:0051301,GO:0051881,GO:0051897,GO:0061418,GO:0071500,GO:1901858,GO:1902882,GO:1904031,GO:1904120 RNA polymerase II regulatory region sequence-specific DNA binding|fibrillar center|nucleus|nucleoplasm|cytoplasm|centrosome|cytosol|cell cortex|transcription, DNA-templated|cell cycle|positive regulation of cell proliferation|regulation of gene expression|positive regulation of gene expression|negative regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|regulation of mitochondrion organization|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of peptidyl-serine phosphorylation|inner ear development|positive regulation of epithelial cell proliferation|cell division|regulation of mitochondrial membrane potential|positive regulation of protein kinase B signaling|regulation of transcription from RNA polymerase II promoter in response to hypoxia|cellular response to nitrosative stress|regulation of mitochondrial DNA metabolic process|regulation of response to oxidative stress|positive regulation of cyclin-dependent protein kinase activity|positive regulation of otic vesicle morphogenesis STOX2 58.8834458225482 47.9779541162818 69.7889375288147 1.45460428261844 0.540626728974099 0.145930066217921 1 0.103924 0.0944389 0.157196 0.140496 GeneID:56977,Genbank:XM_011532130.1,HGNC:HGNC:25450,MIM:617359 storkhead box 2 GO:0001893,GO:0009790 maternal placenta development|embryo development STPG1 342.443135933049 321.904182496812 362.982089369286 1.12760911198437 0.173267041199008 0.386481882410773 1 2.72591 3.03983 3.35368 3.18836 GeneID:90529,Genbank:XM_011542403.2,HGNC:HGNC:28070,MIM:615826 sperm tail PG-rich repeat containing 1 GO:0005622,GO:0005634,GO:0005739,GO:0043065,GO:0090073,GO:1902110 intracellular|nucleus|mitochondrion|positive regulation of apoptotic process|positive regulation of protein homodimerization activity|positive regulation of mitochondrial membrane permeability involved in apoptotic process STPG3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:441476,Genbank:XM_006717113.2,HGNC:HGNC:37285 sperm-tail PG-rich repeat containing 3 STPG4 0.807146514963456 1.61429302992691 0 0 -Inf 0.549240155942477 1 0.0455367 0 0 0 GeneID:285051,Genbank:NM_001163561.1,HGNC:HGNC:26850 sperm-tail PG-rich repeat containing 4 GO:0001939,GO:0001940,GO:0003682,GO:0005634,GO:0005737,GO:0016569,GO:0042585,GO:0044727,GO:1901537 female pronucleus|male pronucleus|chromatin binding|nucleus|cytoplasm|covalent chromatin modification|germinal vesicle|DNA demethylation of male pronucleus|positive regulation of DNA demethylation STRA6 460.990312343678 583.280659525191 338.699965162165 0.580680946009555 -0.784182399487231 0.00140896018341614 0.127490996031598 2.24336 2.70288 1.2201 1.75849 GeneID:64220,Genbank:XM_017022479.1,HGNC:HGNC:30650,MIM:610745 stimulated by retinoic acid 6 GO:0001523,GO:0001568,GO:0001822,GO:0003184,GO:0003281,GO:0004872,GO:0005886,GO:0005887,GO:0007507,GO:0007612,GO:0007631,GO:0016918,GO:0019841,GO:0030324,GO:0030325,GO:0030540,GO:0034632,GO:0034633,GO:0042297,GO:0043010,GO:0043234,GO:0043583,GO:0043585,GO:0048286,GO:0048520,GO:0048546,GO:0048566,GO:0048589,GO:0048745,GO:0048844,GO:0050890,GO:0050905,GO:0060322,GO:0060323,GO:0060325,GO:0060426,GO:0060539,GO:0060900,GO:0061029,GO:0061038,GO:0061143,GO:0061156,GO:0061205,GO:0097070 retinoid metabolic process|blood vessel development|kidney development|pulmonary valve morphogenesis|ventricular septum development|receptor activity|plasma membrane|integral component of plasma membrane|heart development|learning|feeding behavior|retinal binding|retinol binding|lung development|adrenal gland development|female genitalia development|retinol transmembrane transporter activity|retinol transport|vocal learning|camera-type eye development|protein complex|ear development|nose morphogenesis|lung alveolus development|positive regulation of behavior|digestive tract morphogenesis|embryonic digestive tract development|developmental growth|smooth muscle tissue development|artery morphogenesis|cognition|neuromuscular process|head development|head morphogenesis|face morphogenesis|lung vasculature development|diaphragm development|embryonic camera-type eye formation|eyelid development in camera-type eye|uterus morphogenesis|alveolar primary septum development|pulmonary artery morphogenesis|paramesonephric duct development|ductus arteriosus closure STRA8 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0125607 GeneID:346673,Genbank:NM_182489.1,HGNC:HGNC:30653,MIM:609987 stimulated by retinoic acid 8 GO:0005634,GO:0005737,GO:0006260,GO:0006351,GO:0045944,GO:0046983,GO:0048133,GO:0048477,GO:0051321,GO:0071300 nucleus|cytoplasm|DNA replication|transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|male germ-line stem cell asymmetric division|oogenesis|meiotic cell cycle|cellular response to retinoic acid STRADA 805.992462567843 801.694549315593 810.290375820094 1.01072207178138 0.0153863396875949 0.941508045496872 1 8.14904 8.35447 8.7161 8.56688 GeneID:92335,Genbank:NM_001003786.2,HGNC:HGNC:30172,MIM:608626 STE20-related kinase adaptor alpha GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006611,GO:0007050,GO:0007346,GO:0019900,GO:0030295,GO:0031098,GO:0032147,GO:0042981,GO:0043539 ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein export from nucleus|cell cycle arrest|regulation of mitotic cell cycle|kinase binding|protein kinase activator activity|stress-activated protein kinase signaling cascade|activation of protein kinase activity|regulation of apoptotic process|protein serine/threonine kinase activator activity hsa04150,hsa04152 mTOR signaling pathway|AMPK signaling pathway STRADB 750.11950324739 728.674927424801 771.564079069979 1.0588591016803 0.0825106282056919 0.616312011401525 1 11.7794 12.8966 13.8256 11.9795 GeneID:55437,Genbank:NM_001206864.1,HGNC:HGNC:13205,MIM:607333 STE20-related kinase adaptor beta GO:0000902,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006611,GO:0007050,GO:0007346,GO:0016235,GO:0031098,GO:0032147,GO:0042981,GO:2001240 cell morphogenesis|ATP binding|nucleus|cytoplasm|cytosol|protein export from nucleus|cell cycle arrest|regulation of mitotic cell cycle|aggresome|stress-activated protein kinase signaling cascade|activation of protein kinase activity|regulation of apoptotic process|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa04150,hsa04152 mTOR signaling pathway|AMPK signaling pathway STRAP 2221.32218760002 2308.75907882353 2133.88529637651 0.924256374755162 -0.11363500592473 0.424440040967777 1 51.4346 50.4194 50.1219 44.1706 GeneID:11171,Genbank:NM_007178.3,HGNC:HGNC:30796,MIM:605986 serine/threonine kinase receptor associated protein GO:0000122,GO:0000387,GO:0003723,GO:0005102,GO:0005654,GO:0005737,GO:0005829,GO:0010633,GO:0010719,GO:0030277,GO:0030512,GO:0032797,GO:0034719,GO:0050680,GO:0060394 negative regulation of transcription from RNA polymerase II promoter|spliceosomal snRNP assembly|RNA binding|receptor binding|nucleoplasm|cytoplasm|cytosol|negative regulation of epithelial cell migration|negative regulation of epithelial to mesenchymal transition|maintenance of gastrointestinal epithelium|negative regulation of transforming growth factor beta receptor signaling pathway|SMN complex|SMN-Sm protein complex|negative regulation of epithelial cell proliferation|negative regulation of pathway-restricted SMAD protein phosphorylation hsa03013 RNA transport STRBP 485.135546047903 465.712566330964 504.558525764842 1.08341187728714 0.115581812064607 0.548156695230841 1 1.56488 1.37507 1.99346 1.3757 GeneID:55342,Genbank:XM_017014898.1,HGNC:HGNC:16462,MIM:611138 spermatid perinuclear RNA binding protein GO:0003677,GO:0003723,GO:0003725,GO:0003727,GO:0005634,GO:0005737,GO:0007275,GO:0007286,GO:0007638,GO:0015630 DNA binding|RNA binding|double-stranded RNA binding|single-stranded RNA binding|nucleus|cytoplasm|multicellular organism development|spermatid development|mechanosensory behavior|microtubule cytoskeleton STRC 1.4593380350783 0.980142803914724 1.93853326624189 1.97780696700452 0.983901626635446 0.869495943289778 1 0 0.00820824 0.0173791 0.00812513 GeneID:161497,Genbank:NM_153700.2,HGNC:HGNC:16035,MIM:606440 stereocilin GO:0007160,GO:0007605,GO:0009986,GO:0032426,GO:0050910,GO:0060088,GO:0060091 cell-matrix adhesion|sensory perception of sound|cell surface|stereocilium tip|detection of mechanical stimulus involved in sensory perception of sound|auditory receptor cell stereocilium organization|kinocilium STRIP1 1038.87668378081 1043.10256037756 1034.65080718407 0.991897485909315 -0.0117370712637752 0.94009522789905 1 11.2791 11.2212 11.2993 11.3946 GeneID:85369,Genbank:NM_001270768.1,HGNC:HGNC:25916 striatin interacting protein 1 GO:0005634,GO:0005829,GO:0017048,GO:0019901,GO:0022604,GO:0030866,GO:0070062 nucleus|cytosol|Rho GTPase binding|protein kinase binding|regulation of cell morphogenesis|cortical actin cytoskeleton organization|extracellular exosome STRIP2 316.187464755991 343.514333456766 288.860596055216 0.840898233120077 -0.249996881156937 0.207477766904606 1 1.31798 1.41786 1.30616 1.0629 GeneID:57464,Genbank:NM_020704.2,HGNC:HGNC:22209 striatin interacting protein 2 GO:0005737,GO:0005829,GO:0007010,GO:0008360,GO:0016477 cytoplasm|cytosol|cytoskeleton organization|regulation of cell shape|cell migration STRN 378.251265016826 401.716143429252 354.786386604401 0.883176821264302 -0.179225785413776 0.350873287605539 1 1.12723 1.08983 1.06211 0.803128 GeneID:6801,Genbank:XM_011533073.2,HGNC:HGNC:11424,MIM:614765 striatin STRN3 248.277485349799 287.185548196994 209.369422502604 0.729038852466867 -0.455932393136714 0.0344935119990782 0.730000079237491 2.63351 2.25008 2.05593 1.66154 GeneID:29966,Genbank:NM_014574.3,HGNC:HGNC:15720,MIM:614766 striatin 3 GO:0000122,GO:0003700,GO:0005516,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005886,GO:0017048,GO:0030425,GO:0032355,GO:0032403,GO:0033147,GO:0043025,GO:0043234,GO:0045892,GO:0045944,GO:0051721,GO:0070016 negative regulation of transcription from RNA polymerase II promoter|DNA binding transcription factor activity|calmodulin binding|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|plasma membrane|Rho GTPase binding|dendrite|response to estradiol|protein complex binding|negative regulation of intracellular estrogen receptor signaling pathway|neuronal cell body|protein complex|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein phosphatase 2A binding|armadillo repeat domain binding STRN4 4101.84412679337 4111.52978581136 4092.15846777539 0.995288537589387 -0.0068132663123055 0.944386318548961 1 30.8403 31.4303 32.619 31.5514 GeneID:29888,Genbank:XM_017026719.1,HGNC:HGNC:15721,MIM:614767 striatin 4 GO:0005516,GO:0005737,GO:0016020,GO:0032403,GO:0043197,GO:0043234,GO:0051721,GO:0070016 calmodulin binding|cytoplasm|membrane|protein complex binding|dendritic spine|protein complex|protein phosphatase 2A binding|armadillo repeat domain binding STS 199.612773088078 211.168679965519 188.056866210638 0.89055283312537 -0.16722689139097 0.474764099092588 1 0.995753 0.985086 1.06261 0.767866 GeneID:412,Genbank:NM_001320750.1,HGNC:HGNC:11425,MIM:300747 steroid sulfatase hsa00140 Steroid hormone biosynthesis STT3A 7114.84978934278 6877.41148544979 7352.28809323576 1.06904874149099 0.0963276318275963 0.467599770628285 1 62.3553 66.4892 71.3455 67.6355 GeneID:3703,Genbank:NM_001278503.1,HGNC:HGNC:6172,MIM:601134 STT3A, catalytic subunit of the oligosaccharyltransferase complex GO:0004579,GO:0008250,GO:0016021,GO:0018279,GO:0043686,GO:0046872 dolichyl-diphosphooligosaccharide-protein glycotransferase activity|oligosaccharyltransferase complex|integral component of membrane|protein N-linked glycosylation via asparagine|co-translational protein modification|metal ion binding hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum STT3B 3465.19195795417 3577.89208935618 3352.49182655216 0.93700193936129 -0.0938760609793991 0.606727043640337 1 21.8013 20.4947 23.0107 17.4605 GeneID:201595,Genbank:NM_178862.2,HGNC:HGNC:30611,MIM:608605 STT3B, catalytic subunit of the oligosaccharyltransferase complex GO:0004579,GO:0005783,GO:0006516,GO:0006986,GO:0008250,GO:0016020,GO:0016021,GO:0018279,GO:0030433,GO:0043686,GO:0043687,GO:0046872 dolichyl-diphosphooligosaccharide-protein glycotransferase activity|endoplasmic reticulum|glycoprotein catabolic process|response to unfolded protein|oligosaccharyltransferase complex|membrane|integral component of membrane|protein N-linked glycosylation via asparagine|ubiquitin-dependent ERAD pathway|co-translational protein modification|post-translational protein modification|metal ion binding hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum STUB1 3039.86851046721 2943.32678176743 3136.41023916699 1.06560041467214 0.0916665489382183 0.518399494529964 1 66.7981 68.1943 73.6367 75.8811 GeneID:10273,Genbank:NM_001293197.1,HGNC:HGNC:11427,MIM:607207 STIP1 homology and U-box containing protein 1 GO:0000151,GO:0000209,GO:0001664,GO:0004842,GO:0005654,GO:0005737,GO:0005783,GO:0005829,GO:0006281,GO:0006511,GO:0006515,GO:0016567,GO:0019899,GO:0019900,GO:0030018,GO:0030512,GO:0030544,GO:0030579,GO:0030674,GO:0030911,GO:0030968,GO:0031371,GO:0031398,GO:0031625,GO:0031647,GO:0031943,GO:0032091,GO:0032436,GO:0034450,GO:0038128,GO:0042405,GO:0042787,GO:0042803,GO:0043161,GO:0046332,GO:0051443,GO:0051604,GO:0051787,GO:0051865,GO:0051879,GO:0061630,GO:0070062,GO:0070534,GO:0071218,GO:0090035,GO:1904264 ubiquitin ligase complex|protein polyubiquitination|G-protein coupled receptor binding|ubiquitin-protein transferase activity|nucleoplasm|cytoplasm|endoplasmic reticulum|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|protein quality control for misfolded or incompletely synthesized proteins|protein ubiquitination|enzyme binding|kinase binding|Z disc|negative regulation of transforming growth factor beta receptor signaling pathway|Hsp70 protein binding|ubiquitin-dependent SMAD protein catabolic process|protein binding, bridging|TPR domain binding|endoplasmic reticulum unfolded protein response|ubiquitin conjugating enzyme complex|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|regulation of protein stability|regulation of glucocorticoid metabolic process|negative regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin-ubiquitin ligase activity|ERBB2 signaling pathway|nuclear inclusion body|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|SMAD binding|positive regulation of ubiquitin-protein transferase activity|protein maturation|misfolded protein binding|protein autoubiquitination|Hsp90 protein binding|ubiquitin protein ligase activity|extracellular exosome|protein K63-linked ubiquitination|cellular response to misfolded protein|positive regulation of chaperone-mediated protein complex assembly|ubiquitin protein ligase activity involved in ERAD pathway hsa04120,hsa04141 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum STX10 1219.01982803378 1177.57321261176 1260.46644345581 1.07039327148093 0.0981409523031392 0.530326931972308 1 14.5049 16.5604 17.4518 18.469 GeneID:8677,Genbank:NM_001271611.1,HGNC:HGNC:11428,MIM:603765 syntaxin 10 GO:0005484,GO:0005802,GO:0005829,GO:0006886,GO:0006906,GO:0016021,GO:0019905,GO:0031201,GO:0031982,GO:0032588,GO:0032880,GO:0042147,GO:0048193,GO:0048278,GO:0048471 SNAP receptor activity|trans-Golgi network|cytosol|intracellular protein transport|vesicle fusion|integral component of membrane|syntaxin binding|SNARE complex|vesicle|trans-Golgi network membrane|regulation of protein localization|retrograde transport, endosome to Golgi|Golgi vesicle transport|vesicle docking|perinuclear region of cytoplasm hsa04130 SNARE interactions in vesicular transport STX11 88.2604143738256 82.5132749716139 94.0075537760373 1.1393021766301 0.188150443189442 0.581860757883391 1 0.430589 0.652592 0.549117 0.696489 GeneID:8676,Genbank:XM_011536213.2,HGNC:HGNC:11429,MIM:605014 syntaxin 11 hsa04130 SNARE interactions in vesicular transport STX12 868.244459423629 659.133831622395 1077.35508722486 1.63450127354722 0.708850501204011 6.19082538669291e-06 0.00330507531310912 9.47701 9.97854 16.8778 15.2053 GeneID:23673,Genbank:NM_177424.2,HGNC:HGNC:11430,MIM:606892 syntaxin 12 GO:0000045,GO:0000139,GO:0000149,GO:0000407,GO:0005484,GO:0006886,GO:0006906,GO:0012505,GO:0016021,GO:0031201,GO:0031901,GO:0031982,GO:0033344,GO:0045121,GO:0045335,GO:0048278,GO:0050821,GO:0055038,GO:0070062 autophagosome assembly|Golgi membrane|SNARE binding|phagophore assembly site|SNAP receptor activity|intracellular protein transport|vesicle fusion|endomembrane system|integral component of membrane|SNARE complex|early endosome membrane|vesicle|cholesterol efflux|membrane raft|phagocytic vesicle|vesicle docking|protein stabilization|recycling endosome membrane|extracellular exosome hsa04145 Phagosome STX16 2248.05836543809 2312.67965003919 2183.43708083699 0.944115662884822 -0.0829644810114734 0.561731071272368 1 20.5549 19.5379 21.394 16.9698 GeneID:8675,Genbank:NM_001001433.2,HGNC:HGNC:11431,MIM:603666 syntaxin 16 GO:0000139,GO:0005484,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0005925,GO:0006886,GO:0006906,GO:0016020,GO:0016021,GO:0019905,GO:0031201,GO:0031985,GO:0032588,GO:0042147,GO:0043231,GO:0048278,GO:0048471,GO:0090161 Golgi membrane|SNAP receptor activity|cytoplasm|Golgi apparatus|trans-Golgi network|cytosol|focal adhesion|intracellular protein transport|vesicle fusion|membrane|integral component of membrane|syntaxin binding|SNARE complex|Golgi cisterna|trans-Golgi network membrane|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|vesicle docking|perinuclear region of cytoplasm|Golgi ribbon formation hsa04130 SNARE interactions in vesicular transport STX17 267.589349954391 251.641675573278 283.537024335504 1.12674907162959 0.172166261363729 0.424719824303687 1 1.33464 1.19297 1.61146 1.25807 GeneID:55014,Genbank:NM_017919.2,HGNC:HGNC:11432,MIM:604204 syntaxin 17 GO:0000149,GO:0000421,GO:0005484,GO:0005739,GO:0005776,GO:0005789,GO:0005793,GO:0005829,GO:0005886,GO:0006886,GO:0006887,GO:0006888,GO:0006906,GO:0007030,GO:0012507,GO:0016021,GO:0016240,GO:0019901,GO:0019903,GO:0030134,GO:0030868,GO:0031201,GO:0033116,GO:0034497,GO:0044233,GO:0048278,GO:0097111,GO:0097352 SNARE binding|autophagosome membrane|SNAP receptor activity|mitochondrion|autophagosome|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|cytosol|plasma membrane|intracellular protein transport|exocytosis|ER to Golgi vesicle-mediated transport|vesicle fusion|Golgi organization|ER to Golgi transport vesicle membrane|integral component of membrane|autophagosome membrane docking|protein kinase binding|protein phosphatase binding|COPII-coated ER to Golgi transport vesicle|smooth endoplasmic reticulum membrane|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|protein localization to phagophore assembly site|ER-mitochondrion membrane contact site|vesicle docking|endoplasmic reticulum-Golgi intermediate compartment organization|autophagosome maturation hsa04130,hsa04140 SNARE interactions in vesicular transport|Autophagy - animal STX18 650.923449577794 657.817504895686 644.029394259903 0.979039611239946 -0.0305608634717166 0.854459035859721 1 3.85199 3.93452 3.32558 3.8588 GeneID:53407,Genbank:NM_001346282.1,HGNC:HGNC:15942,MIM:606046 syntaxin 18 GO:0000139,GO:0005484,GO:0005783,GO:0005789,GO:0006886,GO:0006890,GO:0016021,GO:0019904,GO:0031201,GO:0090158,GO:1902117,GO:1902953,GO:1903358 Golgi membrane|SNAP receptor activity|endoplasmic reticulum|endoplasmic reticulum membrane|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER|integral component of membrane|protein domain specific binding|SNARE complex|endoplasmic reticulum membrane organization|positive regulation of organelle assembly|positive regulation of ER to Golgi vesicle-mediated transport|regulation of Golgi organization hsa04130,hsa04145 SNARE interactions in vesicular transport|Phagosome STX1A 615.581432715824 661.248004709387 569.91486072226 0.861877626341924 -0.214445052026144 0.196234094543994 1 6.90759 6.37408 5.79858 6.12381 GeneID:6804,Genbank:NM_001165903.1,HGNC:HGNC:11433,MIM:186590 syntaxin 1A GO:0000149,GO:0001956,GO:0005484,GO:0005576,GO:0005829,GO:0005886,GO:0006886,GO:0007269,GO:0008021,GO:0008076,GO:0009629,GO:0010701,GO:0010807,GO:0014047,GO:0014069,GO:0016021,GO:0016081,GO:0017022,GO:0019221,GO:0019855,GO:0019869,GO:0019900,GO:0019904,GO:0030054,GO:0030141,GO:0030424,GO:0030672,GO:0030674,GO:0031201,GO:0031629,GO:0031965,GO:0032028,GO:0032940,GO:0033605,GO:0035493,GO:0042641,GO:0043005,GO:0043008,GO:0044325,GO:0045956,GO:0046982,GO:0047485,GO:0048278,GO:0048306,GO:0048787,GO:0050796,GO:0070032,GO:0070033,GO:0070044,GO:0072657,GO:2000463 SNARE binding|positive regulation of neurotransmitter secretion|SNAP receptor activity|extracellular region|cytosol|plasma membrane|intracellular protein transport|neurotransmitter secretion|synaptic vesicle|voltage-gated potassium channel complex|response to gravity|positive regulation of norepinephrine secretion|regulation of synaptic vesicle priming|glutamate secretion|postsynaptic density|integral component of membrane|synaptic vesicle docking|myosin binding|cytokine-mediated signaling pathway|calcium channel inhibitor activity|chloride channel inhibitor activity|kinase binding|protein domain specific binding|cell junction|secretory granule|axon|synaptic vesicle membrane|protein binding, bridging|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|nuclear membrane|myosin head/neck binding|secretion by cell|positive regulation of catecholamine secretion|SNARE complex assembly|actomyosin|neuron projection|ATP-dependent protein binding|ion channel binding|positive regulation of calcium ion-dependent exocytosis|protein heterodimerization activity|protein N-terminus binding|vesicle docking|calcium-dependent protein binding|presynaptic active zone membrane|regulation of insulin secretion|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex|synaptobrevin 2-SNAP-25-syntaxin-1a complex|protein localization to membrane|positive regulation of excitatory postsynaptic potential hsa04130,hsa04721,hsa04911,hsa05031 SNARE interactions in vesicular transport|Synaptic vesicle cycle|Insulin secretion|Amphetamine addiction STX1B 5.0069669997804 7.59120240278514 2.42273159677566 0.319149914364921 -1.64769383420105 0.240585823936392 1 0.042895 0.0598866 0.00799356 0.0149262 GeneID:112755,Genbank:NM_052874.4,HGNC:HGNC:18539,MIM:601485 syntaxin 1B GO:0000149,GO:0001956,GO:0005102,GO:0005484,GO:0005634,GO:0005652,GO:0005654,GO:0005737,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005886,GO:0006886,GO:0006904,GO:0008021,GO:0010468,GO:0010807,GO:0010977,GO:0016020,GO:0016021,GO:0016081,GO:0019901,GO:0019904,GO:0030424,GO:0031201,GO:0031629,GO:0048278,GO:0048787,GO:0048791,GO:0060025,GO:0061669,GO:0098967,GO:1903422,GO:1904050,GO:1905302,GO:2000463 SNARE binding|positive regulation of neurotransmitter secretion|receptor binding|SNAP receptor activity|nucleus|nuclear lamina|nucleoplasm|cytoplasm|centrosome|microtubule organizing center|spindle|cytosol|plasma membrane|intracellular protein transport|vesicle docking involved in exocytosis|synaptic vesicle|regulation of gene expression|regulation of synaptic vesicle priming|negative regulation of neuron projection development|membrane|integral component of membrane|synaptic vesicle docking|protein kinase binding|protein domain specific binding|axon|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|vesicle docking|presynaptic active zone membrane|calcium ion-regulated exocytosis of neurotransmitter|regulation of synaptic activity|spontaneous neurotransmitter secretion|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|negative regulation of synaptic vesicle recycling|positive regulation of spontaneous neurotransmitter secretion|negative regulation of macropinocytosis|positive regulation of excitatory postsynaptic potential hsa04130,hsa04721 SNARE interactions in vesicular transport|Synaptic vesicle cycle STX2 556.628773590919 499.719598164762 613.537949017076 1.22776443283457 0.296033782057937 0.0834243807021632 0.963076417285947 1.67338 1.82308 2.24523 2.37888 GeneID:2054,Genbank:NM_001351049.1,HGNC:HGNC:3403,MIM:132350 syntaxin 2 GO:0000149,GO:0005484,GO:0005615,GO:0005886,GO:0006886,GO:0007165,GO:0007340,GO:0007398,GO:0008021,GO:0009887,GO:0016021,GO:0016323,GO:0030027,GO:0030154,GO:0031201,GO:0031629,GO:0033194,GO:0043231,GO:0046983,GO:0048278,GO:0048306,GO:0051259,GO:0070062,GO:1903575 SNARE binding|SNAP receptor activity|extracellular space|plasma membrane|intracellular protein transport|signal transduction|acrosome reaction|ectoderm development|synaptic vesicle|animal organ morphogenesis|integral component of membrane|basolateral plasma membrane|lamellipodium|cell differentiation|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|response to hydroperoxide|intracellular membrane-bounded organelle|protein dimerization activity|vesicle docking|calcium-dependent protein binding|protein oligomerization|extracellular exosome|cornified envelope assembly hsa04130,hsa04721 SNARE interactions in vesicular transport|Synaptic vesicle cycle STX3 1519.23785233775 1645.20581292927 1393.26989174623 0.846866623492858 -0.239793323414028 0.0992777923691778 1 8.46948 8.22205 6.95863 7.2401 GeneID:6809,Genbank:NM_004177.4,HGNC:HGNC:11438,MIM:600876 syntaxin 3 GO:0000149,GO:0005484,GO:0005773,GO:0005886,GO:0005911,GO:0006886,GO:0008021,GO:0008284,GO:0016021,GO:0016081,GO:0016324,GO:0019221,GO:0030027,GO:0030425,GO:0030426,GO:0031175,GO:0031201,GO:0031629,GO:0042470,GO:0042581,GO:0042582,GO:0042589,GO:0042734,GO:0043005,GO:0045785,GO:0048278,GO:0050544,GO:0050921,GO:0060291,GO:0070062,GO:0097470,GO:0098794,GO:0098967,GO:1903078,GO:1990796,GO:2000010 SNARE binding|SNAP receptor activity|vacuole|plasma membrane|cell-cell junction|intracellular protein transport|synaptic vesicle|positive regulation of cell proliferation|integral component of membrane|synaptic vesicle docking|apical plasma membrane|cytokine-mediated signaling pathway|lamellipodium|dendrite|growth cone|neuron projection development|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|melanosome|specific granule|azurophil granule|zymogen granule membrane|presynaptic membrane|neuron projection|positive regulation of cell adhesion|vesicle docking|arachidonic acid binding|positive regulation of chemotaxis|long-term synaptic potentiation|extracellular exosome|ribbon synapse|postsynapse|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|positive regulation of protein localization to plasma membrane|photoreceptor cell terminal bouton|positive regulation of protein localization to cell surface hsa04130,hsa04721 SNARE interactions in vesicular transport|Synaptic vesicle cycle STX4 576.383882599158 552.809988709573 599.957776488742 1.08528751061323 0.118077287083284 0.49878496567134 1 6.54978 7.48721 8.28943 8.31349 GeneID:6810,Genbank:NM_001272096.1,HGNC:HGNC:11439,MIM:186591 syntaxin 4 GO:0000149,GO:0000322,GO:0005484,GO:0005615,GO:0005622,GO:0005768,GO:0005773,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0006892,GO:0008021,GO:0008284,GO:0009986,GO:0016020,GO:0016021,GO:0016230,GO:0016323,GO:0017157,GO:0019221,GO:0030027,GO:0030335,GO:0030670,GO:0031201,GO:0031629,GO:0033194,GO:0035493,GO:0035749,GO:0035774,GO:0036477,GO:0042581,GO:0043085,GO:0043197,GO:0043219,GO:0043311,GO:0045202,GO:0045785,GO:0048278,GO:0048284,GO:0048471,GO:0050921,GO:0051024,GO:0060291,GO:0070062,GO:0071346,GO:1902041,GO:1903078,GO:1990668,GO:2000010 SNARE binding|storage vacuole|SNAP receptor activity|extracellular space|intracellular|endosome|vacuole|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|post-Golgi vesicle-mediated transport|synaptic vesicle|positive regulation of cell proliferation|cell surface|membrane|integral component of membrane|sphingomyelin phosphodiesterase activator activity|basolateral plasma membrane|regulation of exocytosis|cytokine-mediated signaling pathway|lamellipodium|positive regulation of cell migration|phagocytic vesicle membrane|SNARE complex|synaptic vesicle fusion to presynaptic active zone membrane|response to hydroperoxide|SNARE complex assembly|myelin sheath adaxonal region|positive regulation of insulin secretion involved in cellular response to glucose stimulus|somatodendritic compartment|specific granule|positive regulation of catalytic activity|dendritic spine|lateral loop|positive regulation of eosinophil degranulation|synapse|positive regulation of cell adhesion|vesicle docking|organelle fusion|perinuclear region of cytoplasm|positive regulation of chemotaxis|positive regulation of immunoglobulin secretion|long-term synaptic potentiation|extracellular exosome|cellular response to interferon-gamma|regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of protein localization to plasma membrane|vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane|positive regulation of protein localization to cell surface hsa04130,hsa04962 SNARE interactions in vesicular transport|Vasopressin-regulated water reabsorption STX5 693.124771396052 677.256664839709 708.992877952395 1.04685994949964 0.0660684492629675 0.691424066857831 1 12.0152 11.2055 11.8793 12.3899 GeneID:6811,Genbank:NM_001330294.1,HGNC:HGNC:11440,MIM:603189 syntaxin 5 GO:0000139,GO:0000149,GO:0005484,GO:0005789,GO:0005794,GO:0005829,GO:0006886,GO:0006888,GO:0006906,GO:0012507,GO:0016021,GO:0031201,GO:0031982,GO:0033116,GO:0034498,GO:0042147,GO:0045296,GO:0045732,GO:0047485,GO:0048208,GO:0048278,GO:0048280,GO:0090166,GO:1903358 Golgi membrane|SNARE binding|SNAP receptor activity|endoplasmic reticulum membrane|Golgi apparatus|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|vesicle fusion|ER to Golgi transport vesicle membrane|integral component of membrane|SNARE complex|vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|early endosome to Golgi transport|retrograde transport, endosome to Golgi|cadherin binding|positive regulation of protein catabolic process|protein N-terminus binding|COPII vesicle coating|vesicle docking|vesicle fusion with Golgi apparatus|Golgi disassembly|regulation of Golgi organization hsa04130 SNARE interactions in vesicular transport STX6 946.01105754046 1001.68763958546 890.334475495457 0.888834443304015 -0.170013371070924 0.267150397313253 1 7.70206 8.26484 7.86307 6.3455 GeneID:10228,Genbank:NM_001286210.1,HGNC:HGNC:11441,MIM:603944 syntaxin 6 GO:0000139,GO:0005484,GO:0005654,GO:0005769,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006886,GO:0006906,GO:0007032,GO:0016021,GO:0019905,GO:0030136,GO:0030285,GO:0031201,GO:0032456,GO:0032588,GO:0032880,GO:0042147,GO:0043195,GO:0045335,GO:0048193,GO:0048278,GO:0048471,GO:0090161,GO:1903827 Golgi membrane|SNAP receptor activity|nucleoplasm|early endosome|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|intracellular protein transport|vesicle fusion|endosome organization|integral component of membrane|syntaxin binding|clathrin-coated vesicle|integral component of synaptic vesicle membrane|SNARE complex|endocytic recycling|trans-Golgi network membrane|regulation of protein localization|retrograde transport, endosome to Golgi|terminal bouton|phagocytic vesicle|Golgi vesicle transport|vesicle docking|perinuclear region of cytoplasm|Golgi ribbon formation|regulation of cellular protein localization hsa04130 SNARE interactions in vesicular transport STX7 1029.83962485556 1072.89882934588 986.780420365232 0.919732963980256 -0.120713046177642 0.446036608927784 1 8.27154 7.3779 8.36313 6.31044 GeneID:8417,Genbank:NM_001326579.1,HGNC:HGNC:11442,MIM:603217 syntaxin 7 GO:0000149,GO:0001772,GO:0001916,GO:0005484,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005886,GO:0006886,GO:0006906,GO:0016021,GO:0019869,GO:0019905,GO:0030139,GO:0031201,GO:0031901,GO:0031982,GO:0042582,GO:0048278,GO:0048471,GO:0051640,GO:0055037,GO:0070062,GO:0070820,GO:0070925,GO:1902685,GO:1903076 SNARE binding|immunological synapse|positive regulation of T cell mediated cytotoxicity|SNAP receptor activity|lysosome|lysosomal membrane|endosome|early endosome|late endosome|plasma membrane|intracellular protein transport|vesicle fusion|integral component of membrane|chloride channel inhibitor activity|syntaxin binding|endocytic vesicle|SNARE complex|early endosome membrane|vesicle|azurophil granule|vesicle docking|perinuclear region of cytoplasm|organelle localization|recycling endosome|extracellular exosome|tertiary granule|organelle assembly|positive regulation of receptor localization to synapse|regulation of protein localization to plasma membrane hsa04130,hsa04145 SNARE interactions in vesicular transport|Phagosome STX8 566.290182146081 571.461110948421 561.11925334374 0.981902779722809 -0.0263479075726782 0.912446903066586 1 10.7859 13.2991 10.5805 13.3832 GeneID:9482,Genbank:NM_004853.2,HGNC:HGNC:11443,MIM:604203 syntaxin 8 GO:0005484,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005783,GO:0005802,GO:0005829,GO:0005887,GO:0006810,GO:0006886,GO:0006906,GO:0008333,GO:0019869,GO:0019905,GO:0031201,GO:0031625,GO:0031902,GO:0031982,GO:0045022,GO:0045335,GO:0048278,GO:0048471,GO:0055037,GO:0071346,GO:1903076 SNAP receptor activity|lysosomal membrane|endosome|early endosome|late endosome|endoplasmic reticulum|trans-Golgi network|cytosol|integral component of plasma membrane|transport|intracellular protein transport|vesicle fusion|endosome to lysosome transport|chloride channel inhibitor activity|syntaxin binding|SNARE complex|ubiquitin protein ligase binding|late endosome membrane|vesicle|early endosome to late endosome transport|phagocytic vesicle|vesicle docking|perinuclear region of cytoplasm|recycling endosome|cellular response to interferon-gamma|regulation of protein localization to plasma membrane hsa04130 SNARE interactions in vesicular transport STXBP1 781.417714885239 791.806877382184 771.028552388295 0.973758342359207 -0.0383643118376232 0.797345079744435 1 6.72224 7.38819 7.11111 6.9324 GeneID:6812,Genbank:NM_003165.3,HGNC:HGNC:11444,MIM:602926 syntaxin binding protein 1 GO:0000149,GO:0002576,GO:0003006,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005856,GO:0005886,GO:0006887,GO:0006904,GO:0007269,GO:0007274,GO:0007412,GO:0010807,GO:0015031,GO:0016188,GO:0017075,GO:0019901,GO:0019904,GO:0019905,GO:0030424,GO:0031091,GO:0031333,GO:0031338,GO:0032229,GO:0032355,GO:0035544,GO:0042802,GO:0043195,GO:0043209,GO:0043234,GO:0043274,GO:0043306,GO:0043524,GO:0045335,GO:0045921,GO:0045956,GO:0047485,GO:0048471,GO:0048787,GO:0050821,GO:0060292,GO:0070062,GO:0070527,GO:0071346,GO:0072659,GO:0098793,GO:0098794,GO:0099525,GO:0106022,GO:1903296 SNARE binding|platelet degranulation|developmental process involved in reproduction|RNA binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|cytoskeleton|plasma membrane|exocytosis|vesicle docking involved in exocytosis|neurotransmitter secretion|neuromuscular synaptic transmission|axon target recognition|regulation of synaptic vesicle priming|protein transport|synaptic vesicle maturation|syntaxin-1 binding|protein kinase binding|protein domain specific binding|syntaxin binding|axon|platelet alpha granule|negative regulation of protein complex assembly|regulation of vesicle fusion|negative regulation of synaptic transmission, GABAergic|response to estradiol|negative regulation of SNARE complex assembly|identical protein binding|terminal bouton|myelin sheath|protein complex|phospholipase binding|positive regulation of mast cell degranulation|negative regulation of neuron apoptotic process|phagocytic vesicle|positive regulation of exocytosis|positive regulation of calcium ion-dependent exocytosis|protein N-terminus binding|perinuclear region of cytoplasm|presynaptic active zone membrane|protein stabilization|long term synaptic depression|extracellular exosome|platelet aggregation|cellular response to interferon-gamma|protein localization to plasma membrane|presynapse|postsynapse|presynaptic dense core vesicle exocytosis|positive regulation of vesicle docking|positive regulation of glutamate secretion, neurotransmission hsa04721 Synaptic vesicle cycle STXBP2 1.50649433770985 1.07619535328461 1.93679332213509 1.7996670550787 0.847730027434814 0.867084781262262 1 0.0182795 0 0 0.0473306 GeneID:6813,Genbank:NM_001272034.1,HGNC:HGNC:11445,MIM:601717 syntaxin binding protein 2 GO:0001909,GO:0002576,GO:0005576,GO:0005829,GO:0005886,GO:0006904,GO:0015031,GO:0016324,GO:0017075,GO:0030348,GO:0042581,GO:0042582,GO:0042589,GO:0043304,GO:0043312,GO:0044194,GO:0045335,GO:0070062,GO:0070820,GO:0071346 leukocyte mediated cytotoxicity|platelet degranulation|extracellular region|cytosol|plasma membrane|vesicle docking involved in exocytosis|protein transport|apical plasma membrane|syntaxin-1 binding|syntaxin-3 binding|specific granule|azurophil granule|zymogen granule membrane|regulation of mast cell degranulation|neutrophil degranulation|cytolytic granule|phagocytic vesicle|extracellular exosome|tertiary granule|cellular response to interferon-gamma STXBP3 294.295677411767 305.068250040883 283.52310478265 0.929375983061672 -0.105665731688735 0.61956836519491 1 4.34999 4.18786 4.34057 3.63755 GeneID:6814,Genbank:NM_007269.3,HGNC:HGNC:11446,MIM:608339 syntaxin binding protein 3 GO:0005829,GO:0005886,GO:0006904,GO:0007420,GO:0015758,GO:0016323,GO:0016324,GO:0017075,GO:0019905,GO:0022615,GO:0030073,GO:0031091,GO:0032868,GO:0042581,GO:0043312,GO:0045335,GO:0045955,GO:0051291,GO:0070062,GO:0070527,GO:0070820,GO:0071346 cytosol|plasma membrane|vesicle docking involved in exocytosis|brain development|glucose transport|basolateral plasma membrane|apical plasma membrane|syntaxin-1 binding|syntaxin binding|protein to membrane docking|insulin secretion|platelet alpha granule|response to insulin|specific granule|neutrophil degranulation|phagocytic vesicle|negative regulation of calcium ion-dependent exocytosis|protein heterooligomerization|extracellular exosome|platelet aggregation|tertiary granule|cellular response to interferon-gamma STXBP4 74.9518429633541 73.8262599053283 76.0774260213799 1.03049275581532 0.0433343630178341 0.895724914800161 1 0.27976 0.281961 0.261128 0.292061 GeneID:252983,Genbank:XM_017024410.1,HGNC:HGNC:19694,MIM:610415 syntaxin binding protein 4 GO:0006605,GO:0006974,GO:0008286,GO:0010838,GO:0015758,GO:0019905,GO:0045335,GO:0050821,GO:0061178,GO:0070062,GO:0071346,GO:1902808 protein targeting|cellular response to DNA damage stimulus|insulin receptor signaling pathway|positive regulation of keratinocyte proliferation|glucose transport|syntaxin binding|phagocytic vesicle|protein stabilization|regulation of insulin secretion involved in cellular response to glucose stimulus|extracellular exosome|cellular response to interferon-gamma|positive regulation of cell cycle G1/S phase transition STXBP5 343.290910294788 346.820371756629 339.761448832946 0.979646746562407 -0.0296664771464859 0.867449887755385 1 1.06101 1.27873 1.27984 1.01248 GeneID:134957,Genbank:XM_006715339.3,HGNC:HGNC:19665,MIM:604586 syntaxin binding protein 5 GO:0005096,GO:0005737,GO:0005829,GO:0005886,GO:0005892,GO:0006887,GO:0008021,GO:0015031,GO:0017075,GO:0017137,GO:0017157,GO:0019905,GO:0030054,GO:0030659,GO:0045921,GO:0050708 GTPase activator activity|cytoplasm|cytosol|plasma membrane|acetylcholine-gated channel complex|exocytosis|synaptic vesicle|protein transport|syntaxin-1 binding|Rab GTPase binding|regulation of exocytosis|syntaxin binding|cell junction|cytoplasmic vesicle membrane|positive regulation of exocytosis|regulation of protein secretion STXBP6 69.662264767336 66.1488136082812 73.1757159263909 1.10622869761084 0.145649673819716 0.692434763328181 1 0.255923 0.277285 0.208901 0.329808 GeneID:29091,Genbank:NM_001351942.1,HGNC:HGNC:19666,MIM:607958 syntaxin binding protein 6 GO:0000145,GO:0005546,GO:0005886,GO:0005913,GO:0006893,GO:0016021,GO:0017049,GO:0035542,GO:0045920,GO:0051601,GO:0098641 exocyst|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane|cell-cell adherens junction|Golgi to plasma membrane transport|integral component of membrane|GTP-Rho binding|regulation of SNARE complex assembly|negative regulation of exocytosis|exocyst localization|cadherin binding involved in cell-cell adhesion STYK1 20.2201304027831 16.200765229062 24.2394955765041 1.49619448425941 0.581297717498251 0.47038656977539 1 0.194203 0.0970739 0.306275 0.152716 GeneID:55359,Genbank:XM_005253417.2,HGNC:HGNC:18889,MIM:611433 serine/threonine/tyrosine kinase 1 GO:0004715,GO:0005102,GO:0005524,GO:0005886,GO:0006935,GO:0007155,GO:0007173,GO:0016021,GO:0016477,GO:0030154,GO:0031234,GO:0038083,GO:0042127,GO:0043304,GO:0045087 non-membrane spanning protein tyrosine kinase activity|receptor binding|ATP binding|plasma membrane|chemotaxis|cell adhesion|epidermal growth factor receptor signaling pathway|integral component of membrane|cell migration|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|regulation of mast cell degranulation|innate immune response STYX 206.610704154084 242.148022492456 171.073385815713 0.706482687964312 -0.501273886478247 0.0282315324433948 0.668561867500627 2.43498 2.06844 1.58748 1.40951 GeneID:6815,Genbank:NM_145251.3,HGNC:HGNC:11447,MIM:615814 serine/threonine/tyrosine interacting protein GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007283,GO:0008138,GO:0045204,GO:0070372 nucleus|nucleoplasm|cytoplasm|cytosol|spermatogenesis|protein tyrosine/serine/threonine phosphatase activity|MAPK export from nucleus|regulation of ERK1 and ERK2 cascade STYXL1 893.805922808046 807.315657455441 980.296188160652 1.21426628990502 0.280084840866516 0.193208194573896 1 5.36416 5.70102 6.55345 7.94254 GeneID:51657,Genbank:XM_017012298.2,HGNC:HGNC:18165,MIM:616695 serine/threonine/tyrosine interacting like 1 GO:0005622,GO:0008138,GO:0035556 intracellular|protein tyrosine/serine/threonine phosphatase activity|intracellular signal transduction SUB1 1757.82529514385 1930.47808479226 1585.17250549543 0.82112950050195 -0.284318327209857 0.0493318166574415 0.813062736622003 21.6927 19.3376 16.3671 17.0277 GeneID:10923,Genbank:XM_017008986.1,HGNC:HGNC:19985,MIM:600503 SUB1 homolog, transcriptional regulator GO:0001205,GO:0003697,GO:0003713,GO:0003723,GO:0005634,GO:0005667,GO:0005730,GO:0006357,GO:0042802,GO:0060261,GO:0060395,GO:0070062 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|single-stranded DNA binding|transcription coactivator activity|RNA binding|nucleus|transcription factor complex|nucleolus|regulation of transcription from RNA polymerase II promoter|identical protein binding|positive regulation of transcription initiation from RNA polymerase II promoter|SMAD protein signal transduction|extracellular exosome SUCLA2 443.012378361949 480.846944861849 405.177811862049 0.842633640894733 -0.247022580383854 0.173178989799802 1 8.69137 8.5262 7.96701 6.74557 GeneID:8803,Genbank:NM_003850.2,HGNC:HGNC:11448,MIM:603921 succinate-CoA ligase ADP-forming beta subunit GO:0004775,GO:0005524,GO:0005739,GO:0005759,GO:0006099,GO:0006104,GO:0006105,GO:0006781,GO:0043209,GO:0046872,GO:0070062 succinate-CoA ligase (ADP-forming) activity|ATP binding|mitochondrion|mitochondrial matrix|tricarboxylic acid cycle|succinyl-CoA metabolic process|succinate metabolic process|succinyl-CoA pathway|myelin sheath|metal ion binding|extracellular exosome hsa00020,hsa00640 Citrate cycle (TCA cycle)|Propanoate metabolism SUCLG1 1377.74603187271 1446.15464784374 1309.33741590169 0.905392392061219 -0.143384911100003 0.38608714978205 1 38.641 39.1452 32.2803 37.4386 GeneID:8802,Genbank:NM_003849.3,HGNC:HGNC:11449,MIM:611224 succinate-CoA ligase alpha subunit GO:0000166,GO:0003723,GO:0004775,GO:0004776,GO:0005739,GO:0005743,GO:0005759,GO:0005829,GO:0005886,GO:0006099,GO:0048037,GO:0070062 nucleotide binding|RNA binding|succinate-CoA ligase (ADP-forming) activity|succinate-CoA ligase (GDP-forming) activity|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|cytosol|plasma membrane|tricarboxylic acid cycle|cofactor binding|extracellular exosome hsa00020,hsa00640 Citrate cycle (TCA cycle)|Propanoate metabolism SUCLG2 1614.0273103817 1655.88152256785 1572.17309819556 0.949447817835129 -0.0748393836323794 0.610241786164874 1 17.1095 17.3125 17.1723 15.3009 GeneID:8801,Genbank:NM_001177599.1,HGNC:HGNC:11450,MIM:603922 succinate-CoA ligase GDP-forming beta subunit GO:0004776,GO:0005524,GO:0005525,GO:0005739,GO:0005759,GO:0005886,GO:0006099,GO:0006104,GO:0006105,GO:0019003,GO:0045244,GO:0046872,GO:0046982 succinate-CoA ligase (GDP-forming) activity|ATP binding|GTP binding|mitochondrion|mitochondrial matrix|plasma membrane|tricarboxylic acid cycle|succinyl-CoA metabolic process|succinate metabolic process|GDP binding|succinate-CoA ligase complex (GDP-forming)|metal ion binding|protein heterodimerization activity hsa00020,hsa00640 Citrate cycle (TCA cycle)|Propanoate metabolism SUCO 606.773876657015 605.206360096869 608.341393217161 1.00518010603819 0.00745402360134701 0.969740162925874 1 3.87149 3.1934 4.67534 2.71242 GeneID:51430,Genbank:NM_016227.3,HGNC:HGNC:1240 SUN domain containing ossification factor GO:0001503,GO:0005791,GO:0007275,GO:0016020,GO:0016021,GO:0030867,GO:0032967,GO:0045669,GO:0046850 ossification|rough endoplasmic reticulum|multicellular organism development|membrane|integral component of membrane|rough endoplasmic reticulum membrane|positive regulation of collagen biosynthetic process|positive regulation of osteoblast differentiation|regulation of bone remodeling SUDS3 816.525834832635 874.597484345945 758.454185319325 0.867203712444387 -0.205557162095898 0.196813177942669 1 5.42125 5.28518 4.74749 4.4016 GeneID:64426,Genbank:XM_011538671.2,HGNC:HGNC:29545,MIM:608250 SDS3 homolog, SIN3A corepressor complex component GO:0000122,GO:0004407,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006915,GO:0016575,GO:0016579,GO:0016580,GO:0016604,GO:0019899,GO:0021762,GO:0042826,GO:0043065,GO:0045892,GO:0070822 negative regulation of transcription from RNA polymerase II promoter|histone deacetylase activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|apoptotic process|histone deacetylation|protein deubiquitination|Sin3 complex|nuclear body|enzyme binding|substantia nigra development|histone deacetylase binding|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|Sin3-type complex SUFU 578.782402334781 569.231268001844 588.333536667718 1.03355801014398 0.0476193646688723 0.778110395877409 1 3.60664 3.435 3.78003 3.73563 GeneID:51684,Genbank:XM_011539863.3,HGNC:HGNC:16466,MIM:607035 SUFU negative regulator of hedgehog signaling GO:0000122,GO:0001501,GO:0001843,GO:0001947,GO:0003281,GO:0003714,GO:0004871,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0007165,GO:0007275,GO:0008013,GO:0008134,GO:0019901,GO:0021775,GO:0021776,GO:0035904,GO:0042992,GO:0042994,GO:0043433,GO:0043588,GO:0045668,GO:0045879,GO:0060976,GO:0097542,GO:0097546,GO:1901621,GO:2000059 negative regulation of transcription from RNA polymerase II promoter|skeletal system development|neural tube closure|heart looping|ventricular septum development|transcription corepressor activity|signal transducer activity|nucleus|cytoplasm|cytosol|regulation of transcription, DNA-templated|proteolysis|signal transduction|multicellular organism development|beta-catenin binding|transcription factor binding|protein kinase binding|smoothened signaling pathway involved in ventral spinal cord interneuron specification|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|aorta development|negative regulation of transcription factor import into nucleus|cytoplasmic sequestering of transcription factor|negative regulation of DNA binding transcription factor activity|skin development|negative regulation of osteoblast differentiation|negative regulation of smoothened signaling pathway|coronary vasculature development|ciliary tip|ciliary base|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process hsa04340,hsa05200,hsa05217 Hedgehog signaling pathway|Pathways in cancer|Basal cell carcinoma SUGCT 23.4217779043678 22.6197197291927 24.223836079543 1.07091672087697 0.0988462942345347 0.898685679634106 1 0.0748139 0.0727085 0.0622683 0.134733 GeneID:79783,Genbank:XM_011515525.3,HGNC:HGNC:16001,MIM:609187 succinyl-CoA:glutarate-CoA transferase GO:0005739,GO:0008152,GO:0033608,GO:0047369 mitochondrion|metabolic process|formyl-CoA transferase activity|succinate-hydroxymethylglutarate CoA-transferase activity SUGP1 969.660319872217 916.773050879601 1022.54758886483 1.11537701493706 0.157531446148577 0.317423944957857 1 8.62012 9.86855 10.1944 10.7475 GeneID:57794,Genbank:NM_172231.3,HGNC:HGNC:18643,MIM:607992 SURP and G-patch domain containing 1 GO:0000398,GO:0003723,GO:0005654,GO:0005681 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|spliceosomal complex SUGP2 5382.46963745011 5331.4841853606 5433.45508953962 1.01912617587032 0.0273326796031782 0.837950255829662 1 26.3611 26.3146 29.8197 24.9809 GeneID:10147,Genbank:NM_001321697.1,HGNC:HGNC:18641,MIM:607993 SURP and G-patch domain containing 2 GO:0003723,GO:0005654,GO:0006397,GO:0008380,GO:0016604 RNA binding|nucleoplasm|mRNA processing|RNA splicing|nuclear body SUGT1 531.023062885786 567.261173738906 494.784952032666 0.872234827515978 -0.197211497862194 0.258694480736648 1 1.40287 1.28031 1.10415 1.218 GeneID:10910,Genbank:NM_001320831.1,HGNC:HGNC:16987,MIM:604098 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone GO:0000151,GO:0000278,GO:0000776,GO:0005634,GO:0005829,GO:0031647,GO:0043234,GO:0043947 ubiquitin ligase complex|mitotic cell cycle|kinetochore|nucleus|cytosol|regulation of protein stability|protein complex|positive regulation by host of symbiont catalytic activity hsa04621 NOD-like receptor signaling pathway SULF1 6.41077411111848 7.0050784514579 5.81646977077905 0.830321860216788 -0.268257413694032 0.855961456979485 1 0.0172155 0.0162757 0.0384909 0.0153514 GeneID:23213,Genbank:NM_015170.2,HGNC:HGNC:20391,MIM:610012 sulfatase 1 SULF2 1452.27076881151 1516.55345893793 1387.98807868508 0.915225289622906 -0.127801177485368 0.364840030473162 1 5.11407 6.08492 5.56811 5.02103 GeneID:55959,Genbank:XM_005260458.3,HGNC:HGNC:20392,MIM:610013 sulfatase 2 GO:0001822,GO:0002063,GO:0003094,GO:0004065,GO:0005509,GO:0005615,GO:0005783,GO:0005795,GO:0005886,GO:0008449,GO:0009611,GO:0009986,GO:0010575,GO:0014846,GO:0030177,GO:0030201,GO:0032836,GO:0035413,GO:0035860,GO:0040037,GO:0048706,GO:0051216,GO:0060348,GO:0060384,GO:0090263,GO:0097421,GO:2000345 kidney development|chondrocyte development|glomerular filtration|arylsulfatase activity|calcium ion binding|extracellular space|endoplasmic reticulum|Golgi stack|plasma membrane|N-acetylglucosamine-6-sulfatase activity|response to wounding|cell surface|positive regulation of vascular endothelial growth factor production|esophagus smooth muscle contraction|positive regulation of Wnt signaling pathway|heparan sulfate proteoglycan metabolic process|glomerular basement membrane development|positive regulation of catenin import into nucleus|glial cell-derived neurotrophic factor receptor signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|embryonic skeletal system development|cartilage development|bone development|innervation|positive regulation of canonical Wnt signaling pathway|liver regeneration|regulation of hepatocyte proliferation SULT1A1 18.9872770377179 21.9855695031805 15.9889845722553 0.727249051699219 -0.459478584771442 0.494787332003644 1 0.120174 0.26914 0.158519 0.118386 GeneID:6817,Genbank:NM_177536.3,HGNC:HGNC:11453,MIM:171150 sulfotransferase family 1A member 1 GO:0004062,GO:0005829,GO:0006068,GO:0006584,GO:0006805,GO:0008146,GO:0008210,GO:0009308,GO:0009812,GO:0047894,GO:0050294,GO:0050427,GO:0051923 aryl sulfotransferase activity|cytosol|ethanol catabolic process|catecholamine metabolic process|xenobiotic metabolic process|sulfotransferase activity|estrogen metabolic process|amine metabolic process|flavonoid metabolic process|flavonol 3-sulfotransferase activity|steroid sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation hsa05204 Chemical carcinogenesis SULT1A2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:6799,Genbank:XM_024450406.1,HGNC:HGNC:11454,MIM:601292 sulfotransferase family 1A member 2 GO:0004062,GO:0005829,GO:0006068,GO:0006584,GO:0006805,GO:0008146,GO:0008202,GO:0009309,GO:0018958,GO:0047894,GO:0050427,GO:0051923 aryl sulfotransferase activity|cytosol|ethanol catabolic process|catecholamine metabolic process|xenobiotic metabolic process|sulfotransferase activity|steroid metabolic process|amine biosynthetic process|phenol-containing compound metabolic process|flavonol 3-sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation hsa05204 Chemical carcinogenesis SULT1A3 1.04924568023034 1.61429302992691 0.484198330533773 0.299944509179783 -1.73723247328634 0.787670862996782 1 0.0280775 0 0 0.0243136 GeneID:6818,Genbank:NM_177552.3,HGNC:HGNC:11455,MIM:600641 sulfotransferase family 1A member 3 GO:0004062,GO:0005829,GO:0006068,GO:0006805,GO:0007212,GO:0008146,GO:0008202,GO:0009812,GO:0036498,GO:0042420,GO:0043199,GO:0047685,GO:0050427,GO:0051923,GO:0070371,GO:0097720,GO:0098989,GO:1901215,GO:1903351 aryl sulfotransferase activity|cytosol|ethanol catabolic process|xenobiotic metabolic process|dopamine receptor signaling pathway|sulfotransferase activity|steroid metabolic process|flavonoid metabolic process|IRE1-mediated unfolded protein response|dopamine catabolic process|sulfate binding|amine sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|ERK1 and ERK2 cascade|calcineurin-mediated signaling|NMDA selective glutamate receptor signaling pathway|negative regulation of neuron death|cellular response to dopamine hsa05204 Chemical carcinogenesis SULT1A4 7.60560740023913 3.084507235799 12.1267075646793 3.93148942039619 1.97507597211291 0.505422782214797 1 0.0281509 0.074916 0.602311 0 GeneID:445329,Genbank:NM_001017390.2,HGNC:HGNC:30004,MIM:615819 sulfotransferase family 1A member 4 GO:0004062,GO:0005829,GO:0006068,GO:0006805,GO:0007212,GO:0008146,GO:0008202,GO:0009812,GO:0036498,GO:0042420,GO:0043199,GO:0047685,GO:0050427,GO:0051923,GO:0070371,GO:0097720,GO:0098989,GO:1901215,GO:1903351 aryl sulfotransferase activity|cytosol|ethanol catabolic process|xenobiotic metabolic process|dopamine receptor signaling pathway|sulfotransferase activity|steroid metabolic process|flavonoid metabolic process|IRE1-mediated unfolded protein response|dopamine catabolic process|sulfate binding|amine sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation|ERK1 and ERK2 cascade|calcineurin-mediated signaling|NMDA selective glutamate receptor signaling pathway|negative regulation of neuron death|cellular response to dopamine hsa05204 Chemical carcinogenesis SULT2A1 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0347756 0 0 GeneID:6822,Genbank:NM_003167.3,HGNC:HGNC:11458,MIM:125263 sulfotransferase family 2A member 1 GO:0004062,GO:0004304,GO:0005829,GO:0006068,GO:0007586,GO:0008146,GO:0008202,GO:0016042,GO:0019216,GO:0030573,GO:0047704,GO:0050294,GO:0050427,GO:0051923 aryl sulfotransferase activity|estrone sulfotransferase activity|cytosol|ethanol catabolic process|digestion|sulfotransferase activity|steroid metabolic process|lipid catabolic process|regulation of lipid metabolic process|bile acid catabolic process|bile-salt sulfotransferase activity|steroid sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|sulfation hsa00980,hsa04976,hsa05204 Metabolism of xenobiotics by cytochrome P450|Bile secretion|Chemical carcinogenesis SULT2B1 12.0453296193358 5.67894306964064 18.4117161690309 3.2421026136816 1.69692975338068 0.046759342577782 0.79332376136203 0.134108 0.0875952 0.310218 0.522054 GeneID:6820,Genbank:NM_177973.1,HGNC:HGNC:11459,MIM:604125 sulfotransferase family 2B member 1 GO:0000103,GO:0003676,GO:0004027,GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0008202,GO:0008203,GO:0008285,GO:0015485,GO:0043231,GO:0045606,GO:0050294,GO:0050427,GO:0070062,GO:1990239 sulfate assimilation|nucleic acid binding|alcohol sulfotransferase activity|nucleus|cytoplasm|endoplasmic reticulum|cytosol|steroid metabolic process|cholesterol metabolic process|negative regulation of cell proliferation|cholesterol binding|intracellular membrane-bounded organelle|positive regulation of epidermal cell differentiation|steroid sulfotransferase activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|extracellular exosome|steroid hormone binding hsa00140 Steroid hormone biosynthesis SUMF1 1115.19395362857 1028.11226067073 1202.27564658642 1.16940113699458 0.225769899145213 0.132594200329075 1 5.64114 5.63505 6.20679 7.07154 GeneID:285362,Genbank:XM_017006254.2,HGNC:HGNC:20376,MIM:607939 sulfatase modifying factor 1 GO:0005783,GO:0005788,GO:0006687,GO:0016491,GO:0042803,GO:0043687,GO:0046872 endoplasmic reticulum|endoplasmic reticulum lumen|glycosphingolipid metabolic process|oxidoreductase activity|protein homodimerization activity|post-translational protein modification|metal ion binding hsa04142 Lysosome SUMF2 4537.02412838033 3954.17087351007 5119.87738325059 1.29480428313047 0.372734043011337 0.00547683197449304 0.289494854466933 59.379 61.6929 77.9747 82.5383 GeneID:25870,Genbank:XM_017011940.1,HGNC:HGNC:20415,MIM:607940 sulfatase modifying factor 2 GO:0005788,GO:0046872 endoplasmic reticulum lumen|metal ion binding SUMO1 2003.32890758756 2132.09527674717 1874.56253842796 0.879211430592298 -0.185717952058336 0.197319823052332 1 56.2985 52.3135 49.5699 45.8309 GeneID:7341,Genbank:NM_001005782.1,HGNC:HGNC:12502,MIM:601912 small ubiquitin-like modifier 1 hsa03013,hsa05418 RNA transport|Fluid shear stress and atherosclerosis SUMO2 7100.71892006714 7073.84859739126 7127.58924274301 1.00759708730147 0.0109188567383827 0.936311488814653 1 254.414 259.862 255.826 267.222 GeneID:6613,Genbank:NM_001005849.1,HGNC:HGNC:11125,MIM:603042 small ubiquitin-like modifier 2 GO:0001222,GO:0005634,GO:0016605,GO:0016925,GO:0031386,GO:0031625,GO:0032436 transcription corepressor binding|nucleus|PML body|protein sumoylation|protein tag|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process hsa03013,hsa05418 RNA transport|Fluid shear stress and atherosclerosis SUMO3 4552.27307751354 4422.21914399209 4682.32701103499 1.05881840283657 0.0824551749840384 0.54676586443559 1 88.9891 93.3134 98.1691 99.8596 GeneID:6612,Genbank:NM_006936.2,HGNC:HGNC:11124,MIM:602231 small ubiquitin-like modifier 3 hsa03013,hsa05418 RNA transport|Fluid shear stress and atherosclerosis SUMO4 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:387082,Genbank:NM_001002255.1,HGNC:HGNC:21181,MIM:608829 small ubiquitin-like modifier 4 hsa03013,hsa05418 RNA transport|Fluid shear stress and atherosclerosis SUN1 4245.89984129956 4246.87166864243 4244.92801395669 0.999542332606824 -0.000660425617677007 0.990687153117272 1 34.7703 36.8135 37.8888 35.6473 GeneID:23353,Genbank:NM_001171946.1,HGNC:HGNC:18587,MIM:607723 Sad1 and UNC84 domain containing 1 GO:0001503,GO:0002080,GO:0005521,GO:0005635,GO:0005639,GO:0006998,GO:0007129,GO:0007283,GO:0009612,GO:0021817,GO:0031965,GO:0034993,GO:0043231,GO:0043495,GO:0051642,GO:0070197,GO:0090286,GO:0090292 ossification|acrosomal membrane|lamin binding|nuclear envelope|integral component of nuclear inner membrane|nuclear envelope organization|synapsis|spermatogenesis|response to mechanical stimulus|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration|nuclear membrane|LINC complex|intracellular membrane-bounded organelle|protein membrane anchor|centrosome localization|meiotic attachment of telomere to nuclear envelope|cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane SUN2 4244.99335339238 4230.09763911971 4259.88906766504 1.00704272834504 0.0101248975092631 0.977445002317203 1 22.4577 23.5207 21.3057 25.8805 GeneID:25777,Genbank:NM_015374.2,HGNC:HGNC:14210,MIM:613569 Sad1 and UNC84 domain containing 2 GO:0000784,GO:0000794,GO:0005521,GO:0005635,GO:0005639,GO:0006998,GO:0007052,GO:0007097,GO:0008017,GO:0010008,GO:0021817,GO:0030335,GO:0031022,GO:0031965,GO:0034993,GO:0042802,GO:0043495,GO:0051321,GO:0051642,GO:0090286,GO:0090292 nuclear chromosome, telomeric region|condensed nuclear chromosome|lamin binding|nuclear envelope|integral component of nuclear inner membrane|nuclear envelope organization|mitotic spindle organization|nuclear migration|microtubule binding|endosome membrane|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration|positive regulation of cell migration|nuclear migration along microfilament|nuclear membrane|LINC complex|identical protein binding|protein membrane anchor|meiotic cell cycle|centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane SUN3 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:256979,Genbank:XM_017011930.1,HGNC:HGNC:22429 Sad1 and UNC84 domain containing 3 GO:0005635,GO:0005637,GO:0006998,GO:0016021,GO:0034993,GO:0043495,GO:0090286 nuclear envelope|nuclear inner membrane|nuclear envelope organization|integral component of membrane|LINC complex|protein membrane anchor|cytoskeletal anchoring at nuclear membrane SUOX 417.406457847727 410.768768383656 424.044147311798 1.03231837459401 0.0458879771683333 0.824828558468433 1 3.78545 4.29222 4.13998 4.24841 GeneID:6821,Genbank:XM_017019907.2,HGNC:HGNC:11460,MIM:606887 sulfite oxidase GO:0005758,GO:0005759,GO:0008482,GO:0020037,GO:0030151,GO:0042128,GO:0043546,GO:0070221 mitochondrial intermembrane space|mitochondrial matrix|sulfite oxidase activity|heme binding|molybdenum ion binding|nitrate assimilation|molybdopterin cofactor binding|sulfide oxidation, using sulfide:quinone oxidoreductase hsa00920 Sulfur metabolism SUPT16H 2558.59530519882 2598.87321277545 2518.3173976222 0.969003560944311 -0.0454261275470487 0.810266671759327 1 14.9549 13.3637 15.5941 12.6469 GeneID:11198,Genbank:NM_007192.3,HGNC:HGNC:11465,MIM:605012 SPT16 homolog, facilitates chromatin remodeling subunit GO:0003723,GO:0005634,GO:0005654,GO:0005694,GO:0006260,GO:0006281,GO:0006337,GO:0006366,GO:0006368,GO:0031491,GO:0032786,GO:0032968,GO:0034724,GO:0035101,GO:0042393,GO:1901796 RNA binding|nucleus|nucleoplasm|chromosome|DNA replication|DNA repair|nucleosome disassembly|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|nucleosome binding|positive regulation of DNA-templated transcription, elongation|positive regulation of transcription elongation from RNA polymerase II promoter|DNA replication-independent nucleosome organization|FACT complex|histone binding|regulation of signal transduction by p53 class mediator SUPT20H 537.07369156311 539.086972453912 535.060410672309 0.992530775204465 -0.0108162585798604 0.981212645181112 1 4.63376 3.59559 4.44052 3.48362 GeneID:55578,Genbank:NM_001014286.2,HGNC:HGNC:20596,MIM:613417 SPT20 homolog, SAGA complex component GO:0000124,GO:0001650,GO:0003712,GO:0006914,GO:0007369,GO:0070461 SAGA complex|fibrillar center|transcription cofactor activity|autophagy|gastrulation|SAGA-type complex hsa04140 Autophagy - animal SUPT3H 116.255589335036 118.623654236441 113.887524433631 0.960074322163686 -0.0587820014841932 0.871472819578241 1 0.478399 0.317335 0.370706 0.330967 GeneID:8464,Genbank:NM_001261823.1,HGNC:HGNC:11466,MIM:602947 SPT3 homolog, SAGA and STAGA complex component GO:0000124,GO:0003677,GO:0003713,GO:0005634,GO:0005654,GO:0006355,GO:0006357,GO:0006366,GO:0016578,GO:0030914,GO:0033276,GO:0043966,GO:0045893,GO:0046982 SAGA complex|DNA binding|transcription coactivator activity|nucleus|nucleoplasm|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|histone deubiquitination|STAGA complex|transcription factor TFTC complex|histone H3 acetylation|positive regulation of transcription, DNA-templated|protein heterodimerization activity hsa05202 Transcriptional misregulation in cancer SUPT4H1 1616.41264643874 1685.04567531187 1547.7796175656 0.918538672418561 -0.122587631763073 0.394097910746117 1 48.5371 49.9791 43.2641 48.971 GeneID:6827,Genbank:NM_003168.2,HGNC:HGNC:11467,MIM:603555 SPT4 homolog, DSIF elongation factor subunit GO:0000122,GO:0000993,GO:0003700,GO:0003727,GO:0005634,GO:0006325,GO:0006368,GO:0006397,GO:0008270,GO:0032044,GO:0032785,GO:0032786,GO:0034244,GO:0045944,GO:0046982 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II core binding|DNA binding transcription factor activity|single-stranded RNA binding|nucleus|chromatin organization|transcription elongation from RNA polymerase II promoter|mRNA processing|zinc ion binding|DSIF complex|negative regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|negative regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity SUPT5H 4183.92198913673 4092.63853219908 4275.20544607438 1.04460860944326 0.0629624992592517 0.653782799581237 1 25.6562 26.9002 27.0333 29.1118 GeneID:6829,Genbank:NM_001111020.2,HGNC:HGNC:11469,MIM:602102 SPT5 homolog, DSIF elongation factor subunit GO:0000122,GO:0003677,GO:0003682,GO:0003723,GO:0003729,GO:0005634,GO:0005654,GO:0006338,GO:0006354,GO:0006366,GO:0006368,GO:0006370,GO:0007049,GO:0010033,GO:0016239,GO:0019899,GO:0032044,GO:0032785,GO:0032786,GO:0039692,GO:0045944,GO:0046982,GO:0050434,GO:1900364 negative regulation of transcription from RNA polymerase II promoter|DNA binding|chromatin binding|RNA binding|mRNA binding|nucleus|nucleoplasm|chromatin remodeling|DNA-templated transcription, elongation|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|cell cycle|response to organic substance|positive regulation of macroautophagy|enzyme binding|DSIF complex|negative regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|single stranded viral RNA replication via double stranded DNA intermediate|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|positive regulation of viral transcription|negative regulation of mRNA polyadenylation SUPT6H 5232.82081045711 5177.24022326129 5288.40139765294 1.02147112546414 0.030648423123066 0.821602870257827 1 20.4715 20.5744 22.5122 20.1774 GeneID:6830,Genbank:NM_001320755.1,HGNC:HGNC:11470,MIM:601333 SPT6 homolog, histone chaperone GO:0000991,GO:0003677,GO:0003700,GO:0003723,GO:0005634,GO:0005654,GO:0006338,GO:0006342,GO:0006355,GO:0006366,GO:0006368,GO:0006397,GO:0008023,GO:0008380,GO:0010793,GO:0016032,GO:0031491,GO:0032968,GO:0034728,GO:0035327,GO:0042393,GO:0042789,GO:0045191,GO:0050684,GO:0051028,GO:0051147,GO:0061086,GO:0070827 transcription factor activity, core RNA polymerase II binding|DNA binding|DNA binding transcription factor activity|RNA binding|nucleus|nucleoplasm|chromatin remodeling|chromatin silencing|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|mRNA processing|transcription elongation factor complex|RNA splicing|regulation of mRNA export from nucleus|viral process|nucleosome binding|positive regulation of transcription elongation from RNA polymerase II promoter|nucleosome organization|transcriptionally active chromatin|histone binding|mRNA transcription from RNA polymerase II promoter|regulation of isotype switching|regulation of mRNA processing|mRNA transport|regulation of muscle cell differentiation|negative regulation of histone H3-K27 methylation|chromatin maintenance SUPT7L 933.493252066378 963.11709465574 903.869409477015 0.938483404035204 -0.0915968619546122 0.546149621459202 1 6.62783 7.39131 7.14649 6.33856 GeneID:9913,Genbank:NM_001282732.1,HGNC:HGNC:30632,MIM:612762 SPT7 like, STAGA complex gamma subunit GO:0003713,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0030914,GO:0043966,GO:0051457 transcription coactivator activity|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|STAGA complex|histone H3 acetylation|maintenance of protein location in nucleus SUPV3L1 920.086676261142 963.481687543004 876.691664979279 0.909920423308667 -0.136187714320992 0.380452426069562 1 12.4027 12.7837 11.8738 11.5633 GeneID:6832,Genbank:NM_001323585.1,HGNC:HGNC:11471,MIM:605122 Suv3 like RNA helicase GO:0000958,GO:0000962,GO:0000965,GO:0003677,GO:0003678,GO:0003723,GO:0003725,GO:0004004,GO:0004386,GO:0005524,GO:0005634,GO:0005739,GO:0005759,GO:0006310,GO:0006401,GO:0030307,GO:0032508,GO:0034458,GO:0035945,GO:0035946,GO:0042645,GO:0042803,GO:0043066,GO:0045025,GO:0070584,GO:0070827,GO:2000827 mitochondrial mRNA catabolic process|positive regulation of mitochondrial RNA catabolic process|mitochondrial RNA 3'-end processing|DNA binding|DNA helicase activity|RNA binding|double-stranded RNA binding|ATP-dependent RNA helicase activity|helicase activity|ATP binding|nucleus|mitochondrion|mitochondrial matrix|DNA recombination|RNA catabolic process|positive regulation of cell growth|DNA duplex unwinding|3'-5' RNA helicase activity|mitochondrial ncRNA surveillance|mitochondrial mRNA surveillance|mitochondrial nucleoid|protein homodimerization activity|negative regulation of apoptotic process|mitochondrial degradosome|mitochondrion morphogenesis|chromatin maintenance|mitochondrial RNA surveillance SURF1 583.032457368772 576.803870095268 589.261044642276 1.02159689834423 0.0308260500140961 0.874992134474923 1 14.2982 16.4127 14.0061 17.4229 GeneID:6834,Genbank:NM_001280787.1,HGNC:HGNC:11474,MIM:185620 SURF1, cytochrome c oxidase assembly factor SURF2 420.754832536828 429.621804376353 411.887860697304 0.958721965462643 -0.0608156083258774 0.766639980769957 1 18.1256 19.1643 15.6729 19.1479 GeneID:6835,Genbank:NM_017503.4,HGNC:HGNC:11475,MIM:185630 surfeit 2 GO:0005634,GO:0005730,GO:0005886,GO:0016607 nucleus|nucleolus|plasma membrane|nuclear speck SURF4 8322.08757513501 7511.9389367724 9132.23621349762 1.21569627899843 0.2817828410235 0.0324175300241 0.713066454646352 56.7154 59.2658 73.0666 71.4446 GeneID:6836,Genbank:NM_001280788.1,HGNC:HGNC:11476,MIM:185660 surfeit 4 GO:0000139,GO:0005789,GO:0005793,GO:0005886,GO:0006890,GO:0007030,GO:0010638,GO:0016021,GO:0030133,GO:0033116,GO:0035577,GO:0043312 Golgi membrane|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|plasma membrane|retrograde vesicle-mediated transport, Golgi to ER|Golgi organization|positive regulation of organelle organization|integral component of membrane|transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|azurophil granule membrane|neutrophil degranulation SURF6 821.241853567447 863.691451989044 778.79225514585 0.901701936903886 -0.149277474283326 0.346857335070022 1 13.1016 12.6521 11.8791 11.4937 GeneID:6838,Genbank:NM_006753.5,HGNC:HGNC:11478,MIM:185642 surfeit 6 GO:0001652,GO:0003677,GO:0003723,GO:0005654,GO:0005730,GO:0022625,GO:0042273,GO:0042274 granular component|DNA binding|RNA binding|nucleoplasm|nucleolus|cytosolic large ribosomal subunit|ribosomal large subunit biogenesis|ribosomal small subunit biogenesis SUSD1 43.7162550367669 43.8172515271982 43.6152585463356 0.995390103810205 -0.00666605110621883 1 1 0.393679 0.303652 0.342685 0.357831 GeneID:64420,Genbank:NM_022486.4,HGNC:HGNC:25413 sushi domain containing 1 GO:0005509,GO:0016021 calcium ion binding|integral component of membrane SUSD2 19.1373243934766 17.9209194634667 20.3537293234864 1.13575251342316 0.183648498085932 0.817388937182029 1 0.217474 0.234618 0.239451 0.224107 GeneID:56241,Genbank:NM_019601.3,HGNC:HGNC:30667,MIM:615825 sushi domain containing 2 GO:0005044,GO:0005886,GO:0006955,GO:0016021,GO:0030247,GO:0051782,GO:0070062,GO:1902807 scavenger receptor activity|plasma membrane|immune response|integral component of membrane|polysaccharide binding|negative regulation of cell division|extracellular exosome|negative regulation of cell cycle G1/S phase transition SUSD4 33.8309162333359 38.58035358483 29.0814788818419 0.753789848449624 -0.407765729030759 0.41895803660466 1 0.313416 0.265752 0.216657 0.174558 GeneID:55061,Genbank:NM_017982.3,HGNC:HGNC:25470,MIM:615827 sushi domain containing 4 GO:0005576,GO:0006958,GO:0016021,GO:0030449,GO:0045087,GO:0045957,GO:0045959 extracellular region|complement activation, classical pathway|integral component of membrane|regulation of complement activation|innate immune response|negative regulation of complement activation, alternative pathway|negative regulation of complement activation, classical pathway SUSD5 1.24038203510049 1.02816907859967 1.45259499160132 1.41279777989405 0.498554981013539 1 1 0 0.00727245 0 0.0209642 GeneID:26032,Genbank:XM_005265034.3,HGNC:HGNC:29061 sushi domain containing 5 GO:0005540,GO:0007155,GO:0007219,GO:0016021 hyaluronic acid binding|cell adhesion|Notch signaling pathway|integral component of membrane SUSD6 339.972446529302 325.199395140712 354.745497917891 1.09085534357896 0.125459801076733 0.511706596157884 1 2.5753 2.3595 2.82525 2.73763 GeneID:9766,Genbank:NM_014734.3,HGNC:HGNC:19956,MIM:616761 sushi domain containing 6 GO:0006974,GO:0008219,GO:0016021 cellular response to DNA damage stimulus|cell death|integral component of membrane SUV39H1 695.421179013369 673.077361941265 717.764996085473 1.06639301315279 0.0927392332487807 0.589510397836984 1 8.18479 9.19551 10.0545 8.81114 GeneID:6839,Genbank:NM_001282166.1,HGNC:HGNC:11479,MIM:300254 suppressor of variegation 3-9 homolog 1 GO:0000122,GO:0000183,GO:0000775,GO:0000792,GO:0000794,GO:0000976,GO:0003682,GO:0005634,GO:0005652,GO:0005654,GO:0005677,GO:0006325,GO:0006351,GO:0006364,GO:0006974,GO:0007049,GO:0008270,GO:0008757,GO:0016032,GO:0018024,GO:0030154,GO:0033553,GO:0036123,GO:0036124,GO:0042054,GO:0042754,GO:0045892,GO:0046974,GO:0047485,GO:0048511,GO:0071456 negative regulation of transcription from RNA polymerase II promoter|chromatin silencing at rDNA|chromosome, centromeric region|heterochromatin|condensed nuclear chromosome|transcription regulatory region sequence-specific DNA binding|chromatin binding|nucleus|nuclear lamina|nucleoplasm|chromatin silencing complex|chromatin organization|transcription, DNA-templated|rRNA processing|cellular response to DNA damage stimulus|cell cycle|zinc ion binding|S-adenosylmethionine-dependent methyltransferase activity|viral process|histone-lysine N-methyltransferase activity|cell differentiation|rDNA heterochromatin|histone H3-K9 dimethylation|histone H3-K9 trimethylation|histone methyltransferase activity|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|rhythmic process|cellular response to hypoxia hsa00310 Lysine degradation SUV39H2 206.868383859017 211.130462345942 202.606305372093 0.959626115155839 -0.0594556753831943 0.805077889426352 1 2.05074 2.22595 2.50269 1.75833 GeneID:79723,Genbank:NM_001193424.1,HGNC:HGNC:17287,MIM:606503 suppressor of variegation 3-9 homolog 2 GO:0000122,GO:0000775,GO:0000785,GO:0000976,GO:0005654,GO:0006333,GO:0006338,GO:0006351,GO:0007049,GO:0008270,GO:0018024,GO:0030154,GO:0036123,GO:0036124,GO:0042754,GO:0045892,GO:0046974,GO:0048511,GO:0071456,GO:1904047 negative regulation of transcription from RNA polymerase II promoter|chromosome, centromeric region|chromatin|transcription regulatory region sequence-specific DNA binding|nucleoplasm|chromatin assembly or disassembly|chromatin remodeling|transcription, DNA-templated|cell cycle|zinc ion binding|histone-lysine N-methyltransferase activity|cell differentiation|histone H3-K9 dimethylation|histone H3-K9 trimethylation|negative regulation of circadian rhythm|negative regulation of transcription, DNA-templated|histone methyltransferase activity (H3-K9 specific)|rhythmic process|cellular response to hypoxia|S-adenosyl-L-methionine binding hsa00310 Lysine degradation SUZ12 606.874862656301 675.227718646124 538.522006666477 0.797541320943176 -0.326368827451262 0.291937018888722 1 6.55413 5.77576 6.00902 3.74531 GeneID:23512,Genbank:NM_015355.3,HGNC:HGNC:17101,MIM:606245 SUZ12 polycomb repressive complex 2 subunit SV2A 3133.07620672639 3061.35450339744 3204.79791005535 1.04685618947388 0.0660632674998653 0.64324811372836 1 25.6108 27.5054 28.4796 28.2252 GeneID:9900,Genbank:NM_001328675.1,HGNC:HGNC:20566,MIM:185860 synaptic vesicle glycoprotein 2A GO:0006836,GO:0007268,GO:0016021,GO:0022857,GO:0030054,GO:0030672 neurotransmitter transport|chemical synaptic transmission|integral component of membrane|transmembrane transporter activity|cell junction|synaptic vesicle membrane hsa04512 ECM-receptor interaction SV2B 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00306075 0 0.00293216 0 GeneID:9899,Genbank:NM_001323031.2,HGNC:HGNC:16874,MIM:185861 synaptic vesicle glycoprotein 2B GO:0001669,GO:0005886,GO:0006836,GO:0007268,GO:0008021,GO:0016020,GO:0016021,GO:0022857,GO:0030054,GO:0030672 acrosomal vesicle|plasma membrane|neurotransmitter transport|chemical synaptic transmission|synaptic vesicle|membrane|integral component of membrane|transmembrane transporter activity|cell junction|synaptic vesicle membrane hsa04512 ECM-receptor interaction SV2C 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0 0.00297545 GeneID:22987,Genbank:XM_011543282.3,HGNC:HGNC:30670,MIM:610291 synaptic vesicle glycoprotein 2C GO:0005886,GO:0006836,GO:0007268,GO:0008021,GO:0016021,GO:0022857,GO:0030054,GO:0030672 plasma membrane|neurotransmitter transport|chemical synaptic transmission|synaptic vesicle|integral component of membrane|transmembrane transporter activity|cell junction|synaptic vesicle membrane hsa04512 ECM-receptor interaction SVBP 264.249099890166 255.677916648522 272.82028313181 1.06704672311161 0.0936233492884933 0.654209747537072 1 7.18669 6.6922 6.50971 7.9653 GeneID:374969,Genbank:NM_199342.3,HGNC:HGNC:29204,MIM:617853 small vasohibin binding protein GO:0005576,GO:0009306,GO:0010596,GO:0031397,GO:0045177 extracellular region|protein secretion|negative regulation of endothelial cell migration|negative regulation of protein ubiquitination|apical part of cell SVEP1 79.98263604799 53.3207132631278 106.644558832852 2.00005874464922 1.00004237468473 0.0570451032963322 0.86572937197041 0.129227 0.146233 0.378645 0.19545 GeneID:79987,Genbank:NM_153366.3,HGNC:HGNC:15985,MIM:611691 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 GO:0003682,GO:0005509,GO:0005615,GO:0005737,GO:0007155,GO:0016020 chromatin binding|calcium ion binding|extracellular space|cytoplasm|cell adhesion|membrane SVIL 2371.26229440893 2300.82188384284 2441.70270497502 1.06123065071725 0.0857382495439133 0.525825931152892 1 5.61061 5.23832 6.30303 5.23235 GeneID:6840,Genbank:XM_005252570.2,HGNC:HGNC:11480,MIM:604126 supervillin GO:0002102,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005925,GO:0007010,GO:0007519,GO:0015629,GO:0030496,GO:0032154,GO:0032467,GO:0036449,GO:0043034,GO:0051015,GO:0071437 podosome|nucleus|cytoplasm|cytosol|plasma membrane|focal adhesion|cytoskeleton organization|skeletal muscle tissue development|actin cytoskeleton|midbody|cleavage furrow|positive regulation of cytokinesis|microtubule minus-end|costamere|actin filament binding|invadopodium SVIP 237.192501703641 247.096762786715 227.288240620567 0.919834958812289 -0.120553065742347 0.598535730158614 1 1.2984 1.15237 1.13455 1.05487 GeneID:258010,Genbank:XM_024448423.1,HGNC:HGNC:25238 small VCP interacting protein GO:0000139,GO:0005789,GO:0005886,GO:0010508,GO:0030667,GO:0030868,GO:0031225,GO:0031333,GO:0043312,GO:0043621,GO:0051117,GO:0070062,GO:0070821,GO:1903061,GO:1903070,GO:1904153,GO:1904240 Golgi membrane|endoplasmic reticulum membrane|plasma membrane|positive regulation of autophagy|secretory granule membrane|smooth endoplasmic reticulum membrane|anchored component of membrane|negative regulation of protein complex assembly|neutrophil degranulation|protein self-association|ATPase binding|extracellular exosome|tertiary granule membrane|positive regulation of protein lipidation|negative regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of retrograde protein transport, ER to cytosol|negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly hsa04141 Protein processing in endoplasmic reticulum SWAP70 1027.30893008359 1063.97168290617 990.646177261021 0.931083216947219 -0.103017978325862 0.531012249283164 1 7.88915 7.07548 7.73407 6.31283 GeneID:23075,Genbank:NM_015055.3,HGNC:HGNC:17070,MIM:604762 switching B cell complex subunit SWAP70 GO:0003677,GO:0005509,GO:0005524,GO:0005634,GO:0005737,GO:0005856,GO:0005886,GO:0007204,GO:0030027,GO:0030835,GO:0032233,GO:0032880,GO:0033633,GO:0045190,GO:0045296,GO:0051017,GO:0060754,GO:1902309 DNA binding|calcium ion binding|ATP binding|nucleus|cytoplasm|cytoskeleton|plasma membrane|positive regulation of cytosolic calcium ion concentration|lamellipodium|negative regulation of actin filament depolymerization|positive regulation of actin filament bundle assembly|regulation of protein localization|negative regulation of cell-cell adhesion mediated by integrin|isotype switching|cadherin binding|actin filament bundle assembly|positive regulation of mast cell chemotaxis|negative regulation of peptidyl-serine dephosphorylation SWI5 496.402114733375 441.315874438428 551.488355028321 1.24964540586737 0.321518779870992 0.0682461243943452 0.917741333585082 4.28391 4.35336 4.92363 5.51002 GeneID:375757,Genbank:XM_024447540.1,HGNC:HGNC:31412,MIM:616528 SWI5 homologous recombination repair protein GO:0000724,GO:0000730,GO:0005634,GO:0032798,GO:0071479 double-strand break repair via homologous recombination|DNA recombinase assembly|nucleus|Swi5-Sfr1 complex|cellular response to ionizing radiation SWSAP1 55.3002622993349 62.6222612452098 47.97826335346 0.766153479600356 -0.384294666081208 0.326994684629468 1 1.52176 1.59527 1.27202 1.30316 GeneID:126074,Genbank:NM_175871.3,HGNC:HGNC:26638,MIM:614536 SWIM-type zinc finger 7 associated protein 1 GO:0000724,GO:0003697,GO:0005634,GO:0016887,GO:0050821,GO:0097196 double-strand break repair via homologous recombination|single-stranded DNA binding|nucleus|ATPase activity|protein stabilization|Shu complex SWT1 15.7673681975443 12.1459238444562 19.3888125506324 1.59632258516771 0.674752221106181 0.376148226791054 1 0.022133 0.0762152 0.0806157 0.0650549 GeneID:54823,Genbank:NM_001105518.1,HGNC:HGNC:16785 SWT1, RNA endoribonuclease homolog GO:0005634,GO:0006351 nucleus|transcription, DNA-templated SYAP1 934.36812002756 928.571965145301 940.164274909819 1.01248401868638 0.0178991362996097 0.910244293422651 1 10.1071 10.458 10.4602 10.2442 GeneID:94056,Genbank:NM_032796.3,HGNC:HGNC:16273 synapse associated protein 1 GO:0005654,GO:0005794,GO:0005829,GO:0030424,GO:0030425,GO:0030426,GO:0031234,GO:0032869,GO:0036120,GO:0038203,GO:0042734,GO:0043204,GO:0045211,GO:0045600,GO:0048471,GO:0070062,GO:0071364,GO:0071902,GO:0090073,GO:1990314 nucleoplasm|Golgi apparatus|cytosol|axon|dendrite|growth cone|extrinsic component of cytoplasmic side of plasma membrane|cellular response to insulin stimulus|cellular response to platelet-derived growth factor stimulus|TORC2 signaling|presynaptic membrane|perikaryon|postsynaptic membrane|positive regulation of fat cell differentiation|perinuclear region of cytoplasm|extracellular exosome|cellular response to epidermal growth factor stimulus|positive regulation of protein serine/threonine kinase activity|positive regulation of protein homodimerization activity|cellular response to insulin-like growth factor stimulus SYBU 228.965332859774 233.05819691933 224.872468800219 0.964876892435823 -0.0515832126125205 0.826093992569123 1 1.15461 1.03132 1.13303 1.01998 GeneID:55638,Genbank:NM_001330596.1,HGNC:HGNC:26011,MIM:611568 syntabulin GO:0000139,GO:0005874,GO:0008017,GO:0016021,GO:0017075,GO:0019894,GO:0019896,GO:0031410,GO:0035774,GO:0043231,GO:0060025,GO:0060074,GO:0097433,GO:1904115,GO:1990048 Golgi membrane|microtubule|microtubule binding|integral component of membrane|syntaxin-1 binding|kinesin binding|axonal transport of mitochondrion|cytoplasmic vesicle|positive regulation of insulin secretion involved in cellular response to glucose stimulus|intracellular membrane-bounded organelle|regulation of synaptic activity|synapse maturation|dense body|axon cytoplasm|anterograde neuronal dense core vesicle transport SYCE1L 2.74818133089044 2.10436443188427 3.3919982298966 1.61188726558135 0.688750846177228 0.791575892389204 1 0 0 0 0.146338 GeneID:100130958,Genbank:NM_001129979.2,HGNC:HGNC:37236 synaptonemal complex central element protein 1 like GO:0000795,GO:0007130,GO:0045111 synaptonemal complex|synaptonemal complex assembly|intermediate filament cytoskeleton SYCE2 40.6477225314122 35.2557149756063 46.0397300872181 1.30587991532928 0.385022237217999 0.40574118864769 1 0.419591 0.426656 0.579639 0.557862 GeneID:256126,Genbank:XM_011527882.2,HGNC:HGNC:27411,MIM:611487 synaptonemal complex central element protein 2 GO:0000801,GO:0005634,GO:0007130,GO:0051301 central element|nucleus|synaptonemal complex assembly|cell division SYCE3 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0.0572916 0 GeneID:644186,Genbank:NM_001123225.2,HGNC:HGNC:35245,MIM:615775 synaptonemal complex central element protein 3 GO:0000801,GO:0005634,GO:0005694,GO:0007130,GO:0007131,GO:0007283,GO:0043065,GO:0051301 central element|nucleus|chromosome|synaptonemal complex assembly|reciprocal meiotic recombination|spermatogenesis|positive regulation of apoptotic process|cell division SYCP2 1.45520490776151 0 2.91040981552302 Inf Inf 0.415774444330224 1 0 0 0.0210279 0 GeneID:10388,Genbank:XM_011528493.2,HGNC:HGNC:11490,MIM:604105 synaptonemal complex protein 2 GO:0000795,GO:0000800,GO:0003677,GO:0005634,GO:0007130,GO:0007140,GO:0007143,GO:0009566,GO:0043066,GO:0046982,GO:0048808,GO:0051301 synaptonemal complex|lateral element|DNA binding|nucleus|synaptonemal complex assembly|male meiotic nuclear division|female meiotic nuclear division|fertilization|negative regulation of apoptotic process|protein heterodimerization activity|male genitalia morphogenesis|cell division SYCP2L 5.23699340264851 5.14084539299833 5.33314141229868 1.03740552469488 0.0529799578954221 1 1 0.0475309 0 0.0571625 0.0319234 GeneID:221711,Genbank:NM_001040274.2,HGNC:HGNC:21537,MIM:616799 synaptonemal complex protein 2 like GO:0000780,GO:0005654 condensed nuclear chromosome, centromeric region|nucleoplasm SYCP3 9.2566395690105 9.7916193840393 8.72165975398169 0.890726999478586 -0.166944769592614 0.926318118571681 1 0.0270972 0 0 0.0973017 GeneID:50511,Genbank:XM_011538421.3,HGNC:HGNC:18130,MIM:604759 synaptonemal complex protein 3 GO:0000775,GO:0000795,GO:0000800,GO:0003677,GO:0005634,GO:0007141,GO:0035093,GO:0051301,GO:0051321 chromosome, centromeric region|synaptonemal complex|lateral element|DNA binding|nucleus|male meiosis I|spermatogenesis, exchange of chromosomal proteins|cell division|meiotic cell cycle hsa03440 Homologous recombination SYDE1 1961.77975136451 2074.26314466622 1849.29635806281 0.891543757511243 -0.165622486947077 0.228326380195596 1 28.4412 29.8224 26.17 26.7177 GeneID:85360,Genbank:NM_033025.5,HGNC:HGNC:25824,MIM:617377 synapse defective Rho GTPase homolog 1 GO:0005096,GO:0005737,GO:0005829,GO:0007165,GO:0043087,GO:0051056,GO:0051493,GO:0090630,GO:1901165 GTPase activator activity|cytoplasm|cytosol|signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction|regulation of cytoskeleton organization|activation of GTPase activity|positive regulation of trophoblast cell migration SYDE2 39.2335336633355 47.4496650947474 31.0174022319236 0.653690646077018 -0.61332004166963 0.173644162658293 1 0.162729 0.258588 0.156697 0.125732 GeneID:84144,Genbank:XM_017002484.2,HGNC:HGNC:25841 synapse defective Rho GTPase homolog 2 GO:0005096,GO:0005737,GO:0005829,GO:0007165,GO:0043087,GO:0051056,GO:0090630 GTPase activator activity|cytoplasm|cytosol|signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction|activation of GTPase activity SYF2 556.588272035559 577.139037017207 536.037507053911 0.928784006405598 -0.10658496557578 0.549719683324721 1 11.5472 10.7612 11.5323 9.238 GeneID:25949,Genbank:NM_207170.3,HGNC:HGNC:19824,MIM:607090 SYF2 pre-mRNA splicing factor GO:0000398,GO:0000974,GO:0001701,GO:0003723,GO:0005634,GO:0005654,GO:0007095,GO:0007369,GO:0008284,GO:0016607,GO:0048568,GO:0071013,GO:0071014 mRNA splicing, via spliceosome|Prp19 complex|in utero embryonic development|RNA binding|nucleus|nucleoplasm|mitotic G2 DNA damage checkpoint|gastrulation|positive regulation of cell proliferation|nuclear speck|embryonic organ development|catalytic step 2 spliceosome|post-mRNA release spliceosomal complex hsa03040 Spliceosome SYMPK 2128.84912297413 2127.40156148571 2130.29668446254 1.00136087282685 0.00196198977188576 0.988433562565878 1 13.7784 15.0061 13.8194 15.1169 GeneID:8189,Genbank:NM_004819.2,HGNC:HGNC:22935,MIM:602388 symplekin GO:0000398,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0005923,GO:0006369,GO:0006378,GO:0006406,GO:0007155,GO:0031124,GO:0035307,GO:0097165 mRNA splicing, via spliceosome|nucleoplasm|cytoplasm|cytosol|cytoskeleton|plasma membrane|bicellular tight junction|termination of RNA polymerase II transcription|mRNA polyadenylation|mRNA export from nucleus|cell adhesion|mRNA 3'-end processing|positive regulation of protein dephosphorylation|nuclear stress granule hsa03015,hsa04530 mRNA surveillance pathway|Tight junction SYN1 15.4778005364154 18.3629645907392 12.5926364820917 0.685762716573685 -0.544218624670989 0.555806555028276 1 0.217206 0.252512 0.0402179 0.238519 GeneID:6853,Genbank:NM_133499.2,HGNC:HGNC:11494,MIM:313440 synapsin I GO:0000795,GO:0003779,GO:0003824,GO:0005215,GO:0005524,GO:0005794,GO:0005829,GO:0005856,GO:0007268,GO:0007269,GO:0008021,GO:0014069,GO:0019901,GO:0030054,GO:0030425,GO:0043195,GO:0043209,GO:0046928,GO:0048306,GO:0048786,GO:0097091,GO:0098993,GO:2000300 synaptonemal complex|actin binding|catalytic activity|transporter activity|ATP binding|Golgi apparatus|cytosol|cytoskeleton|chemical synaptic transmission|neurotransmitter secretion|synaptic vesicle|postsynaptic density|protein kinase binding|cell junction|dendrite|terminal bouton|myelin sheath|regulation of neurotransmitter secretion|calcium-dependent protein binding|presynaptic active zone|synaptic vesicle clustering|anchored component of synaptic vesicle membrane|regulation of synaptic vesicle exocytosis SYN2 2.51652335039063 4.06465003971372 0.968396661067546 0.238248471973186 -2.06946113356967 0.367482900601058 1 0.0160511 0.00985751 0 0 GeneID:6854,Genbank:NM_133625.4,HGNC:HGNC:11495,MIM:600755 synapsin II GO:0003824,GO:0005524,GO:0007268,GO:0007269,GO:0030054,GO:0030672,GO:0045202 catalytic activity|ATP binding|chemical synaptic transmission|neurotransmitter secretion|cell junction|synaptic vesicle membrane|synapse SYN3 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.00358529 0.00330781 0 0 GeneID:8224,Genbank:XM_017028964.2,HGNC:HGNC:11496,MIM:602705 synapsin III GO:0003824,GO:0005524,GO:0007269,GO:0008021,GO:0014069,GO:0030054,GO:0030672,GO:0032228 catalytic activity|ATP binding|neurotransmitter secretion|synaptic vesicle|postsynaptic density|cell junction|synaptic vesicle membrane|regulation of synaptic transmission, GABAergic SYNC 677.41419739172 612.384943337706 742.443451445734 1.21238031653614 0.277842334712432 0.0838497009244201 0.963076417285947 3.08001 2.82343 3.79546 3.56971 GeneID:81493,Genbank:NM_001161708.1,HGNC:HGNC:28897,MIM:611750 syncoilin, intermediate filament protein GO:0005198,GO:0005829,GO:0005882,GO:0030018,GO:0031594,GO:0042383,GO:0045103,GO:0048471 structural molecule activity|cytosol|intermediate filament|Z disc|neuromuscular junction|sarcolemma|intermediate filament-based process|perinuclear region of cytoplasm SYNCRIP 5364.49866577734 5774.82762763832 4954.16970391636 0.857890490134408 -0.221134595674514 0.158597149533125 1 25.82 22.9106 23.1389 19.2052 GeneID:10492,Genbank:NM_001159677.1,HGNC:HGNC:16918,MIM:616686 synaptotagmin binding cytoplasmic RNA interacting protein GO:0000398,GO:0001649,GO:0003723,GO:0005634,GO:0005654,GO:0005783,GO:0006396,GO:0008143,GO:0008380,GO:0016020,GO:0016032,GO:0017148,GO:0030529,GO:0070934,GO:0070937,GO:0071013,GO:0071204,GO:0071346,GO:0097452 mRNA splicing, via spliceosome|osteoblast differentiation|RNA binding|nucleus|nucleoplasm|endoplasmic reticulum|RNA processing|poly(A) binding|RNA splicing|membrane|viral process|negative regulation of translation|intracellular ribonucleoprotein complex|CRD-mediated mRNA stabilization|CRD-mediated mRNA stability complex|catalytic step 2 spliceosome|histone pre-mRNA 3'end processing complex|cellular response to interferon-gamma|GAIT complex SYNDIG1 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.00843614 GeneID:79953,Genbank:NM_001323606.1,HGNC:HGNC:15885,MIM:614311 synapse differentiation inducing 1 GO:0005887,GO:0006886,GO:0009607,GO:0014069,GO:0030054,GO:0031901,GO:0035254,GO:0042803,GO:0043197,GO:0043198,GO:0043231,GO:0044297,GO:0045211,GO:0051965,GO:0060076,GO:0097091,GO:0098793 integral component of plasma membrane|intracellular protein transport|response to biotic stimulus|postsynaptic density|cell junction|early endosome membrane|glutamate receptor binding|protein homodimerization activity|dendritic spine|dendritic shaft|intracellular membrane-bounded organelle|cell body|postsynaptic membrane|positive regulation of synapse assembly|excitatory synapse|synaptic vesicle clustering|presynapse SYNDIG1L 6.71860463096249 6.169014471598 7.26819479032697 1.17817762039457 0.236557054232322 0.899939826317516 1 0.0485534 0.0439022 0.0304035 0.0640485 GeneID:646658,Genbank:XM_017021600.1,HGNC:HGNC:32388,MIM:609999 synapse differentiation inducing 1 like GO:0005794,GO:0009607,GO:0016021 Golgi apparatus|response to biotic stimulus|integral component of membrane SYNE1 674.962699130315 655.28969564589 694.63570261474 1.06004368332096 0.084123718007315 0.821701923025136 1 0.585985 0.569632 0.793343 0.429358 GeneID:23345,Genbank:NM_182961.3,HGNC:HGNC:17089,MIM:608441 spectrin repeat containing nuclear envelope protein 1 SYNE2 450.436305279692 396.209688148135 504.662922411249 1.27372686107202 0.349055938171375 0.553215189388424 1 0.468541 0.400839 0.770131 0.328192 GeneID:23224,Genbank:XM_011536576.2,HGNC:HGNC:17084,MIM:608442 spectrin repeat containing nuclear envelope protein 2 GO:0003779,GO:0005634,GO:0005635,GO:0005640,GO:0005654,GO:0005737,GO:0005739,GO:0005925,GO:0006998,GO:0007097,GO:0007163,GO:0010761,GO:0016021,GO:0016235,GO:0016529,GO:0021817,GO:0030018,GO:0030335,GO:0031022,GO:0031258,GO:0031527,GO:0031965,GO:0031981,GO:0033017,GO:0034504,GO:0034993,GO:0045111,GO:0051015,GO:0051642,GO:0070062,GO:0090286,GO:1902017 actin binding|nucleus|nuclear envelope|nuclear outer membrane|nucleoplasm|cytoplasm|mitochondrion|focal adhesion|nuclear envelope organization|nuclear migration|establishment or maintenance of cell polarity|fibroblast migration|integral component of membrane|aggresome|sarcoplasmic reticulum|nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration|Z disc|positive regulation of cell migration|nuclear migration along microfilament|lamellipodium membrane|filopodium membrane|nuclear membrane|nuclear lumen|sarcoplasmic reticulum membrane|protein localization to nucleus|LINC complex|intermediate filament cytoskeleton|actin filament binding|centrosome localization|extracellular exosome|cytoskeletal anchoring at nuclear membrane|regulation of cilium assembly SYNE3 70.0124033787502 72.6638206577817 67.3609860997186 0.92702235431526 -0.109323966316039 0.762675794623297 1 0.145557 0.159919 0.150434 0.164549 GeneID:161176,Genbank:NM_152592.4,HGNC:HGNC:19861,MIM:610861 spectrin repeat containing nuclear envelope family member 3 GO:0005635,GO:0005640,GO:0005791,GO:0007010,GO:0008360,GO:0016020,GO:0016021,GO:0031965,GO:0034993,GO:0051015,GO:0090150,GO:0090286 nuclear envelope|nuclear outer membrane|rough endoplasmic reticulum|cytoskeleton organization|regulation of cell shape|membrane|integral component of membrane|nuclear membrane|LINC complex|actin filament binding|establishment of protein localization to membrane|cytoskeletal anchoring at nuclear membrane SYNE4 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0309043 0 0 GeneID:163183,Genbank:NM_001297735.2,HGNC:HGNC:26703,MIM:615535 spectrin repeat containing nuclear envelope family member 4 GO:0031309,GO:0034993,GO:0045198 integral component of nuclear outer membrane|LINC complex|establishment of epithelial cell apical/basal polarity SYNGAP1 281.155085944733 270.533946186406 291.776225703059 1.07851983019542 0.109052702841974 0.614378094126896 1 1.44927 1.52766 1.89814 1.41521 GeneID:8831,Genbank:NM_006772.2,HGNC:HGNC:11497,MIM:603384 synaptic Ras GTPase activating protein 1 GO:0005096,GO:0005737,GO:0007265,GO:0007389,GO:0008542,GO:0014069,GO:0016020,GO:0016358,GO:0017124,GO:0019901,GO:0030054,GO:0031235,GO:0043113,GO:0043198,GO:0043408,GO:0043524,GO:0045202,GO:0046580,GO:0048167,GO:0048169,GO:0050771,GO:0050803 GTPase activator activity|cytoplasm|Ras protein signal transduction|pattern specification process|visual learning|postsynaptic density|membrane|dendrite development|SH3 domain binding|protein kinase binding|cell junction|intrinsic component of the cytoplasmic side of the plasma membrane|receptor clustering|dendritic shaft|regulation of MAPK cascade|negative regulation of neuron apoptotic process|synapse|negative regulation of Ras protein signal transduction|regulation of synaptic plasticity|regulation of long-term neuronal synaptic plasticity|negative regulation of axonogenesis|regulation of synapse structure or activity hsa04014 Ras signaling pathway SYNGR1 344.166204202312 322.452088828563 365.880319576061 1.13468118908849 0.182287001013536 0.366296378349039 1 1.87439 2.17904 2.3932 2.39054 GeneID:9145,Genbank:NM_004711.4,HGNC:HGNC:11498,MIM:603925 synaptogyrin 1 GO:0005886,GO:0006605,GO:0016021,GO:0030054,GO:0030672,GO:0031594,GO:0035577,GO:0042470,GO:0043195,GO:0043312,GO:0045055,GO:0048169,GO:0048172,GO:0048499,GO:1990830 plasma membrane|protein targeting|integral component of membrane|cell junction|synaptic vesicle membrane|neuromuscular junction|azurophil granule membrane|melanosome|terminal bouton|neutrophil degranulation|regulated exocytosis|regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|synaptic vesicle membrane organization|cellular response to leukemia inhibitory factor SYNGR2 1952.87829644687 2018.17550778073 1887.581085113 0.935290849500335 -0.0965130219919784 0.471547803048642 1 50.4548 55.2444 50.304 50.9375 GeneID:9144,Genbank:NM_004710.4,HGNC:HGNC:11499,MIM:603926 synaptogyrin 2 GO:0005811,GO:0016021,GO:0030054,GO:0030672,GO:0031594,GO:0045055,GO:0048499,GO:0070062 lipid droplet|integral component of membrane|cell junction|synaptic vesicle membrane|neuromuscular junction|regulated exocytosis|synaptic vesicle membrane organization|extracellular exosome SYNGR3 111.01338238319 105.719118652134 116.307646114246 1.10015716738004 0.137709640479707 0.656564056356883 1 2.72148 3.09057 3.21883 3.36393 GeneID:9143,Genbank:NM_004209.5,HGNC:HGNC:11501,MIM:603927 synaptogyrin 3 GO:0008021,GO:0016021,GO:0021762,GO:0030054,GO:0030672,GO:0031594,GO:0032411,GO:0042169,GO:0045055,GO:0047485 synaptic vesicle|integral component of membrane|substantia nigra development|cell junction|synaptic vesicle membrane|neuromuscular junction|positive regulation of transporter activity|SH2 domain binding|regulated exocytosis|protein N-terminus binding SYNGR4 3.02310324063518 3.6226049124413 2.42360156882906 0.669021775050752 -0.579874927000458 0.839804273845197 1 0.0633854 0.0566227 0.0395731 0.0369373 GeneID:23546,Genbank:XM_005258693.3,HGNC:HGNC:11502,MIM:608373 synaptogyrin 4 GO:0016021,GO:0030672,GO:0031594 integral component of membrane|synaptic vesicle membrane|neuromuscular junction SYNJ1 189.001753100775 196.726286590439 181.277219611111 0.921469228911485 -0.117992104872958 0.625043386874819 1 0.710908 0.70173 0.7539 0.509274 GeneID:8867,Genbank:NM_003895.3,HGNC:HGNC:11503,MIM:604297 synaptojanin 1 GO:0003723,GO:0004438,GO:0004439,GO:0005829,GO:0006661,GO:0006836,GO:0007612,GO:0012506,GO:0016082,GO:0016191,GO:0030117,GO:0030132,GO:0034595,GO:0034596,GO:0043195,GO:0043647,GO:0043812,GO:0043813,GO:0046488,GO:0046855,GO:0046856,GO:0048471,GO:0048488,GO:0048489,GO:0052629,GO:0052658,GO:0052659,GO:0061024,GO:0097060,GO:0098793,GO:1904980 RNA binding|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|cytosol|phosphatidylinositol biosynthetic process|neurotransmitter transport|learning|vesicle membrane|synaptic vesicle priming|synaptic vesicle uncoating|membrane coat|clathrin coat of coated pit|phosphatidylinositol phosphate 5-phosphatase activity|phosphatidylinositol phosphate 4-phosphatase activity|terminal bouton|inositol phosphate metabolic process|phosphatidylinositol-4-phosphate phosphatase activity|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol metabolic process|inositol phosphate dephosphorylation|phosphatidylinositol dephosphorylation|perinuclear region of cytoplasm|synaptic vesicle endocytosis|synaptic vesicle transport|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|membrane organization|synaptic membrane|presynapse|positive regulation of endosome organization hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system SYNJ2 2639.11789857471 3170.32756607133 2107.90823107809 0.664886573121595 -0.588819851044015 8.12025536370896e-05 0.0207690271445571 9.46614 9.20021 7.3193 5.05662 GeneID:8871,Genbank:XM_006715592.3,HGNC:HGNC:11504,MIM:609410 synaptojanin 2 GO:0003723,GO:0004438,GO:0004439,GO:0005829,GO:0005856,GO:0005886,GO:0006661,GO:0030424,GO:0034596,GO:0043813,GO:0045121,GO:0046856,GO:0052629,GO:0061024 RNA binding|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|cytosol|cytoskeleton|plasma membrane|phosphatidylinositol biosynthetic process|axon|phosphatidylinositol phosphate 4-phosphatase activity|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|membrane raft|phosphatidylinositol dephosphorylation|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|membrane organization hsa00562,hsa04070 Inositol phosphate metabolism|Phosphatidylinositol signaling system SYNJ2BP 381.000013451479 352.460080205838 409.53994669712 1.16194703938655 0.216544313358949 0.238051220938287 1 2.31029 2.20032 2.84329 2.32769 GeneID:55333,Genbank:NM_018373.2,HGNC:HGNC:18955,MIM:609411 synaptojanin 2 binding protein GO:0001937,GO:0005739,GO:0006605,GO:0007266,GO:0008022,GO:0008593,GO:0010596,GO:0016525,GO:0030100,GO:0031307,GO:0048312,GO:0070373,GO:1903671 negative regulation of endothelial cell proliferation|mitochondrion|protein targeting|Rho protein signal transduction|protein C-terminus binding|regulation of Notch signaling pathway|negative regulation of endothelial cell migration|negative regulation of angiogenesis|regulation of endocytosis|integral component of mitochondrial outer membrane|intracellular distribution of mitochondria|negative regulation of ERK1 and ERK2 cascade|negative regulation of sprouting angiogenesis SYNM 1596.59522888718 1470.7914711097 1722.39898666466 1.17106946871614 0.22782666012571 0.109672902528664 1 7.3744 6.98949 8.92706 8.11489 GeneID:23336,Genbank:XM_017022035.1,HGNC:HGNC:24466,MIM:606087 synemin GO:0005200,GO:0005882,GO:0005912,GO:0008307,GO:0017166,GO:0019215,GO:0031443,GO:0042383,GO:0043034,GO:0045104,GO:0060053 structural constituent of cytoskeleton|intermediate filament|adherens junction|structural constituent of muscle|vinculin binding|intermediate filament binding|fast-twitch skeletal muscle fiber contraction|sarcolemma|costamere|intermediate filament cytoskeleton organization|neurofilament cytoskeleton SYNPO 1154.47747228612 1346.6045436632 962.350400909033 0.714649601798557 -0.48469204412491 0.00838303268615794 0.356525902221039 5.22832 4.99336 3.24648 4.12035 GeneID:11346,Genbank:XM_006714755.3,HGNC:HGNC:30672,MIM:608155 synaptopodin GO:0003779,GO:0005634,GO:0005923,GO:0008542,GO:0014069,GO:0015629,GO:0030018,GO:0032233,GO:0043197,GO:0043204,GO:0045211,GO:0048169,GO:0051492,GO:0097444,GO:0098886,GO:1905355 actin binding|nucleus|bicellular tight junction|visual learning|postsynaptic density|actin cytoskeleton|Z disc|positive regulation of actin filament bundle assembly|dendritic spine|perikaryon|postsynaptic membrane|regulation of long-term neuronal synaptic plasticity|regulation of stress fiber assembly|spine apparatus|modification of dendritic spine|spine apparatus assembly hsa04530 Tight junction SYNPO2 8.13002475783095 6.56303332418548 9.69701619147641 1.47752048671487 0.563178134380496 0.645535223731189 1 0.0113348 0.0243165 0.0408313 0.0126862 GeneID:171024,Genbank:NM_001286754.1,HGNC:HGNC:17732 synaptopodin 2 GO:0000045,GO:0001725,GO:0003779,GO:0005634,GO:0005829,GO:0005925,GO:0030018,GO:0030335,GO:0031005,GO:0032233,GO:0051371,GO:0051393,GO:0071889,GO:2000298 autophagosome assembly|stress fiber|actin binding|nucleus|cytosol|focal adhesion|Z disc|positive regulation of cell migration|filamin binding|positive regulation of actin filament bundle assembly|muscle alpha-actinin binding|alpha-actinin binding|14-3-3 protein binding|regulation of Rho-dependent protein serine/threonine kinase activity SYNPO2L 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.00633248 0.00659995 0 GeneID:79933,Genbank:NM_001114133.2,HGNC:HGNC:23532 synaptopodin 2 like GO:0003779,GO:0005634,GO:0005654,GO:0005829,GO:0015629,GO:0016607,GO:0030018,GO:0030054,GO:0032233 actin binding|nucleus|nucleoplasm|cytosol|actin cytoskeleton|nuclear speck|Z disc|cell junction|positive regulation of actin filament bundle assembly SYNPR 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0089016 0 0 0 GeneID:132204,Genbank:XM_017005731.1,HGNC:HGNC:16507 synaptoporin GO:0030054,GO:0030285,GO:0043005 cell junction|integral component of synaptic vesicle membrane|neuron projection SYNRG 1136.3526822591 1113.87272201156 1158.83264250665 1.0403636067269 0.057087837925886 0.697740949761622 1 4.57688 4.38082 5.28226 4.15287 GeneID:11276,Genbank:NM_001163545.2,HGNC:HGNC:557,MIM:607291 synergin gamma GO:0005737,GO:0005794,GO:0006886,GO:0006897,GO:0030121 cytoplasm|Golgi apparatus|intracellular protein transport|endocytosis|AP-1 adaptor complex SYP 11.9352830375586 12.2419763938261 11.6285896812911 0.949894796983571 -0.074160354364346 0.977256516765075 1 0.141885 0.205173 0.133249 0.233886 GeneID:6855,Genbank:NM_003179.2,HGNC:HGNC:11506,MIM:313475 synaptophysin SYPL1 3392.88480407684 3517.20068775348 3268.56892040021 0.929309758121286 -0.105768538086828 0.527111795491839 1 83.8255 73.5918 81.6369 66.2738 GeneID:6856,Genbank:NM_006754.3,HGNC:HGNC:11507,MIM:616665 synaptophysin like 1 GO:0005887,GO:0007268,GO:0016021,GO:0030141,GO:0030285,GO:0042470,GO:0070062 integral component of plasma membrane|chemical synaptic transmission|integral component of membrane|secretory granule|integral component of synaptic vesicle membrane|melanosome|extracellular exosome SYPL2 72.8940410230267 82.3015525626583 63.4865294833951 0.771389208424242 -0.374469131785262 0.281549595122806 1 0.656016 0.781616 0.953316 0.59454 GeneID:284612,Genbank:NM_001040709.1,HGNC:HGNC:27638 synaptophysin like 2 GO:0006874,GO:0021762,GO:0030285 cellular calcium ion homeostasis|substantia nigra development|integral component of synaptic vesicle membrane SYS1 619.454800768632 586.067200457773 652.842401079491 1.1139377883109 0.155668662658579 0.365304426239116 1 4.35855 5.02776 5.96805 4.79644 GeneID:90196,Genbank:NM_001197129.1,HGNC:HGNC:16162,MIM:612979 SYS1, golgi trafficking protein GO:0005634,GO:0005737,GO:0030308,GO:0035556 nucleus|cytoplasm|negative regulation of cell growth|intracellular signal transduction SYT1 239.176545539845 242.282292661403 236.070798418287 0.974362574437924 -0.0374693749330939 0.954811608328564 1 1.87501 1.47904 2.10495 1.16488 GeneID:6857,Genbank:NM_001135805.1,HGNC:HGNC:11509,MIM:185605 synaptotagmin 1 GO:0000149,GO:0001786,GO:0005509,GO:0005513,GO:0005516,GO:0005544,GO:0005545,GO:0005546,GO:0005794,GO:0005829,GO:0005886,GO:0006906,GO:0007268,GO:0007269,GO:0007420,GO:0008021,GO:0008022,GO:0014047,GO:0014059,GO:0017075,GO:0017157,GO:0017158,GO:0030054,GO:0030276,GO:0030285,GO:0030348,GO:0030665,GO:0030672,GO:0031045,GO:0031201,GO:0031340,GO:0042584,GO:0042734,GO:0042802,GO:0043005,GO:0043195,GO:0045956,GO:0046982,GO:0048278,GO:0048306,GO:0048488,GO:0048791,GO:0050750,GO:0050806,GO:0051260,GO:0051291,GO:0051966,GO:0060076,GO:0060201,GO:0060203,GO:0061024,GO:0061202,GO:0070083,GO:0071277,GO:0098746,GO:1903305,GO:1903861 SNARE binding|phosphatidylserine binding|calcium ion binding|detection of calcium ion|calmodulin binding|calcium-dependent phospholipid binding|1-phosphatidylinositol binding|phosphatidylinositol-4,5-bisphosphate binding|Golgi apparatus|cytosol|plasma membrane|vesicle fusion|chemical synaptic transmission|neurotransmitter secretion|brain development|synaptic vesicle|protein C-terminus binding|glutamate secretion|regulation of dopamine secretion|syntaxin-1 binding|regulation of exocytosis|regulation of calcium ion-dependent exocytosis|cell junction|clathrin binding|integral component of synaptic vesicle membrane|syntaxin-3 binding|clathrin-coated vesicle membrane|synaptic vesicle membrane|dense core granule|SNARE complex|positive regulation of vesicle fusion|chromaffin granule membrane|presynaptic membrane|identical protein binding|neuron projection|terminal bouton|positive regulation of calcium ion-dependent exocytosis|protein heterodimerization activity|vesicle docking|calcium-dependent protein binding|synaptic vesicle endocytosis|calcium ion-regulated exocytosis of neurotransmitter|low-density lipoprotein particle receptor binding|positive regulation of synaptic transmission|protein homooligomerization|protein heterooligomerization|regulation of synaptic transmission, glutamatergic|excitatory synapse|clathrin-sculpted acetylcholine transport vesicle membrane|clathrin-sculpted glutamate transport vesicle membrane|membrane organization|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin-sculpted monoamine transport vesicle membrane|cellular response to calcium ion|fast, calcium ion-dependent exocytosis of neurotransmitter|regulation of regulated secretory pathway|positive regulation of dendrite extension hsa04721 Synaptic vesicle cycle SYT11 4402.17412627676 4012.82046926151 4791.527783292 1.19405485991597 0.255869121619916 0.123886863285915 1 27.7572 26.6161 37.4265 28.3768 GeneID:23208,Genbank:NM_152280.4,HGNC:HGNC:19239,MIM:608741 synaptotagmin 11 GO:0001778,GO:0001891,GO:0005764,GO:0005886,GO:0005887,GO:0006906,GO:0008021,GO:0014069,GO:0019905,GO:0030054,GO:0030276,GO:0030424,GO:0030672,GO:0031369,GO:0031625,GO:0032009,GO:0042803,GO:0043005,GO:0043195,GO:0043197,GO:0044297,GO:0045335,GO:0046872,GO:0046929,GO:0048471,GO:0048487,GO:0048787,GO:0048791,GO:0050765,GO:0051289,GO:0055037,GO:0060076,GO:0060077,GO:0098793,GO:1900165,GO:1900186,GO:1900243,GO:1900424,GO:1904468,GO:1905154,GO:1905162,GO:1905171,GO:1905469,GO:1990927 plasma membrane repair|phagocytic cup|lysosome|plasma membrane|integral component of plasma membrane|vesicle fusion|synaptic vesicle|postsynaptic density|syntaxin binding|cell junction|clathrin binding|axon|synaptic vesicle membrane|translation initiation factor binding|ubiquitin protein ligase binding|early phagosome|protein homodimerization activity|neuron projection|terminal bouton|dendritic spine|cell body|phagocytic vesicle|metal ion binding|negative regulation of neurotransmitter secretion|perinuclear region of cytoplasm|beta-tubulin binding|presynaptic active zone membrane|calcium ion-regulated exocytosis of neurotransmitter|negative regulation of phagocytosis|protein homotetramerization|recycling endosome|excitatory synapse|inhibitory synapse|presynapse|negative regulation of interleukin-6 secretion|negative regulation of clathrin-dependent endocytosis|negative regulation of synaptic vesicle endocytosis|regulation of defense response to bacterium|negative regulation of tumor necrosis factor secretion|negative regulation of membrane invagination|regulation of phagosome maturation|positive regulation of protein localization to phagocytic vesicle|negative regulation of clathrin-coated pit assembly|calcium ion regulated lysosome exocytosis SYT12 191.687200291235 159.472068387426 223.902332195045 1.40402224953331 0.489565798204464 0.0347998196372593 0.730476947982104 1.08606 1.08663 1.61205 1.45668 GeneID:91683,Genbank:XM_011545346.3,HGNC:HGNC:18381,MIM:606436 synaptotagmin 12 GO:0005509,GO:0005544,GO:0005886,GO:0006906,GO:0016021,GO:0017158,GO:0019905,GO:0030054,GO:0030276,GO:0030672,GO:0046928,GO:0048791,GO:0048792,GO:0060291 calcium ion binding|calcium-dependent phospholipid binding|plasma membrane|vesicle fusion|integral component of membrane|regulation of calcium ion-dependent exocytosis|syntaxin binding|cell junction|clathrin binding|synaptic vesicle membrane|regulation of neurotransmitter secretion|calcium ion-regulated exocytosis of neurotransmitter|spontaneous exocytosis of neurotransmitter|long-term synaptic potentiation SYT13 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00857386 0 0 0 GeneID:57586,Genbank:NM_020826.2,HGNC:HGNC:14962,MIM:607716 synaptotagmin 13 GO:0005509,GO:0005544,GO:0005886,GO:0005887,GO:0006906,GO:0017158,GO:0019905,GO:0030133,GO:0030276,GO:0043231,GO:0048791,GO:0098793 calcium ion binding|calcium-dependent phospholipid binding|plasma membrane|integral component of plasma membrane|vesicle fusion|regulation of calcium ion-dependent exocytosis|syntaxin binding|transport vesicle|clathrin binding|intracellular membrane-bounded organelle|calcium ion-regulated exocytosis of neurotransmitter|presynapse SYT14 57.7729543469988 58.3556974516483 57.1902112423492 0.980027893415809 -0.0291052832921909 0.985209354596714 1 0.169096 0.122993 0.167805 0.135775 GeneID:255928,Genbank:XM_017000935.2,HGNC:HGNC:23143,MIM:610949 synaptotagmin 14 GO:0005509,GO:0005886,GO:0006906,GO:0016021,GO:0019905,GO:0030276 calcium ion binding|plasma membrane|vesicle fusion|integral component of membrane|syntaxin binding|clathrin binding SYT16 4.95826498513857 3.13253351048394 6.7839964597932 2.16565806465871 1.11480547408044 0.43625808537453 1 0.00810486 0.00523447 0.0156931 0.0170367 GeneID:83851,Genbank:XM_017021698.1,HGNC:HGNC:23142,MIM:610950 synaptotagmin 16 GO:0005509,GO:0005543,GO:0005886,GO:0006887,GO:0006906,GO:0019905,GO:0030276,GO:0042803,GO:0046982 calcium ion binding|phospholipid binding|plasma membrane|exocytosis|vesicle fusion|syntaxin binding|clathrin binding|protein homodimerization activity|protein heterodimerization activity SYT17 5.95015393190048 7.05310472614284 4.84720313765811 0.687243891288273 -0.541105916790142 0.689557080127234 1 0.0267345 0.0810845 0.0420345 0.0157392 GeneID:51760,Genbank:NM_001330509.1,HGNC:HGNC:24119 synaptotagmin 17 GO:0005509,GO:0005544,GO:0005802,GO:0005886,GO:0006906,GO:0017158,GO:0019905,GO:0030276,GO:0048791,GO:0098793,GO:1903861 calcium ion binding|calcium-dependent phospholipid binding|trans-Golgi network|plasma membrane|vesicle fusion|regulation of calcium ion-dependent exocytosis|syntaxin binding|clathrin binding|calcium ion-regulated exocytosis of neurotransmitter|presynapse|positive regulation of dendrite extension SYT2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00302586 GeneID:127833,Genbank:XM_011509192.2,HGNC:HGNC:11510,MIM:600104 synaptotagmin 2 GO:0005509,GO:0005544,GO:0005886,GO:0006906,GO:0016021,GO:0017158,GO:0019905,GO:0030054,GO:0030276,GO:0030665,GO:0030672,GO:0042584,GO:0043533,GO:0048488,GO:0048791,GO:0061024,GO:1903861 calcium ion binding|calcium-dependent phospholipid binding|plasma membrane|vesicle fusion|integral component of membrane|regulation of calcium ion-dependent exocytosis|syntaxin binding|cell junction|clathrin binding|clathrin-coated vesicle membrane|synaptic vesicle membrane|chromaffin granule membrane|inositol 1,3,4,5 tetrakisphosphate binding|synaptic vesicle endocytosis|calcium ion-regulated exocytosis of neurotransmitter|membrane organization|positive regulation of dendrite extension SYT3 1.02316597922947 1.07619535328461 0.97013660517434 0.901450282435646 -0.149680169798226 1 1 0 0 0.0259248 0 GeneID:84258,Genbank:XM_011527391.3,HGNC:HGNC:11511,MIM:600327 synaptotagmin 3 GO:0005509,GO:0005544,GO:0005768,GO:0005886,GO:0006906,GO:0016021,GO:0017158,GO:0019905,GO:0030276,GO:0030658,GO:0048791,GO:0098793,GO:1903861 calcium ion binding|calcium-dependent phospholipid binding|endosome|plasma membrane|vesicle fusion|integral component of membrane|regulation of calcium ion-dependent exocytosis|syntaxin binding|clathrin binding|transport vesicle membrane|calcium ion-regulated exocytosis of neurotransmitter|presynapse|positive regulation of dendrite extension SYT4 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0198918 0 0 GeneID:6860,Genbank:NM_020783.3,HGNC:HGNC:11512,MIM:600103 synaptotagmin 4 GO:0001786,GO:0005886,GO:0006906,GO:0007420,GO:0007613,GO:0014049,GO:0014059,GO:0017075,GO:0019905,GO:0030054,GO:0030100,GO:0030173,GO:0030276,GO:0030285,GO:0030348,GO:0030424,GO:0030425,GO:0031339,GO:0032127,GO:0033604,GO:0042803,GO:0043025,GO:0043231,GO:0044306,GO:0045955,GO:0045956,GO:0046872,GO:0046929,GO:0046982,GO:0048174,GO:0048471,GO:0048791,GO:0050709,GO:0061782,GO:0061792,GO:0097449,GO:1903861,GO:1905433,GO:1990742 phosphatidylserine binding|plasma membrane|vesicle fusion|brain development|memory|positive regulation of glutamate secretion|regulation of dopamine secretion|syntaxin-1 binding|syntaxin binding|cell junction|regulation of endocytosis|integral component of Golgi membrane|clathrin binding|integral component of synaptic vesicle membrane|syntaxin-3 binding|axon|dendrite|negative regulation of vesicle fusion|dense core granule membrane|negative regulation of catecholamine secretion|protein homodimerization activity|neuronal cell body|intracellular membrane-bounded organelle|neuron projection terminus|negative regulation of calcium ion-dependent exocytosis|positive regulation of calcium ion-dependent exocytosis|metal ion binding|negative regulation of neurotransmitter secretion|protein heterodimerization activity|negative regulation of short-term neuronal synaptic plasticity|perinuclear region of cytoplasm|calcium ion-regulated exocytosis of neurotransmitter|negative regulation of protein secretion|vesicle fusion with vesicle|secretory granule maturation|astrocyte projection|positive regulation of dendrite extension|negative regulation of retrograde trans-synaptic signaling by neuropeptide|microvesicle SYT5 1.24038203510049 1.02816907859967 1.45259499160132 1.41279777989405 0.498554981013539 1 1 0 0.0143832 0 0.0144446 GeneID:6861,Genbank:XM_006723340.3,HGNC:HGNC:11513,MIM:600782 synaptotagmin 5 GO:0001786,GO:0005509,GO:0005544,GO:0005546,GO:0005886,GO:0006906,GO:0007268,GO:0016021,GO:0017158,GO:0019905,GO:0030054,GO:0030276,GO:0030672,GO:0031045,GO:0043025,GO:0046982,GO:0048471,GO:0048488,GO:0048791,GO:0055038,GO:1990769 phosphatidylserine binding|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|plasma membrane|vesicle fusion|chemical synaptic transmission|integral component of membrane|regulation of calcium ion-dependent exocytosis|syntaxin binding|cell junction|clathrin binding|synaptic vesicle membrane|dense core granule|neuronal cell body|protein heterodimerization activity|perinuclear region of cytoplasm|synaptic vesicle endocytosis|calcium ion-regulated exocytosis of neurotransmitter|recycling endosome membrane|proximal neuron projection SYT7 3.93760055559419 2.54640955915669 5.32879155203169 2.09266868829869 1.0653439219216 0.544835152147496 1 0.00730844 0.00967456 0.00680846 0.0255003 GeneID:9066,Genbank:NM_004200.3,HGNC:HGNC:11514,MIM:604146 synaptotagmin 7 GO:0001778,GO:0001786,GO:0005509,GO:0005516,GO:0005544,GO:0005546,GO:0005764,GO:0005765,GO:0005777,GO:0005778,GO:0005829,GO:0005886,GO:0006906,GO:0006909,GO:0008021,GO:0014059,GO:0016021,GO:0017158,GO:0019905,GO:0030054,GO:0030276,GO:0030425,GO:0030670,GO:0030672,GO:0031045,GO:0032009,GO:0036465,GO:0042734,GO:0043025,GO:0043195,GO:0045956,GO:0046850,GO:0048791,GO:0050764,GO:0050796,GO:0070062,GO:0070092,GO:0090119,GO:0090385,GO:1990926,GO:1990927 plasma membrane repair|phosphatidylserine binding|calcium ion binding|calmodulin binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|lysosome|lysosomal membrane|peroxisome|peroxisomal membrane|cytosol|plasma membrane|vesicle fusion|phagocytosis|synaptic vesicle|regulation of dopamine secretion|integral component of membrane|regulation of calcium ion-dependent exocytosis|syntaxin binding|cell junction|clathrin binding|dendrite|phagocytic vesicle membrane|synaptic vesicle membrane|dense core granule|early phagosome|synaptic vesicle recycling|presynaptic membrane|neuronal cell body|terminal bouton|positive regulation of calcium ion-dependent exocytosis|regulation of bone remodeling|calcium ion-regulated exocytosis of neurotransmitter|regulation of phagocytosis|regulation of insulin secretion|extracellular exosome|regulation of glucagon secretion|vesicle-mediated cholesterol transport|phagosome-lysosome fusion|short-term synaptic potentiation|calcium ion regulated lysosome exocytosis SYT8 8.58216194946517 5.53486424558581 11.6294596533445 2.10112825488345 1.0711642281875 0.312007791580019 1 0.0367701 0.0312932 0.084316 0.0631517 GeneID:90019,Genbank:XM_011520457.2,HGNC:HGNC:19264,MIM:607719 synaptotagmin 8 GO:0001669,GO:0005509,GO:0005544,GO:0005886,GO:0006906,GO:0007340,GO:0016021,GO:0017158,GO:0019905,GO:0030276,GO:0030672,GO:0048306,GO:0048488,GO:0048791 acrosomal vesicle|calcium ion binding|calcium-dependent phospholipid binding|plasma membrane|vesicle fusion|acrosome reaction|integral component of membrane|regulation of calcium ion-dependent exocytosis|syntaxin binding|clathrin binding|synaptic vesicle membrane|calcium-dependent protein binding|synaptic vesicle endocytosis|calcium ion-regulated exocytosis of neurotransmitter SYTL1 21.5648648575259 23.2636786103128 19.866051104739 0.853951408008724 -0.227774115696554 0.712500429568788 1 0.195715 0.375686 0.201605 0.335874 GeneID:84958,Genbank:NM_001193308.1,HGNC:HGNC:15584,MIM:608042 synaptotagmin like 1 GO:0005509,GO:0005544,GO:0005886,GO:0006886,GO:0006887,GO:0006906,GO:0017137,GO:0017158,GO:0019897,GO:0019905,GO:0030276,GO:0031528,GO:0042043,GO:0042470,GO:0048791,GO:0070062,GO:0070382,GO:0098793 calcium ion binding|calcium-dependent phospholipid binding|plasma membrane|intracellular protein transport|exocytosis|vesicle fusion|Rab GTPase binding|regulation of calcium ion-dependent exocytosis|extrinsic component of plasma membrane|syntaxin binding|clathrin binding|microvillus membrane|neurexin family protein binding|melanosome|calcium ion-regulated exocytosis of neurotransmitter|extracellular exosome|exocytic vesicle|presynapse SYTL2 62.5083838649677 69.7616098656146 55.2551578643209 0.7920568056093 -0.336324192067379 0.380023787325667 1 0.202807 0.162488 0.194969 0.12205 GeneID:54843,Genbank:NM_001289608.1,HGNC:HGNC:15585,MIM:612880 synaptotagmin like 2 GO:0001786,GO:0005509,GO:0005544,GO:0005546,GO:0005737,GO:0005886,GO:0006886,GO:0006887,GO:0006904,GO:0006906,GO:0010923,GO:0016020,GO:0016192,GO:0017137,GO:0019897,GO:0019902,GO:0019905,GO:0030276,GO:0042043,GO:0042470,GO:0070257,GO:0070382,GO:0072659 phosphatidylserine binding|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylinositol-4,5-bisphosphate binding|cytoplasm|plasma membrane|intracellular protein transport|exocytosis|vesicle docking involved in exocytosis|vesicle fusion|negative regulation of phosphatase activity|membrane|vesicle-mediated transport|Rab GTPase binding|extrinsic component of plasma membrane|phosphatase binding|syntaxin binding|clathrin binding|neurexin family protein binding|melanosome|positive regulation of mucus secretion|exocytic vesicle|protein localization to plasma membrane SYTL3 124.219447607937 151.034993349673 97.4039018662009 0.644909498825172 -0.632831375835082 0.0218119461869735 0.600929980812952 0.966298 0.682009 0.495681 0.610594 GeneID:94120,Genbank:XM_017011498.2,HGNC:HGNC:15587 synaptotagmin like 3 GO:0005509,GO:0005544,GO:0005886,GO:0006886,GO:0006906,GO:0017137,GO:0017158,GO:0019897,GO:0019905,GO:0030276,GO:0042043,GO:0048791,GO:0070382,GO:0098793 calcium ion binding|calcium-dependent phospholipid binding|plasma membrane|intracellular protein transport|vesicle fusion|Rab GTPase binding|regulation of calcium ion-dependent exocytosis|extrinsic component of plasma membrane|syntaxin binding|clathrin binding|neurexin family protein binding|calcium ion-regulated exocytosis of neurotransmitter|exocytic vesicle|presynapse SYTL4 308.392023272629 307.586250635571 309.197795909688 1.00523932806095 0.00753902011213699 0.982701070289313 1 1.3503 1.54168 1.50909 1.44232 GeneID:94121,Genbank:XM_024452481.1,HGNC:HGNC:15588,MIM:300723 synaptotagmin like 4 GO:0002576,GO:0005509,GO:0005543,GO:0005544,GO:0005654,GO:0005768,GO:0005815,GO:0005829,GO:0005886,GO:0006886,GO:0006906,GO:0017137,GO:0017158,GO:0019898,GO:0019905,GO:0030276,GO:0030658,GO:0031092,GO:0042043,GO:0045921,GO:0046676,GO:0048791,GO:0050714,GO:0070382,GO:0071985,GO:0098793 platelet degranulation|calcium ion binding|phospholipid binding|calcium-dependent phospholipid binding|nucleoplasm|endosome|microtubule organizing center|cytosol|plasma membrane|intracellular protein transport|vesicle fusion|Rab GTPase binding|regulation of calcium ion-dependent exocytosis|extrinsic component of membrane|syntaxin binding|clathrin binding|transport vesicle membrane|platelet alpha granule membrane|neurexin family protein binding|positive regulation of exocytosis|negative regulation of insulin secretion|calcium ion-regulated exocytosis of neurotransmitter|positive regulation of protein secretion|exocytic vesicle|multivesicular body sorting pathway|presynapse SYTL5 554.345832094733 549.810708367181 558.880955822284 1.01649703673841 0.0236060094875785 0.929493774736221 1 2.95805 2.58181 3.58093 2.28477 GeneID:94122,Genbank:XM_017029972.1,HGNC:HGNC:15589 synaptotagmin like 5 GO:0005509,GO:0005544,GO:0005886,GO:0006886,GO:0006906,GO:0017137,GO:0017158,GO:0019905,GO:0030276,GO:0048791,GO:0070382,GO:0098793 calcium ion binding|calcium-dependent phospholipid binding|plasma membrane|intracellular protein transport|vesicle fusion|Rab GTPase binding|regulation of calcium ion-dependent exocytosis|syntaxin binding|clathrin binding|calcium ion-regulated exocytosis of neurotransmitter|exocytic vesicle|presynapse SYVN1 1043.46084022749 1042.09400860918 1044.82767184581 1.0026232405273 0.00377958088946892 0.992958450031119 1 10.8049 10.5242 10.5173 10.85 GeneID:84447,Genbank:NM_032431.2,HGNC:HGNC:20738,MIM:608046 synoviolin 1 GO:0000836,GO:0000839,GO:0005654,GO:0005783,GO:0005789,GO:0005790,GO:0016020,GO:0016567,GO:0018279,GO:0030176,GO:0030433,GO:0030968,GO:0030970,GO:0036498,GO:0036503,GO:0036513,GO:0042787,GO:0044322,GO:0046872,GO:0050821,GO:0051082,GO:0051087,GO:0051117,GO:0061630,GO:0070936,GO:1902236,GO:1904264,GO:1904380,GO:1990381 Hrd1p ubiquitin ligase complex|Hrd1p ubiquitin ligase ERAD-L complex|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|smooth endoplasmic reticulum|membrane|protein ubiquitination|protein N-linked glycosylation via asparagine|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|IRE1-mediated unfolded protein response|ERAD pathway|Derlin-1 retrotranslocation complex|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|endoplasmic reticulum quality control compartment|metal ion binding|protein stabilization|unfolded protein binding|chaperone binding|ATPase binding|ubiquitin protein ligase activity|protein K48-linked ubiquitination|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|ubiquitin protein ligase activity involved in ERAD pathway|endoplasmic reticulum mannose trimming|ubiquitin-specific protease binding hsa04120,hsa04141 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum SZRD1 7050.35646875226 7039.87607652707 7060.83686097746 1.00297743656601 0.0042891507950776 0.993292501129145 1 71.2461 76.5489 74.1073 76.0924 GeneID:26099,Genbank:NM_001114600.2,HGNC:HGNC:30232 SUZ RNA binding domain containing 1 SZT2 1028.87410525988 995.904869313053 1061.84334120671 1.06620960889482 0.092491089116004 0.608415432718439 1 2.09832 2.64673 2.7515 2.43688 GeneID:23334,Genbank:NM_015284.3,HGNC:HGNC:29040,MIM:615463 SZT2, KICSTOR complex subunit GO:0005765,GO:0005777,GO:0007417,GO:0009791,GO:0021540,GO:0034198,GO:0042149,GO:0043473,GO:0061462,GO:0070062,GO:0140007,GO:1901668,GO:1904262 lysosomal membrane|peroxisome|central nervous system development|post-embryonic development|corpus callosum morphogenesis|cellular response to amino acid starvation|cellular response to glucose starvation|pigmentation|protein localization to lysosome|extracellular exosome|KICSTOR complex|regulation of superoxide dismutase activity|negative regulation of TORC1 signaling TAB1 655.435661449087 624.627936732387 686.243386165788 1.09864344165541 0.135723243957693 0.416530859055929 1 6.5844 6.4912 7.45784 6.86722 GeneID:10454,Genbank:NM_153497.2,HGNC:HGNC:18157,MIM:602615 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 GO:0000185,GO:0000187,GO:0001701,GO:0002223,GO:0002755,GO:0003007,GO:0003279,GO:0004722,GO:0005829,GO:0007179,GO:0007249,GO:0007254,GO:0008047,GO:0010008,GO:0016579,GO:0016607,GO:0019209,GO:0030324,GO:0032403,GO:0035904,GO:0038095,GO:0043234,GO:0048273,GO:0051092,GO:0060976,GO:0070423,GO:0070498 activation of MAPKKK activity|activation of MAPK activity|in utero embryonic development|stimulatory C-type lectin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|heart morphogenesis|cardiac septum development|protein serine/threonine phosphatase activity|cytosol|transforming growth factor beta receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|JNK cascade|enzyme activator activity|endosome membrane|protein deubiquitination|nuclear speck|kinase activator activity|lung development|protein complex binding|aorta development|Fc-epsilon receptor signaling pathway|protein complex|mitogen-activated protein kinase p38 binding|positive regulation of NF-kappaB transcription factor activity|coronary vasculature development|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway hsa04010,hsa04064,hsa04380,hsa04620,hsa04621,hsa04668,hsa05140,hsa05145,hsa05168,hsa05169,hsa05170 MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|TNF signaling pathway|Leishmaniasis|Toxoplasmosis|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection TAB2 1853.13176507495 1859.09237324161 1847.17115690829 0.993587614846414 -0.00928090453249165 0.984145633018983 1 11.5991 10.5278 13.0397 9.15446 GeneID:23118,Genbank:NM_001292035.2,HGNC:HGNC:17075,MIM:605101 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 GO:0000187,GO:0002223,GO:0002755,GO:0005654,GO:0005829,GO:0005886,GO:0007249,GO:0007254,GO:0007507,GO:0010008,GO:0010507,GO:0038095,GO:0043123,GO:0045860,GO:0046872,GO:0050852,GO:0051092,GO:0070423,GO:0070498,GO:0070530 activation of MAPK activity|stimulatory C-type lectin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|nucleoplasm|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|JNK cascade|heart development|endosome membrane|negative regulation of autophagy|Fc-epsilon receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of protein kinase activity|metal ion binding|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding hsa04010,hsa04064,hsa04380,hsa04620,hsa04621,hsa04657,hsa04668,hsa05140,hsa05145,hsa05162,hsa05168,hsa05169,hsa05170 MAPK signaling pathway|NF-kappa B signaling pathway|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Leishmaniasis|Toxoplasmosis|Measles|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection TAB3 275.28716673878 300.455693669419 250.11863980814 0.832464303649831 -0.264539684627183 0.429174214408921 1 1.24811 1.10612 1.26236 0.794393 GeneID:257397,Genbank:NM_152787.4,HGNC:HGNC:30681,MIM:300480 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 GO:0000187,GO:0002223,GO:0002755,GO:0005829,GO:0005886,GO:0007249,GO:0007254,GO:0010008,GO:0010507,GO:0038095,GO:0046872,GO:0051092,GO:0070062,GO:0070423,GO:0070498 activation of MAPK activity|stimulatory C-type lectin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|cytosol|plasma membrane|I-kappaB kinase/NF-kappaB signaling|JNK cascade|endosome membrane|negative regulation of autophagy|Fc-epsilon receptor signaling pathway|metal ion binding|positive regulation of NF-kappaB transcription factor activity|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway hsa04064,hsa04621,hsa04657,hsa04668 NF-kappa B signaling pathway|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway TAC1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0455021 0 0 0 GeneID:6863,Genbank:NM_003182.2,HGNC:HGNC:11517,MIM:162320 tachykinin precursor 1 GO:0005576,GO:0007217,GO:0007218,GO:0007268 extracellular region|tachykinin receptor signaling pathway|neuropeptide signaling pathway|chemical synaptic transmission hsa04080 Neuroactive ligand-receptor interaction TAC4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:255061,Genbank:NM_001077505.1,HGNC:HGNC:16641,MIM:607833 tachykinin 4 GO:0003085,GO:0005102,GO:0005615,GO:0005623,GO:0006954,GO:0007204,GO:0007217,GO:0007267,GO:0008217,GO:0031835,GO:0031837,GO:0048018,GO:0050965,GO:0051930,GO:1902093,GO:1904057,GO:1904058 negative regulation of systemic arterial blood pressure|receptor binding|extracellular space|cell|inflammatory response|positive regulation of cytosolic calcium ion concentration|tachykinin receptor signaling pathway|cell-cell signaling|regulation of blood pressure|substance P receptor binding|substance K receptor binding|receptor ligand activity|detection of temperature stimulus involved in sensory perception of pain|regulation of sensory perception of pain|positive regulation of flagellated sperm motility|negative regulation of sensory perception of pain|positive regulation of sensory perception of pain hsa04080 Neuroactive ligand-receptor interaction TACC1 3594.98465972408 3621.59773902721 3568.37158042095 0.985303127944694 -0.0213604577245821 0.929677048991202 1 11.1291 11.1204 13.2576 8.97955 GeneID:6867,Genbank:NM_001330521.1,HGNC:HGNC:11522,MIM:605301 transforming acidic coiled-coil containing protein 1 TACC2 314.014578977874 295.094334213212 332.934823742537 1.12823184026971 0.174063557487975 0.378336807266078 1 0.618844 0.597594 0.667933 0.701799 GeneID:10579,Genbank:NM_001291877.1,HGNC:HGNC:11523,MIM:605302 transforming acidic coiled-coil containing protein 2 GO:0000226,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0005886,GO:0008283,GO:0015630,GO:0021987,GO:0035257 microtubule cytoskeleton organization|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|plasma membrane|cell proliferation|microtubule cytoskeleton|cerebral cortex development|nuclear hormone receptor binding TACC3 6464.7101293051 6102.11314825499 6827.30711035521 1.11884308672769 0.162007718286263 0.220537148721573 1 48.8143 48.8426 55.6403 56.2737 GeneID:10460,Genbank:NM_006342.2,HGNC:HGNC:11524,MIM:605303 transforming acidic coiled-coil containing protein 3 hsa03013 RNA transport TACO1 921.506504083755 910.632445372473 932.380562795036 1.02388243196592 0.0340500663560391 0.840297606027516 1 21.7328 22.9685 22.2106 23.9607 GeneID:51204,Genbank:NM_016360.3,HGNC:HGNC:24316,MIM:612958 translational activator of cytochrome c oxidase I GO:0005634,GO:0005739,GO:0006417 nucleus|mitochondrion|regulation of translation TACR1 49.0248255329002 37.4561319568604 60.59351910894 1.61771960806652 0.693961573709349 0.156641905885851 1 0.274374 0.268846 0.630087 0.316249 GeneID:6869,Genbank:NM_001058.3,HGNC:HGNC:11526,MIM:162323 tachykinin receptor 1 hsa04020,hsa04080,hsa05162 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Measles TACR2 2.18313398119387 0.490071401957362 3.87619656043037 7.90945267352617 2.98357786505084 0.285120129932373 1 0 0 0.0383162 0.0714953 GeneID:6865,Genbank:NM_001057.2,HGNC:HGNC:11527,MIM:162321 tachykinin receptor 2 GO:0004995,GO:0005886,GO:0005887,GO:0006936,GO:0007186,GO:0007217,GO:0007268,GO:0007588,GO:0014057,GO:0014827,GO:0016497,GO:0033685,GO:0035106,GO:0036126,GO:0043117,GO:0045987,GO:0051602,GO:0061827,GO:0070459,GO:0070474,GO:0097225,GO:1902093 tachykinin receptor activity|plasma membrane|integral component of plasma membrane|muscle contraction|G-protein coupled receptor signaling pathway|tachykinin receptor signaling pathway|chemical synaptic transmission|excretion|positive regulation of acetylcholine secretion, neurotransmission|intestine smooth muscle contraction|substance K receptor activity|negative regulation of luteinizing hormone secretion|operant conditioning|sperm flagellum|positive regulation of vascular permeability|positive regulation of smooth muscle contraction|response to electrical stimulus|sperm head|prolactin secretion|positive regulation of uterine smooth muscle contraction|sperm midpiece|positive regulation of flagellated sperm motility hsa04020,hsa04080 Calcium signaling pathway|Neuroactive ligand-receptor interaction TACSTD2 3.34267990332637 4.74682654041085 1.93853326624189 0.408385107342494 -1.29199783874727 0.5171803438141 1 0.199259 0.0489772 0.0528955 0.0491731 GeneID:4070,Genbank:NM_002353.2,HGNC:HGNC:11530,MIM:137290 tumor associated calcium signal transducer 2 GO:0004872,GO:0005615,GO:0005634,GO:0005829,GO:0005887,GO:0007166,GO:0007601,GO:0008283,GO:0009925,GO:0010633,GO:0016020,GO:0016328,GO:0050678,GO:0051497,GO:0060675,GO:0070062,GO:0090191,GO:0098609,GO:1900025,GO:1900028,GO:2000146,GO:2000738 receptor activity|extracellular space|nucleus|cytosol|integral component of plasma membrane|cell surface receptor signaling pathway|visual perception|cell proliferation|basal plasma membrane|negative regulation of epithelial cell migration|membrane|lateral plasma membrane|regulation of epithelial cell proliferation|negative regulation of stress fiber assembly|ureteric bud morphogenesis|extracellular exosome|negative regulation of branching involved in ureteric bud morphogenesis|cell-cell adhesion|negative regulation of substrate adhesion-dependent cell spreading|negative regulation of ruffle assembly|negative regulation of cell motility|positive regulation of stem cell differentiation TADA1 337.702625239367 357.466655429889 317.938595048844 0.889421685126103 -0.169060515200748 0.388947136823422 1 6.93389 6.80368 6.61342 5.54163 GeneID:117143,Genbank:NM_053053.3,HGNC:HGNC:30631,MIM:612763 transcriptional adaptor 1 GO:0000124,GO:0003713,GO:0005634,GO:0005654,GO:0005829,GO:0005925,GO:0006351,GO:0006357,GO:0030914,GO:0043966 SAGA complex|transcription coactivator activity|nucleus|nucleoplasm|cytosol|focal adhesion|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|STAGA complex|histone H3 acetylation TADA2A 364.921068277994 380.93224779405 348.909888761938 0.915936864842629 -0.126679937523212 0.504022061562728 1 2.19837 2.37583 2.00552 2.1432 GeneID:6871,Genbank:XM_017024984.1,HGNC:HGNC:11531,MIM:602276 transcriptional adaptor 2A GO:0000125,GO:0003677,GO:0003682,GO:0003700,GO:0003712,GO:0003713,GO:0005634,GO:0005694,GO:0006338,GO:0006357,GO:0006366,GO:0035066,GO:0043966 PCAF complex|DNA binding|chromatin binding|DNA binding transcription factor activity|transcription cofactor activity|transcription coactivator activity|nucleus|chromosome|chromatin remodeling|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|positive regulation of histone acetylation|histone H3 acetylation TADA2B 658.466368665568 639.407531031116 677.52520630002 1.05961405429091 0.0835388842687632 0.642458105307336 1 4.86675 5.74156 5.95212 5.44429 GeneID:93624,Genbank:NM_152293.2,HGNC:HGNC:30781,MIM:608790 transcriptional adaptor 2B GO:0003677,GO:0003713,GO:0005634,GO:0006351,GO:0006357,GO:0008270,GO:0035065 DNA binding|transcription coactivator activity|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|zinc ion binding|regulation of histone acetylation TADA3 4909.75382333258 4629.4006261579 5190.10702050727 1.12111857227935 0.164938869216512 0.221069106220728 1 43.428 45.9232 49.6674 52.6213 GeneID:10474,Genbank:NM_001278270.1,HGNC:HGNC:19422,MIM:602945 transcriptional adaptor 3 GO:0000124,GO:0000278,GO:0001932,GO:0003700,GO:0003713,GO:0005622,GO:0005634,GO:0005654,GO:0005671,GO:0006351,GO:0006357,GO:0010628,GO:0016579,GO:0016922,GO:0019904,GO:0030374,GO:0030520,GO:0030914,GO:0031063,GO:0031647,GO:0033276,GO:0036459,GO:0043966,GO:0043967,GO:0045893,GO:0072686,GO:0090043 SAGA complex|mitotic cell cycle|regulation of protein phosphorylation|DNA binding transcription factor activity|transcription coactivator activity|intracellular|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|protein deubiquitination|ligand-dependent nuclear receptor binding|protein domain specific binding|ligand-dependent nuclear receptor transcription coactivator activity|intracellular estrogen receptor signaling pathway|STAGA complex|regulation of histone deacetylation|regulation of protein stability|transcription factor TFTC complex|thiol-dependent ubiquitinyl hydrolase activity|histone H3 acetylation|histone H4 acetylation|positive regulation of transcription, DNA-templated|mitotic spindle|regulation of tubulin deacetylation hsa05165 Human papillomavirus infection TAF1 631.477557893725 652.733477431625 610.221638355825 0.93487106063094 -0.0971606956794679 0.638304005341604 1 2.27641 2.18668 2.45318 1.76937 GeneID:6872,Genbank:XM_005262297.4,HGNC:HGNC:11535,MIM:313650 TATA-box binding protein associated factor 1 GO:0000209,GO:0000790,GO:0000979,GO:0001129,GO:0002039,GO:0003677,GO:0003713,GO:0004402,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005669,GO:0006468,GO:0006974,GO:0007049,GO:0008134,GO:0010629,GO:0010767,GO:0016301,GO:0016573,GO:0017025,GO:0018105,GO:0018107,GO:0030901,GO:0032092,GO:0032436,GO:0034644,GO:0036369,GO:0042787,GO:0043565,GO:0045120,GO:0045943,GO:0045944,GO:0046777,GO:0046982,GO:0050821,GO:0061631,GO:0070577,GO:0071318,GO:0071339,GO:1903026,GO:1905524,GO:2000059,GO:2000825 protein polyubiquitination|nuclear chromatin|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly|p53 binding|DNA binding|transcription coactivator activity|histone acetyltransferase activity|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|transcription factor TFIID complex|protein phosphorylation|cellular response to DNA damage stimulus|cell cycle|transcription factor binding|negative regulation of gene expression|regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|kinase activity|histone acetylation|TBP-class protein binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|midbrain development|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to UV|transcription factor catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|sequence-specific DNA binding|pronucleus|positive regulation of transcription from RNA polymerase I promoter|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|protein heterodimerization activity|protein stabilization|ubiquitin conjugating enzyme activity|lysine-acetylated histone binding|cellular response to ATP|MLL1 complex|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|negative regulation of protein autoubiquitination|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of androgen receptor activity hsa03022 Basal transcription factors TAF10 1198.44659488008 1140.33861171896 1256.55457804119 1.1019135589446 0.140011054241855 0.477198843391161 1 72.0625 80.7187 81.9184 90.1761 GeneID:6881,Genbank:NM_006284.3,HGNC:HGNC:11543,MIM:600475 TATA-box binding protein associated factor 10 hsa03022,hsa05168 Basal transcription factors|Herpes simplex infection TAF11 979.645148172654 975.993221275579 983.297075069728 1.00748350873237 0.0107562238006379 0.956992802943366 1 14.5163 15.6159 15.8269 15.7186 GeneID:6882,Genbank:NM_001270488.1,HGNC:HGNC:11544,MIM:600772 TATA-box binding protein associated factor 11 hsa03022 Basal transcription factors TAF12 603.619840963322 617.478779456874 589.760902469771 0.955111207203779 -0.0662593735286775 0.689364573204298 1 9.97391 10.1637 8.56275 9.38236 GeneID:6883,Genbank:XM_017002186.1,HGNC:HGNC:11545,MIM:600773 TATA-box binding protein associated factor 12 hsa03022 Basal transcription factors TAF13 453.691674262758 459.139724351671 448.243624173846 0.976268443787542 -0.0346501957971783 0.879218037098916 1 22.8062 18.6179 18.6984 19.9239 GeneID:6884,Genbank:NM_005645.3,HGNC:HGNC:11546,MIM:600774 TATA-box binding protein associated factor 13 GO:0003677,GO:0003700,GO:0003712,GO:0005634,GO:0005654,GO:0005669,GO:0005730,GO:0006352,GO:0006357,GO:0006366,GO:0006367,GO:0006368,GO:0008022,GO:0042795,GO:0046982,GO:1901796 DNA binding|DNA binding transcription factor activity|transcription cofactor activity|nucleus|nucleoplasm|transcription factor TFIID complex|nucleolus|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|protein C-terminus binding|snRNA transcription from RNA polymerase II promoter|protein heterodimerization activity|regulation of signal transduction by p53 class mediator hsa03022,hsa05168 Basal transcription factors|Herpes simplex infection TAF15 5630.88965962151 5778.70322358186 5483.07609566117 0.948841960474058 -0.0757602835391995 0.587056766188611 1 71.4102 65.1904 68.09 64.009 GeneID:8148,Genbank:NM_139215.2,HGNC:HGNC:11547,MIM:601574 TATA-box binding protein associated factor 15 hsa03022,hsa05202 Basal transcription factors|Transcriptional misregulation in cancer TAF1A 90.3092169526634 114.703083020782 65.9153508845445 0.57466067300564 -0.799217773399947 0.0113633941533263 0.432003248403162 0.98518 0.670252 0.524751 0.427163 GeneID:9015,Genbank:NM_139352.2,HGNC:HGNC:11532,MIM:604903 TATA-box binding protein associated factor, RNA polymerase I subunit A GO:0000120,GO:0003677,GO:0005654,GO:0006355,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0015630,GO:0045815 RNA polymerase I transcription factor complex|DNA binding|nucleoplasm|regulation of transcription, DNA-templated|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|microtubule cytoskeleton|positive regulation of gene expression, epigenetic TAF1B 218.466116511009 252.285634454398 184.64659856762 0.731895016404494 -0.450291372846368 0.0443893449012526 0.785206567052859 2.74777 2.39427 1.96204 1.58673 GeneID:9014,Genbank:NM_001318976.1,HGNC:HGNC:11533,MIM:604904 TATA-box binding protein associated factor, RNA polymerase I subunit B GO:0001164,GO:0001187,GO:0001189,GO:0003700,GO:0005634,GO:0005654,GO:0005668,GO:0006351,GO:0006361,GO:0006362,GO:0006363,GO:0017025,GO:0045815,GO:0046872,GO:0070062,GO:0070860 RNA polymerase I CORE element sequence-specific DNA binding|transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting|RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript|DNA binding transcription factor activity|nucleus|nucleoplasm|RNA polymerase transcription factor SL1 complex|transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|TBP-class protein binding|positive regulation of gene expression, epigenetic|metal ion binding|extracellular exosome|RNA polymerase I core factor complex TAF1C 475.137375161189 463.715080104412 486.559670217966 1.04926428122288 0.0693780994489458 0.726590054217291 1 3.63444 4.31475 4.0879 4.27978 GeneID:9013,Genbank:NM_001243160.1,HGNC:HGNC:11534,MIM:604905 TATA-box binding protein associated factor, RNA polymerase I subunit C TAF1D 188.856346817787 193.055655403313 184.657038232261 0.956496393988011 -0.0641685652970734 0.797356696742082 1 3.67158 3.51653 4.04738 3.22959 GeneID:79101,Genbank:NM_024116.3,HGNC:HGNC:28759,MIM:612823 TATA-box binding protein associated factor, RNA polymerase I subunit D GO:0003677,GO:0005654,GO:0005668,GO:0005815,GO:0006355,GO:0006361,GO:0006362,GO:0006363,GO:0045815 DNA binding|nucleoplasm|RNA polymerase transcription factor SL1 complex|microtubule organizing center|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|positive regulation of gene expression, epigenetic TAF1L 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00447839 GeneID:138474,Genbank:NM_153809.2,HGNC:HGNC:18056,MIM:607798 TATA-box binding protein associated factor 1 like GO:0001129,GO:0004402,GO:0004674,GO:0005654,GO:0005669,GO:0006357,GO:0006366,GO:0006367,GO:0006368,GO:0007140,GO:0017025,GO:0043565,GO:0045893,GO:0045944,GO:0070577,GO:1901796 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly|histone acetyltransferase activity|protein serine/threonine kinase activity|nucleoplasm|transcription factor TFIID complex|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|male meiotic nuclear division|TBP-class protein binding|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|lysine-acetylated histone binding|regulation of signal transduction by p53 class mediator hsa03022 Basal transcription factors TAF2 541.262172933388 558.583967327728 523.940378539047 0.937979622017408 -0.0923715149332581 0.623302981732726 1 2.81703 2.64749 2.96514 2.13136 GeneID:6873,Genbank:XM_017013791.2,HGNC:HGNC:11536,MIM:604912 TATA-box binding protein associated factor 2 GO:0000086,GO:0001129,GO:0003682,GO:0005654,GO:0005669,GO:0006366,GO:0006367,GO:0006368,GO:0014070,GO:0033276,GO:0043565,GO:0044212,GO:0045944,GO:1901796 G2/M transition of mitotic cell cycle|RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly|chromatin binding|nucleoplasm|transcription factor TFIID complex|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|response to organic cyclic compound|transcription factor TFTC complex|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|regulation of signal transduction by p53 class mediator hsa03022 Basal transcription factors TAF3 345.810215021298 340.757218489509 350.863211553087 1.0296574584931 0.0421644683547194 0.857781651300051 1 2.06971 2.55726 2.38351 2.4077 GeneID:83860,Genbank:NM_031923.3,HGNC:HGNC:17303,MIM:606576 TATA-box binding protein associated factor 3 GO:0000122,GO:0002039,GO:0005634,GO:0005654,GO:0005669,GO:0006366,GO:0006367,GO:0006368,GO:0031965,GO:0043433,GO:0046872,GO:0051457,GO:1901796 negative regulation of transcription from RNA polymerase II promoter|p53 binding|nucleus|nucleoplasm|transcription factor TFIID complex|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|nuclear membrane|negative regulation of DNA binding transcription factor activity|metal ion binding|maintenance of protein location in nucleus|regulation of signal transduction by p53 class mediator hsa03022,hsa05168 Basal transcription factors|Herpes simplex infection TAF4 414.522726022022 436.491595658009 392.553856386035 0.899338865377837 -0.153063278051775 0.409434214945682 1 4.53822 4.1123 4.082 3.74243 GeneID:6874,Genbank:NM_003185.3,HGNC:HGNC:11537,MIM:601796 TATA-box binding protein associated factor 4 hsa03022,hsa05016,hsa05168 Basal transcription factors|Huntington disease|Herpes simplex infection TAF4B 48.717951745654 63.5063514997546 33.9295519915534 0.534270213770421 -0.904358507529336 0.027432571616409 0.664689965216953 0.349479 0.391302 0.275747 0.173462 GeneID:6875,Genbank:XM_024451239.1,HGNC:HGNC:11538,MIM:601689 TATA-box binding protein associated factor 4b GO:0001650,GO:0003677,GO:0003700,GO:0003713,GO:0005654,GO:0005669,GO:0005737,GO:0006366,GO:0006367,GO:0006368,GO:0007283,GO:0045944,GO:0046982,GO:0048477,GO:0051059,GO:0051123,GO:1901796 fibrillar center|DNA binding|DNA binding transcription factor activity|transcription coactivator activity|nucleoplasm|transcription factor TFIID complex|cytoplasm|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|spermatogenesis|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|oogenesis|NF-kappaB binding|RNA polymerase II transcriptional preinitiation complex assembly|regulation of signal transduction by p53 class mediator hsa03022,hsa05016,hsa05168 Basal transcription factors|Huntington disease|Herpes simplex infection TAF5 215.605606198219 232.490673277364 198.720539119075 0.854746284303626 -0.226431848803286 0.456528788807362 1 2.60266 1.97407 2.37297 1.55624 GeneID:6877,Genbank:NM_006951.4,HGNC:HGNC:11539,MIM:601787 TATA-box binding protein associated factor 5 GO:0000790,GO:0003700,GO:0005634,GO:0005654,GO:0005669,GO:0006325,GO:0006352,GO:0006366,GO:0006367,GO:0006368,GO:0015629,GO:0016032,GO:0016573,GO:0033276,GO:0042795,GO:0042802,GO:0044212,GO:0046983,GO:1901796 nuclear chromatin|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor TFIID complex|chromatin organization|DNA-templated transcription, initiation|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|actin cytoskeleton|viral process|histone acetylation|transcription factor TFTC complex|snRNA transcription from RNA polymerase II promoter|identical protein binding|transcription regulatory region DNA binding|protein dimerization activity|regulation of signal transduction by p53 class mediator hsa03022,hsa05168 Basal transcription factors|Herpes simplex infection TAF5L 887.18842771435 866.641689055896 907.735166372804 1.04741691732102 0.0668358117311337 0.672477503538286 1 3.8231 4.18328 4.36382 3.92703 GeneID:27097,Genbank:NM_014409.3,HGNC:HGNC:17304 TATA-box binding protein associated factor 5 like GO:0003700,GO:0003713,GO:0005634,GO:0006366,GO:0016607,GO:0030914,GO:0033276,GO:0036464,GO:0043966 DNA binding transcription factor activity|transcription coactivator activity|nucleus|transcription from RNA polymerase II promoter|nuclear speck|STAGA complex|transcription factor TFTC complex|cytoplasmic ribonucleoprotein granule|histone H3 acetylation hsa03022,hsa05168 Basal transcription factors|Herpes simplex infection TAF6 2336.47433921644 2334.65947889068 2338.28919954219 1.00155471094792 0.00224123199172352 0.991159890160806 1 19.3014 21.2698 21.4364 21.0158 GeneID:6878,Genbank:XM_024446896.1,HGNC:HGNC:11540,MIM:602955 TATA-box binding protein associated factor 6 hsa03022,hsa05168 Basal transcription factors|Herpes simplex infection TAF6L 465.740857466667 482.750412540741 448.731302392594 0.929530645102709 -0.10542566566632 0.539046364688482 1 9.21146 9.19191 8.71743 9.44915 GeneID:10629,Genbank:NM_006473.3,HGNC:HGNC:17305,MIM:602946 TATA-box binding protein associated factor 6 like GO:0000118,GO:0003677,GO:0003713,GO:0005634,GO:0005654,GO:0006338,GO:0006352,GO:0006357,GO:0030914,GO:0043966,GO:0046982,GO:0051090,GO:0070062 histone deacetylase complex|DNA binding|transcription coactivator activity|nucleus|nucleoplasm|chromatin remodeling|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|STAGA complex|histone H3 acetylation|protein heterodimerization activity|regulation of DNA binding transcription factor activity|extracellular exosome hsa03022,hsa05168 Basal transcription factors|Herpes simplex infection TAF7 2735.2290727825 2695.99461125813 2774.46353430688 1.02910574179973 0.0413912284246086 0.751708308167457 1 44.8226 44.2931 46.5507 45.1285 GeneID:6879,Genbank:NM_005642.2,HGNC:HGNC:11541,MIM:600573 TATA-box binding protein associated factor 7 GO:0000122,GO:0000296,GO:0003713,GO:0005654,GO:0005667,GO:0005669,GO:0005794,GO:0006352,GO:0006366,GO:0006367,GO:0006368,GO:0006469,GO:0008134,GO:0030520,GO:0033276,GO:0035035,GO:0035067,GO:0042809,GO:0044212,GO:0045892,GO:0045944,GO:0046966,GO:0046982,GO:0051123,GO:0060260,GO:0071339,GO:1901796 negative regulation of transcription from RNA polymerase II promoter|spermine transport|transcription coactivator activity|nucleoplasm|transcription factor complex|transcription factor TFIID complex|Golgi apparatus|DNA-templated transcription, initiation|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|negative regulation of protein kinase activity|transcription factor binding|intracellular estrogen receptor signaling pathway|transcription factor TFTC complex|histone acetyltransferase binding|negative regulation of histone acetylation|vitamin D receptor binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|thyroid hormone receptor binding|protein heterodimerization activity|RNA polymerase II transcriptional preinitiation complex assembly|regulation of transcription initiation from RNA polymerase II promoter|MLL1 complex|regulation of signal transduction by p53 class mediator hsa03022 Basal transcription factors TAF7L 4.3973636689536 7.34126237425249 1.45346496365472 0.197985699128852 -2.33653186933502 0.147963618061901 1 0.106013 0.0433086 0.0145444 0.0270211 GeneID:54457,Genbank:NM_024885.3,HGNC:HGNC:11548,MIM:300314 TATA-box binding protein associated factor 7 like GO:0003713,GO:0005669,GO:0005737,GO:0006357,GO:0007275,GO:0007283,GO:0008134,GO:0030154,GO:0035035,GO:0044212,GO:0051123 transcription coactivator activity|transcription factor TFIID complex|cytoplasm|regulation of transcription from RNA polymerase II promoter|multicellular organism development|spermatogenesis|transcription factor binding|cell differentiation|histone acetyltransferase binding|transcription regulatory region DNA binding|RNA polymerase II transcriptional preinitiation complex assembly hsa03022 Basal transcription factors TAF8 661.143902017801 714.078646570558 608.209157465045 0.851739735372339 -0.231515438907573 0.156926318844632 1 3.66499 3.78802 3.28776 3.0527 GeneID:129685,Genbank:NM_138572.2,HGNC:HGNC:17300,MIM:609514 TATA-box binding protein associated factor 8 GO:0001833,GO:0005634,GO:0005654,GO:0005669,GO:0030154,GO:0042795,GO:0045598,GO:0045893,GO:0046982,GO:0048471,GO:0051457 inner cell mass cell proliferation|nucleus|nucleoplasm|transcription factor TFIID complex|cell differentiation|snRNA transcription from RNA polymerase II promoter|regulation of fat cell differentiation|positive regulation of transcription, DNA-templated|protein heterodimerization activity|perinuclear region of cytoplasm|maintenance of protein location in nucleus hsa03022 Basal transcription factors TAF9 775.09521070964 762.641707637312 787.548713781968 1.03265885657082 0.0463637322096025 0.752113634613738 1 28.8399 23.6813 28.2305 25.798 GeneID:6880,Genbank:NM_001015892.1,HGNC:HGNC:11542,MIM:600822 TATA-box binding protein associated factor 9 hsa03022 Basal transcription factors TAF9B 401.104685894401 413.01619463874 389.193177150061 0.942319410720645 -0.0857119329740687 0.66906624664393 1 7.15799 6.45568 7.15227 5.40472 GeneID:51616,Genbank:NM_015975.4,HGNC:HGNC:17306,MIM:300754 TATA-box binding protein associated factor 9b GO:0000122,GO:0000124,GO:0003714,GO:0005654,GO:0005669,GO:0006366,GO:0006367,GO:0006368,GO:0008134,GO:0016579,GO:0030307,GO:0033276,GO:0036459,GO:0043066,GO:0043966,GO:0044212,GO:0045944,GO:0046982,GO:0050821,GO:0051123,GO:1901796,GO:1902166 negative regulation of transcription from RNA polymerase II promoter|SAGA complex|transcription corepressor activity|nucleoplasm|transcription factor TFIID complex|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription factor binding|protein deubiquitination|positive regulation of cell growth|transcription factor TFTC complex|thiol-dependent ubiquitinyl hydrolase activity|negative regulation of apoptotic process|histone H3 acetylation|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|protein stabilization|RNA polymerase II transcriptional preinitiation complex assembly|regulation of signal transduction by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator hsa03022,hsa05168 Basal transcription factors|Herpes simplex infection TAGAP 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:117289,Genbank:NM_152133.2,HGNC:HGNC:15669,MIM:609667 T cell activation RhoGTPase activating protein GO:0005085,GO:0005096,GO:0005829,GO:0007165,GO:0051056 guanyl-nucleotide exchange factor activity|GTPase activator activity|cytosol|signal transduction|regulation of small GTPase mediated signal transduction TAGLN 95.4316635166723 106.065111230036 84.7982158033082 0.799492074442801 -0.322844362893752 0.278118521541615 1 0.804853 0.90245 0.613976 0.752462 GeneID:6876,Genbank:NM_001001522.2,HGNC:HGNC:11553,MIM:600818 transgelin TAGLN2 16580.9977313553 17409.6958663369 15752.2995963736 0.904800389237811 -0.144328544923754 0.256134927925222 1 425.681 446.269 377.97 420.997 GeneID:8407,Genbank:NM_003564.2,HGNC:HGNC:11554,MIM:604634 transgelin 2 GO:0002576,GO:0005576,GO:0005829,GO:0030855,GO:0031982,GO:0045296,GO:0070062 platelet degranulation|extracellular region|cytosol|epithelial cell differentiation|vesicle|cadherin binding|extracellular exosome TAGLN3 1.21723886981142 0.980142803914724 1.45433493570811 1.48379902387637 0.569295696478757 1 1 0 0.027151 0.028358 0.0264346 GeneID:29114,Genbank:NM_013259.2,HGNC:HGNC:29868,MIM:607953 transgelin 3 GO:0000122,GO:0005634,GO:0007417,GO:0043209,GO:0051015 negative regulation of transcription from RNA polymerase II promoter|nucleus|central nervous system development|myelin sheath|actin filament binding TAL1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.00656043 0 0 GeneID:6886,Genbank:XM_017002189.1,HGNC:HGNC:11556,MIM:187040 TAL bHLH transcription factor 1, erythroid differentiation factor TAL2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0814906 0 0 0 GeneID:6887,Genbank:NM_005421.2,HGNC:HGNC:11557,MIM:186855 TAL bHLH transcription factor 2 TALDO1 4555.13544160775 4372.7818013259 4737.4890818896 1.08340395133668 0.115571257656362 0.399295797702804 1 141.299 151.265 155.218 166.521 GeneID:6888,Genbank:NM_006755.1,HGNC:HGNC:11559,MIM:602063 transaldolase 1 GO:0004801,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005975,GO:0005999,GO:0006002,GO:0006098,GO:0009052,GO:0035722,GO:0048029,GO:0070062 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity|nucleus|nucleoplasm|cytoplasm|cytosol|carbohydrate metabolic process|xylulose biosynthetic process|fructose 6-phosphate metabolic process|pentose-phosphate shunt|pentose-phosphate shunt, non-oxidative branch|interleukin-12-mediated signaling pathway|monosaccharide binding|extracellular exosome hsa00030 Pentose phosphate pathway TAMM41 275.520488746344 271.398419130735 279.642558361953 1.03037651898498 0.0431716216921861 0.841345277386159 1 0.98073 1.07816 1.17375 0.907965 GeneID:132001,Genbank:XM_017005725.2,HGNC:HGNC:25187,MIM:614948 TAM41 mitochondrial translocator assembly and maintenance homolog GO:0004605,GO:0016024,GO:0031314,GO:0032049 phosphatidate cytidylyltransferase activity|CDP-diacylglycerol biosynthetic process|extrinsic component of mitochondrial inner membrane|cardiolipin biosynthetic process TANC1 900.879349343523 813.540472855122 988.218225831925 1.21471304600713 0.280615543463063 0.0645186026759216 0.90091963811897 3.21378 2.70253 3.97061 3.23389 GeneID:85461,Genbank:XM_017005142.1,HGNC:HGNC:29364,MIM:611397 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 GO:0007520,GO:0008542,GO:0014069,GO:0030054,GO:0030425,GO:0043025,GO:0043679,GO:0045211,GO:0097062 myoblast fusion|visual learning|postsynaptic density|cell junction|dendrite|neuronal cell body|axon terminus|postsynaptic membrane|dendritic spine maintenance TANC2 1662.70354313518 1707.47227294147 1617.9348133289 0.947561397610092 -0.077708668587468 0.740123132703618 1 3.63294 3.51997 4.05898 2.74306 GeneID:26115,Genbank:XM_011524597.2,HGNC:HGNC:30212,MIM:615047 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 GO:0001701 in utero embryonic development TANGO2 528.937238655337 508.781014773419 549.093462537254 1.07923339628109 0.110006897490403 0.532449792790289 1 3.65166 3.54236 4.37193 4.06744 GeneID:128989,Genbank:NM_001283106.2,HGNC:HGNC:25439,MIM:616830 transport and golgi organization 2 homolog GO:0005794 Golgi apparatus TANGO6 545.646129840574 515.593988126137 575.69827155501 1.11657289420172 0.159077438953044 0.361854313667515 1 3.1652 3.43421 3.5924 3.98696 GeneID:79613,Genbank:NM_024562.1,HGNC:HGNC:25749 transport and golgi organization 6 homolog GO:0016021 integral component of membrane TANK 317.458252060096 337.355127640276 297.561376479916 0.88204195549447 -0.181080813770988 0.35740428495254 1 2.08333 2.72453 2.1466 2.21517 GeneID:10010,Genbank:NM_004180.2,HGNC:HGNC:11562,MIM:603893 TRAF family member associated NFKB activator GO:0005829,GO:0006508,GO:0006974,GO:0007165,GO:0007249,GO:0016032,GO:0031625,GO:0035666,GO:0035800,GO:0043124,GO:0043234,GO:0046872,GO:0071347,GO:0071356,GO:0071479,GO:1903003,GO:2000158 cytosol|proteolysis|cellular response to DNA damage stimulus|signal transduction|I-kappaB kinase/NF-kappaB signaling|viral process|ubiquitin protein ligase binding|TRIF-dependent toll-like receptor signaling pathway|deubiquitinase activator activity|negative regulation of I-kappaB kinase/NF-kappaB signaling|protein complex|metal ion binding|cellular response to interleukin-1|cellular response to tumor necrosis factor|cellular response to ionizing radiation|positive regulation of protein deubiquitination|positive regulation of ubiquitin-specific protease activity hsa04621,hsa04622 NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway TAOK1 906.593104658298 974.059310630509 839.126898686086 0.86147413153201 -0.215120619239006 0.639245520396041 1 3.47249 2.93885 3.72444 1.8377 GeneID:57551,Genbank:NM_020791.2,HGNC:HGNC:29259,MIM:610266 TAO kinase 1 GO:0000187,GO:0004672,GO:0004674,GO:0004709,GO:0005524,GO:0005737,GO:0005829,GO:0006281,GO:0006468,GO:0006974,GO:0007062,GO:0007095,GO:0007257,GO:0007346,GO:0007399,GO:0016301,GO:0016740,GO:0032874,GO:0032956,GO:0042981,GO:0043539,GO:0046330,GO:0046777,GO:0051493,GO:0070062,GO:0070507,GO:0097194 activation of MAPK activity|protein kinase activity|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|ATP binding|cytoplasm|cytosol|DNA repair|protein phosphorylation|cellular response to DNA damage stimulus|sister chromatid cohesion|mitotic G2 DNA damage checkpoint|activation of JUN kinase activity|regulation of mitotic cell cycle|nervous system development|kinase activity|transferase activity|positive regulation of stress-activated MAPK cascade|regulation of actin cytoskeleton organization|regulation of apoptotic process|protein serine/threonine kinase activator activity|positive regulation of JNK cascade|protein autophosphorylation|regulation of cytoskeleton organization|extracellular exosome|regulation of microtubule cytoskeleton organization|execution phase of apoptosis hsa04010 MAPK signaling pathway TAOK2 1756.06426826574 1676.80172237371 1835.32681415776 1.09454015323865 0.130324880800912 0.365754062497119 1 8.96799 8.82479 10.2349 9.47607 GeneID:9344,Genbank:NM_004783.3,HGNC:HGNC:16835,MIM:613199 TAO kinase 2 GO:0000186,GO:0000187,GO:0001558,GO:0004674,GO:0004709,GO:0005524,GO:0005622,GO:0005634,GO:0005730,GO:0005829,GO:0006612,GO:0006915,GO:0006950,GO:0006974,GO:0007095,GO:0007257,GO:0007346,GO:0007399,GO:0007409,GO:0008360,GO:0010976,GO:0015629,GO:0016021,GO:0016477,GO:0030036,GO:0030424,GO:0030659,GO:0031410,GO:0031434,GO:0031954,GO:0032147,GO:0032874,GO:0032956,GO:0038191,GO:0042981,GO:0043005,GO:0043235,GO:0044294,GO:0044295,GO:0046330,GO:0046777,GO:0048041,GO:0050775,GO:0051403,GO:0140059 activation of MAPKK activity|activation of MAPK activity|regulation of cell growth|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|ATP binding|intracellular|nucleus|nucleolus|cytosol|protein targeting to membrane|apoptotic process|response to stress|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|activation of JUN kinase activity|regulation of mitotic cell cycle|nervous system development|axonogenesis|regulation of cell shape|positive regulation of neuron projection development|actin cytoskeleton|integral component of membrane|cell migration|actin cytoskeleton organization|axon|cytoplasmic vesicle membrane|cytoplasmic vesicle|mitogen-activated protein kinase kinase binding|positive regulation of protein autophosphorylation|activation of protein kinase activity|positive regulation of stress-activated MAPK cascade|regulation of actin cytoskeleton organization|neuropilin binding|regulation of apoptotic process|neuron projection|receptor complex|dendritic growth cone|axonal growth cone|positive regulation of JNK cascade|protein autophosphorylation|focal adhesion assembly|positive regulation of dendrite morphogenesis|stress-activated MAPK cascade|dendrite arborization hsa04010 MAPK signaling pathway TAOK3 427.759590368167 429.044472079279 426.474708657055 0.994010496371693 -0.00866700871002597 0.98004433678072 1 2.12124 2.07799 2.17901 1.98419 GeneID:51347,Genbank:NM_016281.3,HGNC:HGNC:18133,MIM:616711 TAO kinase 3 GO:0000165,GO:0004674,GO:0004709,GO:0004860,GO:0005524,GO:0005737,GO:0005886,GO:0006281,GO:0006468,GO:0006974,GO:0007095,GO:0007399,GO:0016740,GO:0032874,GO:0042981,GO:0043507,GO:0046329,GO:0046330,GO:0046777 MAPK cascade|protein serine/threonine kinase activity|MAP kinase kinase kinase activity|protein kinase inhibitor activity|ATP binding|cytoplasm|plasma membrane|DNA repair|protein phosphorylation|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|nervous system development|transferase activity|positive regulation of stress-activated MAPK cascade|regulation of apoptotic process|positive regulation of JUN kinase activity|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation hsa04010 MAPK signaling pathway TAP1 1376.78285019939 1079.48351398199 1674.0821864168 1.55081774268275 0.633029145962624 0.416171457469747 1 14.2117 15.6249 34.5188 12.2606 GeneID:6890,Genbank:NM_000593.5,HGNC:HGNC:43,MIM:170260 transporter 1, ATP binding cassette subfamily B member hsa02010,hsa04145,hsa04612,hsa05163,hsa05168,hsa05169,hsa05170,hsa05340 ABC transporters|Phagosome|Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Primary immunodeficiency TAP2 1631.16432987876 1518.07947407188 1744.24918568563 1.14898410490137 0.200358839812936 0.714670120729697 1 10.0092 10.7426 16.5288 7.57446 GeneID:6891,Genbank:NM_018833.2,HGNC:HGNC:44,MIM:170261 transporter 2, ATP binding cassette subfamily B member hsa02010,hsa04145,hsa04612,hsa05163,hsa05168,hsa05169,hsa05170,hsa05340 ABC transporters|Phagosome|Antigen processing and presentation|Human cytomegalovirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Primary immunodeficiency TAPBP 5360.53453958327 5547.73587578933 5173.33320337721 0.932512527489632 -0.100804988044134 0.447704005976303 1 64.3138 61.8553 59.2293 58.432 GeneID:6892,Genbank:NM_172209.2,HGNC:HGNC:11566,MIM:601962 TAP binding protein hsa04612,hsa05163,hsa05169,hsa05170 Antigen processing and presentation|Human cytomegalovirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection TAPBPL 22.2829090048878 26.1462720922641 18.4195459175115 0.704480770815558 -0.505367766958052 0.412106128832194 1 0.216889 0.295824 0.215823 0.138613 GeneID:55080,Genbank:XM_017019546.2,HGNC:HGNC:30683,MIM:607081 TAP binding protein like GO:0000139,GO:0002376,GO:0002590,GO:0005789,GO:0005886,GO:0016021,GO:0032403 Golgi membrane|immune system process|negative regulation of antigen processing and presentation of peptide antigen via MHC class I|endoplasmic reticulum membrane|plasma membrane|integral component of membrane|protein complex binding TAPT1 537.724279664367 560.707949069829 514.740610258905 0.918019106226013 -0.123403914918567 0.511058725811747 1 4.62526 4.74724 4.93062 3.38801 GeneID:202018,Genbank:NM_153365.2,HGNC:HGNC:26887,MIM:612758 transmembrane anterior posterior transformation 1 GO:0001503,GO:0001701,GO:0005737,GO:0005813,GO:0009791,GO:0014032,GO:0016021,GO:0016520,GO:0030030,GO:0036064,GO:0045724,GO:0048706,GO:0051216,GO:0061036,GO:1903012 ossification|in utero embryonic development|cytoplasm|centrosome|post-embryonic development|neural crest cell development|integral component of membrane|growth hormone-releasing hormone receptor activity|cell projection organization|ciliary basal body|positive regulation of cilium assembly|embryonic skeletal system development|cartilage development|positive regulation of cartilage development|positive regulation of bone development TARBP1 529.148263704434 580.425458006854 477.871069402013 0.823311698013718 -0.280489370140065 0.107401486334575 1 4.68903 4.50567 4.16418 3.50559 GeneID:6894,Genbank:NM_005646.3,HGNC:HGNC:11568,MIM:605052 TAR (HIV-1) RNA binding protein 1 GO:0000453,GO:0003723,GO:0005634,GO:0006357,GO:0016423,GO:0030488,GO:0070039 enzyme-directed rRNA 2'-O-methylation|RNA binding|nucleus|regulation of transcription from RNA polymerase II promoter|tRNA (guanine) methyltransferase activity|tRNA methylation|rRNA (guanosine-2'-O-)-methyltransferase activity TARBP2 493.488674086502 531.458569432404 455.518778740601 0.857110610196939 -0.222446698617902 0.198742562139243 1 7.31726 7.7217 6.15554 6.92103 GeneID:6895,Genbank:NM_134323.1,HGNC:HGNC:11569,MIM:605053 TARBP2, RISC loading complex RNA binding subunit GO:0003725,GO:0005654,GO:0005737,GO:0005829,GO:0006469,GO:0007286,GO:0007338,GO:0010586,GO:0016442,GO:0016604,GO:0019899,GO:0030422,GO:0030423,GO:0031054,GO:0035068,GO:0035087,GO:0035196,GO:0035197,GO:0035264,GO:0035280,GO:0036002,GO:0042802,GO:0042803,GO:0045070,GO:0045727,GO:0046782,GO:0047485,GO:0048471,GO:0050689,GO:0070578,GO:0070883 double-stranded RNA binding|nucleoplasm|cytoplasm|cytosol|negative regulation of protein kinase activity|spermatid development|single fertilization|miRNA metabolic process|RISC complex|nuclear body|enzyme binding|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference|pre-miRNA processing|micro-ribonucleoprotein complex|siRNA loading onto RISC involved in RNA interference|production of miRNAs involved in gene silencing by miRNA|siRNA binding|multicellular organism growth|miRNA loading onto RISC involved in gene silencing by miRNA|pre-mRNA binding|identical protein binding|protein homodimerization activity|positive regulation of viral genome replication|positive regulation of translation|regulation of viral transcription|protein N-terminus binding|perinuclear region of cytoplasm|negative regulation of defense response to virus by host|RISC-loading complex|pre-miRNA binding TARDBP 3857.7656253713 4009.53201427016 3705.99923647243 0.924297205579745 -0.11357127347058 0.414639582792291 1 37.7196 35.1845 35.2797 32.4856 GeneID:23435,Genbank:NM_007375.3,HGNC:HGNC:11571,MIM:605078 TAR DNA binding protein GO:0001933,GO:0003690,GO:0003700,GO:0003723,GO:0003730,GO:0005634,GO:0005654,GO:0006366,GO:0006397,GO:0008380,GO:0010629,GO:0042802,GO:0042981,GO:0043922,GO:0051726,GO:0070935,GO:0071765 negative regulation of protein phosphorylation|double-stranded DNA binding|DNA binding transcription factor activity|RNA binding|mRNA 3'-UTR binding|nucleus|nucleoplasm|transcription from RNA polymerase II promoter|mRNA processing|RNA splicing|negative regulation of gene expression|identical protein binding|regulation of apoptotic process|negative regulation by host of viral transcription|regulation of cell cycle|3'-UTR-mediated mRNA stabilization|nuclear inner membrane organization TARM1 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:441864,Genbank:NM_001330650.1,HGNC:HGNC:37250,MIM:616802 T cell-interacting, activating receptor on myeloid cells 1 GO:0002250,GO:0005886,GO:0016021,GO:0034987,GO:0035579,GO:0043312,GO:0045087,GO:0070821,GO:2000515 adaptive immune response|plasma membrane|integral component of membrane|immunoglobulin receptor binding|specific granule membrane|neutrophil degranulation|innate immune response|tertiary granule membrane|negative regulation of CD4-positive, alpha-beta T cell activation TARS 4029.47808238091 4481.35474314207 3577.60142161975 0.798330332383224 -0.324942267887856 0.0170195535017321 0.540331203073832 50.8611 45.8111 39.8573 36.4396 GeneID:6897,Genbank:NM_001258437.1,HGNC:HGNC:11572,MIM:187790 threonyl-tRNA synthetase GO:0000049,GO:0004829,GO:0005524,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006435,GO:0015629,GO:0042803,GO:0070062 tRNA binding|threonine-tRNA ligase activity|ATP binding|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|threonyl-tRNA aminoacylation|actin cytoskeleton|protein homodimerization activity|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis TARS2 1264.52465780584 1203.56458022401 1325.48473538766 1.10129922163459 0.139206500617834 0.350579375251638 1 14.5826 14.7829 16.6466 15.4605 GeneID:80222,Genbank:NM_025150.4,HGNC:HGNC:30740,MIM:612805 threonyl-tRNA synthetase 2, mitochondrial GO:0002161,GO:0004829,GO:0005524,GO:0005739,GO:0005759,GO:0042803,GO:0070159 aminoacyl-tRNA editing activity|threonine-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|protein homodimerization activity|mitochondrial threonyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis TARSL2 108.813609317663 106.14154646919 111.485672166137 1.05034904685977 0.0708688369320721 0.829231759427702 1 0.791052 0.703162 0.91208 0.606587 GeneID:123283,Genbank:NM_152334.2,HGNC:HGNC:24728 threonyl-tRNA synthetase like 2 GO:0004829,GO:0005524,GO:0005737,GO:0006435 threonine-tRNA ligase activity|ATP binding|cytoplasm|threonyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis TAS1R1 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.00991991 0 0.0096907 GeneID:80835,Genbank:NM_138697.3,HGNC:HGNC:14448,MIM:606225 taste 1 receptor member 1 hsa04742 Taste transduction TAS1R3 7.52618613195264 7.78330750152491 7.26906476238037 0.933930049783619 -0.0986135969968167 1 1 0.127618 0.0671316 0.102068 0.109198 GeneID:83756,Genbank:XM_017002435.1,HGNC:HGNC:15661,MIM:605865 taste 1 receptor member 3 hsa04742,hsa04973 Taste transduction|Carbohydrate digestion and absorption TAS2R1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0493793 0 GeneID:50834,Genbank:NM_019599.2,HGNC:HGNC:14909,MIM:604796 taste 2 receptor member 1 GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0008527,GO:0016021,GO:0033038 detection of chemical stimulus involved in sensory perception of bitter taste|G-protein coupled receptor activity|plasma membrane|G-protein coupled receptor signaling pathway|taste receptor activity|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R14 0.780196841909191 1.07619535328461 0.484198330533773 0.449916763769675 -1.15226997256519 0.981239839765731 1 0.0641148 2.09775e-14 0.0696302 0.0692072 GeneID:50840,Genbank:NM_023922.1,HGNC:HGNC:14920,MIM:604790 taste 2 receptor member 14 GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0008527,GO:0016021,GO:0033038 detection of chemical stimulus involved in sensory perception of bitter taste|G-protein coupled receptor activity|plasma membrane|G-protein coupled receptor signaling pathway|taste receptor activity|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R19 1.27070322989325 2.05633815719933 0.48506830258717 0.235889365223771 -2.08381771694066 0.63179572723844 1 0 0 0 0 GeneID:259294,Genbank:NM_176888.2,HGNC:HGNC:19108,MIM:613961 taste 2 receptor member 19 GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0050909 G-protein coupled receptor activity|plasma membrane|G-protein coupled receptor signaling pathway|integral component of membrane|sensory perception of taste hsa04742 Taste transduction TAS2R20 8.46004260528922 9.64754055998448 7.27254465059396 0.753823692720051 -0.40770095518815 0.716509020554446 1 0.16309 0.250899 0.248242 0.0841108 GeneID:259295,Genbank:NM_176889.3,HGNC:HGNC:19109,MIM:613962 taste 2 receptor member 20 GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0033038 detection of chemical stimulus involved in sensory perception of bitter taste|G-protein coupled receptor activity|plasma membrane|G-protein coupled receptor signaling pathway|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R31 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0.0581509 0 0 0 GeneID:259290,Genbank:NM_176885.2,HGNC:HGNC:19113,MIM:612669 taste 2 receptor member 31 GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0016021,GO:0033038 detection of chemical stimulus involved in sensory perception of bitter taste|G-protein coupled receptor activity|plasma membrane|G-protein coupled receptor signaling pathway|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TAS2R4 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0675558 0 0 GeneID:50832,Genbank:NM_016944.1,HGNC:HGNC:14911,MIM:604869 taste 2 receptor member 4 hsa04742 Taste transduction TAS2R5 3.99030331009773 3.13253351048394 4.84807310971151 1.54765243324166 0.630081512089881 0.736640882078439 1 0.0545588 0.100478 0.360338 0.0955914 GeneID:54429,Genbank:NM_018980.2,HGNC:HGNC:14912,MIM:605062 taste 2 receptor member 5 GO:0001580,GO:0004930,GO:0005886,GO:0007186,GO:0007635,GO:0008527,GO:0016021,GO:0033038 detection of chemical stimulus involved in sensory perception of bitter taste|G-protein coupled receptor activity|plasma membrane|G-protein coupled receptor signaling pathway|chemosensory behavior|taste receptor activity|integral component of membrane|bitter taste receptor activity hsa04742 Taste transduction TASP1 133.633444054742 133.508092738794 133.75879537069 1.00187780850399 0.00270656460599741 0.986329525346266 1 1.56116 1.21725 1.37913 1.33512 GeneID:55617,Genbank:NM_001323602.1,HGNC:HGNC:15859,MIM:608270 taspase 1 GO:0004298,GO:0006508,GO:0042802,GO:0045893 threonine-type endopeptidase activity|proteolysis|identical protein binding|positive regulation of transcription, DNA-templated TAT 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0152915 0 GeneID:6898,Genbank:NM_000353.2,HGNC:HGNC:11573,MIM:613018 tyrosine aminotransferase GO:0004838,GO:0005739,GO:0005829,GO:0006103,GO:0006536,GO:0006559,GO:0006572,GO:0006979,GO:0009058,GO:0016597,GO:0030170,GO:0046689,GO:0051384,GO:0080130 L-tyrosine:2-oxoglutarate aminotransferase activity|mitochondrion|cytosol|2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process|response to oxidative stress|biosynthetic process|amino acid binding|pyridoxal phosphate binding|response to mercury ion|response to glucocorticoid|L-phenylalanine:2-oxoglutarate aminotransferase activity hsa00130,hsa00270,hsa00350,hsa00360,hsa00400 Ubiquinone and other terpenoid-quinone biosynthesis|Cysteine and methionine metabolism|Tyrosine metabolism|Phenylalanine metabolism|Phenylalanine, tyrosine and tryptophan biosynthesis TATDN1 351.419560515313 386.389659799627 316.449461231 0.818990501441223 -0.288081375137206 0.137934054968879 1 2.38103 1.72042 2.15816 1.57026 GeneID:83940,Genbank:NM_001146160.1,HGNC:HGNC:24220 TatD DNase domain containing 1 GO:0004536,GO:0005654,GO:0006308,GO:0016888,GO:0046872 deoxyribonuclease activity|nucleoplasm|DNA catabolic process|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding TATDN2 3249.38489726449 3242.87876787209 3255.89102665688 1.00401256405688 0.00577732306273273 0.980232736034302 1 24.8253 26.3978 28.0012 24.3383 GeneID:9797,Genbank:NM_014760.3,HGNC:HGNC:28988 TatD DNase domain containing 2 GO:0004536,GO:0005634,GO:0005654,GO:0005829,GO:0006308,GO:0016607,GO:0016888,GO:0036498,GO:0046872 deoxyribonuclease activity|nucleus|nucleoplasm|cytosol|DNA catabolic process|nuclear speck|endodeoxyribonuclease activity, producing 5'-phosphomonoesters|IRE1-mediated unfolded protein response|metal ion binding TATDN3 177.204869776661 177.04699527299 177.362744280332 1.00178341918119 0.00257063842632243 1 1 2.06716 2.33303 2.08337 2.31282 GeneID:128387,Genbank:NM_001146171.1,HGNC:HGNC:27010 TatD DNase domain containing 3 GO:0004518,GO:0005634,GO:0046872 nuclease activity|nucleus|metal ion binding TAX1BP1 1294.63638584736 1233.70684177023 1355.5659299245 1.09877475266281 0.135895666066418 0.34621920085889 1 10.1673 9.94718 11.7842 10.1243 GeneID:8887,Genbank:NM_001206901.1,HGNC:HGNC:11575,MIM:605326 Tax1 binding protein 1 GO:0005829,GO:0006915,GO:0010803,GO:0019900,GO:0032088,GO:0032480,GO:0043066,GO:0046872,GO:0070062 cytosol|apoptotic process|regulation of tumor necrosis factor-mediated signaling pathway|kinase binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of apoptotic process|metal ion binding|extracellular exosome hsa04137 Mitophagy - animal TAX1BP3 2128.4917255721 2080.59483827123 2176.38861287296 1.04604153237318 0.0649401339551132 0.658128573585226 1 72.2863 74.8006 76.2115 79.1181 GeneID:30851,Genbank:NM_001204698.1,HGNC:HGNC:30684,MIM:616484 Tax1 binding protein 3 GO:0001650,GO:0005634,GO:0005737,GO:0005886,GO:0007266,GO:0008013,GO:0008022,GO:0008285,GO:0015629,GO:0016055,GO:0030178,GO:0070062,GO:0090630,GO:2000009 fibrillar center|nucleus|cytoplasm|plasma membrane|Rho protein signal transduction|beta-catenin binding|protein C-terminus binding|negative regulation of cell proliferation|actin cytoskeleton|Wnt signaling pathway|negative regulation of Wnt signaling pathway|extracellular exosome|activation of GTPase activity|negative regulation of protein localization to cell surface TAZ 515.46341277608 496.894839612603 534.031985939557 1.07473844235514 0.103985595786134 0.564927918409172 1 4.68947 4.39172 4.70645 5.37674 GeneID:6901,Genbank:NM_001303465.1,HGNC:HGNC:11577,MIM:300394 tafazzin GO:0006644,GO:0016021,GO:0016746 phospholipid metabolic process|integral component of membrane|transferase activity, transferring acyl groups hsa00564 Glycerophospholipid metabolism TBC1D1 2676.01586560844 2550.26517643658 2801.76655478031 1.09861773617407 0.135689488143102 0.324179456129994 1 7.82341 8.37692 9.78242 8.65859 GeneID:23216,Genbank:NM_001253912.1,HGNC:HGNC:11578,MIM:609850 TBC1 domain family member 1 GO:0005096,GO:0005622,GO:0005634,GO:0005829,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0032880,GO:0061024,GO:0090630 GTPase activator activity|intracellular|nucleus|cytosol|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|regulation of protein localization|membrane organization|activation of GTPase activity hsa04152 AMPK signaling pathway TBC1D10A 244.779554490095 247.770147633158 241.788961347032 0.97585993977377 -0.0352539949411461 0.902175041842937 1 3.74953 4.91436 3.97003 5.11598 GeneID:83874,Genbank:NM_031937.2,HGNC:HGNC:23609,MIM:610020 TBC1 domain family member 10A GO:0005085,GO:0005096,GO:0005622,GO:0005829,GO:0005886,GO:0005902,GO:0006886,GO:0012505,GO:0017137,GO:0030165,GO:0031338,GO:0042147,GO:0045296,GO:0045862,GO:0070062,GO:0090630,GO:0097202 guanyl-nucleotide exchange factor activity|GTPase activator activity|intracellular|cytosol|plasma membrane|microvillus|intracellular protein transport|endomembrane system|Rab GTPase binding|PDZ domain binding|regulation of vesicle fusion|retrograde transport, endosome to Golgi|cadherin binding|positive regulation of proteolysis|extracellular exosome|activation of GTPase activity|activation of cysteine-type endopeptidase activity TBC1D10B 1256.58008878767 1083.01987500017 1430.14030257518 1.32051159502032 0.401096969437507 0.00737043310558426 0.340518730665856 13.8897 14.9298 20.2455 19.1929 GeneID:26000,Genbank:NM_015527.3,HGNC:HGNC:24510,MIM:613620 TBC1 domain family member 10B GO:0005096,GO:0005622,GO:0005829,GO:0005886,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0042147,GO:0043087,GO:0090630 GTPase activator activity|intracellular|cytosol|plasma membrane|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|retrograde transport, endosome to Golgi|regulation of GTPase activity|activation of GTPase activity TBC1D10C 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0 0 0 0 GeneID:374403,Genbank:XM_006718541.3,HGNC:HGNC:24702,MIM:610831 TBC1 domain family member 10C GO:0005096,GO:0005622,GO:0005829,GO:0005886,GO:0006886,GO:0012505,GO:0016020,GO:0017137,GO:0031338,GO:0031527,GO:0042147,GO:0043312,GO:0050869,GO:0051534,GO:0070373,GO:0090630,GO:0101003 GTPase activator activity|intracellular|cytosol|plasma membrane|intracellular protein transport|endomembrane system|membrane|Rab GTPase binding|regulation of vesicle fusion|filopodium membrane|retrograde transport, endosome to Golgi|neutrophil degranulation|negative regulation of B cell activation|negative regulation of NFAT protein import into nucleus|negative regulation of ERK1 and ERK2 cascade|activation of GTPase activity|ficolin-1-rich granule membrane TBC1D12 213.588416240856 223.612570113193 203.564262368519 0.910343556560684 -0.135516984951991 0.548038805137684 1 1.67947 1.73844 1.79662 1.33499 GeneID:23232,Genbank:NM_015188.1,HGNC:HGNC:29082 TBC1 domain family member 12 GO:0005096,GO:0005776,GO:0006886,GO:0017137,GO:0031338,GO:0055037,GO:0090630,GO:2000785 GTPase activator activity|autophagosome|intracellular protein transport|Rab GTPase binding|regulation of vesicle fusion|recycling endosome|activation of GTPase activity|regulation of autophagosome assembly TBC1D13 816.263683046711 750.478200484349 882.049165609073 1.17531617179528 0.233048908383952 0.145225021555605 1 7.40971 7.92867 9.77648 8.66489 GeneID:54662,Genbank:NM_018201.4,HGNC:HGNC:25571,MIM:616218 TBC1 domain family member 13 GO:0005096,GO:0005622,GO:0005829,GO:0006886,GO:0012505,GO:0016020,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|cytosol|intracellular protein transport|endomembrane system|membrane|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D14 2275.9186534585 2321.06971580311 2230.76759111388 0.961094609061326 -0.0572496396372255 0.681354524987963 1 15.4279 15.0433 15.235 14.2762 GeneID:57533,Genbank:NM_001113361.1,HGNC:HGNC:29246,MIM:614855 TBC1 domain family member 14 GO:0005096,GO:0005654,GO:0005776,GO:0005794,GO:0005829,GO:0006886,GO:0010507,GO:0017137,GO:0019901,GO:0031338,GO:0043231,GO:0055037,GO:0071955,GO:0090630,GO:2000785 GTPase activator activity|nucleoplasm|autophagosome|Golgi apparatus|cytosol|intracellular protein transport|negative regulation of autophagy|Rab GTPase binding|protein kinase binding|regulation of vesicle fusion|intracellular membrane-bounded organelle|recycling endosome|recycling endosome to Golgi transport|activation of GTPase activity|regulation of autophagosome assembly TBC1D15 207.384842392209 216.059585329985 198.710099454434 0.919700457403669 -0.12076403696241 0.611598457832192 1 1.1258 1.02186 1.11871 0.958297 GeneID:64786,Genbank:NM_001146214.1,HGNC:HGNC:25694,MIM:612662 TBC1 domain family member 15 GO:0005096,GO:0005622,GO:0005737,GO:0005739,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0043087,GO:0070062,GO:0090630 GTPase activator activity|intracellular|cytoplasm|mitochondrion|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|regulation of GTPase activity|extracellular exosome|activation of GTPase activity hsa04137 Mitophagy - animal TBC1D16 1831.66178155403 1762.63084430029 1900.69271880777 1.07832716359975 0.108794957027219 0.457650617998185 1 4.82164 5.2657 5.57854 5.42647 GeneID:125058,Genbank:XM_005257050.3,HGNC:HGNC:28356,MIM:616637 TBC1 domain family member 16 GO:0001919,GO:0005096,GO:0005769,GO:0005829,GO:0006886,GO:0017137,GO:0031338,GO:0090630 regulation of receptor recycling|GTPase activator activity|early endosome|cytosol|intracellular protein transport|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D17 968.243055797851 931.387932043206 1005.0981795525 1.07914022178448 0.109882338532541 0.482846811778784 1 10.4794 10.6749 11.5678 11.3935 GeneID:79735,Genbank:NM_024682.2,HGNC:HGNC:25699,MIM:616659 TBC1 domain family member 17 GO:0005096,GO:0005776,GO:0005829,GO:0006886,GO:0006914,GO:0012505,GO:0017137,GO:0031338,GO:0042147,GO:0055037,GO:0090630 GTPase activator activity|autophagosome|cytosol|intracellular protein transport|autophagy|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|retrograde transport, endosome to Golgi|recycling endosome|activation of GTPase activity hsa04137 Mitophagy - animal TBC1D19 68.7826696667081 74.0761999338609 63.4891393995553 0.857078784498147 -0.222500268868619 0.544094185879341 1 0.354964 0.434136 0.333701 0.233482 GeneID:55296,Genbank:NM_018317.3,HGNC:HGNC:25624 TBC1 domain family member 19 GO:0005096 GTPase activator activity TBC1D2 307.969008892773 304.809518358097 311.128499427449 1.02073091779873 0.0296025971447699 0.9075314366583 1 1.43076 1.48365 1.55626 1.50746 GeneID:55357,Genbank:NM_018421.3,HGNC:HGNC:18026,MIM:609871 TBC1 domain family member 2 GO:0005096,GO:0005634,GO:0005829,GO:0006886,GO:0012505,GO:0017137,GO:0030054,GO:0031338,GO:0031410,GO:0043547,GO:0045296,GO:0090630 GTPase activator activity|nucleus|cytosol|intracellular protein transport|endomembrane system|Rab GTPase binding|cell junction|regulation of vesicle fusion|cytoplasmic vesicle|positive regulation of GTPase activity|cadherin binding|activation of GTPase activity TBC1D20 1026.61226666741 1115.53605831702 937.688475017787 0.840572089110638 -0.25055654176434 0.0974767751708251 1 9.9202 10.0833 8.07007 8.89554 GeneID:128637,Genbank:NM_144628.3,HGNC:HGNC:16133,MIM:611663 TBC1 domain family member 20 GO:0001675,GO:0005096,GO:0005783,GO:0005789,GO:0006888,GO:0007030,GO:0017137,GO:0019068,GO:0030173,GO:0031965,GO:0033116,GO:0034389,GO:0043547,GO:0044829,GO:0046726,GO:0048208,GO:0070309,GO:0072520,GO:0090110,GO:1902953 acrosome assembly|GTPase activator activity|endoplasmic reticulum|endoplasmic reticulum membrane|ER to Golgi vesicle-mediated transport|Golgi organization|Rab GTPase binding|virion assembly|integral component of Golgi membrane|nuclear membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|lipid particle organization|positive regulation of GTPase activity|positive regulation by host of viral genome replication|positive regulation by virus of viral protein levels in host cell|COPII vesicle coating|lens fiber cell morphogenesis|seminiferous tubule development|cargo loading into COPII-coated vesicle|positive regulation of ER to Golgi vesicle-mediated transport TBC1D21 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00803191 0 0 0 GeneID:161514,Genbank:XM_006720409.4,HGNC:HGNC:28536 TBC1 domain family member 21 GO:0001669,GO:0003779,GO:0005096,GO:0005622,GO:0005856,GO:0006886,GO:0007283,GO:0012505,GO:0030154,GO:0031338,GO:0070062,GO:0090630 acrosomal vesicle|actin binding|GTPase activator activity|intracellular|cytoskeleton|intracellular protein transport|spermatogenesis|endomembrane system|cell differentiation|regulation of vesicle fusion|extracellular exosome|activation of GTPase activity TBC1D22A 433.497183403338 414.843227078478 452.151139728199 1.08993255816772 0.124238868023147 0.515781323727236 1 1.05612 1.27074 1.37552 1.34656 GeneID:25771,Genbank:NM_001284304.1,HGNC:HGNC:1309,MIM:616879 TBC1 domain family member 22A GO:0005096,GO:0005622,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0042803,GO:0071889,GO:0090630 GTPase activator activity|intracellular|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|protein homodimerization activity|14-3-3 protein binding|activation of GTPase activity TBC1D22B 680.439276497166 665.936996320005 694.941556674328 1.0435545111844 0.0615059631823326 0.708605326095972 1 5.53245 5.61552 5.94365 6.01546 GeneID:55633,Genbank:NM_017772.3,HGNC:HGNC:21602,MIM:616880 TBC1 domain family member 22B GO:0005096,GO:0005622,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0071889,GO:0090630 GTPase activator activity|intracellular|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|14-3-3 protein binding|activation of GTPase activity TBC1D23 338.269160109481 345.50201102821 331.036309190751 0.958131352710772 -0.0617046425645389 0.911324717434232 1 4.13777 2.64545 3.78499 2.79301 GeneID:55773,Genbank:NM_001199198.2,HGNC:HGNC:25622,MIM:617687 TBC1 domain family member 23 GO:0005794,GO:0005802,GO:0005829,GO:0007420,GO:0016192,GO:0031175,GO:0032680,GO:0032755,GO:0042147,GO:0050727,GO:0071203,GO:1990403 Golgi apparatus|trans-Golgi network|cytosol|brain development|vesicle-mediated transport|neuron projection development|regulation of tumor necrosis factor production|positive regulation of interleukin-6 production|retrograde transport, endosome to Golgi|regulation of inflammatory response|WASH complex|embryonic brain development TBC1D24 346.691741326542 342.534190652852 350.849292000233 1.02427524484938 0.0346034507095286 0.857021362951633 1 2.48026 2.2937 2.3018 2.6737 GeneID:57465,Genbank:XM_017023493.1,HGNC:HGNC:29203,MIM:613577 TBC1 domain family member 24 GO:0005096,GO:0005737,GO:0005886,GO:0030054,GO:0031175,GO:0031594,GO:0043195 GTPase activator activity|cytoplasm|plasma membrane|cell junction|neuron projection development|neuromuscular junction|terminal bouton TBC1D25 492.937491693294 524.539734875209 461.33524851138 0.879504864624096 -0.185236537486146 0.289655648822319 1 5.13403 5.0381 4.06486 4.69905 GeneID:4943,Genbank:NM_001348265.1,HGNC:HGNC:8092,MIM:311240 TBC1 domain family member 25 GO:0005096,GO:0005776,GO:0006886,GO:0006914,GO:0012505,GO:0017137,GO:0031338,GO:0031410,GO:0090630,GO:1901096 GTPase activator activity|autophagosome|intracellular protein transport|autophagy|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|cytoplasmic vesicle|activation of GTPase activity|regulation of autophagosome maturation TBC1D26 0.732170567224248 0.980142803914724 0.484198330533773 0.494007943128152 -1.01739385587201 0.981054425361989 1 0 0.0382618 0 0 GeneID:353149,Genbank:NM_178571.4,HGNC:HGNC:28745 TBC1 domain family member 26 GO:0005096,GO:0005622,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D2B 1146.83689084229 1097.61615585441 1196.05762583018 1.08968660806485 0.123913278121276 0.427898213387655 1 6.62834 7.53344 8.11205 7.73071 GeneID:23102,Genbank:XM_011521387.2,HGNC:HGNC:29183 TBC1 domain family member 2B GO:0005096,GO:0005622,GO:0005829,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|cytosol|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D3 6.24831777875051 9.58970563019159 2.90692992730943 0.30313025648644 -1.72199023516236 0.447735587493378 1 0.0175717 0.0156691 0.0328834 0 GeneID:729873,Genbank:NM_001123391.3,HGNC:HGNC:19031,MIM:607741 TBC1 domain family member 3 GO:0005096,GO:0005622,GO:0005886,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|plasma membrane|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D30 91.2441583395939 111.244174242612 71.2441424365762 0.640430322950668 -0.642886477016201 0.0375761829251041 0.744558420459959 0.458465 0.468244 0.341517 0.260883 GeneID:23329,Genbank:NM_001330187.1,HGNC:HGNC:29164,MIM:615077 TBC1 domain family member 30 GO:0005096,GO:0005829,GO:0005886,GO:0005929,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0036064,GO:0043547,GO:0090630,GO:1902018 GTPase activator activity|cytosol|plasma membrane|cilium|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|ciliary basal body|positive regulation of GTPase activity|activation of GTPase activity|negative regulation of cilium assembly TBC1D31 150.453186283712 166.179180535666 134.727192031758 0.810734483089124 -0.302698588151514 0.232988889168002 1 0.908999 0.968983 0.880516 0.802275 GeneID:93594,Genbank:XM_017013984.1,HGNC:HGNC:30888 TBC1 domain family member 31 GO:0005813 centrosome TBC1D32 27.760588248248 31.7771888872198 23.7439876092762 0.747202268065494 -0.420429260661691 0.446403904442909 1 0.0420541 0.0712385 0.0407831 0.0620532 GeneID:221322,Genbank:XM_011535571.3,HGNC:HGNC:21485,MIM:615867 TBC1 domain family member 32 GO:0002088,GO:0003406,GO:0005737,GO:0005929,GO:0007368,GO:0007507,GO:0042733,GO:0060831,GO:0061512,GO:1905515 lens development in camera-type eye|retinal pigment epithelium development|cytoplasm|cilium|determination of left/right symmetry|heart development|embryonic digit morphogenesis|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|protein localization to cilium|non-motile cilium assembly TBC1D3B 2.79144526013538 5.58289052027075 0 0 -Inf 0.0461054820862989 0.79332376136203 0.0192853 0.13663 0 0 GeneID:414059,Genbank:NM_001001417.6,HGNC:HGNC:27011,MIM:610144 TBC1 domain family member 3B GO:0005096,GO:0005622,GO:0005886,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|plasma membrane|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D3C 3.90632352312662 5.39078542153098 2.42186162472226 0.449259511433948 -1.15437904701563 0.661849201523983 1 0 0.0806293 0.0212998 0.019919 GeneID:414060,Genbank:NM_001001418.6,HGNC:HGNC:24889,MIM:610806 TBC1 domain family member 3C GO:0005096,GO:0005622,GO:0005886,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|plasma membrane|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D3D 0.996651292201907 0.538097676642304 1.45520490776151 2.70435084730694 1.43528233092293 0.835161298535314 1 0 0 0.00948107 0 GeneID:101060389,Genbank:NM_001291465.1,HGNC:HGNC:28944,MIM:610807 TBC1 domain family member 3D GO:0005096,GO:0005622,GO:0005886,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|plasma membrane|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D3E 1.96841947500795 1.02816907859967 2.90866987141623 2.8289801083862 1.50028203264315 0.612213169729345 1 0 0.014553 0.0151814 0.0141518 GeneID:102723859,Genbank:XM_006722254.2,HGNC:HGNC:27071,MIM:610808 TBC1 domain family member 3E GO:0005096,GO:0005622,GO:0005886,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|plasma membrane|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D3F 4.22677015787121 6.51500704950053 1.93853326624189 0.297548913073011 -1.74880124714765 0.260575535915009 1 0.039677 0.123343 0 0.0345765 GeneID:84218,Genbank:NM_032258.4,HGNC:HGNC:18257,MIM:610809 TBC1 domain family member 3F GO:0005096,GO:0005622,GO:0005886,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|plasma membrane|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D3G 2.95443535034626 3.96859749034384 1.94027321034868 0.488906525559632 -1.03236943339549 0.654643136065348 1 0.0106416 0.0383366 0 0 GeneID:101060321,Genbank:XM_005276914.3,HGNC:HGNC:29860,MIM:610810 TBC1 domain family member 3G GO:0005096,GO:0005622,GO:0005886,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|plasma membrane|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D3I 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0 0 0 0.00994463 GeneID:102724862,Genbank:XM_006722223.3,HGNC:HGNC:32709 TBC1 domain family member 3I GO:0005096,GO:0005622,GO:0005886,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|plasma membrane|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D3K 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:101060351,Genbank:XM_006722235.2,HGNC:HGNC:51245 TBC1 domain family member 3K GO:0005096,GO:0005622,GO:0005886,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|plasma membrane|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D3L 33.9257721911008 38.2823872816124 29.5691571005892 0.772395850945058 -0.372587680258388 0.473011890397245 1 0.370861 0.3576 0.399556 0.211977 GeneID:101060376,Genbank:XM_006722242.4,HGNC:HGNC:51246 TBC1 domain family member 3L GO:0005096,GO:0005622,GO:0005886,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|plasma membrane|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D4 367.955080951141 419.906620231467 316.003541670816 0.752556702956061 -0.41012780604951 0.0292529572137489 0.677045321871968 1.35944 1.46411 1.16505 0.935225 GeneID:9882,Genbank:NM_001286659.2,HGNC:HGNC:19165,MIM:612465 TBC1 domain family member 4 GO:0005096,GO:0005622,GO:0005829,GO:0006886,GO:0012505,GO:0016192,GO:0017137,GO:0030659,GO:0031338,GO:0031339,GO:0032869,GO:0061024,GO:0070062,GO:0090630 GTPase activator activity|intracellular|cytosol|intracellular protein transport|endomembrane system|vesicle-mediated transport|Rab GTPase binding|cytoplasmic vesicle membrane|regulation of vesicle fusion|negative regulation of vesicle fusion|cellular response to insulin stimulus|membrane organization|extracellular exosome|activation of GTPase activity hsa04919,hsa04931 Thyroid hormone signaling pathway|Insulin resistance TBC1D5 2038.74079181881 2200.46412464692 1877.01745899071 0.853009798236038 -0.229365781496957 0.107871651808615 1 9.10365 8.35328 7.86713 6.93594 GeneID:9779,Genbank:NM_001349091.1,HGNC:HGNC:19166,MIM:615740 TBC1 domain family member 5 GO:0002092,GO:0005096,GO:0005776,GO:0005794,GO:0005829,GO:0006886,GO:0006914,GO:0010008,GO:0016236,GO:0017137,GO:0030904,GO:0031338,GO:0035612,GO:0042147,GO:0042594,GO:0043231,GO:0090630,GO:1905394 positive regulation of receptor internalization|GTPase activator activity|autophagosome|Golgi apparatus|cytosol|intracellular protein transport|autophagy|endosome membrane|macroautophagy|Rab GTPase binding|retromer complex|regulation of vesicle fusion|AP-2 adaptor complex binding|retrograde transport, endosome to Golgi|response to starvation|intracellular membrane-bounded organelle|activation of GTPase activity|retromer complex binding TBC1D7 8.50219580855057 8.76345030543964 8.24094131166151 0.940376338591913 -0.0886898560086835 1 1 1.64304 1.78265 1.64508 1.86967 GeneID:51256,Genbank:NM_001143966.3,HGNC:HGNC:21066,MIM:612655 TBC1 domain family member 7 GO:0005096,GO:0005829,GO:0017137,GO:0031398,GO:0031410,GO:0032007,GO:0036064,GO:0043547,GO:0070848,GO:0090630,GO:1902018 GTPase activator activity|cytosol|Rab GTPase binding|positive regulation of protein ubiquitination|cytoplasmic vesicle|negative regulation of TOR signaling|ciliary basal body|positive regulation of GTPase activity|response to growth factor|activation of GTPase activity|negative regulation of cilium assembly hsa04150 mTOR signaling pathway TBC1D7-LOC100130357 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 3.06033 4.01147 3.07608 3.36105 GeneID:107080638,Genbank:NM_001318809.1 TBC1D7-LOC100130357 readthrough GO:0005096,GO:0005829,GO:0017137,GO:0031398,GO:0031410,GO:0032007,GO:0036064,GO:0043547,GO:0070848,GO:0090630,GO:1902018 GTPase activator activity|cytosol|Rab GTPase binding|positive regulation of protein ubiquitination|cytoplasmic vesicle|negative regulation of TOR signaling|ciliary basal body|positive regulation of GTPase activity|response to growth factor|activation of GTPase activity|negative regulation of cilium assembly hsa04150 mTOR signaling pathway TBC1D8 322.965347119147 335.788860885034 310.14183335326 0.923621565455814 -0.114626236183156 0.559813118491398 1 1.77187 1.82938 1.49226 1.80213 GeneID:11138,Genbank:XM_005263862.4,HGNC:HGNC:17791 TBC1 domain family member 8 GO:0005096,GO:0005622,GO:0006886,GO:0008015,GO:0008284,GO:0012505,GO:0016020,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|intracellular|intracellular protein transport|blood circulation|positive regulation of cell proliferation|endomembrane system|membrane|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D8B 78.5278334055394 78.5250601710542 78.5306066400245 1.00007063310691 0.000101898434405411 0.998388058101366 1 0.510059 0.418794 0.635438 0.316973 GeneID:54885,Genbank:NM_017752.2,HGNC:HGNC:24715 TBC1 domain family member 8B GO:0005096,GO:0005509,GO:0005622,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|calcium ion binding|intracellular|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D9 932.301922065938 838.015633988521 1026.58821014336 1.22502274242466 0.292808532965566 0.218561597188561 1 5.34698 5.12791 7.94036 5.53006 GeneID:23158,Genbank:NM_015130.2,HGNC:HGNC:21710 TBC1 domain family member 9 GO:0005096,GO:0005509,GO:0005622,GO:0006886,GO:0012505,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|calcium ion binding|intracellular|intracellular protein transport|endomembrane system|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBC1D9B 5481.44270793442 4751.01476908248 6211.87064678635 1.30748291653616 0.386792096461074 0.00383245740529676 0.238835166549544 29.0695 31.4425 40.4514 40.2459 GeneID:23061,Genbank:NM_015043.3,HGNC:HGNC:29097 TBC1 domain family member 9B GO:0005096,GO:0005509,GO:0005622,GO:0006886,GO:0012505,GO:0016021,GO:0017137,GO:0031338,GO:0090630 GTPase activator activity|calcium ion binding|intracellular|intracellular protein transport|endomembrane system|integral component of membrane|Rab GTPase binding|regulation of vesicle fusion|activation of GTPase activity TBCA 3657.39853419041 3835.02670490549 3479.77036347533 0.907365353942453 -0.140244520772503 0.401202645525406 1 36.2953 40.7062 31.7824 37.2068 GeneID:6902,Genbank:NM_001297740.1,HGNC:HGNC:11579,MIM:610058 tubulin folding cofactor A GO:0003723,GO:0005730,GO:0005737,GO:0005874,GO:0006457,GO:0007021,GO:0007023,GO:0015630,GO:0048487,GO:0051087,GO:0070062 RNA binding|nucleolus|cytoplasm|microtubule|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|microtubule cytoskeleton|beta-tubulin binding|chaperone binding|extracellular exosome TBCB 2546.96582309269 2665.12519793909 2428.8064482463 0.911329212648046 -0.133955781082599 0.332278735930244 1 72.0962 77.5738 65.3318 72.2806 GeneID:1155,Genbank:NM_001281.2,HGNC:HGNC:1989,MIM:601303 tubulin folding cofactor B GO:0005737,GO:0005829,GO:0005874,GO:0007399,GO:0015630,GO:0030154 cytoplasm|cytosol|microtubule|nervous system development|microtubule cytoskeleton|cell differentiation TBCC 799.964621653844 779.977520150306 819.951723157381 1.05125045526873 0.0721064252735612 0.653442227048379 1 24.3265 23.9829 24.9121 26.3925 GeneID:6903,Genbank:NM_003192.2,HGNC:HGNC:11580,MIM:602971 tubulin folding cofactor C GO:0003924,GO:0005737,GO:0005829,GO:0005856,GO:0005874,GO:0006457,GO:0007021,GO:0007023,GO:0015631,GO:0032391,GO:0051087 GTPase activity|cytoplasm|cytosol|cytoskeleton|microtubule|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|tubulin binding|photoreceptor connecting cilium|chaperone binding TBCCD1 467.32014618494 521.733576632411 412.906715737468 0.791412962919929 -0.33749739881211 0.0580908839225454 0.875517516166731 6.60749 6.56775 5.56497 5.15425 GeneID:55171,Genbank:NM_001286749.1,HGNC:HGNC:25546 TBCC domain containing 1 GO:0005737,GO:0008360,GO:0030334,GO:0031616,GO:0051661,GO:0051684 cytoplasm|regulation of cell shape|regulation of cell migration|spindle pole centrosome|maintenance of centrosome location|maintenance of Golgi location TBCD 2765.72918366535 2639.71792027646 2891.74044705425 1.09547327949018 0.131554294901253 0.348000736508145 1 7.41357 7.88498 8.8752 8.57563 GeneID:6904,Genbank:XM_005256396.4,HGNC:HGNC:11581,MIM:604649 tubulin folding cofactor D GO:0000278,GO:0005096,GO:0005737,GO:0005813,GO:0005874,GO:0005912,GO:0005923,GO:0006457,GO:0007021,GO:0007023,GO:0010812,GO:0016328,GO:0031115,GO:0034333,GO:0048487,GO:0048667,GO:0051087,GO:0070830 mitotic cell cycle|GTPase activator activity|cytoplasm|centrosome|microtubule|adherens junction|bicellular tight junction|protein folding|tubulin complex assembly|post-chaperonin tubulin folding pathway|negative regulation of cell-substrate adhesion|lateral plasma membrane|negative regulation of microtubule polymerization|adherens junction assembly|beta-tubulin binding|cell morphogenesis involved in neuron differentiation|chaperone binding|bicellular tight junction assembly TBCE 615.242691126851 652.820738326742 577.664643926961 0.884874836249204 -0.176454691548022 0.289447947212466 1 7.89079 8.10615 7.01589 7.45501 GeneID:6905,Genbank:NM_001079515.2,HGNC:HGNC:11582,MIM:604934 tubulin folding cofactor E GO:0000226,GO:0005737,GO:0005874,GO:0006457,GO:0007023,GO:0007052,GO:0008344,GO:0009791,GO:0014889,GO:0048589,GO:0048936,GO:0051087 microtubule cytoskeleton organization|cytoplasm|microtubule|protein folding|post-chaperonin tubulin folding pathway|mitotic spindle organization|adult locomotory behavior|post-embryonic development|muscle atrophy|developmental growth|peripheral nervous system neuron axonogenesis|chaperone binding TBCEL 336.332035619822 343.082096984602 329.581974255043 0.960650459909702 -0.0579165041451329 0.769172594071884 1 2.5607 2.69495 2.8954 2.16108 GeneID:219899,Genbank:NM_152715.4,HGNC:HGNC:28115,MIM:610451 tubulin folding cofactor E like GO:0005737,GO:0005856 cytoplasm|cytoskeleton TBCK 172.796734366649 188.078506144585 157.514962588714 0.837495819259776 -0.255846106278239 0.278886028293457 1 0.822246 1.02751 0.804779 0.684528 GeneID:93627,Genbank:NM_001163436.2,HGNC:HGNC:28261,MIM:616899 TBC1 domain containing kinase GO:0004672,GO:0005096,GO:0005524,GO:0005737,GO:0006886,GO:0008283,GO:0012505,GO:0017137,GO:0030036,GO:0030496,GO:0031338,GO:0032006,GO:0072686,GO:0090630 protein kinase activity|GTPase activator activity|ATP binding|cytoplasm|intracellular protein transport|cell proliferation|endomembrane system|Rab GTPase binding|actin cytoskeleton organization|midbody|regulation of vesicle fusion|regulation of TOR signaling|mitotic spindle|activation of GTPase activity TBK1 247.8626618501 264.037539446267 231.687784253934 0.877480470162783 -0.188561078772554 0.456605223296648 1 2.73468 2.48635 2.878 1.88732 GeneID:29110,Genbank:NM_013254.3,HGNC:HGNC:11584,MIM:604834 TANK binding kinase 1 GO:0003676,GO:0004672,GO:0004674,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0006954,GO:0007249,GO:0009615,GO:0010008,GO:0010629,GO:0016032,GO:0016235,GO:0016239,GO:0018105,GO:0018107,GO:0032479,GO:0032480,GO:0032481,GO:0032606,GO:0032727,GO:0032728,GO:0033138,GO:0035666,GO:0042802,GO:0043123,GO:0044565,GO:0045087,GO:0045359,GO:0045944,GO:0050830,GO:0051219,GO:0051607,GO:0071345,GO:1901214,GO:1904417 nucleic acid binding|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|inflammatory response|I-kappaB kinase/NF-kappaB signaling|response to virus|endosome membrane|negative regulation of gene expression|viral process|aggresome|positive regulation of macroautophagy|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of type I interferon production|negative regulation of type I interferon production|positive regulation of type I interferon production|type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of peptidyl-serine phosphorylation|TRIF-dependent toll-like receptor signaling pathway|identical protein binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|dendritic cell proliferation|innate immune response|positive regulation of interferon-beta biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|defense response to Gram-positive bacterium|phosphoprotein binding|defense response to virus|cellular response to cytokine stimulus|regulation of neuron death|positive regulation of xenophagy hsa04014,hsa04137,hsa04620,hsa04621,hsa04622,hsa04623,hsa04657,hsa05160,hsa05161,hsa05162,hsa05163,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169,hsa05170 Ras signaling pathway|Mitophagy - animal|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|IL-17 signaling pathway|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection TBKBP1 105.254269345879 103.412840466402 107.095698225357 1.03561315734434 0.0504851997392748 0.886820025916343 1 0.856563 0.845823 0.896418 0.996285 GeneID:9755,Genbank:XM_005257862.3,HGNC:HGNC:30140,MIM:608476 TBK1 binding protein 1 GO:0016032,GO:0045087 viral process|innate immune response hsa04622 RIG-I-like receptor signaling pathway TBL1X 402.569584198003 344.706198669637 460.43296972637 1.33572581956278 0.417623900512644 0.0241157028201676 0.621959897532696 2.24224 2.34673 3.30775 2.65207 GeneID:6907,Genbank:NM_001139468.1,HGNC:HGNC:11585,MIM:300196 transducin beta like 1 X-linked GO:0000122,GO:0003714,GO:0005634,GO:0005654,GO:0005876,GO:0006351,GO:0006508,GO:0007605,GO:0008013,GO:0008022,GO:0008134,GO:0016575,GO:0017053,GO:0019216,GO:0019904,GO:0042393,GO:0042802,GO:0043161,GO:0044212,GO:0045893,GO:0045944,GO:0090263 negative regulation of transcription from RNA polymerase II promoter|transcription corepressor activity|nucleus|nucleoplasm|spindle microtubule|transcription, DNA-templated|proteolysis|sensory perception of sound|beta-catenin binding|protein C-terminus binding|transcription factor binding|histone deacetylation|transcriptional repressor complex|regulation of lipid metabolic process|protein domain specific binding|histone binding|identical protein binding|proteasome-mediated ubiquitin-dependent protein catabolic process|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt signaling pathway hsa04310 Wnt signaling pathway TBL1XR1 1302.70280694951 1345.22936500584 1260.17624889318 0.936774264430146 -0.0942266530031934 0.615850779165241 1 6.67464 6.37375 7.07466 5.18495 GeneID:79718,Genbank:NM_024665.5,HGNC:HGNC:29529,MIM:608628 transducin beta like 1 X-linked receptor 1 GO:0000122,GO:0002021,GO:0003714,GO:0005634,GO:0005654,GO:0005876,GO:0006351,GO:0008013,GO:0016042,GO:0016575,GO:0017053,GO:0019216,GO:0030814,GO:0035264,GO:0042393,GO:0043161,GO:0044212,GO:0045893,GO:0045944,GO:0047485,GO:0050872,GO:0060613,GO:0090207,GO:0090263 negative regulation of transcription from RNA polymerase II promoter|response to dietary excess|transcription corepressor activity|nucleus|nucleoplasm|spindle microtubule|transcription, DNA-templated|beta-catenin binding|lipid catabolic process|histone deacetylation|transcriptional repressor complex|regulation of lipid metabolic process|regulation of cAMP metabolic process|multicellular organism growth|histone binding|proteasome-mediated ubiquitin-dependent protein catabolic process|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein N-terminus binding|white fat cell differentiation|fat pad development|regulation of triglyceride metabolic process|positive regulation of canonical Wnt signaling pathway hsa04310 Wnt signaling pathway TBL2 1556.33518560724 1549.79882802931 1562.87154318517 1.00843510455643 0.0121182457287261 0.945175287531053 1 14.2027 14.9447 14.9511 15.359 GeneID:26608,Genbank:NM_012453.2,HGNC:HGNC:11586,MIM:605842 transducin beta like 2 GO:0003723,GO:0005783,GO:0019901,GO:0030176,GO:0030968,GO:0031369,GO:0042149,GO:0051219,GO:0071456 RNA binding|endoplasmic reticulum|protein kinase binding|integral component of endoplasmic reticulum membrane|endoplasmic reticulum unfolded protein response|translation initiation factor binding|cellular response to glucose starvation|phosphoprotein binding|cellular response to hypoxia TBL3 788.213432924333 783.658976993395 792.767888855271 1.01162356602718 0.0166725504516123 0.965311719004648 1 13.155 14.1314 12.8549 15.2746 GeneID:10607,Genbank:NM_006453.2,HGNC:HGNC:11587,MIM:605915 transducin beta like 3 GO:0000462,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0030515,GO:0032040,GO:0034388 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleoplasm|nucleolus|rRNA processing|snoRNA binding|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome hsa03008 Ribosome biogenesis in eukaryotes TBP 572.325389309841 599.942070190887 544.708708428795 0.907935508265794 -0.139338270068835 0.410298534134575 1 12.7466 13.7427 12.0563 11.9649 GeneID:6908,Genbank:NM_003194.4,HGNC:HGNC:11588,MIM:600075 TATA-box binding protein GO:0000790,GO:0000978,GO:0000987,GO:0001034,GO:0001047,GO:0001093,GO:0001103,GO:0001129,GO:0001939,GO:0001940,GO:0005634,GO:0005654,GO:0005669,GO:0005672,GO:0005719,GO:0005737,GO:0006361,GO:0006362,GO:0006363,GO:0006366,GO:0006367,GO:0006368,GO:0006383,GO:0007283,GO:0008134,GO:0016032,GO:0017162,GO:0019899,GO:0042795,GO:0043234,GO:0044212,GO:0045815,GO:0045893,GO:0051123,GO:0070491,GO:0097550,GO:1901796 nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|proximal promoter sequence-specific DNA binding|RNA polymerase III transcription factor activity, sequence-specific DNA binding|core promoter binding|TFIIB-class transcription factor binding|RNA polymerase II repressing transcription factor binding|RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly|female pronucleus|male pronucleus|nucleus|nucleoplasm|transcription factor TFIID complex|transcription factor TFIIA complex|nuclear euchromatin|cytoplasm|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|spermatogenesis|transcription factor binding|viral process|aryl hydrocarbon receptor binding|enzyme binding|snRNA transcription from RNA polymerase II promoter|protein complex|transcription regulatory region DNA binding|positive regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|RNA polymerase II transcriptional preinitiation complex assembly|repressing transcription factor binding|transcriptional preinitiation complex|regulation of signal transduction by p53 class mediator hsa03022,hsa05016,hsa05165,hsa05166,hsa05168,hsa05203 Basal transcription factors|Huntington disease|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Herpes simplex infection|Viral carcinogenesis TBPL1 364.572679476629 375.339548618671 353.805810334586 0.942628645546855 -0.0852385708007584 0.662444461336592 1 7.78299 7.55622 8.02062 6.66443 GeneID:9519,Genbank:NM_001253676.1,HGNC:HGNC:11589,MIM:605521 TATA-box binding protein like 1 GO:0003677,GO:0005634,GO:0005737,GO:0006352,GO:0006355 DNA binding|nucleus|cytoplasm|DNA-templated transcription, initiation|regulation of transcription, DNA-templated hsa03022,hsa05016,hsa05165,hsa05166,hsa05168,hsa05203 Basal transcription factors|Huntington disease|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Herpes simplex infection|Viral carcinogenesis TBR1 1.0012194055454 1.51824048055703 0.484198330533773 0.31892070902768 -1.64873031325362 0.791516662337547 1 0.0134412 0.0241325 0 0.0117725 GeneID:10716,Genbank:NM_006593.3,HGNC:HGNC:11590,MIM:604616 T-box, brain 1 GO:0000978,GO:0001661,GO:0003700,GO:0005634,GO:0006351,GO:0007420,GO:0010092,GO:0019901,GO:0021764,GO:0021902,GO:0021987,GO:0030902,GO:0045944,GO:1902667 RNA polymerase II proximal promoter sequence-specific DNA binding|conditioned taste aversion|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|brain development|specification of animal organ identity|protein kinase binding|amygdala development|commitment of neuronal cell to specific neuron type in forebrain|cerebral cortex development|hindbrain development|positive regulation of transcription from RNA polymerase II promoter|regulation of axon guidance TBRG1 630.386996615491 647.698493243105 613.075499987877 0.946544582677866 -0.0792576357692518 0.64921018154968 1 3.47167 3.30543 3.35592 3.0997 GeneID:84897,Genbank:NM_032811.2,HGNC:HGNC:29551,MIM:610614 transforming growth factor beta regulator 1 GO:0005634,GO:0006260,GO:0007050,GO:0008285,GO:0050821,GO:1990173 nucleus|DNA replication|cell cycle arrest|negative regulation of cell proliferation|protein stabilization|protein localization to nucleoplasm TBRG4 2366.56949389406 2483.13047937269 2250.00850841543 0.906117711939103 -0.142229614814889 0.359662812762764 1 41.9366 47.2106 40.7854 42.9036 GeneID:9238,Genbank:NM_199122.2,HGNC:HGNC:17443,MIM:611325 transforming growth factor beta regulator 4 GO:0003723,GO:0004672,GO:0005739,GO:0005759,GO:0007050,GO:0008284,GO:0016071,GO:0044528,GO:0045333,GO:0090615 RNA binding|protein kinase activity|mitochondrion|mitochondrial matrix|cell cycle arrest|positive regulation of cell proliferation|mRNA metabolic process|regulation of mitochondrial mRNA stability|cellular respiration|mitochondrial mRNA processing TBX15 8.61585466599642 7.05310472614284 10.17860460585 1.44313816412257 0.529209428139869 0.651767050422497 1 0.0340074 0.0780763 0.0884712 0.0524585 GeneID:6913,Genbank:NM_152380.2,HGNC:HGNC:11594,MIM:604127 T-box 15 GO:0000978,GO:0001078,GO:0001106,GO:0006351,GO:0042803,GO:0046982,GO:0048701,GO:0070722 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription corepressor activity|transcription, DNA-templated|protein homodimerization activity|protein heterodimerization activity|embryonic cranial skeleton morphogenesis|Tle3-Aes complex TBX19 65.2109047718673 61.1040207646527 69.3177887790819 1.13442270920379 0.181958318268135 0.650519940649644 1 0.861562 0.850648 1.15231 0.671922 GeneID:9095,Genbank:NM_005149.2,HGNC:HGNC:11596,MIM:604614 T-box 19 GO:0000978,GO:0001077,GO:0001158,GO:0005634,GO:0006357,GO:0009653,GO:0021983,GO:0042127,GO:0045165,GO:0045595 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|enhancer sequence-specific DNA binding|nucleus|regulation of transcription from RNA polymerase II promoter|anatomical structure morphogenesis|pituitary gland development|regulation of cell proliferation|cell fate commitment|regulation of cell differentiation TBX2 307.39625342275 224.208502719628 390.584004125871 1.74205705576784 0.800791875788287 6.35145102733548e-05 0.0184954253916009 3.37162 3.35241 5.67197 6.46922 GeneID:6909,Genbank:NM_005994.3,HGNC:HGNC:11597,MIM:600747 T-box 2 TBX3 1386.86735457254 1518.94293001536 1254.79177912973 0.826095407756397 -0.275619683281051 0.0600400025263238 0.879410748501007 14.8829 14.0549 13.1901 10.9037 GeneID:6926,Genbank:NM_005996.3,HGNC:HGNC:11602,MIM:601621 T-box 3 hsa04550 Signaling pathways regulating pluripotency of stem cells TBX4 0.998282869833606 1.02816907859967 0.968396661067546 0.941865186596032 -0.0864075197076174 1 1 0.0103661 0.0092893 0 0.00907898 GeneID:9496,Genbank:NM_001321120.1,HGNC:HGNC:11603,MIM:601719 T-box 4 GO:0001525,GO:0002009,GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0007275,GO:0030324,GO:0030326,GO:0035108,GO:0048705 angiogenesis|morphogenesis of an epithelium|DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|lung development|embryonic limb morphogenesis|limb morphogenesis|skeletal system morphogenesis TBX6 6.56485913391369 9.253521707397 3.87619656043037 0.418888795314745 -1.25536080022708 0.298595675423285 1 0.182797 0.154498 0.0415648 0.078108 GeneID:6911,Genbank:XM_011545926.3,HGNC:HGNC:11605,MIM:602427 T-box 6 GO:0000122,GO:0000980,GO:0001085,GO:0001102,GO:0001191,GO:0001707,GO:0001708,GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0007498,GO:0009653,GO:0010977,GO:0014043,GO:0023019,GO:0032525,GO:0045944 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|transcriptional repressor activity, RNA polymerase II transcription factor binding|mesoderm formation|cell fate specification|DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|mesoderm development|anatomical structure morphogenesis|negative regulation of neuron projection development|negative regulation of neuron maturation|signal transduction involved in regulation of gene expression|somite rostral/caudal axis specification|positive regulation of transcription from RNA polymerase II promoter TBXA2R 92.9521449765229 90.4406612971936 95.4636286558522 1.05553881723789 0.077979634494513 0.830370790805446 1 0.995459 1.09274 1.02383 1.14521 GeneID:6915,Genbank:NM_201636.2,HGNC:HGNC:11608,MIM:188070 thromboxane A2 receptor hsa04020,hsa04080,hsa04611 Calcium signaling pathway|Neuroactive ligand-receptor interaction|Platelet activation TBXAS1 98.4760994356761 95.6677505844539 101.284448286898 1.05871046061113 0.0823080906007659 0.788705985787274 1 0.185107 0.194054 0.229893 0.208822 GeneID:6916,Genbank:NM_001130966.2,HGNC:HGNC:11609,MIM:274180 thromboxane A synthase 1 hsa00590,hsa04611 Arachidonic acid metabolism|Platelet activation TC2N 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00838138 0 GeneID:123036,Genbank:NM_001128596.2,HGNC:HGNC:19859 tandem C2 domains, nuclear GO:0005634,GO:0005886 nucleus|plasma membrane TCAF1 462.737678057588 503.370612041672 422.104744073503 0.838556590265462 -0.2540199470662 0.156446110643625 1 2.50294 2.36067 2.15087 2.03627 GeneID:9747,Genbank:NM_001206938.1,HGNC:HGNC:22201,MIM:616251 TRPM8 channel associated factor 1 GO:0005886,GO:0030336,GO:0044325,GO:0090314,GO:1901529 plasma membrane|negative regulation of cell migration|ion channel binding|positive regulation of protein targeting to membrane|positive regulation of anion channel activity TCAF2 13.429269626843 10.8678147373239 15.9907245163621 1.47138361325247 0.55717342931589 0.488117747105974 1 0.0780584 0.0477348 0.0739097 0.0863306 GeneID:285966,Genbank:NM_001130025.1,HGNC:HGNC:26878,MIM:616252 TRPM8 channel associated factor 2 GO:0005886,GO:0010360,GO:0030054,GO:0030335,GO:0044325,GO:0090314 plasma membrane|negative regulation of anion channel activity|cell junction|positive regulation of cell migration|ion channel binding|positive regulation of protein targeting to membrane TCAIM 549.07225844539 600.421315936881 497.723200953898 0.828956580559209 -0.270631557282618 0.122691138569558 1 4.30124 3.89907 3.41804 3.26695 GeneID:285343,Genbank:NM_001282913.1,HGNC:HGNC:25241 T cell activation inhibitor, mitochondrial GO:0005739 mitochondrion TCAP 8.12828481372415 6.56303332418548 9.69353630326283 1.47699026112531 0.562660313392791 0.638084116719983 1 0.112185 0.340376 0.309932 0.288661 GeneID:8557,Genbank:NM_003673.3,HGNC:HGNC:11610,MIM:604488 titin-cap GO:0001756,GO:0003009,GO:0003300,GO:0005829,GO:0006461,GO:0007512,GO:0008307,GO:0014898,GO:0030018,GO:0030049,GO:0030240,GO:0030241,GO:0030674,GO:0030916,GO:0031432,GO:0031674,GO:0035994,GO:0035995,GO:0036122,GO:0044325,GO:0045214,GO:0048739,GO:0048769,GO:0050982,GO:0051373,GO:0055003,GO:0055008,GO:0060048,GO:0070080 somitogenesis|skeletal muscle contraction|cardiac muscle hypertrophy|cytosol|protein complex assembly|adult heart development|structural constituent of muscle|cardiac muscle hypertrophy in response to stress|Z disc|muscle filament sliding|skeletal muscle thin filament assembly|skeletal muscle myosin thick filament assembly|protein binding, bridging|otic vesicle formation|titin binding|I band|response to muscle stretch|detection of muscle stretch|BMP binding|ion channel binding|sarcomere organization|cardiac muscle fiber development|sarcomerogenesis|detection of mechanical stimulus|FATZ binding|cardiac myofibril assembly|cardiac muscle tissue morphogenesis|cardiac muscle contraction|titin Z domain binding TCEA1 2048.52676273942 2122.6104153206 1974.44311015824 0.930195713686831 -0.104393802903789 0.482406494543112 1 28.7666 25.2141 28.2553 24.6034 GeneID:6917,Genbank:NM_201437.2,HGNC:HGNC:11612,MIM:601425 transcription elongation factor A1 GO:0003677,GO:0005634,GO:0005654,GO:0005669,GO:0005730,GO:0006283,GO:0006355,GO:0006366,GO:0006368,GO:0008270,GO:1901919 DNA binding|nucleus|nucleoplasm|transcription factor TFIID complex|nucleolus|transcription-coupled nucleotide-excision repair|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|zinc ion binding|positive regulation of exoribonuclease activity TCEA2 431.115312061452 443.545717385006 418.684906737898 0.943949834994058 -0.0832179034446788 0.676999987625974 1 1.3357 1.60665 1.28171 1.56496 GeneID:6919,Genbank:XM_011529022.1,HGNC:HGNC:11614,MIM:604784 transcription elongation factor A2 GO:0003677,GO:0006354,GO:0008023,GO:0008270,GO:0032784,GO:0045944 DNA binding|DNA-templated transcription, elongation|transcription elongation factor complex|zinc ion binding|regulation of DNA-templated transcription, elongation|positive regulation of transcription from RNA polymerase II promoter TCEA3 17.3250660995811 18.1708594919994 16.4792727071628 0.906906616850932 -0.140974089163315 0.848789009121344 1 0.0558462 0.115272 0.158747 0.0614527 GeneID:6920,Genbank:NM_003196.2,HGNC:HGNC:11615,MIM:604128 transcription elongation factor A3 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding TCEAL1 608.223887014687 614.077705608496 602.370068420877 0.980934599838602 -0.027771141555746 0.850509184419544 1 15.9477 18.0924 16.6801 15.8307 GeneID:9338,Genbank:NM_001006640.1,HGNC:HGNC:11616,MIM:300237 transcription elongation factor A like 1 GO:0005634,GO:0006351,GO:0006355 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated TCEAL2 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.0465219 0.0221332 0 0 GeneID:140597,Genbank:NM_080390.3,HGNC:HGNC:29818 transcription elongation factor A like 2 GO:0005634,GO:0006351,GO:0006357,GO:0050699 nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|WW domain binding TCEAL3 1537.13258437448 1550.16342091657 1524.10174783238 0.983187789924252 -0.0244610956994801 0.865233311033516 1 37.3022 37.269 36.4439 37.5099 GeneID:85012,Genbank:NM_001006933.1,HGNC:HGNC:28247 transcription elongation factor A like 3 GO:0005634,GO:0006351,GO:0006357,GO:0050699 nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|WW domain binding TCEAL4 1714.14248216614 1657.48702394353 1770.79794038876 1.06836307905183 0.095402024674945 0.506156031880912 1 17.7174 17.8478 19.0837 19.4646 GeneID:79921,Genbank:NM_001300901.1,HGNC:HGNC:26121 transcription elongation factor A like 4 GO:0005634,GO:0006351,GO:0006355 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated TCEAL5 1.26820168020816 1.56626675524197 0.97013660517434 0.619394239153384 -0.691070129994731 0.974558099637673 1 0.0463011 0.0216094 0.0440546 0 GeneID:340543,Genbank:NM_001012979.2,HGNC:HGNC:22282 transcription elongation factor A like 5 GO:0005634,GO:0006351,GO:0006357,GO:0050699 nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|WW domain binding TCEAL6 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0.025015 0 0.047328 0.0220026 GeneID:158931,Genbank:NM_001006938.2,HGNC:HGNC:24553 transcription elongation factor A like 6 GO:0005634,GO:0006351,GO:0006357,GO:0050699 nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|WW domain binding TCEAL8 1294.69027505468 1285.30841779981 1304.07213230956 1.01459860859067 0.0209090870869914 0.887302637897143 1 39.276 41.4501 40.1775 42.5936 GeneID:90843,Genbank:NM_001006684.1,HGNC:HGNC:28683 transcription elongation factor A like 8 GO:0005634,GO:0006351,GO:0006357,GO:0050699 nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|WW domain binding TCEAL9 891.291197635642 885.108480849403 897.473914421882 1.01397052885609 0.0200157208905116 0.890300458508469 1 27.3042 23.4874 24.0728 25.9472 GeneID:51186,Genbank:NM_016303.2,HGNC:HGNC:30084 transcription elongation factor A like 9 GO:0005634,GO:0006351,GO:0006357,GO:0050699 nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|WW domain binding TCEANC 15.5320024810956 14.5864721991351 16.477532763056 1.12964482008426 0.175869235604264 0.825624161263827 1 0.186486 0.117579 0.190595 0.177513 GeneID:170082,Genbank:NM_001297563.1,HGNC:HGNC:28277 transcription elongation factor A N-terminal and central domain containing GO:0005634,GO:0006351 nucleus|transcription, DNA-templated TCEANC2 211.681642140146 202.367012040502 220.996272239789 1.09205680318864 0.127047899799178 0.58227624282745 1 1.01989 1.10975 1.23857 1.07029 GeneID:127428,Genbank:XM_017000293.1,HGNC:HGNC:26494 transcription elongation factor A N-terminal and central domain containing 2 GO:0005634,GO:0006351 nucleus|transcription, DNA-templated TCERG1 1144.51804751329 1237.30002071735 1051.73607430924 0.850025100379033 -0.234422651686793 0.156001943247915 1 6.2825 5.63154 6.03586 4.58574 GeneID:10915,Genbank:NM_006706.3,HGNC:HGNC:15630,MIM:605409 transcription elongation regulator 1 GO:0000122,GO:0001103,GO:0001106,GO:0003713,GO:0003723,GO:0005634,GO:0005654,GO:0006366,GO:0042802,GO:0070064 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II repressing transcription factor binding|RNA polymerase II transcription corepressor activity|transcription coactivator activity|RNA binding|nucleus|nucleoplasm|transcription from RNA polymerase II promoter|identical protein binding|proline-rich region binding hsa03040 Spliceosome TCERG1L 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0317956 0.0165661 0 GeneID:256536,Genbank:NM_174937.3,HGNC:HGNC:23533 transcription elongation regulator 1 like TCF12 1684.59694956259 1672.26255023884 1696.93134888633 1.01475174974407 0.0211268276876496 0.917225455310614 1 7.01209 5.95879 8.0643 5.46887 GeneID:6938,Genbank:NM_001322151.1,HGNC:HGNC:11623,MIM:600480 transcription factor 12 GO:0000790,GO:0000978,GO:0001077,GO:0003677,GO:0003700,GO:0005634,GO:0005667,GO:0005737,GO:0008134,GO:0010628,GO:0016607,GO:0035497,GO:0042803,GO:0043425,GO:0045666,GO:0045893,GO:0045944,GO:0046332,GO:0046982,GO:0070888,GO:0071837,GO:0090575 nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|transcription factor complex|cytoplasm|transcription factor binding|positive regulation of gene expression|nuclear speck|cAMP response element binding|protein homodimerization activity|bHLH transcription factor binding|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|SMAD binding|protein heterodimerization activity|E-box binding|HMG box domain binding|RNA polymerase II transcription factor complex TCF19 3244.34429625124 2992.97584684258 3495.71274565991 1.16797225388494 0.224006002250412 0.102456497032861 1 33.3291 34.6448 42.441 37.9433 GeneID:6941,Genbank:NM_001318908.1,HGNC:HGNC:11629,MIM:600912 transcription factor 19 GO:0003700,GO:0005634,GO:0006351,GO:0006357,GO:0008283,GO:0046872 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|cell proliferation|metal ion binding TCF20 1234.31548098907 1263.8325370088 1204.79842496933 0.953289608938864 -0.06901352408152 0.639731618544934 1 4.62787 4.85297 4.74524 4.42529 GeneID:6942,Genbank:NM_005650.3,HGNC:HGNC:11631,MIM:603107 transcription factor 20 GO:0003677,GO:0003700,GO:0003713,GO:0003723,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0016604,GO:0044212,GO:0045944,GO:0046872 DNA binding|DNA binding transcription factor activity|transcription coactivator activity|RNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear body|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding TCF21 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0109726 0 GeneID:6943,Genbank:NM_198392.2,HGNC:HGNC:11632,MIM:603306 transcription factor 21 GO:0000122,GO:0001077,GO:0001078,GO:0001657,GO:0001658,GO:0001763,GO:0001822,GO:0001944,GO:0005634,GO:0007530,GO:0014707,GO:0030855,GO:0032835,GO:0042826,GO:0043425,GO:0045944,GO:0046983,GO:0048286,GO:0048536,GO:0048557,GO:0048608,GO:0048732,GO:0050681,GO:0060008,GO:0060021,GO:0060425,GO:0060426,GO:0060435,GO:0060539,GO:0060541,GO:0060766,GO:0070888,GO:0072162,GO:0072277 negative regulation of transcription from RNA polymerase II promoter|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|ureteric bud development|branching involved in ureteric bud morphogenesis|morphogenesis of a branching structure|kidney development|vasculature development|nucleus|sex determination|branchiomeric skeletal muscle development|epithelial cell differentiation|glomerulus development|histone deacetylase binding|bHLH transcription factor binding|positive regulation of transcription from RNA polymerase II promoter|protein dimerization activity|lung alveolus development|spleen development|embryonic digestive tract morphogenesis|reproductive structure development|gland development|androgen receptor binding|Sertoli cell differentiation|palate development|lung morphogenesis|lung vasculature development|bronchiole development|diaphragm development|respiratory system development|negative regulation of androgen receptor signaling pathway|E-box binding|metanephric mesenchymal cell differentiation|metanephric glomerular capillary formation TCF25 2703.26775468975 2660.75277294105 2745.78273643845 1.03195710791402 0.0453830080812144 0.762103645738021 1 23.5098 25.7511 25.5979 26.6583 GeneID:22980,Genbank:NM_014972.2,HGNC:HGNC:29181,MIM:612326 transcription factor 25 GO:0000122,GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0007507 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|heart development TCF3 2754.08227450205 2253.39590406173 3254.76864494236 1.44438384709747 0.530454191473213 0.000130022020494609 0.0274020832356607 10.104 10.7803 15.441 14.7327 GeneID:6929,Genbank:NM_001351778.1,HGNC:HGNC:11633,MIM:147141 transcription factor 3 hsa04550,hsa05166,hsa05202 Signaling pathways regulating pluripotency of stem cells|Human T-cell leukemia virus 1 infection|Transcriptional misregulation in cancer TCF4 223.937643481714 240.427868258051 207.447418705377 0.862826011844532 -0.212858424423494 0.440346402583783 1 0.793605 0.616778 0.674007 0.498683 GeneID:6925,Genbank:NM_001243226.2,HGNC:HGNC:11634,MIM:602272 transcription factor 4 GO:0000790,GO:0000978,GO:0001011,GO:0001077,GO:0001087,GO:0001093,GO:0003677,GO:0003700,GO:0005634,GO:0005667,GO:0006352,GO:0006367,GO:0008022,GO:0042802,GO:0042803,GO:0043425,GO:0045666,GO:0045893,GO:0045944,GO:0046982,GO:0065004,GO:0070369,GO:0070888,GO:1990907 nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcription factor activity, TFIIB-class binding|TFIIB-class transcription factor binding|DNA binding|DNA binding transcription factor activity|nucleus|transcription factor complex|DNA-templated transcription, initiation|transcription initiation from RNA polymerase II promoter|protein C-terminus binding|identical protein binding|protein homodimerization activity|bHLH transcription factor binding|positive regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|protein-DNA complex assembly|beta-catenin-TCF7L2 complex|E-box binding|beta-catenin-TCF complex TCF7 113.115051033293 113.800392456876 112.429709609709 0.987955376799893 -0.0174822141334425 0.946388570780158 1 0.230539 0.281302 0.261733 0.268744 GeneID:6932,Genbank:NM_001346425.1,HGNC:HGNC:11639,MIM:189908 transcription factor 7 GO:0001047,GO:0001227,GO:0005634,GO:0005654,GO:0005667,GO:0005719,GO:0006351,GO:0006357,GO:0006955,GO:0008013,GO:0016604,GO:0021915,GO:0030538,GO:0033153,GO:0042127,GO:0043565,GO:0044212,GO:0044336,GO:0046632,GO:0048557,GO:0048619,GO:0060070,GO:0071353,GO:1904837 core promoter binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|nucleoplasm|transcription factor complex|nuclear euchromatin|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|immune response|beta-catenin binding|nuclear body|neural tube development|embryonic genitalia morphogenesis|T cell receptor V(D)J recombination|regulation of cell proliferation|sequence-specific DNA binding|transcription regulatory region DNA binding|canonical Wnt signaling pathway involved in negative regulation of apoptotic process|alpha-beta T cell differentiation|embryonic digestive tract morphogenesis|embryonic hindgut morphogenesis|canonical Wnt signaling pathway|cellular response to interleukin-4|beta-catenin-TCF complex assembly hsa04310,hsa04390,hsa04520,hsa04916,hsa04934,hsa05165,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412 Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy (ARVC) TCF7L1 141.548534887104 108.159667006813 174.937402767396 1.61739960568089 0.693676164841352 0.00760577131022418 0.342174250855479 1.36292 1.27951 2.07916 2.55545 GeneID:83439,Genbank:NM_031283.2,HGNC:HGNC:11640,MIM:604652 transcription factor 7 like 1 GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006325,GO:0006351,GO:0006355,GO:0006357,GO:0008013,GO:0030111,GO:0043565,GO:0044212,GO:0060070,GO:1904837 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|cytosol|chromatin organization|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|beta-catenin binding|regulation of Wnt signaling pathway|sequence-specific DNA binding|transcription regulatory region DNA binding|canonical Wnt signaling pathway|beta-catenin-TCF complex assembly hsa04310,hsa04390,hsa04520,hsa04916,hsa04934,hsa05165,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412 Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy (ARVC) TCF7L2 789.082512971873 803.279416380196 774.885609563551 0.964652639868956 -0.0519185566040638 0.747156490028218 1 5.51844 5.53574 5.13035 5.60976 GeneID:6934,Genbank:XM_017016589.2,HGNC:HGNC:11641,MIM:602228 transcription factor 7 like 2 GO:0000122,GO:0000790,GO:0000978,GO:0001103,GO:0001568,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0007050,GO:0007223,GO:0008013,GO:0008134,GO:0008283,GO:0009749,GO:0010909,GO:0016605,GO:0019901,GO:0031016,GO:0032024,GO:0032092,GO:0032350,GO:0032993,GO:0035257,GO:0042593,GO:0043433,GO:0043565,GO:0043570,GO:0044212,GO:0044334,GO:0045295,GO:0045444,GO:0045892,GO:0045944,GO:0046827,GO:0048625,GO:0048660,GO:0051897,GO:0060070,GO:0070016,GO:0070369,GO:0090090,GO:1904837,GO:2000675,GO:2001237 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II repressing transcription factor binding|blood vessel development|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|cell cycle arrest|Wnt signaling pathway, calcium modulating pathway|beta-catenin binding|transcription factor binding|cell proliferation|response to glucose|positive regulation of heparan sulfate proteoglycan biosynthetic process|PML body|protein kinase binding|pancreas development|positive regulation of insulin secretion|positive regulation of protein binding|regulation of hormone metabolic process|protein-DNA complex|nuclear hormone receptor binding|glucose homeostasis|negative regulation of DNA binding transcription factor activity|sequence-specific DNA binding|maintenance of DNA repeat elements|transcription regulatory region DNA binding|canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition|gamma-catenin binding|fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|positive regulation of protein export from nucleus|myoblast fate commitment|regulation of smooth muscle cell proliferation|positive regulation of protein kinase B signaling|canonical Wnt signaling pathway|armadillo repeat domain binding|beta-catenin-TCF7L2 complex|negative regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly|negative regulation of type B pancreatic cell apoptotic process|negative regulation of extrinsic apoptotic signaling pathway hsa04310,hsa04390,hsa04520,hsa04916,hsa04934,hsa05165,hsa05200,hsa05210,hsa05213,hsa05215,hsa05216,hsa05217,hsa05221,hsa05224,hsa05225,hsa05226,hsa05412 Wnt signaling pathway|Hippo signaling pathway|Adherens junction|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Pathways in cancer|Colorectal cancer|Endometrial cancer|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Acute myeloid leukemia|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Arrhythmogenic right ventricular cardiomyopathy (ARVC) TCFL5 806.371768166485 800.070447630558 812.673088702413 1.01575191423353 0.0225480834000246 0.901107454676664 1 6.13273 6.61367 6.31515 6.75019 GeneID:10732,Genbank:NM_006602.3,HGNC:HGNC:11646,MIM:604745 transcription factor like 5 GO:0000122,GO:0000978,GO:0001078,GO:0001673,GO:0003677,GO:0003700,GO:0005634,GO:0006355,GO:0006366,GO:0007275,GO:0007283,GO:0030154,GO:0042127,GO:0045595,GO:0046983 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|male germ cell nucleus|DNA binding|DNA binding transcription factor activity|nucleus|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|multicellular organism development|spermatogenesis|cell differentiation|regulation of cell proliferation|regulation of cell differentiation|protein dimerization activity TCHH 4.06604086341523 4.25675513845349 3.87532658837698 0.910394528773602 -0.135436207426205 1 1 0.0407623 0.00525955 0.0108625 0.0303257 GeneID:7062,Genbank:NM_007113.3,HGNC:HGNC:11791,MIM:190370 trichohyalin GO:0001533,GO:0005509,GO:0005829,GO:0005856,GO:0046914,GO:0070268 cornified envelope|calcium ion binding|cytosol|cytoskeleton|transition metal ion binding|cornification TCHP 424.757611145919 462.791755229436 386.723467062402 0.835631712735846 -0.259060850282039 0.154494876692282 1 3.54051 3.65191 3.02646 3.14308 GeneID:84260,Genbank:XM_011538837.2,HGNC:HGNC:28135,MIM:612654 trichoplein keratin filament binding GO:0005737,GO:0005739,GO:0005813,GO:0005829,GO:0005886,GO:0006915,GO:0030030,GO:0030057,GO:0030308,GO:0045095,GO:0045179,GO:0097539,GO:1902018 cytoplasm|mitochondrion|centrosome|cytosol|plasma membrane|apoptotic process|cell projection organization|desmosome|negative regulation of cell growth|keratin filament|apical cortex|ciliary transition fiber|negative regulation of cilium assembly TCIM 103.189061528313 111.388253066667 94.9898699899592 0.852781755479254 -0.229751521660305 0.442994088181327 1 2.38053 2.46219 2.20285 1.91933 GeneID:56892,Genbank:NM_020130.4,HGNC:HGNC:1357,MIM:607702 transcriptional and immune response regulator GO:0002264,GO:0005112,GO:0005622,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006915,GO:0010739,GO:0016607,GO:0034605,GO:0042346,GO:0043066,GO:0043620,GO:0045746,GO:1900020,GO:1902806,GO:1903706 endothelial cell activation involved in immune response|Notch binding|intracellular|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|plasma membrane|apoptotic process|positive regulation of protein kinase A signaling|nuclear speck|cellular response to heat|positive regulation of NF-kappaB import into nucleus|negative regulation of apoptotic process|regulation of DNA-templated transcription in response to stress|negative regulation of Notch signaling pathway|positive regulation of protein kinase C activity|regulation of cell cycle G1/S phase transition|regulation of hemopoiesis TCIRG1 800.70391019734 795.496108878671 805.911711516008 1.0130932163226 0.0187669249180972 0.910565148425338 1 5.74251 5.27715 5.87797 5.91311 GeneID:10312,Genbank:NM_001351059.1,HGNC:HGNC:11647,MIM:604592 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 hsa00190,hsa04142,hsa04145,hsa04721,hsa04966,hsa05110,hsa05120,hsa05152,hsa05165,hsa05323 Oxidative phosphorylation|Lysosome|Phagosome|Synaptic vesicle cycle|Collecting duct acid secretion|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Tuberculosis|Human papillomavirus infection|Rheumatoid arthritis TCL1B 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0449297 GeneID:9623,Genbank:NM_004918.3,HGNC:HGNC:11649,MIM:603769 T cell leukemia/lymphoma 1B hsa04151 PI3K-Akt signaling pathway TCN1 26.0618564243433 25.464095591567 26.6596172571196 1.04694930794827 0.0661915903660223 0.958642508132971 1 0.502961 0.576431 0.633202 0.376611 GeneID:6947,Genbank:NM_001062.3,HGNC:HGNC:11652,MIM:189905 transcobalamin 1 GO:0005576,GO:0005615,GO:0006824,GO:0009235,GO:0015889,GO:0031419,GO:0035580,GO:0043312,GO:1904724 extracellular region|extracellular space|cobalt ion transport|cobalamin metabolic process|cobalamin transport|cobalamin binding|specific granule lumen|neutrophil degranulation|tertiary granule lumen TCN2 744.46531339894 657.837122205902 831.093504591978 1.2633727658985 0.337280377974726 0.0371967931783477 0.744556882325193 11.2685 11.7243 14.1768 15.3327 GeneID:6948,Genbank:NM_000355.3,HGNC:HGNC:11653,MIM:613441 transcobalamin 2 hsa04977 Vitamin digestion and absorption TCOF1 2802.15556017031 2703.24388908643 2901.06723125419 1.07317998311821 0.101892050909912 0.472678003161849 1 10.912 11.7941 13.0468 11.6952 GeneID:6949,Genbank:NM_001135243.1,HGNC:HGNC:11654,MIM:606847 treacle ribosome biogenesis factor 1 GO:0001042,GO:0001501,GO:0001650,GO:0003723,GO:0005215,GO:0005634,GO:0005730,GO:0005829,GO:0006417,GO:0014029,GO:0014032,GO:0046982,GO:0097110 RNA polymerase I core binding|skeletal system development|fibrillar center|RNA binding|transporter activity|nucleus|nucleolus|cytosol|regulation of translation|neural crest formation|neural crest cell development|protein heterodimerization activity|scaffold protein binding hsa03008 Ribosome biogenesis in eukaryotes TCP1 8103.92132907092 8850.67865269065 7357.16400545118 0.831254222885447 -0.266638330278904 0.0417320853943506 0.762992100086665 136.666 140.865 120.415 112.806 GeneID:6950,Genbank:NM_001008897.1,HGNC:HGNC:11655,MIM:186980 t-complex 1 GO:0000242,GO:0001669,GO:0002199,GO:0003723,GO:0005524,GO:0005720,GO:0005794,GO:0005813,GO:0005829,GO:0005832,GO:0005874,GO:0006457,GO:0006458,GO:0007021,GO:0007339,GO:0031625,GO:0032212,GO:0035722,GO:0043209,GO:0044053,GO:0044183,GO:0044297,GO:0050821,GO:0051082,GO:0051973,GO:0061077,GO:0070062,GO:0090666,GO:1901998,GO:1904851,GO:1904871,GO:1904874,GO:2000109 pericentriolar material|acrosomal vesicle|zona pellucida receptor complex|RNA binding|ATP binding|nuclear heterochromatin|Golgi apparatus|centrosome|cytosol|chaperonin-containing T-complex|microtubule|protein folding|'de novo' protein folding|tubulin complex assembly|binding of sperm to zona pellucida|ubiquitin protein ligase binding|positive regulation of telomere maintenance via telomerase|interleukin-12-mediated signaling pathway|myelin sheath|translocation of peptides or proteins into host cell cytoplasm|protein binding involved in protein folding|cell body|protein stabilization|unfolded protein binding|positive regulation of telomerase activity|chaperone-mediated protein folding|extracellular exosome|scaRNA localization to Cajal body|toxin transport|positive regulation of establishment of protein localization to telomere|positive regulation of protein localization to Cajal body|positive regulation of telomerase RNA localization to Cajal body|regulation of macrophage apoptotic process TCP10 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:6953,Genbank:XM_017011231.1,HGNC:HGNC:11656,MIM:187020 t-complex 10 GO:0005829 cytosol TCP11 8.01625753391 8.76345030543964 7.26906476238037 0.829475207712233 -0.269729233953531 0.856933001880866 1 0.115682 0.0704093 0.0727428 0.0678508 GeneID:6954,Genbank:NM_001261819.1,HGNC:HGNC:11658,MIM:186982 t-complex 11 GO:0001669,GO:0007275,GO:0007283,GO:0010737,GO:0016021,GO:0030154,GO:0036126,GO:0043949,GO:0097225,GO:1902490 acrosomal vesicle|multicellular organism development|spermatogenesis|protein kinase A signaling|integral component of membrane|cell differentiation|sperm flagellum|regulation of cAMP-mediated signaling|sperm midpiece|regulation of sperm capacitation TCP11L1 957.163682849284 963.500287852365 950.827077846203 0.986846698266785 -0.0191021083090611 0.918260197259342 1 3.81944 3.57068 3.75366 3.67033 GeneID:55346,Genbank:NM_018393.3,HGNC:HGNC:25655 t-complex 11 like 1 GO:0005874 microtubule TCP11L2 77.0350449279863 82.3495788373432 71.7205110186294 0.870927478090588 -0.19937550391061 0.570894983492532 1 0.582165 0.47811 0.432914 0.453326 GeneID:255394,Genbank:XM_017019131.1,HGNC:HGNC:28627 t-complex 11 like 2 TCTA 976.643765889061 807.690058997812 1145.59747278031 1.41836272468399 0.504226527065403 0.00102395390163406 0.103795225877033 16.8601 16.9069 23.3831 25.4546 GeneID:6988,Genbank:NM_022171.2,HGNC:HGNC:11692,MIM:600690 T cell leukemia translocation altered TCTE1 13.4523269265106 14.7883859529828 12.1162679000385 0.819309689276445 -0.287519218439158 0.741705992637147 1 0.127592 0.122992 0.154059 0.121842 GeneID:202500,Genbank:NM_182539.3,HGNC:HGNC:11693,MIM:186975 t-complex-associated-testis-expressed 1 TCTE3 2.70309159191729 2.49838328447175 2.90779989936283 1.16387262012027 0.21893317132456 1 1 0 0.095846 0 0.0906034 GeneID:6991,Genbank:XM_006715554.3,HGNC:HGNC:11695,MIM:186977 t-complex-associated-testis-expressed 3 GO:0003774,GO:0005737,GO:0005874,GO:0016020,GO:0030286 motor activity|cytoplasm|microtubule|membrane|dynein complex TCTEX1D2 308.49858189166 304.443908469979 312.553255313342 1.02663658762009 0.0379255818285329 0.850870808034512 1 21.6353 19.6978 18.5284 21.4779 GeneID:255758,Genbank:NM_001351628.1,HGNC:HGNC:28482,MIM:617353 Tctex1 domain containing 2 GO:0005868,GO:0045505,GO:0060271,GO:1902017,GO:1905799 cytoplasmic dynein complex|dynein intermediate chain binding|cilium assembly|regulation of cilium assembly|regulation of intraciliary retrograde transport TCTEX1D4 8.22847049041083 7.73528122683997 8.72165975398169 1.12751682818191 0.173148965856192 0.92167520364934 1 0.195903 0.295551 0.315715 0.253348 GeneID:343521,Genbank:NM_001013632.3,HGNC:HGNC:32315,MIM:611713 Tctex1 domain containing 4 GO:0001669,GO:0005634,GO:0005815,GO:0005930,GO:0008157,GO:0036126 acrosomal vesicle|nucleus|microtubule organizing center|axoneme|protein phosphatase 1 binding|sperm flagellum TCTN1 290.09392337595 276.327542114778 303.860304637122 1.09963814070661 0.137028852390933 0.487345897798095 1 1.24094 1.2441 1.41689 1.36919 GeneID:79600,Genbank:NM_001173975.2,HGNC:HGNC:26113,MIM:609863 tectonic family member 1 GO:0001701,GO:0001841,GO:0005615,GO:0005829,GO:0005856,GO:0008589,GO:0016020,GO:0021523,GO:0021537,GO:0021904,GO:0021956,GO:0036038,GO:0060271,GO:0097711,GO:1904491 in utero embryonic development|neural tube formation|extracellular space|cytosol|cytoskeleton|regulation of smoothened signaling pathway|membrane|somatic motor neuron differentiation|telencephalon development|dorsal/ventral neural tube patterning|central nervous system interneuron axonogenesis|MKS complex|cilium assembly|ciliary basal body-plasma membrane docking|protein localization to ciliary transition zone TCTN2 188.94848118138 186.944475861507 190.952486501253 1.02143957782799 0.0306038655042137 0.91530443412812 1 2.58968 2.80526 2.89697 2.58781 GeneID:79867,Genbank:XM_017019975.1,HGNC:HGNC:25774,MIM:613846 tectonic family member 2 GO:0005737,GO:0005856,GO:0007224,GO:0016021,GO:0036038,GO:0060170,GO:0060271,GO:0097711 cytoplasm|cytoskeleton|smoothened signaling pathway|integral component of membrane|MKS complex|ciliary membrane|cilium assembly|ciliary basal body-plasma membrane docking TCTN3 1664.49256670134 1697.33567798038 1631.6494554223 0.961300393663886 -0.0569407703087905 0.692456102247626 1 22.8095 22.7368 21.2984 22.6295 GeneID:26123,Genbank:NM_001143973.1,HGNC:HGNC:24519,MIM:613847 tectonic family member 3 GO:0005634,GO:0006915,GO:0007224,GO:0016021,GO:0043065,GO:0060170,GO:0060271,GO:0070062,GO:0097711 nucleus|apoptotic process|smoothened signaling pathway|integral component of membrane|positive regulation of apoptotic process|ciliary membrane|cilium assembly|extracellular exosome|ciliary basal body-plasma membrane docking TDG 611.112765769544 611.106834230573 611.118697308514 1.00001941244522 2.80059666136645e-05 0.979706231926781 1 7.98529 7.23547 8.00127 7.47526 GeneID:6996,Genbank:NM_003211.4,HGNC:HGNC:11700,MIM:601423 thymine DNA glycosylase hsa03410 Base excision repair TDGF1 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.0216472 0.0220162 0.0205004 GeneID:6997,Genbank:NM_001174136.1,HGNC:HGNC:11701,MIM:187395 teratocarcinoma-derived growth factor 1 GO:0000187,GO:0001763,GO:0002042,GO:0005102,GO:0005615,GO:0005886,GO:0007507,GO:0008083,GO:0008284,GO:0008595,GO:0009790,GO:0009966,GO:0009986,GO:0010595,GO:0016324,GO:0018105,GO:0019897,GO:0030154,GO:0030335,GO:0030879,GO:0031225,GO:0035019,GO:0035729,GO:0043066,GO:0044344,GO:0045121,GO:0050731,GO:0071346,GO:0071354,GO:0071356,GO:0071364 activation of MAPK activity|morphogenesis of a branching structure|cell migration involved in sprouting angiogenesis|receptor binding|extracellular space|plasma membrane|heart development|growth factor activity|positive regulation of cell proliferation|anterior/posterior axis specification, embryo|embryo development|regulation of signal transduction|cell surface|positive regulation of endothelial cell migration|apical plasma membrane|peptidyl-serine phosphorylation|extrinsic component of plasma membrane|cell differentiation|positive regulation of cell migration|mammary gland development|anchored component of membrane|somatic stem cell population maintenance|cellular response to hepatocyte growth factor stimulus|negative regulation of apoptotic process|cellular response to fibroblast growth factor stimulus|membrane raft|positive regulation of peptidyl-tyrosine phosphorylation|cellular response to interferon-gamma|cellular response to interleukin-6|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus TDO2 2.49251021304816 4.01662376502878 0.968396661067546 0.241097179551395 -2.05231332105607 0.369121355190859 1 0.0237124 0.0691397 0 0.021327 GeneID:6999,Genbank:NM_005651.3,HGNC:HGNC:11708,MIM:191070 tryptophan 2,3-dioxygenase GO:0004833,GO:0005829,GO:0006569,GO:0016597,GO:0019441,GO:0019442,GO:0019825,GO:0020037,GO:0042802,GO:0046872,GO:0051289 tryptophan 2,3-dioxygenase activity|cytosol|tryptophan catabolic process|amino acid binding|tryptophan catabolic process to kynurenine|tryptophan catabolic process to acetyl-CoA|oxygen binding|heme binding|identical protein binding|metal ion binding|protein homotetramerization hsa00380 Tryptophan metabolism TDP1 760.950179959196 799.848916566494 722.051443351899 0.902734789529307 -0.147625887944418 0.357920800051753 1 5.08195 5.1157 4.60177 5.04392 GeneID:55775,Genbank:XM_011536942.3,HGNC:HGNC:18884,MIM:607198 tyrosyl-DNA phosphodiesterase 1 TDP2 916.470879534383 1004.18398886822 828.757770200542 0.825304704504004 -0.277001230659845 0.0954883616716717 1 21.0842 18.4167 17.9988 15.0001 GeneID:51567,Genbank:NM_016614.2,HGNC:HGNC:17768,MIM:605764 tyrosyl-DNA phosphodiesterase 2 TDRD12 4.82603107574715 5.77499561901052 3.87706653248377 0.671354021416221 -0.57485435938036 0.756734608777744 1 0.0371889 0.0173853 0.0177547 0.0220244 GeneID:91646,Genbank:NM_001110822.1,HGNC:HGNC:25044 tudor domain containing 12 GO:0003676,GO:0004386,GO:0005524,GO:0007140,GO:0007275,GO:0007283,GO:0009566,GO:0030154,GO:0031047,GO:0034587,GO:0043046,GO:1903955,GO:1990923 nucleic acid binding|helicase activity|ATP binding|male meiotic nuclear division|multicellular organism development|spermatogenesis|fertilization|cell differentiation|gene silencing by RNA|piRNA metabolic process|DNA methylation involved in gamete generation|positive regulation of protein targeting to mitochondrion|PET complex TDRD3 109.47328298598 103.595136910034 115.351429061926 1.11348305048433 0.155079597489589 0.582407922761822 1 0.898852 0.78004 1.00671 0.862936 GeneID:81550,Genbank:NM_001146071.1,HGNC:HGNC:20612,MIM:614392 tudor domain containing 3 GO:0003682,GO:0003713,GO:0005634,GO:0005737,GO:0016569,GO:0035064 chromatin binding|transcription coactivator activity|nucleus|cytoplasm|covalent chromatin modification|methylated histone binding TDRD5 1.21517230615302 0.490071401957362 1.94027321034868 3.95916432299286 1.98519594689495 0.683429885754535 1 0 0.00865022 0.0176328 0 GeneID:163589,Genbank:NM_001199085.2,HGNC:HGNC:20614,MIM:617748 tudor domain containing 5 GO:0007286,GO:0030719,GO:0033391,GO:0043046,GO:0071546 spermatid development|P granule organization|chromatoid body|DNA methylation involved in gamete generation|pi-body TDRD7 560.548541916064 475.39934151138 645.697742320747 1.35822178522157 0.441719077751953 0.370041000055825 1 4.18621 4.75175 8.1097 4.17765 GeneID:23424,Genbank:NM_014290.2,HGNC:HGNC:30831,MIM:611258 tudor domain containing 7 GO:0002089,GO:0003729,GO:0005737,GO:0005759,GO:0007283,GO:0010608,GO:0033391,GO:0035770,GO:0047485,GO:0070306 lens morphogenesis in camera-type eye|mRNA binding|cytoplasm|mitochondrial matrix|spermatogenesis|posttranscriptional regulation of gene expression|chromatoid body|ribonucleoprotein granule|protein N-terminus binding|lens fiber cell differentiation TDRD9 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0157776 0 GeneID:122402,Genbank:XM_006720019.3,HGNC:HGNC:20122 tudor domain containing 9 GO:0003723,GO:0004004,GO:0005524,GO:0005634,GO:0005737,GO:0005739,GO:0006396,GO:0007140,GO:0007141,GO:0007275,GO:0007283,GO:0009566,GO:0010529,GO:0016887,GO:0030154,GO:0031047,GO:0034587,GO:0043046,GO:0043186,GO:0071547 RNA binding|ATP-dependent RNA helicase activity|ATP binding|nucleus|cytoplasm|mitochondrion|RNA processing|male meiotic nuclear division|male meiosis I|multicellular organism development|spermatogenesis|fertilization|negative regulation of transposition|ATPase activity|cell differentiation|gene silencing by RNA|piRNA metabolic process|DNA methylation involved in gamete generation|P granule|piP-body TDRKH 304.229192900449 280.863663247088 327.594722553811 1.16638342876562 0.222042128028955 0.274901642115673 1 1.86695 2.35484 2.56274 2.63798 GeneID:11022,Genbank:XM_017000123.2,HGNC:HGNC:11713,MIM:609501 tudor and KH domain containing GO:0003723,GO:0005739,GO:0007140,GO:0007283,GO:0009566,GO:0030154,GO:0031047,GO:0034587,GO:0043046,GO:0071546,GO:0071547 RNA binding|mitochondrion|male meiotic nuclear division|spermatogenesis|fertilization|cell differentiation|gene silencing by RNA|piRNA metabolic process|DNA methylation involved in gamete generation|pi-body|piP-body TDRP 53.3473585477645 53.8588109397701 52.8359061557589 0.981007661213405 -0.0276636916218209 0.969618724121556 1 0.607183 0.615715 0.736086 0.461299 GeneID:157695,Genbank:NM_175075.4,HGNC:HGNC:26951 testis development related protein GO:0005634,GO:0005737,GO:0005829,GO:0007283,GO:0043231 nucleus|cytoplasm|cytosol|spermatogenesis|intracellular membrane-bounded organelle TEAD1 1353.34954499964 1413.405090806 1293.29399919328 0.915020051651132 -0.128124736080102 0.737833750343106 1 6.91193 6.19893 7.8765 4.36847 GeneID:7003,Genbank:NM_021961.5,HGNC:HGNC:11714,MIM:189967 TEA domain transcription factor 1 GO:0000982,GO:0000987,GO:0001085,GO:0001134,GO:0001223,GO:0003677,GO:0003700,GO:0005654,GO:0006367,GO:0006461,GO:0035329,GO:0043565,GO:0045893,GO:0045944,GO:0046982,GO:0048568,GO:0071148,GO:1902895 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|transcription factor activity, transcription factor recruiting|transcription coactivator binding|DNA binding|DNA binding transcription factor activity|nucleoplasm|transcription initiation from RNA polymerase II promoter|protein complex assembly|hippo signaling|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|embryonic organ development|TEAD-1-YAP complex|positive regulation of pri-miRNA transcription from RNA polymerase II promoter hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species TEAD2 1108.46941553457 960.320745068051 1256.61808600109 1.30853997735105 0.387958000996626 0.0102061268946919 0.404607248379666 8.56597 8.55929 11.2314 11.7989 GeneID:8463,Genbank:NM_001256662.1,HGNC:HGNC:11715,MIM:601729 TEA domain transcription factor 2 GO:0001085,GO:0001134,GO:0001223,GO:0001570,GO:0001843,GO:0003143,GO:0003700,GO:0003705,GO:0005634,GO:0005654,GO:0005829,GO:0006355,GO:0006367,GO:0006461,GO:0030903,GO:0035329,GO:0043231,GO:0043565,GO:0044212,GO:0045893,GO:0045944,GO:0046982,GO:0048339,GO:0048368,GO:0048568,GO:0060548,GO:0071149,GO:0071300,GO:0097718,GO:2000736 RNA polymerase II transcription factor binding|transcription factor activity, transcription factor recruiting|transcription coactivator binding|vasculogenesis|neural tube closure|embryonic heart tube morphogenesis|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|nucleoplasm|cytosol|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|protein complex assembly|notochord development|hippo signaling|intracellular membrane-bounded organelle|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|paraxial mesoderm development|lateral mesoderm development|embryonic organ development|negative regulation of cell death|TEAD-2-YAP complex|cellular response to retinoic acid|disordered domain specific binding|regulation of stem cell differentiation hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species TEAD3 376.861639275637 376.195229908747 377.528048642527 1.00354289110498 0.00510227834686463 1 1 4.35907 4.6841 4.6252 4.36915 GeneID:7005,Genbank:NM_003214.3,HGNC:HGNC:11716,MIM:603170 TEA domain transcription factor 3 GO:0001085,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007565,GO:0035329,GO:0043565,GO:0044212,GO:0045944,GO:0048568,GO:0055059 RNA polymerase II transcription factor binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|female pregnancy|hippo signaling|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|embryonic organ development|asymmetric neuroblast division hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species TEAD4 236.946638345984 219.941938926067 253.951337765901 1.15462898529446 0.207429347690014 0.340217330194036 1 4.55045 4.1523 5.52268 4.78472 GeneID:7004,Genbank:NM_003213.3,HGNC:HGNC:11717,MIM:601714 TEA domain transcription factor 4 GO:0001085,GO:0001501,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0006357,GO:0006367,GO:0007517,GO:0035329,GO:0043565,GO:0044212,GO:0045944,GO:0048568 RNA polymerase II transcription factor binding|skeletal system development|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|muscle organ development|hippo signaling|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|embryonic organ development hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species TEC 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.00709166 0.00714043 0 GeneID:7006,Genbank:XM_024454193.1,HGNC:HGNC:11719,MIM:600583 tec protein tyrosine kinase GO:0002250,GO:0004715,GO:0005524,GO:0005543,GO:0005829,GO:0005856,GO:0005886,GO:0006468,GO:0007169,GO:0007229,GO:0010543,GO:0018108,GO:0019221,GO:0030154,GO:0031234,GO:0035556,GO:0038083,GO:0038095,GO:0042127,GO:0042246,GO:0045087,GO:0046872,GO:0050731,GO:0050853 adaptive immune response|non-membrane spanning protein tyrosine kinase activity|ATP binding|phospholipid binding|cytosol|cytoskeleton|plasma membrane|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|integrin-mediated signaling pathway|regulation of platelet activation|peptidyl-tyrosine phosphorylation|cytokine-mediated signaling pathway|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|intracellular signal transduction|peptidyl-tyrosine autophosphorylation|Fc-epsilon receptor signaling pathway|regulation of cell proliferation|tissue regeneration|innate immune response|metal ion binding|positive regulation of peptidyl-tyrosine phosphorylation|B cell receptor signaling pathway hsa04380,hsa04660 Osteoclast differentiation|T cell receptor signaling pathway TECPR1 1358.94510835313 1308.61133103055 1409.27888567572 1.07692700824001 0.106920470477531 0.475718502003897 1 7.9304 8.01071 8.75002 8.65605 GeneID:25851,Genbank:NM_015395.2,HGNC:HGNC:22214,MIM:614781 tectonin beta-propeller repeat containing 1 GO:0000421,GO:0005654,GO:0005765,GO:0006914,GO:0016021,GO:0031410,GO:0032266,GO:0043231,GO:0097352 autophagosome membrane|nucleoplasm|lysosomal membrane|autophagy|integral component of membrane|cytoplasmic vesicle|phosphatidylinositol-3-phosphate binding|intracellular membrane-bounded organelle|autophagosome maturation TECPR2 652.016288778408 649.333420584102 654.699156972714 1.00826345328689 0.0118726557916823 0.970730059173174 1 2.41222 2.68054 2.49861 2.70212 GeneID:9895,Genbank:NM_014844.4,HGNC:HGNC:19957,MIM:615000 tectonin beta-propeller repeat containing 2 GO:0006914 autophagy TECR 4790.55458298559 4736.40867957313 4844.70048639806 1.02286369571358 0.0326139079183028 0.82697652332229 1 62.5053 61.975 66.1886 67.8807 GeneID:9524,Genbank:XM_024451793.1,HGNC:HGNC:4551,MIM:610057 trans-2,3-enoyl-CoA reductase GO:0005634,GO:0005783,GO:0005789,GO:0016491,GO:0017099,GO:0030176,GO:0030497,GO:0035338,GO:0042761 nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|oxidoreductase activity|very-long-chain-acyl-CoA dehydrogenase activity|integral component of endoplasmic reticulum membrane|fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|very long-chain fatty acid biosynthetic process hsa00062,hsa01040 Fatty acid elongation|Biosynthesis of unsaturated fatty acids TECTA 21.5247446022841 20.7554866707331 22.2940025338351 1.07412574262937 0.103162892437955 0.883109461377357 1 0.109785 0.0863806 0.109154 0.0846983 GeneID:7007,Genbank:NM_005422.2,HGNC:HGNC:11720,MIM:602574 tectorin alpha GO:0005201,GO:0005576,GO:0005578,GO:0005886,GO:0006501,GO:0007160,GO:0007605,GO:0031225,GO:0070062 extracellular matrix structural constituent|extracellular region|proteinaceous extracellular matrix|plasma membrane|C-terminal protein lipidation|cell-matrix adhesion|sensory perception of sound|anchored component of membrane|extracellular exosome TEDC1 431.564925473831 441.027716790319 422.102134157343 0.957087543679315 -0.0632772025108262 0.715752696663878 1 11.2554 11.5209 10.8519 11.2837 GeneID:283643,Genbank:NM_001198983.1,HGNC:HGNC:20127 tubulin epsilon and delta complex 1 TEDC2 374.060476612651 383.70018841727 364.420764808033 0.949753937602264 -0.0743743066888436 0.674500236340078 1 9.29712 10.3905 8.66449 10.1091 GeneID:80178,Genbank:XM_011522667.2,HGNC:HGNC:25849 tubulin epsilon and delta complex 2 TEF 293.523994486748 275.424851550872 311.623137422623 1.13142708680036 0.178143615182864 0.387046233584817 1 2.6356 2.8045 3.24671 2.94012 GeneID:7008,Genbank:NM_001145398.2,HGNC:HGNC:11722,MIM:188595 TEF, PAR bZIP transcription factor GO:0000977,GO:0001077,GO:0005634,GO:0006357,GO:0007275,GO:0048511 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|regulation of transcription from RNA polymerase II promoter|multicellular organism development|rhythmic process TEFM 167.485423983514 166.803522106571 168.167325860457 1.00817610885347 0.0117476717521117 0.957609979946003 1 2.77114 2.35393 2.69103 2.52863 GeneID:79736,Genbank:XM_006722084.2,HGNC:HGNC:26223,MIM:616422 transcription elongation factor, mitochondrial GO:0003723,GO:0005739,GO:0005759,GO:0006119,GO:0006355,GO:0006390,GO:0030337,GO:0030529,GO:0042645 RNA binding|mitochondrion|mitochondrial matrix|oxidative phosphorylation|regulation of transcription, DNA-templated|transcription from mitochondrial promoter|DNA polymerase processivity factor activity|intracellular ribonucleoprotein complex|mitochondrial nucleoid TEK 1.72838687339946 1.51824048055703 1.93853326624189 1.27682886279692 0.352565169253837 1 1 0.00791241 0.0148325 0.0151248 0.00703457 GeneID:7010,Genbank:NM_000459.4,HGNC:HGNC:11724,MIM:600221 TEK receptor tyrosine kinase hsa04010,hsa04014,hsa04015,hsa04066,hsa04151,hsa05323 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|Rheumatoid arthritis TEKT2 3.55782939553899 4.20872886376855 2.90692992730943 0.690690710046484 -0.533888275697058 0.8441200164292 1 0.0413877 0.018059 0.0384483 0.0536803 GeneID:27285,Genbank:NM_014466.2,HGNC:HGNC:11725,MIM:608953 tektin 2 GO:0005634,GO:0005737,GO:0005815,GO:0005874,GO:0030317,GO:0036126,GO:0036159,GO:0060271,GO:0060294 nucleus|cytoplasm|microtubule organizing center|microtubule|flagellated sperm motility|sperm flagellum|inner dynein arm assembly|cilium assembly|cilium movement involved in cell motility TEKT3 4.64869452118777 3.96859749034384 5.32879155203169 1.34273923344391 0.425179153502861 0.861321688702504 1 0.00678127 0.0314036 0.0193407 0.0420469 GeneID:64518,Genbank:XM_017024954.1,HGNC:HGNC:14293,MIM:612683 tektin 3 GO:0002080,GO:0005634,GO:0005874,GO:0030317,GO:0036126,GO:0060271,GO:0060294,GO:0070062,GO:0080154 acrosomal membrane|nucleus|microtubule|flagellated sperm motility|sperm flagellum|cilium assembly|cilium movement involved in cell motility|extracellular exosome|regulation of fertilization TEKT4 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:150483,Genbank:NM_001286559.1,HGNC:HGNC:31012 tektin 4 GO:0005634,GO:0005737,GO:0005874,GO:0030317,GO:0036126,GO:0060271,GO:0060294 nucleus|cytoplasm|microtubule|flagellated sperm motility|sperm flagellum|cilium assembly|cilium movement involved in cell motility TELO2 1046.65801715112 1052.87659645309 1040.43943784914 0.988187448893964 -0.0171433628556598 0.891712117936713 1 11.6877 12.5122 11.7397 12.7195 GeneID:9894,Genbank:XM_011522775.3,HGNC:HGNC:29099,MIM:611140 telomere maintenance 2 GO:0000781,GO:0005622,GO:0005634,GO:0005737,GO:0005829,GO:0016020,GO:0016604,GO:0019901,GO:0031931,GO:0031932,GO:0032006,GO:0032403,GO:0032947,GO:0034399,GO:0050821,GO:0051879,GO:0071902,GO:1904263,GO:1904515 chromosome, telomeric region|intracellular|nucleus|cytoplasm|cytosol|membrane|nuclear body|protein kinase binding|TORC1 complex|TORC2 complex|regulation of TOR signaling|protein complex binding|protein complex scaffold activity|nuclear periphery|protein stabilization|Hsp90 protein binding|positive regulation of protein serine/threonine kinase activity|positive regulation of TORC1 signaling|positive regulation of TORC2 signaling hsa03460,hsa04150 Fanconi anemia pathway|mTOR signaling pathway TEN1 469.926311672615 515.353856752712 424.498766592517 0.8237034826271 -0.279803006424506 0.109833015471967 1 24.3757 25.5064 18.5275 21.9525 GeneID:100134934,Genbank:NM_001113324.2,HGNC:HGNC:37242,MIM:613130 TEN1, CST complex subunit GO:0000784,GO:0003697,GO:0005634,GO:0016233,GO:0032211,GO:0042162,GO:1990879 nuclear chromosome, telomeric region|single-stranded DNA binding|nucleus|telomere capping|negative regulation of telomere maintenance via telomerase|telomeric DNA binding|CST complex TENM1 197.700386130475 192.767497755203 202.633274505748 1.05117966911141 0.072009277846893 0.885183130556355 1 0.429268 0.435583 0.610634 0.294185 GeneID:10178,Genbank:XM_017029210.2,HGNC:HGNC:8117,MIM:300588 teneurin transmembrane protein 1 GO:0000902,GO:0005576,GO:0005634,GO:0005737,GO:0005783,GO:0005794,GO:0005856,GO:0005886,GO:0005887,GO:0006351,GO:0006359,GO:0006955,GO:0007157,GO:0007218,GO:0007399,GO:0008201,GO:0008285,GO:0016363,GO:0016607,GO:0030838,GO:0033138,GO:0042803,GO:0043005,GO:0043406,GO:0046982,GO:0048471,GO:0048666,GO:0050839,GO:0051491,GO:0090316 cell morphogenesis|extracellular region|nucleus|cytoplasm|endoplasmic reticulum|Golgi apparatus|cytoskeleton|plasma membrane|integral component of plasma membrane|transcription, DNA-templated|regulation of transcription from RNA polymerase III promoter|immune response|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|neuropeptide signaling pathway|nervous system development|heparin binding|negative regulation of cell proliferation|nuclear matrix|nuclear speck|positive regulation of actin filament polymerization|positive regulation of peptidyl-serine phosphorylation|protein homodimerization activity|neuron projection|positive regulation of MAP kinase activity|protein heterodimerization activity|perinuclear region of cytoplasm|neuron development|cell adhesion molecule binding|positive regulation of filopodium assembly|positive regulation of intracellular protein transport TENM2 9990.06867940061 9429.45566805142 10550.6816907498 1.11890676006859 0.162089819700159 0.216891719647346 1 19.068 19.6974 24.4086 19.7448 GeneID:57451,Genbank:XM_017009660.1,HGNC:HGNC:29943,MIM:610119 teneurin transmembrane protein 2 GO:0000122,GO:0000902,GO:0005102,GO:0005509,GO:0005622,GO:0005634,GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0005911,GO:0006351,GO:0007157,GO:0007165,GO:0007411,GO:0016605,GO:0030054,GO:0030175,GO:0030425,GO:0030426,GO:0035584,GO:0042803,GO:0043005,GO:0043197,GO:0045202,GO:0045211,GO:0046982,GO:0048666,GO:0050839,GO:0051491,GO:0097264,GO:0098609 negative regulation of transcription from RNA polymerase II promoter|cell morphogenesis|receptor binding|calcium ion binding|intracellular|nucleus|endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|cell-cell junction|transcription, DNA-templated|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|axon guidance|PML body|cell junction|filopodium|dendrite|growth cone|calcium-mediated signaling using intracellular calcium source|protein homodimerization activity|neuron projection|dendritic spine|synapse|postsynaptic membrane|protein heterodimerization activity|neuron development|cell adhesion molecule binding|positive regulation of filopodium assembly|self proteolysis|cell-cell adhesion TENM3 3994.63627832554 3898.09776893052 4091.17478772057 1.04953108675954 0.0697448994072107 0.658663486386348 1 12.2213 11.7457 14.5431 10.9954 GeneID:55714,Genbank:XM_017008385.1,HGNC:HGNC:29944,MIM:610083 teneurin transmembrane protein 3 GO:0000902,GO:0005887,GO:0007156,GO:0007157,GO:0007165,GO:0010976,GO:0016020,GO:0030424,GO:0042803,GO:0043005,GO:0046982,GO:0048593,GO:0048666,GO:0050839,GO:0097264 cell morphogenesis|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|positive regulation of neuron projection development|membrane|axon|protein homodimerization activity|neuron projection|protein heterodimerization activity|camera-type eye morphogenesis|neuron development|cell adhesion molecule binding|self proteolysis TENM4 989.200709461534 940.19940862333 1038.20201029974 1.10423597460023 0.143048508173218 0.472786086645237 1 1.98638 2.03142 2.61964 1.90122 GeneID:26011,Genbank:XM_017017525.1,HGNC:HGNC:29945,MIM:610084 teneurin transmembrane protein 4 GO:0000902,GO:0001702,GO:0005634,GO:0005737,GO:0005886,GO:0005887,GO:0007157,GO:0007165,GO:0031641,GO:0031643,GO:0032289,GO:0042803,GO:0043005,GO:0046982,GO:0048666,GO:0048714,GO:0050839,GO:0060038,GO:0060912,GO:0097264,GO:2000543 cell morphogenesis|gastrulation with mouth forming second|nucleus|cytoplasm|plasma membrane|integral component of plasma membrane|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|signal transduction|regulation of myelination|positive regulation of myelination|central nervous system myelin formation|protein homodimerization activity|neuron projection|protein heterodimerization activity|neuron development|positive regulation of oligodendrocyte differentiation|cell adhesion molecule binding|cardiac muscle cell proliferation|cardiac cell fate specification|self proteolysis|positive regulation of gastrulation TEP1 274.288710700214 273.320487118987 275.25693428144 1.00708489576784 0.0101853055301195 0.982840222948835 1 0.819839 0.885007 0.877516 0.888626 GeneID:7011,Genbank:XM_005268027.5,HGNC:HGNC:11726,MIM:601686 telomerase associated protein 1 GO:0000722,GO:0000781,GO:0002039,GO:0003720,GO:0003723,GO:0005524,GO:0005682,GO:0005697,GO:0005737,GO:0008380,GO:0016363,GO:0019899,GO:0030529,GO:0070034,GO:0071011,GO:0071013 telomere maintenance via recombination|chromosome, telomeric region|p53 binding|telomerase activity|RNA binding|ATP binding|U5 snRNP|telomerase holoenzyme complex|cytoplasm|RNA splicing|nuclear matrix|enzyme binding|intracellular ribonucleoprotein complex|telomerase RNA binding|precatalytic spliceosome|catalytic step 2 spliceosome TEPSIN 284.608781797345 296.39206063056 272.82550296413 0.920488566339148 -0.119528293342877 0.543041354400551 1 3.17667 3.14364 2.59064 2.951 GeneID:146705,Genbank:XM_006721709.3,HGNC:HGNC:26458 TEPSIN, adaptor related protein complex 4 accessory protein GO:0005737,GO:0005794,GO:0005829,GO:0016607,GO:0030124,GO:0030662,GO:0031312,GO:0031965,GO:0032588 cytoplasm|Golgi apparatus|cytosol|nuclear speck|AP-4 adaptor complex|coated vesicle membrane|extrinsic component of organelle membrane|nuclear membrane|trans-Golgi network membrane TERB1 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.011329 0.0112963 0 GeneID:283847,Genbank:XM_011523009.2,HGNC:HGNC:26675,MIM:617332 telomere repeat binding bouquet formation protein 1 GO:0000781,GO:0000784,GO:0003677,GO:0005637,GO:0007129,GO:0045141,GO:0070187,GO:0070197 chromosome, telomeric region|nuclear chromosome, telomeric region|DNA binding|nuclear inner membrane|synapsis|meiotic telomere clustering|shelterin complex|meiotic attachment of telomere to nuclear envelope TERF1 369.105800493434 402.830556402114 335.381044584754 0.832561083697856 -0.264371970553198 0.171121329440966 1 3.42168 3.15927 3.02383 2.54172 GeneID:7013,Genbank:XM_011517582.3,HGNC:HGNC:11728,MIM:600951 telomeric repeat binding factor 1 TERF2 854.25992856871 904.538849139174 803.981007998247 0.888829715565423 -0.170021044832008 0.288906606425269 1 10.3311 9.27665 8.82521 8.86798 GeneID:7014,Genbank:NM_005652.4,HGNC:HGNC:11729,MIM:602027 telomeric repeat binding factor 2 GO:0000723,GO:0000781,GO:0000783,GO:0000784,GO:0003691,GO:0005634,GO:0005654,GO:0006278,GO:0007049,GO:0008022,GO:0010628,GO:0010629,GO:0016233,GO:0016604,GO:0019899,GO:0031627,GO:0031848,GO:0032204,GO:0032205,GO:0032208,GO:0032210,GO:0032211,GO:0032214,GO:0042162,GO:0042803,GO:0044877,GO:0051000,GO:0061820,GO:0070187,GO:0070198,GO:0090398,GO:0098505,GO:1903770,GO:1903824,GO:1904354,GO:1904357,GO:1904430,GO:1905778,GO:1905839,GO:2000773 telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|nuclear chromosome, telomeric region|double-stranded telomeric DNA binding|nucleus|nucleoplasm|RNA-dependent DNA biosynthetic process|cell cycle|protein C-terminus binding|positive regulation of gene expression|negative regulation of gene expression|telomere capping|nuclear body|enzyme binding|telomeric loop formation|protection from non-homologous end joining at telomere|regulation of telomere maintenance|negative regulation of telomere maintenance|negative regulation of telomere maintenance via recombination|regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via telomerase|negative regulation of telomere maintenance via semi-conservative replication|telomeric DNA binding|protein homodimerization activity|macromolecular complex binding|positive regulation of nitric-oxide synthase activity|telomeric D-loop disassembly|shelterin complex|protein localization to chromosome, telomeric region|cellular senescence|G-rich strand telomeric DNA binding|negative regulation of beta-galactosidase activity|negative regulation of telomere single strand break repair|negative regulation of telomere capping|negative regulation of telomere maintenance via telomere lengthening|negative regulation of t-circle formation|negative regulation of exonuclease activity|negative regulation of telomeric D-loop disassembly|negative regulation of cellular senescence TERF2IP 1754.57686147183 1721.83823107739 1787.31549186627 1.03802753336933 0.0538447112570374 0.700631536089715 1 34.281 33.7776 36.7735 34.6555 GeneID:54386,Genbank:NM_018975.3,HGNC:HGNC:19246,MIM:605061 TERF2 interacting protein GO:0000228,GO:0000723,GO:0000781,GO:0000783,GO:0000784,GO:0001933,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0007004,GO:0010569,GO:0010833,GO:0016233,GO:0016604,GO:0019902,GO:0031848,GO:0032204,GO:0032205,GO:0033138,GO:0042162,GO:0043123,GO:0048239,GO:0051092,GO:0070187,GO:0070198,GO:0098505,GO:1901224,GO:1901985 nuclear chromosome|telomere maintenance|chromosome, telomeric region|nuclear telomere cap complex|nuclear chromosome, telomeric region|negative regulation of protein phosphorylation|nucleus|nuclear envelope|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|telomere maintenance via telomerase|regulation of double-strand break repair via homologous recombination|telomere maintenance via telomere lengthening|telomere capping|nuclear body|phosphatase binding|protection from non-homologous end joining at telomere|regulation of telomere maintenance|negative regulation of telomere maintenance|positive regulation of peptidyl-serine phosphorylation|telomeric DNA binding|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of DNA recombination at telomere|positive regulation of NF-kappaB transcription factor activity|shelterin complex|protein localization to chromosome, telomeric region|G-rich strand telomeric DNA binding|positive regulation of NIK/NF-kappaB signaling|positive regulation of protein acetylation TERT 13.8612130950947 15.1245698757774 12.5978563144121 0.832939807074318 -0.263715852805637 0.797354187199549 1 0.241549 0.101185 0.137401 0.179939 GeneID:7015,Genbank:NM_001193376.1,HGNC:HGNC:11730,MIM:187270 telomerase reverse transcriptase hsa05165,hsa05166,hsa05200,hsa05225,hsa05226 Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Hepatocellular carcinoma|Gastric cancer TES 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0 0.015266 0.0141524 GeneID:26136,Genbank:NM_015641.3,HGNC:HGNC:14620,MIM:606085 testin LIM domain protein GO:0003723,GO:0005634,GO:0005829,GO:0005886,GO:0005925,GO:0008270,GO:0008285,GO:0030054,GO:0043234,GO:0045296 RNA binding|nucleus|cytosol|plasma membrane|focal adhesion|zinc ion binding|negative regulation of cell proliferation|cell junction|protein complex|cadherin binding TESK1 670.836562977909 593.388845521809 748.284280434009 1.26103529933393 0.33460866064728 0.041953403263333 0.765291237660069 10.4641 10.1223 13.9636 12.4687 GeneID:7016,Genbank:NM_006285.2,HGNC:HGNC:11731,MIM:601782 testis associated actin remodelling kinase 1 GO:0004674,GO:0004712,GO:0004713,GO:0004871,GO:0005524,GO:0005737,GO:0005829,GO:0007283,GO:0008022,GO:0019901,GO:0031410,GO:0031953,GO:0032880,GO:0035556,GO:0046872,GO:0051496,GO:0071901 protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|signal transducer activity|ATP binding|cytoplasm|cytosol|spermatogenesis|protein C-terminus binding|protein kinase binding|cytoplasmic vesicle|negative regulation of protein autophosphorylation|regulation of protein localization|intracellular signal transduction|metal ion binding|positive regulation of stress fiber assembly|negative regulation of protein serine/threonine kinase activity TESK2 93.7470133822059 93.4673336031998 94.026693161212 1.00598454600606 0.00860814254734943 0.993442905748542 1 0.977667 0.887324 1.12941 0.805151 GeneID:10420,Genbank:NM_001320800.1,HGNC:HGNC:11732,MIM:604746 testis associated actin remodelling kinase 2 GO:0004672,GO:0004674,GO:0004712,GO:0004713,GO:0004871,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006468,GO:0007283,GO:0016604,GO:0030036,GO:0035556,GO:0046872,GO:0048041 protein kinase activity|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|signal transducer activity|ATP binding|nucleus|nucleoplasm|cytoplasm|protein phosphorylation|spermatogenesis|nuclear body|actin cytoskeleton organization|intracellular signal transduction|metal ion binding|focal adhesion assembly TESMIN 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0087195 0.00896514 0 GeneID:9633,Genbank:XM_017018588.1,HGNC:HGNC:7446,MIM:604374 testis expressed metallothionein like protein GO:0005634,GO:0005737,GO:0006875,GO:0007275,GO:0007283,GO:0010038,GO:0030154,GO:0046872 nucleus|cytoplasm|cellular metal ion homeostasis|multicellular organism development|spermatogenesis|response to metal ion|cell differentiation|metal ion binding TET1 47.0435131568097 49.0061231948815 45.0809031187379 0.919903476948499 -0.120445603971211 0.810566846349577 1 0.122791 0.108114 0.140297 0.0779647 GeneID:80312,Genbank:XM_011540204.2,HGNC:HGNC:29484,MIM:607790 tet methylcytosine dioxygenase 1 GO:0001826,GO:0003677,GO:0005506,GO:0005634,GO:0006351,GO:0006493,GO:0008270,GO:0008284,GO:0016569,GO:0019827,GO:0031062,GO:0045944,GO:0070579,GO:0080111,GO:0090310 inner cell mass cell differentiation|DNA binding|iron ion binding|nucleus|transcription, DNA-templated|protein O-linked glycosylation|zinc ion binding|positive regulation of cell proliferation|covalent chromatin modification|stem cell population maintenance|positive regulation of histone methylation|positive regulation of transcription from RNA polymerase II promoter|methylcytosine dioxygenase activity|DNA demethylation|negative regulation of methylation-dependent chromatin silencing TET2 246.81191966759 246.385160320694 247.238679014486 1.00346416437046 0.0049890962140647 0.97921949177091 1 0.701199 0.486583 0.846746 0.372851 GeneID:54790,Genbank:NM_017628.4,HGNC:HGNC:25941,MIM:612839 tet methylcytosine dioxygenase 2 GO:0003677,GO:0006211,GO:0006493,GO:0007049,GO:0008198,GO:0008270,GO:0014070,GO:0030099,GO:0045944,GO:0070579,GO:0080111,GO:0080182 DNA binding|5-methylcytosine catabolic process|protein O-linked glycosylation|cell cycle|ferrous iron binding|zinc ion binding|response to organic cyclic compound|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|methylcytosine dioxygenase activity|DNA demethylation|histone H3-K4 trimethylation TET3 357.649780814803 372.629442925244 342.670118704362 0.919600222715381 -0.120921279428989 0.547095851911407 1 1.14851 0.951315 1.16463 0.838928 GeneID:200424,Genbank:XM_017003566.1,HGNC:HGNC:28313,MIM:613555 tet methylcytosine dioxygenase 3 GO:0001940,GO:0003677,GO:0005694,GO:0005737,GO:0006493,GO:0044727,GO:0045944,GO:0046872,GO:0070579,GO:0080111,GO:0080182 male pronucleus|DNA binding|chromosome|cytoplasm|protein O-linked glycosylation|DNA demethylation of male pronucleus|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|methylcytosine dioxygenase activity|DNA demethylation|histone H3-K4 trimethylation TEX10 559.020850734744 589.304578171879 528.737123297608 0.897222154522943 -0.156462850493305 0.36232364484331 1 6.35805 6.67214 6.13075 5.62521 GeneID:54881,Genbank:NM_017746.3,HGNC:HGNC:25988,MIM:616717 testis expressed 10 GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0071339,GO:0097344 nucleoplasm|nucleolus|cytoplasm|rRNA processing|MLL1 complex|Rix1 complex TEX101 1.0012194055454 1.51824048055703 0.484198330533773 0.31892070902768 -1.64873031325362 0.791516662337547 1 0 0 0 0.0209776 GeneID:83639,Genbank:NM_031451.4,HGNC:HGNC:30722,MIM:612665 testis expressed 101 GO:0001669,GO:0005576,GO:0005886,GO:0006501,GO:0007339,GO:0009566,GO:0045121,GO:0046658,GO:0097722,GO:1901317 acrosomal vesicle|extracellular region|plasma membrane|C-terminal protein lipidation|binding of sperm to zona pellucida|fertilization|membrane raft|anchored component of plasma membrane|sperm motility|regulation of flagellated sperm motility TEX11 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00964268 0 0 0 GeneID:56159,Genbank:XM_017029649.1,HGNC:HGNC:11733,MIM:300311 testis expressed 11 GO:0000712,GO:0000801,GO:0006311,GO:0007060,GO:0007130,GO:0007131,GO:0008584,GO:0009566,GO:0043066,GO:0051026 resolution of meiotic recombination intermediates|central element|meiotic gene conversion|male meiosis chromosome segregation|synaptonemal complex assembly|reciprocal meiotic recombination|male gonad development|fertilization|negative regulation of apoptotic process|chiasma assembly TEX12 1.70687528574208 1.96028560782945 1.45346496365472 0.741455713315206 -0.431567570904168 0.968962084792157 1 0 0.0517553 0 0.0943732 GeneID:56158,Genbank:NM_031275.4,HGNC:HGNC:11734,MIM:605791 testis expressed 12 GO:0000711,GO:0000801,GO:0007130 meiotic DNA repair synthesis|central element|synaptonemal complex assembly TEX13B 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:56156,Genbank:NM_031273.2,HGNC:HGNC:11736,MIM:300313 testis expressed 13B TEX13D 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00872301 0 0 0.0077246 GeneID:100132015,Genbank:NM_001355534.1,HGNC:HGNC:52278 TEX13 family member D GO:0046872 metal ion binding TEX14 7.94552307996269 8.61937148138481 7.27167467854057 0.843643262649156 -0.245295015392284 0.856980694077883 1 0.0247015 0.0404345 0.0352941 0.0164593 GeneID:56155,Genbank:NM_031272.4,HGNC:HGNC:11737,MIM:605792 testis expressed 14, intercellular bridge forming factor GO:0000776,GO:0000777,GO:0004672,GO:0005524,GO:0005623,GO:0005737,GO:0007094,GO:0007140,GO:0008608,GO:0019901,GO:0030496,GO:0032091,GO:0032466,GO:0043063,GO:0045171,GO:0051301,GO:0051306,GO:0070062,GO:1990830 kinetochore|condensed chromosome kinetochore|protein kinase activity|ATP binding|cell|cytoplasm|mitotic spindle assembly checkpoint|male meiotic nuclear division|attachment of spindle microtubules to kinetochore|protein kinase binding|midbody|negative regulation of protein binding|negative regulation of cytokinesis|intercellular bridge organization|intercellular bridge|cell division|mitotic sister chromatid separation|extracellular exosome|cellular response to leukemia inhibitory factor TEX15 2.51239022307384 3.084507235799 1.94027321034868 0.62903830726339 -0.668780217661813 0.833661370103449 1 0.00839318 0.00551884 0.00544317 0 GeneID:56154,Genbank:NM_001350162.1,HGNC:HGNC:11738,MIM:605795 testis expressed 15, meiosis and synapsis associated GO:0005634,GO:0005737,GO:0006281,GO:0007130,GO:0007140,GO:0007283,GO:0009566,GO:0010569,GO:0030154,GO:0030539,GO:0032880,GO:0034502,GO:0048873 nucleus|cytoplasm|DNA repair|synaptonemal complex assembly|male meiotic nuclear division|spermatogenesis|fertilization|regulation of double-strand break repair via homologous recombination|cell differentiation|male genitalia development|regulation of protein localization|protein localization to chromosome|homeostasis of number of cells within a tissue TEX19 5.25926659588418 5.18887166768327 5.32966152408509 1.02713303882204 0.0386230580126423 1 1 0.115855 0.0519509 0.0362945 0.118735 GeneID:400629,Genbank:NM_207459.3,HGNC:HGNC:33802,MIM:615647 testis expressed 19 GO:0005737,GO:0007131,GO:0007140,GO:0007283,GO:0010529,GO:0030154,GO:0034584 cytoplasm|reciprocal meiotic recombination|male meiotic nuclear division|spermatogenesis|negative regulation of transposition|cell differentiation|piRNA binding TEX2 1962.39574952272 1777.72497120989 2147.06652783554 1.20776079686515 0.272334749904485 0.0530672993253122 0.840678403555093 4.68079 4.87569 6.46172 5.07343 GeneID:55852,Genbank:NM_001288732.1,HGNC:HGNC:30884 testis expressed 2 GO:0005783,GO:0006665,GO:0006869,GO:0007165,GO:0008289,GO:0016021 endoplasmic reticulum|sphingolipid metabolic process|lipid transport|signal transduction|lipid binding|integral component of membrane TEX22 19.152755771419 16.0184687854302 22.2870427574079 1.39133415658801 0.476468953421842 0.629179772039025 1 0.102654 0.281871 0.227844 0.408447 GeneID:647310,Genbank:XM_006720234.3,HGNC:HGNC:40026 testis expressed 22 GO:0001669 acrosomal vesicle TEX261 2921.02874085751 2946.62875206388 2895.42872965114 0.98262420320956 -0.025288320056148 0.864095501172269 1 42.4548 41.4297 39.0123 43.7258 GeneID:113419,Genbank:NM_144582.2,HGNC:HGNC:30712 testis expressed 261 GO:0006888,GO:0030134,GO:0030173,GO:0030176,GO:0097020 ER to Golgi vesicle-mediated transport|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|integral component of endoplasmic reticulum membrane|COPII adaptor activity TEX264 1586.10146107111 1454.70942674278 1717.49349539943 1.18064368307906 0.239573626701301 0.10563119924245 1 13.6702 16.5551 17.8604 19.4731 GeneID:51368,Genbank:NM_001278195.1,HGNC:HGNC:30247 testis expressed 264 GO:0002576,GO:0005576,GO:0031093,GO:0070062 platelet degranulation|extracellular region|platelet alpha granule lumen|extracellular exosome TEX29 1.24375355683899 1.51824048055703 0.969266633120943 0.638414431398462 -0.647434830746163 0.97445271569056 1 0.0200431 0.0361118 0.018779 0.0175143 GeneID:121793,Genbank:XM_017020388.1,HGNC:HGNC:20370 testis expressed 29 GO:0016021 integral component of membrane TEX30 306.265376947773 333.87660155189 278.654152343657 0.83460221844971 -0.260839339464414 0.189638810684594 1 3.00745 3.29474 2.58655 2.76771 GeneID:93081,Genbank:NM_001286776.1,HGNC:HGNC:25188 testis expressed 30 GO:0016787 hydrolase activity TEX38 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:374973,Genbank:XM_011541421.3,HGNC:HGNC:29589 testis expressed 38 GO:0016021 integral component of membrane TEX43 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:389320,Genbank:NM_207408.2,HGNC:HGNC:33767 testis expressed 43 TEX45 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:374877,Genbank:NM_198534.2,HGNC:HGNC:24745 testis expressed 45 TEX46 0.969266633120943 0 1.93853326624189 Inf Inf 0.451830900262006 1 0 0 0.241234 0 GeneID:729059,Genbank:NM_001242521.1,HGNC:HGNC:44651 testis expressed 46 TEX48 9.69824971025622 10.6757096385841 8.72078978192829 0.816881507380982 -0.291801271243098 0.790327588279986 1 0.196158 0.302756 0.184872 0.288616 GeneID:100505478,Genbank:NM_001199233.1,HGNC:HGNC:52393 testis expressed 48 TEX49 24.9945469491566 22.36977970066 27.6193141976532 1.23467081782832 0.304126448457657 0.588421812090979 1 0.237174 0.150835 0.213423 0.299648 GeneID:255411,Genbank:NM_001351125.1,HGNC:HGNC:48628 testis expressed 49 TEX9 49.1596966909677 46.4597136357248 51.8596797462107 1.11622900116917 0.158633035195046 0.700477550705766 1 0.383226 0.263325 0.331446 0.293453 GeneID:374618,Genbank:XM_005254361.4,HGNC:HGNC:29585 testis expressed 9 TF 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.00990176 0.00919771 GeneID:7018,Genbank:NM_001354703.1,HGNC:HGNC:11740,MIM:190000 transferrin hsa04066,hsa04216,hsa04978 HIF-1 signaling pathway|Ferroptosis|Mineral absorption TFAM 870.750718576327 1067.32473047986 674.176706672793 0.631650975022089 -0.662800491700524 0.00279865544151191 0.195734784066614 10.1197 8.5997 6.89604 5.32441 GeneID:7019,Genbank:NM_003201.2,HGNC:HGNC:11741,MIM:600438 transcription factor A, mitochondrial GO:0000978,GO:0001018,GO:0001077,GO:0001223,GO:0003682,GO:0003700,GO:0003723,GO:0005634,GO:0005739,GO:0005759,GO:0005829,GO:0006261,GO:0006356,GO:0006390,GO:0006391,GO:0007005,GO:0008301,GO:0031072,GO:0033108,GO:0042645,GO:0045893,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|mitochondrial promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcription coactivator binding|chromatin binding|DNA binding transcription factor activity|RNA binding|nucleus|mitochondrion|mitochondrial matrix|cytosol|DNA-dependent DNA replication|regulation of transcription from RNA polymerase I promoter|transcription from mitochondrial promoter|transcription initiation from mitochondrial promoter|mitochondrion organization|DNA binding, bending|heat shock protein binding|mitochondrial respiratory chain complex assembly|mitochondrial nucleoid|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter hsa04371,hsa05016 Apelin signaling pathway|Huntington disease TFAP2A 1190.17350530264 1139.65440121656 1240.69260938873 1.0886568841083 0.122549326328006 0.412455121922746 1 11.0865 10.6249 12.9327 11.3798 GeneID:7020,Genbank:XM_017011232.1,HGNC:HGNC:11742,MIM:107580 transcription factor AP-2 alpha TFAP2C 1050.36198563884 1061.6762303764 1039.04774090128 0.978686073185326 -0.0310819248316078 0.850509883156556 1 15.4659 14.5883 15.5467 14.5705 GeneID:7022,Genbank:NM_003222.3,HGNC:HGNC:11744,MIM:601602 transcription factor AP-2 gamma TFAP2E 8.74679652350255 9.253521707397 8.24007133960811 0.890479495284615 -0.167345703540013 0.928313464062183 1 0.0569693 0.0462189 0.0538124 0.0390075 GeneID:339488,Genbank:XM_017001139.2,HGNC:HGNC:30774,MIM:614428 transcription factor AP-2 epsilon TFAP4 168.027619380424 160.634507634973 175.420731125876 1.09204886116067 0.127037407702057 0.592908342981076 1 1.99142 1.78121 1.99299 2.3243 GeneID:7023,Genbank:NM_003223.2,HGNC:HGNC:11745,MIM:600743 transcription factor AP-4 GO:0001077,GO:0003677,GO:0003705,GO:0005634,GO:0005739,GO:0006461,GO:0006978,GO:0008285,GO:0017053,GO:0042803,GO:0042826,GO:0043065,GO:0043392,GO:0043565,GO:0043922,GO:0043923,GO:0044212,GO:0045736,GO:0045892,GO:0045893,GO:0070888,GO:0071157,GO:0071549,GO:1901990,GO:2001269 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|mitochondrion|protein complex assembly|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of cell proliferation|transcriptional repressor complex|protein homodimerization activity|histone deacetylase binding|positive regulation of apoptotic process|negative regulation of DNA binding|sequence-specific DNA binding|negative regulation by host of viral transcription|positive regulation by host of viral transcription|transcription regulatory region DNA binding|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|E-box binding|negative regulation of cell cycle arrest|cellular response to dexamethasone stimulus|regulation of mitotic cell cycle phase transition|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway hsa05205 Proteoglycans in cancer TFB1M 354.217109666195 378.405455545109 330.028763787281 0.872156463262033 -0.197341119835457 0.29069585675441 1 1.38393 1.77443 1.39074 1.44796 GeneID:51106,Genbank:XM_011535871.2,HGNC:HGNC:17037,MIM:607033 transcription factor B1, mitochondrial GO:0000154,GO:0000179,GO:0003677,GO:0003723,GO:0005759,GO:0006351,GO:0006355,GO:0007005,GO:0042645 rRNA modification|rRNA (adenine-N6,N6-)-dimethyltransferase activity|DNA binding|RNA binding|mitochondrial matrix|transcription, DNA-templated|regulation of transcription, DNA-templated|mitochondrion organization|mitochondrial nucleoid TFB2M 331.393573817209 386.54354727879 276.243600355629 0.714650657863373 -0.484689912201315 0.0131202923303983 0.471153816062017 9.38915 9.12757 7.14813 6.44651 GeneID:64216,Genbank:NM_022366.2,HGNC:HGNC:18559,MIM:607055 transcription factor B2, mitochondrial GO:0000179,GO:0003712,GO:0003723,GO:0005739,GO:0005759,GO:0006390,GO:0006391,GO:0007005,GO:0042645,GO:0045893 rRNA (adenine-N6,N6-)-dimethyltransferase activity|transcription cofactor activity|RNA binding|mitochondrion|mitochondrial matrix|transcription from mitochondrial promoter|transcription initiation from mitochondrial promoter|mitochondrion organization|mitochondrial nucleoid|positive regulation of transcription, DNA-templated TFCP2 572.195420959201 588.988011559301 555.402830359101 0.942978158228916 -0.0847037400842984 0.610222837951541 1 5.23654 5.54565 5.60733 4.88296 GeneID:7024,Genbank:NM_001173453.1,HGNC:HGNC:11748,MIM:189889 transcription factor CP2 GO:0000978,GO:0000987,GO:0001077,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0008022,GO:0008134,GO:0042789,GO:0043234,GO:0043565 RNA polymerase II proximal promoter sequence-specific DNA binding|proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|regulation of transcription from RNA polymerase II promoter|protein C-terminus binding|transcription factor binding|mRNA transcription from RNA polymerase II promoter|protein complex|sequence-specific DNA binding TFCP2L1 2.74861631691714 2.10436443188427 3.39286820195 1.61230067879069 0.689120817903757 0.791559124435026 1 0.0142583 0 0.0180135 0.0126033 GeneID:29842,Genbank:XM_017003902.1,HGNC:HGNC:17925,MIM:609785 transcription factor CP2 like 1 GO:0000122,GO:0000902,GO:0000977,GO:0001650,GO:0002070,GO:0003700,GO:0003714,GO:0005634,GO:0005739,GO:0006351,GO:0006357,GO:0006694,GO:0007028,GO:0007431,GO:0007565,GO:0008340,GO:0016020,GO:0043565,GO:0045927 negative regulation of transcription from RNA polymerase II promoter|cell morphogenesis|RNA polymerase II regulatory region sequence-specific DNA binding|fibrillar center|epithelial cell maturation|DNA binding transcription factor activity|transcription corepressor activity|nucleus|mitochondrion|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|steroid biosynthetic process|cytoplasm organization|salivary gland development|female pregnancy|determination of adult lifespan|membrane|sequence-specific DNA binding|positive regulation of growth TFDP1 3709.93405648615 3626.55832197829 3793.30979099402 1.04598063900011 0.0648561476871137 0.636639484995524 1 44.5414 44.6791 49.5893 43.8609 GeneID:7027,Genbank:XM_017020721.1,HGNC:HGNC:11749,MIM:189902 transcription factor Dp-1 hsa04110,hsa04350 Cell cycle|TGF-beta signaling pathway TFDP2 775.346875984675 753.955709571881 796.738042397468 1.05674382763131 0.0796256857098852 0.611817640373353 1 2.47796 2.28793 2.50955 2.47873 GeneID:7029,Genbank:NM_001178139.1,HGNC:HGNC:11751,MIM:602160 transcription factor Dp-2 hsa04110 Cell cycle TFE3 1972.95557202151 1956.55097264794 1989.36017139508 1.0167688954726 0.0239918018659989 0.878803114791551 1 18.1543 18.6715 18.8536 18.916 GeneID:7030,Genbank:NM_001282142.1,HGNC:HGNC:11752,MIM:314310 transcription factor binding to IGHM enhancer 3 hsa04137,hsa05202,hsa05211 Mitophagy - animal|Transcriptional misregulation in cancer|Renal cell carcinoma TFEB 145.463947489881 133.911920246489 157.015974733272 1.17253172416806 0.229626957009974 0.373993616027916 1 1.50586 1.40957 1.63191 1.72724 GeneID:7942,Genbank:NM_001167827.2,HGNC:HGNC:11753,MIM:600744 transcription factor EB hsa04137 Mitophagy - animal TFG 2479.03764514686 2531.62284585198 2426.45244444174 0.958457318560479 -0.061213906783351 0.664142971784449 1 39.0129 38.7918 37.7714 39.1967 GeneID:10342,Genbank:NM_001007565.2,HGNC:HGNC:11758,MIM:602498 TRK-fused gene hsa05200,hsa05216 Pathways in cancer|Thyroid cancer TFIP11 1031.35855497379 1032.4562767043 1030.26083324329 0.997873572459634 -0.00307105281136279 0.975318414394545 1 5.86592 6.24961 5.8778 6.50929 GeneID:24144,Genbank:NM_001346861.1,HGNC:HGNC:17165,MIM:612747 tuftelin interacting protein 11 GO:0000390,GO:0000398,GO:0000784,GO:0003677,GO:0005578,GO:0005654,GO:0005681,GO:0005730,GO:0005737,GO:0006355,GO:0006396,GO:0016607,GO:0031214,GO:0031333,GO:0031848,GO:0032091,GO:0071008,GO:0071013,GO:1904876,GO:2001033 spliceosomal complex disassembly|mRNA splicing, via spliceosome|nuclear chromosome, telomeric region|DNA binding|proteinaceous extracellular matrix|nucleoplasm|spliceosomal complex|nucleolus|cytoplasm|regulation of transcription, DNA-templated|RNA processing|nuclear speck|biomineral tissue development|negative regulation of protein complex assembly|protection from non-homologous end joining at telomere|negative regulation of protein binding|U2-type post-mRNA release spliceosomal complex|catalytic step 2 spliceosome|negative regulation of DNA ligase activity|negative regulation of double-strand break repair via nonhomologous end joining TFPI 187.994136800571 212.167423078795 163.820850522347 0.772130085500954 -0.373084167216598 0.282895104938643 1 1.4612 1.02617 1.08537 0.772212 GeneID:7035,Genbank:NM_006287.5,HGNC:HGNC:11760,MIM:152310 tissue factor pathway inhibitor hsa04610 Complement and coagulation cascades TFPI2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.019509 GeneID:7980,Genbank:NM_001271003.1,HGNC:HGNC:11761,MIM:600033 tissue factor pathway inhibitor 2 GO:0004867,GO:0005201,GO:0005578,GO:0007596,GO:0031012,GO:0071498 serine-type endopeptidase inhibitor activity|extracellular matrix structural constituent|proteinaceous extracellular matrix|blood coagulation|extracellular matrix|cellular response to fluid shear stress TFPT 464.567657037874 490.58174631695 438.553567758797 0.893945955085456 -0.16174048124953 0.352318696549002 1 8.19879 9.46211 7.43682 8.99921 GeneID:29844,Genbank:NM_013342.3,HGNC:HGNC:13630,MIM:609519 TCF3 fusion partner TFR2 4.42767195755156 3.52655236307142 5.32879155203169 1.51104846984056 0.595549938515367 0.757717232593899 1 0 0.0122192 0.0392419 0.0367657 GeneID:7036,Genbank:XM_005250553.4,HGNC:HGNC:11762,MIM:604720 transferrin receptor 2 GO:0004998,GO:0005886,GO:0005887,GO:0006826,GO:0006879,GO:0006898,GO:0006953,GO:0009897,GO:0010039,GO:0031410,GO:0033570,GO:0033572,GO:0039706,GO:0045807,GO:0045944,GO:0055072,GO:0071281,GO:0090277,GO:0098707,GO:1903319,GO:1990712 transferrin receptor activity|plasma membrane|integral component of plasma membrane|iron ion transport|cellular iron ion homeostasis|receptor-mediated endocytosis|acute-phase response|external side of plasma membrane|response to iron ion|cytoplasmic vesicle|transferrin transmembrane transporter activity|transferrin transport|co-receptor binding|positive regulation of endocytosis|positive regulation of transcription from RNA polymerase II promoter|iron ion homeostasis|cellular response to iron ion|positive regulation of peptide hormone secretion|ferrous iron import across plasma membrane|positive regulation of protein maturation|HFE-transferrin receptor complex TFRC 15744.0119124937 14992.8886553033 16495.1351696841 1.10019727011375 0.1377622283847 0.354224893515578 1 86.1262 78.576 101.828 80.7915 GeneID:7037,Genbank:XM_024453732.1,HGNC:HGNC:11763,MIM:190010 transferrin receptor hsa04066,hsa04144,hsa04145,hsa04216,hsa04640 HIF-1 signaling pathway|Endocytosis|Phagosome|Ferroptosis|Hematopoietic cell lineage TG 2.04752855006395 2.64246210852658 1.45259499160132 0.549712704267035 -0.863250273377329 0.823939110949976 1 0.00718237 0.00326833 0 0.00949502 GeneID:7038,Genbank:XM_017013794.1,HGNC:HGNC:11764,MIM:188450 thyroglobulin hsa04918,hsa05320 Thyroid hormone synthesis|Autoimmune thyroid disease TGDS 155.053266447289 166.159563225451 143.946969669127 0.866317694118007 -0.207031910953424 0.433006443083288 1 2.99083 2.62167 2.70105 2.26087 GeneID:23483,Genbank:NM_014305.3,HGNC:HGNC:20324,MIM:616146 TDP-glucose 4,6-dehydratase GO:0008460 dTDP-glucose 4,6-dehydratase activity TGFA 2002.00144597828 1635.02998334775 2368.97290860882 1.44888652363323 0.534944607867679 0.000142020939081017 0.0284325920040196 14.4562 14.5542 22.9161 19.6282 GeneID:7039,Genbank:NM_001099691.2,HGNC:HGNC:11765,MIM:190170 transforming growth factor alpha GO:0000139,GO:0000187,GO:0005154,GO:0005615,GO:0005789,GO:0005886,GO:0005887,GO:0006357,GO:0006888,GO:0008083,GO:0008283,GO:0009986,GO:0012507,GO:0016323,GO:0031410,GO:0033116,GO:0045741,GO:0045840,GO:0048208,GO:0048471,GO:0050679,GO:0051781 Golgi membrane|activation of MAPK activity|epidermal growth factor receptor binding|extracellular space|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|regulation of transcription from RNA polymerase II promoter|ER to Golgi vesicle-mediated transport|growth factor activity|cell proliferation|cell surface|ER to Golgi transport vesicle membrane|basolateral plasma membrane|cytoplasmic vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|positive regulation of epidermal growth factor-activated receptor activity|positive regulation of mitotic nuclear division|COPII vesicle coating|perinuclear region of cytoplasm|positive regulation of epithelial cell proliferation|positive regulation of cell division hsa01521,hsa04010,hsa04012,hsa04014,hsa04151,hsa04915,hsa05200,hsa05210,hsa05211,hsa05212,hsa05214,hsa05215,hsa05223,hsa05225 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|ErbB signaling pathway|Ras signaling pathway|PI3K-Akt signaling pathway|Estrogen signaling pathway|Pathways in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Glioma|Prostate cancer|Non-small cell lung cancer|Hepatocellular carcinoma TGFB1 4206.65555404439 3948.04414466146 4465.26696342732 1.13100735448089 0.177608310617395 0.198809989129543 1 47.9354 52.9023 59.1793 58.164 GeneID:7040,Genbank:NM_000660.6,HGNC:HGNC:11766,MIM:190180 transforming growth factor beta 1 hsa04010,hsa04060,hsa04068,hsa04110,hsa04218,hsa04350,hsa04380,hsa04390,hsa04659,hsa04672,hsa04926,hsa04932,hsa04933,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05166,hsa05200,hsa05205,hsa05210,hsa05211,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321,hsa05323,hsa05410,hsa05414 MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Cell cycle|Cellular senescence|TGF-beta signaling pathway|Osteoclast differentiation|Hippo signaling pathway|Th17 cell differentiation|Intestinal immune network for IgA production|Relaxin signaling pathway|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis|Chagas disease (American trypanosomiasis)|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease (IBD)|Rheumatoid arthritis|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) TGFB1I1 570.818211983899 609.02310410976 532.613319858038 0.874537133753877 -0.193408451111875 0.245649248362351 1 13.5993 14.4353 13.4885 12.1554 GeneID:7041,Genbank:NM_001042454.2,HGNC:HGNC:11767,MIM:602353 transforming growth factor beta 1 induced transcript 1 TGFB2 833.147895479737 857.367533037428 808.928257922046 0.943502321642884 -0.0839020270684725 0.684659900628882 1 6.20011 5.41844 6.22414 4.82679 GeneID:7042,Genbank:NM_001135599.3,HGNC:HGNC:11768,MIM:190220 transforming growth factor beta 2 GO:0000902,GO:0001501,GO:0001502,GO:0001540,GO:0001558,GO:0001568,GO:0001654,GO:0001666,GO:0001822,GO:0001837,GO:0001843,GO:0001942,GO:0001974,GO:0003007,GO:0003148,GO:0003149,GO:0003179,GO:0003181,GO:0003184,GO:0003203,GO:0003215,GO:0003222,GO:0003274,GO:0003289,GO:0003407,GO:0005102,GO:0005114,GO:0005125,GO:0005160,GO:0005576,GO:0005604,GO:0005615,GO:0005737,GO:0005768,GO:0005802,GO:0006468,GO:0007050,GO:0007179,GO:0007184,GO:0007411,GO:0007435,GO:0007507,GO:0007519,GO:0007565,GO:0007568,GO:0008083,GO:0008219,GO:0008284,GO:0008285,GO:0008347,GO:0008584,GO:0009314,GO:0009409,GO:0009611,GO:0009986,GO:0010002,GO:0010243,GO:0010628,GO:0010629,GO:0010634,GO:0010693,GO:0010718,GO:0010862,GO:0010936,GO:0014068,GO:0016049,GO:0016477,GO:0016525,GO:0023014,GO:0030097,GO:0030141,GO:0030198,GO:0030199,GO:0030307,GO:0030308,GO:0030324,GO:0030326,GO:0030335,GO:0030424,GO:0030509,GO:0030593,GO:0030878,GO:0030902,GO:0031012,GO:0031016,GO:0031069,GO:0032147,GO:0032355,GO:0032526,GO:0032570,GO:0032874,GO:0032909,GO:0032956,GO:0033280,GO:0033630,GO:0034097,GO:0034616,GO:0034714,GO:0035910,GO:0042060,GO:0042127,GO:0042416,GO:0042493,GO:0042637,GO:0042803,GO:0042981,GO:0043025,GO:0043065,GO:0043066,GO:0043408,GO:0043525,GO:0043627,GO:0045216,GO:0045726,GO:0045747,GO:0045778,GO:0045787,GO:0045823,GO:0046580,GO:0046982,GO:0047485,GO:0048103,GO:0048468,GO:0048565,GO:0048566,GO:0048663,GO:0048666,GO:0048702,GO:0048839,GO:0050680,GO:0050714,GO:0050777,GO:0050778,GO:0051280,GO:0051781,GO:0051795,GO:0051891,GO:0060021,GO:0060038,GO:0060065,GO:0060317,GO:0060325,GO:0060364,GO:0060389,GO:0060395,GO:0060412,GO:0060413,GO:0061037,GO:0061626,GO:0070237,GO:0090091,GO:0097191,GO:1900182,GO:1902256,GO:1902895,GO:1903053,GO:1903701,GO:1904426,GO:1904888,GO:1905006,GO:1905007,GO:2001241 cell morphogenesis|skeletal system development|cartilage condensation|amyloid-beta binding|regulation of cell growth|blood vessel development|eye development|response to hypoxia|kidney development|epithelial to mesenchymal transition|neural tube closure|hair follicle development|blood vessel remodeling|heart morphogenesis|outflow tract septum morphogenesis|membranous septum morphogenesis|heart valve morphogenesis|atrioventricular valve morphogenesis|pulmonary valve morphogenesis|endocardial cushion morphogenesis|cardiac right ventricle morphogenesis|ventricular trabecula myocardium morphogenesis|endocardial cushion fusion|atrial septum primum morphogenesis|neural retina development|receptor binding|type II transforming growth factor beta receptor binding|cytokine activity|transforming growth factor beta receptor binding|extracellular region|basement membrane|extracellular space|cytoplasm|endosome|trans-Golgi network|protein phosphorylation|cell cycle arrest|transforming growth factor beta receptor signaling pathway|SMAD protein import into nucleus|axon guidance|salivary gland morphogenesis|heart development|skeletal muscle tissue development|female pregnancy|aging|growth factor activity|cell death|positive regulation of cell proliferation|negative regulation of cell proliferation|glial cell migration|male gonad development|response to radiation|response to cold|response to wounding|cell surface|cardioblast differentiation|response to organonitrogen compound|positive regulation of gene expression|negative regulation of gene expression|positive regulation of epithelial cell migration|negative regulation of alkaline phosphatase activity|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of macrophage cytokine production|positive regulation of phosphatidylinositol 3-kinase signaling|cell growth|cell migration|negative regulation of angiogenesis|signal transduction by protein phosphorylation|hemopoiesis|secretory granule|extracellular matrix organization|collagen fibril organization|positive regulation of cell growth|negative regulation of cell growth|lung development|embryonic limb morphogenesis|positive regulation of cell migration|axon|BMP signaling pathway|neutrophil chemotaxis|thyroid gland development|hindbrain development|extracellular matrix|pancreas development|hair follicle morphogenesis|activation of protein kinase activity|response to estradiol|response to retinoic acid|response to progesterone|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor beta2 production|regulation of actin cytoskeleton organization|response to vitamin D|positive regulation of cell adhesion mediated by integrin|response to cytokine|response to laminar fluid shear stress|type III transforming growth factor beta receptor binding|ascending aorta morphogenesis|wound healing|regulation of cell proliferation|dopamine biosynthetic process|response to drug|catagen|protein homodimerization activity|regulation of apoptotic process|neuronal cell body|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of MAPK cascade|positive regulation of neuron apoptotic process|response to estrogen|cell-cell junction organization|positive regulation of integrin biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of ossification|positive regulation of cell cycle|positive regulation of heart contraction|negative regulation of Ras protein signal transduction|protein heterodimerization activity|protein N-terminus binding|somatic stem cell division|cell development|digestive tract development|embryonic digestive tract development|neuron fate commitment|neuron development|embryonic neurocranium morphogenesis|inner ear development|negative regulation of epithelial cell proliferation|positive regulation of protein secretion|negative regulation of immune response|positive regulation of immune response|negative regulation of release of sequestered calcium ion into cytosol|positive regulation of cell division|positive regulation of timing of catagen|positive regulation of cardioblast differentiation|palate development|cardiac muscle cell proliferation|uterus development|cardiac epithelial to mesenchymal transition|face morphogenesis|frontal suture morphogenesis|pathway-restricted SMAD protein phosphorylation|SMAD protein signal transduction|ventricular septum morphogenesis|atrial septum morphogenesis|negative regulation of cartilage development|pharyngeal arch artery morphogenesis|positive regulation of activation-induced cell death of T cells|positive regulation of extracellular matrix disassembly|extrinsic apoptotic signaling pathway|positive regulation of protein localization to nucleus|regulation of apoptotic process involved in outflow tract morphogenesis|positive regulation of pri-miRNA transcription from RNA polymerase II promoter|regulation of extracellular matrix organization|substantia propria of cornea development|positive regulation of GTP binding|cranial skeletal system development|negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa04010,hsa04060,hsa04068,hsa04110,hsa04218,hsa04350,hsa04380,hsa04390,hsa04933,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05166,hsa05200,hsa05205,hsa05206,hsa05210,hsa05211,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321,hsa05323,hsa05410,hsa05414 MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Cell cycle|Cellular senescence|TGF-beta signaling pathway|Osteoclast differentiation|Hippo signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis|Chagas disease (American trypanosomiasis)|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease (IBD)|Rheumatoid arthritis|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) TGFB3 211.38847421462 179.487543627669 243.28940480157 1.35546679108971 0.43878976760787 0.0481335022086281 0.805544588686926 1.54583 1.39198 2.08743 1.94831 GeneID:7043,Genbank:NM_001329939.1,HGNC:HGNC:11769,MIM:190230 transforming growth factor beta 3 hsa04010,hsa04060,hsa04068,hsa04110,hsa04218,hsa04350,hsa04390,hsa04933,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05166,hsa05200,hsa05210,hsa05211,hsa05212,hsa05220,hsa05225,hsa05226,hsa05321,hsa05323,hsa05410,hsa05414 MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Cell cycle|Cellular senescence|TGF-beta signaling pathway|Hippo signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Leishmaniasis|Chagas disease (American trypanosomiasis)|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Renal cell carcinoma|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer|Inflammatory bowel disease (IBD)|Rheumatoid arthritis|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) TGFBI 10306.2181889451 11011.0380812671 9601.39829662324 0.871979392475082 -0.197634054753637 0.134791469255015 1 142.14 128.421 114.758 123.96 GeneID:7045,Genbank:NM_000358.2,HGNC:HGNC:11771,MIM:601692 transforming growth factor beta induced TGFBR1 283.979870309281 285.869221470284 282.090519148277 0.986781709823209 -0.019197119614037 0.963048909782342 1 1.34468 1.1938 1.46091 1.06547 GeneID:7046,Genbank:XM_011518949.2,HGNC:HGNC:11772,MIM:190181 transforming growth factor beta receptor 1 GO:0000186,GO:0001501,GO:0001525,GO:0001701,GO:0001822,GO:0001824,GO:0001837,GO:0001937,GO:0001938,GO:0002088,GO:0003222,GO:0003223,GO:0004672,GO:0004674,GO:0004702,GO:0005024,GO:0005025,GO:0005057,GO:0005102,GO:0005114,GO:0005524,GO:0005622,GO:0005623,GO:0005768,GO:0005886,GO:0005901,GO:0005923,GO:0006355,GO:0006468,GO:0006915,GO:0007165,GO:0007179,GO:0007507,GO:0008284,GO:0008354,GO:0008584,GO:0009791,GO:0009952,GO:0009986,GO:0010468,GO:0010628,GO:0010717,GO:0010718,GO:0010862,GO:0016020,GO:0016021,GO:0018105,GO:0018107,GO:0030199,GO:0030307,GO:0030335,GO:0031396,GO:0032331,GO:0032924,GO:0035556,GO:0042118,GO:0043065,GO:0043066,GO:0043231,GO:0043235,GO:0043393,GO:0043542,GO:0045121,GO:0045893,GO:0046332,GO:0046872,GO:0048538,GO:0048663,GO:0048701,GO:0048705,GO:0048762,GO:0048844,GO:0048870,GO:0050431,GO:0051272,GO:0051491,GO:0051496,GO:0051897,GO:0060017,GO:0060021,GO:0060037,GO:0060043,GO:0060317,GO:0060389,GO:0060391,GO:0060412,GO:0060978,GO:0060982,GO:0070411,GO:0070723,GO:0071560,GO:1905007,GO:1905075,GO:1905223,GO:2001235,GO:2001237 activation of MAPKK activity|skeletal system development|angiogenesis|in utero embryonic development|kidney development|blastocyst development|epithelial to mesenchymal transition|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|lens development in camera-type eye|ventricular trabecula myocardium morphogenesis|ventricular compact myocardium morphogenesis|protein kinase activity|protein serine/threonine kinase activity|signal transducer, downstream of receptor, with serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|transforming growth factor beta receptor activity, type I|signal transducer activity, downstream of receptor|receptor binding|type II transforming growth factor beta receptor binding|ATP binding|intracellular|cell|endosome|plasma membrane|caveola|bicellular tight junction|regulation of transcription, DNA-templated|protein phosphorylation|apoptotic process|signal transduction|transforming growth factor beta receptor signaling pathway|heart development|positive regulation of cell proliferation|germ cell migration|male gonad development|post-embryonic development|anterior/posterior pattern specification|cell surface|regulation of gene expression|positive regulation of gene expression|regulation of epithelial to mesenchymal transition|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|membrane|integral component of membrane|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|collagen fibril organization|positive regulation of cell growth|positive regulation of cell migration|regulation of protein ubiquitination|negative regulation of chondrocyte differentiation|activin receptor signaling pathway|intracellular signal transduction|endothelial cell activation|positive regulation of apoptotic process|negative regulation of apoptotic process|intracellular membrane-bounded organelle|receptor complex|regulation of protein binding|endothelial cell migration|membrane raft|positive regulation of transcription, DNA-templated|SMAD binding|metal ion binding|thymus development|neuron fate commitment|embryonic cranial skeleton morphogenesis|skeletal system morphogenesis|mesenchymal cell differentiation|artery morphogenesis|cell motility|transforming growth factor beta binding|positive regulation of cellular component movement|positive regulation of filopodium assembly|positive regulation of stress fiber assembly|positive regulation of protein kinase B signaling|parathyroid gland development|palate development|pharyngeal system development|regulation of cardiac muscle cell proliferation|cardiac epithelial to mesenchymal transition|pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|ventricular septum morphogenesis|angiogenesis involved in coronary vascular morphogenesis|coronary artery morphogenesis|I-SMAD binding|response to cholesterol|cellular response to transforming growth factor beta stimulus|positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation|positive regulation of occluding junction disassembly|epicardium morphogenesis|positive regulation of apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway hsa04010,hsa04060,hsa04068,hsa04144,hsa04218,hsa04350,hsa04371,hsa04380,hsa04390,hsa04520,hsa04659,hsa04926,hsa04933,hsa05142,hsa05161,hsa05166,hsa05200,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226 MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Endocytosis|Cellular senescence|TGF-beta signaling pathway|Apelin signaling pathway|Osteoclast differentiation|Hippo signaling pathway|Adherens junction|Th17 cell differentiation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Chagas disease (American trypanosomiasis)|Hepatitis B|Human T-cell leukemia virus 1 infection|Pathways in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer TGFBR2 2347.54935187925 2490.72538842546 2204.37331533304 0.885032659793364 -0.176197399858363 0.366143349034653 1 15.3736 14.4873 15.6214 11.3284 GeneID:7048,Genbank:XM_011534045.3,HGNC:HGNC:11773,MIM:190182 transforming growth factor beta receptor 2 hsa04010,hsa04060,hsa04068,hsa04144,hsa04218,hsa04350,hsa04380,hsa04390,hsa04520,hsa04659,hsa04926,hsa04933,hsa05142,hsa05166,hsa05200,hsa05202,hsa05210,hsa05212,hsa05220,hsa05225,hsa05226 MAPK signaling pathway|Cytokine-cytokine receptor interaction|FoxO signaling pathway|Endocytosis|Cellular senescence|TGF-beta signaling pathway|Osteoclast differentiation|Hippo signaling pathway|Adherens junction|Th17 cell differentiation|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Chagas disease (American trypanosomiasis)|Human T-cell leukemia virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Colorectal cancer|Pancreatic cancer|Chronic myeloid leukemia|Hepatocellular carcinoma|Gastric cancer TGFBR3 49.4092146396685 51.8024727825708 47.0159564967662 0.907600621578531 -0.139870497833968 0.751131378067516 1 0.300162 0.319523 0.305497 0.215054 GeneID:7049,Genbank:NM_001195684.1,HGNC:HGNC:11774,MIM:600742 transforming growth factor beta receptor 3 TGFBR3L 10.3673847046849 8.61937148138481 12.1153979279851 1.40560108752136 0.491187212680516 0.631990612729531 1 0.0754241 0.106359 0.0690775 0.214825 GeneID:100507588,Genbank:XM_011527611.2,HGNC:HGNC:44152 transforming growth factor beta receptor 3 like GO:0016021 integral component of membrane TGFBRAP1 989.47854368183 1006.30019595693 972.656891406733 0.966567327835804 -0.049057865656488 0.742634487220915 1 5.43686 5.91585 5.69505 5.15349 GeneID:9392,Genbank:NM_001328646.1,HGNC:HGNC:16836,MIM:606237 transforming growth factor beta receptor associated protein 1 TGIF1 1061.54788440152 1137.34812303083 985.747645772213 0.866707058121637 -0.206383641474453 0.173052032487267 1 10.2197 9.72076 8.86142 8.89458 GeneID:7050,Genbank:NM_174886.2,HGNC:HGNC:11776,MIM:602630 TGFB induced factor homeobox 1 GO:0000122,GO:0000978,GO:0001078,GO:0003700,GO:0003714,GO:0005654,GO:0006351,GO:0007275,GO:0042493,GO:0070410,GO:0071363 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleoplasm|transcription, DNA-templated|multicellular organism development|response to drug|co-SMAD binding|cellular response to growth factor stimulus hsa04350 TGF-beta signaling pathway TGIF2 591.800856094579 621.898213728743 561.703498460414 0.903208091067802 -0.14686968484918 0.392909819217641 1 8.76325 7.979 8.20379 7.24538 GeneID:60436,Genbank:NM_001199514.1,HGNC:HGNC:15764,MIM:607294 TGFB induced factor homeobox 2 GO:0000122,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0010470,GO:0038092,GO:0045666,GO:0060041 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of gastrulation|nodal signaling pathway|positive regulation of neuron differentiation|retina development in camera-type eye hsa04350 TGF-beta signaling pathway TGM1 6.17757041860839 4.60274771635603 7.75239312086075 1.68429677197217 0.75214636270972 0.571013325996285 1 0.030104 0.0524701 0.0701366 0.117704 GeneID:7051,Genbank:NM_000359.2,HGNC:HGNC:11777,MIM:190195 transglutaminase 1 TGM2 17.7700510741013 25.8483057890465 9.69179635915603 0.374948998137551 -1.41523372631382 0.0410474756411386 0.759435523043776 0.180801 0.132627 0.0514134 0.0687142 GeneID:7052,Genbank:NM_001323316.1,HGNC:HGNC:11778,MIM:190196 transglutaminase 2 hsa05016 Huntington disease TGM4 6.97081836144485 7.63922867747008 6.30240804541962 0.825005810338802 -0.277523814901688 0.856405293398086 1 0.0344442 0.09455 0.0762048 0.0406061 GeneID:7047,Genbank:NM_003241.3,HGNC:HGNC:11780,MIM:600585 transglutaminase 4 GO:0003810,GO:0005737,GO:0005794,GO:0018149,GO:0031012,GO:0046872,GO:0070062 protein-glutamine gamma-glutamyltransferase activity|cytoplasm|Golgi apparatus|peptide cross-linking|extracellular matrix|metal ion binding|extracellular exosome TGM5 88.2273004168446 88.7303157178968 87.7242851157924 0.988661929195621 -0.0164508160193338 0.95562834036972 1 0.709875 0.749795 0.774958 0.733652 GeneID:9333,Genbank:NM_004245.3,HGNC:HGNC:11781,MIM:603805 transglutaminase 5 GO:0003810,GO:0005737,GO:0005886,GO:0006464,GO:0008544,GO:0018149,GO:0046872,GO:0070268 protein-glutamine gamma-glutamyltransferase activity|cytoplasm|plasma membrane|cellular protein modification process|epidermis development|peptide cross-linking|metal ion binding|cornification TGOLN2 5432.29997804656 4700.10990185954 6164.49005423358 1.31156295979264 0.391287063874684 0.00310913674448991 0.209226613864497 31.479 31.1678 46.2557 36.8841 GeneID:10618,Genbank:NM_001206844.1,HGNC:HGNC:15450,MIM:603062 trans-golgi network protein 2 GO:0005654,GO:0005768,GO:0005788,GO:0005794,GO:0005802,GO:0005829,GO:0005886,GO:0006895,GO:0016021,GO:0030133,GO:0030140,GO:0030665,GO:0043687,GO:0044267,GO:0061024 nucleoplasm|endosome|endoplasmic reticulum lumen|Golgi apparatus|trans-Golgi network|cytosol|plasma membrane|Golgi to endosome transport|integral component of membrane|transport vesicle|trans-Golgi network transport vesicle|clathrin-coated vesicle membrane|post-translational protein modification|cellular protein metabolic process|membrane organization TGS1 470.71653720171 517.821797071005 423.611277332415 0.818063819886532 -0.289714697878933 0.231870998178674 1 4.14758 3.49222 3.55757 2.68968 GeneID:96764,Genbank:NM_024831.7,HGNC:HGNC:17843,MIM:606461 trimethylguanosine synthase 1 GO:0000387,GO:0005615,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0008173,GO:0009452,GO:0015030,GO:0019216,GO:0022613,GO:0030532,GO:0036261,GO:0071164,GO:0071167 spliceosomal snRNP assembly|extracellular space|nucleus|nucleoplasm|nucleolus|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA methyltransferase activity|7-methylguanosine RNA capping|Cajal body|regulation of lipid metabolic process|ribonucleoprotein complex biogenesis|small nuclear ribonucleoprotein complex|7-methylguanosine cap hypermethylation|RNA trimethylguanosine synthase activity|ribonucleoprotein complex import into nucleus hsa03013 RNA transport TH 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0 0 0 GeneID:7054,Genbank:XM_011520335.2,HGNC:HGNC:11782,MIM:191290 tyrosine hydroxylase hsa00350,hsa00790,hsa04728,hsa04917,hsa05012,hsa05030,hsa05031,hsa05034 Tyrosine metabolism|Folate biosynthesis|Dopaminergic synapse|Prolactin signaling pathway|Parkinson disease|Cocaine addiction|Amphetamine addiction|Alcoholism THADA 503.94761196621 545.06388182677 462.831342105651 0.849132289878539 -0.235938760091395 0.185151658066376 1 2.89095 2.36911 2.35096 2.11921 GeneID:63892,Genbank:NM_001345924.1,HGNC:HGNC:19217,MIM:611800 THADA, armadillo repeat containing GO:0032471,GO:0055088,GO:0098554,GO:1901895,GO:1990845 negative regulation of endoplasmic reticulum calcium ion concentration|lipid homeostasis|cytoplasmic side of endoplasmic reticulum membrane|negative regulation of calcium-transporting ATPase activity|adaptive thermogenesis THAP1 232.703623849532 251.680910193709 213.726337505355 0.849195663432946 -0.235831091001299 0.269725615147131 1 4.59768 5.50976 4.54699 4.07356 GeneID:55145,Genbank:NM_199003.1,HGNC:HGNC:20856,MIM:609520 THAP domain containing 1 GO:0000122,GO:0000978,GO:0001078,GO:0001650,GO:0001935,GO:0005634,GO:0006351,GO:0006355,GO:0007049,GO:0007346,GO:0008270,GO:0016605,GO:0042802,GO:0042803,GO:0043231,GO:0043565 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|fibrillar center|endothelial cell proliferation|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|regulation of mitotic cell cycle|zinc ion binding|PML body|identical protein binding|protein homodimerization activity|intracellular membrane-bounded organelle|sequence-specific DNA binding THAP10 174.80154233997 186.752370762768 162.850713917173 0.872014171772109 -0.197576513349376 0.403904828899483 1 4.17621 4.72907 4.39053 3.24908 GeneID:56906,Genbank:NM_020147.3,HGNC:HGNC:23193,MIM:612538 THAP domain containing 10 GO:0003677,GO:0046872 DNA binding|metal ion binding THAP11 983.791151863884 1024.54850768893 943.033796038833 0.920438406733934 -0.11960691135953 0.420020387967448 1 31.3528 33.6867 28.7651 31.7735 GeneID:57215,Genbank:NM_020457.2,HGNC:HGNC:23194,MIM:609119 THAP domain containing 11 GO:0000122,GO:0000978,GO:0001078,GO:0003677,GO:0005654,GO:0005737,GO:0006351,GO:0008270,GO:0045171 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|transcription, DNA-templated|zinc ion binding|intercellular bridge THAP12 602.579837107285 615.796842842046 589.362831372523 0.95707348652922 -0.0632983921395059 0.711160540833343 1 6.14674 6.3539 6.92802 5.31687 GeneID:5612,Genbank:NM_004705.3,HGNC:HGNC:9440,MIM:607374 THAP domain containing 12 GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0006950,GO:0007165,GO:0008285,GO:0046872,GO:0046983 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|response to stress|signal transduction|negative regulation of cell proliferation|metal ion binding|protein dimerization activity THAP2 42.3289693199108 47.824066637119 36.8338720027026 0.770195313631353 -0.376703750019635 0.469094511361556 1 0.538265 0.357791 0.382019 0.281234 GeneID:83591,Genbank:NM_031435.3,HGNC:HGNC:20854,MIM:612531 THAP domain containing 2 GO:0003677,GO:0005730,GO:0046872 DNA binding|nucleolus|metal ion binding THAP3 516.621239803499 520.561328729757 512.681150877241 0.984862152800047 -0.0220062844185966 0.919280686391958 1 4.44473 4.3063 4.02254 4.59194 GeneID:90326,Genbank:XM_024450686.1,HGNC:HGNC:20855,MIM:612532 THAP domain containing 3 GO:0003677,GO:0046872 DNA binding|metal ion binding THAP4 1287.1462705058 1288.53903786137 1285.75350315024 0.997838222491299 -0.00312216161790172 0.957069518951815 1 15.4687 16.9048 18.0811 15.6673 GeneID:51078,Genbank:XM_005247016.4,HGNC:HGNC:23187,MIM:612533 THAP domain containing 4 GO:0003677,GO:0020037,GO:0042803,GO:0046872 DNA binding|heme binding|protein homodimerization activity|metal ion binding THAP5 252.163903946997 259.0789904969 245.248817397094 0.946617928866865 -0.0791458480251525 0.786282248869105 1 2.83206 2.42773 2.90514 2.17227 GeneID:168451,Genbank:NM_001287601.1,HGNC:HGNC:23188,MIM:612534 THAP domain containing 5 GO:0002020,GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0007049,GO:0045786,GO:0046872 protease binding|DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|negative regulation of cell cycle|metal ion binding THAP6 208.040358912229 207.190273820067 208.890444004391 1.00820583974806 0.0117902158883638 0.945594834821016 1 1.05201 0.869689 1.08457 0.850295 GeneID:152815,Genbank:XM_011531667.3,HGNC:HGNC:23189,MIM:612535 THAP domain containing 6 GO:0003677,GO:0015630,GO:0046872 DNA binding|microtubule cytoskeleton|metal ion binding THAP7 575.257958849179 589.833884194269 560.682033504089 0.95057616818674 -0.0731258624768594 0.651954848323608 1 17.3934 18.9712 17.2193 18.8145 GeneID:80764,Genbank:NM_001008695.1,HGNC:HGNC:23190,MIM:609518 THAP domain containing 7 GO:0003677,GO:0005634,GO:0005694,GO:0006351,GO:0016607,GO:0031965,GO:0042802,GO:0043231,GO:0045892,GO:0046872,GO:0047485,GO:0070742 DNA binding|nucleus|chromosome|transcription, DNA-templated|nuclear speck|nuclear membrane|identical protein binding|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated|metal ion binding|protein N-terminus binding|C2H2 zinc finger domain binding THAP8 185.434055350816 176.547115215925 194.320995485708 1.10067499685874 0.138388538259253 0.546778973354944 1 4.48553 3.53261 4.20618 4.75747 GeneID:199745,Genbank:NM_001331104.1,HGNC:HGNC:23191,MIM:612536 THAP domain containing 8 GO:0003677,GO:0046872 DNA binding|metal ion binding THAP9 18.9744426697408 19.0451410914363 18.9037442480453 0.992575699874725 -0.0107509597157202 1 1 0.167814 0.164613 0.182278 0.098037 GeneID:79725,Genbank:NM_001317776.1,HGNC:HGNC:23192,MIM:612537 THAP domain containing 9 GO:0004803,GO:0006310,GO:0006313,GO:0015074,GO:0016740,GO:0043565,GO:0046872 transposase activity|DNA recombination|transposition, DNA-mediated|DNA integration|transferase activity|sequence-specific DNA binding|metal ion binding THBS1 22045.9982675867 20899.7646928365 23192.2318423369 1.10968865837452 0.150154961238069 0.498767932411777 1 100.64 97.0705 131.824 91.9611 GeneID:7057,Genbank:NM_003246.3,HGNC:HGNC:11785,MIM:188060 thrombospondin 1 hsa04015,hsa04115,hsa04145,hsa04151,hsa04350,hsa04510,hsa04512,hsa05144,hsa05165,hsa05205,hsa05206,hsa05219 Rap1 signaling pathway|p53 signaling pathway|Phagosome|PI3K-Akt signaling pathway|TGF-beta signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection|Proteoglycans in cancer|MicroRNAs in cancer|Bladder cancer THBS2 1698.47026961551 1710.33830011577 1686.60223911525 0.986122008143702 -0.0201619395069647 0.870351607190618 1 9.4844 10.2741 10.819 9.19426 GeneID:7058,Genbank:NM_003247.3,HGNC:HGNC:11786,MIM:188061 thrombospondin 2 hsa04145,hsa04151,hsa04510,hsa04512,hsa05144,hsa05165 Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection THBS3 403.400785337863 362.435013034364 444.366557641363 1.22605858060195 0.294027912083243 0.113846656405216 1 1.55566 1.76645 2.02634 2.20241 GeneID:7059,Genbank:XM_011509935.1,HGNC:HGNC:11787,MIM:188062 thrombospondin 3 GO:0003417,GO:0005509,GO:0005576,GO:0007160,GO:0008201,GO:0030198,GO:0031012,GO:0043931,GO:0048471,GO:0060346 growth plate cartilage development|calcium ion binding|extracellular region|cell-matrix adhesion|heparin binding|extracellular matrix organization|extracellular matrix|ossification involved in bone maturation|perinuclear region of cytoplasm|bone trabecula formation hsa04145,hsa04151,hsa04510,hsa04512,hsa05144,hsa05165 Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection THBS4 17.5770165752796 11.8959838159236 23.2580493346356 1.95511776869629 0.967255512492635 0.155213338376407 1 0.0757343 0.0767701 0.0712609 0.173838 GeneID:7060,Genbank:NM_001306213.1,HGNC:HGNC:11788,MIM:600715 thrombospondin 4 hsa04145,hsa04151,hsa04510,hsa04512,hsa05144,hsa05165 Phagosome|PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Malaria|Human papillomavirus infection THEGL 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0.0117094 0.0110543 0 0 GeneID:100506564,Genbank:XM_011534357.1,HGNC:HGNC:43771 theg spermatid protein like THEM4 192.416568500049 222.988228542289 161.844908457809 0.725800234011528 -0.46235557291826 0.0434957455364049 0.780326589998453 1.27297 1.55029 0.932227 1.05392 GeneID:117145,Genbank:NM_053055.4,HGNC:HGNC:17947,MIM:606388 thioesterase superfamily member 4 GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0005829,GO:0005886,GO:0006631,GO:0006637,GO:0016290,GO:0032587,GO:0043491,GO:0047617,GO:0051898,GO:0102991,GO:1902108 mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|cytosol|plasma membrane|fatty acid metabolic process|acyl-CoA metabolic process|palmitoyl-CoA hydrolase activity|ruffle membrane|protein kinase B signaling|acyl-CoA hydrolase activity|negative regulation of protein kinase B signaling|myristoyl-CoA hydrolase activity|regulation of mitochondrial membrane permeability involved in apoptotic process hsa00062,hsa04151 Fatty acid elongation|PI3K-Akt signaling pathway THEM6 224.97875799507 228.484875168297 221.472640821842 0.969309853261444 -0.0449701781557584 0.816601580172137 1 5.68079 6.9565 6.47156 6.23521 GeneID:51337,Genbank:NM_016647.2,HGNC:HGNC:29656 thioesterase superfamily member 6 GO:0005576 extracellular region THEMIS2 8.60215032596594 4.11267631439867 13.0916243375332 3.18323722479662 1.67049467512804 0.236236921370836 1 0.0626933 0.0275561 0.291938 0.0819345 GeneID:9473,Genbank:XM_005246041.3,HGNC:HGNC:16839,MIM:617856 thymocyte selection associated family member 2 GO:0005634,GO:0005737,GO:0006954,GO:0007155,GO:0050852 nucleus|cytoplasm|inflammatory response|cell adhesion|T cell receptor signaling pathway THG1L 513.012561621958 534.639129217573 491.385994026342 0.919098448228938 -0.12170869238865 0.476706054401857 1 4.95449 5.47954 4.58319 5.03213 GeneID:54974,Genbank:NM_017872.4,HGNC:HGNC:26053 tRNA-histidine guanylyltransferase 1 like GO:0000049,GO:0000287,GO:0005524,GO:0005525,GO:0005739,GO:0005829,GO:0006400,GO:0008033,GO:0008193,GO:0016779,GO:0042802,GO:0051289 tRNA binding|magnesium ion binding|ATP binding|GTP binding|mitochondrion|cytosol|tRNA modification|tRNA processing|tRNA guanylyltransferase activity|nucleotidyltransferase activity|identical protein binding|protein homotetramerization THNSL1 62.8568650863606 66.1007873335962 59.6129428391249 0.901849210029396 -0.149041861105775 0.695758496521819 1 0.643007 0.678919 0.596963 0.525722 GeneID:79896,Genbank:XM_017016665.1,HGNC:HGNC:26160,MIM:611260 threonine synthase like 1 THOC1 331.789643015724 376.675492655596 286.903793375853 0.761673639432061 -0.392755128180031 0.0422574184559481 0.766472043024309 1.70126 2.00153 1.56084 1.44213 GeneID:9984,Genbank:XM_011525772.3,HGNC:HGNC:19070,MIM:606930 THO complex 1 GO:0000018,GO:0000346,GO:0000347,GO:0000445,GO:0003677,GO:0003723,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006369,GO:0006396,GO:0006405,GO:0006406,GO:0006915,GO:0007165,GO:0008380,GO:0016363,GO:0016607,GO:0031124,GO:0031297,GO:0032784,GO:0032786,GO:0045171,GO:0046784,GO:0048297,GO:2000002 regulation of DNA recombination|transcription export complex|THO complex|THO complex part of transcription export complex|DNA binding|RNA binding|nucleus|nucleoplasm|cytoplasm|cytosol|termination of RNA polymerase II transcription|RNA processing|RNA export from nucleus|mRNA export from nucleus|apoptotic process|signal transduction|RNA splicing|nuclear matrix|nuclear speck|mRNA 3'-end processing|replication fork processing|regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|intercellular bridge|viral mRNA export from host cell nucleus|negative regulation of isotype switching to IgA isotypes|negative regulation of DNA damage checkpoint hsa03013,hsa03040 RNA transport|Spliceosome THOC2 523.331003816947 532.868914706774 513.793092927119 0.964201661509657 -0.0525931791029229 0.91612139042596 1 1.96562 1.44423 2.0243 1.30954 GeneID:57187,Genbank:NM_001081550.1,HGNC:HGNC:19073,MIM:300395 THO complex 2 GO:0000346,GO:0000347,GO:0000445,GO:0003729,GO:0005654,GO:0006369,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0016973,GO:0031124,GO:0046784,GO:0048666,GO:0048699 transcription export complex|THO complex|THO complex part of transcription export complex|mRNA binding|nucleoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|viral mRNA export from host cell nucleus|neuron development|generation of neurons hsa03013,hsa03040 RNA transport|Spliceosome THOC3 1013.95090245525 1171.61693754997 856.284867360535 0.730857364652951 -0.452338220018341 0.0553284896182972 0.855410907895938 25.4425 32.3216 21.0886 22.3439 GeneID:84321,Genbank:XM_017009985.1,HGNC:HGNC:19072,MIM:606929 THO complex 3 GO:0000346,GO:0000445,GO:0003723,GO:0005654,GO:0006369,GO:0006405,GO:0006406,GO:0008380,GO:0016607,GO:0031124,GO:0046784 transcription export complex|THO complex part of transcription export complex|RNA binding|nucleoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|RNA splicing|nuclear speck|mRNA 3'-end processing|viral mRNA export from host cell nucleus hsa03013,hsa03040 RNA transport|Spliceosome THOC5 919.867941841311 867.103351493384 972.632532189238 1.12170311706685 0.165690886097035 0.291433339605463 1 6.53882 7.04696 7.665 7.31581 GeneID:8563,Genbank:XM_005261797.1,HGNC:HGNC:19074,MIM:612733 THO complex 5 GO:0000346,GO:0000347,GO:0000445,GO:0003729,GO:0005634,GO:0005654,GO:0005737,GO:0006369,GO:0006405,GO:0006406,GO:0008380,GO:0030224,GO:0031124,GO:0032786,GO:0046784,GO:0060215,GO:2000002 transcription export complex|THO complex|THO complex part of transcription export complex|mRNA binding|nucleus|nucleoplasm|cytoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|RNA splicing|monocyte differentiation|mRNA 3'-end processing|positive regulation of DNA-templated transcription, elongation|viral mRNA export from host cell nucleus|primitive hemopoiesis|negative regulation of DNA damage checkpoint hsa03013 RNA transport THOC6 686.40403835679 679.812883053974 692.995193659605 1.01939108677437 0.0277076439527111 0.878573093237229 1 20.9828 20.3863 21.7134 22.5616 GeneID:79228,Genbank:NM_024339.4,HGNC:HGNC:28369,MIM:615403 THO complex 6 GO:0000346,GO:0000347,GO:0000445,GO:0003723,GO:0005634,GO:0005654,GO:0006369,GO:0006405,GO:0006406,GO:0006915,GO:0007417,GO:0008380,GO:0016604,GO:0016607,GO:0031124,GO:0043066,GO:0046784 transcription export complex|THO complex|THO complex part of transcription export complex|RNA binding|nucleus|nucleoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|apoptotic process|central nervous system development|RNA splicing|nuclear body|nuclear speck|mRNA 3'-end processing|negative regulation of apoptotic process|viral mRNA export from host cell nucleus hsa03013 RNA transport THOC7 996.865182246125 968.746994449841 1024.98337004241 1.05805063232687 0.0814086683395069 0.587059423464735 1 27.0685 26.6711 30.0377 29.0983 GeneID:80145,Genbank:XM_006713339.3,HGNC:HGNC:29874,MIM:611965 THO complex 7 GO:0000445,GO:0000781,GO:0003723,GO:0005634,GO:0005737,GO:0006397,GO:0006406,GO:0008380,GO:0016607 THO complex part of transcription export complex|chromosome, telomeric region|RNA binding|nucleus|cytoplasm|mRNA processing|mRNA export from nucleus|RNA splicing|nuclear speck hsa03013 RNA transport THOP1 2738.25597351603 2718.18616251857 2758.32578451349 1.01476706141338 0.0211485964628593 0.90276410487715 1 19.9867 21.1822 20.1832 22.4042 GeneID:7064,Genbank:NM_003249.4,HGNC:HGNC:11793,MIM:601117 thimet oligopeptidase 1 GO:0000209,GO:0004222,GO:0005758,GO:0005829,GO:0006518,GO:0042277,GO:0046872 protein polyubiquitination|metalloendopeptidase activity|mitochondrial intermembrane space|cytosol|peptide metabolic process|peptide binding|metal ion binding hsa04614,hsa05143 Renin-angiotensin system|African trypanosomiasis THPO 1.21680388378472 0.980142803914724 1.45346496365472 1.48291142663041 0.568432429095832 1 1 0 0.0341668 0.0178375 0.0335384 GeneID:7066,Genbank:NM_001290028.1,HGNC:HGNC:11795,MIM:600044 thrombopoietin GO:0001934,GO:0005125,GO:0005179,GO:0005615,GO:0007275,GO:0008083,GO:0008283,GO:0030099,GO:0038163,GO:0045654,GO:0051897,GO:0070374,GO:1902035 positive regulation of protein phosphorylation|cytokine activity|hormone activity|extracellular space|multicellular organism development|growth factor activity|cell proliferation|myeloid cell differentiation|thrombopoietin-mediated signaling pathway|positive regulation of megakaryocyte differentiation|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade|positive regulation of hematopoietic stem cell proliferation hsa04060,hsa04630,hsa04640 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway|Hematopoietic cell lineage THRA 867.682666172412 826.216719722822 909.148612622003 1.10037547161597 0.13799588612227 0.385445851603727 1 7.77849 7.72136 8.38789 8.63102 GeneID:7067,Genbank:NM_001190919.1,HGNC:HGNC:11796,MIM:190120 thyroid hormone receptor alpha GO:0000976,GO:0001502,GO:0001503,GO:0002153,GO:0002155,GO:0003700,GO:0003707,GO:0004887,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006366,GO:0006367,GO:0007611,GO:0008016,GO:0008050,GO:0008134,GO:0008270,GO:0009409,GO:0009755,GO:0010831,GO:0017025,GO:0017055,GO:0019904,GO:0030218,GO:0030878,GO:0031490,GO:0032403,GO:0033032,GO:0042994,GO:0044212,GO:0045892,GO:0045925,GO:0045944,GO:0050994,GO:0060509,GO:0070324,GO:2000143 transcription regulatory region sequence-specific DNA binding|cartilage condensation|ossification|steroid receptor RNA activator RNA binding|regulation of thyroid hormone mediated signaling pathway|DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|nucleus|nucleoplasm|cytosol|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|learning or memory|regulation of heart contraction|female courtship behavior|transcription factor binding|zinc ion binding|response to cold|hormone-mediated signaling pathway|positive regulation of myotube differentiation|TBP-class protein binding|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|protein domain specific binding|erythrocyte differentiation|thyroid gland development|chromatin DNA binding|protein complex binding|regulation of myeloid cell apoptotic process|cytoplasmic sequestering of transcription factor|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|positive regulation of female receptivity|positive regulation of transcription from RNA polymerase II promoter|regulation of lipid catabolic process|Type I pneumocyte differentiation|thyroid hormone binding|negative regulation of DNA-templated transcription, initiation hsa04080,hsa04919 Neuroactive ligand-receptor interaction|Thyroid hormone signaling pathway THRAP3 5006.52686713984 5301.50256894609 4711.55116533359 0.888719962701108 -0.170199200092824 0.202452247671648 1 26.5794 26.8241 24.5931 23.334 GeneID:9967,Genbank:NM_001321471.1,HGNC:HGNC:22964,MIM:603809 thyroid hormone receptor associated protein 3 THRB 176.947762764744 158.079306421563 195.816219107926 1.23872139586523 0.308851743571327 0.390703793580899 1 0.449202 0.68462 0.81922 0.576958 GeneID:7068,Genbank:NM_001354708.1,HGNC:HGNC:11799,MIM:190160 thyroid hormone receptor beta GO:0000122,GO:0000790,GO:0003677,GO:0003700,GO:0003707,GO:0003714,GO:0004887,GO:0005634,GO:0005654,GO:0006351,GO:0006367,GO:0007605,GO:0007621,GO:0008016,GO:0008050,GO:0008270,GO:0009887,GO:0016604,GO:0019899,GO:0031490,GO:0043565,GO:0045944,GO:0060509,GO:0070062,GO:0070324 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|DNA binding|DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|thyroid hormone receptor activity|nucleus|nucleoplasm|transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|sensory perception of sound|negative regulation of female receptivity|regulation of heart contraction|female courtship behavior|zinc ion binding|animal organ morphogenesis|nuclear body|enzyme binding|chromatin DNA binding|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|Type I pneumocyte differentiation|extracellular exosome|thyroid hormone binding hsa04080,hsa04919 Neuroactive ligand-receptor interaction|Thyroid hormone signaling pathway THSD1 177.40135683118 179.353273458722 175.449440203638 0.978233833262137 -0.031748732199596 0.900768062767518 1 1.68125 1.80772 1.96279 1.5998 GeneID:55901,Genbank:NM_199263.2,HGNC:HGNC:17754,MIM:616821 thrombospondin type 1 domain containing 1 GO:0005576,GO:0005829,GO:0016021 extracellular region|cytosol|integral component of membrane THSD4 582.290871576247 541.750068873509 622.831674278985 1.14966607309174 0.201214883211421 0.396211677998787 1 1.32202 1.49578 1.89662 1.35126 GeneID:79875,Genbank:XM_006720692.3,HGNC:HGNC:25835,MIM:614476 thrombospondin type 1 domain containing 4 GO:0001527,GO:0005578,GO:0008233,GO:0031012,GO:0048251,GO:0070062 microfibril|proteinaceous extracellular matrix|peptidase activity|extracellular matrix|elastic fiber assembly|extracellular exosome THSD7A 6.7147981231973 5.67894306964064 7.75065317675395 1.3648055776767 0.448695447775629 0.74004260520283 1 0.0121264 0.0145049 0.00875925 0.0271252 GeneID:221981,Genbank:NM_015204.2,HGNC:HGNC:22207,MIM:612249 thrombospondin type 1 domain containing 7A GO:0001525,GO:0005886,GO:0016021,GO:0030154,GO:0070062 angiogenesis|plasma membrane|integral component of membrane|cell differentiation|extracellular exosome THSD7B 1.48835427179097 2.00831188251439 0.968396661067546 0.482194359102791 -1.05231332105607 0.812659389660536 1 0.00630161 0.0175518 0 0.0111623 GeneID:80731,Genbank:NM_001316349.1,HGNC:HGNC:29348 thrombospondin type 1 domain containing 7B GO:0016021 integral component of membrane THTPA 342.735232476379 327.823256939878 357.64720801288 1.09097570243002 0.125618971162838 0.532659276996834 1 5.67667 6.74169 7.1048 7.22393 GeneID:79178,Genbank:NM_024328.5,HGNC:HGNC:18987,MIM:611612 thiamine triphosphatase GO:0000287,GO:0005829,GO:0006091,GO:0006772,GO:0016311,GO:0016787,GO:0042357,GO:0042723,GO:0050333 magnesium ion binding|cytosol|generation of precursor metabolites and energy|thiamine metabolic process|dephosphorylation|hydrolase activity|thiamine diphosphate metabolic process|thiamine-containing compound metabolic process|thiamin-triphosphatase activity hsa00730 Thiamine metabolism THUMPD1 225.740268718254 247.432946709509 204.047590727 0.824658128355701 -0.278131937645342 0.216879651750796 1 1.80012 1.50229 1.51986 1.1628 GeneID:55623,Genbank:XM_017023433.2,HGNC:HGNC:23807,MIM:616662 THUMP domain containing 1 GO:0000154,GO:0003723,GO:0005654,GO:0006400 rRNA modification|RNA binding|nucleoplasm|tRNA modification THUMPD2 99.2676461529902 113.23286881491 85.3024234910702 0.753336238707376 -0.408634164062144 0.197186419380116 1 1.41229 1.08619 1.00176 0.932018 GeneID:80745,Genbank:NM_001321470.1,HGNC:HGNC:14890,MIM:611751 THUMP domain containing 2 GO:0003723,GO:0016423,GO:0030488 RNA binding|tRNA (guanine) methyltransferase activity|tRNA methylation THUMPD3 1124.43492243453 1051.30829569614 1197.56154917293 1.13911547552276 0.187914004745388 0.208423338823356 1 7.29634 7.39028 9.04768 8.19346 GeneID:25917,Genbank:XM_017006116.2,HGNC:HGNC:24493 THUMP domain containing 3 GO:0003723,GO:0005730,GO:0005829,GO:0016423,GO:0030488 RNA binding|nucleolus|cytosol|tRNA (guanine) methyltransferase activity|tRNA methylation THY1 8183.13287126649 7760.32565132307 8605.9400912099 1.10896636016076 0.149215602861806 0.263378091669536 1 64.0682 67.2097 74.526 73.1107 GeneID:7070,Genbank:NM_001311162.1,HGNC:HGNC:11801,MIM:188230 Thy-1 cell surface antigen hsa04670 Leukocyte transendothelial migration THYN1 418.179948573334 421.050459169653 415.309437977016 0.986365004318108 -0.0198064802564567 0.903542821849168 1 7.26711 7.90545 7.53167 7.34713 GeneID:29087,Genbank:XM_005271527.4,HGNC:HGNC:29560,MIM:613739 thymocyte nuclear protein 1 GO:0005634 nucleus TIA1 587.642272860139 664.907810240551 510.376735479727 0.767590224718646 -0.38159175599572 0.0790119111779918 0.945231254824065 2.79937 2.69431 2.40531 1.7426 GeneID:7072,Genbank:NM_001351513.1,HGNC:HGNC:11802,MIM:603518 TIA1 cytotoxic granule associated RNA binding protein GO:0003723,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0008143,GO:0008543,GO:0010494,GO:0017091,GO:0017148,GO:0042036,GO:0048024,GO:0097165,GO:1903608,GO:1904037 RNA binding|nucleoplasm|cytoplasm|cytosol|apoptotic process|poly(A) binding|fibroblast growth factor receptor signaling pathway|cytoplasmic stress granule|AU-rich element binding|negative regulation of translation|negative regulation of cytokine biosynthetic process|regulation of mRNA splicing, via spliceosome|nuclear stress granule|protein localization to cytoplasmic stress granule|positive regulation of epithelial cell apoptotic process TIAF1 3.72125447177657 2.59443583384164 4.84807310971151 1.86864251814348 0.901990599778526 0.624604802136433 1 0.221217 0.346067 0.862138 0.836979 GeneID:9220,Genbank:NM_004740.3,HGNC:HGNC:11803,MIM:609517 TGFB1-induced anti-apoptotic factor 1 GO:0005634,GO:0006915,GO:0007249,GO:0043066 nucleus|apoptotic process|I-kappaB kinase/NF-kappaB signaling|negative regulation of apoptotic process TIAL1 1948.13660033575 1960.12351728398 1936.14968338751 0.987769222865256 -0.0177540772860125 0.910552624375185 1 8.6824 8.60146 9.34529 7.94845 GeneID:7073,Genbank:XM_024448151.1,HGNC:HGNC:11804,MIM:603413 TIA1 cytotoxic granule associated RNA binding protein like 1 GO:0003677,GO:0005634,GO:0005737,GO:0006915,GO:0007281,GO:0008284,GO:0010494,GO:0017091,GO:0017145 DNA binding|nucleus|cytoplasm|apoptotic process|germ cell development|positive regulation of cell proliferation|cytoplasmic stress granule|AU-rich element binding|stem cell division TIAM1 372.752130032582 347.57898349648 397.925276568683 1.14484849620579 0.195156691567244 0.297926899291908 1 1.29174 1.17178 1.69421 1.26399 GeneID:7074,Genbank:XM_011529712.1,HGNC:HGNC:11805,MIM:600687 T cell lymphoma invasion and metastasis 1 hsa04014,hsa04015,hsa04024,hsa04062,hsa04530,hsa04810,hsa05205 Ras signaling pathway|Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Tight junction|Regulation of actin cytoskeleton|Proteoglycans in cancer TIAM2 92.3249707446687 100.318524575495 84.3314169138424 0.840636535183277 -0.250445935587209 0.430786440845147 1 0.54054 0.444894 0.493135 0.426523 GeneID:26230,Genbank:NM_012454.3,HGNC:HGNC:11806,MIM:604709 T cell lymphoma invasion and metastasis 2 GO:0005057,GO:0005085,GO:0005089,GO:0005096,GO:0005829,GO:0007186,GO:0016020,GO:0019216,GO:0030027,GO:0030175,GO:0030426,GO:0035023,GO:0035556,GO:0043065,GO:0051056,GO:0070062 signal transducer activity, downstream of receptor|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|GTPase activator activity|cytosol|G-protein coupled receptor signaling pathway|membrane|regulation of lipid metabolic process|lamellipodium|filopodium|growth cone|regulation of Rho protein signal transduction|intracellular signal transduction|positive regulation of apoptotic process|regulation of small GTPase mediated signal transduction|extracellular exosome TICAM1 600.68496286996 627.107719707497 574.262206032423 0.915731361591717 -0.127003662658521 0.431127354902386 1 9.00903 9.68455 8.5121 8.97086 GeneID:148022,Genbank:NM_182919.3,HGNC:HGNC:18348,MIM:607601 toll like receptor adaptor molecule 1 GO:0002281,GO:0002756,GO:0004871,GO:0005776,GO:0005829,GO:0006954,GO:0007249,GO:0010008,GO:0010508,GO:0010628,GO:0019901,GO:0030890,GO:0031398,GO:0031663,GO:0032092,GO:0032755,GO:0032760,GO:0032816,GO:0034128,GO:0034138,GO:0035666,GO:0043123,GO:0043330,GO:0043496,GO:0045080,GO:0045087,GO:0045359,GO:0045429,GO:0051092,GO:0051607,GO:0070266,GO:0071222,GO:0097190,GO:0097342,GO:0140052,GO:1900017 macrophage activation involved in immune response|MyD88-independent toll-like receptor signaling pathway|signal transducer activity|autophagosome|cytosol|inflammatory response|I-kappaB kinase/NF-kappaB signaling|endosome membrane|positive regulation of autophagy|positive regulation of gene expression|protein kinase binding|positive regulation of B cell proliferation|positive regulation of protein ubiquitination|lipopolysaccharide-mediated signaling pathway|positive regulation of protein binding|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|positive regulation of natural killer cell activation|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|response to exogenous dsRNA|regulation of protein homodimerization activity|positive regulation of chemokine biosynthetic process|innate immune response|positive regulation of interferon-beta biosynthetic process|positive regulation of nitric oxide biosynthetic process|positive regulation of NF-kappaB transcription factor activity|defense response to virus|necroptotic process|cellular response to lipopolysaccharide|apoptotic signaling pathway|ripoptosome|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of cytokine production involved in inflammatory response hsa04064,hsa04217,hsa04620,hsa04621,hsa05133,hsa05142,hsa05160,hsa05161,hsa05164,hsa05165,hsa05167,hsa05168 NF-kappa B signaling pathway|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Pertussis|Chagas disease (American trypanosomiasis)|Hepatitis C|Hepatitis B|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection TICAM2 21.3810053039757 25.8002795143615 16.9617310935898 0.657424315273335 -0.605103278451599 0.34139608510089 1 6.88956 5.39261 6.10729 5.19899 GeneID:353376,Genbank:NM_021649.7,HGNC:HGNC:21354,MIM:608321 toll like receptor adaptor molecule 2 GO:0002756,GO:0004871,GO:0005543,GO:0005769,GO:0005770,GO:0005783,GO:0005794,GO:0005886,GO:0006954,GO:0007249,GO:0010008,GO:0030667,GO:0031901,GO:0031902,GO:0032729,GO:0032755,GO:0034128,GO:0034142,GO:0034144,GO:0034145,GO:0035666,GO:0035669,GO:0043123,GO:0043312,GO:0045087,GO:0051607,GO:0070266,GO:0070671,GO:0071222,GO:0071650,GO:0071651,GO:0097190,GO:2000494 MyD88-independent toll-like receptor signaling pathway|signal transducer activity|phospholipid binding|early endosome|late endosome|endoplasmic reticulum|Golgi apparatus|plasma membrane|inflammatory response|I-kappaB kinase/NF-kappaB signaling|endosome membrane|secretory granule membrane|early endosome membrane|late endosome membrane|positive regulation of interferon-gamma production|positive regulation of interleukin-6 production|negative regulation of MyD88-independent toll-like receptor signaling pathway|toll-like receptor 4 signaling pathway|negative regulation of toll-like receptor 4 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway|TRAM-dependent toll-like receptor 4 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|innate immune response|defense response to virus|necroptotic process|response to interleukin-12|cellular response to lipopolysaccharide|negative regulation of chemokine (C-C motif) ligand 5 production|positive regulation of chemokine (C-C motif) ligand 5 production|apoptotic signaling pathway|positive regulation of interleukin-18-mediated signaling pathway hsa04064,hsa04217,hsa04620,hsa05133,hsa05161 NF-kappa B signaling pathway|Necroptosis|Toll-like receptor signaling pathway|Pertussis|Hepatitis B TICRR 793.011315509018 791.633372592805 794.389258425232 1.00348126535318 0.00501368233643738 0.983572982139589 1 3.68489 3.7873 4.32899 3.31444 GeneID:90381,Genbank:NM_152259.3,HGNC:HGNC:28704,MIM:613298 TOPBP1 interacting checkpoint and replication regulator GO:0000075,GO:0001731,GO:0003682,GO:0005634,GO:0005654,GO:0006260,GO:0006281,GO:0010212,GO:0030174,GO:0033314 cell cycle checkpoint|formation of translation preinitiation complex|chromatin binding|nucleus|nucleoplasm|DNA replication|DNA repair|response to ionizing radiation|regulation of DNA-dependent DNA replication initiation|mitotic DNA replication checkpoint TIFA 283.587306823776 309.374048454877 257.800565192676 0.833297319152084 -0.263096756157929 0.207297238764255 1 4.10371 5.29567 3.57245 4.20052 GeneID:92610,Genbank:NM_052864.2,HGNC:HGNC:19075,MIM:609028 TRAF interacting protein with forkhead associated domain GO:0005622,GO:0007249 intracellular|I-kappaB kinase/NF-kappaB signaling TIGAR 182.58609060855 198.474849789313 166.697331427788 0.839891460327302 -0.25172519528786 0.302435129966488 1 1.1815 0.989693 0.841889 0.986485 GeneID:57103,Genbank:NM_020375.2,HGNC:HGNC:1185,MIM:610775 TP53 induced glycolysis regulatory phosphatase GO:0002931,GO:0004083,GO:0004331,GO:0005622,GO:0005634,GO:0005737,GO:0005741,GO:0005829,GO:0006003,GO:0006914,GO:0006915,GO:0006974,GO:0009410,GO:0010332,GO:0010666,GO:0030388,GO:0043069,GO:0043456,GO:0045739,GO:0045820,GO:0060576,GO:0071279,GO:0071456,GO:1901215,GO:1901525,GO:1902153,GO:1903301,GO:1904024,GO:2000378 response to ischemia|bisphosphoglycerate 2-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|intracellular|nucleus|cytoplasm|mitochondrial outer membrane|cytosol|fructose 2,6-bisphosphate metabolic process|autophagy|apoptotic process|cellular response to DNA damage stimulus|response to xenobiotic stimulus|response to gamma radiation|positive regulation of cardiac muscle cell apoptotic process|fructose 1,6-bisphosphate metabolic process|negative regulation of programmed cell death|regulation of pentose-phosphate shunt|positive regulation of DNA repair|negative regulation of glycolytic process|intestinal epithelial cell development|cellular response to cobalt ion|cellular response to hypoxia|negative regulation of neuron death|negative regulation of mitophagy|regulation of response to DNA damage checkpoint signaling|positive regulation of hexokinase activity|negative regulation of glucose catabolic process to lactate via pyruvate|negative regulation of reactive oxygen species metabolic process hsa00051,hsa05230 Fructose and mannose metabolism|Central carbon metabolism in cancer TIGD1 71.2619834851791 66.4369712563908 76.0869957139673 1.14525081855907 0.195663594011298 0.570994284074301 1 1.12077 0.9834 1.24706 1.1618 GeneID:200765,Genbank:NM_145702.2,HGNC:HGNC:14523,MIM:612972 tigger transposable element derived 1 GO:0003677,GO:0005634 DNA binding|nucleus TIGD2 56.3681913979859 62.8143663439495 49.9220164520222 0.794754756876265 -0.33141834848006 0.402732032391466 1 1.02607 0.945442 0.959889 0.684013 GeneID:166815,Genbank:NM_145715.2,HGNC:HGNC:18333,MIM:612973 tigger transposable element derived 2 GO:0003677,GO:0005634 DNA binding|nucleus TIGD3 15.5528848506297 18.507043414794 12.5987262864655 0.680753051910734 -0.554796549801014 0.464167934533354 1 0.466779 0.430304 0.297767 0.377995 GeneID:220359,Genbank:NM_145719.2,HGNC:HGNC:18334 tigger transposable element derived 3 GO:0003677,GO:0005634 DNA binding|nucleus TIGD4 8.21413693225714 9.15746915802711 7.27080470648717 0.793975341987785 -0.332833891731138 0.784886728721725 1 0.0932641 0.105093 0.116426 0.0720923 GeneID:201798,Genbank:XM_005262807.4,HGNC:HGNC:18335 tigger transposable element derived 4 GO:0003677,GO:0005634 DNA binding|nucleus TIGD5 327.453766521223 334.578395362803 320.329137679644 0.957411303656628 -0.0627892555801605 0.73860687623776 1 8.90268 8.99097 8.48985 8.89964 GeneID:84948,Genbank:NM_032862.4,HGNC:HGNC:18336 tigger transposable element derived 5 GO:0003677,GO:0005634 DNA binding|nucleus TIGD6 195.833447424292 191.989268705136 199.677626143448 1.04004576656897 0.0566470146637915 0.825683447682956 1 1.52528 1.64151 1.72586 1.49432 GeneID:81789,Genbank:NM_030953.3,HGNC:HGNC:18332 tigger transposable element derived 6 GO:0003677,GO:0005634 DNA binding|nucleus TIGD7 63.8801898906381 54.5890137151522 73.1713660661239 1.34040461782173 0.422668561885578 0.24010404257665 1 0.591221 0.555264 0.714016 0.802773 GeneID:91151,Genbank:NM_033208.3,HGNC:HGNC:18331,MIM:612969 tigger transposable element derived 7 GO:0003677,GO:0005634 DNA binding|nucleus TIGIT 6.98428194754515 6.21704074628294 7.75152314880735 1.24681877844244 0.31825178879084 0.82432988655874 1 0.0129798 0.00903245 0.00898066 0.0183929 GeneID:201633,Genbank:XM_024453388.1,HGNC:HGNC:26838,MIM:612859 T cell immunoreceptor with Ig and ITIM domains GO:0004872,GO:0005102,GO:0005887,GO:0005913,GO:0007156,GO:0007157,GO:0008037,GO:0009986,GO:0032695,GO:0032733,GO:0042802,GO:0042803,GO:0050839,GO:0050868 receptor activity|receptor binding|integral component of plasma membrane|cell-cell adherens junction|homophilic cell adhesion via plasma membrane adhesion molecules|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cell recognition|cell surface|negative regulation of interleukin-12 production|positive regulation of interleukin-10 production|identical protein binding|protein homodimerization activity|cell adhesion molecule binding|negative regulation of T cell activation hsa04514 Cell adhesion molecules (CAMs) TIMELESS 2707.43995782837 2492.966057028 2921.91385862874 1.17206323383003 0.229050406511072 0.0948967217206326 0.997287332728118 15.1135 14.9105 18.9661 16.82 GeneID:8914,Genbank:NM_001330295.1,HGNC:HGNC:11813,MIM:603887 timeless circadian regulator TIMM10 1244.34427728275 1289.85536458808 1198.83318997742 0.929432262632232 -0.105578370060593 0.618959245255893 1 17.1732 19.4402 16.5024 19.8469 GeneID:26519,Genbank:NM_012456.2,HGNC:HGNC:11814,MIM:602251 translocase of inner mitochondrial membrane 10 GO:0005215,GO:0005739,GO:0005743,GO:0005744,GO:0005758,GO:0006626,GO:0007605,GO:0008270,GO:0008565,GO:0042719,GO:0042721,GO:0042803,GO:0045039,GO:0051087,GO:0072321 transporter activity|mitochondrion|mitochondrial inner membrane|mitochondrial inner membrane presequence translocase complex|mitochondrial intermembrane space|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|protein transporter activity|mitochondrial intermembrane space protein transporter complex|mitochondrial inner membrane protein insertion complex|protein homodimerization activity|protein import into mitochondrial inner membrane|chaperone binding|chaperone-mediated protein transport TIMM10B 604.550921517405 610.607971174363 598.493871860447 0.980160594217895 -0.0289099482102929 0.870033221974807 1 9.52973 9.61489 9.24952 9.59108 GeneID:26515,Genbank:NM_012192.3,HGNC:HGNC:4022,MIM:607388 translocase of inner mitochondrial membrane 10B GO:0005743,GO:0005758,GO:0006626,GO:0007160,GO:0042719,GO:0042721,GO:0046872 mitochondrial inner membrane|mitochondrial intermembrane space|protein targeting to mitochondrion|cell-matrix adhesion|mitochondrial intermembrane space protein transporter complex|mitochondrial inner membrane protein insertion complex|metal ion binding TIMM13 2150.97207836098 2241.92234806287 2060.02180865909 0.918864032217284 -0.122076698616143 0.391006526438549 1 53.8185 56.9915 49.9081 54.0346 GeneID:26517,Genbank:NM_012458.3,HGNC:HGNC:11816,MIM:607383 translocase of inner mitochondrial membrane 13 GO:0001650,GO:0005739,GO:0005743,GO:0006626,GO:0007605,GO:0008270,GO:0008565,GO:0042719,GO:0045039,GO:0072321 fibrillar center|mitochondrion|mitochondrial inner membrane|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|protein transporter activity|mitochondrial intermembrane space protein transporter complex|protein import into mitochondrial inner membrane|chaperone-mediated protein transport TIMM17A 1917.64992897417 1999.54974350378 1835.75011444456 0.918081743356781 -0.123305482114084 0.387389859602776 1 50.9708 52.296 48.767 47.7049 GeneID:10440,Genbank:NM_006335.2,HGNC:HGNC:17315,MIM:605057 translocase of inner mitochondrial membrane 17A GO:0005654,GO:0005739,GO:0005743,GO:0005744,GO:0006626,GO:0010954,GO:0015450,GO:0030150,GO:0031305 nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial inner membrane presequence translocase complex|protein targeting to mitochondrion|positive regulation of protein processing|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM17B 743.01139839617 731.990774379771 754.032022412569 1.0301113740832 0.0428003278463793 0.82177845281006 1 24.1272 25.0546 23.4613 26.3698 GeneID:10245,Genbank:NM_005834.4,HGNC:HGNC:17310,MIM:300249 translocase of inner mitochondrial membrane 17B GO:0005743,GO:0005744,GO:0006626,GO:0015450,GO:0030150,GO:0031305 mitochondrial inner membrane|mitochondrial inner membrane presequence translocase complex|protein targeting to mitochondrion|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM21 309.02806356806 326.813688170639 291.242438965482 0.891157407132272 -0.166247814170247 0.412226568728458 1 6.89196 7.32838 6.11142 7.14523 GeneID:29090,Genbank:NM_014177.2,HGNC:HGNC:25010,MIM:615180 translocase of inner mitochondrial membrane 21 GO:0005744,GO:0016021,GO:0030150,GO:0032981,GO:0033617 mitochondrial inner membrane presequence translocase complex|integral component of membrane|protein import into mitochondrial matrix|mitochondrial respiratory chain complex I assembly|mitochondrial respiratory chain complex IV assembly TIMM22 1005.07985860655 1002.18853664338 1007.97118056972 1.00577001603481 0.00830044961834782 0.988831874586797 1 23.9179 27.3401 25.2785 27.4671 GeneID:29928,Genbank:NM_013337.3,HGNC:HGNC:17317,MIM:607251 translocase of inner mitochondrial membrane 22 GO:0005743,GO:0006626,GO:0015266,GO:0016021,GO:0030943,GO:0042721,GO:0045039 mitochondrial inner membrane|protein targeting to mitochondrion|protein channel activity|integral component of membrane|mitochondrion targeting sequence binding|mitochondrial inner membrane protein insertion complex|protein import into mitochondrial inner membrane TIMM23 2514.93810886611 2491.05583169656 2538.82038603566 1.01917442143662 0.0274009753583299 0.858678572414963 1 79.0568 87.0365 82.2036 89.0195 GeneID:100287932,Genbank:NM_006327.3,HGNC:HGNC:17312,MIM:605034 translocase of inner mitochondrial membrane 23 GO:0005739,GO:0005743,GO:0005744,GO:0005758,GO:0006626,GO:0015266,GO:0015450,GO:0030150,GO:0031305 mitochondrion|mitochondrial inner membrane|mitochondrial inner membrane presequence translocase complex|mitochondrial intermembrane space|protein targeting to mitochondrion|protein channel activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM23B 267.418908915005 281.833997395894 253.003820434115 0.897705112838882 -0.155686483008287 0.451154059482343 1 2.22793 2.42369 2.61513 2.16099 GeneID:100652748,Genbank:NM_001290117.1,HGNC:HGNC:23581 translocase of inner mitochondrial membrane 23 homolog B GO:0005744,GO:0015266,GO:0015450,GO:0030150,GO:0031305 mitochondrial inner membrane presequence translocase complex|protein channel activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein import into mitochondrial matrix|integral component of mitochondrial inner membrane TIMM29 578.135001047596 586.84542950784 569.424572587352 0.970314403002002 -0.0434758072187823 0.784026932621354 1 25.4509 26.3769 24.9471 25.2073 GeneID:90580,Genbank:NM_138358.3,HGNC:HGNC:25152,MIM:617380 translocase of inner mitochondrial membrane 29 GO:0005743,GO:0005758,GO:0016021,GO:0042721,GO:0045039 mitochondrial inner membrane|mitochondrial intermembrane space|integral component of membrane|mitochondrial inner membrane protein insertion complex|protein import into mitochondrial inner membrane TIMM44 1461.94389280487 1462.39464769323 1461.4931379165 0.999383538651384 -0.000889639973059952 0.991664043704375 1 25.0223 25.2187 22.9311 27.5974 GeneID:10469,Genbank:NM_006351.3,HGNC:HGNC:17316,MIM:605058 translocase of inner mitochondrial membrane 44 GO:0005524,GO:0005739,GO:0005743,GO:0005759,GO:0006626,GO:0030150,GO:0051087 ATP binding|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|protein targeting to mitochondrion|protein import into mitochondrial matrix|chaperone binding TIMM50 2513.04534901131 2617.11985185919 2408.97084616343 0.920466383857852 -0.11956306068551 0.447570238781635 1 17.1071 20.3289 16.8978 17.9348 GeneID:92609,Genbank:NM_001001563.3,HGNC:HGNC:23656,MIM:607381 translocase of inner mitochondrial membrane 50 GO:0001836,GO:0003723,GO:0004721,GO:0004722,GO:0004725,GO:0005134,GO:0005654,GO:0005739,GO:0005743,GO:0005744,GO:0006470,GO:0007006,GO:0016021,GO:0016607,GO:0030150,GO:0043021 release of cytochrome c from mitochondria|RNA binding|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|interleukin-2 receptor binding|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial inner membrane presequence translocase complex|protein dephosphorylation|mitochondrial membrane organization|integral component of membrane|nuclear speck|protein import into mitochondrial matrix|ribonucleoprotein complex binding TIMM8A 374.000267133992 370.967123620632 377.033410647353 1.01635262706709 0.0234010370090716 0.889222535103559 1 7.71652 6.62187 6.49787 7.29444 GeneID:1678,Genbank:NM_004085.3,HGNC:HGNC:11817,MIM:300356 translocase of inner mitochondrial membrane 8A GO:0005739,GO:0005743,GO:0005758,GO:0007399,GO:0046872,GO:0072321 mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|nervous system development|metal ion binding|chaperone-mediated protein transport TIMM8B 1174.51275791956 1193.30250674823 1155.7230090909 0.968507987333631 -0.0461641480318819 0.791353459414445 1 56.3549 61.5572 50.1868 62.7756 GeneID:26521,Genbank:NM_012459.2,HGNC:HGNC:11818,MIM:606659 translocase of inner mitochondrial membrane 8 homolog B GO:0005615,GO:0005743,GO:0006626,GO:0007605,GO:0008270,GO:0016020,GO:0042719,GO:0046873,GO:0072321,GO:0098655 extracellular space|mitochondrial inner membrane|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|membrane|mitochondrial intermembrane space protein transporter complex|metal ion transmembrane transporter activity|chaperone-mediated protein transport|cation transmembrane transport TIMM9 357.208803486907 380.019748575036 334.397858398779 0.879948633334646 -0.184508785451403 0.322317290482016 1 8.67604 10.3884 9.04461 8.33043 GeneID:26520,Genbank:NM_001304485.1,HGNC:HGNC:11819,MIM:607384 translocase of inner mitochondrial membrane 9 GO:0005215,GO:0005739,GO:0005743,GO:0005758,GO:0006626,GO:0007605,GO:0008270,GO:0008565,GO:0042719,GO:0042721,GO:0042803,GO:0045039,GO:0051087,GO:0072321 transporter activity|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|protein targeting to mitochondrion|sensory perception of sound|zinc ion binding|protein transporter activity|mitochondrial intermembrane space protein transporter complex|mitochondrial inner membrane protein insertion complex|protein homodimerization activity|protein import into mitochondrial inner membrane|chaperone binding|chaperone-mediated protein transport TIMMDC1 1057.61797652659 1107.78115977997 1007.45479327321 0.909434850357373 -0.136957804380469 0.365979338676927 1 31.4199 32.0666 26.6818 30.8432 GeneID:51300,Genbank:NM_016589.3,HGNC:HGNC:1321,MIM:615534 translocase of inner mitochondrial membrane domain containing 1 GO:0005634,GO:0005654,GO:0005739,GO:0005743,GO:0016021,GO:0032981 nucleus|nucleoplasm|mitochondrion|mitochondrial inner membrane|integral component of membrane|mitochondrial respiratory chain complex I assembly TIMP1 2121.23930506566 2108.31616877299 2134.16244135833 1.01225920142726 0.01757875715924 0.909160476202448 1 64.7841 65.3488 63.6664 70.749 GeneID:7076,Genbank:NM_003254.2,HGNC:HGNC:11820,MIM:305370 TIMP metallopeptidase inhibitor 1 GO:0001775,GO:0002020,GO:0002576,GO:0005125,GO:0005576,GO:0005578,GO:0005604,GO:0005615,GO:0005788,GO:0007568,GO:0008083,GO:0008191,GO:0008270,GO:0008284,GO:0009725,GO:0010951,GO:0019221,GO:0022617,GO:0031093,GO:0034097,GO:0042060,GO:0043066,GO:0043086,GO:0043434,GO:0043687,GO:0044267,GO:0051045,GO:0051216,GO:0070062,GO:1901164,GO:1905049,GO:2001044 cell activation|protease binding|platelet degranulation|cytokine activity|extracellular region|proteinaceous extracellular matrix|basement membrane|extracellular space|endoplasmic reticulum lumen|aging|growth factor activity|metalloendopeptidase inhibitor activity|zinc ion binding|positive regulation of cell proliferation|response to hormone|negative regulation of endopeptidase activity|cytokine-mediated signaling pathway|extracellular matrix disassembly|platelet alpha granule lumen|response to cytokine|wound healing|negative regulation of apoptotic process|negative regulation of catalytic activity|response to peptide hormone|post-translational protein modification|cellular protein metabolic process|negative regulation of membrane protein ectodomain proteolysis|cartilage development|extracellular exosome|negative regulation of trophoblast cell migration|negative regulation of metallopeptidase activity|regulation of integrin-mediated signaling pathway hsa04066 HIF-1 signaling pathway TIMP2 16955.8724343232 16009.4127741759 17902.3320944704 1.11823789835364 0.161227145483441 0.217384369218201 1 200.039 209.43 238.859 223.198 GeneID:7077,Genbank:NM_003255.4,HGNC:HGNC:11821,MIM:188825 TIMP metallopeptidase inhibitor 2 TIMP3 509.046657498346 491.782403184074 526.310911812619 1.07021094777891 0.0978951922518377 0.57829621687157 1 3.65181 3.79277 4.14899 3.92612 GeneID:7078,Genbank:NM_000362.4,HGNC:HGNC:11822,MIM:188826 TIMP metallopeptidase inhibitor 3 hsa05205,hsa05206 Proteoglycans in cancer|MicroRNAs in cancer TIMP4 133.467945791774 122.025745085674 144.910146497875 1.18753748560301 0.247973054024649 0.367425211973676 1 3.06732 3.76887 4.53084 4.11279 GeneID:7079,Genbank:NM_003256.3,HGNC:HGNC:11823,MIM:601915 TIMP metallopeptidase inhibitor 4 GO:0002020,GO:0005578,GO:0005615,GO:0007219,GO:0007417,GO:0008191,GO:0009725,GO:0030017,GO:0032496,GO:0034097,GO:0042493,GO:0042698,GO:0043086,GO:0043434,GO:0046872,GO:0051045 protease binding|proteinaceous extracellular matrix|extracellular space|Notch signaling pathway|central nervous system development|metalloendopeptidase inhibitor activity|response to hormone|sarcomere|response to lipopolysaccharide|response to cytokine|response to drug|ovulation cycle|negative regulation of catalytic activity|response to peptide hormone|metal ion binding|negative regulation of membrane protein ectodomain proteolysis TINAGL1 1257.8922604023 1566.5779425563 949.206578248296 0.605910853499831 -0.722822546526436 0.0114658563389305 0.433106497934695 24.0001 27.0516 12.9354 18.7285 GeneID:64129,Genbank:XM_011541946.1,HGNC:HGNC:19168,MIM:616064 tubulointerstitial nephritis antigen like 1 GO:0005044,GO:0005201,GO:0005576,GO:0005615,GO:0005737,GO:0006955,GO:0007155,GO:0008234,GO:0016197,GO:0030247,GO:0031012,GO:0043236,GO:0070062 scavenger receptor activity|extracellular matrix structural constituent|extracellular region|extracellular space|cytoplasm|immune response|cell adhesion|cysteine-type peptidase activity|endosomal transport|polysaccharide binding|extracellular matrix|laminin binding|extracellular exosome TINF2 1150.47382392469 1140.28956844342 1160.65807940595 1.01786257765239 0.0255427952816651 0.884838255154678 1 15.3031 16.5009 16.7051 16.2745 GeneID:26277,Genbank:XM_011536642.2,HGNC:HGNC:11824,MIM:604319 TERF1 interacting nuclear factor 2 GO:0000781,GO:0000783,GO:0000784,GO:0005654,GO:0010370,GO:0010836,GO:0016233,GO:0016363,GO:0016604,GO:0032202,GO:0032211,GO:0042162,GO:0050680,GO:0070187,GO:0070198,GO:1904356 chromosome, telomeric region|nuclear telomere cap complex|nuclear chromosome, telomeric region|nucleoplasm|perinucleolar chromocenter|negative regulation of protein ADP-ribosylation|telomere capping|nuclear matrix|nuclear body|telomere assembly|negative regulation of telomere maintenance via telomerase|telomeric DNA binding|negative regulation of epithelial cell proliferation|shelterin complex|protein localization to chromosome, telomeric region|regulation of telomere maintenance via telomere lengthening TIPARP 262.383367912813 258.694780299421 266.071955526206 1.02851690791073 0.0405655106916891 0.829272838221543 1 2.33099 1.97862 2.3917 2.13674 GeneID:25976,Genbank:NM_015508.4,HGNC:HGNC:23696,MIM:612480 TCDD inducible poly(ADP-ribose) polymerase GO:0001570,GO:0001822,GO:0003950,GO:0005634,GO:0006471,GO:0008209,GO:0008210,GO:0008585,GO:0009791,GO:0010629,GO:0030097,GO:0035326,GO:0044236,GO:0045732,GO:0046872,GO:0048008,GO:0048705,GO:0048745,GO:0060021,GO:0060325,GO:0071407 vasculogenesis|kidney development|NAD+ ADP-ribosyltransferase activity|nucleus|protein ADP-ribosylation|androgen metabolic process|estrogen metabolic process|female gonad development|post-embryonic development|negative regulation of gene expression|hemopoiesis|enhancer binding|multicellular organism metabolic process|positive regulation of protein catabolic process|metal ion binding|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|smooth muscle tissue development|palate development|face morphogenesis|cellular response to organic cyclic compound TIPIN 482.6975305106 505.974856530622 459.420204490579 0.907990186786634 -0.139251389387431 0.432838727151712 1 4.2513 4.24083 3.74437 3.75274 GeneID:54962,Genbank:XM_017022391.2,HGNC:HGNC:30750,MIM:610716 TIMELESS interacting protein TIPRL 1280.34811683574 1302.13352459977 1258.5627090717 0.966538903495735 -0.0491002923517175 0.748900508968125 1 13.2465 13.7309 13.5767 13.3561 GeneID:261726,Genbank:NM_152902.4,HGNC:HGNC:30231,MIM:611807 TOR signaling pathway regulator GO:0000077,GO:0005737,GO:0032515 DNA damage checkpoint|cytoplasm|negative regulation of phosphoprotein phosphatase activity TIRAP 162.540356018156 148.200426142407 176.880285893905 1.19352076440009 0.255223666073187 0.293179257136617 1 2.00419 1.7782 2.35049 2.61593 GeneID:114609,Genbank:NM_001039661.1,HGNC:HGNC:17192,MIM:606252 TIR domain containing adaptor protein hsa04064,hsa04620,hsa05133,hsa05152,hsa05161 NF-kappa B signaling pathway|Toll-like receptor signaling pathway|Pertussis|Tuberculosis|Hepatitis B TJAP1 868.542570933169 862.808378735353 874.276763130984 1.01329192515775 0.0190498684179277 0.924634156495933 1 7.4428 7.77241 7.86761 7.64177 GeneID:93643,Genbank:NM_001350561.1,HGNC:HGNC:17949,MIM:612658 tight junction associated protein 1 GO:0005768,GO:0005794,GO:0005802,GO:0005886,GO:0005923,GO:0007030 endosome|Golgi apparatus|trans-Golgi network|plasma membrane|bicellular tight junction|Golgi organization hsa04530 Tight junction TJP1 1557.85088073995 1625.2285553086 1490.47320617131 0.917085293205602 -0.12487217746577 0.603866872332179 1 6.07939 5.84663 6.69195 4.28615 GeneID:7082,Genbank:NM_001355012.1,HGNC:HGNC:11827,MIM:601009 tight junction protein 1 hsa04520,hsa04530,hsa04540,hsa05110,hsa05120,hsa05132 Adherens junction|Tight junction|Gap junction|Vibrio cholerae infection|Epithelial cell signaling in Helicobacter pylori infection|Salmonella infection TJP2 656.880980249037 699.260834652251 614.501125845823 0.878786706467581 -0.186415048815697 0.263707193130493 1 4.01345 3.71288 3.38886 3.35686 GeneID:9414,Genbank:XM_011519206.2,HGNC:HGNC:11828,MIM:607709 tight junction protein 2 hsa04530,hsa05110 Tight junction|Vibrio cholerae infection TJP3 11.562581540532 15.3745099043101 7.75065317675395 0.504123593206776 -0.988150620195094 0.252989639265898 1 0.144705 0.168093 0.0362764 0.136034 GeneID:27134,Genbank:NM_001267560.1,HGNC:HGNC:11829,MIM:612689 tight junction protein 3 GO:0005634,GO:0005886,GO:0005923 nucleus|plasma membrane|bicellular tight junction hsa04530 Tight junction TK1 4907.84409447477 4753.53480367888 5062.15338527066 1.06492401851206 0.0907504989709854 0.583762650799385 1 111.809 125.295 125.806 134.036 GeneID:7083,Genbank:NM_001346663.1,HGNC:HGNC:11830,MIM:188300 thymidine kinase 1 GO:0004797,GO:0005524,GO:0005829,GO:0006139,GO:0006259,GO:0008270,GO:0019206,GO:0042802,GO:0043097,GO:0046104,GO:0051289,GO:0071897 thymidine kinase activity|ATP binding|cytosol|nucleobase-containing compound metabolic process|DNA metabolic process|zinc ion binding|nucleoside kinase activity|identical protein binding|pyrimidine nucleoside salvage|thymidine metabolic process|protein homotetramerization|DNA biosynthetic process hsa00240,hsa00983 Pyrimidine metabolism|Drug metabolism - other enzymes TK2 843.671035246121 830.991955227702 856.35011526454 1.03051553011712 0.0433662468025755 0.785778004226875 1 6.3656 6.49342 7.14467 6.5647 GeneID:7084,Genbank:NM_001172644.1,HGNC:HGNC:11831,MIM:188250 thymidine kinase 2, mitochondrial GO:0004137,GO:0004797,GO:0005524,GO:0005759,GO:0006139,GO:0019206,GO:0043097,GO:0046092,GO:0046104,GO:0071897 deoxycytidine kinase activity|thymidine kinase activity|ATP binding|mitochondrial matrix|nucleobase-containing compound metabolic process|nucleoside kinase activity|pyrimidine nucleoside salvage|deoxycytidine metabolic process|thymidine metabolic process|DNA biosynthetic process hsa00240,hsa00983 Pyrimidine metabolism|Drug metabolism - other enzymes TKFC 373.747489001615 350.577246838017 396.917731165213 1.13218337683109 0.17910764670237 0.345606301610876 1 1.52626 1.48422 1.79655 1.60874 GeneID:26007,Genbank:NM_001351978.1,HGNC:HGNC:24552,MIM:615844 triokinase and FMN cyclase GO:0004371,GO:0005524,GO:0005634,GO:0005829,GO:0006071,GO:0034012,GO:0039534,GO:0044262,GO:0045087,GO:0045088,GO:0046835,GO:0046872,GO:0050354,GO:0061624,GO:0070062 glycerone kinase activity|ATP binding|nucleus|cytosol|glycerol metabolic process|FAD-AMP lyase (cyclizing) activity|negative regulation of MDA-5 signaling pathway|cellular carbohydrate metabolic process|innate immune response|regulation of innate immune response|carbohydrate phosphorylation|metal ion binding|triokinase activity|fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate|extracellular exosome hsa00051,hsa00561,hsa04622 Fructose and mannose metabolism|Glycerolipid metabolism|RIG-I-like receptor signaling pathway TKT 59389.5625707526 53279.9968579096 65499.1282835957 1.22933806580869 0.297881708873851 0.0693765835773139 0.918407228165493 521.273 553.567 643.902 703.845 GeneID:7086,Genbank:NM_001135055.2,HGNC:HGNC:11834,MIM:606781 transketolase hsa00030 Pentose phosphate pathway TKTL1 43.6558663073064 50.9664088027109 36.3453238119019 0.713123107272346 -0.487776942593736 0.268613336784226 1 0.813398 0.689268 0.507876 0.514349 GeneID:8277,Genbank:NM_012253.3,HGNC:HGNC:11835,MIM:300044 transketolase like 1 GO:0004802,GO:0005634,GO:0005737,GO:0006007,GO:0006772,GO:0046872 transketolase activity|nucleus|cytoplasm|glucose catabolic process|thiamine metabolic process|metal ion binding hsa00030 Pentose phosphate pathway TKTL2 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0137607 GeneID:84076,Genbank:NM_032136.4,HGNC:HGNC:25313 transketolase like 2 GO:0004802,GO:0005737,GO:0008152,GO:0046872 transketolase activity|cytoplasm|metabolic process|metal ion binding hsa00030 Pentose phosphate pathway TLCD1 271.662842945596 262.740830029773 280.584855861418 1.06791493286226 0.0947967305220575 0.659828688285286 1 5.68971 5.42486 5.81086 6.25034 GeneID:116238,Genbank:XM_006721671.4,HGNC:HGNC:25177 TLC domain containing 1 GO:0005886,GO:0016021 plasma membrane|integral component of membrane TLCD2 49.4954294100049 35.9859177509883 63.0049410690215 1.75082212728314 0.808032522308657 0.0472682782748106 0.797733134720091 0.211632 0.192406 0.381797 0.311967 GeneID:727910,Genbank:NM_001164407.1,HGNC:HGNC:33522 TLC domain containing 2 GO:0016021 integral component of membrane TLDC1 602.387217168737 609.138773969345 595.635660368128 0.977832451030449 -0.0323408104619075 0.825011434884659 1 3.25833 3.88825 3.89371 3.22194 GeneID:57707,Genbank:XM_005256074.3,HGNC:HGNC:29325 TBC/LysM-associated domain containing 1 GO:0005737,GO:0005765,GO:0016020,GO:1903204 cytoplasm|lysosomal membrane|membrane|negative regulation of oxidative stress-induced neuron death TLDC2 24.2582657554692 23.7919676318472 24.7245638790913 1.03919794536017 0.0554704834911774 0.951303389519025 1 0.203338 0.062019 0.11202 0.0448379 GeneID:140711,Genbank:XM_017027673.1,HGNC:HGNC:16112 TBC/LysM-associated domain containing 2 TLE1 1166.0115769557 1151.92580357571 1180.09735033568 1.0244560428046 0.034858082750009 0.829805076182825 1 8.53407 8.61723 8.93823 8.30087 GeneID:7088,Genbank:NM_001303104.1,HGNC:HGNC:11837,MIM:600189 transducin like enhancer of split 1 GO:0001106,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0007165,GO:0007275,GO:0008134,GO:0009887,GO:0010628,GO:0016055,GO:0030178,GO:0042802,GO:0043124,GO:0045892,GO:1904837,GO:2000811 RNA polymerase II transcription corepressor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|signal transduction|multicellular organism development|transcription factor binding|animal organ morphogenesis|positive regulation of gene expression|Wnt signaling pathway|negative regulation of Wnt signaling pathway|identical protein binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of transcription, DNA-templated|beta-catenin-TCF complex assembly|negative regulation of anoikis TLE2 134.333682558986 132.009469568453 136.657895549519 1.0352128222033 0.0499273918543373 0.875227997436019 1 1.84654 1.85152 1.76906 1.90515 GeneID:7089,Genbank:NM_001144761.1,HGNC:HGNC:11838,MIM:601041 transducin like enhancer of split 2 GO:0003714,GO:0005615,GO:0005634,GO:0005654,GO:0005925,GO:0006351,GO:0007165,GO:0009887,GO:0016055,GO:0016604,GO:0045892,GO:0090090,GO:1904837 transcription corepressor activity|extracellular space|nucleus|nucleoplasm|focal adhesion|transcription, DNA-templated|signal transduction|animal organ morphogenesis|Wnt signaling pathway|nuclear body|negative regulation of transcription, DNA-templated|negative regulation of canonical Wnt signaling pathway|beta-catenin-TCF complex assembly TLE3 895.166766359181 909.28669268044 881.046840037922 0.968942850621436 -0.0455165185725678 0.771197311571682 1 5.18121 4.92815 5.09353 4.68121 GeneID:7090,Genbank:XM_011521983.3,HGNC:HGNC:11839,MIM:600190 transducin like enhancer of split 3 GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0007165,GO:0009887,GO:0016055,GO:1904837 nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|signal transduction|animal organ morphogenesis|Wnt signaling pathway|beta-catenin-TCF complex assembly TLE4 418.060964136323 384.862627664817 451.25930060783 1.17252044799954 0.22961308263003 0.394063917645123 1 1.78534 2.1207 2.83942 1.98921 GeneID:7091,Genbank:NM_001282760.1,HGNC:HGNC:11840,MIM:605132 transducin like enhancer of split 4 GO:0000122,GO:0003682,GO:0003705,GO:0003714,GO:0005634,GO:0005654,GO:0006351,GO:0016055,GO:0070491,GO:1904837,GO:1990830 negative regulation of transcription from RNA polymerase II promoter|chromatin binding|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|transcription corepressor activity|nucleus|nucleoplasm|transcription, DNA-templated|Wnt signaling pathway|repressing transcription factor binding|beta-catenin-TCF complex assembly|cellular response to leukemia inhibitory factor TLE6 29.0008715115323 31.8350238170127 26.1667192060519 0.821947530382194 -0.282881793527196 0.61166620314824 1 0.144019 0.255197 0.228904 0.175996 GeneID:79816,Genbank:XM_011528300.2,HGNC:HGNC:30788,MIM:612399 transducin like enhancer of split 6 GO:0005634,GO:0005737,GO:0006355,GO:0043234,GO:0060136 nucleus|cytoplasm|regulation of transcription, DNA-templated|protein complex|embryonic process involved in female pregnancy TLK1 374.063751141576 383.611910521299 364.515591761853 0.950219692778842 -0.0736669887700757 0.878969154637653 1 2.25797 1.78797 2.45187 1.5157 GeneID:9874,Genbank:NM_001136554.1,HGNC:HGNC:11841,MIM:608438 tousled like kinase 1 GO:0001672,GO:0004674,GO:0005524,GO:0005634,GO:0006468,GO:0006886,GO:0006974,GO:0007049,GO:0016569,GO:0035556 regulation of chromatin assembly or disassembly|protein serine/threonine kinase activity|ATP binding|nucleus|protein phosphorylation|intracellular protein transport|cellular response to DNA damage stimulus|cell cycle|covalent chromatin modification|intracellular signal transduction TLK2 802.56214587458 682.310249337591 922.81404241157 1.35248450878097 0.435612069665495 0.0059816806518286 0.309040636515119 3.05578 2.66483 4.2835 3.41332 GeneID:11011,Genbank:XM_024450552.1,HGNC:HGNC:11842,MIM:608439 tousled like kinase 2 GO:0001672,GO:0004674,GO:0005524,GO:0005634,GO:0005882,GO:0006468,GO:0006974,GO:0007049,GO:0007059,GO:0010507,GO:0016569,GO:0018105,GO:0032435,GO:0035556,GO:0048471,GO:0071480 regulation of chromatin assembly or disassembly|protein serine/threonine kinase activity|ATP binding|nucleus|intermediate filament|protein phosphorylation|cellular response to DNA damage stimulus|cell cycle|chromosome segregation|negative regulation of autophagy|covalent chromatin modification|peptidyl-serine phosphorylation|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|intracellular signal transduction|perinuclear region of cytoplasm|cellular response to gamma radiation TLL1 0.972638154859436 0.490071401957362 1.45520490776151 2.96937324224464 1.5701584476161 0.837389832160054 1 0 0.00424554 0.012707 0 GeneID:7092,Genbank:XM_024454194.1,HGNC:HGNC:11843,MIM:606742 tolloid like 1 GO:0001501,GO:0004222,GO:0004252,GO:0005509,GO:0005576,GO:0008270,GO:0022617,GO:0030154 skeletal system development|metalloendopeptidase activity|serine-type endopeptidase activity|calcium ion binding|extracellular region|zinc ion binding|extracellular matrix disassembly|cell differentiation TLL2 25.8952540584637 22.2257008766052 29.5648072403223 1.33020809577448 0.41165195644659 0.463423188584731 1 0.135841 0.10662 0.165535 0.131252 GeneID:7093,Genbank:NM_012465.3,HGNC:HGNC:11844,MIM:606743 tolloid like 2 GO:0004222,GO:0004252,GO:0005509,GO:0005576,GO:0007275,GO:0008270,GO:0022617,GO:0030154,GO:0048632 metalloendopeptidase activity|serine-type endopeptidase activity|calcium ion binding|extracellular region|multicellular organism development|zinc ion binding|extracellular matrix disassembly|cell differentiation|negative regulation of skeletal muscle tissue growth TLN1 19199.9856184107 18964.3345224535 19435.636714368 1.02485202902092 0.035415624454458 0.793329902900054 1 72.0421 72.7832 76.0481 75.1347 GeneID:7094,Genbank:NM_006289.3,HGNC:HGNC:11845,MIM:186745 talin 1 GO:0001726,GO:0001786,GO:0002576,GO:0005178,GO:0005200,GO:0005576,GO:0005829,GO:0005856,GO:0005925,GO:0006928,GO:0006936,GO:0007016,GO:0007043,GO:0007044,GO:0007229,GO:0009986,GO:0016032,GO:0017166,GO:0030274,GO:0030866,GO:0032587,GO:0033622,GO:0035091,GO:0036498,GO:0045296,GO:0051015,GO:0070062,GO:0070527 ruffle|phosphatidylserine binding|platelet degranulation|integrin binding|structural constituent of cytoskeleton|extracellular region|cytosol|cytoskeleton|focal adhesion|movement of cell or subcellular component|muscle contraction|cytoskeletal anchoring at plasma membrane|cell-cell junction assembly|cell-substrate junction assembly|integrin-mediated signaling pathway|cell surface|viral process|vinculin binding|LIM domain binding|cortical actin cytoskeleton organization|ruffle membrane|integrin activation|phosphatidylinositol binding|IRE1-mediated unfolded protein response|cadherin binding|actin filament binding|extracellular exosome|platelet aggregation hsa04015,hsa04510,hsa04611,hsa05166 Rap1 signaling pathway|Focal adhesion|Platelet activation|Human T-cell leukemia virus 1 infection TLN2 1358.30896768469 1264.5147135095 1452.10322185988 1.14834822113675 0.199560186203411 0.242964280635636 1 2.82352 2.86395 3.80575 2.82353 GeneID:83660,Genbank:XM_024450087.1,HGNC:HGNC:15447,MIM:607349 talin 2 GO:0001726,GO:0003779,GO:0005198,GO:0005200,GO:0005737,GO:0005886,GO:0005925,GO:0007016,GO:0007043,GO:0007155,GO:0015629,GO:0045202,GO:0051015 ruffle|actin binding|structural molecule activity|structural constituent of cytoskeleton|cytoplasm|plasma membrane|focal adhesion|cytoskeletal anchoring at plasma membrane|cell-cell junction assembly|cell adhesion|actin cytoskeleton|synapse|actin filament binding hsa04015,hsa04510,hsa04611,hsa05166 Rap1 signaling pathway|Focal adhesion|Platelet activation|Human T-cell leukemia virus 1 infection TLNRD1 746.487729046033 778.133921402917 714.841536689149 0.9186613216917 -0.122395006573702 0.421633844532387 1 16.6879 19.0656 17.4208 16.1368 GeneID:59274,Genbank:NM_022566.2,HGNC:HGNC:13519,MIM:615466 talin rod domain containing 1 GO:0001725,GO:0003779 stress fiber|actin binding TLR1 40.1392961219954 40.5308305375515 39.7477617064392 0.980679674688957 -0.0281461176721379 1 1 0.224338 0.136548 0.217319 0.134968 GeneID:7096,Genbank:XM_024454199.1,HGNC:HGNC:11847,MIM:601194 toll like receptor 1 GO:0001775,GO:0002224,GO:0002755,GO:0004872,GO:0004888,GO:0005794,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007165,GO:0016020,GO:0030670,GO:0034130,GO:0034137,GO:0035354,GO:0035663,GO:0038123,GO:0042116,GO:0042495,GO:0042535,GO:0042742,GO:0045087,GO:0045121,GO:0045410,GO:0046982,GO:0071723,GO:0071727,GO:2000484 cell activation|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|receptor activity|transmembrane signaling receptor activity|Golgi apparatus|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|signal transduction|membrane|phagocytic vesicle membrane|toll-like receptor 1 signaling pathway|positive regulation of toll-like receptor 2 signaling pathway|Toll-like receptor 1-Toll-like receptor 2 protein complex|Toll-like receptor 2 binding|toll-like receptor TLR1:TLR2 signaling pathway|macrophage activation|detection of triacyl bacterial lipopeptide|positive regulation of tumor necrosis factor biosynthetic process|defense response to bacterium|innate immune response|membrane raft|positive regulation of interleukin-6 biosynthetic process|protein heterodimerization activity|lipopeptide binding|cellular response to triacyl bacterial lipopeptide|positive regulation of interleukin-8 secretion hsa04620,hsa05152 Toll-like receptor signaling pathway|Tuberculosis TLR10 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0168082 GeneID:81793,Genbank:XM_011513760.2,HGNC:HGNC:15634,MIM:606270 toll like receptor 10 GO:0002224,GO:0002755,GO:0004888,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0016020,GO:0034166,GO:0045087,GO:0050707,GO:0050729 toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|transmembrane signaling receptor activity|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|membrane|toll-like receptor 10 signaling pathway|innate immune response|regulation of cytokine secretion|positive regulation of inflammatory response TLR3 28.7665555729123 23.10979113115 34.4233200146745 1.4895556528105 0.574882026597719 0.503925996045978 1 0.272567 0.302179 0.6424 0.208188 GeneID:7098,Genbank:NM_003265.2,HGNC:HGNC:11849,MIM:603029 toll like receptor 3 hsa04217,hsa04620,hsa05160,hsa05161,hsa05164,hsa05165,hsa05167,hsa05168 Necroptosis|Toll-like receptor signaling pathway|Hepatitis C|Hepatitis B|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection TLR4 532.99037128089 593.435854795639 472.544887766142 0.796286378632904 -0.328640715965007 0.0596217373602517 0.879410748501007 4.10263 3.76991 3.49912 2.84421 GeneID:7099,Genbank:NM_003266.3,HGNC:HGNC:11850,MIM:603030 toll like receptor 4 hsa04064,hsa04066,hsa04145,hsa04151,hsa04217,hsa04620,hsa04621,hsa05130,hsa05132,hsa05133,hsa05134,hsa05140,hsa05142,hsa05144,hsa05145,hsa05146,hsa05152,hsa05161,hsa05162,hsa05164,hsa05170,hsa05205,hsa05321,hsa05323 NF-kappa B signaling pathway|HIF-1 signaling pathway|Phagosome|PI3K-Akt signaling pathway|Necroptosis|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|Pathogenic Escherichia coli infection|Salmonella infection|Pertussis|Legionellosis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis B|Measles|Influenza A|Human immunodeficiency virus 1 infection|Proteoglycans in cancer|Inflammatory bowel disease (IBD)|Rheumatoid arthritis TLR5 4.25891716239218 3.67063118712625 4.84720313765811 1.32053668444228 0.401124380056936 0.846017283399415 1 0.0405714 0.00761879 0.0464148 0.0288769 GeneID:7100,Genbank:XM_006711505.3,HGNC:HGNC:11851,MIM:603031 toll like receptor 5 GO:0002755,GO:0004888,GO:0005149,GO:0005886,GO:0006954,GO:0008584,GO:0016021,GO:0032757,GO:0034123,GO:0034146,GO:0042742,GO:0045087,GO:0045429,GO:0050707,GO:0071222,GO:0071260 MyD88-dependent toll-like receptor signaling pathway|transmembrane signaling receptor activity|interleukin-1 receptor binding|plasma membrane|inflammatory response|male gonad development|integral component of membrane|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|defense response to bacterium|innate immune response|positive regulation of nitric oxide biosynthetic process|regulation of cytokine secretion|cellular response to lipopolysaccharide|cellular response to mechanical stimulus hsa04620,hsa05130,hsa05132,hsa05134,hsa05321 Toll-like receptor signaling pathway|Pathogenic Escherichia coli infection|Salmonella infection|Legionellosis|Inflammatory bowel disease (IBD) TLR6 84.1073644153434 64.9569483954108 103.257780435276 1.58963410360224 0.668694729241524 0.318476484872832 1 0.453324 0.26971 0.725159 0.368401 GeneID:10333,Genbank:XM_011513614.3,HGNC:HGNC:16711,MIM:605403 toll like receptor 6 GO:0001774,GO:0001775,GO:0002224,GO:0002755,GO:0004872,GO:0004888,GO:0005102,GO:0005622,GO:0005794,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007165,GO:0007250,GO:0010628,GO:0030670,GO:0034136,GO:0034150,GO:0035355,GO:0035663,GO:0035666,GO:0038124,GO:0042088,GO:0042496,GO:0042742,GO:0042802,GO:0043032,GO:0043123,GO:0043235,GO:0043507,GO:0045087,GO:0045121,GO:0045410,GO:0045429,GO:0046209,GO:0046982,GO:0050702,GO:0051092,GO:0071723,GO:0071726,GO:0140052,GO:1900017,GO:1900227,GO:1903223,GO:1903428,GO:1904646,GO:2000483 microglial cell activation|cell activation|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|receptor activity|transmembrane signaling receptor activity|receptor binding|intracellular|Golgi apparatus|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|signal transduction|activation of NF-kappaB-inducing kinase activity|positive regulation of gene expression|phagocytic vesicle membrane|negative regulation of toll-like receptor 2 signaling pathway|toll-like receptor 6 signaling pathway|Toll-like receptor 2-Toll-like receptor 6 protein complex|Toll-like receptor 2 binding|TRIF-dependent toll-like receptor signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|T-helper 1 type immune response|detection of diacyl bacterial lipopeptide|defense response to bacterium|identical protein binding|positive regulation of macrophage activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|receptor complex|positive regulation of JUN kinase activity|innate immune response|membrane raft|positive regulation of interleukin-6 biosynthetic process|positive regulation of nitric oxide biosynthetic process|nitric oxide metabolic process|protein heterodimerization activity|interleukin-1 beta secretion|positive regulation of NF-kappaB transcription factor activity|lipopeptide binding|cellular response to diacyl bacterial lipopeptide|cellular response to oxidised low-density lipoprotein particle stimulus|positive regulation of cytokine production involved in inflammatory response|positive regulation of NLRP3 inflammasome complex assembly|positive regulation of oxidative stress-induced neuron death|positive regulation of reactive oxygen species biosynthetic process|cellular response to amyloid-beta|negative regulation of interleukin-8 secretion hsa04145,hsa04620,hsa05142,hsa05152 Phagosome|Toll-like receptor signaling pathway|Chagas disease (American trypanosomiasis)|Tuberculosis TLR7 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.00801495 0 0 0.00719216 GeneID:51284,Genbank:NM_016562.3,HGNC:HGNC:15631,MIM:300365 toll like receptor 7 GO:0000139,GO:0001774,GO:0001932,GO:0002224,GO:0002755,GO:0003725,GO:0003727,GO:0004888,GO:0005737,GO:0005764,GO:0005768,GO:0005783,GO:0005789,GO:0005886,GO:0006954,GO:0007252,GO:0008144,GO:0010008,GO:0016021,GO:0032009,GO:0032722,GO:0032755,GO:0032757,GO:0034154,GO:0034162,GO:0035197,GO:0036020,GO:0042346,GO:0043235,GO:0045078,GO:0045087,GO:0045356,GO:0045359,GO:0045416,GO:0050729,GO:0051607,GO:0071260 Golgi membrane|microglial cell activation|regulation of protein phosphorylation|toll-like receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|double-stranded RNA binding|single-stranded RNA binding|transmembrane signaling receptor activity|cytoplasm|lysosome|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|inflammatory response|I-kappaB phosphorylation|drug binding|endosome membrane|integral component of membrane|early phagosome|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|toll-like receptor 7 signaling pathway|toll-like receptor 9 signaling pathway|siRNA binding|endolysosome membrane|positive regulation of NF-kappaB import into nucleus|receptor complex|positive regulation of interferon-gamma biosynthetic process|innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of inflammatory response|defense response to virus|cellular response to mechanical stimulus hsa04620,hsa05162,hsa05164 Toll-like receptor signaling pathway|Measles|Influenza A TLR9 3.45090067537533 2.05633815719933 4.84546319355132 2.35635524078913 1.23655705423232 0.511332323665511 1 0.0299117 0.0256683 0.0549909 0.0768036 GeneID:54106,Genbank:NM_017442.3,HGNC:HGNC:15633,MIM:605474 toll like receptor 9 GO:0000139,GO:0002224,GO:0002237,GO:0002639,GO:0002755,GO:0004888,GO:0005149,GO:0005576,GO:0005578,GO:0005615,GO:0005737,GO:0005764,GO:0005768,GO:0005783,GO:0005789,GO:0005886,GO:0006954,GO:0007252,GO:0007409,GO:0010008,GO:0010628,GO:0016021,GO:0016303,GO:0016323,GO:0016324,GO:0030277,GO:0030890,GO:0032009,GO:0032088,GO:0032640,GO:0032715,GO:0032717,GO:0032722,GO:0032725,GO:0032728,GO:0032733,GO:0032735,GO:0032741,GO:0032755,GO:0032757,GO:0032760,GO:0034122,GO:0034123,GO:0034162,GO:0034163,GO:0035197,GO:0036020,GO:0042346,GO:0042742,GO:0042803,GO:0043123,GO:0043410,GO:0043507,GO:0045078,GO:0045087,GO:0045322,GO:0045356,GO:0045359,GO:0045577,GO:0045944,GO:0046330,GO:0050707,GO:0050729,GO:0050829,GO:0050871,GO:0051092,GO:0051770,GO:1901895 Golgi membrane|toll-like receptor signaling pathway|response to molecule of bacterial origin|positive regulation of immunoglobulin production|MyD88-dependent toll-like receptor signaling pathway|transmembrane signaling receptor activity|interleukin-1 receptor binding|extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|lysosome|endosome|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|inflammatory response|I-kappaB phosphorylation|axonogenesis|endosome membrane|positive regulation of gene expression|integral component of membrane|1-phosphatidylinositol-3-kinase activity|basolateral plasma membrane|apical plasma membrane|maintenance of gastrointestinal epithelium|positive regulation of B cell proliferation|early phagosome|negative regulation of NF-kappaB transcription factor activity|tumor necrosis factor production|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|positive regulation of chemokine production|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of interferon-beta production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of tumor necrosis factor production|negative regulation of toll-like receptor signaling pathway|positive regulation of toll-like receptor signaling pathway|toll-like receptor 9 signaling pathway|regulation of toll-like receptor 9 signaling pathway|siRNA binding|endolysosome membrane|positive regulation of NF-kappaB import into nucleus|defense response to bacterium|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|positive regulation of JUN kinase activity|positive regulation of interferon-gamma biosynthetic process|innate immune response|unmethylated CpG binding|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|regulation of B cell differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of JNK cascade|regulation of cytokine secretion|positive regulation of inflammatory response|defense response to Gram-negative bacterium|positive regulation of B cell activation|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|negative regulation of calcium-transporting ATPase activity hsa04620,hsa05142,hsa05143,hsa05144,hsa05152,hsa05162,hsa05168 Toll-like receptor signaling pathway|Chagas disease (American trypanosomiasis)|African trypanosomiasis|Malaria|Tuberculosis|Measles|Herpes simplex infection TLX2 25.2791355318953 20.5153552973084 30.0429157664822 1.46441118523664 0.550320698164964 0.339059903501485 1 0.546279 0.543299 0.76378 0.822678 GeneID:3196,Genbank:NM_016170.4,HGNC:HGNC:5057,MIM:604240 T cell leukemia homeobox 2 GO:0001228,GO:0001707,GO:0005634,GO:0005737,GO:0043565,GO:0045944,GO:0048484,GO:0050774 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|mesoderm formation|nucleus|cytoplasm|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|enteric nervous system development|negative regulation of dendrite morphogenesis TM2D1 578.888534312037 618.881350077845 538.89571854623 0.870757728405365 -0.199656722386747 0.238970605906853 1 15.6282 15.7963 13.4069 12.2765 GeneID:83941,Genbank:NM_032027.2,HGNC:HGNC:24142,MIM:610080 TM2 domain containing 1 GO:0001540,GO:0004930,GO:0005654,GO:0005887,GO:0007186,GO:0097190 amyloid-beta binding|G-protein coupled receptor activity|nucleoplasm|integral component of plasma membrane|G-protein coupled receptor signaling pathway|apoptotic signaling pathway TM2D2 1479.59241998597 1498.0149555561 1461.16988441585 0.975404069896903 -0.0359281028213227 0.804464692555602 1 13.4353 13.9484 13.9482 13.3147 GeneID:83877,Genbank:NM_001024381.1,HGNC:HGNC:24127,MIM:610081 TM2 domain containing 2 GO:0016021 integral component of membrane TM2D3 635.443385205371 639.406514030262 631.480256380481 0.987603727087764 -0.0179958138533174 0.915491607103087 1 12.272 12.7089 13.4446 12.4423 GeneID:80213,Genbank:NM_001307960.1,HGNC:HGNC:24128,MIM:610014 TM2 domain containing 3 GO:0016021 integral component of membrane TM4SF1 2126.63809453796 1967.0041342216 2286.27205485431 1.16231176898825 0.216997097351901 0.205447393381085 1 39.2443 38.7339 44.7059 51.7043 GeneID:4071,Genbank:NM_014220.2,HGNC:HGNC:11853,MIM:191155 transmembrane 4 L six family member 1 GO:0005887 integral component of plasma membrane TM4SF18 116.152525655743 101.442746203464 130.862305108021 1.29001145972084 0.367383881779526 0.184782854451106 1 0.922034 0.899525 1.49675 1.09437 GeneID:116441,Genbank:NM_138786.3,HGNC:HGNC:25181 transmembrane 4 L six family member 18 GO:0016021 integral component of membrane TM4SF19 74.0553139830711 81.715428611331 66.3951993548113 0.81251729915793 -0.299529565374387 0.387582432168201 1 3.72875 2.65699 2.63722 2.766 GeneID:116211,Genbank:NM_001204898.1,HGNC:HGNC:25167 transmembrane 4 L six family member 19 GO:0016021 integral component of membrane TM4SF20 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:79853,Genbank:NM_024795.4,HGNC:HGNC:26230,MIM:615404 transmembrane 4 L six family member 20 GO:0005789,GO:0005886,GO:0005925,GO:0016021,GO:0045861 endoplasmic reticulum membrane|plasma membrane|focal adhesion|integral component of membrane|negative regulation of proteolysis TM6SF1 4.29337148450173 5.67894306964064 2.90779989936283 0.512031880528578 -0.965694455660922 0.562265164231363 1 0.036684 0 0.0211489 0 GeneID:53346,Genbank:NM_001353882.1,HGNC:HGNC:11860,MIM:606562 transmembrane 6 superfamily member 1 GO:0005765,GO:0016021 lysosomal membrane|integral component of membrane TM7SF2 448.490873620171 404.167517439894 492.814229800449 1.21933161012559 0.286090535493122 0.233178537510172 1 14.2859 16.3205 16.391 21.2258 GeneID:7108,Genbank:NM_003273.3,HGNC:HGNC:11863,MIM:603414 transmembrane 7 superfamily member 2 GO:0005783,GO:0005789,GO:0005887,GO:0006695,GO:0016126,GO:0016627,GO:0030176,GO:0031090,GO:0043231,GO:0043235,GO:0045540,GO:0050613,GO:0050661 endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|cholesterol biosynthetic process|sterol biosynthetic process|oxidoreductase activity, acting on the CH-CH group of donors|integral component of endoplasmic reticulum membrane|organelle membrane|intracellular membrane-bounded organelle|receptor complex|regulation of cholesterol biosynthetic process|delta14-sterol reductase activity|NADP binding hsa00100 Steroid biosynthesis TM7SF3 2152.27917582202 2063.65304461083 2240.90530703322 1.08589247251871 0.118881251351863 0.399620886903737 1 6.69564 7.17287 7.8584 7.4334 GeneID:51768,Genbank:XM_017019463.2,HGNC:HGNC:23049,MIM:605181 transmembrane 7 superfamily member 3 GO:0005886,GO:0016021,GO:0032024,GO:0034620,GO:0043069,GO:0070062 plasma membrane|integral component of membrane|positive regulation of insulin secretion|cellular response to unfolded protein|negative regulation of programmed cell death|extracellular exosome TM9SF1 2054.52707830611 1882.67566946707 2226.37848714515 1.1825608219473 0.241914386748745 0.0855566785970617 0.964561165794104 26.8052 27.5851 34.0243 32.6641 GeneID:10548,Genbank:NM_001289006.1,HGNC:HGNC:11864 transmembrane 9 superfamily member 1 GO:0000421,GO:0005765,GO:0006914,GO:0016021,GO:0031410 autophagosome membrane|lysosomal membrane|autophagy|integral component of membrane|cytoplasmic vesicle TM9SF2 3954.34368669117 3895.85913432968 4012.82823905266 1.03002395638288 0.0426778921200077 0.741729684238263 1 53.6172 54.2318 58.5239 52.7114 GeneID:9375,Genbank:NM_004800.2,HGNC:HGNC:11865,MIM:604678 transmembrane 9 superfamily member 2 GO:0005768,GO:0005887,GO:0006810,GO:0010008,GO:0070062 endosome|integral component of plasma membrane|transport|endosome membrane|extracellular exosome TM9SF3 2933.14187156784 3012.4461054002 2853.83763773549 0.947348944307957 -0.0780321723648391 0.753698677432932 1 19.8087 16.7796 20.305 14.8289 GeneID:56889,Genbank:NM_020123.3,HGNC:HGNC:21529,MIM:616872 transmembrane 9 superfamily member 3 GO:0016021 integral component of membrane TM9SF4 3081.75767168109 2975.5321391234 3187.98320423879 1.0713993515049 0.0994963279380147 0.457762948652288 1 25.0606 23.6174 28.4592 25.2806 GeneID:9777,Genbank:NM_014742.3,HGNC:HGNC:30797,MIM:617727 transmembrane 9 superfamily member 4 GO:0001666,GO:0005769,GO:0005794,GO:0006909,GO:0007155,GO:0016021,GO:0051453,GO:0070072,GO:0070863,GO:2000010 response to hypoxia|early endosome|Golgi apparatus|phagocytosis|cell adhesion|integral component of membrane|regulation of intracellular pH|vacuolar proton-transporting V-type ATPase complex assembly|positive regulation of protein exit from endoplasmic reticulum|positive regulation of protein localization to cell surface TMA16 393.578785516522 470.190852533481 316.966718499563 0.674123532586148 -0.568915106567609 0.00211123198870059 0.164715617601136 10.3236 11.7305 7.91513 6.58915 GeneID:55319,Genbank:NM_018352.2,HGNC:HGNC:25638 translation machinery associated 16 homolog GO:0005634,GO:0005730 nucleus|nucleolus TMA7 4558.88190200281 4648.03416508824 4469.72963891738 0.961638722987424 -0.0564331036457485 0.765727672809307 1 350.935 395.16 330.479 397.935 GeneID:51372,Genbank:NM_015933.5,HGNC:HGNC:26932,MIM:615808 translation machinery associated 7 homolog TMBIM1 2164.9969120195 2035.32597284752 2294.66785119148 1.12742031586278 0.173025469869047 0.220566525623158 1 22.2247 22.5149 25.4217 25.6689 GeneID:64114,Genbank:NM_001321435.1,HGNC:HGNC:23410,MIM:610364 transmembrane BAX inhibitor motif containing 1 GO:0005123,GO:0005765,GO:0005794,GO:0005886,GO:0010008,GO:0016021,GO:0035579,GO:0043086,GO:0043231,GO:0043312,GO:0070062,GO:1902042,GO:1902045,GO:1903077,GO:2000504 death receptor binding|lysosomal membrane|Golgi apparatus|plasma membrane|endosome membrane|integral component of membrane|specific granule membrane|negative regulation of catalytic activity|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of Fas signaling pathway|negative regulation of protein localization to plasma membrane|positive regulation of blood vessel remodeling TMBIM4 677.965688039856 687.644216830184 668.287159249528 0.971850184867568 -0.0411941619277539 0.797538675825887 1 10.5043 11.8451 10.8656 11.7624 GeneID:51643,Genbank:NM_001282610.1,HGNC:HGNC:24257,MIM:616874 transmembrane BAX inhibitor motif containing 4 GO:0000139,GO:0005795,GO:0006915,GO:0016021,GO:0043066,GO:0050848 Golgi membrane|Golgi stack|apoptotic process|integral component of membrane|negative regulation of apoptotic process|regulation of calcium-mediated signaling TMBIM6 17339.7766403941 17039.8045767162 17639.748704072 1.03520839248213 0.0499212184856356 0.700618600715011 1 189.027 192.362 206.701 191.493 GeneID:7009,Genbank:NM_003217.2,HGNC:HGNC:11723,MIM:600748 transmembrane BAX inhibitor motif containing 6 GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005887,GO:0006914,GO:0006986,GO:0010523,GO:0016020,GO:0016021,GO:0019899,GO:0031625,GO:0031966,GO:0032091,GO:0032469,GO:0043066,GO:0051025,GO:0060698,GO:0060702,GO:0070059,GO:1902065,GO:1902236,GO:1903298,GO:1904721,GO:1990441,GO:2001234 nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of plasma membrane|autophagy|response to unfolded protein|negative regulation of calcium ion transport into cytosol|membrane|integral component of membrane|enzyme binding|ubiquitin protein ligase binding|mitochondrial membrane|negative regulation of protein binding|endoplasmic reticulum calcium ion homeostasis|negative regulation of apoptotic process|negative regulation of immunoglobulin secretion|endoribonuclease inhibitor activity|negative regulation of endoribonuclease activity|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|response to L-glutamate|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway|negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|negative regulation of apoptotic signaling pathway TMC1 6.07185119624453 7.78330750152491 4.36039489096415 0.560223900971387 -0.835924560105201 0.533747077844079 1 0.0201468 0.0192373 0.0193996 0 GeneID:117531,Genbank:NM_138691.2,HGNC:HGNC:16513,MIM:606706 transmembrane channel like 1 GO:0005245,GO:0009897,GO:0016021,GO:0032426,GO:0050910,GO:0060005,GO:0060117,GO:1903169 voltage-gated calcium channel activity|external side of plasma membrane|integral component of membrane|stereocilium tip|detection of mechanical stimulus involved in sensory perception of sound|vestibular reflex|auditory receptor cell development|regulation of calcium ion transmembrane transport TMC3 1.24168699318059 1.02816907859967 1.45520490776151 1.41533619134263 0.501144783780499 1 1 0 0 0 0 GeneID:342125,Genbank:NM_001080532.2,HGNC:HGNC:22995,MIM:617196 transmembrane channel like 3 GO:0006811,GO:0016021 ion transport|integral component of membrane TMC4 3.23150968937081 2.10436443188427 4.35865494685735 2.07124530372078 1.05049842632715 0.62665766861885 1 0.0511394 0.022289 0 0.0885294 GeneID:147798,Genbank:NM_144686.3,HGNC:HGNC:22998,MIM:617181 transmembrane channel like 4 GO:0006811,GO:0016021,GO:0070062 ion transport|integral component of membrane|extracellular exosome TMC6 19.4779905639932 23.4459750539446 15.5100060740419 0.661521051624272 -0.596141026681696 0.386466726687277 1 0.447127 0.16127 0.157468 0.117726 GeneID:11322,Genbank:NM_007267.7,HGNC:HGNC:18021,MIM:605828 transmembrane channel like 6 TMC7 106.166928216199 103.749024389196 108.584832043201 1.04661063255751 0.0657248205338948 0.883927383980822 1 0.787645 0.747776 0.982434 0.519666 GeneID:79905,Genbank:NM_024847.4,HGNC:HGNC:23000,MIM:617198 transmembrane channel like 7 GO:0006811,GO:0016021 ion transport|integral component of membrane TMCC1 583.605071129528 602.564914989197 564.645227269859 0.937069539271104 -0.0937719816464522 0.589027095014401 1 2.87478 2.71733 3.00759 2.23501 GeneID:23023,Genbank:XM_017005933.1,HGNC:HGNC:29116,MIM:616242 transmembrane and coiled-coil domain family 1 GO:0005789,GO:0005791,GO:0005829,GO:0007029,GO:0016021,GO:0042803,GO:0046982,GO:0051260,GO:0051291 endoplasmic reticulum membrane|rough endoplasmic reticulum|cytosol|endoplasmic reticulum organization|integral component of membrane|protein homodimerization activity|protein heterodimerization activity|protein homooligomerization|protein heterooligomerization TMCC2 593.791510954696 533.822682547929 653.760339361462 1.22467695872545 0.292401250039305 0.0866378551679249 0.964945680368209 3.59104 3.94217 4.75705 4.54192 GeneID:9911,Genbank:NM_014858.3,HGNC:HGNC:24239 transmembrane and coiled-coil domain family 2 GO:0005783,GO:0016021,GO:0042982 endoplasmic reticulum|integral component of membrane|amyloid precursor protein metabolic process TMCC3 60.9286517322159 63.7082652536023 58.1490382108294 0.912739312228274 -0.131725224446094 0.720144715230798 1 0.335957 0.459812 0.347252 0.412428 GeneID:57458,Genbank:NM_020698.3,HGNC:HGNC:29199,MIM:617459 transmembrane and coiled-coil domain family 3 GO:0016021 integral component of membrane TMCO1 2605.29274988394 2681.82279222265 2528.76270754523 0.942926846202777 -0.0847822462715062 0.538838885955783 1 17.3604 18.3166 17.1572 16.615 GeneID:54499,Genbank:NM_001256164.1,HGNC:HGNC:18188,MIM:614123 transmembrane and coiled-coil domains 1 GO:0000139,GO:0005262,GO:0005783,GO:0006983,GO:0030176,GO:0032469,GO:0070588 Golgi membrane|calcium channel activity|endoplasmic reticulum|ER overload response|integral component of endoplasmic reticulum membrane|endoplasmic reticulum calcium ion homeostasis|calcium ion transmembrane transport TMCO3 2323.02793437315 2163.28939268562 2482.76647606068 1.14768115835785 0.198721897112903 0.154431956116151 1 5.75361 5.86156 7.23259 6.42879 GeneID:55002,Genbank:NM_017905.5,HGNC:HGNC:20329,MIM:617134 transmembrane and coiled-coil domains 3 GO:0015299,GO:0016020,GO:0016021,GO:0022890 solute:proton antiporter activity|membrane|integral component of membrane|inorganic cation transmembrane transporter activity TMCO4 527.081845777835 560.314947218096 493.848744337574 0.881377066218706 -0.182168737281543 0.2782966990684 1 2.36308 2.51597 2.33314 2.1705 GeneID:255104,Genbank:XM_011541186.2,HGNC:HGNC:27393 transmembrane and coiled-coil domains 4 GO:0016021 integral component of membrane TMCO6 203.956347026242 216.521247767473 191.39144628501 0.883938404468043 -0.177982253171748 0.570971299659241 1 0.340989 0.418832 0.552631 0.485758 GeneID:55374,Genbank:XM_011537665.2,HGNC:HGNC:28814 transmembrane and coiled-coil domains 6 GO:0005634,GO:0005737,GO:0006606,GO:0008565,GO:0016021 nucleus|cytoplasm|protein import into nucleus|protein transporter activity|integral component of membrane TMED1 1419.9915665651 1396.3801042539 1443.6030288763 1.03381810187538 0.0479823688178169 0.748366139530124 1 24.1564 24.3089 24.9384 28.0074 GeneID:11018,Genbank:NM_006858.3,HGNC:HGNC:17291,MIM:605395 transmembrane p24 trafficking protein 1 GO:0005102,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005886,GO:0007165,GO:0007267,GO:0015031,GO:0016021,GO:0033116 receptor binding|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|plasma membrane|signal transduction|cell-cell signaling|protein transport|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane TMED10 3706.81008685398 3531.11784310959 3882.50233059837 1.09951083569031 0.136861822037026 0.301751930781518 1 39.3609 38.3317 46.2249 40.1227 GeneID:10972,Genbank:NM_006827.5,HGNC:HGNC:16998,MIM:605406 transmembrane p24 trafficking protein 10 GO:0000139,GO:0001822,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0005801,GO:0005886,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0012507,GO:0016021,GO:0019905,GO:0030133,GO:0030137,GO:0030140,GO:0030667,GO:0032403,GO:0033116,GO:0035459,GO:0035964,GO:0042470,GO:0042589,GO:0043279,GO:0045055,GO:0048199,GO:0048205,GO:0048208,GO:0051259,GO:0070062,GO:0070765,GO:1902003 Golgi membrane|kidney development|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|plasma membrane|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|Golgi organization|ER to Golgi transport vesicle membrane|integral component of membrane|syntaxin binding|transport vesicle|COPI-coated vesicle|trans-Golgi network transport vesicle|secretory granule membrane|protein complex binding|endoplasmic reticulum-Golgi intermediate compartment membrane|cargo loading into vesicle|COPI-coated vesicle budding|melanosome|zymogen granule membrane|response to alkaloid|regulated exocytosis|vesicle targeting, to, from or within Golgi|COPI coating of Golgi vesicle|COPII vesicle coating|protein oligomerization|extracellular exosome|gamma-secretase complex|regulation of amyloid-beta formation TMED2 4966.19032154087 4924.09382251254 5008.2868205692 1.01709817097142 0.0244589357718799 0.835425784129548 1 92.847 87.6976 96.6897 87.3285 GeneID:10959,Genbank:NM_006815.3,HGNC:HGNC:16996 transmembrane p24 trafficking protein 2 GO:0000139,GO:0001843,GO:0001893,GO:0001947,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006886,GO:0006888,GO:0006890,GO:0007030,GO:0010628,GO:0012507,GO:0016021,GO:0030133,GO:0030137,GO:0030663,GO:0032525,GO:0032580,GO:0033116,GO:0034260,GO:0035264,GO:0035459,GO:0036342,GO:0042589,GO:0043231,GO:0048205,GO:0048208,GO:0060716,GO:0072659 Golgi membrane|neural tube closure|maternal placenta development|heart looping|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|intracellular protein transport|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|Golgi organization|positive regulation of gene expression|ER to Golgi transport vesicle membrane|integral component of membrane|transport vesicle|COPI-coated vesicle|COPI-coated vesicle membrane|somite rostral/caudal axis specification|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|negative regulation of GTPase activity|multicellular organism growth|cargo loading into vesicle|post-anal tail morphogenesis|zymogen granule membrane|intracellular membrane-bounded organelle|COPI coating of Golgi vesicle|COPII vesicle coating|labyrinthine layer blood vessel development|protein localization to plasma membrane TMED3 3758.69213500255 3692.84343975723 3824.54083024787 1.03566286863743 0.0505544500324511 0.723470929248851 1 16.0356 17.7007 17.4263 17.9869 GeneID:23423,Genbank:NM_001330376.1,HGNC:HGNC:28889 transmembrane p24 trafficking protein 3 GO:0000139,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006888,GO:0006890,GO:0015031,GO:0016021,GO:0030126,GO:0030133,GO:0032580,GO:0033116 Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|protein transport|integral component of membrane|COPI vesicle coat|transport vesicle|Golgi cisterna membrane|endoplasmic reticulum-Golgi intermediate compartment membrane TMED4 4296.61312749094 4352.3614815771 4240.86477340478 0.974382479799927 -0.0374399022558054 0.767195753047845 1 47.1537 48.3531 48.2689 48.1235 GeneID:222068,Genbank:NM_001303061.1,HGNC:HGNC:22301,MIM:612038 transmembrane p24 trafficking protein 4 GO:0004871,GO:0005789,GO:0015031,GO:0016021,GO:0043123,GO:0070062 signal transducer activity|endoplasmic reticulum membrane|protein transport|integral component of membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|extracellular exosome TMED5 1219.18484129968 1233.85971224854 1204.50997035081 0.976213064089564 -0.0347320362810326 0.920834746659156 1 7.79773 7.19256 8.99038 5.59451 GeneID:50999,Genbank:NM_016040.4,HGNC:HGNC:24251,MIM:616876 transmembrane p24 trafficking protein 5 GO:0005789,GO:0005793,GO:0005794,GO:0005801,GO:0015031,GO:0016021,GO:0033116,GO:0070971,GO:0090161 endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|cis-Golgi network|protein transport|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|endoplasmic reticulum exit site|Golgi ribbon formation TMED6 1.7789146977695 2.10436443188427 1.45346496365472 0.690690710046484 -0.533888275697058 0.969271251083323 1 0.0942756 0 0.0443003 0.0413515 GeneID:146456,Genbank:NM_144676.3,HGNC:HGNC:28331 transmembrane p24 trafficking protein 6 GO:0005789,GO:0016021 endoplasmic reticulum membrane|integral component of membrane TMED7 1240.61492782778 1277.2240929925 1204.00576266305 0.942673857523388 -0.0851693754390182 0.806787336200668 1 25.3323 21.834 27.0328 18.2144 GeneID:51014,Genbank:NM_181836.5,HGNC:HGNC:24253 transmembrane p24 trafficking protein 7 GO:0000139,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006888,GO:0006890,GO:0015031,GO:0016021,GO:0030126,GO:0030127,GO:0030133,GO:0033116,GO:0070062 Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|protein transport|integral component of membrane|COPI vesicle coat|COPII vesicle coat|transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|extracellular exosome TMED8 321.424325771184 343.802491104876 299.046160437493 0.869819644053334 -0.201211803815543 0.31252126896959 1 1.7794 1.70723 1.76868 1.36319 GeneID:283578,Genbank:NM_213601.2,HGNC:HGNC:18633 transmembrane p24 trafficking protein family member 8 TMED9 8379.74373724993 7618.21678741225 9141.27068708761 1.19992262522536 0.262941379331582 0.0465763603905661 0.79332376136203 113.186 121.99 142.354 144.561 GeneID:54732,Genbank:NM_017510.5,HGNC:HGNC:24878 transmembrane p24 trafficking protein 9 GO:0000139,GO:0005783,GO:0005789,GO:0005793,GO:0005794,GO:0006888,GO:0006890,GO:0007030,GO:0010638,GO:0015031,GO:0016021,GO:0019905,GO:0030133,GO:0030140,GO:0033116,GO:0048205,GO:0070062 Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|Golgi apparatus|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|Golgi organization|positive regulation of organelle organization|protein transport|integral component of membrane|syntaxin binding|transport vesicle|trans-Golgi network transport vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|COPI coating of Golgi vesicle|extracellular exosome TMEFF1 2.48457057796618 2.54640955915669 2.42273159677566 0.951430451579833 -0.0718298938037766 1 1 0.553345 1.06899 0.123604 0.246346 GeneID:8577,Genbank:NM_003692.4,HGNC:HGNC:11866,MIM:603421 transmembrane protein with EGF like and two follistatin like domains 1 GO:0005886,GO:0007275,GO:0016021 plasma membrane|multicellular organism development|integral component of membrane TMEFF2 12.4347073991532 14.2022620016556 10.6671527966508 0.751088298146259 -0.412945573553153 0.640791672588858 1 0.048869 0.0376048 0.0528347 0.00491261 GeneID:23671,Genbank:XM_017003739.2,HGNC:HGNC:11867,MIM:605734 transmembrane protein with EGF like and two follistatin like domains 2 GO:0005576,GO:0016021,GO:0030336,GO:0044319,GO:0045720,GO:0051497 extracellular region|integral component of membrane|negative regulation of cell migration|wound healing, spreading of cells|negative regulation of integrin biosynthetic process|negative regulation of stress fiber assembly TMEM100 4.29467644258183 5.67894306964064 2.91040981552302 0.512491458328212 -0.964400135401421 0.56222901680275 1 0.112348 0.0354463 0.0716842 0 GeneID:55273,Genbank:NM_001099640.1,HGNC:HGNC:25607,MIM:616334 transmembrane protein 100 GO:0001525,GO:0001570,GO:0001701,GO:0003198,GO:0005783,GO:0005886,GO:0007219,GO:0016021,GO:0030509,GO:0043204,GO:0043491,GO:0045603,GO:0048471,GO:0050848,GO:0051930,GO:0060842,GO:0071773,GO:2001214 angiogenesis|vasculogenesis|in utero embryonic development|epithelial to mesenchymal transition involved in endocardial cushion formation|endoplasmic reticulum|plasma membrane|Notch signaling pathway|integral component of membrane|BMP signaling pathway|perikaryon|protein kinase B signaling|positive regulation of endothelial cell differentiation|perinuclear region of cytoplasm|regulation of calcium-mediated signaling|regulation of sensory perception of pain|arterial endothelial cell differentiation|cellular response to BMP stimulus|positive regulation of vasculogenesis TMEM101 968.050133260731 929.582550915394 1006.51771560607 1.08276313342469 0.114717671746748 0.52033664308188 1 7.83399 9.22307 9.03801 9.74863 GeneID:84336,Genbank:XM_011525353.2,HGNC:HGNC:28653 transmembrane protein 101 GO:0004871,GO:0016021,GO:0043123 signal transducer activity|integral component of membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling TMEM102 206.158900490328 208.776157885525 203.541643095131 0.97492762179643 -0.0366329771033692 0.882038957999789 1 5.64962 5.56802 5.63692 5.54999 GeneID:284114,Genbank:NM_178518.2,HGNC:HGNC:26722,MIM:613936 transmembrane protein 102 GO:0005622,GO:0005739,GO:0005886,GO:0006915,GO:0007165,GO:0009986,GO:0010820,GO:0016021,GO:0034097,GO:0043234,GO:0045785,GO:0050730,GO:1901028,GO:2000406 intracellular|mitochondrion|plasma membrane|apoptotic process|signal transduction|cell surface|positive regulation of T cell chemotaxis|integral component of membrane|response to cytokine|protein complex|positive regulation of cell adhesion|regulation of peptidyl-tyrosine phosphorylation|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of T cell migration TMEM104 1592.68348840418 1490.03176830244 1695.33520850592 1.13778460605399 0.186227466968125 0.208418312321874 1 7.32874 8.24663 9.69302 8.07951 GeneID:54868,Genbank:NM_017728.3,HGNC:HGNC:25984 transmembrane protein 104 GO:0016021 integral component of membrane TMEM105 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0310002 0 0 0 GeneID:284186,Genbank:NM_178520.3,HGNC:HGNC:26794 transmembrane protein 105 GO:0016021 integral component of membrane TMEM106A 129.406667273799 114.386516408204 144.426818139394 1.26262100354545 0.336421655468117 0.220921071272217 1 0.815403 1.06196 1.27339 0.963817 GeneID:113277,Genbank:NM_001291586.1,HGNC:HGNC:28288 transmembrane protein 106A GO:0016020,GO:0016021,GO:0070062 membrane|integral component of membrane|extracellular exosome TMEM106B 696.386178396566 676.938064225421 715.834292567712 1.057459065161 0.0806018168844564 0.605534212743588 1 4.9543 4.3021 5.19888 4.46564 GeneID:54664,Genbank:NM_018374.3,HGNC:HGNC:22407,MIM:613413 transmembrane protein 106B GO:0005764,GO:0005765,GO:0005768,GO:0007040,GO:0007041,GO:0016021,GO:0031902,GO:0032418,GO:0048813,GO:0070062,GO:1900006 lysosome|lysosomal membrane|endosome|lysosome organization|lysosomal transport|integral component of membrane|late endosome membrane|lysosome localization|dendrite morphogenesis|extracellular exosome|positive regulation of dendrite development TMEM106C 4352.37395471371 4280.91793509666 4423.82997433076 1.03338350358516 0.0473757586007502 0.762420240042323 1 74.7765 79.0534 77.2464 84.7781 GeneID:79022,Genbank:NM_001143842.1,HGNC:HGNC:28775 transmembrane protein 106C GO:0005789,GO:0016020,GO:0016021 endoplasmic reticulum membrane|membrane|integral component of membrane TMEM107 133.979751866128 131.807555814605 136.15194791765 1.03296011428325 0.0467845484559288 0.908506405742759 1 2.31422 2.11538 1.72705 2.84401 GeneID:84314,Genbank:NM_001351280.1,HGNC:HGNC:28128,MIM:616183 transmembrane protein 107 GO:0016021,GO:0021532,GO:0035869,GO:0036038,GO:0042733,GO:0060271,GO:1904491,GO:1905515 integral component of membrane|neural tube patterning|ciliary transition zone|MKS complex|embryonic digit morphogenesis|cilium assembly|protein localization to ciliary transition zone|non-motile cilium assembly TMEM108 103.990275543824 98.4542915170353 109.526259570613 1.11245795264965 0.153750807854119 0.593402823988773 1 0.546855 0.455371 0.604258 0.580746 GeneID:66000,Genbank:NM_023943.3,HGNC:HGNC:28451,MIM:617361 transmembrane protein 108 GO:0005769,GO:0006898,GO:0008090,GO:0010008,GO:0014069,GO:0016021,GO:0021542,GO:0030054,GO:0030424,GO:0030425,GO:0031175,GO:0036477,GO:0045211,GO:0051388,GO:0097106,GO:0097484,GO:0098815,GO:1904115,GO:1990416 early endosome|receptor-mediated endocytosis|retrograde axonal transport|endosome membrane|postsynaptic density|integral component of membrane|dentate gyrus development|cell junction|axon|dendrite|neuron projection development|somatodendritic compartment|postsynaptic membrane|positive regulation of neurotrophin TRK receptor signaling pathway|postsynaptic density organization|dendrite extension|modulation of excitatory postsynaptic potential|axon cytoplasm|cellular response to brain-derived neurotrophic factor stimulus TMEM109 1780.36643454611 1813.08858139169 1747.64428770053 0.96390452492899 -0.0530378407899225 0.687422789235943 1 39.6131 43.5076 43.5912 37.8082 GeneID:79073,Genbank:NM_024092.2,HGNC:HGNC:28771 transmembrane protein 109 GO:0005244,GO:0005640,GO:0016021,GO:0033017,GO:0034765,GO:0042771,GO:0060548,GO:0070062,GO:0071480 voltage-gated ion channel activity|nuclear outer membrane|integral component of membrane|sarcoplasmic reticulum membrane|regulation of ion transmembrane transport|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of cell death|extracellular exosome|cellular response to gamma radiation TMEM11 1366.17655433816 1396.26646839602 1336.08664028031 0.956899467631818 -0.0635607325246708 0.639037616986243 1 44.3902 49.9468 45.0274 45.936 GeneID:8834,Genbank:NM_003876.2,HGNC:HGNC:16823 transmembrane protein 11 GO:0005739,GO:0005887,GO:0007005,GO:0031305 mitochondrion|integral component of plasma membrane|mitochondrion organization|integral component of mitochondrial inner membrane TMEM114 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0461977 0 GeneID:283953,Genbank:NM_001290098.1,HGNC:HGNC:33227,MIM:611579 transmembrane protein 114 GO:0016021,GO:0016324,GO:0016327 integral component of membrane|apical plasma membrane|apicolateral plasma membrane TMEM115 1887.71621386946 1790.90988978891 1984.52253795001 1.1081085370431 0.148099197438492 0.302917376866102 1 39.0017 39.2189 44.6678 44.5395 GeneID:11070,Genbank:NM_007024.4,HGNC:HGNC:30055,MIM:607069 transmembrane protein 115 GO:0000139,GO:0005634,GO:0005794,GO:0006486,GO:0006888,GO:0006890,GO:0008285,GO:0015031,GO:0016021,GO:0032580,GO:0042802 Golgi membrane|nucleus|Golgi apparatus|protein glycosylation|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|negative regulation of cell proliferation|protein transport|integral component of membrane|Golgi cisterna membrane|identical protein binding TMEM116 114.991971645953 108.813434543041 121.170508748865 1.11356202713128 0.15518192071429 0.662200637064535 1 0.58599 1.00913 1.02287 0.773187 GeneID:89894,Genbank:XM_011538948.3,HGNC:HGNC:25084 transmembrane protein 116 GO:0016021 integral component of membrane TMEM117 135.824795352123 150.016632926181 121.632957778064 0.810796479067199 -0.302588271059513 0.256236147760363 1 1.47784 1.33317 1.01315 1.24128 GeneID:84216,Genbank:XM_011538831.3,HGNC:HGNC:25308 transmembrane protein 117 GO:0005783,GO:0005886,GO:0016021,GO:0070059 endoplasmic reticulum|plasma membrane|integral component of membrane|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TMEM119 1.94984442306237 1.96028560782945 1.93940323829528 0.989347282125237 -0.0154510680841627 1 1 0 0.0579174 0.0460655 0.0143702 GeneID:338773,Genbank:NM_181724.2,HGNC:HGNC:27884 transmembrane protein 119 GO:0001649,GO:0005789,GO:0005886,GO:0007283,GO:0016021,GO:0030501,GO:0031214,GO:0033690,GO:0045669,GO:0048515,GO:1903012 osteoblast differentiation|endoplasmic reticulum membrane|plasma membrane|spermatogenesis|integral component of membrane|positive regulation of bone mineralization|biomineral tissue development|positive regulation of osteoblast proliferation|positive regulation of osteoblast differentiation|spermatid differentiation|positive regulation of bone development TMEM120A 920.814025694072 877.27038942065 964.357661967494 1.09927073066305 0.136546739958119 0.395880257036803 1 16.7574 18.6396 19.0662 20.364 GeneID:83862,Genbank:NM_001317803.1,HGNC:HGNC:21697,MIM:616550 transmembrane protein 120A GO:0005637,GO:0016020,GO:0016021,GO:0045444,GO:0051260,GO:0051291 nuclear inner membrane|membrane|integral component of membrane|fat cell differentiation|protein homooligomerization|protein heterooligomerization TMEM120B 762.258561254009 799.503940989447 725.013181518572 0.906828777630931 -0.141097920078334 0.364304555844623 1 3.66738 4.00852 3.6142 3.53107 GeneID:144404,Genbank:NM_001080825.2,HGNC:HGNC:32008,MIM:616551 transmembrane protein 120B GO:0005637,GO:0016021,GO:0045444,GO:0051291 nuclear inner membrane|integral component of membrane|fat cell differentiation|protein heterooligomerization TMEM121 38.8743912126895 43.8270601823061 33.9217222430728 0.773990363532704 -0.369612490494582 0.415623170946355 1 1.53993 1.75679 1.18963 1.33315 GeneID:80757,Genbank:NM_025268.3,HGNC:HGNC:20511 transmembrane protein 121 GO:0016021 integral component of membrane TMEM121B 16.746206043379 14.1062094522857 19.3862026344723 1.37430276361954 0.458699869843898 0.557799320094852 1 0.102356 0.22532 0.250552 0.212335 GeneID:27439,Genbank:NM_001163079.1,HGNC:HGNC:1844 transmembrane protein 121B TMEM123 1607.16546055486 1761.75046069573 1452.58046041398 0.824509766179001 -0.278391512644186 0.286474210549175 1 23.3294 19.0882 20.1626 15.3358 GeneID:114908,Genbank:NM_052932.2,HGNC:HGNC:30138,MIM:606356 transmembrane protein 123 GO:0004872,GO:0009897,GO:0016021,GO:0031410,GO:0070267 receptor activity|external side of plasma membrane|integral component of membrane|cytoplasmic vesicle|oncosis TMEM126A 317.683092246283 338.787124226571 296.579060265994 0.875414202777229 -0.191962304341912 0.322257396739622 1 19.4903 22.4054 18.0127 18.4739 GeneID:84233,Genbank:NM_032273.3,HGNC:HGNC:25382,MIM:612988 transmembrane protein 126A GO:0005739,GO:0005743,GO:0016021,GO:0021554 mitochondrion|mitochondrial inner membrane|integral component of membrane|optic nerve development TMEM126B 616.197796001727 664.485382423494 567.91020957996 0.854661704533954 -0.226574614971646 0.326864282672244 1 5.85178 5.85439 4.6578 6.20994 GeneID:55863,Genbank:NM_001193537.3,HGNC:HGNC:30883,MIM:615533 transmembrane protein 126B GO:0005739,GO:0005743,GO:0016021,GO:0032981 mitochondrion|mitochondrial inner membrane|integral component of membrane|mitochondrial respiratory chain complex I assembly TMEM127 1883.79704003347 1719.9848236749 2047.60925639205 1.19048100204579 0.251544597951369 0.0767981860937068 0.94157495521624 9.86646 10.1224 12.8533 11.5504 GeneID:55654,Genbank:XM_017004450.1,HGNC:HGNC:26038,MIM:613403 transmembrane protein 127 GO:0005737,GO:0005769,GO:0005886,GO:0007032,GO:0008285,GO:0016021,GO:0017137,GO:0032007 cytoplasm|early endosome|plasma membrane|endosome organization|negative regulation of cell proliferation|integral component of membrane|Rab GTPase binding|negative regulation of TOR signaling TMEM128 518.953078901277 536.310240176438 501.595917626115 0.935271937863981 -0.0965421936660522 0.594276487369121 1 7.11525 6.50571 6.75111 6.36621 GeneID:85013,Genbank:NM_001297552.1,HGNC:HGNC:28201 transmembrane protein 128 GO:0016021 integral component of membrane TMEM129 2051.85855831597 1893.32500414289 2210.39211248906 1.16746575873258 0.223380236931833 0.120612229855862 1 23.0266 25.7314 29.6023 29.0493 GeneID:92305,Genbank:XM_005248039.5,HGNC:HGNC:25137,MIM:615975 transmembrane protein 129 GO:0000209,GO:0005783,GO:0005789,GO:0006986,GO:0016021,GO:0016567,GO:0030433,GO:0030970,GO:0046872,GO:0061630,GO:1904264 protein polyubiquitination|endoplasmic reticulum|endoplasmic reticulum membrane|response to unfolded protein|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|retrograde protein transport, ER to cytosol|metal ion binding|ubiquitin protein ligase activity|ubiquitin protein ligase activity involved in ERAD pathway TMEM130 14.4111523748645 12.8281003451534 15.9942044045757 1.24681004780404 0.31824168652655 0.707291331236297 1 0.115115 0.151854 0.20096 0.150497 GeneID:222865,Genbank:NM_001134451.1,HGNC:HGNC:25429 transmembrane protein 130 GO:0000139,GO:0005794,GO:0005887 Golgi membrane|Golgi apparatus|integral component of plasma membrane TMEM131 653.611824724211 667.887473272727 639.336176175696 0.957251336131331 -0.0630303260969096 0.815145626966912 1 3.17483 3.16936 3.71494 2.33546 GeneID:23505,Genbank:XM_005263912.3,HGNC:HGNC:30366,MIM:615659 transmembrane protein 131 GO:0016020,GO:0016021 membrane|integral component of membrane TMEM131L 197.790400228967 209.94840578818 185.632394669755 0.884181015677932 -0.177586336484698 0.444840966259806 1 1.11072 1.11222 1.10924 0.853236 GeneID:23240,Genbank:XM_024453956.1,HGNC:HGNC:29146,MIM:616243 transmembrane 131 like GO:0005737,GO:0005783,GO:0005886,GO:0016021,GO:0016055,GO:0033088,GO:0090090 cytoplasm|endoplasmic reticulum|plasma membrane|integral component of membrane|Wnt signaling pathway|negative regulation of immature T cell proliferation in thymus|negative regulation of canonical Wnt signaling pathway TMEM132A 2272.90069352191 2267.59714906253 2278.20423798128 1.00467767783318 0.00673272809407544 0.981052108437132 1 15.3178 16.4734 16.0912 16.3528 GeneID:54972,Genbank:NM_017870.3,HGNC:HGNC:31092,MIM:617363 transmembrane protein 132A GO:0000139,GO:0005783,GO:0005788,GO:0005789,GO:0005794,GO:0016021,GO:0043687,GO:0044267,GO:0070062 Golgi membrane|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|Golgi apparatus|integral component of membrane|post-translational protein modification|cellular protein metabolic process|extracellular exosome TMEM132B 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.00435264 0 0 GeneID:114795,Genbank:XM_011537852.2,HGNC:HGNC:29397 transmembrane protein 132B GO:0016021 integral component of membrane TMEM134 248.078037127356 256.293466565173 239.862607689538 0.935890449741693 -0.0955884292497556 0.690995035397515 1 2.75147 3.43527 2.82731 3.32681 GeneID:80194,Genbank:NM_001078651.2,HGNC:HGNC:26142 transmembrane protein 134 GO:0016021,GO:0048471 integral component of membrane|perinuclear region of cytoplasm TMEM135 221.277018806415 232.692587031211 209.861450581619 0.901882837176372 -0.148988068505859 0.531120698160221 1 1.22242 1.01905 1.12944 0.911962 GeneID:65084,Genbank:NM_022918.3,HGNC:HGNC:26167,MIM:616360 transmembrane protein 135 GO:0005777,GO:0005778,GO:0005811,GO:0007031,GO:0009409,GO:0016021,GO:0031966,GO:0032094,GO:0090140 peroxisome|peroxisomal membrane|lipid droplet|peroxisome organization|response to cold|integral component of membrane|mitochondrial membrane|response to food|regulation of mitochondrial fission TMEM136 263.838593530019 257.734254805722 269.942932254316 1.04736924650469 0.0667701492291472 0.751404696401646 1 2.42948 2.42743 2.72055 2.31484 GeneID:219902,Genbank:NM_001198670.1,HGNC:HGNC:28280 transmembrane protein 136 GO:0016021 integral component of membrane TMEM138 626.107928043528 676.478435789642 575.737420297413 0.851080226416033 -0.232632962039331 0.158855704569843 1 4.86236 5.2901 4.49974 4.22899 GeneID:51524,Genbank:NM_016464.4,HGNC:HGNC:26944,MIM:614459 transmembrane protein 138 GO:0005774,GO:0005929,GO:0016021,GO:0060271 vacuolar membrane|cilium|integral component of membrane|cilium assembly TMEM139 4.26141871207728 4.16070258908361 4.36213483507094 1.04841303642222 0.0682071979861005 1 1 0.0691769 0.0469188 0.065242 0.0456966 GeneID:135932,Genbank:NM_001242774.2,HGNC:HGNC:22058,MIM:616524 transmembrane protein 139 GO:0016021 integral component of membrane TMEM140 257.803883670828 206.815872277696 308.79189506396 1.49307638559452 0.578287975451973 0.258594713647811 1 3.41991 3.81771 8.13572 3.75508 GeneID:55281,Genbank:NM_018295.4,HGNC:HGNC:21870 transmembrane protein 140 GO:0016021 integral component of membrane TMEM141 572.439539354006 519.774308025437 625.104770682576 1.20264653529582 0.266212688477492 0.252366536431003 1 21.0464 24.1897 25.46 31.2688 GeneID:85014,Genbank:NM_032928.3,HGNC:HGNC:28211 transmembrane protein 141 GO:0003341,GO:0005930,GO:0016021,GO:0036158 cilium movement|axoneme|integral component of membrane|outer dynein arm assembly TMEM143 92.4376143364112 88.9126121615287 95.9626165112937 1.07929138710892 0.110084416248025 0.728459945828164 1 1.656 1.43528 1.93244 1.56397 GeneID:55260,Genbank:NM_001303540.1,HGNC:HGNC:25603 transmembrane protein 143 GO:0005739,GO:0016021 mitochondrion|integral component of membrane TMEM144 92.9829011573424 91.4688303757933 94.4969719388914 1.03310572083033 0.0469878971006577 0.911069426708536 1 0.628151 0.906142 0.700264 0.792616 GeneID:55314,Genbank:XM_005263112.3,HGNC:HGNC:25633 transmembrane protein 144 GO:0015144,GO:0016021 carbohydrate transmembrane transporter activity|integral component of membrane TMEM145 8.33626918262789 9.88767193340919 6.7848664318466 0.686194533712369 -0.543310461585015 0.645032180700922 1 0.167713 0.141937 0.102667 0.119819 GeneID:284339,Genbank:XM_005258781.5,HGNC:HGNC:26912 transmembrane protein 145 GO:0007186,GO:0016021,GO:0019236 G-protein coupled receptor signaling pathway|integral component of membrane|response to pheromone TMEM147 2655.49142220279 2701.38946468308 2609.5933797225 0.966018937231864 -0.0498766238566363 0.698738589513007 1 118.436 121.526 118.52 123.33 GeneID:10430,Genbank:NM_001242597.1,HGNC:HGNC:30414,MIM:613585 transmembrane protein 147 GO:0005789,GO:0016021,GO:0031648 endoplasmic reticulum membrane|integral component of membrane|protein destabilization TMEM14A 685.180314040365 666.234962623223 704.125665457508 1.05687288263152 0.0798018643028485 0.628135814756519 1 39.0947 41.9566 41.6251 44.6469 GeneID:28978,Genbank:NM_014051.3,HGNC:HGNC:21076,MIM:616870 transmembrane protein 14A GO:0005789,GO:0006915,GO:0016021,GO:0031966,GO:0043066,GO:1901029 endoplasmic reticulum membrane|apoptotic process|integral component of membrane|mitochondrial membrane|negative regulation of apoptotic process|negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway TMEM14B 1919.88359893065 2180.63501385373 1659.13218400757 0.76084818113393 -0.394319486330793 0.07587338750974 0.94157495521624 52.6997 59.9928 37.5831 49.2936 GeneID:81853,Genbank:NM_001286488.1,HGNC:HGNC:21384 transmembrane protein 14B GO:0016021 integral component of membrane TMEM14C 2868.71012034255 3011.55053384227 2725.86970684282 0.905138292122575 -0.143789862782934 0.284138658469179 1 116.31 124.587 105.488 115.852 GeneID:51522,Genbank:NM_001165258.1,HGNC:HGNC:20952,MIM:615318 transmembrane protein 14C GO:0006783,GO:0016021,GO:0031966 heme biosynthetic process|integral component of membrane|mitochondrial membrane TMEM150A 93.0043671180891 111.388253066667 74.6204811695116 0.669913380586469 -0.577953526894527 0.0604561830592658 0.880242025342909 1.40865 1.32411 0.714202 1.05842 GeneID:129303,Genbank:NM_001031738.2,HGNC:HGNC:24677,MIM:616757 transmembrane protein 150A GO:0005764,GO:0005887,GO:0009056,GO:0046854,GO:0072659 lysosome|integral component of plasma membrane|catabolic process|phosphatidylinositol phosphorylation|protein localization to plasma membrane TMEM150B 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0129207 0.011471 0 0 GeneID:284417,Genbank:XM_011526850.3,HGNC:HGNC:34415,MIM:617291 transmembrane protein 150B GO:0000421,GO:0005764,GO:0005887,GO:0006914,GO:0010008 autophagosome membrane|lysosome|integral component of plasma membrane|autophagy|endosome membrane TMEM150C 44.5360777198627 33.8335270444191 55.2386283953064 1.63265947185421 0.707223915518552 0.100234823667239 1 0.314473 0.369811 0.488333 0.627569 GeneID:441027,Genbank:NM_001353454.1,HGNC:HGNC:37263,MIM:617292 transmembrane protein 150C GO:0005765,GO:0005887,GO:0008381,GO:0019230,GO:0071260 lysosomal membrane|integral component of plasma membrane|mechanosensitive ion channel activity|proprioception|cellular response to mechanical stimulus TMEM151A 1.82944252213953 2.69048838321152 0.968396661067546 0.35993341101574 -1.47419806745255 0.720084971607816 1 0.131593 0 0 0.0449585 GeneID:256472,Genbank:NM_153266.3,HGNC:HGNC:28497 transmembrane protein 151A GO:0016021 integral component of membrane TMEM151B 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0100076 GeneID:441151,Genbank:NM_001137560.1,HGNC:HGNC:21315 transmembrane protein 151B GO:0016021 integral component of membrane TMEM154 183.524921328615 187.712896256467 179.336946400763 0.955378932280391 -0.0658550315905591 0.801798245443838 1 1.19252 1.19772 1.36658 0.949527 GeneID:201799,Genbank:NM_152680.2,HGNC:HGNC:26489 transmembrane protein 154 GO:0016021 integral component of membrane TMEM156 1.21430233409962 0.490071401957362 1.93853326624189 3.95561393400904 1.98390162663545 0.683537482026705 1 0 0 0 0 GeneID:80008,Genbank:XM_011513753.2,HGNC:HGNC:26260 transmembrane protein 156 GO:0016021 integral component of membrane TMEM158 769.178694415933 856.948156222936 681.409232608931 0.795158059050262 -0.330686431543412 0.119287727220456 1 42.4239 51.2793 40.4535 36.4586 GeneID:25907,Genbank:NM_015444.2,HGNC:HGNC:30293 transmembrane protein 158 (gene/pseudogene) GO:0016021,GO:0042277 integral component of membrane|peptide binding TMEM159 89.7603953072035 86.4720638068498 93.0487268075571 1.07605534910555 0.105752287770361 0.75870998563085 1 0.807952 0.844155 1.09683 1.37207 GeneID:57146,Genbank:XM_006721066.2,HGNC:HGNC:30136,MIM:611304 transmembrane protein 159 GO:0016021 integral component of membrane TMEM160 470.293401290309 512.26055786266 428.326244717957 0.836149178662304 -0.258167736174069 0.478511776548718 1 14.7927 19.8319 11.8617 17.3425 GeneID:54958,Genbank:XM_017026917.1,HGNC:HGNC:26042 transmembrane protein 160 GO:0005739,GO:0016021 mitochondrion|integral component of membrane TMEM161A 614.593239224019 624.877876760919 604.308601687119 0.967082727939703 -0.0482887862779774 0.766321374994035 1 14.7448 14.7207 14.3233 13.8137 GeneID:54929,Genbank:NM_001256766.1,HGNC:HGNC:26020 transmembrane protein 161A GO:0016021,GO:0032526,GO:0034599,GO:0034644,GO:0045739,GO:1902230 integral component of membrane|response to retinoic acid|cellular response to oxidative stress|cellular response to UV|positive regulation of DNA repair|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage TMEM161B 502.286935354015 542.729194676569 461.844676031462 0.850967076327432 -0.232824779354488 0.187413847794231 1 1.00544 0.986091 0.852818 0.834621 GeneID:153396,Genbank:XM_024454372.1,HGNC:HGNC:28483 transmembrane protein 161B GO:0016021 integral component of membrane TMEM163 34.0866828114585 31.3351437599474 36.8382218629696 1.17562000497525 0.233421813976869 0.649602563556852 1 0.230473 0.224124 0.372513 0.224242 GeneID:81615,Genbank:XM_011511950.2,HGNC:HGNC:25380 transmembrane protein 163 GO:0008270,GO:0030054,GO:0030285,GO:0031901 zinc ion binding|cell junction|integral component of synaptic vesicle membrane|early endosome membrane TMEM164 692.215290373476 582.828805742811 801.601775004141 1.37536402989297 0.459813520173739 0.00508344398433529 0.283382242931613 1.93823 2.08945 2.98171 2.67815 GeneID:84187,Genbank:XM_017029898.1,HGNC:HGNC:26217 transmembrane protein 164 GO:0016021 integral component of membrane TMEM165 3430.40248785899 3561.53271299712 3299.27226272085 0.926363037655333 -0.110350404659513 0.415085946099041 1 40.8323 41.9853 37.9126 38.9278 GeneID:55858,Genbank:NM_018475.4,HGNC:HGNC:30760,MIM:614726 transmembrane protein 165 GO:0005765,GO:0005794,GO:0006487,GO:0006874,GO:0010008,GO:0016021,GO:0031901,GO:0031902,GO:0032472,GO:0032588,GO:0035751,GO:0043231 lysosomal membrane|Golgi apparatus|protein N-linked glycosylation|cellular calcium ion homeostasis|endosome membrane|integral component of membrane|early endosome membrane|late endosome membrane|Golgi calcium ion transport|trans-Golgi network membrane|regulation of lysosomal lumen pH|intracellular membrane-bounded organelle TMEM167A 1735.14157944537 1826.36345051495 1643.91970837579 0.900105457055813 -0.151834056268893 0.305036761467605 1 19.921 18.0827 18.2157 15.9938 GeneID:153339,Genbank:NM_174909.4,HGNC:HGNC:28330 transmembrane protein 167A GO:0000139,GO:0009306,GO:0012505,GO:0016021,GO:0046907 Golgi membrane|protein secretion|endomembrane system|integral component of membrane|intracellular transport TMEM167B 570.380805584577 533.513890588749 607.247720580404 1.13820414293298 0.186759335837778 0.26004543825526 1 7.85557 7.51064 9.13476 8.16464 GeneID:56900,Genbank:NM_001322248.1,HGNC:HGNC:30187 transmembrane protein 167B GO:0000139,GO:0009306,GO:0012505,GO:0016021,GO:0046907 Golgi membrane|protein secretion|endomembrane system|integral component of membrane|intracellular transport TMEM168 328.169271906471 374.281953574748 282.056590238194 0.753593881682743 -0.408140842916757 0.0396113584386579 0.756156754175857 1.34857 1.18127 0.980069 0.955375 GeneID:64418,Genbank:NM_022484.5,HGNC:HGNC:25826 transmembrane protein 168 GO:0016021,GO:0030133 integral component of membrane|transport vesicle TMEM169 52.8190503369124 55.7230439982297 49.9150566755951 0.895770458576901 -0.158799006241601 0.696246470755841 1 0.521588 0.603602 0.466826 0.415227 GeneID:92691,Genbank:NM_001142310.1,HGNC:HGNC:25130 transmembrane protein 169 GO:0016021 integral component of membrane TMEM17 38.3967810373239 36.5720417023156 40.2215203723322 1.09978875939501 0.137226446441591 0.779729082920769 1 0.25201 0.216349 0.241051 0.276157 GeneID:200728,Genbank:XM_011532694.2,HGNC:HGNC:26623,MIM:614950 transmembrane protein 17 GO:0007224,GO:0016021,GO:0035869,GO:0036038,GO:0060170,GO:0060271,GO:1905515 smoothened signaling pathway|integral component of membrane|ciliary transition zone|MKS complex|ciliary membrane|cilium assembly|non-motile cilium assembly TMEM170A 261.313047420798 315.695933404783 206.930161436814 0.655473002788066 -0.609391734037377 0.00370831110929236 0.233428946488645 2.64068 2.40327 1.55862 1.60689 GeneID:124491,Genbank:XM_017022941.1,HGNC:HGNC:29577 transmembrane protein 170A GO:0005635,GO:0005789,GO:0006998,GO:0016021,GO:0051292,GO:0071786 nuclear envelope|endoplasmic reticulum membrane|nuclear envelope organization|integral component of membrane|nuclear pore complex assembly|endoplasmic reticulum tubular network organization TMEM170B 240.410293521583 268.544234613253 212.276352429914 0.790470712341399 -0.339216084476483 0.118380931555707 1 1.61305 1.53551 1.35585 1.17265 GeneID:100113407,Genbank:NM_001100829.2,HGNC:HGNC:34244 transmembrane protein 170B GO:0016021 integral component of membrane TMEM171 30.4215395430987 40.0025415160171 20.8405375701804 0.520980337257716 -0.940699171282033 0.0686817210534282 0.918202374283561 1.32017 1.2905 0.877069 0.629013 GeneID:134285,Genbank:NM_173490.7,HGNC:HGNC:27031 transmembrane protein 171 GO:0016021 integral component of membrane TMEM173 537.441658956107 530.19026898038 544.693048931834 1.02735391575433 0.0389332649529999 0.840996007278059 1 7.08425 7.71774 7.27792 8.51944 GeneID:340061,Genbank:NM_198282.3,HGNC:HGNC:27962,MIM:612374 transmembrane protein 173 GO:0002218,GO:0002230,GO:0005741,GO:0005777,GO:0005789,GO:0005794,GO:0005886,GO:0006915,GO:0008134,GO:0016021,GO:0016032,GO:0019901,GO:0030659,GO:0030667,GO:0031625,GO:0032092,GO:0032479,GO:0032481,GO:0032608,GO:0033160,GO:0035438,GO:0035458,GO:0042802,GO:0042803,GO:0042993,GO:0043312,GO:0045087,GO:0045944,GO:0048471,GO:0051607,GO:0061507,GO:0071360,GO:0071407 activation of innate immune response|positive regulation of defense response to virus by host|mitochondrial outer membrane|peroxisome|endoplasmic reticulum membrane|Golgi apparatus|plasma membrane|apoptotic process|transcription factor binding|integral component of membrane|viral process|protein kinase binding|cytoplasmic vesicle membrane|secretory granule membrane|ubiquitin protein ligase binding|positive regulation of protein binding|regulation of type I interferon production|positive regulation of type I interferon production|interferon-beta production|positive regulation of protein import into nucleus, translocation|cyclic-di-GMP binding|cellular response to interferon-beta|identical protein binding|protein homodimerization activity|positive regulation of transcription factor import into nucleus|neutrophil degranulation|innate immune response|positive regulation of transcription from RNA polymerase II promoter|perinuclear region of cytoplasm|defense response to virus|cyclic-GMP-AMP binding|cellular response to exogenous dsRNA|cellular response to organic cyclic compound hsa04621,hsa04622,hsa04623,hsa05163,hsa05170 NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|Cytosolic DNA-sensing pathway|Human cytomegalovirus infection|Human immunodeficiency virus 1 infection TMEM175 352.301863694249 302.849232750268 401.75449463823 1.32658250770449 0.407714407759853 0.0344586080341147 0.730000079237491 2.83122 2.70891 3.59517 3.29963 GeneID:84286,Genbank:NM_001297427.1,HGNC:HGNC:28709,MIM:616660 transmembrane protein 175 GO:0005267,GO:0005764,GO:0005765,GO:0005768,GO:0010008,GO:0016021,GO:0022841,GO:0035751,GO:0071805,GO:0090385 potassium channel activity|lysosome|lysosomal membrane|endosome|endosome membrane|integral component of membrane|potassium ion leak channel activity|regulation of lysosomal lumen pH|potassium ion transmembrane transport|phagosome-lysosome fusion TMEM176B 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.056248 GeneID:28959,Genbank:NM_014020.3,HGNC:HGNC:29596,MIM:610385 transmembrane protein 176B GO:0009887,GO:0016021,GO:0030154,GO:0031965,GO:2001199 animal organ morphogenesis|integral component of membrane|cell differentiation|nuclear membrane|negative regulation of dendritic cell differentiation TMEM177 254.736680836838 248.288627999585 261.184733674092 1.05193997718868 0.0730523880116847 0.735277480882674 1 7.3126 7.06067 6.92513 8.20197 GeneID:80775,Genbank:NM_001105198.1,HGNC:HGNC:28143 transmembrane protein 177 GO:0031305 integral component of mitochondrial inner membrane TMEM178A 50.1169241773288 47.8917102220198 52.3421381326377 1.09292689465434 0.128196903071171 0.792270673654463 1 0.149792 0.217245 0.223513 0.199261 GeneID:130733,Genbank:XM_024452703.1,HGNC:HGNC:28517 transmembrane protein 178A GO:0005789,GO:0016021,GO:0045671,GO:0051480 endoplasmic reticulum membrane|integral component of membrane|negative regulation of osteoclast differentiation|regulation of cytosolic calcium ion concentration TMEM178B 1.72545033768766 1.02816907859967 2.42273159677566 2.35635524078913 1.23655705423232 0.731221338003923 1 0.00310134 0.00289239 0.00591391 0 GeneID:100507421,Genbank:XM_011515705.2,HGNC:HGNC:44112 transmembrane protein 178B GO:0016021 integral component of membrane TMEM179 1.80542938479706 2.64246210852658 0.968396661067546 0.366475136178024 -1.44821277409849 0.669336513612722 1 0.0195853 0.00427544 0 0.00426928 GeneID:388021,Genbank:NM_001286389.1,HGNC:HGNC:20137 transmembrane protein 179 GO:0016021 integral component of membrane TMEM179B 787.889603924348 783.927517331289 791.851690517407 1.01010829829408 0.0145099791511536 0.94947169035581 1 35.1553 38.823 37.3022 39.6441 GeneID:374395,Genbank:XM_005273982.3,HGNC:HGNC:33744 transmembrane protein 179B GO:0005730,GO:0005886,GO:0016021,GO:0016607,GO:0030667,GO:0035577,GO:0043312,GO:0101003 nucleolus|plasma membrane|integral component of membrane|nuclear speck|secretory granule membrane|azurophil granule membrane|neutrophil degranulation|ficolin-1-rich granule membrane TMEM18 490.866157144179 522.329509238846 459.402805049511 0.879526806208913 -0.185200546075496 0.292830404134673 1 2.6545 2.63593 2.38368 2.48116 GeneID:129787,Genbank:NM_152834.3,HGNC:HGNC:25257,MIM:613220 transmembrane protein 18 GO:0003677,GO:0005737,GO:0006351,GO:0016021,GO:0016477,GO:0031965 DNA binding|cytoplasm|transcription, DNA-templated|integral component of membrane|cell migration|nuclear membrane TMEM181 1262.93788351568 1345.67141013312 1180.20435689825 0.877037550185824 -0.189289482197807 0.292766824861663 1 5.99134 5.59055 5.86 4.32617 GeneID:57583,Genbank:XM_011535999.1,HGNC:HGNC:20958,MIM:613209 transmembrane protein 181 GO:0009405,GO:0015643,GO:0016021 pathogenesis|toxic substance binding|integral component of membrane TMEM182 60.2943499294308 60.5080881582176 60.0806117006441 0.992935217909122 -0.0102284998426907 1 1 0.578299 0.357488 0.427695 0.625704 GeneID:130827,Genbank:NM_001321343.1,HGNC:HGNC:26391 transmembrane protein 182 GO:0016021 integral component of membrane TMEM183A 1657.43279624396 1679.28252234968 1635.58307013825 0.973977307790784 -0.038039934816986 0.765125651008571 1 19.7792 23.042 20.9795 20.5646 GeneID:92703,Genbank:NM_138391.5,HGNC:HGNC:20173 transmembrane protein 183A GO:0016021 integral component of membrane TMEM183B 77.3725899253535 90.2867738180309 64.4584060326762 0.713929663303613 -0.486146148646377 0.144587380390578 1 2.30996 2.36654 1.82718 1.57519 GeneID:653659,Genbank:NM_001079809.1,HGNC:HGNC:33205,MIM:611365 transmembrane protein 183B GO:0016021 integral component of membrane TMEM184A 85.1378303203862 98.0700813195558 72.2055793212166 0.736265111129446 -0.441702755719757 0.168717448490862 1 0.410474 0.360781 0.26086 0.312333 GeneID:202915,Genbank:NM_001097620.1,HGNC:HGNC:28797 transmembrane protein 184A GO:0005215,GO:0005768,GO:0005886,GO:0008201,GO:0016021,GO:0030658,GO:0030659,GO:0030667,GO:0031901,GO:0048471 transporter activity|endosome|plasma membrane|heparin binding|integral component of membrane|transport vesicle membrane|cytoplasmic vesicle membrane|secretory granule membrane|early endosome membrane|perinuclear region of cytoplasm TMEM184B 1815.57895305153 1622.81743291925 2008.34047318382 1.23756402442083 0.307503163838791 0.0303519998400238 0.688551883056403 15.6471 14.7707 20.3295 18.3192 GeneID:25829,Genbank:NM_012264.4,HGNC:HGNC:1310 transmembrane protein 184B GO:0005215,GO:0016021 transporter activity|integral component of membrane TMEM184C 481.061283660278 463.877759237828 498.244808082728 1.07408643367892 0.10311009427537 0.56637168274854 1 6.33361 6.76631 8.05195 6.14778 GeneID:55751,Genbank:NM_018241.2,HGNC:HGNC:25587,MIM:613937 transmembrane protein 184C GO:0005215,GO:0016021 transporter activity|integral component of membrane TMEM185A 520.239871239929 525.337581235491 515.142161244366 0.980592631566264 -0.0282741740171298 0.863510730763028 1 6.81796 7.10322 6.99141 6.91259 GeneID:84548,Genbank:NM_001174092.2,HGNC:HGNC:17125,MIM:300031 transmembrane protein 185A GO:0016021,GO:0030425 integral component of membrane|dendrite TMEM185B 474.797341791615 462.513406236434 487.081277346796 1.05311818161181 0.0746673456305872 0.686455568669972 1 3.48809 3.73085 4.21378 3.51357 GeneID:79134,Genbank:NM_024121.2,HGNC:HGNC:18896 transmembrane protein 185B GO:0016021 integral component of membrane TMEM186 143.802007949726 152.409155006175 135.194860893277 0.887052099250855 -0.17290925403237 0.523157948925895 1 4.97146 4.22296 3.70373 4.6818 GeneID:25880,Genbank:NM_015421.3,HGNC:HGNC:24530 transmembrane protein 186 GO:0005739,GO:0016021 mitochondrion|integral component of membrane TMEM187 229.484270727052 187.598243397736 271.370298056369 1.44655031487168 0.532616504915231 0.0253541353331631 0.632510640959408 3.96603 5.0946 6.18357 7.21868 GeneID:8269,Genbank:NM_003492.2,HGNC:HGNC:13705,MIM:300059 transmembrane protein 187 GO:0016021,GO:0030133 integral component of membrane|transport vesicle TMEM189 875.364175950449 803.740061816829 946.988290084069 1.1782270600565 0.236617592522447 0.12514561637438 1 23.1612 20.8677 28.2527 24.9062 GeneID:387521,Genbank:NM_001162505.1,HGNC:HGNC:16735,MIM:610994 transmembrane protein 189 GO:0005737,GO:0005783,GO:0005789,GO:0016021,GO:0031625,GO:0061630 cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|ubiquitin protein ligase binding|ubiquitin protein ligase activity TMEM19 983.49771762935 1039.88276597196 927.112669286743 0.891554990259107 -0.16560431024244 0.286698037338591 1 11.024 10.7575 10.3182 9.4975 GeneID:55266,Genbank:NM_018279.3,HGNC:HGNC:25605 transmembrane protein 19 GO:0016020,GO:0016021 membrane|integral component of membrane TMEM190 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0 0 0 0 GeneID:147744,Genbank:XM_017026331.1,HGNC:HGNC:29632 transmembrane protein 190 GO:0002079,GO:0002244,GO:0005634,GO:0016021,GO:0043621 inner acrosomal membrane|hematopoietic progenitor cell differentiation|nucleus|integral component of membrane|protein self-association TMEM191B 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0 0 GeneID:728229,Genbank:XM_024452265.1,HGNC:HGNC:33600 transmembrane protein 191B GO:0016021 integral component of membrane TMEM191C 3.79612205304069 3.71865746181119 3.87358664427018 1.04166266563943 0.0588881476712533 1 1 0 0 0 0.16992 GeneID:645426,Genbank:NM_001207052.1,HGNC:HGNC:33601 transmembrane protein 191C GO:0016021 integral component of membrane TMEM192 638.01487928563 607.677351417727 668.352407153533 1.0998474858315 0.137303481304878 0.409975802867794 1 4.69955 5.20849 6.17166 4.88051 GeneID:201931,Genbank:XM_011531717.3,HGNC:HGNC:26775 transmembrane protein 192 GO:0005654,GO:0005764,GO:0005765,GO:0005768,GO:0005770,GO:0016021,GO:0042803,GO:0048471,GO:0070062 nucleoplasm|lysosome|lysosomal membrane|endosome|late endosome|integral component of membrane|protein homodimerization activity|perinuclear region of cytoplasm|extracellular exosome TMEM198 48.4390651282994 46.9595936927901 49.9185365638087 1.06301040188669 0.0881557141568136 0.869080324498845 1 1.00895 1.2396 1.21311 1.0609 GeneID:130612,Genbank:NM_001303098.1,HGNC:HGNC:33704 transmembrane protein 198 GO:0005886,GO:0007275,GO:0016021,GO:0016055,GO:0031410,GO:0090263 plasma membrane|multicellular organism development|integral component of membrane|Wnt signaling pathway|cytoplasmic vesicle|positive regulation of canonical Wnt signaling pathway TMEM199 955.436262928345 958.6093824879 952.26314336879 0.993379744414102 -0.00958276519622218 0.965730777357319 1 13.0153 12.4781 12.6546 12.8381 GeneID:147007,Genbank:NM_152464.2,HGNC:HGNC:18085,MIM:616815 transmembrane protein 199 GO:0005764,GO:0005783,GO:0005789,GO:0006879,GO:0007042,GO:0016021,GO:0016471,GO:0030663,GO:0033116,GO:0036295,GO:0070072,GO:1905146 lysosome|endoplasmic reticulum|endoplasmic reticulum membrane|cellular iron ion homeostasis|lysosomal lumen acidification|integral component of membrane|vacuolar proton-transporting V-type ATPase complex|COPI-coated vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|cellular response to increased oxygen levels|vacuolar proton-transporting V-type ATPase complex assembly|lysosomal protein catabolic process TMEM200A 126.901265951078 127.291051992511 126.511479909645 0.993875672557784 -0.00886270366586224 1 1 0.843063 0.71646 0.943921 0.595508 GeneID:114801,Genbank:NM_001258277.1,HGNC:HGNC:21075 transmembrane protein 200A GO:0016021 integral component of membrane TMEM200B 207.156660988387 211.716586297269 202.596735679505 0.956924250587722 -0.0635233683231068 0.783774659385965 1 3.20075 3.31065 3.81605 2.7969 GeneID:399474,Genbank:NM_001003682.3,HGNC:HGNC:33785 transmembrane protein 200B GO:0016021 integral component of membrane TMEM200C 63.4689603722136 68.3012043148504 58.6367164295768 0.858501940306603 -0.220106700010506 0.559666804507298 1 0.190618 0.188164 0.154153 0.160014 GeneID:645369,Genbank:XM_011525729.3,HGNC:HGNC:37208 transmembrane protein 200C GO:0016021 integral component of membrane TMEM201 1348.54358205901 1404.09678517137 1292.99037894664 0.920869837892856 -0.118930844648084 0.407856364698698 1 8.81228 9.0538 8.63726 8.31243 GeneID:199953,Genbank:XM_017000549.1,HGNC:HGNC:33719 transmembrane protein 201 GO:0000922,GO:0005521,GO:0005635,GO:0005639,GO:0005737,GO:0006998,GO:0007097,GO:0010761,GO:0051015,GO:0051642,GO:0090435 spindle pole|lamin binding|nuclear envelope|integral component of nuclear inner membrane|cytoplasm|nuclear envelope organization|nuclear migration|fibroblast migration|actin filament binding|centrosome localization|protein localization to nuclear envelope TMEM203 1132.19605130505 1140.06803737936 1124.32406523075 0.986190322303215 -0.0200619994541964 0.887971902926563 1 42.4258 44.0214 43.0834 42.7162 GeneID:94107,Genbank:NM_053045.1,HGNC:HGNC:28217,MIM:616499 transmembrane protein 203 GO:0005783,GO:0005789,GO:0006874,GO:0007283,GO:0016021 endoplasmic reticulum|endoplasmic reticulum membrane|cellular calcium ion homeostasis|spermatogenesis|integral component of membrane TMEM204 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0.0345942 0.0292164 0 0.0296298 GeneID:79652,Genbank:NM_001256541.1,HGNC:HGNC:14158,MIM:611002 transmembrane protein 204 GO:0001945,GO:0005886,GO:0005912,GO:0016021,GO:0030947,GO:0051145 lymph vessel development|plasma membrane|adherens junction|integral component of membrane|regulation of vascular endothelial growth factor receptor signaling pathway|smooth muscle cell differentiation TMEM205 950.33417610322 974.6484855844 926.019866622039 0.950106505389783 -0.0738388486173344 0.714283591485011 1 13.3168 13.7003 11.2671 14.8103 GeneID:374882,Genbank:XM_017026769.1,HGNC:HGNC:29631,MIM:613771 transmembrane protein 205 GO:0016021,GO:0070062 integral component of membrane|extracellular exosome TMEM206 458.512543969061 485.238987170104 431.786100768018 0.88984214414876 -0.168378666732639 0.337094725850792 1 5.57744 5.90287 4.80786 5.29152 GeneID:55248,Genbank:XM_005273177.3,HGNC:HGNC:25593 transmembrane protein 206 GO:0009986,GO:0016021 cell surface|integral component of membrane TMEM208 829.56486155324 835.326162606164 823.803560500316 0.986205864700923 -0.0200392627035926 0.891489142307568 1 33.4073 33.0478 32.8616 36.6838 GeneID:29100,Genbank:NM_001318217.1,HGNC:HGNC:25015 transmembrane protein 208 GO:0005773,GO:0005789,GO:0006624,GO:0006914,GO:0016021 vacuole|endoplasmic reticulum membrane|vacuolar protein processing|autophagy|integral component of membrane TMEM209 818.645066228159 854.033085773096 783.257046683222 0.917127286672031 -0.124806117766429 0.595953624413703 1 9.35363 7.96444 9.29587 6.60217 GeneID:84928,Genbank:NM_001301163.1,HGNC:HGNC:21898 transmembrane protein 209 GO:0016021 integral component of membrane TMEM214 2351.93254116274 2201.7933110313 2502.07177129419 1.136379041011 0.184444128308226 0.187472116070869 1 26.9981 26.8992 31.3006 31.5879 GeneID:54867,Genbank:NM_017727.4,HGNC:HGNC:25983,MIM:615301 transmembrane protein 214 GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005881,GO:0006915,GO:0016021 endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|cytoplasmic microtubule|apoptotic process|integral component of membrane TMEM216 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0.0321412 0 0 0.0280551 GeneID:51259,Genbank:XM_005274039.4,HGNC:HGNC:25018,MIM:613277 transmembrane protein 216 GO:0005829,GO:0005856,GO:0005929,GO:0016021,GO:0036038,GO:0060271,GO:0097711 cytosol|cytoskeleton|cilium|integral component of membrane|MKS complex|cilium assembly|ciliary basal body-plasma membrane docking TMEM217 40.454747460619 34.8715047781267 46.0379901431113 1.32021805299291 0.400776231092103 0.406816837481647 1 0.178434 0.392222 0.336445 0.314505 GeneID:221468,Genbank:NM_001286401.1,HGNC:HGNC:21238 transmembrane protein 217 GO:0001650,GO:0005730,GO:0016021 fibrillar center|nucleolus|integral component of membrane TMEM218 287.025731916468 275.059241662753 298.992222170182 1.08701027590548 0.120365578753269 0.54615107254851 1 2.01862 2.06929 2.15898 2.41818 GeneID:219854,Genbank:NM_001258241.1,HGNC:HGNC:27344 transmembrane protein 218 GO:0005929,GO:0016021 cilium|integral component of membrane TMEM219 897.232248630517 823.834006297936 970.630490963098 1.17818696915028 0.236568501869556 0.184533457767947 1 29.5116 29.7713 32.9909 39.3782 GeneID:124446,Genbank:NM_001083613.1,HGNC:HGNC:25201 transmembrane protein 219 GO:0005886,GO:0006915,GO:0016021,GO:0042981 plasma membrane|apoptotic process|integral component of membrane|regulation of apoptotic process TMEM220 2.24334138475269 2.54640955915669 1.94027321034868 0.761964312995765 -0.392204664976756 0.964564217020165 1 0.00997392 0.00954789 0 0 GeneID:388335,Genbank:XM_017024616.1,HGNC:HGNC:33757 transmembrane protein 220 GO:0016021 integral component of membrane TMEM221 85.791241558163 74.1820611383388 97.4004219779873 1.31299158426388 0.392857669178493 0.223490136579551 1 1.48847 1.65525 1.9351 2.33445 GeneID:100130519,Genbank:XM_011527603.2,HGNC:HGNC:21943 transmembrane protein 221 GO:0016021 integral component of membrane TMEM222 1357.70924881844 1279.04538478055 1436.37311285632 1.12300402311586 0.167363096143588 0.269623984334691 1 34.2693 37.742 40.5561 42.6231 GeneID:84065,Genbank:NM_032125.2,HGNC:HGNC:25363 transmembrane protein 222 GO:0016021 integral component of membrane TMEM223 334.060292247593 323.576310456532 344.544274038653 1.06480067577425 0.090583391967106 0.698118908304203 1 18.5034 21.6464 20.6803 23.652 GeneID:79064,Genbank:NM_001080501.2,HGNC:HGNC:28464 transmembrane protein 223 GO:0005739,GO:0007399,GO:0016021 mitochondrion|nervous system development|integral component of membrane TMEM225B 26.0820405530669 21.6395769252779 30.5245041808558 1.41058692072668 0.496295567899842 0.376220739799359 1 0.109421 0.116279 0.11686 0.193625 GeneID:100289187,Genbank:XM_017011629.2,HGNC:HGNC:53075 transmembrane protein 225B GO:0010923,GO:0016021 negative regulation of phosphatase activity|integral component of membrane TMEM229B 23.2527919499371 16.940776659552 29.5648072403223 1.7451860581405 0.803380853539463 0.176488214876827 1 0.17472 0.135232 0.316501 0.238304 GeneID:161145,Genbank:NM_001348546.1,HGNC:HGNC:20130 transmembrane protein 229B GO:0016021 integral component of membrane TMEM230 1862.78883138445 1890.75592627096 1834.82173649794 0.970417022633203 -0.0433232370782528 0.767457520582925 1 25.3157 24.8604 25.4911 23.7217 GeneID:29058,Genbank:NM_001330987.1,HGNC:HGNC:15876,MIM:617019 transmembrane protein 230 GO:0005769,GO:0005770,GO:0005776,GO:0005783,GO:0005802,GO:0008021,GO:0016021,GO:0030054,GO:0048489,GO:0055037 early endosome|late endosome|autophagosome|endoplasmic reticulum|trans-Golgi network|synaptic vesicle|integral component of membrane|cell junction|synaptic vesicle transport|recycling endosome TMEM231 104.997078328416 110.648241636176 99.3459150206564 0.897853536139477 -0.155447972770451 0.616572003423092 1 1.37482 1.34677 1.34082 1.35559 GeneID:79583,Genbank:NM_001077418.2,HGNC:HGNC:37234,MIM:614949 transmembrane protein 231 GO:0001701,GO:0001944,GO:0007224,GO:0016021,GO:0032880,GO:0035869,GO:0036038,GO:0042733,GO:0043010,GO:0060170,GO:0060271,GO:0060563 in utero embryonic development|vasculature development|smoothened signaling pathway|integral component of membrane|regulation of protein localization|ciliary transition zone|MKS complex|embryonic digit morphogenesis|camera-type eye development|ciliary membrane|cilium assembly|neuroepithelial cell differentiation TMEM232 3.80166850491267 4.20872886376855 3.39460814605679 0.80656375260468 -0.310139523153632 0.953710138019983 1 0.00963432 0.00476228 0.00937928 0 GeneID:642987,Genbank:XM_011543565.3,HGNC:HGNC:37270 transmembrane protein 232 GO:0016021 integral component of membrane TMEM234 216.539811520678 235.844737851911 197.234885189444 0.836291226956651 -0.257922666311339 0.251511789122509 1 1.09203 1.00472 0.85117 0.962042 GeneID:56063,Genbank:XM_017001821.2,HGNC:HGNC:28837 transmembrane protein 234 GO:0016021 integral component of membrane TMEM236 3.23368461950431 2.10436443188427 4.36300480712434 2.07331236976746 1.05193749240702 0.593249475059897 1 0.019418 0.00620201 0.0373721 0.00580159 GeneID:653567,Genbank:XM_011519626.2,HGNC:HGNC:23473 transmembrane protein 236 GO:0016021 integral component of membrane TMEM237 539.757266691728 553.193181906198 526.321351477259 0.951424147462659 -0.071839453040294 0.699358081463767 1 3.258 3.1167 3.33303 3.08673 GeneID:65062,Genbank:NM_001044385.2,HGNC:HGNC:14432,MIM:614423 transmembrane protein 237 GO:0016020,GO:0016021,GO:0030111,GO:0035869,GO:0060271 membrane|integral component of membrane|regulation of Wnt signaling pathway|ciliary transition zone|cilium assembly TMEM238 12.0729550323469 10.5796570892143 13.5662529754796 1.28229609533471 0.358729433522676 0.726145843049027 1 0.288379 3.16918 1.57757 2.42521 GeneID:388564,Genbank:NM_001190764.1,HGNC:HGNC:40042 transmembrane protein 238 GO:0016021 integral component of membrane TMEM240 11.4793393381592 12.7800740704684 10.17860460585 0.79644331869486 -0.328356403253047 0.734267789419357 1 0.18939 0.106694 0.233819 0.10881 GeneID:339453,Genbank:NM_001114748.1,HGNC:HGNC:25186,MIM:616101 transmembrane protein 240 GO:0016021,GO:0030054,GO:0097060 integral component of membrane|cell junction|synaptic membrane TMEM241 110.797978605649 124.178135792243 97.4178214190552 0.784500595032614 -0.350153553429776 0.214167785775474 1 0.449958 0.627108 0.498449 0.432754 GeneID:85019,Genbank:XM_017026043.1,HGNC:HGNC:31723,MIM:615430 transmembrane protein 241 GO:0005338,GO:0016021,GO:1990570 nucleotide-sugar transmembrane transporter activity|integral component of membrane|GDP-mannose transmembrane transport TMEM242 537.466141035064 554.490908323546 520.441373746582 0.938593159841143 -0.0914281483707709 0.603415486162606 1 4.38258 4.47506 3.88336 4.54426 GeneID:729515,Genbank:NM_018452.5,HGNC:HGNC:17206 transmembrane protein 242 GO:0016021 integral component of membrane TMEM243 438.178596780271 458.592835020775 417.764358539767 0.910970095119 -0.134524400170309 0.45217105617961 1 7.03997 7.5563 7.26174 6.3567 GeneID:79161,Genbank:NM_001329472.1,HGNC:HGNC:21707,MIM:616993 transmembrane protein 243 GO:0016021 integral component of membrane TMEM244 4.94142987729979 4.06465003971372 5.81820971488585 1.43141713506426 0.517444154939335 0.774048992397404 1 0.0633592 0 0.18348 0 GeneID:253582,Genbank:NM_001010876.1,HGNC:HGNC:21571 transmembrane protein 244 GO:0016021 integral component of membrane TMEM245 1717.11060524139 1886.22757979204 1547.99363069074 0.820682322363987 -0.285104217150471 0.0759990467671221 0.94157495521624 11.2495 9.68178 9.44001 7.8398 GeneID:23731,Genbank:NM_032012.3,HGNC:HGNC:1363 transmembrane protein 245 GO:0016021 integral component of membrane TMEM246 199.86337505545 182.101596771727 217.625153339173 1.19507548092495 0.257101741651303 0.269997643295573 1 1.55129 1.79646 2.30956 1.66766 GeneID:84302,Genbank:NM_032342.2,HGNC:HGNC:28180 transmembrane protein 246 GO:0016021 integral component of membrane TMEM248 4197.62223281961 4168.1230434056 4227.12142223362 1.01415466343331 0.0202776870089176 0.874782103819723 1 39.1297 38.4937 42.6478 36.5589 GeneID:55069,Genbank:XM_005250482.4,HGNC:HGNC:25476 transmembrane protein 248 GO:0016021 integral component of membrane TMEM249 5.23362188091001 4.65077399104097 5.81646977077905 1.25064554458755 0.322672961746112 0.871394440080775 1 0.206118 0.0728411 0.0810403 0.0357053 GeneID:340393,Genbank:NM_001280561.1,HGNC:HGNC:44155 transmembrane protein 249 GO:0016021 integral component of membrane TMEM25 317.174268959755 282.007502185273 352.341035734237 1.2494030584433 0.321238966627708 0.112341474133725 1 2.91388 3.62301 4.3223 3.70279 GeneID:84866,Genbank:NM_001144037.1,HGNC:HGNC:25890,MIM:613934 transmembrane protein 25 GO:0005576,GO:0005886,GO:0016021 extracellular region|plasma membrane|integral component of membrane TMEM250 1498.17132142907 1584.17248675208 1412.17015610606 0.891424493175828 -0.165815493261631 0.267662386647944 1 24.7266 27.8119 23.556 23.9245 GeneID:90120,Genbank:NM_152833.2,HGNC:HGNC:31009 transmembrane protein 250 GO:0005634,GO:0005654,GO:0005737,GO:0007049,GO:0008284,GO:0016021,GO:0016032,GO:0048524 nucleus|nucleoplasm|cytoplasm|cell cycle|positive regulation of cell proliferation|integral component of membrane|viral process|positive regulation of viral process TMEM251 276.792743145113 258.954528983061 294.630957307165 1.13777101510527 0.186210233731425 0.35991291731447 1 8.86239 8.06597 9.56547 10.2128 GeneID:26175,Genbank:NM_015676.2,HGNC:HGNC:20218 transmembrane protein 251 GO:0016021 integral component of membrane TMEM253 5.99143716310843 6.169014471598 5.81385985461886 0.94242927802905 -0.0855437354609282 1 1 0.0816486 0.0754571 0.0309267 0.1012 GeneID:643382,Genbank:NM_001146683.1,HGNC:HGNC:32545 transmembrane protein 253 GO:0016021 integral component of membrane TMEM254 127.035904158464 126.128612744964 127.943195571964 1.01438676591702 0.0206078287539629 0.957427075412267 1 1.23794 1.37634 1.27488 1.29321 GeneID:80195,Genbank:NM_001270371.1,HGNC:HGNC:25804 transmembrane protein 254 GO:0016021 integral component of membrane TMEM255A 224.079223727671 226.15897967235 221.999467782992 0.981608017973092 -0.0267810616131384 0.928691956589438 1 2.02144 2.01341 2.55929 1.62887 GeneID:55026,Genbank:XM_017029619.2,HGNC:HGNC:26086 transmembrane protein 255A GO:0016021 integral component of membrane TMEM255B 59.1066898381516 57.1452319294168 61.0681477468864 1.06864817387241 0.0957869593688595 0.836336038797251 1 0.19949 0.166875 0.285406 0.184826 GeneID:348013,Genbank:XM_017020558.1,HGNC:HGNC:28297 transmembrane protein 255B GO:0016021 integral component of membrane TMEM256 517.852127451822 525.933513841927 509.770741061718 0.969268410635899 -0.0450318615775497 0.824052685539975 1 72.681 74.509 64.1965 80.4621 GeneID:254863,Genbank:NM_152766.4,HGNC:HGNC:28618,MIM:617779 transmembrane protein 256 GO:0016021,GO:0070062 integral component of membrane|extracellular exosome TMEM258 787.35910732063 826.062832243659 748.655382397601 0.906293508405634 -0.141949743791779 0.502446343369642 1 145.823 141.523 117.828 146.234 GeneID:746,Genbank:NM_014206.3,HGNC:HGNC:1164,MIM:617615 transmembrane protein 258 GO:0005783,GO:0006487,GO:0016021,GO:0034998 endoplasmic reticulum|protein N-linked glycosylation|integral component of membrane|oligosaccharyltransferase I complex TMEM259 4276.24173569132 4171.47136732846 4381.01210405418 1.05023185304995 0.0707078577206167 0.612470100537953 1 61.5627 60.8511 65.6012 65.8935 GeneID:91304,Genbank:XM_024451773.1,HGNC:HGNC:17039,MIM:611011 transmembrane protein 259 GO:0005789,GO:0016021,GO:0034976,GO:1901215,GO:1904294 endoplasmic reticulum membrane|integral component of membrane|response to endoplasmic reticulum stress|negative regulation of neuron death|positive regulation of ERAD pathway TMEM260 238.455970718872 222.920584957388 253.991356480357 1.13938045034696 0.188249557565322 0.53081202162088 1 1.37722 1.4866 2.03373 1.27755 GeneID:54916,Genbank:XM_017021379.2,HGNC:HGNC:20185,MIM:617449 transmembrane protein 260 GO:0016021 integral component of membrane TMEM262 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0 0 0 GeneID:100130348,Genbank:NM_001242631.2,HGNC:HGNC:49389 transmembrane protein 262 GO:0016021 integral component of membrane TMEM263 563.496823052858 594.838425416611 532.155220689106 0.894621460132468 -0.160650728837108 0.391169534748469 1 6.62475 5.85417 6.04709 4.97177 GeneID:90488,Genbank:NM_001319664.1,HGNC:HGNC:28281 transmembrane protein 263 GO:0016021 integral component of membrane TMEM265 66.4465878262955 58.2596449022785 74.6335307503126 1.28105021710137 0.357327030358029 0.310378803121531 1 1.31711 1.04508 1.61561 1.47226 GeneID:100862671,Genbank:NM_001256829.1,HGNC:HGNC:51241 transmembrane protein 265 GO:0009607,GO:0016021 response to biotic stimulus|integral component of membrane TMEM266 2.72753971528646 2.54640955915669 2.90866987141623 1.14226317638373 0.191895084607054 1 1 0.0321055 0.0142105 0.0149839 0.013994 GeneID:123591,Genbank:XM_005254160.3,HGNC:HGNC:26763 transmembrane protein 266 GO:0005829,GO:0005886,GO:0016021 cytosol|plasma membrane|integral component of membrane TMEM267 119.436808642431 118.201226419385 120.672390865477 1.02090641967897 0.0298506291417062 0.941030765949265 1 1.12708 1.28982 1.41936 1.34469 GeneID:64417,Genbank:NM_022483.4,HGNC:HGNC:26139 transmembrane protein 267 GO:0016021 integral component of membrane TMEM268 469.195116133946 453.749955930994 484.640276336899 1.06807784772678 0.095016802864747 0.604980644893374 1 3.1555 3.46646 3.68923 3.45741 GeneID:203197,Genbank:XM_011518351.2,HGNC:HGNC:24513 transmembrane protein 268 GO:0016021 integral component of membrane TMEM269 2.18019744548207 0 4.36039489096415 Inf Inf 0.106784816445143 1 0 0 0.0153478 0.0286853 GeneID:100129924,Genbank:NM_001354602.1,HGNC:HGNC:52381 transmembrane protein 269 GO:0016021 integral component of membrane TMEM270 18.735375500466 14.2022620016556 23.2684889992764 1.63836500105152 0.712256801756265 0.299336786673794 1 0.256977 0.27143 0.815227 0.58167 GeneID:135886,Genbank:XM_017011741.1,HGNC:HGNC:23018,MIM:612547 transmembrane protein 270 GO:0016021 integral component of membrane TMEM272 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:283521,Genbank:NM_001351006.1,HGNC:HGNC:26737 transmembrane protein 272 TMEM30A 3796.71431608738 3847.76042534954 3745.66820682522 0.9734671062544 -0.0387958642164856 0.891060623393876 1 45.5815 39.9969 49.0286 35.397 GeneID:55754,Genbank:NM_001143958.1,HGNC:HGNC:16667,MIM:611028 transmembrane protein 30A GO:0005783,GO:0005794,GO:0005886,GO:0006855,GO:0010976,GO:0015247,GO:0015917,GO:0016020,GO:0016021,GO:0016324,GO:0030658,GO:0035577,GO:0035579,GO:0036010,GO:0043312,GO:0045332,GO:0070863 endoplasmic reticulum|Golgi apparatus|plasma membrane|drug transmembrane transport|positive regulation of neuron projection development|aminophospholipid transmembrane transporter activity|aminophospholipid transport|membrane|integral component of membrane|apical plasma membrane|transport vesicle membrane|azurophil granule membrane|specific granule membrane|protein localization to endosome|neutrophil degranulation|phospholipid translocation|positive regulation of protein exit from endoplasmic reticulum TMEM31 2.26354801432997 2.10436443188427 2.42273159677566 1.15128898781392 0.203250013275037 1 1 0.149109 0.0461104 0.0466873 0.0873164 GeneID:203562,Genbank:NM_182541.2,HGNC:HGNC:28601 transmembrane protein 31 GO:0016021 integral component of membrane TMEM33 1291.75942280729 1305.93842595585 1277.58041965874 0.978285341993556 -0.0316727693444008 0.843709714917817 1 8.68199 8.79148 9.66564 7.75813 GeneID:55161,Genbank:NM_018126.2,HGNC:HGNC:25541 transmembrane protein 33 GO:0005635,GO:0005643,GO:0005783,GO:0005789,GO:0017056,GO:0030176,GO:0034613,GO:0034976,GO:0042470,GO:0051292,GO:0070062,GO:1903371,GO:1903896,GO:1903899 nuclear envelope|nuclear pore|endoplasmic reticulum|endoplasmic reticulum membrane|structural constituent of nuclear pore|integral component of endoplasmic reticulum membrane|cellular protein localization|response to endoplasmic reticulum stress|melanosome|nuclear pore complex assembly|extracellular exosome|regulation of endoplasmic reticulum tubular network organization|positive regulation of IRE1-mediated unfolded protein response|positive regulation of PERK-mediated unfolded protein response TMEM35B 201.984315546848 213.023104368871 190.945526724826 0.896360642619237 -0.157848790466314 0.505536250108856 1 12.1835 11.0206 11.3059 10.7772 GeneID:100506144,Genbank:NM_001195156.1,HGNC:HGNC:40021 transmembrane protein 35B GO:0016021 integral component of membrane TMEM37 11.9382195732704 12.7320477957835 11.1443913507573 0.875302349591248 -0.192146651758658 0.855223196306211 1 0.245885 0.264249 0.161387 0.280239 GeneID:140738,Genbank:XM_011510659.2,HGNC:HGNC:18216 transmembrane protein 37 GO:0005244,GO:0005262,GO:0016021,GO:0034765 voltage-gated ion channel activity|calcium channel activity|integral component of membrane|regulation of ion transmembrane transport TMEM38A 166.495198438613 162.912376856236 170.07802002099 1.04398464562995 0.0621004936736756 0.865541729211947 1 3.26864 3.97546 3.41954 3.85103 GeneID:79041,Genbank:NM_024074.2,HGNC:HGNC:28462,MIM:611235 transmembrane protein 38A GO:0005267,GO:0015269,GO:0016021,GO:0031965,GO:0033017,GO:0070062 potassium channel activity|calcium-activated potassium channel activity|integral component of membrane|nuclear membrane|sarcoplasmic reticulum membrane|extracellular exosome TMEM38B 479.982472447659 489.859318194967 470.105626700351 0.959674766283096 -0.059382535480305 0.80870334431123 1 3.86011 2.9403 3.19562 3.14699 GeneID:55151,Genbank:NM_018112.2,HGNC:HGNC:25535,MIM:611236 transmembrane protein 38B GO:0005267,GO:0005634,GO:0015269,GO:0016021,GO:0031965,GO:0033017 potassium channel activity|nucleus|calcium-activated potassium channel activity|integral component of membrane|nuclear membrane|sarcoplasmic reticulum membrane TMEM39A 543.394997697208 529.958929261209 556.831066133207 1.05070607435459 0.0713591446788714 0.67372220165991 1 3.87331 3.92814 4.21962 4.00557 GeneID:55254,Genbank:NM_018266.2,HGNC:HGNC:25600 transmembrane protein 39A GO:0016021 integral component of membrane TMEM39B 410.21255905716 425.480719097485 394.944399016835 0.928231013275003 -0.107444194458996 0.596672171853581 1 2.51616 3.18017 2.46661 2.86895 GeneID:55116,Genbank:NM_001319677.1,HGNC:HGNC:25510 transmembrane protein 39B GO:0016021 integral component of membrane TMEM40 54.1598588026297 62.2860773224152 46.0336402828443 0.739067898666304 -0.43622118306082 0.259944198057442 1 0.621195 0.639477 0.4314 0.43131 GeneID:55287,Genbank:NM_001284406.1,HGNC:HGNC:25620 transmembrane protein 40 GO:0016021 integral component of membrane TMEM41A 837.822047744485 855.668013114094 819.976082374876 0.958287641711273 -0.0614693314273344 0.699056736155872 1 14.5437 14.5062 14.3411 14.1242 GeneID:90407,Genbank:XM_017007437.1,HGNC:HGNC:30544 transmembrane protein 41A GO:0016021 integral component of membrane TMEM41B 545.844021791195 550.34001438957 541.348029192821 0.983661036883311 -0.0237668368984787 0.893905604431781 1 7.01521 7.59556 7.68374 6.74323 GeneID:440026,Genbank:NM_015012.3,HGNC:HGNC:28948 transmembrane protein 41B GO:0007399,GO:0016021 nervous system development|integral component of membrane TMEM42 275.616543441043 246.424394941125 304.808691940961 1.23692580036074 0.306758959762727 0.133830516392896 1 12.4104 11.418 14.5152 17.2356 GeneID:131616,Genbank:NM_144638.2,HGNC:HGNC:28444 transmembrane protein 42 GO:0016021 integral component of membrane TMEM43 3221.53565683905 3124.31193156459 3318.75938211352 1.06223688761178 0.0871055349487144 0.528931100983588 1 31.2106 32.6671 35.86 33.5022 GeneID:79188,Genbank:NM_024334.2,HGNC:HGNC:28472,MIM:612048 transmembrane protein 43 GO:0005637,GO:0005783,GO:0005794,GO:0016021,GO:0071763 nuclear inner membrane|endoplasmic reticulum|Golgi apparatus|integral component of membrane|nuclear membrane organization TMEM44 859.267642763283 802.107168477541 916.428117049024 1.14252577842992 0.192226716699932 0.220353143967764 1 8.7594 9.31123 10.5519 11.1723 GeneID:93109,Genbank:NM_001166306.1,HGNC:HGNC:25120 transmembrane protein 44 GO:0016020 membrane TMEM45A 894.604535153478 982.775751662118 806.433318644838 0.820566967877421 -0.285307015527264 0.0700173216179646 0.92021045003939 16.6682 15.6723 14.0701 13.2064 GeneID:55076,Genbank:NM_018004.2,HGNC:HGNC:25480,MIM:616928 transmembrane protein 45A GO:0016021 integral component of membrane TMEM45B 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0202155 GeneID:120224,Genbank:NM_001331212.1,HGNC:HGNC:25194 transmembrane protein 45B GO:0016021 integral component of membrane TMEM47 299.693536704349 298.879618259069 300.507455149628 1.00544646336221 0.00783626503648407 0.957103131575651 1 4.37506 3.58919 4.73892 3.4188 GeneID:83604,Genbank:NM_031442.3,HGNC:HGNC:18515,MIM:300698 transmembrane protein 47 GO:0005886,GO:0005911,GO:0005912,GO:0016021 plasma membrane|cell-cell junction|adherens junction|integral component of membrane TMEM50A 2092.70082712626 2197.92955774458 1987.47209650793 0.904247403882858 -0.145210544014279 0.299778222159364 1 27.3379 27.3922 26.3949 24.0233 GeneID:23585,Genbank:NM_014313.3,HGNC:HGNC:30590,MIM:605348 transmembrane protein 50A TMEM50B 366.566958608151 371.582673537283 361.551243679019 0.973003504811542 -0.0394830932056163 0.835797076802057 1 5.13662 5.5973 5.70462 4.66221 GeneID:757,Genbank:XM_011529746.2,HGNC:HGNC:1280,MIM:617894 transmembrane protein 50B GO:0000139,GO:0005783,GO:0005789,GO:0005886,GO:0016021 Golgi membrane|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|integral component of membrane TMEM51 350.07573261985 369.142125182604 331.009340057096 0.896698906670039 -0.157304456203031 0.404863657579745 1 5.10272 5.09563 5.0473 4.45825 GeneID:55092,Genbank:XM_017001590.1,HGNC:HGNC:25488 transmembrane protein 51 GO:0016021 integral component of membrane TMEM52B 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0129658 0 0 0 GeneID:120939,Genbank:NM_001079815.1,HGNC:HGNC:26438 transmembrane protein 52B GO:0016021,GO:0070062 integral component of membrane|extracellular exosome TMEM53 167.809385642237 173.770382938452 161.848388346023 0.931392252288173 -0.102539213622315 0.679346348277401 1 2.27493 2.27375 2.03459 2.47055 GeneID:79639,Genbank:NM_001300746.1,HGNC:HGNC:26186 transmembrane protein 53 GO:0005634,GO:0016021 nucleus|integral component of membrane TMEM54 655.993562593509 624.801441521765 687.185683665253 1.09984650802268 0.137302198690172 0.421983048214894 1 24.7385 27.2328 28.342 31.4443 GeneID:113452,Genbank:NM_001329725.1,HGNC:HGNC:24143 transmembrane protein 54 GO:0016021 integral component of membrane TMEM56 231.333163917139 258.598727750051 204.067600084228 0.789128399276078 -0.341668034283951 0.26399951814065 1 2.32757 2.12633 2.27316 1.46308 GeneID:148534,Genbank:NM_001199679.1,HGNC:HGNC:26477 transmembrane protein 56 GO:0016021 integral component of membrane TMEM56-RWDD3 1.53387899679081 1.61429302992691 1.45346496365472 0.900372445838115 -0.151406188318497 1 1 0.376154 0.253619 0.420695 0.220438 GeneID:100527978,Genbank:NM_001199691.1,HGNC:HGNC:49388 TMEM56-RWDD3 readthrough GO:0005634,GO:0005737,GO:0032088,GO:0033235,GO:1902073 nucleus|cytoplasm|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein sumoylation|positive regulation of hypoxia-inducible factor-1alpha signaling pathway TMEM59 3253.04753665569 3186.51953964614 3319.57553366524 1.04175590087041 0.0590172719937842 0.66270113046985 1 13.6185 13.6795 13.9481 14.2637 GeneID:9528,Genbank:NM_001305052.1,HGNC:HGNC:1239,MIM:617084 transmembrane protein 59 GO:0000137,GO:0000138,GO:0000139,GO:0004175,GO:0005764,GO:0005765,GO:0005770,GO:0005797,GO:0005886,GO:0006914,GO:0010508,GO:0010955,GO:0016021,GO:0031902,GO:0070062,GO:0090285,GO:1903077 Golgi cis cisterna|Golgi trans cisterna|Golgi membrane|endopeptidase activity|lysosome|lysosomal membrane|late endosome|Golgi medial cisterna|plasma membrane|autophagy|positive regulation of autophagy|negative regulation of protein processing|integral component of membrane|late endosome membrane|extracellular exosome|negative regulation of protein glycosylation in Golgi|negative regulation of protein localization to plasma membrane TMEM59L 65.9847950764525 63.1603589218521 68.809231231053 1.08943698873197 0.123582755726161 0.743182422714532 1 2.15168 1.87125 2.05388 2.37364 GeneID:25789,Genbank:NM_012109.2,HGNC:HGNC:13237,MIM:617096 transmembrane protein 59 like GO:0000139,GO:0016020,GO:0016021 Golgi membrane|membrane|integral component of membrane TMEM60 398.341207718353 392.500839341432 404.181576095273 1.02975977522351 0.0423078213744617 0.799375701786536 1 28.4994 24.2596 29.1853 27.0524 GeneID:85025,Genbank:NM_032936.3,HGNC:HGNC:21754 transmembrane protein 60 GO:0016021 integral component of membrane TMEM61 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0274722 0 0 0 GeneID:199964,Genbank:XM_005270586.4,HGNC:HGNC:27296 transmembrane protein 61 GO:0016021 integral component of membrane TMEM62 978.924396165136 929.409046126015 1028.43974620426 1.10655233074288 0.14607168025597 0.355504044327237 1 7.97444 9.40722 10.4759 8.81756 GeneID:80021,Genbank:NM_001347004.1,HGNC:HGNC:26269 transmembrane protein 62 GO:0016021,GO:0016787 integral component of membrane|hydrolase activity TMEM63A 729.621657902954 661.988016139877 797.255299666031 1.2043349429721 0.268236682266453 0.0981687060286311 1 4.72992 4.71147 6.43821 5.47744 GeneID:9725,Genbank:NM_014698.2,HGNC:HGNC:29118 transmembrane protein 63A GO:0003676,GO:0005765,GO:0005815,GO:0005886,GO:0006811,GO:0016021,GO:0035579,GO:0043231,GO:0043312,GO:0070062,GO:0070821 nucleic acid binding|lysosomal membrane|microtubule organizing center|plasma membrane|ion transport|integral component of membrane|specific granule membrane|intracellular membrane-bounded organelle|neutrophil degranulation|extracellular exosome|tertiary granule membrane TMEM63B 1454.24590118032 1399.41760221586 1509.07420014477 1.07835873848898 0.1088372004861 0.469999530136818 1 11.5396 12.155 12.5486 13.0584 GeneID:55362,Genbank:XM_005249211.3,HGNC:HGNC:17735 transmembrane protein 63B GO:0005886,GO:0006811,GO:0015629,GO:0016021 plasma membrane|ion transport|actin cytoskeleton|integral component of membrane TMEM63C 30.2505840054163 30.4608621605105 30.040305850322 0.986193551975899 -0.0200572747828729 0.98169479664163 1 0.117789 0.226439 0.144055 0.205142 GeneID:57156,Genbank:NM_020431.3,HGNC:HGNC:23787 transmembrane protein 63C GO:0005227,GO:0006812,GO:0016021 calcium activated cation channel activity|cation transport|integral component of membrane TMEM64 547.211153381078 752.773653014119 341.648653748038 0.453853096983497 -1.13970269285449 4.99244396620679e-11 1.24489380120586e-07 9.89707 9.68388 4.2806 4.49179 GeneID:169200,Genbank:NM_001146273.1,HGNC:HGNC:25441 transmembrane protein 64 GO:0005783,GO:0016021,GO:0043462,GO:0044339,GO:0045600,GO:0045668,GO:0045672,GO:0045780,GO:0051480,GO:0090090 endoplasmic reticulum|integral component of membrane|regulation of ATPase activity|canonical Wnt signaling pathway involved in osteoblast differentiation|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of osteoclast differentiation|positive regulation of bone resorption|regulation of cytosolic calcium ion concentration|negative regulation of canonical Wnt signaling pathway TMEM65 740.370003435438 808.03503457486 672.704972296017 0.832519561048432 -0.264443924449978 0.104872459021588 1 8.43462 7.96707 7.44713 6.10428 GeneID:157378,Genbank:XM_011516847.2,HGNC:HGNC:25203,MIM:616609 transmembrane protein 65 GO:0003231,GO:0005743,GO:0005886,GO:0014704,GO:0016021,GO:1903779 cardiac ventricle development|mitochondrial inner membrane|plasma membrane|intercalated disc|integral component of membrane|regulation of cardiac conduction TMEM67 102.024077520783 106.151355124298 97.8967999172686 0.922237872541863 -0.116789182329427 0.704182876196844 1 0.756834 0.868744 0.808675 0.742465 GeneID:91147,Genbank:NM_153704.5,HGNC:HGNC:28396,MIM:609884 transmembrane protein 67 GO:0005789,GO:0005813,GO:0010826,GO:0016021,GO:0030433,GO:0030659,GO:0031005,GO:0035869,GO:0036038,GO:0051082,GO:0060170,GO:0060271,GO:0097711 endoplasmic reticulum membrane|centrosome|negative regulation of centrosome duplication|integral component of membrane|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle membrane|filamin binding|ciliary transition zone|MKS complex|unfolded protein binding|ciliary membrane|cilium assembly|ciliary basal body-plasma membrane docking TMEM68 257.311831012732 300.417476049842 214.206185975622 0.713028379015083 -0.487968596830331 0.0210223312646756 0.592770523829303 2.70033 2.44218 1.97307 1.96638 GeneID:137695,Genbank:NM_001286661.1,HGNC:HGNC:26510 transmembrane protein 68 GO:0008152,GO:0016021,GO:0016746 metabolic process|integral component of membrane|transferase activity, transferring acyl groups TMEM69 458.255047383004 457.563648941321 458.946445824686 1.00302208640604 0.00435337424286453 0.957619192378979 1 17.403 14.433 16.2889 15.5949 GeneID:51249,Genbank:NM_016486.3,HGNC:HGNC:28035 transmembrane protein 69 GO:0016021 integral component of membrane TMEM70 733.497575870258 775.893252800377 691.10189894014 0.890717758461998 -0.166959737184222 0.304708479744117 1 15.2122 15.2726 15.0853 13.1576 GeneID:54968,Genbank:NM_001040613.2,HGNC:HGNC:26050,MIM:612418 transmembrane protein 70 GO:0005654,GO:0005739,GO:0005743,GO:0032592,GO:0033615 nucleoplasm|mitochondrion|mitochondrial inner membrane|integral component of mitochondrial membrane|mitochondrial proton-transporting ATP synthase complex assembly TMEM71 72.0503478099056 68.5031180686981 75.5975775511132 1.10356403741068 0.142170348488645 0.704809784196746 1 0.919793 1.26988 1.2392 1.35809 GeneID:137835,Genbank:NM_144649.2,HGNC:HGNC:26572 transmembrane protein 71 GO:0005739,GO:0016021 mitochondrion|integral component of membrane TMEM72 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00610883 0 0 0 GeneID:643236,Genbank:XM_011540071.2,HGNC:HGNC:31658 transmembrane protein 72 GO:0016021 integral component of membrane TMEM74 35.1693219211844 45.6236496558649 24.7149941865039 0.541714535617535 -0.884395292278534 0.0712482495531292 0.92622724419068 0.389058 0.266 0.177177 0.185513 GeneID:157753,Genbank:NM_153015.2,HGNC:HGNC:26409,MIM:613935 transmembrane protein 74 GO:0000421,GO:0005765,GO:0016021,GO:0016236,GO:0031410 autophagosome membrane|lysosomal membrane|integral component of membrane|macroautophagy|cytoplasmic vesicle TMEM74B 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.0110059 0 0.0102709 0 GeneID:55321,Genbank:NM_001304749.1,HGNC:HGNC:15893 transmembrane protein 74B GO:0016021 integral component of membrane TMEM79 129.137765249254 125.50427117406 132.771259324448 1.05790231744631 0.0812064207960985 0.808576002731453 1 2.01178 2.53343 2.02428 2.25542 GeneID:84283,Genbank:NM_032323.2,HGNC:HGNC:28196,MIM:615531 transmembrane protein 79 GO:0002070,GO:0005765,GO:0016021,GO:0031069,GO:0032588,GO:0042335,GO:0042802,GO:0045055,GO:0045684,GO:0061436,GO:0070268 epithelial cell maturation|lysosomal membrane|integral component of membrane|hair follicle morphogenesis|trans-Golgi network membrane|cuticle development|identical protein binding|regulated exocytosis|positive regulation of epidermis development|establishment of skin barrier|cornification TMEM80 318.665166540068 302.955093954746 334.37523912539 1.1037122193936 0.142364054565601 0.491072064870015 1 5.27416 6.06714 6.12265 6.7983 GeneID:283232,Genbank:XM_017017600.1,HGNC:HGNC:27453 transmembrane protein 80 GO:0005929,GO:0016021 cilium|integral component of membrane TMEM81 34.8214407939892 28.9328130248455 40.710068563133 1.40705532255623 0.492679053527143 0.303297114980819 1 1.02833 0.819491 1.31233 1.25167 GeneID:388730,Genbank:NM_203376.1,HGNC:HGNC:32349 transmembrane protein 81 GO:0016021 integral component of membrane TMEM86A 31.308497310668 30.1530872021849 32.4639074191511 1.07663627281251 0.1065309369396 0.843217992900359 1 0.435193 0.236619 0.270389 0.449554 GeneID:144110,Genbank:NM_153347.2,HGNC:HGNC:26890 transmembrane protein 86A GO:0016021 integral component of membrane TMEM86B 82.363951129616 74.0958172440768 90.6320850151552 1.22317410599045 0.290629770972094 0.406230228097099 1 1.43527 2.12099 2.22511 1.8714 GeneID:255043,Genbank:NM_173804.4,HGNC:HGNC:28448,MIM:617806 transmembrane protein 86B GO:0005737,GO:0005789,GO:0016020,GO:0016021,GO:0016803,GO:0036151,GO:0046485,GO:0047408,GO:0047409 cytoplasm|endoplasmic reticulum membrane|membrane|integral component of membrane|ether hydrolase activity|phosphatidylcholine acyl-chain remodeling|ether lipid metabolic process|alkenylglycerophosphocholine hydrolase activity|alkenylglycerophosphoethanolamine hydrolase activity hsa00565 Ether lipid metabolism TMEM87A 1808.27904496124 1887.33421811151 1729.22387181097 0.916225571081549 -0.126225267069933 0.385372188324453 1 11.3846 10.4909 10.9669 9.75423 GeneID:25963,Genbank:NM_001286487.1,HGNC:HGNC:24522 transmembrane protein 87A GO:0005829,GO:0016021,GO:0032580,GO:0042147 cytosol|integral component of membrane|Golgi cisterna membrane|retrograde transport, endosome to Golgi TMEM87B 426.731258867729 480.769492621841 372.693025113617 0.775201070020402 -0.367357532761739 0.0466843654214995 0.79332376136203 4.47743 3.879 3.55465 2.81653 GeneID:84910,Genbank:NM_032824.2,HGNC:HGNC:25913,MIM:617203 transmembrane protein 87B GO:0000139,GO:0005829,GO:0016021,GO:0042147 Golgi membrane|cytosol|integral component of membrane|retrograde transport, endosome to Golgi TMEM88 1.75196502471523 1.56626675524197 1.93766329418849 1.23712214902317 0.306987953903475 1 1 0.127952 0.0540352 0.0573485 0.160177 GeneID:92162,Genbank:XM_005256856.3,HGNC:HGNC:32371,MIM:617813 transmembrane protein 88 GO:0005829,GO:0005886,GO:0007275,GO:0016021,GO:0016055,GO:0030165,GO:0050821,GO:0072659,GO:0090090 cytosol|plasma membrane|multicellular organism development|integral component of membrane|Wnt signaling pathway|PDZ domain binding|protein stabilization|protein localization to plasma membrane|negative regulation of canonical Wnt signaling pathway TMEM89 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.194744 GeneID:440955,Genbank:NM_001008269.2,HGNC:HGNC:32372 transmembrane protein 89 GO:0005634,GO:0016021 nucleus|integral component of membrane TMEM8A 1245.84593123444 973.351776167907 1518.34008630097 1.55990888749254 0.641461765368645 1.86059145420223e-05 0.00764082890525714 11.4721 12.8461 20.221 18.6574 GeneID:58986,Genbank:NM_021259.2,HGNC:HGNC:17205 transmembrane protein 8A GO:0004623,GO:0005765,GO:0005886,GO:0005887,GO:0070062,GO:0102567,GO:0102568 phospholipase A2 activity|lysosomal membrane|plasma membrane|integral component of plasma membrane|extracellular exosome|phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)|phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) TMEM8B 311.292571913342 259.108416462224 363.47672736446 1.40279784164191 0.488307115960769 0.0135455650910693 0.478908985648049 0.526046 0.56575 0.7722 0.712329 GeneID:51754,Genbank:XM_017014806.1,HGNC:HGNC:21427,MIM:616888 transmembrane protein 8B GO:0005634,GO:0005739,GO:0005783,GO:0005886,GO:0007160,GO:0007346,GO:0009986,GO:0016021,GO:0040008 nucleus|mitochondrion|endoplasmic reticulum|plasma membrane|cell-matrix adhesion|regulation of mitotic cell cycle|cell surface|integral component of membrane|regulation of growth TMEM9 1194.54347025252 1114.09628707733 1274.99065342771 1.14441693075961 0.194612746484188 0.274070777039927 1 18.5578 21.4215 21.4843 23.6068 GeneID:252839,Genbank:NM_001288564.1,HGNC:HGNC:18823,MIM:616877 transmembrane protein 9 GO:0005764,GO:0005765,GO:0005770,GO:0016021,GO:0031902 lysosome|lysosomal membrane|late endosome|integral component of membrane|late endosome membrane TMEM91 21.0883654081439 20.3712764732536 21.8054543430343 1.07040196384668 0.0981526679803434 0.927781763982939 1 0.226423 0.466453 0.375017 0.233517 GeneID:641649,Genbank:NM_001098825.1,HGNC:HGNC:32393 transmembrane protein 91 GO:0002244,GO:0009607,GO:0016021 hematopoietic progenitor cell differentiation|response to biotic stimulus|integral component of membrane TMEM92 8.07766152907382 11.3098598645963 4.84546319355132 0.428428225598024 -1.22287456440497 0.250843817497026 1 0.128791 0.142677 0.0602823 0.0843595 GeneID:162461,Genbank:NM_001168215.1,HGNC:HGNC:26579 transmembrane protein 92 GO:0005634,GO:0005654,GO:0016021 nucleus|nucleoplasm|integral component of membrane TMEM94 1762.53375839192 1738.25275271712 1786.81476406672 1.02793725554221 0.0397522062820698 0.801331418489251 1 8.28969 8.7704 9.28314 8.55478 GeneID:9772,Genbank:XM_011525516.1,HGNC:HGNC:28983 transmembrane protein 94 GO:0016021 integral component of membrane TMEM95 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0612552 0 0 0 GeneID:339168,Genbank:XM_017024571.1,HGNC:HGNC:27898,MIM:617814 transmembrane protein 95 GO:0016021 integral component of membrane TMEM97 1594.76715674589 1629.06288263 1560.47143086178 0.957895147879447 -0.0620603490648479 0.671916443863504 1 26.7135 26.8968 26.2907 26.0352 GeneID:27346,Genbank:XM_005257965.3,HGNC:HGNC:28106,MIM:612912 transmembrane protein 97 GO:0001558,GO:0005764,GO:0005791,GO:0005829,GO:0005886,GO:0016021,GO:0030867,GO:0031965,GO:0042632 regulation of cell growth|lysosome|rough endoplasmic reticulum|cytosol|plasma membrane|integral component of membrane|rough endoplasmic reticulum membrane|nuclear membrane|cholesterol homeostasis TMEM98 37.71429082327 39.5604963887447 35.8680852577953 0.906664186043936 -0.141359796437094 0.788759355957013 1 1.01098 0.930398 1.09449 0.77708 GeneID:26022,Genbank:NM_001301746.1,HGNC:HGNC:24529,MIM:615949 transmembrane protein 98 GO:0005783,GO:0016021 endoplasmic reticulum|integral component of membrane TMEM99 252.385759284228 246.95268396266 257.818834605797 1.04400094167343 0.0621230131979995 0.76078175721209 1 4.72119 4.64561 4.85948 4.51126 GeneID:147184,Genbank:NM_001195387.1,HGNC:HGNC:28305 transmembrane protein 99 GO:0016021 integral component of membrane TMEM9B 1415.32052008203 1395.62047551319 1435.02056465086 1.02823123465797 0.0401647427228739 0.783061086321808 1 33.3747 34.0228 36.8917 33.4303 GeneID:56674,Genbank:NM_001286095.1,HGNC:HGNC:1168 TMEM9 domain family member B GO:0004871,GO:0005765,GO:0016021,GO:0031901,GO:0043123 signal transducer activity|lysosomal membrane|integral component of membrane|early endosome membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling TMF1 237.471180559065 236.459270767707 238.483090350422 1.00855885064749 0.0122952694343858 0.958700135468447 1 1.23936 0.991062 1.38134 0.851261 GeneID:7110,Genbank:NM_007114.2,HGNC:HGNC:11870,MIM:601126 TATA element modulatory factor 1 GO:0000139,GO:0001675,GO:0001819,GO:0003677,GO:0003712,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0006355,GO:0006366,GO:0007289,GO:0010629,GO:0030317,GO:0032275,GO:0033327,GO:0042742,GO:0043066,GO:0061136,GO:0071407,GO:2000845 Golgi membrane|acrosome assembly|positive regulation of cytokine production|DNA binding|transcription cofactor activity|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|spermatid nucleus differentiation|negative regulation of gene expression|flagellated sperm motility|luteinizing hormone secretion|Leydig cell differentiation|defense response to bacterium|negative regulation of apoptotic process|regulation of proteasomal protein catabolic process|cellular response to organic cyclic compound|positive regulation of testosterone secretion TMIE 0.972638154859436 0.490071401957362 1.45520490776151 2.96937324224464 1.5701584476161 0.837389832160054 1 0 0.0134703 0.0428851 0 GeneID:259236,Genbank:XM_006713097.4,HGNC:HGNC:30800,MIM:607237 transmembrane inner ear GO:0007605,GO:0016021,GO:0042472 sensory perception of sound|integral component of membrane|inner ear morphogenesis TMIGD3 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:57413,Genbank:NM_001302680.1,HGNC:HGNC:51375 transmembrane and immunoglobulin domain containing 3 GO:0005887,GO:0006954,GO:0007165,GO:0007190,GO:0008016,GO:0008285,GO:0009611,GO:0016020,GO:0030336,GO:0032088 integral component of plasma membrane|inflammatory response|signal transduction|activation of adenylate cyclase activity|regulation of heart contraction|negative regulation of cell proliferation|response to wounding|membrane|negative regulation of cell migration|negative regulation of NF-kappaB transcription factor activity TMLHE 286.570292225782 287.705045564275 285.43553888729 0.992111689690622 -0.0114255497869271 0.963469741071532 1 1.52769 1.69728 1.45299 1.51924 GeneID:55217,Genbank:NM_018196.3,HGNC:HGNC:18308,MIM:300777 trimethyllysine hydroxylase, epsilon GO:0005506,GO:0005739,GO:0005759,GO:0016702,GO:0045329,GO:0050353,GO:0051354 iron ion binding|mitochondrion|mitochondrial matrix|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|carnitine biosynthetic process|trimethyllysine dioxygenase activity|negative regulation of oxidoreductase activity hsa00310 Lysine degradation TMOD1 174.780840399851 198.37000558569 151.191675214013 0.762170040614848 -0.391815195089243 0.104259185590202 1 1.71821 2.21901 1.32761 1.58027 GeneID:7111,Genbank:NM_001166116.1,HGNC:HGNC:11871,MIM:190930 tropomodulin 1 GO:0003779,GO:0005523,GO:0005829,GO:0005865,GO:0005884,GO:0006936,GO:0007015,GO:0008344,GO:0016020,GO:0030016,GO:0030017,GO:0030049,GO:0030239,GO:0030863,GO:0051015,GO:0051694,GO:0070307 actin binding|tropomyosin binding|cytosol|striated muscle thin filament|actin filament|muscle contraction|actin filament organization|adult locomotory behavior|membrane|myofibril|sarcomere|muscle filament sliding|myofibril assembly|cortical cytoskeleton|actin filament binding|pointed-end actin filament capping|lens fiber cell development TMOD2 279.34529109317 279.498293244839 279.192288941501 0.998905165753305 -0.00158037722180233 0.990976749646899 1 1.33387 1.11238 1.48726 0.969244 GeneID:29767,Genbank:NM_014548.3,HGNC:HGNC:11872,MIM:602928 tropomodulin 2 GO:0003779,GO:0005523,GO:0005865,GO:0006936,GO:0007015,GO:0007270,GO:0007399,GO:0007611,GO:0030239,GO:0030426,GO:0045745,GO:0051694 actin binding|tropomyosin binding|striated muscle thin filament|muscle contraction|actin filament organization|neuron-neuron synaptic transmission|nervous system development|learning or memory|myofibril assembly|growth cone|positive regulation of G-protein coupled receptor protein signaling pathway|pointed-end actin filament capping TMOD3 1424.87705581029 1605.56684729966 1244.18726432093 0.774920873841831 -0.367879088686166 0.0638358680153434 0.898414114353023 14.7911 13.4789 12.7386 9.55578 GeneID:29766,Genbank:NM_014547.4,HGNC:HGNC:11873,MIM:605112 tropomodulin 3 GO:0003779,GO:0005523,GO:0005865,GO:0005913,GO:0006936,GO:0007015,GO:0030239,GO:0048821,GO:0051694,GO:0098641,GO:1901992 actin binding|tropomyosin binding|striated muscle thin filament|cell-cell adherens junction|muscle contraction|actin filament organization|myofibril assembly|erythrocyte development|pointed-end actin filament capping|cadherin binding involved in cell-cell adhesion|positive regulation of mitotic cell cycle phase transition TMOD4 6.35471274107126 10.771762187954 1.93766329418849 0.179883593824171 -2.47486448243826 0.0527346607638601 0.839722270863765 0.0257554 0.117272 0 0.022521 GeneID:29765,Genbank:XM_011509449.1,HGNC:HGNC:11874,MIM:605834 tropomodulin 4 GO:0005523,GO:0005865,GO:0006936,GO:0007015,GO:0030239,GO:0051015,GO:0051694 tropomyosin binding|striated muscle thin filament|muscle contraction|actin filament organization|myofibril assembly|actin filament binding|pointed-end actin filament capping TMPO 4350.25846467304 4704.46946719991 3996.04746214617 0.849415112587522 -0.235458317893693 0.08198286487732 0.959822780610495 25.677 24.7696 23.5871 19.513 GeneID:7112,Genbank:NM_001032283.2,HGNC:HGNC:11875,MIM:188380 thymopoietin GO:0003677,GO:0005521,GO:0005634,GO:0005635,GO:0005637,GO:0005737,GO:0016020,GO:0016021,GO:0031965 DNA binding|lamin binding|nucleus|nuclear envelope|nuclear inner membrane|cytoplasm|membrane|integral component of membrane|nuclear membrane TMPPE 47.0445644547648 39.8006277621694 54.2885011473602 1.36401117770714 0.447855466910902 0.276588708680884 1 0.578655 0.424446 0.834318 0.546628 GeneID:643853,Genbank:NM_001136238.1,HGNC:HGNC:33865 transmembrane protein with metallophosphoesterase domain GO:0016021,GO:0016787,GO:0046872 integral component of membrane|hydrolase activity|metal ion binding TMPRSS11E 0.726732481827358 0 1.45346496365472 Inf Inf 0.598765617812696 1 0 0 0.0188202 0.0349071 GeneID:28983,Genbank:NM_014058.3,HGNC:HGNC:24465,MIM:610399 transmembrane serine protease 11E GO:0004252,GO:0005576,GO:0005887,GO:0006508,GO:0008236,GO:0050890 serine-type endopeptidase activity|extracellular region|integral component of plasma membrane|proteolysis|serine-type peptidase activity|cognition TMPRSS2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:7113,Genbank:NM_005656.3,HGNC:HGNC:11876,MIM:602060 transmembrane serine protease 2 hsa05164,hsa05202,hsa05215 Influenza A|Transcriptional misregulation in cancer|Prostate cancer TMPRSS3 31.1329232010691 31.7291626125348 30.5366837896034 0.962416946280822 -0.0552660491106361 0.9415690917271 1 0.370941 0.380193 0.382604 0.291772 GeneID:64699,Genbank:NM_001256317.1,HGNC:HGNC:11877,MIM:605511 transmembrane serine protease 3 TMPRSS5 125.002973046541 102.68263769102 147.323308402063 1.43474409807596 0.520793439786569 0.0585918659506372 0.878658544068731 0.441111 0.604684 0.736034 0.807625 GeneID:80975,Genbank:NM_001288749.1,HGNC:HGNC:14908,MIM:606751 transmembrane serine protease 5 GO:0004252,GO:0005044,GO:0005886,GO:0006508,GO:0008233,GO:0016021,GO:0043025 serine-type endopeptidase activity|scavenger receptor activity|plasma membrane|proteolysis|peptidase activity|integral component of membrane|neuronal cell body TMPRSS9 4.6984607399795 4.06465003971372 5.33227144024528 1.3118648316943 0.39161907918599 0.860396053489489 1 0.0127141 0.0433122 0.0234155 0 GeneID:360200,Genbank:XM_011527978.2,HGNC:HGNC:30079,MIM:610477 transmembrane serine protease 9 GO:0004252,GO:0005887 serine-type endopeptidase activity|integral component of plasma membrane TMSB10 23343.4597487783 22520.4612620757 24166.458235481 1.07308895471769 0.101769674613278 0.669149243402284 1 1812.08 1953.17 1766.57 2224.09 GeneID:9168,Genbank:NM_021103.3,HGNC:HGNC:11879,MIM:188399 thymosin beta 10 GO:0003785,GO:0005737,GO:0005856,GO:0007015,GO:0030036 actin monomer binding|cytoplasm|cytoskeleton|actin filament organization|actin cytoskeleton organization TMSB15A 85.2555628771203 83.7717667685303 86.7393589857103 1.03542472997352 0.0502226808970433 0.886358632254916 1 6.72274 6.61212 5.98571 7.75244 GeneID:11013,Genbank:NM_021992.2,HGNC:HGNC:30744,MIM:300939 thymosin beta 15a GO:0003785,GO:0005737,GO:0005856,GO:0007015 actin monomer binding|cytoplasm|cytoskeleton|actin filament organization TMSB15B 13.8373083242274 14.5864721991351 13.0881444493196 0.897279634900046 -0.156370427453649 0.910512673904929 1 0.154553 0.0718815 0.132149 0.0824822 GeneID:286527,Genbank:NM_001350213.1,HGNC:HGNC:28612,MIM:301011 thymosin beta 15B GO:0001939,GO:0005634,GO:0005737,GO:0016569,GO:0035064,GO:0044726,GO:1901536,GO:2000653 female pronucleus|nucleus|cytoplasm|covalent chromatin modification|methylated histone binding|protection of DNA demethylation of female pronucleus|negative regulation of DNA demethylation|regulation of genetic imprinting TMSB4X 31380.5840073142 32504.8269209712 30256.3410936571 0.930826094451117 -0.103416439572191 0.676005669566901 1 2105.98 2670.15 2012.79 2624.61 GeneID:7114,Genbank:NM_021109.3,HGNC:HGNC:11881,MIM:300159 thymosin beta 4, X-linked GO:0001649,GO:0003785,GO:0005615,GO:0005634,GO:0005829,GO:0005856,GO:0007015,GO:0007253,GO:0014911,GO:0019899,GO:0030334,GO:0032088,GO:0033209,GO:0042989,GO:0043536,GO:0045893,GO:0050727,GO:0051152,GO:1901223,GO:1903026,GO:1905273,GO:2000483,GO:2001028,GO:2001171 osteoblast differentiation|actin monomer binding|extracellular space|nucleus|cytosol|cytoskeleton|actin filament organization|cytoplasmic sequestering of NF-kappaB|positive regulation of smooth muscle cell migration|enzyme binding|regulation of cell migration|negative regulation of NF-kappaB transcription factor activity|tumor necrosis factor-mediated signaling pathway|sequestering of actin monomers|positive regulation of blood vessel endothelial cell migration|positive regulation of transcription, DNA-templated|regulation of inflammatory response|positive regulation of smooth muscle cell differentiation|negative regulation of NIK/NF-kappaB signaling|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|positive regulation of proton-transporting ATP synthase activity, rotational mechanism|negative regulation of interleukin-8 secretion|positive regulation of endothelial cell chemotaxis|positive regulation of ATP biosynthetic process hsa04810 Regulation of actin cytoskeleton TMTC1 1157.29782285483 1175.07177832473 1139.52386738493 0.969748306788142 -0.0443177431206054 0.869564642520141 1 2.86884 2.50931 3.11807 2.13431 GeneID:83857,Genbank:NM_175861.3,HGNC:HGNC:24099,MIM:615855 transmembrane and tetratricopeptide repeat containing 1 GO:0005739,GO:0006396,GO:0016021 mitochondrion|RNA processing|integral component of membrane TMTC2 273.275757163093 245.598139616373 300.953374709812 1.22538947233031 0.293240361877445 0.155717419627135 1 0.993186 1.02324 1.26111 1.16514 GeneID:160335,Genbank:NM_152588.2,HGNC:HGNC:25440,MIM:615856 transmembrane and tetratricopeptide repeat containing 2 GO:0005783,GO:0005789,GO:0016021,GO:0055074 endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|calcium ion homeostasis TMTC3 118.475778231124 124.965156496563 111.986399965685 0.896140997260823 -0.158202353625056 0.851994256696024 1 0.903643 0.539759 0.949938 0.421222 GeneID:160418,Genbank:NM_181783.3,HGNC:HGNC:26899,MIM:617218 transmembrane and tetratricopeptide repeat containing 3 GO:0005783,GO:0016021,GO:0034976,GO:1901800 endoplasmic reticulum|integral component of membrane|response to endoplasmic reticulum stress|positive regulation of proteasomal protein catabolic process TMTC4 795.612491143467 809.486648471371 781.738333815562 0.965721096563843 -0.0503215007558226 0.758826235754321 1 4.76894 4.64886 4.64976 4.29385 GeneID:84899,Genbank:NM_001286453.2,HGNC:HGNC:25904 transmembrane and tetratricopeptide repeat containing 4 GO:0016021 integral component of membrane TMUB1 1584.91237652652 1501.21614965234 1668.60860340069 1.11150456500692 0.152513873600463 0.301578661177209 1 38.3434 39.2234 45.7512 42.7929 GeneID:83590,Genbank:NM_001136044.1,HGNC:HGNC:21709,MIM:614792 transmembrane and ubiquitin like domain containing 1 GO:0005654,GO:0005730,GO:0005815,GO:0005829,GO:0016021,GO:0030054,GO:0030433,GO:0045211,GO:0055037 nucleoplasm|nucleolus|microtubule organizing center|cytosol|integral component of membrane|cell junction|ubiquitin-dependent ERAD pathway|postsynaptic membrane|recycling endosome TMUB2 1704.34042630564 1558.3525899275 1850.32826268377 1.18736175281735 0.247759547013693 0.090226546494213 0.979717040875575 18.0657 21.1453 24.4475 23.3378 GeneID:79089,Genbank:NM_001353191.1,HGNC:HGNC:28459 transmembrane and ubiquitin like domain containing 2 GO:0016021 integral component of membrane TMX1 1338.88514466107 1447.71786359641 1230.05242572573 0.849649269830824 -0.235060666693026 0.239106933019213 1 19.1234 16.1288 16.2149 13.7673 GeneID:81542,Genbank:NM_030755.4,HGNC:HGNC:15487,MIM:610527 thioredoxin related transmembrane protein 1 GO:0003756,GO:0005789,GO:0006457,GO:0015036,GO:0016021,GO:0034976,GO:0045454 protein disulfide isomerase activity|endoplasmic reticulum membrane|protein folding|disulfide oxidoreductase activity|integral component of membrane|response to endoplasmic reticulum stress|cell redox homeostasis TMX2 5095.00068465214 4942.12772218647 5247.87364711781 1.06186524147459 0.0866006891249482 0.525067200751729 1 61.9938 68.5566 70.163 73.4701 GeneID:51075,Genbank:NM_001347895.1,HGNC:HGNC:30739,MIM:616715 thioredoxin related transmembrane protein 2 GO:0005623,GO:0016021,GO:0045454 cell|integral component of membrane|cell redox homeostasis TMX3 379.377444287005 396.228288457496 362.526600116514 0.914943760143472 -0.128245028491479 0.729574342287705 1 2.56251 1.65948 2.25018 1.89717 GeneID:54495,Genbank:NM_001350516.1,HGNC:HGNC:24718,MIM:616102 thioredoxin related transmembrane protein 3 GO:0002576,GO:0003756,GO:0005789,GO:0005886,GO:0006457,GO:0009986,GO:0016021,GO:0016972,GO:0018171,GO:0031092,GO:0034976,GO:0045454 platelet degranulation|protein disulfide isomerase activity|endoplasmic reticulum membrane|plasma membrane|protein folding|cell surface|integral component of membrane|thiol oxidase activity|peptidyl-cysteine oxidation|platelet alpha granule membrane|response to endoplasmic reticulum stress|cell redox homeostasis TMX4 903.472810705347 834.239141596917 972.706479813776 1.16598039016942 0.221543525036497 0.148170007255605 1 6.0813 5.78291 7.56426 6.34018 GeneID:56255,Genbank:NM_021156.3,HGNC:HGNC:25237,MIM:616766 thioredoxin related transmembrane protein 4 GO:0003756,GO:0005783,GO:0006457,GO:0016021,GO:0034976,GO:0045454,GO:0055114 protein disulfide isomerase activity|endoplasmic reticulum|protein folding|integral component of membrane|response to endoplasmic reticulum stress|cell redox homeostasis|oxidation-reduction process TNC 26074.9738220093 26350.8730152546 25799.0746287641 0.979059578550926 -0.0305314403038991 0.8026359821306 1 81.5285 83.7545 90.9926 74.035 GeneID:3371,Genbank:NM_002160.3,HGNC:HGNC:5318,MIM:187380 tenascin C hsa04151,hsa04510,hsa04512,hsa05165,hsa05206 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Human papillomavirus infection|MicroRNAs in cancer TNF 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:7124,Genbank:NM_000594.3,HGNC:HGNC:11892,MIM:191160 tumor necrosis factor hsa01523,hsa04010,hsa04060,hsa04064,hsa04071,hsa04150,hsa04210,hsa04217,hsa04350,hsa04380,hsa04612,hsa04620,hsa04621,hsa04622,hsa04625,hsa04640,hsa04650,hsa04657,hsa04660,hsa04664,hsa04668,hsa04920,hsa04930,hsa04931,hsa04932,hsa04933,hsa04940,hsa05010,hsa05014,hsa05133,hsa05134,hsa05140,hsa05142,hsa05143,hsa05144,hsa05145,hsa05146,hsa05152,hsa05160,hsa05161,hsa05163,hsa05164,hsa05165,hsa05166,hsa05168,hsa05169,hsa05170,hsa05205,hsa05310,hsa05321,hsa05322,hsa05323,hsa05330,hsa05332,hsa05410,hsa05414,hsa05418 Antifolate resistance|MAPK signaling pathway|Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Sphingolipid signaling pathway|mTOR signaling pathway|Apoptosis|Necroptosis|TGF-beta signaling pathway|Osteoclast differentiation|Antigen processing and presentation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|C-type lectin receptor signaling pathway|Hematopoietic cell lineage|Natural killer cell mediated cytotoxicity|IL-17 signaling pathway|T cell receptor signaling pathway|Fc epsilon RI signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Type II diabetes mellitus|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|AGE-RAGE signaling pathway in diabetic complications|Type I diabetes mellitus|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Pertussis|Legionellosis|Leishmaniasis|Chagas disease (American trypanosomiasis)|African trypanosomiasis|Malaria|Toxoplasmosis|Amoebiasis|Tuberculosis|Hepatitis C|Hepatitis B|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Proteoglycans in cancer|Asthma|Inflammatory bowel disease (IBD)|Systemic lupus erythematosus|Rheumatoid arthritis|Allograft rejection|Graft-versus-host disease|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM)|Fluid shear stress and atherosclerosis TNFAIP1 1733.70199203239 1705.77275301813 1761.63123104665 1.0327467289706 0.0464864907383349 0.74987294388209 1 16.5591 16.3511 17.9834 16.9066 GeneID:7126,Genbank:NM_021137.4,HGNC:HGNC:11894,MIM:191161 TNF alpha induced protein 1 TNFAIP2 2034.2179669861 2283.1833813758 1785.25255259639 0.781913781941001 -0.354918557973225 0.0106813099916576 0.413666579021508 19.9465 21.3078 15.7007 17.132 GeneID:7127,Genbank:XM_011537115.2,HGNC:HGNC:11895,MIM:603300 TNF alpha induced protein 2 TNFAIP3 193.788134043072 205.835729473781 181.740538612364 0.882939706711674 -0.179613170941101 0.443109098909836 1 0.873536 0.914001 0.804732 0.75869 GeneID:7128,Genbank:XM_011536095.1,HGNC:HGNC:11896,MIM:191163 TNF alpha induced protein 3 hsa04064,hsa04217,hsa04621,hsa04657,hsa04668,hsa05162,hsa05169 NF-kappa B signaling pathway|Necroptosis|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Measles|Epstein-Barr virus infection TNFAIP6 1.78185123348129 2.59443583384164 0.969266633120943 0.373594374729911 -1.42045536256559 0.670799861503385 1 0.101251 0.0648537 0.0326001 0.0302284 GeneID:7130,Genbank:NM_007115.3,HGNC:HGNC:11898,MIM:600410 TNF alpha induced protein 6 GO:0005540,GO:0005576,GO:0005615,GO:0006954,GO:0007155,GO:0007165,GO:0007267,GO:0030335,GO:0030728,GO:0043312,GO:0050728,GO:1904724,GO:1904813 hyaluronic acid binding|extracellular region|extracellular space|inflammatory response|cell adhesion|signal transduction|cell-cell signaling|positive regulation of cell migration|ovulation|neutrophil degranulation|negative regulation of inflammatory response|tertiary granule lumen|ficolin-1-rich granule lumen TNFAIP8 131.094983725326 128.425082275588 133.764885175064 1.04157912772847 0.0587724436465789 0.83347584852279 1 1.40604 1.37819 1.52113 1.31736 GeneID:25816,Genbank:NM_001286817.1,HGNC:HGNC:17260,MIM:612111 TNF alpha induced protein 8 GO:0005654,GO:0005737,GO:0043027,GO:0043065,GO:0043066 nucleoplasm|cytoplasm|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|positive regulation of apoptotic process|negative regulation of apoptotic process TNFAIP8L1 1004.96952535868 1072.24709581136 937.691954906 0.874511069854152 -0.193451448507605 0.202484841060591 1 9.11573 9.12966 7.62644 8.52076 GeneID:126282,Genbank:XM_011527680.2,HGNC:HGNC:28279,MIM:615869 TNF alpha induced protein 8 like 1 GO:0005737,GO:0032007,GO:0042981 cytoplasm|negative regulation of TOR signaling|regulation of apoptotic process TNFAIP8L3 82.6376203312632 67.859159187578 97.4160814749484 1.43556275440532 0.521616398110736 0.105237630589723 1 0.896697 0.832614 1.31626 1.15061 GeneID:388121,Genbank:XM_017022169.1,HGNC:HGNC:20620,MIM:616438 TNF alpha induced protein 8 like 3 GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006644,GO:0008526,GO:0015914,GO:0019216,GO:0035091,GO:0042981,GO:0043552,GO:0048017,GO:0051897,GO:0070374 nucleoplasm|cytoplasm|cytosol|plasma membrane|phospholipid metabolic process|phosphatidylinositol transporter activity|phospholipid transport|regulation of lipid metabolic process|phosphatidylinositol binding|regulation of apoptotic process|positive regulation of phosphatidylinositol 3-kinase activity|inositol lipid-mediated signaling|positive regulation of protein kinase B signaling|positive regulation of ERK1 and ERK2 cascade TNFRSF10A 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0677474 GeneID:8797,Genbank:NM_003844.3,HGNC:HGNC:11904,MIM:603611 TNF receptor superfamily member 10a GO:0002020,GO:0004872,GO:0005031,GO:0005035,GO:0005622,GO:0005886,GO:0005887,GO:0006915,GO:0006919,GO:0006954,GO:0006955,GO:0007165,GO:0007166,GO:0007250,GO:0007275,GO:0008134,GO:0008625,GO:0009986,GO:0032496,GO:0036462,GO:0042127,GO:0042981,GO:0043154,GO:0045569,GO:0050900,GO:0071260,GO:0097191,GO:0097296,GO:1902041,GO:1902042 protease binding|receptor activity|tumor necrosis factor-activated receptor activity|death receptor activity|intracellular|plasma membrane|integral component of plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|immune response|signal transduction|cell surface receptor signaling pathway|activation of NF-kappaB-inducing kinase activity|multicellular organism development|transcription factor binding|extrinsic apoptotic signaling pathway via death domain receptors|cell surface|response to lipopolysaccharide|TRAIL-activated apoptotic signaling pathway|regulation of cell proliferation|regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|TRAIL binding|leukocyte migration|cellular response to mechanical stimulus|extrinsic apoptotic signaling pathway|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors hsa04060,hsa04210,hsa04217,hsa04650,hsa05162,hsa05164 Cytokine-cytokine receptor interaction|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|Measles|Influenza A TNFRSF10B 3839.18995818843 4281.42660680798 3396.95330956888 0.793416218829332 -0.333850205867129 0.0177594900445636 0.546850871863472 38.7123 41.0072 29.3836 34.3924 GeneID:8795,Genbank:NM_147187.2,HGNC:HGNC:11905,MIM:603612 TNF receptor superfamily member 10b GO:0004872,GO:0005031,GO:0005622,GO:0005886,GO:0005887,GO:0006915,GO:0006919,GO:0006954,GO:0006955,GO:0007166,GO:0007250,GO:0007275,GO:0008625,GO:0009986,GO:0032496,GO:0034976,GO:0042127,GO:0042981,GO:0043123,GO:0043154,GO:0045569,GO:0050900,GO:0070059,GO:0071260,GO:0097296,GO:1902041,GO:1902042 receptor activity|tumor necrosis factor-activated receptor activity|intracellular|plasma membrane|integral component of plasma membrane|apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|inflammatory response|immune response|cell surface receptor signaling pathway|activation of NF-kappaB-inducing kinase activity|multicellular organism development|extrinsic apoptotic signaling pathway via death domain receptors|cell surface|response to lipopolysaccharide|response to endoplasmic reticulum stress|regulation of cell proliferation|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|TRAIL binding|leukocyte migration|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to mechanical stimulus|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors hsa04060,hsa04115,hsa04210,hsa04217,hsa04650,hsa05162,hsa05164 Cytokine-cytokine receptor interaction|p53 signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|Measles|Influenza A TNFRSF10C 27.4708848881281 26.8382572480692 28.103512528187 1.04714371981843 0.0664594648472902 0.966941474866497 1 0.16508 0.390874 0.357927 0.239885 GeneID:8794,Genbank:NM_003841.4,HGNC:HGNC:11906,MIM:603613 TNF receptor superfamily member 10c GO:0004888,GO:0005031,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007165,GO:0007275,GO:0031225,GO:0032496,GO:0042127,GO:0042981,GO:0043154,GO:0045569,GO:0097190 transmembrane signaling receptor activity|tumor necrosis factor-activated receptor activity|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|signal transduction|multicellular organism development|anchored component of membrane|response to lipopolysaccharide|regulation of cell proliferation|regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|TRAIL binding|apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFRSF10D 1.27026824386655 2.05633815719933 0.484198330533773 0.235466296649008 -2.08640751970762 0.631842364882622 1 0.0285889 0.0264136 0 0.0126509 GeneID:8793,Genbank:NM_003840.4,HGNC:HGNC:11907,MIM:603614 TNF receptor superfamily member 10d GO:0004888,GO:0005031,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007165,GO:0007275,GO:0032496,GO:0042127,GO:0042981,GO:0043066,GO:0043154,GO:0045569,GO:0050900,GO:0097190 transmembrane signaling receptor activity|tumor necrosis factor-activated receptor activity|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|signal transduction|multicellular organism development|response to lipopolysaccharide|regulation of cell proliferation|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|TRAIL binding|leukocyte migration|apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFRSF11B 28.9633482662558 24.4839527876522 33.4427437448594 1.36590460024597 0.449856724068479 0.414118155373847 1 0.347438 0.414651 0.629181 0.422258 GeneID:4982,Genbank:NM_002546.3,HGNC:HGNC:11909,MIM:602643 TNF receptor superfamily member 11b hsa04060,hsa04380 Cytokine-cytokine receptor interaction|Osteoclast differentiation TNFRSF12A 6914.70675484821 7355.62984486164 6473.78366483477 0.880112757353758 -0.184239725621556 0.154360659750714 1 420.295 433.728 365.149 397.722 GeneID:51330,Genbank:NM_016639.2,HGNC:HGNC:18152,MIM:605914 TNF receptor superfamily member 12A GO:0001525,GO:0001726,GO:0005886,GO:0006931,GO:0009986,GO:0016021,GO:0033209,GO:0043065,GO:0045765,GO:0045773,GO:0061041,GO:0097191,GO:2001238 angiogenesis|ruffle|plasma membrane|substrate-dependent cell migration, cell attachment to substrate|cell surface|integral component of membrane|tumor necrosis factor-mediated signaling pathway|positive regulation of apoptotic process|regulation of angiogenesis|positive regulation of axon extension|regulation of wound healing|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFRSF13C 2.21389016201333 1.51824048055703 2.90953984346962 1.91638932088159 0.938390679157925 0.766499115284499 1 0 0.0575008 0.249948 0 GeneID:115650,Genbank:NM_052945.3,HGNC:HGNC:17755,MIM:606269 TNF receptor superfamily member 13C GO:0001782,GO:0002250,GO:0002636,GO:0005886,GO:0009897,GO:0016021,GO:0030890,GO:0031295,GO:0031296,GO:0033209,GO:0042102,GO:0045078 B cell homeostasis|adaptive immune response|positive regulation of germinal center formation|plasma membrane|external side of plasma membrane|integral component of membrane|positive regulation of B cell proliferation|T cell costimulation|B cell costimulation|tumor necrosis factor-mediated signaling pathway|positive regulation of T cell proliferation|positive regulation of interferon-gamma biosynthetic process hsa04060,hsa04064,hsa04672,hsa05166,hsa05340 Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Intestinal immune network for IgA production|Human T-cell leukemia virus 1 infection|Primary immunodeficiency TNFRSF14 6.69002338027652 5.14084539299833 8.23920136755471 1.6026938640824 0.680498877801244 0.589397092980409 1 0.0397766 0.025759 0.0458777 0.0688801 GeneID:8764,Genbank:NM_003820.3,HGNC:HGNC:11912,MIM:602746 TNF receptor superfamily member 14 hsa04060,hsa05168 Cytokine-cytokine receptor interaction|Herpes simplex infection TNFRSF18 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0199606 0 0 GeneID:8784,Genbank:XM_017002722.2,HGNC:HGNC:11914,MIM:603905 TNF receptor superfamily member 18 GO:0002687,GO:0005031,GO:0005576,GO:0005886,GO:0005887,GO:0006954,GO:0006955,GO:0007165,GO:0007275,GO:0032496,GO:0033209,GO:0042127,GO:0042531,GO:0042981,GO:0043066,GO:0045589,GO:0045785,GO:0097190 positive regulation of leukocyte migration|tumor necrosis factor-activated receptor activity|extracellular region|plasma membrane|integral component of plasma membrane|inflammatory response|immune response|signal transduction|multicellular organism development|response to lipopolysaccharide|tumor necrosis factor-mediated signaling pathway|regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|regulation of apoptotic process|negative regulation of apoptotic process|regulation of regulatory T cell differentiation|positive regulation of cell adhesion|apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFRSF19 169.623055740561 171.070085900132 168.176025580991 0.983082604396243 -0.0246154494854247 0.939044180787656 1 1.1575 1.12199 1.2212 1.10256 GeneID:55504,Genbank:XM_017020651.1,HGNC:HGNC:11915,MIM:606122 TNF receptor superfamily member 19 GO:0001942,GO:0004872,GO:0005031,GO:0005622,GO:0005886,GO:0006915,GO:0007254,GO:0009888,GO:0016021,GO:0043123,GO:0046330 hair follicle development|receptor activity|tumor necrosis factor-activated receptor activity|intracellular|plasma membrane|apoptotic process|JNK cascade|tissue development|integral component of membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade hsa04060 Cytokine-cytokine receptor interaction TNFRSF1A 2998.51589972928 2912.00922131599 3085.02257814256 1.0594137393385 0.0832661239112215 0.549503223314585 1 52.3864 52.8974 55.0769 57.958 GeneID:7132,Genbank:NM_001346091.1,HGNC:HGNC:11916,MIM:191190 TNF receptor superfamily member 1A hsa04010,hsa04060,hsa04064,hsa04071,hsa04150,hsa04210,hsa04215,hsa04217,hsa04380,hsa04668,hsa04920,hsa04931,hsa04932,hsa05010,hsa05014,hsa05142,hsa05145,hsa05152,hsa05160,hsa05163,hsa05164,hsa05165,hsa05166,hsa05167,hsa05168,hsa05170,hsa05418 MAPK signaling pathway|Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Sphingolipid signaling pathway|mTOR signaling pathway|Apoptosis|Apoptosis - multiple species|Necroptosis|Osteoclast differentiation|TNF signaling pathway|Adipocytokine signaling pathway|Insulin resistance|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Amyotrophic lateral sclerosis (ALS)|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Human cytomegalovirus infection|Influenza A|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Human immunodeficiency virus 1 infection|Fluid shear stress and atherosclerosis TNFRSF1B 0.75618370456672 1.02816907859967 0.484198330533773 0.470932593298016 -1.08640751970762 0.981148832308155 1 0.00854745 0.00756871 0 0 GeneID:7133,Genbank:XM_011542060.2,HGNC:HGNC:11917,MIM:191191 TNF receptor superfamily member 1B hsa04060,hsa04668,hsa04920,hsa05014,hsa05170 Cytokine-cytokine receptor interaction|TNF signaling pathway|Adipocytokine signaling pathway|Amyotrophic lateral sclerosis (ALS)|Human immunodeficiency virus 1 infection TNFRSF21 819.326253507666 686.193619934528 952.458887080805 1.3880322687519 0.473041107849318 0.134613450821088 1 6.73902 7.47886 12.5515 8.13254 GeneID:27242,Genbank:NM_014452.4,HGNC:HGNC:13469,MIM:605732 TNF receptor superfamily member 21 GO:0001783,GO:0002250,GO:0005031,GO:0005886,GO:0005887,GO:0006915,GO:0006954,GO:0006955,GO:0006959,GO:0019216,GO:0030424,GO:0030889,GO:0031226,GO:0031642,GO:0032496,GO:0042127,GO:0042130,GO:0042552,GO:0042981,GO:0048713,GO:0050852,GO:0051402,GO:0071356,GO:0097190,GO:0097252,GO:2000663,GO:2000666,GO:2001180 B cell apoptotic process|adaptive immune response|tumor necrosis factor-activated receptor activity|plasma membrane|integral component of plasma membrane|apoptotic process|inflammatory response|immune response|humoral immune response|regulation of lipid metabolic process|axon|negative regulation of B cell proliferation|intrinsic component of plasma membrane|negative regulation of myelination|response to lipopolysaccharide|regulation of cell proliferation|negative regulation of T cell proliferation|myelination|regulation of apoptotic process|regulation of oligodendrocyte differentiation|T cell receptor signaling pathway|neuron apoptotic process|cellular response to tumor necrosis factor|apoptotic signaling pathway|oligodendrocyte apoptotic process|negative regulation of interleukin-5 secretion|negative regulation of interleukin-13 secretion|negative regulation of interleukin-10 secretion hsa04060 Cytokine-cytokine receptor interaction TNFRSF25 73.4545932188063 74.2202787579158 72.6889076796969 0.979367214677087 -0.0300781937298668 0.968494700831848 1 1.73006 1.40262 1.06831 1.53519 GeneID:8718,Genbank:NM_148970.1,HGNC:HGNC:11910,MIM:603366 TNF receptor superfamily member 25 hsa04060 Cytokine-cytokine receptor interaction TNFRSF4 0.780196841909191 1.07619535328461 0.484198330533773 0.449916763769675 -1.15226997256519 0.981239839765731 1 0.027214 0 0 0.0117004 GeneID:7293,Genbank:XM_017002232.1,HGNC:HGNC:11918,MIM:600315 TNF receptor superfamily member 4 hsa04060 Cytokine-cytokine receptor interaction TNFRSF6B 13.0923145038112 11.1657810405415 15.0188479670809 1.3450781376197 0.427689983549255 0.633768722153923 1 0.424049 0.749268 0.448672 1.07642 GeneID:8771,Genbank:NM_003823.3,HGNC:HGNC:11921,MIM:603361 TNF receptor superfamily member 6b hsa04060 Cytokine-cytokine receptor interaction TNFRSF8 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.00944019 0.0100972 0.00945689 GeneID:943,Genbank:XM_011542441.3,HGNC:HGNC:11923,MIM:153243 TNF receptor superfamily member 8 hsa04060 Cytokine-cytokine receptor interaction TNFRSF9 80.2062021898681 128.915153677546 31.4972507021904 0.2443254326871 -2.03312404830303 3.61114292111445e-09 5.7836065024569e-06 0.684656 0.757023 0.17386 0.205489 GeneID:3604,Genbank:NM_001561.5,HGNC:HGNC:11924,MIM:602250 TNF receptor superfamily member 9 hsa04060 Cytokine-cytokine receptor interaction TNFSF10 245.262367304054 192.853741649465 297.670992958644 1.54350644386095 0.62621150595714 0.380261553998963 1 1.93185 1.84461 4.34274 1.70157 GeneID:8743,Genbank:NM_001190942.1,HGNC:HGNC:11925,MIM:603598 TNF superfamily member 10 hsa04060,hsa04068,hsa04210,hsa04217,hsa04650,hsa05162,hsa05164 Cytokine-cytokine receptor interaction|FoxO signaling pathway|Apoptosis|Necroptosis|Natural killer cell mediated cytotoxicity|Measles|Influenza A TNFSF12 271.546155958668 284.313780371005 258.778531546331 0.910186383539507 -0.135766091252067 0.546642030208696 1 16.697 18.2011 17.015 18.2625 GeneID:8742,Genbank:NM_003809.2,HGNC:HGNC:11927,MIM:602695 TNF superfamily member 12 GO:0001525,GO:0001938,GO:0005102,GO:0005125,GO:0005164,GO:0005576,GO:0005615,GO:0005886,GO:0005887,GO:0006915,GO:0006955,GO:0007165,GO:0030154,GO:0033209,GO:0043542,GO:0045732,GO:0045766,GO:0048471,GO:0097190,GO:0097191,GO:2001238 angiogenesis|positive regulation of endothelial cell proliferation|receptor binding|cytokine activity|tumor necrosis factor receptor binding|extracellular region|extracellular space|plasma membrane|integral component of plasma membrane|apoptotic process|immune response|signal transduction|cell differentiation|tumor necrosis factor-mediated signaling pathway|endothelial cell migration|positive regulation of protein catabolic process|positive regulation of angiogenesis|perinuclear region of cytoplasm|apoptotic signaling pathway|extrinsic apoptotic signaling pathway|positive regulation of extrinsic apoptotic signaling pathway hsa04060 Cytokine-cytokine receptor interaction TNFSF13 56.8033223757418 43.3369887803488 70.2696559711349 1.62147066394698 0.697302922430124 0.0723029181514916 0.929024313086611 2.70374 3.0879 4.01267 4.64731 GeneID:8741,Genbank:NM_003808.3,HGNC:HGNC:11928,MIM:604472 TNF superfamily member 13 GO:0005102,GO:0005125,GO:0005164,GO:0005576,GO:0005654,GO:0005737,GO:0005829,GO:0006955,GO:0007165,GO:0008284,GO:0016020,GO:0033209,GO:0043488,GO:0048298,GO:0070062 receptor binding|cytokine activity|tumor necrosis factor receptor binding|extracellular region|nucleoplasm|cytoplasm|cytosol|immune response|signal transduction|positive regulation of cell proliferation|membrane|tumor necrosis factor-mediated signaling pathway|regulation of mRNA stability|positive regulation of isotype switching to IgA isotypes|extracellular exosome hsa04060,hsa04672,hsa05323 Cytokine-cytokine receptor interaction|Intestinal immune network for IgA production|Rheumatoid arthritis TNFSF13B 3.98986832407103 3.13253351048394 4.84720313765811 1.54737471169439 0.629822601598113 0.736654678781669 1 0.0655678 0.0318208 0.0631019 0.0587251 GeneID:10673,Genbank:NM_006573.4,HGNC:HGNC:11929,MIM:603969 TNF superfamily member 13b hsa04060,hsa04064,hsa04672,hsa05323 Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Intestinal immune network for IgA production|Rheumatoid arthritis TNFSF14 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.00519806 0.00538638 0 GeneID:8740,Genbank:XM_017027418.1,HGNC:HGNC:11930,MIM:604520 TNF superfamily member 14 GO:0005102,GO:0005125,GO:0005164,GO:0005615,GO:0005737,GO:0005886,GO:0006915,GO:0006955,GO:0007165,GO:0008588,GO:0010820,GO:0016021,GO:0031295,GO:0033209,GO:0042098,GO:0042110,GO:0042802,GO:0043027,GO:0043029,GO:0045663,GO:0071260,GO:1901741 receptor binding|cytokine activity|tumor necrosis factor receptor binding|extracellular space|cytoplasm|plasma membrane|apoptotic process|immune response|signal transduction|release of cytoplasmic sequestered NF-kappaB|positive regulation of T cell chemotaxis|integral component of membrane|T cell costimulation|tumor necrosis factor-mediated signaling pathway|T cell proliferation|T cell activation|identical protein binding|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|T cell homeostasis|positive regulation of myoblast differentiation|cellular response to mechanical stimulus|positive regulation of myoblast fusion hsa04060,hsa04064,hsa05168 Cytokine-cytokine receptor interaction|NF-kappa B signaling pathway|Herpes simplex infection TNFSF15 8.40941932063889 14.3943671003953 2.42447154088245 0.168431965363442 -2.56976213287842 0.0190357150468358 0.565914563763644 0.072902 0.0809721 0.0233289 0.00544009 GeneID:9966,Genbank:NM_005118.3,HGNC:HGNC:11931,MIM:604052 TNF superfamily member 15 hsa04060 Cytokine-cytokine receptor interaction TNFSF18 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.073296 0 0 0.0646858 GeneID:8995,Genbank:NM_005092.3,HGNC:HGNC:11932,MIM:603898 TNF superfamily member 18 hsa04060 Cytokine-cytokine receptor interaction TNFSF4 596.206096944304 563.341619524102 629.070574364506 1.11667690183433 0.159211818274288 0.355521925604782 1 1.67895 1.94726 2.15504 1.90462 GeneID:7292,Genbank:XM_017002228.1,HGNC:HGNC:11934,MIM:603594 TNF superfamily member 4 GO:0002215,GO:0002526,GO:0002726,GO:0002819,GO:0002830,GO:0002891,GO:0005102,GO:0005125,GO:0005164,GO:0005615,GO:0005886,GO:0005887,GO:0006955,GO:0007165,GO:0008284,GO:0009615,GO:0009986,GO:0032689,GO:0032700,GO:0032729,GO:0032733,GO:0032735,GO:0032736,GO:0032753,GO:0032755,GO:0032813,GO:0033209,GO:0035709,GO:0035712,GO:0035713,GO:0042102,GO:0043372,GO:0043382,GO:0043433,GO:0045590,GO:0045626,GO:0045630,GO:0045892,GO:0046641,GO:0050727,GO:0050729,GO:0050871,GO:0051024,GO:0071222,GO:0071380,GO:0071954,GO:1900281,GO:2000572 defense response to nematode|acute inflammatory response|positive regulation of T cell cytokine production|regulation of adaptive immune response|positive regulation of type 2 immune response|positive regulation of immunoglobulin mediated immune response|receptor binding|cytokine activity|tumor necrosis factor receptor binding|extracellular space|plasma membrane|integral component of plasma membrane|immune response|signal transduction|positive regulation of cell proliferation|response to virus|cell surface|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|tumor necrosis factor receptor superfamily binding|tumor necrosis factor-mediated signaling pathway|memory T cell activation|T-helper 2 cell activation|response to nitrogen dioxide|positive regulation of T cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of memory T cell differentiation|negative regulation of DNA binding transcription factor activity|negative regulation of regulatory T cell differentiation|negative regulation of T-helper 1 cell differentiation|positive regulation of T-helper 2 cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of alpha-beta T cell proliferation|regulation of inflammatory response|positive regulation of inflammatory response|positive regulation of B cell activation|positive regulation of immunoglobulin secretion|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|positive regulation of CD4-positive, alpha-beta T cell costimulation|positive regulation of interleukin-4-dependent isotype switching to IgE isotypes hsa04060 Cytokine-cytokine receptor interaction TNFSF9 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0845328 0 0 0 GeneID:8744,Genbank:NM_003811.3,HGNC:HGNC:11939,MIM:606182 TNF superfamily member 9 GO:0005102,GO:0005125,GO:0005164,GO:0005615,GO:0005886,GO:0006915,GO:0006955,GO:0007165,GO:0007267,GO:0008283,GO:0016021,GO:0032813,GO:0033209,GO:0042104,GO:0045585 receptor binding|cytokine activity|tumor necrosis factor receptor binding|extracellular space|plasma membrane|apoptotic process|immune response|signal transduction|cell-cell signaling|cell proliferation|integral component of membrane|tumor necrosis factor receptor superfamily binding|tumor necrosis factor-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of cytotoxic T cell differentiation hsa04060 Cytokine-cytokine receptor interaction TNIK 615.825107884796 659.238675826018 572.411539943575 0.86829180528031 -0.203748126776513 0.298080155888294 1 2.22728 1.99585 2.05433 1.47338 GeneID:23043,Genbank:NM_001161566.2,HGNC:HGNC:30765,MIM:610005 TRAF2 and NCK interacting kinase GO:0001934,GO:0004672,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005856,GO:0006468,GO:0007010,GO:0007256,GO:0007346,GO:0008349,GO:0016055,GO:0016324,GO:0030033,GO:0031532,GO:0035556,GO:0042981,GO:0046777,GO:0048814,GO:0055037,GO:0070062,GO:0072659 positive regulation of protein phosphorylation|protein kinase activity|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton|protein phosphorylation|cytoskeleton organization|activation of JNKK activity|regulation of mitotic cell cycle|MAP kinase kinase kinase kinase activity|Wnt signaling pathway|apical plasma membrane|microvillus assembly|actin cytoskeleton reorganization|intracellular signal transduction|regulation of apoptotic process|protein autophosphorylation|regulation of dendrite morphogenesis|recycling endosome|extracellular exosome|protein localization to plasma membrane TNIP1 2309.76761285842 2384.02917797197 2235.50604774486 0.937700791752282 -0.0928004441269065 0.498524712732322 1 9.12418 9.19918 8.55882 8.61165 GeneID:10318,Genbank:NM_001252390.1,HGNC:HGNC:16903,MIM:607714 TNFAIP3 interacting protein 1 GO:0002755,GO:0005622,GO:0005654,GO:0005737,GO:0005829,GO:0006412,GO:0006952,GO:0006954,GO:0007159,GO:0009101,GO:0016579,GO:0031593,GO:0042802,GO:0043124,GO:0045071,GO:0045944,GO:0050729,GO:0051019,GO:0070373,GO:0071222,GO:0085032,GO:1903003 MyD88-dependent toll-like receptor signaling pathway|intracellular|nucleoplasm|cytoplasm|cytosol|translation|defense response|inflammatory response|leukocyte cell-cell adhesion|glycoprotein biosynthetic process|protein deubiquitination|polyubiquitin modification-dependent protein binding|identical protein binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|positive regulation of transcription from RNA polymerase II promoter|positive regulation of inflammatory response|mitogen-activated protein kinase binding|negative regulation of ERK1 and ERK2 cascade|cellular response to lipopolysaccharide|modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade|positive regulation of protein deubiquitination TNIP2 1168.32513677441 1166.75240714827 1169.89786640055 1.00269590980315 0.00388414240420801 0.991057867347279 1 21.7128 22.8126 23.339 21.662 GeneID:79155,Genbank:NM_001292016.1,HGNC:HGNC:19118,MIM:610669 TNFAIP3 interacting protein 2 GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006915,GO:0006954,GO:0007249,GO:0016579,GO:0019901,GO:0023035,GO:0031593,GO:0034134,GO:0034138,GO:0034162,GO:0043032,GO:0043123,GO:0045944,GO:0046872,GO:0050821,GO:0050871,GO:0051403,GO:0070498,GO:0070530,GO:0071222,GO:2000352 nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|apoptotic process|inflammatory response|I-kappaB kinase/NF-kappaB signaling|protein deubiquitination|protein kinase binding|CD40 signaling pathway|polyubiquitin modification-dependent protein binding|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 9 signaling pathway|positive regulation of macrophage activation|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|protein stabilization|positive regulation of B cell activation|stress-activated MAPK cascade|interleukin-1-mediated signaling pathway|K63-linked polyubiquitin modification-dependent protein binding|cellular response to lipopolysaccharide|negative regulation of endothelial cell apoptotic process TNIP3 1.45389994968141 0 2.90779989936283 Inf Inf 0.254628784757125 1 0 0 0.0246173 0.0229468 GeneID:79931,Genbank:NM_001244764.1,HGNC:HGNC:19315,MIM:608019 TNFAIP3 interacting protein 3 GO:0002756,GO:0005737,GO:0005829,GO:0006954,GO:0016579,GO:0019901,GO:0031593,GO:0034142,GO:0043124,GO:0045944,GO:0071222 MyD88-independent toll-like receptor signaling pathway|cytoplasm|cytosol|inflammatory response|protein deubiquitination|protein kinase binding|polyubiquitin modification-dependent protein binding|toll-like receptor 4 signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription from RNA polymerase II promoter|cellular response to lipopolysaccharide TNK1 6.67948673522915 8.51351027690698 4.84546319355132 0.569149861332135 -0.813119520151431 0.672328858701668 1 0.0553345 0.012121 0.025799 0.0361167 GeneID:8711,Genbank:XM_011524045.2,HGNC:HGNC:11940,MIM:608076 tyrosine kinase non receptor 1 GO:0004713,GO:0004715,GO:0004871,GO:0005102,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0007169,GO:0016020,GO:0016477,GO:0030154,GO:0030308,GO:0031234,GO:0038083,GO:0042127,GO:0045087,GO:0046580,GO:0046777 protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|signal transducer activity|receptor binding|ATP binding|cytoplasm|cytosol|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|membrane|cell migration|cell differentiation|negative regulation of cell growth|extrinsic component of cytoplasmic side of plasma membrane|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|innate immune response|negative regulation of Ras protein signal transduction|protein autophosphorylation TNK2 1339.22182780283 1302.59620403812 1375.84745156755 1.05623480807203 0.078930591120958 0.604737637379951 1 4.84004 4.97659 5.44693 5.3298 GeneID:10188,Genbank:XM_005269270.3,HGNC:HGNC:19297,MIM:606994 tyrosine kinase non receptor 2 GO:0004674,GO:0004712,GO:0004713,GO:0004715,GO:0005095,GO:0005154,GO:0005524,GO:0005634,GO:0005737,GO:0005768,GO:0005886,GO:0005905,GO:0005912,GO:0006897,GO:0007166,GO:0007169,GO:0007264,GO:0016020,GO:0016310,GO:0016477,GO:0030136,GO:0030154,GO:0030659,GO:0031234,GO:0031625,GO:0038083,GO:0042127,GO:0042802,GO:0045087,GO:0046872,GO:0048471,GO:0050699,GO:0050731,GO:0070436,GO:2000369 protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|GTPase inhibitor activity|epidermal growth factor receptor binding|ATP binding|nucleus|cytoplasm|endosome|plasma membrane|clathrin-coated pit|adherens junction|endocytosis|cell surface receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|small GTPase mediated signal transduction|membrane|phosphorylation|cell migration|clathrin-coated vesicle|cell differentiation|cytoplasmic vesicle membrane|extrinsic component of cytoplasmic side of plasma membrane|ubiquitin protein ligase binding|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|identical protein binding|innate immune response|metal ion binding|perinuclear region of cytoplasm|WW domain binding|positive regulation of peptidyl-tyrosine phosphorylation|Grb2-EGFR complex|regulation of clathrin-dependent endocytosis TNKS 1168.60676471938 1137.12659196676 1200.086937472 1.0553679299649 0.0777460493566044 0.679798254842276 1 3.45926 3.4195 4.21135 3.07902 GeneID:8658,Genbank:XM_006716263.4,HGNC:HGNC:11941,MIM:603303 tankyrase TNKS1BP1 2859.76854103656 2774.06105999426 2945.47602207886 1.06179206527089 0.0865012654129417 0.532759054957405 1 14.9972 14.9664 15.9406 16.3434 GeneID:85456,Genbank:NM_033396.2,HGNC:HGNC:19081,MIM:607104 tankyrase 1 binding protein 1 GO:0000289,GO:0005634,GO:0005720,GO:0005737,GO:0005829,GO:0005856,GO:0005913,GO:0006302,GO:0006977,GO:0007004,GO:0010800,GO:0019899,GO:0030014,GO:0031954,GO:0033138,GO:0044877,GO:0045296,GO:0071479,GO:0071532 nuclear-transcribed mRNA poly(A) tail shortening|nucleus|nuclear heterochromatin|cytoplasm|cytosol|cytoskeleton|cell-cell adherens junction|double-strand break repair|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|telomere maintenance via telomerase|positive regulation of peptidyl-threonine phosphorylation|enzyme binding|CCR4-NOT complex|positive regulation of protein autophosphorylation|positive regulation of peptidyl-serine phosphorylation|macromolecular complex binding|cadherin binding|cellular response to ionizing radiation|ankyrin repeat binding TNKS2 1321.02804977222 1429.29909807759 1212.75700146685 0.848497702893682 -0.237017340868839 0.373574321850522 1 6.94588 6.44273 6.99037 4.537 GeneID:80351,Genbank:NM_025235.3,HGNC:HGNC:15677,MIM:607128 tankyrase 2 GO:0000139,GO:0000209,GO:0000242,GO:0000784,GO:0003950,GO:0005634,GO:0005635,GO:0005737,GO:0005829,GO:0006471,GO:0016055,GO:0016579,GO:0019899,GO:0032212,GO:0035264,GO:0040014,GO:0046872,GO:0048471,GO:0070198,GO:0070213,GO:0090263,GO:1904355,GO:1904357 Golgi membrane|protein polyubiquitination|pericentriolar material|nuclear chromosome, telomeric region|NAD+ ADP-ribosyltransferase activity|nucleus|nuclear envelope|cytoplasm|cytosol|protein ADP-ribosylation|Wnt signaling pathway|protein deubiquitination|enzyme binding|positive regulation of telomere maintenance via telomerase|multicellular organism growth|regulation of multicellular organism growth|metal ion binding|perinuclear region of cytoplasm|protein localization to chromosome, telomeric region|protein auto-ADP-ribosylation|positive regulation of canonical Wnt signaling pathway|positive regulation of telomere capping|negative regulation of telomere maintenance via telomere lengthening TNN 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:63923,Genbank:NM_022093.1,HGNC:HGNC:22942,MIM:617472 tenascin N hsa04151,hsa04510,hsa04512,hsa05165,hsa05206 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Human papillomavirus infection|MicroRNAs in cancer TNNC1 3.26139589813687 3.13253351048394 3.39025828578981 1.08227358923482 0.11406524587363 1 1 0.112834 0.100811 0.0529374 0.245574 GeneID:7134,Genbank:NM_003280.2,HGNC:HGNC:11943,MIM:191040 troponin C1, slow skeletal and cardiac type GO:0002086,GO:0003009,GO:0005509,GO:0005861,GO:0006937,GO:0010038,GO:0014883,GO:0031013,GO:0031014,GO:0032972,GO:0042803,GO:0043462,GO:0048306,GO:0051015,GO:0055010,GO:0060048,GO:1990584 diaphragm contraction|skeletal muscle contraction|calcium ion binding|troponin complex|regulation of muscle contraction|response to metal ion|transition between fast and slow fiber|troponin I binding|troponin T binding|regulation of muscle filament sliding speed|protein homodimerization activity|regulation of ATPase activity|calcium-dependent protein binding|actin filament binding|ventricular cardiac muscle tissue morphogenesis|cardiac muscle contraction|cardiac Troponin complex hsa04020,hsa04260,hsa04261,hsa05410,hsa05414 Calcium signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) TNNC2 0.999152841887003 1.02816907859967 0.97013660517434 0.943557460895085 -0.0838177169406569 1 1 0 0.0475819 0.099388 0 GeneID:7125,Genbank:XM_011529031.2,HGNC:HGNC:11944,MIM:191039 troponin C2, fast skeletal type GO:0003009,GO:0005509,GO:0005829,GO:0005861,GO:0006937,GO:0030049,GO:0048306,GO:0051015 skeletal muscle contraction|calcium ion binding|cytosol|troponin complex|regulation of muscle contraction|muscle filament sliding|calcium-dependent protein binding|actin filament binding hsa04020 Calcium signaling pathway TNNI1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00672769 0 0 0 GeneID:7135,Genbank:NM_003281.3,HGNC:HGNC:11945,MIM:191042 troponin I1, slow skeletal type GO:0003009,GO:0003779,GO:0005829,GO:0005861,GO:0006942,GO:0014883,GO:0030049,GO:0046872,GO:0055010,GO:0060048 skeletal muscle contraction|actin binding|cytosol|troponin complex|regulation of striated muscle contraction|transition between fast and slow fiber|muscle filament sliding|metal ion binding|ventricular cardiac muscle tissue morphogenesis|cardiac muscle contraction TNNI2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.048639 0 GeneID:7136,Genbank:NM_003282.3,HGNC:HGNC:11946,MIM:191043 troponin I2, fast skeletal type GO:0003009,GO:0003779,GO:0005634,GO:0005829,GO:0005861,GO:0006937,GO:0030049,GO:0031014,GO:0045893,GO:0060048 skeletal muscle contraction|actin binding|nucleus|cytosol|troponin complex|regulation of muscle contraction|muscle filament sliding|troponin T binding|positive regulation of transcription, DNA-templated|cardiac muscle contraction TNNI3 3.94010210527929 3.03648096111406 4.84372324944452 1.5951765584815 0.67371611424006 0.738244225012949 1 0 0.123491 0.0654633 0.426104 GeneID:7137,Genbank:NM_000363.4,HGNC:HGNC:11947,MIM:191044 troponin I3, cardiac type GO:0001570,GO:0001980,GO:0003009,GO:0003779,GO:0005829,GO:0005861,GO:0006874,GO:0006940,GO:0007507,GO:0010882,GO:0019855,GO:0019901,GO:0019904,GO:0030017,GO:0030049,GO:0030172,GO:0031014,GO:0032780,GO:0046872,GO:0048306,GO:0051015,GO:0055010,GO:0060047,GO:0060048,GO:0097512,GO:1903779,GO:1990584 vasculogenesis|regulation of systemic arterial blood pressure by ischemic conditions|skeletal muscle contraction|actin binding|cytosol|troponin complex|cellular calcium ion homeostasis|regulation of smooth muscle contraction|heart development|regulation of cardiac muscle contraction by calcium ion signaling|calcium channel inhibitor activity|protein kinase binding|protein domain specific binding|sarcomere|muscle filament sliding|troponin C binding|troponin T binding|negative regulation of ATPase activity|metal ion binding|calcium-dependent protein binding|actin filament binding|ventricular cardiac muscle tissue morphogenesis|heart contraction|cardiac muscle contraction|cardiac myofibril|regulation of cardiac conduction|cardiac Troponin complex hsa04024,hsa04260,hsa04261,hsa05410,hsa05414 cAMP signaling pathway|Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) TNNT1 1128.80342787485 1145.54608369601 1112.06077205368 0.970769127389194 -0.0427998665700644 0.859944286235712 1 15.2897 15.8292 14.2237 17.9337 GeneID:7138,Genbank:NM_001126133.2,HGNC:HGNC:11948,MIM:191041 troponin T1, slow skeletal type GO:0003009,GO:0005523,GO:0005861,GO:0014883,GO:0045932 skeletal muscle contraction|tropomyosin binding|troponin complex|transition between fast and slow fiber|negative regulation of muscle contraction TNPO1 2592.24703528867 2790.14884501286 2394.34522556448 0.858142471447055 -0.220710906618528 0.40640285287094 1 17.0048 13.8456 15.288 11.1235 GeneID:3842,Genbank:NM_002270.3,HGNC:HGNC:6401,MIM:602901 transportin 1 GO:0000060,GO:0003723,GO:0005634,GO:0005737,GO:0005829,GO:0005929,GO:0006607,GO:0006610,GO:0008139,GO:0008536,GO:0008565,GO:0016032,GO:0031965,GO:0034399,GO:0035735,GO:0043488,GO:0070062 protein import into nucleus, translocation|RNA binding|nucleus|cytoplasm|cytosol|cilium|NLS-bearing protein import into nucleus|ribosomal protein import into nucleus|nuclear localization sequence binding|Ran GTPase binding|protein transporter activity|viral process|nuclear membrane|nuclear periphery|intraciliary transport involved in cilium assembly|regulation of mRNA stability|extracellular exosome TNPO2 4069.83281819366 4023.62572541821 4116.0399109691 1.02296788813311 0.032760858320536 0.822182919270908 1 26.5565 27.2445 29.5157 26.6454 GeneID:30000,Genbank:NM_001136195.1,HGNC:HGNC:19998,MIM:603002 transportin 2 GO:0000060,GO:0005634,GO:0005737,GO:0006607,GO:0006610,GO:0008139,GO:0008536,GO:0008565,GO:0031965,GO:0034399 protein import into nucleus, translocation|nucleus|cytoplasm|NLS-bearing protein import into nucleus|ribosomal protein import into nucleus|nuclear localization sequence binding|Ran GTPase binding|protein transporter activity|nuclear membrane|nuclear periphery TNPO3 4189.18439474035 4063.07629259906 4315.29249688165 1.06207518296961 0.0868858963287345 0.509865683968026 1 34.0049 32.7279 38.1562 33.5255 GeneID:23534,Genbank:NM_001191028.2,HGNC:HGNC:17103,MIM:610032 transportin 3 GO:0004872,GO:0005737,GO:0008139,GO:0008565,GO:0031965,GO:0035048,GO:0042802,GO:0043231 receptor activity|cytoplasm|nuclear localization sequence binding|protein transporter activity|nuclear membrane|splicing factor protein import into nucleus|identical protein binding|intracellular membrane-bounded organelle TNRC18 2035.02716849444 1909.41111651322 2160.64322047566 1.13157569985306 0.178333100865971 0.330450223381462 1 5.18873 5.87072 7.08221 5.67988 GeneID:84629,Genbank:XM_017012737.2,HGNC:HGNC:11962 trinucleotide repeat containing 18 GO:0000785,GO:0000976,GO:0003682,GO:0005634,GO:0005654,GO:0005677,GO:0005739,GO:0005829,GO:0006342,GO:0031507,GO:0031965 chromatin|transcription regulatory region sequence-specific DNA binding|chromatin binding|nucleus|nucleoplasm|chromatin silencing complex|mitochondrion|cytosol|chromatin silencing|heterochromatin assembly|nuclear membrane TNRC6A 815.649121234796 939.111370613228 692.186871856363 0.737065798068629 -0.440134680030891 0.164451042391466 1 3.6644 3.09353 3.1662 1.87677 GeneID:27327,Genbank:NM_001351850.1,HGNC:HGNC:11969,MIM:610739 trinucleotide repeat containing 6A GO:0000932,GO:0003723,GO:0005654,GO:0005794,GO:0005829,GO:0007223,GO:0035068,GO:0035194,GO:0035195,GO:0035278,GO:0043231,GO:0045652,GO:0060964 P-body|RNA binding|nucleoplasm|Golgi apparatus|cytosol|Wnt signaling pathway, calcium modulating pathway|micro-ribonucleoprotein complex|posttranscriptional gene silencing by RNA|gene silencing by miRNA|miRNA mediated inhibition of translation|intracellular membrane-bounded organelle|regulation of megakaryocyte differentiation|regulation of gene silencing by miRNA TNRC6B 613.236307965238 609.473940891285 616.998675039191 1.01234627708102 0.0177028540415941 0.914531863686947 1 1.16982 1.18188 1.35719 1.0257 GeneID:23112,Genbank:NM_001024843.1,HGNC:HGNC:29190,MIM:610740 trinucleotide repeat containing 6B GO:0000932,GO:0003723,GO:0005829,GO:0007223,GO:0031047,GO:0035194,GO:0035278,GO:0045652,GO:0060213,GO:1900153 P-body|RNA binding|cytosol|Wnt signaling pathway, calcium modulating pathway|gene silencing by RNA|posttranscriptional gene silencing by RNA|miRNA mediated inhibition of translation|regulation of megakaryocyte differentiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TNRC6C 275.348912065071 262.798664959566 287.899159170575 1.09551225922274 0.131605628756159 0.542257787140942 1 0.535684 0.632382 0.734705 0.536621 GeneID:57690,Genbank:XM_024450848.1,HGNC:HGNC:29318,MIM:610741 trinucleotide repeat containing 6C GO:0003723,GO:0005829,GO:0007223,GO:0035194,GO:0035195,GO:0035278,GO:0045652,GO:0060213,GO:1900153 RNA binding|cytosol|Wnt signaling pathway, calcium modulating pathway|posttranscriptional gene silencing by RNA|gene silencing by miRNA|miRNA mediated inhibition of translation|regulation of megakaryocyte differentiation|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TNS1 2.81002031208096 4.65077399104097 0.969266633120943 0.208409747493233 -2.26250533967362 0.294673429669323 1 0.0114442 0.00509338 0.0026744 0.0025025 GeneID:7145,Genbank:XM_024453083.1,HGNC:HGNC:11973,MIM:600076 tensin 1 GO:0003723,GO:0003779,GO:0005737,GO:0005856,GO:0005925,GO:0007044,GO:0009986,GO:0010761 RNA binding|actin binding|cytoplasm|cytoskeleton|focal adhesion|cell-substrate junction assembly|cell surface|fibroblast migration TNS2 178.887577036752 170.72409332223 187.051060751274 1.09563364555832 0.131765475222038 0.575226290412336 1 0.902868 0.747429 0.793508 1.0764 GeneID:23371,Genbank:XM_017019089.1,HGNC:HGNC:19737,MIM:607717 tensin 2 GO:0001822,GO:0004721,GO:0005622,GO:0005886,GO:0005925,GO:0008285,GO:0014850,GO:0019725,GO:0019900,GO:0032963,GO:0035264,GO:0035556,GO:0046872,GO:0048871 kidney development|phosphoprotein phosphatase activity|intracellular|plasma membrane|focal adhesion|negative regulation of cell proliferation|response to muscle activity|cellular homeostasis|kinase binding|collagen metabolic process|multicellular organism growth|intracellular signal transduction|metal ion binding|multicellular organismal homeostasis TNS3 9081.17213167043 8873.33964104198 9289.00462229888 1.04684425459545 0.0660468196933291 0.617817545464076 1 22.1887 22.3197 24.7829 22.9955 GeneID:64759,Genbank:XM_011515477.2,HGNC:HGNC:21616,MIM:606825 tensin 3 GO:0005829,GO:0005925,GO:0008284,GO:0016477,GO:0048286 cytosol|focal adhesion|positive regulation of cell proliferation|cell migration|lung alveolus development TNS4 2.75318443026063 3.084507235799 2.42186162472226 0.785169701213202 -0.34892359293509 0.960565921193595 1 0.0231453 0.0202285 0 0.0134217 GeneID:84951,Genbank:XM_005257744.1,HGNC:HGNC:24352,MIM:608385 tensin 4 TNXB 7.477724871241 7.68725495215503 7.26819479032697 0.945486371346306 -0.0808714321991647 1 1 0.0118882 0.00760199 0.00820081 0.0128295 GeneID:7148,Genbank:NM_019105.6,HGNC:HGNC:11976,MIM:600985 tenascin XB GO:0005178,GO:0005576,GO:0005578,GO:0005615,GO:0005622,GO:0007155,GO:0008201,GO:0030036,GO:0030199,GO:0031012,GO:0032963,GO:0048251,GO:0070062 integrin binding|extracellular region|proteinaceous extracellular matrix|extracellular space|intracellular|cell adhesion|heparin binding|actin cytoskeleton organization|collagen fibril organization|extracellular matrix|collagen metabolic process|elastic fiber assembly|extracellular exosome hsa04151,hsa04510,hsa04512,hsa05165,hsa05206 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Human papillomavirus infection|MicroRNAs in cancer TOB1 1561.77072454113 1557.20569998675 1566.3357490955 1.00586309766836 0.00843396145039086 0.943084460047527 1 30.805 29.1643 31.3929 29.3902 GeneID:10140,Genbank:NM_001243877.1,HGNC:HGNC:11979,MIM:605523 transducer of ERBB2, 1 GO:0003714,GO:0005070,GO:0005634,GO:0005737,GO:0007184,GO:0008285,GO:0017148,GO:0030014,GO:0030509,GO:0030514,GO:0030971,GO:0045668,GO:0046332,GO:0060212,GO:0060213,GO:1900153 transcription corepressor activity|SH3/SH2 adaptor activity|nucleus|cytoplasm|SMAD protein import into nucleus|negative regulation of cell proliferation|negative regulation of translation|CCR4-NOT complex|BMP signaling pathway|negative regulation of BMP signaling pathway|receptor tyrosine kinase binding|negative regulation of osteoblast differentiation|SMAD binding|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay hsa03018 RNA degradation TOB2 987.431168568614 1027.92015557199 946.942181565239 0.92122153304632 -0.118379961159918 0.440106645096652 1 5.69309 5.57604 5.28487 5.37398 GeneID:10766,Genbank:NM_016272.3,HGNC:HGNC:11980,MIM:607396 transducer of ERBB2, 2 GO:0003714,GO:0005634,GO:0005737,GO:0005829,GO:0007292,GO:0008285,GO:0010468,GO:0023052,GO:0042809,GO:0045671,GO:0045778 transcription corepressor activity|nucleus|cytoplasm|cytosol|female gamete generation|negative regulation of cell proliferation|regulation of gene expression|signaling|vitamin D receptor binding|negative regulation of osteoclast differentiation|positive regulation of ossification hsa03018 RNA degradation TOE1 577.66136123776 613.981653059126 541.341069416394 0.881689325274126 -0.181657701965333 0.269649968583681 1 7.1261 8.08659 7.00194 6.68519 GeneID:114034,Genbank:NM_025077.3,HGNC:HGNC:15954,MIM:613931 target of EGR1, exonuclease GO:0000175,GO:0004535,GO:0005654,GO:0005730,GO:0005737,GO:0015030,GO:0016604,GO:0016607,GO:0017069,GO:0034472,GO:0046872,GO:0090503 3'-5'-exoribonuclease activity|poly(A)-specific ribonuclease activity|nucleoplasm|nucleolus|cytoplasm|Cajal body|nuclear body|nuclear speck|snRNA binding|snRNA 3'-end processing|metal ion binding|RNA phosphodiester bond hydrolysis, exonucleolytic TOGARAM1 116.582162701329 129.933514101038 103.230811301621 0.794489489611952 -0.331899960757258 0.248495755719813 1 0.79459 0.687929 0.649274 0.517711 GeneID:23116,Genbank:NM_001308120.1,HGNC:HGNC:19959,MIM:617618 TOG array regulator of axonemal microtubules 1 GO:0005737,GO:0005929,GO:0031116,GO:0035082,GO:0036064,GO:1905515 cytoplasm|cilium|positive regulation of microtubule polymerization|axoneme assembly|ciliary basal body|non-motile cilium assembly TOGARAM2 1.74946347503013 1.07619535328461 2.42273159677566 2.25120057374467 1.17069460137475 0.729443551161772 1 0.0134701 0 0.0126229 0.0176898 GeneID:165186,Genbank:NM_199280.2,HGNC:HGNC:33715 TOG array regulator of axonemal microtubules 2 TOLLIP 1169.55143470502 1143.01827444621 1196.08459496383 1.04642648477631 0.0654709606389024 0.675172209952025 1 10.9222 11.0185 12.2327 11.6182 GeneID:54472,Genbank:NM_001318512.1,HGNC:HGNC:16476,MIM:606277 toll interacting protein GO:0004871,GO:0005150,GO:0005576,GO:0005737,GO:0005829,GO:0006511,GO:0006914,GO:0006954,GO:0007165,GO:0007267,GO:0016310,GO:0016604,GO:0019900,GO:0030855,GO:0031624,GO:0031625,GO:0032183,GO:0033235,GO:0035325,GO:0035556,GO:0035578,GO:0035580,GO:0036010,GO:0043130,GO:0043312,GO:0045087,GO:0045092,GO:0045321,GO:0045323,GO:0048471,GO:0070062,GO:0070498 signal transducer activity|interleukin-1, Type I receptor binding|extracellular region|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|autophagy|inflammatory response|signal transduction|cell-cell signaling|phosphorylation|nuclear body|kinase binding|epithelial cell differentiation|ubiquitin conjugating enzyme binding|ubiquitin protein ligase binding|SUMO binding|positive regulation of protein sumoylation|Toll-like receptor binding|intracellular signal transduction|azurophil granule lumen|specific granule lumen|protein localization to endosome|ubiquitin binding|neutrophil degranulation|innate immune response|interleukin-18 receptor complex|leukocyte activation|interleukin-1 receptor complex|perinuclear region of cytoplasm|extracellular exosome|interleukin-1-mediated signaling pathway hsa04620 Toll-like receptor signaling pathway TOM1 556.883962304414 513.825807617047 599.942116991781 1.16759825625364 0.223543961365537 0.193351000663881 1 6.14357 6.18866 7.37202 7.47278 GeneID:10043,Genbank:NM_001135729.1,HGNC:HGNC:11982,MIM:604700 target of myb1 membrane trafficking protein GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0006886,GO:0006897,GO:0015031,GO:0016020,GO:0016197,GO:0030276,GO:0035577,GO:0035579,GO:0043312,GO:0070062 cytoplasm|endosome|early endosome|cytosol|plasma membrane|intracellular protein transport|endocytosis|protein transport|membrane|endosomal transport|clathrin binding|azurophil granule membrane|specific granule membrane|neutrophil degranulation|extracellular exosome TOM1L1 540.25914939271 553.221590870667 527.296707914754 0.9531383384457 -0.0692424728766509 0.722952741724875 1 4.78252 4.30457 4.52085 4.06778 GeneID:10040,Genbank:NM_001321175.1,HGNC:HGNC:11983,MIM:604701 target of myb1 like 1 membrane trafficking protein GO:0005737,GO:0005764,GO:0005768,GO:0005795,GO:0005829,GO:0006886,GO:0007165,GO:0010008,GO:0017124,GO:0019901,GO:0030276,GO:0030295,GO:0031954,GO:0032147,GO:0043130,GO:0043162,GO:0045839,GO:0070062 cytoplasm|lysosome|endosome|Golgi stack|cytosol|intracellular protein transport|signal transduction|endosome membrane|SH3 domain binding|protein kinase binding|clathrin binding|protein kinase activator activity|positive regulation of protein autophosphorylation|activation of protein kinase activity|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|negative regulation of mitotic nuclear division|extracellular exosome TOM1L2 4333.77615165477 4289.37666144634 4378.17564186319 1.02070207105265 0.0295618247483824 0.852698374340374 1 26.3663 29.3159 29.6009 28.042 GeneID:146691,Genbank:NM_001288789.1,HGNC:HGNC:11984,MIM:615519 target of myb1 like 2 membrane trafficking protein GO:0005622,GO:0006886,GO:0007165,GO:0019901,GO:0030276,GO:0045839,GO:0070062 intracellular|intracellular protein transport|signal transduction|protein kinase binding|clathrin binding|negative regulation of mitotic nuclear division|extracellular exosome TOMM20 3145.83023463852 3447.31665037573 2844.3438189013 0.825089223698463 -0.277377956586927 0.043534704262047 0.780326589998453 50.6762 49.1698 43.5149 39.5915 GeneID:9804,Genbank:NM_014765.2,HGNC:HGNC:20947,MIM:601848 translocase of outer mitochondrial membrane 20 GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0014850,GO:0015450,GO:0016031,GO:0016236,GO:0016579,GO:0030150,GO:0030943,GO:0031012,GO:0031307,GO:0044233,GO:0051082,GO:0070096,GO:1905242 mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|response to muscle activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|tRNA import into mitochondrion|macroautophagy|protein deubiquitination|protein import into mitochondrial matrix|mitochondrion targeting sequence binding|extracellular matrix|integral component of mitochondrial outer membrane|ER-mitochondrion membrane contact site|unfolded protein binding|mitochondrial outer membrane translocase complex assembly|response to 3,3',5-triiodo-L-thyronine TOMM20L 3.16827988447878 3.43049981370153 2.90605995525603 0.847124358861391 -0.239354320438467 0.965096350062323 1 0 0 0 0.137378 GeneID:387990,Genbank:XM_011536743.2,HGNC:HGNC:33752 translocase of outer mitochondrial membrane 20 like GO:0005742,GO:0015450,GO:0016031,GO:0030150,GO:0030943,GO:0031307,GO:0070096 mitochondrial outer membrane translocase complex|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|tRNA import into mitochondrion|protein import into mitochondrial matrix|mitochondrion targeting sequence binding|integral component of mitochondrial outer membrane|mitochondrial outer membrane translocase complex assembly TOMM22 1771.39998263765 1622.86545919393 1919.93450608137 1.18305217182637 0.242513696987518 0.141804360846164 1 51.585 51.9388 57.1761 66.1043 GeneID:56993,Genbank:NM_020243.4,HGNC:HGNC:18002,MIM:607046 translocase of outer mitochondrial membrane 22 GO:0005739,GO:0005741,GO:0005742,GO:0005743,GO:0006626,GO:0008320,GO:0016020,GO:0016021,GO:0016236,GO:0030150,GO:0031307,GO:0043065,GO:0045040,GO:0051204 mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|mitochondrial inner membrane|protein targeting to mitochondrion|protein transmembrane transporter activity|membrane|integral component of membrane|macroautophagy|protein import into mitochondrial matrix|integral component of mitochondrial outer membrane|positive regulation of apoptotic process|protein import into mitochondrial outer membrane|protein insertion into mitochondrial membrane TOMM34 2005.17362112041 1814.39408246243 2195.95315977838 1.21029559179233 0.275359441493806 0.0515911193474777 0.830435545195178 19.9169 20.0975 28.1701 24.0902 GeneID:10953,Genbank:NM_006809.4,HGNC:HGNC:15746,MIM:616049 translocase of outer mitochondrial membrane 34 GO:0005634,GO:0005654,GO:0005741,GO:0005829,GO:0006626,GO:0016020,GO:0016021,GO:0031072 nucleus|nucleoplasm|mitochondrial outer membrane|cytosol|protein targeting to mitochondrion|membrane|integral component of membrane|heat shock protein binding TOMM40 4276.84145559598 4441.27511073949 4112.40780045247 0.925952051587216 -0.110990606292075 0.39417952287169 1 77.1192 79.9308 74.14 75.8736 GeneID:10452,Genbank:NM_001128917.1,HGNC:HGNC:18001,MIM:608061 translocase of outer mitochondrial membrane 40 GO:0005739,GO:0005741,GO:0005742,GO:0005743,GO:0005829,GO:0006626,GO:0006811,GO:0008320,GO:0015266,GO:0015288,GO:0016021,GO:0016236,GO:0030150,GO:0031307,GO:0046930,GO:0070062 mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|mitochondrial inner membrane|cytosol|protein targeting to mitochondrion|ion transport|protein transmembrane transporter activity|protein channel activity|porin activity|integral component of membrane|macroautophagy|protein import into mitochondrial matrix|integral component of mitochondrial outer membrane|pore complex|extracellular exosome hsa05014 Amyotrophic lateral sclerosis (ALS) TOMM40L 737.209665900316 739.745672916827 734.673658883806 0.993143570528744 -0.00992580360129515 0.921602436552132 1 8.22308 10.0865 9.23368 9.43334 GeneID:84134,Genbank:NM_032174.5,HGNC:HGNC:25756 translocase of outer mitochondrial membrane 40 like GO:0005742,GO:0006811,GO:0015266,GO:0015288,GO:0030150,GO:0030943,GO:0043234,GO:0046930,GO:0070678 mitochondrial outer membrane translocase complex|ion transport|protein channel activity|porin activity|protein import into mitochondrial matrix|mitochondrion targeting sequence binding|protein complex|pore complex|preprotein binding hsa05014 Amyotrophic lateral sclerosis (ALS) TOMM5 2715.3493748292 2935.45621337079 2495.24253628762 0.850035686079039 -0.234404685344619 0.0841422111125923 0.963274948662815 82.9332 83.3372 71.39 76.189 GeneID:401505,Genbank:NM_001001790.2,HGNC:HGNC:31369,MIM:616169 translocase of outer mitochondrial membrane 5 GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0016021,GO:0016236 mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|integral component of membrane|macroautophagy TOMM6 2614.42361865615 2585.85809233583 2642.98914497648 1.02209365348005 0.0315273951217957 0.827745931070701 1 93.6196 96.8952 95.7797 103.378 GeneID:100188893,Genbank:NM_001134493.1,HGNC:HGNC:34528,MIM:616168 translocase of outer mitochondrial membrane 6 GO:0005739,GO:0005741,GO:0005742,GO:0015031,GO:0016236 mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein transport|macroautophagy TOMM7 2682.22702847827 2684.755445981 2679.69861097554 0.998116463451812 -0.0027199311871893 0.980548357680935 1 161.875 177.775 153.499 186.247 GeneID:54543,Genbank:NM_019059.3,HGNC:HGNC:21648,MIM:607980 translocase of outer mitochondrial membrane 7 GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0008320,GO:0016236,GO:0030150,GO:0031307,GO:0031647,GO:0045040,GO:0098779,GO:1903955 mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|macroautophagy|protein import into mitochondrial matrix|integral component of mitochondrial outer membrane|regulation of protein stability|protein import into mitochondrial outer membrane|positive regulation of mitophagy in response to mitochondrial depolarization|positive regulation of protein targeting to mitochondrion hsa04137 Mitophagy - animal TOMM70 1398.0133580419 1466.14069711866 1329.88601896514 0.907065755407177 -0.140720955863151 0.342718512878968 1 13.669 13.2954 13.5328 11.3907 GeneID:9868,Genbank:NM_014820.4,HGNC:HGNC:11985,MIM:606081 translocase of outer mitochondrial membrane 70 GO:0005739,GO:0005741,GO:0005742,GO:0006626,GO:0008320,GO:0016020,GO:0016021,GO:0016236,GO:0070062 mitochondrion|mitochondrial outer membrane|mitochondrial outer membrane translocase complex|protein targeting to mitochondrion|protein transmembrane transporter activity|membrane|integral component of membrane|macroautophagy|extracellular exosome TONSL 885.164529917941 880.613628339235 889.715431496647 1.01033575096331 0.014834803626695 0.937469433807516 1 7.19529 6.89972 6.87749 7.83541 GeneID:4796,Genbank:NM_013432.4,HGNC:HGNC:7801,MIM:604546 tonsoku like, DNA repair protein GO:0000724,GO:0003714,GO:0005654,GO:0005737,GO:0016604,GO:0031297,GO:0042393,GO:0042994,GO:0043596 double-strand break repair via homologous recombination|transcription corepressor activity|nucleoplasm|cytoplasm|nuclear body|replication fork processing|histone binding|cytoplasmic sequestering of transcription factor|nuclear replication fork TOP1 2108.71201038738 2196.83069407851 2020.59332669624 0.91977653632694 -0.120644700122911 0.510503306511215 1 17.2925 15.4717 17.1605 13.2707 GeneID:7150,Genbank:NM_003286.3,HGNC:HGNC:11986,MIM:126420 DNA topoisomerase I TOP1MT 425.31245206691 427.075394817196 423.549509316624 0.991744114637929 -0.0119601639565515 0.935787460417294 1 4.35914 4.9056 4.8915 4.909 GeneID:116447,Genbank:NM_001258447.1,HGNC:HGNC:29787,MIM:606387 DNA topoisomerase I mitochondrial GO:0003677,GO:0003917,GO:0005634,GO:0005694,GO:0005739,GO:0006260,GO:0006265,GO:0042645 DNA binding|DNA topoisomerase type I activity|nucleus|chromosome|mitochondrion|DNA replication|DNA topological change|mitochondrial nucleoid TOP2A 3435.64503999775 3527.7979281512 3343.4921518443 0.947756141349205 -0.0774121949656328 0.803278689034969 1 17.4513 15.2712 18.897 12.4261 GeneID:7153,Genbank:NM_001067.3,HGNC:HGNC:11989,MIM:126430 DNA topoisomerase II alpha GO:0000287,GO:0000712,GO:0000793,GO:0000819,GO:0002244,GO:0003677,GO:0003682,GO:0003723,GO:0003918,GO:0005080,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006265,GO:0006266,GO:0006974,GO:0007059,GO:0008022,GO:0008094,GO:0008144,GO:0008301,GO:0009330,GO:0016925,GO:0019899,GO:0030263,GO:0030529,GO:0040016,GO:0042752,GO:0042803,GO:0042826,GO:0043065,GO:0043130,GO:0043234,GO:0044774,GO:0045070,GO:0045870,GO:0045944,GO:0046982,GO:0048511,GO:1905463 magnesium ion binding|resolution of meiotic recombination intermediates|condensed chromosome|sister chromatid segregation|hematopoietic progenitor cell differentiation|DNA binding|chromatin binding|RNA binding|DNA topoisomerase type II (ATP-hydrolyzing) activity|protein kinase C binding|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA topological change|DNA ligation|cellular response to DNA damage stimulus|chromosome segregation|protein C-terminus binding|DNA-dependent ATPase activity|drug binding|DNA binding, bending|DNA topoisomerase complex (ATP-hydrolyzing)|protein sumoylation|enzyme binding|apoptotic chromosome condensation|intracellular ribonucleoprotein complex|embryonic cleavage|regulation of circadian rhythm|protein homodimerization activity|histone deacetylase binding|positive regulation of apoptotic process|ubiquitin binding|protein complex|mitotic DNA integrity checkpoint|positive regulation of viral genome replication|positive regulation of single stranded viral RNA replication via double stranded DNA intermediate|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|rhythmic process|negative regulation of DNA duplex unwinding hsa01524 Platinum drug resistance TOP2B 739.719240835533 738.790888074817 740.64759359625 1.00251316786848 0.00362118639968317 0.971069022334707 1 4.31798 3.40047 5.13716 3.18941 GeneID:7155,Genbank:NM_001330700.1,HGNC:HGNC:11990,MIM:126431 DNA topoisomerase II beta GO:0000712,GO:0000819,GO:0001764,GO:0003677,GO:0003682,GO:0003918,GO:0005080,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006265,GO:0007409,GO:0008022,GO:0016925,GO:0019899,GO:0030529,GO:0030900,GO:0042826,GO:0043021,GO:0044774,GO:0046872,GO:0046982 resolution of meiotic recombination intermediates|sister chromatid segregation|neuron migration|DNA binding|chromatin binding|DNA topoisomerase type II (ATP-hydrolyzing) activity|protein kinase C binding|ATP binding|nucleus|nucleoplasm|cytosol|DNA topological change|axonogenesis|protein C-terminus binding|protein sumoylation|enzyme binding|intracellular ribonucleoprotein complex|forebrain development|histone deacetylase binding|ribonucleoprotein complex binding|mitotic DNA integrity checkpoint|metal ion binding|protein heterodimerization activity hsa01524 Platinum drug resistance TOP3A 1847.74732087899 1820.46704438466 1875.02759737332 1.02997063481976 0.0426032057542855 0.7743052055804 1 7.38446 7.93636 8.22143 7.81779 GeneID:7156,Genbank:XM_024450903.1,HGNC:HGNC:11992,MIM:601243 DNA topoisomerase III alpha GO:0000731,GO:0000732,GO:0003677,GO:0003917,GO:0005634,GO:0005654,GO:0005694,GO:0006260,GO:0006265,GO:0008270,GO:0016605,GO:0051321,GO:1901796 DNA synthesis involved in DNA repair|strand displacement|DNA binding|DNA topoisomerase type I activity|nucleus|nucleoplasm|chromosome|DNA replication|DNA topological change|zinc ion binding|PML body|meiotic cell cycle|regulation of signal transduction by p53 class mediator hsa03440,hsa03460 Homologous recombination|Fanconi anemia pathway TOP3B 442.598469918648 432.572041443205 452.624898394092 1.04635726544874 0.0653755256656178 0.748152720804222 1 2.06393 2.37486 2.31771 2.38723 GeneID:8940,Genbank:XM_017029038.2,HGNC:HGNC:11993,MIM:603582 DNA topoisomerase III beta GO:0000793,GO:0003677,GO:0003723,GO:0003916,GO:0003917,GO:0005634,GO:0006265,GO:0007059 condensed chromosome|DNA binding|RNA binding|DNA topoisomerase activity|DNA topoisomerase type I activity|nucleus|DNA topological change|chromosome segregation hsa03440,hsa03460 Homologous recombination|Fanconi anemia pathway TOPBP1 674.326849537292 744.710979518737 603.942719555847 0.810975984194754 -0.302268903004792 0.246666461078325 1 4.65421 3.98602 4.18044 2.87896 GeneID:11073,Genbank:NM_007027.3,HGNC:HGNC:17008,MIM:607760 DNA topoisomerase II binding protein 1 GO:0000794,GO:0000922,GO:0001673,GO:0003677,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005815,GO:0006259,GO:0006260,GO:0006270,GO:0006281,GO:0006974,GO:0007095,GO:0008022,GO:0010212,GO:0015629,GO:0016604,GO:0016605,GO:0033314,GO:0042802,GO:1901796 condensed nuclear chromosome|spindle pole|male germ cell nucleus|DNA binding|nucleus|nucleoplasm|chromosome|cytoplasm|microtubule organizing center|DNA metabolic process|DNA replication|DNA replication initiation|DNA repair|cellular response to DNA damage stimulus|mitotic G2 DNA damage checkpoint|protein C-terminus binding|response to ionizing radiation|actin cytoskeleton|nuclear body|PML body|mitotic DNA replication checkpoint|identical protein binding|regulation of signal transduction by p53 class mediator hsa03440 Homologous recombination TOPORS 396.404601651322 405.040782038476 387.768421264168 0.957356489666597 -0.0628718555402044 0.836522962370442 1 3.25995 3.02206 3.6958 2.37282 GeneID:10210,Genbank:NM_001195622.1,HGNC:HGNC:21653,MIM:609507 TOP1 binding arginine/serine rich protein TOR1A 1394.84897662528 1417.28947840379 1372.40847484677 0.968333213333688 -0.0464245158757622 0.747090926785734 1 25.0146 26.3721 25.2123 26.0681 GeneID:1861,Genbank:NM_000113.2,HGNC:HGNC:3098,MIM:605204 torsin family 1 member A GO:0000338,GO:0005524,GO:0005635,GO:0005783,GO:0005788,GO:0005829,GO:0005856,GO:0006979,GO:0006996,GO:0006998,GO:0007155,GO:0008021,GO:0008092,GO:0016020,GO:0016887,GO:0019894,GO:0030054,GO:0030141,GO:0030426,GO:0030659,GO:0031175,GO:0031965,GO:0034504,GO:0042406,GO:0043231,GO:0044319,GO:0045104,GO:0048489,GO:0051082,GO:0051085,GO:0051260,GO:0051584,GO:0051787,GO:0061077,GO:0070062,GO:0071712,GO:0071763,GO:0072321,GO:1900244,GO:2000008 protein deneddylation|ATP binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum lumen|cytosol|cytoskeleton|response to oxidative stress|organelle organization|nuclear envelope organization|cell adhesion|synaptic vesicle|cytoskeletal protein binding|membrane|ATPase activity|kinesin binding|cell junction|secretory granule|growth cone|cytoplasmic vesicle membrane|neuron projection development|nuclear membrane|protein localization to nucleus|extrinsic component of endoplasmic reticulum membrane|intracellular membrane-bounded organelle|wound healing, spreading of cells|intermediate filament cytoskeleton organization|synaptic vesicle transport|unfolded protein binding|chaperone cofactor-dependent protein refolding|protein homooligomerization|regulation of dopamine uptake involved in synaptic transmission|misfolded protein binding|chaperone-mediated protein folding|extracellular exosome|ER-associated misfolded protein catabolic process|nuclear membrane organization|chaperone-mediated protein transport|positive regulation of synaptic vesicle endocytosis|regulation of protein localization to cell surface TOR1AIP1 1132.05962957693 1164.36664272082 1099.75261643305 0.944507147562404 -0.0823663806307128 0.744744602320504 1 9.5666 7.87663 9.77419 7.39492 GeneID:26092,Genbank:NM_001267578.1,HGNC:HGNC:29456,MIM:614512 torsin 1A interacting protein 1 GO:0001671,GO:0005521,GO:0005634,GO:0005637,GO:0008092,GO:0016021,GO:0031965,GO:0032781,GO:0034504,GO:0051117,GO:0071763 ATPase activator activity|lamin binding|nucleus|nuclear inner membrane|cytoskeletal protein binding|integral component of membrane|nuclear membrane|positive regulation of ATPase activity|protein localization to nucleus|ATPase binding|nuclear membrane organization TOR1AIP2 955.610853431196 1010.66077829815 900.560928564244 0.89106151925743 -0.166403055436739 0.476634940644275 1 2.65007 2.33896 2.68849 1.85622 GeneID:163590,Genbank:NM_001349936.1,HGNC:HGNC:24055,MIM:614513 torsin 1A interacting protein 2 GO:0001671,GO:0005783,GO:0005789,GO:0007029,GO:0016021,GO:0031965,GO:0032781,GO:0051117,GO:0090435 ATPase activator activity|endoplasmic reticulum|endoplasmic reticulum membrane|endoplasmic reticulum organization|integral component of membrane|nuclear membrane|positive regulation of ATPase activity|ATPase binding|protein localization to nuclear envelope TOR1B 804.008745893758 811.764517692634 796.252974094881 0.980891572297539 -0.0278344250627201 0.857246115392812 1 11.3574 11.8725 11.9916 11.1715 GeneID:27348,Genbank:NM_014506.2,HGNC:HGNC:11995,MIM:608050 torsin family 1 member B GO:0005524,GO:0005635,GO:0005783,GO:0005788,GO:0006986,GO:0007029,GO:0016887,GO:0031965,GO:0051085,GO:0051260,GO:0070062,GO:0071763 ATP binding|nuclear envelope|endoplasmic reticulum|endoplasmic reticulum lumen|response to unfolded protein|endoplasmic reticulum organization|ATPase activity|nuclear membrane|chaperone cofactor-dependent protein refolding|protein homooligomerization|extracellular exosome|nuclear membrane organization TOR2A 146.620642741923 133.806059042011 159.435226441834 1.19153966257818 0.252826975072025 0.316730840333517 1 2.77889 2.59685 3.33921 3.63559 GeneID:27433,Genbank:NM_001252021.1,HGNC:HGNC:11996,MIM:608052 torsin family 2 member A GO:0005524,GO:0005788,GO:0051085,GO:0051260 ATP binding|endoplasmic reticulum lumen|chaperone cofactor-dependent protein refolding|protein homooligomerization TOR3A 1078.65553159916 1050.92408549866 1106.38697769966 1.05277535548601 0.0741976224017239 0.622495571378747 1 19.582 19.2345 21.2324 20.6409 GeneID:64222,Genbank:NM_022371.3,HGNC:HGNC:11997,MIM:607555 torsin family 3 member A GO:0005524,GO:0005783,GO:0005788,GO:0016887,GO:0070062 ATP binding|endoplasmic reticulum|endoplasmic reticulum lumen|ATPase activity|extracellular exosome TOR4A 1428.00539545562 1274.24072331035 1581.77006760089 1.24134320828455 0.311902048936953 0.0351569831959096 0.734125479616282 18.5798 19.9519 23.986 25.0613 GeneID:54863,Genbank:NM_017723.2,HGNC:HGNC:25981 torsin family 4 member A GO:0002576,GO:0005524,GO:0005576,GO:0016021,GO:0031093 platelet degranulation|ATP binding|extracellular region|integral component of membrane|platelet alpha granule lumen TOX 406.136379323859 408.07726299959 404.195495648127 0.990487665686323 -0.0137890852082093 0.967809723585026 1 4.08237 3.72286 4.00229 3.61223 GeneID:9760,Genbank:NM_014729.2,HGNC:HGNC:18988,MIM:606863 thymocyte selection associated high mobility group box GO:0003677,GO:0005634 DNA binding|nucleus TOX2 1.72545033768766 1.02816907859967 2.42273159677566 2.35635524078913 1.23655705423232 0.731221338003923 1 0.0160968 0.0139857 0.0296805 0.0417924 GeneID:84969,Genbank:NM_001098797.1,HGNC:HGNC:16095,MIM:611163 TOX high mobility group box family member 2 GO:0000978,GO:0001077,GO:0005654,GO:0045944 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleoplasm|positive regulation of transcription from RNA polymerase II promoter TOX3 146.029596099981 146.643968042273 145.41522415769 0.991620904009986 -0.0121394101976378 0.976870049089674 1 0.958802 0.985541 1.24632 0.743654 GeneID:27324,Genbank:XM_005255892.3,HGNC:HGNC:11972,MIM:611416 TOX high mobility group box family member 3 GO:0003682,GO:0005634,GO:0006351,GO:0006915,GO:0034056,GO:0042803,GO:0042981,GO:0043524,GO:0045893,GO:0051219 chromatin binding|nucleus|transcription, DNA-templated|apoptotic process|estrogen response element binding|protein homodimerization activity|regulation of apoptotic process|negative regulation of neuron apoptotic process|positive regulation of transcription, DNA-templated|phosphoprotein binding TOX4 1353.35490050758 1326.5028245287 1380.20697648646 1.04048551647589 0.0572568829455738 0.700697970551342 1 10.8949 11.4377 12.0892 11.6877 GeneID:9878,Genbank:NM_014828.3,HGNC:HGNC:20161,MIM:614032 TOX high mobility group box family member 4 GO:0000785,GO:0003677,GO:0005634,GO:0072357 chromatin|DNA binding|nucleus|PTW/PP1 phosphatase complex TP53 3049.31250718477 3171.10782912311 2927.51718524644 0.923184370572467 -0.115309295393206 0.392839460754468 1 29.8781 31.1328 29.0057 29.2389 GeneID:7157,Genbank:NM_001126112.2,HGNC:HGNC:11998,MIM:191170 tumor protein p53 hsa01522,hsa01524,hsa04010,hsa04071,hsa04110,hsa04115,hsa04137,hsa04151,hsa04210,hsa04211,hsa04216,hsa04218,hsa04310,hsa04722,hsa04919,hsa05014,hsa05016,hsa05160,hsa05161,hsa05162,hsa05163,hsa05165,hsa05166,hsa05167,hsa05168,hsa05169,hsa05200,hsa05202,hsa05203,hsa05205,hsa05206,hsa05210,hsa05212,hsa05213,hsa05214,hsa05215,hsa05216,hsa05217,hsa05218,hsa05219,hsa05220,hsa05222,hsa05223,hsa05224,hsa05225,hsa05226,hsa05230,hsa05418 Endocrine resistance|Platinum drug resistance|MAPK signaling pathway|Sphingolipid signaling pathway|Cell cycle|p53 signaling pathway|Mitophagy - animal|PI3K-Akt signaling pathway|Apoptosis|Longevity regulating pathway|Ferroptosis|Cellular senescence|Wnt signaling pathway|Neurotrophin signaling pathway|Thyroid hormone signaling pathway|Amyotrophic lateral sclerosis (ALS)|Huntington disease|Hepatitis C|Hepatitis B|Measles|Human cytomegalovirus infection|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Proteoglycans in cancer|MicroRNAs in cancer|Colorectal cancer|Pancreatic cancer|Endometrial cancer|Glioma|Prostate cancer|Thyroid cancer|Basal cell carcinoma|Melanoma|Bladder cancer|Chronic myeloid leukemia|Small cell lung cancer|Non-small cell lung cancer|Breast cancer|Hepatocellular carcinoma|Gastric cancer|Central carbon metabolism in cancer|Fluid shear stress and atherosclerosis TP53AIP1 2.72753971528646 2.54640955915669 2.90866987141623 1.14226317638373 0.191895084607054 1 1 0.011014 0.0149582 0.0207405 0.00968162 GeneID:63970,Genbank:XM_017018117.1,HGNC:HGNC:29984,MIM:605426 tumor protein p53 regulated apoptosis inducing protein 1 GO:0005739,GO:0005759,GO:0006915,GO:0042981 mitochondrion|mitochondrial matrix|apoptotic process|regulation of apoptotic process hsa04115,hsa04210 p53 signaling pathway|Apoptosis TP53BP1 2292.46407835122 2315.81320055053 2269.11495615192 0.979835055613506 -0.0293891869622047 0.836659938826622 1 5.9361 5.95901 6.40287 5.48679 GeneID:7158,Genbank:NM_005657.3,HGNC:HGNC:11999,MIM:605230 tumor protein p53 binding protein 1 hsa04621 NOD-like receptor signaling pathway TP53BP2 1016.72491223435 1030.65867022989 1002.79115423882 0.972961449996974 -0.0395454502098192 0.798237044247561 1 6.30529 6.36537 7.03671 5.44419 GeneID:7159,Genbank:NM_001031685.2,HGNC:HGNC:12000,MIM:602143 tumor protein p53 binding protein 2 hsa04390 Hippo signaling pathway TP53I11 13.2983406755317 13.5102768458505 13.0864045052128 0.96862593228296 -0.0459884672573284 1 1 0.0610427 0.0466652 0.106262 0.0597422 GeneID:9537,Genbank:NM_001258324.1,HGNC:HGNC:16842,MIM:617867 tumor protein p53 inducible protein 11 GO:0006950,GO:0008285,GO:0016021 response to stress|negative regulation of cell proliferation|integral component of membrane TP53I13 795.968102991578 719.114647759933 872.821558223222 1.21374465245854 0.279464939402617 0.0838843407913271 0.963076417285947 14.5377 16.5805 20.3329 19.7485 GeneID:90313,Genbank:XM_024451016.1,HGNC:HGNC:25102 tumor protein p53 inducible protein 13 GO:0005737,GO:0005886,GO:0009411,GO:0014070,GO:0016021,GO:0042493,GO:0045786 cytoplasm|plasma membrane|response to UV|response to organic cyclic compound|integral component of membrane|response to drug|negative regulation of cell cycle TP53I3 595.070660313663 544.661071319929 645.480249307398 1.18510443153784 0.245014195176994 0.144821584463077 1 6.58641 6.74353 7.58168 8.5912 GeneID:9540,Genbank:XM_005264650.3,HGNC:HGNC:19373,MIM:605171 tumor protein p53 inducible protein 3 hsa04115 p53 signaling pathway TP53INP1 199.363786480608 229.579670830943 169.147902130272 0.736772125850935 -0.44070961361191 0.0545303414803126 0.850412673568737 1.80526 1.84685 1.50738 1.25937 GeneID:94241,Genbank:NM_033285.3,HGNC:HGNC:18022,MIM:606185 tumor protein p53 inducible nuclear protein 1 hsa05166 Human T-cell leukemia virus 1 infection TP53INP2 1449.75650979776 1196.02038709505 1703.49263250046 1.42430066483898 0.510253726280106 0.000429504660252195 0.0573245553216597 13.7755 12.5001 19.6792 18.3727 GeneID:58476,Genbank:NM_021202.2,HGNC:HGNC:16104,MIM:617549 tumor protein p53 inducible nuclear protein 2 GO:0000045,GO:0001649,GO:0001894,GO:0005634,GO:0005776,GO:0005829,GO:0006351,GO:0006511,GO:0010508,GO:0016605,GO:0031410,GO:0043130,GO:0045893,GO:1903828 autophagosome assembly|osteoblast differentiation|tissue homeostasis|nucleus|autophagosome|cytosol|transcription, DNA-templated|ubiquitin-dependent protein catabolic process|positive regulation of autophagy|PML body|cytoplasmic vesicle|ubiquitin binding|positive regulation of transcription, DNA-templated|negative regulation of cellular protein localization hsa04140 Autophagy - animal TP53RK 652.812618265352 710.052214150421 595.573022380283 0.838773558495113 -0.253646712266925 0.123882735317472 1 9.80265 9.9851 8.00726 8.55357 GeneID:112858,Genbank:NM_033550.3,HGNC:HGNC:16197,MIM:608679 TP53 regulating kinase GO:0000408,GO:0002039,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006468,GO:0008033,GO:0016020,GO:0016787,GO:0070525,GO:1901796 EKC/KEOPS complex|p53 binding|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytosol|protein phosphorylation|tRNA processing|membrane|hydrolase activity|tRNA threonylcarbamoyladenosine metabolic process|regulation of signal transduction by p53 class mediator TP53TG5 0.974269732491135 0.980142803914724 0.968396661067546 0.988015886256305 -0.0173938558720137 1 1 0 0.0298881 0 0 GeneID:27296,Genbank:XM_011528790.2,HGNC:HGNC:15856,MIM:617316 TP53 target 5 GO:0005634,GO:0005737,GO:0030308,GO:0035556 nucleus|cytoplasm|negative regulation of cell growth|intracellular signal transduction TP63 6.94593525204898 7.59120240278514 6.30066810131283 0.829996062152311 -0.268823603158896 0.856437652325657 1 0.0293985 0.0440248 0.0335953 0.0313968 GeneID:8626,Genbank:NM_001329964.1,HGNC:HGNC:15979,MIM:603273 tumor protein p63 hsa05206 MicroRNAs in cancer TP73 541.210817534976 499.44124917176 582.980385898191 1.16726519258265 0.223132366152174 0.200370432174641 1 3.3986 3.44331 3.90622 4.15799 GeneID:7161,Genbank:NM_005427.3,HGNC:HGNC:12003,MIM:601990 tumor protein p73 GO:0000122,GO:0000187,GO:0000785,GO:0000978,GO:0000981,GO:0001077,GO:0001822,GO:0002039,GO:0003682,GO:0003684,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0005739,GO:0005794,GO:0005829,GO:0006298,GO:0006974,GO:0006978,GO:0007050,GO:0007346,GO:0008134,GO:0008285,GO:0008630,GO:0010165,GO:0010243,GO:0010332,GO:0010468,GO:0016032,GO:0019901,GO:0030054,GO:0031571,GO:0034644,GO:0042493,GO:0042771,GO:0042802,GO:0042981,GO:0043231,GO:0043508,GO:0043524,GO:0044212,GO:0045665,GO:0045893,GO:0045944,GO:0046872,GO:0048714,GO:0051262,GO:0060044,GO:0071158,GO:0097371,GO:1900740,GO:1901796,GO:1902036 negative regulation of transcription from RNA polymerase II promoter|activation of MAPK activity|chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|kidney development|p53 binding|chromatin binding|damaged DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|mitochondrion|Golgi apparatus|cytosol|mismatch repair|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|cell cycle arrest|regulation of mitotic cell cycle|transcription factor binding|negative regulation of cell proliferation|intrinsic apoptotic signaling pathway in response to DNA damage|response to X-ray|response to organonitrogen compound|response to gamma radiation|regulation of gene expression|viral process|protein kinase binding|cell junction|mitotic G1 DNA damage checkpoint|cellular response to UV|response to drug|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|identical protein binding|regulation of apoptotic process|intracellular membrane-bounded organelle|negative regulation of JUN kinase activity|negative regulation of neuron apoptotic process|transcription regulatory region DNA binding|negative regulation of neuron differentiation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|positive regulation of oligodendrocyte differentiation|protein tetramerization|negative regulation of cardiac muscle cell proliferation|positive regulation of cell cycle arrest|MDM2/MDM4 family protein binding|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of signal transduction by p53 class mediator|regulation of hematopoietic stem cell differentiation hsa04115,hsa04390,hsa04722,hsa05162 p53 signaling pathway|Hippo signaling pathway|Neurotrophin signaling pathway|Measles TPBG 1953.28345299457 1876.87124788273 2029.6956581064 1.08142508997145 0.112933733658936 0.422159460361174 1 28.1791 27.7276 32.6366 28.8014 GeneID:7162,Genbank:NM_006670.4,HGNC:HGNC:12004,MIM:190920 trophoblast glycoprotein GO:0005783,GO:0005887,GO:0007155,GO:0009986,GO:0051965 endoplasmic reticulum|integral component of plasma membrane|cell adhesion|cell surface|positive regulation of synapse assembly TPCN1 982.851152714115 949.904784113108 1015.79752131512 1.06936772853875 0.0967580447446058 0.540139880950494 1 5.76496 6.05326 6.7841 6.31052 GeneID:53373,Genbank:XM_011538490.2,HGNC:HGNC:18182,MIM:609666 two pore segment channel 1 GO:0005245,GO:0005764,GO:0005765,GO:0005768,GO:0005886,GO:0010008,GO:0010508,GO:0016021,GO:0034220,GO:0034765,GO:0042802,GO:0072345,GO:0086010 voltage-gated calcium channel activity|lysosome|lysosomal membrane|endosome|plasma membrane|endosome membrane|positive regulation of autophagy|integral component of membrane|ion transmembrane transport|regulation of ion transmembrane transport|identical protein binding|NAADP-sensitive calcium-release channel activity|membrane depolarization during action potential TPCN2 609.848002502403 597.425086597054 622.270918407752 1.04158819635818 0.0587850045839147 0.747981814660977 1 3.12457 3.47101 3.411 3.27839 GeneID:219931,Genbank:XM_017017333.2,HGNC:HGNC:20820,MIM:612163 two pore segment channel 2 GO:0005245,GO:0005764,GO:0005765,GO:0005886,GO:0006874,GO:0006939,GO:0007040,GO:0010008,GO:0010506,GO:0016021,GO:0019722,GO:0019901,GO:0033280,GO:0034220,GO:0034765,GO:0042802,GO:0072345,GO:0086010 voltage-gated calcium channel activity|lysosome|lysosomal membrane|plasma membrane|cellular calcium ion homeostasis|smooth muscle contraction|lysosome organization|endosome membrane|regulation of autophagy|integral component of membrane|calcium-mediated signaling|protein kinase binding|response to vitamin D|ion transmembrane transport|regulation of ion transmembrane transport|identical protein binding|NAADP-sensitive calcium-release channel activity|membrane depolarization during action potential hsa04972 Pancreatic secretion TPD52 974.405299809255 1016.82201811635 931.988581502163 0.916570023954302 -0.125682991151618 0.408301718883779 1 7.83643 8.30648 8.08471 6.789 GeneID:7163,Genbank:NM_001287144.1,HGNC:HGNC:12005,MIM:604068 tumor protein D52 GO:0005509,GO:0005737,GO:0005783,GO:0030183,GO:0042803,GO:0046982,GO:0048471 calcium ion binding|cytoplasm|endoplasmic reticulum|B cell differentiation|protein homodimerization activity|protein heterodimerization activity|perinuclear region of cytoplasm TPD52L1 103.155981812174 94.3612325128525 111.950731111496 1.18640598612621 0.246597782180985 0.424084520538139 1 0.882878 0.75193 1.08041 0.982284 GeneID:7164,Genbank:NM_001318903.1,HGNC:HGNC:12006,MIM:604069 tumor protein D52 like 1 GO:0000086,GO:0005737,GO:0042802,GO:0042803,GO:0043406,GO:0046330,GO:0046982,GO:0048471,GO:2001235 G2/M transition of mitotic cell cycle|cytoplasm|identical protein binding|protein homodimerization activity|positive regulation of MAP kinase activity|positive regulation of JNK cascade|protein heterodimerization activity|perinuclear region of cytoplasm|positive regulation of apoptotic signaling pathway TPD52L2 3875.3049877494 3883.35268560138 3867.25728989741 0.995855283563696 -0.00599198798979119 0.949966801732841 1 50.0898 53.9697 52.4821 52.5914 GeneID:7165,Genbank:NM_199360.2,HGNC:HGNC:12007,MIM:603747 tumor protein D52 like 2 GO:0003723,GO:0005737,GO:0042127,GO:0042803,GO:0046982,GO:0048471 RNA binding|cytoplasm|regulation of cell proliferation|protein homodimerization activity|protein heterodimerization activity|perinuclear region of cytoplasm TPGS1 353.249497736763 355.151585589904 351.347409883621 0.989288585886602 -0.0155366631891448 0.919621835244669 1 30.2621 31.2689 31.0696 31.2845 GeneID:91978,Genbank:NM_033513.2,HGNC:HGNC:25058 tubulin polyglutamylase complex subunit 1 GO:0005737,GO:0005813,GO:0005874,GO:0007268,GO:0007275,GO:0007288,GO:0008017,GO:0018095,GO:0030424,GO:0030425,GO:0030534,GO:0031514,GO:0051648,GO:0070740 cytoplasm|centrosome|microtubule|chemical synaptic transmission|multicellular organism development|sperm axoneme assembly|microtubule binding|protein polyglutamylation|axon|dendrite|adult behavior|motile cilium|vesicle localization|tubulin-glutamic acid ligase activity TPGS2 2421.87100572114 2363.9068245264 2479.83518691588 1.04904100330296 0.069071068864403 0.617995580218521 1 6.2769 6.141 7.09271 6.65644 GeneID:25941,Genbank:XM_017025702.2,HGNC:HGNC:24561 tubulin polyglutamylase complex subunit 2 GO:0005737,GO:0005874 cytoplasm|microtubule TPH1 1.74989846105683 1.07619535328461 2.42360156882906 2.25200895119282 1.17121256179462 0.729411591636508 1 0.0210044 0 0.0606164 0.0187917 GeneID:7166,Genbank:NM_004179.2,HGNC:HGNC:12008,MIM:191060 tryptophan hydroxylase 1 GO:0004510,GO:0005506,GO:0005829,GO:0007623,GO:0009072,GO:0030279,GO:0035902,GO:0042427,GO:0043005,GO:0045600,GO:0046219,GO:0046849,GO:0060749 tryptophan 5-monooxygenase activity|iron ion binding|cytosol|circadian rhythm|aromatic amino acid family metabolic process|negative regulation of ossification|response to immobilization stress|serotonin biosynthetic process|neuron projection|positive regulation of fat cell differentiation|indolalkylamine biosynthetic process|bone remodeling|mammary gland alveolus development hsa00380,hsa00790,hsa04726 Tryptophan metabolism|Folate biosynthesis|Serotonergic synapse TPI1 26171.0378320718 25813.3790458721 26528.6966182714 1.02771111721283 0.0394347894981584 0.789852032519858 1 463.227 484.377 471.127 527.945 GeneID:7167,Genbank:NM_001159287.1,HGNC:HGNC:12009,MIM:190450 triosephosphate isomerase 1 hsa00010,hsa00051,hsa00562 Glycolysis / Gluconeogenesis|Fructose and mannose metabolism|Inositol phosphate metabolism TPK1 85.4965008578307 91.5070479953703 79.4859537202911 0.868632039406545 -0.203182927450775 0.539498901552409 1 0.200815 0.212487 0.193511 0.124255 GeneID:27010,Genbank:XM_011516033.2,HGNC:HGNC:17358,MIM:606370 thiamin pyrophosphokinase 1 GO:0004788,GO:0005524,GO:0005829,GO:0006772,GO:0009229,GO:0016301,GO:0030975,GO:0042723 thiamine diphosphokinase activity|ATP binding|cytosol|thiamine metabolic process|thiamine diphosphate biosynthetic process|kinase activity|thiamine binding|thiamine-containing compound metabolic process hsa00730 Thiamine metabolism TPM1 3640.07791434521 3834.95804431973 3445.19778437068 0.898366486557432 -0.154623985692063 0.253429481867433 1 15.4999 15.9062 15.331 14.6038 GeneID:7168,Genbank:NM_001018020.1,HGNC:HGNC:12010,MIM:191010 tropomyosin 1 GO:0001725,GO:0002102,GO:0005737,GO:0005862,GO:0005884,GO:0005903,GO:0006936,GO:0007015,GO:0007420,GO:0008307,GO:0030426,GO:0030863,GO:0043005,GO:0051015,GO:0070062 stress fiber|podosome|cytoplasm|muscle thin filament tropomyosin|actin filament|brush border|muscle contraction|actin filament organization|brain development|structural constituent of muscle|growth cone|cortical cytoskeleton|neuron projection|actin filament binding|extracellular exosome hsa04260,hsa04261,hsa05206,hsa05410,hsa05414 Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|MicroRNAs in cancer|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) TPM2 107.954328941805 110.754102840654 105.154555042955 0.949441621988887 -0.0748487983107277 0.808745059035345 1 1.08796 1.06959 0.823129 1.09863 GeneID:7169,Genbank:NM_001301226.1,HGNC:HGNC:12011,MIM:190990 tropomyosin 2 GO:0005862,GO:0005884,GO:0006936,GO:0007015,GO:0008307,GO:0015629,GO:0042802,GO:0042803,GO:0046982,GO:0051015 muscle thin filament tropomyosin|actin filament|muscle contraction|actin filament organization|structural constituent of muscle|actin cytoskeleton|identical protein binding|protein homodimerization activity|protein heterodimerization activity|actin filament binding hsa04260,hsa04261,hsa05410,hsa05414 Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) TPM3 13182.268422067 13116.7513839054 13247.7854602286 1.0099898269387 0.0143407615919237 0.916494431283459 1 34.7505 36.6359 36.4485 37.4844 GeneID:7170,Genbank:NM_001278188.1,HGNC:HGNC:12012,MIM:191030 tropomyosin 3 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding hsa04260,hsa04261,hsa05200,hsa05216,hsa05410,hsa05414 Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Pathways in cancer|Thyroid cancer|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) TPM4 14897.2315617382 9853.61192441536 19940.8511990611 2.0237098184932 1.01700243556868 6.17019940432757e-15 3.29406378865701e-11 56.9472 55.6088 121.897 111.484 GeneID:7171,Genbank:NM_001145160.1,HGNC:HGNC:12013,MIM:600317 tropomyosin 4 GO:0016021 integral component of membrane hsa04260,hsa04261,hsa05410,hsa05414 Cardiac muscle contraction|Adrenergic signaling in cardiomyocytes|Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) TPMT 1740.62423749271 1932.90984149269 1548.33863349273 0.801040276300226 -0.320053311731802 0.0261798712508575 0.647062990669342 18.075 17.0735 14.5496 14.3498 GeneID:7172,Genbank:NM_001346818.1,HGNC:HGNC:12014,MIM:187680 thiopurine S-methyltransferase GO:0005829,GO:0006139,GO:0008119,GO:0032259,GO:0070062 cytosol|nucleobase-containing compound metabolic process|thiopurine S-methyltransferase activity|methylation|extracellular exosome hsa00983 Drug metabolism - other enzymes TPO 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0100283 0 0 GeneID:7173,Genbank:XM_024453089.1,HGNC:HGNC:12015,MIM:606765 thyroid peroxidase hsa00350,hsa04918,hsa05320 Tyrosine metabolism|Thyroid hormone synthesis|Autoimmune thyroid disease TPP1 1563.81019192925 1394.10223503263 1733.51814882587 1.24346558327216 0.314366577092639 0.0289386226064552 0.674846840672015 16.8323 16.4773 21.6325 20.5128 GeneID:1200,Genbank:NM_000391.3,HGNC:HGNC:2073,MIM:607998 tripeptidyl peptidase 1 hsa04142 Lysosome TPP2 458.838870840868 504.71534773285 412.962393948886 0.818208512588109 -0.28945954787802 0.233221003407403 1 2.93047 2.72574 2.77535 1.96153 GeneID:7174,Genbank:NM_001330588.1,HGNC:HGNC:12016,MIM:190470 tripeptidyl peptidase 2 GO:0000209,GO:0004175,GO:0004177,GO:0004252,GO:0005654,GO:0005737,GO:0005829,GO:0006508,GO:0008240,GO:0016604,GO:0042802 protein polyubiquitination|endopeptidase activity|aminopeptidase activity|serine-type endopeptidase activity|nucleoplasm|cytoplasm|cytosol|proteolysis|tripeptidyl-peptidase activity|nuclear body|identical protein binding TPPP 18.3913411197468 14.4904196497652 22.2922625897283 1.53841387127042 0.621443676060616 0.351352004109585 1 0.0720984 0.0493269 0.105111 0.0985265 GeneID:11076,Genbank:XM_024454346.1,HGNC:HGNC:24164,MIM:608773 tubulin polymerization promoting protein GO:0001578,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005874,GO:0008017,GO:0015631,GO:0031334,GO:0032273,GO:0043209,GO:0046785,GO:0048471 microtubule bundle formation|nucleus|cytoplasm|mitochondrion|cytosol|microtubule|microtubule binding|tubulin binding|positive regulation of protein complex assembly|positive regulation of protein polymerization|myelin sheath|microtubule polymerization|perinuclear region of cytoplasm TPPP3 10.9870930060684 11.7999312665537 10.174254745583 0.862230000815464 -0.213855333722503 0.856051985650447 1 0.173144 0.187266 0.120702 0.131249 GeneID:51673,Genbank:NM_015964.3,HGNC:HGNC:24162,MIM:616957 tubulin polymerization promoting protein family member 3 GO:0001578,GO:0005737,GO:0005874,GO:0015631,GO:0046785,GO:0070062 microtubule bundle formation|cytoplasm|microtubule|tubulin binding|microtubule polymerization|extracellular exosome TPR 339.217334749498 345.897046881652 332.537622617343 0.961377454983359 -0.0568251232870232 0.898965137022719 1 0.986482 0.883788 1.1542 0.629498 GeneID:7175,Genbank:NM_003292.2,HGNC:HGNC:12017,MIM:189940 translocated promoter region, nuclear basket protein hsa03013,hsa05200,hsa05216 RNA transport|Pathways in cancer|Thyroid cancer TPRA1 480.463162049745 480.204002981584 480.722321117905 1.00107937071141 0.00155636297734901 0.993774130295445 1 2.77204 3.06035 2.80408 3.22565 GeneID:131601,Genbank:NM_001353005.1,HGNC:HGNC:30413,MIM:608336 transmembrane protein adipocyte associated 1 GO:0004930,GO:0006629,GO:0007568,GO:0016021,GO:0040016,GO:1901991 G-protein coupled receptor activity|lipid metabolic process|aging|integral component of membrane|embryonic cleavage|negative regulation of mitotic cell cycle phase transition TPRG1 45.2731189990021 30.9411249073599 59.6051130906443 1.92640420376139 0.94591044543445 0.0256129666779481 0.636983345208101 0.0607111 0.0371739 0.0905056 0.0743602 GeneID:285386,Genbank:XM_017006261.2,HGNC:HGNC:24759 tumor protein p63 regulated 1 GO:0005737 cytoplasm TPRG1L 644.176378327082 853.737153471588 434.615603182575 0.509074252438563 -0.974051994947685 0.000195893261123977 0.0352519828108047 16.4836 17.401 6.60912 10.5361 GeneID:127262,Genbank:NM_182752.3,HGNC:HGNC:27007,MIM:611460 tumor protein p63 regulated 1 like GO:0008021,GO:0030054,GO:0030672,GO:0042802,GO:0070062 synaptic vesicle|cell junction|synaptic vesicle membrane|identical protein binding|extracellular exosome TPRKB 389.058629533968 410.307105946168 367.810153121769 0.896426476147907 -0.157742835102863 0.397751005392924 1 6.68805 6.71977 6.16186 5.64499 GeneID:51002,Genbank:NM_001330391.1,HGNC:HGNC:24259,MIM:608680 TP53RK binding protein GO:0000408,GO:0005634,GO:0005829,GO:0008033,GO:0019901 EKC/KEOPS complex|nucleus|cytosol|tRNA processing|protein kinase binding TPRN 405.508121087304 402.485580825066 408.530661349543 1.01501937165571 0.021507261523694 0.924919764551943 1 7.41998 7.22524 7.29203 7.4453 GeneID:286262,Genbank:NM_001128228.2,HGNC:HGNC:26894,MIM:613354 taperin GO:0007605,GO:0019902,GO:0032420 sensory perception of sound|phosphatase binding|stereocilium TPRX1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:284355,Genbank:NM_198479.2,HGNC:HGNC:32174,MIM:611166 tetrapeptide repeat homeobox 1 GO:0003677,GO:0005634 DNA binding|nucleus TPSG1 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0320469 0 0 GeneID:25823,Genbank:NM_012467.3,HGNC:HGNC:14134,MIM:609341 tryptase gamma 1 GO:0004252,GO:0005887,GO:0008236 serine-type endopeptidase activity|integral component of plasma membrane|serine-type peptidase activity TPST1 1195.3693796842 1203.90178114766 1186.83697822075 0.985825419320638 -0.0205959137818208 0.872717998675493 1 8.22452 9.47317 9.05125 8.69235 GeneID:8460,Genbank:NM_003596.3,HGNC:HGNC:12020,MIM:603125 tyrosylprotein sulfotransferase 1 GO:0000139,GO:0005794,GO:0006478,GO:0006954,GO:0008476,GO:0016020,GO:0030173,GO:0042803,GO:0050427 Golgi membrane|Golgi apparatus|peptidyl-tyrosine sulfation|inflammatory response|protein-tyrosine sulfotransferase activity|membrane|integral component of Golgi membrane|protein homodimerization activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process TPST2 327.835366177339 362.473230653941 293.197501700738 0.8088804273126 -0.30600164275488 0.115479937905 1 3.615 3.71112 3.24081 3.03168 GeneID:8459,Genbank:XM_024452294.1,HGNC:HGNC:12021,MIM:603126 tyrosylprotein sulfotransferase 2 GO:0000139,GO:0005783,GO:0005794,GO:0006478,GO:0008476,GO:0016021,GO:0042803,GO:0050427,GO:0070062 Golgi membrane|endoplasmic reticulum|Golgi apparatus|peptidyl-tyrosine sulfation|protein-tyrosine sulfotransferase activity|integral component of membrane|protein homodimerization activity|3'-phosphoadenosine 5'-phosphosulfate metabolic process|extracellular exosome TPT1 20582.0225085149 21687.8211584959 19476.223858534 0.89802584207056 -0.155171133561684 0.358033876654259 1 106.857 114.198 93.9202 110.874 GeneID:7178,Genbank:NM_001286273.1,HGNC:HGNC:12022,MIM:600763 tumor protein, translationally-controlled 1 GO:0003723,GO:0005509,GO:0005615,GO:0005634,GO:0005737,GO:0005771,GO:0005829,GO:0006816,GO:0006874,GO:0008017,GO:0009615,GO:0030154,GO:0042981,GO:0043066,GO:0070062,GO:1902230 RNA binding|calcium ion binding|extracellular space|nucleus|cytoplasm|multivesicular body|cytosol|calcium ion transport|cellular calcium ion homeostasis|microtubule binding|response to virus|cell differentiation|regulation of apoptotic process|negative regulation of apoptotic process|extracellular exosome|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage TPTE2 0.998282869833606 1.02816907859967 0.968396661067546 0.941865186596032 -0.0864075197076174 1 1 0.0163938 0.0159468 0 0 GeneID:93492,Genbank:NM_130785.3,HGNC:HGNC:17299,MIM:606791 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 GO:0000139,GO:0004725,GO:0005789,GO:0006661,GO:0008138,GO:0016021,GO:0016314,GO:0051800 Golgi membrane|protein tyrosine phosphatase activity|endoplasmic reticulum membrane|phosphatidylinositol biosynthetic process|protein tyrosine/serine/threonine phosphatase activity|integral component of membrane|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity TPX2 8399.53658285815 8284.03099486669 8515.04217084962 1.02788632443868 0.0396807234454921 0.757294380499182 1 65.7139 66.8118 71.001 65.7127 GeneID:22974,Genbank:NM_012112.4,HGNC:HGNC:1249,MIM:605917 TPX2, microtubule nucleation factor GO:0000278,GO:0000922,GO:0005524,GO:0005525,GO:0005634,GO:0005654,GO:0005815,GO:0005819,GO:0005829,GO:0005874,GO:0006915,GO:0008283,GO:0010389,GO:0015630,GO:0019901,GO:0032147,GO:0043203,GO:0045171,GO:0051301,GO:0060236,GO:0061676,GO:0072686,GO:0090307,GO:1901796 mitotic cell cycle|spindle pole|ATP binding|GTP binding|nucleus|nucleoplasm|microtubule organizing center|spindle|cytosol|microtubule|apoptotic process|cell proliferation|regulation of G2/M transition of mitotic cell cycle|microtubule cytoskeleton|protein kinase binding|activation of protein kinase activity|axon hillock|intercellular bridge|cell division|regulation of mitotic spindle organization|importin-alpha family protein binding|mitotic spindle|mitotic spindle assembly|regulation of signal transduction by p53 class mediator TRA2A 910.500017310575 998.5246631088 822.475371512351 0.823690592630593 -0.279825583091883 0.0760457199745817 0.94157495521624 13.1076 12.0573 11.2726 9.16969 GeneID:29896,Genbank:NM_013293.4,HGNC:HGNC:16645,MIM:602718 transformer 2 alpha homolog GO:0000398,GO:0003723,GO:0005634,GO:0005730,GO:0043231 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleolus|intracellular membrane-bounded organelle hsa03040 Spliceosome TRA2B 4266.52270569056 4539.193994229 3993.85141715212 0.879859160509507 -0.184655485564547 0.174078820577135 1 28.7898 28.2 26.3283 23.9618 GeneID:6434,Genbank:NM_001243879.1,HGNC:HGNC:10781,MIM:602719 transformer 2 beta homolog GO:0000302,GO:0000381,GO:0000398,GO:0003723,GO:0003729,GO:0005634,GO:0005637,GO:0005654,GO:0005681,GO:0019904,GO:0021796,GO:0036002,GO:0042802,GO:0043484,GO:0048025,GO:0048026,GO:0048471,GO:0051259,GO:0070717,GO:0071333,GO:1990403 response to reactive oxygen species|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleus|nuclear inner membrane|nucleoplasm|spliceosomal complex|protein domain specific binding|cerebral cortex regionalization|pre-mRNA binding|identical protein binding|regulation of RNA splicing|negative regulation of mRNA splicing, via spliceosome|positive regulation of mRNA splicing, via spliceosome|perinuclear region of cytoplasm|protein oligomerization|poly-purine tract binding|cellular response to glucose stimulus|embryonic brain development hsa03040 Spliceosome TRABD 792.159379519677 776.451984788089 807.866774251265 1.04045941034171 0.0572206847840259 0.746221773087266 1 11.9673 12.897 13.3061 13.4281 GeneID:80305,Genbank:XM_011530716.2,HGNC:HGNC:28805 TraB domain containing TRABD2A 11.6005028446603 12.5399426970437 10.661062992277 0.850168397881939 -0.234179462193931 0.794992601194747 1 0.018176 0.15288 0.0863932 0.0966731 GeneID:129293,Genbank:XM_011532504.1,HGNC:HGNC:27013,MIM:614912 TraB domain containing 2A GO:0004175,GO:0004222,GO:0005887,GO:0006508,GO:0016055,GO:0017147,GO:0030178,GO:0031301,GO:0032461,GO:0046872,GO:0060322,GO:1904808 endopeptidase activity|metalloendopeptidase activity|integral component of plasma membrane|proteolysis|Wnt signaling pathway|Wnt-protein binding|negative regulation of Wnt signaling pathway|integral component of organelle membrane|positive regulation of protein oligomerization|metal ion binding|head development|positive regulation of protein oxidation TRABD2B 2.45762090491191 2.00831188251439 2.90692992730943 1.44744944877286 0.533512963911774 0.908782745802202 1 0.00340489 0.00612613 0.00319693 0.0089748 GeneID:388630,Genbank:XM_024446933.1,HGNC:HGNC:44200,MIM:614913 TraB domain containing 2B GO:0004222,GO:0005887,GO:0006508,GO:0016055,GO:0017147,GO:0030178,GO:0031301,GO:0032461,GO:0046872,GO:0070062,GO:1904808 metalloendopeptidase activity|integral component of plasma membrane|proteolysis|Wnt signaling pathway|Wnt-protein binding|negative regulation of Wnt signaling pathway|integral component of organelle membrane|positive regulation of protein oligomerization|metal ion binding|extracellular exosome|positive regulation of protein oxidation TRADD 532.081817949623 476.341266695718 587.822369203529 1.23403620534734 0.303384722290264 0.0830959439623906 0.963076417285947 10.4199 12.5231 14.1223 14.8994 GeneID:8717,Genbank:NM_003789.3,HGNC:HGNC:12030,MIM:603500 TNFRSF1A associated via death domain hsa04010,hsa04064,hsa04071,hsa04210,hsa04217,hsa04622,hsa04657,hsa04668,hsa04920,hsa05152,hsa05160,hsa05163,hsa05165,hsa05167,hsa05169,hsa05170,hsa05203 MAPK signaling pathway|NF-kappa B signaling pathway|Sphingolipid signaling pathway|Apoptosis|Necroptosis|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Tuberculosis|Hepatitis C|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Viral carcinogenesis TRAF1 189.998996682362 236.546531662824 143.4514617019 0.606440773802496 -0.721561339094214 0.00184133277496076 0.153441233527396 1.59224 1.66275 1.01421 0.948762 GeneID:7185,Genbank:NM_001190945.1,HGNC:HGNC:12031,MIM:601711 TNF receptor associated factor 1 GO:0005164,GO:0005737,GO:0005829,GO:0006461,GO:0006915,GO:0007165,GO:0008270,GO:0010803,GO:0031625,GO:0031996,GO:0042802,GO:0051092,GO:2001236 tumor necrosis factor receptor binding|cytoplasm|cytosol|protein complex assembly|apoptotic process|signal transduction|zinc ion binding|regulation of tumor necrosis factor-mediated signaling pathway|ubiquitin protein ligase binding|thioesterase binding|identical protein binding|positive regulation of NF-kappaB transcription factor activity|regulation of extrinsic apoptotic signaling pathway hsa04064,hsa04210,hsa04668,hsa05168,hsa05200,hsa05202,hsa05203,hsa05222 NF-kappa B signaling pathway|Apoptosis|TNF signaling pathway|Herpes simplex infection|Pathways in cancer|Transcriptional misregulation in cancer|Viral carcinogenesis|Small cell lung cancer TRAF2 794.886360830937 799.811715947772 789.961005714102 0.987683713507501 -0.0178789741379584 0.88674725838117 1 9.81557 10.819 10.935 9.9738 GeneID:7186,Genbank:XM_011518976.3,HGNC:HGNC:12032,MIM:601895 TNF receptor associated factor 2 hsa04010,hsa04064,hsa04071,hsa04141,hsa04210,hsa04217,hsa04380,hsa04621,hsa04622,hsa04657,hsa04668,hsa04920,hsa04932,hsa05160,hsa05163,hsa05167,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05222 MAPK signaling pathway|NF-kappa B signaling pathway|Sphingolipid signaling pathway|Protein processing in endoplasmic reticulum|Apoptosis|Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Adipocytokine signaling pathway|Non-alcoholic fatty liver disease (NAFLD)|Hepatitis C|Human cytomegalovirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer TRAF3 1160.74676122317 1058.98675899404 1262.5067634523 1.19218371025865 0.253606565881851 0.0921249220762575 0.985009977016794 4.26157 4.44776 5.58734 4.82217 GeneID:7187,Genbank:NM_145725.2,HGNC:HGNC:12033,MIM:601896 TNF receptor associated factor 3 hsa04064,hsa04620,hsa04621,hsa04622,hsa04657,hsa04668,hsa05160,hsa05165,hsa05167,hsa05168,hsa05169,hsa05200,hsa05203,hsa05222 NF-kappa B signaling pathway|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Hepatitis C|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer TRAF3IP1 282.071614131047 309.219143974859 254.924084287235 0.824412360147927 -0.27856195998782 0.18313474002273 1 1.99982 1.75168 1.73007 1.49209 GeneID:26146,Genbank:XM_011510944.2,HGNC:HGNC:17861,MIM:607380 TRAF3 interacting protein 1 GO:0001738,GO:0001822,GO:0001933,GO:0005813,GO:0005929,GO:0005930,GO:0008017,GO:0021532,GO:0030992,GO:0031076,GO:0031333,GO:0032480,GO:0032688,GO:0035050,GO:0035735,GO:0035869,GO:0036064,GO:0036342,GO:0042073,GO:0042733,GO:0050687,GO:0060271,GO:0070507,GO:0097542,GO:0097546,GO:1901621 morphogenesis of a polarized epithelium|kidney development|negative regulation of protein phosphorylation|centrosome|cilium|axoneme|microtubule binding|neural tube patterning|intraciliary transport particle B|embryonic camera-type eye development|negative regulation of protein complex assembly|negative regulation of type I interferon production|negative regulation of interferon-beta production|embryonic heart tube development|intraciliary transport involved in cilium assembly|ciliary transition zone|ciliary basal body|post-anal tail morphogenesis|intraciliary transport|embryonic digit morphogenesis|negative regulation of defense response to virus|cilium assembly|regulation of microtubule cytoskeleton organization|ciliary tip|ciliary base|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning TRAF3IP2 552.733452272689 544.748332215046 560.718572330332 1.02931673062742 0.0416869816439124 0.837465432231394 1 2.3016 2.79031 2.71175 2.61666 GeneID:10758,Genbank:NM_001164281.2,HGNC:HGNC:1343,MIM:607043 TRAF3 interacting protein 2 GO:0001783,GO:0002230,GO:0005102,GO:0005622,GO:0006959,GO:0035556,GO:0043123,GO:0048305 B cell apoptotic process|positive regulation of defense response to virus by host|receptor binding|intracellular|humoral immune response|intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB signaling|immunoglobulin secretion hsa04218,hsa04657 Cellular senescence|IL-17 signaling pathway TRAF3IP3 1.24125200715389 1.02816907859967 1.45433493570811 1.4144900541931 0.500282032643154 1 1 0.009902 0 0.00936335 0.00873435 GeneID:80342,Genbank:NM_025228.3,HGNC:HGNC:30766,MIM:608255 TRAF3 interacting protein 3 GO:0016021 integral component of membrane TRAF4 2367.88224963317 2404.92096881336 2330.84353045297 0.969197558123108 -0.0451373249393334 0.791917516086514 1 18.6915 20.275 17.6933 20.8306 GeneID:9618,Genbank:XM_011525504.3,HGNC:HGNC:12034,MIM:602464 TNF receptor associated factor 4 hsa04657,hsa05200,hsa05222 IL-17 signaling pathway|Pathways in cancer|Small cell lung cancer TRAF5 118.982910797246 120.189920991683 117.775900602809 0.979914951528743 -0.0292715541617519 0.955834767223163 1 0.608652 0.448353 0.619095 0.470933 GeneID:7188,Genbank:XM_011509960.3,HGNC:HGNC:12035,MIM:602356 TNF receptor associated factor 5 GO:0005164,GO:0005813,GO:0005829,GO:0006915,GO:0007165,GO:0008270,GO:0009898,GO:0031625,GO:0031996,GO:0035631,GO:0042802,GO:0042981,GO:0043123,GO:0051091,GO:0051092 tumor necrosis factor receptor binding|centrosome|cytosol|apoptotic process|signal transduction|zinc ion binding|cytoplasmic side of plasma membrane|ubiquitin protein ligase binding|thioesterase binding|CD40 receptor complex|identical protein binding|regulation of apoptotic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity hsa04064,hsa04217,hsa04621,hsa04657,hsa04668,hsa05163,hsa05168,hsa05169,hsa05170,hsa05200,hsa05203,hsa05222 NF-kappa B signaling pathway|Necroptosis|NOD-like receptor signaling pathway|IL-17 signaling pathway|TNF signaling pathway|Human cytomegalovirus infection|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Viral carcinogenesis|Small cell lung cancer TRAF6 358.011103583783 339.401657142368 376.620550025197 1.10966031573387 0.15011811278603 0.587520375571996 1 1.43609 1.39622 1.9503 1.30474 GeneID:7189,Genbank:NM_004620.3,HGNC:HGNC:12036,MIM:602355 TNF receptor associated factor 6 hsa04010,hsa04064,hsa04120,hsa04140,hsa04144,hsa04380,hsa04620,hsa04621,hsa04622,hsa04657,hsa04722,hsa05133,hsa05140,hsa05142,hsa05145,hsa05152,hsa05160,hsa05162,hsa05168,hsa05169,hsa05170,hsa05200,hsa05222 MAPK signaling pathway|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Autophagy - animal|Endocytosis|Osteoclast differentiation|Toll-like receptor signaling pathway|NOD-like receptor signaling pathway|RIG-I-like receptor signaling pathway|IL-17 signaling pathway|Neurotrophin signaling pathway|Pertussis|Leishmaniasis|Chagas disease (American trypanosomiasis)|Toxoplasmosis|Tuberculosis|Hepatitis C|Measles|Herpes simplex infection|Epstein-Barr virus infection|Human immunodeficiency virus 1 infection|Pathways in cancer|Small cell lung cancer TRAF7 2569.4138341273 2402.20207146568 2736.62559678892 1.13921540127521 0.188040555624442 0.183359301171807 1 20.6316 21.7007 24.5197 24.8978 GeneID:84231,Genbank:XM_011522700.1,HGNC:HGNC:20456,MIM:606692 TNF receptor associated factor 7 GO:0000151,GO:0000185,GO:0004842,GO:0005886,GO:0006351,GO:0006355,GO:0006915,GO:0008270,GO:0016567,GO:0031410,GO:0043231,GO:0043410,GO:2001235 ubiquitin ligase complex|activation of MAPKKK activity|ubiquitin-protein transferase activity|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|zinc ion binding|protein ubiquitination|cytoplasmic vesicle|intracellular membrane-bounded organelle|positive regulation of MAPK cascade|positive regulation of apoptotic signaling pathway TRAFD1 716.484994554741 706.49725282288 726.472736286601 1.02827397188582 0.04022470540762 0.816382453384827 1 7.82637 8.07561 8.8808 8.01147 GeneID:10906,Genbank:NM_001143906.1,HGNC:HGNC:24808,MIM:613197 TRAF-type zinc finger domain containing 1 GO:0034097,GO:0045824,GO:0046872 response to cytokine|negative regulation of innate immune response|metal ion binding TRAIP 588.061256849176 547.092828020355 629.029685677997 1.14976774225707 0.201342460356497 0.243237076460724 1 6.5219 7.01591 7.9032 8.15568 GeneID:10293,Genbank:XM_017005526.1,HGNC:HGNC:30764,MIM:605958 TRAF interacting protein GO:0005057,GO:0005730,GO:0006915,GO:0007165,GO:0008283,GO:0010804,GO:0032688,GO:0046872,GO:0048471,GO:0061630 signal transducer activity, downstream of receptor|nucleolus|apoptotic process|signal transduction|cell proliferation|negative regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of interferon-beta production|metal ion binding|perinuclear region of cytoplasm|ubiquitin protein ligase activity TRAK1 1681.94646922488 1716.59254148077 1647.30039696899 0.959633900976869 -0.0594439702830046 0.675281588826968 1 4.9365 5.11876 5.24824 4.63253 GeneID:22906,Genbank:XM_024453401.1,HGNC:HGNC:29947,MIM:608112 trafficking kinesin protein 1 GO:0005634,GO:0005737,GO:0005739,GO:0005769,GO:0006357,GO:0006493,GO:0006605,GO:0008333,GO:0030425,GO:0030911,GO:0044295,GO:0048471,GO:0048813,GO:0050772,GO:0050811,GO:0098957,GO:1904115 nucleus|cytoplasm|mitochondrion|early endosome|regulation of transcription from RNA polymerase II promoter|protein O-linked glycosylation|protein targeting|endosome to lysosome transport|dendrite|TPR domain binding|axonal growth cone|perinuclear region of cytoplasm|dendrite morphogenesis|positive regulation of axonogenesis|GABA receptor binding|anterograde axonal transport of mitochondrion|axon cytoplasm TRAK2 1872.39611327593 1962.71591911612 1782.07630743574 0.907964463975141 -0.13929226064219 0.344498979933851 1 11.2801 10.0722 10.5908 8.99284 GeneID:66008,Genbank:NM_015049.2,HGNC:HGNC:13206,MIM:607334 trafficking kinesin protein 2 GO:0005102,GO:0005634,GO:0005737,GO:0005739,GO:0005769,GO:0005886,GO:0006357,GO:0006493,GO:0006605,GO:0008333,GO:0019894,GO:0019899,GO:0030911,GO:0032839,GO:0043025,GO:0044295,GO:0048813,GO:0050771,GO:0050811,GO:0098972 receptor binding|nucleus|cytoplasm|mitochondrion|early endosome|plasma membrane|regulation of transcription from RNA polymerase II promoter|protein O-linked glycosylation|protein targeting|endosome to lysosome transport|kinesin binding|enzyme binding|TPR domain binding|dendrite cytoplasm|neuronal cell body|axonal growth cone|dendrite morphogenesis|negative regulation of axonogenesis|GABA receptor binding|anterograde dendritic transport of mitochondrion hsa04727 GABAergic synapse TRAM1 3530.5975246476 3793.57625614294 3267.61879315226 0.861355768942565 -0.215318852530685 0.200158829625143 1 46.4949 41.5486 42.1534 33.9884 GeneID:23471,Genbank:NM_001317804.1,HGNC:HGNC:20568,MIM:605190 translocation associated membrane protein 1 GO:0004872,GO:0005783,GO:0005789,GO:0006613,GO:0016021,GO:0016032 receptor activity|endoplasmic reticulum|endoplasmic reticulum membrane|cotranslational protein targeting to membrane|integral component of membrane|viral process hsa04141 Protein processing in endoplasmic reticulum TRAM1L1 34.5754492553357 32.3152865638621 36.8356119468094 1.13988195258656 0.188884425060008 0.719826503540445 1 0.802702 0.815682 1.07794 0.813022 GeneID:133022,Genbank:NM_152402.2,HGNC:HGNC:28371,MIM:617505 translocation associated membrane protein 1 like 1 GO:0005789,GO:0015031,GO:0016021 endoplasmic reticulum membrane|protein transport|integral component of membrane TRAM2 5497.7229209801 5607.79211016516 5387.65373179504 0.960744197708206 -0.0577757365452899 0.680213752978721 1 34.335 34.0695 37.7517 29.1537 GeneID:9697,Genbank:NM_012288.3,HGNC:HGNC:16855,MIM:608485 translocation associated membrane protein 2 GO:0015031,GO:0016021,GO:0032964,GO:0045048 protein transport|integral component of membrane|collagen biosynthetic process|protein insertion into ER membrane TRANK1 451.576848832898 251.959259186711 651.194438479084 2.58452275411925 1.36989790381642 0.276593872028711 1 0.727906 0.716456 3.05696 0.777228 GeneID:9881,Genbank:XM_017007571.1,HGNC:HGNC:29011 tetratricopeptide repeat and ankyrin repeat containing 1 TRAP1 982.203245339988 1052.39531670539 912.011173974589 0.866605124041902 -0.206553327919877 0.1710775909245 1 12.8963 13.7173 11.0527 11.9245 GeneID:10131,Genbank:NM_001272049.1,HGNC:HGNC:16264,MIM:606219 TNF receptor associated protein 1 TRAPPC1 2141.72729698853 1891.36370153421 2392.09089244286 1.26474399952927 0.338845394417052 0.0164725006715161 0.534055811244943 96.3541 99.6327 130.545 124.179 GeneID:58485,Genbank:NM_001166621.1,HGNC:HGNC:19894,MIM:610969 trafficking protein particle complex 1 GO:0000139,GO:0005576,GO:0005783,GO:0005829,GO:0006888,GO:0017112,GO:0030008,GO:0035578,GO:0043312,GO:0048208 Golgi membrane|extracellular region|endoplasmic reticulum|cytosol|ER to Golgi vesicle-mediated transport|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|azurophil granule lumen|neutrophil degranulation|COPII vesicle coating TRAPPC10 800.077322174365 836.814977121398 763.339667227332 0.912196468869598 -0.132583509381653 0.404649426578573 1 2.62482 2.60094 2.70607 2.26463 GeneID:7109,Genbank:NM_003274.4,HGNC:HGNC:11868,MIM:602103 trafficking protein particle complex 10 GO:0000139,GO:0005829,GO:0006814,GO:0006891,GO:0015081,GO:0016021,GO:0017112,GO:0030008,GO:0034498,GO:0048208,GO:0051259,GO:1990071 Golgi membrane|cytosol|sodium ion transport|intra-Golgi vesicle-mediated transport|sodium ion transmembrane transporter activity|integral component of membrane|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|early endosome to Golgi transport|COPII vesicle coating|protein oligomerization|TRAPPII protein complex TRAPPC11 376.190110814308 370.937697655308 381.442523973307 1.02831965147894 0.0402887936375296 0.855152706053647 1 2.49295 1.82616 2.63369 2.04743 GeneID:60684,Genbank:NM_021942.5,HGNC:HGNC:25751,MIM:614138 trafficking protein particle complex 11 GO:0005794,GO:0005829,GO:0006888,GO:0007030,GO:0017112,GO:0030008,GO:0051259,GO:0061635 Golgi apparatus|cytosol|ER to Golgi vesicle-mediated transport|Golgi organization|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|protein oligomerization|regulation of protein complex stability TRAPPC12 864.954712805747 795.583369773788 934.326055837706 1.17439113402203 0.23191298181664 0.144518165051273 1 2.53276 2.77907 3.30606 3.29773 GeneID:51112,Genbank:XM_011510350.2,HGNC:HGNC:24284,MIM:614139 trafficking protein particle complex 12 GO:0000776,GO:0004175,GO:0005634,GO:0005793,GO:0005829,GO:0006888,GO:0007030,GO:0017112,GO:0030008,GO:0051259,GO:0051310,GO:0090234,GO:1905342 kinetochore|endopeptidase activity|nucleus|endoplasmic reticulum-Golgi intermediate compartment|cytosol|ER to Golgi vesicle-mediated transport|Golgi organization|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|protein oligomerization|metaphase plate congression|regulation of kinetochore assembly|positive regulation of protein localization to kinetochore TRAPPC13 379.303469462339 404.820267975267 353.786670949411 0.873935173055679 -0.194401827724166 0.300894586064537 1 4.57953 4.79127 4.2652 3.79239 GeneID:80006,Genbank:NM_001093755.1,HGNC:HGNC:25828 trafficking protein particle complex 13 GO:0005829,GO:0017112 cytosol|Rab guanyl-nucleotide exchange factor activity TRAPPC2 128.19968197973 132.335844836139 124.063519123321 0.937489908927836 -0.0931249333708101 0.757619288911737 1 2.20185 1.87025 2.19577 1.99021 GeneID:6399,Genbank:NM_014563.5,HGNC:HGNC:23068,MIM:300202 trafficking protein particle complex 2 GO:0000139,GO:0001501,GO:0005634,GO:0005654,GO:0005783,GO:0005793,GO:0005829,GO:0006351,GO:0006355,GO:0006888,GO:0008134,GO:0017112,GO:0030008,GO:0043231,GO:0044325,GO:0048208,GO:0048471 Golgi membrane|skeletal system development|nucleus|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|ER to Golgi vesicle-mediated transport|transcription factor binding|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|intracellular membrane-bounded organelle|ion channel binding|COPII vesicle coating|perinuclear region of cytoplasm TRAPPC2B 103.229729072796 92.5832433486549 113.876214796937 1.22998731388244 0.298643435651285 0.307050025538385 1 10.7027 12.6592 11.2851 14.4907 GeneID:10597,Genbank:NM_001355204.1,HGNC:HGNC:10710 trafficking protein particle complex 2B GO:0000139,GO:0001501,GO:0005634,GO:0005654,GO:0005783,GO:0005793,GO:0005829,GO:0006351,GO:0006355,GO:0006888,GO:0008134,GO:0017112,GO:0030008,GO:0043231,GO:0044325,GO:0048208,GO:0048471 Golgi membrane|skeletal system development|nucleus|nucleoplasm|endoplasmic reticulum|endoplasmic reticulum-Golgi intermediate compartment|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|ER to Golgi vesicle-mediated transport|transcription factor binding|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|intracellular membrane-bounded organelle|ion channel binding|COPII vesicle coating|perinuclear region of cytoplasm TRAPPC2L 773.398906050911 735.632996602428 811.164815499394 1.10267595288114 0.141008883533343 0.623284109152792 1 4.26231 5.47387 4.91837 5.99703 GeneID:51693,Genbank:NM_001318524.1,HGNC:HGNC:30887,MIM:610970 trafficking protein particle complex 2 like GO:0000139,GO:0005783,GO:0005829,GO:0017112,GO:0030008,GO:0043231,GO:0048208,GO:0048471,GO:0051259 Golgi membrane|endoplasmic reticulum|cytosol|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|intracellular membrane-bounded organelle|COPII vesicle coating|perinuclear region of cytoplasm|protein oligomerization TRAPPC3 2100.34310894728 2092.17323847372 2108.51297942084 1.00780993688603 0.0112235862918265 0.948621363920606 1 35.7776 37.5806 36.6431 37.143 GeneID:27095,Genbank:NM_001270895.1,HGNC:HGNC:19942,MIM:610955 trafficking protein particle complex 3 GO:0000139,GO:0005783,GO:0005794,GO:0005829,GO:0017112,GO:0030008,GO:0048208 Golgi membrane|endoplasmic reticulum|Golgi apparatus|cytosol|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|COPII vesicle coating TRAPPC3L 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0450326 0 0 0 GeneID:100128327,Genbank:NM_001139444.2,HGNC:HGNC:21090,MIM:614137 trafficking protein particle complex 3 like GO:0005783,GO:0005794,GO:0030008,GO:0048193 endoplasmic reticulum|Golgi apparatus|TRAPP complex|Golgi vesicle transport TRAPPC4 746.867834413864 782.812087357572 710.923581470156 0.908166331296595 -0.13897154256887 0.387896592708186 1 24.6801 24.2348 22.6037 22.964 GeneID:51399,Genbank:NM_001318492.1,HGNC:HGNC:19943,MIM:610971 trafficking protein particle complex 4 GO:0000139,GO:0005783,GO:0005795,GO:0005829,GO:0006888,GO:0008021,GO:0016358,GO:0017112,GO:0030008,GO:0030425,GO:0045202,GO:0048208 Golgi membrane|endoplasmic reticulum|Golgi stack|cytosol|ER to Golgi vesicle-mediated transport|synaptic vesicle|dendrite development|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|dendrite|synapse|COPII vesicle coating TRAPPC5 701.63881517349 642.991918323981 760.285712022999 1.18241876819347 0.241741074262429 0.404517261575846 1 61.9474 72.4309 73.1809 91.9291 GeneID:126003,Genbank:NM_174894.2,HGNC:HGNC:23067 trafficking protein particle complex 5 GO:0000139,GO:0005783,GO:0005829,GO:0017112,GO:0030008,GO:0048208 Golgi membrane|endoplasmic reticulum|cytosol|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|COPII vesicle coating TRAPPC6A 157.937133971985 151.592708336531 164.281559607439 1.08370357261999 0.115970187693337 0.656484368636914 1 1.51168 1.39991 1.7948 1.91415 GeneID:79090,Genbank:NM_001270893.1,HGNC:HGNC:23069,MIM:610396 trafficking protein particle complex 6A GO:0000139,GO:0005783,GO:0005801,GO:0005802,GO:0005829,GO:0006888,GO:0017112,GO:0030008,GO:0048208,GO:1903232 Golgi membrane|endoplasmic reticulum|cis-Golgi network|trans-Golgi network|cytosol|ER to Golgi vesicle-mediated transport|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|COPII vesicle coating|melanosome assembly TRAPPC6B 281.694959312479 300.205753640887 263.184164984071 0.876679283432051 -0.189878938450111 0.464050591161971 1 3.48875 2.68605 3.38496 2.28554 GeneID:122553,Genbank:NM_177452.3,HGNC:HGNC:23066,MIM:610397 trafficking protein particle complex 6B GO:0000139,GO:0005783,GO:0005801,GO:0005802,GO:0005829,GO:0006888,GO:0017112,GO:0030008,GO:0048208 Golgi membrane|endoplasmic reticulum|cis-Golgi network|trans-Golgi network|cytosol|ER to Golgi vesicle-mediated transport|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|COPII vesicle coating TRAPPC8 120.688744379692 129.89529648146 111.482192277923 0.858246567025115 -0.220535913454318 0.431991029562486 1 0.699808 0.672527 0.740587 0.448646 GeneID:22878,Genbank:NM_014939.3,HGNC:HGNC:29169,MIM:614136 trafficking protein particle complex 8 GO:0000407,GO:0005829,GO:0006888,GO:0007030,GO:0017112,GO:0030008,GO:0030242,GO:0031410,GO:0034497,GO:0044804,GO:1990072 phagophore assembly site|cytosol|ER to Golgi vesicle-mediated transport|Golgi organization|Rab guanyl-nucleotide exchange factor activity|TRAPP complex|autophagy of peroxisome|cytoplasmic vesicle|protein localization to phagophore assembly site|autophagy of nucleus|TRAPPIII protein complex TRAPPC9 496.284823785739 468.220758270544 524.348889300935 1.11987535802067 0.16333816945066 0.347780173026193 1 1.16304 1.15346 1.35703 1.35442 GeneID:83696,Genbank:NM_031466.7,HGNC:HGNC:30832,MIM:611966 trafficking protein particle complex 9 GO:0000139,GO:0005783,GO:0005802,GO:0005829,GO:0017112,GO:0021987,GO:0030008,GO:0030182,GO:0048208,GO:0051092 Golgi membrane|endoplasmic reticulum|trans-Golgi network|cytosol|Rab guanyl-nucleotide exchange factor activity|cerebral cortex development|TRAPP complex|neuron differentiation|COPII vesicle coating|positive regulation of NF-kappaB transcription factor activity TRDMT1 161.635673356173 189.029222983176 134.24212372917 0.710165981802287 -0.493771840499444 0.0476950256146827 0.802536542499949 0.350756 0.307024 0.245825 0.20304 GeneID:1787,Genbank:NM_001321006.1,HGNC:HGNC:2977,MIM:602478 tRNA aspartic acid methyltransferase 1 GO:0001975,GO:0003723,GO:0005654,GO:0005737,GO:0006400,GO:0008175,GO:0016428,GO:0030488 response to amphetamine|RNA binding|nucleoplasm|cytoplasm|tRNA modification|tRNA methyltransferase activity|tRNA (cytosine-5-)-methyltransferase activity|tRNA methylation TRERF1 200.788620360207 213.522984425936 188.054256294477 0.880721374329175 -0.183242415640561 0.427299324500472 1 0.645159 0.586534 0.594681 0.499897 GeneID:55809,Genbank:NM_033502.3,HGNC:HGNC:18273,MIM:610322 transcriptional regulating factor 1 GO:0000118,GO:0001104,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0005730,GO:0005829,GO:0006351,GO:0006357,GO:0006694,GO:0006707,GO:0007275,GO:0008134,GO:0008301,GO:0030374,GO:0042592,GO:0044212,GO:0045893,GO:0046872,GO:0046885 histone deacetylase complex|RNA polymerase II transcription cofactor activity|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|nucleolus|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|steroid biosynthetic process|cholesterol catabolic process|multicellular organism development|transcription factor binding|DNA binding, bending|ligand-dependent nuclear receptor transcription coactivator activity|homeostatic process|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|metal ion binding|regulation of hormone biosynthetic process TREX1 438.029722281955 356.477720971721 519.581723592189 1.45754332746479 0.543538770142418 0.0212521861246894 0.598036670329243 10.9168 12.6767 20.6486 14.7416 GeneID:11277,Genbank:NM_007248.4,HGNC:HGNC:12269,MIM:606609 three prime repair exonuclease 1 hsa04623 Cytosolic DNA-sensing pathway TREX2 14.0418094933816 11.6078261678139 16.4757928189492 1.41936936173572 0.505250070020971 0.553068675807017 1 0.251868 0.737741 0.632859 0.753484 GeneID:11219,Genbank:NM_080701.3,HGNC:HGNC:12270,MIM:300370 three prime repair exonuclease 2 TRHDE 85.1619518242037 97.6280361922834 72.6958674561241 0.744620810695669 -0.42542215762906 0.186251695364129 1 0.426133 0.360617 0.297614 0.285198 GeneID:29953,Genbank:XM_017019244.1,HGNC:HGNC:30748,MIM:606950 thyrotropin releasing hormone degrading enzyme GO:0004177,GO:0005737,GO:0005887,GO:0007165,GO:0007267,GO:0008217,GO:0008270,GO:0042277,GO:0043171,GO:0070006,GO:0070062 aminopeptidase activity|cytoplasm|integral component of plasma membrane|signal transduction|cell-cell signaling|regulation of blood pressure|zinc ion binding|peptide binding|peptide catabolic process|metalloaminopeptidase activity|extracellular exosome TRIAP1 449.12260628651 482.452446237523 415.792766335496 0.86183160553567 -0.214522088208056 0.22325771364662 1 18.8259 21.5492 17.2529 17.8883 GeneID:51499,Genbank:NM_016399.2,HGNC:HGNC:26937,MIM:614943 TP53 regulated inhibitor of apoptosis 1 TRIB1 207.466388485976 193.949554312965 220.983222658988 1.13938505010638 0.188255381815422 0.41603448679938 1 2.1625 2.36697 2.60021 2.727 GeneID:10221,Genbank:NM_025195.3,HGNC:HGNC:16891,MIM:609461 tribbles pseudokinase 1 GO:0004860,GO:0005634,GO:0005737,GO:0006469,GO:0007254,GO:0008134,GO:0014912,GO:0031434,GO:0031625,GO:0031665,GO:0032436,GO:0032496,GO:0043405,GO:0043433,GO:0045645,GO:0045651,GO:0045659,GO:0048662,GO:0055106 protein kinase inhibitor activity|nucleus|cytoplasm|negative regulation of protein kinase activity|JNK cascade|transcription factor binding|negative regulation of smooth muscle cell migration|mitogen-activated protein kinase kinase binding|ubiquitin protein ligase binding|negative regulation of lipopolysaccharide-mediated signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|response to lipopolysaccharide|regulation of MAP kinase activity|negative regulation of DNA binding transcription factor activity|positive regulation of eosinophil differentiation|positive regulation of macrophage differentiation|negative regulation of neutrophil differentiation|negative regulation of smooth muscle cell proliferation|ubiquitin-protein transferase regulator activity TRIB2 2659.16785091229 2168.63113483161 3149.70456699296 1.45239294797708 0.538431830332554 9.13292980027533e-05 0.0218317915942104 23.9314 23.5088 36.8441 32.6568 GeneID:28951,Genbank:NM_021643.3,HGNC:HGNC:30809,MIM:609462 tribbles pseudokinase 2 GO:0004860,GO:0005634,GO:0005737,GO:0005856,GO:0006469,GO:0008134,GO:0031434,GO:0031625,GO:0032436,GO:0043405,GO:0045081,GO:0045599,GO:0055106 protein kinase inhibitor activity|nucleus|cytoplasm|cytoskeleton|negative regulation of protein kinase activity|transcription factor binding|mitogen-activated protein kinase kinase binding|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|negative regulation of interleukin-10 biosynthetic process|negative regulation of fat cell differentiation|ubiquitin-protein transferase regulator activity TRIB3 887.830461625789 744.501291111491 1031.15963214009 1.38503404151339 0.469921435421767 0.0702683179569289 0.92021045003939 10.8861 10.9868 13.5247 17.0084 GeneID:57761,Genbank:NM_021158.4,HGNC:HGNC:16228,MIM:607898 tribbles pseudokinase 3 GO:0000122,GO:0003714,GO:0004860,GO:0005524,GO:0005634,GO:0005829,GO:0005886,GO:0006351,GO:0006468,GO:0006469,GO:0010827,GO:0019216,GO:0019901,GO:0031434,GO:0031625,GO:0032092,GO:0032436,GO:0032869,GO:0034976,GO:0043405,GO:0045599,GO:0045717,GO:0045892,GO:0051443,GO:0051898,GO:0055106,GO:0070059 negative regulation of transcription from RNA polymerase II promoter|transcription corepressor activity|protein kinase inhibitor activity|ATP binding|nucleus|cytosol|plasma membrane|transcription, DNA-templated|protein phosphorylation|negative regulation of protein kinase activity|regulation of glucose transport|regulation of lipid metabolic process|protein kinase binding|mitogen-activated protein kinase kinase binding|ubiquitin protein ligase binding|positive regulation of protein binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to insulin stimulus|response to endoplasmic reticulum stress|regulation of MAP kinase activity|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of transcription, DNA-templated|positive regulation of ubiquitin-protein transferase activity|negative regulation of protein kinase B signaling|ubiquitin-protein transferase regulator activity|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress hsa04931 Insulin resistance TRIL 39.0610083926627 28.2026102494634 49.9194065358621 1.77002788374214 0.823772087664003 0.0722465455133447 0.929024313086611 0.330896 0.327429 0.632683 0.500237 GeneID:9865,Genbank:NM_014817.3,HGNC:HGNC:22200,MIM:613356 TLR4 interactor with leucine rich repeats GO:0001530,GO:0002718,GO:0006954,GO:0034142,GO:0045087,GO:0046696 lipopolysaccharide binding|regulation of cytokine production involved in immune response|inflammatory response|toll-like receptor 4 signaling pathway|innate immune response|lipopolysaccharide receptor complex TRIM10 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:10107,Genbank:XM_011514225.1,HGNC:HGNC:10072,MIM:605701 tripartite motif containing 10 GO:0005737,GO:0008270,GO:0030218,GO:0045087,GO:0046597 cytoplasm|zinc ion binding|erythrocyte differentiation|innate immune response|negative regulation of viral entry into host cell TRIM11 674.223464438001 655.915054217649 692.531874658353 1.05582555272249 0.0783714871468686 0.641525840091849 1 12.8766 12.6979 13.8676 13.1395 GeneID:81559,Genbank:XM_011544285.3,HGNC:HGNC:16281,MIM:607868 tripartite motif containing 11 GO:0005634,GO:0005737,GO:0005829,GO:0008134,GO:0008270,GO:0019904,GO:0032897,GO:0045087,GO:0045892,GO:0046597,GO:0046598,GO:0050768,GO:0051607,GO:0061630,GO:1902187 nucleus|cytoplasm|cytosol|transcription factor binding|zinc ion binding|protein domain specific binding|negative regulation of viral transcription|innate immune response|negative regulation of transcription, DNA-templated|negative regulation of viral entry into host cell|positive regulation of viral entry into host cell|negative regulation of neurogenesis|defense response to virus|ubiquitin protein ligase activity|negative regulation of viral release from host cell TRIM13 163.451392009016 171.329834583773 155.572949434258 0.908031866208276 -0.139185166959325 0.565245258167257 1 1.03209 1.18752 1.02209 0.80673 GeneID:10206,Genbank:NM_213590.2,HGNC:HGNC:9976,MIM:605661 tripartite motif containing 13 GO:0004842,GO:0004871,GO:0005737,GO:0005789,GO:0008270,GO:0009653,GO:0010332,GO:0010942,GO:0016021,GO:0016239,GO:0030433,GO:0032897,GO:0043123,GO:0043161,GO:0044322,GO:0045087,GO:0051092,GO:0051865,GO:0097038,GO:1902187,GO:1904264,GO:1904380 ubiquitin-protein transferase activity|signal transducer activity|cytoplasm|endoplasmic reticulum membrane|zinc ion binding|anatomical structure morphogenesis|response to gamma radiation|positive regulation of cell death|integral component of membrane|positive regulation of macroautophagy|ubiquitin-dependent ERAD pathway|negative regulation of viral transcription|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|endoplasmic reticulum quality control compartment|innate immune response|positive regulation of NF-kappaB transcription factor activity|protein autoubiquitination|perinuclear endoplasmic reticulum|negative regulation of viral release from host cell|ubiquitin protein ligase activity involved in ERAD pathway|endoplasmic reticulum mannose trimming TRIM14 1237.96284786109 998.170895877499 1477.75479984468 1.48046272030961 0.566048162314447 0.475055960416088 1 3.28723 3.45325 7.79387 2.71123 GeneID:9830,Genbank:XM_017015352.2,HGNC:HGNC:16283,MIM:606556 tripartite motif containing 14 GO:0005737,GO:0005741,GO:0008270,GO:0032897,GO:0045087,GO:0051091,GO:0051092 cytoplasm|mitochondrial outer membrane|zinc ion binding|negative regulation of viral transcription|innate immune response|positive regulation of DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity TRIM16 1975.12896099449 2009.93053784171 1940.32738414726 0.96537036858538 -0.0508455500097554 0.714368467299562 1 20.3471 22.6261 19.8124 22.0247 GeneID:10626,Genbank:NM_001348121.1,HGNC:HGNC:17241,MIM:609505 tripartite motif containing 16 GO:0003677,GO:0005737,GO:0005829,GO:0005886,GO:0008270,GO:0016605,GO:0019966,GO:0032089,GO:0032526,GO:0043966,GO:0043967,GO:0045618,GO:0045893,GO:0046683,GO:0048386,GO:0050718,GO:0060416 DNA binding|cytoplasm|cytosol|plasma membrane|zinc ion binding|PML body|interleukin-1 binding|NACHT domain binding|response to retinoic acid|histone H3 acetylation|histone H4 acetylation|positive regulation of keratinocyte differentiation|positive regulation of transcription, DNA-templated|response to organophosphorus|positive regulation of retinoic acid receptor signaling pathway|positive regulation of interleukin-1 beta secretion|response to growth hormone TRIM16L 1958.12891109446 1977.83678234191 1938.421039847 0.980071286545574 -0.0290414058580583 0.816982783455425 1 17.358 20.483 18.1159 19.5841 GeneID:147166,Genbank:XM_017024247.1,HGNC:HGNC:32670 tripartite motif containing 16 like GO:0003677,GO:0005737,GO:0005829,GO:0005886,GO:0008270,GO:0016605,GO:0019966,GO:0032089,GO:0032526,GO:0043966,GO:0043967,GO:0045618,GO:0045893,GO:0046683,GO:0048386,GO:0050718,GO:0060416 DNA binding|cytoplasm|cytosol|plasma membrane|zinc ion binding|PML body|interleukin-1 binding|NACHT domain binding|response to retinoic acid|histone H3 acetylation|histone H4 acetylation|positive regulation of keratinocyte differentiation|positive regulation of transcription, DNA-templated|response to organophosphorus|positive regulation of retinoic acid receptor signaling pathway|positive regulation of interleukin-1 beta secretion|response to growth hormone TRIM17 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0113429 0 GeneID:51127,Genbank:XM_011544210.3,HGNC:HGNC:13430,MIM:606123 tripartite motif containing 17 GO:0004842,GO:0005622,GO:0006914,GO:0008270,GO:0030674,GO:0032880,GO:0051865 ubiquitin-protein transferase activity|intracellular|autophagy|zinc ion binding|protein binding, bridging|regulation of protein localization|protein autoubiquitination TRIM2 808.289012480845 867.206161695298 749.371863266392 0.864121931284999 -0.2106931977199 0.56208972826445 1 4.391 3.34598 4.0896 2.69176 GeneID:23321,Genbank:XM_017007952.1,HGNC:HGNC:15974,MIM:614141 tripartite motif containing 2 GO:0004842,GO:0005737,GO:0008270,GO:0043523 ubiquitin-protein transferase activity|cytoplasm|zinc ion binding|regulation of neuron apoptotic process TRIM21 318.086574150854 218.759882368304 417.413265933403 1.90808872913291 0.932128260496296 0.213803503653569 1 3.58952 3.56235 10.0625 4.17585 GeneID:6737,Genbank:NM_003141.3,HGNC:HGNC:11312,MIM:109092 tripartite motif containing 21 GO:0000209,GO:0000932,GO:0003677,GO:0003723,GO:0004842,GO:0005634,GO:0005654,GO:0005737,GO:0005776,GO:0005829,GO:0006513,GO:0007049,GO:0008270,GO:0010508,GO:0016567,GO:0030529,GO:0031410,GO:0031648,GO:0032088,GO:0032479,GO:0032897,GO:0034341,GO:0042802,GO:0045087,GO:0045787,GO:0046598,GO:0051091,GO:0051865,GO:0060333,GO:0070206,GO:0090086,GO:1902187 protein polyubiquitination|P-body|DNA binding|RNA binding|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytoplasm|autophagosome|cytosol|protein monoubiquitination|cell cycle|zinc ion binding|positive regulation of autophagy|protein ubiquitination|intracellular ribonucleoprotein complex|cytoplasmic vesicle|protein destabilization|negative regulation of NF-kappaB transcription factor activity|regulation of type I interferon production|negative regulation of viral transcription|response to interferon-gamma|identical protein binding|innate immune response|positive regulation of cell cycle|positive regulation of viral entry into host cell|positive regulation of DNA binding transcription factor activity|protein autoubiquitination|interferon-gamma-mediated signaling pathway|protein trimerization|negative regulation of protein deubiquitination|negative regulation of viral release from host cell hsa05322 Systemic lupus erythematosus TRIM22 589.518732474641 380.950848103411 798.086616845871 2.09498579887457 1.06694046446751 0.325468622207462 1 4.99325 4.64926 16.0974 4.5128 GeneID:10346,Genbank:NM_006074.4,HGNC:HGNC:16379,MIM:606559 tripartite motif containing 22 GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0006351,GO:0006355,GO:0006955,GO:0008270,GO:0009615,GO:0010508,GO:0015030,GO:0016032,GO:0016567,GO:0016604,GO:0016607,GO:0016740,GO:0019901,GO:0030674,GO:0032880,GO:0043123,GO:0051091,GO:0051092,GO:0051607,GO:0060333,GO:0070206 DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|Golgi apparatus|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|immune response|zinc ion binding|response to virus|positive regulation of autophagy|Cajal body|viral process|protein ubiquitination|nuclear body|nuclear speck|transferase activity|protein kinase binding|protein binding, bridging|regulation of protein localization|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|defense response to virus|interferon-gamma-mediated signaling pathway|protein trimerization TRIM23 106.690805532825 114.020906520085 99.3607045455641 0.871425316444589 -0.198551068186365 0.520240974175191 1 1.44972 1.21089 1.28474 1.01905 GeneID:373,Genbank:NM_033228.2,HGNC:HGNC:660,MIM:601747 tripartite motif containing 23 GO:0000139,GO:0003676,GO:0003924,GO:0004842,GO:0005525,GO:0005634,GO:0005765,GO:0007264,GO:0008047,GO:0008270,GO:0016032,GO:0016567,GO:0019003,GO:0042802,GO:0045087,GO:0070062 Golgi membrane|nucleic acid binding|GTPase activity|ubiquitin-protein transferase activity|GTP binding|nucleus|lysosomal membrane|small GTPase mediated signal transduction|enzyme activator activity|zinc ion binding|viral process|protein ubiquitination|GDP binding|identical protein binding|innate immune response|extracellular exosome TRIM24 466.705357535482 446.791886753367 486.618828317597 1.08913980478391 0.123189153983929 0.546666632116017 1 3.72397 3.07179 4.14311 3.22016 GeneID:8805,Genbank:NM_015905.2,HGNC:HGNC:11812,MIM:603406 tripartite motif containing 24 TRIM25 3384.69843269441 2858.61105581285 3910.78580957597 1.36807202281806 0.452144183606331 0.454923750424461 1 19.1147 19.7545 37.674 16.8523 GeneID:7706,Genbank:NM_005082.4,HGNC:HGNC:12932,MIM:600453 tripartite motif containing 25 hsa04064,hsa04622,hsa05164 NF-kappa B signaling pathway|RIG-I-like receptor signaling pathway|Influenza A TRIM26 2008.57104604963 1812.4916317844 2204.65046031487 1.2163644905463 0.282575605351362 0.0459189205538021 0.79332376136203 15.5787 16.2913 20.9671 18.4579 GeneID:7726,Genbank:XM_005249378.2,HGNC:HGNC:12962,MIM:600830 tripartite motif containing 26 GO:0003677,GO:0005634,GO:0005829,GO:0008270,GO:0016740,GO:0045087,GO:0046597,GO:0046872,GO:0051091,GO:0060333,GO:1902187 DNA binding|nucleus|cytosol|zinc ion binding|transferase activity|innate immune response|negative regulation of viral entry into host cell|metal ion binding|positive regulation of DNA binding transcription factor activity|interferon-gamma-mediated signaling pathway|negative regulation of viral release from host cell TRIM27 2478.3024893205 2532.55699638292 2424.04798225809 0.957154364430964 -0.0631764817328912 0.637892110755804 1 35.8485 37.5481 35.5077 35.6892 GeneID:5987,Genbank:NM_006510.4,HGNC:HGNC:9975,MIM:602165 tripartite motif containing 27 GO:0000122,GO:0001650,GO:0002820,GO:0003676,GO:0003677,GO:0004714,GO:0004842,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005887,GO:0006351,GO:0006469,GO:0007283,GO:0008270,GO:0008283,GO:0016020,GO:0016605,GO:0031965,GO:0032720,GO:0032897,GO:0034314,GO:0042147,GO:0042802,GO:0045087,GO:0045814,GO:0046872,GO:0051091,GO:0051127,GO:0061630,GO:0070206,GO:0070534,GO:0072643,GO:0090281,GO:1900041,GO:1902187 negative regulation of transcription from RNA polymerase II promoter|fibrillar center|negative regulation of adaptive immune response|nucleic acid binding|DNA binding|transmembrane receptor protein tyrosine kinase activity|ubiquitin-protein transferase activity|nucleus|nucleoplasm|nucleolus|cytoplasm|endosome|early endosome|cytosol|integral component of plasma membrane|transcription, DNA-templated|negative regulation of protein kinase activity|spermatogenesis|zinc ion binding|cell proliferation|membrane|PML body|nuclear membrane|negative regulation of tumor necrosis factor production|negative regulation of viral transcription|Arp2/3 complex-mediated actin nucleation|retrograde transport, endosome to Golgi|identical protein binding|innate immune response|negative regulation of gene expression, epigenetic|metal ion binding|positive regulation of DNA binding transcription factor activity|positive regulation of actin nucleation|ubiquitin protein ligase activity|protein trimerization|protein K63-linked ubiquitination|interferon-gamma secretion|negative regulation of calcium ion import|negative regulation of interleukin-2 secretion|negative regulation of viral release from host cell TRIM28 9981.51015686109 10188.9533608749 9774.06695284731 0.959280762868078 -0.0599749689914444 0.625454074851248 1 133.996 141.543 132.792 137.182 GeneID:10155,Genbank:NM_005762.2,HGNC:HGNC:16384,MIM:601742 tripartite motif containing 28 GO:0000122,GO:0001105,GO:0001837,GO:0003677,GO:0003682,GO:0003700,GO:0003714,GO:0003723,GO:0004672,GO:0004842,GO:0005634,GO:0005654,GO:0005719,GO:0005720,GO:0006281,GO:0006367,GO:0007265,GO:0007566,GO:0008270,GO:0016569,GO:0016925,GO:0031625,GO:0035851,GO:0042993,GO:0043045,GO:0043388,GO:0043565,GO:0045087,GO:0045739,GO:0045869,GO:0045892,GO:0045893,GO:0046777,GO:0051259,GO:0060028,GO:0060669,GO:0070087,GO:0090309,GO:0090575,GO:1901536,GO:1902187,GO:1990841,GO:2000653 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription coactivator activity|epithelial to mesenchymal transition|DNA binding|chromatin binding|DNA binding transcription factor activity|transcription corepressor activity|RNA binding|protein kinase activity|ubiquitin-protein transferase activity|nucleus|nucleoplasm|nuclear euchromatin|nuclear heterochromatin|DNA repair|transcription initiation from RNA polymerase II promoter|Ras protein signal transduction|embryo implantation|zinc ion binding|covalent chromatin modification|protein sumoylation|ubiquitin protein ligase binding|Krueppel-associated box domain binding|positive regulation of transcription factor import into nucleus|DNA methylation involved in embryo development|positive regulation of DNA binding|sequence-specific DNA binding|innate immune response|positive regulation of DNA repair|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|protein autophosphorylation|protein oligomerization|convergent extension involved in axis elongation|embryonic placenta morphogenesis|chromo shadow domain binding|positive regulation of methylation-dependent chromatin silencing|RNA polymerase II transcription factor complex|negative regulation of DNA demethylation|negative regulation of viral release from host cell|promoter-specific chromatin binding|regulation of genetic imprinting TRIM29 9.41538816542949 7.68725495215503 11.143521378704 1.44960996455308 0.535664777551081 0.606671409876898 1 0.0768259 0.0673679 0.0949845 0.0665084 GeneID:23650,Genbank:NM_001330382.1,HGNC:HGNC:17274,MIM:610658 tripartite motif containing 29 GO:0000122,GO:0002039,GO:0003700,GO:0005764,GO:0005913,GO:0006366,GO:0008270,GO:0042802,GO:0045087,GO:0098641,GO:1900181 negative regulation of transcription from RNA polymerase II promoter|p53 binding|DNA binding transcription factor activity|lysosome|cell-cell adherens junction|transcription from RNA polymerase II promoter|zinc ion binding|identical protein binding|innate immune response|cadherin binding involved in cell-cell adhesion|negative regulation of protein localization to nucleus TRIM3 205.354700105735 206.191530706791 204.517869504679 0.991882977945916 -0.0117581729604911 0.95684227789194 1 2.36101 2.5847 2.81817 2.42636 GeneID:10612,Genbank:NM_001248006.1,HGNC:HGNC:10064,MIM:605493 tripartite motif containing 3 GO:0005737,GO:0005769,GO:0005794,GO:0007399,GO:0008022,GO:0008270,GO:0015031,GO:0030425,GO:0061630 cytoplasm|early endosome|Golgi apparatus|nervous system development|protein C-terminus binding|zinc ion binding|protein transport|dendrite|ubiquitin protein ligase activity TRIM31 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0168217 0 0 0 GeneID:11074,Genbank:XM_011514264.1,HGNC:HGNC:16289,MIM:609316 tripartite motif containing 31 GO:0005739,GO:0005829,GO:0008270,GO:0016567,GO:0016740,GO:0032897,GO:0045087,GO:0046597,GO:0051091,GO:0060333,GO:1902186 mitochondrion|cytosol|zinc ion binding|protein ubiquitination|transferase activity|negative regulation of viral transcription|innate immune response|negative regulation of viral entry into host cell|positive regulation of DNA binding transcription factor activity|interferon-gamma-mediated signaling pathway|regulation of viral release from host cell TRIM32 597.898763879738 604.084172470609 591.713355288867 0.979521368468988 -0.0298511293490934 0.843980645717528 1 6.74725 7.6307 7.02855 7.25723 GeneID:22954,Genbank:NM_012210.3,HGNC:HGNC:16380,MIM:602290 tripartite motif containing 32 hsa04120 Ubiquitin mediated proteolysis TRIM33 375.991730919836 402.96482657106 349.018635268612 0.866126798804026 -0.207349847516527 0.627040750232228 1 1.64848 1.35509 1.67225 0.90931 GeneID:51592,Genbank:NM_033020.2,HGNC:HGNC:16290,MIM:605769 tripartite motif containing 33 GO:0000122,GO:0003677,GO:0004842,GO:0005634,GO:0005654,GO:0006351,GO:0008270,GO:0016567,GO:0017015,GO:0030514,GO:0045892,GO:0070410,GO:0070412 negative regulation of transcription from RNA polymerase II promoter|DNA binding|ubiquitin-protein transferase activity|nucleus|nucleoplasm|transcription, DNA-templated|zinc ion binding|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-templated|co-SMAD binding|R-SMAD binding TRIM35 870.773860604916 882.314165263423 859.233555946408 0.973840826515434 -0.0382421106320426 0.805836655950068 1 9.34938 9.41472 9.47412 9.27741 GeneID:23087,Genbank:NM_001304495.1,HGNC:HGNC:16285,MIM:617007 tripartite motif containing 35 GO:0005634,GO:0005737,GO:0006915,GO:0008270,GO:0043065,GO:0045087,GO:0045930,GO:1902187 nucleus|cytoplasm|apoptotic process|zinc ion binding|positive regulation of apoptotic process|innate immune response|negative regulation of mitotic cell cycle|negative regulation of viral release from host cell TRIM36 59.7549457745821 57.4716071971035 62.0382843520607 1.07945970850085 0.110309394883496 0.759308274854649 1 0.482865 0.327533 0.405497 0.353849 GeneID:55521,Genbank:NM_001300752.1,HGNC:HGNC:16280,MIM:609317 tripartite motif containing 36 GO:0000209,GO:0000281,GO:0001669,GO:0004842,GO:0005737,GO:0005829,GO:0005856,GO:0007051,GO:0007340,GO:0008270,GO:0043014,GO:0051726,GO:0070062,GO:0070507 protein polyubiquitination|mitotic cytokinesis|acrosomal vesicle|ubiquitin-protein transferase activity|cytoplasm|cytosol|cytoskeleton|spindle organization|acrosome reaction|zinc ion binding|alpha-tubulin binding|regulation of cell cycle|extracellular exosome|regulation of microtubule cytoskeleton organization TRIM37 1404.04946009518 1475.22071403667 1332.87820615368 0.903511043107916 -0.146385860438701 0.418319362862587 1 6.15048 5.61079 6.12649 4.48998 GeneID:4591,Genbank:XM_017024663.2,HGNC:HGNC:7523,MIM:605073 tripartite motif containing 37 hsa04120 Ubiquitin mediated proteolysis TRIM38 416.801442363692 359.513184931981 474.089699795403 1.31869906213621 0.399115367394957 0.391059816059325 1 1.54246 1.49158 2.62015 1.44003 GeneID:10475,Genbank:NM_006355.4,HGNC:HGNC:10059 tripartite motif containing 38 GO:0004871,GO:0005829,GO:0008270,GO:0016567,GO:0016740,GO:0043123,GO:0046598,GO:0051091,GO:0051092,GO:0060333 signal transducer activity|cytosol|zinc ion binding|protein ubiquitination|transferase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of viral entry into host cell|positive regulation of DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|interferon-gamma-mediated signaling pathway TRIM39 271.093092678488 278.077122314506 264.109063042469 0.94976911744563 -0.0743512483904057 0.707113003944982 1 2.73101 3.20137 2.97147 3.0075 GeneID:56658,Genbank:NM_021253.3,HGNC:HGNC:10065,MIM:605700 tripartite motif containing 39 GO:0005739,GO:0005829,GO:0006915,GO:0008270,GO:0016567,GO:0016740,GO:0042802,GO:2000059,GO:2001235 mitochondrion|cytosol|apoptotic process|zinc ion binding|protein ubiquitination|transferase activity|identical protein binding|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of apoptotic signaling pathway TRIM4 1352.848006349 1322.58123631218 1383.11477638582 1.04576924154953 0.0645645429809406 0.648844762589473 1 15.3781 14.1542 15.9921 15.844 GeneID:89122,Genbank:NM_033091.2,HGNC:HGNC:16275 tripartite motif containing 4 GO:0005737,GO:0005829,GO:0005886,GO:0008270,GO:0016567,GO:0016740,GO:0045087,GO:0070206 cytoplasm|cytosol|plasma membrane|zinc ion binding|protein ubiquitination|transferase activity|innate immune response|protein trimerization TRIM41 1126.23393084743 1051.53084376106 1200.93701793381 1.1420844429426 0.191669324002574 0.212340911329947 1 10.8174 11.7473 13.6065 12.1464 GeneID:90933,Genbank:NM_033549.4,HGNC:HGNC:19013,MIM:610530 tripartite motif containing 41 GO:0005730,GO:0005737,GO:0008270,GO:0016567,GO:0016604,GO:0016740,GO:0042802 nucleolus|cytoplasm|zinc ion binding|protein ubiquitination|nuclear body|transferase activity|identical protein binding TRIM43 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0.0228115 0 0.043766 0 GeneID:129868,Genbank:NM_138800.2,HGNC:HGNC:19015 tripartite motif containing 43 GO:0005622,GO:0008270 intracellular|zinc ion binding TRIM43B 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:653192,Genbank:NM_001164464.1,HGNC:HGNC:37146 tripartite motif containing 43B GO:0005622,GO:0008270 intracellular|zinc ion binding TRIM44 3372.56767967418 3339.90680345452 3405.22855589383 1.01955795663872 0.0279437874964511 0.822222932455286 1 20.0573 19.1804 22.0612 18.1502 GeneID:54765,Genbank:XM_006718254.1,HGNC:HGNC:19016,MIM:612298 tripartite motif containing 44 GO:0001961,GO:0002230,GO:0005622,GO:0008270,GO:0010468,GO:0045893,GO:0050821,GO:0061944,GO:1901224 positive regulation of cytokine-mediated signaling pathway|positive regulation of defense response to virus by host|intracellular|zinc ion binding|regulation of gene expression|positive regulation of transcription, DNA-templated|protein stabilization|negative regulation of protein K48-linked ubiquitination|positive regulation of NIK/NF-kappaB signaling TRIM45 347.34592224443 315.715550714998 378.976293773861 1.20037259145328 0.263482282841016 0.171844175329808 1 1.74724 1.89723 2.27431 2.19094 GeneID:80263,Genbank:XM_011542199.2,HGNC:HGNC:19018,MIM:609318 tripartite motif containing 45 GO:0005654,GO:0005829,GO:0008270,GO:0045171,GO:0060348 nucleoplasm|cytosol|zinc ion binding|intercellular bridge|bone development TRIM46 44.3707409682755 43.1929099562939 45.5485719802571 1.05453816439658 0.0766113081134514 0.91057926876439 1 0.300553 0.464357 0.288014 0.413439 GeneID:80128,Genbank:XM_024449915.1,HGNC:HGNC:19019,MIM:600986 tripartite motif containing 46 GO:0001578,GO:0001764,GO:0005856,GO:0007409,GO:0008270,GO:0043194,GO:0048490,GO:0099612,GO:1904115,GO:1990769 microtubule bundle formation|neuron migration|cytoskeleton|axonogenesis|zinc ion binding|axon initial segment|anterograde synaptic vesicle transport|protein localization to axon|axon cytoplasm|proximal neuron projection TRIM47 1519.54220443325 1632.29350269156 1406.79090617493 0.861849234745598 -0.214492577438842 0.131327516072244 1 37.2262 38.5556 31.452 34.7328 GeneID:91107,Genbank:XM_005257787.4,HGNC:HGNC:19020,MIM:611041 tripartite motif containing 47 GO:0005634,GO:0005829,GO:0008270 nucleus|cytosol|zinc ion binding TRIM5 621.942091691926 594.849251072573 649.034932311279 1.09109145071798 0.125772027388398 0.668370736544911 1 4.73747 5.00808 6.51772 4.01575 GeneID:85363,Genbank:XM_017018462.2,HGNC:HGNC:16276,MIM:608487 tripartite motif containing 5 hsa05170 Human immunodeficiency virus 1 infection TRIM52 107.874809798188 89.7388674862806 126.010752110096 1.4041936971108 0.489741957427839 0.0853603698393596 0.964561165794104 0.41362 0.338864 0.631049 0.519127 GeneID:84851,Genbank:XM_017009991.2,HGNC:HGNC:19024 tripartite motif containing 52 GO:0005622,GO:0008270,GO:0051092 intracellular|zinc ion binding|positive regulation of NF-kappaB transcription factor activity TRIM55 1.99493416203551 1.56626675524197 2.42360156882906 1.54737471169439 0.629822601598113 0.890477131901486 1 0.00926274 0.00863232 0.00881601 0.0082253 GeneID:84675,Genbank:XM_011517614.2,HGNC:HGNC:14215,MIM:606469 tripartite motif containing 55 GO:0004871,GO:0005634,GO:0005737,GO:0005874,GO:0007165,GO:0008270,GO:0042802 signal transducer activity|nucleus|cytoplasm|microtubule|signal transduction|zinc ion binding|identical protein binding TRIM56 1252.95966009312 1069.7006862522 1436.21863393403 1.3426359844322 0.425068214192598 0.192991010926234 1 8.311 8.24095 13.9106 8.89329 GeneID:81844,Genbank:XM_011516589.3,HGNC:HGNC:19028,MIM:616996 tripartite motif containing 56 GO:0003723,GO:0004842,GO:0005737,GO:0005829,GO:0008270,GO:0032479,GO:0032608,GO:0034340,GO:0051607,GO:0070534 RNA binding|ubiquitin-protein transferase activity|cytoplasm|cytosol|zinc ion binding|regulation of type I interferon production|interferon-beta production|response to type I interferon|defense response to virus|protein K63-linked ubiquitination TRIM59 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0119111 0 0 GeneID:286827,Genbank:NM_173084.2,HGNC:HGNC:30834,MIM:616148 tripartite motif containing 59 GO:0005783,GO:0005789,GO:0005813,GO:0005929,GO:0008270,GO:0016021,GO:0030992,GO:0043124,GO:0045087,GO:0046597,GO:0060271,GO:0061630 endoplasmic reticulum|endoplasmic reticulum membrane|centrosome|cilium|zinc ion binding|integral component of membrane|intraciliary transport particle B|negative regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of viral entry into host cell|cilium assembly|ubiquitin protein ligase activity TRIM6 51.1525642893449 47.5359089890094 54.7692195896804 1.15216518952742 0.204347575310606 0.607836991951475 1 0.906479 0.773786 0.945005 0.785478 GeneID:117854,Genbank:NM_058166.4,HGNC:HGNC:16277,MIM:607564 tripartite motif containing 6 GO:0000209,GO:0002230,GO:0002741,GO:0005634,GO:0005737,GO:0005829,GO:0008134,GO:0008270,GO:0010628,GO:0010629,GO:0010800,GO:0010994,GO:0019901,GO:0030674,GO:0032496,GO:0033138,GO:0035458,GO:0045071,GO:0045892,GO:0060340,GO:0061630,GO:0070206,GO:0098586,GO:1990782,GO:2000679,GO:2000737 protein polyubiquitination|positive regulation of defense response to virus by host|positive regulation of cytokine secretion involved in immune response|nucleus|cytoplasm|cytosol|transcription factor binding|zinc ion binding|positive regulation of gene expression|negative regulation of gene expression|positive regulation of peptidyl-threonine phosphorylation|free ubiquitin chain polymerization|protein kinase binding|protein binding, bridging|response to lipopolysaccharide|positive regulation of peptidyl-serine phosphorylation|cellular response to interferon-beta|negative regulation of viral genome replication|negative regulation of transcription, DNA-templated|positive regulation of type I interferon-mediated signaling pathway|ubiquitin protein ligase activity|protein trimerization|cellular response to virus|protein tyrosine kinase binding|positive regulation of transcription regulatory region DNA binding|negative regulation of stem cell differentiation TRIM62 276.223842410334 331.46446216168 220.983222658988 0.666687527277653 -0.584917358177399 0.00454152961900182 0.266436404314773 2.63487 2.33808 1.67585 1.76605 GeneID:55223,Genbank:XM_017001630.1,HGNC:HGNC:25574,MIM:616755 tripartite motif containing 62 GO:0004842,GO:0005737,GO:0005829,GO:0008270,GO:0010719,GO:0032897,GO:0043123,GO:0045087,GO:0046596,GO:0051091,GO:0051092,GO:0060333,GO:1902186 ubiquitin-protein transferase activity|cytoplasm|cytosol|zinc ion binding|negative regulation of epithelial to mesenchymal transition|negative regulation of viral transcription|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|regulation of viral entry into host cell|positive regulation of DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|interferon-gamma-mediated signaling pathway|regulation of viral release from host cell TRIM63 0.972203168832738 0.490071401957362 1.45433493570811 2.96759804775273 1.56929569647876 0.837430708298891 1 0 0.0164449 0.033845 0.0157185 GeneID:84676,Genbank:NM_032588.3,HGNC:HGNC:16007,MIM:606131 tripartite motif containing 63 GO:0004842,GO:0004871,GO:0005634,GO:0005737,GO:0005874,GO:0006936,GO:0007165,GO:0008270,GO:0010614,GO:0014732,GO:0014878,GO:0030018,GO:0031430,GO:0031432,GO:0051384,GO:0070555 ubiquitin-protein transferase activity|signal transducer activity|nucleus|cytoplasm|microtubule|muscle contraction|signal transduction|zinc ion binding|negative regulation of cardiac muscle hypertrophy|skeletal muscle atrophy|response to electrical stimulus involved in regulation of muscle adaptation|Z disc|M band|titin binding|response to glucocorticoid|response to interleukin-1 TRIM65 1042.30028738235 1134.76451285295 949.836061911747 0.837033632223601 -0.256642503094543 0.0860092214326386 0.964561165794104 11.6967 12.657 10.3639 10.8865 GeneID:201292,Genbank:XM_011524501.2,HGNC:HGNC:27316 tripartite motif containing 65 GO:0005634,GO:0005654,GO:0005829,GO:0008270,GO:0010508 nucleus|nucleoplasm|cytosol|zinc ion binding|positive regulation of autophagy TRIM66 1010.91457893952 1079.31000919261 942.51914868643 0.873260824655459 -0.195515473980695 0.199781875001763 1 0.347427 0.414749 0.517317 0.399293 GeneID:9866,Genbank:NM_014818.1,HGNC:HGNC:29005,MIM:612000 tripartite motif containing 66 GO:0005654,GO:0008270,GO:0016235 nucleoplasm|zinc ion binding|aggresome TRIM68 162.40431166426 171.17594710461 153.63267622391 0.897513224390229 -0.155994898434521 0.52871926612777 1 1.90383 1.91911 1.88654 1.63282 GeneID:55128,Genbank:NM_001304496.1,HGNC:HGNC:21161,MIM:613184 tripartite motif containing 68 GO:0004842,GO:0005634,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0008270,GO:0035035,GO:0048471,GO:0050681,GO:0051865,GO:0060333,GO:0060765 ubiquitin-protein transferase activity|nucleus|nucleolus|cytoplasm|Golgi apparatus|cytosol|zinc ion binding|histone acetyltransferase binding|perinuclear region of cytoplasm|androgen receptor binding|protein autoubiquitination|interferon-gamma-mediated signaling pathway|regulation of androgen receptor signaling pathway TRIM69 16.9351803743104 18.3629645907392 15.5073961578817 0.844493059998732 -0.243842527806886 0.749806299861116 1 0.252104 0.327338 0.240255 0.137887 GeneID:140691,Genbank:NM_182985.4,HGNC:HGNC:17857,MIM:616017 tripartite motif containing 69 GO:0000209,GO:0004842,GO:0005634,GO:0005737,GO:0005829,GO:0006915,GO:0016607,GO:0046872 protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|cytoplasm|cytosol|apoptotic process|nuclear speck|metal ion binding TRIM7 256.590155685638 248.106331555953 265.073979815323 1.06838861448219 0.0954365067711639 0.669738321289296 1 1.02608 1.19407 1.18456 1.27639 GeneID:81786,Genbank:XM_024446224.1,HGNC:HGNC:16278,MIM:609315 tripartite motif containing 7 GO:0005634,GO:0005737,GO:0008270,GO:0016567,GO:0016740 nucleus|cytoplasm|zinc ion binding|protein ubiquitination|transferase activity TRIM71 5.6992451594982 5.58289052027075 5.81559979872566 1.04168257959026 0.0589157280813491 1 1 0.0176843 0.0385262 0.0338025 0.0315087 GeneID:131405,Genbank:NM_001039111.2,HGNC:HGNC:32669 tripartite motif containing 71 GO:0000082,GO:0000932,GO:0001843,GO:0004842,GO:0008270,GO:0008543,GO:0010586,GO:0010608,GO:0017148,GO:0021915,GO:0030371,GO:0035196,GO:0035198,GO:0035278,GO:0051865,GO:0060964,GO:0061158,GO:0061630,GO:0072089,GO:2000177,GO:2000637 G1/S transition of mitotic cell cycle|P-body|neural tube closure|ubiquitin-protein transferase activity|zinc ion binding|fibroblast growth factor receptor signaling pathway|miRNA metabolic process|posttranscriptional regulation of gene expression|negative regulation of translation|neural tube development|translation repressor activity|production of miRNAs involved in gene silencing by miRNA|miRNA binding|miRNA mediated inhibition of translation|protein autoubiquitination|regulation of gene silencing by miRNA|3'-UTR-mediated mRNA destabilization|ubiquitin protein ligase activity|stem cell proliferation|regulation of neural precursor cell proliferation|positive regulation of gene silencing by miRNA hsa05206 MicroRNAs in cancer TRIM73 2.50901870133535 2.59443583384164 2.42360156882906 0.934153597948259 -0.0982683107132426 1 1 0.119679 0.034502 0 0 GeneID:375593,Genbank:NM_198924.3,HGNC:HGNC:18162,MIM:612549 tripartite motif containing 73 GO:0005829,GO:0008270 cytosol|zinc ion binding TRIM74 153.52747237923 175.711051236065 131.343893522395 0.747499332560116 -0.419855803754066 0.100066362695325 1 0.920704 1.12641 1.56823 0.981944 GeneID:378108,Genbank:XM_011516190.2,HGNC:HGNC:17453,MIM:612550 tripartite motif containing 74 GO:0005829,GO:0008270 cytosol|zinc ion binding TRIM8 1785.39720850697 1921.15219584913 1649.6422211648 0.858673365248751 -0.21981865264115 0.114868323643201 1 32.2938 35.1866 29.2564 29.4723 GeneID:81603,Genbank:NM_030912.2,HGNC:HGNC:15579,MIM:606125 tripartite motif containing 8 GO:0005829,GO:0008270,GO:0010508,GO:0016567,GO:0016605,GO:0016740,GO:0019827,GO:0032897,GO:0042802,GO:0042803,GO:0043123,GO:0045087,GO:0046597,GO:0051091,GO:0051092,GO:0060333,GO:1900182,GO:1902187 cytosol|zinc ion binding|positive regulation of autophagy|protein ubiquitination|PML body|transferase activity|stem cell population maintenance|negative regulation of viral transcription|identical protein binding|protein homodimerization activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|innate immune response|negative regulation of viral entry into host cell|positive regulation of DNA binding transcription factor activity|positive regulation of NF-kappaB transcription factor activity|interferon-gamma-mediated signaling pathway|positive regulation of protein localization to nucleus|negative regulation of viral release from host cell TRIM9 217.432403682404 179.4591346632 255.405672701609 1.42319683632121 0.50913520869918 0.0229634420332659 0.613948474678957 0.605238 0.679581 0.950024 0.851683 GeneID:114088,Genbank:XM_017020950.1,HGNC:HGNC:16288,MIM:606555 tripartite motif containing 9 GO:0000149,GO:0004842,GO:0005737,GO:0005829,GO:0005856,GO:0008021,GO:0008270,GO:0016079,GO:0019904,GO:0030054,GO:0030425,GO:0035544,GO:0042803,GO:0043161,GO:0045955 SNARE binding|ubiquitin-protein transferase activity|cytoplasm|cytosol|cytoskeleton|synaptic vesicle|zinc ion binding|synaptic vesicle exocytosis|protein domain specific binding|cell junction|dendrite|negative regulation of SNARE complex assembly|protein homodimerization activity|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of calcium ion-dependent exocytosis TRIML2 2.23366180556391 1.07619535328461 3.3911282578432 3.15103410128402 1.65582536764873 0.50781664188377 1 0 0 0.0346194 0.0807863 GeneID:205860,Genbank:XM_017007882.2,HGNC:HGNC:26378 tripartite motif family like 2 GO:0016567,GO:0016740,GO:0032526 protein ubiquitination|transferase activity|response to retinoic acid TRIO 4730.83846432287 5222.09646952305 4239.58045912269 0.811854105695965 -0.300707603807013 0.0793163563792138 0.945472338172662 9.62282 10.0866 9.50224 6.84616 GeneID:7204,Genbank:XM_017009802.1,HGNC:HGNC:12303,MIM:601893 trio Rho guanine nucleotide exchange factor TRIOBP 1592.15973320696 1407.23912733697 1777.08033907695 1.26281333751703 0.336641403226368 0.02035415511635 0.585494015351855 3.29391 3.50221 4.43054 4.50651 GeneID:11078,Genbank:NM_001039141.2,HGNC:HGNC:17009,MIM:609761 TRIO and F-actin binding protein GO:0005634,GO:0005737,GO:0005815,GO:0005925,GO:0007049,GO:0015629,GO:0017049,GO:0030047,GO:0030496,GO:0031625,GO:0045159,GO:0051015,GO:0051016,GO:0051301,GO:1900026 nucleus|cytoplasm|microtubule organizing center|focal adhesion|cell cycle|actin cytoskeleton|GTP-Rho binding|actin modification|midbody|ubiquitin protein ligase binding|myosin II binding|actin filament binding|barbed-end actin filament capping|cell division|positive regulation of substrate adhesion-dependent cell spreading TRIP10 2327.18877314441 2281.15646918392 2373.22107710489 1.0403587431045 0.0570810934182276 0.706707069870333 1 22.919 26.305 25.8907 25.1222 GeneID:9322,Genbank:NM_001288962.1,HGNC:HGNC:12304,MIM:604504 thyroid hormone receptor interactor 10 GO:0001891,GO:0005096,GO:0005654,GO:0005737,GO:0005764,GO:0005794,GO:0005829,GO:0005856,GO:0005938,GO:0006897,GO:0007154,GO:0007165,GO:0008289,GO:0030036,GO:0042802,GO:0042995,GO:0043231,GO:0048471,GO:0051056,GO:0061024,GO:0070062 phagocytic cup|GTPase activator activity|nucleoplasm|cytoplasm|lysosome|Golgi apparatus|cytosol|cytoskeleton|cell cortex|endocytosis|cell communication|signal transduction|lipid binding|actin cytoskeleton organization|identical protein binding|cell projection|intracellular membrane-bounded organelle|perinuclear region of cytoplasm|regulation of small GTPase mediated signal transduction|membrane organization|extracellular exosome hsa04910 Insulin signaling pathway TRIP11 76.04118335772 70.6457001201594 81.4366665952806 1.1527476754674 0.205076756537054 0.627600315265205 1 0.211463 0.200734 0.341791 0.196882 GeneID:9321,Genbank:NM_001321851.1,HGNC:HGNC:12305,MIM:604505 thyroid hormone receptor interactor 11 TRIP12 3135.50857558398 3233.47608233636 3037.54106883159 0.939404217468899 -0.0901820242767511 0.656817743485815 1 7.36113 6.94256 7.8519 5.49632 GeneID:9320,Genbank:XM_024453223.1,HGNC:HGNC:12306,MIM:604506 thyroid hormone receptor interactor 12 GO:0000209,GO:0004842,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006281,GO:0006974,GO:0016607,GO:0042787,GO:0045995,GO:0046966,GO:0061630,GO:1901315,GO:2000780 protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytoplasm|cytosol|DNA repair|cellular response to DNA damage stimulus|nuclear speck|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of embryonic development|thyroid hormone receptor binding|ubiquitin protein ligase activity|negative regulation of histone H2A K63-linked ubiquitination|negative regulation of double-strand break repair hsa04120 Ubiquitin mediated proteolysis TRIP13 1948.87917390703 2114.79194120206 1782.966406612 0.843093058884342 -0.246236213208439 0.0804515843285641 0.951623427935096 24.7634 25.3486 22.2369 20.8642 GeneID:9319,Genbank:NM_004237.3,HGNC:HGNC:12307,MIM:604507 thyroid hormone receptor interactor 13 GO:0001556,GO:0001673,GO:0003712,GO:0005524,GO:0005634,GO:0006302,GO:0006366,GO:0007094,GO:0007130,GO:0007131,GO:0007141,GO:0007144,GO:0007283,GO:0007286,GO:0042802,GO:0048477 oocyte maturation|male germ cell nucleus|transcription cofactor activity|ATP binding|nucleus|double-strand break repair|transcription from RNA polymerase II promoter|mitotic spindle assembly checkpoint|synaptonemal complex assembly|reciprocal meiotic recombination|male meiosis I|female meiosis I|spermatogenesis|spermatid development|identical protein binding|oogenesis TRIP4 517.329895230255 543.747555100061 490.912235360449 0.902831158974336 -0.147471884463478 0.409992394347923 1 7.43105 7.03412 6.28538 6.44763 GeneID:9325,Genbank:NM_016213.4,HGNC:HGNC:12310,MIM:604501 thyroid hormone receptor interactor 4 GO:0002020,GO:0003713,GO:0005634,GO:0005654,GO:0005737,GO:0005815,GO:0005829,GO:0006351,GO:0006355,GO:0008270,GO:0016604,GO:0016922,GO:0019901,GO:0030331,GO:0030520,GO:0031594,GO:0035035,GO:0043234,GO:0044389,GO:0045661,GO:0045893,GO:0099053,GO:1901998 protease binding|transcription coactivator activity|nucleus|nucleoplasm|cytoplasm|microtubule organizing center|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|nuclear body|ligand-dependent nuclear receptor binding|protein kinase binding|estrogen receptor binding|intracellular estrogen receptor signaling pathway|neuromuscular junction|histone acetyltransferase binding|protein complex|ubiquitin-like protein ligase binding|regulation of myoblast differentiation|positive regulation of transcription, DNA-templated|activating signal cointegrator 1 complex|toxin transport TRIP6 7343.05408772201 7009.39763105805 7676.71054438597 1.09520260491017 0.131197783124192 0.331665038706275 1 176.212 183.584 195.23 204.149 GeneID:7205,Genbank:NM_003302.2,HGNC:HGNC:12311,MIM:602933 thyroid hormone receptor interactor 6 GO:0003723,GO:0005149,GO:0005634,GO:0005829,GO:0005856,GO:0005886,GO:0005925,GO:0006351,GO:0006355,GO:0008588,GO:0019900,GO:0030335,GO:0046872,GO:0046966,GO:0048041 RNA binding|interleukin-1 receptor binding|nucleus|cytosol|cytoskeleton|plasma membrane|focal adhesion|transcription, DNA-templated|regulation of transcription, DNA-templated|release of cytoplasmic sequestered NF-kappaB|kinase binding|positive regulation of cell migration|metal ion binding|thyroid hormone receptor binding|focal adhesion assembly hsa04621 NOD-like receptor signaling pathway TRIQK 164.42464198409 174.721099777042 154.128184191138 0.882138358720367 -0.180923142296088 0.571127199677376 1 1.87999 1.27684 1.52083 1.18845 GeneID:286144,Genbank:XM_017013350.1,HGNC:HGNC:27828 triple QxxK/R motif containing GO:0005789,GO:0016021 endoplasmic reticulum membrane|integral component of membrane TRIR 4750.97856561785 4899.33965673873 4602.61747449698 0.939436290800205 -0.0901327683278599 0.55886542748033 1 249.732 254.353 222.614 255.612 GeneID:79002,Genbank:NM_001329739.1,HGNC:HGNC:28424 telomerase RNA component interacting RNase GO:0003723,GO:0008408,GO:0008409,GO:0016075,GO:0090503 RNA binding|3'-5' exonuclease activity|5'-3' exonuclease activity|rRNA catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic TRIT1 336.567024326812 370.23692084525 302.897127808375 0.818117023869098 -0.289620873138074 0.139393146207582 1 4.03013 3.74143 3.28687 3.1767 GeneID:54802,Genbank:NM_001312692.1,HGNC:HGNC:20286,MIM:617840 tRNA isopentenyltransferase 1 GO:0003676,GO:0005524,GO:0005739,GO:0005759,GO:0006400,GO:0008270,GO:0052381,GO:0070900 nucleic acid binding|ATP binding|mitochondrion|mitochondrial matrix|tRNA modification|zinc ion binding|tRNA dimethylallyltransferase activity|mitochondrial tRNA modification TRMO 243.332761401901 261.808713500543 224.856809303258 0.858859150624836 -0.219506540189926 0.302176976546011 1 1.08214 1.24174 0.957783 1.14469 GeneID:51531,Genbank:XM_011518776.3,HGNC:HGNC:30967 tRNA methyltransferase O GO:0016430,GO:0030488 tRNA (adenine-N6-)-methyltransferase activity|tRNA methylation TRMT1 837.456741293603 865.134274231301 809.779208355905 0.936015636503846 -0.0953954640977756 0.522315306365036 1 6.70464 7.79327 6.69102 7.3196 GeneID:55621,Genbank:NM_001351761.1,HGNC:HGNC:25980,MIM:611669 tRNA methyltransferase 1 GO:0000049,GO:0002940,GO:0003723,GO:0004809,GO:0005634,GO:0005654,GO:0005739,GO:0006400,GO:0046872 tRNA binding|tRNA N2-guanine methylation|RNA binding|tRNA (guanine-N2-)-methyltransferase activity|nucleus|nucleoplasm|mitochondrion|tRNA modification|metal ion binding TRMT10A 39.0859284292334 38.4362747607751 39.7355820976917 1.03380419525574 0.047962961974302 0.94897913517351 1 0.352765 0.366994 0.364807 0.424385 GeneID:93587,Genbank:NM_001134666.2,HGNC:HGNC:28403,MIM:616013 tRNA methyltransferase 10A GO:0000049,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0009019,GO:0015629,GO:0030488,GO:0052905,GO:0070062 tRNA binding|RNA binding|nucleus|nucleoplasm|nucleolus|cytosol|tRNA (guanine-N1-)-methyltransferase activity|actin cytoskeleton|tRNA methylation|tRNA (guanine(9)-N(1))-methyltransferase activity|extracellular exosome TRMT10B 113.039378636152 109.764151381632 116.314605890673 1.05967753976676 0.0836253189825732 0.763329539375289 1 0.373871 0.302339 0.353676 0.333695 GeneID:158234,Genbank:XM_011517743.2,HGNC:HGNC:26454 tRNA methyltransferase 10B GO:0005829,GO:0009019,GO:0052905 cytosol|tRNA (guanine-N1-)-methyltransferase activity|tRNA (guanine(9)-N(1))-methyltransferase activity TRMT10C 202.616877745475 236.593540936654 168.640214554297 0.71278452440698 -0.488462080703838 0.174123113195468 1 6.44709 4.60047 3.82303 4.16697 GeneID:54931,Genbank:NM_017819.3,HGNC:HGNC:26022,MIM:615423 tRNA methyltransferase 10C, mitochondrial RNase P subunit GO:0000049,GO:0000964,GO:0003723,GO:0005654,GO:0005739,GO:0005759,GO:0009019,GO:0016429,GO:0030678,GO:0042645,GO:0052905,GO:0061953,GO:0070131,GO:0070901,GO:0080009,GO:0090646,GO:0097745,GO:1990180 tRNA binding|mitochondrial RNA 5'-end processing|RNA binding|nucleoplasm|mitochondrion|mitochondrial matrix|tRNA (guanine-N1-)-methyltransferase activity|tRNA (adenine-N1-)-methyltransferase activity|mitochondrial ribonuclease P complex|mitochondrial nucleoid|tRNA (guanine(9)-N(1))-methyltransferase activity|mRNA (adenine-N1-)-methyltransferase activity|positive regulation of mitochondrial translation|mitochondrial tRNA methylation|mRNA methylation|mitochondrial tRNA processing|mitochondrial tRNA 5'-end processing|mitochondrial tRNA 3'-end processing TRMT11 248.269156355601 265.353866172976 231.184446538226 0.871230745089367 -0.198873228292012 0.367359443069751 1 2.84178 2.63775 2.56357 2.13862 GeneID:60487,Genbank:NM_001350593.1,HGNC:HGNC:21080 tRNA methyltransferase 11 homolog GO:0000049,GO:0004809 tRNA binding|tRNA (guanine-N2-)-methyltransferase activity TRMT112 2767.1575758432 2811.4045730941 2722.91057859231 0.968523208879755 -0.0461414741078365 0.769543790165238 1 33.244 37.9117 34.044 38.5251 GeneID:51504,Genbank:NM_001286082.1,HGNC:HGNC:26940 tRNA methyltransferase subunit 11-2 GO:0005654,GO:0005829,GO:0006415,GO:0008276,GO:0018364,GO:0030488,GO:0031167,GO:0032259,GO:0043234,GO:0046982,GO:0048471,GO:0070062,GO:0070476,GO:2000234 nucleoplasm|cytosol|translational termination|protein methyltransferase activity|peptidyl-glutamine methylation|tRNA methylation|rRNA methylation|methylation|protein complex|protein heterodimerization activity|perinuclear region of cytoplasm|extracellular exosome|rRNA (guanine-N7)-methylation|positive regulation of rRNA processing TRMT12 221.413063715285 218.433507100618 224.392620329952 1.02728113149138 0.038831051671474 0.885234101831896 1 3.77502 4.33296 4.60733 3.88422 GeneID:55039,Genbank:NM_017956.3,HGNC:HGNC:26091,MIM:611244 tRNA methyltransferase 12 homolog GO:0008033,GO:0102522 tRNA processing|tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity TRMT13 103.517954223466 103.306979261924 103.728929185009 1.00408442804251 0.00588058283169952 0.995800657933463 1 0.829749 0.836307 0.962639 0.611563 GeneID:54482,Genbank:XM_005270945.3,HGNC:HGNC:25502 tRNA methyltransferase 13 homolog GO:0008175,GO:0030488,GO:0046872 tRNA methyltransferase activity|tRNA methylation|metal ion binding TRMT1L 239.19587260271 243.300653084895 235.091092120525 0.966257546536446 -0.0495203182605467 0.93584162584528 1 2.08074 1.46304 2.23377 1.35955 GeneID:81627,Genbank:NM_001202423.1,HGNC:HGNC:16782,MIM:611673 tRNA methyltransferase 1 like GO:0000049,GO:0003723,GO:0004809,GO:0007610,GO:0046872 tRNA binding|RNA binding|tRNA (guanine-N2-)-methyltransferase activity|behavior|metal ion binding TRMT2A 718.608554639594 704.06651312331 733.150596155879 1.04130871514333 0.0583978455623908 0.818559883526088 1 6.79352 6.84897 6.65148 8.14802 GeneID:27037,Genbank:NM_182984.4,HGNC:HGNC:24974,MIM:611151 tRNA methyltransferase 2 homolog A GO:0003723,GO:0006396,GO:0008173 RNA binding|RNA processing|RNA methyltransferase activity TRMT2B 1136.13216772356 1072.82341110758 1199.44092433954 1.11802269779072 0.160949477678159 0.284563029852137 1 6.34416 6.55779 7.57476 7.03183 GeneID:79979,Genbank:XM_017029861.1,HGNC:HGNC:25748 tRNA methyltransferase 2 homolog B GO:0005739,GO:0030697 mitochondrion|S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity TRMT44 257.19329061384 258.00381214447 256.38276908321 0.993716980195811 -0.00909307751416057 0.952678862153798 1 0.896026 1.16097 1.09409 0.852742 GeneID:152992,Genbank:XM_011513410.2,HGNC:HGNC:26653,MIM:614309 tRNA methyltransferase 44 homolog GO:0005737,GO:0016300,GO:0030488,GO:0046872 cytoplasm|tRNA (uracil) methyltransferase activity|tRNA methylation|metal ion binding TRMT5 208.509147469187 237.218899508413 179.799395429962 0.757947177912714 -0.399830785829724 0.076419676544314 0.94157495521624 1.49397 1.51262 1.1497 1.0904 GeneID:57570,Genbank:NM_001350253.1,HGNC:HGNC:23141,MIM:611023 tRNA methyltransferase 5 GO:0005634,GO:0005759,GO:0052906,GO:0070901 nucleus|mitochondrial matrix|tRNA (guanine(37)-N(1))-methyltransferase activity|mitochondrial tRNA methylation TRMT6 502.599634794365 533.67758672302 471.52168286571 0.883532856909037 -0.178644308024096 0.312043211280497 1 6.06349 6.0981 5.25855 5.66185 GeneID:51605,Genbank:XM_017027875.1,HGNC:HGNC:20900 tRNA methyltransferase 6 GO:0003723,GO:0005654,GO:0006400,GO:0030488,GO:0031515,GO:0080009 RNA binding|nucleoplasm|tRNA modification|tRNA methylation|tRNA (m1A) methyltransferase complex|mRNA methylation TRMT61A 693.865628436103 706.854071056746 680.87718581546 0.963250002645595 -0.0540178100401317 0.75596762518969 1 9.26668 11.0338 9.93914 10.351 GeneID:115708,Genbank:NM_152307.2,HGNC:HGNC:23790 tRNA methyltransferase 61A GO:0005634,GO:0005654,GO:0006400,GO:0016429,GO:0031515,GO:0061953,GO:0080009 nucleus|nucleoplasm|tRNA modification|tRNA (adenine-N1-)-methyltransferase activity|tRNA (m1A) methyltransferase complex|mRNA (adenine-N1-)-methyltransferase activity|mRNA methylation TRMT61B 216.880232105602 228.743606851083 205.016857360121 0.896273605992367 -0.157988882970021 0.489561922440986 1 3.29775 3.25806 3.52959 2.90118 GeneID:55006,Genbank:XM_017004401.2,HGNC:HGNC:26070 tRNA methyltransferase 61B GO:0005739,GO:0005759,GO:0016429,GO:0016433,GO:0031515,GO:0051260,GO:0061953,GO:0070901,GO:0080009 mitochondrion|mitochondrial matrix|tRNA (adenine-N1-)-methyltransferase activity|rRNA (adenine) methyltransferase activity|tRNA (m1A) methyltransferase complex|protein homooligomerization|mRNA (adenine-N1-)-methyltransferase activity|mitochondrial tRNA methylation|mRNA methylation TRMT9B 20.821926485983 19.8331787966113 21.8106741753547 1.0997064262377 0.137118438350841 0.880204179022757 1 0.0491568 0.0605413 0.0743185 0.0409713 GeneID:57604,Genbank:NM_020844.2,HGNC:HGNC:26725,MIM:615666 tRNA methyltransferase 9B (putative) GO:0000049,GO:0002098,GO:0005634,GO:0005737,GO:0006400,GO:0008175,GO:0008198,GO:0016300,GO:0016706 tRNA binding|tRNA wobble uridine modification|nucleus|cytoplasm|tRNA modification|tRNA methyltransferase activity|ferrous iron binding|tRNA (uracil) methyltransferase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors TRMU 518.504742217975 551.925898455028 485.083585980923 0.878892596522083 -0.18624122068171 0.275601486073846 1 8.57473 9.02777 7.92082 8.12591 GeneID:55687,Genbank:NM_018006.4,HGNC:HGNC:25481,MIM:610230 tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase GO:0000049,GO:0002143,GO:0005524,GO:0005654,GO:0005739,GO:0016783,GO:0070903 tRNA binding|tRNA wobble position uridine thiolation|ATP binding|nucleoplasm|mitochondrion|sulfurtransferase activity|mitochondrial tRNA thio-modification TRNAU1AP 684.41386985173 681.16742740026 687.6603123032 1.00953199557372 0.0136866354084066 0.938151562398408 1 6.22577 6.20339 6.64419 6.96347 GeneID:54952,Genbank:NM_017846.4,HGNC:HGNC:30813 tRNA selenocysteine 1 associated protein 1 GO:0001514,GO:0003723,GO:0005634,GO:0005737 selenocysteine incorporation|RNA binding|nucleus|cytoplasm TRNP1 176.171162320722 171.07989455524 181.262430086204 1.05951918287906 0.083409708327314 0.743740249547015 1 4.61077 4.69499 5.31408 4.7352 GeneID:388610,Genbank:XM_005245867.3,HGNC:HGNC:34348,MIM:616824 TMF1-regulated nuclear protein 1 TRNT1 354.168322397164 400.572304491067 307.764340303261 0.768311580338237 -0.380236596117407 0.067317874041544 0.915248786629345 2.37454 1.93692 2.02883 1.4299 GeneID:51095,Genbank:NM_182916.2,HGNC:HGNC:17341,MIM:612907 tRNA nucleotidyl transferase 1 GO:0000049,GO:0001680,GO:0005524,GO:0005622,GO:0005654,GO:0005739,GO:0005759,GO:0034062,GO:0042780,GO:0052927,GO:0052928,GO:0052929,GO:1990180 tRNA binding|tRNA 3'-terminal CCA addition|ATP binding|intracellular|nucleoplasm|mitochondrion|mitochondrial matrix|5'-3' RNA polymerase activity|tRNA 3'-end processing|CTP:tRNA cytidylyltransferase activity|CTP:3'-cytidine-tRNA cytidylyltransferase activity|ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity|mitochondrial tRNA 3'-end processing hsa03013 RNA transport TRO 342.685797083598 363.607260937018 321.764333230177 0.884922738894126 -0.176376593454475 0.355099754402788 1 2.1366 2.32004 1.78465 2.17098 GeneID:7216,Genbank:NM_001039705.2,HGNC:HGNC:12326,MIM:300132 trophinin GO:0005886,GO:0005887,GO:0007156,GO:0007566 plasma membrane|integral component of plasma membrane|homophilic cell adhesion via plasma membrane adhesion molecules|embryo implantation TROAP 1196.06062014603 1206.80297493897 1185.31826535309 0.982197003129726 -0.025915674284988 0.857133694453152 1 10.3478 10.2546 9.86204 10.7715 GeneID:10024,Genbank:NM_005480.3,HGNC:HGNC:12327,MIM:603872 trophinin associated protein GO:0005737,GO:0007155 cytoplasm|cell adhesion TROVE2 321.381076539544 349.509843138986 293.252309940102 0.839038773003849 -0.253190613986412 0.413895083699735 1 1.61286 1.45485 1.62429 1.00997 GeneID:6738,Genbank:NM_001173524.1,HGNC:HGNC:11313,MIM:600063 TROVE domain family member 2 GO:0002520,GO:0003723,GO:0005654,GO:0005829,GO:0006383,GO:0007224,GO:0009411,GO:0030529,GO:0030620,GO:0046872,GO:0060271 immune system development|RNA binding|nucleoplasm|cytosol|transcription from RNA polymerase III promoter|smoothened signaling pathway|response to UV|intracellular ribonucleoprotein complex|U2 snRNA binding|metal ion binding|cilium assembly hsa05322 Systemic lupus erythematosus TRPC1 161.280131171488 160.67272525455 161.887537088426 1.00756078439543 0.0108668766694752 0.955257009942124 1 0.905154 0.694587 0.964127 0.652164 GeneID:7220,Genbank:NM_001251845.1,HGNC:HGNC:12333,MIM:602343 transient receptor potential cation channel subfamily C member 1 GO:0005261,GO:0005737,GO:0005886,GO:0005887,GO:0006828,GO:0015279,GO:0016323,GO:0030017,GO:0042438,GO:0043034,GO:0043234,GO:0043235,GO:0044325,GO:0045121,GO:0046541,GO:0051281,GO:0051480,GO:0051592,GO:0070679 cation channel activity|cytoplasm|plasma membrane|integral component of plasma membrane|manganese ion transport|store-operated calcium channel activity|basolateral plasma membrane|sarcomere|melanin biosynthetic process|costamere|protein complex|receptor complex|ion channel binding|membrane raft|saliva secretion|positive regulation of release of sequestered calcium ion into cytosol|regulation of cytosolic calcium ion concentration|response to calcium ion|inositol 1,4,5 trisphosphate binding hsa04360,hsa04724,hsa04726,hsa04972 Axon guidance|Glutamatergic synapse|Serotonergic synapse|Pancreatic secretion TRPC3 44.3430425958378 47.007619967475 41.6784652242006 0.88663210885891 -0.173592485088085 0.695056221727968 1 0.210282 0.274018 0.264206 0.206968 GeneID:7222,Genbank:XM_017008579.2,HGNC:HGNC:12335,MIM:602345 transient receptor potential cation channel subfamily C member 3 GO:0005262,GO:0005886,GO:0005887,GO:0006816,GO:0006828,GO:0007338,GO:0007602,GO:0010524,GO:0015279,GO:0030168,GO:0033198,GO:0051592,GO:0070588,GO:0070679,GO:1903244 calcium channel activity|plasma membrane|integral component of plasma membrane|calcium ion transport|manganese ion transport|single fertilization|phototransduction|positive regulation of calcium ion transport into cytosol|store-operated calcium channel activity|platelet activation|response to ATP|response to calcium ion|calcium ion transmembrane transport|inositol 1,4,5 trisphosphate binding|positive regulation of cardiac muscle hypertrophy in response to stress hsa04360 Axon guidance TRPC4 4.77593823740381 5.18887166768327 4.36300480712434 0.840838834827521 -0.25009879200112 0.947539733406602 1 0.0317723 0.0154007 0.0306681 0.0142735 GeneID:7223,Genbank:NM_001135958.2,HGNC:HGNC:12336,MIM:603651 transient receptor potential cation channel subfamily C member 4 GO:0005262,GO:0005886,GO:0005887,GO:0005901,GO:0006816,GO:0006828,GO:0008013,GO:0009986,GO:0014051,GO:0015279,GO:0016323,GO:0030863,GO:0034704,GO:0043234,GO:0045296,GO:0048709,GO:0051480,GO:0070509,GO:0070588,GO:0070679 calcium channel activity|plasma membrane|integral component of plasma membrane|caveola|calcium ion transport|manganese ion transport|beta-catenin binding|cell surface|gamma-aminobutyric acid secretion|store-operated calcium channel activity|basolateral plasma membrane|cortical cytoskeleton|calcium channel complex|protein complex|cadherin binding|oligodendrocyte differentiation|regulation of cytosolic calcium ion concentration|calcium ion import|calcium ion transmembrane transport|inositol 1,4,5 trisphosphate binding hsa04360 Axon guidance TRPC4AP 3150.63774969256 3016.09544662884 3285.18005275628 1.08921621045786 0.12329035882481 0.374551717934301 1 26.8894 29.447 29.7977 31.4019 GeneID:26133,Genbank:XM_017027800.2,HGNC:HGNC:16181,MIM:608430 transient receptor potential cation channel subfamily C member 4 associated protein GO:0005262,GO:0005886,GO:0006511,GO:0016567,GO:0019902,GO:0031464,GO:0048820,GO:0070588 calcium channel activity|plasma membrane|ubiquitin-dependent protein catabolic process|protein ubiquitination|phosphatase binding|Cul4A-RING E3 ubiquitin ligase complex|hair follicle maturation|calcium ion transmembrane transport TRPC5OS 1.48541773607917 1.51824048055703 1.45259499160132 0.956762127083039 -0.0637678125324669 1 1 0.014141 0.0137044 0 0.0380697 GeneID:100329135,Genbank:NM_001195576.1,HGNC:HGNC:40593 TRPC5 opposite strand TRPC6 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0158002 GeneID:7225,Genbank:XM_017018221.2,HGNC:HGNC:12338,MIM:603652 transient receptor potential cation channel subfamily C member 6 GO:0003779,GO:0005261,GO:0005262,GO:0005737,GO:0005886,GO:0005887,GO:0006812,GO:0006828,GO:0007204,GO:0007338,GO:0007568,GO:0010800,GO:0015279,GO:0016020,GO:0030168,GO:0030182,GO:0030276,GO:0032414,GO:0036057,GO:0042803,GO:0042805,GO:0045666,GO:0050774,GO:0051117,GO:0051480,GO:0051928,GO:0070301,GO:0070588,GO:0070679,GO:0071456 actin binding|cation channel activity|calcium channel activity|cytoplasm|plasma membrane|integral component of plasma membrane|cation transport|manganese ion transport|positive regulation of cytosolic calcium ion concentration|single fertilization|aging|positive regulation of peptidyl-threonine phosphorylation|store-operated calcium channel activity|membrane|platelet activation|neuron differentiation|clathrin binding|positive regulation of ion transmembrane transporter activity|slit diaphragm|protein homodimerization activity|actinin binding|positive regulation of neuron differentiation|negative regulation of dendrite morphogenesis|ATPase binding|regulation of cytosolic calcium ion concentration|positive regulation of calcium ion transport|cellular response to hydrogen peroxide|calcium ion transmembrane transport|inositol 1,4,5 trisphosphate binding|cellular response to hypoxia hsa04022,hsa04360 cGMP-PKG signaling pathway|Axon guidance TRPM1 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0 GeneID:4308,Genbank:NM_001252020.1,HGNC:HGNC:7146,MIM:603576 transient receptor potential cation channel subfamily M member 1 GO:0005261,GO:0005262,GO:0005886,GO:0007165,GO:0007216,GO:0007601,GO:0016021,GO:0035841,GO:0046548,GO:0051262,GO:0060402,GO:0071482 cation channel activity|calcium channel activity|plasma membrane|signal transduction|G-protein coupled glutamate receptor signaling pathway|visual perception|integral component of membrane|new growing cell tip|retinal rod cell development|protein tetramerization|calcium ion transport into cytosol|cellular response to light stimulus TRPM2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:7226,Genbank:XM_017028456.1,HGNC:HGNC:12339,MIM:603749 transient receptor potential cation channel subfamily M member 2 hsa04621,hsa04921 NOD-like receptor signaling pathway|Oxytocin signaling pathway TRPM3 32.5305081205783 26.2903509163189 38.7706653248377 1.47471083395741 0.560432093922749 0.260198486196192 1 0.0536086 0.0391677 0.0740166 0.0742661 GeneID:80036,Genbank:XM_011519045.2,HGNC:HGNC:17992,MIM:608961 transient receptor potential cation channel subfamily M member 3 GO:0005227,GO:0005261,GO:0005262,GO:0005886,GO:0006812,GO:0016021,GO:0016048,GO:0050951,GO:0051262,GO:0070588 calcium activated cation channel activity|cation channel activity|calcium channel activity|plasma membrane|cation transport|integral component of membrane|detection of temperature stimulus|sensory perception of temperature stimulus|protein tetramerization|calcium ion transmembrane transport TRPM4 163.761721392212 137.554142469146 189.969300315278 1.38105110398902 0.465766705625954 0.0631375194099708 0.894697583479674 1.20295 1.73089 2.06901 2.15025 GeneID:54795,Genbank:NM_001321282.1,HGNC:HGNC:17993,MIM:606936 transient receptor potential cation channel subfamily M member 4 GO:0002250,GO:0002407,GO:0002724,GO:0005227,GO:0005262,GO:0005272,GO:0005516,GO:0005524,GO:0005654,GO:0005783,GO:0005794,GO:0005829,GO:0005886,GO:0007204,GO:0008284,GO:0010460,GO:0016925,GO:0019722,GO:0030502,GO:0034706,GO:0035774,GO:0042310,GO:0043025,GO:0045600,GO:0045668,GO:0045907,GO:0070588,GO:0086045,GO:0086047,GO:0086048,GO:0086091,GO:0090263,GO:0098719,GO:0098911,GO:1903949,GO:1904179,GO:1904199 adaptive immune response|dendritic cell chemotaxis|regulation of T cell cytokine production|calcium activated cation channel activity|calcium channel activity|sodium channel activity|calmodulin binding|ATP binding|nucleoplasm|endoplasmic reticulum|Golgi apparatus|cytosol|plasma membrane|positive regulation of cytosolic calcium ion concentration|positive regulation of cell proliferation|positive regulation of heart rate|protein sumoylation|calcium-mediated signaling|negative regulation of bone mineralization|sodium channel complex|positive regulation of insulin secretion involved in cellular response to glucose stimulus|vasoconstriction|neuronal cell body|positive regulation of fat cell differentiation|negative regulation of osteoblast differentiation|positive regulation of vasoconstriction|calcium ion transmembrane transport|membrane depolarization during AV node cell action potential|membrane depolarization during Purkinje myocyte cell action potential|membrane depolarization during bundle of His cell action potential|regulation of heart rate by cardiac conduction|positive regulation of canonical Wnt signaling pathway|sodium ion import across plasma membrane|regulation of ventricular cardiac muscle cell action potential|positive regulation of atrial cardiac muscle cell action potential|positive regulation of adipose tissue development|positive regulation of regulation of vascular smooth muscle cell membrane depolarization hsa04911 Insulin secretion TRPM6 3.87620946662518 4.84287908978074 2.90953984346962 0.600787215524175 -0.73507398159595 0.827780198438178 1 0.0190516 0 0.0182989 0 GeneID:140803,Genbank:NM_017662.4,HGNC:HGNC:17995,MIM:607009 transient receptor potential cation channel subfamily M member 6 GO:0004674,GO:0005262,GO:0005524,GO:0005886,GO:0009636,GO:0016021,GO:0016324,GO:0031526,GO:0046872,GO:0051262,GO:0070588 protein serine/threonine kinase activity|calcium channel activity|ATP binding|plasma membrane|response to toxic substance|integral component of membrane|apical plasma membrane|brush border membrane|metal ion binding|protein tetramerization|calcium ion transmembrane transport hsa04978 Mineral absorption TRPM7 467.502263921901 492.915416466297 442.089111377504 0.896886355364648 -0.157002902316698 0.695856099105229 1 1.71151 1.49136 1.91055 1.03377 GeneID:54822,Genbank:NM_001301212.1,HGNC:HGNC:17994,MIM:605692 transient receptor potential cation channel subfamily M member 7 GO:0001726,GO:0003779,GO:0004674,GO:0005262,GO:0005524,GO:0005886,GO:0010961,GO:0016021,GO:0016340,GO:0017022,GO:0031032,GO:0046777,GO:0046872,GO:0051262,GO:0070266,GO:0070588 ruffle|actin binding|protein serine/threonine kinase activity|calcium channel activity|ATP binding|plasma membrane|cellular magnesium ion homeostasis|integral component of membrane|calcium-dependent cell-matrix adhesion|myosin binding|actomyosin structure organization|protein autophosphorylation|metal ion binding|protein tetramerization|necroptotic process|calcium ion transmembrane transport hsa04217,hsa04218,hsa04621,hsa04978 Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Mineral absorption TRPM8 37.8997852659879 43.8172515271982 31.9823190047775 0.72990244458682 -0.454224442012379 0.340996542661215 1 0.18094 0.126076 0.102062 0.119623 GeneID:79054,Genbank:XM_011511810.2,HGNC:HGNC:17961,MIM:606678 transient receptor potential cation channel subfamily M member 8 GO:0005262,GO:0005789,GO:0005886,GO:0006874,GO:0009409,GO:0009897,GO:0016021,GO:0016048,GO:0042803,GO:0045121,GO:0050955,GO:0051289,GO:0070207,GO:0070588 calcium channel activity|endoplasmic reticulum membrane|plasma membrane|cellular calcium ion homeostasis|response to cold|external side of plasma membrane|integral component of membrane|detection of temperature stimulus|protein homodimerization activity|membrane raft|thermoception|protein homotetramerization|protein homotrimerization|calcium ion transmembrane transport hsa04750 Inflammatory mediator regulation of TRP channels TRPS1 362.637069216264 344.282753851725 380.991384580802 1.10662349571215 0.146164460365948 0.647717642717289 1 1.32296 1.17481 1.74683 1.0552 GeneID:7227,Genbank:NM_001330599.1,HGNC:HGNC:12340,MIM:604386 transcriptional repressor GATA binding 1 GO:0000122,GO:0000790,GO:0000977,GO:0001085,GO:0001227,GO:0001228,GO:0001501,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0005667,GO:0006366,GO:0006607,GO:0008270,GO:0019904,GO:0030154,GO:0032330,GO:0043234,GO:0051291 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|skeletal system development|chromatin binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription factor complex|transcription from RNA polymerase II promoter|NLS-bearing protein import into nucleus|zinc ion binding|protein domain specific binding|cell differentiation|regulation of chondrocyte differentiation|protein complex|protein heterooligomerization TRPT1 341.279134824427 322.058069975975 360.500199672879 1.11936396967097 0.162679215814235 0.659703621391331 1 6.53996 6.36818 5.14961 7.98416 GeneID:83707,Genbank:NM_001160390.1,HGNC:HGNC:20316,MIM:610470 tRNA phosphotransferase 1 GO:0000215,GO:0006388,GO:0045859 tRNA 2'-phosphotransferase activity|tRNA splicing, via endonucleolytic cleavage and ligation|regulation of protein kinase activity TRPV1 70.5517690862978 63.5543777744395 77.549160398156 1.22020170936745 0.287119656845565 0.416972237026894 1 0.449445 0.467724 0.67914 0.42338 GeneID:7442,Genbank:NM_080704.3,HGNC:HGNC:12716,MIM:602076 transient receptor potential cation channel subfamily V member 1 hsa04080,hsa04750 Neuroactive ligand-receptor interaction|Inflammatory mediator regulation of TRP channels TRPV2 44.4386103258114 32.1712077398073 56.7060129118154 1.76263239386098 0.817731624486304 0.0593837819913705 0.879410748501007 0.249989 0.259996 0.548354 0.434174 GeneID:51393,Genbank:NM_016113.4,HGNC:HGNC:18082,MIM:606676 transient receptor potential cation channel subfamily V member 2 hsa04621,hsa04750 NOD-like receptor signaling pathway|Inflammatory mediator regulation of TRP channels TRPV3 6.55148141343481 6.80316469761019 6.29979812925943 0.92600993938489 -0.110900416062399 1 1 0.0547987 0.0185191 0.0386746 0.0480604 GeneID:162514,Genbank:NM_145068.3,HGNC:HGNC:18084,MIM:607066 transient receptor potential cation channel subfamily V member 3 hsa04750 Inflammatory mediator regulation of TRP channels TRPV4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:59341,Genbank:NM_021625.4,HGNC:HGNC:18083,MIM:605427 transient receptor potential cation channel subfamily V member 4 GO:0000122,GO:0002024,GO:0003779,GO:0005034,GO:0005080,GO:0005261,GO:0005262,GO:0005516,GO:0005524,GO:0005881,GO:0005886,GO:0005887,GO:0005912,GO:0005925,GO:0005929,GO:0006816,GO:0006874,GO:0006884,GO:0007015,GO:0007043,GO:0007204,GO:0007231,GO:0008017,GO:0009612,GO:0009986,GO:0010628,GO:0010759,GO:0010977,GO:0015275,GO:0016021,GO:0016324,GO:0019901,GO:0030027,GO:0030103,GO:0030175,GO:0030426,GO:0030864,GO:0031117,GO:0031410,GO:0031532,GO:0032587,GO:0032868,GO:0034605,GO:0042169,GO:0042538,GO:0042593,GO:0042802,GO:0043014,GO:0043117,GO:0043622,GO:0046330,GO:0046785,GO:0047484,GO:0048487,GO:0050729,GO:0050891,GO:0051015,GO:0060351,GO:0070374,GO:0070509,GO:0070588,GO:0071470,GO:0071476,GO:0071477,GO:0071639,GO:0071642,GO:0071651,GO:0097497,GO:1903444,GO:1903759,GO:2000340,GO:2000507,GO:2000778 negative regulation of transcription from RNA polymerase II promoter|diet induced thermogenesis|actin binding|osmosensor activity|protein kinase C binding|cation channel activity|calcium channel activity|calmodulin binding|ATP binding|cytoplasmic microtubule|plasma membrane|integral component of plasma membrane|adherens junction|focal adhesion|cilium|calcium ion transport|cellular calcium ion homeostasis|cell volume homeostasis|actin filament organization|cell-cell junction assembly|positive regulation of cytosolic calcium ion concentration|osmosensory signaling pathway|microtubule binding|response to mechanical stimulus|cell surface|positive regulation of gene expression|positive regulation of macrophage chemotaxis|negative regulation of neuron projection development|stretch-activated, cation-selective, calcium channel activity|integral component of membrane|apical plasma membrane|protein kinase binding|lamellipodium|vasopressin secretion|filopodium|growth cone|cortical actin cytoskeleton|positive regulation of microtubule depolymerization|cytoplasmic vesicle|actin cytoskeleton reorganization|ruffle membrane|response to insulin|cellular response to heat|SH2 domain binding|hyperosmotic salinity response|glucose homeostasis|identical protein binding|alpha-tubulin binding|positive regulation of vascular permeability|cortical microtubule organization|positive regulation of JNK cascade|microtubule polymerization|regulation of response to osmotic stress|beta-tubulin binding|positive regulation of inflammatory response|multicellular organismal water homeostasis|actin filament binding|cartilage development involved in endochondral bone morphogenesis|positive regulation of ERK1 and ERK2 cascade|calcium ion import|calcium ion transmembrane transport|cellular response to osmotic stress|cellular hypotonic response|cellular hypotonic salinity response|positive regulation of monocyte chemotactic protein-1 production|positive regulation of macrophage inflammatory protein 1 alpha production|positive regulation of chemokine (C-C motif) ligand 5 production|blood vessel endothelial cell delamination|negative regulation of brown fat cell differentiation|signal transduction involved in regulation of aerobic respiration|positive regulation of chemokine (C-X-C motif) ligand 1 production|positive regulation of energy homeostasis|positive regulation of interleukin-6 secretion hsa04218,hsa04750,hsa05418 Cellular senescence|Inflammatory mediator regulation of TRP channels|Fluid shear stress and atherosclerosis TRRAP 4134.57163801339 4172.2181364115 4096.92513961529 0.981953724773133 -0.0262730567153894 0.842064859181704 1 11.3419 11.4124 12.8325 10.0385 GeneID:8295,Genbank:NM_001244580.1,HGNC:HGNC:12347,MIM:603015 transformation/transcription domain associated protein GO:0000125,GO:0000812,GO:0003712,GO:0005634,GO:0005654,GO:0005794,GO:0006281,GO:0006351,GO:0006355,GO:0016301,GO:0016573,GO:0016578,GO:0016579,GO:0030914,GO:0033276,GO:0035267,GO:0036459,GO:0043967,GO:0043968,GO:1904837 PCAF complex|Swr1 complex|transcription cofactor activity|nucleus|nucleoplasm|Golgi apparatus|DNA repair|transcription, DNA-templated|regulation of transcription, DNA-templated|kinase activity|histone acetylation|histone deubiquitination|protein deubiquitination|STAGA complex|transcription factor TFTC complex|NuA4 histone acetyltransferase complex|thiol-dependent ubiquitinyl hydrolase activity|histone H4 acetylation|histone H2A acetylation|beta-catenin-TCF complex assembly hsa05166 Human T-cell leukemia virus 1 infection TRUB1 725.440294764697 763.121970384161 687.758619145234 0.901243373715228 -0.1500113477387 0.449052975242284 1 11.2944 10.3303 11.1905 8.37587 GeneID:142940,Genbank:NM_139169.4,HGNC:HGNC:16060,MIM:610726 TruB pseudouridine synthase family member 1 GO:0003723,GO:0005739,GO:0006400,GO:0009982,GO:1990481 RNA binding|mitochondrion|tRNA modification|pseudouridine synthase activity|mRNA pseudouridine synthesis TRUB2 1019.42696945076 1102.15125998587 936.702678915651 0.849885776048255 -0.234659137639469 0.159891923642333 1 12.9307 14.2513 10.3256 12.8988 GeneID:26995,Genbank:NM_001329861.1,HGNC:HGNC:17170,MIM:610727 TruB pseudouridine synthase family member 2 GO:0001522,GO:0003723,GO:0005759,GO:0005829,GO:0006397,GO:0009982 pseudouridine synthesis|RNA binding|mitochondrial matrix|cytosol|mRNA processing|pseudouridine synthase activity TSACC 5.42519322180686 4.06465003971372 6.7857364039 1.66945157334576 0.739374244998988 0.619197353801565 1 0.0835727 0.0756456 0.196397 0.0733026 GeneID:128229,Genbank:NM_144627.4,HGNC:HGNC:30636 TSSK6 activating cochaperone GO:0005737,GO:0051087 cytoplasm|chaperone binding TSC1 388.891541654824 401.179062753464 376.604020556183 0.938742959244651 -0.0911979127141606 0.663650452047435 1 1.20378 1.45323 1.48633 1.10733 GeneID:7248,Genbank:NM_001162427.1,HGNC:HGNC:12362,MIM:605284 TSC complex subunit 1 hsa04072,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04714,hsa04910,hsa05163,hsa05165,hsa05231 Phospholipase D signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Thermogenesis|Insulin signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Choline metabolism in cancer TSC2 1496.02055181368 1445.07067783705 1546.97042579031 1.07051540766558 0.0983055602285651 0.518969816945907 1 7.34511 7.91632 9.01752 8.18634 GeneID:7249,Genbank:XM_011522638.2,HGNC:HGNC:12363,MIM:191092 TSC complex subunit 2 hsa04072,hsa04115,hsa04140,hsa04150,hsa04151,hsa04152,hsa04211,hsa04218,hsa04714,hsa04910,hsa04919,hsa05163,hsa05165,hsa05231 Phospholipase D signaling pathway|p53 signaling pathway|Autophagy - animal|mTOR signaling pathway|PI3K-Akt signaling pathway|AMPK signaling pathway|Longevity regulating pathway|Cellular senescence|Thermogenesis|Insulin signaling pathway|Thyroid hormone signaling pathway|Human cytomegalovirus infection|Human papillomavirus infection|Choline metabolism in cancer TSC22D1 2214.7246201357 1918.44005615399 2511.00918411741 1.30888071069126 0.388333618340227 0.00533347242598216 0.285941071095182 8.20547 8.37297 12.0341 9.93402 GeneID:8848,Genbank:NM_001243799.1,HGNC:HGNC:16826,MIM:607715 TSC22 domain family member 1 GO:0003700,GO:0005634,GO:0005737,GO:0006351 DNA binding transcription factor activity|nucleus|cytoplasm|transcription, DNA-templated TSC22D2 483.073436562683 447.523106529603 518.623766595763 1.15887595305977 0.212726147463216 0.345801462476407 1 4.37078 4.34382 6.03953 4.17426 GeneID:9819,Genbank:NM_014779.3,HGNC:HGNC:29095,MIM:617724 TSC22 domain family member 2 GO:0003700,GO:0005634,GO:0005737,GO:0006970 DNA binding transcription factor activity|nucleus|cytoplasm|response to osmotic stress TSC22D3 405.238517510413 399.55496106843 410.922073952396 1.02844943497528 0.0404708636696388 0.863203726563329 1 4.36888 4.81506 4.22924 5.15573 GeneID:1831,Genbank:XM_005262099.1,HGNC:HGNC:3051,MIM:300506 TSC22 domain family member 3 GO:0000122,GO:0003700,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006970,GO:0034220,GO:0043426,GO:0048642,GO:0070236 negative regulation of transcription from RNA polymerase II promoter|DNA binding transcription factor activity|nucleus|cytoplasm|cytosol|regulation of transcription, DNA-templated|response to osmotic stress|ion transmembrane transport|MRF binding|negative regulation of skeletal muscle tissue development|negative regulation of activation-induced cell death of T cells TSC22D4 1882.44383266742 1862.70146284897 1902.18620248588 1.02119756730986 0.0302620060831046 0.870133123502916 1 28.9649 32.3954 32.4622 30.991 GeneID:81628,Genbank:NM_001303043.1,HGNC:HGNC:21696,MIM:611914 TSC22 domain family member 4 GO:0003700,GO:0005634,GO:0005737,GO:0006351,GO:0045892,GO:0070236 DNA binding transcription factor activity|nucleus|cytoplasm|transcription, DNA-templated|negative regulation of transcription, DNA-templated|negative regulation of activation-induced cell death of T cells TSEN15 872.045924909381 891.635330555721 852.456519263042 0.956059602003141 -0.0648275343863432 0.669433611830273 1 9.24386 10.7763 10.2626 9.65464 GeneID:116461,Genbank:NM_001300764.1,HGNC:HGNC:16791,MIM:608756 tRNA splicing endonuclease subunit 15 GO:0000213,GO:0005654,GO:0005730,GO:0006388,GO:0006397 tRNA-intron endonuclease activity|nucleoplasm|nucleolus|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing TSEN2 380.167991900089 401.207471717933 359.128512082244 0.895119202402908 -0.159848277019647 0.389753413448731 1 2.75852 2.79286 2.60258 2.24267 GeneID:80746,Genbank:NM_001321278.1,HGNC:HGNC:28422,MIM:608753 tRNA splicing endonuclease subunit 2 GO:0000213,GO:0000214,GO:0000379,GO:0005654,GO:0005730,GO:0005813,GO:0005829,GO:0006388,GO:0006397,GO:0016829 tRNA-intron endonuclease activity|tRNA-intron endonuclease complex|tRNA-type intron splice site recognition and cleavage|nucleoplasm|nucleolus|centrosome|cytosol|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing|lyase activity TSEN34 1862.22369515369 1896.99563533002 1827.45175497737 0.963339989266475 -0.0538830400555175 0.686283834145123 1 29.4605 33.963 30.0087 32.0072 GeneID:79042,Genbank:XM_011527294.3,HGNC:HGNC:15506,MIM:608754 tRNA splicing endonuclease subunit 34 GO:0000213,GO:0000214,GO:0000379,GO:0005634,GO:0005654,GO:0005730,GO:0006388,GO:0006397,GO:0016829 tRNA-intron endonuclease activity|tRNA-intron endonuclease complex|tRNA-type intron splice site recognition and cleavage|nucleus|nucleoplasm|nucleolus|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing|lyase activity TSEN54 411.890158434225 427.353743810198 396.426573058252 0.927630982061359 -0.108377089349501 0.551656766649324 1 8.33604 8.23919 7.80086 7.63459 GeneID:283989,Genbank:XM_005257229.4,HGNC:HGNC:27561,MIM:608755 tRNA splicing endonuclease subunit 54 GO:0000214,GO:0000379,GO:0005654,GO:0005730,GO:0006388,GO:0006397,GO:0090502 tRNA-intron endonuclease complex|tRNA-type intron splice site recognition and cleavage|nucleoplasm|nucleolus|tRNA splicing, via endonucleolytic cleavage and ligation|mRNA processing|RNA phosphodiester bond hydrolysis, endonucleolytic TSFM 570.912809518542 609.243618172969 532.582000864116 0.874169191072121 -0.19401556173142 0.251749344133712 1 9.14142 9.29261 8.25201 8.60574 GeneID:10102,Genbank:NM_001172697.1,HGNC:HGNC:12367,MIM:604723 Ts translation elongation factor, mitochondrial GO:0003723,GO:0003746,GO:0005634,GO:0005739,GO:0005759,GO:0006414,GO:0032784,GO:0070125,GO:0070129 RNA binding|translation elongation factor activity|nucleus|mitochondrion|mitochondrial matrix|translational elongation|regulation of DNA-templated transcription, elongation|mitochondrial translational elongation|regulation of mitochondrial translation TSG101 1456.58324448326 1460.30888357071 1452.85760539581 0.994897464325028 -0.00738024795707028 0.961895011470335 1 26.8535 26.8782 26.5025 27.4661 GeneID:7251,Genbank:NM_006292.3,HGNC:HGNC:15971,MIM:601387 tumor susceptibility 101 GO:0000813,GO:0001558,GO:0003677,GO:0003714,GO:0005730,GO:0005737,GO:0005768,GO:0005769,GO:0005770,GO:0005771,GO:0005815,GO:0005829,GO:0005886,GO:0006513,GO:0006858,GO:0007050,GO:0007175,GO:0008285,GO:0008333,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0030216,GO:0030374,GO:0031625,GO:0031901,GO:0031902,GO:0032403,GO:0036258,GO:0039702,GO:0042059,GO:0042803,GO:0043130,GO:0043162,GO:0043405,GO:0043657,GO:0045892,GO:0046755,GO:0046790,GO:0048306,GO:0048524,GO:0051301,GO:0070062,GO:0075733,GO:0090543,GO:0097352,GO:1902188,GO:1903543,GO:1903551,GO:1903772,GO:1903774,GO:1990182,GO:2000397 ESCRT I complex|regulation of cell growth|DNA binding|transcription corepressor activity|nucleolus|cytoplasm|endosome|early endosome|late endosome|multivesicular body|microtubule organizing center|cytosol|plasma membrane|protein monoubiquitination|extracellular transport|cell cycle arrest|negative regulation of epidermal growth factor-activated receptor activity|negative regulation of cell proliferation|endosome to lysosome transport|endosome membrane|protein transport|endosomal transport|macroautophagy|viral life cycle|keratinocyte differentiation|ligand-dependent nuclear receptor transcription coactivator activity|ubiquitin protein ligase binding|early endosome membrane|late endosome membrane|protein complex binding|multivesicular body assembly|viral budding via host ESCRT complex|negative regulation of epidermal growth factor receptor signaling pathway|protein homodimerization activity|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|regulation of MAP kinase activity|host cell|negative regulation of transcription, DNA-templated|viral budding|virion binding|calcium-dependent protein binding|positive regulation of viral process|cell division|extracellular exosome|intracellular transport of virus|Flemming body|autophagosome maturation|positive regulation of viral release from host cell|positive regulation of exosomal secretion|regulation of extracellular exosome assembly|regulation of viral budding via host ESCRT complex|positive regulation of viral budding via host ESCRT complex|exosomal secretion|positive regulation of ubiquitin-dependent endocytosis hsa04144 Endocytosis TSGA10 28.877486553064 23.3499225045747 34.4050506015532 1.47345459475562 0.559202603773625 0.282523072891672 1 0.0830632 0.0612346 0.0895443 0.113952 GeneID:80705,Genbank:NM_001349013.1,HGNC:HGNC:14927,MIM:607166 testis specific 10 GO:0005737,GO:0007283,GO:0030031,GO:0031514,GO:0031965,GO:0043005 cytoplasm|spermatogenesis|cell projection assembly|motile cilium|nuclear membrane|neuron projection TSGA10IP 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0 0.0151939 0 0 GeneID:254187,Genbank:XM_011544887.2,HGNC:HGNC:26555 testis specific 10 interacting protein TSGA13 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0303676 0.0141562 GeneID:114960,Genbank:NM_001304968.1,HGNC:HGNC:12369 testis specific 13 GO:1903955 positive regulation of protein targeting to mitochondrion TSHR 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00712359 GeneID:7253,Genbank:XM_005268037.4,HGNC:HGNC:12373,MIM:603372 thyroid stimulating hormone receptor hsa04024,hsa04080,hsa04918,hsa04923,hsa05320 cAMP signaling pathway|Neuroactive ligand-receptor interaction|Thyroid hormone synthesis|Regulation of lipolysis in adipocytes|Autoimmune thyroid disease TSHZ1 253.113685941048 270.22617122808 236.001200654015 0.87334694334555 -0.19537320619797 0.355459943479389 1 1.72931 1.75269 1.47512 1.60572 GeneID:10194,Genbank:NM_005786.5,HGNC:HGNC:10669,MIM:614427 teashirt zinc finger homeobox 1 GO:0001078,GO:0003677,GO:0003682,GO:0005634,GO:0006351,GO:0006357,GO:0007275,GO:0009952,GO:0042474,GO:0046872,GO:0060023 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|chromatin binding|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|multicellular organism development|anterior/posterior pattern specification|middle ear morphogenesis|metal ion binding|soft palate development TSHZ2 258.970007256983 230.021715958216 287.91829855575 1.25170050730363 0.323889411859262 0.266730359147946 1 0.652766 0.634197 0.978233 0.633194 GeneID:128553,Genbank:XM_017027641.1,HGNC:HGNC:13010,MIM:614118 teashirt zinc finger homeobox 2 GO:0001078,GO:0003677,GO:0003682,GO:0005634,GO:0006351,GO:0006357,GO:0007275,GO:0046872 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|chromatin binding|nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|multicellular organism development|metal ion binding TSHZ3 169.159475004652 165.285281626014 173.03366838329 1.04687886713838 0.066094519738788 0.778774945259063 1 1.32306 1.08378 1.49282 1.06257 GeneID:57616,Genbank:NM_020856.3,HGNC:HGNC:30700,MIM:614119 teashirt zinc finger homeobox 3 TSKS 0.484633316560471 0 0.969266633120943 Inf Inf 0.786368128793178 1 0 0 0.0220705 0 GeneID:60385,Genbank:XM_011527201.1,HGNC:HGNC:30719,MIM:608253 testis specific serine kinase substrate GO:0001669,GO:0005814,GO:0010923,GO:0019901 acrosomal vesicle|centriole|negative regulation of phosphatase activity|protein kinase binding TSKU 787.966259764526 744.289568702535 831.642950826517 1.11736478085573 0.160100252623535 0.317664095637406 1 7.96108 7.99392 9.46923 8.75518 GeneID:25987,Genbank:NM_001258210.1,HGNC:HGNC:28850,MIM:608015 tsukushi, small leucine rich proteoglycan GO:0004930,GO:0005615,GO:0005886,GO:0007188,GO:0010468,GO:0021540,GO:0021670,GO:0021960,GO:0030178,GO:0061073 G-protein coupled receptor activity|extracellular space|plasma membrane|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|regulation of gene expression|corpus callosum morphogenesis|lateral ventricle development|anterior commissure morphogenesis|negative regulation of Wnt signaling pathway|ciliary body morphogenesis TSLP 18.1218572953989 13.9523219731229 22.2913926176749 1.59768335769601 0.675981511177813 0.31511814162252 1 0.186134 0.180912 0.314481 0.349633 GeneID:85480,Genbank:NM_033035.4,HGNC:HGNC:30743,MIM:607003 thymic stromal lymphopoietin GO:0001961,GO:0005125,GO:0005139,GO:0005576,GO:0005615,GO:0008284,GO:0032722,GO:0032733,GO:0032736,GO:0032754,GO:0032755,GO:0033005,GO:0038111,GO:0042531,GO:0043066,GO:0044140,GO:0050729,GO:0050829,GO:0050832,GO:0061844,GO:0071654,GO:0071657,GO:1904894,GO:2000664 positive regulation of cytokine-mediated signaling pathway|cytokine activity|interleukin-7 receptor binding|extracellular region|extracellular space|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of interleukin-10 production|positive regulation of interleukin-13 production|positive regulation of interleukin-5 production|positive regulation of interleukin-6 production|positive regulation of mast cell activation|interleukin-7-mediated signaling pathway|positive regulation of tyrosine phosphorylation of STAT protein|negative regulation of apoptotic process|negative regulation of growth of symbiont on or near host surface|positive regulation of inflammatory response|defense response to Gram-negative bacterium|defense response to fungus|antimicrobial humoral immune response mediated by antimicrobial peptide|positive regulation of chemokine (C-C motif) ligand 1 production|positive regulation of granulocyte colony-stimulating factor production|positive regulation of STAT cascade|positive regulation of interleukin-5 secretion hsa04060,hsa04630 Cytokine-cytokine receptor interaction|Jak-STAT signaling pathway TSN 1515.31261423849 1581.58379156993 1449.04143690706 0.916196438424992 -0.126271140279192 0.392683418698597 1 22.5935 22.1139 21.0812 20.1889 GeneID:7247,Genbank:NM_004622.2,HGNC:HGNC:12379,MIM:600575 translin GO:0003677,GO:0003697,GO:0003729,GO:0004519,GO:0005634,GO:0005829,GO:0006310,GO:0030422,GO:0042802,GO:0043565 DNA binding|single-stranded DNA binding|mRNA binding|endonuclease activity|nucleus|cytosol|DNA recombination|production of siRNA involved in RNA interference|identical protein binding|sequence-specific DNA binding TSNARE1 78.9513386166314 86.1839061587401 71.7187710745226 0.832159671927906 -0.265067720611133 0.412878656596751 1 0.180992 0.259707 0.158593 0.2087 GeneID:203062,Genbank:NM_145003.4,HGNC:HGNC:26437 t-SNARE domain containing 1 GO:0000149,GO:0005484,GO:0006886,GO:0006906,GO:0012505,GO:0016021,GO:0031201,GO:0048278 SNARE binding|SNAP receptor activity|intracellular protein transport|vesicle fusion|endomembrane system|integral component of membrane|SNARE complex|vesicle docking TSNAX 652.263661178213 722.927323769404 581.599998587022 0.804506870143613 -0.313823353889168 0.0610740340331272 0.882851581387291 12.2872 11.1026 10.6299 8.5598 GeneID:7257,Genbank:NM_005999.2,HGNC:HGNC:12380,MIM:602964 translin associated factor X GO:0003677,GO:0003723,GO:0005634,GO:0005794,GO:0005829,GO:0007275,GO:0007283,GO:0008565,GO:0030154,GO:0030422,GO:0043565,GO:0046872,GO:0048471 DNA binding|RNA binding|nucleus|Golgi apparatus|cytosol|multicellular organism development|spermatogenesis|protein transporter activity|cell differentiation|production of siRNA involved in RNA interference|sequence-specific DNA binding|metal ion binding|perinuclear region of cytoplasm TSNAXIP1 18.8416654078476 22.1776746019202 15.5056562137749 0.699156087917006 -0.516313518935871 0.45412834950798 1 0.172514 0.155225 0.0924027 0.118526 GeneID:55815,Genbank:XM_011523230.2,HGNC:HGNC:18586,MIM:607720 translin associated factor X interacting protein 1 GO:0007275,GO:0007283,GO:0030154,GO:0048471 multicellular organism development|spermatogenesis|cell differentiation|perinuclear region of cytoplasm TSPAN1 20.4118212249402 15.6244499328427 25.1991925170377 1.61280509876183 0.689572104929377 0.29973826554204 1 0.18345 0.402969 0.518152 0.529473 GeneID:10103,Genbank:NM_005727.3,HGNC:HGNC:20657,MIM:613170 tetraspanin 1 TSPAN10 81.8722400754944 76.0462941967983 87.6981859541905 1.15322103306229 0.205669054829553 0.657748088549911 1 1.85548 2.0048 1.75724 2.27081 GeneID:83882,Genbank:NM_001290212.1,HGNC:HGNC:29942 tetraspanin 10 GO:0005887,GO:0007166,GO:0019899,GO:0072594 integral component of plasma membrane|cell surface receptor signaling pathway|enzyme binding|establishment of protein localization to organelle TSPAN11 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:441631,Genbank:XM_011520679.2,HGNC:HGNC:30795 tetraspanin 11 GO:0005887,GO:0007166 integral component of plasma membrane|cell surface receptor signaling pathway TSPAN12 179.265547574265 209.746492034332 148.784603114198 0.709354429106946 -0.495421444362202 0.0378832947812412 0.745170033530679 2.65553 2.64107 2.05376 1.93995 GeneID:23554,Genbank:XM_005250239.3,HGNC:HGNC:21641,MIM:613138 tetraspanin 12 GO:0001525,GO:0005887,GO:0007166,GO:0010842,GO:0016020,GO:0016021,GO:0045765 angiogenesis|integral component of plasma membrane|cell surface receptor signaling pathway|retina layer formation|membrane|integral component of membrane|regulation of angiogenesis TSPAN13 344.5077959064 326.525530522529 362.490061290271 1.1101430896083 0.150745641767945 0.431646095239286 1 10.3814 10.4877 11.3129 11.7119 GeneID:27075,Genbank:NM_014399.3,HGNC:HGNC:21643,MIM:613139 tetraspanin 13 GO:0005246,GO:0005887,GO:0007166,GO:0016020,GO:1903169 calcium channel regulator activity|integral component of plasma membrane|cell surface receptor signaling pathway|membrane|regulation of calcium ion transmembrane transport TSPAN14 2837.83873715694 3153.16932635113 2522.50814796275 0.799991337884099 -0.3219437159615 0.01753897910781 0.545445222117836 21.6824 23.2404 18.796 17.4623 GeneID:81619,Genbank:NM_001351267.1,HGNC:HGNC:23303 tetraspanin 14 GO:0005886,GO:0005887,GO:0019899,GO:0035579,GO:0043312,GO:0045747,GO:0051604,GO:0070821,GO:0072659 plasma membrane|integral component of plasma membrane|enzyme binding|specific granule membrane|neutrophil degranulation|positive regulation of Notch signaling pathway|protein maturation|tertiary granule membrane|protein localization to plasma membrane TSPAN15 1272.52314633386 1427.12033240826 1117.92596025945 0.783343867277789 -0.352282343291846 0.0384941126013391 0.750691665757301 4.05052 4.53406 3.07315 3.66439 GeneID:23555,Genbank:XM_017016010.1,HGNC:HGNC:23298,MIM:613140 tetraspanin 15 GO:0005886,GO:0005887,GO:0007166,GO:0009986,GO:0019899,GO:0031902,GO:0051604,GO:0070062,GO:0072659,GO:0097197 plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|cell surface|enzyme binding|late endosome membrane|protein maturation|extracellular exosome|protein localization to plasma membrane|tetraspanin-enriched microdomain TSPAN17 2348.56979206555 2145.12056719533 2552.01901693576 1.18968558502631 0.250580342559839 0.0758377533581953 0.94157495521624 28.8077 31.6417 37.5422 37.4034 GeneID:26262,Genbank:NM_012171.2,HGNC:HGNC:13594 tetraspanin 17 GO:0000151,GO:0004842,GO:0005887,GO:0007166,GO:0016567,GO:0019899,GO:0072594 ubiquitin ligase complex|ubiquitin-protein transferase activity|integral component of plasma membrane|cell surface receptor signaling pathway|protein ubiquitination|enzyme binding|establishment of protein localization to organelle TSPAN18 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0090156 0 0 0 GeneID:90139,Genbank:XM_011520459.3,HGNC:HGNC:20660 tetraspanin 18 GO:0005887,GO:0007166 integral component of plasma membrane|cell surface receptor signaling pathway TSPAN19 3.31322868058701 3.71865746181119 2.90779989936283 0.781948842888738 -0.35485386910013 0.957126709579746 1 0.109948 0 0.070879 0.0329923 GeneID:144448,Genbank:XM_017018863.2,HGNC:HGNC:31886 tetraspanin 19 GO:0005887,GO:0007166 integral component of plasma membrane|cell surface receptor signaling pathway TSPAN2 169.132948306352 188.991005363599 149.274891249106 0.789851828990044 -0.340346056319801 0.162748278702479 1 2.42999 2.32876 1.94487 1.69408 GeneID:10100,Genbank:XM_016999996.1,HGNC:HGNC:20659,MIM:613133 tetraspanin 2 GO:0005887,GO:0006954,GO:0007166,GO:0007420,GO:0014002,GO:0014005,GO:0016021,GO:0042552,GO:0043209,GO:0048709,GO:0061564 integral component of plasma membrane|inflammatory response|cell surface receptor signaling pathway|brain development|astrocyte development|microglia development|integral component of membrane|myelination|myelin sheath|oligodendrocyte differentiation|axon development TSPAN3 5699.84455316037 5850.63415181513 5549.05495450561 0.948453588195058 -0.0763509166318151 0.56017800511148 1 58.8056 61.3308 60.1803 55.3283 GeneID:10099,Genbank:NM_001168412.1,HGNC:HGNC:17752,MIM:613134 tetraspanin 3 GO:0005887,GO:0007166,GO:0070062 integral component of plasma membrane|cell surface receptor signaling pathway|extracellular exosome TSPAN31 464.879753968976 470.834811414601 458.924696523351 0.974704260172551 -0.0369635448495012 0.833124771550147 1 10.5205 10.8311 9.96219 10.8652 GeneID:6302,Genbank:NM_001330169.1,HGNC:HGNC:10539,MIM:181035 tetraspanin 31 GO:0005887,GO:0007166,GO:0008284,GO:0016020 integral component of plasma membrane|cell surface receptor signaling pathway|positive regulation of cell proliferation|membrane TSPAN32 2.22639791043881 3.96859749034384 0.484198330533773 0.122007417409273 -3.03495923616245 0.285827611520371 1 0.0156689 0.0674424 0 0.0135537 GeneID:10077,Genbank:XM_017017067.1,HGNC:HGNC:13410,MIM:603853 tetraspanin 32 GO:0005622,GO:0005887,GO:0007010,GO:0007166,GO:0007229,GO:0007267,GO:0008285,GO:0009986,GO:0030886,GO:0042832,GO:0050688,GO:0070442,GO:0070527 intracellular|integral component of plasma membrane|cytoskeleton organization|cell surface receptor signaling pathway|integrin-mediated signaling pathway|cell-cell signaling|negative regulation of cell proliferation|cell surface|negative regulation of myeloid dendritic cell activation|defense response to protozoan|regulation of defense response to virus|integrin alphaIIb-beta3 complex|platelet aggregation TSPAN33 187.672472878748 161.634267749103 213.710678008394 1.32218669335717 0.402925900419038 0.0876400623493144 0.970036792388817 2.46089 2.5431 3.36675 3.53785 GeneID:340348,Genbank:NM_178562.4,HGNC:HGNC:28743,MIM:610120 tetraspanin 33 GO:0005886,GO:0005887,GO:0007166,GO:0009986,GO:0019899,GO:0051604,GO:0072659,GO:0097197 plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|cell surface|enzyme binding|protein maturation|protein localization to plasma membrane|tetraspanin-enriched microdomain TSPAN4 1059.98288541987 1071.76785006537 1048.19792077438 0.978008363201459 -0.0320812928001566 0.807672751968246 1 20.0876 20.6192 19.6861 21.1927 GeneID:7106,Genbank:NM_003271.4,HGNC:HGNC:11859,MIM:602644 tetraspanin 4 GO:0003823,GO:0005178,GO:0005886,GO:0005887,GO:0005925,GO:0006461,GO:0007166,GO:0031982 antigen binding|integrin binding|plasma membrane|integral component of plasma membrane|focal adhesion|protein complex assembly|cell surface receptor signaling pathway|vesicle TSPAN5 1464.02649927302 1545.32933348105 1382.723665065 0.894776042301771 -0.160401466245298 0.272969559300758 1 21.3629 21.4039 21.2001 17.5592 GeneID:10098,Genbank:XM_005262680.1,HGNC:HGNC:17753,MIM:613136 tetraspanin 5 GO:0005886,GO:0005887,GO:0019899,GO:0045747,GO:0051604,GO:0072659 plasma membrane|integral component of plasma membrane|enzyme binding|positive regulation of Notch signaling pathway|protein maturation|protein localization to plasma membrane TSPAN6 751.147429224112 767.139611150045 735.155247298179 0.958306984299876 -0.0614402115954429 0.707156783273599 1 6.93067 6.8661 6.26606 6.65936 GeneID:7105,Genbank:NM_001278743.1,HGNC:HGNC:11858,MIM:300191 tetraspanin 6 GO:0004871,GO:0005887,GO:0007166,GO:0039532,GO:0043123,GO:0070062,GO:1901223 signal transducer activity|integral component of plasma membrane|cell surface receptor signaling pathway|negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|extracellular exosome|negative regulation of NIK/NF-kappaB signaling TSPAN7 68.4163458750224 63.17016757696 73.6625241730849 1.16609670353244 0.22168743512644 0.558437521866483 1 1.39071 1.88787 1.93406 1.90364 GeneID:7102,Genbank:NM_004615.3,HGNC:HGNC:11854,MIM:300096 tetraspanin 7 GO:0005887,GO:0007166,GO:0016032 integral component of plasma membrane|cell surface receptor signaling pathway|viral process hsa05202 Transcriptional misregulation in cancer TSPAN8 6.06021341987245 5.3329504917381 6.78747634800679 1.27274317631901 0.347941330762125 0.828902141167184 1 0.330606 0.0525683 0.423343 0.0982639 GeneID:7103,Genbank:XM_006719583.3,HGNC:HGNC:11855,MIM:600769 tetraspanin 8 TSPAN9 991.635151878309 848.21209788111 1135.05820587551 1.3381773364362 0.420269315862856 0.00639238686329707 0.31772812625209 8.34149 8.5573 12.3974 10.6264 GeneID:10867,Genbank:NM_006675.4,HGNC:HGNC:21640,MIM:613137 tetraspanin 9 GO:0005886,GO:0005887,GO:0005925,GO:0007166,GO:0097197 plasma membrane|integral component of plasma membrane|focal adhesion|cell surface receptor signaling pathway|tetraspanin-enriched microdomain TSPEAR 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:54084,Genbank:NM_144991.2,HGNC:HGNC:1268,MIM:612920 thrombospondin type laminin G domain and EAR repeats GO:0005576,GO:0007605,GO:0009986,GO:0032420,GO:0060170 extracellular region|sensory perception of sound|cell surface|stereocilium|ciliary membrane TSPO 1405.8641075435 1380.72826235744 1430.99995272957 1.0364095468621 0.0515942100432024 0.78077090708203 1 66.8018 67.3715 66.7528 76.5722 GeneID:706,Genbank:NM_000714.5,HGNC:HGNC:1158,MIM:109610 translocator protein hsa04080,hsa04979,hsa05166 Neuroactive ligand-receptor interaction|Cholesterol metabolism|Human T-cell leukemia virus 1 infection TSPOAP1 1.02523254288787 1.56626675524197 0.484198330533773 0.309141676482158 -1.69365993276169 0.789571303159055 1 0 0.00372864 0 0.00371018 GeneID:9256,Genbank:XM_017025327.1,HGNC:HGNC:16831,MIM:610764 TSPO associated protein 1 GO:0005737,GO:0005739,GO:0005829,GO:0006700,GO:0007269,GO:0014047,GO:0030156,GO:0098793 cytoplasm|mitochondrion|cytosol|C21-steroid hormone biosynthetic process|neurotransmitter secretion|glutamate secretion|benzodiazepine receptor binding|presynapse TSPYL1 2522.66413180624 2483.46259529207 2561.86566832042 1.03157006398123 0.0448418120392151 0.744268992785025 1 22.6522 22.9582 25.5689 21.9912 GeneID:7259,Genbank:NM_003309.3,HGNC:HGNC:12382,MIM:604714 TSPY like 1 GO:0005634,GO:0005730,GO:0006334,GO:0019899 nucleus|nucleolus|nucleosome assembly|enzyme binding TSPYL2 220.991734057966 237.478648192054 204.504819923878 0.861150345434386 -0.215662959846722 0.323010723585906 1 1.13138 1.31539 0.955483 1.10709 GeneID:64061,Genbank:NM_022117.3,HGNC:HGNC:24358,MIM:300564 TSPY like 2 GO:0000182,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006334,GO:0006351,GO:0006355,GO:0007049,GO:0008156,GO:0009966,GO:0016569,GO:0030308,GO:0036498,GO:0045786,GO:0045859 rDNA binding|nucleus|nucleoplasm|nucleolus|cytoplasm|nucleosome assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|negative regulation of DNA replication|regulation of signal transduction|covalent chromatin modification|negative regulation of cell growth|IRE1-mediated unfolded protein response|negative regulation of cell cycle|regulation of protein kinase activity TSPYL4 949.211562021058 909.765938426434 988.657185615682 1.08671598249293 0.119974935591267 0.419562794688486 1 10.4496 9.29597 11.359 10.4302 GeneID:23270,Genbank:NM_021648.4,HGNC:HGNC:21559 TSPY like 4 GO:0005634,GO:0006334 nucleus|nucleosome assembly TSR1 3188.69854587399 3419.15530874841 2958.24178299957 0.865196668729986 -0.208899984390963 0.123827287358787 1 23.8277 24.1152 22.1989 19.7814 GeneID:55720,Genbank:NM_018128.4,HGNC:HGNC:25542,MIM:611214 TSR1, ribosome maturation factor GO:0000462,GO:0000479,GO:0003723,GO:0003924,GO:0005525,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0030688,GO:0034511 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|GTPase activity|GTP binding|nucleoplasm|nucleolus|cytosol|rRNA processing|preribosome, small subunit precursor|U3 snoRNA binding TSR2 987.184559907309 925.699180318457 1048.66993949616 1.13284095070215 0.179945322993893 0.242704840057511 1 7.84128 8.03795 8.67333 9.36186 GeneID:90121,Genbank:NM_001346791.1,HGNC:HGNC:25455,MIM:300945 TSR2, ribosome maturation factor GO:0000462,GO:0005634 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nucleus TSR3 1222.04112465401 1182.14755136365 1261.93469794437 1.06749339072664 0.0942271375783898 0.553644355127694 1 49.9466 56.0454 57.2246 58.6545 GeneID:115939,Genbank:NM_001001410.2,HGNC:HGNC:14175,MIM:617058 TSR3, acp transferase ribosome maturation factor GO:0000154,GO:0005829,GO:0016740,GO:0030490 rRNA modification|cytosol|transferase activity|maturation of SSU-rRNA TSSC4 616.423938390996 614.500133425553 618.347743356438 1.00626136549302 0.00900507823129308 0.974025299588892 1 5.01134 5.07634 4.94725 5.36452 GeneID:10078,Genbank:XM_011519830.3,HGNC:HGNC:12386,MIM:603852 tumor suppressing subtransferable candidate 4 TSSK1B 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0.0174563 0.0313973 0 0 GeneID:83942,Genbank:NM_032028.3,HGNC:HGNC:14968,MIM:610709 testis specific serine kinase 1B GO:0000287,GO:0001669,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007275,GO:0007286,GO:0031514,GO:0035556 magnesium ion binding|acrosomal vesicle|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|multicellular organism development|spermatid development|motile cilium|intracellular signal transduction TSSK2 2.95062884258107 3.47852608838648 2.42273159677566 0.69648222701686 -0.521841556593199 0.840650475727963 1 0.0233085 0.122089 0.0215828 0 GeneID:23617,Genbank:NM_053006.4,HGNC:HGNC:11401,MIM:610710 testis specific serine kinase 2 GO:0000287,GO:0001669,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0005814,GO:0006468,GO:0007275,GO:0007286,GO:0035556,GO:0046777 magnesium ion binding|acrosomal vesicle|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|centriole|protein phosphorylation|multicellular organism development|spermatid development|intracellular signal transduction|protein autophosphorylation TSSK3 10.4254171781103 10.6757096385841 10.1751247176364 0.953109916071666 -0.0692854943645131 0.986808859983857 1 0.111024 0.117229 0.121878 0.129785 GeneID:81629,Genbank:XM_024450041.1,HGNC:HGNC:15473,MIM:607660 testis specific serine kinase 3 GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007275,GO:0007283,GO:0030154,GO:0035556 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|multicellular organism development|spermatogenesis|cell differentiation|intracellular signal transduction TSSK4 2.72710472925976 2.54640955915669 2.90779989936283 1.14192152982877 0.1914635154849 1 1 0.0262341 0.0237005 0.0493048 0.0229148 GeneID:283629,Genbank:XM_024449542.1,HGNC:HGNC:19825,MIM:610711 testis specific serine kinase 4 GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007275,GO:0007283,GO:0030154,GO:0032793,GO:0035556 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|multicellular organism development|spermatogenesis|cell differentiation|positive regulation of CREB transcription factor activity|intracellular signal transduction TSSK6 58.1468395294356 50.870356253341 65.4233228055301 1.28607950924726 0.362979837106664 0.339705923451413 1 1.98763 1.55251 1.98943 1.85207 GeneID:83983,Genbank:NM_032037.3,HGNC:HGNC:30410,MIM:610712 testis specific serine kinase 6 GO:0000287,GO:0004674,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0007275,GO:0035092,GO:0035556 magnesium ion binding|protein serine/threonine kinase activity|ATP binding|nucleus|cytoplasm|protein phosphorylation|multicellular organism development|sperm chromatin condensation|intracellular signal transduction TST 117.110564581052 118.393331518124 115.827797643979 0.978330419110199 -0.0316062948388363 0.922411777130491 1 5.08618 4.93468 5.13045 5.04567 GeneID:7263,Genbank:NM_001270483.1,HGNC:HGNC:12388,MIM:180370 thiosulfate sulfurtransferase GO:0004792,GO:0005615,GO:0005739,GO:0005743,GO:0005759,GO:0008097,GO:0009440,GO:0030855,GO:0035928,GO:0051029,GO:0070062 thiosulfate sulfurtransferase activity|extracellular space|mitochondrion|mitochondrial inner membrane|mitochondrial matrix|5S rRNA binding|cyanate catabolic process|epithelial cell differentiation|rRNA import into mitochondrion|rRNA transport|extracellular exosome hsa00270,hsa00920,hsa04122 Cysteine and methionine metabolism|Sulfur metabolism|Sulfur relay system TSTA3 848.085376628667 867.497370345971 828.673382911363 0.955245988331786 -0.0660558010598667 0.665005267848943 1 15.7176 16.0824 14.3192 15.8417 GeneID:7264,Genbank:XM_011517269.1,HGNC:HGNC:12390,MIM:137020 tissue specific transplantation antigen P35B GO:0005829,GO:0007159,GO:0009055,GO:0016853,GO:0019673,GO:0019835,GO:0042351,GO:0042356,GO:0042802,GO:0050577,GO:0050662,GO:0070062 cytosol|leukocyte cell-cell adhesion|electron transfer activity|isomerase activity|GDP-mannose metabolic process|cytolysis|'de novo' GDP-L-fucose biosynthetic process|GDP-4-dehydro-D-rhamnose reductase activity|identical protein binding|GDP-L-fucose synthase activity|coenzyme binding|extracellular exosome hsa00051,hsa00520 Fructose and mannose metabolism|Amino sugar and nucleotide sugar metabolism TSTD1 60.316546851704 62.9682538231123 57.6648398802956 0.915776385387551 -0.126932731364791 0.745229798780573 1 1.11185 1.81389 1.37884 2.34716 GeneID:100131187,Genbank:NM_001113206.1,HGNC:HGNC:35410,MIM:616041 thiosulfate sulfurtransferase like domain containing 1 GO:0005737,GO:0005739,GO:0005829,GO:0036464,GO:0048471,GO:0050337,GO:0070221 cytoplasm|mitochondrion|cytosol|cytoplasmic ribonucleoprotein granule|perinuclear region of cytoplasm|thiosulfate-thiol sulfurtransferase activity|sulfide oxidation, using sulfide:quinone oxidoreductase TSTD2 391.866169902295 388.76358157026 394.96875823433 1.01596131159973 0.0228454644861242 0.910116991799265 1 3.59133 3.63308 3.73738 3.74041 GeneID:158427,Genbank:NM_139246.4,HGNC:HGNC:30087 thiosulfate sulfurtransferase like domain containing 2 TSTD3 123.730075071994 130.673525531528 116.78662461246 0.893728275390278 -0.162091826492342 0.572376783171914 1 1.05826 0.911403 0.922895 1.04197 GeneID:100130890,Genbank:XM_017010141.2,HGNC:HGNC:40910 thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 TTBK1 6.6262262019027 1.61429302992691 11.6381593738785 7.20944658629011 2.84988851912521 0.190266889896057 1 0.00669004 0 0.0558284 0.0116239 GeneID:84630,Genbank:NM_032538.2,HGNC:HGNC:19140 tau tubulin kinase 1 GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006468,GO:0007611,GO:0008360,GO:0010628,GO:0010629,GO:0018105,GO:0018107,GO:0018108,GO:0021762,GO:0032091,GO:0032273,GO:0045298,GO:0048471,GO:0061890,GO:1903980,GO:1904031,GO:2001056 protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|protein phosphorylation|learning or memory|regulation of cell shape|positive regulation of gene expression|negative regulation of gene expression|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|peptidyl-tyrosine phosphorylation|substantia nigra development|negative regulation of protein binding|positive regulation of protein polymerization|tubulin complex|perinuclear region of cytoplasm|positive regulation of astrocyte activation|positive regulation of microglial cell activation|positive regulation of cyclin-dependent protein kinase activity|positive regulation of cysteine-type endopeptidase activity TTBK2 424.547014093449 404.098856854138 444.99517133276 1.10120373711768 0.13908141107953 0.727845380237357 1 1.27487 1.10187 1.69759 0.937208 GeneID:146057,Genbank:XM_005254171.5,HGNC:HGNC:19141,MIM:611695 tau tubulin kinase 2 GO:0000226,GO:0004672,GO:0004674,GO:0005524,GO:0005615,GO:0005634,GO:0005814,GO:0005829,GO:0007026,GO:0007224,GO:0008360,GO:0018105,GO:0019894,GO:0021549,GO:0021681,GO:0021935,GO:0030334,GO:0035869,GO:0036064,GO:0050321,GO:0051010,GO:0060271,GO:0097711,GO:1902817,GO:1904527 microtubule cytoskeleton organization|protein kinase activity|protein serine/threonine kinase activity|ATP binding|extracellular space|nucleus|centriole|cytosol|negative regulation of microtubule depolymerization|smoothened signaling pathway|regulation of cell shape|peptidyl-serine phosphorylation|kinesin binding|cerebellum development|cerebellar granular layer development|cerebellar granule cell precursor tangential migration|regulation of cell migration|ciliary transition zone|ciliary basal body|tau-protein kinase activity|microtubule plus-end binding|cilium assembly|ciliary basal body-plasma membrane docking|negative regulation of protein localization to microtubule|negative regulation of microtubule binding TTC1 2140.19702699191 2167.53633916897 2112.85771481484 0.974773837298115 -0.036860564904065 0.791085642325782 1 43.0442 46.7499 41.9008 44.3726 GeneID:7265,Genbank:NM_003314.2,HGNC:HGNC:12391,MIM:601963 tetratricopeptide repeat domain 1 GO:0005778,GO:0005829,GO:0006457,GO:0051082 peroxisomal membrane|cytosol|protein folding|unfolded protein binding TTC12 261.857449573635 255.23587152125 268.479027626021 1.05188595171141 0.0729782922539639 0.727726918346705 1 1.30363 1.40381 1.30408 1.40922 GeneID:54970,Genbank:NM_001352038.1,HGNC:HGNC:23700,MIM:610732 tetratricopeptide repeat domain 12 GO:0005813 centrosome TTC13 625.811602356063 720.026129978092 531.597074734034 0.738302476259033 -0.437716097577453 0.00865888429630992 0.362097302226572 3.3969 3.39798 2.40615 2.62301 GeneID:79573,Genbank:NM_001122835.2,HGNC:HGNC:26204 tetratricopeptide repeat domain 13 TTC14 340.958504706044 351.354458887229 330.562550524858 0.940823553433131 -0.0880039165202475 0.806378146321891 1 2.58764 2.14251 2.55628 1.84631 GeneID:151613,Genbank:NM_001288582.1,HGNC:HGNC:24697 tetratricopeptide repeat domain 14 GO:0003676 nucleic acid binding TTC17 2570.49885097444 2563.11086009024 2577.88684185865 1.00576486253423 0.00829305732322431 0.940788216841138 1 10.5488 10.5631 11.7841 9.88509 GeneID:55761,Genbank:NM_018259.5,HGNC:HGNC:25596 tetratricopeptide repeat domain 17 GO:0005737,GO:0005829,GO:0005886,GO:0015629,GO:0030041,GO:0044782 cytoplasm|cytosol|plasma membrane|actin cytoskeleton|actin filament polymerization|cilium organization TTC19 2283.54363596356 2335.8581017561 2231.22917017102 0.955207496762575 -0.0661139355252765 0.634859510982177 1 16.9626 17.5247 17.1201 16.1819 GeneID:54902,Genbank:NM_001271420.1,HGNC:HGNC:26006,MIM:613814 tetratricopeptide repeat domain 19 GO:0000910,GO:0005739,GO:0005743,GO:0005813,GO:0030496,GO:0034551,GO:0055114,GO:0070469 cytokinesis|mitochondrion|mitochondrial inner membrane|centrosome|midbody|mitochondrial respiratory chain complex III assembly|oxidation-reduction process|respiratory chain TTC21A 31.7021895437039 30.4510535054025 32.9533255820053 1.0821735798454 0.113931924947786 0.837110701596626 1 0.152772 0.146043 0.167258 0.190985 GeneID:199223,Genbank:NM_145755.2,HGNC:HGNC:30761,MIM:611430 tetratricopeptide repeat domain 21A GO:0005929,GO:0030991,GO:0035721,GO:0061512 cilium|intraciliary transport particle A|intraciliary retrograde transport|protein localization to cilium TTC21B 126.737344044172 138.120649110258 115.354038978086 0.83516867116663 -0.259860500317043 0.342880397091003 1 0.272735 0.276432 0.261777 0.185602 GeneID:79809,Genbank:NM_024753.4,HGNC:HGNC:25660,MIM:612014 tetratricopeptide repeat domain 21B GO:0000790,GO:0005737,GO:0005856,GO:0005929,GO:0006357,GO:0007224,GO:0008589,GO:0021591,GO:0021798,GO:0030991,GO:0035721,GO:0035735,GO:0061512,GO:0097542 nuclear chromatin|cytoplasm|cytoskeleton|cilium|regulation of transcription from RNA polymerase II promoter|smoothened signaling pathway|regulation of smoothened signaling pathway|ventricular system development|forebrain dorsal/ventral pattern formation|intraciliary transport particle A|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|protein localization to cilium|ciliary tip TTC23 656.025607854627 635.053706342438 676.997509366816 1.06604764700288 0.0922719207974459 0.582147677934764 1 3.49327 3.54466 3.73952 3.75845 GeneID:64927,Genbank:NM_001288616.2,HGNC:HGNC:25730 tetratricopeptide repeat domain 23 TTC23L 6.0933627839019 7.34126237425249 4.84546319355132 0.660031333377415 -0.599393580362928 0.687855499406484 1 0.027334 0.00654667 0.0197445 0.0306076 GeneID:153657,Genbank:XM_011513984.3,HGNC:HGNC:26355,MIM:616344 tetratricopeptide repeat domain 23 like GO:0005737,GO:0005815,GO:0005819,GO:0030496,GO:0034976 cytoplasm|microtubule organizing center|spindle|midbody|response to endoplasmic reticulum stress TTC24 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0137333 0 0 0 GeneID:164118,Genbank:NM_001105669.3,HGNC:HGNC:32348 tetratricopeptide repeat domain 24 TTC25 28.1177370946622 26.194298366949 30.0411758223755 1.14685934326381 0.197688462653538 0.735660788269323 1 0.189035 0.193928 0.198999 0.290527 GeneID:83538,Genbank:NM_031421.4,HGNC:HGNC:25280,MIM:617095 tetratricopeptide repeat domain 25 GO:0005737,GO:0005856,GO:0042995 cytoplasm|cytoskeleton|cell projection TTC26 252.440027834983 278.067313659398 226.812742010568 0.815675668692179 -0.293932477228782 0.160444319606521 1 1.90178 2.20806 1.57513 1.43341 GeneID:79989,Genbank:NM_001318333.1,HGNC:HGNC:21882,MIM:617453 tetratricopeptide repeat domain 26 GO:0005813,GO:0005929,GO:0007224,GO:0007286,GO:0030992,GO:0035735,GO:0036064,GO:0042073,GO:0060271,GO:0097542 centrosome|cilium|smoothened signaling pathway|spermatid development|intraciliary transport particle B|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|cilium assembly|ciliary tip TTC27 289.222419487177 287.65701928959 290.787819684763 1.01088379627553 0.0156171652207873 0.950336590164246 1 3.67051 3.85539 4.11407 3.51619 GeneID:55622,Genbank:NM_017735.4,HGNC:HGNC:25986 tetratricopeptide repeat domain 27 TTC28 1197.29181811667 1125.75010551812 1268.83353071521 1.12710052123978 0.172616189003501 0.247397653301658 1 1.85025 1.85752 2.27924 1.89534 GeneID:23331,Genbank:XM_005261405.2,HGNC:HGNC:29179,MIM:615098 tetratricopeptide repeat domain 28 GO:0000922,GO:0005737,GO:0005815,GO:0007049,GO:0007346,GO:0019900,GO:0030496,GO:0051301 spindle pole|cytoplasm|microtubule organizing center|cell cycle|regulation of mitotic cell cycle|kinase binding|midbody|cell division TTC29 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:83894,Genbank:NM_001317806.1,HGNC:HGNC:29936 tetratricopeptide repeat domain 29 TTC3 490.983497289137 479.798141472179 502.168853106095 1.04662525695759 0.0657449793221027 0.846636785522646 1 1.48568 1.02408 1.62585 1.04863 GeneID:7267,Genbank:NM_001320703.1,HGNC:HGNC:12393,MIM:602259 tetratricopeptide repeat domain 3 GO:0004842,GO:0005634,GO:0005730,GO:0005829,GO:0006511,GO:0046872,GO:0070936 ubiquitin-protein transferase activity|nucleus|nucleolus|cytosol|ubiquitin-dependent protein catabolic process|metal ion binding|protein K48-linked ubiquitination TTC30A 67.203592564469 73.3459971584789 61.0611879704592 0.832508798517309 -0.264462575243749 0.463459258372659 1 0.702772 0.736426 0.603838 0.635232 GeneID:92104,Genbank:NM_152275.3,HGNC:HGNC:25853 tetratricopeptide repeat domain 30A GO:0005929,GO:0030992,GO:0042073,GO:0060271 cilium|intraciliary transport particle B|intraciliary transport|cilium assembly TTC30B 55.0986847596976 61.2480995887076 48.9492699306877 0.799196550740206 -0.323377738284481 0.419379694027909 1 0.976168 0.903192 0.789639 0.731537 GeneID:150737,Genbank:NM_152517.2,HGNC:HGNC:26425 tetratricopeptide repeat domain 30B GO:0005929,GO:0030992,GO:0035735,GO:0042073,GO:0060271,GO:0097542 cilium|intraciliary transport particle B|intraciliary transport involved in cilium assembly|intraciliary transport|cilium assembly|ciliary tip TTC31 482.329494107324 506.714867961112 457.944120253536 0.903751101869546 -0.146002593862876 0.408137104667925 1 4.8132 4.62777 3.93075 4.71909 GeneID:64427,Genbank:XM_011533040.2,HGNC:HGNC:25759 tetratricopeptide repeat domain 31 TTC32 39.7847458056728 43.2311275758709 36.3383640354747 0.840560172105171 -0.250576995365862 0.603894782866978 1 1.61679 1.5481 0.988069 1.88774 GeneID:130502,Genbank:NM_001008237.2,HGNC:HGNC:32954 tetratricopeptide repeat domain 32 TTC33 211.072548546182 197.744647013931 224.400450078433 1.13479911323528 0.182436928361888 0.405014487780914 1 1.47255 1.29645 1.71376 1.32587 GeneID:23548,Genbank:NM_012382.2,HGNC:HGNC:29959 tetratricopeptide repeat domain 33 TTC34 9.88155479651948 8.12930007942745 11.6338095136115 1.43109608452674 0.51712053860308 0.619889230822708 1 0.0498272 0.0578246 0.092398 0.0651175 GeneID:100287898,Genbank:XM_016999990.1,HGNC:HGNC:34297 tetratricopeptide repeat domain 34 TTC36 2.72840968733986 2.54640955915669 2.91040981552302 1.14294646949365 0.1927578357444 1 1 0.101443 0.132808 0.186322 0.0872868 GeneID:143941,Genbank:NM_001346096.1,HGNC:HGNC:33708 tetratricopeptide repeat domain 36 TTC37 518.102517422862 534.050971264537 502.154063581187 0.940273664126435 -0.0888473844611916 0.822982022808959 1 3.69925 2.67387 3.66587 2.45887 GeneID:9652,Genbank:NM_014639.3,HGNC:HGNC:23639,MIM:614589 tetratricopeptide repeat domain 37 GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0035327,GO:0043928,GO:0055087 nucleus|nucleoplasm|cytoplasm|cytosol|transcriptionally active chromatin|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|Ski complex hsa03018 RNA degradation TTC38 634.512662270376 581.3771918463 687.648132694452 1.18279172684891 0.242196057536212 0.142831852526309 1 4.86465 4.51154 5.05594 5.78003 GeneID:55020,Genbank:NM_017931.2,HGNC:HGNC:26082 tetratricopeptide repeat domain 38 GO:0070062 extracellular exosome TTC39A 27.6222147011132 19.3911336693388 35.8532957328875 1.84895304958774 0.88670859089304 0.141431593241456 1 0.0994276 0.114178 0.136169 0.333997 GeneID:22996,Genbank:NM_001144832.2,HGNC:HGNC:18657 tetratricopeptide repeat domain 39A TTC39B 244.883402548667 217.375912056694 272.39089304064 1.25308683222269 0.325486389182204 0.122543191970169 1 1.27142 1.13867 1.84601 1.34773 GeneID:158219,Genbank:NM_001168341.1,HGNC:HGNC:23704,MIM:613574 tetratricopeptide repeat domain 39B TTC39C 122.034025498472 142.771423101299 101.296627895646 0.709502123711228 -0.495121092260349 0.0723334989022855 0.929024313086611 0.595884 0.635017 0.459109 0.350305 GeneID:125488,Genbank:NM_153211.3,HGNC:HGNC:26595 tetratricopeptide repeat domain 39C TTC4 966.879896686194 999.429387674415 934.330405697972 0.93486385053383 -0.0971718223598138 0.526471692768714 1 15.0655 15.7658 14.2383 14.9161 GeneID:7268,Genbank:NM_004623.4,HGNC:HGNC:12394,MIM:606753 tetratricopeptide repeat domain 4 TTC5 300.157193994912 308.586010749702 291.728377240122 0.945371361881817 -0.0810469330645787 0.669895188915285 1 5.40648 6.51459 5.56692 5.93436 GeneID:91875,Genbank:NM_138376.2,HGNC:HGNC:19274 tetratricopeptide repeat domain 5 GO:0003677,GO:0003682,GO:0005654,GO:0005737,GO:0006281,GO:0045944,GO:1901796 DNA binding|chromatin binding|nucleoplasm|cytoplasm|DNA repair|positive regulation of transcription from RNA polymerase II promoter|regulation of signal transduction by p53 class mediator TTC6 13.9472690403831 11.8959838159236 15.9985542648426 1.34487021102261 0.42746694977149 0.595233287794812 1 0.0351066 0.0293663 0.080128 0.0117624 GeneID:319089,Genbank:XM_024449560.1,HGNC:HGNC:19739 tetratricopeptide repeat domain 6 TTC7A 617.455244250807 548.707121050282 686.203367451331 1.25058221613357 0.322599906706532 0.0560810989041256 0.858942249947038 1.72101 1.99972 2.37288 2.43405 GeneID:57217,Genbank:NM_001288953.1,HGNC:HGNC:19750,MIM:609332 tetratricopeptide repeat domain 7A GO:0005737,GO:0005886,GO:0006879,GO:0030097,GO:0072659 cytoplasm|plasma membrane|cellular iron ion homeostasis|hemopoiesis|protein localization to plasma membrane TTC7B 452.680898002155 444.476816913381 460.884979090928 1.03691567603344 0.0522985762004965 0.771650542819672 1 4.44956 4.12121 4.63618 4.3136 GeneID:145567,Genbank:XM_017021046.1,HGNC:HGNC:19858 tetratricopeptide repeat domain 7B GO:0005829,GO:0005886,GO:0046854,GO:0072659 cytosol|plasma membrane|phosphatidylinositol phosphorylation|protein localization to plasma membrane TTC8 287.876356948297 304.338047265501 271.414666631092 0.891819702037823 -0.165176022934257 0.426827711623036 1 2.92266 2.54302 2.78622 2.13265 GeneID:123016,Genbank:NM_144596.3,HGNC:HGNC:20087,MIM:608132 tetratricopeptide repeat domain 8 GO:0001103,GO:0005813,GO:0005829,GO:0005929,GO:0015031,GO:0034464,GO:0036064,GO:0048560,GO:0050893,GO:0060170,GO:0060271,GO:1905515 RNA polymerase II repressing transcription factor binding|centrosome|cytosol|cilium|protein transport|BBSome|ciliary basal body|establishment of anatomical structure orientation|sensory processing|ciliary membrane|cilium assembly|non-motile cilium assembly TTC9 60.6529457160391 58.3174798320713 62.9884116000069 1.08009488375331 0.111158055266082 0.800567886396977 1 0.393223 0.465085 0.372948 0.56091 GeneID:23508,Genbank:NM_015351.1,HGNC:HGNC:20267,MIM:610488 tetratricopeptide repeat domain 9 GO:0060348 bone development TTC9B 1.02229600717608 1.07619535328461 0.968396661067546 0.899833527539349 -0.152269972565186 1 1 0.127118 0 0 0.0542555 GeneID:148014,Genbank:NM_152479.5,HGNC:HGNC:26395 tetratricopeptide repeat domain 9B TTC9C 363.253700803639 351.874973255365 374.632428351912 1.06467483289876 0.0904128777800513 0.662987633061538 1 5.62049 7.60936 7.49265 6.79165 GeneID:283237,Genbank:NM_001318812.1,HGNC:HGNC:28432 tetratricopeptide repeat domain 9C TTF1 232.055772595025 253.775465970486 210.336079219565 0.828827477136924 -0.270856263107969 0.211246608140792 1 1.96586 2.14488 1.86907 1.65457 GeneID:7270,Genbank:NM_001205296.1,HGNC:HGNC:12397,MIM:600777 transcription termination factor 1 GO:0000981,GO:0001135,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0005886,GO:0006353,GO:0006357,GO:0006363,GO:0008156,GO:0030154,GO:0043565,GO:0044212,GO:0044267 RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcription factor activity, RNA polymerase II transcription factor recruiting|nucleus|nucleoplasm|nucleolus|cytosol|plasma membrane|DNA-templated transcription, termination|regulation of transcription from RNA polymerase II promoter|termination of RNA polymerase I transcription|negative regulation of DNA replication|cell differentiation|sequence-specific DNA binding|transcription regulatory region DNA binding|cellular protein metabolic process hsa04918 Thyroid hormone synthesis TTF2 2139.36155846479 2117.69313499337 2161.02998193621 1.02046417690398 0.0292255378727293 0.829433850074002 1 6.92248 6.94259 7.61057 6.827 GeneID:8458,Genbank:XM_011542303.3,HGNC:HGNC:12398,MIM:604718 transcription termination factor 2 GO:0003677,GO:0004386,GO:0005524,GO:0005681,GO:0005829,GO:0006353,GO:0006355,GO:0006369,GO:0006397,GO:0008023,GO:0008094,GO:0008270,GO:0008380 DNA binding|helicase activity|ATP binding|spliceosomal complex|cytosol|DNA-templated transcription, termination|regulation of transcription, DNA-templated|termination of RNA polymerase II transcription|mRNA processing|transcription elongation factor complex|DNA-dependent ATPase activity|zinc ion binding|RNA splicing hsa04918 Thyroid hormone synthesis TTI1 930.979357891694 920.28877758671 941.669938196678 1.02323309936044 0.0331348381269595 0.829176944728329 1 7.39786 6.92593 7.83057 6.79527 GeneID:9675,Genbank:NM_001303457.1,HGNC:HGNC:29029,MIM:614425 TELO2 interacting protein 1 GO:0005737,GO:0031931,GO:0031932,GO:0032006 cytoplasm|TORC1 complex|TORC2 complex|regulation of TOR signaling hsa04150 mTOR signaling pathway TTI2 505.943709118183 493.358478594424 518.528939641942 1.05101860440147 0.0717882071118682 0.691804495198622 1 5.80918 6.33821 6.61462 6.74778 GeneID:80185,Genbank:NM_001330505.1,HGNC:HGNC:26262,MIM:614426 TELO2 interacting protein 2 GO:0005654,GO:0005813,GO:0005829 nucleoplasm|centrosome|cytosol TTK 406.712329822945 452.807013745802 360.617645900088 0.796404726412945 -0.328426311859732 0.243543088802473 1 4.10161 3.40959 3.52785 2.34304 GeneID:7272,Genbank:XM_011536099.3,HGNC:HGNC:12401,MIM:604092 TTK protein kinase GO:0000776,GO:0004674,GO:0004712,GO:0004713,GO:0005524,GO:0005737,GO:0005819,GO:0007051,GO:0007052,GO:0007094,GO:0008284,GO:0010862,GO:0016020,GO:0016321,GO:0018105,GO:0018107,GO:0033316,GO:0034501,GO:0042803,GO:0046777,GO:0051304,GO:1903096 kinetochore|protein serine/threonine kinase activity|protein serine/threonine/tyrosine kinase activity|protein tyrosine kinase activity|ATP binding|cytoplasm|spindle|spindle organization|mitotic spindle organization|mitotic spindle assembly checkpoint|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|membrane|female meiosis chromosome segregation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|meiotic spindle assembly checkpoint|protein localization to kinetochore|protein homodimerization activity|protein autophosphorylation|chromosome separation|protein localization to meiotic spindle midzone hsa04110 Cell cycle TTL 1894.59820529934 2028.96383627633 1760.23257432236 0.867552463405574 -0.204977090618427 0.146368681775311 1 15.2183 15.5763 14.6012 12.6623 GeneID:150465,Genbank:XM_005263599.3,HGNC:HGNC:21586,MIM:608291 tubulin tyrosine ligase GO:0000226,GO:0004835,GO:0005524,GO:0005623,GO:0018166,GO:0030516,GO:0045931,GO:0090235 microtubule cytoskeleton organization|tubulin-tyrosine ligase activity|ATP binding|cell|C-terminal protein-tyrosinylation|regulation of axon extension|positive regulation of mitotic cell cycle|regulation of metaphase plate congression TTLL1 124.894703336046 119.431309251832 130.35809742026 1.09149014807656 0.126299108445758 0.672665254763608 1 1.23029 1.34559 1.2859 1.36394 GeneID:25809,Genbank:NM_012263.4,HGNC:HGNC:1312,MIM:608955 tubulin tyrosine ligase like 1 GO:0003351,GO:0005524,GO:0005737,GO:0005874,GO:0007288,GO:0018095,GO:0070740,GO:1905419 epithelial cilium movement|ATP binding|cytoplasm|microtubule|sperm axoneme assembly|protein polyglutamylation|tubulin-glutamic acid ligase activity|sperm flagellum movement involved in flagellated sperm motility TTLL10 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:254173,Genbank:XM_011541177.2,HGNC:HGNC:26693 tubulin tyrosine ligase like 10 GO:0005524,GO:0005829,GO:0018094,GO:0070735 ATP binding|cytosol|protein polyglycylation|protein-glycine ligase activity TTLL11 94.4781927047069 90.0946687192911 98.8617166901226 1.09730928694734 0.133970220231035 0.680676948416473 1 0.223435 0.244536 0.231886 0.264551 GeneID:158135,Genbank:XM_005251728.2,HGNC:HGNC:18113 tubulin tyrosine ligase like 11 GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0018095,GO:0051013,GO:0070740 ATP binding|cytosol|microtubule|cilium|protein polyglutamylation|microtubule severing|tubulin-glutamic acid ligase activity TTLL12 1769.4379471822 1863.53549282712 1675.34040153728 0.899011802021366 -0.153588039652718 0.27154655893457 1 20.5671 20.7258 19.5731 19.0756 GeneID:23170,Genbank:NM_015140.3,HGNC:HGNC:28974 tubulin tyrosine ligase like 12 GO:0003824,GO:0005524,GO:0006464 catalytic activity|ATP binding|cellular protein modification process TTLL3 16.4156577496137 16.3546527082248 16.4766627910026 1.00746026742081 0.0107229423509749 1 1 0.122163 0.170246 0.189981 0.221131 GeneID:26140,Genbank:NM_001025930.3,HGNC:HGNC:24483 tubulin tyrosine ligase like 3 GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0005930,GO:0015630,GO:0018094,GO:0035082,GO:0060271,GO:0070735,GO:0070736 ATP binding|cytosol|microtubule|cilium|axoneme|microtubule cytoskeleton|protein polyglycylation|axoneme assembly|cilium assembly|protein-glycine ligase activity|protein-glycine ligase activity, initiating TTLL4 533.706334452244 539.14582438456 528.266844519928 0.979821823015972 -0.0294086705800236 0.856660315025753 1 2.03347 2.40491 2.33672 2.15479 GeneID:9654,Genbank:XM_017005387.1,HGNC:HGNC:28976 tubulin tyrosine ligase like 4 GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0015631,GO:0018095,GO:0018200,GO:0070739,GO:0070740 ATP binding|cytosol|microtubule|cilium|tubulin binding|protein polyglutamylation|peptidyl-glutamic acid modification|protein-glutamic acid ligase activity|tubulin-glutamic acid ligase activity TTLL5 537.799145182938 555.106458240197 520.491832125679 0.937643265358049 -0.0928889537989231 0.581358881862774 1 3.07375 3.39087 3.14729 2.94079 GeneID:23093,Genbank:NM_015072.4,HGNC:HGNC:19963,MIM:612268 tubulin tyrosine ligase like 5 GO:0005524,GO:0005634,GO:0005813,GO:0005829,GO:0005874,GO:0005886,GO:0005929,GO:0006351,GO:0007288,GO:0009566,GO:0018095,GO:0060041,GO:0070740 ATP binding|nucleus|centrosome|cytosol|microtubule|plasma membrane|cilium|transcription, DNA-templated|sperm axoneme assembly|fertilization|protein polyglutamylation|retina development in camera-type eye|tubulin-glutamic acid ligase activity TTLL6 3.77504545141001 4.16070258908361 3.38938831373641 0.814619223837126 -0.295802234625039 0.954312641941452 1 0.0282753 0.0195586 0 0.031219 GeneID:284076,Genbank:NM_001130918.1,HGNC:HGNC:26664,MIM:610849 tubulin tyrosine ligase like 6 GO:0001578,GO:0003353,GO:0005524,GO:0005829,GO:0005874,GO:0015631,GO:0018095,GO:0036064,GO:0051013,GO:0070739,GO:0070740 microtubule bundle formation|positive regulation of cilium movement|ATP binding|cytosol|microtubule|tubulin binding|protein polyglutamylation|ciliary basal body|microtubule severing|protein-glutamic acid ligase activity|tubulin-glutamic acid ligase activity TTLL7 360.765199744934 360.935372863168 360.595026626699 0.999057043830954 -0.00136103999028343 1 1 1.40425 1.32402 1.44841 1.17206 GeneID:79739,Genbank:XM_024449807.1,HGNC:HGNC:26242 tubulin tyrosine ligase like 7 GO:0005524,GO:0005829,GO:0005874,GO:0005929,GO:0007399,GO:0018095,GO:0030154,GO:0030425,GO:0043014,GO:0043204,GO:0048487,GO:0070740 ATP binding|cytosol|microtubule|cilium|nervous system development|protein polyglutamylation|cell differentiation|dendrite|alpha-tubulin binding|perikaryon|beta-tubulin binding|tubulin-glutamic acid ligase activity TTLL9 1.72795188737276 1.51824048055703 1.93766329418849 1.27625584945382 0.351917573411544 1 1 0.00621172 0.00571065 0 0.00548889 GeneID:164395,Genbank:NM_001008409.3,HGNC:HGNC:16118 tubulin tyrosine ligase like 9 GO:0005524,GO:0005737,GO:0005874,GO:0005929,GO:0006464,GO:0016874 ATP binding|cytoplasm|microtubule|cilium|cellular protein modification process|ligase activity TTN 0.753682154881624 0.538097676642304 0.969266633120943 1.801283809975 0.849025509942274 1 1 0 0 0.000251197 0 GeneID:7273,Genbank:NM_003319.4,HGNC:HGNC:12403,MIM:188840 titin GO:0000794,GO:0001701,GO:0001756,GO:0002020,GO:0003007,GO:0003300,GO:0004674,GO:0004713,GO:0005200,GO:0005509,GO:0005516,GO:0005524,GO:0005859,GO:0005865,GO:0006936,GO:0006941,GO:0007015,GO:0007507,GO:0007512,GO:0008307,GO:0010628,GO:0010737,GO:0019899,GO:0019901,GO:0021591,GO:0030017,GO:0030018,GO:0030240,GO:0030241,GO:0030506,GO:0031430,GO:0031433,GO:0031672,GO:0031674,GO:0035995,GO:0042802,GO:0042805,GO:0043056,GO:0043621,GO:0045214,GO:0045859,GO:0048739,GO:0048769,GO:0050714,GO:0050790,GO:0051015,GO:0051371,GO:0051592,GO:0055002,GO:0055003,GO:0055008,GO:0060048,GO:0060419,GO:0071688,GO:0097493,GO:1901897 condensed nuclear chromosome|in utero embryonic development|somitogenesis|protease binding|heart morphogenesis|cardiac muscle hypertrophy|protein serine/threonine kinase activity|protein tyrosine kinase activity|structural constituent of cytoskeleton|calcium ion binding|calmodulin binding|ATP binding|muscle myosin complex|striated muscle thin filament|muscle contraction|striated muscle contraction|actin filament organization|heart development|adult heart development|structural constituent of muscle|positive regulation of gene expression|protein kinase A signaling|enzyme binding|protein kinase binding|ventricular system development|sarcomere|Z disc|skeletal muscle thin filament assembly|skeletal muscle myosin thick filament assembly|ankyrin binding|M band|telethonin binding|A band|I band|detection of muscle stretch|identical protein binding|actinin binding|forward locomotion|protein self-association|sarcomere organization|regulation of protein kinase activity|cardiac muscle fiber development|sarcomerogenesis|positive regulation of protein secretion|regulation of catalytic activity|actin filament binding|muscle alpha-actinin binding|response to calcium ion|striated muscle cell development|cardiac myofibril assembly|cardiac muscle tissue morphogenesis|cardiac muscle contraction|heart growth|striated muscle myosin thick filament assembly|structural molecule activity conferring elasticity|regulation of relaxation of cardiac muscle hsa05410,hsa05414 Hypertrophic cardiomyopathy (HCM)|Dilated cardiomyopathy (DCM) TTPA 54.4826650049455 60.5080881582176 48.4572418516734 0.800839083280347 -0.320415711274353 0.437842916330611 1 1.02045 0.635701 0.706139 0.750679 GeneID:7274,Genbank:NM_000370.3,HGNC:HGNC:12404,MIM:600415 alpha tocopherol transfer protein GO:0001892,GO:0005546,GO:0005770,GO:0005829,GO:0006629,GO:0006810,GO:0007584,GO:0008431,GO:0009268,GO:0009636,GO:0042360,GO:0043325,GO:0051180,GO:0051452,GO:0060548,GO:0090212,GO:0120009,GO:0120013 embryonic placenta development|phosphatidylinositol-4,5-bisphosphate binding|late endosome|cytosol|lipid metabolic process|transport|response to nutrient|vitamin E binding|response to pH|response to toxic substance|vitamin E metabolic process|phosphatidylinositol-3,4-bisphosphate binding|vitamin transport|intracellular pH reduction|negative regulation of cell death|negative regulation of establishment of blood-brain barrier|intermembrane lipid transfer|intermembrane lipid transfer activity TTPAL 691.308494000798 641.568713391939 741.048274609657 1.15505675252114 0.207963738714329 0.205313766783706 1 3.14846 3.32599 4.02855 3.39907 GeneID:79183,Genbank:XM_024452000.1,HGNC:HGNC:16114 alpha tocopherol transfer protein like GO:0016020 membrane TTYH1 41.8537361100245 30.4030272307176 53.3044449893315 1.75326110077208 0.810040862463032 0.065186113410031 0.901277047586747 0.862989 0.632252 1.03266 1.27006 GeneID:57348,Genbank:NM_001201461.1,HGNC:HGNC:13476,MIM:605784 tweety family member 1 GO:0000278,GO:0005254,GO:0005381,GO:0005509,GO:0005886,GO:0006821,GO:0006826,GO:0016021,GO:0030868,GO:0031527,GO:0031589,GO:0032433,GO:0034220,GO:0034707,GO:0046847,GO:0072320,GO:0098609 mitotic cell cycle|chloride channel activity|iron ion transmembrane transporter activity|calcium ion binding|plasma membrane|chloride transport|iron ion transport|integral component of membrane|smooth endoplasmic reticulum membrane|filopodium membrane|cell-substrate adhesion|filopodium tip|ion transmembrane transport|chloride channel complex|filopodium assembly|volume-sensitive chloride channel activity|cell-cell adhesion TTYH2 10.1850579569502 10.6757096385841 9.69440627531622 0.908080736879421 -0.139107522572295 0.922273762622683 1 0.0896697 0.128716 0.104487 0.0587275 GeneID:94015,Genbank:NM_032646.5,HGNC:HGNC:13877,MIM:608855 tweety family member 2 GO:0005254,GO:0005886,GO:0034707 chloride channel activity|plasma membrane|chloride channel complex TTYH3 11628.7731285378 12477.9617981461 10779.5844589295 0.863889843013555 -0.211080732811102 0.0971036959370855 1 116.068 120.31 107.565 103.272 GeneID:80727,Genbank:NM_025250.2,HGNC:HGNC:22222,MIM:608919 tweety family member 3 GO:0005229,GO:0005254,GO:0005886,GO:0006821,GO:0034220,GO:0034707,GO:0070062 intracellular calcium activated chloride channel activity|chloride channel activity|plasma membrane|chloride transport|ion transmembrane transport|chloride channel complex|extracellular exosome TUB 184.951916335666 191.557032232971 178.34680043836 0.931037604620305 -0.103088655456039 0.649149900003982 1 0.954484 1.12839 1.05555 0.946451 GeneID:7275,Genbank:XM_005253109.3,HGNC:HGNC:12406,MIM:601197 tubby bipartite transcription factor GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0005929,GO:0006910,GO:0007605,GO:0009725,GO:0032403,GO:0035091,GO:0045494,GO:0050766,GO:0060041,GO:0097500,GO:1903546 extracellular region|nucleus|cytoplasm|cytosol|plasma membrane|cilium|phagocytosis, recognition|sensory perception of sound|response to hormone|protein complex binding|phosphatidylinositol binding|photoreceptor cell maintenance|positive regulation of phagocytosis|retina development in camera-type eye|receptor localization to non-motile cilium|protein localization to photoreceptor outer segment TUBA1A 19258.0221568023 15697.0539776846 22818.9903359201 1.45371165623564 0.539741139015273 2.98372592233003e-05 0.0103885552982691 259.912 260.694 367.658 388.984 GeneID:7846,Genbank:NM_006009.3,HGNC:HGNC:20766,MIM:602529 tubulin alpha 1a GO:0003924,GO:0005200,GO:0005525,GO:0005634,GO:0005874,GO:0005881,GO:0007017,GO:0019904,GO:0036464,GO:0043209,GO:0045121,GO:0046982,GO:0055037,GO:0070062 GTPase activity|structural constituent of cytoskeleton|GTP binding|nucleus|microtubule|cytoplasmic microtubule|microtubule-based process|protein domain specific binding|cytoplasmic ribonucleoprotein granule|myelin sheath|membrane raft|protein heterodimerization activity|recycling endosome|extracellular exosome hsa04145,hsa04210,hsa04530,hsa04540,hsa05130 Phagosome|Apoptosis|Tight junction|Gap junction|Pathogenic Escherichia coli infection TUBA1B 49814.118114504 49782.0096639732 49846.2265650347 1.00128996200626 0.00185982249690966 0.998903715993102 1 1100 1125.1 1099.76 1147.47 GeneID:10376,Genbank:NM_006082.2,HGNC:HGNC:18809,MIM:602530 tubulin alpha 1b GO:0000226,GO:0003725,GO:0003924,GO:0005200,GO:0005525,GO:0005874,GO:0005881,GO:0031625,GO:0043209,GO:0045121,GO:0070062,GO:0071353 microtubule cytoskeleton organization|double-stranded RNA binding|GTPase activity|structural constituent of cytoskeleton|GTP binding|microtubule|cytoplasmic microtubule|ubiquitin protein ligase binding|myelin sheath|membrane raft|extracellular exosome|cellular response to interleukin-4 hsa04145,hsa04210,hsa04530,hsa04540,hsa05130 Phagosome|Apoptosis|Tight junction|Gap junction|Pathogenic Escherichia coli infection TUBA1C 22731.5615061612 23507.4247469371 21955.6982653853 0.933989941550106 -0.0985210817339233 0.436934870073017 1 465.031 475.936 433.446 456.566 GeneID:84790,Genbank:NM_001303115.1,HGNC:HGNC:20768 tubulin alpha 1c GO:0003924,GO:0005198,GO:0005200,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0007017,GO:0015630,GO:0030705,GO:0031982,GO:0051301 GTPase activity|structural molecule activity|structural constituent of cytoskeleton|GTP binding|nucleus|cytoplasm|microtubule|microtubule-based process|microtubule cytoskeleton|cytoskeleton-dependent intracellular transport|vesicle|cell division hsa04145,hsa04210,hsa04530,hsa04540,hsa05130 Phagosome|Apoptosis|Tight junction|Gap junction|Pathogenic Escherichia coli infection TUBA3D 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0 0 0 0 GeneID:113457,Genbank:NM_080386.3,HGNC:HGNC:24071,MIM:617878 tubulin alpha 3d GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005874,GO:0005929,GO:0007017,GO:0015630,GO:0036064 GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule|cilium|microtubule-based process|microtubule cytoskeleton|ciliary basal body hsa04145,hsa04210,hsa04530,hsa04540,hsa05130 Phagosome|Apoptosis|Tight junction|Gap junction|Pathogenic Escherichia coli infection TUBA4A 403.323423994628 458.727105189722 347.919742799535 0.758446010413187 -0.398881608259993 0.0340818954083127 0.729079834868512 7.57305 7.25052 5.11428 6.33314 GeneID:7277,Genbank:NM_001278552.1,HGNC:HGNC:12407,MIM:191110 tubulin alpha 4a hsa04145,hsa04210,hsa04530,hsa04540,hsa05130 Phagosome|Apoptosis|Tight junction|Gap junction|Pathogenic Escherichia coli infection TUBA8 13.4221045035341 14.7305510231899 12.1136579838783 0.822349277009942 -0.282176813895205 0.833312688805715 1 0.386578 0.102588 0.144875 0.252966 GeneID:51807,Genbank:NM_018943.2,HGNC:HGNC:12410,MIM:605742 tubulin alpha 8 GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005874,GO:0007017,GO:0015630 GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule|microtubule-based process|microtubule cytoskeleton hsa04145,hsa04210,hsa04530,hsa04540,hsa05130 Phagosome|Apoptosis|Tight junction|Gap junction|Pathogenic Escherichia coli infection TUBAL3 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.021504 0 GeneID:79861,Genbank:NM_001171864.1,HGNC:HGNC:23534 tubulin alpha like 3 GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005874,GO:0007017 GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule|microtubule-based process hsa04145,hsa04210,hsa04530,hsa04540,hsa05130 Phagosome|Apoptosis|Tight junction|Gap junction|Pathogenic Escherichia coli infection TUBB 107593.252876295 107863.503957606 107323.001794984 0.994989017204242 -0.00724749376617505 0.944706162398738 1 1198.55 1250.81 1268.26 1233.88 GeneID:203068,Genbank:NM_178014.3,HGNC:HGNC:20778,MIM:191130 tubulin beta class I GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005874,GO:0007017 GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule|microtubule-based process hsa04145,hsa04540,hsa05130 Phagosome|Gap junction|Pathogenic Escherichia coli infection TUBB1 5.0934483364366 5.82302189369546 4.36387477917774 0.749417546223288 -0.416158338793617 0.866977631130857 1 0.0828322 0.00954532 0.0491301 0.00915827 GeneID:81027,Genbank:XM_017028085.1,HGNC:HGNC:16257,MIM:612901 tubulin beta 1 class VI GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005874,GO:0051225,GO:0070062 GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule|spindle assembly|extracellular exosome hsa04145,hsa04540,hsa05130 Phagosome|Gap junction|Pathogenic Escherichia coli infection TUBB2A 3422.41275423078 3252.23916778482 3592.58634067675 1.10465010576813 0.143589473136979 0.300461728308261 1 38.5911 40.8929 46.9601 44.5642 GeneID:7280,Genbank:NM_001069.2,HGNC:HGNC:12412,MIM:615101 tubulin beta 2A class IIa GO:0003924,GO:0005200,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0007017,GO:0070062,GO:1903561 GTPase activity|structural constituent of cytoskeleton|GTP binding|nucleus|cytoplasm|microtubule|microtubule-based process|extracellular exosome|extracellular vesicle hsa04145,hsa04540,hsa05130 Phagosome|Gap junction|Pathogenic Escherichia coli infection TUBB2B 433.595731774244 432.005534802093 435.185928746396 1.00736192869788 0.010582113261155 1 1 13.002 13.4563 14.3012 14.8658 GeneID:347733,Genbank:NM_178012.4,HGNC:HGNC:30829,MIM:612850 tubulin beta 2B class IIb GO:0001764,GO:0003924,GO:0005200,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0007017,GO:0015630,GO:0046982,GO:1902669 neuron migration|GTPase activity|structural constituent of cytoskeleton|GTP binding|nucleus|cytoplasm|microtubule|microtubule-based process|microtubule cytoskeleton|protein heterodimerization activity|positive regulation of axon guidance hsa04145,hsa04540,hsa05130 Phagosome|Gap junction|Pathogenic Escherichia coli infection TUBB3 4637.48576010792 4435.64419394453 4839.3273262713 1.09100890753994 0.125662880590245 0.357463357681674 1 88.5422 89.5449 97.3777 100.912 GeneID:10381,Genbank:NM_001197181.1,HGNC:HGNC:20772,MIM:602661 tubulin beta 3 class III GO:0000278,GO:0003924,GO:0005200,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0007017,GO:0007411,GO:0030424,GO:0030425,GO:0042277,GO:0043025,GO:0070062,GO:0071944 mitotic cell cycle|GTPase activity|structural constituent of cytoskeleton|GTP binding|nucleus|cytoplasm|microtubule|microtubule-based process|axon guidance|axon|dendrite|peptide binding|neuronal cell body|extracellular exosome|cell periphery hsa04145,hsa04540,hsa05130 Phagosome|Gap junction|Pathogenic Escherichia coli infection TUBB4A 274.820023303259 252.58461775847 297.055428848047 1.17606302190619 0.233965372211164 0.383049653774159 1 3.32623 4.29252 4.40056 5.01029 GeneID:10382,Genbank:NM_001289129.1,HGNC:HGNC:20774,MIM:602662 tubulin beta 4A class IVa GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005874,GO:0007017 GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule|microtubule-based process hsa04145,hsa04540,hsa05130 Phagosome|Gap junction|Pathogenic Escherichia coli infection TUBB4B 17712.0589020367 18347.9901346331 17076.1276694403 0.930681101534272 -0.103641182794209 0.405328523078318 1 476.674 498.802 455.979 476.154 GeneID:10383,Genbank:NM_006088.5,HGNC:HGNC:20771,MIM:602660 tubulin beta 4B class IVb GO:0000086,GO:0003725,GO:0003924,GO:0005200,GO:0005525,GO:0005576,GO:0005634,GO:0005829,GO:0005856,GO:0005874,GO:0006928,GO:0007017,GO:0010389,GO:0031012,GO:0035578,GO:0042267,GO:0042288,GO:0043209,GO:0043312,GO:0051082,GO:0070062,GO:0097711,GO:1903561 G2/M transition of mitotic cell cycle|double-stranded RNA binding|GTPase activity|structural constituent of cytoskeleton|GTP binding|extracellular region|nucleus|cytosol|cytoskeleton|microtubule|movement of cell or subcellular component|microtubule-based process|regulation of G2/M transition of mitotic cell cycle|extracellular matrix|azurophil granule lumen|natural killer cell mediated cytotoxicity|MHC class I protein binding|myelin sheath|neutrophil degranulation|unfolded protein binding|extracellular exosome|ciliary basal body-plasma membrane docking|extracellular vesicle hsa04145,hsa04540,hsa05130 Phagosome|Gap junction|Pathogenic Escherichia coli infection TUBB6 4572.45446866859 4483.24672951758 4661.6622078196 1.03979604270435 0.0563005696782172 0.686485029625479 1 50.3253 51.9799 55.9805 52.8391 GeneID:84617,Genbank:NM_001303524.1,HGNC:HGNC:20776,MIM:615103 tubulin beta 6 class V GO:0003924,GO:0005200,GO:0005525,GO:0005634,GO:0005737,GO:0005874,GO:0007017,GO:0070062 GTPase activity|structural constituent of cytoskeleton|GTP binding|nucleus|cytoplasm|microtubule|microtubule-based process|extracellular exosome hsa04145,hsa04540,hsa05130 Phagosome|Gap junction|Pathogenic Escherichia coli infection TUBB8 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0197698 0 GeneID:347688,Genbank:XM_011519460.2,HGNC:HGNC:20773,MIM:616768 tubulin beta 8 class VIII GO:0001556,GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005874,GO:0007056,GO:0070062,GO:0072687 oocyte maturation|GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|microtubule|spindle assembly involved in female meiosis|extracellular exosome|meiotic spindle hsa04145,hsa04540,hsa05130 Phagosome|Gap junction|Pathogenic Escherichia coli infection TUBD1 146.769239220748 147.172257063807 146.36622137769 0.994523181867299 -0.00792309489400259 1 1 1.53955 1.51258 1.86493 1.49377 GeneID:51174,Genbank:XM_017024720.1,HGNC:HGNC:16811,MIM:607344 tubulin delta 1 GO:0003924,GO:0005200,GO:0005525,GO:0005654,GO:0005814,GO:0005829,GO:0005874,GO:0007017,GO:0007275,GO:0007283,GO:0030154 GTPase activity|structural constituent of cytoskeleton|GTP binding|nucleoplasm|centriole|cytosol|microtubule|microtubule-based process|multicellular organism development|spermatogenesis|cell differentiation TUBE1 217.958671140424 240.620990357646 195.296351923203 0.811634727431405 -0.301097499850433 0.166112606429449 1 3.02541 3.89607 2.78859 2.99903 GeneID:51175,Genbank:NM_016262.4,HGNC:HGNC:20775,MIM:607345 tubulin epsilon 1 GO:0000242,GO:0003924,GO:0005200,GO:0005525,GO:0005874,GO:0007098 pericentriolar material|GTPase activity|structural constituent of cytoskeleton|GTP binding|microtubule|centrosome cycle TUBG1 3672.13245894908 3680.57102039722 3663.69389750094 0.995414536819762 -0.00663063891056195 0.954951465537218 1 53.6683 52.4286 54.2055 53.6689 GeneID:7283,Genbank:NM_001070.4,HGNC:HGNC:12417,MIM:191135 tubulin gamma 1 GO:0000086,GO:0000212,GO:0000226,GO:0000242,GO:0000794,GO:0000930,GO:0003924,GO:0005200,GO:0005525,GO:0005737,GO:0005813,GO:0005814,GO:0005827,GO:0005829,GO:0005881,GO:0007020,GO:0010389,GO:0031122,GO:0031252,GO:0036064,GO:0042802,GO:0045177,GO:0055037,GO:0097711,GO:0097730 G2/M transition of mitotic cell cycle|meiotic spindle organization|microtubule cytoskeleton organization|pericentriolar material|condensed nuclear chromosome|gamma-tubulin complex|GTPase activity|structural constituent of cytoskeleton|GTP binding|cytoplasm|centrosome|centriole|polar microtubule|cytosol|cytoplasmic microtubule|microtubule nucleation|regulation of G2/M transition of mitotic cell cycle|cytoplasmic microtubule organization|cell leading edge|ciliary basal body|identical protein binding|apical part of cell|recycling endosome|ciliary basal body-plasma membrane docking|non-motile cilium hsa05165 Human papillomavirus infection TUBG2 535.09910692166 519.678255476067 550.519958367254 1.05934768785531 0.0831761731069046 0.655474071212292 1 4.59886 5.13999 5.46876 5.2819 GeneID:27175,Genbank:NM_001320509.1,HGNC:HGNC:12419,MIM:605785 tubulin gamma 2 GO:0000242,GO:0000930,GO:0003924,GO:0005198,GO:0005525,GO:0005829,GO:0005874,GO:0005876,GO:0005881,GO:0007020,GO:0015630,GO:0031122 pericentriolar material|gamma-tubulin complex|GTPase activity|structural molecule activity|GTP binding|cytosol|microtubule|spindle microtubule|cytoplasmic microtubule|microtubule nucleation|microtubule cytoskeleton|cytoplasmic microtubule organization hsa05165 Human papillomavirus infection TUBGCP2 2462.28214469405 2343.47771312335 2581.08657626475 1.101391560846 0.139327459332074 0.311911783276526 1 20.1604 19.216 22.8401 22.1751 GeneID:10844,Genbank:NM_001256618.1,HGNC:HGNC:18599,MIM:617817 tubulin gamma complex associated protein 2 GO:0000922,GO:0000923,GO:0005200,GO:0005654,GO:0005813,GO:0005815,GO:0005829,GO:0005881,GO:0006461,GO:0007020,GO:0008275,GO:0016020,GO:0031122,GO:0043015,GO:0051298,GO:0051321,GO:0051415,GO:0090307 spindle pole|equatorial microtubule organizing center|structural constituent of cytoskeleton|nucleoplasm|centrosome|microtubule organizing center|cytosol|cytoplasmic microtubule|protein complex assembly|microtubule nucleation|gamma-tubulin small complex|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|centrosome duplication|meiotic cell cycle|interphase microtubule nucleation by interphase microtubule organizing center|mitotic spindle assembly TUBGCP3 668.066133910689 684.261743291167 651.87052453021 0.952662531438392 -0.0699628465893231 0.66703779768094 1 3.96282 4.46875 4.31935 3.53451 GeneID:10426,Genbank:XM_017020323.2,HGNC:HGNC:18598,MIM:617818 tubulin gamma complex associated protein 3 GO:0000923,GO:0005198,GO:0005200,GO:0005737,GO:0005813,GO:0005814,GO:0005819,GO:0005827,GO:0005829,GO:0007020,GO:0007338,GO:0008275,GO:0016020,GO:0031122,GO:0043015,GO:0051298,GO:0051321,GO:0051415,GO:0090307 equatorial microtubule organizing center|structural molecule activity|structural constituent of cytoskeleton|cytoplasm|centrosome|centriole|spindle|polar microtubule|cytosol|microtubule nucleation|single fertilization|gamma-tubulin small complex|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|centrosome duplication|meiotic cell cycle|interphase microtubule nucleation by interphase microtubule organizing center|mitotic spindle assembly TUBGCP4 1305.05955925661 1428.04060628067 1182.07851223254 0.827762534926271 -0.272711142162648 0.066349583299138 0.908334826576206 7.14841 6.74354 6.37626 5.19346 GeneID:27229,Genbank:NM_001286414.2,HGNC:HGNC:16691,MIM:609610 tubulin gamma complex associated protein 4 GO:0000922,GO:0000923,GO:0000930,GO:0005200,GO:0005813,GO:0005829,GO:0005874,GO:0006461,GO:0007020,GO:0008274,GO:0015630,GO:0016020,GO:0031122,GO:0043015,GO:0051298,GO:0051321,GO:0051415,GO:0055037,GO:0090307 spindle pole|equatorial microtubule organizing center|gamma-tubulin complex|structural constituent of cytoskeleton|centrosome|cytosol|microtubule|protein complex assembly|microtubule nucleation|gamma-tubulin ring complex|microtubule cytoskeleton|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|centrosome duplication|meiotic cell cycle|interphase microtubule nucleation by interphase microtubule organizing center|recycling endosome|mitotic spindle assembly TUBGCP5 917.701541495836 881.16051767013 954.242565321542 1.08293840473544 0.114951187812485 0.453118689182705 1 3.83478 3.57127 4.39034 3.99279 GeneID:114791,Genbank:NM_001354374.1,HGNC:HGNC:18600,MIM:608147 tubulin gamma complex associated protein 5 GO:0000922,GO:0000923,GO:0005200,GO:0005813,GO:0005829,GO:0005874,GO:0007020,GO:0008017,GO:0008274,GO:0031122,GO:0043015,GO:0051298,GO:0051321,GO:0051415,GO:0090307 spindle pole|equatorial microtubule organizing center|structural constituent of cytoskeleton|centrosome|cytosol|microtubule|microtubule nucleation|microtubule binding|gamma-tubulin ring complex|cytoplasmic microtubule organization|gamma-tubulin binding|centrosome duplication|meiotic cell cycle|interphase microtubule nucleation by interphase microtubule organizing center|mitotic spindle assembly TUBGCP6 592.714532035982 586.393575725459 599.035488346505 1.02155875020528 0.0307721763594527 0.871161089427781 1 3.49564 3.58177 3.93839 3.33879 GeneID:85378,Genbank:NM_020461.3,HGNC:HGNC:18127,MIM:610053 tubulin gamma complex associated protein 6 GO:0000922,GO:0000923,GO:0005200,GO:0005813,GO:0005829,GO:0005874,GO:0007020,GO:0008017,GO:0008274,GO:0016020,GO:0031122,GO:0043015,GO:0051298,GO:0051321,GO:0051415,GO:0070062,GO:0090307 spindle pole|equatorial microtubule organizing center|structural constituent of cytoskeleton|centrosome|cytosol|microtubule|microtubule nucleation|microtubule binding|gamma-tubulin ring complex|membrane|cytoplasmic microtubule organization|gamma-tubulin binding|centrosome duplication|meiotic cell cycle|interphase microtubule nucleation by interphase microtubule organizing center|extracellular exosome|mitotic spindle assembly TUFM 5201.55586806064 5114.20737685584 5288.90435926544 1.03415915107396 0.0484582251080734 0.729120210144738 1 79.0623 81.7309 81.4904 88.0582 GeneID:7284,Genbank:NM_003321.4,HGNC:HGNC:12420,MIM:602389 Tu translation elongation factor, mitochondrial GO:0003723,GO:0003746,GO:0003924,GO:0005525,GO:0005739,GO:0005743,GO:0006414,GO:0016020,GO:0042645,GO:0043209,GO:0045471,GO:0070062 RNA binding|translation elongation factor activity|GTPase activity|GTP binding|mitochondrion|mitochondrial inner membrane|translational elongation|membrane|mitochondrial nucleoid|myelin sheath|response to ethanol|extracellular exosome TUFT1 888.449651406373 868.323625670723 908.575677142022 1.04635604776987 0.0653738467550279 0.759790164317071 1 8.14954 8.76702 8.14287 10.0637 GeneID:7286,Genbank:XM_011509961.2,HGNC:HGNC:12422,MIM:600087 tuftelin 1 GO:0005576,GO:0005737,GO:0030282,GO:0030345,GO:0042476 extracellular region|cytoplasm|bone mineralization|structural constituent of tooth enamel|odontogenesis TULP2 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0 0 0 0 GeneID:7288,Genbank:XM_011527252.3,HGNC:HGNC:12424,MIM:602309 tubby like protein 2 GO:0005576,GO:0005737,GO:0005929,GO:0007601,GO:0032403,GO:0035091,GO:0097500,GO:1903546 extracellular region|cytoplasm|cilium|visual perception|protein complex binding|phosphatidylinositol binding|receptor localization to non-motile cilium|protein localization to photoreceptor outer segment TULP3 672.474269945904 646.103817523394 698.844722368413 1.08162914908502 0.113205936793527 0.488778422415755 1 6.92349 6.6612 7.62105 7.14253 GeneID:7289,Genbank:NM_003324.4,HGNC:HGNC:12425,MIM:604730 tubby like protein 3 GO:0001843,GO:0005546,GO:0005576,GO:0005634,GO:0005730,GO:0005886,GO:0005929,GO:0005930,GO:0006355,GO:0007186,GO:0007420,GO:0008277,GO:0009952,GO:0019899,GO:0021914,GO:0021953,GO:0031076,GO:0032403,GO:0035091,GO:0042733,GO:0045879,GO:0048702,GO:0060348,GO:0060434,GO:0060831,GO:0061548,GO:0097500,GO:0097546,GO:1901621,GO:1903546 neural tube closure|phosphatidylinositol-4,5-bisphosphate binding|extracellular region|nucleus|nucleolus|plasma membrane|cilium|axoneme|regulation of transcription, DNA-templated|G-protein coupled receptor signaling pathway|brain development|regulation of G-protein coupled receptor protein signaling pathway|anterior/posterior pattern specification|enzyme binding|negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning|central nervous system neuron differentiation|embryonic camera-type eye development|protein complex binding|phosphatidylinositol binding|embryonic digit morphogenesis|negative regulation of smoothened signaling pathway|embryonic neurocranium morphogenesis|bone development|bronchus morphogenesis|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|ganglion development|receptor localization to non-motile cilium|ciliary base|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|protein localization to photoreceptor outer segment TULP4 1019.98264242666 1055.10338839711 984.861896456218 0.933426910847479 -0.0993910338564167 0.526793722606077 1 3.62881 3.37447 3.73756 2.92634 GeneID:56995,Genbank:XM_011535946.1,HGNC:HGNC:15530 tubby like protein 4 GO:0005737,GO:0005829,GO:0005929,GO:0016567,GO:0035091,GO:0043687,GO:0061512 cytoplasm|cytosol|cilium|protein ubiquitination|phosphatidylinositol binding|post-translational protein modification|protein localization to cilium TUSC2 1294.81313522164 1426.14999825946 1163.47627218382 0.815816199981615 -0.293683939312348 0.0976163435100425 1 32.9318 36.1584 25.9288 31.7361 GeneID:11334,Genbank:NM_007275.2,HGNC:HGNC:17034,MIM:607052 tumor suppressor 2, mitochondrial calcium regulator GO:0001779,GO:0005739,GO:0006909,GO:0006954,GO:0007049,GO:0007267,GO:0008283,GO:0032618,GO:0032700,GO:0032733,GO:0048469,GO:0051881,GO:0052567,GO:0070945,GO:0071609,GO:2000377 natural killer cell differentiation|mitochondrion|phagocytosis|inflammatory response|cell cycle|cell-cell signaling|cell proliferation|interleukin-15 production|negative regulation of interleukin-17 production|positive regulation of interleukin-10 production|cell maturation|regulation of mitochondrial membrane potential|response to defense-related host reactive oxygen species production|neutrophil mediated killing of gram-negative bacterium|chemokine (C-C motif) ligand 5 production|regulation of reactive oxygen species metabolic process TUSC3 1283.56588015652 1226.63513673473 1340.49662357832 1.09282425020588 0.128061403074089 0.380801641607898 1 4.86561 5.13961 5.80964 5.1199 GeneID:7991,Genbank:NM_006765.3,HGNC:HGNC:30242,MIM:601385 tumor suppressor candidate 3 GO:0005739,GO:0005789,GO:0005886,GO:0005887,GO:0006487,GO:0008250,GO:0015095,GO:0015693,GO:0018279,GO:0050890,GO:0055085 mitochondrion|endoplasmic reticulum membrane|plasma membrane|integral component of plasma membrane|protein N-linked glycosylation|oligosaccharyltransferase complex|magnesium ion transmembrane transporter activity|magnesium ion transport|protein N-linked glycosylation via asparagine|cognition|transmembrane transport hsa00510,hsa04141 N-Glycan biosynthesis|Protein processing in endoplasmic reticulum TUT1 368.543509887645 362.992728021222 374.094291754068 1.03058343287857 0.0434613057774177 0.882735062094653 1 4.89447 5.66764 4.93085 5.98657 GeneID:64852,Genbank:NM_022830.2,HGNC:HGNC:26184,MIM:610641 terminal uridylyl transferase 1, U6 snRNA-specific GO:0003723,GO:0003730,GO:0004652,GO:0005524,GO:0005634,GO:0005730,GO:0005829,GO:0006378,GO:0016180,GO:0016607,GO:0019899,GO:0046872,GO:0050265,GO:0098789 RNA binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|ATP binding|nucleus|nucleolus|cytosol|mRNA polyadenylation|snRNA processing|nuclear speck|enzyme binding|metal ion binding|RNA uridylyltransferase activity|pre-mRNA cleavage required for polyadenylation TVP23A 23.0756994608439 25.8002795143615 20.3511194073262 0.788794532090162 -0.342278543873552 0.594294810132323 1 0.0878737 0.0401144 0.024948 0.0388044 GeneID:780776,Genbank:XM_006720944.3,HGNC:HGNC:20398 trans-golgi network vesicle protein 23 homolog A GO:0009306,GO:0016192,GO:0030173 protein secretion|vesicle-mediated transport|integral component of Golgi membrane TVP23B 400.883500367923 407.759679386156 394.00732134969 0.96627337441218 -0.049496686247643 0.842853666506634 1 5.88375 4.46028 5.14763 4.82366 GeneID:51030,Genbank:NM_016078.5,HGNC:HGNC:20399 trans-golgi network vesicle protein 23 homolog B GO:0009306,GO:0016192,GO:0030173 protein secretion|vesicle-mediated transport|integral component of Golgi membrane TVP23C 37.9671079594859 26.982336072124 48.9518798468479 1.81421948477697 0.859349004071694 0.0676582442288202 0.916343630061028 0.22319 0.367755 0.581621 0.496045 GeneID:201158,Genbank:NM_145301.2,HGNC:HGNC:30453 trans-golgi network vesicle protein 23 homolog C GO:0009306,GO:0016192,GO:0030173 protein secretion|vesicle-mediated transport|integral component of Golgi membrane TWF1 870.417263157593 983.74506881007 757.089457505117 0.769599240198363 -0.377820720107103 0.158514379889879 1 12.8093 10.6283 10.1831 7.63433 GeneID:5756,Genbank:NM_002822.4,HGNC:HGNC:9620,MIM:610932 twinfilin actin binding protein 1 TWF2 2132.64999203427 2249.38807195096 2015.91191211758 0.896204588819181 -0.158099981374263 0.257580257673412 1 63.5579 67.8597 56.2452 61.8653 GeneID:11344,Genbank:NM_007284.3,HGNC:HGNC:9621,MIM:607433 twinfilin actin binding protein 2 TWIST1 382.250814454184 358.399788959974 406.101839948394 1.13309731885402 0.180271775896776 0.394800681620752 1 11.8095 15.0688 15.1248 16.056 GeneID:7291,Genbank:NM_000474.3,HGNC:HGNC:12428,MIM:601622 twist family bHLH transcription factor 1 hsa05205 Proteoglycans in cancer TWIST2 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0251473 0 0 0 GeneID:117581,Genbank:NM_001271893.3,HGNC:HGNC:20670,MIM:607556 twist family bHLH transcription factor 2 GO:0000122,GO:0001076,GO:0001649,GO:0003677,GO:0003682,GO:0003700,GO:0005634,GO:0005667,GO:0005730,GO:0005737,GO:0006351,GO:0006357,GO:0008285,GO:0010838,GO:0019904,GO:0032720,GO:0043066,GO:0043392,GO:0044092,GO:0045638,GO:0045668,GO:0045892,GO:0046983,GO:0048701,GO:0060325,GO:0061303 negative regulation of transcription from RNA polymerase II promoter|transcription factor activity, RNA polymerase II transcription factor binding|osteoblast differentiation|DNA binding|chromatin binding|DNA binding transcription factor activity|nucleus|transcription factor complex|nucleolus|cytoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|negative regulation of cell proliferation|positive regulation of keratinocyte proliferation|protein domain specific binding|negative regulation of tumor necrosis factor production|negative regulation of apoptotic process|negative regulation of DNA binding|negative regulation of molecular function|negative regulation of myeloid cell differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|protein dimerization activity|embryonic cranial skeleton morphogenesis|face morphogenesis|cornea development in camera-type eye hsa05205 Proteoglycans in cancer TWISTNB 399.745142371512 438.383220680083 361.107064062942 0.823724647815537 -0.279765936628458 0.482758871915129 1 5.67655 4.14754 4.90382 3.27287 GeneID:221830,Genbank:NM_001002926.1,HGNC:HGNC:18027,MIM:608312 TWIST neighbor GO:0003899,GO:0005654,GO:0005736,GO:0006361,GO:0006362,GO:0006363,GO:0045815,GO:1990830 DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|DNA-directed RNA polymerase I complex|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|positive regulation of gene expression, epigenetic|cellular response to leukemia inhibitory factor hsa00230,hsa00240,hsa03020 Purine metabolism|Pyrimidine metabolism|RNA polymerase TWNK 989.707390535517 1079.4354877073 899.97929336373 0.833749958763413 -0.262313309944647 0.0815284290165157 0.958003902515418 9.07215 9.89507 8.50385 7.74136 GeneID:56652,Genbank:XM_011539975.2,HGNC:HGNC:1160,MIM:606075 twinkle mtDNA helicase TWSG1 989.464653511777 1020.72093802008 958.208369003472 0.938756454689891 -0.0911771725618296 0.698083684669595 1 15.3148 13.2659 15.2668 11.5142 GeneID:57045,Genbank:NM_020648.5,HGNC:HGNC:12429,MIM:605049 twisted gastrulation BMP signaling modulator 1 GO:0001503,GO:0001707,GO:0001818,GO:0007179,GO:0007435,GO:0010862,GO:0030097,GO:0030154,GO:0030509,GO:0030513,GO:0030514,GO:0030900,GO:0043010,GO:0045668,GO:0050431,GO:0070062,GO:2000515,GO:2000562 ossification|mesoderm formation|negative regulation of cytokine production|transforming growth factor beta receptor signaling pathway|salivary gland morphogenesis|positive regulation of pathway-restricted SMAD protein phosphorylation|hemopoiesis|cell differentiation|BMP signaling pathway|positive regulation of BMP signaling pathway|negative regulation of BMP signaling pathway|forebrain development|camera-type eye development|negative regulation of osteoblast differentiation|transforming growth factor beta binding|extracellular exosome|negative regulation of CD4-positive, alpha-beta T cell activation|negative regulation of CD4-positive, alpha-beta T cell proliferation TXK 11.9458325888008 13.7121905996982 10.1794745779034 0.742366765097871 -0.429795970765835 0.623424030673301 1 0.0322339 0.0671628 0.0622678 0.0289181 GeneID:7294,Genbank:XM_017008581.2,HGNC:HGNC:12434,MIM:600058 TXK tyrosine kinase GO:0000978,GO:0001012,GO:0001077,GO:0001816,GO:0002250,GO:0004715,GO:0005524,GO:0005634,GO:0005737,GO:0006357,GO:0006468,GO:0007169,GO:0007202,GO:0007229,GO:0010543,GO:0030154,GO:0031234,GO:0032729,GO:0038083,GO:0042127,GO:0042246,GO:0045944,GO:0046777,GO:0050852,GO:0060335 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|cytokine production|adaptive immune response|non-membrane spanning protein tyrosine kinase activity|ATP binding|nucleus|cytoplasm|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|activation of phospholipase C activity|integrin-mediated signaling pathway|regulation of platelet activation|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|positive regulation of interferon-gamma production|peptidyl-tyrosine autophosphorylation|regulation of cell proliferation|tissue regeneration|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway hsa04670 Leukocyte transendothelial migration TXLNA 4211.37142806728 4103.78469592941 4318.95816020515 1.05243293209051 0.0737282982575625 0.595214510170889 1 27.9245 29.5075 31.2996 30.8027 GeneID:200081,Genbank:XM_017000563.1,HGNC:HGNC:30685,MIM:608676 taxilin alpha GO:0005125,GO:0005576,GO:0005737,GO:0005829,GO:0006887,GO:0008283,GO:0016020,GO:0019221,GO:0019905,GO:0030372,GO:0042113 cytokine activity|extracellular region|cytoplasm|cytosol|exocytosis|cell proliferation|membrane|cytokine-mediated signaling pathway|syntaxin binding|high molecular weight B cell growth factor receptor binding|B cell activation TXLNB 15.4784522553923 17.3828217868244 13.5740827239602 0.780890633892873 -0.356807586198466 0.646585696116697 1 0.0843919 0.0914752 0.0919933 0.0375129 GeneID:167838,Genbank:XM_024446341.1,HGNC:HGNC:21617,MIM:611438 taxilin beta GO:0005737,GO:0019905 cytoplasm|syntaxin binding TXLNG 293.192861691312 336.297532596353 250.088190786271 0.743651577980633 -0.427301259115821 0.0362790019766763 0.739899327172153 1.44483 1.21782 1.07972 0.83739 GeneID:55787,Genbank:NM_018360.2,HGNC:HGNC:18578,MIM:300677 taxilin gamma GO:0005829,GO:0006351,GO:0006355,GO:0007049,GO:0010564,GO:0019905,GO:0030500,GO:0031965,GO:0046982,GO:0051726 cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|regulation of cell cycle process|syntaxin binding|regulation of bone mineralization|nuclear membrane|protein heterodimerization activity|regulation of cell cycle TXN 3857.43943527108 3970.46565728679 3744.41321325538 0.943066515733098 -0.0845685652022173 0.559132302249403 1 235.001 239.896 211.493 240.969 GeneID:7295,Genbank:NM_001244938.1,HGNC:HGNC:12435,MIM:187700 thioredoxin hsa04621,hsa05418 NOD-like receptor signaling pathway|Fluid shear stress and atherosclerosis TXN2 1846.55019684237 1855.00236523999 1838.09802844474 0.990887161595038 -0.0132073166642341 0.914986323990818 1 31.0265 32.9915 30.7904 33.0795 GeneID:25828,Genbank:XM_005261508.1,HGNC:HGNC:17772,MIM:609063 thioredoxin 2 GO:0001666,GO:0005730,GO:0005739,GO:0005759,GO:0006662,GO:0008113,GO:0009725,GO:0009749,GO:0014070,GO:0015035,GO:0030425,GO:0031669,GO:0032403,GO:0033743,GO:0034599,GO:0042493,GO:0043025,GO:0045454,GO:0048678 response to hypoxia|nucleolus|mitochondrion|mitochondrial matrix|glycerol ether metabolic process|peptide-methionine (S)-S-oxide reductase activity|response to hormone|response to glucose|response to organic cyclic compound|protein disulfide oxidoreductase activity|dendrite|cellular response to nutrient levels|protein complex binding|peptide-methionine (R)-S-oxide reductase activity|cellular response to oxidative stress|response to drug|neuronal cell body|cell redox homeostasis|response to axon injury hsa04621,hsa05418 NOD-like receptor signaling pathway|Fluid shear stress and atherosclerosis TXNDC11 751.374937790899 735.065472960462 767.684402621335 1.04437554321454 0.0626405786804488 0.718517017086677 1 7.91492 8.50642 9.34049 8.04876 GeneID:51061,Genbank:NM_001324025.1,HGNC:HGNC:28030,MIM:617792 thioredoxin domain containing 11 GO:0003756,GO:0005783,GO:0005789,GO:0006457,GO:0016021,GO:0034976,GO:0045454 protein disulfide isomerase activity|endoplasmic reticulum|endoplasmic reticulum membrane|protein folding|integral component of membrane|response to endoplasmic reticulum stress|cell redox homeostasis TXNDC12 2487.44941744307 2323.08885334159 2651.80998154455 1.14150174571675 0.19093306590074 0.171379049194207 1 37.7796 40.6158 45.0961 45.4702 GeneID:51060,Genbank:NM_015913.3,HGNC:HGNC:24626,MIM:609448 thioredoxin domain containing 12 GO:0005788,GO:0015037,GO:0019153,GO:0030154,GO:0045454,GO:1902236 endoplasmic reticulum lumen|peptide disulfide oxidoreductase activity|protein-disulfide reductase (glutathione) activity|cell differentiation|cell redox homeostasis|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway hsa00480 Glutathione metabolism TXNDC15 1362.82083790225 1270.84640711451 1454.79526869 1.14474515609888 0.195026460371219 0.179510969814138 1 15.5279 15.2943 17.2206 18.2468 GeneID:79770,Genbank:NM_024715.3,HGNC:HGNC:20652,MIM:617778 thioredoxin domain containing 15 GO:0005623,GO:0016021,GO:0045454 cell|integral component of membrane|cell redox homeostasis TXNDC16 147.774821392756 153.533376634145 142.016266151366 0.924986275067584 -0.112496135786882 0.686772762959753 1 1.26243 1.14601 1.33652 0.926355 GeneID:57544,Genbank:NM_001160047.1,HGNC:HGNC:19965,MIM:616179 thioredoxin domain containing 16 GO:0005788,GO:0045454,GO:0070062 endoplasmic reticulum lumen|cell redox homeostasis|extracellular exosome TXNDC17 1153.08724281478 1211.05195542402 1095.12253020553 0.904273780576243 -0.145168461538196 0.556333643626039 1 20.1203 25.5132 18.3447 22.8398 GeneID:84817,Genbank:NM_032731.3,HGNC:HGNC:28218,MIM:616967 thioredoxin domain containing 17 GO:0004601,GO:0005829,GO:0033209,GO:0047134,GO:0070062 peroxidase activity|cytosol|tumor necrosis factor-mediated signaling pathway|protein-disulfide reductase activity|extracellular exosome TXNDC2 9.76408943130844 9.34957425676688 10.17860460585 1.08867038501599 0.12256721770598 0.939158334869897 1 0.131184 0.0755244 0.111528 0.0942388 GeneID:84203,Genbank:NM_001098529.1,HGNC:HGNC:16470,MIM:617790 thioredoxin domain containing 2 GO:0004791,GO:0005737,GO:0006662,GO:0007275,GO:0007283,GO:0015035,GO:0016671,GO:0030154,GO:0034599,GO:0045454,GO:0047134 thioredoxin-disulfide reductase activity|cytoplasm|glycerol ether metabolic process|multicellular organism development|spermatogenesis|protein disulfide oxidoreductase activity|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|cell differentiation|cellular response to oxidative stress|cell redox homeostasis|protein-disulfide reductase activity TXNDC5 9346.31948658716 9603.56426891438 9089.07470425995 0.946427227407664 -0.0794365162635705 0.532384074946509 1 114.373 120.234 114.072 111.707 GeneID:81567,Genbank:NM_030810.4,HGNC:HGNC:21073,MIM:616412 thioredoxin domain containing 5 GO:0003756,GO:0005576,GO:0005783,GO:0005788,GO:0006457,GO:0034976,GO:0035578,GO:0043066,GO:0043202,GO:0043277,GO:0043312,GO:0045454,GO:0070062 protein disulfide isomerase activity|extracellular region|endoplasmic reticulum|endoplasmic reticulum lumen|protein folding|response to endoplasmic reticulum stress|azurophil granule lumen|negative regulation of apoptotic process|lysosomal lumen|apoptotic cell clearance|neutrophil degranulation|cell redox homeostasis|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum TXNDC9 429.81886774741 467.076919332358 392.560816162462 0.840462887191237 -0.250743979943815 0.173487234116237 1 7.35274 7.06349 6.61125 6.04854 GeneID:10190,Genbank:XM_017003147.2,HGNC:HGNC:24110,MIM:612564 thioredoxin domain containing 9 GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0008616,GO:0030496,GO:0045296,GO:0045454 nucleus|cytoplasm|centrosome|cytosol|queuosine biosynthetic process|midbody|cadherin binding|cell redox homeostasis TXNIP 212.268483590267 226.351084771089 198.185882409444 0.875568511676765 -0.191708023493947 0.397218054730691 1 2.43543 2.57698 1.91515 2.61007 GeneID:10628,Genbank:NM_006472.5,HGNC:HGNC:16952,MIM:606599 thioredoxin interacting protein GO:0000122,GO:0004857,GO:0005634,GO:0005737,GO:0005758,GO:0005829,GO:0006351,GO:0006606,GO:0007049,GO:0009612,GO:0009749,GO:0030216,GO:0031625,GO:0032355,GO:0032570,GO:0042127,GO:0042542,GO:0043065,GO:0048008,GO:0051592,GO:0051782,GO:0071228 negative regulation of transcription from RNA polymerase II promoter|enzyme inhibitor activity|nucleus|cytoplasm|mitochondrial intermembrane space|cytosol|transcription, DNA-templated|protein import into nucleus|cell cycle|response to mechanical stimulus|response to glucose|keratinocyte differentiation|ubiquitin protein ligase binding|response to estradiol|response to progesterone|regulation of cell proliferation|response to hydrogen peroxide|positive regulation of apoptotic process|platelet-derived growth factor receptor signaling pathway|response to calcium ion|negative regulation of cell division|cellular response to tumor cell hsa04621 NOD-like receptor signaling pathway TXNL1 712.739265861951 741.66570690337 683.812824820531 0.921996013103548 -0.117167582723179 0.478097409326346 1 9.42146 8.93993 8.58961 8.37496 GeneID:9352,Genbank:NM_004786.2,HGNC:HGNC:12436,MIM:603049 thioredoxin like 1 GO:0000502,GO:0004791,GO:0005634,GO:0005737,GO:0005829,GO:0015035,GO:0015036,GO:0016671,GO:0034599,GO:0045454,GO:0047134,GO:0070062 proteasome complex|thioredoxin-disulfide reductase activity|nucleus|cytoplasm|cytosol|protein disulfide oxidoreductase activity|disulfide oxidoreductase activity|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|cellular response to oxidative stress|cell redox homeostasis|protein-disulfide reductase activity|extracellular exosome TXNL4A 945.990949494052 968.825463690705 923.1564352974 0.952861449141385 -0.0696616406348235 0.63441963555195 1 21.4504 22.3953 21.0173 22.4812 GeneID:10907,Genbank:NM_001305564.1,HGNC:HGNC:30551,MIM:611595 thioredoxin like 4A GO:0000245,GO:0000375,GO:0000398,GO:0005634,GO:0005654,GO:0005681,GO:0005682,GO:0005829,GO:0007049,GO:0031965,GO:0046540,GO:0051301 spliceosomal complex assembly|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|nucleus|nucleoplasm|spliceosomal complex|U5 snRNP|cytosol|cell cycle|nuclear membrane|U4/U6 x U5 tri-snRNP complex|cell division hsa03040 Spliceosome TXNL4B 396.539574905149 425.268996688529 367.810153121769 0.864888237764383 -0.209414377444825 0.246549507619162 1 4.61104 5.61928 4.51498 4.55027 GeneID:54957,Genbank:XM_017023377.2,HGNC:HGNC:26041,MIM:617722 thioredoxin like 4B GO:0000245,GO:0005654,GO:0005681,GO:0005682,GO:0005829,GO:0007049,GO:0046540 spliceosomal complex assembly|nucleoplasm|spliceosomal complex|U5 snRNP|cytosol|cell cycle|U4/U6 x U5 tri-snRNP complex TXNRD1 15060.8820190051 16042.4575408083 14079.306497202 0.87762778622836 -0.188318891822576 0.150703128867254 1 153.185 146.139 140.256 125.371 GeneID:7296,Genbank:NM_001093771.2,HGNC:HGNC:12437,MIM:601112 thioredoxin reductase 1 hsa00450,hsa05200,hsa05225 Selenocompound metabolism|Pathways in cancer|Hepatocellular carcinoma TXNRD2 707.625730105914 733.911825367169 681.339634844659 0.928367157054311 -0.107232609681258 0.505386382647919 1 5.10863 4.8835 4.24863 4.97399 GeneID:10587,Genbank:NM_001352300.1,HGNC:HGNC:18155,MIM:606448 thioredoxin reductase 2 GO:0000305,GO:0004791,GO:0005739,GO:0005759,GO:0005829,GO:0009055,GO:0034599,GO:0045454,GO:0050660 response to oxygen radical|thioredoxin-disulfide reductase activity|mitochondrion|mitochondrial matrix|cytosol|electron transfer activity|cellular response to oxidative stress|cell redox homeostasis|flavin adenine dinucleotide binding hsa00450,hsa05200,hsa05225 Selenocompound metabolism|Pathways in cancer|Hepatocellular carcinoma TXNRD3 70.0206792280426 73.163700714847 66.8776577412383 0.914082490194032 -0.129603729577956 0.694383100432022 1 0.941727 1.34368 1.06278 0.984395 GeneID:114112,Genbank:NM_001173513.1,HGNC:HGNC:20667,MIM:606235 thioredoxin reductase 3 GO:0000305,GO:0004791,GO:0005634,GO:0005739,GO:0005783,GO:0007275,GO:0007283,GO:0009055,GO:0015035,GO:0030154,GO:0045454,GO:0050660 response to oxygen radical|thioredoxin-disulfide reductase activity|nucleus|mitochondrion|endoplasmic reticulum|multicellular organism development|spermatogenesis|electron transfer activity|protein disulfide oxidoreductase activity|cell differentiation|cell redox homeostasis|flavin adenine dinucleotide binding hsa00450,hsa05200,hsa05225 Selenocompound metabolism|Pathways in cancer|Hepatocellular carcinoma TYK2 2102.17496502369 2020.68268271945 2183.66724732793 1.08065816864879 0.111910245196191 0.439726359589709 1 14.0558 14.4372 15.3733 16.0209 GeneID:7297,Genbank:XM_011528245.1,HGNC:HGNC:12440,MIM:176941 tyrosine kinase 2 hsa04217,hsa04380,hsa04621,hsa04630,hsa04658,hsa04659,hsa05145,hsa05160,hsa05162,hsa05164,hsa05165,hsa05167,hsa05168,hsa05169 Necroptosis|Osteoclast differentiation|NOD-like receptor signaling pathway|Jak-STAT signaling pathway|Th1 and Th2 cell differentiation|Th17 cell differentiation|Toxoplasmosis|Hepatitis C|Measles|Influenza A|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Herpes simplex infection|Epstein-Barr virus infection TYMP 5.05042516112185 6.7071121482403 3.3937381740034 0.505990968839516 -0.982816459625325 0.504578158949251 1 0.327463 0.428013 0.26626 0.186257 GeneID:1890,Genbank:NM_001953.4,HGNC:HGNC:3148,MIM:131222 thymidine phosphorylase hsa00240,hsa00983,hsa05219 Pyrimidine metabolism|Drug metabolism - other enzymes|Bladder cancer TYMS 10543.1689399685 10138.5913149794 10947.7465649577 1.07980943553596 0.110776728439407 0.393314407280355 1 180.451 181.841 204.778 192.097 GeneID:7298,Genbank:NM_001354867.1,HGNC:HGNC:12441,MIM:188350 thymidylate synthetase hsa00240,hsa00670,hsa01523 Pyrimidine metabolism|One carbon pool by folate|Antifolate resistance TYMSOS 202.97959582987 187.38652098878 218.572670670959 1.16642685673238 0.222095842908971 0.336976590839549 1 5.75404 6.98214 9.20665 9.74912 GeneID:494514,Genbank:NM_001012716.2,HGNC:HGNC:29553 TYMS opposite strand TYRO3 1732.22533464215 1541.87245870458 1922.57821057971 1.24691131210358 0.318358855593795 0.0277195359129434 0.6676031386191 8.58562 9.17222 11.8457 10.9725 GeneID:7301,Genbank:NM_006293.3,HGNC:HGNC:12446,MIM:600341 TYRO3 protein tyrosine kinase TYRP1 5.21417685691103 5.58289052027075 4.84546319355132 0.86791298807635 -0.204377681207327 0.944562697063481 1 0.0448162 0.0850002 0.0573525 0.0799889 GeneID:7306,Genbank:NM_000550.2,HGNC:HGNC:12450,MIM:115501 tyrosinase related protein 1 hsa00350,hsa04916 Tyrosine metabolism|Melanogenesis TYSND1 731.210450613507 752.948174804352 709.472726422661 0.942259706794578 -0.0858033428355988 0.574643381950904 1 10.2297 11.2986 10.5839 10.5718 GeneID:219743,Genbank:NM_001040273.2,HGNC:HGNC:28531,MIM:611017 trypsin domain containing 1 GO:0002020,GO:0004252,GO:0005777,GO:0006508,GO:0016020,GO:0016485,GO:0031998,GO:0042802,GO:0051260 protease binding|serine-type endopeptidase activity|peroxisome|proteolysis|membrane|protein processing|regulation of fatty acid beta-oxidation|identical protein binding|protein homooligomerization TYW1 542.303580519322 561.236238091363 523.37092294728 0.932532305339273 -0.100774389953304 0.570883246634563 1 2.85786 2.73098 2.55273 2.82336 GeneID:55253,Genbank:NM_018264.3,HGNC:HGNC:25598,MIM:611243 tRNA-yW synthesizing protein 1 homolog GO:0008033,GO:0010181,GO:0046872,GO:0051539,GO:0055114,GO:0102521 tRNA processing|FMN binding|metal ion binding|4 iron, 4 sulfur cluster binding|oxidation-reduction process|tRNA-4-demethylwyosine synthase activity TYW1B 39.8858110490718 42.9429699277613 36.8286521703822 0.857617724911329 -0.221593371720618 0.633520061340924 1 0.21706 0.25768 0.215807 0.244041 GeneID:441250,Genbank:NM_001145440.2,HGNC:HGNC:33908 tRNA-yW synthesizing protein 1 homolog B GO:0008033,GO:0010181,GO:0046872,GO:0051539,GO:0055114,GO:0102521 tRNA processing|FMN binding|metal ion binding|4 iron, 4 sulfur cluster binding|oxidation-reduction process|tRNA-4-demethylwyosine synthase activity TYW3 234.561496316868 255.850404437046 213.27258819669 0.833583158353643 -0.2626019650698 0.402728235709787 1 2.90175 2.38341 2.82893 1.76318 GeneID:127253,Genbank:NM_001162916.1,HGNC:HGNC:24757,MIM:611245 tRNA-yW synthesizing protein 3 homolog GO:0008033,GO:0008168 tRNA processing|methyltransferase activity TYW5 126.747615914309 125.042608736572 128.452623092047 1.02727081904264 0.0388165689822964 0.909945093359362 1 0.863431 0.695165 1.08105 0.644623 GeneID:129450,Genbank:NM_001039693.2,HGNC:HGNC:26754 tRNA-yW synthesizing protein 5 GO:0000049,GO:0005506,GO:0005737,GO:0006400,GO:0016706,GO:0031591,GO:0042803,GO:0102524 tRNA binding|iron ion binding|cytoplasm|tRNA modification|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|wybutosine biosynthetic process|protein homodimerization activity|tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity U2AF1 140.449653584128 106.959010139689 173.940297028566 1.62623323459519 0.701534183774087 0.237305458911965 1 0.0613619 0.903961 0.916759 0.320613 GeneID:7307,Genbank:XM_024452129.1,HGNC:HGNC:12453,MIM:191317 U2 small nuclear RNA auxiliary factor 1 GO:0000398,GO:0005681,GO:0016607,GO:0030628,GO:0046872,GO:0050733,GO:0089701 mRNA splicing, via spliceosome|spliceosomal complex|nuclear speck|pre-mRNA 3'-splice site binding|metal ion binding|RS domain binding|U2AF hsa03040,hsa05131 Spliceosome|Shigellosis U2AF1L4 149.875170387174 152.428772316391 147.321568457956 0.966494489322303 -0.0491665882656989 0.846080192925705 1 1.86254 2.84807 2.06691 2.19295 GeneID:199746,Genbank:NM_144987.3,HGNC:HGNC:23020,MIM:601080 U2 small nuclear RNA auxiliary factor 1 like 4 GO:0000398,GO:0005654,GO:0005681,GO:0005737,GO:0006369,GO:0006405,GO:0006406,GO:0016607,GO:0030628,GO:0031124,GO:0046872,GO:0089701 mRNA splicing, via spliceosome|nucleoplasm|spliceosomal complex|cytoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|nuclear speck|pre-mRNA 3'-splice site binding|mRNA 3'-end processing|metal ion binding|U2AF hsa03040,hsa05131 Spliceosome|Shigellosis U2AF1L5 51.8775793279191 50.918382528026 52.8367761278123 1.0376758550555 0.053355850886107 0.911799965551894 1 0.210574 0.187933 0.280738 0.28817 GeneID:102724594,Genbank:XM_024452037.1,HGNC:HGNC:51830 U2 small nuclear RNA auxiliary factor 1 like 5 GO:0000398,GO:0005681,GO:0016607,GO:0030628,GO:0046872,GO:0050733,GO:0089701 mRNA splicing, via spliceosome|spliceosomal complex|nuclear speck|pre-mRNA 3'-splice site binding|metal ion binding|RS domain binding|U2AF hsa03040,hsa05131 Spliceosome|Shigellosis U2AF2 13425.923197025 14052.2219106503 12799.6244833998 0.910861254880904 -0.134696779761797 0.287410447643321 1 122.326 126.679 115.502 118.384 GeneID:11338,Genbank:NM_007279.2,HGNC:HGNC:23156,MIM:191318 U2 small nuclear RNA auxiliary factor 2 GO:0000243,GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0005681,GO:0006369,GO:0006397,GO:0006405,GO:0006406,GO:0008187,GO:0016607,GO:0019899,GO:0030628,GO:0031124,GO:0031397,GO:0033120,GO:0048025,GO:0070742,GO:0071004,GO:0089701,GO:1903146,GO:1903955 commitment complex|mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|spliceosomal complex|termination of RNA polymerase II transcription|mRNA processing|RNA export from nucleus|mRNA export from nucleus|poly-pyrimidine tract binding|nuclear speck|enzyme binding|pre-mRNA 3'-splice site binding|mRNA 3'-end processing|negative regulation of protein ubiquitination|positive regulation of RNA splicing|negative regulation of mRNA splicing, via spliceosome|C2H2 zinc finger domain binding|U2-type prespliceosome|U2AF|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion hsa03040 Spliceosome U2SURP 525.135361749319 554.393838773321 495.876884725316 0.89444876556081 -0.160929248483027 0.661337126453174 1 2.51425 2.11504 2.67717 1.62026 GeneID:23350,Genbank:NM_001320222.1,HGNC:HGNC:30855,MIM:617849 U2 snRNP associated SURP domain containing GO:0000398,GO:0003723,GO:0005634,GO:0005654 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm hsa03040 Spliceosome UACA 184.284850592792 173.702739353551 194.866961832033 1.12184161606919 0.16586900763939 0.684632333545025 1 0.746075 0.599096 1.01819 0.541618 GeneID:55075,Genbank:NM_018003.3,HGNC:HGNC:15947,MIM:612516 uveal autoantigen with coiled-coil domains and ankyrin repeats GO:0005576,GO:0005634,GO:0005829,GO:0005856,GO:0070062,GO:0097190,GO:1901222 extracellular region|nucleus|cytosol|cytoskeleton|extracellular exosome|apoptotic signaling pathway|regulation of NIK/NF-kappaB signaling UAP1 1837.78602587177 2046.10347568717 1629.46857605637 0.796376427398974 -0.328477576714323 0.0525176363818724 0.838606644358991 28.2305 24.7809 24.121 18.6371 GeneID:6675,Genbank:NM_001324115.1,HGNC:HGNC:12457,MIM:602862 UDP-N-acetylglucosamine pyrophosphorylase 1 GO:0003977,GO:0005654,GO:0005829,GO:0005886,GO:0006048,GO:0030246,GO:0042802 UDP-N-acetylglucosamine diphosphorylase activity|nucleoplasm|cytosol|plasma membrane|UDP-N-acetylglucosamine biosynthetic process|carbohydrate binding|identical protein binding hsa00520 Amino sugar and nucleotide sugar metabolism UAP1L1 592.022955227557 564.224692777792 619.821217677321 1.09853614280122 0.135582336472435 0.41245747928021 1 6.28591 5.4796 6.19074 6.3618 GeneID:91373,Genbank:XM_006717317.3,HGNC:HGNC:28082 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 GO:0003977,GO:0005829,GO:0006048 UDP-N-acetylglucosamine diphosphorylase activity|cytosol|UDP-N-acetylglucosamine biosynthetic process hsa00520 Amino sugar and nucleotide sugar metabolism UBA1 9052.70894394082 8712.35238317657 9393.06550470508 1.07813195467655 0.108533763161949 0.415124935774445 1 37.4097 38.5952 42.8646 41.0223 GeneID:7317,Genbank:NM_153280.2,HGNC:HGNC:12469,MIM:314370 ubiquitin like modifier activating enzyme 1 GO:0003723,GO:0004839,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006511,GO:0006974,GO:0016567,GO:0070062 RNA binding|ubiquitin activating enzyme activity|ATP binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|cytosol|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|protein ubiquitination|extracellular exosome hsa04120,hsa05012 Ubiquitin mediated proteolysis|Parkinson disease UBA2 3363.16069793386 3598.43011296627 3127.89128290145 0.869237746658098 -0.202177269960855 0.138234952101196 1 32.6134 33.3853 30.653 27.7203 GeneID:10054,Genbank:XM_005258404.3,HGNC:HGNC:30661,MIM:613295 ubiquitin like modifier activating enzyme 2 GO:0000287,GO:0005524,GO:0005654,GO:0005737,GO:0008047,GO:0008134,GO:0016925,GO:0019948,GO:0031510,GO:0032183,GO:0044388,GO:0044390,GO:0046982 magnesium ion binding|ATP binding|nucleoplasm|cytoplasm|enzyme activator activity|transcription factor binding|protein sumoylation|SUMO activating enzyme activity|SUMO activating enzyme complex|SUMO binding|small protein activating enzyme binding|ubiquitin-like protein conjugating enzyme binding|protein heterodimerization activity hsa04120 Ubiquitin mediated proteolysis UBA3 1621.38799893059 1692.92300136105 1549.85299650012 0.915489360859348 -0.127384974702702 0.392945089936173 1 29.422 26.7408 26.8603 24.8288 GeneID:9039,Genbank:NM_198195.1,HGNC:HGNC:12470,MIM:603172 ubiquitin like modifier activating enzyme 3 GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0007113,GO:0016881,GO:0016922,GO:0019781,GO:0019788,GO:0038061,GO:0042802,GO:0043687,GO:0045116,GO:0045892,GO:0046982,GO:0051726 ATP binding|nucleus|cytoplasm|cytosol|cellular protein modification process|proteolysis|endomitotic cell cycle|acid-amino acid ligase activity|ligand-dependent nuclear receptor binding|NEDD8 activating enzyme activity|NEDD8 transferase activity|NIK/NF-kappaB signaling|identical protein binding|post-translational protein modification|protein neddylation|negative regulation of transcription, DNA-templated|protein heterodimerization activity|regulation of cell cycle hsa04120 Ubiquitin mediated proteolysis UBA5 316.068568668317 352.488489170307 279.648648166326 0.793355405234843 -0.333960789482187 0.149099342607769 1 3.48686 2.61222 2.6027 2.20565 GeneID:79876,Genbank:NM_198329.3,HGNC:HGNC:23230,MIM:610552 ubiquitin like modifier activating enzyme 5 GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0033146,GO:0034976,GO:0043231,GO:0046872,GO:0071566,GO:0071569,GO:1990592 ATP binding|nucleus|cytoplasm|cytosol|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|intracellular membrane-bounded organelle|metal ion binding|UFM1 activating enzyme activity|protein ufmylation|protein K69-linked ufmylation UBA52 11791.2027532245 12368.4868214134 11213.9186850357 0.906652434283323 -0.141378496102192 0.382278084535691 1 70.5405 75.8382 66.2342 75.4921 GeneID:7311,Genbank:XM_005260054.2,HGNC:HGNC:12458,MIM:191321 ubiquitin A-52 residue ribosomal protein fusion product 1 GO:0003735,GO:0005654,GO:0005783,GO:0005829,GO:0005840,GO:0005886,GO:0006412 structural constituent of ribosome|nucleoplasm|endoplasmic reticulum|cytosol|ribosome|plasma membrane|translation hsa03010 Ribosome UBA6 574.973338970807 646.793768677489 503.152909264124 0.777918609656567 -0.362308874878065 0.383510665025447 1 4.43331 3.39024 3.94013 2.25784 GeneID:55236,Genbank:NM_018227.5,HGNC:HGNC:25581,MIM:611361 ubiquitin like modifier activating enzyme 6 GO:0004839,GO:0005524,GO:0005737,GO:0005829,GO:0006511,GO:0006974,GO:0007612,GO:0007626,GO:0016567,GO:0019780,GO:0021764,GO:0021766,GO:0042787,GO:0060996 ubiquitin activating enzyme activity|ATP binding|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|learning|locomotory behavior|protein ubiquitination|FAT10 activating enzyme activity|amygdala development|hippocampus development|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|dendritic spine development hsa04120 Ubiquitin mediated proteolysis UBA7 203.737502011969 177.69095415411 229.784049869828 1.29316684106799 0.370908419969082 0.503679141862495 1 1.55342 1.39595 2.47761 1.15764 GeneID:7318,Genbank:NM_003335.2,HGNC:HGNC:12471,MIM:191325 ubiquitin like modifier activating enzyme 7 GO:0004839,GO:0004842,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0006511,GO:0006974,GO:0019782,GO:0019985,GO:0032020,GO:0032480 ubiquitin activating enzyme activity|ubiquitin-protein transferase activity|ATP binding|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|ISG15 activating enzyme activity|translesion synthesis|ISG15-protein conjugation|negative regulation of type I interferon production hsa04120,hsa05012 Ubiquitin mediated proteolysis|Parkinson disease UBAC1 1219.65146774222 1098.85503034111 1340.44790514333 1.21985873307348 0.286714084759634 0.0556481979824063 0.856159019102997 20.0165 20.7057 25.0325 24.7311 GeneID:10422,Genbank:NM_016172.2,HGNC:HGNC:30221,MIM:608129 UBA domain containing 1 GO:0005794,GO:0005829,GO:0005886,GO:0016567,GO:0070062 Golgi apparatus|cytosol|plasma membrane|protein ubiquitination|extracellular exosome UBAC2 1345.3428769479 1330.36657781542 1360.31917608039 1.02251454506182 0.0321213653570643 0.845467629094026 1 7.57383 8.67832 8.46583 8.33078 GeneID:337867,Genbank:NM_001144072.1,HGNC:HGNC:20486 UBA domain containing 2 GO:0005783,GO:0005789,GO:0016021,GO:0043130,GO:0070972,GO:1904153 endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|ubiquitin binding|protein localization to endoplasmic reticulum|negative regulation of retrograde protein transport, ER to cytosol UBALD1 220.692354430193 237.372786987576 204.01192187281 0.859457920437562 -0.218501088647874 0.322720117422562 1 7.26674 6.99906 5.86032 6.50543 GeneID:124402,Genbank:NM_001330467.1,HGNC:HGNC:29576 UBA like domain containing 1 UBALD2 1131.73497730441 1113.52774643451 1149.94220817431 1.03270188987782 0.0464238514296624 0.766538121072269 1 37.379 36.0702 36.417 41.1796 GeneID:283991,Genbank:NM_182565.3,HGNC:HGNC:28438 UBA like domain containing 2 UBAP1 2582.58071786255 2518.65066668277 2646.51076904233 1.05076531813281 0.0714404883558413 0.600048913231187 1 25.9883 25.3876 27.5266 27.3671 GeneID:51271,Genbank:NM_001171204.2,HGNC:HGNC:12461,MIM:609787 ubiquitin associated protein 1 GO:0000813,GO:0005737,GO:0005794,GO:0005829,GO:0005886,GO:0010008,GO:0015031,GO:0016197,GO:0019058,GO:0043130,GO:0043162,GO:0043657,GO:0075733 ESCRT I complex|cytoplasm|Golgi apparatus|cytosol|plasma membrane|endosome membrane|protein transport|endosomal transport|viral life cycle|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|host cell|intracellular transport of virus UBAP1L 25.4010831448284 24.1477688648576 26.6543974247992 1.10380373333743 0.142483670202211 0.883041694184834 1 0.0115859 0.0131576 0.0191349 0.0178954 GeneID:390595,Genbank:XM_011521547.3,HGNC:HGNC:40028 ubiquitin associated protein 1 like GO:0000813,GO:0043130,GO:0043162 ESCRT I complex|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway UBAP2 1364.41004770967 1362.60441213927 1366.21568328008 1.00265027113419 0.00381847525703183 0.990329334119444 1 8.69041 8.85855 9.47657 8.36901 GeneID:55833,Genbank:NM_018449.3,HGNC:HGNC:14185 ubiquitin associated protein 2 GO:0003723,GO:0005634,GO:0005737,GO:0010628,GO:0045296 RNA binding|nucleus|cytoplasm|positive regulation of gene expression|cadherin binding UBAP2L 4844.98789987449 4908.60872775292 4781.36707199606 0.974077857329014 -0.0378910044140949 0.774703152358094 1 25.1205 25.4087 25.6923 24.4895 GeneID:9898,Genbank:NM_001127320.2,HGNC:HGNC:29877,MIM:616472 ubiquitin associated protein 2 like GO:0003723,GO:0005737,GO:0007339,GO:0010628,GO:0031519,GO:0061484 RNA binding|cytoplasm|binding of sperm to zona pellucida|positive regulation of gene expression|PcG protein complex|hematopoietic stem cell homeostasis UBASH3B 726.785554224417 680.004988152714 773.566120296119 1.13758889092501 0.185979281562885 0.373738876591826 1 2.69842 2.87863 3.66441 2.64893 GeneID:84959,Genbank:NM_032873.4,HGNC:HGNC:29884,MIM:609201 ubiquitin associated and SH3 domain containing B GO:0004725,GO:0005634,GO:0005737,GO:0006469,GO:0009968,GO:0031625,GO:0038063,GO:0042802,GO:0043393,GO:0045671,GO:0045779,GO:0051219,GO:0051279,GO:0070527,GO:0090331 protein tyrosine phosphatase activity|nucleus|cytoplasm|negative regulation of protein kinase activity|negative regulation of signal transduction|ubiquitin protein ligase binding|collagen-activated tyrosine kinase receptor signaling pathway|identical protein binding|regulation of protein binding|negative regulation of osteoclast differentiation|negative regulation of bone resorption|phosphoprotein binding|regulation of release of sequestered calcium ion into cytosol|platelet aggregation|negative regulation of platelet aggregation UBB 30144.6413013712 30601.0551515537 29688.2274511886 0.970170057998187 -0.0436904400341949 0.741152896516277 1 450.564 478.673 445.436 484.953 GeneID:7314,Genbank:NM_001281716.1,HGNC:HGNC:12463,MIM:191339 ubiquitin B GO:0005634,GO:0005739,GO:0007141,GO:0007144,GO:0008585,GO:0021888,GO:0043005,GO:0043025,GO:0043209,GO:0047497,GO:0048812,GO:0051881,GO:0060613,GO:0061136,GO:0072520,GO:0097009,GO:1901214,GO:1902255,GO:1902527 nucleus|mitochondrion|male meiosis I|female meiosis I|female gonad development|hypothalamus gonadotrophin-releasing hormone neuron development|neuron projection|neuronal cell body|myelin sheath|mitochondrion transport along microtubule|neuron projection morphogenesis|regulation of mitochondrial membrane potential|fat pad development|regulation of proteasomal protein catabolic process|seminiferous tubule development|energy homeostasis|regulation of neuron death|positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of protein monoubiquitination hsa04137,hsa04144,hsa05012,hsa05167 Mitophagy - animal|Endocytosis|Parkinson disease|Kaposi sarcoma-associated herpesvirus infection UBC 27365.1956185806 26065.7830398352 28664.6081973259 1.09970255462953 0.137113359213715 0.291555016540112 1 177.444 185.135 206.046 201.055 GeneID:7316,Genbank:NM_021009.6,HGNC:HGNC:12468,MIM:191340 ubiquitin C GO:0005654,GO:0005829,GO:0006914,GO:0007623,GO:0016567,GO:0031386,GO:0035096 nucleoplasm|cytosol|autophagy|circadian rhythm|protein ubiquitination|protein tag|larval midgut cell programmed cell death hsa03320 PPAR signaling pathway UBD 1.02816907859967 2.05633815719933 0 0 -Inf 0.409782672813165 1 0.0879175 0.0818601 0 0 GeneID:10537,Genbank:NM_006398.3,HGNC:HGNC:18795,MIM:606050 ubiquitin D UBE2A 3209.53274388532 3125.62622428959 3293.43926348106 1.0536894136245 0.0754496796358112 0.573554120138242 1 76.0401 76.6966 80.5517 81.6543 GeneID:7319,Genbank:NM_003336.3,HGNC:HGNC:12472,MIM:312180 ubiquitin conjugating enzyme E2 A GO:0000209,GO:0000785,GO:0000790,GO:0001701,GO:0001741,GO:0004842,GO:0005524,GO:0005737,GO:0006281,GO:0008284,GO:0009411,GO:0016567,GO:0016574,GO:0031625,GO:0033503,GO:0033522,GO:0043161,GO:0051865,GO:0060135,GO:0061630,GO:0061631,GO:0070936,GO:0070979 protein polyubiquitination|chromatin|nuclear chromatin|in utero embryonic development|XY body|ubiquitin-protein transferase activity|ATP binding|cytoplasm|DNA repair|positive regulation of cell proliferation|response to UV|protein ubiquitination|histone ubiquitination|ubiquitin protein ligase binding|HULC complex|histone H2A ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|protein autoubiquitination|maternal process involved in female pregnancy|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|protein K11-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2B 1028.08806278846 1141.2284426252 914.947682951714 0.80172176645636 -0.318826451472211 0.0395830877836323 0.756156754175857 23.4979 21.5233 17.8409 18.6579 GeneID:7320,Genbank:NM_003337.3,HGNC:HGNC:12473,MIM:179095 ubiquitin conjugating enzyme E2 B GO:0000209,GO:0000785,GO:0000790,GO:0001666,GO:0001701,GO:0001741,GO:0004842,GO:0005524,GO:0005634,GO:0005657,GO:0005737,GO:0005886,GO:0006281,GO:0006301,GO:0006344,GO:0006511,GO:0006513,GO:0006974,GO:0007283,GO:0007288,GO:0009411,GO:0010845,GO:0016567,GO:0031056,GO:0031625,GO:0032869,GO:0033128,GO:0033503,GO:0033522,GO:0042493,GO:0043066,GO:0043161,GO:0043951,GO:0045141,GO:0050821,GO:0051026,GO:0051865,GO:0060070,GO:0061630,GO:0061631,GO:0070076,GO:0070193,GO:0070534,GO:0070936,GO:0070979 protein polyubiquitination|chromatin|nuclear chromatin|response to hypoxia|in utero embryonic development|XY body|ubiquitin-protein transferase activity|ATP binding|nucleus|replication fork|cytoplasm|plasma membrane|DNA repair|postreplication repair|maintenance of chromatin silencing|ubiquitin-dependent protein catabolic process|protein monoubiquitination|cellular response to DNA damage stimulus|spermatogenesis|sperm axoneme assembly|response to UV|positive regulation of reciprocal meiotic recombination|protein ubiquitination|regulation of histone modification|ubiquitin protein ligase binding|cellular response to insulin stimulus|negative regulation of histone phosphorylation|HULC complex|histone H2A ubiquitination|response to drug|negative regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of cAMP-mediated signaling|meiotic telomere clustering|protein stabilization|chiasma assembly|protein autoubiquitination|canonical Wnt signaling pathway|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|histone lysine demethylation|synaptonemal complex organization|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2C 3008.11878729353 3251.12170380939 2765.11587077766 0.850511338144533 -0.233597626340431 0.0863997724149828 0.964561165794104 50.8689 50.5003 42.2894 46.2474 GeneID:11065,Genbank:NM_181799.2,HGNC:HGNC:15937,MIM:605574 ubiquitin conjugating enzyme E2 C hsa04120 Ubiquitin mediated proteolysis UBE2D1 252.536368001629 257.88712528403 247.185610719229 0.958503106531532 -0.061144987177168 0.893665489357273 1 5.85975 4.28722 5.55152 4.26377 GeneID:7321,Genbank:NM_003338.4,HGNC:HGNC:12474,MIM:602961 ubiquitin conjugating enzyme E2 D1 GO:0000122,GO:0000151,GO:0000209,GO:0002223,GO:0002756,GO:0004842,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0016567,GO:0016579,GO:0030509,GO:0031145,GO:0031398,GO:0035666,GO:0038095,GO:0042787,GO:0043161,GO:0043234,GO:0050852,GO:0051436,GO:0051437,GO:0051439,GO:0061418,GO:0061631,GO:0070936,GO:1902916 negative regulation of transcription from RNA polymerase II promoter|ubiquitin ligase complex|protein polyubiquitination|stimulatory C-type lectin receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|ubiquitin-protein transferase activity|ATP binding|nucleoplasm|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|protein deubiquitination|BMP signaling pathway|anaphase-promoting complex-dependent catabolic process|positive regulation of protein ubiquitination|TRIF-dependent toll-like receptor signaling pathway|Fc-epsilon receptor signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein complex|T cell receptor signaling pathway|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of transcription from RNA polymerase II promoter in response to hypoxia|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|positive regulation of protein polyubiquitination hsa04120,hsa04141 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum UBE2D2 3255.04709426793 3345.02229088561 3165.07189765025 0.946203529427685 -0.0797775526402755 0.551519799434273 1 44.2266 46.3201 43.1998 42.0446 GeneID:7322,Genbank:NM_181838.1,HGNC:HGNC:12475,MIM:602962 ubiquitin conjugating enzyme E2 D2 GO:0000151,GO:0000209,GO:0004842,GO:0005524,GO:0016567,GO:0043234,GO:0051865,GO:0061631,GO:0070062,GO:0070936 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|ATP binding|protein ubiquitination|protein complex|protein autoubiquitination|ubiquitin conjugating enzyme activity|extracellular exosome|protein K48-linked ubiquitination hsa04120,hsa04141,hsa05131 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Shigellosis UBE2D3 3932.66835281186 4128.83210435561 3736.50460126811 0.904978576708504 -0.144044454782379 0.285332328978154 1 27.1184 26.34 25.4439 23.7063 GeneID:7323,Genbank:NM_181893.2,HGNC:HGNC:12476,MIM:602963 ubiquitin conjugating enzyme E2 D3 GO:0000209,GO:0004842,GO:0005524,GO:0005886,GO:0006281,GO:0006513,GO:0006915,GO:0010008,GO:0016567,GO:0043161,GO:0051865,GO:0061631,GO:0070936,GO:0070979,GO:1903955 protein polyubiquitination|ubiquitin-protein transferase activity|ATP binding|plasma membrane|DNA repair|protein monoubiquitination|apoptotic process|endosome membrane|protein ubiquitination|proteasome-mediated ubiquitin-dependent protein catabolic process|protein autoubiquitination|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|protein K11-linked ubiquitination|positive regulation of protein targeting to mitochondrion hsa04120,hsa04141 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum UBE2D4 526.363615271855 520.148709567808 532.578520975902 1.02389664951476 0.0340700993638861 0.861587978321575 1 3.8707 4.48518 4.35142 4.46088 GeneID:51619,Genbank:XM_011515422.3,HGNC:HGNC:21647 ubiquitin conjugating enzyme E2 D4 (putative) GO:0004842,GO:0005524,GO:0016567,GO:0035519,GO:0044314,GO:0061631,GO:0070534,GO:0070936,GO:0070979,GO:0085020 ubiquitin-protein transferase activity|ATP binding|protein ubiquitination|protein K29-linked ubiquitination|protein K27-linked ubiquitination|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination hsa04120,hsa04141 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum UBE2E1 2334.11831529392 2336.6931487351 2331.54348185275 0.997796173243738 -0.00318295856654844 0.991532730087775 1 20.7511 19.6666 21.3273 20.3417 GeneID:7324,Genbank:NM_003341.4,HGNC:HGNC:12477,MIM:602916 ubiquitin conjugating enzyme E2 E1 GO:0000151,GO:0000209,GO:0004842,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0006511,GO:0010390,GO:0016567,GO:0031145,GO:0032020,GO:0033523,GO:0042296,GO:0042787,GO:0043161,GO:0051436,GO:0051437,GO:0051439,GO:0061631,GO:0070936 ubiquitin ligase complex|protein polyubiquitination|ubiquitin-protein transferase activity|ATP binding|nucleus|nucleoplasm|cytosol|ubiquitin-dependent protein catabolic process|histone monoubiquitination|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|ISG15-protein conjugation|histone H2B ubiquitination|ISG15 transferase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2E2 919.151399567331 1000.94864515583 837.354153978835 0.83656055486091 -0.257458120630213 0.16581027460851 1 1.116 1.38027 0.939253 1.13651 GeneID:7325,Genbank:XM_011534076.3,HGNC:HGNC:12478,MIM:602163 ubiquitin conjugating enzyme E2 E2 GO:0004842,GO:0005524,GO:0006974,GO:0032020,GO:0042296,GO:0061631,GO:0070534,GO:0070936,GO:0070979,GO:1900087 ubiquitin-protein transferase activity|ATP binding|cellular response to DNA damage stimulus|ISG15-protein conjugation|ISG15 transferase activity|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|positive regulation of G1/S transition of mitotic cell cycle hsa04120 Ubiquitin mediated proteolysis UBE2E3 1591.75769150893 1649.70269944115 1533.81268357672 0.929750969126928 -0.10508374825458 0.4738873044623 1 8.77416 8.85658 8.22469 8.43855 GeneID:10477,Genbank:NM_182678.2,HGNC:HGNC:12479,MIM:604151 ubiquitin conjugating enzyme E2 E3 GO:0004842,GO:0005524,GO:0005654,GO:0005829,GO:0016567,GO:0040008,GO:0061631,GO:0070534,GO:0070936,GO:0070979 ubiquitin-protein transferase activity|ATP binding|nucleoplasm|cytosol|protein ubiquitination|regulation of growth|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2F 635.116593855721 683.329626761938 586.903560949505 0.858887918749605 -0.219458216857948 0.183174471511418 1 10.2451 10.4061 9.18587 8.41869 GeneID:140739,Genbank:NM_080678.2,HGNC:HGNC:12480,MIM:617700 ubiquitin conjugating enzyme E2 F (putative) GO:0005524,GO:0005737,GO:0005829,GO:0019788,GO:0031625,GO:0043687,GO:0045116,GO:0061630 ATP binding|cytoplasm|cytosol|NEDD8 transferase activity|ubiquitin protein ligase binding|post-translational protein modification|protein neddylation|ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE2G1 1431.46141141987 1495.27542389735 1367.6473989424 0.914645808447587 -0.12871491905629 0.384562004994618 1 17.3472 16.955 16.4784 14.8718 GeneID:7326,Genbank:NM_003342.4,HGNC:HGNC:12482,MIM:601569 ubiquitin conjugating enzyme E2 G1 GO:0000209,GO:0004842,GO:0005524,GO:0005737,GO:0006511,GO:0016567,GO:0031625,GO:0044257,GO:0061630,GO:0061631,GO:0070062,GO:0070534,GO:0070936 protein polyubiquitination|ubiquitin-protein transferase activity|ATP binding|cytoplasm|ubiquitin-dependent protein catabolic process|protein ubiquitination|ubiquitin protein ligase binding|cellular protein catabolic process|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|extracellular exosome|protein K63-linked ubiquitination|protein K48-linked ubiquitination hsa04120,hsa04141,hsa05012 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease UBE2G2 2329.45387148739 2307.5408386479 2351.36690432687 1.01899254173315 0.0271434920886366 0.852805102051287 1 24.9561 26.3229 26.8674 26.1275 GeneID:7327,Genbank:NM_001202489.1,HGNC:HGNC:12483,MIM:603124 ubiquitin conjugating enzyme E2 G2 GO:0004842,GO:0005524,GO:0005783,GO:0005829,GO:0006511,GO:0016567,GO:0018279,GO:0030433,GO:0031625,GO:0035458,GO:0042802,GO:0044257,GO:0061630,GO:0061631,GO:0070936,GO:1904153 ubiquitin-protein transferase activity|ATP binding|endoplasmic reticulum|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|protein N-linked glycosylation via asparagine|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|cellular response to interferon-beta|identical protein binding|cellular protein catabolic process|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|negative regulation of retrograde protein transport, ER to cytosol hsa04120,hsa04141,hsa05012 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease UBE2H 11249.1553338298 11817.9424979148 10680.3681697448 0.903741761446994 -0.146017504440471 0.257548878092616 1 100.685 105.994 97.6692 90.4552 GeneID:7328,Genbank:NM_182697.2,HGNC:HGNC:12484,MIM:601082 ubiquitin conjugating enzyme E2 H GO:0004842,GO:0005524,GO:0005737,GO:0005829,GO:0006511,GO:0016567,GO:0031625,GO:0043161,GO:0061630,GO:0061631,GO:0070936,GO:0070979 ubiquitin-protein transferase activity|ATP binding|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|protein ubiquitination|ubiquitin protein ligase binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination|protein K11-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2I 2776.5497871982 2968.75062573771 2584.34894865869 0.870517357117691 -0.200055031039738 0.141718112314598 1 25.7721 27.2661 22.2627 24.8273 GeneID:7329,Genbank:NM_194260.2,HGNC:HGNC:12485,MIM:601661 ubiquitin conjugating enzyme E2 I GO:0000122,GO:0001650,GO:0003723,GO:0004842,GO:0005524,GO:0005634,GO:0005635,GO:0005737,GO:0006511,GO:0007049,GO:0007059,GO:0008022,GO:0008134,GO:0010469,GO:0016604,GO:0016605,GO:0016925,GO:0019789,GO:0019899,GO:0030425,GO:0033145,GO:0043123,GO:0043161,GO:0043398,GO:0043425,GO:0044388,GO:0045202,GO:0045892,GO:0051091,GO:0051301,GO:0061656,GO:0071535,GO:1903755,GO:1990234,GO:1990356 negative regulation of transcription from RNA polymerase II promoter|fibrillar center|RNA binding|ubiquitin-protein transferase activity|ATP binding|nucleus|nuclear envelope|cytoplasm|ubiquitin-dependent protein catabolic process|cell cycle|chromosome segregation|protein C-terminus binding|transcription factor binding|regulation of receptor activity|nuclear body|PML body|protein sumoylation|SUMO transferase activity|enzyme binding|dendrite|positive regulation of intracellular steroid hormone receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|proteasome-mediated ubiquitin-dependent protein catabolic process|HLH domain binding|bHLH transcription factor binding|small protein activating enzyme binding|synapse|negative regulation of transcription, DNA-templated|positive regulation of DNA binding transcription factor activity|cell division|SUMO conjugating enzyme activity|RING-like zinc finger domain binding|positive regulation of SUMO transferase activity|transferase complex|sumoylated E2 ligase complex hsa03013,hsa04064,hsa04120,hsa05206 RNA transport|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|MicroRNAs in cancer UBE2J1 2034.77544070634 2335.13567363411 1734.41520777856 0.742747082048271 -0.429057062578619 0.00241017734292607 0.178923131662484 19.4774 18.9715 14.1426 14.6567 GeneID:51465,Genbank:XM_011535887.2,HGNC:HGNC:17598,MIM:616175 ubiquitin conjugating enzyme E2 J1 GO:0005524,GO:0005737,GO:0005789,GO:0007286,GO:0016021,GO:0018279,GO:0030433,GO:0031625,GO:0042534,GO:0061630,GO:0061631,GO:1904153 ATP binding|cytoplasm|endoplasmic reticulum membrane|spermatid development|integral component of membrane|protein N-linked glycosylation via asparagine|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|regulation of tumor necrosis factor biosynthetic process|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|negative regulation of retrograde protein transport, ER to cytosol hsa04120,hsa04141,hsa05012 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease UBE2J2 1768.67749955322 1822.79192287976 1714.56307622668 0.940624683873904 -0.0883089029899884 0.532917938846943 1 15.5399 14.8025 14.3207 14.7684 GeneID:118424,Genbank:NM_194457.1,HGNC:HGNC:19268 ubiquitin conjugating enzyme E2 J2 GO:0000151,GO:0000209,GO:0005524,GO:0005783,GO:0005789,GO:0006986,GO:0016021,GO:0016567,GO:0030433,GO:0031625,GO:0061630,GO:0061631,GO:1903955 ubiquitin ligase complex|protein polyubiquitination|ATP binding|endoplasmic reticulum|endoplasmic reticulum membrane|response to unfolded protein|integral component of membrane|protein ubiquitination|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|positive regulation of protein targeting to mitochondrion hsa04120,hsa04141,hsa05012 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum|Parkinson disease UBE2K 1947.28073564311 2010.77132547241 1883.79014581381 0.936849517371765 -0.094110763093172 0.525718547220672 1 18.9259 17.6392 17.9485 16.2565 GeneID:3093,Genbank:NM_005339.4,HGNC:HGNC:4914,MIM:602846 ubiquitin conjugating enzyme E2 K GO:0000209,GO:0004842,GO:0005524,GO:0005634,GO:0005737,GO:0010800,GO:0010994,GO:0031625,GO:0032433,GO:0032434,GO:0034450,GO:0035458,GO:0043161,GO:0060340,GO:0061630,GO:0061631,GO:0070936 protein polyubiquitination|ubiquitin-protein transferase activity|ATP binding|nucleus|cytoplasm|positive regulation of peptidyl-threonine phosphorylation|free ubiquitin chain polymerization|ubiquitin protein ligase binding|filopodium tip|regulation of proteasomal ubiquitin-dependent protein catabolic process|ubiquitin-ubiquitin ligase activity|cellular response to interferon-beta|proteasome-mediated ubiquitin-dependent protein catabolic process|positive regulation of type I interferon-mediated signaling pathway|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K48-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2L3 3272.75862300252 3357.17598938347 3188.34125662158 0.949709299334976 -0.0744421146943998 0.587994740507558 1 32.3429 32.8248 32.2652 31.3807 GeneID:7332,Genbank:NM_001256355.1,HGNC:HGNC:12488,MIM:603721 ubiquitin conjugating enzyme E2 L3 GO:0000151,GO:0000209,GO:0003713,GO:0003723,GO:0004842,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0006464,GO:0006511,GO:0008283,GO:0016567,GO:0019899,GO:0031398,GO:0031625,GO:0042787,GO:0044770,GO:0051443,GO:0061631,GO:0070062,GO:0070979,GO:0071383,GO:0071385,GO:0097027,GO:1903955 ubiquitin ligase complex|protein polyubiquitination|transcription coactivator activity|RNA binding|ubiquitin-protein transferase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular protein modification process|ubiquitin-dependent protein catabolic process|cell proliferation|protein ubiquitination|enzyme binding|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|cell cycle phase transition|positive regulation of ubiquitin-protein transferase activity|ubiquitin conjugating enzyme activity|extracellular exosome|protein K11-linked ubiquitination|cellular response to steroid hormone stimulus|cellular response to glucocorticoid stimulus|ubiquitin-protein transferase activator activity|positive regulation of protein targeting to mitochondrion hsa04120,hsa05012 Ubiquitin mediated proteolysis|Parkinson disease UBE2L5 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.026816 0 GeneID:171222,Genbank:NM_001355247.1,HGNC:HGNC:13477 ubiquitin conjugating enzyme E2 L5 GO:0000151,GO:0000209,GO:0003713,GO:0003723,GO:0004842,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0006464,GO:0006511,GO:0008283,GO:0016567,GO:0019899,GO:0031398,GO:0031625,GO:0042787,GO:0044770,GO:0051443,GO:0061631,GO:0070062,GO:0070979,GO:0071383,GO:0071385,GO:0097027,GO:1903955 ubiquitin ligase complex|protein polyubiquitination|transcription coactivator activity|RNA binding|ubiquitin-protein transferase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular protein modification process|ubiquitin-dependent protein catabolic process|cell proliferation|protein ubiquitination|enzyme binding|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|cell cycle phase transition|positive regulation of ubiquitin-protein transferase activity|ubiquitin conjugating enzyme activity|extracellular exosome|protein K11-linked ubiquitination|cellular response to steroid hormone stimulus|cellular response to glucocorticoid stimulus|ubiquitin-protein transferase activator activity|positive regulation of protein targeting to mitochondrion UBE2L6 537.642327859549 407.674452492749 667.610203226349 1.63760618097163 0.711588452784344 0.394845680038442 1 9.44813 9.77849 24.1172 8.75288 GeneID:9246,Genbank:NM_198183.2,HGNC:HGNC:12490,MIM:603890 ubiquitin conjugating enzyme E2 L6 GO:0004842,GO:0005654,GO:0005829,GO:0006464,GO:0019941,GO:0019985,GO:0032020,GO:0032480,GO:0042296,GO:0043130,GO:0044267 ubiquitin-protein transferase activity|nucleoplasm|cytosol|cellular protein modification process|modification-dependent protein catabolic process|translesion synthesis|ISG15-protein conjugation|negative regulation of type I interferon production|ISG15 transferase activity|ubiquitin binding|cellular protein metabolic process hsa04120,hsa05012 Ubiquitin mediated proteolysis|Parkinson disease UBE2M 4316.3031559795 4434.00250895099 4198.60380300801 0.946910560950795 -0.0786999304042433 0.535443995347188 1 137.526 147.901 135.317 142.682 GeneID:9040,Genbank:NM_003969.3,HGNC:HGNC:12491,MIM:603173 ubiquitin conjugating enzyme E2 M GO:0004842,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0007179,GO:0016874,GO:0019788,GO:0038061,GO:0043525,GO:0043687,GO:0045116,GO:0070062 ubiquitin-protein transferase activity|ATP binding|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|transforming growth factor beta receptor signaling pathway|ligase activity|NEDD8 transferase activity|NIK/NF-kappaB signaling|positive regulation of neuron apoptotic process|post-translational protein modification|protein neddylation|extracellular exosome hsa04120 Ubiquitin mediated proteolysis UBE2N 1955.10339586197 2114.27142683392 1795.93536489001 0.849434628920554 -0.235425170622107 0.098797683791799 1 42.415 39.8671 33.6853 36.7225 GeneID:7334,Genbank:NM_003348.3,HGNC:HGNC:12492,MIM:603679 ubiquitin conjugating enzyme E2 N GO:0000151,GO:0000187,GO:0000724,GO:0000729,GO:0001650,GO:0002223,GO:0003723,GO:0004842,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006282,GO:0006301,GO:0006303,GO:0006464,GO:0006508,GO:0007254,GO:0016567,GO:0016574,GO:0031058,GO:0031372,GO:0031625,GO:0033182,GO:0035370,GO:0038095,GO:0043123,GO:0043130,GO:0043234,GO:0045739,GO:0050852,GO:0051092,GO:0051443,GO:0061630,GO:0070062,GO:0070423,GO:0070498,GO:0070534,GO:0070911 ubiquitin ligase complex|activation of MAPK activity|double-strand break repair via homologous recombination|DNA double-strand break processing|fibrillar center|stimulatory C-type lectin receptor signaling pathway|RNA binding|ubiquitin-protein transferase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|regulation of DNA repair|postreplication repair|double-strand break repair via nonhomologous end joining|cellular protein modification process|proteolysis|JNK cascade|protein ubiquitination|histone ubiquitination|positive regulation of histone modification|UBC13-MMS2 complex|ubiquitin protein ligase binding|regulation of histone ubiquitination|UBC13-UEV1A complex|Fc-epsilon receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin binding|protein complex|positive regulation of DNA repair|T cell receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein transferase activity|ubiquitin protein ligase activity|extracellular exosome|nucleotide-binding oligomerization domain containing signaling pathway|interleukin-1-mediated signaling pathway|protein K63-linked ubiquitination|global genome nucleotide-excision repair hsa04120 Ubiquitin mediated proteolysis UBE2O 1248.61348640265 1198.9530408534 1298.2739319519 1.08283968405285 0.114819665714229 0.453129276094116 1 6.82753 7.25218 7.74023 7.84349 GeneID:63893,Genbank:XM_024450866.1,HGNC:HGNC:29554,MIM:617649 ubiquitin conjugating enzyme E2 O GO:0003723,GO:0004842,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006513,GO:0016604,GO:0030513,GO:0031625,GO:0042147,GO:0061630,GO:0061631,GO:0070534 RNA binding|ubiquitin-protein transferase activity|ATP binding|nucleus|cytoplasm|cytosol|protein monoubiquitination|nuclear body|positive regulation of BMP signaling pathway|ubiquitin protein ligase binding|retrograde transport, endosome to Golgi|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2Q1 2395.07716866788 2491.09303231529 2299.06130502047 0.922912663315375 -0.115733965069842 0.400517733228202 1 27.9862 28.4776 26.6802 25.4395 GeneID:55585,Genbank:NM_017582.6,HGNC:HGNC:15698,MIM:617429 ubiquitin conjugating enzyme E2 Q1 GO:0001967,GO:0005524,GO:0005634,GO:0005829,GO:0007566,GO:0007617,GO:0009566,GO:0030175,GO:0061458,GO:0061631,GO:0070459 suckling behavior|ATP binding|nucleus|cytosol|embryo implantation|mating behavior|fertilization|filopodium|reproductive system development|ubiquitin conjugating enzyme activity|prolactin secretion hsa04120 Ubiquitin mediated proteolysis UBE2Q2 592.695027569983 623.636968272509 561.753086867458 0.900769382584115 -0.15077030426402 0.502449401854378 1 3.02174 2.91392 3.10765 2.39778 GeneID:92912,Genbank:NM_173469.3,HGNC:HGNC:19248,MIM:612501 ubiquitin conjugating enzyme E2 Q2 GO:0004842,GO:0005524,GO:0005829,GO:0016567,GO:0070936 ubiquitin-protein transferase activity|ATP binding|cytosol|protein ubiquitination|protein K48-linked ubiquitination hsa04120 Ubiquitin mediated proteolysis UBE2Q2L 10.1973249514455 8.76345030543964 11.6311995974513 1.32723975056167 0.408429000477698 0.685881029128707 1 0.0875738 0.0265405 0.0824808 0.0386206 GeneID:100505679,Genbank:XM_017021854.1,HGNC:HGNC:44656 ubiquitin conjugating enzyme E2 Q2 like UBE2R2 2019.66364241981 2116.37884226837 1922.94844257125 0.908603131049165 -0.138277817952623 0.316447013523799 1 18.8648 20.8969 18.0005 18.5455 GeneID:54926,Genbank:XM_011517949.1,HGNC:HGNC:19907,MIM:612506 ubiquitin conjugating enzyme E2 R2 GO:0004842,GO:0005524,GO:0006513,GO:0070936 ubiquitin-protein transferase activity|ATP binding|protein monoubiquitination|protein K48-linked ubiquitination hsa04120,hsa05168 Ubiquitin mediated proteolysis|Herpes simplex infection UBE2S 12832.2406739513 13149.8807888432 12514.6005590594 0.951689278406024 -0.071437476894832 0.662688356349097 1 240.009 268.051 230.367 263.819 GeneID:27338,Genbank:NM_014501.2,HGNC:HGNC:17895,MIM:610309 ubiquitin conjugating enzyme E2 S GO:0004842,GO:0005524,GO:0005654,GO:0005680,GO:0005737,GO:0005829,GO:0006464,GO:0010458,GO:0010994,GO:0016567,GO:0031145,GO:0031625,GO:0035519,GO:0044314,GO:0051301,GO:0061630,GO:0061631,GO:0070534,GO:0070979,GO:0085020,GO:1904668 ubiquitin-protein transferase activity|ATP binding|nucleoplasm|anaphase-promoting complex|cytoplasm|cytosol|cellular protein modification process|exit from mitosis|free ubiquitin chain polymerization|protein ubiquitination|anaphase-promoting complex-dependent catabolic process|ubiquitin protein ligase binding|protein K29-linked ubiquitination|protein K27-linked ubiquitination|cell division|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination|positive regulation of ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE2T 1390.88266574152 1468.99589863699 1312.76943284604 0.8936508495797 -0.162216816016352 0.263764879620742 1 44.5666 47.8805 39.194 42.8728 GeneID:29089,Genbank:NM_014176.3,HGNC:HGNC:25009,MIM:610538 ubiquitin conjugating enzyme E2 T GO:0003682,GO:0004842,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006281,GO:0006513,GO:0006974,GO:0016567,GO:0031625,GO:0035519,GO:0036297,GO:0044314,GO:0051865,GO:0061630,GO:0061631,GO:0070534,GO:0070936,GO:0070979,GO:0085020 chromatin binding|ubiquitin-protein transferase activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|DNA repair|protein monoubiquitination|cellular response to DNA damage stimulus|protein ubiquitination|ubiquitin protein ligase binding|protein K29-linked ubiquitination|interstrand cross-link repair|protein K27-linked ubiquitination|protein autoubiquitination|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination|protein K6-linked ubiquitination hsa03460 Fanconi anemia pathway UBE2V1 25.9844776987352 25.3102081124042 26.6587472850662 1.05328044584513 0.0748896186630028 0.915259837742326 1 0.630908 0.54576 0.763898 0.543163 GeneID:7335,Genbank:NM_022442.5,HGNC:HGNC:12494,MIM:602995 ubiquitin conjugating enzyme E2 V1 GO:0000151,GO:0005634,GO:0005737,GO:0006301,GO:0031625,GO:0035370,GO:0061630,GO:0070534 ubiquitin ligase complex|nucleus|cytoplasm|postreplication repair|ubiquitin protein ligase binding|UBC13-UEV1A complex|ubiquitin protein ligase activity|protein K63-linked ubiquitination UBE2V2 883.095104329901 936.987388871128 829.202819788673 0.884966894578685 -0.176304607963461 0.382554638549767 1 12.9132 10.75 10.9177 10.1998 GeneID:7336,Genbank:XM_017013808.2,HGNC:HGNC:12495,MIM:603001 ubiquitin conjugating enzyme E2 V2 GO:0000209,GO:0000729,GO:0005634,GO:0005654,GO:0005737,GO:0006282,GO:0006301,GO:0006303,GO:0008283,GO:0010976,GO:0016567,GO:0031372,GO:0031625,GO:0032436,GO:0042275,GO:0043524,GO:0045739,GO:0051965,GO:0061630,GO:0061631,GO:0070062,GO:0070534,GO:0070911 protein polyubiquitination|DNA double-strand break processing|nucleus|nucleoplasm|cytoplasm|regulation of DNA repair|postreplication repair|double-strand break repair via nonhomologous end joining|cell proliferation|positive regulation of neuron projection development|protein ubiquitination|UBC13-MMS2 complex|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|error-free postreplication DNA repair|negative regulation of neuron apoptotic process|positive regulation of DNA repair|positive regulation of synapse assembly|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity|extracellular exosome|protein K63-linked ubiquitination|global genome nucleotide-excision repair UBE2W 386.647900428061 401.072184548132 372.223616307991 0.928071381283537 -0.107692322440403 0.586593232382816 1 2.19927 1.99702 2.23903 1.70254 GeneID:55284,Genbank:NM_001271015.1,HGNC:HGNC:25616,MIM:614277 ubiquitin conjugating enzyme E2 W GO:0004842,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006513,GO:0006515,GO:0016567,GO:0031625,GO:0043161,GO:0061630,GO:0070979,GO:0071218 ubiquitin-protein transferase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|DNA repair|protein monoubiquitination|protein quality control for misfolded or incompletely synthesized proteins|protein ubiquitination|ubiquitin protein ligase binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin protein ligase activity|protein K11-linked ubiquitination|cellular response to misfolded protein hsa04120 Ubiquitin mediated proteolysis UBE2Z 4502.86398248908 4336.83410119448 4668.89386378368 1.07656731957945 0.106438536492391 0.438657052070789 1 55.125 60.5232 64.6178 62.1519 GeneID:65264,Genbank:NM_023079.4,HGNC:HGNC:25847,MIM:611362 ubiquitin conjugating enzyme E2 Z GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006915,GO:0016567,GO:0031625,GO:0042787,GO:0043065,GO:0061630,GO:0061631 ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|apoptotic process|protein ubiquitination|ubiquitin protein ligase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of apoptotic process|ubiquitin protein ligase activity|ubiquitin conjugating enzyme activity hsa04120 Ubiquitin mediated proteolysis UBE3A 1461.66548601466 1354.9053145303 1568.42565749903 1.15759060111352 0.21112511327982 0.262329138850121 1 5.92974 5.46127 7.7349 5.8034 GeneID:7337,Genbank:NM_001354546.1,HGNC:HGNC:12496,MIM:601623 ubiquitin protein ligase E3A hsa04120,hsa05165,hsa05203 Ubiquitin mediated proteolysis|Human papillomavirus infection|Viral carcinogenesis UBE3B 1006.14164447223 974.715112168446 1037.56817677602 1.06448352326019 0.0901536190294914 0.56247285857582 1 5.15748 5.43562 5.74075 5.64569 GeneID:89910,Genbank:XM_011538961.1,HGNC:HGNC:13478,MIM:608047 ubiquitin protein ligase E3B GO:0005737,GO:0061630 cytoplasm|ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE3C 5093.83672879328 5360.61687813758 4827.05657944897 0.900466623372274 -0.15125529259001 0.258610870424582 1 44.1973 43.0175 41.8786 37.655 GeneID:9690,Genbank:XM_017012818.1,HGNC:HGNC:16803,MIM:614454 ubiquitin protein ligase E3C GO:0000209,GO:0000502,GO:0004842,GO:0005622,GO:0005634,GO:0005737,GO:0061630 protein polyubiquitination|proteasome complex|ubiquitin-protein transferase activity|intracellular|nucleus|cytoplasm|ubiquitin protein ligase activity hsa04120 Ubiquitin mediated proteolysis UBE3D 161.393742610613 174.980848460683 147.806636760543 0.844701794858164 -0.243485978357035 0.336306987082755 1 0.676804 0.622295 0.541062 0.546636 GeneID:90025,Genbank:XM_017011458.2,HGNC:HGNC:21381,MIM:612495 ubiquitin protein ligase E3D GO:0000151,GO:0000209,GO:0005737,GO:0006513,GO:0030332,GO:0044390,GO:0051865,GO:0061630 ubiquitin ligase complex|protein polyubiquitination|cytoplasm|protein monoubiquitination|cyclin binding|ubiquitin-like protein conjugating enzyme binding|protein autoubiquitination|ubiquitin protein ligase activity UBE4A 867.590798630887 952.468776980771 782.712820281004 0.821772680845375 -0.283188724790677 0.0736204003711633 0.934750619674839 6.14017 5.73498 5.20089 4.47068 GeneID:9354,Genbank:NM_004788.3,HGNC:HGNC:12499,MIM:603753 ubiquitination factor E4A GO:0000151,GO:0000209,GO:0005634,GO:0005737,GO:0006511,GO:0030433,GO:0034450 ubiquitin ligase complex|protein polyubiquitination|nucleus|cytoplasm|ubiquitin-dependent protein catabolic process|ubiquitin-dependent ERAD pathway|ubiquitin-ubiquitin ligase activity hsa04120 Ubiquitin mediated proteolysis UBE4B 1416.11588648458 1420.90125766027 1411.3305153089 0.993264315658971 -0.0097504132375985 0.960510854032973 1 7.70493 7.27014 7.93323 6.86137 GeneID:10277,Genbank:XM_005263422.2,HGNC:HGNC:12500,MIM:613565 ubiquitination factor E4B GO:0000151,GO:0000209,GO:0003222,GO:0005524,GO:0005634,GO:0005737,GO:0006513,GO:0008626,GO:0009411,GO:0019899,GO:0030433,GO:0031175,GO:0034450,GO:0042787,GO:0043161,GO:0051117,GO:0051865 ubiquitin ligase complex|protein polyubiquitination|ventricular trabecula myocardium morphogenesis|ATP binding|nucleus|cytoplasm|protein monoubiquitination|granzyme-mediated apoptotic signaling pathway|response to UV|enzyme binding|ubiquitin-dependent ERAD pathway|neuron projection development|ubiquitin-ubiquitin ligase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ATPase binding|protein autoubiquitination hsa04120,hsa04141 Ubiquitin mediated proteolysis|Protein processing in endoplasmic reticulum UBFD1 2397.14543172748 2470.8178083914 2323.47305506355 0.940365998323535 -0.0887057198020563 0.518871604498277 1 16.0682 16.506 17.1487 13.8978 GeneID:56061,Genbank:NM_019116.2,HGNC:HGNC:30565 ubiquitin family domain containing 1 GO:0045296 cadherin binding UBIAD1 910.394414895547 972.236346194191 848.552483596902 0.872784160886962 -0.196303174730401 0.199061986546627 1 4.35534 4.77508 3.90508 4.07284 GeneID:29914,Genbank:NM_001330349.1,HGNC:HGNC:30791,MIM:611632 UbiA prenyltransferase domain containing 1 GO:0004659,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0006744,GO:0009234,GO:0016020,GO:0016209,GO:0030173,GO:0031966,GO:0032194,GO:0042371,GO:0042373 prenyltransferase activity|nucleus|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|ubiquinone biosynthetic process|menaquinone biosynthetic process|membrane|antioxidant activity|integral component of Golgi membrane|mitochondrial membrane|ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate|vitamin K biosynthetic process|vitamin K metabolic process UBL3 644.901976963123 657.796870584615 632.007083341631 0.960793691189101 -0.0577014169080122 0.798754620775264 1 8.54472 7.23272 8.39906 6.67553 GeneID:5412,Genbank:NM_007106.3,HGNC:HGNC:12504,MIM:604711 ubiquitin like 3 GO:0005622,GO:0005886,GO:0070062 intracellular|plasma membrane|extracellular exosome UBL4A 2714.69035070344 2698.6881506439 2730.69255076299 1.01185924357783 0.0170086154119773 0.913549388062876 1 46.7267 48.2982 45.6247 51.0828 GeneID:8266,Genbank:NM_014235.4,HGNC:HGNC:12505,MIM:312070 ubiquitin like 4A GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006464,GO:0016020,GO:0019787,GO:0051087,GO:0071816,GO:0071818 nucleus|nucleoplasm|cytoplasm|cytosol|cellular protein modification process|membrane|ubiquitin-like protein transferase activity|chaperone binding|tail-anchored membrane protein insertion into ER membrane|BAT3 complex UBL4B 0.97013660517434 0 1.94027321034868 Inf Inf 0.496193947515089 1 0 0 0.116143 0 GeneID:164153,Genbank:NM_203412.1,HGNC:HGNC:32309,MIM:611127 ubiquitin like 4B GO:0005737,GO:1903955 cytoplasm|positive regulation of protein targeting to mitochondrion UBL5 2167.90312163545 2178.11904726075 2157.68719601015 0.990619497462137 -0.0135970783819082 0.951491381618683 1 129.324 139.779 108.008 159.674 GeneID:59286,Genbank:NM_001048241.2,HGNC:HGNC:13736,MIM:606849 ubiquitin like 5 GO:0005737,GO:1903955 cytoplasm|positive regulation of protein targeting to mitochondrion UBL7 1198.95250136278 1198.47277810655 1199.432224619 1.00080055761798 0.00115449844577743 0.98708625108429 1 20.0673 21.834 21.3958 20.8114 GeneID:84993,Genbank:XM_024450093.1,HGNC:HGNC:28221,MIM:609748 ubiquitin like 7 UBLCP1 264.171786592019 254.99472314697 273.348850037067 1.07197845768564 0.100275913909147 0.726577452258026 1 4.88436 3.22974 4.82617 3.83124 GeneID:134510,Genbank:NM_145049.4,HGNC:HGNC:28110,MIM:609867 ubiquitin like domain containing CTD phosphatase 1 GO:0004722,GO:0005634,GO:0005730,GO:0006470 protein serine/threonine phosphatase activity|nucleus|nucleolus|protein dephosphorylation UBN1 1715.87028654587 1656.48828083025 1775.25229226149 1.07169625816593 0.0998960728381341 0.492404488123355 1 8.12146 8.29806 9.52499 8.47346 GeneID:29855,Genbank:XM_005255278.3,HGNC:HGNC:12506,MIM:609771 ubinuclein 1 GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005923,GO:0006336,GO:0006357,GO:0016032,GO:0016569,GO:0016604,GO:0016605 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|bicellular tight junction|DNA replication-independent nucleosome assembly|regulation of transcription from RNA polymerase II promoter|viral process|covalent chromatin modification|nuclear body|PML body UBN2 161.078986201264 182.081979461511 140.075992941017 0.769301791178227 -0.37837842748771 0.129303590101784 1 0.438365 0.400675 0.357627 0.259594 GeneID:254048,Genbank:XM_011516003.2,HGNC:HGNC:21931,MIM:613841 ubinuclein 2 GO:0005615,GO:0005654 extracellular space|nucleoplasm UBOX5 226.595614419323 222.988228542289 230.203000296357 1.0323549444795 0.0459390837448257 0.859282232909701 1 2.29862 2.38962 2.69515 2.34712 GeneID:22888,Genbank:NM_199415.2,HGNC:HGNC:17777 U-box domain containing 5 GO:0000209,GO:0005634,GO:0005654,GO:0005925,GO:0016604,GO:0031625,GO:0034450,GO:0046872 protein polyubiquitination|nucleus|nucleoplasm|focal adhesion|nuclear body|ubiquitin protein ligase binding|ubiquitin-ubiquitin ligase activity|metal ion binding hsa04120 Ubiquitin mediated proteolysis UBP1 2776.58413749122 2646.11318946295 2907.05508551948 1.09861327818312 0.13568363393716 0.345774970677858 1 25.8296 24.0055 31.478 24.5399 GeneID:7342,Genbank:NM_001128161.1,HGNC:HGNC:12507,MIM:609784 upstream binding protein 1 GO:0001525,GO:0003677,GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006357,GO:0019079,GO:0043565,GO:0045892 angiogenesis|DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|viral genome replication|sequence-specific DNA binding|negative regulation of transcription, DNA-templated UBQLN1 2732.86563723256 2855.8116552226 2609.91961924252 0.913897670551768 -0.129895459639351 0.35592794835698 1 23.125 21.6746 22.6491 18.2396 GeneID:29979,Genbank:NM_053067.2,HGNC:HGNC:12508,MIM:605046 ubiquilin 1 GO:0000045,GO:0000502,GO:0005654,GO:0005737,GO:0005776,GO:0005783,GO:0005829,GO:0005886,GO:0016235,GO:0016236,GO:0019900,GO:0030433,GO:0031396,GO:0031398,GO:0031410,GO:0031593,GO:0034140,GO:0034976,GO:0035973,GO:0042802,GO:0043234,GO:0048471,GO:0071456,GO:0097352,GO:1901340,GO:1902175,GO:1903071 autophagosome assembly|proteasome complex|nucleoplasm|cytoplasm|autophagosome|endoplasmic reticulum|cytosol|plasma membrane|aggresome|macroautophagy|kinase binding|ubiquitin-dependent ERAD pathway|regulation of protein ubiquitination|positive regulation of protein ubiquitination|cytoplasmic vesicle|polyubiquitin modification-dependent protein binding|negative regulation of toll-like receptor 3 signaling pathway|response to endoplasmic reticulum stress|aggrephagy|identical protein binding|protein complex|perinuclear region of cytoplasm|cellular response to hypoxia|autophagosome maturation|negative regulation of store-operated calcium channel activity|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|positive regulation of ER-associated ubiquitin-dependent protein catabolic process hsa04141 Protein processing in endoplasmic reticulum UBQLN2 578.406379420669 589.284960861664 567.527797979674 0.963078706691961 -0.0542743891195858 0.76815936104429 1 8.6391 7.79521 8.59909 7.38635 GeneID:29978,Genbank:NM_013444.3,HGNC:HGNC:12509,MIM:300264 ubiquilin 2 GO:0005634,GO:0005737,GO:0005776,GO:0005829,GO:0005886,GO:0006914,GO:0016241,GO:0030433,GO:0031410,GO:1900186,GO:1903071,GO:1904021,GO:2000785 nucleus|cytoplasm|autophagosome|cytosol|plasma membrane|autophagy|regulation of macroautophagy|ubiquitin-dependent ERAD pathway|cytoplasmic vesicle|negative regulation of clathrin-dependent endocytosis|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of G-protein coupled receptor internalization|regulation of autophagosome assembly hsa04141 Protein processing in endoplasmic reticulum UBQLN4 1899.1266297816 1876.20970569311 1922.04355387008 1.02442895804126 0.0348199400004145 0.821215682401656 1 15.6214 16.6547 17.4418 16.6542 GeneID:56893,Genbank:XM_024448469.1,HGNC:HGNC:1237,MIM:605440 ubiquilin 4 GO:0005634,GO:0005737,GO:0005776,GO:0005789,GO:0005829,GO:0006914,GO:0031410,GO:0031593,GO:0032434,GO:0042802,GO:0048471,GO:1901097 nucleus|cytoplasm|autophagosome|endoplasmic reticulum membrane|cytosol|autophagy|cytoplasmic vesicle|polyubiquitin modification-dependent protein binding|regulation of proteasomal ubiquitin-dependent protein catabolic process|identical protein binding|perinuclear region of cytoplasm|negative regulation of autophagosome maturation hsa04141 Protein processing in endoplasmic reticulum UBQLNL 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0147448 0 GeneID:143630,Genbank:NM_145053.4,HGNC:HGNC:28294 ubiquilin like UBR1 557.664835074927 553.5391744841 561.790495665754 1.01490648098998 0.0213467957573429 0.937199101731373 1 2.59526 2.46751 3.17252 2.02069 GeneID:197131,Genbank:NM_174916.2,HGNC:HGNC:16808,MIM:605981 ubiquitin protein ligase E3 component n-recognin 1 GO:0000151,GO:0000502,GO:0005737,GO:0005829,GO:0008270,GO:0032007,GO:0061630,GO:0070728,GO:0071233,GO:0071596 ubiquitin ligase complex|proteasome complex|cytoplasm|cytosol|zinc ion binding|negative regulation of TOR signaling|ubiquitin protein ligase activity|leucine binding|cellular response to leucine|ubiquitin-dependent protein catabolic process via the N-end rule pathway UBR2 439.955760690432 462.58003282048 417.331488560384 0.902182236478728 -0.148509214501058 0.544578594791498 1 1.75089 1.70796 1.87249 1.2197 GeneID:23304,Genbank:XM_005248965.4,HGNC:HGNC:21289,MIM:609134 ubiquitin protein ligase E3 component n-recognin 2 GO:0000151,GO:0000209,GO:0000785,GO:0004842,GO:0005634,GO:0005737,GO:0005829,GO:0006342,GO:0007131,GO:0007140,GO:0007141,GO:0007283,GO:0008270,GO:0010529,GO:0032007,GO:0033522,GO:0061630,GO:0070728,GO:0071233,GO:0071596 ubiquitin ligase complex|protein polyubiquitination|chromatin|ubiquitin-protein transferase activity|nucleus|cytoplasm|cytosol|chromatin silencing|reciprocal meiotic recombination|male meiotic nuclear division|male meiosis I|spermatogenesis|zinc ion binding|negative regulation of transposition|negative regulation of TOR signaling|histone H2A ubiquitination|ubiquitin protein ligase activity|leucine binding|cellular response to leucine|ubiquitin-dependent protein catabolic process via the N-end rule pathway UBR3 304.564921045136 314.388398332326 294.741443757946 0.937507380429438 -0.0930980468799733 0.878381934673484 1 1.47053 1.10718 1.5763 0.742971 GeneID:130507,Genbank:XM_006712268.4,HGNC:HGNC:30467,MIM:613831 ubiquitin protein ligase E3 component n-recognin 3 (putative) GO:0000151,GO:0001701,GO:0001967,GO:0004842,GO:0005737,GO:0006511,GO:0007608,GO:0008270,GO:0009790,GO:0016021,GO:0042048,GO:0061630,GO:0071596 ubiquitin ligase complex|in utero embryonic development|suckling behavior|ubiquitin-protein transferase activity|cytoplasm|ubiquitin-dependent protein catabolic process|sensory perception of smell|zinc ion binding|embryo development|integral component of membrane|olfactory behavior|ubiquitin protein ligase activity|ubiquitin-dependent protein catabolic process via the N-end rule pathway UBR4 6697.22729505028 6740.87773740585 6653.57685269472 0.98704903306187 -0.0188063405014125 0.877980595611785 1 10.3848 10.9314 11.9613 9.34843 GeneID:23352,Genbank:NM_020765.2,HGNC:HGNC:30313,MIM:609890 ubiquitin protein ligase E3 component n-recognin 4 GO:0004842,GO:0005516,GO:0005654,GO:0005813,GO:0005829,GO:0005886,GO:0008270,GO:0016020,GO:0016021,GO:0016032,GO:0035579,GO:0042787,GO:0043312,GO:0070821,GO:0101003 ubiquitin-protein transferase activity|calmodulin binding|nucleoplasm|centrosome|cytosol|plasma membrane|zinc ion binding|membrane|integral component of membrane|viral process|specific granule membrane|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|neutrophil degranulation|tertiary granule membrane|ficolin-1-rich granule membrane hsa05165,hsa05203 Human papillomavirus infection|Viral carcinogenesis UBR5 870.439775600168 882.485636051093 858.393915149243 0.972700155200651 -0.0399329468928232 0.884579570896508 1 2.70838 2.46292 2.95872 2.04777 GeneID:51366,Genbank:NM_001282873.1,HGNC:HGNC:16806,MIM:608413 ubiquitin protein ligase E3 component n-recognin 5 GO:0000209,GO:0003723,GO:0004842,GO:0005634,GO:0005654,GO:0005829,GO:0006281,GO:0006511,GO:0006974,GO:0008270,GO:0008283,GO:0010628,GO:0016020,GO:0033160,GO:0034450,GO:0035413,GO:0043130,GO:0043234,GO:0048471,GO:0050847,GO:0090263,GO:1901315,GO:2000780 protein polyubiquitination|RNA binding|ubiquitin-protein transferase activity|nucleus|nucleoplasm|cytosol|DNA repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|zinc ion binding|cell proliferation|positive regulation of gene expression|membrane|positive regulation of protein import into nucleus, translocation|ubiquitin-ubiquitin ligase activity|positive regulation of catenin import into nucleus|ubiquitin binding|protein complex|perinuclear region of cytoplasm|progesterone receptor signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of histone H2A K63-linked ubiquitination|negative regulation of double-strand break repair hsa04120 Ubiquitin mediated proteolysis UBR7 1676.4901527645 1602.46475675535 1750.51554877365 1.09238942160455 0.127487248625801 0.368151774273948 1 17.8571 17.7207 20.455 18.6414 GeneID:55148,Genbank:NM_175748.3,HGNC:HGNC:20344,MIM:613816 ubiquitin protein ligase E3 component n-recognin 7 (putative) GO:0008270,GO:0016567,GO:0016740 zinc ion binding|protein ubiquitination|transferase activity UBTD1 720.788030920827 704.460531975897 737.115529865756 1.04635461662879 0.0653718735246448 0.706917196114039 1 20.219 20.2097 22.4079 21.4722 GeneID:80019,Genbank:NM_024954.4,HGNC:HGNC:25683,MIM:616388 ubiquitin domain containing 1 GO:0043130 ubiquitin binding UBTD2 843.450597725158 830.521501135961 856.379694314355 1.03113488710771 0.0442330700799621 0.790359826630067 1 9.89465 10.7744 11.4956 9.75866 GeneID:92181,Genbank:XM_017010022.1,HGNC:HGNC:24463,MIM:610174 ubiquitin domain containing 2 GO:0005737,GO:0043130 cytoplasm|ubiquitin binding UBTF 3273.42071293938 3214.11945963662 3332.72196624214 1.03690046623809 0.0522774141544822 0.716305884394745 1 15.7229 16.5265 16.7358 16.6039 GeneID:7343,Genbank:NM_001076683.1,HGNC:HGNC:12511,MIM:600673 upstream binding transcription factor GO:0001164,GO:0001165,GO:0001650,GO:0003682,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006356,GO:0006360,GO:0006361,GO:0006362,GO:0006363,GO:0045943,GO:0097110 RNA polymerase I CORE element sequence-specific DNA binding|RNA polymerase I upstream control element sequence-specific DNA binding|fibrillar center|chromatin binding|RNA binding|nucleus|nucleoplasm|nucleolus|regulation of transcription from RNA polymerase I promoter|transcription from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|positive regulation of transcription from RNA polymerase I promoter|scaffold protein binding UBXN1 1479.17965988814 1508.97983984365 1449.37947993263 0.960502878608903 -0.0581381572604169 0.739222380000137 1 32.4112 33.8725 29.9029 34.4153 GeneID:51035,Genbank:NM_001286078.1,HGNC:HGNC:18402,MIM:616378 UBX domain protein 1 GO:0005634,GO:0005737,GO:0005783,GO:0005829,GO:0006457,GO:0030425,GO:0031397,GO:0031593,GO:0031625,GO:0032435,GO:0034098,GO:0036435,GO:0043025,GO:0043130,GO:0043161,GO:0051117,GO:0071796,GO:1903094,GO:1904293,GO:2000157 nucleus|cytoplasm|endoplasmic reticulum|cytosol|protein folding|dendrite|negative regulation of protein ubiquitination|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|VCP-NPL4-UFD1 AAA ATPase complex|K48-linked polyubiquitin modification-dependent protein binding|neuronal cell body|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ATPase binding|K6-linked polyubiquitin modification-dependent protein binding|negative regulation of protein K48-linked deubiquitination|negative regulation of ERAD pathway|negative regulation of ubiquitin-specific protease activity UBXN11 247.603148546161 254.85166132377 240.354635768552 0.943115828714176 -0.0844931286003661 0.696583353126998 1 3.61249 3.3127 3.03658 3.48979 GeneID:91544,Genbank:NM_145345.2,HGNC:HGNC:30600,MIM:609151 UBX domain protein 11 GO:0005737,GO:0005856,GO:0043130,GO:0043161 cytoplasm|cytoskeleton|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process UBXN2A 471.393109627888 459.591578134051 483.194641121724 1.05135660466953 0.0722520932085501 0.674381602082597 1 4.96706 4.90627 5.64141 4.7437 GeneID:165324,Genbank:XM_005264168.5,HGNC:HGNC:27265 UBX domain protein 2A GO:0000045,GO:0005634,GO:0005783,GO:0005801,GO:0005829,GO:0007030,GO:0010468,GO:0019888,GO:0031396,GO:0031468,GO:0033130,GO:0042176,GO:0043130,GO:0043161,GO:0061025,GO:1990830 autophagosome assembly|nucleus|endoplasmic reticulum|cis-Golgi network|cytosol|Golgi organization|regulation of gene expression|protein phosphatase regulator activity|regulation of protein ubiquitination|nuclear envelope reassembly|acetylcholine receptor binding|regulation of protein catabolic process|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|membrane fusion|cellular response to leukemia inhibitory factor UBXN2B 614.908282826495 662.756436534836 567.060129118154 0.855608633667865 -0.224977054545497 0.17710170907368 1 5.06593 5.25842 4.85131 3.98878 GeneID:137886,Genbank:NM_001077619.1,HGNC:HGNC:27035,MIM:610686 UBX domain protein 2B GO:0000045,GO:0005634,GO:0005783,GO:0005794,GO:0005829,GO:0007030,GO:0019888,GO:0031468,GO:0043130,GO:0043161,GO:0061025 autophagosome assembly|nucleus|endoplasmic reticulum|Golgi apparatus|cytosol|Golgi organization|protein phosphatase regulator activity|nuclear envelope reassembly|ubiquitin binding|proteasome-mediated ubiquitin-dependent protein catabolic process|membrane fusion UBXN4 1206.68151832888 1230.23609033524 1183.12694632252 0.961707232958932 -0.0563303254680807 0.858253582069784 1 13.2067 10.864 13.6102 9.63001 GeneID:23190,Genbank:NM_014607.3,HGNC:HGNC:14860,MIM:611216 UBX domain protein 4 GO:0005635,GO:0005783,GO:0005789,GO:0005829,GO:0006986,GO:0030433 nuclear envelope|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|response to unfolded protein|ubiquitin-dependent ERAD pathway UBXN6 2634.81486848545 2438.08212801219 2831.54760895872 1.16138319395636 0.215844062477464 0.124055028391008 1 30.3589 32.8148 36.3263 39.1657 GeneID:80700,Genbank:XM_017027325.1,HGNC:HGNC:14928,MIM:611946 UBX domain protein 6 GO:0005634,GO:0005737,GO:0005765,GO:0005815,GO:0005829,GO:0016236,GO:0019898,GO:0031901,GO:0031902,GO:0032510,GO:0036503,GO:0043234,GO:0070062 nucleus|cytoplasm|lysosomal membrane|microtubule organizing center|cytosol|macroautophagy|extrinsic component of membrane|early endosome membrane|late endosome membrane|endosome to lysosome transport via multivesicular body sorting pathway|ERAD pathway|protein complex|extracellular exosome hsa04141 Protein processing in endoplasmic reticulum UBXN7 982.691750783548 978.96983330519 986.413668261906 1.00760374293821 0.0109283863634005 0.960681555374673 1 4.09466 3.51392 4.80236 2.94256 GeneID:26043,Genbank:XM_011512670.2,HGNC:HGNC:29119,MIM:616379 UBX domain protein 7 GO:0005654,GO:0005829,GO:0008134,GO:0016604,GO:0031625,GO:0034098,GO:0043130,GO:0043687 nucleoplasm|cytosol|transcription factor binding|nuclear body|ubiquitin protein ligase binding|VCP-NPL4-UFD1 AAA ATPase complex|ubiquitin binding|post-translational protein modification UBXN8 255.539649763781 300.753659972637 210.325639554924 0.699328611908031 -0.51595756293924 0.0152091757524837 0.511744031201217 3.7836 3.06418 2.45081 2.46438 GeneID:7993,Genbank:XM_011544655.2,HGNC:HGNC:30307,MIM:602155 UBX domain protein 8 GO:0005654,GO:0005730,GO:0005783,GO:0007338,GO:0030176,GO:0030433 nucleoplasm|nucleolus|endoplasmic reticulum|single fertilization|integral component of endoplasmic reticulum membrane|ubiquitin-dependent ERAD pathway UCHL1 24353.8818347756 23581.9687113136 25125.7949582377 1.06546638517858 0.0914850776807675 0.518966056430382 1 837.749 894.551 883.075 973.343 GeneID:7345,Genbank:NM_004181.4,HGNC:HGNC:12513,MIM:191342 ubiquitin C-terminal hydrolase L1 hsa05012 Parkinson disease UCHL3 377.035003317774 422.606917269787 331.463089365761 0.784329540810992 -0.350468156104211 0.0598806043294931 0.879410748501007 2.17505 2.57284 1.71679 2.03381 GeneID:7347,Genbank:NM_001270952.1,HGNC:HGNC:12515,MIM:603090 ubiquitin C-terminal hydrolase L3 GO:0004843,GO:0005634,GO:0005737,GO:0005829,GO:0006511,GO:0008233,GO:0016567,GO:0016579,GO:0019784,GO:0030163,GO:0036459,GO:0043130,GO:0043687,GO:0070062 thiol-dependent ubiquitin-specific protease activity|nucleus|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|peptidase activity|protein ubiquitination|protein deubiquitination|NEDD8-specific protease activity|protein catabolic process|thiol-dependent ubiquitinyl hydrolase activity|ubiquitin binding|post-translational protein modification|extracellular exosome UCHL5 454.357543331391 508.395787575085 400.319299087697 0.787416632614357 -0.344800907997703 0.0566471852234375 0.865163284430535 1.73521 1.74907 1.62249 1.33704 GeneID:51377,Genbank:NM_001350844.1,HGNC:HGNC:19678,MIM:610667 ubiquitin C-terminal hydrolase L5 GO:0003723,GO:0004843,GO:0004866,GO:0005634,GO:0005654,GO:0005739,GO:0005829,GO:0006281,GO:0006310,GO:0006351,GO:0006355,GO:0006511,GO:0016579,GO:0021670,GO:0030901,GO:0031011,GO:0031597,GO:0048853,GO:0061136,GO:0070628 RNA binding|thiol-dependent ubiquitin-specific protease activity|endopeptidase inhibitor activity|nucleus|nucleoplasm|mitochondrion|cytosol|DNA repair|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|protein deubiquitination|lateral ventricle development|midbrain development|Ino80 complex|cytosolic proteasome complex|forebrain morphogenesis|regulation of proteasomal protein catabolic process|proteasome binding UCK1 958.3685469973 889.876958701739 1026.86013529286 1.15393496286382 0.206561914279806 0.184846117077133 1 13.3381 13.2611 14.7285 16.805 GeneID:83549,Genbank:NM_001261450.2,HGNC:HGNC:14859,MIM:609328 uridine-cytidine kinase 1 GO:0004849,GO:0005524,GO:0005829,GO:0006206,GO:0019206,GO:0043097,GO:0044206,GO:0044211 uridine kinase activity|ATP binding|cytosol|pyrimidine nucleobase metabolic process|nucleoside kinase activity|pyrimidine nucleoside salvage|UMP salvage|CTP salvage hsa00240,hsa00983 Pyrimidine metabolism|Drug metabolism - other enzymes UCK2 1327.13327226343 1420.81603076686 1233.45051376 0.868128235500179 -0.204019928881754 0.162263282597286 1 9.69566 9.97965 9.67134 8.30876 GeneID:7371,Genbank:NM_012474.4,HGNC:HGNC:12562,MIM:609329 uridine-cytidine kinase 2 GO:0004849,GO:0005524,GO:0005829,GO:0006206,GO:0006238,GO:0019206,GO:0043097,GO:0044206,GO:0044211 uridine kinase activity|ATP binding|cytosol|pyrimidine nucleobase metabolic process|CMP salvage|nucleoside kinase activity|pyrimidine nucleoside salvage|UMP salvage|CTP salvage hsa00240,hsa00983 Pyrimidine metabolism|Drug metabolism - other enzymes UCKL1 859.145389508398 907.067675389824 811.223103626972 0.894335809374244 -0.161111451899468 0.294795034303266 1 1.89724 1.9447 1.76695 1.83811 GeneID:54963,Genbank:NM_001353481.1,HGNC:HGNC:15938,MIM:610866 uridine-cytidine kinase 1 like 1 GO:0004849,GO:0005524,GO:0005634,GO:0005829,GO:0006206,GO:0016032,GO:0043097,GO:0044206,GO:0044211 uridine kinase activity|ATP binding|nucleus|cytosol|pyrimidine nucleobase metabolic process|viral process|pyrimidine nucleoside salvage|UMP salvage|CTP salvage hsa00240,hsa00983 Pyrimidine metabolism|Drug metabolism - other enzymes UCN 15.306652558046 17.5269006108793 13.0864045052128 0.746646814274159 -0.421502127361018 0.596484388493519 1 1.15062 0.865074 0.943409 0.685414 GeneID:7349,Genbank:NM_003353.3,HGNC:HGNC:12516,MIM:600945 urocortin GO:0001964,GO:0005184,GO:0005576,GO:0006954,GO:0006979,GO:0007186,GO:0007218,GO:0007565,GO:0007605,GO:0008306,GO:0009060,GO:0010629,GO:0010996,GO:0030157,GO:0030307,GO:0030425,GO:0031175,GO:0032099,GO:0032355,GO:0032755,GO:0032967,GO:0033138,GO:0034199,GO:0035176,GO:0035483,GO:0042756,GO:0043066,GO:0043117,GO:0043196,GO:0043204,GO:0043679,GO:0043950,GO:0045727,GO:0045740,GO:0045776,GO:0045792,GO:0045944,GO:0046811,GO:0046888,GO:0048265,GO:0051384,GO:0051430,GO:0051431,GO:0051461,GO:0051966,GO:0060452,GO:0060455,GO:0060547,GO:0090280,GO:0097755,GO:1901215,GO:2000252,GO:2000987 startle response|neuropeptide hormone activity|extracellular region|inflammatory response|response to oxidative stress|G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|female pregnancy|sensory perception of sound|associative learning|aerobic respiration|negative regulation of gene expression|response to auditory stimulus|pancreatic juice secretion|positive regulation of cell growth|dendrite|neuron projection development|negative regulation of appetite|response to estradiol|positive regulation of interleukin-6 production|positive regulation of collagen biosynthetic process|positive regulation of peptidyl-serine phosphorylation|activation of protein kinase A activity|social behavior|gastric emptying|drinking behavior|negative regulation of apoptotic process|positive regulation of vascular permeability|varicosity|perikaryon|axon terminus|positive regulation of cAMP-mediated signaling|positive regulation of translation|positive regulation of DNA replication|negative regulation of blood pressure|negative regulation of cell size|positive regulation of transcription from RNA polymerase II promoter|histone deacetylase inhibitor activity|negative regulation of hormone secretion|response to pain|response to glucocorticoid|corticotropin-releasing hormone receptor 1 binding|corticotropin-releasing hormone receptor 2 binding|positive regulation of corticotropin secretion|regulation of synaptic transmission, glutamatergic|positive regulation of cardiac muscle contraction|negative regulation of gastric acid secretion|negative regulation of necrotic cell death|positive regulation of calcium ion import|positive regulation of blood vessel diameter|negative regulation of neuron death|negative regulation of feeding behavior|positive regulation of behavioral fear response UCN2 30.4536736414249 32.3152865638621 28.5920607189877 0.884784377897549 -0.176602181883349 0.757612471408481 1 1.18667 1.19778 1.0489 1.02717 GeneID:90226,Genbank:NM_033199.3,HGNC:HGNC:18414,MIM:605902 urocortin 2 GO:0001664,GO:0005179,GO:0005576,GO:0005615,GO:0005622,GO:0006950,GO:0007189,GO:0007586,GO:0009755,GO:0031669,GO:0042562,GO:0051429,GO:0051431 G-protein coupled receptor binding|hormone activity|extracellular region|extracellular space|intracellular|response to stress|adenylate cyclase-activating G-protein coupled receptor signaling pathway|digestion|hormone-mediated signaling pathway|cellular response to nutrient levels|hormone binding|corticotropin-releasing hormone receptor binding|corticotropin-releasing hormone receptor 2 binding hsa04080 Neuroactive ligand-receptor interaction UCP2 234.311093698509 241.321767167704 227.300420229315 0.941897711495519 -0.0863577007933077 0.712774326138907 1 5.70483 4.47162 5.40923 4.86768 GeneID:7351,Genbank:XM_024448674.1,HGNC:HGNC:12518,MIM:601693 uncoupling protein 2 UCP3 6.50845823812006 7.68725495215503 5.32966152408509 0.693311404039095 -0.528424603774571 0.695785428719125 1 0.0622847 0.0664027 0.0391839 0.036602 GeneID:7352,Genbank:NM_003356.3,HGNC:HGNC:12519,MIM:602044 uncoupling protein 3 GO:0000303,GO:0001666,GO:0005215,GO:0005739,GO:0005743,GO:0006629,GO:0006631,GO:0006839,GO:0007568,GO:0007584,GO:0007585,GO:0009409,GO:0014823,GO:0015992,GO:0016021,GO:0017077,GO:0032868,GO:0032870,GO:0051384,GO:1990542,GO:1990845 response to superoxide|response to hypoxia|transporter activity|mitochondrion|mitochondrial inner membrane|lipid metabolic process|fatty acid metabolic process|mitochondrial transport|aging|response to nutrient|respiratory gaseous exchange|response to cold|response to activity|proton transport|integral component of membrane|oxidative phosphorylation uncoupler activity|response to insulin|cellular response to hormone stimulus|response to glucocorticoid|mitochondrial transmembrane transport|adaptive thermogenesis UEVLD 295.024561697671 328.812191398046 261.236931997296 0.794486758190342 -0.331904920690948 0.103484394335585 1 2.34508 2.26321 2.12767 1.53013 GeneID:55293,Genbank:NM_001261384.2,HGNC:HGNC:30866,MIM:610985 UEV and lactate/malate dehyrogenase domains GO:0005975,GO:0006464,GO:0015031,GO:0016616,GO:0019752,GO:0070062 carbohydrate metabolic process|cellular protein modification process|protein transport|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|carboxylic acid metabolic process|extracellular exosome UFC1 2253.61876957765 2285.28469480512 2221.95284435018 0.972287106897927 -0.0405457043730985 0.779884498262214 1 53.9718 51.6175 51.7482 52.0446 GeneID:51506,Genbank:XM_017001450.2,HGNC:HGNC:26941,MIM:610554 ubiquitin-fold modifier conjugating enzyme 1 GO:0005737,GO:0034976,GO:0070062,GO:0071568,GO:0071569,GO:1990592 cytoplasm|response to endoplasmic reticulum stress|extracellular exosome|UFM1 transferase activity|protein ufmylation|protein K69-linked ufmylation UFD1 1772.11724046459 1629.05409097575 1915.18038995343 1.17563953251319 0.233445777543371 0.102171623448996 1 22.9661 23.5052 28.2254 27.8078 GeneID:7353,Genbank:NM_001035247.2,HGNC:HGNC:12520,MIM:601754 ubiquitin recognition factor in ER associated degradation 1 GO:0001501,GO:0004843,GO:0005102,GO:0005634,GO:0005654,GO:0005783,GO:0005829,GO:0006511,GO:0016579,GO:0030970,GO:0032403,GO:0032480,GO:0034098,GO:0036435,GO:0036501,GO:0039536,GO:0043161,GO:0051117,GO:0070987,GO:0071712 skeletal system development|thiol-dependent ubiquitin-specific protease activity|receptor binding|nucleus|nucleoplasm|endoplasmic reticulum|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|retrograde protein transport, ER to cytosol|protein complex binding|negative regulation of type I interferon production|VCP-NPL4-UFD1 AAA ATPase complex|K48-linked polyubiquitin modification-dependent protein binding|UFD1-NPL4 complex|negative regulation of RIG-I signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|ATPase binding|error-free translesion synthesis|ER-associated misfolded protein catabolic process hsa04141 Protein processing in endoplasmic reticulum UFL1 216.746691718004 229.42578335178 204.067600084228 0.889471083428009 -0.168980390432727 0.578676905140839 1 2.17582 2.06196 2.36099 1.45006 GeneID:23376,Genbank:NM_015323.4,HGNC:HGNC:23039,MIM:613372 UFM1 specific ligase 1 GO:0001649,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0008284,GO:0016020,GO:0016874,GO:0031397,GO:0032088,GO:0032434,GO:0032880,GO:0033146,GO:0034976,GO:0043005,GO:0043066,GO:0043234,GO:0060252,GO:0071568,GO:0071569,GO:1902065,GO:1990592 osteoblast differentiation|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|positive regulation of cell proliferation|membrane|ligase activity|negative regulation of protein ubiquitination|negative regulation of NF-kappaB transcription factor activity|regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of protein localization|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|neuron projection|negative regulation of apoptotic process|protein complex|positive regulation of glial cell proliferation|UFM1 transferase activity|protein ufmylation|response to L-glutamate|protein K69-linked ufmylation UFM1 719.650812489071 802.932406801439 636.369218176702 0.792556400496703 -0.335414489828861 0.0406761025652667 0.759435523043776 9.74002 8.9002 8.50294 6.42065 GeneID:51569,Genbank:NM_001286704.1,HGNC:HGNC:20597,MIM:610553 ubiquitin fold modifier 1 GO:0005634,GO:0005737,GO:0005783,GO:0033146,GO:0034976,GO:0043066,GO:0070062,GO:0071569,GO:1990592 nucleus|cytoplasm|endoplasmic reticulum|regulation of intracellular estrogen receptor signaling pathway|response to endoplasmic reticulum stress|negative regulation of apoptotic process|extracellular exosome|protein ufmylation|protein K69-linked ufmylation UFSP1 27.6453932734507 27.6645125728211 27.6262739740804 0.998617774354777 -0.00199550952390159 1 1 1.66979 1.7132 1.85645 1.4748 GeneID:402682,Genbank:NM_001015072.3,HGNC:HGNC:33821,MIM:611481 UFM1 specific peptidase 1 (inactive) GO:0016790,GO:0071567 thiolester hydrolase activity|UFM1 hydrolase activity UFSP2 335.46138797065 338.469540613138 332.453235328163 0.982224972817122 -0.0258745917377571 0.909390385601126 1 4.64154 4.80628 4.98975 4.62657 GeneID:55325,Genbank:NM_018359.3,HGNC:HGNC:25640,MIM:611482 UFM1 specific peptidase 2 GO:0005634,GO:0005737,GO:0005783,GO:0006508,GO:0016790,GO:0033146,GO:0071567 nucleus|cytoplasm|endoplasmic reticulum|proteolysis|thiolester hydrolase activity|regulation of intracellular estrogen receptor signaling pathway|UFM1 hydrolase activity UGCG 1029.16032329855 1294.99315897851 763.327487618585 0.589445189209103 -0.762570427454316 6.71351176964398e-07 0.000565913707908515 13.367 12.6776 8.12252 6.93722 GeneID:7357,Genbank:NM_003358.2,HGNC:HGNC:12524,MIM:602874 UDP-glucose ceramide glucosyltransferase GO:0000139,GO:0006679,GO:0006687,GO:0006688,GO:0008120,GO:0008544,GO:0016020,GO:0016021,GO:0102769,GO:1903955 Golgi membrane|glucosylceramide biosynthetic process|glycosphingolipid metabolic process|glycosphingolipid biosynthetic process|ceramide glucosyltransferase activity|epidermis development|membrane|integral component of membrane|dihydroceramide glucosyltransferase activity|positive regulation of protein targeting to mitochondrion hsa00600 Sphingolipid metabolism UGDH 682.508543843449 744.662953244052 620.354134442845 0.833067002649094 -0.263495560278333 0.114260891673021 1 9.94034 8.77018 8.0336 7.11084 GeneID:7358,Genbank:NM_001184700.1,HGNC:HGNC:12525,MIM:603370 UDP-glucose 6-dehydrogenase GO:0001702,GO:0003979,GO:0005634,GO:0005654,GO:0005829,GO:0006011,GO:0006024,GO:0006065,GO:0009055,GO:0051287,GO:0070062 gastrulation with mouth forming second|UDP-glucose 6-dehydrogenase activity|nucleus|nucleoplasm|cytosol|UDP-glucose metabolic process|glycosaminoglycan biosynthetic process|UDP-glucuronate biosynthetic process|electron transfer activity|NAD binding|extracellular exosome hsa00040,hsa00053,hsa00520 Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Amino sugar and nucleotide sugar metabolism UGGT1 2708.25399298596 2663.47842794127 2753.02955803065 1.03362187174108 0.0477085033164385 0.797628385523603 1 7.92415 8.12228 9.76946 7.15195 GeneID:56886,Genbank:NM_020120.3,HGNC:HGNC:15663,MIM:605897 UDP-glucose glycoprotein glucosyltransferase 1 GO:0003980,GO:0005783,GO:0005788,GO:0005793,GO:0018279,GO:0030968,GO:0043234,GO:0044322,GO:0051082,GO:0051084,GO:0070062,GO:0071712,GO:1904380 UDP-glucose:glycoprotein glucosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation via asparagine|endoplasmic reticulum unfolded protein response|protein complex|endoplasmic reticulum quality control compartment|unfolded protein binding|'de novo' posttranslational protein folding|extracellular exosome|ER-associated misfolded protein catabolic process|endoplasmic reticulum mannose trimming hsa04141 Protein processing in endoplasmic reticulum UGGT2 255.368021174037 266.448661835622 244.287380512453 0.916827199767135 -0.12527824932323 0.786804867599827 1 1.33459 0.969893 1.18355 0.870679 GeneID:55757,Genbank:NM_020121.3,HGNC:HGNC:15664,MIM:605898 UDP-glucose glycoprotein glucosyltransferase 2 GO:0003980,GO:0005783,GO:0005788,GO:0005793,GO:0018279,GO:0030968,GO:0043234,GO:0044322,GO:0051082,GO:0051084,GO:0071712,GO:1904380 UDP-glucose:glycoprotein glucosyltransferase activity|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation via asparagine|endoplasmic reticulum unfolded protein response|protein complex|endoplasmic reticulum quality control compartment|unfolded protein binding|'de novo' posttranslational protein folding|ER-associated misfolded protein catabolic process|endoplasmic reticulum mannose trimming hsa04141 Protein processing in endoplasmic reticulum UGP2 868.328497982356 904.989685920699 831.667310044012 0.918979876768327 -0.121894824237467 0.490612619063413 1 9.74992 7.83153 9.21133 7.59616 GeneID:7360,Genbank:NM_001001521.1,HGNC:HGNC:12527,MIM:191760 UDP-glucose pyrophosphorylase 2 GO:0003983,GO:0005536,GO:0005634,GO:0005737,GO:0005829,GO:0005977,GO:0005978,GO:0006011,GO:0006065,GO:0019255,GO:0032557,GO:0042802,GO:0046872,GO:0070062 UTP:glucose-1-phosphate uridylyltransferase activity|glucose binding|nucleus|cytoplasm|cytosol|glycogen metabolic process|glycogen biosynthetic process|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|glucose 1-phosphate metabolic process|pyrimidine ribonucleotide binding|identical protein binding|metal ion binding|extracellular exosome hsa00040,hsa00052,hsa00500,hsa00520 Pentose and glucuronate interconversions|Galactose metabolism|Starch and sucrose metabolism|Amino sugar and nucleotide sugar metabolism UGT1A10 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 6.66103e-09 0.0199277 4.68892e-09 1.29193e-07 GeneID:54575,Genbank:NM_019075.2,HGNC:HGNC:12531,MIM:606435 UDP glucuronosyltransferase family 1 member A10 GO:0005080,GO:0005783,GO:0005789,GO:0015020,GO:0016021,GO:0019899,GO:0042803,GO:0045922,GO:0046982,GO:0051552,GO:0052695,GO:0052696,GO:0052697,GO:1904224,GO:2001030 protein kinase C binding|endoplasmic reticulum|endoplasmic reticulum membrane|glucuronosyltransferase activity|integral component of membrane|enzyme binding|protein homodimerization activity|negative regulation of fatty acid metabolic process|protein heterodimerization activity|flavone metabolic process|cellular glucuronidation|flavonoid glucuronidation|xenobiotic glucuronidation|negative regulation of glucuronosyltransferase activity|negative regulation of cellular glucuronidation hsa00040,hsa00053,hsa00140,hsa00830,hsa00860,hsa00980,hsa00982,hsa00983,hsa05204 Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Steroid hormone biosynthesis|Retinol metabolism|Porphyrin and chlorophyll metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Chemical carcinogenesis UGT1A6 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 1.0138e-38 0.0340237 1.18438e-09 1.64015e-09 GeneID:54578,Genbank:NM_205862.1,HGNC:HGNC:12538,MIM:606431 UDP glucuronosyltransferase family 1 member A6 GO:0005783,GO:0005789,GO:0006805,GO:0015020,GO:0016021,GO:0019899,GO:0042803,GO:0045922,GO:0046982,GO:0052695,GO:0052696,GO:0052697,GO:0070062,GO:1904224,GO:2001030 endoplasmic reticulum|endoplasmic reticulum membrane|xenobiotic metabolic process|glucuronosyltransferase activity|integral component of membrane|enzyme binding|protein homodimerization activity|negative regulation of fatty acid metabolic process|protein heterodimerization activity|cellular glucuronidation|flavonoid glucuronidation|xenobiotic glucuronidation|extracellular exosome|negative regulation of glucuronosyltransferase activity|negative regulation of cellular glucuronidation hsa00040,hsa00053,hsa00140,hsa00830,hsa00860,hsa00980,hsa00982,hsa00983,hsa05204 Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Steroid hormone biosynthesis|Retinol metabolism|Porphyrin and chlorophyll metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Chemical carcinogenesis UGT1A7 0.972203168832738 0.490071401957362 1.45433493570811 2.96759804775273 1.56929569647876 0.837430708298891 1 0.00880076 0.0206288 0.0529467 0.0588797 GeneID:54577,Genbank:NM_019077.2,HGNC:HGNC:12539,MIM:606432 UDP glucuronosyltransferase family 1 member A7 GO:0001972,GO:0004857,GO:0005080,GO:0005783,GO:0005789,GO:0006631,GO:0007588,GO:0008144,GO:0009804,GO:0015020,GO:0016021,GO:0017144,GO:0019899,GO:0042573,GO:0042803,GO:0045922,GO:0046982,GO:0051552,GO:0052695,GO:0052696,GO:0052697,GO:1904224,GO:2001030 retinoic acid binding|enzyme inhibitor activity|protein kinase C binding|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|excretion|drug binding|coumarin metabolic process|glucuronosyltransferase activity|integral component of membrane|drug metabolic process|enzyme binding|retinoic acid metabolic process|protein homodimerization activity|negative regulation of fatty acid metabolic process|protein heterodimerization activity|flavone metabolic process|cellular glucuronidation|flavonoid glucuronidation|xenobiotic glucuronidation|negative regulation of glucuronosyltransferase activity|negative regulation of cellular glucuronidation hsa00040,hsa00053,hsa00140,hsa00830,hsa00860,hsa00980,hsa00982,hsa00983,hsa05204 Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Steroid hormone biosynthesis|Retinol metabolism|Porphyrin and chlorophyll metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Chemical carcinogenesis UGT1A8 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 3.68276e-07 0 0.0520588 2.35857e-07 GeneID:54576,Genbank:NM_019076.4,HGNC:HGNC:12540,MIM:606433 UDP glucuronosyltransferase family 1 member A8 GO:0001972,GO:0004857,GO:0005496,GO:0005504,GO:0005783,GO:0005789,GO:0006631,GO:0008144,GO:0008202,GO:0009804,GO:0015020,GO:0016021,GO:0017144,GO:0019899,GO:0042573,GO:0042803,GO:0045922,GO:0045939,GO:0046982,GO:0051552,GO:0052695,GO:0052696,GO:0052697,GO:1904224,GO:2001030 retinoic acid binding|enzyme inhibitor activity|steroid binding|fatty acid binding|endoplasmic reticulum|endoplasmic reticulum membrane|fatty acid metabolic process|drug binding|steroid metabolic process|coumarin metabolic process|glucuronosyltransferase activity|integral component of membrane|drug metabolic process|enzyme binding|retinoic acid metabolic process|protein homodimerization activity|negative regulation of fatty acid metabolic process|negative regulation of steroid metabolic process|protein heterodimerization activity|flavone metabolic process|cellular glucuronidation|flavonoid glucuronidation|xenobiotic glucuronidation|negative regulation of glucuronosyltransferase activity|negative regulation of cellular glucuronidation hsa00040,hsa00053,hsa00140,hsa00830,hsa00860,hsa00980,hsa00982,hsa00983,hsa05204 Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Steroid hormone biosynthesis|Retinol metabolism|Porphyrin and chlorophyll metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Chemical carcinogenesis UGT2B4 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0169386 0 0 0 GeneID:7363,Genbank:NM_001297616.1,HGNC:HGNC:12553,MIM:600067 UDP glucuronosyltransferase family 2 member B4 hsa00040,hsa00053,hsa00140,hsa00830,hsa00860,hsa00980,hsa00982,hsa00983,hsa04976,hsa05204 Pentose and glucuronate interconversions|Ascorbate and aldarate metabolism|Steroid hormone biosynthesis|Retinol metabolism|Porphyrin and chlorophyll metabolism|Metabolism of xenobiotics by cytochrome P450|Drug metabolism - cytochrome P450|Drug metabolism - other enzymes|Bile secretion|Chemical carcinogenesis UGT3A2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0172544 0 0 GeneID:167127,Genbank:NM_001168316.1,HGNC:HGNC:27266,MIM:616384 UDP glycosyltransferase family 3 member A2 GO:0008152,GO:0008194,GO:0015020,GO:0016021,GO:0043231,GO:0071412 metabolic process|UDP-glycosyltransferase activity|glucuronosyltransferase activity|integral component of membrane|intracellular membrane-bounded organelle|cellular response to genistein UGT8 360.232555474932 396.729185515416 323.735925434448 0.816012376336422 -0.293337061386944 0.125686657926043 1 1.84242 1.77167 1.547 1.42566 GeneID:7368,Genbank:XM_024454207.1,HGNC:HGNC:12555,MIM:601291 UDP glycosyltransferase 8 hsa00565,hsa00600 Ether lipid metabolism|Sphingolipid metabolism UHMK1 2380.38241561095 2775.74466925735 1985.02016196455 0.715130676084713 -0.483721204725509 0.208750834027686 1 18.4644 15.2459 15.7459 8.77205 GeneID:127933,Genbank:NM_001184763.1,HGNC:HGNC:19683,MIM:608849 U2AF homology motif kinase 1 GO:0000243,GO:0004674,GO:0005524,GO:0005634,GO:0005654,GO:0005794,GO:0007050,GO:0008187,GO:0016607,GO:0016740,GO:0018105,GO:0030424,GO:0030628,GO:0031175,GO:0032839,GO:0035770,GO:0043021,GO:0045948,GO:0046777,GO:0046825,GO:0071004,GO:0071598,GO:0089701 commitment complex|protein serine/threonine kinase activity|ATP binding|nucleus|nucleoplasm|Golgi apparatus|cell cycle arrest|poly-pyrimidine tract binding|nuclear speck|transferase activity|peptidyl-serine phosphorylation|axon|pre-mRNA 3'-splice site binding|neuron projection development|dendrite cytoplasm|ribonucleoprotein granule|ribonucleoprotein complex binding|positive regulation of translational initiation|protein autophosphorylation|regulation of protein export from nucleus|U2-type prespliceosome|neuronal ribonucleoprotein granule|U2AF UHRF1 3476.95850742642 3699.56036056058 3254.35665429226 0.879660375050387 -0.184981468642878 0.164098283660661 1 26.692 28.16 26.0216 23.4432 GeneID:29128,Genbank:NM_001290050.1,HGNC:HGNC:12556,MIM:607990 ubiquitin like with PHD and ring finger domains 1 UHRF1BP1 1229.10115731994 1192.76339207073 1265.43892256916 1.06093038316028 0.0853299916300693 0.563292449883466 1 4.69479 4.67027 5.45737 4.50574 GeneID:54887,Genbank:NM_017754.3,HGNC:HGNC:21216 UHRF1 binding protein 1 GO:0042802,GO:0042826 identical protein binding|histone deacetylase binding UHRF1BP1L 190.673372560068 200.069525509024 181.277219611111 0.906071122775444 -0.142303794673076 0.755064876552135 1 0.924076 0.631784 0.836646 0.595161 GeneID:23074,Genbank:XM_017019047.1,HGNC:HGNC:29102 UHRF1 binding protein 1 like UHRF2 645.04986374484 696.3782411703 593.721486319381 0.852584775368054 -0.230084801604181 0.166355394338506 1 6.19784 5.97585 5.73064 4.46789 GeneID:115426,Genbank:XM_017014253.1,HGNC:HGNC:12557,MIM:615211 ubiquitin like with PHD and ring finger domains 2 GO:0003677,GO:0004842,GO:0005634,GO:0005654,GO:0005720,GO:0007049,GO:0008283,GO:0010216,GO:0016567,GO:0030154,GO:0042393,GO:0046872,GO:0051726,GO:0051865,GO:0061630,GO:0071158,GO:0090308 DNA binding|ubiquitin-protein transferase activity|nucleus|nucleoplasm|nuclear heterochromatin|cell cycle|cell proliferation|maintenance of DNA methylation|protein ubiquitination|cell differentiation|histone binding|metal ion binding|regulation of cell cycle|protein autoubiquitination|ubiquitin protein ligase activity|positive regulation of cell cycle arrest|regulation of methylation-dependent chromatin silencing UIMC1 796.953296297648 809.746397155012 784.160195440284 0.968402203696586 -0.0463217325491503 0.771323750474819 1 4.62488 4.88645 4.82264 4.289 GeneID:51720,Genbank:NM_001199298.1,HGNC:HGNC:30298,MIM:609433 ubiquitin interaction motif containing 1 GO:0005634,GO:0005654,GO:0006302,GO:0006303,GO:0006351,GO:0010212,GO:0016579,GO:0016604,GO:0042393,GO:0045739,GO:0045892,GO:0070530,GO:0070531,GO:0070537,GO:0072425 nucleus|nucleoplasm|double-strand break repair|double-strand break repair via nonhomologous end joining|transcription, DNA-templated|response to ionizing radiation|protein deubiquitination|nuclear body|histone binding|positive regulation of DNA repair|negative regulation of transcription, DNA-templated|K63-linked polyubiquitin modification-dependent protein binding|BRCA1-A complex|histone H2A K63-linked deubiquitination|signal transduction involved in G2 DNA damage checkpoint hsa03440 Homologous recombination ULBP1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0101265 0 0 0 GeneID:80329,Genbank:XM_017011322.1,HGNC:HGNC:14893,MIM:605697 UL16 binding protein 1 GO:0003964,GO:0006310,GO:0009036,GO:0032197,GO:0032199,GO:0046872,GO:0090305 RNA-directed DNA polymerase activity|DNA recombination|Type II site-specific deoxyribonuclease activity|transposition, RNA-mediated|reverse transcription involved in RNA-mediated transposition|metal ion binding|nucleic acid phosphodiester bond hydrolysis hsa04650 Natural killer cell mediated cytotoxicity ULBP2 489.290565318353 484.748915768147 493.83221486856 1.01873815248461 0.0267832814776157 0.898622429644296 1 12.5396 13.653 13.6974 13.248 GeneID:80328,Genbank:NM_025217.3,HGNC:HGNC:14894,MIM:605698 UL16 binding protein 2 GO:0005576,GO:0005615,GO:0005783,GO:0005886,GO:0006501,GO:0009986,GO:0016032,GO:0030101,GO:0042267,GO:0046658,GO:0046703 extracellular region|extracellular space|endoplasmic reticulum|plasma membrane|C-terminal protein lipidation|cell surface|viral process|natural killer cell activation|natural killer cell mediated cytotoxicity|anchored component of plasma membrane|natural killer cell lectin-like receptor binding hsa04650 Natural killer cell mediated cytotoxicity ULBP3 203.132775118079 264.749141912288 141.516408323871 0.534530186959987 -0.903656670145121 7.03982814865736e-05 0.0194340897980463 2.71218 2.92111 1.53834 1.42988 GeneID:79465,Genbank:NM_024518.2,HGNC:HGNC:14895,MIM:605699 UL16 binding protein 3 GO:0005886,GO:0016032,GO:0030101,GO:0042267,GO:0046658,GO:0046703,GO:0050776 plasma membrane|viral process|natural killer cell activation|natural killer cell mediated cytotoxicity|anchored component of plasma membrane|natural killer cell lectin-like receptor binding|regulation of immune response hsa04650 Natural killer cell mediated cytotoxicity ULK1 645.479748822138 561.122602233487 729.836895410788 1.30067278078936 0.379258058973925 0.024507816251291 0.624739213180639 4.61679 5.2258 6.58934 6.53401 GeneID:8408,Genbank:NM_003565.2,HGNC:HGNC:12558,MIM:603168 unc-51 like autophagy activating kinase 1 GO:0004674,GO:0005524,GO:0005737,GO:0005741,GO:0005776,GO:0005789,GO:0005829,GO:0006468,GO:0006914,GO:0007165,GO:0008104,GO:0016236,GO:0016241,GO:0016301,GO:0017137,GO:0018105,GO:0018107,GO:0030424,GO:0031102,GO:0031175,GO:0031333,GO:0031669,GO:0032403,GO:0034045,GO:0042594,GO:0042802,GO:0046777,GO:0048675,GO:0051020,GO:0055037,GO:0075044,GO:0097629,GO:0097632,GO:0097635,GO:1990316,GO:2000786 protein serine/threonine kinase activity|ATP binding|cytoplasm|mitochondrial outer membrane|autophagosome|endoplasmic reticulum membrane|cytosol|protein phosphorylation|autophagy|signal transduction|protein localization|macroautophagy|regulation of macroautophagy|kinase activity|Rab GTPase binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|axon|neuron projection regeneration|neuron projection development|negative regulation of protein complex assembly|cellular response to nutrient levels|protein complex binding|phagophore assembly site membrane|response to starvation|identical protein binding|protein autophosphorylation|axon extension|GTPase binding|recycling endosome|autophagy of host cells involved in interaction with symbiont|extrinsic component of omegasome membrane|extrinsic component of phagophore assembly site membrane|extrinsic component of autophagosome membrane|Atg1/ULK1 kinase complex|positive regulation of autophagosome assembly hsa04137,hsa04140,hsa04150,hsa04152,hsa04211 Mitophagy - animal|Autophagy - animal|mTOR signaling pathway|AMPK signaling pathway|Longevity regulating pathway ULK2 316.718903463368 335.394842032447 298.042964894289 0.888633119961505 -0.170340182310802 0.388364862662 1 1.4449 1.48585 1.27701 1.23439 GeneID:9706,Genbank:XM_017025425.2,HGNC:HGNC:13480,MIM:608650 unc-51 like autophagy activating kinase 2 GO:0004674,GO:0005524,GO:0006914,GO:0007165,GO:0030659,GO:0034045,GO:0042594,GO:0046777,GO:0048671,GO:0048675,GO:0075044 protein serine/threonine kinase activity|ATP binding|autophagy|signal transduction|cytoplasmic vesicle membrane|phagophore assembly site membrane|response to starvation|protein autophosphorylation|negative regulation of collateral sprouting|axon extension|autophagy of host cells involved in interaction with symbiont hsa04136,hsa04140,hsa04150 Autophagy - other|Autophagy - animal|mTOR signaling pathway ULK3 846.265635918414 759.616052332161 932.915219504667 1.22814047523146 0.296475586220325 0.0597743613148296 0.879410748501007 8.16715 8.11017 10.4125 9.32858 GeneID:25989,Genbank:NM_001284365.2,HGNC:HGNC:19703,MIM:613472 unc-51 like kinase 3 GO:0000407,GO:0004674,GO:0005524,GO:0005737,GO:0006914,GO:0045879,GO:0045880,GO:0046777,GO:0090398,GO:0097542 phagophore assembly site|protein serine/threonine kinase activity|ATP binding|cytoplasm|autophagy|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway|protein autophosphorylation|cellular senescence|ciliary tip ULK4 72.3208003781231 70.0115498941472 74.630050862099 1.0659677006856 0.0921637244322872 0.794301308473037 1 0.301279 0.321123 0.356201 0.371729 GeneID:54986,Genbank:NM_001322501.1,HGNC:HGNC:15784,MIM:617010 unc-51 like kinase 4 GO:0000226,GO:0004674,GO:0005524,GO:0010975,GO:0043408,GO:0046328,GO:0090036,GO:1900744,GO:2001222 microtubule cytoskeleton organization|protein serine/threonine kinase activity|ATP binding|regulation of neuron projection development|regulation of MAPK cascade|regulation of JNK cascade|regulation of protein kinase C signaling|regulation of p38MAPK cascade|regulation of neuron migration UMAD1 276.230368722424 279.594345794208 272.86639165064 0.975936730321004 -0.0351404735447454 0.905438584065292 1 5.56813 4.89453 5.0855 4.38385 GeneID:729852,Genbank:NM_001302350.1,HGNC:HGNC:48955 UBAP1-MVB12-associated (UMA) domain containing 1 UMPS 950.116635832003 947.472010411827 952.761261252178 1.00558248769592 0.00803143043366056 0.940949382560848 1 6.4363 5.89956 6.24771 6.28036 GeneID:7372,Genbank:NM_000373.3,HGNC:HGNC:12563,MIM:613891 uridine monophosphate synthetase hsa00240,hsa00983 Pyrimidine metabolism|Drug metabolism - other enzymes UNC119 475.266943037928 453.807790860787 496.726095215068 1.09457374954465 0.130369162849463 0.476228966610684 1 8.26084 8.6728 10.3553 9.95838 GeneID:9094,Genbank:NM_001330166.1,HGNC:HGNC:12565,MIM:604011 unc-119 lipid binding chaperone GO:0000281,GO:0000922,GO:0005813,GO:0005829,GO:0006897,GO:0007268,GO:0007601,GO:0007602,GO:0008289,GO:0030182,GO:0042953,GO:0045171,GO:0051233,GO:0061098,GO:1900186,GO:2001287 mitotic cytokinesis|spindle pole|centrosome|cytosol|endocytosis|chemical synaptic transmission|visual perception|phototransduction|lipid binding|neuron differentiation|lipoprotein transport|intercellular bridge|spindle midzone|positive regulation of protein tyrosine kinase activity|negative regulation of clathrin-dependent endocytosis|negative regulation of caveolin-mediated endocytosis UNC119B 1105.7506229426 1045.46565649223 1166.03558939297 1.11532653622051 0.157466152493559 0.289081259646098 1 11.1187 10.4802 12.8031 11.6158 GeneID:84747,Genbank:NM_001080533.2,HGNC:HGNC:16488 unc-119 lipid binding chaperone B GO:0005622,GO:0005829,GO:0005929,GO:0008289,GO:0030182,GO:0035869,GO:0042953,GO:0060271 intracellular|cytosol|cilium|lipid binding|neuron differentiation|ciliary transition zone|lipoprotein transport|cilium assembly UNC13A 3.18728992245106 2.49838328447175 3.87619656043037 1.55148194615381 0.633646909018797 0.814995253323221 1 0 0.0124164 0.00325584 0.0151846 GeneID:23025,Genbank:XM_011527810.2,HGNC:HGNC:23150,MIM:609894 unc-13 homolog A GO:0001956,GO:0005509,GO:0005516,GO:0005543,GO:0005737,GO:0007269,GO:0007528,GO:0016079,GO:0016081,GO:0016082,GO:0016188,GO:0017075,GO:0019992,GO:0030054,GO:0031594,GO:0031915,GO:0035249,GO:0035556,GO:0042734,GO:0043005,GO:0043195,GO:0044305,GO:0047485,GO:0048172,GO:0048786,GO:0050435,GO:0051966,GO:0060384,GO:0099525,GO:1900451,GO:1902991,GO:1903861 positive regulation of neurotransmitter secretion|calcium ion binding|calmodulin binding|phospholipid binding|cytoplasm|neurotransmitter secretion|neuromuscular junction development|synaptic vesicle exocytosis|synaptic vesicle docking|synaptic vesicle priming|synaptic vesicle maturation|syntaxin-1 binding|diacylglycerol binding|cell junction|neuromuscular junction|positive regulation of synaptic plasticity|synaptic transmission, glutamatergic|intracellular signal transduction|presynaptic membrane|neuron projection|terminal bouton|calyx of Held|protein N-terminus binding|regulation of short-term neuronal synaptic plasticity|presynaptic active zone|amyloid-beta metabolic process|regulation of synaptic transmission, glutamatergic|innervation|presynaptic dense core vesicle exocytosis|positive regulation of glutamate receptor signaling pathway|regulation of amyloid precursor protein catabolic process|positive regulation of dendrite extension hsa04721 Synaptic vesicle cycle UNC13B 1916.31921743867 1684.25763760669 2148.38079727065 1.27556541784395 0.351136889986178 0.0128571452494606 0.464830786264924 4.12474 4.19422 5.50158 5.15538 GeneID:10497,Genbank:NM_001330653.1,HGNC:HGNC:12566,MIM:605836 unc-13 homolog B GO:0005509,GO:0005516,GO:0005543,GO:0005794,GO:0005829,GO:0005886,GO:0007268,GO:0007269,GO:0007528,GO:0010808,GO:0014047,GO:0016020,GO:0016079,GO:0016081,GO:0016082,GO:0017137,GO:0019992,GO:0030054,GO:0030742,GO:0031594,GO:0031914,GO:0032009,GO:0035249,GO:0035556,GO:0043065,GO:0043195,GO:0044305,GO:0048172,GO:0048786,GO:0050714,GO:0060384,GO:0071333,GO:0090382,GO:0097151,GO:0097470,GO:0099525,GO:1900426 calcium ion binding|calmodulin binding|phospholipid binding|Golgi apparatus|cytosol|plasma membrane|chemical synaptic transmission|neurotransmitter secretion|neuromuscular junction development|positive regulation of synaptic vesicle priming|glutamate secretion|membrane|synaptic vesicle exocytosis|synaptic vesicle docking|synaptic vesicle priming|Rab GTPase binding|diacylglycerol binding|cell junction|GTP-dependent protein binding|neuromuscular junction|negative regulation of synaptic plasticity|early phagosome|synaptic transmission, glutamatergic|intracellular signal transduction|positive regulation of apoptotic process|terminal bouton|calyx of Held|regulation of short-term neuronal synaptic plasticity|presynaptic active zone|positive regulation of protein secretion|innervation|cellular response to glucose stimulus|phagosome maturation|positive regulation of inhibitory postsynaptic potential|ribbon synapse|presynaptic dense core vesicle exocytosis|positive regulation of defense response to bacterium hsa04721 Synaptic vesicle cycle UNC13D 5.04368211764486 5.72696934432558 4.36039489096415 0.761379121975663 -0.393313085054359 0.852304914960123 1 0.0404097 0.0258794 0 0.0173749 GeneID:201294,Genbank:NM_199242.2,HGNC:HGNC:23147,MIM:608897 unc-13 homolog D UNC45A 2874.46004972399 2499.21354074046 3249.70655870752 1.30029167405387 0.378835276724639 0.00752375123502519 0.341216961574625 22.5819 23.2176 28.8957 32.3489 GeneID:55898,Genbank:XM_024449984.1,HGNC:HGNC:30594,MIM:611219 unc-45 myosin chaperone A GO:0005794,GO:0005829,GO:0007517,GO:0016607,GO:0030154,GO:0045296,GO:0048471,GO:0051879,GO:0061077 Golgi apparatus|cytosol|muscle organ development|nuclear speck|cell differentiation|cadherin binding|perinuclear region of cytoplasm|Hsp90 protein binding|chaperone-mediated protein folding UNC50 533.809678569204 568.46183060603 499.157526532378 0.87808450745098 -0.187568302491764 0.290832353711492 1 13.0169 10.6764 11.5952 11.7337 GeneID:25972,Genbank:NM_001330354.1,HGNC:HGNC:16046,MIM:617826 unc-50 inner nuclear membrane RNA binding protein GO:0003723,GO:0005637,GO:0015031,GO:0030173 RNA binding|nuclear inner membrane|protein transport|integral component of Golgi membrane UNC5A 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0064351 0 GeneID:90249,Genbank:NM_133369.2,HGNC:HGNC:12567,MIM:607869 unc-5 netrin receptor A GO:0005886,GO:0006915,GO:0007411,GO:0016021,GO:0031175,GO:0031226,GO:0032589,GO:0032809,GO:0033564,GO:0038007,GO:0045121 plasma membrane|apoptotic process|axon guidance|integral component of membrane|neuron projection development|intrinsic component of plasma membrane|neuron projection membrane|neuronal cell body membrane|anterior/posterior axon guidance|netrin-activated signaling pathway|membrane raft hsa04360 Axon guidance UNC5B 149.316844205304 121.285733655184 177.347954755424 1.46223260898619 0.548172830536203 0.0779693670199545 0.94157495521624 0.638321 0.685271 0.806771 1.0791 GeneID:219699,Genbank:NM_170744.4,HGNC:HGNC:12568,MIM:607870 unc-5 netrin receptor B GO:0001525,GO:0005886,GO:0006915,GO:0007165,GO:0014068,GO:0016021,GO:0033564,GO:0043524,GO:0045121,GO:2001240 angiogenesis|plasma membrane|apoptotic process|signal transduction|positive regulation of phosphatidylinositol 3-kinase signaling|integral component of membrane|anterior/posterior axon guidance|negative regulation of neuron apoptotic process|membrane raft|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand hsa04360 Axon guidance UNC5C 798.061492114524 745.950871006293 850.172113222756 1.13971596021581 0.188674321015615 0.474119462748374 1 1.77062 1.64116 2.33251 1.57747 GeneID:8633,Genbank:NM_003728.3,HGNC:HGNC:12569,MIM:603610 unc-5 netrin receptor C GO:0005042,GO:0005886,GO:0006915,GO:0007411,GO:0007420,GO:0016021,GO:0030054,GO:0030334,GO:0033564,GO:0043005,GO:0043065,GO:0045202 netrin receptor activity|plasma membrane|apoptotic process|axon guidance|brain development|integral component of membrane|cell junction|regulation of cell migration|anterior/posterior axon guidance|neuron projection|positive regulation of apoptotic process|synapse hsa04360 Axon guidance UNC5CL 14.652381568078 12.8281003451534 16.4766627910026 1.28441954363319 0.361116522284831 0.65979182994785 1 0.211978 0.077623 0.180759 0.153426 GeneID:222643,Genbank:NM_173561.2,HGNC:HGNC:21203,MIM:617464 unc-5 family C-terminal like GO:0005737,GO:0007165,GO:0008233,GO:0016020,GO:0016021,GO:0043123,GO:0046330 cytoplasm|signal transduction|peptidase activity|membrane|integral component of membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of JNK cascade UNC5D 169.691392179637 161.970451671898 177.412332687375 1.09533764249024 0.131375655270177 0.719399986489377 1 0.497124 0.517612 0.716889 0.40691 GeneID:137970,Genbank:NM_080872.3,HGNC:HGNC:18634,MIM:616466 unc-5 netrin receptor D GO:0005886,GO:0006915,GO:0007165,GO:0007411,GO:0009986,GO:0016021,GO:0021859,GO:0098742,GO:2001222 plasma membrane|apoptotic process|signal transduction|axon guidance|cell surface|integral component of membrane|pyramidal neuron differentiation|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of neuron migration hsa04360 Axon guidance UNC79 3.40504933082388 1.96028560782945 4.8498130538183 2.47403390324756 1.30686527061015 0.625313103834389 1 0 0.00427663 0.00217151 0 GeneID:57578,Genbank:NM_020818.4,HGNC:HGNC:19966,MIM:616884 unc-79 homolog, NALCN channel complex subunit GO:0005886,GO:0016021,GO:0034220,GO:0035264,GO:0048149 plasma membrane|integral component of membrane|ion transmembrane transport|multicellular organism growth|behavioral response to ethanol UNC80 21.0048953580358 18.2571033862613 23.7526873298102 1.30101072592295 0.379632856115707 0.559170181401942 1 0.0477724 0.0201135 0.0455565 0.0275958 GeneID:285175,Genbank:XM_017003891.1,HGNC:HGNC:26582,MIM:612636 unc-80 homolog, NALCN channel complex subunit GO:0005886,GO:0016021,GO:0034220 plasma membrane|integral component of membrane|ion transmembrane transport UNC93B1 241.683717734415 253.660813111755 229.706622357076 0.905566057047506 -0.143108211636928 0.527469543958548 1 3.76427 5.10091 4.28885 4.2337 GeneID:81622,Genbank:NM_030930.3,HGNC:HGNC:13481,MIM:608204 unc-93 homolog B1, TLR signaling regulator UNG 1790.09152039628 1811.89569917796 1768.28734161459 0.975932192132717 -0.0351471822142286 0.798281364207135 1 33.5559 35.3604 33.0138 36.2354 GeneID:7374,Genbank:NM_080911.2,HGNC:HGNC:12572,MIM:191525 uracil DNA glycosylase hsa03410,hsa05340 Base excision repair|Primary immunodeficiency UNK 1093.50931808071 1043.78473687826 1143.23389928316 1.09527746372527 0.131296390222147 0.384966747954297 1 4.62607 4.5799 5.21524 4.93654 GeneID:85451,Genbank:XM_017025248.1,HGNC:HGNC:29369,MIM:616375 unkempt family zinc finger GO:0001764,GO:0003723,GO:0005737,GO:0005844,GO:0046872,GO:0048667,GO:1990715,GO:2000766 neuron migration|RNA binding|cytoplasm|polysome|metal ion binding|cell morphogenesis involved in neuron differentiation|mRNA CDS binding|negative regulation of cytoplasmic translation UNKL 333.910041336362 335.846695814827 331.973386857896 0.98846703271106 -0.0167352448027778 0.92757274683567 1 2.5102 2.5536 2.62524 2.36539 GeneID:64718,Genbank:XM_005255505.1,HGNC:HGNC:14184,MIM:617463 unkempt family like zinc finger GO:0000209,GO:0004842,GO:0005634,GO:0005829,GO:0046872 protein polyubiquitination|ubiquitin-protein transferase activity|nucleus|cytosol|metal ion binding UPB1 4.70683536108819 5.53486424558581 3.87880647659057 0.700795232635382 -0.512935134270032 0.758093511601002 1 0.0354602 0.110866 0.0998057 0.015494 GeneID:51733,Genbank:XM_011530222.2,HGNC:HGNC:16297,MIM:606673 beta-ureidopropionase 1 GO:0003837,GO:0005829,GO:0019483,GO:0046135,GO:0046872,GO:0070062 beta-ureidopropionase activity|cytosol|beta-alanine biosynthetic process|pyrimidine nucleoside catabolic process|metal ion binding|extracellular exosome hsa00240,hsa00410,hsa00770,hsa00983 Pyrimidine metabolism|beta-Alanine metabolism|Pantothenate and CoA biosynthesis|Drug metabolism - other enzymes UPF1 4143.82834739088 4264.69856955824 4022.95812522351 0.943315936544663 -0.0841870538394472 0.515959152928849 1 30.2738 30.8709 30.1249 28.1375 GeneID:5976,Genbank:XM_017027105.2,HGNC:HGNC:9962,MIM:601430 UPF1, RNA helicase and ATPase GO:0000184,GO:0000294,GO:0000784,GO:0000785,GO:0000932,GO:0000956,GO:0003682,GO:0003723,GO:0004004,GO:0004386,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006260,GO:0006281,GO:0006406,GO:0006449,GO:0008270,GO:0009048,GO:0032201,GO:0032204,GO:0035145,GO:0042162,GO:0044530,GO:0044770,GO:0061014,GO:0061158,GO:0071044,GO:0071222,GO:0071347 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|nuclear chromosome, telomeric region|chromatin|P-body|nuclear-transcribed mRNA catabolic process|chromatin binding|RNA binding|ATP-dependent RNA helicase activity|helicase activity|ATP binding|nucleus|nucleoplasm|cytoplasm|cytosol|DNA replication|DNA repair|mRNA export from nucleus|regulation of translational termination|zinc ion binding|dosage compensation by inactivation of X chromosome|telomere maintenance via semi-conservative replication|regulation of telomere maintenance|exon-exon junction complex|telomeric DNA binding|supraspliceosomal complex|cell cycle phase transition|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|histone mRNA catabolic process|cellular response to lipopolysaccharide|cellular response to interleukin-1 hsa03013,hsa03015 RNA transport|mRNA surveillance pathway UPF2 200.966469963165 217.260242197108 184.672697729222 0.850006866703565 -0.234453598908593 0.540663896052395 1 1.03377 0.78726 0.876551 0.639848 GeneID:26019,Genbank:NM_080599.2,HGNC:HGNC:17854,MIM:605529 UPF2, regulator of nonsense mediated mRNA decay GO:0000184,GO:0001889,GO:0003723,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0006406,GO:0031100,GO:0035145,GO:0036464,GO:0042162,GO:0048471 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|liver development|RNA binding|nucleus|cytoplasm|cytosol|polysome|mRNA export from nucleus|animal organ regeneration|exon-exon junction complex|cytoplasmic ribonucleoprotein granule|telomeric DNA binding|perinuclear region of cytoplasm hsa03013,hsa03015 RNA transport|mRNA surveillance pathway UPF3A 691.249418642336 719.497840956558 663.000996328113 0.921477395188104 -0.11797931942749 0.472746324985484 1 3.06686 3.31477 3.03394 2.73949 GeneID:65110,Genbank:NM_023011.3,HGNC:HGNC:20332,MIM:605530 UPF3A, regulator of nonsense mediated mRNA decay GO:0000184,GO:0003723,GO:0005487,GO:0005634,GO:0005737,GO:0005829,GO:0042162,GO:0043231,GO:0045727,GO:0051028 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|RNA binding|nucleocytoplasmic transporter activity|nucleus|cytoplasm|cytosol|telomeric DNA binding|intracellular membrane-bounded organelle|positive regulation of translation|mRNA transport hsa03013,hsa03015 RNA transport|mRNA surveillance pathway UPF3B 298.88052311583 336.018166602496 261.742879629164 0.778954549617555 -0.360388942408235 0.37989272932931 1 2.86135 2.08845 2.46851 1.53716 GeneID:65109,Genbank:XM_017029738.1,HGNC:HGNC:20439,MIM:300298 UPF3B, regulator of nonsense mediated mRNA decay GO:0000184,GO:0000398,GO:0003723,GO:0003729,GO:0005487,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005815,GO:0005829,GO:0006369,GO:0006405,GO:0006406,GO:0031124,GO:0035145,GO:0045727 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA splicing, via spliceosome|RNA binding|mRNA binding|nucleocytoplasmic transporter activity|nucleus|nucleoplasm|nucleolus|cytoplasm|microtubule organizing center|cytosol|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|mRNA 3'-end processing|exon-exon junction complex|positive regulation of translation hsa03013,hsa03015 RNA transport|mRNA surveillance pathway UPK1A 1.74946347503013 1.07619535328461 2.42273159677566 2.25120057374467 1.17069460137475 0.729443551161772 1 0.0391638 0 0.0726168 0.06791 GeneID:11045,Genbank:NM_001281443.1,HGNC:HGNC:12577,MIM:611557 uroplakin 1A GO:0005783,GO:0005886,GO:0005887,GO:0007166,GO:0009986,GO:0016021,GO:0016324,GO:0030855,GO:0042803,GO:0051259,GO:0070062 endoplasmic reticulum|plasma membrane|integral component of plasma membrane|cell surface receptor signaling pathway|cell surface|integral component of membrane|apical plasma membrane|epithelial cell differentiation|protein homodimerization activity|protein oligomerization|extracellular exosome UPK2 2.26311302830327 2.10436443188427 2.42186162472226 1.15087557460458 0.20273186682878 1 1 0.13086 0.0571788 0 0.170354 GeneID:7379,Genbank:NM_006760.3,HGNC:HGNC:12579,MIM:611558 uroplakin 2 GO:0005887,GO:0007275,GO:0016324,GO:0030855,GO:0070062 integral component of plasma membrane|multicellular organism development|apical plasma membrane|epithelial cell differentiation|extracellular exosome UPK3B 1.48171959478908 0.538097676642304 2.42534151293585 4.50725141217823 2.17224792508914 0.604228439629313 1 0 0 0.101021 0 GeneID:105375355,Genbank:NM_001347684.1,HGNC:HGNC:21444,MIM:611887 uroplakin 3B GO:0005886,GO:0016021 plasma membrane|integral component of membrane UPK3BL1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 1.32079 2.04905 2.62868 3.17434 GeneID:100134938,Genbank:NM_001114403.2,HGNC:HGNC:37278 uroplakin 3B like 1 GO:0016021 integral component of membrane UPK3BL2 2.22346137472701 3.47852608838648 0.968396661067546 0.278392812490516 -1.84480613053314 0.455030756033866 1 0.650683 0.614825 0.685935 1.88527 GeneID:107983993,Genbank:XM_017012896.2,HGNC:HGNC:53444 uroplakin 3B like 2 GO:0016021 integral component of membrane UPP1 2444.35845837583 2296.62601463675 2592.09090211491 1.12865172021701 0.174600367392872 0.253291988270293 1 37.6132 41.4959 43.6874 49.4064 GeneID:7378,Genbank:XM_024446913.1,HGNC:HGNC:12576,MIM:191730 uridine phosphorylase 1 GO:0004850,GO:0005634,GO:0005654,GO:0005829,GO:0006139,GO:0006218,GO:0009166,GO:0042149,GO:0043097,GO:0044206,GO:0046135 uridine phosphorylase activity|nucleus|nucleoplasm|cytosol|nucleobase-containing compound metabolic process|uridine catabolic process|nucleotide catabolic process|cellular response to glucose starvation|pyrimidine nucleoside salvage|UMP salvage|pyrimidine nucleoside catabolic process hsa00240,hsa00983 Pyrimidine metabolism|Drug metabolism - other enzymes UPP2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:151531,Genbank:NM_001135098.1,HGNC:HGNC:23061,MIM:617340 uridine phosphorylase 2 GO:0004850,GO:0005829,GO:0009116,GO:0009166,GO:0042802,GO:0043097,GO:0044206,GO:0045098,GO:0046108,GO:0046135 uridine phosphorylase activity|cytosol|nucleoside metabolic process|nucleotide catabolic process|identical protein binding|pyrimidine nucleoside salvage|UMP salvage|type III intermediate filament|uridine metabolic process|pyrimidine nucleoside catabolic process hsa00240,hsa00983 Pyrimidine metabolism|Drug metabolism - other enzymes UPRT 415.67674296042 397.151613332473 434.201872588367 1.09328996285577 0.128676083987479 0.462919051219177 1 3.71452 3.27339 3.67056 4.01933 GeneID:139596,Genbank:XM_024452338.1,HGNC:HGNC:28334,MIM:300656 uracil phosphoribosyltransferase homolog GO:0004849,GO:0005525,GO:0005634,GO:0005829,GO:0006206,GO:0007565,GO:0007595,GO:0032868,GO:0043097 uridine kinase activity|GTP binding|nucleus|cytosol|pyrimidine nucleobase metabolic process|female pregnancy|lactation|response to insulin|pyrimidine nucleoside salvage hsa00240 Pyrimidine metabolism UQCC1 1343.4206453716 1348.83438660978 1338.00690413343 0.991972711710322 -0.0116276609906222 0.935267688677962 1 13.7994 14.4386 13.9132 14.2521 GeneID:55245,Genbank:NM_001184977.1,HGNC:HGNC:15891,MIM:611797 ubiquinol-cytochrome c reductase complex assembly factor 1 GO:0005743,GO:0031410,GO:0034551,GO:0070131 mitochondrial inner membrane|cytoplasmic vesicle|mitochondrial respiratory chain complex III assembly|positive regulation of mitochondrial translation UQCC2 1766.48098884151 1820.99736740791 1711.96461027511 0.94012470359142 -0.0890759579691168 0.70855822041193 1 47.96 55.7132 43.7443 55.5813 GeneID:84300,Genbank:NM_032340.3,HGNC:HGNC:21237,MIM:614461 ubiquinol-cytochrome c reductase complex assembly factor 2 GO:0002082,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0016604,GO:0034551,GO:0042645,GO:0050796,GO:0070131,GO:1903364,GO:2001014 regulation of oxidative phosphorylation|mitochondrion|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nuclear body|mitochondrial respiratory chain complex III assembly|mitochondrial nucleoid|regulation of insulin secretion|positive regulation of mitochondrial translation|positive regulation of cellular protein catabolic process|regulation of skeletal muscle cell differentiation UQCC3 437.475322156213 397.652510390393 477.298133922033 1.20028950264503 0.263382417214817 0.326129311754422 1 8.6941 9.98629 9.87414 12.6132 GeneID:790955,Genbank:NM_001085372.2,HGNC:HGNC:34399,MIM:616097 ubiquinol-cytochrome c reductase complex assembly factor 3 GO:0006122,GO:0006754,GO:0031305,GO:0034551,GO:0042407,GO:0070300,GO:0097033,GO:1901612 mitochondrial electron transport, ubiquinol to cytochrome c|ATP biosynthetic process|integral component of mitochondrial inner membrane|mitochondrial respiratory chain complex III assembly|cristae formation|phosphatidic acid binding|mitochondrial respiratory chain complex III biogenesis|cardiolipin binding UQCR10 2442.81415873375 2517.3657999231 2368.2625175444 0.940770116769183 -0.0880858606841982 0.510358362755751 1 56.683 61.5552 54.1298 61.6939 GeneID:29796,Genbank:NM_001003684.1,HGNC:HGNC:30863,MIM:610843 ubiquinol-cytochrome c reductase, complex III subunit X GO:0005743,GO:0005750,GO:0006122,GO:0008121,GO:0009060,GO:0034551,GO:0070062 mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|aerobic respiration|mitochondrial respiratory chain complex III assembly|extracellular exosome hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease UQCR11 3435.65871271123 3604.43375865533 3266.88366676714 0.906351423138897 -0.141857554420274 0.594985627074953 1 94.4578 108.393 80.5343 106.49 GeneID:10975,Genbank:NM_006830.3,HGNC:HGNC:30862,MIM:609711 ubiquinol-cytochrome c reductase, complex III subunit XI GO:0005743,GO:0006091,GO:0006122,GO:0008121,GO:0009055,GO:0016021,GO:0070469 mitochondrial inner membrane|generation of precursor metabolites and energy|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|electron transfer activity|integral component of membrane|respiratory chain hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease UQCRB 3487.6907339938 3600.07179795981 3375.30967002778 0.937567320724156 -0.0930058099510495 0.506077121426681 1 9.46785 9.30461 9.5526 9.03021 GeneID:7381,Genbank:NM_006294.4,HGNC:HGNC:12582,MIM:191330 ubiquinol-cytochrome c reductase binding protein GO:0005743,GO:0005746,GO:0005750,GO:0006119,GO:0006122,GO:0009060,GO:0034551,GO:0055114 mitochondrial inner membrane|mitochondrial respiratory chain|mitochondrial respiratory chain complex III|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|aerobic respiration|mitochondrial respiratory chain complex III assembly|oxidation-reduction process hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease UQCRC1 10607.1308944505 10441.4016744627 10772.8601144382 1.03174463068366 0.0450859304154913 0.747114027430015 1 249.071 257.92 262.096 269.326 GeneID:7384,Genbank:NM_003365.2,HGNC:HGNC:12585,MIM:191328 ubiquinol-cytochrome c reductase core protein 1 GO:0004222,GO:0005739,GO:0005743,GO:0005746,GO:0005750,GO:0005829,GO:0006119,GO:0006122,GO:0008121,GO:0008270,GO:0009060,GO:0014823,GO:0016485,GO:0031625,GO:0032403,GO:0043209,GO:0043279,GO:0055114 metalloendopeptidase activity|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain|mitochondrial respiratory chain complex III|cytosol|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|zinc ion binding|aerobic respiration|response to activity|protein processing|ubiquitin protein ligase binding|protein complex binding|myelin sheath|response to alkaloid|oxidation-reduction process hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease UQCRC2 2602.18334940465 2564.63992622676 2639.72677258254 1.02927773430801 0.0416323231887431 0.760569553996275 1 47.2995 47.9573 49.6349 48.9565 GeneID:7385,Genbank:NM_003366.3,HGNC:HGNC:12586,MIM:191329 ubiquinol-cytochrome c reductase core protein 2 GO:0004222,GO:0005654,GO:0005739,GO:0005743,GO:0005750,GO:0005751,GO:0006119,GO:0006122,GO:0006627,GO:0008270,GO:0009060,GO:0032403,GO:0043209,GO:0070062 metalloendopeptidase activity|nucleoplasm|mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial respiratory chain complex IV|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|protein processing involved in protein targeting to mitochondrion|zinc ion binding|aerobic respiration|protein complex binding|myelin sheath|extracellular exosome hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease UQCRFS1 3153.21038863834 3208.74727452445 3097.67350275223 0.965384069772624 -0.0508250744541906 0.698284007951626 1 132.554 140.874 133.976 134.655 GeneID:7386,Genbank:NM_006003.2,HGNC:HGNC:12587,MIM:191327 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 GO:0005739,GO:0005743,GO:0005750,GO:0005751,GO:0006122,GO:0008121,GO:0009725,GO:0016021,GO:0032403,GO:0042493,GO:0046677,GO:0046872,GO:0051537 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial respiratory chain complex IV|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|response to hormone|integral component of membrane|protein complex binding|response to drug|response to antibiotic|metal ion binding|2 iron, 2 sulfur cluster binding hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease UQCRH 4634.68252190713 4578.48427763158 4690.88076618267 1.02454884231015 0.0349887621715323 0.839156134015858 1 107.473 114.117 114.383 121.836 GeneID:7388,Genbank:NM_001297565.1,HGNC:HGNC:12590,MIM:613844 ubiquinol-cytochrome c reductase hinge protein GO:0005739,GO:0005743,GO:0005746,GO:0005750,GO:0006119,GO:0006122,GO:0008121,GO:0009060,GO:0055114 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain|mitochondrial respiratory chain complex III|oxidative phosphorylation|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|aerobic respiration|oxidation-reduction process hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease UQCRHL 262.961826952548 237.132655614151 288.790998290944 1.21784575617813 0.284331423155452 0.3695632271293 1 19.1925 20.1869 20.8584 26.8946 GeneID:440567,Genbank:NM_001089591.1,HGNC:HGNC:51714 ubiquinol-cytochrome c reductase hinge protein like GO:0005750,GO:0006122,GO:0008121,GO:0009060 mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|aerobic respiration hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease UQCRQ 2799.06073519281 2859.43157048592 2738.6898998997 0.957774240225759 -0.0622424607316072 0.815771140679342 1 76.3744 91.694 68.3806 93.3939 GeneID:27089,Genbank:NM_014402.4,HGNC:HGNC:29594,MIM:612080 ubiquinol-cytochrome c reductase complex III subunit VII GO:0005739,GO:0005743,GO:0005750,GO:0006122,GO:0008121,GO:0021539,GO:0021548,GO:0021680,GO:0021766,GO:0021794,GO:0021854,GO:0021860,GO:0030901 mitochondrion|mitochondrial inner membrane|mitochondrial respiratory chain complex III|mitochondrial electron transport, ubiquinol to cytochrome c|ubiquinol-cytochrome-c reductase activity|subthalamus development|pons development|cerebellar Purkinje cell layer development|hippocampus development|thalamus development|hypothalamus development|pyramidal neuron development|midbrain development hsa00190,hsa04260,hsa04714,hsa04932,hsa05010,hsa05012,hsa05016 Oxidative phosphorylation|Cardiac muscle contraction|Thermogenesis|Non-alcoholic fatty liver disease (NAFLD)|Alzheimer disease|Parkinson disease|Huntington disease URB1 1248.14278671134 1235.26533387207 1261.02023955061 1.02084969518072 0.0297704666269458 0.8559316751448 1 4.22037 4.44951 4.73193 4.22925 GeneID:9875,Genbank:NM_014825.2,HGNC:HGNC:17344,MIM:608865 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) GO:0001650,GO:0003723,GO:0005730 fibrillar center|RNA binding|nucleolus URB2 1062.62608053865 1116.1986175075 1009.05354356979 0.904008953015031 -0.145591034186693 0.336374557386171 1 8.82541 8.84444 8.82444 7.44966 GeneID:9816,Genbank:NM_001314021.1,HGNC:HGNC:28967 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) GO:0005730,GO:0016235,GO:0030496,GO:0042254 nucleolus|aggresome|midbody|ribosome biogenesis URGCP 1094.68858071008 1021.92464588977 1167.45251553039 1.14240567562974 0.192075052006386 0.207511250212848 1 10.0871 10.5973 12.2369 12.0596 GeneID:55665,Genbank:NM_001077664.2,HGNC:HGNC:30890,MIM:610337 upregulator of cell proliferation GO:0005525,GO:0005634,GO:0005829,GO:0007049 GTP binding|nucleus|cytosol|cell cycle URI1 1190.5829630372 1230.11264582226 1151.05328025214 0.935729979007512 -0.0958358195105389 0.540223388326392 1 12.1249 10.9132 11.7868 10.047 GeneID:8725,Genbank:NM_001252641.1,HGNC:HGNC:13236,MIM:603494 URI1, prefoldin like chaperone GO:0000122,GO:0001106,GO:0001558,GO:0003682,GO:0004864,GO:0005634,GO:0005654,GO:0005665,GO:0005737,GO:0005739,GO:0005829,GO:0006351,GO:0006357,GO:0009615,GO:0010923,GO:0019212,GO:0030425,GO:0051219,GO:0071363,GO:0071383,GO:2001243 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription corepressor activity|regulation of cell growth|chromatin binding|protein phosphatase inhibitor activity|nucleus|nucleoplasm|DNA-directed RNA polymerase II, core complex|cytoplasm|mitochondrion|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|response to virus|negative regulation of phosphatase activity|phosphatase inhibitor activity|dendrite|phosphoprotein binding|cellular response to growth factor stimulus|cellular response to steroid hormone stimulus|negative regulation of intrinsic apoptotic signaling pathway URM1 1265.90928978187 1282.04364812209 1249.77493144166 0.974830251116886 -0.0367770731458306 0.812835614845401 1 8.50112 10.6177 8.7888 10.1008 GeneID:81605,Genbank:NM_001265582.1,HGNC:HGNC:28378,MIM:612693 ubiquitin related modifier 1 GO:0002098,GO:0005829,GO:0006400,GO:0034227,GO:0070062 tRNA wobble uridine modification|cytosol|tRNA modification|tRNA thio-modification|extracellular exosome hsa04122 Sulfur relay system UROD 2299.79881734763 2320.12001596538 2279.47761872988 0.982482631520858 -0.0254961914756182 0.873677765198219 1 46.019 48.9189 44.3912 52.3845 GeneID:7389,Genbank:NM_000374.4,HGNC:HGNC:12591,MIM:613521 uroporphyrinogen decarboxylase hsa00860 Porphyrin and chlorophyll metabolism UROS 1189.69231136274 1174.6131668898 1204.77145583568 1.02567508163196 0.0365737793288222 0.825792744485697 1 4.87305 5.20867 5.47822 5.16443 GeneID:7390,Genbank:XM_011540127.2,HGNC:HGNC:12592,MIM:606938 uroporphyrinogen III synthase GO:0004852,GO:0005739,GO:0005829,GO:0006780,GO:0006782,GO:0006783,GO:0046677,GO:0048037,GO:0070541,GO:0071243,GO:0071418 uroporphyrinogen-III synthase activity|mitochondrion|cytosol|uroporphyrinogen III biosynthetic process|protoporphyrinogen IX biosynthetic process|heme biosynthetic process|response to antibiotic|cofactor binding|response to platinum ion|cellular response to arsenic-containing substance|cellular response to amine stimulus hsa00860 Porphyrin and chlorophyll metabolism USB1 2418.96626955467 2551.98634767184 2285.9461914375 0.895751732184208 -0.158829166597987 0.246076607279144 1 19.5569 20.1087 18.2729 18.3318 GeneID:79650,Genbank:NM_001330568.1,HGNC:HGNC:25792,MIM:613276 U6 snRNA biogenesis phosphodiesterase 1 GO:0000175,GO:0005634,GO:0006397,GO:0008380,GO:0034477,GO:0045171 3'-5'-exoribonuclease activity|nucleus|mRNA processing|RNA splicing|U6 snRNA 3'-end processing|intercellular bridge USE1 366.500614607102 358.418389269335 374.582839944868 1.04509938987362 0.0636401504012291 0.752453973606637 1 14.2118 14.6809 14.6174 17.2892 GeneID:55850,Genbank:XM_017026976.1,HGNC:HGNC:30882,MIM:610675 unconventional SNARE in the ER 1 GO:0005783,GO:0005789,GO:0006890,GO:0007041,GO:0015031,GO:0016021,GO:0030163,GO:0032940 endoplasmic reticulum|endoplasmic reticulum membrane|retrograde vesicle-mediated transport, Golgi to ER|lysosomal transport|protein transport|integral component of membrane|protein catabolic process|secretion by cell hsa04130 SNARE interactions in vesicular transport USF1 943.433737549786 964.156089390303 922.711385709269 0.957014528936656 -0.0633872677040101 0.652116943542257 1 11.9342 15.3443 13.1385 12.8166 GeneID:7391,Genbank:NM_207005.2,HGNC:HGNC:12593,MIM:191523 upstream transcription factor 1 USF2 3006.79812788134 2873.88275551525 3139.71350024744 1.09249881339871 0.127631712765031 0.415848340075424 1 15.8867 18.4958 18.4828 20.0995 GeneID:7392,Genbank:NM_003367.3,HGNC:HGNC:12594,MIM:600390 upstream transcription factor 2, c-fos interacting GO:0000430,GO:0000432,GO:0003700,GO:0003705,GO:0005634,GO:0005654,GO:0006366,GO:0007595,GO:0019086,GO:0042803,GO:0043231,GO:0043425,GO:0043565,GO:0045944,GO:0046982,GO:0055088 regulation of transcription from RNA polymerase II promoter by glucose|positive regulation of transcription from RNA polymerase II promoter by glucose|DNA binding transcription factor activity|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nucleus|nucleoplasm|transcription from RNA polymerase II promoter|lactation|late viral transcription|protein homodimerization activity|intracellular membrane-bounded organelle|bHLH transcription factor binding|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|lipid homeostasis USF3 116.404905660603 114.030715175193 118.779096146012 1.04164124519892 0.0588584802155125 0.930159273866584 1 0.270639 0.282914 0.42798 0.170964 GeneID:205717,Genbank:XM_017005872.1,HGNC:HGNC:30494,MIM:617568 upstream transcription factor family member 3 GO:0000139,GO:0003677,GO:0004571,GO:0005634,GO:0005783,GO:0006491,GO:0010719,GO:0046983 Golgi membrane|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|nucleus|endoplasmic reticulum|N-glycan processing|negative regulation of epithelial to mesenchymal transition|protein dimerization activity USH2A 1.23875045746879 0.538097676642304 1.93940323829528 3.60418437484629 1.84967281522267 0.680545261345893 1 0.00188581 0 0.00541625 0 GeneID:7399,Genbank:NM_206933.2,HGNC:HGNC:12601,MIM:608400 usherin GO:0001917,GO:0002142,GO:0005518,GO:0005604,GO:0005737,GO:0007601,GO:0007605,GO:0016021,GO:0016324,GO:0017022,GO:0032391,GO:0032421,GO:0035315,GO:0036064,GO:0042803,GO:0045184,GO:0045494,GO:0048496,GO:0050896,GO:0050953,GO:0060113,GO:0060171,GO:1990075,GO:1990696 photoreceptor inner segment|stereocilia ankle link complex|collagen binding|basement membrane|cytoplasm|visual perception|sensory perception of sound|integral component of membrane|apical plasma membrane|myosin binding|photoreceptor connecting cilium|stereocilium bundle|hair cell differentiation|ciliary basal body|protein homodimerization activity|establishment of protein localization|photoreceptor cell maintenance|maintenance of animal organ identity|response to stimulus|sensory perception of light stimulus|inner ear receptor cell differentiation|stereocilium membrane|periciliary membrane compartment|USH2 complex USHBP1 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0.0138264 0.0146856 0 GeneID:83878,Genbank:NM_001297703.1,HGNC:HGNC:24058,MIM:611810 USH1 protein network component harmonin binding protein 1 GO:0030165 PDZ domain binding USO1 616.409983336049 634.215608360869 598.604358311228 0.943849931190313 -0.0833706004890853 0.826589995846801 1 5.36784 4.19826 5.31796 3.61156 GeneID:8615,Genbank:NM_001290049.1,HGNC:HGNC:30904,MIM:603344 USO1 vesicle transport factor GO:0000139,GO:0001650,GO:0003723,GO:0005783,GO:0005794,GO:0005795,GO:0005829,GO:0006886,GO:0006888,GO:0007030,GO:0008565,GO:0012507,GO:0016020,GO:0030133,GO:0045056,GO:0045296,GO:0048208,GO:0048211,GO:0048280,GO:0048471,GO:0061025 Golgi membrane|fibrillar center|RNA binding|endoplasmic reticulum|Golgi apparatus|Golgi stack|cytosol|intracellular protein transport|ER to Golgi vesicle-mediated transport|Golgi organization|protein transporter activity|ER to Golgi transport vesicle membrane|membrane|transport vesicle|transcytosis|cadherin binding|COPII vesicle coating|Golgi vesicle docking|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|membrane fusion USP1 859.429131773736 936.114124272546 782.744139274926 0.836163154661507 -0.258143622132283 0.104137031597098 1 8.66475 8.21184 7.84882 6.20924 GeneID:7398,Genbank:NM_001017415.1,HGNC:HGNC:12607,MIM:603478 ubiquitin specific peptidase 1 GO:0001501,GO:0004197,GO:0004843,GO:0005634,GO:0005654,GO:0006282,GO:0006511,GO:0008233,GO:0009411,GO:0016579,GO:0035520,GO:0036297,GO:0036459,GO:0042769 skeletal system development|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|regulation of DNA repair|ubiquitin-dependent protein catabolic process|peptidase activity|response to UV|protein deubiquitination|monoubiquitinated protein deubiquitination|interstrand cross-link repair|thiol-dependent ubiquitinyl hydrolase activity|DNA damage response, detection of DNA damage hsa03460 Fanconi anemia pathway USP10 1839.90853578415 1966.60132371476 1713.21574785354 0.871155595795797 -0.198997675448974 0.158384313553681 1 14.8069 15.698 14.075 12.6022 GeneID:9100,Genbank:NM_001272075.1,HGNC:HGNC:12608,MIM:609818 ubiquitin specific peptidase 10 GO:0002039,GO:0003723,GO:0004197,GO:0004843,GO:0005634,GO:0005654,GO:0005737,GO:0005769,GO:0005829,GO:0006511,GO:0006914,GO:0006974,GO:0010506,GO:0016579,GO:0019985,GO:0030330,GO:0036459,GO:0043124,GO:0043234,GO:0044325,GO:0071347 p53 binding|RNA binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|cytoplasm|early endosome|cytosol|ubiquitin-dependent protein catabolic process|autophagy|cellular response to DNA damage stimulus|regulation of autophagy|protein deubiquitination|translesion synthesis|DNA damage response, signal transduction by p53 class mediator|thiol-dependent ubiquitinyl hydrolase activity|negative regulation of I-kappaB kinase/NF-kappaB signaling|protein complex|ion channel binding|cellular response to interleukin-1 USP11 1799.13336022025 1745.14114430814 1853.12557613235 1.06187719095181 0.0866169240988912 0.546412607517523 1 17.6283 17.6676 18.5649 19.6792 GeneID:8237,Genbank:NM_004651.3,HGNC:HGNC:12609,MIM:300050 ubiquitin specific peptidase 11 GO:0004197,GO:0004843,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006511,GO:0016579,GO:0036459 cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|chromosome|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity USP12 614.022861516226 698.799172214763 529.24655081769 0.757365738056479 -0.400937937269528 0.0173990593959491 0.545445222117836 6.68632 6.41128 5.69718 4.63357 GeneID:219333,Genbank:NM_182488.3,HGNC:HGNC:20485,MIM:603091 ubiquitin specific peptidase 12 GO:0004197,GO:0004843,GO:0005654,GO:0006511,GO:0016579,GO:0036459,GO:0046872 cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleoplasm|ubiquitin-dependent protein catabolic process|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|metal ion binding USP13 1343.52476950852 1362.91996175099 1324.12957726604 0.97153876561092 -0.04165653259312 0.793309858941111 1 6.3117 6.01387 6.59141 5.19651 GeneID:8975,Genbank:NM_003940.2,HGNC:HGNC:12611,MIM:603591 ubiquitin specific peptidase 13 GO:0004197,GO:0004843,GO:0005654,GO:0005829,GO:0006355,GO:0006511,GO:0006914,GO:0008270,GO:0008283,GO:0010506,GO:0016579,GO:0030318,GO:0031625,GO:0035523,GO:0036459,GO:0043130,GO:0044313,GO:0044389,GO:0050821,GO:0051087,GO:0070536,GO:0070628,GO:1904288,GO:1904294,GO:1904378,GO:1904454 cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleoplasm|cytosol|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|autophagy|zinc ion binding|cell proliferation|regulation of autophagy|protein deubiquitination|melanocyte differentiation|ubiquitin protein ligase binding|protein K29-linked deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|ubiquitin binding|protein K6-linked deubiquitination|ubiquitin-like protein ligase binding|protein stabilization|chaperone binding|protein K63-linked deubiquitination|proteasome binding|BAT3 complex binding|positive regulation of ERAD pathway|maintenance of unfolded protein involved in ERAD pathway|ubiquitin-specific protease activity involved in positive regulation of ERAD pathway USP14 2652.9240826781 2768.2272124446 2537.62095291159 0.916695328152143 -0.125485773934915 0.363060627519572 1 26.3296 27.3609 26.7137 22.9209 GeneID:9097,Genbank:NM_005151.3,HGNC:HGNC:12612,MIM:607274 ubiquitin specific peptidase 14 GO:0000502,GO:0004197,GO:0004843,GO:0004866,GO:0005634,GO:0005829,GO:0005886,GO:0006511,GO:0007268,GO:0008193,GO:0009986,GO:0016579,GO:0031410,GO:0036459,GO:0045087,GO:0045202,GO:0050920,GO:0061136,GO:0070062,GO:0070628,GO:1903070 proteasome complex|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|endopeptidase inhibitor activity|nucleus|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|chemical synaptic transmission|tRNA guanylyltransferase activity|cell surface|protein deubiquitination|cytoplasmic vesicle|thiol-dependent ubiquitinyl hydrolase activity|innate immune response|synapse|regulation of chemotaxis|regulation of proteasomal protein catabolic process|extracellular exosome|proteasome binding|negative regulation of ER-associated ubiquitin-dependent protein catabolic process USP15 184.152629589595 181.188080551858 187.117178627332 1.03272344437568 0.0464539629680903 0.913006662390116 1 0.524876 0.438689 0.71363 0.358105 GeneID:9958,Genbank:NM_001351165.1,HGNC:HGNC:12613,MIM:604731 ubiquitin specific peptidase 15 GO:0004197,GO:0004843,GO:0005160,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0006511,GO:0007179,GO:0016579,GO:0030509,GO:0035520,GO:0035616,GO:0042802,GO:0046332,GO:0060389,GO:0061649 cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|transforming growth factor beta receptor binding|nucleus|cytoplasm|mitochondrion|cytosol|ubiquitin-dependent protein catabolic process|transforming growth factor beta receptor signaling pathway|protein deubiquitination|BMP signaling pathway|monoubiquitinated protein deubiquitination|histone H2B conserved C-terminal lysine deubiquitination|identical protein binding|SMAD binding|pathway-restricted SMAD protein phosphorylation|ubiquitin modification-dependent histone binding hsa04137 Mitophagy - animal USP16 236.278183569254 264.133591995636 208.422775142872 0.789080910035535 -0.34175485735798 0.174848267147891 1 2.34138 1.91896 2.14348 1.32796 GeneID:10600,Genbank:NM_001032410.1,HGNC:HGNC:12614,MIM:604735 ubiquitin specific peptidase 16 GO:0000278,GO:0003713,GO:0004197,GO:0004843,GO:0005634,GO:0005654,GO:0005737,GO:0006351,GO:0006357,GO:0006511,GO:0006974,GO:0007049,GO:0008270,GO:0016578,GO:0016579,GO:0035522,GO:0036459,GO:0042393,GO:0043130,GO:0045893,GO:0045901,GO:0045944,GO:0051289,GO:0051301,GO:0051726,GO:0070537 mitotic cell cycle|transcription coactivator activity|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|cell cycle|zinc ion binding|histone deubiquitination|protein deubiquitination|monoubiquitinated histone H2A deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|histone binding|ubiquitin binding|positive regulation of transcription, DNA-templated|positive regulation of translational elongation|positive regulation of transcription from RNA polymerase II promoter|protein homotetramerization|cell division|regulation of cell cycle|histone H2A K63-linked deubiquitination USP18 462.613079734558 297.304559849574 627.921599619541 2.11204833164095 1.07864284938429 0.360544431241093 1 4.56571 5.21787 17.7302 4.6641 GeneID:11274,Genbank:XM_006724074.3,HGNC:HGNC:12616,MIM:607057 ubiquitin specific peptidase 18 GO:0004843,GO:0005634,GO:0005829,GO:0006511,GO:0016579,GO:0019785,GO:0036459,GO:0050727,GO:0060338 thiol-dependent ubiquitin-specific protease activity|nucleus|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination|ISG15-specific protease activity|thiol-dependent ubiquitinyl hydrolase activity|regulation of inflammatory response|regulation of type I interferon-mediated signaling pathway USP19 2424.4197984571 2440.74319043008 2408.09640648413 0.986624244585027 -0.0194273553830266 0.870664946637953 1 13.4264 14.4655 14.0703 13.4663 GeneID:10869,Genbank:NM_001351102.1,HGNC:HGNC:12617,MIM:614471 ubiquitin specific peptidase 19 GO:0004843,GO:0005634,GO:0005789,GO:0005829,GO:0016021,GO:0016579,GO:0030433,GO:0031625,GO:0031647,GO:0034976,GO:0036459,GO:0046872,GO:0048642,GO:0050821,GO:0051879,GO:0090068,GO:1900037,GO:1901799,GO:1904292,GO:1990380 thiol-dependent ubiquitin-specific protease activity|nucleus|endoplasmic reticulum membrane|cytosol|integral component of membrane|protein deubiquitination|ubiquitin-dependent ERAD pathway|ubiquitin protein ligase binding|regulation of protein stability|response to endoplasmic reticulum stress|thiol-dependent ubiquitinyl hydrolase activity|metal ion binding|negative regulation of skeletal muscle tissue development|protein stabilization|Hsp90 protein binding|positive regulation of cell cycle process|regulation of cellular response to hypoxia|negative regulation of proteasomal protein catabolic process|regulation of ERAD pathway|Lys48-specific deubiquitinase activity USP2 34.9521659185452 32.1133728100144 37.790959027076 1.17679819091725 0.234866933863162 0.681445547280338 1 0.3535 0.210142 0.243581 0.41613 GeneID:9099,Genbank:NM_001243759.1,HGNC:HGNC:12618,MIM:604725 ubiquitin specific peptidase 2 GO:0000122,GO:0004197,GO:0004843,GO:0005654,GO:0005813,GO:0005938,GO:0006511,GO:0007049,GO:0007517,GO:0016020,GO:0016579,GO:0030332,GO:0031625,GO:0032922,GO:0036459,GO:0042802,GO:0043153,GO:0045475,GO:0045931,GO:0046872,GO:0048471,GO:0048512,GO:0050821 negative regulation of transcription from RNA polymerase II promoter|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleoplasm|centrosome|cell cortex|ubiquitin-dependent protein catabolic process|cell cycle|muscle organ development|membrane|protein deubiquitination|cyclin binding|ubiquitin protein ligase binding|circadian regulation of gene expression|thiol-dependent ubiquitinyl hydrolase activity|identical protein binding|entrainment of circadian clock by photoperiod|locomotor rhythm|positive regulation of mitotic cell cycle|metal ion binding|perinuclear region of cytoplasm|circadian behavior|protein stabilization USP20 479.779671892795 455.556354059661 504.002989725929 1.10634608700886 0.145802759811402 0.414870132962639 1 2.98392 2.97708 3.37351 3.42575 GeneID:10868,Genbank:NM_001008563.4,HGNC:HGNC:12619,MIM:615143 ubiquitin specific peptidase 20 GO:0001664,GO:0004197,GO:0004843,GO:0005813,GO:0005829,GO:0006511,GO:0006897,GO:0008270,GO:0008277,GO:0016579,GO:0036459,GO:0048471,GO:0070536,GO:0071108 G-protein coupled receptor binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|centrosome|cytosol|ubiquitin-dependent protein catabolic process|endocytosis|zinc ion binding|regulation of G-protein coupled receptor protein signaling pathway|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|perinuclear region of cytoplasm|protein K63-linked deubiquitination|protein K48-linked deubiquitination USP21 558.120555500941 509.482808584332 606.75830241755 1.19092988456963 0.252088477718101 0.145292448514477 1 6.16601 6.6725 8.47044 7.6626 GeneID:27005,Genbank:NM_001319847.1,HGNC:HGNC:12620,MIM:604729 ubiquitin specific peptidase 21 GO:0003713,GO:0004843,GO:0005654,GO:0005829,GO:0005886,GO:0006351,GO:0006511,GO:0008234,GO:0016578,GO:0016579,GO:0019784,GO:0031175,GO:0036459,GO:0045893,GO:0046872 transcription coactivator activity|thiol-dependent ubiquitin-specific protease activity|nucleoplasm|cytosol|plasma membrane|transcription, DNA-templated|ubiquitin-dependent protein catabolic process|cysteine-type peptidase activity|histone deubiquitination|protein deubiquitination|NEDD8-specific protease activity|neuron projection development|thiol-dependent ubiquitinyl hydrolase activity|positive regulation of transcription, DNA-templated|metal ion binding hsa04217 Necroptosis USP22 12917.5385690288 12831.9231911714 13003.1539468862 1.01334412255777 0.0191241836165069 0.894037592780909 1 105.46 108.408 108.624 110.403 GeneID:23326,Genbank:NM_015276.1,HGNC:HGNC:12621,MIM:612116 ubiquitin specific peptidase 22 GO:0000124,GO:0003713,GO:0004843,GO:0005654,GO:0006351,GO:0006511,GO:0007049,GO:0008270,GO:0009790,GO:0016574,GO:0016578,GO:0016579,GO:0016607,GO:0019899,GO:0030374,GO:0036459,GO:0043967,GO:0045893,GO:0045931 SAGA complex|transcription coactivator activity|thiol-dependent ubiquitin-specific protease activity|nucleoplasm|transcription, DNA-templated|ubiquitin-dependent protein catabolic process|cell cycle|zinc ion binding|embryo development|histone ubiquitination|histone deubiquitination|protein deubiquitination|nuclear speck|enzyme binding|ligand-dependent nuclear receptor transcription coactivator activity|thiol-dependent ubiquitinyl hydrolase activity|histone H4 acetylation|positive regulation of transcription, DNA-templated|positive regulation of mitotic cell cycle USP24 695.624620089788 737.792144961541 653.457095218035 0.885692670599112 -0.175121914751623 0.700121447161425 1 2.48388 2.06834 2.67025 1.39203 GeneID:23358,Genbank:XM_017000832.1,HGNC:HGNC:12623,MIM:610569 ubiquitin specific peptidase 24 GO:0005654,GO:0006511,GO:0016579,GO:0036459 nucleoplasm|ubiquitin-dependent protein catabolic process|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity USP25 199.362251259743 199.012947465955 199.711555053531 1.00351036249888 0.00505551440711178 0.981946873561122 1 0.827534 0.7398 1.02216 0.526884 GeneID:29761,Genbank:NM_001283041.2,HGNC:HGNC:12624,MIM:604736 ubiquitin specific peptidase 25 GO:0004843,GO:0005634,GO:0005783,GO:0005829,GO:0006464,GO:0006508,GO:0006511,GO:0008233,GO:0016579,GO:0031625,GO:0036459,GO:0043130,GO:0051117,GO:0070536,GO:0071108,GO:1904293,GO:1904455 thiol-dependent ubiquitin-specific protease activity|nucleus|endoplasmic reticulum|cytosol|cellular protein modification process|proteolysis|ubiquitin-dependent protein catabolic process|peptidase activity|protein deubiquitination|ubiquitin protein ligase binding|thiol-dependent ubiquitinyl hydrolase activity|ubiquitin binding|ATPase binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|negative regulation of ERAD pathway|ubiquitin-specific protease activity involved in negative regulation of ERAD pathway hsa04657 IL-17 signaling pathway USP27X 44.012688534169 44.8934468804828 43.1319301878553 0.960762275676512 -0.057748590141583 0.937693920461797 1 0.577619 0.46541 0.502374 0.478649 GeneID:389856,Genbank:NM_001145073.2,HGNC:HGNC:13486,MIM:300975 ubiquitin specific peptidase 27, X-linked GO:0005634,GO:0006351,GO:0006355,GO:0006511,GO:0007049,GO:0008270,GO:0016569,GO:0016579,GO:0036459 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|cell cycle|zinc ion binding|covalent chromatin modification|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity USP28 650.784060057116 694.754139485265 606.813980628968 0.873422619804106 -0.195248200525964 0.242489473601986 1 3.61333 3.75667 3.73432 2.78046 GeneID:57646,Genbank:NM_001346268.1,HGNC:HGNC:12625,MIM:610748 ubiquitin specific peptidase 28 GO:0000077,GO:0004843,GO:0005654,GO:0006281,GO:0006511,GO:0006974,GO:0007265,GO:0008283,GO:0010212,GO:0016579,GO:0016604,GO:0031647,GO:0034644,GO:0036459,GO:0042771,GO:0043234 DNA damage checkpoint|thiol-dependent ubiquitin-specific protease activity|nucleoplasm|DNA repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|Ras protein signal transduction|cell proliferation|response to ionizing radiation|protein deubiquitination|nuclear body|regulation of protein stability|cellular response to UV|thiol-dependent ubiquitinyl hydrolase activity|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|protein complex USP3 838.496933912464 877.365424969165 799.628442855763 0.911397258313281 -0.133848064268916 0.393618024783243 1 4.19324 4.46521 3.99712 3.84554 GeneID:9960,Genbank:NM_006537.3,HGNC:HGNC:12626,MIM:604728 ubiquitin specific peptidase 3 GO:0000122,GO:0000278,GO:0000790,GO:0000978,GO:0004843,GO:0005634,GO:0005654,GO:0006281,GO:0006355,GO:0006511,GO:0008270,GO:0016578,GO:0016579,GO:0031647,GO:0036459,GO:0036464,GO:0042393,GO:0090543,GO:1990841 negative regulation of transcription from RNA polymerase II promoter|mitotic cell cycle|nuclear chromatin|RNA polymerase II proximal promoter sequence-specific DNA binding|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|DNA repair|regulation of transcription, DNA-templated|ubiquitin-dependent protein catabolic process|zinc ion binding|histone deubiquitination|protein deubiquitination|regulation of protein stability|thiol-dependent ubiquitinyl hydrolase activity|cytoplasmic ribonucleoprotein granule|histone binding|Flemming body|promoter-specific chromatin binding USP30 246.202302888002 236.526914352608 255.877691423395 1.08181215708052 0.113450015269265 0.588315401382841 1 1.67665 1.42703 1.71683 1.66222 GeneID:84749,Genbank:NM_001301175.1,HGNC:HGNC:20065,MIM:612492 ubiquitin specific peptidase 30 GO:0000422,GO:0004197,GO:0004843,GO:0005739,GO:0005741,GO:0006511,GO:0008053,GO:0016021,GO:0016579,GO:0035871,GO:0036459,GO:0044313,GO:1901525 autophagy of mitochondrion|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|mitochondrion|mitochondrial outer membrane|ubiquitin-dependent protein catabolic process|mitochondrial fusion|integral component of membrane|protein deubiquitination|protein K11-linked deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|protein K6-linked deubiquitination|negative regulation of mitophagy hsa04137 Mitophagy - animal USP31 493.370631670514 561.17840316157 425.562860179458 0.758337914969499 -0.399087239079527 0.0542623534340521 0.849526737634191 1.85556 1.77023 1.55853 1.15348 GeneID:57478,Genbank:NM_020718.3,HGNC:HGNC:20060 ubiquitin specific peptidase 31 GO:0004843,GO:0005634,GO:0006511,GO:0016579 thiol-dependent ubiquitin-specific protease activity|nucleus|ubiquitin-dependent protein catabolic process|protein deubiquitination USP32 1497.23389712065 1356.23144991211 1638.23634432918 1.20793272006437 0.272540101076397 0.184796806937628 1 5.70996 5.07689 7.33473 5.54462 GeneID:84669,Genbank:XM_011525372.1,HGNC:HGNC:19143,MIM:607740 ubiquitin specific peptidase 32 GO:0004843,GO:0005509,GO:0005794,GO:0005829,GO:0006511,GO:0016020,GO:0016579 thiol-dependent ubiquitin-specific protease activity|calcium ion binding|Golgi apparatus|cytosol|ubiquitin-dependent protein catabolic process|membrane|protein deubiquitination USP33 1002.76996507852 1034.731094923 970.808835234044 0.938223312315061 -0.0919967465332301 0.677833663144486 1 6.57102 5.70074 6.55231 4.92624 GeneID:23032,Genbank:NM_201624.2,HGNC:HGNC:20059,MIM:615146 ubiquitin specific peptidase 33 GO:0001664,GO:0004197,GO:0004843,GO:0005654,GO:0005737,GO:0005794,GO:0005813,GO:0005829,GO:0005925,GO:0006511,GO:0006897,GO:0007411,GO:0008270,GO:0008277,GO:0009267,GO:0010506,GO:0016477,GO:0016579,GO:0017160,GO:0030891,GO:0032091,GO:0032092,GO:0036459,GO:0044297,GO:0048471,GO:0050821,GO:0051298,GO:0070536,GO:0071108 G-protein coupled receptor binding|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleoplasm|cytoplasm|Golgi apparatus|centrosome|cytosol|focal adhesion|ubiquitin-dependent protein catabolic process|endocytosis|axon guidance|zinc ion binding|regulation of G-protein coupled receptor protein signaling pathway|cellular response to starvation|regulation of autophagy|cell migration|protein deubiquitination|Ral GTPase binding|VCB complex|negative regulation of protein binding|positive regulation of protein binding|thiol-dependent ubiquitinyl hydrolase activity|cell body|perinuclear region of cytoplasm|protein stabilization|centrosome duplication|protein K63-linked deubiquitination|protein K48-linked deubiquitination USP34 409.157930146775 426.622524033961 391.693336259589 0.918126245552869 -0.123235552021191 0.801196885086032 1 1.28823 1.14229 1.52686 0.73963 GeneID:9736,Genbank:NM_014709.3,HGNC:HGNC:20066,MIM:615295 ubiquitin specific peptidase 34 GO:0004197,GO:0004843,GO:0005829,GO:0006511,GO:0016055,GO:0016579,GO:0036459,GO:0071108,GO:0090263 cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|cytosol|ubiquitin-dependent protein catabolic process|Wnt signaling pathway|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|protein K48-linked deubiquitination|positive regulation of canonical Wnt signaling pathway USP35 196.619333325391 169.821402758324 223.417263892457 1.3156013333043 0.395722375394899 0.091867771931304 0.985009977016794 1.14612 1.50034 1.8637 1.68232 GeneID:57558,Genbank:NM_020798.3,HGNC:HGNC:20061 ubiquitin specific peptidase 35 GO:0004843,GO:0006511,GO:0016579 thiol-dependent ubiquitin-specific protease activity|ubiquitin-dependent protein catabolic process|protein deubiquitination USP36 1432.70744130874 1517.15716619776 1348.25771641971 0.888673729036697 -0.170274255021501 0.234727965922136 1 7.40397 7.68626 6.94566 6.51546 GeneID:57602,Genbank:XM_017024900.2,HGNC:HGNC:20062,MIM:612543 ubiquitin specific peptidase 36 GO:0003723,GO:0004843,GO:0005730,GO:0006511,GO:0016579,GO:0016607,GO:1903146,GO:1903955 RNA binding|thiol-dependent ubiquitin-specific protease activity|nucleolus|ubiquitin-dependent protein catabolic process|protein deubiquitination|nuclear speck|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion USP37 244.126581197525 253.640178800684 234.612983594365 0.9249835128792 -0.112500443960464 0.805664356902668 1 1.20533 0.974774 1.33088 0.745009 GeneID:57695,Genbank:NM_020935.2,HGNC:HGNC:20063 ubiquitin specific peptidase 37 GO:0000082,GO:0004197,GO:0004843,GO:0005634,GO:0005654,GO:0006275,GO:0006511,GO:0016579,GO:0019901,GO:0035871,GO:0036459,GO:0051301,GO:0071108 G1/S transition of mitotic cell cycle|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|regulation of DNA replication|ubiquitin-dependent protein catabolic process|protein deubiquitination|protein kinase binding|protein K11-linked deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|cell division|protein K48-linked deubiquitination USP38 337.812160564155 353.315761495914 322.308559632395 0.912239403834587 -0.132515606681417 0.494335001317011 1 1.73642 1.75638 1.76566 1.43224 GeneID:84640,Genbank:XM_011532360.3,HGNC:HGNC:20067 ubiquitin specific peptidase 38 GO:0004843,GO:0006511,GO:0016579 thiol-dependent ubiquitin-specific protease activity|ubiquitin-dependent protein catabolic process|protein deubiquitination USP39 1912.6405556979 1898.03056206116 1927.25054933464 1.01539489819476 0.022040916443114 0.876959523434299 1 23.3885 22.9583 23.2888 25.4498 GeneID:10713,Genbank:XM_006711922.2,HGNC:HGNC:20071,MIM:611594 ubiquitin specific peptidase 39 GO:0000245,GO:0000398,GO:0005654,GO:0005681,GO:0006397,GO:0007049,GO:0008270,GO:0008380,GO:0016579,GO:0036459,GO:0051301 spliceosomal complex assembly|mRNA splicing, via spliceosome|nucleoplasm|spliceosomal complex|mRNA processing|cell cycle|zinc ion binding|RNA splicing|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|cell division hsa03040 Spliceosome USP4 1392.35798389837 1323.07232471499 1461.64364308174 1.10473449998026 0.14369968944886 0.326927616408748 1 8.50717 8.69126 10.2697 9.48708 GeneID:7375,Genbank:NM_199443.2,HGNC:HGNC:12627,MIM:603486 ubiquitin specific peptidase 4 GO:0000244,GO:0004843,GO:0005634,GO:0005737,GO:0005764,GO:0005829,GO:0005886,GO:0006511,GO:0016579,GO:0031397,GO:0031647,GO:0031685,GO:0034394,GO:0036459,GO:0042802,GO:0046872 spliceosomal tri-snRNP complex assembly|thiol-dependent ubiquitin-specific protease activity|nucleus|cytoplasm|lysosome|cytosol|plasma membrane|ubiquitin-dependent protein catabolic process|protein deubiquitination|negative regulation of protein ubiquitination|regulation of protein stability|adenosine receptor binding|protein localization to cell surface|thiol-dependent ubiquitinyl hydrolase activity|identical protein binding|metal ion binding USP40 838.159234299635 809.745380154157 866.573088445113 1.07017972523676 0.0978531021724021 0.517988411572389 1 3.34234 2.99565 3.76655 3.28118 GeneID:55230,Genbank:NM_018218.2,HGNC:HGNC:20069,MIM:610570 ubiquitin specific peptidase 40 GO:0006511,GO:0016579,GO:0036459 ubiquitin-dependent protein catabolic process|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity USP41 0.998717855860305 1.02816907859967 0.969266633120943 0.942711323745559 -0.0851120372001571 1 1 0 0 0.0421972 0.0392762 GeneID:373856,Genbank:XM_017029164.1,HGNC:HGNC:20070 ubiquitin specific peptidase 41 GO:0006511,GO:0016579,GO:0036459 ubiquitin-dependent protein catabolic process|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity USP42 360.413736986122 357.341176915196 363.486297057048 1.01719678710106 0.0245988102780035 0.872466467853293 1 2.11989 1.63462 2.09883 1.87734 GeneID:84132,Genbank:XM_024446969.1,HGNC:HGNC:20068 ubiquitin specific peptidase 42 GO:0004843,GO:0005654,GO:0006511,GO:0007283,GO:0016579,GO:0030154,GO:0036459 thiol-dependent ubiquitin-specific protease activity|nucleoplasm|ubiquitin-dependent protein catabolic process|spermatogenesis|protein deubiquitination|cell differentiation|thiol-dependent ubiquitinyl hydrolase activity USP43 3.48328843382648 3.57457863775636 3.3919982298966 0.948922537070171 -0.0756377736536537 1 1 0.0146377 0.019761 0.0206228 0.0256878 GeneID:124739,Genbank:XM_011523641.1,HGNC:HGNC:20072 ubiquitin specific peptidase 43 GO:0004843,GO:0005634,GO:0005654,GO:0006511,GO:0016579,GO:0019785,GO:0019985 thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|ubiquitin-dependent protein catabolic process|protein deubiquitination|ISG15-specific protease activity|translesion synthesis USP45 109.156042764803 123.312645847059 94.9994396825466 0.770394950412235 -0.376329847883434 0.360469949958275 1 0.401312 0.233857 0.294592 0.21439 GeneID:85015,Genbank:NM_001346025.1,HGNC:HGNC:20080 ubiquitin specific peptidase 45 GO:0004843,GO:0005634,GO:0005654,GO:0005737,GO:0006281,GO:0006511,GO:0008270,GO:0016579,GO:0070911 thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|cytoplasm|DNA repair|ubiquitin-dependent protein catabolic process|zinc ion binding|protein deubiquitination|global genome nucleotide-excision repair USP46 422.024965692936 443.275143045403 400.774788340469 0.904121953663029 -0.145410709328472 0.444217268541977 1 2.14893 1.95239 1.85395 1.88345 GeneID:64854,Genbank:NM_001286767.1,HGNC:HGNC:20075,MIM:612849 ubiquitin specific peptidase 46 GO:0001662,GO:0004843,GO:0006511,GO:0008343,GO:0016579,GO:0032228,GO:0036459,GO:0046872,GO:0048149,GO:0060013 behavioral fear response|thiol-dependent ubiquitin-specific protease activity|ubiquitin-dependent protein catabolic process|adult feeding behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|thiol-dependent ubiquitinyl hydrolase activity|metal ion binding|behavioral response to ethanol|righting reflex USP47 269.044867950306 274.415282781633 263.674453118979 0.960859214713631 -0.0576030323728571 0.832486157561005 1 1.00294 0.952007 1.11371 0.807942 GeneID:55031,Genbank:NM_001330208.1,HGNC:HGNC:20076,MIM:614460 ubiquitin specific peptidase 47 GO:0004843,GO:0005654,GO:0005737,GO:0006284,GO:0006511,GO:0006974,GO:0010972,GO:0016579,GO:0019005,GO:0030307,GO:0034644,GO:0035520,GO:0036459,GO:0042493,GO:0043066,GO:0043154,GO:0045892,GO:0071987,GO:0090263,GO:0101005,GO:1902230 thiol-dependent ubiquitin-specific protease activity|nucleoplasm|cytoplasm|base-excision repair|ubiquitin-dependent protein catabolic process|cellular response to DNA damage stimulus|negative regulation of G2/M transition of mitotic cell cycle|protein deubiquitination|SCF ubiquitin ligase complex|positive regulation of cell growth|cellular response to UV|monoubiquitinated protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|response to drug|negative regulation of apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of transcription, DNA-templated|WD40-repeat domain binding|positive regulation of canonical Wnt signaling pathway|ubiquitinyl hydrolase activity|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage USP48 981.89730094198 1034.23223186679 929.562370017174 0.898794624046203 -0.15393659952517 0.327432335493315 1 5.15123 4.88218 4.879 4.26322 GeneID:84196,Genbank:NM_001350164.1,HGNC:HGNC:18533,MIM:617445 ubiquitin specific peptidase 48 GO:0004843,GO:0005654,GO:0005739,GO:0005829,GO:0006511,GO:0016579 thiol-dependent ubiquitin-specific protease activity|nucleoplasm|mitochondrion|cytosol|ubiquitin-dependent protein catabolic process|protein deubiquitination USP49 154.782329059675 149.622614073594 159.942044045757 1.06896972116185 0.0962209889346362 0.701066635727835 1 0.645327 0.612521 0.792236 0.583212 GeneID:25862,Genbank:NM_001286554.1,HGNC:HGNC:20078 ubiquitin specific peptidase 49 GO:0000398,GO:0004197,GO:0004843,GO:0005654,GO:0006511,GO:0008270,GO:0016579,GO:0035616,GO:0036459,GO:0042393 mRNA splicing, via spliceosome|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleoplasm|ubiquitin-dependent protein catabolic process|zinc ion binding|protein deubiquitination|histone H2B conserved C-terminal lysine deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|histone binding USP5 3407.4760102876 3222.53793436502 3592.41408621018 1.11477790467594 0.156756313070734 0.258676390120536 1 32.0559 34.3404 37.1624 38.3599 GeneID:8078,Genbank:NM_001098536.1,HGNC:HGNC:12628,MIM:601447 ubiquitin specific peptidase 5 GO:0004197,GO:0004843,GO:0005764,GO:0005829,GO:0006511,GO:0008270,GO:0016567,GO:0016579,GO:0032436,GO:0036459,GO:0043130,GO:0071108 cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|lysosome|cytosol|ubiquitin-dependent protein catabolic process|zinc ion binding|protein ubiquitination|protein deubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|thiol-dependent ubiquitinyl hydrolase activity|ubiquitin binding|protein K48-linked deubiquitination USP51 1.83031249419293 2.69048838321152 0.97013660517434 0.360580112974258 -1.47160826468559 0.720020310446899 1 0.0454279 0 0.0174488 0 GeneID:158880,Genbank:XM_017029301.1,HGNC:HGNC:23086 ubiquitin specific peptidase 51 GO:0003682,GO:0004843,GO:0005694,GO:0006281,GO:0006511,GO:0008270,GO:0010564,GO:0010569,GO:0016578,GO:0016579,GO:0042393,GO:2001020,GO:2001032 chromatin binding|thiol-dependent ubiquitin-specific protease activity|chromosome|DNA repair|ubiquitin-dependent protein catabolic process|zinc ion binding|regulation of cell cycle process|regulation of double-strand break repair via homologous recombination|histone deubiquitination|protein deubiquitination|histone binding|regulation of response to DNA damage stimulus|regulation of double-strand break repair via nonhomologous end joining USP53 106.92206062281 113.982688900508 99.8614323451124 0.876110515626441 -0.19081522701342 0.655176171193076 1 0.544821 0.589043 0.724589 0.328799 GeneID:54532,Genbank:XM_017008312.2,HGNC:HGNC:29255,MIM:617431 ubiquitin specific peptidase 53 GO:0001508,GO:0005923,GO:0007605,GO:0010996,GO:0016579,GO:0051402 action potential|bicellular tight junction|sensory perception of sound|response to auditory stimulus|protein deubiquitination|neuron apoptotic process USP54 632.088688726368 603.631301687374 660.546075765362 1.09428731399265 0.129991579128269 0.42239394055144 1 1.61167 1.4505 1.76222 1.71177 GeneID:159195,Genbank:XM_024447842.1,HGNC:HGNC:23513 ubiquitin specific peptidase 54 GO:0016579,GO:0036459 protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity USP6 1.7789146977695 2.10436443188427 1.45346496365472 0.690690710046484 -0.533888275697058 0.969271251083323 1 0.00616012 0.0028251 0.00292046 0.00544421 GeneID:9098,Genbank:NM_001304284.1,HGNC:HGNC:12629,MIM:604334 ubiquitin specific peptidase 6 USP6NL 339.931851319042 362.415395724148 317.448306913936 0.875923900196453 -0.191122560195901 0.325982331990911 1 1.20605 1.24774 1.24621 0.988602 GeneID:9712,Genbank:NM_014688.3,HGNC:HGNC:16858,MIM:605405 USP6 N-terminal like GO:0005096,GO:0005829,GO:0005886,GO:0006886,GO:0007030,GO:0012505,GO:0017137,GO:0019068,GO:0031338,GO:0031410,GO:0032588,GO:0035526,GO:0043547,GO:0048227,GO:0090630,GO:1903358 GTPase activator activity|cytosol|plasma membrane|intracellular protein transport|Golgi organization|endomembrane system|Rab GTPase binding|virion assembly|regulation of vesicle fusion|cytoplasmic vesicle|trans-Golgi network membrane|retrograde transport, plasma membrane to Golgi|positive regulation of GTPase activity|plasma membrane to endosome transport|activation of GTPase activity|regulation of Golgi organization USP7 1731.61501977776 1819.79365953822 1643.43638001731 0.903089408737878 -0.147059268690255 0.301857336314013 1 8.7144 9.15933 8.4583 7.62787 GeneID:7874,Genbank:NM_003470.2,HGNC:HGNC:12630,MIM:602519 ubiquitin specific peptidase 7 hsa04068,hsa05168,hsa05169,hsa05203 FoxO signaling pathway|Herpes simplex infection|Epstein-Barr virus infection|Viral carcinogenesis USP8 532.824833120725 532.004441762445 533.645224479004 1.00308415228851 0.00444264383302003 0.963775510845037 1 2.69985 2.12815 2.84975 2.02295 GeneID:9101,Genbank:XM_006720761.3,HGNC:HGNC:12631,MIM:603158 ubiquitin specific peptidase 8 GO:0000281,GO:0004197,GO:0004843,GO:0005634,GO:0005737,GO:0005769,GO:0005829,GO:0006511,GO:0007032,GO:0008283,GO:0014069,GO:0016579,GO:0017124,GO:0019897,GO:0030496,GO:0031313,GO:0043197,GO:0045296,GO:0070536,GO:0071108,GO:0071549,GO:0090263,GO:1990090 mitotic cytokinesis|cysteine-type endopeptidase activity|thiol-dependent ubiquitin-specific protease activity|nucleus|cytoplasm|early endosome|cytosol|ubiquitin-dependent protein catabolic process|endosome organization|cell proliferation|postsynaptic density|protein deubiquitination|SH3 domain binding|extrinsic component of plasma membrane|midbody|extrinsic component of endosome membrane|dendritic spine|cadherin binding|protein K63-linked deubiquitination|protein K48-linked deubiquitination|cellular response to dexamethasone stimulus|positive regulation of canonical Wnt signaling pathway|cellular response to nerve growth factor stimulus hsa04137,hsa04144,hsa04934 Mitophagy - animal|Endocytosis|Cushing syndrome USP9X 1170.71613208693 1152.26874515105 1189.16351902281 1.03201924379796 0.0454698725761309 0.920704270500687 1 3.79457 3.19005 5.01099 2.26987 GeneID:8239,Genbank:XM_005272675.4,HGNC:HGNC:12632,MIM:300072 ubiquitin specific peptidase 9, X-linked GO:0000122,GO:0001764,GO:0004197,GO:0005737,GO:0005829,GO:0006511,GO:0007049,GO:0007059,GO:0007179,GO:0007292,GO:0008234,GO:0016020,GO:0016567,GO:0016579,GO:0030426,GO:0030509,GO:0036459,GO:0044267,GO:0048675,GO:0051301,GO:0070410 negative regulation of transcription from RNA polymerase II promoter|neuron migration|cysteine-type endopeptidase activity|cytoplasm|cytosol|ubiquitin-dependent protein catabolic process|cell cycle|chromosome segregation|transforming growth factor beta receptor signaling pathway|female gamete generation|cysteine-type peptidase activity|membrane|protein ubiquitination|protein deubiquitination|growth cone|BMP signaling pathway|thiol-dependent ubiquitinyl hydrolase activity|cellular protein metabolic process|axon extension|cell division|co-SMAD binding USPL1 132.79657581398 137.640386363408 127.952765264552 0.929616434864702 -0.10529252024108 0.691790970024781 1 0.804239 1.03366 0.997614 0.775131 GeneID:10208,Genbank:NM_001321532.1,HGNC:HGNC:20294,MIM:617470 ubiquitin specific peptidase like 1 GO:0005615,GO:0008283,GO:0015030,GO:0016926,GO:0030576,GO:0032183,GO:0070140 extracellular space|cell proliferation|Cajal body|protein desumoylation|Cajal body organization|SUMO binding|SUMO-specific isopeptidase activity UST 991.560511235886 867.400300795747 1115.72072167603 1.28628122523415 0.363206099815973 0.0219139974874093 0.60098387629854 4.08141 4.18763 6.20916 4.96007 GeneID:10090,Genbank:XM_017010152.1,HGNC:HGNC:17223,MIM:610752 uronyl 2-sulfotransferase GO:0000139,GO:0006477,GO:0008146,GO:0016021,GO:0030010,GO:0030208,GO:0050770 Golgi membrane|protein sulfation|sulfotransferase activity|integral component of membrane|establishment of cell polarity|dermatan sulfate biosynthetic process|regulation of axonogenesis hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate UTP11 974.468761738571 1014.56274920445 934.374774272696 0.920963020774586 -0.118784865624146 0.450890897803583 1 20.3947 20.1749 19.6353 18.2734 GeneID:51118,Genbank:NM_016037.3,HGNC:HGNC:24329,MIM:609440 UTP11, small subunit processome component GO:0003723,GO:0005615,GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0007399,GO:0032040,GO:0042274,GO:0043065 RNA binding|extracellular space|nucleoplasm|nucleolus|cytoplasm|rRNA processing|nervous system development|small-subunit processome|ribosomal small subunit biogenesis|positive regulation of apoptotic process UTP14A 1272.18964679437 1415.74181195791 1128.63748163083 0.797205727836751 -0.326976019065649 0.0270369095672033 0.658377776156645 10.3813 10.3947 8.0887 8.84273 GeneID:10813,Genbank:NM_006649.3,HGNC:HGNC:10665,MIM:300508 UTP14A, small subunit processome component GO:0003723,GO:0005654,GO:0005730,GO:0005829,GO:0006364,GO:0030490,GO:0032040 RNA binding|nucleoplasm|nucleolus|cytosol|rRNA processing|maturation of SSU-rRNA|small-subunit processome hsa03008 Ribosome biogenesis in eukaryotes UTP14C 301.284527472655 312.265433591081 290.30362135423 0.929669409821355 -0.105210309420733 0.618550877682319 1 2.39228 2.26882 2.32679 2.01625 GeneID:9724,Genbank:NM_021645.5,HGNC:HGNC:20321,MIM:608969 UTP14C, small subunit processome component GO:0005730,GO:0005829,GO:0007275,GO:0007283,GO:0030154,GO:0030490,GO:0032040,GO:0051321 nucleolus|cytosol|multicellular organism development|spermatogenesis|cell differentiation|maturation of SSU-rRNA|small-subunit processome|meiotic cell cycle hsa03008 Ribosome biogenesis in eukaryotes UTP15 421.865016568173 465.712566330964 378.017466805381 0.811696943854289 -0.300986913300083 0.10149183049834 1 3.71977 3.59143 3.00543 2.94829 GeneID:84135,Genbank:NM_032175.3,HGNC:HGNC:25758,MIM:616194 UTP15, small subunit processome component GO:0001650,GO:0003723,GO:0005654,GO:0005730,GO:0005737,GO:0005783,GO:0006351,GO:0006364,GO:0045943,GO:2000234 fibrillar center|RNA binding|nucleoplasm|nucleolus|cytoplasm|endoplasmic reticulum|transcription, DNA-templated|rRNA processing|positive regulation of transcription from RNA polymerase I promoter|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes UTP18 1669.03810855316 1769.79758488431 1568.27863222201 0.886134462842834 -0.174402463649087 0.223167395005818 1 16.9686 17.894 16.5365 15.1943 GeneID:51096,Genbank:NM_016001.2,HGNC:HGNC:24274,MIM:612816 UTP18, small subunit processome component GO:0000462,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0031965,GO:0032040,GO:0034388 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleoplasm|nucleolus|rRNA processing|nuclear membrane|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome hsa03008 Ribosome biogenesis in eukaryotes UTP20 427.686230592615 478.732771774857 376.639689410372 0.786743067565681 -0.346035533702623 0.276499348919271 1 1.85907 1.73921 1.80195 1.02973 GeneID:27340,Genbank:NM_014503.2,HGNC:HGNC:17897,MIM:612822 UTP20, small subunit processome component GO:0000447,GO:0000462,GO:0000472,GO:0000480,GO:0003723,GO:0005654,GO:0005730,GO:0005737,GO:0005886,GO:0006364,GO:0008285,GO:0030686,GO:0030688,GO:0032040 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|nucleolus|cytoplasm|plasma membrane|rRNA processing|negative regulation of cell proliferation|90S preribosome|preribosome, small subunit precursor|small-subunit processome UTP23 229.181727256835 246.078402363223 212.285052150448 0.862672425177344 -0.213115253081151 0.335150293608108 1 2.94578 2.96076 2.83848 2.26322 GeneID:84294,Genbank:NM_032334.2,HGNC:HGNC:28224 UTP23, small subunit processome component GO:0000462,GO:0000480,GO:0003723,GO:0003730,GO:0005730,GO:0032040,GO:0048027,GO:0070181 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|mRNA 3'-UTR binding|nucleolus|small-subunit processome|mRNA 5'-UTR binding|small ribosomal subunit rRNA binding UTP3 869.321010419092 921.027772016345 817.614248821838 0.887719430036175 -0.171824320175704 0.284481115408181 1 15.572 14.0622 14.4946 12.1553 GeneID:57050,Genbank:NM_020368.2,HGNC:HGNC:24477,MIM:611614 UTP3, small subunit processome component GO:0000462,GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0007420,GO:0016569,GO:0032040 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleus|nucleoplasm|nucleolus|rRNA processing|brain development|covalent chromatin modification|small-subunit processome UTP4 2233.0679203145 2364.37727861814 2101.75856201086 0.888926898857376 -0.169863311369103 0.224888018451018 1 39.3001 39.2117 35.1135 36.2336 GeneID:84916,Genbank:NM_032830.2,HGNC:HGNC:1983,MIM:607456 UTP4, small subunit processome component GO:0001650,GO:0003723,GO:0005654,GO:0005694,GO:0005730,GO:0006351,GO:0006355,GO:0006364,GO:0030490,GO:0034455 fibrillar center|RNA binding|nucleoplasm|chromosome|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|rRNA processing|maturation of SSU-rRNA|t-UTP complex hsa03008 Ribosome biogenesis in eukaryotes UTP6 1190.91969963431 1280.28222526554 1101.55717400307 0.860401833489955 -0.216917495784167 0.149616318410854 1 18.0032 16.9197 15.4864 14.5949 GeneID:55813,Genbank:NM_018428.2,HGNC:HGNC:18279 UTP6, small subunit processome component GO:0000462,GO:0005654,GO:0005730,GO:0006364,GO:0030515,GO:0032040,GO:0034388 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nucleoplasm|nucleolus|rRNA processing|snoRNA binding|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome hsa03008 Ribosome biogenesis in eukaryotes UTRN 925.713004356418 883.350108995421 968.075899717414 1.09591416796036 0.13213481079208 0.775078461758886 1 1.66563 1.43097 2.32189 1.16063 GeneID:7402,Genbank:XM_011536106.2,HGNC:HGNC:12635,MIM:128240 utrophin UTS2 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0 0 0 0 GeneID:10911,Genbank:XM_017000119.1,HGNC:HGNC:12636,MIM:604097 urotensin 2 GO:0005102,GO:0005179,GO:0005576,GO:0005615,GO:0006936,GO:0007186,GO:0007268,GO:0008217,GO:0097746 receptor binding|hormone activity|extracellular region|extracellular space|muscle contraction|G-protein coupled receptor signaling pathway|chemical synaptic transmission|regulation of blood pressure|regulation of blood vessel diameter hsa04080 Neuroactive ligand-receptor interaction UTS2B 1.48835427179097 2.00831188251439 0.968396661067546 0.482194359102791 -1.05231332105607 0.812659389660536 1 0.0115982 0.0331843 0 0 GeneID:257313,Genbank:XM_011512631.2,HGNC:HGNC:30894 urotensin 2B GO:0001664,GO:0005179,GO:0005576,GO:0007186,GO:0008217,GO:0097746 G-protein coupled receptor binding|hormone activity|extracellular region|G-protein coupled receptor signaling pathway|regulation of blood pressure|regulation of blood vessel diameter UTS2R 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.144802 0 0 GeneID:2837,Genbank:NM_018949.2,HGNC:HGNC:4468,MIM:600896 urotensin 2 receptor GO:0001604,GO:0003105,GO:0004930,GO:0005769,GO:0005886,GO:0005887,GO:0007165,GO:0007186,GO:0007200,GO:0007204,GO:0007218,GO:0008015,GO:0010841,GO:0016020,GO:0030307,GO:0035811,GO:0035814,GO:0042493,GO:0045766,GO:0045776,GO:0045777,GO:0045907,GO:0046005,GO:0048146,GO:0055037 urotensin II receptor activity|negative regulation of glomerular filtration|G-protein coupled receptor activity|early endosome|plasma membrane|integral component of plasma membrane|signal transduction|G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of cytosolic calcium ion concentration|neuropeptide signaling pathway|blood circulation|positive regulation of circadian sleep/wake cycle, wakefulness|membrane|positive regulation of cell growth|negative regulation of urine volume|negative regulation of renal sodium excretion|response to drug|positive regulation of angiogenesis|negative regulation of blood pressure|positive regulation of blood pressure|positive regulation of vasoconstriction|positive regulation of circadian sleep/wake cycle, REM sleep|positive regulation of fibroblast proliferation|recycling endosome hsa04080 Neuroactive ligand-receptor interaction UTY 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00341125 0 GeneID:7404,Genbank:XM_011531452.3,HGNC:HGNC:12638,MIM:400009 ubiquitously transcribed tetratricopeptide repeat containing, Y-linked GO:0005654,GO:0010468,GO:0032452,GO:0046872,GO:0051213,GO:0071558 nucleoplasm|regulation of gene expression|histone demethylase activity|metal ion binding|dioxygenase activity|histone demethylase activity (H3-K27 specific) hsa05202 Transcriptional misregulation in cancer UVRAG 307.682143636498 319.760583444496 295.603703828499 0.924453228863369 -0.11332776411 0.584443378253734 1 0.972295 1.0218 0.870483 0.988585 GeneID:7405,Genbank:NM_003369.3,HGNC:HGNC:12640,MIM:602493 UV radiation resistance associated GO:0000149,GO:0000775,GO:0005737,GO:0005764,GO:0005769,GO:0005770,GO:0005783,GO:0005813,GO:0006281,GO:0006890,GO:0006914,GO:0007051,GO:0007059,GO:0007098,GO:0017124,GO:0030496,GO:0032465,GO:0032801,GO:0035493,GO:0043234,GO:0045335,GO:0046718,GO:0051684,GO:0060627,GO:0071900,GO:0071985,GO:0097680,GO:1901098 SNARE binding|chromosome, centromeric region|cytoplasm|lysosome|early endosome|late endosome|endoplasmic reticulum|centrosome|DNA repair|retrograde vesicle-mediated transport, Golgi to ER|autophagy|spindle organization|chromosome segregation|centrosome cycle|SH3 domain binding|midbody|regulation of cytokinesis|receptor catabolic process|SNARE complex assembly|protein complex|phagocytic vesicle|viral entry into host cell|maintenance of Golgi location|regulation of vesicle-mediated transport|regulation of protein serine/threonine kinase activity|multivesicular body sorting pathway|double-strand break repair via classical nonhomologous end joining|positive regulation of autophagosome maturation hsa04140 Autophagy - animal UVSSA 296.096245679308 310.12285153962 282.069639818995 0.909541616874239 -0.136788443723674 0.504002415043722 1 0.714861 0.69465 0.670168 0.605693 GeneID:57654,Genbank:XM_017008493.2,HGNC:HGNC:29304,MIM:614632 UV stimulated scaffold protein A GO:0000993,GO:0005654,GO:0005694,GO:0006283,GO:0009411,GO:0016567 RNA polymerase II core binding|nucleoplasm|chromosome|transcription-coupled nucleotide-excision repair|response to UV|protein ubiquitination UXS1 738.100893376709 767.168020114514 709.033766638904 0.924222266894113 -0.11368824672599 0.491035326344782 1 4.97119 4.55839 4.7974 4.34627 GeneID:80146,Genbank:NM_025076.4,HGNC:HGNC:17729,MIM:609749 UDP-glucuronate decarboxylase 1 GO:0005737,GO:0005739,GO:0016021,GO:0032580,GO:0033320,GO:0042803,GO:0048040,GO:0051262,GO:0070062,GO:0070403 cytoplasm|mitochondrion|integral component of membrane|Golgi cisterna membrane|UDP-D-xylose biosynthetic process|protein homodimerization activity|UDP-glucuronate decarboxylase activity|protein tetramerization|extracellular exosome|NAD+ binding hsa00520 Amino sugar and nucleotide sugar metabolism UXT 799.502665941159 780.063764044568 818.94156783775 1.04983926389761 0.0701684603400132 0.693659333639746 1 42.1094 37.7186 39.9774 45.5974 GeneID:8409,Genbank:NM_004182.3,HGNC:HGNC:12641,MIM:300234 ubiquitously expressed prefoldin like chaperone GO:0000122,GO:0000226,GO:0000922,GO:0001106,GO:0003682,GO:0005634,GO:0005654,GO:0005737,GO:0005813,GO:0005856,GO:0006351,GO:0006915,GO:0007098,GO:0008017,GO:0047497,GO:0048487,GO:0070317 negative regulation of transcription from RNA polymerase II promoter|microtubule cytoskeleton organization|spindle pole|RNA polymerase II transcription corepressor activity|chromatin binding|nucleus|nucleoplasm|cytoplasm|centrosome|cytoskeleton|transcription, DNA-templated|apoptotic process|centrosome cycle|microtubule binding|mitochondrion transport along microtubule|beta-tubulin binding|negative regulation of G0 to G1 transition VAC14 1525.00613399961 1446.35757859844 1603.65468940079 1.1087539576173 0.14893925413144 0.31230518494851 1 2.63914 2.76148 3.17016 2.95954 GeneID:55697,Genbank:NM_001351157.1,HGNC:HGNC:25507,MIM:604632 Vac14, PIKFYVE complex component GO:0000139,GO:0004872,GO:0005783,GO:0006661,GO:0007165,GO:0010008,GO:0016032,GO:0031901,GO:0031902,GO:0043550,GO:0070772 Golgi membrane|receptor activity|endoplasmic reticulum|phosphatidylinositol biosynthetic process|signal transduction|endosome membrane|viral process|early endosome membrane|late endosome membrane|regulation of lipid kinase activity|PAS complex hsa05166,hsa05203 Human T-cell leukemia virus 1 infection|Viral carcinogenesis VAMP1 137.530484266122 122.900026685111 152.160941847134 1.23808713432581 0.308112852384221 0.245431102951843 1 1.56495 1.61259 1.85122 2.15469 GeneID:6843,Genbank:NM_016830.3,HGNC:HGNC:12642,MIM:185880 vesicle associated membrane protein 1 GO:0005484,GO:0005741,GO:0006886,GO:0006887,GO:0006906,GO:0009986,GO:0016021,GO:0016192,GO:0019905,GO:0030054,GO:0030672,GO:0031201,GO:0035493,GO:0035579,GO:0043195,GO:0070821 SNAP receptor activity|mitochondrial outer membrane|intracellular protein transport|exocytosis|vesicle fusion|cell surface|integral component of membrane|vesicle-mediated transport|syntaxin binding|cell junction|synaptic vesicle membrane|SNARE complex|SNARE complex assembly|specific granule membrane|terminal bouton|tertiary granule membrane hsa04130 SNARE interactions in vesicular transport VAMP2 1104.61907288697 1075.72562189975 1133.51252387419 1.05371899748227 0.0754901848218691 0.623933806531332 1 18.7205 19.1879 20.2147 20.1599 GeneID:6844,Genbank:NM_014232.2,HGNC:HGNC:12643,MIM:185881 vesicle associated membrane protein 2 GO:0005484,GO:0005765,GO:0005901,GO:0006887,GO:0006906,GO:0007165,GO:0016021,GO:0017004,GO:0019905,GO:0030054,GO:0030672,GO:0031201,GO:0031580,GO:0031982,GO:0042311,GO:0043005,GO:1902259 SNAP receptor activity|lysosomal membrane|caveola|exocytosis|vesicle fusion|signal transduction|integral component of membrane|cytochrome complex assembly|syntaxin binding|cell junction|synaptic vesicle membrane|SNARE complex|membrane raft distribution|vesicle|vasodilation|neuron projection|regulation of delayed rectifier potassium channel activity hsa04130,hsa04721,hsa04911,hsa04962,hsa04970 SNARE interactions in vesicular transport|Synaptic vesicle cycle|Insulin secretion|Vasopressin-regulated water reabsorption|Salivary secretion VAMP3 2199.49869859836 2327.2191129645 2071.77828423223 0.890237740267233 -0.167737431951316 0.230870373229845 1 39.7582 41.1796 36.826 35.7006 GeneID:9341,Genbank:NM_004781.3,HGNC:HGNC:12644,MIM:603657 vesicle associated membrane protein 3 GO:0000149,GO:0001921,GO:0002479,GO:0005484,GO:0005622,GO:0005829,GO:0005886,GO:0006461,GO:0006887,GO:0006904,GO:0006906,GO:0009986,GO:0016021,GO:0016192,GO:0016324,GO:0017075,GO:0017156,GO:0030054,GO:0030133,GO:0030136,GO:0030141,GO:0030665,GO:0030670,GO:0031201,GO:0032588,GO:0034446,GO:0035493,GO:0042147,GO:0043001,GO:0043005,GO:0043231,GO:0045202,GO:0048471,GO:0055037,GO:0055038,GO:0061024,GO:0061025,GO:0071346,GO:1903531 SNARE binding|positive regulation of receptor recycling|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|SNAP receptor activity|intracellular|cytosol|plasma membrane|protein complex assembly|exocytosis|vesicle docking involved in exocytosis|vesicle fusion|cell surface|integral component of membrane|vesicle-mediated transport|apical plasma membrane|syntaxin-1 binding|calcium ion regulated exocytosis|cell junction|transport vesicle|clathrin-coated vesicle|secretory granule|clathrin-coated vesicle membrane|phagocytic vesicle membrane|SNARE complex|trans-Golgi network membrane|substrate adhesion-dependent cell spreading|SNARE complex assembly|retrograde transport, endosome to Golgi|Golgi to plasma membrane protein transport|neuron projection|intracellular membrane-bounded organelle|synapse|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|membrane organization|membrane fusion|cellular response to interferon-gamma|negative regulation of secretion by cell hsa04130,hsa04145 SNARE interactions in vesicular transport|Phagosome VAMP4 235.052631651692 250.085217473144 220.02004583024 0.879780292707098 -0.184784809997787 0.407787691670774 1 1.79591 1.69513 1.63498 1.54283 GeneID:8674,Genbank:NM_001185127.1,HGNC:HGNC:12645,MIM:606909 vesicle associated membrane protein 4 GO:0000139,GO:0000149,GO:0000226,GO:0005484,GO:0005764,GO:0005768,GO:0005794,GO:0005886,GO:0006887,GO:0008021,GO:0009986,GO:0030133,GO:0030285,GO:0030665,GO:0031201,GO:0032588,GO:0035493,GO:0061024,GO:0090161 Golgi membrane|SNARE binding|microtubule cytoskeleton organization|SNAP receptor activity|lysosome|endosome|Golgi apparatus|plasma membrane|exocytosis|synaptic vesicle|cell surface|transport vesicle|integral component of synaptic vesicle membrane|clathrin-coated vesicle membrane|SNARE complex|trans-Golgi network membrane|SNARE complex assembly|membrane organization|Golgi ribbon formation hsa04130 SNARE interactions in vesicular transport VAMP7 6.20832659942785 5.6309167949557 6.7857364039 1.2050855395304 0.269135555647228 0.891527464950341 1 0.0929741 0.0903445 0.143782 0.0669442 GeneID:6845,Genbank:NM_005638.5,HGNC:HGNC:11486,MIM:300053 vesicle associated membrane protein 7 GO:0000149,GO:0005484,GO:0005737,GO:0005765,GO:0005789,GO:0005802,GO:0005886,GO:0006888,GO:0006892,GO:0006897,GO:0006906,GO:0006911,GO:0008333,GO:0009986,GO:0016020,GO:0016192,GO:0017156,GO:0019905,GO:0030027,GO:0030054,GO:0030141,GO:0030285,GO:0030665,GO:0030667,GO:0030670,GO:0031091,GO:0031143,GO:0031201,GO:0031902,GO:0034197,GO:0035493,GO:0035577,GO:0043001,GO:0043005,GO:0043231,GO:0043308,GO:0043312,GO:0043320,GO:0045177,GO:0045335,GO:0047496,GO:0048280,GO:0048471,GO:0050775,GO:0061024,GO:0070062,GO:1900483,GO:1903595 SNARE binding|SNAP receptor activity|cytoplasm|lysosomal membrane|endoplasmic reticulum membrane|trans-Golgi network|plasma membrane|ER to Golgi vesicle-mediated transport|post-Golgi vesicle-mediated transport|endocytosis|vesicle fusion|phagocytosis, engulfment|endosome to lysosome transport|cell surface|membrane|vesicle-mediated transport|calcium ion regulated exocytosis|syntaxin binding|lamellipodium|cell junction|secretory granule|integral component of synaptic vesicle membrane|clathrin-coated vesicle membrane|secretory granule membrane|phagocytic vesicle membrane|platelet alpha granule|pseudopodium|SNARE complex|late endosome membrane|triglyceride transport|SNARE complex assembly|azurophil granule membrane|Golgi to plasma membrane protein transport|neuron projection|intracellular membrane-bounded organelle|eosinophil degranulation|neutrophil degranulation|natural killer cell degranulation|apical part of cell|phagocytic vesicle|vesicle transport along microtubule|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|positive regulation of dendrite morphogenesis|membrane organization|extracellular exosome|regulation of protein targeting to vacuolar membrane|positive regulation of histamine secretion by mast cell hsa04130 SNARE interactions in vesicular transport VAMP8 8.79939091153099 10.3297170606816 7.26906476238037 0.703704149850231 -0.506959074054841 0.651232949390204 1 0.151226 0.273933 0.236594 0.176898 GeneID:8673,Genbank:NM_003761.4,HGNC:HGNC:12647,MIM:603177 vesicle associated membrane protein 8 GO:0000149,GO:0002479,GO:0005484,GO:0005737,GO:0005765,GO:0005769,GO:0005829,GO:0005886,GO:0006892,GO:0006906,GO:0008021,GO:0015031,GO:0016020,GO:0016021,GO:0016240,GO:0019869,GO:0030665,GO:0030667,GO:0030670,GO:0031201,GO:0031901,GO:0031902,GO:0031982,GO:0035577,GO:0035579,GO:0043312,GO:0046718,GO:0048471,GO:0055037,GO:0055038,GO:0061024,GO:0070062,GO:0070254,GO:0070821,GO:0097352,GO:0098594,GO:1903076,GO:1903531,GO:1903595 SNARE binding|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|SNAP receptor activity|cytoplasm|lysosomal membrane|early endosome|cytosol|plasma membrane|post-Golgi vesicle-mediated transport|vesicle fusion|synaptic vesicle|protein transport|membrane|integral component of membrane|autophagosome membrane docking|chloride channel inhibitor activity|clathrin-coated vesicle membrane|secretory granule membrane|phagocytic vesicle membrane|SNARE complex|early endosome membrane|late endosome membrane|vesicle|azurophil granule membrane|specific granule membrane|neutrophil degranulation|viral entry into host cell|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|membrane organization|extracellular exosome|mucus secretion|tertiary granule membrane|autophagosome maturation|mucin granule|regulation of protein localization to plasma membrane|negative regulation of secretion by cell|positive regulation of histamine secretion by mast cell hsa04130,hsa04140,hsa04611 SNARE interactions in vesicular transport|Autophagy - animal|Platelet activation VANGL1 1921.95074688166 1655.68941746911 2188.21207629422 1.32163197590471 0.40232049722796 0.00427655332660437 0.25749352661239 8.22016 8.1236 11.9262 10.1016 GeneID:81839,Genbank:NM_138959.2,HGNC:HGNC:15512,MIM:610132 VANGL planar cell polarity protein 1 GO:0007275,GO:0016021,GO:0016328,GO:0043473,GO:0060071 multicellular organism development|integral component of membrane|lateral plasma membrane|pigmentation|Wnt signaling pathway, planar cell polarity pathway hsa04310 Wnt signaling pathway VANGL2 65.748581888804 68.9833808155475 62.5137829620605 0.90621512345436 -0.142074527286397 0.718820927966569 1 0.556329 0.487149 0.441499 0.442697 GeneID:57216,Genbank:NM_020335.2,HGNC:HGNC:15511,MIM:600533 VANGL planar cell polarity protein 2 GO:0001725,GO:0001736,GO:0001843,GO:0001942,GO:0001947,GO:0003149,GO:0003150,GO:0003402,GO:0005886,GO:0005911,GO:0007266,GO:0009952,GO:0015012,GO:0016021,GO:0016323,GO:0016324,GO:0016328,GO:0022007,GO:0030111,GO:0030134,GO:0032835,GO:0032956,GO:0035019,GO:0035787,GO:0036342,GO:0036514,GO:0036515,GO:0042060,GO:0043507,GO:0045176,GO:0045197,GO:0048103,GO:0048105,GO:0048546,GO:0060028,GO:0060122,GO:0060187,GO:0060488,GO:0060489,GO:0060490,GO:0060993,GO:0061346,GO:0090103,GO:0090177,GO:0090179,GO:1904938,GO:1905515 stress fiber|establishment of planar polarity|neural tube closure|hair follicle development|heart looping|membranous septum morphogenesis|muscular septum morphogenesis|planar cell polarity pathway involved in axis elongation|plasma membrane|cell-cell junction|Rho protein signal transduction|anterior/posterior pattern specification|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|basolateral plasma membrane|apical plasma membrane|lateral plasma membrane|convergent extension involved in neural plate elongation|regulation of Wnt signaling pathway|COPII-coated ER to Golgi transport vesicle|glomerulus development|regulation of actin cytoskeleton organization|somatic stem cell population maintenance|cell migration involved in kidney development|post-anal tail morphogenesis|dopaminergic neuron axon guidance|serotonergic neuron axon guidance|wound healing|positive regulation of JUN kinase activity|apical protein localization|establishment or maintenance of epithelial cell apical/basal polarity|somatic stem cell division|establishment of body hair planar orientation|digestive tract morphogenesis|convergent extension involved in axis elongation|inner ear receptor cell stereocilium organization|cell pole|orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis|planar dichotomous subdivision of terminal units involved in lung branching morphogenesis|lateral sprouting involved in lung morphogenesis|kidney morphogenesis|planar cell polarity pathway involved in heart morphogenesis|cochlea morphogenesis|establishment of planar polarity involved in neural tube closure|planar cell polarity pathway involved in neural tube closure|planar cell polarity pathway involved in axon guidance|non-motile cilium assembly hsa04310 Wnt signaling pathway VAPA 3761.28045938417 3873.37470177029 3649.18621699805 0.942120630707434 -0.0860162981266295 0.528054292193701 1 19.4154 19.8471 18.6776 18.3976 GeneID:9218,Genbank:NM_003574.5,HGNC:HGNC:12648,MIM:605703 VAMP associated protein A GO:0000139,GO:0004871,GO:0005783,GO:0005789,GO:0005886,GO:0005923,GO:0006888,GO:0008017,GO:0008219,GO:0015630,GO:0016021,GO:0019904,GO:0030148,GO:0031175,GO:0031965,GO:0031982,GO:0033149,GO:0035577,GO:0043123,GO:0043312,GO:0044791,GO:0044828,GO:0044829,GO:0045296,GO:0046982,GO:0061025,GO:0070972,GO:0090114 Golgi membrane|signal transducer activity|endoplasmic reticulum|endoplasmic reticulum membrane|plasma membrane|bicellular tight junction|ER to Golgi vesicle-mediated transport|microtubule binding|cell death|microtubule cytoskeleton|integral component of membrane|protein domain specific binding|sphingolipid biosynthetic process|neuron projection development|nuclear membrane|vesicle|FFAT motif binding|azurophil granule membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil degranulation|positive regulation by host of viral release from host cell|negative regulation by host of viral genome replication|positive regulation by host of viral genome replication|cadherin binding|protein heterodimerization activity|membrane fusion|protein localization to endoplasmic reticulum|COPII-coated vesicle budding hsa04979 Cholesterol metabolism VAPB 1934.98549148165 1944.0286132594 1925.9423697039 0.990696513707597 -0.0134849196401201 0.93187000893008 1 10.7886 10.7833 11.2439 10.3333 GeneID:9217,Genbank:NM_004738.4,HGNC:HGNC:12649,MIM:605704 VAMP associated protein B and C hsa04979 Cholesterol metabolism VARS 5769.42252107199 5907.0052226979 5631.83981944609 0.953417105135698 -0.068820586038326 0.584973644742374 1 47.4035 48.7651 47.2879 46.0205 GeneID:7407,Genbank:NM_006295.2,HGNC:HGNC:12651,MIM:192150 valyl-tRNA synthetase GO:0002161,GO:0004832,GO:0005524,GO:0005739,GO:0005829,GO:0006418,GO:0006438 aminoacyl-tRNA editing activity|valine-tRNA ligase activity|ATP binding|mitochondrion|cytosol|tRNA aminoacylation for protein translation|valyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis VARS2 843.522841317861 795.333429745255 891.712252890467 1.1211803999941 0.165018429113378 0.303734175842195 1 7.6852 7.88436 9.55811 9.32958 GeneID:57176,Genbank:NM_020442.5,HGNC:HGNC:21642,MIM:612802 valyl-tRNA synthetase 2, mitochondrial GO:0002161,GO:0004832,GO:0005524,GO:0005739,GO:0006438 aminoacyl-tRNA editing activity|valine-tRNA ligase activity|ATP binding|mitochondrion|valyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis VASH1 138.118562477893 145.875547647314 130.361577308473 0.893649274405132 -0.162219358954169 0.52112661603714 1 0.629777 0.755673 0.617313 0.601027 GeneID:22846,Genbank:NM_014909.4,HGNC:HGNC:19964,MIM:609011 vasohibin 1 GO:0001525,GO:0001937,GO:0005615,GO:0005737,GO:0005783,GO:0007050,GO:0009611,GO:0010596,GO:0016525,GO:0043537,GO:0045177,GO:0060716,GO:1901491,GO:2000772 angiogenesis|negative regulation of endothelial cell proliferation|extracellular space|cytoplasm|endoplasmic reticulum|cell cycle arrest|response to wounding|negative regulation of endothelial cell migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|apical part of cell|labyrinthine layer blood vessel development|negative regulation of lymphangiogenesis|regulation of cellular senescence VASH2 14.2279556550763 14.8844385023527 13.5714728078 0.911789370197259 -0.133227504782175 0.908696751420405 1 0.0587622 0.0641894 0.0607388 0.0304922 GeneID:79805,Genbank:XM_011509997.1,HGNC:HGNC:25723,MIM:610471 vasohibin 2 GO:0000768,GO:0001938,GO:0005576,GO:0005737,GO:0045026,GO:0045766,GO:0060716 syncytium formation by plasma membrane fusion|positive regulation of endothelial cell proliferation|extracellular region|cytoplasm|plasma membrane fusion|positive regulation of angiogenesis|labyrinthine layer blood vessel development VASN 71.3909389164994 80.7549031176322 62.0269747153666 0.76808927162001 -0.380654096130066 0.306300895631973 1 1.28536 1.79764 1.10591 1.2966 GeneID:114990,Genbank:NM_138440.2,HGNC:HGNC:18517,MIM:608843 vasorin GO:0005615,GO:0005739,GO:0005765,GO:0005886,GO:0009986,GO:0010719,GO:0016021,GO:0030512,GO:0045296,GO:0050431,GO:0070062,GO:0071456,GO:0071461 extracellular space|mitochondrion|lysosomal membrane|plasma membrane|cell surface|negative regulation of epithelial to mesenchymal transition|integral component of membrane|negative regulation of transforming growth factor beta receptor signaling pathway|cadherin binding|transforming growth factor beta binding|extracellular exosome|cellular response to hypoxia|cellular response to redox state VASP 2877.62390536997 2737.05678181978 3018.19102892016 1.10271407190663 0.141058756007985 0.307214661283426 1 44.0891 43.359 48.2697 48.9321 GeneID:7408,Genbank:NM_003370.3,HGNC:HGNC:12652,MIM:601703 vasodilator stimulated phosphoprotein GO:0001843,GO:0003779,GO:0005522,GO:0005829,GO:0005886,GO:0005923,GO:0005925,GO:0007411,GO:0008154,GO:0015629,GO:0017124,GO:0030838,GO:0031258,GO:0031527,GO:0034329,GO:0045296,GO:0051289,GO:0070062 neural tube closure|actin binding|profilin binding|cytosol|plasma membrane|bicellular tight junction|focal adhesion|axon guidance|actin polymerization or depolymerization|actin cytoskeleton|SH3 domain binding|positive regulation of actin filament polymerization|lamellipodium membrane|filopodium membrane|cell junction assembly|cadherin binding|protein homotetramerization|extracellular exosome hsa04015,hsa04022,hsa04510,hsa04530,hsa04611,hsa04666,hsa04670 Rap1 signaling pathway|cGMP-PKG signaling pathway|Focal adhesion|Tight junction|Platelet activation|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration VAT1 5100.74727976343 4563.56634516049 5637.92821436637 1.23542155146823 0.305003403300433 0.0217128345589666 0.600929980812952 72.6073 70.4619 87.7807 91.6986 GeneID:10493,Genbank:NM_006373.3,HGNC:HGNC:16919,MIM:604631 vesicle amine transport 1 GO:0005576,GO:0005741,GO:0008270,GO:0010637,GO:0016021,GO:0016491,GO:0035578,GO:0043312,GO:0070062 extracellular region|mitochondrial outer membrane|zinc ion binding|negative regulation of mitochondrial fusion|integral component of membrane|oxidoreductase activity|azurophil granule lumen|neutrophil degranulation|extracellular exosome VAT1L 861.573212675425 915.666412560138 807.480012790711 0.881849548825379 -0.181395554385989 0.272882888954658 1 8.86556 8.44543 9.06038 6.6053 GeneID:57687,Genbank:NM_020927.2,HGNC:HGNC:29315 vesicle amine transport 1 like GO:0008270,GO:0016491 zinc ion binding|oxidoreductase activity VAV2 2277.93227907589 2092.38597788353 2463.47858026824 1.17735379911123 0.235547920651113 0.0964878142180427 1 8.6617 10.1028 12.4134 10.4014 GeneID:7410,Genbank:XM_005272213.1,HGNC:HGNC:12658,MIM:600428 vav guanine nucleotide exchange factor 2 GO:0001525,GO:0001784,GO:0005085,GO:0005089,GO:0005154,GO:0005829,GO:0005886,GO:0007165,GO:0007186,GO:0007264,GO:0008361,GO:0016477,GO:0030032,GO:0030168,GO:0035023,GO:0038095,GO:0038096,GO:0043065,GO:0043087,GO:0043552,GO:0046872,GO:0048010,GO:0048013,GO:0051056 angiogenesis|phosphotyrosine residue binding|guanyl-nucleotide exchange factor activity|Rho guanyl-nucleotide exchange factor activity|epidermal growth factor receptor binding|cytosol|plasma membrane|signal transduction|G-protein coupled receptor signaling pathway|small GTPase mediated signal transduction|regulation of cell size|cell migration|lamellipodium assembly|platelet activation|regulation of Rho protein signal transduction|Fc-epsilon receptor signaling pathway|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of apoptotic process|regulation of GTPase activity|positive regulation of phosphatidylinositol 3-kinase activity|metal ion binding|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|regulation of small GTPase mediated signal transduction hsa04015,hsa04024,hsa04062,hsa04510,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04670,hsa04810,hsa05205 Rap1 signaling pathway|cAMP signaling pathway|Chemokine signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Proteoglycans in cancer VAV3 16.6963443643069 19.3431073946539 14.04958133396 0.726335280433952 -0.461292436802479 0.518312829384768 1 0.032969 0.0467113 0.0203353 0.0540569 GeneID:10451,Genbank:NM_006113.4,HGNC:HGNC:12659,MIM:605541 vav guanine nucleotide exchange factor 3 hsa04024,hsa04062,hsa04510,hsa04650,hsa04660,hsa04662,hsa04664,hsa04666,hsa04670,hsa04810 cAMP signaling pathway|Chemokine signaling pathway|Focal adhesion|Natural killer cell mediated cytotoxicity|T cell receptor signaling pathway|B cell receptor signaling pathway|Fc epsilon RI signaling pathway|Fc gamma R-mediated phagocytosis|Leukocyte transendothelial migration|Regulation of actin cytoskeleton VAX1 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0178419 0 GeneID:11023,Genbank:NM_199131.2,HGNC:HGNC:12660,MIM:604294 ventral anterior homeobox 1 GO:0001162,GO:0001227,GO:0001764,GO:0005634,GO:0006351,GO:0007406,GO:0007411,GO:0007420,GO:0031490,GO:0035914,GO:0043010,GO:0060021 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|neuron migration|nucleus|transcription, DNA-templated|negative regulation of neuroblast proliferation|axon guidance|brain development|chromatin DNA binding|skeletal muscle cell differentiation|camera-type eye development|palate development VAX2 36.7708967528586 39.6183313185376 33.9234621871796 0.856256713954701 -0.22388469963349 0.6295123393425 1 0.177606 0.350314 0.198727 0.245254 GeneID:25806,Genbank:XM_006711982.4,HGNC:HGNC:12661,MIM:604295 ventral anterior homeobox 2 GO:0001162,GO:0001227,GO:0003700,GO:0005634,GO:0005737,GO:0006351,GO:0007398,GO:0007409,GO:0007601,GO:0009950,GO:0016055,GO:0030900,GO:0031490,GO:0048048,GO:0060041 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|transcription, DNA-templated|ectoderm development|axonogenesis|visual perception|dorsal/ventral axis specification|Wnt signaling pathway|forebrain development|chromatin DNA binding|embryonic eye morphogenesis|retina development in camera-type eye VBP1 1470.59005324624 1570.18768781107 1370.99241868141 0.87313919815067 -0.195716424454003 0.181811641838228 1 32.8299 32.5563 29.1504 28.5655 GeneID:7411,Genbank:NM_001303544.1,HGNC:HGNC:12662,MIM:300133 VHL binding protein 1 GO:0005634,GO:0005829,GO:0006457,GO:0016272 nucleus|cytosol|protein folding|prefoldin complex VCAM1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0112165 0 GeneID:7412,Genbank:NM_001078.3,HGNC:HGNC:12663,MIM:192225 vascular cell adhesion molecule 1 hsa04064,hsa04514,hsa04668,hsa04670,hsa04933,hsa05143,hsa05144,hsa05166,hsa05418 NF-kappa B signaling pathway|Cell adhesion molecules (CAMs)|TNF signaling pathway|Leukocyte transendothelial migration|AGE-RAGE signaling pathway in diabetic complications|African trypanosomiasis|Malaria|Human T-cell leukemia virus 1 infection|Fluid shear stress and atherosclerosis VCAN 1409.42016581 1344.71764229196 1474.12268932805 1.09623213302647 0.132553329051617 0.755972982262236 1 3.51081 2.68134 4.50037 2.41748 GeneID:1462,Genbank:NM_004385.4,HGNC:HGNC:2464,MIM:118661 versican hsa04514 Cell adhesion molecules (CAMs) VCL 10880.7768876524 10900.8694467303 10860.6843285745 0.996313585961912 -0.0053281982690375 0.967128521269358 1 73.6756 73.4856 81.6633 67.6619 GeneID:7414,Genbank:NM_014000.2,HGNC:HGNC:12665,MIM:193065 vinculin GO:0002009,GO:0002102,GO:0002162,GO:0005198,GO:0005737,GO:0005886,GO:0005903,GO:0005911,GO:0005912,GO:0005913,GO:0005915,GO:0005916,GO:0005925,GO:0007155,GO:0015629,GO:0030032,GO:0030334,GO:0031625,GO:0034333,GO:0034394,GO:0042383,GO:0043034,GO:0043234,GO:0043297,GO:0045121,GO:0045294,GO:0045296,GO:0048675,GO:0051015,GO:0090136,GO:0090636,GO:0090637,GO:1990357 morphogenesis of an epithelium|podosome|dystroglycan binding|structural molecule activity|cytoplasm|plasma membrane|brush border|cell-cell junction|adherens junction|cell-cell adherens junction|zonula adherens|fascia adherens|focal adhesion|cell adhesion|actin cytoskeleton|lamellipodium assembly|regulation of cell migration|ubiquitin protein ligase binding|adherens junction assembly|protein localization to cell surface|sarcolemma|costamere|protein complex|apical junction assembly|membrane raft|alpha-catenin binding|cadherin binding|axon extension|actin filament binding|epithelial cell-cell adhesion|outer dense plaque of desmosome|inner dense plaque of desmosome|terminal web hsa04510,hsa04520,hsa04670,hsa04810,hsa05100,hsa05131,hsa05146 Focal adhesion|Adherens junction|Leukocyte transendothelial migration|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Amoebiasis VCP 17604.3374250449 17512.6264100548 17696.0484400349 1.01047370198423 0.0150317754429039 0.919262196967998 1 141.504 145.578 149.152 143.774 GeneID:7415,Genbank:NM_007126.4,HGNC:HGNC:12666,MIM:601023 valosin containing protein GO:0000502,GO:0003723,GO:0005524,GO:0005576,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005811,GO:0005829,GO:0006281,GO:0006302,GO:0006457,GO:0006479,GO:0006734,GO:0006888,GO:0006914,GO:0006919,GO:0006974,GO:0008289,GO:0010498,GO:0010918,GO:0016236,GO:0016567,GO:0016579,GO:0016887,GO:0018279,GO:0019079,GO:0019903,GO:0019904,GO:0019985,GO:0030433,GO:0030968,GO:0030970,GO:0031334,GO:0031593,GO:0031625,GO:0032436,GO:0032510,GO:0034098,GO:0034214,GO:0034774,GO:0035578,GO:0035800,GO:0035861,GO:0036435,GO:0036503,GO:0036513,GO:0042288,GO:0042802,GO:0042981,GO:0043161,GO:0043209,GO:0043231,GO:0043234,GO:0043312,GO:0043531,GO:0044389,GO:0045184,GO:0045732,GO:0046034,GO:0048471,GO:0051260,GO:0055085,GO:0061857,GO:0070062,GO:0070842,GO:0070987,GO:0071712,GO:0072389,GO:0097352,GO:1903006,GO:1903007,GO:1903715,GO:1903862,GO:1904288,GO:1904813,GO:1904949,GO:1990381,GO:1990730,GO:2001171 proteasome complex|RNA binding|ATP binding|extracellular region|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|lipid droplet|cytosol|DNA repair|double-strand break repair|protein folding|protein methylation|NADH metabolic process|ER to Golgi vesicle-mediated transport|autophagy|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to DNA damage stimulus|lipid binding|proteasomal protein catabolic process|positive regulation of mitochondrial membrane potential|macroautophagy|protein ubiquitination|protein deubiquitination|ATPase activity|protein N-linked glycosylation via asparagine|viral genome replication|protein phosphatase binding|protein domain specific binding|translesion synthesis|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|retrograde protein transport, ER to cytosol|positive regulation of protein complex assembly|polyubiquitin modification-dependent protein binding|ubiquitin protein ligase binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|endosome to lysosome transport via multivesicular body sorting pathway|VCP-NPL4-UFD1 AAA ATPase complex|protein hexamerization|secretory granule lumen|azurophil granule lumen|deubiquitinase activator activity|site of double-strand break|K48-linked polyubiquitin modification-dependent protein binding|ERAD pathway|Derlin-1 retrotranslocation complex|MHC class I protein binding|identical protein binding|regulation of apoptotic process|proteasome-mediated ubiquitin-dependent protein catabolic process|myelin sheath|intracellular membrane-bounded organelle|protein complex|neutrophil degranulation|ADP binding|ubiquitin-like protein ligase binding|establishment of protein localization|positive regulation of protein catabolic process|ATP metabolic process|perinuclear region of cytoplasm|protein homooligomerization|transmembrane transport|endoplasmic reticulum stress-induced pre-emptive quality control|extracellular exosome|aggresome assembly|error-free translesion synthesis|ER-associated misfolded protein catabolic process|flavin adenine dinucleotide catabolic process|autophagosome maturation|positive regulation of protein K63-linked deubiquitination|positive regulation of Lys63-specific deubiquitinase activity|regulation of aerobic respiration|positive regulation of oxidative phosphorylation|BAT3 complex binding|ficolin-1-rich granule lumen|ATPase complex|ubiquitin-specific protease binding|VCP-NSFL1C complex|positive regulation of ATP biosynthetic process hsa04141,hsa05134 Protein processing in endoplasmic reticulum|Legionellosis VCPIP1 202.499765368743 202.875683751821 202.123846985666 0.996294101134984 -0.00535641321909069 0.99952883831443 1 1.23193 0.996833 1.36046 0.884026 GeneID:80124,Genbank:NM_025054.4,HGNC:HGNC:30897,MIM:611745 valosin containing protein interacting protein 1 GO:0000278,GO:0004843,GO:0005737,GO:0005788,GO:0005795,GO:0016320,GO:0016567,GO:0016579,GO:0035871,GO:0071108,GO:0090168 mitotic cell cycle|thiol-dependent ubiquitin-specific protease activity|cytoplasm|endoplasmic reticulum lumen|Golgi stack|endoplasmic reticulum membrane fusion|protein ubiquitination|protein deubiquitination|protein K11-linked deubiquitination|protein K48-linked deubiquitination|Golgi reassembly VCPKMT 72.8031161572328 93.7456825962015 51.8605497182641 0.55320467334637 -0.854114750790217 0.0391615335589284 0.753859521009372 0.362941 0.269822 0.216062 0.175833 GeneID:79609,Genbank:XM_017021641.2,HGNC:HGNC:20352,MIM:615260 valosin containing protein lysine methyltransferase GO:0005737,GO:0005829,GO:0006479,GO:0016279,GO:0018022,GO:0018023,GO:0032780,GO:0043234,GO:0051117 cytoplasm|cytosol|protein methylation|protein-lysine N-methyltransferase activity|peptidyl-lysine methylation|peptidyl-lysine trimethylation|negative regulation of ATPase activity|protein complex|ATPase binding VDAC1 8727.77681355833 9357.47097289177 8098.08265422488 0.865413601354972 -0.20853829969589 0.110233575525017 1 157.362 159.035 142.451 135.397 GeneID:7416,Genbank:NM_003374.2,HGNC:HGNC:12669,MIM:604492 voltage dependent anion channel 1 hsa04020,hsa04022,hsa04217,hsa04218,hsa04621,hsa04979,hsa05012,hsa05016,hsa05164,hsa05166 Calcium signaling pathway|cGMP-PKG signaling pathway|Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Cholesterol metabolism|Parkinson disease|Huntington disease|Influenza A|Human T-cell leukemia virus 1 infection VDAC2 4349.42343108364 4512.34018767414 4186.50667449315 0.927790569941727 -0.10812891216959 0.418693146570927 1 70.8223 72.0161 64.8808 69.3516 GeneID:7417,Genbank:NM_001184783.2,HGNC:HGNC:12672,MIM:193245 voltage dependent anion channel 2 GO:0000166,GO:0001669,GO:0005634,GO:0005739,GO:0005741,GO:0005743,GO:0006820,GO:0007339,GO:0008021,GO:0008308,GO:0015288,GO:0032272,GO:0042645,GO:0043209,GO:0045121,GO:0046930,GO:0070062,GO:2001243 nucleotide binding|acrosomal vesicle|nucleus|mitochondrion|mitochondrial outer membrane|mitochondrial inner membrane|anion transport|binding of sperm to zona pellucida|synaptic vesicle|voltage-gated anion channel activity|porin activity|negative regulation of protein polymerization|mitochondrial nucleoid|myelin sheath|membrane raft|pore complex|extracellular exosome|negative regulation of intrinsic apoptotic signaling pathway hsa04020,hsa04022,hsa04216,hsa04217,hsa04218,hsa04621,hsa04979,hsa05012,hsa05016,hsa05166 Calcium signaling pathway|cGMP-PKG signaling pathway|Ferroptosis|Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Cholesterol metabolism|Parkinson disease|Huntington disease|Human T-cell leukemia virus 1 infection VDAC3 3126.30710946152 3128.3089380194 3124.30528090364 0.998720184868221 -0.00184756546733631 0.984390878902548 1 60.6422 62.98 60.8118 63.0408 GeneID:7419,Genbank:XM_006716394.1,HGNC:HGNC:12674,MIM:610029 voltage dependent anion channel 3 GO:0000166,GO:0005741,GO:0008308,GO:0015288,GO:0046930,GO:1902017 nucleotide binding|mitochondrial outer membrane|voltage-gated anion channel activity|porin activity|pore complex|regulation of cilium assembly hsa04020,hsa04022,hsa04216,hsa04217,hsa04218,hsa04621,hsa04979,hsa05012,hsa05016,hsa05161,hsa05166,hsa05203 Calcium signaling pathway|cGMP-PKG signaling pathway|Ferroptosis|Necroptosis|Cellular senescence|NOD-like receptor signaling pathway|Cholesterol metabolism|Parkinson disease|Huntington disease|Hepatitis B|Human T-cell leukemia virus 1 infection|Viral carcinogenesis VDR 339.534810690325 337.883416661811 341.186204718839 1.00977493388003 0.0140337702459492 0.94407337691724 1 2.32885 2.25081 2.45772 2.18117 GeneID:7421,Genbank:NM_000376.2,HGNC:HGNC:12679,MIM:601769 vitamin D receptor hsa04928,hsa04961,hsa04978,hsa05152 Parathyroid hormone synthesis, secretion and action|Endocrine and other factor-regulated calcium reabsorption|Mineral absorption|Tuberculosis VEGFA 3133.55967135775 3047.08459781088 3220.03474490463 1.05675922067211 0.0796467005493496 0.68037688421806 1 29.6203 31.3224 29.3155 35.5914 GeneID:7422,Genbank:NM_001025366.2,HGNC:HGNC:12680,MIM:192240 vascular endothelial growth factor A GO:0001525,GO:0001666,GO:0001934,GO:0001938,GO:0001968,GO:0002042,GO:0002092,GO:0005125,GO:0005161,GO:0005172,GO:0005615,GO:0005737,GO:0008083,GO:0008201,GO:0008284,GO:0008360,GO:0009986,GO:0010595,GO:0016020,GO:0030141,GO:0030224,GO:0030225,GO:0030949,GO:0031334,GO:0031954,GO:0032147,GO:0032793,GO:0033138,GO:0035148,GO:0035767,GO:0035924,GO:0038033,GO:0038091,GO:0042056,GO:0043066,GO:0043183,GO:0043184,GO:0043406,GO:0043536,GO:0045766,GO:0045785,GO:0045944,GO:0048010,GO:0048018,GO:0050731,GO:0050918,GO:0050927,GO:0050930,GO:0051272,GO:0051781,GO:0051894,GO:0060754,GO:0071456,GO:0090037,GO:0090050,GO:0097475,GO:1900086,GO:1903572 angiogenesis|response to hypoxia|positive regulation of protein phosphorylation|positive regulation of endothelial cell proliferation|fibronectin binding|cell migration involved in sprouting angiogenesis|positive regulation of receptor internalization|cytokine activity|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor binding|extracellular space|cytoplasm|growth factor activity|heparin binding|positive regulation of cell proliferation|regulation of cell shape|cell surface|positive regulation of endothelial cell migration|membrane|secretory granule|monocyte differentiation|macrophage differentiation|positive regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of protein complex assembly|positive regulation of protein autophosphorylation|activation of protein kinase activity|positive regulation of CREB transcription factor activity|positive regulation of peptidyl-serine phosphorylation|tube formation|endothelial cell chemotaxis|cellular response to vascular endothelial growth factor stimulus|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway|chemoattractant activity|negative regulation of apoptotic process|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|positive regulation of MAP kinase activity|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of cell adhesion|positive regulation of transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway|receptor ligand activity|positive regulation of peptidyl-tyrosine phosphorylation|positive chemotaxis|positive regulation of positive chemotaxis|induction of positive chemotaxis|positive regulation of cellular component movement|positive regulation of cell division|positive regulation of focal adhesion assembly|positive regulation of mast cell chemotaxis|cellular response to hypoxia|positive regulation of protein kinase C signaling|positive regulation of cell migration involved in sprouting angiogenesis|motor neuron migration|positive regulation of peptidyl-tyrosine autophosphorylation|positive regulation of protein kinase D signaling hsa01521,hsa04010,hsa04014,hsa04015,hsa04066,hsa04151,hsa04370,hsa04510,hsa04926,hsa04933,hsa05163,hsa05165,hsa05167,hsa05200,hsa05205,hsa05206,hsa05211,hsa05212,hsa05219,hsa05323,hsa05418 EGFR tyrosine kinase inhibitor resistance|MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|HIF-1 signaling pathway|PI3K-Akt signaling pathway|VEGF signaling pathway|Focal adhesion|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Human cytomegalovirus infection|Human papillomavirus infection|Kaposi sarcoma-associated herpesvirus infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Renal cell carcinoma|Pancreatic cancer|Bladder cancer|Rheumatoid arthritis|Fluid shear stress and atherosclerosis VEGFB 1360.10786374462 1233.9205981809 1486.29512930835 1.20453060877622 0.268471054903556 0.0708151668886316 0.924040800265082 27.9414 29.5025 34.4951 35.6405 GeneID:7423,Genbank:NM_003377.4,HGNC:HGNC:12681,MIM:601398 vascular endothelial growth factor B GO:0001525,GO:0001666,GO:0001938,GO:0002576,GO:0005576,GO:0005615,GO:0006493,GO:0008083,GO:0008201,GO:0010629,GO:0016020,GO:0030949,GO:0031093,GO:0035470,GO:0042056,GO:0042493,GO:0042803,GO:0043066,GO:0043183,GO:0043184,GO:0043524,GO:0045766,GO:0046982,GO:0048010,GO:0050731,GO:0050930,GO:0051781,GO:0051897,GO:0060048,GO:0060754,GO:0060976,GO:0070374 angiogenesis|response to hypoxia|positive regulation of endothelial cell proliferation|platelet degranulation|extracellular region|extracellular space|protein O-linked glycosylation|growth factor activity|heparin binding|negative regulation of gene expression|membrane|positive regulation of vascular endothelial growth factor receptor signaling pathway|platelet alpha granule lumen|positive regulation of vascular wound healing|chemoattractant activity|response to drug|protein homodimerization activity|negative regulation of apoptotic process|vascular endothelial growth factor receptor 1 binding|vascular endothelial growth factor receptor 2 binding|negative regulation of neuron apoptotic process|positive regulation of angiogenesis|protein heterodimerization activity|vascular endothelial growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|induction of positive chemotaxis|positive regulation of cell division|positive regulation of protein kinase B signaling|cardiac muscle contraction|positive regulation of mast cell chemotaxis|coronary vasculature development|positive regulation of ERK1 and ERK2 cascade hsa04010,hsa04014,hsa04015,hsa04151,hsa04510,hsa04926,hsa04933,hsa05200 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer VEGFC 294.665220183266 321.288632580161 268.04180778637 0.834271059121564 -0.261411895731149 0.236944995494037 1 5.35419 5.21934 5.40103 3.58335 GeneID:7424,Genbank:NM_005429.4,HGNC:HGNC:12682,MIM:601528 vascular endothelial growth factor C GO:0001525,GO:0001666,GO:0001938,GO:0001954,GO:0002052,GO:0002576,GO:0005576,GO:0005615,GO:0006929,GO:0007165,GO:0008083,GO:0008284,GO:0008285,GO:0009887,GO:0016020,GO:0016331,GO:0030947,GO:0031093,GO:0031954,GO:0042056,GO:0042493,GO:0043185,GO:0043536,GO:0045766,GO:0045776,GO:0048010,GO:0050714,GO:0050731,GO:0050930,GO:0051781,GO:0060754,GO:1901492,GO:1990830 angiogenesis|response to hypoxia|positive regulation of endothelial cell proliferation|positive regulation of cell-matrix adhesion|positive regulation of neuroblast proliferation|platelet degranulation|extracellular region|extracellular space|substrate-dependent cell migration|signal transduction|growth factor activity|positive regulation of cell proliferation|negative regulation of cell proliferation|animal organ morphogenesis|membrane|morphogenesis of embryonic epithelium|regulation of vascular endothelial growth factor receptor signaling pathway|platelet alpha granule lumen|positive regulation of protein autophosphorylation|chemoattractant activity|response to drug|vascular endothelial growth factor receptor 3 binding|positive regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|negative regulation of blood pressure|vascular endothelial growth factor receptor signaling pathway|positive regulation of protein secretion|positive regulation of peptidyl-tyrosine phosphorylation|induction of positive chemotaxis|positive regulation of cell division|positive regulation of mast cell chemotaxis|positive regulation of lymphangiogenesis|cellular response to leukemia inhibitory factor hsa04010,hsa04014,hsa04015,hsa04151,hsa04510,hsa04668,hsa04926,hsa04933,hsa05200 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|TNF signaling pathway|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer VEGFD 3.94227703541278 3.03648096111406 4.84807310971151 1.59660909183926 0.675011131597949 0.738174294581676 1 0.0220316 0.0819423 0.104563 0.0195047 GeneID:2277,Genbank:NM_004469.4,HGNC:HGNC:3708,MIM:300091 vascular endothelial growth factor D hsa04010,hsa04014,hsa04015,hsa04151,hsa04510,hsa04926,hsa04933,hsa05200 MAPK signaling pathway|Ras signaling pathway|Rap1 signaling pathway|PI3K-Akt signaling pathway|Focal adhesion|Relaxin signaling pathway|AGE-RAGE signaling pathway in diabetic complications|Pathways in cancer VEPH1 23.393558680282 30.3069746813477 16.4801426792162 0.54377392836108 -0.878921112935989 0.137828414609053 1 0.128878 0.172861 0.0558226 0.0749597 GeneID:79674,Genbank:XM_024453748.1,HGNC:HGNC:25735,MIM:609594 ventricular zone expressed PH domain containing 1 GO:0005886 plasma membrane VEZF1 1969.753714315 1991.65955779692 1947.84787083308 0.978002421753088 -0.0320900572693169 0.839240426060038 1 15.0452 14.6743 16.2179 13.2928 GeneID:7716,Genbank:NM_001330393.1,HGNC:HGNC:12949,MIM:606747 vascular endothelial zinc finger 1 GO:0000977,GO:0001228,GO:0001525,GO:0001885,GO:0005654,GO:0006357,GO:0006366,GO:0006968,GO:0045944,GO:0046872 RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|angiogenesis|endothelial cell development|nucleoplasm|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|cellular defense response|positive regulation of transcription from RNA polymerase II promoter|metal ion binding VEZT 635.325921971519 665.340046712715 605.311797230323 0.909778090498268 -0.136413403179424 0.435814003966076 1 3.63322 3.07245 3.16083 3.02582 GeneID:55591,Genbank:NM_001352092.1,HGNC:HGNC:18258 vezatin, adherens junctions transmembrane protein GO:0001669,GO:0005654,GO:0005829,GO:0005886,GO:0005912,GO:0016021,GO:0017022,GO:0098609 acrosomal vesicle|nucleoplasm|cytosol|plasma membrane|adherens junction|integral component of membrane|myosin binding|cell-cell adhesion VGF 63.5441272405134 58.2694535573864 68.8188009236403 1.1810442130861 0.240062973885034 0.529038944406827 1 1.02906 1.04906 1.34678 1.17304 GeneID:7425,Genbank:NM_003378.3,HGNC:HGNC:12684,MIM:602186 VGF nerve growth factor inducible GO:0001541,GO:0002021,GO:0005179,GO:0005184,GO:0005615,GO:0005788,GO:0005794,GO:0006091,GO:0008083,GO:0009409,GO:0019953,GO:0030073,GO:0030133,GO:0031410,GO:0032868,GO:0033500,GO:0042593,GO:0042742,GO:0043231,GO:0043687,GO:0044267,GO:0048167,GO:0051591 ovarian follicle development|response to dietary excess|hormone activity|neuropeptide hormone activity|extracellular space|endoplasmic reticulum lumen|Golgi apparatus|generation of precursor metabolites and energy|growth factor activity|response to cold|sexual reproduction|insulin secretion|transport vesicle|cytoplasmic vesicle|response to insulin|carbohydrate homeostasis|glucose homeostasis|defense response to bacterium|intracellular membrane-bounded organelle|post-translational protein modification|cellular protein metabolic process|regulation of synaptic plasticity|response to cAMP VGLL2 81.8431622654236 86.6161426309046 77.0701818999426 0.889790050202998 -0.168463128766392 0.612220662043212 1 1.85018 1.87418 1.93476 1.36016 GeneID:245806,Genbank:NM_182645.3,HGNC:HGNC:20232,MIM:609979 vestigial like family member 2 GO:0003713,GO:0005634,GO:0005737,GO:0006351,GO:0007519,GO:0008022,GO:0045944 transcription coactivator activity|nucleus|cytoplasm|transcription, DNA-templated|skeletal muscle tissue development|protein C-terminus binding|positive regulation of transcription from RNA polymerase II promoter VGLL3 59.8539348596638 58.1537836978006 61.554086021527 1.05847086995055 0.0819815656552098 0.824750888144499 1 0.28286 0.181909 0.282245 0.219867 GeneID:389136,Genbank:NM_001320494.1,HGNC:HGNC:24327,MIM:609980 vestigial like family member 3 GO:0005634,GO:0006351,GO:0006357 nucleus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter VGLL4 2416.26345727154 2107.41246120823 2725.11445333484 1.29310920548152 0.370844118577202 0.00751932983034324 0.341216961574625 15.1174 15.3015 20.7628 19.1252 GeneID:9686,Genbank:NM_014667.3,HGNC:HGNC:28966 vestigial like family member 4 GO:0005634,GO:0006351,GO:0006355 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated VHL 2831.74341094208 3060.13321221924 2603.35360966493 0.850732118219436 -0.233223172796129 0.0859339469159649 0.964561165794104 27.1196 29.0013 23.6053 24.2924 GeneID:7428,Genbank:NM_001354723.1,HGNC:HGNC:12687,MIM:608537 von Hippel-Lindau tumor suppressor hsa04066,hsa04120,hsa05200,hsa05211 HIF-1 signaling pathway|Ubiquitin mediated proteolysis|Pathways in cancer|Renal cell carcinoma VHLL 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0593072 0 0 0 GeneID:391104,Genbank:NM_001004319.2,HGNC:HGNC:30666 VHL like GO:0005634,GO:0016567,GO:0030891,GO:0061630 nucleus|protein ubiquitination|VCB complex|ubiquitin protein ligase activity VILL 1.94310137958538 0.980142803914724 2.90605995525603 2.96493525601487 1.56800060161914 0.614356592326726 1 0 0.0133554 0 0.0132116 GeneID:50853,Genbank:XM_011533773.2,HGNC:HGNC:30906 villin like GO:0005200,GO:0015629,GO:0051015,GO:0051693 structural constituent of cytoskeleton|actin cytoskeleton|actin filament binding|actin filament capping VIM 150470.647842799 152903.696439157 148037.599246442 0.968175411673905 -0.046659639716242 0.712757214163889 1 2934.26 2909.37 2836.2 2882.23 GeneID:7431,Genbank:NM_003380.4,HGNC:HGNC:12692,MIM:193060 vimentin hsa05169,hsa05206 Epstein-Barr virus infection|MicroRNAs in cancer VIP 0.727167467854057 0 1.45433493570811 Inf Inf 0.598652320426703 1 0 0 0.0547767 0.0255994 GeneID:7432,Genbank:NM_003381.3,HGNC:HGNC:12693,MIM:192320 vasoactive intestinal peptide hsa04080 Neuroactive ligand-receptor interaction VIPAS39 380.890821247664 374.58093687882 387.200705616508 1.03369036567328 0.0478041017021764 0.819157549596619 1 2.85913 3.33557 3.02685 3.50232 GeneID:63894,Genbank:XM_024449688.1,HGNC:HGNC:20347,MIM:613401 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog GO:0005737,GO:0005769,GO:0005770,GO:0005794,GO:0006351,GO:0006355,GO:0006886,GO:0007283,GO:0008333,GO:0017185,GO:0030154,GO:0030199,GO:0032963,GO:0043687,GO:0055037 cytoplasm|early endosome|late endosome|Golgi apparatus|transcription, DNA-templated|regulation of transcription, DNA-templated|intracellular protein transport|spermatogenesis|endosome to lysosome transport|peptidyl-lysine hydroxylation|cell differentiation|collagen fibril organization|collagen metabolic process|post-translational protein modification|recycling endosome VIRMA 805.726500579193 853.880215294789 757.572785863597 0.887212014394849 -0.172649192653624 0.372112997720398 1 3.83143 3.78984 3.99888 2.83004 GeneID:25962,Genbank:NM_015496.4,HGNC:HGNC:24500,MIM:616447 vir like m6A methyltransferase associated GO:0003723,GO:0005654,GO:0005829,GO:0006397,GO:0008380,GO:0016604,GO:0016607,GO:0080009 RNA binding|nucleoplasm|cytosol|mRNA processing|RNA splicing|nuclear body|nuclear speck|mRNA methylation VIT 81.0275093670997 51.5525327540381 110.502485980161 2.14349286207486 1.09996361292519 0.000774462764870072 0.0855434182217868 0.227419 0.217573 0.604251 0.507809 GeneID:5212,Genbank:NM_053276.3,HGNC:HGNC:12697,MIM:617693 vitrin GO:0005539,GO:0005614,GO:0010811,GO:0030198 glycosaminoglycan binding|interstitial matrix|positive regulation of cell-substrate adhesion|extracellular matrix organization VKORC1 1549.86129420947 1511.15286486129 1588.56972355765 1.0512303291722 0.0720788047408431 0.648291769792695 1 63.9251 71.1744 73.1424 73.5325 GeneID:79001,Genbank:NM_206824.2,HGNC:HGNC:23663,MIM:608547 vitamin K epoxide reductase complex subunit 1 hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis VKORC1L1 1816.49692765259 1973.50933261599 1659.48452268919 0.840879997506501 -0.250028167599817 0.0789327467526315 0.945231254824065 14.6373 14.7544 13.7571 11.1869 GeneID:154807,Genbank:XM_011515831.3,HGNC:HGNC:21492,MIM:608838 vitamin K epoxide reductase complex subunit 1 like 1 GO:0005783,GO:0005789,GO:0016021,GO:0017187,GO:0034599,GO:0042373,GO:0047057,GO:0048038 endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|peptidyl-glutamic acid carboxylation|cellular response to oxidative stress|vitamin K metabolic process|vitamin-K-epoxide reductase (warfarin-sensitive) activity|quinone binding hsa00130 Ubiquinone and other terpenoid-quinone biosynthesis VLDLR 1685.47175550289 1616.60918382722 1754.33432717856 1.08519383950627 0.117952762777589 0.403294586353593 1 11.5135 11.3446 12.5683 12.2791 GeneID:7436,Genbank:NM_003383.4,HGNC:HGNC:12698,MIM:192977 very low density lipoprotein receptor VMA21 1605.77339235206 1728.93732807651 1482.60945662761 0.857526431150083 -0.221746955378613 0.205753375317298 1 19.4246 17.4903 17.9486 14.0113 GeneID:203547,Genbank:XM_011531125.2,HGNC:HGNC:22082,MIM:300913 VMA21, vacuolar ATPase assembly factor GO:0005764,GO:0005789,GO:0012507,GO:0016021,GO:0033116,GO:0070072 lysosome|endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|integral component of membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|vacuolar proton-transporting V-type ATPase complex assembly VMAC 163.790473748938 157.963636561977 169.617310935898 1.07377441180489 0.102690930795177 0.699949449272288 1 4.51888 4.79594 5.09387 5.0374 GeneID:400673,Genbank:NM_001017921.3,HGNC:HGNC:33803,MIM:617204 vimentin type intermediate filament associated coiled-coil protein GO:0005737 cytoplasm VMO1 6.68708684456473 4.65077399104097 8.72339969808849 1.87568772743909 0.907419661768693 0.451881123946016 1 0.272925 0.155651 0.418682 0.467428 GeneID:284013,Genbank:NM_001144941.1,HGNC:HGNC:30387 vitelline membrane outer layer 1 homolog GO:0070062 extracellular exosome VMP1 5999.07853258359 6105.27779737993 5892.87926778726 0.965210669089649 -0.0510842322163571 0.716954657901674 1 58.7559 55.6555 54.5492 56.4812 GeneID:81671,Genbank:NM_001329394.1,HGNC:HGNC:29559,MIM:611753 vacuole membrane protein 1 hsa04140 Autophagy - animal VN1R1 6.15236068966092 4.06465003971372 8.24007133960811 2.02725234868891 1.01952568404024 0.43113191179591 1 0.0329349 0.0938302 0.188993 0.0883547 GeneID:57191,Genbank:NM_020633.3,HGNC:HGNC:13548,MIM:605234 vomeronasal 1 receptor 1 VN1R5 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.105849 0 0 GeneID:317705,Genbank:NM_173858.1,HGNC:HGNC:19870 vomeronasal 1 receptor 5 (gene/pseudogene) VNN1 7.14901198186282 4.60274771635603 9.69527624736962 2.1064105279803 1.07478663720066 0.354234028917401 1 0.0310597 0.0497119 0.119612 0.0650452 GeneID:8876,Genbank:NM_004666.2,HGNC:HGNC:12705,MIM:603570 vanin 1 hsa00770 Pantothenate and CoA biosynthesis VNN2 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:8875,Genbank:XM_017011408.1,HGNC:HGNC:12706,MIM:603571 vanin 2 hsa00770 Pantothenate and CoA biosynthesis VOPP1 3632.61759033357 2953.42515910894 4311.8100215582 1.45993542726476 0.54590456032099 5.83358325563111e-05 0.0176284281928656 13.5573 14.4941 21.8229 19.9143 GeneID:81552,Genbank:XM_011515539.1,HGNC:HGNC:34518,MIM:611915 VOPP1, WBP1/VOPP1 family member GO:0004871,GO:0005768,GO:0006351,GO:0006355,GO:0030659,GO:0031301 signal transducer activity|endosome|transcription, DNA-templated|regulation of transcription, DNA-templated|cytoplasmic vesicle membrane|integral component of organelle membrane VPS11 864.698296569776 864.364836835487 865.031756304065 1.00077157172545 0.00111271348804837 0.996969005011488 1 5.91264 6.37374 6.05887 6.38731 GeneID:55823,Genbank:NM_001290185.1,HGNC:HGNC:14583,MIM:608549 VPS11, CORVET/HOPS core subunit GO:0000166,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005776,GO:0006886,GO:0006904,GO:0006914,GO:0007032,GO:0007040,GO:0008333,GO:0019904,GO:0019905,GO:0030136,GO:0030139,GO:0030674,GO:0030897,GO:0031647,GO:0031902,GO:0034058,GO:0035542,GO:0046872,GO:1902115,GO:1903364,GO:1903955,GO:2000643 nucleotide binding|lysosome|lysosomal membrane|endosome|early endosome|late endosome|autophagosome|intracellular protein transport|vesicle docking involved in exocytosis|autophagy|endosome organization|lysosome organization|endosome to lysosome transport|protein domain specific binding|syntaxin binding|clathrin-coated vesicle|endocytic vesicle|protein binding, bridging|HOPS complex|regulation of protein stability|late endosome membrane|endosomal vesicle fusion|regulation of SNARE complex assembly|metal ion binding|regulation of organelle assembly|positive regulation of cellular protein catabolic process|positive regulation of protein targeting to mitochondrion|positive regulation of early endosome to late endosome transport VPS13A 96.0323980836185 93.6594387019395 98.4053574652975 1.05067208205744 0.0713124700540389 0.874091050412856 1 0.258564 0.247718 0.363308 0.187281 GeneID:23230,Genbank:NM_033305.2,HGNC:HGNC:1908,MIM:605978 vacuolar protein sorting 13 homolog A GO:0005622,GO:0005829,GO:0006895,GO:0006914,GO:0007399,GO:0007626,GO:0008104,GO:0015031,GO:0031045,GO:0035176 intracellular|cytosol|Golgi to endosome transport|autophagy|nervous system development|locomotory behavior|protein localization|protein transport|dense core granule|social behavior VPS13B 236.762052865187 232.596534481841 240.927571248532 1.03581754468204 0.050769900163179 0.90719873098053 1 0.427066 0.345748 0.56585 0.269515 GeneID:157680,Genbank:XM_005250801.5,HGNC:HGNC:2183,MIM:607817 vacuolar protein sorting 13 homolog B GO:0015031 protein transport VPS13C 197.026371725959 175.413084932848 218.639658519071 1.24642730388541 0.317798742129538 0.592407890087618 1 0.362563 0.290908 0.592743 0.256991 GeneID:54832,Genbank:NM_017684.4,HGNC:HGNC:23594,MIM:608879 vacuolar protein sorting 13 homolog C GO:0005737,GO:0005741,GO:0005829,GO:0006895,GO:0007005,GO:0070062,GO:1905090 cytoplasm|mitochondrial outer membrane|cytosol|Golgi to endosome transport|mitochondrion organization|extracellular exosome|negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization VPS13D 1716.67322778794 1672.98599536167 1760.3604602142 1.05222665646621 0.073445504001607 0.652790831965588 1 3.38851 3.43593 4.20838 3.10213 GeneID:55187,Genbank:NM_015378.3,HGNC:HGNC:23595,MIM:608877 vacuolar protein sorting 13 homolog D GO:0070062 extracellular exosome VPS16 376.560979607251 356.688426379822 396.433532834679 1.11142807984617 0.152414595052898 0.416615997534269 1 7.16405 6.31505 7.96266 7.31655 GeneID:64601,Genbank:NM_022575.3,HGNC:HGNC:14584,MIM:608550 VPS16, CORVET/HOPS core subunit GO:0003779,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005776,GO:0006886,GO:0007033,GO:0008333,GO:0030136,GO:0030424,GO:0030897,GO:0031902,GO:0032889,GO:0035542,GO:0043025,GO:0051015,GO:0055037,GO:0097352 actin binding|lysosome|lysosomal membrane|early endosome|late endosome|autophagosome|intracellular protein transport|vacuole organization|endosome to lysosome transport|clathrin-coated vesicle|axon|HOPS complex|late endosome membrane|regulation of vacuole fusion, non-autophagic|regulation of SNARE complex assembly|neuronal cell body|actin filament binding|recycling endosome|autophagosome maturation VPS18 2321.52685536111 2161.37916735419 2481.67454336803 1.14819027630674 0.199361743004132 0.160142735236622 1 21.2419 22.8143 25.01 26.3296 GeneID:57617,Genbank:XM_017022447.1,HGNC:HGNC:15972,MIM:608551 VPS18, CORVET/HOPS core subunit GO:0003779,GO:0005764,GO:0005765,GO:0005769,GO:0005770,GO:0005776,GO:0005884,GO:0006886,GO:0006904,GO:0006914,GO:0007032,GO:0007040,GO:0008333,GO:0019905,GO:0030123,GO:0030136,GO:0030674,GO:0030897,GO:0031902,GO:0033263,GO:0035542,GO:0046718,GO:0046872 actin binding|lysosome|lysosomal membrane|early endosome|late endosome|autophagosome|actin filament|intracellular protein transport|vesicle docking involved in exocytosis|autophagy|endosome organization|lysosome organization|endosome to lysosome transport|syntaxin binding|AP-3 adaptor complex|clathrin-coated vesicle|protein binding, bridging|HOPS complex|late endosome membrane|CORVET complex|regulation of SNARE complex assembly|viral entry into host cell|metal ion binding VPS25 1329.98269828514 1779.69506547283 880.270331097447 0.494618627749904 -1.0156115210383 0.00720573600567024 0.338869203906778 60.4557 59.7615 18.684 40.0099 GeneID:84313,Genbank:NM_032353.3,HGNC:HGNC:28122,MIM:610907 vacuolar protein sorting 25 homolog GO:0000814,GO:0005198,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0007175,GO:0010008,GO:0016197,GO:0016236,GO:0036258,GO:0042803,GO:0043328,GO:0047485,GO:0070062 ESCRT II complex|structural molecule activity|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of epidermal growth factor-activated receptor activity|endosome membrane|endosomal transport|macroautophagy|multivesicular body assembly|protein homodimerization activity|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein N-terminus binding|extracellular exosome hsa04144 Endocytosis VPS26A 987.940315152313 1021.10514821756 954.775482087066 0.935041296925904 -0.096898010577452 0.638264592819505 1 9.70929 8.28453 9.19888 7.93565 GeneID:9559,Genbank:NM_001318944.1,HGNC:HGNC:12711,MIM:605506 VPS26, retromer complex component A GO:0005764,GO:0005768,GO:0005769,GO:0005829,GO:0006886,GO:0008565,GO:0010008,GO:0016055,GO:0016241,GO:0030904,GO:0030906,GO:0031982,GO:0042147,GO:0070062,GO:0097422,GO:1990126 lysosome|endosome|early endosome|cytosol|intracellular protein transport|protein transporter activity|endosome membrane|Wnt signaling pathway|regulation of macroautophagy|retromer complex|retromer, cargo-selective complex|vesicle|retrograde transport, endosome to Golgi|extracellular exosome|tubular endosome|retrograde transport, endosome to plasma membrane hsa04144 Endocytosis VPS26B 1124.30777480224 1071.45905810619 1177.15649149829 1.09864813087579 0.135729401642968 0.369742062339894 1 9.85049 9.85527 11.4443 10.988 GeneID:112936,Genbank:NM_052875.4,HGNC:HGNC:28119,MIM:610027 VPS26, retromer complex component B GO:0005768,GO:0005769,GO:0005770,GO:0005829,GO:0006886,GO:0008565,GO:0016241,GO:0030904,GO:0030906,GO:0042147,GO:0045335,GO:0071346 endosome|early endosome|late endosome|cytosol|intracellular protein transport|protein transporter activity|regulation of macroautophagy|retromer complex|retromer, cargo-selective complex|retrograde transport, endosome to Golgi|phagocytic vesicle|cellular response to interferon-gamma hsa04144 Endocytosis VPS26C 1487.53117878911 1290.47868915813 1684.58366842009 1.3053944110608 0.384485767647213 0.00821100793399391 0.355592583438871 14.0627 14.0665 19.1604 18.0257 GeneID:10311,Genbank:NM_001331018.1,HGNC:HGNC:3044,MIM:605298 VPS26 endosomal protein sorting factor C GO:0005634,GO:0005768,GO:0006886,GO:0008565 nucleus|endosome|intracellular protein transport|protein transporter activity VPS28 823.854603003831 814.666728484801 833.042477522861 1.02255615504543 0.0321800728795079 0.854746377189902 1 13.5314 14.0381 15.7128 13.2523 GeneID:51160,Genbank:NM_016208.3,HGNC:HGNC:18178,MIM:611952 VPS28, ESCRT-I subunit GO:0000813,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0010008,GO:0016197,GO:0016236,GO:0019058,GO:0031397,GO:0031902,GO:0032403,GO:0036258,GO:0039702,GO:0043130,GO:0043162,GO:0043328,GO:0043657,GO:0045732,GO:0070062,GO:0075733,GO:2000397 ESCRT I complex|cytoplasm|endosome|early endosome|cytosol|plasma membrane|endosome membrane|endosomal transport|macroautophagy|viral life cycle|negative regulation of protein ubiquitination|late endosome membrane|protein complex binding|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin binding|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|host cell|positive regulation of protein catabolic process|extracellular exosome|intracellular transport of virus|positive regulation of ubiquitin-dependent endocytosis hsa04144 Endocytosis VPS29 1502.35826902248 1568.86155242925 1435.85498561571 0.915220966051725 -0.127807992866789 0.386252373394012 1 36.5461 36.0522 32.3005 34.7025 GeneID:51699,Genbank:NM_001282151.1,HGNC:HGNC:14340,MIM:606932 VPS29, retromer complex component GO:0005768,GO:0005769,GO:0005770,GO:0005829,GO:0006886,GO:0008270,GO:0010008,GO:0030904,GO:0042147,GO:1990126 endosome|early endosome|late endosome|cytosol|intracellular protein transport|zinc ion binding|endosome membrane|retromer complex|retrograde transport, endosome to Golgi|retrograde transport, endosome to plasma membrane hsa04144 Endocytosis VPS33A 845.980712014824 845.357913363628 846.60351066602 1.00147345554197 0.00212418244319981 1 1 4.75538 5.24129 4.74233 5.04842 GeneID:65082,Genbank:NM_001351020.1,HGNC:HGNC:18179,MIM:610034 VPS33A, CORVET/HOPS core subunit GO:0005765,GO:0005769,GO:0005770,GO:0005776,GO:0006904,GO:0008333,GO:0015031,GO:0016192,GO:0030136,GO:0030220,GO:0030897,GO:0031902,GO:0032400,GO:0032418,GO:0035751,GO:0048070,GO:0048471,GO:0097352 lysosomal membrane|early endosome|late endosome|autophagosome|vesicle docking involved in exocytosis|endosome to lysosome transport|protein transport|vesicle-mediated transport|clathrin-coated vesicle|platelet formation|HOPS complex|late endosome membrane|melanosome localization|lysosome localization|regulation of lysosomal lumen pH|regulation of developmental pigmentation|perinuclear region of cytoplasm|autophagosome maturation VPS33B 455.831716600924 457.122620814903 454.540812386946 0.994352044045961 -0.00817137561422586 0.964518769348577 1 4.94393 4.6738 4.56804 5.31631 GeneID:26276,Genbank:NM_001289148.1,HGNC:HGNC:12712,MIM:608552 VPS33B, late endosome and lysosome associated GO:0005737,GO:0005764,GO:0005765,GO:0005770,GO:0005794,GO:0006886,GO:0006904,GO:0007032,GO:0015031,GO:0016192,GO:0017185,GO:0030136,GO:0030199,GO:0031091,GO:0031901,GO:0031902,GO:0032400,GO:0032418,GO:0032963,GO:0035855,GO:0048471,GO:0055037,GO:0061025,GO:0070889,GO:0090330 cytoplasm|lysosome|lysosomal membrane|late endosome|Golgi apparatus|intracellular protein transport|vesicle docking involved in exocytosis|endosome organization|protein transport|vesicle-mediated transport|peptidyl-lysine hydroxylation|clathrin-coated vesicle|collagen fibril organization|platelet alpha granule|early endosome membrane|late endosome membrane|melanosome localization|lysosome localization|collagen metabolic process|megakaryocyte development|perinuclear region of cytoplasm|recycling endosome|membrane fusion|platelet alpha granule organization|regulation of platelet aggregation VPS35 3336.2088494869 3381.21586304214 3291.20183593166 0.97337820749797 -0.0389276197229209 0.791880850667742 1 21.762 20.6644 21.8699 20.0318 GeneID:55737,Genbank:NM_018206.5,HGNC:HGNC:13487,MIM:601501 VPS35, retromer complex component GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005829,GO:0007040,GO:0008565,GO:0010008,GO:0010628,GO:0010629,GO:0010821,GO:0014069,GO:0016055,GO:0016241,GO:0030904,GO:0030906,GO:0031647,GO:0031648,GO:0031748,GO:0032268,GO:0032463,GO:0033365,GO:0042147,GO:0043005,GO:0043025,GO:0043653,GO:0045056,GO:0048471,GO:0050728,GO:0050882,GO:0060161,GO:0060548,GO:0061357,GO:0070062,GO:0090141,GO:0090263,GO:0090326,GO:0097422,GO:0099073,GO:0099074,GO:0099639,GO:1901215,GO:1902823,GO:1902950,GO:1903181,GO:1903364,GO:1903828,GO:1905166,GO:1905606,GO:1990126,GO:2000331 lysosome|lysosomal membrane|endosome|early endosome|late endosome|cytosol|lysosome organization|protein transporter activity|endosome membrane|positive regulation of gene expression|negative regulation of gene expression|regulation of mitochondrion organization|postsynaptic density|Wnt signaling pathway|regulation of macroautophagy|retromer complex|retromer, cargo-selective complex|regulation of protein stability|protein destabilization|D1 dopamine receptor binding|regulation of cellular protein metabolic process|negative regulation of protein homooligomerization|protein localization to organelle|retrograde transport, endosome to Golgi|neuron projection|neuronal cell body|mitochondrial fragmentation involved in apoptotic process|transcytosis|perinuclear region of cytoplasm|negative regulation of inflammatory response|voluntary musculoskeletal movement|positive regulation of dopamine receptor signaling pathway|negative regulation of cell death|positive regulation of Wnt protein secretion|extracellular exosome|positive regulation of mitochondrial fission|positive regulation of canonical Wnt signaling pathway|positive regulation of locomotion involved in locomotory behavior|tubular endosome|mitochondrion-derived vesicle|mitochondrion to lysosome transport|neurotransmitter receptor transport, endosome to plasma membrane|negative regulation of neuron death|negative regulation of late endosome to lysosome transport|regulation of dendritic spine maintenance|positive regulation of dopamine biosynthetic process|positive regulation of cellular protein catabolic process|negative regulation of cellular protein localization|negative regulation of lysosomal protein catabolic process|regulation of presynapse assembly|retrograde transport, endosome to plasma membrane|regulation of terminal button organization hsa04144 Endocytosis VPS35L 1020.88702051158 926.679323122372 1115.09471790079 1.20332318859081 0.267024173650498 0.080739978142696 0.951623427935096 6.58073 6.82944 8.05508 8.15226 GeneID:57020,Genbank:XM_005255435.4,HGNC:HGNC:24641 VPS35 endosomal protein sorting factor like GO:0005769,GO:0005886,GO:0006893,GO:0015031,GO:0016021,GO:0043312,GO:0101003 early endosome|plasma membrane|Golgi to plasma membrane transport|protein transport|integral component of membrane|neutrophil degranulation|ficolin-1-rich granule membrane VPS36 515.548479254084 543.535832691105 487.561125817062 0.897017448515021 -0.156792046597606 0.387016984246053 1 5.02748 4.24854 4.38235 3.74059 GeneID:51028,Genbank:NM_001282168.1,HGNC:HGNC:20312,MIM:610903 vacuolar protein sorting 36 homolog GO:0000814,GO:0005634,GO:0005764,GO:0005768,GO:0005829,GO:0006351,GO:0006355,GO:0008022,GO:0016197,GO:0016236,GO:0031902,GO:0032266,GO:0036258,GO:0043130,GO:0043328,GO:0070062 ESCRT II complex|nucleus|lysosome|endosome|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|protein C-terminus binding|endosomal transport|macroautophagy|late endosome membrane|phosphatidylinositol-3-phosphate binding|multivesicular body assembly|ubiquitin binding|protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|extracellular exosome hsa04144 Endocytosis VPS37A 805.143936452497 827.089984321404 783.197888583591 0.946931897895215 -0.0786674222050953 0.63529524083484 1 2.97128 2.95338 3.0335 2.55603 GeneID:137492,Genbank:NM_152415.2,HGNC:HGNC:24928,MIM:609927 VPS37A, ESCRT-I subunit GO:0000813,GO:0005654,GO:0005813,GO:0005829,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0036258,GO:0039702,GO:0043162,GO:0043231,GO:0043657,GO:0075733 ESCRT I complex|nucleoplasm|centrosome|cytosol|endosome membrane|protein transport|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|intracellular membrane-bounded organelle|host cell|intracellular transport of virus hsa04144 Endocytosis VPS37B 1728.61296679777 1751.39843667571 1705.82749691984 0.973980255548038 -0.0380355684849334 0.766684978112125 1 10.067 11.5243 10.4671 10.5247 GeneID:79720,Genbank:NM_024667.2,HGNC:HGNC:25754,MIM:610037 VPS37B, ESCRT-I subunit GO:0000813,GO:0005737,GO:0005768,GO:0005886,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0030496,GO:0031902,GO:0036258,GO:0039702,GO:0043657,GO:0048306,GO:0070062,GO:0075733,GO:1902188,GO:1903774 ESCRT I complex|cytoplasm|endosome|plasma membrane|endosome membrane|protein transport|endosomal transport|macroautophagy|viral life cycle|midbody|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|host cell|calcium-dependent protein binding|extracellular exosome|intracellular transport of virus|positive regulation of viral release from host cell|positive regulation of viral budding via host ESCRT complex hsa04144 Endocytosis VPS37C 450.966349647651 455.094691622173 446.838007673128 0.981857217627361 -0.0264148528299964 0.897615488409454 1 6.13149 5.77499 6.62074 6.04173 GeneID:55048,Genbank:NM_017966.4,HGNC:HGNC:26097,MIM:610038 VPS37C, ESCRT-I subunit GO:0000813,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0036258,GO:0039702,GO:0043657,GO:0046983,GO:0048306,GO:0070062,GO:0075733 ESCRT I complex|endosome membrane|protein transport|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|host cell|protein dimerization activity|calcium-dependent protein binding|extracellular exosome|intracellular transport of virus hsa04144 Endocytosis VPS37D 52.1200162275228 51.9083339870486 52.3316984679969 1.00815600209889 0.0117188987985206 1 1 1.13872 1.52386 1.24599 1.61478 GeneID:155382,Genbank:XM_017011779.1,HGNC:HGNC:18287,MIM:610039 VPS37D, ESCRT-I subunit GO:0000813,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0031902,GO:0036258,GO:0039702,GO:0043657,GO:0070062,GO:0075733 ESCRT I complex|endosome membrane|protein transport|endosomal transport|macroautophagy|viral life cycle|late endosome membrane|multivesicular body assembly|viral budding via host ESCRT complex|host cell|extracellular exosome|intracellular transport of virus hsa04144 Endocytosis VPS39 2016.6812772867 1842.81822377596 2190.54433079744 1.18869257018144 0.249375641219692 0.0791482577729714 0.945390555851746 9.79431 10.7 12.7797 11.6799 GeneID:23339,Genbank:XM_011521404.2,HGNC:HGNC:20593,MIM:612188 VPS39, HOPS complex subunit GO:0005765,GO:0006886,GO:0006914,GO:0008333,GO:0030123,GO:0030897,GO:0031902,GO:0034058,GO:1902774,GO:1990126 lysosomal membrane|intracellular protein transport|autophagy|endosome to lysosome transport|AP-3 adaptor complex|HOPS complex|late endosome membrane|endosomal vesicle fusion|late endosome to lysosome transport|retrograde transport, endosome to plasma membrane VPS41 1498.73850414237 1444.59615574189 1552.88085254285 1.07495845560059 0.104280904412711 0.494622186276597 1 9.29748 8.3762 10.955 8.54855 GeneID:27072,Genbank:NM_080631.3,HGNC:HGNC:12713,MIM:605485 VPS41, HOPS complex subunit GO:0005765,GO:0005769,GO:0005794,GO:0005798,GO:0005829,GO:0006623,GO:0006914,GO:0008017,GO:0008333,GO:0010008,GO:0015630,GO:0016020,GO:0030123,GO:0030136,GO:0030897,GO:0031902,GO:0033263,GO:0034058,GO:0035542,GO:0042144,GO:0042802,GO:0043621,GO:0045055,GO:0046872,GO:0048193,GO:0051020,GO:1902774 lysosomal membrane|early endosome|Golgi apparatus|Golgi-associated vesicle|cytosol|protein targeting to vacuole|autophagy|microtubule binding|endosome to lysosome transport|endosome membrane|microtubule cytoskeleton|membrane|AP-3 adaptor complex|clathrin-coated vesicle|HOPS complex|late endosome membrane|CORVET complex|endosomal vesicle fusion|regulation of SNARE complex assembly|vacuole fusion, non-autophagic|identical protein binding|protein self-association|regulated exocytosis|metal ion binding|Golgi vesicle transport|GTPase binding|late endosome to lysosome transport VPS45 630.718312868187 602.333575270026 659.103050466348 1.0942492292097 0.129941367741423 0.412035103176579 1 6.6313 5.25839 7.08547 6.60864 GeneID:11311,Genbank:XM_024452791.1,HGNC:HGNC:14579,MIM:610035 vacuolar protein sorting 45 homolog GO:0000139,GO:0005794,GO:0006886,GO:0006904,GO:0007596,GO:0010008,GO:0016021 Golgi membrane|Golgi apparatus|intracellular protein transport|vesicle docking involved in exocytosis|blood coagulation|endosome membrane|integral component of membrane hsa04144 Endocytosis VPS4A 3208.7706618112 3004.90227362468 3412.63904999771 1.13569052809201 0.183569758775071 0.186673403387962 1 42.824 47.2178 51.109 52.1623 GeneID:27183,Genbank:NM_013245.2,HGNC:HGNC:13488,MIM:609982 vacuolar protein sorting 4 homolog A GO:0000916,GO:0000920,GO:0000922,GO:0005524,GO:0005634,GO:0005737,GO:0005764,GO:0005768,GO:0005769,GO:0005770,GO:0005774,GO:0005813,GO:0005829,GO:0005886,GO:0006622,GO:0006900,GO:0006997,GO:0006998,GO:0007080,GO:0008022,GO:0009838,GO:0016192,GO:0016197,GO:0016236,GO:0016887,GO:0019058,GO:0019076,GO:0019904,GO:0030496,GO:0031468,GO:0031902,GO:0032367,GO:0032466,GO:0032880,GO:0034058,GO:0036258,GO:0039702,GO:0042623,GO:0043162,GO:0044878,GO:0048471,GO:0051301,GO:0061640,GO:0061738,GO:0070062,GO:0072319,GO:0090543,GO:0090611,GO:1902188,GO:1903076,GO:1903543,GO:1903774,GO:1903902,GO:1904896,GO:1904903 actomyosin contractile ring contraction|cell separation after cytokinesis|spindle pole|ATP binding|nucleus|cytoplasm|lysosome|endosome|early endosome|late endosome|vacuolar membrane|centrosome|cytosol|plasma membrane|protein targeting to lysosome|vesicle budding from membrane|nucleus organization|nuclear envelope organization|mitotic metaphase plate congression|protein C-terminus binding|abscission|vesicle-mediated transport|endosomal transport|macroautophagy|ATPase activity|viral life cycle|viral release from host cell|protein domain specific binding|midbody|nuclear envelope reassembly|late endosome membrane|intracellular cholesterol transport|negative regulation of cytokinesis|regulation of protein localization|endosomal vesicle fusion|multivesicular body assembly|viral budding via host ESCRT complex|ATPase activity, coupled|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|mitotic cytokinesis checkpoint|perinuclear region of cytoplasm|cell division|cytoskeleton-dependent cytokinesis|late endosomal microautophagy|extracellular exosome|vesicle uncoating|Flemming body|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|positive regulation of viral release from host cell|regulation of protein localization to plasma membrane|positive regulation of exosomal secretion|positive regulation of viral budding via host ESCRT complex|positive regulation of viral life cycle|ESCRT complex disassembly|ESCRT III complex disassembly hsa04144,hsa04217 Endocytosis|Necroptosis VPS4B 487.960173105965 549.426498169701 426.493848042229 0.776252782606962 -0.365401559965105 0.0394933977275931 0.756156754175857 6.03518 5.60349 4.86617 4.30949 GeneID:9525,Genbank:NM_004869.3,HGNC:HGNC:10895,MIM:609983 vacuolar protein sorting 4 homolog B GO:0000920,GO:0000922,GO:0005524,GO:0005634,GO:0005737,GO:0005768,GO:0005813,GO:0005829,GO:0006813,GO:0006997,GO:0007080,GO:0008022,GO:0010008,GO:0010824,GO:0010971,GO:0015031,GO:0016197,GO:0016236,GO:0016887,GO:0019058,GO:0019076,GO:0030301,GO:0031902,GO:0032510,GO:0033993,GO:0036258,GO:0039702,GO:0042623,GO:0042802,GO:0042803,GO:0043162,GO:0048524,GO:0050792,GO:0051261,GO:0060548,GO:0061738,GO:0070062,GO:0090543,GO:0090611,GO:1901673,GO:1902188,GO:1903542,GO:1903543,GO:1903724,GO:1903902,GO:1904903 cell separation after cytokinesis|spindle pole|ATP binding|nucleus|cytoplasm|endosome|centrosome|cytosol|potassium ion transport|nucleus organization|mitotic metaphase plate congression|protein C-terminus binding|endosome membrane|regulation of centrosome duplication|positive regulation of G2/M transition of mitotic cell cycle|protein transport|endosomal transport|macroautophagy|ATPase activity|viral life cycle|viral release from host cell|cholesterol transport|late endosome membrane|endosome to lysosome transport via multivesicular body sorting pathway|response to lipid|multivesicular body assembly|viral budding via host ESCRT complex|ATPase activity, coupled|identical protein binding|protein homodimerization activity|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|positive regulation of viral process|regulation of viral process|protein depolymerization|negative regulation of cell death|late endosomal microautophagy|extracellular exosome|Flemming body|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|regulation of mitotic spindle assembly|positive regulation of viral release from host cell|negative regulation of exosomal secretion|positive regulation of exosomal secretion|positive regulation of centriole elongation|positive regulation of viral life cycle|ESCRT III complex disassembly hsa04144,hsa04217 Endocytosis|Necroptosis VPS50 135.253949681839 143.049772094301 127.458127269377 0.891005454977971 -0.166493830541314 0.560740737395416 1 0.598206 0.471545 0.426739 0.439001 GeneID:55610,Genbank:NM_001257998.1,HGNC:HGNC:25956,MIM:616465 VPS50, EARP/GARPII complex subunit GO:0000149,GO:0015031,GO:0016020,GO:0032456,GO:0055037,GO:0070062,GO:1990745 SNARE binding|protein transport|membrane|endocytic recycling|recycling endosome|extracellular exosome|EARP complex VPS51 1171.75602576014 1105.86991744768 1237.64213407261 1.11915706770382 0.162412525050265 0.342841648063807 1 22.3068 22.6277 24.0993 27.3122 GeneID:738,Genbank:NM_013265.3,HGNC:HGNC:1172,MIM:615738 VPS51, GARP complex subunit GO:0000938,GO:0005730,GO:0005794,GO:0005829,GO:0006869,GO:0006914,GO:0007030,GO:0007041,GO:0015031,GO:0016020,GO:0016021,GO:0032456,GO:0032588,GO:0042147,GO:0043231,GO:0048193,GO:0055037,GO:1990745 GARP complex|nucleolus|Golgi apparatus|cytosol|lipid transport|autophagy|Golgi organization|lysosomal transport|protein transport|membrane|integral component of membrane|endocytic recycling|trans-Golgi network membrane|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|Golgi vesicle transport|recycling endosome|EARP complex VPS52 2032.03234246097 1889.60329567852 2174.46138924342 1.15075020996013 0.202574705788752 0.148499701829079 1 13.1046 13.4209 15.9018 15.5312 GeneID:6293,Genbank:NM_001289176.1,HGNC:HGNC:10518,MIM:603443 VPS52, GARP complex subunit GO:0000938,GO:0005794,GO:0005829,GO:0006896,GO:0007041,GO:0010008,GO:0010668,GO:0015031,GO:0016020,GO:0017137,GO:0019905,GO:0032456,GO:0032588,GO:0042147,GO:0048471,GO:0048611,GO:0055037,GO:1990745 GARP complex|Golgi apparatus|cytosol|Golgi to vacuole transport|lysosomal transport|endosome membrane|ectodermal cell differentiation|protein transport|membrane|Rab GTPase binding|syntaxin binding|endocytic recycling|trans-Golgi network membrane|retrograde transport, endosome to Golgi|perinuclear region of cytoplasm|embryonic ectodermal digestive tract development|recycling endosome|EARP complex VPS53 1301.20747208897 1170.35437774964 1432.0605664283 1.22361277374966 0.291147072918448 0.0457655749527979 0.79332376136203 2.59082 2.37884 3.12213 2.98857 GeneID:55275,Genbank:NM_001128159.2,HGNC:HGNC:25608,MIM:615850 VPS53, GARP complex subunit GO:0000938,GO:0005794,GO:0005802,GO:0005829,GO:0007041,GO:0010008,GO:0015031,GO:0016020,GO:0032456,GO:0042147,GO:0048471,GO:0055037,GO:1990745 GARP complex|Golgi apparatus|trans-Golgi network|cytosol|lysosomal transport|endosome membrane|protein transport|membrane|endocytic recycling|retrograde transport, endosome to Golgi|perinuclear region of cytoplasm|recycling endosome|EARP complex VPS54 285.79219134274 305.49067785794 266.093704827541 0.871037069587049 -0.199193976555319 0.470515399237674 1 2.83069 2.27092 2.68966 1.72417 GeneID:51542,Genbank:NM_001005739.1,HGNC:HGNC:18652,MIM:614633 VPS54, GARP complex subunit GO:0000938,GO:0005654,GO:0005794,GO:0005802,GO:0005829,GO:0006896,GO:0007041,GO:0015031,GO:0019905,GO:0032588,GO:0040007,GO:0042147,GO:0048471,GO:0048873,GO:0050881,GO:0060052 GARP complex|nucleoplasm|Golgi apparatus|trans-Golgi network|cytosol|Golgi to vacuole transport|lysosomal transport|protein transport|syntaxin binding|trans-Golgi network membrane|growth|retrograde transport, endosome to Golgi|perinuclear region of cytoplasm|homeostasis of number of cells within a tissue|musculoskeletal movement|neurofilament cytoskeleton organization VPS72 1453.30327381687 1464.44219419618 1442.16435343756 0.98478749052239 -0.0221156590966088 0.861809489469276 1 28.9692 31.3928 29.2048 32.5561 GeneID:6944,Genbank:NM_001271088.1,HGNC:HGNC:11644,MIM:600607 vacuolar protein sorting 72 homolog GO:0000122,GO:0003677,GO:0005634,GO:0005654,GO:0006351,GO:0016569,GO:0016607,GO:0035019,GO:0042393,GO:0043234,GO:0043486 negative regulation of transcription from RNA polymerase II promoter|DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|covalent chromatin modification|nuclear speck|somatic stem cell population maintenance|histone binding|protein complex|histone exchange VPS8 1029.99045363141 1039.27702471041 1020.70388255241 0.982128785957547 -0.0260158782089931 0.885888234860519 1 4.19456 3.89607 4.36329 3.68562 GeneID:23355,Genbank:NM_001349294.1,HGNC:HGNC:29122 VPS8, CORVET complex subunit GO:0005769,GO:0015031,GO:0033263,GO:0034058,GO:0046872 early endosome|protein transport|CORVET complex|endosomal vesicle fusion|metal ion binding VPS9D1 371.818016316301 327.823256939878 415.812775692724 1.26840535834523 0.343015877194689 0.0718835327052496 0.928200388965456 2.66786 3.12849 3.87872 3.4909 GeneID:9605,Genbank:XM_006721350.3,HGNC:HGNC:13526 VPS9 domain containing 1 GO:0005096,GO:0005215,GO:0015986 GTPase activator activity|transporter activity|ATP synthesis coupled proton transport VRK1 284.64179276208 303.694088384381 265.589497139779 0.87452969056028 -0.193420729954903 0.356379392536341 1 3.39854 3.15967 2.97748 2.61183 GeneID:7443,Genbank:NM_003384.2,HGNC:HGNC:12718,MIM:602168 vaccinia related kinase 1 VRK2 20.7801986740895 22.1776746019202 19.3827227462587 0.873974530430725 -0.194336857903702 0.799198310572702 1 0.0471197 0.0613919 0.050689 0.0707333 GeneID:7444,Genbank:NM_001288837.1,HGNC:HGNC:12719,MIM:602169 vaccinia related kinase 2 VRK3 739.434368938585 714.636361557416 764.232376319754 1.06940035160575 0.0968020561897225 0.561580729243926 1 6.4601 7.05186 7.54515 8.04359 GeneID:51231,Genbank:NM_001025778.1,HGNC:HGNC:18996 vaccinia related kinase 3 GO:0004674,GO:0005524,GO:0005634,GO:0005730,GO:0005737,GO:0008360,GO:0018105,GO:0019903,GO:0032516,GO:0043231,GO:0070373 protein serine/threonine kinase activity|ATP binding|nucleus|nucleolus|cytoplasm|regulation of cell shape|peptidyl-serine phosphorylation|protein phosphatase binding|positive regulation of phosphoprotein phosphatase activity|intracellular membrane-bounded organelle|negative regulation of ERK1 and ERK2 cascade VSIG1 0.730104003565851 0.490071401957362 0.97013660517434 1.97958216149643 0.985195946894947 1 1 0 0.0108433 0.0220949 0 GeneID:340547,Genbank:XM_011530936.2,HGNC:HGNC:28675,MIM:300620 V-set and immunoglobulin domain containing 1 GO:0003382,GO:0005886,GO:0016021,GO:0030277 epithelial cell morphogenesis|plasma membrane|integral component of membrane|maintenance of gastrointestinal epithelium VSIG10 353.74219167582 408.471281852177 299.013101499464 0.732029679402711 -0.450025952581482 0.0193691834856082 0.567967248609484 2.53355 2.27096 1.78435 1.87673 GeneID:54621,Genbank:XM_017019505.1,HGNC:HGNC:26078 V-set and immunoglobulin domain containing 10 GO:0016021 integral component of membrane VSIG10L 88.7243787422662 71.3092763114954 106.139481173037 1.48843862486271 0.573799733882463 0.139508447030672 1 0.622419 0.974487 1.4152 0.997272 GeneID:147645,Genbank:NM_001163922.2,HGNC:HGNC:27111,MIM:617740 V-set and immunoglobulin domain containing 10 like GO:0005634,GO:0005654,GO:0016021 nucleus|nucleoplasm|integral component of membrane VSIG2 2.24247141269929 2.54640955915669 1.93853326624189 0.76128101988585 -0.393498985236256 0.964560642378451 1 0.0329219 0.0289715 0.0307173 0 GeneID:23584,Genbank:NM_014312.4,HGNC:HGNC:17149,MIM:606011 V-set and immunoglobulin domain containing 2 GO:0005887,GO:0016020 integral component of plasma membrane|membrane VSIG8 3.0015916529778 4.06465003971372 1.93853326624189 0.476925011329738 -1.06816565106221 0.612697794767789 1 0 0.0251418 0.0270297 0 GeneID:391123,Genbank:NM_001013661.1,HGNC:HGNC:32063 V-set and immunoglobulin domain containing 8 GO:0003723,GO:0016021 RNA binding|integral component of membrane VSIR 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0100256 0 0 0 GeneID:64115,Genbank:NM_022153.1,HGNC:HGNC:30085,MIM:615608 V-set immunoregulatory receptor GO:0005886,GO:0016021,GO:0042802 plasma membrane|integral component of membrane|identical protein binding VSNL1 104.929508257916 110.51397146723 99.345045048603 0.898936521144401 -0.153708852188356 0.599736116080482 1 1.92043 2.1984 1.79151 1.99399 GeneID:7447,Genbank:NM_003385.4,HGNC:HGNC:12722,MIM:600817 visinin like 1 GO:0005509,GO:0005829,GO:0007417,GO:0016020,GO:0019722,GO:0035774,GO:0045921,GO:0046676 calcium ion binding|cytosol|central nervous system development|membrane|calcium-mediated signaling|positive regulation of insulin secretion involved in cellular response to glucose stimulus|positive regulation of exocytosis|negative regulation of insulin secretion VSTM1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:284415,Genbank:XM_011526849.1,HGNC:HGNC:29455,MIM:616804 V-set and transmembrane domain containing 1 GO:0002376,GO:0005125,GO:0005615,GO:0016021 immune system process|cytokine activity|extracellular space|integral component of membrane VSTM2L 124.617860156293 127.118564203987 122.117156108598 0.960655564930994 -0.0579088374967111 0.825502240060785 1 2.63879 3.18762 2.73548 3.05917 GeneID:128434,Genbank:NM_080607.2,HGNC:HGNC:16096,MIM:616537 V-set and transmembrane domain containing 2 like GO:0005576,GO:0005737,GO:0043524 extracellular region|cytoplasm|negative regulation of neuron apoptotic process VSX1 2.95856847766305 4.94874029425856 0.968396661067546 0.195685488323374 -2.35339132257195 0.372442221121264 1 0.00953632 0.0526452 0 0.0168123 GeneID:30813,Genbank:XM_017027838.1,HGNC:HGNC:12723,MIM:605020 visual system homeobox 1 GO:0003682,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0007601,GO:0042551,GO:0043565,GO:0044212,GO:0048666,GO:0050896,GO:0060040 chromatin binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|visual perception|neuron maturation|sequence-specific DNA binding|transcription regulatory region DNA binding|neuron development|response to stimulus|retinal bipolar neuron differentiation VTA1 910.509756942996 986.436574194137 834.582939691855 0.846058389890564 -0.241170861921973 0.126852089149228 1 13.1139 12.0078 11.8931 9.56737 GeneID:51534,Genbank:NM_016485.4,HGNC:HGNC:20954,MIM:610902 vesicle trafficking 1 GO:0005654,GO:0005829,GO:0008022,GO:0010008,GO:0015031,GO:0016197,GO:0016236,GO:0019058,GO:0036258,GO:0043231,GO:0046755,GO:0070062,GO:0071985,GO:1904903 nucleoplasm|cytosol|protein C-terminus binding|endosome membrane|protein transport|endosomal transport|macroautophagy|viral life cycle|multivesicular body assembly|intracellular membrane-bounded organelle|viral budding|extracellular exosome|multivesicular body sorting pathway|ESCRT III complex disassembly hsa04144 Endocytosis VTCN1 6.37958294427232 5.97690937285823 6.78225651568641 1.13474307415223 0.182365682885431 0.980217124246664 1 0 0.0940835 0.0320125 0.0893365 GeneID:79679,Genbank:XM_017002335.2,HGNC:HGNC:28873,MIM:608162 V-set domain containing T cell activation inhibitor 1 hsa04514 Cell adhesion molecules (CAMs) VTI1A 821.211703480257 828.214205949374 814.209201011141 0.983090117462813 -0.0246044239394367 0.896099787937408 1 1.12251 1.01129 1.11208 0.998677 GeneID:143187,Genbank:NM_001318203.1,HGNC:HGNC:17792,MIM:614316 vesicle transport through interaction with t-SNAREs 1A GO:0000139,GO:0000149,GO:0005484,GO:0005768,GO:0005776,GO:0005789,GO:0005794,GO:0005829,GO:0006623,GO:0006888,GO:0006891,GO:0006896,GO:0006914,GO:0008021,GO:0012507,GO:0016021,GO:0030136,GO:0031201,GO:0031902,GO:0032588,GO:0042147,GO:0043025,GO:0043231,GO:0044306,GO:0048280,GO:0048471,GO:0050882,GO:0090161 Golgi membrane|SNARE binding|SNAP receptor activity|endosome|autophagosome|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein targeting to vacuole|ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi to vacuole transport|autophagy|synaptic vesicle|ER to Golgi transport vesicle membrane|integral component of membrane|clathrin-coated vesicle|SNARE complex|late endosome membrane|trans-Golgi network membrane|retrograde transport, endosome to Golgi|neuronal cell body|intracellular membrane-bounded organelle|neuron projection terminus|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|voluntary musculoskeletal movement|Golgi ribbon formation hsa04130 SNARE interactions in vesicular transport VTI1B 1287.54210984859 1340.2924673684 1234.79175232877 0.921285303313853 -0.118280096077252 0.414198482887311 1 36.4128 39.4942 33.9933 35.9018 GeneID:10490,Genbank:NM_006370.2,HGNC:HGNC:17793,MIM:603207 vesicle transport through interaction with t-SNAREs 1B GO:0000149,GO:0002576,GO:0005484,GO:0005576,GO:0005765,GO:0005789,GO:0005794,GO:0005829,GO:0006623,GO:0006888,GO:0006891,GO:0006896,GO:0006904,GO:0008021,GO:0008283,GO:0012507,GO:0016021,GO:0016192,GO:0019869,GO:0031093,GO:0031201,GO:0031901,GO:0031902,GO:0031982,GO:0042147,GO:0043025,GO:0043231,GO:0048280,GO:0048471,GO:0055037,GO:0055038,GO:0061025,GO:1903076 SNARE binding|platelet degranulation|SNAP receptor activity|extracellular region|lysosomal membrane|endoplasmic reticulum membrane|Golgi apparatus|cytosol|protein targeting to vacuole|ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|Golgi to vacuole transport|vesicle docking involved in exocytosis|synaptic vesicle|cell proliferation|ER to Golgi transport vesicle membrane|integral component of membrane|vesicle-mediated transport|chloride channel inhibitor activity|platelet alpha granule lumen|SNARE complex|early endosome membrane|late endosome membrane|vesicle|retrograde transport, endosome to Golgi|neuronal cell body|intracellular membrane-bounded organelle|vesicle fusion with Golgi apparatus|perinuclear region of cytoplasm|recycling endosome|recycling endosome membrane|membrane fusion|regulation of protein localization to plasma membrane hsa04130 SNARE interactions in vesicular transport VTN 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.046252 0 0 GeneID:7448,Genbank:NM_000638.3,HGNC:HGNC:12724,MIM:193190 vitronectin hsa04151,hsa04510,hsa04512,hsa04610,hsa05165,hsa05205 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Complement and coagulation cascades|Human papillomavirus infection|Proteoglycans in cancer VWA1 10.0481475677402 12.8281003451534 7.26819479032697 0.566583874055289 -0.819638554151831 0.387702401947039 1 0.151989 0.138184 0.0695362 0.0977897 GeneID:64856,Genbank:NM_022834.4,HGNC:HGNC:30910,MIM:611901 von Willebrand factor A domain containing 1 GO:0005604,GO:0005614,GO:0005615,GO:0005788,GO:0030198,GO:0031012,GO:0042802,GO:0043687,GO:0044267,GO:0048266,GO:0070062 basement membrane|interstitial matrix|extracellular space|endoplasmic reticulum lumen|extracellular matrix organization|extracellular matrix|identical protein binding|post-translational protein modification|cellular protein metabolic process|behavioral response to pain|extracellular exosome VWA2 4.77713482900881 5.67894306964064 3.87532658837698 0.682402788838348 -0.551304552224371 0.757288525872132 1 0.0313107 0.0286127 0.0148093 0.034541 GeneID:340706,Genbank:NM_001272046.1,HGNC:HGNC:24709 von Willebrand factor A domain containing 2 GO:0005509,GO:0005604,GO:0005615,GO:0007161,GO:0042802,GO:0046626,GO:0051260,GO:0070062 calcium ion binding|basement membrane|extracellular space|calcium-independent cell-matrix adhesion|identical protein binding|regulation of insulin receptor signaling pathway|protein homooligomerization|extracellular exosome VWA3A 0.972203168832738 0.490071401957362 1.45433493570811 2.96759804775273 1.56929569647876 0.837430708298891 1 0 0 0 0 GeneID:146177,Genbank:XM_011545742.3,HGNC:HGNC:27088 von Willebrand factor A domain containing 3A GO:0005576 extracellular region VWA3B 0.727602453880755 0 1.45520490776151 Inf Inf 0.598539098462738 1 0 0 0.00629741 0 GeneID:200403,Genbank:NM_144992.4,HGNC:HGNC:28385,MIM:614884 von Willebrand factor A domain containing 3B GO:0005737 cytoplasm VWA5A 47.3679491453475 43.3752063999258 51.3606918907692 1.18410253584078 0.243794014703351 0.555934724202302 1 0.387394 0.272297 0.323802 0.500622 GeneID:4013,Genbank:NM_001130142.1,HGNC:HGNC:6658,MIM:602929 von Willebrand factor A domain containing 5A GO:0005634,GO:0005654 nucleus|nucleoplasm VWA5B2 43.2002123002838 41.8089396446838 44.5914849558838 1.06655383597019 0.0929567898012752 0.840059501113463 1 0.516977 0.2581 0.494799 0.320188 GeneID:90113,Genbank:XM_011513291.2,HGNC:HGNC:25144 von Willebrand factor A domain containing 5B2 VWA7 16.6321121999064 15.8165550315825 17.4476693682304 1.10312702945685 0.141598932556863 0.891909852567853 1 0.0679832 0.12846 0.117555 0.101674 GeneID:80737,Genbank:XM_005249427.2,HGNC:HGNC:13939,MIM:609693 von Willebrand factor A domain containing 7 GO:0005576 extracellular region VWA8 274.446099388266 295.420709480899 253.471489295634 0.858001762100645 -0.220947484258985 0.294861722498133 1 0.848041 0.712553 0.677256 0.646012 GeneID:23078,Genbank:NM_015058.1,HGNC:HGNC:29071,MIM:617509 von Willebrand factor A domain containing 8 GO:0005524,GO:0005739,GO:0016887 ATP binding|mitochondrion|ATPase activity VWCE 10.6982725241966 11.7038787171838 9.69266633120943 0.828158473393826 -0.272021231869038 0.792892896242005 1 0.09735 0.131197 0.102668 0.108343 GeneID:220001,Genbank:XM_017017341.1,HGNC:HGNC:26487,MIM:611115 von Willebrand factor C and EGF domains GO:0005509,GO:0005576,GO:0005737,GO:0098586 calcium ion binding|extracellular region|cytoplasm|cellular response to virus VWDE 28.5563008135948 25.1181030136644 31.9944986135251 1.27376253676959 0.349096345917142 0.529587659541608 1 0.0820895 0.0789579 0.154412 0.0613841 GeneID:221806,Genbank:NM_001346973.1,HGNC:HGNC:21897 von Willebrand factor D and EGF domains GO:0005576 extracellular region VWF 51.6264538225666 50.4283111260686 52.8245965190647 1.04751865250862 0.0669759333204235 0.882328415504213 1 0.215077 0.156649 0.19092 0.204207 GeneID:7450,Genbank:NM_000552.4,HGNC:HGNC:12726,MIM:613160 von Willebrand factor hsa04151,hsa04510,hsa04512,hsa04610,hsa04611,hsa05165 PI3K-Akt signaling pathway|Focal adhesion|ECM-receptor interaction|Complement and coagulation cascades|Platelet activation|Human papillomavirus infection WAC 1442.92514792169 1466.25534997739 1419.594945866 0.968177163607891 -0.0466570291312625 0.769816715131648 1 10.5732 9.72597 10.8135 8.57974 GeneID:51322,Genbank:NM_100264.2,HGNC:HGNC:17327,MIM:615049 WW domain containing adaptor with coiled-coil GO:0000993,GO:0003682,GO:0005634,GO:0005654,GO:0005681,GO:0006351,GO:0006974,GO:0010390,GO:0016239,GO:0016567,GO:0016607,GO:0032435,GO:0044783,GO:0045893,GO:0071894 RNA polymerase II core binding|chromatin binding|nucleus|nucleoplasm|spliceosomal complex|transcription, DNA-templated|cellular response to DNA damage stimulus|histone monoubiquitination|positive regulation of macroautophagy|protein ubiquitination|nuclear speck|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|G1 DNA damage checkpoint|positive regulation of transcription, DNA-templated|histone H2B conserved C-terminal lysine ubiquitination WAPL 1096.14594511459 1171.51579999633 1020.77609023284 0.871329341214212 -0.198709969484886 0.458489439794915 1 5.64086 4.85577 5.48049 3.68139 GeneID:23063,Genbank:XM_017015979.1,HGNC:HGNC:23293,MIM:610754 WAPL cohesin release factor GO:0000775,GO:0000785,GO:0000795,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0005829,GO:0007062,GO:0007064,GO:0008156,GO:0008278,GO:0009636,GO:0016032,GO:0035562,GO:0045132,GO:0045875,GO:0048146,GO:0051301,GO:0060623,GO:0071168,GO:0071922 chromosome, centromeric region|chromatin|synaptonemal complex|nucleus|nucleoplasm|chromosome|cytoplasm|cytosol|sister chromatid cohesion|mitotic sister chromatid cohesion|negative regulation of DNA replication|cohesin complex|response to toxic substance|viral process|negative regulation of chromatin binding|meiotic chromosome segregation|negative regulation of sister chromatid cohesion|positive regulation of fibroblast proliferation|cell division|regulation of chromosome condensation|protein localization to chromatin|regulation of cohesin loading WARS 3184.38648066699 3058.28757947015 3310.48538186383 1.08246373038515 0.114318686041979 0.404400372021083 1 31.1469 32.4826 35.1608 34.2142 GeneID:7453,Genbank:NM_213645.1,HGNC:HGNC:12729,MIM:191050 tryptophanyl-tRNA synthetase GO:0001525,GO:0001933,GO:0004830,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0006412,GO:0006418,GO:0006436,GO:0006469,GO:0008285,GO:0010628,GO:0010835,GO:0019210,GO:0019901,GO:0019904,GO:0031334,GO:0042803,GO:0043234,GO:0045765,GO:0070062 angiogenesis|negative regulation of protein phosphorylation|tryptophan-tRNA ligase activity|ATP binding|nucleus|cytoplasm|cytosol|translation|tRNA aminoacylation for protein translation|tryptophanyl-tRNA aminoacylation|negative regulation of protein kinase activity|negative regulation of cell proliferation|positive regulation of gene expression|regulation of protein ADP-ribosylation|kinase inhibitor activity|protein kinase binding|protein domain specific binding|positive regulation of protein complex assembly|protein homodimerization activity|protein complex|regulation of angiogenesis|extracellular exosome hsa00970 Aminoacyl-tRNA biosynthesis WARS2 557.740551985902 627.441869628582 488.039234343222 0.777823823953795 -0.362484671154558 0.0499299203672031 0.815166074133459 6.3392 5.33244 5.13004 4.30962 GeneID:10352,Genbank:XM_017000041.2,HGNC:HGNC:12730,MIM:604733 tryptophanyl tRNA synthetase 2, mitochondrial GO:0001570,GO:0004830,GO:0005524,GO:0005739,GO:0005759,GO:0005886,GO:0006418,GO:0006436 vasculogenesis|tryptophan-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|plasma membrane|tRNA aminoacylation for protein translation|tryptophanyl-tRNA aminoacylation hsa00970 Aminoacyl-tRNA biosynthesis WAS 4.16580114873409 3.96859749034384 4.36300480712434 1.09938204056727 0.136692816909475 1 1 0.0173417 0.0752466 0.0639404 0.030054 GeneID:7454,Genbank:XM_017029786.1,HGNC:HGNC:12731,MIM:300392 Wiskott-Aldrich syndrome hsa04062,hsa04144,hsa04520,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05231 Chemokine signaling pathway|Endocytosis|Adherens junction|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Choline metabolism in cancer WASF1 693.86106809963 745.998897280977 641.723238918283 0.860220090481689 -0.217222268999089 0.260676857888981 1 9.34034 8.40773 9.24195 6.66795 GeneID:8936,Genbank:NM_001024936.1,HGNC:HGNC:12732,MIM:605035 WAS protein family member 1 GO:0003779,GO:0005741,GO:0005856,GO:0005925,GO:0006461,GO:0006898,GO:0006928,GO:0015629,GO:0016601,GO:0030027,GO:0030041,GO:0031209,GO:0032403,GO:0043234,GO:0045202,GO:0051018,GO:0051388,GO:0072673,GO:0097484,GO:1990416,GO:2000601 actin binding|mitochondrial outer membrane|cytoskeleton|focal adhesion|protein complex assembly|receptor-mediated endocytosis|movement of cell or subcellular component|actin cytoskeleton|Rac protein signal transduction|lamellipodium|actin filament polymerization|SCAR complex|protein complex binding|protein complex|synapse|protein kinase A binding|positive regulation of neurotrophin TRK receptor signaling pathway|lamellipodium morphogenesis|dendrite extension|cellular response to brain-derived neurotrophic factor stimulus|positive regulation of Arp2/3 complex-mediated actin nucleation hsa04520,hsa04666,hsa04810,hsa05100,hsa05131,hsa05132,hsa05231 Adherens junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection|Choline metabolism in cancer WASF2 3619.84509342904 3845.49069213512 3394.19949472297 0.882644054155393 -0.180096338593878 0.180766162008799 1 27.007 27.3162 23.6073 24.6657 GeneID:10163,Genbank:NM_001201404.2,HGNC:HGNC:12733,MIM:605875 WAS protein family member 2 GO:0001525,GO:0001667,GO:0001726,GO:0003779,GO:0005622,GO:0005769,GO:0005829,GO:0005911,GO:0007188,GO:0010592,GO:0015629,GO:0016032,GO:0016601,GO:0017124,GO:0030027,GO:0030032,GO:0030036,GO:0030048,GO:0031209,GO:0032403,GO:0035855,GO:0038096,GO:0043234,GO:0045296,GO:0048010,GO:0051018,GO:0051497,GO:0070062,GO:0072673 angiogenesis|ameboidal-type cell migration|ruffle|actin binding|intracellular|early endosome|cytosol|cell-cell junction|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|positive regulation of lamellipodium assembly|actin cytoskeleton|viral process|Rac protein signal transduction|SH3 domain binding|lamellipodium|lamellipodium assembly|actin cytoskeleton organization|actin filament-based movement|SCAR complex|protein complex binding|megakaryocyte development|Fc-gamma receptor signaling pathway involved in phagocytosis|protein complex|cadherin binding|vascular endothelial growth factor receptor signaling pathway|protein kinase A binding|negative regulation of stress fiber assembly|extracellular exosome|lamellipodium morphogenesis hsa04520,hsa04666,hsa04810,hsa05100,hsa05131,hsa05132,hsa05231 Adherens junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Shigellosis|Salmonella infection|Choline metabolism in cancer WASF3 420.213108073996 502.612000301821 337.81421584617 0.672117290560733 -0.57321507654892 0.00159408239699354 0.141054274421263 3.42563 3.68702 2.5761 2.13455 GeneID:10810,Genbank:XM_024449315.1,HGNC:HGNC:12734,MIM:605068 WAS protein family member 3 GO:0003779,GO:0005737,GO:0005856,GO:0006461,GO:0007010,GO:0008360,GO:0014003,GO:0030027,GO:0030032,GO:0030041,GO:0031643,GO:0070062 actin binding|cytoplasm|cytoskeleton|protein complex assembly|cytoskeleton organization|regulation of cell shape|oligodendrocyte development|lamellipodium|lamellipodium assembly|actin filament polymerization|positive regulation of myelination|extracellular exosome hsa04520,hsa04666,hsa05231 Adherens junction|Fc gamma R-mediated phagocytosis|Choline metabolism in cancer WASHC1 215.447657314731 226.860773483263 204.034541146199 0.899382198224111 -0.152993766348484 0.479636669230429 1 0.62382 0.731253 0.661772 0.618218 GeneID:100287171,Genbank:XM_011517666.2,HGNC:HGNC:24361,MIM:613632 WASH complex subunit 1 GO:0003779,GO:0005769,GO:0005770,GO:0005776,GO:0005814,GO:0005829,GO:0006887,GO:0010507,GO:0015031,GO:0016197,GO:0022617,GO:0030335,GO:0031274,GO:0031396,GO:0031625,GO:0031901,GO:0034314,GO:0042147,GO:0043014,GO:0043231,GO:0043553,GO:0055037,GO:0055038,GO:0071203,GO:0071437,GO:1990126 actin binding|early endosome|late endosome|autophagosome|centriole|cytosol|exocytosis|negative regulation of autophagy|protein transport|endosomal transport|extracellular matrix disassembly|positive regulation of cell migration|positive regulation of pseudopodium assembly|regulation of protein ubiquitination|ubiquitin protein ligase binding|early endosome membrane|Arp2/3 complex-mediated actin nucleation|retrograde transport, endosome to Golgi|alpha-tubulin binding|intracellular membrane-bounded organelle|negative regulation of phosphatidylinositol 3-kinase activity|recycling endosome|recycling endosome membrane|WASH complex|invadopodium|retrograde transport, endosome to plasma membrane hsa04144 Endocytosis WASHC2A 1552.72406135489 1593.82678496461 1511.62133774518 0.948422596486071 -0.0763980589653304 0.597488069906035 1 6.87419 6.91307 6.93451 6.35464 GeneID:387680,Genbank:NM_001005751.2,HGNC:HGNC:23416 WASH complex subunit 2A GO:0005730,GO:0005769,GO:0005829,GO:0005886,GO:0008289,GO:0015031,GO:0031901,GO:0042147,GO:0043231,GO:0071203 nucleolus|early endosome|cytosol|plasma membrane|lipid binding|protein transport|early endosome membrane|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|WASH complex hsa04144 Endocytosis WASHC2C 1182.16619368453 1220.10051237501 1144.23187499405 0.937817715334552 -0.0926205631266554 0.548317314306069 1 6.4979 6.22709 6.34803 5.74564 GeneID:253725,Genbank:NM_001330074.1,HGNC:HGNC:23414,MIM:613631 WASH complex subunit 2C GO:0005546,GO:0005547,GO:0005730,GO:0005768,GO:0005769,GO:0005829,GO:0005886,GO:0010314,GO:0015031,GO:0031901,GO:0032266,GO:0042147,GO:0043231,GO:0043325,GO:0070273,GO:0071203,GO:0080025,GO:1900024,GO:1905394,GO:1990126,GO:2000813 phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|nucleolus|endosome|early endosome|cytosol|plasma membrane|phosphatidylinositol-5-phosphate binding|protein transport|early endosome membrane|phosphatidylinositol-3-phosphate binding|retrograde transport, endosome to Golgi|intracellular membrane-bounded organelle|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4-phosphate binding|WASH complex|phosphatidylinositol-3,5-bisphosphate binding|regulation of substrate adhesion-dependent cell spreading|retromer complex binding|retrograde transport, endosome to plasma membrane|negative regulation of barbed-end actin filament capping hsa04144 Endocytosis WASHC3 274.83478404419 256.965834410763 292.703733677617 1.13907646263093 0.187864593890552 0.371044307663181 1 5.02952 5.42069 5.44226 6.2948 GeneID:51019,Genbank:NM_001301107.1,HGNC:HGNC:24256 WASH complex subunit 3 GO:0005769,GO:0015031,GO:0071203 early endosome|protein transport|WASH complex hsa04144 Endocytosis WASHC4 250.007007243009 246.961475616913 253.052538869105 1.02466402193693 0.0351509406152049 0.934931477179883 1 1.66204 1.14091 1.85871 0.779888 GeneID:23325,Genbank:NM_001293640.1,HGNC:HGNC:29174,MIM:615748 WASH complex subunit 4 GO:0005654,GO:0005768,GO:0005769,GO:0007032,GO:0015031,GO:0016197,GO:0071203 nucleoplasm|endosome|early endosome|endosome organization|protein transport|endosomal transport|WASH complex hsa04144 Endocytosis WASHC5 772.792146740725 773.067477247363 772.516816234086 0.999287693468572 -0.00102800727211247 0.985003840679565 1 4.35566 3.77897 4.50544 4.10308 GeneID:9897,Genbank:NM_001330609.1,HGNC:HGNC:28984,MIM:610657 WASH complex subunit 5 GO:0001556,GO:0005654,GO:0005769,GO:0005783,GO:0005829,GO:0010976,GO:0015031,GO:0016197,GO:0040038,GO:0043005,GO:0043025,GO:0071203,GO:0090306 oocyte maturation|nucleoplasm|early endosome|endoplasmic reticulum|cytosol|positive regulation of neuron projection development|protein transport|endosomal transport|polar body extrusion after meiotic divisions|neuron projection|neuronal cell body|WASH complex|spindle assembly involved in meiosis hsa04144 Endocytosis WASL 1006.44675178117 1047.87677888158 965.01672468076 0.920925765442325 -0.118843227544268 0.588697666171986 1 10.2695 9.18954 10.4181 7.587 GeneID:8976,Genbank:NM_003941.3,HGNC:HGNC:12735,MIM:605056 Wiskott-Aldrich syndrome like GO:0003779,GO:0005634,GO:0005829,GO:0005886,GO:0006351,GO:0006355,GO:0006461,GO:0006900,GO:0006928,GO:0008154,GO:0009617,GO:0015629,GO:0016050,GO:0030027,GO:0030050,GO:0030478,GO:0030666,GO:0030695,GO:0031410,GO:0032880,GO:0034629,GO:0038096,GO:0048013,GO:0050999,GO:0051301,GO:0051491,GO:0051653,GO:0060997,GO:0061024,GO:0070062,GO:1903526,GO:2000370,GO:2000402,GO:2000601 actin binding|nucleus|cytosol|plasma membrane|transcription, DNA-templated|regulation of transcription, DNA-templated|protein complex assembly|vesicle budding from membrane|movement of cell or subcellular component|actin polymerization or depolymerization|response to bacterium|actin cytoskeleton|vesicle organization|lamellipodium|vesicle transport along actin filament|actin cap|endocytic vesicle membrane|GTPase regulator activity|cytoplasmic vesicle|regulation of protein localization|cellular protein complex localization|Fc-gamma receptor signaling pathway involved in phagocytosis|ephrin receptor signaling pathway|regulation of nitric-oxide synthase activity|cell division|positive regulation of filopodium assembly|spindle localization|dendritic spine morphogenesis|membrane organization|extracellular exosome|negative regulation of membrane tubulation|positive regulation of clathrin-dependent endocytosis|negative regulation of lymphocyte migration|positive regulation of Arp2/3 complex-mediated actin nucleation hsa04062,hsa04144,hsa04520,hsa04530,hsa04666,hsa04810,hsa05100,hsa05130,hsa05131,hsa05132,hsa05231 Chemokine signaling pathway|Endocytosis|Adherens junction|Tight junction|Fc gamma R-mediated phagocytosis|Regulation of actin cytoskeleton|Bacterial invasion of epithelial cells|Pathogenic Escherichia coli infection|Shigellosis|Salmonella infection|Choline metabolism in cancer WBP1 904.897310257189 795.554960809319 1014.23965970506 1.27488320690411 0.350365086662111 0.0910443460965769 0.981269345277777 29.2403 32.9637 38.0911 42.8533 GeneID:23559,Genbank:NM_012477.3,HGNC:HGNC:12737,MIM:606961 WW domain binding protein 1 GO:0050699 WW domain binding WBP11 2167.80089386986 1999.18413361566 2336.41765412406 1.16868557269834 0.224886834296019 0.104206584582464 1 22.2035 21.1028 26.5111 24.2367 GeneID:51729,Genbank:NM_016312.2,HGNC:HGNC:16461 WW domain binding protein 11 GO:0000398,GO:0003697,GO:0003723,GO:0005634,GO:0005654,GO:0005681,GO:0005829,GO:0006364,GO:0043231,GO:0045292,GO:0050699,GO:1903146,GO:1903955 mRNA splicing, via spliceosome|single-stranded DNA binding|RNA binding|nucleus|nucleoplasm|spliceosomal complex|cytosol|rRNA processing|intracellular membrane-bounded organelle|mRNA cis splicing, via spliceosome|WW domain binding|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion hsa03040 Spliceosome WBP1L 2249.77590123897 2125.34318932681 2374.20861315114 1.11709422980444 0.159750886034077 0.254218374346069 1 12.8998 13.2793 15.1117 14.3784 GeneID:54838,Genbank:XM_017016360.1,HGNC:HGNC:23510,MIM:611129 WW domain binding protein 1 like GO:0016021 integral component of membrane WBP2 2514.90216126749 2618.8653640555 2410.93895847948 0.920604392868052 -0.119346768169759 0.381244505716878 1 39.8031 40.0201 36.9908 37.8877 GeneID:23558,Genbank:NM_001348170.1,HGNC:HGNC:12738,MIM:606962 WW domain binding protein 2 GO:0000790,GO:0000979,GO:0001105,GO:0003713,GO:0005634,GO:0005737,GO:0030331,GO:0031490,GO:0032570,GO:0033148,GO:0043627,GO:0045184,GO:0045815,GO:0045944,GO:0050847,GO:0071391,GO:0071442 nuclear chromatin|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II transcription coactivator activity|transcription coactivator activity|nucleus|cytoplasm|estrogen receptor binding|chromatin DNA binding|response to progesterone|positive regulation of intracellular estrogen receptor signaling pathway|response to estrogen|establishment of protein localization|positive regulation of gene expression, epigenetic|positive regulation of transcription from RNA polymerase II promoter|progesterone receptor signaling pathway|cellular response to estrogen stimulus|positive regulation of histone H3-K14 acetylation WBP4 145.757121143555 140.311257436404 151.202984850707 1.07762547078049 0.107855855889116 0.660110612338593 1 1.69982 1.36186 1.57531 1.57469 GeneID:11193,Genbank:NM_007187.4,HGNC:HGNC:12739,MIM:604981 WW domain binding protein 4 GO:0000398,GO:0003676,GO:0005654,GO:0005681,GO:0008270,GO:0016607,GO:0045292,GO:0070064 mRNA splicing, via spliceosome|nucleic acid binding|nucleoplasm|spliceosomal complex|zinc ion binding|nuclear speck|mRNA cis splicing, via spliceosome|proline-rich region binding WDCP 310.480591328384 319.048980978475 301.912201678293 0.946287935953825 -0.0796488620976868 0.753558082100843 1 3.83486 3.01272 3.10331 3.30642 GeneID:80304,Genbank:NM_001142319.1,HGNC:HGNC:26157,MIM:616234 WD repeat and coiled coil containing GO:0019900,GO:0051259 kinase binding|protein oligomerization WDFY1 764.99712904284 876.192160065656 653.802098020025 0.746185743057817 -0.422393299214415 0.00870721348858858 0.363163362586549 8.06838 7.45298 6.44491 5.29889 GeneID:57590,Genbank:NM_020830.4,HGNC:HGNC:20451 WD repeat and FYVE domain containing 1 GO:0005545,GO:0005634,GO:0005769,GO:0005829,GO:0008270,GO:0034141,GO:0034145 1-phosphatidylinositol binding|nucleus|early endosome|cytosol|zinc ion binding|positive regulation of toll-like receptor 3 signaling pathway|positive regulation of toll-like receptor 4 signaling pathway WDFY2 604.820223393775 539.817175229294 669.823271558256 1.24083356790888 0.311309620823042 0.110253325744708 1 1.58802 1.40801 2.17488 1.6408 GeneID:115825,Genbank:XM_024449316.1,HGNC:HGNC:20482,MIM:610418 WD repeat and FYVE domain containing 2 GO:0001934,GO:0005769,GO:0031982,GO:0045600,GO:0046872 positive regulation of protein phosphorylation|early endosome|vesicle|positive regulation of fat cell differentiation|metal ion binding WDFY3 1213.78901694914 1225.39422824632 1202.18380565196 0.981058811883284 -0.0275884700951286 0.957311659180075 1 2.8708 2.44133 3.57258 1.84347 GeneID:23001,Genbank:NM_014991.4,HGNC:HGNC:20751,MIM:617485 WD repeat and FYVE domain containing 3 GO:0003831,GO:0005545,GO:0005634,GO:0005635,GO:0005730,GO:0005737,GO:0005776,GO:0005829,GO:0005886,GO:0007275,GO:0016234,GO:0016605,GO:0019898,GO:0030424,GO:0031965,GO:0035973,GO:0043204,GO:0046872,GO:0097635 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity|1-phosphatidylinositol binding|nucleus|nuclear envelope|nucleolus|cytoplasm|autophagosome|cytosol|plasma membrane|multicellular organism development|inclusion body|PML body|extrinsic component of membrane|axon|nuclear membrane|aggrephagy|perikaryon|metal ion binding|extrinsic component of autophagosome membrane WDFY4 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00303828 0 GeneID:57705,Genbank:XM_017016465.2,HGNC:HGNC:29323,MIM:613316 WDFY family member 4 GO:0016021 integral component of membrane WDHD1 188.83828481424 195.918631575048 181.757938053432 0.927721557629439 -0.108236228871287 0.758691002737252 1 1.21352 0.936366 1.2224 0.797197 GeneID:11169,Genbank:NM_001008396.2,HGNC:HGNC:23170,MIM:608126 WD repeat and HMG-box DNA binding protein 1 GO:0000775,GO:0003677,GO:0003682,GO:0003723,GO:0005654,GO:0005737,GO:0006396,GO:0033044,GO:0070063,GO:0070829 chromosome, centromeric region|DNA binding|chromatin binding|RNA binding|nucleoplasm|cytoplasm|RNA processing|regulation of chromosome organization|RNA polymerase binding|heterochromatin maintenance WDPCP 49.4638626851605 48.525860448032 50.401864922289 1.03865989097228 0.0547233212927636 0.931809394213989 1 0.0632148 0.109543 0.0956852 0.0890941 GeneID:51057,Genbank:NM_015910.6,HGNC:HGNC:28027,MIM:613580 WD repeat containing planar cell polarity effector GO:0001822,GO:0002093,GO:0005886,GO:0005930,GO:0007224,GO:0010762,GO:0016476,GO:0032185,GO:0032880,GO:0042733,GO:0043010,GO:0045184,GO:0051893,GO:0055123,GO:0060021,GO:0060271,GO:0060541,GO:0072358,GO:0090521,GO:0097541,GO:1900027,GO:2000114 kidney development|auditory receptor cell morphogenesis|plasma membrane|axoneme|smoothened signaling pathway|regulation of fibroblast migration|regulation of embryonic cell shape|septin cytoskeleton organization|regulation of protein localization|embryonic digit morphogenesis|camera-type eye development|establishment of protein localization|regulation of focal adhesion assembly|digestive system development|palate development|cilium assembly|respiratory system development|cardiovascular system development|glomerular visceral epithelial cell migration|axonemal basal plate|regulation of ruffle assembly|regulation of establishment of cell polarity WDR1 14848.2047353886 13288.170513386 16408.2389573912 1.23480045209099 0.304277916272118 0.0192660668981117 0.567967248609484 115.713 117.38 146.619 146.823 GeneID:9948,Genbank:NM_017491.4,HGNC:HGNC:12754,MIM:604734 WD repeat domain 1 GO:0002102,GO:0002446,GO:0002576,GO:0005576,GO:0005829,GO:0005886,GO:0005911,GO:0007605,GO:0008360,GO:0030043,GO:0030054,GO:0030220,GO:0030834,GO:0030836,GO:0030864,GO:0030865,GO:0040011,GO:0042247,GO:0042643,GO:0042995,GO:0043209,GO:0043297,GO:0045199,GO:0045214,GO:0048713,GO:0051015,GO:0060307,GO:0070062,GO:1990266 podosome|neutrophil mediated immunity|platelet degranulation|extracellular region|cytosol|plasma membrane|cell-cell junction|sensory perception of sound|regulation of cell shape|actin filament fragmentation|cell junction|platelet formation|regulation of actin filament depolymerization|positive regulation of actin filament depolymerization|cortical actin cytoskeleton|cortical cytoskeleton organization|locomotion|establishment of planar polarity of follicular epithelium|actomyosin, actin portion|cell projection|myelin sheath|apical junction assembly|maintenance of epithelial cell apical/basal polarity|sarcomere organization|regulation of oligodendrocyte differentiation|actin filament binding|regulation of ventricular cardiac muscle cell membrane repolarization|extracellular exosome|neutrophil migration WDR11 1200.33932446343 1226.36557939598 1174.31306953088 0.957555470620159 -0.0625720309614022 0.690300469921264 1 9.142 8.57926 9.47342 7.94903 GeneID:55717,Genbank:NM_018117.11,HGNC:HGNC:13831,MIM:606417 WD repeat domain 11 GO:0005634,GO:0005737,GO:0005765,GO:0005829,GO:0015630,GO:0016020,GO:0016021 nucleus|cytoplasm|lysosomal membrane|cytosol|microtubule cytoskeleton|membrane|integral component of membrane WDR12 820.980313924589 920.383813135225 721.576814713952 0.783995551003825 -0.351082627489393 0.0282682337799649 0.668561867500627 9.01135 8.14408 6.77696 7.13855 GeneID:55759,Genbank:XM_011511469.3,HGNC:HGNC:14098,MIM:616620 WD repeat domain 12 GO:0000463,GO:0000466,GO:0005654,GO:0005730,GO:0006364,GO:0007219,GO:0008283,GO:0030687,GO:0042273,GO:0070545 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|nucleoplasm|nucleolus|rRNA processing|Notch signaling pathway|cell proliferation|preribosome, large subunit precursor|ribosomal large subunit biogenesis|PeBoW complex WDR13 782.454538141663 728.502439636277 836.406636647049 1.14811782519856 0.199270705695648 0.233334351145596 1 13.123 13.9485 15.0507 17.0477 GeneID:64743,Genbank:XM_024452424.1,HGNC:HGNC:14352,MIM:300512 WD repeat domain 13 GO:0005634 nucleus WDR17 44.9096020419058 49.1021757442513 40.7170283395602 0.829230634333493 -0.270154679857506 0.557491228457869 1 0.25809 0.20629 0.26191 0.137291 GeneID:116966,Genbank:NM_170710.4,HGNC:HGNC:16661,MIM:609005 WD repeat domain 17 GO:0005737 cytoplasm WDR18 836.871490557199 852.277764921679 821.46521619272 0.96384682318705 -0.053124206717824 0.713907202903046 1 26.1519 30.9838 29.5656 26.2558 GeneID:57418,Genbank:NM_024100.3,HGNC:HGNC:17956 WD repeat domain 18 GO:0005654,GO:0005730,GO:0005737,GO:0006364,GO:0007275 nucleoplasm|nucleolus|cytoplasm|rRNA processing|multicellular organism development WDR19 310.682959257576 316.531997384642 304.83392113051 0.963042989805807 -0.0543278941235845 0.801025021574242 1 2.28475 2.26827 2.31257 2.11598 GeneID:57728,Genbank:NM_025132.3,HGNC:HGNC:18340,MIM:608151 WD repeat domain 19 GO:0000902,GO:0001701,GO:0001750,GO:0005654,GO:0005737,GO:0005856,GO:0005929,GO:0008406,GO:0016604,GO:0030326,GO:0030991,GO:0031076,GO:0031514,GO:0032391,GO:0035721,GO:0035735,GO:0042471,GO:0048701,GO:0050877,GO:0055123,GO:0060271,GO:0060830,GO:0060831,GO:0061055,GO:0097542,GO:0097730 cell morphogenesis|in utero embryonic development|photoreceptor outer segment|nucleoplasm|cytoplasm|cytoskeleton|cilium|gonad development|nuclear body|embryonic limb morphogenesis|intraciliary transport particle A|embryonic camera-type eye development|motile cilium|photoreceptor connecting cilium|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ear morphogenesis|embryonic cranial skeleton morphogenesis|nervous system process|digestive system development|cilium assembly|ciliary receptor clustering involved in smoothened signaling pathway|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|myotome development|ciliary tip|non-motile cilium WDR20 394.605840913086 378.241759410838 410.969922415333 1.08652710122614 0.119724160084708 0.525851367195689 1 1.5103 1.59658 1.7372 1.62673 GeneID:91833,Genbank:NM_001353662.1,HGNC:HGNC:19667,MIM:617741 WD repeat domain 20 GO:0005654,GO:0016579,GO:0036459 nucleoplasm|protein deubiquitination|thiol-dependent ubiquitinyl hydrolase activity WDR24 373.421505509657 347.502548257326 399.340462761989 1.14917276078873 0.200595701724142 0.29537871721186 1 3.74783 4.02562 4.60563 4.13126 GeneID:84219,Genbank:XM_011522699.2,HGNC:HGNC:20852 WD repeat domain 24 GO:0005765,GO:0006914,GO:0010506,GO:0032008,GO:0034198,GO:0061700 lysosomal membrane|autophagy|regulation of autophagy|positive regulation of TOR signaling|cellular response to amino acid starvation|GATOR2 complex hsa04150 mTOR signaling pathway WDR25 180.174264591748 168.927503848671 191.421025334826 1.13315487989632 0.180345062559518 0.458881858454208 1 1.89871 2.07609 2.18154 2.2773 GeneID:79446,Genbank:NM_001350948.1,HGNC:HGNC:21064 WD repeat domain 25 WDR26 2312.96675354679 2281.60425496288 2344.32925213069 1.02749161999999 0.0391266276453981 0.771046973510164 1 12.3319 12.1998 13.8685 11.0482 GeneID:80232,Genbank:NM_001115113.2,HGNC:HGNC:21208,MIM:617424 WD repeat domain 26 GO:0005654,GO:0005737,GO:0005739,GO:0005829 nucleoplasm|cytoplasm|mitochondrion|cytosol WDR27 197.395698116865 216.934883930276 177.856512303453 0.81986128317019 -0.286548262000195 0.242036668923241 1 0.193247 0.3079 0.165063 0.199735 GeneID:253769,Genbank:XM_011535688.3,HGNC:HGNC:21248 WD repeat domain 27 GO:0005654 nucleoplasm WDR3 1525.98550349556 1699.86145322847 1352.10955376265 0.795423386532267 -0.330205114919087 0.0235445879498764 0.618180525582328 15.1493 14.1936 12.0153 11.6285 GeneID:10885,Genbank:NM_006784.2,HGNC:HGNC:12755,MIM:604737 WD repeat domain 3 GO:0003723,GO:0005634,GO:0005654,GO:0005730,GO:0006364,GO:0030490,GO:0030515,GO:0031965,GO:0032040,GO:0034388 RNA binding|nucleus|nucleoplasm|nucleolus|rRNA processing|maturation of SSU-rRNA|snoRNA binding|nuclear membrane|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome hsa03008 Ribosome biogenesis in eukaryotes WDR31 72.1577715693278 57.0972056547319 87.2183374839237 1.52754126027349 0.611211349070528 0.122035190857057 1 0.312805 0.463589 0.497445 0.712799 GeneID:114987,Genbank:NM_001006615.2,HGNC:HGNC:21421 WD repeat domain 31 WDR33 2041.27778631794 2107.69960185549 1974.8559707804 0.936972217977296 -0.0939218235029984 0.510555750637795 1 5.19416 5.19394 5.09179 4.78641 GeneID:55339,Genbank:NM_018383.4,HGNC:HGNC:25651 WD repeat domain 33 GO:0001650,GO:0005581,GO:0005634,GO:0005654,GO:0005847,GO:0006378,GO:0006379 fibrillar center|collagen trimer|nucleus|nucleoplasm|mRNA cleavage and polyadenylation specificity factor complex|mRNA polyadenylation|mRNA cleavage hsa03015 mRNA surveillance pathway WDR34 2195.19923493791 2087.02461842733 2303.3738514485 1.10366395830261 0.142300969680155 0.32590109087807 1 53.2941 56.6824 61.8915 61.109 GeneID:89891,Genbank:XM_011519179.2,HGNC:HGNC:28296,MIM:613363 WD repeat domain 34 GO:0005814,GO:0005829,GO:0005868,GO:0005929,GO:0005930,GO:0035735,GO:0036064,GO:0042073,GO:0045503,GO:0045504,GO:0060271,GO:0097014,GO:0097542 centriole|cytosol|cytoplasmic dynein complex|cilium|axoneme|intraciliary transport involved in cilium assembly|ciliary basal body|intraciliary transport|dynein light chain binding|dynein heavy chain binding|cilium assembly|ciliary plasm|ciliary tip WDR35 198.701548862991 232.134872044353 165.268225681628 0.711949153637076 -0.490153885177511 0.203482766857888 1 1.35592 0.928187 0.90147 0.77588 GeneID:57539,Genbank:XM_011533007.2,HGNC:HGNC:29250,MIM:613602 WD repeat domain 35 GO:0005813,GO:0005929,GO:0005930,GO:0009636,GO:0010629,GO:0030991,GO:0032496,GO:0035091,GO:0035721,GO:0035735,GO:0036064,GO:0043280,GO:0045019,GO:0060271,GO:0061512,GO:0071333,GO:0071356,GO:0090200,GO:0097421,GO:0097542,GO:0097756,GO:1905705,GO:1990830 centrosome|cilium|axoneme|response to toxic substance|negative regulation of gene expression|intraciliary transport particle A|response to lipopolysaccharide|phosphatidylinositol binding|intraciliary retrograde transport|intraciliary transport involved in cilium assembly|ciliary basal body|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of nitric oxide biosynthetic process|cilium assembly|protein localization to cilium|cellular response to glucose stimulus|cellular response to tumor necrosis factor|positive regulation of release of cytochrome c from mitochondria|liver regeneration|ciliary tip|negative regulation of blood vessel diameter|cellular response to paclitaxel|cellular response to leukemia inhibitory factor WDR36 490.803925749649 545.380448439349 436.227403059949 0.799858895397239 -0.322182580969558 0.258759077420982 1 4.05543 3.32855 3.64197 2.45203 GeneID:134430,Genbank:NM_139281.2,HGNC:HGNC:30696,MIM:609669 WD repeat domain 36 GO:0001895,GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0007601,GO:0030516,GO:0032040,GO:0034388,GO:0050896 retina homeostasis|RNA binding|nucleoplasm|nucleolus|rRNA processing|visual perception|regulation of axon extension|small-subunit processome|Pwp2p-containing subcomplex of 90S preribosome|response to stimulus hsa03008 Ribosome biogenesis in eukaryotes WDR37 441.974148773497 424.029105200974 459.919192346021 1.08464062184608 0.117217108139965 0.526556721553269 1 3.47131 3.7662 4.22623 3.91589 GeneID:22884,Genbank:NM_014023.3,HGNC:HGNC:31406 WD repeat domain 37 GO:0000460,GO:0000470,GO:0030687,GO:0070545 maturation of 5.8S rRNA|maturation of LSU-rRNA|preribosome, large subunit precursor|PeBoW complex WDR38 21.6466697143635 21.0054266992657 22.2879127294613 1.06105498586422 0.0854994213593067 0.930932535304636 1 0 0 0.0295017 0 GeneID:401551,Genbank:NM_001276374.1,HGNC:HGNC:23745 WD repeat domain 38 WDR4 481.177743352881 505.331914650356 457.023572055406 0.904402747591401 -0.144962719858438 0.393462122793263 1 5.68256 6.41787 6.17807 4.62081 GeneID:10785,Genbank:XM_017028264.1,HGNC:HGNC:12756,MIM:605924 WD repeat domain 4 GO:0005634,GO:0005654,GO:0005829,GO:0006400,GO:0043527,GO:0106004 nucleus|nucleoplasm|cytosol|tRNA modification|tRNA methyltransferase complex|tRNA (guanine-N7)-methylation WDR41 1381.98607331308 1318.69989971695 1445.2722469092 1.09598267749881 0.132224996031962 0.365019667883999 1 8.52444 8.52275 10.6084 8.24698 GeneID:55255,Genbank:XM_011543505.2,HGNC:HGNC:25601,MIM:617502 WD repeat domain 41 GO:0005737,GO:0005765,GO:0006914,GO:0010506,GO:0032045,GO:0065009 cytoplasm|lysosomal membrane|autophagy|regulation of autophagy|guanyl-nucleotide exchange factor complex|regulation of molecular function WDR43 747.259392767764 860.577518787921 633.941266747606 0.736646325179956 -0.44095596861646 0.0063382053318933 0.317227176861259 9.1543 8.54285 7.3078 5.86535 GeneID:23160,Genbank:NM_015131.2,HGNC:HGNC:28945,MIM:616195 WD repeat domain 43 GO:0001650,GO:0003723,GO:0005654,GO:0005730,GO:0006351,GO:0006364,GO:0045943,GO:2000234 fibrillar center|RNA binding|nucleoplasm|nucleolus|transcription, DNA-templated|rRNA processing|positive regulation of transcription from RNA polymerase I promoter|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes WDR44 581.584497355464 611.106834230573 552.062160480355 0.903380766761413 -0.146593896180902 0.516438465341353 1 5.44124 4.83267 5.53606 3.91258 GeneID:54521,Genbank:NM_019045.4,HGNC:HGNC:30512 WD repeat domain 44 GO:0005794,GO:0005829,GO:0010008,GO:0048471 Golgi apparatus|cytosol|endosome membrane|perinuclear region of cytoplasm WDR45 557.537650598093 531.612456911567 583.462844284618 1.09753418434602 0.134265875358292 0.445031595571913 1 7.5021 7.93497 8.42047 9.00503 GeneID:11152,Genbank:NM_007075.3,HGNC:HGNC:28912,MIM:300526 WD repeat domain 45 GO:0000422,GO:0005829,GO:0006497,GO:0006914,GO:0019898,GO:0032266,GO:0034045,GO:0034497,GO:0044804,GO:0080025 autophagy of mitochondrion|cytosol|protein lipidation|autophagy|extrinsic component of membrane|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|protein localization to phagophore assembly site|autophagy of nucleus|phosphatidylinositol-3,5-bisphosphate binding WDR45B 4791.24732400799 4696.98143635248 4885.51321166349 1.04013892280942 0.0567762301578799 0.683749140458637 1 45.1265 48.1786 50.6358 48.6477 GeneID:56270,Genbank:NM_019613.3,HGNC:HGNC:25072,MIM:609226 WD repeat domain 45B GO:0000422,GO:0005829,GO:0006497,GO:0019898,GO:0032266,GO:0034045,GO:0034497,GO:0044804,GO:0080025 autophagy of mitochondrion|cytosol|protein lipidation|extrinsic component of membrane|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|protein localization to phagophore assembly site|autophagy of nucleus|phosphatidylinositol-3,5-bisphosphate binding WDR46 2047.2178163721 2174.90702750855 1919.52860523565 0.882579614189096 -0.180201670537381 0.1957309463105 1 19.2512 19.0014 16.3194 17.1446 GeneID:9277,Genbank:XM_017011484.2,HGNC:HGNC:13923,MIM:611440 WD repeat domain 46 GO:0000462,GO:0003723,GO:0005654,GO:0005730,GO:0006364,GO:0030686,GO:0032040,GO:1903955 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA binding|nucleoplasm|nucleolus|rRNA processing|90S preribosome|small-subunit processome|positive regulation of protein targeting to mitochondrion WDR47 296.173684172893 344.215110266825 248.132258078961 0.720863932692022 -0.472201126899785 0.0335613692082061 0.723443996283484 2.83587 2.28711 1.78811 1.71657 GeneID:22911,Genbank:XM_011541028.3,HGNC:HGNC:29141,MIM:615734 WD repeat domain 47 GO:0005737,GO:0005874,GO:0007275 cytoplasm|microtubule|multicellular organism development WDR48 749.648696848631 749.582267572987 749.715126124275 1.0001772434555 0.000255685595653568 0.96530576307272 1 5.2974 4.30717 4.79028 4.83616 GeneID:57599,Genbank:NM_001346225.1,HGNC:HGNC:30914,MIM:612167 WD repeat domain 48 GO:0000724,GO:0005634,GO:0005654,GO:0005764,GO:0005770,GO:0007283,GO:0007338,GO:0016032,GO:0016579,GO:0035264,GO:0036297,GO:0036459,GO:0042769,GO:0043231,GO:0043588,GO:0048568,GO:0048705,GO:0048872,GO:0050679,GO:0072520,GO:1902525 double-strand break repair via homologous recombination|nucleus|nucleoplasm|lysosome|late endosome|spermatogenesis|single fertilization|viral process|protein deubiquitination|multicellular organism growth|interstrand cross-link repair|thiol-dependent ubiquitinyl hydrolase activity|DNA damage response, detection of DNA damage|intracellular membrane-bounded organelle|skin development|embryonic organ development|skeletal system morphogenesis|homeostasis of number of cells|positive regulation of epithelial cell proliferation|seminiferous tubule development|regulation of protein monoubiquitination hsa03460 Fanconi anemia pathway WDR49 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00904998 0 0 0 GeneID:151790,Genbank:NM_001348951.1,HGNC:HGNC:26587 WD repeat domain 49 WDR5 1676.45549420233 1729.41286717253 1623.49812123214 0.938756818599625 -0.091176613299985 0.503816678080467 1 19.702 21.8168 20.1923 19.7585 GeneID:11091,Genbank:XM_024447393.1,HGNC:HGNC:12757,MIM:609012 WD repeat domain 5 GO:0000123,GO:0001501,GO:0005634,GO:0005654,GO:0005671,GO:0006351,GO:0018024,GO:0031175,GO:0035064,GO:0035097,GO:0035948,GO:0036064,GO:0043687,GO:0043966,GO:0043981,GO:0043982,GO:0043984,GO:0044666,GO:0045652,GO:0048188,GO:0051568,GO:0060271,GO:0071339 histone acetyltransferase complex|skeletal system development|nucleus|nucleoplasm|Ada2/Gcn5/Ada3 transcription activator complex|transcription, DNA-templated|histone-lysine N-methyltransferase activity|neuron projection development|methylated histone binding|histone methyltransferase complex|positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter|ciliary basal body|post-translational protein modification|histone H3 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|histone H4-K16 acetylation|MLL3/4 complex|regulation of megakaryocyte differentiation|Set1C/COMPASS complex|histone H3-K4 methylation|cilium assembly|MLL1 complex hsa04934 Cushing syndrome WDR53 382.634488193517 374.647563462866 390.621412924167 1.04263700346442 0.060236967585675 0.741757759569511 1 3.47503 3.55014 4.10516 3.8223 GeneID:348793,Genbank:NM_001345915.1,HGNC:HGNC:28786,MIM:615110 WD repeat domain 53 GO:0005737 cytoplasm WDR54 638.583946090605 615.720407602892 661.447484578318 1.07426597593776 0.103351232299006 0.611192351977901 1 20.8608 21.4733 20.3697 23.2858 GeneID:84058,Genbank:XM_017005064.1,HGNC:HGNC:25770 WD repeat domain 54 WDR55 2115.08078808397 2139.47780774356 2090.68376842438 0.977193481912933 -0.0332838543309541 0.81122478044059 1 14.1252 14.4175 14.7446 14.2046 GeneID:54853,Genbank:NM_017706.4,HGNC:HGNC:25971 WD repeat domain 55 GO:0005730,GO:0005737,GO:0006364,GO:0042273 nucleolus|cytoplasm|rRNA processing|ribosomal large subunit biogenesis WDR59 537.419712382423 530.632314107653 544.207110657193 1.02558230282747 0.0364432725262582 0.853301010604642 1 2.20845 2.3081 2.20012 2.37127 GeneID:79726,Genbank:XM_005256146.3,HGNC:HGNC:25706,MIM:617418 WD repeat domain 59 GO:0005765,GO:0032008,GO:0034198,GO:0061700 lysosomal membrane|positive regulation of TOR signaling|cellular response to amino acid starvation|GATOR2 complex hsa04150 mTOR signaling pathway WDR5B 91.0821601193097 90.0848600641832 92.0794601744362 1.02214134660177 0.0315947128520995 0.924499021345574 1 1.00877 0.937377 1.03288 0.990349 GeneID:54554,Genbank:NM_019069.3,HGNC:HGNC:17826 WD repeat domain 5B GO:0036064,GO:0060271 ciliary basal body|cilium assembly hsa04934 Cushing syndrome WDR6 6572.45861544043 6580.9047719605 6564.01245892036 0.997433132126131 -0.00370796852343108 0.971713200939649 1 64.5173 64.089 63.7598 66.8323 GeneID:11180,Genbank:NM_001320546.1,HGNC:HGNC:12758,MIM:606031 WD repeat domain 6 GO:0003723,GO:0005737,GO:0005829,GO:0005886,GO:0007050,GO:0008285,GO:0010507 RNA binding|cytoplasm|cytosol|plasma membrane|cell cycle arrest|negative regulation of cell proliferation|negative regulation of autophagy WDR60 338.86594074209 352.027843733673 325.704037750506 0.925222375298577 -0.112127938790087 0.574863822204049 1 1.79955 1.75109 1.93513 1.5562 GeneID:55112,Genbank:NM_001350914.1,HGNC:HGNC:21862,MIM:615462 WD repeat domain 60 GO:0000242,GO:0005615,GO:0005868,GO:0005929,GO:0007018,GO:0035735,GO:0045503,GO:0045504,GO:0048704,GO:0060271,GO:0070062,GO:0097542,GO:0097546 pericentriolar material|extracellular space|cytoplasmic dynein complex|cilium|microtubule-based movement|intraciliary transport involved in cilium assembly|dynein light chain binding|dynein heavy chain binding|embryonic skeletal system morphogenesis|cilium assembly|extracellular exosome|ciliary tip|ciliary base WDR61 2106.6416223416 2100.48381799593 2112.79942668727 1.00586322474176 0.00843414370994257 0.955656917093055 1 20.9031 20.7145 20.3132 23.0265 GeneID:80349,Genbank:XM_011522094.2,HGNC:HGNC:30300,MIM:609540 WD repeat domain 61 GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006366,GO:0006368,GO:0016055,GO:0016567,GO:0016593,GO:0032968,GO:0035327,GO:0043928,GO:0045638,GO:0045944,GO:0051571,GO:0055087,GO:0080182,GO:2001162 nucleus|nucleoplasm|cytoplasm|cytosol|transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|Wnt signaling pathway|protein ubiquitination|Cdc73/Paf1 complex|positive regulation of transcription elongation from RNA polymerase II promoter|transcriptionally active chromatin|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|negative regulation of myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|Ski complex|histone H3-K4 trimethylation|positive regulation of histone H3-K79 methylation hsa03018 RNA degradation WDR62 1695.74921432109 1617.23454239898 1774.26388624319 1.09709744612014 0.133691674137272 0.350358064234786 1 10.4418 10.1572 12.0038 10.8905 GeneID:284403,Genbank:XM_017026665.1,HGNC:HGNC:24502,MIM:613583 WD repeat domain 62 GO:0000922,GO:0003723,GO:0005634,GO:0005682,GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0007052,GO:0007099,GO:0008380,GO:0021987,GO:0022008,GO:0071011,GO:0071013 spindle pole|RNA binding|nucleus|U5 snRNP|centrosome|centriole|microtubule organizing center|cytosol|mitotic spindle organization|centriole replication|RNA splicing|cerebral cortex development|neurogenesis|precatalytic spliceosome|catalytic step 2 spliceosome WDR63 7.29202660176774 9.253521707397 5.33053149613849 0.576054356891757 -0.795723143084087 0.496144260674124 1 0.0803381 0.0868048 0.0290184 0.0358718 GeneID:126820,Genbank:NM_145172.4,HGNC:HGNC:30711 WD repeat domain 63 GO:0007018,GO:0030286,GO:0045503,GO:0045504 microtubule-based movement|dynein complex|dynein light chain binding|dynein heavy chain binding WDR66 24.4416807283339 22.7157722785625 26.1675891781053 1.15195683673939 0.204086660713685 0.738754473557701 1 0.114841 0.11433 0.103005 0.102221 GeneID:144406,Genbank:NM_144668.5,HGNC:HGNC:28506 WD repeat domain 66 GO:0003341,GO:0005930,GO:0031514 cilium movement|axoneme|motile cilium WDR7 191.637785879182 196.678260315754 186.597311442609 0.948743959515605 -0.0759092997132755 0.757539330442707 1 0.8163 0.843674 0.935747 0.735892 GeneID:23335,Genbank:XM_011525888.2,HGNC:HGNC:13490,MIM:613473 WD repeat domain 7 GO:0002244,GO:0005737,GO:0008021 hematopoietic progenitor cell differentiation|cytoplasm|synaptic vesicle WDR70 513.415421622219 530.103008085263 496.727835159175 0.937040212153031 -0.0938171338450142 0.600252400143279 1 7.20744 6.99735 6.3116 6.58398 GeneID:55100,Genbank:NM_018034.3,HGNC:HGNC:25495,MIM:617233 WD repeat domain 70 GO:0019899 enzyme binding WDR72 1.24125200715389 1.02816907859967 1.45433493570811 1.4144900541931 0.500282032643154 1 1 0.00593732 0.00578691 0.0115065 0.00534719 GeneID:256764,Genbank:NM_182758.3,HGNC:HGNC:26790,MIM:613214 WD repeat domain 72 GO:0005737,GO:0005768,GO:0070166 cytoplasm|endosome|enamel mineralization WDR73 643.457859313594 643.365302865497 643.55041576169 1.00028772595502 0.000415041102253363 1 1 7.23259 7.04578 6.99622 7.55039 GeneID:84942,Genbank:NM_032856.3,HGNC:HGNC:25928,MIM:616144 WD repeat domain 73 GO:0000922,GO:0005829,GO:0006997,GO:0031122,GO:0032154,GO:0043066 spindle pole|cytosol|nucleus organization|cytoplasmic microtubule organization|cleavage furrow|negative regulation of apoptotic process WDR74 826.956712950916 860.126682006395 793.786743895436 0.922871898408953 -0.115797690089074 0.463246580547906 1 6.83542 7.21642 6.75554 6.57128 GeneID:54663,Genbank:XM_024448586.1,HGNC:HGNC:25529 WD repeat domain 74 GO:0005634,GO:0005730,GO:0030687,GO:0042273 nucleus|nucleolus|preribosome, large subunit precursor|ribosomal large subunit biogenesis WDR75 493.950336511583 528.430880125544 459.469792897623 0.869498377514318 -0.201744759424772 0.256793897114594 1 4.12649 4.19448 4.24538 3.32627 GeneID:84128,Genbank:NM_001303096.1,HGNC:HGNC:25725 WD repeat domain 75 GO:0003723,GO:0005654,GO:0005730,GO:0006351,GO:0006364,GO:0045943,GO:1903146,GO:1903955,GO:2000234 RNA binding|nucleoplasm|nucleolus|transcription, DNA-templated|rRNA processing|positive regulation of transcription from RNA polymerase I promoter|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion|positive regulation of rRNA processing hsa03008 Ribosome biogenesis in eukaryotes WDR76 1439.47038884249 1441.95471063422 1436.98606705076 0.996554230485315 -0.00497977911212897 0.986742655190067 1 13.6623 13.5591 14.1455 12.6162 GeneID:79968,Genbank:NM_024908.3,HGNC:HGNC:25773 WD repeat domain 76 GO:0003677,GO:0005634,GO:0006974,GO:2000001 DNA binding|nucleus|cellular response to DNA damage stimulus|regulation of DNA damage checkpoint WDR77 1762.98152555328 1850.61133993259 1675.35171117397 0.90529636073396 -0.143537940072567 0.303419938738145 1 28.1742 29.9651 26.4483 25.6273 GeneID:79084,Genbank:NM_001317064.1,HGNC:HGNC:29652,MIM:611734 WD repeat domain 77 WDR78 16.8505248473824 16.2586001588549 17.44244953591 1.07281373337731 0.101399610800697 0.945634304614417 1 0.0335643 0.0988322 0.0895081 0.143547 GeneID:79819,Genbank:NM_024763.4,HGNC:HGNC:26252 WD repeat domain 78 GO:0002244,GO:0003341,GO:0005858,GO:0045503,GO:0045504 hematopoietic progenitor cell differentiation|cilium movement|axonemal dynein complex|dynein light chain binding|dynein heavy chain binding WDR81 932.981873528722 929.629560189224 936.334186868219 1.00721214875916 0.0103675897272385 0.961963151523843 1 5.56752 5.63993 6.05176 5.40363 GeneID:124997,Genbank:NM_152348.3,HGNC:HGNC:26600,MIM:614218 WD repeat domain 81 GO:0000421,GO:0005739,GO:0005765,GO:0005829,GO:0006511,GO:0007005,GO:0010923,GO:0031313,GO:0031901,GO:0031902,GO:0035014,GO:0035973,GO:0043551,GO:0045022,GO:0050821,GO:0070530 autophagosome membrane|mitochondrion|lysosomal membrane|cytosol|ubiquitin-dependent protein catabolic process|mitochondrion organization|negative regulation of phosphatase activity|extrinsic component of endosome membrane|early endosome membrane|late endosome membrane|phosphatidylinositol 3-kinase regulator activity|aggrephagy|regulation of phosphatidylinositol 3-kinase activity|early endosome to late endosome transport|protein stabilization|K63-linked polyubiquitin modification-dependent protein binding WDR82 5013.60129642753 5241.0935843398 4786.10900851526 0.913188999871321 -0.131014613693864 0.318984852679596 1 54.4672 57.2095 51.8913 51.0818 GeneID:80335,Genbank:NM_025222.3,HGNC:HGNC:28826,MIM:611059 WD repeat domain 82 GO:0000785,GO:0003682,GO:0005730,GO:0035097,GO:0048188,GO:0051568,GO:0072357,GO:0080182 chromatin|chromatin binding|nucleolus|histone methyltransferase complex|Set1C/COMPASS complex|histone H3-K4 methylation|PTW/PP1 phosphatase complex|histone H3-K4 trimethylation hsa03015 mRNA surveillance pathway WDR83 392.471823846756 409.874869474003 375.068778219509 0.915081177581925 -0.128028363184604 0.487303918406269 1 8.54281 9.04605 8.43494 8.81564 GeneID:84292,Genbank:NM_001099737.2,HGNC:HGNC:32672,MIM:616850 WD repeat domain 83 GO:0000165,GO:0000375,GO:0000398,GO:0005681,GO:0010008,GO:0071013 MAPK cascade|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|spliceosomal complex|endosome membrane|catalytic step 2 spliceosome WDR83OS 2184.6678202998 2110.09517493804 2259.24046566155 1.07068178369153 0.0985297617817996 0.497380096372522 1 51.242 54.2878 55.8622 58.8162 GeneID:51398,Genbank:NM_016145.3,HGNC:HGNC:30203 WD repeat domain 83 opposite strand GO:0016021 integral component of membrane WDR86 9.84232853431105 10.9638672866938 8.72078978192829 0.795411833606579 -0.330226069130294 0.789981747442338 1 0.105808 0.0498547 0.0453937 0.0847927 GeneID:349136,Genbank:XM_011516151.3,HGNC:HGNC:28020 WD repeat domain 86 WDR88 2.21171523187983 1.51824048055703 2.90518998320264 1.91352425416608 0.936232187467533 0.787092304331098 1 0 0.0115719 0 0 GeneID:126248,Genbank:NM_173479.3,HGNC:HGNC:26999 WD repeat domain 88 WDR89 87.1137433296642 100.068584546962 74.1589021123662 0.741080754245738 -0.432297335889284 0.180626494807726 1 1.00353 0.949505 0.929364 0.580622 GeneID:112840,Genbank:NM_080666.3,HGNC:HGNC:20489 WD repeat domain 89 WDR90 259.572442776605 254.535094711192 264.609790842017 1.03958077428284 0.0560018583693872 0.82823833002773 1 1.73054 2.01871 2.04626 1.99734 GeneID:197335,Genbank:XM_017023023.1,HGNC:HGNC:26960 WD repeat domain 90 WDR91 574.831787334151 572.527497646598 577.136077021704 1.00804953368013 0.0115665319319695 0.957569153684323 1 3.61859 3.69883 3.52378 4.07354 GeneID:29062,Genbank:NM_014149.3,HGNC:HGNC:24997,MIM:616303 WD repeat domain 91 GO:0005829,GO:0031313,GO:0031901,GO:0031902,GO:0035014,GO:0043551,GO:0045022,GO:1903362 cytosol|extrinsic component of endosome membrane|early endosome membrane|late endosome membrane|phosphatidylinositol 3-kinase regulator activity|regulation of phosphatidylinositol 3-kinase activity|early endosome to late endosome transport|regulation of cellular protein catabolic process WDR92 317.711206686713 340.275938741805 295.146474631621 0.867373919304864 -0.205274030813875 0.305302708759367 1 4.15646 3.94419 3.78645 3.49132 GeneID:116143,Genbank:NM_138458.3,HGNC:HGNC:25176,MIM:610729 WD repeat domain 92 GO:0006915,GO:0043130 apoptotic process|ubiquitin binding WDR93 1.34524419160576 2.69048838321152 0 0 -Inf 0.430770198131168 1 0.00609794 0 0 0 GeneID:56964,Genbank:XM_011521794.2,HGNC:HGNC:26924 WD repeat domain 93 GO:0016651,GO:0022900 oxidoreductase activity, acting on NAD(P)H|electron transport chain WDR97 2.6972185204937 1.51824048055703 3.87619656043037 2.55308471225075 1.35224140766923 0.558041000233531 1 0 0.00957285 0.0207586 0.00970125 GeneID:340390,Genbank:NM_001316309.1,HGNC:HGNC:26959 WD repeat domain 97 GO:0005737 cytoplasm WDSUB1 148.174714836893 157.261842751064 139.087586922722 0.884433149768498 -0.177174994529318 0.499669417118346 1 1.46472 1.2568 1.37432 1.26462 GeneID:151525,Genbank:NM_001330279.1,HGNC:HGNC:26697 WD repeat, sterile alpha motif and U-box domain containing 1 GO:0004842 ubiquitin-protein transferase activity WDTC1 1402.95601229697 1263.40030053664 1542.51172405731 1.22092081456852 0.287969634286108 0.0493046689421876 0.813062736622003 8.30958 8.34125 9.98463 10.3641 GeneID:23038,Genbank:NM_001276252.1,HGNC:HGNC:29175 WD and tetratricopeptide repeats 1 GO:0000122,GO:0001701,GO:0004857,GO:0005654,GO:0005829,GO:0006006,GO:0008361,GO:0016567,GO:0032869,GO:0035264,GO:0042393,GO:0042826,GO:0043687,GO:0045717,GO:0055082 negative regulation of transcription from RNA polymerase II promoter|in utero embryonic development|enzyme inhibitor activity|nucleoplasm|cytosol|glucose metabolic process|regulation of cell size|protein ubiquitination|cellular response to insulin stimulus|multicellular organism growth|histone binding|histone deacetylase binding|post-translational protein modification|negative regulation of fatty acid biosynthetic process|cellular chemical homeostasis WDYHV1 302.010912354204 310.353174257936 293.668650450471 0.946240202481065 -0.0797216376015772 0.714837902057621 1 1.32611 1.08291 1.15036 1.17105 GeneID:55093,Genbank:NM_018024.2,HGNC:HGNC:25490 WDYHV motif containing 1 GO:0005634,GO:0005829,GO:0006464,GO:0070773 nucleus|cytosol|cellular protein modification process|protein-N-terminal glutamine amidohydrolase activity WEE1 1065.40952079093 1188.70753368527 942.111507896595 0.792551137432293 -0.33542407024753 0.0281570456504678 0.668561867500627 14.8803 13.6174 11.4889 10.9443 GeneID:7465,Genbank:NM_003390.3,HGNC:HGNC:12761,MIM:193525 WEE1 G2 checkpoint kinase GO:0000082,GO:0000086,GO:0000226,GO:0000287,GO:0004713,GO:0004715,GO:0005524,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0016301,GO:0030010,GO:0048812,GO:0051301,GO:0051726 G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|microtubule cytoskeleton organization|magnesium ion binding|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|ATP binding|nucleus|nucleoplasm|nucleolus|cytoplasm|kinase activity|establishment of cell polarity|neuron projection morphogenesis|cell division|regulation of cell cycle hsa04110,hsa05170 Cell cycle|Human immunodeficiency virus 1 infection WEE2 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0128757 0 GeneID:494551,Genbank:NM_001105558.1,HGNC:HGNC:19684,MIM:614084 WEE1 homolog 2 GO:0000278,GO:0000287,GO:0004715,GO:0005524,GO:0005654,GO:0005829,GO:0007143,GO:0035038,GO:0045736,GO:0060631,GO:1900194 mitotic cell cycle|magnesium ion binding|non-membrane spanning protein tyrosine kinase activity|ATP binding|nucleoplasm|cytosol|female meiotic nuclear division|female pronucleus assembly|negative regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of meiosis I|negative regulation of oocyte maturation hsa04110,hsa05170 Cell cycle|Human immunodeficiency virus 1 infection WFDC10B 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:280664,Genbank:NM_172131.2,HGNC:HGNC:20479 WAP four-disulfide core domain 10B GO:0005576,GO:0030414 extracellular region|peptidase inhibitor activity WFDC3 11.965930851903 13.7602168743831 10.1716448294228 0.739206723431734 -0.435950216085897 0.63380694972089 1 0.0445691 0.160409 0.0842472 0.155543 GeneID:140686,Genbank:XM_017027668.1,HGNC:HGNC:15957 WAP four-disulfide core domain 3 GO:0004867,GO:0005576 serine-type endopeptidase inhibitor activity|extracellular region WFIKKN1 1.0016543915721 1.51824048055703 0.48506830258717 0.319493722370782 -1.64614051048666 0.791481013618379 1 0 0.0658067 0.0365843 0 GeneID:117166,Genbank:NM_053284.2,HGNC:HGNC:30912,MIM:608021 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 GO:0001501,GO:0004867,GO:0005576,GO:0008191,GO:0030512,GO:0032091,GO:0043392,GO:0048019,GO:0048747,GO:0050431,GO:0060021 skeletal system development|serine-type endopeptidase inhibitor activity|extracellular region|metalloendopeptidase inhibitor activity|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of protein binding|negative regulation of DNA binding|receptor antagonist activity|muscle fiber development|transforming growth factor beta binding|palate development WFIKKN2 0.783133377620985 1.56626675524197 0 0 -Inf 0.554613367085733 1 0.0220178 0.00959735 0 0 GeneID:124857,Genbank:NM_001330341.1,HGNC:HGNC:30916,MIM:610895 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 GO:0001501,GO:0004867,GO:0005615,GO:0007179,GO:0008191,GO:0030512,GO:0032091,GO:0043392,GO:0048019,GO:0048747,GO:0050431,GO:0060021 skeletal system development|serine-type endopeptidase inhibitor activity|extracellular space|transforming growth factor beta receptor signaling pathway|metalloendopeptidase inhibitor activity|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of protein binding|negative regulation of DNA binding|receptor antagonist activity|muscle fiber development|transforming growth factor beta binding|palate development WFS1 1068.68297629109 1029.52463994681 1107.84131263537 1.07607071229748 0.105772885449289 0.48234134692864 1 13.6783 12.5473 14.6515 14.6345 GeneID:7466,Genbank:XM_017008586.1,HGNC:HGNC:12762,MIM:606201 wolframin ER transmembrane glycoprotein GO:0000122,GO:0000502,GO:0001822,GO:0003091,GO:0005516,GO:0005783,GO:0005788,GO:0005789,GO:0006983,GO:0007601,GO:0007605,GO:0022417,GO:0030176,GO:0030425,GO:0030433,GO:0031016,GO:0031398,GO:0031625,GO:0032469,GO:0033613,GO:0034976,GO:0036498,GO:0042048,GO:0042593,GO:0043069,GO:0043433,GO:0043524,GO:0043687,GO:0044267,GO:0045762,GO:0045927,GO:0048306,GO:0050821,GO:0050877,GO:0051117,GO:0051247,GO:0051928,GO:0055074,GO:1902236,GO:1903892,GO:2000675 negative regulation of transcription from RNA polymerase II promoter|proteasome complex|kidney development|renal water homeostasis|calmodulin binding|endoplasmic reticulum|endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER overload response|visual perception|sensory perception of sound|protein maturation by protein folding|integral component of endoplasmic reticulum membrane|dendrite|ubiquitin-dependent ERAD pathway|pancreas development|positive regulation of protein ubiquitination|ubiquitin protein ligase binding|endoplasmic reticulum calcium ion homeostasis|activating transcription factor binding|response to endoplasmic reticulum stress|IRE1-mediated unfolded protein response|olfactory behavior|glucose homeostasis|negative regulation of programmed cell death|negative regulation of DNA binding transcription factor activity|negative regulation of neuron apoptotic process|post-translational protein modification|cellular protein metabolic process|positive regulation of adenylate cyclase activity|positive regulation of growth|calcium-dependent protein binding|protein stabilization|nervous system process|ATPase binding|positive regulation of protein metabolic process|positive regulation of calcium ion transport|calcium ion homeostasis|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of ATF6-mediated unfolded protein response|negative regulation of type B pancreatic cell apoptotic process hsa04141 Protein processing in endoplasmic reticulum WHAMM 435.82980819634 454.412515121476 417.247101271204 0.918212169309782 -0.123100542289782 0.50334939341789 1 3.15753 3.15392 2.97793 2.75404 GeneID:123720,Genbank:NM_001080435.2,HGNC:HGNC:30493,MIM:612393 WAS protein homolog associated with actin, golgi membranes and microtubules GO:0000139,GO:0003779,GO:0005829,GO:0005874,GO:0006888,GO:0007015,GO:0007050,GO:0008017,GO:0017049,GO:0030032,GO:0030659,GO:0033116,GO:0034314,GO:0048041,GO:0051127,GO:0071933,GO:0090527,GO:0097320 Golgi membrane|actin binding|cytosol|microtubule|ER to Golgi vesicle-mediated transport|actin filament organization|cell cycle arrest|microtubule binding|GTP-Rho binding|lamellipodium assembly|cytoplasmic vesicle membrane|endoplasmic reticulum-Golgi intermediate compartment membrane|Arp2/3 complex-mediated actin nucleation|focal adhesion assembly|positive regulation of actin nucleation|Arp2/3 complex binding|actin filament reorganization|plasma membrane tubulation hsa04530 Tight junction WHRN 280.048344589172 271.754220363745 288.342468814599 1.06104136461487 0.0854809007027144 0.694288498449935 1 0.969651 1.05447 1.09339 1.13084 GeneID:25861,Genbank:XM_011518485.1,HGNC:HGNC:16361,MIM:607928 whirlin WIF1 1.02566752891457 1.56626675524197 0.48506830258717 0.309697119576692 -1.69107012999473 0.789536483244536 1 0.0482867 0.0223338 0.0229887 0 GeneID:11197,Genbank:NM_007191.4,HGNC:HGNC:18081,MIM:605186 WNT inhibitory factor 1 hsa04310 Wnt signaling pathway WIPF1 872.29523364469 885.821100316279 858.769366973102 0.969461403286151 -0.0447446327554971 0.781181656253309 1 6.90295 6.90988 6.97316 6.43382 GeneID:7456,Genbank:NM_001077269.1,HGNC:HGNC:12736,MIM:602357 WAS/WASL interacting protein family member 1 GO:0001726,GO:0003779,GO:0005522,GO:0005829,GO:0005884,GO:0006461,GO:0008154,GO:0015629,GO:0017124,GO:0030048,GO:0031410,GO:0038096,GO:0051707 ruffle|actin binding|profilin binding|cytosol|actin filament|protein complex assembly|actin polymerization or depolymerization|actin cytoskeleton|SH3 domain binding|actin filament-based movement|cytoplasmic vesicle|Fc-gamma receptor signaling pathway involved in phagocytosis|response to other organism hsa04144 Endocytosis WIPF2 2035.56516519022 1932.4326297484 2138.69770063203 1.10673855725075 0.146314457255131 0.307868662129889 1 9.2794 10.2182 11.3828 10.4783 GeneID:147179,Genbank:XM_011524412.1,HGNC:HGNC:30923,MIM:609692 WAS/WASL interacting protein family member 2 GO:0003779,GO:0005654,GO:0005829,GO:0005856,GO:0005886,GO:0038096 actin binding|nucleoplasm|cytosol|cytoskeleton|plasma membrane|Fc-gamma receptor signaling pathway involved in phagocytosis hsa04144 Endocytosis WIPF3 0.735107102936043 1.47021420587209 0 0 -Inf 0.565949120151783 1 0 0.0179519 0 0 GeneID:644150,Genbank:NM_001080529.2,HGNC:HGNC:22004,MIM:612432 WAS/WASL interacting protein family member 3 GO:0003779,GO:0005829,GO:0007275,GO:0007283,GO:0017124,GO:0030154,GO:0038096 actin binding|cytosol|multicellular organism development|spermatogenesis|SH3 domain binding|cell differentiation|Fc-gamma receptor signaling pathway involved in phagocytosis hsa04144 Endocytosis WIPI1 615.403775285396 538.76161418708 692.045936383713 1.28451233005514 0.361220738758794 0.031939731172566 0.70845034327151 3.39597 4.08603 5.23271 4.94979 GeneID:55062,Genbank:NM_001320772.1,HGNC:HGNC:25471,MIM:609224 WD repeat domain, phosphoinositide interacting 1 GO:0000139,GO:0000407,GO:0000421,GO:0000422,GO:0005102,GO:0005737,GO:0005802,GO:0005829,GO:0005856,GO:0006497,GO:0006914,GO:0010008,GO:0016236,GO:0019898,GO:0030136,GO:0030331,GO:0032266,GO:0034045,GO:0034497,GO:0036498,GO:0044804,GO:0048203,GO:0050681,GO:0080025 Golgi membrane|phagophore assembly site|autophagosome membrane|autophagy of mitochondrion|receptor binding|cytoplasm|trans-Golgi network|cytosol|cytoskeleton|protein lipidation|autophagy|endosome membrane|macroautophagy|extrinsic component of membrane|clathrin-coated vesicle|estrogen receptor binding|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|protein localization to phagophore assembly site|IRE1-mediated unfolded protein response|autophagy of nucleus|vesicle targeting, trans-Golgi to endosome|androgen receptor binding|phosphatidylinositol-3,5-bisphosphate binding hsa04136,hsa04140 Autophagy - other|Autophagy - animal WIPI2 2669.13151639927 2427.11724372464 2911.1457890739 1.19942528388388 0.262343290247017 0.0590840807613804 0.879410748501007 17.6628 18.7424 22.6051 21.8593 GeneID:26100,Genbank:NM_001278299.1,HGNC:HGNC:32225,MIM:609225 WD repeat domain, phosphoinositide interacting 2 GO:0000045,GO:0000407,GO:0000422,GO:0005654,GO:0005829,GO:0006497,GO:0010314,GO:0016236,GO:0019898,GO:0032266,GO:0034045,GO:0034497,GO:0043234,GO:0044804,GO:0061739,GO:0080025,GO:0098792 autophagosome assembly|phagophore assembly site|autophagy of mitochondrion|nucleoplasm|cytosol|protein lipidation|phosphatidylinositol-5-phosphate binding|macroautophagy|extrinsic component of membrane|phosphatidylinositol-3-phosphate binding|phagophore assembly site membrane|protein localization to phagophore assembly site|protein complex|autophagy of nucleus|protein lipidation involved in autophagosome assembly|phosphatidylinositol-3,5-bisphosphate binding|xenophagy hsa04136,hsa04140 Autophagy - other|Autophagy - animal WISP1 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0 0.00768769 0 GeneID:8840,Genbank:XM_024447319.1,HGNC:HGNC:12769,MIM:603398 WNT1 inducible signaling pathway protein 1 GO:0001558,GO:0005178,GO:0005520,GO:0005578,GO:0005615,GO:0005829,GO:0007155,GO:0007165,GO:0007267,GO:0008201,GO:0016055,GO:0060548 regulation of cell growth|integrin binding|insulin-like growth factor binding|proteinaceous extracellular matrix|extracellular space|cytosol|cell adhesion|signal transduction|cell-cell signaling|heparin binding|Wnt signaling pathway|negative regulation of cell death hsa04310 Wnt signaling pathway WISP2 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0 0.0213928 0 0 GeneID:8839,Genbank:XM_017028117.1,HGNC:HGNC:12770,MIM:603399 WNT1 inducible signaling pathway protein 2 WISP3 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:8838,Genbank:XM_011536222.2,HGNC:HGNC:12771,MIM:603400 WNT1 inducible signaling pathway protein 3 WIZ 2064.82023955872 1937.17066463456 2192.46981448288 1.13178970470136 0.178605919151225 0.214514126118572 1 8.33765 8.83498 10.2178 9.72879 GeneID:58525,Genbank:NM_021241.2,HGNC:HGNC:30917 widely interspaced zinc finger motifs GO:0003676,GO:0005634,GO:0005654,GO:0010571,GO:0030496,GO:0046872,GO:0050821,GO:0070062,GO:0070208,GO:0070984 nucleic acid binding|nucleus|nucleoplasm|positive regulation of nuclear cell cycle DNA replication|midbody|metal ion binding|protein stabilization|extracellular exosome|protein heterotrimerization|SET domain binding WLS 3193.52572899173 3253.54466885557 3133.50678912789 0.963105507394218 -0.0542342421388787 0.680180359938392 1 34.8648 36.6644 34.0431 35.5353 GeneID:79971,Genbank:XM_011542192.3,HGNC:HGNC:30238,MIM:611514 wntless Wnt ligand secretion mediator GO:0000139,GO:0001707,GO:0004871,GO:0005769,GO:0005789,GO:0005794,GO:0005802,GO:0005886,GO:0006886,GO:0009948,GO:0016021,GO:0016055,GO:0017147,GO:0030177,GO:0030666,GO:0030901,GO:0030902,GO:0031017,GO:0031410,GO:0031852,GO:0031901,GO:0032590,GO:0032839,GO:0043123,GO:0061355,GO:0061357,GO:0070062,GO:0090263 Golgi membrane|mesoderm formation|signal transducer activity|early endosome|endoplasmic reticulum membrane|Golgi apparatus|trans-Golgi network|plasma membrane|intracellular protein transport|anterior/posterior axis specification|integral component of membrane|Wnt signaling pathway|Wnt-protein binding|positive regulation of Wnt signaling pathway|endocytic vesicle membrane|midbrain development|hindbrain development|exocrine pancreas development|cytoplasmic vesicle|mu-type opioid receptor binding|early endosome membrane|dendrite membrane|dendrite cytoplasm|positive regulation of I-kappaB kinase/NF-kappaB signaling|Wnt protein secretion|positive regulation of Wnt protein secretion|extracellular exosome|positive regulation of canonical Wnt signaling pathway WNK1 2642.21613096754 2719.89244009445 2564.53982184063 0.942882808171477 -0.0848496268252458 0.701868567001334 1 7.53624 7.2845 8.35077 5.66559 GeneID:65125,Genbank:XM_011520997.3,HGNC:HGNC:14540,MIM:605232 WNK lysine deficient protein kinase 1 GO:0000287,GO:0002028,GO:0003084,GO:0004672,GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0006811,GO:0010766,GO:0010923,GO:0016020,GO:0018107,GO:0019869,GO:0019870,GO:0019901,GO:0019902,GO:0023016,GO:0030291,GO:0030295,GO:0035556,GO:0046777,GO:0048666,GO:0050794,GO:0071277,GO:0090188,GO:0090263 magnesium ion binding|regulation of sodium ion transport|positive regulation of systemic arterial blood pressure|protein kinase activity|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|protein phosphorylation|ion transport|negative regulation of sodium ion transport|negative regulation of phosphatase activity|membrane|peptidyl-threonine phosphorylation|chloride channel inhibitor activity|potassium channel inhibitor activity|protein kinase binding|phosphatase binding|signal transduction by trans-phosphorylation|protein serine/threonine kinase inhibitor activity|protein kinase activator activity|intracellular signal transduction|protein autophosphorylation|neuron development|regulation of cellular process|cellular response to calcium ion|negative regulation of pancreatic juice secretion|positive regulation of canonical Wnt signaling pathway WNK2 26.6622055673491 25.7042269649917 27.6201841697066 1.07453860438302 0.103717314642364 0.87973421847037 1 0.0753145 0.0599038 0.0967465 0.103638 GeneID:65268,Genbank:XM_005252141.2,HGNC:HGNC:14542,MIM:606249 WNK lysine deficient protein kinase 2 WNK3 36.6014662177423 35.3997937996611 37.8031386358236 1.06789149252574 0.0947650635536991 0.868845798824141 1 0.110387 0.116169 0.126953 0.0989668 GeneID:65267,Genbank:XM_017029744.1,HGNC:HGNC:14543,MIM:300358 WNK lysine deficient protein kinase 3 GO:0004672,GO:0004674,GO:0005524,GO:0005737,GO:0005829,GO:0005912,GO:0005923,GO:0006468,GO:0010765,GO:0010800,GO:0019869,GO:0032414,GO:0035556,GO:0043066,GO:0046777,GO:0051928,GO:0072659,GO:0090188,GO:0090279,GO:1903078,GO:2000021,GO:2000651,GO:2000682,GO:2000688 protein kinase activity|protein serine/threonine kinase activity|ATP binding|cytoplasm|cytosol|adherens junction|bicellular tight junction|protein phosphorylation|positive regulation of sodium ion transport|positive regulation of peptidyl-threonine phosphorylation|chloride channel inhibitor activity|positive regulation of ion transmembrane transporter activity|intracellular signal transduction|negative regulation of apoptotic process|protein autophosphorylation|positive regulation of calcium ion transport|protein localization to plasma membrane|negative regulation of pancreatic juice secretion|regulation of calcium ion import|positive regulation of protein localization to plasma membrane|regulation of ion homeostasis|positive regulation of sodium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of rubidium ion transmembrane transporter activity WNK4 5.5531985436012 5.77499561901052 5.33140146819188 0.92318710176015 -0.115305027269499 1 1 0.0513285 0.0223753 0.0316922 0.0222662 GeneID:65266,Genbank:XM_017024962.1,HGNC:HGNC:14544,MIM:601844 WNK lysine deficient protein kinase 4 GO:0004674,GO:0005524,GO:0005829,GO:0005923,GO:0006468,GO:0006811,GO:0006821,GO:0008104,GO:0010766,GO:0016020,GO:0019869,GO:0035556,GO:0050794,GO:0050801,GO:0070294,GO:0072156,GO:0090188 protein serine/threonine kinase activity|ATP binding|cytosol|bicellular tight junction|protein phosphorylation|ion transport|chloride transport|protein localization|negative regulation of sodium ion transport|membrane|chloride channel inhibitor activity|intracellular signal transduction|regulation of cellular process|ion homeostasis|renal sodium ion absorption|distal tubule morphogenesis|negative regulation of pancreatic juice secretion WNT10A 3.24456079029809 4.06465003971372 2.42447154088245 0.596477314699696 -0.745460824682868 0.730848732445383 1 0.0716249 0.101612 0.0873424 0.0204568 GeneID:80326,Genbank:XM_011511929.2,HGNC:HGNC:13829,MIM:606268 Wnt family member 10A GO:0001942,GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0010628,GO:0014033,GO:0016055,GO:0030182,GO:0031069,GO:0042476,GO:0042487,GO:0043586,GO:0043588,GO:0045165,GO:0048018,GO:0048730,GO:0048733,GO:0060070,GO:0071560 hair follicle development|frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|positive regulation of gene expression|neural crest cell differentiation|Wnt signaling pathway|neuron differentiation|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentin-containing tooth|tongue development|skin development|cell fate commitment|receptor ligand activity|epidermis morphogenesis|sebaceous gland development|canonical Wnt signaling pathway|cellular response to transforming growth factor beta stimulus hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT10B 8.71941186442159 8.71542403075469 8.72339969808849 1.00091512097468 0.00131963677039513 1 1 0.095061 0.0730745 0.077414 0.0826876 GeneID:7480,Genbank:XM_024449179.1,HGNC:HGNC:12775,MIM:601906 Wnt family member 10B GO:0000086,GO:0000122,GO:0002062,GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0006629,GO:0007050,GO:0007224,GO:0008284,GO:0010971,GO:0014835,GO:0016055,GO:0030182,GO:0030501,GO:0030858,GO:0032434,GO:0043065,GO:0045165,GO:0045599,GO:0045669,GO:0045899,GO:0048018,GO:0048641,GO:0048741,GO:0050680,GO:0050821,GO:0050909,GO:0051091,GO:0051885,GO:0060070,GO:0060346,GO:0061196,GO:0071300,GO:0071320,GO:0071374,GO:0071425,GO:0090263 G2/M transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|chondrocyte differentiation|frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|lipid metabolic process|cell cycle arrest|smoothened signaling pathway|positive regulation of cell proliferation|positive regulation of G2/M transition of mitotic cell cycle|myoblast differentiation involved in skeletal muscle regeneration|Wnt signaling pathway|neuron differentiation|positive regulation of bone mineralization|positive regulation of epithelial cell differentiation|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of apoptotic process|cell fate commitment|negative regulation of fat cell differentiation|positive regulation of osteoblast differentiation|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|receptor ligand activity|regulation of skeletal muscle tissue development|skeletal muscle fiber development|negative regulation of epithelial cell proliferation|protein stabilization|sensory perception of taste|positive regulation of DNA binding transcription factor activity|positive regulation of timing of anagen|canonical Wnt signaling pathway|bone trabecula formation|fungiform papilla development|cellular response to retinoic acid|cellular response to cAMP|cellular response to parathyroid hormone stimulus|hematopoietic stem cell proliferation|positive regulation of canonical Wnt signaling pathway hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT11 1.49172579352946 2.49838328447175 0.48506830258717 0.194152877023323 -2.3647350091371 0.504995494363966 1 0.0254168 0.0648977 0.0233906 0 GeneID:7481,Genbank:NM_004626.2,HGNC:HGNC:12776,MIM:603699 Wnt family member 11 GO:0001649,GO:0001837,GO:0003151,GO:0003402,GO:0005096,GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0005737,GO:0006468,GO:0007223,GO:0010628,GO:0016055,GO:0030182,GO:0030282,GO:0030295,GO:0030308,GO:0030325,GO:0030335,GO:0030336,GO:0031667,GO:0032915,GO:0034394,GO:0043065,GO:0043066,GO:0043547,GO:0044212,GO:0045165,GO:0045199,GO:0045892,GO:0045893,GO:0048341,GO:0048570,GO:0048706,GO:0048844,GO:0051496,GO:0060021,GO:0060028,GO:0060070,GO:0060071,GO:0060197,GO:0060412,GO:0060484,GO:0060548,GO:0060675,GO:0060775,GO:0061037,GO:0061053,GO:0061101,GO:0070830,GO:0071260,GO:0071300,GO:0072177,GO:0072201,GO:0090037,GO:0090090,GO:0090272 osteoblast differentiation|epithelial to mesenchymal transition|outflow tract morphogenesis|planar cell polarity pathway involved in axis elongation|GTPase activator activity|frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|protein phosphorylation|Wnt signaling pathway, calcium modulating pathway|positive regulation of gene expression|Wnt signaling pathway|neuron differentiation|bone mineralization|protein kinase activator activity|negative regulation of cell growth|adrenal gland development|positive regulation of cell migration|negative regulation of cell migration|response to nutrient levels|positive regulation of transforming growth factor beta2 production|protein localization to cell surface|positive regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of GTPase activity|transcription regulatory region DNA binding|cell fate commitment|maintenance of epithelial cell apical/basal polarity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|paraxial mesoderm formation|notochord morphogenesis|embryonic skeletal system development|artery morphogenesis|positive regulation of stress fiber assembly|palate development|convergent extension involved in axis elongation|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|cloacal septation|ventricular septum morphogenesis|lung-associated mesenchyme development|negative regulation of cell death|ureteric bud morphogenesis|planar cell polarity pathway involved in gastrula mediolateral intercalation|negative regulation of cartilage development|somite development|neuroendocrine cell differentiation|bicellular tight junction assembly|cellular response to mechanical stimulus|cellular response to retinoic acid|mesonephric duct development|negative regulation of mesenchymal cell proliferation|positive regulation of protein kinase C signaling|negative regulation of canonical Wnt signaling pathway|negative regulation of fibroblast growth factor production hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT16 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0272244 GeneID:51384,Genbank:NM_016087.2,HGNC:HGNC:16267,MIM:606267 Wnt family member 16 GO:0003408,GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0005737,GO:0010628,GO:0014068,GO:0016055,GO:0030182,GO:0030216,GO:0043616,GO:0045165,GO:0046330,GO:0046849,GO:0060317,GO:0060548,GO:0090399,GO:0090403 optic cup formation involved in camera-type eye development|frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|positive regulation of gene expression|positive regulation of phosphatidylinositol 3-kinase signaling|Wnt signaling pathway|neuron differentiation|keratinocyte differentiation|keratinocyte proliferation|cell fate commitment|positive regulation of JNK cascade|bone remodeling|cardiac epithelial to mesenchymal transition|negative regulation of cell death|replicative senescence|oxidative stress-induced premature senescence hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05202,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Transcriptional misregulation in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT2 0.484198330533773 0 0.968396661067546 Inf Inf 0.786481099255567 1 0 0 0 0.0275424 GeneID:7472,Genbank:NM_003391.2,HGNC:HGNC:12780,MIM:147870 Wnt family member 2 GO:0001938,GO:0002053,GO:0002088,GO:0005109,GO:0005125,GO:0005576,GO:0005578,GO:0005615,GO:0005737,GO:0007267,GO:0008284,GO:0016055,GO:0022008,GO:0030182,GO:0030324,GO:0031012,GO:0033278,GO:0045165,GO:0045944,GO:0048018,GO:0048146,GO:0051091,GO:0055009,GO:0060045,GO:0060070,GO:0060317,GO:0060492,GO:0060501,GO:0060716,GO:0061072,GO:0061180,GO:0071300,GO:0071560,GO:0090263,GO:1904948,GO:1904954,GO:1990909 positive regulation of endothelial cell proliferation|positive regulation of mesenchymal cell proliferation|lens development in camera-type eye|frizzled binding|cytokine activity|extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|cell-cell signaling|positive regulation of cell proliferation|Wnt signaling pathway|neurogenesis|neuron differentiation|lung development|extracellular matrix|cell proliferation in midbrain|cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|receptor ligand activity|positive regulation of fibroblast proliferation|positive regulation of DNA binding transcription factor activity|atrial cardiac muscle tissue morphogenesis|positive regulation of cardiac muscle cell proliferation|canonical Wnt signaling pathway|cardiac epithelial to mesenchymal transition|lung induction|positive regulation of epithelial cell proliferation involved in lung morphogenesis|labyrinthine layer blood vessel development|iris morphogenesis|mammary gland epithelium development|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|positive regulation of canonical Wnt signaling pathway|midbrain dopaminergic neuron differentiation|canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|Wnt signalosome hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT2B 17.3045103495985 14.7403596782979 19.8686610208992 1.34790883360545 0.430722922518953 0.565460871613818 1 0.135951 0.208459 0.23019 0.261821 GeneID:7482,Genbank:NM_004185.4,HGNC:HGNC:12781,MIM:601968 Wnt family member 2B GO:0002062,GO:0002088,GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0008584,GO:0009267,GO:0016055,GO:0021871,GO:0030182,GO:0043231,GO:0045165,GO:0060070,GO:0060492,GO:0060638,GO:0061072,GO:0061303,GO:0071425,GO:0090190,GO:0090263 chondrocyte differentiation|lens development in camera-type eye|frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|male gonad development|cellular response to starvation|Wnt signaling pathway|forebrain regionalization|neuron differentiation|intracellular membrane-bounded organelle|cell fate commitment|canonical Wnt signaling pathway|lung induction|mesenchymal-epithelial cell signaling|iris morphogenesis|cornea development in camera-type eye|hematopoietic stem cell proliferation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt signaling pathway hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT3 247.412547740544 260.75111845662 234.073977024467 0.897691171604349 -0.155708888033963 0.487692021842624 1 3.68042 3.06317 2.96046 2.86034 GeneID:7473,Genbank:NM_030753.4,HGNC:HGNC:12782,MIM:165330 Wnt family member 3 GO:0000902,GO:0001707,GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0007276,GO:0007411,GO:0009948,GO:0009950,GO:0010628,GO:0016055,GO:0019904,GO:0030177,GO:0030182,GO:0030666,GO:0035115,GO:0035116,GO:0044338,GO:0044339,GO:0045165,GO:0048018,GO:0048697,GO:0048843,GO:0050767,GO:0060064,GO:0060070,GO:0060174,GO:0060323,GO:0061180,GO:0070062,GO:0071300,GO:0072089,GO:1904954,GO:1905474,GO:1990909 cell morphogenesis|mesoderm formation|frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|gamete generation|axon guidance|anterior/posterior axis specification|dorsal/ventral axis specification|positive regulation of gene expression|Wnt signaling pathway|protein domain specific binding|positive regulation of Wnt signaling pathway|neuron differentiation|endocytic vesicle membrane|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt signaling pathway involved in osteoblast differentiation|cell fate commitment|receptor ligand activity|positive regulation of collateral sprouting in absence of injury|negative regulation of axon extension involved in axon guidance|regulation of neurogenesis|Spemann organizer formation at the anterior end of the primitive streak|canonical Wnt signaling pathway|limb bud formation|head morphogenesis|mammary gland epithelium development|extracellular exosome|cellular response to retinoic acid|stem cell proliferation|canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|canonical Wnt signaling pathway involved in stem cell proliferation|Wnt signalosome hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05206,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|MicroRNAs in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT4 1.29134484549723 1.61429302992691 0.968396661067546 0.599889018359566 -0.737232473286342 0.974655394057561 1 0 0 0 0.00509618 GeneID:54361,Genbank:NM_030761.4,HGNC:HGNC:12783,MIM:603490 Wnt family member 4 GO:0001658,GO:0001822,GO:0001837,GO:0001838,GO:0001889,GO:0003714,GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0005737,GO:0005788,GO:0005796,GO:0005886,GO:0006702,GO:0008584,GO:0008585,GO:0009267,GO:0009986,GO:0010629,GO:0010894,GO:0016055,GO:0022407,GO:0030182,GO:0030237,GO:0030325,GO:0030336,GO:0030501,GO:0030666,GO:0032349,GO:0032967,GO:0033080,GO:0038030,GO:0040037,GO:0043547,GO:0045165,GO:0045596,GO:0045669,GO:0045836,GO:0045892,GO:0045893,GO:0048018,GO:0048599,GO:0051145,GO:0051496,GO:0051894,GO:0060070,GO:0060126,GO:0060129,GO:0060231,GO:0060748,GO:0061045,GO:0061180,GO:0061184,GO:0061205,GO:0061369,GO:0070062,GO:0071560,GO:0072033,GO:0072034,GO:0072162,GO:0072174,GO:0072273,GO:0072659,GO:0090090,GO:0090263,GO:2000019,GO:2000066,GO:2000225,GO:2001234 branching involved in ureteric bud morphogenesis|kidney development|epithelial to mesenchymal transition|embryonic epithelial tube formation|liver development|transcription corepressor activity|frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|cytoplasm|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|androgen biosynthetic process|male gonad development|female gonad development|cellular response to starvation|cell surface|negative regulation of gene expression|negative regulation of steroid biosynthetic process|Wnt signaling pathway|regulation of cell-cell adhesion|neuron differentiation|female sex determination|adrenal gland development|negative regulation of cell migration|positive regulation of bone mineralization|endocytic vesicle membrane|positive regulation of aldosterone biosynthetic process|positive regulation of collagen biosynthetic process|immature T cell proliferation in thymus|non-canonical Wnt signaling pathway via MAPK cascade|negative regulation of fibroblast growth factor receptor signaling pathway|positive regulation of GTPase activity|cell fate commitment|negative regulation of cell differentiation|positive regulation of osteoblast differentiation|positive regulation of meiotic nuclear division|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|receptor ligand activity|oocyte development|smooth muscle cell differentiation|positive regulation of stress fiber assembly|positive regulation of focal adhesion assembly|canonical Wnt signaling pathway|somatotropin secreting cell differentiation|thyroid-stimulating hormone-secreting cell differentiation|mesenchymal to epithelial transition|tertiary branching involved in mammary gland duct morphogenesis|negative regulation of wound healing|mammary gland epithelium development|positive regulation of dermatome development|paramesonephric duct development|negative regulation of testicular blood vessel morphogenesis|extracellular exosome|cellular response to transforming growth factor beta stimulus|renal vesicle formation|renal vesicle induction|metanephric mesenchymal cell differentiation|metanephric tubule formation|metanephric nephron morphogenesis|protein localization to plasma membrane|negative regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|negative regulation of male gonad development|positive regulation of cortisol biosynthetic process|negative regulation of testosterone biosynthetic process|negative regulation of apoptotic signaling pathway hsa04150,hsa04310,hsa04360,hsa04390,hsa04550,hsa04916,hsa04919,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Thyroid hormone signaling pathway|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT5A 359.717744737103 403.436297663657 315.999191810549 0.783269114952061 -0.352420022234797 0.06533358218333 0.901277047586747 1.10088 1.06194 0.889043 0.774631 GeneID:7474,Genbank:XM_017007127.1,HGNC:HGNC:12784,MIM:164975 Wnt family member 5A hsa04150,hsa04310,hsa04360,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT5B 554.154035690604 448.705163087366 659.602908293843 1.47001408175331 0.555829975182973 0.00117751931874918 0.11360933378968 5.93562 6.0412 9.51451 8.39007 GeneID:81029,Genbank:XM_024449207.1,HGNC:HGNC:16265,MIM:606361 Wnt family member 5B GO:0002062,GO:0005102,GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0009986,GO:0016055,GO:0030182,GO:0030335,GO:0030666,GO:0042060,GO:0045165,GO:0045444,GO:0045600,GO:0070062,GO:0070307,GO:0071300,GO:0090090 chondrocyte differentiation|receptor binding|frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|cell surface|Wnt signaling pathway|neuron differentiation|positive regulation of cell migration|endocytic vesicle membrane|wound healing|cell fate commitment|fat cell differentiation|positive regulation of fat cell differentiation|extracellular exosome|lens fiber cell development|cellular response to retinoic acid|negative regulation of canonical Wnt signaling pathway hsa04150,hsa04310,hsa04360,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Axon guidance|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT6 5.20830378548744 4.60274771635603 5.81385985461886 1.26312807325049 0.337000926754712 0.871802572746441 1 0.233529 0.32945 0.209879 0.294194 GeneID:7475,Genbank:NM_006522.3,HGNC:HGNC:12785,MIM:604663 Wnt family member 6 GO:0001658,GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0009798,GO:0009986,GO:0010628,GO:0016055,GO:0030182,GO:0030666,GO:0042475,GO:0045165,GO:0045893,GO:0060684,GO:0061303,GO:0070062,GO:0070172,GO:0071300,GO:0072079 branching involved in ureteric bud morphogenesis|frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|axis specification|cell surface|positive regulation of gene expression|Wnt signaling pathway|neuron differentiation|endocytic vesicle membrane|odontogenesis of dentin-containing tooth|cell fate commitment|positive regulation of transcription, DNA-templated|epithelial-mesenchymal cell signaling|cornea development in camera-type eye|extracellular exosome|positive regulation of tooth mineralization|cellular response to retinoic acid|nephron tubule formation hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT7B 24.9240532491395 26.5883172195365 23.2597892787424 0.874812387963074 -0.192954444773016 0.756937000234433 1 0.288136 0.303919 0.241336 0.271254 GeneID:7477,Genbank:XM_011530366.1,HGNC:HGNC:12787,MIM:601967 Wnt family member 7B GO:0001701,GO:0003338,GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0005788,GO:0005796,GO:0005886,GO:0007257,GO:0016055,GO:0016332,GO:0021871,GO:0022009,GO:0030182,GO:0030324,GO:0030666,GO:0032364,GO:0032536,GO:0042592,GO:0044237,GO:0045165,GO:0045669,GO:0048018,GO:0048144,GO:0048568,GO:0048812,GO:0050808,GO:0051384,GO:0060070,GO:0060425,GO:0060428,GO:0060482,GO:0060535,GO:0060560,GO:0060669,GO:0060710,GO:0061180,GO:0070062,GO:0070307,GO:0071300,GO:0072053,GO:0072054,GO:0072060,GO:0072061,GO:0072089,GO:0072205,GO:0072207,GO:0072236 in utero embryonic development|metanephros morphogenesis|frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|endoplasmic reticulum lumen|Golgi lumen|plasma membrane|activation of JUN kinase activity|Wnt signaling pathway|establishment or maintenance of polarity of embryonic epithelium|forebrain regionalization|central nervous system vasculogenesis|neuron differentiation|lung development|endocytic vesicle membrane|oxygen homeostasis|regulation of cell projection size|homeostatic process|cellular metabolic process|cell fate commitment|positive regulation of osteoblast differentiation|receptor ligand activity|fibroblast proliferation|embryonic organ development|neuron projection morphogenesis|synapse organization|response to glucocorticoid|canonical Wnt signaling pathway|lung morphogenesis|lung epithelium development|lobar bronchus development|trachea cartilage morphogenesis|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|chorio-allantoic fusion|mammary gland epithelium development|extracellular exosome|lens fiber cell development|cellular response to retinoic acid|renal inner medulla development|renal outer medulla development|outer medullary collecting duct development|inner medullary collecting duct development|stem cell proliferation|metanephric collecting duct development|metanephric epithelium development|metanephric loop of Henle development hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT8A 0.729234031512454 0.490071401957362 0.968396661067546 1.97603177251261 0.982606144127986 1 1 0 0.0100632 0 0.0190554 GeneID:7478,Genbank:XM_017009826.1,HGNC:HGNC:12788,MIM:606360 Wnt family member 8A GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0014034,GO:0016055,GO:0030182,GO:0032526,GO:0044324,GO:0044335,GO:0048018,GO:0060021,GO:0060070,GO:0061317,GO:1904886 frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|neural crest cell fate commitment|Wnt signaling pathway|neuron differentiation|response to retinoic acid|regulation of transcription involved in anterior/posterior axis specification|canonical Wnt signaling pathway involved in neural crest cell differentiation|receptor ligand activity|palate development|canonical Wnt signaling pathway|canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|beta-catenin destruction complex disassembly hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT8B 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0279892 0 GeneID:7479,Genbank:NM_003393.3,HGNC:HGNC:12789,MIM:601396 Wnt family member 8B GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0007165,GO:0007369,GO:0007399,GO:0016055,GO:0030182,GO:0032355,GO:0032526,GO:0045165,GO:0048018,GO:0048263,GO:0060070,GO:0071300,GO:1904886 frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|signal transduction|gastrulation|nervous system development|Wnt signaling pathway|neuron differentiation|response to estradiol|response to retinoic acid|cell fate commitment|receptor ligand activity|determination of dorsal identity|canonical Wnt signaling pathway|cellular response to retinoic acid|beta-catenin destruction complex disassembly hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WNT9A 8.30224984654504 7.8793600508948 8.72513964219528 1.10734115281411 0.147099760194702 0.921006526521332 1 0.152981 0.0483214 0.0905794 0.0722657 GeneID:7483,Genbank:NM_003395.3,HGNC:HGNC:12778,MIM:602863 Wnt family member 9A GO:0005109,GO:0005576,GO:0005578,GO:0005615,GO:0007093,GO:0007267,GO:0007275,GO:0008285,GO:0016055,GO:0030182,GO:0032331,GO:0035115,GO:0043154,GO:0045165,GO:0045597,GO:0045880,GO:0048018,GO:0048704,GO:0060070,GO:0061072,GO:0061303,GO:0070062,GO:0071300,GO:0072498 frizzled binding|extracellular region|proteinaceous extracellular matrix|extracellular space|mitotic cell cycle checkpoint|cell-cell signaling|multicellular organism development|negative regulation of cell proliferation|Wnt signaling pathway|neuron differentiation|negative regulation of chondrocyte differentiation|embryonic forelimb morphogenesis|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|cell fate commitment|positive regulation of cell differentiation|positive regulation of smoothened signaling pathway|receptor ligand activity|embryonic skeletal system morphogenesis|canonical Wnt signaling pathway|iris morphogenesis|cornea development in camera-type eye|extracellular exosome|cellular response to retinoic acid|embryonic skeletal joint development hsa04150,hsa04310,hsa04390,hsa04550,hsa04916,hsa04934,hsa05165,hsa05166,hsa05200,hsa05205,hsa05217,hsa05224,hsa05225,hsa05226 mTOR signaling pathway|Wnt signaling pathway|Hippo signaling pathway|Signaling pathways regulating pluripotency of stem cells|Melanogenesis|Cushing syndrome|Human papillomavirus infection|Human T-cell leukemia virus 1 infection|Pathways in cancer|Proteoglycans in cancer|Basal cell carcinoma|Breast cancer|Hepatocellular carcinoma|Gastric cancer WRAP53 828.195637839931 836.47000154435 819.921274135512 0.9802159941441 -0.0288284075519338 0.853721322274544 1 6.91315 7.80901 6.85121 8.17124 GeneID:55135,Genbank:NM_001143990.1,HGNC:HGNC:25522,MIM:612661 WD repeat containing antisense to TP53 WRAP73 702.946158131237 724.562251110402 681.330065152071 0.940333372471342 -0.0887557747506571 0.580797216821519 1 18.0123 17.9116 16.0727 18.2329 GeneID:49856,Genbank:NM_017818.3,HGNC:HGNC:12759,MIM:606040 WD repeat containing, antisense to TP73 GO:0005813,GO:0005814,GO:0030030,GO:0036064,GO:0090307,GO:1902857 centrosome|centriole|cell projection organization|ciliary basal body|mitotic spindle assembly|positive regulation of non-motile cilium assembly WRB 284.464301047929 291.269815546923 277.658786548934 0.953270032555789 -0.0690431510075989 0.757761245785692 1 11.1219 10.9487 9.21794 11.5321 GeneID:7485,Genbank:NM_004627.5,HGNC:HGNC:12790,MIM:602915 tryptophan rich basic protein GO:0005789,GO:0016021,GO:0071816 endoplasmic reticulum membrane|integral component of membrane|tail-anchored membrane protein insertion into ER membrane WRN 224.563659840548 244.588570847135 204.538748833961 0.836256363596789 -0.257982810724177 0.347246723026844 1 1.23956 0.966156 1.09813 0.766024 GeneID:7486,Genbank:NM_000553.5,HGNC:HGNC:12791,MIM:604611 Werner syndrome RecQ like helicase WRNIP1 2249.65376793612 2324.75218964706 2174.55534622518 0.935392320914567 -0.0963565098593385 0.473297216372061 1 34.4783 37.1764 35.8118 33.4112 GeneID:56897,Genbank:XM_005249232.3,HGNC:HGNC:20876,MIM:608196 Werner helicase interacting protein 1 GO:0000731,GO:0003677,GO:0005524,GO:0005634,GO:0006260,GO:0016020,GO:0016887,GO:0030174,GO:0042802,GO:0045087,GO:0046872,GO:0048471 DNA synthesis involved in DNA repair|DNA binding|ATP binding|nucleus|DNA replication|membrane|ATPase activity|regulation of DNA-dependent DNA replication initiation|identical protein binding|innate immune response|metal ion binding|perinuclear region of cytoplasm WSB1 1188.12774636005 1265.42721272851 1110.82827999159 0.877828664357885 -0.187988714582966 0.208304742833321 1 11.7021 12.6558 11.8614 9.8844 GeneID:26118,Genbank:NM_015626.9,HGNC:HGNC:19221,MIM:610091 WD repeat and SOCS box containing 1 GO:0000209,GO:0004842,GO:0005622,GO:0005829,GO:0035556,GO:0043687 protein polyubiquitination|ubiquitin-protein transferase activity|intracellular|cytosol|intracellular signal transduction|post-translational protein modification WSB2 4801.69772861152 4967.3496524029 4636.04580482014 0.933303699001237 -0.0995814813895225 0.450646527096607 1 73.5358 75.9827 67.6224 66.9276 GeneID:55884,Genbank:NM_001278557.1,HGNC:HGNC:19222 WD repeat and SOCS box containing 2 GO:0005829,GO:0016567,GO:0035556,GO:0043687 cytosol|protein ubiquitination|intracellular signal transduction|post-translational protein modification WSCD1 1291.75825958955 1153.35881716286 1430.15770201624 1.23999373025498 0.310332825972704 0.0390843673170116 0.753859521009372 4.03143 4.8135 5.82812 5.44756 GeneID:23302,Genbank:XM_005256573.1,HGNC:HGNC:29060 WSC domain containing 1 GO:0008146,GO:0016021 sulfotransferase activity|integral component of membrane WT1 2.50738712370365 2.10436443188427 2.91040981552302 1.38303507293031 0.467837742823213 0.915367287152001 1 0.031509 0.0141893 0.0887587 0 GeneID:7490,Genbank:NM_000378.5,HGNC:HGNC:12796,MIM:607102 Wilms tumor 1 hsa05202 Transcriptional misregulation in cancer WTAP 2028.34823217943 2230.6094371957 1826.08702716316 0.818649377480845 -0.288682408196327 0.0403952182390011 0.758464027333929 15.9979 16.7482 14.2182 13.2932 GeneID:9589,Genbank:XM_017011514.2,HGNC:HGNC:16846,MIM:605442 WT1 associated protein GO:0000381,GO:0005634,GO:0005654,GO:0006397,GO:0007049,GO:0008380,GO:0016070,GO:0016607,GO:0031965,GO:0036396,GO:0080009 regulation of alternative mRNA splicing, via spliceosome|nucleus|nucleoplasm|mRNA processing|cell cycle|RNA splicing|RNA metabolic process|nuclear speck|nuclear membrane|RNA N6-methyladenosine methyltransferase complex|mRNA methylation WTIP 196.13629555421 189.212536427662 203.060054680757 1.07318499352388 0.101898786472116 0.692786364999723 1 2.68237 2.87688 3.39226 3.1473 GeneID:126374,Genbank:XM_011526452.3,HGNC:HGNC:20964,MIM:614790 WT1 interacting protein GO:0000932,GO:0001666,GO:0003714,GO:0005634,GO:0005667,GO:0005911,GO:0005912,GO:0006351,GO:0006355,GO:0007010,GO:0022604,GO:0030030,GO:0035195,GO:0035331,GO:0046872,GO:2000637 P-body|response to hypoxia|transcription corepressor activity|nucleus|transcription factor complex|cell-cell junction|adherens junction|transcription, DNA-templated|regulation of transcription, DNA-templated|cytoskeleton organization|regulation of cell morphogenesis|cell projection organization|gene silencing by miRNA|negative regulation of hippo signaling|metal ion binding|positive regulation of gene silencing by miRNA hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species WWC1 758.972118033229 845.761740871324 672.182495195134 0.794765786523561 -0.331398326823186 0.0365110448788029 0.739899327172153 3.28228 3.45541 2.83534 2.70689 GeneID:23286,Genbank:NM_001161661.1,HGNC:HGNC:29435,MIM:610533 WW and C2 domain containing 1 GO:0000122,GO:0003713,GO:0005634,GO:0005737,GO:0005829,GO:0006351,GO:0007221,GO:0016477,GO:0019900,GO:0030010,GO:0030674,GO:0032386,GO:0032587,GO:0032947,GO:0035329,GO:0035330,GO:0035331,GO:0043234,GO:0043410,GO:0046621,GO:0048471 negative regulation of transcription from RNA polymerase II promoter|transcription coactivator activity|nucleus|cytoplasm|cytosol|transcription, DNA-templated|positive regulation of transcription of Notch receptor target|cell migration|kinase binding|establishment of cell polarity|protein binding, bridging|regulation of intracellular transport|ruffle membrane|protein complex scaffold activity|hippo signaling|regulation of hippo signaling|negative regulation of hippo signaling|protein complex|positive regulation of MAPK cascade|negative regulation of organ growth|perinuclear region of cytoplasm hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species WWC2 1129.2782769206 1269.29772366778 989.258830173424 0.779374934443947 -0.359610561295362 0.123629544812713 1 5.22633 4.57286 4.53876 3.21772 GeneID:80014,Genbank:XM_011532269.3,HGNC:HGNC:24148 WW and C2 domain containing 2 GO:0000122,GO:0005829,GO:0019900,GO:0032947,GO:0035331,GO:0046621 negative regulation of transcription from RNA polymerase II promoter|cytosol|kinase binding|protein complex scaffold activity|negative regulation of hippo signaling|negative regulation of organ growth WWC3 1359.14969281843 1392.27825359546 1326.0211320414 0.952411005930062 -0.0703438025981233 0.611581640007004 1 8.28107 9.07522 9.20073 7.65801 GeneID:55841,Genbank:NM_015691.3,HGNC:HGNC:29237 WWC family member 3 GO:0000122,GO:0005829,GO:0019900,GO:0032947,GO:0035331,GO:0046621 negative regulation of transcription from RNA polymerase II promoter|cytosol|kinase binding|protein complex scaffold activity|negative regulation of hippo signaling|negative regulation of organ growth WWOX 423.123755687397 417.331801707842 428.915709666952 1.02775706982239 0.0394992960688436 0.85348181964907 1 2.02749 2.38056 2.51189 2.12008 GeneID:51741,Genbank:NM_016373.3,HGNC:HGNC:12799,MIM:605131 WW domain containing oxidoreductase WWP1 172.940140762283 190.307332090308 155.572949434258 0.817482688267802 -0.290739915731862 0.234175900590689 1 1.51119 1.5299 1.39742 1.1549 GeneID:11059,Genbank:XM_005250760.4,HGNC:HGNC:17004,MIM:602307 WW domain containing E3 ubiquitin protein ligase 1 hsa04120,hsa04144 Ubiquitin mediated proteolysis|Endocytosis WWP2 1442.40591564252 1327.6662807771 1557.14555050794 1.17284408970342 0.230011243578298 0.118082562516265 1 5.42624 5.98159 7.02918 6.54418 GeneID:11060,Genbank:NM_007014.4,HGNC:HGNC:16804,MIM:602308 WW domain containing E3 ubiquitin protein ligase 2 GO:0000122,GO:0000151,GO:0001085,GO:0001190,GO:0004842,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006858,GO:0008134,GO:0010629,GO:0016020,GO:0016567,GO:0032410,GO:0034765,GO:0042391,GO:0042787,GO:0043161,GO:0043433,GO:0045746,GO:0045892,GO:0046718,GO:0051224,GO:0051865,GO:0061630,GO:0070062,GO:0070534,GO:1901016 negative regulation of transcription from RNA polymerase II promoter|ubiquitin ligase complex|RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II transcription factor binding|ubiquitin-protein transferase activity|nucleus|cytoplasm|cytosol|cellular protein modification process|extracellular transport|transcription factor binding|negative regulation of gene expression|membrane|protein ubiquitination|negative regulation of transporter activity|regulation of ion transmembrane transport|regulation of membrane potential|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|negative regulation of DNA binding transcription factor activity|negative regulation of Notch signaling pathway|negative regulation of transcription, DNA-templated|viral entry into host cell|negative regulation of protein transport|protein autoubiquitination|ubiquitin protein ligase activity|extracellular exosome|protein K63-linked ubiquitination|regulation of potassium ion transmembrane transporter activity hsa04120 Ubiquitin mediated proteolysis WWTR1 2066.07491485894 2065.97487210335 2066.17495761453 1.00009684798875 0.000139715347626224 0.978071871599737 1 15.3982 13.5314 16.7012 12.7511 GeneID:25937,Genbank:NM_001348362.1,HGNC:HGNC:24042,MIM:607392 WW domain containing transcription regulator 1 GO:0000122,GO:0001649,GO:0001933,GO:0003713,GO:0003714,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0005829,GO:0006355,GO:0006367,GO:0006469,GO:0008284,GO:0010718,GO:0016567,GO:0016604,GO:0017145,GO:0031146,GO:0032835,GO:0035264,GO:0035329,GO:0035414,GO:0042803,GO:0045599,GO:0045944,GO:0048762,GO:0060271,GO:0060390,GO:0060993,GO:0072307,GO:0090090 negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|negative regulation of protein phosphorylation|transcription coactivator activity|transcription corepressor activity|nucleus|nucleoplasm|transcription factor complex|cytoplasm|cytosol|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|negative regulation of protein kinase activity|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|protein ubiquitination|nuclear body|stem cell division|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|glomerulus development|multicellular organism growth|hippo signaling|negative regulation of catenin import into nucleus|protein homodimerization activity|negative regulation of fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|mesenchymal cell differentiation|cilium assembly|regulation of SMAD protein import into nucleus|kidney morphogenesis|regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of canonical Wnt signaling pathway hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species XAB2 1482.38011611765 1460.07078619899 1504.68944603631 1.0305592442908 0.0434274442150866 0.80803448117777 1 20.6271 21.7818 21.1276 22.4437 GeneID:56949,Genbank:NM_020196.2,HGNC:HGNC:14089,MIM:610850 XPA binding protein 2 hsa03040 Spliceosome XAF1 7.58409581258175 3.52655236307142 11.6416392620921 3.30113892083341 1.72296385233817 0.550673749348103 1 0.0112628 0.0263931 0.112855 0 GeneID:54739,Genbank:XM_024450809.1,HGNC:HGNC:30932,MIM:606717 XIAP associated factor 1 GO:0003964,GO:0006310,GO:0009036,GO:0032197,GO:0032199,GO:0046872,GO:0090305 RNA-directed DNA polymerase activity|DNA recombination|Type II site-specific deoxyribonuclease activity|transposition, RNA-mediated|reverse transcription involved in RNA-mediated transposition|metal ion binding|nucleic acid phosphodiester bond hydrolysis XBP1 1664.26141632634 1670.21028008506 1658.31255256763 0.992876509228037 -0.0103138037231396 0.932631437747291 1 36.1938 39.2492 35.7506 38.5756 GeneID:7494,Genbank:NM_001079539.1,HGNC:HGNC:12801,MIM:194355 X-box binding protein 1 GO:0000122,GO:0000977,GO:0000981,GO:0001047,GO:0001085,GO:0001158,GO:0001525,GO:0001889,GO:0001934,GO:0001935,GO:0002020,GO:0002639,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005829,GO:0006366,GO:0006511,GO:0006633,GO:0006914,GO:0006955,GO:0006990,GO:0006996,GO:0007517,GO:0008284,GO:0010506,GO:0010508,GO:0010832,GO:0014065,GO:0015031,GO:0016021,GO:0016049,GO:0019901,GO:0030176,GO:0030331,GO:0030335,GO:0030512,GO:0030968,GO:0031017,GO:0031062,GO:0031490,GO:0031625,GO:0031647,GO:0031648,GO:0031670,GO:0032008,GO:0032869,GO:0034599,GO:0034976,GO:0035356,GO:0035470,GO:0035924,GO:0036498,GO:0036500,GO:0042149,GO:0042632,GO:0042803,GO:0042993,GO:0043066,GO:0044212,GO:0045348,GO:0045579,GO:0045582,GO:0045600,GO:0045766,GO:0045944,GO:0046982,GO:0048010,GO:0048666,GO:0051024,GO:0051897,GO:0055089,GO:0055092,GO:0060394,GO:0060612,GO:0060691,GO:0070059,GO:0070373,GO:0071222,GO:0071230,GO:0071332,GO:0071333,GO:0071353,GO:0071375,GO:0071498,GO:0071499,GO:1900100,GO:1900102,GO:1900103,GO:1900413,GO:1901800,GO:1901985,GO:1902236,GO:1903071,GO:1903489,GO:1904707,GO:1904754,GO:1990418,GO:1990440,GO:1990830,GO:2000347,GO:2000353,GO:2000778 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|core promoter binding|RNA polymerase II transcription factor binding|enhancer sequence-specific DNA binding|angiogenesis|liver development|positive regulation of protein phosphorylation|endothelial cell proliferation|protease binding|positive regulation of immunoglobulin production|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|cytosol|transcription from RNA polymerase II promoter|ubiquitin-dependent protein catabolic process|fatty acid biosynthetic process|autophagy|immune response|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|organelle organization|muscle organ development|positive regulation of cell proliferation|regulation of autophagy|positive regulation of autophagy|negative regulation of myotube differentiation|phosphatidylinositol 3-kinase signaling|protein transport|integral component of membrane|cell growth|protein kinase binding|integral component of endoplasmic reticulum membrane|estrogen receptor binding|positive regulation of cell migration|negative regulation of transforming growth factor beta receptor signaling pathway|endoplasmic reticulum unfolded protein response|exocrine pancreas development|positive regulation of histone methylation|chromatin DNA binding|ubiquitin protein ligase binding|regulation of protein stability|protein destabilization|cellular response to nutrient|positive regulation of TOR signaling|cellular response to insulin stimulus|cellular response to oxidative stress|response to endoplasmic reticulum stress|cellular triglyceride homeostasis|positive regulation of vascular wound healing|cellular response to vascular endothelial growth factor stimulus|IRE1-mediated unfolded protein response|ATF6-mediated unfolded protein response|cellular response to glucose starvation|cholesterol homeostasis|protein homodimerization activity|positive regulation of transcription factor import into nucleus|negative regulation of apoptotic process|transcription regulatory region DNA binding|positive regulation of MHC class II biosynthetic process|positive regulation of B cell differentiation|positive regulation of T cell differentiation|positive regulation of fat cell differentiation|positive regulation of angiogenesis|positive regulation of transcription from RNA polymerase II promoter|protein heterodimerization activity|vascular endothelial growth factor receptor signaling pathway|neuron development|positive regulation of immunoglobulin secretion|positive regulation of protein kinase B signaling|fatty acid homeostasis|sterol homeostasis|negative regulation of pathway-restricted SMAD protein phosphorylation|adipose tissue development|epithelial cell maturation involved in salivary gland development|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|negative regulation of ERK1 and ERK2 cascade|cellular response to lipopolysaccharide|cellular response to amino acid stimulus|cellular response to fructose stimulus|cellular response to glucose stimulus|cellular response to interleukin-4|cellular response to peptide hormone stimulus|cellular response to fluid shear stress|cellular response to laminar fluid shear stress|positive regulation of plasma cell differentiation|negative regulation of endoplasmic reticulum unfolded protein response|positive regulation of endoplasmic reticulum unfolded protein response|positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter|positive regulation of proteasomal protein catabolic process|positive regulation of protein acetylation|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|positive regulation of lactation|positive regulation of vascular smooth muscle cell proliferation|positive regulation of vascular associated smooth muscle cell migration|response to insulin-like growth factor stimulus|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|cellular response to leukemia inhibitory factor|positive regulation of hepatocyte proliferation|positive regulation of endothelial cell apoptotic process|positive regulation of interleukin-6 secretion hsa04141,hsa04932,hsa05166 Protein processing in endoplasmic reticulum|Non-alcoholic fatty liver disease (NAFLD)|Human T-cell leukemia virus 1 infection XDH 8.07015688001854 9.83964565872424 6.30066810131283 0.640334857559265 -0.643101547583554 0.57521844237763 1 0.0425045 0.0335231 0.0230481 0.0214525 GeneID:7498,Genbank:XM_011533095.2,HGNC:HGNC:12805,MIM:607633 xanthine dehydrogenase hsa00230,hsa00232,hsa00983,hsa04146 Purine metabolism|Caffeine metabolism|Drug metabolism - other enzymes|Peroxisome XG 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0290233 GeneID:7499,Genbank:XM_017029787.2,HGNC:HGNC:12806,MIM:300879 Xg blood group XIAP 943.784550693037 1093.20246223423 794.366639151843 0.726641831311244 -0.460683673686478 0.005858490658179 0.305633831861221 6.02652 5.41228 4.66366 3.77253 GeneID:331,Genbank:NM_001204401.1,HGNC:HGNC:592,MIM:300079 X-linked inhibitor of apoptosis hsa01524,hsa04064,hsa04120,hsa04210,hsa04215,hsa04217,hsa04510,hsa04621,hsa05145,hsa05166,hsa05200,hsa05222 Platinum drug resistance|NF-kappa B signaling pathway|Ubiquitin mediated proteolysis|Apoptosis|Apoptosis - multiple species|Necroptosis|Focal adhesion|NOD-like receptor signaling pathway|Toxoplasmosis|Human T-cell leukemia virus 1 infection|Pathways in cancer|Small cell lung cancer XIRP1 1.45727147141991 0.490071401957362 2.42447154088245 4.94718020924916 2.30660645301479 0.553915308546872 1 0 0.00461206 0.0195008 0.00457473 GeneID:165904,Genbank:NM_001351377.1,HGNC:HGNC:14301,MIM:609777 xin actin binding repeat containing 1 GO:0003723,GO:0003779,GO:0007507,GO:0030036,GO:0030054,GO:0032091 RNA binding|actin binding|heart development|actin cytoskeleton organization|cell junction|negative regulation of protein binding XIRP2 0.759120240278514 1.51824048055703 0 0 -Inf 0.560179495762059 1 0.00221044 0.00429966 0 0 GeneID:129446,Genbank:NM_001199143.1,HGNC:HGNC:14303,MIM:609778 xin actin binding repeat containing 2 GO:0001725,GO:0003281,GO:0003779,GO:0005925,GO:0030018,GO:0030036,GO:0031941,GO:0045216,GO:0046872,GO:0051393,GO:0055008 stress fiber|ventricular septum development|actin binding|focal adhesion|Z disc|actin cytoskeleton organization|filamentous actin|cell-cell junction organization|metal ion binding|alpha-actinin binding|cardiac muscle tissue morphogenesis XK 71.7392928533827 82.8876765139855 60.5909091927798 0.731000213072162 -0.452056268192405 0.195413081288565 1 0.318154 0.29667 0.299033 0.165293 GeneID:7504,Genbank:XM_011543978.3,HGNC:HGNC:12811,MIM:314850 X-linked Kx blood group XKR3 7.04405436507727 8.27337890348227 5.81472982667226 0.702824069162943 -0.508764495647766 0.701535440095735 1 0.132663 0.153062 0.102291 0.165651 GeneID:150165,Genbank:XM_017028600.1,HGNC:HGNC:28778,MIM:611674 XK related 3 GO:0005886,GO:0016021 plasma membrane|integral component of membrane XKR4 38.5907311351096 30.1628958572929 47.0185664129264 1.55882136235796 0.640455607697794 0.168519047413743 1 0.312413 0.380044 0.700898 0.400536 GeneID:114786,Genbank:NM_052898.1,HGNC:HGNC:29394 XK related 4 GO:0016021 integral component of membrane XKR5 11.8751840004749 9.69556683466942 14.0548011662804 1.44961108576171 0.535665893410894 0.554493550947906 1 0.0362075 0.0441292 0.0741667 0.0692692 GeneID:389610,Genbank:NM_207411.4,HGNC:HGNC:20782 XK related 5 GO:0016021 integral component of membrane XKR6 90.3396903494323 90.5367138465635 90.1426668523011 0.99564765521609 -0.00629281043166818 0.993269697948896 1 0.369649 0.445135 0.464891 0.433882 GeneID:286046,Genbank:XM_024447129.1,HGNC:HGNC:27806 XK related 6 GO:0016021 integral component of membrane XKR8 260.590328870282 269.169593185012 252.011064555552 0.936253837491719 -0.0950283680247311 0.633471875632474 1 4.61167 5.26521 4.67771 4.48773 GeneID:55113,Genbank:NM_018053.3,HGNC:HGNC:25508 XK related 8 GO:0005886,GO:0016021,GO:0043652,GO:0070782 plasma membrane|integral component of membrane|engulfment of apoptotic cell|phosphatidylserine exposure on apoptotic cell surface XKR9 12.7378614391786 12.8761266198383 12.5995962585189 0.978523792947687 -0.0313211642700171 1 1 0.0701585 0.0684975 0.0603603 0.0633186 GeneID:389668,Genbank:XM_006716447.4,HGNC:HGNC:20937 XK related 9 GO:0016021 integral component of membrane XKRX 4.18187465099457 2.54640955915669 5.81733974283245 2.28452635276746 1.19189508460705 0.47232087283825 1 0.0139045 0.0194142 0.0463551 0.0185009 GeneID:402415,Genbank:XM_011530954.3,HGNC:HGNC:29845,MIM:300684 XK related, X-linked GO:0005886,GO:0016021 plasma membrane|integral component of membrane XPA 116.714142950596 118.085556559799 115.342729341392 0.976772542736692 -0.0339054484260535 0.94196032885638 1 1.28745 0.991666 1.21412 1.05987 GeneID:7507,Genbank:XM_006717278.1,HGNC:HGNC:12814,MIM:611153 XPA, DNA damage recognition and repair factor hsa01524,hsa03420 Platinum drug resistance|Nucleotide excision repair XPC 1003.23593184754 920.414256101404 1086.05760759367 1.17996608635103 0.238745395386871 0.119991998705237 1 6.69239 6.79144 8.32147 7.70751 GeneID:7508,Genbank:NM_001354729.1,HGNC:HGNC:12816,MIM:613208 XPC complex subunit, DNA damage recognition and repair factor hsa03420 Nucleotide excision repair XPNPEP1 1902.80592203777 1940.84027882083 1864.77156525471 0.960806299005535 -0.0576824855650282 0.671625793405212 1 16.0681 18.0068 16.2601 17.0334 GeneID:7511,Genbank:NM_001324128.1,HGNC:HGNC:12822,MIM:602443 X-prolyl aminopeptidase 1 GO:0004177,GO:0005737,GO:0005829,GO:0006508,GO:0010815,GO:0030145,GO:0042803,GO:0070006,GO:0070062 aminopeptidase activity|cytoplasm|cytosol|proteolysis|bradykinin catabolic process|manganese ion binding|protein homodimerization activity|metalloaminopeptidase activity|extracellular exosome XPNPEP3 286.676037260536 294.210243958667 279.141830562404 0.948783518909764 -0.0758491454942397 0.720554382684791 1 1.2611 1.20946 1.17529 1.20775 GeneID:63929,Genbank:NM_022098.3,HGNC:HGNC:28052,MIM:613553 X-prolyl aminopeptidase 3 GO:0051087 chaperone binding XPO1 3533.79604868097 3787.64737304477 3279.94472431717 0.865958311657858 -0.207630521450537 0.393746808126574 1 22.0998 20.0867 22.2541 15.4712 GeneID:7514,Genbank:XM_011533097.1,HGNC:HGNC:12825,MIM:602559 exportin 1 hsa03008,hsa03013,hsa05164,hsa05166 Ribosome biogenesis in eukaryotes|RNA transport|Influenza A|Human T-cell leukemia virus 1 infection XPO4 424.981036135067 438.432263955622 411.529808314513 0.938639425396319 -0.0913570361521205 0.781514184769507 1 1.25824 1.18141 1.45697 0.850113 GeneID:64328,Genbank:NM_022459.4,HGNC:HGNC:17796,MIM:611449 exportin 4 GO:0005049,GO:0005643,GO:0005654,GO:0005737,GO:0005829,GO:0008536,GO:0046827 nuclear export signal receptor activity|nuclear pore|nucleoplasm|cytoplasm|cytosol|Ran GTPase binding|positive regulation of protein export from nucleus XPO5 2604.16712740105 2746.30826952546 2462.02598527664 0.896485661350048 -0.157647586489317 0.256096420510684 1 17.9736 17.3752 17.4511 15.0035 GeneID:57510,Genbank:NM_020750.2,HGNC:HGNC:17675,MIM:607845 exportin 5 GO:0000049,GO:0003723,GO:0003729,GO:0005049,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006611,GO:0006886,GO:0008536,GO:0008565,GO:0010586,GO:0035068,GO:0035281,GO:0042272,GO:0042565,GO:0046825,GO:0070883,GO:0140142,GO:1900370 tRNA binding|RNA binding|mRNA binding|nuclear export signal receptor activity|nucleus|nucleoplasm|cytoplasm|cytosol|protein export from nucleus|intracellular protein transport|Ran GTPase binding|protein transporter activity|miRNA metabolic process|micro-ribonucleoprotein complex|pre-miRNA export from nucleus|nuclear RNA export factor complex|RNA nuclear export complex|regulation of protein export from nucleus|pre-miRNA binding|nucleocytoplasmic carrier activity|positive regulation of RNA interference hsa03013 RNA transport XPO6 2526.10717629555 2502.95959016588 2549.25476242521 1.01849617246767 0.0264405586324366 0.848946481283822 1 12.8667 12.6518 14.0458 12.6257 GeneID:23214,Genbank:XM_024450212.1,HGNC:HGNC:19733,MIM:608411 exportin 6 GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006611,GO:0006886,GO:0008536,GO:0008565 nucleus|nucleolus|cytoplasm|cytosol|plasma membrane|protein export from nucleus|intracellular protein transport|Ran GTPase binding|protein transporter activity XPO7 3420.07239068306 3440.89972987731 3399.2450514888 0.98789424811574 -0.0175714821105191 0.902678641586377 1 24.5245 23.9699 25.2038 23.1096 GeneID:23039,Genbank:NM_015024.4,HGNC:HGNC:14108,MIM:606140 exportin 7 GO:0005049,GO:0005634,GO:0005643,GO:0005737,GO:0006611,GO:0006886,GO:0008536,GO:0051028 nuclear export signal receptor activity|nucleus|nuclear pore|cytoplasm|protein export from nucleus|intracellular protein transport|Ran GTPase binding|mRNA transport XPOT 2993.66726013175 3295.55145425068 2691.78306601281 0.816792911104723 -0.291957749678556 0.0338618763632239 0.727962163534756 21.6633 21.0176 18.8917 15.8121 GeneID:11260,Genbank:NM_007235.5,HGNC:HGNC:12826,MIM:603180 exportin for tRNA GO:0000049,GO:0005654,GO:0005737,GO:0005829,GO:0006409,GO:0008536,GO:0016363,GO:0071528 tRNA binding|nucleoplasm|cytoplasm|cytosol|tRNA export from nucleus|Ran GTPase binding|nuclear matrix|tRNA re-export from nucleus hsa03013 RNA transport XPR1 909.566535787132 852.67854142681 966.454530147454 1.13343362497461 0.18069990786407 0.341851234444252 1 3.40278 3.29037 4.47611 3.21345 GeneID:9213,Genbank:NM_004736.3,HGNC:HGNC:12827,MIM:605237 xenotropic and polytropic retrovirus receptor 1 GO:0000822,GO:0001618,GO:0004872,GO:0004888,GO:0004930,GO:0005737,GO:0007186,GO:0009615,GO:0015114,GO:0015562,GO:0016021,GO:0030643,GO:0031226,GO:0035435 inositol hexakisphosphate binding|virus receptor activity|receptor activity|transmembrane signaling receptor activity|G-protein coupled receptor activity|cytoplasm|G-protein coupled receptor signaling pathway|response to virus|phosphate ion transmembrane transporter activity|efflux transmembrane transporter activity|integral component of membrane|cellular phosphate ion homeostasis|intrinsic component of plasma membrane|phosphate ion transmembrane transport XRCC1 1165.86419059831 1170.59654312477 1161.13183807185 0.991914630955887 -0.0117121343522044 0.923684388656227 1 14.5759 16.1183 15.3363 15.6595 GeneID:7515,Genbank:NM_006297.2,HGNC:HGNC:12828,MIM:194360 X-ray repair cross complementing 1 hsa03410 Base excision repair XRCC2 343.160063342588 330.570563252027 355.749563433148 1.07616830710339 0.105903725510572 0.567126908131289 1 3.73051 3.21644 4.32357 3.30518 GeneID:7516,Genbank:NM_005431.1,HGNC:HGNC:12829,MIM:600375 X-ray repair cross complementing 2 hsa03440 Homologous recombination XRCC3 801.987433027376 827.149853252907 776.825012801846 0.939158738585095 -0.0905590690483212 0.571184660834722 1 9.5838 11.7057 9.94003 11.1117 GeneID:7517,Genbank:XM_005268046.2,HGNC:HGNC:12830,MIM:600675 X-ray repair cross complementing 3 hsa03440 Homologous recombination XRCC4 123.90673257506 121.814022676718 125.999442473402 1.03435909679949 0.0487371307525888 0.864491143492498 1 1.05835 0.830142 0.909964 0.85487 GeneID:7518,Genbank:NM_001318012.1,HGNC:HGNC:12831,MIM:194363 X-ray repair cross complementing 4 hsa03450 Non-homologous end-joining XRCC5 8119.80334370238 8268.04769269827 7971.55899470649 0.964140422381257 -0.0526848115862026 0.700592365057246 1 89.1157 87.1834 86.1184 84.0119 GeneID:7520,Genbank:NM_021141.3,HGNC:HGNC:12833,MIM:194364 X-ray repair cross complementing 5 hsa03450 Non-homologous end-joining XRCC6 13188.2454113421 13418.1676030685 12958.3232196156 0.965729718315062 -0.0503086207408287 0.695383203104394 1 183.57 190.581 176.922 188.43 GeneID:2547,Genbank:NM_001469.4,HGNC:HGNC:4055,MIM:152690 X-ray repair cross complementing 6 hsa03450 Non-homologous end-joining XRN1 119.086778668775 113.578861392813 124.594695944738 1.0969884221134 0.13354829926186 0.829000864523428 1 0.416371 0.338634 0.56462 0.234214 GeneID:54464,Genbank:NM_019001.4,HGNC:HGNC:30654,MIM:607994 5'-3' exoribonuclease 1 GO:0000932,GO:0000956,GO:0002151,GO:0003723,GO:0004534,GO:0005634,GO:0005829,GO:0005886,GO:0016020,GO:0016075,GO:0017148,GO:0030425,GO:0032211,GO:0033574,GO:0043025,GO:0043488,GO:0045202,GO:0051880,GO:0070034,GO:0071028,GO:0071044,GO:0071409,GO:0090503,GO:1905795 P-body|nuclear-transcribed mRNA catabolic process|G-quadruplex RNA binding|RNA binding|5'-3' exoribonuclease activity|nucleus|cytosol|plasma membrane|membrane|rRNA catabolic process|negative regulation of translation|dendrite|negative regulation of telomere maintenance via telomerase|response to testosterone|neuronal cell body|regulation of mRNA stability|synapse|G-quadruplex DNA binding|telomerase RNA binding|nuclear mRNA surveillance|histone mRNA catabolic process|cellular response to cycloheximide|RNA phosphodiester bond hydrolysis, exonucleolytic|cellular response to puromycin hsa03008,hsa03018 Ribosome biogenesis in eukaryotes|RNA degradation XRN2 1923.36472793651 2088.9317927562 1757.79766311683 0.841481598016919 -0.248996372636974 0.0821616011064195 0.960511097314172 14.8619 13.7601 13.1839 11.5928 GeneID:22803,Genbank:NM_012255.4,HGNC:HGNC:12836,MIM:608851 5'-3' exoribonuclease 2 GO:0000175,GO:0000738,GO:0001147,GO:0003723,GO:0004518,GO:0004534,GO:0005634,GO:0005654,GO:0005730,GO:0006353,GO:0006355,GO:0006364,GO:0006396,GO:0006397,GO:0006401,GO:0007283,GO:0008409,GO:0016020,GO:0016070,GO:0016235,GO:0021766,GO:0030182,GO:0046872,GO:0060041 3'-5'-exoribonuclease activity|DNA catabolic process, exonucleolytic|transcription termination site sequence-specific DNA binding|RNA binding|nuclease activity|5'-3' exoribonuclease activity|nucleus|nucleoplasm|nucleolus|DNA-templated transcription, termination|regulation of transcription, DNA-templated|rRNA processing|RNA processing|mRNA processing|RNA catabolic process|spermatogenesis|5'-3' exonuclease activity|membrane|RNA metabolic process|aggresome|hippocampus development|neuron differentiation|metal ion binding|retina development in camera-type eye hsa03008,hsa03018 Ribosome biogenesis in eukaryotes|RNA degradation XRRA1 113.478955829379 114.040523830301 112.917387828456 0.990151430700933 -0.0142789114986636 0.964248985255933 1 0.432033 0.434928 0.387813 0.415205 GeneID:143570,Genbank:NM_001270381.1,HGNC:HGNC:18868,MIM:609788 X-ray radiation resistance associated 1 GO:0005634,GO:0005654,GO:0005737,GO:0010165,GO:0016604 nucleus|nucleoplasm|cytoplasm|response to X-ray|nuclear body XXYLT1 1133.38015461195 1172.96944789455 1093.79086132936 0.932497315503555 -0.100828522779844 0.496264106494565 1 3.81297 3.8549 3.62114 3.48744 GeneID:152002,Genbank:XM_011512448.3,HGNC:HGNC:26639,MIM:614552 xyloside xylosyltransferase 1 GO:0000287,GO:0016266,GO:0030145,GO:0030176,GO:0035252 magnesium ion binding|O-glycan processing|manganese ion binding|integral component of endoplasmic reticulum membrane|UDP-xylosyltransferase activity XYLB 76.9562384515019 75.8825980625276 78.0298788404762 1.02829740721554 0.0402575854081117 0.902428023746473 1 0.190339 0.154846 0.201023 0.167563 GeneID:9942,Genbank:NM_001349178.1,HGNC:HGNC:12839,MIM:604049 xylulokinase GO:0004856,GO:0005524,GO:0005997,GO:0042732 xylulokinase activity|ATP binding|xylulose metabolic process|D-xylose metabolic process hsa00040 Pentose and glucuronate interconversions XYLT1 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0.0040512 0 0 GeneID:64131,Genbank:NM_022166.3,HGNC:HGNC:15516,MIM:608124 xylosyltransferase 1 GO:0000139,GO:0005576,GO:0005789,GO:0006024,GO:0008375,GO:0015012,GO:0016021,GO:0030158,GO:0030203,GO:0030206 Golgi membrane|extracellular region|endoplasmic reticulum membrane|glycosaminoglycan biosynthetic process|acetylglucosaminyltransferase activity|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|protein xylosyltransferase activity|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process hsa00532,hsa00534 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin XYLT2 930.632647627915 808.680010456835 1052.58528479899 1.30160912992566 0.380296275708418 0.0141582716766837 0.492954085160359 7.50515 7.19026 9.70771 9.99463 GeneID:64132,Genbank:NM_022167.3,HGNC:HGNC:15517,MIM:608125 xylosyltransferase 2 GO:0000139,GO:0005789,GO:0006024,GO:0008375,GO:0015012,GO:0016021,GO:0030158,GO:0030203,GO:0030206,GO:0030210,GO:0050650 Golgi membrane|endoplasmic reticulum membrane|glycosaminoglycan biosynthetic process|acetylglucosaminyltransferase activity|heparan sulfate proteoglycan biosynthetic process|integral component of membrane|protein xylosyltransferase activity|glycosaminoglycan metabolic process|chondroitin sulfate biosynthetic process|heparin biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process hsa00532,hsa00534 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate|Glycosaminoglycan biosynthesis - heparan sulfate / heparin YAE1D1 250.120612682702 275.367016621079 224.874208744326 0.816634510202672 -0.292237559106995 0.167063101774087 1 3.25601 3.34057 2.80346 2.53824 GeneID:57002,Genbank:NM_001282446.1,HGNC:HGNC:24857 Yae1 domain containing 1 GO:0006413,GO:0042273 translational initiation|ribosomal large subunit biogenesis YAF2 145.004426921861 137.82268280704 152.186171036682 1.10421715741633 0.143023923129959 0.575978488190292 1 0.572498 0.557998 0.631068 0.538884 GeneID:10138,Genbank:NM_001190977.2,HGNC:HGNC:17363,MIM:607534 YY1 associated factor 2 GO:0003713,GO:0003714,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0045892,GO:0045893,GO:0046872,GO:0070317 transcription coactivator activity|transcription corepressor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of G0 to G1 transition YAP1 1608.55657704812 1490.67267618099 1726.44047791524 1.15816202007423 0.211837092020621 0.242899443189162 1 9.5886 9.03244 12.645 9.51992 GeneID:10413,Genbank:XM_005271378.3,HGNC:HGNC:16262,MIM:606608 Yes associated protein 1 hsa04390,hsa04392 Hippo signaling pathway|Hippo signaling pathway - multiple species YARS 4270.73688369198 4279.45651254504 4262.01725483892 0.995924889608062 -0.00589115327277148 0.957583011343499 1 40.328 42.1378 39.8449 44.3764 GeneID:8565,Genbank:XM_011542347.2,HGNC:HGNC:12840,MIM:603623 tyrosyl-tRNA synthetase GO:0000049,GO:0003723,GO:0004831,GO:0004871,GO:0005153,GO:0005524,GO:0005615,GO:0005737,GO:0005829,GO:0006418,GO:0006437,GO:0006915,GO:0016604,GO:0017101,GO:0017102 tRNA binding|RNA binding|tyrosine-tRNA ligase activity|signal transducer activity|interleukin-8 receptor binding|ATP binding|extracellular space|cytoplasm|cytosol|tRNA aminoacylation for protein translation|tyrosyl-tRNA aminoacylation|apoptotic process|nuclear body|aminoacyl-tRNA synthetase multienzyme complex|methionyl glutamyl tRNA synthetase complex hsa00970 Aminoacyl-tRNA biosynthesis YARS2 379.78722949531 398.516983334722 361.057475655898 0.906002732015662 -0.142412694219047 0.442279588096317 1 8.33658 8.81935 8.18289 7.29946 GeneID:51067,Genbank:NM_001040436.2,HGNC:HGNC:24249,MIM:610957 tyrosyl-tRNA synthetase 2 GO:0000049,GO:0003723,GO:0004831,GO:0005524,GO:0005739,GO:0005759,GO:0005829,GO:0006412,GO:0006418,GO:0016604,GO:0042803,GO:0043039,GO:0070184,GO:0072545 tRNA binding|RNA binding|tyrosine-tRNA ligase activity|ATP binding|mitochondrion|mitochondrial matrix|cytosol|translation|tRNA aminoacylation for protein translation|nuclear body|protein homodimerization activity|tRNA aminoacylation|mitochondrial tyrosyl-tRNA aminoacylation|tyrosine binding hsa00970 Aminoacyl-tRNA biosynthesis YBEY 342.296758205887 333.712905417619 350.880610994155 1.05144453600034 0.072372749501274 0.699335648811079 1 1.10637 1.05454 1.25393 1.02599 GeneID:54059,Genbank:XM_017028394.1,HGNC:HGNC:1299,MIM:617461 ybeY metallopeptidase (putative) GO:0004222,GO:0004519,GO:0005634,GO:0005739,GO:0006364,GO:0046872 metalloendopeptidase activity|endonuclease activity|nucleus|mitochondrion|rRNA processing|metal ion binding YBX1 31662.8896489315 32290.2391554359 31035.5401424271 0.961143087018679 -0.0571768714162894 0.653539724127664 1 417.508 424.202 404.452 412.697 GeneID:4904,Genbank:NM_004559.4,HGNC:HGNC:8014,MIM:154030 Y-box binding protein 1 GO:0003697,GO:0003723,GO:0005576,GO:0006351,GO:0006355,GO:0006397,GO:0008380,GO:0010494,GO:0030529,GO:0051781,GO:0070934,GO:0071204 single-stranded DNA binding|RNA binding|extracellular region|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA processing|RNA splicing|cytoplasmic stress granule|intracellular ribonucleoprotein complex|positive regulation of cell division|CRD-mediated mRNA stabilization|histone pre-mRNA 3'end processing complex YBX2 2.19357516596095 2.45035700978681 1.93679332213509 0.790412709005044 -0.339321950759376 0.969984043021147 1 0 0.11118 0 0.0891272 GeneID:51087,Genbank:NM_015982.3,HGNC:HGNC:17948,MIM:611447 Y-box binding protein 2 GO:0001650,GO:0003677,GO:0003723,GO:0005634,GO:0005737,GO:0006355,GO:0006366,GO:0007283,GO:0009386,GO:0048599 fibrillar center|DNA binding|RNA binding|nucleus|cytoplasm|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|spermatogenesis|translational attenuation|oocyte development YBX3 4156.81812425262 4233.56533955214 4080.07090895311 0.963743460112685 -0.053278929841542 0.674836982880713 1 52.997 56.7441 54.6492 52.6479 GeneID:8531,Genbank:NM_001145426.1,HGNC:HGNC:2428,MIM:603437 Y-box binding protein 3 GO:0000122,GO:0000977,GO:0001227,GO:0001701,GO:0003690,GO:0003697,GO:0003700,GO:0003714,GO:0003723,GO:0003730,GO:0005634,GO:0005737,GO:0005829,GO:0005844,GO:0005923,GO:0006351,GO:0007283,GO:0008584,GO:0009409,GO:0009566,GO:0017048,GO:0046622,GO:0048471,GO:0048642,GO:0060546,GO:0070935,GO:0071356,GO:0071474,GO:1902219,GO:2000767 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|in utero embryonic development|double-stranded DNA binding|single-stranded DNA binding|DNA binding transcription factor activity|transcription corepressor activity|RNA binding|mRNA 3'-UTR binding|nucleus|cytoplasm|cytosol|polysome|bicellular tight junction|transcription, DNA-templated|spermatogenesis|male gonad development|response to cold|fertilization|Rho GTPase binding|positive regulation of organ growth|perinuclear region of cytoplasm|negative regulation of skeletal muscle tissue development|negative regulation of necroptotic process|3'-UTR-mediated mRNA stabilization|cellular response to tumor necrosis factor|cellular hyperosmotic response|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|positive regulation of cytoplasmic translation hsa04530 Tight junction YDJC 537.379117797367 540.721899794909 534.036335799824 0.987635854960524 -0.0179488821057669 0.903984230077209 1 16.9083 17.4953 16.5137 17.4871 GeneID:150223,Genbank:XM_011529906.2,HGNC:HGNC:27158 YdjC chitooligosaccharide deacetylase homolog GO:0000287,GO:0005975,GO:0016787 magnesium ion binding|carbohydrate metabolic process|hydrolase activity YEATS2 2015.25461473023 1996.81122884588 2033.69800061458 1.01847283871196 0.026407506098527 0.851507846662373 1 8.08032 7.9059 9.44826 7.17534 GeneID:55689,Genbank:XM_011512965.1,HGNC:HGNC:25489,MIM:613373 YEATS domain containing 2 GO:0000122,GO:0005671,GO:0017025,GO:0042393,GO:0043966,GO:0045892,GO:0072686,GO:0140030 negative regulation of transcription from RNA polymerase II promoter|Ada2/Gcn5/Ada3 transcription activator complex|TBP-class protein binding|histone binding|histone H3 acetylation|negative regulation of transcription, DNA-templated|mitotic spindle|modification-dependent protein binding YEATS4 450.442000416259 488.467573229958 412.416427602561 0.84430666477098 -0.24416099241565 0.167926102314873 1 13.1065 15.3303 12.1822 11.6766 GeneID:8089,Genbank:NM_006530.3,HGNC:HGNC:24859,MIM:602116 YEATS domain containing 4 GO:0000278,GO:0003677,GO:0003700,GO:0005200,GO:0005654,GO:0006351,GO:0008022,GO:0016363,GO:0031965,GO:0035267,GO:0040008,GO:0043967,GO:0043968,GO:0045893,GO:0045944 mitotic cell cycle|DNA binding|DNA binding transcription factor activity|structural constituent of cytoskeleton|nucleoplasm|transcription, DNA-templated|protein C-terminus binding|nuclear matrix|nuclear membrane|NuA4 histone acetyltransferase complex|regulation of growth|histone H4 acetylation|histone H2A acetylation|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter YES1 903.841463051097 957.512552823544 850.170373278649 0.8878947547702 -0.171539415800294 0.558358174120935 1 7.56565 6.38718 7.59742 5.03257 GeneID:7525,Genbank:XM_024451244.1,HGNC:HGNC:12841,MIM:164880 YES proto-oncogene 1, Src family tyrosine kinase GO:0001784,GO:0004713,GO:0004715,GO:0005102,GO:0005154,GO:0005524,GO:0005794,GO:0005815,GO:0005829,GO:0005884,GO:0005886,GO:0005925,GO:0006464,GO:0007169,GO:0015758,GO:0016477,GO:0019899,GO:0030154,GO:0031234,GO:0031295,GO:0036120,GO:0038083,GO:0038096,GO:0042127,GO:0043114,GO:0044325,GO:0045087,GO:0045944,GO:0048013,GO:0050731,GO:0050900,GO:0070062,GO:0071300,GO:0071560 phosphotyrosine residue binding|protein tyrosine kinase activity|non-membrane spanning protein tyrosine kinase activity|receptor binding|epidermal growth factor receptor binding|ATP binding|Golgi apparatus|microtubule organizing center|cytosol|actin filament|plasma membrane|focal adhesion|cellular protein modification process|transmembrane receptor protein tyrosine kinase signaling pathway|glucose transport|cell migration|enzyme binding|cell differentiation|extrinsic component of cytoplasmic side of plasma membrane|T cell costimulation|cellular response to platelet-derived growth factor stimulus|peptidyl-tyrosine autophosphorylation|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of cell proliferation|regulation of vascular permeability|ion channel binding|innate immune response|positive regulation of transcription from RNA polymerase II promoter|ephrin receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|leukocyte migration|extracellular exosome|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus hsa04520 Adherens junction YIF1A 954.659065305454 963.858123087085 945.460007523822 0.980912008601082 -0.0278043676664914 0.84110191577923 1 37.2968 43.1697 39.3072 42.7409 GeneID:10897,Genbank:NM_001300861.1,HGNC:HGNC:16688,MIM:611484 Yip1 interacting factor homolog A, membrane trafficking protein GO:0005789,GO:0005793,GO:0006888,GO:0015031,GO:0030134,GO:0030173,GO:0036498 endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|ER to Golgi vesicle-mediated transport|protein transport|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane|IRE1-mediated unfolded protein response YIF1B 1343.54494834565 1314.17460424061 1372.91529245069 1.04469778066061 0.0630856471840785 0.674542977928872 1 14.776 14.9401 16.189 15.8308 GeneID:90522,Genbank:NM_001039673.2,HGNC:HGNC:30511 Yip1 interacting factor homolog B, membrane trafficking protein GO:0005789,GO:0005793,GO:0006888,GO:0030134,GO:0030173 endoplasmic reticulum membrane|endoplasmic reticulum-Golgi intermediate compartment|ER to Golgi vesicle-mediated transport|COPII-coated ER to Golgi transport vesicle|integral component of Golgi membrane YIPF1 629.952100747717 602.296374651304 657.60782684413 1.09183427714445 0.126753895007068 0.450144150262093 1 9.65037 11.2003 11.5491 12.5152 GeneID:54432,Genbank:NM_018982.4,HGNC:HGNC:25231,MIM:617521 Yip1 domain family member 1 GO:0000138,GO:0005794,GO:0005797,GO:0005802,GO:0016021,GO:0017137,GO:0030133,GO:0031902 Golgi trans cisterna|Golgi apparatus|Golgi medial cisterna|trans-Golgi network|integral component of membrane|Rab GTPase binding|transport vesicle|late endosome membrane YIPF2 1786.22989127224 1588.47625116436 1983.98353138011 1.2489853278737 0.320756529365261 0.0257959033953183 0.639546731856683 20.4166 22.2077 26.4202 29.0991 GeneID:78992,Genbank:XM_024451699.1,HGNC:HGNC:28476,MIM:617522 Yip1 domain family member 2 GO:0000138,GO:0005794,GO:0005797,GO:0005802,GO:0016021,GO:0017137,GO:0030133,GO:0031902 Golgi trans cisterna|Golgi apparatus|Golgi medial cisterna|trans-Golgi network|integral component of membrane|Rab GTPase binding|transport vesicle|late endosome membrane YIPF3 3339.40761194635 3118.89375417944 3559.92146971326 1.14140517449266 0.190811008514229 0.165780992582787 1 77.2964 83.7119 91.6288 96.4844 GeneID:25844,Genbank:NM_015388.3,HGNC:HGNC:21023,MIM:609775 Yip1 domain family member 3 GO:0005794,GO:0005886,GO:0016021,GO:0030133,GO:0030154,GO:0043231 Golgi apparatus|plasma membrane|integral component of membrane|transport vesicle|cell differentiation|intracellular membrane-bounded organelle YIPF4 416.029904799425 411.383301299452 420.676508299397 1.02259014153124 0.032228022637059 0.86689441656649 1 8.86895 9.67384 10.1194 8.55304 GeneID:84272,Genbank:NM_032312.3,HGNC:HGNC:28145,MIM:617534 Yip1 domain family member 4 GO:0005783,GO:0005794,GO:0005886,GO:0016021,GO:0043231 endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of membrane|intracellular membrane-bounded organelle YIPF5 1589.35873133354 1544.48346084608 1634.23400182101 1.05811039305385 0.0814901522185094 0.563377605273909 1 19.5823 18.4876 22.1015 18.6156 GeneID:81555,Genbank:NM_030799.8,HGNC:HGNC:24877,MIM:611483 Yip1 domain family member 5 GO:0005654,GO:0005783,GO:0005789,GO:0005794,GO:0015031,GO:0016021,GO:0016192,GO:0030134,GO:0043231,GO:0060628,GO:0070971 nucleoplasm|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|protein transport|integral component of membrane|vesicle-mediated transport|COPII-coated ER to Golgi transport vesicle|intracellular membrane-bounded organelle|regulation of ER to Golgi vesicle-mediated transport|endoplasmic reticulum exit site YIPF6 1829.29013489646 1838.63383587324 1819.94643391967 0.989836256905012 -0.0147382069569934 0.965452213115952 1 10.7975 9.2271 11.238 8.70039 GeneID:286451,Genbank:XM_017029451.2,HGNC:HGNC:28304,MIM:300996 Yip1 domain family member 6 GO:0000138,GO:0000139,GO:0005783,GO:0005797,GO:0005801,GO:0005802,GO:0016021,GO:0030134,GO:0042802,GO:0060576 Golgi trans cisterna|Golgi membrane|endoplasmic reticulum|Golgi medial cisterna|cis-Golgi network|trans-Golgi network|integral component of membrane|COPII-coated ER to Golgi transport vesicle|identical protein binding|intestinal epithelial cell development YIPF7 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:285525,Genbank:XM_011513679.2,HGNC:HGNC:26825 Yip1 domain family member 7 GO:0005789,GO:0005794,GO:0016021 endoplasmic reticulum membrane|Golgi apparatus|integral component of membrane YJEFN3 32.6401422171825 23.10979113115 42.1704933032149 1.82478902833408 0.867729677488471 0.0823876304178332 0.961749481612257 0.275463 0.235027 0.557898 0.300062 GeneID:374887,Genbank:NM_198537.3,HGNC:HGNC:24785 YjeF N-terminal domain containing 3 YJU2 698.005431257744 718.518715153498 677.492147361991 0.942901184163669 -0.084821510187375 0.585169859493861 1 15.7904 17.2466 15.6106 15.5081 GeneID:55702,Genbank:NM_018074.5,HGNC:HGNC:25518 YJU2 splicing factor homolog YKT6 6014.62119927731 5726.24937861821 6302.99301993641 1.10071926721735 0.138446563873175 0.307086287907242 1 70.3799 77.4914 83.4389 81.9216 GeneID:10652,Genbank:XM_005249582.4,HGNC:HGNC:16959,MIM:606209 YKT6 v-SNARE homolog GO:0000139,GO:0000149,GO:0005484,GO:0005737,GO:0005739,GO:0005768,GO:0005783,GO:0005794,GO:0005829,GO:0005887,GO:0006888,GO:0006903,GO:0006904,GO:0006906,GO:0015031,GO:0019706,GO:0030133,GO:0030659,GO:0031201,GO:0033116,GO:0042147,GO:0043025,GO:0045296,GO:0070062,GO:0097440,GO:0097441 Golgi membrane|SNARE binding|SNAP receptor activity|cytoplasm|mitochondrion|endosome|endoplasmic reticulum|Golgi apparatus|cytosol|integral component of plasma membrane|ER to Golgi vesicle-mediated transport|vesicle targeting|vesicle docking involved in exocytosis|vesicle fusion|protein transport|protein-cysteine S-palmitoyltransferase activity|transport vesicle|cytoplasmic vesicle membrane|SNARE complex|endoplasmic reticulum-Golgi intermediate compartment membrane|retrograde transport, endosome to Golgi|neuronal cell body|cadherin binding|extracellular exosome|apical dendrite|basal dendrite hsa04130 SNARE interactions in vesicular transport YLPM1 1584.312431141 1627.8994263816 1540.72543590041 0.946450014621019 -0.079401780783663 0.59427454756682 1 5.38768 5.03364 5.42355 4.5258 GeneID:56252,Genbank:XM_011536967.2,HGNC:HGNC:17798 YLP motif containing 1 GO:0003723,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0016607 RNA binding|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck YME1L1 2393.64441009727 2509.34606769813 2277.94275249641 0.907783418883317 -0.139579957915013 0.413287621262877 1 18.6956 16.7607 18.0614 14.4429 GeneID:10730,Genbank:NM_001253866.1,HGNC:HGNC:12843,MIM:607472 YME1 like 1 ATPase GO:0004176,GO:0004222,GO:0005524,GO:0005739,GO:0005743,GO:0006515,GO:0006851,GO:0007005,GO:0008237,GO:0008283,GO:0016020,GO:0016021,GO:0016604,GO:0034214,GO:0034982,GO:0035694,GO:0043066,GO:0046872 ATP-dependent peptidase activity|metalloendopeptidase activity|ATP binding|mitochondrion|mitochondrial inner membrane|protein quality control for misfolded or incompletely synthesized proteins|mitochondrial calcium ion transmembrane transport|mitochondrion organization|metallopeptidase activity|cell proliferation|membrane|integral component of membrane|nuclear body|protein hexamerization|mitochondrial protein processing|mitochondrial protein catabolic process|negative regulation of apoptotic process|metal ion binding YOD1 177.202757857375 199.301105114065 155.104410600686 0.778241598369041 -0.361709997952621 0.24948408191353 1 1.58346 1.2557 1.31991 0.883335 GeneID:55432,Genbank:NM_001276320.1,HGNC:HGNC:25035,MIM:612023 YOD1 deubiquitinase GO:0003676,GO:0004843,GO:0005634,GO:0005737,GO:0005829,GO:0016236,GO:0016579,GO:0030433,GO:0030968,GO:0031625,GO:0035523,GO:0035871,GO:0046872,GO:0061578,GO:0070536,GO:0071108,GO:1904265,GO:1990167,GO:1990168,GO:1990380 nucleic acid binding|thiol-dependent ubiquitin-specific protease activity|nucleus|cytoplasm|cytosol|macroautophagy|protein deubiquitination|ubiquitin-dependent ERAD pathway|endoplasmic reticulum unfolded protein response|ubiquitin protein ligase binding|protein K29-linked deubiquitination|protein K11-linked deubiquitination|metal ion binding|Lys63-specific deubiquitinase activity|protein K63-linked deubiquitination|protein K48-linked deubiquitination|ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol|protein K27-linked deubiquitination|protein K33-linked deubiquitination|Lys48-specific deubiquitinase activity hsa04141 Protein processing in endoplasmic reticulum YPEL1 96.8131773505339 79.2650716015442 114.361283099524 1.44277019863685 0.528841528735162 0.0775635035722121 0.94157495521624 0.743897 0.664834 1.0464 1.23881 GeneID:29799,Genbank:NM_013313.4,HGNC:HGNC:12845,MIM:608082 yippee like 1 GO:0005634,GO:0046872 nucleus|metal ion binding YPEL2 50.6827460387985 54.8389537436849 46.5265383339121 0.848421334793791 -0.237147194888533 0.567322272794009 1 0.406412 0.454973 0.413365 0.306951 GeneID:388403,Genbank:NM_001005404.3,HGNC:HGNC:18326,MIM:609723 yippee like 2 GO:0005730,GO:0046872 nucleolus|metal ion binding YPEL3 149.392419622037 128.694639614337 170.090199629738 1.32165722006334 0.402348053518452 0.17481036935417 1 2.63045 3.42935 3.51698 3.66878 GeneID:83719,Genbank:NM_031477.4,HGNC:HGNC:18327,MIM:609724 yippee like 3 GO:0005730,GO:0046872,GO:2000774 nucleolus|metal ion binding|positive regulation of cellular senescence YPEL4 5.8588637279706 3.47852608838648 8.23920136755471 2.36858978722695 1.24402836186308 0.357140723130076 1 0.021274 0.114722 0.13907 0.074271 GeneID:219539,Genbank:NM_145008.2,HGNC:HGNC:18328,MIM:609725 yippee like 4 GO:0005730,GO:0046872 nucleolus|metal ion binding YPEL5 562.15152696519 570.39370724939 553.90934668099 0.971100030805227 -0.0423081828539601 0.820376554350178 1 7.47829 7.09736 7.0909 7.38837 GeneID:51646,Genbank:XM_017004318.1,HGNC:HGNC:18329,MIM:609726 yippee like 5 GO:0046872 metal ion binding YRDC 992.195490632449 1112.6152472155 871.775734049402 0.783537468348709 -0.351925829623582 0.0203621482611753 0.585494015351855 30.4591 32.5501 23.1572 26.9196 GeneID:79693,Genbank:NM_024640.3,HGNC:HGNC:28905,MIM:612276 yrdC N6-threonylcarbamoyltransferase domain containing GO:0000049,GO:0002949,GO:0003725,GO:0005737,GO:0005739,GO:0006450,GO:0016020,GO:0016779,GO:0051051 tRNA binding|tRNA threonylcarbamoyladenosine modification|double-stranded RNA binding|cytoplasm|mitochondrion|regulation of translational fidelity|membrane|nucleotidyltransferase activity|negative regulation of transport YTHDC1 1049.31232773075 1115.70651210384 982.918143357655 0.880982707095803 -0.18281439427968 0.374967467726208 1 5.30062 4.83292 5.13652 4.13724 GeneID:91746,Genbank:NM_133370.3,HGNC:HGNC:30626,MIM:617283 YTH domain containing 1 GO:0003723,GO:0005634,GO:0005654,GO:0005886,GO:0006376,GO:0016607,GO:0048024,GO:1990247 RNA binding|nucleus|nucleoplasm|plasma membrane|mRNA splice site selection|nuclear speck|regulation of mRNA splicing, via spliceosome|N6-methyladenosine-containing RNA binding YTHDC2 413.152112652781 419.146991490761 407.157233814801 0.97139486166102 -0.0418702398575898 0.891706314446058 1 2.02917 2.07432 2.51995 1.65587 GeneID:64848,Genbank:NM_022828.4,HGNC:HGNC:24721,MIM:616530 YTH domain containing 2 GO:0003723,GO:0004004,GO:0005524,GO:0005783,GO:0006396,GO:0008186,GO:0034612,GO:0044829,GO:0070063,GO:0070555,GO:1990247 RNA binding|ATP-dependent RNA helicase activity|ATP binding|endoplasmic reticulum|RNA processing|RNA-dependent ATPase activity|response to tumor necrosis factor|positive regulation by host of viral genome replication|RNA polymerase binding|response to interleukin-1|N6-methyladenosine-containing RNA binding YTHDF1 1536.04983593469 1489.29073987109 1582.80893199829 1.06279377802033 0.0878616869065317 0.554983839441924 1 18.3859 19.3868 20.8657 19.5025 GeneID:54915,Genbank:NM_017798.3,HGNC:HGNC:15867,MIM:616529 YTH N6-methyladenosine RNA binding protein 1 GO:0003723,GO:0005737,GO:0043022,GO:0045727,GO:0045948,GO:1990247 RNA binding|cytoplasm|ribosome binding|positive regulation of translation|positive regulation of translational initiation|N6-methyladenosine-containing RNA binding YTHDF2 2215.51721059565 2307.84759660537 2123.18682458593 0.919985716435063 -0.120316632618004 0.388428086091519 1 31.1602 31.8664 30.4406 28.1056 GeneID:51441,Genbank:NM_001173128.1,HGNC:HGNC:31675,MIM:610640 YTH N6-methyladenosine RNA binding protein 2 GO:0000932,GO:0001556,GO:0003723,GO:0005634,GO:0005815,GO:0005829,GO:0006959,GO:0036464,GO:0043488,GO:0045746,GO:0048598,GO:0061157,GO:0098508,GO:1902036,GO:1903538,GO:1903679,GO:1990247 P-body|oocyte maturation|RNA binding|nucleus|microtubule organizing center|cytosol|humoral immune response|cytoplasmic ribonucleoprotein granule|regulation of mRNA stability|negative regulation of Notch signaling pathway|embryonic morphogenesis|mRNA destabilization|endothelial to hematopoietic transition|regulation of hematopoietic stem cell differentiation|regulation of meiotic cell cycle process involved in oocyte maturation|positive regulation of cap-independent translational initiation|N6-methyladenosine-containing RNA binding YTHDF3 793.188179239918 857.877221749601 728.499136730236 0.849188110210567 -0.235843923196988 0.279356244165419 1 6.87211 6.35837 6.68258 4.72283 GeneID:253943,Genbank:NM_001277813.1,HGNC:HGNC:26465 YTH N6-methyladenosine RNA binding protein 3 GO:0003723,GO:0005829,GO:0043022,GO:0045727,GO:0045948,GO:0061157,GO:1990247 RNA binding|cytosol|ribosome binding|positive regulation of translation|positive regulation of translational initiation|mRNA destabilization|N6-methyladenosine-containing RNA binding YWHAB 6105.9101476606 6023.45178391328 6188.36851140792 1.02737910643447 0.0389686393485256 0.76716108580607 1 63.7733 66.3122 71.1189 63.7997 GeneID:7529,Genbank:NM_003404.4,HGNC:HGNC:12849,MIM:601289 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta GO:0000165,GO:0003714,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005925,GO:0006605,GO:0008022,GO:0016020,GO:0016032,GO:0017053,GO:0019899,GO:0019904,GO:0030659,GO:0032403,GO:0035308,GO:0035329,GO:0042470,GO:0042802,GO:0042826,GO:0043085,GO:0043234,GO:0043488,GO:0045296,GO:0045744,GO:0045892,GO:0048471,GO:0050815,GO:0051219,GO:0051220,GO:0051291,GO:0061024,GO:0070062,GO:1900740 MAPK cascade|transcription corepressor activity|nucleus|cytoplasm|mitochondrion|cytosol|focal adhesion|protein targeting|protein C-terminus binding|membrane|viral process|transcriptional repressor complex|enzyme binding|protein domain specific binding|cytoplasmic vesicle membrane|protein complex binding|negative regulation of protein dephosphorylation|hippo signaling|melanosome|identical protein binding|histone deacetylase binding|positive regulation of catalytic activity|protein complex|regulation of mRNA stability|cadherin binding|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of transcription, DNA-templated|perinuclear region of cytoplasm|phosphoserine residue binding|phosphoprotein binding|cytoplasmic sequestering of protein|protein heterooligomerization|membrane organization|extracellular exosome|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway hsa04110,hsa04114,hsa04151,hsa04390,hsa05161,hsa05203 Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Hepatitis B|Viral carcinogenesis YWHAE 18366.5533845881 18837.6921529929 17895.4146161833 0.949979141332345 -0.0740322583140458 0.561868258337739 1 269.321 279.492 263.979 266.419 GeneID:7531,Genbank:XM_017025005.2,HGNC:HGNC:12851,MIM:605066 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon GO:0000086,GO:0000165,GO:0001764,GO:0003064,GO:0003723,GO:0005246,GO:0005634,GO:0005737,GO:0005739,GO:0005829,GO:0005871,GO:0005925,GO:0006605,GO:0010389,GO:0015459,GO:0016020,GO:0016032,GO:0017112,GO:0019899,GO:0019904,GO:0021762,GO:0021766,GO:0021987,GO:0023026,GO:0030424,GO:0030659,GO:0031625,GO:0034605,GO:0035329,GO:0035556,GO:0042470,GO:0042802,GO:0042826,GO:0043154,GO:0044325,GO:0045296,GO:0046827,GO:0046982,GO:0050815,GO:0051219,GO:0051480,GO:0060306,GO:0061024,GO:0070062,GO:0086013,GO:0086091,GO:0090724,GO:0097110,GO:0097711,GO:1900034,GO:1900740,GO:1901016,GO:1901020,GO:1902309,GO:1905913 G2/M transition of mitotic cell cycle|MAPK cascade|neuron migration|regulation of heart rate by hormone|RNA binding|calcium channel regulator activity|nucleus|cytoplasm|mitochondrion|cytosol|kinesin complex|focal adhesion|protein targeting|regulation of G2/M transition of mitotic cell cycle|potassium channel regulator activity|membrane|viral process|Rab guanyl-nucleotide exchange factor activity|enzyme binding|protein domain specific binding|substantia nigra development|hippocampus development|cerebral cortex development|MHC class II protein complex binding|axon|cytoplasmic vesicle membrane|ubiquitin protein ligase binding|cellular response to heat|hippo signaling|intracellular signal transduction|melanosome|identical protein binding|histone deacetylase binding|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|ion channel binding|cadherin binding|positive regulation of protein export from nucleus|protein heterodimerization activity|phosphoserine residue binding|phosphoprotein binding|regulation of cytosolic calcium ion concentration|regulation of membrane repolarization|membrane organization|extracellular exosome|membrane repolarization during cardiac muscle cell action potential|regulation of heart rate by cardiac conduction|central region of growth cone|scaffold protein binding|ciliary basal body-plasma membrane docking|regulation of cellular response to heat|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of potassium ion transmembrane transporter activity|negative regulation of calcium ion transmembrane transporter activity|negative regulation of peptidyl-serine dephosphorylation|negative regulation of calcium ion export across plasma membrane hsa04110,hsa04114,hsa04151,hsa04390,hsa04722,hsa05203 Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Neurotrophin signaling pathway|Viral carcinogenesis YWHAG 10825.3963714082 10516.3771526044 11134.4155902119 1.05876913966084 0.0823880497881128 0.518077143074112 1 127.049 122.58 144.859 123.479 GeneID:7532,Genbank:NM_012479.3,HGNC:HGNC:12852,MIM:605356 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma GO:0003723,GO:0003779,GO:0005080,GO:0005159,GO:0005737,GO:0005925,GO:0006605,GO:0007165,GO:0016020,GO:0019904,GO:0030234,GO:0030971,GO:0031982,GO:0032869,GO:0042802,GO:0043209,GO:0045664,GO:0048167,GO:0070062 RNA binding|actin binding|protein kinase C binding|insulin-like growth factor receptor binding|cytoplasm|focal adhesion|protein targeting|signal transduction|membrane|protein domain specific binding|enzyme regulator activity|receptor tyrosine kinase binding|vesicle|cellular response to insulin stimulus|identical protein binding|myelin sheath|regulation of neuron differentiation|regulation of synaptic plasticity|extracellular exosome hsa04110,hsa04114,hsa04151,hsa04390,hsa05203 Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Viral carcinogenesis YWHAH 3673.46180059316 3717.96931742429 3628.95428376204 0.976058158079712 -0.0349609820649459 0.790244944804127 1 94.5689 97.817 98.5803 91.2683 GeneID:7533,Genbank:NM_003405.3,HGNC:HGNC:12853,MIM:113508 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta GO:0002028,GO:0003779,GO:0005159,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006713,GO:0006886,GO:0014704,GO:0017080,GO:0019899,GO:0019904,GO:0021762,GO:0030659,GO:0035259,GO:0042802,GO:0042921,GO:0044325,GO:0045664,GO:0045893,GO:0046982,GO:0048167,GO:0050774,GO:0061024,GO:0070062,GO:0086010,GO:1900740,GO:2000649 regulation of sodium ion transport|actin binding|insulin-like growth factor receptor binding|cytoplasm|mitochondrion|cytosol|plasma membrane|glucocorticoid catabolic process|intracellular protein transport|intercalated disc|sodium channel regulator activity|enzyme binding|protein domain specific binding|substantia nigra development|cytoplasmic vesicle membrane|glucocorticoid receptor binding|identical protein binding|glucocorticoid receptor signaling pathway|ion channel binding|regulation of neuron differentiation|positive regulation of transcription, DNA-templated|protein heterodimerization activity|regulation of synaptic plasticity|negative regulation of dendrite morphogenesis|membrane organization|extracellular exosome|membrane depolarization during action potential|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|regulation of sodium ion transmembrane transporter activity hsa04110,hsa04114,hsa04151,hsa04390,hsa05203 Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Viral carcinogenesis YWHAQ 13076.9332416924 12827.3572827203 13326.5092006645 1.03891307515201 0.0550749503987365 0.662789123353045 1 250.194 248.378 261.347 261.367 GeneID:10971,Genbank:NM_006826.3,HGNC:HGNC:12854,MIM:609009 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta GO:0005737,GO:0005739,GO:0005829,GO:0005925,GO:0006605,GO:0007264,GO:0008022,GO:0016020,GO:0019904,GO:0021762,GO:0030659,GO:0034766,GO:0042802,GO:0043234,GO:0044325,GO:0045892,GO:0047485,GO:0061024,GO:0070062,GO:0071889,GO:1900740 cytoplasm|mitochondrion|cytosol|focal adhesion|protein targeting|small GTPase mediated signal transduction|protein C-terminus binding|membrane|protein domain specific binding|substantia nigra development|cytoplasmic vesicle membrane|negative regulation of ion transmembrane transport|identical protein binding|protein complex|ion channel binding|negative regulation of transcription, DNA-templated|protein N-terminus binding|membrane organization|extracellular exosome|14-3-3 protein binding|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway hsa04110,hsa04114,hsa04151,hsa04390,hsa05130,hsa05161,hsa05203 Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Pathogenic Escherichia coli infection|Hepatitis B|Viral carcinogenesis YWHAZ 16625.7227948789 17339.9558407238 15911.4897490339 0.9176199694618 -0.124031306922876 0.349609106779197 1 164.464 153.089 152.591 142.118 GeneID:7534,Genbank:NM_003406.3,HGNC:HGNC:12855,MIM:601288 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta GO:0005634,GO:0005739,GO:0006605,GO:0008134,GO:0010941,GO:0019901,GO:0019904,GO:0031625,GO:0042470,GO:0042802,GO:0044325,GO:0045296,GO:0051683,GO:0090168 nucleus|mitochondrion|protein targeting|transcription factor binding|regulation of cell death|protein kinase binding|protein domain specific binding|ubiquitin protein ligase binding|melanosome|identical protein binding|ion channel binding|cadherin binding|establishment of Golgi localization|Golgi reassembly hsa04110,hsa04114,hsa04151,hsa04390,hsa05130,hsa05161,hsa05203 Cell cycle|Oocyte meiosis|PI3K-Akt signaling pathway|Hippo signaling pathway|Pathogenic Escherichia coli infection|Hepatitis B|Viral carcinogenesis YY1 1691.03150388362 1730.88206437754 1651.18094338969 0.95395346532953 -0.0680092028449925 0.622741431747 1 21.047 22.6689 22.5689 19.9851 GeneID:7528,Genbank:NM_003403.4,HGNC:HGNC:12856,MIM:600013 YY1 transcription factor GO:0000122,GO:0000400,GO:0000724,GO:0000978,GO:0000987,GO:0001078,GO:0001158,GO:0003677,GO:0003700,GO:0003713,GO:0003714,GO:0003723,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006351,GO:0006357,GO:0006403,GO:0006974,GO:0007283,GO:0008270,GO:0009952,GO:0010225,GO:0010629,GO:0016363,GO:0016579,GO:0030154,GO:0031011,GO:0031519,GO:0032688,GO:0034644,GO:0034696,GO:0042826,GO:0044212,GO:0045944,GO:0046332,GO:0048593,GO:0051276,GO:0071347,GO:1902894 negative regulation of transcription from RNA polymerase II promoter|four-way junction DNA binding|double-strand break repair via homologous recombination|RNA polymerase II proximal promoter sequence-specific DNA binding|proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|enhancer sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|RNA binding|nucleus|nucleoplasm|transcription factor complex|cytoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|RNA localization|cellular response to DNA damage stimulus|spermatogenesis|zinc ion binding|anterior/posterior pattern specification|response to UV-C|negative regulation of gene expression|nuclear matrix|protein deubiquitination|cell differentiation|Ino80 complex|PcG protein complex|negative regulation of interferon-beta production|cellular response to UV|response to prostaglandin F|histone deacetylase binding|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|SMAD binding|camera-type eye morphogenesis|chromosome organization|cellular response to interleukin-1|negative regulation of pri-miRNA transcription from RNA polymerase II promoter YY1AP1 1294.3721246243 1234.70660188436 1354.03764736425 1.09664728875489 0.133099590840379 0.360270742486831 1 9.35354 8.74171 10.3773 9.91166 GeneID:55249,Genbank:NM_139118.2,HGNC:HGNC:30935,MIM:607860 YY1 associated protein 1 GO:0001650,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006351,GO:0006355,GO:0008283,GO:0030154,GO:0051726 fibrillar center|nucleus|nucleoplasm|nucleolus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|cell proliferation|cell differentiation|regulation of cell cycle YY2 36.4506668510642 37.5139668866533 35.3873668154751 0.943311778314364 -0.0841934133964327 0.882374092392519 1 0.394617 0.652513 0.731971 0.38001 GeneID:404281,Genbank:NM_206923.3,HGNC:HGNC:31684,MIM:300570 YY2 transcription factor GO:0000987,GO:0001228,GO:0005634,GO:0006357,GO:0043565,GO:0045944,GO:0046872 proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|regulation of transcription from RNA polymerase II promoter|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZACN 103.416031642926 106.055302574928 100.776760710923 0.950228402202932 -0.0736537655276445 0.871688839068049 1 0.960548 1.04548 0.889412 1.10996 GeneID:353174,Genbank:NM_180990.3,HGNC:HGNC:29504,MIM:610935 zinc activated ion channel GO:0004888,GO:0005886,GO:0008270,GO:0010043,GO:0015276,GO:0016021,GO:0022850,GO:0034220 transmembrane signaling receptor activity|plasma membrane|zinc ion binding|response to zinc ion|ligand-gated ion channel activity|integral component of membrane|serotonin-gated cation-selective channel activity|ion transmembrane transport ZADH2 295.835399461133 262.58694255061 329.083856371655 1.25323770167371 0.325660076672502 0.105584398526612 1 1.36608 1.36762 1.86478 1.56054 GeneID:284273,Genbank:NM_175907.5,HGNC:HGNC:28697 zinc binding alcohol dehydrogenase domain containing 2 GO:0005739,GO:0005777,GO:0008270,GO:0036132,GO:0045599,GO:0047522 mitochondrion|peroxisome|zinc ion binding|13-prostaglandin reductase activity|negative regulation of fat cell differentiation|15-oxoprostaglandin 13-oxidase activity ZAN 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.00699768 0 0 0 GeneID:7455,Genbank:XM_011516555.2,HGNC:HGNC:12857,MIM:602372 zonadhesin (gene/pseudogene) GO:0005886,GO:0007339,GO:0016021,GO:0098609 plasma membrane|binding of sperm to zona pellucida|integral component of membrane|cell-cell adhesion ZAP70 1.21430233409962 0.490071401957362 1.93853326624189 3.95561393400904 1.98390162663545 0.683537482026705 1 0 0.00589247 0 0.00579125 GeneID:7535,Genbank:XM_017004869.1,HGNC:HGNC:12858,MIM:176947 zeta chain of T cell receptor associated protein kinase 70 hsa04014,hsa04064,hsa04650,hsa04658,hsa04659,hsa04660,hsa05340 Ras signaling pathway|NF-kappa B signaling pathway|Natural killer cell mediated cytotoxicity|Th1 and Th2 cell differentiation|Th17 cell differentiation|T cell receptor signaling pathway|Primary immunodeficiency ZAR1L 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.0419436 GeneID:646799,Genbank:NM_001136571.1,HGNC:HGNC:37116 zygote arrest 1 like GO:0005737 cytoplasm ZBBX 0.807146514963456 1.61429302992691 0 0 -Inf 0.549240155942477 1 0 0 0 0 GeneID:79740,Genbank:XM_024453753.1,HGNC:HGNC:26245 zinc finger B-box domain containing GO:0005622,GO:0008270 intracellular|zinc ion binding ZBED1 6.74392272638505 6.21704074628294 7.27080470648717 1.16949606785741 0.225887010991616 0.899644645282705 1 0.109637 0.0612487 0.0836119 0.0519625 GeneID:9189,Genbank:NM_004729.3,HGNC:HGNC:447,MIM:300178 zinc finger BED-type containing 1 GO:0000228,GO:0000977,GO:0000978,GO:0001077,GO:0001228,GO:0003700,GO:0004803,GO:0005654,GO:0006357,GO:0019789,GO:0042802,GO:0043565,GO:0045944,GO:0046872,GO:0046983 nuclear chromosome|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|transposase activity|nucleoplasm|regulation of transcription from RNA polymerase II promoter|SUMO transferase activity|identical protein binding|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|protein dimerization activity ZBED3 177.119010409853 188.972405054238 165.265615765468 0.874548935957259 -0.193388981537922 0.40408225135424 1 5.22236 6.13974 5.90755 5.44304 GeneID:84327,Genbank:NM_001329564.1,HGNC:HGNC:20711,MIM:615250 zinc finger BED-type containing 3 GO:0001933,GO:0003677,GO:0005829,GO:0016020,GO:0016055,GO:0045944,GO:0046872,GO:0050821,GO:0090263,GO:1903955 negative regulation of protein phosphorylation|DNA binding|cytosol|membrane|Wnt signaling pathway|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|protein stabilization|positive regulation of canonical Wnt signaling pathway|positive regulation of protein targeting to mitochondrion ZBED4 906.347184114549 826.399016166454 986.295352062644 1.19348563196254 0.255181198324877 0.101267262599482 1 4.61149 4.61775 6.20417 4.9329 GeneID:9889,Genbank:NM_014838.2,HGNC:HGNC:20721,MIM:612552 zinc finger BED-type containing 4 GO:0000977,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0006357,GO:0046872,GO:0046983 RNA polymerase II regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|regulation of transcription from RNA polymerase II promoter|metal ion binding|protein dimerization activity ZBED5 277.645266946097 275.645365614081 279.645168278113 1.01451068351946 0.0207840577800249 0.914277244527121 1 4.6208 4.67208 5.08175 4.25218 GeneID:58486,Genbank:NM_001143667.1,HGNC:HGNC:30803,MIM:615251 zinc finger BED-type containing 5 GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|metal ion binding ZBED6 91.7575077109084 94.3416152026367 89.1734002191801 0.945218078232435 -0.0812808723393933 0.827400248656528 1 1.15281 0.858473 1.05163 0.934636 GeneID:100381270,Genbank:NM_001174108.2,HGNC:HGNC:33273,MIM:613512 zinc finger BED-type containing 6 GO:0000977,GO:0003700,GO:0005634,GO:0005730,GO:0006351,GO:0006357,GO:0045892,GO:0046872,GO:0046983 RNA polymerase II regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleolus|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-templated|metal ion binding|protein dimerization activity ZBED6CL 3.48916150525007 4.55472144167109 2.42360156882906 0.532107528389235 -0.910210279614975 0.632608876472154 1 0.0511798 0.0754796 0.0478976 0.029768 GeneID:113763,Genbank:NM_138434.2,HGNC:HGNC:21720,MIM:615252 ZBED6 C-terminal like ZBED8 61.8639608738954 52.4846492832679 71.2432724645228 1.35741161344171 0.440858261380837 0.228791638909609 1 0.745484 0.752107 1.1472 0.946648 GeneID:63920,Genbank:NM_022090.4,HGNC:HGNC:30804,MIM:615253 zinc finger BED-type containing 8 GO:0000981,GO:0003677,GO:0005654,GO:0005737 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm ZBED9 18.1503526804634 18.8530359926965 17.4476693682304 0.925456747390151 -0.111762529733597 0.896892064196587 1 0.0469431 0.100067 0.081743 0.0675817 GeneID:114821,Genbank:XM_011514288.2,HGNC:HGNC:13851,MIM:615254 zinc finger BED-type containing 9 GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0015074 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|DNA integration ZBP1 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0 0 GeneID:81030,Genbank:NM_001160418.1,HGNC:HGNC:16176,MIM:606750 Z-DNA binding protein 1 GO:0003677,GO:0003692,GO:0003723,GO:0003726,GO:0005634,GO:0005737,GO:0005829,GO:0032479,GO:0032481,GO:0042802,GO:0045087 DNA binding|left-handed Z-DNA binding|RNA binding|double-stranded RNA adenosine deaminase activity|nucleus|cytoplasm|cytosol|regulation of type I interferon production|positive regulation of type I interferon production|identical protein binding|innate immune response hsa04217,hsa04623 Necroptosis|Cytosolic DNA-sensing pathway ZBTB1 331.536921341352 330.090300505178 332.983542177527 1.00876500057082 0.0125901268742791 0.948206492949859 1 2.29816 2.23593 2.71007 1.89147 GeneID:22890,Genbank:NM_014950.2,HGNC:HGNC:20259,MIM:616578 zinc finger and BTB domain containing 1 GO:0000122,GO:0002711,GO:0003677,GO:0005634,GO:0005654,GO:0006281,GO:0006338,GO:0006974,GO:0016604,GO:0019985,GO:0030183,GO:0031965,GO:0032825,GO:0033077,GO:0034644,GO:0042789,GO:0042803,GO:0045087,GO:0045582,GO:0046872,GO:0046982,GO:0048538,GO:0051260,GO:0070530,GO:2000176 negative regulation of transcription from RNA polymerase II promoter|positive regulation of T cell mediated immunity|DNA binding|nucleus|nucleoplasm|DNA repair|chromatin remodeling|cellular response to DNA damage stimulus|nuclear body|translesion synthesis|B cell differentiation|nuclear membrane|positive regulation of natural killer cell differentiation|T cell differentiation in thymus|cellular response to UV|mRNA transcription from RNA polymerase II promoter|protein homodimerization activity|innate immune response|positive regulation of T cell differentiation|metal ion binding|protein heterodimerization activity|thymus development|protein homooligomerization|K63-linked polyubiquitin modification-dependent protein binding|positive regulation of pro-T cell differentiation ZBTB10 91.5569118213356 98.780666784722 84.3331568579492 0.853741522536399 -0.228128747054671 0.666191766500906 1 0.552773 0.325268 0.434798 0.331207 GeneID:65986,Genbank:NM_001277145.1,HGNC:HGNC:30953 zinc finger and BTB domain containing 10 GO:0003677,GO:0005654,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB11 154.381905169231 151.227098448413 157.536711890049 1.04172276996896 0.0589713893189033 0.866197254594664 1 0.833645 0.606151 0.9878 0.565364 GeneID:27107,Genbank:NM_014415.3,HGNC:HGNC:16740 zinc finger and BTB domain containing 11 GO:0003677,GO:0005654,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB12 342.772034085068 294.960064044265 390.584004125871 1.324192837398 0.405113231888163 0.0363551010990245 0.739899327172153 5.31417 5.3436 6.72813 7.44859 GeneID:221527,Genbank:XM_011514383.2,HGNC:HGNC:19066 zinc finger and BTB domain containing 12 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB14 263.787114699636 269.284246043743 258.28998335553 0.959172276693725 -0.0601381342737665 0.791053155817213 1 2.45231 2.29523 2.15813 2.41565 GeneID:7541,Genbank:NM_001243704.1,HGNC:HGNC:12860,MIM:602126 zinc finger and BTB domain containing 14 GO:0000122,GO:0000978,GO:0001078,GO:0003170,GO:0003279,GO:0003700,GO:0005634,GO:0005654,GO:0005730,GO:0005829,GO:0006351,GO:0016235,GO:0043565,GO:0044212,GO:0045892,GO:0046872,GO:0060976 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|heart valve development|cardiac septum development|DNA binding transcription factor activity|nucleus|nucleoplasm|nucleolus|cytosol|transcription, DNA-templated|aggresome|sequence-specific DNA binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|metal ion binding|coronary vasculature development ZBTB16 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 0.00367113 0 0.00347736 0 GeneID:7704,Genbank:XM_024448681.1,HGNC:HGNC:12930,MIM:176797 zinc finger and BTB domain containing 16 hsa05200,hsa05202,hsa05221 Pathways in cancer|Transcriptional misregulation in cancer|Acute myeloid leukemia ZBTB17 774.25569715964 708.669260839665 839.842133479615 1.18509744938637 0.245005695381783 0.13000532964184 1 3.81992 4.33201 5.03147 4.81581 GeneID:7709,Genbank:XM_005245986.2,HGNC:HGNC:12936,MIM:604084 zinc finger and BTB domain containing 17 GO:0000978,GO:0001047,GO:0001077,GO:0001223,GO:0001228,GO:0001702,GO:0003700,GO:0005654,GO:0007398,GO:0008134,GO:0008285,GO:0032993,GO:0036498,GO:0043234,GO:0045786,GO:0045944,GO:0046872,GO:0071158,GO:1903146,GO:1903955 RNA polymerase II proximal promoter sequence-specific DNA binding|core promoter binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|transcription coactivator binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|gastrulation with mouth forming second|DNA binding transcription factor activity|nucleoplasm|ectoderm development|transcription factor binding|negative regulation of cell proliferation|protein-DNA complex|IRE1-mediated unfolded protein response|protein complex|negative regulation of cell cycle|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|positive regulation of cell cycle arrest|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion hsa04110,hsa05200,hsa05202,hsa05222 Cell cycle|Pathways in cancer|Transcriptional misregulation in cancer|Small cell lung cancer ZBTB18 853.985814094072 867.544379619802 840.427248568343 0.968742658371733 -0.0458146230539785 0.782126245886778 1 6.00072 5.83596 6.53039 4.9911 GeneID:10472,Genbank:NM_001278196.1,HGNC:HGNC:13030,MIM:608433 zinc finger and BTB domain containing 18 GO:0000122,GO:0000228,GO:0003677,GO:0003700,GO:0003713,GO:0005634,GO:0006351,GO:0007519,GO:0043565,GO:0045892,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|nuclear chromosome|DNA binding|DNA binding transcription factor activity|transcription coactivator activity|nucleus|transcription, DNA-templated|skeletal muscle tissue development|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZBTB2 463.884460085891 500.767384553577 427.001535618205 0.852694382240703 -0.229899343063708 0.187626657180674 1 4.09085 4.66534 4.2555 3.09403 GeneID:57621,Genbank:XM_017011137.1,HGNC:HGNC:20868,MIM:616595 zinc finger and BTB domain containing 2 GO:0000122,GO:0000978,GO:0001078,GO:0005634,GO:0006351,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZBTB20 146.928540140688 116.413428600079 177.443651681298 1.52425415018811 0.608103474121429 0.436662864939136 1 0.189052 0.139627 0.372753 0.133145 GeneID:26137,Genbank:NM_015642.5,HGNC:HGNC:13503,MIM:606025 zinc finger and BTB domain containing 20 GO:0001078,GO:0003677,GO:0005634,GO:0005654,GO:0006351,GO:0016604,GO:0032728,GO:0032755,GO:0032760,GO:0046872 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|nuclear body|positive regulation of interferon-beta production|positive regulation of interleukin-6 production|positive regulation of tumor necrosis factor production|metal ion binding ZBTB21 228.973842556234 218.980396431513 238.967288680956 1.09127251834021 0.126011424083873 0.716762926256274 1 1.11882 0.877514 1.35325 0.867196 GeneID:49854,Genbank:XM_011529588.2,HGNC:HGNC:13083,MIM:616485 zinc finger and BTB domain containing 21 GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0008327,GO:0045892,GO:0046872 nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|methyl-CpG binding|negative regulation of transcription, DNA-templated|metal ion binding ZBTB22 699.446061027164 704.479132285258 694.412989769071 0.985711226841406 -0.0207630371513011 0.90003178011709 1 10.4549 10.281 9.64945 11.134 GeneID:9278,Genbank:NM_001145338.1,HGNC:HGNC:13085,MIM:611439 zinc finger and BTB domain containing 22 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB24 355.371504495003 388.436189301718 322.306819688289 0.829754869822226 -0.269242903397576 0.167710791509192 1 3.06958 2.59392 2.57606 2.06503 GeneID:9841,Genbank:NM_014797.2,HGNC:HGNC:21143,MIM:614064 zinc finger and BTB domain containing 24 ZBTB25 166.768734627602 178.949445951027 154.588023304176 0.863864218649117 -0.211123526104803 0.398519193000704 1 0.540296 0.684428 0.701059 0.679623 GeneID:7597,Genbank:NM_001304508.1,HGNC:HGNC:13112,MIM:194541 zinc finger and BTB domain containing 25 GO:0003677,GO:0003700,GO:0005654,GO:0005737,GO:0006351,GO:0010467,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleoplasm|cytoplasm|transcription, DNA-templated|gene expression|metal ion binding ZBTB26 58.9122807333592 58.2116186275935 59.6129428391249 1.0240729298475 0.0343184612194971 0.938719260007873 1 0.984021 0.778093 0.909362 0.70028 GeneID:57684,Genbank:NM_020924.3,HGNC:HGNC:23383 zinc finger and BTB domain containing 26 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0042802,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|identical protein binding|metal ion binding ZBTB3 54.8349623287623 55.8769314773925 53.7929931801322 0.962704854361887 -0.0548345298543037 0.881843667617548 1 0.645425 0.96824 0.805404 0.810953 GeneID:79842,Genbank:NM_024784.3,HGNC:HGNC:22918 zinc finger and BTB domain containing 3 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB33 320.132274881627 340.246512776481 300.018036986774 0.881766677161702 -0.181531137781677 0.51714126333414 1 3.03829 2.33567 2.78265 2.03541 GeneID:10009,Genbank:NM_006777.3,HGNC:HGNC:16682,MIM:300329 zinc finger and BTB domain containing 33 ZBTB34 137.131562252187 153.571594253722 120.691530250652 0.785897488641374 -0.347586953235234 0.342219251984646 1 1.22588 0.900601 1.02018 0.66069 GeneID:403341,Genbank:NM_001099270.1,HGNC:HGNC:31446,MIM:611692 zinc finger and BTB domain containing 34 GO:0003677,GO:0005654,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB37 103.254586641085 85.3282248686644 121.180948413506 1.42017425769756 0.506067961625621 0.216686980200113 1 0.203319 0.144286 0.320516 0.193416 GeneID:84614,Genbank:NM_001346115.1,HGNC:HGNC:28365 zinc finger and BTB domain containing 37 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB38 870.737960429309 832.614022911027 908.86189794759 1.0915764963578 0.126413236191252 0.714650284818993 1 2.30541 1.85271 2.8294 1.72801 GeneID:253461,Genbank:NM_001080412.2,HGNC:HGNC:26636,MIM:612218 zinc finger and BTB domain containing 38 GO:0003700,GO:0005634,GO:0005654,GO:0005694,GO:0006275,GO:0006351,GO:0006974,GO:0008327,GO:0042803,GO:0045892,GO:0045944,GO:0046872,GO:0072562 DNA binding transcription factor activity|nucleus|nucleoplasm|chromosome|regulation of DNA replication|transcription, DNA-templated|cellular response to DNA damage stimulus|methyl-CpG binding|protein homodimerization activity|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|blood microparticle ZBTB39 227.316136990313 250.10483478336 204.527439197267 0.817766835153058 -0.290238539886159 0.182418941575212 1 1.5849 1.64831 1.49345 1.21916 GeneID:9880,Genbank:NM_014830.2,HGNC:HGNC:29014 zinc finger and BTB domain containing 39 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB4 3738.4762004058 3410.35465782425 4066.59774298735 1.1924266391642 0.253900511036141 0.0608647461110532 0.88260138524454 19.7024 20.1367 25.1044 23.0983 GeneID:57659,Genbank:NM_020899.3,HGNC:HGNC:23847,MIM:612308 zinc finger and BTB domain containing 4 GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0005654,GO:0005694,GO:0005829,GO:0006351,GO:0006974,GO:0008327,GO:0010428,GO:0016604,GO:0019901,GO:0042803,GO:0043565,GO:0045892,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|nucleoplasm|chromosome|cytosol|transcription, DNA-templated|cellular response to DNA damage stimulus|methyl-CpG binding|methyl-CpNpG binding|nuclear body|protein kinase binding|protein homodimerization activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding ZBTB40 667.446079529153 681.129209780683 653.762949277622 0.959822218589226 -0.0591608850032091 0.71581533628471 1 2.26556 2.34931 2.26989 2.15833 GeneID:9923,Genbank:XM_011542499.2,HGNC:HGNC:29045,MIM:612106 zinc finger and BTB domain containing 40 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0006974,GO:0030282,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to DNA damage stimulus|bone mineralization|metal ion binding ZBTB41 54.3964358082879 69.5214784921898 39.271393124386 0.564881443492285 -0.823979986356702 0.113869117608422 1 0.322643 0.296619 0.258399 0.0960117 GeneID:360023,Genbank:XM_024446754.1,HGNC:HGNC:24819 zinc finger and BTB domain containing 41 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB42 120.038457911855 110.177787544435 129.899128279274 1.17899561403777 0.237558351381521 0.433578971121195 1 1.31332 1.55291 2.08748 1.38173 GeneID:100128927,Genbank:XM_017020911.1,HGNC:HGNC:32550,MIM:613915 zinc finger and BTB domain containing 42 GO:0000122,GO:0003677,GO:0005634,GO:0005654,GO:0005737,GO:0005886,GO:0006351,GO:0007517,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|nucleus|nucleoplasm|cytoplasm|plasma membrane|transcription, DNA-templated|muscle organ development|metal ion binding ZBTB43 207.952111819076 199.272696149596 216.631527488557 1.08711093729535 0.120499171753684 0.593710656659369 1 1.20255 1.1468 1.37463 1.31697 GeneID:23099,Genbank:XM_011518409.1,HGNC:HGNC:17908 zinc finger and BTB domain containing 43 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB44 357.638260104642 339.141908458727 376.134611750557 1.10907735779381 0.149359996530514 0.593562224372568 1 1.62082 1.53711 2.13966 1.39373 GeneID:29068,Genbank:NM_001301099.1,HGNC:HGNC:25001 zinc finger and BTB domain containing 44 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB45 358.504411160844 354.037172617043 362.971649704645 1.0252359858756 0.0359560233569604 0.89083572706664 1 5.50689 6.54499 6.30848 6.59447 GeneID:84878,Genbank:NM_001316980.1,HGNC:HGNC:23715 zinc finger and BTB domain containing 45 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0007399,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|nervous system development|metal ion binding ZBTB46 184.792143504088 158.299820484772 211.284466523404 1.33471071461973 0.416527085876453 0.0773264201545495 0.94157495521624 0.996119 0.991504 1.29783 1.37734 GeneID:140685,Genbank:NM_025224.3,HGNC:HGNC:16094,MIM:614639 zinc finger and BTB domain containing 46 GO:0003676,GO:0005634,GO:0006351,GO:0006355,GO:0030853,GO:0045650,GO:0045656,GO:0046872,GO:2001199,GO:2001200 nucleic acid binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation|negative regulation of monocyte differentiation|metal ion binding|negative regulation of dendritic cell differentiation|positive regulation of dendritic cell differentiation ZBTB47 865.73565584779 846.982015048663 884.489296646916 1.04428344514033 0.0625133492612228 0.70425508932286 1 5.71801 6.03758 6.83081 5.82578 GeneID:92999,Genbank:NM_145166.3,HGNC:HGNC:26955 zinc finger and BTB domain containing 47 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB48 388.937868578033 388.254909858941 389.620827297124 1.00351809443615 0.00506663017133489 1 1 4.01606 4.33139 4.13495 4.39129 GeneID:3104,Genbank:NM_005341.3,HGNC:HGNC:4930,MIM:165270 zinc finger and BTB domain containing 48 GO:0000781,GO:0003691,GO:0003700,GO:0005654,GO:0005829,GO:0006351,GO:0010833,GO:0042802,GO:0044212,GO:0045893,GO:0046872 chromosome, telomeric region|double-stranded telomeric DNA binding|DNA binding transcription factor activity|nucleoplasm|cytosol|transcription, DNA-templated|telomere maintenance via telomere lengthening|identical protein binding|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|metal ion binding ZBTB49 94.4697226233179 93.9574050051571 94.9820402414786 1.01090531647043 0.0156478777004099 0.974940850163319 1 0.94419 1.03372 1.07376 1.12076 GeneID:166793,Genbank:NM_145291.3,HGNC:HGNC:19883,MIM:616238 zinc finger and BTB domain containing 49 GO:0001223,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0007050,GO:0008134,GO:0008285,GO:0015630,GO:0043565,GO:0045944,GO:0046872 transcription coactivator binding|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|cell cycle arrest|transcription factor binding|negative regulation of cell proliferation|microtubule cytoskeleton|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZBTB5 728.425696218659 666.427067721962 790.424324715355 1.18606275615012 0.246180346807426 0.126420140345921 1 4.68099 4.80827 5.75289 5.52766 GeneID:9925,Genbank:NM_014872.2,HGNC:HGNC:23836,MIM:616590 zinc finger and BTB domain containing 5 GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0006351,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZBTB6 110.070635540042 116.903500002036 103.237771078048 0.883102482613861 -0.179347224873736 0.613440838818795 1 1.49591 1.13264 1.31444 1.01224 GeneID:10773,Genbank:NM_006626.5,HGNC:HGNC:16764,MIM:605976 zinc finger and BTB domain containing 6 GO:0003677,GO:0005634,GO:0005739,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|mitochondrion|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB7A 1911.91126301461 1665.71339357318 2158.10913245605 1.29560651957454 0.373627632997357 0.00863332101248083 0.362097302226572 9.23297 9.33694 13.0219 11.6729 GeneID:51341,Genbank:NM_015898.3,HGNC:HGNC:18078,MIM:605878 zinc finger and BTB domain containing 7A ZBTB7B 1465.40728734335 1518.69400698768 1412.12056769902 0.929825600945087 -0.104967946672929 0.465806299137365 1 11.7622 11.3092 10.5722 11.2289 GeneID:51043,Genbank:XM_006711359.2,HGNC:HGNC:18668,MIM:607646 zinc finger and BTB domain containing 7B GO:0000978,GO:0001077,GO:0005634,GO:0005654,GO:0006366,GO:0007275,GO:0007398,GO:0010628,GO:0010629,GO:0030154,GO:0042803,GO:0043376,GO:0046872,GO:2000320 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|nucleoplasm|transcription from RNA polymerase II promoter|multicellular organism development|ectoderm development|positive regulation of gene expression|negative regulation of gene expression|cell differentiation|protein homodimerization activity|regulation of CD8-positive, alpha-beta T cell differentiation|metal ion binding|negative regulation of T-helper 17 cell differentiation ZBTB7C 4.38051565492001 3.43049981370153 5.33053149613849 1.55386438875413 0.635860600136225 0.759018774438733 1 0 0.0263202 0.0228473 0.0256343 GeneID:201501,Genbank:XM_017025608.1,HGNC:HGNC:31700,MIM:616591 zinc finger and BTB domain containing 7C GO:0003676,GO:0005634,GO:0008285,GO:0045600,GO:0045944,GO:0046872,GO:1903025 nucleic acid binding|nucleus|negative regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|regulation of RNA polymerase II regulatory region sequence-specific DNA binding ZBTB8A 152.932294755301 162.402688144062 143.46190136654 0.883371470053991 -0.178907855984825 0.489575882114123 1 0.935551 0.88326 0.870081 0.697288 GeneID:653121,Genbank:NM_001040441.2,HGNC:HGNC:24172 zinc finger and BTB domain containing 8A GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB8B 61.0505417085301 58.1155660782236 63.9855173388366 1.10100480227125 0.138820761543348 0.72963081662982 1 0.641584 0.585082 0.873074 0.43633 GeneID:728116,Genbank:NM_001145720.1,HGNC:HGNC:37057 zinc finger and BTB domain containing 8B GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZBTB8OS 628.282195760091 609.637637025556 646.926754494625 1.06116603569787 0.0856504056750919 0.611063394022383 1 3.18487 3.00477 3.48336 3.84628 GeneID:339487,Genbank:XM_017001136.2,HGNC:HGNC:24094,MIM:615891 zinc finger and BTB domain containing 8 opposite strand GO:0005654,GO:0006388,GO:0046872,GO:0070062,GO:0072669 nucleoplasm|tRNA splicing, via endonucleolytic cleavage and ligation|metal ion binding|extracellular exosome|tRNA-splicing ligase complex ZBTB9 492.537195087359 520.350623321656 464.723766853063 0.893097357867087 -0.163110640642759 0.342207180832745 1 7.77007 8.51899 6.91681 7.78054 GeneID:221504,Genbank:NM_152735.3,HGNC:HGNC:28323 zinc finger and BTB domain containing 9 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZC2HC1A 109.368519601291 102.903151754229 115.833887448353 1.12565927742435 0.170770208273417 0.533822296621584 1 0.429623 0.311736 0.463416 0.359057 GeneID:51101,Genbank:NM_016010.2,HGNC:HGNC:24277 zinc finger C2HC-type containing 1A GO:0046872 metal ion binding ZC2HC1C 21.5162712093592 18.3149383160542 24.7176041026641 1.34958707892549 0.43251806630528 0.510540652265527 1 0.0869606 0.123129 0.199712 0.131872 GeneID:79696,Genbank:NM_024643.3,HGNC:HGNC:20354 zinc finger C2HC-type containing 1C GO:0046872 metal ion binding ZC3H10 156.9376055721 164.132651033575 149.742560110625 0.912326457701543 -0.132377938664175 0.589888476657644 1 2.17515 2.43816 2.13273 2.19018 GeneID:84872,Genbank:NM_001303124.1,HGNC:HGNC:25893 zinc finger CCCH-type containing 10 GO:0003723,GO:0005634,GO:0010608,GO:0035198,GO:0046872,GO:1903799 RNA binding|nucleus|posttranscriptional regulation of gene expression|miRNA binding|metal ion binding|negative regulation of production of miRNAs involved in gene silencing by miRNA ZC3H11A 1471.59501390989 1549.21844472967 1393.97158309011 0.899790205721024 -0.152339431720805 0.555998333383339 1 9.5966 8.03041 9.22318 6.54696 GeneID:9877,Genbank:NM_001319238.1,HGNC:HGNC:29093,MIM:613513 zinc finger CCCH-type containing 11A GO:0003723,GO:0005654,GO:0006369,GO:0006405,GO:0006406,GO:0016973,GO:0031124,GO:0046872 RNA binding|nucleoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|metal ion binding ZC3H11B 19.7470264961196 19.1411936408062 20.352859351433 1.06330147081547 0.0885506926245726 0.91613147907222 1 0.222096 0.168086 0.201644 0.256919 GeneID:643136,Genbank:NM_001355457.1,HGNC:HGNC:25659 zinc finger CCCH-type containing 11B GO:0003723,GO:0005654,GO:0006369,GO:0006405,GO:0006406,GO:0016973,GO:0031124,GO:0046872 RNA binding|nucleoplasm|termination of RNA polymerase II transcription|RNA export from nucleus|mRNA export from nucleus|poly(A)+ mRNA export from nucleus|mRNA 3'-end processing|metal ion binding ZC3H12A 200.58693776563 218.942178811936 182.231696719325 0.832327958496547 -0.2647759957651 0.258391545588188 1 3.07116 2.49277 2.7867 2.19199 GeneID:80149,Genbank:NM_001323551.1,HGNC:HGNC:26259,MIM:610562 zinc finger CCCH-type containing 12A GO:0000294,GO:0000932,GO:0001525,GO:0001933,GO:0002230,GO:0003677,GO:0003682,GO:0003723,GO:0003729,GO:0003730,GO:0004521,GO:0004532,GO:0004540,GO:0005634,GO:0005654,GO:0005737,GO:0005791,GO:0005856,GO:0006351,GO:0006915,GO:0006954,GO:0006974,GO:0007399,GO:0010468,GO:0010508,GO:0010595,GO:0010628,GO:0010629,GO:0010656,GO:0010884,GO:0010942,GO:0016579,GO:0030154,GO:0030867,GO:0032088,GO:0032715,GO:0032720,GO:0034599,GO:0035198,GO:0035613,GO:0035925,GO:0036464,GO:0042149,GO:0042307,GO:0042347,GO:0042406,GO:0043022,GO:0043031,GO:0043124,GO:0043234,GO:0044828,GO:0045019,GO:0045600,GO:0045766,GO:0045944,GO:0046872,GO:0050713,GO:0051259,GO:0051607,GO:0055118,GO:0061014,GO:0061158,GO:0071222,GO:0071347,GO:0071356,GO:0090501,GO:0090502,GO:0098586,GO:1900016,GO:1900119,GO:1900165,GO:1900745,GO:1902714,GO:1903003,GO:1903799,GO:1903936,GO:1904468,GO:1904628,GO:1904637,GO:1990869,GO:2000379,GO:2000627 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay|P-body|angiogenesis|negative regulation of protein phosphorylation|positive regulation of defense response to virus by host|DNA binding|chromatin binding|RNA binding|mRNA binding|mRNA 3'-UTR binding|endoribonuclease activity|exoribonuclease activity|ribonuclease activity|nucleus|nucleoplasm|cytoplasm|rough endoplasmic reticulum|cytoskeleton|transcription, DNA-templated|apoptotic process|inflammatory response|cellular response to DNA damage stimulus|nervous system development|regulation of gene expression|positive regulation of autophagy|positive regulation of endothelial cell migration|positive regulation of gene expression|negative regulation of gene expression|negative regulation of muscle cell apoptotic process|positive regulation of lipid storage|positive regulation of cell death|protein deubiquitination|cell differentiation|rough endoplasmic reticulum membrane|negative regulation of NF-kappaB transcription factor activity|negative regulation of interleukin-6 production|negative regulation of tumor necrosis factor production|cellular response to oxidative stress|miRNA binding|RNA stem-loop binding|mRNA 3'-UTR AU-rich region binding|cytoplasmic ribonucleoprotein granule|cellular response to glucose starvation|positive regulation of protein import into nucleus|negative regulation of NF-kappaB import into nucleus|extrinsic component of endoplasmic reticulum membrane|ribosome binding|negative regulation of macrophage activation|negative regulation of I-kappaB kinase/NF-kappaB signaling|protein complex|negative regulation by host of viral genome replication|negative regulation of nitric oxide biosynthetic process|positive regulation of fat cell differentiation|positive regulation of angiogenesis|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|negative regulation of interleukin-1 beta secretion|protein oligomerization|defense response to virus|negative regulation of cardiac muscle contraction|positive regulation of mRNA catabolic process|3'-UTR-mediated mRNA destabilization|cellular response to lipopolysaccharide|cellular response to interleukin-1|cellular response to tumor necrosis factor|RNA phosphodiester bond hydrolysis|RNA phosphodiester bond hydrolysis, endonucleolytic|cellular response to virus|negative regulation of cytokine production involved in inflammatory response|positive regulation of execution phase of apoptosis|negative regulation of interleukin-6 secretion|positive regulation of p38MAPK cascade|negative regulation of interferon-gamma secretion|positive regulation of protein deubiquitination|negative regulation of production of miRNAs involved in gene silencing by miRNA|cellular response to sodium arsenite|negative regulation of tumor necrosis factor secretion|cellular response to phorbol 13-acetate 12-myristate|cellular response to ionomycin|cellular response to chemokine|positive regulation of reactive oxygen species metabolic process|positive regulation of miRNA catabolic process ZC3H12B 89.5379353980321 81.1773309346887 97.8985398613754 1.2059837239554 0.270210436651523 0.388779958063787 1 0.248857 0.250406 0.306127 0.279269 GeneID:340554,Genbank:XM_017029484.1,HGNC:HGNC:17407,MIM:300889 zinc finger CCCH-type containing 12B GO:0004519,GO:0046872 endonuclease activity|metal ion binding ZC3H12C 174.170974085524 192.757689100095 155.584259070953 0.807149430963353 -0.309092304466548 0.202513728733842 1 0.637978 0.606734 0.599344 0.417379 GeneID:85463,Genbank:XM_011543055.2,HGNC:HGNC:29362,MIM:615001 zinc finger CCCH-type containing 12C GO:0004519,GO:0046872 endonuclease activity|metal ion binding ZC3H12D 1.24375355683899 1.51824048055703 0.969266633120943 0.638414431398462 -0.647434830746163 0.97445271569056 1 0.0103912 0.0182932 0.00969477 0.00907504 GeneID:340152,Genbank:NM_207360.2,HGNC:HGNC:21175,MIM:611106 zinc finger CCCH-type containing 12D GO:0000932,GO:0004519,GO:0005634,GO:0005654,GO:0005737,GO:0030308,GO:0036464,GO:0046872,GO:0061158,GO:2000134 P-body|endonuclease activity|nucleus|nucleoplasm|cytoplasm|negative regulation of cell growth|cytoplasmic ribonucleoprotein granule|metal ion binding|3'-UTR-mediated mRNA destabilization|negative regulation of G1/S transition of mitotic cell cycle ZC3H13 319.865335817262 342.620434547114 297.110237087411 0.867170218495989 -0.205612884281752 0.306254108834695 1 0.755289 0.699539 0.693641 0.54589 GeneID:23091,Genbank:NM_001330565.1,HGNC:HGNC:20368,MIM:616453 zinc finger CCCH-type containing 13 GO:0003723,GO:0005654,GO:0016607,GO:0046872 RNA binding|nucleoplasm|nuclear speck|metal ion binding ZC3H14 650.163831529288 668.319709744891 632.007953313685 0.945667087321026 -0.0805957083649754 0.63648475541981 1 1.93853 1.94813 2.11311 1.70514 GeneID:79882,Genbank:NM_001326297.1,HGNC:HGNC:20509,MIM:613279 zinc finger CCCH-type containing 14 GO:0003723,GO:0005634,GO:0005730,GO:0005737,GO:0008143,GO:0016607,GO:0030529,GO:0032839,GO:0043488,GO:0046872,GO:1900364,GO:1904115 RNA binding|nucleus|nucleolus|cytoplasm|poly(A) binding|nuclear speck|intracellular ribonucleoprotein complex|dendrite cytoplasm|regulation of mRNA stability|metal ion binding|negative regulation of mRNA polyadenylation|axon cytoplasm ZC3H15 598.555267138797 661.553745666003 535.55678861159 0.809543883804076 -0.304818806539258 0.19456305373724 1 10.6964 8.85203 8.8822 6.9834 GeneID:55854,Genbank:NM_018471.2,HGNC:HGNC:29528 zinc finger CCCH-type containing 15 GO:0003723,GO:0005730,GO:0005829,GO:0019221,GO:0045296,GO:0046872 RNA binding|nucleolus|cytosol|cytokine-mediated signaling pathway|cadherin binding|metal ion binding ZC3H18 1830.52969386164 1772.94973570501 1888.10965201826 1.06495385288938 0.090790916225687 0.526125353354935 1 12.426 12.6142 14.1077 13.3173 GeneID:124245,Genbank:NM_001294340.1,HGNC:HGNC:25091 zinc finger CCCH-type containing 18 GO:0003723,GO:0016607,GO:0043234,GO:0046872 RNA binding|nuclear speck|protein complex|metal ion binding ZC3H3 413.751415343465 386.976800751809 440.526029935121 1.1383783965325 0.186980188629211 0.321293435685882 1 2.88756 3.17185 3.67846 3.38175 GeneID:23144,Genbank:XM_017013248.1,HGNC:HGNC:28972 zinc finger CCCH-type containing 3 GO:0003677,GO:0003723,GO:0004521,GO:0005634,GO:0005847,GO:0006378,GO:0010793,GO:0016973,GO:0032927,GO:0046872,GO:0070412 DNA binding|RNA binding|endoribonuclease activity|nucleus|mRNA cleavage and polyadenylation specificity factor complex|mRNA polyadenylation|regulation of mRNA export from nucleus|poly(A)+ mRNA export from nucleus|positive regulation of activin receptor signaling pathway|metal ion binding|R-SMAD binding ZC3H4 1229.0868991347 1270.3475440583 1187.8262542111 0.935040383056456 -0.0968994206066881 0.51086241113954 1 4.08963 4.01445 3.86782 3.66908 GeneID:23211,Genbank:XM_017026530.2,HGNC:HGNC:17808 zinc finger CCCH-type containing 4 GO:0003723,GO:0005654,GO:0005829,GO:0046872 RNA binding|nucleoplasm|cytosol|metal ion binding ZC3H6 56.4982470657079 53.8686195948781 59.1278745365377 1.09763114371989 0.134393321620456 0.772684455010815 1 0.176174 0.279318 0.252461 0.23512 GeneID:376940,Genbank:XM_006712519.3,HGNC:HGNC:24762 zinc finger CCCH-type containing 6 GO:0046872 metal ion binding ZC3H7A 1070.45024588157 1075.59033472994 1065.3101570332 0.990442292604532 -0.0138551748948511 0.93640418326957 1 7.09537 7.00051 7.98966 6.20148 GeneID:29066,Genbank:NM_014153.3,HGNC:HGNC:30959 zinc finger CCCH-type containing 7A GO:0003723,GO:0005634,GO:0010608,GO:0035196,GO:0035198,GO:0046872 RNA binding|nucleus|posttranscriptional regulation of gene expression|production of miRNAs involved in gene silencing by miRNA|miRNA binding|metal ion binding ZC3H7B 3906.85802963986 4118.10161078979 3695.61444848993 0.897407300200434 -0.156165174835523 0.239199020408548 1 24.8006 25.315 22.3963 23.3771 GeneID:23264,Genbank:NM_017590.5,HGNC:HGNC:30869 zinc finger CCCH-type containing 7B GO:0003723,GO:0005634,GO:0010608,GO:0016032,GO:0035196,GO:0035198,GO:0046872 RNA binding|nucleus|posttranscriptional regulation of gene expression|viral process|production of miRNAs involved in gene silencing by miRNA|miRNA binding|metal ion binding ZC3H8 90.8382609567042 103.643163184719 78.0333587286898 0.752904063624673 -0.409462049048032 0.196839789732422 1 1.14402 1.02029 1.14647 0.74543 GeneID:84524,Genbank:XM_017005107.1,HGNC:HGNC:30941 zinc finger CCCH-type containing 8 GO:0001162,GO:0001227,GO:0003700,GO:0003723,GO:0005634,GO:0005654,GO:0006915,GO:0008023,GO:0015030,GO:0016604,GO:0033085,GO:0035327,GO:0035363,GO:0042795,GO:0042796,GO:0043029,GO:0043565,GO:0045892,GO:0045945,GO:0046677,GO:0046872,GO:0070245 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|RNA binding|nucleus|nucleoplasm|apoptotic process|transcription elongation factor complex|Cajal body|nuclear body|negative regulation of T cell differentiation in thymus|transcriptionally active chromatin|histone locus body|snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter|T cell homeostasis|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase III promoter|response to antibiotic|metal ion binding|positive regulation of thymocyte apoptotic process ZC3HAV1 1353.65100666337 1258.75831819985 1448.54369512688 1.15077189495633 0.202601892002961 0.713962004643385 1 5.80231 5.74231 9.46551 4.14742 GeneID:56829,Genbank:XM_005250501.3,HGNC:HGNC:23721,MIM:607312 zinc finger CCCH-type containing, antiviral 1 GO:0003723,GO:0005634,GO:0005737,GO:0005829,GO:0009615,GO:0032727,GO:0032728,GO:0043123,GO:0045071,GO:0045087,GO:0045296,GO:0046872,GO:0051607,GO:0061014,GO:1900246 RNA binding|nucleus|cytoplasm|cytosol|response to virus|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of viral genome replication|innate immune response|cadherin binding|metal ion binding|defense response to virus|positive regulation of mRNA catabolic process|positive regulation of RIG-I signaling pathway ZC3HC1 1113.75106036153 1116.30447871198 1111.19764201108 0.995425229587183 -0.00661514152820902 0.965696596399342 1 5.56917 5.82296 5.78754 5.96097 GeneID:51530,Genbank:NM_001282191.1,HGNC:HGNC:29913 zinc finger C3HC-type containing 1 GO:0005634,GO:0007049,GO:0008270,GO:0016567,GO:0019901,GO:0031965,GO:0051301,GO:2001240 nucleus|cell cycle|zinc ion binding|protein ubiquitination|protein kinase binding|nuclear membrane|cell division|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ZC4H2 586.56604667572 556.701133959908 616.430959391531 1.10729244434398 0.147036299161322 0.382693544098512 1 6.35153 6.57457 7.35248 7.43005 GeneID:55906,Genbank:NM_001243804.1,HGNC:HGNC:24931,MIM:300897 zinc finger C4H2-type containing GO:0005634,GO:0005737,GO:0007399,GO:0007528,GO:0021522,GO:0030054,GO:0045211,GO:0045666,GO:0046872 nucleus|cytoplasm|nervous system development|neuromuscular junction development|spinal cord motor neuron differentiation|cell junction|postsynaptic membrane|positive regulation of neuron differentiation|metal ion binding ZCCHC10 265.530146699217 290.193620193639 240.866673204795 0.830020567109885 -0.268781009391882 0.19943011941357 1 4.883 4.84846 4.17906 3.80154 GeneID:54819,Genbank:XM_011543503.2,HGNC:HGNC:25954 zinc finger CCHC-type containing 10 GO:0003676,GO:0008270 nucleic acid binding|zinc ion binding ZCCHC11 368.848936026857 392.568482926333 345.129389127381 0.879157151268677 -0.185807021564972 0.563592991483536 1 1.49629 1.62973 1.70328 1.0269 GeneID:23318,Genbank:XM_017000814.2,HGNC:HGNC:28981,MIM:613692 zinc finger CCHC-type containing 11 GO:0000289,GO:0003723,GO:0005615,GO:0005730,GO:0005737,GO:0005829,GO:0008270,GO:0010586,GO:0010587,GO:0019827,GO:0031054,GO:0031123,GO:0050265,GO:0070062 nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|extracellular space|nucleolus|cytoplasm|cytosol|zinc ion binding|miRNA metabolic process|miRNA catabolic process|stem cell population maintenance|pre-miRNA processing|RNA 3'-end processing|RNA uridylyltransferase activity|extracellular exosome ZCCHC12 16.7954418158637 19.5352124933937 14.0556711383338 0.719504389475521 -0.474924606455148 0.517784035316037 1 0.380764 0.328505 0.265242 0.194219 GeneID:170261,Genbank:NM_173798.3,HGNC:HGNC:27273,MIM:300701 zinc finger CCHC-type containing 12 GO:0003676,GO:0006351,GO:0008270,GO:0016607,GO:0030374,GO:0030509 nucleic acid binding|transcription, DNA-templated|zinc ion binding|nuclear speck|ligand-dependent nuclear receptor transcription coactivator activity|BMP signaling pathway ZCCHC14 975.338581107424 965.806566038097 984.870596176752 1.01973897342286 0.0281999071557773 0.858595147667101 1 4.54218 4.25578 5.2882 3.94355 GeneID:23174,Genbank:NM_015144.2,HGNC:HGNC:24134 zinc finger CCHC-type containing 14 GO:0003676,GO:0008270,GO:0035091 nucleic acid binding|zinc ion binding|phosphatidylinositol binding ZCCHC17 1150.93712704816 1149.5136641855 1152.36058991082 1.00247663495792 0.0035686117194259 0.990961958613176 1 10.0252 10.7824 9.84457 10.9215 GeneID:51538,Genbank:NM_001282568.1,HGNC:HGNC:30246 zinc finger CCHC-type containing 17 GO:0003723,GO:0005730,GO:0008270,GO:0030529 RNA binding|nucleolus|zinc ion binding|intracellular ribonucleoprotein complex ZCCHC18 42.8751116865743 43.5771201537735 42.1731032193751 0.967780869193652 -0.0472476741601877 0.940213213382741 1 0.152315 0.177093 0.203835 0.0995632 GeneID:644353,Genbank:XM_011531012.3,HGNC:HGNC:32459 zinc finger CCHC-type containing 18 GO:0003676,GO:0008270,GO:0016607,GO:0030374,GO:0030509 nucleic acid binding|zinc ion binding|nuclear speck|ligand-dependent nuclear receptor transcription coactivator activity|BMP signaling pathway ZCCHC2 73.4986853612676 59.2495963613011 87.7477743612341 1.48098518386779 0.566557207630557 0.404023084453036 1 0.272688 0.370928 0.699888 0.265495 GeneID:54877,Genbank:NM_017742.5,HGNC:HGNC:22916 zinc finger CCHC-type containing 2 GO:0003676,GO:0005737,GO:0008270,GO:0035091 nucleic acid binding|cytoplasm|zinc ion binding|phosphatidylinositol binding ZCCHC24 442.549619367486 430.102067123202 454.997171611771 1.0578818526846 0.0811785120796623 0.777039364748978 1 3.40977 3.5682 3.1158 4.23677 GeneID:219654,Genbank:NM_153367.3,HGNC:HGNC:26911 zinc finger CCHC-type containing 24 GO:0003723,GO:0008270 RNA binding|zinc ion binding ZCCHC3 384.245234387643 376.44516993728 392.045298838006 1.04144064035494 0.0585806115282654 0.776685189098138 1 6.16337 6.84113 6.63948 7.05001 GeneID:85364,Genbank:NM_033089.6,HGNC:HGNC:16230 zinc finger CCHC-type containing 3 GO:0003723,GO:0008270 RNA binding|zinc ion binding ZCCHC4 276.758903884525 301.993551460192 251.524256308858 0.832879560151843 -0.263820207380966 0.201975185891763 1 1.65534 1.67051 1.46712 1.39777 GeneID:29063,Genbank:NM_024936.2,HGNC:HGNC:22917,MIM:611792 zinc finger CCHC-type containing 4 GO:0003676,GO:0008168,GO:0008270,GO:0016746 nucleic acid binding|methyltransferase activity|zinc ion binding|transferase activity, transferring acyl groups ZCCHC6 175.276404825084 172.174690217886 178.378119432283 1.03602985552956 0.0510655781246754 0.880877995384479 1 0.500904 0.347604 0.522179 0.332432 GeneID:79670,Genbank:NM_001185059.1,HGNC:HGNC:25817,MIM:613467 zinc finger CCHC-type containing 6 GO:0000289,GO:0003723,GO:0005654,GO:0005829,GO:0008270,GO:0031123,GO:0050265 nuclear-transcribed mRNA poly(A) tail shortening|RNA binding|nucleoplasm|cytosol|zinc ion binding|RNA 3'-end processing|RNA uridylyltransferase activity ZCCHC7 264.430412538404 275.395425585548 253.46539949126 0.920368952942265 -0.11971577733112 0.587190599525666 1 1.12986 0.992398 0.961952 0.956442 GeneID:84186,Genbank:XM_005251612.3,HGNC:HGNC:26209 zinc finger CCHC-type containing 7 GO:0003723,GO:0005730,GO:0005829,GO:0008270 RNA binding|nucleolus|cytosol|zinc ion binding hsa03018 RNA degradation ZCCHC8 432.51988318101 470.545636765637 394.494129596384 0.838375916750597 -0.254330820382608 0.168709679737088 1 3.34477 3.03139 2.8275 2.57092 GeneID:55596,Genbank:NM_001350938.1,HGNC:HGNC:25265,MIM:616381 zinc finger CCHC-type containing 8 GO:0000398,GO:0003723,GO:0005634,GO:0005654,GO:0008270,GO:0016604,GO:0071013 mRNA splicing, via spliceosome|RNA binding|nucleus|nucleoplasm|zinc ion binding|nuclear body|catalytic step 2 spliceosome ZCCHC9 350.258554678126 355.910197329755 344.606912026498 0.968241187276843 -0.0465616296741285 0.8124873823717 1 6.7261 6.8653 7.92622 6.03001 GeneID:84240,Genbank:NM_032280.2,HGNC:HGNC:25424 zinc finger CCHC-type containing 9 GO:0003723,GO:0005730,GO:0006351,GO:0008270,GO:0010923 RNA binding|nucleolus|transcription, DNA-templated|zinc ion binding|negative regulation of phosphatase activity ZCRB1 730.348856980012 673.181189144033 787.516524815992 1.16984333120974 0.226315332867596 0.149418900383136 1 13.9574 12.2108 15.5638 15.0455 GeneID:85437,Genbank:NM_033114.3,HGNC:HGNC:29620,MIM:610750 zinc finger CCHC-type and RNA binding motif containing 1 GO:0000398,GO:0003723,GO:0005654,GO:0005689,GO:0008270,GO:0008380 mRNA splicing, via spliceosome|RNA binding|nucleoplasm|U12-type spliceosomal complex|zinc ion binding|RNA splicing ZCWPW1 137.727338178904 142.185299149972 133.269377207836 0.937293644311769 -0.0934269948955621 0.735459533621719 1 0.89037 0.840664 0.866123 0.826453 GeneID:55063,Genbank:XM_006716038.4,HGNC:HGNC:23486 zinc finger CW-type and PWWP domain containing 1 GO:0008270 zinc ion binding ZCWPW2 5.20417065817065 3.6226049124413 6.7857364039 1.87316490975745 0.905477917208397 0.526567055235529 1 0 0.0190794 0.0377478 0.0234094 GeneID:152098,Genbank:NM_001040432.3,HGNC:HGNC:23574 zinc finger CW-type and PWWP domain containing 2 GO:0008270 zinc ion binding ZDBF2 97.440776619836 100.356742195072 94.5248110446002 0.941887998524945 -0.0863725781271841 0.880618869116758 1 0.332474 0.200279 0.325414 0.177362 GeneID:57683,Genbank:XM_017004575.2,HGNC:HGNC:29313,MIM:617059 zinc finger DBF-type containing 2 GO:0003676,GO:0008270 nucleic acid binding|zinc ion binding ZDHHC1 102.392610483445 93.8133261811023 110.971894785787 1.18290118582472 0.242329562540904 0.419234191987805 1 0.898637 0.804056 1.19352 1.3949 GeneID:29800,Genbank:XM_024450247.1,HGNC:HGNC:17916 zinc finger DHHC-type containing 1 GO:0005783,GO:0016021,GO:0016409,GO:0018345,GO:0019706 endoplasmic reticulum|integral component of membrane|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC11 16.5907206022234 17.1907166880847 15.9907245163621 0.930195337780515 -0.104394385919039 0.90094924130902 1 0.0268868 0.0475694 0.0100448 0.0608387 GeneID:79844,Genbank:XM_017009871.1,HGNC:HGNC:19158 zinc finger DHHC-type containing 11 GO:0005783,GO:0016021,GO:0019706 endoplasmic reticulum|integral component of membrane|protein-cysteine S-palmitoyltransferase activity ZDHHC11B 0.729669017539152 0.490071401957362 0.969266633120943 1.97780696700452 0.983901626635446 1 1 0 0.0032069 0 0 GeneID:653082,Genbank:XM_017010122.1,HGNC:HGNC:32962 zinc finger DHHC-type containing 11B GO:0016021,GO:0019706 integral component of membrane|protein-cysteine S-palmitoyltransferase activity ZDHHC12 795.212670131724 688.56754170516 901.857798558287 1.30975938297198 0.389301797352392 0.0156966580686875 0.521571941137134 18.2835 21.0437 25.4069 27.3398 GeneID:84885,Genbank:XM_011519116.2,HGNC:HGNC:19159 zinc finger DHHC-type containing 12 GO:0005783,GO:0005794,GO:0016021,GO:0016409,GO:0018345,GO:0019706 endoplasmic reticulum|Golgi apparatus|integral component of membrane|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC13 734.147161410952 754.43597231873 713.858350503174 0.946214624826488 -0.0797606353677441 0.635117062654887 1 9.80561 9.36669 9.49552 9.08844 GeneID:54503,Genbank:XM_011520195.1,HGNC:HGNC:18413,MIM:612815 zinc finger DHHC-type containing 13 GO:0000139,GO:0004871,GO:0005783,GO:0015095,GO:0016020,GO:0016021,GO:0016409,GO:0019706,GO:0030659,GO:0030660,GO:0043123 Golgi membrane|signal transducer activity|endoplasmic reticulum|magnesium ion transmembrane transporter activity|membrane|integral component of membrane|palmitoyltransferase activity|protein-cysteine S-palmitoyltransferase activity|cytoplasmic vesicle membrane|Golgi-associated vesicle membrane|positive regulation of I-kappaB kinase/NF-kappaB signaling ZDHHC14 453.400371351854 437.645243251302 469.155499452405 1.07199954000873 0.100304286740401 0.590744927411344 1 1.37906 1.45464 1.83898 1.40077 GeneID:79683,Genbank:NM_024630.2,HGNC:HGNC:20341 zinc finger DHHC-type containing 14 GO:0005783,GO:0016021,GO:0016409,GO:0018345,GO:0019706 endoplasmic reticulum|integral component of membrane|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC15 25.6693607829124 25.6562006903067 25.6825208755181 1.00102588007979 0.00147927345474981 1 1 0.0880709 0.107727 0.0671168 0.108385 GeneID:158866,Genbank:NM_001146256.1,HGNC:HGNC:20342,MIM:300576 zinc finger DHHC-type containing 15 GO:0005794,GO:0016021,GO:0016188,GO:0016409,GO:0018345,GO:0019706,GO:0045184,GO:0070062 Golgi apparatus|integral component of membrane|synaptic vesicle maturation|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|establishment of protein localization|extracellular exosome ZDHHC16 1190.61773181314 907.499911861989 1473.73555176428 1.62395117894888 0.699508261250271 3.12314550860227e-06 0.001923857633299 12.092 12.7566 20.4005 20.6565 GeneID:84287,Genbank:NM_198046.2,HGNC:HGNC:20714,MIM:616750 zinc finger DHHC-type containing 16 GO:0001654,GO:0005789,GO:0006915,GO:0006974,GO:0007507,GO:0016021,GO:0016409,GO:0018345,GO:0019706,GO:0021537 eye development|endoplasmic reticulum membrane|apoptotic process|cellular response to DNA damage stimulus|heart development|integral component of membrane|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|telencephalon development ZDHHC17 144.044757313844 149.468726594431 138.620788033256 0.927423355986634 -0.108700035263777 0.702739135606416 1 1.03338 0.885536 1.08164 0.728697 GeneID:23390,Genbank:NM_015336.3,HGNC:HGNC:18412,MIM:607799 zinc finger DHHC-type containing 17 GO:0000139,GO:0004871,GO:0005794,GO:0015095,GO:0016021,GO:0016235,GO:0016409,GO:0018345,GO:0019706,GO:0030054,GO:0030659,GO:0030660,GO:0042734,GO:0042802,GO:0042953,GO:0043123,GO:0043231 Golgi membrane|signal transducer activity|Golgi apparatus|magnesium ion transmembrane transporter activity|integral component of membrane|aggresome|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|cell junction|cytoplasmic vesicle membrane|Golgi-associated vesicle membrane|presynaptic membrane|identical protein binding|lipoprotein transport|positive regulation of I-kappaB kinase/NF-kappaB signaling|intracellular membrane-bounded organelle ZDHHC18 876.994496330258 663.602309169804 1090.38668349071 1.64313274445177 0.716449036603431 4.95777872517924e-06 0.00294088089120262 9.64339 9.49921 16.2869 16.2228 GeneID:84243,Genbank:NM_032283.2,HGNC:HGNC:20712 zinc finger DHHC-type containing 18 GO:0005794,GO:0016021,GO:0016409,GO:0018345,GO:0019706,GO:0034613 Golgi apparatus|integral component of membrane|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|cellular protein localization ZDHHC19 0.487569852272266 0.490071401957362 0.48506830258717 0.989791080748215 -0.0148040531050533 1 1 0 0 0.0442161 0 GeneID:131540,Genbank:XM_006713494.2,HGNC:HGNC:20713 zinc finger DHHC-type containing 19 GO:0005783,GO:0016021,GO:0019706 endoplasmic reticulum|integral component of membrane|protein-cysteine S-palmitoyltransferase activity ZDHHC2 2152.10168364181 2266.21891940261 2037.984447881 0.899288427270843 -0.153144191765416 0.28462966377227 1 6.88388 6.39853 6.35736 5.23249 GeneID:51201,Genbank:XM_011544549.3,HGNC:HGNC:18469 zinc finger DHHC-type containing 2 GO:0005783,GO:0005794,GO:0005886,GO:0005887,GO:0016409,GO:0018345,GO:0019706,GO:0044267,GO:0055038 endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of plasma membrane|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|cellular protein metabolic process|recycling endosome membrane ZDHHC20 611.185755275563 727.568289105337 494.803221445787 0.680078047456175 -0.556227771735154 0.00101862901668199 0.103795225877033 5.427 4.72604 3.46583 3.29895 GeneID:253832,Genbank:NM_001286638.1,HGNC:HGNC:20749 zinc finger DHHC-type containing 20 GO:0005886,GO:0016020,GO:0016021,GO:0016409,GO:0018345,GO:0019706 plasma membrane|membrane|integral component of membrane|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC21 297.729504911706 337.123787921105 258.335221902307 0.766291881968184 -0.384034072894313 0.0908719318909176 0.980317831934173 1.24965 1.03368 1.00328 0.725569 GeneID:340481,Genbank:NM_001354127.1,HGNC:HGNC:20750,MIM:614605 zinc finger DHHC-type containing 21 GO:0000139,GO:0001942,GO:0005794,GO:0005886,GO:0016021,GO:0016409,GO:0018230,GO:0018345,GO:0019706,GO:0048733,GO:0050999 Golgi membrane|hair follicle development|Golgi apparatus|plasma membrane|integral component of membrane|palmitoyltransferase activity|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|sebaceous gland development|regulation of nitric-oxide synthase activity ZDHHC22 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0.00496707 GeneID:283576,Genbank:XM_011536661.2,HGNC:HGNC:20106 zinc finger DHHC-type containing 22 GO:0005783,GO:0005794,GO:0005886,GO:0016021,GO:0018345,GO:0019706,GO:0072659 endoplasmic reticulum|Golgi apparatus|plasma membrane|integral component of membrane|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|protein localization to plasma membrane ZDHHC23 177.899279031011 199.743150241337 156.055407820685 0.781280397511171 -0.356087677763855 0.145139584686534 1 1.28838 1.04401 0.967667 0.893773 GeneID:254887,Genbank:NM_001320466.1,HGNC:HGNC:28654,MIM:617334 zinc finger DHHC-type containing 23 GO:0016021,GO:0018345,GO:0019706,GO:0072659 integral component of membrane|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|protein localization to plasma membrane ZDHHC24 480.786325446998 478.877867599767 482.69478329423 1.00797054103501 0.0114534752229988 0.972276357991552 1 2.65077 2.92105 2.96918 2.8121 GeneID:254359,Genbank:NM_001348571.1,HGNC:HGNC:27387 zinc finger DHHC-type containing 24 GO:0016021,GO:0019706 integral component of membrane|protein-cysteine S-palmitoyltransferase activity ZDHHC3 2834.77837014507 2995.36836892257 2674.18837136756 0.892774457763757 -0.163632342568704 0.225679367865865 1 5.64241 5.7969 6.0952 5.69317 GeneID:51304,Genbank:NM_001349377.1,HGNC:HGNC:18470,MIM:617150 zinc finger DHHC-type containing 3 GO:0000139,GO:0005794,GO:0006605,GO:0016020,GO:0016021,GO:0016409,GO:0018345,GO:0019706 Golgi membrane|Golgi apparatus|protein targeting|membrane|integral component of membrane|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC4 1862.49351974335 1790.8324375489 1934.1546019378 1.08003102991872 0.111072762450566 0.438225665641264 1 39.4831 40.5817 45.1498 42.5072 GeneID:55146,Genbank:XM_005249796.3,HGNC:HGNC:18471 zinc finger DHHC-type containing 4 GO:0005783,GO:0005789,GO:0005794,GO:0016021,GO:0019706 endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|integral component of membrane|protein-cysteine S-palmitoyltransferase activity ZDHHC5 3953.80480023364 3910.78687545589 3996.82272501139 1.02199962623774 0.0313946686580642 0.833042294101376 1 27.9441 30.4151 31.7089 28.9491 GeneID:25921,Genbank:NM_015457.2,HGNC:HGNC:18472,MIM:614586 zinc finger DHHC-type containing 5 GO:0005737,GO:0005886,GO:0016020,GO:0016021,GO:0016409,GO:0018345,GO:0019706,GO:0030425 cytoplasm|plasma membrane|membrane|integral component of membrane|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|dendrite ZDHHC6 1187.34870359488 1199.4498699079 1175.24753728186 0.979822139104577 -0.0294082051694995 0.873876433006349 1 9.71561 8.76032 9.95748 9.18584 GeneID:64429,Genbank:XM_011540091.2,HGNC:HGNC:19160 zinc finger DHHC-type containing 6 GO:0005783,GO:0005789,GO:0016021,GO:0016409,GO:0018345,GO:0019706 endoplasmic reticulum|endoplasmic reticulum membrane|integral component of membrane|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC7 1632.66750995587 1582.73947316493 1682.59554674681 1.0630906572275 0.0882646308818562 0.555874896181511 1 18.5778 20.72 21.3501 20.9891 GeneID:55625,Genbank:NM_017740.2,HGNC:HGNC:18459,MIM:614604 zinc finger DHHC-type containing 7 GO:0000139,GO:0005794,GO:0016021,GO:0016409,GO:0018230,GO:0018345,GO:0019706 Golgi membrane|Golgi apparatus|integral component of membrane|palmitoyltransferase activity|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity ZDHHC8 650.655242685142 654.772232280318 646.538253089965 0.987424666495588 -0.0182574099193779 0.89080829797945 1 5.93592 6.50013 6.95661 5.80986 GeneID:29801,Genbank:NM_013373.3,HGNC:HGNC:18474,MIM:608784 zinc finger DHHC-type containing 8 GO:0005739,GO:0005794,GO:0005829,GO:0007626,GO:0016021,GO:0016409,GO:0018345,GO:0019706,GO:0030659,GO:0034380,GO:1903146,GO:1903955 mitochondrion|Golgi apparatus|cytosol|locomotory behavior|integral component of membrane|palmitoyltransferase activity|protein palmitoylation|protein-cysteine S-palmitoyltransferase activity|cytoplasmic vesicle membrane|high-density lipoprotein particle assembly|regulation of autophagy of mitochondrion|positive regulation of protein targeting to mitochondrion ZDHHC9 1916.07903068768 1880.9947498531 1951.16331152227 1.03730396465735 0.0528387138674126 0.720535162970909 1 11.3364 12.5074 13.3693 11.9183 GeneID:51114,Genbank:NM_016032.3,HGNC:HGNC:18475,MIM:300646 zinc finger DHHC-type containing 9 GO:0002178,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0016021,GO:0016409,GO:0018230,GO:0018345,GO:0031228,GO:0043849 palmitoyltransferase complex|endoplasmic reticulum|endoplasmic reticulum membrane|Golgi apparatus|cytosol|integral component of membrane|palmitoyltransferase activity|peptidyl-L-cysteine S-palmitoylation|protein palmitoylation|intrinsic component of Golgi membrane|Ras palmitoyltransferase activity ZEB1 126.756841318154 129.433634043972 124.080048592335 0.958638374861526 -0.0609414018381719 0.902871936180376 1 0.636802 0.438489 0.603973 0.431337 GeneID:6935,Genbank:NM_001323643.1,HGNC:HGNC:11642,MIM:189909 zinc finger E-box binding homeobox 1 GO:0000122,GO:0001227,GO:0003682,GO:0003700,GO:0003713,GO:0003714,GO:0005634,GO:0005654,GO:0005667,GO:0005829,GO:0006351,GO:0006357,GO:0006955,GO:0007389,GO:0007417,GO:0008134,GO:0008270,GO:0008283,GO:0008285,GO:0010464,GO:0017015,GO:0019221,GO:0033081,GO:0045602,GO:0045666,GO:0045892,GO:0045944,GO:0048596,GO:0048704,GO:0048752,GO:0051150,GO:0051216,GO:0070888,GO:0071230,GO:0090103 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|nucleus|nucleoplasm|transcription factor complex|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|immune response|pattern specification process|central nervous system development|transcription factor binding|zinc ion binding|cell proliferation|negative regulation of cell proliferation|regulation of mesenchymal cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|cytokine-mediated signaling pathway|regulation of T cell differentiation in thymus|negative regulation of endothelial cell differentiation|positive regulation of neuron differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|embryonic camera-type eye morphogenesis|embryonic skeletal system morphogenesis|semicircular canal morphogenesis|regulation of smooth muscle cell differentiation|cartilage development|E-box binding|cellular response to amino acid stimulus|cochlea morphogenesis hsa05202,hsa05206,hsa05215 Transcriptional misregulation in cancer|MicroRNAs in cancer|Prostate cancer ZEB2 416.213991291816 429.159124938009 403.268857645623 0.939672103450844 -0.0897706755986888 0.77072633640221 1 1.83303 1.43948 1.87998 1.22448 GeneID:9839,Genbank:NM_001171653.1,HGNC:HGNC:14881,MIM:605802 zinc finger E-box binding homeobox 2 GO:0000122,GO:0000790,GO:0001205,GO:0001227,GO:0001755,GO:0001756,GO:0001843,GO:0005634,GO:0005730,GO:0005829,GO:0007399,GO:0019208,GO:0021540,GO:0021766,GO:0021846,GO:0021957,GO:0030177,GO:0043507,GO:0043565,GO:0045636,GO:0045944,GO:0046872,GO:0048023,GO:0048066,GO:0048668,GO:0050772,GO:0061373,GO:0070412,GO:0097324,GO:1902748,GO:1903056 negative regulation of transcription from RNA polymerase II promoter|nuclear chromatin|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|neural crest cell migration|somitogenesis|neural tube closure|nucleus|nucleolus|cytosol|nervous system development|phosphatase regulator activity|corpus callosum morphogenesis|hippocampus development|cell proliferation in forebrain|corticospinal tract morphogenesis|positive regulation of Wnt signaling pathway|positive regulation of JUN kinase activity|sequence-specific DNA binding|positive regulation of melanocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|positive regulation of melanin biosynthetic process|developmental pigmentation|collateral sprouting|positive regulation of axonogenesis|mammillary axonal complex development|R-SMAD binding|melanocyte migration|positive regulation of lens fiber cell differentiation|regulation of melanosome organization hsa05206 MicroRNAs in cancer ZER1 778.083906789173 695.975430663459 860.192382914888 1.23595222620845 0.305622979209771 0.0568095072783387 0.865676297440002 5.44433 5.69401 6.68693 6.77997 GeneID:10444,Genbank:XM_011518122.2,HGNC:HGNC:30960,MIM:617764 zyg-11 related cell cycle regulator GO:0004842,GO:0031462,GO:0051438 ubiquitin-protein transferase activity|Cul2-RING ubiquitin ligase complex|regulation of ubiquitin-protein transferase activity ZFAND1 291.01496556555 301.417236163973 280.612694967127 0.930977599484297 -0.103181639779674 0.610992835787202 1 3.92967 4.54305 4.37258 4.05899 GeneID:79752,Genbank:NM_001170796.1,HGNC:HGNC:25858 zinc finger AN1-type containing 1 GO:0008270 zinc ion binding ZFAND2A 561.444558607355 582.088794312321 540.800322902389 0.929068431116751 -0.106143231759676 0.524097793853878 1 4.60449 5.15737 4.26324 4.93883 GeneID:90637,Genbank:XM_017012774.2,HGNC:HGNC:28073,MIM:610699 zinc finger AN1-type containing 2A GO:0000502,GO:0005634,GO:0005737,GO:0008270,GO:0032436,GO:0071243 proteasome complex|nucleus|cytoplasm|zinc ion binding|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular response to arsenic-containing substance ZFAND2B 640.320189079849 635.64084729462 644.999530865077 1.01472322556093 0.0210862736546465 0.944078972001536 1 18.3438 20.5094 20.069 20.5502 GeneID:130617,Genbank:NM_138802.2,HGNC:HGNC:25206,MIM:613474 zinc finger AN1-type containing 2B GO:0005783,GO:0006616,GO:0008270 endoplasmic reticulum|SRP-dependent cotranslational protein targeting to membrane, translocation|zinc ion binding ZFAND3 3488.51421379644 3182.78329887582 3794.24512871705 1.1921154450123 0.253523953821879 0.0624912769504159 0.89203234548829 35.0861 36.1534 44.8638 40.9454 GeneID:60685,Genbank:NM_021943.2,HGNC:HGNC:18019,MIM:607455 zinc finger AN1-type containing 3 GO:0003677,GO:0008270 DNA binding|zinc ion binding ZFAND4 65.4555424139941 71.7797304032369 59.1313544247513 0.82378902919486 -0.27965318163526 0.441617259504553 1 0.355028 0.371505 0.364738 0.261736 GeneID:93550,Genbank:XM_017016934.1,HGNC:HGNC:23504 zinc finger AN1-type containing 4 GO:0008270 zinc ion binding ZFAND5 2299.68111559409 2540.2313916774 2059.13083951077 0.810607587268282 -0.302924415847173 0.0307791127801716 0.695369080690778 12.2071 11.651 9.67367 9.59588 GeneID:7763,Genbank:NM_006007.3,HGNC:HGNC:13008,MIM:604761 zinc finger AN1-type containing 5 GO:0001701,GO:0001944,GO:0003016,GO:0003677,GO:0005737,GO:0008270,GO:0010761,GO:0048008,GO:0048705,GO:0048745,GO:0060324 in utero embryonic development|vasculature development|respiratory system process|DNA binding|cytoplasm|zinc ion binding|fibroblast migration|platelet-derived growth factor receptor signaling pathway|skeletal system morphogenesis|smooth muscle tissue development|face development ZFAND6 1611.63497039171 1596.9092581987 1626.36068258472 1.01844276638439 0.0263649071830444 0.829873112250036 1 15.1567 14.1039 15.2627 15.3444 GeneID:54469,Genbank:NM_001242912.1,HGNC:HGNC:30164,MIM:610183 zinc finger AN1-type containing 6 GO:0003677,GO:0005737,GO:0006625,GO:0006915,GO:0008270,GO:0031593,GO:0043066,GO:0043122,GO:0071356 DNA binding|cytoplasm|protein targeting to peroxisome|apoptotic process|zinc ion binding|polyubiquitin modification-dependent protein binding|negative regulation of apoptotic process|regulation of I-kappaB kinase/NF-kappaB signaling|cellular response to tumor necrosis factor ZFAT 382.752187689586 365.183336347368 400.321039031804 1.09621934843985 0.132536503812954 0.495602534492316 1 0.51044 0.595584 0.691195 0.607324 GeneID:57623,Genbank:NM_001174157.1,HGNC:HGNC:19899,MIM:610931 zinc finger and AT-hook domain containing GO:0001077,GO:0002244,GO:0003677,GO:0005634,GO:0005829,GO:0046872,GO:0060712 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|hematopoietic progenitor cell differentiation|DNA binding|nucleus|cytosol|metal ion binding|spongiotrophoblast layer development ZFC3H1 134.875827768607 140.321066091512 129.430589445702 0.922388868976323 -0.116552991665189 0.789938693004267 1 0.621334 0.600321 0.798119 0.408952 GeneID:196441,Genbank:NM_144982.4,HGNC:HGNC:28328 zinc finger C3H1-type containing GO:0000178,GO:0003723,GO:0005615,GO:0005634,GO:0006396,GO:0046872 exosome (RNase complex)|RNA binding|extracellular space|nucleus|RNA processing|metal ion binding ZFHX2 90.8945003411172 84.3676993749655 97.4213013072688 1.15472274376344 0.207546493014048 0.522651011854825 1 0.162273 0.184944 0.219181 0.144073 GeneID:85446,Genbank:NM_033400.2,HGNC:HGNC:20152,MIM:617828 zinc finger homeobox 2 GO:0005634,GO:0006351,GO:0006355,GO:0008270,GO:0030534,GO:0043565 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|adult behavior|sequence-specific DNA binding ZFHX3 302.09188975698 265.825337265572 338.358442248389 1.27286001300302 0.348073762796652 0.451986739027657 1 0.605859 0.633301 1.06141 0.557886 GeneID:463,Genbank:NM_001164766.1,HGNC:HGNC:777,MIM:104155 zinc finger homeobox 3 hsa04550 Signaling pathways regulating pluripotency of stem cells ZFHX4 628.944700403957 657.788078930362 600.101321877553 0.912301911663382 -0.132416754730092 0.694416080140285 1 1.62778 1.52659 1.87724 1.09608 GeneID:79776,Genbank:XM_011517597.2,HGNC:HGNC:30939,MIM:606940 zinc finger homeobox 4 GO:0005634,GO:0006351,GO:0006355,GO:0008270,GO:0043565 nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|sequence-specific DNA binding ZFP1 80.4576540450525 73.6821810812735 87.2331270088315 1.18391076008745 0.243560338710593 0.452343991812843 1 0.588323 0.569486 0.717344 0.660742 GeneID:162239,Genbank:XM_011522921.2,HGNC:HGNC:23328,MIM:617230 ZFP1 zinc finger protein GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZFP14 38.4404799525955 40.050567790702 36.830392114489 0.919597252826948 -0.120925938682138 0.820762452846578 1 0.17245 0.148915 0.1263 0.159483 GeneID:57677,Genbank:NM_020917.2,HGNC:HGNC:29312 ZFP14 zinc finger protein GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZFP28 143.287160284722 148.930628917789 137.643691651654 0.924213458654197 -0.113701996302314 0.688414295803369 1 0.589602 0.497322 0.588364 0.479555 GeneID:140612,Genbank:XM_011526463.3,HGNC:HGNC:17801,MIM:616798 ZFP28 zinc finger protein GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZFP3 130.201820608862 117.441597678679 142.962043539045 1.21730329257092 0.283688662032206 0.271288643488588 1 1.06202 0.753196 1.11671 1.12832 GeneID:124961,Genbank:NM_153018.2,HGNC:HGNC:12861,MIM:194480 ZFP3 zinc finger protein GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZFP30 122.971740729557 137.37082902466 108.572652434453 0.790361776261561 -0.339414918373861 0.286807268187803 1 0.855267 0.695515 0.733678 0.517534 GeneID:22835,Genbank:NM_001320668.2,HGNC:HGNC:29555,MIM:617317 ZFP30 zinc finger protein GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZFP36 171.077062265308 166.237015465459 175.917109065157 1.05823067487463 0.0816541427861665 0.758475375096116 1 4.46818 4.75883 4.87421 4.87997 GeneID:7538,Genbank:NM_003407.3,HGNC:HGNC:12862,MIM:190700 ZFP36 ring finger protein hsa05166,hsa05167 Human T-cell leukemia virus 1 infection|Kaposi sarcoma-associated herpesvirus infection ZFP36L1 2762.73814801985 2767.34413919091 2758.1321568488 0.996671182954207 -0.00481047889555955 0.968116866474041 1 31.6904 31.8028 34.0756 29.8146 GeneID:677,Genbank:NM_001244701.1,HGNC:HGNC:1107,MIM:601064 ZFP36 ring finger protein like 1 hsa04218 Cellular senescence ZFP36L2 641.128622175861 701.154493676034 581.102750675687 0.828779899318713 -0.270939081612981 0.0993852173180052 1 11.4422 11.5738 10.6869 8.94103 GeneID:678,Genbank:NM_006887.4,HGNC:HGNC:1108,MIM:612053 ZFP36 ring finger protein like 2 GO:0000288,GO:0003677,GO:0003700,GO:0003723,GO:0005634,GO:0005737,GO:0005829,GO:0006402,GO:0008283,GO:0009611,GO:0017091,GO:0030097,GO:0030529,GO:0033077,GO:0035019,GO:0035925,GO:0043488,GO:0044344,GO:0045577,GO:0045599,GO:0046872,GO:0048103,GO:0060216,GO:0061158,GO:0070371,GO:0071356,GO:0071364,GO:0071385,GO:0071560,GO:0097011,GO:1900153,GO:1901991,GO:1904628,GO:2000737 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|DNA binding|DNA binding transcription factor activity|RNA binding|nucleus|cytoplasm|cytosol|mRNA catabolic process|cell proliferation|response to wounding|AU-rich element binding|hemopoiesis|intracellular ribonucleoprotein complex|T cell differentiation in thymus|somatic stem cell population maintenance|mRNA 3'-UTR AU-rich region binding|regulation of mRNA stability|cellular response to fibroblast growth factor stimulus|regulation of B cell differentiation|negative regulation of fat cell differentiation|metal ion binding|somatic stem cell division|definitive hemopoiesis|3'-UTR-mediated mRNA destabilization|ERK1 and ERK2 cascade|cellular response to tumor necrosis factor|cellular response to epidermal growth factor stimulus|cellular response to glucocorticoid stimulus|cellular response to transforming growth factor beta stimulus|cellular response to granulocyte macrophage colony-stimulating factor stimulus|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of mitotic cell cycle phase transition|cellular response to phorbol 13-acetate 12-myristate|negative regulation of stem cell differentiation hsa04218 Cellular senescence ZFP37 13.8411148319926 15.0765436010925 12.6056860628926 0.836112466917101 -0.258231080152441 0.807412339660778 1 0.196452 0.130913 0.202195 0.0659531 GeneID:7539,Genbank:NM_003408.2,HGNC:HGNC:12863,MIM:602951 ZFP37 zinc finger protein GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0008270 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding ZFP41 240.879245396867 220.047800130544 261.710690663189 1.18933563756569 0.250155909633507 0.251351289391461 1 1.33375 1.38667 1.82695 1.5955 GeneID:286128,Genbank:NM_001271156.2,HGNC:HGNC:26786 ZFP41 zinc finger protein GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0007275,GO:0007283,GO:0030154,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|spermatogenesis|cell differentiation|metal ion binding ZFP62 183.457635292572 158.52033454798 208.394936037163 1.31462589093948 0.394652303642961 0.0860269041200173 0.964561165794104 0.713328 0.549953 0.916403 0.803287 GeneID:643836,Genbank:XM_017009716.2,HGNC:HGNC:23241,MIM:610281 ZFP62 zinc finger protein GO:0003676,GO:0005634,GO:0006351,GO:0006355,GO:0046872 nucleic acid binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZFP64 402.541248531346 410.134618157644 394.947878905049 0.962971330435809 -0.0544352480686616 0.754807683381705 1 2.31573 2.73094 2.35961 2.50272 GeneID:55734,Genbank:NM_199427.2,HGNC:HGNC:15940 ZFP64 zinc finger protein GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZFP69 0.487134866245567 0.490071401957362 0.484198330533773 0.988015886256305 -0.0173938558720137 1 1 0 0.0114561 0 0.0108037 GeneID:339559,Genbank:XM_005270809.4,HGNC:HGNC:24708 ZFP69 zinc finger protein GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZFP69B 63.1440539906006 65.7067684810088 60.5813395001924 0.921995418443113 -0.117168513219542 0.768162927909619 1 0.479603 0.466241 0.483932 0.394968 GeneID:65243,Genbank:XM_005271139.3,HGNC:HGNC:28053 ZFP69 zinc finger protein B GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZFP82 21.765647175946 20.2654152687757 23.2658790831162 1.14805834346575 0.199195960558807 0.751910290211067 1 0.120611 0.0687475 0.142804 0.0932967 GeneID:284406,Genbank:NM_001321919.1,HGNC:HGNC:28682 ZFP82 zinc finger protein GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZFP90 327.625679418271 288.377413409864 366.873945426677 1.27220069383606 0.347326278454719 0.0723268263102106 0.929024313086611 1.7934 1.68769 2.24814 1.95774 GeneID:146198,Genbank:XM_024450159.1,HGNC:HGNC:23329,MIM:609451 ZFP90 zinc finger protein GO:0001078,GO:0003677,GO:0005634,GO:0006351,GO:0043392,GO:0045893,GO:0046872 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|negative regulation of DNA binding|positive regulation of transcription, DNA-templated|metal ion binding ZFP91 3879.30770324331 3810.59753604507 3948.01787044156 1.03606267339876 0.0511112770271003 0.693097979446279 1 25.7987 25.4422 29.1298 24.4075 GeneID:80829,Genbank:NM_053023.4,HGNC:HGNC:14983 ZFP91 zinc finger protein GO:0003676,GO:0004842,GO:0005634,GO:0005730,GO:0007250,GO:0046872,GO:0070534 nucleic acid binding|ubiquitin-protein transferase activity|nucleus|nucleolus|activation of NF-kappaB-inducing kinase activity|metal ion binding|protein K63-linked ubiquitination ZFP92 0.753247168854925 0.538097676642304 0.968396661067546 1.7996670550787 0.847730027434814 1 1 0.00676807 0 0 0.0118814 GeneID:139735,Genbank:XM_017029281.1,HGNC:HGNC:12865 ZFP92 zinc finger protein GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZFPL1 616.090355414906 588.161756234549 644.018954595262 1.0949691097196 0.130890170389963 0.444483956543485 1 17.0649 17.3524 18.3734 20.726 GeneID:7542,Genbank:NM_006782.3,HGNC:HGNC:12868 zinc finger protein like 1 GO:0003677,GO:0005634,GO:0005794,GO:0006355,GO:0008270,GO:0016021,GO:0016192 DNA binding|nucleus|Golgi apparatus|regulation of transcription, DNA-templated|zinc ion binding|integral component of membrane|vesicle-mediated transport ZFPM1 153.077432680561 147.68194577598 158.472919585141 1.07306901160098 0.101742862201492 0.712465528111696 1 0.81922 0.937746 0.994655 0.933682 GeneID:161882,Genbank:XM_011522914.2,HGNC:HGNC:19762,MIM:601950 zinc finger protein, FOG family member 1 GO:0000978,GO:0001078,GO:0001085,GO:0001102,GO:0002295,GO:0003151,GO:0003181,GO:0003192,GO:0003195,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006351,GO:0007507,GO:0007596,GO:0008134,GO:0010724,GO:0017053,GO:0030218,GO:0030219,GO:0030220,GO:0030851,GO:0032091,GO:0032642,GO:0035162,GO:0035855,GO:0045078,GO:0045403,GO:0045599,GO:0045652,GO:0046872,GO:0055008,GO:0060318,GO:0060319,GO:0060377,GO:0060412,GO:0060413,GO:0071733 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|RNA polymerase II activating transcription factor binding|T-helper cell lineage commitment|outflow tract morphogenesis|atrioventricular valve morphogenesis|mitral valve formation|tricuspid valve formation|nucleus|nucleoplasm|transcription factor complex|cytoplasm|transcription, DNA-templated|heart development|blood coagulation|transcription factor binding|regulation of definitive erythrocyte differentiation|transcriptional repressor complex|erythrocyte differentiation|megakaryocyte differentiation|platelet formation|granulocyte differentiation|negative regulation of protein binding|regulation of chemokine production|embryonic hemopoiesis|megakaryocyte development|positive regulation of interferon-gamma biosynthetic process|negative regulation of interleukin-4 biosynthetic process|negative regulation of fat cell differentiation|regulation of megakaryocyte differentiation|metal ion binding|cardiac muscle tissue morphogenesis|definitive erythrocyte differentiation|primitive erythrocyte differentiation|negative regulation of mast cell differentiation|ventricular septum morphogenesis|atrial septum morphogenesis|transcriptional activation by promoter-enhancer looping ZFPM2 2.18987702467085 1.47021420587209 2.90953984346962 1.97899042999913 0.984764635818378 0.767757144762217 1 0 0.0112631 0.0112664 0.00350157 GeneID:23414,Genbank:XM_011516948.2,HGNC:HGNC:16700,MIM:603693 zinc finger protein, FOG family member 2 GO:0001078,GO:0001085,GO:0001105,GO:0001570,GO:0001701,GO:0003148,GO:0003221,GO:0003677,GO:0003714,GO:0005634,GO:0005654,GO:0005737,GO:0007506,GO:0007596,GO:0008134,GO:0008270,GO:0030324,GO:0045599,GO:0045892,GO:0045944,GO:0048568,GO:0060045,GO:0060412,GO:0060548,GO:2000020,GO:2000195 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II transcription factor binding|RNA polymerase II transcription coactivator activity|vasculogenesis|in utero embryonic development|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|DNA binding|transcription corepressor activity|nucleus|nucleoplasm|cytoplasm|gonadal mesoderm development|blood coagulation|transcription factor binding|zinc ion binding|lung development|negative regulation of fat cell differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|embryonic organ development|positive regulation of cardiac muscle cell proliferation|ventricular septum morphogenesis|negative regulation of cell death|positive regulation of male gonad development|negative regulation of female gonad development hsa05206 MicroRNAs in cancer ZFR 2196.32191349986 2214.14790628215 2178.49592071756 0.983898101177691 -0.0234191863736099 0.884273672490172 1 17.1067 16.061 17.5094 15.2742 GeneID:51663,Genbank:NM_016107.4,HGNC:HGNC:17277,MIM:615635 zinc finger RNA binding protein GO:0003677,GO:0003723,GO:0005634,GO:0005694,GO:0005737,GO:0007275,GO:0008270 DNA binding|RNA binding|nucleus|chromosome|cytoplasm|multicellular organism development|zinc ion binding ZFX 192.73109581282 216.789788105367 168.672403520272 0.778045889496843 -0.362072846363429 0.123224667553528 1 0.801499 0.713104 0.69217 0.483365 GeneID:7543,Genbank:NM_001330327.1,HGNC:HGNC:12869,MIM:314980 zinc finger protein, X-linked GO:0003677,GO:0003713,GO:0005654,GO:0005730,GO:0006351,GO:0006355,GO:0007275,GO:0046872 DNA binding|transcription coactivator activity|nucleoplasm|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|metal ion binding ZFYVE1 594.7957818855 547.947492309576 641.644071461423 1.17099554330821 0.227735585096703 0.177241093110083 1 3.68388 3.84527 4.51006 4.31735 GeneID:53349,Genbank:NM_001281734.1,HGNC:HGNC:13180,MIM:605471 zinc finger FYVE-type containing 1 GO:0000407,GO:0005545,GO:0005547,GO:0005776,GO:0005783,GO:0005795,GO:0008270,GO:0009267,GO:0010923,GO:0016236,GO:0043325,GO:0044233,GO:0048471,GO:0097629,GO:1990462 phagophore assembly site|1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|autophagosome|endoplasmic reticulum|Golgi stack|zinc ion binding|cellular response to starvation|negative regulation of phosphatase activity|macroautophagy|phosphatidylinositol-3,4-bisphosphate binding|ER-mitochondrion membrane contact site|perinuclear region of cytoplasm|extrinsic component of omegasome membrane|omegasome hsa04140 Autophagy - animal ZFYVE16 194.653642338909 189.595729624287 199.711555053531 1.05335471136027 0.0749913377386308 0.853559525494474 1 0.520736 0.344272 0.575327 0.343862 GeneID:9765,Genbank:XM_005248632.4,HGNC:HGNC:20756,MIM:608880 zinc finger FYVE-type containing 16 GO:0005545,GO:0005547,GO:0005769,GO:0005829,GO:0006622,GO:0007165,GO:0008565,GO:0016050,GO:0016197,GO:0030100,GO:0030509,GO:0031901,GO:0043231,GO:0046872 1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|early endosome|cytosol|protein targeting to lysosome|signal transduction|protein transporter activity|vesicle organization|endosomal transport|regulation of endocytosis|BMP signaling pathway|early endosome membrane|intracellular membrane-bounded organelle|metal ion binding hsa04144,hsa04350 Endocytosis|TGF-beta signaling pathway ZFYVE19 913.00523257234 904.790823169416 921.219641975264 1.01815758779283 0.0259608752956399 0.899897825483361 1 8.42777 8.59812 8.06283 9.73139 GeneID:84936,Genbank:NM_001077268.1,HGNC:HGNC:20758 zinc finger FYVE-type containing 19 GO:0005737,GO:0005813,GO:0009838,GO:0030496,GO:0032154,GO:0032266,GO:0032466,GO:0044878,GO:0046872,GO:0051301,GO:0090543 cytoplasm|centrosome|abscission|midbody|cleavage furrow|phosphatidylinositol-3-phosphate binding|negative regulation of cytokinesis|mitotic cytokinesis checkpoint|metal ion binding|cell division|Flemming body ZFYVE21 472.473417413016 413.80524934477 531.141585481262 1.28355448927312 0.360144542298596 0.0441195127235997 0.784836632957795 11.0966 12.8284 16.3967 16.0854 GeneID:79038,Genbank:NM_001198953.1,HGNC:HGNC:20760,MIM:613504 zinc finger FYVE-type containing 21 GO:0000285,GO:0005829,GO:0005925,GO:0010008,GO:0042147,GO:0046854,GO:0046872 1-phosphatidylinositol-3-phosphate 5-kinase activity|cytosol|focal adhesion|endosome membrane|retrograde transport, endosome to Golgi|phosphatidylinositol phosphorylation|metal ion binding ZFYVE26 767.377564236467 666.686816405603 868.068312067331 1.30206311375327 0.380799380678682 0.0497475495962744 0.815166074133459 1.73124 1.82768 2.71051 2.02726 GeneID:23503,Genbank:XM_017021125.1,HGNC:HGNC:20761,MIM:612012 zinc finger FYVE-type containing 26 GO:0000724,GO:0000910,GO:0005765,GO:0005813,GO:0030496,GO:0032266,GO:0046872 double-strand break repair via homologous recombination|cytokinesis|lysosomal membrane|centrosome|midbody|phosphatidylinositol-3-phosphate binding|metal ion binding ZFYVE27 1239.12968159044 1223.60068977532 1254.65867340556 1.02538245024686 0.0361621108656947 0.834215461076188 1 6.89355 7.67405 7.33642 7.39642 GeneID:118813,Genbank:NM_144588.6,HGNC:HGNC:26559,MIM:610243 zinc finger FYVE-type containing 27 GO:0005654,GO:0005783,GO:0005829,GO:0016192,GO:0030176,GO:0030424,GO:0030425,GO:0031175,GO:0032584,GO:0043621,GO:0045773,GO:0046872,GO:0048011,GO:0055038,GO:0071782,GO:0071787,GO:0072659 nucleoplasm|endoplasmic reticulum|cytosol|vesicle-mediated transport|integral component of endoplasmic reticulum membrane|axon|dendrite|neuron projection development|growth cone membrane|protein self-association|positive regulation of axon extension|metal ion binding|neurotrophin TRK receptor signaling pathway|recycling endosome membrane|endoplasmic reticulum tubular network|endoplasmic reticulum tubular network formation|protein localization to plasma membrane hsa04144 Endocytosis ZFYVE28 127.249646609245 118.31689627897 136.182396939519 1.15099703611583 0.202884118451466 0.533965105200306 1 0.212933 0.289382 0.360168 0.311655 GeneID:57732,Genbank:XM_006713902.3,HGNC:HGNC:29334,MIM:614176 zinc finger FYVE-type containing 28 GO:0005829,GO:0007175,GO:0031901,GO:0032266,GO:0042059,GO:0046872 cytosol|negative regulation of epidermal growth factor-activated receptor activity|early endosome membrane|phosphatidylinositol-3-phosphate binding|negative regulation of epidermal growth factor receptor signaling pathway|metal ion binding ZFYVE9 464.084566664354 493.406504869109 434.7626284596 0.881144906216698 -0.182548801860328 0.300232486007827 1 2.04862 2.23574 2.18107 1.56681 GeneID:9372,Genbank:XM_017002845.1,HGNC:HGNC:6775,MIM:603755 zinc finger FYVE-type containing 9 GO:0005545,GO:0005769,GO:0005829,GO:0006897,GO:0007179,GO:0007183,GO:0007184,GO:0008236,GO:0019904,GO:0031901,GO:0043231,GO:0043234,GO:0046872 1-phosphatidylinositol binding|early endosome|cytosol|endocytosis|transforming growth factor beta receptor signaling pathway|SMAD protein complex assembly|SMAD protein import into nucleus|serine-type peptidase activity|protein domain specific binding|early endosome membrane|intracellular membrane-bounded organelle|protein complex|metal ion binding hsa04144,hsa04350 Endocytosis|TGF-beta signaling pathway ZG16B 1.26439517244296 1.07619535328461 1.45259499160132 1.34975029130902 0.43269252815597 1 1 0.123815 0 0 0.159652 GeneID:124220,Genbank:NM_145252.2,HGNC:HGNC:30456 zymogen granule protein 16B GO:0001895,GO:0005615,GO:0030246,GO:0070062 retina homeostasis|extracellular space|carbohydrate binding|extracellular exosome ZGLP1 19.7060698844632 20.5153552973084 18.8967844716181 0.921104421432923 -0.118563377502389 0.893011577419261 1 0.308813 0.310438 0.184621 0.26888 GeneID:100125288,Genbank:NM_001103167.1,HGNC:HGNC:37245,MIM:611639 zinc finger, GATA-like protein 1 GO:0000122,GO:0000977,GO:0001085,GO:0001228,GO:0003682,GO:0005634,GO:0005667,GO:0007275,GO:0007283,GO:0008270,GO:0030154,GO:0048599 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription factor binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|chromatin binding|nucleus|transcription factor complex|multicellular organism development|spermatogenesis|zinc ion binding|cell differentiation|oocyte development ZGPAT 523.550556895684 516.450686417068 530.650427374301 1.02749486317028 0.0391311813548512 0.932624107736645 1 9.88478 13.7298 12.8875 13.6346 GeneID:84619,Genbank:NM_001083113.1,HGNC:HGNC:15948 zinc finger CCCH-type and G-patch domain containing GO:0000122,GO:0000978,GO:0001078,GO:0003700,GO:0005634,GO:0005886,GO:0006351,GO:0007175,GO:0043565,GO:0045892,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|plasma membrane|transcription, DNA-templated|negative regulation of epidermal growth factor-activated receptor activity|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding ZGRF1 55.1370041226779 48.2278941448144 62.0461141005413 1.28651924784928 0.363473041657002 0.362427119796797 1 0.19316 0.173682 0.315371 0.187866 GeneID:55345,Genbank:NM_001350397.1,HGNC:HGNC:25654 zinc finger GRF-type containing 1 GO:0008270,GO:0016021 zinc ion binding|integral component of membrane ZHX1 182.322802540002 166.399694598875 198.245910481128 1.19138386016286 0.252638319943044 0.452746338958843 1 1.40225 1.06157 1.77699 1.16734 GeneID:11244,Genbank:NM_007222.4,HGNC:HGNC:12871,MIM:604764 zinc fingers and homeoboxes 1 GO:0000122,GO:0003677,GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0006351,GO:0030154,GO:0045892,GO:0046872,GO:0046982 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|transcription, DNA-templated|cell differentiation|negative regulation of transcription, DNA-templated|metal ion binding|protein heterodimerization activity ZHX1-C8orf76 6.36284660824975 7.8793600508948 4.84633316560471 0.615066849883875 -0.701184873452317 0.613472611691393 1 1.49892 0.920142 1.32196 0.885565 GeneID:100533106,Genbank:NM_001204180.1,HGNC:HGNC:42975 ZHX1-C8orf76 readthrough ZHX2 443.307324409163 459.659221718952 426.955427099375 0.928852086340666 -0.106479219800132 0.557441894186081 1 2.84424 2.72095 2.68174 2.5902 GeneID:22882,Genbank:XM_005250837.4,HGNC:HGNC:18513,MIM:609185 zinc fingers and homeoboxes 2 GO:0000122,GO:0003677,GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006351,GO:0006402,GO:0035019,GO:0042802,GO:0042803,GO:0045665,GO:0045892,GO:0046872,GO:0046982 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|cytosol|plasma membrane|transcription, DNA-templated|mRNA catabolic process|somatic stem cell population maintenance|identical protein binding|protein homodimerization activity|negative regulation of neuron differentiation|negative regulation of transcription, DNA-templated|metal ion binding|protein heterodimerization activity ZHX3 1157.66743391937 1110.52948309297 1204.80538474576 1.08489274988919 0.117552428060687 0.435667387198591 1 2.83501 2.96414 3.3286 3.0213 GeneID:23051,Genbank:NM_015035.3,HGNC:HGNC:15935,MIM:609598 zinc fingers and homeoboxes 3 GO:0000122,GO:0000977,GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0006351,GO:0030154,GO:0042803,GO:0045669,GO:0045892,GO:0046872,GO:0046982 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|transcription, DNA-templated|cell differentiation|protein homodimerization activity|positive regulation of osteoblast differentiation|negative regulation of transcription, DNA-templated|metal ion binding|protein heterodimerization activity ZIC1 188.346876018741 172.646161310482 204.047590727 1.18188316020561 0.241087419167123 0.307586236113934 1 1.59294 1.68908 2.22867 1.77342 GeneID:7545,Genbank:NM_003412.3,HGNC:HGNC:12872,MIM:600470 Zic family member 1 GO:0000978,GO:0001077,GO:0003700,GO:0005634,GO:0005737,GO:0007389,GO:0007420,GO:0007628,GO:0008589,GO:0021510,GO:0030154,GO:0042307,GO:0042472,GO:0045893,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|pattern specification process|brain development|adult walking behavior|regulation of smoothened signaling pathway|spinal cord development|cell differentiation|positive regulation of protein import into nucleus|inner ear morphogenesis|positive regulation of transcription, DNA-templated|metal ion binding ZIC2 96.5938586987527 97.7240887416532 95.4636286558522 0.976868957133211 -0.0337630511931418 0.940221737831618 1 2.03828 1.77211 1.82286 2.13047 GeneID:7546,Genbank:NM_007129.4,HGNC:HGNC:12873,MIM:603073 Zic family member 2 GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0006351,GO:0007420,GO:0007601,GO:0016604,GO:0030154,GO:0031490,GO:0045892,GO:0045893,GO:0046872,GO:0051091 DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|transcription, DNA-templated|brain development|visual perception|nuclear body|cell differentiation|chromatin DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|positive regulation of DNA binding transcription factor activity ZIC3 33.3183419989979 33.6894482203643 32.9472357776315 0.977968993796575 -0.032139369183294 0.970455627863937 1 0.320542 0.404497 0.281763 0.420113 GeneID:7547,Genbank:NM_001330661.1,HGNC:HGNC:12874,MIM:300265 Zic family member 3 GO:0000978,GO:0001077,GO:0001947,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0007368,GO:0009952,GO:0030154,GO:0030324,GO:0035019,GO:0035469,GO:0035545,GO:0043565,GO:0045893,GO:0045944,GO:0046872,GO:0071907,GO:0071910 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|heart looping|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|determination of left/right symmetry|anterior/posterior pattern specification|cell differentiation|lung development|somatic stem cell population maintenance|determination of pancreatic left/right asymmetry|determination of left/right asymmetry in nervous system|sequence-specific DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|determination of digestive tract left/right asymmetry|determination of liver left/right asymmetry hsa04550 Signaling pathways regulating pluripotency of stem cells ZIC4 11.5131179203119 10.4257696100515 12.6004662305723 1.20858859363477 0.273323231409526 0.770254512337784 1 0.0601095 0.0236472 0.0649169 0.0454118 GeneID:84107,Genbank:NM_001243256.1,HGNC:HGNC:20393,MIM:608948 Zic family member 4 GO:0003677,GO:0005634,GO:0046872 DNA binding|nucleus|metal ion binding ZIC5 36.4273102643609 44.749368056428 28.1052524722938 0.628059203804927 -0.671027534162297 0.159124194164998 1 0.49259 0.431347 0.270956 0.283265 GeneID:85416,Genbank:NM_033132.4,HGNC:HGNC:20322,MIM:617896 Zic family member 5 GO:0003677,GO:0005634,GO:0007399,GO:0030154,GO:0046872 DNA binding|nucleus|nervous system development|cell differentiation|metal ion binding ZIK1 411.593182211088 345.81080298739 477.375561434785 1.38045300294506 0.465141772697991 0.0106779422372114 0.413666579021508 2.50937 2.32924 3.58274 3.18121 GeneID:284307,Genbank:XM_011526762.1,HGNC:HGNC:33104 zinc finger protein interacting with K protein 1 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZKSCAN1 937.123664840805 882.071999888289 992.175329793321 1.12482351771621 0.169698663585907 0.513113681548224 1 3.11291 2.60029 3.89018 2.7057 GeneID:7586,Genbank:NM_001346579.1,HGNC:HGNC:13101,MIM:601260 zinc finger with KRAB and SCAN domains 1 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZKSCAN2 184.20979513122 187.164989924716 181.254600337723 0.968421500252956 -0.0462929854348678 0.880722514255908 1 0.982216 0.810716 0.904226 0.825079 GeneID:342357,Genbank:NM_001012981.4,HGNC:HGNC:25677 zinc finger with KRAB and SCAN domains 2 GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZKSCAN3 252.097863370776 252.161172940559 252.034553800994 0.999497864250516 -0.000724610697329889 1 1 1.68909 1.69187 2.08553 1.59047 GeneID:80317,Genbank:XM_006715215.2,HGNC:HGNC:13853,MIM:612791 zinc finger with KRAB and SCAN domains 3 GO:0000122,GO:0000978,GO:0001078,GO:0003677,GO:0003682,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0006914,GO:0007040,GO:0010507,GO:0043565,GO:0045892,GO:0045893,GO:0046872,GO:2000773 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|chromatin binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|autophagy|lysosome organization|negative regulation of autophagy|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|negative regulation of cellular senescence ZKSCAN4 141.091744611428 141.16693872648 141.016550496376 0.998934678109052 -0.00153775385595655 0.998026983121696 1 0.769889 0.941635 0.811532 0.854454 GeneID:387032,Genbank:XM_005249097.4,HGNC:HGNC:13854,MIM:611643 zinc finger with KRAB and SCAN domains 4 GO:0003677,GO:0003700,GO:0005654,GO:0005829,GO:0006351,GO:0042802,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleoplasm|cytosol|transcription, DNA-templated|identical protein binding|metal ion binding ZKSCAN5 706.120089796937 616.411375757843 795.828803836032 1.29106767839514 0.36856462940254 0.0218649294079329 0.600929980812952 3.71332 3.37912 5.42194 4.28649 GeneID:23660,Genbank:NM_001318082.1,HGNC:HGNC:12867,MIM:611272 zinc finger with KRAB and SCAN domains 5 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0008270 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding ZKSCAN7 7.25757227965819 7.24520982488261 7.26993473443377 1.0034125870953 0.0049149409087634 1 1 0.0779006 0.0544562 0.0649584 0.0519577 GeneID:55888,Genbank:NM_025169.2,HGNC:HGNC:12955 zinc finger with KRAB and SCAN domains 7 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZKSCAN8 631.730057448511 683.318801105975 580.141313791047 0.849005343994733 -0.236154460154471 0.164380921385277 1 3.40265 3.054 3.06679 2.53306 GeneID:7745,Genbank:XM_017011266.2,HGNC:HGNC:12983,MIM:602240 zinc finger with KRAB and SCAN domains 8 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZMAT1 7.88498905685227 6.07296192222811 9.69701619147641 1.59675234517503 0.67514056942159 0.564659196055743 1 0.01825 0.04721 0.0822047 0.0164249 GeneID:84460,Genbank:XM_005262214.4,HGNC:HGNC:29377,MIM:301007 zinc finger matrin-type 1 GO:0002039,GO:0003677,GO:0003723,GO:0005634,GO:0008270,GO:0072332 p53 binding|DNA binding|RNA binding|nucleus|zinc ion binding|intrinsic apoptotic signaling pathway by p53 class mediator ZMAT2 2446.86113813269 2391.70357326646 2502.01870299893 1.04612408116354 0.0650539803253824 0.619775592576842 1 51.8533 49.13 51.4581 54.6559 GeneID:153527,Genbank:NM_144723.2,HGNC:HGNC:26433 zinc finger matrin-type 2 GO:0000398,GO:0003677,GO:0003723,GO:0008270,GO:0046540 mRNA splicing, via spliceosome|DNA binding|RNA binding|zinc ion binding|U4/U6 x U5 tri-snRNP complex hsa03040 Spliceosome ZMAT3 481.974896291608 503.495073555511 460.454719027705 0.914516830872109 -0.128918373144884 0.566720304265426 1 2.9148 2.67195 3.03546 2.12988 GeneID:64393,Genbank:XM_005247706.3,HGNC:HGNC:29983,MIM:606452 zinc finger matrin-type 3 GO:0002039,GO:0003723,GO:0005654,GO:0005730,GO:0005886,GO:0006974,GO:0008270,GO:0015031,GO:0040008,GO:0043065,GO:0072332 p53 binding|RNA binding|nucleoplasm|nucleolus|plasma membrane|cellular response to DNA damage stimulus|zinc ion binding|protein transport|regulation of growth|positive regulation of apoptotic process|intrinsic apoptotic signaling pathway by p53 class mediator hsa04115 p53 signaling pathway ZMAT4 9.78040368749911 12.2900026685111 7.27080470648717 0.591603183709319 -0.757298278573966 0.432755525549027 1 0.0310862 0.0401585 0.0300385 0.0186576 GeneID:79698,Genbank:XM_024447276.1,HGNC:HGNC:25844 zinc finger matrin-type 4 GO:0002039,GO:0003677,GO:0003723,GO:0005634,GO:0008270,GO:0072332 p53 binding|DNA binding|RNA binding|nucleus|zinc ion binding|intrinsic apoptotic signaling pathway by p53 class mediator ZMAT5 350.991997565352 350.202845295646 351.781149835058 1.0045068295721 0.00648737288783547 1 1 10.6088 11.092 10.1709 13.8484 GeneID:55954,Genbank:NM_001318129.1,HGNC:HGNC:28046 zinc finger matrin-type 5 GO:0000398,GO:0005654,GO:0005689,GO:0008270,GO:0008380 mRNA splicing, via spliceosome|nucleoplasm|U12-type spliceosomal complex|zinc ion binding|RNA splicing ZMIZ1 1395.6808518321 1505.15532117736 1286.20638248685 0.854533990206909 -0.226790216762813 0.116344259700701 1 5.89889 6.08996 5.39256 5.10482 GeneID:57178,Genbank:XM_005269988.3,HGNC:HGNC:16493,MIM:607159 zinc finger MIZ-type containing 1 GO:0001570,GO:0001701,GO:0003007,GO:0005654,GO:0005737,GO:0006351,GO:0007296,GO:0007569,GO:0008270,GO:0016607,GO:0043231,GO:0045582,GO:0045747,GO:0045944,GO:0048146,GO:0048589,GO:0048844 vasculogenesis|in utero embryonic development|heart morphogenesis|nucleoplasm|cytoplasm|transcription, DNA-templated|vitellogenesis|cell aging|zinc ion binding|nuclear speck|intracellular membrane-bounded organelle|positive regulation of T cell differentiation|positive regulation of Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of fibroblast proliferation|developmental growth|artery morphogenesis ZMIZ2 2440.88823337523 2325.28047866859 2556.49598808188 1.09943553542654 0.136763015337068 0.334806217431666 1 11.8166 12.2082 14.0766 12.6232 GeneID:83637,Genbank:XM_005249866.2,HGNC:HGNC:22229,MIM:611196 zinc finger MIZ-type containing 2 GO:0005634,GO:0005654,GO:0005739,GO:0006351,GO:0008270,GO:0030374,GO:0043596,GO:0045944 nucleus|nucleoplasm|mitochondrion|transcription, DNA-templated|zinc ion binding|ligand-dependent nuclear receptor transcription coactivator activity|nuclear replication fork|positive regulation of transcription from RNA polymerase II promoter ZMPSTE24 1858.19101807076 1940.67251468314 1775.70952145837 0.914996996156403 -0.128161087706392 0.388586730827264 1 31.5614 27.877 28.5498 26.4251 GeneID:10269,Genbank:NM_005857.4,HGNC:HGNC:12877,MIM:606480 zinc metallopeptidase STE24 GO:0004222,GO:0005637,GO:0006508,GO:0006998,GO:0008235,GO:0016020,GO:0030176,GO:0030327,GO:0046872,GO:0070062,GO:0071586 metalloendopeptidase activity|nuclear inner membrane|proteolysis|nuclear envelope organization|metalloexopeptidase activity|membrane|integral component of endoplasmic reticulum membrane|prenylated protein catabolic process|metal ion binding|extracellular exosome|CAAX-box protein processing hsa00900 Terpenoid backbone biosynthesis ZMYM1 178.846196199934 202.107263356862 155.585129043006 0.769814634362193 -0.377416997496626 0.115548692476471 1 1.04533 0.950125 0.813326 0.621429 GeneID:79830,Genbank:NM_001289088.1,HGNC:HGNC:26253 zinc finger MYM-type containing 1 GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0008270,GO:0046983 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|zinc ion binding|protein dimerization activity ZMYM2 235.460245228992 254.726182809077 216.194307648907 0.848732176899733 -0.236618721339538 0.54415681719433 1 0.579575 0.530824 0.562207 0.310942 GeneID:7750,Genbank:NM_001353159.1,HGNC:HGNC:12989,MIM:602221 zinc finger MYM-type containing 2 ZMYM3 1988.06462321779 1904.89257868942 2071.23666774617 1.08732465595052 0.120782767962201 0.399526130205332 1 9.46693 10.0505 10.8737 11.0283 GeneID:9203,Genbank:NM_001171162.1,HGNC:HGNC:13054,MIM:300061 zinc finger MYM-type containing 3 GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0007010,GO:0007275,GO:0008270,GO:0022604 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|cytoskeleton organization|multicellular organism development|zinc ion binding|regulation of cell morphogenesis ZMYM4 653.671287705075 673.843748334514 633.498827075636 0.940127186222925 -0.0890721481815244 0.77431079327479 1 3.33945 2.67317 3.44641 2.37885 GeneID:9202,Genbank:XM_005271328.4,HGNC:HGNC:13055,MIM:613568 zinc finger MYM-type containing 4 GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0007010,GO:0007275,GO:0008270,GO:0022604 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|cytoskeleton organization|multicellular organism development|zinc ion binding|regulation of cell morphogenesis ZMYM5 85.8279320298442 94.101483829212 77.5543802304764 0.824156825956459 -0.279009205898842 0.391742728566286 1 0.668598 0.637921 0.764137 0.391384 GeneID:9205,Genbank:XM_024449435.1,HGNC:HGNC:13029,MIM:616443 zinc finger MYM-type containing 5 GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0006351,GO:0007010,GO:0007275,GO:0008270,GO:0022604 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|transcription, DNA-templated|cytoskeleton organization|multicellular organism development|zinc ion binding|regulation of cell morphogenesis ZMYM6 149.973390063428 158.424281998611 141.522498128245 0.893313173604828 -0.162762057502866 0.550654983934521 1 1.20553 1.01275 1.15576 0.887235 GeneID:9204,Genbank:NM_007167.3,HGNC:HGNC:13050,MIM:613567 zinc finger MYM-type containing 6 GO:0000981,GO:0003677,GO:0005654,GO:0005737,GO:0007010,GO:0007275,GO:0008270,GO:0022604 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleoplasm|cytoplasm|cytoskeleton organization|multicellular organism development|zinc ion binding|regulation of cell morphogenesis ZMYND10 29.5318770242923 28.0585314254086 31.005222623176 1.10501943787047 0.144071747601042 0.861553145743654 1 0.434547 0.469257 0.260872 0.79607 GeneID:51364,Genbank:NM_001308379.1,HGNC:HGNC:19412,MIM:607070 zinc finger MYND-type containing 10 GO:0005737,GO:0034451,GO:0036158,GO:0036159,GO:0044458,GO:0046872 cytoplasm|centriolar satellite|outer dynein arm assembly|inner dynein arm assembly|motile cilium assembly|metal ion binding ZMYND11 1048.91831336987 1102.81178517464 995.024841565107 0.902261704981269 -0.148382140656353 0.351416603053519 1 7.09026 6.26407 6.62215 5.32686 GeneID:10771,Genbank:XM_006717376.2,HGNC:HGNC:16966,MIM:608668 zinc finger MYND-type containing 11 GO:0000977,GO:0003682,GO:0003690,GO:0003712,GO:0003714,GO:0005634,GO:0005654,GO:0005694,GO:0006351,GO:0007049,GO:0008270,GO:0008283,GO:0016032,GO:0016569,GO:0034243,GO:0035064,GO:0042393,GO:0043124,GO:0046329,GO:0051607,GO:2001237 RNA polymerase II regulatory region sequence-specific DNA binding|chromatin binding|double-stranded DNA binding|transcription cofactor activity|transcription corepressor activity|nucleus|nucleoplasm|chromosome|transcription, DNA-templated|cell cycle|zinc ion binding|cell proliferation|viral process|covalent chromatin modification|regulation of transcription elongation from RNA polymerase II promoter|methylated histone binding|histone binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of JNK cascade|defense response to virus|negative regulation of extrinsic apoptotic signaling pathway ZMYND15 0.732605553250947 0.980142803914724 0.48506830258717 0.494895540374107 -1.01480405310505 0.981056166846518 1 0 0.0150989 0.0159834 0 GeneID:84225,Genbank:NM_001267822.1,HGNC:HGNC:20997,MIM:614312 zinc finger MYND-type containing 15 GO:0005634,GO:0005737,GO:0006351,GO:0007286,GO:0042826,GO:0045892,GO:0046872 nucleus|cytoplasm|transcription, DNA-templated|spermatid development|histone deacetylase binding|negative regulation of transcription, DNA-templated|metal ion binding ZMYND19 987.485535279952 1037.25214652025 937.718924039656 0.904041439861556 -0.145539189821553 0.323427110249635 1 14.825 16.6259 14.0478 14.1352 GeneID:116225,Genbank:NM_138462.2,HGNC:HGNC:21146,MIM:611424 zinc finger MYND-type containing 19 GO:0005737,GO:0005886,GO:0016020,GO:0045202,GO:0046872 cytoplasm|plasma membrane|membrane|synapse|metal ion binding ZMYND8 1287.16321493286 1276.40968032457 1297.91674954116 1.01684966006457 0.0241063943258897 0.859451410526095 1 3.71717 3.35436 4.01195 3.14349 GeneID:23613,Genbank:NM_001281781.2,HGNC:HGNC:9397,MIM:615713 zinc finger MYND-type containing 8 GO:0000977,GO:0001106,GO:0003682,GO:0003712,GO:0005634,GO:0005737,GO:0006351,GO:0030336,GO:0035064,GO:0043197,GO:0043198,GO:0046872,GO:0047485,GO:0051491,GO:0060999,GO:0070491,GO:0070577,GO:0098815,GO:1902897,GO:1902952,GO:1903758 RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II transcription corepressor activity|chromatin binding|transcription cofactor activity|nucleus|cytoplasm|transcription, DNA-templated|negative regulation of cell migration|methylated histone binding|dendritic spine|dendritic shaft|metal ion binding|protein N-terminus binding|positive regulation of filopodium assembly|positive regulation of dendritic spine development|repressing transcription factor binding|lysine-acetylated histone binding|modulation of excitatory postsynaptic potential|regulation of postsynaptic density protein 95 clustering|positive regulation of dendritic spine maintenance|negative regulation of transcription from RNA polymerase II promoter by histone modification ZNF10 34.0724351189262 28.8847867501605 39.2600834876919 1.3591958918469 0.442753397113092 0.363815973809776 1 0.238693 0.172032 0.334026 0.238758 GeneID:7556,Genbank:NM_015394.4,HGNC:HGNC:12879,MIM:194538 zinc finger protein 10 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF100 38.5233586082419 31.9692939859595 45.0774232305243 1.41002248126974 0.495718165005488 0.278578347235517 1 0.275393 0.252596 0.356831 0.256406 GeneID:163227,Genbank:NM_001351672.1,HGNC:HGNC:12880,MIM:603982 zinc finger protein 100 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF101 222.369278352556 187.38652098878 257.352035716331 1.37337538665196 0.457726013278615 0.0387512656361292 0.753204211684763 1.17563 1.2458 1.77666 1.4864 GeneID:94039,Genbank:XM_024451787.1,HGNC:HGNC:12881,MIM:603983 zinc finger protein 101 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF106 1597.88370004098 1611.78388804594 1583.98351203601 0.982751796803455 -0.0251009984999475 0.932877538391062 1 5.11183 4.46938 5.61828 3.88821 GeneID:64397,Genbank:NM_001284307.1,HGNC:HGNC:12886 zinc finger protein 106 GO:0003723,GO:0005730,GO:0005829,GO:0008286,GO:0016020,GO:0017124,GO:0046872 RNA binding|nucleolus|cytosol|insulin receptor signaling pathway|membrane|SH3 domain binding|metal ion binding ZNF107 59.3024321300267 42.9811875473383 75.6236767127151 1.75945991788676 0.815132648543578 0.186873623727568 1 0.204724 0.119378 0.348863 0.124546 GeneID:51427,Genbank:XM_024446791.1,HGNC:HGNC:12887,MIM:603989 zinc finger protein 107 GO:0003677,GO:0003700,GO:0003714,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF112 43.671382030744 43.2311275758709 44.111636485617 1.02036747499127 0.0290888177568127 0.967639336991274 1 0.341391 0.304755 0.462402 0.261196 GeneID:7771,Genbank:NM_001348282.1,HGNC:HGNC:12892,MIM:603994 zinc finger protein 112 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF114 9.73833634985917 9.30154798208194 10.1751247176364 1.09391734980428 0.129503740386507 0.93935022056364 1 0.0977196 0.0569271 0.0462878 0.140122 GeneID:163071,Genbank:NM_153608.3,HGNC:HGNC:12894,MIM:603996 zinc finger protein 114 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0042802,GO:0046872,GO:0070062 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|identical protein binding|metal ion binding|extracellular exosome ZNF12 183.712345741077 152.217049907436 215.207641574718 1.41382086767276 0.499599341016234 0.071940380374356 0.928200388965456 1.05252 1.01842 1.74031 1.19487 GeneID:7559,Genbank:NM_006956.2,HGNC:HGNC:12902,MIM:194536 zinc finger protein 12 GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005813,GO:0006351,GO:0045892,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|centrosome|transcription, DNA-templated|negative regulation of transcription, DNA-templated|metal ion binding ZNF121 52.0989285111069 51.8504990572557 52.3473579649581 1.0095825289387 0.0137588494747164 0.99825576412577 1 0.724837 0.680166 0.877547 0.533018 GeneID:7675,Genbank:XM_017027239.1,HGNC:HGNC:12904,MIM:194628 zinc finger protein 121 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF124 52.720680875295 52.1386567053654 53.3027050452247 1.02232601323884 0.0318553358852434 0.942899269252399 1 0.388593 0.258956 0.308922 0.430927 GeneID:7678,Genbank:NM_001243740.2,HGNC:HGNC:12907,MIM:194631 zinc finger protein 124 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF131 574.091887499035 608.752529770157 539.431245227914 0.886125673155862 -0.174416774006294 0.319950150062472 1 4.17358 3.73983 3.85506 3.14458 GeneID:7690,Genbank:NM_001330707.1,HGNC:HGNC:12915,MIM:604073 zinc finger protein 131 GO:0000981,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0045111,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|intermediate filament cytoskeleton|metal ion binding ZNF132 73.9687828130453 68.4550917940132 79.4824738320775 1.16108928859882 0.215478920752632 0.547953860340158 1 0.682268 0.819166 0.89068 0.785465 GeneID:7691,Genbank:NM_003433.3,HGNC:HGNC:12916,MIM:604074 zinc finger protein 132 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF133 152.457184338211 151.294742033314 153.619626643109 1.01536659224604 0.0220006981781452 0.945277058605028 1 0.433305 0.468553 0.448925 0.45485 GeneID:7692,Genbank:NM_001352450.1,HGNC:HGNC:12917,MIM:604075 zinc finger protein 133 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF134 374.690061143497 307.374528226615 442.005594060378 1.43800332646466 0.524067013098849 0.00502875474724225 0.282598372041515 2.21252 2.08993 3.38183 2.81121 GeneID:7693,Genbank:NM_003435.4,HGNC:HGNC:12918,MIM:604076 zinc finger protein 134 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF136 66.4689822922011 62.6604788647868 70.2774857196154 1.12155998474358 0.165506782597909 0.62857340285889 1 0.602922 0.431726 0.64356 0.50917 GeneID:7695,Genbank:NM_001348014.1,HGNC:HGNC:12920,MIM:604078 zinc finger protein 136 GO:0000122,GO:0003677,GO:0003714,GO:0005634,GO:0006366,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|transcription corepressor activity|nucleus|transcription from RNA polymerase II promoter|metal ion binding ZNF138 83.7448063361745 83.1660255069872 84.3235871653618 1.0139186843584 0.0199419537446116 0.939855755618517 1 0.633375 0.399182 0.482921 0.478314 GeneID:7697,Genbank:NM_001271638.1,HGNC:HGNC:12922,MIM:604080 zinc finger protein 138 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF14 28.2659715468875 30.84507235799 25.6868707357851 0.83277064283272 -0.264008883822284 0.647030107451508 1 0.335318 0.322576 0.301199 0.250029 GeneID:7561,Genbank:NM_021030.2,HGNC:HGNC:12924,MIM:194556 zinc finger protein 14 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF140 169.674620165282 153.264836296251 186.084404034313 1.21413631809598 0.27993041039117 0.259464214704103 1 1.03839 1.3108 1.42809 1.52842 GeneID:7699,Genbank:XM_017019925.2,HGNC:HGNC:12925,MIM:604082 zinc finger protein 140 GO:0000122,GO:0001227,GO:0003700,GO:0005634,GO:0006351,GO:0043565,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|sequence-specific DNA binding|metal ion binding ZNF141 40.8721055020017 35.6879514477707 46.0562595562326 1.29052684975869 0.367960157403019 0.59625483999841 1 0.0991058 0.0655859 0.146082 0.0632982 GeneID:7700,Genbank:NM_003441.3,HGNC:HGNC:12926,MIM:194648 zinc finger protein 141 GO:0003677,GO:0005634,GO:0006355,GO:0006366,GO:0009653,GO:0035108,GO:0046872 DNA binding|nucleus|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|anatomical structure morphogenesis|limb morphogenesis|metal ion binding ZNF142 645.213917767918 688.018618372555 602.40921716328 0.875571098044154 -0.19170376188124 0.246542057883172 1 3.49285 3.34621 3.17647 2.89232 GeneID:7701,Genbank:XM_011511788.2,HGNC:HGNC:12927,MIM:604083 zinc finger protein 142 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF143 253.316872828746 271.090644172409 235.543101485083 0.868872115465857 -0.202784244614318 0.348367163004508 1 2.01764 1.92229 1.83826 1.60398 GeneID:7702,Genbank:NM_003442.5,HGNC:HGNC:12928,MIM:603433 zinc finger protein 143 GO:0000978,GO:0001077,GO:0005654,GO:0006357,GO:0006359,GO:0006366,GO:0006383,GO:0042795,GO:0045944,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleoplasm|regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter|snRNA transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF146 650.878288033193 694.445347526085 607.311228540302 0.874527031830234 -0.193425116018091 0.498629719720056 1 6.50548 5.30561 6.077 4.43163 GeneID:7705,Genbank:NM_007145.2,HGNC:HGNC:12931,MIM:601505 zinc finger protein 146 ZNF148 197.533200513332 193.900511037426 201.165889989239 1.03746962250353 0.0530690944305273 0.892590707045399 1 0.756103 0.515625 0.851961 0.4625 GeneID:7707,Genbank:NM_001348426.2,HGNC:HGNC:12933,MIM:601897 zinc finger protein 148 GO:0000122,GO:0000978,GO:0001078,GO:0005634,GO:0005794,GO:0006366,GO:0006461,GO:0006968,GO:0007276,GO:0010629,GO:0021762,GO:0043565,GO:0045892,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|Golgi apparatus|transcription from RNA polymerase II promoter|protein complex assembly|cellular defense response|gamete generation|negative regulation of gene expression|substantia nigra development|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF154 1.48628770813257 1.51824048055703 1.45433493570811 0.957908153769244 -0.062040760902852 1 1 0 0.011919 0.0121463 0.00564499 GeneID:7710,Genbank:NM_001085384.2,HGNC:HGNC:12939,MIM:604085 zinc finger protein 154 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0045892,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|metal ion binding ZNF155 175.561138430189 177.633119224318 173.489157636061 0.976671233346845 -0.034055090362257 0.903332622723412 1 1.0898 1.08334 1.02653 1.10172 GeneID:7711,Genbank:XM_011527279.3,HGNC:HGNC:12940,MIM:604086 zinc finger protein 155 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF157 2.18900705261746 1.47021420587209 2.90779989936283 1.97780696700452 0.983901626635446 0.767802999758984 1 0 0.0163473 0.0164916 0.0460328 GeneID:7712,Genbank:NM_003446.3,HGNC:HGNC:12942,MIM:300024 zinc finger protein 157 GO:0000122,GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF16 128.886135735187 112.906493547224 144.865777923151 1.28305975477452 0.359588361315666 0.475135523526426 1 1.1791 1.13921 1.11151 2.07708 GeneID:7564,Genbank:NM_006958.2,HGNC:HGNC:12947,MIM:601262 zinc finger protein 16 GO:0003677,GO:0003700,GO:0005634,GO:0005730,GO:0006351,GO:0006355,GO:0007049,GO:0008284,GO:0033674,GO:0043066,GO:0045648,GO:0045654,GO:0046872,GO:0051301,GO:0051781,GO:0072707,GO:1901989 DNA binding|DNA binding transcription factor activity|nucleus|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|cell cycle|positive regulation of cell proliferation|positive regulation of kinase activity|negative regulation of apoptotic process|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|metal ion binding|cell division|positive regulation of cell division|cellular response to sodium dodecyl sulfate|positive regulation of cell cycle phase transition ZNF160 110.86071247636 107.323603026953 114.397821925766 1.06591484724042 0.0920921900944012 0.808116725863877 1 0.512403 0.471463 0.605672 0.362653 GeneID:90338,Genbank:NM_001322135.1,HGNC:HGNC:12948,MIM:600398 zinc finger protein 160 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0030097,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|hemopoiesis|metal ion binding ZNF165 20.4406096139175 17.1328817582918 23.7483374695432 1.38612626904109 0.471058685629437 0.453415356953889 1 0.211343 0.119026 0.321877 0.212052 GeneID:7718,Genbank:NM_003447.3,HGNC:HGNC:12953,MIM:600834 zinc finger protein 165 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF169 37.6944108132443 40.4926129179745 34.8962087085141 0.861791971271478 -0.21458843698302 0.661104293974491 1 0.236837 0.262207 0.218732 0.147434 GeneID:169841,Genbank:NM_001301275.1,HGNC:HGNC:12957,MIM:603404 zinc finger protein 169 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF17 77.0367350387235 67.3210615109357 86.7524085665113 1.2886369676809 0.365845887676499 0.272537244655728 1 0.786759 0.781366 1.06955 0.911353 GeneID:7565,Genbank:NM_001330617.1,HGNC:HGNC:12958 zinc finger protein 17 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF174 197.738034313878 181.265532791867 214.210535835889 1.1817499583986 0.240924813909056 0.300699433080689 1 1.94057 2.01361 2.4302 2.31664 GeneID:7727,Genbank:NM_003450.2,HGNC:HGNC:12963,MIM:603900 zinc finger protein 174 GO:0000122,GO:0000981,GO:0001227,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0005886,GO:0006351,GO:0015629,GO:0042803,GO:0043565,GO:0044212,GO:0045892,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|plasma membrane|transcription, DNA-templated|actin cytoskeleton|protein homodimerization activity|sequence-specific DNA binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|metal ion binding ZNF175 125.306319173334 122.160015254621 128.452623092047 1.05151119066505 0.0724642039746493 0.833936058164298 1 1.00903 0.997247 1.29042 0.849671 GeneID:7728,Genbank:NM_007147.3,HGNC:HGNC:12964,MIM:601139 zinc finger protein 175 GO:0000122,GO:0000977,GO:0001227,GO:0001228,GO:0003700,GO:0005654,GO:0005829,GO:0045111,GO:0045944,GO:0046872,GO:0051607 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleoplasm|cytosol|intermediate filament cytoskeleton|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|defense response to virus ZNF18 174.298458014667 139.744750795293 208.852165234041 1.4945260129304 0.579688008022421 0.0161597380712663 0.529251203244782 0.537292 0.709761 0.955448 1.1206 GeneID:7566,Genbank:XM_024450911.1,HGNC:HGNC:12969,MIM:194524 zinc finger protein 18 GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZNF180 130.317696086613 116.19291453687 144.442477636355 1.24312638349838 0.313972976661944 0.271372218734389 1 0.549321 0.572638 0.863965 0.559559 GeneID:7733,Genbank:NM_001291633.1,HGNC:HGNC:12970,MIM:606740 zinc finger protein 180 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF181 63.5157402219239 52.8786681358554 74.1528123079924 1.40231996988804 0.487815569250451 0.180295276170036 1 0.258131 0.279184 0.421085 0.343315 GeneID:339318,Genbank:XM_006723183.3,HGNC:HGNC:12971,MIM:606741 zinc finger protein 181 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF182 38.1739086429795 34.6597823691711 41.6880349167879 1.20277832309381 0.266370772486749 0.582574275571011 1 0.309603 0.218131 0.437673 0.235922 GeneID:7569,Genbank:NM_001178099.1,HGNC:HGNC:13001,MIM:314993 zinc finger protein 182 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF184 138.789452739237 125.878672716432 151.700232762042 1.20513053949797 0.269189427356589 0.301596065137033 1 1.19349 1.10081 1.5848 1.24615 GeneID:7738,Genbank:NM_007149.2,HGNC:HGNC:12975,MIM:602277 zinc finger protein 184 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding ZNF185 110.335038202648 114.530595232258 106.139481173037 0.926734738065362 -0.109771643676188 0.700605228334418 1 0.724154 0.807244 0.78004 0.700356 GeneID:7739,Genbank:XM_017029821.1,HGNC:HGNC:12976,MIM:300381 zinc finger protein 185 with LIM domain GO:0005737,GO:0005925,GO:0008270,GO:0015629,GO:0051015 cytoplasm|focal adhesion|zinc ion binding|actin cytoskeleton|actin filament binding ZNF189 118.360908084469 116.999552551406 119.722263617531 1.02327112375005 0.0331884491556784 0.913603066319726 1 0.60989 0.461864 0.692041 0.466598 GeneID:7743,Genbank:XM_006717281.3,HGNC:HGNC:12980,MIM:603132 zinc finger protein 189 GO:0000122,GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF19 27.2954128618813 35.6879514477707 18.9028742759919 0.529671037679375 -0.916831470410422 0.0977658883773123 1 0.476859 0.312414 0.240943 0.177272 GeneID:7567,Genbank:NM_006961.3,HGNC:HGNC:12981,MIM:194525 zinc finger protein 19 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF195 78.4007983477409 79.7453343483936 77.0562623470883 0.966279256043278 -0.0494879047015328 0.935048632230747 1 0.659733 0.435886 0.615114 0.561903 GeneID:7748,Genbank:NM_007152.4,HGNC:HGNC:12986,MIM:602187 zinc finger protein 195 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding ZNF2 106.375520822498 101.288858724302 111.462182920695 1.10043872864718 0.138078819615924 0.618726410688721 1 1.15303 0.822194 1.11199 1.04939 GeneID:7549,Genbank:NM_001291605.1,HGNC:HGNC:12991,MIM:194500 zinc finger protein 2 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0008270 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding ZNF20 72.4985085539414 79.0729665028044 65.9240506050785 0.833711614989686 -0.262379660345862 0.453276449490623 1 0.735948 0.76026 0.821061 0.480909 GeneID:7568,Genbank:NM_001203250.1,HGNC:HGNC:12992,MIM:194557 zinc finger protein 20 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF200 126.807399446627 127.598826950836 126.015971942417 0.987595066144067 -0.0180084658461843 0.958143156254219 1 1.09853 1.10717 1.26109 1.06175 GeneID:7752,Genbank:XM_005255556.1,HGNC:HGNC:12993,MIM:603231 zinc finger protein 200 GO:0003676,GO:0005634,GO:0006351,GO:0006355,GO:0046872 nucleic acid binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF202 196.301766484662 189.048840293392 203.554692675932 1.07673071339675 0.106657481986028 0.656204751313176 1 1.04539 1.12216 1.26954 1.14829 GeneID:7753,Genbank:NM_001301780.1,HGNC:HGNC:12994,MIM:603430 zinc finger protein 202 ZNF205 399.39876977184 363.607260937018 435.190278606663 1.19686905449901 0.25926532040273 0.164337319904692 1 5.99125 6.36363 7.64925 7.48898 GeneID:7755,Genbank:NM_003456.2,HGNC:HGNC:12996,MIM:603436 zinc finger protein 205 GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0005739,GO:0006351,GO:0006355,GO:0008270,GO:0010729,GO:1901030 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|mitochondrion|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|positive regulation of hydrogen peroxide biosynthetic process|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ZNF207 3968.90906100716 4075.25840006138 3862.55972195293 0.947807314965538 -0.0773342994752131 0.582442177233402 1 48.3299 45.5617 46.8638 42.7405 GeneID:7756,Genbank:NM_001098507.1,HGNC:HGNC:12998,MIM:603428 zinc finger protein 207 GO:0000777,GO:0001578,GO:0003677,GO:0005634,GO:0005737,GO:0005819,GO:0005874,GO:0007059,GO:0008017,GO:0046785,GO:0046872,GO:0051301,GO:0090307,GO:1990047 condensed chromosome kinetochore|microtubule bundle formation|DNA binding|nucleus|cytoplasm|spindle|microtubule|chromosome segregation|microtubule binding|microtubule polymerization|metal ion binding|cell division|mitotic spindle assembly|spindle matrix ZNF208 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.00308724 0 0 0 GeneID:7757,Genbank:NM_001329974.1,HGNC:HGNC:12999,MIM:603977 zinc finger protein 208 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF211 221.736366476985 205.057500423714 238.415232530257 1.16267501572786 0.217447899289838 0.327855001862788 1 1.59421 1.7311 1.87165 2.00038 GeneID:10520,Genbank:NM_001265597.2,HGNC:HGNC:13003,MIM:601856 zinc finger protein 211 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF212 485.722087599756 478.0996385497 493.344536649812 1.03188644556678 0.0452842174361544 0.822606289806822 1 4.65444 5.31705 5.41514 5.29631 GeneID:7988,Genbank:NM_012256.3,HGNC:HGNC:13004,MIM:602386 zinc finger protein 212 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270,GO:0042802 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|identical protein binding ZNF213 273.386506817343 255.04376642251 291.729247212176 1.14383994286256 0.193885190408674 0.346945272656654 1 3.70784 3.13015 3.82943 4.37479 GeneID:7760,Genbank:NM_004220.2,HGNC:HGNC:13005,MIM:608387 zinc finger protein 213 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF214 1.72381876005596 0.538097676642304 2.90953984346962 5.40708493971758 2.43485101984636 0.443297956929474 1 0.00427366 0 0.016696 0.00387751 GeneID:7761,Genbank:XM_006718309.4,HGNC:HGNC:13006,MIM:605015 zinc finger protein 214 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding ZNF217 1196.20778636232 1264.58032309269 1127.83524963196 0.891865252871953 -0.165102337318037 0.314707443333346 1 6.69864 6.14437 6.42509 5.02812 GeneID:7764,Genbank:XM_011529036.1,HGNC:HGNC:13009,MIM:602967 zinc finger protein 217 ZNF219 490.141027471541 423.491007524332 556.791047418751 1.3147647471281 0.394804678974343 0.0279981718382713 0.668561867500627 5.69835 5.54596 6.85132 7.80664 GeneID:51222,Genbank:NM_001102454.1,HGNC:HGNC:13011,MIM:605036 zinc finger protein 219 GO:0000122,GO:0000978,GO:0001078,GO:0001505,GO:0003677,GO:0003700,GO:0004969,GO:0005634,GO:0006351,GO:0006355,GO:0007165,GO:0007275,GO:0016021,GO:0032332,GO:0045892,GO:0045944,GO:0046872,GO:0060174 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|regulation of neurotransmitter levels|DNA binding|DNA binding transcription factor activity|histamine receptor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|signal transduction|multicellular organism development|integral component of membrane|positive regulation of chondrocyte differentiation|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|limb bud formation ZNF22 626.018057787225 685.020355031018 567.015760543431 0.827735637896127 -0.272758021359068 0.102406754327711 1 12.7773 12.823 10.9086 10.4503 GeneID:7570,Genbank:NM_006963.4,HGNC:HGNC:13012,MIM:194529 zinc finger protein 22 GO:0003677,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0008270,GO:0042476 DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|odontogenesis ZNF221 14.8824079709461 10.3777433353665 19.3870726065257 1.86813953477304 0.901602216614461 0.224213742009553 1 0.105254 0.0494762 0.129877 0.0395118 GeneID:7638,Genbank:XM_017027233.1,HGNC:HGNC:13014 zinc finger protein 221 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF222 64.9222704475595 60.0660430309451 69.7784978641739 1.16169626536286 0.21623291406541 0.533640186939982 1 0.827551 0.509551 0.761833 0.777267 GeneID:7673,Genbank:XM_017027237.1,HGNC:HGNC:13015,MIM:617357 zinc finger protein 222 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF223 99.075478314686 92.9772622012424 105.17369442813 1.13117650421335 0.177824059200085 0.557498900380744 1 0.448862 0.489749 0.597448 0.459983 GeneID:7766,Genbank:XM_017027258.1,HGNC:HGNC:13016 zinc finger protein 223 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF224 121.887385696704 128.425082275588 115.349689117819 0.898186608674227 -0.154912882170125 0.586904430491523 1 0.838971 0.807131 0.767512 0.663907 GeneID:7767,Genbank:NM_001321645.1,HGNC:HGNC:13017,MIM:194555 zinc finger protein 224 GO:0000122,GO:0001227,GO:0003700,GO:0005634,GO:0006351,GO:0017053,GO:0031965,GO:0043565,GO:0045892,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|transcriptional repressor complex|nuclear membrane|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding ZNF225 73.2345489936986 73.288162228686 73.1809357587113 0.998536919650951 -0.00211232439122845 1 1 0.489555 0.355259 0.453003 0.409015 GeneID:7768,Genbank:XM_011527286.2,HGNC:HGNC:13018 zinc finger protein 225 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF226 379.199584478156 371.198463339803 387.200705616508 1.04310966735349 0.0608908436004247 0.761862975068605 1 1.79548 2.12281 2.09428 2.15115 GeneID:7769,Genbank:NM_001319090.1,HGNC:HGNC:13019 zinc finger protein 226 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF227 199.098827289586 171.386652512711 226.811002066461 1.32338778277754 0.404235866088211 0.0974972941618597 1 1.73356 1.19466 2.01338 1.78282 GeneID:7770,Genbank:XM_017027274.2,HGNC:HGNC:13020 zinc finger protein 227 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF229 0.490071401957362 0.980142803914724 0 0 -Inf 0.757480882778577 1 0 0.0137405 0 0 GeneID:7772,Genbank:NM_001278510.2,HGNC:HGNC:13022 zinc finger protein 229 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF23 101.036792094414 111.436279341351 90.6373048474756 0.813355447464605 -0.298042127301272 0.321205421451994 1 0.997972 1.01329 0.995367 0.688087 GeneID:7571,Genbank:NM_001304494.1,HGNC:HGNC:13023,MIM:194527 zinc finger protein 23 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF230 73.2591649115714 86.4142288770569 60.1041009460858 0.695534771612636 -0.523805454197265 0.127581985276345 1 0.78812 0.760612 0.640645 0.414266 GeneID:7773,Genbank:NM_006300.3,HGNC:HGNC:13024 zinc finger protein 230 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF232 291.606347255496 256.139579086011 327.073115424981 1.27693313384868 0.352682980803664 0.270166057710609 1 1.63648 1.81193 1.9768 2.70495 GeneID:7775,Genbank:XM_017025021.1,HGNC:HGNC:13026,MIM:616463 zinc finger protein 232 GO:0003677,GO:0003700,GO:0005634,GO:0005829,GO:0006351,GO:0043231,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|cytosol|transcription, DNA-templated|intracellular membrane-bounded organelle|metal ion binding ZNF233 1.45890304905161 0.980142803914724 1.93766329418849 1.97691936975856 0.983254030793153 0.869518558966023 1 0 0.00941592 0.00475481 0.0132666 GeneID:353355,Genbank:XM_017026760.2,HGNC:HGNC:30946 zinc finger protein 233 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF234 139.134796909698 133.854085316696 144.4155085027 1.0789025091092 0.109564507106619 0.669649836449798 1 1.05756 0.895539 0.947351 0.999099 GeneID:10780,Genbank:XM_017026152.1,HGNC:HGNC:13027,MIM:604750 zinc finger protein 234 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF235 29.7207414686224 30.84507235799 28.5964105792547 0.927098184350577 -0.109205959300117 0.870139012520427 1 0.232329 0.213131 0.266161 0.184314 GeneID:9310,Genbank:XM_005259412.5,HGNC:HGNC:12866,MIM:604749 zinc finger protein 235 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF236 153.594119332771 154.51351943806 152.674719227483 0.988099421867652 -0.0172718828152743 0.978200846608291 1 0.674699 0.58613 0.677775 0.494024 GeneID:7776,Genbank:XM_011526168.2,HGNC:HGNC:13028,MIM:604760 zinc finger protein 236 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872,GO:0071333 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding|cellular response to glucose stimulus ZNF239 86.7810330119603 107.159906892682 66.4021591312385 0.619654878925367 -0.69046317469884 0.0770539151932073 0.94157495521624 0.501189 0.325524 0.302633 0.208145 GeneID:8187,Genbank:XM_011540234.2,HGNC:HGNC:13031,MIM:601069 zinc finger protein 239 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF24 440.230138691137 509.702305646686 370.757971735588 0.727401009624997 -0.459177166646808 0.0119415858896338 0.445971779139093 3.41347 2.99904 2.54765 2.15963 GeneID:7572,Genbank:NM_006965.3,HGNC:HGNC:13032,MIM:194534 zinc finger protein 24 GO:0003700,GO:0005634,GO:0006351,GO:0042552,GO:0043565,GO:0046872 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|myelination|sequence-specific DNA binding|metal ion binding ZNF248 159.425370553926 157.934210596653 160.916530511198 1.01888330529071 0.0269888262642535 0.905692157273844 1 0.504932 0.383823 0.548874 0.385189 GeneID:57209,Genbank:NM_001352476.1,HGNC:HGNC:13041 zinc finger protein 248 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF25 62.5516219818231 63.5543777744395 61.5488661892066 0.968444163007138 -0.0462592242466825 0.919547576686452 1 0.429796 0.430766 0.414931 0.414197 GeneID:219749,Genbank:NM_001329652.1,HGNC:HGNC:13043,MIM:194528 zinc finger protein 25 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF250 123.678976562606 118.931429194767 128.426523930445 1.07983671599648 0.110813176433523 0.698963730916056 1 0.440238 0.430622 0.492016 0.489544 GeneID:58500,Genbank:NM_001109689.3,HGNC:HGNC:13044 zinc finger protein 250 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0042802,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|identical protein binding|metal ion binding ZNF251 224.488234209177 234.768542498626 214.207925919728 0.912421756509314 -0.132227247060337 0.558907068479814 1 1.60376 1.62262 1.57237 1.46773 GeneID:90987,Genbank:NM_138367.1,HGNC:HGNC:13045 zinc finger protein 251 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF253 45.8978159734346 28.2986627988333 63.4969691480358 2.24381517951632 1.16595384770412 0.00610247883280813 0.31225974755992 0.333174 0.26673 0.893975 0.568542 GeneID:56242,Genbank:NM_001331133.1,HGNC:HGNC:13497,MIM:606954 zinc finger protein 253 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270,GO:0045892 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|negative regulation of transcription, DNA-templated ZNF254 83.8013948409928 67.7631066382081 99.8396830437775 1.4733634273415 0.559113336791207 0.0817405336444307 0.959088928094653 0.216183 0.244278 0.364271 0.351115 GeneID:9534,Genbank:NM_001278677.1,HGNC:HGNC:13047,MIM:604768 zinc finger protein 254 GO:0000122,GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF256 130.505574117882 122.890218030003 138.120930205761 1.12393754702299 0.168561872655408 0.527671886518096 1 1.99333 1.81199 2.13812 2.0759 GeneID:10172,Genbank:NM_005773.2,HGNC:HGNC:13049,MIM:606956 zinc finger protein 256 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0007275,GO:0045892,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|multicellular organism development|negative regulation of transcription, DNA-templated|metal ion binding ZNF257 0.754117140908322 0.538097676642304 0.97013660517434 1.80290056487129 0.850319830201774 1 1 0 0 0.00961626 0 GeneID:113835,Genbank:NM_001316996.1,HGNC:HGNC:13498,MIM:606957 zinc finger protein 257 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding ZNF26 100.050414192475 99.7804268988526 100.320401486098 1.00541162835265 0.00778628011138736 0.98786872785157 1 0.721294 0.691104 0.691784 0.703715 GeneID:7574,Genbank:NM_001330514.1,HGNC:HGNC:13053,MIM:194537 zinc finger protein 26 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF260 85.6911171009144 90.9209240440431 80.4613101577858 0.8849592214748 -0.176317116902475 0.594493271389019 1 0.538935 0.568201 0.586117 0.381497 GeneID:339324,Genbank:XM_011526897.2,HGNC:HGNC:13499,MIM:613749 zinc finger protein 260 ZNF263 652.119447989774 571.508120222252 732.730775757297 1.28210037588328 0.358509215248554 0.0276330820456073 0.66709117638512 4.37434 3.9308 5.14799 5.5687 GeneID:10127,Genbank:XM_017022850.2,HGNC:HGNC:13056,MIM:604191 zinc finger protein 263 GO:0000122,GO:0001227,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0043565,GO:0045892,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|sequence-specific DNA binding|negative regulation of transcription, DNA-templated|metal ion binding ZNF264 369.950418900178 394.807117527164 345.093720273192 0.874081810973046 -0.194159777677032 0.326155080501406 1 1.58342 1.40033 1.55171 1.10976 GeneID:9422,Genbank:NM_003417.4,HGNC:HGNC:13057,MIM:604668 zinc finger protein 264 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF266 386.304584727877 351.931791184304 420.67737827145 1.19533781490955 0.257418396466448 0.163574420860881 1 2.52054 2.425 3.22986 2.73826 GeneID:10781,Genbank:NM_006631.3,HGNC:HGNC:13059,MIM:604751 zinc finger protein 266 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF267 38.092094191483 38.3784398309823 37.8057485519838 0.985077786342524 -0.0216904438820981 1 1 0.129893 0.154429 0.27959 0.150292 GeneID:10308,Genbank:NM_001265588.1,HGNC:HGNC:13060,MIM:604752 zinc finger protein 267 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0007275,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|metal ion binding ZNF268 63.9785386428113 59.1339265017154 68.8231507839073 1.16385220558474 0.218907865971583 0.527448185652691 1 0.389391 0.238145 0.438131 0.321842 GeneID:10795,Genbank:NM_152943.2,HGNC:HGNC:13061,MIM:604753 zinc finger protein 268 GO:0000122,GO:0001934,GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0007346,GO:0008284,GO:0008285,GO:0008588,GO:0015629,GO:0030154,GO:0030335,GO:0043065,GO:0043066,GO:0043497,GO:0045597,GO:0045732,GO:0045944,GO:0046022,GO:0046872,GO:0071157,GO:0071356,GO:0090073 negative regulation of transcription from RNA polymerase II promoter|positive regulation of protein phosphorylation|DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of mitotic cell cycle|positive regulation of cell proliferation|negative regulation of cell proliferation|release of cytoplasmic sequestered NF-kappaB|actin cytoskeleton|cell differentiation|positive regulation of cell migration|positive regulation of apoptotic process|negative regulation of apoptotic process|regulation of protein heterodimerization activity|positive regulation of cell differentiation|positive regulation of protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter during mitotic cell cycle|metal ion binding|negative regulation of cell cycle arrest|cellular response to tumor necrosis factor|positive regulation of protein homodimerization activity ZNF273 46.082694104224 41.7609133699988 50.4044748384492 1.20697730894602 0.271398553823869 0.521348232952254 1 0.112075 0.0899824 0.170738 0.125664 GeneID:10793,Genbank:XM_024446637.1,HGNC:HGNC:13067,MIM:604756 zinc finger protein 273 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF274 513.979882965654 484.671463528138 543.28830240317 1.1209413866629 0.164710842477374 0.339825786947483 1 4.27958 3.94526 4.90587 4.56249 GeneID:10782,Genbank:NM_001278734.1,HGNC:HGNC:13068,MIM:605467 zinc finger protein 274 GO:0003682,GO:0003700,GO:0003714,GO:0005730,GO:0005737,GO:0006351,GO:0006355,GO:0043565,GO:0046872,GO:1900112 chromatin binding|DNA binding transcription factor activity|transcription corepressor activity|nucleolus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|sequence-specific DNA binding|metal ion binding|regulation of histone H3-K9 trimethylation hsa04722 Neurotrophin signaling pathway ZNF275 456.029872431533 472.487322064105 439.572422798962 0.930336968362767 -0.104174739382 0.563120541947155 1 3.40879 3.36867 3.35414 3.01289 GeneID:10838,Genbank:NM_001080485.3,HGNC:HGNC:13069 zinc finger protein 275 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF276 357.178840180921 370.304564430151 344.053115931692 0.929108493332087 -0.106081022872416 0.581090019400435 1 1.41749 1.45156 1.31063 1.56638 GeneID:92822,Genbank:NM_152287.3,HGNC:HGNC:23330,MIM:608460 zinc finger protein 276 GO:0000776,GO:0000777,GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270 kinetochore|condensed chromosome kinetochore|DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding ZNF277 172.042309240533 175.413084932848 168.671533548219 0.961567568421651 -0.056539856977081 0.863229905811857 1 2.21129 1.97216 2.37816 1.73249 GeneID:11179,Genbank:NM_021994.2,HGNC:HGNC:13070,MIM:605465 zinc finger protein 277 GO:0000978,GO:0000979,GO:0005634,GO:0006351,GO:0006355,GO:0046872,GO:0070301,GO:2000772 RNA polymerase II proximal promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding|cellular response to hydrogen peroxide|regulation of cellular senescence ZNF28 70.4399954666086 74.9602901884058 65.9197007448115 0.87939495136863 -0.185416844866195 0.607682378566513 1 0.406533 0.375171 0.448225 0.344674 GeneID:7576,Genbank:XM_006723354.3,HGNC:HGNC:13073 zinc finger protein 28 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF280A 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.0315527 0 GeneID:129025,Genbank:NM_080740.4,HGNC:HGNC:18597 zinc finger protein 280A GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF280B 11.1960428073058 9.7916193840393 12.6004662305723 1.28686233975878 0.363857731593174 0.706317495540414 1 0.0711118 0.0524873 0.0984895 0.0847378 GeneID:140883,Genbank:NM_080764.3,HGNC:HGNC:23022 zinc finger protein 280B GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF280C 91.9727055163643 106.871749244572 77.0736617881562 0.721179005050022 -0.471570697217362 0.231341822353608 1 1.00725 0.774635 0.841014 0.446954 GeneID:55609,Genbank:NM_017666.4,HGNC:HGNC:25955 zinc finger protein 280C GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF280D 154.147032075428 162.89275954602 145.401304604836 0.892619813244416 -0.163882264824349 0.52647029932177 1 0.504701 0.551523 0.513529 0.371169 GeneID:54816,Genbank:NM_001002843.2,HGNC:HGNC:25953 zinc finger protein 280D GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF281 366.441716014162 421.261164577754 311.62226745057 0.739736518942877 -0.434916595095711 0.0218745116642077 0.600929980812952 3.4218 3.35046 2.60214 2.43258 GeneID:23528,Genbank:NM_012482.4,HGNC:HGNC:13075 zinc finger protein 281 GO:0000122,GO:0000978,GO:0001047,GO:0001078,GO:0003700,GO:0003714,GO:0005634,GO:0005654,GO:0006351,GO:0010172,GO:0010629,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0046872,GO:0048863 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|core promoter binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|nucleoplasm|transcription, DNA-templated|embryonic body morphogenesis|negative regulation of gene expression|sequence-specific DNA binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|stem cell differentiation ZNF282 1418.11924754253 1424.084868448 1412.15362663705 0.991621818281127 -0.0121380800382709 0.905106465762369 1 16.3668 18.1072 16.776 17.6527 GeneID:8427,Genbank:NM_003575.3,HGNC:HGNC:13076,MIM:603397 zinc finger protein 282 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270,GO:0045892 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|negative regulation of transcription, DNA-templated ZNF283 91.8335478627975 90.6131490857175 93.0539466398775 1.0269364609749 0.0383469214105357 0.884262244564655 1 0.267833 0.188372 0.242479 0.220119 GeneID:284349,Genbank:XM_017026629.1,HGNC:HGNC:13077 zinc finger protein 283 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF284 73.0779624212183 70.5496475707895 75.6062772716471 1.07167476911609 0.0998671444396015 0.774633530566283 1 0.544836 0.461659 0.507663 0.464521 GeneID:342909,Genbank:XM_024451486.1,HGNC:HGNC:13078 zinc finger protein 284 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF285 21.1592211347612 24.8681629851318 17.4502792843906 0.701711634060939 -0.511049813047503 0.435640784108159 1 0.288864 0.218609 0.199682 0.123889 GeneID:26974,Genbank:NM_001291491.1,HGNC:HGNC:13079 zinc finger protein 285 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF286A 170.301461140542 180.169720128366 160.433202152717 0.890455965843833 -0.167383824862515 0.507670289768808 1 1.14753 0.953731 1.13456 0.808835 GeneID:57335,Genbank:NM_001288645.1,HGNC:HGNC:13501 zinc finger protein 286A GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF286B 22.1395917864113 26.3481858461118 17.9309977267107 0.680540126422284 -0.555247865584653 0.350994142827372 1 0.134829 0.158074 0.122378 0.107427 GeneID:729288,Genbank:NM_001145045.1,HGNC:HGNC:33241 zinc finger protein 286B GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF287 140.459612907114 129.703191382721 151.216034431508 1.16586209498352 0.221397148187042 0.401155833149399 1 0.517985 0.527907 0.596679 0.542762 GeneID:57336,Genbank:XM_011523968.2,HGNC:HGNC:13502 zinc finger protein 287 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0042035,GO:0045893,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of cytokine biosynthetic process|positive regulation of transcription, DNA-templated|metal ion binding ZNF292 79.1448219041611 80.235405750351 78.0542380579713 0.97281539649508 -0.0397620327677443 0.978156458677269 1 0.172761 0.12458 0.205552 0.0850176 GeneID:23036,Genbank:NM_001351444.1,HGNC:HGNC:18410,MIM:616213 zinc finger protein 292 GO:0001077,GO:0003677,GO:0005634,GO:0046872 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding|nucleus|metal ion binding ZNF296 5.4705237147102 8.03324753005756 2.90779989936283 0.361970658626274 -1.46605533782746 0.263611521441198 1 0.137601 0.313024 0.0932732 0.0873751 GeneID:162979,Genbank:NM_145288.2,HGNC:HGNC:15981,MIM:613226 zinc finger protein 296 GO:0000122,GO:0001076,GO:0003676,GO:0005634,GO:0006351,GO:0007283,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|transcription factor activity, RNA polymerase II transcription factor binding|nucleic acid binding|nucleus|transcription, DNA-templated|spermatogenesis|metal ion binding ZNF3 913.319642265489 867.082717182313 959.556567348666 1.10664939841825 0.14619822909436 0.333672926945565 1 6.54917 5.80263 6.90052 6.90804 GeneID:7551,Genbank:NM_001318137.1,HGNC:HGNC:13089,MIM:194510 zinc finger protein 3 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0007275,GO:0008270,GO:0030154,GO:0042802,GO:0045321 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|zinc ion binding|cell differentiation|identical protein binding|leukocyte activation ZNF30 35.3927343564947 40.7425529465071 30.0429157664822 0.737384223465993 -0.43951154497429 0.353722694206252 1 0.275268 0.401444 0.189133 0.289329 GeneID:90075,Genbank:XM_017027424.1,HGNC:HGNC:13090 zinc finger protein 30 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF300 168.814290554161 173.808600558029 163.819980550294 0.942530922085182 -0.0853881445090866 0.745733059620647 1 1.1624 1.08999 1.23439 0.980358 GeneID:91975,Genbank:XM_011537702.2,HGNC:HGNC:13091,MIM:612429 zinc finger protein 300 GO:0001228,GO:0003700,GO:0005634,GO:0005730,GO:0006355,GO:0043565,GO:0045944,GO:0046872 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleolus|regulation of transcription, DNA-templated|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF302 189.082760944986 185.752610648637 192.412911241335 1.03585575766306 0.0508231225300017 0.823054458420392 1 1.88357 1.70119 1.86864 1.65846 GeneID:55900,Genbank:NM_001289182.1,HGNC:HGNC:13848 zinc finger protein 302 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF304 264.137087307956 267.064211752273 261.20996286364 0.978079245997727 -0.0319767348465927 0.91596204566618 1 2.05381 1.70547 1.84529 1.86292 GeneID:57343,Genbank:XM_011527145.2,HGNC:HGNC:13505,MIM:613840 zinc finger protein 304 GO:0001525,GO:0003677,GO:0005634,GO:0006351,GO:0007229,GO:0007265,GO:0016569,GO:0030335,GO:0035562,GO:0045766,GO:0045944,GO:0046872,GO:0050679,GO:0090309,GO:1900114,GO:1902466,GO:1990841,GO:2000811 angiogenesis|DNA binding|nucleus|transcription, DNA-templated|integrin-mediated signaling pathway|Ras protein signal transduction|covalent chromatin modification|positive regulation of cell migration|negative regulation of chromatin binding|positive regulation of angiogenesis|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|positive regulation of epithelial cell proliferation|positive regulation of methylation-dependent chromatin silencing|positive regulation of histone H3-K9 trimethylation|positive regulation of histone H3-K27 trimethylation|promoter-specific chromatin binding|negative regulation of anoikis ZNF311 26.6093833315853 25.1082943585565 28.1104723046141 1.11956917117449 0.16294366604451 0.777339603743589 1 0.212714 0.0894111 0.196505 0.175842 GeneID:282890,Genbank:XM_017010759.1,HGNC:HGNC:13847 zinc finger protein 311 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF316 1523.70589382025 1429.29030642334 1618.12148121717 1.1321153400014 0.179020947543743 0.212269270761024 1 8.97193 8.3332 9.84004 10.2293 GeneID:100131017,Genbank:NM_001278559.1,HGNC:HGNC:13843 zinc finger protein 316 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF317 1021.0132837455 899.725396014717 1142.30117147629 1.26961090187745 0.344386421452871 0.0233767177967125 0.616997337836357 7.22034 7.19575 9.75371 8.68483 GeneID:57693,Genbank:NM_020933.4,HGNC:HGNC:13507,MIM:613864 zinc finger protein 317 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF318 943.993440455014 1054.87306567879 833.113815231239 0.789776364889123 -0.340483901016 0.0278526717490769 0.668561867500627 4.1214 4.05312 3.49882 2.97378 GeneID:24149,Genbank:NM_014345.2,HGNC:HGNC:13578,MIM:617512 zinc finger protein 318 GO:0003676,GO:0005654,GO:0005829,GO:0006351,GO:0008270,GO:0042803,GO:0045892,GO:0045893,GO:0051321 nucleic acid binding|nucleoplasm|cytosol|transcription, DNA-templated|zinc ion binding|protein homodimerization activity|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|meiotic cell cycle ZNF319 437.913472139566 454.211618368483 421.615325910649 0.928235449866037 -0.107437298942152 0.532809341225919 1 4.67703 5.12709 4.48335 4.64785 GeneID:57567,Genbank:NM_020807.2,HGNC:HGNC:13644 zinc finger protein 319 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF32 283.108682007911 265.297048244038 300.920315771783 1.13427690870868 0.181772885476692 0.453786684490227 1 5.12419 6.10308 5.91136 6.82536 GeneID:7580,Genbank:NM_006973.2,HGNC:HGNC:13095,MIM:194539 zinc finger protein 32 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF320 302.975854315808 293.334945358376 312.616763273239 1.06573310892538 0.0918461898430693 0.730855256104043 1 1.0807 0.800885 1.16527 0.849615 GeneID:162967,Genbank:XM_024451397.1,HGNC:HGNC:13842,MIM:606427 zinc finger protein 320 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF322 146.557137942259 154.013639380994 139.100636503523 0.903170894880419 -0.146929099573889 0.629438426185578 1 1.20681 0.943992 1.15865 0.906757 GeneID:79692,Genbank:NM_001242799.1,HGNC:HGNC:23640,MIM:610847 zinc finger protein 322 GO:0003677,GO:0003700,GO:0005634,GO:0005813,GO:0005829,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|centrosome|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF324 368.106600518481 370.324181740366 365.889019296595 0.988023567829333 -0.0173826393274334 0.916476400129472 1 3.54297 3.7345 3.63005 3.5522 GeneID:25799,Genbank:NM_014347.2,HGNC:HGNC:14096,MIM:617477 zinc finger protein 324 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF324B 146.661978778088 133.88351128202 159.440446274155 1.1908893391532 0.252039360076726 0.349631959449898 1 1.46412 1.97788 2.05757 2.03397 GeneID:388569,Genbank:NM_207395.2,HGNC:HGNC:33107 zinc finger protein 324B GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF326 498.890851684842 581.943698487411 415.838004882273 0.714567415994227 -0.484857965816287 0.00578822895151617 0.302955146691121 1.93471 1.903 1.51329 1.26257 GeneID:284695,Genbank:NM_181781.3,HGNC:HGNC:14104,MIM:614601 zinc finger protein 326 GO:0000993,GO:0003677,GO:0003723,GO:0005654,GO:0006351,GO:0006397,GO:0008380,GO:0016363,GO:0032784,GO:0043231,GO:0043484,GO:0044609,GO:0046872 RNA polymerase II core binding|DNA binding|RNA binding|nucleoplasm|transcription, DNA-templated|mRNA processing|RNA splicing|nuclear matrix|regulation of DNA-templated transcription, elongation|intracellular membrane-bounded organelle|regulation of RNA splicing|DBIRD complex|metal ion binding ZNF330 548.234416697762 613.307251211828 483.161582183695 0.787796950433932 -0.344104262604559 0.0475959843247169 0.802418194678596 11.7797 10.4934 8.70709 8.86465 GeneID:27309,Genbank:XM_017008033.1,HGNC:HGNC:15462,MIM:609550 zinc finger protein 330 GO:0000775,GO:0005730,GO:0008270,GO:0030496,GO:0046872 chromosome, centromeric region|nucleolus|zinc ion binding|midbody|metal ion binding ZNF331 250.179971720138 251.719127813286 248.64081562699 0.987770845175582 -0.0177517078083196 0.939599334742271 1 1.02316 1.06422 1.17591 0.840576 GeneID:55422,Genbank:XM_017026937.1,HGNC:HGNC:15489,MIM:606043 zinc finger protein 331 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding ZNF333 174.64149272221 168.033604939018 181.249380505403 1.07864959852037 0.109226278562646 0.648984954927666 1 0.46732 0.412872 0.501192 0.483944 GeneID:84449,Genbank:XM_011528362.2,HGNC:HGNC:15624,MIM:611811 zinc finger protein 333 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF335 692.666136677868 671.943331658187 713.388941697548 1.061680216302 0.086349284193972 0.613376736594715 1 3.51786 3.6069 3.9471 3.67236 GeneID:63925,Genbank:XM_005260504.4,HGNC:HGNC:15807,MIM:610827 zinc finger protein 335 GO:0000978,GO:0001701,GO:0002052,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0007420,GO:0021895,GO:0035097,GO:0040029,GO:0044212,GO:0046872,GO:0048812,GO:0048854,GO:0050671,GO:0050769,GO:0051569,GO:0080182 RNA polymerase II proximal promoter sequence-specific DNA binding|in utero embryonic development|positive regulation of neuroblast proliferation|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|brain development|cerebral cortex neuron differentiation|histone methyltransferase complex|regulation of gene expression, epigenetic|transcription regulatory region DNA binding|metal ion binding|neuron projection morphogenesis|brain morphogenesis|positive regulation of lymphocyte proliferation|positive regulation of neurogenesis|regulation of histone H3-K4 methylation|histone H3-K4 trimethylation ZNF337 210.37205217379 208.478191582308 212.265912765273 1.01816842881367 0.0259762365755809 0.913540616660189 1 0.731655 0.716093 0.779969 0.740564 GeneID:26152,Genbank:NM_015655.3,HGNC:HGNC:15809 zinc finger protein 337 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF33A 128.771457946582 128.127115972371 129.415799920794 1.01005785495633 0.0144379312623126 0.960241442997551 1 0.378785 0.344945 0.500285 0.2927 GeneID:7581,Genbank:XM_011519650.2,HGNC:HGNC:13096,MIM:194521 zinc finger protein 33A GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF33B 135.609237311476 133.114073886206 138.104400736747 1.03748910017438 0.053096179633569 0.827931695661944 1 0.55729 0.362099 0.525254 0.456419 GeneID:7582,Genbank:NM_001305033.1,HGNC:HGNC:13097,MIM:194522 zinc finger protein 33B GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF34 83.6511436584787 77.6507785716173 89.6515087453401 1.1545474545713 0.207327472434397 0.52111404447383 1 0.628667 0.512442 0.592816 0.801895 GeneID:80778,Genbank:NM_001286770.1,HGNC:HGNC:13098,MIM:194526 zinc finger protein 34 GO:0003677,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF341 111.654047804944 108.447824654922 114.860270954965 1.05912932159264 0.0828787557415335 0.777203629335448 1 1.13582 1.05088 1.2777 1.1397 GeneID:84905,Genbank:NM_001282933.1,HGNC:HGNC:15992 zinc finger protein 341 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF343 158.555632775569 149.440317629962 167.670947921176 1.1219927164258 0.166063310518466 0.518431994747047 1 0.830201 0.97076 0.902447 1.01483 GeneID:79175,Genbank:NM_001282495.1,HGNC:HGNC:16017 zinc finger protein 343 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF345 16.8126260441078 22.4756409051378 11.1496111830777 0.496075339080942 -1.01136885519345 0.147319354964992 1 0.179956 0.21488 0.118996 0.0704315 GeneID:25850,Genbank:XM_017026568.1,HGNC:HGNC:16367 zinc finger protein 345 GO:0000122,GO:0003677,GO:0003700,GO:0005634,GO:0006359,GO:0006366,GO:0006383,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|nucleus|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter|metal ion binding ZNF346 559.95291868101 521.887464111574 598.018373250447 1.14587610236715 0.196451061404062 0.247269659938504 1 1.48073 1.45904 1.74968 1.68086 GeneID:23567,Genbank:NM_001308213.1,HGNC:HGNC:16403,MIM:605308 zinc finger protein 346 GO:0002039,GO:0003723,GO:0003725,GO:0005634,GO:0005730,GO:0005737,GO:0008270,GO:0019899,GO:0035198,GO:0043065,GO:0072332 p53 binding|RNA binding|double-stranded RNA binding|nucleus|nucleolus|cytoplasm|zinc ion binding|enzyme binding|miRNA binding|positive regulation of apoptotic process|intrinsic apoptotic signaling pathway by p53 class mediator ZNF347 209.894726233936 210.390450915452 209.39900155242 0.995287574323272 -0.00681466259073785 0.991359003594584 1 0.827852 0.848253 1.06099 0.6618 GeneID:84671,Genbank:XM_005259335.4,HGNC:HGNC:16447 zinc finger protein 347 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF35 154.748623436949 143.261494503256 166.235752370642 1.16036589557471 0.214579798883393 0.392867137790058 1 1.73283 1.74529 2.0892 1.85899 GeneID:7584,Genbank:NM_003420.3,HGNC:HGNC:13099,MIM:194533 zinc finger protein 35 GO:0003677,GO:0003700,GO:0005623,GO:0005634,GO:0006351,GO:0006355,GO:0007283,GO:0043565,GO:0046872,GO:0048471,GO:0071300 DNA binding|DNA binding transcription factor activity|cell|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|spermatogenesis|sequence-specific DNA binding|metal ion binding|perinuclear region of cytoplasm|cellular response to retinoic acid ZNF350 53.0078793741939 50.2842323020138 55.7315264463741 1.10833006481322 0.148387585320003 0.725122422357842 1 0.291956 0.278082 0.32134 0.338148 GeneID:59348,Genbank:XM_017027094.1,HGNC:HGNC:16656,MIM:605422 zinc finger protein 350 GO:0000122,GO:0001162,GO:0001227,GO:0003677,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0016363,GO:0016604,GO:0017053,GO:0045892,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear matrix|nuclear body|transcriptional repressor complex|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF354A 80.7998530213846 78.7269739249019 82.8727321178673 1.05265994596617 0.074039459629404 0.827684087683983 1 0.843722 0.77551 0.929638 0.852723 GeneID:6940,Genbank:NM_001324339.1,HGNC:HGNC:11628,MIM:602444 zinc finger protein 354A GO:0000122,GO:0001666,GO:0001822,GO:0003677,GO:0003700,GO:0005634,GO:0005730,GO:0005829,GO:0006351,GO:0006357,GO:0007576,GO:0007605,GO:0046872,GO:0051593 negative regulation of transcription from RNA polymerase II promoter|response to hypoxia|kidney development|DNA binding|DNA binding transcription factor activity|nucleus|nucleolus|cytosol|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|nucleolar fragmentation|sensory perception of sound|metal ion binding|response to folic acid ZNF354B 37.2983383031932 44.0573829006229 30.5392937057636 0.693170853444674 -0.5287171017783 0.323096208658058 1 0.805635 0.462648 0.540481 0.323927 GeneID:117608,Genbank:NM_058230.2,HGNC:HGNC:17197 zinc finger protein 354B GO:0000122,GO:0003677,GO:0003682,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|chromatin binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF354C 8.62769958065982 9.98372448277907 7.27167467854057 0.728352899870532 -0.457290463786568 0.727200366729431 1 0.0962652 0.0200395 0.066603 0.0309264 GeneID:30832,Genbank:NM_014594.2,HGNC:HGNC:16736 zinc finger protein 354C GO:0003677,GO:0003700,GO:0005829,GO:0006351,GO:0006355,GO:0031965,GO:0046872 DNA binding|DNA binding transcription factor activity|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear membrane|metal ion binding ZNF358 1852.95050155838 1661.77422204816 2044.1267810686 1.23008694800259 0.298760295254548 0.0372837569394568 0.744556882325193 43.2691 44.2974 55.4707 55.539 GeneID:140467,Genbank:XM_005272460.3,HGNC:HGNC:16838 zinc finger protein 358 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0019827,GO:0021915,GO:0035115,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|stem cell population maintenance|neural tube development|embryonic forelimb morphogenesis|metal ion binding ZNF362 483.524416858856 457.728362076446 509.320471641267 1.11271337727638 0.154082018164947 0.396494033420349 1 3.87486 4.25554 4.50297 4.68607 GeneID:149076,Genbank:XM_005270507.2,HGNC:HGNC:18079 zinc finger protein 362 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF365 702.537329518198 711.512619701185 693.562039335212 0.974771241058926 -0.0368644074224504 0.82930371708813 1 3.08152 3.11281 3.38771 2.67298 GeneID:22891,Genbank:NM_199451.2,HGNC:HGNC:18194,MIM:607818 zinc finger protein 365 GO:0000723,GO:0005737,GO:0005815,GO:0010569,GO:0010977,GO:0021687,GO:0042802,GO:0043231,GO:0046872,GO:0048714,GO:0060997,GO:0110026,GO:0140059 telomere maintenance|cytoplasm|microtubule organizing center|regulation of double-strand break repair via homologous recombination|negative regulation of neuron projection development|cerebellar molecular layer morphogenesis|identical protein binding|intracellular membrane-bounded organelle|metal ion binding|positive regulation of oligodendrocyte differentiation|dendritic spine morphogenesis|regulation of DNA strand resection involved in replication fork processing|dendrite arborization ZNF366 1.75326998279533 1.56626675524197 1.94027321034868 1.23878847830677 0.308929870005269 1 1 0.0127683 0.00583554 0.0241179 0 GeneID:167465,Genbank:NM_152625.2,HGNC:HGNC:18316,MIM:610159 zinc finger protein 366 GO:0000122,GO:0003677,GO:0003714,GO:0005634,GO:0006351,GO:0030331,GO:0033147,GO:0043627,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|transcription corepressor activity|nucleus|transcription, DNA-templated|estrogen receptor binding|negative regulation of intracellular estrogen receptor signaling pathway|response to estrogen|metal ion binding ZNF367 618.72579546737 610.232552631137 627.219038303604 1.02783608576636 0.0396102089800518 0.881591082731785 1 5.53448 5.03688 6.68422 4.35978 GeneID:195828,Genbank:NM_153695.3,HGNC:HGNC:18320,MIM:610160 zinc finger protein 367 GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF37A 113.85070328014 119.123534293506 108.577872266774 0.911472891655905 -0.133728345540301 0.659212334202445 1 0.272345 0.274665 0.327285 0.195848 GeneID:7587,Genbank:XM_017016619.1,HGNC:HGNC:13102,MIM:616085 zinc finger protein 37A GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF382 43.575221114899 43.5290938790885 43.6213483507094 1.00211937496051 0.00305437620316665 1 1 0.410881 0.47557 0.52217 0.38923 GeneID:84911,Genbank:NM_032825.4,HGNC:HGNC:17409,MIM:609516 zinc finger protein 382 GO:0000122,GO:0003700,GO:0005634,GO:0006351,GO:0044212,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF383 88.605564583474 97.2340173396959 79.9771118272521 0.822521932297055 -0.281873946502296 0.381227510319745 1 0.610642 0.560602 0.63428 0.404981 GeneID:163087,Genbank:XM_011526587.3,HGNC:HGNC:18609 zinc finger protein 383 GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0031965,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear membrane|metal ion binding ZNF384 1046.6971602356 1033.51387174822 1059.88044872298 1.02551158498739 0.0363437897304475 0.836853179505262 1 5.35041 6.14053 6.26209 6.08636 GeneID:171017,Genbank:NM_001039920.2,HGNC:HGNC:11955,MIM:609951 zinc finger protein 384 ZNF385A 288.868642787704 266.603566315639 311.133719259769 1.16702759666542 0.222838676813558 0.273970077563633 1 2.94163 2.87757 3.51197 3.27087 GeneID:25946,Genbank:NM_001130968.2,HGNC:HGNC:17521,MIM:609124 zinc finger protein 385A GO:0002039,GO:0003677,GO:0003723,GO:0003730,GO:0005654,GO:0005730,GO:0005737,GO:0006351,GO:0006355,GO:0006915,GO:0006974,GO:0006977,GO:0007599,GO:0007611,GO:0007626,GO:0008270,GO:0010609,GO:0030220,GO:0030425,GO:0035855,GO:0043025,GO:0045600,GO:0070889,GO:1901796,GO:1902164,GO:1902166,GO:2000765 p53 binding|DNA binding|RNA binding|mRNA 3'-UTR binding|nucleoplasm|nucleolus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|cellular response to DNA damage stimulus|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|hemostasis|learning or memory|locomotory behavior|zinc ion binding|mRNA localization resulting in posttranscriptional regulation of gene expression|platelet formation|dendrite|megakaryocyte development|neuronal cell body|positive regulation of fat cell differentiation|platelet alpha granule organization|regulation of signal transduction by p53 class mediator|positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of cytoplasmic translation ZNF385B 28.5795763663389 30.018817033238 27.1403356994398 0.904110767236062 -0.145428559467478 0.795266756041182 1 0.0779851 0.103423 0.0786125 0.0599345 GeneID:151126,Genbank:XM_011510713.3,HGNC:HGNC:26332,MIM:612344 zinc finger protein 385B GO:0001650,GO:0002039,GO:0003723,GO:0005634,GO:0008270,GO:0072332 fibrillar center|p53 binding|RNA binding|nucleus|zinc ion binding|intrinsic apoptotic signaling pathway by p53 class mediator ZNF385C 4.17926473483438 2.54640955915669 5.81211991051207 2.28247647343772 1.19059998974743 0.491306381727974 1 0 0.0476448 0 0.0628373 GeneID:201181,Genbank:NM_001242704.1,HGNC:HGNC:33722 zinc finger protein 385C GO:0002039,GO:0003723,GO:0005634,GO:0008270,GO:0072332 p53 binding|RNA binding|nucleus|zinc ion binding|intrinsic apoptotic signaling pathway by p53 class mediator ZNF385D 162.287802136724 168.523676340975 156.051927932472 0.925994087719346 -0.110925112681775 0.668077340958219 1 0.228217 0.252507 0.217971 0.200585 GeneID:79750,Genbank:XM_017007192.1,HGNC:HGNC:26191 zinc finger protein 385D GO:0002039,GO:0003723,GO:0005634,GO:0008270,GO:0072332 p53 binding|RNA binding|nucleus|zinc ion binding|intrinsic apoptotic signaling pathway by p53 class mediator ZNF391 34.9266889980746 44.6533155070581 25.2000624890911 0.564349191161581 -0.8253399881691 0.0875743719031707 0.970036792388817 0.39198 0.354005 0.196496 0.192073 GeneID:346157,Genbank:NM_001322288.1,HGNC:HGNC:18779 zinc finger protein 391 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF394 410.780763883541 408.164523894706 413.397003872376 1.01281953641571 0.0183771384908861 0.937823708817531 1 4.80786 5.26455 5.40302 4.96728 GeneID:84124,Genbank:NM_001345968.1,HGNC:HGNC:18832 zinc finger protein 394 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF395 797.368660817436 769.465506645993 825.271814988879 1.07252606888922 0.101012714391605 0.533553504696579 1 6.79597 6.96656 7.1014 7.82353 GeneID:55893,Genbank:NM_018660.2,HGNC:HGNC:18737,MIM:609494 zinc finger protein 395 GO:0000978,GO:0001158,GO:0003677,GO:0005634,GO:0005737,GO:0005829,GO:0006351,GO:0006355,GO:0006357,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|enhancer sequence-specific DNA binding|DNA binding|nucleus|cytoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF396 12.4364248424063 10.819788462639 14.0530612221736 1.2988295723802 0.377212138089395 0.672593514807961 1 0.0797168 0.0675677 0.0765431 0.126842 GeneID:252884,Genbank:NM_145756.2,HGNC:HGNC:18824,MIM:609600 zinc finger protein 396 GO:0003677,GO:0003700,GO:0005634,GO:0005737,GO:0006351,GO:0042803,GO:0045892,GO:0046872,GO:0046982 DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|transcription, DNA-templated|protein homodimerization activity|negative regulation of transcription, DNA-templated|metal ion binding|protein heterodimerization activity ZNF397 89.5271916146934 84.0697330717479 94.9846501576388 1.12983170859572 0.176107895422917 0.58564940269366 1 0.238538 0.266366 0.313469 0.321773 GeneID:84307,Genbank:XM_024451275.1,HGNC:HGNC:18818,MIM:609601 zinc finger protein 397 GO:0003677,GO:0003700,GO:0005634,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006351,GO:0015630,GO:0042803,GO:0045892,GO:0046872,GO:0046982 DNA binding|DNA binding transcription factor activity|nucleus|nucleolus|cytoplasm|cytosol|plasma membrane|transcription, DNA-templated|microtubule cytoskeleton|protein homodimerization activity|negative regulation of transcription, DNA-templated|metal ion binding|protein heterodimerization activity ZNF398 365.701223361066 363.559234662333 367.843212059798 1.01178343716518 0.0169005276189245 0.947774838136541 1 2.04791 2.19051 2.25475 2.08257 GeneID:57541,Genbank:NM_020781.3,HGNC:HGNC:18373 zinc finger protein 398 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0045893,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding ZNF404 19.9823922125684 16.7006452861273 23.2641391390094 1.39300839820448 0.478203955721961 0.488530842065476 1 0.20693 0.384809 0.481829 0.278787 GeneID:342908,Genbank:NM_001033719.2,HGNC:HGNC:19417 zinc finger protein 404 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF407 91.7791741868745 102.13473135927 81.4236170144796 0.797217713610697 -0.326954328696347 0.294258983231374 1 0.164784 0.160745 0.145632 0.122158 GeneID:55628,Genbank:XM_005266726.5,HGNC:HGNC:19904,MIM:615894 zinc finger protein 407 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding ZNF408 375.124407388054 364.98142259352 385.267392182587 1.05558082777177 0.0780370527361078 0.694753788093137 1 5.61976 5.74857 5.62318 6.28233 GeneID:79797,Genbank:NM_024741.2,HGNC:HGNC:20041,MIM:616454 zinc finger protein 408 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0042802,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|identical protein binding|metal ion binding ZNF41 104.160346683132 101.192806174932 107.127887191333 1.05865121485159 0.0822273546882333 0.840767913617577 1 0.463135 0.362064 0.553241 0.305367 GeneID:7592,Genbank:XM_017029814.2,HGNC:HGNC:13107,MIM:314995 zinc finger protein 41 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF410 1199.14072975089 1204.66918454176 1193.61227496001 0.990821621633863 -0.0133027435784218 0.933492228123228 1 12.2622 12.272 12.3311 12.7497 GeneID:57862,Genbank:NM_001242924.1,HGNC:HGNC:20144 zinc finger protein 410 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF414 309.512373236656 312.256641936828 306.768104536485 0.98242299229794 -0.0255837694336943 0.883678071712617 1 9.21589 9.9029 9.30557 8.94081 GeneID:84330,Genbank:NM_001146175.1,HGNC:HGNC:20630 zinc finger protein 414 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF415 55.9549055357652 47.4496650947474 64.460145976783 1.35849527806085 0.442009550962878 0.263277547620588 1 0.29221 0.354894 0.490418 0.344565 GeneID:55786,Genbank:XM_024451600.1,HGNC:HGNC:20636 zinc finger protein 415 GO:0001650,GO:0003677,GO:0003700,GO:0005737,GO:0006351,GO:0006355,GO:0015630,GO:0046872 fibrillar center|DNA binding|DNA binding transcription factor activity|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|microtubule cytoskeleton|metal ion binding ZNF416 152.435986463911 147.383979472763 157.487993455059 1.06855571425362 0.0956621317524287 0.724442359399643 1 1.55396 1.7167 1.63255 1.97537 GeneID:55659,Genbank:XM_024451594.1,HGNC:HGNC:20645 zinc finger protein 416 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF417 173.240630221117 165.689109133709 180.792151308524 1.09115289625118 0.125853271421564 0.608577585609011 1 0.966891 0.959738 1.20221 0.846165 GeneID:147687,Genbank:XM_011526473.3,HGNC:HGNC:20646 zinc finger protein 417 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF418 50.756367195088 40.4445866432895 61.0681477468864 1.50992142126439 0.594473471337117 0.143486644676827 1 0.22303 0.196639 0.414439 0.292223 GeneID:147686,Genbank:XM_017026306.2,HGNC:HGNC:20647 zinc finger protein 418 GO:0003677,GO:0005634,GO:0006351,GO:0045892,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|negative regulation of transcription, DNA-templated|metal ion binding ZNF419 211.032222672775 196.716477935331 225.347967410219 1.14554698099211 0.19603662743738 0.371020239846812 1 2.83977 2.2568 3.08573 2.87909 GeneID:79744,Genbank:NM_001291744.1,HGNC:HGNC:20648,MIM:617410 zinc finger protein 419 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF420 34.0474694554449 39.0125900569944 29.0823488538953 0.745460601600872 -0.423795988357235 0.477369589113946 1 0.282981 0.172313 0.205867 0.129995 GeneID:147923,Genbank:XM_011526510.2,HGNC:HGNC:20649,MIM:617216 zinc finger protein 420 GO:0003677,GO:0003700,GO:0005654,GO:0006351,GO:0006355,GO:0042981,GO:0046872,GO:0070062 DNA binding|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of apoptotic process|metal ion binding|extracellular exosome ZNF423 32.4314202636804 24.637840266815 40.2250002605458 1.63265123180157 0.707216634200382 0.176983136277434 1 0.0407069 0.11598 0.152545 0.138657 GeneID:23090,Genbank:NM_001271620.2,HGNC:HGNC:16762,MIM:604557 zinc finger protein 423 GO:0003677,GO:0005634,GO:0005654,GO:0006351,GO:0007219,GO:0007399,GO:0030154,GO:0030513,GO:0045892,GO:0045893,GO:0046872 DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|Notch signaling pathway|nervous system development|cell differentiation|positive regulation of BMP signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding ZNF425 113.205797884721 117.86504249659 108.546553272851 0.920939330047684 -0.118821977791578 0.66585994119966 1 1.2176 1.43082 1.11636 1.2501 GeneID:155054,Genbank:NM_001001661.2,HGNC:HGNC:20690 zinc finger protein 425 GO:0003677,GO:0005634,GO:0005737,GO:0006351,GO:0045892,GO:0046872 DNA binding|nucleus|cytoplasm|transcription, DNA-templated|negative regulation of transcription, DNA-templated|metal ion binding ZNF426 256.55409559985 201.463304475742 311.644886723958 1.54690645790278 0.629385959036451 0.00250433064424935 0.182315270901352 0.958554 0.86004 1.65097 1.26855 GeneID:79088,Genbank:NM_001318055.1,HGNC:HGNC:20725 zinc finger protein 426 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF428 1857.50375686585 1831.90339976481 1883.10411396689 1.02794946185953 0.0397693375698278 0.8517387921907 1 56.7017 62.185 57.2061 67.1956 GeneID:126299,Genbank:NM_182498.3,HGNC:HGNC:20804 zinc finger protein 428 GO:0003676,GO:0046872 nucleic acid binding|metal ion binding ZNF429 36.8643024588935 29.6247981806506 44.1038067371364 1.48874623442812 0.574097859002065 0.229925983059303 1 0.0941911 0.101578 0.144159 0.147436 GeneID:353088,Genbank:XM_017026748.2,HGNC:HGNC:20817 zinc finger protein 429 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF43 127.643871079997 117.624911123165 137.662831036829 1.17035438940891 0.226945451540701 0.602127578407507 1 0.27888 0.407813 0.478729 0.310891 GeneID:7594,Genbank:NM_001256651.1,HGNC:HGNC:13109,MIM:603972 zinc finger protein 43 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF430 57.9933011706781 54.4351262359894 61.5514761053668 1.13073084167246 0.177255552141519 0.625917409343829 1 0.535438 0.360245 0.581187 0.45639 GeneID:80264,Genbank:NM_025189.3,HGNC:HGNC:20808 zinc finger protein 430 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0021762,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|substantia nigra development|metal ion binding ZNF431 67.4997949025998 68.599170618068 66.4004191871317 0.967947842355441 -0.0469987845801195 0.908970074511639 1 0.454309 0.477626 0.547876 0.416049 GeneID:170959,Genbank:NM_001319124.1,HGNC:HGNC:20809 zinc finger protein 431 GO:0000122,GO:0001046,GO:0003682,GO:0005634,GO:0006351,GO:0030154,GO:0043433,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|core promoter sequence-specific DNA binding|chromatin binding|nucleus|transcription, DNA-templated|cell differentiation|negative regulation of DNA binding transcription factor activity|metal ion binding ZNF432 68.0930968834308 70.7515613246372 65.4346324422243 0.924850720141473 -0.11270757541159 0.764262274890748 1 0.417192 0.460131 0.442846 0.316233 GeneID:9668,Genbank:XM_024451806.1,HGNC:HGNC:20810 zinc finger protein 432 GO:0003677,GO:0003700,GO:0005654,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF433 57.6228700640653 52.2347092547353 63.0110308733953 1.20630576435501 0.270595635934199 0.467132546128756 1 0.531244 0.398975 0.705646 0.494727 GeneID:163059,Genbank:NM_001308348.1,HGNC:HGNC:20811 zinc finger protein 433 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF436 1178.87830362485 1019.70359459744 1338.05301265226 1.31219799532088 0.39198542217862 0.00813262166423475 0.354981226562783 7.82781 7.37444 10.4043 9.98526 GeneID:80818,Genbank:NM_001077195.1,HGNC:HGNC:20814,MIM:611703 zinc finger protein 436 GO:0003677,GO:0003700,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF438 118.838736512911 125.234713835312 112.44275919051 0.897856159422191 -0.155443757615885 0.601827360066433 1 0.372238 0.334185 0.357602 0.286273 GeneID:220929,Genbank:XM_017015863.2,HGNC:HGNC:21029 zinc finger protein 438 GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0045892,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|metal ion binding ZNF439 40.2927165196189 38.9165375076246 41.6688955316132 1.07072463791131 0.098587504739648 0.849400533941904 1 0.412407 0.280034 0.312491 0.43612 GeneID:90594,Genbank:NM_001348721.1,HGNC:HGNC:20873 zinc finger protein 439 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF44 71.6755590397766 72.1061056709235 71.2450124086296 0.988057970205411 -0.0173324064434028 1 1 0.383179 0.190757 0.357311 0.270825 GeneID:51710,Genbank:XM_011528062.3,HGNC:HGNC:13110,MIM:194542 zinc finger protein 44 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF440 60.4706904076047 49.6981083506865 71.2432724645228 1.43352080851461 0.519562846415165 0.165082454149793 1 0.288536 0.369366 0.497751 0.443463 GeneID:126070,Genbank:XM_005259731.4,HGNC:HGNC:20874 zinc finger protein 440 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF441 11.3017749358644 11.4539386886512 11.1496111830777 0.973430318264672 -0.0388503856819552 1 1 0.0951718 0.0533131 0.0924305 0.042908 GeneID:126068,Genbank:NM_152355.2,HGNC:HGNC:20875 zinc finger protein 441 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF442 10.6588151027169 8.71542403075469 12.6022061746791 1.44596592549127 0.532033555259995 0.579141518257294 1 0.0787764 0.0559795 0.0850496 0.0879045 GeneID:79973,Genbank:NM_030824.2,HGNC:HGNC:20877 zinc finger protein 442 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF443 37.4574960732493 32.2672602891771 42.6477318573215 1.32170291109673 0.402397928090233 0.399238084010178 1 0.332157 0.40562 0.493101 0.492186 GeneID:10224,Genbank:NM_005815.4,HGNC:HGNC:20878,MIM:606697 zinc finger protein 443 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0006915,GO:0006950,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|apoptotic process|response to stress|metal ion binding ZNF444 547.352570140289 517.554273733967 577.150866546611 1.11515042158318 0.157238327038083 0.367998349639533 1 3.06935 3.37039 3.53055 3.91809 GeneID:55311,Genbank:XM_024451575.1,HGNC:HGNC:16052,MIM:607874 zinc finger protein 444 GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZNF445 638.314786657842 672.730352362507 603.899220953178 0.897683921696699 -0.155720539533255 0.352370267165501 1 2.52333 2.44131 2.54523 2.01316 GeneID:353274,Genbank:NM_181489.5,HGNC:HGNC:21018 zinc finger protein 445 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872,GO:0070062 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding|extracellular exosome ZNF446 254.08655104872 241.14927937918 267.023822718259 1.10729678896695 0.147041959774057 0.497778985544491 1 2.76922 2.55282 3.01134 3.14401 GeneID:55663,Genbank:XM_006723266.4,HGNC:HGNC:21036 zinc finger protein 446 GO:0000981,GO:0003677,GO:0005615,GO:0005634,GO:0006351,GO:0042802,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|extracellular space|nucleus|transcription, DNA-templated|identical protein binding|metal ion binding ZNF449 129.386572322233 120.641774774064 138.131369870402 1.14497130143429 0.19531143780055 0.470830954382772 1 0.807591 0.727749 1.03738 0.835847 GeneID:203523,Genbank:XM_011531314.3,HGNC:HGNC:21039,MIM:300627 zinc finger protein 449 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0007284,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|spermatogonial cell division|metal ion binding ZNF45 384.601341803608 327.159680748542 442.043002858674 1.35115366859168 0.434191763714468 0.0763910544377586 0.94157495521624 2.22324 2.18707 3.61666 2.529 GeneID:7596,Genbank:NM_003425.3,HGNC:HGNC:13111,MIM:194554 zinc finger protein 45 GO:0003677,GO:0003700,GO:0005654,GO:0006355,GO:0006367,GO:0007275,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleoplasm|regulation of transcription, DNA-templated|transcription initiation from RNA polymerase II promoter|multicellular organism development|metal ion binding ZNF451 377.239682488886 400.168476983371 354.310887994401 0.885404294374553 -0.175591724096889 0.566933745950617 1 1.09273 0.875599 1.02985 0.72028 GeneID:26036,Genbank:NM_001257273.1,HGNC:HGNC:21091,MIM:615708 zinc finger protein 451 GO:0001106,GO:0003676,GO:0005634,GO:0006351,GO:0016605,GO:0016874,GO:0016925,GO:0030512,GO:0046872,GO:0060633,GO:0061665,GO:2000616 RNA polymerase II transcription corepressor activity|nucleic acid binding|nucleus|transcription, DNA-templated|PML body|ligase activity|protein sumoylation|negative regulation of transforming growth factor beta receptor signaling pathway|metal ion binding|negative regulation of transcription initiation from RNA polymerase II promoter|SUMO ligase activity|negative regulation of histone H3-K9 acetylation ZNF460 33.0469858430881 28.2986627988333 37.795308887343 1.3355863899301 0.417473297045865 0.403726488920219 1 0.244218 0.238447 0.282132 0.408031 GeneID:10794,Genbank:NM_001330622.1,HGNC:HGNC:21628,MIM:604755 zinc finger protein 460 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF461 68.1547680701177 60.2199305101079 76.0896056301275 1.26352861894047 0.337458341715131 0.336058308959403 1 0.41514 0.350605 0.576035 0.395782 GeneID:92283,Genbank:NM_001322826.1,HGNC:HGNC:21629,MIM:608640 zinc finger protein 461 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF462 515.737622832543 491.01296578826 540.462279876826 1.10070877458232 0.138432811279648 0.655850994158939 1 1.20401 1.07074 1.58119 0.986398 GeneID:58499,Genbank:XM_006717212.4,HGNC:HGNC:21684,MIM:617371 zinc finger protein 462 GO:0003677,GO:0005634,GO:0006325,GO:0006351,GO:0043392,GO:0045944,GO:0046872 DNA binding|nucleus|chromatin organization|transcription, DNA-templated|negative regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF467 13.5912942847202 14.5864721991351 12.5961163703053 0.863547826941469 -0.211652012349728 0.853840772081559 1 0.204705 0.103481 0.0991848 0.175013 GeneID:168544,Genbank:XM_011515858.1,HGNC:HGNC:23154,MIM:614040 zinc finger protein 467 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF468 157.062141496826 139.638889590815 174.485393402838 1.2495472709224 0.32140548024442 0.19680327392301 1 1.04529 1.0521 1.52558 1.09455 GeneID:90333,Genbank:NM_001008801.1,HGNC:HGNC:33105,MIM:616841 zinc finger protein 468 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF469 29.3828209132569 36.4759891529457 22.2896526735681 0.611077401632796 -0.710572965449921 0.179160737117429 1 0.106923 0.0902996 0.0529372 0.0708633 GeneID:84627,Genbank:XM_017023785.1,HGNC:HGNC:23216,MIM:612078 zinc finger protein 469 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF470 100.851854535596 84.4059169945425 117.297792076649 1.3896868401327 0.474759814539673 0.107090445789003 1 0.417366 0.40424 0.686861 0.472223 GeneID:388566,Genbank:XM_017026801.1,HGNC:HGNC:22220 zinc finger protein 470 GO:0003677,GO:0003700,GO:0005654,GO:0006351,GO:0006355,GO:0016604,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear body|metal ion binding ZNF471 41.3283758209527 35.6399251730858 47.0168264688196 1.31921787827785 0.39968285568306 0.364130032701629 1 0.130633 0.113133 0.202358 0.138132 GeneID:57573,Genbank:NM_020813.3,HGNC:HGNC:23226 zinc finger protein 471 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF473 459.925520299086 463.791515343566 456.059525254605 0.983328737518552 -0.0242542890005977 0.884047986878434 1 3.00728 3.31738 3.38922 2.86313 GeneID:25888,Genbank:NM_015428.3,HGNC:HGNC:23239,MIM:617908 zinc finger protein 473 GO:0003677,GO:0005654,GO:0006355,GO:0006369,GO:0006398,GO:0008334,GO:0015030,GO:0046872 DNA binding|nucleoplasm|regulation of transcription, DNA-templated|termination of RNA polymerase II transcription|mRNA 3'-end processing by stem-loop binding and cleavage|histone mRNA metabolic process|Cajal body|metal ion binding ZNF48 370.981527568713 351.394710508516 390.56834462891 1.11148043197265 0.15248254940447 0.587103503720498 1 3.48668 4.21745 3.87796 4.68683 GeneID:197407,Genbank:NM_001214906.1,HGNC:HGNC:13114 zinc finger protein 48 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF480 219.398258582908 207.622510292232 231.174006873585 1.11343421552993 0.155016322622913 0.459970767031921 1 0.898422 0.673431 0.880743 0.811266 GeneID:147657,Genbank:NM_144684.3,HGNC:HGNC:23305,MIM:613910 zinc finger protein 480 GO:0003964,GO:0006310,GO:0009036,GO:0032197,GO:0032199,GO:0046872,GO:0090305 RNA-directed DNA polymerase activity|DNA recombination|Type II site-specific deoxyribonuclease activity|transposition, RNA-mediated|reverse transcription involved in RNA-mediated transposition|metal ion binding|nucleic acid phosphodiester bond hydrolysis ZNF483 37.4483727527571 35.1498537711284 39.7468917343858 1.13078398542396 0.177323356452007 0.707870057459578 1 0.0918115 0.0659625 0.109021 0.0708182 GeneID:158399,Genbank:NM_001007169.4,HGNC:HGNC:23384 zinc finger protein 483 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF484 21.1769358093122 22.4756409051378 19.8782307134866 0.884434432699204 -0.177172901803118 0.817403269680847 1 0.123444 0.158018 0.202306 0.0556178 GeneID:83744,Genbank:NM_001007101.3,HGNC:HGNC:23385 zinc finger protein 484 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF485 30.2135086523613 27.9526702209308 32.4743470837919 1.16176189348363 0.216314414447962 0.68046019292348 1 0.203662 0.118465 0.217031 0.168978 GeneID:220992,Genbank:NM_001318140.1,HGNC:HGNC:23440 zinc finger protein 485 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF486 93.4862461213261 76.9489847607043 110.023507481948 1.42982402983092 0.515837603708724 0.187777500597472 1 0.857917 0.499863 1.14769 0.821699 GeneID:90649,Genbank:NM_052852.3,HGNC:HGNC:20807 zinc finger protein 486 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872,GO:0070062 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding|extracellular exosome ZNF487 16.5968008119383 18.6511222388488 14.5424793850277 0.779710689726589 -0.358989181069417 0.651202062498517 1 0.188737 0.0840536 0.170739 0.0708341 GeneID:642819,Genbank:XM_024448128.1,HGNC:HGNC:23488 zinc finger protein 487 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF488 73.8588316915485 69.6851746264605 78.0324887566364 1.1197860832655 0.163223155418396 0.671407229128198 1 0.415499 0.597558 0.664598 0.51816 GeneID:118738,Genbank:XM_006717617.3,HGNC:HGNC:23535 zinc finger protein 488 GO:0003677,GO:0005634,GO:0006351,GO:0014003,GO:0045892,GO:0046872,GO:0048714 DNA binding|nucleus|transcription, DNA-templated|oligodendrocyte development|negative regulation of transcription, DNA-templated|metal ion binding|positive regulation of oligodendrocyte differentiation ZNF490 90.308258428656 85.1459284250325 95.4705884322794 1.12125841127374 0.165118807759826 0.607113457159732 1 0.50761 0.53514 0.574133 0.577479 GeneID:57474,Genbank:NM_020714.2,HGNC:HGNC:23705 zinc finger protein 490 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF491 17.1622702414667 15.422536178995 18.9020043039385 1.22560933458418 0.29349919038711 0.697935838954877 1 0.146012 0.129982 0.187606 0.148433 GeneID:126069,Genbank:XM_005259730.4,HGNC:HGNC:23706 zinc finger protein 491 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF492 4.60587848416433 5.3329504917381 3.87880647659057 0.727328424030877 -0.459321136892189 0.878590694766443 1 0.0862663 0.00937874 0.0557218 0.0172456 GeneID:57615,Genbank:NM_020855.2,HGNC:HGNC:23707 zinc finger protein 492 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF493 18.8090464901251 14.8364122276678 22.7816807525824 1.53552492361313 0.618731929364421 0.360939356154873 1 0.0604195 0.0835686 0.147134 0.0818494 GeneID:284443,Genbank:NM_001076678.2,HGNC:HGNC:23708 zinc finger protein 493 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF496 1342.49625194556 1387.64607991378 1297.34642397734 0.934926018065032 -0.0970758877411623 0.497633308929104 1 4.26833 4.51881 4.1606 4.07833 GeneID:84838,Genbank:XM_017002591.1,HGNC:HGNC:23713,MIM:613911 zinc finger protein 496 GO:0000122,GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0016604,GO:0043621,GO:0045893,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|nuclear body|protein self-association|positive regulation of transcription, DNA-templated|metal ion binding ZNF497 30.5877333605445 25.8002795143615 35.3751872067275 1.37111643255788 0.455351087194105 0.376086174475384 1 0.374047 0.323196 0.440635 0.39748 GeneID:162968,Genbank:NM_001207009.1,HGNC:HGNC:23714 zinc finger protein 497 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF500 256.583554895558 252.901184371049 260.265925420068 1.02912102237613 0.0414126499823989 0.864163650554332 1 1.35314 1.42973 1.6555 1.362 GeneID:26048,Genbank:XM_011522453.2,HGNC:HGNC:23716 zinc finger protein 500 GO:0000122,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|metal ion binding ZNF501 21.0228282856633 16.8447241101821 25.2009324611445 1.49607273448375 0.581180316354016 0.365776054175437 1 0.158187 0.187967 0.282056 0.284108 GeneID:115560,Genbank:NM_001258280.1,HGNC:HGNC:23717 zinc finger protein 501 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF503 1489.80116785801 1374.9992590114 1604.60307670463 1.16698468467416 0.222785627463748 0.1227217414853 1 24.931 23.0178 28.7506 27.6177 GeneID:84858,Genbank:NM_032772.5,HGNC:HGNC:23589,MIM:613902 zinc finger protein 503 GO:0003676,GO:0005634,GO:0006351,GO:0006355,GO:0008285,GO:0010629,GO:0046872,GO:0061351,GO:0070315 nucleic acid binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of cell proliferation|negative regulation of gene expression|metal ion binding|neural precursor cell proliferation|G1 to G0 transition involved in cell differentiation ZNF506 59.2187693679483 47.1899164111068 71.2476223247898 1.50980607179081 0.594363253369458 0.104901986068335 1 0.548894 0.312487 0.79843 0.482801 GeneID:440515,Genbank:NM_001145404.1,HGNC:HGNC:23780 zinc finger protein 506 GO:0003677,GO:0005730,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF507 229.027370550804 269.014688704994 189.040052396613 0.702712752625628 -0.508993014480143 0.138551551557106 1 1.49934 1.15795 1.148 0.729637 GeneID:22847,Genbank:NM_001136156.1,HGNC:HGNC:23783 zinc finger protein 507 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF510 163.202758729973 175.172953559423 151.232563900522 0.863332842356972 -0.212011223268048 0.508764965101004 1 0.802506 0.708133 0.807357 0.512949 GeneID:22869,Genbank:NM_001314060.1,HGNC:HGNC:29161 zinc finger protein 510 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF511 858.392373498814 912.352599606877 804.432147390752 0.881711903640514 -0.181620757795524 0.239127525612065 1 37.5712 38.8584 33.0338 36.2594 GeneID:118472,Genbank:NM_145806.3,HGNC:HGNC:28445 zinc finger protein 511 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF512B 1674.69050977166 1597.52684211706 1751.85417742626 1.09660390751537 0.133042519494207 0.357181354538954 1 7.10054 6.93529 7.90733 8.00956 GeneID:57473,Genbank:XM_024451951.1,HGNC:HGNC:29212,MIM:617886 zinc finger protein 512B GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF513 381.249366645929 348.645370194657 413.853363097201 1.18703243604278 0.247359357624059 0.179649127375859 1 4.97736 4.53964 5.58096 6.18898 GeneID:130557,Genbank:XM_005264142.2,HGNC:HGNC:26498,MIM:613598 zinc finger protein 513 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0007601,GO:0044212,GO:0046872,GO:0050896,GO:0060041 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|visual perception|transcription regulatory region DNA binding|metal ion binding|response to stimulus|retina development in camera-type eye ZNF514 209.739291251353 201.37706058148 218.101521921227 1.08305047899425 0.115100485880234 0.608644368802529 1 1.04711 0.977935 1.26054 0.969854 GeneID:84874,Genbank:XM_006712806.2,HGNC:HGNC:25894 zinc finger protein 514 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF516 286.924311200875 261.250998513685 312.597623888065 1.19654135550295 0.258870260936548 0.196210592754907 1 1.2735 1.08309 1.51046 1.32735 GeneID:9658,Genbank:NM_014643.3,HGNC:HGNC:28990,MIM:615114 zinc finger protein 516 GO:0000987,GO:0003700,GO:0005634,GO:0006366,GO:0007165,GO:0007275,GO:0009409,GO:0033613,GO:0043565,GO:0044212,GO:0045893,GO:0046872,GO:0050873,GO:0060612 proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription from RNA polymerase II promoter|signal transduction|multicellular organism development|response to cold|activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|positive regulation of transcription, DNA-templated|metal ion binding|brown fat cell differentiation|adipose tissue development hsa04714 Thermogenesis ZNF517 91.4105541923855 86.8758913145452 95.9452170702258 1.10439404555683 0.143255014635147 0.733446513700515 1 0.307933 0.459635 0.415855 0.514653 GeneID:340385,Genbank:NM_213605.2,HGNC:HGNC:27984 zinc finger protein 517 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF518A 38.9852966517348 36.7641468010553 41.2064465024143 1.12083238937647 0.164570551921382 0.788830905059211 1 0.126347 0.0946856 0.164625 0.0691396 GeneID:9849,Genbank:XM_024448266.1,HGNC:HGNC:29009,MIM:617733 zinc finger protein 518A GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZNF518B 201.05784272118 210.658991253346 191.456694189015 0.908846534628861 -0.137891389490704 0.678030434296369 1 0.890062 0.688638 0.883481 0.592771 GeneID:85460,Genbank:XM_024454265.1,HGNC:HGNC:29365,MIM:617734 zinc finger protein 518B GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZNF519 43.9076450517621 52.436623008583 35.3786670949411 0.674693850691915 -0.567695082030331 0.192554002605093 1 0.122522 0.111434 0.0815864 0.078195 GeneID:162655,Genbank:XM_017025564.1,HGNC:HGNC:30574 zinc finger protein 519 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF521 7.98517473353894 7.24520982488261 8.72513964219528 1.20426321018752 0.268150749681579 0.843687122359448 1 0.0352883 0.0250374 0.0464941 0.0275612 GeneID:25925,Genbank:NM_001308225.1,HGNC:HGNC:24605,MIM:610974 zinc finger protein 521 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0019904,GO:0046872,GO:0048663 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|protein domain specific binding|metal ion binding|neuron fate commitment ZNF524 368.710451155631 344.8600861488 392.560816162462 1.13831908048959 0.186905013985381 0.333203010997308 1 12.3686 12.2129 14.6587 13.3421 GeneID:147807,Genbank:XM_011526487.2,HGNC:HGNC:28322 zinc finger protein 524 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF525 34.1979484856943 28.6446553767358 39.7512415946528 1.38773677224748 0.472733941556413 0.412003616512894 1 0.135794 0.148064 0.291048 0.132114 GeneID:170958,Genbank:NM_001348156.1,HGNC:HGNC:29423 zinc finger protein 525 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF526 331.440217426926 301.369209889288 361.511224964563 1.19956257342072 0.2625084156632 0.17911737862122 1 3.75243 3.72124 4.21824 4.68181 GeneID:116115,Genbank:NM_133444.2,HGNC:HGNC:29415,MIM:614387 zinc finger protein 526 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF527 60.8779089663052 68.4452831389052 53.3105347937053 0.778878139571941 -0.360530467739851 0.34204527247413 1 0.488945 0.426421 0.388606 0.354281 GeneID:84503,Genbank:XM_005259328.5,HGNC:HGNC:29385 zinc finger protein 527 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF528 147.294232651558 124.95636484231 169.632100460806 1.35753069221304 0.440984816079718 0.0860209997779046 0.964561165794104 0.746966 0.751391 1.01177 0.797167 GeneID:84436,Genbank:XM_017027363.2,HGNC:HGNC:29384,MIM:615580 zinc finger protein 528 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF529 123.909400399122 133.421848844532 114.396951953713 0.857407935390047 -0.22194632539414 0.482366515309045 1 0.619981 0.623653 0.666349 0.375331 GeneID:57711,Genbank:XM_011527169.2,HGNC:HGNC:29328 zinc finger protein 529 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF530 318.710184216101 286.53279766162 350.887570770582 1.2245982785711 0.292308560196359 0.138759574307259 1 1.83706 1.95778 2.66663 2.29207 GeneID:348327,Genbank:XM_011526921.2,HGNC:HGNC:29297 zinc finger protein 530 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF532 504.998350213546 529.708989232676 480.287711194415 0.906701077303122 -0.141301095812611 0.42666297369541 1 2.23306 2.15169 2.10899 1.84412 GeneID:55205,Genbank:NM_018181.5,HGNC:HGNC:30940 zinc finger protein 532 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF534 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00577896 0 GeneID:147658,Genbank:NM_001291368.2,HGNC:HGNC:26337 zinc finger protein 534 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF536 201.624109517256 186.636700903182 216.611518131329 1.16060516009494 0.214877248295508 0.34016488753272 1 0.373034 0.315114 0.376328 0.447301 GeneID:9745,Genbank:XM_011527555.2,HGNC:HGNC:29025 zinc finger protein 536 GO:0000122,GO:0000978,GO:0001078,GO:0005634,GO:0006351,GO:0007165,GO:0007275,GO:0044323,GO:0045665,GO:0046872,GO:0048387 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|transcription, DNA-templated|signal transduction|multicellular organism development|retinoic acid-responsive element binding|negative regulation of neuron differentiation|metal ion binding|negative regulation of retinoic acid receptor signaling pathway ZNF540 5.4752860601502 4.65077399104097 6.29979812925943 1.35456982889194 0.437834767256731 0.788138165330075 1 0.045427 0.0329455 0.0549569 0.0612581 GeneID:163255,Genbank:NM_152606.4,HGNC:HGNC:25331,MIM:613903 zinc finger protein 540 GO:0000900,GO:0003677,GO:0003700,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006351,GO:0017148,GO:0043231,GO:0045892,GO:0046872 translation repressor activity, nucleic acid binding|DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytoplasm|cytosol|transcription, DNA-templated|negative regulation of translation|intracellular membrane-bounded organelle|negative regulation of transcription, DNA-templated|metal ion binding ZNF541 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0 0 0 0 GeneID:84215,Genbank:XM_011527369.2,HGNC:HGNC:25294 zinc finger protein 541 GO:0000118,GO:0003700,GO:0005634,GO:0005667,GO:0006351,GO:0006357,GO:0007275,GO:0007283,GO:0008134,GO:0030154,GO:0044212,GO:0046872 histone deacetylase complex|DNA binding transcription factor activity|nucleus|transcription factor complex|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|multicellular organism development|spermatogenesis|transcription factor binding|cell differentiation|transcription regulatory region DNA binding|metal ion binding ZNF543 88.3187752582121 89.402683563486 87.2348669529383 0.975752219909502 -0.0354132549799515 0.935609603623241 1 0.885546 0.841446 0.863585 0.813603 GeneID:125919,Genbank:NM_213598.3,HGNC:HGNC:25281,MIM:616847 zinc finger protein 543 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF544 697.650223567652 595.17562634026 800.124820795045 1.34435078552363 0.426909634027064 0.00838235874238464 0.356525902221039 1.77465 1.64324 2.52308 2.34157 GeneID:27300,Genbank:XM_024451453.1,HGNC:HGNC:16759 zinc finger protein 544 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF546 8.80069586961109 10.3297170606816 7.27167467854057 0.703956810803562 -0.506441175614094 0.65122215759497 1 0.0470101 0.0369721 0.0329856 0.0115061 GeneID:339327,Genbank:XM_011526898.3,HGNC:HGNC:28671 zinc finger protein 546 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF547 52.3386248985049 52.3307618041052 52.3464879929047 1.00030051518949 0.000433486642185744 0.997707646352227 1 0.777645 0.496557 0.770304 0.545573 GeneID:284306,Genbank:NM_173631.3,HGNC:HGNC:26432 zinc finger protein 547 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF548 205.278164019665 194.391599440238 216.164728599092 1.11200653331497 0.153165264278527 0.515433362909105 1 1.16406 1.38966 1.56094 1.22684 GeneID:147694,Genbank:NM_001172773.1,HGNC:HGNC:26561 zinc finger protein 548 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF549 152.279911419703 144.616038849542 159.943783989863 1.10598924754306 0.145337359721162 0.555695649996475 1 1.44854 1.05306 1.62208 1.20741 GeneID:256051,Genbank:NM_001199295.1,HGNC:HGNC:26632 zinc finger protein 549 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF550 148.621316962724 158.626195752458 138.616438172989 0.87385590706156 -0.194532686220934 0.463623852386124 1 0.944613 0.753221 0.874349 0.686755 GeneID:162972,Genbank:XM_011526568.2,HGNC:HGNC:28643 zinc finger protein 550 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF551 198.32438790435 186.300516980387 210.348258828313 1.12908038172786 0.175148198415704 0.447063437305496 1 1.69921 1.67095 2.20189 1.69548 GeneID:90233,Genbank:NM_138347.4,HGNC:HGNC:25108 zinc finger protein 551 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF552 92.584640810963 90.190721268661 94.978560353265 1.0530857167706 0.0746228704822374 0.828417825165485 1 0.904624 1.03827 0.886077 1.09291 GeneID:79818,Genbank:XM_005259267.4,HGNC:HGNC:26135 zinc finger protein 552 GO:0003677,GO:0005634,GO:0006351,GO:0045892,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|negative regulation of transcription, DNA-templated|metal ion binding ZNF554 64.5638133315292 59.345648910671 69.7819777523875 1.17585668087353 0.23371222820717 0.534933364840369 1 0.352821 0.387304 0.408724 0.45036 GeneID:115196,Genbank:NM_001102651.1,HGNC:HGNC:26629 zinc finger protein 554 GO:0003677,GO:0005634,GO:0005730,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF555 91.0098165885843 92.8331833771876 89.1864497999811 0.960717348640415 -0.0578160548301185 0.868465640625351 1 0.361701 0.39107 0.418603 0.279773 GeneID:148254,Genbank:NM_152791.4,HGNC:HGNC:28382 zinc finger protein 555 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF556 0.514084539299833 1.02816907859967 0 0 -Inf 0.751642012251311 1 0.0232935 0.0217073 0 0 GeneID:80032,Genbank:NM_024967.2,HGNC:HGNC:25669 zinc finger protein 556 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF557 145.59090151372 144.827761258498 146.354041768942 1.01053859078661 0.0151244168917077 0.96227853518115 1 0.927083 0.878485 0.886495 0.930456 GeneID:79230,Genbank:NM_024341.2,HGNC:HGNC:28632 zinc finger protein 557 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF558 230.705613586284 223.448873978922 237.962353193645 1.06495212509369 0.0907885755756312 0.665484322656161 1 1.49375 1.34603 1.67446 1.48996 GeneID:148156,Genbank:NM_144693.2,HGNC:HGNC:26422 zinc finger protein 558 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF559 104.413469458172 87.6825293290813 121.144409587264 1.38162539920121 0.466366510102235 0.105622390852432 1 0.98381 0.823351 1.12799 1.35841 GeneID:84527,Genbank:NM_001202411.1,HGNC:HGNC:28197 zinc finger protein 559 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF559-ZNF177 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0.201101 6.91033e-06 6.19595e-06 2.80142e-06 GeneID:100529215,Genbank:NM_001172650.2,HGNC:HGNC:42964 ZNF559-ZNF177 readthrough GO:0000122,GO:0003677,GO:0005634,GO:0006351,GO:0046872,GO:0072562 negative regulation of transcription from RNA polymerase II promoter|DNA binding|nucleus|transcription, DNA-templated|metal ion binding|blood microparticle ZNF56 8.04614374267607 9.7916193840393 6.30066810131283 0.643475594198764 -0.636042664073289 0.575509823409049 1 0.0797215 0.0190179 0.038327 0.0533494 GeneID:7608,Genbank:NM_001355194.1,HGNC:HGNC:13124 zinc finger protein 56 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF560 1.22267695520831 1.96028560782945 0.48506830258717 0.247447770187054 -2.01480405310505 0.637703537798371 1 0 0.032363 0 0 GeneID:147741,Genbank:XM_011527697.2,HGNC:HGNC:26484 zinc finger protein 560 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF561 662.988627925493 667.790403722502 658.186852128484 0.985618913448765 -0.0208981541174004 0.945285128359906 1 4.02152 3.54572 4.30979 3.24623 GeneID:93134,Genbank:NM_001330365.1,HGNC:HGNC:28684 zinc finger protein 561 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF562 542.844910083536 518.639260741504 567.050559425567 1.09334291163158 0.128745952996763 0.44404623494135 1 3.06127 2.95826 3.5693 3.07299 GeneID:54811,Genbank:XM_005259941.4,HGNC:HGNC:25950 zinc finger protein 562 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF563 20.134954024207 17.9689457381517 22.3009623102623 1.24108351348142 0.311600198813678 0.663431231279796 1 0.139976 0.144769 0.314056 0.114561 GeneID:147837,Genbank:NM_145276.2,HGNC:HGNC:30498 zinc finger protein 563 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF564 74.6672993823228 82.4456313867131 66.8889673779324 0.811310026412294 -0.3016747771178 0.388433753697981 1 0.915388 0.790339 0.872088 0.590982 GeneID:163050,Genbank:NM_144976.3,HGNC:HGNC:31106 zinc finger protein 564 GO:0000122,GO:0003700,GO:0005634,GO:0006351,GO:0044212,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF565 40.9239364930422 31.9310763663825 49.9167966197019 1.56326695808648 0.644564167474261 0.161662956656672 1 0.184428 0.421924 0.503783 0.501986 GeneID:147929,Genbank:NM_001042474.2,HGNC:HGNC:26726,MIM:614275 zinc finger protein 565 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF566 68.9783372077469 64.2845805498216 73.6720938656722 1.14603056029237 0.196645515817683 0.579575416812839 1 0.455519 0.364902 0.564813 0.388042 GeneID:84924,Genbank:XM_011527428.1,HGNC:HGNC:25919 zinc finger protein 566 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF567 61.483672173728 64.3227981693986 58.6445461780573 0.911722559451049 -0.133333221153658 0.779476796638772 1 0.390327 0.266513 0.328641 0.228178 GeneID:163081,Genbank:XM_017026417.1,HGNC:HGNC:28696 zinc finger protein 567 GO:0000122,GO:0003700,GO:0005634,GO:0006351,GO:0044212,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF568 70.1104855646037 63.1603589218521 77.0606122073552 1.22007875703654 0.286974277885515 0.413899541983005 1 0.201994 0.198789 0.252771 0.23067 GeneID:374900,Genbank:NM_001204838.1,HGNC:HGNC:25392,MIM:617566 zinc finger protein 568 GO:0000122,GO:0000976,GO:0001701,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0045892,GO:0046872,GO:0060669 negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|in utero embryonic development|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|metal ion binding|embryonic placenta morphogenesis ZNF569 44.6801919509661 42.3470373213261 47.013346580606 1.11019210680247 0.150809341035581 0.728323634999005 1 0.284337 0.16128 0.311938 0.256226 GeneID:148266,Genbank:NM_001330482.1,HGNC:HGNC:24737,MIM:613904 zinc finger protein 569 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF57 50.1995035459395 50.9664088027109 49.4325982891681 0.969905462252988 -0.044083961799529 0.950399025551032 1 0.64675 0.582095 0.605853 0.563533 GeneID:126295,Genbank:NM_173480.2,HGNC:HGNC:13125 zinc finger protein 57 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF570 52.31917656297 46.9595936927901 57.67875943315 1.22826359636935 0.296620209213966 0.476868353874957 1 0.247315 0.301792 0.392916 0.299463 GeneID:148268,Genbank:XM_011526544.2,HGNC:HGNC:26416 zinc finger protein 570 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF571 17.9010883918877 22.7157722785625 13.0864045052128 0.576093312819604 -0.795625583499638 0.249783489373325 1 0.229115 0.181577 0.14148 0.112566 GeneID:51276,Genbank:XM_017026860.1,HGNC:HGNC:25000 zinc finger protein 571 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF572 3.75146730009424 4.11267631439867 3.39025828578981 0.82434357255891 -0.278682341072296 0.953533290095102 1 0.0347497 0.0447705 0.0111821 0.0623943 GeneID:137209,Genbank:NM_152412.2,HGNC:HGNC:26758 zinc finger protein 572 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF573 26.6500469393289 27.1264148961788 26.173678982479 0.964877927387523 -0.0515816651416498 0.957406525323093 1 0.136789 0.13038 0.121566 0.0941345 GeneID:126231,Genbank:XM_017026278.1,HGNC:HGNC:26420 zinc finger protein 573 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF574 477.817135978793 483.13462273822 472.499649219365 0.97798755663881 -0.032111985629778 0.846482047113083 1 4.82009 5.15981 5.09689 5.13171 GeneID:64763,Genbank:NM_001330519.1,HGNC:HGNC:26166 zinc finger protein 574 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF575 32.8718371248571 31.3351437599474 34.4085304897668 1.09808114343959 0.134984667196005 0.810063221568869 1 0.797847 0.705832 0.871971 0.94794 GeneID:284346,Genbank:XM_011526793.3,HGNC:HGNC:27606 zinc finger protein 575 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF576 449.554271803937 415.947831396231 483.160712211642 1.1615896892401 0.216100552533599 0.232535287127396 1 7.76905 7.77039 8.77237 9.02239 GeneID:79177,Genbank:NM_024327.2,HGNC:HGNC:28357 zinc finger protein 576 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF577 64.4242915060327 59.5377540094108 69.3108290026547 1.16414920508589 0.219275975464827 0.554192291850751 1 0.420141 0.41248 0.662327 0.44063 GeneID:84765,Genbank:NM_032679.2,HGNC:HGNC:28673 zinc finger protein 577 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF578 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00593462 0 GeneID:147660,Genbank:XM_017026302.2,HGNC:HGNC:26449 zinc finger protein 578 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF579 490.473708309836 483.750172654871 497.197243964801 1.02779755351017 0.0395561231800685 0.87857587135552 1 9.18118 10.6307 9.89012 11.1876 GeneID:163033,Genbank:XM_017026410.2,HGNC:HGNC:26646 zinc finger protein 579 GO:0003677,GO:0003723,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|RNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF580 902.738639637972 862.894622629615 942.582656646328 1.09234967043122 0.127434749157238 0.421817735743767 1 23.76 24.1028 27.1809 26.995 GeneID:51157,Genbank:NM_207115.1,HGNC:HGNC:29473,MIM:617888 zinc finger protein 580 GO:0001938,GO:0002690,GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0006935,GO:0006954,GO:0010595,GO:0010628,GO:0032757,GO:0046872,GO:0070301 positive regulation of endothelial cell proliferation|positive regulation of leukocyte chemotaxis|DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|chemotaxis|inflammatory response|positive regulation of endothelial cell migration|positive regulation of gene expression|positive regulation of interleukin-8 production|metal ion binding|cellular response to hydrogen peroxide ZNF581 351.212427484119 394.702273323541 307.722581644698 0.779632149198328 -0.359134511561082 0.0580100759156864 0.875517516166731 9.76111 10.6481 7.5112 8.15341 GeneID:51545,Genbank:XM_017026867.1,HGNC:HGNC:25017 zinc finger protein 581 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF582 55.183726959409 50.2842323020138 60.0832216168043 1.1948720079077 0.256856088125414 0.517845576781998 1 0.498167 0.489041 0.504418 0.652297 GeneID:147948,Genbank:NM_144690.2,HGNC:HGNC:26421,MIM:615600 zinc finger protein 582 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF583 78.2652625645017 66.8790163836633 89.6515087453401 1.34050280032587 0.422774233130262 0.199044139759701 1 0.336769 0.33444 0.502756 0.50047 GeneID:147949,Genbank:NM_001159860.1,HGNC:HGNC:26427 zinc finger protein 583 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF584 361.118705670064 386.380868145374 335.856543194754 0.869236990969205 -0.202178524196646 0.279217941883575 1 3.39419 3.65195 3.27552 2.96777 GeneID:201514,Genbank:XM_005258628.5,HGNC:HGNC:27318 zinc finger protein 584 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF585A 117.522167240862 113.896445006246 121.147889475477 1.06366699565411 0.0890465541152555 0.779957017763227 1 0.24193 0.230557 0.322557 0.314993 GeneID:199704,Genbank:NM_001288800.1,HGNC:HGNC:26305 zinc finger protein 585A GO:0003676,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 nucleic acid binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF585B 115.72765185052 98.656205270883 132.799098430157 1.34607953007646 0.428763650852635 0.125174446696436 1 0.519021 0.532426 0.752738 0.585556 GeneID:92285,Genbank:NM_152279.3,HGNC:HGNC:30948 zinc finger protein 585B GO:0003676,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 nucleic acid binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF586 118.708905381388 127.396913196989 110.020897565788 0.863607247654947 -0.211552743940127 0.456710977370308 1 1.97832 1.81798 1.76397 1.42604 GeneID:54807,Genbank:NM_001204814.1,HGNC:HGNC:25949 zinc finger protein 586 GO:0003677,GO:0005634,GO:0006351,GO:0045892,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|negative regulation of transcription, DNA-templated|metal ion binding ZNF587 620.426656608469 587.027725951471 653.825587265467 1.11378995975995 0.155477192657052 0.358198032226869 1 3.20669 3.50209 4.33894 3.3404 GeneID:84914,Genbank:NM_032828.3,HGNC:HGNC:30955 zinc finger protein 587 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF587B 123.864120364792 117.355353784417 130.372886945167 1.11092406729619 0.151760210535293 0.574934963543145 1 1.14229 1.03498 1.44019 1.1937 GeneID:100293516,Genbank:NM_001204818.1,HGNC:HGNC:37142 zinc finger protein 587B GO:0003676,GO:0005634,GO:0045892,GO:0046872 nucleic acid binding|nucleus|negative regulation of transcription, DNA-templated|metal ion binding ZNF589 232.064701413701 199.042373431279 265.087029396124 1.33181203995062 0.413390487690394 0.0589672963921969 0.879410748501007 0.718006 0.780568 1.0292 1.03556 GeneID:51385,Genbank:XM_017006576.2,HGNC:HGNC:16747,MIM:616702 zinc finger protein 589 GO:0000122,GO:0000977,GO:0001227,GO:0005634,GO:0005654,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|nucleoplasm|metal ion binding ZNF592 2083.95631847997 1928.86582576404 2239.04681119589 1.16081003732283 0.215131899304736 0.123901561498958 1 8.35938 8.20668 10.3095 9.28762 GeneID:9640,Genbank:XM_011522248.2,HGNC:HGNC:28986,MIM:613624 zinc finger protein 592 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF593 568.936420317811 651.342749467472 486.53009116815 0.746964776326949 -0.420887881613907 0.129604316355884 1 47.6695 60.1204 37.7574 43.2787 GeneID:51042,Genbank:NM_015871.4,HGNC:HGNC:30943,MIM:616698 zinc finger protein 593 GO:0000055,GO:0003677,GO:0005634,GO:0005730,GO:0006351,GO:0008270,GO:0030687,GO:0043023,GO:0045944,GO:1903026 ribosomal large subunit export from nucleus|DNA binding|nucleus|nucleolus|transcription, DNA-templated|zinc ion binding|preribosome, large subunit precursor|ribosomal large subunit binding|positive regulation of transcription from RNA polymerase II promoter|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding ZNF594 63.9787520642256 51.8504990572557 76.1070050711955 1.46781624969809 0.553671374010968 0.277279173359675 1 0.264873 0.29699 0.559094 0.265315 GeneID:84622,Genbank:NM_032530.1,HGNC:HGNC:29392 zinc finger protein 594 GO:0003677,GO:0005634,GO:0005654,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF595 108.420798171466 106.343460223038 110.498136119894 1.03906846634614 0.0552907195007385 0.857692608426935 1 0.710978 0.663105 0.703864 0.594712 GeneID:152687,Genbank:XM_011513398.2,HGNC:HGNC:27196 zinc finger protein 595 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF596 16.965260815173 15.0285173264075 18.9020043039385 1.25774245678412 0.330836537194254 0.646355121525478 1 0.0860829 0.0822375 0.137968 0.102964 GeneID:169270,Genbank:NM_001287255.1,HGNC:HGNC:27268 zinc finger protein 596 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF597 58.3269183876102 57.5294421268964 59.1243946483241 1.0277241089512 0.0394530271115669 0.937126550764224 1 0.421375 0.415172 0.445509 0.408188 GeneID:146434,Genbank:NM_152457.2,HGNC:HGNC:26573,MIM:614685 zinc finger protein 597 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF598 1638.22401927411 1611.7017121551 1664.74632639311 1.03291217837517 0.0467175966921374 0.771550865923051 1 19.1105 19.769 21.2202 19.761 GeneID:90850,Genbank:NM_178167.3,HGNC:HGNC:28079,MIM:617508 zinc finger protein 598 GO:0003723,GO:0006513,GO:0016567,GO:0043022,GO:0046872,GO:0061630,GO:0072344 RNA binding|protein monoubiquitination|protein ubiquitination|ribosome binding|metal ion binding|ubiquitin protein ligase activity|rescue of stalled ribosome ZNF599 88.6025926407137 88.5185933089412 88.6865919724862 1.00189789124821 0.00273548328736593 1 1 0.615399 0.545247 0.722747 0.605382 GeneID:148103,Genbank:NM_001007248.2,HGNC:HGNC:26408 zinc finger protein 599 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF600 46.1618160854748 48.2180854897065 44.1055466812432 0.914709620535613 -0.128614270071928 0.811865930717065 1 0.383725 0.24607 0.288961 0.223559 GeneID:162966,Genbank:NM_198457.3,HGNC:HGNC:30951 zinc finger protein 600 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF605 78.7209117398621 67.772915293316 89.6689081864081 1.32307881103134 0.403899000314739 0.235299797054047 1 0.213772 0.261406 0.39302 0.241747 GeneID:100289635,Genbank:NM_001164715.1,HGNC:HGNC:28068 zinc finger protein 605 GO:0000976,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF606 29.948592941357 28.3947153482032 31.5024705345107 1.10944836559188 0.14984252518434 0.7873734172537 1 0.228713 0.193147 0.279007 0.22784 GeneID:80095,Genbank:NM_025027.4,HGNC:HGNC:25879,MIM:613905 zinc finger protein 606 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF607 88.2748091514174 99.0021978487856 77.5474204540492 0.783289887892125 -0.352381761285083 0.264514386049214 1 0.715444 0.778145 0.679804 0.518037 GeneID:84775,Genbank:NM_032689.4,HGNC:HGNC:28192 zinc finger protein 607 GO:0000122,GO:0000981,GO:0001649,GO:0001850,GO:0001851,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005743,GO:0005769,GO:0005886,GO:0005887,GO:0006355,GO:0006851,GO:0007005,GO:0007165,GO:0008022,GO:0008285,GO:0009986,GO:0010628,GO:0010942,GO:0010944,GO:0016020,GO:0016575,GO:0019899,GO:0030308,GO:0031871,GO:0042177,GO:0042826,GO:0042981,GO:0043209,GO:0044212,GO:0045745,GO:0045892,GO:0045893,GO:0045917,GO:0050821,GO:0050847,GO:0060766,GO:0070062,GO:0070373,GO:0070374,GO:0071354,GO:0071897,GO:2000323 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II transcription factor activity, sequence-specific DNA binding|osteoblast differentiation|complement component C3a binding|complement component C3b binding|nucleus|nucleoplasm|cytoplasm|mitochondrion|mitochondrial inner membrane|early endosome|plasma membrane|integral component of plasma membrane|regulation of transcription, DNA-templated|mitochondrial calcium ion transmembrane transport|mitochondrion organization|signal transduction|protein C-terminus binding|negative regulation of cell proliferation|cell surface|positive regulation of gene expression|positive regulation of cell death|negative regulation of transcription by competitive promoter binding|membrane|histone deacetylation|enzyme binding|negative regulation of cell growth|proteinase activated receptor binding|negative regulation of protein catabolic process|histone deacetylase binding|regulation of apoptotic process|myelin sheath|transcription regulatory region DNA binding|positive regulation of G-protein coupled receptor protein signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription, DNA-templated|positive regulation of complement activation|protein stabilization|progesterone receptor signaling pathway|negative regulation of androgen receptor signaling pathway|extracellular exosome|negative regulation of ERK1 and ERK2 cascade|positive regulation of ERK1 and ERK2 cascade|cellular response to interleukin-6|DNA biosynthetic process|negative regulation of glucocorticoid receptor signaling pathway ZNF608 361.239233676882 344.436641330888 378.041826022876 1.09756564970016 0.134307235582258 0.47192162941537 1 1.4043 1.32097 1.6772 1.30786 GeneID:57507,Genbank:XM_005272037.3,HGNC:HGNC:29238 zinc finger protein 608 GO:0000122,GO:0003676,GO:0006351,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|nucleic acid binding|transcription, DNA-templated|metal ion binding ZNF609 2886.75515365716 2812.41988251502 2961.09042479931 1.05286214309911 0.0743165489113274 0.589087844059602 1 10.2022 10.1939 11.1995 10.6422 GeneID:23060,Genbank:XM_017022021.1,HGNC:HGNC:29003,MIM:617474 zinc finger protein 609 GO:0003676,GO:0005634,GO:0005654,GO:0006351,GO:0006357,GO:0007517,GO:0032039,GO:0045944,GO:0046872,GO:2000291,GO:2001224 nucleic acid binding|nucleus|nucleoplasm|transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter|muscle organ development|integrator complex|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|regulation of myoblast proliferation|positive regulation of neuron migration ZNF610 48.4746695201802 40.7327442913992 56.2165947489613 1.38013275871598 0.464807050430235 0.255239947173041 1 0.572689 0.500032 0.738781 0.726372 GeneID:162963,Genbank:NM_001161425.1,HGNC:HGNC:26687 zinc finger protein 610 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF611 101.207079695388 110.811937770447 91.6022216203296 0.826645788020497 -0.274658817890873 0.346565396272531 1 0.61956 0.782071 0.705502 0.499034 GeneID:81856,Genbank:NM_001161500.1,HGNC:HGNC:28766 zinc finger protein 611 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF613 70.5874329062071 70.895640148692 70.2792256637222 0.991305325917405 -0.0125986133148808 0.999125503787783 1 0.608471 0.666487 0.74435 0.436551 GeneID:79898,Genbank:XM_011527333.2,HGNC:HGNC:25827 zinc finger protein 613 GO:0000122,GO:0003700,GO:0005634,GO:0006351,GO:0044212,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF614 101.768059073946 108.534068549184 95.0020495987068 0.875320080308744 -0.192117427846331 0.600321093943528 1 0.927403 0.723656 0.85691 0.559223 GeneID:80110,Genbank:NM_025040.3,HGNC:HGNC:24722 zinc finger protein 614 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF615 29.8023391871686 28.1065577000935 31.4981206742438 1.12066803093923 0.164358980153996 0.788136254451913 1 0.150037 0.220497 0.198149 0.240151 GeneID:284370,Genbank:XM_017026648.2,HGNC:HGNC:24740 zinc finger protein 615 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF616 60.4947620780526 34.2275458970066 86.7619782590987 2.53485828403159 1.3419050929328 0.000405802216904137 0.0555498145806552 0.201355 0.258307 0.742602 0.460522 GeneID:90317,Genbank:NM_178523.4,HGNC:HGNC:28062 zinc finger protein 616 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF618 570.189526012721 481.250772369545 659.128279655896 1.36961500635216 0.453770414000676 0.00737762234896679 0.340518730665856 0.700568 0.683719 1.03929 0.876198 GeneID:114991,Genbank:NM_001318042.1,HGNC:HGNC:29416,MIM:617077 zinc finger protein 618 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF619 94.451028090112 94.879712879279 94.022343300945 0.990963615378718 -0.0130960070783567 1 1 0.873352 0.618858 0.797391 0.699722 GeneID:285267,Genbank:NM_001145082.2,HGNC:HGNC:26910 zinc finger protein 619 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF620 164.572748540574 162.41249679917 166.733000281977 1.02660203843888 0.0378770303043592 0.89614104774867 1 0.865158 0.891817 1.06312 0.686161 GeneID:253639,Genbank:XM_017006069.2,HGNC:HGNC:28742 zinc finger protein 620 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF621 887.742678121831 899.695970049393 875.789386194269 0.973428152786089 -0.038853595083418 0.8221982528163 1 4.06261 3.83264 4.30495 3.49818 GeneID:285268,Genbank:XM_011533610.3,HGNC:HGNC:24787 zinc finger protein 621 GO:0003677,GO:0003700,GO:0006351,GO:0006355,GO:0016607,GO:0046872 DNA binding|DNA binding transcription factor activity|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck|metal ion binding ZNF622 929.569672959907 879.739346739798 979.399999180016 1.11328429586507 0.154822056166481 0.324843123971062 1 16.789 17.6712 19.1653 19.314 GeneID:90441,Genbank:NM_033414.2,HGNC:HGNC:30958,MIM:608694 zinc finger protein 622 GO:0003723,GO:0005634,GO:0005730,GO:0005794,GO:0005829,GO:0008270,GO:0008631,GO:0022625,GO:0030687,GO:0033674,GO:0042273,GO:0043065,GO:0043410,GO:0046330 RNA binding|nucleus|nucleolus|Golgi apparatus|cytosol|zinc ion binding|intrinsic apoptotic signaling pathway in response to oxidative stress|cytosolic large ribosomal subunit|preribosome, large subunit precursor|positive regulation of kinase activity|ribosomal large subunit biogenesis|positive regulation of apoptotic process|positive regulation of MAPK cascade|positive regulation of JNK cascade ZNF623 357.500057392263 343.754464830191 371.245649954336 1.07997331798359 0.110995669344051 0.555050795731012 1 2.72933 2.67274 3.20139 2.67418 GeneID:9831,Genbank:NM_001261843.1,HGNC:HGNC:29084 zinc finger protein 623 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF624 10.3109967150861 11.8959838159236 8.72600961424868 0.733525679697742 -0.447080621389409 0.665734658770868 1 0.081886 0.0531587 0.0792608 0.036849 GeneID:57547,Genbank:NM_020787.3,HGNC:HGNC:29254 zinc finger protein 624 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF625 34.2218532565617 29.1827530533781 39.2609534597453 1.34534782883346 0.427979218178132 0.391663404271976 1 0.483554 0.439629 0.647073 0.584735 GeneID:90589,Genbank:NM_145233.3,HGNC:HGNC:30571 zinc finger protein 625 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF626 0.726297495800659 0 1.45259499160132 Inf Inf 0.598878990696116 1 0 0 0 0.0159235 GeneID:199777,Genbank:NM_001076675.2,HGNC:HGNC:30461 zinc finger protein 626 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF627 163.249717842892 143.819209490114 182.680226195669 1.27020741417874 0.345064096189915 0.277067615314202 1 1.22194 1.71541 1.6242 2.03617 GeneID:199692,Genbank:XM_011527780.2,HGNC:HGNC:30570,MIM:612248 zinc finger protein 627 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF628 285.782841083407 288.060846797285 283.504835369529 0.984183857409255 -0.0230002413197421 0.904069576343898 1 2.29047 2.35587 2.42632 2.2669 GeneID:89887,Genbank:NM_033113.2,HGNC:HGNC:28054,MIM:610671 zinc finger protein 628 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF629 738.772961069845 596.992850124889 880.553072014801 1.47498093458002 0.560696306498466 0.000559339286632193 0.0663583556644534 3.11054 3.58478 5.01521 4.92484 GeneID:23361,Genbank:NM_001080417.2,HGNC:HGNC:29008 zinc finger protein 629 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF638 249.958391717628 265.33424886276 234.582534572496 0.884101979212757 -0.177715303982278 0.588344010266681 1 0.932329 0.677948 0.825379 0.660028 GeneID:27332,Genbank:XM_017003809.2,HGNC:HGNC:17894,MIM:614349 zinc finger protein 638 GO:0003690,GO:0003723,GO:0005654,GO:0005737,GO:0006351,GO:0006355,GO:0008270,GO:0008380,GO:0016607,GO:0043231 double-stranded DNA binding|RNA binding|nucleoplasm|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding|RNA splicing|nuclear speck|intracellular membrane-bounded organelle ZNF639 622.339240199247 681.992665724158 562.685814674336 0.825061386953277 -0.277426630852149 0.102654752499016 1 7.76455 6.99179 6.79929 5.72508 GeneID:51193,Genbank:XM_017006551.1,HGNC:HGNC:30950 zinc finger protein 639 GO:0000978,GO:0001077,GO:0003700,GO:0005634,GO:0005654,GO:0030307,GO:0043621,GO:0043922,GO:0043923,GO:0044212,GO:0045892,GO:0045944,GO:0046718,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|nucleoplasm|positive regulation of cell growth|protein self-association|negative regulation by host of viral transcription|positive regulation by host of viral transcription|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|viral entry into host cell|metal ion binding ZNF641 306.811305623303 280.699967112817 332.922644133789 1.18604447146224 0.246158105630277 0.215169941314791 1 0.908958 0.955207 1.07001 1.13768 GeneID:121274,Genbank:XM_017018799.2,HGNC:HGNC:31834,MIM:613906 zinc finger protein 641 GO:0000981,GO:0003677,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|metal ion binding ZNF644 249.567495489651 246.106811327692 253.02817965161 1.02812343261277 0.0400134794426428 0.901754588080856 1 1.33339 1.09363 1.56051 0.934745 GeneID:84146,Genbank:NM_032186.4,HGNC:HGNC:29222,MIM:614159 zinc finger protein 644 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF646 708.067379522282 704.210591947364 711.924167097199 1.01095350629207 0.0157166492841895 0.944189082962503 1 3.13811 3.28836 3.55077 3.33602 GeneID:9726,Genbank:XM_005255710.4,HGNC:HGNC:29004 zinc finger protein 646 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF648 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00379563 0 GeneID:127665,Genbank:XM_024453258.1,HGNC:HGNC:18190 zinc finger protein 648 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF649 152.701337160942 146.94193434549 158.460739976393 1.07839018645161 0.108879272902791 0.682789730553062 1 1.42489 1.48446 1.46847 1.67458 GeneID:65251,Genbank:NM_023074.3,HGNC:HGNC:25741,MIM:611903 zinc finger protein 649 GO:0000122,GO:0003700,GO:0005615,GO:0005634,GO:0006351,GO:0044212,GO:0045944,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|DNA binding transcription factor activity|extracellular space|nucleus|transcription, DNA-templated|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF652 231.547932749972 207.15205620049 255.943809299453 1.23553593429814 0.305136970585617 0.453892681905828 1 0.731758 0.681811 1.11547 0.619133 GeneID:22834,Genbank:NM_014897.2,HGNC:HGNC:29147,MIM:613907 zinc finger protein 652 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF653 258.405877024813 263.836642693274 252.975111356352 0.958832362229729 -0.0606494916570753 0.752220732879424 1 4.135 4.93093 4.50285 4.49134 GeneID:115950,Genbank:NM_138783.3,HGNC:HGNC:25196,MIM:611371 zinc finger protein 653 GO:0003677,GO:0003714,GO:0005576,GO:0005634,GO:0006351,GO:0006355,GO:0008134,GO:0046872,GO:0048019,GO:0050682,GO:1900116,GO:1903507 DNA binding|transcription corepressor activity|extracellular region|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription factor binding|metal ion binding|receptor antagonist activity|AF-2 domain binding|extracellular negative regulation of signal transduction|negative regulation of nucleic acid-templated transcription ZNF654 113.064032377687 108.332154795337 117.795909960037 1.08735869034064 0.120827925107437 0.807663795591542 1 0.696193 0.460823 0.840777 0.384283 GeneID:55279,Genbank:XM_017006789.2,HGNC:HGNC:25612 zinc finger protein 654 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF655 710.074686968624 746.528203303367 673.621170633881 0.902338542138295 -0.14825928509802 0.362212836424464 1 6.09161 5.69696 5.95484 4.91004 GeneID:79027,Genbank:NM_001083956.1,HGNC:HGNC:30899,MIM:617891 zinc finger protein 655 GO:0003677,GO:0003700,GO:0005634,GO:0005730,GO:0005737,GO:0006351,GO:0006355,GO:0046872,GO:2000134 DNA binding|DNA binding transcription factor activity|nucleus|nucleolus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding|negative regulation of G1/S transition of mitotic cell cycle ZNF658 12.8048977518358 12.0400626399784 13.5697328636932 1.1270483609143 0.172549421946978 0.847920215134252 1 0.0643647 0.0237927 0.0618618 0.0399269 GeneID:26149,Genbank:NM_001317916.1,HGNC:HGNC:25226,MIM:616290 zinc finger protein 658 GO:0000976,GO:0003700,GO:0005634,GO:0006351,GO:0042254,GO:0045892,GO:0046872,GO:0071294 transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|ribosome biogenesis|negative regulation of transcription, DNA-templated|metal ion binding|cellular response to zinc ion ZNF66 6.37805973311572 4.99676656894351 7.75935289728793 1.55287480218003 0.634941519644735 0.758271497754474 1 0.0131329 0.0251387 0.082061 0.00586576 GeneID:7617,Genbank:NM_001355197.1,HGNC:HGNC:13135 zinc finger protein 66 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF660 7.40079072631849 6.07296192222811 8.72861953040887 1.43729199066119 0.523353179879081 0.74384624745387 1 0.0274948 0.0530976 0.101397 0.0185335 GeneID:285349,Genbank:NM_173658.3,HGNC:HGNC:26720 zinc finger protein 660 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF664 2164.94036825449 1732.12871351764 2597.75202299134 1.49974537268409 0.584717580222128 2.71389428006821e-05 0.00965905128657166 16.2895 15.5056 26.0825 22.0795 GeneID:144348,Genbank:NM_152437.2,HGNC:HGNC:25406,MIM:617890 zinc finger protein 664 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF664-RFLNA 0.511582989614737 0.538097676642304 0.48506830258717 0.901450282435646 -0.149680169798226 1 1 3.95725e-05 0.0385977 0.0948405 2.94942e-05 GeneID:100533183,Genbank:NM_001204299.2 ZNF664-RFLNA readthrough GO:0005737,GO:0005856,GO:0031005,GO:0061181,GO:0061572 cytoplasm|cytoskeleton|filamin binding|regulation of chondrocyte development|actin filament bundle organization ZNF665 18.0886124710892 17.2769605823466 18.9002643598317 1.09395771725866 0.129556977362536 0.851913575740753 1 0.0856948 0.0452726 0.0914502 0.0933609 GeneID:79788,Genbank:NM_001353459.1,HGNC:HGNC:25885 zinc finger protein 665 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF667 123.143079628487 127.540992021044 118.74516723593 0.931035311504691 -0.103092208771804 0.728267721757286 1 0.544841 0.536915 0.575666 0.418171 GeneID:63934,Genbank:XM_024451637.1,HGNC:HGNC:28854,MIM:611024 zinc finger protein 667 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF668 337.848286091374 349.550094760272 326.146477422476 0.933046456892405 -0.0999791794483766 0.681189329931126 1 3.57164 4.56123 4.0403 3.99976 GeneID:79759,Genbank:NM_024706.4,HGNC:HGNC:25821,MIM:617103 zinc finger protein 668 GO:0000978,GO:0001078,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF669 118.282775556532 110.552189086807 126.013362026257 1.1398540641046 0.188849127486662 0.496805983383701 1 1.66752 1.69039 2.25001 1.89265 GeneID:79862,Genbank:NM_001142572.1,HGNC:HGNC:25736 zinc finger protein 669 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF670 49.0389192320467 60.7580281867502 37.3198102773432 0.614236692517973 -0.703133398052948 0.0887072326713346 0.974530681214803 0.660387 0.562955 0.435896 0.32643 GeneID:93474,Genbank:NM_001204220.1,HGNC:HGNC:28167 zinc finger protein 670 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF671 92.2842684183406 83.7717667685303 100.796770068151 1.20323080145441 0.266913404090253 0.387294392252585 1 0.964684 0.862799 1.17007 1.19283 GeneID:79891,Genbank:XM_017027314.1,HGNC:HGNC:26279 zinc finger protein 671 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF672 851.662046747548 855.735656698995 847.588436796102 0.990479279624363 -0.0138012999804249 0.92606599014576 1 16.8287 16.6563 16.5332 16.9528 GeneID:79894,Genbank:NM_024836.2,HGNC:HGNC:26179 zinc finger protein 672 GO:0003677,GO:0003700,GO:0005654,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF674 26.4648791161627 23.3597311596827 29.5700270726426 1.26585476821234 0.340111893550761 0.576748321736493 1 0.130598 0.181122 0.22851 0.124722 GeneID:641339,Genbank:NM_001146291.1,HGNC:HGNC:17625,MIM:300573 zinc finger protein 674 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF675 78.5415977988016 67.9071854622629 89.1760101353403 1.31320433218215 0.393091414395595 0.232085931434069 1 0.864049 0.905007 1.34308 0.910475 GeneID:171392,Genbank:NM_138330.2,HGNC:HGNC:30768 zinc finger protein 675 GO:0000122,GO:0003677,GO:0005634,GO:0006351,GO:0007249,GO:0008270,GO:0010804,GO:0019221,GO:0031625,GO:0032088,GO:0043508,GO:0045453,GO:0045671,GO:0046329,GO:0048471,GO:2000660,GO:2000678 negative regulation of transcription from RNA polymerase II promoter|DNA binding|nucleus|transcription, DNA-templated|I-kappaB kinase/NF-kappaB signaling|zinc ion binding|negative regulation of tumor necrosis factor-mediated signaling pathway|cytokine-mediated signaling pathway|ubiquitin protein ligase binding|negative regulation of NF-kappaB transcription factor activity|negative regulation of JUN kinase activity|bone resorption|negative regulation of osteoclast differentiation|negative regulation of JNK cascade|perinuclear region of cytoplasm|negative regulation of interleukin-1-mediated signaling pathway|negative regulation of transcription regulatory region DNA binding ZNF676 1.27070322989325 2.05633815719933 0.48506830258717 0.235889365223771 -2.08381771694066 0.63179572723844 1 0.0218436 0 0.0105827 0 GeneID:163223,Genbank:NM_001001411.2,HGNC:HGNC:20429 zinc finger protein 676 GO:0003676,GO:0003700,GO:0005622,GO:0006355,GO:0046872 nucleic acid binding|DNA binding transcription factor activity|intracellular|regulation of transcription, DNA-templated|metal ion binding ZNF677 22.3170142065921 24.2820390338045 20.3519893793796 0.838149932592002 -0.254719751131307 0.7130967684801 1 0.0761399 0.111087 0.092531 0.120113 GeneID:342926,Genbank:NM_182609.3,HGNC:HGNC:28730 zinc finger protein 677 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF678 31.7559660970162 25.2141555630343 38.2977766309981 1.51889983129736 0.603026729842871 0.339251710375657 1 0.104288 0.118739 0.259443 0.113465 GeneID:339500,Genbank:NM_178549.3,HGNC:HGNC:28652 zinc finger protein 678 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF679 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.0200404 0 GeneID:168417,Genbank:NM_153363.2,HGNC:HGNC:28650 zinc finger protein 679 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF680 61.5108256735376 59.0378739523455 63.9837773947298 1.08377509404178 0.116065398411813 0.782952143449534 1 0.462905 0.346341 0.570586 0.264865 GeneID:340252,Genbank:NM_178558.4,HGNC:HGNC:26897 zinc finger protein 680 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF681 21.5240784569861 14.9324647770376 28.1156921369345 1.88285675250139 0.912923244074772 0.138032278226974 1 0.0940732 0.0926704 0.241776 0.103118 GeneID:148213,Genbank:NM_138286.2,HGNC:HGNC:26457 zinc finger protein 681 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF682 36.2471944790114 27.9046439462458 44.589745011777 1.59793277053355 0.676206711358401 0.148770997012329 1 0.202287 0.10837 0.284314 0.236322 GeneID:91120,Genbank:NM_033196.2,HGNC:HGNC:28857 zinc finger protein 682 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF684 41.1912357925977 33.929579593789 48.4528919914064 1.42804280428738 0.514039223489998 0.248659760456285 1 0.325827 0.313361 0.312846 0.345283 GeneID:127396,Genbank:XM_017000290.1,HGNC:HGNC:28418 zinc finger protein 684 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF687 1105.33296555793 1041.76865034234 1168.89728077351 1.12203153779814 0.166113227448953 0.289508598558006 1 6.33255 7.32224 7.76466 7.80042 GeneID:57592,Genbank:NM_001304764.1,HGNC:HGNC:29277,MIM:610568 zinc finger protein 687 GO:0003677,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF688 88.8574634343932 71.5876253044971 106.127301564289 1.48248110078911 0.568013712884857 0.0724262628293094 0.929470372976137 0.906349 0.802286 1.253 1.38417 GeneID:146542,Genbank:XM_024450165.1,HGNC:HGNC:30489 zinc finger protein 688 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF689 536.457778043475 513.14363111635 559.771924970599 1.09086791889594 0.125476432285429 0.476154721833051 1 6.41972 6.76432 7.78293 6.72148 GeneID:115509,Genbank:NM_138447.2,HGNC:HGNC:25173 zinc finger protein 689 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0035914,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|skeletal muscle cell differentiation|metal ion binding ZNF69 44.9985591158574 38.1383084575575 51.8588097741573 1.35975642002761 0.443348237437819 0.29641127787407 1 0.238705 0.198607 0.347658 0.254888 GeneID:7620,Genbank:XM_017027231.1,HGNC:HGNC:13138,MIM:194543 zinc finger protein 69 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF691 133.862683039642 120.881906147488 146.843459931796 1.21476790540209 0.280680697608044 0.285123846309968 1 2.15439 2.09162 2.74148 2.43169 GeneID:51058,Genbank:XM_006710671.4,HGNC:HGNC:28028 zinc finger protein 691 GO:0003677,GO:0005634,GO:0046872 DNA binding|nucleus|metal ion binding ZNF692 316.282464215996 348.568934955503 283.99599347649 0.814748432796352 -0.295573423006806 0.132097714200999 1 3.31808 3.36789 2.92942 2.41455 GeneID:55657,Genbank:XM_011544223.2,HGNC:HGNC:26049,MIM:617758 zinc finger protein 692 GO:0000122,GO:0000978,GO:0001078,GO:0005634,GO:0005730,GO:0006351,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|nucleolus|transcription, DNA-templated|metal ion binding ZNF695 0.756618690593418 1.02816907859967 0.48506830258717 0.471778730447542 -1.08381771694066 0.981150510531627 1 0.0112008 0.0108422 0.0108245 0 GeneID:57116,Genbank:NM_001204221.1,HGNC:HGNC:30954,MIM:616348 zinc finger protein 695 GO:0003676,GO:0005634,GO:0006355,GO:0046872 nucleic acid binding|nucleus|regulation of transcription, DNA-templated|metal ion binding ZNF696 257.024626515965 262.538916275925 251.510336756004 0.957992591436117 -0.0619135958567024 0.774259528125047 1 2.64954 2.62792 2.41315 2.54976 GeneID:79943,Genbank:NM_030895.2,HGNC:HGNC:25872 zinc finger protein 696 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF697 1216.95143266011 1520.41212722037 913.490738099845 0.600817845204836 -0.735000431159378 9.28387151932409e-07 0.000708049934540451 8.18628 7.44187 4.68093 4.86665 GeneID:90874,Genbank:NM_001080470.1,HGNC:HGNC:32034 zinc finger protein 697 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF699 68.9037962460344 63.6504303238094 74.1571621682594 1.16506929789789 0.220415768407723 0.538577469341954 1 0.381793 0.386659 0.533913 0.366834 GeneID:374879,Genbank:NM_198535.2,HGNC:HGNC:24750,MIM:609571 zinc finger protein 699 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF7 330.215255029779 325.065124971765 335.365385087793 1.03168675851315 0.0450050051239074 0.827151976286784 1 1.9603 1.99873 2.15832 2.05379 GeneID:7553,Genbank:XM_017013816.2,HGNC:HGNC:13139,MIM:194531 zinc finger protein 7 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0007275,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|metal ion binding ZNF70 110.899757141383 111.311817827512 110.487696455254 0.992596281434052 -0.0107210450142691 0.954818468475209 1 0.678585 1.00066 0.828745 0.946675 GeneID:7621,Genbank:NM_021916.3,HGNC:HGNC:13140,MIM:194544 zinc finger protein 70 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF700 74.9066562439744 77.5929436418244 72.2203688461243 0.93075949250617 -0.103519670169164 0.812755147415218 1 0.886606 0.652585 0.862223 0.547235 GeneID:90592,Genbank:NM_001271848.1,HGNC:HGNC:25292 zinc finger protein 700 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF701 116.91252877427 107.803865773802 126.021191774737 1.16898583246689 0.22525744522148 0.415109876012396 1 0.78959 0.648997 0.998692 0.729645 GeneID:55762,Genbank:NM_018260.2,HGNC:HGNC:25597 zinc finger protein 701 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF703 681.95827222995 713.070094802174 650.846449657725 0.912738389117677 -0.131726683534944 0.410338640561795 1 14.4562 14.3378 13.6425 13.4819 GeneID:80139,Genbank:NM_025069.2,HGNC:HGNC:25883,MIM:617045 zinc finger protein 703 GO:0003676,GO:0005634,GO:0005737,GO:0006351,GO:0006355,GO:0008284,GO:0010718,GO:0016363,GO:0017015,GO:0030335,GO:0033601,GO:0034111,GO:0034333,GO:0043234,GO:0045892,GO:0046872,GO:0051726,GO:0060644,GO:0060828,GO:0070491,GO:0071392 nucleic acid binding|nucleus|cytoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|nuclear matrix|regulation of transforming growth factor beta receptor signaling pathway|positive regulation of cell migration|positive regulation of mammary gland epithelial cell proliferation|negative regulation of homotypic cell-cell adhesion|adherens junction assembly|protein complex|negative regulation of transcription, DNA-templated|metal ion binding|regulation of cell cycle|mammary gland epithelial cell differentiation|regulation of canonical Wnt signaling pathway|repressing transcription factor binding|cellular response to estradiol stimulus ZNF704 76.592442021891 75.1523952871455 78.0324887566364 1.03832337556889 0.0542558268110076 0.879093408822994 1 0.20274 0.178946 0.218105 0.178689 GeneID:619279,Genbank:XM_017013725.1,HGNC:HGNC:32291 zinc finger protein 704 GO:0001158,GO:0005634,GO:0006357,GO:0046872 enhancer sequence-specific DNA binding|nucleus|regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF706 1074.33129673201 1130.00686065657 1018.65573280744 0.901459777169465 -0.149664974358695 0.322429739661895 1 5.74633 6.7223 5.66929 5.31113 GeneID:51123,Genbank:NM_001267709.1,HGNC:HGNC:24992 zinc finger protein 706 GO:0005634,GO:0005737,GO:0006417,GO:0045892,GO:0046872,GO:1902455 nucleus|cytoplasm|regulation of translation|negative regulation of transcription, DNA-templated|metal ion binding|negative regulation of stem cell population maintenance ZNF707 207.177327250175 189.490885420664 224.863769079685 1.18667327233441 0.246922771316789 0.279958394673585 1 2.19553 2.20937 2.54147 2.59042 GeneID:286075,Genbank:NM_001288805.1,HGNC:HGNC:27815 zinc finger protein 707 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF708 45.153514110706 40.3867517134966 49.9202765079154 1.23605574575667 0.305743809838658 0.464151833500073 1 0.360173 0.233612 0.387733 0.266169 GeneID:7562,Genbank:XM_017027203.2,HGNC:HGNC:12945 zinc finger protein 708 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF709 24.1279675424074 24.0320990052719 24.223836079543 1.00797837401673 0.0114646864236348 0.991125454041728 1 0.241931 0.108943 0.12448 0.246144 GeneID:163051,Genbank:NM_152601.3,HGNC:HGNC:20629 zinc finger protein 709 GO:0000976,GO:0005634,GO:0006351,GO:0006355,GO:0046872 transcription regulatory region sequence-specific DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF71 318.359417011767 257.253992058872 379.464841964662 1.47505909987131 0.560772758802044 0.00446308191188927 0.264386940078859 1.76085 1.86804 2.77128 2.5417 GeneID:58491,Genbank:XM_017027078.1,HGNC:HGNC:13141,MIM:194545 zinc finger protein 71 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF710 341.704362854565 285.53303754749 397.87568816164 1.39344886875119 0.478660065123831 0.0121734119492498 0.451317976340705 1.73966 1.45323 2.24002 2.2157 GeneID:374655,Genbank:NM_198526.3,HGNC:HGNC:25352 zinc finger protein 710 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF713 98.8283406430004 83.7717667685303 113.88491451747 1.35946654715002 0.443040650917971 0.13752419194709 1 0.663569 0.647044 0.851689 0.882263 GeneID:349075,Genbank:NM_182633.2,HGNC:HGNC:22043,MIM:616181 zinc finger protein 713 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF714 84.4036052007753 72.3560456994562 96.4511647020945 1.33300768124784 0.414685093754891 0.18591758366916 1 0.355648 0.254889 0.497731 0.346898 GeneID:148206,Genbank:NM_182515.3,HGNC:HGNC:27124 zinc finger protein 714 GO:0000122,GO:0001046,GO:0003682,GO:0005634,GO:0006351,GO:0030154,GO:0043433,GO:0046872 negative regulation of transcription from RNA polymerase II promoter|core promoter sequence-specific DNA binding|chromatin binding|nucleus|transcription, DNA-templated|cell differentiation|negative regulation of DNA binding transcription factor activity|metal ion binding ZNF717 1.72751690134606 1.51824048055703 1.93679332213509 1.27568283611072 0.351269686746377 1 1 0.00552626 0.00525085 0 0.00988885 GeneID:100131827,Genbank:NM_001290210.1,HGNC:HGNC:29448 zinc finger protein 717 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF718 68.5861648743317 58.6634724099739 78.5088573386896 1.33829202591393 0.420392957809356 0.243014011699022 1 0.203122 0.279679 0.354612 0.317975 GeneID:255403,Genbank:XM_017007980.2,HGNC:HGNC:26889 zinc finger protein 718 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF720 71.9250511760877 67.7631066382081 76.0869957139673 1.12283806762581 0.16714988154233 0.637965914132943 1 0.941459 0.892794 0.959814 0.971912 GeneID:124411,Genbank:NM_001130913.1,HGNC:HGNC:26987 zinc finger protein 720 GO:0003676,GO:0005622,GO:0006355 nucleic acid binding|intracellular|regulation of transcription, DNA-templated ZNF721 116.73777811489 100.654708498289 132.820847731491 1.31956914597541 0.400066950468751 0.389345854641593 1 0.31823 0.247509 0.630575 0.216014 GeneID:170960,Genbank:NM_133474.3,HGNC:HGNC:29425 zinc finger protein 721 GO:0003677,GO:0005634,GO:0006355,GO:0006366,GO:0009653,GO:0035108,GO:0046872 DNA binding|nucleus|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|anatomical structure morphogenesis|limb morphogenesis|metal ion binding ZNF724 48.8211099903043 46.267608536985 51.3746114436236 1.11037966015806 0.151053046103506 0.726937368942649 1 0.376629 0.374059 0.520266 0.433369 GeneID:440519,Genbank:XM_024451520.1,HGNC:HGNC:32460 zinc finger protein 724 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF726 115.239532362623 106.419895462192 124.059169263054 1.16575165502891 0.221260477887372 0.510651225029041 1 0.792985 0.479212 0.727348 0.774005 GeneID:730087,Genbank:NM_001348688.1,HGNC:HGNC:32462 zinc finger protein 726 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF727 0.48506830258717 0 0.97013660517434 Inf Inf 0.786255250703003 1 0 0 0.00799156 0 GeneID:442319,Genbank:XM_017012225.2,HGNC:HGNC:22785 zinc finger protein 727 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF730 11.2044174284145 11.2618335899114 11.1470012669175 0.989803407937344 -0.0147860854104307 1 1 0.0645273 0.0210172 0.0730621 0.0387234 GeneID:100129543,Genbank:XM_017026115.2,HGNC:HGNC:32470 zinc finger protein 730 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF736 173.974511948471 171.050468589916 176.898555307026 1.0341892469826 0.0485002095418193 0.815930833678604 1 0.945748 0.720785 0.898091 0.744881 GeneID:728927,Genbank:NM_001170905.2,HGNC:HGNC:32467 zinc finger protein 736 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF737 13.9509671816732 12.8761266198383 15.0258077435081 1.16695091521994 0.222743879076049 0.807768851686607 1 0.0571512 0.051196 0.078536 0.0557871 GeneID:100129842,Genbank:XM_005259697.4,HGNC:HGNC:32468,MIM:603984 zinc finger protein 737 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF738 158.169904469878 158.338038104349 158.001770835408 0.997876269827727 -0.00306715304447974 1 1 0.537494 0.509715 0.596939 0.403703 GeneID:148203,Genbank:NM_001355237.1,HGNC:HGNC:32469 zinc finger protein 738 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0021762,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|substantia nigra development|metal ion binding ZNF74 218.276071978059 212.658511481607 223.893632474511 1.05283174849023 0.0742748997887553 0.763416939134717 1 2.16817 2.46914 2.50744 2.4204 GeneID:7625,Genbank:NM_003426.3,HGNC:HGNC:13144,MIM:194548 zinc finger protein 74 GO:0003677,GO:0003700,GO:0003723,GO:0005654,GO:0006351,GO:0006355,GO:0007275,GO:0015629,GO:0046872 DNA binding|DNA binding transcription factor activity|RNA binding|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|multicellular organism development|actin cytoskeleton|metal ion binding ZNF740 751.048839647779 794.074937948339 708.02274134722 0.891632146427574 -0.165479463198177 0.288800564850463 1 5.97415 6.84868 5.67969 5.97215 GeneID:283337,Genbank:XM_017019181.1,HGNC:HGNC:27465 zinc finger protein 740 GO:0003676,GO:0005634,GO:0006351,GO:0006355,GO:0046872 nucleic acid binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF746 691.824438929054 689.680937677167 693.96794018094 1.00621592140593 0.00893992275400092 0.958149705843145 1 6.96849 6.56545 6.8258 6.98128 GeneID:155061,Genbank:XM_005249956.2,HGNC:HGNC:21948,MIM:613914 zinc finger protein 746 GO:0000122,GO:0000978,GO:0001078,GO:0003700,GO:0005634,GO:0005737,GO:0006351,GO:0031625,GO:0044212,GO:0045892,GO:0045944,GO:0046872,GO:1901216 negative regulation of transcription from RNA polymerase II promoter|RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|cytoplasm|transcription, DNA-templated|ubiquitin protein ligase binding|transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding|positive regulation of neuron death ZNF747 11.2785234041003 11.8959838159236 10.661062992277 0.896190105605761 -0.158123296395494 0.91883279556091 1 0.164816 0.144508 0.139369 0.169394 GeneID:65988,Genbank:NM_001305019.1,HGNC:HGNC:28350 zinc finger protein 747 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF749 130.314846311445 140.916998697947 119.712693924944 0.849526281648572 -0.235269514378928 0.380217633028756 1 1.07503 1.21046 1.07606 0.877161 GeneID:388567,Genbank:XM_011526956.2,HGNC:HGNC:32783 zinc finger protein 749 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF75A 206.410815830261 196.658643005538 216.162988654985 1.09917868521496 0.136425933438201 0.527617404943463 1 1.16459 0.979306 1.20453 1.0673 GeneID:7627,Genbank:NM_001302109.1,HGNC:HGNC:13146,MIM:601473 zinc finger protein 75a GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0008270 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|zinc ion binding ZNF75D 241.940339303296 230.895997557653 252.98468104894 1.09566507745883 0.131806863141007 0.531999237531933 1 0.912236 0.815637 1.0138 0.947898 GeneID:7626,Genbank:NM_007131.4,HGNC:HGNC:13145,MIM:314997 zinc finger protein 75D GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0008270 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|zinc ion binding ZNF76 819.868875965809 723.371402898386 916.366349033233 1.26679924774681 0.341187915775027 0.0536160619718805 0.845191780060668 4.68178 5.03356 6.23359 6.79714 GeneID:7629,Genbank:XM_017011256.1,HGNC:HGNC:13149,MIM:194549 zinc finger protein 76 GO:0001228,GO:0005634,GO:0006357,GO:0006359,GO:0043565,GO:0045944,GO:0046872 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding|nucleus|regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|sequence-specific DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF761 15.4023655816695 12.3860552178809 18.4186759454581 1.4870493972018 0.572452572013339 0.442652271152976 1 0.24288 0.292333 0.646375 0.333637 GeneID:388561,Genbank:NM_001008401.3,HGNC:HGNC:23179 zinc finger protein 761 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF763 9.96316542126057 10.2336645113117 9.69266633120943 0.947135439167045 -0.0783573508798898 0.990481666377852 1 0.103168 0.0989046 0.142931 0.0820163 GeneID:284390,Genbank:NM_001012753.1,HGNC:HGNC:27614 zinc finger protein 763 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF764 137.556143678701 132.624002484249 142.488284873152 1.07437780646135 0.10350140827817 0.678797228954983 1 2.38528 1.61256 2.41002 1.91644 GeneID:92595,Genbank:NM_001172679.1,HGNC:HGNC:28200 zinc finger protein 764 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF765 35.1925701414126 38.8783198880476 31.5068203947777 0.810395626290012 -0.303301706960968 0.535765830677395 1 0.259708 0.294848 0.296418 0.18241 GeneID:91661,Genbank:NM_001040185.2,HGNC:HGNC:25092 zinc finger protein 765 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF765-ZNF761 2.50945368736205 2.59443583384164 2.42447154088245 0.934488920195219 -0.0977505361862428 1 1 0.0828145 0.0393264 0.0717417 0.0289197 GeneID:110116772,Genbank:NM_001350496.1 ZNF765-ZNF761 readthrough GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF766 132.121039718434 121.266116344968 142.9759630919 1.17902648655106 0.237596128484473 0.359237454712005 1 0.946514 0.754487 1.13045 0.878635 GeneID:90321,Genbank:XM_017027441.1,HGNC:HGNC:28063 zinc finger protein 766 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF768 1356.84858576364 1248.26693900661 1465.43023252067 1.17397183785616 0.231397800379332 0.120369281202626 1 14.2137 15.313 16.7384 18.2821 GeneID:79724,Genbank:NM_024671.3,HGNC:HGNC:26273 zinc finger protein 768 GO:0003677,GO:0003723,GO:0005665,GO:0006355,GO:0006366,GO:0046872 DNA binding|RNA binding|DNA-directed RNA polymerase II, core complex|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|metal ion binding ZNF77 110.691350692647 112.83005830807 108.552643077225 0.962089754317371 -0.0557566041474055 0.835289661129926 1 1.32684 1.85854 1.50169 1.78804 GeneID:58492,Genbank:NM_021217.2,HGNC:HGNC:13150,MIM:194551 zinc finger protein 77 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF770 570.871120684109 624.548450490668 517.19379087755 0.828108356479346 -0.27210854077688 0.532477143816616 1 6.01528 4.3461 5.26756 3.32114 GeneID:54989,Genbank:NM_014106.3,HGNC:HGNC:26061 zinc finger protein 770 GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZNF771 180.950476911526 185.022407873255 176.878545949798 0.955984456060933 -0.0649409341563584 0.803737434091469 1 9.31789 8.01503 7.74618 8.55485 GeneID:51333,Genbank:NM_016643.3,HGNC:HGNC:29653 zinc finger protein 771 GO:0003677,GO:0005634,GO:0005730,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF772 229.60685382726 228.983738224508 230.229969430013 1.00544244414546 0.00783049793114684 0.968032913732288 1 1.49825 1.34944 1.70844 1.19614 GeneID:400720,Genbank:XM_005258944.4,HGNC:HGNC:33106 zinc finger protein 772 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF773 138.619779033577 140.080934718087 137.158623349067 0.979138407557737 -0.0304152863520796 0.922997421450306 1 1.83077 1.76835 1.94451 1.58392 GeneID:374928,Genbank:NM_001304335.1,HGNC:HGNC:30487 zinc finger protein 773 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF774 96.4563905307198 93.5633861525696 99.34939490887 1.06184052324555 0.0865671055023461 0.78185278210783 1 0.677445 0.609112 0.694335 0.680859 GeneID:342132,Genbank:XM_017022128.2,HGNC:HGNC:33108 zinc finger protein 774 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF775 273.36871014368 276.328559115632 270.408861171729 0.978577321277072 -0.0312422464718431 0.861075941241903 1 7.2517 8.45564 7.31912 7.97343 GeneID:285971,Genbank:NM_173680.3,HGNC:HGNC:28501 zinc finger protein 775 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF776 393.389496932794 357.860674282477 428.918319583112 1.19856231882173 0.261304923353066 0.156843074157623 1 2.40704 2.35255 3.14351 2.61691 GeneID:284309,Genbank:NM_173632.3,HGNC:HGNC:26765 zinc finger protein 776 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF777 617.027203916807 571.076900750942 662.977507082672 1.16092509819761 0.215274893870341 0.204157113669229 1 6.56341 6.88882 8.09887 7.74592 GeneID:27153,Genbank:NM_015694.2,HGNC:HGNC:22213 zinc finger protein 777 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF778 260.196415412582 281.958458909733 238.434371915432 0.84563652687492 -0.241890400282217 0.257468323202577 1 1.37401 1.22618 1.13678 1.07455 GeneID:197320,Genbank:XM_011522940.2,HGNC:HGNC:26479 zinc finger protein 778 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF780A 97.3651954749536 109.427967458837 85.3024234910702 0.779530365700687 -0.359322872358748 0.237990031191606 1 0.404113 0.377843 0.382388 0.266547 GeneID:284323,Genbank:XM_006723150.4,HGNC:HGNC:27603 zinc finger protein 780A GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF780B 91.737428637124 91.3727778264234 92.1020794478245 1.00798160720019 0.0114693139934215 1 1 0.305676 0.389119 0.475242 0.258063 GeneID:163131,Genbank:NM_001005851.2,HGNC:HGNC:33109 zinc finger protein 780B GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF781 6.20952319103285 6.12098819691306 6.29805818515264 1.02892833355387 0.0411424997954511 1 1 0.0238011 0.0820984 0.0347367 0.075223 GeneID:163115,Genbank:NM_152605.3,HGNC:HGNC:26745 zinc finger protein 781 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF782 31.025658266695 30.5471060547724 31.5042104786175 1.03133208174054 0.0445089452566694 0.94393621459577 1 0.141166 0.0916009 0.140627 0.126731 GeneID:158431,Genbank:XM_011518315.2,HGNC:HGNC:33110 zinc finger protein 782 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF783 311.868883271259 334.914579285597 288.82318725692 0.862378663458023 -0.213606610795198 0.275921523466993 1 2.82308 2.87306 2.272 2.38125 GeneID:100289678,Genbank:NM_001195220.1,HGNC:HGNC:27222 zinc finger family member 783 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0042802 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|identical protein binding ZNF784 182.849216542078 183.004287335633 182.694145748523 0.998305276932991 -0.00244704268046544 0.996684037966732 1 4.89372 3.64347 4.20985 4.55756 GeneID:147808,Genbank:NM_203374.1,HGNC:HGNC:33111 zinc finger protein 784 GO:0002244,GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 hematopoietic progenitor cell differentiation|DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF785 0.511148003588039 0.538097676642304 0.484198330533773 0.899833527539349 -0.152269972565186 1 1 0.0075804 0 0 0.00665995 GeneID:146540,Genbank:XM_024450163.1,HGNC:HGNC:26496 zinc finger protein 785 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF786 202.676297391117 208.103790039936 197.248804742299 0.947838598732132 -0.0772866820012917 0.72648927816476 1 2.3109 2.65371 2.55628 2.13785 GeneID:136051,Genbank:NM_152411.3,HGNC:HGNC:21806 zinc finger protein 786 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF787 1292.10297067069 1312.1683263598 1272.03761498157 0.969416491335714 -0.0448114696082603 0.810857057318124 1 10.9075 13.0937 11.2722 13.0548 GeneID:126208,Genbank:NM_001002836.3,HGNC:HGNC:26998 zinc finger protein 787 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF788P 123.901125175033 105.795553891288 142.006696458779 1.34227471037866 0.424679964192631 0.113036177453229 1 0.807111 0.647057 1.1106 0.939418 GeneID:388507,Genbank:XM_024451503.1,HGNC:HGNC:33112 zinc finger family member 788, pseudogene GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF789 222.331386172353 206.210131016153 238.452641328553 1.15635754729177 0.209587550043242 0.327172742467175 1 1.17034 0.97955 1.41635 1.12467 GeneID:285989,Genbank:XM_011516067.2,HGNC:HGNC:27801 zinc finger protein 789 GO:0003677,GO:0003700,GO:0005654,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleoplasm|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF79 101.350904859318 101.894599985845 100.807209732792 0.989328283803026 -0.0154787722573098 0.969471753333457 1 0.923883 0.863732 0.969107 0.823329 GeneID:7633,Genbank:NM_001322260.1,HGNC:HGNC:13153,MIM:194552 zinc finger protein 79 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF790 54.383638992689 49.6402734208936 59.1270045644843 1.19110956668498 0.252306128603016 0.510186513646553 1 0.350598 0.248631 0.381638 0.313983 GeneID:388536,Genbank:XM_005258903.5,HGNC:HGNC:33114 zinc finger protein 790 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF791 261.751777769592 242.397962520989 281.105593018195 1.15968628652914 0.213734586318439 0.297101521049869 1 1.68993 1.53513 2.07036 1.68085 GeneID:163049,Genbank:NM_153358.2,HGNC:HGNC:26895 zinc finger protein 791 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF792 60.1807006666439 60.7580281867502 59.6033731465375 0.980995844093826 -0.0276810702857917 0.97790723386425 1 0.580138 0.54209 0.529919 0.645893 GeneID:126375,Genbank:NM_175872.4,HGNC:HGNC:24751 zinc finger protein 792 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0042802,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|identical protein binding|metal ion binding ZNF793 0.99578132014851 0.538097676642304 1.45346496365472 2.70111733751434 1.43355631240266 0.835241087836065 1 0.00492524 0 0.00475652 0.00442143 GeneID:390927,Genbank:NM_001013659.2,HGNC:HGNC:33115 zinc finger protein 793 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF799 35.4763875239142 37.9942296335027 32.9585454143256 0.867461868084919 -0.205127753834959 0.69079931760233 1 0.379272 0.346392 0.373542 0.265786 GeneID:90576,Genbank:NM_001080821.2,HGNC:HGNC:28071 zinc finger protein 799 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF8 155.387052083928 155.205504593865 155.568599573991 1.00233944653623 0.00337116612053886 0.995281864756344 1 2.14909 1.87716 1.91579 2.01691 GeneID:7554,Genbank:NM_021089.2,HGNC:HGNC:13154,MIM:194532 zinc finger protein 8 GO:0000122,GO:0003677,GO:0005634,GO:0006351,GO:0008270,GO:0030509 negative regulation of transcription from RNA polymerase II promoter|DNA binding|nucleus|transcription, DNA-templated|zinc ion binding|BMP signaling pathway ZNF800 322.790281497568 333.414939114402 312.165623880735 0.936267657081869 -0.0950070732580375 0.785247061071899 1 0.622805 0.597729 0.734878 0.440296 GeneID:168850,Genbank:XM_006715868.4,HGNC:HGNC:27267 zinc finger protein 800 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF804A 29.2392389198702 26.972527417016 31.5059504227243 1.16807557317926 0.22413361798834 0.670810981264403 1 0.246644 0.161465 0.299145 0.185457 GeneID:91752,Genbank:NM_194250.1,HGNC:HGNC:21711,MIM:612282 zinc finger protein 804A GO:0003676,GO:0005634,GO:0005737,GO:0005886,GO:0010628,GO:0010975,GO:0010976,GO:0030424,GO:0030426,GO:0043025,GO:0043197,GO:0043198,GO:0046872,GO:0098793,GO:0098794,GO:1901588,GO:1902952 nucleic acid binding|nucleus|cytoplasm|plasma membrane|positive regulation of gene expression|regulation of neuron projection development|positive regulation of neuron projection development|axon|growth cone|neuronal cell body|dendritic spine|dendritic shaft|metal ion binding|presynapse|postsynapse|dendritic microtubule|positive regulation of dendritic spine maintenance ZNF804B 0.242534151293585 0 0.48506830258717 Inf Inf 1 1 0 0 0.00574791 0 GeneID:219578,Genbank:NM_181646.4,HGNC:HGNC:21958 zinc finger protein 804B GO:0003676,GO:0046872 nucleic acid binding|metal ion binding ZNF805 83.075496298967 86.6641689055896 79.4868236923445 0.917182091470075 -0.124719909178804 0.711979280659427 1 0.404614 0.433823 0.424026 0.344095 GeneID:390980,Genbank:NM_001023563.3,HGNC:HGNC:23272 zinc finger protein 805 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF806 0.242099165266886 0 0.484198330533773 Inf Inf 1 1 0 0 0 0 GeneID:646915,Genbank:NM_001355461.1,HGNC:HGNC:33228 zinc finger protein 806 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF808 37.3585232058984 42.7312475188056 31.9857988929911 0.748534169963431 -0.417859919269545 0.502109393840752 1 0.397982 0.227385 0.247064 0.192285 GeneID:388558,Genbank:XM_024451509.1,HGNC:HGNC:33230 zinc finger protein 808 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF81 55.2783046108656 62.5644263154169 47.9921829063143 0.767084199963139 -0.382543149229429 0.46062854648606 1 0.189547 0.135262 0.186128 0.0755243 GeneID:347344,Genbank:XM_017029486.1,HGNC:HGNC:13156,MIM:314998 zinc finger protein 81 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF813 34.374620415082 26.5883172195365 42.1609236106275 1.58569356843872 0.665114000545521 0.176264521871937 1 0.215844 0.224534 0.338896 0.337885 GeneID:126017,Genbank:NM_001004301.3,HGNC:HGNC:33257 zinc finger protein 813 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF814 122.53712460558 113.242677470018 131.831571741142 1.16415096045434 0.219278150838428 0.419218281866337 1 0.503594 0.453001 0.687252 0.518294 GeneID:730051,Genbank:NM_001144989.1,HGNC:HGNC:33258 zinc finger protein 814 GO:0003676,GO:0005622,GO:0045892,GO:0046872 nucleic acid binding|intracellular|negative regulation of transcription, DNA-templated|metal ion binding ZNF816 42.2853994805583 42.8949436530763 41.6758553080404 0.97157967253913 -0.0415957887688461 0.941448869952786 1 0.437428 0.555935 0.503086 0.466227 GeneID:125893,Genbank:NM_001202457.1,HGNC:HGNC:26995 zinc finger protein 816 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF816-ZNF321P 52.6691473798806 40.3965603686046 64.9417343911566 1.60760554360534 0.684913457452158 0.0865205333023457 0.964561165794104 0.641756 0.73736 1.12328 1.01136 GeneID:100529240,Genbank:NM_001202473.1,HGNC:HGNC:38879 ZNF816-ZNF321P readthrough GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF821 185.319219716287 147.720163395557 222.918276037016 1.50905787614178 0.593648137886819 0.0113998749234515 0.432003248403162 1.43068 1.44733 2.1864 2.24463 GeneID:55565,Genbank:XM_017023411.1,HGNC:HGNC:28043 zinc finger protein 821 GO:0003700,GO:0005634,GO:0006351,GO:0044212,GO:0045944,GO:0046872 DNA binding transcription factor activity|nucleus|transcription, DNA-templated|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZNF823 51.5523607530756 54.6370399898371 48.4676815163141 0.887084686969306 -0.172856254579146 0.696254779200391 1 0.573805 0.499886 0.573158 0.366612 GeneID:55552,Genbank:NM_017507.1,HGNC:HGNC:30936 zinc finger protein 823 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF827 736.708082544192 688.767421457299 784.648743631085 1.13920710995726 0.188030055514626 0.23289049057112 1 1.59079 1.45052 1.84385 1.60068 GeneID:152485,Genbank:NM_001306215.1,HGNC:HGNC:27193 zinc finger protein 827 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF829 34.0693043511179 32.7573316911345 35.3812770111013 1.08010253535629 0.111168275563153 0.85400361934179 1 0.145944 0.200214 0.205634 0.141988 GeneID:374899,Genbank:XM_011526933.2,HGNC:HGNC:34032 zinc finger protein 829 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF83 162.755647763766 153.437324084775 172.073971442756 1.12146097743261 0.165379421009192 0.592212782959158 1 1.02048 1.01672 1.4806 0.797158 GeneID:55769,Genbank:NM_001277948.1,HGNC:HGNC:13158,MIM:194558 zinc finger protein 83 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF830 355.205679966404 346.954641925576 363.456718007232 1.04756263236621 0.0670365033068161 0.736118814963183 1 7.45079 7.96019 7.9756 8.26589 GeneID:91603,Genbank:NM_052857.3,HGNC:HGNC:28291 zinc finger protein 830 GO:0000278,GO:0001541,GO:0001546,GO:0001832,GO:0003676,GO:0005634,GO:0005654,GO:0005694,GO:0006283,GO:0008270,GO:0016607,GO:0033260,GO:0033314,GO:0043066,GO:0044773,GO:0048478,GO:0051276,GO:0051301,GO:0060729 mitotic cell cycle|ovarian follicle development|preantral ovarian follicle growth|blastocyst growth|nucleic acid binding|nucleus|nucleoplasm|chromosome|transcription-coupled nucleotide-excision repair|zinc ion binding|nuclear speck|nuclear DNA replication|mitotic DNA replication checkpoint|negative regulation of apoptotic process|mitotic DNA damage checkpoint|replication fork protection|chromosome organization|cell division|intestinal epithelial structure maintenance ZNF835 8.81459444173808 8.90752912949446 8.72165975398169 0.979133452968756 -0.0304225866264654 1 1 0.240579 0.0684679 0.091826 0.154464 GeneID:90485,Genbank:NM_001005850.2,HGNC:HGNC:34332 zinc finger protein 835 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF836 102.665465829531 94.841495259702 110.48943639936 1.16499045166686 0.220318130511036 0.463571274682569 1 0.405027 0.362502 0.496625 0.460249 GeneID:162962,Genbank:XM_011526559.3,HGNC:HGNC:34333 zinc finger protein 836 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF837 52.8548585555486 43.6731727031434 62.0365444079539 1.42047258232487 0.506370985187652 0.200713122618729 1 0.683687 0.509869 1.01001 0.710335 GeneID:116412,Genbank:NM_138466.1,HGNC:HGNC:25164 zinc finger protein 837 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF839 298.611511218655 295.786319369017 301.436703068293 1.01910292440614 0.027299763998093 0.904051287428024 1 1.39296 1.38901 1.4674 1.40333 GeneID:55778,Genbank:NM_001267827.1,HGNC:HGNC:20345 zinc finger protein 839 GO:0003676,GO:0046872 nucleic acid binding|metal ion binding ZNF84 88.1878694329578 68.3012043148504 108.074534551065 1.58232253201379 0.662043700891568 0.0349859816056506 0.732464681563529 0.2939 0.310134 0.504176 0.454681 GeneID:7637,Genbank:NM_001127372.2,HGNC:HGNC:13159 zinc finger protein 84 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0008270 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding ZNF841 128.342283219539 111.282391862189 145.402174576889 1.30660540399737 0.385823511715378 0.146282353505182 1 0.651528 0.594254 1.01066 0.779711 GeneID:284371,Genbank:XM_024451465.1,HGNC:HGNC:27611 zinc finger protein 841 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF843 3.21717613121712 3.52655236307142 2.90779989936283 0.824544654380321 -0.278330467921331 0.956771608576397 1 0 0.0942431 0.0255469 0.0718508 GeneID:283933,Genbank:NM_001353381.1,HGNC:HGNC:28710 zinc finger protein 843 GO:0003676,GO:0046872 nucleic acid binding|metal ion binding ZNF844 97.170176966559 84.8097445022379 109.53060943088 1.29148613845889 0.369032159070361 0.230954742014307 1 0.391935 0.476701 0.588848 0.522916 GeneID:284391,Genbank:NM_001136501.2,HGNC:HGNC:25932 zinc finger protein 844 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF845 28.5937775370375 23.7439413571622 33.4436137169128 1.40851146883518 0.494171310936322 0.352772071076049 1 0.148421 0.123668 0.230875 0.167675 GeneID:91664,Genbank:NM_001321522.1,HGNC:HGNC:25112 zinc finger protein 845 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF846 51.9313444951629 42.7988911037065 61.0637978866194 1.4267612153468 0.51274390365681 0.209598246922007 1 0.278216 0.513141 0.548991 0.538526 GeneID:162993,Genbank:NM_001353800.1,HGNC:HGNC:27260 zinc finger protein 846 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF85 96.485600999529 90.228938888238 102.74226311082 1.13868415584585 0.187367632924285 0.528594929485163 1 0.533573 0.553724 0.703557 0.653574 GeneID:7639,Genbank:XM_011528263.2,HGNC:HGNC:13160,MIM:603899 zinc finger protein 85 GO:0003677,GO:0003700,GO:0003714,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|transcription corepressor activity|nucleus|transcription, DNA-templated|metal ion binding ZNF850 54.8228070122781 63.6024040491245 46.0432099754317 0.723922478462754 -0.466092880901183 0.23267209170934 1 0.31538 0.283236 0.235246 0.169974 GeneID:342892,Genbank:NM_001267779.1,HGNC:HGNC:27994 zinc finger protein 850 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF852 37.236594782283 36.1780228497281 38.2951667148379 1.05852016496047 0.0820487531540701 0.872880998447337 1 0.584041 0.260835 0.559735 0.367633 GeneID:285346,Genbank:NM_001287349.1,HGNC:HGNC:27713 zinc finger protein 852 GO:0003676,GO:0005634,GO:0006355,GO:0046872 nucleic acid binding|nucleus|regulation of transcription, DNA-templated|metal ion binding ZNF853 212.227813359451 211.726394952377 212.729231766525 1.00473647517766 0.00681715731659589 1 1 2.44579 2.6553 2.34531 2.86039 GeneID:54753,Genbank:NM_001353546.1,HGNC:HGNC:21767 zinc finger protein 853 GO:0003676,GO:0046872 nucleic acid binding|metal ion binding ZNF860 29.4925039483077 19.2372461901761 39.7477617064392 2.06618771280982 1.04697132876146 0.0459384618531043 0.79332376136203 0.141115 0.0926629 0.314787 0.199747 GeneID:344787,Genbank:NM_001137674.2,HGNC:HGNC:34513 zinc finger protein 860 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF862 318.646484913057 308.720280918648 328.572688907466 1.06430548692733 0.0899123061197763 0.663328091312762 1 1.12446 1.13488 1.20017 1.22877 GeneID:643641,Genbank:NM_001099220.2,HGNC:HGNC:34519 zinc finger protein 862 GO:0003676,GO:0005634,GO:0006351,GO:0006355,GO:0046872,GO:0046983 nucleic acid binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding|protein dimerization activity ZNF865 623.367707343981 573.556683726053 673.17873096191 1.17369172056138 0.23105352291034 0.179415834725102 1 5.53938 6.53646 7.91703 6.92701 GeneID:100507290,Genbank:NM_001195605.1,HGNC:HGNC:38705 zinc finger protein 865 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF878 11.0676024994847 8.08127380474251 14.053931194227 1.7390737566619 0.798319120749077 0.388756535661601 1 0.0140673 0.0944728 0.12141 0.151189 GeneID:729747,Genbank:XM_017027196.1,HGNC:HGNC:37246 zinc finger protein 878 GO:0003676,GO:0005634,GO:0006351,GO:0006355,GO:0046872 nucleic acid binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF879 9.81038535654546 7.98522125537262 11.6355494577183 1.45713551141613 0.543135052115581 0.67752553900155 1 0.0345853 0.0882052 0.155367 0.0619643 GeneID:345462,Genbank:NM_001353372.1,HGNC:HGNC:37273 zinc finger protein 879 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF880 94.2666819257558 78.0447974242048 110.488566427307 1.41570700512883 0.501522715995854 0.100245380768305 1 0.352862 0.320931 0.527894 0.518344 GeneID:400713,Genbank:NM_001145434.1,HGNC:HGNC:37249 zinc finger protein 880 GO:0003676,GO:0003700,GO:0005622,GO:0006355,GO:0046872 nucleic acid binding|DNA binding transcription factor activity|intracellular|regulation of transcription, DNA-templated|metal ion binding ZNF883 56.7460773202844 51.4564802046683 62.0356744359005 1.20559498413326 0.269745319741538 0.483769568595158 1 0.675188 0.60389 0.831214 0.700641 GeneID:169834,Genbank:NM_001101338.1,HGNC:HGNC:27271 zinc finger protein 883 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF888 91.5868076247605 98.3484303125575 84.8251849369636 0.862496581464328 -0.213409356270625 0.624977821278545 1 0.908707 0.567707 0.809564 0.492609 GeneID:388559,Genbank:XM_017026798.2,HGNC:HGNC:38695 zinc finger protein 888 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF891 20.7381409311084 17.728814364727 23.7474674974898 1.33948424350009 0.421677610700274 0.537887473685516 1 0.149198 0.202934 0.287837 0.245357 GeneID:101060200,Genbank:NM_001277291.1,HGNC:HGNC:38709 zinc finger protein 891 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNF90 18.2185855847257 18.507043414794 17.9301277546573 0.96882723797603 -0.0456886688099669 0.996222358226161 1 0.107638 0.0858567 0.113684 0.105264 GeneID:7643,Genbank:NM_007138.1,HGNC:HGNC:13165,MIM:603973 zinc finger protein 90 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0008270 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|zinc ion binding ZNF91 50.7992949101224 44.8934468804828 56.7051429397621 1.26310512736357 0.336974718630102 0.398970341040532 1 0.190048 0.113519 0.235558 0.194461 GeneID:7644,Genbank:XM_024451693.1,HGNC:HGNC:13166,MIM:603971 zinc finger protein 91 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0008270,GO:0045892,GO:0070895 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|zinc ion binding|negative regulation of transcription, DNA-templated|negative regulation of transposon integration ZNF92 68.4688465941802 73.9223124546982 63.0153807336622 0.852454132468867 -0.230305884961619 0.60437458291506 1 0.783463 0.667629 0.816187 0.470963 GeneID:168374,Genbank:NM_001287533.1,HGNC:HGNC:13168,MIM:603974 zinc finger protein 92 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0008270 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|zinc ion binding ZNF93 70.8614719377037 67.5710015394683 74.151942335939 1.09739297400567 0.134080244179379 0.72106592997168 1 0.597743 0.617515 0.751276 0.574041 GeneID:81931,Genbank:NM_031218.3,HGNC:HGNC:13169,MIM:603975 zinc finger protein 93 GO:0000976,GO:0003700,GO:0005634,GO:0006351,GO:0008270,GO:0045892,GO:0070895 transcription regulatory region sequence-specific DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|zinc ion binding|negative regulation of transcription, DNA-templated|negative regulation of transposon integration ZNF99 0.245035700978681 0.490071401957362 0 0 -Inf 0.990702733019119 1 0 0 0 0 GeneID:7652,Genbank:NM_001080409.2,HGNC:HGNC:13175,MIM:603981 zinc finger protein 99 GO:0003677,GO:0005634,GO:0006351,GO:0006355,GO:0046872 DNA binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZNFX1 2768.91842250627 2071.60985690173 3466.22698811081 1.67320452572805 0.742613805339735 0.25676254750083 1 8.28292 8.79523 20.3938 8.94076 GeneID:57169,Genbank:XM_011528924.2,HGNC:HGNC:29271 zinc finger NFX1-type containing 1 GO:0003700,GO:0003723,GO:0005634,GO:0008270 DNA binding transcription factor activity|RNA binding|nucleus|zinc ion binding ZNHIT1 1963.16748183046 1897.35143656303 2028.98352709788 1.06937675751483 0.0967702257780188 0.631645821312876 1 41.5648 49.1137 47.3141 53.3438 GeneID:10467,Genbank:NM_006349.2,HGNC:HGNC:21688 zinc finger HIT-type containing 1 GO:0000812,GO:0005634,GO:0005654,GO:0031063,GO:0031491,GO:0042826,GO:0043486,GO:0046872 Swr1 complex|nucleus|nucleoplasm|regulation of histone deacetylation|nucleosome binding|histone deacetylase binding|histone exchange|metal ion binding ZNHIT2 187.212263934297 212.552650277129 161.871877591464 0.761561323184696 -0.392967883398175 0.0904987202875791 0.979717040875575 12.1012 11.6438 9.77133 8.50644 GeneID:741,Genbank:NM_014205.3,HGNC:HGNC:1177,MIM:604575 zinc finger HIT-type containing 2 GO:0022008,GO:0046872 neurogenesis|metal ion binding ZNHIT3 874.101063232105 906.94219687513 841.25992958908 0.927578331328768 -0.108458976552503 0.485718836801144 1 13.0056 13.809 11.7851 13.1909 GeneID:9326,Genbank:NM_001281432.1,HGNC:HGNC:12309,MIM:604500 zinc finger HIT-type containing 3 GO:0003779,GO:0005524,GO:0005739,GO:0005741,GO:0005829,GO:0016459,GO:0016887,GO:0032027,GO:0032465,GO:0034642,GO:0060002,GO:0090140 actin binding|ATP binding|mitochondrion|mitochondrial outer membrane|cytosol|myosin complex|ATPase activity|myosin light chain binding|regulation of cytokinesis|mitochondrion migration along actin filament|plus-end directed microfilament motor activity|regulation of mitochondrial fission ZNHIT6 399.552445265515 458.880992668885 340.223897862145 0.741420767688325 -0.431635568317651 0.0190298810568621 0.565914563763644 2.61188 2.84593 2.1846 1.84455 GeneID:54680,Genbank:NM_001170670.1,HGNC:HGNC:26089 zinc finger HIT-type containing 6 GO:0000492,GO:0001094,GO:0019899,GO:0042254,GO:0042802,GO:0046872,GO:0048254,GO:0051117,GO:0051259,GO:0070062,GO:0070761 box C/D snoRNP assembly|TFIID-class transcription factor binding|enzyme binding|ribosome biogenesis|identical protein binding|metal ion binding|snoRNA localization|ATPase binding|protein oligomerization|extracellular exosome|pre-snoRNP complex ZNRD1 337.113050252468 369.900736922455 304.325363582481 0.822721701271654 -0.281523596311585 0.14899498673844 1 16.6145 15.401 13.8072 15.6406 GeneID:30834,Genbank:NM_170783.3,HGNC:HGNC:13182,MIM:607525 zinc ribbon domain containing 1 GO:0003676,GO:0003899,GO:0005654,GO:0005736,GO:0006139,GO:0006361,GO:0006362,GO:0006363,GO:0006379,GO:0008270,GO:0045815 nucleic acid binding|DNA-directed 5'-3' RNA polymerase activity|nucleoplasm|DNA-directed RNA polymerase I complex|nucleobase-containing compound metabolic process|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|mRNA cleavage|zinc ion binding|positive regulation of gene expression, epigenetic hsa00230,hsa00240,hsa03020 Purine metabolism|Pyrimidine metabolism|RNA polymerase ZNRF1 391.696541823546 382.60437575377 400.788707893323 1.04752776834747 0.0669884880546528 0.73260000236986 1 3.25986 3.52212 3.64423 3.60274 GeneID:84937,Genbank:NM_032268.4,HGNC:HGNC:18452,MIM:612060 zinc and ring finger 1 GO:0000209,GO:0004842,GO:0005764,GO:0005768,GO:0005829,GO:0016020,GO:0030054,GO:0030672,GO:0043161,GO:0046872,GO:0061630,GO:0070936 protein polyubiquitination|ubiquitin-protein transferase activity|lysosome|endosome|cytosol|membrane|cell junction|synaptic vesicle membrane|proteasome-mediated ubiquitin-dependent protein catabolic process|metal ion binding|ubiquitin protein ligase activity|protein K48-linked ubiquitination ZNRF2 451.798547691717 442.708636404292 460.888458979142 1.04106498288018 0.058060123923577 0.743091398710556 1 8.51741 8.11846 9.01742 8.43431 GeneID:223082,Genbank:NM_147128.3,HGNC:HGNC:22316,MIM:612061 zinc and ring finger 2 GO:0000209,GO:0004842,GO:0005737,GO:0005765,GO:0005829,GO:0005886,GO:0010008,GO:0030054,GO:0030659,GO:0042734,GO:0042787,GO:0043161,GO:0043234,GO:0046872,GO:0061630 protein polyubiquitination|ubiquitin-protein transferase activity|cytoplasm|lysosomal membrane|cytosol|plasma membrane|endosome membrane|cell junction|cytoplasmic vesicle membrane|presynaptic membrane|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein complex|metal ion binding|ubiquitin protein ligase activity ZNRF3 515.563252844952 538.723396567503 492.4031091224 0.914018422551843 -0.129704850986584 0.437621740891322 1 2.40578 2.80467 2.59009 2.29936 GeneID:84133,Genbank:XM_011530435.2,HGNC:HGNC:18126,MIM:612062 zinc and ring finger 3 GO:0004842,GO:0005109,GO:0005886,GO:0005887,GO:0006511,GO:0016567,GO:0038018,GO:0046872,GO:0060070,GO:0060071,GO:0061630,GO:0072089,GO:0090090,GO:2000051 ubiquitin-protein transferase activity|frizzled binding|plasma membrane|integral component of plasma membrane|ubiquitin-dependent protein catabolic process|protein ubiquitination|Wnt receptor catabolic process|metal ion binding|canonical Wnt signaling pathway|Wnt signaling pathway, planar cell polarity pathway|ubiquitin protein ligase activity|stem cell proliferation|negative regulation of canonical Wnt signaling pathway|negative regulation of non-canonical Wnt signaling pathway ZP1 4.26892336113256 5.6309167949557 2.90692992730943 0.516244518106452 -0.953873537953587 0.562944509525327 1 0 0.0625895 0 0 GeneID:22917,Genbank:NM_207341.3,HGNC:HGNC:13187,MIM:195000 zona pellucida glycoprotein 1 GO:0005576,GO:0005578,GO:0005886,GO:0007339,GO:0016021 extracellular region|proteinaceous extracellular matrix|plasma membrane|binding of sperm to zona pellucida|integral component of membrane ZP3 4.4745016406315 3.13253351048394 5.81646977077905 1.85679410972382 0.8928138511655 0.571424552631933 1 0.0581091 0.0251817 0.107477 0.100369 GeneID:7784,Genbank:NM_007155.5,HGNC:HGNC:13189,MIM:182889 zona pellucida glycoprotein 3 ZPLD1 0.269048838321152 0.538097676642304 0 0 -Inf 0.990703195066487 1 0.0114419 0 0 0 GeneID:131368,Genbank:XM_017005703.1,HGNC:HGNC:27022,MIM:615915 zona pellucida like domain containing 1 GO:0005578,GO:0016021,GO:0030659 proteinaceous extracellular matrix|integral component of membrane|cytoplasmic vesicle membrane ZPR1 1318.62579879886 1314.72251057236 1322.52908702536 1.00593781302916 0.00854112064291897 0.965740319377166 1 16.94 17.7608 18.0542 17.7286 GeneID:8882,Genbank:NM_001317086.1,HGNC:HGNC:13051,MIM:603901 ZPR1 zinc finger GO:0000226,GO:0001833,GO:0001834,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0006397,GO:0007165,GO:0008270,GO:0008283,GO:0008380,GO:0010628,GO:0015030,GO:0021510,GO:0030424,GO:0030426,GO:0030576,GO:0030971,GO:0031369,GO:0031641,GO:0032797,GO:0033120,GO:0042023,GO:0042307,GO:0043025,GO:0043204,GO:0045927,GO:0048471,GO:0061564,GO:0071364,GO:0071931,GO:0097504,GO:1902742,GO:1990261,GO:2000672 microtubule cytoskeleton organization|inner cell mass cell proliferation|trophectodermal cell proliferation|nucleus|nucleoplasm|nucleolus|cytoplasm|mRNA processing|signal transduction|zinc ion binding|cell proliferation|RNA splicing|positive regulation of gene expression|Cajal body|spinal cord development|axon|growth cone|Cajal body organization|receptor tyrosine kinase binding|translation initiation factor binding|regulation of myelination|SMN complex|positive regulation of RNA splicing|DNA endoreduplication|positive regulation of protein import into nucleus|neuronal cell body|perikaryon|positive regulation of growth|perinuclear region of cytoplasm|axon development|cellular response to epidermal growth factor stimulus|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|Gemini of coiled bodies|apoptotic process involved in development|pre-mRNA catabolic process|negative regulation of motor neuron apoptotic process ZRANB1 1219.92884305995 1279.60985741995 1160.24782869996 0.90671998341693 -0.141271013712844 0.346923036128745 1 7.41124 7.59973 7.30992 6.44736 GeneID:54764,Genbank:XM_006717907.2,HGNC:HGNC:18224,MIM:611749 zinc finger RANBP2-type containing 1 GO:0004843,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007010,GO:0016055,GO:0016477,GO:0016579,GO:0022604,GO:0030177,GO:0035523,GO:0036459,GO:0043231,GO:0046872,GO:0070530,GO:0070536,GO:0071947,GO:1990168 thiol-dependent ubiquitin-specific protease activity|nucleus|nucleoplasm|cytoplasm|cytosol|cytoskeleton organization|Wnt signaling pathway|cell migration|protein deubiquitination|regulation of cell morphogenesis|positive regulation of Wnt signaling pathway|protein K29-linked deubiquitination|thiol-dependent ubiquitinyl hydrolase activity|intracellular membrane-bounded organelle|metal ion binding|K63-linked polyubiquitin modification-dependent protein binding|protein K63-linked deubiquitination|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|protein K33-linked deubiquitination ZRANB2 841.981952412048 876.066681550962 807.897223273134 0.92218690687204 -0.116868912248423 0.481455894670078 1 10.4688 9.31442 9.37706 8.5575 GeneID:9406,Genbank:NM_203350.2,HGNC:HGNC:13058,MIM:604347 zinc finger RANBP2-type containing 2 GO:0003700,GO:0003723,GO:0005634,GO:0005654,GO:0006397,GO:0008380,GO:0046872 DNA binding transcription factor activity|RNA binding|nucleus|nucleoplasm|mRNA processing|RNA splicing|metal ion binding ZRANB3 73.9384874306422 77.112680894975 70.7642939663094 0.917673891570287 -0.123946532315188 0.737768012941624 1 0.215665 0.228798 0.243218 0.147932 GeneID:84083,Genbank:XM_011511966.3,HGNC:HGNC:25249,MIM:615655 zinc finger RANBP2-type containing 3 GO:0004386,GO:0004520,GO:0005524,GO:0005634,GO:0006281,GO:0006974,GO:0009411,GO:0031297,GO:0036292,GO:0036310,GO:0043596,GO:0045910,GO:0046872,GO:0048478,GO:0070530 helicase activity|endodeoxyribonuclease activity|ATP binding|nucleus|DNA repair|cellular response to DNA damage stimulus|response to UV|replication fork processing|DNA rewinding|annealing helicase activity|nuclear replication fork|negative regulation of DNA recombination|metal ion binding|replication fork protection|K63-linked polyubiquitin modification-dependent protein binding ZRSR2 107.031429673221 98.7140402006759 115.348819145766 1.16851482232186 0.22467603446701 0.453688480767695 1 0.485392 0.497364 0.601817 0.500864 GeneID:8233,Genbank:NM_005089.3,HGNC:HGNC:23019,MIM:300028 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 GO:0000245,GO:0000398,GO:0005654,GO:0005689,GO:0008380,GO:0030628,GO:0046872,GO:0089701 spliceosomal complex assembly|mRNA splicing, via spliceosome|nucleoplasm|U12-type spliceosomal complex|RNA splicing|pre-mRNA 3'-splice site binding|metal ion binding|U2AF ZSCAN12 109.965550027515 103.61475422025 116.31634583478 1.12258477771931 0.166824401560404 0.587436883988594 1 0.263434 0.344714 0.371521 0.325223 GeneID:9753,Genbank:XM_011515017.3,HGNC:HGNC:13172,MIM:603978 zinc finger and SCAN domain containing 12 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZSCAN16 221.072176048821 223.612570113193 218.53178198445 0.977278611277661 -0.033158177722081 0.913203355949382 1 2.23433 2.30427 1.90638 2.47142 GeneID:80345,Genbank:XM_017011324.1,HGNC:HGNC:20813 zinc finger and SCAN domain containing 16 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZSCAN18 0.538097676642304 1.07619535328461 0 0 -Inf 0.746054226339504 1 0.0338045 0 0 0 GeneID:65982,Genbank:XM_006723335.2,HGNC:HGNC:21037 zinc finger and SCAN domain containing 18 GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZSCAN2 115.848645145904 108.121449387236 123.575840904573 1.14293548232033 0.192743967013821 0.518886616258001 1 0.574035 0.692915 0.718537 0.773229 GeneID:54993,Genbank:NM_181877.3,HGNC:HGNC:20994 zinc finger and SCAN domain containing 2 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0007275,GO:0007283,GO:0030154,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|multicellular organism development|spermatogenesis|cell differentiation|metal ion binding ZSCAN20 211.779761253174 203.0491885412 220.510333965148 1.0859946574985 0.119017005886859 0.603434389591689 1 0.528987 0.544074 0.624841 0.553494 GeneID:7579,Genbank:XM_017002239.1,HGNC:HGNC:13093,MIM:611315 zinc finger and SCAN domain containing 20 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZSCAN21 333.782920412942 340.939514933141 326.626325892743 0.958018392079885 -0.0618747417362017 0.744508796856286 1 3.13314 3.24698 2.96424 3.10795 GeneID:7589,Genbank:XM_017012585.2,HGNC:HGNC:13104,MIM:601261 zinc finger and SCAN domain containing 21 GO:0000978,GO:0001077,GO:0005634,GO:0006355,GO:0045944,GO:0046872 RNA polymerase II proximal promoter sequence-specific DNA binding|transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding|nucleus|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|metal ion binding ZSCAN22 158.203888398913 152.120997358066 164.28677943976 1.07997437758745 0.110997084827618 0.656039400191058 1 1.04226 0.937529 1.08222 1.11931 GeneID:342945,Genbank:XM_017026746.1,HGNC:HGNC:4929,MIM:165260 zinc finger and SCAN domain containing 22 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZSCAN25 710.68366736445 743.377069483522 677.990265245379 0.912040864693914 -0.132829627985867 0.403352795572999 1 3.07272 3.44269 2.88153 2.9066 GeneID:221785,Genbank:XM_011515907.2,HGNC:HGNC:21961 zinc finger and SCAN domain containing 25 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZSCAN26 254.510315294165 271.042617897724 237.978012690607 0.878009571101492 -0.187691428355206 0.385115683559317 1 2.70113 2.4801 2.59039 1.96072 GeneID:7741,Genbank:NM_001023560.3,HGNC:HGNC:12978,MIM:616474 zinc finger and SCAN domain containing 26 GO:0003676,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006351,GO:0006355,GO:0046872 nucleic acid binding|DNA binding transcription factor activity|nucleus|nucleoplasm|cytosol|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZSCAN29 480.279725474076 399.323621349258 561.235829598895 1.4054661422296 0.491048699519889 0.00509578458818086 0.283382242931613 2.04211 1.91879 3.06415 2.46962 GeneID:146050,Genbank:XM_011521266.2,HGNC:HGNC:26673 zinc finger and SCAN domain containing 29 GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZSCAN30 77.7362737820305 56.1170628508172 99.3554847132437 1.77050400833295 0.824160109922288 0.0142253926076909 0.494072291254673 0.350814 0.486909 0.797082 0.711064 GeneID:100101467,Genbank:NM_001288711.1,HGNC:HGNC:33517 zinc finger and SCAN domain containing 30 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZSCAN31 305.007255052499 244.598379502243 365.416130602756 1.4939433832161 0.579125474565506 0.0033444946409566 0.216864073560976 1.36395 1.16633 1.92125 1.91854 GeneID:64288,Genbank:XM_011514808.3,HGNC:HGNC:14097,MIM:610794 zinc finger and SCAN domain containing 31 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZSCAN32 291.617478252621 298.774774055446 284.460182449795 0.952089022070536 -0.0708316204138023 0.727487081530528 1 2.07638 2.22226 2.0496 2.12741 GeneID:54925,Genbank:NM_017810.3,HGNC:HGNC:20812 zinc finger and SCAN domain containing 32 GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZSCAN5A 87.3700970957896 67.6288364692612 107.111357722318 1.58381192571607 0.663401028633269 0.0394505944032671 0.756156754175857 0.328583 0.525066 0.816292 0.65031 GeneID:79149,Genbank:NM_001322072.1,HGNC:HGNC:23710 zinc finger and SCAN domain containing 5A GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZSCAN5B 0.780631827935889 1.07619535328461 0.48506830258717 0.450725141217823 -1.14968016979823 0.981241458110389 1 0.0341863 0 0.0160435 0 GeneID:342933,Genbank:XM_005258864.3,HGNC:HGNC:34246 zinc finger and SCAN domain containing 5B GO:0000981,GO:0003677,GO:0005634,GO:0006351,GO:0046872 RNA polymerase II transcription factor activity, sequence-specific DNA binding|DNA binding|nucleus|transcription, DNA-templated|metal ion binding ZSCAN9 289.887759088625 285.610489787498 294.165028389752 1.02995176615753 0.0425767758990596 0.85382713803027 1 2.44605 2.60743 2.41166 2.53673 GeneID:7746,Genbank:XM_017011267.1,HGNC:HGNC:12984,MIM:602246 zinc finger and SCAN domain containing 9 GO:0003677,GO:0003700,GO:0005634,GO:0006351,GO:0046872 DNA binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|metal ion binding ZSWIM1 310.174923387453 323.758606900164 296.591239874742 0.91608758363048 -0.126442559415652 0.513097169366641 1 3.55763 3.96974 3.57193 3.48817 GeneID:90204,Genbank:XM_005260611.4,HGNC:HGNC:16155 zinc finger SWIM-type containing 1 GO:0005634,GO:0008270 nucleus|zinc ion binding ZSWIM3 58.290856508849 60.3738179892707 56.2078950284273 0.930997854706096 -0.103150251494745 0.797573059944166 1 0.752208 0.865124 0.65227 0.893963 GeneID:140831,Genbank:NM_080752.3,HGNC:HGNC:16157 zinc finger SWIM-type containing 3 GO:0008270 zinc ion binding ZSWIM4 861.798043634844 839.170298582669 884.425788687018 1.05392885112925 0.0757774764745073 0.651235516786303 1 6.73053 7.45124 7.69655 7.69626 GeneID:65249,Genbank:XM_017027157.1,HGNC:HGNC:25704 zinc finger SWIM-type containing 4 GO:0008270 zinc ion binding ZSWIM5 113.357803437663 114.780535260791 111.935071614534 0.975209527993649 -0.0362158734390438 0.891729901191552 1 0.618312 0.832543 0.658025 0.831057 GeneID:57643,Genbank:XM_017001913.1,HGNC:HGNC:29299 zinc finger SWIM-type containing 5 GO:0005615,GO:0008270 extracellular space|zinc ion binding ZSWIM6 598.401727899087 586.15242735118 610.651028446995 1.04179561484804 0.0590722695862626 0.71318727803271 1 3.41868 3.09818 3.58141 3.1133 GeneID:57688,Genbank:NM_020928.1,HGNC:HGNC:29316,MIM:615951 zinc finger SWIM-type containing 6 GO:0008270 zinc ion binding ZSWIM7 331.536610668248 338.36367940866 324.709541927836 0.959646562820553 -0.0594249348377572 0.780704900847012 1 5.1453 4.01018 4.81196 4.05345 GeneID:125150,Genbank:NM_001042698.1,HGNC:HGNC:26993,MIM:614535 zinc finger SWIM-type containing 7 GO:0000724,GO:0005634,GO:0008270,GO:0050821,GO:0097196 double-strand break repair via homologous recombination|nucleus|zinc ion binding|protein stabilization|Shu complex ZSWIM8 2360.76119560223 2369.67302849115 2351.8493627133 0.99247842822045 -0.0108923496469749 0.932955563566213 1 15.0005 14.4908 14.8025 14.9166 GeneID:23053,Genbank:XM_005269648.2,HGNC:HGNC:23528 zinc finger SWIM-type containing 8 GO:0008270 zinc ion binding ZSWIM9 518.030374775247 445.284471928772 590.776277621722 1.32673900588256 0.407884593803667 0.0193979823295072 0.567967248609484 3.22728 3.59427 4.7654 4.33769 GeneID:374920,Genbank:XM_006723205.2,HGNC:HGNC:34495 zinc finger SWIM-type containing 9 GO:0005634,GO:0006511,GO:0007275 nucleus|ubiquitin-dependent protein catabolic process|multicellular organism development ZUP1 155.31859133193 156.031759918617 154.605422745244 0.990858674066636 -0.0132487940476756 0.990362577834628 1 2.30263 2.10429 2.21641 1.89296 GeneID:221302,Genbank:NM_145062.2,HGNC:HGNC:21224 zinc finger containing ubiquitin peptidase 1 GO:0003676,GO:0046872 nucleic acid binding|metal ion binding ZW10 404.64709207073 329.9844393007 479.30974484076 1.45252226394829 0.538560277118013 0.00313871692848463 0.210333432328912 3.65299 3.24265 5.61841 4.97022 GeneID:9183,Genbank:NM_004724.3,HGNC:HGNC:13194,MIM:603954 zw10 kinetochore protein GO:0000070,GO:0000132,GO:0000776,GO:0000777,GO:0000922,GO:0005634,GO:0005783,GO:0005789,GO:0005828,GO:0005829,GO:0006461,GO:0006888,GO:0006890,GO:0007030,GO:0007062,GO:0007080,GO:0007093,GO:0007094,GO:0007096,GO:0015031,GO:0016020,GO:0019237,GO:0034501,GO:0051301,GO:0051321,GO:0070939,GO:1990423 mitotic sister chromatid segregation|establishment of mitotic spindle orientation|kinetochore|condensed chromosome kinetochore|spindle pole|nucleus|endoplasmic reticulum|endoplasmic reticulum membrane|kinetochore microtubule|cytosol|protein complex assembly|ER to Golgi vesicle-mediated transport|retrograde vesicle-mediated transport, Golgi to ER|Golgi organization|sister chromatid cohesion|mitotic metaphase plate congression|mitotic cell cycle checkpoint|mitotic spindle assembly checkpoint|regulation of exit from mitosis|protein transport|membrane|centromeric DNA binding|protein localization to kinetochore|cell division|meiotic cell cycle|Dsl1/NZR complex|RZZ complex ZWILCH 1091.42353764228 1164.0686764176 1018.77839886697 0.875187537905618 -0.192335899638255 0.362504619989248 1 14.3695 12.328 13.1752 10.3278 GeneID:55055,Genbank:NM_001287821.1,HGNC:HGNC:25468,MIM:609984 zwilch kinetochore protein GO:0000776,GO:0000777,GO:0005829,GO:0007062,GO:0007093,GO:0051301,GO:1990423 kinetochore|condensed chromosome kinetochore|cytosol|sister chromatid cohesion|mitotic cell cycle checkpoint|cell division|RZZ complex ZWINT 2838.98716528459 2872.55255213001 2805.42177843917 0.976630271344883 -0.034115598867433 0.80892754472792 1 36.164 34.0568 35.0789 35.7367 GeneID:11130,Genbank:NM_001005413.1,HGNC:HGNC:13195,MIM:609177 ZW10 interacting kinetochore protein GO:0000070,GO:0000776,GO:0000777,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0007062,GO:0007093,GO:0016604,GO:0030425,GO:0047485,GO:0051301,GO:0051649 mitotic sister chromatid segregation|kinetochore|condensed chromosome kinetochore|nucleus|nucleoplasm|cytoplasm|cytosol|sister chromatid cohesion|mitotic cell cycle checkpoint|nuclear body|dendrite|protein N-terminus binding|cell division|establishment of localization in cell ZXDA 44.6621602515223 42.7890824485985 46.535238054446 1.08754933248096 0.121080844741959 0.787737976724426 1 0.475463 0.372869 0.60388 0.310076 GeneID:7789,Genbank:NM_007156.4,HGNC:HGNC:13198,MIM:300235 zinc finger, X-linked, duplicated A GO:0003676,GO:0003700,GO:0005634,GO:0006351,GO:0045893,GO:0046872,GO:0070742 nucleic acid binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|positive regulation of transcription, DNA-templated|metal ion binding|C2H2 zinc finger domain binding ZXDB 142.869596896457 151.976918534011 133.762275258904 0.880148620916861 -0.184180938687657 0.484877857044801 1 1.4766 1.422 1.37212 1.20855 GeneID:158586,Genbank:NM_007157.3,HGNC:HGNC:13199,MIM:300236 zinc finger, X-linked, duplicated B GO:0003676,GO:0005634,GO:0006351,GO:0006355,GO:0046872 nucleic acid binding|nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|metal ion binding ZXDC 515.893894252613 518.082562755501 513.705225749726 0.991550889143048 -0.0122412774203462 0.942913420277013 1 3.99942 4.1478 4.12662 3.92556 GeneID:79364,Genbank:XM_011513119.2,HGNC:HGNC:28160,MIM:615746 ZXD family zinc finger C GO:0003676,GO:0003700,GO:0005634,GO:0006351,GO:0030275,GO:0045893,GO:0046872,GO:0070742 nucleic acid binding|DNA binding transcription factor activity|nucleus|transcription, DNA-templated|LRR domain binding|positive regulation of transcription, DNA-templated|metal ion binding|C2H2 zinc finger domain binding ZYG11B 558.21817956074 573.602675999028 542.833683122451 0.946358351932394 -0.0795415110477021 0.679608695859215 1 3.23819 2.8312 3.2001 2.54478 GeneID:79699,Genbank:XM_017002336.2,HGNC:HGNC:25820 zyg-11 family member B, cell cycle regulator GO:0004842,GO:0031462,GO:0051438 ubiquitin-protein transferase activity|Cul2-RING ubiquitin ligase complex|regulation of ubiquitin-protein transferase activity ZYX 4989.92884007101 5465.14245892858 4514.71522121345 0.826092870431514 -0.275624114478239 0.0353515961012493 0.735313198905985 90.8476 95.1527 79.3718 78.9724 GeneID:7791,Genbank:XM_017012587.2,HGNC:HGNC:13200,MIM:602002 zyxin GO:0001725,GO:0003723,GO:0005634,GO:0005829,GO:0005886,GO:0005887,GO:0005913,GO:0005925,GO:0007155,GO:0007160,GO:0007165,GO:0007179,GO:0007229,GO:0007267,GO:0016032,GO:0043149,GO:0045335,GO:0046872,GO:0050727,GO:0071346 stress fiber|RNA binding|nucleus|cytosol|plasma membrane|integral component of plasma membrane|cell-cell adherens junction|focal adhesion|cell adhesion|cell-matrix adhesion|signal transduction|transforming growth factor beta receptor signaling pathway|integrin-mediated signaling pathway|cell-cell signaling|viral process|stress fiber assembly|phagocytic vesicle|metal ion binding|regulation of inflammatory response|cellular response to interferon-gamma hsa04510 Focal adhesion ZZEF1 1896.78321370742 1779.78232636795 2013.7841010469 1.13147774939225 0.178208214161063 0.212418584197372 1 4.67231 4.80669 5.90324 4.8435 GeneID:23140,Genbank:XM_005256561.2,HGNC:HGNC:29027 zinc finger ZZ-type and EF-hand domain containing 1 GO:0005509,GO:0008270 calcium ion binding|zinc ion binding ZZZ3 328.3556735197 391.107060374714 265.604286664687 0.679108902841629 -0.558285149295989 0.0624549741122929 0.89203234548829 1.9888 1.49777 1.391 1.05248 GeneID:26009,Genbank:XM_005270729.4,HGNC:HGNC:24523 zinc finger ZZ-type containing 3 GO:0003677,GO:0005634,GO:0005671,GO:0005730,GO:0006351,GO:0006355,GO:0008270 DNA binding|nucleus|Ada2/Gcn5/Ada3 transcription activator complex|nucleolus|transcription, DNA-templated|regulation of transcription, DNA-templated|zinc ion binding